{"text_format":"3","workbook":"xlsx","n_sheets":6,"sheets":["CTX_Con_down","CTX_Con_up","2D_CTX_down","2D_CTX_up","3D_CTX_down","3D_CTX_up"],"read":"whole","date_system":"1900"}

{"sheet":"CTX_Con_down","index":0,"n_rows":3438,"n_cols":38,"rows_kept":2250,"cut":true,"bounds":{"rows_first":1000,"rows_last":250,"rows_between":1000,"halvings":1}}
["Gene","CTX_count","CTX_normalize","Con_count","Con_normalize","FoldChange","Log2FoldChange","pval","padj","Up/Down","Significant","GeneName","Biotype","Position","NR:Seq-id","NR:Score","NR:Evalue","NR:Description","NT:Seq-id","NT:Score","NT:Evalue","NT:Description","Uniprot:UniProtKB-AC","Uniprot:Score","Uniprot:Evalue","Uniprot:Description","COG:gene","COG:Score","COG:Eval","COG:num","Pfam:pfam_ID","Pfam:pfam_Name","Pfam:pfam_Description","GO:biological_process","GO:cellular_component","GO:molecular_function","KEGG:KO","KEGG:Description"]
["ENSRNOG00000003897",10315,663.5684699,155382,10031.75088,0.066146825,-3.91818428,0,0,"down","yes","Col1a1","protein_coding","chr10:79883622-79900624:+","gi|455975|gb|AAB29425.1|",1373,{"v":8e-171,"d":"8.00E-171"},"type I collagen alpha 1 chain [Mus sp.]","gi|158711703|ref|NM_053304.1|",5825,0,"Rattus norvegicus collagen, type I, alpha 1 (Col1a1), mRNA","P02454",555,{"v":2e-166,"d":"2.00E-166"},"Collagen alpha-1(I) chain",".",".",".",".","pfam01410","COLFI","Fibrillar collagen C-terminal domain. Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1 alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.","GO:0001501|skeletal system development;GO:0001503|ossification;GO:0001568|blood vessel development;GO:0001649|osteoblast differentiation;GO:0001957|intramembranous ossification;GO:0001958|endochondral ossification;GO:0007584|response to nutrient;GO:0007601|visual perception;GO:0007605|sensory perception of sound;GO:0009410|response to xenobiotic stimulus;GO:0009612|response to mechanical stimulus;GO:0010718|positive regulation of epithelial to mesenchymal transition;GO:0010812|negative regulation of cell-substrate adhesion;GO:0015031|protein transport;GO:0030198|extracellular matrix organization;GO:0030199|collagen fibril organization;GO:0030335|positive regulation of cell migration;GO:0031667|response to nutrient levels;GO:0031960|response to corticosteroid;GO:0032355|response to estradiol;GO:0032964|collagen biosynthetic process;GO:0034504|protein localization to nucleus;GO:0034505|tooth mineralization;GO:0038063|collagen-activated tyrosine kinase receptor signaling pathway;GO:0042060|wound healing;GO:0042542|response to hydrogen peroxide;GO:0043434|response to peptide hormone;GO:0043588|skin development;GO:0043589|skin morphogenesis;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0044691|tooth eruption;GO:0045893|positive regulation of transcription, DNA-templated;GO:0048545|response to steroid hormone;GO:0048705|skeletal system morphogenesis;GO:0048706|embryonic skeletal system development;GO:0051591|response to cAMP;GO:0055093|response to hyperoxia;GO:0060325|face morphogenesis;GO:0060346|bone trabecula formation;GO:0060351|cartilage development involved in endochondral bone morphogenesis;GO:0071230|cellular response to amino acid stimulus;GO:0071260|cellular response to mechanical stimulus;GO:0071300|cellular response to retinoic acid;GO:0071306|cellular response to vitamin E;GO:0071356|cellular response to tumor necrosis factor;GO:0071364|cellular response to epidermal growth factor stimulus;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:1902617|response to fluoride;GO:1902618|cellular response to fluoride;","GO:0005576|extracellular region;GO:0005581|collagen trimer;GO:0005584|collagen type I trimer;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0030141|secretory granule;GO:0031012|extracellular matrix;","GO:0002020|protease binding;GO:0005201|extracellular matrix structural constituent;GO:0005515|protein binding;GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0048407|platelet-derived growth factor binding;","K06236","COL1A; collagen type I alpha"]
["ENSRNOG00000003357",14347,922.9487966,156986,10135.3081,0.091062727,-3.456995523,0,0,"down","yes","Col3a1","protein_coding","chr9:47374593-47410547:+","gi|528758139|gb|EPY77798.1|",1036,{"v":3e-165,"d":"3.00E-165"},"hypothetical protein CB1_001183009 [Camelus ferus]","gi|56711253|ref|NM_032085.1|",4769,0,"Rattus norvegicus collagen, type III, alpha 1 (Col3a1), mRNA","P13941",528,{"v":1e-158,"d":"1.00E-158"},"Collagen alpha-1(III) chain",".",".",".",".","pfam01410","COLFI","Fibrillar collagen C-terminal domain. Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1 alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.","GO:0001501|skeletal system development;GO:0001568|blood vessel development;GO:0001701|in utero embryonic development;GO:0001894|tissue homeostasis;GO:0002062|chondrocyte differentiation;GO:0007160|cell-matrix adhesion;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0007229|integrin-mediated signaling pathway;GO:0007507|heart development;GO:0009314|response to radiation;GO:0009612|response to mechanical stimulus;GO:0010467|gene expression;GO:0018149|peptide cross-linking;GO:0021987|cerebral cortex development;GO:0030198|extracellular matrix organization;GO:0030199|collagen fibril organization;GO:0030324|lung development;GO:0032905|transforming growth factor beta1 production;GO:0034097|response to cytokine;GO:0035025|positive regulation of Rho protein signal transduction;GO:0035264|multicellular organism growth;GO:0035904|aorta development;GO:0036022|limb joint morphogenesis;GO:0042060|wound healing;GO:0043588|skin development;GO:0048144|fibroblast proliferation;GO:0048251|elastic fiber assembly;GO:0048565|digestive tract development;GO:0050777|negative regulation of immune response;GO:0051216|cartilage development;GO:0060350|endochondral bone morphogenesis;GO:0060414|aorta smooth muscle tissue morphogenesis;GO:0071230|cellular response to amino acid stimulus;GO:0097435|supramolecular fiber organization;GO:2001223|negative regulation of neuron migration;","GO:0005581|collagen trimer;GO:0005586|collagen type III trimer;GO:0005615|extracellular space;GO:0031012|extracellular matrix;GO:0062023|collagen-containing extracellular matrix;","GO:0002020|protease binding;GO:0003674|molecular_function;GO:0005178|integrin binding;GO:0005201|extracellular matrix structural constituent;GO:0046332|SMAD binding;GO:0046872|metal ion binding;GO:0048407|platelet-derived growth factor binding;","K19720","COL3A; collagen type III alpha"]
["ENSRNOG00000011292",8391,539.7967068,81164,5240.098777,0.103012697,-3.279105927,0,0,"down","yes","Col1a2","protein_coding","chr4:32563381-32598867:+","gi|672048983|ref|XP_008760958.1|",1936,0,"PREDICTED: collagen alpha-2(I) chain isoform X2 [Rattus norvegicus]","gi|672048982|ref|XM_008762736.1|",4599,0,"PREDICTED: Rattus norvegicus collagen, type I, alpha 2 (Col1a2), transcript variant X2, mRNA","P02466",746,0,"Collagen alpha-2(I) chain",".",".",".",".","pfam01410","COLFI","Fibrillar collagen C-terminal domain. Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1 alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.","GO:0001501|skeletal system development;GO:0001568|blood vessel development;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0007266|Rho protein signal transduction;GO:0008217|regulation of blood pressure;GO:0030198|extracellular matrix organization;GO:0030199|collagen fibril organization;GO:0030282|bone mineralization;GO:0032963|collagen metabolic process;GO:0043589|skin morphogenesis;GO:0070208|protein heterotrimerization;GO:0071230|cellular response to amino acid stimulus;GO:0071300|cellular response to retinoic acid;GO:0071310|cellular response to organic substance;GO:0071873|response to norepinephrine;GO:0085029|extracellular matrix assembly;GO:0097067|cellular response to thyroid hormone stimulus;","GO:0005576|extracellular region;GO:0005581|collagen trimer;GO:0005584|collagen type I trimer;GO:0005615|extracellular space;GO:0005783|endoplasmic reticulum;GO:0031012|extracellular matrix;","GO:0002020|protease binding;GO:0003674|molecular_function;GO:0005201|extracellular matrix structural constituent;GO:0030674|protein binding, bridging;GO:0042802|identical protein binding;GO:0046332|SMAD binding;GO:0046872|metal ion binding;GO:0048407|platelet-derived growth factor binding;","K06236","COL1A; collagen type I alpha"]
["ENSRNOG00000012840",26880,1729.202178,92086,5945.243408,0.290854732,-1.781629319,0,0,"down","yes","Sparc","protein_coding","chr10:39516406-39538396:-","gi|6981574|ref|NP_036788.1|",1294,{"v":9e-171,"d":"9.00E-171"},"SPARC precursor [Rattus norvegicus]","gi|672067231|ref|XM_008767663.1|",1065,0,"PREDICTED: Rattus norvegicus secreted protein, acidic, cysteine-rich (osteonectin) (Sparc), transcript variant X1, mRNA","P16975",503,{"v":3e-172,"d":"3.00E-172"},"SPARC",".",".",".",".","pfam10591","SPARC_Ca_bdg","Secreted protein acidic and rich in cysteine Ca binding region. The SPARC_Ca_bdg domain of Secreted Protein Acidic and Rich in Cysteine is responsible for the anti-spreading activity of human urothelial cells. It is rich in alpha-helices. This extracellular calcium-binding domain contains two EF-hands that each coordinates one Ca2+ ion, forming a helix-loop-helix structure that not only drives the conformation of the protein but is also necessary for biological activity. The anti-spreading activity was dependent on the coordination of Ca2+ by a Glu residue at the Z position of EF-hand 2.","GO:0001503|ossification;GO:0001937|negative regulation of endothelial cell proliferation;GO:0007507|heart development;GO:0009629|response to gravity;GO:0010288|response to lead ion;GO:0010595|positive regulation of endothelial cell migration;GO:0016525|negative regulation of angiogenesis;GO:0022604|regulation of cell morphogenesis;GO:0030324|lung development;GO:0032496|response to lipopolysaccharide;GO:0033591|response to L-ascorbic acid;GO:0034097|response to cytokine;GO:0042060|wound healing;GO:0042127|regulation of cell proliferation;GO:0043434|response to peptide hormone;GO:0043473|pigmentation;GO:0045471|response to ethanol;GO:0046686|response to cadmium ion;GO:0048839|inner ear development;GO:0048856|anatomical structure development;GO:0050807|regulation of synapse organization;GO:0051384|response to glucocorticoid;GO:0051591|response to cAMP;GO:0051592|response to calcium ion;GO:0060348|bone development;GO:0071363|cellular response to growth factor stimulus;","GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0009986|cell surface;GO:0016363|nuclear matrix;GO:0031012|extracellular matrix;GO:0031091|platelet alpha granule;GO:0031092|platelet alpha granule membrane;GO:0031982|vesicle;GO:0043231|intracellular membrane-bounded organelle;GO:0045202|synapse;GO:0098978|glutamatergic synapse;","GO:0005509|calcium ion binding;GO:0005518|collagen binding;GO:0050840|extracellular matrix binding;","K24262","SPARC; secreted protein acidic and rich in cysteine"]
["ENSRNOG00000001249",7695,495.0227218,43470,2806.504039,0.176384112,-2.503207483,0,0,"down","yes","Col6a1","protein_coding","chr20:11905957-11924597:+","gi|293344916|ref|XP_001079629.2|",4385,0,"PREDICTED: collagen alpha-1(VI) chain [Rattus norvegicus]","gi|564321937|ref|XM_001079629.4|",4037,0,"PREDICTED: Rattus norvegicus collagen, type VI, alpha 1 (Col6a1), mRNA","Q04857",1628,0,"Collagen alpha-1(VI) chain",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0008150|biological_process;GO:0008584|male gonad development;GO:0008585|female gonad development;GO:0030198|extracellular matrix organization;GO:0035987|endodermal cell differentiation;GO:0071230|cellular response to amino acid stimulus;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005594|collagen type IX trimer;GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0031012|extracellular matrix;GO:0032991|protein-containing complex;GO:0042383|sarcolemma;","GO:0003674|molecular_function;GO:0005201|extracellular matrix structural constituent;GO:0005518|collagen binding;GO:0048407|platelet-derived growth factor binding;","K06238","COL6A; collagen type VI alpha"]
["ENSRNOG00000057880",3907,251.339022,32335,2087.607732,0.120395713,-3.054144069,0,0,"down","yes","Myh11","protein_coding","chr10:743685-838459:+","gi|564370691|ref|XP_006245904.1|",8793,0,"PREDICTED: myosin-11 isoform X1 [Rattus norvegicus]","gi|282158050|ref|NM_001170600.1|",5881,0,"Rattus norvegicus myosin, heavy chain 11, smooth muscle (Myh11), mRNA","O08638",3311,0,"Myosin-11","SPCC645.05c",784,0,"COG5022","pfam00063","Myosin_head","Myosin head (motor domain).","GO:0006939|smooth muscle contraction;GO:0048251|elastic fiber assembly;GO:0055013|cardiac muscle cell development;","GO:0001725|stress fiber;GO:0005859|muscle myosin complex;GO:0005903|brush border;GO:0016459|myosin complex;GO:0030016|myofibril;GO:0030485|smooth muscle contractile fiber;GO:0032982|myosin filament;GO:0042470|melanosome;","GO:0003774|motor activity;GO:0003779|actin binding;GO:0005516|calmodulin binding;GO:0005524|ATP binding;GO:0008307|structural constituent of muscle;GO:0051015|actin filament binding;","K10352","MYH9s; myosin heavy chain 9/10/11/14"]
["ENSRNOG00000001254",4606,296.3059983,32487,2097.421135,0.14127158,-2.823456828,0,0,"down","yes","Col6a2","protein_coding","chr20:12021767-12057564:+","gi|564397478|ref|XP_006256362.1|",3773,0,"PREDICTED: collagen alpha-2(VI) chain isoform X1 [Rattus norvegicus]","gi|672086225|ref|XM_006256300.2|",3860,0,"PREDICTED: Rattus norvegicus collagen, type VI, alpha 2 (Col6a2), transcript variant X1, mRNA","Q02788",1216,0,"Collagen alpha-2(VI) chain",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0009749|response to glucose;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005581|collagen trimer;GO:0005615|extracellular space;GO:0031012|extracellular matrix;GO:0032991|protein-containing complex;GO:0042383|sarcolemma;GO:0062023|collagen-containing extracellular matrix;","GO:0003674|molecular_function;GO:0005518|collagen binding;","K06238","COL6A; collagen type VI alpha"]
["ENSRNOG00000030644",30768,1979.318922,77408,4997.604432,0.396053539,-1.336232626,0,0,"down","yes","Mt-nd1","protein_coding","chrMT:2740-3694:+","gi|19577314|emb|CAD21559.1|",989,{"v":2e-130,"d":"2.00E-130"},"NADH dehydrogenase subunit 1, partial (mitochondrion) [Rattus norvegicus]","gi|755572967|gb|KP244683.1|",955,0,"Rattus norvegicus isolate 115 mitochondrion, complete genome","P03889",385,{"v":8e-132,"d":"8.00E-132"},"NADH-ubiquinone oxidoreductase chain 1","RC1230",187,{"v":5e-55,"d":"5.00E-55"},"COG1005","pfam00146","NADHdh","NADH dehydrogenase.","GO:0006120|mitochondrial electron transport, NADH to ubiquinone;GO:0009060|aerobic respiration;GO:0009410|response to xenobiotic stimulus;GO:0014070|response to organic cyclic compound;GO:0032981|mitochondrial respiratory chain complex I assembly;GO:0033194|response to hydroperoxide;","GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0005747|mitochondrial respiratory chain complex I;GO:0030425|dendrite;GO:0031966|mitochondrial membrane;GO:0043025|neuronal cell body;","GO:0003674|molecular_function;GO:0003954|NADH dehydrogenase activity;GO:0008137|NADH dehydrogenase (ubiquinone) activity;","K03878","ND1; NADH-ubiquinone oxidoreductase chain 1 [EC:7.1.1.2]"]
["ENSRNOG00000012660",59,3.795495853,20404,1317.320184,0.002881225,-8.439101955,0,0,"down","yes","Postn","protein_coding","chr2:138527696-138559099:+","gi|564336409|ref|XP_006232397.1|",4144,0,"PREDICTED: periostin isoform X1 [Rattus norvegicus]","gi|672042357|ref|XM_006232335.2|",3278,0,"PREDICTED: Rattus norvegicus periostin, osteoblast specific factor (Postn), transcript variant X1, mRNA","Q62009",1575,0,"Periostin","all4647",79,{"v":1e-15,"d":"1.00E-15"},"COG2335","pfam02469","Fasciclin","Fasciclin domain. This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.","GO:0001666|response to hypoxia;GO:0001953|negative regulation of cell-matrix adhesion;GO:0003073|regulation of systemic arterial blood pressure;GO:0007155|cell adhesion;GO:0008593|regulation of Notch signaling pathway;GO:0009612|response to mechanical stimulus;GO:0009888|tissue development;GO:0014850|response to muscle activity;GO:0014911|positive regulation of smooth muscle cell migration;GO:0030198|extracellular matrix organization;GO:0032355|response to estradiol;GO:0042060|wound healing;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0071307|cellular response to vitamin K;GO:0071356|cellular response to tumor necrosis factor;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:1900025|negative regulation of substrate adhesion-dependent cell spreading;GO:1990138|neuron projection extension;GO:1990523|bone regeneration;GO:2000343|positive regulation of chemokine (C-X-C motif) ligand 2 production;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005802|trans-Golgi network;GO:0031012|extracellular matrix;GO:0031594|neuromuscular junction;GO:0062023|collagen-containing extracellular matrix;","GO:0003674|molecular_function;GO:0008201|heparin binding;GO:0046872|metal ion binding;GO:0050839|cell adhesion molecule binding;","K24790","POSTN; periostin"]
["ENSRNOG00000018735",4869,313.2249035,26533,1713.019822,0.18284955,-2.451271019,0,0,"down","yes","Cd74","protein_coding","chr18:54256778-54266003:+","gi|6978637|ref|NP_037201.1|",891,{"v":3e-111,"d":"3.00E-111"},"H-2 class II histocompatibility antigen gamma chain [Rattus norvegicus]","gi|672083268|ref|XM_006254761.2|",719,0,"PREDICTED: Rattus norvegicus Cd74 molecule, major histocompatibility complex, class II invariant chain (Cd74), transcript variant X1, mRNA","P10247",343,{"v":3e-110,"d":"3.00E-110"},"H-2 class II histocompatibility antigen gamma chain",".",".",".",".","pfam08831","MHCassoc_trimer","Class II MHC-associated invariant chain trimerization domain. The class II associated invariant chain peptide is required for folding and localisation of MHC class II heterodimers. This domain is involved in trimerization of the ectoderm and interferes with DM/class II binding. The trimeric protein forms a cylindrical shape which is thought to be important for interactions between the invariant chain and class II molecules.","GO:0001516|prostaglandin biosynthetic process;GO:0001934|positive regulation of protein phosphorylation;GO:0001961|positive regulation of cytokine-mediated signaling pathway;GO:0002286|T cell activation involved in immune response;GO:0002606|positive regulation of dendritic cell antigen processing and presentation;GO:0002792|negative regulation of peptide secretion;GO:0002830|positive regulation of type 2 immune response;GO:0002906|negative regulation of mature B cell apoptotic process;GO:0006886|intracellular protein transport;GO:0006952|defense response;GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0008283|cell proliferation;GO:0010628|positive regulation of gene expression;GO:0016064|immunoglobulin mediated immune response;GO:0019882|antigen processing and presentation;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0023019|signal transduction involved in regulation of gene expression;GO:0030336|negative regulation of cell migration;GO:0030890|positive regulation of B cell proliferation;GO:0031394|positive regulation of prostaglandin biosynthetic process;GO:0032722|positive regulation of chemokine production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0033674|positive regulation of kinase activity;GO:0034341|response to interferon-gamma;GO:0035691|macrophage migration inhibitory factor signaling pathway;GO:0043066|negative regulation of apoptotic process;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043410|positive regulation of MAPK cascade;GO:0043518|negative regulation of DNA damage response, signal transduction by p53 class mediator;GO:0045059|positive thymic T cell selection;GO:0045060|negative thymic T cell selection;GO:0045581|negative regulation of T cell differentiation;GO:0045582|positive regulation of T cell differentiation;GO:0045657|positive regulation of monocyte differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0046597|negative regulation of viral entry into host cell;GO:0046598|positive regulation of viral entry into host cell;GO:0048146|positive regulation of fibroblast proliferation;GO:0050729|positive regulation of inflammatory response;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050821|protein stabilization;GO:0051085|chaperone cofactor-dependent protein refolding;GO:0060907|positive regulation of macrophage cytokine production;GO:0065003|protein-containing complex assembly;GO:0070206|protein trimerization;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0090023|positive regulation of neutrophil chemotaxis;GO:1900017|positive regulation of cytokine production involved in inflammatory response;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1902166|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:2000343|positive regulation of chemokine (C-X-C motif) ligand 2 production;GO:2000448|positive regulation of macrophage migration inhibitory factor signaling pathway;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0005770|late endosome;GO:0005771|multivesicular body;GO:0005773|vacuole;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0032991|protein-containing complex;GO:0035692|macrophage migration inhibitory factor receptor complex;GO:0035693|NOS2-CD74 complex;GO:0042613|MHC class II protein complex;","GO:0001540|amyloid-beta binding;GO:0004896|cytokine receptor activity;GO:0019955|cytokine binding;GO:0023026|MHC class II protein complex binding;GO:0035718|macrophage migration inhibitory factor binding;GO:0042289|MHC class II protein binding;GO:0042609|CD4 receptor binding;GO:0042658|MHC class II protein binding, via antigen binding groove;GO:0044183|protein binding involved in protein folding;GO:0050998|nitric-oxide synthase binding;","K06505","CD74, DHLAG; CD74 antigen"]
["ENSRNOG00000016695",3172,204.0561499,21949,1417.068258,0.143998815,-2.795871155,0,0,"down","yes","Mmp2","protein_coding","chr19:14154657-14182870:-","gi|146262019|ref|NP_112316.2|",3285,0,"72 kDa type IV collagenase precursor [Rattus norvegicus]","gi|146262018|ref|NM_031054.2|",3040,0,"Rattus norvegicus matrix metallopeptidase 2 (Mmp2), mRNA","P33436",1270,0,"72 kDa type IV collagenase",".",".",".",".","pfam00413","Peptidase_M10","Matrixin. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.","GO:0001525|angiogenesis;GO:0001541|ovarian follicle development;GO:0001542|ovulation from ovarian follicle;GO:0001553|luteinization;GO:0001666|response to hypoxia;GO:0001955|blood vessel maturation;GO:0001957|intramembranous ossification;GO:0006508|proteolysis;GO:0006979|response to oxidative stress;GO:0007162|negative regulation of cell adhesion;GO:0007507|heart development;GO:0007565|female pregnancy;GO:0007566|embryo implantation;GO:0007567|parturition;GO:0007568|aging;GO:0009314|response to radiation;GO:0009410|response to xenobiotic stimulus;GO:0009612|response to mechanical stimulus;GO:0014012|peripheral nervous system axon regeneration;GO:0014823|response to activity;GO:0016477|cell migration;GO:0030198|extracellular matrix organization;GO:0030335|positive regulation of cell migration;GO:0030574|collagen catabolic process;GO:0032526|response to retinoic acid;GO:0034097|response to cytokine;GO:0034614|cellular response to reactive oxygen species;GO:0035094|response to nicotine;GO:0035987|endodermal cell differentiation;GO:0042542|response to hydrogen peroxide;GO:0043065|positive regulation of apoptotic process;GO:0043627|response to estrogen;GO:0045089|positive regulation of innate immune response;GO:0045906|negative regulation of vasoconstriction;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0048705|skeletal system morphogenesis;GO:0048771|tissue remodeling;GO:0051602|response to electrical stimulus;GO:0055093|response to hyperoxia;GO:0060325|face morphogenesis;GO:0060346|bone trabecula formation;GO:0060740|prostate gland epithelium morphogenesis;GO:0071230|cellular response to amino acid stimulus;GO:0071345|cellular response to cytokine stimulus;GO:0071347|cellular response to interleukin-1;GO:0071392|cellular response to estradiol stimulus;GO:0071492|cellular response to UV-A;GO:0071498|cellular response to fluid shear stress;GO:1904645|response to amyloid-beta;GO:1904707|positive regulation of vascular smooth muscle cell proliferation;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005886|plasma membrane;GO:0030017|sarcomere;GO:0031012|extracellular matrix;","GO:0001968|fibronectin binding;GO:0004175|endopeptidase activity;GO:0004222|metalloendopeptidase activity;GO:0004252|serine-type endopeptidase activity;GO:0005515|protein binding;GO:0008233|peptidase activity;GO:0008237|metallopeptidase activity;GO:0008270|zinc ion binding;","K01398","MMP2; matrix metalloproteinase-2 (gelatinase A) [EC:3.4.24.24]"]
["ENSRNOG00000029971",10767,692.6458279,37172,2399.893447,0.288615242,-1.792780603,0,0,"down","yes","Mt-nd5","protein_coding","chrMT:11736-13565:+","gi|110189725|ref|YP_665639.1|",2147,0,"NADH dehydrogenase subunit 5 [Rattus norvegicus]","gi|755572967|gb|KP244683.1|",1830,0,"Rattus norvegicus isolate 115 mitochondrion, complete genome","P11661",831,0,"NADH-ubiquinone oxidoreductase chain 5","AGc2360",257,{"v":4e-75,"d":"4.00E-75"},"COG1009","pfam00361","Oxidored_q1","NADH-Ubiquinone/plastoquinone (complex I), various chains. This family is part of complex I which catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane.","GO:0001666|response to hypoxia;GO:0006120|mitochondrial electron transport, NADH to ubiquinone;GO:0010243|response to organonitrogen compound;GO:0015990|electron transport coupled proton transport;GO:0032981|mitochondrial respiratory chain complex I assembly;GO:0042542|response to hydrogen peroxide;","GO:0005743|mitochondrial inner membrane;GO:0005747|mitochondrial respiratory chain complex I;GO:0043005|neuron projection;","GO:0003674|molecular_function;GO:0003954|NADH dehydrogenase activity;GO:0008137|NADH dehydrogenase (ubiquinone) activity;","K03883","ND5; NADH-ubiquinone oxidoreductase chain 5 [EC:7.1.1.2]"]
["ENSRNOG00000029707",40826,2626.354469,83362,5382.005745,0.487988046,-1.035082286,0,0,"down","yes","Mt-nd4","protein_coding","chrMT:10160-11537:+","gi|829028|gb|AAD15023.1|",1149,{"v":3e-150,"d":"3.00E-150"},"unknown protein [Rattus norvegicus]","gi|755572967|gb|KP244683.1|",1378,0,"Rattus norvegicus isolate 115 mitochondrion, complete genome","P05508",446,{"v":2e-151,"d":"2.00E-151"},"NADH-ubiquinone oxidoreductase chain 4","BMEI1146",96.7,{"v":1e-20,"d":"1.00E-20"},"COG1008","pfam00361","Oxidored_q1","NADH-Ubiquinone/plastoquinone (complex I), various chains. This family is part of complex I which catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane.","GO:0001666|response to hypoxia;GO:0001701|in utero embryonic development;GO:0006120|mitochondrial electron transport, NADH to ubiquinone;GO:0007568|aging;GO:0009060|aerobic respiration;GO:0015990|electron transport coupled proton transport;GO:0021549|cerebellum development;GO:0032981|mitochondrial respiratory chain complex I assembly;GO:0035094|response to nicotine;GO:0045471|response to ethanol;","GO:0005575|cellular_component;GO:0005743|mitochondrial inner membrane;GO:0005747|mitochondrial respiratory chain complex I;GO:0045271|respiratory chain complex I;","GO:0003674|molecular_function;GO:0003954|NADH dehydrogenase activity;GO:0008137|NADH dehydrogenase (ubiquinone) activity;GO:0048039|ubiquinone binding;","K03881","ND4; NADH-ubiquinone oxidoreductase chain 4 [EC:7.1.1.2]"]
["ENSRNOG00000055962",5323,342.4309225,24841,1603.781156,0.213514744,-2.2275924,0,0,"down","yes","Bgn","protein_coding","chrX:151197273-151209461:+","gi|532058378|ref|XP_005371884.1|",1829,0,"PREDICTED: biglycan [Microtus ochrogaster]","gi|47939034|gb|BC072480.1|",2354,0,"Rattus norvegicus biglycan, mRNA (cDNA clone MGC:91754 IMAGE:7104041), complete cds","P47853",701,0,"Biglycan","lin0290_1",62,3E-9,"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0001974|blood vessel remodeling;GO:0019800|peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan;GO:0060348|bone development;GO:0061975|articular cartilage development;","GO:0005615|extracellular space;GO:0009986|cell surface;GO:0030133|transport vesicle;GO:0031012|extracellular matrix;GO:0042383|sarcolemma;","GO:0005539|glycosaminoglycan binding;GO:0050840|extracellular matrix binding;","K08118","BGN; biglycan"]
["ENSRNOG00000046834",99,6.36871338,12850,829.6198966,0.007676664,-7.025304738,0,0,"down","yes","C3","protein_coding","chr9:2087437-2114429:-","gi|158138561|ref|NP_058690.2|",7781,0,"complement C3 precursor [Rattus norvegicus]","gi|158138560|ref|NM_016994.2|",4433,0,"Rattus norvegicus complement component 3 (C3), mRNA","P01026",2956,0,"Complement C3",".",".",".",".","pfam07678","A2M_comp","A-macroglobulin complement component. This family includes the complement components region of the alpha-2-macroglobulin family.","GO:0001798|positive regulation of type IIa hypersensitivity;GO:0001934|positive regulation of protein phosphorylation;GO:0001970|positive regulation of activation of membrane attack complex;GO:0002507|tolerance induction;GO:0006631|fatty acid metabolic process;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0006956|complement activation;GO:0006957|complement activation, alternative pathway;GO:0006958|complement activation, classical pathway;GO:0007596|blood coagulation;GO:0009617|response to bacterium;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0010828|positive regulation of glucose transmembrane transport;GO:0010866|regulation of triglyceride biosynthetic process;GO:0010884|positive regulation of lipid storage;GO:0010951|negative regulation of endopeptidase activity;GO:0016322|neuron remodeling;GO:0032026|response to magnesium ion;GO:0032355|response to estradiol;GO:0032570|response to progesterone;GO:0035846|oviduct epithelium development;GO:0035886|vascular smooth muscle cell differentiation;GO:0043627|response to estrogen;GO:0045087|innate immune response;GO:0045745|positive regulation of G protein-coupled receptor signaling pathway;GO:0045766|positive regulation of angiogenesis;GO:0048260|positive regulation of receptor-mediated endocytosis;GO:0048639|positive regulation of developmental growth;GO:0050766|positive regulation of phagocytosis;GO:0051384|response to glucocorticoid;GO:0060041|retina development in camera-type eye;GO:0060100|positive regulation of phagocytosis, engulfment;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0097242|amyloid-beta clearance;GO:0097278|complement-dependent cytotoxicity;GO:0150062|complement-mediated synapse pruning;GO:0150064|vertebrate eye-specific patterning;GO:1901555|response to paclitaxel;GO:1905114|cell surface receptor signaling pathway involved in cell-cell signaling;GO:2000427|positive regulation of apoptotic cell clearance;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0009986|cell surface;GO:0032991|protein-containing complex;","GO:0004866|endopeptidase inhibitor activity;GO:0005515|protein binding;GO:0008289|lipid binding;GO:0031715|C5L2 anaphylatoxin chemotactic receptor binding;","K03990","C3; complement component 3"]
["ENSRNOG00000051235",1148,73.85134304,14609,943.1842077,0.078300021,-3.6748435,0,0,"down","yes","Cfb","protein_coding","chr20:3951474-3976505:+","gi|47575877|ref|NP_757376.2|",3941,0,"complement C2 precursor [Rattus norvegicus]","gi|47575876|ref|NM_172222.2|",1879,0,"Rattus norvegicus complement component 2 (C2), mRNA","P21180",1314,0,"Complement C2",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0006508|proteolysis;GO:0006956|complement activation;GO:0006958|complement activation, classical pathway;GO:0007584|response to nutrient;GO:0045087|innate immune response;GO:2000427|positive regulation of apoptotic cell clearance;","GO:0005575|cellular_component;GO:0005576|extracellular region;","GO:0004252|serine-type endopeptidase activity;GO:0005515|protein binding;","K01332","C2; complement component 2 [EC:3.4.21.43]"]
["ENSRNOG00000004554",5516,354.846697,24511,1582.475742,0.224235157,-2.156915602,0,0,"down","yes","Dcn","protein_coding","chr7:32281252-32321270:+","gi|54020664|ref|NP_077043.1|",1798,0,"decorin precursor [Rattus norvegicus]","gi|564359075|ref|XM_006241285.1|",1577,0,"PREDICTED: Rattus norvegicus decorin (Dcn), transcript variant X1, mRNA","Q01129",697,0,"Decorin","SPy1798",59.7,2E-8,"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0001822|kidney development;GO:0001890|placenta development;GO:0007519|skeletal muscle tissue development;GO:0007568|aging;GO:0009612|response to mechanical stimulus;GO:0010508|positive regulation of autophagy;GO:0010596|negative regulation of endothelial cell migration;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0016239|positive regulation of macroautophagy;GO:0016525|negative regulation of angiogenesis;GO:0019800|peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan;GO:0032496|response to lipopolysaccharide;GO:0042060|wound healing;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051901|positive regulation of mitochondrial depolarization;GO:0090141|positive regulation of mitochondrial fission;GO:1900747|negative regulation of vascular endothelial growth factor signaling pathway;","GO:0005589|collagen type VI trimer;GO:0005615|extracellular space;GO:0031012|extracellular matrix;","GO:0005518|collagen binding;GO:0005539|glycosaminoglycan binding;GO:0030021|extracellular matrix structural constituent conferring compression resistance;GO:0047485|protein N-terminus binding;GO:0050840|extracellular matrix binding;","K04660","DCN; decorin"]
["ENSRNOG00000005825",2629,169.124722,18006,1162.500845,0.145483526,-2.781072297,0,0,"down","yes","Lyz2","protein_coding","chr7:52906811-52912106:-","gi|674274809|tpe|CDM98787.1|",488,{"v":8E-55,"d":"8.00E-55"},"TPA: lysozyme f2 [Rattus norvegicus]","gi|349088|gb|L12459.1|RATLYSOZYM",891,0,"Rat lysozyme gene exons 1-4, complete cds","P00697",189,{"v":4E-55,"d":"4.00E-55"},"Lysozyme C-1",".",".",".",".","pfam00062","Lys","C-type lysozyme/alpha-lactalbumin family. Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.","GO:0001895|retina homeostasis;GO:0019835|cytolysis;GO:0031640|killing of cells of other organism;GO:0042742|defense response to bacterium;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;","GO:0000137|Golgi cis cisterna;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005788|endoplasmic reticulum lumen;GO:0005795|Golgi stack;GO:0005902|microvillus;GO:0030140|trans-Golgi network transport vesicle;GO:0030141|secretory granule;GO:0048237|rough endoplasmic reticulum lumen;","GO:0003796|lysozyme activity;GO:0016798|hydrolase activity, acting on glycosyl bonds;GO:0042802|identical protein binding;","K13915","LYZ; lysozyme C [EC:3.2.1.17]"]
["ENSRNOG00000060381",332,21.35770548,10836,699.5923112,0.030528788,-5.033685866,0,0,"down","yes","Col15a1","protein_coding","chr5:61501963-61607591:+","gi|407228400|ref|NP_001094005.1|",4836,0,"collagen alpha-1(XV) chain precursor [Rattus norvegicus]","gi|672052583|ref|XM_003749933.3|",5190,0,"PREDICTED: Rattus norvegicus collagen alpha-1(XV) chain-like (LOC100909752), mRNA","O35206",1653,0,"Collagen alpha-1(XV) chain",".",".",".",".","pfam06482","Endostatin","Collagenase NC10 and Endostatin. NC10 stands for Non-helical region 10 and is taken from human COL15A1. A mutation in this region in human COL18A1 is associated with an increased risk of prostrate cancer. This domain is cleaved from the precursor and forms endostatin. Endostatin is a key tumor suppressor and has been used highly successfully to treat cancer. It is a potent angiogenesis inhibitor. Endostatin also binds a zinc ion near the N-terminus; this is likely to be of structural rather than functional importance.","GO:0001525|angiogenesis;GO:0001886|endothelial cell morphogenesis;GO:0030198|extracellular matrix organization;","GO:0005581|collagen trimer;GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0031012|extracellular matrix;","GO:0005201|extracellular matrix structural constituent;","K08135","COL15A; collagen type XV alpha"]
["ENSRNOG00000061379",2181,140.3046857,15003,968.6215804,0.144849845,-2.787369955,0,0,"down","yes","ENSRNOG00000061379","pseudogene","chr2:54088116-54158535:-","gi|293345196|ref|XP_001054007.2|",3003,0,"PREDICTED: complement component C7 isoform X1 [Rattus norvegicus]","gi|672041789|ref|XM_008760831.1|",2626,0,"PREDICTED: Rattus norvegicus complement component 7 (C7), transcript variant X3, mRNA","Q9TUQ3",916,0,"Complement component C7",".",".",".",".","pfam01823","MACPF","MAC/Perforin domain. The membrane-attack complex (MAC) of the complement system forms transmembrane channels. These channels disrupt the phospholipid bilayer of target cells, leading to cell lysis and death. A number of proteins participate in the assembly of the MAC. Freshly activated C5b binds to C6 to form a C5b-6 complex, then to C7 forming the C5b-7 complex. The C5b-7 complex binds to C8, which is composed of three chains (alpha, beta, and gamma), thus forming the C5b-8 complex. C5b-8 subsequently binds to C9 and acts as a catalyst in the polymerization of C9. Active MAC has a subunit composition of C5b-C6-C7-C8-C9{n}. Perforin is a protein found in cytolytic T-cell and killer cells. In the presence of calcium, perforin polymerizes into transmembrane tubules and is capable of lysing, non-specifically, a variety of target cells. There are a number of regions of similarity in the sequences of complement components C6, C7, C8-alpha, C8-beta, C9 and perforin. The X-ray crystal structure of a MACPF domain reveals that it shares a common fold with bacterial cholesterol dependent cytolysins (pfam01289) such as perfringolysin O. Three key pieces of evidence suggests that MACPF domains and CDCs are homologous: Functional similarity (pore formation), conservation of three glycine residues at a hinge in both families and conservation of a complex core fold.","GO:0006883|cellular sodium ion homeostasis;GO:0006958|complement activation, classical pathway;GO:0019835|cytolysis;GO:0045087|innate immune response;","GO:0005576|extracellular region;GO:0005579|membrane attack complex;","GO:0003674|molecular_function;","K03996","C7; complement component 7"]
["ENSRNOG00000017206",2009,129.2398503,13956,901.0253133,0.143436426,-2.801516653,0,0,"down","yes","Igfbp5","protein_coding","chr9:74448382-74465156:-","gi|148667878|gb|EDL00295.1|",1581,0,"insulin-like growth factor binding protein 5, isoform CRA_b, partial [Mus musculus]","gi|56541201|gb|BC087030.1|",5811,0,"Rattus norvegicus insulin-like growth factor binding protein 5, mRNA (cDNA clone IMAGE:7110383)","P24594",524,{"v":6e-170,"d":"6.00E-170"},"Insulin-like growth factor-binding protein 5",".",".",".",".","pfam00086","Thyroglobulin_1","Thyroglobulin type-1 repeat. Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.","GO:0001558|regulation of cell growth;GO:0001649|osteoblast differentiation;GO:0007565|female pregnancy;GO:0007568|aging;GO:0014912|negative regulation of smooth muscle cell migration;GO:0017148|negative regulation of translation;GO:0030336|negative regulation of cell migration;GO:0031069|hair follicle morphogenesis;GO:0035556|intracellular signal transduction;GO:0040008|regulation of growth;GO:0042593|glucose homeostasis;GO:0043567|regulation of insulin-like growth factor receptor signaling pathway;GO:0043568|positive regulation of insulin-like growth factor receptor signaling pathway;GO:0043569|negative regulation of insulin-like growth factor receptor signaling pathway;GO:0044342|type B pancreatic cell proliferation;GO:0045668|negative regulation of osteoblast differentiation;GO:0045926|negative regulation of growth;GO:0048286|lung alveolus development;GO:0048662|negative regulation of smooth muscle cell proliferation;GO:0051146|striated muscle cell differentiation;GO:0051897|positive regulation of protein kinase B signaling;GO:0060056|mammary gland involution;GO:0060416|response to growth hormone;GO:0071320|cellular response to cAMP;GO:0071407|cellular response to organic cyclic compound;GO:1901862|negative regulation of muscle tissue development;GO:1904205|negative regulation of skeletal muscle hypertrophy;GO:1904707|positive regulation of vascular smooth muscle cell proliferation;GO:1904754|positive regulation of vascular associated smooth muscle cell migration;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0042567|insulin-like growth factor ternary complex;","GO:0001968|fibronectin binding;GO:0005520|insulin-like growth factor binding;GO:0031994|insulin-like growth factor I binding;GO:0031995|insulin-like growth factor II binding;","K23577","IGFBP5; insulin-like growth factor-binding protein 5"]
["ENSRNOG00000066573",3349,215.4426375,16780,1083.348005,0.198867434,-2.330121054,0,0,"down","yes","C4a","protein_coding","chr20:4005731-4020080:+","gi|158186621|ref|NP_113692.2|",9032,0,"complement C4 precursor [Rattus norvegicus]","gi|259013549|ref|NM_031504.3|",5356,0,"Rattus norvegicus complement component 4A (Rodgers blood group) (C4a), mRNA","P08649",3482,0,"Complement C4","TM0984",58.2,3e-07,"COG2373","pfam07678","A2M_comp","A-macroglobulin complement component. This family includes the complement components region of the alpha-2-macroglobulin family.",".",".",".",".","."]
["ENSRNOG00000014532",321,20.65007066,9161,591.4511963,0.034914243,-4.840040506,0,0,"down","yes","Lbp","protein_coding","chr3:146954015-146981586:+","gi|139948891|ref|NP_058904.2|",2400,0,"lipopolysaccharide-binding protein precursor [Rattus norvegicus]","gi|510714|gb|L32132.1|RATLPSBP",2389,0,"Rat lipopolysaccharide binding protein mRNA, complete cds","Q63313",924,0,"Lipopolysaccharide-binding protein",".",".",".",".","pfam02886","LBP_BPI_CETP_C","LBP / BPI / CETP family, C-terminal domain. The N and C terminal domains of the LBP/BPI/CETP family are structurally similar.","GO:0001889|liver development;GO:0002232|leukocyte chemotaxis involved in inflammatory response;GO:0002281|macrophage activation involved in immune response;GO:0006953|acute-phase response;GO:0015920|lipopolysaccharide transport;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0032490|detection of molecule of bacterial origin;GO:0032496|response to lipopolysaccharide;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032722|positive regulation of chemokine production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0033036|macromolecule localization;GO:0034145|positive regulation of toll-like receptor 4 signaling pathway;GO:0043032|positive regulation of macrophage activation;GO:0045087|innate immune response;GO:0045919|positive regulation of cytolysis;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:0060100|positive regulation of phagocytosis, engulfment;GO:0060265|positive regulation of respiratory burst involved in inflammatory response;GO:0071222|cellular response to lipopolysaccharide;GO:0071223|cellular response to lipoteichoic acid;GO:0090023|positive regulation of neutrophil chemotaxis;GO:0090559|regulation of membrane permeability;","GO:0005615|extracellular space;GO:0009986|cell surface;GO:0016020|membrane;","GO:0001530|lipopolysaccharide binding;GO:0005102|signaling receptor binding;GO:0070891|lipoteichoic acid binding;GO:0071723|lipopeptide binding;","K05399","LBP; lipopolysaccharide-binding protein"]
["ENSRNOG00000058039",3424,220.2674203,16496,1065.012437,0.206821454,-2.27354225,0,0,"down","yes","Acta2","protein_coding","chr1:231746548-231759554:-","gi|625206860|ref|XP_003505997.2|",2443,0,"PREDICTED: actin, aortic smooth muscle isoform X1 [Cricetulus griseus]","gi|148298812|ref|NM_031004.2|",1374,0,"Rattus norvegicus actin, alpha 2, smooth muscle, aorta (Acta2), mRNA","P62738",787,0,"Actin, aortic smooth muscle","SPBC32H8.12c",710,0,"COG5277","pfam00022","Actin","Actin.","GO:0006936|muscle contraction;GO:0008217|regulation of blood pressure;GO:0009615|response to virus;GO:0010628|positive regulation of gene expression;GO:0014829|vascular smooth muscle contraction;GO:0061041|regulation of wound healing;GO:0061870|positive regulation of hepatic stellate cell migration;GO:0061874|positive regulation of hepatic stellate cell contraction;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0072144|glomerular mesangial cell development;GO:0090131|mesenchyme migration;GO:2000491|positive regulation of hepatic stellate cell activation;","GO:0001725|stress fiber;GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005869|dynactin complex;GO:0015629|actin cytoskeleton;GO:0030027|lamellipodium;GO:0030175|filopodium;GO:0030485|smooth muscle contractile fiber;GO:0032991|protein-containing complex;GO:0044297|cell body;","GO:0005524|ATP binding;GO:0019901|protein kinase binding;","K12313","ACTA2; actin, aortic smooth muscle"]
["ENSRNOG00000007457",1518,97.65360516,11807,762.281877,0.128106949,-2.964579365,0,0,"down","yes","Serping1","protein_coding","chr3:69842739-69852034:-","gi|40018558|ref|NP_954524.1|",2362,0,"plasma protease C1 inhibitor precursor [Rattus norvegicus]","gi|40018557|ref|NM_199093.1|",1783,0,"Rattus norvegicus serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 (Serping1), mRNA","Q6P734",914,0,"Plasma protease C1 inhibitor","MA3388",91.3,{"v":7e-19,"d":"7.00E-19"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0001869|negative regulation of complement activation, lectin pathway;GO:0006958|complement activation, classical pathway;GO:0007568|aging;GO:0007596|blood coagulation;GO:0010951|negative regulation of endopeptidase activity;GO:0042730|fibrinolysis;GO:0045087|innate immune response;","GO:0005615|extracellular space;","GO:0001848|complement binding;GO:0003674|molecular_function;GO:0004867|serine-type endopeptidase inhibitor activity;","K04001","SERPING1, C1INH; C1 inhibitor"]
["ENSRNOG00000017628",5159,331.8807306,19249,1242.751237,0.267053229,-1.904800766,0,0,"down","yes","Tagln","protein_coding","chr8:46222472-46230668:-","gi|674082951|ref|XP_008849145.1|",1049,{"v":1E-139,"d":"1.00E-139"},"PREDICTED: transgelin isoform X1 [Nannospalax galili]","gi|298881244|emb|FQ229775.1|",1033,0,"Rattus norvegicus TL0ADA46YL18 mRNA sequence","P31232",407,{"v":4e-141,"d":"4.00E-141"},"Transgelin","YOR367w",65.1,{"v":2e-11,"d":"2.00E-11"},"COG5199","pfam00307","CH","Calponin homology (CH) domain. The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.","GO:0030855|epithelial cell differentiation;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;","GO:0030674|protein binding, bridging;GO:0051015|actin filament binding;","K20526","TAGLN; transgelin"]
["ENSRNOG00000045683",3466,222.9692987,15664,1011.29697,0.220478559,-2.18128973,0,0,"down","yes","Mfap4","protein_coding","chr10:46167217-46170155:+","gi|564372249|ref|XP_006246538.1|",1408,0,"PREDICTED: microfibril-associated glycoprotein 4 isoform X1 [Rattus norvegicus]","gi|672067755|ref|XM_006246476.2|",1555,0,"PREDICTED: Rattus norvegicus microfibrillar-associated protein 4 (Mfap4), transcript variant X1, mRNA","Q9D1H9",476,{"v":1E-165,"d":"1.00E-165"},"Microfibril-associated glycoprotein 4",".",".",".",".","pfam00147","Fibrinogen_C","Fibrinogen beta and gamma chains, C-terminal globular domain.","GO:0009650|UV protection;GO:0010712|regulation of collagen metabolic process;GO:0048251|elastic fiber assembly;GO:0071493|cellular response to UV-B;GO:0097435|supramolecular fiber organization;","GO:0001527|microfibril;GO:0005576|extracellular region;GO:0062023|collagen-containing extracellular matrix;GO:0071953|elastic fiber;",".","K25409","MFAP4; microfibrillar-associated protein 4"]
["ENSRNOG00000014288",2066,132.9066853,12396,800.3088123,0.166069251,-2.59014312,0,0,"down","yes","Fn1","protein_coding","chr9:73196044-73264678:-","gi|186972114|ref|NP_062016.2|",12509,0,"fibronectin precursor [Rattus norvegicus]","gi|186972113|ref|NM_019143.2|",8331,0,"Rattus norvegicus fibronectin 1 (Fn1), mRNA","P04937",4813,0,"Fibronectin",".",".",".",".","pfam00040","fn2","Fibronectin type II domain.","GO:0001503|ossification;GO:0001525|angiogenesis;GO:0001775|cell activation;GO:0001932|regulation of protein phosphorylation;GO:0002931|response to ischemia;GO:0006953|acute-phase response;GO:0007044|cell-substrate junction assembly;GO:0007155|cell adhesion;GO:0007160|cell-matrix adhesion;GO:0007161|calcium-independent cell-matrix adhesion;GO:0007229|integrin-mediated signaling pathway;GO:0007399|nervous system development;GO:0007507|heart development;GO:0008284|positive regulation of cell proliferation;GO:0008347|glial cell migration;GO:0008360|regulation of cell shape;GO:0009410|response to xenobiotic stimulus;GO:0009611|response to wounding;GO:0010039|response to iron ion;GO:0010193|response to ozone;GO:0010468|regulation of gene expression;GO:0010628|positive regulation of gene expression;GO:0010952|positive regulation of peptidase activity;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0014823|response to activity;GO:0018149|peptide cross-linking;GO:0030198|extracellular matrix organization;GO:0030335|positive regulation of cell migration;GO:0032966|negative regulation of collagen biosynthetic process;GO:0033622|integrin activation;GO:0034446|substrate adhesion-dependent cell spreading;GO:0035924|cellular response to vascular endothelial growth factor stimulus;GO:0035987|endodermal cell differentiation;GO:0036120|cellular response to platelet-derived growth factor stimulus;GO:0042060|wound healing;GO:0043066|negative regulation of apoptotic process;GO:0045773|positive regulation of axon extension;GO:0048146|positive regulation of fibroblast proliferation;GO:0050921|positive regulation of chemotaxis;GO:0051384|response to glucocorticoid;GO:0051702|interaction with symbiont;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:0070527|platelet aggregation;GO:0071222|cellular response to lipopolysaccharide;GO:0071288|cellular response to mercury ion;GO:0071333|cellular response to glucose stimulus;GO:0071347|cellular response to interleukin-1;GO:0071380|cellular response to prostaglandin E stimulus;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0071635|negative regulation of transforming growth factor beta production;GO:0071773|cellular response to BMP stimulus;GO:0072378|blood coagulation, fibrin clot formation;GO:1901166|neural crest cell migration involved in autonomic nervous system development;GO:1904237|positive regulation of substrate-dependent cell migration, cell attachment to substrate;GO:1904385|cellular response to angiotensin;GO:1904646|cellular response to amyloid-beta;","GO:0005576|extracellular region;GO:0005577|fibrinogen complex;GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0005793|endoplasmic reticulum-Golgi intermediate compartment;GO:0016324|apical plasma membrane;GO:0031012|extracellular matrix;GO:0062023|collagen-containing extracellular matrix;GO:0070062|extracellular exosome;","GO:0002020|protease binding;GO:0005102|signaling receptor binding;GO:0005178|integrin binding;GO:0005201|extracellular matrix structural constituent;GO:0005515|protein binding;GO:0008022|protein C-terminus binding;GO:0008201|heparin binding;GO:0016504|peptidase activator activity;GO:0019899|enzyme binding;GO:0042802|identical protein binding;GO:0043394|proteoglycan binding;GO:0045340|mercury ion binding;GO:0051087|chaperone binding;GO:0097718|disordered domain specific binding;","K05717","FN1; fibronectin 1"]
["ENSRNOG00000018184",3840,247.0288826,15722,1015.041558,0.243368245,-2.038787158,0,0,"down","yes","Tpm1","protein_coding","chr8:67635479-67662802:-","gi|568961229|ref|XP_006511109.1|",992,{"v":2e-123,"d":"2.00E-123"},"PREDICTED: tropomyosin alpha-1 chain isoform X10 [Mus musculus]","gi|207358|gb|M34136.1|RATTMBR3A",2338,0,"Rat brain alpha-tropomyosin (TMBr-3) mRNA, 3' end","Q5KR49",274,{"v":2e-82,"d":"2.00E-82"},"Tropomyosin alpha-1 chain",".",".",".",".","pfam00261","Tropomyosin","Tropomyosin.","GO:0001701|in utero embryonic development;GO:0003065|positive regulation of heart rate by epinephrine;GO:0006936|muscle contraction;GO:0007015|actin filament organization;GO:0008360|regulation of cell shape;GO:0030049|muscle filament sliding;GO:0030336|negative regulation of cell migration;GO:0031529|ruffle organization;GO:0032781|positive regulation of ATPase activity;GO:0034614|cellular response to reactive oxygen species;GO:0042060|wound healing;GO:0043462|regulation of ATPase activity;GO:0045214|sarcomere organization;GO:0045785|positive regulation of cell adhesion;GO:0051496|positive regulation of stress fiber assembly;GO:0051693|actin filament capping;GO:0055010|ventricular cardiac muscle tissue morphogenesis;GO:0060048|cardiac muscle contraction;GO:1904706|negative regulation of vascular smooth muscle cell proliferation;GO:1904753|negative regulation of vascular associated smooth muscle cell migration;","GO:0001725|stress fiber;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0005884|actin filament;GO:0015629|actin cytoskeleton;GO:0030016|myofibril;GO:0032059|bleb;GO:0032587|ruffle membrane;GO:0032991|protein-containing complex;","GO:0003779|actin binding;GO:0008092|cytoskeletal protein binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0046982|protein heterodimerization activity;GO:0047485|protein N-terminus binding;GO:0051015|actin filament binding;GO:0097718|disordered domain specific binding;","K10373","TPM1; tropomyosin 1"]
["ENSRNOG00000019648",4658,299.6511811,16776,1083.089758,0.276663295,-1.853796841,0,0,"down","yes","Col6a3","protein_coding","chr9:91361583-91439471:-","gi|392342464|ref|XP_003754596.1|",10139,0,"PREDICTED: collagen alpha-3(VI) chain isoform X2 [Rattus norvegicus]","gi|672024296|ref|XM_006226938.2|",10978,0,"PREDICTED: Rattus norvegicus collagen, type VI, alpha 3 (Col6a3), transcript variant X1, mRNA","P12111",3308,0,"Collagen alpha-3(VI) chain",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0009749|response to glucose;","GO:0005575|cellular_component;GO:0005581|collagen trimer;GO:0005615|extracellular space;GO:0031012|extracellular matrix;GO:0042383|sarcolemma;","GO:0003674|molecular_function;","K06238","COL6A; collagen type VI alpha"]
["ENSRNOG00000033615",3734,240.2098562,14986,967.5240288,0.248272755,-2.010002143,0,0,"down","yes","Mt-nd3","protein_coding","chrMT:9451-9798:+","gi|226453430|ref|YP_002791023.1|",227,{"v":1e-21,"d":"1.00E-21"},"NADH dehydrogenase subunit 3 [Rattus rattus]","gi|755572967|gb|KP244683.1|",348,0,"Rattus norvegicus isolate 115 mitochondrion, complete genome","P03899",91.3,{"v":7e-23,"d":"7.00E-23"},"NADH-ubiquinone oxidoreductase chain 3",".",".",".",".","pfam00507","Oxidored_q4","NADH-ubiquinone/plastoquinone oxidoreductase, chain 3.","GO:0006120|mitochondrial electron transport, NADH to ubiquinone;GO:0006979|response to oxidative stress;GO:0009642|response to light intensity;GO:0009725|response to hormone;GO:0071385|cellular response to glucocorticoid stimulus;","GO:0005575|cellular_component;GO:0005743|mitochondrial inner membrane;GO:0005747|mitochondrial respiratory chain complex I;GO:0030964|NADH dehydrogenase complex;","GO:0003674|molecular_function;GO:0008137|NADH dehydrogenase (ubiquinone) activity;","K03880","ND3; NADH-ubiquinone oxidoreductase chain 3 [EC:7.1.1.2]"]
["ENSRNOG00000024346",289,18.59149664,6991,451.3519609,0.041190685,-4.601538056,0,0,"down","yes","Plet1","protein_coding","chr8:50841854-50853659:+","gi|62079153|ref|NP_001014231.1|",945,{"v":2e-122,"d":"2.00E-122"},"placenta-expressed transcript 1 protein precursor [Rattus norvegicus]","gi|298910792|emb|FQ228964.1|",1325,0,"Rattus norvegicus TL0ADA50YB20 mRNA sequence","Q5HZW7",351,{"v":3e-117,"d":"3.00E-117"},"Placenta-expressed transcript 1 protein",".",".",".",".","pfam02112","PDEase_II","cAMP phosphodiesterases class-II.","GO:0001953|negative regulation of cell-matrix adhesion;GO:0030154|cell differentiation;GO:0030335|positive regulation of cell migration;GO:0035313|wound healing, spreading of epidermal cells;","GO:0009897|external side of plasma membrane;GO:0016324|apical plasma membrane;GO:0031225|anchored component of membrane;",".",".","."]
["ENSRNOG00000003172",536,34.48111487,7652,494.0273501,0.069795963,-3.840712587,0,0,"down","yes","Serpinf1","protein_coding","chr10:60249708-60262646:-","gi|29293811|ref|NP_808788.1|",1981,0,"pigment epithelium-derived factor precursor [Rattus norvegicus]","gi|31342661|ref|NM_177927.2|",1338,0,"Rattus norvegicus serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 (Serpinf1), mRNA","P97298",724,0,"Pigment epithelium-derived factor","all0778",129,{"v":1e-31,"d":"1.00E-31"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0001822|kidney development;GO:0007568|aging;GO:0007614|short-term memory;GO:0010447|response to acidic pH;GO:0010596|negative regulation of endothelial cell migration;GO:0010629|negative regulation of gene expression;GO:0010951|negative regulation of endopeptidase activity;GO:0010976|positive regulation of neuron projection development;GO:0014070|response to organic cyclic compound;GO:0016525|negative regulation of angiogenesis;GO:0042698|ovulation cycle;GO:0046685|response to arsenic-containing substance;GO:0050728|negative regulation of inflammatory response;GO:0050769|positive regulation of neurogenesis;GO:0060041|retina development in camera-type eye;GO:0060770|negative regulation of epithelial cell proliferation involved in prostate gland development;GO:0071279|cellular response to cobalt ion;GO:0071300|cellular response to retinoic acid;GO:0071333|cellular response to glucose stimulus;GO:0071549|cellular response to dexamethasone stimulus;GO:1901215|negative regulation of neuron death;GO:1901652|response to peptide;","GO:0005576|extracellular region;GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0030424|axon;GO:0043025|neuronal cell body;GO:0043203|axon hillock;GO:0048471|perinuclear region of cytoplasm;","GO:0004867|serine-type endopeptidase inhibitor activity;","K19614","SERPINF1, PEDF; pigment epithelium-derived factor"]
["ENSRNOG00000054890",7933,510.3333661,22232,1435.339264,0.355548949,-1.491879905,0,0,"down","yes","Flna","protein_coding","chrX:152007758-152031052:-","gi|197386807|ref|NP_001128071.1|",13413,0,"filamin-A [Rattus norvegicus]","gi|197386806|ref|NM_001134599.1|",7479,0,"Rattus norvegicus filamin A (Flna), mRNA","Q8BTM8",5101,0,"Filamin-A","ECU09g0290",147,{"v":2E-35,"d":"2.00E-35"},"COG5069","pfam00630","Filamin","Filamin/ABP280 repeat.","GO:0001525|angiogenesis;GO:0001837|epithelial to mesenchymal transition;GO:0001974|blood vessel remodeling;GO:0003007|heart morphogenesis;GO:0007195|adenylate cyclase-inhibiting dopamine receptor signaling pathway;GO:0010977|negative regulation of neuron projection development;GO:0016479|negative regulation of transcription by RNA polymerase I;GO:0021943|formation of radial glial scaffolds;GO:0021987|cerebral cortex development;GO:0030036|actin cytoskeleton organization;GO:0030334|regulation of cell migration;GO:0031532|actin cytoskeleton reorganization;GO:0032231|regulation of actin filament bundle assembly;GO:0032233|positive regulation of actin filament bundle assembly;GO:0034394|protein localization to cell surface;GO:0042177|negative regulation of protein catabolic process;GO:0042307|positive regulation of protein import into nucleus;GO:0042789|mRNA transcription by RNA polymerase II;GO:0043066|negative regulation of apoptotic process;GO:0043113|receptor clustering;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043433|negative regulation of DNA-binding transcription factor activity;GO:0044319|wound healing, spreading of cells;GO:0045022|early endosome to late endosome transport;GO:0045184|establishment of protein localization;GO:0045216|cell-cell junction organization;GO:0048680|positive regulation of axon regeneration;GO:0050808|synapse organization;GO:0050821|protein stabilization;GO:0051220|cytoplasmic sequestering of protein;GO:0051764|actin crosslink formation;GO:0060271|cilium assembly;GO:0070527|platelet aggregation;GO:0071526|semaphorin-plexin signaling pathway;GO:0072659|protein localization to plasma membrane;GO:0090042|tubulin deacetylation;GO:0090307|mitotic spindle assembly;GO:0097368|establishment of Sertoli cell barrier;GO:1900026|positive regulation of substrate adhesion-dependent cell spreading;GO:1901381|positive regulation of potassium ion transmembrane transport;GO:1902396|protein localization to bicellular tight junction;GO:1905031|regulation of membrane repolarization during cardiac muscle cell action potential;GO:2000179|positive regulation of neural precursor cell proliferation;GO:2001046|positive regulation of integrin-mediated signaling pathway;GO:2001224|positive regulation of neuron migration;","GO:0005634|nucleus;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005802|trans-Golgi network;GO:0005829|cytosol;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0005903|brush border;GO:0005911|cell-cell junction;GO:0005938|cell cortex;GO:0015629|actin cytoskeleton;GO:0030018|Z disc;GO:0030426|growth cone;GO:0030863|cortical cytoskeleton;GO:0031523|Myb complex;GO:0032432|actin filament bundle;GO:0043025|neuronal cell body;GO:0043198|dendritic shaft;GO:0044295|axonal growth cone;GO:0048471|perinuclear region of cytoplasm;GO:0097440|apical dendrite;GO:0098794|postsynapse;GO:0098978|glutamatergic synapse;","GO:0001664|G protein-coupled receptor binding;GO:0005080|protein kinase C binding;GO:0005515|protein binding;GO:0015459|potassium channel regulator activity;GO:0019900|kinase binding;GO:0031267|small GTPase binding;GO:0031852|mu-type opioid receptor binding;GO:0034988|Fc-gamma receptor I complex binding;GO:0042803|protein homodimerization activity;GO:0044325|ion channel binding;GO:0044877|protein-containing complex binding;GO:0046332|SMAD binding;GO:0051015|actin filament binding;GO:0051020|GTPase binding;","K04437","FLNA; filamin"]
["ENSRNOG00000011971",5703,366.876489,18299,1181.41747,0.310539245,-1.687152492,0,0,"down","yes","C1s","protein_coding","chr4:157430117-157442303:-","gi|149049498|gb|EDM01952.1|",3572,0,"rCG29725, isoform CRA_b [Rattus norvegicus]","gi|38303990|gb|BC062042.1|",2808,0,"Rattus norvegicus complement component 1, s subcomponent, mRNA (cDNA clone MGC:72298 IMAGE:5598051), complete cds","Q6P6T1",1366,0,"Complement C1s subcomponent","VC1649",79.7,{"v":2E-14,"d":"2.00E-14"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;GO:0006958|complement activation, classical pathway;GO:0010001|glial cell differentiation;GO:0045087|innate immune response;GO:0051591|response to cAMP;","GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0003674|molecular_function;GO:0004252|serine-type endopeptidase activity;GO:0005509|calcium ion binding;GO:0042802|identical protein binding;","K01331","C1S; complement component 1, s subcomponent [EC:3.4.21.42]"]
["ENSRNOG00000010947",1707,109.812058,10367,669.312799,0.164066873,-2.607644124,0,0,"down","yes","Mmp14","protein_coding","chr15:27887727-27899864:+","gi|13591995|ref|NP_112318.1|",2651,0,"matrix metalloproteinase-14 precursor [Rattus norvegicus]","gi|47939002|gb|BC072509.1|",2385,0,"Rattus norvegicus matrix metallopeptidase 14 (membrane-inserted), mRNA (cDNA clone MGC:91652 IMAGE:7103279), complete cds","Q10739",1025,0,"Matrix metalloproteinase-14","MA4674",57.4,2E-8,"COG5549","pfam00413","Peptidase_M10","Matrixin. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.","GO:0001501|skeletal system development;GO:0001503|ossification;GO:0001525|angiogenesis;GO:0001541|ovarian follicle development;GO:0001666|response to hypoxia;GO:0001935|endothelial cell proliferation;GO:0001958|endochondral ossification;GO:0006508|proteolysis;GO:0006979|response to oxidative stress;GO:0008584|male gonad development;GO:0009612|response to mechanical stimulus;GO:0009725|response to hormone;GO:0010831|positive regulation of myotube differentiation;GO:0010954|positive regulation of protein processing;GO:0014070|response to organic cyclic compound;GO:0016477|cell migration;GO:0030198|extracellular matrix organization;GO:0030307|positive regulation of cell growth;GO:0030324|lung development;GO:0030335|positive regulation of cell migration;GO:0030574|collagen catabolic process;GO:0031638|zymogen activation;GO:0035987|endodermal cell differentiation;GO:0035988|chondrocyte proliferation;GO:0043615|astrocyte cell migration;GO:0043627|response to estrogen;GO:0045579|positive regulation of B cell differentiation;GO:0045746|negative regulation of Notch signaling pathway;GO:0048701|embryonic cranial skeleton morphogenesis;GO:0048754|branching morphogenesis of an epithelial tube;GO:0048771|tissue remodeling;GO:0051895|negative regulation of focal adhesion assembly;GO:0060322|head development;GO:0060348|bone development;GO:0097094|craniofacial suture morphogenesis;GO:1903076|regulation of protein localization to plasma membrane;GO:1905523|positive regulation of macrophage migration;GO:1990834|response to odorant;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0031012|extracellular matrix;GO:0031410|cytoplasmic vesicle;GO:0042470|melanosome;GO:0044354|macropinosome;GO:0045111|intermediate filament cytoskeleton;","GO:0004175|endopeptidase activity;GO:0004222|metalloendopeptidase activity;GO:0005178|integrin binding;GO:0008270|zinc ion binding;GO:0070006|metalloaminopeptidase activity;","K07763","MMP14; matrix metalloproteinase-14 (membrane-inserted) [EC:3.4.24.80]"]
["ENSRNOG00000058470",771,49.59876784,7885,509.0702634,0.097430102,-3.359488609,0,0,"down","yes","Col12a1","protein_coding","chr8:80547593-80665686:-","gi|672023106|ref|XP_008756047.1|",14897,0,"PREDICTED: collagen alpha-1(XII) chain isoform X1 [Rattus norvegicus]","gi|672023105|ref|XM_008757825.1|",12409,0,"PREDICTED: Rattus norvegicus collagen, type XII, alpha 1 (Col12a1), transcript variant X1, mRNA","Q60847",5464,0,"Collagen alpha-1(XII) chain",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0007155|cell adhesion;GO:0035987|endodermal cell differentiation;","GO:0005576|extracellular region;GO:0005581|collagen trimer;GO:0005595|collagen type XII trimer;GO:0005615|extracellular space;GO:0062023|collagen-containing extracellular matrix;","GO:0005201|extracellular matrix structural constituent;","K08132","COL12A; collagen type XII alpha"]
["ENSRNOG00000024899",74,4.760452426,6188,399.5087875,0.011915764,-6.390984735,0,0,"down","yes","Cxcl13","protein_coding","chr14:13608902-13613933:-","gi|564383008|ref|XP_006250772.1|",486,{"v":5e-57,"d":"5.00E-57"},"PREDICTED: C-X-C motif chemokine 13 isoform X1 [Rattus norvegicus]","gi|672075817|ref|XM_006250710.2|",1087,0,"PREDICTED: Rattus norvegicus chemokine (C-X-C motif) ligand 13 (Cxcl13), transcript variant X1, mRNA","O55038",139,{"v":2e-38,"d":"2.00E-38"},"C-X-C motif chemokine 13",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0002518|lymphocyte chemotaxis across high endothelial venule;GO:0006954|inflammatory response;GO:0007166|cell surface receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007267|cell-cell signaling;GO:0010820|positive regulation of T cell chemotaxis;GO:0030593|neutrophil chemotaxis;GO:0031640|killing of cells of other organism;GO:0033625|positive regulation of integrin activation;GO:0033634|positive regulation of cell-cell adhesion mediated by integrin;GO:0035754|B cell chemotaxis;GO:0035768|endothelial cell chemotaxis to fibroblast growth factor;GO:0035769|B cell chemotaxis across high endothelial venule;GO:0042742|defense response to bacterium;GO:0048535|lymph node development;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098|chemokine-mediated signaling pathway;GO:0071222|cellular response to lipopolysaccharide;GO:0090630|activation of GTPase activity;GO:2000545|negative regulation of endothelial cell chemotaxis to fibroblast growth factor;","GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0008009|chemokine activity;GO:0008201|heparin binding;GO:0017134|fibroblast growth factor binding;GO:0031724|CXCR5 chemokine receptor binding;GO:0031735|CCR10 chemokine receptor binding;GO:0045236|CXCR chemokine receptor binding;GO:0048018|receptor ligand activity;GO:0048248|CXCR3 chemokine receptor binding;","K10032","CXCL13; C-X-C motif chemokine 13"]
["ENSRNOG00000004610",5119,329.3075131,16673,1076.439886,0.305922808,-1.708760422,0,0,"down","yes","Lum","protein_coding","chr7:32358614-32365793:+","gi|13591983|ref|NP_112312.1|",1416,{"v":7e-179,"d":"7.00E-179"},"lumican precursor [Rattus norvegicus]","gi|334883614|gb|AC125963.6|",4430,0,"Rattus norvegicus BAC CH230-89G23 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P51886",550,{"v":2E-180,"d":"2.00E-180"},"Lumican","alr0124_1",65.1,{"v":9e-10,"d":"9.00E-10"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0007601|visual perception;GO:0014070|response to organic cyclic compound;GO:0030199|collagen fibril organization;GO:0032914|positive regulation of transforming growth factor beta1 production;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051216|cartilage development;GO:0070848|response to growth factor;","GO:0005583|fibrillar collagen trimer;GO:0005615|extracellular space;GO:0031012|extracellular matrix;","GO:0003674|molecular_function;GO:0005518|collagen binding;","K08122","LUM; lumican"]
["ENSRNOG00000019810",709,45.61028067,7495,483.8911381,0.094257318,-3.407251565,0,0,"down","yes","Des","protein_coding","chr9:76850982-76858699:+","gi|344251698|gb|EGW07802.1|",1768,0,"Desmin [Cricetulus griseus]","gi|38197675|gb|BC061872.1|",1356,0,"Rattus norvegicus desmin, mRNA (cDNA clone MGC:72444 IMAGE:5598951), complete cds","P02541",670,0,"Desmin",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0045109|intermediate filament organization;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005882|intermediate filament;GO:0005911|cell-cell junction;GO:0005916|fascia adherens;GO:0005921|gap junction;GO:0014704|intercalated disc;GO:0030018|Z disc;GO:0031594|neuromuscular junction;GO:0042383|sarcolemma;GO:0043292|contractile fiber;GO:0045098|type III intermediate filament;GO:0045111|intermediate filament cytoskeleton;GO:0097512|cardiac myofibril;","GO:0008092|cytoskeletal protein binding;GO:0042802|identical protein binding;","K07610","DES; desmin"]
["ENSRNOG00000029401",970,62.40052504,7993,516.0429442,0.120921186,-3.047861056,0,0,"down","yes","Actg2","protein_coding","chr4:116021832-116046465:-","gi|528767717|gb|EPY87376.1|",2078,0,"hypothetical protein CB1_000252031 [Camelus ferus]","gi|672050141|ref|XM_006236728.2|",1343,0,"PREDICTED: Rattus norvegicus actin, gamma 2, smooth muscle, enteric (Actg2), transcript variant X1, mRNA","P63269",786,0,"Actin, gamma-enteric smooth muscle","SPBC32H8.12c",711,0,"COG5277","pfam00022","Actin","Actin.","GO:0008150|biological_process;GO:0010628|positive regulation of gene expression;GO:0014829|vascular smooth muscle contraction;GO:0090131|mesenchyme migration;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005869|dynactin complex;GO:0030027|lamellipodium;GO:0030175|filopodium;GO:0032982|myosin filament;GO:0044297|cell body;GO:0071944|cell periphery;","GO:0003674|molecular_function;GO:0005524|ATP binding;","K12315","ACTG2; actin, gamma-enteric smooth muscle"]
["ENSRNOG00000010507",2,0.128660876,12164,785.3304608,0.00016383,-12.57551072,0,0,"down","yes","Mmp7","protein_coding","chr8:4848186-4855902:+","gi|6981214|ref|NP_036996.1|",1414,0,"matrilysin precursor [Rattus norvegicus]","gi|166091437|ref|NM_012864.2|",804,0,"Rattus norvegicus matrix metallopeptidase 7 (Mmp7), mRNA","P50280",549,0,"Matrilysin",".",".",".",".","pfam00413","Peptidase_M10","Matrixin. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.","GO:0002779|antibacterial peptide secretion;GO:0002780|antibacterial peptide biosynthetic process;GO:0006508|proteolysis;GO:0006509|membrane protein ectodomain proteolysis;GO:0007568|aging;GO:0009410|response to xenobiotic stimulus;GO:0030198|extracellular matrix organization;GO:0030335|positive regulation of cell migration;GO:0030574|collagen catabolic process;GO:0031293|membrane protein intracellular domain proteolysis;GO:0031667|response to nutrient levels;GO:0042127|regulation of cell proliferation;GO:0042742|defense response to bacterium;GO:0044849|estrous cycle;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:0060135|maternal process involved in female pregnancy;GO:0071260|cellular response to mechanical stimulus;","GO:0005615|extracellular space;GO:0009986|cell surface;GO:0031012|extracellular matrix;","GO:0004175|endopeptidase activity;GO:0004222|metalloendopeptidase activity;GO:0008201|heparin binding;GO:0008233|peptidase activity;GO:0008237|metallopeptidase activity;GO:0008270|zinc ion binding;","K01397","MMP7; matrix metalloproteinase-7 (matrilysin, uterine) [EC:3.4.24.23]"]
["ENSRNOG00000032844",1731,111.3559885,9519,614.5643421,0.181195004,-2.464384917,0,0,"down","yes","RT1-Da","protein_coding","chr20:4512911-4518455:+","gi|40556829|gb|AAR87772.1|",1061,{"v":6e-131,"d":"6.00E-131"},"MHC class II antigen alpha chain [Rattus norvegicus]","gi|46237557|emb|BX883043.1|",3116,0,"Rattus norvegicus chromosome 20, major histocompatibility complex, assembled from 40 BACs, strain Brown Norway (BN/ssNHsd), RT1n haplotype; segment 2/11","P14439",384,{"v":2E-121,"d":"2.00E-121"},"H-2 class II histocompatibility antigen, E-U alpha chain",".",".",".",".","pfam00993","MHC_II_alpha","Class II histocompatibility antigen, alpha domain.","GO:0001916|positive regulation of T cell mediated cytotoxicity;GO:0002250|adaptive immune response;GO:0002381|immunoglobulin production involved in immunoglobulin mediated immune response;GO:0002469|myeloid dendritic cell antigen processing and presentation;GO:0002491|antigen processing and presentation of endogenous peptide antigen via MHC class II;GO:0002503|peptide antigen assembly with MHC class II protein complex;GO:0002504|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;GO:0008150|biological_process;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0032831|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0043382|positive regulation of memory T cell differentiation;GO:0045622|regulation of T-helper cell differentiation;GO:0050870|positive regulation of T cell activation;GO:0050890|cognition;GO:2000516|positive regulation of CD4-positive, alpha-beta T cell activation;","GO:0001772|immunological synapse;GO:0005575|cellular_component;GO:0005764|lysosome;GO:0005765|lysosomal membrane;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0031902|late endosome membrane;GO:0042613|MHC class II protein complex;","GO:0003674|molecular_function;GO:0023026|MHC class II protein complex binding;GO:0030247|polysaccharide binding;GO:0042605|peptide antigen binding;GO:0042608|T cell receptor binding;","K06752","MHC2; MHC class II antigen"]
["ENSRNOG00000000321",74,4.760452426,5478,353.6698672,0.013460158,-6.215160804,0,0,"down","yes","Cd24","protein_coding","chr20:47073512-47079662:+","gi|149046938|gb|EDL99686.1|",608,{"v":2e-71,"d":"2.00E-71"},"rCG58523 [Rattus norvegicus]","gi|1216497|gb|U49062.1|RNU49062",1672,0,"Rattus norvegicus heat stable antigen CD24 mRNA, complete cds","Q07490",85.1,{"v":4e-18,"d":"4.00E-18"},"Signal transducer CD24",".",".",".",".","pfam14984","CD24","CD24 protein.","GO:0001666|response to hypoxia;GO:0001775|cell activation;GO:0001959|regulation of cytokine-mediated signaling pathway;GO:0002237|response to molecule of bacterial origin;GO:0002329|pre-B cell differentiation;GO:0002523|leukocyte migration involved in inflammatory response;GO:0002842|positive regulation of T cell mediated immune response to tumor cell;GO:0002863|positive regulation of inflammatory response to antigenic stimulus;GO:0002904|positive regulation of B cell apoptotic process;GO:0006955|immune response;GO:0007155|cell adhesion;GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007159|leukocyte cell-cell adhesion;GO:0007166|cell surface receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007267|cell-cell signaling;GO:0007274|neuromuscular synaptic transmission;GO:0007406|negative regulation of neuroblast proliferation;GO:0008637|apoptotic mitochondrial changes;GO:0010976|positive regulation of neuron projection development;GO:0016477|cell migration;GO:0022407|regulation of cell-cell adhesion;GO:0022409|positive regulation of cell-cell adhesion;GO:0030262|apoptotic nuclear changes;GO:0030889|negative regulation of B cell proliferation;GO:0031175|neuron projection development;GO:0031295|T cell costimulation;GO:0032597|B cell receptor transport into membrane raft;GO:0032600|chemokine receptor transport out of membrane raft;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032913|negative regulation of transforming growth factor beta3 production;GO:0033625|positive regulation of integrin activation;GO:0033630|positive regulation of cell adhesion mediated by integrin;GO:0033632|regulation of cell-cell adhesion mediated by integrin;GO:0033634|positive regulation of cell-cell adhesion mediated by integrin;GO:0034107|negative regulation of erythrocyte clearance;GO:0034109|homotypic cell-cell adhesion;GO:0034119|negative regulation of erythrocyte aggregation;GO:0042103|positive regulation of T cell homeostatic proliferation;GO:0042104|positive regulation of activated T cell proliferation;GO:0042325|regulation of phosphorylation;GO:0042632|cholesterol homeostasis;GO:0043406|positive regulation of MAP kinase activity;GO:0043408|regulation of MAPK cascade;GO:0043627|response to estrogen;GO:0045577|regulation of B cell differentiation;GO:0045665|negative regulation of neuron differentiation;GO:0045730|respiratory burst;GO:0046014|negative regulation of T cell homeostatic proliferation;GO:0046641|positive regulation of alpha-beta T cell proliferation;GO:0048488|synaptic vesicle endocytosis;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050768|negative regulation of neurogenesis;GO:0050850|positive regulation of calcium-mediated signaling;GO:0061098|positive regulation of protein tyrosine kinase activity;GO:0071638|negative regulation of monocyte chemotactic protein-1 production;GO:0072112|glomerular visceral epithelial cell differentiation;GO:0072139|glomerular parietal epithelial cell differentiation;GO:0097190|apoptotic signaling pathway;GO:0098609|cell-cell adhesion;GO:0106015|negative regulation of inflammatory response to wounding;GO:0106016|positive regulation of inflammatory response to wounding;GO:2000768|positive regulation of nephron tubule epithelial cell differentiation;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0031362|anchored component of external side of plasma membrane;GO:0031528|microvillus membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0045121|membrane raft;GO:0046658|anchored component of plasma membrane;GO:0060170|ciliary membrane;GO:0098793|presynapse;","GO:0019901|protein kinase binding;GO:0030246|carbohydrate binding;GO:0030296|protein tyrosine kinase activator activity;GO:0030544|Hsp70 protein binding;GO:0051879|Hsp90 protein binding;","K06469","CD24; CD24 antigen"]
["ENSRNOG00000010635",3467,223.0336292,12940,835.4304639,0.266968514,-1.905258495,0,0,"down","yes","Igfbp4","protein_coding","chr10:83989591-84007225:+","gi|51948524|ref|NP_001004274.1|",1133,{"v":5e-146,"d":"5.00E-146"},"insulin-like growth factor-binding protein 4 precursor [Rattus norvegicus]","gi|70778853|ref|NM_001004274.2|",1792,0,"Rattus norvegicus insulin-like growth factor binding protein 4 (Igfbp4), mRNA","P21744",441,{"v":2e-147,"d":"2.00E-147"},"Insulin-like growth factor-binding protein 4",".",".",".",".","pfam00086","Thyroglobulin_1","Thyroglobulin type-1 repeat. Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.","GO:0001558|regulation of cell growth;GO:0006954|inflammatory response;GO:0010906|regulation of glucose metabolic process;GO:0035556|intracellular signal transduction;GO:0040008|regulation of growth;GO:0043410|positive regulation of MAPK cascade;GO:0043567|regulation of insulin-like growth factor receptor signaling pathway;GO:0043568|positive regulation of insulin-like growth factor receptor signaling pathway;GO:0044342|type B pancreatic cell proliferation;","GO:0005615|extracellular space;","GO:0005520|insulin-like growth factor binding;GO:0031994|insulin-like growth factor I binding;GO:0031995|insulin-like growth factor II binding;","K23576","IGFBP4; insulin-like growth factor-binding protein 4"]
["ENSRNOG00000010529",47,3.023530595,5439,351.1519547,0.00861032,-6.859717478,0,0,"down","yes","Thbs2","protein_coding","chr1:55670394-55699789:-","gi|281332082|ref|NP_001162609.1|",5716,0,"thrombospondin-2 precursor [Rattus norvegicus]","gi|281332081|ref|NM_001169138.1|",5728,0,"Rattus norvegicus thrombospondin 2 (Thbs2), mRNA","Q03350",2156,0,"Thrombospondin-2",".",".",".",".","pfam05735","TSP_C","Thrombospondin C-terminal region. This region is found at the C-terminus of thrombospondin and related proteins.","GO:0007155|cell adhesion;GO:0016525|negative regulation of angiogenesis;GO:0051965|positive regulation of synapse assembly;","GO:0005576|extracellular region;GO:0005604|basement membrane;GO:0031012|extracellular matrix;GO:0031091|platelet alpha granule;GO:0062023|collagen-containing extracellular matrix;","GO:0005509|calcium ion binding;GO:0008201|heparin binding;","K04659","THBS2S; thrombospondin 2/3/4/5"]
["ENSRNOG00000002215",3467,223.0336292,12486,806.1193797,0.276675682,-1.853732249,0,0,"down","yes","Mylk","protein_coding","chr11:65783008-66030261:-","gi|672071096|ref|XP_008766933.1|",9928,0,"PREDICTED: myosin light chain kinase, smooth muscle isoform X2 [Rattus norvegicus]","gi|672071094|ref|XM_006248434.2|",7839,0,"PREDICTED: Rattus norvegicus myosin light chain kinase (Mylk), transcript variant X2, mRNA","Q6PDN3",3466,0,"Myosin light chain kinase, smooth muscle",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006468|protein phosphorylation;GO:0006939|smooth muscle contraction;GO:0014820|tonic smooth muscle contraction;GO:0030335|positive regulation of cell migration;GO:0032060|bleb assembly;GO:0035865|cellular response to potassium ion;GO:0051928|positive regulation of calcium ion transport;GO:0060414|aorta smooth muscle tissue morphogenesis;GO:0071277|cellular response to calcium ion;GO:0071466|cellular response to xenobiotic stimulus;GO:0071476|cellular hypotonic response;GO:0090303|positive regulation of wound healing;","GO:0001725|stress fiber;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0015629|actin cytoskeleton;GO:0030027|lamellipodium;GO:0032154|cleavage furrow;","GO:0004672|protein kinase activity;GO:0004687|myosin light chain kinase activity;GO:0005516|calmodulin binding;GO:0005524|ATP binding;GO:0019899|enzyme binding;GO:0046872|metal ion binding;","K00907","MYLK; myosin-light-chain kinase [EC:2.7.11.18]"]
["ENSRNOG00000013973",426,27.40476667,5450,351.8621351,0.077884955,-3.682511514,0,0,"down","yes","Lcn2","protein_coding","chr3:15680687-15684095:-","gi|306526224|sp|P30152.2|NGAL_RAT",763,{"v":4e-97,"d":"4.00E-97"},"RecName: Full=Neutrophil gelatinase-associated lipocalin; Short=NGAL; AltName: Full=Alpha-2-microglobulin-related protein; AltName: Full=Alpha-2U globulin-related protein; AltName: Full=Lipocalin-2; AltName: Full=Siderocalin LCN2; AltName: Full=p25; Flags: Precursor","gi|57870615|gb|BC089053.1|",583,0,"Rattus norvegicus lipocalin 2, mRNA (cDNA clone MGC:105339 IMAGE:7310185), complete cds","P30152",298,{"v":1e-98,"d":"1.00E-98"},"Neutrophil gelatinase-associated lipocalin",".",".",".",".","pfam00061","Lipocalin","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.","GO:0006953|acute-phase response;GO:0006979|response to oxidative stress;GO:0007614|short-term memory;GO:0007616|long-term memory;GO:0009410|response to xenobiotic stimulus;GO:0009615|response to virus;GO:0009617|response to bacterium;GO:0009635|response to herbicide;GO:0009636|response to toxic substance;GO:0009637|response to blue light;GO:0009750|response to fructose;GO:0010040|response to iron(II) ion;GO:0010046|response to mycotoxin;GO:0010595|positive regulation of endothelial cell migration;GO:0010628|positive regulation of gene expression;GO:0015891|siderophore transport;GO:0031346|positive regulation of cell projection organization;GO:0031667|response to nutrient levels;GO:0031669|cellular response to nutrient levels;GO:0036295|cellular response to increased oxygen levels;GO:0042742|defense response to bacterium;GO:0043065|positive regulation of apoptotic process;GO:0043525|positive regulation of neuron apoptotic process;GO:0045087|innate immune response;GO:0070301|cellular response to hydrogen peroxide;GO:0071222|cellular response to lipopolysaccharide;GO:0071347|cellular response to interleukin-1;GO:0071354|cellular response to interleukin-6;GO:0071356|cellular response to tumor necrosis factor;GO:0071481|cellular response to X-ray;GO:0090650|cellular response to oxygen-glucose deprivation;GO:0097192|extrinsic apoptotic signaling pathway in absence of ligand;GO:0097577|sequestering of iron ion;GO:0110091|negative regulation of hippocampal neuron apoptotic process;GO:0120162|positive regulation of cold-induced thermogenesis;GO:1901216|positive regulation of neuron death;GO:1903428|positive regulation of reactive oxygen species biosynthetic process;GO:1904440|positive regulation of ferrous iron import across plasma membrane;GO:1904646|cellular response to amyloid-beta;GO:1905956|positive regulation of endothelial tube morphogenesis;GO:1990090|cellular response to nerve growth factor stimulus;GO:2000379|positive regulation of reactive oxygen species metabolic process;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0060205|cytoplasmic vesicle lumen;","GO:0002020|protease binding;GO:0005506|iron ion binding;GO:0036094|small molecule binding;GO:0042802|identical protein binding;GO:1903981|enterobactin binding;","K21129","LCN2; lipocalin 2"]
["ENSRNOG00000049402",1262,81.18501299,7438,480.2111121,0.169061088,-2.564383457,0,0,"down","yes","Nbl1","protein_coding","chr5:151318754-151338719:-","gi|672054622|ref|XP_008762506.1|",724,{"v":4e-88,"d":"4.00E-88"},"PREDICTED: neuroblastoma suppressor of tumorigenicity 1 isoform X1 [Rattus norvegicus]","gi|672054621|ref|XM_008764284.1|",1607,0,"PREDICTED: Rattus norvegicus neuroblastoma 1, DAN family BMP antagonist (Nbl1), transcript variant X1, mRNA","Q06880",266,{"v":2e-83,"d":"2.00E-83"},"Neuroblastoma suppressor of tumorigenicity 1",".",".",".",".","pfam03045","DAN","DAN domain. This domain contains 9 conserved cysteines and is extracellular. Therefore the cysteines may form disulphide bridges. This family of proteins has been termed the DAN family after the first member to be reported. This family includes DAN, Cerberus and Gremlin. The gremlin protein is an antagonist of bone morphogenetic protein signaling. It is postulated that all members of this family antagonise different TGF beta pfam00019 ligands. Recent work shows that the DAN protein is not an efficient antagonist of BMP-2/4 class signals, we found that DAN was able to interact with GDF-5 in a frog embryo assay, suggesting that DAN may regulate signaling by the GDF-5/6/7 class of BMPs in vivo.","GO:0007165|signal transduction;GO:0007399|nervous system development;GO:0009887|animal organ morphogenesis;GO:0030514|negative regulation of BMP signaling pathway;GO:0035582|sequestering of BMP in extracellular matrix;GO:0038098|sequestering of BMP from receptor via BMP binding;GO:0045666|positive regulation of neuron differentiation;GO:0048263|determination of dorsal identity;GO:0048812|neuron projection morphogenesis;GO:0090027|negative regulation of monocyte chemotaxis;","GO:0005615|extracellular space;","GO:0016015|morphogen activity;GO:0036122|BMP binding;GO:0042802|identical protein binding;GO:0048018|receptor ligand activity;","K19558","NBL1; neuroblastoma suppressor of tumorigenicity 1"]
["ENSRNOG00000003736",2418,155.5509995,9811,633.4164051,0.24557463,-2.025766567,0,0,"down","yes","Col5a2","protein_coding","chr9:47448736-47598154:-","gi|149046234|gb|EDL99127.1|",3070,0,"procollagen, type V, alpha 2 [Rattus norvegicus]","gi|281371498|ref|NM_053488.1|",6085,0,"Rattus norvegicus collagen, type V, alpha 2 (Col5a2), mRNA","Q3U962",1159,0,"Collagen alpha-2(V) chain",".",".",".",".","pfam01410","COLFI","Fibrillar collagen C-terminal domain. Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1 alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.","GO:0001501|skeletal system development;GO:0001503|ossification;GO:0030198|extracellular matrix organization;GO:0030199|collagen fibril organization;GO:0043588|skin development;GO:0048592|eye morphogenesis;GO:0071230|cellular response to amino acid stimulus;GO:1903225|negative regulation of endodermal cell differentiation;","GO:0005581|collagen trimer;GO:0005588|collagen type V trimer;GO:0005615|extracellular space;GO:0031012|extracellular matrix;","GO:0005201|extracellular matrix structural constituent;GO:0046332|SMAD binding;GO:0046872|metal ion binding;","K19721","COL5AS; collagen type V/XI/XXIV/XXVII, alpha"]
["ENSRNOG00000032417",78,5.017774178,4423,285.5571053,0.017571876,-5.830587927,0,0,"down","yes","Gabrp","protein_coding","chr10:18143038-18169516:-","gi|672066981|ref|XP_008765817.1|",2180,0,"PREDICTED: gamma-aminobutyric acid receptor subunit pi isoform X2 [Rattus norvegicus]","gi|672066978|ref|XM_008767594.1|",2791,0,"PREDICTED: Rattus norvegicus gamma-aminobutyric acid (GABA-A) receptor, pi (Gabrp), transcript variant X1, mRNA","O09028",837,0,"Gamma-aminobutyric acid receptor subunit pi",".",".",".",".","pfam02931","Neur_chan_LBD","Neurotransmitter-gated ion-channel ligand binding domain. This family is the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.","GO:0006821|chloride transport;GO:0007165|signal transduction;GO:0007268|chemical synaptic transmission;GO:0034220|ion transmembrane transport;GO:0042391|regulation of membrane potential;GO:0050877|nervous system process;GO:1902476|chloride transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0034707|chloride channel complex;GO:0043005|neuron projection;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:1902711|GABA-A receptor complex;","GO:0004890|GABA-A receptor activity;GO:0005230|extracellular ligand-gated ion channel activity;GO:0005254|chloride channel activity;GO:0030594|neurotransmitter receptor activity;","K05189","GABRP; gamma-aminobutyric acid receptor subunit pi"]
["ENSRNOG00000034190",33,2.12290446,4498,290.3992447,7.310296E-3,-7.095854446,0,0,"down","yes","Ighm","protein_coding","chr6:132329269-133053426:-","gi|56789191|gb|AAH88240.1|",2159,0,"IgG-2a protein [Rattus norvegicus]","gi|56789190|gb|BC088240.1|",1239,0,"Rattus norvegicus gamma-2a immunoglobulin heavy chain, mRNA (cDNA clone MGC:109023 IMAGE:7365825), complete cds","P20760",633,0,"Ig gamma-2A chain C region",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.","GO:0019731|antibacterial humoral response;GO:0050829|defense response to Gram-negative bacterium;","GO:0016021|integral component of membrane;GO:0071756|pentameric IgM immunoglobulin complex;GO:0071757|hexameric IgM immunoglobulin complex;","GO:0003697|single-stranded DNA binding;GO:0031210|phosphatidylcholine binding;GO:0042834|peptidoglycan binding;",".","."]
["ENSRNOG00000012956",2465,158.5745301,9609,620.3749094,0.255610805,-1.967979272,0,0,"down","yes","Tgm2","protein_coding","chr3:146772687-146801981:-","gi|5326787|gb|AAD42046.1|AF106325_1",3591,0,"tissue-type transglutaminase [Rattus norvegicus]","gi|42476286|ref|NM_019386.2|",3417,0,"Rattus norvegicus transglutaminase 2 (Tgm2), mRNA","P21981",1342,0,"Protein-glutamine gamma-glutamyltransferase 2",".",".",".",".","pfam00868","Transglut_N","Transglutaminase family.","GO:0001974|blood vessel remodeling;GO:0006508|proteolysis;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0018149|peptide cross-linking;GO:0018153|isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine;GO:0018277|protein deamination;GO:0032471|negative regulation of endoplasmic reticulum calcium ion concentration;GO:0042981|regulation of apoptotic process;GO:0043065|positive regulation of apoptotic process;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043277|apoptotic cell clearance;GO:0043547|positive regulation of GTPase activity;GO:0045785|positive regulation of cell adhesion;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0050729|positive regulation of inflammatory response;GO:0050769|positive regulation of neurogenesis;GO:0051057|positive regulation of small GTPase mediated signal transduction;GO:0051260|protein homooligomerization;GO:0051482|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway;GO:0051561|positive regulation of mitochondrial calcium ion concentration;GO:0060348|bone development;GO:0060445|branching involved in salivary gland morphogenesis;GO:0060662|salivary gland cavitation;GO:0071314|cellular response to cocaine;GO:1903351|cellular response to dopamine;GO:1904015|cellular response to serotonin;GO:2000425|regulation of apoptotic cell clearance;","GO:0000785|chromatin;GO:0005576|extracellular region;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0031012|extracellular matrix;GO:0031226|intrinsic component of plasma membrane;GO:0048471|perinuclear region of cytoplasm;","GO:0003810|protein-glutamine gamma-glutamyltransferase activity;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0005525|GTP binding;GO:0008233|peptidase activity;GO:0019899|enzyme binding;GO:0019904|protein domain specific binding;GO:0042802|identical protein binding;GO:0050568|protein-glutamine glutaminase activity;","K05625","TGM2; transglutaminase 2 [EC:2.3.2.13]"]
["ENSRNOG00000017469",1198,77.06786495,6817,440.1181973,0.175107199,-2.513689694,0,0,"down","yes","Anxa1","protein_coding","chr1:217861175-217877343:-","gi|564333152|ref|XP_006231221.1|",1870,0,"PREDICTED: annexin A1 isoform X2 [Rattus norvegicus]","gi|672039948|ref|XM_008760295.1|",1328,0,"PREDICTED: Rattus norvegicus annexin A1 (Anxa1), transcript variant X2, mRNA","P07150",715,0,"Annexin A1",".",".",".",".","pfam00191","Annexin","Annexin. This family of annexins also includes giardin that has been shown to function as an annexin.","GO:0001780|neutrophil homeostasis;GO:0002250|adaptive immune response;GO:0002548|monocyte chemotaxis;GO:0002685|regulation of leukocyte migration;GO:0006909|phagocytosis;GO:0006954|inflammatory response;GO:0007165|signal transduction;GO:0007166|cell surface receptor signaling pathway;GO:0007187|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0008360|regulation of cell shape;GO:0009410|response to xenobiotic stimulus;GO:0009725|response to hormone;GO:0010165|response to X-ray;GO:0014070|response to organic cyclic compound;GO:0014839|myoblast migration involved in skeletal muscle regeneration;GO:0018149|peptide cross-linking;GO:0030073|insulin secretion;GO:0030216|keratinocyte differentiation;GO:0030850|prostate gland development;GO:0031018|endocrine pancreas development;GO:0031340|positive regulation of vesicle fusion;GO:0031394|positive regulation of prostaglandin biosynthetic process;GO:0031532|actin cytoskeleton reorganization;GO:0031960|response to corticosteroid;GO:0032355|response to estradiol;GO:0032508|DNA duplex unwinding;GO:0032652|regulation of interleukin-1 production;GO:0032717|negative regulation of interleukin-8 production;GO:0032743|positive regulation of interleukin-2 production;GO:0033031|positive regulation of neutrophil apoptotic process;GO:0035924|cellular response to vascular endothelial growth factor stimulus;GO:0042063|gliogenesis;GO:0042102|positive regulation of T cell proliferation;GO:0042127|regulation of cell proliferation;GO:0043065|positive regulation of apoptotic process;GO:0043434|response to peptide hormone;GO:0044849|estrous cycle;GO:0045087|innate immune response;GO:0045627|positive regulation of T-helper 1 cell differentiation;GO:0045629|negative regulation of T-helper 2 cell differentiation;GO:0045920|negative regulation of exocytosis;GO:0046632|alpha-beta T cell differentiation;GO:0046883|regulation of hormone secretion;GO:0050482|arachidonic acid secretion;GO:0050709|negative regulation of protein secretion;GO:0050727|regulation of inflammatory response;GO:0051384|response to glucocorticoid;GO:0070301|cellular response to hydrogen peroxide;GO:0070365|hepatocyte differentiation;GO:0070459|prolactin secretion;GO:0070555|response to interleukin-1;GO:0071385|cellular response to glucocorticoid stimulus;GO:0071621|granulocyte chemotaxis;GO:0090050|positive regulation of cell migration involved in sprouting angiogenesis;GO:0090303|positive regulation of wound healing;GO:0097350|neutrophil clearance;GO:1900087|positive regulation of G1/S transition of mitotic cell cycle;GO:1900138|negative regulation of phospholipase A2 activity;","GO:0001533|cornified envelope;GO:0001891|phagocytic cup;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005829|cytosol;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0016328|lateral plasma membrane;GO:0019898|extrinsic component of membrane;GO:0031232|extrinsic component of external side of plasma membrane;GO:0031313|extrinsic component of endosome membrane;GO:0031514|motile cilium;GO:0031901|early endosome membrane;GO:0031966|mitochondrial membrane;GO:0032991|protein-containing complex;GO:0042383|sarcolemma;GO:0042629|mast cell granule;GO:0070062|extracellular exosome;GO:0070382|exocytic vesicle;GO:0097060|synaptic membrane;","GO:0003697|single-stranded DNA binding;GO:0003727|single-stranded RNA binding;GO:0005509|calcium ion binding;GO:0005543|phospholipid binding;GO:0005544|calcium-dependent phospholipid binding;GO:0019834|phospholipase A2 inhibitor activity;GO:0036121|double-stranded DNA-dependent ATP-dependent DNA helicase activity;GO:0042802|identical protein binding;GO:0048306|calcium-dependent protein binding;GO:1990814|DNA/DNA annealing activity;","K17091","ANXA1; annexin A1"]
["ENSRNOG00000016831",9759,627.8007462,20777,1341.401758,0.468018431,-1.095362749,0,0,"down","yes","Serpinh1","protein_coding","chr1:153643510-153650801:-","gi|55824765|gb|AAH86529.1|",1949,0,"Serpinh1 protein [Rattus norvegicus]","gi|8393056|ref|NM_017173.1|",1434,0,"Rattus norvegicus serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) (Serpinh1), mRNA","P29457",749,0,"Serpin H1","all0778",124,{"v":1e-29,"d":"1.00E-29"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0003433|chondrocyte development involved in endochondral bone morphogenesis;GO:0010951|negative regulation of endopeptidase activity;GO:0030199|collagen fibril organization;GO:0032964|collagen biosynthetic process;GO:0051604|protein maturation;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005788|endoplasmic reticulum lumen;GO:0005793|endoplasmic reticulum-Golgi intermediate compartment;GO:0045121|membrane raft;","GO:0004867|serine-type endopeptidase inhibitor activity;GO:0005518|collagen binding;GO:0051082|unfolded protein binding;","K09501","SERPINH1, HSP47; serpin peptidase inhibitor, clade H, member 1"]
["ENSRNOG00000001469",877,56.41779429,5852,377.8160027,0.149326111,-2.743461641,0,0,"down","yes","Eln","protein_coding","chr12:21968544-22011928:+","gi|674078310|ref|XP_008846618.1|",306,{"v":1E-26,"d":"1.00E-26"},"PREDICTED: elastin [Nannospalax galili]","gi|55742708|ref|NM_012722.1|",3581,0,"Rattus norvegicus elastin (Eln), mRNA",".",".",".",".",".",".",".",".","pfam02711","Pap_E4","E4 protein. This is is a family of Papillomavirus proteins, E4, coded for by ORF4. A splice variant, E1--E4, exists but neither the function of E4 or E1--E4 is known.","GO:0001974|blood vessel remodeling;GO:0003151|outflow tract morphogenesis;GO:0007519|skeletal muscle tissue development;GO:0007568|aging;GO:0009410|response to xenobiotic stimulus;GO:0030198|extracellular matrix organization;GO:0030833|regulation of actin filament polymerization;GO:0035904|aorta development;GO:0043149|stress fiber assembly;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0048251|elastic fiber assembly;GO:0055093|response to hyperoxia;GO:0071280|cellular response to copper ion;GO:0071298|cellular response to L-ascorbic acid;GO:0071300|cellular response to retinoic acid;GO:0071407|cellular response to organic cyclic compound;GO:0071456|cellular response to hypoxia;GO:0071549|cellular response to dexamethasone stimulus;GO:0071560|cellular response to transforming growth factor beta stimulus;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0031012|extracellular matrix;GO:0062023|collagen-containing extracellular matrix;GO:0071953|elastic fiber;","GO:0005201|extracellular matrix structural constituent;GO:0030023|extracellular matrix constituent conferring elasticity;GO:0050840|extracellular matrix binding;","K14211","ELN; elastin"]
["ENSRNOG00000027736",426,27.40476667,4689,302.7305599,0.090525273,-3.465535563,0,0,"down","yes","Cnn1","protein_coding","chr8:20632338-20641098:+","gi|967495236|ref|XP_014978452.1|",1449,0,"PREDICTED: calponin-1 [Macaca mulatta]","gi|13929049|ref|NM_031747.1|",1395,0,"Rattus norvegicus calponin 1 (Cnn1), mRNA","Q08290",561,0,"Calponin-1","ECU03g1150",70.5,{"v":4e-13,"d":"4.00E-13"},"COG5199","pfam00307","CH","Calponin homology (CH) domain. The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.","GO:0031032|actomyosin structure organization;GO:1904706|negative regulation of vascular smooth muscle cell proliferation;","GO:0005856|cytoskeleton;","GO:0003779|actin binding;GO:0005516|calmodulin binding;",".","."]
["ENSRNOG00000049829",6,0.385982629,5127,331.0086545,0.00116608,-9.744117301,0,0,"down","yes","AABR07060872.1","protein_coding","chr4:102404346-102688488:+","gi|92401|pir||S06084",887,{"v":1e-116,"d":"1.00E-116"},"Ig kappa chain precursor - rat","gi|298890810|emb|FQ230756.1|",742,0,"Rattus norvegicus TL0AEA8YC24 mRNA sequence","P0DOX7",248,{"v":5E-80,"d":"5.00E-80"},"Immunoglobulin kappa light chain",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.",".",".",".",".","."]
["ENSRNOG00000016731",2511,161.5337303,9078,586.092562,0.275611295,-1.859293079,0,0,"down","yes","Tpm2","protein_coding","chr5:57770864-57779992:-","gi|942069538|ref|XP_014335267.1|",819,{"v":2e-96,"d":"2.00E-96"},"PREDICTED: tropomyosin beta chain isoform X1 [Bos mutus]","gi|672052479|ref|XM_008763680.1|",998,0,"PREDICTED: Rattus norvegicus tropomyosin 2, beta (Tpm2), transcript variant X2, mRNA","P58775",303,{"v":6e-92,"d":"6.00E-92"},"Tropomyosin beta chain",".",".",".",".","pfam00261","Tropomyosin","Tropomyosin.","GO:0006936|muscle contraction;GO:0007015|actin filament organization;GO:0043462|regulation of ATPase activity;","GO:0005737|cytoplasm;GO:0005884|actin filament;GO:0015629|actin cytoskeleton;","GO:0003779|actin binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0046982|protein heterodimerization activity;GO:0051015|actin filament binding;","K10374","TPM2; tropomyosin 2"]
["ENSRNOG00000064136",1701,109.4260754,7487,483.3746432,0.226379428,-2.143185233,0,0,"down","yes","ENSRNOG00000064136","lncRNA","chr3:11354747-11357054:+","gi|344248922|gb|EGW05026.1|",171,{"v":5e-11,"d":"5.00E-11"},"hypothetical protein I79_024639 [Cricetulus griseus]","gi|672045035|ref|XM_006233873.2|",1732,0,"PREDICTED: Rattus norvegicus collagen, type V, alpha 1 (Col5a1), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam05758","Ycf1","Ycf1. The chloroplast genomes of most higher plants contain two giant open reading frames designated ycf1 and ycf2. Although the function of Ycf1 is unknown, it is known to be an essential gene.",".",".",".",".","."]
["ENSRNOG00000020246",4966,319.464956,13162,849.7631968,0.37594586,-1.41140318,0,0,"down","yes","Myl9","protein_coding","chr3:145281937-145288333:+","gi|431894354|gb|ELK04154.1|",855,{"v":1e-110,"d":"1.00E-110"},"Myosin regulatory light polypeptide 9 [Pteropus alecto]","gi|672047454|ref|XM_006235402.2|",1136,0,"PREDICTED: Rattus norvegicus myosin, light chain 9, regulatory (Myl9), transcript variant X2, mRNA","Q9CQ19",331,{"v":1e-111,"d":"1.00E-111"},"Myosin regulatory light polypeptide 9","SPAC3A12.14",116,{"v":6e-30,"d":"6.00E-30"},"COG5126","pfam13405","EF-hand_6","EF-hand domain.","GO:0070527|platelet aggregation;","GO:0001725|stress fiber;GO:0005938|cell cortex;GO:0016460|myosin II complex;GO:0030018|Z disc;","GO:0005509|calcium ion binding;GO:0032036|myosin heavy chain binding;","K12755","MYL9; myosin regulatory light chain 9"]
["ENSRNOG00000021220",565,36.34669757,4762,307.4435757,0.118222336,-3.080425467,0,0,"down","yes","Cpxm1","protein_coding","chr3:117588532-117595330:-","gi|157816889|ref|NP_001099981.1|",3583,0,"probable carboxypeptidase X1 precursor [Rattus norvegicus]","gi|157816888|ref|NM_001106511.1|",2367,0,"Rattus norvegicus carboxypeptidase X (M14 family), member 1 (Cpxm1), mRNA","Q9Z100",1319,0,"Probable carboxypeptidase X1",".",".",".",".","pfam00246","Peptidase_M14","Zinc carboxypeptidase.","GO:0006518|peptide metabolic process;GO:0016485|protein processing;","GO:0005615|extracellular space;","GO:0004181|metallocarboxypeptidase activity;GO:0008270|zinc ion binding;","K08638","CPXM1; carboxypeptidase X1 [EC:3.4.17.-]"]
["ENSRNOG00000031475",1974,126.988285,7732,499.1922989,0.254387508,-1.974900267,0,0,"down","yes","Col16a1","protein_coding","chr5:142388426-142442825:+","gi|564353029|ref|XP_006239012.1|",1989,0,"PREDICTED: collagen alpha-1(XVI) chain isoform X4 [Rattus norvegicus]","gi|672054148|ref|XM_006238950.2|",5271,0,"PREDICTED: Rattus norvegicus collagen, type XVI, alpha 1 (Col16a1), transcript variant X5, mRNA","Q8BLX7",717,0,"Collagen alpha-1(XVI) chain",".",".",".",".","pfam01391","Collagen","Collagen triple helix repeat (20 copies). Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxyproline. Collagens are post translationally modified by proline hydroxylase to form the hydroxyproline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure.","GO:0007155|cell adhesion;GO:0030198|extracellular matrix organization;GO:0033622|integrin activation;GO:0033627|cell adhesion mediated by integrin;GO:0051894|positive regulation of focal adhesion assembly;GO:0071230|cellular response to amino acid stimulus;","GO:0005588|collagen type V trimer;GO:0005615|extracellular space;GO:0031012|extracellular matrix;","GO:0005178|integrin binding;GO:0005201|extracellular matrix structural constituent;","K24339","COL16A; collagen type XVI alpha"]
["ENSRNOG00000058003",971,62.46485548,5661,365.4846875,0.170909638,-2.548694342,0,0,"down","yes","Spon1","protein_coding","chr1:167928972-168228226:+","gi|78070801|gb|AAI07656.1|",3916,0,"Spondin 1, extracellular matrix protein [Rattus norvegicus]","gi|78070800|gb|BC107655.1|",4091,0,"Rattus norvegicus spondin 1, extracellular matrix protein, mRNA (cDNA clone MGC:124557 IMAGE:7935103), complete cds","P35446",1511,0,"Spondin-1",".",".",".",".","pfam06468","Spond_N","Spondin_N. This conserved region is found at the in the N-terminal half of several Spondin proteins. Spondins are involved in patterning axonal growth trajectory through either inhibiting or promoting adhesion of embryonic nerve cells.","GO:0007155|cell adhesion;GO:0010954|positive regulation of protein processing;GO:0032092|positive regulation of protein binding;GO:1902430|negative regulation of amyloid-beta formation;GO:1902993|positive regulation of amyloid precursor protein catabolic process;","GO:0005576|extracellular region;GO:0031012|extracellular matrix;","GO:0046872|metal ion binding;GO:0050693|LBD domain binding;","K24427","SPON1; spondin-1"]
["ENSRNOG00000002746",1525,98.10391823,6726,434.243068,0.225919365,-2.146120156,0,0,"down","yes","Fstl1","protein_coding","chr11:62779783-62948677:-","gi|149060525|gb|EDM11239.1|",1492,0,"follistatin-like 1 [Rattus norvegicus]","gi|56799408|ref|NM_024369.2|",2131,0,"Rattus norvegicus follistatin-like 1 (Fstl1), mRNA","Q62632",575,0,"Follistatin-related protein 1",".",".",".",".","pfam07648","Kazal_2","Kazal-type serine protease inhibitor domain. Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.","GO:0007275|multicellular organism development;GO:0030154|cell differentiation;GO:0030510|regulation of BMP signaling pathway;GO:0043066|negative regulation of apoptotic process;GO:0043542|endothelial cell migration;GO:0045446|endothelial cell differentiation;GO:0061484|hematopoietic stem cell homeostasis;","GO:0005576|extracellular region;","GO:0005509|calcium ion binding;GO:0008201|heparin binding;","K23912","FSTL1; follistatin-related protein 1"]
["ENSRNOG00000014137",1232,79.25509984,6119,395.0540192,0.200618386,-2.317474262,0,0,"down","yes","Fbln1","protein_coding","chr7:116310582-116390075:+","gi|189011620|ref|NP_001121019.1|",3329,0,"fibulin-1 precursor [Rattus norvegicus]","gi|189011619|ref|NM_001127547.1|",2102,0,"Rattus norvegicus fibulin 1 (Fbln1), mRNA","Q08879",1250,0,"Fibulin-1",".",".",".",".","pfam07645","EGF_CA","Calcium-binding EGF domain.","GO:0001933|negative regulation of protein phosphorylation;GO:0007162|negative regulation of cell adhesion;GO:0007566|embryo implantation;GO:0010628|positive regulation of gene expression;GO:0010952|positive regulation of peptidase activity;GO:0030198|extracellular matrix organization;GO:0048146|positive regulation of fibroblast proliferation;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0071635|negative regulation of transforming growth factor beta production;GO:0072378|blood coagulation, fibrin clot formation;GO:1900025|negative regulation of substrate adhesion-dependent cell spreading;GO:1904188|negative regulation of transformation of host cell by virus;GO:1904237|positive regulation of substrate-dependent cell migration, cell attachment to substrate;GO:2000146|negative regulation of cell motility;GO:2000647|negative regulation of stem cell proliferation;","GO:0005575|cellular_component;GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0031012|extracellular matrix;GO:0071953|elastic fiber;","GO:0001968|fibronectin binding;GO:0003674|molecular_function;GO:0005178|integrin binding;GO:0005201|extracellular matrix structural constituent;GO:0005509|calcium ion binding;GO:0008022|protein C-terminus binding;GO:0016504|peptidase activator activity;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;GO:0070051|fibrinogen binding;","K17307","FBLN1_2; fibulin 1/2"]
["ENSRNOG00000017767",651,41.87911526,4750,306.6688334,0.136561368,-2.872378684,0,0,"down","yes","Irag1","protein_coding","chr1:164981716-165094176:-","gi|157419144|ref|NP_001098681.1|",3666,0,"protein MRVI1 isoform a [Rattus norvegicus]","gi|157419113|ref|NM_001105210.1|",6182,0,"Rattus norvegicus murine retrovirus integration site 1 homolog (Mrvi1), transcript variant 2, mRNA","Q9WUX5",1325,0,"Protein MRVI1",".",".",".",".","pfam05781","MRVI1","MRVI1 protein. This family consists of mammalian MRVI1 proteins which are related to the lymphoid-restricted membrane protein (JAW1) and the IP3 receptor associated cGMP kinase substrates A and B (IRAGA and IRAGB). The function of MRVI1 is unknown although mutations in the Mrvi1 gene induces myeloid leukaemia by altering the expression of a gene important for myeloid cell growth and/or differentiation so it has been speculated that Mrvi1 is a tumor suppressor gene. IRAG is very similar in sequence to MRVI1 and is an essential NO/cGKI-dependent regulator of IP3-induced calcium release. Activation of cGKI decreases IP3-stimulated elevations in intracellular calcium, induces smooth muscle relaxation and contributes to the antiproliferative and pro-apoptotic effects of NO/cGMP. Jaw1 is a member of a class of proteins with COOH-terminal hydrophobic membrane anchors and is structurally similar to proteins involved in vesicle targeting and fusion. This suggests that the function and/or the structure of the ER in lymphocytes may be modified by lymphoid-restricted resident ER proteins.","GO:0019934|cGMP-mediated signaling;GO:0045986|negative regulation of smooth muscle contraction;GO:0060087|relaxation of vascular smooth muscle;","GO:0005737|cytoplasm;GO:0016021|integral component of membrane;",".","K12337","MRVI1, IRAG; inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate"]
["ENSRNOG00000009779",428,27.53342754,4173,269.4166403,0.102196462,-3.290582838,0,0,"down","yes","Krt8","protein_coding","chr7:133124203-133131728:-","gi|30352203|gb|AAP31862.1|",1872,0,"cytokeratin-8 [Rattus sp.]","gi|913533|gb|S76054.1|",1323,0,"cytokeratin-8 [rats, prostatic epithelia, mRNA, 1747 nt]","Q10758",721,0,"Keratin, type II cytoskeletal 8",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0033209|tumor necrosis factor-mediated signaling pathway;GO:0045214|sarcomere organization;GO:0051599|response to hydrostatic pressure;GO:0051707|response to other organism;GO:0060706|cell differentiation involved in embryonic placenta development;GO:0097191|extrinsic apoptotic signaling pathway;GO:0097284|hepatocyte apoptotic process;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005882|intermediate filament;GO:0005911|cell-cell junction;GO:0016010|dystrophin-associated glycoprotein complex;GO:0016327|apicolateral plasma membrane;GO:0016363|nuclear matrix;GO:0030018|Z disc;GO:0042383|sarcolemma;GO:0043034|costamere;GO:0045095|keratin filament;GO:0045111|intermediate filament cytoskeleton;GO:0071944|cell periphery;","GO:0005515|protein binding;GO:0044877|protein-containing complex binding;GO:0097110|scaffold protein binding;","K07605","KRT2; type II keratin, basic"]
["ENSRNOG00000013720",1720,110.6483537,7018,453.0951311,0.244205568,-2.033832002,0,0,"down","yes","Aebp1","protein_coding","chr14:80738892-80748877:+","gi|155369293|ref|NP_001094440.1|",4613,0,"adipocyte enhancer-binding protein 1 precursor [Rattus norvegicus]","gi|155369292|ref|NM_001100970.1|",3792,0,"Rattus norvegicus AE binding protein 1 (Aebp1), mRNA","A2RUV9",1760,0,"Adipocyte enhancer-binding protein 1",".",".",".",".","pfam00246","Peptidase_M14","Zinc carboxypeptidase.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006355|regulation of transcription, DNA-templated;GO:0006508|proteolysis;GO:1904026|regulation of collagen fibril organization;","GO:0005576|extracellular region;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0004180|carboxypeptidase activity;GO:0004181|metallocarboxypeptidase activity;GO:0005516|calmodulin binding;GO:0005518|collagen binding;GO:0008270|zinc ion binding;","K21392","AEBP1; adipocyte enhancer-binding protein 1"]
["ENSRNOG00000011483",48,3.087861033,3134,202.3368682,0.015260991,-6.034007583,0,0,"down","yes","S100a9","protein_coding","chr2:176190361-176193230:-","gi|564337450|ref|XP_006232842.1|",706,{"v":8e-92,"d":"8.00E-92"},"PREDICTED: protein S100-A9 isoform X1 [Rattus norvegicus]","gi|564337449|ref|XM_006232780.1|",576,0,"PREDICTED: Rattus norvegicus S100 calcium binding protein A9 (S100a9), transcript variant X1, mRNA","P50116",237,{"v":4E-78,"d":"4.00E-78"},"Protein S100-A9",".",".",".",".","pfam01023","S_100","S-100/ICaBP type calcium binding domain. The S-100 domain is a subfamily of the EF-hand calcium binding proteins.","GO:0002523|leukocyte migration involved in inflammatory response;GO:0002544|chronic inflammatory response;GO:0002793|positive regulation of peptide secretion;GO:0006417|regulation of translation;GO:0006914|autophagy;GO:0006915|apoptotic process;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0010043|response to zinc ion;GO:0010976|positive regulation of neuron projection development;GO:0014002|astrocyte development;GO:0018119|peptidyl-cysteine S-nitrosylation;GO:0030194|positive regulation of blood coagulation;GO:0030593|neutrophil chemotaxis;GO:0030595|leukocyte chemotaxis;GO:0031532|actin cytoskeleton reorganization;GO:0032496|response to lipopolysaccharide;GO:0035425|autocrine signaling;GO:0035606|peptidyl-cysteine S-trans-nitrosylation;GO:0035821|modification of morphology or physiology of other organism;GO:0045087|innate immune response;GO:0045113|regulation of integrin biosynthetic process;GO:0045471|response to ethanol;GO:0050729|positive regulation of inflammatory response;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070488|neutrophil aggregation;GO:0098869|cellular oxidant detoxification;GO:2001244|positive regulation of intrinsic apoptotic signaling pathway;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0030054|cell junction;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;GO:0016209|antioxidant activity;GO:0048306|calcium-dependent protein binding;","K21128","S100A9; protein S100-A9"]
["ENSRNOG00000011648",209,13.44506158,3488,225.1917665,0.059704943,-4.066005812,0,0,"down","yes","Aqp1","protein_coding","chr4:84482512-84494690:+","gi|6978527|ref|NP_036910.1|",1397,0,"aquaporin-1 [Rattus norvegicus]","gi|59809406|gb|BC090068.1|",2607,0,"Rattus norvegicus aquaporin 1, mRNA (cDNA clone MGC:93653 IMAGE:7190406), complete cds","P29975",542,0,"Aquaporin-1","SP1778",110,{"v":7e-26,"d":"7.00E-26"},"COG0580","pfam00230","MIP","Major intrinsic protein. MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.","GO:0003094|glomerular filtration;GO:0003097|renal water transport;GO:0006813|potassium ion transport;GO:0006833|water transport;GO:0006884|cell volume homeostasis;GO:0006972|hyperosmotic response;GO:0009725|response to hormone;GO:0009992|cellular water homeostasis;GO:0010592|positive regulation of lamellipodium assembly;GO:0010634|positive regulation of epithelial cell migration;GO:0015670|carbon dioxide transport;GO:0015696|ammonium transport;GO:0015793|glycerol transport;GO:0019233|sensory perception of pain;GO:0019725|cellular homeostasis;GO:0019934|cGMP-mediated signaling;GO:0021670|lateral ventricle development;GO:0030104|water homeostasis;GO:0030157|pancreatic juice secretion;GO:0030185|nitric oxide transport;GO:0030335|positive regulation of cell migration;GO:0030950|establishment or maintenance of actin cytoskeleton polarity;GO:0032940|secretion by cell;GO:0033326|cerebrospinal fluid secretion;GO:0033363|secretory granule organization;GO:0034644|cellular response to UV;GO:0035377|transepithelial water transport;GO:0035378|carbon dioxide transmembrane transport;GO:0042060|wound healing;GO:0042476|odontogenesis;GO:0042538|hyperosmotic salinity response;GO:0043066|negative regulation of apoptotic process;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043627|response to estrogen;GO:0044241|lipid digestion;GO:0045766|positive regulation of angiogenesis;GO:0046878|positive regulation of saliva secretion;GO:0048146|positive regulation of fibroblast proliferation;GO:0048593|camera-type eye morphogenesis;GO:0050829|defense response to Gram-negative bacterium;GO:0050891|multicellular organismal water homeostasis;GO:0051458|corticotropin secretion;GO:0055085|transmembrane transport;GO:0070295|renal water absorption;GO:0070301|cellular response to hydrogen peroxide;GO:0071241|cellular response to inorganic substance;GO:0071260|cellular response to mechanical stimulus;GO:0071280|cellular response to copper ion;GO:0071288|cellular response to mercury ion;GO:0071300|cellular response to retinoic acid;GO:0071320|cellular response to cAMP;GO:0071456|cellular response to hypoxia;GO:0071472|cellular response to salt stress;GO:0071474|cellular hyperosmotic response;GO:0071549|cellular response to dexamethasone stimulus;GO:0071732|cellular response to nitric oxide;GO:0071805|potassium ion transmembrane transport;GO:0072220|metanephric descending thin limb development;GO:0072230|metanephric proximal straight tubule development;GO:0072232|metanephric proximal convoluted tubule segment 2 development;GO:0072239|metanephric glomerulus vasculature development;GO:0072488|ammonium transmembrane transport;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005901|caveola;GO:0005903|brush border;GO:0009925|basal plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0030424|axon;GO:0031526|brush border membrane;GO:0031965|nuclear membrane;GO:0032809|neuronal cell body membrane;GO:0042383|sarcolemma;GO:0043005|neuron projection;GO:0043679|axon terminus;GO:0045177|apical part of cell;GO:0070062|extracellular exosome;","GO:0005223|intracellular cGMP-activated cation channel activity;GO:0005267|potassium channel activity;GO:0005372|water transmembrane transporter activity;GO:0005515|protein binding;GO:0008519|ammonium transmembrane transporter activity;GO:0015079|potassium ion transmembrane transporter activity;GO:0015168|glycerol transmembrane transporter activity;GO:0015250|water channel activity;GO:0015267|channel activity;GO:0022857|transmembrane transporter activity;GO:0030184|nitric oxide transmembrane transporter activity;GO:0035379|carbon dioxide transmembrane transporter activity;GO:0042802|identical protein binding;GO:0046875|ephrin receptor binding;","K09864","AQP1; aquaporin-1"]
["ENSRNOG00000026415",69,4.438800235,3032,195.7515585,0.022675683,-5.462710201,0,0,"down","yes","Col14a1","protein_coding","chr7:86722094-86937214:+","gi|194474004|ref|NP_001124020.1|",7984,0,"collagen alpha-1(XIV) chain precursor [Rattus norvegicus]","gi|194474003|ref|NM_001130548.1|",4669,0,"Rattus norvegicus collagen, type XIV, alpha 1 (Col14a1), mRNA","Q80X19",2824,0,"Collagen alpha-1(XIV) chain",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0003229|ventricular cardiac muscle tissue development;GO:0030199|collagen fibril organization;GO:0048873|homeostasis of number of cells within a tissue;GO:0061050|regulation of cell growth involved in cardiac muscle cell development;","GO:0005581|collagen trimer;GO:0005614|interstitial matrix;GO:0005615|extracellular space;GO:0062023|collagen-containing extracellular matrix;",".","K08133","COL14A; collagen type XIV alpha"]
["ENSRNOG00000010977",966,62.14320329,5183,334.6241186,0.185710473,-2.428872919,0,0,"down","yes","Igfbp6","protein_coding","chr7:133276234-133280966:+","gi|6981090|ref|NP_037236.1|",1121,{"v":9e-152,"d":"9.00E-152"},"insulin-like growth factor-binding protein 6 precursor [Rattus norvegicus]","gi|298891918|emb|FQ220764.1|",958,0,"Rattus norvegicus TL0ADA41YM04 mRNA sequence","P35572",434,{"v":1e-152,"d":"1.00E-152"},"Insulin-like growth factor-binding protein 6",".",".",".",".","pfam00086","Thyroglobulin_1","Thyroglobulin type-1 repeat. Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.","GO:0008150|biological_process;GO:0016477|cell migration;GO:0032874|positive regulation of stress-activated MAPK cascade;GO:0043410|positive regulation of MAPK cascade;GO:0043567|regulation of insulin-like growth factor receptor signaling pathway;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0042568|insulin-like growth factor binary complex;","GO:0001968|fibronectin binding;GO:0031994|insulin-like growth factor I binding;GO:0031995|insulin-like growth factor II binding;GO:0042802|identical protein binding;","K23579","IGFBP6; insulin-like growth factor-binding protein 6"]
["ENSRNOG00000013589",2152,138.439103,7520,485.5051846,0.285144438,-1.810235203,0,0,"down","yes","Cxcl12","protein_coding","chr4:150388325-150401168:+","gi|148667157|gb|EDK99573.1|",487,{"v":2E-52,"d":"2.00E-52"},"chemokine (C-X-C motif) ligand 12, isoform CRA_c, partial [Mus musculus]","gi|76563909|ref|NM_001033883.1|",4802,0,"Rattus norvegicus chemokine (C-X-C motif) ligand 12 (Cxcl12), transcript variant 3, mRNA","P40224",151,{"v":3e-40,"d":"3.00E-40"},"Stromal cell-derived factor 1",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0001569|branching involved in blood vessel morphogenesis;GO:0001666|response to hypoxia;GO:0001667|ameboidal-type cell migration;GO:0001764|neuron migration;GO:0001938|positive regulation of endothelial cell proliferation;GO:0006952|defense response;GO:0006955|immune response;GO:0007281|germ cell development;GO:0007411|axon guidance;GO:0007420|brain development;GO:0008045|motor neuron axon guidance;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0008344|adult locomotory behavior;GO:0008354|germ cell migration;GO:0009314|response to radiation;GO:0009408|response to heat;GO:0009612|response to mechanical stimulus;GO:0010818|T cell chemotaxis;GO:0016477|cell migration;GO:0022029|telencephalon cell migration;GO:0030334|regulation of cell migration;GO:0030335|positive regulation of cell migration;GO:0031100|animal organ regeneration;GO:0031640|killing of cells of other organism;GO:0033603|positive regulation of dopamine secretion;GO:0033622|integrin activation;GO:0038146|chemokine (C-X-C motif) ligand 12 signaling pathway;GO:0042098|T cell proliferation;GO:0043434|response to peptide hormone;GO:0045666|positive regulation of neuron differentiation;GO:0045785|positive regulation of cell adhesion;GO:0048842|positive regulation of axon extension involved in axon guidance;GO:0050921|positive regulation of chemotaxis;GO:0050930|induction of positive chemotaxis;GO:0050965|detection of temperature stimulus involved in sensory perception of pain;GO:0050966|detection of mechanical stimulus involved in sensory perception of pain;GO:0051897|positive regulation of protein kinase B signaling;GO:0051924|regulation of calcium ion transport;GO:0060326|cell chemotaxis;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098|chemokine-mediated signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071542|dopaminergic neuron differentiation;GO:0090026|positive regulation of monocyte chemotaxis;GO:0090280|positive regulation of calcium ion import;GO:0098609|cell-cell adhesion;GO:1901741|positive regulation of myoblast fusion;GO:1902230|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:1903237|negative regulation of leukocyte tethering or rolling;GO:1990478|response to ultrasound;GO:1990869|cellular response to chemokine;GO:2000406|positive regulation of T cell migration;GO:2000669|negative regulation of dendritic cell apoptotic process;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;","GO:0005178|integrin binding;GO:0008009|chemokine activity;GO:0008083|growth factor activity;GO:0042379|chemokine receptor binding;GO:0045236|CXCR chemokine receptor binding;","K10031","CXCL12; C-X-C motif chemokine 12"]
["ENSRNOG00000016945",158,10.16420923,3058,197.4301668,0.051482554,-4.279772563,0,0,"down","yes","Pla2g2a","protein_coding","chr5:151076442-151079014:+","gi|291621686|ref|NP_113786.3|",770,{"v":2E-100,"d":"2.00E-100"},"phospholipase A2, membrane associated precursor [Rattus norvegicus]","gi|672054379|ref|XM_006239146.2|",859,0,"PREDICTED: Rattus norvegicus phospholipase A2, group IIA (platelets, synovial fluid) (Pla2g2a), transcript variant X1, mRNA","P14423",301,{"v":8e-102,"d":"8.00E-102"},"Phospholipase A2, membrane associated",".",".",".",".","pfam00068","Phospholip_A2_1","Phospholipase A2. Phospholipase A2 releases fatty acids from the second carbon group of glycerol. Perhaps the best known members are secreted snake venoms, but also found in secreted pancreatic and membrane-associated forms. Structure is all-alpha, with two core disulfide-linked helices and a calcium-binding loop. This alignment represents the major family of PLA2s. A second minor family, defined by the honeybee venom PLA2 PDB:1POC and related sequences from Gila monsters (Heloderma), is not recognized. This minor family conserves the core helix pair but is substantially different elsewhere. The PROSITE pattern PA2_HIS, specific to the first core helix, recognizes both families.","GO:0006644|phospholipid metabolic process;GO:0006954|inflammatory response;GO:0016042|lipid catabolic process;GO:0019835|cytolysis;GO:0036335|intestinal stem cell homeostasis;GO:0046337|phosphatidylethanolamine metabolic process;GO:0046470|phosphatidylcholine metabolic process;GO:0046473|phosphatidic acid metabolic process;GO:0050482|arachidonic acid secretion;GO:0050830|defense response to Gram-positive bacterium;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:1902563|regulation of neutrophil activation;","GO:0005615|extracellular space;GO:0005741|mitochondrial outer membrane;GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0030141|secretory granule;GO:0048471|perinuclear region of cytoplasm;","GO:0004623|phospholipase A2 activity;GO:0005509|calcium ion binding;GO:0005543|phospholipid binding;GO:0047498|calcium-dependent phospholipase A2 activity;","K01047","PLA2G, SPLA2; secretory phospholipase A2 [EC:3.1.1.4]"]
["ENSRNOG00000010872",903,58.09038568,4935,318.6127774,0.182322838,-2.455432811,0,0,"down","yes","Ckb","protein_coding","chr6:130729423-130732315:-","gi|56388799|gb|AAH87656.1|",1983,0,"Ckb protein, partial [Rattus norvegicus]","gi|401461783|ref|NM_012529.3|",1412,0,"Rattus norvegicus creatine kinase, brain (Ckb), mRNA","P07335",747,0,"Creatine kinase B-type","CAC3190",74.7,{"v":7e-14,"d":"7.00E-14"},"COG3869","pfam00217","ATP-gua_Ptrans","ATP:guanido phosphotransferase, C-terminal catalytic domain. The substrate binding site is located in the cleft between N and C-terminal domains, but most of the catalytic residues are found in the larger C-terminal domain.","GO:0007420|brain development;GO:0016310|phosphorylation;GO:0021549|cerebellum development;GO:0021762|substantia nigra development;GO:0030644|cellular chloride ion homeostasis;GO:0046314|phosphocreatine biosynthetic process;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005739|mitochondrion;GO:0005829|cytosol;GO:0030425|dendrite;GO:0043025|neuronal cell body;","GO:0004111|creatine kinase activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0016301|kinase activity;GO:0031625|ubiquitin protein ligase binding;","K00933","E2.7.3.2; creatine kinase [EC:2.7.3.2]"]
["ENSRNOG00000008937",4169,268.1935968,10755,694.3628006,0.386244189,-1.372414867,0,0,"down","yes","Csrp1","protein_coding","chr13:47167789-47179384:+","gi|8393206|ref|NP_058844.1|",786,{"v":1E-97,"d":"1.00E-97"},"cysteine and glycine-rich protein 1 [Rattus norvegicus]","gi|40538853|ref|NM_017148.2|",1437,0,"Rattus norvegicus cysteine and glycine-rich protein 1 (Csrp1), mRNA","P47875",307,{"v":4e-99,"d":"4.00E-99"},"Cysteine and glycine-rich protein 1",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.","GO:0007399|nervous system development;GO:0030036|actin cytoskeleton organization;GO:0045214|sarcomere organization;GO:0060537|muscle tissue development;GO:0070527|platelet aggregation;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0030018|Z disc;","GO:0008307|structural constituent of muscle;GO:0042805|actinin binding;GO:0046872|metal ion binding;","K09377","CSRP; cysteine and glycine-rich protein"]
["ENSRNOG00000013791",857,55.13118552,4794,309.5095552,0.178124341,-2.489043419,0,0,"down","yes","Enpp3","protein_coding","chr1:20563697-20635041:+","gi|162287180|ref|NP_062243.2|",4463,0,"ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [Rattus norvegicus]","gi|1699033|gb|U78788.1|RNU78788",2662,0,"Rattus norvegicus alkaline phosphodiesterase mRNA, complete cds","P97675",1721,0,"Ectonucleotide pyrophosphatase/phosphodiesterase family member 3","SPBC725.05c",202,{"v":2E-55,"d":"2.00E-55"},"COG1524","pfam01663","Phosphodiest","Type I phosphodiesterase / nucleotide pyrophosphatase. This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyse the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars. Also in this family is ATX an autotaxin, tumor cell motility-stimulating protein which exhibits type I phosphodiesterases activity. The alignment encompasses the active site. Also present with in this family is 60-kDa Ca2+-ATPase form F. odoratum.","GO:0002276|basophil activation involved in immune response;GO:0006220|pyrimidine nucleotide metabolic process;GO:0006796|phosphate-containing compound metabolic process;GO:0009143|nucleoside triphosphate catabolic process;GO:0033007|negative regulation of mast cell activation involved in immune response;GO:0046034|ATP metabolic process;GO:0050728|negative regulation of inflammatory response;GO:0051150|regulation of smooth muscle cell differentiation;GO:0070667|negative regulation of mast cell proliferation;GO:0090305|nucleic acid phosphodiester bond hydrolysis;","GO:0005576|extracellular region;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0048471|perinuclear region of cytoplasm;","GO:0003676|nucleic acid binding;GO:0004528|phosphodiesterase I activity;GO:0004551|nucleotide diphosphatase activity;GO:0005509|calcium ion binding;GO:0008270|zinc ion binding;GO:0035529|NADH pyrophosphatase activity;GO:0036218|dTTP diphosphatase activity;GO:0047429|nucleoside-triphosphate diphosphatase activity;","K01513","ENPP1_3, CD203; ectonucleotide pyrophosphatase/phosphodiesterase family member 1/3 [EC:3.1.4.1 3.6.1.9]"]
["ENSRNOG00000020525",718,46.18925462,4465,288.2687034,0.160229862,-2.641785046,0,0,"down","yes","Col5a3","protein_coding","chr8:19304571-19349853:-","gi|672061032|ref|XP_008764201.1|",1927,0,"PREDICTED: collagen alpha-3(V) chain isoform X1 [Rattus norvegicus]","gi|672061031|ref|XM_008765979.1|",6117,0,"PREDICTED: Rattus norvegicus collagen, type V, alpha 3 (Col5a3), transcript variant X1, mRNA","P25940",499,{"v":1e-144,"d":"1.00E-144"},"Collagen alpha-3(V) chain",".",".",".",".","pfam01410","COLFI","Fibrillar collagen C-terminal domain. Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1 alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.","GO:0007160|cell-matrix adhesion;GO:0030198|extracellular matrix organization;","GO:0005588|collagen type V trimer;GO:0005615|extracellular space;GO:0031012|extracellular matrix;GO:0062023|collagen-containing extracellular matrix;","GO:0005201|extracellular matrix structural constituent;GO:0008201|heparin binding;GO:0043394|proteoglycan binding;","K19721","COL5AS; collagen type V/XI/XXIV/XXVII, alpha"]
["ENSRNOG00000014610",405,26.05382746,3667,236.7483394,0.110048618,-3.183787072,0,0,"down","yes","Anpep","protein_coding","chr1:133767332-133785789:-","gi|564329002|ref|XP_006229469.1|",4869,0,"PREDICTED: aminopeptidase N isoform X1 [Rattus norvegicus]","gi|672037160|ref|XM_006229408.2|",3319,0,"PREDICTED: Rattus norvegicus alanyl (membrane) aminopeptidase (Anpep), transcript variant X2, mRNA","P15684",1877,0,"Aminopeptidase N","YHR047c",377,{"v":3e-113,"d":"3.00E-113"},"COG0308","pfam01433","Peptidase_M1","Peptidase family M1. Members of this family are aminopeptidases. The members differ widely in specificity, hydrolysing acidic, basic or neutral N-terminal residues. This family includes leukotriene-A4 hydrolase, this enzyme also has an aminopeptidase activity.","GO:0001525|angiogenesis;GO:0006508|proteolysis;GO:0007165|signal transduction;GO:0008217|regulation of blood pressure;GO:0030154|cell differentiation;GO:0035814|negative regulation of renal sodium excretion;GO:0043171|peptide catabolic process;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005793|endoplasmic reticulum-Golgi intermediate compartment;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0031526|brush border membrane;GO:0070062|extracellular exosome;","GO:0004177|aminopeptidase activity;GO:0008237|metallopeptidase activity;GO:0008270|zinc ion binding;GO:0042277|peptide binding;GO:0070006|metalloaminopeptidase activity;","K11140","ANPEP, CD13; aminopeptidase N [EC:3.4.11.2]"]
["ENSRNOG00000019445",7,0.450313067,3359,216.8632866,2.076484E-3,-8.911641778,0,0,"down","yes","Msln","protein_coding","chr10:14771961-14777643:-","gi|564371087|ref|XP_006246083.1|",3003,0,"PREDICTED: mesothelin isoform X1 [Rattus norvegicus]","gi|14389304|ref|NM_031658.1|",2063,0,"Rattus norvegicus mesothelin (Msln), mRNA","Q9ERA7",1163,0,"Mesothelin",".",".",".",".","pfam06060","Mesothelin","Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin). This family consists of several mammalian pre-pro-megakaryocyte potentiating factor precursor (MPF) or mesothelin proteins. Mesothelin is a glycosylphosphatidylinositol-linked glycoprotein highly expressed in mesothelial cells, mesotheliomas, and ovarian cancer, but the biological function of the protein is not known.","GO:0007160|cell-matrix adhesion;GO:0031016|pancreas development;","GO:0005615|extracellular space;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0031225|anchored component of membrane;","GO:0003674|molecular_function;","K20733","MSLN; mesothelin"]
["ENSRNOG00000058692",6,0.385982629,3330,214.9909927,1.795343E-3,-9.121524581,0,0,"down","yes","Slc26a4","protein_coding","chr6:48107588-48145703:-","gi|9506965|ref|NP_062087.1|",3275,0,"pendrin [Rattus norvegicus]","gi|672055748|ref|XM_008764576.1|",2853,0,"PREDICTED: Rattus norvegicus solute carrier family 26 (anion exchanger), member 4 (Slc26a4), transcript variant X1, mRNA","Q9R154",1266,0,"Pendrin","SPAC869.05c",152,{"v":5e-37,"d":"5.00E-37"},"COG0659","pfam00916","Sulfate_transp","Sulfate transporter family. Mutations in human SLC26A2 lead to several human diseases.","GO:0006885|regulation of pH;GO:0015698|inorganic anion transport;GO:0015701|bicarbonate transport;GO:0015705|iodide transport;GO:0019532|oxalate transport;GO:0032880|regulation of protein localization;GO:1902358|sulfate transmembrane transport;GO:1902476|chloride transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0016324|apical plasma membrane;GO:0031526|brush border membrane;GO:0070062|extracellular exosome;","GO:0008271|secondary active sulfate transmembrane transporter activity;GO:0015106|bicarbonate transmembrane transporter activity;GO:0015108|chloride transmembrane transporter activity;GO:0015111|iodide transmembrane transporter activity;GO:0015116|sulfate transmembrane transporter activity;GO:0015301|anion:anion antiporter activity;GO:0019531|oxalate transmembrane transporter activity;","K14702","SLC26A4, PDS; solute carrier family 26 (sodium-independent chloride/iodide transporter), member 4"]
["ENSRNOG00000019018",6728,432.8151881,14260,920.6521187,0.47011806,-1.08890499,0,0,"down","yes","Plat","protein_coding","chr16:69240585-69268223:-","gi|564389730|ref|XP_006253409.1|",2820,0,"PREDICTED: tissue-type plasminogen activator isoform X2 [Rattus norvegicus]","gi|672080489|ref|XM_006253347.2|",2441,0,"PREDICTED: Rattus norvegicus plasminogen activator, tissue (Plat), transcript variant X1, mRNA","P19637",1067,0,"Tissue-type plasminogen activator","mlr3307",109,{"v":8e-25,"d":"8.00E-25"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0001666|response to hypoxia;GO:0006508|proteolysis;GO:0014909|smooth muscle cell migration;GO:0031639|plasminogen activation;GO:0035249|synaptic transmission, glutamatergic;GO:0042060|wound healing;GO:0045861|negative regulation of proteolysis;GO:0048008|platelet-derived growth factor receptor signaling pathway;GO:0048167|regulation of synaptic plasticity;GO:0051591|response to cAMP;GO:0060279|positive regulation of ovulation;GO:0060468|prevention of polyspermy;GO:0070542|response to fatty acid;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0071373|cellular response to luteinizing hormone stimulus;GO:0071549|cellular response to dexamethasone stimulus;GO:0099183|trans-synaptic signaling by BDNF, modulating synaptic transmission;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0009986|cell surface;GO:0030141|secretory granule;GO:0045177|apical part of cell;GO:0045202|synapse;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098794|postsynapse;GO:0098978|glutamatergic synapse;GO:0098992|neuronal dense core vesicle;GO:0099544|perisynaptic space;","GO:0003674|molecular_function;GO:0004252|serine-type endopeptidase activity;GO:0005102|signaling receptor binding;GO:0051219|phosphoprotein binding;","K01343","PLAT; tissue plasminogen activator [EC:3.4.21.68]"]
["ENSRNOG00000006604",529,34.0308018,3745,241.7841644,0.140748679,-2.828806711,0,0,"down","yes","Thy1","protein_coding","chr8:44389513-44394659:+","gi|149041432|gb|EDL95273.1|",870,{"v":2e-105,"d":"2.00E-105"},"thymus cell antigen 1, theta, isoform CRA_b [Rattus norvegicus]","gi|298231254|ref|NM_012673.2|",863,0,"Rattus norvegicus Thy-1 cell surface antigen (Thy1), mRNA","P01830",283,{"v":6e-87,"d":"6.00E-87"},"Thy-1 membrane glycoprotein",".",".",".",".","pfam00047","ig","Immunoglobulin domain. Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions. The Pfam alignments do not include the first and last strand of the immunoglobulin-like domain.","GO:0001525|angiogenesis;GO:0001952|regulation of cell-matrix adhesion;GO:0002693|positive regulation of cellular extravasation;GO:0006469|negative regulation of protein kinase activity;GO:0007010|cytoskeleton organization;GO:0007229|integrin-mediated signaling pathway;GO:0007267|cell-cell signaling;GO:0030336|negative regulation of cell migration;GO:0034116|positive regulation of heterotypic cell-cell adhesion;GO:0043066|negative regulation of apoptotic process;GO:0043113|receptor clustering;GO:0043547|positive regulation of GTPase activity;GO:0045576|mast cell activation;GO:0046549|retinal cone cell development;GO:0046777|protein autophosphorylation;GO:0048041|focal adhesion assembly;GO:0048147|negative regulation of fibroblast proliferation;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050771|negative regulation of axonogenesis;GO:0050852|T cell receptor signaling pathway;GO:0050860|negative regulation of T cell receptor signaling pathway;GO:0050870|positive regulation of T cell activation;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;GO:0051894|positive regulation of focal adhesion assembly;GO:0061099|negative regulation of protein tyrosine kinase activity;GO:0070571|negative regulation of neuron projection regeneration;GO:0098609|cell-cell adhesion;GO:2000298|regulation of Rho-dependent protein serine/threonine kinase activity;","GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016324|apical plasma membrane;GO:0030425|dendrite;GO:0030426|growth cone;GO:0030673|axolemma;GO:0031362|anchored component of external side of plasma membrane;GO:0032590|dendrite membrane;GO:0032809|neuronal cell body membrane;GO:0045121|membrane raft;GO:0046658|anchored component of plasma membrane;","GO:0005096|GTPase activator activity;GO:0005178|integrin binding;GO:0005515|protein binding;GO:0019899|enzyme binding;GO:0019901|protein kinase binding;GO:0034235|GPI anchor binding;","K06514","THY1, CD90; Thy-1 cell surface antigen"]
["ENSRNOG00000004405",4,0.257321753,3380,218.2190856,0.00117919,-9.727988151,0,0,"down","yes","Pigr","protein_coding","chr13:42298914-42326875:+","gi|149058686|gb|EDM09843.1|",3845,0,"polymeric immunoglobulin receptor [Rattus norvegicus]","gi|501354878|ref|NM_012723.4|",3890,0,"Rattus norvegicus polymeric immunoglobulin receptor (Pigr), mRNA","P15083",1459,0,"Polymeric immunoglobulin receptor",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0001580|detection of chemical stimulus involved in sensory perception of bitter taste;GO:0001895|retina homeostasis;GO:0002415|immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor;GO:0007173|epidermal growth factor receptor signaling pathway;GO:0038093|Fc receptor signaling pathway;GO:0043113|receptor clustering;","GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030133|transport vesicle;GO:0043235|receptor complex;GO:0055038|recycling endosome membrane;GO:0071751|secretory IgA immunoglobulin complex;","GO:0001792|polymeric immunoglobulin receptor activity;GO:0004888|transmembrane signaling receptor activity;GO:0005154|epidermal growth factor receptor binding;","K13073","PIGR; polymeric immunoglobulin receptor"]
["ENSRNOG00000014231",56,3.602504538,2349,151.6558083,0.023754478,-5.395656695,0,0,"down","yes","Pnoc","protein_coding","chr15:39624641-39651867:-","gi|6981378|ref|NP_037139.1|",765,{"v":3E-98,"d":"3.00E-98"},"prepronociceptin precursor [Rattus norvegicus]","gi|672078247|ref|XM_006252199.2|",1015,0,"PREDICTED: Rattus norvegicus prepronociceptin (Pnoc), transcript variant X2, mRNA","Q62923",299,{"v":9e-100,"d":"9.00E-100"},"Prepronociceptin",".",".",".",".","pfam01160","Opiods_neuropep","Vertebrate endogenous opioids neuropeptide.","GO:0007218|neuropeptide signaling pathway;GO:0007268|chemical synaptic transmission;GO:0007565|female pregnancy;GO:0007600|sensory perception;","GO:0005576|extracellular region;GO:0005886|plasma membrane;GO:0030425|dendrite;GO:0043025|neuronal cell body;GO:0043679|axon terminus;","GO:0001515|opioid peptide activity;GO:0031628|opioid receptor binding;","K25696","PNOC; prepronociceptin"]
["ENSRNOG00000024115",101,6.497374257,2449,158.1119943,0.041093494,-4.604946195,0,0,"down","yes","C6","protein_coding","chr2:53851985-53921275:+","gi|28570180|ref|NP_788263.1|",4944,0,"complement component C6 precursor [Rattus norvegicus]","gi|402743755|ref|NM_176074.3|",2985,0,"Rattus norvegicus complement component 6 (C6), mRNA","Q811M5",1909,0,"Complement component C6",".",".",".",".","pfam01823","MACPF","MAC/Perforin domain. The membrane-attack complex (MAC) of the complement system forms transmembrane channels. These channels disrupt the phospholipid bilayer of target cells, leading to cell lysis and death. A number of proteins participate in the assembly of the MAC. Freshly activated C5b binds to C6 to form a C5b-6 complex, then to C7 forming the C5b-7 complex. The C5b-7 complex binds to C8, which is composed of three chains (alpha, beta, and gamma), thus forming the C5b-8 complex. C5b-8 subsequently binds to C9 and acts as a catalyst in the polymerization of C9. Active MAC has a subunit composition of C5b-C6-C7-C8-C9{n}. Perforin is a protein found in cytolytic T-cell and killer cells. In the presence of calcium, perforin polymerizes into transmembrane tubules and is capable of lysing, non-specifically, a variety of target cells. There are a number of regions of similarity in the sequences of complement components C6, C7, C8-alpha, C8-beta, C9 and perforin. The X-ray crystal structure of a MACPF domain reveals that it shares a common fold with bacterial cholesterol dependent cytolysins (pfam01289) such as perfringolysin O. Three key pieces of evidence suggests that MACPF domains and CDCs are homologous: Functional similarity (pore formation), conservation of three glycine residues at a hinge in both families and conservation of a complex core fold.","GO:0001701|in utero embryonic development;GO:0001970|positive regulation of activation of membrane attack complex;GO:0006958|complement activation, classical pathway;GO:0019835|cytolysis;GO:0043065|positive regulation of apoptotic process;GO:0045087|innate immune response;GO:0045766|positive regulation of angiogenesis;GO:0045917|positive regulation of complement activation;","GO:0005576|extracellular region;GO:0005579|membrane attack complex;GO:0005615|extracellular space;","GO:0003674|molecular_function;","K03995","C6; complement component 6"]
["ENSRNOG00000018461",2576,165.7152088,7501,484.2785093,0.342189888,-1.547130968,0,0,"down","yes","Pdgfrb","protein_coding","chr18:54499964-54538843:+","gi|29789275|ref|NP_113713.1|",5463,0,"platelet-derived growth factor receptor beta precursor [Rattus norvegicus]","gi|672083246|ref|XM_006254789.2|",5395,0,"PREDICTED: Rattus norvegicus platelet derived growth factor receptor, beta polypeptide (Pdgfrb), transcript variant X1, mRNA","Q05030",2108,0,"Platelet-derived growth factor receptor beta",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001525|angiogenesis;GO:0001568|blood vessel development;GO:0001701|in utero embryonic development;GO:0001822|kidney development;GO:0001894|tissue homeostasis;GO:0006024|glycosaminoglycan biosynthetic process;GO:0006807|nitrogen compound metabolic process;GO:0007165|signal transduction;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007275|multicellular organism development;GO:0007568|aging;GO:0008284|positive regulation of cell proliferation;GO:0008584|male gonad development;GO:0009636|response to toxic substance;GO:0010863|positive regulation of phospholipase C activity;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0014070|response to organic cyclic compound;GO:0014911|positive regulation of smooth muscle cell migration;GO:0016477|cell migration;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0030325|adrenal gland development;GO:0030335|positive regulation of cell migration;GO:0032355|response to estradiol;GO:0032516|positive regulation of phosphoprotein phosphatase activity;GO:0032526|response to retinoic acid;GO:0032956|regulation of actin cytoskeleton organization;GO:0032967|positive regulation of collagen biosynthetic process;GO:0033674|positive regulation of kinase activity;GO:0033993|response to lipid;GO:0034405|response to fluid shear stress;GO:0035025|positive regulation of Rho protein signal transduction;GO:0035441|cell migration involved in vasculogenesis;GO:0035556|intracellular signal transduction;GO:0035789|metanephric mesenchymal cell migration;GO:0035791|platelet-derived growth factor receptor-beta signaling pathway;GO:0035793|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway;GO:0035909|aorta morphogenesis;GO:0036120|cellular response to platelet-derived growth factor stimulus;GO:0038091|positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway;GO:0042060|wound healing;GO:0042542|response to hydrogen peroxide;GO:0043065|positive regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0043406|positive regulation of MAP kinase activity;GO:0043552|positive regulation of phosphatidylinositol 3-kinase activity;GO:0043627|response to estrogen;GO:0045840|positive regulation of mitotic nuclear division;GO:0046488|phosphatidylinositol metabolic process;GO:0046777|protein autophosphorylation;GO:0048008|platelet-derived growth factor receptor signaling pathway;GO:0048015|phosphatidylinositol-mediated signaling;GO:0048146|positive regulation of fibroblast proliferation;GO:0048568|embryonic organ development;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0048705|skeletal system morphogenesis;GO:0048745|smooth muscle tissue development;GO:0048839|inner ear development;GO:0050730|regulation of peptidyl-tyrosine phosphorylation;GO:0050921|positive regulation of chemotaxis;GO:0055003|cardiac myofibril assembly;GO:0055093|response to hyperoxia;GO:0060326|cell chemotaxis;GO:0060437|lung growth;GO:0060981|cell migration involved in coronary angiogenesis;GO:0061298|retina vasculature development in camera-type eye;GO:0070301|cellular response to hydrogen peroxide;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071670|smooth muscle cell chemotaxis;GO:0072075|metanephric mesenchyme development;GO:0072223|metanephric glomerular mesangium development;GO:0072262|metanephric glomerular mesangial cell proliferation involved in metanephros development;GO:0072275|metanephric glomerulus morphogenesis;GO:0072277|metanephric glomerular capillary formation;GO:0072278|metanephric comma-shaped body morphogenesis;GO:0072284|metanephric S-shaped body morphogenesis;GO:0090280|positive regulation of calcium ion import;GO:0097178|ruffle assembly;GO:0106096|response to ceramide;GO:2000379|positive regulation of reactive oxygen species metabolic process;GO:2000491|positive regulation of hepatic stellate cell activation;GO:2000573|positive regulation of DNA biosynthetic process;","GO:0001726|ruffle;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0016324|apical plasma membrane;GO:0031226|intrinsic component of plasma membrane;GO:0031410|cytoplasmic vesicle;GO:0043202|lysosomal lumen;GO:0043231|intracellular membrane-bounded organelle;GO:0043235|receptor complex;","GO:0004672|protein kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0005017|platelet-derived growth factor-activated receptor activity;GO:0005019|platelet-derived growth factor beta-receptor activity;GO:0005102|signaling receptor binding;GO:0005161|platelet-derived growth factor receptor binding;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0016301|kinase activity;GO:0019838|growth factor binding;GO:0019899|enzyme binding;GO:0019901|protein kinase binding;GO:0038085|vascular endothelial growth factor binding;GO:0043548|phosphatidylinositol 3-kinase binding;GO:0048407|platelet-derived growth factor binding;","K05089","PDGFRB, CD140B; platelet-derived growth factor receptor beta [EC:2.7.10.1]"]
["ENSRNOG00000029042",1441,92.70016142,5471,353.2179342,0.262444662,-1.92991484,0,0,"down","yes","Mt-nd6","protein_coding","chrMT:13543-14061:-","gi|110189726|ref|YP_665640.1|",727,{"v":3e-95,"d":"3.00E-95"},"NADH dehydrogenase subunit 6 [Rattus norvegicus]","gi|755572967|gb|KP244683.1|",519,0,"Rattus norvegicus isolate 115 mitochondrion, complete genome","P03926",284,{"v":1e-96,"d":"1.00E-96"},"NADH-ubiquinone oxidoreductase chain 6",".",".",".",".","pfam00499","Oxidored_q3","NADH-ubiquinone/plastoquinone oxidoreductase chain 6.","GO:0006120|mitochondrial electron transport, NADH to ubiquinone;GO:0032981|mitochondrial respiratory chain complex I assembly;GO:0035094|response to nicotine;GO:0042220|response to cocaine;GO:0042542|response to hydrogen peroxide;","GO:0005575|cellular_component;GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0016021|integral component of membrane;GO:0070469|respiratory chain;","GO:0003674|molecular_function;GO:0008137|NADH dehydrogenase (ubiquinone) activity;","K03884","ND6; NADH-ubiquinone oxidoreductase chain 6 [EC:7.1.1.2]"]
["ENSRNOG00000003899",163,10.48586142,2544,164.245371,0.06384266,-3.96933542,0,0,"down","yes","Krt15","protein_coding","chr10:85066802-85171799:-","gi|56912233|ref|NP_001008751.1|",2017,0,"keratin, type I cytoskeletal 14 [Rattus norvegicus]","gi|56912232|ref|NM_001008751.1|",1458,0,"Rattus norvegicus keratin 14, type I (Krt14), mRNA","Q6IFV1",781,0,"Keratin, type I cytoskeletal 14",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0007568|aging;GO:0010043|response to zinc ion;GO:0010212|response to ionizing radiation;GO:0030855|epithelial cell differentiation;GO:0042633|hair cycle;GO:0045110|intermediate filament bundle assembly;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005882|intermediate filament;GO:0045095|keratin filament;GO:0045178|basal part of cell;GO:0071944|cell periphery;","GO:0003674|molecular_function;GO:0005198|structural molecule activity;GO:1990254|keratin filament binding;","K07604","KRT1; type I keratin, acidic"]
["ENSRNOG00000060614",2344,150.7905471,6976,450.383533,0.334804752,-1.57860809,0,0,"down","yes","Pxdn","protein_coding","chr6:46580761-46658345:+","gi|404247440|ref|NP_001258190.1|",7826,0,"peroxidasin homolog precursor [Rattus norvegicus]","gi|404247439|ref|NM_001271261.1|",6563,0,"Rattus norvegicus peroxidasin homolog (Drosophila) (Pxdn), mRNA","Q3UQ28",2975,0,"Peroxidasin homolog",".",".",".",".","pfam03098","An_peroxidase","Animal haem peroxidase.","GO:0006979|response to oxidative stress;GO:0030198|extracellular matrix organization;GO:0030199|collagen fibril organization;GO:0042744|hydrogen peroxide catabolic process;GO:0098869|cellular oxidant detoxification;","GO:0005615|extracellular space;GO:0005783|endoplasmic reticulum;GO:0062023|collagen-containing extracellular matrix;","GO:0004601|peroxidase activity;GO:0005201|extracellular matrix structural constituent;GO:0019806|bromide peroxidase activity;GO:0020037|heme binding;","K19511","PXDN, VPO1; peroxidase [EC:1.11.1.7]"]
["ENSRNOG00000012216",1173,75.45960399,4795,309.574117,0.243752949,-2.036508421,0,0,"down","yes","Tgfbi","protein_coding","chr17:7955603-7985240:-","gi|281332117|ref|NP_446254.1|",3355,0,"transforming growth factor-beta-induced protein ig-h3 precursor [Rattus norvegicus]","gi|281332116|ref|NM_053802.1|",2207,0,"Rattus norvegicus transforming growth factor, beta induced (Tgfbi), mRNA","P82198",1256,0,"Transforming growth factor-beta-induced protein ig-h3","MA1996",89,{"v":5e-18,"d":"5.00E-18"},"COG2335","pfam02469","Fasciclin","Fasciclin domain. This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.","GO:0001525|angiogenesis;GO:0002062|chondrocyte differentiation;GO:0007155|cell adhesion;GO:0008283|cell proliferation;GO:0030198|extracellular matrix organization;","GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0005802|trans-Golgi network;GO:0031012|extracellular matrix;","GO:0003674|molecular_function;GO:0005178|integrin binding;GO:0005518|collagen binding;GO:0042802|identical protein binding;GO:0050839|cell adhesion molecule binding;GO:0050840|extracellular matrix binding;","K19519","TGFBI, BIGH3; transforming growth factor-beta-induced protein"]
["ENSRNOG00000029945",2,0.128660876,3491,225.3854521,0.000570848,-10.77460526,0,0,"down","yes","Cuzd1","protein_coding","chr1:186089423-186102546:-","gi|149061263|gb|EDM11686.1|",3272,0,"CUB and zona pellucida-like domains 1 [Rattus norvegicus]","gi|16758921|ref|NM_054005.1|",2237,0,"Rattus norvegicus CUB and zona pellucida-like domains 1 (Cuzd1), mRNA","Q9QZT0",1261,0,"CUB and zona pellucida-like domain-containing protein 1",".",".",".",".","pfam00100","Zona_pellucida","Zona pellucida-like domain.","GO:0007565|female pregnancy;GO:0009755|hormone-mediated signaling pathway;GO:0032023|trypsinogen activation;","GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0042588|zymogen granule;GO:0042589|zymogen granule membrane;",".","K24793","CUZD1; CUB and zona pellucida-like domain-containing protein 1"]
["ENSRNOG00000015078",5071,326.219652,11098,716.5075185,0.455291317,-1.135138148,0,0,"down","yes","Ifitm3","protein_coding","chr1:196111043-196112203:-","gi|209915621|ref|NP_001129596.1|",615,{"v":5e-78,"d":"5.00E-78"},"interferon-induced transmembrane protein 3 [Rattus norvegicus]","gi|298906391|emb|FQ221958.1|",618,0,"Rattus norvegicus TL0ADA2YK02 mRNA sequence","P26376",241,{"v":2E-79,"d":"2.00E-79"},"Interferon-induced transmembrane protein 3",".",".",".",".","pfam04505","Dispanin","Interferon-induced transmembrane protein. This family includes the human leukocyte antigen CD225, which is an interferon inducible transmembrane protein, and is associated with interferon induced cell growth suppression.","GO:0006898|receptor-mediated endocytosis;GO:0007507|heart development;GO:0008285|negative regulation of cell proliferation;GO:0009615|response to virus;GO:0032897|negative regulation of viral transcription;GO:0034341|response to interferon-gamma;GO:0035455|response to interferon-alpha;GO:0035456|response to interferon-beta;GO:0045071|negative regulation of viral genome replication;GO:0046597|negative regulation of viral entry into host cell;GO:0051607|defense response to virus;GO:0055007|cardiac muscle cell differentiation;GO:0060337|type I interferon signaling pathway;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005765|lysosomal membrane;GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0031410|cytoplasmic vesicle;GO:0031901|early endosome membrane;GO:0031902|late endosome membrane;GO:0032991|protein-containing complex;GO:0045177|apical part of cell;GO:0048471|perinuclear region of cytoplasm;","GO:0003674|molecular_function;","K06566","IFITM; interferon induced transmembrane protein"]
["ENSRNOG00000016687",181,11.64380931,2490,160.7590305,0.072430204,-3.787264759,0,0,"down","yes","Ssc5d","protein_coding","chr1:68891949-68909743:-","gi|197386139|ref|NP_001128017.1|",5661,0,"soluble scavenger receptor cysteine-rich domain-containing protein SSC5D precursor [Rattus norvegicus]","gi|197386138|ref|NM_001134545.1|",4495,0,"Rattus norvegicus scavenger receptor cysteine rich family, 5 domains (Ssc5d), mRNA","Q8BV57",1753,0,"Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D",".",".",".",".","pfam00530","SRCR","Scavenger receptor cysteine-rich domain. These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.","GO:0006897|endocytosis;GO:0006952|defense response;GO:0032677|regulation of interleukin-8 production;GO:0032717|negative regulation of interleukin-8 production;GO:0042494|detection of bacterial lipoprotein;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;","GO:0005615|extracellular space;GO:0016020|membrane;GO:0031012|extracellular matrix;GO:0062023|collagen-containing extracellular matrix;","GO:0001968|fibronectin binding;GO:0005044|scavenger receptor activity;GO:0043236|laminin binding;GO:0050840|extracellular matrix binding;",".","."]
["ENSRNOG00000033389",180,11.57947887,2482,160.2425357,0.072262204,-3.790614923,0,0,"down","yes","Susd2","protein_coding","chr20:13017477-13024903:+","gi|564397585|ref|XP_006256400.1|",4431,0,"PREDICTED: sushi domain-containing protein 2 isoform X1 [Rattus norvegicus]","gi|672086156|ref|XM_006256338.2|",3205,0,"PREDICTED: Rattus norvegicus sushi domain containing 2 (Susd2), transcript variant X1, mRNA","Q9DBX3",1532,0,"Sushi domain-containing protein 2",".",".",".",".","pfam03782","AMOP","AMOP domain. This domain may have a role in cell adhesion. It is called the AMOP domain after Adhesion associated domain in MUC4 and Other Proteins. This domain is extracellular and contains a number of cysteines that probably form disulphide bridges.","GO:0051782|negative regulation of cell division;GO:1902807|negative regulation of cell cycle G1/S phase transition;","GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;",".","K23820","SUSD2; sushi domain-containing protein 2"]
["ENSRNOG00000024159",658,42.32942833,3637,234.8114836,0.180269839,-2.471770056,0,0,"down","yes","Fcer1g","protein_coding","chr13:83649449-83671443:-","gi|58865384|ref|NP_001011907.1|",2498,0,"NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial precursor [Rattus norvegicus]","gi|564381782|ref|XM_003751277.2|",1602,0,"PREDICTED: Rattus norvegicus NADH dehydrogenase (ubiquinone) Fe-S protein 2 (Ndufs2), transcript variant X1, mRNA","Q641Y2",966,0,"NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial","RP354",570,0,"COG0649","pfam00346","Complex1_49kDa","Respiratory-chain NADH dehydrogenase, 49 Kd subunit.","GO:0001798|positive regulation of type IIa hypersensitivity;GO:0001805|positive regulation of type III hypersensitivity;GO:0001812|positive regulation of type I hypersensitivity;GO:0002283|neutrophil activation involved in immune response;GO:0002292|T cell differentiation involved in immune response;GO:0002431|Fc receptor mediated stimulatory signaling pathway;GO:0002554|serotonin secretion by platelet;GO:0006911|phagocytosis, engulfment;GO:0007165|signal transduction;GO:0007166|cell surface receptor signaling pathway;GO:0007229|integrin-mediated signaling pathway;GO:0010543|regulation of platelet activation;GO:0016064|immunoglobulin mediated immune response;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030316|osteoclast differentiation;GO:0030593|neutrophil chemotaxis;GO:0031623|receptor internalization;GO:0032733|positive regulation of interleukin-10 production;GO:0032753|positive regulation of interleukin-4 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032765|positive regulation of mast cell cytokine production;GO:0033026|negative regulation of mast cell apoptotic process;GO:0038094|Fc-gamma receptor signaling pathway;GO:0038095|Fc-epsilon receptor signaling pathway;GO:0038156|interleukin-3-mediated signaling pathway;GO:0042590|antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:0042742|defense response to bacterium;GO:0043306|positive regulation of mast cell degranulation;GO:0045087|innate immune response;GO:0045576|mast cell activation;GO:0050766|positive regulation of phagocytosis;GO:0050776|regulation of immune response;GO:0050778|positive regulation of immune response;GO:0071404|cellular response to low-density lipoprotein particle stimulus;GO:0072659|protein localization to plasma membrane;GO:2000010|positive regulation of protein localization to cell surface;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0032998|Fc-epsilon receptor I complex;","GO:0005515|protein binding;GO:0019767|IgE receptor activity;GO:0019863|IgE binding;GO:0019864|IgG binding;GO:0042802|identical protein binding;","K07983","FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma"]
["ENSRNOG00000018233",4336,278.93678,9873,637.4192404,0.437603327,-1.19230439,0,0,"down","yes","Gas6","protein_coding","chr16:76045426-76075904:+","gi|48427855|sp|Q63772.1|GAS6_RAT",3345,0,"RecName: Full=Growth arrest-specific protein 6; Short=GAS-6; AltName: Full=AXL receptor tyrosine kinase ligand; AltName: Full=Growth-potentiating factor; Short=GPF; Flags: Precursor","gi|145279185|ref|NM_057100.2|",2535,0,"Rattus norvegicus growth arrest specific 6 (Gas6), mRNA","Q63772",1292,0,"Growth arrest-specific protein 6",".",".",".",".","pfam02210","Laminin_G_2","Laminin G domain. This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.","GO:0001764|neuron migration;GO:0001934|positive regulation of protein phosphorylation;GO:0001961|positive regulation of cytokine-mediated signaling pathway;GO:0003104|positive regulation of glomerular filtration;GO:0006468|protein phosphorylation;GO:0006909|phagocytosis;GO:0006915|apoptotic process;GO:0007165|signal transduction;GO:0007167|enzyme linked receptor protein signaling pathway;GO:0007596|blood coagulation;GO:0009267|cellular response to starvation;GO:0010628|positive regulation of gene expression;GO:0010804|negative regulation of tumor necrosis factor-mediated signaling pathway;GO:0018105|peptidyl-serine phosphorylation;GO:0019064|fusion of virus membrane with host plasma membrane;GO:0019079|viral genome replication;GO:0031100|animal organ regeneration;GO:0031589|cell-substrate adhesion;GO:0032008|positive regulation of TOR signaling;GO:0032148|activation of protein kinase B activity;GO:0032689|negative regulation of interferon-gamma production;GO:0032692|negative regulation of interleukin-1 production;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032825|positive regulation of natural killer cell differentiation;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0035457|cellular response to interferon-alpha;GO:0035754|B cell chemotaxis;GO:0040008|regulation of growth;GO:0042246|tissue regeneration;GO:0043066|negative regulation of apoptotic process;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043277|apoptotic cell clearance;GO:0043433|negative regulation of DNA-binding transcription factor activity;GO:0043491|protein kinase B signaling;GO:0045860|positive regulation of protein kinase activity;GO:0045892|negative regulation of transcription, DNA-templated;GO:0046718|viral entry into host cell;GO:0046813|receptor-mediated virion attachment to host cell;GO:0046827|positive regulation of protein export from nucleus;GO:0048146|positive regulation of fibroblast proliferation;GO:0048771|tissue remodeling;GO:0050766|positive regulation of phagocytosis;GO:0051897|positive regulation of protein kinase B signaling;GO:0061098|positive regulation of protein tyrosine kinase activity;GO:0070168|negative regulation of biomineral tissue development;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070588|calcium ion transmembrane transport;GO:0071307|cellular response to vitamin K;GO:0071333|cellular response to glucose stimulus;GO:0071363|cellular response to growth factor stimulus;GO:0071466|cellular response to xenobiotic stimulus;GO:0072659|protein localization to plasma membrane;GO:0085029|extracellular matrix assembly;GO:0097028|dendritic cell differentiation;GO:0097241|hematopoietic stem cell migration to bone marrow;GO:1900142|negative regulation of oligodendrocyte apoptotic process;GO:2000270|negative regulation of fibroblast apoptotic process;GO:2000352|negative regulation of endothelial cell apoptotic process;GO:2000510|positive regulation of dendritic cell chemotaxis;GO:2000533|negative regulation of renal albumin absorption;GO:2000669|negative regulation of dendritic cell apoptotic process;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;","GO:0001786|phosphatidylserine binding;GO:0005102|signaling receptor binding;GO:0005509|calcium ion binding;GO:0008083|growth factor activity;GO:0030296|protein tyrosine kinase activator activity;GO:0030674|protein binding, bridging;GO:0030971|receptor tyrosine kinase binding;GO:0043027|cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0048018|receptor ligand activity;","K05464","GAS6; growth arrest-specific 6"]
["ENSRNOG00000012807",1333,85.7524741,4923,317.8380351,0.269799283,-1.890041579,0,0,"down","yes","C1qa","protein_coding","chr5:149133636-149136534:-","gi|56606082|ref|NP_001008515.1|",1272,{"v":3e-169,"d":"3.00E-169"},"complement C1q subcomponent subunit A precursor [Rattus norvegicus]","gi|56606081|ref|NM_001008515.1|",975,0,"Rattus norvegicus complement component 1, q subcomponent, A chain (C1qa), mRNA","P31720",494,{"v":1e-170,"d":"1.00E-170"},"Complement C1q subcomponent subunit A",".",".",".",".","pfam00386","C1q","C1q domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.","GO:0001774|microglial cell activation;GO:0006958|complement activation, classical pathway;GO:0007568|aging;GO:0010039|response to iron ion;GO:0016322|neuron remodeling;GO:0045087|innate immune response;GO:0048143|astrocyte activation;GO:0050808|synapse organization;GO:0098883|synapse pruning;GO:0150062|complement-mediated synapse pruning;GO:0150064|vertebrate eye-specific patterning;GO:1901216|positive regulation of neuron death;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005581|collagen trimer;GO:0045202|synapse;GO:0098794|postsynapse;","GO:0003674|molecular_function;","K03986","C1QA; complement C1q subcomponent subunit A"]
["ENSRNOG00000014574",687,44.19501103,3574,230.7440864,0.191532584,-2.38433825,0,0,"down","yes","Entpd1","protein_coding","chr1:239425430-239552317:+","gi|815891318|ref|NP_072109.2|",2716,0,"ectonucleoside triphosphate diphosphohydrolase 1 [Rattus norvegicus]","gi|111038159|gb|AC112047.5|",5482,0,"Rattus norvegicus BAC CH230-32C14 () complete sequence","P97687",1040,0,"Ectonucleoside triphosphate diphosphohydrolase 1","YER005w",159,{"v":7E-39,"d":"7.00E-39"},"COG5371","pfam01150","GDA1_CD39","GDA1/CD39 (nucleoside phosphatase) family.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0009134|nucleoside diphosphate catabolic process;GO:0009181|purine ribonucleoside diphosphate catabolic process;GO:0010238|response to proline;GO:0010332|response to gamma radiation;GO:0010996|response to auditory stimulus;GO:0030168|platelet activation;GO:0031000|response to caffeine;GO:0032496|response to lipopolysaccharide;GO:0033198|response to ATP;GO:0033602|negative regulation of dopamine secretion;GO:0035456|response to interferon-beta;GO:0035457|cellular response to interferon-alpha;GO:0043278|response to morphine;GO:0046032|ADP catabolic process;GO:0071222|cellular response to lipopolysaccharide;GO:0071275|cellular response to aluminum ion;GO:0071356|cellular response to tumor necrosis factor;GO:1903576|response to L-arginine;GO:2001170|negative regulation of ATP biosynthetic process;","GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0008021|synaptic vesicle;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0097060|synaptic membrane;","GO:0004382|guanosine-diphosphatase activity;GO:0005524|ATP binding;GO:0016787|hydrolase activity;GO:0016887|ATPase activity;GO:0017110|nucleoside-diphosphatase activity;GO:0017111|nucleoside-triphosphatase activity;GO:0042802|identical protein binding;GO:0043262|adenosine-diphosphatase activity;GO:0045134|uridine-diphosphatase activity;GO:0102485|dATP phosphohydrolase activity;GO:0102486|dCTP phosphohydrolase activity;GO:0102487|dUTP phosphohydrolase activity;GO:0102488|dTTP phosphohydrolase activity;GO:0102489|GTP phosphohydrolase activity;GO:0102490|8-oxo-dGTP phosphohydrolase activity;GO:0102491|dGTP phosphohydrolase activity;","K01510","ENTPD1_3_8, CD39; apyrase [EC:3.6.1.5]"]
["ENSRNOG00000015902",37,2.380226213,1958,126.4121212,0.018829098,-5.730892303,0,0,"down","yes","Cpxm2","protein_coding","chr1:186836797-186947220:-","gi|157821069|ref|NP_001099776.1|",3545,0,"inactive carboxypeptidase-like protein X2 precursor [Rattus norvegicus]","gi|157821068|ref|NM_001106306.1|",3498,0,"Rattus norvegicus carboxypeptidase X (M14 family), member 2 (Cpxm2), mRNA","Q9D2L5",1317,0,"Inactive carboxypeptidase-like protein X2",".",".",".",".","pfam00246","Peptidase_M14","Zinc carboxypeptidase.","GO:0006518|peptide metabolic process;GO:0016485|protein processing;","GO:0005615|extracellular space;","GO:0004181|metallocarboxypeptidase activity;GO:0008270|zinc ion binding;","K08639","CPXM2; carboxypeptidase X2"]
["ENSRNOG00000010319",365,23.48060994,2811,181.4833875,0.129381594,-2.950295704,0,0,"down","yes","Lcp1","protein_coding","chr15:50488149-50544680:+","gi|564387027|ref|XP_006252380.1|",3378,0,"PREDICTED: plastin-2 isoform X2 [Rattus norvegicus]","gi|672078709|ref|XM_006252320.2|",3387,0,"PREDICTED: Rattus norvegicus lymphocyte cytosolic protein 1 (Lcp1), transcript variant X3, mRNA","Q61233",1286,0,"Plastin-2","SPBC1778.06c",441,{"v":9e-139,"d":"9.00E-139"},"COG5069","pfam00307","CH","Calponin homology (CH) domain. The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.","GO:0002286|T cell activation involved in immune response;GO:0010737|protein kinase A signaling;GO:0016477|cell migration;GO:0022617|extracellular matrix disassembly;GO:0031100|animal organ regeneration;GO:0033157|regulation of intracellular protein transport;GO:0051017|actin filament bundle assembly;GO:0051639|actin filament network formation;GO:0071803|positive regulation of podosome assembly;","GO:0001725|stress fiber;GO:0001726|ruffle;GO:0001891|phagocytic cup;GO:0002102|podosome;GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0005925|focal adhesion;GO:0015629|actin cytoskeleton;GO:0030175|filopodium;GO:0032432|actin filament bundle;GO:0048471|perinuclear region of cytoplasm;","GO:0003674|molecular_function;GO:0005178|integrin binding;GO:0005509|calcium ion binding;GO:0042802|identical protein binding;GO:0051015|actin filament binding;GO:0051020|GTPase binding;","K17276","LCP1, PLS2; plastin-2"]
["ENSRNOG00000007338",243,15.63229648,2492,160.8881543,0.097162507,-3.363456469,0,0,"down","yes","Fbln2","protein_coding","chr4:123704373-123763948:+","gi|564304062|ref|XP_006225052.1|",5789,0,"PREDICTED: fibulin-2 isoform X1 [Rattus norvegicus]","gi|672018554|ref|XM_006224990.2|",4430,0,"PREDICTED: Rattus norvegicus fibulin 2 (Fbln2), transcript variant X1, mRNA","P37889",2177,0,"Fibulin-2",".",".",".",".","pfam07645","EGF_CA","Calcium-binding EGF domain.","GO:0010811|positive regulation of cell-substrate adhesion;GO:0030198|extracellular matrix organization;","GO:0005576|extracellular region;GO:0062023|collagen-containing extracellular matrix;","GO:0005509|calcium ion binding;GO:0050840|extracellular matrix binding;","K17307","FBLN1_2; fibulin 1/2"]
["ENSRNOG00000011140",381,24.50989695,2817,181.8707586,0.134765463,-2.89147728,0,0,"down","yes","Prxl2a","protein_coding","chr16:16866603-16886433:-","gi|62079015|ref|NP_001014162.1|",1000,{"v":2e-130,"d":"2.00E-130"},"redox-regulatory protein FAM213A [Rattus norvegicus]","gi|62079014|ref|NM_001014140.1|",1346,0,"Rattus norvegicus similar to RIKEN cDNA 5730469M10 (RGD1309676), mRNA","Q6AXX6",389,{"v":7e-132,"d":"7.00E-132"},"Redox-regulatory protein FAM213A",".",".",".",".","pfam13911","AhpC-TSA_2","AhpC/TSA antioxidant enzyme. This family contains proteins related to alkyl hydro-peroxide reductase (AhpC) and thiol specific antioxidant (TSA).","GO:0045670|regulation of osteoclast differentiation;GO:0098869|cellular oxidant detoxification;","GO:0005576|extracellular region;GO:0005737|cytoplasm;","GO:0016209|antioxidant activity;",".","."]
["ENSRNOG00000016343",907,58.34770743,3942,254.5028508,0.229261508,-2.12493394,0,0,"down","yes","Dkk3","protein_coding","chr1:166238238-166280590:-","gi|404312665|ref|NP_612528.2|",1554,0,"dickkopf-related protein 3 precursor [Rattus norvegicus]","gi|404312664|ref|NM_138519.2|",5010,0,"Rattus norvegicus dickkopf WNT signaling pathway inhibitor 3 (Dkk3), mRNA","Q9QUN9",551,{"v":4e-180,"d":"4.00E-180"},"Dickkopf-related protein 3",".",".",".",".","pfam04706","Dickkopf_N","Dickkopf N-terminal cysteine-rich region. Dickkopf proteins are a class of Wnt antagonists. They possess two conserved cysteine-rich regions. This family represents the N-terminal one. The C-terminal region has been found to share significant sequence similarity to the colipase fold, pfam01114, pfam02740.","GO:0030325|adrenal gland development;GO:0032348|negative regulation of aldosterone biosynthetic process;GO:0045892|negative regulation of transcription, DNA-templated;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:2000065|negative regulation of cortisol biosynthetic process;GO:2000272|negative regulation of signaling receptor activity;","GO:0005615|extracellular space;","GO:0039706|co-receptor binding;GO:0048019|receptor antagonist activity;","K25493","DKK3; dickkopf 3"]
["ENSRNOG00000033215",427,27.4690971,2873,185.4862228,0.148092385,-2.755430637,0,0,"down","yes","RT1-Db1","protein_coding","chr20:4548666-4558258:-","gi|57114286|ref|NP_001008884.1|",1137,{"v":2e-139,"d":"2.00E-139"},"rano class II histocompatibility antigen, D-1 beta chain precursor [Rattus norvegicus]","gi|89214481|gb|AC120734.5|",4227,0,"Rattus norvegicus BAC CH230-220D1 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P18211",399,{"v":9e-126,"d":"9.00E-126"},"Rano class II histocompatibility antigen, D-1 beta chain",".",".",".",".","pfam00969","MHC_II_beta","Class II histocompatibility antigen, beta domain.","GO:0001916|positive regulation of T cell mediated cytotoxicity;GO:0001934|positive regulation of protein phosphorylation;GO:0002250|adaptive immune response;GO:0002381|immunoglobulin production involved in immunoglobulin mediated immune response;GO:0002437|inflammatory response to antigenic stimulus;GO:0002469|myeloid dendritic cell antigen processing and presentation;GO:0002491|antigen processing and presentation of endogenous peptide antigen via MHC class II;GO:0002503|peptide antigen assembly with MHC class II protein complex;GO:0002504|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;GO:0002842|positive regulation of T cell mediated immune response to tumor cell;GO:0002862|negative regulation of inflammatory response to antigenic stimulus;GO:0006955|immune response;GO:0006959|humoral immune response;GO:0007165|signal transduction;GO:0010033|response to organic substance;GO:0016045|detection of bacterium;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030225|macrophage differentiation;GO:0032653|regulation of interleukin-10 production;GO:0032673|regulation of interleukin-4 production;GO:0032689|negative regulation of interferon-gamma production;GO:0032831|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0033674|positive regulation of kinase activity;GO:0034341|response to interferon-gamma;GO:0035774|positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0042088|T-helper 1 type immune response;GO:0042130|negative regulation of T cell proliferation;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043382|positive regulation of memory T cell differentiation;GO:0043410|positive regulation of MAPK cascade;GO:0045622|regulation of T-helper cell differentiation;GO:0045657|positive regulation of monocyte differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0046598|positive regulation of viral entry into host cell;GO:0050852|T cell receptor signaling pathway;GO:0050870|positive regulation of T cell activation;GO:0051262|protein tetramerization;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071548|response to dexamethasone;GO:2000516|positive regulation of CD4-positive, alpha-beta T cell activation;","GO:0001772|immunological synapse;GO:0005575|cellular_component;GO:0005765|lysosomal membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0031902|late endosome membrane;GO:0042613|MHC class II protein complex;","GO:0003674|molecular_function;GO:0023026|MHC class II protein complex binding;GO:0030247|polysaccharide binding;GO:0032395|MHC class II receptor activity;GO:0042605|peptide antigen binding;GO:0042608|T cell receptor binding;GO:0042609|CD4 receptor binding;","K06752","MHC2; MHC class II antigen"]
["ENSRNOG00000020300",331,21.29337504,2621,169.2166342,0.125834999,-2.990394851,0,0,"down","yes","Lsp1","protein_coding","chr1:197614687-197648416:+","gi|162287322|ref|NP_001020591.1|",908,{"v":2e-111,"d":"2.00E-111"},"lymphocyte-specific protein 1 [Rattus norvegicus]","gi|33354295|gb|AC098563.6|",1479,0,"Rattus norvegicus 1 BAC CH230-123A15 (Children's Hospital Oakland Research Institute) complete sequence","P19973",295,{"v":2E-90,"d":"2.00E-90"},"Lymphocyte-specific protein 1",".",".",".",".","pfam02029","Caldesmon","Caldesmon.","GO:0006935|chemotaxis;GO:0006952|defense response;GO:0007165|signal transduction;GO:0098761|cellular response to interleukin-7;",".","GO:0003779|actin binding;","K14957","LSP1; lymphocyte-specific protein 1"]
["ENSRNOG00000064166",21,1.350939202,1867,120.536992,0.011207673,-6.479369409,0,0,"down","yes","Hmcn2","protein_coding","chr3:14588662-14738025:+","gi|602680780|ref|XP_007453195.1|",19650,0,"PREDICTED: LOW QUALITY PROTEIN: hemicentin-2 [Lipotes vexillifer]","gi|672045095|ref|XM_008761691.1|",5943,0,"PREDICTED: Rattus norvegicus hemicentin 2 (Hmcn2), transcript variant X2, mRNA","Q8NDA2",7828,0,"Hemicentin-2",".",".",".",".","pfam07474","G2F","G2F domain. Nidogen, an invariant component of basement membranes, is a multifunctional protein that interacts with most other major basement membrane proteins. The G2 fragment or (G2F domain) contains binding sites for collagen IV and perlecan. The structure is composed of an 11-stranded beta-barrel with a central helix. This domain is structurally related to that of green fluorescent protein pfam01353. A large surface patch on the beta-barrel is conserved in all metazoan nidogens.",".",".",".",".","."]
["ENSRNOG00000050792",218,14.02403552,2320,149.7835144,0.093628699,-3.416905385,0,0,"down","yes","Tnfaip6","protein_coding","chr3:36502188-36521649:+","gi|197304765|ref|NP_445834.1|",1480,0,"tumor necrosis factor-inducible gene 6 protein precursor [Rattus norvegicus]","gi|298908430|emb|FQ228783.1|",1408,0,"Rattus norvegicus TL0ADA51YN04 mRNA sequence","O08859",536,0,"Tumor necrosis factor-inducible gene 6 protein",".",".",".",".","pfam00431","CUB","CUB domain.","GO:0007155|cell adhesion;GO:0030335|positive regulation of cell migration;GO:0030728|ovulation;GO:0050728|negative regulation of inflammatory response;","GO:0005615|extracellular space;","GO:0003674|molecular_function;GO:0005540|hyaluronic acid binding;","K19018","TNFAIP6, TSG6; tumor necrosis factor-inducible gene 6 protein"]
["ENSRNOG00000021403",2235,143.7785293,6190,399.6379113,0.359771997,-1.474845197,0,0,"down","yes","ENSRNOG00000021403","lncRNA","chr6:31363548-31366108:+","gi|667242649|ref|XP_008571619.1|",1028,{"v":6e-131,"d":"6.00E-131"},"PREDICTED: rho-related GTP-binding protein RhoB, partial [Galeopterus variegatus]","gi|11968135|ref|NM_022542.1|",2133,0,"Rattus norvegicus ras homolog family member B (Rhob), mRNA","P62747",400,{"v":2E-132,"d":"2.00E-132"},"Rho-related GTP-binding protein RhoB",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0000281|mitotic cytokinesis;GO:0001525|angiogenesis;GO:0006886|intracellular protein transport;GO:0006915|apoptotic process;GO:0007015|actin filament organization;GO:0007155|cell adhesion;GO:0007163|establishment or maintenance of cell polarity;GO:0007264|small GTPase mediated signal transduction;GO:0008333|endosome to lysosome transport;GO:0008360|regulation of cell shape;GO:0010595|positive regulation of endothelial cell migration;GO:0016477|cell migration;GO:0030154|cell differentiation;GO:0030334|regulation of cell migration;GO:0030336|negative regulation of cell migration;GO:0030865|cortical cytoskeleton organization;GO:0032956|regulation of actin cytoskeleton organization;GO:0043065|positive regulation of apoptotic process;GO:0045766|positive regulation of angiogenesis;GO:0045786|negative regulation of cell cycle;GO:0061154|endothelial tube morphogenesis;GO:0070301|cellular response to hydrogen peroxide;GO:0071479|cellular response to ionizing radiation;","GO:0005634|nucleus;GO:0005769|early endosome;GO:0005770|late endosome;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0005938|cell cortex;GO:0010008|endosome membrane;GO:0016020|membrane;GO:0031410|cytoplasmic vesicle;GO:0031902|late endosome membrane;GO:0032154|cleavage furrow;GO:0042995|cell projection;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0019003|GDP binding;GO:0019901|protein kinase binding;","K07856","RHOB; Ras homolog gene family, member B"]
["ENSRNOG00000018991",2053,132.0703896,5887,380.0756678,0.347484464,-1.52497962,0,0,"down","yes","Gsn","protein_coding","chr3:18585172-18638402:+","gi|51854227|ref|NP_001004080.1|",3953,0,"gelsolin precursor [Rattus norvegicus]","gi|672045226|ref|XM_006234039.2|",2443,0,"PREDICTED: Rattus norvegicus gelsolin (Gsn), transcript variant X1, mRNA","Q68FP1",1527,0,"Gelsolin",".",".",".",".","pfam00626","Gelsolin","Gelsolin repeat.","GO:0006911|phagocytosis, engulfment;GO:0006915|apoptotic process;GO:0007417|central nervous system development;GO:0007568|aging;GO:0008154|actin polymerization or depolymerization;GO:0010628|positive regulation of gene expression;GO:0014003|oligodendrocyte development;GO:0014891|striated muscle atrophy;GO:0016192|vesicle-mediated transport;GO:0030031|cell projection assembly;GO:0030036|actin cytoskeleton organization;GO:0030041|actin filament polymerization;GO:0030042|actin filament depolymerization;GO:0030155|regulation of cell adhesion;GO:0031648|protein destabilization;GO:0035994|response to muscle stretch;GO:0042060|wound healing;GO:0042246|tissue regeneration;GO:0042989|sequestering of actin monomers;GO:0045010|actin nucleation;GO:0045471|response to ethanol;GO:0046597|negative regulation of viral entry into host cell;GO:0048015|phosphatidylinositol-mediated signaling;GO:0051014|actin filament severing;GO:0051016|barbed-end actin filament capping;GO:0051127|positive regulation of actin nucleation;GO:0051593|response to folic acid;GO:0051693|actin filament capping;GO:0055119|relaxation of cardiac muscle;GO:0060271|cilium assembly;GO:0071276|cellular response to cadmium ion;GO:0071346|cellular response to interferon-gamma;GO:0071801|regulation of podosome assembly;GO:0086003|cardiac muscle cell contraction;GO:0090527|actin filament reorganization;GO:0097017|renal protein absorption;GO:0097284|hepatocyte apoptotic process;GO:1902174|positive regulation of keratinocyte apoptotic process;GO:1903903|regulation of establishment of T cell polarity;GO:1903906|regulation of plasma membrane raft polarization;GO:1903909|regulation of receptor clustering;GO:1903923|positive regulation of protein processing in phagocytic vesicle;GO:1990000|amyloid fibril formation;GO:2001269|positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;","GO:0001726|ruffle;GO:0002102|podosome;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005925|focal adhesion;GO:0015629|actin cytoskeleton;GO:0016528|sarcoplasm;GO:0030027|lamellipodium;GO:0030478|actin cap;GO:0030864|cortical actin cytoskeleton;GO:0032991|protein-containing complex;GO:0043209|myelin sheath;GO:0045335|phagocytic vesicle;GO:0048471|perinuclear region of cytoplasm;","GO:0003779|actin binding;GO:0005509|calcium ion binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0036313|phosphatidylinositol 3-kinase catalytic subunit binding;GO:0045159|myosin II binding;GO:0051015|actin filament binding;","K05768","GSN; gelsolin"]
["ENSRNOG00000030210",41,2.637547966,1787,115.3720432,0.02286124,-5.450952534,0,0,"down","yes","Fndc1","protein_coding","chr1:47281844-47364259:+","gi|564325199|ref|XP_006227933.1|",5986,0,"PREDICTED: fibronectin type III domain-containing protein 1 isoform X1 [Rattus norvegicus]","gi|672034288|ref|XM_006227871.2|",6335,0,"PREDICTED: Rattus norvegicus fibronectin type III domain containing 1 (Fndc1), transcript variant X1, mRNA","Q2Q0I9",2176,0,"Fibronectin type III domain-containing protein 1",".",".",".",".","pfam00041","fn3","Fibronectin type III domain.","GO:0001934|positive regulation of protein phosphorylation;GO:0010666|positive regulation of cardiac muscle cell apoptotic process;GO:0051223|regulation of protein transport;GO:0071456|cellular response to hypoxia;","GO:0005576|extracellular region;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0016607|nuclear speck;GO:0031966|mitochondrial membrane;",".","K24484","FNDC1; fibronectin type III domain-containing protein 1"]
["ENSRNOG00000008749",1740,111.9349624,5312,342.9525985,0.326386104,-1.61534846,0,0,"down","yes","Col5a1","protein_coding","chr3:11208512-11354588:+","gi|564340137|ref|XP_006233935.1|",1669,0,"PREDICTED: collagen alpha-1(V) chain isoform X1 [Rattus norvegicus]","gi|672045035|ref|XM_006233873.2|",5470,0,"PREDICTED: Rattus norvegicus collagen, type V, alpha 1 (Col5a1), transcript variant X1, mRNA","Q9JI03",647,0,"Collagen alpha-1(V) chain",".",".",".",".","pfam01410","COLFI","Fibrillar collagen C-terminal domain. Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1 alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.","GO:0001568|blood vessel development;GO:0003007|heart morphogenesis;GO:0007155|cell adhesion;GO:0008150|biological_process;GO:0016477|cell migration;GO:0030198|extracellular matrix organization;GO:0030199|collagen fibril organization;GO:0032964|collagen biosynthetic process;GO:0035313|wound healing, spreading of epidermal cells;GO:0035989|tendon development;GO:0043588|skin development;GO:0045112|integrin biosynthetic process;GO:0048592|eye morphogenesis;GO:0051128|regulation of cellular component organization;GO:0097435|supramolecular fiber organization;GO:1903225|negative regulation of endodermal cell differentiation;","GO:0005581|collagen trimer;GO:0005588|collagen type V trimer;GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0031012|extracellular matrix;GO:0062023|collagen-containing extracellular matrix;","GO:0005201|extracellular matrix structural constituent;GO:0008201|heparin binding;GO:0043394|proteoglycan binding;GO:0048407|platelet-derived growth factor binding;","K19721","COL5AS; collagen type V/XI/XXIV/XXVII, alpha"]
["ENSRNOG00000000875",1477,95.0160572,4841,312.5439626,0.304008615,-1.717815887,0,0,"down","yes","ENSRNOG00000000875","protein_coding","chrX:134555479-134614928:+","gi|672089019|ref|XP_008771869.1|",1527,0,"PREDICTED: four and a half LIM domains protein 1 isoform X3 [Rattus norvegicus]","gi|672089018|ref|XM_008773647.1|",1223,0,"PREDICTED: Rattus norvegicus four and a half LIM domains 1 (Fhl1), transcript variant X7, mRNA","Q9WUH4",570,0,"Four and a half LIM domains protein 1",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.","GO:0003254|regulation of membrane depolarization;GO:0007517|muscle organ development;GO:0010972|negative regulation of G2/M transition of mitotic cell cycle;GO:0030154|cell differentiation;GO:0030308|negative regulation of cell growth;GO:0043268|positive regulation of potassium ion transport;GO:1901016|regulation of potassium ion transmembrane transporter activity;GO:2000134|negative regulation of G1/S transition of mitotic cell cycle;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0044325|ion channel binding;GO:0046872|metal ion binding;","K14365","FHL1, SLIM1; four and a half LIM domains protein 1"]
["ENSRNOG00000008057",48,3.087861033,1763,113.8225586,0.027128726,-5.204034878,0,0,"down","yes","ENSRNOG00000008057","protein_coding","chr7:132528895-132545052:+","gi|392341701|ref|XP_003754401.1|",2266,0,"PREDICTED: keratin, type II cytoskeletal 7 [Rattus norvegicus]","gi|672022401|ref|XM_003754353.3|",1476,0,"PREDICTED: Rattus norvegicus keratin 7 (Krt7), mRNA","Q6IG12",818,0,"Keratin, type II cytoskeletal 7",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0045095|keratin filament;","GO:0003674|molecular_function;","K07605","KRT2; type II keratin, basic"]
["ENSRNOG00000015667",32,2.058574022,1738,112.2085121,0.01834597,-5.768392986,0,0,"down","yes","Epcam","protein_coding","chr6:6878237-6896127:-","gi|25742698|ref|NP_612550.1|",1437,0,"epithelial cell adhesion molecule precursor [Rattus norvegicus]","gi|38197339|gb|BC061787.1|",1460,0,"Rattus norvegicus tumor-associated calcium signal transducer 1, mRNA (cDNA clone IMAGE:5623760)","O55159",558,0,"Epithelial cell adhesion molecule",".",".",".",".","pfam00086","Thyroglobulin_1","Thyroglobulin type-1 repeat. Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.","GO:0001657|ureteric bud development;GO:0008284|positive regulation of cell proliferation;GO:0023019|signal transduction involved in regulation of gene expression;GO:0043066|negative regulation of apoptotic process;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048863|stem cell differentiation;GO:0098742|cell-cell adhesion via plasma-membrane adhesion molecules;GO:2000048|negative regulation of cell-cell adhesion mediated by cadherin;GO:2000147|positive regulation of cell motility;GO:2000648|positive regulation of stem cell proliferation;","GO:0005886|plasma membrane;GO:0005923|bicellular tight junction;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0016328|lateral plasma membrane;","GO:0044877|protein-containing complex binding;GO:0098641|cadherin binding involved in cell-cell adhesion;","K06737","EPCAM, TACSTD1, CD326; epithelial cell adhesion molecule"]
["ENSRNOG00000011647",979,62.97949898,3840,247.9175411,0.254034058,-1.976906165,0,0,"down","yes","S100a6","protein_coding","chr2:176100899-176102180:+","gi|880937086|ref|XP_005080297.2|",405,{"v":1e-47,"d":"1.00E-47"},"PREDICTED: protein S100-A6 isoform X1 [Mesocricetus auratus]","gi|298906521|emb|FQ222088.1|",458,0,"Rattus norvegicus TL0ADA29YD14 mRNA sequence","P05964",152,{"v":2E-46,"d":"2.00E-46"},"Protein S100-A6",".",".",".",".","pfam01023","S_100","S-100/ICaBP type calcium binding domain. The S-100 domain is a subfamily of the EF-hand calcium binding proteins.","GO:0034220|ion transmembrane transport;GO:0098586|cellular response to virus;","GO:0001726|ruffle;GO:0005634|nucleus;GO:0005635|nuclear envelope;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0048471|perinuclear region of cytoplasm;","GO:0005509|calcium ion binding;GO:0005523|tropomyosin binding;GO:0008270|zinc ion binding;GO:0015075|ion transmembrane transporter activity;GO:0042803|protein homodimerization activity;GO:0044548|S100 protein binding;GO:0048306|calcium-dependent protein binding;","K23764","S100A6; protein S100-A6"]
["ENSRNOG00000011913",1427,91.79953529,4580,295.6933172,0.310455225,-1.687542883,0,0,"down","yes","Cp","protein_coding","chr2:102439624-102498075:+","gi|401461786|ref|NP_036664.2|",5667,0,"ceruloplasmin isoform 1 precursor [Rattus norvegicus]","gi|401461785|ref|NM_012532.2|",3732,0,"Rattus norvegicus ceruloplasmin (ferroxidase) (Cp), transcript variant 1, mRNA","P13635",2169,0,"Ceruloplasmin","VNG1187G",60.1,2E-8,"COG2132","pfam07731","Cu-oxidase_2","Multicopper oxidase. This entry contains many divergent copper oxidase-like domains that are not recognized by the pfam00394 model.","GO:0001889|liver development;GO:0006811|ion transport;GO:0006826|iron ion transport;GO:0006879|cellular iron ion homeostasis;GO:0007565|female pregnancy;GO:0007568|aging;GO:0007584|response to nutrient;GO:0007595|lactation;GO:0015679|plasma membrane copper ion transport;GO:0030324|lung development;GO:0046688|response to copper ion;GO:0055072|iron ion homeostasis;GO:0060056|mammary gland involution;","GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0046658|anchored component of plasma membrane;","GO:0004322|ferroxidase activity;GO:0005507|copper ion binding;GO:0016491|oxidoreductase activity;GO:0051087|chaperone binding;","K13624","CP; ceruloplasmin [EC:1.16.3.1]"]
["ENSRNOG00000023781",1834,117.9820236,5267,340.0473148,0.346957669,-1.52716844,0,0,"down","yes","Plec","protein_coding","chr7:107887764-107945467:-","gi|256221671|ref|NP_001157771.1|",10359,0,"plectin isoform 1hij [Rattus norvegicus]","gi|672059540|ref|XM_006241870.2|",15290,0,"PREDICTED: Rattus norvegicus plectin (Plec), transcript variant X1, mRNA","P30427",3959,0,"Plectin","ECU09g0290",169,{"v":7e-42,"d":"7.00E-42"},"COG5069","pfam03501","S10_plectin","Plectin/S10 domain. This presumed domain is found at the N-terminus of some isoforms of the cytoskeletal muscle protein plectin as well as the ribosomal S10 protein. This domain may be involved in RNA binding.","GO:0000902|cell morphogenesis;GO:0002522|leukocyte migration involved in immune response;GO:0003334|keratinocyte development;GO:0006469|negative regulation of protein kinase activity;GO:0006997|nucleus organization;GO:0007005|mitochondrion organization;GO:0007015|actin filament organization;GO:0007519|skeletal muscle tissue development;GO:0007565|female pregnancy;GO:0007584|response to nutrient;GO:0010467|gene expression;GO:0010761|fibroblast migration;GO:0010818|T cell chemotaxis;GO:0014866|skeletal myofibril assembly;GO:0019226|transmission of nerve impulse;GO:0022011|myelination in peripheral nervous system;GO:0022904|respiratory electron transport chain;GO:0030036|actin cytoskeleton organization;GO:0030216|keratinocyte differentiation;GO:0030855|epithelial cell differentiation;GO:0031532|actin cytoskeleton reorganization;GO:0031581|hemidesmosome assembly;GO:0031668|cellular response to extracellular stimulus;GO:0032094|response to food;GO:0032287|peripheral nervous system myelin maintenance;GO:0034332|adherens junction organization;GO:0034613|cellular protein localization;GO:0035264|multicellular organism growth;GO:0042060|wound healing;GO:0043114|regulation of vascular permeability;GO:0043588|skin development;GO:0043933|protein-containing complex subunit organization;GO:0045104|intermediate filament cytoskeleton organization;GO:0045109|intermediate filament organization;GO:0045214|sarcomere organization;GO:0045445|myoblast differentiation;GO:0048741|skeletal muscle fiber development;GO:0048870|cell motility;GO:0055013|cardiac muscle cell development;GO:0061436|establishment of skin barrier;GO:0070584|mitochondrion morphogenesis;GO:0071260|cellular response to mechanical stimulus;GO:0071464|cellular response to hydrostatic pressure;GO:0071498|cellular response to fluid shear stress;GO:0120193|tight junction organization;GO:2000689|actomyosin contractile ring assembly actin filament organization;GO:2000983|regulation of ATP citrate synthase activity;","GO:0005737|cytoplasm;GO:0005741|mitochondrial outer membrane;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0005882|intermediate filament;GO:0005903|brush border;GO:0005925|focal adhesion;GO:0009925|basal plasma membrane;GO:0016020|membrane;GO:0016324|apical plasma membrane;GO:0016528|sarcoplasm;GO:0030016|myofibril;GO:0030018|Z disc;GO:0030056|hemidesmosome;GO:0030424|axon;GO:0030425|dendrite;GO:0042383|sarcolemma;GO:0043034|costamere;GO:0043209|myelin sheath;GO:0043292|contractile fiber;GO:0045111|intermediate filament cytoskeleton;GO:0048471|perinuclear region of cytoplasm;GO:0071944|cell periphery;","GO:0002162|dystroglycan binding;GO:0003779|actin binding;GO:0005198|structural molecule activity;GO:0005200|structural constituent of cytoskeleton;GO:0008092|cytoskeletal protein binding;GO:0008307|structural constituent of muscle;GO:0030506|ankyrin binding;GO:0043621|protein self-association;GO:0047485|protein N-terminus binding;GO:0051015|actin filament binding;","K10388","PLEC; plectin"]
["ENSRNOG00000013481",407,26.18248834,2556,165.0201133,0.158662407,-2.655967756,0,0,"down","yes","Cdh11","protein_coding","chr19:2148458-2304272:+","gi|281427192|ref|NP_445844.1|",4073,0,"cadherin-11 [Rattus norvegicus]","gi|672083958|ref|XM_006255059.2|",3231,0,"PREDICTED: Rattus norvegicus cadherin 11 (Cdh11), transcript variant X1, mRNA","P55288",1555,0,"Cadherin-11",".",".",".",".","pfam01049","Cadherin_C","Cadherin cytoplasmic region. Cadherins are vital in cell-cell adhesion during tissue differentiation. Cadherins are linked to the cytoskeleton by catenins. Catenins bind to the cytoplasmic tail of the cadherin. Cadherins cluster to form foci of homophilic binding units. A key determinant to the strength of the binding that it is mediated by cadherins is the juxtamembrane region of the cadherin. This region induces clustering and also binds to the protein p120ctn.","GO:0000902|cell morphogenesis;GO:0007043|cell-cell junction assembly;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007275|multicellular organism development;GO:0016339|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0021957|corticospinal tract morphogenesis;GO:0034332|adherens junction organization;GO:0050804|modulation of chemical synaptic transmission;GO:0098609|cell-cell adhesion;GO:0098742|cell-cell adhesion via plasma-membrane adhesion molecules;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005912|adherens junction;GO:0016021|integral component of membrane;GO:0016342|catenin complex;GO:0045202|synapse;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098978|glutamatergic synapse;","GO:0005509|calcium ion binding;GO:0045296|cadherin binding;","K06803","CDH11; cadherin 11, type 2, OB-cadherin"]
["ENSRNOG00000046222",76,4.889113302,1665,107.4954963,0.045482029,-4.458559568,0,0,"down","yes","Ceacam4","protein_coding","chr1:80376648-80382915:+","gi|755583|gb|AAC52590.1|",746,{"v":2e-94,"d":"2.00E-94"},"C-CAM4 [Rattus norvegicus]","gi|755582|gb|U23055.1|RNU23055",884,0,"Rattus norvegicus C-CAM4 gene, partial cds","P16573",268,{"v":6e-82,"d":"6.00E-82"},"Carcinoembryonic antigen-related cell adhesion molecule 1",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0006909|phagocytosis;GO:0030317|flagellated sperm motility;","GO:0005576|extracellular region;",".","K06499","CEACAM, CD66; carcinoembryonic antigen-related cell adhesion molecule"]
["ENSRNOG00000046699",17,1.093617449,1588,102.5242331,0.010666917,-6.550712975,0,0,"down","yes","Slpi","protein_coding","chr3:153082369-153084453:-","gi|149042957|gb|EDL96531.1|",659,{"v":8e-86,"d":"8.00E-86"},"rCG32428, isoform CRA_a [Rattus norvegicus]","gi|23451267|gb|AF421377.1|",444,0,"Rattus norvegicus secretory leukocyte protease inhibitor precursor, mRNA, complete cds","P97430",217,{"v":3e-71,"d":"3.00E-71"},"Antileukoproteinase",".",".",".",".","pfam00095","WAP","WAP-type (Whey Acidic Protein) 'four-disulfide core'.","GO:0006955|immune response;GO:0010951|negative regulation of endopeptidase activity;GO:0019731|antibacterial humoral response;GO:0032091|negative regulation of protein binding;GO:0032496|response to lipopolysaccharide;GO:0035821|modification of morphology or physiology of other organism;GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0050728|negative regulation of inflammatory response;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005794|Golgi apparatus;","GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0003729|mRNA binding;GO:0004866|endopeptidase inhibitor activity;GO:0004867|serine-type endopeptidase inhibitor activity;GO:0019899|enzyme binding;","K23638","SLPI, WFDC4; antileukoproteinase"]
["ENSRNOG00000010107",556,35.76772363,2838,183.2265577,0.195210367,-2.356898421,0,0,"down","yes","Palldl1","protein_coding","chr16:27981354-28621337:+","gi|568954992|ref|XP_006509566.1|",6008,0,"PREDICTED: palladin isoform X2 [Mus musculus]","gi|568954991|ref|XM_006509503.1|",4559,0,"PREDICTED: Mus musculus palladin, cytoskeletal associated protein (Palld), transcript variant X2, mRNA","Q9ET54",2309,0,"Palladin",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.",".",".",".",".","."]
["ENSRNOG00000063244",497,31.97222778,2702,174.4461448,0.1832785,-2.447890537,0,0,"down","yes","Mpeg1","protein_coding","chr1:209452133-209458855:+","gi|768711622|ref|NP_072139.2|",3691,0,"macrophage-expressed gene 1 protein precursor [Rattus norvegicus]","gi|672039844|ref|XM_008760261.1|",4306,0,"PREDICTED: Rattus norvegicus macrophage expressed 1 (Mpeg1), transcript variant X2, mRNA","Q9WV57",1402,0,"Macrophage-expressed gene 1 protein",".",".",".",".","pfam01823","MACPF","MAC/Perforin domain. The membrane-attack complex (MAC) of the complement system forms transmembrane channels. These channels disrupt the phospholipid bilayer of target cells, leading to cell lysis and death. A number of proteins participate in the assembly of the MAC. Freshly activated C5b binds to C6 to form a C5b-6 complex, then to C7 forming the C5b-7 complex. The C5b-7 complex binds to C8, which is composed of three chains (alpha, beta, and gamma), thus forming the C5b-8 complex. C5b-8 subsequently binds to C9 and acts as a catalyst in the polymerization of C9. Active MAC has a subunit composition of C5b-C6-C7-C8-C9{n}. Perforin is a protein found in cytolytic T-cell and killer cells. In the presence of calcium, perforin polymerizes into transmembrane tubules and is capable of lysing, non-specifically, a variety of target cells. There are a number of regions of similarity in the sequences of complement components C6, C7, C8-alpha, C8-beta, C9 and perforin. The X-ray crystal structure of a MACPF domain reveals that it shares a common fold with bacterial cholesterol dependent cytolysins (pfam01289) such as perfringolysin O. Three key pieces of evidence suggests that MACPF domains and CDCs are homologous: Functional similarity (pore formation), conservation of three glycine residues at a hinge in both families and conservation of a complex core fold.",".",".",".",".","."]
["ENSRNOG00000064734",0,0.032165219,3345,215.9594205,0.000148941,-12.71297111,0,0,"down","yes","ENSRNOG00000064734","protein_coding","chr3:107572184-107574858:+","gi|45219799|gb|AAH67002.1|",343,{"v":3e-33,"d":"3.00E-33"},"4632419I22Rik protein [Mus musculus]","gi|315434303|gb|AC243170.5|",1142,0,"Rattus norvegicus Y Chr BAC RNAEX-212I22 (Amplicon Express Rat SHR-Akr BAC library) complete sequence","P26804",106,{"v":1E-22,"d":"1.00E-22"},"Envelope glycoprotein",".",".",".",".","pfam00429","TLV_coat","ENV polyprotein (coat polyprotein).",".",".",".",".","."]
["ENSRNOG00000007247",11,0.70763482,1523,98.32771226,0.007196698,-7.118449227,0,0,"down","yes","A2ml1","protein_coding","chr4:161814708-161857343:-","gi|293347095|ref|XP_001066684.2|",7732,0,"PREDICTED: ovostatin homolog 2 isoform X1 [Rattus norvegicus]","gi|672018783|ref|XM_001066684.4|",4695,0,"PREDICTED: Rattus norvegicus alpha-2-macroglobulin-like 1 (A2ml1), transcript variant X1, mRNA","Q3UU35",2573,0,"Ovostatin homolog","TM0984",65.9,1e-09,"COG2373","pfam07678","A2M_comp","A-macroglobulin complement component. This family includes the complement components region of the alpha-2-macroglobulin family.","GO:0010951|negative regulation of endopeptidase activity;","GO:0005615|extracellular space;","GO:0004867|serine-type endopeptidase inhibitor activity;","K23593","A2ML; alpha-2-macroglobulin-like protein"]
["ENSRNOG00000005858",0,0.032165219,3264,210.7299099,0.000152637,-12.67760596,0,0,"down","yes","Kap","protein_coding","chr4:166674595-166677639:-","gi|16258815|ref|NP_434689.1|",450,{"v":3e-53,"d":"3.00E-53"},"kidney androgen-regulated protein precursor [Rattus norvegicus]","gi|16258814|ref|NM_052802.1|",698,0,"Rattus norvegicus kidney androgen regulated protein (Kap), mRNA","Q62781",177,{"v":1E-54,"d":"1.00E-54"},"Kidney androgen-regulated protein",".",".",".",".","pfam15222","KAR","Kidney androgen-regulated. The function of this family is unknown.",".","GO:0005576|extracellular region;",".",".","."]
["ENSRNOG00000027811",312,20.07109671,2157,139.2599313,0.144126861,-2.794588862,0,0,"down","yes","Lilrb4","protein_coding","chr1:69805250-69810660:-","gi|564326168|ref|XP_006228300.1|",1885,0,"PREDICTED: leukocyte immunoglobulin-like receptor, subfamily B, member 4 isoform X2 [Rattus norvegicus]","gi|672034964|ref|XM_006228238.2|",1340,0,"PREDICTED: Rattus norvegicus leukocyte immunoglobulin-like receptor, subfamily B, member 4 (Lilrb4), transcript variant X3, mRNA","Q64281",446,{"v":3E-153,"d":"3.00E-153"},"Leukocyte immunoglobulin-like receptor subfamily B member 4",".",".",".",".","pfam13927","Ig_3","Immunoglobulin domain. This family contains immunoglobulin-like domains.","GO:0002507|tolerance induction;GO:0002669|positive regulation of T cell anergy;GO:0002725|negative regulation of T cell cytokine production;GO:0002774|Fc receptor mediated inhibitory signaling pathway;GO:0031623|receptor internalization;GO:0032682|negative regulation of chemokine production;GO:0032689|negative regulation of interferon-gamma production;GO:0032691|negative regulation of interleukin-1 beta production;GO:0032693|negative regulation of interleukin-10 production;GO:0032703|negative regulation of interleukin-2 production;GO:0032714|negative regulation of interleukin-5 production;GO:0032715|negative regulation of interleukin-6 production;GO:0042130|negative regulation of T cell proliferation;GO:0043124|negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043378|positive regulation of CD8-positive, alpha-beta T cell differentiation;GO:0043409|negative regulation of MAPK cascade;GO:0045584|negative regulation of cytotoxic T cell differentiation;GO:0045591|positive regulation of regulatory T cell differentiation;GO:0045671|negative regulation of osteoclast differentiation;GO:0046007|negative regulation of activated T cell proliferation;GO:0050860|negative regulation of T cell receptor signaling pathway;GO:0061099|negative regulation of protein tyrosine kinase activity;GO:0071659|negative regulation of IP-10 production;GO:0140105|interleukin-10-mediated signaling pathway;GO:1900016|negative regulation of cytokine production involved in inflammatory response;GO:1900181|negative regulation of protein localization to nucleus;GO:1902894|negative regulation of pri-miRNA transcription by RNA polymerase II;GO:2000272|negative regulation of signaling receptor activity;GO:2000524|negative regulation of T cell costimulation;","GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0019903|protein phosphatase binding;GO:0030293|transmembrane receptor protein tyrosine kinase inhibitor activity;GO:0030547|receptor inhibitor activity;","K06512","LILR, CD85; leukocyte immunoglobulin-like receptor"]
["ENSRNOG00000047393",12,0.771965258,1464,94.51856254,0.00816734,-6.935917957,0,0,"down","yes","Krt18","protein_coding","chr7:133157475-133161166:+","gi|68534953|ref|NP_446428.1|",1737,0,"keratin, type I cytoskeletal 18 [Rattus norvegicus]","gi|68534952|ref|NM_053976.1|",1369,0,"Rattus norvegicus keratin 18, type I (Krt18), mRNA","Q5BJY9",673,0,"Keratin, type I cytoskeletal 18",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0009750|response to fructose;GO:0031667|response to nutrient levels;GO:0033209|tumor necrosis factor-mediated signaling pathway;GO:0043000|Golgi to plasma membrane CFTR protein transport;GO:0043066|negative regulation of apoptotic process;GO:0045104|intermediate filament cytoskeleton organization;GO:0070365|hepatocyte differentiation;GO:0072497|mesenchymal stem cell differentiation;GO:0097191|extrinsic apoptotic signaling pathway;GO:0097284|hepatocyte apoptotic process;GO:1902488|cholangiocyte apoptotic process;","GO:0005615|extracellular space;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005815|microtubule organizing center;GO:0005829|cytosol;GO:0005882|intermediate filament;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016363|nuclear matrix;GO:0032991|protein-containing complex;GO:0034451|centriolar satellite;GO:0045095|keratin filament;GO:0071944|cell periphery;","GO:0003674|molecular_function;GO:0005198|structural molecule activity;GO:0097110|scaffold protein binding;","K07604","KRT1; type I keratin, acidic"]
["ENSRNOG00000020197",305,19.62078365,2125,137.1939518,0.143014932,-2.805762313,0,0,"down","yes","Cd248","protein_coding","chr1:202373676-202376240:+","gi|157821557|ref|NP_001099795.1|",3185,0,"endosialin precursor [Rattus norvegicus]","gi|157821556|ref|NM_001106325.1|",2565,0,"Rattus norvegicus CD248 molecule (Cd248), mRNA","Q91V98",1156,0,"Endosialin",".",".",".",".","pfam14670","FXa_inhibition","Coagulation Factor Xa inhibitory site. This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.","GO:0008284|positive regulation of cell proliferation;GO:0016477|cell migration;GO:0048535|lymph node development;GO:0060033|anatomical structure regression;GO:2000353|positive regulation of endothelial cell apoptotic process;","GO:0005737|cytoplasm;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0005509|calcium ion binding;GO:0050840|extracellular matrix binding;GO:1990430|extracellular matrix protein binding;","K06706","CD248, CD164L1; CD248 antigen, endosialin"]
["ENSRNOG00000004763",143,9.19925266,1702,109.8842851,0.083717637,-3.578324604,0,0,"down","yes","Sirpa","protein_coding","chr3:116819726-116858098:+","gi|29427383|sp|P97710.1|SHPS1_RAT",2366,0,"RecName: Full=Tyrosine-protein phosphatase non-receptor type substrate 1; Short=SHP substrate 1; Short=SHPS-1; AltName: Full=Brain Ig-like molecule with tyrosine-based activation motifs; Short=Bit; AltName: Full=CD172 antigen-like family member A; AltName: Full=Inhibitory receptor SHPS-1; AltName: Full=Macrophage fusion receptor; AltName: Full=Macrophage membrane protein MFP150; AltName: Full=Signal-regulatory protein alpha-1; Short=Sirp-alpha-1; AltName: CD_antigen=CD172a; Flags: Precursor","gi|672046774|ref|XM_006234951.2|",3825,0,"PREDICTED: Rattus norvegicus signal-regulatory protein alpha (Sirpa), transcript variant X1, mRNA","P97710",915,0,"Tyrosine-protein phosphatase non-receptor type substrate 1",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0001933|negative regulation of protein phosphorylation;GO:0002244|hematopoietic progenitor cell differentiation;GO:0006910|phagocytosis, recognition;GO:0006911|phagocytosis, engulfment;GO:0007010|cytoskeleton organization;GO:0007015|actin filament organization;GO:0007160|cell-matrix adhesion;GO:0010468|regulation of gene expression;GO:0016477|cell migration;GO:0032649|regulation of interferon-gamma production;GO:0032651|regulation of interleukin-1 beta production;GO:0032675|regulation of interleukin-6 production;GO:0032680|regulation of tumor necrosis factor production;GO:0032688|negative regulation of interferon-beta production;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0034113|heterotypic cell-cell adhesion;GO:0035696|monocyte extravasation;GO:0045019|negative regulation of nitric oxide biosynthetic process;GO:0045428|regulation of nitric oxide biosynthetic process;GO:0046329|negative regulation of JNK cascade;GO:0050728|negative regulation of inflammatory response;GO:0050765|negative regulation of phagocytosis;GO:0050766|positive regulation of phagocytosis;GO:0050790|regulation of catalytic activity;GO:0050870|positive regulation of T cell activation;GO:0070301|cellular response to hydrogen peroxide;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0071222|cellular response to lipopolysaccharide;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071349|cellular response to interleukin-12;GO:0071641|negative regulation of macrophage inflammatory protein 1 alpha production;GO:0071650|negative regulation of chemokine (C-C motif) ligand 5 production;GO:0097530|granulocyte migration;GO:1900016|negative regulation of cytokine production involved in inflammatory response;GO:1903720|negative regulation of I-kappaB phosphorylation;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;","GO:0005515|protein binding;GO:0017124|SH3 domain binding;GO:0019903|protein phosphatase binding;GO:0030695|GTPase regulator activity;GO:0045309|protein phosphorylated amino acid binding;GO:0086080|protein binding involved in heterotypic cell-cell adhesion;GO:0098632|cell-cell adhesion mediator activity;GO:1990405|protein antigen binding;GO:1990782|protein tyrosine kinase binding;","K06551","SIRPA_B1_G, CD172; signal-regulatory protein alpha/beta1/gamma"]
["ENSRNOG00000018740",339,21.80801854,2200,142.0360912,0.153538571,-2.703326965,0,0,"down","yes","Ugt1a3","protein_coding","chr9:88713184-88808465:+","gi|89276778|ref|NP_001034780.1|",2854,0,"UDP-glucuronosyltransferase 1-6 precursor [Rattus norvegicus]","gi|311771705|ref|NM_001039691.2|",2339,0,"Rattus norvegicus UDP glucuronosyltransferase 1 family, polypeptide A6 (Ugt1a6), transcript variant 1, mRNA","P08430",1094,0,"UDP-glucuronosyltransferase 1-6","CAC2716",73.2,{"v":8e-13,"d":"8.00E-13"},"COG1819","pfam00201","UDPGT","UDP-glucoronosyl and UDP-glucosyl transferase.","GO:0001889|liver development;GO:0006711|estrogen catabolic process;GO:0006789|bilirubin conjugation;GO:0006805|xenobiotic metabolic process;GO:0006953|acute-phase response;GO:0007584|response to nutrient;GO:0008150|biological_process;GO:0008202|steroid metabolic process;GO:0008210|estrogen metabolic process;GO:0009410|response to xenobiotic stimulus;GO:0010033|response to organic substance;GO:0014070|response to organic cyclic compound;GO:0018411|protein glucuronidation;GO:0018880|4-chlorobiphenyl metabolic process;GO:0019439|aromatic compound catabolic process;GO:0031100|animal organ regeneration;GO:0032496|response to lipopolysaccharide;GO:0032782|bile acid secretion;GO:0032870|cellular response to hormone stimulus;GO:0042594|response to starvation;GO:0043086|negative regulation of catalytic activity;GO:0043434|response to peptide hormone;GO:0045471|response to ethanol;GO:0045922|negative regulation of fatty acid metabolic process;GO:0046226|coumarin catabolic process;GO:0048545|response to steroid hormone;GO:0051384|response to glucocorticoid;GO:0051552|flavone metabolic process;GO:0052695|cellular glucuronidation;GO:0052696|flavonoid glucuronidation;GO:0052697|xenobiotic glucuronidation;GO:0070640|vitamin D3 metabolic process;GO:0070980|biphenyl catabolic process;GO:0071361|cellular response to ethanol;GO:0071385|cellular response to glucocorticoid stimulus;GO:0071392|cellular response to estradiol stimulus;GO:0071407|cellular response to organic cyclic compound;GO:0071466|cellular response to xenobiotic stimulus;GO:1904224|negative regulation of glucuronosyltransferase activity;GO:2001030|negative regulation of cellular glucuronidation;","GO:0005575|cellular_component;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0032991|protein-containing complex;GO:0034663|endoplasmic reticulum chaperone complex;GO:0043231|intracellular membrane-bounded organelle;GO:0070069|cytochrome complex;","GO:0001972|retinoic acid binding;GO:0003674|molecular_function;GO:0004857|enzyme inhibitor activity;GO:0005496|steroid binding;GO:0015020|glucuronosyltransferase activity;GO:0019899|enzyme binding;GO:0042803|protein homodimerization activity;GO:0044877|protein-containing complex binding;GO:0046982|protein heterodimerization activity;","K00699","UGT; glucuronosyltransferase [EC:2.4.1.17]"]
["ENSRNOG00000056756",1461,93.98677019,4352,280.9732132,0.334504379,-1.579902998,0,0,"down","yes","Actn1","protein_coding","chr6:98998556-99093251:-","gi|49256643|gb|AAH74001.1|",4801,0,"Actn1 protein [Rattus norvegicus]","gi|49256642|gb|BC074001.1|",3667,0,"Rattus norvegicus actinin, alpha 1, mRNA (cDNA clone MGC:91658 IMAGE:7099133), complete cds","Q9Z1P2",1822,0,"Alpha-actinin-1","SPAC15A10.08",270,{"v":6e-77,"d":"6.00E-77"},"COG5069","pfam00307","CH","Calponin homology (CH) domain. The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.","GO:0007015|actin filament organization;GO:0030036|actin cytoskeleton organization;GO:0030220|platelet formation;GO:0036344|platelet morphogenesis;GO:0045214|sarcomere organization;GO:0045893|positive regulation of transcription, DNA-templated;GO:0048041|focal adhesion assembly;GO:0048741|skeletal muscle fiber development;GO:0051017|actin filament bundle assembly;GO:0051271|negative regulation of cellular component movement;GO:0051639|actin filament network formation;GO:0055001|muscle cell development;GO:0099173|postsynapse organization;","GO:0001725|stress fiber;GO:0001726|ruffle;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0005903|brush border;GO:0005911|cell-cell junction;GO:0005915|zonula adherens;GO:0005916|fascia adherens;GO:0005923|bicellular tight junction;GO:0005925|focal adhesion;GO:0016328|lateral plasma membrane;GO:0030017|sarcomere;GO:0030018|Z disc;GO:0030027|lamellipodium;GO:0030054|cell junction;GO:0030486|smooth muscle dense body;GO:0030864|cortical actin cytoskeleton;GO:0031252|cell leading edge;GO:0042383|sarcolemma;GO:0042995|cell projection;GO:0043197|dendritic spine;GO:0090636|outer dense plaque of desmosome;GO:0090637|inner dense plaque of desmosome;GO:0097433|dense body;GO:0098978|glutamatergic synapse;GO:1990357|terminal web;","GO:0003725|double-stranded RNA binding;GO:0003779|actin binding;GO:0005178|integrin binding;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0005519|cytoskeletal regulatory protein binding;GO:0017166|vinculin binding;GO:0019904|protein domain specific binding;GO:0030374|nuclear receptor transcription coactivator activity;GO:0042803|protein homodimerization activity;GO:0044325|ion channel binding;GO:0051015|actin filament binding;GO:0051393|alpha-actinin binding;GO:0099186|structural constituent of postsynapse;","K05699","ACTN1_4; actinin alpha 1/4"]
["ENSRNOG00000023320",7,0.450313067,1531,98.84420713,4.555786E-3,-7.778084265,0,0,"down","yes","Tspan1","protein_coding","chr5:129646993-129652017:-","gi|51948442|ref|NP_001004236.1|",1071,{"v":1E-142,"d":"1.00E-142"},"tetraspanin-1 [Rattus norvegicus]","gi|51948441|ref|NM_001004236.1|",1231,0,"Rattus norvegicus tetraspanin 1 (Tspan1), mRNA","Q6AYR9",417,{"v":4e-144,"d":"4.00E-144"},"Tetraspanin-1",".",".",".",".","pfam00335","Tetraspannin","Tetraspanin family.","GO:0050821|protein stabilization;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005765|lysosomal membrane;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0030054|cell junction;GO:0031982|vesicle;GO:0043231|intracellular membrane-bounded organelle;GO:0048471|perinuclear region of cytoplasm;","GO:0003674|molecular_function;","K17348","TSPAN1; tetraspanin-1"]
["ENSRNOG00000009037",460,29.59200157,2448,158.0474324,0.18723494,-2.417078411,0,0,"down","yes","Sulf1","protein_coding","chr5:6362911-6525584:-","gi|19705485|ref|NP_599205.1|",4376,0,"extracellular sulfatase Sulf-1 precursor [Rattus norvegicus]","gi|672051791|ref|XM_008763486.1|",5163,0,"PREDICTED: Rattus norvegicus sulfatase 1 (Sulf1), transcript variant X1, mRNA","Q8VI60",1687,0,"Extracellular sulfatase Sulf-1","yidJ",100,{"v":8e-21,"d":"8.00E-21"},"COG3119","pfam12548","DUF3740","Sulfatase protein. This domain family is found in eukaryotes, and is typically between 144 and 173 amino acids in length. The family is found in association with pfam00884.","GO:0001502|cartilage condensation;GO:0001822|kidney development;GO:0001937|negative regulation of endothelial cell proliferation;GO:0002063|chondrocyte development;GO:0003094|glomerular filtration;GO:0007155|cell adhesion;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0014846|esophagus smooth muscle contraction;GO:0016525|negative regulation of angiogenesis;GO:0030177|positive regulation of Wnt signaling pathway;GO:0030201|heparan sulfate proteoglycan metabolic process;GO:0030336|negative regulation of cell migration;GO:0030513|positive regulation of BMP signaling pathway;GO:0032836|glomerular basement membrane development;GO:0035860|glial cell-derived neurotrophic factor receptor signaling pathway;GO:0036022|limb joint morphogenesis;GO:0040036|regulation of fibroblast growth factor receptor signaling pathway;GO:0040037|negative regulation of fibroblast growth factor receptor signaling pathway;GO:0048010|vascular endothelial growth factor receptor signaling pathway;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0048706|embryonic skeletal system development;GO:0051216|cartilage development;GO:0060348|bone development;GO:0060384|innervation;GO:0060686|negative regulation of prostatic bud formation;","GO:0005615|extracellular space;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005795|Golgi stack;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0045121|membrane raft;","GO:0004065|arylsulfatase activity;GO:0005509|calcium ion binding;GO:0005539|glycosaminoglycan binding;GO:0008449|N-acetylglucosamine-6-sulfatase activity;","K14607","SULF; extracellular sulfatase Sulf [EC:3.1.6.-]"]
["ENSRNOG00000037853",149,9.58523529,1685,108.7867335,0.088110333,-3.504544975,0,0,"down","yes","Rarres1","protein_coding","chr2:151749715-151783978:-","gi|62339361|ref|NP_001014790.1|",1366,0,"retinoic acid receptor responder protein 1 precursor [Rattus norvegicus]","gi|114205614|gb|BC105631.1|",1329,0,"Rattus norvegicus retinoic acid receptor responder (tazarotene induced) 1, mRNA (cDNA clone MGC:124894 IMAGE:7386690), complete cds","P49788",405,{"v":4e-138,"d":"4.00E-138"},"Retinoic acid receptor responder protein 1",".",".",".",".","pfam06907","Latexin","Latexin. This family consists of several animal specific latexin proteins. Latexin is a carboxypeptidase A inhibitor and is expressed in a cell type-specific manner in both central and peripheral nervous systems in the rat.","GO:0008285|negative regulation of cell proliferation;GO:0010951|negative regulation of endopeptidase activity;","GO:0005615|extracellular space;","GO:0008191|metalloendopeptidase inhibitor activity;","K23595","RARRES1; retinoic acid receptor responder protein 1"]
["ENSRNOG00000004540",493,31.71490603,2501,161.469211,0.196414572,-2.348026125,0,0,"down","yes","Clec3b","protein_coding","chr8:122810149-122815835:+","gi|392342149|ref|XP_003754515.1|",962,{"v":3e-128,"d":"3.00E-128"},"PREDICTED: tetranectin [Rattus norvegicus]","gi|672023508|ref|XM_003754467.3|",949,0,"PREDICTED: Rattus norvegicus tetranectin-like (LOC100912012), mRNA","P43025",359,{"v":1e-123,"d":"1.00E-123"},"Tetranectin",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0001501|skeletal system development;GO:0001503|ossification;GO:0010756|positive regulation of plasminogen activation;GO:0030282|bone mineralization;GO:0071310|cellular response to organic substance;GO:0071560|cellular response to transforming growth factor beta stimulus;","GO:0001652|granular component;GO:0005615|extracellular space;GO:0005737|cytoplasm;","GO:0005509|calcium ion binding;GO:0008201|heparin binding;GO:0030246|carbohydrate binding;GO:0036143|kringle domain binding;","K17520","CLEC3B; C-type lectin domain family 3 member B"]
["ENSRNOG00000008680",476,30.62128858,2445,157.8537469,0.193985187,-2.365981606,0,0,"down","yes","Loxl1","protein_coding","chr8:58692593-58716356:-","gi|58865820|ref|NP_001012125.1|",2495,0,"lysyl oxidase homolog 1 precursor [Rattus norvegicus]","gi|58865819|ref|NM_001012125.1|",2450,0,"Rattus norvegicus lysyl oxidase-like 1 (Loxl1), mRNA","P97873",933,0,"Lysyl oxidase homolog 1",".",".",".",".","pfam01186","Lysyl_oxidase","Lysyl oxidase.","GO:0018057|peptidyl-lysine oxidation;GO:0030199|collagen fibril organization;GO:0032496|response to lipopolysaccharide;GO:0035904|aorta development;","GO:0001669|acrosomal vesicle;GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0031012|extracellular matrix;","GO:0003674|molecular_function;GO:0004720|protein-lysine 6-oxidase activity;GO:0005507|copper ion binding;GO:0016641|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor;","K14678","LOXL1; lysyl oxidase-like protein 1 [EC:1.4.3.-]"]
["ENSRNOG00000029996",534,34.35245399,2567,165.7302937,0.207279268,-2.270352268,0,0,"down","yes","AABR07054368.1","protein_coding","chr3:143138640-143140802:-","gi|62896605|dbj|BAD96243.1|",1815,0,"eukaryotic translation elongation factor 1 alpha 1 variant [Homo sapiens]","gi|672047760|ref|XR_591795.1|",1138,0,"PREDICTED: Rattus norvegicus elongation factor 1-alpha 1 pseudogene (LOC103691939), misc_RNA","P62630",702,0,"Elongation factor 1-alpha 1","SPCC794.09c",573,0,"COG5256","pfam03143","GTP_EFTU_D3","Elongation factor Tu C-terminal domain. Elongation factor Tu consists of three structural domains, this is the third domain. This domain adopts a beta barrel structure. This the third domain is involved in binding to both charged tRNA and binding to EF-Ts pfam00889.",".",".",".",".","."]
["ENSRNOG00000019638",2533,162.9489999,5982,386.2090445,0.421919171,-1.244961453,0,0,"down","yes","Lmna","protein_coding","chr2:173939751-173960423:-","gi|74220666|dbj|BAE31539.1|",2254,0,"unnamed protein product, partial [Mus musculus]","gi|612149767|ref|NM_001002016.2|",1908,0,"Rattus norvegicus lamin A/C (Lmna), mRNA","P48678",847,0,"Prelamin-A/C",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0006606|protein import into nucleus;GO:0006997|nucleus organization;GO:0006998|nuclear envelope organization;GO:0007283|spermatogenesis;GO:0007517|muscle organ development;GO:0008285|negative regulation of cell proliferation;GO:0009612|response to mechanical stimulus;GO:0010628|positive regulation of gene expression;GO:0030334|regulation of cell migration;GO:0030951|establishment or maintenance of microtubule cytoskeleton polarity;GO:0031647|regulation of protein stability;GO:0032204|regulation of telomere maintenance;GO:0034504|protein localization to nucleus;GO:0034613|cellular protein localization;GO:0045669|positive regulation of osteoblast differentiation;GO:0055015|ventricular cardiac muscle cell development;GO:0071456|cellular response to hypoxia;GO:0072201|negative regulation of mesenchymal cell proliferation;GO:0090201|negative regulation of release of cytochrome c from mitochondria;GO:0090343|positive regulation of cell aging;GO:0090398|cellular senescence;GO:1900114|positive regulation of histone H3-K9 trimethylation;GO:1900180|regulation of protein localization to nucleus;GO:1903243|negative regulation of cardiac muscle hypertrophy in response to stress;GO:1904178|negative regulation of adipose tissue development;GO:1990683|DNA double-strand break attachment to nuclear envelope;GO:2001237|negative regulation of extrinsic apoptotic signaling pathway;","GO:0005634|nucleus;GO:0005635|nuclear envelope;GO:0005638|lamin filament;GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0005882|intermediate filament;GO:0016363|nuclear matrix;GO:0016604|nuclear body;GO:0016607|nuclear speck;GO:0031965|nuclear membrane;GO:0035861|site of double-strand break;GO:0048471|perinuclear region of cytoplasm;","GO:0005515|protein binding;GO:0008157|protein phosphatase 1 binding;GO:0042802|identical protein binding;","K12641","LMNA; lamin A/C"]
["ENSRNOG00000024799",1177,75.71692574,3775,243.7210202,0.310670478,-1.686542943,0,0,"down","yes","Cd93","protein_coding","chr3:135891859-135898378:-","gi|21541989|sp|Q9ET61.1|C1QR1_RAT",3136,0,"RecName: Full=Complement component C1q receptor; AltName: Full=C1q/MBL/SPA receptor; Short=C1qR(p); Short=C1qRp; AltName: Full=Cell surface antigen AA4; AltName: Full=Complement component 1 q subcomponent receptor 1; AltName: CD_antigen=CD93; Flags: Precursor","gi|16758113|ref|NM_053383.1|",4732,0,"Rattus norvegicus CD93 molecule (Cd93), mRNA","Q9ET61",1212,0,"Complement component C1q receptor",".",".",".",".","pfam14670","FXa_inhibition","Coagulation Factor Xa inhibitory site. This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.","GO:0098609|cell-cell adhesion;","GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0031410|cytoplasmic vesicle;","GO:0001849|complement component C1q binding;GO:0005509|calcium ion binding;GO:0030246|carbohydrate binding;","K06702","CD93; CDW93 antigen"]
["ENSRNOG00000011774",311,20.00676628,2055,132.6746216,0.150795729,-2.729332528,0,0,"down","yes","Fblim1","protein_coding","chr5:153883960-153913757:-","gi|672054582|ref|XP_008762495.1|",1713,0,"PREDICTED: filamin-binding LIM protein 1 isoform X1 [Rattus norvegicus]","gi|672054585|ref|XM_008764275.1|",2858,0,"PREDICTED: Rattus norvegicus filamin binding LIM protein 1 (Fblim1), transcript variant X3, mRNA","Q71FD7",572,0,"Filamin-binding LIM protein 1",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.","GO:0000381|regulation of alternative mRNA splicing, via spliceosome;GO:0006397|mRNA processing;GO:0008150|biological_process;GO:0033623|regulation of integrin activation;GO:0098609|cell-cell adhesion;","GO:0001650|fibrillar center;GO:0001725|stress fiber;GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005925|focal adhesion;GO:0030054|cell junction;GO:0035770|ribonucleoprotein granule;GO:0071944|cell periphery;GO:1990904|ribonucleoprotein complex;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0003674|molecular_function;GO:0031005|filamin binding;GO:0046872|metal ion binding;GO:0097157|pre-mRNA intronic binding;","K24416","FBLIM1, FBLP1; filamin-binding LIM protein 1"]
["ENSRNOG00000016456",77,4.95344374,1437,92.77539232,0.053391784,-4.227238425,0,0,"down","yes","Il33","protein_coding","chr1:227721435-227736373:+","gi|62079057|ref|NP_001014188.1|",808,{"v":9e-96,"d":"9.00E-96"},"interleukin-33 [Rattus norvegicus]","gi|62079056|ref|NM_001014166.1|",2051,0,"Rattus norvegicus interleukin 33 (Il33), mRNA","Q66H70",315,{"v":3e-97,"d":"3.00E-97"},"Interleukin-33",".",".",".",".","pfam15095","IL33","Interleukin 33.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001819|positive regulation of cytokine production;GO:0002281|macrophage activation involved in immune response;GO:0002282|microglial cell activation involved in immune response;GO:0002638|negative regulation of immunoglobulin production;GO:0002639|positive regulation of immunoglobulin production;GO:0002686|negative regulation of leukocyte migration;GO:0002826|negative regulation of T-helper 1 type immune response;GO:0002830|positive regulation of type 2 immune response;GO:0010186|positive regulation of cellular defense response;GO:0010628|positive regulation of gene expression;GO:0032436|positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032689|negative regulation of interferon-gamma production;GO:0032722|positive regulation of chemokine production;GO:0032736|positive regulation of interleukin-13 production;GO:0032753|positive regulation of interleukin-4 production;GO:0032754|positive regulation of interleukin-5 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0038172|interleukin-33-mediated signaling pathway;GO:0042060|wound healing;GO:0043032|positive regulation of macrophage activation;GO:0045345|positive regulation of MHC class I biosynthetic process;GO:0045348|positive regulation of MHC class II biosynthetic process;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048714|positive regulation of oligodendrocyte differentiation;GO:0050729|positive regulation of inflammatory response;GO:0051607|defense response to virus;GO:0051770|positive regulation of nitric-oxide synthase biosynthetic process;GO:0051930|regulation of sensory perception of pain;GO:0061518|microglial cell proliferation;GO:0071260|cellular response to mechanical stimulus;GO:0097191|extrinsic apoptotic signaling pathway;GO:0120042|negative regulation of macrophage proliferation;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005694|chromosome;GO:0005737|cytoplasm;GO:0030133|transport vesicle;GO:0043231|intracellular membrane-bounded organelle;","GO:0002112|interleukin-33 receptor binding;GO:0005125|cytokine activity;GO:0005515|protein binding;","K12967","IL33; interleukin 33"]
["ENSRNOG00000053766",751,48.31215908,2978,192.2652181,0.251278726,-1.99263956,0,0,"down","yes","Ramp3","protein_coding","chr14:81527385-81544902:+","gi|31377486|ref|NP_064485.2|",645,{"v":1E-79,"d":"1.00E-79"},"receptor activity-modifying protein 3 precursor [Rattus norvegicus]","gi|298891943|emb|FQ220789.1|",1221,0,"Rattus norvegicus TL0ADA41YK17 mRNA sequence","Q9JJ73",253,{"v":4e-81,"d":"4.00E-81"},"Receptor activity-modifying protein 3",".",".",".",".","pfam04901","RAMP","Receptor activity modifying family. The calcitonin-receptor-like receptor can function as either a calcitonin-gene-related peptide or an adrenomedullin receptor. The receptors function is modified by receptor-activity-modifying protein or RAMP. RAMPs are single-transmembrane-domain proteins.","GO:0001921|positive regulation of receptor recycling;GO:0006816|calcium ion transport;GO:0006886|intracellular protein transport;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0010628|positive regulation of gene expression;GO:0010739|positive regulation of protein kinase A signaling;GO:0010942|positive regulation of cell death;GO:0015031|protein transport;GO:0031623|receptor internalization;GO:0032870|cellular response to hormone stimulus;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0038041|cross-receptor inhibition within G protein-coupled receptor heterodimer;GO:0051897|positive regulation of protein kinase B signaling;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071392|cellular response to estradiol stimulus;GO:0072659|protein localization to plasma membrane;GO:0086103|G protein-coupled receptor signaling pathway involved in heart process;GO:0097647|amylin receptor signaling pathway;GO:1903078|positive regulation of protein localization to plasma membrane;GO:1904645|response to amyloid-beta;GO:1905665|positive regulation of calcium ion import across plasma membrane;GO:1990410|adrenomedullin receptor signaling pathway;","GO:0005764|lysosome;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0043235|receptor complex;GO:0150058|amylin receptor complex 3;GO:1903143|adrenomedullin receptor complex;","GO:0001605|adrenomedullin receptor activity;GO:0001664|G protein-coupled receptor binding;GO:0015026|coreceptor activity;GO:0097643|amylin receptor activity;","K08449","RAMP3; receptor activity modifying protein 3"]
["ENSRNOG00000015655",1142,73.46536041,3693,238.4269477,0.30812524,-1.698411231,0,0,"down","yes","Ptgfrn","protein_coding","chr2:188469521-188544795:-","gi|9507007|ref|NP_062116.1|",4373,0,"prostaglandin F2 receptor negative regulator precursor [Rattus norvegicus]","gi|9507006|ref|NM_019243.1|",5772,0,"Rattus norvegicus prostaglandin F2 receptor inhibitor (Ptgfrn), mRNA","Q62786",1688,0,"Prostaglandin F2 receptor negative regulator",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0014905|myoblast fusion involved in skeletal muscle regeneration;GO:0017148|negative regulation of translation;GO:0034389|lipid droplet organization;","GO:0005789|endoplasmic reticulum membrane;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;","GO:0005515|protein binding;","K06729","PTGFRN, CD315; prostaglandin F2 receptor negative regulator"]
["ENSRNOG00000019244",3477,223.6769336,7338,473.7549262,0.472136375,-1.082724457,0,0,"down","yes","Mxra8","protein_coding","chr5:166449154-166453636:+","gi|564354514|ref|XP_006239636.1|",1685,0,"PREDICTED: matrix-remodeling-associated protein 8 isoform X1 [Rattus norvegicus]","gi|55742880|ref|NM_001007002.1|",2266,0,"Rattus norvegicus matrix-remodelling associated 8 (Mxra8), mRNA","Q5XI43",650,0,"Matrix remodeling-associated protein 8",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0007155|cell adhesion;GO:0060857|establishment of glial blood-brain barrier;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005923|bicellular tight junction;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0060170|ciliary membrane;",".","K24402","MXRA8; matrix remodeling-associated protein 8"]
["ENSRNOG00000017783",538,34.60977574,2535,163.6643142,0.211468064,-2.241488289,0,0,"down","yes","Sfrp1","protein_coding","chr16:68575763-68614286:-","gi|149057790|gb|EDM09033.1|",1304,{"v":3e-164,"d":"3.00E-164"},"secreted frizzled-related protein 1 [Rattus norvegicus]","gi|453040306|ref|NM_001276712.1|",3875,0,"Rattus norvegicus secreted frizzled-related protein 1 (Sfrp1), mRNA","Q8C4U3",505,{"v":3e-165,"d":"3.00E-165"},"Secreted frizzled-related protein 1",".",".",".",".","pfam01392","Fz","Fz domain. Also known as the CRD (cysteine rich domain), the C6 box in MuSK receptor. This domain of unknown function has been independently identified by several groups. The domain contains 10 conserved cysteines.","GO:0001649|osteoblast differentiation;GO:0001657|ureteric bud development;GO:0001756|somitogenesis;GO:0001843|neural tube closure;GO:0002244|hematopoietic progenitor cell differentiation;GO:0006508|proteolysis;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0008584|male gonad development;GO:0008585|female gonad development;GO:0009267|cellular response to starvation;GO:0009410|response to xenobiotic stimulus;GO:0009950|dorsal/ventral axis specification;GO:0009952|anterior/posterior pattern specification;GO:0010564|regulation of cell cycle process;GO:0010629|negative regulation of gene expression;GO:0010719|negative regulation of epithelial to mesenchymal transition;GO:0010975|regulation of neuron projection development;GO:0014034|neural crest cell fate commitment;GO:0014070|response to organic cyclic compound;GO:0021915|neural tube development;GO:0030097|hemopoiesis;GO:0030177|positive regulation of Wnt signaling pathway;GO:0030178|negative regulation of Wnt signaling pathway;GO:0030278|regulation of ossification;GO:0030279|negative regulation of ossification;GO:0030307|positive regulation of cell growth;GO:0030308|negative regulation of cell growth;GO:0030336|negative regulation of cell migration;GO:0030514|negative regulation of BMP signaling pathway;GO:0033689|negative regulation of osteoblast proliferation;GO:0035019|somatic stem cell population maintenance;GO:0035567|non-canonical Wnt signaling pathway;GO:0043065|positive regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0043508|negative regulation of JUN kinase activity;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0044345|stromal-epithelial cell signaling involved in prostate gland development;GO:0045578|negative regulation of B cell differentiation;GO:0045600|positive regulation of fat cell differentiation;GO:0045668|negative regulation of osteoblast differentiation;GO:0045671|negative regulation of osteoclast differentiation;GO:0045880|positive regulation of smoothened signaling pathway;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0046546|development of primary male sexual characteristics;GO:0046676|negative regulation of insulin secretion;GO:0046851|negative regulation of bone remodeling;GO:0048147|negative regulation of fibroblast proliferation;GO:0048546|digestive tract morphogenesis;GO:0050679|positive regulation of epithelial cell proliferation;GO:0050680|negative regulation of epithelial cell proliferation;GO:0050732|negative regulation of peptidyl-tyrosine phosphorylation;GO:0060070|canonical Wnt signaling pathway;GO:0060071|Wnt signaling pathway, planar cell polarity pathway;GO:0060218|hematopoietic stem cell differentiation;GO:0060346|bone trabecula formation;GO:0060527|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis;GO:0060687|regulation of branching involved in prostate gland morphogenesis;GO:0060766|negative regulation of androgen receptor signaling pathway;GO:0071305|cellular response to vitamin D;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071363|cellular response to growth factor stimulus;GO:0071380|cellular response to prostaglandin E stimulus;GO:0071391|cellular response to estrogen stimulus;GO:0071392|cellular response to estradiol stimulus;GO:0071456|cellular response to hypoxia;GO:0071481|cellular response to X-ray;GO:0071504|cellular response to heparin;GO:0071542|dopaminergic neuron differentiation;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0071773|cellular response to BMP stimulus;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0090175|regulation of establishment of planar polarity;GO:0090179|planar cell polarity pathway involved in neural tube closure;GO:0090244|Wnt signaling pathway involved in somitogenesis;GO:0090246|convergent extension involved in somitogenesis;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:1902043|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1904956|regulation of midbrain dopaminergic neuron differentiation;GO:2000041|negative regulation of planar cell polarity pathway involved in axis elongation;GO:2000052|positive regulation of non-canonical Wnt signaling pathway;GO:2000054|negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification;GO:2000080|negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation;GO:2000270|negative regulation of fibroblast apoptotic process;GO:2000271|positive regulation of fibroblast apoptotic process;GO:2001238|positive regulation of extrinsic apoptotic signaling pathway;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005829|cytosol;GO:0009986|cell surface;GO:0062023|collagen-containing extracellular matrix;","GO:0003674|molecular_function;GO:0004197|cysteine-type endopeptidase activity;GO:0005109|frizzled binding;GO:0008201|heparin binding;GO:0017147|Wnt-protein binding;GO:0042802|identical protein binding;","K02166","SFRP1; secreted frizzled-related protein 1"]
["ENSRNOG00000005871",79,5.082104617,1416,91.41959327,0.055590978,-4.169005421,{"v":1.2103e-305,"d":"1.21E-305"},{"v":2.3196e-304,"d":"2.32E-304"},"down","yes","Il1rn","protein_coding","chr3:7111550-7127445:+","gi|564339611|ref|XP_006233698.1|",857,{"v":3e-108,"d":"3.00E-108"},"PREDICTED: interleukin-1 receptor antagonist protein isoform X1 [Rattus norvegicus]","gi|672044714|ref|XM_006233636.2|",1947,0,"PREDICTED: Rattus norvegicus interleukin 1 receptor antagonist (Il1rn), transcript variant X1, mRNA","P25086",329,{"v":2E-107,"d":"2.00E-107"},"Interleukin-1 receptor antagonist protein",".",".",".",".","pfam00340","IL1","Interleukin-1 / 18. This family includes interleukin-1 and interleukin-18.","GO:0001660|fever generation;GO:0002437|inflammatory response to antigenic stimulus;GO:0002439|chronic inflammatory response to antigenic stimulus;GO:0006629|lipid metabolic process;GO:0006953|acute-phase response;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007165|signal transduction;GO:0007565|female pregnancy;GO:0007613|memory;GO:0009410|response to xenobiotic stimulus;GO:0009968|negative regulation of signal transduction;GO:0010243|response to organonitrogen compound;GO:0014050|negative regulation of glutamate secretion;GO:0014070|response to organic cyclic compound;GO:0014823|response to activity;GO:0019233|sensory perception of pain;GO:0019752|carboxylic acid metabolic process;GO:0030073|insulin secretion;GO:0030336|negative regulation of cell migration;GO:0032496|response to lipopolysaccharide;GO:0034115|negative regulation of heterotypic cell-cell adhesion;GO:0042594|response to starvation;GO:0043066|negative regulation of apoptotic process;GO:0043507|positive regulation of JUN kinase activity;GO:0045837|negative regulation of membrane potential;GO:0051384|response to glucocorticoid;GO:0070555|response to interleukin-1;GO:0070670|response to interleukin-4;GO:0071874|cellular response to norepinephrine stimulus;GO:2000660|negative regulation of interleukin-1-mediated signaling pathway;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0031982|vesicle;","GO:0005125|cytokine activity;GO:0005149|interleukin-1 receptor binding;GO:0005150|interleukin-1, type I receptor binding;GO:0005151|interleukin-1, type II receptor binding;GO:0005152|interleukin-1 receptor antagonist activity;GO:0045352|interleukin-1 type I receptor antagonist activity;GO:0045353|interleukin-1 type II receptor antagonist activity;","K05481","IL1RN, IL1F3; interleukin 1 receptor antagonist"]
["ENSRNOG00000031890",102,6.561704695,1479,95.48699043,0.068718311,-3.863161614,{"v":8.8546e-305,"d":"8.85E-305"},{"v":1.6913e-303,"d":"1.69E-303"},"down","yes","Ncam1","protein_coding","chr8:49865633-50166014:-","gi|564363529|ref|XP_006243050.1|",4997,0,"PREDICTED: neural cell adhesion molecule 1 isoform X5 [Rattus norvegicus]","gi|672061763|ref|XM_006242988.2|",3673,0,"PREDICTED: Rattus norvegicus neural cell adhesion molecule 1 (Ncam1), transcript variant X5, mRNA","P13595",1911,0,"Neural cell adhesion molecule 1",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0001928|regulation of exocyst assembly;GO:0007155|cell adhesion;GO:0007166|cell surface receptor signaling pathway;GO:0007413|axonal fasciculation;GO:0007420|brain development;GO:0007568|aging;GO:0007611|learning or memory;GO:0009410|response to xenobiotic stimulus;GO:0010035|response to inorganic substance;GO:0010288|response to lead ion;GO:0014012|peripheral nervous system axon regeneration;GO:0014823|response to activity;GO:0016338|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;GO:0021794|thalamus development;GO:0031100|animal organ regeneration;GO:0031175|neuron projection development;GO:0033555|multicellular organismal response to stress;GO:0034109|homotypic cell-cell adhesion;GO:0042220|response to cocaine;GO:0048666|neuron development;GO:0050804|modulation of chemical synaptic transmission;GO:0050850|positive regulation of calcium-mediated signaling;GO:0051930|regulation of sensory perception of pain;GO:0060045|positive regulation of cardiac muscle cell proliferation;GO:0060548|negative regulation of cell death;GO:0071219|cellular response to molecule of bacterial origin;GO:0071241|cellular response to inorganic substance;GO:0071679|commissural neuron axon guidance;GO:2001260|regulation of semaphorin-plexin signaling pathway;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0030426|growth cone;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098978|glutamatergic synapse;GO:0099055|integral component of postsynaptic membrane;GO:0099056|integral component of presynaptic membrane;","GO:0005104|fibroblast growth factor receptor binding;GO:0005515|protein binding;GO:0008092|cytoskeletal protein binding;GO:0008201|heparin binding;GO:0019902|phosphatase binding;GO:0030275|LRR domain binding;","K06491","NCAM, CD56; neural cell adhesion molecule"]
["ENSRNOG00000013668",457,29.39901025,2347,151.5266846,0.194018699,-2.365732391,{"v":8.9393e-305,"d":"8.94E-305"},{"v":1.7018e-303,"d":"1.70E-303"},"down","yes","Capg","protein_coding","chr4:104594753-104611856:+","gi|61556900|ref|NP_001013104.1|",1880,0,"macrophage-capping protein [Rattus norvegicus]","gi|672049919|ref|XM_006236666.2|",1187,0,"PREDICTED: Rattus norvegicus capping protein (actin filament), gelsolin-like (Capg), transcript variant X4, mRNA","Q6AYC4",728,0,"Macrophage-capping protein",".",".",".",".","pfam00626","Gelsolin","Gelsolin repeat.","GO:0007417|central nervous system development;GO:0008154|actin polymerization or depolymerization;GO:0030031|cell projection assembly;GO:0051014|actin filament severing;GO:0051016|barbed-end actin filament capping;GO:0071346|cellular response to interferon-gamma;","GO:0001726|ruffle;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005814|centriole;GO:0015629|actin cytoskeleton;GO:0030027|lamellipodium;GO:0042470|melanosome;GO:0045335|phagocytic vesicle;GO:0072686|mitotic spindle;GO:0090543|Flemming body;","GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0019904|protein domain specific binding;GO:0044877|protein-containing complex binding;GO:0051015|actin filament binding;","K10368","CAPG; capping protein (actin filament), gelsolin-like"]
["ENSRNOG00000011054",341,21.93667942,2089,134.8697248,0.16265088,-2.620149467,{"v":1.142E-304,"d":"1.14E-304"},{"v":2.1669e-303,"d":"2.17E-303"},"down","yes","Laptm5","protein_coding","chr5:143087759-143109807:+","gi|40254749|ref|NP_445990.2|",1091,{"v":3e-138,"d":"3.00E-138"},"lysosomal-associated transmembrane protein 5 [Rattus norvegicus]","gi|40254748|ref|NM_053538.2|",1978,0,"Rattus norvegicus lysosomal protein transmembrane 5 (Laptm5), mRNA","Q61168",400,{"v":2e-130,"d":"2.00E-130"},"Lysosomal-associated transmembrane protein 5",".",".",".",".","pfam03821","Mtp","Golgi 4-transmembrane spanning transporter.","GO:0002357|defense response to tumor cell;GO:0002720|positive regulation of cytokine production involved in immune response;GO:0006622|protein targeting to lysosome;GO:0006886|intracellular protein transport;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0012502|induction of programmed cell death;GO:0031398|positive regulation of protein ubiquitination;GO:0032689|negative regulation of interferon-gamma production;GO:0032703|negative regulation of interleukin-2 production;GO:0032735|positive regulation of interleukin-12 production;GO:0032755|positive regulation of interleukin-6 production;GO:0043410|positive regulation of MAPK cascade;GO:0046007|negative regulation of activated T cell proliferation;GO:0050860|negative regulation of T cell receptor signaling pathway;GO:0050868|negative regulation of T cell activation;GO:0050869|negative regulation of B cell activation;GO:0060907|positive regulation of macrophage cytokine production;GO:0061462|protein localization to lysosome;GO:0090160|Golgi to lysosome transport;GO:0097214|positive regulation of lysosomal membrane permeability;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1903052|positive regulation of proteolysis involved in cellular protein catabolic process;GO:1903265|positive regulation of tumor necrosis factor-mediated signaling pathway;GO:1904093|negative regulation of autophagic cell death;GO:1990830|cellular response to leukemia inhibitory factor;GO:2000060|positive regulation of ubiquitin-dependent protein catabolic process;GO:2000646|positive regulation of receptor catabolic process;","GO:0005764|lysosome;GO:0005765|lysosomal membrane;GO:0005829|cytosol;GO:0005887|integral component of plasma membrane;GO:0030133|transport vesicle;GO:0031410|cytoplasmic vesicle;GO:0032991|protein-containing complex;GO:0048471|perinuclear region of cytoplasm;","GO:0019899|enzyme binding;GO:0031625|ubiquitin protein ligase binding;GO:0140036|ubiquitin-dependent protein binding;","K12387","LAPTM; lysosomal-associated transmembrane protein"]
["ENSRNOG00000016143",2723,175.1717832,6173,398.5403597,0.43953336,-1.185955428,{"v":2.7964e-303,"d":"2.80E-303"},{"v":5.2536e-302,"d":"5.25E-302"},"down","yes","P3h3","protein_coding","chr4:157646243-157695509:-","gi|564348913|ref|XP_006237405.1|",3219,0,"PREDICTED: prolyl 3-hydroxylase 3 isoform X1 [Rattus norvegicus]","gi|672051009|ref|XM_008763280.1|",2905,0,"PREDICTED: Rattus norvegicus Cd4 molecule (Cd4), transcript variant X2, mRNA","Q8CG70",1169,0,"Prolyl 3-hydroxylase 3",".",".",".",".","pfam09191","CD4-extracel","CD4, extracellular. Members of this family adopt an immunoglobulin-like beta-sandwich, with seven strands in 2 beta sheets, in a Greek key topology. They are predominantly found in the extracellular portion of CD4 proteins, where they enable interaction with major histocompatibility complex class II antigens.","GO:0007186|G protein-coupled receptor signaling pathway;","GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;","K08440","GPR162; G protein-coupled receptor 162"]
["ENSRNOG00000020151",125,8.041304773,1537,99.23157829,0.081035744,-3.625297784,{"v":6.5332e-303,"d":"6.53E-303"},{"v":1.2234e-301,"d":"1.22E-301"},"down","yes","Cdh1","protein_coding","chr19:34492371-34561775:+","gi|13786164|ref|NP_112624.1|",3917,0,"cadherin-1 precursor [Rattus norvegicus]","gi|13786163|ref|NM_031334.1|",4097,0,"Rattus norvegicus cadherin 1 (Cdh1), mRNA","Q9R0T4",1513,0,"Cadherin-1",".",".",".",".","pfam01049","Cadherin_C","Cadherin cytoplasmic region. Cadherins are vital in cell-cell adhesion during tissue differentiation. Cadherins are linked to the cytoskeleton by catenins. Catenins bind to the cytoplasmic tail of the cadherin. Cadherins cluster to form foci of homophilic binding units. A key determinant to the strength of the binding that it is mediated by cadherins is the juxtamembrane region of the cadherin. This region induces clustering and also binds to the protein p120ctn.","GO:0001701|in utero embryonic development;GO:0001829|trophectodermal cell differentiation;GO:0003382|epithelial cell morphogenesis;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007416|synapse assembly;GO:0007566|embryo implantation;GO:0007605|sensory perception of sound;GO:0009410|response to xenobiotic stimulus;GO:0009636|response to toxic substance;GO:0010033|response to organic substance;GO:0010468|regulation of gene expression;GO:0010955|negative regulation of protein processing;GO:0016339|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0019538|protein metabolic process;GO:0021983|pituitary gland development;GO:0022408|negative regulation of cell-cell adhesion;GO:0022409|positive regulation of cell-cell adhesion;GO:0030336|negative regulation of cell migration;GO:0031175|neuron projection development;GO:0031532|actin cytoskeleton reorganization;GO:0032880|regulation of protein localization;GO:0033561|regulation of water loss via skin;GO:0034332|adherens junction organization;GO:0035847|uterine epithelium development;GO:0042307|positive regulation of protein import into nucleus;GO:0043281|regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0044331|cell-cell adhesion mediated by cadherin;GO:0045893|positive regulation of transcription, DNA-templated;GO:0046697|decidualization;GO:0050680|negative regulation of epithelial cell proliferation;GO:0060576|intestinal epithelial cell development;GO:0060662|salivary gland cavitation;GO:0060693|regulation of branching involved in salivary gland morphogenesis;GO:0070830|bicellular tight junction assembly;GO:0071230|cellular response to amino acid stimulus;GO:0071285|cellular response to lithium ion;GO:0071681|cellular response to indole-3-methanol;GO:0072659|protein localization to plasma membrane;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0090102|cochlea development;GO:0098609|cell-cell adhesion;GO:0098742|cell-cell adhesion via plasma-membrane adhesion molecules;GO:0099576|regulation of protein catabolic process at postsynapse, modulating synaptic transmission;GO:1903077|negative regulation of protein localization to plasma membrane;GO:2000008|regulation of protein localization to cell surface;GO:2001222|regulation of neuron migration;","GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005802|trans-Golgi network;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0005912|adherens junction;GO:0009898|cytoplasmic side of plasma membrane;GO:0009986|cell surface;GO:0015629|actin cytoskeleton;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016328|lateral plasma membrane;GO:0016342|catenin complex;GO:0016600|flotillin complex;GO:0030027|lamellipodium;GO:0030054|cell junction;GO:0030424|axon;GO:0030864|cortical actin cytoskeleton;GO:0033268|node of Ranvier;GO:0043219|lateral loop;GO:0043220|Schmidt-Lanterman incisure;GO:0043296|apical junction complex;GO:0043679|axon terminus;GO:0045177|apical part of cell;GO:0048471|perinuclear region of cytoplasm;GO:0071944|cell periphery;GO:0098794|postsynapse;GO:0098978|glutamatergic synapse;","GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0008013|beta-catenin binding;GO:0008092|cytoskeletal protein binding;GO:0019903|protein phosphatase binding;GO:0019904|protein domain specific binding;GO:0030506|ankyrin binding;GO:0032794|GTPase activating protein binding;GO:0042802|identical protein binding;GO:0045294|alpha-catenin binding;GO:0045295|gamma-catenin binding;GO:0045296|cadherin binding;GO:0050839|cell adhesion molecule binding;","K05689","CDH1, CDHE, CD324; cadherin 1, type 1, E-cadherin"]
["ENSRNOG00000021155",1086,69.86285587,3547,229.0009162,0.305076753,-1.712755846,{"v":8.9895e-303,"d":"8.99E-303"},{"v":1.6778E-301,"d":"1.68E-301"},"down","yes","Ctsk","protein_coding","chr2:183058569-183069550:+","gi|13928758|ref|NP_113748.1|",1774,0,"cathepsin K precursor [Rattus norvegicus]","gi|298906972|emb|FQ228691.1|",1421,0,"Rattus norvegicus TL0ADA52YL18 mRNA sequence","O35186",687,0,"Cathepsin K","AF1946_2",80.5,{"v":4e-16,"d":"4.00E-16"},"COG4870","pfam00112","Peptidase_C1","Papain family cysteine protease.","GO:0000422|autophagy of mitochondrion;GO:0001957|intramembranous ossification;GO:0006508|proteolysis;GO:0006590|thyroid hormone generation;GO:0006955|immune response;GO:0030574|collagen catabolic process;GO:0045453|bone resorption;GO:0051603|proteolysis involved in cellular protein catabolic process;GO:0061037|negative regulation of cartilage development;","GO:0005615|extracellular space;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0009897|external side of plasma membrane;GO:0016324|apical plasma membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0001968|fibronectin binding;GO:0004197|cysteine-type endopeptidase activity;GO:0005518|collagen binding;GO:0008234|cysteine-type peptidase activity;GO:0043394|proteoglycan binding;","K01371","CTSK; cathepsin K [EC:3.4.22.38]"]
["ENSRNOG00000027990",225,14.47434859,1783,115.1137958,0.125739478,-2.991490416,{"v":4.417e-298,"d":"4.42E-298"},{"v":8.2172e-297,"d":"8.22E-297"},"down","yes","Crip1","protein_coding","chr6:132226746-132234620:+","gi|148686610|gb|EDL18557.1|",578,{"v":2E-73,"d":"2.00E-73"},"cysteine-rich protein 1 (intestinal), isoform CRA_a [Mus musculus]","gi|349585430|ref|NM_001244867.1|",383,0,"Rattus norvegicus cysteine rich protein 1 (Crip1), transcript variant 1, mRNA","P63255",161,{"v":9e-50,"d":"9.00E-50"},"Cysteine-rich protein 1",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.","GO:0006955|immune response;GO:0008630|intrinsic apoptotic signaling pathway in response to DNA damage;GO:0010033|response to organic substance;GO:0010043|response to zinc ion;GO:0010468|regulation of gene expression;GO:0060741|prostate gland stromal morphogenesis;GO:0071236|cellular response to antibiotic;GO:0071493|cellular response to UV-B;","GO:0005737|cytoplasm;","GO:0008270|zinc ion binding;GO:0042277|peptide binding;","K24412","CRIP1, CRP1; cysteine-rich protein 1"]
["ENSRNOG00000002947",2020,129.9474851,5047,325.8437057,0.398803116,-1.326251413,{"v":2.0341E-295,"d":"2.03E-295"},{"v":3.7475e-294,"d":"3.75E-294"},"down","yes","Dpt","protein_coding","chr13:77123115-77151639:+","gi|564381450|ref|XP_006250215.1|",1026,{"v":5e-134,"d":"5.00E-134"},"PREDICTED: dermatopontin isoform X1 [Rattus norvegicus]","gi|564381449|ref|XM_006250153.1|",1720,0,"PREDICTED: Rattus norvegicus dermatopontin (Dpt), transcript variant X2, mRNA","P19427",371,{"v":1e-124,"d":"1.00E-124"},"Dermatopontin",".",".",".",".","pfam14704","DERM","Dermatopontin. Members of this family mediate cell adhesion via cell surface integrin binding. They also induce haemagglutination and aggregation of amebocytes.","GO:0008285|negative regulation of cell proliferation;GO:0030199|collagen fibril organization;","GO:0005576|extracellular region;",".","K25512","DPT; dermatopontin"]
["ENSRNOG00000030715",1134,72.9507169,3588,231.6479524,0.31492062,-1.666939869,{"v":8.2866e-295,"d":"8.29E-295"},{"v":1.5218e-293,"d":"1.52E-293"},"down","yes","Cfh","protein_coding","chr13:51511828-51613838:-","gi|77861917|ref|NP_569093.2|",6580,0,"complement factor H precursor [Rattus norvegicus]","gi|77861916|ref|NM_130409.2|",4250,0,"Rattus norvegicus complement factor H (Cfh), mRNA","P06909",2063,0,"Complement factor H",".",".",".",".","pfam00084","Sushi","Sushi domain (SCR repeat).","GO:0001525|angiogenesis;GO:0001780|neutrophil homeostasis;GO:0001822|kidney development;GO:0001905|activation of membrane attack complex;GO:0002021|response to dietary excess;GO:0002251|organ or tissue specific immune response;GO:0002434|immune complex clearance;GO:0003406|retinal pigment epithelium development;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0006956|complement activation;GO:0006957|complement activation, alternative pathway;GO:0007005|mitochondrion organization;GO:0007601|visual perception;GO:0008340|determination of adult lifespan;GO:0010467|gene expression;GO:0016064|immunoglobulin mediated immune response;GO:0030449|regulation of complement activation;GO:0032042|mitochondrial DNA metabolic process;GO:0032835|glomerulus development;GO:0034097|response to cytokine;GO:0035886|vascular smooth muscle cell differentiation;GO:0046034|ATP metabolic process;GO:0046530|photoreceptor cell differentiation;GO:0046548|retinal rod cell development;GO:0050905|neuromuscular process;GO:0051216|cartilage development;GO:0051640|organelle localization;GO:0060041|retina development in camera-type eye;GO:0060348|bone development;GO:0070301|cellular response to hydrogen peroxide;GO:0070487|monocyte aggregation;GO:0070527|platelet aggregation;GO:0071222|cellular response to lipopolysaccharide;GO:0071346|cellular response to interferon-gamma;GO:0090594|inflammatory response to wounding;GO:0097273|creatinine homeostasis;GO:0140053|mitochondrial gene expression;GO:1903659|regulation of complement-dependent cytotoxicity;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0030424|axon;GO:0043025|neuronal cell body;","GO:0001851|complement component C3b binding;GO:0003674|molecular_function;GO:0008201|heparin binding;GO:0042802|identical protein binding;GO:0043395|heparan sulfate proteoglycan binding;","K04004","CFH, HF1; complement factor H"]
["ENSRNOG00000070397",585,37.63330634,2565,165.60117,0.22725266,-2.137630915,{"v":2.1261e-294,"d":"2.13E-294"},{"v":3.892e-293,"d":"3.89E-293"},"down","yes","C4b","protein_coding","chr20:4197366-4211681:+","gi|50657362|ref|NP_001002805.1|",9057,0,"complement component 4, gene 2 precursor [Rattus norvegicus]","gi|259013548|ref|NM_001002805.2|",5351,0,"Rattus norvegicus complement component 4B (Chido blood group) (C4b), mRNA","P08649",3423,0,"Complement C4","TM0984",61.2,3e-08,"COG2373","pfam07678","A2M_comp","A-macroglobulin complement component. This family includes the complement components region of the alpha-2-macroglobulin family.",".",".",".",".","."]
["ENSRNOG00000011557",12,0.771965258,1271,82.05812362,0.009407542,-6.731966434,{"v":2.3719e-294,"d":"2.37E-294"},{"v":4.328e-293,"d":"4.33E-293"},"down","yes","S100a8","protein_coding","chr2:176167124-176167643:+","gi|281485600|ref|NP_446274.2|",470,{"v":2e-58,"d":"2.00E-58"},"protein S100-A8 [Rattus norvegicus]","gi|672042842|ref|XM_006232565.2|",355,0,"PREDICTED: Rattus norvegicus S100 calcium binding protein A8 (S100a8), transcript variant X1, mRNA","P50115",185,{"v":7e-60,"d":"7.00E-60"},"Protein S100-A8",".",".",".",".","pfam01023","S_100","S-100/ICaBP type calcium binding domain. The S-100 domain is a subfamily of the EF-hand calcium binding proteins.","GO:0002523|leukocyte migration involved in inflammatory response;GO:0002526|acute inflammatory response;GO:0002544|chronic inflammatory response;GO:0002793|positive regulation of peptide secretion;GO:0006914|autophagy;GO:0006915|apoptotic process;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006954|inflammatory response;GO:0010043|response to zinc ion;GO:0014002|astrocyte development;GO:0018119|peptidyl-cysteine S-nitrosylation;GO:0030593|neutrophil chemotaxis;GO:0032496|response to lipopolysaccharide;GO:0035425|autocrine signaling;GO:0042060|wound healing;GO:0045087|innate immune response;GO:0045471|response to ethanol;GO:0050729|positive regulation of inflammatory response;GO:0070488|neutrophil aggregation;GO:0098869|cellular oxidant detoxification;GO:2001244|positive regulation of intrinsic apoptotic signaling pathway;","GO:0005615|extracellular space;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0045111|intermediate filament cytoskeleton;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;GO:0008017|microtubule binding;GO:0008270|zinc ion binding;GO:0016209|antioxidant activity;GO:0035662|Toll-like receptor 4 binding;GO:0048306|calcium-dependent protein binding;GO:0050544|arachidonic acid binding;GO:0050786|RAGE receptor binding;","K21127","S100A8; protein S100-A8"]
["ENSRNOG00000008356",13,0.836295696,1261,81.41250503,0.010272325,-6.605093462,{"v":8.9764E-294,"d":"8.98E-294"},{"v":1.6327E-292,"d":"1.63E-292"},"down","yes","Myo5c","protein_coding","chr8:75989528-76066483:+","gi|564310298|ref|XP_006226541.1|",9405,0,"PREDICTED: unconventional myosin-Vc isoform X1 [Rattus norvegicus]","gi|672023077|ref|XM_006226479.2|",6637,0,"PREDICTED: Rattus norvegicus myosin VC (Myo5c), transcript variant X1, mRNA","Q9NQX4",3247,0,"Unconventional myosin-Vc","YOR326w",786,0,"COG5022","pfam00063","Myosin_head","Myosin head (motor domain).","GO:0007015|actin filament organization;GO:0030050|vesicle transport along actin filament;","GO:0005737|cytoplasm;GO:0015629|actin cytoskeleton;GO:0016459|myosin complex;GO:0031982|vesicle;","GO:0000146|microfilament motor activity;GO:0005524|ATP binding;GO:0051015|actin filament binding;","K10357","MYO5; myosin V"]
["ENSRNOG00000019129",11,0.70763482,1273,82.18724734,0.008610032,-6.859765705,{"v":7.3064e-293,"d":"7.31E-293"},{"v":1.3205e-291,"d":"1.32E-291"},"down","yes","Fcgbp","protein_coding","chr1:83372127-83413083:+","gi|695917199|ref|NP_001158129.2|",12945,0,"Fc fragment of IgG binding protein precursor [Rattus norvegicus]","gi|695917198|ref|NM_001164657.2|",7893,0,"Rattus norvegicus Fc fragment of IgG binding protein (Fcgbp), mRNA","Q9Y6R7",3427,0,"IgGFc-binding protein",".",".",".",".","pfam00094","VWD","von Willebrand factor type D domain. Luciferin-2-monooxygenase from Vargula hilgendorfii contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.",".","GO:0005615|extracellular space;GO:0031012|extracellular matrix;",".",".","."]
["ENSRNOG00000009892",53,3.409513224,1288,83.15567524,0.04100157,-4.608177043,{"v":8.1902e-292,"d":"8.19E-292"},{"v":1.4756E-290,"d":"1.48E-290"},"down","yes","Adamts15","protein_coding","chr8:29307865-29331249:-","gi|157819065|ref|NP_001100280.1|",4986,0,"A disintegrin and metalloproteinase with thrombospondin motifs 15 precursor [Rattus norvegicus]","gi|157819064|ref|NM_001106810.1|",6064,0,"Rattus norvegicus ADAM metallopeptidase with thrombospondin type 1 motif, 15 (Adamts15), mRNA","P59384",1909,0,"A disintegrin and metalloproteinase with thrombospondin motifs 15",".",".",".",".","pfam05986","ADAM_spacer1","ADAM-TS Spacer 1. This family represents the Spacer-1 region from the ADAM-TS family of metalloproteinases.","GO:0006508|proteolysis;GO:0007229|integrin-mediated signaling pathway;GO:0007520|myoblast fusion;GO:0022617|extracellular matrix disassembly;GO:0030198|extracellular matrix organization;","GO:0005615|extracellular space;GO:0009986|cell surface;GO:0031012|extracellular matrix;GO:0062023|collagen-containing extracellular matrix;","GO:0004175|endopeptidase activity;GO:0004222|metalloendopeptidase activity;GO:0008201|heparin binding;GO:0008270|zinc ion binding;GO:0050840|extracellular matrix binding;","K08629","ADAMTS15; a disintegrin and metalloproteinase with thrombospondin motifs 15 [EC:3.4.24.-]"]
["ENSRNOG00000008759",24,1.543930516,1223,78.95915436,0.019553534,-5.676426807,{"v":2.3373e-290,"d":"2.34E-290"},{"v":4.1977e-289,"d":"4.20E-289"},"down","yes","Csf3r","protein_coding","chr5:138301506-138317881:+","gi|672053656|ref|XP_008762225.1|",4381,0,"PREDICTED: granulocyte colony-stimulating factor receptor isoform X2 [Rattus norvegicus]","gi|672053663|ref|XM_008764007.1|",2113,0,"PREDICTED: Rattus norvegicus colony stimulating factor 3 receptor (granulocyte) (Csf3r), transcript variant X5, mRNA","P40223",1395,0,"Granulocyte colony-stimulating factor receptor",".",".",".",".","pfam06328","Lep_receptor_Ig","Ig-like C2-type domain. This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.","GO:0019221|cytokine-mediated signaling pathway;GO:0030593|neutrophil chemotaxis;GO:0045637|regulation of myeloid cell differentiation;GO:0097186|amelogenesis;","GO:0005575|cellular_component;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0043235|receptor complex;","GO:0003674|molecular_function;GO:0004896|cytokine receptor activity;GO:0019955|cytokine binding;GO:0051916|granulocyte colony-stimulating factor binding;","K05061","CSF3R, CD114; granulocyte colony-stimulating factor receptor"]
["ENSRNOG00000054957",319,20.52140978,1960,126.5412449,0.162171708,-2.624405945,{"v":1.7188E-286,"d":"1.72E-286"},{"v":3.0487E-285,"d":"3.05E-285"},"down","yes","Sfrp4","protein_coding","chr17:45234097-45330736:-","gi|149029250|gb|EDL84517.1|",1450,0,"secreted frizzled-related protein 4, isoform CRA_b [Rattus norvegicus]","gi|14279148|gb|AF220608.1|AF220608",2876,0,"Rattus norvegicus frizzled related protein (Frp) mRNA, complete cds","Q9JLS4",555,0,"Secreted frizzled-related protein 4",".",".",".",".","pfam01392","Fz","Fz domain. Also known as the CRD (cysteine rich domain), the C6 box in MuSK receptor. This domain of unknown function has been independently identified by several groups. The domain contains 10 conserved cysteines.","GO:0002092|positive regulation of receptor internalization;GO:0007565|female pregnancy;GO:0008285|negative regulation of cell proliferation;GO:0010628|positive regulation of gene expression;GO:0016055|Wnt signaling pathway;GO:0030154|cell differentiation;GO:0030510|regulation of BMP signaling pathway;GO:0032355|response to estradiol;GO:0035567|non-canonical Wnt signaling pathway;GO:0043065|positive regulation of apoptotic process;GO:0043433|negative regulation of DNA-binding transcription factor activity;GO:0043434|response to peptide hormone;GO:0045606|positive regulation of epidermal cell differentiation;GO:0046329|negative regulation of JNK cascade;GO:0046697|decidualization;GO:0051384|response to glucocorticoid;GO:0055062|phosphate ion homeostasis;GO:0060056|mammary gland involution;GO:0060070|canonical Wnt signaling pathway;GO:0060349|bone morphogenesis;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:1902174|positive regulation of keratinocyte apoptotic process;GO:2000051|negative regulation of non-canonical Wnt signaling pathway;GO:2000119|negative regulation of sodium-dependent phosphate transport;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0009986|cell surface;","GO:0017147|Wnt-protein binding;","K02185","SFRP4; secreted frizzled-related protein 4"]
["ENSRNOG00000007726",2564,164.9432435,5817,375.5563376,0.439197071,-1.187059662,{"v":2.4895E-286,"d":"2.49E-286"},{"v":4.4019e-285,"d":"4.40E-285"},"down","yes","Mcam","protein_coding","chr8:44479376-44487571:+","gi|77176452|ref|NP_076473.2|",3021,0,"cell surface glycoprotein MUC18 isoform 1 precursor [Rattus norvegicus]","gi|77176451|ref|NM_023983.3|",2893,0,"Rattus norvegicus melanoma cell adhesion molecule (Mcam), transcript variant 1, mRNA","Q9EPF2",1164,0,"Cell surface glycoprotein MUC18",".",".",".",".","pfam08205","C2-set_2","CD80-like C2-set immunoglobulin domain. These domains belong to the immunoglobulin superfamily.","GO:0001525|angiogenesis;GO:0003094|glomerular filtration;GO:0007155|cell adhesion;GO:0030335|positive regulation of cell migration;GO:0061042|vascular wound healing;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0043204|perikaryon;","GO:0003674|molecular_function;","K06534","MCAM, CD146; melanoma cell adhesion molecule"]
["ENSRNOG00000003666",14,0.900626135,1212,78.2489739,0.01150975,-6.440999681,{"v":2.7592E-284,"d":"2.76E-284"},{"v":4.8638e-283,"d":"4.86E-283"},"down","yes","Jchain","protein_coding","chr14:19538952-19546298:+","gi|149033720|gb|EDL88516.1|",844,{"v":2E-109,"d":"2.00E-109"},"immunoglobulin joining chain [Rattus norvegicus]","gi|67678280|gb|BC097960.1|",1237,0,"Rattus norvegicus immunoglobulin joining chain, mRNA (cDNA clone IMAGE:7384980)","P01592",305,{"v":1e-101,"d":"1.00E-101"},"Immunoglobulin J chain",".",".",".",".","pfam15097","Ig_J_chain","Immunoglobulin J chain.","GO:0001895|retina homeostasis;GO:0002250|adaptive immune response;GO:0003094|glomerular filtration;GO:0019731|antibacterial humoral response;GO:0045087|innate immune response;GO:0060267|positive regulation of respiratory burst;GO:0065003|protein-containing complex assembly;","GO:0005615|extracellular space;GO:0071748|monomeric IgA immunoglobulin complex;GO:0071750|dimeric IgA immunoglobulin complex;GO:0071751|secretory IgA immunoglobulin complex;GO:0071752|secretory dimeric IgA immunoglobulin complex;GO:0071756|pentameric IgM immunoglobulin complex;","GO:0003697|single-stranded DNA binding;GO:0019862|IgA binding;GO:0030674|protein binding, bridging;GO:0031210|phosphatidylcholine binding;GO:0034987|immunoglobulin receptor binding;GO:0042803|protein homodimerization activity;GO:0042834|peptidoglycan binding;",".","."]
["ENSRNOG00000066159",30,1.929913146,1192,76.95773671,0.025077572,-5.317458544,{"v":2.6408e-281,"d":"2.64E-281"},{"v":4.6124e-280,"d":"4.61E-280"},"down","yes","Cpm","protein_coding","chr7:53225696-53286220:+","gi|157821719|ref|NP_001101568.1|",2395,0,"carboxypeptidase M precursor [Rattus norvegicus]","gi|157821718|ref|NM_001108098.1|",5442,0,"Rattus norvegicus carboxypeptidase M (Cpm), mRNA","Q80V42",881,0,"Carboxypeptidase M","sll0236",70.5,{"v":3E-11,"d":"3.00E-11"},"COG2866","pfam00246","Peptidase_M14","Zinc carboxypeptidase.",".",".",".",".","."]
["ENSRNOG00000015406",209,13.44506158,1670,107.8183056,0.124701102,-3.003453875,{"v":2.1603e-280,"d":"2.16E-280"},{"v":3.7388e-279,"d":"3.74E-279"},"down","yes","Pgm5","protein_coding","chr1:222325643-222513437:-","gi|300794610|ref|NP_001178882.1|",2830,0,"phosphoglucomutase-like protein 5 [Rattus norvegicus]","gi|300794609|ref|NM_001191953.1|",1752,0,"Rattus norvegicus phosphoglucomutase 5 (Pgm5), mRNA","Q8BZF8",1088,0,"Phosphoglucomutase-like protein 5","SMc03925",496,{"v":2e-163,"d":"2.00E-163"},"COG0033","pfam02880","PGM_PMM_III","Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III.","GO:0005975|carbohydrate metabolic process;GO:0006006|glucose metabolic process;GO:0008150|biological_process;GO:0014706|striated muscle tissue development;GO:0030239|myofibril assembly;","GO:0001725|stress fiber;GO:0005575|cellular_component;GO:0005829|cytosol;GO:0005912|adherens junction;GO:0005914|spot adherens junction;GO:0005925|focal adhesion;GO:0009898|cytoplasmic side of plasma membrane;GO:0014704|intercalated disc;GO:0016010|dystrophin-associated glycoprotein complex;GO:0030018|Z disc;GO:0030055|cell-substrate junction;GO:0042383|sarcolemma;GO:0043034|costamere;","GO:0000287|magnesium ion binding;GO:0003674|molecular_function;","K15636","PGM5; phosphoglucomutase-like protein 5"]
["ENSRNOG00000010105",1987,127.8245807,4894,315.9657412,0.404552026,-1.305602848,{"v":1.014E-279,"d":"1.01E-279"},{"v":1.7443e-278,"d":"1.74E-278"},"down","yes","S100a11","protein_coding","chr2:179191715-179197044:+","gi|51854249|ref|NP_001004095.1|",518,{"v":9e-65,"d":"9.00E-65"},"protein S100-A11 [Rattus norvegicus]","gi|672043092|ref|XM_006232805.2|",394,0,"PREDICTED: Rattus norvegicus S100 calcium binding protein A11 (S100a11), transcript variant X1, mRNA","Q6B345",204,{"v":3e-66,"d":"3.00E-66"},"Protein S100-A11",".",".",".",".","pfam01023","S_100","S-100/ICaBP type calcium binding domain. The S-100 domain is a subfamily of the EF-hand calcium binding proteins.","GO:0014911|positive regulation of smooth muscle cell migration;GO:0042127|regulation of cell proliferation;","GO:0001726|ruffle;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0005509|calcium ion binding;GO:0042803|protein homodimerization activity;GO:0044548|S100 protein binding;GO:0048306|calcium-dependent protein binding;","K23765","S100A11_13, S100C; protein S100-A11/13"]
["ENSRNOG00000070432",9,0.578973944,1221,78.83003064,0.007344586,-7.089103103,{"v":3.4307e-277,"d":"3.43E-277"},{"v":5.8664e-276,"d":"5.87E-276"},"down","yes","ENSRNOG00000070432","protein_coding","chr12:34962484-34968130:-","gi|731222860|ref|XP_010625580.1|",507,{"v":3E-49,"d":"3.00E-49"},"PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC104864367 [Fukomys damarensis]","gi|315434303|gb|AC243170.5|",1211,0,"Rattus norvegicus Y Chr BAC RNAEX-212I22 (Amplicon Express Rat SHR-Akr BAC library) complete sequence","P26804",130,{"v":4e-68,"d":"4.00E-68"},"Envelope glycoprotein",".",".",".",".","pfam00429","TLV_coat","ENV polyprotein (coat polyprotein).",".",".",".",".","."]
["ENSRNOG00000000991",3354,215.7642897,6896,445.2185842,0.484625524,-1.045057705,{"v":1.8831e-276,"d":"1.88E-276"},{"v":3.2104e-275,"d":"3.21E-275"},"down","yes","Arpc1b","protein_coding","chr12:9480831-9495747:-","gi|9506405|ref|NP_062162.1|",1933,0,"actin-related protein 2/3 complex subunit 1B [Rattus norvegicus]","gi|42475955|ref|NM_019289.2|",1408,0,"Rattus norvegicus actin related protein 2/3 complex, subunit 1B (Arpc1b), mRNA","O88656",749,0,"Actin-related protein 2/3 complex subunit 1B",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.","GO:0032355|response to estradiol;GO:0034314|Arp2/3 complex-mediated actin nucleation;GO:0043627|response to estrogen;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005885|Arp2/3 protein complex;GO:0036284|tubulobulbar complex;","GO:0005200|structural constituent of cytoskeleton;GO:0044877|protein-containing complex binding;GO:0051015|actin filament binding;","K05757","ARPC1A_B; actin related protein 2/3 complex, subunit 1A/1B"]
["ENSRNOG00000010018",126,8.105635211,1429,92.25889745,0.087857491,-3.508690897,{"v":6.9852e-275,"d":"6.99E-275"},{"v":1.1873e-273,"d":"1.19E-273"},"down","yes","Clec4a3","protein_coding","chr4:156214718-156224817:+","gi|564348867|ref|XP_006237383.1|",1076,{"v":3e-143,"d":"3.00E-143"},"PREDICTED: C-type lectin domain family 4, member A3 isoform X1 [Rattus norvegicus]","gi|672050888|ref|XM_006237321.2|",1264,0,"PREDICTED: Rattus norvegicus C-type lectin domain family 4, member A3 (Clec4a3), transcript variant X1, mRNA","Q9QZ15",235,{"v":5e-73,"d":"5.00E-73"},"C-type lectin domain family 4 member A",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0001818|negative regulation of cytokine production;GO:0002470|plasmacytoid dendritic cell antigen processing and presentation;GO:0032720|negative regulation of tumor necrosis factor production;GO:0036037|CD8-positive, alpha-beta T cell activation;GO:0042590|antigen processing and presentation of exogenous peptide antigen via MHC class I;","GO:0016021|integral component of membrane;","GO:0005509|calcium ion binding;GO:0005537|mannose binding;GO:0030246|carbohydrate binding;","K10057","CLEC4A, CD367; C-type lectin domain family 4 member A"]
["ENSRNOG00000015310",207,13.3164007,1638,105.7523261,0.125920641,-2.989413303,{"v":7.8134e-274,"d":"7.81E-274"},{"v":1.3242E-272,"d":"1.32E-272"},"down","yes","Lrrc32","protein_coding","chr1:152786511-152798373:+","gi|281604174|ref|NP_001163905.1|",3275,0,"leucine-rich repeat-containing protein 32 precursor [Rattus norvegicus]","gi|281604173|ref|NM_001170434.1|",3948,0,"Rattus norvegicus leucine rich repeat containing 32 (Lrrc32), mRNA","Q5RF01",1016,0,"Leucine-rich repeat-containing protein 32","alr0124_1",74.3,{"v":1e-12,"d":"1.00E-12"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0001818|negative regulation of cytokine production;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0010628|positive regulation of gene expression;GO:0046007|negative regulation of activated T cell proliferation;GO:0062009|secondary palate development;GO:1901388|regulation of transforming growth factor beta activation;GO:1901398|regulation of transforming growth factor beta3 activation;","GO:0005654|nucleoplasm;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0050431|transforming growth factor beta binding;",".","."]
["ENSRNOG00000008246",1739,111.870632,4465,288.2687034,0.388077619,-1.365582862,{"v":1.7388E-273,"d":"1.74E-273"},{"v":2.9381e-272,"d":"2.94E-272"},"down","yes","Emilin1","protein_coding","chr6:25445298-25463698:-","gi|524946270|ref|XP_005073585.1|",3444,0,"PREDICTED: EMILIN-1 [Mesocricetus auratus]","gi|672055483|ref|XM_006239793.2|",3159,0,"PREDICTED: Rattus norvegicus elastin microfibril interfacer 1 (Emilin1), transcript variant X1, mRNA","Q99K41",1120,0,"EMILIN-1",".",".",".",".","pfam07546","EMI","EMI domain. The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.","GO:0003180|aortic valve morphogenesis;GO:0007160|cell-matrix adhesion;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010811|positive regulation of cell-substrate adhesion;GO:0016477|cell migration;GO:0016525|negative regulation of angiogenesis;GO:0030198|extracellular matrix organization;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030948|negative regulation of vascular endothelial growth factor receptor signaling pathway;GO:0032966|negative regulation of collagen biosynthetic process;GO:0048251|elastic fiber assembly;GO:0050866|negative regulation of cell activation;GO:0060394|negative regulation of pathway-restricted SMAD protein phosphorylation;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:1901203|positive regulation of extracellular matrix assembly;GO:1904027|negative regulation of collagen fibril organization;GO:1905522|negative regulation of macrophage migration;","GO:0005615|extracellular space;GO:0031012|extracellular matrix;GO:0034668|integrin alpha4-beta1 complex;GO:0062023|collagen-containing extracellular matrix;GO:1990971|EMILIN complex;","GO:0030023|extracellular matrix constituent conferring elasticity;GO:0042802|identical protein binding;GO:0098640|integrin binding involved in cell-matrix adhesion;","K24246","EMILIN; emilin"]
["ENSRNOG00000007679",230,14.79600078,1693,109.3032284,0.135366549,-2.885056826,{"v":2.5128e-273,"d":"2.51E-273"},{"v":4.2334e-272,"d":"4.23E-272"},"down","yes","Cyth4","protein_coding","chr7:110152272-110176741:+","gi|564361059|ref|XP_006242093.1|",2110,0,"PREDICTED: cytohesin-4 isoform X1 [Rattus norvegicus]","gi|672060229|ref|XM_006242031.2|",2681,0,"PREDICTED: Rattus norvegicus cytohesin 4 (Cyth4), transcript variant X1, mRNA","Q80YW0",791,0,"Cytohesin-4","SPAC30.01c",167,{"v":2E-41,"d":"2.00E-41"},"COG5307","pfam01369","Sec7","Sec7 domain. The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.","GO:0032012|regulation of ARF protein signal transduction;GO:0050790|regulation of catalytic activity;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0034451|centriolar satellite;GO:0045171|intercellular bridge;","GO:0005085|guanyl-nucleotide exchange factor activity;","K18441","CYTH; cytohesin"]
["ENSRNOG00000022392",99,6.36871338,1340,86.51289194,0.073615773,-3.763841285,{"v":1.5483E-271,"d":"1.55E-271"},{"v":2.6009e-270,"d":"2.60E-270"},"down","yes","Hspb8","protein_coding","chr12:40176532-40191185:+","gi|16758408|ref|NP_446064.1|",932,{"v":1E-119,"d":"1.00E-119"},"heat shock protein beta-8 [Rattus norvegicus]","gi|54262175|ref|NM_053612.2|",1771,0,"Rattus norvegicus heat shock protein family B (small) member 8 (Hspb8), mRNA","Q9EPX0",363,{"v":4e-121,"d":"4.00E-121"},"Heat shock protein beta-8",".",".",".",".","pfam00011","HSP20","Hsp20/alpha crystallin family.","GO:0034620|cellular response to unfolded protein;GO:1905337|positive regulation of aggrephagy;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016604|nuclear body;GO:0101031|chaperone complex;","GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;","K08879","HSPB8; heat shock protein beta-8"]
["ENSRNOG00000007350",146,9.392243975,1454,93.87294394,0.100052726,-3.321167614,{"v":1.7638e-267,"d":"1.76E-267"},{"v":2.9369e-266,"d":"2.94E-266"},"down","yes","Rac2","protein_coding","chr7:110116260-110128720:-","gi|537235276|gb|ERE85167.1|",846,{"v":9e-107,"d":"9.00E-107"},"ras-related C3 botulinum toxin substrate 1-like protein [Cricetulus griseus]","gi|672060205|ref|XM_006242028.2|",587,0,"PREDICTED: Rattus norvegicus ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) (Rac2), transcript variant X1, mRNA","Q05144",311,{"v":3e-101,"d":"3.00E-101"},"Ras-related C3 botulinum toxin substrate 2",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0006935|chemotaxis;GO:0007015|actin filament organization;GO:0007163|establishment or maintenance of cell polarity;GO:0007186|G protein-coupled receptor signaling pathway;GO:0008045|motor neuron axon guidance;GO:0008284|positive regulation of cell proliferation;GO:0008360|regulation of cell shape;GO:0010592|positive regulation of lamellipodium assembly;GO:0010810|regulation of cell-substrate adhesion;GO:0016601|Rac protein signal transduction;GO:0030031|cell projection assembly;GO:0030036|actin cytoskeleton organization;GO:0030865|cortical cytoskeleton organization;GO:0032956|regulation of actin cytoskeleton organization;GO:0042129|regulation of T cell proliferation;GO:0043304|regulation of mast cell degranulation;GO:0043652|engulfment of apoptotic cell;GO:0045453|bone resorption;GO:0050790|regulation of catalytic activity;GO:0060263|regulation of respiratory burst;GO:0060753|regulation of mast cell chemotaxis;GO:0071593|lymphocyte aggregation;GO:0090023|positive regulation of neutrophil chemotaxis;GO:1902622|regulation of neutrophil migration;GO:1903955|positive regulation of protein targeting to mitochondrion;","GO:0005635|nuclear envelope;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0005938|cell cortex;GO:0016020|membrane;GO:0030027|lamellipodium;GO:0031410|cytoplasmic vesicle;GO:0042995|cell projection;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0019887|protein kinase regulator activity;GO:0019901|protein kinase binding;","K07860","RAC2; Ras-related C3 botulinum toxin substrate 2"]
["ENSRNOG00000020560",0,0.032165219,2329,150.3645711,0.000213915,-12.19067554,{"v":6.488e-267,"d":"6.49E-267"},{"v":1.0709e-265,"d":"1.07E-265"},"down","yes","AABR07005821.1","protein_coding","chr1:185617294-185696478:+","gi|43429892|gb|AAS46613.1|",6182,0,"pancrin [Rattus norvegicus]","gi|46250739|ref|NM_022849.3|",3428,0,"Rattus norvegicus deleted in malignant brain tumors 1 (Dmbt1), mRNA","Q8CIZ5",2383,0,"Deleted in malignant brain tumors 1 protein",".",".",".",".","pfam00530","SRCR","Scavenger receptor cysteine-rich domain. These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.",".",".",".",".","."]
["ENSRNOG00000018414",441,28.36972324,2136,137.9041322,0.205720618,-2.281241705,{"v":7.3904E-266,"d":"7.39E-266"},{"v":1.1991e-264,"d":"1.20E-264"},"down","yes","Csf1r","protein_coding","chr18:54546659-54590415:+","gi|564393690|ref|XP_006254875.1|",5059,0,"PREDICTED: macrophage colony-stimulating factor 1 receptor isoform X1 [Rattus norvegicus]","gi|672083476|ref|XM_008772148.1|",3845,0,"PREDICTED: Rattus norvegicus colony stimulating factor 1 receptor (Csf1r), transcript variant X3, mRNA","P09581",1738,0,"Macrophage colony-stimulating factor 1 receptor",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001934|positive regulation of protein phosphorylation;GO:0002244|hematopoietic progenitor cell differentiation;GO:0002931|response to ischemia;GO:0006954|inflammatory response;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007275|multicellular organism development;GO:0007411|axon guidance;GO:0007519|skeletal muscle tissue development;GO:0008283|cell proliferation;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0008360|regulation of cell shape;GO:0010759|positive regulation of macrophage chemotaxis;GO:0014005|microglia development;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0019221|cytokine-mediated signaling pathway;GO:0021542|dentate gyrus development;GO:0021772|olfactory bulb development;GO:0021879|forebrain neuron differentiation;GO:0030097|hemopoiesis;GO:0030316|osteoclast differentiation;GO:0030335|positive regulation of cell migration;GO:0031529|ruffle organization;GO:0032722|positive regulation of chemokine production;GO:0032944|regulation of mononuclear cell proliferation;GO:0033674|positive regulation of kinase activity;GO:0036006|cellular response to macrophage colony-stimulating factor stimulus;GO:0038145|macrophage colony-stimulating factor signaling pathway;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0043066|negative regulation of apoptotic process;GO:0044794|positive regulation by host of viral process;GO:0045087|innate immune response;GO:0045124|regulation of bone resorption;GO:0045217|cell-cell junction maintenance;GO:0045672|positive regulation of osteoclast differentiation;GO:0046488|phosphatidylinositol metabolic process;GO:0046777|protein autophosphorylation;GO:0048015|phosphatidylinositol-mediated signaling;GO:0061098|positive regulation of protein tyrosine kinase activity;GO:0061518|microglial cell proliferation;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071345|cellular response to cytokine stimulus;GO:0071902|positive regulation of protein serine/threonine kinase activity;GO:0120041|positive regulation of macrophage proliferation;GO:1990138|neuron projection extension;GO:2000147|positive regulation of cell motility;GO:2000249|regulation of actin cytoskeleton reorganization;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0043235|receptor complex;GO:1990682|CSF1-CSF1R complex;","GO:0003674|molecular_function;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0005011|macrophage colony-stimulating factor receptor activity;GO:0005524|ATP binding;GO:0019903|protein phosphatase binding;GO:0019955|cytokine binding;GO:0042803|protein homodimerization activity;","K05090","CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]"]
["ENSRNOG00000029399",1199,77.13219538,3525,227.5805553,0.338922608,-1.560972218,{"v":1.0401e-263,"d":"1.04E-263"},{"v":1.6781e-262,"d":"1.68E-262"},"down","yes","Bcam","protein_coding","chr1:79415017-79429403:-","gi|149056706|gb|EDM08137.1|",2939,0,"basal cell adhesion molecule, isoform CRA_a [Rattus norvegicus]","gi|48976081|ref|NM_031752.2|",2288,0,"Rattus norvegicus basal cell adhesion molecule (Lutheran blood group) (Bcam), mRNA","Q9ESS6",1101,0,"Basal cell adhesion molecule",".",".",".",".","pfam08205","C2-set_2","CD80-like C2-set immunoglobulin domain. These domains belong to the immunoglobulin superfamily.","GO:0007155|cell adhesion;GO:0007160|cell-matrix adhesion;","GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0005055|laminin receptor activity;GO:0008022|protein C-terminus binding;GO:0043236|laminin binding;","K06578","LU, CD239; Lutheran blood group glycoprotein"]
["ENSRNOG00000031053",1986,127.7602502,4783,308.7993747,0.413732218,-1.273230788,{"v":4.7506e-263,"d":"4.75E-263"},{"v":7.6429e-262,"d":"7.64E-262"},"down","yes","Mt-nd4l","protein_coding","chrMT:9870-10166:+","gi|998247805|emb|CXH16302.1|",390,{"v":2E-46,"d":"2.00E-46"},"hypothetical protein PBK173_000516800 [Plasmodium berghei]","gi|755572967|gb|KP244683.1|",297,{"v":6E-153,"d":"6.00E-153"},"Rattus norvegicus isolate 115 mitochondrion, complete genome","P05507",136,{"v":7e-41,"d":"7.00E-41"},"NADH-ubiquinone oxidoreductase chain 4L",".",".",".",".","pfam00420","Oxidored_q2","NADH-ubiquinone/plastoquinone oxidoreductase chain 4L.","GO:0008150|biological_process;GO:0042773|ATP synthesis coupled electron transport;","GO:0005575|cellular_component;GO:0005743|mitochondrial inner membrane;GO:0005747|mitochondrial respiratory chain complex I;GO:0016021|integral component of membrane;GO:0030964|NADH dehydrogenase complex;GO:0070469|respiratory chain;","GO:0003674|molecular_function;GO:0008137|NADH dehydrogenase (ubiquinone) activity;","K03882","ND4L; NADH-ubiquinone oxidoreductase chain 4L [EC:7.1.1.2]"]
["ENSRNOG00000004411",169,10.87184405,1484,95.80979973,0.113473195,-3.13957656,{"v":7.1706e-260,"d":"7.17E-260"},{"v":1.1439e-258,"d":"1.14E-258"},"down","yes","Tspan8","protein_coding","chr7:51445074-51479356:+","gi|19424176|ref|NP_598210.1|",990,{"v":6e-130,"d":"6.00E-130"},"tetraspanin-8 [Rattus norvegicus]","gi|298913778|emb|FQ216712.1|",901,0,"Rattus norvegicus TL0ACA41YI07 mRNA sequence","Q8R3G9",329,{"v":3e-109,"d":"3.00E-109"},"Tetraspanin-8",".",".",".",".","pfam00335","Tetraspannin","Tetraspanin family.","GO:0007283|spermatogenesis;GO:0010468|regulation of gene expression;GO:0030195|negative regulation of blood coagulation;","GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;","GO:0005178|integrin binding;","K17349","TSPAN8; tetraspanin-8"]
["ENSRNOG00000002358",1646,105.8879013,4208,271.6763054,0.389757587,-1.359350988,{"v":4.3792e-256,"d":"4.38E-256"},{"v":6.815e-255,"d":"6.82E-255"},"down","yes","Scpep1","protein_coding","chr10:73703278-73732850:-","gi|19173736|ref|NP_596874.1|",2169,0,"retinoid-inducible serine carboxypeptidase precursor [Rattus norvegicus]","gi|19173735|ref|NM_133383.1|",1879,0,"Rattus norvegicus serine carboxypeptidase 1 (Scpep1), mRNA","Q920A6",839,0,"Retinoid-inducible serine carboxypeptidase","YGL203c",105,{"v":8e-23,"d":"8.00E-23"},"COG2939","pfam00450","Peptidase_S10","Serine carboxypeptidase.","GO:0006508|proteolysis;GO:0042573|retinoic acid metabolic process;GO:0045776|negative regulation of blood pressure;GO:0097746|regulation of blood vessel diameter;","GO:0005576|extracellular region;GO:0005829|cytosol;","GO:0004185|serine-type carboxypeptidase activity;","K09646","SCPEP1; serine carboxypeptidase 1 [EC:3.4.16.-]"]
["ENSRNOG00000043044",923,59.37699444,2994,193.2982078,0.307178194,-1.702852288,{"v":7.7598E-254,"d":"7.76E-254"},{"v":1.1914E-252,"d":"1.19E-252"},"down","yes","Cnn2","protein_coding","chr7:9712516-9719656:-","gi|6680952|ref|NP_031751.1|",1166,{"v":1E-167,"d":"1.00E-167"},"calponin-2 [Mus musculus]","gi|672021441|ref|XM_008776396.1|",1248,0,"PREDICTED: Rattus norvegicus calponin 2 (Cnn2), transcript variant X1, mRNA","Q08093",453,{"v":4e-169,"d":"4.00E-169"},"Calponin-2","ECU03g1150",82.8,{"v":5e-17,"d":"5.00E-17"},"COG5199","pfam00307","CH","Calponin homology (CH) domain. The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.","GO:0010628|positive regulation of gene expression;GO:0030097|hemopoiesis;GO:0030336|negative regulation of cell migration;GO:0031032|actomyosin structure organization;GO:0032970|regulation of actin filament-based process;GO:0042060|wound healing;GO:0042127|regulation of cell proliferation;GO:0050765|negative regulation of phagocytosis;GO:0071260|cellular response to mechanical stimulus;","GO:0001725|stress fiber;GO:0005856|cytoskeleton;","GO:0003779|actin binding;GO:0005516|calmodulin binding;",".","."]
["ENSRNOG00000012804",2324,149.5039383,5221,337.0774693,0.443529906,-1.172896709,{"v":2.2049e-252,"d":"2.20E-252"},{"v":3.367E-251,"d":"3.37E-251"},"down","yes","C1qc","protein_coding","chr5:149127415-149131017:-","gi|564353658|ref|XP_006239287.1|",1075,{"v":2e-142,"d":"2.00E-142"},"PREDICTED: complement C1q subcomponent subunit C isoform X1 [Rattus norvegicus]","gi|564353657|ref|XM_006239225.1|",1019,0,"PREDICTED: Rattus norvegicus complement component 1, q subcomponent, C chain (C1qc), transcript variant X1, mRNA","P31722",412,{"v":9e-142,"d":"9.00E-142"},"Complement C1q subcomponent subunit C",".",".",".",".","pfam00386","C1q","C1q domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.","GO:0006958|complement activation, classical pathway;GO:0008150|biological_process;GO:0030853|negative regulation of granulocyte differentiation;GO:0045087|innate immune response;GO:0045650|negative regulation of macrophage differentiation;GO:0098883|synapse pruning;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005581|collagen trimer;GO:0045202|synapse;GO:0098794|postsynapse;","GO:0003674|molecular_function;","K03988","C1QG; complement C1q subcomponent subunit C"]
["ENSRNOG00000049361",1080,69.47687324,3258,210.3425388,0.330303483,-1.598135911,{"v":2.6711e-252,"d":"2.67E-252"},{"v":4.0681e-251,"d":"4.07E-251"},"down","yes","Gas7","protein_coding","chr10:52152493-52383276:+","gi|664739356|ref|XP_008526967.1|",1794,0,"PREDICTED: growth arrest-specific protein 7 isoform X4 [Equus przewalskii]","gi|672068105|ref|XM_006246829.2|",7646,0,"PREDICTED: Rattus norvegicus growth arrest specific 7 (Gas7), transcript variant X4, mRNA","Q60780",677,0,"Growth arrest-specific protein 7",".",".",".",".","pfam00397","WW","WW domain. The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.","GO:0008360|regulation of cell shape;GO:0030041|actin filament polymerization;GO:0030182|neuron differentiation;GO:0048812|neuron projection morphogenesis;GO:0051017|actin filament bundle assembly;","GO:0001726|ruffle;GO:0005737|cytoplasm;GO:0005884|actin filament;GO:0005886|plasma membrane;","GO:0042802|identical protein binding;GO:0051015|actin filament binding;","K18618","GAS7; growth arrest-specific protein 7"]
["ENSRNOG00000012630",1712,110.1337102,4261,275.098084,0.400343429,-1.320689969,{"v":3.8592e-248,"d":"3.86E-248"},{"v":5.8003e-247,"d":"5.80E-247"},"down","yes","Rhoc","protein_coding","chr2:192287130-192295306:+","gi|564338187|ref|XP_006233136.1|",904,{"v":3e-116,"d":"3.00E-116"},"PREDICTED: rho-related GTP-binding protein RhoC isoform X1 [Rattus norvegicus]","gi|564338186|ref|XM_006233074.1|",589,0,"PREDICTED: Rattus norvegicus ras homolog family member C (Rhoc), transcript variant X1, mRNA","Q5RCK9",350,{"v":5E-117,"d":"5.00E-117"},"Rho-related GTP-binding protein RhoC",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0000281|mitotic cytokinesis;GO:0007015|actin filament organization;GO:0007163|establishment or maintenance of cell polarity;GO:0007264|small GTPase mediated signal transduction;GO:0008360|regulation of cell shape;GO:0016477|cell migration;GO:0030335|positive regulation of cell migration;GO:0030865|cortical cytoskeleton organization;GO:0031334|positive regulation of protein complex assembly;GO:0032956|regulation of actin cytoskeleton organization;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043297|apical junction assembly;GO:0044319|wound healing, spreading of cells;GO:0051496|positive regulation of stress fiber assembly;GO:0060193|positive regulation of lipase activity;GO:1902766|skeletal muscle satellite cell migration;","GO:0005634|nucleus;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0005938|cell cortex;GO:0016020|membrane;GO:0031410|cytoplasmic vesicle;GO:0032154|cleavage furrow;GO:0032420|stereocilium;GO:0042995|cell projection;GO:0043005|neuron projection;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0019901|protein kinase binding;","K07857","RHOC; Ras homolog gene family, member C"]
["ENSRNOG00000013415",115,7.398000391,1287,83.09111338,0.089034797,-3.489486907,{"v":1.0135E-246,"d":"1.01E-246"},{"v":1.5192E-245,"d":"1.52E-245"},"down","yes","Ptpn18","protein_coding","chr9:36672362-36690995:+","gi|61556976|ref|NP_001013129.1|",2183,0,"tyrosine-protein phosphatase non-receptor type 18 [Rattus norvegicus]","gi|1669507|gb|U69673.1|RNU69673",1368,0,"Rattus norvegicus protein tyrosine phosphatase 20 mRNA, complete cds","Q61152",781,0,"Tyrosine-protein phosphatase non-receptor type 18","SPAC19D5.01",140,{"v":1e-33,"d":"1.00E-33"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0001825|blastocyst formation;GO:0035335|peptidyl-tyrosine dephosphorylation;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0004725|protein tyrosine phosphatase activity;GO:0004726|non-membrane spanning protein tyrosine phosphatase activity;","K18024","PTPN12_18_22; tyrosine-protein phosphatase non-receptor type 12/18/22 [EC:3.1.3.48]"]
["ENSRNOG00000016164",120,7.719652582,1275,82.31637106,0.093780283,-3.414571555,{"v":2.9917e-240,"d":"2.99E-240"},{"v":4.4265e-239,"d":"4.43E-239"},"down","yes","Fcrl2","protein_coding","chr2:172694308-172707051:-","gi|157819017|ref|NP_001101172.1|",2587,0,"Fc receptor-like 2 precursor [Rattus norvegicus]","gi|157819016|ref|NM_001107702.1|",2252,0,"Rattus norvegicus Fc receptor-like 2 (Fcrl2), mRNA","Q96LA5",362,{"v":2e-114,"d":"2.00E-114"},"Fc receptor-like protein 2",".",".",".",".","pfam00530","SRCR","Scavenger receptor cysteine-rich domain. These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.","GO:0006897|endocytosis;GO:0007166|cell surface receptor signaling pathway;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;","GO:0003674|molecular_function;GO:0004888|transmembrane signaling receptor activity;GO:0005044|scavenger receptor activity;GO:0019903|protein phosphatase binding;GO:0035591|signaling adaptor activity;","K06727","FCRL, IRTA, CD307; Fc receptor-like protein"]
["ENSRNOG00000011346",657,42.26509789,2434,157.1435664,0.2689585,-1.894544512,{"v":3.9122e-239,"d":"3.91E-239"},{"v":5.7736e-238,"d":"5.77E-238"},"down","yes","Ehd2","protein_coding","chr1:76637482-76658783:-","gi|67846074|ref|NP_001020068.1|",2781,0,"EH domain-containing protein 2 [Rattus norvegicus]","gi|67846073|ref|NM_001024897.1|",2024,0,"Rattus norvegicus EH-domain containing 2 (Ehd2), mRNA","Q4V8H8",1075,0,"EH domain-containing protein 2",".",".",".",".","pfam00350","Dynamin_N","Dynamin family.","GO:0006897|endocytosis;GO:0016197|endosomal transport;GO:0030866|cortical actin cytoskeleton organization;GO:0032456|endocytic recycling;GO:0060271|cilium assembly;GO:0072659|protein localization to plasma membrane;GO:0097320|plasma membrane tubulation;GO:1901741|positive regulation of myoblast fusion;GO:2001137|positive regulation of endocytic recycling;","GO:0005737|cytoplasm;GO:0005769|early endosome;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005901|caveola;GO:0015630|microtubule cytoskeleton;GO:0016020|membrane;GO:0019898|extrinsic component of membrane;GO:0030139|endocytic vesicle;GO:0043231|intracellular membrane-bounded organelle;GO:0045171|intercellular bridge;GO:0048471|perinuclear region of cytoplasm;GO:0055038|recycling endosome membrane;","GO:0005509|calcium ion binding;GO:0005524|ATP binding;GO:0005525|GTP binding;GO:0016787|hydrolase activity;GO:0019904|protein domain specific binding;GO:0042802|identical protein binding;","K12469","EHD2; EH domain-containing protein 2"]
["ENSRNOG00000019138",71,4.567461111,1130,72.95490141,0.062606638,-3.997540557,{"v":1.8218E-238,"d":"1.82E-238"},{"v":2.6747e-237,"d":"2.67E-237"},"down","yes","Clec11a","protein_coding","chr1:94801496-94804633:-","gi|60223049|ref|NP_001012477.1|",1503,0,"C-type lectin domain family 11 member A precursor [Rattus norvegicus]","gi|60223048|ref|NM_001012459.1|",1920,0,"Rattus norvegicus C-type lectin domain family 11, member A (Clec11a), mRNA","O88201",583,0,"C-type lectin domain family 11 member A",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0001503|ossification;GO:0007165|signal transduction;GO:0008284|positive regulation of cell proliferation;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;","GO:0008083|growth factor activity;GO:0030246|carbohydrate binding;","K17521","CLEC11A; C-type lectin domain family 11 member A"]
["ENSRNOG00000000655",190,12.22278326,1449,93.55013464,0.130654898,-2.936166891,{"v":2.5708E-238,"d":"2.57E-238"},{"v":3.7647E-237,"d":"3.76E-237"},"down","yes","Ptprc","protein_coding","chr13:49596193-49708692:-","gi|56559|emb|CAA68272.1|",5958,0,"unnamed protein product [Rattus norvegicus]","gi|205146|gb|M18349.1|RATLCAG1",8442,0,"Rat leukocyte common antigen (L-CA) gene, exons 1 through 5","P04157",2296,0,"Receptor-type tyrosine-protein phosphatase C","SPAC19D5.01",135,{"v":8e-31,"d":"8.00E-31"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0001779|natural killer cell differentiation;GO:0001915|negative regulation of T cell mediated cytotoxicity;GO:0001916|positive regulation of T cell mediated cytotoxicity;GO:0001960|negative regulation of cytokine-mediated signaling pathway;GO:0002244|hematopoietic progenitor cell differentiation;GO:0002639|positive regulation of immunoglobulin production;GO:0002711|positive regulation of T cell mediated immunity;GO:0002923|regulation of humoral immune response mediated by circulating immunoglobulin;GO:0002925|positive regulation of humoral immune response mediated by circulating immunoglobulin;GO:0006469|negative regulation of protein kinase activity;GO:0006470|protein dephosphorylation;GO:0006933|negative regulation of cell adhesion involved in substrate-bound cell migration;GO:0007159|leukocyte cell-cell adhesion;GO:0010332|response to gamma radiation;GO:0010468|regulation of gene expression;GO:0016311|dephosphorylation;GO:0030183|B cell differentiation;GO:0030217|T cell differentiation;GO:0030890|positive regulation of B cell proliferation;GO:0031668|cellular response to extracellular stimulus;GO:0031953|negative regulation of protein autophosphorylation;GO:0032677|regulation of interleukin-8 production;GO:0032703|negative regulation of interleukin-2 production;GO:0032743|positive regulation of interleukin-2 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0034113|heterotypic cell-cell adhesion;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0035584|calcium-mediated signaling using intracellular calcium source;GO:0042098|T cell proliferation;GO:0042100|B cell proliferation;GO:0042102|positive regulation of T cell proliferation;GO:0043406|positive regulation of MAP kinase activity;GO:0043410|positive regulation of MAPK cascade;GO:0044770|cell cycle phase transition;GO:0044855|plasma membrane raft distribution;GO:0045059|positive thymic T cell selection;GO:0045060|negative thymic T cell selection;GO:0045582|positive regulation of T cell differentiation;GO:0045588|positive regulation of gamma-delta T cell differentiation;GO:0046425|regulation of JAK-STAT cascade;GO:0046641|positive regulation of alpha-beta T cell proliferation;GO:0048304|positive regulation of isotype switching to IgG isotypes;GO:0048539|bone marrow development;GO:0048864|stem cell development;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050732|negative regulation of peptidyl-tyrosine phosphorylation;GO:0050764|regulation of phagocytosis;GO:0050852|T cell receptor signaling pathway;GO:0050853|B cell receptor signaling pathway;GO:0050857|positive regulation of antigen receptor-mediated signaling pathway;GO:0051209|release of sequestered calcium ion into cytosol;GO:0051607|defense response to virus;GO:0051726|regulation of cell cycle;GO:0061097|regulation of protein tyrosine kinase activity;GO:0061099|negative regulation of protein tyrosine kinase activity;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:1903615|positive regulation of protein tyrosine phosphatase activity;GO:1905451|positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis;GO:2000473|positive regulation of hematopoietic stem cell migration;GO:2000648|positive regulation of stem cell proliferation;GO:2001236|regulation of extrinsic apoptotic signaling pathway;GO:2001238|positive regulation of extrinsic apoptotic signaling pathway;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005925|focal adhesion;GO:0009897|external side of plasma membrane;GO:0009898|cytoplasmic side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0032059|bleb;GO:0045121|membrane raft;GO:0071944|cell periphery;GO:0098857|membrane microdomain;","GO:0004725|protein tyrosine phosphatase activity;GO:0005001|transmembrane receptor protein tyrosine phosphatase activity;GO:0005102|signaling receptor binding;GO:0005515|protein binding;GO:0008201|heparin binding;GO:0019887|protein kinase regulator activity;GO:0019901|protein kinase binding;GO:0030506|ankyrin binding;GO:0030507|spectrin binding;GO:0043395|heparan sulfate proteoglycan binding;","K06478","PTPRC, CD45; receptor-type tyrosine-protein phosphatase C [EC:3.1.3.48]"]
["ENSRNOG00000013653",727,46.76822856,2541,164.0516854,0.28508228,-1.810549725,{"v":8.9167e-235,"d":"8.92E-235"},{"v":1.3024e-233,"d":"1.30E-233"},"down","yes","Pdlim7","protein_coding","chr17:9124649-9139811:+","gi|672081099|ref|XP_008769709.1|",2220,0,"PREDICTED: PDZ and LIM domain protein 7 isoform X1 [Rattus norvegicus]","gi|672081098|ref|XM_008771487.1|",1366,0,"PREDICTED: Rattus norvegicus PDZ and LIM domain 7 (Pdlim7), transcript variant X1, mRNA","Q9Z1Z9",805,0,"PDZ and LIM domain protein 7",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.","GO:0001503|ossification;GO:0007507|heart development;GO:0030036|actin cytoskeleton organization;GO:0030154|cell differentiation;GO:0045669|positive regulation of osteoblast differentiation;GO:0061061|muscle structure development;","GO:0001725|stress fiber;GO:0001726|ruffle;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005912|adherens junction;GO:0005925|focal adhesion;GO:0015629|actin cytoskeleton;GO:0030018|Z disc;GO:0031941|filamentous actin;","GO:0003779|actin binding;GO:0005515|protein binding;GO:0046872|metal ion binding;GO:0051371|muscle alpha-actinin binding;","K19867","PDLIM5_6_7; PDZ and LIM domain protein 5/6/7"]
["ENSRNOG00000002843",0,0.032165219,1926,124.3461417,0.000258675,-11.91657261,{"v":3.2634e-232,"d":"3.26E-232"},{"v":4.7185e-231,"d":"4.72E-231"},"down","yes","Cxcl6","protein_coding","chr14:17310426-17313093:-","gi|672075826|ref|XP_008768277.1|",517,{"v":2e-59,"d":"2.00E-59"},"PREDICTED: C-X-C motif chemokine 5 isoform X2 [Rattus norvegicus]","gi|672075825|ref|XM_008770055.1|",1378,0,"PREDICTED: Rattus norvegicus chemokine (C-X-C motif) ligand 6 (Cxcl6), transcript variant X3, mRNA","P97885",202,{"v":2e-60,"d":"2.00E-60"},"C-X-C motif chemokine 5",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0001776|leukocyte homeostasis;GO:0006952|defense response;GO:0006954|inflammatory response;GO:0007165|signal transduction;GO:0010332|response to gamma radiation;GO:0010976|positive regulation of neuron projection development;GO:0030593|neutrophil chemotaxis;GO:0030901|midbrain development;GO:0031100|animal organ regeneration;GO:0032496|response to lipopolysaccharide;GO:0032642|regulation of chemokine production;GO:0042119|neutrophil activation;GO:0046427|positive regulation of JAK-STAT cascade;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098|chemokine-mediated signaling pathway;GO:0070951|regulation of neutrophil mediated killing of gram-negative bacterium;GO:0071222|cellular response to lipopolysaccharide;","GO:0005615|extracellular space;","GO:0008009|chemokine activity;GO:0045236|CXCR chemokine receptor binding;","K05506","CXCL5_6, SCYB5_6; C-X-C motif chemokine 5/6"]
["ENSRNOG00000007613",256,16.46859218,1571,101.4266815,0.162369427,-2.622648085,{"v":6.8986e-230,"d":"6.90E-230"},{"v":9.85e-229,"d":"9.85E-229"},"down","yes","C1qtnf5","protein_coding","chr8:44451154-44453074:+","gi|880879631|ref|XP_012968263.1|",947,{"v":1e-122,"d":"1.00E-122"},"PREDICTED: complement C1q tumor necrosis factor-related protein 5 isoform X1 [Mesocricetus auratus]","gi|58865815|ref|NM_001012123.1|",1334,0,"Rattus norvegicus C1q and tumor necrosis factor related protein 5 (C1qtnf5), mRNA","Q5FVH0",349,{"v":1e-116,"d":"1.00E-116"},"Complement C1q tumor necrosis factor-related protein 5",".",".",".",".","pfam00386","C1q","C1q domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.","GO:0009306|protein secretion;GO:0048839|inner ear development;","GO:0005576|extracellular region;GO:0005581|collagen trimer;GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0005923|bicellular tight junction;GO:0016020|membrane;GO:0016324|apical plasma membrane;GO:0016328|lateral plasma membrane;GO:0030133|transport vesicle;GO:0032991|protein-containing complex;GO:0042995|cell projection;","GO:0042802|identical protein binding;","K24212","C1QTNF5; complement C1q and tumor necrosis factor-related protein 5"]
["ENSRNOG00000026953",34,2.187234898,992,64.04536478,0.034151338,-4.871914088,{"v":9.9836e-230,"d":"9.98E-230"},{"v":1.4219e-228,"d":"1.42E-228"},"down","yes","Gpr88","protein_coding","chr2:204191427-204199733:-","gi|914927195|ref|XP_013220370.1|",805,{"v":2E-92,"d":"2.00E-92"},"PREDICTED: probable G-protein coupled receptor 88 [Ictidomys tridecemlineatus]","gi|672044047|ref|XM_008761471.1|",4117,0,"PREDICTED: Rattus norvegicus G-protein coupled receptor 88 (Gpr88), transcript variant X1, mRNA","Q9ESP4",314,{"v":1e-93,"d":"1.00E-93"},"Probable G-protein coupled receptor 88",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0007602|phototransduction;GO:0007626|locomotory behavior;GO:0009584|detection of visible light;GO:0019228|neuronal action potential;GO:0050885|neuromuscular process controlling balance;GO:0061743|motor learning;GO:0071482|cellular response to light stimulus;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005929|cilium;","GO:0003774|motor activity;GO:0008020|G protein-coupled photoreceptor activity;","K08422","GPR88; G protein-coupled receptor 88"]
["ENSRNOG00000005809",274,17.62654006,1610,103.944594,0.169576304,-2.559993509,{"v":2.0963e-229,"d":"2.10E-229"},{"v":2.9782e-228,"d":"2.98E-228"},"down","yes","Arhgdib","protein_coding","chr4:169822952-169841658:-","gi|57527565|ref|NP_001009600.1|",1048,{"v":3e-139,"d":"3.00E-139"},"rho GDP-dissociation inhibitor 2 [Rattus norvegicus]","gi|672051435|ref|XM_006237562.2|",1276,0,"PREDICTED: Rattus norvegicus Rho, GDP dissociation inhibitor (GDI) beta (Arhgdib), transcript variant X2, mRNA","Q61599",394,{"v":4e-135,"d":"4.00E-135"},"Rho GDP-dissociation inhibitor 2",".",".",".",".","pfam02115","Rho_GDI","RHO protein GDP dissociation inhibitor.","GO:0007266|Rho protein signal transduction;GO:0035023|regulation of Rho protein signal transduction;GO:0050790|regulation of catalytic activity;GO:0071461|cellular response to redox state;GO:1901164|negative regulation of trophoblast cell migration;GO:2000249|regulation of actin cytoskeleton reorganization;","GO:0005829|cytosol;GO:0016020|membrane;","GO:0003924|GTPase activity;GO:0005094|Rho GDP-dissociation inhibitor activity;GO:0031267|small GTPase binding;","K12462","ARHGDI, RHOGDI; Rho GDP-dissociation inhibitor"]
["ENSRNOG00000006330",2,0.128660876,1255,81.02513387,1.587913E-3,-9.298652268,{"v":2.6369e-228,"d":"2.64E-228"},{"v":3.737E-227,"d":"3.74E-227"},"down","yes","Elf3","protein_coding","chr13:46690466-46695481:-","gi|568908113|ref|XP_006529187.1|",1738,0,"PREDICTED: ETS-related transcription factor Elf-3 isoform X1 [Mus musculus]","gi|672074111|ref|XM_006249881.2|",2046,0,"PREDICTED: Rattus norvegicus E74-like factor 3 (Elf3), transcript variant X1, mRNA","Q4V7E1",657,0,"ETS-related transcription factor Elf-3",".",".",".",".","pfam00178","Ets","Ets-domain.","GO:0001824|blastocyst development;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006366|transcription by RNA polymerase II;GO:0006954|inflammatory response;GO:0009653|anatomical structure morphogenesis;GO:0030154|cell differentiation;GO:0030198|extracellular matrix organization;GO:0030855|epithelial cell differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0060056|mammary gland involution;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005794|Golgi apparatus;GO:0005829|cytosol;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:1990837|sequence-specific double-stranded DNA binding;","K09429","K09429, ELF3; E74-like factor 3"]
["ENSRNOG00000055672",1,0.064330438,1505,97.16559878,0.00066207,-10.56072839,{"v":4.9246e-228,"d":"4.92E-228"},{"v":6.9447e-227,"d":"6.94E-227"},"down","yes","Gpx2","protein_coding","chr6:95493589-95496877:-","gi|145275176|ref|NP_899653.2|",1010,{"v":3e-135,"d":"3.00E-135"},"glutathione peroxidase 2 [Rattus norvegicus]","gi|145275175|ref|NM_183403.2|",1010,0,"Rattus norvegicus glutathione peroxidase 2 (Gpx2), mRNA","P83645",390,{"v":1E-135,"d":"1.00E-135"},"Glutathione peroxidase 2","slr1171",95.9,{"v":1E-22,"d":"1.00E-22"},"COG0386","pfam00255","GSHPx","Glutathione peroxidase.","GO:0001659|temperature homeostasis;GO:0002862|negative regulation of inflammatory response to antigenic stimulus;GO:0006979|response to oxidative stress;GO:0009609|response to symbiotic bacterium;GO:0051702|interaction with symbiont;GO:0098869|cellular oxidant detoxification;","GO:0005737|cytoplasm;","GO:0004601|peroxidase activity;GO:0004602|glutathione peroxidase activity;","K00432","gpx, btuE, bsaA; glutathione peroxidase [EC:1.11.1.9]"]
["ENSRNOG00000021260",5,0.321652191,1040,67.14433404,0.004790459,-7.705620337,{"v":1.0986E-225,"d":"1.10E-225"},{"v":1.5378E-224,"d":"1.54E-224"},"down","yes","Prnd","protein_coding","chr3:119213429-119218745:+","gi|564343103|ref|XP_006235118.1|",903,{"v":1e-110,"d":"1.00E-110"},"PREDICTED: prion-like protein doppel isoform X2 [Rattus norvegicus]","gi|672046747|ref|XM_006235058.2|",1759,0,"PREDICTED: Rattus norvegicus prion protein 2 (dublet) (Prnd), transcript variant X3, mRNA","Q9QUG3",319,{"v":6e-100,"d":"6.00E-100"},"Prion-like protein doppel",".",".",".",".","pfam00377","Prion","Prion/Doppel alpha-helical domain. The prion protein is thought to be the infectious agent that causes transmissible spongiform encephalopathies, such as scrapie and BSE. It is thought that the prion protein can exist in two different forms: one is the normal cellular protein, and the other is the infectious form which can change the normal prion protein into the infectious form. It has been found that the prion alpha-helical domain is also found in the Doppel protein.","GO:0006878|cellular copper ion homeostasis;GO:0007338|single fertilization;GO:0007340|acrosome reaction;GO:0051260|protein homooligomerization;","GO:0031362|anchored component of external side of plasma membrane;","GO:0005507|copper ion binding;",".","."]
["ENSRNOG00000046996",1544,99.32619656,3853,248.7568453,0.399290305,-1.324490053,{"v":1.4429E-225,"d":"1.44E-225"},{"v":2.0149e-224,"d":"2.01E-224"},"down","yes","Pea15","protein_coding","chr13:84654870-84667499:-","gi|537155461|gb|ERE72873.1|",647,{"v":5e-76,"d":"5.00E-76"},"astrocytic phosphoprotein PEA-15 [Cricetulus griseus]","gi|5640118|emb|AJ243949.1|",2227,0,"Rattus sp. mRNA for astrocytic phosphoprotein (PEA-15 gene)","Q5U318",245,{"v":4e-75,"d":"4.00E-75"},"Astrocytic phosphoprotein PEA-15",".",".",".",".","pfam01335","DED","Death effector domain.","GO:0000165|MAPK cascade;GO:0006915|apoptotic process;GO:0008643|carbohydrate transport;GO:0043278|response to morphine;GO:0046325|negative regulation of glucose import;GO:1902042|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1902043|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0003674|molecular_function;",".","."]
["ENSRNOG00000016488",473,30.42829726,2003,129.3174049,0.235299319,-2.087430952,{"v":1.3794e-223,"d":"1.38E-223"},{"v":1.8984e-222,"d":"1.90E-222"},"down","yes","Pltp","protein_coding","chr3:153574825-153592647:-","gi|564344297|ref|XP_006235597.1|",2524,0,"PREDICTED: phospholipid transfer protein isoform X1 [Rattus norvegicus]","gi|270483882|ref|NM_001168543.1|",2025,0,"Rattus norvegicus phospholipid transfer protein (Pltp), mRNA","P55065",854,0,"Phospholipid transfer protein",".",".",".",".","pfam02886","LBP_BPI_CETP_C","LBP / BPI / CETP family, C-terminal domain. The N and C terminal domains of the LBP/BPI/CETP family are structurally similar.","GO:0006629|lipid metabolic process;GO:0006869|lipid transport;GO:0008150|biological_process;GO:0010189|vitamin E biosynthetic process;GO:0010875|positive regulation of cholesterol efflux;GO:0015914|phospholipid transport;GO:0015918|sterol transport;GO:0030317|flagellated sperm motility;GO:0034375|high-density lipoprotein particle remodeling;GO:0035627|ceramide transport;GO:0046836|glycolipid transport;GO:0120009|intermembrane lipid transfer;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0034364|high-density lipoprotein particle;","GO:0003674|molecular_function;GO:0008035|high-density lipoprotein particle binding;GO:0008429|phosphatidylethanolamine binding;GO:0008525|phosphatidylcholine transporter activity;GO:0008526|phosphatidylinositol transporter activity;GO:0019992|diacylglycerol binding;GO:0030169|low-density lipoprotein particle binding;GO:0031210|phosphatidylcholine binding;GO:0034189|very-low-density lipoprotein particle binding;GO:0070300|phosphatidic acid binding;GO:0097001|ceramide binding;GO:0120014|intermembrane phospholipid transfer activity;GO:0120017|intermembrane ceramide transfer activity;GO:0120019|intermembrane phosphotidylcholine transfer activity;GO:0120020|intermembrane cholesterol transfer activity;GO:1901611|phosphatidylglycerol binding;GO:1904121|phosphatidylethanolamine transporter activity;GO:1990050|phosphatidic acid transporter activity;","K08761","PLTP; phospholipid transfer protein"]
["ENSRNOG00000019430",187,12.02979194,1379,89.03080446,0.135119434,-2.887692901,{"v":3.1485e-223,"d":"3.15E-223"},{"v":4.3123e-222,"d":"4.31E-222"},"down","yes","Coro1a","protein_coding","chr1:181295562-181300534:-","gi|18426834|ref|NP_569095.1|",2455,0,"coronin-1A [Rattus norvegicus]","gi|298889768|emb|FQ226941.1|",1610,0,"Rattus norvegicus TL0AEA15YO22 mRNA sequence","Q91ZN1",950,0,"Coronin-1A",".",".",".",".","pfam08954","DUF1900","Domain of unknown function (DUF1900). This domain is predominantly found in the structural protein coronin, and is duplicated in some sequences. It has no known function.","GO:0001845|phagolysosome assembly;GO:0006816|calcium ion transport;GO:0006909|phagocytosis;GO:0007015|actin filament organization;GO:0008064|regulation of actin polymerization or depolymerization;GO:0008150|biological_process;GO:0008360|regulation of cell shape;GO:0016477|cell migration;GO:0030036|actin cytoskeleton organization;GO:0030217|T cell differentiation;GO:0030335|positive regulation of cell migration;GO:0030595|leukocyte chemotaxis;GO:0030833|regulation of actin filament polymerization;GO:0031339|negative regulation of vesicle fusion;GO:0031589|cell-substrate adhesion;GO:0032796|uropod organization;GO:0032956|regulation of actin cytoskeleton organization;GO:0034097|response to cytokine;GO:0038180|nerve growth factor signaling pathway;GO:0042102|positive regulation of T cell proliferation;GO:0043029|T cell homeostasis;GO:0043320|natural killer cell degranulation;GO:0043524|negative regulation of neuron apoptotic process;GO:0048873|homeostasis of number of cells within a tissue;GO:0050870|positive regulation of T cell activation;GO:0050918|positive chemotaxis;GO:0051126|negative regulation of actin nucleation;GO:0051279|regulation of release of sequestered calcium ion into cytosol;GO:0061502|early endosome to recycling endosome transport;GO:0071353|cellular response to interleukin-4;","GO:0001772|immunological synapse;GO:0001891|phagocytic cup;GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005769|early endosome;GO:0005829|cytosol;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0015629|actin cytoskeleton;GO:0030027|lamellipodium;GO:0030424|axon;GO:0030670|phagocytic vesicle membrane;GO:0030864|cortical actin cytoskeleton;GO:0031252|cell leading edge;GO:0032426|stereocilium tip;GO:0032991|protein-containing complex;GO:0045202|synapse;GO:0045335|phagocytic vesicle;GO:0098978|glutamatergic synapse;","GO:0003674|molecular_function;GO:0003779|actin binding;GO:0003785|actin monomer binding;GO:0008022|protein C-terminus binding;GO:0008092|cytoskeletal protein binding;GO:0032036|myosin heavy chain binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0043548|phosphatidylinositol 3-kinase binding;GO:0051015|actin filament binding;","K13882","CORO1A; coronin-1A"]
["ENSRNOG00000004273",2535,163.0776608,5317,343.2754078,0.475063629,-1.073807339,{"v":3.3049e-223,"d":"3.30E-223"},{"v":4.5156e-222,"d":"4.52E-222"},"down","yes","Ifitm1","protein_coding","chr1:196067963-196069169:+","gi|157821317|ref|NP_001099784.1|",533,{"v":9e-66,"d":"9.00E-66"},"interferon-induced transmembrane protein 1 [Rattus norvegicus]","gi|157821316|ref|NM_001106314.1|",523,0,"Rattus norvegicus interferon induced transmembrane protein 1 (Ifitm1), mRNA","Q9D103",171,{"v":5E-52,"d":"5.00E-52"},"Interferon-induced transmembrane protein 1",".",".",".",".","pfam04505","Dispanin","Interferon-induced transmembrane protein. This family includes the human leukocyte antigen CD225, which is an interferon inducible transmembrane protein, and is associated with interferon induced cell growth suppression.","GO:0001756|somitogenesis;GO:0007507|heart development;GO:0009615|response to virus;GO:0009952|anterior/posterior pattern specification;GO:0034341|response to interferon-gamma;GO:0035455|response to interferon-alpha;GO:0035456|response to interferon-beta;GO:0045071|negative regulation of viral genome replication;GO:0046597|negative regulation of viral entry into host cell;GO:0051607|defense response to virus;GO:0060337|type I interferon signaling pathway;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;","K19831","IFITM1, CD225; interferon induced transmembrane protein 1"]
["ENSRNOG00000005580",145,9.327913537,1271,82.05812362,0.113674468,-3.137019844,{"v":1.0344E-222,"d":"1.03E-222"},{"v":1.41e-221,"d":"1.41E-221"},"down","yes","Itgb4","protein_coding","chr10:101206665-101243012:+","gi|589962289|ref|XP_006993703.1|",8925,0,"PREDICTED: integrin beta-4 [Peromyscus maniculatus bairdii]","gi|755537761|ref|XM_006532572.2|",4776,0,"PREDICTED: Mus musculus integrin beta 4 (Itgb4), transcript variant X6, mRNA","A2A863",3435,0,"Integrin beta-4",".",".",".",".","pfam00362","Integrin_beta","Integrin, beta chain. Integrins have been found in animals and their homologues have also been found in cyanobacteria, probably due to horizontal gene transfer. The sequences repeats have been trimmed due to an overlap with EGF.","GO:0006914|autophagy;GO:0007155|cell adhesion;GO:0007160|cell-matrix adhesion;GO:0007229|integrin-mediated signaling pathway;GO:0009611|response to wounding;GO:0016477|cell migration;GO:0022011|myelination in peripheral nervous system;GO:0031581|hemidesmosome assembly;GO:0032290|peripheral nervous system myelin formation;GO:0033627|cell adhesion mediated by integrin;GO:0035878|nail development;GO:0043589|skin morphogenesis;GO:0046847|filopodium assembly;GO:0048333|mesodermal cell differentiation;GO:0048870|cell motility;GO:0061450|trophoblast cell migration;","GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005925|focal adhesion;GO:0005938|cell cortex;GO:0008305|integrin complex;GO:0009925|basal plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030054|cell junction;GO:0030056|hemidesmosome;GO:0031252|cell leading edge;GO:0031965|nuclear membrane;GO:0043235|receptor complex;","GO:0001664|G protein-coupled receptor binding;GO:0005178|integrin binding;GO:0031994|insulin-like growth factor I binding;GO:0038132|neuregulin binding;GO:0050839|cell adhesion molecule binding;","K06525","ITGB4, CD104; integrin beta 4"]
["ENSRNOG00000005935",105,6.754696009,1164,75.15000464,0.089882842,-3.475810445,{"v":1.1768E-222,"d":"1.18E-222"},{"v":1.6002E-221,"d":"1.60E-221"},"down","yes","A3galt2","protein_coding","chr5:141107983-141115641:+","gi|19924055|ref|NP_612533.1|",1776,0,"alpha-1,3-galactosyltransferase 2 [Rattus norvegicus]","gi|40254730|ref|NM_138524.2|",1814,0,"Rattus norvegicus alpha 1,3-galactosyltransferase 2 (A3galt2), mRNA","A0A4Z3",688,0,"Alpha-1,3-galactosyltransferase 2",".",".",".",".","pfam03414","Glyco_transf_6","Glycosyltransferase family 6.","GO:0005975|carbohydrate metabolic process;GO:0006688|glycosphingolipid biosynthetic process;GO:0030259|lipid glycosylation;GO:0071287|cellular response to manganese ion;","GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;GO:0031982|vesicle;GO:0032580|Golgi cisterna membrane;","GO:0001962|alpha-1,3-galactosyltransferase activity;GO:0016757|transferase activity, transferring glycosyl groups;GO:0046872|metal ion binding;GO:0047276|N-acetyllactosaminide 3-alpha-galactosyltransferase activity;","K20736","A3GALT2; alpha-1,3-galactosyltransferase 2 [EC:2.4.1.87]"]
["ENSRNOG00000003120",286,18.39850532,1607,103.7509085,0.177333438,-2.495463496,{"v":1.4536e-222,"d":"1.45E-222"},{"v":1.972e-221,"d":"1.97E-221"},"down","yes","Prelp","protein_coding","chr13:45370533-45380270:-","gi|564380770|ref|XP_006249952.1|",1644,0,"PREDICTED: prolargin isoform X3 [Rattus norvegicus]","gi|672074152|ref|XM_006249891.2|",1417,0,"PREDICTED: Rattus norvegicus proline/arginine-rich end leucine-rich repeat protein (Prelp), transcript variant X3, mRNA","Q9EQP5",620,0,"Prolargin","alr0124_1",69.7,{"v":5e-12,"d":"5.00E-12"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0007569|cell aging;","GO:0005615|extracellular space;GO:0031012|extracellular matrix;GO:0062023|collagen-containing extracellular matrix;","GO:0005201|extracellular matrix structural constituent;GO:0008201|heparin binding;","K08125","PRELP; prolargin"]
["ENSRNOG00000016496",1272,81.82831737,3393,219.0583898,0.37354569,-1.420643379,{"v":4.5094e-221,"d":"4.51E-221"},{"v":6.103e-220,"d":"6.10E-220"},"down","yes","Ctsc","protein_coding","chr1:142028392-142060387:+","gi|8393218|ref|NP_058793.1|",2449,0,"dipeptidyl peptidase 1 precursor [Rattus norvegicus]","gi|298899550|emb|FQ218311.1|",2445,0,"Rattus norvegicus TL0ABA5YL12 mRNA sequence","P80067",919,0,"Dipeptidyl peptidase 1","AF1946_2",87.4,{"v":6e-18,"d":"6.00E-18"},"COG4870","pfam00112","Peptidase_C1","Papain family cysteine protease.","GO:0001913|T cell mediated cytotoxicity;GO:0006508|proteolysis;GO:0006915|apoptotic process;GO:0007568|aging;GO:0010033|response to organic substance;GO:0031642|negative regulation of myelination;GO:0051603|proteolysis involved in cellular protein catabolic process;GO:1903052|positive regulation of proteolysis involved in cellular protein catabolic process;GO:1903980|positive regulation of microglial cell activation;GO:2001235|positive regulation of apoptotic signaling pathway;","GO:0005615|extracellular space;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005813|centrosome;GO:0043231|intracellular membrane-bounded organelle;","GO:0004197|cysteine-type endopeptidase activity;GO:0004252|serine-type endopeptidase activity;GO:0008234|cysteine-type peptidase activity;GO:0008239|dipeptidyl-peptidase activity;GO:0016505|peptidase activator activity involved in apoptotic process;GO:0019902|phosphatase binding;GO:0031404|chloride ion binding;GO:0042802|identical protein binding;GO:0043621|protein self-association;GO:0051087|chaperone binding;","K01275","CTSC; cathepsin C [EC:3.4.14.1]"]
["ENSRNOG00000003720",212,13.6380529,1429,92.25889745,0.147823714,-2.758050366,{"v":9.6961e-221,"d":"9.70E-221"},{"v":1.3092E-219,"d":"1.31E-219"},"down","yes","Prrx1","protein_coding","chr13:75601706-75670866:-","gi|6755116|ref|NP_035257.1|",1207,{"v":2E-155,"d":"2.00E-155"},"paired mesoderm homeobox protein 1 isoform a [Mus musculus]","gi|62185741|gb|BC092372.1|",1634,0,"Mus musculus paired related homeobox 1, mRNA (cDNA clone MGC:90699 IMAGE:30533016), complete cds","P63014",467,{"v":5e-156,"d":"5.00E-156"},"Paired mesoderm homeobox protein 1","ECU03g1170",52.4,1e-06,"COG5576","pfam00046","Homeobox","Homeobox domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0002053|positive regulation of mesenchymal cell proliferation;GO:0006357|regulation of transcription by RNA polymerase II;GO:0030326|embryonic limb morphogenesis;GO:0042472|inner ear morphogenesis;GO:0042474|middle ear morphogenesis;GO:0045880|positive regulation of smoothened signaling pathway;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048664|neuron fate determination;GO:0048701|embryonic cranial skeleton morphogenesis;GO:0048704|embryonic skeletal system morphogenesis;GO:0048844|artery morphogenesis;GO:0051216|cartilage development;GO:0060021|roof of mouth development;GO:0070570|regulation of neuron projection regeneration;GO:0097150|neuronal stem cell population maintenance;GO:0100026|positive regulation of DNA repair by transcription from RNA polymerase II promoter;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;GO:0071837|HMG box domain binding;","K09329","PRRX, PMX; paired mesoderm homeobox protein"]
["ENSRNOG00000003098",28,1.801252269,935,60.36533878,0.029839181,-5.066648252,{"v":5.3454e-219,"d":"5.35E-219"},{"v":7.1665e-218,"d":"7.17E-218"},"down","yes","Prom1","protein_coding","chr14:66990160-67094527:+","gi|672076414|ref|XP_008768433.1|",4352,0,"PREDICTED: prominin-1 isoform X3 [Rattus norvegicus]","gi|672076413|ref|XM_008770211.1|",3723,0,"PREDICTED: Rattus norvegicus prominin 1 (Prom1), transcript variant X1, mRNA","O54990",1406,0,"Prominin-1",".",".",".",".","pfam05478","Prominin","Prominin. The prominins are an emerging family of proteins that among the multispan membrane proteins display a novel topology. Mouse prominin and human prominin (mouse)-like 1 (PROML1) are predicted to contain five membrane spanning domains, with an N-terminal domain exposed to the extracellular space followed by four, alternating small cytoplasmic and large extracellular, loops and a cytoplasmic C-terminal domain. The exact function of prominin is unknown although in humans defects in PROM1, the gene coding for prominin, cause retinal degeneration.","GO:0008150|biological_process;GO:0010842|retina layer formation;GO:0045494|photoreceptor cell maintenance;GO:0060042|retina morphogenesis in camera-type eye;GO:0060219|camera-type eye photoreceptor cell differentiation;GO:0072112|glomerular visceral epithelial cell differentiation;GO:0072139|glomerular parietal epithelial cell differentiation;GO:2000768|positive regulation of nephron tubule epithelial cell differentiation;","GO:0001750|photoreceptor outer segment;GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005783|endoplasmic reticulum;GO:0005793|endoplasmic reticulum-Golgi intermediate compartment;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005902|microvillus;GO:0005903|brush border;GO:0005929|cilium;GO:0009986|cell surface;GO:0016324|apical plasma membrane;GO:0031528|microvillus membrane;GO:0032420|stereocilium;GO:0042622|photoreceptor outer segment membrane;GO:0042995|cell projection;GO:0070062|extracellular exosome;GO:0071914|prominosome;","GO:0003674|molecular_function;GO:0015485|cholesterol binding;GO:0042805|actinin binding;GO:0045296|cadherin binding;","K06532","PROM1, CD133; prominin 1"]
["ENSRNOG00000018384",472,30.36396682,1973,127.3805491,0.238372083,-2.068712811,{"v":9.0673e-218,"d":"9.07E-218"},{"v":1.2071E-216,"d":"1.21E-216"},"down","yes","Adam12","protein_coding","chr1:188686989-189020667:-","gi|149061352|gb|EDM11775.1|",4450,0,"rCG47941, isoform CRA_a [Rattus norvegicus]","gi|672038793|ref|XM_008759968.1|",7144,0,"PREDICTED: Rattus norvegicus ADAM metallopeptidase domain 12 (Adam12), transcript variant X2, mRNA","Q61824",1623,0,"Disintegrin and metalloproteinase domain-containing protein 12",".",".",".",".","pfam01421","Reprolysin","Reprolysin (M12B) family zinc metalloprotease. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as human ADAM8 and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.","GO:0006508|proteolysis;GO:0008150|biological_process;GO:0045766|positive regulation of angiogenesis;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0004222|metalloendopeptidase activity;GO:0017124|SH3 domain binding;","K06835","ADAM12; disintegrin and metalloproteinase domain-containing protein 12 [EC:3.4.24.-]"]
["ENSRNOG00000033143",2353,151.369521,5006,323.1966694,0.468351117,-1.09433759,{"v":8.9486e-217,"d":"8.95E-217"},{"v":1.1858e-215,"d":"1.19E-215"},"down","yes","Cep295nl","protein_coding","chr10:103531505-103590611:-","gi|564375434|ref|XP_006247876.1|",2458,0,"PREDICTED: differential display clone 8 isoform X3 [Rattus norvegicus]","gi|672069869|ref|XM_008768387.1|",1685,0,"PREDICTED: Rattus norvegicus differential display clone 8 (Ddc8), transcript variant X7, mRNA","Q497N6",692,0,"CEP295 N-terminal-like protein",".",".",".",".","pfam00965","TIMP","Tissue inhibitor of metalloproteinase. Members of this family are common in extracellular regions of vertebrate species","GO:0046599|regulation of centriole replication;","GO:0005813|centrosome;GO:0005814|centriole;GO:0005829|cytosol;GO:0031514|motile cilium;","GO:0008017|microtubule binding;",".","."]
["ENSRNOG00000007302",1506,96.88163991,3735,241.1385458,0.401767538,-1.315567092,{"v":1.7805e-216,"d":"1.78E-216"},{"v":2.354E-215,"d":"2.35E-215"},"down","yes","Fbn1","protein_coding","chr3:112554925-112750889:-","gi|564342789|ref|XP_006234997.1|",14245,0,"PREDICTED: fibrillin-1 isoform X1 [Rattus norvegicus]","gi|672046994|ref|XM_006234935.2|",9231,0,"PREDICTED: Rattus norvegicus fibrillin 1 (Fbn1), transcript variant X1, mRNA","Q61554",4756,0,"Fibrillin-1",".",".",".",".","pfam06247","Plasmod_Pvs28","Plasmodium ookinete surface protein Pvs28. This family consists of several ookinete surface protein (Pvs28) from several species of Plasmodium. Pvs25 and Pvs28 are expressed on the surface of ookinetes. These proteins are potential candidates for vaccine and induce antibodies that block the infectivity of Plasmodium vivax in immunised animals.","GO:0001501|skeletal system development;GO:0001656|metanephros development;GO:0001822|kidney development;GO:0006006|glucose metabolic process;GO:0007507|heart development;GO:0009653|anatomical structure morphogenesis;GO:0010737|protein kinase A signaling;GO:0033627|cell adhesion mediated by integrin;GO:0034199|activation of protein kinase A activity;GO:0035582|sequestering of BMP in extracellular matrix;GO:0035583|sequestering of TGFbeta in extracellular matrix;GO:0042593|glucose homeostasis;GO:0043010|camera-type eye development;GO:0045671|negative regulation of osteoclast differentiation;GO:0048048|embryonic eye morphogenesis;GO:0048050|post-embryonic eye morphogenesis;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:1990314|cellular response to insulin-like growth factor stimulus;GO:2001205|negative regulation of osteoclast development;","GO:0001527|microfibril;GO:0005576|extracellular region;GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0031012|extracellular matrix;GO:0062023|collagen-containing extracellular matrix;","GO:0003674|molecular_function;GO:0005178|integrin binding;GO:0005179|hormone activity;GO:0005201|extracellular matrix structural constituent;GO:0005509|calcium ion binding;GO:0008201|heparin binding;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;","K06825","FBN1; fibrillin 1"]
["ENSRNOG00000032825",758,48.76247214,2500,161.4046491,0.302113182,-1.726838961,{"v":1.7874e-216,"d":"1.79E-216"},{"v":2.3575e-215,"d":"2.36E-215"},"down","yes","Rpl30","protein_coding","chr10:36831500-36831990:-","gi|664777237|ref|XP_008507911.1|",610,{"v":5e-78,"d":"5.00E-78"},"PREDICTED: 60S ribosomal protein L30-like [Equus przewalskii]","gi|672024756|ref|XM_003752328.3|",487,0,"PREDICTED: Rattus norvegicus ribosomal protein L30-like (LOC100362027), mRNA","P62890",236,{"v":1E-78,"d":"1.00E-78"},"60S ribosomal protein L30","SPAC9G1.03c",153,{"v":5e-47,"d":"5.00E-47"},"COG1911","pfam01248","Ribosomal_L7Ae","Ribosomal protein L7Ae/L30e/S12e/Gadd45 family. This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118.",".","GO:0005829|cytosol;",".","K02908","RP-L30e, RPL30; large subunit ribosomal protein L30e"]
["ENSRNOG00000001989",451,29.01302762,1913,123.5068375,0.234910295,-2.089818154,{"v":6.0702e-214,"d":"6.07E-214"},{"v":7.9333e-213,"d":"7.93E-213"},"down","yes","Alcam","protein_coding","chr11:48336169-48537954:+","gi|149060362|gb|EDM11076.1|",2935,0,"activated leukocyte cell adhesion molecule [Rattus norvegicus]","gi|158937321|ref|NM_009655.2|",3536,0,"Mus musculus activated leukocyte cell adhesion molecule (Alcam), mRNA","O35112",1132,0,"CD166 antigen",".",".",".",".","pfam08205","C2-set_2","CD80-like C2-set immunoglobulin domain. These domains belong to the immunoglobulin superfamily.","GO:0002250|adaptive immune response;GO:0007155|cell adhesion;GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007411|axon guidance;GO:0008045|motor neuron axon guidance;GO:0031290|retinal ganglion cell axon guidance;GO:0048846|axon extension involved in axon guidance;GO:1990138|neuron projection extension;","GO:0001772|immunological synapse;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0031226|intrinsic component of plasma membrane;GO:0043025|neuronal cell body;","GO:0042802|identical protein binding;","K06547","ALCAM, CD166; activated leukocyte cell adhesion molecule"]
["ENSRNOG00000024382",68,4.374469797,1021,65.91765871,0.066362639,-3.913484929,{"v":7.8648e-213,"d":"7.86E-213"},{"v":1.0186e-211,"d":"1.02E-211"},"down","yes","Fcgr3a","protein_coding","chr13:83249872-83259921:+","gi|672074776|ref|XP_008767961.1|",1276,{"v":3e-173,"d":"3.00E-173"},"PREDICTED: Fc fragment of IgG, low affinity IIIa, receptor isoform X1 [Rattus norvegicus]","gi|672074775|ref|XM_008769739.1|",1111,0,"PREDICTED: Rattus norvegicus Fc fragment of IgG, low affinity IIIa, receptor (Fcgr3a), transcript variant X1, mRNA","A0A0B4J1G0",409,{"v":1e-140,"d":"1.00E-140"},"Low affinity immunoglobulin gamma Fc region receptor IV",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0007166|cell surface receptor signaling pathway;GO:0038094|Fc-gamma receptor signaling pathway;GO:0038095|Fc-epsilon receptor signaling pathway;GO:0042060|wound healing;GO:0042119|neutrophil activation;GO:0045780|positive regulation of bone resorption;GO:0050776|regulation of immune response;GO:0051930|regulation of sensory perception of pain;GO:0071222|cellular response to lipopolysaccharide;","GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;","GO:0003674|molecular_function;GO:0004888|transmembrane signaling receptor activity;GO:0019767|IgE receptor activity;GO:0019770|IgG receptor activity;","K06463","FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III"]
["ENSRNOG00000002461",2600,167.2591393,5327,343.9210264,0.486330077,-1.039992277,{"v":2.4266e-212,"d":"2.43E-212"},{"v":3.1356E-211,"d":"3.14E-211"},"down","yes","Nid1","protein_coding","chr17:86085077-86158267:+","gi|109505096|ref|XP_213954.4|",6441,0,"PREDICTED: nidogen-1 isoform X2 [Rattus norvegicus]","gi|672082653|ref|XM_213954.8|",5858,0,"PREDICTED: Rattus norvegicus nidogen 1 (Nid1), transcript variant X2, mRNA","P10493",2355,0,"Nidogen-1",".",".",".",".","pfam07474","G2F","G2F domain. Nidogen, an invariant component of basement membranes, is a multifunctional protein that interacts with most other major basement membrane proteins. The G2 fragment or (G2F domain) contains binding sites for collagen IV and perlecan. The structure is composed of an 11-stranded beta-barrel with a central helix. This domain is structurally related to that of green fluorescent protein pfam01353. A large surface patch on the beta-barrel is conserved in all metazoan nidogens.","GO:0007160|cell-matrix adhesion;GO:0010811|positive regulation of cell-substrate adhesion;GO:0030198|extracellular matrix organization;GO:0032836|glomerular basement membrane development;","GO:0005576|extracellular region;GO:0005604|basement membrane;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0031012|extracellular matrix;GO:0071944|cell periphery;","GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0005518|collagen binding;GO:0043236|laminin binding;GO:0043237|laminin-1 binding;GO:0043394|proteoglycan binding;GO:0050840|extracellular matrix binding;","K06826","NID; nidogen (entactin)"]
["ENSRNOG00000053400",10,0.643304382,904,58.36392113,0.011022295,-6.503431487,{"v":4.3329e-212,"d":"4.33E-212"},{"v":5.5862e-211,"d":"5.59E-211"},"down","yes","Cfi","protein_coding","chr2:218387990-218430561:+","gi|13162353|ref|NP_077071.1|",3089,0,"complement factor I precursor [Rattus norvegicus]","gi|59809146|gb|BC089798.1|",2011,0,"Rattus norvegicus complement factor I, mRNA (cDNA clone MGC:108679 IMAGE:7321559), complete cds","Q9WUW3",1194,0,"Complement factor I","mlr3307",103,{"v":7e-23,"d":"7.00E-23"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;GO:0006897|endocytosis;GO:0006956|complement activation;GO:0006958|complement activation, classical pathway;GO:0045087|innate immune response;GO:0071354|cellular response to interleukin-6;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0016020|membrane;","GO:0003674|molecular_function;GO:0004252|serine-type endopeptidase activity;GO:0005044|scavenger receptor activity;GO:0046872|metal ion binding;","K01333","CFI; complement factor I [EC:3.4.21.45]"]
["ENSRNOG00000002052",1914,123.1284587,4326,279.2946049,0.440855128,-1.181623455,{"v":6.18e-212,"d":"6.18E-212"},{"v":7.9495e-211,"d":"7.95E-211"},"down","yes","Ccdc80","protein_coding","chr11:55685872-55719137:-","gi|114431230|ref|NP_071988.2|",3839,0,"coiled-coil domain-containing protein 80 precursor [Rattus norvegicus]","gi|114431229|ref|NM_022543.2|",3125,0,"Rattus norvegicus coiled-coil domain containing 80 (Ccdc80), mRNA","Q6QD51",1483,0,"Coiled-coil domain-containing protein 80",".",".",".",".","pfam13778","DUF4174","Domain of unknown function (DUF4174). This domain of unknown function is found in a putative tumor suppressor gene and in a ligand for the the urokinase-type plasminogen activator receptor, which plays a role in cellular migration and adhesion.","GO:0009617|response to bacterium;GO:0010811|positive regulation of cell-substrate adhesion;GO:0030198|extracellular matrix organization;","GO:0005576|extracellular region;GO:0005604|basement membrane;GO:0005614|interstitial matrix;GO:0031012|extracellular matrix;","GO:0001968|fibronectin binding;GO:0005539|glycosaminoglycan binding;GO:0008201|heparin binding;",".","."]
["ENSRNOG00000014371",140,9.006261346,1213,78.31353576,0.115002614,-3.120261438,{"v":1.2944E-211,"d":"1.29E-211"},{"v":1.6576e-210,"d":"1.66E-210"},"down","yes","Cdh13","protein_coding","chr19:46349430-47387459:+","gi|20302073|ref|NP_620244.1|",3602,0,"cadherin-13 precursor [Rattus norvegicus]","gi|55742750|ref|NM_138889.2|",3378,0,"Rattus norvegicus cadherin 13 (Cdh13), mRNA","Q9WTR5",1368,0,"Cadherin-13",".",".",".",".","pfam08758","Cadherin_pro","Cadherin prodomain like. Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.","GO:0000278|mitotic cell cycle;GO:0001938|positive regulation of endothelial cell proliferation;GO:0001954|positive regulation of cell-matrix adhesion;GO:0002040|sprouting angiogenesis;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007162|negative regulation of cell adhesion;GO:0007266|Rho protein signal transduction;GO:0008285|negative regulation of cell proliferation;GO:0010033|response to organic substance;GO:0016339|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0016601|Rac protein signal transduction;GO:0030032|lamellipodium assembly;GO:0030100|regulation of endocytosis;GO:0030335|positive regulation of cell migration;GO:0042058|regulation of epidermal growth factor receptor signaling pathway;GO:0043542|endothelial cell migration;GO:0043616|keratinocyte proliferation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0050850|positive regulation of calcium-mediated signaling;GO:0050927|positive regulation of positive chemotaxis;GO:0051668|localization within membrane;GO:0055096|low-density lipoprotein particle mediated signaling;GO:0098609|cell-cell adhesion;GO:0098742|cell-cell adhesion via plasma-membrane adhesion molecules;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005901|caveola;GO:0009897|external side of plasma membrane;GO:0016342|catenin complex;GO:0031225|anchored component of membrane;GO:0043005|neuron projection;GO:0045202|synapse;GO:0048471|perinuclear region of cytoplasm;GO:0098982|GABA-ergic synapse;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;GO:0030169|low-density lipoprotein particle binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0045296|cadherin binding;GO:0055100|adiponectin binding;GO:0071813|lipoprotein particle binding;","K06808","CDH13; cadherin 13, H-cadherin"]
["ENSRNOG00000056585",584,37.5689759,2157,139.2599313,0.269775919,-1.890166522,{"v":1.6616e-211,"d":"1.66E-211"},{"v":2.123e-210,"d":"2.12E-210"},"down","yes","Fscn1","protein_coding","chr12:11597048-11610211:-","gi|149034971|gb|EDL89691.1|",2562,0,"rCG42612, isoform CRA_b [Rattus norvegicus]","gi|201066379|ref|NM_001100806.1|",1588,0,"Rattus norvegicus fascin actin-bundling protein 1 (Fscn1), mRNA","P85845",984,0,"Fascin",".",".",".",".","pfam06268","Fascin","Fascin domain. This family consists of several eukaryotic fascin or singed proteins. The fascins are a structurally unique and evolutionarily conserved group of actin cross-linking proteins. Fascins function in the organisation of two major forms of actin-based structures: dynamic, cortical cell protrusions and cytoplasmic microfilament bundles. The cortical structures, which include filopodia, spikes, lamellipodial ribs, oocyte microvilli and the dendrites of dendritic cells, have roles in cell-matrix adhesion, cell interactions and cell migration, whereas the cytoplasmic actin bundles appear to participate in cell architecture.  Dictyostelium hisactophilin, another actin-binding protein, is a submembranous pH sensor that signals slight changes of the H+ concentration to actin by inducing actin polymerization and binding to microfilaments only at pH values below seven. Members of this family are histidine rich, typically contain the repeated motif of HHXH.",".",".",".",".","."]
["ENSRNOG00000007300",310,19.94243584,1608,103.8154703,0.19209503,-2.380107905,{"v":5.7918e-211,"d":"5.79E-211"},{"v":7.3672e-210,"d":"7.37E-210"},"down","yes","C1qtnf6","protein_coding","chr7:110077878-110084412:-","gi|77917558|ref|NP_001030104.1|",1324,{"v":2E-175,"d":"2.00E-175"},"complement C1q tumor necrosis factor-related protein 6 precursor [Rattus norvegicus]","gi|77917557|ref|NM_001034932.1|",1953,0,"Rattus norvegicus C1q and tumor necrosis factor related protein 6 (C1qtnf6), mRNA","Q3T1I2",514,{"v":6e-177,"d":"6.00E-177"},"Complement C1q tumor necrosis factor-related protein 6",".",".",".",".","pfam00386","C1q","C1q domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.",".","GO:0005581|collagen trimer;GO:0005615|extracellular space;GO:0032991|protein-containing complex;","GO:0042802|identical protein binding;","K19470","C1QTNF1_6_8; complement C1q tumor necrosis factor-related protein 1/6/8"]
["ENSRNOG00000019211",895,57.57574218,2703,174.5107066,0.329926704,-1.599782544,{"v":5.4972e-210,"d":"5.50E-210"},{"v":6.9461e-209,"d":"6.95E-209"},"down","yes","Olfml3","protein_coding","chr2:191244221-191247050:-","gi|157821459|ref|NP_001101178.1|",1818,0,"olfactomedin-like protein 3 precursor [Rattus norvegicus]","gi|157821458|ref|NM_001107708.1|",1758,0,"Rattus norvegicus olfactomedin-like 3 (Olfml3), mRNA","B0BNI5",687,0,"Olfactomedin-like protein 3",".",".",".",".","pfam02191","OLF","Olfactomedin-like domain.",".","GO:0005576|extracellular region;",".","K25448","OLFML1_3; olfactomedin-like protein 1/3"]
["ENSRNOG00000005277",377,24.2525752,1743,112.5313214,0.215518443,-2.21411676,{"v":1.2651E-209,"d":"1.27E-209"},{"v":1.595E-208,"d":"1.60E-208"},"down","yes","Ptprv","protein_coding","chr13:46548128-46568329:-","gi|14861868|ref|NP_149090.1|",8588,0,"receptor-type tyrosine-protein phosphatase V precursor [Rattus norvegicus]","gi|14861867|ref|NM_033099.1|",5422,0,"Rattus norvegicus protein tyrosine phosphatase, receptor type, V (Ptprv), mRNA","Q64612",3313,0,"Receptor-type tyrosine-protein phosphatase V","SPAC26F1.10c",135,{"v":5e-32,"d":"5.00E-32"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0006470|protein dephosphorylation;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0046849|bone remodeling;","GO:0016021|integral component of membrane;","GO:0004725|protein tyrosine phosphatase activity;","K18036","PTPRV, ESP; receptor-type tyrosine-protein phosphatase V [EC:3.1.3.48]"]
["ENSRNOG00000003217",2192,141.0123205,4703,303.634426,0.464414798,-1.106514153,{"v":2.0116E-207,"d":"2.01E-207"},{"v":2.514e-206,"d":"2.51E-206"},"down","yes","Lgals3bp","protein_coding","chr10:103619908-103629256:-","gi|149054938|gb|EDM06755.1|",2999,0,"lectin, galactoside-binding, soluble, 3 binding protein, isoform CRA_a [Rattus norvegicus]","gi|20806134|ref|NM_139096.1|",2090,0,"Rattus norvegicus lectin, galactoside-binding, soluble, 3 binding protein (Lgals3bp), mRNA","O70513",1158,0,"Galectin-3-binding protein",".",".",".",".","pfam00530","SRCR","Scavenger receptor cysteine-rich domain. These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.","GO:0006897|endocytosis;GO:0007155|cell adhesion;","GO:0005615|extracellular space;GO:0016020|membrane;","GO:0005044|scavenger receptor activity;","K17300","LGALS3BP; galectin-3-binding protein"]
["ENSRNOG00000018524",1185,76.23156925,3169,204.5965332,0.372594628,-1.42432122,{"v":2.0585e-207,"d":"2.06E-207"},{"v":2.5669E-206,"d":"2.57E-206"},"down","yes","Ezr","protein_coding","chr1:46967658-47011505:-","gi|52138521|ref|NP_062230.1|",2603,0,"ezrin [Rattus norvegicus]","gi|52138520|ref|NM_019357.1|",2372,0,"Rattus norvegicus ezrin (Ezr), mRNA","P31977",1007,0,"Ezrin",".",".",".",".","pfam00769","ERM","Ezrin/radixin/moesin family. This family of proteins contain a band 4.1 domain (pfam00373), at their amino terminus. This family represents the rest of these proteins.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001951|intestinal D-glucose absorption;GO:0003376|sphingosine-1-phosphate receptor signaling pathway;GO:0007159|leukocyte cell-cell adhesion;GO:0008360|regulation of cell shape;GO:0010628|positive regulation of gene expression;GO:0010737|protein kinase A signaling;GO:0022614|membrane to membrane docking;GO:0030033|microvillus assembly;GO:0030855|epithelial cell differentiation;GO:0030953|astral microtubule organization;GO:0031532|actin cytoskeleton reorganization;GO:0031623|receptor internalization;GO:0032532|regulation of microvillus length;GO:0032703|negative regulation of interleukin-2 production;GO:0034629|cellular protein-containing complex localization;GO:0035088|establishment or maintenance of apical/basal cell polarity;GO:0040018|positive regulation of multicellular organism growth;GO:0043622|cortical microtubule organization;GO:0046847|filopodium assembly;GO:0048015|phosphatidylinositol-mediated signaling;GO:0050714|positive regulation of protein secretion;GO:0050860|negative regulation of T cell receptor signaling pathway;GO:0051017|actin filament bundle assembly;GO:0051660|establishment of centrosome localization;GO:0061028|establishment of endothelial barrier;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0071320|cellular response to cAMP;GO:0072659|protein localization to plasma membrane;GO:0072697|protein localization to cell cortex;GO:1902115|regulation of organelle assembly;GO:1902896|terminal web assembly;GO:1902966|positive regulation of protein localization to early endosome;GO:1903078|positive regulation of protein localization to plasma membrane;GO:1903364|positive regulation of cellular protein catabolic process;GO:1903753|negative regulation of p38MAPK cascade;GO:2000643|positive regulation of early endosome to late endosome transport;","GO:0001650|fibrillar center;GO:0001726|ruffle;GO:0001772|immunological synapse;GO:0001931|uropod;GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0005902|microvillus;GO:0005903|brush border;GO:0005925|focal adhesion;GO:0005938|cell cortex;GO:0015629|actin cytoskeleton;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0019898|extrinsic component of membrane;GO:0030175|filopodium;GO:0030315|T-tubule;GO:0031528|microvillus membrane;GO:0032587|ruffle membrane;GO:0032991|protein-containing complex;GO:0036064|ciliary basal body;GO:0042995|cell projection;GO:0044297|cell body;GO:0044393|microspike;GO:0044853|plasma membrane raft;GO:0045121|membrane raft;GO:0045177|apical part of cell;GO:0048471|perinuclear region of cytoplasm;GO:0051286|cell tip;GO:0071944|cell periphery;GO:0097449|astrocyte projection;GO:0097454|Schwann cell microvillus;GO:0098592|cytoplasmic side of apical plasma membrane;","GO:0003779|actin binding;GO:0005198|structural molecule activity;GO:0005515|protein binding;GO:0008017|microtubule binding;GO:0008022|protein C-terminus binding;GO:0019904|protein domain specific binding;GO:0034236|protein kinase A catalytic subunit binding;GO:0034237|protein kinase A regulatory subunit binding;GO:0042802|identical protein binding;GO:0044548|S100 protein binding;GO:0044877|protein-containing complex binding;GO:0050839|cell adhesion molecule binding;GO:0051015|actin filament binding;GO:0051018|protein kinase A binding;GO:0051117|ATPase binding;GO:0097718|disordered domain specific binding;","K08007","VIL2; villin 2 (ezrin)"]
["ENSRNOG00000026647",574,36.92567152,2113,136.4192095,0.270677947,-1.885350745,{"v":1.5686e-206,"d":"1.57E-206"},{"v":1.9518e-205,"d":"1.95E-205"},"down","yes","Cxcl16","protein_coding","chr10:55166723-55171592:-","gi|62945312|ref|NP_001017478.1|",1018,{"v":2e-130,"d":"2.00E-130"},"C-X-C motif chemokine 16 precursor [Rattus norvegicus]","gi|65993504|gb|DQ025528.1|",1255,0,"Rattus norvegicus CXCL16 (Cxcl16) mRNA, complete cds","Q6AXU5",396,{"v":5e-132,"d":"5.00E-132"},"C-X-C motif chemokine 16",".",".",".",".","pfam15455","Pro-rich_19","Proline-rich 19. This family includes proline-rich protein 19.","GO:0006898|receptor-mediated endocytosis;GO:0007165|signal transduction;GO:0010818|T cell chemotaxis;GO:0030307|positive regulation of cell growth;GO:0030335|positive regulation of cell migration;GO:0034097|response to cytokine;GO:0034341|response to interferon-gamma;GO:0034612|response to tumor necrosis factor;GO:0071222|cellular response to lipopolysaccharide;","GO:0005615|extracellular space;GO:0016021|integral component of membrane;","GO:0005041|low-density lipoprotein particle receptor activity;GO:0005044|scavenger receptor activity;GO:0008009|chemokine activity;GO:0042379|chemokine receptor binding;","K10035","CXCL16; C-X-C motif chemokine 16"]
["ENSRNOG00000033110",324,20.84306197,1615,104.2674033,0.199900077,-2.322649066,{"v":6.9434E-206,"d":"6.94E-206"},{"v":8.6208e-205,"d":"8.62E-205"},"down","yes","Svep1","protein_coding","chr5:72811410-72988525:-","gi|564305384|ref|XP_006225372.1|",18699,0,"PREDICTED: sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 isoform X1 [Rattus norvegicus]","gi|672019379|ref|XM_006225310.2|",11211,0,"PREDICTED: Rattus norvegicus sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (Svep1), transcript variant X1, mRNA","P0C6B8",7073,0,"Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0001945|lymph vessel development;GO:0003017|lymph circulation;GO:0007155|cell adhesion;GO:0008544|epidermis development;GO:0010467|gene expression;GO:0036303|lymph vessel morphogenesis;GO:0048014|Tie signaling pathway;GO:0120193|tight junction organization;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0016020|membrane;","GO:0003682|chromatin binding;GO:0005509|calcium ion binding;","K24469","SVEP1; sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1"]
["ENSRNOG00000019451",1405,90.38426565,3501,226.0310707,0.399875404,-1.322377551,{"v":1.1916E-204,"d":"1.19E-204"},{"v":1.4731E-203,"d":"1.47E-203"},"down","yes","Smtn","protein_coding","chr14:78397778-78420886:-","gi|564384245|ref|XP_006251256.1|",3769,0,"PREDICTED: smoothelin isoform X1 [Rattus norvegicus]","gi|672076587|ref|XM_006251194.2|",3143,0,"PREDICTED: Rattus norvegicus smoothelin (Smtn), transcript variant X1, mRNA","Q921U8",1305,0,"Smoothelin","SPAC15A10.08",92,{"v":4e-18,"d":"4.00E-18"},"COG5069","pfam00307","CH","Calponin homology (CH) domain. The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.","GO:0003085|negative regulation of systemic arterial blood pressure;GO:0030036|actin cytoskeleton organization;GO:0060452|positive regulation of cardiac muscle contraction;","GO:0005815|microtubule organizing center;GO:0031941|filamentous actin;",".",".","."]
["ENSRNOG00000007081",2482,159.6681476,5099,329.2009224,0.485017315,-1.043891842,{"v":1.4048E-204,"d":"1.40E-204"},{"v":1.7329e-203,"d":"1.73E-203"},"down","yes","Xdh","protein_coding","chr6:21530113-21592268:+","gi|149050678|gb|EDM02851.1|",6739,0,"rCG61833 [Rattus norvegicus]","gi|8394543|ref|NM_017154.1|",4142,0,"Rattus norvegicus xanthine dehydrogenase (Xdh), mRNA","P22985",2601,0,"Xanthine dehydrogenase/oxidase","CC2618",589,0,"COG4631","pfam02738","Ald_Xan_dh_C2","Molybdopterin-binding domain of aldehyde dehydrogenase.","GO:0000255|allantoin metabolic process;GO:0001933|negative regulation of protein phosphorylation;GO:0001937|negative regulation of endothelial cell proliferation;GO:0006147|guanine catabolic process;GO:0006148|inosine catabolic process;GO:0006149|deoxyinosine catabolic process;GO:0006154|adenosine catabolic process;GO:0006157|deoxyadenosine catabolic process;GO:0006161|deoxyguanosine catabolic process;GO:0006196|AMP catabolic process;GO:0006204|IMP catabolic process;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007568|aging;GO:0007595|lactation;GO:0009114|hypoxanthine catabolic process;GO:0009115|xanthine catabolic process;GO:0009408|response to heat;GO:0010044|response to aluminum ion;GO:0010629|negative regulation of gene expression;GO:0016226|iron-sulfur cluster assembly;GO:0030856|regulation of epithelial cell differentiation;GO:0032496|response to lipopolysaccharide;GO:0034465|response to carbon monoxide;GO:0042542|response to hydrogen peroxide;GO:0045602|negative regulation of endothelial cell differentiation;GO:0046038|GMP catabolic process;GO:0046055|dGMP catabolic process;GO:0046059|dAMP catabolic process;GO:0051898|negative regulation of protein kinase B signaling;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0097184|response to azide;GO:1900745|positive regulation of p38MAPK cascade;GO:1900747|negative regulation of vascular endothelial growth factor signaling pathway;GO:2000379|positive regulation of reactive oxygen species metabolic process;GO:2001213|negative regulation of vasculogenesis;","GO:0005615|extracellular space;GO:0005777|peroxisome;GO:0005829|cytosol;GO:0016529|sarcoplasmic reticulum;","GO:0004854|xanthine dehydrogenase activity;GO:0004855|xanthine oxidase activity;GO:0005506|iron ion binding;GO:0016491|oxidoreductase activity;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0043546|molybdopterin cofactor binding;GO:0050421|nitrite reductase (NO-forming) activity;GO:0050660|flavin adenine dinucleotide binding;GO:0051537|2 iron, 2 sulfur cluster binding;GO:0070674|hypoxanthine dehydrogenase activity;GO:0070675|hypoxanthine oxidase activity;GO:0071949|FAD binding;","K00106","XDH; xanthine dehydrogenase/oxidase [EC:1.17.1.4 1.17.3.2]"]
["ENSRNOG00000016581",107,6.883356886,1097,70.82436004,0.097189115,-3.363061443,{"v":1.8964e-204,"d":"1.90E-204"},{"v":2.3342e-203,"d":"2.33E-203"},"down","yes","Serpinb1a","protein_coding","chr17:31590677-31599102:+","gi|72255515|ref|NP_001026812.1|",1933,0,"leukocyte elastase inhibitor A [Rattus norvegicus]","gi|72255514|ref|NM_001031642.1|",1266,0,"Rattus norvegicus serine (or cysteine) proteinase inhibitor, clade B, member 1a (Serpinb1a), mRNA","Q4G075",746,0,"Leukocyte elastase inhibitor A","MA3388",197,{"v":9e-57,"d":"9.00E-57"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0006954|inflammatory response;GO:0010951|negative regulation of endopeptidase activity;GO:0019725|cellular homeostasis;GO:0032691|negative regulation of interleukin-1 beta production;GO:0042176|regulation of protein catabolic process;GO:0044342|type B pancreatic cell proliferation;GO:0045088|regulation of innate immune response;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005764|lysosome;GO:0005769|early endosome;GO:0036464|cytoplasmic ribonucleoprotein granule;","GO:0004867|serine-type endopeptidase inhibitor activity;GO:0030414|peptidase inhibitor activity;","K23425","SERPINB1; leukocyte elastase inhibitor"]
["ENSRNOG00000028566",355,22.83730556,1663,107.3663726,0.212704453,-2.233077858,{"v":3.4773e-202,"d":"3.48E-202"},{"v":4.2436e-201,"d":"4.24E-201"},"down","yes","Pld4","protein_coding","chr6:131818860-131826376:+","gi|187281923|ref|NP_001119760.1|",2755,0,"phospholipase D4 [Rattus norvegicus]","gi|187281922|ref|NM_001126288.1|",1989,0,"Rattus norvegicus phospholipase D family, member 4 (Pld4), mRNA","Q8BG07",876,0,"Phospholipase D4",".",".",".",".","pfam13918","PLDc_3","PLD-like domain.","GO:0002244|hematopoietic progenitor cell differentiation;GO:0006259|DNA metabolic process;GO:0006909|phagocytosis;GO:0090305|nucleic acid phosphodiester bond hydrolysis;GO:1900015|regulation of cytokine production involved in inflammatory response;","GO:0005634|nucleus;GO:0005769|early endosome;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0032588|trans-Golgi network membrane;GO:0045335|phagocytic vesicle;","GO:0045145|single-stranded DNA 5'-3' exodeoxyribonuclease activity;","K16860","PLD3_4; phospholipase D3/4 [EC:3.1.4.4]"]
["ENSRNOG00000010165",146,9.392243975,1189,76.76405113,0.122352115,-3.03088906,{"v":5.7263E-202,"d":"5.73E-202"},{"v":6.9733E-201,"d":"6.97E-201"},"down","yes","Tnfaip2","protein_coding","chr6:130476889-130489914:+","gi|212549631|ref|NP_001131105.1|",3147,0,"tumor necrosis factor alpha-induced protein 2 [Rattus norvegicus]","gi|212549630|ref|NM_001137633.1|",2312,0,"Rattus norvegicus TNF alpha induced protein 2 (Tnfaip2), mRNA","Q61333",1082,0,"Tumor necrosis factor alpha-induced protein 2",".",".",".",".","pfam06046","Sec6","Exocyst complex component Sec6. Sec6 is a component of the multiprotein exocyst complex. Sec6 interacts with Sec8, Sec10 and Exo70.These exocyst proteins localize to regions of active exocytosis-at the growing ends of interphase cells and in the medial region of cells undergoing cytokinesis-in an F-actin-dependent and exocytosis- independent manner.","GO:0006887|exocytosis;GO:0051601|exocyst localization;","GO:0000145|exocyst;","GO:0000149|SNARE binding;","K19989","TNFAIP2, EXOC3L3; tumor necrosis factor alpha-induced protein 2"]
["ENSRNOG00000003486",168,10.80751362,1243,80.25039155,0.13467241,-2.892473778,{"v":9.4928e-202,"d":"9.49E-202"},{"v":1.1516E-200,"d":"1.15E-200"},"down","yes","Mnda","protein_coding","chr13:86017892-86034201:-","gi|58865634|ref|NP_001012029.1|",1794,0,"myeloid cell nuclear differentiation antigen [Rattus norvegicus]","gi|58865633|ref|NM_001012029.1|",1302,0,"Rattus norvegicus myeloid cell nuclear differentiation antigen (Mnda), mRNA","P0DOV2",427,{"v":5e-140,"d":"5.00E-140"},"Interferon-activable protein 204",".",".",".",".","pfam02760","HIN","HIN-200/IF120x domain. This domain has no know function. It is found in one or two copies per protein, and is found associated with the PAAD/DAPIN domain pfam02758.","GO:0002218|activation of innate immune response;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006974|cellular response to DNA damage stimulus;GO:0009617|response to bacterium;GO:0030889|negative regulation of B cell proliferation;GO:0032731|positive regulation of interleukin-1 beta production;GO:0035457|cellular response to interferon-alpha;GO:0035458|cellular response to interferon-beta;GO:0043065|positive regulation of apoptotic process;GO:0045669|positive regulation of osteoblast differentiation;GO:0048839|inner ear development;GO:0050853|B cell receptor signaling pathway;","GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005829|cytosol;GO:0042405|nuclear inclusion body;GO:0043231|intracellular membrane-bounded organelle;","GO:0003690|double-stranded DNA binding;GO:0003712|transcription coregulator activity;",".","."]
["ENSRNOG00000020871",1363,87.68238725,3413,220.349627,0.39792392,-1.329435472,{"v":3.4872e-201,"d":"3.49E-201"},{"v":4.2196E-200,"d":"4.22E-200"},"down","yes","Ltbp4","protein_coding","chr1:82600136-82632178:-","gi|281371412|ref|NP_001163807.1|",7240,0,"latent-transforming growth factor beta-binding protein 4 precursor [Rattus norvegicus]","gi|281371411|ref|NM_001170336.1|",5157,0,"Rattus norvegicus latent transforming growth factor beta binding protein 4 (Ltbp4), mRNA","Q8N2S1",2437,0,"Latent-transforming growth factor beta-binding protein 4",".",".",".",".","pfam00683","TB","TB domain. This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.","GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0030162|regulation of proteolysis;GO:0046879|hormone secretion;GO:0048251|elastic fiber assembly;","GO:0001527|microfibril;GO:0031012|extracellular matrix;GO:0062023|collagen-containing extracellular matrix;","GO:0005509|calcium ion binding;GO:0050431|transforming growth factor beta binding;","K08023","LTBP2_3_4; latent transforming growth factor beta binding protein 2/3/4"]
["ENSRNOG00000019850",204,13.12340939,1327,85.67358776,0.153179174,-2.706707933,{"v":3.7272e-201,"d":"3.73E-201"},{"v":4.5005e-200,"d":"4.50E-200"},"down","yes","Speg","protein_coding","chr9:76865754-76923144:+","gi|157818307|ref|NP_001102272.1|",14450,0,"striated muscle-specific serine/threonine-protein kinase isoform 1 [Rattus norvegicus]","gi|157818306|ref|NM_001108802.1|",10837,0,"Rattus norvegicus SPEG complex locus (Speg), transcript variant 1, mRNA","Q63638",5570,0,"Striated muscle-specific serine/threonine-protein kinase",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0001701|in utero embryonic development;GO:0006468|protein phosphorylation;GO:0042692|muscle cell differentiation;GO:0055013|cardiac muscle cell development;GO:0060541|respiratory system development;GO:0072359|circulatory system development;","GO:0005634|nucleus;","GO:0004672|protein kinase activity;GO:0005524|ATP binding;","K08809","SPEG; striated muscle-specific serine/threonine protein kinase [EC:2.7.11.1]"]
["ENSRNOG00000012749",1621,104.2796403,3809,245.9161234,0.42404556,-1.237708816,{"v":6.6185e-201,"d":"6.62E-201"},{"v":7.9747e-200,"d":"7.97E-200"},"down","yes","C1qb","protein_coding","chr5:149118846-149124407:-","gi|149024327|gb|EDL80824.1|",966,{"v":3e-127,"d":"3.00E-127"},"complement component 1, q subcomponent, beta polypeptide, isoform CRA_b [Rattus norvegicus]","gi|9506432|ref|NM_019262.1|",1048,0,"Rattus norvegicus complement component 1, q subcomponent, B chain (C1qb), mRNA","P31721",370,{"v":4e-126,"d":"4.00E-126"},"Complement C1q subcomponent subunit B",".",".",".",".","pfam00386","C1q","C1q domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.","GO:0006955|immune response;GO:0006958|complement activation, classical pathway;GO:0007420|brain development;GO:0007568|aging;GO:0010033|response to organic substance;GO:0045087|innate immune response;GO:0048839|inner ear development;GO:0051384|response to glucocorticoid;GO:0098883|synapse pruning;","GO:0005576|extracellular region;GO:0005581|collagen trimer;GO:0005602|complement component C1 complex;GO:0045202|synapse;GO:0098794|postsynapse;","GO:0003674|molecular_function;GO:0042802|identical protein binding;","K03987","C1QB; complement C1q subcomponent subunit B"]
["ENSRNOG00000016758",814,52.36497668,2512,162.1793915,0.322883051,-1.630916384,{"v":9.8574e-201,"d":"9.86E-201"},{"v":1.1852e-199,"d":"1.19E-199"},"down","yes","Loxl2","protein_coding","chr15:44683880-44773067:+","gi|201066363|ref|NP_001099517.2|",3926,0,"lysyl oxidase homolog 2 precursor [Rattus norvegicus]","gi|201066362|ref|NM_001106047.2|",2566,0,"Rattus norvegicus lysyl oxidase-like 2 (Loxl2), mRNA","B5DF27",1514,0,"Lysyl oxidase homolog 2",".",".",".",".","pfam01186","Lysyl_oxidase","Lysyl oxidase.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001666|response to hypoxia;GO:0001837|epithelial to mesenchymal transition;GO:0001935|endothelial cell proliferation;GO:0002040|sprouting angiogenesis;GO:0006464|cellular protein modification process;GO:0006897|endocytosis;GO:0010718|positive regulation of epithelial to mesenchymal transition;GO:0018057|peptidyl-lysine oxidation;GO:0030199|collagen fibril organization;GO:0032332|positive regulation of chondrocyte differentiation;GO:0043542|endothelial cell migration;GO:0045892|negative regulation of transcription, DNA-templated;GO:0046688|response to copper ion;GO:0070828|heterochromatin organization;GO:1902455|negative regulation of stem cell population maintenance;","GO:0000785|chromatin;GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005783|endoplasmic reticulum;GO:0016020|membrane;","GO:0004720|protein-lysine 6-oxidase activity;GO:0005044|scavenger receptor activity;GO:0005507|copper ion binding;GO:0005509|calcium ion binding;GO:0070492|oligosaccharide binding;","K00280","LOXL2_3_4; lysyl oxidase-like protein 2/3/4 [EC:1.4.3.-]"]
["ENSRNOG00000056836",1184,76.16723881,3123,201.6266877,0.377763676,-1.404444108,{"v":3.4855e-200,"d":"3.49E-200"},{"v":4.1646e-199,"d":"4.16E-199"},"down","yes","Cav1","protein_coding","chr4:45634918-45673705:+","gi|189083698|ref|NP_113744.2|",894,{"v":1e-110,"d":"1.00E-110"},"caveolin-1 isoform alpha [Rattus norvegicus]","gi|564345909|ref|XM_006236131.1|",1314,0,"PREDICTED: Rattus norvegicus caveolin 1, caveolae protein (Cav1), transcript variant X2, mRNA","P41350",347,{"v":2e-111,"d":"2.00E-111"},"Caveolin-1",".",".",".",".","pfam01146","Caveolin","Caveolin. All three known Caveolin forms have the FEDVIAEP caveolin 'signature motif' within their hydrophilic N-terminal domain. Caveolin 2 (Cav-2) is co-localized and co-expressed with Cav-1/VIP21, forms heterodimers with it and needs Cav-1 for proper membrane localisation. Cav-3 has greater protein sequence similarity to Cav-1 than to Cav-2. Cellular processes caveolins are involved in include vesicular transport, cholesterol homeostasis, signal transduction, and tumor suppression.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001525|angiogenesis;GO:0001570|vasculogenesis;GO:0001666|response to hypoxia;GO:0001937|negative regulation of endothelial cell proliferation;GO:0001938|positive regulation of endothelial cell proliferation;GO:0001960|negative regulation of cytokine-mediated signaling pathway;GO:0002026|regulation of the force of heart contraction;GO:0002931|response to ischemia;GO:0003057|regulation of the force of heart contraction by chemical signal;GO:0006641|triglyceride metabolic process;GO:0006816|calcium ion transport;GO:0006874|cellular calcium ion homeostasis;GO:0006940|regulation of smooth muscle contraction;GO:0007519|skeletal muscle tissue development;GO:0007584|response to nutrient;GO:0007595|lactation;GO:0008104|protein localization;GO:0008285|negative regulation of cell proliferation;GO:0009267|cellular response to starvation;GO:0009410|response to xenobiotic stimulus;GO:0009612|response to mechanical stimulus;GO:0009617|response to bacterium;GO:0009967|positive regulation of signal transduction;GO:0009968|negative regulation of signal transduction;GO:0010332|response to gamma radiation;GO:0010524|positive regulation of calcium ion transport into cytosol;GO:0010608|posttranscriptional regulation of gene expression;GO:0010628|positive regulation of gene expression;GO:0010656|negative regulation of muscle cell apoptotic process;GO:0010875|positive regulation of cholesterol efflux;GO:0010952|positive regulation of peptidase activity;GO:0015031|protein transport;GO:0016050|vesicle organization;GO:0019065|receptor-mediated endocytosis of virus by host cell;GO:0019217|regulation of fatty acid metabolic process;GO:0019915|lipid storage;GO:0030154|cell differentiation;GO:0030193|regulation of blood coagulation;GO:0030335|positive regulation of cell migration;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030514|negative regulation of BMP signaling pathway;GO:0030857|negative regulation of epithelial cell differentiation;GO:0030879|mammary gland development;GO:0031100|animal organ regeneration;GO:0031116|positive regulation of microtubule polymerization;GO:0031295|T cell costimulation;GO:0031397|negative regulation of protein ubiquitination;GO:0031398|positive regulation of protein ubiquitination;GO:0031623|receptor internalization;GO:0032091|negative regulation of protein binding;GO:0032092|positive regulation of protein binding;GO:0032507|maintenance of protein location in cell;GO:0032570|response to progesterone;GO:0033137|negative regulation of peptidyl-serine phosphorylation;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0033344|cholesterol efflux;GO:0033484|nitric oxide homeostasis;GO:0034141|positive regulation of toll-like receptor 3 signaling pathway;GO:0038016|insulin receptor internalization;GO:0042060|wound healing;GO:0042310|vasoconstriction;GO:0042532|negative regulation of tyrosine phosphorylation of STAT protein;GO:0042632|cholesterol homeostasis;GO:0043085|positive regulation of catalytic activity;GO:0043407|negative regulation of MAP kinase activity;GO:0043409|negative regulation of MAPK cascade;GO:0043627|response to estrogen;GO:0044860|protein localization to plasma membrane raft;GO:0045019|negative regulation of nitric oxide biosynthetic process;GO:0045665|negative regulation of neuron differentiation;GO:0045807|positive regulation of endocytosis;GO:0045907|positive regulation of vasoconstriction;GO:0046426|negative regulation of JAK-STAT cascade;GO:0046785|microtubule polymerization;GO:0048550|negative regulation of pinocytosis;GO:0048662|negative regulation of smooth muscle cell proliferation;GO:0051001|negative regulation of nitric-oxide synthase activity;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051384|response to glucocorticoid;GO:0051480|regulation of cytosolic calcium ion concentration;GO:0051592|response to calcium ion;GO:0051899|membrane depolarization;GO:0052547|regulation of peptidase activity;GO:0055074|calcium ion homeostasis;GO:0060056|mammary gland involution;GO:0060355|positive regulation of cell adhesion molecule production;GO:0060546|negative regulation of necroptotic process;GO:0061099|negative regulation of protein tyrosine kinase activity;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0070836|caveola assembly;GO:0071260|cellular response to mechanical stimulus;GO:0071360|cellular response to exogenous dsRNA;GO:0071375|cellular response to peptide hormone stimulus;GO:0071455|cellular response to hyperoxia;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0071711|basement membrane organization;GO:0072584|caveolin-mediated endocytosis;GO:0086091|regulation of heart rate by cardiac conduction;GO:0086098|angiotensin-activated signaling pathway involved in heart process;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:0090398|cellular senescence;GO:0097190|apoptotic signaling pathway;GO:0098903|regulation of membrane repolarization during action potential;GO:0098911|regulation of ventricular cardiac muscle cell action potential;GO:0120162|positive regulation of cold-induced thermogenesis;GO:1900027|regulation of ruffle assembly;GO:1900085|negative regulation of peptidyl-tyrosine autophosphorylation;GO:1901380|negative regulation of potassium ion transmembrane transport;GO:1901844|regulation of cell communication by electrical coupling involved in cardiac conduction;GO:1903071|positive regulation of ER-associated ubiquitin-dependent protein catabolic process;GO:1903361|protein localization to basolateral plasma membrane;GO:1903598|positive regulation of gap junction assembly;GO:1903609|negative regulation of inward rectifier potassium channel activity;GO:2000286|receptor internalization involved in canonical Wnt signaling pathway;GO:2000535|regulation of entry of bacterium into host cell;GO:2000811|negative regulation of anoikis;GO:2001238|positive regulation of extrinsic apoptotic signaling pathway;GO:2001244|positive regulation of intrinsic apoptotic signaling pathway;GO:2001258|negative regulation of cation channel activity;","GO:0000139|Golgi membrane;GO:0002080|acrosomal membrane;GO:0002095|caveolar macromolecular signaling complex;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005768|endosome;GO:0005778|peroxisomal membrane;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005811|lipid droplet;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005901|caveola;GO:0005925|focal adhesion;GO:0005929|cilium;GO:0005938|cell cortex;GO:0009925|basal plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0031410|cytoplasmic vesicle;GO:0032991|protein-containing complex;GO:0042383|sarcolemma;GO:0045121|membrane raft;GO:0048471|perinuclear region of cytoplasm;GO:0070382|exocytic vesicle;","GO:0000149|SNARE binding;GO:0005102|signaling receptor binding;GO:0005515|protein binding;GO:0016504|peptidase activator activity;GO:0019899|enzyme binding;GO:0019900|kinase binding;GO:0019901|protein kinase binding;GO:0019905|syntaxin binding;GO:0030674|protein binding, bridging;GO:0031267|small GTPase binding;GO:0033612|receptor serine/threonine kinase binding;GO:0042802|identical protein binding;GO:0044325|ion channel binding;GO:0044877|protein-containing complex binding;GO:0046982|protein heterodimerization activity;GO:0050998|nitric-oxide synthase binding;GO:0051117|ATPase binding;GO:0060090|molecular adaptor activity;GO:0070320|inward rectifier potassium channel inhibitor activity;","K06278","CAV1; caveolin 1"]
["ENSRNOG00000012094",72,4.631791549,977,63.07693688,0.073430826,-3.76747037,{"v":1.1056E-198,"d":"1.11E-198"},{"v":1.3073e-197,"d":"1.31E-197"},"down","yes","Ltbp2","protein_coding","chr6:104429947-104526208:-","gi|564356682|ref|XP_006240412.1|",9165,0,"PREDICTED: latent-transforming growth factor beta-binding protein 2 isoform X1 [Rattus norvegicus]","gi|672056761|ref|XM_006240350.2|",6579,0,"PREDICTED: Rattus norvegicus latent transforming growth factor beta binding protein 2 (Ltbp2), transcript variant X1, mRNA","O35806",3264,0,"Latent-transforming growth factor beta-binding protein 2",".",".",".",".","pfam00683","TB","TB domain. This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.","GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0097435|supramolecular fiber organization;","GO:0005576|extracellular region;","GO:0005509|calcium ion binding;GO:0008201|heparin binding;GO:0019838|growth factor binding;GO:0050436|microfibril binding;","K08023","LTBP2_3_4; latent transforming growth factor beta binding protein 2/3/4"]
["ENSRNOG00000004925",1609,103.507675,3775,243.7210202,0.424697365,-1.235492938,{"v":1.4118e-198,"d":"1.41E-198"},{"v":1.666e-197,"d":"1.67E-197"},"down","yes","Ppp1r12a","protein_coding","chr7:43482803-43593425:+","gi|564359162|ref|XP_006241370.1|",4106,0,"PREDICTED: protein phosphatase 1 regulatory subunit 12A isoform X1 [Rattus norvegicus]","gi|564359161|ref|XM_006241308.1|",5318,0,"PREDICTED: Rattus norvegicus protein phosphatase 1, regulatory subunit 12A (Ppp1r12a), transcript variant X1, mRNA","Q10728",1409,0,"Protein phosphatase 1 regulatory subunit 12A","all2748",91.7,{"v":3e-18,"d":"3.00E-18"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0000278|mitotic cell cycle;GO:0006470|protein dephosphorylation;GO:0007098|centrosome cycle;GO:0007165|signal transduction;GO:0030155|regulation of cell adhesion;GO:0035507|regulation of myosin-light-chain-phosphatase activity;GO:0035508|positive regulation of myosin-light-chain-phosphatase activity;GO:0043086|negative regulation of catalytic activity;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046822|regulation of nucleocytoplasmic transport;GO:0050790|regulation of catalytic activity;GO:0071466|cellular response to xenobiotic stimulus;","GO:0000776|kinetochore;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0015629|actin cytoskeleton;GO:0030018|Z disc;GO:0031672|A band;GO:0043292|contractile fiber;GO:0072357|PTW/PP1 phosphatase complex;","GO:0004721|phosphoprotein phosphatase activity;GO:0004857|enzyme inhibitor activity;GO:0005515|protein binding;GO:0019208|phosphatase regulator activity;GO:0019901|protein kinase binding;GO:0071889|14-3-3 protein binding;","K06270","PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A"]
["ENSRNOG00000053450",944,60.72793365,2716,175.3500108,0.346324094,-1.529805334,{"v":8.4239E-198,"d":"8.42E-198"},{"v":9.9199e-197,"d":"9.92E-197"},"down","yes","Myadm","protein_coding","chr1:65864173-65874035:-","gi|148699227|gb|EDL31174.1|",1429,0,"myeloid-associated differentiation marker, isoform CRA_b, partial [Mus musculus]","gi|77748458|gb|BC107558.1|",2840,0,"Rattus norvegicus myeloid-associated differentiation marker, mRNA (cDNA clone MGC:124542 IMAGE:7932126), complete cds","Q6VBQ5",545,0,"Myeloid-associated differentiation marker",".",".",".",".","pfam01284","MARVEL","Membrane-associating domain. MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.","GO:0001933|negative regulation of protein phosphorylation;GO:0010629|negative regulation of gene expression;GO:0030335|positive regulation of cell migration;GO:0030837|negative regulation of actin filament polymerization;GO:0031579|membrane raft organization;GO:0034115|negative regulation of heterotypic cell-cell adhesion;GO:0061028|establishment of endothelial barrier;GO:0072659|protein localization to plasma membrane;GO:0090038|negative regulation of protein kinase C signaling;GO:1900026|positive regulation of substrate adhesion-dependent cell spreading;","GO:0001726|ruffle;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0016021|integral component of membrane;GO:0030864|cortical actin cytoskeleton;GO:0045121|membrane raft;",".",".","."]
["ENSRNOG00000008170",74,4.760452426,979,63.2060606,0.075316392,-3.730892303,{"v":9.6191e-198,"d":"9.62E-198"},{"v":1.1304E-196,"d":"1.13E-196"},"down","yes","Jph2","protein_coding","chr3:151994778-152058904:-","gi|83816931|ref|NP_001033063.1|",2615,0,"junctophilin-2 [Rattus norvegicus]","gi|672048005|ref|XM_006235526.2|",4169,0,"PREDICTED: Rattus norvegicus junctophilin 2 (Jph2), transcript variant X1, mRNA","Q2PS20",1011,0,"Junctophilin-2",".",".",".",".","pfam02493","MORN","MORN repeat. The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22).  #=GF CC   A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesised to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0045892|negative regulation of transcription, DNA-templated;GO:0055024|regulation of cardiac muscle tissue development;GO:0055074|calcium ion homeostasis;GO:0060316|positive regulation of ryanodine-sensitive calcium-release channel activity;","GO:0005634|nucleus;GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016529|sarcoplasmic reticulum;GO:0030018|Z disc;GO:0030314|junctional membrane complex;GO:0033017|sarcoplasmic reticulum membrane;","GO:0001046|core promoter sequence-specific DNA binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001786|phosphatidylserine binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;GO:0010314|phosphatidylinositol-5-phosphate binding;GO:0032266|phosphatidylinositol-3-phosphate binding;GO:0070273|phosphatidylinositol-4-phosphate binding;GO:0070300|phosphatidic acid binding;GO:0080025|phosphatidylinositol-3,5-bisphosphate binding;","K19530","JPH; junctophilin"]
["ENSRNOG00000000599",1458,93.79377887,3538,228.4198595,0.410620071,-1.284123948,{"v":1.0726e-197,"d":"1.07E-197"},{"v":1.2579e-196,"d":"1.26E-196"},"down","yes","Lama4","protein_coding","chr20:42392268-42533347:+","gi|827342570|ref|NP_001296376.1|",9747,0,"laminin subunit alpha-4 precursor [Rattus norvegicus]","gi|827342569|ref|NM_001309447.1|",6051,0,"Rattus norvegicus laminin subunit alpha 4 (Lama4), mRNA","P97927",3604,0,"Laminin subunit alpha-4",".",".",".",".","pfam06008","Laminin_I","Laminin Domain I. coiled-coil structure. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.","GO:0001568|blood vessel development;GO:0007155|cell adhesion;GO:0030155|regulation of cell adhesion;GO:0030334|regulation of cell migration;GO:0045995|regulation of embryonic development;GO:0050873|brown fat cell differentiation;GO:0120163|negative regulation of cold-induced thermogenesis;","GO:0005604|basement membrane;GO:0016020|membrane;GO:0031594|neuromuscular junction;GO:0043083|synaptic cleft;","GO:0005102|signaling receptor binding;","K06241","LAMA4; laminin, alpha 4"]
["ENSRNOG00000016701",120,7.719652582,1103,71.2117312,0.108404226,-3.205507099,{"v":2.596e-197,"d":"2.60E-197"},{"v":3.032e-196,"d":"3.03E-196"},"down","yes","Gng8","protein_coding","chr1:77564515-77568371:+","gi|291413312|ref|XP_002722922.1|",365,{"v":1e-38,"d":"1.00E-38"},"PREDICTED: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [Oryctolagus cuniculus]","gi|672034928|ref|XM_006228384.2|",557,0,"PREDICTED: Rattus norvegicus guanine nucleotide binding protein (G protein), gamma 8 (Gng8), transcript variant X1, mRNA","P63077",144,{"v":5e-40,"d":"5.00E-40"},"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8",".",".",".",".","pfam00631","G-gamma","GGL domain. G-protein gamma like domains (GGL) are found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling (RGS) proteins. It is also found fused to an inactive Galpha in the Dictyostelium protein gbqA. G-gamma likely shares a common origin with the helical N-terminal unit of G-beta. All organisms that posses a G-beta possess a G-gamma.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0007399|nervous system development;GO:0035176|social behavior;GO:0043584|nose development;GO:0071444|cellular response to pheromone;","GO:0005834|heterotrimeric G-protein complex;","GO:0031681|G-protein beta-subunit binding;","K04544","GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8"]
["ENSRNOG00000006094",171,11.00050493,1223,78.95915436,0.13931893,-2.843536793,{"v":3.4167E-195,"d":"3.42E-195"},{"v":3.9582e-194,"d":"3.96E-194"},"down","yes","Cd44","protein_coding","chr3:89157058-89244620:-","gi|149022754|gb|EDL79648.1|",3838,0,"CD44 antigen, isoform CRA_a [Rattus norvegicus]","gi|672046391|ref|XM_008762059.1|",3940,0,"PREDICTED: Rattus norvegicus Cd44 molecule (Cd44), transcript variant X8, mRNA","P15379",1312,0,"CD44 antigen",".",".",".",".","pfam00193","Xlink","Extracellular link domain.","GO:0001558|regulation of cell growth;GO:0001658|branching involved in ureteric bud morphogenesis;GO:0001955|blood vessel maturation;GO:0002246|wound healing involved in inflammatory response;GO:0002906|negative regulation of mature B cell apoptotic process;GO:0006954|inflammatory response;GO:0007155|cell adhesion;GO:0010628|positive regulation of gene expression;GO:0014070|response to organic cyclic compound;GO:0016055|Wnt signaling pathway;GO:0016477|cell migration;GO:0019221|cytokine-mediated signaling pathway;GO:0030214|hyaluronan catabolic process;GO:0031175|neuron projection development;GO:0031667|response to nutrient levels;GO:0033031|positive regulation of neutrophil apoptotic process;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0033189|response to vitamin A;GO:0033674|positive regulation of kinase activity;GO:0034116|positive regulation of heterotypic cell-cell adhesion;GO:0034238|macrophage fusion;GO:0042110|T cell activation;GO:0043066|negative regulation of apoptotic process;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043518|negative regulation of DNA damage response, signal transduction by p53 class mediator;GO:0044319|wound healing, spreading of cells;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0045590|negative regulation of regulatory T cell differentiation;GO:0050728|negative regulation of inflammatory response;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0051216|cartilage development;GO:0060442|branching involved in prostate gland morphogenesis;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070487|monocyte aggregation;GO:1900625|positive regulation of monocyte aggregation;GO:1902166|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:2000392|regulation of lamellipodium morphogenesis;GO:2000562|negative regulation of CD4-positive, alpha-beta T cell proliferation;","GO:0005634|nucleus;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005902|microvillus;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0031258|lamellipodium membrane;GO:0032991|protein-containing complex;GO:0035692|macrophage migration inhibitory factor receptor complex;GO:0042995|cell projection;","GO:0004888|transmembrane signaling receptor activity;GO:0004896|cytokine receptor activity;GO:0005114|type II transforming growth factor beta receptor binding;GO:0005154|epidermal growth factor receptor binding;GO:0005515|protein binding;GO:0005540|hyaluronic acid binding;GO:0019901|protein kinase binding;GO:0019955|cytokine binding;GO:0051219|phosphoprotein binding;","K06256","CD44; CD44 antigen"]
["ENSRNOG00000057443",274,17.62654006,1459,94.19575324,0.187126696,-2.417912704,{"v":3.9429e-195,"d":"3.94E-195"},{"v":4.5586e-194,"d":"4.56E-194"},"down","yes","Nos2","protein_coding","chr10:63815308-63851210:+","gi|564373342|ref|XP_006247011.1|",6175,0,"PREDICTED: nitric oxide synthase, inducible-like [Rattus norvegicus]","gi|430718|gb|U03699.1|RNU03699",3784,0,"Rattus norvegicus Sprague Dawley inducible nitric oxide synthase (NOS) mRNA, complete cds","Q06518",2306,0,"Nitric oxide synthase, inducible","BH0823",346,{"v":1e-106,"d":"1.00E-106"},"COG4362","pfam02898","NO_synthase","Nitric oxide synthase, oxygenase domain.","GO:0001666|response to hypoxia;GO:0001935|endothelial cell proliferation;GO:0001974|blood vessel remodeling;GO:0006527|arginine catabolic process;GO:0006801|superoxide metabolic process;GO:0006809|nitric oxide biosynthetic process;GO:0006954|inflammatory response;GO:0007165|signal transduction;GO:0007199|G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger;GO:0007263|nitric oxide mediated signal transduction;GO:0007568|aging;GO:0007623|circadian rhythm;GO:0008016|regulation of heart contraction;GO:0008217|regulation of blood pressure;GO:0009612|response to mechanical stimulus;GO:0009617|response to bacterium;GO:0009725|response to hormone;GO:0010629|negative regulation of gene expression;GO:0014823|response to activity;GO:0016137|glycoside metabolic process;GO:0018119|peptidyl-cysteine S-nitrosylation;GO:0019934|cGMP-mediated signaling;GO:0031284|positive regulation of guanylate cyclase activity;GO:0032310|prostaglandin secretion;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0034612|response to tumor necrosis factor;GO:0035556|intracellular signal transduction;GO:0035902|response to immobilization stress;GO:0042060|wound healing;GO:0042127|regulation of cell proliferation;GO:0042177|negative regulation of protein catabolic process;GO:0042742|defense response to bacterium;GO:0043065|positive regulation of apoptotic process;GO:0045776|negative regulation of blood pressure;GO:0048384|retinoic acid receptor signaling pathway;GO:0050796|regulation of insulin secretion;GO:0050829|defense response to Gram-negative bacterium;GO:0051712|positive regulation of killing of cells of other organism;GO:0071222|cellular response to lipopolysaccharide;GO:0071285|cellular response to lithium ion;GO:0071305|cellular response to vitamin D;GO:0071345|cellular response to cytokine stimulus;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071407|cellular response to organic cyclic compound;GO:0071461|cellular response to redox state;GO:0071466|cellular response to xenobiotic stimulus;GO:0071548|response to dexamethasone;GO:1900015|regulation of cytokine production involved in inflammatory response;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005777|peroxisome;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0012506|vesicle membrane;GO:0030863|cortical cytoskeleton;GO:0048471|perinuclear region of cytoplasm;","GO:0003779|actin binding;GO:0004517|nitric-oxide synthase activity;GO:0005515|protein binding;GO:0005516|calmodulin binding;GO:0008013|beta-catenin binding;GO:0008603|cAMP-dependent protein kinase regulator activity;GO:0010181|FMN binding;GO:0016491|oxidoreductase activity;GO:0019901|protein kinase binding;GO:0020037|heme binding;GO:0034617|tetrahydrobiopterin binding;GO:0034618|arginine binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0045296|cadherin binding;GO:0046872|metal ion binding;GO:0050660|flavin adenine dinucleotide binding;GO:0050661|NADP binding;GO:0050998|nitric-oxide synthase binding;GO:0051879|Hsp90 protein binding;","K13241","NOS2; nitric-oxide synthase, inducible [EC:1.14.13.39]"]
["ENSRNOG00000021255",449,28.88436674,1817,117.308899,0.246224856,-2.021951689,{"v":6.1492e-195,"d":"6.15E-195"},{"v":7.0949e-194,"d":"7.09E-194"},"down","yes","Smox","protein_coding","chr3:118731900-118765710:+","gi|198442863|ref|NP_001128326.1|",2894,0,"spermine oxidase [Rattus norvegicus]","gi|198442862|ref|NM_001134854.1|",2256,0,"Rattus norvegicus spermine oxidase (Smox), mRNA","Q99K82",1096,0,"Spermine oxidase",".",".",".",".","pfam01593","Amino_oxidase","Flavin containing amine oxidoreductase. This family consists of various amine oxidases, including maze polyamine oxidase (PAO) and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.","GO:0006598|polyamine catabolic process;GO:0046208|spermine catabolic process;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0031965|nuclear membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0016491|oxidoreductase activity;GO:0046592|polyamine oxidase activity;","K12259","SMOX, PAO5; spermine oxidase [EC:1.5.3.16 1.5.3.-]"]
["ENSRNOG00000043007",1431,92.05685704,3458,223.2549107,0.412339674,-1.278094816,{"v":7.065e-192,"d":"7.07E-192"},{"v":8.0701e-191,"d":"8.07E-191"},"down","yes","Rcn3","protein_coding","chr1:95564380-95573725:-","gi|56744249|ref|NP_001008694.1|",1685,0,"reticulocalbin-3 precursor [Rattus norvegicus]","gi|158749645|ref|NM_001008694.2|",1160,0,"Rattus norvegicus reticulocalbin 3 (Rcn3), mRNA","Q8BH97",645,0,"Reticulocalbin-3",".",".",".",".","pfam13499","EF-hand_7","EF-hand domain pair.","GO:0009306|protein secretion;GO:0010952|positive regulation of peptidase activity;GO:0015031|protein transport;GO:0032964|collagen biosynthetic process;GO:0036503|ERAD pathway;GO:0043129|surfactant homeostasis;GO:0051896|regulation of protein kinase B signaling;GO:0055091|phospholipid homeostasis;GO:0060428|lung epithelium development;","GO:0005783|endoplasmic reticulum;GO:0005788|endoplasmic reticulum lumen;GO:0043231|intracellular membrane-bounded organelle;","GO:0005509|calcium ion binding;","K23900","RCN3; reticulocalbin-3"]
["ENSRNOG00000006548",857,55.13118552,2534,163.5997524,0.336988197,-1.569230034,{"v":1.308E-191,"d":"1.31E-191"},{"v":1.4882e-190,"d":"1.49E-190"},"down","yes","Mrc2","protein_coding","chr10:90261394-90322856:+","gi|149054516|gb|EDM06333.1|",7583,0,"collagen-binding factor Endo180 [Rattus norvegicus]","gi|672069851|ref|XM_006247631.2|",5347,0,"PREDICTED: Rattus norvegicus mannose receptor, C type 2 (Mrc2), transcript variant X1, mRNA","Q4TU93",2893,0,"C-type mannose receptor 2",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0006897|endocytosis;GO:0030574|collagen catabolic process;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0005518|collagen binding;GO:0030246|carbohydrate binding;GO:0038023|signaling receptor activity;","K06560","MRC, CD206, CD280; mannose receptor, C type"]
["ENSRNOG00000017874",200,12.86608764,1274,82.2518092,0.156423157,-2.676473992,{"v":6.3068e-191,"d":"6.31E-191"},{"v":7.1468e-190,"d":"7.15E-190"},"down","yes","Cd53","protein_coding","chr2:194352139-194399657:-","gi|148669936|gb|EDL01883.1|",1016,{"v":4e-132,"d":"4.00E-132"},"CD53 antigen, isoform CRA_a, partial [Mus musculus]","gi|401709945|ref|NM_012523.2|",1699,0,"Rattus norvegicus Cd53 molecule (Cd53), mRNA","P24485",392,{"v":2E-132,"d":"2.00E-132"},"Leukocyte surface antigen CD53",".",".",".",".","pfam00335","Tetraspannin","Tetraspanin family.","GO:0040008|regulation of growth;GO:1901741|positive regulation of myoblast fusion;","GO:0001772|immunological synapse;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005911|cell-cell junction;GO:0009986|cell surface;","GO:0042802|identical protein binding;","K06489","CD53, MOX44, TSPAN25; CD53 antigen"]
["ENSRNOG00000001645",1091,70.18450806,2915,188.1978209,0.372929441,-1.423025401,{"v":1.0751E-190,"d":"1.08E-190"},{"v":1.2159E-189,"d":"1.22E-189"},"down","yes","Filip1l","protein_coding","chr11:42940467-43177415:-","gi|672025961|ref|XP_008774774.1|",5565,0,"PREDICTED: filamin A-interacting protein 1-like isoform X1 [Rattus norvegicus]","gi|672070935|ref|XM_008768653.1|",3744,0,"PREDICTED: Rattus norvegicus filamin A interacting protein 1-like (Filip1l), transcript variant X2, mRNA","Q6P6L0",1924,0,"Filamin A-interacting protein 1-like",".",".",".",".","pfam09727","CortBP2","Cortactin-binding protein-2. This entry is the first approximately 250 residues of cortactin-binding protein 2. In addition to being a positional candidate for autism this protein is expressed at highest levels in the brain in humans. The human protein has six associated ankyrin repeat domains pfam00023 towards the C-terminus which act as protein-protein interaction domains.",".",".",".",".","."]
["ENSRNOG00000013820",47,3.023530595,871,56.23337976,0.053767542,-4.217120676,{"v":5.3689e-190,"d":"5.37E-190"},{"v":6.048e-189,"d":"6.05E-189"},"down","yes","Tnfrsf14","protein_coding","chr5:165484262-165493703:-","gi|564354542|ref|XP_006239648.1|",1218,{"v":6e-154,"d":"6.00E-154"},"PREDICTED: tumor necrosis factor receptor superfamily member 14 isoform X1 [Rattus norvegicus]","gi|672054990|ref|XR_354472.2|",2791,0,"PREDICTED: Rattus norvegicus tumor necrosis factor receptor superfamily, member 14 (Tnfrsf14), transcript variant X2, misc_RNA","Q92956",177,{"v":2e-47,"d":"2.00E-47"},"Tumor necrosis factor receptor superfamily member 14",".",".",".",".","pfam00020","TNFR_c6","TNFR/NGFR cysteine-rich region.","GO:0002720|positive regulation of cytokine production involved in immune response;GO:0008150|biological_process;GO:0031295|T cell costimulation;GO:0046642|negative regulation of alpha-beta T cell proliferation;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:1905675|negative regulation of adaptive immune memory response;GO:2000406|positive regulation of T cell migration;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0019955|cytokine binding;GO:0031625|ubiquitin protein ligase binding;","K05152","TNFRSF14, HVEM, CD270; tumor necrosis factor receptor superfamily member 14"]
["ENSRNOG00000006940",89,5.725408998,990,63.91624106,0.089576748,-3.480731903,{"v":6.7759e-190,"d":"6.78E-190"},{"v":7.6179e-189,"d":"7.62E-189"},"down","yes","Ncf4","protein_coding","chr7:109826020-109843389:+","gi|187937026|ref|NP_001120776.1|",1771,0,"neutrophil cytosol factor 4 [Rattus norvegicus]","gi|187937025|ref|NM_001127304.1|",1496,0,"Rattus norvegicus neutrophil cytosolic factor 4 (Ncf4), mRNA","P97369",671,0,"Neutrophil cytosol factor 4",".",".",".",".","pfam00787","PX","PX domain. PX domains bind to phosphoinositides.","GO:0006909|phagocytosis;GO:0042554|superoxide anion generation;GO:0045730|respiratory burst;GO:0050790|regulation of catalytic activity;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0010008|endosome membrane;GO:0016020|membrane;GO:0043020|NADPH oxidase complex;","GO:0016176|superoxide-generating NADPH oxidase activator activity;GO:0032266|phosphatidylinositol-3-phosphate binding;","K08012","NCF4, P40PHOX; neutrophil cytosolic factor 4"]
["ENSRNOG00000017500",441,28.36972324,1771,114.3390534,0.248119277,-2.010894271,{"v":1.0186e-188,"d":"1.02E-188"},{"v":1.1363E-187,"d":"1.14E-187"},"down","yes","Mtss2","protein_coding","chr19:38693194-38713507:+","gi|672084872|ref|XP_008770735.1|",2683,0,"PREDICTED: MTSS1-like protein isoform X2 [Rattus norvegicus]","gi|672084871|ref|XM_008772513.1|",3340,0,"PREDICTED: Rattus norvegicus metastasis suppressor 1-like (Mtss1l), transcript variant X2, mRNA","Q6P9S0",975,0,"MTSS1-like protein",".",".",".",".","pfam08397","IMD","IRSp53/MIM homology domain. The N-terminal predicted helical stretch of the insulin receptor tyrosine kinase substrate p53 (IRSp53) is an evolutionary conserved F-actin bundling domain involved in filopodium formation. The domain has been named IMD after the IRSp53 and missing in metastasis (MIM) proteins in which it occurs. Filopodium-inducing IMD activity is regulated by Cdc42 and Rac1 and is SH3-independent.","GO:0007009|plasma membrane organization;GO:0030031|cell projection assembly;GO:0036120|cellular response to platelet-derived growth factor stimulus;GO:0061024|membrane organization;GO:0090630|activation of GTPase activity;GO:0097178|ruffle assembly;GO:0097581|lamellipodium organization;","GO:0001726|ruffle;GO:0005886|plasma membrane;GO:0015629|actin cytoskeleton;GO:0030027|lamellipodium;GO:0030864|cortical actin cytoskeleton;GO:0031235|intrinsic component of the cytoplasmic side of the plasma membrane;GO:0032587|ruffle membrane;","GO:0003779|actin binding;GO:0003785|actin monomer binding;GO:0005096|GTPase activator activity;GO:0005543|phospholipid binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0031267|small GTPase binding;","K20128","MTSS1; metastasis suppressor protein 1"]
["ENSRNOG00000042139",80,5.146435055,955,61.65657597,0.083469362,-3.582609447,{"v":2.3389e-187,"d":"2.34E-187"},{"v":2.6039E-186,"d":"2.60E-186"},"down","yes","Clec4a1","protein_coding","chr4:156173894-156186008:+","gi|54312106|ref|NP_001005890.1|",1120,{"v":4E-150,"d":"4.00E-150"},"C-type lectin domain family 4, member A1 [Rattus norvegicus]","gi|70778852|ref|NM_001005890.2|",1199,0,"Rattus norvegicus C-type lectin domain family 4, member A1 (Clec4a1), mRNA","Q9UMR7",201,{"v":3e-60,"d":"3.00E-60"},"C-type lectin domain family 4 member A",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type",".","GO:0016021|integral component of membrane;","GO:0030246|carbohydrate binding;","K10057","CLEC4A, CD367; C-type lectin domain family 4 member A"]
["ENSRNOG00000013014",755,48.56948083,2332,150.5582567,0.32259593,-1.632199858,{"v":1.0504e-186,"d":"1.05E-186"},{"v":1.1649E-185,"d":"1.16E-185"},"down","yes","Cyba","protein_coding","chr19:50487597-50495721:-","gi|13162359|ref|NP_077074.1|",819,{"v":9e-108,"d":"9.00E-108"},"cytochrome b-245 light chain [Rattus norvegicus]","gi|13162358|ref|NM_024160.1|",656,0,"Rattus norvegicus cytochrome b-245, alpha polypeptide (Cyba), mRNA","Q62737",320,{"v":3e-109,"d":"3.00E-109"},"Cytochrome b-245 light chain",".",".",".",".","pfam05038","Cytochrom_B558a","Cytochrome Cytochrome b558 alpha-subunit. Cytochrome b-245 light chain (p22-phox) is one of the key electron transfer elements of the NADPH oxidase in phagocytes.","GO:0001666|response to hypoxia;GO:0001938|positive regulation of endothelial cell proliferation;GO:0003106|negative regulation of glomerular filtration by angiotensin;GO:0006801|superoxide metabolic process;GO:0006954|inflammatory response;GO:0009410|response to xenobiotic stimulus;GO:0014823|response to activity;GO:0014895|smooth muscle hypertrophy;GO:0017004|cytochrome complex assembly;GO:0022900|electron transport chain;GO:0030307|positive regulation of cell growth;GO:0031667|response to nutrient levels;GO:0032755|positive regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032930|positive regulation of superoxide anion generation;GO:0033864|positive regulation of NAD(P)H oxidase activity;GO:0034137|positive regulation of toll-like receptor 2 signaling pathway;GO:0042554|superoxide anion generation;GO:0045087|innate immune response;GO:0045730|respiratory burst;GO:0045777|positive regulation of blood pressure;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0050665|hydrogen peroxide biosynthetic process;GO:0050766|positive regulation of phagocytosis;GO:0051279|regulation of release of sequestered calcium ion into cytosol;GO:0070257|positive regulation of mucus secretion;GO:0070555|response to interleukin-1;GO:0071230|cellular response to amino acid stimulus;GO:0071260|cellular response to mechanical stimulus;GO:0071310|cellular response to organic substance;GO:0071333|cellular response to glucose stimulus;GO:0071356|cellular response to tumor necrosis factor;GO:0071407|cellular response to organic cyclic compound;GO:0071480|cellular response to gamma radiation;GO:0072593|reactive oxygen species metabolic process;GO:1900426|positive regulation of defense response to bacterium;GO:1903428|positive regulation of reactive oxygen species biosynthetic process;GO:1904044|response to aldosterone;GO:1904385|cellular response to angiotensin;GO:1904845|cellular response to L-glutamine;GO:2000376|positive regulation of oxygen metabolic process;","GO:0001725|stress fiber;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005794|Golgi apparatus;GO:0005925|focal adhesion;GO:0016324|apical plasma membrane;GO:0030425|dendrite;GO:0043020|NADPH oxidase complex;GO:0043025|neuronal cell body;GO:0097038|perinuclear endoplasmic reticulum;","GO:0005515|protein binding;GO:0009055|electron transfer activity;GO:0016175|superoxide-generating NADPH oxidase activity;GO:0017124|SH3 domain binding;GO:0020037|heme binding;GO:0046872|metal ion binding;GO:0046982|protein heterodimerization activity;","K08009","CYBA, P22PHOX; cytochrome b-245, alpha polypeptide"]
["ENSRNOG00000016968",289,18.59149664,1427,92.12977373,0.201796834,-2.309024556,{"v":6.7811e-181,"d":"6.78E-181"},{"v":7.3212e-180,"d":"7.32E-180"},"down","yes","Gramd4","protein_coding","chr7:117150374-117224053:+","gi|392349662|ref|XP_235571.6|",2936,0,"PREDICTED: GRAM domain-containing protein 4 isoform X1 [Rattus norvegicus]","gi|672060458|ref|XM_235571.8|",3976,0,"PREDICTED: Rattus norvegicus GRAM domain containing 4 (Gramd4), transcript variant X1, mRNA","Q8CB44",1125,0,"GRAM domain-containing protein 4",".",".",".",".","pfam02893","GRAM","GRAM domain. The GRAM domain is found in in glucosyltransferases, myotubularins and other putative membrane-associated proteins.","GO:0006915|apoptotic process;GO:0034164|negative regulation of toll-like receptor 9 signaling pathway;GO:0043280|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;","GO:0005739|mitochondrion;GO:0016021|integral component of membrane;",".","K23554","GRAMD4; GRAM domain-containing protein 4"]
["ENSRNOG00000023338",227,14.60300947,1284,82.8974278,0.17615757,-2.505061619,{"v":5.1383e-179,"d":"5.14E-179"},{"v":5.4853e-178,"d":"5.49E-178"},"down","yes","Tspan2","protein_coding","chr2:190177741-190219660:+","gi|12018246|ref|NP_072111.1|",982,{"v":4e-120,"d":"4.00E-120"},"tetraspanin-2 [Rattus norvegicus]","gi|12018245|ref|NM_022589.1|",3746,0,"Rattus norvegicus tetraspanin 2 (Tspan2), mRNA","Q9JJW1",382,{"v":1e-121,"d":"1.00E-121"},"Tetraspanin-2",".",".",".",".","pfam00335","Tetraspannin","Tetraspanin family.","GO:0006954|inflammatory response;GO:0007420|brain development;GO:0014002|astrocyte development;GO:0014005|microglia development;GO:0042552|myelination;GO:0048709|oligodendrocyte differentiation;GO:0061564|axon development;","GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0043209|myelin sheath;",".","K17354","TSPAN2; tetraspanin-2"]
["ENSRNOG00000002548",25,1.608260955,767,49.51894636,0.032477689,-4.944407197,{"v":7.1169e-179,"d":"7.12E-179"},{"v":7.5833e-178,"d":"7.58E-178"},"down","yes","Tnn","protein_coding","chr13:72319155-72408156:-","gi|312922379|ref|NP_001100659.2|",8104,0,"tenascin-N precursor [Rattus norvegicus]","gi|672074420|ref|XM_008769642.1|",6185,0,"PREDICTED: Rattus norvegicus tenascin N (Tnn), transcript variant X1, mRNA","Q80Z71",3039,0,"Tenascin-N",".",".",".",".","pfam00147","Fibrinogen_C","Fibrinogen beta and gamma chains, C-terminal globular domain.","GO:0001764|neuron migration;GO:0002076|osteoblast development;GO:0007160|cell-matrix adhesion;GO:0007409|axonogenesis;GO:0033689|negative regulation of osteoblast proliferation;GO:0045668|negative regulation of osteoblast differentiation;GO:0070593|dendrite self-avoidance;GO:1905240|negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation;GO:1990138|neuron projection extension;GO:2001223|negative regulation of neuron migration;","GO:0005615|extracellular space;GO:0009986|cell surface;GO:0031012|extracellular matrix;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0062023|collagen-containing extracellular matrix;GO:0097442|CA3 pyramidal cell dendrite;GO:1990026|hippocampal mossy fiber expansion;","GO:0005178|integrin binding;GO:0042802|identical protein binding;","K06252","TN; tenascin"]
["ENSRNOG00000046254",90,5.789739437,946,61.07551923,0.094796401,-3.399023896,{"v":3.8933E-178,"d":"3.89E-178"},{"v":4.1331e-177,"d":"4.13E-177"},"down","yes","Adgre1","protein_coding","chr9:2242474-2398000:+","gi|56090594|ref|NP_001007558.1|",4972,0,"adhesion G protein-coupled receptor E2 precursor [Rattus norvegicus]","gi|56090593|ref|NM_001007557.1|",3226,0,"Rattus norvegicus adhesion G protein-coupled receptor E1 (Adgre1), mRNA","Q5Y4N8",1919,0,"Adhesion G protein-coupled receptor E2",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0002250|adaptive immune response;GO:0007166|cell surface receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0071944|cell periphery;","GO:0004930|G protein-coupled receptor activity;GO:0005509|calcium ion binding;","K04591","ADGRE1, EMR1; adhesion G protein-coupled receptor E1"]
["ENSRNOG00000049976",117,7.526661268,1015,65.53028755,0.114857748,-3.122079912,{"v":1.6656e-177,"d":"1.67E-177"},{"v":1.7616E-176,"d":"1.76E-176"},"down","yes","Gzmbl2","protein_coding","chr15:30173603-30346814:-","gi|119851007|gb|AAI27476.1|",1175,{"v":3e-154,"d":"3.00E-154"},"Gzmb protein [Rattus norvegicus]","gi|119851006|gb|BC127475.1|",2052,0,"Rattus norvegicus granzyme B, mRNA (cDNA clone MGC:156565 IMAGE:7124652), complete cds","P18291",364,{"v":1E-119,"d":"1.00E-119"},"Granzyme B","mlr3307",53.1,1e-06,"COG5640","pfam00089","Trypsin","Trypsin.","GO:0001913|T cell mediated cytotoxicity;GO:0006508|proteolysis;GO:0006915|apoptotic process;GO:0010942|positive regulation of cell death;GO:0017148|negative regulation of translation;GO:0019835|cytolysis;GO:0042267|natural killer cell mediated cytotoxicity;GO:0051603|proteolysis involved in cellular protein catabolic process;GO:0060545|positive regulation of necroptotic process;GO:0070269|pyroptosis;","GO:0005576|extracellular region;GO:0005737|cytoplasm;GO:0005769|early endosome;GO:0043231|intracellular membrane-bounded organelle;GO:0044194|cytolytic granule;","GO:0004252|serine-type endopeptidase activity;GO:0005515|protein binding;GO:0008236|serine-type peptidase activity;","K01353","GZMB; granzyme B [EC:3.4.21.79]"]
["ENSRNOG00000051548",259,16.66158349,1342,86.64201566,0.192303738,-2.378541288,{"v":2.8394e-176,"d":"2.84E-176"},{"v":2.9865E-175,"d":"2.99E-175"},"down","yes","Lmod1","protein_coding","chr13:46754033-46794900:+","gi|672074114|ref|XP_008767784.1|",2320,0,"PREDICTED: leiomodin-1 isoform X1 [Rattus norvegicus]","gi|672074113|ref|XM_008769562.1|",2672,0,"PREDICTED: Rattus norvegicus leiomodin 1 (smooth muscle) (Lmod1), transcript variant X1, mRNA","A0A0G2K0D3",898,0,"Leiomodin-1",".",".",".",".","pfam03250","Tropomodulin","Tropomodulin. Tropomodulin is a novel tropomyosin regulatory protein that binds to the end of erythrocyte tropomyosin and blocks head-to-tail association of tropomyosin along actin filaments. Limited proteolysis shows this protein is composed of two domains. The amino terminal domain contains the tropomyosin binding function.","GO:0030838|positive regulation of actin filament polymerization;GO:0045010|actin nucleation;GO:0051694|pointed-end actin filament capping;","GO:0005829|cytosol;GO:0005884|actin filament;GO:0030016|myofibril;GO:0030017|sarcomere;","GO:0003779|actin binding;","K22030","LMOD; leiomodin"]
["ENSRNOG00000004649",132,8.49161784,1047,67.59626706,0.125622586,-2.992832227,{"v":5.5621e-176,"d":"5.56E-176"},{"v":5.8395e-175,"d":"5.84E-175"},"down","yes","Il1b","protein_coding","chr3:116577010-116583415:-","gi|158186736|ref|NP_113700.2|",1243,{"v":6e-165,"d":"6.00E-165"},"interleukin-1 beta precursor [Rattus norvegicus]","gi|158186735|ref|NM_031512.2|",1209,0,"Rattus norvegicus interleukin 1 beta (Il1b), mRNA","Q63264",479,{"v":4E-165,"d":"4.00E-165"},"Interleukin-1 beta",".",".",".",".","pfam00340","IL1","Interleukin-1 / 18. This family includes interleukin-1 and interleukin-18.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0000165|MAPK cascade;GO:0001660|fever generation;GO:0001666|response to hypoxia;GO:0001934|positive regulation of protein phosphorylation;GO:0002439|chronic inflammatory response to antigenic stimulus;GO:0002526|acute inflammatory response;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007584|response to nutrient;GO:0007611|learning or memory;GO:0007613|memory;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0009408|response to heat;GO:0009410|response to xenobiotic stimulus;GO:0009743|response to carbohydrate;GO:0010193|response to ozone;GO:0010243|response to organonitrogen compound;GO:0010332|response to gamma radiation;GO:0010573|vascular endothelial growth factor production;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010718|positive regulation of epithelial to mesenchymal transition;GO:0010829|negative regulation of glucose transmembrane transport;GO:0010942|positive regulation of cell death;GO:0014050|negative regulation of glutamate secretion;GO:0014070|response to organic cyclic compound;GO:0019221|cytokine-mediated signaling pathway;GO:0030213|hyaluronan biosynthetic process;GO:0030335|positive regulation of cell migration;GO:0030593|neutrophil chemotaxis;GO:0030728|ovulation;GO:0030730|sequestering of triglyceride;GO:0031394|positive regulation of prostaglandin biosynthetic process;GO:0031622|positive regulation of fever generation;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0032308|positive regulation of prostaglandin secretion;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0032722|positive regulation of chemokine production;GO:0032725|positive regulation of granulocyte macrophage colony-stimulating factor production;GO:0032729|positive regulation of interferon-gamma production;GO:0032743|positive regulation of interleukin-2 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0032874|positive regulation of stress-activated MAPK cascade;GO:0033092|positive regulation of immature T cell proliferation in thymus;GO:0033198|response to ATP;GO:0033280|response to vitamin D;GO:0033591|response to L-ascorbic acid;GO:0034116|positive regulation of heterotypic cell-cell adhesion;GO:0035176|social behavior;GO:0035234|ectopic germ cell programmed cell death;GO:0035505|positive regulation of myosin light chain kinase activity;GO:0035634|response to stilbenoid;GO:0035902|response to immobilization stress;GO:0042060|wound healing;GO:0042102|positive regulation of T cell proliferation;GO:0043065|positive regulation of apoptotic process;GO:0043122|regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043278|response to morphine;GO:0043406|positive regulation of MAP kinase activity;GO:0043407|negative regulation of MAP kinase activity;GO:0043434|response to peptide hormone;GO:0043491|protein kinase B signaling;GO:0043507|positive regulation of JUN kinase activity;GO:0043525|positive regulation of neuron apoptotic process;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0045471|response to ethanol;GO:0045665|negative regulation of neuron differentiation;GO:0045687|positive regulation of glial cell differentiation;GO:0045766|positive regulation of angiogenesis;GO:0045833|negative regulation of lipid metabolic process;GO:0045840|positive regulation of mitotic nuclear division;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045917|positive regulation of complement activation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046330|positive regulation of JNK cascade;GO:0046627|negative regulation of insulin receptor signaling pathway;GO:0048143|astrocyte activation;GO:0048711|positive regulation of astrocyte differentiation;GO:0050691|regulation of defense response to virus by host;GO:0050729|positive regulation of inflammatory response;GO:0050766|positive regulation of phagocytosis;GO:0050767|regulation of neurogenesis;GO:0050768|negative regulation of neurogenesis;GO:0050796|regulation of insulin secretion;GO:0050805|negative regulation of synaptic transmission;GO:0050900|leukocyte migration;GO:0050995|negative regulation of lipid catabolic process;GO:0050996|positive regulation of lipid catabolic process;GO:0050999|regulation of nitric-oxide synthase activity;GO:0051044|positive regulation of membrane protein ectodomain proteolysis;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051384|response to glucocorticoid;GO:0051781|positive regulation of cell division;GO:0060252|positive regulation of glial cell proliferation;GO:0060559|positive regulation of calcidiol 1-monooxygenase activity;GO:0070164|negative regulation of adiponectin secretion;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070487|monocyte aggregation;GO:0070498|interleukin-1-mediated signaling pathway;GO:0070555|response to interleukin-1;GO:0071222|cellular response to lipopolysaccharide;GO:0071236|cellular response to antibiotic;GO:0071260|cellular response to mechanical stimulus;GO:0071310|cellular response to organic substance;GO:0071333|cellular response to glucose stimulus;GO:0071396|cellular response to lipid;GO:0071398|cellular response to fatty acid;GO:0071407|cellular response to organic cyclic compound;GO:0071466|cellular response to xenobiotic stimulus;GO:0071548|response to dexamethasone;GO:0071639|positive regulation of monocyte chemotactic protein-1 production;GO:0090023|positive regulation of neutrophil chemotaxis;GO:0097192|extrinsic apoptotic signaling pathway in absence of ligand;GO:1900745|positive regulation of p38MAPK cascade;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1902680|positive regulation of RNA biosynthetic process;GO:1903140|regulation of establishment of endothelial barrier;GO:1903597|negative regulation of gap junction assembly;GO:2000173|negative regulation of branching morphogenesis of a nerve;GO:2000178|negative regulation of neural precursor cell proliferation;GO:2000556|positive regulation of T-helper 1 cell cytokine production;GO:2001240|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005764|lysosome;GO:0005829|cytosol;GO:0030141|secretory granule;GO:0031982|vesicle;","GO:0005125|cytokine activity;GO:0005149|interleukin-1 receptor binding;GO:0005178|integrin binding;GO:0019904|protein domain specific binding;","K04519","IL1B; interleukin 1 beta"]
["ENSRNOG00000014081",37,2.380226213,787,50.81018355,0.046845456,-4.415947079,{"v":7.2984e-176,"d":"7.30E-176"},{"v":7.6344e-175,"d":"7.63E-175"},"down","yes","Nmur2","protein_coding","chr10:40166226-40182078:-","gi|149052674|gb|EDM04491.1|",2161,0,"neuromedin U receptor 2 [Rattus norvegicus]","gi|399154158|ref|NM_022275.3|",3302,0,"Rattus norvegicus neuromedin U receptor 2 (Nmur2), mRNA","Q9ESQ4",752,0,"Neuromedin-U receptor 2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0002023|reduction of food intake in response to dietary excess;GO:0006816|calcium ion transport;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007218|neuropeptide signaling pathway;GO:0007417|central nervous system development;GO:0007625|grooming behavior;GO:0015698|inorganic anion transport;GO:0043006|activation of phospholipase A2 activity by calcium-mediated signaling;GO:0048016|inositol phosphate-mediated signaling;GO:0048265|response to pain;GO:0050482|arachidonic acid secretion;GO:0051930|regulation of sensory perception of pain;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0001607|neuromedin U receptor activity;GO:0004930|G protein-coupled receptor activity;GO:0005229|intracellular calcium activated chloride channel activity;GO:0005525|GTP binding;GO:0008188|neuropeptide receptor activity;GO:0042924|neuromedin U binding;","K05053","NMUR2; neuromedin U receptor 2"]
["ENSRNOG00000059801",610,39.24156729,2011,129.8338998,0.302244386,-1.726212553,{"v":1.8977E-174,"d":"1.90E-174"},1.96E-173,"down","yes","Lima1","protein_coding","chr7:130901717-131001473:-","gi|564400249|ref|XP_006257416.1|",3827,0,"PREDICTED: LIM domain and actin-binding protein 1 isoform X2 [Rattus norvegicus]","gi|672059939|ref|XM_006257354.2|",4645,0,"PREDICTED: Rattus norvegicus LIM domain and actin binding 1 (Lima1), transcript variant X1, mRNA","Q9ERG0",1258,0,"LIM domain and actin-binding protein 1",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.","GO:0008203|cholesterol metabolic process;GO:0016477|cell migration;GO:0030299|intestinal cholesterol absorption;GO:0030835|negative regulation of actin filament depolymerization;GO:0031529|ruffle organization;GO:0042632|cholesterol homeostasis;GO:0051017|actin filament bundle assembly;","GO:0001725|stress fiber;GO:0001726|ruffle;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005903|brush border;GO:0005925|focal adhesion;GO:0015629|actin cytoskeleton;GO:0031526|brush border membrane;GO:0032154|cleavage furrow;","GO:0003785|actin monomer binding;GO:0046872|metal ion binding;GO:0051015|actin filament binding;","K23026","LIMA1, EPLIN; LIM domain and actin-binding protein 1"]
["ENSRNOG00000011153",715,45.9962633,2191,141.4550345,0.325165262,-1.620754957,{"v":8.5228e-174,"d":"8.52E-174"},{"v":8.7863e-173,"d":"8.79E-173"},"down","yes","Il17ra","protein_coding","chr4:153667534-153690174:+","gi|255708388|ref|NP_001101353.2|",4194,0,"interleukin-17 receptor A [Rattus norvegicus]","gi|255708387|ref|NM_001107883.2|",3845,0,"Rattus norvegicus interleukin 17 receptor A (Il17ra), mRNA","Q60943",1364,0,"Interleukin-17 receptor A",".",".",".",".","pfam08357","SEFIR","SEFIR domain. This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain (pfam01582), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways.","GO:0009615|response to virus;GO:0030163|protein catabolic process;GO:0032736|positive regulation of interleukin-13 production;GO:0032747|positive regulation of interleukin-23 production;GO:0032754|positive regulation of interleukin-5 production;GO:0032755|positive regulation of interleukin-6 production;GO:0050729|positive regulation of inflammatory response;GO:0050832|defense response to fungus;GO:0071345|cellular response to cytokine stimulus;GO:0071621|granulocyte chemotaxis;GO:0072537|fibroblast activation;GO:0072538|T-helper 17 type immune response;GO:0097400|interleukin-17-mediated signaling pathway;GO:1900017|positive regulation of cytokine production involved in inflammatory response;GO:2000340|positive regulation of chemokine (C-X-C motif) ligand 1 production;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0005102|signaling receptor binding;GO:0030368|interleukin-17 receptor activity;","K05164","IL17RA, CD217; interleukin 17 receptor A"]
["ENSRNOG00000014034",450,28.94869718,1709,110.3362182,0.262368039,-1.93033611,{"v":9.6747e-173,"d":"9.67E-173"},{"v":9.9024e-172,"d":"9.90E-172"},"down","yes","Olfml2a","protein_coding","chr3:22688598-22717909:+","gi|564340633|ref|XP_006234136.1|",3103,0,"PREDICTED: olfactomedin-like protein 2A isoform X1 [Rattus norvegicus]","gi|672045234|ref|XM_006234074.2|",5851,0,"PREDICTED: Rattus norvegicus olfactomedin-like 2A (Olfml2a), transcript variant X1, mRNA","Q8BHP7",1113,0,"Olfactomedin-like protein 2A",".",".",".",".","pfam02191","OLF","Olfactomedin-like domain.","GO:0030198|extracellular matrix organization;","GO:0031012|extracellular matrix;","GO:0042802|identical protein binding;GO:0050840|extracellular matrix binding;","K25449","OLFML2; olfactomedin-like protein 2"]
["ENSRNOG00000001821",11,0.70763482,725,46.80734825,0.015118028,-6.047586186,{"v":1.1974E-172,"d":"1.20E-172"},{"v":1.2212e-171,"d":"1.22E-171"},"down","yes","Adipoq","protein_coding","chr11:77721912-77735564:-","gi|21426809|ref|NP_653345.1|",1227,{"v":8e-165,"d":"8.00E-165"},"adiponectin precursor [Rattus norvegicus]","gi|326633221|ref|NM_144744.3|",1487,0,"Rattus norvegicus adiponectin, C1Q and collagen domain containing (Adipoq), mRNA","Q60994",427,{"v":1E-146,"d":"1.00E-146"},"Adiponectin",".",".",".",".","pfam00386","C1q","C1q domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.","GO:0001666|response to hypoxia;GO:0001934|positive regulation of protein phosphorylation;GO:0006006|glucose metabolic process;GO:0006635|fatty acid beta-oxidation;GO:0007165|signal transduction;GO:0007584|response to nutrient;GO:0007623|circadian rhythm;GO:0009410|response to xenobiotic stimulus;GO:0009617|response to bacterium;GO:0009744|response to sucrose;GO:0009749|response to glucose;GO:0009967|positive regulation of signal transduction;GO:0010467|gene expression;GO:0010642|negative regulation of platelet-derived growth factor receptor signaling pathway;GO:0010739|positive regulation of protein kinase A signaling;GO:0010745|negative regulation of macrophage derived foam cell differentiation;GO:0010804|negative regulation of tumor necrosis factor-mediated signaling pathway;GO:0010875|positive regulation of cholesterol efflux;GO:0010906|regulation of glucose metabolic process;GO:0014823|response to activity;GO:0019395|fatty acid oxidation;GO:0030336|negative regulation of cell migration;GO:0030853|negative regulation of granulocyte differentiation;GO:0031667|response to nutrient levels;GO:0031953|negative regulation of protein autophosphorylation;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032757|positive regulation of interleukin-8 production;GO:0032869|cellular response to insulin stimulus;GO:0033034|positive regulation of myeloid cell apoptotic process;GO:0034115|negative regulation of heterotypic cell-cell adhesion;GO:0034383|low-density lipoprotein particle clearance;GO:0034612|response to tumor necrosis factor;GO:0042593|glucose homeostasis;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043124|negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043407|negative regulation of MAP kinase activity;GO:0045471|response to ethanol;GO:0045599|negative regulation of fat cell differentiation;GO:0045650|negative regulation of macrophage differentiation;GO:0045721|negative regulation of gluconeogenesis;GO:0045776|negative regulation of blood pressure;GO:0045860|positive regulation of protein kinase activity;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045923|positive regulation of fatty acid metabolic process;GO:0046326|positive regulation of glucose import;GO:0046888|negative regulation of hormone secretion;GO:0050728|negative regulation of inflammatory response;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050765|negative regulation of phagocytosis;GO:0050805|negative regulation of synaptic transmission;GO:0050873|brown fat cell differentiation;GO:0051384|response to glucocorticoid;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0070543|response to linoleic acid;GO:0070994|detection of oxidative stress;GO:0071320|cellular response to cAMP;GO:0071466|cellular response to xenobiotic stimulus;GO:0071639|positive regulation of monocyte chemotactic protein-1 production;GO:0071872|cellular response to epinephrine stimulus;GO:0072659|protein localization to plasma membrane;GO:0090317|negative regulation of intracellular protein transport;GO:0110113|positive regulation of lipid transporter activity;GO:0120162|positive regulation of cold-induced thermogenesis;GO:0120163|negative regulation of cold-induced thermogenesis;GO:1900121|negative regulation of receptor binding;GO:1904706|negative regulation of vascular smooth muscle cell proliferation;GO:1904753|negative regulation of vascular associated smooth muscle cell migration;GO:1905598|negative regulation of low-density lipoprotein receptor activity;GO:2000279|negative regulation of DNA biosynthetic process;GO:2000467|positive regulation of glycogen (starch) synthase activity;GO:2000478|positive regulation of metanephric glomerular visceral epithelial cell development;GO:2000481|positive regulation of cAMP-dependent protein kinase activity;GO:2000534|positive regulation of renal albumin absorption;GO:2000584|negative regulation of platelet-derived growth factor receptor-alpha signaling pathway;GO:2000590|negative regulation of metanephric mesenchymal cell migration;","GO:0005581|collagen trimer;GO:0005615|extracellular space;GO:0005783|endoplasmic reticulum;GO:0009986|cell surface;GO:0032991|protein-containing complex;GO:0048471|perinuclear region of cytoplasm;GO:0071944|cell periphery;","GO:0005102|signaling receptor binding;GO:0005179|hormone activity;GO:0033691|sialic acid binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;","K07296","ADIPOQ, ACDC; adiponectin"]
["ENSRNOG00000015505",82,5.275095931,900,58.10567369,0.090784524,-3.461409806,{"v":4.5983e-172,"d":"4.60E-172"},{"v":4.673e-171,"d":"4.67E-171"},"down","yes","Mfap5","protein_coding","chr4:155727925-155750458:+","gi|157821273|ref|NP_001102114.1|",723,{"v":3e-91,"d":"3.00E-91"},"microfibrillar-associated protein 5 precursor [Rattus norvegicus]","gi|157821272|ref|NM_001108644.1|",642,0,"Rattus norvegicus microfibrillar associated protein 5 (Mfap5), mRNA","Q9QZJ6",268,{"v":7e-87,"d":"7.00E-87"},"Microfibrillar-associated protein 5",".",".",".",".","pfam05507","MAGP","Microfibril-associated glycoprotein (MAGP). This family consists of several mammalian microfibril-associated glycoprotein (MAGP) 1 and 2 proteins. MAGP1 and 2 are components of elastic fibres. MAGP-1 has been proposed to bind a C-terminal region of tropoelastin, the soluble precursor of elastin. MAGP-2 was found to interact with fibrillin-1 and -2, as well as fibulin-1, another component of elastic fibres this suggests that MAGP-2 may be important in the assembly of microfibrils.","GO:0048048|embryonic eye morphogenesis;GO:0060216|definitive hemopoiesis;GO:0097435|supramolecular fiber organization;","GO:0001527|microfibril;GO:0005576|extracellular region;GO:0031012|extracellular matrix;",".","K25410","MFAP5; microfibrillar-associated protein 5"]
["ENSRNOG00000021919",741,47.66885469,2225,143.6501377,0.331839951,-1.591440508,{"v":6.3084E-172,"d":"6.31E-172"},{"v":6.3996e-171,"d":"6.40E-171"},"down","yes","Rhoj","protein_coding","chr6:94035483-94118275:+","gi|148704543|gb|EDL36490.1|",1106,{"v":3e-142,"d":"3.00E-142"},"ras homolog gene family, member J, isoform CRA_b, partial [Mus musculus]","gi|56605717|ref|NM_001008320.1|",1753,0,"Rattus norvegicus ras homolog family member J (Rhoj), mRNA","Q9ER71",410,{"v":1E-136,"d":"1.00E-136"},"Rho-related GTP-binding protein RhoJ","SPAC110.03",236,{"v":2e-71,"d":"2.00E-71"},"COG1100","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0006897|endocytosis;GO:0007266|Rho protein signal transduction;GO:0008360|regulation of cell shape;GO:0010594|regulation of endothelial cell migration;GO:0016477|cell migration;GO:0030031|cell projection assembly;GO:0030036|actin cytoskeleton organization;GO:0032488|Cdc42 protein signal transduction;GO:0061299|retina vasculature morphogenesis in camera-type eye;GO:0090050|positive regulation of cell migration involved in sprouting angiogenesis;GO:1903670|regulation of sprouting angiogenesis;","GO:0005886|plasma membrane;","GO:0003924|GTPase activity;GO:0005525|GTP binding;","K07864","RHOJ, TCL; Ras homolog gene family, member J"]
["ENSRNOG00000013408",63,4.052817606,834,53.84459095,0.075268797,-3.731804269,{"v":8.6366e-169,"d":"8.64E-169"},{"v":8.6386e-168,"d":"8.64E-168"},"down","yes","Npas2","protein_coding","chr9:41463830-41642320:+","gi|210032658|ref|NP_001101684.2|",3666,0,"neuronal PAS domain-containing protein 2 [Rattus norvegicus]","gi|210032657|ref|NM_001108214.2|",4273,0,"Rattus norvegicus neuronal PAS domain protein 2 (Npas2), mRNA","P97460",1357,0,"Neuronal PAS domain-containing protein 2",".",".",".",".","pfam14598","PAS_11","PAS domain. This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).","GO:0006357|regulation of transcription by RNA polymerase II;GO:0007623|circadian rhythm;GO:0009410|response to xenobiotic stimulus;GO:0032922|circadian regulation of gene expression;GO:0042745|circadian sleep/wake cycle;GO:0042752|regulation of circadian rhythm;GO:0045475|locomotor rhythm;GO:0045739|positive regulation of DNA repair;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051775|response to redox state;GO:0060548|negative regulation of cell death;GO:2000987|positive regulation of behavioral fear response;GO:2001020|regulation of response to DNA damage stimulus;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005829|cytosol;GO:1990513|CLOCK-BMAL transcription complex;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0046983|protein dimerization activity;GO:0051879|Hsp90 protein binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09026","NPAS2; neuronal PAS domain-containing protein 2"]
["ENSRNOG00000014739",181,11.64380931,1134,73.21314885,0.159039865,-2.652539657,{"v":1.4872e-168,"d":"1.49E-168"},{"v":1.4797E-167,"d":"1.48E-167"},"down","yes","Wfdc2","protein_coding","chr3:153286131-153292807:+","gi|24745184|emb|CAD56203.1|",397,{"v":3e-44,"d":"3.00E-44"},"epididymal secretory protein 4 [Rattus norvegicus]","gi|24745183|emb|AJ515241.1|",486,0,"Rattus norvegicus mRNA for epididymal secretory protein 4 (re4 gene), splice variant 2","Q8CHN3",147,{"v":2E-41,"d":"2.00E-41"},"WAP four-disulfide core domain protein 2",".",".",".",".","pfam00095","WAP","WAP-type (Whey Acidic Protein) 'four-disulfide core'.","GO:0010951|negative regulation of endopeptidase activity;GO:0019731|antibacterial humoral response;GO:0045087|innate immune response;","GO:0005615|extracellular space;","GO:0004867|serine-type endopeptidase inhibitor activity;GO:0004869|cysteine-type endopeptidase inhibitor activity;GO:0019828|aspartic-type endopeptidase inhibitor activity;","K23636","WFDC2; WAP four-disulfide core domain protein 2"]
["ENSRNOG00000014378",16,1.029287011,702,45.32242548,0.022710325,-5.46050784,{"v":4.1406e-167,"d":"4.14E-167"},{"v":4.0985e-166,"d":"4.10E-166"},"down","yes","Il1r2","protein_coding","chr9:42384433-42424725:+","gi|672064768|ref|XP_008765205.1|",2198,0,"PREDICTED: interleukin-1 receptor type 2 isoform X2 [Rattus norvegicus]","gi|672064767|ref|XM_008766983.1|",1374,0,"PREDICTED: Rattus norvegicus interleukin 1 receptor, type II (Il1r2), transcript variant X1, mRNA","P43303",813,0,"Interleukin-1 receptor type 2",".",".",".",".","pfam13927","Ig_3","Immunoglobulin domain. This family contains immunoglobulin-like domains.","GO:0010955|negative regulation of protein processing;GO:0019221|cytokine-mediated signaling pathway;GO:0032690|negative regulation of interleukin-1 alpha production;GO:1900016|negative regulation of cytokine production involved in inflammatory response;GO:2000660|negative regulation of interleukin-1-mediated signaling pathway;","GO:0005576|extracellular region;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004908|interleukin-1 receptor activity;GO:0004910|interleukin-1, type II, blocking receptor activity;GO:0019966|interleukin-1 binding;","K04387","IL1R2, CD121b; interleukin 1 receptor type II"]
["ENSRNOG00000016826",26,1.672591393,722,46.61366267,0.035881999,-4.800595928,{"v":5.6149E-167,"d":"5.61E-167"},{"v":5.5482E-166,"d":"5.55E-166"},"down","yes","Pla2g2d","protein_coding","chr5:151018870-151022525:+","gi|149024390|gb|EDL80887.1|",994,{"v":4e-128,"d":"4.00E-128"},"phospholipase A2, group IID [Rattus norvegicus]","gi|61740622|ref|NM_001013428.1|",1830,0,"Rattus norvegicus phospholipase A2, group IID (Pla2g2d), mRNA","Q9WVF6",261,{"v":6e-82,"d":"6.00E-82"},"Group IID secretory phospholipase A2",".",".",".",".","pfam00068","Phospholip_A2_1","Phospholipase A2. Phospholipase A2 releases fatty acids from the second carbon group of glycerol. Perhaps the best known members are secreted snake venoms, but also found in secreted pancreatic and membrane-associated forms. Structure is all-alpha, with two core disulfide-linked helices and a calcium-binding loop. This alignment represents the major family of PLA2s. A second minor family, defined by the honeybee venom PLA2 PDB:1POC and related sequences from Gila monsters (Heloderma), is not recognized. This minor family conserves the core helix pair but is substantially different elsewhere. The PROSITE pattern PA2_HIS, specific to the first core helix, recognizes both families.","GO:0002361|CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0002864|regulation of acute inflammatory response to antigenic stimulus;GO:0006644|phospholipid metabolic process;GO:0016042|lipid catabolic process;GO:0042130|negative regulation of T cell proliferation;GO:0046337|phosphatidylethanolamine metabolic process;GO:0046470|phosphatidylcholine metabolic process;GO:0046471|phosphatidylglycerol metabolic process;GO:0050482|arachidonic acid secretion;GO:0050868|negative regulation of T cell activation;","GO:0005576|extracellular region;","GO:0004623|phospholipase A2 activity;GO:0005509|calcium ion binding;GO:0005543|phospholipid binding;GO:0008201|heparin binding;GO:0043395|heparan sulfate proteoglycan binding;GO:0047498|calcium-dependent phospholipase A2 activity;","K01047","PLA2G, SPLA2; secretory phospholipase A2 [EC:3.1.1.4]"]
["ENSRNOG00000016812",20,1.286608764,708,45.70979664,0.028147331,-5.150858075,{"v":5.893e-167,"d":"5.89E-167"},{"v":5.8129e-166,"d":"5.81E-166"},"down","yes","Adamts16","protein_coding","chr1:32430436-32560494:+","gi|392334541|ref|XP_003753205.1|",6119,0,"PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 16 isoform X1 [Rattus norvegicus]","gi|672012606|ref|XM_003753157.3|",4976,0,"PREDICTED: Rattus norvegicus ADAM metallopeptidase with thrombospondin type 1 motif, 16 (Adamts16), transcript variant X1, mRNA","Q69Z28",2187,0,"A disintegrin and metalloproteinase with thrombospondin motifs 16",".",".",".",".","pfam05986","ADAM_spacer1","ADAM-TS Spacer 1. This family represents the Spacer-1 region from the ADAM-TS family of metalloproteinases.","GO:0001658|branching involved in ureteric bud morphogenesis;GO:0003073|regulation of systemic arterial blood pressure;GO:0006508|proteolysis;GO:0030198|extracellular matrix organization;GO:0048232|male gamete generation;GO:1902017|regulation of cilium assembly;","GO:0005576|extracellular region;GO:0031012|extracellular matrix;","GO:0004222|metalloendopeptidase activity;GO:0046872|metal ion binding;","K08630","ADAMTS16; a disintegrin and metalloproteinase with thrombospondin motifs 16 [EC:3.4.24.-]"]
["ENSRNOG00000019183",91,5.854069875,900,58.10567369,0.100748679,-3.31116717,{"v":6.1034e-166,"d":"6.10E-166"},{"v":5.9998e-165,"d":"6.00E-165"},"down","yes","Alox15","protein_coding","chr10:55060412-55068874:-","gi|564372995|ref|XP_006246886.1|",3542,0,"PREDICTED: arachidonate 15-lipoxygenase isoform X2 [Rattus norvegicus]","gi|672068098|ref|XM_006246824.2|",2364,0,"PREDICTED: Rattus norvegicus arachidonate 15-lipoxygenase (Alox15), transcript variant X2, mRNA","Q02759",1212,0,"Arachidonate 15-lipoxygenase",".",".",".",".","pfam00305","Lipoxygenase","Lipoxygenase.","GO:0001503|ossification;GO:0002820|negative regulation of adaptive immune response;GO:0006629|lipid metabolic process;GO:0006646|phosphatidylethanolamine biosynthetic process;GO:0010811|positive regulation of cell-substrate adhesion;GO:0019369|arachidonic acid metabolic process;GO:0019372|lipoxygenase pathway;GO:0019395|fatty acid oxidation;GO:0030282|bone mineralization;GO:0030838|positive regulation of actin filament polymerization;GO:0034116|positive regulation of heterotypic cell-cell adhesion;GO:0034440|lipid oxidation;GO:0034976|response to endoplasmic reticulum stress;GO:0035358|regulation of peroxisome proliferator activated receptor signaling pathway;GO:0035963|cellular response to interleukin-13;GO:0042060|wound healing;GO:0042391|regulation of membrane potential;GO:0043277|apoptotic cell clearance;GO:0043651|linoleic acid metabolic process;GO:0045794|negative regulation of cell volume;GO:0046456|icosanoid biosynthetic process;GO:0050727|regulation of inflammatory response;GO:0051122|hepoxilin biosynthetic process;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071277|cellular response to calcium ion;GO:1901074|regulation of engulfment of apoptotic cell;GO:2001303|lipoxin A4 biosynthetic process;","GO:0005737|cytoplasm;GO:0005811|lipid droplet;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0042383|sarcolemma;","GO:0004052|arachidonate 12-lipoxygenase activity;GO:0005506|iron ion binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0016165|linoleate 13S-lipoxygenase activity;GO:0016702|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;GO:0019870|potassium channel inhibitor activity;GO:0047977|hepoxilin-epoxide hydrolase activity;GO:0050473|arachidonate 15-lipoxygenase activity;GO:0051120|hepoxilin A3 synthase activity;","K00460","ALOX15; arachidonate 15-lipoxygenase [EC:1.13.11.33]"]
["ENSRNOG00000014333",378,24.31690563,1537,99.23157829,0.24505209,-2.028839645,{"v":6.1704e-166,"d":"6.17E-166"},{"v":6.0552e-165,"d":"6.06E-165"},"down","yes","Vcam1","protein_coding","chr2:204038114-204057958:-","gi|6981700|ref|NP_037021.1|",3705,0,"vascular cell adhesion protein 1 precursor [Rattus norvegicus]","gi|58476811|gb|BC089812.1|",2890,0,"Rattus norvegicus vascular cell adhesion molecule 1, mRNA (cDNA clone MGC:108734 IMAGE:7364929), complete cds","P29534",1431,0,"Vascular cell adhesion protein 1",".",".",".",".","pfam05790","C2-set","Immunoglobulin C2-set domain.","GO:0001666|response to hypoxia;GO:0002526|acute inflammatory response;GO:0002544|chronic inflammatory response;GO:0007155|cell adhesion;GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007159|leukocyte cell-cell adhesion;GO:0007160|cell-matrix adhesion;GO:0007507|heart development;GO:0007568|aging;GO:0007584|response to nutrient;GO:0009308|amine metabolic process;GO:0010043|response to zinc ion;GO:0010212|response to ionizing radiation;GO:0022614|membrane to membrane docking;GO:0032496|response to lipopolysaccharide;GO:0034113|heterotypic cell-cell adhesion;GO:0035094|response to nicotine;GO:0035584|calcium-mediated signaling using intracellular calcium source;GO:0035924|cellular response to vascular endothelial growth factor stimulus;GO:0042102|positive regulation of T cell proliferation;GO:0045471|response to ethanol;GO:0050901|leukocyte tethering or rolling;GO:0060326|cell chemotaxis;GO:0060384|innervation;GO:0060669|embryonic placenta morphogenesis;GO:0060710|chorio-allantoic fusion;GO:0060945|cardiac neuron differentiation;GO:0071333|cellular response to glucose stimulus;GO:0071356|cellular response to tumor necrosis factor;GO:0098609|cell-cell adhesion;GO:0140039|cell-cell adhesion in response to extracellular stimulus;GO:1904646|cellular response to amyloid-beta;","GO:0002102|podosome;GO:0005615|extracellular space;GO:0005769|early endosome;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005887|integral component of plasma membrane;GO:0005902|microvillus;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0030175|filopodium;GO:0042383|sarcolemma;GO:0045177|apical part of cell;GO:0071065|alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex;GO:0071944|cell periphery;","GO:0005178|integrin binding;GO:0008131|primary amine oxidase activity;GO:0050839|cell adhesion molecule binding;","K06527","VCAM1, CD106; vascular cell adhesion molecule 1"]
["ENSRNOG00000012049",43,2.766208842,757,48.87332776,0.05659956,-4.143065355,{"v":8.2351e-164,"d":"8.24E-164"},{"v":8.0125e-163,"d":"8.01E-163"},"down","yes","Sox7","protein_coding","chr15:38180503-38187264:+","gi|157823179|ref|NP_001099515.1|",1870,0,"transcription factor SOX-7 [Rattus norvegicus]","gi|157823178|ref|NM_001106045.1|",3282,0,"Rattus norvegicus SRY box 7 (Sox7), mRNA","P40646",708,0,"Transcription factor SOX-7",".",".",".",".","pfam12067","Sox_C_TAD","Sox C-terminal transactivation domain. This domain is found at the C-terminus of the Sox family of transcription factors. It is found associated with pfam00505. It binds to the Armadillo repeats (pfam00514) in Catenin beta-1 (CTNNB1), which is involved in transcriptional regulation. It functions as a transactivating domain (TAD).","GO:0001706|endoderm formation;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008150|biological_process;GO:0008285|negative regulation of cell proliferation;GO:0009653|anatomical structure morphogenesis;GO:0030154|cell differentiation;GO:0043280|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0060828|regulation of canonical Wnt signaling pathway;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003700|DNA-binding transcription factor activity;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09270","SOX7S; transcription factor SOX7/8/10/18 (SOX group E/F)"]
["ENSRNOG00000016890",80,5.146435055,860,55.5231993,0.092689815,-3.431445374,{"v":2.253e-163,"d":"2.25E-163"},{"v":2.1846E-162,"d":"2.18E-162"},"down","yes","Tppp3","protein_coding","chr19:33345898-33349577:-","gi|537191633|gb|ERE77168.1|",908,{"v":5e-120,"d":"5.00E-120"},"tubulin polymerization-promoting protein family member 3-like protein [Cricetulus griseus]","gi|298913491|emb|FQ214516.1|",988,0,"Rattus norvegicus TL0AAA41YD15 mRNA sequence","Q5PPN5",353,{"v":2E-121,"d":"2.00E-121"},"Tubulin polymerization-promoting protein family member 3",".",".",".",".","pfam05517","p25-alpha","p25-alpha. This family encodes a 25 kDa protein that is phosphorylated by a Ser/Thr-Pro kinase. It has been described as a brain specific protein, but it is found in Tetrahymena thermophila.","GO:0001578|microtubule bundle formation;GO:0007566|embryo implantation;GO:0032273|positive regulation of protein polymerization;GO:0046697|decidualization;GO:0046785|microtubule polymerization;","GO:0005874|microtubule;GO:0048471|perinuclear region of cytoplasm;GO:0097427|microtubule bundle;","GO:0015631|tubulin binding;",".","."]
["ENSRNOG00000012640",1888,121.4558673,3934,253.9863559,0.478198393,-1.064318812,{"v":2.4918e-163,"d":"2.49E-163"},{"v":2.4121e-162,"d":"2.41E-162"},"down","yes","Dpp7","protein_coding","chr3:8165091-8169355:-","gi|14010871|ref|NP_114179.1|",2514,0,"dipeptidyl peptidase 2 precursor [Rattus norvegicus]","gi|14010870|ref|NM_031973.1|",1702,0,"Rattus norvegicus dipeptidylpeptidase 7 (Dpp7), mRNA","Q9EPB1",970,0,"Dipeptidyl peptidase 2",".",".",".",".","pfam05577","Peptidase_S28","Serine carboxypeptidase S28. These serine proteases include several eukaryotic enzymes such as lysosomal Pro-X carboxypeptidase, dipeptidyl-peptidase II, and thymus-specific serine peptidase.","GO:0006508|proteolysis;GO:1905146|lysosomal protein catabolic process;","GO:0005576|extracellular region;GO:0005764|lysosome;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0031410|cytoplasmic vesicle;GO:0031982|vesicle;GO:0043231|intracellular membrane-bounded organelle;","GO:0004177|aminopeptidase activity;GO:0008236|serine-type peptidase activity;GO:0008239|dipeptidyl-peptidase activity;","K01276","DPP7; dipeptidyl-peptidase II [EC:3.4.14.2]"]
["ENSRNOG00000007574",28,1.801252269,710,45.83892036,0.039295259,-4.669500912,{"v":1.2445e-162,"d":"1.24E-162"},{"v":1.2027E-161,"d":"1.20E-161"},"down","yes","Padi2","protein_coding","chr5:153209053-153251632:+","gi|149024452|gb|EDL80949.1|",3471,0,"peptidyl arginine deiminase, type II, isoform CRA_a [Rattus norvegicus]","gi|8393934|ref|NM_017226.1|",4370,0,"Rattus norvegicus peptidyl arginine deiminase, type II (Padi2), mRNA","P20717",1341,0,"Protein-arginine deiminase type-2",".",".",".",".","pfam03068","PAD","Protein-arginine deiminase (PAD). Members of this family are found in mammals. In the presence of calcium ions, PAD enzymes EC:3.5.3.15 catalyse the post-translational modification reaction responsible for the formation of citrulline residues: Protein L-arginine + H2O <=> Protein L-citrulline + NH3. Several types are recognized (and included in the family) on the basis of molecular mass, substrate specificity, and tissue localisation. The expression of type I PAD is known to be under the control of oestrogen.","GO:0010848|regulation of chromatin disassembly;GO:0018101|protein citrullination;GO:0021762|substantia nigra development;GO:0030520|intracellular estrogen receptor signaling pathway;GO:0036413|histone H3-R26 citrullination;GO:0036414|histone citrullination;GO:0048096|chromatin-mediated maintenance of transcription;GO:0070100|negative regulation of chemokine-mediated signaling pathway;GO:1901624|negative regulation of lymphocyte chemotaxis;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0035327|transcriptionally active chromatin;","GO:0004668|protein-arginine deiminase activity;GO:0005509|calcium ion binding;GO:0030331|estrogen receptor binding;GO:0042803|protein homodimerization activity;","K01481","E3.5.3.15; protein-arginine deiminase [EC:3.5.3.15]"]
["ENSRNOG00000062678",31,1.994243584,718,46.35541523,0.043020725,-4.538824343,{"v":1.3773e-162,"d":"1.38E-162"},{"v":1.3287e-161,"d":"1.33E-161"},"down","yes","H19","protein_coding","chr1:197730698-197733134:-","gi|111797|pir||S15484",448,{"v":7e-59,"d":"7.00E-59"},"hypothetical protein - rat","gi|224922740|ref|NR_027324.1|",2031,0,"Rattus norvegicus H19, imprinted maternally expressed transcript (non-protein coding) (H19), long non-coding RNA",".",".",".",".",".",".",".",".","pfam15252","DUF4589","Domain of unknown function (DUF4589). This protein family is a domain of unknown function. The precise function of the protein domain remains to be elucidated. This family of proteins is found in eukaryotes and are typically between 215 and 293 amino acids in length. The protein contains two conserved sequence motifs: SSS and KST.",".",".",".",".","."]
["ENSRNOG00000024705",142,9.134922222,1013,65.40116383,0.139675224,-2.839851959,{"v":8.0766e-162,"d":"8.08E-162"},{"v":7.7526e-161,"d":"7.75E-161"},"down","yes","Rarres2","protein_coding","chr4:77522535-77525556:-","gi|61740621|ref|NP_001013445.1|",503,{"v":8e-60,"d":"8.00E-60"},"retinoic acid receptor responder protein 2 precursor [Rattus norvegicus]","gi|169235008|gb|AC135090.3|",560,0,"Rattus norvegicus BAC CH230-446D1 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q8HDG8",172,{"v":2E-51,"d":"2.00E-51"},"Retinoic acid receptor responder protein 2",".",".",".",".","pfam13434","K_oxygenase","L-lysine 6-monooxygenase (NADPH-requiring). This is family of Rossmann fold oxidoreductases that catalyses the NADPH-dependent hydroxylation of lysine at the N6 position, EC:1.14.13.59.","GO:0001523|retinoid metabolic process;GO:0001934|positive regulation of protein phosphorylation;GO:0003084|positive regulation of systemic arterial blood pressure;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0008286|insulin receptor signaling pathway;GO:0010759|positive regulation of macrophage chemotaxis;GO:0014823|response to activity;GO:0019732|antifungal humoral response;GO:0031667|response to nutrient levels;GO:0032869|cellular response to insulin stimulus;GO:0045087|innate immune response;GO:0045600|positive regulation of fat cell differentiation;GO:0046626|regulation of insulin receptor signaling pathway;GO:0048566|embryonic digestive tract development;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:0050873|brown fat cell differentiation;GO:0050921|positive regulation of chemotaxis;GO:0050994|regulation of lipid catabolic process;GO:0061760|antifungal innate immune response;GO:0061771|response to caloric restriction;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0031012|extracellular matrix;GO:0062023|collagen-containing extracellular matrix;","GO:0005102|signaling receptor binding;","K10044","RARRES2; retinoic acid receptor responder protein 2"]
["ENSRNOG00000018570",5,0.321652191,709,45.7743585,0.007026908,-7.152894342,{"v":3.6294e-161,"d":"3.63E-161"},{"v":3.4606e-160,"d":"3.46E-160"},"down","yes","C1qtnf3","protein_coding","chr2:59917188-59939433:+","gi|197313725|ref|NP_001127908.1|",1407,0,"complement C1q tumor necrosis factor-related protein 3 precursor [Rattus norvegicus]","gi|197313724|ref|NM_001134436.1|",1920,0,"Rattus norvegicus C1q and tumor necrosis factor related protein 3 (C1qtnf3), mRNA","Q9ES30",365,{"v":1e-120,"d":"1.00E-120"},"Complement C1q tumor necrosis factor-related protein 3",".",".",".",".","pfam00386","C1q","C1q domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.","GO:0001819|positive regulation of cytokine production;GO:0010629|negative regulation of gene expression;GO:0032715|negative regulation of interleukin-6 production;GO:0035356|cellular triglyceride homeostasis;GO:0042593|glucose homeostasis;GO:0045444|fat cell differentiation;GO:0045721|negative regulation of gluconeogenesis;GO:0050728|negative regulation of inflammatory response;GO:0051897|positive regulation of protein kinase B signaling;GO:0070165|positive regulation of adiponectin secretion;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071638|negative regulation of monocyte chemotactic protein-1 production;GO:1901223|negative regulation of NIK/NF-kappaB signaling;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0032991|protein-containing complex;","GO:0042802|identical protein binding;","K24236","C1QTNF3; complement C1q and tumor necrosis factor-related protein 3"]
["ENSRNOG00000068084",478,30.74994945,1702,109.8842851,0.279839373,-1.837329133,{"v":4.2263e-161,"d":"4.23E-161"},{"v":4.0228e-160,"d":"4.02E-160"},"down","yes","ENSRNOG00000068084","lncRNA","chr5:149533651-149535150:+","gi|74183341|dbj|BAE22582.1|",203,{"v":5e-16,"d":"5.00E-16"},"unnamed protein product [Mus musculus]","gi|342672048|ref|NM_009523.2|",778,0,"Mus musculus wingless-type MMTV integration site family, member 4 (Wnt4), mRNA",".",".",".",".",".",".",".",".","pfam11065","DUF2866","Protein of unknown function (DUF2866). This bacterial family of proteins have no known function.",".",".",".",".","."]
["ENSRNOG00000028814",115,7.398000391,943,60.88183365,0.121514086,-3.040804529,{"v":4.2331e-161,"d":"4.23E-161"},{"v":4.0228e-160,"d":"4.02E-160"},"down","yes","Oasl2","protein_coding","chr12:41709435-41722547:-","gi|672073310|ref|XP_008767549.1|",2522,0,"PREDICTED: 2'-5'-oligoadenylate synthase-like protein 2 isoform X1 [Rattus norvegicus]","gi|672073309|ref|XM_008769327.1|",2214,0,"PREDICTED: Rattus norvegicus 2'-5' oligoadenylate synthetase-like 2 (Oasl2), transcript variant X1, mRNA","Q5MYT9",968,0,"2'-5'-oligoadenylate synthase-like protein 2",".",".",".",".","pfam10421","OAS1_C","2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus. This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between 320 and 344 at the extreme C-terminal end. Oligoadenylate synthetases are antiviral enzymes that counteract vial attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesize 2'.5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication. This domain is often associated with NTP_transf_2 pfam01909.","GO:0009615|response to virus;GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0051607|defense response to virus;GO:0060700|regulation of ribonuclease activity;","GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0016020|membrane;","GO:0001730|2'-5'-oligoadenylate synthetase activity;GO:0003725|double-stranded RNA binding;GO:0005524|ATP binding;GO:0046872|metal ion binding;","K14608","OASL; 2'-5'-oligoadenylate synthase-like protein"]
["ENSRNOG00000016653",264,16.98323568,1283,82.83286594,0.205030159,-2.286091955,{"v":6.3015e-161,"d":"6.30E-161"},{"v":5.9784e-160,"d":"5.98E-160"},"down","yes","Ngef","protein_coding","chr9:88146956-88244914:-","gi|114152091|sp|Q5BKC9.2|NGEF_RAT",3676,0,"RecName: Full=Ephexin-1; AltName: Full=Eph-interacting exchange protein; AltName: Full=Neuronal guanine nucleotide exchange factor","gi|210031333|ref|NM_001136241.1|",2476,0,"Rattus norvegicus neuronal guanine nucleotide exchange factor (Ngef), mRNA","Q5BKC9",1420,0,"Ephexin-1",".",".",".",".","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0007399|nervous system development;GO:0009987|cellular process;GO:0030154|cell differentiation;GO:0043087|regulation of GTPase activity;GO:0048013|ephrin receptor signaling pathway;GO:0050790|regulation of catalytic activity;GO:0061002|negative regulation of dendritic spine morphogenesis;GO:0090630|activation of GTPase activity;GO:0098883|synapse pruning;","GO:0005737|cytoplasm;GO:0016020|membrane;GO:0030426|growth cone;GO:0098978|glutamatergic synapse;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0046875|ephrin receptor binding;","K07525","NGEF, EPHEXIN, ARHGEF27; neuronal guanine nucleotide exchange factor"]
["ENSRNOG00000068914",1440,92.63583099,3256,210.213415,0.440675163,-1.182212507,{"v":3.8179e-160,"d":"3.82E-160"},{"v":3.6102E-159,"d":"3.61E-159"},"down","yes","Nrep","protein_coding","chr18:25017083-25046591:-","gi|30017419|ref|NP_835197.1|",348,{"v":4e-36,"d":"4.00E-36"},"neuronal regeneration-related protein [Rattus norvegicus]","gi|564393094|ref|XM_006254595.1|",1620,0,"PREDICTED: Rattus norvegicus neuronal regeneration related protein (Nrep), transcript variant X1, mRNA","Q80Z34",138,{"v":1e-37,"d":"1.00E-37"},"Neuronal regeneration-related protein",".",".",".",".","pfam11092","Alveol-reg_P311","Neuronal protein 3.1 (p311). P311 has several PEST-like motifs and is found in neuron and muscle cells. P311 could have some function in myo-fibroblast transformation and prevention of fibrosis. It has also been identified as a potential regulator of alveolar generation.",".",".",".",".","."]
["ENSRNOG00000011541",590,37.95495853,1896,122.4092859,0.310066007,-1.689352724,{"v":1.008E-159,"d":"1.01E-159"},{"v":9.5e-159,"d":"9.50E-159"},"down","yes","Cygb","protein_coding","chr10:101877676-101887442:-","gi|18543351|ref|NP_570100.1|",1019,{"v":2E-131,"d":"2.00E-131"},"cytoglobin [Rattus norvegicus]","gi|56961647|ref|NM_130744.2|",2111,0,"Rattus norvegicus cytoglobin (Cygb), mRNA","Q921A4",397,{"v":7e-133,"d":"7.00E-133"},"Cytoglobin",".",".",".",".","pfam00042","Globin","Globin.","GO:0001666|response to hypoxia;GO:0006979|response to oxidative stress;GO:0010764|negative regulation of fibroblast migration;GO:0015671|oxygen transport;GO:0019395|fatty acid oxidation;GO:0032966|negative regulation of collagen biosynthetic process;GO:0098869|cellular oxidant detoxification;GO:2000490|negative regulation of hepatic stellate cell activation;","GO:0005737|cytoplasm;GO:0043005|neuron projection;GO:0043025|neuronal cell body;","GO:0004096|catalase activity;GO:0004601|peroxidase activity;GO:0005344|oxygen carrier activity;GO:0005506|iron ion binding;GO:0019825|oxygen binding;GO:0020037|heme binding;GO:0047888|fatty acid peroxidase activity;","K21894","CYGB; cytoglobin"]
["ENSRNOG00000010457",409,26.31114922,1562,100.8456248,0.260905213,-1.938402325,{"v":6.3289e-159,"d":"6.33E-159"},{"v":5.9549E-158,"d":"5.95E-158"},"down","yes","Vash1","protein_coding","chr6:106329123-106345726:+","gi|109478538|ref|XP_578575.2|",1722,0,"PREDICTED: vasohibin-1 [Rattus norvegicus]","gi|672020983|ref|XM_001058397.5|",3390,0,"PREDICTED: Rattus norvegicus vasohibin 1 (Vash1), transcript variant X1, mRNA","Q8C1W1",657,0,"Vasohibin-1",".",".",".",".","pfam14822","Vasohibin","Vasohibin. This family of proteins function as angiogenesis inhibitors in animals.","GO:0001525|angiogenesis;GO:0001937|negative regulation of endothelial cell proliferation;GO:0006508|proteolysis;GO:0009611|response to wounding;GO:0010596|negative regulation of endothelial cell migration;GO:0016525|negative regulation of angiogenesis;GO:0043537|negative regulation of blood vessel endothelial cell migration;GO:0045765|regulation of angiogenesis;GO:0060674|placenta blood vessel development;GO:0060716|labyrinthine layer blood vessel development;GO:1901491|negative regulation of lymphangiogenesis;GO:2000772|regulation of cellular senescence;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0045177|apical part of cell;","GO:0003779|actin binding;GO:0004181|metallocarboxypeptidase activity;","K23355","VASH; tubulinyl-Tyr carboxypeptidase [EC:3.4.17.17]"]
["ENSRNOG00000053691",1930,124.1577457,3959,255.6004024,0.485749414,-1.041715839,{"v":9.3163e-159,"d":"9.32E-159"},{"v":8.7513e-158,"d":"8.75E-158"},"down","yes","Lama5","protein_coding","chr3:167270296-167318451:-","gi|300798041|ref|NP_001178538.1|",18755,0,"laminin subunit alpha-5 precursor [Rattus norvegicus]","gi|300798040|ref|NM_001191609.1|",11307,0,"Rattus norvegicus laminin subunit alpha 5 (Lama5), mRNA","Q61001",6720,0,"Laminin subunit alpha-5",".",".",".",".","pfam00055","Laminin_N","Laminin N-terminal (Domain VI).","GO:0001658|branching involved in ureteric bud morphogenesis;GO:0001738|morphogenesis of a polarized epithelium;GO:0001755|neural crest cell migration;GO:0001822|kidney development;GO:0001942|hair follicle development;GO:0007229|integrin-mediated signaling pathway;GO:0007411|axon guidance;GO:0007517|muscle organ development;GO:0009887|animal organ morphogenesis;GO:0009888|tissue development;GO:0016331|morphogenesis of embryonic epithelium;GO:0016477|cell migration;GO:0030155|regulation of cell adhesion;GO:0030324|lung development;GO:0030334|regulation of cell migration;GO:0034446|substrate adhesion-dependent cell spreading;GO:0042127|regulation of cell proliferation;GO:0042475|odontogenesis of dentin-containing tooth;GO:0045995|regulation of embryonic development;GO:0048754|branching morphogenesis of an epithelial tube;GO:0060271|cilium assembly;GO:0060445|branching involved in salivary gland morphogenesis;GO:0072659|protein localization to plasma membrane;GO:0098609|cell-cell adhesion;","GO:0005604|basement membrane;GO:0005610|laminin-5 complex;GO:0005615|extracellular space;GO:0016020|membrane;GO:0031012|extracellular matrix;GO:0031594|neuromuscular junction;GO:0043083|synaptic cleft;GO:0043259|laminin-10 complex;","GO:0005178|integrin binding;GO:0005201|extracellular matrix structural constituent;","K06240","LAMA3_5; laminin, alpha 3/5"]
["ENSRNOG00000027037",40,2.573217527,724,46.74278639,0.055050581,-4.183098412,{"v":1.3697E-157,"d":"1.37E-157"},{"v":1.2824E-156,"d":"1.28E-156"},"down","yes","Alox12","protein_coding","chr10:54958271-54970542:-","gi|550540805|sp|F1LQ70.1|LOX12_RAT",3389,0,"RecName: Full=Arachidonate 12-lipoxygenase, 12S-type; Short=12S-LOX; Short=12S-lipoxygenase; AltName: Full=Lipoxin synthase 12-LO; AltName: Full=Platelet-type lipoxygenase 12","gi|157786627|ref|NM_001105798.1|",2832,0,"Rattus norvegicus arachidonate 12-lipoxygenase (Alox12), mRNA","F1LQ70",1310,0,"Arachidonate 12-lipoxygenase, 12S-type",".",".",".",".","pfam00305","Lipoxygenase","Lipoxygenase.","GO:0006629|lipid metabolic process;GO:0007568|aging;GO:0010628|positive regulation of gene expression;GO:0010656|negative regulation of muscle cell apoptotic process;GO:0010942|positive regulation of cell death;GO:0019369|arachidonic acid metabolic process;GO:0019372|lipoxygenase pathway;GO:0019395|fatty acid oxidation;GO:0033559|unsaturated fatty acid metabolic process;GO:0034440|lipid oxidation;GO:0043065|positive regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0043280|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043536|positive regulation of blood vessel endothelial cell migration;GO:0043651|linoleic acid metabolic process;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0051122|hepoxilin biosynthetic process;GO:0051901|positive regulation of mitochondrial depolarization;GO:0061436|establishment of skin barrier;GO:0071396|cellular response to lipid;GO:0090331|negative regulation of platelet aggregation;GO:1901751|leukotriene A4 metabolic process;GO:1905956|positive regulation of endothelial tube morphogenesis;GO:2001303|lipoxin A4 biosynthetic process;GO:2001306|lipoxin B4 biosynthetic process;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0042383|sarcolemma;","GO:0004052|arachidonate 12-lipoxygenase activity;GO:0005506|iron ion binding;GO:0016165|linoleate 13S-lipoxygenase activity;GO:0016702|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;GO:0016787|hydrolase activity;GO:0050473|arachidonate 15-lipoxygenase activity;","K00458","ALOX12; arachidonate 12-lipoxygenase [EC:1.13.11.31]"]
["ENSRNOG00000016070",61,3.924156729,784,50.61649797,0.077527227,-3.689153126,{"v":1.6391e-157,"d":"1.64E-157"},{"v":1.5322e-156,"d":"1.53E-156"},"down","yes","Trpc3","protein_coding","chr2:119481400-119558855:-","gi|672042162|ref|XP_006232344.2|",4457,0,"PREDICTED: short transient receptor potential channel 3 isoform X1 [Rattus norvegicus]","gi|672042161|ref|XM_006232282.2|",3545,0,"PREDICTED: Rattus norvegicus transient receptor potential cation channel, subfamily C, member 3 (Trpc3), transcript variant X1, mRNA","Q9JMI9",1699,0,"Short transient receptor potential channel 3",".",".",".",".","pfam08344","TRP_2","Transient receptor ion channel II. This domain is found in the transient receptor ion channel (Trp) family of proteins. There is strong evidence that Trp proteins are structural elements of calcium-ion entry channels activated by G protein-coupled receptors. This domain does not tend to appear with the TRP domain (pfam06011) but is often found to the C-terminus of Ankyrin repeats (pfam00023).","GO:0006828|manganese ion transport;GO:0007338|single fertilization;GO:0010524|positive regulation of calcium ion transport into cytosol;GO:0033198|response to ATP;GO:0051480|regulation of cytosolic calcium ion concentration;GO:0051592|response to calcium ion;GO:0070588|calcium ion transmembrane transport;GO:1903244|positive regulation of cardiac muscle hypertrophy in response to stress;","GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;GO:0034703|cation channel complex;","GO:0005227|calcium activated cation channel activity;GO:0005262|calcium channel activity;GO:0015279|store-operated calcium channel activity;GO:0070679|inositol 1,4,5 trisphosphate binding;","K04966","TRPC3; transient receptor potential cation channel subfamily C member 3"]
["ENSRNOG00000015449",23,1.479600078,676,43.64381713,0.033901711,-4.8824981,{"v":2.5946e-157,"d":"2.59E-157"},{"v":2.4174e-156,"d":"2.42E-156"},"down","yes","Tmem171","protein_coding","chr2:30035278-30045049:-","gi|564334945|ref|XP_006231896.1|",1586,0,"PREDICTED: transmembrane protein 171 isoform X3 [Rattus norvegicus]","gi|672041192|ref|XM_006231834.2|",1161,0,"PREDICTED: Rattus norvegicus transmembrane protein 171 (Tmem171), transcript variant X2, mRNA","Q6K0P5",545,0,"Transmembrane protein 171",".",".",".",".","pfam15471","TMEM171","Transmembrane protein family 171. This family of proteins is found in eukaryotes. TMEM171 is also known as parturition-related protein 2. Proteins in this family are typically between 242 and 326 amino acids in length.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000006841",139,8.941930908,984,63.5288699,0.140753817,-2.828754052,{"v":1.2553e-156,"d":"1.26E-156"},{"v":1.1658e-155,"d":"1.17E-155"},"down","yes","Ano4","protein_coding","chr7:23329070-23738434:-","gi|568967784|ref|XP_006513818.1|",5729,0,"PREDICTED: anoctamin-4 isoform X2 [Mus musculus]","gi|755534677|ref|XM_006513755.2|",3859,0,"PREDICTED: Mus musculus anoctamin 4 (Ano4), transcript variant X1, mRNA","Q8C5H1",1915,0,"Anoctamin-4",".",".",".",".","pfam04547","Anoctamin","Calcium-activated chloride channel. The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.","GO:0006821|chloride transport;GO:0055085|transmembrane transport;GO:0061589|calcium activated phosphatidylserine scrambling;GO:0061590|calcium activated phosphatidylcholine scrambling;GO:0061591|calcium activated galactosylceramide scrambling;GO:1902476|chloride transmembrane transport;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0005229|intracellular calcium activated chloride channel activity;GO:0005254|chloride channel activity;GO:0017128|phospholipid scramblase activity;GO:0046983|protein dimerization activity;","K19499","ANO4, TMEM16D; anoctamin-4"]
["ENSRNOG00000000288",546,35.12441925,1797,116.0176618,0.302750622,-1.723798172,{"v":8.465E-156,"d":"8.47E-156"},{"v":7.8357e-155,"d":"7.84E-155"},"down","yes","Scarf2","protein_coding","chr11:83175963-83187348:-","gi|564377745|ref|XP_006248750.1|",3050,0,"PREDICTED: scavenger receptor class F member 2 isoform X1 [Rattus norvegicus]","gi|672071682|ref|XM_006248688.2|",3315,0,"PREDICTED: Rattus norvegicus scavenger receptor class F, member 2 (Scarf2), transcript variant X1, mRNA","P59222",1130,0,"Scavenger receptor class F member 2",".",".",".",".","pfam03302","VSP","Giardia variant-specific surface protein.","GO:0006897|endocytosis;GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;",".","GO:0005044|scavenger receptor activity;","K24319","SCARF2; scavenger receptor class F member 2"]
["ENSRNOG00000017980",93,5.982730751,858,55.39407558,0.10800308,-3.210855646,{"v":3.6345e-154,"d":"3.63E-154"},{"v":3.3319e-153,"d":"3.33E-153"},"down","yes","Itgal","protein_coding","chr1:181918183-181955732:+","gi|564331001|ref|XP_006230331.1|",5895,0,"PREDICTED: integrin alpha-L isoform X1 [Rattus norvegicus]","gi|672038444|ref|XM_006230269.2|",4356,0,"PREDICTED: Rattus norvegicus integrin, alpha L (Itgal), transcript variant X1, mRNA","P24063",1983,0,"Integrin alpha-L",".",".",".",".","pfam08441","Integrin_alpha2","Integrin alpha. This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.","GO:0002291|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007159|leukocyte cell-cell adhesion;GO:0007160|cell-matrix adhesion;GO:0007166|cell surface receptor signaling pathway;GO:0007229|integrin-mediated signaling pathway;GO:0022407|regulation of cell-cell adhesion;GO:0022409|positive regulation of cell-cell adhesion;GO:0035683|memory T cell extravasation;GO:0042102|positive regulation of T cell proliferation;GO:0043113|receptor clustering;GO:0050798|activated T cell proliferation;GO:0050850|positive regulation of calcium-mediated signaling;GO:0098609|cell-cell adhesion;","GO:0001772|immunological synapse;GO:0005911|cell-cell junction;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0034687|integrin alphaL-beta2 complex;","GO:0030369|ICAM-3 receptor activity;GO:0044877|protein-containing complex binding;GO:0046872|metal ion binding;GO:0050839|cell adhesion molecule binding;","K05718","ITGAL, CD11a; integrin alpha L"]
["ENSRNOG00000068008",9,0.578973944,642,41.4487139,0.013968442,-6.161685105,{"v":8.6304e-153,"d":"8.63E-153"},{"v":7.8614e-152,"d":"7.86E-152"},"down","yes","ENSRNOG00000068008","lncRNA","chr6:124365829-124398449:+","gi|564357199|ref|XP_006240598.1|",810,{"v":6e-95,"d":"6.00E-95"},"PREDICTED: putative uncharacterized protein C14orf132 homolog [Rattus norvegicus]","gi|672057098|ref|XM_006240536.2|",2055,0,"PREDICTED: Rattus norvegicus uncharacterized LOC100909954 (LOC100909954), mRNA","Q9NPU4",120,{"v":2e-29,"d":"2.00E-29"},"Uncharacterized protein C14orf132",".",".",".",".","pfam15498","Dendrin","Nephrin and CD2AP-binding protein, Dendrin. Dendrin is a family of eukaryotic proteins found in the podocytes of the kidneys. Dendrin, originally identified in telencephalic dendrites, is a constituent of the slit diaphragm, SD, complex of podocytes, where it directly binds to nephrin and CD2AP. Kidney podocytes and their slit diaphragms (SDs) form the final barrier to urinary protein loss. SD proteins also participate in intracellular signalling pathways. Dendrin appears to prevent programmed cell death (apoptosis) through its binding to nephrin. The SD protein nephrin serves as a component of a signalling complex that directly links podocyte junctional integrity to actin cytoskeletal dynamics. Thus, dendrin is identified as an SD family with proapoptotic signalling properties that accumulates in the podocyte nucleus in response to glomerular injury.",".",".",".",".","."]
["ENSRNOG00000047951",59,3.795495853,755,48.74420404,0.077865583,-3.682870404,{"v":1.413E-151,"d":"1.41E-151"},{"v":1.283E-150,"d":"1.28E-150"},"down","yes","Hoxa5","protein_coding","chr4:81302353-81306234:-","gi|564303752|ref|XP_003753945.2|",1614,0,"PREDICTED: homeobox protein Hox-A5 [Rattus norvegicus]","gi|564303751|ref|XM_003753897.2|",2920,0,"PREDICTED: Rattus norvegicus homeobox protein Hox-A5 (LOC103689922), mRNA","A2D5Y4",405,{"v":7e-132,"d":"7.00E-132"},"Homeobox protein Hox-A5",".",".",".",".","pfam00046","Homeobox","Homeobox domain.",".",".",".",".","."]
["ENSRNOG00000065195",45,2.894869718,713,46.03260593,0.062887374,-3.991085789,{"v":4.4181e-151,"d":"4.42E-151"},{"v":4.0052e-150,"d":"4.01E-150"},"down","yes","ENSRNOG00000065195","protein_coding","chr6:131831454-131854463:-","gi|672057367|ref|XP_008763214.1|",26725,0,"PREDICTED: protein AHNAK2 isoform X2, partial [Rattus norvegicus]","gi|672057366|ref|XM_008764992.1|",9105,0,"PREDICTED: Rattus norvegicus AHNAK nucleoprotein 2 (Ahnak2), transcript variant X2, partial mRNA","Q8IVF2",3713,0,"Protein AHNAK2",".",".",".",".","pfam05109","Herpes_BLLF1","Herpes virus major outer envelope glycoprotein (BLLF1). This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralizing antibodies in vivo.",".",".",".",".","."]
["ENSRNOG00000017416",881,56.67511604,2333,150.6228186,0.37627178,-1.410153002,{"v":5.6899e-151,"d":"5.69E-151"},{"v":5.15e-150,"d":"5.15E-150"},"down","yes","Ppic","protein_coding","chr18:46842409-46855017:-","gi|51948402|ref|NP_001004215.1|",902,{"v":6e-117,"d":"6.00E-117"},"peptidyl-prolyl cis-trans isomerase C precursor [Rattus norvegicus]","gi|51948401|ref|NM_001004215.1|",1313,0,"Rattus norvegicus peptidylprolyl isomerase C (Ppic), mRNA","P30412",342,{"v":2e-114,"d":"2.00E-114"},"Peptidyl-prolyl cis-trans isomerase C",".",".",".",".","pfam00160","Pro_isomerase","Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD. The peptidyl-prolyl cis-trans isomerases, also known as cyclophilins, share this domain of about 109 amino acids. Cyclophilins have been found in all organisms studied so far and catalyse peptidyl-prolyl isomerization during which the peptide bond preceding proline (the peptidyl-prolyl bond) is stabilized in the cis conformation. Mammalian cyclophilin A (CypA) is a major cellular target for the immunosuppressive drug cyclosporin A (CsA). Other roles for cyclophilins may include chaperone and cell signalling function.","GO:0000413|protein peptidyl-prolyl isomerization;GO:0006457|protein folding;","GO:0005737|cytoplasm;GO:0043231|intracellular membrane-bounded organelle;","GO:0003755|peptidyl-prolyl cis-trans isomerase activity;GO:0016018|cyclosporin A binding;","K09563","PPIC, CYPC; peptidyl-prolyl isomerase C (cyclophilin C) [EC:5.2.1.8]"]
["ENSRNOG00000053272",16,1.029287011,635,40.99678088,0.025106532,-5.315793401,{"v":8.0022e-151,"d":"8.00E-151"},{"v":7.2315e-150,"d":"7.23E-150"},"down","yes","Chi3l1","protein_coding","chr13:45641802-45649787:+","gi|832626572|ref|NP_001296749.1|",2116,0,"chitinase-3-like protein 1 isoform 1 precursor [Rattus norvegicus]","gi|832626571|ref|NM_001309820.1|",1678,0,"Rattus norvegicus chitinase 3 like 1 (Chi3l1), transcript variant 1, mRNA","Q9WTV1",789,0,"Chitinase-3-like protein 1","BH0916_1",165,{"v":8e-44,"d":"8.00E-44"},"COG3325","pfam00704","Glyco_hydro_18","Glycosyl hydrolases family 18.","GO:0005975|carbohydrate metabolic process;GO:0006032|chitin catabolic process;GO:0006915|apoptotic process;GO:0006954|inflammatory response;GO:0007250|activation of NF-kappaB-inducing kinase activity;GO:0009612|response to mechanical stimulus;GO:0010800|positive regulation of peptidyl-threonine phosphorylation;GO:0030324|lung development;GO:0032757|positive regulation of interleukin-8 production;GO:0034612|response to tumor necrosis factor;GO:0045766|positive regulation of angiogenesis;GO:0051897|positive regulation of protein kinase B signaling;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070555|response to interleukin-1;GO:0070741|response to interleukin-6;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0048471|perinuclear region of cytoplasm;","GO:0003674|molecular_function;GO:0008061|chitin binding;GO:0030246|carbohydrate binding;","K17523","CHI3L1_2; chitinase-3-like protein 1/2"]
["ENSRNOG00000013324",1431,92.05685704,3174,204.9193425,0.449234591,-1.154459075,{"v":1.9737e-150,"d":"1.97E-150"},{"v":1.7752E-149,"d":"1.78E-149"},"down","yes","Cdh5","protein_coding","chr19:815411-854368:-","gi|157817743|ref|NP_001100877.1|",3804,0,"cadherin-5 [Rattus norvegicus]","gi|157817742|ref|NM_001107407.1|",2542,0,"Rattus norvegicus cadherin 5 (Cdh5), mRNA","P55284",1363,0,"Cadherin-5",".",".",".",".","pfam01049","Cadherin_C","Cadherin cytoplasmic region. Cadherins are vital in cell-cell adhesion during tissue differentiation. Cadherins are linked to the cytoskeleton by catenins. Catenins bind to the cytoplasmic tail of the cadherin. Cadherins cluster to form foci of homophilic binding units. A key determinant to the strength of the binding that it is mediated by cadherins is the juxtamembrane region of the cadherin. This region induces clustering and also binds to the protein p120ctn.","GO:0000902|cell morphogenesis;GO:0001932|regulation of protein phosphorylation;GO:0001944|vasculature development;GO:0001955|blood vessel maturation;GO:0006874|cellular calcium ion homeostasis;GO:0007043|cell-cell junction assembly;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0007275|multicellular organism development;GO:0008285|negative regulation of cell proliferation;GO:0010628|positive regulation of gene expression;GO:0016339|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0030335|positive regulation of cell migration;GO:0030513|positive regulation of BMP signaling pathway;GO:0031115|negative regulation of microtubule polymerization;GO:0031334|positive regulation of protein complex assembly;GO:0034332|adherens junction organization;GO:0035307|positive regulation of protein dephosphorylation;GO:0043114|regulation of vascular permeability;GO:0043534|blood vessel endothelial cell migration;GO:0044331|cell-cell adhesion mediated by cadherin;GO:0045766|positive regulation of angiogenesis;GO:0050728|negative regulation of inflammatory response;GO:0070830|bicellular tight junction assembly;GO:0098609|cell-cell adhesion;GO:0098742|cell-cell adhesion via plasma-membrane adhesion molecules;GO:1902396|protein localization to bicellular tight junction;GO:1903142|positive regulation of establishment of endothelial barrier;GO:1903659|regulation of complement-dependent cytotoxicity;GO:2000114|regulation of establishment of cell polarity;GO:2000352|negative regulation of endothelial cell apoptotic process;","GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0005912|adherens junction;GO:0005923|bicellular tight junction;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0016342|catenin complex;GO:0030054|cell junction;GO:0031965|nuclear membrane;GO:0071944|cell periphery;","GO:0005102|signaling receptor binding;GO:0005509|calcium ion binding;GO:0008013|beta-catenin binding;GO:0019903|protein phosphatase binding;GO:0043184|vascular endothelial growth factor receptor 2 binding;GO:0044325|ion channel binding;GO:0045296|cadherin binding;GO:0070051|fibrinogen binding;GO:0070700|BMP receptor binding;GO:1990782|protein tyrosine kinase binding;","K06533","CDH5, CD144; cadherin 5, type 2, VE-cadherin"]
["ENSRNOG00000006723",131,8.427287402,937,60.4944625,0.139306757,-2.843662855,{"v":4.9438e-150,"d":"4.94E-150"},{"v":4.4325e-149,"d":"4.43E-149"},"down","yes","Itga11","protein_coding","chr8:63146001-63254407:+","gi|672062052|ref|XP_008764500.1|",6362,0,"PREDICTED: integrin alpha-11 isoform X2 [Rattus norvegicus]","gi|672062051|ref|XM_008766278.1|",4913,0,"PREDICTED: Rattus norvegicus integrin, alpha 11 (Itga11), transcript variant X2, mRNA","P61622",2385,0,"Integrin alpha-11",".",".",".",".","pfam08441","Integrin_alpha2","Integrin alpha. This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.","GO:0006929|substrate-dependent cell migration;GO:0007160|cell-matrix adhesion;GO:0007229|integrin-mediated signaling pathway;GO:0008150|biological_process;GO:0033627|cell adhesion mediated by integrin;GO:0038065|collagen-activated signaling pathway;","GO:0005575|cellular_component;GO:0005925|focal adhesion;GO:0034681|integrin alpha11-beta1 complex;","GO:0003674|molecular_function;GO:0005518|collagen binding;GO:0038064|collagen receptor activity;GO:0046872|metal ion binding;GO:0098639|collagen binding involved in cell-matrix adhesion;","K06587","ITGA11; integrin alpha 11"]
["ENSRNOG00000017676",473,30.42829726,1634,105.4940787,0.288436068,-1.793676514,{"v":8.5725e-150,"d":"8.57E-150"},{"v":7.6741e-149,"d":"7.67E-149"},"down","yes","Plvap","protein_coding","chr16:18184975-18197301:-","gi|9910520|ref|NP_064471.1|",1969,0,"plasmalemma vesicle-associated protein [Rattus norvegicus]","gi|47718052|gb|BC070900.1|",1194,0,"Rattus norvegicus plasmalemma vesicle associated protein, mRNA (cDNA clone MGC:91710 IMAGE:7100403), complete cds","Q9WV78",762,0,"Plasmalemma vesicle-associated protein",".",".",".",".","pfam06637","PV-1","PV-1 protein (PLVAP). This family consists of several PV-1 (PLVAP) proteins which seem to be specific to mammals. PV-1 is a novel protein component of the endothelial fenestral and stomatal diaphragms. The function of this family is unknown.","GO:0000165|MAPK cascade;GO:0002693|positive regulation of cellular extravasation;GO:0032502|developmental process;GO:0033209|tumor necrosis factor-mediated signaling pathway;GO:0043114|regulation of vascular permeability;","GO:0005901|caveola;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0048471|perinuclear region of cytoplasm;","GO:0042802|identical protein binding;","K17309","PLVAP; plasmalemma vesicle-associated protein"]
["ENSRNOG00000019697",798,51.33568967,2189,141.3259108,0.363243296,-1.460991922,{"v":2.0472e-149,"d":"2.05E-149"},{"v":1.824e-148,"d":"1.82E-148"},"down","yes","Ankrd28","protein_coding","chr16:6914336-7050249:-","gi|148692871|gb|EDL24818.1|",5547,0,"ankyrin repeat domain 28, isoform CRA_a, partial [Mus musculus]","gi|672029073|ref|XM_001057687.5|",5233,0,"PREDICTED: Rattus norvegicus ankyrin repeat domain 28 (Ankrd28), transcript variant X2, mRNA","Q505D1",2085,0,"Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A","TP0835",199,{"v":6E-51,"d":"6.00E-51"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).",".",".",".","K15502","ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A"]
["ENSRNOG00000014294",235,15.11765297,1168,75.40825208,0.200477435,-2.318488232,{"v":3.7555e-149,"d":"3.76E-149"},{"v":3.3357e-148,"d":"3.34E-148"},"down","yes","Ptpn6","protein_coding","chr4:157526035-157550984:-","gi|149049491|gb|EDM01945.1|",3160,0,"protein tyrosine phosphatase, non-receptor type 6, isoform CRA_b [Rattus norvegicus]","gi|71681100|gb|BC099824.1|",1981,0,"Rattus norvegicus protein tyrosine phosphatase, non-receptor type 6, mRNA (cDNA clone MGC:124580 IMAGE:7932620), complete cds","P29351",1208,0,"Tyrosine-protein phosphatase non-receptor type 6","SPAC26F1.10c",151,{"v":4e-37,"d":"4.00E-37"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0002244|hematopoietic progenitor cell differentiation;GO:0002924|negative regulation of humoral immune response mediated by circulating immunoglobulin;GO:0006470|protein dephosphorylation;GO:0008284|positive regulation of cell proliferation;GO:0009611|response to wounding;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0030154|cell differentiation;GO:0030220|platelet formation;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0033277|abortive mitotic cell cycle;GO:0033630|positive regulation of cell adhesion mediated by integrin;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0035556|intracellular signal transduction;GO:0035855|megakaryocyte development;GO:0042130|negative regulation of T cell proliferation;GO:0042267|natural killer cell mediated cytotoxicity;GO:0043407|negative regulation of MAP kinase activity;GO:0043409|negative regulation of MAPK cascade;GO:0045577|regulation of B cell differentiation;GO:0050732|negative regulation of peptidyl-tyrosine phosphorylation;GO:0050853|B cell receptor signaling pathway;GO:0050860|negative regulation of T cell receptor signaling pathway;GO:0051279|regulation of release of sequestered calcium ion into cytosol;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:0070527|platelet aggregation;GO:1905867|epididymis development;GO:2000045|regulation of G1/S transition of mitotic cell cycle;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005911|cell-cell junction;GO:0032991|protein-containing complex;GO:0042105|alpha-beta T cell receptor complex;","GO:0001784|phosphotyrosine residue binding;GO:0004725|protein tyrosine phosphatase activity;GO:0005001|transmembrane receptor protein tyrosine phosphatase activity;GO:0005515|protein binding;GO:0017124|SH3 domain binding;GO:0019901|protein kinase binding;GO:0042169|SH2 domain binding;GO:0046703|natural killer cell lectin-like receptor binding;GO:0050839|cell adhesion molecule binding;GO:0140031|phosphorylation-dependent protein binding;","K05697","PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6 [EC:3.1.3.48]"]
["ENSRNOG00000003183",363,23.35194906,1419,91.61327885,0.25489699,-1.972013755,{"v":7.7341e-148,"d":"7.73E-148"},{"v":6.8378e-147,"d":"6.84E-147"},"down","yes","Fmod","protein_coding","chr13:45493517-45504133:+","gi|149058590|gb|EDM09747.1|",1668,0,"fibromodulin [Rattus norvegicus]","gi|18104932|ref|NM_080698.1|",2937,0,"Rattus norvegicus fibromodulin (Fmod), mRNA","P50609",625,0,"Fibromodulin","alr0124_1",87.4,{"v":5e-17,"d":"5.00E-17"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0030199|collagen fibril organization;GO:0042060|wound healing;GO:0042476|odontogenesis;GO:0043588|skin development;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0062023|collagen-containing extracellular matrix;","GO:0003674|molecular_function;","K08121","FMOD; fibromodulin"]
["ENSRNOG00000004290",620,39.88487167,1881,121.440858,0.328430417,-1.606340348,{"v":1.3168e-147,"d":"1.32E-147"},{"v":1.1606e-146,"d":"1.16E-146"},"down","yes","Grb10","protein_coding","chr14:86495054-86602806:-","gi|672076905|ref|XP_008768569.1|",3176,0,"PREDICTED: growth factor receptor-bound protein 10 isoform X1 [Rattus norvegicus]","gi|672076904|ref|XM_008770347.1|",5008,0,"PREDICTED: Rattus norvegicus growth factor receptor bound protein 10 (Grb10), transcript variant X1, mRNA","P0CE43",1150,0,"Growth factor receptor-bound protein 10",".",".",".",".","pfam08947","BPS","BPS (Between PH and SH2). The BPS (Between PH and SH2) domain, comprised of 2 beta strands and a C-terminal helix, is an approximately 45 residue region found in the adaptor proteins Grb7/10/14 that mediates inhibition of the tyrosine kinase domain of the insulin receptor by binding of the N-terminal portion of the BPS domain to the substrate peptide groove of the kinase, acting as a pseudosubstrate inhibitor.","GO:0007165|signal transduction;GO:0008150|biological_process;GO:0008286|insulin receptor signaling pathway;GO:0010467|gene expression;GO:0030178|negative regulation of Wnt signaling pathway;GO:0030949|positive regulation of vascular endothelial growth factor receptor signaling pathway;GO:0032868|response to insulin;GO:0042326|negative regulation of phosphorylation;GO:0042327|positive regulation of phosphorylation;GO:0045719|negative regulation of glycogen biosynthetic process;GO:0046325|negative regulation of glucose import;GO:0046627|negative regulation of insulin receptor signaling pathway;GO:0048009|insulin-like growth factor receptor signaling pathway;GO:0070371|ERK1 and ERK2 cascade;GO:0120162|positive regulation of cold-induced thermogenesis;GO:1904738|vascular associated smooth muscle cell migration;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0032991|protein-containing complex;","GO:0003674|molecular_function;GO:0005158|insulin receptor binding;GO:0030159|receptor signaling complex scaffold activity;GO:0030674|protein binding, bridging;GO:0042802|identical protein binding;","K20064","GRB10; growth factor receptor-bound protein 10"]
["ENSRNOG00000002667",4,0.257321753,658,42.48170365,6.057237E-3,-7.367124393,{"v":1.732E-147,"d":"1.73E-147"},{"v":1.5242E-146,"d":"1.52E-146"},"down","yes","Lamc2","protein_coding","chr13:65284664-65344200:-","gi|281371494|ref|NP_001094110.1|",6224,0,"laminin subunit gamma-2 precursor [Rattus norvegicus]","gi|281371493|ref|NM_001100640.1|",5154,0,"Rattus norvegicus laminin subunit gamma 2 (Lamc2), mRNA","Q61092",2204,0,"Laminin subunit gamma-2",".",".",".",".","pfam00052","Laminin_B","Laminin B (Domain IV).","GO:0008045|motor neuron axon guidance;GO:0008150|biological_process;GO:0008284|positive regulation of cell proliferation;GO:0009887|animal organ morphogenesis;GO:0009888|tissue development;GO:0016358|dendrite development;GO:0030335|positive regulation of cell migration;","GO:0005604|basement membrane;GO:0005607|laminin-2 complex;GO:0005610|laminin-5 complex;GO:0005615|extracellular space;GO:0005938|cell cortex;GO:0016020|membrane;GO:0031012|extracellular matrix;GO:0048471|perinuclear region of cytoplasm;","GO:0003674|molecular_function;GO:0005102|signaling receptor binding;GO:0008201|heparin binding;","K06246","LAMC2; laminin, gamma 2"]
["ENSRNOG00000013917",376,24.18824476,1442,93.09820162,0.259814307,-1.944447217,{"v":1.8014E-147,"d":"1.80E-147"},{"v":1.5828e-146,"d":"1.58E-146"},"down","yes","Igsf10","protein_coding","chr2:143576070-143604773:-","gi|149064694|gb|EDM14845.1|",13314,0,"rCG50104 [Rattus norvegicus]","gi|261245081|ref|NM_198768.2|",8728,0,"Rattus norvegicus immunoglobulin superfamily, member 10 (Igsf10), mRNA","Q6WRH9",5100,0,"Immunoglobulin superfamily member 10","alr0124_1",54.3,4e-06,"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0001503|ossification;GO:0030154|cell differentiation;GO:0042246|tissue regeneration;GO:2001222|regulation of neuron migration;","GO:0005576|extracellular region;",".",".","."]
["ENSRNOG00000005041",974,62.65784679,2457,158.6284892,0.394997438,-1.3400848,{"v":3.6021E-147,"d":"3.60E-147"},{"v":3.1554E-146,"d":"3.16E-146"},"down","yes","Crip2","protein_coding","chr6:132221082-132226065:+","gi|11968068|ref|NP_071946.1|",953,{"v":4e-124,"d":"4.00E-124"},"cysteine-rich protein 2 [Rattus norvegicus]","gi|672057202|ref|XM_008764943.1|",1418,0,"PREDICTED: Rattus norvegicus cysteine-rich protein 2 (Crip2), transcript variant X1, mRNA","P36201",371,{"v":1E-125,"d":"1.00E-125"},"Cysteine-rich protein 2",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.","GO:0008284|positive regulation of cell proliferation;GO:0030097|hemopoiesis;","GO:0005938|cell cortex;","GO:0046872|metal ion binding;","K24413","CRIP2_3, CRP2_3; cysteine-rich protein 2/3"]
["ENSRNOG00000021137",162,10.42153099,996,64.30361222,0.162067583,-2.625332549,{"v":1.1605e-146,"d":"1.16E-146"},{"v":1.0119e-145,"d":"1.01E-145"},"down","yes","Kctd15","protein_coding","chr1:87258658-87273497:-","gi|589944743|ref|XP_006985061.1|",1293,{"v":2E-167,"d":"2.00E-167"},"PREDICTED: BTB/POZ domain-containing protein KCTD15 isoform X1 [Peromyscus maniculatus bairdii]","gi|157820508|ref|NM_001109141.1|",2065,0,"Rattus norvegicus potassium channel tetramerization domain containing 15 (Kctd15), mRNA","Q8K0E1",500,{"v":3e-168,"d":"3.00E-168"},"BTB/POZ domain-containing protein KCTD15",".",".",".",".","pfam02214","BTB_2","BTB/POZ domain. In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.","GO:0051260|protein homooligomerization;",".","GO:0042802|identical protein binding;","K21754","KCTD1_15; BTB/POZ domain-containing protein KCTD1/15"]
["ENSRNOG00000012512",266,17.11189656,1220,78.76546878,0.21725125,-2.202563616,{"v":2.099e-146,"d":"2.10E-146"},{"v":1.8274e-145,"d":"1.83E-145"},"down","yes","Nexn","protein_coding","chr2:241186790-241218342:-","gi|672044473|ref|XP_008759770.1|",2423,0,"PREDICTED: nexilin isoform X4 [Rattus norvegicus]","gi|672044472|ref|XM_008761548.1|",2748,0,"PREDICTED: Rattus norvegicus nexilin (F actin binding protein) (Nexn), transcript variant X3, mRNA","Q9Z2J4",894,0,"Nexilin",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0007155|cell adhesion;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007411|axon guidance;GO:0009617|response to bacterium;GO:0030334|regulation of cell migration;GO:0051493|regulation of cytoskeleton organization;GO:0070593|dendrite self-avoidance;","GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0005912|adherens junction;GO:0005925|focal adhesion;GO:0015629|actin cytoskeleton;GO:0030018|Z disc;GO:0030055|cell-substrate junction;GO:0030424|axon;","GO:0008307|structural constituent of muscle;GO:0051015|actin filament binding;GO:0098632|cell-cell adhesion mediator activity;","K23918","NEXN; nexilin"]
["ENSRNOG00000020845",469,30.17097551,1605,103.6217847,0.291164407,-1.780094089,{"v":1.1782e-145,"d":"1.18E-145"},{"v":1.0181E-144,"d":"1.02E-144"},"down","yes","Tyrobp","protein_coding","chr1:85672994-85676848:+","gi|47058976|ref|NP_997690.1|",594,{"v":7e-76,"d":"7.00E-76"},"TYRO protein tyrosine kinase-binding protein precursor [Rattus norvegicus]","gi|298889183|emb|FQ211365.1|",529,0,"Rattus norvegicus TL0ABA12YD08 mRNA sequence","Q6X9T7",233,{"v":2e-77,"d":"2.00E-77"},"TYRO protein tyrosine kinase-binding protein",".",".",".",".","pfam07213","DAP10","DAP10 membrane protein. This family consists of several mammalian DAP10 membrane proteins. In activated mouse natural killer (NK) cells, the NKG2D receptor associates with two intracellular adaptors, DAP10 and DAP12, which trigger phosphatidyl inositol 3 kinase (PI3K) and Syk family protein tyrosine kinases, respectively. It has been suggested that the DAP10-PI3K pathway is sufficient to initiate NKG2D-mediated killing of target cells.","GO:0002222|stimulatory killer cell immunoglobulin-like receptor signaling pathway;GO:0002223|stimulatory C-type lectin receptor signaling pathway;GO:0002274|myeloid leukocyte activation;GO:0002281|macrophage activation involved in immune response;GO:0002282|microglial cell activation involved in immune response;GO:0002283|neutrophil activation involved in immune response;GO:0007229|integrin-mediated signaling pathway;GO:0010628|positive regulation of gene expression;GO:0030036|actin cytoskeleton organization;GO:0030316|osteoclast differentiation;GO:0030889|negative regulation of B cell proliferation;GO:0030900|forebrain development;GO:0032693|negative regulation of interleukin-10 production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032755|positive regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032816|positive regulation of natural killer cell activation;GO:0032911|negative regulation of transforming growth factor beta1 production;GO:0032930|positive regulation of superoxide anion generation;GO:0034241|positive regulation of macrophage fusion;GO:0043277|apoptotic cell clearance;GO:0048678|response to axon injury;GO:0050821|protein stabilization;GO:0097190|apoptotic signaling pathway;GO:0110090|positive regulation of hippocampal neuron apoptotic process;GO:1900272|negative regulation of long-term synaptic potentiation;GO:1901216|positive regulation of neuron death;GO:1902685|positive regulation of receptor localization to synapse;GO:1904151|positive regulation of microglial cell mediated cytotoxicity;GO:2000010|positive regulation of protein localization to cell surface;GO:2001204|regulation of osteoclast development;GO:2001206|positive regulation of osteoclast development;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;","GO:0005102|signaling receptor binding;GO:0005515|protein binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0046872|metal ion binding;","K07992","TYROBP, DAP12; TYRO protein tyrosine kinase binding protein"]
["ENSRNOG00000000569",302,19.42779233,1289,83.2202371,0.233450336,-2.098812428,{"v":1.3103E-145,"d":"1.31E-145"},{"v":1.1304e-144,"d":"1.13E-144"},"down","yes","Vsir","protein_coding","chr20:28281596-28303878:+","gi|564397877|ref|XP_006256488.1|",1504,0,"PREDICTED: platelet receptor Gi24 isoform X1 [Rattus norvegicus]","gi|672086369|ref|XM_006256426.2|",1895,0,"PREDICTED: Rattus norvegicus hypothetical protein LOC690899 (MGC112715), transcript variant X1, mRNA","Q9D659",483,{"v":7e-166,"d":"7.00E-166"},"V-type immunoglobulin domain-containing suppressor of T-cell activation",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.","GO:0002725|negative regulation of T cell cytokine production;GO:0010628|positive regulation of gene expression;GO:0010950|positive regulation of endopeptidase activity;GO:0030335|positive regulation of cell migration;GO:0030509|BMP signaling pathway;GO:0030513|positive regulation of BMP signaling pathway;GO:0031638|zymogen activation;GO:0032689|negative regulation of interferon-gamma production;GO:0032693|negative regulation of interleukin-10 production;GO:0032700|negative regulation of interleukin-17 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0045591|positive regulation of regulatory T cell differentiation;GO:0048863|stem cell differentiation;GO:0120158|positive regulation of collagen catabolic process;GO:2000562|negative regulation of CD4-positive, alpha-beta T cell proliferation;GO:2000565|negative regulation of CD8-positive, alpha-beta T cell proliferation;GO:2000738|positive regulation of stem cell differentiation;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0019899|enzyme binding;GO:0042802|identical protein binding;GO:0061133|endopeptidase activator activity;","K23268","VSIR, VISTA; V-type immunoglobulin domain-containing suppressor of T-cell activation"]
["ENSRNOG00000012160",142,9.134922222,944,60.94639551,0.149884536,-2.738076549,{"v":2.011E-145,"d":"2.01E-145"},{"v":1.7323e-144,"d":"1.73E-144"},"down","yes","Syk","protein_coding","chr17:12604619-12661410:-","gi|149044986|gb|EDL98072.1|",3332,0,"spleen tyrosine kinase, isoform CRA_a [Rattus norvegicus]","gi|6981619|ref|NM_012758.1|",5188,0,"Rattus norvegicus spleen tyrosine kinase (Syk), mRNA","Q64725",1261,0,"Tyrosine-protein kinase SYK","Rv0015c",91.7,{"v":3e-18,"d":"3.00E-18"},"COG0515","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001525|angiogenesis;GO:0001775|cell activation;GO:0001819|positive regulation of cytokine production;GO:0001820|serotonin secretion;GO:0001945|lymph vessel development;GO:0002092|positive regulation of receptor internalization;GO:0002223|stimulatory C-type lectin receptor signaling pathway;GO:0002250|adaptive immune response;GO:0002281|macrophage activation involved in immune response;GO:0002283|neutrophil activation involved in immune response;GO:0002366|leukocyte activation involved in immune response;GO:0002554|serotonin secretion by platelet;GO:0006468|protein phosphorylation;GO:0006606|protein import into nucleus;GO:0007159|leukocyte cell-cell adhesion;GO:0007166|cell surface receptor signaling pathway;GO:0007167|enzyme linked receptor protein signaling pathway;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007229|integrin-mediated signaling pathway;GO:0010543|regulation of platelet activation;GO:0010803|regulation of tumor necrosis factor-mediated signaling pathway;GO:0018105|peptidyl-serine phosphorylation;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0019370|leukotriene biosynthetic process;GO:0030154|cell differentiation;GO:0030593|neutrophil chemotaxis;GO:0031334|positive regulation of protein complex assembly;GO:0031623|receptor internalization;GO:0032481|positive regulation of type I interferon production;GO:0032725|positive regulation of granulocyte macrophage colony-stimulating factor production;GO:0032733|positive regulation of interleukin-10 production;GO:0032735|positive regulation of interleukin-12 production;GO:0032752|positive regulation of interleukin-3 production;GO:0032753|positive regulation of interleukin-4 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032928|regulation of superoxide anion generation;GO:0032930|positive regulation of superoxide anion generation;GO:0033630|positive regulation of cell adhesion mediated by integrin;GO:0035556|intracellular signal transduction;GO:0038063|collagen-activated tyrosine kinase receptor signaling pathway;GO:0038156|interleukin-3-mediated signaling pathway;GO:0042742|defense response to bacterium;GO:0043280|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043306|positive regulation of mast cell degranulation;GO:0043313|regulation of neutrophil degranulation;GO:0043366|beta selection;GO:0043410|positive regulation of MAPK cascade;GO:0043507|positive regulation of JUN kinase activity;GO:0045087|innate immune response;GO:0045579|positive regulation of B cell differentiation;GO:0045588|positive regulation of gamma-delta T cell differentiation;GO:0045780|positive regulation of bone resorption;GO:0046638|positive regulation of alpha-beta T cell differentiation;GO:0046641|positive regulation of alpha-beta T cell proliferation;GO:0046777|protein autophosphorylation;GO:0048514|blood vessel morphogenesis;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050764|regulation of phagocytosis;GO:0050776|regulation of immune response;GO:0050850|positive regulation of calcium-mediated signaling;GO:0050853|B cell receptor signaling pathway;GO:0051090|regulation of DNA-binding transcription factor activity;GO:0051712|positive regulation of killing of cells of other organism;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:0071226|cellular response to molecule of fungal origin;GO:0071396|cellular response to lipid;GO:0071404|cellular response to low-density lipoprotein particle stimulus;GO:0071639|positive regulation of monocyte chemotactic protein-1 production;GO:0090237|regulation of arachidonic acid secretion;GO:0090330|regulation of platelet aggregation;GO:0120162|positive regulation of cold-induced thermogenesis;GO:1900086|positive regulation of peptidyl-tyrosine autophosphorylation;GO:1990858|cellular response to lectin;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0019815|B cell receptor complex;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0032009|early phagosome;GO:0032991|protein-containing complex;GO:0042101|T cell receptor complex;","GO:0001784|phosphotyrosine residue binding;GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0005102|signaling receptor binding;GO:0005178|integrin binding;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0016170|interleukin-15 receptor binding;GO:0019901|protein kinase binding;GO:0019902|phosphatase binding;GO:0019904|protein domain specific binding;GO:0031625|ubiquitin protein ligase binding;GO:0035325|Toll-like receptor binding;GO:0042169|SH2 domain binding;GO:0043274|phospholipase binding;GO:0097110|scaffold protein binding;","K05855","SYK; spleen tyrosine kinase [EC:2.7.10.2]"]
["ENSRNOG00000051619",125,8.041304773,903,58.29935927,0.137931272,-2.857978512,{"v":2.1787e-145,"d":"2.18E-145"},{"v":1.874e-144,"d":"1.87E-144"},"down","yes","Asb2","protein_coding","chr6:122474756-122510854:-","gi|58865544|ref|NP_001011984.1|",3259,0,"ankyrin repeat and SOCS box protein 2 [Rattus norvegicus]","gi|58865543|ref|NM_001011984.1|",2483,0,"Rattus norvegicus ankyrin repeat and SOCS box-containing 2 (Asb2), mRNA","Q5U2S6",1259,0,"Ankyrin repeat and SOCS box protein 2","all2748",119,{"v":7e-28,"d":"7.00E-28"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0000209|protein polyubiquitination;GO:0001947|heart looping;GO:0006511|ubiquitin-dependent protein catabolic process;GO:0014732|skeletal muscle atrophy;GO:0016567|protein ubiquitination;GO:0031532|actin cytoskeleton reorganization;GO:0035556|intracellular signal transduction;GO:0035914|skeletal muscle cell differentiation;GO:0036336|dendritic cell migration;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045445|myoblast differentiation;GO:0055007|cardiac muscle cell differentiation;GO:0055013|cardiac muscle cell development;GO:0071800|podosome assembly;","GO:0000151|ubiquitin ligase complex;GO:0030018|Z disc;GO:0031466|Cul5-RING ubiquitin ligase complex;","GO:0061630|ubiquitin protein ligase activity;GO:0097602|cullin family protein binding;","K10324","ASB2; ankyrin repeat and SOCS box protein 2"]
["ENSRNOG00000000394",442,28.43405368,1547,99.87719689,0.284690145,-1.812535541,{"v":5.9542e-144,"d":"5.95E-144"},{"v":5.106e-143,"d":"5.11E-143"},"down","yes","Srgn","protein_coding","chr20:30442813-30457406:-","gi|149038682|gb|EDL92971.1|",734,{"v":3e-91,"d":"3.00E-91"},"proteoglycan peptide core protein, isoform CRA_b [Rattus norvegicus]","gi|57527906|ref|NM_020074.2|",1283,0,"Rattus norvegicus serglycin (Srgn), mRNA","P04917",251,{"v":9e-80,"d":"9.00E-80"},"Serglycin",".",".",".",".","pfam04360","Serglycin","Serglycin. Serglycin is the most prevalent proteoglycan produced in haemopoietic cells. Serglycin is a proteinase resistant secretory granule proteoglycan.","GO:0001818|negative regulation of cytokine production;GO:0006915|apoptotic process;GO:0008150|biological_process;GO:0016485|protein processing;GO:0030502|negative regulation of bone mineralization;GO:0031214|biomineral tissue development;GO:0033363|secretory granule organization;GO:0033364|mast cell secretory granule organization;GO:0033371|T cell secretory granule organization;GO:0033373|maintenance of protease location in mast cell secretory granule;GO:0033382|maintenance of granzyme B location in T cell secretory granule;GO:0050804|modulation of chemical synaptic transmission;GO:0099175|regulation of postsynapse organization;","GO:0000139|Golgi membrane;GO:0005615|extracellular space;GO:0005794|Golgi apparatus;GO:0030141|secretory granule;GO:0042588|zymogen granule;GO:0042629|mast cell granule;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098978|glutamatergic synapse;GO:0099091|postsynaptic specialization, intracellular component;","GO:0005518|collagen binding;","K06849","PGSG; proteoglycan peptide core protein"]
["ENSRNOG00000055564",678,43.61603709,1958,126.4121212,0.345030498,-1.535204206,{"v":6.7501e-144,"d":"6.75E-144"},{"v":5.7712E-143,"d":"5.77E-143"},"down","yes","RGD1564664","protein_coding","chr3:79920129-79921523:-","gi|158518474|ref|NP_001103525.1|",615,{"v":2E-73,"d":"2.00E-73"},"uncharacterized protein C11orf96 homolog [Rattus norvegicus]","gi|158518473|ref|NM_001110055.1|",1366,0,"Rattus norvegicus similar to LOC387763 protein (RGD1564664), mRNA",".",".",".",".",".",".",".",".","pfam09483","HpaP","Type III secretion protein (HpaP). This entry represents proteins encoded by genes which are always found in type III secretion operons, although their function in the processes of secretion and virulence is unclear. Hpa stands for Hrp-associated gene, where Hrp stands for hypersensitivity response and virulence. see also PMID:18584024",".",".",".",".","."]
["ENSRNOG00000016117",1482,95.33770939,3200,206.5979509,0.461464932,-1.115707077,{"v":1.1643E-143,"d":"1.16E-143"},{"v":9.925e-143,"d":"9.93E-143"},"down","yes","Myof","protein_coding","chr1:235673666-235822334:-","gi|564333593|ref|XP_006231388.1|",10425,0,"PREDICTED: myoferlin isoform X2 [Rattus norvegicus]","gi|569007059|ref|XM_006526995.1|",5550,0,"PREDICTED: Mus musculus myoferlin (Myof), transcript variant X2, mRNA","Q69ZN7",3954,0,"Myoferlin",".",".",".",".","pfam08150","FerB","FerB (NUC096) domain. This is central domain B in proteins of the Ferlin family.","GO:0001778|plasma membrane repair;GO:0006071|glycerol metabolic process;GO:0007009|plasma membrane organization;GO:0007520|myoblast fusion;GO:0030947|regulation of vascular endothelial growth factor receptor signaling pathway;GO:0033292|T-tubule organization;GO:0034605|cellular response to heat;GO:0055001|muscle cell development;GO:0061025|membrane fusion;","GO:0005886|plasma membrane;GO:0005901|caveola;GO:0016021|integral component of membrane;GO:0030659|cytoplasmic vesicle membrane;GO:0031410|cytoplasmic vesicle;GO:0043231|intracellular membrane-bounded organelle;","GO:0005543|phospholipid binding;GO:0046872|metal ion binding;","K22125","MYOF; myoferlin"]
["ENSRNOG00000001770",57,3.666834977,718,46.35541523,0.079102624,-3.660130639,{"v":1.3149e-143,"d":"1.31E-143"},{"v":1.1192e-142,"d":"1.12E-142"},"down","yes","Ehhadh","protein_coding","chr11:79241938-79275188:+","gi|400260680|pdb|3ZW8|A",3358,0,"Chain A, Crystal Structure Of Rat Peroxisomal Multifunctional Enzyme Type 1 (rpmfe1) In Apo Form","gi|59809131|gb|BC089777.1|",2912,0,"Rattus norvegicus enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase, mRNA (cDNA clone MGC:108601 IMAGE:7321434), complete cds","P07896",1298,0,"Peroxisomal bifunctional enzyme","RSc1759_2",335,{"v":3E-103,"d":"3.00E-103"},"COG1250","pfam02737","3HCDH_N","3-hydroxyacyl-CoA dehydrogenase, NAD binding domain. This family also includes lambda crystallin.","GO:0006635|fatty acid beta-oxidation;","GO:0005777|peroxisome;GO:0005829|cytosol;","GO:0003857|3-hydroxyacyl-CoA dehydrogenase activity;GO:0004165|dodecenoyl-CoA delta-isomerase activity;GO:0004300|enoyl-CoA hydratase activity;GO:0016509|long-chain-3-hydroxyacyl-CoA dehydrogenase activity;GO:0016863|intramolecular oxidoreductase activity, transposing C=C bonds;GO:0019899|enzyme binding;GO:0070403|NAD+ binding;","K07514","EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]"]
["ENSRNOG00000052564",157,10.0998788,969,62.56044201,0.161441935,-2.630912726,{"v":4.571e-143,"d":"4.57E-143"},{"v":3.8849e-142,"d":"3.88E-142"},"down","yes","Gpx3","lncRNA","chr10:39028570-39037035:+","gi|41053837|ref|NP_071970.2|",1044,{"v":6e-135,"d":"6.00E-135"},"glutathione peroxidase 3 precursor [Rattus norvegicus]","gi|298906826|emb|FQ228545.1|",1319,0,"Rattus norvegicus TL0ADA7YC06 mRNA sequence","P23764",406,{"v":2E-136,"d":"2.00E-136"},"Glutathione peroxidase 3","STM1341",105,{"v":1e-24,"d":"1.00E-24"},"COG0386","pfam00255","GSHPx","Glutathione peroxidase.","GO:0002238|response to molecule of fungal origin;GO:0006749|glutathione metabolic process;GO:0006979|response to oxidative stress;GO:0009410|response to xenobiotic stimulus;GO:0010033|response to organic substance;GO:0010269|response to selenium ion;GO:0014070|response to organic cyclic compound;GO:0042744|hydrogen peroxide catabolic process;GO:0051412|response to corticosterone;GO:0098869|cellular oxidant detoxification;","GO:0005615|extracellular space;","GO:0004601|peroxidase activity;GO:0004602|glutathione peroxidase activity;GO:0008430|selenium binding;GO:0042802|identical protein binding;","K00432","gpx, btuE, bsaA; glutathione peroxidase [EC:1.11.1.9]"]
["ENSRNOG00000001431",135,8.684609155,916,59.13866344,0.146851631,-2.76756881,{"v":9.7505e-143,"d":"9.75E-143"},{"v":8.2623e-142,"d":"8.26E-142"},"down","yes","Rasa4","protein_coding","chr12:20552806-20580147:-","gi|293341124|ref|XP_002724855.1|",4054,0,"PREDICTED: ras GTPase-activating protein 4 [Rattus norvegicus]","gi|672026669|ref|XM_002724809.3|",2805,0,"PREDICTED: Rattus norvegicus RAS p21 protein activator 4 (Rasa4), mRNA","Q6PFQ7",1483,0,"Ras GTPase-activating protein 4",".",".",".",".","pfam00616","RasGAP","GTPase-activator protein for Ras-like GTPase. All alpha-helical domain that accelerates the GTPase activity of Ras, thereby \"switching\" it into an \"off\" position.","GO:0035556|intracellular signal transduction;GO:0043087|regulation of GTPase activity;GO:0046580|negative regulation of Ras protein signal transduction;GO:0071277|cellular response to calcium ion;",".","GO:0005096|GTPase activator activity;GO:0005543|phospholipid binding;GO:0046872|metal ion binding;","K17630","RASA4, CAPRI; Ras GTPase-activating protein 4"]
["ENSRNOG00000015904",355,22.83730556,1378,88.96624261,0.256696303,-1.961865578,{"v":1.1528e-142,"d":"1.15E-142"},{"v":9.7538e-142,"d":"9.75E-142"},"down","yes","Wfdc1","protein_coding","chr19:47720423-47739108:+","gi|149038321|gb|EDL92681.1|",855,{"v":6e-112,"d":"6.00E-112"},"WAP four-disulfide core domain 1, isoform CRA_b [Rattus norvegicus]","gi|298883653|emb|FQ220334.1|",980,0,"Rattus norvegicus TL0ADA43YE14 mRNA sequence","O70280",213,{"v":6e-97,"d":"6.00E-97"},"WAP four-disulfide core domain protein 1",".",".",".",".","pfam00095","WAP","WAP-type (Whey Acidic Protein) 'four-disulfide core'.","GO:0001558|regulation of cell growth;GO:0009410|response to xenobiotic stimulus;GO:0010951|negative regulation of endopeptidase activity;GO:0032355|response to estradiol;GO:0050680|negative regulation of epithelial cell proliferation;GO:0050728|negative regulation of inflammatory response;GO:0061045|negative regulation of wound healing;","GO:0005615|extracellular space;","GO:0003674|molecular_function;GO:0004867|serine-type endopeptidase inhibitor activity;","K23635","WFDC1; WAP four-disulfide core domain protein 1"]
["ENSRNOG00000033787",86,5.532417684,791,51.06843099,0.108333418,-3.206449749,{"v":4.0951E-142,"d":"4.10E-142"},{"v":3.4496e-141,"d":"3.45E-141"},"down","yes","Adamtsl5","protein_coding","chr7:9363237-9370285:+","gi|564358129|ref|XP_006240979.1|",2698,0,"PREDICTED: ADAMTS-like protein 5 isoform X3 [Rattus norvegicus]","gi|672057763|ref|XM_006240917.2|",2209,0,"PREDICTED: Rattus norvegicus ADAMTS-like 5 (Adamtsl5), transcript variant X3, mRNA","Q6ZMM2",641,0,"ADAMTS-like protein 5",".",".",".",".","pfam05986","ADAM_spacer1","ADAM-TS Spacer 1. This family represents the Spacer-1 region from the ADAM-TS family of metalloproteinases.",".","GO:0001527|microfibril;GO:0005576|extracellular region;GO:0031012|extracellular matrix;","GO:0008201|heparin binding;GO:0050436|microfibril binding;","K24432","ADAMTSL5; ADAMTS-like protein 5"]
["ENSRNOG00000059741",6,0.385982629,607,39.18904881,0.009849247,-6.665770825,{"v":4.1602e-142,"d":"4.16E-142"},{"v":3.4993e-141,"d":"3.50E-141"},"down","yes","Tmc4","protein_coding","chr1:65539721-65551677:+","gi|149029798|gb|EDL84930.1|",3456,0,"transmembrane channel-like gene family 4 [Rattus norvegicus]","gi|77681957|ref|NM_001034104.1|",2262,0,"Rattus norvegicus transmembrane channel-like 4 (Tmc4), mRNA","Q496Z4",1283,0,"Transmembrane channel-like protein 4",".",".",".",".","pfam07810","TMC","TMC domain. These sequences are similar to a region conserved amongst various protein products of the transmembrane channel-like (TMC) gene family, such as Transmembrane channel-like protein 3 and EVIN2 - this region is termed the TMC domain. Mutations in these genes are implicated in a number of human conditions, such as deafness and epidermodysplasia verruciformis. TMC proteins are thought to have important cellular roles, and may be modifiers of ion channels or transporters.","GO:0034220|ion transmembrane transport;","GO:0005887|integral component of plasma membrane;","GO:0008381|mechanosensitive ion channel activity;","K21988","TMC; transmembrane channel-like protein"]
["ENSRNOG00000002730",504,32.42254085,1648,106.3979447,0.304729015,-1.714401223,{"v":5.7166e-142,"d":"5.72E-142"},{"v":4.8014e-141,"d":"4.80E-141"},"down","yes","Rgs5","protein_coding","chr13:81836304-81885518:+","gi|9507045|ref|NP_062214.1|",702,{"v":2E-87,"d":"2.00E-87"},"regulator of G-protein signaling 5 [Rattus norvegicus]","gi|298898144|emb|FQ234716.1|",946,0,"Rattus norvegicus TL0AEA57YO17 mRNA sequence","P49800",275,{"v":5e-89,"d":"5.00E-89"},"Regulator of G-protein signaling 5",".",".",".",".","pfam00615","RGS","Regulator of G protein signaling domain. RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.","GO:0007165|signal transduction;GO:0009968|negative regulation of signal transduction;GO:1904706|negative regulation of vascular smooth muscle cell proliferation;","GO:0005737|cytoplasm;GO:0016020|membrane;",".","K16449","RGS; regulator of G-protein signaling"]
["ENSRNOG00000005903",63,4.052817606,727,46.93647197,0.086346873,-3.53371225,{"v":1.2342e-141,"d":"1.23E-141"},{"v":1.0336E-140,"d":"1.03E-140"},"down","yes","St14","protein_coding","chr8:29540811-29581517:-","gi|16758444|ref|NP_446087.1|",4509,0,"suppressor of tumorigenicity 14 protein [Rattus norvegicus]","gi|31377480|ref|NM_053635.2|",3150,0,"Rattus norvegicus suppression of tumorigenicity 14 (St14), mRNA","P56677",1661,0,"Suppressor of tumorigenicity 14 protein homolog","VC1200",112,{"v":3e-25,"d":"3.00E-25"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0001843|neural tube closure;GO:0006508|proteolysis;GO:0030216|keratinocyte differentiation;GO:0060672|epithelial cell morphogenesis involved in placental branching;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0019897|extrinsic component of plasma membrane;","GO:0004252|serine-type endopeptidase activity;GO:0008236|serine-type peptidase activity;","K08670","ST14, PRSS14; suppressor of tumorigenicity protein 14 [EC:3.4.21.109]"]
["ENSRNOG00000065676",373,23.99525344,1407,90.83853654,0.264152796,-1.920555412,{"v":1.2623e-141,"d":"1.26E-141"},{"v":1.0556e-140,"d":"1.06E-140"},"down","yes","ENSRNOG00000065676","lncRNA","chr7:89725745-89729676:-","gi|344235204|gb|EGV91307.1|",154,2e-09,"hypothetical protein I79_026048 [Cricetulus griseus]","gi|341926178|ref|NM_026346.3|",756,0,"Mus musculus F-box protein 32 (Fbxo32), mRNA",".",".",".",".",".",".",".",".","pfam00003","7tm_3","7 transmembrane sweet-taste receptor of 3 GCPR. This is a domain of seven transmembrane regions that forms the C-terminus of some subclass 3 G-coupled-protein receptors. It is often associated with a downstream cysteine-rich linker domain, NCD3G pfam07562, which is the human sweet-taste receptor, and the N-terminal domain, ANF_receptor pfam01094. The seven TM regions assemble in such a way as to produce a docking pocket into which such molecules as cyclamate and lactisole have been found to bind and consequently confer the taste of sweetness.",".",".",".",".","."]
["ENSRNOG00000003031",1113,71.5997777,2635,170.1205002,0.420876835,-1.248529989,{"v":1.6866e-141,"d":"1.69E-141"},{"v":1.4063e-140,"d":"1.41E-140"},"down","yes","Atp2b4","protein_coding","chr13:45156146-45255246:-","gi|672073695|ref|XP_008767668.1|",6073,0,"PREDICTED: plasma membrane calcium-transporting ATPase 4 isoform X2 [Rattus norvegicus]","gi|672073696|ref|XM_008769447.1|",7741,0,"PREDICTED: Rattus norvegicus ATPase, Ca++ transporting, plasma membrane 4 (Atp2b4), transcript variant X2, mRNA","Q64542",2341,0,"Plasma membrane calcium-transporting ATPase 4",".",".",".",".","pfam00122","E1-E2_ATPase","E1-E2 ATPase.","GO:0003407|neural retina development;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006816|calcium ion transport;GO:0006874|cellular calcium ion homeostasis;GO:0007283|spermatogenesis;GO:0010629|negative regulation of gene expression;GO:0010751|negative regulation of nitric oxide mediated signal transduction;GO:0014832|urinary bladder smooth muscle contraction;GO:0016525|negative regulation of angiogenesis;GO:0021766|hippocampus development;GO:0030317|flagellated sperm motility;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0043537|negative regulation of blood vessel endothelial cell migration;GO:0045019|negative regulation of nitric oxide biosynthetic process;GO:0051001|negative regulation of nitric-oxide synthase activity;GO:0051480|regulation of cytosolic calcium ion concentration;GO:0051599|response to hydrostatic pressure;GO:0070588|calcium ion transmembrane transport;GO:0070885|negative regulation of calcineurin-NFAT signaling cascade;GO:0071872|cellular response to epinephrine stimulus;GO:0098736|negative regulation of the force of heart contraction;GO:0140199|negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process;GO:1900082|negative regulation of arginine catabolic process;GO:1901660|calcium ion export;GO:1902548|negative regulation of cellular response to vascular endothelial growth factor stimulus;GO:1902806|regulation of cell cycle G1/S phase transition;GO:1903078|positive regulation of protein localization to plasma membrane;GO:1903243|negative regulation of cardiac muscle hypertrophy in response to stress;GO:1903249|negative regulation of citrulline biosynthetic process;GO:1905145|cellular response to acetylcholine;GO:2000481|positive regulation of cAMP-dependent protein kinase activity;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0016323|basolateral plasma membrane;GO:0030018|Z disc;GO:0030315|T-tubule;GO:0032991|protein-containing complex;GO:0036126|sperm flagellum;GO:0042383|sarcolemma;GO:0043005|neuron projection;GO:0043231|intracellular membrane-bounded organelle;GO:0097228|sperm principal piece;GO:0098978|glutamatergic synapse;GO:0099059|integral component of presynaptic active zone membrane;","GO:0005388|calcium-transporting ATPase activity;GO:0005516|calmodulin binding;GO:0005524|ATP binding;GO:0015085|calcium ion transmembrane transporter activity;GO:0017080|sodium channel regulator activity;GO:0019829|cation-transporting ATPase activity;GO:0019901|protein kinase binding;GO:0030165|PDZ domain binding;GO:0030346|protein phosphatase 2B binding;GO:0036487|nitric-oxide synthase inhibitor activity;GO:0046872|metal ion binding;GO:0048306|calcium-dependent protein binding;GO:0050998|nitric-oxide synthase binding;GO:0097110|scaffold protein binding;","K05850","ATP2B; P-type Ca2+ transporter type 2B [EC:7.2.2.10]"]
["ENSRNOG00000062503",43,2.766208842,668,43.12732225,0.064140519,-3.962620157,{"v":4.713e-141,"d":"4.71E-141"},{"v":3.9124e-140,"d":"3.91E-140"},"down","yes","ENSRNOG00000062503","lncRNA","chr15:95024031-95027881:+","gi|344238342|gb|EGV94445.1|",142,3e-07,"hypothetical protein I79_000405 [Cricetulus griseus]","gi|672028896|ref|XM_002725130.4|",3851,0,"PREDICTED: Rattus norvegicus similar to Glypican-6 precursor (LOC691984), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam06930","DUF1282","Protein of unknown function (DUF1282). This family consists of several hypothetical proteins of around 200 residues in length. The function of this family is unknown although a number of family members are thought to be putative membrane proteins.",".",".",".",".","."]
["ENSRNOG00000000257",9,0.578973944,587,37.89781162,0.015277239,-6.032472311,{"v":3.3267E-140,"d":"3.33E-140"},{"v":2.7417e-139,"d":"2.74E-139"},"down","yes","Smpd3","protein_coding","chr19:34162341-34245749:-","gi|564395627|ref|XP_006255605.1|",3302,0,"PREDICTED: sphingomyelin phosphodiesterase 3 isoform X1 [Rattus norvegicus]","gi|16758393|ref|NM_053605.1|",4972,0,"Rattus norvegicus sphingomyelin phosphodiesterase 3, neutral membrane (Smpd3), mRNA","O35049",1273,0,"Sphingomyelin phosphodiesterase 3",".",".",".",".","pfam03372","Exo_endo_phos","Endonuclease/Exonuclease/phosphatase family. This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins EC:4.2.99.18, DNase I proteins EC:3.1.21.1, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56, Sphingomyelinase EC:3.1.4.12 and Nocturnin.","GO:0001501|skeletal system development;GO:0001503|ossification;GO:0001932|regulation of protein phosphorylation;GO:0001958|endochondral ossification;GO:0002063|chondrocyte development;GO:0002244|hematopoietic progenitor cell differentiation;GO:0002685|regulation of leukocyte migration;GO:0003433|chondrocyte development involved in endochondral bone morphogenesis;GO:0006665|sphingolipid metabolic process;GO:0006672|ceramide metabolic process;GO:0006684|sphingomyelin metabolic process;GO:0006685|sphingomyelin catabolic process;GO:0007165|signal transduction;GO:0007568|aging;GO:0014824|artery smooth muscle contraction;GO:0015774|polysaccharide transport;GO:0030072|peptide hormone secretion;GO:0030282|bone mineralization;GO:0030324|lung development;GO:0030509|BMP signaling pathway;GO:0032963|collagen metabolic process;GO:0034614|cellular response to reactive oxygen species;GO:0035264|multicellular organism growth;GO:0043491|protein kinase B signaling;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0045840|positive regulation of mitotic nuclear division;GO:0048008|platelet-derived growth factor receptor signaling pathway;GO:0048286|lung alveolus development;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0051216|cartilage development;GO:0051481|negative regulation of cytosolic calcium ion concentration;GO:0060348|bone development;GO:0060541|respiratory system development;GO:0061035|regulation of cartilage development;GO:0070301|cellular response to hydrogen peroxide;GO:0070314|G1 to G0 transition;GO:0071286|cellular response to magnesium ion;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071461|cellular response to redox state;GO:0071897|DNA biosynthetic process;GO:0085029|extracellular matrix assembly;GO:0090494|dopamine uptake;GO:0090520|sphingolipid mediated signaling pathway;GO:0097187|dentinogenesis;GO:0098868|bone growth;GO:0140014|mitotic nuclear division;GO:0140052|cellular response to oxidised low-density lipoprotein particle stimulus;GO:1900125|regulation of hyaluronan biosynthetic process;GO:1900126|negative regulation of hyaluronan biosynthetic process;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1901653|cellular response to peptide;GO:1903543|positive regulation of exosomal secretion;GO:2000304|positive regulation of ceramide biosynthetic process;","GO:0000137|Golgi cis cisterna;GO:0000139|Golgi membrane;GO:0005576|extracellular region;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0001786|phosphatidylserine binding;GO:0004620|phospholipase activity;GO:0004767|sphingomyelin phosphodiesterase activity;GO:0005515|protein binding;GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0061751|neutral sphingomyelin phosphodiesterase activity;GO:0070300|phosphatidic acid binding;","K12352","SMPD3; sphingomyelin phosphodiesterase 3 [EC:3.1.4.12]"]
["ENSRNOG00000009465",5,0.321652191,607,39.18904881,0.008207706,-6.928805231,{"v":3.4142e-140,"d":"3.41E-140"},{"v":2.8097E-139,"d":"2.81E-139"},"down","yes","Sfrp2","protein_coding","chr2:169089517-169097063:+","gi|635045300|ref|XP_007998238.1|",1569,0,"PREDICTED: secreted frizzled-related protein 2 [Chlorocebus sabaeus]","gi|189181699|ref|NM_001100700.1|",1976,0,"Rattus norvegicus secreted frizzled-related protein 2 (Sfrp2), mRNA","P97299",570,0,"Secreted frizzled-related protein 2",".",".",".",".","pfam01392","Fz","Fz domain. Also known as the CRD (cysteine rich domain), the C6 box in MuSK receptor. This domain of unknown function has been independently identified by several groups. The domain contains 10 conserved cysteines.","GO:0001569|branching involved in blood vessel morphogenesis;GO:0001756|somitogenesis;GO:0001843|neural tube closure;GO:0002063|chondrocyte development;GO:0003151|outflow tract morphogenesis;GO:0003214|cardiac left ventricle morphogenesis;GO:0006915|apoptotic process;GO:0007267|cell-cell signaling;GO:0007584|response to nutrient;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0008584|male gonad development;GO:0009410|response to xenobiotic stimulus;GO:0009952|anterior/posterior pattern specification;GO:0010629|negative regulation of gene expression;GO:0010667|negative regulation of cardiac muscle cell apoptotic process;GO:0010719|negative regulation of epithelial to mesenchymal transition;GO:0010950|positive regulation of endopeptidase activity;GO:0010975|regulation of neuron projection development;GO:0021915|neural tube development;GO:0030111|regulation of Wnt signaling pathway;GO:0030178|negative regulation of Wnt signaling pathway;GO:0030199|collagen fibril organization;GO:0030307|positive regulation of cell growth;GO:0030308|negative regulation of cell growth;GO:0030336|negative regulation of cell migration;GO:0030514|negative regulation of BMP signaling pathway;GO:0031668|cellular response to extracellular stimulus;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0033630|positive regulation of cell adhesion mediated by integrin;GO:0035567|non-canonical Wnt signaling pathway;GO:0036342|post-anal tail morphogenesis;GO:0042127|regulation of cell proliferation;GO:0042662|negative regulation of mesodermal cell fate specification;GO:0042733|embryonic digit morphogenesis;GO:0042981|regulation of apoptotic process;GO:0043065|positive regulation of apoptotic process;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043508|negative regulation of JUN kinase activity;GO:0045600|positive regulation of fat cell differentiation;GO:0045669|positive regulation of osteoblast differentiation;GO:0045766|positive regulation of angiogenesis;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046546|development of primary male sexual characteristics;GO:0048546|digestive tract morphogenesis;GO:0050680|negative regulation of epithelial cell proliferation;GO:0050732|negative regulation of peptidyl-tyrosine phosphorylation;GO:0051216|cartilage development;GO:0060028|convergent extension involved in axis elongation;GO:0060070|canonical Wnt signaling pathway;GO:0060349|bone morphogenesis;GO:0061056|sclerotome development;GO:0061185|negative regulation of dermatome development;GO:0071425|hematopoietic stem cell proliferation;GO:0071481|cellular response to X-ray;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0090175|regulation of establishment of planar polarity;GO:0090179|planar cell polarity pathway involved in neural tube closure;GO:0090244|Wnt signaling pathway involved in somitogenesis;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:1902042|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1902230|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:1904956|regulation of midbrain dopaminergic neuron differentiation;GO:2000035|regulation of stem cell division;GO:2000041|negative regulation of planar cell polarity pathway involved in axis elongation;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0062023|collagen-containing extracellular matrix;","GO:0001968|fibronectin binding;GO:0003674|molecular_function;GO:0005178|integrin binding;GO:0008047|enzyme activator activity;GO:0017147|Wnt-protein binding;GO:0048018|receptor ligand activity;GO:0061133|endopeptidase activator activity;","K02176","SFRP2; secreted frizzled-related protein 2"]
["ENSRNOG00000028650",837,53.84457676,2192,141.5195964,0.380474352,-1.39412889,{"v":1.4419e-139,"d":"1.44E-139"},{"v":1.1798E-138,"d":"1.18E-138"},"down","yes","Inf2","protein_coding","chr6:131649211-131675941:+","gi|672021237|ref|XP_008774561.1|",3563,0,"PREDICTED: inverted formin-2 isoform X2 [Rattus norvegicus]","gi|112496672|gb|DQ834374.1|",2876,0,"Mus musculus INF2 mRNA, complete cds","Q0GNC1",1265,0,"Inverted formin-2",".",".",".",".","pfam02181","FH2","Formin Homology 2 Domain.","GO:0030036|actin cytoskeleton organization;GO:0032535|regulation of cellular component size;GO:0090140|regulation of mitochondrial fission;","GO:0048471|perinuclear region of cytoplasm;","GO:0003779|actin binding;GO:0031267|small GTPase binding;","K23958","INF2; inverted formin-2"]
["ENSRNOG00000008045",54,3.473843662,691,44.61224502,0.077867493,-3.682835018,{"v":6.7466e-139,"d":"6.75E-139"},{"v":5.4967e-138,"d":"5.50E-138"},"down","yes","Slamf9","protein_coding","chr13:84941982-84944748:+","gi|157787012|ref|NP_001099441.1|",1339,0,"SLAM family member 9 precursor [Rattus norvegicus]","gi|157787011|ref|NM_001105971.1|",1111,0,"Rattus norvegicus SLAM family member 9 (Slamf9), mRNA","Q9D780",410,{"v":3e-141,"d":"3.00E-141"},"SLAM family member 9",".",".",".",".","pfam13927","Ig_3","Immunoglobulin domain. This family contains immunoglobulin-like domains.","GO:0002273|plasmacytoid dendritic cell differentiation;GO:0002373|plasmacytoid dendritic cell cytokine production;GO:0002410|plasmacytoid dendritic cell chemotaxis;GO:0042110|T cell activation;GO:0042742|defense response to bacterium;","GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000028713",648,41.68612394,1877,121.1826106,0.343994272,-1.539543551,{"v":1.3643e-138,"d":"1.36E-138"},{"v":1.11e-137,"d":"1.11E-137"},"down","yes","Acvrl1","protein_coding","chr7:132239729-132256591:+","gi|149031998|gb|EDL86910.1|",2633,0,"activin A receptor type II-like 1, isoform CRA_a [Rattus norvegicus]","gi|672059824|ref|XM_006242303.2|",3903,0,"PREDICTED: Rattus norvegicus activin A receptor type II-like 1 (Acvrl1), transcript variant X2, mRNA","P80203",997,0,"Serine/threonine-protein kinase receptor R3",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0001525|angiogenesis;GO:0001666|response to hypoxia;GO:0001701|in utero embryonic development;GO:0001937|negative regulation of endothelial cell proliferation;GO:0001938|positive regulation of endothelial cell proliferation;GO:0001946|lymphangiogenesis;GO:0001974|blood vessel remodeling;GO:0003203|endocardial cushion morphogenesis;GO:0006355|regulation of transcription, DNA-templated;GO:0006468|protein phosphorylation;GO:0007162|negative regulation of cell adhesion;GO:0007165|signal transduction;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0007507|heart development;GO:0008015|blood circulation;GO:0008217|regulation of blood pressure;GO:0008285|negative regulation of cell proliferation;GO:0009953|dorsal/ventral pattern formation;GO:0010596|negative regulation of endothelial cell migration;GO:0010629|negative regulation of gene expression;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0030308|negative regulation of cell growth;GO:0030336|negative regulation of cell migration;GO:0030509|BMP signaling pathway;GO:0030513|positive regulation of BMP signaling pathway;GO:0032924|activin receptor signaling pathway;GO:0035313|wound healing, spreading of epidermal cells;GO:0035912|dorsal aorta morphogenesis;GO:0043537|negative regulation of blood vessel endothelial cell migration;GO:0045602|negative regulation of endothelial cell differentiation;GO:0045603|positive regulation of endothelial cell differentiation;GO:0045766|positive regulation of angiogenesis;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048514|blood vessel morphogenesis;GO:0051895|negative regulation of focal adhesion assembly;GO:0060836|lymphatic endothelial cell differentiation;GO:0060840|artery development;GO:0060841|venous blood vessel development;GO:0061154|endothelial tube morphogenesis;GO:0061298|retina vasculature development in camera-type eye;GO:0071363|cellular response to growth factor stimulus;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0071773|cellular response to BMP stimulus;GO:2000279|negative regulation of DNA biosynthetic process;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0030425|dendrite;GO:0043025|neuronal cell body;GO:0043235|receptor complex;GO:0070724|BMP receptor complex;","GO:0004674|protein serine/threonine kinase activity;GO:0004675|transmembrane receptor protein serine/threonine kinase activity;GO:0005024|transforming growth factor beta-activated receptor activity;GO:0005025|transforming growth factor beta receptor activity, type I;GO:0005524|ATP binding;GO:0016361|activin receptor activity, type I;GO:0019901|protein kinase binding;GO:0046332|SMAD binding;GO:0046872|metal ion binding;GO:0048185|activin binding;GO:0050431|transforming growth factor beta binding;GO:0098821|BMP receptor activity;","K13594","ACVRL1, ALK1; activin receptor-like kinase 1 [EC:2.7.11.30]"]
["ENSRNOG00000024931",93,5.982730751,792,51.13299285,0.117003336,-3.095378428,{"v":7.1595e-138,"d":"7.16E-138"},{"v":5.7836e-137,"d":"5.78E-137"},"down","yes","Ccdc88b","protein_coding","chr1:204036918-204052970:-","gi|109463441|ref|XP_001072042.1|",5985,0,"PREDICTED: coiled-coil domain-containing protein 88B [Rattus norvegicus]","gi|672014616|ref|XM_001072042.4|",4908,0,"PREDICTED: Rattus norvegicus coiled-coil domain containing 88B (Ccdc88b), mRNA","Q4QRL3",2004,0,"Coiled-coil domain-containing protein 88B",".",".",".",".","pfam05622","HOOK","HOOK protein. This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organisms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas the central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head.","GO:0001819|positive regulation of cytokine production;GO:0030705|cytoskeleton-dependent intracellular transport;GO:0031122|cytoplasmic microtubule organization;GO:0042102|positive regulation of T cell proliferation;GO:0042832|defense response to protozoan;GO:0050870|positive regulation of T cell activation;","GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0016020|membrane;","GO:0008017|microtubule binding;GO:0051959|dynein light intermediate chain binding;",".","."]
["ENSRNOG00000001480",154,9.90688748,937,60.4944625,0.163765196,-2.610299316,{"v":3.0525e-137,"d":"3.05E-137"},{"v":2.4486e-136,"d":"2.45E-136"},"down","yes","Ncf1","protein_coding","chr12:22485451-22494646:+","gi|939204643|sp|F1M707.2|NCF1_RAT",2003,0,"RecName: Full=Neutrophil cytosolic factor 1; Short=NCF-1","gi|40254741|ref|NM_053734.2|",2751,0,"Rattus norvegicus neutrophil cytosolic factor 1 (Ncf1), mRNA","F1M707",776,0,"Neutrophil cytosolic factor 1",".",".",".",".","pfam00787","PX","PX domain. PX domains bind to phosphoinositides.","GO:0001878|response to yeast;GO:0001909|leukocyte mediated cytotoxicity;GO:0002679|respiratory burst involved in defense response;GO:0006612|protein targeting to membrane;GO:0006691|leukotriene metabolic process;GO:0006915|apoptotic process;GO:0006954|inflammatory response;GO:0006968|cellular defense response;GO:0008283|cell proliferation;GO:0009617|response to bacterium;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0034614|cellular response to reactive oxygen species;GO:0042554|superoxide anion generation;GO:0042742|defense response to bacterium;GO:0045730|respiratory burst;GO:0045741|positive regulation of epidermal growth factor-activated receptor activity;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045986|negative regulation of smooth muscle contraction;GO:0046330|positive regulation of JNK cascade;GO:0050665|hydrogen peroxide biosynthetic process;GO:0050790|regulation of catalytic activity;GO:0050830|defense response to Gram-positive bacterium;GO:0050832|defense response to fungus;GO:0060264|regulation of respiratory burst involved in inflammatory response;GO:0070946|neutrophil mediated killing of gram-positive bacterium;GO:0070947|neutrophil mediated killing of fungus;GO:0071276|cellular response to cadmium ion;GO:1900745|positive regulation of p38MAPK cascade;GO:1903409|reactive oxygen species biosynthetic process;","GO:0005737|cytoplasm;GO:0005791|rough endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0019898|extrinsic component of membrane;GO:0030425|dendrite;GO:0043020|NADPH oxidase complex;GO:0043025|neuronal cell body;","GO:0016175|superoxide-generating NADPH oxidase activity;GO:0016176|superoxide-generating NADPH oxidase activator activity;GO:0017124|SH3 domain binding;GO:0035091|phosphatidylinositol binding;GO:0043325|phosphatidylinositol-3,4-bisphosphate binding;","K08011","NCF1, P47PHOX; neutrophil cytosolic factor 1"]
["ENSRNOG00000016678",487,31.3289234,1590,102.6533569,0.305191417,-1.712213707,{"v":8.4223e-137,"d":"8.42E-137"},{"v":6.737e-136,"d":"6.74E-136"},"down","yes","Angptl2","protein_coding","chr3:16517420-16548178:+","gi|149038973|gb|EDL93193.1|",2437,0,"angiopoietin-like 2 [Rattus norvegicus]","gi|19424253|ref|NM_133569.1|",1855,0,"Rattus norvegicus angiopoietin-like 2 (Angptl2), mRNA","Q9R045",941,0,"Angiopoietin-related protein 2",".",".",".",".","pfam00147","Fibrinogen_C","Fibrinogen beta and gamma chains, C-terminal globular domain.",".","GO:0005615|extracellular space;GO:0062023|collagen-containing extracellular matrix;","GO:0005102|signaling receptor binding;","K25359","ANGPTL2; angiopoietin-related protein 2"]
["ENSRNOG00000033266",2,0.128660876,670,43.25644597,2.974375E-3,-8.393197905,{"v":9.6833e-137,"d":"9.68E-137"},{"v":7.7348e-136,"d":"7.73E-136"},"down","yes","Prss30","protein_coding","chr10:13007341-13011030:-","gi|149051982|gb|EDM03799.1|",1574,0,"transmembrane protease, serine 8 (intestinal) [Rattus norvegicus]","gi|672066813|ref|XM_008767553.1|",1576,0,"PREDICTED: Rattus norvegicus protease, serine, 30 (Prss30), transcript variant X3, mRNA","P83748",585,0,"Serine protease 30","VC1649",117,{"v":3e-27,"d":"3.00E-27"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;GO:0006814|sodium ion transport;","GO:0005615|extracellular space;GO:0046658|anchored component of plasma membrane;","GO:0004252|serine-type endopeptidase activity;GO:0017080|sodium channel regulator activity;","K09639","TMPRSS8; transmembrane protease serine 8 [EC:3.4.21.-]"]
["ENSRNOG00000004578",166,10.67885274,960,61.97938527,0.172296848,-2.537031784,{"v":2.9363E-136,"d":"2.94E-136"},{"v":2.3422e-135,"d":"2.34E-135"},"down","yes","Cthrc1","protein_coding","chr7:70122474-70132756:+","gi|149066481|gb|EDM16354.1|",1305,{"v":1e-177,"d":"1.00E-177"},"collagen triple helix repeat containing 1 [Rattus norvegicus]","gi|404351656|ref|NM_172333.2|",1216,0,"Rattus norvegicus collagen triple helix repeat containing 1 (Cthrc1), transcript variant 1, mRNA","Q8CG08",468,{"v":4e-164,"d":"4.00E-164"},"Collagen triple helix repeat-containing protein 1",".",".",".",".","pfam01391","Collagen","Collagen triple helix repeat (20 copies). Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxyproline. Collagens are post translationally modified by proline hydroxylase to form the hydroxyproline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure.","GO:0016477|cell migration;GO:0032092|positive regulation of protein binding;GO:0033690|positive regulation of osteoblast proliferation;GO:0043932|ossification involved in bone remodeling;GO:0045669|positive regulation of osteoblast differentiation;GO:0060071|Wnt signaling pathway, planar cell polarity pathway;GO:0060122|inner ear receptor cell stereocilium organization;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0090103|cochlea morphogenesis;GO:0090177|establishment of planar polarity involved in neural tube closure;","GO:0005581|collagen trimer;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0031012|extracellular matrix;","GO:0005109|frizzled binding;GO:0017147|Wnt-protein binding;","K25700","CTHRC1; collagen triple helix repeat-containing protein 1"]
["ENSRNOG00000067705",386,24.83154914,1402,90.51572724,0.274334084,-1.865994216,{"v":7.6309e-136,"d":"7.63E-136"},{"v":6.07e-135,"d":"6.07E-135"},"down","yes","Klf2","protein_coding","chr16:17514552-17523944:-","gi|56090542|ref|NP_001007685.1|",1095,{"v":1e-130,"d":"1.00E-130"},"Krueppel-like factor 2 [Rattus norvegicus]","gi|170784839|ref|NM_008452.2|",1104,0,"Mus musculus Kruppel-like factor 2 (lung) (Klf2), mRNA","Q9ET58",426,{"v":3E-132,"d":"3.00E-132"},"Krueppel-like factor 2",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.",".",".",".",".","."]
["ENSRNOG00000011821",637,40.97848912,1836,118.5355743,0.345706252,-1.532381401,{"v":1.0711E-134,"d":"1.07E-134"},{"v":8.4615e-134,"d":"8.46E-134"},"down","yes","S100a4","protein_coding","chr2:176091804-176093254:+","gi|6981326|ref|NP_036750.1|",435,{"v":5E-52,"d":"5.00E-52"},"protein S100-A4 [Rattus norvegicus]","gi|672042871|ref|XM_006232592.2|",543,0,"PREDICTED: Rattus norvegicus S100 calcium-binding protein A4 (S100a4), transcript variant X1, mRNA","P05942",172,{"v":2e-53,"d":"2.00E-53"},"Protein S100-A4",".",".",".",".","pfam01023","S_100","S-100/ICaBP type calcium binding domain. The S-100 domain is a subfamily of the EF-hand calcium binding proteins.","GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;","GO:0005576|extracellular region;GO:0005634|nucleus;GO:0043005|neuron projection;GO:0048471|perinuclear region of cytoplasm;","GO:0003779|actin binding;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;GO:0046914|transition metal ion binding;GO:0048306|calcium-dependent protein binding;GO:0050786|RAGE receptor binding;","K23761","S100A4; protein S100-A4"]
["ENSRNOG00000004687",292,18.78448795,1215,78.44265948,0.23946776,-2.062096659,{"v":2.4128E-134,"d":"2.41E-134"},{"v":1.8981e-133,"d":"1.90E-133"},"down","yes","Thbd","protein_coding","chr3:135862835-135867193:-","gi|13929084|ref|NP_113959.1|",2885,0,"thrombomodulin precursor [Rattus norvegicus]","gi|47575867|ref|NM_031771.2|",3653,0,"Rattus norvegicus thrombomodulin (Thbd), mRNA","P15306",954,0,"Thrombomodulin",".",".",".",".","pfam09064","Tme5_EGF_like","Thrombomodulin like fifth domain, EGF-like. Members of this family adopt a fold similar to other EGF domains, with a flat major and a twisted minor beta sheet. Disulphide pairing, however, is not of the usual 1-3, 2-4, 5-6 type; rather 1-2, 3-4, 5-6 pairing is found. Its extended major sheet (strands beta-2 and beta-3 and the connecting loop) projects into thrombin's active site groove. This domain is required for interaction of thrombomodulin with thrombin, and subsequent activation of protein-C.","GO:0007565|female pregnancy;GO:0007596|blood coagulation;GO:0010165|response to X-ray;GO:0030195|negative regulation of blood coagulation;GO:0032496|response to lipopolysaccharide;GO:0051591|response to cAMP;","GO:0005615|extracellular space;GO:0005774|vacuolar membrane;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016327|apicolateral plasma membrane;","GO:0003674|molecular_function;GO:0004888|transmembrane signaling receptor activity;GO:0005509|calcium ion binding;","K03907","THBD, CD141; thrombomodulin"]
["ENSRNOG00000014170",1007,64.78075125,2423,156.4333859,0.414110779,-1.271911341,{"v":4.7467e-134,"d":"4.75E-134"},{"v":3.7137e-133,"d":"3.71E-133"},"down","yes","Dbn1","protein_coding","chr17:9150659-9164984:+","gi|564390568|ref|XP_006253717.1|",2494,0,"PREDICTED: drebrin isoform X1 [Rattus norvegicus]","gi|672081181|ref|XM_006253655.2|",3020,0,"PREDICTED: Rattus norvegicus drebrin 1 (Dbn1), transcript variant X1, mRNA","Q07266",961,0,"Drebrin",".",".",".",".","pfam00241","Cofilin_ADF","Cofilin/tropomyosin-type actin-binding protein. Severs actin filaments and binds to actin monomers.","GO:0001701|in utero embryonic development;GO:0007015|actin filament organization;GO:0007283|spermatogenesis;GO:0007399|nervous system development;GO:0007420|brain development;GO:0007568|aging;GO:0009410|response to xenobiotic stimulus;GO:0010643|cell communication by chemical coupling;GO:0010644|cell communication by electrical coupling;GO:0010811|positive regulation of cell-substrate adhesion;GO:0010976|positive regulation of neuron projection development;GO:0014823|response to activity;GO:0030833|regulation of actin filament polymerization;GO:0031915|positive regulation of synaptic plasticity;GO:0032232|negative regulation of actin filament bundle assembly;GO:0032507|maintenance of protein location in cell;GO:0045773|positive regulation of axon extension;GO:0048286|lung alveolus development;GO:0048699|generation of neurons;GO:0048812|neuron projection morphogenesis;GO:0051220|cytoplasmic sequestering of protein;GO:0051489|regulation of filopodium assembly;GO:0060134|prepulse inhibition;GO:0061003|positive regulation of dendritic spine morphogenesis;GO:0061351|neural precursor cell proliferation;GO:0071356|cellular response to tumor necrosis factor;GO:0071481|cellular response to X-ray;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0090327|negative regulation of locomotion involved in locomotory behavior;GO:0098828|modulation of inhibitory postsynaptic potential;GO:0098974|postsynaptic actin cytoskeleton organization;GO:1900026|positive regulation of substrate adhesion-dependent cell spreading;GO:1902685|positive regulation of receptor localization to synapse;GO:1902897|regulation of postsynaptic density protein 95 clustering;GO:1904113|negative regulation of muscle filament sliding;GO:2000463|positive regulation of excitatory postsynaptic potential;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0005921|gap junction;GO:0014069|postsynaptic density;GO:0015629|actin cytoskeleton;GO:0016020|membrane;GO:0030027|lamellipodium;GO:0030175|filopodium;GO:0030425|dendrite;GO:0030426|growth cone;GO:0030427|site of polarized growth;GO:0030864|cortical actin cytoskeleton;GO:0032279|asymmetric synapse;GO:0043025|neuronal cell body;GO:0043197|dendritic spine;GO:0043198|dendritic shaft;GO:0044295|axonal growth cone;GO:0044308|axonal spine;GO:0044309|neuron spine;GO:0045211|postsynaptic membrane;GO:0048471|perinuclear region of cytoplasm;GO:0060076|excitatory synapse;GO:0098871|postsynaptic actin cytoskeleton;GO:0098978|glutamatergic synapse;GO:0099524|postsynaptic cytosol;GO:1902737|dendritic filopodium;","GO:0003779|actin binding;GO:0005515|protein binding;GO:0005522|profilin binding;GO:0008092|cytoskeletal protein binding;GO:0051015|actin filament binding;","K25391","DBN1; drebrin"]
["ENSRNOG00000012991",1069,68.76923842,2517,162.5022008,0.423189582,-1.240623983,{"v":6.2455e-134,"d":"6.25E-134"},{"v":4.8796e-133,"d":"4.88E-133"},"down","yes","Adgra2","protein_coding","chr16:64933315-64971483:-","gi|564319106|ref|XP_003752966.2|",6468,0,"PREDICTED: G-protein coupled receptor 124 isoform X1 [Rattus norvegicus]","gi|672080455|ref|XM_003751617.3|",5427,0,"PREDICTED: Rattus norvegicus G protein-coupled receptor 124 (LOC100363275), transcript variant X1, mRNA","Q91ZV8",2344,0,"Adhesion G protein-coupled receptor A2","SPy1798",53.5,8e-06,"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0001525|angiogenesis;GO:0002040|sprouting angiogenesis;GO:0007166|cell surface receptor signaling pathway;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007417|central nervous system development;GO:0010595|positive regulation of endothelial cell migration;GO:0043542|endothelial cell migration;GO:0045765|regulation of angiogenesis;GO:0050920|regulation of chemotaxis;GO:0090210|regulation of establishment of blood-brain barrier;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:1900747|negative regulation of vascular endothelial growth factor signaling pathway;","GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:1990909|Wnt signalosome;","GO:0004930|G protein-coupled receptor activity;","K08461","ADGRA2, GPR124; adhesion G protein-coupled receptor A2"]
["ENSRNOG00000007364",12,0.771965258,560,36.15464141,0.021351761,-5.549501136,{"v":6.5219e-134,"d":"6.52E-134"},{"v":5.0886e-133,"d":"5.09E-133"},"down","yes","Rab15","protein_coding","chr6:95499587-95523942:-","gi|38454238|ref|NP_942044.1|",1063,{"v":3e-133,"d":"3.00E-133"},"ras-related protein Rab-15 [Rattus norvegicus]","gi|66955887|ref|NM_198749.2|",3388,0,"Rattus norvegicus RAB15, member RAS oncogene family (Rab15), mRNA","P35289",414,{"v":1E-134,"d":"1.00E-134"},"Ras-related protein Rab-15",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0006904|vesicle docking involved in exocytosis;GO:0007269|neurotransmitter secretion;GO:0009306|protein secretion;GO:0017157|regulation of exocytosis;GO:0032482|Rab protein signal transduction;GO:0032869|cellular response to insulin stimulus;GO:0072659|protein localization to plasma membrane;GO:1903307|positive regulation of regulated secretory pathway;","GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005929|cilium;GO:0008021|synaptic vesicle;GO:0010008|endosome membrane;GO:0016020|membrane;GO:0032593|insulin-responsive compartment;GO:0048471|perinuclear region of cytoplasm;GO:0055037|recycling endosome;","GO:0003924|GTPase activity;GO:0005525|GTP binding;","K07908","RAB15; Ras-related protein Rab-15"]
["ENSRNOG00000021474",33,2.12290446,609,39.31817253,0.053992959,-4.211084918,{"v":2.3509E-133,"d":"2.35E-133"},{"v":1.8293e-132,"d":"1.83E-132"},"down","yes","Siglec5","protein_coding","chr1:93768319-93776694:+","gi|564327829|ref|XP_006229008.1|",2946,0,"PREDICTED: sialic acid-binding Ig-like lectin 5 isoform X3 [Rattus norvegicus]","gi|164663859|ref|NM_001106249.2|",2466,0,"Rattus norvegicus sialic acid binding Ig-like lectin 5 (Siglec5), mRNA","Q920G3",866,0,"Sialic acid-binding Ig-like lectin 5",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0007155|cell adhesion;GO:0030100|regulation of endocytosis;","GO:0005764|lysosome;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0033691|sialic acid binding;GO:0048029|monosaccharide binding;","K06549","SIGLEC5, CD170; sialic acid binding Ig-like lectin 5"]
["ENSRNOG00000016248",466,29.97798419,1534,99.03789271,0.302692064,-1.724077242,{"v":2.5466E-133,"d":"2.55E-133"},{"v":1.9788e-132,"d":"1.98E-132"},"down","yes","Sox18","protein_coding","chr3:168785490-168787290:-","gi|67078462|ref|NP_001019952.1|",1374,0,"transcription factor SOX-18 [Rattus norvegicus]","gi|67078461|ref|NM_001024781.1|",1617,0,"Rattus norvegicus SRY box 18 (Sox18), mRNA","P43680",516,{"v":4e-179,"d":"4.00E-179"},"Transcription factor SOX-18",".",".",".",".","pfam12067","Sox_C_TAD","Sox C-terminal transactivation domain. This domain is found at the C-terminus of the Sox family of transcription factors. It is found associated with pfam00505. It binds to the Armadillo repeats (pfam00514) in Catenin beta-1 (CTNNB1), which is involved in transcriptional regulation. It functions as a transactivating domain (TAD).","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001525|angiogenesis;GO:0001568|blood vessel development;GO:0001570|vasculogenesis;GO:0001701|in utero embryonic development;GO:0001942|hair follicle development;GO:0001944|vasculature development;GO:0001945|lymph vessel development;GO:0001946|lymphangiogenesis;GO:0006355|regulation of transcription, DNA-templated;GO:0007507|heart development;GO:0008150|biological_process;GO:0009653|anatomical structure morphogenesis;GO:0022405|hair cycle process;GO:0030154|cell differentiation;GO:0035050|embryonic heart tube development;GO:0043534|blood vessel endothelial cell migration;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048469|cell maturation;GO:0048866|stem cell fate specification;GO:0060214|endocardium formation;GO:0060836|lymphatic endothelial cell differentiation;GO:0060956|endocardial cell differentiation;GO:0061028|establishment of endothelial barrier;GO:0072091|regulation of stem cell proliferation;","GO:0000785|chromatin;GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09270","SOX7S; transcription factor SOX7/8/10/18 (SOX group E/F)"]
["ENSRNOG00000022839",57,3.666834977,675,43.57925527,0.084141754,-3.571034297,{"v":1.065E-132,"d":"1.07E-132"},{"v":8.2645e-132,"d":"8.26E-132"},"down","yes","Ifit3","protein_coding","chr1:232114166-232119307:+","gi|56090427|ref|NP_001007695.1|",2187,0,"interferon-induced protein with tetratricopeptide repeats 3 [Rattus norvegicus]","gi|56090426|ref|NM_001007694.1|",1989,0,"Rattus norvegicus interferon-induced protein with tetratricopeptide repeats 3 (Ifit3), mRNA","Q64345",688,0,"Interferon-induced protein with tetratricopeptide repeats 3",".",".",".",".","pfam13424","TPR_12","Tetratricopeptide repeat.","GO:0008285|negative regulation of cell proliferation;GO:0009615|response to virus;GO:0009617|response to bacterium;GO:0035457|cellular response to interferon-alpha;GO:0035458|cellular response to interferon-beta;GO:0035634|response to stilbenoid;GO:0043066|negative regulation of apoptotic process;GO:0051607|defense response to virus;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;","GO:0003723|RNA binding;GO:0042802|identical protein binding;","K24849","IFIT3; interferon-induced protein with tetratricopeptide repeats 3"]
["ENSRNOG00000008215",205,13.18773983,1029,66.43415359,0.198508435,-2.332727787,{"v":1.364e-132,"d":"1.36E-132"},{"v":1.0571e-131,"d":"1.06E-131"},"down","yes","Trim47","protein_coding","chr10:101337573-101342044:-","gi|157818923|ref|NP_001103055.1|",2610,0,"tripartite motif-containing protein 47 [Rattus norvegicus]","gi|157818922|ref|NM_001109585.1|",2198,0,"Rattus norvegicus tripartite motif-containing 47 (Trim47), mRNA","Q8C0E3",979,0,"Tripartite motif-containing protein 47",".",".",".",".","pfam15227","zf-C3HC4_4","zinc finger of C3HC4-type, RING. This is a family of primate-specific Ret finger protein-like (RFPL) zinc-fingers of the C3HC4 type. Ret finger protein-like proteins are primate-specific target genes of Pax6, a key transcription factor for pancreas, eye and neocortex development. This domain is likely to be DNA-binding. This zinc-finger domain together with the RDM domain, pfam11002, forms a large zinc-finger structure of the RING/U-Box superfamily. RING-containing proteins are known to exert an E3 ubiquitin protein ligase activity with the zinc-finger structure being mandatory for binding to the E2 ubiquitin-conjugating enzyme.","GO:0016567|protein ubiquitination;","GO:0005829|cytosol;","GO:0004842|ubiquitin-protein transferase activity;GO:0008270|zinc ion binding;","K12023","TRIM47; tripartite motif-containing protein 47"]
["ENSRNOG00000019965",403,25.92516659,1416,91.41959327,0.283584357,-1.818150141,{"v":1.751e-132,"d":"1.75E-132"},{"v":1.3551e-131,"d":"1.36E-131"},"down","yes","Tgfb1i1","protein_coding","chr1:182828544-182837080:+","gi|300797521|ref|NP_001178769.1|",2135,0,"transforming growth factor beta-1-induced transcript 1 protein [Rattus norvegicus]","gi|575501560|ref|NM_001289550.1|",2044,0,"Mus musculus transforming growth factor beta 1 induced transcript 1 (Tgfb1i1), transcript variant 1, mRNA","Q99PD6",806,0,"Transforming growth factor beta-1-induced transcript 1 protein",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.","GO:0009408|response to heat;GO:0010718|positive regulation of epithelial to mesenchymal transition;GO:0016055|Wnt signaling pathway;GO:0016331|morphogenesis of embryonic epithelium;GO:0030511|positive regulation of transforming growth factor beta receptor signaling pathway;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030579|ubiquitin-dependent SMAD protein catabolic process;GO:0030855|epithelial cell differentiation;GO:0045165|cell fate commitment;GO:0045599|negative regulation of fat cell differentiation;GO:0045893|positive regulation of transcription, DNA-templated;","GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0005925|focal adhesion;GO:0016363|nuclear matrix;","GO:0003712|transcription coregulator activity;GO:0003713|transcription coactivator activity;GO:0005515|protein binding;GO:0046872|metal ion binding;GO:0048495|Roundabout binding;GO:0050681|androgen receptor binding;GO:0070411|I-SMAD binding;","K24315","TGFB1I1; transforming growth factor beta-1-induced transcript 1 protein"]
["ENSRNOG00000013426",32,2.058574022,601,38.80167765,0.053053738,-4.2364018,{"v":4.7811e-132,"d":"4.78E-132"},{"v":3.6851e-131,"d":"3.69E-131"},"down","yes","Mrgprf","protein_coding","chr1:200463973-200473660:+","gi|148686343|gb|EDL18290.1|",1681,0,"MAS-related GPR, member F, isoform CRA_a, partial [Mus musculus]","gi|157743354|gb|AC097959.7|",1886,0,"Rattus norvegicus BAC CH230-114G10 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P23749",646,0,"Mas-related G-protein coupled receptor member F",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0031965|nuclear membrane;","GO:0004930|G protein-coupled receptor activity;","K08394","MRGPRF; Mas-related G protein-coupled receptor member F"]
["ENSRNOG00000004222",12,0.771965258,547,35.31533723,0.021859207,-5.515615141,{"v":8.7463e-131,"d":"8.75E-131"},{"v":6.7322e-130,"d":"6.73E-130"},"down","yes","S100g","protein_coding","chrX:31705866-31708433:+","gi|564399101|ref|XP_006256950.1|",362,{"v":1E-41,"d":"1.00E-41"},"PREDICTED: protein S100-G isoform X1 [Rattus norvegicus]","gi|672087298|ref|XM_006256888.2|",439,0,"PREDICTED: Rattus norvegicus S100 calcium binding protein G (S100g), transcript variant X1, mRNA","P02634",137,{"v":1e-40,"d":"1.00E-40"},"Protein S100-G",".",".",".",".","pfam01023","S_100","S-100/ICaBP type calcium binding domain. The S-100 domain is a subfamily of the EF-hand calcium binding proteins.","GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;","GO:0003674|molecular_function;GO:0005499|vitamin D binding;GO:0005509|calcium ion binding;GO:0046914|transition metal ion binding;GO:0048306|calcium-dependent protein binding;","K14734","S100G; protein S100-G"]
["ENSRNOG00000000853",311,20.00676628,1233,79.60477295,0.251326215,-1.992366934,{"v":1.9249e-130,"d":"1.92E-130"},{"v":1.4756E-129,"d":"1.48E-129"},"down","yes","Aif1","protein_coding","chr20:3646777-3652668:+","gi|564396944|ref|XP_006256123.1|",572,{"v":1e-65,"d":"1.00E-65"},"PREDICTED: allograft inflammatory factor 1 isoform X1 [Rattus norvegicus]","gi|1049210|gb|U33471.1|RNU33471",1495,0,"Rattus norvegicus balloon angioplasty responsive transcript (BART-1) mRNA, complete cds","P55009",170,{"v":4e-48,"d":"4.00E-48"},"Allograft inflammatory factor 1",".",".",".",".","pfam05110","AF-4","AF-4 proto-oncoprotein. This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.","GO:0001934|positive regulation of protein phosphorylation;GO:0006911|phagocytosis, engulfment;GO:0006954|inflammatory response;GO:0008284|positive regulation of cell proliferation;GO:0010629|negative regulation of gene expression;GO:0014739|positive regulation of muscle hyperplasia;GO:0016601|Rac protein signal transduction;GO:0021549|cerebellum development;GO:0030041|actin filament polymerization;GO:0030046|parallel actin filament bundle assembly;GO:0030335|positive regulation of cell migration;GO:0031668|cellular response to extracellular stimulus;GO:0032722|positive regulation of chemokine production;GO:0032755|positive regulation of interleukin-6 production;GO:0032870|cellular response to hormone stimulus;GO:0034097|response to cytokine;GO:0034599|cellular response to oxidative stress;GO:0042102|positive regulation of T cell proliferation;GO:0042116|macrophage activation;GO:0043066|negative regulation of apoptotic process;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0048662|negative regulation of smooth muscle cell proliferation;GO:0048678|response to axon injury;GO:0050921|positive regulation of chemotaxis;GO:0051017|actin filament bundle assembly;GO:0051384|response to glucocorticoid;GO:0051602|response to electrical stimulus;GO:0051764|actin crosslink formation;GO:0071315|cellular response to morphine;GO:0071346|cellular response to interferon-gamma;GO:0071447|cellular response to hydroperoxide;GO:0071672|negative regulation of smooth muscle cell chemotaxis;GO:0071673|positive regulation of smooth muscle cell chemotaxis;GO:0071677|positive regulation of mononuclear cell migration;GO:0090026|positive regulation of monocyte chemotaxis;GO:0090271|positive regulation of fibroblast growth factor production;GO:0097178|ruffle assembly;GO:1900087|positive regulation of G1/S transition of mitotic cell cycle;GO:2000406|positive regulation of T cell migration;","GO:0001726|ruffle;GO:0001891|phagocytic cup;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005884|actin filament;GO:0030027|lamellipodium;GO:0032587|ruffle membrane;GO:0042995|cell projection;GO:0043204|perikaryon;GO:0048471|perinuclear region of cytoplasm;","GO:0005509|calcium ion binding;GO:0051015|actin filament binding;","K18617","AIF1; allograft inflammatory factor 1"]
["ENSRNOG00000012874",204,13.12340939,1015,65.53028755,0.200264792,-2.320019289,{"v":5.6104e-130,"d":"5.61E-130"},{"v":4.2724e-129,"d":"4.27E-129"},"down","yes","Rgma","protein_coding","chr1:127128934-127172918:+","gi|672037054|ref|XP_008757743.1|",2055,0,"PREDICTED: repulsive guidance molecule A isoform X1 [Rattus norvegicus]","gi|672037053|ref|XM_008759521.1|",4932,0,"PREDICTED: Rattus norvegicus repulsive guidance molecule family member A (Rgma), transcript variant X1, mRNA","Q6PCX7",698,0,"Repulsive guidance molecule A",".",".",".",".","pfam06534","RGM_C","Repulsive guidance molecule (RGM) C-terminus. This family consists of several mammalian and one bird sequence from Gallus gallus (Chicken). This family represents the C-terminal region of several sequences but in others it represents the full protein. All of the mammalian proteins are hypothetical and have no known function but RGMA from the chicken is annotated as being a repulsive guidance molecule (RGM). RGM is a GPI-linked axon guidance molecule of the retinotectal system. RGM is repulsive for a subset of axons, those from the temporal half of the retina. Temporal retinal axons invade the anterior optic tectum in a superficial layer, and encounter RGM expressed in a gradient with increasing concentration along the anterior-posterior axis. Temporal axons are able to receive posterior-dependent information by sensing gradients or concentrations of guidance cues. Thus, RGM is likely to provide positional information for temporal axons invading the optic tectum in the stratum opticum.","GO:0001843|neural tube closure;GO:0010976|positive regulation of neuron projection development;GO:0010977|negative regulation of neuron projection development;GO:0030509|BMP signaling pathway;GO:0030510|regulation of BMP signaling pathway;GO:0031175|neuron projection development;GO:0043547|positive regulation of GTPase activity;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048671|negative regulation of collateral sprouting;GO:0048681|negative regulation of axon regeneration;GO:0051044|positive regulation of membrane protein ectodomain proteolysis;GO:1900121|negative regulation of receptor binding;","GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0031225|anchored component of membrane;GO:0043005|neuron projection;","GO:0003674|molecular_function;GO:0005102|signaling receptor binding;GO:0015026|coreceptor activity;GO:1990459|transferrin receptor binding;","K23096","RGMA; repulsive guidance molecule A"]
["ENSRNOG00000028569",370,23.80226213,1339,86.44833008,0.275335129,-1.860739404,{"v":2.4242e-129,"d":"2.42E-129"},{"v":1.8387e-128,"d":"1.84E-128"},"down","yes","Arhgap27","protein_coding","chr10:88280455-88313185:-","gi|564374718|ref|XP_006247585.1|",4290,0,"PREDICTED: rho GTPase-activating protein 27 isoform X1 [Rattus norvegicus]","gi|672069532|ref|XM_006247523.2|",4508,0,"PREDICTED: Rattus norvegicus Rho GTPase activating protein 27 (Arhgap27), transcript variant X2, mRNA","Q6TLK4",1652,0,"Rho GTPase-activating protein 27",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0006898|receptor-mediated endocytosis;GO:0007165|signal transduction;GO:0043087|regulation of GTPase activity;GO:0043547|positive regulation of GTPase activity;","GO:0005737|cytoplasm;GO:0005768|endosome;GO:0016020|membrane;","GO:0005096|GTPase activator activity;GO:0005515|protein binding;GO:0017124|SH3 domain binding;","K20636","ARHGAP12_27; Rho GTPase-activating protein 12/27"]
["ENSRNOG00000009822",34,2.187234898,595,38.41430649,0.056938029,-4.134463636,{"v":4.8939e-129,"d":"4.89E-129"},{"v":3.707e-128,"d":"3.71E-128"},"down","yes","Tlr2","protein_coding","chr2:169197419-169206630:-","gi|672042714|ref|XP_008759324.1|",3768,0,"PREDICTED: toll-like receptor 2 isoform X1 [Rattus norvegicus]","gi|672042713|ref|XM_008761102.1|",3103,0,"PREDICTED: Rattus norvegicus toll-like receptor 2 (Tlr2), transcript variant X1, mRNA","Q9QUN7",1299,0,"Toll-like receptor 2",".",".",".",".","pfam01582","TIR","TIR domain. The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.","GO:0001666|response to hypoxia;GO:0001774|microglial cell activation;GO:0001775|cell activation;GO:0001819|positive regulation of cytokine production;GO:0002224|toll-like receptor signaling pathway;GO:0002238|response to molecule of fungal origin;GO:0002687|positive regulation of leukocyte migration;GO:0002730|regulation of dendritic cell cytokine production;GO:0002752|cell surface pattern recognition receptor signaling pathway;GO:0002755|MyD88-dependent toll-like receptor signaling pathway;GO:0006691|leukotriene metabolic process;GO:0006952|defense response;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007252|I-kappaB phosphorylation;GO:0007612|learning;GO:0008285|negative regulation of cell proliferation;GO:0009617|response to bacterium;GO:0009636|response to toxic substance;GO:0010628|positive regulation of gene expression;GO:0014005|microglia development;GO:0030177|positive regulation of Wnt signaling pathway;GO:0030837|negative regulation of actin filament polymerization;GO:0032289|central nervous system myelin formation;GO:0032493|response to bacterial lipoprotein;GO:0032494|response to peptidoglycan;GO:0032496|response to lipopolysaccharide;GO:0032570|response to progesterone;GO:0032695|negative regulation of interleukin-12 production;GO:0032700|negative regulation of interleukin-17 production;GO:0032722|positive regulation of chemokine production;GO:0032728|positive regulation of interferon-beta production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032733|positive regulation of interleukin-10 production;GO:0032735|positive regulation of interleukin-12 production;GO:0032741|positive regulation of interleukin-18 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032868|response to insulin;GO:0034123|positive regulation of toll-like receptor signaling pathway;GO:0034134|toll-like receptor 2 signaling pathway;GO:0042495|detection of triacyl bacterial lipopeptide;GO:0042496|detection of diacyl bacterial lipopeptide;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046209|nitric oxide metabolic process;GO:0048714|positive regulation of oligodendrocyte differentiation;GO:0050729|positive regulation of inflammatory response;GO:0050765|negative regulation of phagocytosis;GO:0050830|defense response to Gram-positive bacterium;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051607|defense response to virus;GO:0051770|positive regulation of nitric-oxide synthase biosynthetic process;GO:0051964|negative regulation of synapse assembly;GO:0060907|positive regulation of macrophage cytokine production;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070542|response to fatty acid;GO:0071221|cellular response to bacterial lipopeptide;GO:0071223|cellular response to lipoteichoic acid;GO:0071224|cellular response to peptidoglycan;GO:0071346|cellular response to interferon-gamma;GO:0071726|cellular response to diacyl bacterial lipopeptide;GO:0071727|cellular response to triacyl bacterial lipopeptide;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1903974|positive regulation of cellular response to macrophage colony-stimulating factor stimulus;GO:1904417|positive regulation of xenophagy;GO:1904466|positive regulation of matrix metallopeptidase secretion;","GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0030670|phagocytic vesicle membrane;GO:0031226|intrinsic component of plasma membrane;GO:0035354|Toll-like receptor 1-Toll-like receptor 2 protein complex;GO:0035355|Toll-like receptor 2-Toll-like receptor 6 protein complex;GO:0042995|cell projection;GO:0044297|cell body;GO:0045121|membrane raft;","GO:0001530|lipopolysaccharide binding;GO:0001540|amyloid-beta binding;GO:0003953|NAD+ nucleosidase activity;GO:0004888|transmembrane signaling receptor activity;GO:0005515|protein binding;GO:0035325|Toll-like receptor binding;GO:0038023|signaling receptor activity;GO:0038187|pattern recognition receptor activity;GO:0042497|triacyl lipopeptide binding;GO:0042498|diacyl lipopeptide binding;GO:0042802|identical protein binding;GO:0042834|peptidoglycan binding;GO:0044877|protein-containing complex binding;GO:0070891|lipoteichoic acid binding;GO:0071723|lipopeptide binding;","K10159","TLR2, CD282; toll-like receptor 2"]
["ENSRNOG00000009912",38,2.444556651,605,39.05992509,0.062584776,-3.998044438,{"v":1.2308E-128,"d":"1.23E-128"},{"v":9.298e-128,"d":"9.30E-128"},"down","yes","Fgr","protein_coding","chr5:145189841-145217326:+","gi|564353313|ref|XP_006239140.1|",2763,0,"PREDICTED: tyrosine-protein kinase Fgr isoform X2 [Rattus norvegicus]","gi|40254760|ref|NM_024145.2|",2480,0,"Rattus norvegicus FGR proto-oncogene, Src family tyrosine kinase (Fgr), mRNA","Q6P6U0",1056,0,"Tyrosine-protein kinase Fgr","BH2504_1",98.2,{"v":4e-21,"d":"4.00E-21"},"COG0515","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001819|positive regulation of cytokine production;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007229|integrin-mediated signaling pathway;GO:0008150|biological_process;GO:0008360|regulation of cell shape;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0030154|cell differentiation;GO:0030282|bone mineralization;GO:0030335|positive regulation of cell migration;GO:0032815|negative regulation of natural killer cell activation;GO:0043306|positive regulation of mast cell degranulation;GO:0043552|positive regulation of phosphatidylinositol 3-kinase activity;GO:0045087|innate immune response;GO:0045088|regulation of innate immune response;GO:0045859|regulation of protein kinase activity;GO:0046777|protein autophosphorylation;GO:0048705|skeletal system morphogenesis;GO:0050764|regulation of phagocytosis;GO:0050830|defense response to Gram-positive bacterium;","GO:0005743|mitochondrial inner membrane;GO:0005758|mitochondrial intermembrane space;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0015629|actin cytoskeleton;GO:0016235|aggresome;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0032587|ruffle membrane;","GO:0001784|phosphotyrosine residue binding;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0005102|signaling receptor binding;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0019901|protein kinase binding;GO:0034987|immunoglobulin receptor binding;GO:0034988|Fc-gamma receptor I complex binding;","K08891","FGR, SRC2; tyrosine-protein kinase Fgr [EC:2.7.10.2]"]
["ENSRNOG00000014258",152,9.778226604,894,57.71830253,0.169412928,-2.561384127,{"v":2.2792E-128,"d":"2.28E-128"},{"v":1.7173e-127,"d":"1.72E-127"},"down","yes","Rab32","lncRNA","chr1:4945036-4960934:-","gi|157820973|ref|NP_001102372.1|",864,{"v":3E-102,"d":"3.00E-102"},"ras-related protein Rab-32 [Rattus norvegicus]","gi|157820972|ref|NM_001108902.1|",1406,0,"Rattus norvegicus RAB32, member RAS oncogene family (Rab32), mRNA","Q9CZE3",322,{"v":2e-98,"d":"2.00E-98"},"Ras-related protein Rab-32",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0006886|intracellular protein transport;GO:0007005|mitochondrion organization;GO:0016192|vesicle-mediated transport;GO:0019882|antigen processing and presentation;GO:0032438|melanosome organization;GO:0035646|endosome to melanosome transport;GO:0072657|protein localization to membrane;GO:0090382|phagosome maturation;GO:1903232|melanosome assembly;","GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0005769|early endosome;GO:0005783|endoplasmic reticulum;GO:0005802|trans-Golgi network;GO:0012505|endomembrane system;GO:0016020|membrane;GO:0033162|melanosome membrane;GO:0042470|melanosome;GO:0044233|Mitochondria-associated ER Membrane;GO:0045335|phagocytic vesicle;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0030742|GTP-dependent protein binding;GO:0035650|AP-1 adaptor complex binding;GO:0035651|AP-3 adaptor complex binding;GO:0036461|BLOC-2 complex binding;","K07918","RAB32; Ras-related protein Rab-32"]
["ENSRNOG00000019179",256,16.46859218,1114,71.92191166,0.228978788,-2.126714137,{"v":3.3041e-128,"d":"3.30E-128"},{"v":2.4862E-127,"d":"2.49E-127"},"down","yes","Ggta1","protein_coding","chr3:18732991-18809908:-","gi|149038922|gb|EDL93142.1|",2021,0,"glycoprotein galactosyltransferase alpha 1, 3, isoform CRA_b [Rattus norvegicus]","gi|672045123|ref|XM_008761702.1|",2826,0,"PREDICTED: Rattus norvegicus glycoprotein, alpha-galactosyltransferase 1,3 (Ggta1p), transcript variant X5, mRNA","Q3L7M0",692,0,"N-acetyllactosaminide alpha-1,3-galactosyltransferase",".",".",".",".","pfam03414","Glyco_transf_6","Glycosyltransferase family 6.","GO:0005975|carbohydrate metabolic process;GO:0033580|protein galactosylation at cell surface;","GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;GO:0031982|vesicle;GO:0031985|Golgi cisterna;GO:0032580|Golgi cisterna membrane;","GO:0016757|transferase activity, transferring glycosyl groups;GO:0016758|transferase activity, transferring hexosyl groups;GO:0046872|metal ion binding;GO:0047276|N-acetyllactosaminide 3-alpha-galactosyltransferase activity;","K00743","GGTA1; N-acetyllactosaminide 3-alpha-galactosyltransferase [EC:2.4.1.87]"]
["ENSRNOG00000013220",369,23.73793169,1331,85.9318352,0.276241414,-1.855998469,{"v":3.8247e-128,"d":"3.82E-128"},{"v":2.8742e-127,"d":"2.87E-127"},"down","yes","Arhgap45","protein_coding","chr7:9674897-9690268:-","gi|157820943|ref|NP_001101537.1|",5119,0,"minor histocompatibility protein HA-1 [Rattus norvegicus]","gi|157820942|ref|NM_001108067.1|",3883,0,"Rattus norvegicus histocompatibility (minor) HA-1 (Hmha1), mRNA","Q3TBD2",1873,0,"Rho GTPase-activating protein 45",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0035556|intracellular signal transduction;GO:0090630|activation of GTPase activity;",".","GO:0005096|GTPase activator activity;","K20644","ARHGAP29_45; Rho GTPase-activating protein 29/45"]
["ENSRNOG00000004367",939,60.40628146,2278,147.0719163,0.410726147,-1.283751303,{"v":5.9638e-128,"d":"5.96E-128"},{"v":4.4758e-127,"d":"4.48E-127"},"down","yes","Elk3","protein_coding","chr7:27768599-27804084:-","gi|157823996|ref|NP_001102213.1|",1383,{"v":7E-176,"d":"7.00E-176"},"ETS domain-containing protein Elk-3 [Rattus norvegicus]","gi|672058283|ref|XM_006241265.2|",3825,0,"PREDICTED: Rattus norvegicus ELK3, member of ETS oncogene family (Elk3), transcript variant X1, mRNA","P41971",524,{"v":2e-172,"d":"2.00E-172"},"ETS domain-containing protein Elk-3",".",".",".",".","pfam00178","Ets","Ets-domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001525|angiogenesis;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0030154|cell differentiation;GO:0042060|wound healing;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005739|mitochondrion;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0032422|purine-rich negative regulatory element binding;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09430","ELK3; ETS domain-containing protein Elk-3 (SRF accessory protein 2)"]
["ENSRNOG00000058422",374,24.05958388,1338,86.38376822,0.278519731,-1.84414856,{"v":1.0424e-127,"d":"1.04E-127"},{"v":7.7923e-127,"d":"7.79E-127"},"down","yes","Lilrb3a","protein_coding","chr1:65499195-65506666:+","gi|392334665|ref|XP_001066042.3|",4234,0,"PREDICTED: leukocyte immunoglobulin-like receptor subfamily B member 3 isoform X1 [Rattus norvegicus]","gi|672013024|ref|XM_001066042.5|",2787,0,"PREDICTED: Rattus norvegicus similar to paired-Ig-like receptor B (LOC690955), transcript variant X1, mRNA","A0A0G2KBC9",1259,0,"Leukocyte immunoglobulin-like receptor subfamily B member 3-like",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0001782|B cell homeostasis;GO:0002250|adaptive immune response;GO:0007611|learning or memory;GO:0019221|cytokine-mediated signaling pathway;GO:0019724|B cell mediated immunity;GO:0035307|positive regulation of protein dephosphorylation;GO:0043011|myeloid dendritic cell differentiation;GO:0045671|negative regulation of osteoclast differentiation;GO:0051248|negative regulation of protein metabolic process;GO:1900271|regulation of long-term synaptic potentiation;GO:1900454|positive regulation of long-term synaptic depression;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0001540|amyloid-beta binding;GO:0032396|inhibitory MHC class I receptor activity;GO:0042803|protein homodimerization activity;GO:0044877|protein-containing complex binding;",".","."]
["ENSRNOG00000000700",77,4.95344374,709,45.7743585,0.108214378,-3.208035896,{"v":1.2086e-127,"d":"1.21E-127"},{"v":9.0112e-127,"d":"9.01E-127"},"down","yes","Tmem119","protein_coding","chr12:42828418-42835689:+","gi|564379810|ref|XP_006249562.1|",1512,0,"PREDICTED: transmembrane protein 119 isoform X1 [Rattus norvegicus]","gi|672073351|ref|XM_006249500.2|",2291,0,"PREDICTED: Rattus norvegicus transmembrane protein 119 (Tmem119), transcript variant X1, mRNA","Q8R138",359,{"v":7e-116,"d":"7.00E-116"},"Transmembrane protein 119",".",".",".",".","pfam05210","Sprouty","Sprouty protein (Spry). This family consists of eukaryotic Sprouty protein homologues. Sprouty proteins have been revealed as inhibitors of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases. The sprouty gene has found to be expressed in the the brain, cochlea, nasal organs, teeth, salivary gland, lungs, digestive tract, kidneys and limb buds in mice.","GO:0001649|osteoblast differentiation;GO:0001934|positive regulation of protein phosphorylation;GO:0001958|endochondral ossification;GO:0007283|spermatogenesis;GO:0008150|biological_process;GO:0010628|positive regulation of gene expression;GO:0010832|negative regulation of myotube differentiation;GO:0030501|positive regulation of bone mineralization;GO:0033690|positive regulation of osteoblast proliferation;GO:0045669|positive regulation of osteoblast differentiation;GO:0045779|negative regulation of bone resorption;GO:0048515|spermatid differentiation;GO:1903012|positive regulation of bone development;","GO:0005575|cellular_component;GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;",".","."]
["ENSRNOG00000009227",345,22.19400117,1283,82.83286594,0.26793714,-1.900033523,{"v":1.6742E-127,"d":"1.67E-127"},{"v":1.2466E-126,"d":"1.25E-126"},"down","yes","Aplnr","protein_coding","chr3:70217385-70221050:+","gi|13786192|ref|NP_112639.1|",1693,0,"apelin receptor [Rattus norvegicus]","gi|48675846|ref|NM_031349.2|",3644,0,"Rattus norvegicus apelin receptor (Aplnr), mRNA","Q9JHG3",656,0,"Apelin receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001525|angiogenesis;GO:0001568|blood vessel development;GO:0001570|vasculogenesis;GO:0001944|vasculature development;GO:0001947|heart looping;GO:0003171|atrioventricular valve development;GO:0003272|endocardial cushion formation;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007369|gastrulation;GO:0007507|heart development;GO:0007512|adult heart development;GO:0010468|regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0031065|positive regulation of histone deacetylation;GO:0035886|vascular smooth muscle cell differentiation;GO:0035904|aorta development;GO:0043951|negative regulation of cAMP-mediated signaling;GO:0045766|positive regulation of angiogenesis;GO:0050878|regulation of body fluid levels;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;GO:0060183|apelin receptor signaling pathway;GO:0060412|ventricular septum morphogenesis;GO:0060841|venous blood vessel development;GO:0060976|coronary vasculature development;GO:1903589|positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:1903596|regulation of gap junction assembly;GO:1904325|positive regulation of inhibitory G protein-coupled receptor phosphorylation;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0042277|peptide binding;GO:0060182|apelin receptor activity;","K04174","APLNR; apelin receptor"]
["ENSRNOG00000022946",16,1.029287011,539,34.79884235,0.029578197,-5.079322082,{"v":3.4675e-127,"d":"3.47E-127"},{"v":2.5753e-126,"d":"2.58E-126"},"down","yes","Slc22a3","protein_coding","chr1:48235476-48324612:+","gi|9507117|ref|NP_062103.1|",2797,0,"solute carrier family 22 member 3 [Rattus norvegicus]","gi|9507116|ref|NM_019230.1|",3486,0,"Rattus norvegicus solute carrier family 22 member 3 (Slc22a3), mRNA","O88446",1082,0,"Solute carrier family 22 member 3",".",".",".",".","pfam00083","Sugar_tr","Sugar (and other) transporter.","GO:0006836|neurotransmitter transport;GO:0006837|serotonin transport;GO:0015695|organic cation transport;GO:0015697|quaternary ammonium group transport;GO:0015711|organic anion transport;GO:0015718|monocarboxylic acid transport;GO:0015844|monoamine transport;GO:0015850|organic hydroxy compound transport;GO:0015872|dopamine transport;GO:0032098|regulation of appetite;GO:0042908|xenobiotic transport;GO:0051608|histamine transport;GO:0051610|serotonin uptake;GO:0051615|histamine uptake;GO:0051620|norepinephrine uptake;GO:0051625|epinephrine uptake;GO:0055085|transmembrane transport;GO:0090494|dopamine uptake;GO:1901998|toxin transport;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0043025|neuronal cell body;GO:0098793|presynapse;","GO:0005326|neurotransmitter transporter activity;GO:0005330|dopamine:sodium symporter activity;GO:0005515|protein binding;GO:0008504|monoamine transmembrane transporter activity;GO:0008514|organic anion transmembrane transporter activity;GO:0015101|organic cation transmembrane transporter activity;GO:0015651|quaternary ammonium group transmembrane transporter activity;GO:0019534|toxin transmembrane transporter activity;GO:0022857|transmembrane transporter activity;","K08200","SLC22A3, OCT3; MFS transporter, OCT family, solute carrier family 22 (organic cation transporter), member 3"]
["ENSRNOG00000002776",12,0.771965258,530,34.21778562,0.022560351,-5.470066668,{"v":1.1071e-126,"d":"1.11E-126"},{"v":8.2012e-126,"d":"8.20E-126"},"down","yes","Sell","protein_coding","chr13:76416915-76436456:+","gi|94400781|ref|NP_062050.3|",1896,0,"L-selectin precursor [Rattus norvegicus]","gi|94400780|ref|NM_019177.3|",1187,0,"Rattus norvegicus selectin L (Sell), mRNA","P30836",729,0,"L-selectin",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0016339|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0033198|response to ATP;GO:0034201|response to oleic acid;GO:0042981|regulation of apoptotic process;GO:0050901|leukocyte tethering or rolling;GO:0055093|response to hyperoxia;GO:0070543|response to linoleic acid;GO:0090023|positive regulation of neutrophil chemotaxis;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;","GO:0002020|protease binding;GO:0005509|calcium ion binding;GO:0050839|cell adhesion molecule binding;GO:0051861|glycolipid binding;GO:0070492|oligosaccharide binding;","K06495","SELL, CD62L; selectin, lymphocyte"]
["ENSRNOG00000011683",387,24.89587958,1350,87.15851053,0.285639112,-1.807734555,{"v":2.006e-125,"d":"2.01E-125"},{"v":1.4802E-124,"d":"1.48E-124"},"down","yes","Fes","protein_coding","chr1:134337698-134346934:-","gi|157817059|ref|NP_001101958.1|",4046,0,"tyrosine-protein kinase Fes/Fps [Rattus norvegicus]","gi|157817058|ref|NM_001108488.1|",2461,0,"Rattus norvegicus FES proto-oncogene, tyrosine kinase (Fes), mRNA","P16879",1489,0,"Tyrosine-protein kinase Fes/Fps",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001578|microtubule bundle formation;GO:0006935|chemotaxis;GO:0007098|centrosome cycle;GO:0007155|cell adhesion;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0008360|regulation of cell shape;GO:0010976|positive regulation of neuron projection development;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0030154|cell differentiation;GO:0030155|regulation of cell adhesion;GO:0031116|positive regulation of microtubule polymerization;GO:0042127|regulation of cell proliferation;GO:0043304|regulation of mast cell degranulation;GO:0045087|innate immune response;GO:0045595|regulation of cell differentiation;GO:0045639|positive regulation of myeloid cell differentiation;GO:0045657|positive regulation of monocyte differentiation;GO:0046777|protein autophosphorylation;GO:0071305|cellular response to vitamin D;GO:2000145|regulation of cell motility;GO:2000251|positive regulation of actin cytoskeleton reorganization;","GO:0005737|cytoplasm;GO:0005925|focal adhesion;GO:0015630|microtubule cytoskeleton;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0031410|cytoplasmic vesicle;","GO:0004672|protein kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0005102|signaling receptor binding;GO:0005524|ATP binding;GO:0008017|microtubule binding;GO:0034987|immunoglobulin receptor binding;GO:0035091|phosphatidylinositol binding;","K07527","FES, FPS; tyrosine-protein kinase Fes/Fps [EC:2.7.10.2]"]
["ENSRNOG00000020035",134,8.620278717,837,54.03827653,0.159521718,-2.648175241,{"v":1.0213E-124,"d":"1.02E-124"},{"v":7.4877e-124,"d":"7.49E-124"},"down","yes","Cyp17a1","protein_coding","chr1:245535462-245541573:-","gi|564333876|ref|XP_006231496.1|",2594,0,"PREDICTED: steroid 17-alpha-hydroxylase/17,20 lyase isoform X1 [Rattus norvegicus]","gi|672040337|ref|XM_006231435.2|",1830,0,"PREDICTED: Rattus norvegicus cytochrome P450, family 17, subfamily a, polypeptide 1 (Cyp17a1), transcript variant X2, mRNA","P11715",983,0,"Steroid 17-alpha-hydroxylase/17,20 lyase","BH0579",116,{"v":6e-27,"d":"6.00E-27"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0006082|organic acid metabolic process;GO:0006694|steroid biosynthetic process;GO:0006702|androgen biosynthetic process;GO:0006704|glucocorticoid biosynthetic process;GO:0008202|steroid metabolic process;GO:0008584|male gonad development;GO:0009410|response to xenobiotic stimulus;GO:0009635|response to herbicide;GO:0009636|response to toxic substance;GO:0010033|response to organic substance;GO:0010034|response to acetate;GO:0010212|response to ionizing radiation;GO:0014070|response to organic cyclic compound;GO:0017085|response to insecticide;GO:0018879|biphenyl metabolic process;GO:0018894|dibenzo-p-dioxin metabolic process;GO:0018958|phenol-containing compound metabolic process;GO:0018963|phthalate metabolic process;GO:0021766|hippocampus development;GO:0030325|adrenal gland development;GO:0030728|ovulation;GO:0031667|response to nutrient levels;GO:0032526|response to retinoic acid;GO:0033327|Leydig cell differentiation;GO:0034097|response to cytokine;GO:0034698|response to gonadotropin;GO:0042446|hormone biosynthetic process;GO:0042448|progesterone metabolic process;GO:0048545|response to steroid hormone;GO:0051591|response to cAMP;GO:0051597|response to methylmercury;GO:0060992|response to fungicide;GO:0071222|cellular response to lipopolysaccharide;GO:0071236|cellular response to antibiotic;GO:0071371|cellular response to gonadotropin stimulus;GO:0090031|positive regulation of steroid hormone biosynthetic process;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016020|membrane;GO:0030424|axon;GO:0042995|cell projection;GO:0043025|neuronal cell body;GO:0043231|intracellular membrane-bounded organelle;","GO:0004508|steroid 17-alpha-monooxygenase activity;GO:0005506|iron ion binding;GO:0020037|heme binding;GO:0047442|17-alpha-hydroxyprogesterone aldolase activity;","K00512","CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase [EC:1.14.14.19 1.14.14.32]"]
["ENSRNOG00000063956",208,13.38073114,999,64.4972978,0.207461888,-2.269081769,{"v":1.2337e-124,"d":"1.23E-124"},{"v":9.0335e-124,"d":"9.03E-124"},"down","yes","Hoxc6","protein_coding","chr7:134135502-134148392:+","gi|511910465|ref|XP_004774628.1|",1102,{"v":3e-133,"d":"3.00E-133"},"PREDICTED: homeobox protein Hox-C6 isoform X1 [Mustela putorius furo]","gi|672060679|ref|XM_003750415.3|",10287,0,"PREDICTED: Rattus norvegicus homeo box C6 (Hoxc6), transcript variant X2, mRNA","P10629",429,{"v":1E-134,"d":"1.00E-134"},"Homeobox protein Hox-C6",".",".",".",".","pfam00046","Homeobox","Homeobox domain.",".",".",".",".","."]
["ENSRNOG00000020953",40,2.573217527,595,38.41430649,0.066985917,-3.899998383,{"v":1.3216E-124,"d":"1.32E-124"},{"v":9.6645e-124,"d":"9.66E-124"},"down","yes","Ms4a7","protein_coding","chr1:207968761-207983260:-","gi|157823009|ref|NP_001099808.1|",1150,{"v":6E-153,"d":"6.00E-153"},"membrane-spanning 4-domains subfamily A member 7 [Rattus norvegicus]","gi|448824828|ref|NM_001276398.1|",939,0,"Mus musculus membrane-spanning 4-domains, subfamily A, member 7 (Ms4a7), transcript variant 3, mRNA","Q9GZW8",196,{"v":7e-57,"d":"7.00E-57"},"Membrane-spanning 4-domains subfamily A member 7",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.",".","GO:0005802|trans-Golgi network;GO:0016021|integral component of membrane;",".","K22191","MS4A5_6_7; membrane-spanning 4-domains subfamily A member 5/6/7"]
["ENSRNOG00000021962",179,11.51514844,936,60.42990064,0.19055382,-2.391729562,{"v":2.4045e-124,"d":"2.40E-124"},{"v":1.7539E-123,"d":"1.75E-123"},"down","yes","Fzd2","protein_coding","chr10:87561326-87565334:+","gi|744583717|ref|XP_010984774.1|",2795,0,"PREDICTED: frizzled-2 [Camelus dromedarius]","gi|24394962|emb|AL672269.15|",3138,0,"Mouse DNA sequence from clone RP23-57F11 on chromosome 11, complete sequence","Q9JIP6",1083,0,"Frizzled-2",".",".",".",".","pfam01534","Frizzled","Frizzled/Smoothened family membrane region. This family contains the membrane spanning region of frizzled and smoothened receptors. This membrane region is predicted to contain seven transmembrane alpha helices. Proteins related to Drosophila frizzled are receptors for Wnt (mediating the beta-catenin signalling pathway), but also the planar cell polarity (PCP) pathway and the Wnt/calcium pathway. The predominantly alpha-helical Cys-rich ligand-binding region (CRD) of Frizzled is both necessary and sufficient for Wnt binding. The smoothened receptor mediates hedgehog signalling.","GO:0001775|cell activation;GO:0003149|membranous septum morphogenesis;GO:0003150|muscular septum morphogenesis;GO:0003151|outflow tract morphogenesis;GO:0007199|G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007223|Wnt signaling pathway, calcium modulating pathway;GO:0007267|cell-cell signaling;GO:0007608|sensory perception of smell;GO:0016055|Wnt signaling pathway;GO:0030855|epithelial cell differentiation;GO:0035567|non-canonical Wnt signaling pathway;GO:0045893|positive regulation of transcription, DNA-templated;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0060022|hard palate development;GO:0060070|canonical Wnt signaling pathway;GO:0060119|inner ear receptor cell development;GO:0060412|ventricular septum morphogenesis;GO:0071305|cellular response to vitamin D;GO:0071363|cellular response to growth factor stimulus;GO:0071375|cellular response to peptide hormone stimulus;GO:0090103|cochlea morphogenesis;GO:0090179|planar cell polarity pathway involved in neural tube closure;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0005515|protein binding;GO:0017147|Wnt-protein binding;GO:0030165|PDZ domain binding;GO:0042802|identical protein binding;GO:0042813|Wnt-activated receptor activity;GO:0046982|protein heterodimerization activity;","K02235","FZD2; frizzled 2"]
["ENSRNOG00000031814",389,25.02454045,1347,86.96482496,0.287754738,-1.79708841,{"v":3.7421E-124,"d":"3.74E-124"},{"v":2.726e-123,"d":"2.73E-123"},"down","yes","Sort1","protein_coding","chr2:195924099-196002354:+","gi|564338484|ref|XP_006233258.1|",4145,0,"PREDICTED: sortilin isoform X3 [Rattus norvegicus]","gi|672043859|ref|XM_006233196.2|",6942,0,"PREDICTED: Rattus norvegicus sortilin 1 (Sort1), transcript variant X3, mRNA","O54861",1538,0,"Sortilin",".",".",".",".","pfam12852","Cupin_6","Cupin. This is a family of bacterial and eukaryotic proteins that belong to the Cupin superfamily. Some of the proteins in this family are annotated as being members of the AraC family of transcription factors, in which case this domain corresponds to the ligand binding domain.","GO:0001503|ossification;GO:0006622|protein targeting to lysosome;GO:0006886|intracellular protein transport;GO:0006892|post-Golgi vesicle-mediated transport;GO:0006895|Golgi to endosome transport;GO:0006897|endocytosis;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007218|neuropeptide signaling pathway;GO:0008333|endosome to lysosome transport;GO:0008625|extrinsic apoptotic signaling pathway via death domain receptors;GO:0010468|regulation of gene expression;GO:0014902|myotube differentiation;GO:0016050|vesicle organization;GO:0032509|endosome transport via multivesicular body sorting pathway;GO:0032868|response to insulin;GO:0038180|nerve growth factor signaling pathway;GO:0045599|negative regulation of fat cell differentiation;GO:0046323|glucose import;GO:0048011|neurotrophin TRK receptor signaling pathway;GO:0048227|plasma membrane to endosome transport;GO:0051005|negative regulation of lipoprotein lipase activity;GO:0090160|Golgi to lysosome transport;GO:1904037|positive regulation of epithelial cell apoptotic process;","GO:0005764|lysosome;GO:0005765|lysosomal membrane;GO:0005769|early endosome;GO:0005789|endoplasmic reticulum membrane;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005905|clathrin-coated pit;GO:0009986|cell surface;GO:0010008|endosome membrane;GO:0016021|integral component of membrane;GO:0030136|clathrin-coated vesicle;GO:0030140|trans-Golgi network transport vesicle;GO:0030425|dendrite;GO:0030659|cytoplasmic vesicle membrane;GO:0031410|cytoplasmic vesicle;GO:0031965|nuclear membrane;GO:0032580|Golgi cisterna membrane;GO:0043025|neuronal cell body;GO:0043231|intracellular membrane-bounded organelle;GO:0048471|perinuclear region of cytoplasm;","GO:0010465|nerve growth factor receptor activity;GO:0016492|G protein-coupled neurotensin receptor activity;GO:0019899|enzyme binding;GO:0030379|neurotensin receptor activity, non-G protein-coupled;GO:0048406|nerve growth factor binding;GO:1905394|retromer complex binding;","K12388","SORT1; sortilin"]
["ENSRNOG00000011300",66,4.24580892,665,42.93363667,0.098892366,-3.33799703,{"v":5.726e-124,"d":"5.73E-124"},{"v":4.166e-123,"d":"4.17E-123"},"down","yes","Lama3","protein_coding","chr18:3523133-3751353:+","gi|392334060|ref|XP_003753074.1|",17693,0,"PREDICTED: laminin subunit alpha-3 isoform X2 [Rattus norvegicus]","gi|672030464|ref|XM_003753026.3|",10161,0,"PREDICTED: Rattus norvegicus laminin, alpha 3 (Lama3), transcript variant X2, mRNA","Q61789",6198,0,"Laminin subunit alpha-3",".",".",".",".","pfam06008","Laminin_I","Laminin Domain I. coiled-coil structure. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.","GO:0007155|cell adhesion;GO:0030155|regulation of cell adhesion;GO:0030334|regulation of cell migration;GO:0031581|hemidesmosome assembly;GO:0035987|endodermal cell differentiation;GO:0045995|regulation of embryonic development;GO:0098609|cell-cell adhesion;","GO:0005604|basement membrane;GO:0005608|laminin-3 complex;GO:0005610|laminin-5 complex;GO:0005783|endoplasmic reticulum;GO:0005912|adherens junction;GO:0016020|membrane;GO:0030056|hemidesmosome;","GO:0005102|signaling receptor binding;GO:0005515|protein binding;","K06240","LAMA3_5; laminin, alpha 3/5"]
["ENSRNOG00000029949",350,22.51565336,1274,82.2518092,0.273740524,-1.86911907,{"v":6.727e-124,"d":"6.73E-124"},{"v":4.888e-123,"d":"4.89E-123"},"down","yes","RGD1565462","protein_coding","chr6:123323629-123332433:+","gi|2507388|sp|P09006.3|SPA3N_RAT",2142,0,"RecName: Full=Serine protease inhibitor A3N; Short=Serpin A3N; AltName: Full=CPI-26; AltName: Full=Contrapsin-like protease inhibitor 6; AltName: Full=SPI-2.2; AltName: Full=Serine protease inhibitor 3; Short=SPI-3; Flags: Precursor","gi|298905524|emb|FQ209856.1|",3318,0,"Rattus norvegicus TL0ABA38YN22 mRNA sequence","P09006",826,0,"Serine protease inhibitor A3N","all0778",164,{"v":2e-42,"d":"2.00E-42"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0010951|negative regulation of endopeptidase activity;","GO:0005615|extracellular space;","GO:0004867|serine-type endopeptidase inhibitor activity;","K04525","SERPINA; serpin A"]
["ENSRNOG00000013328",1054,67.80428185,2424,156.4979478,0.433259878,-1.206695451,{"v":1.2703e-123,"d":"1.27E-123"},{"v":9.219e-123,"d":"9.22E-123"},"down","yes","Rbpms","protein_coding","chr16:58239474-58395426:+","gi|564389427|ref|XP_006253300.1|",1352,{"v":1E-179,"d":"1.00E-179"},"PREDICTED: RNA-binding protein with multiple splicing isoform X1 [Rattus norvegicus]","gi|672080331|ref|XM_006253238.2|",2292,0,"PREDICTED: Rattus norvegicus RNA binding protein with multiple splicing (Rbpms), transcript variant X1, mRNA","Q9WVB0",271,{"v":8e-84,"d":"8.00E-84"},"RNA-binding protein with multiple splicing",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0006979|response to oxidative stress;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0060391|positive regulation of SMAD protein signal transduction;","GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0010494|cytoplasmic stress granule;","GO:0003713|transcription coactivator activity;GO:0003723|RNA binding;GO:0003729|mRNA binding;GO:0008143|poly(A) binding;GO:0042803|protein homodimerization activity;","K25091","RBPMS; RNA-binding protein with multiple splicing"]
["ENSRNOG00000007823",30,1.929913146,557,35.96095583,0.053666903,-4.219823541,{"v":2.8429E-122,"d":"2.84E-122"},{"v":2.0475e-121,"d":"2.05E-121"},"down","yes","Hoxb6","protein_coding","chr10:81265056-81267449:+","gi|532051317|ref|XP_005368417.1|",855,{"v":8e-110,"d":"8.00E-110"},"PREDICTED: homeobox protein Hox-B6 [Microtus ochrogaster]","gi|672069229|ref|XM_006247232.2|",1304,0,"PREDICTED: Rattus norvegicus homeo box B6 (Hoxb6), transcript variant X2, mRNA","P09023",333,{"v":4e-111,"d":"4.00E-111"},"Homeobox protein Hox-B6",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0009952|anterior/posterior pattern specification;GO:0034101|erythrocyte homeostasis;GO:0048704|embryonic skeletal system morphogenesis;GO:0048706|embryonic skeletal system development;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837|sequence-specific double-stranded DNA binding;","K09306","HOX_6; homeobox protein HoxA/B/C6"]
["ENSRNOG00000020332",47,3.023530595,603,38.93080137,0.077664227,-3.68660596,{"v":1.4991e-121,"d":"1.50E-121"},{"v":1.0756E-120,"d":"1.08E-120"},"down","yes","Tnnt3","protein_coding","chr1:197652431-197669535:+","gi|149061720|gb|EDM12143.1|",662,{"v":1e-111,"d":"1.00E-111"},"troponin T3, skeletal, fast, isoform CRA_g, partial [Rattus norvegicus]","gi|33354295|gb|AC098563.6|",1277,0,"Rattus norvegicus 1 BAC CH230-123A15 (Children's Hospital Oakland Research Institute) complete sequence","P02641",269,{"v":5e-81,"d":"5.00E-81"},"Troponin T, fast skeletal muscle",".",".",".",".","pfam00992","Troponin","Troponin. Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). this Pfam contains members of the TnT subunit. Troponin is a complex of three proteins, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). The troponin complex regulates Ca++ induced muscle contraction. This family includes troponin T and troponin I. Troponin I binds to actin and troponin T binds to tropomyosin.","GO:0003009|skeletal muscle contraction;GO:0006936|muscle contraction;GO:0006937|regulation of muscle contraction;GO:0006942|regulation of striated muscle contraction;GO:0043462|regulation of ATPase activity;GO:0045214|sarcomere organization;GO:1903612|positive regulation of calcium-dependent ATPase activity;","GO:0005861|troponin complex;","GO:0003779|actin binding;GO:0005523|tropomyosin binding;GO:0030172|troponin C binding;GO:0031013|troponin I binding;GO:0031014|troponin T binding;GO:0048306|calcium-dependent protein binding;","K12046","TNNT3; troponin T, fast skeletal muscle"]
["ENSRNOG00000019555",1153,74.17299523,2553,164.8264277,0.45000669,-1.151981644,{"v":5.6094e-121,"d":"5.61E-121"},{"v":4.0096e-120,"d":"4.01E-120"},"down","yes","Arap1","protein_coding","chr1:155748652-155814184:+","gi|564298082|ref|XP_006223488.1|",6468,0,"PREDICTED: arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [Rattus norvegicus]","gi|672014084|ref|XM_006223426.2|",5169,0,"PREDICTED: Rattus norvegicus ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 (Arap1), transcript variant X2, mRNA","Q4LDD4",2307,0,"Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0001921|positive regulation of receptor recycling;GO:0007165|signal transduction;GO:0008360|regulation of cell shape;GO:0043547|positive regulation of GTPase activity;GO:0051270|regulation of cellular component movement;GO:0051491|positive regulation of filopodium assembly;GO:0051497|negative regulation of stress fiber assembly;","GO:0005654|nucleoplasm;GO:0005794|Golgi apparatus;GO:0005802|trans-Golgi network;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0031410|cytoplasmic vesicle;GO:0043231|intracellular membrane-bounded organelle;","GO:0005096|GTPase activator activity;GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;GO:0031702|type 1 angiotensin receptor binding;","K18439","ARAP1; Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1"]
["ENSRNOG00000049491",308,19.81377496,1179,76.11843253,0.260301931,-1.941742082,{"v":1.0189E-120,"d":"1.02E-120"},{"v":7.2466e-120,"d":"7.25E-120"},"down","yes","RT1-DMb","protein_coding","chr20:4693103-4700340:-","gi|258613997|ref|NP_942035.2|",1248,{"v":1E-168,"d":"1.00E-168"},"RT1 class II, DM beta precursor [Rattus norvegicus]","gi|672085842|ref|XM_003751925.3|",1292,0,"PREDICTED: Rattus norvegicus class II histocompatibility antigen, M beta 1 chain-like (LOC100909630), mRNA","P35737",421,{"v":6e-145,"d":"6.00E-145"},"Class II histocompatibility antigen, M beta 1 chain",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.","GO:0002250|adaptive immune response;GO:0002399|MHC class II protein complex assembly;GO:0002503|peptide antigen assembly with MHC class II protein complex;GO:0019882|antigen processing and presentation;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0042102|positive regulation of T cell proliferation;GO:0051085|chaperone cofactor-dependent protein refolding;GO:2001190|positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;","GO:0005764|lysosome;GO:0005765|lysosomal membrane;GO:0005770|late endosome;GO:0005771|multivesicular body;GO:0010008|endosome membrane;GO:0016021|integral component of membrane;GO:0031902|late endosome membrane;GO:0042613|MHC class II protein complex;GO:0043231|intracellular membrane-bounded organelle;","GO:0023026|MHC class II protein complex binding;","K06752","MHC2; MHC class II antigen"]
["ENSRNOG00000018659",171,11.00050493,901,58.17023555,0.189108826,-2.4027114,{"v":2.1095E-120,"d":"2.11E-120"},{"v":1.4967E-119,"d":"1.50E-119"},"down","yes","Csf1","protein_coding","chr2:195377215-195411704:-","gi|28201782|sp|Q8JZQ0.1|CSF1_RAT",2679,0,"RecName: Full=Macrophage colony-stimulating factor 1; Short=CSF-1; Short=MCSF; Contains: RecName: Full=Processed macrophage colony-stimulating factor 1; Flags: Precursor","gi|22255877|gb|AF515736.1|",2103,0,"Rattus norvegicus colony stimulating factor-1 (Csf1) mRNA, complete cds","Q8JZQ0",1037,0,"Macrophage colony-stimulating factor 1",".",".",".",".","pfam05337","CSF-1","Macrophage colony stimulating factor-1 (CSF-1). Colony stimulating factor 1 (CSF-1) is a homodimeric polypeptide growth factor whose primary function is to regulate the survival, proliferation, differentiation, and function of cells of the mononuclear phagocytic lineage. This lineage includes mononuclear phagocytic precursors, blood monocytes, tissue macrophages, osteoclasts, and microglia of the brain, all of which possess cell surface receptors for CSF-1. The protein has also been linked with male fertility and mutations in the Csf-1 gene have been found to cause osteopetrosis and failure of tooth eruption.","GO:0001503|ossification;GO:0001954|positive regulation of cell-matrix adhesion;GO:0002158|osteoclast proliferation;GO:0002931|response to ischemia;GO:0003006|developmental process involved in reproduction;GO:0006954|inflammatory response;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0008283|cell proliferation;GO:0008284|positive regulation of cell proliferation;GO:0010628|positive regulation of gene expression;GO:0010744|positive regulation of macrophage derived foam cell differentiation;GO:0010759|positive regulation of macrophage chemotaxis;GO:0030225|macrophage differentiation;GO:0030278|regulation of ossification;GO:0030316|osteoclast differentiation;GO:0030335|positive regulation of cell migration;GO:0032270|positive regulation of cellular protein metabolic process;GO:0032946|positive regulation of mononuclear cell proliferation;GO:0038145|macrophage colony-stimulating factor signaling pathway;GO:0040018|positive regulation of multicellular organism growth;GO:0042476|odontogenesis;GO:0042488|positive regulation of odontogenesis of dentin-containing tooth;GO:0045087|innate immune response;GO:0045651|positive regulation of macrophage differentiation;GO:0045657|positive regulation of monocyte differentiation;GO:0045672|positive regulation of osteoclast differentiation;GO:0045860|positive regulation of protein kinase activity;GO:0046579|positive regulation of Ras protein signal transduction;GO:0048873|homeostasis of number of cells within a tissue;GO:0060444|branching involved in mammary gland duct morphogenesis;GO:0060611|mammary gland fat development;GO:0060763|mammary duct terminal end bud growth;GO:0061518|microglial cell proliferation;GO:1901215|negative regulation of neuron death;GO:1902228|positive regulation of macrophage colony-stimulating factor signaling pathway;GO:1904141|positive regulation of microglial cell migration;GO:1905523|positive regulation of macrophage migration;","GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0016604|nuclear body;GO:0048471|perinuclear region of cytoplasm;GO:1990682|CSF1-CSF1R complex;","GO:0005125|cytokine activity;GO:0005157|macrophage colony-stimulating factor receptor binding;GO:0008083|growth factor activity;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;","K05453","CSF1, MCSF; macrophage colony-stimulating factor 1"]
["ENSRNOG00000000156",65,4.181478482,645,41.64239948,0.100413966,-3.315968157,{"v":1.2258E-119,"d":"1.23E-119"},{"v":8.6751e-119,"d":"8.68E-119"},"down","yes","Megf6","protein_coding","chr5:164738352-164839139:+","gi|12621134|ref|NP_075244.1|",7756,0,"multiple epidermal growth factor-like domains protein 6 precursor [Rattus norvegicus]","gi|12621133|ref|NM_022955.1|",5517,0,"Rattus norvegicus multiple EGF-like-domains 6 (Megf6), mRNA","O88281",2992,0,"Multiple epidermal growth factor-like domains protein 6",".",".",".",".","pfam07546","EMI","EMI domain. The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.",".","GO:0005576|extracellular region;","GO:0005509|calcium ion binding;","K24333","MEGF6; multiple epidermal growth factor-like domains protein 6"]
["ENSRNOG00000023546",886,56.99676823,2140,138.1623797,0.412534645,-1.277412812,{"v":2.0667e-119,"d":"2.07E-119"},{"v":1.4608E-118,"d":"1.46E-118"},"down","yes","Hspb1","protein_coding","chr12:20794028-20795743:-","gi|752993027|ref|NP_114176.4|",1071,{"v":1e-144,"d":"1.00E-144"},"heat shock protein beta-1 [Rattus norvegicus]","gi|752993026|ref|NM_031970.4|",876,0,"Rattus norvegicus heat shock protein family B (small) member 1 (Hspb1), mRNA","P42930",414,{"v":4e-145,"d":"4.00E-145"},"Heat shock protein beta-1",".",".",".",".","pfam00011","HSP20","Hsp20/alpha crystallin family.","GO:0001895|retina homeostasis;GO:0001932|regulation of protein phosphorylation;GO:0002931|response to ischemia;GO:0006469|negative regulation of protein kinase activity;GO:0007565|female pregnancy;GO:0007568|aging;GO:0009615|response to virus;GO:0010976|positive regulation of neuron projection development;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0035556|intracellular signal transduction;GO:0035924|cellular response to vascular endothelial growth factor stimulus;GO:0035994|response to muscle stretch;GO:0038033|positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway;GO:0043066|negative regulation of apoptotic process;GO:0043122|regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043536|positive regulation of blood vessel endothelial cell migration;GO:0045590|negative regulation of regulatory T cell differentiation;GO:0045766|positive regulation of angiogenesis;GO:0061077|chaperone-mediated protein folding;GO:0070301|cellular response to hydrogen peroxide;GO:0070527|platelet aggregation;GO:0071348|cellular response to interleukin-11;GO:0099641|anterograde axonal protein transport;GO:1902176|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;GO:1903202|negative regulation of oxidative stress-induced cell death;GO:1903545|cellular response to butyrate;GO:1990776|response to angiotensin;GO:2001028|positive regulation of endothelial cell chemotaxis;GO:2001234|negative regulation of apoptotic signaling pathway;","GO:0000502|proteasome complex;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005819|spindle;GO:0005886|plasma membrane;GO:0030018|Z disc;GO:0030424|axon;GO:0030425|dendrite;GO:0031430|M band;GO:0031674|I band;GO:0043204|perikaryon;GO:0043292|contractile fiber;GO:0045202|synapse;GO:0097512|cardiac myofibril;GO:0098839|postsynaptic density membrane;GO:1904115|axon cytoplasm;","GO:0005080|protein kinase C binding;GO:0005515|protein binding;GO:0008426|protein kinase C inhibitor activity;GO:0019901|protein kinase binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0043130|ubiquitin binding;GO:0044183|protein binding involved in protein folding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;","K04455","HSPB1; heat shock protein beta-1"]
["ENSRNOG00000054561",65,4.181478482,643,41.51327576,0.100726296,-3.311487734,{"v":3.8747E-119,"d":"3.87E-119"},{"v":2.7287e-118,"d":"2.73E-118"},"down","yes","Isg20","protein_coding","chr1:132815123-132837027:+","gi|157817035|ref|NP_001101957.1|",1202,{"v":6E-158,"d":"6.00E-158"},"apoptosis-enhancing nuclease [Rattus norvegicus]","gi|186910199|ref|NM_001108487.2|",1068,0,"Rattus norvegicus apoptosis enhancing nuclease (Aen), mRNA","B2GUW6",467,{"v":2E-159,"d":"2.00E-159"},"Apoptosis-enhancing nuclease","YOL080c",123,{"v":2e-30,"d":"2.00E-30"},"COG0847","pfam00929","RNase_T","Exonuclease. This family includes a variety of exonuclease proteins, such as ribonuclease T and the epsilon subunit of DNA polymerase III.;","GO:0000738|DNA catabolic process, exonucleolytic;GO:0006401|RNA catabolic process;GO:0009615|response to virus;GO:0045071|negative regulation of viral genome replication;GO:0051607|defense response to virus;GO:0090503|RNA phosphodiester bond hydrolysis, exonucleolytic;","GO:0005634|nucleus;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0015030|Cajal body;GO:0016605|PML body;","GO:0000175|3'-5'-exoribonuclease activity;GO:0004527|exonuclease activity;GO:0008310|single-stranded DNA 3'-5' exodeoxyribonuclease activity;GO:0030619|U1 snRNA binding;GO:0030620|U2 snRNA binding;GO:0034511|U3 snoRNA binding;","K12579","ISG20; interferon-stimulated gene 20 kDa protein [EC:3.1.13.1]"]
["ENSRNOG00000054274",270,17.36921831,1097,70.82436004,0.245243562,-2.027712833,{"v":6.3693e-119,"d":"6.37E-119"},{"v":4.4745e-118,"d":"4.47E-118"},"down","yes","Cacnb3","protein_coding","chr7:129783674-129797074:+","gi|625218776|ref|XP_007649531.1|",2550,0,"PREDICTED: voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [Cricetulus griseus]","gi|203221|gb|M88751.1|RATCACH3B",2388,0,"Rat calcium channel beta subunit-III mRNA, complete cds","P54287",938,0,"Voltage-dependent L-type calcium channel subunit beta-3",".",".",".",".","pfam00625","Guanylate_kin","Guanylate kinase.","GO:0006816|calcium ion transport;GO:0007268|chemical synaptic transmission;GO:0007528|neuromuscular junction development;GO:0050852|T cell receptor signaling pathway;GO:0050966|detection of mechanical stimulus involved in sensory perception of pain;GO:0060402|calcium ion transport into cytosol;GO:0061577|calcium ion transmembrane transport via high voltage-gated calcium channel;GO:0070588|calcium ion transmembrane transport;GO:0072659|protein localization to plasma membrane;GO:0090314|positive regulation of protein targeting to membrane;GO:0090650|cellular response to oxygen-glucose deprivation;GO:0098903|regulation of membrane repolarization during action potential;GO:1901385|regulation of voltage-gated calcium channel activity;GO:1901386|negative regulation of voltage-gated calcium channel activity;GO:1901387|positive regulation of voltage-gated calcium channel activity;GO:1901843|positive regulation of high voltage-gated calcium channel activity;GO:1902630|regulation of membrane hyperpolarization;GO:1905788|negative regulation of detection of mechanical stimulus involved in sensory perception of touch;GO:2000463|positive regulation of excitatory postsynaptic potential;","GO:0005737|cytoplasm;GO:0005891|voltage-gated calcium channel complex;GO:0016020|membrane;GO:0016324|apical plasma membrane;GO:0045202|synapse;GO:1990454|L-type voltage-gated calcium channel complex;","GO:0005245|voltage-gated calcium channel activity;GO:0005246|calcium channel regulator activity;GO:0005515|protein binding;GO:0008331|high voltage-gated calcium channel activity;GO:0019901|protein kinase binding;","K04864","CACNB3; voltage-dependent calcium channel beta-3"]
["ENSRNOG00000000697",893,57.4470813,2147,138.6143127,0.414438309,-1.27077073,{"v":7.6635e-119,"d":"7.66E-119"},{"v":5.3704e-118,"d":"5.37E-118"},"down","yes","Coro1c","protein_coding","chr12:42712991-42785179:+","gi|157818697|ref|NP_001102797.1|",2533,0,"coronin-1C [Rattus norvegicus]","gi|985482301|ref|NM_001109327.2|",1404,0,"Rattus norvegicus coronin 1C (Coro1c), mRNA","Q9WUM4",969,0,"Coronin-1C",".",".",".",".","pfam08954","DUF1900","Domain of unknown function (DUF1900). This domain is predominantly found in the structural protein coronin, and is duplicated in some sequences. It has no known function.","GO:0001755|neural crest cell migration;GO:0001932|regulation of protein phosphorylation;GO:0001933|negative regulation of protein phosphorylation;GO:0007015|actin filament organization;GO:0010632|regulation of epithelial cell migration;GO:0010633|negative regulation of epithelial cell migration;GO:0010762|regulation of fibroblast migration;GO:0016197|endosomal transport;GO:0016477|cell migration;GO:0044387|negative regulation of protein kinase activity by regulation of protein phosphorylation;GO:0045184|establishment of protein localization;GO:0051893|regulation of focal adhesion assembly;GO:0051895|negative regulation of focal adhesion assembly;GO:0090148|membrane fission;GO:0090630|activation of GTPase activity;GO:0097750|endosome membrane tubulation;GO:1900024|regulation of substrate adhesion-dependent cell spreading;GO:1900025|negative regulation of substrate adhesion-dependent cell spreading;GO:1900027|regulation of ruffle assembly;GO:2000394|positive regulation of lamellipodium morphogenesis;","GO:0005856|cytoskeleton;GO:0010008|endosome membrane;GO:0015629|actin cytoskeleton;GO:0016328|lateral plasma membrane;GO:0016600|flotillin complex;GO:0030027|lamellipodium;GO:0031982|vesicle;","GO:0031267|small GTPase binding;GO:0051015|actin filament binding;","K13886","CORO1B_1C_6; coronin-1B/1C/6"]
["ENSRNOG00000008180",654,42.07210657,1769,114.2099297,0.368375208,-1.440752127,{"v":1.1485E-118,"d":"1.15E-118"},{"v":8.0388e-118,"d":"8.04E-118"},"down","yes","Lyn","protein_coding","chr5:16639466-16756868:+","gi|674050187|ref|XP_008831300.1|",2796,0,"PREDICTED: tyrosine-protein kinase Lyn isoform X1 [Nannospalax galili]","gi|162287329|ref|NM_030857.2|",3430,0,"Rattus norvegicus LYN proto-oncogene, Src family tyrosine kinase (Lyn), transcript variant 1, mRNA","Q07014",1068,0,"Tyrosine-protein kinase Lyn",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001782|B cell homeostasis;GO:0001817|regulation of cytokine production;GO:0001933|negative regulation of protein phosphorylation;GO:0001934|positive regulation of protein phosphorylation;GO:0002250|adaptive immune response;GO:0002431|Fc receptor mediated stimulatory signaling pathway;GO:0002513|tolerance induction to self antigen;GO:0002553|histamine secretion by mast cell;GO:0002576|platelet degranulation;GO:0002762|negative regulation of myeloid leukocyte differentiation;GO:0002768|immune response-regulating cell surface receptor signaling pathway;GO:0002774|Fc receptor mediated inhibitory signaling pathway;GO:0002902|regulation of B cell apoptotic process;GO:0006468|protein phosphorylation;GO:0006974|cellular response to DNA damage stimulus;GO:0006991|response to sterol depletion;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0009410|response to xenobiotic stimulus;GO:0009636|response to toxic substance;GO:0009725|response to hormone;GO:0009743|response to carbohydrate;GO:0010976|positive regulation of neuron projection development;GO:0014003|oligodendrocyte development;GO:0014070|response to organic cyclic compound;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0030097|hemopoiesis;GO:0030154|cell differentiation;GO:0030218|erythrocyte differentiation;GO:0030335|positive regulation of cell migration;GO:0030889|negative regulation of B cell proliferation;GO:0031175|neuron projection development;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0031668|cellular response to extracellular stimulus;GO:0032868|response to insulin;GO:0033003|regulation of mast cell activation;GO:0033628|regulation of cell adhesion mediated by integrin;GO:0034136|negative regulation of toll-like receptor 2 signaling pathway;GO:0034142|toll-like receptor 4 signaling pathway;GO:0034144|negative regulation of toll-like receptor 4 signaling pathway;GO:0034605|cellular response to heat;GO:0035556|intracellular signal transduction;GO:0042327|positive regulation of phosphorylation;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0043200|response to amino acid;GO:0043304|regulation of mast cell degranulation;GO:0043407|negative regulation of MAP kinase activity;GO:0043434|response to peptide hormone;GO:0043552|positive regulation of phosphatidylinositol 3-kinase activity;GO:0045087|innate immune response;GO:0045646|regulation of erythrocyte differentiation;GO:0046777|protein autophosphorylation;GO:0048678|response to axon injury;GO:0050727|regulation of inflammatory response;GO:0050853|B cell receptor signaling pathway;GO:0050855|regulation of B cell receptor signaling pathway;GO:0051272|positive regulation of cellular component movement;GO:0051279|regulation of release of sequestered calcium ion into cytosol;GO:0060252|positive regulation of glial cell proliferation;GO:0060369|positive regulation of Fc receptor mediated stimulatory signaling pathway;GO:0070304|positive regulation of stress-activated protein kinase signaling cascade;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0070447|positive regulation of oligodendrocyte progenitor proliferation;GO:0070667|negative regulation of mast cell proliferation;GO:0070668|positive regulation of mast cell proliferation;GO:0071300|cellular response to retinoic acid;GO:0090025|regulation of monocyte chemotaxis;GO:0090330|regulation of platelet aggregation;GO:0097028|dendritic cell differentiation;GO:1902532|negative regulation of intracellular signal transduction;GO:1902961|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process;GO:2000670|positive regulation of dendritic cell apoptotic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005758|mitochondrial intermembrane space;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005912|adherens junction;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0030061|mitochondrial crista;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0031966|mitochondrial membrane;GO:0032991|protein-containing complex;GO:0034666|integrin alpha2-beta1 complex;GO:0043231|intracellular membrane-bounded organelle;GO:0045121|membrane raft;GO:0048471|perinuclear region of cytoplasm;GO:0098978|glutamatergic synapse;GO:0099091|postsynaptic specialization, intracellular component;","GO:0004672|protein kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0005102|signaling receptor binding;GO:0005161|platelet-derived growth factor receptor binding;GO:0005178|integrin binding;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0016301|kinase activity;GO:0017124|SH3 domain binding;GO:0019899|enzyme binding;GO:0031625|ubiquitin protein ligase binding;GO:0043015|gamma-tubulin binding;GO:0043208|glycosphingolipid binding;GO:0044325|ion channel binding;GO:0044877|protein-containing complex binding;GO:0046875|ephrin receptor binding;GO:0051219|phosphoprotein binding;GO:0097110|scaffold protein binding;GO:0140031|phosphorylation-dependent protein binding;","K05854","LYN; tyrosine-protein kinase Lyn [EC:2.7.10.2]"]
["ENSRNOG00000060329",368,23.67360125,1279,82.5746185,0.286693438,-1.802419212,{"v":1.8503E-118,"d":"1.85E-118"},{"v":1.2935E-117,"d":"1.29E-117"},"down","yes","Emb","protein_coding","chr2:49069087-49125050:+","gi|16758534|ref|NP_446171.1|",1432,0,"embigin precursor [Rattus norvegicus]","gi|298908415|emb|FQ228768.1|",977,0,"Rattus norvegicus TL0ADA51YP06 mRNA sequence","O88775",556,0,"Embigin",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0007155|cell adhesion;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007411|axon guidance;GO:0035879|plasma membrane lactate transport;GO:0070593|dendrite self-avoidance;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0045202|synapse;","GO:0005515|protein binding;GO:0098632|cell-cell adhesion mediator activity;",".","."]
["ENSRNOG00000029911",317,20.3927489,1183,76.37667997,0.267002296,-1.905075948,{"v":3.9417e-118,"d":"3.94E-118"},{"v":2.7521E-117,"d":"2.75E-117"},"down","yes","Cilp","protein_coding","chr8:65777281-65792251:+","gi|157823195|ref|NP_001101631.1|",6226,0,"cartilage intermediate layer protein 1 precursor [Rattus norvegicus]","gi|157823194|ref|NM_001108161.1|",4131,0,"Rattus norvegicus cartilage intermediate layer protein (Cilp), mRNA","Q66K08",2311,0,"Cartilage intermediate layer protein 1",".",".",".",".","pfam13330","Mucin2_WxxW","Mucin-2 protein WxxW repeating region. This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in a member from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.","GO:0008150|biological_process;GO:0010629|negative regulation of gene expression;GO:0043569|negative regulation of insulin-like growth factor receptor signaling pathway;GO:0060392|negative regulation of SMAD protein signal transduction;GO:0071560|cellular response to transforming growth factor beta stimulus;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0062023|collagen-containing extracellular matrix;","GO:0003674|molecular_function;GO:0030246|carbohydrate binding;","K24436","CILP; cartilage intermediate layer protein"]
["ENSRNOG00000038881",132,8.49161784,804,51.90773516,0.163590606,-2.611838191,{"v":4.0577e-118,"d":"4.06E-118"},{"v":2.8296E-117,"d":"2.83E-117"},"down","yes","Hcls1","protein_coding","chr11:63817476-63841014:-","gi|58865374|ref|NP_001011898.1|",1858,0,"hematopoietic lineage cell-specific protein [Rattus norvegicus]","gi|58865373|ref|NM_001011898.1|",1914,0,"Rattus norvegicus hematopoietic cell specific Lyn substrate 1 (Hcls1), mRNA","P49710",675,0,"Hematopoietic lineage cell-specific protein",".",".",".",".","pfam02218","HS1_rep","Repeat in HS1/Cortactin. The function of this repeat is unknown. Seven copies are found in cortactin and four copies are found in HS1. The repeats are always found amino terminal to an SH3 domain pfam00018.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0008284|positive regulation of cell proliferation;GO:0009725|response to hormone;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0030041|actin filament polymerization;GO:0030218|erythrocyte differentiation;GO:0030833|regulation of actin filament polymerization;GO:0030854|positive regulation of granulocyte differentiation;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0042307|positive regulation of protein import into nucleus;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0045651|positive regulation of macrophage differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051897|positive regulation of protein kinase B signaling;GO:0071345|cellular response to cytokine stimulus;GO:2000107|negative regulation of leukocyte apoptotic process;","GO:0005634|nucleus;GO:0005667|transcription factor complex;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0030427|site of polarized growth;GO:0030864|cortical actin cytoskeleton;","GO:0017124|SH3 domain binding;GO:0019901|protein kinase binding;GO:0044877|protein-containing complex binding;GO:0051015|actin filament binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;","K06106","CTTN, EMS1; cortactin"]
["ENSRNOG00000008862",35,2.251565336,555,35.83183211,0.062837014,-3.992241564,{"v":4.5854E-118,"d":"4.59E-118"},{"v":3.1938E-117,"d":"3.19E-117"},"down","yes","Abcg4","protein_coding","chr8:44611187-44626881:-","gi|148693626|gb|EDL25573.1|",3199,0,"mCG141862, isoform CRA_c, partial [Mus musculus]","gi|672061613|ref|XM_006242915.2|",3882,0,"PREDICTED: Rattus norvegicus ATP-binding cassette, subfamily G (WHITE), member 4 (Abcg4), transcript variant X1, mRNA","Q9H172",1134,0,"ATP-binding cassette sub-family G member 4","ECU03g0390_1",174,{"v":8e-47,"d":"8.00E-47"},"COG1131","pfam01061","ABC2_membrane","ABC-2 type transporter.","GO:0015918|sterol transport;GO:0033344|cholesterol efflux;GO:0042632|cholesterol homeostasis;GO:0055085|transmembrane transport;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0005886|plasma membrane;GO:0010008|endosome membrane;GO:0016021|integral component of membrane;GO:0031410|cytoplasmic vesicle;","GO:0005524|ATP binding;GO:0034041|sterol-transporting ATPase activity;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0046982|protein heterodimerization activity;","K05680","ABCG4; ATP-binding cassette, subfamily G (WHITE), member 4"]
["ENSRNOG00000001739",0,0.032165219,775,50.03544123,0.000642849,-10.60323312,{"v":1.2292E-117,"d":"1.23E-117"},{"v":8.5511E-117,"d":"8.55E-117"},"down","yes","Meltf","protein_coding","chr11:68884446-68906300:-","gi|157786780|ref|NP_001099342.1|",3312,0,"melanotransferrin precursor [Rattus norvegicus]","gi|157786779|ref|NM_001105872.1|",3774,0,"Rattus norvegicus melanotransferrin (Meltf), mRNA","Q9R0R1",1240,0,"Melanotransferrin",".",".",".",".","pfam00405","Transferrin","Transferrin.","GO:0006826|iron ion transport;GO:0010756|positive regulation of plasminogen activation;GO:0090091|positive regulation of extracellular matrix disassembly;GO:1900025|negative regulation of substrate adhesion-dependent cell spreading;","GO:0005615|extracellular space;GO:0005769|early endosome;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0046658|anchored component of plasma membrane;GO:0055037|recycling endosome;","GO:0005506|iron ion binding;","K06569","MFI2, CD228; melanoma-associated antigen p97"]
["ENSRNOG00000059903",130,8.362956964,795,51.32667843,0.162935869,-2.617623856,{"v":4.2674e-117,"d":"4.27E-117"},{"v":2.9614E-116,"d":"2.96E-116"},"down","yes","Thbs3","protein_coding","chr2:174621812-174633594:+","gi|768711606|ref|NP_001292387.1|",4504,0,"thrombospondin 3 precursor [Rattus norvegicus]","gi|768711605|ref|NM_001305458.1|",3155,0,"Rattus norvegicus thrombospondin 3 (Thbs3), mRNA","Q05895",1706,0,"Thrombospondin-3",".",".",".",".","pfam05735","TSP_C","Thrombospondin C-terminal region. This region is found at the C-terminus of thrombospondin and related proteins.","GO:0003417|growth plate cartilage development;GO:0007155|cell adhesion;GO:0043931|ossification involved in bone maturation;GO:0060346|bone trabecula formation;","GO:0005576|extracellular region;GO:0048471|perinuclear region of cytoplasm;","GO:0005509|calcium ion binding;GO:0008201|heparin binding;","K04659","THBS2S; thrombospondin 2/3/4/5"]
["ENSRNOG00000033372",771,49.59876784,1945,125.572817,0.394980132,-1.340148009,{"v":6.3511e-117,"d":"6.35E-117"},{"v":4.3967e-116,"d":"4.40E-116"},"down","yes","Klhl24","protein_coding","chr11:80846755-80877636:-","gi|26381170|dbj|BAB29759.2|",3257,0,"unnamed protein product [Mus musculus]","gi|62461584|ref|NM_181473.2|",4524,0,"Rattus norvegicus kelch-like family member 24 (Klhl24), mRNA","Q56A24",1219,0,"Kelch-like protein 24",".",".",".",".","pfam07707","BACK","BTB And C-terminal Kelch. This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).","GO:0016567|protein ubiquitination;GO:0045109|intermediate filament organization;GO:0051865|protein autoubiquitination;GO:2000312|regulation of kainate selective glutamate receptor activity;","GO:0005737|cytoplasm;GO:0005912|adherens junction;GO:0030057|desmosome;GO:0030424|axon;GO:0031463|Cul3-RING ubiquitin ligase complex;GO:0043204|perikaryon;",".","K10461","KLHL24_35; kelch-like protein 24/35"]
["ENSRNOG00000018509",19,1.222278326,505,32.60373913,0.0374889,-4.737392684,{"v":7.2745e-117,"d":"7.27E-117"},{"v":5.0299e-116,"d":"5.03E-116"},"down","yes","Cx3cr1","protein_coding","chr8:119782595-119800014:-","gi|19424190|ref|NP_598218.1|",1527,0,"CX3C chemokine receptor 1 [Rattus norvegicus]","gi|672063562|ref|XM_008766668.1|",3337,0,"PREDICTED: Rattus norvegicus chemokine (C-X3-C motif) receptor 1 (Cx3cr1), transcript variant X1, mRNA","P35411",592,0,"CX3C chemokine receptor 1",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001774|microglial cell activation;GO:0002052|positive regulation of neuroblast proliferation;GO:0002250|adaptive immune response;GO:0002282|microglial cell activation involved in immune response;GO:0002881|negative regulation of chronic inflammatory response to non-antigenic stimulus;GO:0002931|response to ischemia;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007155|cell adhesion;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007420|brain development;GO:0007613|memory;GO:0016525|negative regulation of angiogenesis;GO:0019221|cytokine-mediated signaling pathway;GO:0019722|calcium-mediated signaling;GO:0021626|central nervous system maturation;GO:0021795|cerebral cortex cell migration;GO:0030336|negative regulation of cell migration;GO:0030595|leukocyte chemotaxis;GO:0032680|regulation of tumor necrosis factor production;GO:0032691|negative regulation of interleukin-1 beta production;GO:0035176|social behavior;GO:0035425|autocrine signaling;GO:0045428|regulation of nitric oxide biosynthetic process;GO:0045766|positive regulation of angiogenesis;GO:0048246|macrophage chemotaxis;GO:0048874|host-mediated regulation of intestinal microbiota composition;GO:0050769|positive regulation of neurogenesis;GO:0050804|modulation of chemical synaptic transmission;GO:0050901|leukocyte tethering or rolling;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051897|positive regulation of protein kinase B signaling;GO:0060074|synapse maturation;GO:0060326|cell chemotaxis;GO:0061760|antifungal innate immune response;GO:0070098|chemokine-mediated signaling pathway;GO:0071222|cellular response to lipopolysaccharide;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0090026|positive regulation of monocyte chemotaxis;GO:0098883|synapse pruning;GO:0110091|negative regulation of hippocampal neuron apoptotic process;GO:0150090|multiple spine synapse organization, single dendrite;GO:1900272|negative regulation of long-term synaptic potentiation;GO:1903721|positive regulation of I-kappaB phosphorylation;GO:1904141|positive regulation of microglial cell migration;GO:1904150|negative regulation of microglial cell mediated cytotoxicity;GO:2001234|negative regulation of apoptotic signaling pathway;GO:2001240|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0032809|neuronal cell body membrane;GO:0043005|neuron projection;GO:0048471|perinuclear region of cytoplasm;GO:0097447|dendritic tree;","GO:0004896|cytokine receptor activity;GO:0004930|G protein-coupled receptor activity;GO:0004950|chemokine receptor activity;GO:0016493|C-C chemokine receptor activity;GO:0016495|C-X3-C chemokine receptor activity;GO:0019957|C-C chemokine binding;GO:0019960|C-X3-C chemokine binding;GO:0031737|CX3C chemokine receptor binding;","K04192","CX3CR1; CX3C chemokine receptor 1"]
["ENSRNOG00000063618",9,0.578973944,485,31.31250193,0.018490185,-5.757096555,{"v":2.0486e-116,"d":"2.05E-116"},{"v":1.4148E-115,"d":"1.41E-115"},"down","yes","Cxcr2","protein_coding","chr9:75729115-75739425:+","gi|8393600|ref|NP_058879.1|",1890,0,"C-X-C chemokine receptor type 2 [Rattus norvegicus]","gi|672065525|ref|XM_008767214.1|",2176,0,"PREDICTED: Rattus norvegicus chemokine (C-X-C motif) receptor 2 (Cxcr2), transcript variant X2, mRNA","P35407",732,0,"C-X-C chemokine receptor type 2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.",".",".",".",".","."]
["ENSRNOG00000007281",859,55.2598464,2078,134.1595444,0.411896497,-1.279646237,{"v":2.5553e-116,"d":"2.56E-116"},{"v":1.7605e-115,"d":"1.76E-115"},"down","yes","Flnc","protein_coding","chr4:58034189-58061844:+","gi|300797978|ref|NP_001178791.1|",14000,0,"filamin-C [Rattus norvegicus]","gi|300797977|ref|NM_001191862.1|",9011,0,"Rattus norvegicus filamin C (Flnc), mRNA","D3ZHA0",5395,0,"Filamin-C","ECU09g0290",140,{"v":4e-33,"d":"4.00E-33"},"COG5069","pfam00630","Filamin","Filamin/ABP280 repeat.","GO:0030036|actin cytoskeleton organization;GO:0055001|muscle cell development;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0016528|sarcoplasm;GO:0030018|Z disc;GO:0042383|sarcolemma;GO:0043034|costamere;","GO:0008092|cytoskeletal protein binding;GO:0030506|ankyrin binding;GO:0042802|identical protein binding;GO:0051015|actin filament binding;","K04437","FLNA; filamin"]
["ENSRNOG00000022669",1,0.064330438,633,40.86765716,1.574116E-3,-9.311242309,{"v":5.6775e-116,"d":"5.68E-116"},{"v":3.902e-115,"d":"3.90E-115"},"down","yes","Cd177","protein_coding","chr1:80340034-80360621:-","gi|564326863|ref|XP_006228609.1|",5129,0,"PREDICTED: CD177 antigen isoform X1 [Rattus norvegicus]","gi|672035169|ref|XM_006228547.2|",3264,0,"PREDICTED: Rattus norvegicus CD177 molecule (Cd177), transcript variant X1, mRNA","Q8R2S8",994,0,"CD177 antigen",".",".",".",".","pfam00021","UPAR_LY6","u-PAR/Ly-6 domain. This extracellular disulphide bond rich domain is related to pfam00087.","GO:0007155|cell adhesion;GO:0007159|leukocyte cell-cell adhesion;GO:0030100|regulation of endocytosis;GO:0032930|positive regulation of superoxide anion generation;GO:0034394|protein localization to cell surface;GO:0043315|positive regulation of neutrophil degranulation;GO:0045217|cell-cell junction maintenance;GO:0072672|neutrophil extravasation;GO:0098742|cell-cell adhesion via plasma-membrane adhesion molecules;GO:1990266|neutrophil migration;GO:2001044|regulation of integrin-mediated signaling pathway;","GO:0005886|plasma membrane;GO:0030667|secretory granule membrane;GO:0044853|plasma membrane raft;GO:0046658|anchored component of plasma membrane;GO:0070821|tertiary granule membrane;","GO:0002020|protease binding;GO:0005178|integrin binding;GO:0048306|calcium-dependent protein binding;","K06552","CD177, PRV1; CD177 antigen"]
["ENSRNOG00000051952",1310,84.27287402,2745,177.2223048,0.475520698,-1.072419957,{"v":5.7749E-116,"d":"5.77E-116"},{"v":3.9642e-115,"d":"3.96E-115"},"down","yes","Tes","protein_coding","chr4:45365285-45403829:+","gi|86129590|ref|NP_001034433.1|",2264,0,"testin [Rattus norvegicus]","gi|85001733|gb|DQ339047.1|",1343,0,"Rattus norvegicus testis derived transcript mRNA, complete cds","Q2LAP6",876,0,"Testin",".",".",".",".","pfam06297","PET","PET Domain. This domain is suggested to be involved in protein-protein interactions. The family is found in conjunction with pfam00412.","GO:0008285|negative regulation of cell proliferation;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005925|focal adhesion;GO:0030054|cell junction;GO:0032991|protein-containing complex;","GO:0005515|protein binding;GO:0008270|zinc ion binding;","K24270","TES; testin"]
["ENSRNOG00000066399",480,30.87861033,1462,94.38943882,0.327140522,-1.61201762,{"v":9.5458e-116,"d":"9.55E-116"},{"v":6.5449e-115,"d":"6.54E-115"},"down","yes","ENSRNOG00000066399","lncRNA","chr1:246153662-246156548:-","gi|26349705|dbj|BAC38492.1|",251,{"v":4e-21,"d":"4.00E-21"},"unnamed protein product [Mus musculus]","gi|672040470|ref|XM_006231514.2|",2880,0,"PREDICTED: Rattus norvegicus SH3 and PX domains 2A (Sh3pxd2a), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam15483","DUF4641","Domain of unknown function (DUF4641). This family of proteins is found in eukaryotes. Proteins in this family are typically between 201 and 519 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000017325",1,0.064330438,631,40.73853344,0.001579105,-9.306676814,{"v":1.1117E-115,"d":"1.11E-115"},{"v":7.6131e-115,"d":"7.61E-115"},"down","yes","Cldn7","protein_coding","chr10:54689987-54692171:+","gi|77735344|ref|NP_113890.1|",1006,{"v":1e-133,"d":"1.00E-133"},"claudin-7 precursor [Rattus norvegicus]","gi|77735343|ref|NM_031702.1|",1108,0,"Rattus norvegicus claudin 7 (Cldn7), mRNA","Q9Z1L1",392,{"v":3e-135,"d":"3.00E-135"},"Claudin-7",".",".",".",".","pfam00822","PMP22_Claudin","PMP-22/EMP/MP20/Claudin family.","GO:0007155|cell adhesion;GO:0007162|negative regulation of cell adhesion;GO:0008284|positive regulation of cell proliferation;GO:0016338|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;GO:0031333|negative regulation of protein complex assembly;GO:0043066|negative regulation of apoptotic process;GO:0045471|response to ethanol;GO:0070830|bicellular tight junction assembly;GO:2000147|positive regulation of cell motility;","GO:0005886|plasma membrane;GO:0005923|bicellular tight junction;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016327|apicolateral plasma membrane;GO:0016328|lateral plasma membrane;","GO:0005198|structural molecule activity;GO:0019904|protein domain specific binding;GO:0042802|identical protein binding;GO:0050839|cell adhesion molecule binding;","K06087","CLDN; claudin"]
["ENSRNOG00000062480",29,1.865582707,528,34.0886619,0.054727367,-4.191593744,{"v":1.3538e-115,"d":"1.35E-115"},{"v":9.2596e-115,"d":"9.26E-115"},"down","yes","ENSRNOG00000062480","protein_coding","chr1:69429269-69447438:+","gi|672013100|ref|XP_008772637.1|",1643,0,"PREDICTED: leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X1 [Rattus norvegicus]","gi|672013099|ref|XM_008774415.1|",1779,0,"PREDICTED: Rattus norvegicus leukocyte immunoglobulin-like receptor subfamily B member 4 (LOC103690369), transcript variant X1, mRNA","Q9HCN6",119,{"v":3E-28,"d":"3.00E-28"},"Platelet glycoprotein VI",".",".",".",".","pfam13927","Ig_3","Immunoglobulin domain. This family contains immunoglobulin-like domains.",".",".",".",".","."]
["ENSRNOG00000001476",6,0.385982629,486,31.37706379,0.012301426,-6.345030622,{"v":1.3661e-115,"d":"1.37E-115"},{"v":9.3328e-115,"d":"9.33E-115"},"down","yes","Cldn4","protein_coding","chr12:21751331-21753436:+","gi|58865612|ref|NP_001012022.1|",1035,{"v":1e-133,"d":"1.00E-133"},"claudin-4 [Rattus norvegicus]","gi|15799595|gb|AC091752.2|",2106,0,"Rattus norvegicus strain Brown Norway clone RP31-202M22, complete sequence","O35054",394,{"v":2E-131,"d":"2.00E-131"},"Claudin-4",".",".",".",".","pfam00822","PMP22_Claudin","PMP-22/EMP/MP20/Claudin family.","GO:0007155|cell adhesion;GO:0007565|female pregnancy;GO:0007623|circadian rhythm;GO:0015698|inorganic anion transport;GO:0022604|regulation of cell morphogenesis;GO:0030335|positive regulation of cell migration;GO:0032570|response to progesterone;GO:0061436|establishment of skin barrier;GO:0070293|renal absorption;GO:0070830|bicellular tight junction assembly;GO:0090303|positive regulation of wound healing;GO:1905050|positive regulation of metallopeptidase activity;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005911|cell-cell junction;GO:0005923|bicellular tight junction;GO:0009925|basal plasma membrane;GO:0016324|apical plasma membrane;GO:0016327|apicolateral plasma membrane;GO:0016328|lateral plasma membrane;GO:0070160|tight junction;","GO:0003674|molecular_function;GO:0005198|structural molecule activity;GO:0005254|chloride channel activity;","K06087","CLDN; claudin"]
["ENSRNOG00000010964",592,38.08361941,1649,106.4625066,0.357718606,-1.483102937,{"v":1.4696e-115,"d":"1.47E-115"},{"v":1.0028e-114,"d":"1.00E-114"},"down","yes","Akap13","protein_coding","chr1:129314402-129619646:+","gi|564328945|ref|XP_006229444.1|",12942,0,"PREDICTED: A-kinase anchor protein 13 isoform X1 [Rattus norvegicus]","gi|672037008|ref|XM_006229382.2|",8515,0,"PREDICTED: Rattus norvegicus A kinase (PRKA) anchor protein 13 (Akap13), transcript variant X1, mRNA","F1M3G7",4944,0,"A-kinase anchor protein 13","YLR371w",69.3,{"v":3E-10,"d":"3.00E-10"},"COG5422","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0006468|protein phosphorylation;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007507|heart development;GO:0035023|regulation of Rho protein signal transduction;GO:0035025|positive regulation of Rho protein signal transduction;GO:0035556|intracellular signal transduction;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043406|positive regulation of MAP kinase activity;GO:0051168|nuclear export;GO:0055007|cardiac muscle cell differentiation;GO:0060297|regulation of sarcomere organization;GO:0060348|bone development;GO:0061049|cell growth involved in cardiac muscle cell development;GO:0071875|adrenergic receptor signaling pathway;GO:0086023|adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process;GO:1900169|regulation of glucocorticoid mediated signaling pathway;","GO:0005634|nucleus;GO:0005829|cytosol;GO:0005884|actin filament;GO:0005938|cell cortex;GO:0015629|actin cytoskeleton;GO:0016020|membrane;GO:0030864|cortical actin cytoskeleton;GO:0048471|perinuclear region of cytoplasm;","GO:0004691|cAMP-dependent protein kinase activity;GO:0005078|MAP-kinase scaffold activity;GO:0005085|guanyl-nucleotide exchange factor activity;GO:0031267|small GTPase binding;GO:0046872|metal ion binding;GO:0051018|protein kinase A binding;GO:0060090|molecular adaptor activity;","K16529","ARHGEF13; A-kinase anchor protein 13"]
["ENSRNOG00000020699",102,6.561704695,722,46.61366267,0.140767842,-2.828610304,{"v":1.8912E-115,"d":"1.89E-115"},{"v":1.2889e-114,"d":"1.29E-114"},"down","yes","Cd37","protein_coding","chr1:95719190-95724648:-","gi|74212826|dbj|BAE33374.1|",923,{"v":3e-117,"d":"3.00E-117"},"unnamed protein product [Mus musculus]","gi|74212825|dbj|AK155663.1|",897,0,"Mus musculus B6-derived CD11 +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F730112L14 product:CD37 antigen, full insert sequence","P31053",348,{"v":1e-113,"d":"1.00E-113"},"Leukocyte antigen CD37",".",".",".",".","pfam00335","Tetraspannin","Tetraspanin family.","GO:0002639|positive regulation of immunoglobulin production;GO:0002920|regulation of humoral immune response;GO:0008285|negative regulation of cell proliferation;GO:0030886|negative regulation of myeloid dendritic cell activation;GO:0042832|defense response to protozoan;GO:0050688|regulation of defense response to virus;","GO:0001772|immunological synapse;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;",".","K06475","CD37, TSPAN26; CD37 antigen"]
["ENSRNOG00000061650",2,0.128660876,544,35.12165165,0.003663292,-8.092643461,{"v":7.1943e-115,"d":"7.19E-115"},{"v":4.8857e-114,"d":"4.89E-114"},"down","yes","Cdhr4","protein_coding","chr8:108682613-108690367:+","gi|564310622|ref|XP_006226624.1|",3767,0,"PREDICTED: cadherin-related family member 4 isoform X1 [Rattus norvegicus]","gi|672023327|ref|XM_006226562.2|",2686,0,"PREDICTED: Rattus norvegicus cadherin-related family member 4 (Cdhr4), transcript variant X1, mRNA","A6H8M9",975,0,"Cadherin-related family member 4",".",".",".",".","pfam00028","Cadherin","Cadherin domain.",".",".",".",".","."]
["ENSRNOG00000026203",39,2.508887089,554,35.76727025,0.070144774,-3.833520567,{"v":7.2344e-115,"d":"7.23E-115"},{"v":4.9071e-114,"d":"4.91E-114"},"down","yes","Pax8","protein_coding","chr3:7185723-7242363:-","gi|77020244|ref|NP_112403.2|",2032,0,"paired box protein Pax-8 [Rattus norvegicus]","gi|77020243|ref|NM_031141.2|",2484,0,"Rattus norvegicus paired box 8 (Pax8), mRNA","P51974",787,0,"Paired box protein Pax-8",".",".",".",".","pfam00292","PAX","'Paired box' domain.","GO:0001655|urogenital system development;GO:0001656|metanephros development;GO:0001658|branching involved in ureteric bud morphogenesis;GO:0001822|kidney development;GO:0001823|mesonephros development;GO:0003281|ventricular septum development;GO:0003337|mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0006351|transcription, DNA-templated;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006790|sulfur compound metabolic process;GO:0007417|central nervous system development;GO:0010667|negative regulation of cardiac muscle cell apoptotic process;GO:0030154|cell differentiation;GO:0030878|thyroid gland development;GO:0039003|pronephric field specification;GO:0042472|inner ear morphogenesis;GO:0042981|regulation of apoptotic process;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048793|pronephros development;GO:0048856|anatomical structure development;GO:0071371|cellular response to gonadotropin stimulus;GO:0071599|otic vesicle development;GO:0072050|S-shaped body morphogenesis;GO:0072073|kidney epithelium development;GO:0072108|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0072164|mesonephric tubule development;GO:0072207|metanephric epithelium development;GO:0072221|metanephric distal convoluted tubule development;GO:0072278|metanephric comma-shaped body morphogenesis;GO:0072284|metanephric S-shaped body morphogenesis;GO:0072289|metanephric nephron tubule formation;GO:0072305|negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis;GO:0072307|regulation of metanephric nephron tubule epithelial cell differentiation;GO:0090190|positive regulation of branching involved in ureteric bud morphogenesis;GO:1900212|negative regulation of mesenchymal cell apoptotic process involved in metanephros development;GO:1900215|negative regulation of apoptotic process involved in metanephric collecting duct development;GO:1900218|negative regulation of apoptotic process involved in metanephric nephron tubule development;GO:2000594|positive regulation of metanephric DCT cell differentiation;GO:2000611|positive regulation of thyroid hormone generation;GO:2000612|regulation of thyroid-stimulating hormone secretion;","GO:0005634|nucleus;GO:0005654|nucleoplasm;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0005515|protein binding;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09293","PAX8; paired box protein 8"]
["ENSRNOG00000018992",82,5.275095931,670,43.25644597,0.121949361,-3.0356459,{"v":7.3822e-115,"d":"7.38E-115"},{"v":5.0014e-114,"d":"5.00E-114"},"down","yes","Dpysl3","protein_coding","chr18:35377181-35480157:-","gi|564393310|ref|XP_006254732.1|",3480,0,"PREDICTED: dihydropyrimidinase-related protein 3 isoform X1 [Rattus norvegicus]","gi|612407884|ref|NM_001291455.1|",2292,0,"Mus musculus dihydropyrimidinase-like 3 (Dpysl3), transcript variant 3, mRNA","Q62952",1131,0,"Dihydropyrimidinase-related protein 3","PA0441",425,{"v":2E-137,"d":"2.00E-137"},"COG0044","pfam01979","Amidohydro_1","Amidohydrolase family. This family of enzymes are a a large metal dependent hydrolase superfamily. The family includes Adenine deaminase EC:3.5.4.2 that hydrolyses adenine to form hypoxanthine and ammonia. Adenine deaminases reaction is important for adenine utilisation as a purine and also as a nitrogen source. This family also includes dihydroorotase and N-acetylglucosamine-6-phosphate deacetylases, EC:3.5.1.25 These enzymes catalyse the reaction N-acetyl-D-glucosamine 6-phosphate + H2O <=> D-glucosamine 6-phosphate + acetate. This family includes the catalytic domain of urease alpha subunit. Dihydroorotases (EC:3.5.2.3) are also included.","GO:0007399|nervous system development;GO:0010976|positive regulation of neuron projection development;GO:0010977|negative regulation of neuron projection development;GO:0030336|negative regulation of cell migration;GO:0048666|neuron development;GO:0048678|response to axon injury;GO:0051017|actin filament bundle assembly;GO:0051491|positive regulation of filopodium assembly;GO:0051764|actin crosslink formation;GO:0071345|cellular response to cytokine stimulus;","GO:0005615|extracellular space;GO:0005829|cytosol;GO:0030027|lamellipodium;GO:0030426|growth cone;GO:0031941|filamentous actin;GO:0044297|cell body;GO:0045202|synapse;GO:0070382|exocytic vesicle;","GO:0017124|SH3 domain binding;GO:0031005|filamin binding;GO:0035374|chondroitin sulfate binding;GO:0042802|identical protein binding;GO:0051219|phosphoprotein binding;",".","."]
["ENSRNOG00000047367",45,2.894869718,569,36.73569814,0.078802632,-3.665612365,{"v":2.4272e-114,"d":"2.43E-114"},{"v":1.6425E-113,"d":"1.64E-113"},"down","yes","Card14","protein_coding","chr10:104566424-104601905:+","gi|564313819|ref|XP_006221025.1|",4658,0,"PREDICTED: caspase recruitment domain-containing protein 14 [Rattus norvegicus]","gi|568971961|ref|XM_006532373.1|",2855,0,"PREDICTED: Mus musculus caspase recruitment domain family, member 14 (Card14), transcript variant X8, mRNA","Q99KF0",1735,0,"Caspase recruitment domain-containing protein 14",".",".",".",".","pfam00619","CARD","Caspase recruitment domain. Motif contained in proteins involved in apoptotic signaling. Predicted to possess a DEATH (pfam00531) domain-like fold.","GO:0001934|positive regulation of protein phosphorylation;GO:0033209|tumor necrosis factor-mediated signaling pathway;GO:0043066|negative regulation of apoptotic process;GO:0051092|positive regulation of NF-kappaB transcription factor activity;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016235|aggresome;","GO:0050700|CARD domain binding;","K20913","CARD14; caspase recruitment domain-containing protein 14"]
["ENSRNOG00000019249",17,1.093617449,487,31.44162565,0.034782472,-4.84549574,{"v":1.2742E-113,"d":"1.27E-113"},{"v":8.5617e-113,"d":"8.56E-113"},"down","yes","Ap3b2","pseudogene","chr1:135412580-135445191:-","gi|392337767|ref|XP_003753350.1|",3501,0,"PREDICTED: AP-3 complex subunit beta-2 isoform X3 [Rattus norvegicus]","gi|672013933|ref|XM_003753302.3|",3620,0,"PREDICTED: Rattus norvegicus adaptor-related protein complex 3, beta 2 subunit (Ap3b2), transcript variant X3, mRNA","Q9JME5",1345,0,"AP-3 complex subunit beta-2","SPAC23H3.06",300,{"v":5e-86,"d":"5.00E-86"},"COG5096","pfam01602","Adaptin_N","Adaptin N terminal region. This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.","GO:0006886|intracellular protein transport;GO:0008089|anterograde axonal transport;GO:0016192|vesicle-mediated transport;GO:0048490|anterograde synaptic vesicle transport;","GO:0030123|AP-3 adaptor complex;GO:0030665|clathrin-coated vesicle membrane;GO:1904115|axon cytoplasm;",".","K12397","AP3B; AP-3 complex subunit beta"]
["ENSRNOG00000033772",1365,87.81104812,2803,180.9668926,0.485232668,-1.043251413,{"v":3.0151E-113,"d":"3.02E-113"},{"v":2.014e-112,"d":"2.01E-112"},"down","yes","Serpinb9","protein_coding","chr17:31420125-31443230:-","gi|56090431|ref|NP_001007733.1|",1687,0,"serpin B9 [Rattus norvegicus]","gi|672081611|ref|XM_006253872.2|",2087,0,"PREDICTED: Rattus norvegicus serpin peptidase inhibitor, clade B (ovalbumin), member 9 (Serpinb9), transcript variant X1, mRNA","P50453",454,{"v":5e-152,"d":"5.00E-152"},"Serpin B9","MA2246",155,{"v":1E-42,"d":"1.00E-42"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0001913|T cell mediated cytotoxicity;GO:0002438|acute inflammatory response to antigenic stimulus;GO:0002448|mast cell mediated immunity;GO:0006915|apoptotic process;GO:0006955|immune response;GO:0008150|biological_process;GO:0009617|response to bacterium;GO:0010628|positive regulation of gene expression;GO:0010951|negative regulation of endopeptidase activity;GO:0033668|negative regulation by symbiont of host apoptotic process;GO:0042270|protection from natural killer cell mediated cytotoxicity;GO:0042742|defense response to bacterium;GO:0043066|negative regulation of apoptotic process;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0070233|negative regulation of T cell apoptotic process;GO:0071391|cellular response to estrogen stimulus;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005829|cytosol;","GO:0002020|protease binding;GO:0003674|molecular_function;GO:0004867|serine-type endopeptidase inhibitor activity;GO:0043027|cysteine-type endopeptidase inhibitor activity involved in apoptotic process;","K13963","SERPINB; serpin B"]
["ENSRNOG00000017414",229,14.73167034,987,63.72255548,0.23118455,-2.112883106,{"v":6.7577e-113,"d":"6.76E-113"},{"v":4.5088e-112,"d":"4.51E-112"},"down","yes","Irf7","protein_coding","chr1:196367361-196370832:-","gi|76096318|ref|NP_001028863.1|",2147,0,"interferon regulatory factor 7 [Rattus norvegicus]","gi|564331708|ref|XM_006230540.1|",1989,0,"PREDICTED: Rattus norvegicus interferon regulatory factor 7 (Irf7), transcript variant X1, mRNA","P70434",696,0,"Interferon regulatory factor 7",".",".",".",".","pfam10401","IRF-3","Interferon-regulatory factor 3. This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1).  Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.","GO:0002376|immune system process;GO:0002819|regulation of adaptive immune response;GO:0006357|regulation of transcription by RNA polymerase II;GO:0010468|regulation of gene expression;GO:0016064|immunoglobulin mediated immune response;GO:0032481|positive regulation of type I interferon production;GO:0032727|positive regulation of interferon-alpha production;GO:0032728|positive regulation of interferon-beta production;GO:0034124|regulation of MyD88-dependent toll-like receptor signaling pathway;GO:0034127|regulation of MyD88-independent toll-like receptor signaling pathway;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051607|defense response to virus;GO:0060337|type I interferon signaling pathway;GO:0060340|positive regulation of type I interferon-mediated signaling pathway;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987|proximal promoter sequence-specific DNA binding;GO:0003677|DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09447","IRF7; interferon regulatory factor 7"]
["ENSRNOG00000001963",42,2.701878404,554,35.76727025,0.075540526,-3.726605363,{"v":1.1005e-112,"d":"1.10E-112"},{"v":7.3257e-112,"d":"7.33E-112"},"down","yes","Mx2","protein_coding","chr11:36906111-36930342:+","gi|71534283|ref|NP_599177.2|",3379,0,"interferon-induced GTP-binding protein Mx2 [Rattus norvegicus]","gi|56722|emb|X52712.1|",2150,0,"Rat mRNA for Mx2 protein","P18590",1302,0,"Interferon-induced GTP-binding protein Mx3","YKR001c",231,{"v":4e-64,"d":"4.00E-64"},"COG0699","pfam01031","Dynamin_M","Dynamin central region. This region lies between the GTPase domain, see pfam00350, and the pleckstrin homology (PH) domain, see pfam00169.","GO:0009615|response to virus;GO:0016197|endosomal transport;GO:0034340|response to type I interferon;GO:0035455|response to interferon-alpha;GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0046822|regulation of nucleocytoplasmic transport;GO:0051607|defense response to virus;GO:0051726|regulation of cell cycle;GO:0071357|cellular response to type I interferon;GO:1901253|negative regulation of intracellular transport of viral material;","GO:0005634|nucleus;GO:0005643|nuclear pore;GO:0005737|cytoplasm;GO:0005874|microtubule;GO:0016020|membrane;GO:0070382|exocytic vesicle;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0008017|microtubule binding;","K14754","MX; interferon-induced GTP-binding protein Mx"]
["ENSRNOG00000018394",36,2.315895775,536,34.60515678,0.06692343,-3.901344808,{"v":1.8058e-112,"d":"1.81E-112"},{"v":1.1992E-111,"d":"1.20E-111"},"down","yes","Chrdl2","protein_coding","chr1:154343201-154370640:+","gi|157820135|ref|NP_001101007.1|",2210,0,"chordin-like protein 2 precursor [Rattus norvegicus]","gi|157820134|ref|NM_001107537.1|",1529,0,"Rattus norvegicus chordin-like 2 (Chrdl2), mRNA","Q8VEA6",817,0,"Chordin-like protein 2",".",".",".",".","pfam00093","VWC","von Willebrand factor type C domain. The high cutoff was used to prevent overlap with pfam00094.","GO:0030154|cell differentiation;GO:0030514|negative regulation of BMP signaling pathway;",".",".","K17280","CHRDL2; chordin-like protein 2"]
["ENSRNOG00000056837",747,48.05483732,1876,121.1180487,0.396760333,-1.333660299,{"v":5.0711e-112,"d":"5.07E-112"},{"v":3.3483e-111,"d":"3.35E-111"},"down","yes","Abr","protein_coding","chr10:61262516-61461505:-","gi|880872505|ref|XP_012967158.1|",5509,0,"PREDICTED: active breakpoint cluster region-related protein isoform X1 [Mesocricetus auratus]","gi|747019235|ref|NM_001105814.2|",4864,0,"Rattus norvegicus active BCR-related (Abr), mRNA","Q5SSL4",1727,0,"Active breakpoint cluster region-related protein",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0002692|negative regulation of cellular extravasation;GO:0007420|brain development;GO:0030036|actin cytoskeleton organization;GO:0030336|negative regulation of cell migration;GO:0032496|response to lipopolysaccharide;GO:0035556|intracellular signal transduction;GO:0042472|inner ear morphogenesis;GO:0043114|regulation of vascular permeability;GO:0043314|negative regulation of neutrophil degranulation;GO:0043547|positive regulation of GTPase activity;GO:0050728|negative regulation of inflammatory response;GO:0050766|positive regulation of phagocytosis;GO:0050804|modulation of chemical synaptic transmission;GO:0050885|neuromuscular process controlling balance;GO:0060313|negative regulation of blood vessel remodeling;GO:0090630|activation of GTPase activity;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0030424|axon;GO:0043197|dendritic spine;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098978|glutamatergic synapse;GO:0099092|postsynaptic density, intracellular component;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0005096|GTPase activator activity;GO:0005515|protein binding;","K20629","ABR; active breakpoint cluster region-related protein"]
["ENSRNOG00000012172",140,9.006261346,794,51.26211657,0.175690392,-2.5088928,{"v":1.1819E-111,"d":"1.18E-111"},{"v":7.7857e-111,"d":"7.79E-111"},"down","yes","Spi1","protein_coding","chr3:77073012-77092393:+","gi|564341813|ref|XP_006234594.1|",1276,{"v":4e-169,"d":"4.00E-169"},"PREDICTED: transcription factor PU.1 isoform X1 [Rattus norvegicus]","gi|672046223|ref|XM_006234532.2|",2027,0,"PREDICTED: Rattus norvegicus Spi-1 proto-oncogene (Spi1), transcript variant X1, mRNA","Q6BDS1",489,{"v":5E-168,"d":"5.00E-168"},"Transcription factor PU.1",".",".",".",".","pfam00178","Ets","Ets-domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001944|vasculature development;GO:0002314|germinal center B cell differentiation;GO:0002316|follicular B cell differentiation;GO:0002320|lymphoid progenitor cell differentiation;GO:0002327|immature B cell differentiation;GO:0002357|defense response to tumor cell;GO:0002572|pro-T cell differentiation;GO:0002573|myeloid leukocyte differentiation;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0030098|lymphocyte differentiation;GO:0030154|cell differentiation;GO:0030218|erythrocyte differentiation;GO:0030225|macrophage differentiation;GO:0030851|granulocyte differentiation;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0035019|somatic stem cell population maintenance;GO:0036462|TRAIL-activated apoptotic signaling pathway;GO:0043011|myeloid dendritic cell differentiation;GO:0043314|negative regulation of neutrophil degranulation;GO:0043966|histone H3 acetylation;GO:0044027|hypermethylation of CpG island;GO:0045347|negative regulation of MHC class II biosynthetic process;GO:0045646|regulation of erythrocyte differentiation;GO:0045814|negative regulation of gene expression, epigenetic;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051090|regulation of DNA-binding transcription factor activity;GO:0060033|anatomical structure regression;GO:0070102|interleukin-6-mediated signaling pathway;GO:0071361|cellular response to ethanol;GO:0090241|negative regulation of histone H4 acetylation;GO:0090402|oncogene-induced cell senescence;GO:0098508|endothelial to hematopoietic transition;GO:0120186|negative regulation of protein localization to chromatin;GO:1900745|positive regulation of p38MAPK cascade;GO:1901223|negative regulation of NIK/NF-kappaB signaling;GO:1901674|regulation of histone H3-K27 acetylation;GO:1902262|apoptotic process involved in blood vessel morphogenesis;GO:1902895|positive regulation of pri-miRNA transcription by RNA polymerase II;GO:1904151|positive regulation of microglial cell mediated cytotoxicity;GO:1904178|negative regulation of adipose tissue development;GO:1904238|pericyte cell differentiation;GO:1905036|positive regulation of antifungal innate immune response;GO:1905453|regulation of myeloid progenitor cell differentiation;GO:2000529|positive regulation of myeloid dendritic cell chemotaxis;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987|proximal promoter sequence-specific DNA binding;GO:0001216|bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding;GO:0001217|bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003700|DNA-binding transcription factor activity;GO:0005515|protein binding;GO:0042826|histone deacetylase binding;GO:0043565|sequence-specific DNA binding;GO:0051525|NFAT protein binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;GO:0097677|STAT family protein binding;","K09438","SPI1; transcription factor PU.1"]
["ENSRNOG00000002997",740,47.60452426,1861,120.1496208,0.396210358,-1.335661499,{"v":2.1538e-111,"d":"2.15E-111"},{"v":1.4172e-110,"d":"1.42E-110"},"down","yes","Slc9a3r2","protein_coding","chr10:13662461-13673049:-","gi|148690402|gb|EDL22349.1|",1566,0,"solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 2, isoform CRA_b, partial [Mus musculus]","gi|158138512|ref|NM_053811.3|",2036,0,"Rattus norvegicus SLC9A3 regulator 2 (Slc9a3r2), mRNA","Q920G2",590,0,"Na(+)/H(+) exchange regulatory cofactor NHE-RF2",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.","GO:0007605|sensory perception of sound;GO:0014067|negative regulation of phosphatidylinositol 3-kinase signaling;GO:0034767|positive regulation of ion transmembrane transport;GO:0048839|inner ear development;GO:0072659|protein localization to plasma membrane;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0012505|endomembrane system;GO:0016324|apical plasma membrane;GO:0032420|stereocilium;GO:0032421|stereocilium bundle;GO:0032991|protein-containing complex;","GO:0005102|signaling receptor binding;GO:0005515|protein binding;GO:0008013|beta-catenin binding;GO:0008022|protein C-terminus binding;GO:0019902|phosphatase binding;GO:0042802|identical protein binding;GO:0043495|protein membrane anchor;GO:0047485|protein N-terminus binding;GO:0050750|low-density lipoprotein particle receptor binding;GO:0060090|molecular adaptor activity;","K13358","SLC9A3R2, NHERF2; sodium/hydrogen exchange regulatory cofactor NHE-RF2"]
["ENSRNOG00000001750",54,3.473843662,582,37.57500232,0.092450923,-3.43516846,{"v":2.6467e-111,"d":"2.65E-111"},{"v":1.7395e-110,"d":"1.74E-110"},"down","yes","Chrd","protein_coding","chr11:80171994-80180673:-","gi|564377433|ref|XP_006248619.1|",4395,0,"PREDICTED: chordin isoform X2 [Rattus norvegicus]","gi|672071537|ref|XM_006248557.2|",3312,0,"PREDICTED: Rattus norvegicus chordin (Chrd), transcript variant X2, mRNA","Q63148",1638,0,"Chordin",".",".",".",".","pfam07452","CHRD","CHRD domain. CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in chordin, an inhibitor of bone morphogenetic proteins. This family includes bacterial homologues. It is anticipated to have an immunoglobulin-like beta-barrel structure based on limited similarity to superoxide dismutases but, as yet, no clear functional prediction can be made. Its most conserved feature is a GE[I/L]RCG[V/I/L] motif towards its C-terminal end Most bacterial proteins in this family have only one CHRD domain, whereas it is found repeated in many eukaryotic proteins such as human chordin and Drosophila SOG..","GO:0001501|skeletal system development;GO:0001649|osteoblast differentiation;GO:0001702|gastrulation with mouth forming second;GO:0001707|mesoderm formation;GO:0002053|positive regulation of mesenchymal cell proliferation;GO:0007389|pattern specification process;GO:0007417|central nervous system development;GO:0009953|dorsal/ventral pattern formation;GO:0021919|BMP signaling pathway involved in spinal cord dorsal/ventral patterning;GO:0030336|negative regulation of cell migration;GO:0030514|negative regulation of BMP signaling pathway;GO:0030900|forebrain development;GO:0045668|negative regulation of osteoblast differentiation;GO:0045785|positive regulation of cell adhesion;","GO:0005615|extracellular space;","GO:0008201|heparin binding;GO:0045545|syndecan binding;","K04657","CHRD; chordin"]
["ENSRNOG00000032708",135,8.684609155,781,50.42281239,0.172235715,-2.53754376,{"v":3.0256e-111,"d":"3.03E-111"},{"v":1.9862E-110,"d":"1.99E-110"},"down","yes","RT1-Bb","protein_coding","chr20:4596559-4607597:-","gi|46237565|emb|CAE83945.1|",1143,{"v":1e-140,"d":"1.00E-140"},"RT1 class II, B beta [Rattus norvegicus]","gi|89214481|gb|AC120734.5|",4049,0,"Rattus norvegicus BAC CH230-220D1 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P29826",418,{"v":2E-132,"d":"2.00E-132"},"Rano class II histocompatibility antigen, B-1 beta chain",".",".",".",".","pfam00969","MHC_II_beta","Class II histocompatibility antigen, beta domain.","GO:0002250|adaptive immune response;GO:0002344|B cell affinity maturation;GO:0002381|immunoglobulin production involved in immunoglobulin mediated immune response;GO:0002503|peptide antigen assembly with MHC class II protein complex;GO:0002504|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;GO:0002579|positive regulation of antigen processing and presentation;GO:0002827|positive regulation of T-helper 1 type immune response;GO:0006955|immune response;GO:0006959|humoral immune response;GO:0019882|antigen processing and presentation;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0042130|negative regulation of T cell proliferation;GO:0046635|positive regulation of alpha-beta T cell activation;GO:0048002|antigen processing and presentation of peptide antigen;GO:0050832|defense response to fungus;GO:0050852|T cell receptor signaling pathway;GO:0050870|positive regulation of T cell activation;GO:0071315|cellular response to morphine;GO:0071346|cellular response to interferon-gamma;GO:0071385|cellular response to glucocorticoid stimulus;GO:0071549|cellular response to dexamethasone stimulus;","GO:0005769|early endosome;GO:0005771|multivesicular body;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0042613|MHC class II protein complex;","GO:0015643|toxic substance binding;GO:0023026|MHC class II protein complex binding;GO:0031625|ubiquitin protein ligase binding;GO:0042605|peptide antigen binding;GO:0044877|protein-containing complex binding;GO:1990405|protein antigen binding;","K06752","MHC2; MHC class II antigen"]
["ENSRNOG00000028619",48,3.087861033,565,36.47745071,0.084651229,-3.562325176,{"v":3.4209e-111,"d":"3.42E-111"},{"v":2.2406e-110,"d":"2.24E-110"},"down","yes","Hoxc8","protein_coding","chr7:134127913-134130503:+","gi|471366946|ref|XP_004374005.1|",1184,{"v":1e-159,"d":"1.00E-159"},"PREDICTED: homeobox protein Hox-C8 [Trichechus manatus latirostris]","gi|309319782|ref|NM_001177326.2|",1228,0,"Rattus norvegicus homeobox C8 (Hoxc8), mRNA","P09025",460,{"v":7e-161,"d":"7.00E-161"},"Homeobox protein Hox-C8",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;GO:0009952|anterior/posterior pattern specification;GO:0030182|neuron differentiation;GO:0048705|skeletal system morphogenesis;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0015630|microtubule cytoskeleton;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09308","HOX_8; homeobox protein HoxB/C/D8"]
["ENSRNOG00000030266",852,54.80953333,2033,131.2542607,0.417582889,-1.259865499,{"v":3.716e-111,"d":"3.72E-111"},{"v":2.431E-110,"d":"2.43E-110"},"down","yes","Plekhg2","protein_coding","chr1:83647748-83665063:-","gi|209529673|ref|NP_001128444.1|",5930,0,"pleckstrin homology domain-containing family G member 2 [Rattus norvegicus]","gi|209529672|ref|NM_001134972.1|",5011,0,"Rattus norvegicus pleckstrin homology and RhoGEF domain containing G2 (Plekhg2), mRNA","Q6KAU7",1990,0,"Pleckstrin homology domain-containing family G member 2",".",".",".",".","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0030833|regulation of actin filament polymerization;GO:0050790|regulation of catalytic activity;",".","GO:0005085|guanyl-nucleotide exchange factor activity;","K23859","PLEKHG1_2_3; pleckstrin homology domain-containing family G member 1/2/3"]
["ENSRNOG00000050104",117,7.526661268,738,47.64665243,0.157968312,-2.662292906,{"v":8.0287e-111,"d":"8.03E-111"},{"v":5.2226E-110,"d":"5.22E-110"},"down","yes","Clip3","protein_coding","chr1:85547206-85563184:+","gi|676275665|gb|KFO30054.1|",2458,0,"CAP-Gly domain-containing linker protein 3 [Fukomys damarensis]","gi|672036058|ref|XM_003748820.3|",3339,0,"PREDICTED: Rattus norvegicus CAP-Gly domain-containing linker protein 3-like (LOC100911911), transcript variant X5, mRNA","B9EHT4",949,0,"CAP-Gly domain-containing linker protein 3","SPAC27D7.13c",74.7,{"v":1e-12,"d":"1.00E-12"},"COG5244","pfam01302","CAP_GLY","CAP-Gly domain. Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove.","GO:0001934|positive regulation of protein phosphorylation;GO:0010828|positive regulation of glucose transmembrane transport;GO:0018230|peptidyl-L-cysteine S-palmitoylation;GO:0031115|negative regulation of microtubule polymerization;GO:0031122|cytoplasmic microtubule organization;GO:0043065|positive regulation of apoptotic process;GO:0044091|membrane biogenesis;GO:0045444|fat cell differentiation;GO:0045807|positive regulation of endocytosis;GO:0098840|protein transport along microtubule;GO:1903078|positive regulation of protein localization to plasma membrane;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005802|trans-Golgi network;GO:0005886|plasma membrane;GO:0031901|early endosome membrane;GO:0032588|trans-Golgi network membrane;GO:0035371|microtubule plus-end;GO:0045121|membrane raft;GO:0055038|recycling endosome membrane;","GO:0008017|microtubule binding;GO:0035594|ganglioside binding;GO:0051010|microtubule plus-end binding;","K10423","CLIP3_4; CAP-Gly domain-containing linker protein 3/4"]
["ENSRNOG00000003732",364,23.4162795,1229,79.34652552,0.295114113,-1.76065518,{"v":2.4638e-110,"d":"2.46E-110"},{"v":1.5954e-109,"d":"1.60E-109"},"down","yes","Flrt2","protein_coding","chr6:114777599-114872785:+","gi|157822675|ref|NP_001100220.1|",3203,0,"leucine-rich repeat transmembrane protein FLRT2 precursor [Rattus norvegicus]","gi|672056498|ref|XM_006240416.2|",6768,0,"PREDICTED: Rattus norvegicus fibronectin leucine rich transmembrane protein 2 (Flrt2), transcript variant X1, mRNA","D3ZTV3",1238,0,"Leucine-rich repeat transmembrane protein FLRT2","STM0800_2",57.4,5e-07,"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0003007|heart morphogenesis;GO:0007411|axon guidance;GO:0008543|fibroblast growth factor receptor signaling pathway;GO:0050919|negative chemotaxis;GO:0051965|positive regulation of synapse assembly;GO:0061343|cell adhesion involved in heart morphogenesis;GO:0071711|basement membrane organization;GO:2001222|regulation of neuron migration;","GO:0005615|extracellular space;GO:0005789|endoplasmic reticulum membrane;GO:0005887|integral component of plasma membrane;GO:0005911|cell-cell junction;GO:0005925|focal adhesion;GO:0043005|neuron projection;GO:0045202|synapse;","GO:0005104|fibroblast growth factor receptor binding;GO:0045499|chemorepellent activity;","K16362","FLRT; leucine-rich repeat transmembrane protein FLRT"]
["ENSRNOG00000008353",11,0.70763482,461,29.7630173,0.023775641,-5.394371941,{"v":2.8663e-110,"d":"2.87E-110"},{"v":1.8539E-109,"d":"1.85E-109"},"down","yes","Iqch","protein_coding","chr8:63892370-64083223:-","gi|672061925|ref|XP_008764459.1|",5587,0,"PREDICTED: IQ domain-containing protein H isoform X4 [Rattus norvegicus]","gi|672061924|ref|XM_008766237.1|",3444,0,"PREDICTED: Rattus norvegicus IQ motif containing H (Iqch), transcript variant X4, mRNA",".",".",".",".",".",".",".",".","pfam00612","IQ","IQ calmodulin-binding motif. Calmodulin-binding motif.",".",".",".","K24842","IQCH; IQ domain-containing protein H"]
["ENSRNOG00000019203",7,0.450313067,457,29.50476986,0.015262382,-6.033876052,{"v":1.3672e-109,"d":"1.37E-109"},{"v":8.7733e-109,"d":"8.77E-109"},"down","yes","Eya2","protein_coding","chr3:154335400-154518793:+","gi|672047942|ref|XP_008760678.1|",2672,0,"PREDICTED: eyes absent homolog 2 isoform X1 [Rattus norvegicus]","gi|672047941|ref|XM_008762456.1|",2169,0,"PREDICTED: Rattus norvegicus EYA transcriptional coactivator and phosphatase 2 (Eya2), transcript variant X1, mRNA","O08575",1005,0,"Eyes absent homolog 2",".",".",".",".","pfam06912","DUF1275","Protein of unknown function (DUF1275). This family consists of several hypothetical bacterial proteins of around 200 residues in length. The function of this family is unknown although a few members are thought to be membrane proteins.","GO:0006281|DNA repair;GO:0006470|protein dephosphorylation;GO:0014706|striated muscle tissue development;GO:0016576|histone dephosphorylation;GO:0030154|cell differentiation;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0045739|positive regulation of DNA repair;GO:0048856|anatomical structure development;GO:0097192|extrinsic apoptotic signaling pathway in absence of ligand;GO:0097345|mitochondrial outer membrane permeabilization;GO:2001240|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;","GO:0000287|magnesium ion binding;GO:0004725|protein tyrosine phosphatase activity;","K17620","EYA2; eyes absent homolog 2 [EC:3.1.3.48]"]
["ENSRNOG00000002217",20,1.286608764,478,30.86056892,0.041691025,-4.584119332,{"v":2.3603E-109,"d":"2.36E-109"},{"v":1.5113e-108,"d":"1.51E-108"},"down","yes","Plac8","protein_coding","chr14:9063048-9074264:+","gi|157820945|ref|NP_001101823.1|",517,{"v":8e-64,"d":"8.00E-64"},"placenta-specific gene 8 protein [Rattus norvegicus]","gi|157820944|ref|NM_001108353.1|",605,0,"Rattus norvegicus placenta-specific 8 (Plac8), mRNA","Q9JI48",202,{"v":1e-64,"d":"1.00E-64"},"Placenta-specific gene 8 protein",".",".",".",".","pfam04749","PLAC8","PLAC8 family. This family includes the Placenta-specific gene 8 protein.","GO:0008284|positive regulation of cell proliferation;GO:0009409|response to cold;GO:0040015|negative regulation of multicellular organism growth;GO:0042742|defense response to bacterium;GO:0043066|negative regulation of apoptotic process;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050873|brown fat cell differentiation;GO:0120162|positive regulation of cold-induced thermogenesis;",".","GO:0003682|chromatin binding;",".","."]
["ENSRNOG00000069663",43,2.766208842,543,35.05708979,0.078905832,-3.663724252,{"v":3.6361e-109,"d":"3.64E-109"},{"v":2.3255e-108,"d":"2.33E-108"},"down","yes","Arl4c","protein_coding","chr9:89298005-89304513:-","gi|29436760|gb|AAH49804.1|",1153,{"v":3e-151,"d":"3.00E-151"},"Arl4c protein, partial [Mus musculus]","gi|75905681|gb|AC166829.3|",1467,0,"Mus musculus BAC clone RP23-299M19 from chromosome 1, complete sequence","P61208",373,{"v":2e-124,"d":"2.00E-124"},"ADP-ribosylation factor-like protein 4C",".",".",".",".","pfam00025","Arf","ADP-ribosylation factor family. Pfam combines a number of different Prosite families together",".",".",".",".","."]
["ENSRNOG00000001224",146,9.392243975,789,50.93930727,0.18438107,-2.43923755,{"v":1.6384e-107,"d":"1.64E-107"},{"v":1.0317e-106,"d":"1.03E-106"},"down","yes","Itgb2","protein_coding","chr20:11061430-11097600:-","gi|163937849|ref|NP_001032869.2|",3677,0,"integrin beta-2 precursor [Rattus norvegicus]","gi|163937848|ref|NM_001037780.2|",3151,0,"Rattus norvegicus integrin, beta 2 (Itgb2), mRNA","P11835",1291,0,"Integrin beta-2",".",".",".",".","pfam00362","Integrin_beta","Integrin, beta chain. Integrins have been found in animals and their homologues have also been found in cyanobacteria, probably due to horizontal gene transfer. The sequences repeats have been trimmed due to an overlap with EGF.","GO:0002523|leukocyte migration involved in inflammatory response;GO:0006898|receptor-mediated endocytosis;GO:0006911|phagocytosis, engulfment;GO:0007155|cell adhesion;GO:0007159|leukocyte cell-cell adhesion;GO:0007160|cell-matrix adhesion;GO:0007229|integrin-mediated signaling pathway;GO:0007568|aging;GO:0016477|cell migration;GO:0030101|natural killer cell activation;GO:0030593|neutrophil chemotaxis;GO:0031623|receptor internalization;GO:0032930|positive regulation of superoxide anion generation;GO:0033627|cell adhesion mediated by integrin;GO:0034113|heterotypic cell-cell adhesion;GO:0035987|endodermal cell differentiation;GO:0043113|receptor clustering;GO:0043315|positive regulation of neutrophil degranulation;GO:0043542|endothelial cell migration;GO:0045123|cellular extravasation;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0045766|positive regulation of angiogenesis;GO:0050730|regulation of peptidyl-tyrosine phosphorylation;GO:0050766|positive regulation of phagocytosis;GO:0050798|activated T cell proliferation;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0071404|cellular response to low-density lipoprotein particle stimulus;GO:0097242|amyloid-beta clearance;GO:0098609|cell-cell adhesion;GO:1904996|positive regulation of leukocyte adhesion to vascular endothelial cell;GO:1990266|neutrophil migration;","GO:0005886|plasma membrane;GO:0005925|focal adhesion;GO:0008305|integrin complex;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0034687|integrin alphaL-beta2 complex;GO:0034688|integrin alphaM-beta2 complex;GO:0043235|receptor complex;GO:0044853|plasma membrane raft;GO:0045121|membrane raft;","GO:0001540|amyloid-beta binding;GO:0001851|complement component C3b binding;GO:0005178|integrin binding;GO:0019901|protein kinase binding;GO:0030369|ICAM-3 receptor activity;GO:0031072|heat shock protein binding;GO:0038024|cargo receptor activity;GO:0044877|protein-containing complex binding;GO:0046872|metal ion binding;GO:0050839|cell adhesion molecule binding;","K06464","ITGB2, CD18; integrin beta 2"]
["ENSRNOG00000001959",42,2.701878404,531,34.28234748,0.078812526,-3.665431247,{"v":7.8406e-107,"d":"7.84E-107"},{"v":4.9155e-106,"d":"4.92E-106"},"down","yes","Mx1","protein_coding","chr11:36799660-36823507:-","gi|71534287|ref|NP_775119.2|",3312,0,"interferon-induced GTP-binding protein Mx1 [Rattus norvegicus]","gi|402692028|ref|NM_173096.3|",3320,0,"Rattus norvegicus myxovirus (influenza virus) resistance 1 (Mx1), transcript variant 1, mRNA","P18588",1270,0,"Interferon-induced GTP-binding protein Mx1","YLL001w",225,{"v":8e-61,"d":"8.00E-61"},"COG0699","pfam01031","Dynamin_M","Dynamin central region. This region lies between the GTPase domain, see pfam00350, and the pleckstrin homology (PH) domain, see pfam00169.","GO:0009615|response to virus;GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0051607|defense response to virus;GO:0070106|interleukin-27-mediated signaling pathway;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005789|endoplasmic reticulum membrane;GO:0005829|cytosol;GO:0005874|microtubule;GO:0016020|membrane;GO:0031965|nuclear membrane;GO:0048471|perinuclear region of cytoplasm;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0008017|microtubule binding;GO:0042802|identical protein binding;","K14754","MX; interferon-induced GTP-binding protein Mx"]
["ENSRNOG00000017511",14,0.900626135,452,29.18196056,0.030862427,-5.01800466,{"v":1.1754e-106,"d":"1.18E-106"},{"v":7.3445e-106,"d":"7.34E-106"},"down","yes","Dcdc2","protein_coding","chr17:39845952-40030743:-","gi|167830444|ref|NP_001099580.2|",2376,0,"doublecortin domain-containing protein 2 [Rattus norvegicus]","gi|167830443|ref|NM_001106110.2|",6788,0,"Rattus norvegicus doublecortin domain containing 2 (Dcdc2), mRNA","D3ZR10",919,0,"Doublecortin domain-containing protein 2",".",".",".",".","pfam03607","DCX","Doublecortin.","GO:0001764|neuron migration;GO:0007605|sensory perception of sound;GO:0008542|visual learning;GO:0019228|neuronal action potential;GO:0030111|regulation of Wnt signaling pathway;GO:0035249|synaptic transmission, glutamatergic;GO:0035556|intracellular signal transduction;GO:0045880|positive regulation of smoothened signaling pathway;GO:0048813|dendrite morphogenesis;GO:0060271|cilium assembly;GO:1902017|regulation of cilium assembly;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005815|microtubule organizing center;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0005874|microtubule;GO:0005929|cilium;GO:0005930|axoneme;GO:0015630|microtubule cytoskeleton;GO:0034451|centriolar satellite;GO:0045202|synapse;GO:0060091|kinocilium;GO:0072686|mitotic spindle;","GO:0019894|kinesin binding;","K23405","DCDC2; doublecortin domain-containing protein 2"]
["ENSRNOG00000017403",124,7.976974335,735,47.45296685,0.168102752,-2.572584749,{"v":2.1572e-106,"d":"2.16E-106"},{"v":1.345E-105,"d":"1.35E-105"},"down","yes","Apobr","protein_coding","chr1:181168916-181173528:+","gi|564331101|ref|XP_006230381.1|",4501,0,"PREDICTED: apolipoprotein B receptor isoform X1 [Rattus norvegicus]","gi|672038542|ref|XM_006230319.2|",3814,0,"PREDICTED: Rattus norvegicus apolipoprotein B receptor (Apobr), transcript variant X1, mRNA","Q8VBT6",1183,0,"Apolipoprotein B receptor",".",".",".",".","pfam04621","ETS_PEA3_N","PEA3 subfamily ETS-domain transcription factor N terminal domain. The N terminus of the PEA3 transcription factors is implicated in transactivation and in inhibition of DNA binding. Transactivation is potentiated by activation of the Ras/MAP kinase and protein kinase A signalling cascades. The N terminal region contains conserved MAP kinase phosphorylation sites.","GO:0006641|triglyceride metabolic process;GO:0006869|lipid transport;GO:0006897|endocytosis;",".","GO:0030229|very-low-density lipoprotein particle receptor activity;",".","."]
["ENSRNOG00000003144",132,8.49161784,753,48.61508032,0.174670448,-2.517292555,{"v":2.2076e-106,"d":"2.21E-106"},{"v":1.3749E-105,"d":"1.37E-105"},"down","yes","Gprc5c","protein_coding","chr10:99887077-99908926:+","gi|564375091|ref|XP_006247740.1|",2622,0,"PREDICTED: G-protein coupled receptor family C group 5 member C isoform X1 [Rattus norvegicus]","gi|211853139|gb|BC168227.1|",4019,0,"Rattus norvegicus G protein-coupled receptor, family C, group 5, member C, mRNA (cDNA clone MGC:188253 IMAGE:7372263), complete cds","Q3KRC4",820,0,"G-protein coupled receptor family C group 5 member C",".",".",".",".","pfam00003","7tm_3","7 transmembrane sweet-taste receptor of 3 GCPR. This is a domain of seven transmembrane regions that forms the C-terminus of some subclass 3 G-coupled-protein receptors. It is often associated with a downstream cysteine-rich linker domain, NCD3G pfam07562, which is the human sweet-taste receptor, and the N-terminal domain, ANF_receptor pfam01094. The seven TM regions assemble in such a way as to produce a docking pocket into which such molecules as cyclamate and lactisole have been found to bind and consequently confer the taste of sweetness.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0032147|activation of protein kinase activity;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0043235|receptor complex;GO:0070062|extracellular exosome;","GO:0004930|G protein-coupled receptor activity;GO:0030295|protein kinase activator activity;","K04620","GPRC5C; G protein-coupled receptor family C group 5 member C"]
["ENSRNOG00000001823",334,21.48636635,1150,74.2461386,0.289393721,-1.788894473,{"v":1.2562E-105,"d":"1.26E-105"},{"v":7.7985e-105,"d":"7.80E-105"},"down","yes","St6gal1","protein_coding","chr11:77526837-77653310:-","gi|164519128|ref|NP_001106815.1|",2095,0,"beta-galactoside alpha-2,6-sialyltransferase 1 isoform 1 [Rattus norvegicus]","gi|298914103|emb|FQ222565.1|",4411,0,"Rattus norvegicus TL0ADA21YL19 mRNA sequence","P13721",808,0,"Beta-galactoside alpha-2,6-sialyltransferase 1",".",".",".",".","pfam00777","Glyco_transf_29","Glycosyltransferase family 29 (sialyltransferase). Members of this family belong to glycosyltransferase family 29.","GO:0006054|N-acetylneuraminate metabolic process;GO:0006486|protein glycosylation;GO:0018279|protein N-linked glycosylation via asparagine;GO:0032946|positive regulation of mononuclear cell proliferation;GO:0045471|response to ethanol;GO:0050922|negative regulation of chemotaxis;GO:0097503|sialylation;GO:1900024|regulation of substrate adhesion-dependent cell spreading;GO:1990743|protein sialylation;GO:2000110|negative regulation of macrophage apoptotic process;","GO:0000138|Golgi trans cisterna;GO:0000139|Golgi membrane;GO:0005576|extracellular region;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005797|Golgi medial cisterna;GO:0016021|integral component of membrane;GO:0032580|Golgi cisterna membrane;","GO:0003835|beta-galactoside alpha-2,6-sialyltransferase activity;GO:0008373|sialyltransferase activity;GO:0042803|protein homodimerization activity;","K00778","SIAT1, ST6GAL1; beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 1) [EC:2.4.99.1]"]
["ENSRNOG00000066973",610,39.24156729,1617,104.3965271,0.375889586,-1.41161915,{"v":2.0889e-105,"d":"2.09E-105"},{"v":1.294E-104,"d":"1.29E-104"},"down","yes","Kctd12","protein_coding","chr15:79801191-79806282:-","gi|564318268|ref|XP_006222111.1|",1433,0,"PREDICTED: BTB/POZ domain-containing protein KCTD12 [Rattus norvegicus]","gi|672078979|ref|XM_006252420.2|",2274,0,"PREDICTED: Rattus norvegicus potassium channel tetramerization domain containing 12 (Kctd12), mRNA","Q6WVG3",553,0,"BTB/POZ domain-containing protein KCTD12",".",".",".",".","pfam02214","BTB_2","BTB/POZ domain. In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.",".",".",".",".","."]
["ENSRNOG00000001216",38,2.444556651,513,33.120234,0.073808556,-3.760068122,{"v":3.8943E-105,"d":"3.89E-105"},{"v":2.4097e-104,"d":"2.41E-104"},"down","yes","Trpm2","protein_coding","chr20:10707014-10753181:+","gi|564397367|ref|XP_006256310.1|",7426,0,"PREDICTED: transient receptor potential cation channel subfamily M member 2 isoform X1 [Rattus norvegicus]","gi|672085964|ref|XM_006256248.2|",5387,0,"PREDICTED: Rattus norvegicus transient receptor potential cation channel, subfamily M, member 2 (Trpm2), transcript variant X1, mRNA","E9PTA2",2849,0,"Transient receptor potential cation channel subfamily M member 2",".",".",".",".","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0001659|temperature homeostasis;GO:0002407|dendritic cell chemotaxis;GO:0006828|manganese ion transport;GO:0009408|response to heat;GO:0014074|response to purine-containing compound;GO:0032024|positive regulation of insulin secretion;GO:0033194|response to hydroperoxide;GO:0035584|calcium-mediated signaling using intracellular calcium source;GO:0035725|sodium ion transmembrane transport;GO:0044849|estrous cycle;GO:0051209|release of sequestered calcium ion into cytosol;GO:0051289|protein homotetramerization;GO:0051489|regulation of filopodium assembly;GO:0070301|cellular response to hydrogen peroxide;GO:0070588|calcium ion transmembrane transport;GO:0071277|cellular response to calcium ion;GO:0071415|cellular response to purine-containing compound;GO:0071421|manganese ion transmembrane transport;GO:0071502|cellular response to temperature stimulus;GO:0071577|zinc ion transmembrane transport;GO:0097028|dendritic cell differentiation;GO:0097553|calcium ion transmembrane import into cytosol;GO:0098655|cation transmembrane transport;GO:0098703|calcium ion import across plasma membrane;GO:1903223|positive regulation of oxidative stress-induced neuron death;GO:2000249|regulation of actin cytoskeleton reorganization;","GO:0005764|lysosome;GO:0005765|lysosomal membrane;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0030659|cytoplasmic vesicle membrane;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043204|perikaryon;","GO:0003674|molecular_function;GO:0005261|cation channel activity;GO:0005272|sodium channel activity;GO:0005384|manganese ion transmembrane transporter activity;GO:0005509|calcium ion binding;GO:0015278|calcium-release channel activity;GO:0072571|mono-ADP-D-ribose binding;GO:0099604|ligand-gated calcium channel activity;","K04977","TRPM2; transient receptor potential cation channel subfamily M member 2 [EC:3.6.1.13]"]
["ENSRNOG00000009425",54,3.473843662,557,35.96095583,0.096600426,-3.371826635,{"v":5.0797e-105,"d":"5.08E-105"},{"v":3.133e-104,"d":"3.13E-104"},"down","yes","Fgf7","protein_coding","chr3:113281283-113332929:+","gi|537151192|gb|ERE71530.1|",1063,{"v":2e-134,"d":"2.00E-134"},"keratinocyte growth factor-like protein [Cricetulus griseus]","gi|672046795|ref|XM_006234903.2|",1484,0,"PREDICTED: Rattus norvegicus fibroblast growth factor 7 (Fgf7), transcript variant X1, mRNA","P36363",368,{"v":5e-120,"d":"5.00E-120"},"Fibroblast growth factor 7",".",".",".",".","pfam00167","FGF","Fibroblast growth factor. Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide range of contexts. They are found in a wide range of organisms, from nematodes to humans. Most share an internal core region of high similarity, conserved residues in which are involved in binding with their receptors. On binding, they cause dimerization of their tyrosine kinase receptors leading to intracellular signalling. There are currently four known tyrosine kinase receptors for fibroblast growth factors. These receptors can each bind several different members of this family. Members of this family have a beta trefoil structure. Most have N-terminal signal peptides and are secreted. A few lack signal sequences but are secreted anyway; still others also lack the signal peptide but are found on the cell surface and within the extracellular matrix. A third group remain intracellular. They have central roles in development, regulating cell proliferation, migration and differentiation. On the other hand, they are important in tissue repair following injury in adult organisms.","GO:0001541|ovarian follicle development;GO:0001934|positive regulation of protein phosphorylation;GO:0006656|phosphatidylcholine biosynthetic process;GO:0008284|positive regulation of cell proliferation;GO:0008543|fibroblast growth factor receptor signaling pathway;GO:0008654|phospholipid biosynthetic process;GO:0009887|animal organ morphogenesis;GO:0010463|mesenchymal cell proliferation;GO:0010628|positive regulation of gene expression;GO:0010838|positive regulation of keratinocyte proliferation;GO:0030154|cell differentiation;GO:0030324|lung development;GO:0030334|regulation of cell migration;GO:0031069|hair follicle morphogenesis;GO:0031532|actin cytoskeleton reorganization;GO:0034394|protein localization to cell surface;GO:0042060|wound healing;GO:0043129|surfactant homeostasis;GO:0045893|positive regulation of transcription, DNA-templated;GO:0050679|positive regulation of epithelial cell proliferation;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050918|positive chemotaxis;GO:0051549|positive regulation of keratinocyte migration;GO:0051781|positive regulation of cell division;GO:0060445|branching involved in salivary gland morphogenesis;GO:0060501|positive regulation of epithelial cell proliferation involved in lung morphogenesis;GO:0060665|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling;GO:0061033|secretion by lung epithelial cell involved in lung growth;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;","GO:0005104|fibroblast growth factor receptor binding;GO:0005111|type 2 fibroblast growth factor receptor binding;GO:0008083|growth factor activity;GO:0008201|heparin binding;GO:0042056|chemoattractant activity;","K04358","FGF; fibroblast growth factor"]
["ENSRNOG00000032246",40,2.573217527,518,33.4430433,0.076943282,-3.700060812,{"v":5.8015e-105,"d":"5.80E-105"},{"v":3.5743e-104,"d":"3.57E-104"},"down","yes","Acsm3","protein_coding","chr1:174133288-174160184:+","gi|65301416|ref|NP_150234.1|",3142,0,"acyl-coenzyme A synthetase ACSM3, mitochondrial [Rattus norvegicus]","gi|65301415|ref|NM_033231.1|",2552,0,"Rattus norvegicus acyl-CoA synthetase medium-chain family member 3 (Acsm3), mRNA","Q6SKG1",1214,0,"Acyl-coenzyme A synthetase ACSM3, mitochondrial","MA2912",447,{"v":8e-146,"d":"8.00E-146"},"COG0365","pfam00501","AMP-binding","AMP-binding enzyme.","GO:0006633|fatty acid biosynthetic process;GO:0006637|acyl-CoA metabolic process;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005739|mitochondrion;GO:0005759|mitochondrial matrix;","GO:0003674|molecular_function;GO:0004321|fatty-acyl-CoA synthase activity;GO:0005524|ATP binding;GO:0015645|fatty acid ligase activity;GO:0018729|propionate CoA-transferase activity;GO:0043759|branched-chain acyl-CoA synthetase (ADP-forming) activity;GO:0046872|metal ion binding;GO:0047760|butyrate-CoA ligase activity;GO:0050218|propionate-CoA ligase activity;","K01896","ACSM; medium-chain acyl-CoA synthetase [EC:6.2.1.2]"]
["ENSRNOG00000052256",126,8.105635211,733,47.32384313,0.171280156,-2.545570084,{"v":6.8368e-105,"d":"6.84E-105"},{"v":4.2076e-104,"d":"4.21E-104"},"down","yes","Dact3","protein_coding","chr1:77546900-77558630:+","gi|300794492|ref|NP_001178876.1|",1337,{"v":8e-170,"d":"8.00E-170"},"dapper homolog 3 [Rattus norvegicus]","gi|300794491|ref|NM_001191947.1|",2794,0,"Rattus norvegicus dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis) (Dact3), mRNA","Q0PHV7",514,{"v":2E-169,"d":"2.00E-169"},"Dapper homolog 3",".",".",".",".","pfam15268","Dapper","Dapper. This is a family of signalling proteins. They act in a diverse range of signaling pathways and have a range of binding partners. They act as homo- and heterodimers.","GO:0010719|negative regulation of epithelial to mesenchymal transition;GO:0030178|negative regulation of Wnt signaling pathway;GO:0030308|negative regulation of cell growth;GO:0090090|negative regulation of canonical Wnt signaling pathway;","GO:0005737|cytoplasm;","GO:0005080|protein kinase C binding;GO:0042802|identical protein binding;GO:0051018|protein kinase A binding;GO:0070097|delta-catenin binding;","K22154","DACT; dapper"]
["ENSRNOG00000022565",71,4.567461111,601,38.80167765,0.11771298,-3.086654681,{"v":7.9116e-105,"d":"7.91E-105"},{"v":4.8639e-104,"d":"4.86E-104"},"down","yes","Lrrc25","protein_coding","chr16:18806890-18813671:-","gi|62662417|ref|XP_573882.1|",1630,0,"PREDICTED: leucine-rich repeat-containing protein 25 isoform X1 [Rattus norvegicus]","gi|672029252|ref|XM_001070537.5|",3599,0,"PREDICTED: Rattus norvegicus leucine rich repeat containing 25 (Lrrc25), transcript variant X1, mRNA","Q8K1T1",424,{"v":1E-134,"d":"1.00E-134"},"Leucine-rich repeat-containing protein 25",".",".",".",".","pfam00019","TGF_beta","Transforming growth factor beta like domain.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000006952",202,12.99474851,893,57.65374067,0.225392982,-2.149485502,{"v":1.5766E-104,"d":"1.58E-104"},{"v":9.6822e-104,"d":"9.68E-104"},"down","yes","Prex1","protein_coding","chr3:155306950-155456688:-","gi|208973288|ref|NP_001129190.1|",8373,0,"phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [Rattus norvegicus]","gi|208973287|ref|NM_001135718.1|",5435,0,"Rattus norvegicus phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 (Prex1), mRNA","Q69ZK0",3115,0,"Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein",".",".",".",".","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0030217|T cell differentiation;GO:0030335|positive regulation of cell migration;GO:0030593|neutrophil chemotaxis;GO:0030833|regulation of actin filament polymerization;GO:0035556|intracellular signal transduction;GO:0043547|positive regulation of GTPase activity;GO:0045785|positive regulation of cell adhesion;GO:0050773|regulation of dendrite development;GO:0072593|reactive oxygen species metabolic process;GO:1900026|positive regulation of substrate adhesion-dependent cell spreading;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0030426|growth cone;GO:0043198|dendritic shaft;GO:0048471|perinuclear region of cytoplasm;","GO:0003674|molecular_function;GO:0005085|guanyl-nucleotide exchange factor activity;GO:0005543|phospholipid binding;","K12365","PREX1; phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchanger 1 protein"]
["ENSRNOG00000016712",397,25.53918396,1256,81.08969573,0.314949806,-1.666806171,{"v":1.6668E-104,"d":"1.67E-104"},{"v":1.0225E-103,"d":"1.02E-103"},"down","yes","Lhcgr","protein_coding","chr6:5661871-5724521:+","gi|6981160|ref|NP_037110.1|",3342,0,"lutropin-choriogonadotropic hormone receptor precursor [Rattus norvegicus]","gi|6981159|ref|NM_012978.1|",2670,0,"Rattus norvegicus luteinizing hormone/choriogonadotropin receptor (Lhcgr), mRNA","P16235",1291,0,"Lutropin-choriogonadotropic hormone receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001541|ovarian follicle development;GO:0006622|protein targeting to lysosome;GO:0007188|adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007190|activation of adenylate cyclase activity;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007283|spermatogenesis;GO:0007417|central nervous system development;GO:0008584|male gonad development;GO:0008585|female gonad development;GO:0009410|response to xenobiotic stimulus;GO:0009755|hormone-mediated signaling pathway;GO:0010524|positive regulation of calcium ion transport into cytosol;GO:0022602|ovulation cycle process;GO:0032962|positive regulation of inositol trisphosphate biosynthetic process;GO:0034699|response to luteinizing hormone;GO:0042700|luteinizing hormone signaling pathway;GO:0046544|development of secondary male sexual characteristics;GO:0046886|positive regulation of hormone biosynthetic process;GO:0050482|arachidonic acid secretion;GO:0050810|regulation of steroid biosynthetic process;GO:0050850|positive regulation of calcium-mediated signaling;GO:0050890|cognition;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;GO:0060065|uterus development;GO:0071371|cellular response to gonadotropin stimulus;GO:0071373|cellular response to luteinizing hormone stimulus;GO:0072520|seminiferous tubule development;GO:0090030|regulation of steroid hormone biosynthetic process;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0005768|endosome;GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0031233|intrinsic component of external side of plasma membrane;GO:0043235|receptor complex;","GO:0004964|luteinizing hormone receptor activity;GO:0008528|G protein-coupled peptide receptor activity;GO:0017046|peptide hormone binding;GO:0035472|choriogonadotropin hormone receptor activity;GO:0038106|choriogonadotropin hormone binding;GO:0042802|identical protein binding;GO:0051117|ATPase binding;","K04248","LHCGR; lutropin-choriogonadotropic hormone receptor"]
["ENSRNOG00000047977",684,44.00201972,1728,111.5628935,0.394414472,-1.342215607,{"v":2.4449e-104,"d":"2.44E-104"},{"v":1.495E-103,"d":"1.50E-103"},"down","yes","Tcim","lncRNA","chr16:67593410-67597581:+","gi|169234824|ref|NP_001108515.1|",551,{"v":1e-63,"d":"1.00E-63"},"uncharacterized protein LOC684871 [Rattus norvegicus]","gi|672080595|ref|XM_003751622.3|",1555,0,"PREDICTED: Rattus norvegicus uncharacterized LOC100910163 (LOC100910163), mRNA","Q9D915",212,{"v":2e-63,"d":"2.00E-63"},"Transcriptional and immune response regulator",".",".",".",".","pfam15063","TC1","Thyroid cancer protein 1. Thyroid cancer protein 1 (TC1) is thought to decrease in apoptosis and increase cell proliferation. It is found to be expressed in thyroid papillary carcinoma. This suggests its importance in thyroid cancer. The molecular mechanism of TC1, involves up-regulating cell signalling through ERK-1/2 signalling pathway and it positively regulates transition between the G1 and S phase in the cell cycle. It is thought to positively regulate Wnt/beta-catenin signalling pathway by interacting with its repressor. In humans, it is located in the chromosomal position, C8orf4. This family of proteins is found in eukaryotes and contains a conserved NIF sequence motif.","GO:0002264|endothelial cell activation involved in immune response;GO:0010739|positive regulation of protein kinase A signaling;GO:0034605|cellular response to heat;GO:0043066|negative regulation of apoptotic process;GO:0043620|regulation of DNA-templated transcription in response to stress;GO:0045746|negative regulation of Notch signaling pathway;GO:1900020|positive regulation of protein kinase C activity;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1902806|regulation of cell cycle G1/S phase transition;GO:1903706|regulation of hemopoiesis;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016607|nuclear speck;","GO:0005112|Notch binding;",".","."]
["ENSRNOG00000003064",47,3.023530595,535,34.54059492,0.087535568,-3.513986849,{"v":2.6442e-104,"d":"2.64E-104"},{"v":1.6152e-103,"d":"1.62E-103"},"down","yes","Bst1","protein_coding","chr14:67252998-67270180:-","gi|13540658|ref|NP_110475.1|",1366,0,"ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 precursor [Rattus norvegicus]","gi|74208693|dbj|AK164028.1|",994,0,"Mus musculus 7 days embryo whole body cDNA, RIKEN full-length enriched library, clone:C430019G14 product:bone marrow stromal cell antigen 1, full insert sequence","Q63072",529,0,"ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2",".",".",".",".","pfam02267","Rib_hydrolayse","ADP-ribosyl cyclase. ADP-ribosyl cyclase EC:3.2.2.5 (also know as cyclic ADP-ribose hydrolase or CD38) synthesizes cyclic-ADP ribose, a second messenger for glucose-induced insulin secretion.","GO:0001952|regulation of cell-matrix adhesion;GO:0008150|biological_process;GO:0008284|positive regulation of cell proliferation;GO:0030890|positive regulation of B cell proliferation;GO:0032956|regulation of actin cytoskeleton organization;GO:0050727|regulation of inflammatory response;GO:0050730|regulation of peptidyl-tyrosine phosphorylation;GO:0050848|regulation of calcium-mediated signaling;GO:0090022|regulation of neutrophil chemotaxis;","GO:0001931|uropod;GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0019898|extrinsic component of membrane;GO:0031225|anchored component of membrane;","GO:0003674|molecular_function;GO:0003953|NAD+ nucleosidase activity;GO:0016740|transferase activity;GO:0016849|phosphorus-oxygen lyase activity;GO:0050135|NAD(P)+ nucleosidase activity;GO:0061809|NAD+ nucleotidase, cyclic ADP-ribose generating;GO:0061811|ADP-ribosyl cyclase activity;GO:0061812|cyclic ADP-ribose hydrolase;","K18152","BST1, CD157; ADP-ribosyl cyclase 2 [EC:3.2.2.6 2.4.99.20]"]
["ENSRNOG00000008409",214,13.76671377,913,58.94497787,0.233551937,-2.098184683,{"v":1.1324E-103,"d":"1.13E-103"},{"v":6.8874e-103,"d":"6.89E-103"},"down","yes","Myo1f","protein_coding","chr7:14363350-14413911:+","gi|157821107|ref|NP_001101546.1|",5505,0,"myosin-If [Rattus norvegicus]","gi|157821106|ref|NM_001108076.1|",3361,0,"Rattus norvegicus myosin IF (Myo1f), mRNA","O00160",2027,0,"Unconventional myosin-If","YMR109w",761,0,"COG5022","pfam00063","Myosin_head","Myosin head (motor domain).","GO:0002446|neutrophil mediated immunity;GO:0007015|actin filament organization;GO:0007162|negative regulation of cell adhesion;GO:0009617|response to bacterium;GO:0030050|vesicle transport along actin filament;GO:0030335|positive regulation of cell migration;GO:0032956|regulation of actin cytoskeleton organization;GO:0043312|neutrophil degranulation;GO:0045088|regulation of innate immune response;GO:0050830|defense response to Gram-positive bacterium;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005902|microvillus;GO:0015629|actin cytoskeleton;GO:0016459|myosin complex;GO:0030864|cortical actin cytoskeleton;GO:0031941|filamentous actin;GO:0031982|vesicle;","GO:0000146|microfilament motor activity;GO:0005516|calmodulin binding;GO:0005524|ATP binding;GO:0051015|actin filament binding;","K10356","MYO1; myosin I"]
["ENSRNOG00000011680",97,6.240052504,659,42.54626551,0.146665105,-2.769402432,{"v":2.5867e-103,"d":"2.59E-103"},{"v":1.5716E-102,"d":"1.57E-102"},"down","yes","Il16","protein_coding","chr1:137617944-137718130:-","gi|672037391|ref|XP_008757821.1|",6054,0,"PREDICTED: pro-interleukin-16 isoform X3 [Rattus norvegicus]","gi|672037390|ref|XM_008759599.1|",4894,0,"PREDICTED: Rattus norvegicus interleukin 16 (Il16), transcript variant X1, mRNA","O54824",2101,0,"Pro-interleukin-16",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.","GO:0007165|signal transduction;GO:0008150|biological_process;GO:0010628|positive regulation of gene expression;GO:0019221|cytokine-mediated signaling pathway;GO:0030595|leukocyte chemotaxis;GO:0032722|positive regulation of chemokine production;GO:0032730|positive regulation of interleukin-1 alpha production;GO:0032735|positive regulation of interleukin-12 production;GO:0032755|positive regulation of interleukin-6 production;GO:0050729|positive regulation of inflammatory response;GO:0050930|induction of positive chemotaxis;GO:0051924|regulation of calcium ion transport;GO:1902565|positive regulation of neutrophil activation;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005925|focal adhesion;GO:0016607|nuclear speck;GO:0090543|Flemming body;","GO:0003674|molecular_function;GO:0005125|cytokine activity;GO:0042609|CD4 receptor binding;","K22628","IL16; interleukin 16"]
["ENSRNOG00000000368",25,1.608260955,468,30.21495032,0.053227324,-4.231689149,{"v":3.3553e-103,"d":"3.36E-103"},{"v":2.0364E-102,"d":"2.04E-102"},"down","yes","Grik2","protein_coding","chr20:52133851-52838375:-","gi|3287965|sp|P42260.2|GRIK2_RAT",4799,0,"RecName: Full=Glutamate receptor ionotropic, kainate 2; Short=GluK2; AltName: Full=Glutamate receptor 6; Short=GluR-6; Short=GluR6; Flags: Precursor","gi|56281|emb|Z11548.1|",4498,0,"R.norvegicus cDNA for glutamate receptor subunit (GluR6), kainate subtype","P42260",1853,0,"Glutamate receptor ionotropic, kainate 2",".",".",".",".","pfam00060","Lig_chan","Ligand-gated ion channel. This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.","GO:0001662|behavioral fear response;GO:0006874|cellular calcium ion homeostasis;GO:0006886|intracellular protein transport;GO:0007268|chemical synaptic transmission;GO:0019228|neuronal action potential;GO:0034220|ion transmembrane transport;GO:0035235|ionotropic glutamate receptor signaling pathway;GO:0035249|synaptic transmission, glutamatergic;GO:0042391|regulation of membrane potential;GO:0043113|receptor clustering;GO:0043524|negative regulation of neuron apoptotic process;GO:0043525|positive regulation of neuron apoptotic process;GO:0046328|regulation of JNK cascade;GO:0048169|regulation of long-term neuronal synaptic plasticity;GO:0048172|regulation of short-term neuronal synaptic plasticity;GO:0050804|modulation of chemical synaptic transmission;GO:0050806|positive regulation of synaptic transmission;GO:0051402|neuron apoptotic process;GO:0051967|negative regulation of synaptic transmission, glutamatergic;GO:0060079|excitatory postsynaptic potential;GO:0060080|inhibitory postsynaptic potential;GO:0099505|regulation of presynaptic membrane potential;GO:0120169|detection of cold stimulus involved in thermoception;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0008328|ionotropic glutamate receptor complex;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0032839|dendrite cytoplasm;GO:0032983|kainate selective glutamate receptor complex;GO:0042734|presynaptic membrane;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0043204|perikaryon;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0098686|hippocampal mossy fiber to CA3 synapse;GO:0098978|glutamatergic synapse;","GO:0004970|ionotropic glutamate receptor activity;GO:0005234|extracellularly glutamate-gated ion channel activity;GO:0005515|protein binding;GO:0008066|glutamate receptor activity;GO:0015276|ligand-gated ion channel activity;GO:0015277|kainate selective glutamate receptor activity;GO:0030165|PDZ domain binding;GO:0031624|ubiquitin conjugating enzyme binding;GO:0031625|ubiquitin protein ligase binding;GO:0038023|signaling receptor activity;GO:0042802|identical protein binding;GO:0099507|ligand-gated ion channel activity involved in regulation of presynaptic membrane potential;GO:1904315|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K05202","GRIK2; glutamate receptor, ionotropic kainate 2"]
["ENSRNOG00000002312",729,46.89688944,1790,115.5657288,0.40580274,-1.301149487,{"v":4.7471e-103,"d":"4.75E-103"},{"v":2.8781e-102,"d":"2.88E-102"},"down","yes","Atp10d","protein_coding","chr14:35912141-36012564:-","gi|672076302|ref|XP_008768400.1|",7058,0,"PREDICTED: probable phospholipid-transporting ATPase VD isoform X2 [Rattus norvegicus]","gi|672076301|ref|XM_008770178.1|",4201,0,"PREDICTED: Rattus norvegicus ATPase, class V, type 10D (Atp10d), transcript variant X2, mRNA","Q8K2X1",2606,0,"Probable phospholipid-transporting ATPase VD",".",".",".",".","pfam13246","Hydrolase_like2","Putative hydrolase of sodium-potassium ATPase alpha subunit. This is a putative hydrolase of the sodium-potassium ATPase alpha subunit.","GO:0045332|phospholipid translocation;","GO:0005654|nucleoplasm;GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:1990531|phospholipid-translocating ATPase complex;","GO:0000287|magnesium ion binding;GO:0005524|ATP binding;","K01530","E7.6.2.1; phospholipid-translocating ATPase [EC:7.6.2.1]"]
["ENSRNOG00000024435",93,5.982730751,646,41.70696134,0.143446815,-2.801412163,{"v":1.6746E-102,"d":"1.67E-102"},{"v":1.0089e-101,"d":"1.01E-101"},"down","yes","Galnt17","protein_coding","chr12:25322701-25781290:+","gi|68341983|ref|NP_001020283.1|",2980,0,"putative polypeptide N-acetylgalactosaminyltransferase-like protein 3 [Rattus norvegicus]","gi|46812634|gb|BC069177.1|",2375,0,"Mus musculus Williams-Beuren syndrome chromosome region 17 homolog (human), mRNA (cDNA clone IMAGE:6821510), partial cds","Q7TT15",1149,0,"Polypeptide N-acetylgalactosaminyltransferase 17",".",".",".",".","pfam00535","Glycos_transf_2","Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.",".","GO:0016021|integral component of membrane;","GO:0030246|carbohydrate binding;","K00710","GALNT; polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41]"]
["ENSRNOG00000013794",392,25.21753177,1234,79.66933481,0.316527455,-1.659597454,{"v":4.3474e-102,"d":"4.35E-102"},{"v":2.6136E-101,"d":"2.61E-101"},"down","yes","Rbp1","protein_coding","chr8:99025206-99046743:+","gi|625256169|ref|XP_007619433.1|",765,{"v":1E-99,"d":"1.00E-99"},"PREDICTED: LOW QUALITY PROTEIN: retinol-binding protein 1 [Cricetulus griseus]","gi|298881846|emb|FQ210835.1|",711,0,"Rattus norvegicus TL0ABA21YE24 mRNA sequence","P02696",283,{"v":1e-95,"d":"1.00E-95"},"Retinol-binding protein 1",".",".",".",".","pfam00061","Lipocalin","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.","GO:0002138|retinoic acid biosynthetic process;GO:0006776|vitamin A metabolic process;GO:0030852|regulation of granulocyte differentiation;GO:0033189|response to vitamin A;GO:0042572|retinol metabolic process;GO:0042573|retinoic acid metabolic process;GO:0055088|lipid homeostasis;","GO:0005654|nucleoplasm;GO:0005811|lipid droplet;GO:0005829|cytosol;GO:0044297|cell body;","GO:0016918|retinal binding;GO:0019841|retinol binding;GO:1904768|all-trans-retinol binding;",".","."]
["ENSRNOG00000005034",919,59.11967269,2072,133.7721732,0.441942979,-1.178067856,{"v":4.5692E-102,"d":"4.57E-102"},{"v":2.7412e-101,"d":"2.74E-101"},"down","yes","Arhgef25","protein_coding","chr7:63005940-63013719:-","gi|564359592|ref|XP_006241520.1|",2342,0,"PREDICTED: rho guanine nucleotide exchange factor 25 isoform X5 [Rattus norvegicus]","gi|672058799|ref|XM_006241458.2|",1973,0,"PREDICTED: Rattus norvegicus Rho guanine nucleotide exchange factor (GEF) 25 (Arhgef25), transcript variant X5, mRNA","Q9CWR0",837,0,"Rho guanine nucleotide exchange factor 25",".",".",".",".","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0035023|regulation of Rho protein signal transduction;GO:0050790|regulation of catalytic activity;","GO:0005886|plasma membrane;GO:0030016|myofibril;GO:0030017|sarcomere;","GO:0005085|guanyl-nucleotide exchange factor activity;","K20690","ARHGEF25; Rho guanine nucleotide exchange factor 25"]
["ENSRNOG00000007583",1199,77.13219538,2480,160.1134119,0.481734756,-1.053689081,{"v":4.878e-102,"d":"4.88E-102"},{"v":2.9234e-101,"d":"2.92E-101"},"down","yes","Pygb","protein_coding","chr3:139611749-139663553:+","gi|183986548|gb|AAI66475.1|",4413,0,"Pygb protein [Rattus norvegicus]","gi|183986547|gb|BC166475.1|",4147,0,"Rattus norvegicus phosphorylase, glycogen; brain, mRNA (cDNA clone MGC:187917 IMAGE:9100353), complete cds","P53534",1582,0,"Glycogen phosphorylase, brain form (Fragment)","CPn0307",822,0,"COG0058","pfam00343","Phosphorylase","Carbohydrate phosphorylase. The members of this family catalyse the formation of glucose 1-phosphate from one of the following polyglucoses; glycogen, starch, glucan or maltodextrin.","GO:0005977|glycogen metabolic process;GO:0005980|glycogen catabolic process;","GO:0005737|cytoplasm;GO:0030424|axon;","GO:0008184|glycogen phosphorylase activity;GO:0030170|pyridoxal phosphate binding;GO:0030246|carbohydrate binding;GO:0042802|identical protein binding;GO:0097159|organic cyclic compound binding;GO:0102250|linear malto-oligosaccharide phosphorylase activity;GO:0102499|SHG alpha-glucan phosphorylase activity;","K00688","PYG, glgP; glycogen phosphorylase [EC:2.4.1.1]"]
["ENSRNOG00000020590",770,49.5344374,1843,118.9875073,0.41629948,-1.264306339,{"v":1.7034e-101,"d":"1.70E-101"},{"v":1.0145E-100,"d":"1.01E-100"},"down","yes","Adam15","protein_coding","chr2:174754633-174765113:-","gi|564337373|ref|XP_006232804.1|",3924,0,"PREDICTED: disintegrin and metalloproteinase domain-containing protein 15 isoform X2 [Rattus norvegicus]","gi|672043113|ref|XM_006232742.2|",2904,0,"PREDICTED: Rattus norvegicus ADAM metallopeptidase domain 15 (Adam15), transcript variant X2, mRNA","Q9QYV0",1515,0,"Disintegrin and metalloproteinase domain-containing protein 15",".",".",".",".","pfam01421","Reprolysin","Reprolysin (M12B) family zinc metalloprotease. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as human ADAM8 and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.","GO:0001525|angiogenesis;GO:0001953|negative regulation of cell-matrix adhesion;GO:0002418|immune response to tumor cell;GO:0006508|proteolysis;GO:0007229|integrin-mediated signaling pathway;GO:0008584|male gonad development;GO:0030308|negative regulation of cell growth;GO:0030336|negative regulation of cell migration;GO:0030574|collagen catabolic process;GO:0042246|tissue regeneration;GO:0045087|innate immune response;GO:0060317|cardiac epithelial to mesenchymal transition;GO:0098609|cell-cell adhesion;GO:1900121|negative regulation of receptor binding;GO:1904628|cellular response to phorbol 13-acetate 12-myristate;GO:1990910|response to hypobaric hypoxia;","GO:0001669|acrosomal vesicle;GO:0005615|extracellular space;GO:0005912|adherens junction;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0031514|motile cilium;GO:0070062|extracellular exosome;","GO:0004222|metalloendopeptidase activity;GO:0005178|integrin binding;GO:0008237|metallopeptidase activity;GO:0017124|SH3 domain binding;GO:0046872|metal ion binding;","K06836","ADAM15; disintegrin and metalloproteinase domain-containing protein 15 [EC:3.4.24.-]"]
["ENSRNOG00000015967",826,53.13694194,1924,124.217018,0.427775057,-1.225075732,{"v":7.4022e-101,"d":"7.40E-101"},{"v":4.4038e-100,"d":"4.40E-100"},"down","yes","ENSRNOG00000015967","protein_coding","chr5:146354152-146355331:-","gi|157821467|ref|NP_001100158.1|",418,{"v":5e-49,"d":"5.00E-49"},"SH3 domain-binding glutamic acid-rich-like protein 3 [Rattus norvegicus]","gi|157821466|ref|NM_001106688.1|",577,0,"Rattus norvegicus SH3 domain binding glutamate-rich protein like 3 (Sh3bgrl3), mRNA","Q91VW3",162,{"v":4e-49,"d":"4.00E-49"},"SH3 domain-binding glutamic acid-rich-like protein 3",".",".",".",".","pfam04908","SH3BGR","SH3-binding, glutamic acid-rich protein.",".","GO:0016604|nuclear body;",".","K23740","SH3BGR; SH3 domain-binding glutamic acid-rich protein"]
["ENSRNOG00000058545",163,10.48586142,794,51.26211657,0.204553813,-2.289447662,{"v":1.605E-100,"d":"1.61E-100"},{"v":9.5187e-100,"d":"9.52E-100"},"down","yes","ENSRNOG00000058545","protein_coding","chrX:151632454-151651128:-","gi|78486570|ref|NP_653341.2|",4443,0,"rho GTPase-activating protein 4 [Rattus norvegicus]","gi|53830690|gb|AY742900.1|",6946,0,"Rattus norvegicus Rho GTPase activating protein 4 (Arhgap4) mRNA, complete cds","P98171",1361,0,"Rho GTPase-activating protein 4",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007165|signal transduction;GO:0007399|nervous system development;GO:0010764|negative regulation of fibroblast migration;GO:0030336|negative regulation of cell migration;GO:0030517|negative regulation of axon extension;GO:0035023|regulation of Rho protein signal transduction;GO:0050790|regulation of catalytic activity;","GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005874|microtubule;GO:0030426|growth cone;","GO:0005096|GTPase activator activity;GO:0042802|identical protein binding;","K20122","ARHGAP4; Rho GTPase-activating protein 4"]
["ENSRNOG00000066264",79,5.082104617,603,38.93080137,0.130541999,-2.937414063,{"v":2.1581e-100,"d":"2.16E-100"},{"v":1.2773e-99,"d":"1.28E-99"},"down","yes","RGD1563400","protein_coding","chr12:18566837-18582202:-","gi|564323654|ref|XP_006227213.1|",1042,{"v":8e-130,"d":"8.00E-130"},"PREDICTED: paired immunoglobulin-like type 2 receptor beta-2 isoform X1 [Rattus norvegicus]","gi|672072478|ref|XM_008769083.1|",1467,0,"PREDICTED: Rattus norvegicus similar to paired immunoglobin-like type 2 receptor beta (RGD1563400), transcript variant X7, mRNA","Q2YFS2",289,{"v":4e-88,"d":"4.00E-88"},"Paired immunoglobulin-like type 2 receptor beta",".",".",".",".","pfam13871","Helicase_C_4","Helicase_C-like. Strawberry notch proteins carry DExD/H-box groups and Helicase_C domains. These proteins promote the expression of diverse targets, potentially through interactions with transcriptional activator or repressor complexes.",".",".",".",".","."]
["ENSRNOG00000005082",22,1.41526964,447,28.85915127,0.049040584,-4.349880022,{"v":4.9319e-100,"d":"4.93E-100"},{"v":2.9129e-99,"d":"2.91E-99"},"down","yes","Irf6","protein_coding","chr13:104672179-104691386:+","gi|1685128|gb|AAB36714.1|",2302,0,"interferon regulatory factor 6 [Mus musculus]","gi|157819782|ref|NM_001108859.1|",4044,0,"Rattus norvegicus interferon regulatory factor 6 (Irf6), mRNA","P97431",887,0,"Interferon regulatory factor 6",".",".",".",".","pfam10401","IRF-3","Interferon-regulatory factor 3. This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1).  Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.","GO:0002376|immune system process;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008150|biological_process;GO:0008285|negative regulation of cell proliferation;GO:0030216|keratinocyte differentiation;GO:0043588|skin development;GO:0043616|keratinocyte proliferation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048468|cell development;GO:0051726|regulation of cell cycle;GO:0060021|roof of mouth development;GO:0060173|limb development;GO:0060644|mammary gland epithelial cell differentiation;GO:1904888|cranial skeletal system development;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0030054|cell junction;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K10154","IRF6; interferon regulatory factor 6"]
["ENSRNOG00000016575",285,18.33417488,1031,66.5632773,0.275439786,-1.860191128,{"v":5.3054e-100,"d":"5.31E-100"},{"v":3.127E-99,"d":"3.13E-99"},"down","yes","Tnfrsf1b","protein_coding","chr5:157070642-157104206:-","gi|30794230|ref|NP_569110.1|",1934,0,"tumor necrosis factor receptor superfamily member 1B precursor [Rattus norvegicus]","gi|32453424|gb|AY191269.1|",5063,0,"Rattus norvegicus TNFR2 transcript variant 3 mRNA, complete cds","Q80WY6",749,0,"Tumor necrosis factor receptor superfamily member 1B",".",".",".",".","pfam00020","TNFR_c6","TNFR/NGFR cysteine-rich region.","GO:0002718|regulation of cytokine production involved in immune response;GO:0002724|regulation of T cell cytokine production;GO:0003176|aortic valve development;GO:0003177|pulmonary valve development;GO:0003332|negative regulation of extracellular matrix constituent secretion;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007166|cell surface receptor signaling pathway;GO:0007568|aging;GO:0008630|intrinsic apoptotic signaling pathway in response to DNA damage;GO:0010614|negative regulation of cardiac muscle hypertrophy;GO:0031641|regulation of myelination;GO:0031643|positive regulation of myelination;GO:0032496|response to lipopolysaccharide;GO:0033209|tumor necrosis factor-mediated signaling pathway;GO:0042129|regulation of T cell proliferation;GO:0048714|positive regulation of oligodendrocyte differentiation;GO:0050728|negative regulation of inflammatory response;GO:0050779|RNA destabilization;GO:0051044|positive regulation of membrane protein ectodomain proteolysis;GO:0060548|negative regulation of cell death;GO:0071222|cellular response to lipopolysaccharide;GO:0071356|cellular response to tumor necrosis factor;GO:0071363|cellular response to growth factor stimulus;GO:0097191|extrinsic apoptotic signaling pathway;GO:0150077|regulation of neuroinflammatory response;GO:0150079|negative regulation of neuroinflammatory response;GO:1901215|negative regulation of neuron death;GO:1902339|positive regulation of apoptotic process involved in morphogenesis;GO:2001141|regulation of RNA biosynthetic process;","GO:0005634|nucleus;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0043025|neuronal cell body;GO:0043196|varicosity;GO:0045121|membrane raft;GO:0048471|perinuclear region of cytoplasm;","GO:0005031|tumor necrosis factor-activated receptor activity;GO:0031625|ubiquitin protein ligase binding;GO:0043120|tumor necrosis factor binding;","K05141","TNFRSF1B, TNFR2, CD120b; tumor necrosis factor receptor superfamily member 1B"]
["ENSRNOG00000033835",482,31.00727121,1373,88.64343331,0.349797724,-1.515407193,{"v":1.3099E-99,"d":"1.31E-99"},{"v":7.6968e-99,"d":"7.70E-99"},"down","yes","Dnm1","protein_coding","chr3:15604784-15648538:-","gi|755497120|ref|XP_006497713.2|",4100,0,"PREDICTED: dynamin-1 isoform X3 [Mus musculus]","gi|755497119|ref|XM_006497650.2|",3334,0,"PREDICTED: Mus musculus dynamin 1 (Dnm1), transcript variant X2, mRNA","Q05193",1576,0,"Dynamin-1","SPBC12C2.08",489,{"v":9e-155,"d":"9.00E-155"},"COG0699","pfam01031","Dynamin_M","Dynamin central region. This region lies between the GTPase domain, see pfam00350, and the pleckstrin homology (PH) domain, see pfam00169.","GO:0002031|G protein-coupled receptor internalization;GO:0006897|endocytosis;GO:0006898|receptor-mediated endocytosis;GO:0007032|endosome organization;GO:0007605|sensory perception of sound;GO:0008344|adult locomotory behavior;GO:0016185|synaptic vesicle budding from presynaptic endocytic zone membrane;GO:0031623|receptor internalization;GO:0048488|synaptic vesicle endocytosis;GO:0050804|modulation of chemical synaptic transmission;GO:0051932|synaptic transmission, GABAergic;GO:1900242|regulation of synaptic vesicle endocytosis;GO:1900244|positive regulation of synaptic vesicle endocytosis;GO:1901998|toxin transport;GO:1903423|positive regulation of synaptic vesicle recycling;GO:1904645|response to amyloid-beta;","GO:0001917|photoreceptor inner segment;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005874|microtubule;GO:0005886|plasma membrane;GO:0008021|synaptic vesicle;GO:0016020|membrane;GO:0030117|membrane coat;GO:0032991|protein-containing complex;GO:0043196|varicosity;GO:0045202|synapse;GO:0098684|photoreceptor ribbon synapse;GO:0098835|presynaptic endocytic zone membrane;GO:0098978|glutamatergic synapse;","GO:0003924|GTPase activity;GO:0005515|protein binding;GO:0005525|GTP binding;GO:0008017|microtubule binding;GO:0008022|protein C-terminus binding;GO:0017124|SH3 domain binding;GO:0019901|protein kinase binding;GO:0031749|D2 dopamine receptor binding;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;GO:0050998|nitric-oxide synthase binding;","K01528","DNM1_3; dynamin 1/3 [EC:3.6.5.5]"]
["ENSRNOG00000028259",12,0.771965258,419,27.0514192,0.02853696,-5.131024552,{"v":1.5559e-99,"d":"1.56E-99"},{"v":9.1327e-99,"d":"9.13E-99"},"down","yes","Mcemp1","protein_coding","chr12:1718730-1725986:+","gi|672072052|ref|XP_008767209.1|",1405,0,"PREDICTED: mast cell-expressed membrane protein 1 isoform X1 [Rattus norvegicus]","gi|672072051|ref|XM_008768987.1|",1429,0,"PREDICTED: Rattus norvegicus mast cell-expressed membrane protein 1 (Mcemp1), transcript variant X1, mRNA","Q9D8U6",262,{"v":9e-83,"d":"9.00E-83"},"Mast cell-expressed membrane protein 1",".",".",".",".","pfam03954","Lectin_N","Hepatic lectin, N-terminal domain.",".","GO:0016021|integral component of membrane;","GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000003018",1154,74.23732567,2394,154.561092,0.480310567,-1.057960548,{"v":3.3033e-99,"d":"3.30E-99"},{"v":1.92904e-98,"d":"1.93E-98"},"down","yes","Olfml2b","protein_coding","chr13:82869433-82906607:+","gi|564381654|ref|XP_006250281.1|",3711,0,"PREDICTED: olfactomedin-like protein 2B isoform X1 [Rattus norvegicus]","gi|672074772|ref|XM_006250219.2|",3128,0,"PREDICTED: Rattus norvegicus olfactomedin-like 2B (Olfml2b), transcript variant X1, mRNA","Q3V1G4",1338,0,"Olfactomedin-like protein 2B",".",".",".",".","pfam02191","OLF","Olfactomedin-like domain.","GO:0030198|extracellular matrix organization;","GO:0031012|extracellular matrix;","GO:0042802|identical protein binding;GO:0050840|extracellular matrix binding;","K25449","OLFML2; olfactomedin-like protein 2"]
["ENSRNOG00000003276",450,28.94869718,1317,85.02796917,0.34046088,-1.554439058,{"v":3.4466e-99,"d":"3.45E-99"},{"v":2.01067E-98,"d":"2.01E-98"},"down","yes","Myo1d","protein_coding","chr10:65489154-65766349:-","gi|672068389|ref|XP_008766171.1|",5201,0,"PREDICTED: unconventional myosin-Id isoform X1 [Rattus norvegicus]","gi|672068388|ref|XM_008767949.1|",5033,0,"PREDICTED: Rattus norvegicus myosin ID (Myo1d), transcript variant X1, mRNA","Q63357",2006,0,"Unconventional myosin-Id","YMR109w",514,{"v":2E-155,"d":"2.00E-155"},"COG5022","pfam00063","Myosin_head","Myosin head (motor domain).","GO:0007015|actin filament organization;GO:0015031|protein transport;GO:0030050|vesicle transport along actin filament;GO:0030900|forebrain development;GO:0051641|cellular localization;GO:0061502|early endosome to recycling endosome transport;","GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005769|early endosome;GO:0005790|smooth endoplasmic reticulum;GO:0005886|plasma membrane;GO:0005902|microvillus;GO:0005903|brush border;GO:0005938|cell cortex;GO:0015629|actin cytoskeleton;GO:0016323|basolateral plasma membrane;GO:0016459|myosin complex;GO:0030424|axon;GO:0030673|axolemma;GO:0031410|cytoplasmic vesicle;GO:0031982|vesicle;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0043209|myelin sheath;GO:0044853|plasma membrane raft;GO:0097440|apical dendrite;","GO:0000146|microfilament motor activity;GO:0005516|calmodulin binding;GO:0005524|ATP binding;GO:0019904|protein domain specific binding;GO:0048306|calcium-dependent protein binding;GO:0051015|actin filament binding;","K10356","MYO1; myosin I"]
["ENSRNOG00000004688",1242,79.89840423,2519,162.6313245,0.491285455,-1.025366568,{"v":3.6017e-99,"d":"3.60E-99"},{"v":2.09903e-98,"d":"2.10E-98"},"down","yes","Rbfox2","protein_coding","chr7:108810628-109054691:-","gi|149066044|gb|EDM15917.1|",1238,{"v":1E-150,"d":"1.00E-150"},"RNA binding motif protein 9 (predicted), isoform CRA_b [Rattus norvegicus]","gi|20068520|emb|AL603843.15|",4286,0,"Mouse DNA sequence from clone RP23-412D17 on chromosome 15, complete sequence","A1A5R1",457,{"v":7e-142,"d":"7.00E-142"},"RNA binding protein fox-1 homolog 2","TP0356",50.4,7e-06,"COG0724","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0000380|alternative mRNA splicing, via spliceosome;GO:0000381|regulation of alternative mRNA splicing, via spliceosome;GO:0006397|mRNA processing;GO:0007399|nervous system development;GO:0008380|RNA splicing;GO:0010724|regulation of definitive erythrocyte differentiation;GO:0021942|radial glia guided migration of Purkinje cell;GO:0030520|intracellular estrogen receptor signaling pathway;GO:0043484|regulation of RNA splicing;GO:0045892|negative regulation of transcription, DNA-templated;GO:0048813|dendrite morphogenesis;GO:0050885|neuromuscular process controlling balance;GO:0061337|cardiac conduction;GO:0086091|regulation of heart rate by cardiac conduction;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0003714|transcription corepressor activity;GO:0003723|RNA binding;GO:0003729|mRNA binding;","K14946","RBFOX, FOX; RNA binding protein fox-1"]
["ENSRNOG00000020482",425,27.34043623,1274,82.2518092,0.332399208,-1.589011151,{"v":4.4928e-99,"d":"4.49E-99"},{"v":2.61569e-98,"d":"2.62E-98"},"down","yes","Nfatc4","protein_coding","chr15:29305535-29314610:+","gi|157822505|ref|NP_001100734.1|",3180,0,"nuclear factor of activated T-cells, cytoplasmic 4 [Rattus norvegicus]","gi|270047509|ref|NM_001168346.1|",3144,0,"Mus musculus nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 (Nfatc4), transcript variant 2, mRNA","Q8K120",1199,0,"Nuclear factor of activated T-cells, cytoplasmic 4",".",".",".",".","pfam00554","RHD","Rel homology domain (RHD). Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See pfam01833) that binds to DNA.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001569|branching involved in blood vessel morphogenesis;GO:0001816|cytokine production;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007507|heart development;GO:0007616|long-term memory;GO:0008630|intrinsic apoptotic signaling pathway in response to DNA damage;GO:0030178|negative regulation of Wnt signaling pathway;GO:0031547|brain-derived neurotrophic factor receptor signaling pathway;GO:0032091|negative regulation of protein binding;GO:0032760|positive regulation of tumor necrosis factor production;GO:0033173|calcineurin-NFAT signaling cascade;GO:0034644|cellular response to UV;GO:0035562|negative regulation of chromatin binding;GO:0043065|positive regulation of apoptotic process;GO:0043524|negative regulation of neuron apoptotic process;GO:0045333|cellular respiration;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048167|regulation of synaptic plasticity;GO:0050774|negative regulation of dendrite morphogenesis;GO:0051145|smooth muscle cell differentiation;GO:0055001|muscle cell development;GO:0060291|long-term synaptic potentiation;GO:0071285|cellular response to lithium ion;GO:1902894|negative regulation of pri-miRNA transcription by RNA polymerase II;GO:1904637|cellular response to ionomycin;GO:2000297|negative regulation of synapse maturation;GO:2001235|positive regulation of apoptotic signaling pathway;","GO:0005634|nucleus;GO:0005667|transcription factor complex;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016607|nuclear speck;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0008134|transcription factor binding;GO:0042975|peroxisome proliferator activated receptor binding;GO:1990837|sequence-specific double-stranded DNA binding;","K17334","NFATC4, NFAT3; nuclear factor of activated T-cells, cytoplasmic 4"]
["ENSRNOG00000008245",375,24.12391432,1187,76.63492741,0.314790072,-1.667538054,{"v":6.2535e-99,"d":"6.25E-99"},{"v":3.63701e-98,"d":"3.64E-98"},"down","yes","AABR07054614.1","protein_coding","chr3:155916412-155965451:-","gi|13928752|ref|NP_113745.1|",2482,0,"prostacyclin synthase precursor [Rattus norvegicus]","gi|42476132|ref|NM_031557.2|",1563,0,"Rattus norvegicus prostaglandin I2 (prostacyclin) synthase (Ptgis), mRNA","Q62969",960,0,"Prostacyclin synthase","YHR007c",78.6,{"v":4E-14,"d":"4.00E-14"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.",".",".",".",".","."]
["ENSRNOG00000004342",235,15.11765297,930,60.04252948,0.251782413,-1.989750579,{"v":1.05893E-98,"d":"1.06E-98"},{"v":6.15248e-98,"d":"6.15E-98"},"down","yes","Ahr","protein_coding","chr6:52234089-52271568:-","gi|815891117|ref|NP_001295183.1|",4105,0,"aryl hydrocarbon receptor isoform 2 [Rattus norvegicus]","gi|815891116|ref|NM_001308254.1|",5173,0,"Rattus norvegicus aryl hydrocarbon receptor (Ahr), transcript variant 2, mRNA","P41738",1566,0,"Aryl hydrocarbon receptor",".",".",".",".","pfam08447","PAS_3","PAS fold. The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0000902|cell morphogenesis;GO:0001541|ovarian follicle development;GO:0001568|blood vessel development;GO:0001569|branching involved in blood vessel morphogenesis;GO:0001782|B cell homeostasis;GO:0001889|liver development;GO:0001974|blood vessel remodeling;GO:0002260|lymphocyte homeostasis;GO:0002376|immune system process;GO:0002819|regulation of adaptive immune response;GO:0002841|negative regulation of T cell mediated immune response to tumor cell;GO:0003085|negative regulation of systemic arterial blood pressure;GO:0003214|cardiac left ventricle morphogenesis;GO:0003243|circumferential growth involved in left ventricle morphogenesis;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006366|transcription by RNA polymerase II;GO:0006805|xenobiotic metabolic process;GO:0006915|apoptotic process;GO:0008015|blood circulation;GO:0009410|response to xenobiotic stimulus;GO:0009636|response to toxic substance;GO:0010468|regulation of gene expression;GO:0010693|negative regulation of alkaline phosphatase activity;GO:0014070|response to organic cyclic compound;GO:0019933|cAMP-mediated signaling;GO:0030522|intracellular receptor signaling pathway;GO:0030850|prostate gland development;GO:0030888|regulation of B cell proliferation;GO:0032355|response to estradiol;GO:0032922|circadian regulation of gene expression;GO:0033689|negative regulation of osteoblast proliferation;GO:0035162|embryonic hemopoiesis;GO:0035166|post-embryonic hemopoiesis;GO:0040010|positive regulation of growth rate;GO:0043010|camera-type eye development;GO:0043029|T cell homeostasis;GO:0045668|negative regulation of osteoblast differentiation;GO:0045793|positive regulation of cell size;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045899|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly;GO:0045906|negative regulation of vasoconstriction;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048511|rhythmic process;GO:0048514|blood vessel morphogenesis;GO:0048536|spleen development;GO:0048608|reproductive structure development;GO:0048732|gland development;GO:0048745|smooth muscle tissue development;GO:0051726|regulation of cell cycle;GO:0060547|negative regulation of necrotic cell death;GO:0060841|venous blood vessel development;GO:0060993|kidney morphogenesis;GO:0061009|common bile duct development;GO:0071320|cellular response to cAMP;GO:0071385|cellular response to glucocorticoid stimulus;GO:0072102|glomerulus morphogenesis;GO:0097746|regulation of blood vessel diameter;GO:1903170|negative regulation of calcium ion transmembrane transport;GO:1904322|cellular response to forskolin;GO:1904613|cellular response to 2,3,7,8-tetrachlorodibenzodioxine;GO:1904682|cellular response to 3-methylcholanthrene;GO:2000279|negative regulation of DNA biosynthetic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0032991|protein-containing complex;GO:0034751|aryl hydrocarbon receptor complex;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987|proximal promoter sequence-specific DNA binding;GO:0001094|TFIID-class transcription factor complex binding;GO:0001223|transcription coactivator binding;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0004879|nuclear receptor activity;GO:0005515|protein binding;GO:0015643|toxic substance binding;GO:0017025|TBP-class protein binding;GO:0017162|aryl hydrocarbon receptor binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0043565|sequence-specific DNA binding;GO:0046982|protein heterodimerization activity;GO:0046983|protein dimerization activity;GO:0051087|chaperone binding;GO:0051879|Hsp90 protein binding;GO:0070888|E-box binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09093","AHR; aryl hydrocarbon receptor"]
["ENSRNOG00000010219",326,20.97172285,1098,70.8889219,0.295839213,-1.757114804,{"v":1.64448e-98,"d":"1.64E-98"},{"v":9.53519e-98,"d":"9.54E-98"},"down","yes","Ralgds","protein_coding","chr3:11839416-11880059:+","gi|37360320|dbj|BAC98138.1|",3773,0,"mKIAA1308 protein [Mus musculus]","gi|672044862|ref|XM_006233752.2|",3733,0,"PREDICTED: Rattus norvegicus ral guanine nucleotide dissociation stimulator (Ralgds), transcript variant X3, mRNA","Q03386",1389,0,"Ral guanine nucleotide dissociation stimulator",".",".",".",".","pfam00617","RasGEF","RasGEF domain. Guanine nucleotide exchange factor for Ras-like small GTPases.","GO:0007264|small GTPase mediated signal transduction;GO:0050790|regulation of catalytic activity;","GO:0005634|nucleus;GO:0005829|cytosol;GO:0005903|brush border;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0030695|GTPase regulator activity;","K08732","RALGDS; ral guanine nucleotide dissociation stimulator"]
["ENSRNOG00000033608",997,64.13744687,2161,139.5181787,0.459706738,-1.121214282,{"v":2.05318E-98,"d":"2.05E-98"},{"v":1.18808e-97,"d":"1.19E-97"},"down","yes","Cd276","protein_coding","chr8:58937751-58968380:-","gi|33414525|ref|NP_877976.1|",1470,0,"CD276 antigen precursor [Rattus norvegicus]","gi|71896575|ref|NM_182824.2|",2939,0,"Rattus norvegicus Cd276 molecule (Cd276), mRNA","Q7TPB4",570,0,"CD276 antigen",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.","GO:0001817|regulation of cytokine production;GO:0030501|positive regulation of bone mineralization;GO:0032689|negative regulation of interferon-gamma production;GO:0032703|negative regulation of interleukin-2 production;GO:0032729|positive regulation of interferon-gamma production;GO:0032743|positive regulation of interleukin-2 production;GO:0042102|positive regulation of T cell proliferation;GO:0042110|T cell activation;GO:0042130|negative regulation of T cell proliferation;GO:0045669|positive regulation of osteoblast differentiation;GO:0050728|negative regulation of inflammatory response;GO:0050776|regulation of immune response;GO:0050852|T cell receptor signaling pathway;","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0005102|signaling receptor binding;GO:0042802|identical protein binding;","K06746","B7H3, CD276; immune costimulatory protein B7-H3"]
["ENSRNOG00000002273",97,6.240052504,638,41.19046646,0.15149264,-2.722680391,{"v":2.38968e-98,"d":"2.39E-98"},{"v":1.3814E-97,"d":"1.38E-97"},"down","yes","Naaa","protein_coding","chr14:15777306-15796410:+","gi|58219537|ref|NP_001010967.1|",1870,0,"N-acylethanolamine-hydrolyzing acid amidase precursor [Rattus norvegicus]","gi|77736613|ref|NM_001010967.2|",1809,0,"Rattus norvegicus N-acylethanolamine acid amidase (Naaa), mRNA","Q5KTC7",721,0,"N-acylethanolamine-hydrolyzing acid amidase",".",".",".",".","pfam15508","NAAA-beta","beta subunit of N-acylethanolamine-hydrolyzing acid amidase. NAAA-beta is a family of vertebral sequences that form the beta subunit of vertebral N-acylethanolamine-hydrolyzing acid amidase, a member of the choloylglycine hydrolase acid ceramidase family. The alpha subunit is represented by family CBAH, pfam02275.","GO:0006631|fatty acid metabolic process;GO:0006670|sphingosine metabolic process;GO:0016042|lipid catabolic process;GO:0070291|N-acylethanolamine metabolic process;GO:0070292|N-acylphosphatidylethanolamine metabolic process;","GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0019898|extrinsic component of membrane;","GO:0016810|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;GO:0017040|N-acylsphingosine amidohydrolase activity;GO:0017064|fatty acid amide hydrolase activity;GO:0047412|N-(long-chain-acyl)ethanolamine deacylase activity;GO:0102121|ceramidase activity;","K13720","NAAA; N-(long-chain-acyl)ethanolamine deacylase [EC:3.5.1.60]"]
["ENSRNOG00000042980",651,41.87911526,1632,105.364955,0.397467216,-1.331092228,{"v":2.02511e-97,"d":"2.03E-97"},{"v":1.16476E-96,"d":"1.16E-96"},"down","yes","Adam19","protein_coding","chr10:30491405-30583105:+","gi|237681071|ref|NP_001153700.1|",4395,0,"disintegrin and metalloproteinase domain-containing protein 19 precursor [Rattus norvegicus]","gi|237681070|ref|NM_001160228.1|",6220,0,"Rattus norvegicus ADAM metallopeptidase domain 19 (Adam19), mRNA","O35674",1614,0,"Disintegrin and metalloproteinase domain-containing protein 19",".",".",".",".","pfam01421","Reprolysin","Reprolysin (M12B) family zinc metalloprotease. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as human ADAM8 and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.","GO:0001890|placenta development;GO:0006509|membrane protein ectodomain proteolysis;GO:0007507|heart development;GO:0008150|biological_process;GO:0010628|positive regulation of gene expression;GO:0016485|protein processing;GO:0042987|amyloid precursor protein catabolic process;GO:2000049|positive regulation of cell-cell adhesion mediated by cadherin;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0004222|metalloendopeptidase activity;GO:0017124|SH3 domain binding;GO:1902945|metalloendopeptidase activity involved in amyloid precursor protein catabolic process;","K08608","ADAM19; disintegrin and metalloproteinase domain-containing protein 19 [EC:3.4.24.-]"]
["ENSRNOG00000010666",1,0.064330438,509,32.86198656,1.957594E-3,-8.996702465,{"v":2.0976e-97,"d":"2.10E-97"},{"v":1.20524e-96,"d":"1.21E-96"},"down","yes","Ccn5","protein_coding","chr3:152491220-152502636:+","gi|149042986|gb|EDL96560.1|",1126,{"v":4e-148,"d":"4.00E-148"},"WNT1 inducible signaling pathway protein 2 [Rattus norvegicus]","gi|13928801|ref|NM_031590.1|",1630,0,"Rattus norvegicus WNT1 inducible signaling pathway protein 2 (Wisp2), mRNA","Q9Z0G4",423,{"v":7e-144,"d":"7.00E-144"},"WNT1-inducible-signaling pathway protein 2",".",".",".",".","pfam00219","IGFBP","Insulin-like growth factor binding protein.","GO:0001558|regulation of cell growth;GO:0007155|cell adhesion;GO:0007165|signal transduction;GO:0008285|negative regulation of cell proliferation;GO:0060548|negative regulation of cell death;","GO:0002102|podosome;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0031012|extracellular matrix;","GO:0005178|integrin binding;GO:0005515|protein binding;GO:0005520|insulin-like growth factor binding;GO:0008201|heparin binding;","K23089","CCN5, WISP2; CCN family member 5"]
["ENSRNOG00000018960",808,51.97899405,1870,120.7306776,0.430536754,-1.215791691,{"v":6.20233e-97,"d":"6.20E-97"},{"v":3.55657e-96,"d":"3.56E-96"},"down","yes","ENSRNOG00000018960","protein_coding","chr1:41512030-41983322:-","gi|672012705|ref|XP_008772548.1|",44114,0,"PREDICTED: nesprin-1 isoform X1 [Rattus norvegicus]","gi|672012704|ref|XM_008774326.1|",27488,0,"PREDICTED: Rattus norvegicus spectrin repeat containing, nuclear envelope 1 (Syne1), transcript variant X1, mRNA","Q6ZWR6",15530,0,"Nesprin-1","SPAC15A10.08",132,{"v":9e-30,"d":"9.00E-30"},"COG5069","pfam00307","CH","Calponin homology (CH) domain. The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.","GO:0002053|positive regulation of mesenchymal cell proliferation;GO:0007030|Golgi organization;GO:0007097|nuclear migration;GO:0007420|brain development;GO:0009416|response to light stimulus;GO:0042692|muscle cell differentiation;GO:0048260|positive regulation of receptor-mediated endocytosis;GO:0048814|regulation of dendrite morphogenesis;GO:0051642|centrosome localization;GO:0055007|cardiac muscle cell differentiation;GO:0061886|negative regulation of mini excitatory postsynaptic potential;GO:0090292|nuclear matrix anchoring at nuclear membrane;GO:0099149|regulation of postsynaptic neurotransmitter receptor internalization;GO:1902017|regulation of cilium assembly;GO:1903353|regulation of nucleus organization;GO:2001054|negative regulation of mesenchymal cell apoptotic process;","GO:0000932|P-body;GO:0005635|nuclear envelope;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005819|spindle;GO:0016021|integral component of membrane;GO:0030017|sarcomere;GO:0030496|midbody;GO:0031965|nuclear membrane;GO:0034993|meiotic nuclear membrane microtubule tethering complex;GO:0043197|dendritic spine;GO:0044327|dendritic spine head;GO:0045211|postsynaptic membrane;GO:0048471|perinuclear region of cytoplasm;","GO:0003779|actin binding;GO:0005102|signaling receptor binding;GO:0005198|structural molecule activity;GO:0005515|protein binding;GO:0005521|lamin binding;GO:0019899|enzyme binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0051015|actin filament binding;","K19326","SYNE1; nesprin-1"]
["ENSRNOG00000004489",629,40.46384562,1593,102.8470424,0.393437134,-1.345794964,{"v":1.00548e-96,"d":"1.01E-96"},{"v":5.74836e-96,"d":"5.75E-96"},"down","yes","Adgre5","protein_coding","chr19:24398689-24418638:+","gi|564394959|ref|XP_006255340.1|",4608,0,"PREDICTED: CD97 antigen isoform X1 [Rattus norvegicus]","gi|672084480|ref|XM_006255278.2|",3219,0,"PREDICTED: Rattus norvegicus CD97 molecule (Cd97), transcript variant X1, mRNA","Q9Z0M6",1303,0,"CD97 antigen",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0007166|cell surface receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0008150|biological_process;GO:0051965|positive regulation of synapse assembly;","GO:0005575|cellular_component;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;","GO:0003674|molecular_function;GO:0004930|G protein-coupled receptor activity;GO:0005509|calcium ion binding;","K08446","ADGRE5, CD97; CD97 antigen"]
["ENSRNOG00000019737",274,17.62654006,989,63.8516792,0.276054448,-1.856975247,{"v":8.71755e-96,"d":"8.72E-96"},{"v":4.97389e-95,"d":"4.97E-95"},"down","yes","Sema4a","protein_coding","chr2:173896439-173914442:-","gi|403224995|ref|NP_001012078.2|",3757,0,"semaphorin-4A precursor [Rattus norvegicus]","gi|403224994|ref|NM_001012078.2|",3147,0,"Rattus norvegicus semaphorin 4A (Sema4a), mRNA","Q62178",1378,0,"Semaphorin-4A",".",".",".",".","pfam01403","Sema","Sema domain. The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and human plexin A-3.","GO:0001755|neural crest cell migration;GO:0002292|T cell differentiation involved in immune response;GO:0007409|axonogenesis;GO:0007411|axon guidance;GO:0008360|regulation of cell shape;GO:0010594|regulation of endothelial cell migration;GO:0016525|negative regulation of angiogenesis;GO:0030335|positive regulation of cell migration;GO:0045063|T-helper 1 cell differentiation;GO:0048843|negative regulation of axon extension involved in axon guidance;GO:0050919|negative chemotaxis;GO:0071526|semaphorin-plexin signaling pathway;GO:1904891|positive regulation of excitatory synapse assembly;GO:1905704|positive regulation of inhibitory synapse assembly;","GO:0005615|extracellular space;GO:0005887|integral component of plasma membrane;","GO:0030215|semaphorin receptor binding;GO:0045499|chemorepellent activity;","K06521","SEMA4, CD100; semaphorin 4"]
["ENSRNOG00000016050",1117,71.85709945,2310,149.1378958,0.481816503,-1.053444285,{"v":3.85856e-95,"d":"3.86E-95"},{"v":2.1906e-94,"d":"2.19E-94"},"down","yes","Fgfr1","protein_coding","chr16:66494042-66547350:-","gi|674077166|ref|XP_008845991.1|",4419,0,"PREDICTED: fibroblast growth factor receptor 1 isoform X1 [Nannospalax galili]","gi|554790353|ref|NM_010206.3|",2673,0,"Mus musculus fibroblast growth factor receptor 1 (Fgfr1), transcript variant 1, mRNA","P16092",1594,0,"Fibroblast growth factor receptor 1",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001525|angiogenesis;GO:0001657|ureteric bud development;GO:0001701|in utero embryonic development;GO:0001759|organ induction;GO:0001837|epithelial to mesenchymal transition;GO:0002053|positive regulation of mesenchymal cell proliferation;GO:0002062|chondrocyte differentiation;GO:0002931|response to ischemia;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007275|multicellular organism development;GO:0007420|brain development;GO:0007435|salivary gland morphogenesis;GO:0007565|female pregnancy;GO:0007605|sensory perception of sound;GO:0008284|positive regulation of cell proliferation;GO:0008543|fibroblast growth factor receptor signaling pathway;GO:0010468|regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010763|positive regulation of fibroblast migration;GO:0010863|positive regulation of phospholipase C activity;GO:0010966|regulation of phosphate transport;GO:0010976|positive regulation of neuron projection development;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0019827|stem cell population maintenance;GO:0021769|orbitofrontal cortex development;GO:0021837|motogenic signaling involved in postnatal olfactory bulb interneuron migration;GO:0021847|ventricular zone neuroblast division;GO:0021954|central nervous system neuron development;GO:0030324|lung development;GO:0030326|embryonic limb morphogenesis;GO:0030901|midbrain development;GO:0031175|neuron projection development;GO:0031667|response to nutrient levels;GO:0033674|positive regulation of kinase activity;GO:0035607|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development;GO:0042060|wound healing;GO:0042127|regulation of cell proliferation;GO:0042472|inner ear morphogenesis;GO:0042473|outer ear morphogenesis;GO:0042474|middle ear morphogenesis;GO:0043406|positive regulation of MAP kinase activity;GO:0043410|positive regulation of MAPK cascade;GO:0043536|positive regulation of blood vessel endothelial cell migration;GO:0043583|ear development;GO:0045597|positive regulation of cell differentiation;GO:0045666|positive regulation of neuron differentiation;GO:0045668|negative regulation of osteoblast differentiation;GO:0045787|positive regulation of cell cycle;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046777|protein autophosphorylation;GO:0048339|paraxial mesoderm development;GO:0048378|regulation of lateral mesodermal cell fate specification;GO:0048469|cell maturation;GO:0048514|blood vessel morphogenesis;GO:0048699|generation of neurons;GO:0048762|mesenchymal cell differentiation;GO:0050729|positive regulation of inflammatory response;GO:0051174|regulation of phosphorus metabolic process;GO:0051897|positive regulation of protein kinase B signaling;GO:0051930|regulation of sensory perception of pain;GO:0060045|positive regulation of cardiac muscle cell proliferation;GO:0060117|auditory receptor cell development;GO:0060445|branching involved in salivary gland morphogenesis;GO:0060484|lung-associated mesenchyme development;GO:0060665|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling;GO:0070640|vitamin D3 metabolic process;GO:0071222|cellular response to lipopolysaccharide;GO:0071420|cellular response to histamine;GO:0072091|regulation of stem cell proliferation;GO:0090080|positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway;GO:0090272|negative regulation of fibroblast growth factor production;GO:1903465|positive regulation of mitotic cell cycle DNA replication;GO:1905564|positive regulation of vascular endothelial cell proliferation;GO:1990090|cellular response to nerve growth factor stimulus;GO:2000491|positive regulation of hepatic stellate cell activation;GO:2000546|positive regulation of endothelial cell chemotaxis to fibroblast growth factor;GO:2000830|positive regulation of parathyroid hormone secretion;GO:2001239|regulation of extrinsic apoptotic signaling pathway in absence of ligand;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;GO:0031410|cytoplasmic vesicle;GO:0043235|receptor complex;GO:0048471|perinuclear region of cytoplasm;","GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0005007|fibroblast growth factor-activated receptor activity;GO:0005102|signaling receptor binding;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0008201|heparin binding;GO:0017134|fibroblast growth factor binding;GO:0042169|SH2 domain binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0044877|protein-containing complex binding;GO:0050839|cell adhesion molecule binding;GO:0090722|receptor-receptor interaction;","K04362","FGFR1, CD331; fibroblast growth factor receptor 1 [EC:2.7.10.1]"]
["ENSRNOG00000004613",192,12.35144413,827,53.39265793,0.231332258,-2.111961638,{"v":7.37995e-95,"d":"7.38E-95"},{"v":4.17319e-94,"d":"4.17E-94"},"down","yes","Gpm6b","protein_coding","chrX:28059450-28204211:-","gi|295789070|ref|NP_001171427.1|",1631,0,"neuronal membrane glycoprotein M6-b isoform 2 [Mus musculus]","gi|672087294|ref|XM_006256850.2|",2456,0,"PREDICTED: Rattus norvegicus glycoprotein m6b (Gpm6b), transcript variant X2, mRNA","P35803",592,0,"Neuronal membrane glycoprotein M6-b",".",".",".",".","pfam01275","Myelin_PLP","Myelin proteolipid protein (PLP or lipophilin).","GO:0001503|ossification;GO:0015031|protein transport;GO:0030501|positive regulation of bone mineralization;GO:0031175|neuron projection development;GO:0032956|regulation of actin cytoskeleton organization;GO:0051612|negative regulation of serotonin uptake;GO:0051893|regulation of focal adhesion assembly;GO:0085029|extracellular matrix assembly;GO:2000009|negative regulation of protein localization to cell surface;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0045121|membrane raft;",".",".","."]
["ENSRNOG00000011321",260,16.72591393,958,61.85026155,0.270425921,-1.886694652,{"v":8.14382e-95,"d":"8.14E-95"},{"v":4.60058e-94,"d":"4.60E-94"},"down","yes","Rftn1","protein_coding","chr9:10804611-11002084:+","gi|202070751|ref|NP_001128483.1|",2874,0,"raft-linking protein [Rattus norvegicus]","gi|202070750|ref|NM_001135011.1|",2826,0,"Rattus norvegicus raftlin lipid raft linker 1 (Rftn1), mRNA","Q6A0D4",998,0,"Raftlin",".",".",".",".","pfam15250","Raftlin","Raftlin. This family of proteins plays a role in the formation and/or maintenance of lipid rafts.","GO:0001765|membrane raft assembly;GO:0002457|T cell antigen processing and presentation;GO:0032596|protein transport into membrane raft;GO:0032740|positive regulation of interleukin-17 production;GO:0033227|dsRNA transport;GO:0034138|toll-like receptor 3 signaling pathway;GO:0040010|positive regulation of growth rate;GO:0043330|response to exogenous dsRNA;GO:0050852|T cell receptor signaling pathway;GO:0050853|B cell receptor signaling pathway;GO:1903044|protein localization to membrane raft;","GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005886|plasma membrane;GO:0032991|protein-containing complex;GO:0045121|membrane raft;","GO:0003725|double-stranded RNA binding;",".","."]
["ENSRNOG00000012645",141,9.070591784,720,46.48453895,0.19513137,-2.357482363,{"v":1.62503e-94,"d":"1.63E-94"},{"v":9.17097e-94,"d":"9.17E-94"},"down","yes","Mecom","protein_coding","chr2:112909321-113464590:+","gi|564336156|ref|XP_006232311.1|",5249,0,"PREDICTED: MDS1 and EVI1 complex locus protein EVI1 isoform X1 [Rattus norvegicus]","gi|672042051|ref|XM_006232250.2|",3995,0,"PREDICTED: Rattus norvegicus MDS1 and EVI1 complex locus (Mecom), transcript variant X5, mRNA","P14404",1954,0,"MDS1 and EVI1 complex locus protein",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0001701|in utero embryonic development;GO:0001780|neutrophil homeostasis;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006954|inflammatory response;GO:0009617|response to bacterium;GO:0009791|post-embryonic development;GO:0030900|forebrain development;GO:0035115|embryonic forelimb morphogenesis;GO:0035116|embryonic hindlimb morphogenesis;GO:0042127|regulation of cell proliferation;GO:0043069|negative regulation of programmed cell death;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046329|negative regulation of JNK cascade;GO:0051567|histone H3-K9 methylation;GO:0051726|regulation of cell cycle;GO:0060039|pericardium development;GO:0070828|heterochromatin organization;GO:0071425|hematopoietic stem cell proliferation;GO:0072197|ureter morphogenesis;GO:0090336|positive regulation of brown fat cell differentiation;GO:0098727|maintenance of cell number;","GO:0000118|histone deacetylase complex;GO:0005634|nucleus;GO:0016607|nuclear speck;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0042803|protein homodimerization activity;GO:0046974|histone methyltransferase activity (H3-K9 specific);","K04462","MECOM, EVI1, PRDM3; [histone H3]-lysine9 N-methyltransferase (ecotropic virus integration site 1 protein) [EC:2.1.1.367]"]
["ENSRNOG00000020867",388,24.96021002,1185,76.50580369,0.326252504,-1.615939121,{"v":1.65531e-94,"d":"1.66E-94"},{"v":9.33269e-94,"d":"9.33E-94"},"down","yes","Numbl","protein_coding","chr1:82550054-82573776:+","gi|564326908|ref|XP_006228627.1|",2581,0,"PREDICTED: numb-like protein isoform X1 [Rattus norvegicus]","gi|672035606|ref|XM_006228565.2|",3803,0,"PREDICTED: Rattus norvegicus numb homolog (Drosophila)-like (Numbl), transcript variant X1, mRNA","A1L1I3",931,0,"Numb-like protein",".",".",".",".","pfam06311","NumbF","NUMB domain. This presumed domain is found in the Numb family of proteins adjacent to the PTB domain..","GO:0007399|nervous system development;GO:0007405|neuroblast proliferation;GO:0007409|axonogenesis;GO:0019221|cytokine-mediated signaling pathway;GO:0019538|protein metabolic process;GO:0021670|lateral ventricle development;GO:0021849|neuroblast division in subventricular zone;GO:0030900|forebrain development;GO:0034332|adherens junction organization;GO:0050769|positive regulation of neurogenesis;GO:0050775|positive regulation of dendrite morphogenesis;","GO:0005575|cellular_component;GO:0005737|cytoplasm;","GO:0005515|protein binding;","K06057","NUMBL; numb"]
["ENSRNOG00000045558",807,51.91466362,1850,119.4394404,0.434652603,-1.202065311,{"v":3.02654e-94,"d":"3.03E-94"},{"v":1.70133e-93,"d":"1.70E-93"},"down","yes","Cd34","protein_coding","chr13:106480043-106499832:+","gi|157821377|ref|NP_001100672.1|",1562,0,"hematopoietic progenitor cell antigen CD34 precursor [Rattus norvegicus]","gi|672075154|ref|XM_008769857.1|",1266,0,"PREDICTED: Rattus norvegicus CD34 molecule (Cd34), transcript variant X1, mRNA","Q64314",495,{"v":1E-169,"d":"1.00E-169"},"Hematopoietic progenitor cell antigen CD34",".",".",".",".","pfam06365","CD34_antigen","CD34/Podocalyxin family. This family consists of several mammalian CD34 antigen proteins. The CD34 antigen is a human leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. CD34 is a phosphoprotein. Activation of protein kinase C (PKC) has been found to enhance CD34 phosphorylation. This family contains several eukaryotic podocalyxin proteins. Podocalyxin is a major membrane protein of the glomerular epithelium and is thought to be involved in maintenance of the architecture of the foot processes and filtration slits characteristic of this unique epithelium by virtue of its high negative charge. Podocalyxin functions as an anti-adhesin that maintains an open filtration pathway between neighbouring foot processes in the glomerular epithelium by charge repulsion.","GO:0001894|tissue homeostasis;GO:0001935|endothelial cell proliferation;GO:0003094|glomerular filtration;GO:0003158|endothelium development;GO:0007160|cell-matrix adhesion;GO:0007165|signal transduction;GO:0008217|regulation of blood pressure;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0030097|hemopoiesis;GO:0030195|negative regulation of blood coagulation;GO:0032703|negative regulation of interleukin-2 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032733|positive regulation of interleukin-10 production;GO:0035759|mesangial cell-matrix adhesion;GO:0038001|paracrine signaling;GO:0042482|positive regulation of odontogenesis;GO:0045019|negative regulation of nitric oxide biosynthetic process;GO:0045766|positive regulation of angiogenesis;GO:0048870|cell motility;GO:0050900|leukocyte migration;GO:0060290|transdifferentiation;GO:0061042|vascular wound healing;GO:0071425|hematopoietic stem cell proliferation;GO:0071636|positive regulation of transforming growth factor beta production;GO:0071657|positive regulation of granulocyte colony-stimulating factor production;GO:0071971|extracellular exosome assembly;GO:0072011|glomerular endothelium development;GO:0072089|stem cell proliferation;GO:0072254|metanephric glomerular mesangial cell differentiation;GO:0098609|cell-cell adhesion;GO:1900035|negative regulation of cellular response to heat;GO:1900038|negative regulation of cellular response to hypoxia;GO:1900168|positive regulation of glial cell-derived neurotrophic factor secretion;GO:1901215|negative regulation of neuron death;GO:2001214|positive regulation of vasculogenesis;","GO:0005576|extracellular region;GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009925|basal plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0036053|glomerular endothelium fenestra;GO:0045171|intercellular bridge;GO:0048471|perinuclear region of cytoplasm;GO:0071944|cell periphery;","GO:0030246|carbohydrate binding;GO:0043199|sulfate binding;","K06474","CD34; CD34 antigen"]
["ENSRNOG00000010718",173,11.12916581,781,50.42281239,0.220716879,-2.17973113,{"v":3.05383e-93,"d":"3.05E-93"},{"v":1.70826e-92,"d":"1.71E-92"},"down","yes","Gpr153","protein_coding","chr5:162781587-162792971:+","gi|564354291|ref|XP_006239548.1|",2621,0,"PREDICTED: probable G-protein coupled receptor 153 isoform X2 [Rattus norvegicus]","gi|672055030|ref|XM_006239486.2|",3916,0,"PREDICTED: Rattus norvegicus G protein-coupled receptor 153 (Gpr153), transcript variant X2, mRNA","Q8K0Z9",973,0,"Probable G-protein coupled receptor 153",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;","GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;","K08437","GPR153; G protein-coupled receptor 153"]
["ENSRNOG00000068909",2,0.128660876,424,27.37422849,0.004700073,-7.733101074,{"v":5.61194e-93,"d":"5.61E-93"},{"v":3.13309e-92,"d":"3.13E-92"},"down","yes","Cyp11b1","protein_coding","chr7:106718274-106779278:-","gi|303794|dbj|BAA00988.1|",2467,0,"cytochrome P-450-11beta [Rattus norvegicus]","gi|672059626|ref|XM_003750363.3|",1514,0,"PREDICTED: Rattus norvegicus cytochrome P450 11B1, mitochondrial-like (LOC100910462), transcript variant X1, mRNA","P15393",950,0,"Cytochrome P450 11B1, mitochondrial","alr4833",86.7,{"v":8e-17,"d":"8.00E-17"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.",".",".",".",".","."]
["ENSRNOG00000011334",25,1.608260955,428,27.63247593,0.05820184,-4.102791416,{"v":5.75586e-93,"d":"5.76E-93"},{"v":3.2103E-92,"d":"3.21E-92"},"down","yes","Tmem63c","protein_coding","chr6:106672934-106736990:+","gi|157820653|ref|NP_001101515.1|",4016,0,"calcium permeable stress-gated cation channel 1 [Rattus norvegicus]","gi|157820652|ref|NM_001108045.1|",3604,0,"Rattus norvegicus transmembrane protein 63c (Tmem63c), mRNA","Q8CBX0",1454,0,"Calcium permeable stress-gated cation channel 1","SPAC24H6.13",55.5,1e-06,"COG5594","pfam02714","DUF221","Domain of unknown function DUF221. This family consists of hypothetical transmembrane proteins none of which have any function, the aligned region is at 538 residues at maximum length.","GO:0003094|glomerular filtration;GO:0006812|cation transport;GO:0098655|cation transmembrane transport;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0005227|calcium activated cation channel activity;GO:1990760|osmolarity-sensing cation channel activity;","K21989","TMEM63, CSC1; calcium permeable stress-gated cation channel"]
["ENSRNOG00000008586",66,4.24580892,537,34.66971863,0.122464476,-3.029564778,{"v":2.853e-92,"d":"2.85E-92"},{"v":1.5866E-91,"d":"1.59E-91"},"down","yes","Aldh1l2","protein_coding","chr7:20254233-20305776:+","gi|300796253|ref|NP_001178707.1|",4784,0,"probable 10-formyltetrahydrofolate dehydrogenase ALDH1L2 [Rattus norvegicus]","gi|283436217|ref|NM_153543.2|",2630,0,"Mus musculus aldehyde dehydrogenase 1 family, member L2 (Aldh1l2), mRNA","Q8K009",1835,0,"Mitochondrial 10-formyltetrahydrofolate dehydrogenase","BS_dhaS",429,{"v":6e-136,"d":"6.00E-136"},"COG1012","pfam00171","Aldedh","Aldehyde dehydrogenase family. This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:1.2.1.3. Succinate-semialdehyde dehydrogenase EC:1.2.1.16. Lactaldehyde dehydrogenase EC:1.2.1.22. Benzaldehyde dehydrogenase EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase EC: 1.5.1.12. Acetaldehyde dehydrogenase EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase EC:1.2.1.41. This family also includes omega crystallin, an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.","GO:0006730|one-carbon metabolic process;GO:0009058|biosynthetic process;GO:0009258|10-formyltetrahydrofolate catabolic process;","GO:0005654|nucleoplasm;GO:0005739|mitochondrion;GO:0016021|integral component of membrane;","GO:0004029|aldehyde dehydrogenase (NAD) activity;GO:0016155|formyltetrahydrofolate dehydrogenase activity;GO:0016742|hydroxymethyl-, formyl- and related transferase activity;","K00289","ALDH1L; formyltetrahydrofolate dehydrogenase [EC:1.5.1.6]"]
["ENSRNOG00000033940",610,39.24156729,1534,99.03789271,0.39622781,-1.335597954,{"v":3.74577e-92,"d":"3.75E-92"},{"v":2.07903e-91,"d":"2.08E-91"},"down","yes","Adgrl4","protein_coding","chr2:240354941-240457225:+","gi|11225481|gb|AAG33020.1|",3349,0,"ETL protein [Rattus norvegicus]","gi|11225480|gb|AF192402.1|AF192402",4443,0,"Rattus norvegicus ETL protein mRNA, alternatively spliced isoform, complete cds","Q9ESC1",1233,0,"Adhesion G protein-coupled receptor L4",".",".",".",".","pfam12003","DUF3497","Domain of unknown function (DUF3497). This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 213 to 257 amino acids in length. This domain is found associated with pfam02793, pfam00002, pfam01825. This domain has a single completely conserved residue W that may be functionally important.","GO:0007166|cell surface receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0065003|protein-containing complex assembly;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0031410|cytoplasmic vesicle;","GO:0004930|G protein-coupled receptor activity;GO:0005509|calcium ion binding;","K04595","ADGRL4, ELTD1; adhesion G protein-coupled receptor L4"]
["ENSRNOG00000009195",1011,65.038073,2135,137.8395704,0.471838913,-1.083633692,{"v":3.88357e-92,"d":"3.88E-92"},{"v":2.15343e-91,"d":"2.15E-91"},"down","yes","Tnks1bp1","protein_coding","chr3:70137837-70160038:+","gi|109470195|ref|XP_001069984.1|",7566,0,"PREDICTED: 182 kDa tankyrase-1-binding protein [Rattus norvegicus]","gi|672017038|ref|XM_006224505.2|",5633,0,"PREDICTED: Rattus norvegicus tankyrase 1 binding protein 1 (Tnks1bp1), transcript variant X1, mRNA","P58871",2538,0,"182 kDa tankyrase-1-binding protein",".",".",".",".","pfam15327","Tankyrase_bdg_C","Tankyrase binding protein C terminal domain. This protein domain family is found at the C-terminal end of the Tankyrase binding protein in eukaryotes. The precise function of this protein is still unknown. However, it is known interacts with the enzyme tankyrase, a telomeric poly(ADP-ribose) polymerase, by binding to it. Tankyrin catalyses poly(ADP-ribose) chain formation onto proteins. More specifically, it binds to the ankyrin domain in tankyrase. The protein domain is approximately 170 amino acids in length and contains two conserved sequence motifs: FPG and LKA.","GO:0006302|double-strand break repair;GO:0010800|positive regulation of peptidyl-threonine phosphorylation;GO:0031954|positive regulation of protein autophosphorylation;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0071479|cellular response to ionizing radiation;","GO:0000792|heterochromatin;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005912|adherens junction;GO:0015629|actin cytoskeleton;GO:0030014|CCR4-NOT complex;","GO:0019899|enzyme binding;GO:0044877|protein-containing complex binding;GO:0071532|ankyrin repeat binding;",".","."]
["ENSRNOG00000017226",77,4.95344374,561,36.21920327,0.136762913,-2.870251039,{"v":1.87878e-91,"d":"1.88E-91"},{"v":1.03574e-90,"d":"1.04E-90"},"down","yes","Slc2a4","protein_coding","chr10:54666015-54671565:-","gi|6980958|ref|NP_036883.1|",2198,0,"solute carrier family 2, facilitated glucose transporter member 4 [Rattus norvegicus]","gi|55250154|gb|BC085757.1|",2543,0,"Rattus norvegicus solute carrier family 2 (facilitated glucose transporter), member 4, mRNA (cDNA clone MGC:93607 IMAGE:7192278), complete cds","P19357",851,0,"Solute carrier family 2, facilitated glucose transporter member 4","YBR241c",165,{"v":1E-42,"d":"1.00E-42"},"COG0477","pfam00083","Sugar_tr","Sugar (and other) transporter.","GO:0007611|learning or memory;GO:0007614|short-term memory;GO:0007616|long-term memory;GO:0010021|amylopectin biosynthetic process;GO:0031550|positive regulation of brain-derived neurotrophic factor receptor signaling pathway;GO:0032869|cellular response to insulin stimulus;GO:0042593|glucose homeostasis;GO:0044381|glucose import in response to insulin stimulus;GO:0045471|response to ethanol;GO:0046323|glucose import;GO:0050873|brown fat cell differentiation;GO:0071356|cellular response to tumor necrosis factor;GO:0071456|cellular response to hypoxia;GO:0071470|cellular response to osmotic stress;GO:0098694|regulation of synaptic vesicle budding from presynaptic endocytic zone membrane;GO:1904659|glucose transmembrane transport;","GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005771|multivesicular body;GO:0005802|trans-Golgi network;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005905|clathrin-coated pit;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0012505|endomembrane system;GO:0012506|vesicle membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016529|sarcoplasmic reticulum;GO:0030136|clathrin-coated vesicle;GO:0030140|trans-Golgi network transport vesicle;GO:0030315|T-tubule;GO:0030659|cytoplasmic vesicle membrane;GO:0031982|vesicle;GO:0032593|insulin-responsive compartment;GO:0042383|sarcolemma;GO:0043231|intracellular membrane-bounded organelle;GO:0045121|membrane raft;GO:0048471|perinuclear region of cytoplasm;GO:0070062|extracellular exosome;GO:0098793|presynapse;","GO:0005355|glucose transmembrane transporter activity;GO:0005515|protein binding;GO:0055056|D-glucose transmembrane transporter activity;","K07191","SLC2A4, GLUT4; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 4"]
["ENSRNOG00000014837",47,3.023530595,482,31.11881635,0.097160848,-3.363481104,{"v":5.90124e-91,"d":"5.90E-91"},{"v":3.23764e-90,"d":"3.24E-90"},"down","yes","Emilin2","protein_coding","chr9:111160712-111220352:-","gi|672066409|ref|XP_008765663.1|",5182,0,"PREDICTED: EMILIN-2 isoform X2 [Rattus norvegicus]","gi|672024432|ref|XM_006226977.2|",3079,0,"PREDICTED: Rattus norvegicus elastin microfibril interfacer 2 (Emilin2), transcript variant X1, mRNA","Q8K482",1878,0,"EMILIN-2",".",".",".",".","pfam07546","EMI","EMI domain. The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.",".","GO:0005576|extracellular region;",".","K24246","EMILIN; emilin"]
["ENSRNOG00000065917",0,0.032165219,552,35.63814653,0.00090255,-10.11370508,{"v":8.93286e-91,"d":"8.93E-91"},{"v":4.8915e-90,"d":"4.89E-90"},"down","yes","ENSRNOG00000065917","protein_coding","chr6:132469837-132473735:-","gi|121056|sp|P20762.1|IGG2C_RAT",1488,0,"RecName: Full=Ig gamma-2C chain C region","gi|71051337|gb|BC098733.1|",1088,0,"Rattus norvegicus immunoglobulin G heavy chain, mRNA (cDNA clone IMAGE:7385053)","P20762",577,0,"Ig gamma-2C chain C region",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.",".",".",".",".","."]
["ENSRNOG00000036829",199,12.8017572,819,52.87616306,0.242108286,-2.04627564,{"v":2.59262e-90,"d":"2.59E-90"},{"v":1.41561E-89,"d":"1.42E-89"},"down","yes","Nckap1l","protein_coding","chr7:134577482-134622934:+","gi|672060100|ref|XP_008763975.1|",6060,0,"PREDICTED: nck-associated protein 1-like isoform X1 [Rattus norvegicus]","gi|672060099|ref|XM_008765753.1|",4650,0,"PREDICTED: Rattus norvegicus NCK associated protein 1 like (Nckap1l), transcript variant X1, mRNA","Q8K1X4",2302,0,"Nck-associated protein 1-like",".",".",".",".","pfam09735","Nckap1","Membrane-associated apoptosis protein. Expression of this protein was found to be markedly reduced in patients with Alzheimer's disease. It is involved in the regulation of actin polymerization in the brain as part of a WAVE2 signalling complex.","GO:0000902|cell morphogenesis;GO:0001782|B cell homeostasis;GO:0002262|myeloid cell homeostasis;GO:0002687|positive regulation of leukocyte migration;GO:0006935|chemotaxis;GO:0009410|response to xenobiotic stimulus;GO:0016477|cell migration;GO:0030011|maintenance of cell polarity;GO:0030031|cell projection assembly;GO:0030593|neutrophil chemotaxis;GO:0030838|positive regulation of actin filament polymerization;GO:0030866|cortical actin cytoskeleton organization;GO:0030890|positive regulation of B cell proliferation;GO:0032147|activation of protein kinase activity;GO:0032700|negative regulation of interleukin-17 production;GO:0032715|negative regulation of interleukin-6 production;GO:0033630|positive regulation of cell adhesion mediated by integrin;GO:0034101|erythrocyte homeostasis;GO:0035509|negative regulation of myosin-light-chain-phosphatase activity;GO:0042102|positive regulation of T cell proliferation;GO:0042327|positive regulation of phosphorylation;GO:0043029|T cell homeostasis;GO:0043066|negative regulation of apoptotic process;GO:0043318|negative regulation of cytotoxic T cell degranulation;GO:0043372|positive regulation of CD4-positive, alpha-beta T cell differentiation;GO:0043378|positive regulation of CD8-positive, alpha-beta T cell differentiation;GO:0045579|positive regulation of B cell differentiation;GO:0045588|positive regulation of gamma-delta T cell differentiation;GO:0045621|positive regulation of lymphocyte differentiation;GO:0045648|positive regulation of erythrocyte differentiation;GO:0048812|neuron projection morphogenesis;GO:0048821|erythrocyte development;GO:0050853|B cell receptor signaling pathway;GO:0060100|positive regulation of phagocytosis, engulfment;GO:0065003|protein-containing complex assembly;GO:0070358|actin polymerization-dependent cell motility;GO:0090023|positive regulation of neutrophil chemotaxis;GO:1902624|positive regulation of neutrophil migration;GO:1904515|positive regulation of TORC2 signaling;","GO:0005829|cytosol;GO:0031209|SCAR complex;","GO:0005096|GTPase activator activity;GO:0030295|protein kinase activator activity;GO:0044877|protein-containing complex binding;GO:1904841|TORC2 complex binding;","K05750","NCKAP1, NAP125; NCK-associated protein 1"]
["ENSRNOG00000007090",134,8.620278717,686,44.28943572,0.194635099,-2.361156195,{"v":2.63634e-90,"d":"2.64E-90"},{"v":1.4381e-89,"d":"1.44E-89"},"down","yes","Cacna1c","protein_coding","chr4:151764138-152379648:-","gi|564348506|ref|XP_006237221.1|",8555,0,"PREDICTED: voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [Rattus norvegicus]","gi|672050773|ref|XM_006237170.2|",5066,0,"PREDICTED: Rattus norvegicus calcium channel, voltage-dependent, L type, alpha 1C subunit (Cacna1c), transcript variant X2, mRNA","P22002",3189,0,"Voltage-dependent L-type calcium channel subunit alpha-1C",".",".",".",".","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0002520|immune system development;GO:0006816|calcium ion transport;GO:0006874|cellular calcium ion homeostasis;GO:0006939|smooth muscle contraction;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007268|chemical synaptic transmission;GO:0007507|heart development;GO:0007628|adult walking behavior;GO:0008217|regulation of blood pressure;GO:0008542|visual learning;GO:0010881|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;GO:0017156|calcium ion regulated exocytosis;GO:0019229|regulation of vasoconstriction;GO:0030073|insulin secretion;GO:0030252|growth hormone secretion;GO:0034765|regulation of ion transmembrane transport;GO:0035115|embryonic forelimb morphogenesis;GO:0042593|glucose homeostasis;GO:0043010|camera-type eye development;GO:0045762|positive regulation of adenylate cyclase activity;GO:0046620|regulation of organ growth;GO:0060078|regulation of postsynaptic membrane potential;GO:0060083|smooth muscle contraction involved in micturition;GO:0060402|calcium ion transport into cytosol;GO:0061337|cardiac conduction;GO:0061577|calcium ion transmembrane transport via high voltage-gated calcium channel;GO:0070509|calcium ion import;GO:0070588|calcium ion transmembrane transport;GO:0086002|cardiac muscle cell action potential involved in contraction;GO:0086012|membrane depolarization during cardiac muscle cell action potential;GO:0086045|membrane depolarization during AV node cell action potential;GO:0086065|cell communication involved in cardiac conduction;GO:0086091|regulation of heart rate by cardiac conduction;GO:0098703|calcium ion import across plasma membrane;GO:0098911|regulation of ventricular cardiac muscle cell action potential;GO:0098912|membrane depolarization during atrial cardiac muscle cell action potential;GO:1904646|cellular response to amyloid-beta;GO:1904879|positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel;","GO:0002095|caveolar macromolecular signaling complex;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005891|voltage-gated calcium channel complex;GO:0009986|cell surface;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0030018|Z disc;GO:0030315|T-tubule;GO:0030425|dendrite;GO:0032991|protein-containing complex;GO:0042383|sarcolemma;GO:0042734|presynaptic membrane;GO:0043025|neuronal cell body;GO:0043198|dendritic shaft;GO:0043204|perikaryon;GO:0044306|neuron projection terminus;GO:0045211|postsynaptic membrane;GO:0090712|basal pole of outer hair cell;GO:0098839|postsynaptic density membrane;GO:0098978|glutamatergic synapse;GO:0099055|integral component of postsynaptic membrane;GO:0099056|integral component of presynaptic membrane;GO:1904115|axon cytoplasm;GO:1990454|L-type voltage-gated calcium channel complex;","GO:0005245|voltage-gated calcium channel activity;GO:0005515|protein binding;GO:0005516|calmodulin binding;GO:0008331|high voltage-gated calcium channel activity;GO:0019899|enzyme binding;GO:0019904|protein domain specific binding;GO:0031369|translation initiation factor binding;GO:0044325|ion channel binding;GO:0046872|metal ion binding;GO:0051393|alpha-actinin binding;GO:0051721|protein phosphatase 2A binding;GO:0086007|voltage-gated calcium channel activity involved in cardiac muscle cell action potential;GO:0086056|voltage-gated calcium channel activity involved in AV node cell action potential;GO:1905030|voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K04850","CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C"]
["ENSRNOG00000028274",252,16.21127042,919,59.33234902,0.273228192,-1.871821747,{"v":4.35408e-90,"d":"4.35E-90"},{"v":2.36834e-89,"d":"2.37E-89"},"down","yes","Myrf","protein_coding","chr1:206854175-206886157:-","gi|282165688|ref|NP_001163958.1|",5071,0,"myelin regulatory factor [Rattus norvegicus]","gi|672039689|ref|XM_006231030.2|",5575,0,"PREDICTED: Rattus norvegicus myelin regulatory factor (Myrf), transcript variant X1, mRNA","Q3UR85",1899,0,"Myelin regulatory factor",".",".",".",".","pfam13888","MRF_C2","Myelin gene regulatory factor C-terminal domain 2. This domain is found further downstream of Peptidase_S74, pfam13884, and MRF_C1, pfam13887. The function is not known.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0014003|oligodendrocyte development;GO:0016540|protein autoprocessing;GO:0022010|central nervous system myelination;GO:0031643|positive regulation of myelination;GO:0032286|central nervous system myelin maintenance;GO:0045893|positive regulation of transcription, DNA-templated;GO:0048709|oligodendrocyte differentiation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005789|endoplasmic reticulum membrane;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0016021|integral component of membrane;","GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0042802|identical protein binding;GO:0043565|sequence-specific DNA binding;","K24768","MYRF; myelin regulatory factor [EC:3.4.-.-]"]
["ENSRNOG00000020030",20,1.286608764,399,25.760182,0.049945639,-4.323497461,{"v":3.11006e-89,"d":"3.11E-89"},{"v":1.68365E-88,"d":"1.68E-88"},"down","yes","Crlf1","protein_coding","chr16:18924722-18935997:-","gi|564388516|ref|XP_006252934.1|",1655,0,"PREDICTED: cytokine receptor-like factor 1 isoform X1 [Rattus norvegicus]","gi|672079600|ref|XM_006252872.2|",1663,0,"PREDICTED: Rattus norvegicus cytokine receptor-like factor 1 (Crlf1), transcript variant X1, mRNA","Q9JM58",603,0,"Cytokine receptor-like factor 1",".",".",".",".","pfam09067","EpoR_lig-bind","Erythropoietin receptor, ligand binding. Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.","GO:0001657|ureteric bud development;GO:0008150|biological_process;GO:0008284|positive regulation of cell proliferation;GO:0019221|cytokine-mediated signaling pathway;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0043524|negative regulation of neuron apoptotic process;GO:2000672|negative regulation of motor neuron apoptotic process;","GO:0005575|cellular_component;GO:0009897|external side of plasma membrane;GO:0043235|receptor complex;GO:0097058|CRLF-CLCF1 complex;","GO:0003674|molecular_function;GO:0004896|cytokine receptor activity;GO:0005125|cytokine activity;GO:0005127|ciliary neurotrophic factor receptor binding;GO:0019955|cytokine binding;","K24481","CRLF1; cytokine receptor-like factor 1"]
["ENSRNOG00000063752",337,21.67935767,1067,68.88750425,0.314706679,-1.667920299,{"v":3.75952E-89,"d":"3.76E-89"},{"v":2.03139e-88,"d":"2.03E-88"},"down","yes","Crocc2","protein_coding","chr9:93708684-93769402:+","gi|672066203|ref|XP_008765608.1|",6916,0,"PREDICTED: LOW QUALITY PROTEIN: putative ciliary rootlet coiled-coil protein-like 3 protein isoform X2 [Rattus norvegicus]","gi|672066202|ref|XM_008767386.1|",6494,0,"PREDICTED: Rattus norvegicus putative ciliary rootlet coiled-coil protein-like 3 protein-like (LOC102551034), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam15035","Rootletin","Ciliary rootlet component, centrosome cohesion.",".",".",".",".","."]
["ENSRNOG00000040287",515,33.13017567,1363,87.99781471,0.376488618,-1.409321844,{"v":6.16088e-89,"d":"6.16E-89"},{"v":3.3195e-88,"d":"3.32E-88"},"down","yes","Cyp1b1","protein_coding","chr6:15342344-15350917:+","gi|6978737|ref|NP_037072.1|",2580,0,"cytochrome P450 1B1 [Rattus norvegicus]","gi|1039376|gb|U09540.1|RNU09540",4896,0,"Rattus norvegicus Sprague-Dawley cytochrome P450 (CYP1B1) mRNA, complete cds","Q64678",998,0,"Cytochrome P450 1B1","VNG0422G",76.3,{"v":3e-13,"d":"3.00E-13"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0001525|angiogenesis;GO:0002930|trabecular meshwork development;GO:0006304|DNA modification;GO:0006725|cellular aromatic compound metabolic process;GO:0006805|xenobiotic metabolic process;GO:0006809|nitric oxide biosynthetic process;GO:0007155|cell adhesion;GO:0007584|response to nutrient;GO:0008202|steroid metabolic process;GO:0008210|estrogen metabolic process;GO:0008285|negative regulation of cell proliferation;GO:0008584|male gonad development;GO:0008631|intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0009404|toxin metabolic process;GO:0009636|response to toxic substance;GO:0010033|response to organic substance;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0014070|response to organic cyclic compound;GO:0014911|positive regulation of smooth muscle cell migration;GO:0019369|arachidonic acid metabolic process;GO:0030199|collagen fibril organization;GO:0030325|adrenal gland development;GO:0030336|negative regulation of cell migration;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0032354|response to follicle-stimulating hormone;GO:0032355|response to estradiol;GO:0033629|negative regulation of cell adhesion mediated by integrin;GO:0042537|benzene-containing compound metabolic process;GO:0042572|retinol metabolic process;GO:0042574|retinal metabolic process;GO:0043065|positive regulation of apoptotic process;GO:0043542|endothelial cell migration;GO:0044849|estrous cycle;GO:0045727|positive regulation of translation;GO:0045766|positive regulation of angiogenesis;GO:0046427|positive regulation of JAK-STAT cascade;GO:0046466|membrane lipid catabolic process;GO:0046685|response to arsenic-containing substance;GO:0048514|blood vessel morphogenesis;GO:0048545|response to steroid hormone;GO:0061298|retina vasculature development in camera-type eye;GO:0061304|retinal blood vessel morphogenesis;GO:0061548|ganglion development;GO:0070301|cellular response to hydrogen peroxide;GO:0071320|cellular response to cAMP;GO:0071356|cellular response to tumor necrosis factor;GO:0071373|cellular response to luteinizing hormone stimulus;GO:0071387|cellular response to cortisol stimulus;GO:0071393|cellular response to progesterone stimulus;GO:0071407|cellular response to organic cyclic compound;GO:0071548|response to dexamethasone;GO:0071603|endothelial cell-cell adhesion;GO:0071680|response to indole-3-methanol;GO:2000377|regulation of reactive oxygen species metabolic process;GO:2000379|positive regulation of reactive oxygen species metabolic process;GO:2000573|positive regulation of DNA biosynthetic process;","GO:0005634|nucleus;GO:0005739|mitochondrion;GO:0005789|endoplasmic reticulum membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0004497|monooxygenase activity;GO:0005506|iron ion binding;GO:0016491|oxidoreductase activity;GO:0016705|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0016712|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0020037|heme binding;GO:0070330|aromatase activity;GO:0101020|estrogen 16-alpha-hydroxylase activity;","K07410","CYP1B1; cytochrome P450 family 1 subfamily B1 [EC:1.14.14.1]"]
["ENSRNOG00000001300",576,37.05433239,1460,94.2603151,0.393106392,-1.347008272,{"v":6.27998e-89,"d":"6.28E-89"},{"v":3.38048e-88,"d":"3.38E-88"},"down","yes","P2rx4","protein_coding","chr12:33844396-33862253:-","gi|1709521|sp|P51577.1|P2RX4_RAT",1760,0,"RecName: Full=P2X purinoceptor 4; Short=P2X4; AltName: Full=ATP receptor; AltName: Full=Purinergic receptor","gi|1325958|emb|X93565.1|",1049,0,"R.norvegicus mRNA for P2X4 protein","P51577",682,0,"P2X purinoceptor 4",".",".",".",".","pfam00864","P2X_receptor","ATP P2X receptor.","GO:0002028|regulation of sodium ion transport;GO:0002931|response to ischemia;GO:0006809|nitric oxide biosynthetic process;GO:0006816|calcium ion transport;GO:0007165|signal transduction;GO:0008217|regulation of blood pressure;GO:0010524|positive regulation of calcium ion transport into cytosol;GO:0010614|negative regulation of cardiac muscle hypertrophy;GO:0019228|neuronal action potential;GO:0019233|sensory perception of pain;GO:0019722|calcium-mediated signaling;GO:0033198|response to ATP;GO:0034220|ion transmembrane transport;GO:0034405|response to fluid shear stress;GO:0035590|purinergic nucleotide receptor signaling pathway;GO:0042311|vasodilation;GO:0043536|positive regulation of blood vessel endothelial cell migration;GO:0048266|behavioral response to pain;GO:0048678|response to axon injury;GO:0050850|positive regulation of calcium-mediated signaling;GO:0050920|regulation of chemotaxis;GO:0050975|sensory perception of touch;GO:0051897|positive regulation of protein kinase B signaling;GO:0051899|membrane depolarization;GO:0055117|regulation of cardiac muscle contraction;GO:0055119|relaxation of cardiac muscle;GO:0060079|excitatory postsynaptic potential;GO:0070588|calcium ion transmembrane transport;GO:0071294|cellular response to zinc ion;GO:0071318|cellular response to ATP;GO:0097190|apoptotic signaling pathway;GO:0098662|inorganic cation transmembrane transport;GO:1904141|positive regulation of microglial cell migration;GO:2001028|positive regulation of endothelial cell chemotaxis;","GO:0005639|integral component of nuclear inner membrane;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0030054|cell junction;GO:0030424|axon;GO:0030425|dendrite;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0043197|dendritic spine;GO:0044297|cell body;GO:0045177|apical part of cell;GO:0045202|synapse;GO:0048471|perinuclear region of cytoplasm;","GO:0001614|purinergic nucleotide receptor activity;GO:0004931|extracellularly ATP-gated cation channel activity;GO:0005102|signaling receptor binding;GO:0005507|copper ion binding;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0008270|zinc ion binding;GO:0042802|identical protein binding;GO:0045296|cadherin binding;GO:0099604|ligand-gated calcium channel activity;","K05218","P2RX4; P2X purinoceptor 4"]
["ENSRNOG00000000699",39,2.508887089,452,29.18196056,0.085973904,-3.539957363,{"v":6.43412e-89,"d":"6.43E-89"},{"v":3.46019E-88,"d":"3.46E-88"},"down","yes","Selplg","protein_coding","chr12:42796580-42812585:+","gi|61557366|ref|NP_001013248.1|",2026,0,"P-selectin glycoprotein ligand 1 precursor [Rattus norvegicus]","gi|157100914|emb|AM778467.1|",1188,0,"Rattus norvegicus mRNA for P-selectin glycoprotein ligand 1 propeptide precursor (Selplg gene)","Q62170",551,{"v":3e-177,"d":"3.00E-177"},"P-selectin glycoprotein ligand 1",".",".",".",".","pfam05109","Herpes_BLLF1","Herpes virus major outer envelope glycoprotein (BLLF1). This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralizing antibodies in vivo.","GO:0030097|hemopoiesis;GO:0050900|leukocyte migration;GO:0050901|leukocyte tethering or rolling;GO:0050902|leukocyte adhesive activation;GO:0071354|cellular response to interleukin-6;","GO:0001931|uropod;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0044853|plasma membrane raft;",".","K06544","SELPLG, CD162; selectin P ligand"]
["ENSRNOG00000008312",11,0.70763482,372,24.01701179,0.029463899,-5.084907812,{"v":2.09393e-88,"d":"2.09E-88"},{"v":1.12292E-87,"d":"1.12E-87"},"down","yes","Stra6","protein_coding","chr8:58549736-58568860:+","gi|71361637|ref|NP_001025095.1|",2795,0,"stimulated by retinoic acid gene 6 protein homolog [Rattus norvegicus]","gi|71361636|ref|NM_001029924.1|",2622,0,"Rattus norvegicus stimulated by retinoic acid 6 (Stra6), mRNA","Q4QR83",1081,0,"Receptor for retinol uptake STRA6",".",".",".",".","pfam14752","RBP_receptor","Retinol binding protein receptor. Proteins in this family function as retinol binding protein receptors.","GO:0001568|blood vessel development;GO:0001822|kidney development;GO:0003184|pulmonary valve morphogenesis;GO:0003281|ventricular septum development;GO:0007507|heart development;GO:0007612|learning;GO:0007631|feeding behavior;GO:0030324|lung development;GO:0030325|adrenal gland development;GO:0030540|female genitalia development;GO:0032526|response to retinoic acid;GO:0034633|retinol transport;GO:0042297|vocal learning;GO:0043010|camera-type eye development;GO:0043583|ear development;GO:0043585|nose morphogenesis;GO:0046427|positive regulation of JAK-STAT cascade;GO:0048286|lung alveolus development;GO:0048520|positive regulation of behavior;GO:0048546|digestive tract morphogenesis;GO:0048566|embryonic digestive tract development;GO:0048589|developmental growth;GO:0048745|smooth muscle tissue development;GO:0048844|artery morphogenesis;GO:0050890|cognition;GO:0050905|neuromuscular process;GO:0060322|head development;GO:0060323|head morphogenesis;GO:0060325|face morphogenesis;GO:0060426|lung vasculature development;GO:0060539|diaphragm development;GO:0060900|embryonic camera-type eye formation;GO:0061029|eyelid development in camera-type eye;GO:0061038|uterus morphogenesis;GO:0061143|alveolar primary septum development;GO:0061156|pulmonary artery morphogenesis;GO:0061205|paramesonephric duct development;GO:0071939|vitamin A import;GO:0097070|ductus arteriosus closure;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0032991|protein-containing complex;","GO:0016918|retinal binding;GO:0019841|retinol binding;GO:0034632|retinol transmembrane transporter activity;GO:0038023|signaling receptor activity;","K23088","STRA6; vitamin A receptor/transporter (stra6) family protein"]
["ENSRNOG00000006646",433,27.85507973,1225,79.08827808,0.35220238,-1.505523439,{"v":3.06044e-88,"d":"3.06E-88"},{"v":1.63969e-87,"d":"1.64E-87"},"down","yes","Vopp1","protein_coding","chr4:87363477-87450375:+","gi|568941508|ref|XP_006506015.1|",532,{"v":4e-59,"d":"4.00E-59"},"PREDICTED: vesicular, overexpressed in cancer, prosurvival protein 1 isoform X2 [Mus musculus]","gi|672049847|ref|XM_006236578.2|",2619,0,"PREDICTED: Rattus norvegicus vesicular, overexpressed in cancer, prosurvival protein 1 (Vopp1), transcript variant X1, mRNA","B5DEK8",209,{"v":2e-60,"d":"2.00E-60"},"Vesicular, overexpressed in cancer, prosurvival protein 1",".",".",".",".","pfam10204","DuoxA","Dual oxidase maturation factor. DuoxA (Dual oxidase maturation factor) is the essential protein necessary for the final release of DUOX2 (an NADPH:O2 oxidoreductase flavoprotein) from the endoplasmic reticulum. Dual oxidases (DUOX1 and DUOX2) constitute the catalytic core of the hydrogen peroxide generator, which generates H2O2 at the apical membrane of thyroid follicular cells, essential for iodination of thyroglobulin by thyroid peroxidases. DuoxA carries five membrane-integral regions including a reverse signal-anchor with external N-terminus (type III) and two N-glycosylation sites. It is conserved from nematodes to humans.",".","GO:0005768|endosome;GO:0030659|cytoplasmic vesicle membrane;GO:0031301|integral component of organelle membrane;",".",".","."]
["ENSRNOG00000001962",4,0.257321753,371,23.95244993,0.010743024,-6.540455996,{"v":4.35889e-88,"d":"4.36E-88"},{"v":2.33099e-87,"d":"2.33E-87"},"down","yes","Fam3b","protein_coding","chr11:36831532-36869713:-","gi|564376354|ref|XP_006248219.1|",1261,{"v":6e-173,"d":"6.00E-173"},"PREDICTED: protein FAM3B isoform X1 [Rattus norvegicus]","gi|672070566|ref|XM_006248157.2|",954,0,"PREDICTED: Rattus norvegicus family with sequence similarity 3, member B (Fam3b), transcript variant X1, mRNA","Q9D309",459,{"v":3E-162,"d":"3.00E-162"},"Protein FAM3B",".",".",".",".","pfam06032","DUF917","Protein of unknown function (DUF917). This family consists of hypothetical bacterial and archaeal proteins of unknown function.","GO:0030073|insulin secretion;GO:0042593|glucose homeostasis;","GO:0005615|extracellular space;",".",".","."]
["ENSRNOG00000050071",832,53.52292457,1843,118.9875073,0.449819698,-1.152581257,{"v":6.08843e-88,"d":"6.09E-88"},{"v":3.25285e-87,"d":"3.25E-87"},"down","yes","Cdc45","protein_coding","chr11:82211475-82214992:-","gi|694981804|ref|XP_009436065.1|",752,{"v":4e-87,"d":"4.00E-87"},"PREDICTED: LOW QUALITY PROTEIN: claudin-5 [Pan troglodytes]","gi|298905835|emb|FQ213964.1|",1439,0,"Rattus norvegicus TL0AAA44YJ07 mRNA sequence","Q9JKD6",288,{"v":1E-87,"d":"1.00E-87"},"Claudin-5",".",".",".",".","pfam00822","PMP22_Claudin","PMP-22/EMP/MP20/Claudin family.","GO:0000727|double-strand break repair via break-induced replication;GO:0006270|DNA replication initiation;GO:0051301|cell division;GO:1902977|mitotic DNA replication preinitiation complex assembly;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005813|centrosome;GO:0031261|DNA replication preinitiation complex;GO:0036064|ciliary basal body;","GO:0003682|chromatin binding;GO:0003688|DNA replication origin binding;GO:0003697|single-stranded DNA binding;","K06628","CDC45; cell division control protein 45"]
["ENSRNOG00000000878",8,0.514643505,365,23.56507877,0.021839244,-5.516933273,{"v":6.41248e-88,"d":"6.41E-88"},{"v":3.42277E-87,"d":"3.42E-87"},"down","yes","Slc44a4","protein_coding","chr20:3903099-3919215:-","gi|47087113|ref|NP_997706.1|",3040,0,"choline transporter-like protein 4 [Rattus norvegicus]","gi|47087112|ref|NM_212541.1|",2254,0,"Rattus norvegicus solute carrier family 44, member 4 (Slc44a4), mRNA","Q6MG71",1175,0,"Choline transporter-like protein 4",".",".",".",".","pfam04515","Choline_transpo","Plasma-membrane choline transporter. This family represents a high-affinity plasma-membrane choline transporter in C.elegans which is thought to be rate-limiting for ACh synthesis in cholinergic nerve terminals.","GO:0008292|acetylcholine biosynthetic process;GO:0015871|choline transport;GO:0030307|positive regulation of cell growth;GO:0030974|thiamine pyrophosphate transmembrane transport;GO:0032475|otolith formation;GO:0035675|neuromast hair cell development;GO:0055085|transmembrane transport;GO:0061526|acetylcholine secretion;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;","GO:0015220|choline transmembrane transporter activity;GO:0022857|transmembrane transporter activity;GO:0090422|thiamine pyrophosphate transmembrane transporter activity;","K15377","SLC44A2_4_5; solute carrier family 44 (choline transporter-like protein), member 2/4/5"]
["ENSRNOG00000017699",741,47.66885469,1703,109.948847,0.433554839,-1.205713607,{"v":2.56683e-87,"d":"2.57E-87"},{"v":1.35741E-86,"d":"1.36E-86"},"down","yes","Mill1","protein_coding","chr1:78372802-78398930:+","gi|58865432|ref|NP_001011931.1|",2072,0,"MHC I like leukocyte 1 precursor [Rattus norvegicus]","gi|77404357|ref|NM_001011931.2|",2686,0,"Rattus norvegicus MHC I like leukocyte 1 (Mill1), mRNA","Q9GL42",149,{"v":1e-37,"d":"1.00E-37"},"Hereditary hemochromatosis protein homolog",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.","GO:0001913|T cell mediated cytotoxicity;GO:0002418|immune response to tumor cell;GO:0006955|immune response;GO:0006974|cellular response to DNA damage stimulus;GO:0009408|response to heat;GO:0032815|negative regulation of natural killer cell activation;GO:0042267|natural killer cell mediated cytotoxicity;GO:0042742|defense response to bacterium;GO:0045953|negative regulation of natural killer cell mediated cytotoxicity;GO:0046629|gamma-delta T cell activation;GO:0051607|defense response to virus;","GO:0005615|extracellular space;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0031362|anchored component of external side of plasma membrane;","GO:0046703|natural killer cell lectin-like receptor binding;",".","."]
["ENSRNOG00000065935",36,2.315895775,437,28.21353267,0.082084573,-3.606745087,{"v":3.08999e-87,"d":"3.09E-87"},{"v":1.63255e-86,"d":"1.63E-86"},"down","yes","Kng2l1","protein_coding","chr11:77909612-78002971:+","gi|149019923|gb|EDL78071.1|",2265,0,"rCG36716, isoform CRA_d [Rattus norvegicus]","gi|80861400|ref|NM_012696.2|",1441,0,"Rattus norvegicus kininogen 1 (Kng1), mRNA","P08934",873,0,"Kininogen-1",".",".",".",".","pfam00031","Cystatin","Cystatin domain. Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 are related to this family but have not been included.",".",".",".",".","."]
["ENSRNOG00000012347",192,12.35144413,790,51.00386913,0.242166807,-2.045926962,{"v":3.65454e-87,"d":"3.65E-87"},{"v":1.92904e-86,"d":"1.93E-86"},"down","yes","Gata2","protein_coding","chr4:120658986-120667761:+","gi|15559217|ref|NP_254277.1|",2056,0,"endothelial transcription factor GATA-2 [Rattus norvegicus]","gi|15559216|ref|NM_033442.1|",3411,0,"Rattus norvegicus GATA binding protein 2 (Gata2), mRNA","Q924Y4",796,0,"Endothelial transcription factor GATA-2","SPCC1393.08",108,{"v":2e-23,"d":"2.00E-23"},"COG5641","pfam00320","GATA","GATA zinc finger. This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contains a single copy of the domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001655|urogenital system development;GO:0001709|cell fate determination;GO:0001764|neuron migration;GO:0001892|embryonic placenta development;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006909|phagocytosis;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010725|regulation of primitive erythrocyte differentiation;GO:0021514|ventral spinal cord interneuron differentiation;GO:0021533|cell differentiation in hindbrain;GO:0021902|commitment of neuronal cell to specific neuron type in forebrain;GO:0021954|central nervous system neuron development;GO:0021983|pituitary gland development;GO:0030154|cell differentiation;GO:0030182|neuron differentiation;GO:0033993|response to lipid;GO:0035019|somatic stem cell population maintenance;GO:0035065|regulation of histone acetylation;GO:0035854|eosinophil fate commitment;GO:0042472|inner ear morphogenesis;GO:0043306|positive regulation of mast cell degranulation;GO:0043536|positive regulation of blood vessel endothelial cell migration;GO:0045165|cell fate commitment;GO:0045599|negative regulation of fat cell differentiation;GO:0045638|negative regulation of myeloid cell differentiation;GO:0045648|positive regulation of erythrocyte differentiation;GO:0045650|negative regulation of macrophage differentiation;GO:0045654|positive regulation of megakaryocyte differentiation;GO:0045666|positive regulation of neuron differentiation;GO:0045746|negative regulation of Notch signaling pathway;GO:0045766|positive regulation of angiogenesis;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048469|cell maturation;GO:0048663|neuron fate commitment;GO:0048873|homeostasis of number of cells within a tissue;GO:0050766|positive regulation of phagocytosis;GO:0060100|positive regulation of phagocytosis, engulfment;GO:0060216|definitive hemopoiesis;GO:0060872|semicircular canal development;GO:0061042|vascular wound healing;GO:0070345|negative regulation of fat cell proliferation;GO:0090050|positive regulation of cell migration involved in sprouting angiogenesis;GO:0090102|cochlea development;GO:0097154|GABAergic neuron differentiation;GO:1902895|positive regulation of pri-miRNA transcription by RNA polymerase II;GO:1903589|positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:2000178|negative regulation of neural precursor cell proliferation;GO:2000352|negative regulation of endothelial cell apoptotic process;GO:2000977|regulation of forebrain neuron differentiation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005737|cytoplasm;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003700|DNA-binding transcription factor activity;GO:0005515|protein binding;GO:0008270|zinc ion binding;GO:0043565|sequence-specific DNA binding;GO:0070742|C2H2 zinc finger domain binding;GO:1990837|sequence-specific double-stranded DNA binding;","K17894","GATA2; GATA-binding protein 2"]
["ENSRNOG00000019937",25,1.608260955,405,26.14755316,0.06150713,-4.023102527,{"v":4.44376e-87,"d":"4.44E-87"},{"v":2.34346e-86,"d":"2.34E-86"},"down","yes","Kcnk1","protein_coding","chr19:53959657-53997724:+","gi|11067417|ref|NP_067720.1|",1376,0,"potassium channel subfamily K member 1 [Rattus norvegicus]","gi|38511568|gb|BC061807.1|",2202,0,"Rattus norvegicus potassium channel, subfamily K, member 1, mRNA (cDNA clone MGC:72470 IMAGE:5598415), complete cds","Q9Z2T2",534,0,"Potassium channel subfamily K member 1",".",".",".",".","pfam07885","Ion_trans_2","Ion channel. This family includes the two membrane helix type ion channels found in bacteria.","GO:0030322|stabilization of membrane potential;GO:0035094|response to nicotine;GO:0035725|sodium ion transmembrane transport;GO:0060075|regulation of resting membrane potential;GO:0071805|potassium ion transmembrane transport;","GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0030425|dendrite;GO:0031526|brush border membrane;GO:0034705|potassium channel complex;GO:0043204|perikaryon;GO:0043231|intracellular membrane-bounded organelle;GO:0055037|recycling endosome;GO:0097060|synaptic membrane;GO:1902937|inward rectifier potassium channel complex;","GO:0005242|inward rectifier potassium channel activity;GO:0005267|potassium channel activity;GO:0005272|sodium channel activity;GO:0022841|potassium ion leak channel activity;GO:0042802|identical protein binding;","K04912","KCNK1, K2P1.1; potassium channel subfamily K member 1"]
["ENSRNOG00000016413",130,8.362956964,662,42.73995109,0.195670719,-2.353500213,{"v":6.93012e-87,"d":"6.93E-87"},{"v":3.64793e-86,"d":"3.65E-86"},"down","yes","Pstpip1","protein_coding","chr8:56499590-56538580:+","gi|166157470|ref|NP_001100294.2|",2073,0,"proline-serine-threonine phosphatase-interacting protein 1 [Rattus norvegicus]","gi|166157469|ref|NM_001106824.2|",1539,0,"Rattus norvegicus proline-serine-threonine phosphatase-interacting protein 1 (Pstpip1), mRNA","P97814",768,0,"Proline-serine-threonine phosphatase-interacting protein 1",".",".",".",".","pfam00611","FCH","Fes/CIP4, and EFC/F-BAR homology domain. Alignment extended from. Highly alpha-helical. The cytosolic endocytic adaptor proteins in fungi carry this domain at the N-terminus; several of these have been referred to as muniscin proteins. These N-terminal BAR, N-BAR, and EFC/F-BAR domains are found in proteins that regulate membrane trafficking events by inducing membrane tubulation. The domain dimerises into a curved structure that binds to liposomes and either senses or induces the curvature of the membrane bilayer to cause biophysical changes to the shape of the bilayer; it also thereby recruits other trafficking factors, such as the GTPase dynamin. Most EFC/F-BAR domain-family members localize to actin-rich structures.","GO:0008150|biological_process;GO:0030041|actin filament polymerization;","GO:0001725|stress fiber;GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005826|actomyosin contractile ring;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0032154|cleavage furrow;","GO:0003674|molecular_function;GO:0003779|actin binding;GO:0019903|protein phosphatase binding;GO:0042802|identical protein binding;GO:0051015|actin filament binding;","K12804","PSTPIP1; proline-serine-threonine phosphatase interacting protein 1"]
["ENSRNOG00000015845",402,25.86083615,1165,75.2145665,0.343827497,-1.540243168,{"v":8.16331e-87,"d":"8.16E-87"},{"v":4.29311e-86,"d":"4.29E-86"},"down","yes","Niban2","protein_coding","chr3:16174659-16224293:+","gi|158081781|ref|NP_001103355.1|",3739,0,"niban-like protein 1 [Rattus norvegicus]","gi|158081780|ref|NM_001109885.1|",3435,0,"Rattus norvegicus family with sequence similarity 129, member B (Fam129b), mRNA","B4F7E8",1444,0,"Niban-like protein 1",".",".",".",".","pfam15258","FAM222A","Protein family of FAM222A. This protein family, FAM222A are a domain of unknown function. This family of proteins is found in eukaryotes and are typically between 411 and 562 amino acids in length. In humans, the gene encoding this protein domain lies in the position, chromosome 12 open reading frame 34.","GO:0008285|negative regulation of cell proliferation;GO:0032274|gonadotropin secretion;GO:0043066|negative regulation of apoptotic process;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:2000279|negative regulation of DNA biosynthetic process;GO:2000679|positive regulation of transcription regulatory region DNA binding;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005912|adherens junction;","GO:0003713|transcription coactivator activity;",".","."]
["ENSRNOG00000023536",20,1.286608764,389,25.11456341,0.051229589,-4.286878869,{"v":1.11796E-86,"d":"1.12E-86"},{"v":5.87397e-86,"d":"5.87E-86"},"down","yes","Adgrd1","protein_coding","chr12:27488908-27603696:-","gi|392352491|ref|XP_001070157.3|",4739,0,"PREDICTED: probable G-protein coupled receptor 133 isoform X2 [Rattus norvegicus]","gi|672072883|ref|XM_001070157.6|",5109,0,"PREDICTED: Rattus norvegicus G protein-coupled receptor 133 (Gpr133), transcript variant X2, mRNA","Q80T32",1692,0,"Adhesion G-protein coupled receptor D1",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0007166|cell surface receptor signaling pathway;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;","GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;","GO:0004930|G protein-coupled receptor activity;","K08465","ADGRD1, GPR133; adhesion G-protein coupled receptor D1"]
["ENSRNOG00000019308",519,33.38749742,1352,87.28763425,0.38249974,-1.386469327,{"v":4.02353e-86,"d":"4.02E-86"},{"v":2.10051E-85,"d":"2.10E-85"},"down","yes","Arrb2","protein_coding","chr10:55146818-55154850:+","gi|6978539|ref|NP_037043.1|",1868,0,"beta-arrestin-2 [Rattus norvegicus]","gi|56270584|gb|BC087578.1|",1531,0,"Rattus norvegicus arrestin, beta 2, mRNA (cDNA clone MGC:105502 IMAGE:7311618), complete cds","P29067",724,0,"Beta-arrestin-2",".",".",".",".","pfam00339","Arrestin_N","Arrestin (or S-antigen), N-terminal domain. Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.","GO:0001932|regulation of protein phosphorylation;GO:0001933|negative regulation of protein phosphorylation;GO:0001934|positive regulation of protein phosphorylation;GO:0002031|G protein-coupled receptor internalization;GO:0002032|desensitization of G protein-coupled receptor signaling pathway by arrestin;GO:0002092|positive regulation of receptor internalization;GO:0006366|transcription by RNA polymerase II;GO:0006897|endocytosis;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007420|brain development;GO:0007628|adult walking behavior;GO:0008277|regulation of G protein-coupled receptor signaling pathway;GO:0010628|positive regulation of gene expression;GO:0015031|protein transport;GO:0016567|protein ubiquitination;GO:0031397|negative regulation of protein ubiquitination;GO:0031623|receptor internalization;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0032226|positive regulation of synaptic transmission, dopaminergic;GO:0032691|negative regulation of interleukin-1 beta production;GO:0032695|negative regulation of interleukin-12 production;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032967|positive regulation of collagen biosynthetic process;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0034122|negative regulation of toll-like receptor signaling pathway;GO:0034260|negative regulation of GTPase activity;GO:0034392|negative regulation of smooth muscle cell apoptotic process;GO:0042699|follicle-stimulating hormone signaling pathway;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043524|negative regulation of neuron apoptotic process;GO:0045953|negative regulation of natural killer cell mediated cytotoxicity;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050965|detection of temperature stimulus involved in sensory perception of pain;GO:0051897|positive regulation of protein kinase B signaling;GO:0051928|positive regulation of calcium ion transport;GO:0060326|cell chemotaxis;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0090201|negative regulation of release of cytochrome c from mitochondria;GO:1904037|positive regulation of epithelial cell apoptotic process;GO:2000573|positive regulation of DNA biosynthetic process;GO:2000727|positive regulation of cardiac muscle cell differentiation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005905|clathrin-coated pit;GO:0014069|postsynaptic density;GO:0016323|basolateral plasma membrane;GO:0030139|endocytic vesicle;GO:0031410|cytoplasmic vesicle;GO:0043197|dendritic spine;GO:0045211|postsynaptic membrane;","GO:0001664|G protein-coupled receptor binding;GO:0005102|signaling receptor binding;GO:0005515|protein binding;GO:0019899|enzyme binding;GO:0019904|protein domain specific binding;GO:0031625|ubiquitin protein ligase binding;GO:0031691|alpha-1A adrenergic receptor binding;GO:0031692|alpha-1B adrenergic receptor binding;GO:0031701|angiotensin receptor binding;GO:0031702|type 1 angiotensin receptor binding;GO:0031748|D1 dopamine receptor binding;GO:0031762|follicle-stimulating hormone receptor binding;GO:0031826|type 2A serotonin receptor binding;GO:0031859|platelet activating factor receptor binding;GO:0042802|identical protein binding;GO:0043422|protein kinase B binding;GO:0044877|protein-containing complex binding;GO:0051019|mitogen-activated protein kinase binding;GO:0071889|14-3-3 protein binding;GO:1990763|arrestin family protein binding;","K04439","ARRB; beta-arrestin"]
["ENSRNOG00000012658",348,22.38699249,1069,69.01662797,0.324370998,-1.624283261,{"v":4.59374e-86,"d":"4.59E-86"},{"v":2.39601E-85,"d":"2.40E-85"},"down","yes","Pdlim3","protein_coding","chr16:46352467-46383657:-","gi|149021402|gb|EDL78865.1|",1895,0,"PDZ and LIM domain 3, isoform CRA_b [Rattus norvegicus]","gi|298896337|emb|FQ215471.1|",1561,0,"Rattus norvegicus TL0ACA48YB23 mRNA sequence","Q66HS7",711,0,"PDZ and LIM domain protein 3",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.","GO:0007015|actin filament organization;GO:0007507|heart development;GO:0008150|biological_process;GO:0030036|actin cytoskeleton organization;GO:0061061|muscle structure development;","GO:0001725|stress fiber;GO:0005829|cytosol;GO:0005912|adherens junction;GO:0015629|actin cytoskeleton;GO:0030018|Z disc;GO:0031941|filamentous actin;","GO:0003779|actin binding;GO:0008092|cytoskeletal protein binding;GO:0008307|structural constituent of muscle;GO:0042805|actinin binding;GO:0046872|metal ion binding;GO:0051371|muscle alpha-actinin binding;","K23353","PDLIM1_2_3_4; PDZ and LIM domain protein 1/2/3/4"]
["ENSRNOG00000070011",51,3.280852347,472,30.47319776,0.10766354,-3.215398327,{"v":8.52956e-86,"d":"8.53E-86"},{"v":4.44479e-85,"d":"4.44E-85"},"down","yes","ENSRNOG00000070011","lncRNA","chr18:55095230-55118825:-","gi|149064411|gb|EDM14614.1|",541,{"v":1E-58,"d":"1.00E-58"},"rCG46786 [Rattus norvegicus]","gi|56044724|gb|AC115691.8|",1730,0,"Mus musculus chromosome 18, clone RP24-286B14, complete sequence",".",".",".",".",".",".",".",".","pfam12234","Rav1p_C","RAVE protein 1 C terminal. This domain family is found in eukaryotes, and is typically between 621 and 644 amino acids in length. This family is the C terminal region of the protein RAVE (regulator of the ATPase of vacuolar and endosomal membranes). Rav1p is involved in regulating the glucose dependent assembly and disassembly of vacuolar ATPase V1 and V0 subunits.",".",".",".",".","."]
["ENSRNOG00000047606",56,3.602504538,485,31.31250193,0.115050038,-3.119666634,{"v":8.69859e-86,"d":"8.70E-86"},{"v":4.52875e-85,"d":"4.53E-85"},"down","yes","Bcl2a1","protein_coding","chr8:89716914-89724998:+","gi|149018936|gb|EDL77577.1|",933,{"v":2E-125,"d":"2.00E-125"},"B-cell leukemia/lymphoma 2 related protein A1 [Rattus norvegicus]","gi|19173783|ref|NM_133416.1|",696,0,"Rattus norvegicus BCL2-related protein A1 (Bcl2a1), mRNA","Q07440",325,{"v":5e-112,"d":"5.00E-112"},"Bcl-2-related protein A1",".",".",".",".","pfam00452","Bcl-2","Apoptosis regulator proteins, Bcl-2 family.","GO:0006915|apoptotic process;GO:0007568|aging;GO:0008630|intrinsic apoptotic signaling pathway in response to DNA damage;GO:0021987|cerebral cortex development;GO:0043066|negative regulation of apoptotic process;GO:0097192|extrinsic apoptotic signaling pathway in absence of ligand;","GO:0005575|cellular_component;GO:0005741|mitochondrial outer membrane;","GO:0042803|protein homodimerization activity;GO:0044877|protein-containing complex binding;GO:0046982|protein heterodimerization activity;GO:0051400|BH domain binding;","K02162","BCL2A1; hematopoietic Bcl-2-related protein A1"]
["ENSRNOG00000018371",708,45.54595023,1642,106.0105736,0.429635919,-1.218813481,{"v":1.12464E-85,"d":"1.12E-85"},{"v":5.83925e-85,"d":"5.84E-85"},"down","yes","Tubb6","protein_coding","chr18:60943375-60954418:+","gi|71043680|ref|NP_001020846.1|",2197,0,"tubulin beta-6 chain [Rattus norvegicus]","gi|71043679|ref|NM_001025675.1|",1719,0,"Rattus norvegicus tubulin, beta 6 class V (Tubb6), mRNA","Q922F4",847,0,"Tubulin beta-6 chain","ECU03g0820i",704,0,"COG5023","pfam03953","Tubulin_C","Tubulin C-terminal domain. This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).","GO:0000226|microtubule cytoskeleton organization;GO:0000278|mitotic cell cycle;","GO:0005737|cytoplasm;GO:0005874|microtubule;","GO:0003924|GTPase activity;GO:0005200|structural constituent of cytoskeleton;GO:0005525|GTP binding;","K07375","TUBB; tubulin beta"]
["ENSRNOG00000060775",152,9.778226604,701,45.25786362,0.216055859,-2.21052374,{"v":2.52817e-85,"d":"2.53E-85"},{"v":1.30908e-84,"d":"1.31E-84"},"down","yes","Lmo7","protein_coding","chr15:78567023-78769783:+","gi|48040390|ref|NP_001001515.1|",7334,0,"LIM domain only protein 7 [Rattus norvegicus]","gi|48040389|ref|NM_001001515.1|",4956,0,"Rattus norvegicus LIM domain 7 (Lmo7), mRNA","Q8WWI1",1222,0,"LIM domain only protein 7",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.","GO:0023051|regulation of signaling;GO:0030155|regulation of cell adhesion;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;GO:0005635|nuclear envelope;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005912|adherens junction;GO:0009986|cell surface;GO:0016324|apical plasma membrane;","GO:0005515|protein binding;GO:0008022|protein C-terminus binding;GO:0042805|actinin binding;GO:0046872|metal ion binding;","K06084","LMO7, FBXO20; F-box protein 20"]
["ENSRNOG00000022975",77,4.95344374,535,34.54059492,0.143409335,-2.80178916,{"v":3.1278e-85,"d":"3.13E-85"},{"v":1.6181E-84,"d":"1.62E-84"},"down","yes","Nfam1","protein_coding","chr7:114139345-114175442:-","gi|564309086|ref|XP_006226237.1|",1205,{"v":4e-155,"d":"4.00E-155"},"PREDICTED: NFAT activation molecule 1 isoform X1 [Rattus norvegicus]","gi|672022166|ref|XM_006226175.2|",2841,0,"PREDICTED: Rattus norvegicus NFAT activating protein with ITAM motif 1 (Nfam1), transcript variant X1, mRNA","Q8R4V1",284,{"v":1e-86,"d":"1.00E-86"},"NFAT activation molecule 1",".",".",".",".","pfam15068","FAM101","FAM101 family. This protein family includes the actin regulators, Refilin A and B, however the exact function of this protein family remains unknown. Refilin is thought to stabilize peri-nuclear actin filament bundles, important in fibroblasts. Refilin is important as changes in localisation and shape in the nucleus plays a role in cellular and developmental processes.","GO:0001819|positive regulation of cytokine production;GO:0007165|signal transduction;GO:0030183|B cell differentiation;GO:0035556|intracellular signal transduction;GO:0045577|regulation of B cell differentiation;GO:0050853|B cell receptor signaling pathway;GO:0050861|positive regulation of B cell receptor signaling pathway;GO:0051091|positive regulation of DNA-binding transcription factor activity;","GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0045121|membrane raft;","GO:0004888|transmembrane signaling receptor activity;",".","."]
["ENSRNOG00000000777",381,24.50989695,1118,72.18015909,0.339565571,-1.558237905,{"v":8.73064e-85,"d":"8.73E-85"},{"v":4.50031e-84,"d":"4.50E-84"},"down","yes","RT1-S3","protein_coding","chr20:2670709-2675411:+","gi|261878529|ref|NP_001008886.2|",1806,0,"RT1 class Ib, locus S3 precursor [Rattus norvegicus]","gi|261878528|ref|NM_001008886.2|",2682,0,"Rattus norvegicus RT1 class Ib, locus S3 (RT1-S3), mRNA","P06339",544,0,"H-2 class I histocompatibility antigen, D-37 alpha chain",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.","GO:0001815|positive regulation of antibody-dependent cellular cytotoxicity;GO:0001916|positive regulation of T cell mediated cytotoxicity;GO:0002250|adaptive immune response;GO:0002476|antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002477|antigen processing and presentation of exogenous peptide antigen via MHC class Ib;GO:0002486|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0002489|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent;GO:0002519|natural killer cell tolerance induction;GO:0002639|positive regulation of immunoglobulin production;GO:0002715|regulation of natural killer cell mediated immunity;GO:0002717|positive regulation of natural killer cell mediated immunity;GO:0002729|positive regulation of natural killer cell cytokine production;GO:0006955|immune response;GO:0019731|antibacterial humoral response;GO:0032736|positive regulation of interleukin-13 production;GO:0032753|positive regulation of interleukin-4 production;GO:0032759|positive regulation of TRAIL production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032819|positive regulation of natural killer cell proliferation;GO:0036037|CD8-positive, alpha-beta T cell activation;GO:0042270|protection from natural killer cell mediated cytotoxicity;GO:0045953|negative regulation of natural killer cell mediated cytotoxicity;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;GO:0048839|inner ear development;GO:0050830|defense response to Gram-positive bacterium;GO:2000566|positive regulation of CD8-positive, alpha-beta T cell proliferation;GO:2001187|positive regulation of CD8-positive, alpha-beta T cell activation;","GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0032398|MHC class Ib protein complex;GO:0042612|MHC class I protein complex;","GO:0005102|signaling receptor binding;GO:0030881|beta-2-microglobulin binding;GO:0042288|MHC class I protein binding;GO:0042605|peptide antigen binding;GO:0042608|T cell receptor binding;GO:0046703|natural killer cell lectin-like receptor binding;","K06751","MHC1; MHC class I antigen"]
["ENSRNOG00000015577",256,16.46859218,898,57.97654997,0.284056091,-1.815752254,{"v":1.40525E-84,"d":"1.41E-84"},{"v":7.21746e-84,"d":"7.22E-84"},"down","yes","Lpar6","protein_coding","chr15:48416544-48422331:+","gi|113951677|ref|NP_001039308.1|",1744,0,"lysophosphatidic acid receptor 6 [Rattus norvegicus]","gi|113951676|ref|NM_001045843.1|",1810,0,"Rattus norvegicus lysophosphatidic acid receptor 6 (Lpar6), mRNA","Q4G072",676,0,"Lysophosphatidic acid receptor 6",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001835|blastocyst hatching;GO:0035025|positive regulation of Rho protein signal transduction;GO:0051482|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;","GO:0004930|G protein-coupled receptor activity;GO:0070915|lysophosphatidic acid receptor activity;","K04273","LPAR6, P2RY5; lysophosphatidic acid receptor 6"]
["ENSRNOG00000031163",272,17.49787919,924,59.65515832,0.293317119,-1.76946682,{"v":5.36155e-84,"d":"5.36E-84"},{"v":2.73895e-83,"d":"2.74E-83"},"down","yes","Nfkbiz","protein_coding","chr11:44782676-44810723:+","gi|472824693|dbj|BAN09039.1|",3363,0,"molecule possessing ankyrin-repeats induced by lipopolysaccharide [Rattus norvegicus]","gi|589968227|ref|XM_006996546.1|",2170,0,"PREDICTED: Peromyscus maniculatus bairdii nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta (Nfkbiz), transcript variant X1, mRNA","Q9EST8",1205,0,"NF-kappa-B inhibitor zeta","PAE1861",53.1,2e-06,"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0006954|inflammatory response;GO:0010468|regulation of gene expression;GO:0050729|positive regulation of inflammatory response;GO:0050852|T cell receptor signaling pathway;GO:2000321|positive regulation of T-helper 17 cell differentiation;","GO:0005634|nucleus;GO:0016607|nuclear speck;GO:0036464|cytoplasmic ribonucleoprotein granule;",".","K14242","NFKBIZ; NF-kappa-B inhibitor zeta"]
["ENSRNOG00000011250",18,1.157947887,372,24.01701179,0.048213654,-4.374414429,{"v":8.53517e-84,"d":"8.54E-84"},{"v":4.35241e-83,"d":"4.35E-83"},"down","yes","Inmt","protein_coding","chr4:84318197-84322493:-","gi|157816899|ref|NP_001102492.1|",1260,{"v":9e-172,"d":"9.00E-172"},"indolethylamine N-methyltransferase [Rattus norvegicus]","gi|157816898|ref|NM_001109022.1|",1062,0,"Rattus norvegicus indolethylamine N-methyltransferase (Inmt), mRNA","P40936",461,{"v":8e-162,"d":"8.00E-162"},"Indolethylamine N-methyltransferase",".",".",".",".","pfam01234","NNMT_PNMT_TEMT","NNMT/PNMT/TEMT family.","GO:0009308|amine metabolic process;GO:0032259|methylation;","GO:0005829|cytosol;","GO:0004790|thioether S-methyltransferase activity;GO:0008170|N-methyltransferase activity;GO:0030748|amine N-methyltransferase activity;","K00562","INMT, TEMT; methyltransferase [EC:2.1.1.49 2.1.1.96]"]
["ENSRNOG00000004972",474,30.4926277,1265,81.67075246,0.373360435,-1.42135904,{"v":1.00926e-83,"d":"1.01E-83"},{"v":5.13741e-83,"d":"5.14E-83"},"down","yes","Upp1","protein_coding","chr14:83809960-83829462:+","gi|564384890|ref|XP_006251549.1|",1598,0,"PREDICTED: uridine phosphorylase 1 isoform X2 [Rattus norvegicus]","gi|672076649|ref|XM_006251487.2|",1269,0,"PREDICTED: Rattus norvegicus uridine phosphorylase 1 (Upp1), transcript variant X5, mRNA","P52624",598,0,"Uridine phosphorylase 1","ML2177",102,{"v":3E-23,"d":"3.00E-23"},"COG2820","pfam01048","PNP_UDP_1","Phosphorylase superfamily. Members of this family include: purine nucleoside phosphorylase (PNP) Uridine phosphorylase (UdRPase) 5'-methylthioadenosine phosphorylase (MTA phosphorylase)","GO:0006218|uridine catabolic process;GO:0006220|pyrimidine nucleotide metabolic process;GO:0006248|CMP catabolic process;GO:0006249|dCMP catabolic process;GO:0042149|cellular response to glucose starvation;GO:0044206|UMP salvage;GO:0046050|UMP catabolic process;GO:0046074|dTMP catabolic process;GO:0046079|dUMP catabolic process;GO:0046108|uridine metabolic process;","GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0004850|uridine phosphorylase activity;GO:0009032|thymidine phosphorylase activity;GO:0042802|identical protein binding;GO:0047847|deoxyuridine phosphorylase activity;","K00757","udp, UPP; uridine phosphorylase [EC:2.4.2.3]"]
["ENSRNOG00000056786",1026,66.00302958,2091,134.9988485,0.4889155,-1.03234295,{"v":1.50629e-83,"d":"1.51E-83"},{"v":7.66065e-83,"d":"7.66E-83"},"down","yes","Piezo1","protein_coding","chr19:50544582-50606501:-","gi|672085276|ref|XP_008770848.1|",11070,0,"PREDICTED: piezo-type mechanosensitive ion channel component 1 isoform X1 [Rattus norvegicus]","gi|672085275|ref|XM_008772626.1|",8209,0,"PREDICTED: Rattus norvegicus piezo-type mechanosensitive ion channel component 1 (Piezo1), transcript variant X1, mRNA","Q0KL00",4247,0,"Piezo-type mechanosensitive ion channel component 1",".",".",".",".","pfam12166","DUF3595","Protein of unknown function (DUF3595). This family of proteins is functionally uncharacterized.This family of proteins is found in eukaryotes. Proteins in this family are typically between 578 and 2525 amino acids in length.","GO:0006812|cation transport;GO:0010831|positive regulation of myotube differentiation;GO:0033625|positive regulation of integrin activation;GO:0033634|positive regulation of cell-cell adhesion mediated by integrin;GO:0034220|ion transmembrane transport;GO:0042391|regulation of membrane potential;GO:0050982|detection of mechanical stimulus;GO:0071260|cellular response to mechanical stimulus;GO:0098655|cation transmembrane transport;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0031258|lamellipodium membrane;GO:0033116|endoplasmic reticulum-Golgi intermediate compartment membrane;","GO:0005261|cation channel activity;GO:0008381|mechanosensitive ion channel activity;GO:0042802|identical protein binding;GO:0140135|mechanosensitive cation channel activity;","K22128","PIEZO1_2, FAM38; piezo-type mechanosensitive ion channel component 1/2"]
["ENSRNOG00000014350",338,21.74368811,1036,66.8860866,0.325085368,-1.621109471,{"v":3.0864E-83,"d":"3.09E-83"},{"v":1.55995E-82,"d":"1.56E-82"},"down","yes","Ccn1","protein_coding","chr2:234562408-234565484:-","gi|625223734|ref|XP_003512990.2|",1796,0,"PREDICTED: protein CYR61 isoform X1 [Cricetulus griseus]","gi|31542446|ref|NM_031327.2|",1977,0,"Rattus norvegicus cysteine-rich, angiogenic inducer, 61 (Cyr61), mRNA","Q9ES72",658,0,"Protein CYR61",".",".",".",".","pfam00007","Cys_knot","Cystine-knot domain. The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.","GO:0001649|osteoblast differentiation;GO:0001934|positive regulation of protein phosphorylation;GO:0002041|intussusceptive angiogenesis;GO:0003181|atrioventricular valve morphogenesis;GO:0003278|apoptotic process involved in heart morphogenesis;GO:0003281|ventricular septum development;GO:0006935|chemotaxis;GO:0007155|cell adhesion;GO:0007165|signal transduction;GO:0010518|positive regulation of phospholipase activity;GO:0010811|positive regulation of cell-substrate adhesion;GO:0030198|extracellular matrix organization;GO:0030335|positive regulation of cell migration;GO:0030501|positive regulation of bone mineralization;GO:0030513|positive regulation of BMP signaling pathway;GO:0033690|positive regulation of osteoblast proliferation;GO:0043065|positive regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0043280|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0044319|wound healing, spreading of cells;GO:0045597|positive regulation of cell differentiation;GO:0045669|positive regulation of osteoblast differentiation;GO:0045766|positive regulation of angiogenesis;GO:0045860|positive regulation of protein kinase activity;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0060413|atrial septum morphogenesis;GO:0060548|negative regulation of cell death;GO:0060591|chondroblast differentiation;GO:0060710|chorio-allantoic fusion;GO:0060716|labyrinthine layer blood vessel development;GO:0061036|positive regulation of cartilage development;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:0072593|reactive oxygen species metabolic process;GO:0098609|cell-cell adhesion;GO:2000304|positive regulation of ceramide biosynthetic process;","GO:0005576|extracellular region;GO:0031012|extracellular matrix;","GO:0005178|integrin binding;GO:0005520|insulin-like growth factor binding;GO:0008201|heparin binding;GO:0050840|extracellular matrix binding;","K06829","CYR61, CCN1, IGFBP10; insulin-like growth factor-binding protein 10"]
["ENSRNOG00000066616",8,0.514643505,345,22.27384158,0.023105287,-5.435633171,{"v":4.40033e-83,"d":"4.40E-83"},{"v":2.22207e-82,"d":"2.22E-82"},"down","yes","ENSRNOG00000066616","protein_coding","chr3:149220737-149228279:+","gi|672047882|ref|XP_008760660.1|",2713,0,"PREDICTED: MLV-related proviral Env polyprotein-like isoform X2, partial [Rattus norvegicus]","gi|33342289|gb|AC105631.4|",2155,0,"Rattus norvegicus 1 BAC CH230-132J4 (Children's Hospital Oakland Research Institute) complete sequence","P03355",754,0,"Gag-Pol polyprotein","SPAC167.08",81.3,{"v":3e-14,"d":"3.00E-14"},"COG2801","pfam00429","TLV_coat","ENV polyprotein (coat polyprotein).",".",".",".",".","."]
["ENSRNOG00000006946",213,13.70238333,810,52.29510632,0.262020374,-1.932249097,{"v":5.19561e-83,"d":"5.20E-83"},{"v":2.62135e-82,"d":"2.62E-82"},"down","yes","Arhgap9","protein_coding","chr7:63148900-63157524:+","gi|124248581|ref|NP_001074258.1|",3057,0,"rho GTPase-activating protein 9 isoform 1 [Rattus norvegicus]","gi|124248580|ref|NM_001080789.1|",1954,0,"Rattus norvegicus Rho GTPase activating protein 9 (Arhgap9), transcript variant 1, mRNA","Q9BRR9",553,0,"Rho GTPase-activating protein 9",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0007165|signal transduction;GO:0043087|regulation of GTPase activity;","GO:0005737|cytoplasm;","GO:0005096|GTPase activator activity;GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;","K20634","ARHGAP9; Rho GTPase-activating protein 9"]
["ENSRNOG00000020578",285,18.33417488,942,60.8172718,0.301463291,-1.72994576,{"v":5.29214e-83,"d":"5.29E-83"},{"v":2.6677e-82,"d":"2.67E-82"},"down","yes","Ceacam1","protein_coding","chr1:81043595-81059992:-","gi|76496477|ref|NP_001029032.1|",2769,0,"carcinoembryonic antigen-related cell adhesion molecule 1 isoform 1 precursor [Rattus norvegicus]","gi|76496476|ref|NM_001033860.1|",3573,0,"Rattus norvegicus carcinoembryonic antigen related cell adhesion molecule 1 (Ceacam1), transcript variant 1, mRNA","P16573",1071,0,"Carcinoembryonic antigen-related cell adhesion molecule 1",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0001558|regulation of cell growth;GO:0001568|blood vessel development;GO:0001818|negative regulation of cytokine production;GO:0001915|negative regulation of T cell mediated cytotoxicity;GO:0002639|positive regulation of immunoglobulin production;GO:0002859|negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target;GO:0006469|negative regulation of protein kinase activity;GO:0007155|cell adhesion;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007165|signal transduction;GO:0010594|regulation of endothelial cell migration;GO:0014066|regulation of phosphatidylinositol 3-kinase signaling;GO:0015721|bile acid and bile salt transport;GO:0016338|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;GO:0016339|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0030334|regulation of cell migration;GO:0030853|negative regulation of granulocyte differentiation;GO:0032692|negative regulation of interleukin-1 production;GO:0032703|negative regulation of interleukin-2 production;GO:0032869|cellular response to insulin stimulus;GO:0035726|common myeloid progenitor cell proliferation;GO:0038016|insulin receptor internalization;GO:0038158|granulocyte colony-stimulating factor signaling pathway;GO:0042058|regulation of epidermal growth factor receptor signaling pathway;GO:0042102|positive regulation of T cell proliferation;GO:0042130|negative regulation of T cell proliferation;GO:0043116|negative regulation of vascular permeability;GO:0043318|negative regulation of cytotoxic T cell degranulation;GO:0043406|positive regulation of MAP kinase activity;GO:0044319|wound healing, spreading of cells;GO:0044793|negative regulation by host of viral process;GO:0044794|positive regulation by host of viral process;GO:0044828|negative regulation by host of viral genome replication;GO:0045216|cell-cell junction organization;GO:0045601|regulation of endothelial cell differentiation;GO:0045671|negative regulation of osteoclast differentiation;GO:0045717|negative regulation of fatty acid biosynthetic process;GO:0045779|negative regulation of bone resorption;GO:0046329|negative regulation of JNK cascade;GO:0046330|positive regulation of JNK cascade;GO:0046718|viral entry into host cell;GO:0048541|Peyer's patch development;GO:0050860|negative regulation of T cell receptor signaling pathway;GO:0051055|negative regulation of lipid biosynthetic process;GO:0060312|regulation of blood vessel remodeling;GO:0070237|positive regulation of activation-induced cell death of T cells;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:0070886|positive regulation of calcineurin-NFAT signaling cascade;GO:0090331|negative regulation of platelet aggregation;GO:0098742|cell-cell adhesion via plasma-membrane adhesion molecules;GO:1901143|insulin catabolic process;GO:1903385|regulation of homophilic cell adhesion;GO:1903387|positive regulation of homophilic cell adhesion;GO:1903670|regulation of sprouting angiogenesis;GO:2000346|negative regulation of hepatocyte proliferation;GO:2000516|positive regulation of CD4-positive, alpha-beta T cell activation;GO:2000563|positive regulation of CD4-positive, alpha-beta T cell proliferation;GO:2001187|positive regulation of CD8-positive, alpha-beta T cell activation;GO:2001214|positive regulation of vasculogenesis;","GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005911|cell-cell junction;GO:0005912|adherens junction;GO:0009897|external side of plasma membrane;GO:0009925|basal plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0016328|lateral plasma membrane;GO:0030054|cell junction;GO:0030133|transport vesicle;GO:0031526|brush border membrane;GO:0031528|microvillus membrane;GO:0060170|ciliary membrane;","GO:0001618|virus receptor activity;GO:0003779|actin binding;GO:0005130|granulocyte colony-stimulating factor receptor binding;GO:0005515|protein binding;GO:0005516|calmodulin binding;GO:0015125|bile acid transmembrane transporter activity;GO:0019900|kinase binding;GO:0019901|protein kinase binding;GO:0019903|protein phosphatase binding;GO:0031005|filamin binding;GO:0035325|Toll-like receptor binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0046790|virion binding;GO:0046983|protein dimerization activity;GO:1990782|protein tyrosine kinase binding;","K06499","CEACAM, CD66; carcinoembryonic antigen-related cell adhesion molecule"]
["ENSRNOG00000013886",86,5.532417684,546,35.25077537,0.156944567,-2.671673006,{"v":8.52133e-83,"d":"8.52E-83"},{"v":4.28038E-82,"d":"4.28E-82"},"down","yes","Fyb1","protein_coding","chr2:55632698-55779629:+","gi|564335481|ref|XP_006232081.1|",3301,0,"PREDICTED: FYN-binding protein isoform X4 [Rattus norvegicus]","gi|672041620|ref|XR_590914.1|",3565,0,"PREDICTED: Rattus norvegicus FYN binding protein (Fyb), transcript variant X7, misc_RNA","O35601",1118,0,"FYN-binding protein 1",".",".",".",".","pfam14603","hSH3","Helically-extended SH3 domain. This domain is the 70 C-terminal residues of ADAP - Adhesion and de-granulation promoting adapter protein. It shows homology to SH3 domains; however, conserved residues of the fold are absent. It thus represents an altered SH3 domain fold. An N-terminal, amphipathic, helix makes extensive contacts to residues of the regular SH3 domain fold thereby creating a composite surface with unusual surface properties. The domain can no longer bind conventional proline-rich peptides. There are key phosphorylation sites within the two hSH3 domains and it would appear that binding at these sites does not materially affect the folding of these regions although the equilibrium towards the unfolded state may be slightly altered. The binding partners of the hSH3 domains are still unknown.","GO:0006955|immune response;GO:0007229|integrin-mediated signaling pathway;GO:0050852|T cell receptor signaling pathway;GO:0072659|protein localization to plasma membrane;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0015629|actin cytoskeleton;GO:0030054|cell junction;GO:0032991|protein-containing complex;","GO:0008289|lipid binding;GO:0044877|protein-containing complex binding;","K17698","FYB, ADAP; FYN binding protein"]
["ENSRNOG00000014867",96,6.175722066,568,36.67113628,0.168408255,-2.569965238,{"v":1.45393E-82,"d":"1.45E-82"},{"v":7.29686e-82,"d":"7.30E-82"},"down","yes","Synpo2","protein_coding","chr2:211216783-211371267:-","gi|300794803|ref|NP_001178892.1|",4547,0,"synaptopodin-2 [Rattus norvegicus]","gi|300794802|ref|NM_001191963.1|",3369,0,"Rattus norvegicus synaptopodin 2 (Synpo2), mRNA","D4A702",1756,0,"Synaptopodin-2",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.","GO:0000045|autophagosome assembly;GO:0030335|positive regulation of cell migration;GO:0032233|positive regulation of actin filament bundle assembly;GO:0061684|chaperone-mediated autophagy;GO:2000298|regulation of Rho-dependent protein serine/threonine kinase activity;","GO:0001725|stress fiber;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0005925|focal adhesion;GO:0015629|actin cytoskeleton;GO:0030018|Z disc;GO:0043231|intracellular membrane-bounded organelle;","GO:0003779|actin binding;GO:0030674|protein binding, bridging;GO:0031005|filamin binding;GO:0051371|muscle alpha-actinin binding;GO:0051393|alpha-actinin binding;GO:0071889|14-3-3 protein binding;","K24066","SYNPO2; synaptopodin-2"]
["ENSRNOG00000028353",246,15.82528779,869,56.10425604,0.282069292,-1.825878481,{"v":1.60878e-82,"d":"1.61E-82"},{"v":8.06694e-82,"d":"8.07E-82"},"down","yes","Sox13","protein_coding","chr13:44831085-44875762:-","gi|149058611|gb|EDM09768.1|",2405,0,"SRY (sex determining region Y)-box 13 (predicted), isoform CRA_b [Rattus norvegicus]","gi|157786963|ref|NM_001105952.1|",1654,0,"Rattus norvegicus SRY box 13 (Sox13), mRNA","Q04891",883,0,"Transcription factor SOX-13",".",".",".",".","pfam00505","HMG_box","HMG (high mobility group) box.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0021529|spinal cord oligodendrocyte cell differentiation;GO:0042492|gamma-delta T cell differentiation;GO:0045165|cell fate commitment;GO:0045586|regulation of gamma-delta T cell differentiation;GO:0045588|positive regulation of gamma-delta T cell differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0090336|positive regulation of brown fat cell differentiation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001217|bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0042802|identical protein binding;GO:0043565|sequence-specific DNA binding;","K09269","SOX5_6_13; transcription factor SOX5/6/13 (SOX group D)"]
["ENSRNOG00000050404",443,28.49838412,1207,77.9261646,0.365710083,-1.451227692,{"v":1.8981E-82,"d":"1.90E-82"},{"v":9.50933e-82,"d":"9.51E-82"},"down","yes","Pmepa1","protein_coding","chr3:162012751-162060454:-","gi|564344754|ref|XP_006235751.1|",1186,{"v":6E-158,"d":"6.00E-158"},"PREDICTED: transmembrane prostate androgen-induced protein isoform X1 [Rattus norvegicus]","gi|119508427|ref|NM_022995.3|",1154,0,"Mus musculus prostate transmembrane protein, androgen induced 1 (Pmepa1), mRNA","Q9D7R2",446,{"v":8e-154,"d":"8.00E-154"},"Protein TMEPAI",".",".",".",".","pfam15449","Retinal","Retinal protein. This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.","GO:0008150|biological_process;GO:0010991|negative regulation of SMAD protein complex assembly;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0060394|negative regulation of pathway-restricted SMAD protein phosphorylation;","GO:0000139|Golgi membrane;GO:0005575|cellular_component;GO:0010008|endosome membrane;GO:0016021|integral component of membrane;GO:0031901|early endosome membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0003674|molecular_function;GO:0050699|WW domain binding;GO:0070412|R-SMAD binding;",".","."]
["ENSRNOG00000034025",254,16.3399313,883,57.00812208,0.28662462,-1.80276556,{"v":2.11924e-82,"d":"2.12E-82"},{"v":1.06079e-81,"d":"1.06E-81"},"down","yes","Ptprj","protein_coding","chr3:76405927-76562260:-","gi|309243082|ref|NP_058965.2|",6546,0,"receptor-type tyrosine-protein phosphatase eta [Rattus norvegicus]","gi|309243081|ref|NM_017269.2|",7449,0,"Rattus norvegicus protein tyrosine phosphatase, receptor type, J (Ptprj), mRNA","Q64455",2083,0,"Receptor-type tyrosine-protein phosphatase eta","SPAC11E3.09",151,{"v":2e-38,"d":"2.00E-38"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0001570|vasculogenesis;GO:0001954|positive regulation of cell-matrix adhesion;GO:0006470|protein dephosphorylation;GO:0007507|heart development;GO:0007596|blood coagulation;GO:0008285|negative regulation of cell proliferation;GO:0010572|positive regulation of platelet activation;GO:0010642|negative regulation of platelet-derived growth factor receptor signaling pathway;GO:0010759|positive regulation of macrophage chemotaxis;GO:0030155|regulation of cell adhesion;GO:0030183|B cell differentiation;GO:0030308|negative regulation of cell growth;GO:0030336|negative regulation of cell migration;GO:0032760|positive regulation of tumor necrosis factor production;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0035584|calcium-mediated signaling using intracellular calcium source;GO:0042059|negative regulation of epidermal growth factor receptor signaling pathway;GO:0042593|glucose homeostasis;GO:0043116|negative regulation of vascular permeability;GO:0043407|negative regulation of MAP kinase activity;GO:0043410|positive regulation of MAPK cascade;GO:0045785|positive regulation of cell adhesion;GO:0046627|negative regulation of insulin receptor signaling pathway;GO:0048008|platelet-derived growth factor receptor signaling pathway;GO:0048709|oligodendrocyte differentiation;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050860|negative regulation of T cell receptor signaling pathway;GO:0050918|positive chemotaxis;GO:0051894|positive regulation of focal adhesion assembly;GO:0051897|positive regulation of protein kinase B signaling;GO:0051898|negative regulation of protein kinase B signaling;GO:1905451|positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis;GO:1990264|peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity;GO:2000272|negative regulation of signaling receptor activity;","GO:0001772|immunological synapse;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0032587|ruffle membrane;","GO:0004725|protein tyrosine phosphatase activity;GO:0005161|platelet-derived growth factor receptor binding;GO:0008013|beta-catenin binding;GO:0016791|phosphatase activity;GO:0019901|protein kinase binding;GO:0045295|gamma-catenin binding;GO:0045296|cadherin binding;GO:0051019|mitogen-activated protein kinase binding;GO:0070097|delta-catenin binding;","K05698","PTPRJ, DEP1, CD148; receptor-type tyrosine-protein phosphatase eta [EC:3.1.3.48]"]
["ENSRNOG00000019322",685,44.06635016,1583,102.2014238,0.431171587,-1.213665982,{"v":3.97444e-82,"d":"3.97E-82"},{"v":1.97729e-81,"d":"1.98E-81"},"down","yes","Notch1","protein_coding","chr3:9278086-9323531:-","gi|157787099|ref|NP_001099191.1|",12505,0,"neurogenic locus notch homolog protein 1 precursor [Rattus norvegicus]","gi|157787098|ref|NM_001105721.1|",9396,0,"Rattus norvegicus notch 1 (Notch1), mRNA","Q07008",4806,0,"Neurogenic locus notch homolog protein 1","all2748",89.4,{"v":3e-17,"d":"3.00E-17"},"COG0666","pfam06816","NOD","NOTCH protein. NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001501|skeletal system development;GO:0001701|in utero embryonic development;GO:0001708|cell fate specification;GO:0001837|epithelial to mesenchymal transition;GO:0001889|liver development;GO:0001947|heart looping;GO:0002040|sprouting angiogenesis;GO:0002052|positive regulation of neuroblast proliferation;GO:0002437|inflammatory response to antigenic stimulus;GO:0003151|outflow tract morphogenesis;GO:0003157|endocardium development;GO:0003160|endocardium morphogenesis;GO:0003162|atrioventricular node development;GO:0003169|coronary vein morphogenesis;GO:0003180|aortic valve morphogenesis;GO:0003181|atrioventricular valve morphogenesis;GO:0003182|coronary sinus valve morphogenesis;GO:0003184|pulmonary valve morphogenesis;GO:0003192|mitral valve formation;GO:0003197|endocardial cushion development;GO:0003198|epithelial to mesenchymal transition involved in endocardial cushion formation;GO:0003203|endocardial cushion morphogenesis;GO:0003207|cardiac chamber formation;GO:0003208|cardiac ventricle morphogenesis;GO:0003209|cardiac atrium morphogenesis;GO:0003213|cardiac right atrium morphogenesis;GO:0003214|cardiac left ventricle morphogenesis;GO:0003219|cardiac right ventricle formation;GO:0003222|ventricular trabecula myocardium morphogenesis;GO:0003241|growth involved in heart morphogenesis;GO:0003252|negative regulation of cell proliferation involved in heart valve morphogenesis;GO:0003256|regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation;GO:0003264|regulation of cardioblast proliferation;GO:0003270|Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation;GO:0003273|cell migration involved in endocardial cushion formation;GO:0003332|negative regulation of extracellular matrix constituent secretion;GO:0003344|pericardium morphogenesis;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006606|protein import into nucleus;GO:0006959|humoral immune response;GO:0007219|Notch signaling pathway;GO:0007221|positive regulation of transcription of Notch receptor target;GO:0007283|spermatogenesis;GO:0007368|determination of left/right symmetry;GO:0007386|compartment pattern specification;GO:0007409|axonogenesis;GO:0007417|central nervous system development;GO:0007420|brain development;GO:0007440|foregut morphogenesis;GO:0007492|endoderm development;GO:0007507|heart development;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0008544|epidermis development;GO:0008593|regulation of Notch signaling pathway;GO:0009912|auditory receptor cell fate commitment;GO:0010001|glial cell differentiation;GO:0010467|gene expression;GO:0010468|regulation of gene expression;GO:0010614|negative regulation of cardiac muscle hypertrophy;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010718|positive regulation of epithelial to mesenchymal transition;GO:0010812|negative regulation of cell-substrate adhesion;GO:0010832|negative regulation of myotube differentiation;GO:0014031|mesenchymal cell development;GO:0014807|regulation of somitogenesis;GO:0021515|cell differentiation in spinal cord;GO:0021915|neural tube development;GO:0030154|cell differentiation;GO:0030163|protein catabolic process;GO:0030182|neuron differentiation;GO:0030216|keratinocyte differentiation;GO:0030279|negative regulation of ossification;GO:0030324|lung development;GO:0030326|embryonic limb morphogenesis;GO:0030334|regulation of cell migration;GO:0030335|positive regulation of cell migration;GO:0030513|positive regulation of BMP signaling pathway;GO:0030514|negative regulation of BMP signaling pathway;GO:0030900|forebrain development;GO:0031069|hair follicle morphogenesis;GO:0031100|animal organ regeneration;GO:0031960|response to corticosteroid;GO:0032495|response to muramyl dipeptide;GO:0032496|response to lipopolysaccharide;GO:0035116|embryonic hindlimb morphogenesis;GO:0035148|tube formation;GO:0035914|skeletal muscle cell differentiation;GO:0035924|cellular response to vascular endothelial growth factor stimulus;GO:0042127|regulation of cell proliferation;GO:0042246|tissue regeneration;GO:0043065|positive regulation of apoptotic process;GO:0043086|negative regulation of catalytic activity;GO:0045070|positive regulation of viral genome replication;GO:0045165|cell fate commitment;GO:0045596|negative regulation of cell differentiation;GO:0045603|positive regulation of endothelial cell differentiation;GO:0045607|regulation of inner ear auditory receptor cell differentiation;GO:0045608|negative regulation of inner ear auditory receptor cell differentiation;GO:0045618|positive regulation of keratinocyte differentiation;GO:0045662|negative regulation of myoblast differentiation;GO:0045665|negative regulation of neuron differentiation;GO:0045668|negative regulation of osteoblast differentiation;GO:0045687|positive regulation of glial cell differentiation;GO:0045747|positive regulation of Notch signaling pathway;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0045955|negative regulation of calcium ion-dependent exocytosis;GO:0045967|negative regulation of growth rate;GO:0046427|positive regulation of JAK-STAT cascade;GO:0046533|negative regulation of photoreceptor cell differentiation;GO:0046579|positive regulation of Ras protein signal transduction;GO:0048103|somatic stem cell division;GO:0048663|neuron fate commitment;GO:0048708|astrocyte differentiation;GO:0048709|oligodendrocyte differentiation;GO:0048711|positive regulation of astrocyte differentiation;GO:0048715|negative regulation of oligodendrocyte differentiation;GO:0048754|branching morphogenesis of an epithelial tube;GO:0048845|venous blood vessel morphogenesis;GO:0048873|homeostasis of number of cells within a tissue;GO:0050434|positive regulation of viral transcription;GO:0050678|regulation of epithelial cell proliferation;GO:0050679|positive regulation of epithelial cell proliferation;GO:0050767|regulation of neurogenesis;GO:0050768|negative regulation of neurogenesis;GO:0051726|regulation of cell cycle;GO:0055008|cardiac muscle tissue morphogenesis;GO:0060038|cardiac muscle cell proliferation;GO:0060045|positive regulation of cardiac muscle cell proliferation;GO:0060253|negative regulation of glial cell proliferation;GO:0060271|cilium assembly;GO:0060317|cardiac epithelial to mesenchymal transition;GO:0060354|negative regulation of cell adhesion molecule production;GO:0060411|cardiac septum morphogenesis;GO:0060412|ventricular septum morphogenesis;GO:0060528|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development;GO:0060548|negative regulation of cell death;GO:0060740|prostate gland epithelium morphogenesis;GO:0060768|regulation of epithelial cell proliferation involved in prostate gland development;GO:0060842|arterial endothelial cell differentiation;GO:0060843|venous endothelial cell differentiation;GO:0060948|cardiac vascular smooth muscle cell development;GO:0060956|endocardial cell differentiation;GO:0060979|vasculogenesis involved in coronary vascular morphogenesis;GO:0060982|coronary artery morphogenesis;GO:0061314|Notch signaling involved in heart development;GO:0061384|heart trabecula morphogenesis;GO:0061419|positive regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0062043|positive regulation of cardiac epithelial to mesenchymal transition;GO:0070168|negative regulation of biomineral tissue development;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070986|left/right axis specification;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0072017|distal tubule development;GO:0072044|collecting duct development;GO:0072144|glomerular mesangial cell development;GO:0072538|T-helper 17 type immune response;GO:0090051|negative regulation of cell migration involved in sprouting angiogenesis;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0097150|neuronal stem cell population maintenance;GO:0097400|interleukin-17-mediated signaling pathway;GO:0120163|negative regulation of cold-induced thermogenesis;GO:1901201|regulation of extracellular matrix assembly;GO:1902263|apoptotic process involved in embryonic digit morphogenesis;GO:1902339|positive regulation of apoptotic process involved in morphogenesis;GO:1903849|positive regulation of aorta morphogenesis;GO:2000048|negative regulation of cell-cell adhesion mediated by cadherin;GO:2000737|negative regulation of stem cell differentiation;GO:2000811|negative regulation of anoikis;GO:2000974|negative regulation of pro-B cell differentiation;GO:2001027|negative regulation of endothelial cell chemotaxis;","GO:0001669|acrosomal vesicle;GO:0001726|ruffle;GO:0002193|MAML1-RBP-Jkappa- ICN1 complex;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0005912|adherens junction;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0030027|lamellipodium;GO:0031012|extracellular matrix;GO:0031410|cytoplasmic vesicle;GO:0043235|receptor complex;GO:0071944|cell periphery;","GO:0003682|chromatin binding;GO:0003713|transcription coactivator activity;GO:0004857|enzyme inhibitor activity;GO:0004888|transmembrane signaling receptor activity;GO:0005112|Notch binding;GO:0005509|calcium ion binding;GO:0019899|enzyme binding;GO:0031490|chromatin DNA binding;GO:0042802|identical protein binding;","K02599","NOTCH1; Notch 1"]
["ENSRNOG00000008283",710,45.67461111,1620,104.5902126,0.436700624,-1.195283503,{"v":4.8221e-82,"d":"4.82E-82"},{"v":2.39482e-81,"d":"2.39E-81"},"down","yes","B4galt5","protein_coding","chr3:156018053-156070074:-","gi|7634678|dbj|BAA94791.1|",1784,0,"beta-1,4-galactosyltransferase V [Mus musculus]","gi|157824088|ref|NM_001108608.1|",1417,0,"Rattus norvegicus UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5 (B4galt5), mRNA","Q9JMK0",691,0,"Beta-1,4-galactosyltransferase 5",".",".",".",".","pfam13733","Glyco_transf_7N","N-terminal region of glycosyl transferase group 7. This is the N-terminal half of a family of galactosyltransferases from a wide range of Metazoa with three related galactosyltransferases activities, all three of which are possessed by one sequence in some cases. EC:2.4.1.90, N-acetyllactosamine synthase; EC:2.4.1.38, Beta-N-acetylglucosaminyl-glycopeptide beta-1,4- galactosyltransferase; and EC:2.4.1.22 Lactose synthase. Note that N-acetyllactosamine synthase is a component of Lactose synthase along with alpha-lactalbumin, in the absence of alpha-lactalbumin EC:2.4.1.90 is the catalysed reaction.","GO:0006486|protein glycosylation;GO:0009101|glycoprotein biosynthetic process;GO:0010706|ganglioside biosynthetic process via lactosylceramide;GO:0021955|central nervous system neuron axonogenesis;GO:0022010|central nervous system myelination;GO:0030311|poly-N-acetyllactosamine biosynthetic process;GO:0031647|regulation of protein stability;GO:0040019|positive regulation of embryonic development;GO:0042551|neuron maturation;GO:0070085|glycosylation;","GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;GO:0032580|Golgi cisterna membrane;","GO:0003945|N-acetyllactosamine synthase activity;GO:0008378|galactosyltransferase activity;GO:0008489|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity;","K09905","B4GALT5; beta-1,4-galactosyltransferase 5 [EC:2.4.1.274 2.4.1.-]"]
["ENSRNOG00000020014",40,2.573217527,427,27.56791407,0.093341031,-3.421344784,{"v":6.53887e-82,"d":"6.54E-82"},{"v":3.2418e-81,"d":"3.24E-81"},"down","yes","Myh14","protein_coding","chr1:95096266-95158836:-","gi|162287127|ref|NP_001094160.1|",7316,0,"myosin-14 [Rattus norvegicus]","gi|408821449|ref|NM_001271538.1|",5369,0,"Mus musculus myosin, heavy polypeptide 14 (Myh14), transcript variant 1, mRNA","Q6URW6",2771,0,"Myosin-14","YHR023w",646,0,"COG5022","pfam00063","Myosin_head","Myosin head (motor domain).","GO:0003009|skeletal muscle contraction;GO:0007519|skeletal muscle tissue development;GO:0007605|sensory perception of sound;GO:0008150|biological_process;GO:0019228|neuronal action potential;GO:0030048|actin filament-based movement;GO:0031032|actomyosin structure organization;GO:0070584|mitochondrion morphogenesis;GO:0071625|vocalization behavior;","GO:0001725|stress fiber;GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005903|brush border;GO:0016459|myosin complex;GO:0016460|myosin II complex;GO:0030424|axon;GO:0030426|growth cone;GO:0042641|actomyosin;GO:0097513|myosin II filament;","GO:0000146|microfilament motor activity;GO:0003674|molecular_function;GO:0005524|ATP binding;GO:0051015|actin filament binding;","K10352","MYH9s; myosin heavy chain 9/10/11/14"]
["ENSRNOG00000021814",66,4.24580892,494,31.89355867,0.133124339,-2.909153732,{"v":7.97225e-82,"d":"7.97E-82"},{"v":3.949E-81,"d":"3.95E-81"},"down","yes","Tnfrsf25","protein_coding","chr5:162622075-162626341:+","gi|212549637|ref|NP_001131116.1|",1788,0,"tumor necrosis factor receptor superfamily member 25 precursor [Rattus norvegicus]","gi|212549636|ref|NM_001137644.1|",1626,0,"Rattus norvegicus tumor necrosis factor receptor superfamily, member 25 (Tnfrsf25), mRNA","Q93038",432,{"v":1e-145,"d":"1.00E-145"},"Tumor necrosis factor receptor superfamily member 25",".",".",".",".","pfam00531","Death","Death domain.","GO:0006915|apoptotic process;GO:0007165|signal transduction;","GO:0005886|plasma membrane;",".","K05160","TNFRSF25; tumor necrosis factor receptor superfamily member 25"]
["ENSRNOG00000060949",3,0.192991315,349,22.53208902,0.008565176,-6.867301345,{"v":1.03985E-81,"d":"1.04E-81"},{"v":5.14634e-81,"d":"5.15E-81"},"down","yes","Anxa8","protein_coding","chr16:9397113-9412043:+","gi|72255533|ref|NP_001026824.1|",1459,0,"annexin A8 [Rattus norvegicus]","gi|72255532|ref|NM_001031654.1|",1181,0,"Rattus norvegicus annexin A8 (Anxa8), mRNA","Q4FZU6",566,0,"Annexin A8",".",".",".",".","pfam00191","Annexin","Annexin. This family of annexins also includes giardin that has been shown to function as an annexin.","GO:0007032|endosome organization;GO:0007596|blood coagulation;GO:0008150|biological_process;GO:0016197|endosomal transport;GO:1900004|negative regulation of serine-type endopeptidase activity;GO:1900138|negative regulation of phospholipase A2 activity;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0031902|late endosome membrane;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;GO:0005544|calcium-dependent phospholipid binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;GO:0043325|phosphatidylinositol-3,4-bisphosphate binding;GO:0051015|actin filament binding;","K17096","ANXA8; annexin A8"]
["ENSRNOG00000017671",422,27.14744491,1168,75.40825208,0.360006288,-1.47390599,{"v":1.13627E-81,"d":"1.14E-81"},{"v":5.61867e-81,"d":"5.62E-81"},"down","yes","Rasa3","protein_coding","chr16:75855265-75970804:+","gi|115432015|ref|NP_113762.1|",4323,0,"ras GTPase-activating protein 3 [Rattus norvegicus]","gi|568953189|ref|XM_006508734.1|",2800,0,"PREDICTED: Mus musculus RAS p21 protein activator 3 (Rasa3), transcript variant X1, mRNA","Q9QYJ2",1669,0,"Ras GTPase-activating protein 3",".",".",".",".","pfam00616","RasGAP","GTPase-activator protein for Ras-like GTPase. All alpha-helical domain that accelerates the GTPase activity of Ras, thereby \"switching\" it into an \"off\" position.","GO:0034605|cellular response to heat;GO:0035556|intracellular signal transduction;GO:0043087|regulation of GTPase activity;GO:0046580|negative regulation of Ras protein signal transduction;GO:0051209|release of sequestered calcium ion into cytosol;","GO:0031235|intrinsic component of the cytoplasmic side of the plasma membrane;","GO:0005096|GTPase activator activity;GO:0015278|calcium-release channel activity;GO:0046872|metal ion binding;","K12380","RASA3; Ras GTPase-activating protein 3"]
["ENSRNOG00000000196",365,23.48060994,1071,69.14575169,0.339581382,-1.55817073,{"v":2.6967e-81,"d":"2.70E-81"},{"v":1.32659E-80,"d":"1.33E-80"},"down","yes","Cyp19a1","protein_coding","chr8:54553165-54580758:-","gi|281182626|ref|NP_058781.2|",2553,0,"aromatase [Rattus norvegicus]","gi|281182625|ref|NM_017085.2|",2525,0,"Rattus norvegicus cytochrome P450, family 19, subfamily a, polypeptide 1 (Cyp19a1), mRNA","P22443",963,0,"Aromatase","VNG0422G",97.1,{"v":1e-20,"d":"1.00E-20"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0001553|luteinization;GO:0002677|negative regulation of chronic inflammatory response;GO:0006703|estrogen biosynthetic process;GO:0006710|androgen catabolic process;GO:0008206|bile acid metabolic process;GO:0008207|C21-steroid hormone metabolic process;GO:0008209|androgen metabolic process;GO:0008584|male gonad development;GO:0008585|female gonad development;GO:0009410|response to xenobiotic stimulus;GO:0009635|response to herbicide;GO:0010038|response to metal ion;GO:0010164|response to cesium ion;GO:0010212|response to ionizing radiation;GO:0010760|negative regulation of macrophage chemotaxis;GO:0014070|response to organic cyclic compound;GO:0018879|biphenyl metabolic process;GO:0018894|dibenzo-p-dioxin metabolic process;GO:0018963|phthalate metabolic process;GO:0021766|hippocampus development;GO:0021854|hypothalamus development;GO:0030186|melatonin metabolic process;GO:0030325|adrenal gland development;GO:0030540|female genitalia development;GO:0030851|granulocyte differentiation;GO:0030879|mammary gland development;GO:0032355|response to estradiol;GO:0033574|response to testosterone;GO:0043278|response to morphine;GO:0043627|response to estrogen;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0045779|negative regulation of bone resorption;GO:0050803|regulation of synapse structure or activity;GO:0060065|uterus development;GO:0060348|bone development;GO:0060736|prostate gland growth;GO:0061370|testosterone biosynthetic process;GO:0071333|cellular response to glucose stimulus;GO:0071371|cellular response to gonadotropin stimulus;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0071464|cellular response to hydrostatic pressure;GO:0097720|calcineurin-mediated signaling;GO:2000866|positive regulation of estradiol secretion;","GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;GO:0008021|synaptic vesicle;GO:0016020|membrane;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0043197|dendritic spine;GO:0043679|axon terminus;GO:0045202|synapse;","GO:0005506|iron ion binding;GO:0016712|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0020037|heme binding;GO:0070330|aromatase activity;","K07434","CYP19A; aromatase [EC:1.14.14.14]"]
["ENSRNOG00000049115",100,6.433043818,571,36.86482186,0.174503592,-2.518671365,{"v":3.50181e-81,"d":"3.50E-81"},{"v":1.72116E-80,"d":"1.72E-80"},"down","yes","Ccr5","protein_coding","chr8:123752325-123759260:+","gi|51592090|ref|NP_446412.2|",1670,0,"C-C chemokine receptor type 5 [Rattus norvegicus]","gi|82617607|ref|NM_053960.3|",2492,0,"Rattus norvegicus chemokine (C-C motif) receptor 5 (Ccr5), mRNA","O08556",639,0,"C-C chemokine receptor type 5",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0000165|MAPK cascade;GO:0002437|inflammatory response to antigenic stimulus;GO:0006816|calcium ion transport;GO:0006935|chemotaxis;GO:0006952|defense response;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007267|cell-cell signaling;GO:0007568|aging;GO:0010212|response to ionizing radiation;GO:0010628|positive regulation of gene expression;GO:0014808|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0019722|calcium-mediated signaling;GO:0022409|positive regulation of cell-cell adhesion;GO:0023052|signaling;GO:0030336|negative regulation of cell migration;GO:0030517|negative regulation of axon extension;GO:0030900|forebrain development;GO:0031622|positive regulation of fever generation;GO:0032496|response to lipopolysaccharide;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032755|positive regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0042742|defense response to bacterium;GO:0045444|fat cell differentiation;GO:0045666|positive regulation of neuron differentiation;GO:0050729|positive regulation of inflammatory response;GO:0050900|leukocyte migration;GO:0060139|positive regulation of apoptotic process by virus;GO:0060326|cell chemotaxis;GO:0070098|chemokine-mediated signaling pathway;GO:0070723|response to cholesterol;GO:0070997|neuron death;GO:0071222|cellular response to lipopolysaccharide;GO:2000110|negative regulation of macrophage apoptotic process;GO:2000178|negative regulation of neural precursor cell proliferation;","GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0003779|actin binding;GO:0005515|protein binding;GO:0016493|C-C chemokine receptor activity;GO:0019901|protein kinase binding;GO:0019957|C-C chemokine binding;GO:0042802|identical protein binding;GO:0071791|chemokine (C-C motif) ligand 5 binding;","K04180","CCR5, CD195; C-C chemokine receptor type 5"]
["ENSRNOG00000008030",136,8.748939593,648,41.83608506,0.209124242,-2.257567781,{"v":4.94341e-81,"d":"4.94E-81"},{"v":2.42554e-80,"d":"2.43E-80"},"down","yes","Shc2","protein_coding","chr7:10066705-10088926:+","gi|157820915|ref|NP_001101535.1|",2598,0,"SHC-transforming protein 2 [Rattus norvegicus]","gi|157820914|ref|NM_001108065.1|",3904,0,"Rattus norvegicus SHC (Src homology 2 domain containing) transforming protein 2 (Shc2), mRNA","O70142",1005,0,"SHC-transforming protein 2",".",".",".",".","pfam00640","PID","Phosphotyrosine interaction domain (PTB/PID).","GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0035556|intracellular signal transduction;GO:0043410|positive regulation of MAPK cascade;","GO:0005886|plasma membrane;","GO:0019901|protein kinase binding;GO:0030971|receptor tyrosine kinase binding;","K17447","SHC2; SHC-transforming protein 2"]
["ENSRNOG00000002041",425,27.34043623,1168,75.40825208,0.362565574,-1.463686147,{"v":7.56549E-81,"d":"7.57E-81"},{"v":3.70891e-80,"d":"3.71E-80"},"down","yes","Boc","protein_coding","chr11:56122750-56198059:+","gi|564314432|ref|XP_006221199.1|",5627,0,"PREDICTED: brother of CDO isoform X1 [Rattus norvegicus]","gi|672026053|ref|XM_006221137.2|",4008,0,"PREDICTED: Rattus norvegicus BOC cell adhesion associated, oncogene regulated (Boc), transcript variant X1, mRNA","Q6AZB0",2039,0,"Brother of CDO",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0007224|smoothened signaling pathway;GO:0007411|axon guidance;GO:0030030|cell projection organization;GO:0045663|positive regulation of myoblast differentiation;","GO:0005887|integral component of plasma membrane;GO:0030424|axon;GO:0030426|growth cone;GO:0043025|neuronal cell body;GO:0044295|axonal growth cone;",".","K20020","BOC; brother of CDO"]
["ENSRNOG00000016299",311,20.00676628,976,63.01237502,0.317505351,-1.655147187,{"v":7.68605e-81,"d":"7.69E-81"},{"v":3.76478e-80,"d":"3.76E-80"},"down","yes","Klf4","protein_coding","chr5:70278972-70283602:-","gi|16758530|ref|NP_446165.1|",2136,0,"Krueppel-like factor 4 [Rattus norvegicus]","gi|16758529|ref|NM_053713.1|",2284,0,"Rattus norvegicus Kruppel-like factor 4 (gut) (Klf4), mRNA","Q60793",815,0,"Krueppel-like factor 4",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0002357|defense response to tumor cell;GO:0006351|transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008285|negative regulation of cell proliferation;GO:0009913|epidermal cell differentiation;GO:0010033|response to organic substance;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0014067|negative regulation of phosphatidylinositol 3-kinase signaling;GO:0014740|negative regulation of muscle hyperplasia;GO:0016525|negative regulation of angiogenesis;GO:0019827|stem cell population maintenance;GO:0030154|cell differentiation;GO:0030336|negative regulation of cell migration;GO:0031077|post-embryonic camera-type eye development;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0032270|positive regulation of cellular protein metabolic process;GO:0032526|response to retinoic acid;GO:0032717|negative regulation of interleukin-8 production;GO:0034115|negative regulation of heterotypic cell-cell adhesion;GO:0035166|post-embryonic hemopoiesis;GO:0042127|regulation of cell proliferation;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043433|negative regulation of DNA-binding transcription factor activity;GO:0043551|regulation of phosphatidylinositol 3-kinase activity;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0045444|fat cell differentiation;GO:0045595|regulation of cell differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046985|positive regulation of hemoglobin biosynthetic process;GO:0048662|negative regulation of smooth muscle cell proliferation;GO:0048679|regulation of axon regeneration;GO:0048730|epidermis morphogenesis;GO:0051247|positive regulation of protein metabolic process;GO:0051898|negative regulation of protein kinase B signaling;GO:0051973|positive regulation of telomerase activity;GO:0060070|canonical Wnt signaling pathway;GO:0060761|negative regulation of response to cytokine stimulus;GO:0070301|cellular response to hydrogen peroxide;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0071300|cellular response to retinoic acid;GO:0071363|cellular response to growth factor stimulus;GO:0071407|cellular response to organic cyclic compound;GO:0071409|cellular response to cycloheximide;GO:0071499|cellular response to laminar fluid shear stress;GO:0090051|negative regulation of cell migration involved in sprouting angiogenesis;GO:1901653|cellular response to peptide;GO:1902895|positive regulation of pri-miRNA transcription by RNA polymerase II;GO:1903672|positive regulation of sprouting angiogenesis;GO:1904798|positive regulation of core promoter binding;GO:1904998|negative regulation of leukocyte adhesion to arterial endothelial cell;GO:1990830|cellular response to leukemia inhibitory factor;GO:2000134|negative regulation of G1/S transition of mitotic cell cycle;GO:2000342|negative regulation of chemokine (C-X-C motif) ligand 2 production;","GO:0000785|chromatin;GO:0000791|euchromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005737|cytoplasm;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987|proximal promoter sequence-specific DNA binding;GO:0001010|RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity;GO:0001221|transcription cofactor binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003690|double-stranded DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0008013|beta-catenin binding;GO:0035014|phosphatidylinositol 3-kinase regulator activity;GO:0042826|histone deacetylase binding;GO:0043565|sequence-specific DNA binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;GO:1990837|sequence-specific double-stranded DNA binding;GO:1990841|promoter-specific chromatin binding;","K17846","KLF4; krueppel-like factor 4"]
["ENSRNOG00000012811",34,2.187234898,406,26.21211502,0.083443663,-3.583053695,{"v":8.64643e-81,"d":"8.65E-81"},{"v":4.23157e-80,"d":"4.23E-80"},"down","yes","Spint1","protein_coding","chr3:106231444-106244119:+","gi|67514572|ref|NP_001004265.2|",2544,0,"kunitz-type protease inhibitor 1 precursor [Rattus norvegicus]","gi|67514571|ref|NM_001004265.2|",2289,0,"Rattus norvegicus serine peptidase inhibitor, Kunitz type 1 (Spint1), mRNA","Q9R097",910,0,"Kunitz-type protease inhibitor 1",".",".",".",".","pfam07502","MANEC","MANEC domain. This region of similarity, comprising 8 conserved cysteines, is found in the N-terminal region of several membrane-associated and extracellular proteins. Although formerly called MANSC (for motif at N terminus with seven cysteines) it has now been renamed by MANEC (motif at N terminus with eight cysteines) by Richard Mitter and Stephen Fitzgerald after the discovery of an eighth conserved cysteine. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors.","GO:0001843|neural tube closure;GO:0001892|embryonic placenta development;GO:0010951|negative regulation of endopeptidase activity;GO:0030198|extracellular matrix organization;GO:0045687|positive regulation of glial cell differentiation;GO:0060670|branching involved in labyrinthine layer morphogenesis;GO:0060674|placenta blood vessel development;GO:0071773|cellular response to BMP stimulus;GO:2000178|negative regulation of neural precursor cell proliferation;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004867|serine-type endopeptidase inhibitor activity;","K15619","SPINT1; Kunitz-type protease inhibitor 1"]
["ENSRNOG00000006281",8,0.514643505,335,21.62822298,0.023794997,-5.393197905,{"v":1.18339e-80,"d":"1.18E-80"},{"v":5.78656e-80,"d":"5.79E-80"},"down","yes","Hoxa3","protein_coding","chr4:81269243-81313218:-","gi|564303758|ref|XP_006224990.1|",1598,0,"PREDICTED: homeobox protein Hox-A3 [Rattus norvegicus]","gi|672018319|ref|XM_006224929.2|",2338,0,"PREDICTED: Rattus norvegicus homeobox A3 (Hoxa3), transcript variant X3, mRNA","P02831",605,0,"Homeobox protein Hox-A3",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0001525|angiogenesis;GO:0001974|blood vessel remodeling;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008284|positive regulation of cell proliferation;GO:0009887|animal organ morphogenesis;GO:0009952|anterior/posterior pattern specification;GO:0010159|specification of animal organ position;GO:0010467|gene expression;GO:0021615|glossopharyngeal nerve morphogenesis;GO:0030878|thyroid gland development;GO:0048538|thymus development;GO:0048645|animal organ formation;GO:0048704|embryonic skeletal system morphogenesis;GO:0048706|embryonic skeletal system development;GO:0051216|cartilage development;GO:0060017|parathyroid gland development;","GO:0005634|nucleus;GO:0005654|nucleoplasm;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0071837|HMG box domain binding;","K09303","HOX_3; homeobox protein HoxA/B/D3"]
["ENSRNOG00000015498",24,1.543930516,377,24.33982109,0.063432287,-3.978638832,{"v":1.19011E-80,"d":"1.19E-80"},{"v":5.81446e-80,"d":"5.81E-80"},"down","yes","Il17rb","protein_coding","chr16:5180432-5194125:-","gi|564387882|ref|XP_006252665.1|",1678,0,"PREDICTED: interleukin-17 receptor B isoform X1 [Rattus norvegicus]","gi|672079283|ref|XM_006252603.2|",2512,0,"PREDICTED: Rattus norvegicus interleukin 17 receptor B (Il17rb), transcript variant X1, mRNA","Q9JIP3",582,0,"Interleukin-17 receptor B",".",".",".",".","pfam08357","SEFIR","SEFIR domain. This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain (pfam01582), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways.","GO:0019221|cytokine-mediated signaling pathway;GO:0032736|positive regulation of interleukin-13 production;GO:0032754|positive regulation of interleukin-5 production;GO:0050729|positive regulation of inflammatory response;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0034451|centriolar satellite;GO:0072686|mitotic spindle;","GO:0030368|interleukin-17 receptor activity;","K05165","IL17RB, IL17RH1; interleukin 17 receptor B"]
["ENSRNOG00000016573",176,11.32215712,727,46.93647197,0.241223012,-2.051560555,{"v":1.21307E-80,"d":"1.21E-80"},{"v":5.92156e-80,"d":"5.92E-80"},"down","yes","Dgat2","protein_coding","chr1:153454080-153484428:-","gi|59891415|ref|NP_001012345.1|",1885,0,"diacylglycerol O-acyltransferase 2 [Rattus norvegicus]","gi|59891414|ref|NM_001012345.1|",1998,0,"Rattus norvegicus diacylglycerol O-acyltransferase 2 (Dgat2), mRNA","Q5FVP8",730,0,"Diacylglycerol O-acyltransferase 2",".",".",".",".","pfam03982","DAGAT","Diacylglycerol acyltransferase. The terminal step of triacylglycerol (TAG) formation is catalysed by the enzyme diacylglycerol acyltransferase (DAGAT).","GO:0006071|glycerol metabolic process;GO:0006629|lipid metabolic process;GO:0006640|monoacylglycerol biosynthetic process;GO:0006651|diacylglycerol biosynthetic process;GO:0010867|positive regulation of triglyceride biosynthetic process;GO:0019432|triglyceride biosynthetic process;GO:0019915|lipid storage;GO:0034383|low-density lipoprotein particle clearance;GO:0035336|long-chain fatty-acyl-CoA metabolic process;GO:0035356|cellular triglyceride homeostasis;GO:0038183|bile acid signaling pathway;GO:0042572|retinol metabolic process;GO:0042632|cholesterol homeostasis;GO:0045722|positive regulation of gluconeogenesis;GO:0046322|negative regulation of fatty acid oxidation;GO:0046339|diacylglycerol metabolic process;GO:0050746|regulation of lipoprotein metabolic process;GO:0055089|fatty acid homeostasis;GO:0060613|fat pad development;GO:0071400|cellular response to oleic acid;GO:0090181|regulation of cholesterol metabolic process;GO:0097006|regulation of plasma lipoprotein particle levels;","GO:0005739|mitochondrion;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005811|lipid droplet;GO:0005829|cytosol;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030176|integral component of endoplasmic reticulum membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0048471|perinuclear region of cytoplasm;GO:1990578|perinuclear endoplasmic reticulum membrane;","GO:0003846|2-acylglycerol O-acyltransferase activity;GO:0004144|diacylglycerol O-acyltransferase activity;GO:0008374|O-acyltransferase activity;GO:0016747|transferase activity, transferring acyl groups other than amino-acyl groups;GO:0042803|protein homodimerization activity;GO:0050252|retinol O-fatty-acyltransferase activity;","K11160","DGAT2; diacylglycerol O-acyltransferase 2 [EC:2.3.1.20 2.3.1.75]"]
["ENSRNOG00000017684",69,4.438800235,496,32.02268239,0.138614254,-2.850852473,{"v":1.54663E-80,"d":"1.55E-80"},{"v":7.53052e-80,"d":"7.53E-80"},"down","yes","Fbxl22","protein_coding","chr8:67069998-67076685:-","gi|157817364|ref|NP_001102239.1|",1226,{"v":9e-154,"d":"9.00E-154"},"F-box and leucine-rich protein 22 [Rattus norvegicus]","gi|157817363|ref|NM_001108769.1|",4460,0,"Rattus norvegicus F-box and leucine-rich repeat protein 22 (Fbxl22), mRNA","Q8C7B6",434,{"v":3e-139,"d":"3.00E-139"},"F-box and leucine-rich protein 22",".",".",".",".","pfam12937","F-box-like","F-box-like. This is an F-box-like family.","GO:0000086|G2/M transition of mitotic cell cycle;GO:0016567|protein ubiquitination;GO:0031146|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0043153|entrainment of circadian clock by photoperiod;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051726|regulation of cell cycle;","GO:0005634|nucleus;GO:0005730|nucleolus;GO:0005829|cytosol;GO:0019005|SCF ubiquitin ligase complex;GO:0030018|Z disc;","GO:0061630|ubiquitin protein ligase activity;","K10288","FBXL22; F-box and leucine-rich repeat protein 22"]
["ENSRNOG00000016366",799,51.40002011,1741,112.4021977,0.457286612,-1.128829414,{"v":1.65169E-80,"d":"1.65E-80"},{"v":8.03517e-80,"d":"8.04E-80"},"down","yes","Colec12","protein_coding","chr18:732950-920618:+","gi|71043880|ref|NP_001020892.1|",2073,0,"collectin-12 [Rattus norvegicus]","gi|71043879|ref|NM_001025721.1|",2887,0,"Rattus norvegicus collectin sub-family member 12 (Colec12), mRNA","Q4V885",803,0,"Collectin-12",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0006910|phagocytosis, recognition;GO:0006955|immune response;GO:0034138|toll-like receptor 3 signaling pathway;GO:0042742|defense response to bacterium;GO:0060355|positive regulation of cell adhesion molecule production;GO:0071360|cellular response to exogenous dsRNA;","GO:0005581|collagen trimer;GO:0016021|integral component of membrane;","GO:0005044|scavenger receptor activity;GO:0030169|low-density lipoprotein particle binding;GO:0030246|carbohydrate binding;GO:0038023|signaling receptor activity;GO:0038187|pattern recognition receptor activity;GO:0046872|metal ion binding;","K10062","COLEC12; collectin sub-family member 12"]
["ENSRNOG00000032339",301,19.36346189,956,61.72113783,0.313724966,-1.672427751,{"v":2.24834e-80,"d":"2.25E-80"},{"v":1.09192e-79,"d":"1.09E-79"},"down","yes","Rasl12","protein_coding","chr8:65917840-65932741:+","gi|157823221|ref|NP_001101632.1|",1412,0,"ras-like protein family member 12 [Rattus norvegicus]","gi|157823220|ref|NM_001108162.1|",2446,0,"Rattus norvegicus RAS-like, family 12 (Rasl12), mRNA","Q08AT1",541,0,"Ras-like protein family member 12","SPAC17H9.09c",100,{"v":1E-22,"d":"1.00E-22"},"COG1100","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0007165|signal transduction;","GO:0005886|plasma membrane;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0019003|GDP binding;","K07854","RASL12, RIS; Ras-like protein family member 12"]
["ENSRNOG00000021243",62,3.988487167,478,30.86056892,0.129242179,-2.951851117,{"v":2.36191E-80,"d":"2.36E-80"},{"v":1.1461e-79,"d":"1.15E-79"},"down","yes","Siglec1","protein_coding","chr3:118287988-118306850:-","gi|564343027|ref|XP_006235086.1|",8540,0,"PREDICTED: sialoadhesin isoform X1 [Rattus norvegicus]","gi|672046902|ref|XM_006235024.2|",6172,0,"PREDICTED: Rattus norvegicus sialic acid binding Ig-like lectin 1, sialoadhesin (Siglec1), transcript variant X1, mRNA","Q62230",2862,0,"Sialoadhesin",".",".",".",".","pfam08205","C2-set_2","CD80-like C2-set immunoglobulin domain. These domains belong to the immunoglobulin superfamily.","GO:0046718|viral entry into host cell;GO:0050765|negative regulation of phagocytosis;GO:0070234|positive regulation of T cell apoptotic process;GO:0072583|clathrin-dependent endocytosis;GO:0075512|clathrin-dependent endocytosis of virus by host cell;GO:2001238|positive regulation of extrinsic apoptotic signaling pathway;","GO:0005769|early endosome;GO:0005770|late endosome;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030139|endocytic vesicle;","GO:0030246|carbohydrate binding;GO:0046790|virion binding;","K06548","SN, SIGLEC1, CD169; sialoadhesin"]
["ENSRNOG00000020401",630,40.52817606,1485,95.87436159,0.422721731,-1.242219817,{"v":5.75489e-80,"d":"5.75E-80"},{"v":2.78778e-79,"d":"2.79E-79"},"down","yes","Adcy4","protein_coding","chr15:29266287-29282108:-","gi|126723574|ref|NP_062158.2|",5064,0,"adenylate cyclase type 4 [Rattus norvegicus]","gi|126723573|ref|NM_019285.2|",3415,0,"Rattus norvegicus adenylate cyclase 4 (Adcy4), mRNA","P26770",1931,0,"Adenylate cyclase type 4","all0661",154,{"v":1e-38,"d":"1.00E-38"},"COG2114","pfam00211","Guanylate_cyc","Adenylate and Guanylate cyclase catalytic domain.","GO:0006171|cAMP biosynthetic process;GO:0007188|adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0035556|intracellular signal transduction;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0032991|protein-containing complex;","GO:0004016|adenylate cyclase activity;GO:0005080|protein kinase C binding;GO:0005524|ATP binding;GO:0031683|G-protein beta/gamma-subunit complex binding;GO:0046872|metal ion binding;","K08044","ADCY4; adenylate cyclase 4 [EC:4.6.1.1]"]
["ENSRNOG00000017786",21,1.350939202,365,23.56507877,0.057328016,-4.12461585,{"v":8.46069e-80,"d":"8.46E-80"},{"v":4.08812e-79,"d":"4.09E-79"},"down","yes","Acta1","protein_coding","chr19:51883715-51886742:-","gi|625184696|ref|XP_007651673.1|",2064,0,"PREDICTED: actin, alpha skeletal muscle [Cricetulus griseus]","gi|298892557|emb|FQ215282.1|",1445,0,"Rattus norvegicus TL0ACA48YN09 mRNA sequence","P68136",790,0,"Actin, alpha skeletal muscle","SPBC32H8.12c",711,0,"COG5277","pfam00022","Actin","Actin.","GO:0009612|response to mechanical stimulus;GO:0009991|response to extracellular stimulus;GO:0010226|response to lithium ion;GO:0010628|positive regulation of gene expression;GO:0030240|skeletal muscle thin filament assembly;GO:0043503|skeletal muscle fiber adaptation;GO:0048545|response to steroid hormone;GO:0048741|skeletal muscle fiber development;GO:0071417|cellular response to organonitrogen compound;GO:0090131|mesenchyme migration;","GO:0001725|stress fiber;GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005865|striated muscle thin filament;GO:0005869|dynactin complex;GO:0005884|actin filament;GO:0015629|actin cytoskeleton;GO:0030017|sarcomere;GO:0030027|lamellipodium;GO:0030175|filopodium;GO:0044297|cell body;","GO:0005524|ATP binding;","K10354","ACTA1; actin, alpha skeletal muscle"]
["ENSRNOG00000008478",37,2.380226213,410,26.47036246,0.089920424,-3.475207353,{"v":1.06958E-79,"d":"1.07E-79"},{"v":5.15938e-79,"d":"5.16E-79"},"down","yes","Mmp13","protein_coding","chr8:4497960-4508239:+","gi|213972541|ref|NP_598214.1|",2448,0,"collagenase 3 precursor [Rattus norvegicus]","gi|213972540|ref|NM_133530.1|",2602,0,"Rattus norvegicus matrix metallopeptidase 13 (Mmp13), mRNA","P23097",932,0,"Collagenase 3 (Fragment)",".",".",".",".","pfam00413","Peptidase_M10","Matrixin. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.","GO:0001503|ossification;GO:0001554|luteolysis;GO:0001649|osteoblast differentiation;GO:0001666|response to hypoxia;GO:0001958|endochondral ossification;GO:0003417|growth plate cartilage development;GO:0006508|proteolysis;GO:0007507|heart development;GO:0007567|parturition;GO:0009410|response to xenobiotic stimulus;GO:0009612|response to mechanical stimulus;GO:0009725|response to hormone;GO:0022617|extracellular matrix disassembly;GO:0030198|extracellular matrix organization;GO:0030282|bone mineralization;GO:0030574|collagen catabolic process;GO:0035116|embryonic hindlimb morphogenesis;GO:0043171|peptide catabolic process;GO:0043627|response to estrogen;GO:0044267|cellular protein metabolic process;GO:0044849|estrous cycle;GO:0051216|cartilage development;GO:0060349|bone morphogenesis;GO:0071498|cellular response to fluid shear stress;GO:1904244|positive regulation of pancreatic trypsinogen secretion;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005764|lysosome;GO:0005794|Golgi apparatus;GO:0031012|extracellular matrix;GO:0046581|intercellular canaliculus;","GO:0001968|fibronectin binding;GO:0004175|endopeptidase activity;GO:0004222|metalloendopeptidase activity;GO:0004252|serine-type endopeptidase activity;GO:0005509|calcium ion binding;GO:0005518|collagen binding;GO:0008233|peptidase activity;GO:0008270|zinc ion binding;GO:0048306|calcium-dependent protein binding;GO:0050750|low-density lipoprotein particle receptor binding;","K07994","MMP13; matrix metalloproteinase-13 (collagenase 3) [EC:3.4.24.-]"]
["ENSRNOG00000009331",78,5.017774178,513,33.120234,0.151501773,-2.722593416,{"v":1.88871e-79,"d":"1.89E-79"},{"v":9.08761e-79,"d":"9.09E-79"},"down","yes","Hck","protein_coding","chr3:141571587-141614693:+","gi|34734058|ref|NP_037317.2|",2793,0,"tyrosine-protein kinase HCK [Rattus norvegicus]","gi|319918868|ref|NM_013185.3|",2054,0,"Rattus norvegicus hemopoietic cell kinase (Hck), mRNA","P50545",1080,0,"Tyrosine-protein kinase HCK","YAR019c",109,{"v":7e-24,"d":"7.00E-24"},"COG0515","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0006887|exocytosis;GO:0006909|phagocytosis;GO:0006954|inflammatory response;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0008284|positive regulation of cell proliferation;GO:0008360|regulation of cell shape;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0030154|cell differentiation;GO:0043066|negative regulation of apoptotic process;GO:0045087|innate immune response;GO:0046777|protein autophosphorylation;GO:0050764|regulation of phagocytosis;GO:0050830|defense response to Gram-positive bacterium;GO:0051090|regulation of DNA-binding transcription factor activity;GO:0071801|regulation of podosome assembly;GO:2000251|positive regulation of actin cytoskeleton reorganization;","GO:0005634|nucleus;GO:0005764|lysosome;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0005901|caveola;GO:0005925|focal adhesion;GO:0030133|transport vesicle;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0042995|cell projection;GO:0043231|intracellular membrane-bounded organelle;","GO:0001784|phosphotyrosine residue binding;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0005102|signaling receptor binding;GO:0005524|ATP binding;","K08893","HCK; hemopoietic cell kinase [EC:2.7.10.2]"]
["ENSRNOG00000008758",122,7.848313459,611,39.44729625,0.198956943,-2.329471852,{"v":2.18462E-79,"d":"2.18E-79"},{"v":1.04937E-78,"d":"1.05E-78"},"down","yes","Tspan18","protein_coding","chr3:79161662-79299852:-","gi|157820381|ref|NP_001101220.1|",1129,{"v":7e-147,"d":"7.00E-147"},"tetraspanin-18 [Rattus norvegicus]","gi|672046289|ref|XM_006234574.2|",2138,0,"PREDICTED: Rattus norvegicus tetraspanin 18 (Tspan18), transcript variant X2, mRNA","Q80WR1",438,{"v":4e-148,"d":"4.00E-148"},"Tetraspanin-18",".",".",".",".","pfam00335","Tetraspannin","Tetraspanin family.",".","GO:0005887|integral component of plasma membrane;",".","K17353","TSPAN18; tetraspanin-18"]
["ENSRNOG00000001312",99,6.36871338,560,36.15464141,0.176152027,-2.505107016,{"v":3.50543e-79,"d":"3.51E-79"},{"v":1.6824e-78,"d":"1.68E-78"},"down","yes","Pdgfa","protein_coding","chr12:15645541-15666497:+","gi|564378363|ref|XP_006248981.1|",880,{"v":1e-113,"d":"1.00E-113"},"PREDICTED: platelet-derived growth factor subunit A isoform X1 [Rattus norvegicus]","gi|38197601|gb|BC061731.1|",1372,0,"Rattus norvegicus platelet-derived growth factor alpha polypeptide, mRNA (cDNA clone MGC:72268 IMAGE:5598667), complete cds","P28576",343,{"v":4e-115,"d":"4.00E-115"},"Platelet-derived growth factor subunit A",".",".",".",".","pfam04692","PDGF_N","Platelet-derived growth factor, N terminal region. This family consists of the amino terminal regions of platelet-derived growth factor (PDGF, pfam00341) A and B chains.","GO:0001525|angiogenesis;GO:0001666|response to hypoxia;GO:0001942|hair follicle development;GO:0002053|positive regulation of mesenchymal cell proliferation;GO:0008284|positive regulation of cell proliferation;GO:0008584|male gonad development;GO:0009410|response to xenobiotic stimulus;GO:0009611|response to wounding;GO:0009887|animal organ morphogenesis;GO:0010033|response to organic substance;GO:0010035|response to inorganic substance;GO:0010512|negative regulation of phosphatidylinositol biosynthetic process;GO:0010544|negative regulation of platelet activation;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0014910|regulation of smooth muscle cell migration;GO:0030031|cell projection assembly;GO:0030036|actin cytoskeleton organization;GO:0030335|positive regulation of cell migration;GO:0031954|positive regulation of protein autophosphorylation;GO:0032355|response to estradiol;GO:0032526|response to retinoic acid;GO:0035793|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway;GO:0042060|wound healing;GO:0043406|positive regulation of MAP kinase activity;GO:0043410|positive regulation of MAPK cascade;GO:0043588|skin development;GO:0048008|platelet-derived growth factor receptor signaling pathway;GO:0048146|positive regulation of fibroblast proliferation;GO:0048286|lung alveolus development;GO:0048565|digestive tract development;GO:0048839|inner ear development;GO:0050730|regulation of peptidyl-tyrosine phosphorylation;GO:0050919|negative chemotaxis;GO:0051781|positive regulation of cell division;GO:0051897|positive regulation of protein kinase B signaling;GO:0060348|bone development;GO:0060683|regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:1990401|embryonic lung development;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005902|microvillus;GO:0009986|cell surface;GO:0016020|membrane;","GO:0005161|platelet-derived growth factor receptor binding;GO:0005518|collagen binding;GO:0008083|growth factor activity;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0046982|protein heterodimerization activity;GO:0048407|platelet-derived growth factor binding;GO:0070851|growth factor receptor binding;","K04359","PDGFA; platelet-derived growth factor subunit A"]
["ENSRNOG00000000187",102,6.561704695,565,36.47745071,0.179883862,-2.474862335,{"v":8.39987e-79,"d":"8.40E-79"},{"v":4.01794e-78,"d":"4.02E-78"},"down","yes","Csf2rb","protein_coding","chr7:109886425-109904157:+","gi|149066007|gb|EDM15880.1|",4115,0,"rCG59972 [Rattus norvegicus]","gi|19424231|ref|NM_133555.1|",2843,0,"Rattus norvegicus colony stimulating factor 2 receptor beta common subunit (Csf2rb), mRNA","P26955",1258,0,"Cytokine receptor common subunit beta",".",".",".",".","pfam09294","Interfer-bind","Interferon-alpha/beta receptor, fibronectin type III. Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.","GO:0019221|cytokine-mediated signaling pathway;GO:0032496|response to lipopolysaccharide;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0004896|cytokine receptor activity;","K04738","CSF2RB, IL3RB, CD131; cytokine receptor common subunit beta"]
["ENSRNOG00000003622",112,7.205009077,585,37.7686879,0.19076673,-2.390118512,{"v":2.22943e-78,"d":"2.23E-78"},{"v":1.06197e-77,"d":"1.06E-77"},"down","yes","ENSRNOG00000003622","protein_coding","chrX:13359430-13392586:-","gi|16876540|gb|AAG31606.3|AF298656_1",2861,0,"NADPH oxidase beta subunit gp91phox [Rattus norvegicus]","gi|298891875|emb|FQ217794.1|",2923,0,"Rattus norvegicus TL0ACA17YL01 mRNA sequence","Q61093",1075,0,"Cytochrome b-245 heavy chain",".",".",".",".","pfam08030","NAD_binding_6","Ferric reductase NAD binding domain.","GO:0006801|superoxide metabolic process;GO:0006952|defense response;GO:0006954|inflammatory response;GO:0007584|response to nutrient;GO:0009410|response to xenobiotic stimulus;GO:0022900|electron transport chain;GO:0032760|positive regulation of tumor necrosis factor production;GO:0042554|superoxide anion generation;GO:0045087|innate immune response;GO:0045730|respiratory burst;GO:0045766|positive regulation of angiogenesis;GO:0050665|hydrogen peroxide biosynthetic process;GO:0071276|cellular response to cadmium ion;GO:0071361|cellular response to ethanol;GO:0071456|cellular response to hypoxia;GO:0097411|hypoxia-inducible factor-1alpha signaling pathway;GO:1904044|response to aldosterone;GO:1904845|cellular response to L-glutamine;GO:1990776|response to angiotensin;","GO:0005635|nuclear envelope;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005791|rough endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0030425|dendrite;GO:0043020|NADPH oxidase complex;GO:0043025|neuronal cell body;GO:0045335|phagocytic vesicle;GO:0097038|perinuclear endoplasmic reticulum;","GO:0005515|protein binding;GO:0009055|electron transfer activity;GO:0016175|superoxide-generating NADPH oxidase activity;GO:0020037|heme binding;GO:0046982|protein heterodimerization activity;GO:0050660|flavin adenine dinucleotide binding;","K21421","NOX2, GP91, CYBB; NADPH oxidase 2 [EC:1.-.-.-]"]
["ENSRNOG00000012681",213,13.70238333,786,50.74562169,0.270020996,-1.888856501,{"v":2.98781e-78,"d":"2.99E-78"},{"v":1.42084e-77,"d":"1.42E-77"},"down","yes","Lgals9","protein_coding","chr10:63907018-63930045:-","gi|149053566|gb|EDM05383.1|",1769,0,"rCG33388, isoform CRA_a [Rattus norvegicus]","gi|2351552|gb|U72741.1|RNU72741",1067,0,"Rattus norvegicus 36 Kd beta-galactoside binding lectin mRNA, complete cds","P97840",682,0,"Galectin-9",".",".",".",".","pfam00337","Gal-bind_lectin","Galactoside-binding lectin. This family contains galactoside binding lectins.   The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).","GO:0001819|positive regulation of cytokine production;GO:0002519|natural killer cell tolerance induction;GO:0006811|ion transport;GO:0006954|inflammatory response;GO:0007565|female pregnancy;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0032496|response to lipopolysaccharide;GO:0032682|negative regulation of chemokine production;GO:0032689|negative regulation of interferon-gamma production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032722|positive regulation of chemokine production;GO:0032729|positive regulation of interferon-gamma production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032732|positive regulation of interleukin-1 production;GO:0032733|positive regulation of interleukin-10 production;GO:0032735|positive regulation of interleukin-12 production;GO:0032736|positive regulation of interleukin-13 production;GO:0032753|positive regulation of interleukin-4 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032815|negative regulation of natural killer cell activation;GO:0032823|regulation of natural killer cell differentiation;GO:0032834|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response;GO:0034138|toll-like receptor 3 signaling pathway;GO:0038066|p38MAPK cascade;GO:0043032|positive regulation of macrophage activation;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043305|negative regulation of mast cell degranulation;GO:0043322|negative regulation of natural killer cell degranulation;GO:0045089|positive regulation of innate immune response;GO:0045185|maintenance of protein location;GO:0045591|positive regulation of regulatory T cell differentiation;GO:0045953|negative regulation of natural killer cell mediated cytotoxicity;GO:0046007|negative regulation of activated T cell proliferation;GO:0046598|positive regulation of viral entry into host cell;GO:0050728|negative regulation of inflammatory response;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051353|positive regulation of oxidoreductase activity;GO:0060135|maternal process involved in female pregnancy;GO:0070241|positive regulation of activated T cell autonomous cell death;GO:0070371|ERK1 and ERK2 cascade;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070555|response to interleukin-1;GO:0071346|cellular response to interferon-gamma;GO:0071636|positive regulation of transforming growth factor beta production;GO:0071639|positive regulation of monocyte chemotactic protein-1 production;GO:0071902|positive regulation of protein serine/threonine kinase activity;GO:0098586|cellular response to virus;GO:1900426|positive regulation of defense response to bacterium;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:2000406|positive regulation of T cell migration;GO:2000510|positive regulation of dendritic cell chemotaxis;GO:2000562|negative regulation of CD4-positive, alpha-beta T cell proliferation;GO:2000563|positive regulation of CD4-positive, alpha-beta T cell proliferation;GO:2000670|positive regulation of dendritic cell apoptotic process;GO:2000679|positive regulation of transcription regulatory region DNA binding;GO:2001190|positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:2001200|positive regulation of dendritic cell differentiation;GO:2001269|positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0005102|signaling receptor binding;GO:0016936|galactoside binding;GO:0019899|enzyme binding;GO:0030246|carbohydrate binding;GO:0043539|protein serine/threonine kinase activator activity;GO:0048030|disaccharide binding;","K10093","LGALS9; galectin-9"]
["ENSRNOG00000014237",380,24.44556651,1077,69.53312285,0.351567217,-1.508127546,{"v":5.29759e-78,"d":"5.30E-78"},{"v":2.51506E-77,"d":"2.52E-77"},"down","yes","Zfp503","protein_coding","chr15:2313060-2316848:+","gi|157822185|ref|NP_001100720.1|",1800,0,"zinc finger protein 503 [Rattus norvegicus]","gi|157822184|ref|NM_001107250.1|",3101,0,"Rattus norvegicus zinc finger protein 503 (Zfp503), mRNA","Q7TMA2",688,0,"Zinc finger protein 503",".",".",".",".","pfam12402","nlz1","NocA-like zinc-finger protein 1. This domain family is found in eukaryotes, and is typically between 42 and 57 amino acids in length. There is a conserved GAY sequence motif. There is a single completely conserved residue G that may be functionally important. Nlz1 self-associated via its C terminus, interacted with Nlz2, and bound to histone deacetylases.","GO:0008285|negative regulation of cell proliferation;GO:0010629|negative regulation of gene expression;GO:0045892|negative regulation of transcription, DNA-templated;GO:0061351|neural precursor cell proliferation;GO:0070315|G1 to G0 transition involved in cell differentiation;","GO:0005634|nucleus;",".",".","."]
["ENSRNOG00000002907",188,12.09412238,735,47.45296685,0.254865463,-1.972192207,{"v":1.60951E-77,"d":"1.61E-77"},{"v":7.62224e-77,"d":"7.62E-77"},"down","yes","Plekha6","protein_coding","chr13:44615011-44754673:+","gi|564315753|ref|XP_006221522.1|",5632,0,"PREDICTED: pleckstrin homology domain-containing family A member 6 isoform X1 [Rattus norvegicus]","gi|672073961|ref|XM_006249816.2|",5191,0,"PREDICTED: Rattus norvegicus pleckstrin homology domain containing, family A member 6 (Plekha6), transcript variant X9, mRNA","Q7TQG1",2054,0,"Pleckstrin homology domain-containing family A member 6",".",".",".",".","pfam00169","PH","PH domain. PH stands for pleckstrin homology.",".",".",".","K23797","PLEKHA4_5_6_7; pleckstrin homology domain-containing family A member 4/5/6/7"]
["ENSRNOG00000004444",22,1.41526964,358,23.11314576,0.061232238,-4.029564778,{"v":2.88753e-77,"d":"2.89E-77"},{"v":1.3652E-76,"d":"1.37E-76"},"down","yes","Ikzf1","protein_coding","chr14:86255065-86342416:+","gi|672076803|ref|XP_008768537.1|",2281,0,"PREDICTED: DNA-binding protein Ikaros isoform X6 [Rattus norvegicus]","gi|672076802|ref|XM_008770315.1|",1830,0,"PREDICTED: Rattus norvegicus IKAROS family zinc finger 1 (Ikzf1), transcript variant X11, mRNA","Q03267",736,0,"DNA-binding protein Ikaros",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001779|natural killer cell differentiation;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0010628|positive regulation of gene expression;GO:0030097|hemopoiesis;GO:0030098|lymphocyte differentiation;GO:0030183|B cell differentiation;GO:0030217|T cell differentiation;GO:0030218|erythrocyte differentiation;GO:0030900|forebrain development;GO:0032968|positive regulation of transcription elongation from RNA polymerase II promoter;GO:0035881|amacrine cell differentiation;GO:0040018|positive regulation of multicellular organism growth;GO:0045184|establishment of protein localization;GO:0045660|positive regulation of neutrophil differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045899|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048535|lymph node development;GO:0048538|thymus development;GO:0048541|Peyer's patch development;GO:0048732|gland development;GO:0051138|positive regulation of NK T cell differentiation;GO:0060040|retinal bipolar neuron differentiation;GO:0060041|retina development in camera-type eye;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005721|pericentric heterochromatin;GO:0005829|cytosol;GO:0032991|protein-containing complex;GO:0032993|protein-DNA complex;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0008187|poly-pyrimidine tract binding;GO:0019904|protein domain specific binding;GO:0042802|identical protein binding;GO:0043565|sequence-specific DNA binding;","K09220","IKZF, ZNFN1A; IKAROS family zinc finger protein"]
["ENSRNOG00000063679",240,15.43930516,830,53.58634351,0.288120147,-1.79525755,{"v":3.91289e-77,"d":"3.91E-77"},{"v":1.84845e-76,"d":"1.85E-76"},"down","yes","ENSRNOG00000063679","protein_coding","chr4:31361669-31376415:-","gi|672018010|ref|XP_008773891.1|",8341,0,"PREDICTED: LOW QUALITY PROTEIN: sterile alpha motif domain-containing protein 9-like isoform X1 [Rattus norvegicus]","gi|672018009|ref|XM_008775669.1|",5182,0,"PREDICTED: Rattus norvegicus sterile alpha motif domain-containing protein 9-like (LOC103690031), transcript variant X1, mRNA","Q69Z37",2834,0,"Sterile alpha motif domain-containing protein 9-like",".",".",".",".","pfam09235","Ste50p-SAM","Ste50p, sterile alpha motif. The fungal Ste50p SAM domain consists of five helices, which form a compact, globular fold. It is required for mediation of homodimerization and heterodimerization (and in some cases oligomerization) of the protein.",".",".",".",".","."]
["ENSRNOG00000021833",12,0.771965258,329,21.24085183,0.036343423,-4.782161892,{"v":4.72289e-77,"d":"4.72E-77"},{"v":2.2274E-76,"d":"2.23E-76"},"down","yes","Myrfl","protein_coding","chr7:52403650-52519907:-","gi|672021719|ref|XP_008774669.1|",4459,0,"PREDICTED: myelin regulatory factor-like protein isoform X1 [Rattus norvegicus]","gi|672021718|ref|XM_008776447.1|",2679,0,"PREDICTED: Rattus norvegicus myelin regulatory factor-like (Myrfl), transcript variant X1, mRNA","Q3UN70",1568,0,"Myelin regulatory factor-like protein",".",".",".",".","pfam13888","MRF_C2","Myelin gene regulatory factor C-terminal domain 2. This domain is found further downstream of Peptidase_S74, pfam13884, and MRF_C1, pfam13887. The function is not known.","GO:0016540|protein autoprocessing;GO:0045893|positive regulation of transcription, DNA-templated;","GO:0005634|nucleus;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0003700|DNA-binding transcription factor activity;GO:0043565|sequence-specific DNA binding;",".","."]
["ENSRNOG00000049385",256,16.46859218,858,55.39407558,0.2972988,-1.750014457,{"v":5.71544e-77,"d":"5.72E-77"},{"v":2.69329E-76,"d":"2.69E-76"},"down","yes","Adamtsl4","protein_coding","chr2:183235646-183246848:-","gi|672043433|ref|XP_008759529.1|",4953,0,"PREDICTED: ADAMTS-like protein 4 isoform X3 [Rattus norvegicus]","gi|77404406|ref|NM_001034012.1|",4150,0,"Rattus norvegicus ADAMTS-like 4 (Adamtsl4), mRNA","Q4FZU4",1885,0,"ADAMTS-like protein 4",".",".",".",".","pfam05986","ADAM_spacer1","ADAM-TS Spacer 1. This family represents the Spacer-1 region from the ADAM-TS family of metalloproteinases.","GO:0002064|epithelial cell development;GO:0006915|apoptotic process;GO:0030198|extracellular matrix organization;GO:0043065|positive regulation of apoptotic process;","GO:0005576|extracellular region;GO:0005614|interstitial matrix;GO:0031012|extracellular matrix;","GO:0002020|protease binding;GO:0042802|identical protein binding;","K23369","ADAMTSL4; ADAMTS-like protein 4"]
["ENSRNOG00000012019",426,27.40476667,1146,73.98789116,0.370395294,-1.432862328,{"v":6.27439e-77,"d":"6.27E-77"},{"v":2.95181e-76,"d":"2.95E-76"},"down","yes","B3galnt1","protein_coding","chr2:153846474-153877332:-","gi|61557130|ref|NP_001013176.1|",1673,0,"UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 [Rattus norvegicus]","gi|61557129|ref|NM_001013158.1|",1803,0,"Rattus norvegicus beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) (B3galnt1), mRNA","Q6AY39",649,0,"UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1",".",".",".",".","pfam01762","Galactosyl_T","Galactosyltransferase. This family includes the galactosyltransferases UDP-galactose:2-acetamido-2-deoxy-D-glucose3beta-galactosyltransferase and UDP-Gal:beta-GlcNAc beta 1,3-galactosyltranferase. Specific galactosyltransferases transfer galactose to GlcNAc terminal chains in the synthesis of the lacto-series oligosaccharides types 1 and 2.","GO:0006486|protein glycosylation;GO:0009312|oligosaccharide biosynthetic process;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0008194|UDP-glycosyltransferase activity;GO:0008499|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity;GO:0016757|transferase activity, transferring glycosyl groups;GO:0047273|galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity;","K00719","B3GALNT1, B3GALT3; galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase [EC:2.4.1.79]"]
["ENSRNOG00000013967",81,5.210765493,509,32.86198656,0.15856514,-2.656852463,{"v":7.30866e-77,"d":"7.31E-77"},{"v":3.43273e-76,"d":"3.43E-76"},"down","yes","Blnk","protein_coding","chr1:239753648-239821113:-","gi|71043856|ref|NP_001020938.1|",2340,0,"B-cell linker protein [Rattus norvegicus]","gi|71043855|ref|NM_001025767.1|",1732,0,"Rattus norvegicus B-cell linker (Blnk), mRNA","Q4KM52",905,0,"B-cell linker protein",".",".",".",".","pfam00017","SH2","SH2 domain.","GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0008150|biological_process;GO:0010628|positive regulation of gene expression;GO:0035556|intracellular signal transduction;GO:0042113|B cell activation;GO:0050853|B cell receptor signaling pathway;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0036464|cytoplasmic ribonucleoprotein granule;","GO:0003674|molecular_function;GO:0019899|enzyme binding;GO:0019901|protein kinase binding;GO:0035591|signaling adaptor activity;GO:0042169|SH2 domain binding;GO:0043274|phospholipase binding;GO:1990782|protein tyrosine kinase binding;","K07371","BLNK; B-cell linker protein"]
["ENSRNOG00000058094",281,18.07685313,898,57.97654997,0.311795944,-1.681325934,{"v":3.60503e-76,"d":"3.61E-76"},{"v":1.68904e-75,"d":"1.69E-75"},"down","yes","AABR07028902.1","protein_coding","chr17:86241384-86443480:+","gi|16758280|ref|NP_445970.1|",19333,0,"lysosomal-trafficking regulator [Rattus norvegicus]","gi|568981579|ref|XM_006516561.1|",9844,0,"PREDICTED: Mus musculus lysosomal trafficking regulator (Lyst), transcript variant X1, mRNA","P97412",7039,0,"Lysosomal-trafficking regulator",".",".",".",".","pfam02138","Beach","Beige/BEACH domain.",".",".",".",".","."]
["ENSRNOG00000018366",7,0.450313067,315,20.33698579,0.022142567,-5.497033716,{"v":4.13248e-76,"d":"4.13E-76"},{"v":1.93142e-75,"d":"1.93E-75"},"down","yes","Cracdl","protein_coding","chr9:39834833-39951086:-","gi|564311478|ref|XP_006226868.1|",5362,0,"PREDICTED: uncharacterized protein KIAA1211-like homolog isoform X3 [Rattus norvegicus]","gi|672023934|ref|XM_006226804.2|",3511,0,"PREDICTED: Rattus norvegicus similar to putative protein (5S487) (RGD1310819), transcript variant X7, mRNA",".",".",".",".",".",".",".",".","pfam15262","DUF4592","Domain of unknown function (DUF4592). This protein family is a domain of unknown function, which lies to the N-terminus of the protein. This domain family is found in eukaryotes, and is typically between 114 and 130 amino acids in length. There are two completely conserved residues (L and A) that may be functionally important. In humans, the gene that encodes this protein lies in the position, chromosome 2 open reading frame 55.",".",".",".",".","."]
["ENSRNOG00000067170",304,19.55645321,935,60.36533878,0.323968251,-1.626075661,{"v":1.25099e-75,"d":"1.25E-75"},{"v":5.83725e-75,"d":"5.84E-75"},"down","yes","ENSRNOG00000067170","lncRNA","chr11:25047618-25056131:+","gi|114145640|ref|NP_001041403.1|",247,{"v":3e-20,"d":"3.00E-20"},"uncharacterized protein LOC499219 [Rattus norvegicus]","gi|672070681|ref|XR_594993.1|",5640,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102552725 (LOC102552725), transcript variant X2, ncRNA",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["ENSRNOG00000019616",12,0.771965258,323,20.85348067,0.037018533,-4.755608473,{"v":1.54082e-75,"d":"1.54E-75"},{"v":7.18374e-75,"d":"7.18E-75"},"down","yes","Prss8","protein_coding","chr1:182536229-182540815:-","gi|20301968|ref|NP_620191.1|",1571,0,"prostasin precursor [Rattus norvegicus]","gi|20301967|ref|NM_138836.1|",1898,0,"Rattus norvegicus protease, serine, 8 (Prss8), mRNA","Q9ES87",607,0,"Prostasin","VC1649",124,{"v":9e-29,"d":"9.00E-29"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0001942|hair follicle development;GO:0006508|proteolysis;GO:0009410|response to xenobiotic stimulus;GO:0010765|positive regulation of sodium ion transport;GO:0043434|response to peptide hormone;GO:0051385|response to mineralocorticoid;GO:0070633|transepithelial transport;GO:1902307|positive regulation of sodium ion transmembrane transport;","GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0019897|extrinsic component of plasma membrane;GO:0045121|membrane raft;GO:0046658|anchored component of plasma membrane;","GO:0004252|serine-type endopeptidase activity;GO:0017080|sodium channel regulator activity;","K08664","PRSS8; prostasin [EC:3.4.21.-]"]
["ENSRNOG00000028036",333,21.42203592,984,63.5288699,0.33720159,-1.568316758,{"v":1.54236E-75,"d":"1.54E-75"},{"v":7.18505e-75,"d":"7.19E-75"},"down","yes","Adamts7","protein_coding","chr8:90704727-90744328:+","gi|114052955|ref|NP_001040566.1|",9229,0,"A disintegrin and metalloproteinase with thrombospondin motifs 7 [Rattus norvegicus]","gi|114052954|ref|NM_001047101.1|",5643,0,"Rattus norvegicus ADAM metallopeptidase with thrombospondin type 1 motif, 7 (Adamts7), mRNA","Q1EHB3",3105,0,"A disintegrin and metalloproteinase with thrombospondin motifs 7",".",".",".",".","pfam05986","ADAM_spacer1","ADAM-TS Spacer 1. This family represents the Spacer-1 region from the ADAM-TS family of metalloproteinases.","GO:0001503|ossification;GO:0002062|chondrocyte differentiation;GO:0006029|proteoglycan metabolic process;GO:0006508|proteolysis;GO:0030198|extracellular matrix organization;GO:0030199|collagen fibril organization;GO:0032331|negative regulation of chondrocyte differentiation;GO:0043931|ossification involved in bone maturation;GO:0051603|proteolysis involved in cellular protein catabolic process;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071773|cellular response to BMP stimulus;","GO:0005576|extracellular region;GO:0009986|cell surface;GO:0031012|extracellular matrix;","GO:0004222|metalloendopeptidase activity;GO:0008237|metallopeptidase activity;GO:0046872|metal ion binding;","K08622","ADAMTS7; a disintegrin and metalloproteinase with thrombospondin motifs 7 [EC:3.4.24.-]"]
["ENSRNOG00000004026",981,63.10815986,1964,126.7994924,0.497700414,-1.006650507,{"v":1.80423e-75,"d":"1.80E-75"},{"v":8.39131e-75,"d":"8.39E-75"},"down","yes","Atp2b1","protein_coding","chr7:33735871-33843295:+","gi|564359109|ref|XP_006241356.1|",6120,0,"PREDICTED: plasma membrane calcium-transporting ATPase 1 isoform X1 [Rattus norvegicus]","gi|672058567|ref|XM_006241294.2|",5319,0,"PREDICTED: Rattus norvegicus ATPase, Ca++ transporting, plasma membrane 1 (Atp2b1), transcript variant X1, mRNA","P11505",2326,0,"Plasma membrane calcium-transporting ATPase 1",".",".",".",".","pfam00689","Cation_ATPase_C","Cation transporting ATPase, C-terminus. Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.","GO:0001818|negative regulation of cytokine production;GO:0003056|regulation of vascular smooth muscle contraction;GO:0003407|neural retina development;GO:0006874|cellular calcium ion homeostasis;GO:0007420|brain development;GO:0007568|aging;GO:0008217|regulation of blood pressure;GO:0009409|response to cold;GO:0030501|positive regulation of bone mineralization;GO:0051480|regulation of cytosolic calcium ion concentration;GO:0051481|negative regulation of cytosolic calcium ion concentration;GO:0051928|positive regulation of calcium ion transport;GO:0071305|cellular response to vitamin D;GO:0071386|cellular response to corticosterone stimulus;GO:0099509|regulation of presynaptic cytosolic calcium ion concentration;GO:1900076|regulation of cellular response to insulin stimulus;GO:1901660|calcium ion export;GO:1990034|calcium ion export across plasma membrane;","GO:0001772|immunological synapse;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009898|cytoplasmic side of plasma membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0030285|integral component of synaptic vesicle membrane;GO:0032590|dendrite membrane;GO:0032591|dendritic spine membrane;GO:0032809|neuronal cell body membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0045121|membrane raft;GO:0045177|apical part of cell;GO:0098978|glutamatergic synapse;GO:0098982|GABA-ergic synapse;GO:0099056|integral component of presynaptic membrane;GO:0099059|integral component of presynaptic active zone membrane;","GO:0005388|calcium-transporting ATPase activity;GO:0005516|calmodulin binding;GO:0005524|ATP binding;GO:0015085|calcium ion transmembrane transporter activity;GO:0019829|cation-transporting ATPase activity;GO:0030165|PDZ domain binding;GO:0046872|metal ion binding;GO:1905056|calcium-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration;","K05850","ATP2B; P-type Ca2+ transporter type 2B [EC:7.2.2.10]"]
["ENSRNOG00000059406",277,17.81953138,887,57.26636951,0.311169217,-1.684228748,{"v":1.93836E-75,"d":"1.94E-75"},{"v":9.00779e-75,"d":"9.01E-75"},"down","yes","Ier5","protein_coding","chr13:67270135-67272227:-","gi|60551405|gb|AAH91181.1|",313,{"v":2e-31,"d":"2.00E-31"},"Ier5 protein [Rattus norvegicus]","gi|60551404|gb|BC091181.1|",1368,0,"Rattus norvegicus immediate early response 5, mRNA (cDNA clone IMAGE:7326120), complete cds","O89113",122,{"v":8e-30,"d":"8.00E-30"},"Immediate early response gene 5 protein",".",".",".",".","pfam05760","IER","Immediate early response protein (IER). This family consists of several eukaryotic immediate early response (IER) 2 and 5 proteins. The role of IER5 is unclear although it play an important role in mediating the cellular response to mitogenic signals. Again, little is known about the function of IER2 although it is thought to play a role in mediating the cellular responses to a variety of extracellular signals.","GO:0034605|cellular response to heat;GO:0042127|regulation of cell proliferation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:1900036|positive regulation of cellular response to heat;","GO:0000159|protein phosphatase type 2A complex;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;","GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000010897",317,20.3927489,955,61.65657597,0.330747347,-1.596198512,{"v":3.21247e-75,"d":"3.21E-75"},{"v":1.48924E-74,"d":"1.49E-74"},"down","yes","Nek6","protein_coding","chr3:22284279-22395990:+","gi|33636728|ref|NP_891998.1|",1701,0,"serine/threonine-protein kinase Nek6 [Rattus norvegicus]","gi|469663647|ref|NM_182953.2|",2286,0,"Rattus norvegicus NIMA-related kinase 6 (Nek6), transcript variant 1, mRNA","P59895",659,0,"Serine/threonine-protein kinase Nek6",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006468|protein phosphorylation;GO:0006915|apoptotic process;GO:0007059|chromosome segregation;GO:0018105|peptidyl-serine phosphorylation;GO:0030071|regulation of mitotic metaphase/anaphase transition;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0046777|protein autophosphorylation;GO:0051301|cell division;","GO:0000922|spindle pole;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0005829|cytosol;GO:0016607|nuclear speck;GO:0032991|protein-containing complex;GO:0034451|centriolar satellite;","GO:0000287|magnesium ion binding;GO:0001222|transcription corepressor binding;GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;GO:0019894|kinesin binding;GO:0019901|protein kinase binding;GO:0031625|ubiquitin protein ligase binding;","K20875","NEK6; NIMA (never in mitosis gene a)-related kinase 6 [EC:2.7.11.1]"]
["ENSRNOG00000007905",48,3.087861033,419,27.0514192,0.114147839,-3.131024552,{"v":1.30316E-74,"d":"1.30E-74"},{"v":6.01676e-74,"d":"6.02E-74"},"down","yes","Itga7","protein_coding","chr7:1359940-1388450:+","gi|564357861|ref|XP_006240862.1|",5355,0,"PREDICTED: integrin alpha-7 isoform X1 [Rattus norvegicus]","gi|57528940|ref|NM_030842.1|",2731,0,"Rattus norvegicus integrin subunit alpha 7 (Itga7), mRNA","Q63258",2018,0,"Integrin alpha-7",".",".",".",".","pfam08441","Integrin_alpha2","Integrin alpha. This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.","GO:0007155|cell adhesion;GO:0007229|integrin-mediated signaling pathway;GO:0007519|skeletal muscle tissue development;GO:0008360|regulation of cell shape;GO:0016477|cell migration;GO:0034113|heterotypic cell-cell adhesion;GO:0035987|endodermal cell differentiation;GO:0048514|blood vessel morphogenesis;","GO:0005737|cytoplasm;GO:0005927|muscle tendon junction;GO:0008305|integrin complex;GO:0009986|cell surface;GO:0031594|neuromuscular junction;GO:0034677|integrin alpha7-beta1 complex;GO:0042383|sarcolemma;","GO:0005178|integrin binding;GO:0005515|protein binding;GO:0043236|laminin binding;GO:0044877|protein-containing complex binding;GO:0046872|metal ion binding;GO:0050839|cell adhesion molecule binding;","K06583","ITGA7; integrin alpha 7"]
["ENSRNOG00000009343",52,3.345182786,428,27.63247593,0.121059828,-3.046207888,{"v":2.6637e-74,"d":"2.66E-74"},{"v":1.22786E-73,"d":"1.23E-73"},"down","yes","Evpl","protein_coding","chr10:101458216-101474763:-","gi|157818855|ref|NP_001100536.1|",9073,0,"envoplakin [Rattus norvegicus]","gi|157818854|ref|NM_001107066.1|",6090,0,"Rattus norvegicus envoplakin (Evpl), mRNA","Q9D952",3257,0,"Envoplakin",".",".",".",".","pfam00681","Plectin","Plectin repeat. This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.","GO:0018149|peptide cross-linking;GO:0030216|keratinocyte differentiation;GO:0042060|wound healing;GO:0045104|intermediate filament cytoskeleton organization;","GO:0001533|cornified envelope;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005882|intermediate filament;GO:0016020|membrane;GO:0045111|intermediate filament cytoskeleton;","GO:0005198|structural molecule activity;GO:0019215|intermediate filament binding;","K10383","EVPL; envoplakin"]
["ENSRNOG00000012721",473,30.42829726,1204,77.73247902,0.39144895,-1.353103923,{"v":3.64789e-74,"d":"3.65E-74"},{"v":1.67882e-73,"d":"1.68E-73"},"down","yes","Ednra","protein_coding","chr19:30233571-30297049:+","gi|7549758|ref|NP_036682.1|",2113,0,"endothelin-1 receptor precursor [Rattus norvegicus]","gi|672084725|ref|XM_006255420.2|",3885,0,"PREDICTED: Rattus norvegicus endothelin receptor type A (Ednra), transcript variant X2, mRNA","P26684",814,0,"Endothelin-1 receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0000278|mitotic cell cycle;GO:0001525|angiogenesis;GO:0001569|branching involved in blood vessel morphogenesis;GO:0001666|response to hypoxia;GO:0001701|in utero embryonic development;GO:0001821|histamine secretion;GO:0001934|positive regulation of protein phosphorylation;GO:0001974|blood vessel remodeling;GO:0001975|response to amphetamine;GO:0002027|regulation of heart rate;GO:0003094|glomerular filtration;GO:0003207|cardiac chamber formation;GO:0003220|left ventricular cardiac muscle tissue morphogenesis;GO:0003228|atrial cardiac muscle tissue development;GO:0003253|cardiac neural crest cell migration involved in outflow tract morphogenesis;GO:0003357|noradrenergic neuron differentiation;GO:0006468|protein phosphorylation;GO:0006874|cellular calcium ion homeostasis;GO:0007005|mitochondrion organization;GO:0007193|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007205|protein kinase C-activating G protein-coupled receptor signaling pathway;GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0007266|Rho protein signal transduction;GO:0007382|specification of segmental identity, maxillary segment;GO:0007411|axon guidance;GO:0007507|heart development;GO:0007568|aging;GO:0007585|respiratory gaseous exchange;GO:0008217|regulation of blood pressure;GO:0008284|positive regulation of cell proliferation;GO:0009611|response to wounding;GO:0010033|response to organic substance;GO:0010259|multicellular organism aging;GO:0010467|gene expression;GO:0010827|regulation of glucose transmembrane transport;GO:0014032|neural crest cell development;GO:0014033|neural crest cell differentiation;GO:0014034|neural crest cell fate commitment;GO:0014070|response to organic cyclic compound;GO:0014824|artery smooth muscle contraction;GO:0016322|neuron remodeling;GO:0019233|sensory perception of pain;GO:0030202|heparin metabolic process;GO:0030878|thyroid gland development;GO:0031175|neuron projection development;GO:0032496|response to lipopolysaccharide;GO:0032835|glomerulus development;GO:0034599|cellular response to oxidative stress;GO:0035050|embryonic heart tube development;GO:0035904|aorta development;GO:0042305|specification of segmental identity, mandibular segment;GO:0042310|vasoconstriction;GO:0042415|norepinephrine metabolic process;GO:0042474|middle ear morphogenesis;GO:0042482|positive regulation of odontogenesis;GO:0043066|negative regulation of apoptotic process;GO:0043084|penile erection;GO:0043278|response to morphine;GO:0044751|cellular response to human chorionic gonadotropin stimulus;GO:0048144|fibroblast proliferation;GO:0048484|enteric nervous system development;GO:0048485|sympathetic nervous system development;GO:0048659|smooth muscle cell proliferation;GO:0048675|axon extension;GO:0048706|embryonic skeletal system development;GO:0050678|regulation of epithelial cell proliferation;GO:0050729|positive regulation of inflammatory response;GO:0050905|neuromuscular process;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;GO:0051482|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway;GO:0051928|positive regulation of calcium ion transport;GO:0055078|sodium ion homeostasis;GO:0060070|canonical Wnt signaling pathway;GO:0060137|maternal process involved in parturition;GO:0060322|head development;GO:0060324|face development;GO:0060385|axonogenesis involved in innervation;GO:0061028|establishment of endothelial barrier;GO:0061626|pharyngeal arch artery morphogenesis;GO:0070294|renal sodium ion absorption;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070588|calcium ion transmembrane transport;GO:0071260|cellular response to mechanical stimulus;GO:0071310|cellular response to organic substance;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0071373|cellular response to luteinizing hormone stimulus;GO:0071806|protein transmembrane transport;GO:0072011|glomerular endothelium development;GO:0072112|glomerular visceral epithelial cell differentiation;GO:0086100|endothelin receptor signaling pathway;GO:0086101|endothelin receptor signaling pathway involved in heart process;GO:0090023|positive regulation of neutrophil chemotaxis;GO:0090184|positive regulation of kidney development;GO:0097018|renal albumin absorption;GO:0097084|vascular smooth muscle cell development;GO:0097152|mesenchymal cell apoptotic process;GO:0097492|sympathetic neuron axon guidance;GO:1902287|semaphorin-plexin signaling pathway involved in axon guidance;GO:1903210|glomerular visceral epithelial cell apoptotic process;GO:1903537|meiotic cell cycle process involved in oocyte maturation;GO:1904888|cranial skeletal system development;GO:1905144|response to acetylcholine;GO:1905871|regulation of protein localization to cell leading edge;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030315|T-tubule;GO:0031965|nuclear membrane;GO:0045121|membrane raft;GO:0071944|cell periphery;","GO:0004962|endothelin receptor activity;","K04197","EDNRA; endothelin receptor type A"]
["ENSRNOG00000031743",741,47.66885469,1610,103.944594,0.45859869,-1.12469586,{"v":3.65409e-74,"d":"3.65E-74"},{"v":1.68033e-73,"d":"1.68E-73"},"down","yes","Gbp2","protein_coding","chr2:231332284-231348571:+","gi|19424350|ref|NP_598308.1|",3150,0,"guanylate-binding protein 1 [Rattus norvegicus]","gi|402691659|ref|NM_133624.2|",2390,0,"Rattus norvegicus guanylate binding protein 2 (Gbp2), mRNA","Q63663",1212,0,"Guanylate-binding protein 1",".",".",".",".","pfam02841","GBP_C","Guanylate-binding protein, C-terminal domain. Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.","GO:0009617|response to bacterium;GO:0034504|protein localization to nucleus;GO:0035458|cellular response to interferon-beta;GO:0042832|defense response to protozoan;GO:0044406|adhesion of symbiont to host;GO:0050830|defense response to Gram-positive bacterium;GO:0071222|cellular response to lipopolysaccharide;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;","GO:0000139|Golgi membrane;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0031410|cytoplasmic vesicle;GO:0048471|perinuclear region of cytoplasm;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;","K20897","GBP2; guanylate-binding protein 2"]
["ENSRNOG00000055716",37,2.380226213,388,25.05000155,0.095019005,-3.395640096,{"v":3.73827e-74,"d":"3.74E-74"},{"v":1.71765e-73,"d":"1.72E-73"},"down","yes","Oscar","protein_coding","chr1:65607410-65613758:+","gi|564325642|ref|XP_006228082.1|",1273,{"v":1e-157,"d":"1.00E-157"},"PREDICTED: osteoclast-associated immunoglobulin-like receptor isoform X1 [Rattus norvegicus]","gi|34368610|gb|AC103574.7|",4382,0,"Rattus norvegicus 1 BAC CH230-205C19 (Children's Hospital Oakland Research Institute) complete sequence","Q8VBT3",417,{"v":3E-131,"d":"3.00E-131"},"Osteoclast-associated immunoglobulin-like receptor",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0030316|osteoclast differentiation;GO:0038065|collagen-activated signaling pathway;GO:0038094|Fc-gamma receptor signaling pathway;GO:0045780|positive regulation of bone resorption;GO:0072674|multinuclear osteoclast differentiation;","GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0038064|collagen receptor activity;","K14377","OSCAR; osteoclast-associated immunoglobulin-like receptor"]
["ENSRNOG00000018262",136,8.748939593,614,39.64098183,0.220704412,-2.179812623,{"v":1.03419E-73,"d":"1.03E-73"},{"v":4.72903e-73,"d":"4.73E-73"},"down","yes","Ampd3","protein_coding","chr1:164885320-164929887:+","gi|564330385|ref|XP_006230072.1|",4208,0,"PREDICTED: AMP deaminase 3 isoform X1 [Rattus norvegicus]","gi|672037700|ref|XM_006230010.2|",4127,0,"PREDICTED: Rattus norvegicus adenosine monophosphate deaminase 3 (Ampd3), transcript variant X1, mRNA","O09178",1564,0,"AMP deaminase 3","YML035c",574,0,"COG1816","pfam00962","A_deaminase","Adenosine/AMP deaminase.","GO:0006188|IMP biosynthetic process;GO:0006196|AMP catabolic process;GO:0032264|IMP salvage;GO:0034101|erythrocyte homeostasis;GO:0046031|ADP metabolic process;GO:0046032|ADP catabolic process;GO:0046033|AMP metabolic process;GO:0046034|ATP metabolic process;GO:0046039|GTP metabolic process;GO:0097009|energy homeostasis;","GO:0005829|cytosol;","GO:0003876|AMP deaminase activity;GO:0046872|metal ion binding;","K01490","AMPD; AMP deaminase [EC:3.5.4.6]"]
["ENSRNOG00000058645",516,33.1945061,1268,81.86443804,0.40548139,-1.302292394,{"v":1.19333E-73,"d":"1.19E-73"},{"v":5.44801e-73,"d":"5.45E-73"},"down","yes","Tnc","protein_coding","chr5:77375851-77460624:-","gi|672052772|ref|XP_008761976.1|",11592,0,"PREDICTED: tenascin isoform X2 [Rattus norvegicus]","gi|672052771|ref|XM_008763754.1|",7527,0,"PREDICTED: Rattus norvegicus tenascin C (Tnc), transcript variant X1, mRNA","P24821",3703,0,"Tenascin",".",".",".",".","pfam00147","Fibrinogen_C","Fibrinogen beta and gamma chains, C-terminal globular domain.","GO:0007155|cell adhesion;GO:0007162|negative regulation of cell adhesion;GO:0007528|neuromuscular junction development;GO:0008284|positive regulation of cell proliferation;GO:0009611|response to wounding;GO:0009612|response to mechanical stimulus;GO:0010628|positive regulation of gene expression;GO:0014012|peripheral nervous system axon regeneration;GO:0031175|neuron projection development;GO:0042060|wound healing;GO:0042475|odontogenesis of dentin-containing tooth;GO:0045471|response to ethanol;GO:0060447|bud outgrowth involved in lung branching;GO:0060739|mesenchymal-epithelial cell signaling involved in prostate gland development;GO:0060740|prostate gland epithelium morphogenesis;GO:0071300|cellular response to retinoic acid;GO:0071305|cellular response to vitamin D;GO:0071774|response to fibroblast growth factor;GO:0071799|cellular response to prostaglandin D stimulus;","GO:0005576|extracellular region;GO:0005604|basement membrane;GO:0005614|interstitial matrix;GO:0031012|extracellular matrix;GO:0098966|perisynaptic extracellular matrix;","GO:0003674|molecular_function;GO:0045545|syndecan binding;","K06252","TN; tenascin"]
["ENSRNOG00000068415",0,0.032165219,421,27.18054291,1.183391E-3,-9.722857042,{"v":1.24428e-73,"d":"1.24E-73"},{"v":5.67607e-73,"d":"5.68E-73"},"down","yes","Lrrc15","protein_coding","chr11:70469804-70484267:+","gi|564377191|ref|XP_006248544.1|",2584,0,"PREDICTED: leucine-rich repeat-containing protein 15 isoform X1 [Rattus norvegicus]","gi|672071373|ref|XM_006248482.2|",2068,0,"PREDICTED: Rattus norvegicus leucine rich repeat containing 15 (Lrrc15), transcript variant X1, mRNA","Q8R5M3",994,0,"Leucine-rich repeat-containing protein 15","alr0124_1",88.6,{"v":4e-17,"d":"4.00E-17"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.",".",".",".",".","."]
["ENSRNOG00000062276",143,9.19925266,627,40.480286,0.22725266,-2.137630915,{"v":1.84645e-73,"d":"1.85E-73"},{"v":8.40289e-73,"d":"8.40E-73"},"down","yes","AABR07044631.2","protein_coding","chr20:13043257-13071450:-","gi|56799404|ref|NP_062108.2|",2779,0,"gamma-glutamyltransferase 5 [Rattus norvegicus]","gi|56799403|ref|NM_019235.2|",2592,0,"Rattus norvegicus gamma-glutamyltransferase 5 (Ggt5), mRNA","Q9QWE9",1071,0,"Glutathione hydrolase 5 proenzyme","SPAC664.09",231,{"v":2e-64,"d":"2.00E-64"},"COG0405","pfam01019","G_glu_transpept","Gamma-glutamyltranspeptidase.",".",".",".",".","."]
["ENSRNOG00000019604",546,35.12441925,1312,84.70515987,0.41466682,-1.269975483,{"v":2.69567e-73,"d":"2.70E-73"},{"v":1.22481e-72,"d":"1.22E-72"},"down","yes","Pld2","protein_coding","chr10:55256359-55272808:+","gi|31377516|ref|NP_150641.2|",4985,0,"phospholipase D2 [Rattus norvegicus]","gi|699045643|ref|NM_001302475.1|",2595,0,"Mus musculus phospholipase D2 (Pld2), transcript variant 1, mRNA","P70498",1875,0,"Phospholipase D2","SPAC2F7.16c",415,{"v":2e-123,"d":"2.00E-123"},"COG1502","pfam00787","PX","PX domain. PX domains bind to phosphoinositides.","GO:0001666|response to hypoxia;GO:0002031|G protein-coupled receptor internalization;GO:0006654|phosphatidic acid biosynthetic process;GO:0006898|receptor-mediated endocytosis;GO:0009395|phospholipid catabolic process;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0014070|response to organic cyclic compound;GO:0016042|lipid catabolic process;GO:0030335|positive regulation of cell migration;GO:0031175|neuron projection development;GO:0042542|response to hydrogen peroxide;GO:0043306|positive regulation of mast cell degranulation;GO:0043434|response to peptide hormone;GO:0045785|positive regulation of cell adhesion;GO:0048017|inositol lipid-mediated signaling;GO:0048260|positive regulation of receptor-mediated endocytosis;GO:0048870|cell motility;","GO:0005634|nucleus;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005901|caveola;GO:0030027|lamellipodium;GO:0031526|brush border membrane;GO:0042383|sarcolemma;","GO:0004630|phospholipase D activity;GO:0005080|protein kinase C binding;GO:0005515|protein binding;GO:0035091|phosphatidylinositol binding;GO:0070290|N-acylphosphatidylethanolamine-specific phospholipase D activity;","K01115","PLD1_2; phospholipase D1/2 [EC:3.1.4.4]"]
["ENSRNOG00000058906",17,1.093617449,328,21.17628997,0.051643487,-4.275269783,{"v":2.78604e-73,"d":"2.79E-73"},{"v":1.26486E-72,"d":"1.26E-72"},"down","yes","Ptprh","protein_coding","chr1:69242321-69285077:+","gi|300794452|ref|NP_001178874.1|",4371,0,"receptor-type tyrosine-protein phosphatase H precursor [Rattus norvegicus]","gi|672034916|ref|XM_008758887.1|",2272,0,"PREDICTED: Rattus norvegicus protein tyrosine phosphatase, receptor type, H (Ptprh), transcript variant X1, mRNA","E9Q0N2",1371,0,"Receptor-type tyrosine-protein phosphatase H","SPAC11E3.09",129,{"v":7e-31,"d":"7.00E-31"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:1990264|peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity;","GO:0005902|microvillus;GO:0016021|integral component of membrane;","GO:0005001|transmembrane receptor protein tyrosine phosphatase activity;GO:0045296|cadherin binding;","K18034","PTPRH, SAP1; receptor-type tyrosine-protein phosphatase H [EC:3.1.3.48]"]
["ENSRNOG00000055721",39,2.508887089,389,25.11456341,0.099897699,-3.323404745,{"v":4.7538E-73,"d":"4.75E-73"},{"v":2.15138e-72,"d":"2.15E-72"},"down","yes","ENSRNOG00000055721","protein_coding","chrX:103183831-103298423:+","gi|148691965|gb|EDL23912.1|",2446,0,"ring finger protein 128, partial [Mus musculus]","gi|298915108|emb|FQ210020.1|",2708,0,"Rattus norvegicus TL0ABA36YD02 mRNA sequence","Q9D304",849,0,"E3 ubiquitin-protein ligase RNF128",".",".",".",".","pfam13639","zf-RING_2","Ring finger domain.","GO:0001818|negative regulation of cytokine production;GO:0006511|ubiquitin-dependent protein catabolic process;GO:0016567|protein ubiquitination;GO:0031647|regulation of protein stability;","GO:0005737|cytoplasm;GO:0005770|late endosome;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;","GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;","K10629","RNF128, GRAIL; E3 ubiquitin-protein ligase RNF128 [EC:2.3.2.27]"]
["ENSRNOG00000008376",220,14.1526964,772,49.84175565,0.283952606,-1.816277943,{"v":5.28522e-73,"d":"5.29E-73"},{"v":2.3881E-72,"d":"2.39E-72"},"down","yes","Slc2a3","protein_coding","chr4:155960946-156025472:-","gi|148747140|ref|NP_058798.2|",2341,0,"solute carrier family 2, facilitated glucose transporter member 3 [Rattus norvegicus]","gi|672050993|ref|XM_003749833.3|",1993,0,"PREDICTED: Rattus norvegicus solute carrier family 2, facilitated glucose transporter member 3-like (LOC100909595), mRNA","Q07647",903,0,"Solute carrier family 2, facilitated glucose transporter member 3",".",".",".",".","pfam00083","Sugar_tr","Sugar (and other) transporter.","GO:0009749|response to glucose;GO:0015749|monosaccharide transmembrane transport;GO:0021987|cerebral cortex development;GO:0043066|negative regulation of apoptotic process;GO:0046323|glucose import;GO:0070837|dehydroascorbic acid transport;GO:0098708|glucose import across plasma membrane;GO:1904016|response to Thyroglobulin triiodothyronine;GO:1904659|glucose transmembrane transport;","GO:0002080|acrosomal membrane;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005901|caveola;GO:0016021|integral component of membrane;GO:0030672|synaptic vesicle membrane;GO:0042995|cell projection;GO:0043204|perikaryon;GO:0098978|glutamatergic synapse;GO:0099699|integral component of synaptic membrane;","GO:0005355|glucose transmembrane transporter activity;GO:0005515|protein binding;GO:0005536|glucose binding;GO:0015145|monosaccharide transmembrane transporter activity;GO:0016936|galactoside binding;GO:0019900|kinase binding;GO:0033222|xylose binding;GO:0033300|dehydroascorbic acid transmembrane transporter activity;GO:0055056|D-glucose transmembrane transporter activity;","K08142","SLC2A3, GLUT3; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 3"]
["ENSRNOG00000065398",129,8.298626526,596,38.47886835,0.215667115,-2.213121884,{"v":6.2853e-73,"d":"6.29E-73"},{"v":2.83549e-72,"d":"2.84E-72"},"down","yes","ENSRNOG00000065398","lncRNA","chr17:4481915-4486028:-","gi|109505396|ref|XP_001066058.1|",970,{"v":9e-116,"d":"9.00E-116"},"PREDICTED: growth arrest-specific protein 1 [Rattus norvegicus]","gi|29501932|gb|AC122402.2|",2515,0,"Mus musculus BAC clone RP24-108B4 from chromosome 13, complete sequence","Q01721",344,{"v":1e-105,"d":"1.00E-105"},"Growth arrest-specific protein 1",".",".",".",".","pfam02351","GDNF","GDNF/GAS1 domain. This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.",".",".",".",".","."]
["ENSRNOG00000002792",48,3.087861033,411,26.53492432,0.116369694,-3.103212702,{"v":1.22182E-72,"d":"1.22E-72"},{"v":5.48599e-72,"d":"5.49E-72"},"down","yes","Cxcl2","protein_coding","chr14:17181062-17183075:-","gi|16758460|ref|NP_446099.1|",440,{"v":2E-50,"d":"2.00E-50"},"C-X-C motif chemokine 2 precursor [Rattus norvegicus]","gi|16758459|ref|NM_053647.1|",1041,0,"Rattus norvegicus chemokine (C-X-C motif) ligand 2 (Cxcl2), mRNA","P30348",174,{"v":6E-52,"d":"6.00E-52"},"C-X-C motif chemokine 2",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0001975|response to amphetamine;GO:0002237|response to molecule of bacterial origin;GO:0006954|inflammatory response;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0009408|response to heat;GO:0010332|response to gamma radiation;GO:0030593|neutrophil chemotaxis;GO:0030595|leukocyte chemotaxis;GO:0031640|killing of cells of other organism;GO:0032355|response to estradiol;GO:0042060|wound healing;GO:0051384|response to glucocorticoid;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098|chemokine-mediated signaling pathway;GO:0070997|neuron death;GO:0071222|cellular response to lipopolysaccharide;GO:0071347|cellular response to interleukin-1;","GO:0005615|extracellular space;","GO:0008009|chemokine activity;GO:0045236|CXCR chemokine receptor binding;","K05505","CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3"]
["ENSRNOG00000017869",316,20.32841847,938,60.55902436,0.335679425,-1.574843984,{"v":1.60843E-72,"d":"1.61E-72"},{"v":7.21622e-72,"d":"7.22E-72"},"down","yes","Irf8","protein_coding","chr19:48790588-48811829:+","gi|56790291|ref|NP_001008722.1|",2280,0,"interferon regulatory factor 8 [Rattus norvegicus]","gi|672085188|ref|XM_006255737.2|",2278,0,"PREDICTED: Rattus norvegicus interferon regulatory factor 8 (Irf8), transcript variant X1, mRNA","P23611",849,0,"Interferon regulatory factor 8",".",".",".",".","pfam10401","IRF-3","Interferon-regulatory factor 3. This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1).  Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0002273|plasmacytoid dendritic cell differentiation;GO:0002314|germinal center B cell differentiation;GO:0002316|follicular B cell differentiation;GO:0002376|immune system process;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006909|phagocytosis;GO:0006955|immune response;GO:0009617|response to bacterium;GO:0030099|myeloid cell differentiation;GO:0032479|regulation of type I interferon production;GO:0032729|positive regulation of interferon-gamma production;GO:0032735|positive regulation of interleukin-12 production;GO:0042742|defense response to bacterium;GO:0042832|defense response to protozoan;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0060261|positive regulation of transcription initiation from RNA polymerase II promoter;GO:0071222|cellular response to lipopolysaccharide;GO:0071346|cellular response to interferon-gamma;GO:0097028|dendritic cell differentiation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0005515|protein binding;GO:1990837|sequence-specific double-stranded DNA binding;","K10155","IRF8; interferon regulatory factor 8"]
["ENSRNOG00000021242",528,33.96647136,1277,82.44549478,0.411986992,-1.27932931,{"v":3.44135E-72,"d":"3.44E-72"},{"v":1.53913E-71,"d":"1.54E-71"},"down","yes","Adam33","protein_coding","chr3:118271029-118283461:-","gi|672017447|ref|XP_008773761.1|",3870,0,"PREDICTED: disintegrin and metalloproteinase domain-containing protein 33 [Rattus norvegicus]","gi|672017446|ref|XM_008775539.1|",3160,0,"PREDICTED: Rattus norvegicus ADAM metallopeptidase domain 33 (Adam33), mRNA","Q923W9",1267,0,"Disintegrin and metalloproteinase domain-containing protein 33",".",".",".",".","pfam01421","Reprolysin","Reprolysin (M12B) family zinc metalloprotease. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as human ADAM8 and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.","GO:0006508|proteolysis;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0004222|metalloendopeptidase activity;","K08616","ADAM33; disintegrin and metalloproteinase domain-containing protein 33 [EC:3.4.24.-]"]
["ENSRNOG00000014768",89,5.725408998,506,32.66830099,0.175258854,-2.512440763,{"v":5.86501e-72,"d":"5.87E-72"},{"v":2.61899e-71,"d":"2.62E-71"},"down","yes","Glis3","protein_coding","chr1:225976326-226395899:-","gi|113866026|ref|NP_780668.3|",3834,0,"zinc finger protein GLIS3 isoform 1 [Mus musculus]","gi|672014756|ref|XM_008774786.1|",4432,0,"PREDICTED: Rattus norvegicus GLIS family zinc finger 3 (Glis3), transcript variant X1, mRNA","Q6XP49",1228,0,"Zinc finger protein GLIS3",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.",".",".",".",".","."]
["ENSRNOG00000007078",19,1.222278326,328,21.17628997,0.057719191,-4.114805111,{"v":8.35557e-72,"d":"8.36E-72"},{"v":3.72822e-71,"d":"3.73E-71"},"down","yes","Ccn4","protein_coding","chr7:98645182-98677248:+","gi|50926796|gb|AAH78787.1|",1525,0,"Wisp1 protein [Rattus norvegicus]","gi|166706547|gb|AC120745.5|",2049,0,"Rattus norvegicus BAC CH230-25E14 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q99PP0",515,{"v":3e-167,"d":"3.00E-167"},"WNT1-inducible-signaling pathway protein 1",".",".",".",".","pfam00219","IGFBP","Insulin-like growth factor binding protein.","GO:0001649|osteoblast differentiation;GO:0001817|regulation of cytokine production;GO:0007155|cell adhesion;GO:0007165|signal transduction;GO:0014911|positive regulation of smooth muscle cell migration;GO:0016055|Wnt signaling pathway;GO:0030177|positive regulation of Wnt signaling pathway;GO:0030316|osteoclast differentiation;GO:0032331|negative regulation of chondrocyte differentiation;GO:0042593|glucose homeostasis;GO:0045599|negative regulation of fat cell differentiation;GO:0045669|positive regulation of osteoblast differentiation;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0050729|positive regulation of inflammatory response;GO:0060348|bone development;GO:0060548|negative regulation of cell death;GO:0061051|positive regulation of cell growth involved in cardiac muscle cell development;GO:0090303|positive regulation of wound healing;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0031012|extracellular matrix;","GO:0003674|molecular_function;GO:0005178|integrin binding;GO:0005520|insulin-like growth factor binding;GO:0008201|heparin binding;","K22471","CCN4, WISP1; CCN family member 4"]
["ENSRNOG00000070985",208,13.38073114,743,47.96946172,0.278942699,-1.841959302,{"v":1.17369E-71,"d":"1.17E-71"},{"v":5.22879e-71,"d":"5.23E-71"},"down","yes","ENSRNOG00000070985","lncRNA","chr4:162636187-162675008:-",".",".",".",".","gi|672018801|ref|XR_600854.1|",3643,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103692233 (LOC103692233), ncRNA",".",".",".",".",".",".",".",".","pfam00112","Peptidase_C1","Papain family cysteine protease.",".",".",".",".","."]
["ENSRNOG00000016932",275,17.6908705,862,55.65232302,0.317881978,-1.65343687,{"v":1.62991e-71,"d":"1.63E-71"},{"v":7.24992e-71,"d":"7.25E-71"},"down","yes","Simc1","protein_coding","chr17:10061757-10106910:-","gi|564390609|ref|XP_006253726.1|",5259,0,"PREDICTED: SUMO-interacting motif-containing protein 1 isoform X1 [Rattus norvegicus]","gi|672081210|ref|XM_006253664.2|",4571,0,"PREDICTED: Rattus norvegicus SUMO-interacting motifs containing 1 (Simc1), transcript variant X1, mRNA","Q8NDZ2",828,0,"SUMO-interacting motif-containing protein 1",".",".",".",".","pfam09606","Med15","ARC105 or Med15 subunit of Mediator complex non-fungal. The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.","GO:0010466|negative regulation of peptidase activity;","GO:0005737|cytoplasm;GO:0030017|sarcomere;","GO:0030414|peptidase inhibitor activity;GO:0032184|SUMO polymer binding;",".","."]
["ENSRNOG00000023643",64,4.117148044,446,28.79458941,0.142983391,-2.806080519,{"v":1.78515E-71,"d":"1.79E-71"},{"v":7.93429e-71,"d":"7.93E-71"},"down","yes","Mmp17","protein_coding","chr12:27074409-27099316:-","gi|157786912|ref|NP_001099395.1|",2729,0,"matrix metalloproteinase-17 precursor [Rattus norvegicus]","gi|157786911|ref|NM_001105925.1|",3509,0,"Rattus norvegicus matrix metallopeptidase 17 (Mmp17), mRNA","Q9R0S3",1017,0,"Matrix metalloproteinase-17",".",".",".",".","pfam00413","Peptidase_M10","Matrixin. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.","GO:0001822|kidney development;GO:0006508|proteolysis;GO:0030198|extracellular matrix organization;GO:0030574|collagen catabolic process;GO:0042756|drinking behavior;","GO:0031012|extracellular matrix;","GO:0004222|metalloendopeptidase activity;GO:0008270|zinc ion binding;","K07997","MMP17; matrix metalloproteinase-17 (membrane-inserted) [EC:3.4.24.-]"]
["ENSRNOG00000066773",285,18.33417488,879,56.74987464,0.323069875,-1.630081865,{"v":1.86096e-71,"d":"1.86E-71"},{"v":8.26478e-71,"d":"8.26E-71"},"down","yes","RT1-DMa","protein_coding","chr20:4707028-4710432:-","gi|38454220|ref|NP_942036.1|",1099,{"v":1e-145,"d":"1.00E-145"},"RT1 class II, DM alpha precursor [Rattus norvegicus]","gi|672085841|ref|XM_006256035.2|",693,0,"PREDICTED: Rattus norvegicus class II histocompatibility antigen, M alpha chain-like (LOC100909593), mRNA","P28078",377,{"v":4e-127,"d":"4.00E-127"},"Class II histocompatibility antigen, M alpha chain",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.",".",".",".",".","."]
["ENSRNOG00000018915",13,0.836295696,308,19.88505277,0.042056499,-4.571527442,{"v":4.6317E-71,"d":"4.63E-71"},{"v":2.04745e-70,"d":"2.05E-70"},"down","yes","Tagap","protein_coding","chr1:47170725-47179792:-","gi|827342578|ref|NP_001296378.1|",3627,0,"T-cell activation Rho GTPase-activating protein [Rattus norvegicus]","gi|672012747|ref|XM_003753172.3|",3184,0,"PREDICTED: Rattus norvegicus T-cell activation RhoGTPase activating protein (Tagap), transcript variant X1, mRNA","B2RWW0",1198,0,"T-cell activation Rho GTPase-activating protein",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0007165|signal transduction;GO:0050790|regulation of catalytic activity;GO:0051607|defense response to virus;",".","GO:0005096|GTPase activator activity;","K20654","TAGAP, ARHGAP47; T-cell activation Rho GTPase-activating protein"]
["ENSRNOG00000047867",592,38.08361941,1363,87.99781471,0.432779149,-1.208297101,{"v":1.71959e-70,"d":"1.72E-70"},{"v":7.58388e-70,"d":"7.58E-70"},"down","yes","Klhdc8b","protein_coding","chr8:109141594-109146918:-","gi|56090355|ref|NP_001007686.1|",1334,{"v":8e-173,"d":"8.00E-173"},"kelch domain-containing protein 8B [Rattus norvegicus]","gi|672062958|ref|XM_008766516.1|",1882,0,"PREDICTED: Rattus norvegicus kelch domain containing 8B (Klhdc8b), transcript variant X1, mRNA","Q5XIA9",518,{"v":2E-174,"d":"2.00E-174"},"Kelch domain-containing protein 8B",".",".",".",".","pfam01344","Kelch_1","Kelch motif. The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that the Drosophila ring canal kelch protein is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.","GO:0098813|nuclear chromosome segregation;GO:0140014|mitotic nuclear division;GO:1902410|mitotic cytokinetic process;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0030496|midbody;GO:0045171|intercellular bridge;GO:0110070|cellularization cleavage furrow;",".",".","."]
["ENSRNOG00000036603",109,7.012017762,543,35.05708979,0.200017109,-2.321804682,{"v":1.72589e-70,"d":"1.73E-70"},{"v":7.6058e-70,"d":"7.61E-70"},"down","yes","Ifit1bl","protein_coding","chr1:232122562-232167518:-","gi|293344709|ref|XP_001079971.2|",2456,0,"PREDICTED: interferon-induced protein with tetratricopeptide repeats 1 isoform X2 [Rattus norvegicus]","gi|672014796|ref|XM_001079971.4|",2564,0,"PREDICTED: Rattus norvegicus interferon-induced protein with tetratricopeptide repeats 1-like B (Ifit1lb), transcript variant X2, mRNA","Q64282",550,0,"Interferon-induced protein with tetratricopeptide repeats 1",".",".",".",".","pfam13414","TPR_11","TPR repeat.","GO:0050688|regulation of defense response to virus;GO:0051607|defense response to virus;GO:0071357|cellular response to type I interferon;GO:0071360|cellular response to exogenous dsRNA;","GO:0005829|cytosol;","GO:0003723|RNA binding;","K14217","IFIT1; interferon-induced protein with tetratricopeptide repeats 1"]
["ENSRNOG00000012482",232,14.92466166,780,50.35825053,0.296369741,-1.754529938,{"v":2.1833E-70,"d":"2.18E-70"},{"v":9.60672e-70,"d":"9.61E-70"},"down","yes","Ndrg4","protein_coding","chr19:9351404-9386914:-","gi|37360274|dbj|BAC98115.1|",1837,0,"mKIAA1180 protein [Mus musculus]","gi|402745959|ref|NM_001271091.1|",2861,0,"Rattus norvegicus NDRG family member 4 (Ndrg4), transcript variant 1, mRNA","Q6DIX1",623,0,"Protein NDRG4",".",".",".",".","pfam03096","Ndr","Ndr family. This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, and Ndr3. Their similarity was previously noted. The precise molecular and cellular function of members of this family is still unknown. Yet, they are known to be involved in cellular differentiation events. The Ndr1 group was the first to be discovered. Their expression is repressed by the proto-oncogenes N-myc and c-myc, and in line with this observation, Ndr1 protein expression is down-regulated in neoplastic cells, and is reactivated when differentiation is induced by chemicals such as retinoic acid. Ndr2 and Ndr3 expression is not under the control of N-myc or c-myc. Ndr1 expression is also activated by several chemicals: tunicamycin and homocysteine induce Ndr1 in human umbilical endothelial cells; nickel induces Ndr1 in several cell types. Members of this family are found in wide variety of multicellular eukaryotes, including an Ndr1 type protein in Helianthus annuus (sunflower), known as Sf21. Interestingly, the highest scoring matches in the noise are all alpha/beta hydrolases pfam00561, suggesting that this family may have an enzymatic function (Bateman A pers. obs.).","GO:0007165|signal transduction;GO:0007420|brain development;GO:0008542|visual learning;GO:0010642|negative regulation of platelet-derived growth factor receptor signaling pathway;GO:0010976|positive regulation of neuron projection development;GO:0014912|negative regulation of smooth muscle cell migration;GO:0048278|vesicle docking;GO:0048662|negative regulation of smooth muscle cell proliferation;GO:0060973|cell migration involved in heart development;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:2001135|regulation of endocytic recycling;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005789|endoplasmic reticulum membrane;GO:0005829|cytosol;GO:0016323|basolateral plasma membrane;GO:0031253|cell projection membrane;","GO:0003674|molecular_function;",".","."]
["ENSRNOG00000029141",49,3.152191471,404,26.0829913,0.120852376,-3.048682258,{"v":2.72239E-70,"d":"2.72E-70"},{"v":1.19695E-69,"d":"1.20E-69"},"down","yes","Trabd2b","protein_coding","chr5:127941114-128143747:+","gi|293359449|ref|XP_001072500.2|",2103,0,"PREDICTED: metalloprotease TIKI2 isoform X2 [Rattus norvegicus]","gi|672019750|ref|XM_003754079.3|",2095,0,"PREDICTED: Rattus norvegicus TraB domain containing 2B (Trabd2b), transcript variant X2, mRNA","A6NFA1",713,0,"Metalloprotease TIKI2","BMEI0146",60.5,1E-8,"COG3735","pfam01963","TraB","TraB family. pAD1 is a hemolysin/bacteriocin plasmid originally identified in Enterococcus faecalis DS16. It encodes a mating response to a peptide sex pheromone, cAD1, secreted by recipient bacteria. Once the plasmid pAD1 is acquired, production of the pheromone ceases--a trait related in part to a determinant designated traB. However a related protein is found in C. elegans, suggesting that members of the TraB family have some more general function. This family also includes the bacterial GumN protein. The family has a conserved GXXH motif close to the N-terminus, a conserved glutamate and a conserved arginine that may be catalytic. The family also includes a second conserved GXXH motif near the C-terminus.","GO:0006508|proteolysis;GO:0030178|negative regulation of Wnt signaling pathway;GO:0031334|positive regulation of protein complex assembly;GO:1904808|positive regulation of protein oxidation;","GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0031301|integral component of organelle membrane;","GO:0004222|metalloendopeptidase activity;GO:0017147|Wnt-protein binding;","K25185","TRABD2; metalloprotease TIKI [EC:3.4.-.-]"]
["ENSRNOG00000069879",312,20.07109671,918,59.26778716,0.338651022,-1.562128744,{"v":3.34706E-70,"d":"3.35E-70"},{"v":1.47047e-69,"d":"1.47E-69"},"down","yes","ENSRNOG00000069879","lncRNA","chr8:41961957-41963834:-","gi|148693587|gb|EDL25534.1|",260,{"v":8e-24,"d":"8.00E-24"},"mCG147890 [Mus musculus]","gi|730229405|ref|NR_126581.1|",1878,0,"Rattus norvegicus long non-coding RNA 215 (Lnc215), long non-coding RNA",".",".",".",".",".",".",".",".","pfam07454","SpoIIP","Stage II sporulation protein P (SpoIIP). This family contains the bacterial stage II sporulation protein P (SpoIIP) (approximately 350 residues long). It has been shown that a block in polar cytokinesis in Bacillus subtilis is mediated partly by transcription of spoIID, spoIIM and spoIIP. This inhibition of polar division is involved in the locking in of asymmetry after the formation of a polar septum during sporulation. Engulfment in Bacillus subtilis is mediated by two complementary systems: the first includes the proteins SpoIID, SpoIIM and SpoIIP (DMP) which carry out the engulfment, and the second includes the SpoIIQ-SpoIIIAGH (Q-AH) zipper, that recruits other proteins to the septum in a second-phase of the engulfment. The course of events follows as the incorporation firstly of SpoIIB into the septum during division to serve directly or indirectly as a landmark for localizing SpoIIM and then SpoIIP and SpoIID to the septum. SpoIIP and SpoIID interact together to form part of the DMP complex. SpoIIP itself has been identified as an autolysin with peptidoglycan hydrolase activity.",".",".",".",".","."]
["ENSRNOG00000002659",43,2.766208842,388,25.05000155,0.110427492,-3.178828707,{"v":3.6767e-70,"d":"3.68E-70"},{"v":1.61405E-69,"d":"1.61E-69"},"down","yes","Ciita","protein_coding","chr10:5140178-5187440:-","gi|399154121|ref|NP_001257732.1|",5282,0,"MHC class II transactivator isoform 2 [Rattus norvegicus]","gi|399154120|ref|NM_001270803.1|",4849,0,"Rattus norvegicus class II, major histocompatibility complex, transactivator (Ciita), transcript variant 2, mRNA","P79621",1878,0,"MHC class II transactivator",".",".",".",".","pfam05729","NACHT","NACHT domain. This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006954|inflammatory response;GO:0007568|aging;GO:0034341|response to interferon-gamma;GO:0045345|positive regulation of MHC class I biosynthetic process;GO:0045348|positive regulation of MHC class II biosynthetic process;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046597|negative regulation of viral entry into host cell;GO:0046677|response to antibiotic;GO:0071257|cellular response to electrical stimulus;GO:0071346|cellular response to interferon-gamma;GO:0071360|cellular response to exogenous dsRNA;","GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0009986|cell surface;GO:0016605|PML body;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0003674|molecular_function;GO:0005524|ATP binding;GO:0008022|protein C-terminus binding;GO:0044877|protein-containing complex binding;","K08060","CIITA; MHC class II transactivator [EC:2.7.11.1]"]
["ENSRNOG00000006231",36,2.315895775,369,23.82332621,0.097211269,-3.362732624,{"v":4.62755E-70,"d":"4.63E-70"},{"v":2.02835E-69,"d":"2.03E-69"},"down","yes","Ptpro","protein_coding","chr4:170164431-170374771:+","gi|8394227|ref|NP_059032.1|",6061,0,"receptor-type tyrosine-protein phosphatase O precursor [Rattus norvegicus]","gi|8394226|ref|NM_017336.1|",4850,0,"Rattus norvegicus protein tyrosine phosphatase, receptor type, O (Ptpro), mRNA","E9Q612",2241,0,"Receptor-type tyrosine-protein phosphatase O","SPAC11E3.09",168,{"v":2e-44,"d":"2.00E-44"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0000902|cell morphogenesis;GO:0002548|monocyte chemotaxis;GO:0003093|regulation of glomerular filtration;GO:0003105|negative regulation of glomerular filtration;GO:0007399|nervous system development;GO:0007411|axon guidance;GO:0030032|lamellipodium assembly;GO:0032835|glomerulus development;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0036060|slit diaphragm assembly;GO:0050807|regulation of synapse organization;GO:0072112|glomerular visceral epithelial cell differentiation;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:1990264|peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity;","GO:0005886|plasma membrane;GO:0016324|apical plasma membrane;GO:0016328|lateral plasma membrane;GO:0043197|dendritic spine;GO:0098978|glutamatergic synapse;GO:0098982|GABA-ergic synapse;GO:0099061|integral component of postsynaptic density membrane;","GO:0004725|protein tyrosine phosphatase activity;GO:0017147|Wnt-protein binding;GO:0042803|protein homodimerization activity;GO:0045296|cadherin binding;","K18035","PTPRO; receptor-type tyrosine-protein phosphatase O [EC:3.1.3.48]"]
["ENSRNOG00000042620",812,52.23631581,1682,108.5930479,0.481028176,-1.055806692,{"v":4.90277e-70,"d":"4.90E-70"},{"v":2.14733e-69,"d":"2.15E-69"},"down","yes","Marveld1","protein_coding","chr1:240954452-240958384:+","gi|157820241|ref|NP_001101060.1|",372,{"v":2e-38,"d":"2.00E-38"},"MARVEL domain-containing protein 1 [Rattus norvegicus]","gi|157820240|ref|NM_001107590.1|",2772,0,"Rattus norvegicus MARVEL domain containing 1 (Marveld1), mRNA","Q7TQJ1",99.4,{"v":6e-22,"d":"6.00E-22"},"MARVEL domain-containing protein 1",".",".",".",".","pfam09310","PD-C2-AF1","POU domain, class 2, associating factor 1. Members of this family are transcriptional coactivators that specifically associate with either OCT1 or OCT2, through recognition of their POU domains. They are essential for the response of B-cells to antigens and required for the formation of germinal centres.",".",".",".",".","."]
["ENSRNOG00000050090",19,1.222278326,321,20.72435695,0.058977865,-4.083682593,{"v":5.18915e-70,"d":"5.19E-70"},{"v":2.27102e-69,"d":"2.27E-69"},"down","yes","Slc6a17","protein_coding","chr2:195107438-195155697:-","gi|148669961|gb|EDL01908.1|",3652,0,"solute carrier family 6 (neurotransmitter transporter), member 17, isoform CRA_c, partial [Mus musculus]","gi|74271848|ref|NM_001033079.1|",6353,0,"Rattus norvegicus solute carrier family 6 member 17 (Slc6a17), mRNA","P31662",1385,0,"Sodium-dependent neutral amino acid transporter SLC6A17","VC2012",125,{"v":8e-29,"d":"8.00E-29"},"COG0733","pfam00209","SNF","Sodium:neurotransmitter symporter family.","GO:0006836|neurotransmitter transport;GO:0007420|brain development;GO:0015804|neutral amino acid transport;GO:0015816|glycine transport;GO:0015820|leucine transport;GO:0015824|proline transport;GO:0032328|alanine transport;GO:0035725|sodium ion transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0008021|synaptic vesicle;GO:0030285|integral component of synaptic vesicle membrane;GO:0031224|intrinsic component of membrane;GO:0042995|cell projection;GO:0098794|postsynapse;GO:0098978|glutamatergic synapse;GO:0098982|GABA-ergic synapse;","GO:0015293|symporter activity;","K05048","SLC6A15S; solute carrier family 6 (neurotransmitter transporter, amino acid/orphan) member 15/16/17/18/20"]
["ENSRNOG00000006151",19,1.222278326,320,20.65979509,0.059162171,-4.079181201,{"v":9.35992e-70,"d":"9.36E-70"},{"v":4.08384e-69,"d":"4.08E-69"},"down","yes","Reg3b","protein_coding","chr4:110861775-110865015:+","gi|16757982|ref|NP_445741.1|",879,{"v":8e-117,"d":"8.00E-117"},"regenerating islet-derived protein 3-beta precursor [Rattus norvegicus]","gi|298880697|emb|FQ233015.1|",770,0,"Rattus norvegicus TL0AEA63YI22 mRNA sequence","P25031",332,{"v":3e-114,"d":"3.00E-114"},"Regenerating islet-derived protein 3-beta",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0001934|positive regulation of protein phosphorylation;GO:0006953|acute-phase response;GO:0007494|midgut development;GO:0007565|female pregnancy;GO:0008284|positive regulation of cell proliferation;GO:0009617|response to bacterium;GO:0031667|response to nutrient levels;GO:0032355|response to estradiol;GO:0042594|response to starvation;GO:0043066|negative regulation of apoptotic process;GO:0043434|response to peptide hormone;GO:0043524|negative regulation of neuron apoptotic process;GO:0044278|cell wall disruption in other organism;GO:0044849|estrous cycle;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:0060548|negative regulation of cell death;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0071356|cellular response to tumor necrosis factor;GO:0071466|cellular response to xenobiotic stimulus;GO:1903208|negative regulation of hydrogen peroxide-induced neuron death;GO:1903577|cellular response to L-arginine;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0032991|protein-containing complex;GO:0042588|zymogen granule;GO:0045177|apical part of cell;","GO:0019838|growth factor binding;GO:0030246|carbohydrate binding;GO:0038023|signaling receptor activity;GO:0042802|identical protein binding;GO:0042834|peptidoglycan binding;GO:0070492|oligosaccharide binding;",".","."]
["ENSRNOG00000013387",691,44.45233279,1504,97.10103692,0.457794625,-1.127227571,{"v":1.19764e-69,"d":"1.20E-69"},{"v":5.22145e-69,"d":"5.22E-69"},"down","yes","Tpcn2","protein_coding","chr1:200416540-200446236:-","gi|157817292|ref|NP_001101036.1|",3130,0,"two pore calcium channel protein 2 [Rattus norvegicus]","gi|157817291|ref|NM_001107566.1|",2879,0,"Rattus norvegicus two pore segment channel 2 (Tpcn2), mRNA","Q8BWC0",1074,0,"Two pore calcium channel protein 2",".",".",".",".","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0006874|cellular calcium ion homeostasis;GO:0006939|smooth muscle contraction;GO:0007040|lysosome organization;GO:0010506|regulation of autophagy;GO:0017157|regulation of exocytosis;GO:0019065|receptor-mediated endocytosis of virus by host cell;GO:0019722|calcium-mediated signaling;GO:0033280|response to vitamin D;GO:0035725|sodium ion transmembrane transport;GO:0051209|release of sequestered calcium ion into cytosol;GO:0075509|endocytosis involved in viral entry into host cell;GO:0090117|endosome to lysosome transport of low-density lipoprotein particle;","GO:0005575|cellular_component;GO:0005764|lysosome;GO:0005765|lysosomal membrane;GO:0005829|cytosol;GO:0010008|endosome membrane;GO:0016021|integral component of membrane;GO:0036020|endolysosome membrane;","GO:0003674|molecular_function;GO:0005245|voltage-gated calcium channel activity;GO:0015280|ligand-gated sodium channel activity;GO:0019901|protein kinase binding;GO:0042802|identical protein binding;GO:0072345|NAADP-sensitive calcium-release channel activity;GO:0080025|phosphatidylinositol-3,5-bisphosphate binding;GO:0097682|intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity;","K14077","TPCN2; two pore calcium channel protein 2"]
["ENSRNOG00000012181",488,31.39325383,1198,77.34510787,0.405885449,-1.300855475,{"v":1.43166e-69,"d":"1.43E-69"},{"v":6.22273e-69,"d":"6.22E-69"},"down","yes","Lpl","protein_coding","chr16:20829465-20855249:-","gi|6981168|ref|NP_036730.1|",2466,0,"lipoprotein lipase precursor [Rattus norvegicus]","gi|205214|gb|L03294.1|RATLLIPA",3533,0,"Rattus norvegicus lipoprotein lipase mRNA, complete cds","Q06000",954,0,"Lipoprotein lipase",".",".",".",".","pfam00151","Lipase","Lipase.","GO:0006631|fatty acid metabolic process;GO:0006633|fatty acid biosynthetic process;GO:0009409|response to cold;GO:0009410|response to xenobiotic stimulus;GO:0009617|response to bacterium;GO:0010744|positive regulation of macrophage derived foam cell differentiation;GO:0010886|positive regulation of cholesterol storage;GO:0010890|positive regulation of sequestering of triglyceride;GO:0016042|lipid catabolic process;GO:0019432|triglyceride biosynthetic process;GO:0019433|triglyceride catabolic process;GO:0031670|cellular response to nutrient;GO:0032722|positive regulation of chemokine production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032755|positive regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0034371|chylomicron remodeling;GO:0034372|very-low-density lipoprotein particle remodeling;GO:0042632|cholesterol homeostasis;GO:0045600|positive regulation of fat cell differentiation;GO:0050729|positive regulation of inflammatory response;GO:0055096|low-density lipoprotein particle mediated signaling;GO:0070328|triglyceride homeostasis;GO:0071398|cellular response to fatty acid;GO:1900077|negative regulation of cellular response to insulin stimulus;GO:2000343|positive regulation of chemokine (C-X-C motif) ligand 2 production;","GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0034361|very-low-density lipoprotein particle;GO:0042627|chylomicron;","GO:0004465|lipoprotein lipase activity;GO:0004620|phospholipase activity;GO:0004806|triglyceride lipase activity;GO:0005102|signaling receptor binding;GO:0005509|calcium ion binding;GO:0008201|heparin binding;GO:0008970|phospholipase A1 activity;GO:0016298|lipase activity;GO:0017129|triglyceride binding;GO:0034185|apolipoprotein binding;GO:0042803|protein homodimerization activity;GO:0043395|heparan sulfate proteoglycan binding;GO:0052739|phosphatidylserine 1-acylhydrolase activity;GO:0052740|1-acyl-2-lysophosphatidylserine acylhydrolase activity;GO:0071813|lipoprotein particle binding;","K01059","LPL; lipoprotein lipase [EC:3.1.1.34]"]
["ENSRNOG00000005465",21,1.350939202,325,20.98260439,0.064383771,-3.957159104,{"v":1.48247E-69,"d":"1.48E-69"},{"v":6.43378e-69,"d":"6.43E-69"},"down","yes","Kcnmb1","protein_coding","chr10:18557904-18565798:+","gi|9506829|ref|NP_062146.1|",1031,{"v":4e-137,"d":"4.00E-137"},"calcium-activated potassium channel subunit beta-1 [Rattus norvegicus]","gi|9506828|ref|NM_019273.1|",1252,0,"Rattus norvegicus potassium calcium-activated channel subfamily M regulatory beta subunit 1 (Kcnmb1), mRNA","P97678",401,{"v":1e-138,"d":"1.00E-138"},"Calcium-activated potassium channel subunit beta-1",".",".",".",".","pfam03185","CaKB","Calcium-activated potassium channel, beta subunit.","GO:0005513|detection of calcium ion;GO:0007568|aging;GO:0042311|vasodilation;GO:0051592|response to calcium ion;GO:0071361|cellular response to ethanol;GO:0071456|cellular response to hypoxia;GO:0071805|potassium ion transmembrane transport;GO:1901381|positive regulation of potassium ion transmembrane transport;GO:1903413|cellular response to bile acid;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0008076|voltage-gated potassium channel complex;GO:0016021|integral component of membrane;","GO:0015269|calcium-activated potassium channel activity;GO:0015459|potassium channel regulator activity;","K04937","KCNMB1; potassium large conductance calcium-activated channel subfamily M beta member 1"]
["ENSRNOG00000003066",23,1.479600078,330,21.30541369,0.069447141,-3.847940878,{"v":2.31256E-69,"d":"2.31E-69"},{"v":9.9983e-69,"d":"1.00E-68"},"down","yes","Wnt9a","protein_coding","chr10:44094140-44121133:+","gi|21314846|ref|NP_647459.1|",1652,0,"protein Wnt-9a precursor [Mus musculus]","gi|672067726|ref|XM_006246448.2|",3342,0,"PREDICTED: Rattus norvegicus wingless-type MMTV integration site family, member 9A (Wnt9a), transcript variant X1, mRNA","Q8R5M2",640,0,"Protein Wnt-9a",".",".",".",".","pfam00110","wnt","wnt family. Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.","GO:0008150|biological_process;GO:0008285|negative regulation of cell proliferation;GO:0030182|neuron differentiation;GO:0032331|negative regulation of chondrocyte differentiation;GO:0035115|embryonic forelimb morphogenesis;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045165|cell fate commitment;GO:0045597|positive regulation of cell differentiation;GO:0045880|positive regulation of smoothened signaling pathway;GO:0048704|embryonic skeletal system morphogenesis;GO:0048856|anatomical structure development;GO:0060070|canonical Wnt signaling pathway;GO:0060548|negative regulation of cell death;GO:0061037|negative regulation of cartilage development;","GO:0005575|cellular_component;GO:0005615|extracellular space;","GO:0003674|molecular_function;GO:0005109|frizzled binding;GO:0005125|cytokine activity;GO:0048018|receptor ligand activity;","K01064","WNT9; wingless-type MMTV integration site family, member 9"]
["ENSRNOG00000017118",55,3.5381741,415,26.79317176,0.132055067,-2.920788432,{"v":2.64013E-69,"d":"2.64E-69"},{"v":1.13973e-68,"d":"1.14E-68"},"down","yes","P4ha3","protein_coding","chr1:154628736-154663775:+","gi|38454288|ref|NP_942070.1|",2715,0,"prolyl 4-hydroxylase subunit alpha-3 precursor [Rattus norvegicus]","gi|672037959|ref|XM_008759762.1|",2236,0,"PREDICTED: Rattus norvegicus prolyl 4-hydroxylase, alpha polypeptide III (P4ha3), transcript variant X2, mRNA","Q6W3E9",1048,0,"Prolyl 4-hydroxylase subunit alpha-3",".",".",".",".","pfam08336","P4Ha_N","Prolyl 4-Hydroxylase alpha-subunit, N-terminal region. The members of this family are eukaryotic proteins, and include all three isoforms of the prolyl 4-hydroxylase alpha subunit. This enzyme (EC:1.14.11.2) is important in the post-translational modification of collagen, as it catalyses the formation of 4-hydroxyproline. In vertebrates, the complete enzyme is an alpha2-beta2 tetramer; the beta-subunit is identical to protein disulphide isomerase. The function of the N-terminal region featured in this family does not seem to be known.","GO:0018401|peptidyl-proline hydroxylation to 4-hydroxy-L-proline;GO:0019511|peptidyl-proline hydroxylation;","GO:0005783|endoplasmic reticulum;GO:0005788|endoplasmic reticulum lumen;GO:0016222|procollagen-proline 4-dioxygenase complex;","GO:0004656|procollagen-proline 4-dioxygenase activity;GO:0005506|iron ion binding;GO:0031418|L-ascorbic acid binding;","K00472","P4HA; prolyl 4-hydroxylase [EC:1.14.11.2]"]
["ENSRNOG00000032396",14,0.900626135,303,19.56224348,0.046039,-4.440999681,{"v":4.44814e-69,"d":"4.45E-69"},{"v":1.91589E-68,"d":"1.92E-68"},"down","yes","RGD1559575","protein_coding","chr10:33252134-33276225:-","gi|109488030|ref|XP_220362.3|",4236,0,"PREDICTED: uncharacterized protein RGD1559575 [Rattus norvegicus]","gi|672024715|ref|XM_001070154.4|",2936,0,"PREDICTED: Rattus norvegicus similar to novel protein (RGD1559575), mRNA","Q3T9E4",521,{"v":1E-173,"d":"1.00E-173"},"T-cell-specific guanine nucleotide triphosphate-binding protein 2",".",".",".",".","pfam05049","IIGP","Interferon-inducible GTPase (IIGP). Interferon-inducible GTPase (IIGP) is thought to play a role in in intracellular defence. IIGP is predominantly associated with the Golgi apparatus and also localizes to the endoplasmic reticulum and exerts a distinct role in IFN-induced intracellular membrane trafficking or processing.","GO:0006952|defense response;GO:0035458|cellular response to interferon-beta;","GO:0005789|endoplasmic reticulum membrane;","GO:0003924|GTPase activity;GO:0005525|GTP binding;",".","."]
["ENSRNOG00000009211",28,1.801252269,343,22.14471786,0.081340041,-3.619890463,{"v":4.65734e-69,"d":"4.66E-69"},{"v":2.00448e-68,"d":"2.00E-68"},"down","yes","C3ar1","protein_coding","chr4:156075389-156084701:-","gi|564348849|ref|XP_006237376.1|",2466,0,"PREDICTED: C3a anaphylatoxin chemotactic receptor isoform X1 [Rattus norvegicus]","gi|14091739|ref|NM_032060.1|",1978,0,"Rattus norvegicus complement component 3a receptor 1 (C3ar1), mRNA","O55197",945,0,"C3a anaphylatoxin chemotactic receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0002430|complement receptor mediated signaling pathway;GO:0002462|tolerance induction to nonself antigen;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0008217|regulation of blood pressure;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0010759|positive regulation of macrophage chemotaxis;GO:0030335|positive regulation of cell migration;GO:0045766|positive regulation of angiogenesis;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0051482|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway;GO:0072126|positive regulation of glomerular mesangial cell proliferation;GO:0090023|positive regulation of neutrophil chemotaxis;GO:2000573|positive regulation of DNA biosynthetic process;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0001850|complement component C3a binding;GO:0004875|complement receptor activity;GO:0004876|complement component C3a receptor activity;GO:0004930|G protein-coupled receptor activity;","K04009","C3AR1; C3a anaphylatoxin chemotactic receptor"]
["ENSRNOG00000052981",345,22.19400117,966,62.36675643,0.355862681,-1.490607447,{"v":5.52323e-69,"d":"5.52E-69"},{"v":2.37537e-68,"d":"2.38E-68"},"down","yes","AABR07058464.1","protein_coding","chr7:109131064-109147649:-","gi|392341539|ref|XP_003754362.1|",1532,0,"PREDICTED: apolipoprotein L3-like isoform X1 [Rattus norvegicus]","gi|672022074|ref|XM_008776507.1|",1945,0,"PREDICTED: Rattus norvegicus apolipoprotein L3-like (LOC100910885), transcript variant X1, mRNA","O95236",195,{"v":8e-54,"d":"8.00E-54"},"Apolipoprotein L3",".",".",".",".","pfam05461","ApoL","Apolipoprotein L. Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.",".",".",".",".","."]
["ENSRNOG00000066282",54,3.473843662,411,26.53492432,0.130915906,-2.933287701,{"v":6.1663e-69,"d":"6.17E-69"},{"v":2.64794e-68,"d":"2.65E-68"},"down","yes","ENSRNOG00000066282","lncRNA","chr6:123705846-123712737:-","gi|149060974|gb|EDM11584.1|",131,1e-05,"rCG30389 [Rattus norvegicus]","gi|556695510|ref|NR_104436.1|",792,0,"Mus musculus calmin (Clmn), transcript variant 5, non-coding RNA",".",".",".",".",".",".",".",".","pfam04216","FdhE","Protein involved in formate dehydrogenase formation. The function of these proteins is unknown. They may possibly be involved in the formation of formate dehydrogenase.",".",".",".",".","."]
["ENSRNOG00000009910",625,40.20652387,1398,90.2574798,0.44546473,-1.166616885,{"v":1.95401E-68,"d":"1.95E-68"},{"v":8.34078e-68,"d":"8.34E-68"},"down","yes","Swap70","protein_coding","chr1:164267609-164328794:+","gi|157822537|ref|NP_001099758.1|",2741,0,"switch-associated protein 70 [Rattus norvegicus]","gi|157822536|ref|NM_001106288.1|",3864,0,"Rattus norvegicus SWAP switching B-cell complex 70 (Swap70), mRNA","Q6A028",1045,0,"Switch-associated protein 70",".",".",".",".","pfam00169","PH","PH domain. PH stands for pleckstrin homology.","GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0008064|regulation of actin polymerization or depolymerization;GO:0016444|somatic cell DNA recombination;GO:0030835|negative regulation of actin filament depolymerization;GO:0032233|positive regulation of actin filament bundle assembly;GO:0032880|regulation of protein localization;GO:0033633|negative regulation of cell-cell adhesion mediated by integrin;GO:0045190|isotype switching;GO:0051017|actin filament bundle assembly;GO:0060754|positive regulation of mast cell chemotaxis;GO:1902309|negative regulation of peptidyl-serine dephosphorylation;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0015629|actin cytoskeleton;","GO:0003677|DNA binding;GO:0005524|ATP binding;","K20072","SWAP70; switch-associated protein 70"]
["ENSRNOG00000010691",587,37.76196721,1341,86.5774538,0.436163984,-1.197057448,{"v":2.16306E-68,"d":"2.16E-68"},{"v":9.22622e-68,"d":"9.23E-68"},"down","yes","Cmtm3","protein_coding","chr19:604458-629790:-","gi|157818099|ref|NP_001099634.1|",905,{"v":1e-116,"d":"1.00E-116"},"CKLF-like MARVEL transmembrane domain-containing protein 3 [Rattus norvegicus]","gi|197246910|gb|BC169107.1|",1609,0,"Rattus norvegicus CKLF-like MARVEL transmembrane domain containing 3, mRNA (cDNA clone MGC:189531 IMAGE:7130835), complete cds","Q99LJ5",320,{"v":3e-105,"d":"3.00E-105"},"CKLF-like MARVEL transmembrane domain-containing protein 3",".",".",".",".","pfam01284","MARVEL","Membrane-associating domain. MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.","GO:0001835|blastocyst hatching;GO:0050861|positive regulation of B cell receptor signaling pathway;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016021|integral component of membrane;GO:0031410|cytoplasmic vesicle;GO:0031965|nuclear membrane;",".",".","."]
["ENSRNOG00000004346",532,34.22379311,1257,81.15425759,0.421712848,-1.245667118,{"v":2.90618e-68,"d":"2.91E-68"},{"v":1.23774E-67,"d":"1.24E-67"},"down","yes","Notch3","protein_coding","chr7:11133706-11184025:-","gi|9966775|ref|NP_064472.2|",10697,0,"neurogenic locus notch homolog protein 3 precursor [Rattus norvegicus]","gi|9966774|ref|NM_020087.2|",7274,0,"Rattus norvegicus notch 3 (Notch3), mRNA","Q9R172",4117,0,"Neurogenic locus notch homolog protein 3","TVN1399",66.6,{"v":7e-11,"d":"7.00E-11"},"COG0666","pfam07684","NODP","NOTCH protein. NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006355|regulation of transcription, DNA-templated;GO:0007219|Notch signaling pathway;GO:0007411|axon guidance;GO:0030900|forebrain development;GO:0042060|wound healing;GO:0042246|tissue regeneration;GO:0045596|negative regulation of cell differentiation;GO:0045665|negative regulation of neuron differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0048663|neuron fate commitment;GO:0048844|artery morphogenesis;GO:0072104|glomerular capillary formation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0015629|actin cytoskeleton;GO:0016021|integral component of membrane;GO:0043235|receptor complex;","GO:0005509|calcium ion binding;GO:0019899|enzyme binding;GO:0038023|signaling receptor activity;GO:0042802|identical protein binding;","K20995","NOTCH3; Notch 3"]
["ENSRNOG00000016308",93,5.982730751,498,32.15180611,0.186077595,-2.42602374,{"v":3.84815e-68,"d":"3.85E-68"},{"v":1.63648e-67,"d":"1.64E-67"},"down","yes","Il10ra","protein_coding","chr8:45563137-45578061:-","gi|340523096|ref|NP_476541.2|",2900,0,"interleukin-10 receptor subunit alpha precursor [Rattus norvegicus]","gi|672061584|ref|XM_006242864.2|",3339,0,"PREDICTED: Rattus norvegicus interleukin 10 receptor, alpha (Il10ra), transcript variant X1, mRNA","Q61727",885,0,"Interleukin-10 receptor subunit alpha",".",".",".",".","pfam01108","Tissue_fac","Tissue factor. This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.","GO:0010507|negative regulation of autophagy;GO:0019221|cytokine-mediated signaling pathway;GO:0032496|response to lipopolysaccharide;GO:0046427|positive regulation of JAK-STAT cascade;GO:0050807|regulation of synapse organization;GO:0070086|ubiquitin-dependent endocytosis;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004896|cytokine receptor activity;GO:0004920|interleukin-10 receptor activity;GO:0019969|interleukin-10 binding;","K05134","IL10RA, CD210A; interleukin 10 receptor alpha"]
["ENSRNOG00000017485",29,1.865582707,342,22.080156,0.084491373,-3.565052139,{"v":4.28439e-68,"d":"4.28E-68"},{"v":1.82065e-67,"d":"1.82E-67"},"down","yes","Cd72","protein_coding","chr5:57697367-57704725:-","gi|62543519|ref|NP_001015016.1|",1653,0,"B-cell differentiation antigen CD72 [Rattus norvegicus]","gi|62543518|ref|NM_001015016.1|",1473,0,"Rattus norvegicus Cd72 molecule (Cd72), mRNA","P21855",396,{"v":4e-133,"d":"4.00E-133"},"B-cell differentiation antigen CD72",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type",".","GO:0005887|integral component of plasma membrane;","GO:0004888|transmembrane signaling receptor activity;","K06504","CD72; CD72 antigen"]
["ENSRNOG00000017803",60,3.859826291,422,27.24510477,0.141670451,-2.819389212,{"v":4.76068e-68,"d":"4.76E-68"},{"v":2.02154e-67,"d":"2.02E-67"},"down","yes","Apbb1ip","protein_coding","chr17:84982243-85033010:+","gi|281332190|ref|NP_001094047.1|",2357,0,"amyloid beta A4 precursor protein-binding family B member 1-interacting protein [Rattus norvegicus]","gi|281332189|ref|NM_001100577.1|",2455,0,"Rattus norvegicus amyloid beta precursor protein binding family B member 1 interacting protein (Apbb1ip), mRNA","Q8R5A3",649,0,"Amyloid beta A4 precursor protein-binding family B member 1-interacting protein",".",".",".",".","pfam00788","RA","Ras association (RalGDS/AF-6) domain. RasGTP effectors (in cases of AF6, canoe and RalGDS); putative RasGTP effectors in other cases. Recent evidence (not yet in MEDLINE) shows that some RA domains do NOT bind RasGTP. Predicted structure similar to that determined, and that of the RasGTP-binding domain of Raf kinase.","GO:0002291|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0007165|signal transduction;GO:0045785|positive regulation of cell adhesion;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0042101|T cell receptor complex;",".","K17704","APBB1IP, RIAM; amyloid beta A4 precursor protein-binding family B member 1-interacting protein"]
["ENSRNOG00000046050",140,9.006261346,595,38.41430649,0.234450708,-2.092643461,{"v":5.33625e-68,"d":"5.34E-68"},{"v":2.26258e-67,"d":"2.26E-67"},"down","yes","ENSRNOG00000046050","protein_coding","chr9:1904045-1916187:-","gi|569001579|ref|XP_006524963.1|",3244,0,"PREDICTED: DENN domain-containing protein 1C isoform X3 [Mus musculus]","gi|187281974|ref|NM_001126289.1|",1732,0,"Rattus norvegicus DENN domain containing 1C (Dennd1c), mRNA","Q8CFK6",1245,0,"DENN domain-containing protein 1C",".",".",".",".","pfam02141","DENN","DENN (AEX-3) domain. DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.",".",".",".",".","."]
["ENSRNOG00000021039",1,0.064330438,327,21.11172811,0.003047142,-8.358327445,{"v":5.73979e-68,"d":"5.74E-68"},{"v":2.43008e-67,"d":"2.43E-67"},"down","yes","Fam83e","protein_coding","chr1:96191742-96201192:+","gi|109458759|ref|XP_218559.4|",1932,0,"PREDICTED: protein FAM83E [Rattus norvegicus]","gi|672013578|ref|XM_001079852.5|",3222,0,"PREDICTED: Rattus norvegicus family with sequence similarity 83, member E (Fam83e), mRNA","Q80XS7",693,0,"Protein FAM83E",".",".",".",".","pfam07894","DUF1669","Protein of unknown function (DUF1669). This family is composed of sequences derived from hypothetical eukaryotic proteins of unknown function. Some members of this family are annotated as being potential phospholipases but no literature was found to support this.","GO:0007165|signal transduction;",".","GO:0019901|protein kinase binding;","K23930","FAM83; protein FAM83"]
["ENSRNOG00000053811",43,2.766208842,379,24.46894481,0.113049781,-3.144969903,{"v":6.20581e-68,"d":"6.21E-68"},{"v":2.62543E-67,"d":"2.63E-67"},"down","yes","Arg2","protein_coding","chr6:97936002-97961378:+","gi|149051546|gb|EDM03719.1|",1800,0,"arginase 2 [Rattus norvegicus]","gi|9506398|ref|NM_019168.1|",1386,0,"Rattus norvegicus arginase 2 (Arg2), mRNA","O08701",691,0,"Arginase-2, mitochondrial","SPBP26C9.02c",221,{"v":2E-66,"d":"2.00E-66"},"COG0010","pfam00491","Arginase","Arginase family.","GO:0000050|urea cycle;GO:0001657|ureteric bud development;GO:0001666|response to hypoxia;GO:0002250|adaptive immune response;GO:0002829|negative regulation of type 2 immune response;GO:0006525|arginine metabolic process;GO:0006915|apoptotic process;GO:0006941|striated muscle contraction;GO:0007494|midgut development;GO:0007584|response to nutrient;GO:0009410|response to xenobiotic stimulus;GO:0009635|response to herbicide;GO:0009725|response to hormone;GO:0009749|response to glucose;GO:0010269|response to selenium ion;GO:0010963|regulation of L-arginine import;GO:0014075|response to amine;GO:0019547|arginine catabolic process to ornithine;GO:0030324|lung development;GO:0032651|regulation of interleukin-1 beta production;GO:0032696|negative regulation of interleukin-13 production;GO:0032700|negative regulation of interleukin-17 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0033197|response to vitamin E;GO:0043200|response to amino acid;GO:0045428|regulation of nitric oxide biosynthetic process;GO:0045988|negative regulation of striated muscle contraction;GO:0046686|response to cadmium ion;GO:0046689|response to mercury ion;GO:0048678|response to axon injury;GO:0051001|negative regulation of nitric-oxide synthase activity;GO:0060135|maternal process involved in female pregnancy;GO:0071222|cellular response to lipopolysaccharide;GO:0071346|cellular response to interferon-gamma;GO:0071353|cellular response to interleukin-4;GO:0071549|cellular response to dexamethasone stimulus;GO:0071641|negative regulation of macrophage inflammatory protein 1 alpha production;GO:0071644|negative regulation of chemokine (C-C motif) ligand 4 production;GO:0071650|negative regulation of chemokine (C-C motif) ligand 5 production;GO:1900425|negative regulation of defense response to bacterium;GO:1903426|regulation of reactive oxygen species biosynthetic process;GO:1905403|negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process;GO:2000562|negative regulation of CD4-positive, alpha-beta T cell proliferation;GO:2000774|positive regulation of cellular senescence;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;","GO:0004053|arginase activity;GO:0005515|protein binding;GO:0030145|manganese ion binding;GO:0046872|metal ion binding;GO:0050998|nitric-oxide synthase binding;","K01476","E3.5.3.1, rocF, arg; arginase [EC:3.5.3.1]"]
["ENSRNOG00000056697",252,16.21127042,802,51.77861144,0.313088165,-1.675359122,{"v":6.83215e-68,"d":"6.83E-68"},{"v":2.88827e-67,"d":"2.89E-67"},"down","yes","Kcnab1","protein_coding","chr2:149137041-149603534:+","gi|8393643|ref|NP_058999.1|",2145,0,"voltage-gated potassium channel subunit beta-1 [Rattus norvegicus]","gi|59709457|ref|NM_017303.2|",3487,0,"Rattus norvegicus potassium voltage-gated channel subfamily A member regulatory beta subunit 1 (Kcnab1), mRNA","P63144",830,0,"Voltage-gated potassium channel subunit beta-1","TM0313",333,{"v":3E-103,"d":"3.00E-103"},"COG0667","pfam00248","Aldo_ket_red","Aldo/keto reductase family. This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.","GO:0007420|brain development;GO:0007507|heart development;GO:0007519|skeletal muscle tissue development;GO:0007611|learning or memory;GO:0045445|myoblast differentiation;GO:0060539|diaphragm development;GO:0071805|potassium ion transmembrane transport;GO:1901016|regulation of potassium ion transmembrane transporter activity;GO:1901379|regulation of potassium ion transmembrane transport;GO:1902259|regulation of delayed rectifier potassium channel activity;GO:1902260|negative regulation of delayed rectifier potassium channel activity;GO:1903817|negative regulation of voltage-gated potassium channel activity;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0008076|voltage-gated potassium channel complex;GO:0016020|membrane;GO:0030424|axon;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0032839|dendrite cytoplasm;GO:0034705|potassium channel complex;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0044224|juxtaparanode region of axon;GO:1990635|proximal dendrite;","GO:0004033|aldo-keto reductase (NADP) activity;GO:0005249|voltage-gated potassium channel activity;GO:0005515|protein binding;GO:0015459|potassium channel regulator activity;GO:0019904|protein domain specific binding;GO:0044325|ion channel binding;GO:0047834|D-threo-aldose 1-dehydrogenase activity;GO:0070402|NADPH binding;","K04882","KCNAB1; potassium voltage-gated channel Shaker-related subfamily A, beta member 1"]
["ENSRNOG00000015773",32,2.058574022,349,22.53208902,0.09136188,-3.452263846,{"v":9.09317e-68,"d":"9.09E-68"},{"v":3.84127e-67,"d":"3.84E-67"},"down","yes","Il21r","protein_coding","chr1:180168097-180195522:+","gi|60223063|ref|NP_001012487.1|",2367,0,"interleukin-21 receptor precursor [Rattus norvegicus]","gi|672038437|ref|XM_006230262.2|",1741,0,"PREDICTED: Rattus norvegicus interleukin 21 receptor (Il21r), transcript variant X2, mRNA","Q9JHX3",809,0,"Interleukin-21 receptor",".",".",".",".","pfam01108","Tissue_fac","Tissue factor. This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.","GO:0008150|biological_process;GO:0019221|cytokine-mediated signaling pathway;","GO:0005575|cellular_component;GO:0016020|membrane;","GO:0003674|molecular_function;GO:0004888|transmembrane signaling receptor activity;GO:0004896|cytokine receptor activity;","K05075","IL21R, CD360; interleukin 21 receptor"]
["ENSRNOG00000025736",104,6.690365571,520,33.57216702,0.199283102,-2.327108714,{"v":9.22255e-68,"d":"9.22E-68"},{"v":3.89304e-67,"d":"3.89E-67"},"down","yes","Tcf23","protein_coding","chr6:25397937-25405880:-","gi|293359798|ref|XP_001067558.2|",872,{"v":2e-104,"d":"2.00E-104"},"PREDICTED: transcription factor 23 isoform X1 [Rattus norvegicus]","gi|672020455|ref|XM_003754152.3|",4040,0,"PREDICTED: Rattus norvegicus transcription factor 23 (Tcf23), transcript variant X1, mRNA","Q9JLR5",275,{"v":1e-82,"d":"1.00E-82"},"Transcription factor 23",".",".",".",".","pfam00010","HLH","Helix-loop-helix DNA-binding domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;GO:0010628|positive regulation of gene expression;GO:0032502|developmental process;GO:0046697|decidualization;GO:0051148|negative regulation of muscle cell differentiation;","GO:0000791|euchromatin;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0046983|protein dimerization activity;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;",".","."]
["ENSRNOG00000003310",85,5.468087246,478,30.86056892,0.177186858,-2.496656491,{"v":1.31278e-67,"d":"1.31E-67"},{"v":5.52928e-67,"d":"5.53E-67"},"down","yes","Tmem63a","protein_coding","chr13:92663968-92696183:+","gi|564382020|ref|XP_006250426.1|",3940,0,"PREDICTED: CSC1-like protein 1 isoform X2 [Rattus norvegicus]","gi|672075044|ref|XM_006250364.2|",3431,0,"PREDICTED: Rattus norvegicus transmembrane protein 63a (Tmem63a), transcript variant X1, mRNA","Q91YT8",1446,0,"CSC1-like protein 1",".",".",".",".","pfam02714","DUF221","Domain of unknown function DUF221. This family consists of hypothetical transmembrane proteins none of which have any function, the aligned region is at 538 residues at maximum length.","GO:0098655|cation transmembrane transport;","GO:0005765|lysosomal membrane;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0034451|centriolar satellite;GO:0043231|intracellular membrane-bounded organelle;","GO:0003676|nucleic acid binding;GO:0005227|calcium activated cation channel activity;GO:0008381|mechanosensitive ion channel activity;GO:1990760|osmolarity-sensing cation channel activity;","K21989","TMEM63, CSC1; calcium permeable stress-gated cation channel"]
["ENSRNOG00000008422",2,0.128660876,293,18.91662488,0.006801471,-7.199937474,{"v":1.58438e-67,"d":"1.58E-67"},{"v":6.66832e-67,"d":"6.67E-67"},"down","yes","Lpo","protein_coding","chr10:72606944-72626535:-","gi|157786856|ref|NP_001099299.1|",3652,0,"lactoperoxidase precursor [Rattus norvegicus]","gi|157786855|ref|NM_001105829.1|",2930,0,"Rattus norvegicus lactoperoxidase (Lpo), mRNA","Q8R481",1108,0,"Lactoperoxidase",".",".",".",".","pfam03098","An_peroxidase","Animal haem peroxidase.","GO:0001580|detection of chemical stimulus involved in sensory perception of bitter taste;GO:0006979|response to oxidative stress;GO:0018969|thiocyanate metabolic process;GO:0042742|defense response to bacterium;GO:0098869|cellular oxidant detoxification;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0016323|basolateral plasma membrane;","GO:0004601|peroxidase activity;GO:0020037|heme binding;GO:0036393|thiocyanate peroxidase activity;","K12550","LPO; lactoperoxidase [EC:1.11.1.7]"]
["ENSRNOG00000026504",786,50.56372441,1625,104.9130219,0.481958516,-1.05301912,{"v":1.92851e-67,"d":"1.93E-67"},{"v":8.10474e-67,"d":"8.10E-67"},"down","yes","Fam114a1","protein_coding","chr14:43275701-43346174:-","gi|564383732|ref|XP_006251053.1|",2419,0,"PREDICTED: protein NOXP20 isoform X2 [Rattus norvegicus]","gi|672076282|ref|XM_008770177.1|",1714,0,"PREDICTED: Rattus norvegicus family with sequence similarity 114, member A1 (Fam114a1), transcript variant X4, mRNA","Q9D281",812,0,"Protein Noxp20",".",".",".",".","pfam05334","DUF719","Protein of unknown function (DUF719). This family consists of several eukaryotic proteins of unknown function.",".","GO:0005654|nucleoplasm;GO:0005794|Golgi apparatus;GO:0005829|cytosol;",".",".","."]
["ENSRNOG00000038896",0,0.032165219,376,24.27525923,1.325021E-3,-9.559769471,{"v":1.97463e-67,"d":"1.97E-67"},{"v":8.29243e-67,"d":"8.29E-67"},"down","yes","Upk3bl1","protein_coding","chr12:20610353-20616366:-","gi|157824164|ref|NP_001102490.1|",1095,{"v":2e-147,"d":"2.00E-147"},"uroplakin 3B-like precursor [Rattus norvegicus]","gi|157824163|ref|NM_001109020.1|",975,0,"Rattus norvegicus uroplakin 3B-like (Upk3bl), mRNA","Q9D701",351,{"v":2E-119,"d":"2.00E-119"},"Uroplakin-3b-like protein 1",".",".",".",".","pfam12572","DUF3752","Protein of unknown function (DUF3752). This domain family is found in eukaryotes, and is typically between 140 and 163 amino acids in length.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000036711",48,3.087861033,389,25.11456341,0.122951014,-3.023844464,{"v":3.05406e-67,"d":"3.05E-67"},{"v":1.27879e-66,"d":"1.28E-66"},"down","yes","Spn","protein_coding","chr1:181746429-181759628:-","gi|402747140|ref|NP_001258015.1|",1433,{"v":2E-180,"d":"2.00E-180"},"leukosialin precursor [Rattus norvegicus]","gi|672038365|ref|XM_008759858.1|",4281,0,"PREDICTED: Rattus norvegicus sialophorin (Spn), transcript variant X2, mRNA","P13838",541,{"v":1E-176,"d":"1.00E-176"},"Leukosialin (Fragment)",".",".",".",".","pfam05109","Herpes_BLLF1","Herpes virus major outer envelope glycoprotein (BLLF1). This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralizing antibodies in vivo.","GO:0001562|response to protozoan;GO:0001808|negative regulation of type IV hypersensitivity;GO:0001934|positive regulation of protein phosphorylation;GO:0002296|T-helper 1 cell lineage commitment;GO:0002544|chronic inflammatory response;GO:0007162|negative regulation of cell adhesion;GO:0007166|cell surface receptor signaling pathway;GO:0010468|regulation of gene expression;GO:0031295|T cell costimulation;GO:0032760|positive regulation of tumor necrosis factor production;GO:0042102|positive regulation of T cell proliferation;GO:0042117|monocyte activation;GO:0042130|negative regulation of T cell proliferation;GO:0042742|defense response to bacterium;GO:0045060|negative thymic T cell selection;GO:0050688|regulation of defense response to virus;GO:0050776|regulation of immune response;GO:0050852|T cell receptor signaling pathway;GO:0050863|regulation of T cell activation;GO:0050868|negative regulation of T cell activation;GO:0050901|leukocyte tethering or rolling;GO:0071594|thymocyte aggregation;GO:0097190|apoptotic signaling pathway;GO:2000404|regulation of T cell migration;GO:2000406|positive regulation of T cell migration;","GO:0001931|uropod;GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0005887|integral component of plasma membrane;GO:0005902|microvillus;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016605|PML body;GO:0032154|cleavage furrow;","GO:0004888|transmembrane signaling receptor activity;GO:0005515|protein binding;GO:0019904|protein domain specific binding;GO:0030544|Hsp70 protein binding;GO:0031072|heat shock protein binding;","K06477","SPN, CD43; sialophorin"]
["ENSRNOG00000013907",6,0.385982629,277,17.88363512,0.021583007,-5.533960285,{"v":3.42342e-67,"d":"3.42E-67"},{"v":1.43239E-66,"d":"1.43E-66"},"down","yes","Sall1","protein_coding","chr19:18007503-18022705:+","gi|672084451|ref|XP_008770623.1|",5693,0,"PREDICTED: sal-like protein 1 isoform X2 [Rattus norvegicus]","gi|672084450|ref|XM_008772401.1|",5970,0,"PREDICTED: Rattus norvegicus spalt-like transcription factor 1 (Sall1), transcript variant X3, mRNA","Q9ER74",2082,0,"Sal-like protein 1",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001657|ureteric bud development;GO:0001658|branching involved in ureteric bud morphogenesis;GO:0001822|kidney development;GO:0001843|neural tube closure;GO:0003281|ventricular septum development;GO:0003337|mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0003340|negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007507|heart development;GO:0008150|biological_process;GO:0008406|gonad development;GO:0021553|olfactory nerve development;GO:0021772|olfactory bulb development;GO:0021889|olfactory bulb interneuron differentiation;GO:0021915|neural tube development;GO:0021983|pituitary gland development;GO:0030177|positive regulation of Wnt signaling pathway;GO:0030325|adrenal gland development;GO:0031129|inductive cell-cell signaling;GO:0035136|forelimb morphogenesis;GO:0035137|hindlimb morphogenesis;GO:0042733|embryonic digit morphogenesis;GO:0045666|positive regulation of neuron differentiation;GO:0045879|negative regulation of smoothened signaling pathway;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048566|embryonic digestive tract development;GO:0060173|limb development;GO:0061034|olfactory bulb mitral cell layer development;GO:0072073|kidney epithelium development;GO:0072092|ureteric bud invasion;GO:0072309|mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis;GO:0090190|positive regulation of branching involved in ureteric bud morphogenesis;GO:2000177|regulation of neural precursor cell proliferation;GO:2000381|negative regulation of mesoderm development;GO:2000384|negative regulation of ectoderm development;","GO:0000792|heterochromatin;GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0010369|chromocenter;GO:0016581|NuRD complex;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987|proximal promoter sequence-specific DNA binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0008013|beta-catenin binding;GO:0044877|protein-containing complex binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;","K19871","SALL; sal-like protein"]
["ENSRNOG00000026295",43,2.766208842,375,24.21069737,0.114255645,-3.12966265,{"v":6.03651e-67,"d":"6.04E-67"},{"v":2.5202E-66,"d":"2.52E-66"},"down","yes","Rbpjl","protein_coding","chr3:153134140-153146513:+","gi|157824061|ref|NP_001102074.1|",2659,0,"recombining binding protein suppressor of hairless-like protein [Rattus norvegicus]","gi|157824060|ref|NM_001108604.1|",2592,0,"Rattus norvegicus recombination signal binding protein for immunoglobulin kappa J region-like (Rbpjl), mRNA","O08674",986,0,"Recombining binding protein suppressor of hairless-like protein",".",".",".",".","pfam09270","BTD","Beta-trefoil DNA-binding domain. Members of this family of DNA binding domains adopt a beta-trefoil fold, that is, a capped beta-barrel with internal pseudo threefold symmetry. In the DNA-binding protein LAG-1, it also is the site of mutually exclusive interactions with NotchIC (and the viral protein EBNA2) and co-repressors (SMRT/N-Cor and CIR).","GO:0008150|biological_process;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0003682|chromatin binding;","K06053","RBPSUH, RBPJK; recombining binding protein suppressor of hairless"]
["ENSRNOG00000060773",53,3.409513224,400,25.82474386,0.132025055,-2.921116355,{"v":7.12046e-67,"d":"7.12E-67"},{"v":2.96624e-66,"d":"2.97E-66"},"down","yes","Sertad4","protein_coding","chr13:104360307-104370546:-","gi|157820889|ref|NP_001101821.1|",1736,0,"SERTA domain-containing protein 4 [Rattus norvegicus]","gi|157820888|ref|NM_001108351.1|",3197,0,"Rattus norvegicus SERTA domain containing 4 (Sertad4), mRNA","A7DTG3",600,0,"SERTA domain-containing protein 4",".",".",".",".","pfam06031","SERTA","SERTA motif. This family consists of a novel motif designated as SERTA (for SEI-1, RBT1, and TARA), corresponding to the largest conserved region among TRIP-Br proteins. The function of this motif is uncertain, but the CDK4-interacting segment of p34SEI-1 (amino acid residues 44-161) includes most of the SERTA motif.",".","GO:0005634|nucleus;",".",".","."]
["ENSRNOG00000009144",23,1.479600078,320,20.65979509,0.071617365,-3.803546758,{"v":8.31734e-67,"d":"8.32E-67"},{"v":3.44974e-66,"d":"3.45E-66"},"down","yes","Lad1","protein_coding","chr13:47249605-47263967:+","gi|189181736|ref|NP_001101412.2|",2332,0,"ladinin-1 [Rattus norvegicus]","gi|189181735|ref|NM_001107942.2|",2148,0,"Rattus norvegicus ladinin 1 (Lad1), mRNA","P57016",778,0,"Ladinin-1",".",".",".",".","pfam02029","Caldesmon","Caldesmon.",".","GO:0005576|extracellular region;GO:0005604|basement membrane;GO:0015629|actin cytoskeleton;","GO:0005198|structural molecule activity;",".","."]
["ENSRNOG00000055966",46,2.959200157,382,24.66263039,0.119987208,-3.059047491,{"v":9.00925e-67,"d":"9.01E-67"},{"v":3.73401e-66,"d":"3.73E-66"},"down","yes","AABR07062138.2","protein_coding","chr4:162296007-162339892:+","gi|564304456|ref|XP_002726503.2|",1182,{"v":3e-156,"d":"3.00E-156"},"PREDICTED: C-type lectin domain family 2 member D11 isoform X1 [Rattus norvegicus]","gi|672018794|ref|XM_002726457.3|",1252,0,"PREDICTED: Rattus norvegicus similar to osteoclast inhibitory lectin (LOC689800), transcript variant X1, mRNA","Q0H8B9",276,{"v":3e-87,"d":"3.00E-87"},"C-type lectin domain family 2 member D11",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type",".",".",".",".","."]
["ENSRNOG00000015674",113,7.269339515,534,34.47603306,0.210851971,-2.245697589,{"v":1.09513E-66,"d":"1.10E-66"},{"v":4.52907e-66,"d":"4.53E-66"},"down","yes","Acap1","protein_coding","chr10:54605323-54619472:-","gi|300390201|ref|NP_001099266.2|",3566,0,"arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 [Rattus norvegicus]","gi|300390200|ref|NM_001105796.2|",2468,0,"Rattus norvegicus ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 (Acap1), mRNA","Q8K2H4",1313,0,"Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1","SPBC17G9.08c_2",97.1,{"v":2e-21,"d":"2.00E-21"},"COG5347","pfam01412","ArfGap","Putative GTPase activating protein for Arf. Putative zinc fingers with GTPase activating proteins (GAPs) towards the small GTPase, Arf. The GAP of ARD1 stimulates GTPase hydrolysis for ARD1 but not ARFs.","GO:0050790|regulation of catalytic activity;",".","GO:0005096|GTPase activator activity;GO:0046872|metal ion binding;","K12489","ACAP; Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein"]
["ENSRNOG00000012622",143,9.19925266,594,38.34974464,0.239877807,-2.059628403,{"v":1.47756E-66,"d":"1.48E-66"},{"v":6.0974e-66,"d":"6.10E-66"},"down","yes","Mmp15","protein_coding","chr19:9663449-9684943:-","gi|157818219|ref|NP_001099638.1|",2797,0,"matrix metalloproteinase-15 precursor [Rattus norvegicus]","gi|158261997|ref|NM_001106168.2|",3818,0,"Rattus norvegicus matrix metallopeptidase 15 (Mmp15), mRNA","O54732",1064,0,"Matrix metalloproteinase-15",".",".",".",".","pfam00413","Peptidase_M10","Matrixin. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.","GO:0006508|proteolysis;GO:0030198|extracellular matrix organization;GO:0030574|collagen catabolic process;GO:0032355|response to estradiol;GO:0035987|endodermal cell differentiation;","GO:0005887|integral component of plasma membrane;GO:0031012|extracellular matrix;","GO:0004222|metalloendopeptidase activity;GO:0008270|zinc ion binding;","K07995","MMP15; matrix metalloproteinase-15 (membrane-inserted) [EC:3.4.24.-]"]
["ENSRNOG00000010045",10,0.643304382,282,18.20644442,0.035333883,-4.822803877,{"v":1.70757E-66,"d":"1.71E-66"},{"v":7.03133e-66,"d":"7.03E-66"},"down","yes","Clec4a","protein_coding","chr4:156414688-156432402:+","gi|148235584|ref|NP_001005899.2|",1106,{"v":2e-148,"d":"2.00E-148"},"C-type lectin domain family 4 member A [Rattus norvegicus]","gi|281332176|ref|NM_001170333.1|",545,0,"Mus musculus C-type lectin domain family 4, member a2 (Clec4a2), transcript variant 1, mRNA","Q67EQ0",426,{"v":2e-148,"d":"2.00E-148"},"C-type lectin domain family 4 member A",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0001818|negative regulation of cytokine production;GO:0001819|positive regulation of cytokine production;GO:0001878|response to yeast;GO:0001879|detection of yeast;GO:0002223|stimulatory C-type lectin receptor signaling pathway;GO:0002250|adaptive immune response;GO:0002470|plasmacytoid dendritic cell antigen processing and presentation;GO:0032720|negative regulation of tumor necrosis factor production;GO:0036037|CD8-positive, alpha-beta T cell activation;GO:0042590|antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045087|innate immune response;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050832|defense response to fungus;GO:0061760|antifungal innate immune response;GO:1902533|positive regulation of intracellular signal transduction;GO:2000318|positive regulation of T-helper 17 type immune response;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0005509|calcium ion binding;GO:0005537|mannose binding;GO:0030246|carbohydrate binding;GO:0038187|pattern recognition receptor activity;","K10057","CLEC4A, CD367; C-type lectin domain family 4 member A"]
["ENSRNOG00000006733",873,56.16047254,1740,112.3376358,0.499925712,-1.000214366,{"v":2.18719E-66,"d":"2.19E-66"},{"v":8.98685e-66,"d":"8.99E-66"},"down","yes","Srgap2","protein_coding","chr13:42745947-42967058:-","gi|672073799|ref|XP_008767701.1|",5088,0,"PREDICTED: SLIT-ROBO Rho GTPase-activating protein 2 isoform X4 [Rattus norvegicus]","gi|672073798|ref|XM_008769479.1|",3591,0,"PREDICTED: Rattus norvegicus SLIT-ROBO Rho GTPase activating protein 2 (Srgap2), transcript variant X5, mRNA","D4A208",1906,0,"SLIT-ROBO Rho GTPase-activating protein 2",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0003363|lamellipodium assembly involved in ameboidal cell migration;GO:0007165|signal transduction;GO:0007399|nervous system development;GO:0021816|extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration;GO:0030336|negative regulation of cell migration;GO:0034446|substrate adhesion-dependent cell spreading;GO:0043547|positive regulation of GTPase activity;GO:0046847|filopodium assembly;GO:0048812|neuron projection morphogenesis;GO:0051014|actin filament severing;GO:0060996|dendritic spine development;GO:2001223|negative regulation of neuron migration;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0030027|lamellipodium;GO:0044327|dendritic spine head;GO:0045211|postsynaptic membrane;GO:0045335|phagocytic vesicle;","GO:0005096|GTPase activator activity;GO:0031267|small GTPase binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;","K07526","SRGAP; SLIT-ROBO Rho GTPase activating protein"]
["ENSRNOG00000005620",115,7.398000391,536,34.60515678,0.213783178,-2.225779759,{"v":3.18507E-66,"d":"3.19E-66"},{"v":1.30776E-65,"d":"1.31E-65"},"down","yes","Lcp2","protein_coding","chr10:18642658-18689559:+","gi|18426850|ref|NP_569105.1|",2156,0,"lymphocyte cytosolic protein 2 [Rattus norvegicus]","gi|71896578|ref|NM_130421.2|",3361,0,"Rattus norvegicus lymphocyte cytosolic protein 2 (Lcp2), mRNA","Q60787",751,0,"Lymphocyte cytosolic protein 2",".",".",".",".","pfam00017","SH2","SH2 domain.","GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0035556|intracellular signal transduction;GO:0045576|mast cell activation;GO:0045860|positive regulation of protein kinase activity;GO:0050852|T cell receptor signaling pathway;","GO:0005829|cytosol;GO:0005911|cell-cell junction;GO:0036398|TCR signalosome;GO:0044853|plasma membrane raft;",".","K07361","LCP2; lymphocyte cytosolic protein 2"]
["ENSRNOG00000006579",37,2.380226213,356,22.98402204,0.103560039,-3.271460685,{"v":3.8953e-66,"d":"3.90E-66"},{"v":1.59479E-65,"d":"1.59E-65"},"down","yes","Reg3g","protein_coding","chr4:110924168-110926723:-","gi|672050048|ref|XP_008761241.1|",871,{"v":5e-115,"d":"5.00E-115"},"PREDICTED: regenerating islet-derived protein 3-gamma isoform X1 [Rattus norvegicus]","gi|27465526|ref|NM_173097.1|",773,0,"Rattus norvegicus regenerating family member 3 gamma (Reg3g), mRNA","P42854",324,{"v":4e-111,"d":"4.00E-111"},"Regenerating islet-derived protein 3-gamma",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0002755|MyD88-dependent toll-like receptor signaling pathway;GO:0006953|acute-phase response;GO:0008284|positive regulation of cell proliferation;GO:0009617|response to bacterium;GO:0010838|positive regulation of keratinocyte proliferation;GO:0043434|response to peptide hormone;GO:0044278|cell wall disruption in other organism;GO:0045617|negative regulation of keratinocyte differentiation;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:0051838|cytolysis by host of symbiont cells;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0090303|positive regulation of wound healing;","GO:0005615|extracellular space;GO:0030141|secretory granule;","GO:0038023|signaling receptor activity;GO:0042834|peptidoglycan binding;GO:0070492|oligosaccharide binding;",".","."]
["ENSRNOG00000019262",777,49.98475047,1602,103.4280992,0.483280181,-1.049068263,{"v":4.07453e-66,"d":"4.07E-66"},{"v":1.66697E-65,"d":"1.67E-65"},"down","yes","Trak1","protein_coding","chr8:120984431-121139367:+","gi|568964078|ref|XP_006512296.1|",3466,0,"PREDICTED: trafficking kinesin-binding protein 1 isoform X9 [Mus musculus]","gi|672063607|ref|XM_006244103.2|",2838,0,"PREDICTED: Rattus norvegicus trafficking protein, kinesin binding 1 (Trak1), transcript variant X6, mRNA","Q6PD31",1038,0,"Trafficking kinesin-binding protein 1",".",".",".",".","pfam04849","HAP1_N","HAP1 N-terminal conserved region. This family represents an N-terminal conserved region found in several huntingtin-associated protein 1 (HAP1) homologues. HAP1 binds to huntingtin in a polyglutamine repeat-length-dependent manner. However, its possible role in the pathogenesis of Huntington's disease is unclear. This family also includes a similar N-terminal conserved region from hypothetical protein products of ALS2CR3 genes found in the human juvenile amyotrophic lateral sclerosis critical region 2q33-2q34.","GO:0006605|protein targeting;GO:0008333|endosome to lysosome transport;GO:0019896|axonal transport of mitochondrion;GO:0022008|neurogenesis;GO:0047496|vesicle transport along microtubule;GO:0048311|mitochondrion distribution;GO:0048813|dendrite morphogenesis;GO:0050772|positive regulation of axonogenesis;GO:0098957|anterograde axonal transport of mitochondrion;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005769|early endosome;GO:0030425|dendrite;GO:0031410|cytoplasmic vesicle;GO:0044295|axonal growth cone;GO:0048471|perinuclear region of cytoplasm;GO:1904115|axon cytoplasm;","GO:0005102|signaling receptor binding;GO:0016740|transferase activity;GO:0017022|myosin binding;GO:0030911|TPR domain binding;GO:0050811|GABA receptor binding;","K15369","TRAK1; trafficking kinesin-binding protein 1"]
["ENSRNOG00000037409",38,2.444556651,358,23.11314576,0.105764775,-3.241068883,{"v":5.66348e-66,"d":"5.66E-66"},{"v":2.31538E-65,"d":"2.32E-65"},"down","yes","Scimp","protein_coding","chr10:55507519-55528171:-","gi|293351630|ref|XP_001080739.2|",669,{"v":3e-82,"d":"3.00E-82"},"PREDICTED: SLP adapter and CSK-interacting membrane protein isoform X2 [Rattus norvegicus]","gi|672024902|ref|XM_003752341.3|",1057,0,"PREDICTED: Rattus norvegicus SLP adaptor and CSK interacting membrane protein (Scimp), transcript variant X1, mRNA","Q3UU41",220,{"v":2e-67,"d":"2.00E-67"},"SLP adapter and CSK-interacting membrane protein",".",".",".",".","pfam15050","SCIMP","SCIMP protein. This family contains the SCIMP proteins which are a a transmembrane adaptor protein involved in major histocompatibility complex class II signaling.","GO:0002720|positive regulation of cytokine production involved in immune response;GO:0002732|positive regulation of dendritic cell cytokine production;GO:0031666|positive regulation of lipopolysaccharide-mediated signaling pathway;GO:0032735|positive regulation of interleukin-12 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032874|positive regulation of stress-activated MAPK cascade;GO:0034138|toll-like receptor 3 signaling pathway;GO:0034142|toll-like receptor 4 signaling pathway;GO:0034154|toll-like receptor 7 signaling pathway;GO:0038123|toll-like receptor TLR1:TLR2 signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071226|cellular response to molecule of fungal origin;","GO:0001726|ruffle;GO:0001772|immunological synapse;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030175|filopodium;GO:0031256|leading edge membrane;GO:0031259|uropod membrane;GO:0043235|receptor complex;GO:0045335|phagocytic vesicle;GO:0097197|tetraspanin-enriched microdomain;","GO:0060090|molecular adaptor activity;",".","."]
["ENSRNOG00000024120",2,0.128660876,285,18.40013,0.00699239,-7.159998728,{"v":6.5973e-66,"d":"6.60E-66"},{"v":2.68945e-65,"d":"2.69E-65"},"down","yes","Rxfp1","protein_coding","chr2:164774799-164893412:-","gi|564336861|ref|XP_006232570.1|",3912,0,"PREDICTED: relaxin receptor 1 isoform X1 [Rattus norvegicus]","gi|672042666|ref|XM_006232508.2|",2935,0,"PREDICTED: Rattus norvegicus relaxin/insulin-like family peptide receptor 1 (Rxfp1), transcript variant X1, mRNA","Q6R6I6",1502,0,"Relaxin receptor 1","SPy1798",96.3,{"v":3e-19,"d":"3.00E-19"},"COG4886","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007188|adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007190|activation of adenylate cyclase activity;GO:0007567|parturition;GO:0009755|hormone-mediated signaling pathway;GO:0030154|cell differentiation;GO:0030198|extracellular matrix organization;GO:0060427|lung connective tissue development;GO:0060658|nipple morphogenesis;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0008528|G protein-coupled peptide receptor activity;GO:0042562|hormone binding;GO:0046872|metal ion binding;","K04306","RXFP1, LGR7; relaxin family peptide receptor 1"]
["ENSRNOG00000051534",6,0.385982629,271,17.49626397,0.02206086,-5.50236716,{"v":9.59246e-66,"d":"9.59E-66"},{"v":3.9021e-65,"d":"3.90E-65"},"down","yes","Prr33","protein_coding","chr1:197644902-197650714:-","gi|109459666|ref|XP_001064406.1|",1750,0,"PREDICTED: proline-rich protein 33 [Rattus norvegicus]","gi|672014503|ref|XM_002725732.4|",2140,0,"PREDICTED: Rattus norvegicus hypothetical protein LOC685580 (LOC685580), transcript variant X1, mRNA","Q8C494",341,{"v":4e-110,"d":"4.00E-110"},"Proline-rich protein 33",".",".",".",".","pfam15485","DUF4643","Domain of unknown function (DUF4643). This family of proteins is found in eukaryotes. Proteins in this family are typically between 254 and 462 amino acids in length.","GO:0009611|response to wounding;",".",".",".","."]
["ENSRNOG00000026604",318,20.45707934,902,58.23479741,0.351286177,-1.509281287,{"v":1.05765e-65,"d":"1.06E-65"},{"v":4.29933e-65,"d":"4.30E-65"},"down","yes","Cercam","protein_coding","chr3:13142107-13155956:+","gi|564339925|ref|XP_006233830.1|",2973,0,"PREDICTED: probable inactive glycosyltransferase 25 family member 3 isoform X1 [Rattus norvegicus]","gi|672044888|ref|XM_006233770.2|",2315,0,"PREDICTED: Rattus norvegicus cerebral endothelial cell adhesion molecule (Cercam), transcript variant X1, mRNA","A3KGW5",1093,0,"Inactive glycosyltransferase 25 family member 3",".",".",".",".","pfam01755","Glyco_transf_25","Glycosyltransferase family 25 (LPS biosynthesis protein). Members of this family belong to Glycosyltransferase family 25 This is a family of glycosyltransferases involved in lipopolysaccharide (LPS) biosynthesis. These enzymes catalyse the transfer of various sugars onto the growing LPS chain during its biosynthesis.","GO:0007155|cell adhesion;","GO:0005788|endoplasmic reticulum lumen;","GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000012965",39,2.508887089,359,23.17770762,0.108245696,-3.207618434,{"v":1.44562e-65,"d":"1.45E-65"},{"v":5.86808e-65,"d":"5.87E-65"},"down","yes","Themis2","protein_coding","chr5:144991112-145006400:-","gi|407228396|ref|NP_001258409.1|",3198,0,"protein THEMIS2 [Rattus norvegicus]","gi|407228395|ref|NM_001271480.1|",1974,0,"Rattus norvegicus thymocyte selection associated family member 2 (Themis2), mRNA","Q91YX0",1058,0,"Protein THEMIS2",".",".",".",".","pfam12736","CABIT","Cell-cycle sustaining, positive selection,. The 'CABIT' domain (for 'cysteine-containing, all- in Themis') is found in a newly identified gene family that has three mammalian homologues (Themis, Icb1 and 9130404H23Rik) that encode proteins with two CABIT domains and a highly conserved proline-rich region. In contrast, Fam59A, Fam59B and related proteins from mammals to cnidarians, including the insect Serrano proteins, have a single copy of the CABIT domain, a proline-rich region and often a C-terminal SAM (sterile-motif) domain. Multiple-sequence alignment has predicted that the CABIT domain adopts an all-strand structure with at least 12 strands, ie a dyad of six-stranded beta-barrel units. The CABIT domain contains a nearly absolutely conserved cysteine residue which is likely to be central to its function. CABIT domain proteins function downstream of tyrosine kinase signalling and interact with GRB2.","GO:0050852|T cell receptor signaling pathway;GO:0050864|regulation of B cell activation;","GO:0005634|nucleus;GO:0005737|cytoplasm;",".",".","."]
["ENSRNOG00000016099",516,33.1945061,1214,78.37809762,0.423517629,-1.23950607,{"v":1.70837e-65,"d":"1.71E-65"},{"v":6.91497e-65,"d":"6.91E-65"},"down","yes","Id4","protein_coding","chr17:16389387-16392470:-","gi|28212236|ref|NP_783172.1|",587,{"v":6E-68,"d":"6.00E-68"},"DNA-binding protein inhibitor ID-4 [Rattus norvegicus]","gi|28212235|ref|NM_175582.1|",1579,0,"Rattus norvegicus inhibitor of DNA binding 4, dominant negative helix-loop-helix protein (Id4), mRNA","P47928",218,{"v":7e-65,"d":"7.00E-65"},"DNA-binding protein inhibitor ID-4",".",".",".",".","pfam00010","HLH","Helix-loop-helix DNA-binding domain.","GO:0000082|G1/S transition of mitotic cell cycle;GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001649|osteoblast differentiation;GO:0007405|neuroblast proliferation;GO:0007420|brain development;GO:0007623|circadian rhythm;GO:0008284|positive regulation of cell proliferation;GO:0010628|positive regulation of gene expression;GO:0021766|hippocampus development;GO:0021895|cerebral cortex neuron differentiation;GO:0022010|central nervous system myelination;GO:0030154|cell differentiation;GO:0032922|circadian regulation of gene expression;GO:0034613|cellular protein localization;GO:0045444|fat cell differentiation;GO:0045599|negative regulation of fat cell differentiation;GO:0045665|negative regulation of neuron differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048712|negative regulation of astrocyte differentiation;GO:0048715|negative regulation of oligodendrocyte differentiation;GO:0060512|prostate gland morphogenesis;GO:0060740|prostate gland epithelium morphogenesis;GO:0060741|prostate gland stromal morphogenesis;GO:0061682|seminal vesicle morphogenesis;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;","GO:0046983|protein dimerization activity;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;GO:0140110|transcription regulator activity;","K17695","ID4; DNA-binding protein inhibitor ID4"]
["ENSRNOG00000029145",216,13.89537465,724,46.74278639,0.297273135,-1.750139004,{"v":3.03003e-65,"d":"3.03E-65"},{"v":1.223e-64,"d":"1.22E-64"},"down","yes","AY172581.2","Mt_tRNA","chrMT:15348-15415:-",".",".",".",".","gi|755572967|gb|KP244683.1|",68,{"v":2e-26,"d":"2.00E-26"},"Rattus norvegicus isolate 115 mitochondrion, complete genome",".",".",".",".",".",".",".",".","pfam02514","CobN-Mg_chel","CobN/Magnesium Chelatase. This family contains a domain common to the cobN protein and to magnesium protoporphyrin chelatase. CobN is implicated in the conversion of hydrogenobyrinic acid a,c-diamide to cobyrinic acid. Magnesium protoporphyrin chelatase is involved in chlorophyll biosynthesis.",".",".",".",".","."]
["ENSRNOG00000052199",132,8.49161784,565,36.47745071,0.23279088,-2.102893557,{"v":4.68589e-65,"d":"4.69E-65"},{"v":1.88735e-64,"d":"1.89E-64"},"down","yes","Zcwpw1","protein_coding","chr12:18880633-18910711:-","gi|392332566|ref|XP_003752622.1|",2959,0,"PREDICTED: zinc finger CW-type PWWP domain protein 1-like isoform X1 [Rattus norvegicus]","gi|672026628|ref|XM_003752574.3|",2268,0,"PREDICTED: Rattus norvegicus zinc finger CW-type PWWP domain protein 1-like (LOC100910636), transcript variant X1, mRNA","Q6IR42",948,0,"Zinc finger CW-type PWWP domain protein 1",".",".",".",".","pfam00855","PWWP","PWWP domain. The PWWP domain is named after a conserved Pro-Trp-Trp-Pro motif. The domain binds to Histone-4 methylated at lysine-20, H4K20me, suggesting that it is methyl-lysine recognition motif. Removal of two conserved aromatic residues in a hydrophobic cavity created by this domain within the full-length protein, Pdp1, abolishes the interaction o f the protein with H4K20me3. In fission yeast, Set9 is the sole enzyme that catalyses all three states of H4K20me, and Set9-mediated H4K20me is required for efficient recruitment of checkpoint protein Crb2 to sites of DNA damage. The methylation of H4K20 is involved in a diverse array of cellular processes, such as organizing higher-order chromatin, maintaining genome stability, and regulating cell-cycle progression.","GO:0007127|meiosis I;GO:0007129|synapsis;GO:0007283|spermatogenesis;GO:0045911|positive regulation of DNA recombination;GO:2000781|positive regulation of double-strand break repair;","GO:0001741|XY body;GO:0005634|nucleus;","GO:0008270|zinc ion binding;GO:0008327|methyl-CpG binding;GO:0035064|methylated histone binding;","K24688","ZCWPW1; zinc finger CW-type PWWP domain protein 1"]
["ENSRNOG00000066065",734,47.21854163,1532,98.90876899,0.477394897,-1.066744948,{"v":5.22515e-65,"d":"5.23E-65"},{"v":2.10306E-64,"d":"2.10E-64"},"down","yes","Basp1","protein_coding","chr2:75816122-75864043:-","gi|344246100|gb|EGW02204.1|",212,{"v":6e-17,"d":"6.00E-17"},"hypothetical protein I79_011772 [Cricetulus griseus]","gi|224586937|ref|NM_027395.2|",1500,0,"Mus musculus brain abundant, membrane attached signal protein 1 (Basp1), mRNA",".",".",".",".",".",".",".",".","pfam02665","Nitrate_red_gam","Nitrate reductase gamma subunit. This family is the gamma subunit of the nitrate reductase enzyme, the gamma subunit is a b-type cytochrome that receives electrons from the quinone pool.  It then transfers these via the iron-sulfur clusters of the beta subunit to the molybdenum cofactor found in the alpha subunit. The nitrate reductase enzyme, EC:1.7.99.4 catalyses the conversion of nitrite to nitrate via the reduction of an acceptor. The nitrate reductase enzyme is composed of three subunits. Nitrate is the most widely used alternative electron acceptor after oxygen.",".",".",".",".","."]
["ENSRNOG00000020501",84,5.403756808,464,29.95670288,0.180385566,-2.470844192,{"v":6.24645e-65,"d":"6.25E-65"},{"v":2.51059E-64,"d":"2.51E-64"},"down","yes","Tjp3","protein_coding","chr7:8432811-8446279:+","gi|564358162|ref|XP_006240994.1|",4263,0,"PREDICTED: tight junction protein ZO-3 isoform X1 [Rattus norvegicus]","gi|157821080|ref|NM_001108073.1|",2937,0,"Rattus norvegicus tight junction protein 3 (Tjp3), mRNA","Q9QXY1",1515,0,"Tight junction protein ZO-3",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.","GO:0045216|cell-cell junction organization;GO:0090557|establishment of endothelial intestinal barrier;GO:0098609|cell-cell adhesion;GO:1905605|positive regulation of maintenance of permeability of blood-brain barrier;GO:2000045|regulation of G1/S transition of mitotic cell cycle;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0005923|bicellular tight junction;GO:0009986|cell surface;GO:0016324|apical plasma membrane;GO:0030054|cell junction;GO:0070160|tight junction;","GO:0050839|cell adhesion molecule binding;","K06097","TJP3, ZO3; tight junction protein 3"]
["ENSRNOG00000000907",51,3.280852347,385,24.85631597,0.131992704,-2.921469913,{"v":1.92171e-64,"d":"1.92E-64"},{"v":7.7075e-64,"d":"7.71E-64"},"down","yes","Alox5ap","protein_coding","chr12:5748944-5772986:-","gi|8392897|ref|NP_058956.1|",767,{"v":3e-99,"d":"3.00E-99"},"arachidonate 5-lipoxygenase-activating protein [Rattus norvegicus]","gi|55926225|ref|NM_017260.2|",934,0,"Rattus norvegicus arachidonate 5-lipoxygenase activating protein (Alox5ap), mRNA","P20291",300,{"v":1E-100,"d":"1.00E-100"},"Arachidonate 5-lipoxygenase-activating protein",".",".",".",".","pfam01124","MAPEG","MAPEG family. This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolizm). It includes proteins such as Prostaglandin E synthase. This enzyme catalyses the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.","GO:0002540|leukotriene production involved in inflammatory response;GO:0002675|positive regulation of acute inflammatory response;GO:0019370|leukotriene biosynthetic process;GO:0019372|lipoxygenase pathway;GO:0050790|regulation of catalytic activity;GO:0070207|protein homotrimerization;GO:0071277|cellular response to calcium ion;GO:0098869|cellular oxidant detoxification;","GO:0005634|nucleus;GO:0005635|nuclear envelope;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005829|cytosol;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0031965|nuclear membrane;","GO:0004051|arachidonate 5-lipoxygenase activity;GO:0004364|glutathione transferase activity;GO:0004464|leukotriene-C4 synthase activity;GO:0004602|glutathione peroxidase activity;GO:0008047|enzyme activator activity;GO:0019899|enzyme binding;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;GO:0047485|protein N-terminus binding;GO:0050544|arachidonic acid binding;","K20735","ALOX5AP, FLAP; arachidonate 5-lipoxygenase-activating protein"]
["ENSRNOG00000009448",325,20.90739241,906,58.49304485,0.357433819,-1.484251951,{"v":2.04405E-64,"d":"2.04E-64"},{"v":8.19e-64,"d":"8.19E-64"},"down","yes","Papln","protein_coding","chr6:103398838-103432206:+","gi|672020961|ref|XP_008774518.1|",6637,0,"PREDICTED: papilin isoform X4 [Rattus norvegicus]","gi|672020960|ref|XM_008776296.1|",6501,0,"PREDICTED: Rattus norvegicus papilin, proteoglycan-like sulfated glycoprotein (Papln), transcript variant X6, mRNA","Q9EPX2",2267,0,"Papilin",".",".",".",".","pfam05986","ADAM_spacer1","ADAM-TS Spacer 1. This family represents the Spacer-1 region from the ADAM-TS family of metalloproteinases.","GO:0006508|proteolysis;GO:0010951|negative regulation of endopeptidase activity;GO:0030198|extracellular matrix organization;","GO:0005576|extracellular region;GO:0005604|basement membrane;GO:0031012|extracellular matrix;","GO:0004222|metalloendopeptidase activity;GO:0004867|serine-type endopeptidase inhibitor activity;","K23624","PAPLN; papilin"]
["ENSRNOG00000008401",240,15.43930516,762,49.19613706,0.313831656,-1.671937211,{"v":2.04488e-64,"d":"2.04E-64"},{"v":8.19e-64,"d":"8.19E-64"},"down","yes","Card10","protein_coding","chr7:110330408-110359224:-","gi|564360967|ref|XP_006242048.1|",4751,0,"PREDICTED: caspase recruitment domain-containing protein 10 isoform X2 [Rattus norvegicus]","gi|672059979|ref|XM_006241986.2|",4083,0,"PREDICTED: Rattus norvegicus caspase recruitment domain family, member 10 (Card10), transcript variant X1, mRNA","P58660",1752,0,"Caspase recruitment domain-containing protein 10",".",".",".",".","pfam00619","CARD","Caspase recruitment domain. Motif contained in proteins involved in apoptotic signaling. Predicted to possess a DEATH (pfam00531) domain-like fold.","GO:0007250|activation of NF-kappaB-inducing kinase activity;GO:0042981|regulation of apoptotic process;GO:0090051|negative regulation of cell migration involved in sprouting angiogenesis;GO:1900182|positive regulation of protein localization to nucleus;","GO:0005737|cytoplasm;","GO:0050700|CARD domain binding;","K20912","CARD10; caspase recruitment domain-containing protein 10"]
["ENSRNOG00000021424",20,1.286608764,301,19.43311976,0.06620701,-3.916872201,{"v":3.78002e-64,"d":"3.78E-64"},{"v":1.51182E-63,"d":"1.51E-63"},"down","yes","Cd300lf","protein_coding","chr10:100359943-100376041:-","gi|68341985|ref|NP_001020282.1|",1394,0,"CMRF35-like molecule 1 precursor [Rattus norvegicus]","gi|68341984|ref|NM_001025111.1|",1786,0,"Rattus norvegicus Cd300 molecule-like family member F (Cd300lf), mRNA","Q566E6",541,0,"CMRF35-like molecule 1",".",".",".",".","pfam15330","SIT","SHP2-interacting transmembrane adaptor protein, SIT. SIT, or SHP2-interacting transmembrane adaptor protein, is a disulfide-linked dimer that regulates human T Cell activation.","GO:0030316|osteoclast differentiation;GO:0033004|negative regulation of mast cell activation;GO:0034125|negative regulation of MyD88-dependent toll-like receptor signaling pathway;GO:0035666|TRIF-dependent toll-like receptor signaling pathway;GO:0035772|interleukin-13-mediated signaling pathway;GO:0046718|viral entry into host cell;GO:1902216|positive regulation of interleukin-4-mediated signaling pathway;GO:2000426|negative regulation of apoptotic cell clearance;GO:2000427|positive regulation of apoptotic cell clearance;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0001618|virus receptor activity;GO:0001786|phosphatidylserine binding;GO:0004888|transmembrane signaling receptor activity;GO:0005136|interleukin-4 receptor binding;GO:0042802|identical protein binding;GO:0097001|ceramide binding;","K20395","CD300B_D_F; CO300B/D/F antigen"]
["ENSRNOG00000061394",43,2.766208842,362,23.3713932,0.118358748,-3.078761752,{"v":9.61464e-64,"d":"9.61E-64"},{"v":3.83197e-63,"d":"3.83E-63"},"down","yes","Clec4e","protein_coding","chr4:156607614-156612767:-","gi|149049512|gb|EDM01966.1|",1161,{"v":2E-159,"d":"2.00E-159"},"macrophage-inducible C-type lectin [Rattus norvegicus]","gi|54312113|ref|NM_001005897.1|",706,0,"Rattus norvegicus C-type lectin domain family 4, member E (Clec4e), mRNA","Q67EQ1",442,{"v":2e-157,"d":"2.00E-157"},"C-type lectin domain family 4 member E",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0001819|positive regulation of cytokine production;GO:0002221|pattern recognition receptor signaling pathway;GO:0002292|T cell differentiation involved in immune response;GO:0006955|immune response;GO:0038094|Fc-gamma receptor signaling pathway;GO:0042742|defense response to bacterium;GO:0045087|innate immune response;GO:0061760|antifungal innate immune response;","GO:0001891|phagocytic cup;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030670|phagocytic vesicle membrane;GO:0042995|cell projection;","GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0030246|carbohydrate binding;GO:0038023|signaling receptor activity;GO:0038187|pattern recognition receptor activity;GO:0051861|glycolipid binding;","K10059","CLEC4E, MINCLE; C-type lectin domain family 4 member E"]
["ENSRNOG00000015895",214,13.76671377,712,45.96804407,0.299484436,-1.739447064,{"v":1.15682E-63,"d":"1.16E-63"},{"v":4.60415e-63,"d":"4.60E-63"},"down","yes","B4galt6","protein_coding","chr18:11958390-12015247:-","gi|13929042|ref|NP_113928.1|",1987,0,"beta-1,4-galactosyltransferase 6 [Rattus norvegicus]","gi|13929041|ref|NM_031740.1|",5589,0,"Rattus norvegicus UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6 (B4galt6), mRNA","O88419",769,0,"Beta-1,4-galactosyltransferase 6",".",".",".",".","pfam13733","Glyco_transf_7N","N-terminal region of glycosyl transferase group 7. This is the N-terminal half of a family of galactosyltransferases from a wide range of Metazoa with three related galactosyltransferases activities, all three of which are possessed by one sequence in some cases. EC:2.4.1.90, N-acetyllactosamine synthase; EC:2.4.1.38, Beta-N-acetylglucosaminyl-glycopeptide beta-1,4- galactosyltransferase; and EC:2.4.1.22 Lactose synthase. Note that N-acetyllactosamine synthase is a component of Lactose synthase along with alpha-lactalbumin, in the absence of alpha-lactalbumin EC:2.4.1.90 is the catalysed reaction.","GO:0001572|lactosylceramide biosynthetic process;GO:0005975|carbohydrate metabolic process;GO:0006486|protein glycosylation;GO:0006688|glycosphingolipid biosynthetic process;GO:0010706|ganglioside biosynthetic process via lactosylceramide;GO:0021955|central nervous system neuron axonogenesis;GO:0022010|central nervous system myelination;GO:0042551|neuron maturation;GO:0070085|glycosylation;","GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;GO:0032580|Golgi cisterna membrane;","GO:0008378|galactosyltransferase activity;GO:0008489|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity;GO:0016757|transferase activity, transferring glycosyl groups;GO:0046872|metal ion binding;","K07553","B4GALT6; beta-1,4-galactosyltransferase 6 [EC:2.4.1.274]"]
["ENSRNOG00000003013",571,36.7326802,1284,82.8974278,0.443110012,-1.174263171,{"v":1.20513e-63,"d":"1.21E-63"},{"v":4.79309e-63,"d":"4.79E-63"},"down","yes","Rpgr","protein_coding","chrX:12566645-12747882:+","gi|392343043|ref|XP_003754780.1|",5001,0,"PREDICTED: X-linked retinitis pigmentosa GTPase regulator isoform X1 [Rattus norvegicus]","gi|672087051|ref|XM_008773079.1|",3208,0,"PREDICTED: Rattus norvegicus retinitis pigmentosa GTPase regulator (Rpgr), transcript variant X1, mRNA","Q9R0X5",1558,0,"X-linked retinitis pigmentosa GTPase regulator","ECU04g1500",82,{"v":3e-15,"d":"3.00E-15"},"COG5184","pfam00415","RCC1","Regulator of chromosome condensation (RCC1) repeat.","GO:0007601|visual perception;GO:0008150|biological_process;GO:0042073|intraciliary transport;GO:0042462|eye photoreceptor cell development;GO:0060042|retina morphogenesis in camera-type eye;GO:0060271|cilium assembly;GO:0071482|cellular response to light stimulus;","GO:0001750|photoreceptor outer segment;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005813|centrosome;GO:0005929|cilium;GO:0032391|photoreceptor connecting cilium;GO:0036064|ciliary basal body;GO:0036126|sperm flagellum;GO:0042995|cell projection;","GO:0003674|molecular_function;","K19607","RPGR; X-linked retinitis pigmentosa GTPase regulator"]
["ENSRNOG00000037814",25,1.608260955,313,20.20786207,0.079585903,-3.651343277,{"v":1.42209e-63,"d":"1.42E-63"},{"v":5.6481e-63,"d":"5.65E-63"},"down","yes","Cxcl17","protein_coding","chr1:80984964-80996726:-","gi|157819233|ref|NP_001100961.1|",626,{"v":3E-79,"d":"3.00E-79"},"VEGF coregulated chemokine 1 precursor [Rattus norvegicus]","gi|157819232|ref|NM_001107491.1|",795,0,"Rattus norvegicus chemokine (C-X-C motif) ligand 17 (Cxcl17), mRNA","Q5UW37",171,{"v":7e-52,"d":"7.00E-52"},"C-X-C motif chemokine 17",".",".",".",".","pfam15211","CXCL17","VEGF co-regulated chemokine 1.","GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0010759|positive regulation of macrophage chemotaxis;GO:0048246|macrophage chemotaxis;GO:0050728|negative regulation of inflammatory response;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0090026|positive regulation of monocyte chemotaxis;","GO:0005615|extracellular space;",".","K22627","CXCL17; C-X-C motif chemokine 17"]
["ENSRNOG00000019854",62,3.988487167,407,26.27667688,0.151788112,-2.719869293,{"v":2.36474e-63,"d":"2.36E-63"},{"v":9.37899e-63,"d":"9.38E-63"},"down","yes","Napsa","protein_coding","chr1:95064900-95077094:+","gi|13928928|ref|NP_113858.1|",2075,0,"napsin-A precursor [Rattus norvegicus]","gi|162135962|ref|NM_031670.2|",1306,0,"Rattus norvegicus napsin A aspartic peptidase (Napsa), mRNA","O09043",722,0,"Napsin-A",".",".",".",".","pfam00026","Asp","Eukaryotic aspartyl protease. Aspartyl (acid) proteases include pepsins, cathepsins, and renins. Two-domain structure, probably arising from ancestral duplication. This family does not include the retroviral nor retrotransposon proteases (pfam00077), which are much smaller and appear to be homologous to a single domain of the eukaryotic asp proteases.","GO:0033619|membrane protein proteolysis;GO:0043129|surfactant homeostasis;","GO:0005615|extracellular space;GO:0005764|lysosome;GO:0097208|alveolar lamellar body;","GO:0004175|endopeptidase activity;GO:0004190|aspartic-type endopeptidase activity;GO:0008233|peptidase activity;","K08565","NAPSA; napsin-A [EC:3.4.23.-]"]
["ENSRNOG00000017897",557,35.83205407,1261,81.41250503,0.44012961,-1.183999662,{"v":2.42868E-63,"d":"2.43E-63"},{"v":9.6259e-63,"d":"9.63E-63"},"down","yes","Adam8","protein_coding","chr1:194770060-194788801:-","gi|564298577|ref|XP_006223620.1|",3584,0,"PREDICTED: disintegrin and metalloproteinase domain-containing protein 8 isoform X3 [Rattus norvegicus]","gi|672014439|ref|XM_006223558.2|",3177,0,"PREDICTED: Rattus norvegicus ADAM metallopeptidase domain 8 (Adam8), transcript variant X3, mRNA","Q05910",1222,0,"Disintegrin and metalloproteinase domain-containing protein 8",".",".",".",".","pfam01421","Reprolysin","Reprolysin (M12B) family zinc metalloprotease. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as human ADAM8 and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.","GO:0000902|cell morphogenesis;GO:0001525|angiogenesis;GO:0002523|leukocyte migration involved in inflammatory response;GO:0002675|positive regulation of acute inflammatory response;GO:0002693|positive regulation of cellular extravasation;GO:0006508|proteolysis;GO:0006954|inflammatory response;GO:0008150|biological_process;GO:0022407|regulation of cell-cell adhesion;GO:0033089|positive regulation of T cell differentiation in thymus;GO:0043406|positive regulation of MAP kinase activity;GO:0043524|negative regulation of neuron apoptotic process;GO:0045089|positive regulation of innate immune response;GO:0045780|positive regulation of bone resorption;GO:0045785|positive regulation of cell adhesion;GO:0048247|lymphocyte chemotaxis;GO:0050729|positive regulation of inflammatory response;GO:0051044|positive regulation of membrane protein ectodomain proteolysis;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051897|positive regulation of protein kinase B signaling;GO:0070245|positive regulation of thymocyte apoptotic process;GO:0071456|cellular response to hypoxia;GO:0098609|cell-cell adhesion;GO:2000309|positive regulation of tumor necrosis factor (ligand) superfamily member 11 production;GO:2000391|positive regulation of neutrophil extravasation;GO:2000406|positive regulation of T cell migration;GO:2000415|positive regulation of fibronectin-dependent thymocyte migration;GO:2000418|positive regulation of eosinophil migration;","GO:0002102|podosome;GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0032010|phagolysosome;GO:0032127|dense core granule membrane;GO:0042581|specific granule;GO:0070820|tertiary granule;GO:0071133|alpha9-beta1 integrin-ADAM8 complex;","GO:0003674|molecular_function;GO:0004222|metalloendopeptidase activity;GO:0005509|calcium ion binding;GO:0008237|metallopeptidase activity;GO:0008270|zinc ion binding;GO:0050839|cell adhesion molecule binding;","K06540","ADAM8, CD156a; disintegrin and metalloproteinase domain-containing protein 8 [EC:3.4.24.-]"]
["ENSRNOG00000005679",108,6.947687324,508,32.7974247,0.211836368,-2.238977804,{"v":2.64513E-63,"d":"2.65E-63"},{"v":1.04693E-62,"d":"1.05E-62"},"down","yes","Fap","protein_coding","chr3:47138813-47225545:-","gi|20301994|ref|NP_620205.1|",4015,0,"seprase [Rattus norvegicus]","gi|20301993|ref|NM_138850.1|",2275,0,"Rattus norvegicus fibroblast activation protein, alpha (Fap), mRNA","P97321",1521,0,"Prolyl endopeptidase FAP","SPACUNK4.08",303,{"v":2e-88,"d":"2.00E-88"},"COG1506","pfam00930","DPPIV_N","Dipeptidyl peptidase IV (DPP IV) N-terminal region. This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.","GO:0006508|proteolysis;GO:0007155|cell adhesion;GO:0010710|regulation of collagen catabolic process;GO:0010716|negative regulation of extracellular matrix disassembly;GO:0043542|endothelial cell migration;GO:0051603|proteolysis involved in cellular protein catabolic process;GO:0051726|regulation of cell cycle;GO:0060244|negative regulation of cell proliferation involved in contact inhibition;GO:0097325|melanocyte proliferation;GO:1900119|positive regulation of execution phase of apoptosis;GO:1902362|melanocyte apoptotic process;GO:1903054|negative regulation of extracellular matrix organization;","GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0030027|lamellipodium;GO:0031258|lamellipodium membrane;GO:0045177|apical part of cell;GO:0045178|basal part of cell;GO:1905368|peptidase complex;","GO:0002020|protease binding;GO:0004175|endopeptidase activity;GO:0004252|serine-type endopeptidase activity;GO:0005178|integrin binding;GO:0008233|peptidase activity;GO:0008236|serine-type peptidase activity;GO:0008239|dipeptidyl-peptidase activity;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;","K08674","FAP; fibroblast activation protein, alpha [EC:3.4.21.-]"]
["ENSRNOG00000011901",23,1.479600078,306,19.75592905,0.074893976,-3.739006506,{"v":3.12357E-63,"d":"3.12E-63"},{"v":1.23458E-62,"d":"1.23E-62"},"down","yes","Rrad","protein_coding","chr19:354198-357417:+","gi|399498561|ref|NP_445790.2|",1313,{"v":1E-176,"d":"1.00E-176"},"GTP-binding protein RAD [Rattus norvegicus]","gi|672083957|ref|XM_006255055.2|",1531,0,"PREDICTED: Rattus norvegicus Ras-related associated with diabetes (Rrad), transcript variant X1, mRNA","O88667",503,{"v":2E-175,"d":"2.00E-175"},"GTP-binding protein RAD",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0030308|negative regulation of cell growth;GO:1901842|negative regulation of high voltage-gated calcium channel activity;","GO:0005575|cellular_component;GO:0005886|plasma membrane;","GO:0003674|molecular_function;GO:0003924|GTPase activity;GO:0005246|calcium channel regulator activity;GO:0005516|calmodulin binding;GO:0005525|GTP binding;","K07845","RRAD, RAD1; Ras-related associated with diabetes"]
["ENSRNOG00000004589",61,3.924156729,404,26.0829913,0.150448876,-2.732654765,{"v":3.34439e-63,"d":"3.34E-63"},{"v":1.32094E-62,"d":"1.32E-62"},"down","yes","Galnt16","protein_coding","chr6:100170306-100250705:+","gi|50510795|dbj|BAD32383.1|",2890,0,"mKIAA1130 protein [Mus musculus]","gi|291167741|ref|NM_001100863.1|",3846,0,"Rattus norvegicus polypeptide N-acetylgalactosaminyltransferase 16 (Galnt16), mRNA","Q9JJ61",1089,0,"Polypeptide N-acetylgalactosaminyltransferase 16",".",".",".",".","pfam00535","Glycos_transf_2","Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.","GO:0018242|protein O-linked glycosylation via serine;GO:0018243|protein O-linked glycosylation via threonine;","GO:0000139|Golgi membrane;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;","GO:0004653|polypeptide N-acetylgalactosaminyltransferase activity;GO:0030246|carbohydrate binding;GO:0046872|metal ion binding;","K00710","GALNT; polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41]"]
["ENSRNOG00000046452",78,5.017774178,443,28.60090383,0.175441105,-2.510941289,{"v":3.45728e-63,"d":"3.46E-63"},{"v":1.36459e-62,"d":"1.36E-62"},"down","yes","Fcgr2b","protein_coding","chr13:83193163-83207778:-","gi|564381693|ref|XP_006250295.1|",1357,{"v":1E-174,"d":"1.00E-174"},"PREDICTED: low affinity immunoglobulin gamma Fc region receptor II-b isoform X1 [Rattus norvegicus]","gi|228480381|gb|AC111734.5|",2522,0,"Rattus norvegicus CH230-184H10 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q63203",456,{"v":1e-149,"d":"1.00E-149"},"Low affinity immunoglobulin gamma Fc region receptor II",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0001811|negative regulation of type I hypersensitivity;GO:0002434|immune complex clearance;GO:0002638|negative regulation of immunoglobulin production;GO:0002862|negative regulation of inflammatory response to antigenic stimulus;GO:0002865|negative regulation of acute inflammatory response to antigenic stimulus;GO:0002924|negative regulation of humoral immune response mediated by circulating immunoglobulin;GO:0006898|receptor-mediated endocytosis;GO:0006911|phagocytosis, engulfment;GO:0006952|defense response;GO:0007166|cell surface receptor signaling pathway;GO:0009617|response to bacterium;GO:0016064|immunoglobulin mediated immune response;GO:0016358|dendrite development;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0021549|cerebellum development;GO:0030889|negative regulation of B cell proliferation;GO:0032355|response to estradiol;GO:0032456|endocytic recycling;GO:0032693|negative regulation of interleukin-10 production;GO:0033030|negative regulation of neutrophil apoptotic process;GO:0038096|Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0046330|positive regulation of JNK cascade;GO:0048169|regulation of long-term neuronal synaptic plasticity;GO:0050765|negative regulation of phagocytosis;GO:0050766|positive regulation of phagocytosis;GO:0050776|regulation of immune response;GO:0050777|negative regulation of immune response;GO:0050859|negative regulation of B cell receptor signaling pathway;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0071219|cellular response to molecule of bacterial origin;GO:0071222|cellular response to lipopolysaccharide;GO:1901216|positive regulation of neuron death;GO:1902950|regulation of dendritic spine maintenance;GO:1904646|cellular response to amyloid-beta;GO:1905898|positive regulation of response to endoplasmic reticulum stress;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0043197|dendritic spine;GO:0044297|cell body;GO:0045121|membrane raft;GO:0055037|recycling endosome;","GO:0001540|amyloid-beta binding;GO:0004888|transmembrane signaling receptor activity;GO:0019772|low-affinity IgG receptor activity;GO:0019864|IgG binding;GO:0019865|immunoglobulin binding;GO:0044877|protein-containing complex binding;","K12560","FCGR2B, CD32; low affinity immunoglobulin gamma Fc receptor II-b"]
["ENSRNOG00000006025",91,5.854069875,470,30.34407404,0.192923003,-2.373902926,{"v":7.59494e-63,"d":"7.59E-63"},{"v":2.98535E-62,"d":"2.99E-62"},"down","yes","Lamb3","protein_coding","chr13:104833873-104875405:+","gi|281371337|ref|NP_001094311.1|",5742,0,"laminin subunit beta-3 precursor [Rattus norvegicus]","gi|281371336|ref|NM_001100841.1|",4078,0,"Rattus norvegicus laminin subunit beta 3 (Lamb3), mRNA","Q61087",2065,0,"Laminin subunit beta-3",".",".",".",".","pfam00055","Laminin_N","Laminin N-terminal (Domain VI).","GO:0008150|biological_process;GO:0009887|animal organ morphogenesis;GO:0009888|tissue development;GO:0016477|cell migration;GO:0034446|substrate adhesion-dependent cell spreading;GO:0035987|endodermal cell differentiation;GO:0050873|brown fat cell differentiation;GO:0070831|basement membrane assembly;","GO:0005575|cellular_component;GO:0005604|basement membrane;GO:0005610|laminin-5 complex;GO:0043256|laminin complex;","GO:0005201|extracellular matrix structural constituent;GO:0044877|protein-containing complex binding;","K06244","LAMB3; laminin, beta 3"]
["ENSRNOG00000007036",662,42.58675008,1411,91.09678397,0.467489062,-1.096995485,{"v":1.00674e-62,"d":"1.01E-62"},{"v":3.95176e-62,"d":"3.95E-62"},"down","yes","Tgfbr1","protein_coding","chr5:61653233-61710777:+","gi|672052531|ref|XP_006238092.2|",2584,0,"PREDICTED: TGF-beta receptor type-1 isoform X1 [Rattus norvegicus]","gi|672052530|ref|XM_006238030.2|",5715,0,"PREDICTED: Rattus norvegicus transforming growth factor, beta receptor 1 (Tgfbr1), transcript variant X1, mRNA","P80204",999,0,"TGF-beta receptor type-1",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0001501|skeletal system development;GO:0001525|angiogenesis;GO:0001666|response to hypoxia;GO:0001701|in utero embryonic development;GO:0001822|kidney development;GO:0001824|blastocyst development;GO:0001837|epithelial to mesenchymal transition;GO:0001937|negative regulation of endothelial cell proliferation;GO:0001938|positive regulation of endothelial cell proliferation;GO:0002088|lens development in camera-type eye;GO:0003222|ventricular trabecula myocardium morphogenesis;GO:0003223|ventricular compact myocardium morphogenesis;GO:0006355|regulation of transcription, DNA-templated;GO:0006468|protein phosphorylation;GO:0006915|apoptotic process;GO:0007165|signal transduction;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0007399|nervous system development;GO:0007507|heart development;GO:0007566|embryo implantation;GO:0007568|aging;GO:0008284|positive regulation of cell proliferation;GO:0008354|germ cell migration;GO:0008584|male gonad development;GO:0009636|response to toxic substance;GO:0009791|post-embryonic development;GO:0009952|anterior/posterior pattern specification;GO:0010468|regulation of gene expression;GO:0010628|positive regulation of gene expression;GO:0010717|regulation of epithelial to mesenchymal transition;GO:0010718|positive regulation of epithelial to mesenchymal transition;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0014070|response to organic cyclic compound;GO:0018105|peptidyl-serine phosphorylation;GO:0018107|peptidyl-threonine phosphorylation;GO:0030199|collagen fibril organization;GO:0030307|positive regulation of cell growth;GO:0030324|lung development;GO:0030335|positive regulation of cell migration;GO:0031100|animal organ regeneration;GO:0031396|regulation of protein ubiquitination;GO:0032331|negative regulation of chondrocyte differentiation;GO:0032924|activin receptor signaling pathway;GO:0034695|response to prostaglandin E;GO:0035556|intracellular signal transduction;GO:0042118|endothelial cell activation;GO:0043065|positive regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0043393|regulation of protein binding;GO:0043410|positive regulation of MAPK cascade;GO:0043542|endothelial cell migration;GO:0043627|response to estrogen;GO:0045602|negative regulation of endothelial cell differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0046777|protein autophosphorylation;GO:0048538|thymus development;GO:0048565|digestive tract development;GO:0048663|neuron fate commitment;GO:0048701|embryonic cranial skeleton morphogenesis;GO:0048705|skeletal system morphogenesis;GO:0048762|mesenchymal cell differentiation;GO:0048844|artery morphogenesis;GO:0048870|cell motility;GO:0051272|positive regulation of cellular component movement;GO:0051491|positive regulation of filopodium assembly;GO:0051496|positive regulation of stress fiber assembly;GO:0051602|response to electrical stimulus;GO:0051897|positive regulation of protein kinase B signaling;GO:0060017|parathyroid gland development;GO:0060021|roof of mouth development;GO:0060037|pharyngeal system development;GO:0060043|regulation of cardiac muscle cell proliferation;GO:0060317|cardiac epithelial to mesenchymal transition;GO:0060389|pathway-restricted SMAD protein phosphorylation;GO:0060391|positive regulation of SMAD protein signal transduction;GO:0060412|ventricular septum morphogenesis;GO:0060978|angiogenesis involved in coronary vascular morphogenesis;GO:0060982|coronary artery morphogenesis;GO:0070723|response to cholesterol;GO:0071363|cellular response to growth factor stimulus;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:1902894|negative regulation of pri-miRNA transcription by RNA polymerase II;GO:1902895|positive regulation of pri-miRNA transcription by RNA polymerase II;GO:1905007|positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation;GO:1905075|positive regulation of tight junction disassembly;GO:1905223|epicardium morphogenesis;GO:2001235|positive regulation of apoptotic signaling pathway;GO:2001237|negative regulation of extrinsic apoptotic signaling pathway;","GO:0005634|nucleus;GO:0005768|endosome;GO:0005886|plasma membrane;GO:0005901|caveola;GO:0005923|bicellular tight junction;GO:0009986|cell surface;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0032991|protein-containing complex;GO:0043235|receptor complex;GO:0045121|membrane raft;GO:0048179|activin receptor complex;","GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0005024|transforming growth factor beta-activated receptor activity;GO:0005025|transforming growth factor beta receptor activity, type I;GO:0005102|signaling receptor binding;GO:0005114|type II transforming growth factor beta receptor binding;GO:0005524|ATP binding;GO:0016361|activin receptor activity, type I;GO:0019838|growth factor binding;GO:0031625|ubiquitin protein ligase binding;GO:0044877|protein-containing complex binding;GO:0046332|SMAD binding;GO:0046872|metal ion binding;GO:0048185|activin binding;GO:0050431|transforming growth factor beta binding;GO:0070411|I-SMAD binding;","K04674","TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]"]
["ENSRNOG00000009385",84,5.403756808,454,29.31108428,0.184358816,-2.439411684,{"v":1.14028e-62,"d":"1.14E-62"},{"v":4.46368e-62,"d":"4.46E-62"},"down","yes","Pik3cg","protein_coding","chr6:48766864-48802043:-","gi|392348758|ref|XP_003750188.1|",5918,0,"PREDICTED: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X2 [Rattus norvegicus]","gi|672055966|ref|XM_006240005.2|",6572,0,"PREDICTED: Rattus norvegicus phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma (Pik3cg), transcript variant X5, mRNA","Q9JHG7",2245,0,"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform","SPAC458.05",227,{"v":3e-60,"d":"3.00E-60"},"COG5032","pfam00613","PI3Ka","Phosphoinositide 3-kinase family, accessory domain (PIK domain). PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation.","GO:0001932|regulation of protein phosphorylation;GO:0002675|positive regulation of acute inflammatory response;GO:0003376|sphingosine-1-phosphate receptor signaling pathway;GO:0006468|protein phosphorylation;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0010595|positive regulation of endothelial cell migration;GO:0010897|negative regulation of triglyceride catabolic process;GO:0014065|phosphatidylinositol 3-kinase signaling;GO:0016310|phosphorylation;GO:0016477|cell migration;GO:0032252|secretory granule localization;GO:0035022|positive regulation of Rac protein signal transduction;GO:0036092|phosphatidylinositol-3-phosphate biosynthetic process;GO:0043085|positive regulation of catalytic activity;GO:0043406|positive regulation of MAP kinase activity;GO:0046854|phosphatidylinositol phosphorylation;GO:0048015|phosphatidylinositol-mediated signaling;GO:0051897|positive regulation of protein kinase B signaling;GO:0071320|cellular response to cAMP;GO:0097284|hepatocyte apoptotic process;GO:1903169|regulation of calcium ion transmembrane transport;GO:2000270|negative regulation of fibroblast apoptotic process;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005942|phosphatidylinositol 3-kinase complex;GO:0005943|phosphatidylinositol 3-kinase complex, class IA;GO:0005944|phosphatidylinositol 3-kinase complex, class IB;GO:0016020|membrane;","GO:0005524|ATP binding;GO:0016301|kinase activity;GO:0016303|1-phosphatidylinositol-3-kinase activity;GO:0035005|1-phosphatidylinositol-4-phosphate 3-kinase activity;GO:0042802|identical protein binding;GO:0046875|ephrin receptor binding;GO:0046934|phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0052742|phosphatidylinositol kinase activity;GO:0052812|phosphatidylinositol-3,4-bisphosphate 5-kinase activity;","K21289","PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [EC:2.7.1.153]"]
["ENSRNOG00000047967",66,4.24580892,413,26.66404804,0.159233471,-2.650784471,{"v":1.44868E-62,"d":"1.45E-62"},{"v":5.65542e-62,"d":"5.66E-62"},"down","yes","Arhgef19","protein_coding","chr5:153536013-153554203:+","gi|157822717|ref|NP_001102162.1|",4179,0,"rho guanine nucleotide exchange factor 19 [Rattus norvegicus]","gi|157822716|ref|NM_001108692.1|",3648,0,"Rattus norvegicus Rho guanine nucleotide exchange factor 19 (Arhgef19), mRNA","Q8BWA8",1387,0,"Rho guanine nucleotide exchange factor 19","SPCC645.07",72.8,{"v":5e-12,"d":"5.00E-12"},"COG5422","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0032956|regulation of actin cytoskeleton organization;GO:0042060|wound healing;GO:0043547|positive regulation of GTPase activity;GO:0090630|activation of GTPase activity;",".","GO:0005085|guanyl-nucleotide exchange factor activity;","K20691","ARHGEF19, WGEF; Rho guanine nucleotide exchange factor 19"]
["ENSRNOG00000003840",175,11.25782668,635,40.99678088,0.274602699,-1.864582289,{"v":1.65949E-62,"d":"1.66E-62"},{"v":6.47396e-62,"d":"6.47E-62"},"down","yes","Slit2","protein_coding","chr14:62617067-62955948:-","gi|60360540|dbj|BAD90514.1|",7747,0,"mKIAA4141 protein [Mus musculus]","gi|268370202|ref|NM_022632.2|",7007,0,"Rattus norvegicus slit guidance ligand 2 (Slit2), mRNA","O94813",2884,0,"Slit homolog 2 protein","alr0124_1",77.4,{"v":2e-13,"d":"2.00E-13"},"COG4886","pfam02210","Laminin_G_2","Laminin G domain. This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.","GO:0001656|metanephros development;GO:0001657|ureteric bud development;GO:0001701|in utero embryonic development;GO:0001822|kidney development;GO:0001933|negative regulation of protein phosphorylation;GO:0002042|cell migration involved in sprouting angiogenesis;GO:0002689|negative regulation of leukocyte chemotaxis;GO:0003180|aortic valve morphogenesis;GO:0003184|pulmonary valve morphogenesis;GO:0007399|nervous system development;GO:0007409|axonogenesis;GO:0007411|axon guidance;GO:0007420|brain development;GO:0008045|motor neuron axon guidance;GO:0008285|negative regulation of cell proliferation;GO:0010593|negative regulation of lamellipodium assembly;GO:0010596|negative regulation of endothelial cell migration;GO:0010629|negative regulation of gene expression;GO:0014912|negative regulation of smooth muscle cell migration;GO:0021510|spinal cord development;GO:0021772|olfactory bulb development;GO:0021836|chemorepulsion involved in postnatal olfactory bulb interneuron migration;GO:0021972|corticospinal neuron axon guidance through spinal cord;GO:0022029|telencephalon cell migration;GO:0030154|cell differentiation;GO:0030308|negative regulation of cell growth;GO:0030336|negative regulation of cell migration;GO:0030517|negative regulation of axon extension;GO:0030837|negative regulation of actin filament polymerization;GO:0031290|retinal ganglion cell axon guidance;GO:0031667|response to nutrient levels;GO:0032870|cellular response to hormone stimulus;GO:0033563|dorsal/ventral axon guidance;GO:0035385|Roundabout signaling pathway;GO:0042699|follicle-stimulating hormone signaling pathway;GO:0043065|positive regulation of apoptotic process;GO:0043086|negative regulation of catalytic activity;GO:0043116|negative regulation of vascular permeability;GO:0048754|branching morphogenesis of an epithelial tube;GO:0048812|neuron projection morphogenesis;GO:0048846|axon extension involved in axon guidance;GO:0050728|negative regulation of inflammatory response;GO:0050919|negative chemotaxis;GO:0050929|induction of negative chemotaxis;GO:0051058|negative regulation of small GTPase mediated signal transduction;GO:0051414|response to cortisol;GO:0060412|ventricular septum morphogenesis;GO:0060603|mammary gland duct morphogenesis;GO:0060763|mammary duct terminal end bud growth;GO:0061364|apoptotic process involved in luteolysis;GO:0070100|negative regulation of chemokine-mediated signaling pathway;GO:0071504|cellular response to heparin;GO:0071672|negative regulation of smooth muscle cell chemotaxis;GO:0071676|negative regulation of mononuclear cell migration;GO:0090024|negative regulation of neutrophil chemotaxis;GO:0090027|negative regulation of monocyte chemotaxis;GO:0090260|negative regulation of retinal ganglion cell axon guidance;GO:0090288|negative regulation of cellular response to growth factor stimulus;GO:0098609|cell-cell adhesion;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0004963|follicle-stimulating hormone receptor activity;GO:0005095|GTPase inhibitor activity;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0008201|heparin binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0043237|laminin-1 binding;GO:0043394|proteoglycan binding;GO:0043395|heparan sulfate proteoglycan binding;GO:0045499|chemorepellent activity;GO:0048495|Roundabout binding;","K06839","SLIT2; slit 2"]
["ENSRNOG00000064648",736,47.3472025,1515,97.81121738,0.484067204,-1.046720742,{"v":2.10636e-62,"d":"2.11E-62"},{"v":8.20607e-62,"d":"8.21E-62"},"down","yes","ENSRNOG00000064648","lncRNA","chr13:106499883-106501619:+",".",".",".",".","gi|49615112|gb|AC118802.7|",1737,0,"Rattus norvegicus 13 BAC CH230-72B9 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSRNOG00000000562",11,0.70763482,268,17.30257839,0.040897651,-4.611838191,{"v":2.74294e-62,"d":"2.74E-62"},{"v":1.06715E-61,"d":"1.07E-61"},"down","yes","Prf1","protein_coding","chr20:29246202-29251701:+","gi|149038739|gb|EDL93028.1|",3110,0,"perforin 1 (pore forming protein), isoform CRA_a [Rattus norvegicus]","gi|59709458|ref|NM_017330.2|",1919,0,"Rattus norvegicus perforin 1 (Prf1), mRNA","P35763",1125,0,"Perforin-1",".",".",".",".","pfam01823","MACPF","MAC/Perforin domain. The membrane-attack complex (MAC) of the complement system forms transmembrane channels. These channels disrupt the phospholipid bilayer of target cells, leading to cell lysis and death. A number of proteins participate in the assembly of the MAC. Freshly activated C5b binds to C6 to form a C5b-6 complex, then to C7 forming the C5b-7 complex. The C5b-7 complex binds to C8, which is composed of three chains (alpha, beta, and gamma), thus forming the C5b-8 complex. C5b-8 subsequently binds to C9 and acts as a catalyst in the polymerization of C9. Active MAC has a subunit composition of C5b-C6-C7-C8-C9{n}. Perforin is a protein found in cytolytic T-cell and killer cells. In the presence of calcium, perforin polymerizes into transmembrane tubules and is capable of lysing, non-specifically, a variety of target cells. There are a number of regions of similarity in the sequences of complement components C6, C7, C8-alpha, C8-beta, C9 and perforin. The X-ray crystal structure of a MACPF domain reveals that it shares a common fold with bacterial cholesterol dependent cytolysins (pfam01289) such as perfringolysin O. Three key pieces of evidence suggests that MACPF domains and CDCs are homologous: Functional similarity (pore formation), conservation of three glycine residues at a hinge in both families and conservation of a complex core fold.","GO:0001771|immunological synapse formation;GO:0001913|T cell mediated cytotoxicity;GO:0002357|defense response to tumor cell;GO:0002418|immune response to tumor cell;GO:0006915|apoptotic process;GO:0007623|circadian rhythm;GO:0019835|cytolysis;GO:0045471|response to ethanol;GO:0051260|protein homooligomerization;GO:0051607|defense response to virus;GO:0051712|positive regulation of killing of cells of other organism;GO:0055085|transmembrane transport;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0031410|cytoplasmic vesicle;GO:0031904|endosome lumen;GO:0044194|cytolytic granule;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;GO:0022829|wide pore channel activity;GO:0042802|identical protein binding;","K07818","PRF1; perforin 1"]
["ENSRNOG00000033064",11,0.70763482,267,17.23801653,0.041050826,-4.606444932,{"v":4.9223e-62,"d":"4.92E-62"},{"v":1.90984E-61,"d":"1.91E-61"},"down","yes","Edil3","protein_coding","chr2:19890373-20405008:+","gi|392338494|ref|XP_003753552.1|",2521,0,"PREDICTED: EGF-like repeat and discoidin I-like domain-containing protein 3 [Rattus norvegicus]","gi|672015252|ref|XM_003753504.3|",4645,0,"PREDICTED: Rattus norvegicus EGF-like repeats and discoidin I-like domains 3 (Edil3), mRNA","O35474",947,0,"EGF-like repeat and discoidin I-like domain-containing protein 3",".",".",".",".","pfam00754","F5_F8_type_C","F5/8 type C domain. This domain is also known as the discoidin (DS) domain family.","GO:0007155|cell adhesion;GO:0010811|positive regulation of cell-substrate adhesion;",".","GO:0005509|calcium ion binding;","K24464","EDIL3; EGF-like repeat and discoidin I-like domain-containing protein 3"]
["ENSRNOG00000037331",35,2.251565336,334,21.56366112,0.104414799,-3.259601895,{"v":5.67469e-62,"d":"5.67E-62"},{"v":2.19877e-61,"d":"2.20E-61"},"down","yes","Cd33","protein_coding","chr1:93930971-93950149:-","gi|149056119|gb|EDM07550.1|",1392,0,"rCG54544 [Rattus norvegicus]","gi|672036639|ref|XM_008759423.1|",1186,0,"PREDICTED: Rattus norvegicus CD33 molecule (Cd33), mRNA","Q63994",429,{"v":2e-144,"d":"2.00E-144"},"Myeloid cell surface antigen CD33",".",".",".",".","pfam10471","APC_CDC26","Anaphase-promoting complex APC subunit 1. The anaphase-promoting complex (APC) or cyclosome is a cell cycle-regulated ubiquitin-protein ligase that regulates important events in mitosis such as the initiation of anaphase and exit from telophase. The APC, in conjunction with other enzymes, assembles multi-ubiquitin chains on a variety of regulatory proteins thereby targeting them for proteolysis by the 26S proteasome. CDC26 is one of the nine or so subunits identified within APC but its exact function is not known. The APC/C becomes active at the metaphase/anaphase transition and remains active during G1 phase. One mechanism linked to activation of the APC/C is phosphorylation. The yeast APC/C is composed of at least 13 subunits, but the function of many of the subunits is unknown. Hcn1 is the smallest subunit of the S. pombe APC/C, and is found to be essential for cell viability, APC/C integrity, and proper APC/C regulation. In addition, Hcn1 phosphorylation indicates a specific role for the phosphorylation of this subunit late in the cell cycle.","GO:0002765|immune response-inhibiting signal transduction;GO:0007155|cell adhesion;GO:0032691|negative regulation of interleukin-1 beta production;GO:0032717|negative regulation of interleukin-8 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0050714|positive regulation of protein secretion;GO:0051926|negative regulation of calcium ion transport;GO:0098609|cell-cell adhesion;GO:1903615|positive regulation of protein tyrosine phosphatase activity;","GO:0005654|nucleoplasm;GO:0005777|peroxisome;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0019903|protein phosphatase binding;GO:0033691|sialic acid binding;","K06473","CD33, SIGLEC3; CD33 antigen"]
["ENSRNOG00000001976",1,0.064330438,291,18.78750116,0.003424108,-8.190055962,{"v":9.80573e-62,"d":"9.81E-62"},{"v":3.78915e-61,"d":"3.79E-61"},"down","yes","Tmprss2","protein_coding","chr11:36934306-36973715:-","gi|149060257|gb|EDM10971.1|",1941,0,"transmembrane protease, serine 2, isoform CRA_b [Rattus norvegicus]","gi|829708433|ref|NM_130424.3|",1831,0,"Rattus norvegicus transmembrane protease, serine 2 (Tmprss2), mRNA","Q9JIQ8",680,0,"Transmembrane protease serine 2","mlr3307",70.5,{"v":7e-12,"d":"7.00E-12"},"COG5640","pfam15494","SRCR_2","Scavenger receptor cysteine-rich domain. SRCR_2 is a scavenger receptor cysteine-rich domain family found largely on vertebrate sequences up-stream of the trypsin-like transmembrane serine protease, Spinesin.","GO:0006508|proteolysis;GO:0006897|endocytosis;GO:0016540|protein autoprocessing;GO:0046598|positive regulation of viral entry into host cell;","GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0004252|serine-type endopeptidase activity;GO:0005044|scavenger receptor activity;","K09633","TMPRSS2; transmembrane protease serine 2 [EC:3.4.21.-]"]
["ENSRNOG00000015591",709,45.61028067,1471,94.97049555,0.480257373,-1.058120333,{"v":1.07602e-61,"d":"1.08E-61"},{"v":4.15235e-61,"d":"4.15E-61"},"down","yes","Cndp2","protein_coding","chr18:78039932-78056922:-","gi|58219062|ref|NP_001010920.1|",2400,0,"cytosolic non-specific dipeptidase [Rattus norvegicus]","gi|672083294|ref|XM_006254999.2|",2103,0,"PREDICTED: Rattus norvegicus CNDP dipeptidase 2 (metallopeptidase M20 family) (Cndp2), transcript variant X2, mRNA","Q6Q0N1",929,0,"Cytosolic non-specific dipeptidase","SPBC1198.08",474,{"v":3e-159,"d":"3.00E-159"},"COG0624","pfam01546","Peptidase_M20","Peptidase family M20/M25/M40. This family includes a range of zinc metallopeptidases belonging to several families in the peptidase classification. Family M20 are Glutamate carboxypeptidases. Peptidase family M25 contains X-His dipeptidases.","GO:0006508|proteolysis;","GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0004180|carboxypeptidase activity;GO:0008233|peptidase activity;GO:0016805|dipeptidase activity;GO:0046872|metal ion binding;GO:0070573|metallodipeptidase activity;GO:0103046|alanylglutamate dipeptidase activity;","K08660","CNDP2; cytosolic nonspecific dipeptidase [EC:3.4.13.18]"]
["ENSRNOG00000027871",57,3.666834977,388,25.05000155,0.146380629,-2.772203447,{"v":1.15401E-61,"d":"1.15E-61"},{"v":4.45029e-61,"d":"4.45E-61"},"down","yes","Rapgefl1","protein_coding","chr10:83793694-83810371:+","gi|672069269|ref|XP_008766424.1|",2817,0,"PREDICTED: rap guanine nucleotide exchange factor-like 1 isoform X2 [Rattus norvegicus]","gi|672069268|ref|XM_008768202.1|",4153,0,"PREDICTED: Rattus norvegicus Rap guanine nucleotide exchange factor (GEF)-like 1 (Rapgefl1), transcript variant X2, mRNA","Q68EF8",1072,0,"Rap guanine nucleotide exchange factor-like 1",".",".",".",".","pfam00617","RasGEF","RasGEF domain. Guanine nucleotide exchange factor for Ras-like small GTPases.",".",".",".",".","."]
["ENSRNOG00000008517",468,30.10664507,1113,71.8573498,0.418977949,-1.255053777,{"v":2.38338e-61,"d":"2.38E-61"},{"v":9.15417e-61,"d":"9.15E-61"},"down","yes","Cdc42ep1","protein_coding","chr7:110395332-110403200:+","gi|119226202|ref|NP_001073168.1|",1085,{"v":2E-136,"d":"2.00E-136"},"cdc42 effector protein 1 [Rattus norvegicus]","gi|119226201|ref|NM_001079700.1|",1762,0,"Rattus norvegicus CDC42 effector protein 1 (Cdc42ep1), mRNA","A1A5P0",417,{"v":5e-136,"d":"5.00E-136"},"Cdc42 effector protein 1",".",".",".",".","pfam00786","PBD","P21-Rho-binding domain. Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).","GO:0007266|Rho protein signal transduction;GO:0008360|regulation of cell shape;GO:0030838|positive regulation of actin filament polymerization;GO:0031274|positive regulation of pseudopodium assembly;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0012505|endomembrane system;",".",".","."]
["ENSRNOG00000021199",166,10.67885274,612,39.51185811,0.270269566,-1.887529031,{"v":2.7812E-61,"d":"2.78E-61"},{"v":1.06678E-60,"d":"1.07E-60"},"down","yes","Fcgr1a","protein_coding","chr2:183851077-183859994:-","gi|158631264|ref|NP_001094306.1|",1822,0,"high affinity immunoglobulin gamma Fc receptor I precursor [Rattus norvegicus]","gi|165971690|gb|BC158809.1|",1249,0,"Rattus norvegicus Fc fragment of IgG, high affinity Ia, receptor (CD64), mRNA (cDNA clone MGC:188236 IMAGE:7364883), complete cds","P26151",615,0,"High affinity immunoglobulin gamma Fc receptor I",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0001788|antibody-dependent cellular cytotoxicity;GO:0001798|positive regulation of type IIa hypersensitivity;GO:0001805|positive regulation of type III hypersensitivity;GO:0006898|receptor-mediated endocytosis;GO:0006910|phagocytosis, recognition;GO:0006911|phagocytosis, engulfment;GO:0007166|cell surface receptor signaling pathway;GO:0009617|response to bacterium;GO:0019884|antigen processing and presentation of exogenous antigen;GO:0032355|response to estradiol;GO:0038094|Fc-gamma receptor signaling pathway;GO:0042590|antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:0042742|defense response to bacterium;GO:0050766|positive regulation of phagocytosis;GO:0050776|regulation of immune response;GO:0060100|positive regulation of phagocytosis, engulfment;GO:0061098|positive regulation of protein tyrosine kinase activity;GO:0071871|response to epinephrine;GO:1904058|positive regulation of sensory perception of pain;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0045121|membrane raft;","GO:0004888|transmembrane signaling receptor activity;GO:0005515|protein binding;GO:0019770|IgG receptor activity;GO:0019864|IgG binding;GO:0031774|leukotriene receptor binding;","K06498","FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I"]
["ENSRNOG00000019440",37,2.380226213,336,21.69278484,0.109724327,-3.188044677,{"v":3.69655e-61,"d":"3.70E-61"},{"v":1.41692e-60,"d":"1.42E-60"},"down","yes","Kcnn4","protein_coding","chr1:79959322-79974340:+","gi|397739060|ref|NP_075410.2|",1884,0,"intermediate conductance calcium-activated potassium channel protein 4 isoform a [Rattus norvegicus]","gi|397739059|ref|NM_023021.2|",1924,0,"Rattus norvegicus potassium calcium-activated channel subfamily N member 4 (Kcnn4), transcript variant 1, mRNA","O89109",709,0,"Intermediate conductance calcium-activated potassium channel protein 4",".",".",".",".","pfam03530","SK_channel","Calcium-activated SK potassium channel.","GO:0002376|immune system process;GO:0006811|ion transport;GO:0006813|potassium ion transport;GO:0006816|calcium ion transport;GO:0006820|anion transport;GO:0006884|cell volume homeostasis;GO:0030322|stabilization of membrane potential;GO:0045332|phospholipid translocation;GO:0046541|saliva secretion;GO:0050714|positive regulation of protein secretion;GO:0050862|positive regulation of T cell receptor signaling pathway;GO:0071805|potassium ion transmembrane transport;GO:0097623|potassium ion export across plasma membrane;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0031982|vesicle;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0045121|membrane raft;","GO:0005267|potassium channel activity;GO:0005516|calmodulin binding;GO:0015269|calcium-activated potassium channel activity;GO:0016286|small conductance calcium-activated potassium channel activity;GO:0019903|protein phosphatase binding;GO:0022894|Intermediate conductance calcium-activated potassium channel activity;","K04945","KCNN4, KCA3.1; potassium intermediate/small conductance calcium-activated channel subfamily N member 4"]
["ENSRNOG00000017020",228,14.66733991,723,46.67822453,0.314222318,-1.670142442,{"v":4.0209e-61,"d":"4.02E-61"},{"v":1.54022e-60,"d":"1.54E-60"},"down","yes","Inpp5d","protein_coding","chr9:88287677-88392746:+","gi|9506813|ref|NP_062184.1|",5734,0,"phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 [Rattus norvegicus]","gi|9506812|ref|NM_019311.1|",4859,0,"Rattus norvegicus inositol polyphosphate-5-phosphatase D (Inpp5d), mRNA","P97573",2197,0,"Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1","YNL106c_2",131,{"v":2e-30,"d":"2.00E-30"},"COG5411","pfam00017","SH2","SH2 domain.","GO:0006915|apoptotic process;GO:0008150|biological_process;GO:0008285|negative regulation of cell proliferation;GO:0008340|determination of adult lifespan;GO:0009968|negative regulation of signal transduction;GO:0016064|immunoglobulin mediated immune response;GO:0030853|negative regulation of granulocyte differentiation;GO:0030889|negative regulation of B cell proliferation;GO:0032715|negative regulation of interleukin-6 production;GO:0035556|intracellular signal transduction;GO:0043065|positive regulation of apoptotic process;GO:0045579|positive regulation of B cell differentiation;GO:0045621|positive regulation of lymphocyte differentiation;GO:0045648|positive regulation of erythrocyte differentiation;GO:0045656|negative regulation of monocyte differentiation;GO:0045659|negative regulation of neutrophil differentiation;GO:0045671|negative regulation of osteoclast differentiation;GO:0045779|negative regulation of bone resorption;GO:0046856|phosphatidylinositol dephosphorylation;GO:0050777|negative regulation of immune response;GO:0050869|negative regulation of B cell activation;","GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0030863|cortical cytoskeleton;GO:0045121|membrane raft;","GO:0004439|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0004445|inositol-polyphosphate 5-phosphatase activity;GO:0005515|protein binding;GO:0016791|phosphatase activity;GO:0017124|SH3 domain binding;GO:0030487|inositol-4,5-bisphosphate 5-phosphatase activity;GO:0034485|phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity;GO:0034594|phosphatidylinositol trisphosphate phosphatase activity;GO:0051425|PTB domain binding;GO:0052658|inositol-1,4,5-trisphosphate 5-phosphatase activity;GO:0052659|inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity;","K03084","SHIP1, INPP5D; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 [EC:3.1.3.86]"]
["ENSRNOG00000000818",765,49.21278521,1546,99.81263503,0.493051658,-1.020189286,{"v":4.31899e-61,"d":"4.32E-61"},{"v":1.65218e-60,"d":"1.65E-60"},"down","yes","Nrm","protein_coding","chr20:2877567-2891802:-","gi|261399902|ref|NP_001119759.2|",2318,0,"phostensin [Rattus norvegicus]","gi|261399901|ref|NM_001126287.2|",2632,0,"Rattus norvegicus protein phosphatase 1, regulatory subunit 18 (Ppp1r18), mRNA","Q8BQ30",797,0,"Phostensin",".",".",".",".","pfam13914","Phostensin","Phostensin PP1-binding and SH3-binding region. Phostensin has been identified as a PP1 regulatory protein binding PP1 at the KISF motif. The domain also appears to carry an incomplete incomplete SH3-binding domain PxRxP further upstream. It is likely that Phostensin targets PP1 to the F-actin cytoskeleton. Phostensin binds to actin and decreases the elongation and depolymerization rates of actin filament pointed ends.",".","GO:0005635|nuclear envelope;GO:0005637|nuclear inner membrane;GO:0016021|integral component of membrane;GO:0031965|nuclear membrane;",".",".","."]
["ENSRNOG00000036833",163,10.48586142,605,39.05992509,0.268455748,-1.897243797,{"v":5.21576E-61,"d":"5.22E-61"},{"v":1.9939e-60,"d":"1.99E-60"},"down","yes","Zfp385a","protein_coding","chr7:134448921-134475548:-","gi|205360912|ref|NP_001128560.1|",1698,0,"zinc finger protein 385A isoform 1 [Rattus norvegicus]","gi|205360911|ref|NM_001135088.1|",2445,0,"Rattus norvegicus zinc finger protein 385A (Zfp385a), transcript variant 1, mRNA","Q8VD12",585,0,"Zinc finger protein 385A",".",".",".",".","pfam12874","zf-met","Zinc-finger of C2H2 type. This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.","GO:0006915|apoptotic process;GO:0006974|cellular response to DNA damage stimulus;GO:0007599|hemostasis;GO:0007611|learning or memory;GO:0007626|locomotory behavior;GO:0008150|biological_process;GO:0008298|intracellular mRNA localization;GO:0010609|mRNA localization resulting in posttranscriptional regulation of gene expression;GO:0030220|platelet formation;GO:0035855|megakaryocyte development;GO:0045600|positive regulation of fat cell differentiation;GO:0070889|platelet alpha granule organization;GO:1902164|positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;GO:1902166|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:2000765|regulation of cytoplasmic translation;","GO:0000785|chromatin;GO:0005575|cellular_component;GO:0005634|nucleus;GO:0030425|dendrite;GO:0043025|neuronal cell body;","GO:0002039|p53 binding;GO:0003674|molecular_function;GO:0003730|mRNA 3'-UTR binding;GO:0008270|zinc ion binding;",".","."]
["ENSRNOG00000006472",136,8.748939593,553,35.70270839,0.245049745,-2.028853448,{"v":6.26689e-61,"d":"6.27E-61"},{"v":2.39252E-60,"d":"2.39E-60"},"down","yes","Hspa2","protein_coding","chr6:95128350-95131287:+","gi|880895163|ref|XP_012970791.1|",3077,0,"PREDICTED: heat shock-related 70 kDa protein 2 [Mesocricetus auratus]","gi|672056767|ref|XM_006240247.2|",2482,0,"PREDICTED: Rattus norvegicus heat shock protein 2 (Hspa2), transcript variant X1, mRNA","P14659",1187,0,"Heat shock-related 70 kDa protein 2",".",".",".",".","pfam00012","HSP70","Hsp70 protein. Hsp70 chaperones help to fold many proteins. Hsp70 assisted folding involves repeated cycles of substrate binding and release. Hsp70 activity is ATP dependent. Hsp70 proteins are made up of two regions: the amino terminus is the ATPase domain and the carboxyl terminus is the substrate binding region.","GO:0001934|positive regulation of protein phosphorylation;GO:0007140|male meiotic nuclear division;GO:0007141|male meiosis I;GO:0007283|spermatogenesis;GO:0007286|spermatid development;GO:0009408|response to heat;GO:0009409|response to cold;GO:0010971|positive regulation of G2/M transition of mitotic cell cycle;GO:0016192|vesicle-mediated transport;GO:0032781|positive regulation of ATPase activity;GO:0034620|cellular response to unfolded protein;GO:0042026|protein refolding;GO:0051085|chaperone cofactor-dependent protein refolding;GO:0070194|synaptonemal complex disassembly;GO:0090084|negative regulation of inclusion body assembly;GO:1901896|positive regulation of calcium-transporting ATPase activity;","GO:0000795|synaptonemal complex;GO:0001673|male germ cell nucleus;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0036128|CatSper complex;GO:0072687|meiotic spindle;","GO:0005515|protein binding;GO:0005524|ATP binding;GO:0016887|ATPase activity;GO:0019899|enzyme binding;GO:0031072|heat shock protein binding;GO:0044183|protein binding involved in protein folding;GO:0048156|tau protein binding;GO:0051082|unfolded protein binding;GO:0051087|chaperone binding;GO:0051787|misfolded protein binding;GO:0051861|glycolipid binding;GO:0097718|disordered domain specific binding;","K03283","HSPA1s; heat shock 70kDa protein 1/2/6/8"]
["ENSRNOG00000050430",74,4.760452426,424,27.37422849,0.173902707,-2.523647708,{"v":6.84107e-61,"d":"6.84E-61"},{"v":2.60998e-60,"d":"2.61E-60"},"down","yes","Vav1","protein_coding","chr9:2157900-2208937:+","gi|162287067|ref|NP_036891.2|",4363,0,"proto-oncogene vav [Rattus norvegicus]","gi|162287066|ref|NM_012759.2|",2822,0,"Rattus norvegicus vav guanine nucleotide exchange factor 1 (Vav1), mRNA","P54100",1679,0,"Proto-oncogene vav",".",".",".",".","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0002768|immune response-regulating cell surface receptor signaling pathway;GO:0006909|phagocytosis;GO:0006955|immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007229|integrin-mediated signaling pathway;GO:0007264|small GTPase mediated signal transduction;GO:0008361|regulation of cell size;GO:0030217|T cell differentiation;GO:0030593|neutrophil chemotaxis;GO:0035556|intracellular signal transduction;GO:0042110|T cell activation;GO:0043087|regulation of GTPase activity;GO:0043547|positive regulation of GTPase activity;GO:0045785|positive regulation of cell adhesion;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;GO:0048468|cell development;GO:0072593|reactive oxygen species metabolic process;","GO:0005911|cell-cell junction;","GO:0001784|phosphotyrosine residue binding;GO:0005085|guanyl-nucleotide exchange factor activity;GO:0046872|metal ion binding;GO:0140031|phosphorylation-dependent protein binding;","K05730","VAV; guanine nucleotide exchange factor VAV"]
["ENSRNOG00000024846",115,7.398000391,510,32.92654842,0.224681928,-2.154044005,{"v":1.16789E-60,"d":"1.17E-60"},{"v":4.43496e-60,"d":"4.43E-60"},"down","yes","Ier5l","protein_coding","chr3:13744078-13745647:-","gi|26329649|dbj|BAC28563.1|",1084,{"v":6e-140,"d":"6.00E-140"},"unnamed protein product [Mus musculus]","gi|49533628|gb|AC115341.6|",1570,0,"Rattus norvegicus 3 BAC CH230-248O1 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam05760","IER","Immediate early response protein (IER). This family consists of several eukaryotic immediate early response (IER) 2 and 5 proteins. The role of IER5 is unclear although it play an important role in mediating the cellular response to mitogenic signals. Again, little is known about the function of IER2 although it is thought to play a role in mediating the cellular responses to a variety of extracellular signals.",".",".",".",".","."]
["ENSRNOG00000029079",39,2.508887089,339,21.88647042,0.114631873,-3.124919864,{"v":1.2972e-60,"d":"1.30E-60"},{"v":4.91948e-60,"d":"4.92E-60"},"down","yes","Hspb7","protein_coding","chr5:153727588-153731266:+","gi|821034534|ref|XP_012353958.1|",794,{"v":2e-97,"d":"2.00E-97"},"PREDICTED: heat shock protein beta-7 isoform X3 [Nomascus leucogenys]","gi|158749560|ref|NM_031607.1|",1737,0,"Rattus norvegicus heat shock protein family B (small) member 7 (Hspb7), mRNA","P35385",274,{"v":2e-86,"d":"2.00E-86"},"Heat shock protein beta-7",".",".",".",".","pfam00011","HSP20","Hsp20/alpha crystallin family.","GO:0007507|heart development;GO:0009408|response to heat;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0015030|Cajal body;GO:0015629|actin cytoskeleton;GO:0016235|aggresome;","GO:0031005|filamin binding;","K09546","HSPB7; heat shock protein beta-7"]
["ENSRNOG00000015411",80,5.146435055,436,28.14897081,0.182828534,-2.451436849,{"v":1.3713e-60,"d":"1.37E-60"},{"v":5.19358e-60,"d":"5.19E-60"},"down","yes","Apobec1","protein_coding","chr4:155800887-155827390:-","gi|148667274|gb|EDK99690.1|",1139,{"v":3e-150,"d":"3.00E-150"},"apolipoprotein B editing complex 1, isoform CRA_b, partial [Mus musculus]","gi|672050786|ref|XM_006237290.2|",898,0,"PREDICTED: Rattus norvegicus apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 (Apobec1), transcript variant X2, mRNA","P38483",473,{"v":1e-163,"d":"1.00E-163"},"C->U-editing enzyme APOBEC-1",".",".",".",".","pfam08210","APOBEC_N","APOBEC-like N-terminal domain. A mechanism of generating protein diversity is mRNA editing. Members of this family are C-to-U editing enzymes. The N-terminal domain of APOBEC-1 like proteins is the catalytic domain, while the C-terminal domain is a pseudocatalyitc domain. More specifically, the catalytic domain is a zinc dependent deaminases domain and is essential for cytidine deamination.APOBEC-3 like members contain two copies of this domain. RNA editing by APOBEC-1 requires homodimerization and this complex interacts with RNA binding proteins to from the editosome (and references therein). This family also includes the functionally homologous activation induced deaminase (AID), which is essential for the development of antibody diversity in B lymphocytes, and the sea lamprey PmCDA1 and PmCDA2, which are predicted to play an AID-like role in the adaptive immune response of jawless vertebrates. Divergent members of this family are present in various eukaryotes such as Nematostella, C. elegans, Micromonas and Emiliania, and prokaryotes such as Wolbachia and Pseudomonas brassicacearum.","GO:0006397|mRNA processing;GO:0006641|triglyceride metabolic process;GO:0006970|response to osmotic stress;GO:0009410|response to xenobiotic stimulus;GO:0009972|cytidine deamination;GO:0010043|response to zinc ion;GO:0010332|response to gamma radiation;GO:0016554|cytidine to uridine editing;GO:0016556|mRNA modification;GO:0032869|cellular response to insulin stimulus;GO:0042127|regulation of cell proliferation;GO:0042157|lipoprotein metabolic process;GO:0042158|lipoprotein biosynthetic process;GO:0042953|lipoprotein transport;GO:0045471|response to ethanol;GO:0046087|cytidine metabolic process;GO:0048255|mRNA stabilization;GO:0050790|regulation of catalytic activity;GO:0051592|response to calcium ion;GO:0051607|defense response to virus;GO:0070383|DNA cytosine deamination;GO:0080111|DNA demethylation;GO:0090209|negative regulation of triglyceride metabolic process;GO:0090310|negative regulation of methylation-dependent chromatin silencing;GO:0090366|positive regulation of mRNA modification;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0003723|RNA binding;GO:0003729|mRNA binding;GO:0004126|cytidine deaminase activity;GO:0004131|cytosine deaminase activity;GO:0005515|protein binding;GO:0008047|enzyme activator activity;GO:0008270|zinc ion binding;GO:0019904|protein domain specific binding;GO:0035925|mRNA 3'-UTR AU-rich region binding;GO:0043021|ribonucleoprotein complex binding;","K16932","APOBEC1; C->U-editing enzyme APOBEC1 [EC:3.5.4.36]"]
["ENSRNOG00000006831",1,0.064330438,284,18.33556814,0.003508505,-8.154927739,{"v":1.67106E-60,"d":"1.67E-60"},{"v":6.32467e-60,"d":"6.32E-60"},"down","yes","Pgr","protein_coding","chr8:6072673-6131344:+","gi|149020703|gb|EDL78508.1|",4239,0,"rCG31710 [Rattus norvegicus]","gi|305419377|gb|HM037361.1|",3399,0,"Rattus norvegicus strain BN progesterone receptor (Pgr) mRNA, complete cds","Q63449",1612,0,"Progesterone receptor",".",".",".",".","pfam02161","Prog_receptor","Progesterone receptor.","GO:0001542|ovulation from ovarian follicle;GO:0001553|luteinization;GO:0002070|epithelial cell maturation;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008284|positive regulation of cell proliferation;GO:0010629|negative regulation of gene expression;GO:0014911|positive regulation of smooth muscle cell migration;GO:0016101|diterpenoid metabolic process;GO:0030518|intracellular steroid hormone receptor signaling pathway;GO:0030879|mammary gland development;GO:0032570|response to progesterone;GO:0038001|paracrine signaling;GO:0042220|response to cocaine;GO:0043066|negative regulation of apoptotic process;GO:0043627|response to estrogen;GO:0044849|estrous cycle;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048286|lung alveolus development;GO:0050678|regulation of epithelial cell proliferation;GO:0050847|progesterone receptor signaling pathway;GO:0060085|smooth muscle relaxation of the bladder outlet;GO:0060180|female mating behavior;GO:0060748|tertiary branching involved in mammary gland duct morphogenesis;GO:0071371|cellular response to gonadotropin stimulus;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0071373|cellular response to luteinizing hormone stimulus;GO:1904709|negative regulation of granulosa cell apoptotic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0043005|neuron projection;GO:0043197|dendritic spine;GO:0043204|perikaryon;GO:0043679|axon terminus;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001223|transcription coactivator binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003707|steroid hormone receptor activity;GO:0004879|nuclear receptor activity;GO:0005102|signaling receptor binding;GO:0005496|steroid binding;GO:0005515|protein binding;GO:0008270|zinc ion binding;GO:0019899|enzyme binding;GO:0042562|hormone binding;GO:0042802|identical protein binding;GO:0043565|sequence-specific DNA binding;GO:0051117|ATPase binding;","K08556","PGR, NR3C3; progesterone receptor"]
["ENSRNOG00000029938",265,17.04756612,783,50.55193611,0.337228748,-1.568200567,{"v":1.76734E-60,"d":"1.77E-60"},{"v":6.68464e-60,"d":"6.68E-60"},"down","yes","Pik3c2b","protein_coding","chr13:44495050-44555612:+","gi|564380471|ref|XP_006249816.1|",8353,0,"PREDICTED: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X1 [Rattus norvegicus]","gi|672073683|ref|XM_006249754.2|",6427,0,"PREDICTED: Rattus norvegicus phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta (Pik3c2b), transcript variant X1, mRNA","O00750",2967,0,"Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta","SPAC458.05",212,{"v":3e-55,"d":"3.00E-55"},"COG5032","pfam00454","PI3_PI4_kinase","Phosphatidylinositol 3- and 4-kinase. Some members of this family probably do not have lipid kinase activity and are protein kinases.","GO:0009267|cellular response to starvation;GO:0014065|phosphatidylinositol 3-kinase signaling;GO:0016236|macroautophagy;GO:0016477|cell migration;GO:0036092|phosphatidylinositol-3-phosphate biosynthetic process;GO:0043491|protein kinase B signaling;GO:0046834|lipid phosphorylation;GO:0046854|phosphatidylinositol phosphorylation;GO:0048015|phosphatidylinositol-mediated signaling;GO:1905037|autophagosome organization;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005942|phosphatidylinositol 3-kinase complex;GO:0016020|membrane;GO:0030139|endocytic vesicle;GO:0043231|intracellular membrane-bounded organelle;","GO:0001727|lipid kinase activity;GO:0005524|ATP binding;GO:0016303|1-phosphatidylinositol-3-kinase activity;GO:0035005|1-phosphatidylinositol-4-phosphate 3-kinase activity;GO:0035091|phosphatidylinositol binding;GO:0052742|phosphatidylinositol kinase activity;","K00923","PIK3C2; phosphatidylinositol-4-phosphate 3-kinase [EC:2.7.1.154]"]
["ENSRNOG00000033581",163,10.48586142,602,38.86623951,0.269793568,-1.890072142,{"v":2.04037E-60,"d":"2.04E-60"},{"v":7.70714e-60,"d":"7.71E-60"},"down","yes","AABR07044388.2","protein_coding","chr20:4026463-4085578:-","gi|569002189|ref|XP_006525251.1|",16840,0,"PREDICTED: tenascin-X isoform X8 [Mus musculus]","gi|755568721|ref|XM_006525456.2|",7433,0,"PREDICTED: Mus musculus tenascin XB (Tnxb), transcript variant X12, mRNA","P22105",3195,0,"Tenascin-X",".",".",".",".","pfam00147","Fibrinogen_C","Fibrinogen beta and gamma chains, C-terminal globular domain.",".",".",".",".","."]
["ENSRNOG00000018285",21,1.350939202,289,18.65837744,0.072403895,-3.787788879,{"v":2.40179E-60,"d":"2.40E-60"},{"v":9.06036e-60,"d":"9.06E-60"},"down","yes","Kcna2","protein_coding","chr2:194704639-194718400:+","gi|25742772|ref|NP_037102.1|",2344,0,"potassium voltage-gated channel subfamily A member 2 [Rattus norvegicus]","gi|672043687|ref|XM_006233132.2|",11833,0,"PREDICTED: Rattus norvegicus potassium voltage-gated channel, shaker-related subfamily, member 2 (Kcna2), transcript variant X1, mRNA","P63142",907,0,"Potassium voltage-gated channel subfamily A member 2","DR0830",67.4,{"v":1E-10,"d":"1.00E-10"},"COG1226","pfam02214","BTB_2","BTB/POZ domain. In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.","GO:0014059|regulation of dopamine secretion;GO:0019228|neuronal action potential;GO:0019233|sensory perception of pain;GO:0021633|optic nerve structural organization;GO:0034765|regulation of ion transmembrane transport;GO:0045188|regulation of circadian sleep/wake cycle, non-REM sleep;GO:0051260|protein homooligomerization;GO:0071805|potassium ion transmembrane transport;GO:0097623|potassium ion export across plasma membrane;","GO:0005768|endosome;GO:0005789|endoplasmic reticulum membrane;GO:0005887|integral component of plasma membrane;GO:0008076|voltage-gated potassium channel complex;GO:0016021|integral component of membrane;GO:0030027|lamellipodium;GO:0030424|axon;GO:0030425|dendrite;GO:0031258|lamellipodium membrane;GO:0032809|neuronal cell body membrane;GO:0033010|paranodal junction;GO:0034705|potassium channel complex;GO:0043204|perikaryon;GO:0043679|axon terminus;GO:0044224|juxtaparanode region of axon;GO:0044305|calyx of Held;GO:0099056|integral component of presynaptic membrane;","GO:0005249|voltage-gated potassium channel activity;GO:0005251|delayed rectifier potassium channel activity;GO:0005515|protein binding;GO:0015271|outward rectifier potassium channel activity;GO:0019894|kinesin binding;","K04875","KCNA2, KV1.2; potassium voltage-gated channel Shaker-related subfamily A member 2"]
["ENSRNOG00000058775",6,0.385982629,248,16.01134119,0.024106827,-5.374414429,{"v":3.66865E-60,"d":"3.67E-60"},{"v":1.37938E-59,"d":"1.38E-59"},"down","yes","Ly49s7","protein_coding","chr4:164761855-164779735:-","gi|57222316|ref|NP_001009494.1|",1336,0,"Ly49 stimulatory receptor 7 [Rattus norvegicus]","gi|57222315|ref|NM_001009494.1|",1054,0,"Rattus norvegicus Ly49 stimulatory receptor 7 (Ly49s7), mRNA","Q60652",300,{"v":1e-98,"d":"1.00E-98"},"Killer cell lectin-like receptor 5",".",".",".",".","pfam08391","Ly49","Ly49-like protein, N-terminal region. The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000001427",85,5.468087246,445,28.73002755,0.190326558,-2.393451209,{"v":3.69231e-60,"d":"3.69E-60"},{"v":1.38736e-59,"d":"1.39E-59"},"down","yes","Orai2","protein_coding","chr12:20497317-20520428:+","gi|281371452|ref|NP_001163874.1|",1564,0,"protein orai-2 [Rattus norvegicus]","gi|281371451|ref|NM_001170403.1|",4047,0,"Rattus norvegicus ORAI calcium release-activated calcium modulator 2 (Orai2), mRNA","Q8BH10",515,{"v":6e-166,"d":"6.00E-166"},"Protein orai-2",".",".",".",".","pfam07856","Orai-1","Mediator of CRAC channel activity. ORAI-1 is a protein homologue of Drosophila Orai and human Orai1, Orai2 and Orai3. ORAI-1 GFP reporters are co- expressed with STIM-1 (ER CA(2+) sensors) in the gonad and intestine. The protein has four predicted transmembrane domains with a highly conserved region between TM2 ad TM3. This conserved domain is thought to function in channel regulation. ORAI1- related proteins are required for the production of the calcium channel, CRAC, along with STIM1-related proteins.","GO:0002115|store-operated calcium entry;GO:0008150|biological_process;GO:0070588|calcium ion transmembrane transport;","GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030426|growth cone;","GO:0003674|molecular_function;GO:0015279|store-operated calcium channel activity;","K16057","ORAI2; calcium release-activated calcium channel protein 2"]
["ENSRNOG00000004226",426,27.40476667,1040,67.14433404,0.408147122,-1.292838812,{"v":4.46555e-60,"d":"4.47E-60"},{"v":1.6757E-59,"d":"1.68E-59"},"down","yes","Irak3","protein_coding","chr7:55653962-55713121:-","gi|157821803|ref|NP_001101571.1|",3284,0,"interleukin-1 receptor-associated kinase 3 [Rattus norvegicus]","gi|187469591|gb|BC166731.1|",3034,0,"Rattus norvegicus interleukin-1 receptor-associated kinase 3, mRNA (cDNA clone MGC:188449 IMAGE:7934689), complete cds","Q8K4B2",1146,0,"Interleukin-1 receptor-associated kinase 3","Cgl2127_1",75.9,{"v":2e-13,"d":"2.00E-13"},"COG0515","pfam00069","Pkinase","Protein kinase domain.","GO:0001819|positive regulation of cytokine production;GO:0002224|toll-like receptor signaling pathway;GO:0002755|MyD88-dependent toll-like receptor signaling pathway;GO:0006468|protein phosphorylation;GO:0008150|biological_process;GO:0009615|response to virus;GO:0010933|positive regulation of macrophage tolerance induction;GO:0010936|negative regulation of macrophage cytokine production;GO:0019221|cytokine-mediated signaling pathway;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0032494|response to peptidoglycan;GO:0032496|response to lipopolysaccharide;GO:0032695|negative regulation of interleukin-12 production;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0034122|negative regulation of toll-like receptor signaling pathway;GO:0035556|intracellular signal transduction;GO:0042177|negative regulation of protein catabolic process;GO:0043242|negative regulation of protein complex disassembly;GO:0043244|regulation of protein complex disassembly;GO:0043330|response to exogenous dsRNA;GO:0043407|negative regulation of MAP kinase activity;GO:0045824|negative regulation of innate immune response;GO:0046777|protein autophosphorylation;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0070498|interleukin-1-mediated signaling pathway;GO:0070555|response to interleukin-1;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;","GO:0000287|magnesium ion binding;GO:0003674|molecular_function;GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;GO:0019901|protein kinase binding;GO:0042803|protein homodimerization activity;GO:0046982|protein heterodimerization activity;","K04732","IRAK3; interleukin-1 receptor-associated kinase 3 [EC:2.7.11.1]"]
["ENSRNOG00000005378",20,1.286608764,284,18.33556814,0.070170106,-3.832999644,{"v":8.4633e-60,"d":"8.46E-60"},{"v":3.16339e-59,"d":"3.16E-59"},"down","yes","Gna15","protein_coding","chr7:8184861-8205508:+","gi|149034406|gb|EDL89143.1|",1864,0,"guanine nucleotide binding protein, alpha 15 [Rattus norvegicus]","gi|672057901|ref|XM_006241021.2|",1799,0,"PREDICTED: Rattus norvegicus guanine nucleotide binding protein, alpha 15 (Gna15), transcript variant X1, mRNA","O88302",721,0,"Guanine nucleotide-binding protein subunit alpha-15",".",".",".",".","pfam00503","G-alpha","G-protein alpha subunit. G proteins couple receptors of extracellular signals to intracellular signaling pathways. The G protein alpha subunit binds guanyl nucleotide and is a weak GTPase. A set of residues that are unique to G-alpha as compared to its ancestor the Arf-like family form a ring of residues centered on the nucleotide binding site. A Ggamma is found fused to an inactive Galpha in the Dictyostelium protein gbqA.","GO:0001508|action potential;GO:0007188|adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0051482|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway;GO:0060158|phospholipase C-activating dopamine receptor signaling pathway;","GO:0005834|heterotrimeric G-protein complex;GO:0016020|membrane;","GO:0001664|G protein-coupled receptor binding;GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0019001|guanyl nucleotide binding;GO:0031683|G-protein beta/gamma-subunit complex binding;GO:0046872|metal ion binding;","K04637","GNA15; guanine nucleotide-binding protein subunit alpha-15"]
["ENSRNOG00000031232",560,36.02504538,1240,80.05670597,0.4499941,-1.152022008,{"v":9.88089e-60,"d":"9.88E-60"},{"v":3.69083e-59,"d":"3.69E-59"},"down","yes","Nrp2","protein_coding","chr9:64123132-64237958:+","gi|672065269|ref|XP_008765359.1|",4880,0,"PREDICTED: neuropilin-2 isoform X2 [Rattus norvegicus]","gi|672065268|ref|XM_008767137.1|",3980,0,"PREDICTED: Rattus norvegicus neuropilin 2 (Nrp2), transcript variant X2, mRNA","O35276",1864,0,"Neuropilin-2",".",".",".",".","pfam00629","MAM","MAM domain. An extracellular domain found in many receptors.","GO:0001525|angiogenesis;GO:0001755|neural crest cell migration;GO:0001764|neuron migration;GO:0003148|outflow tract septum morphogenesis;GO:0007411|axon guidance;GO:0007507|heart development;GO:0021612|facial nerve structural organization;GO:0021649|vestibulocochlear nerve structural organization;GO:0021675|nerve development;GO:0021828|gonadotrophin-releasing hormone neuronal migration to the hypothalamus;GO:0036486|ventral trunk neural crest cell migration;GO:0038084|vascular endothelial growth factor signaling pathway;GO:0048846|axon extension involved in axon guidance;GO:0050919|negative chemotaxis;GO:0061549|sympathetic ganglion development;GO:0061551|trigeminal ganglion development;GO:0097374|sensory neuron axon guidance;GO:0097490|sympathetic neuron projection extension;GO:0097491|sympathetic neuron projection guidance;GO:0099175|regulation of postsynapse organization;GO:1901166|neural crest cell migration involved in autonomic nervous system development;GO:1902285|semaphorin-plexin signaling pathway involved in neuron projection guidance;GO:1903375|facioacoustic ganglion development;GO:1904835|dorsal root ganglion morphogenesis;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0030424|axon;GO:0098978|glutamatergic synapse;GO:0099055|integral component of postsynaptic membrane;","GO:0005021|vascular endothelial growth factor-activated receptor activity;GO:0008201|heparin binding;GO:0017154|semaphorin receptor activity;GO:0042802|identical protein binding;GO:0046872|metal ion binding;","K06819","NRP2; neuropilin 2"]
["ENSRNOG00000057701",27,1.736921831,302,19.49768162,0.089083506,-3.488697857,{"v":2.28222E-59,"d":"2.28E-59"},{"v":8.51369e-59,"d":"8.51E-59"},"down","yes","Myom1","protein_coding","chr9:110915943-111039344:+","gi|300797519|ref|NP_001178513.1|",8872,0,"myomesin-1 [Rattus norvegicus]","gi|300797518|ref|NM_001191584.1|",5551,0,"Rattus norvegicus myomesin 1 (Myom1), mRNA","Q62234",3165,0,"Myomesin-1",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0002074|extraocular skeletal muscle development;GO:0006936|muscle contraction;GO:0010628|positive regulation of gene expression;GO:0010737|protein kinase A signaling;GO:0050714|positive regulation of protein secretion;","GO:0030017|sarcomere;GO:0031430|M band;","GO:0019900|kinase binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0051015|actin filament binding;","K24495","MYOM; myomesin"]
["ENSRNOG00000009760",677,43.55170665,1407,90.83853654,0.479440866,-1.060575209,{"v":2.62826e-59,"d":"2.63E-59"},{"v":9.79819e-59,"d":"9.80E-59"},"down","yes","Palm","protein_coding","chr7:9886643-9912555:-","gi|18677765|ref|NP_570842.1|",1817,0,"paralemmin-1 [Rattus norvegicus]","gi|47938963|gb|BC072525.1|",2504,0,"Rattus norvegicus paralemmin, mRNA (cDNA clone MGC:91516 IMAGE:7097177), complete cds","Q920Q0",704,0,"Paralemmin-1",".",".",".",".","pfam03285","Paralemmin","Paralemmin.","GO:0007010|cytoskeleton organization;GO:0007193|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007194|negative regulation of adenylate cyclase activity;GO:0008104|protein localization;GO:0008360|regulation of cell shape;GO:0051491|positive regulation of filopodium assembly;GO:0060074|synapse maturation;GO:0060160|negative regulation of dopamine receptor signaling pathway;GO:0060999|positive regulation of dendritic spine development;GO:0071257|cellular response to electrical stimulus;GO:0072659|protein localization to plasma membrane;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0009898|cytoplasmic side of plasma membrane;GO:0014069|postsynaptic density;GO:0016323|basolateral plasma membrane;GO:0016327|apicolateral plasma membrane;GO:0030175|filopodium;GO:0030424|axon;GO:0031527|filopodium membrane;GO:0032590|dendrite membrane;GO:0032591|dendritic spine membrane;GO:0044309|neuron spine;","GO:0031750|D3 dopamine receptor binding;","K16519","AKAP2; A-kinase anchor protein 2"]
["ENSRNOG00000069246",434,27.91941017,1047,67.59626706,0.413031834,-1.275675114,{"v":2.91015e-59,"d":"2.91E-59"},{"v":1.08279e-58,"d":"1.08E-58"},"down","yes","Abcg3l3","protein_coding","chr14:4844218-4892194:+","gi|157821469|ref|NP_001100675.1|",3109,0,"ATP-binding cassette, sub-family G (WHITE), member 3 family member [Rattus norvegicus]","gi|672075696|ref|XM_006250606.2|",3504,0,"PREDICTED: Rattus norvegicus ATP-binding cassette, subfamily G (WHITE), member 3-like 3 (Abcg3l3), transcript variant X1, mRNA","Q99P81",970,0,"ATP-binding cassette sub-family G member 3","YCR011c_2",147,{"v":9e-38,"d":"9.00E-38"},"COG1131","pfam01061","ABC2_membrane","ABC-2 type transporter.",".",".",".",".","."]
["ENSRNOG00000026644",234,15.05332254,723,46.67822453,0.322491326,-1.632667737,{"v":3.12413E-59,"d":"3.12E-59"},{"v":1.16089e-58,"d":"1.16E-58"},"down","yes","Glipr1","protein_coding","chr7:47487345-47498429:-","gi|58865542|ref|NP_001011987.1|",1240,{"v":7e-169,"d":"7.00E-169"},"glioma pathogenesis-related protein 1 precursor [Rattus norvegicus]","gi|298881279|emb|FQ229810.1|",1036,0,"Rattus norvegicus TL0ADA46YJ18 mRNA sequence","Q9CWG1",377,{"v":5e-129,"d":"5.00E-129"},"Glioma pathogenesis-related protein 1","YJL079c",64.7,{"v":6E-11,"d":"6.00E-11"},"COG2340","pfam00188","CAP","Cysteine-rich secretory protein family. This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organisms, including prokaryotes and non-vertebrate eukaryotes, The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumor suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilisation. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The Ca++-chelating function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how helothermine from Heloderma horridum horridum blocks the Ca++ transporting ryanodine receptors.",".","GO:0005615|extracellular space;GO:0016021|integral component of membrane;",".","K24834","GLIPR1; glioma pathogenesis-related protein 1"]
["ENSRNOG00000017084",154,9.90688748,579,37.38131674,0.265022432,-1.915813617,{"v":3.28971e-59,"d":"3.29E-59"},{"v":1.22162e-58,"d":"1.22E-58"},"down","yes","Hsd11b2","protein_coding","chr19:33397656-33402899:+","gi|8393573|ref|NP_058777.1|",1800,0,"corticosteroid 11-beta-dehydrogenase isozyme 2 [Rattus norvegicus]","gi|402746764|ref|NM_017081.2|",1848,0,"Rattus norvegicus hydroxysteroid 11-beta dehydrogenase 2 (Hsd11b2), mRNA","P50233",697,0,"Corticosteroid 11-beta-dehydrogenase isozyme 2",".",".",".",".","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.","GO:0001666|response to hypoxia;GO:0002017|regulation of blood volume by renal aldosterone;GO:0007565|female pregnancy;GO:0008211|glucocorticoid metabolic process;GO:0009410|response to xenobiotic stimulus;GO:0032094|response to food;GO:0032868|response to insulin;GO:0048545|response to steroid hormone;GO:0051384|response to glucocorticoid;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005811|lipid droplet;GO:0043231|intracellular membrane-bounded organelle;","GO:0005496|steroid binding;GO:0016491|oxidoreductase activity;GO:0051287|NAD binding;","K00071","HSD11B2; corticosteroid 11-beta-dehydrogenase isozyme 2 [EC:1.1.1.-]"]
["ENSRNOG00000015366",34,2.187234898,320,20.65979509,0.105869148,-3.239645873,{"v":3.83233e-59,"d":"3.83E-59"},{"v":1.4222E-58,"d":"1.42E-58"},"down","yes","Neurl3","protein_coding","chr9:38494489-38502649:-","gi|62078933|ref|NP_001014122.1|",1346,0,"E3 ubiquitin-protein ligase NEURL3 [Rattus norvegicus]","gi|298891378|emb|FQ227363.1|",1424,0,"Rattus norvegicus TL0AEA13YJ20 mRNA sequence","Q5M870",523,0,"E3 ubiquitin-protein ligase NEURL3",".",".",".",".","pfam07177","Neuralized","Neuralized. This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.","GO:0016567|protein ubiquitination;",".","GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;","K15689","NEURL3, LINCR; E3 ubiquitin-protein ligase NEURL3 [EC:2.3.2.27]"]
["ENSRNOG00000019270",89,5.725408998,449,28.98827499,0.197507751,-2.340018823,{"v":3.89098e-59,"d":"3.89E-59"},{"v":1.44209E-58,"d":"1.44E-58"},"down","yes","P2ry6","protein_coding","chr1:155295111-155330808:-","gi|16923974|ref|NP_476465.1|",1481,0,"P2Y purinoceptor 6 [Rattus norvegicus]","gi|48675856|ref|NM_057124.2|",2465,0,"Rattus norvegicus pyrimidinergic receptor P2Y6 (P2ry6), mRNA","Q63371",575,0,"P2Y purinoceptor 6",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0006909|phagocytosis;GO:0007186|G protein-coupled receptor signaling pathway;GO:0014911|positive regulation of smooth muscle cell migration;GO:0030321|transepithelial chloride transport;GO:0031587|positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity;GO:0032962|positive regulation of inositol trisphosphate biosynthetic process;GO:0035589|G protein-coupled purinergic nucleotide receptor signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071380|cellular response to prostaglandin E stimulus;GO:0071407|cellular response to organic cyclic compound;GO:0071415|cellular response to purine-containing compound;GO:1904707|positive regulation of vascular smooth muscle cell proliferation;GO:1905835|cellular response to pyrimidine ribonucleotide;","GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;","GO:0001621|ADP receptor activity;GO:0045029|UDP-activated nucleotide receptor activity;GO:0045030|UTP-activated nucleotide receptor activity;","K04272","P2RY6; P2Y purinoceptor 6"]
["ENSRNOG00000009401",483,31.07160164,1120,72.30928281,0.429704188,-1.218584257,{"v":5.1887e-59,"d":"5.19E-59"},{"v":1.92181E-58,"d":"1.92E-58"},"down","yes","Lmo2","protein_coding","chr3:90365883-90377953:+","gi|215272415|ref|NP_032531.2|",963,{"v":2E-121,"d":"2.00E-121"},"rhombotin-2 isoform 1 [Mus musculus]","gi|348605105|ref|NM_001244781.1|",1398,0,"Rattus norvegicus LIM domain only 2 (Lmo2), transcript variant 4, mRNA","P25801",323,{"v":7e-104,"d":"7.00E-104"},"Rhombotin-2",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.","GO:0008150|biological_process;GO:0035162|embryonic hemopoiesis;GO:0045647|negative regulation of erythrocyte differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0097067|cellular response to thyroid hormone stimulus;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005667|transcription factor complex;GO:0032991|protein-containing complex;","GO:0001221|transcription cofactor binding;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003713|transcription coactivator activity;GO:0042802|identical protein binding;GO:0043425|bHLH transcription factor binding;GO:0046872|metal ion binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;","K15612","LMO2; rhombotin-2"]
["ENSRNOG00000005667",50,3.216521909,360,23.24226948,0.138391043,-2.853177526,{"v":5.21503e-59,"d":"5.22E-59"},{"v":1.93031E-58,"d":"1.93E-58"},"down","yes","Astn1","protein_coding","chr13:70537703-70855440:+","gi|149058301|gb|EDM09458.1|",6670,0,"rCG46046 [Rattus norvegicus]","gi|282158056|ref|NM_001170603.1|",7132,0,"Rattus norvegicus astrotactin 1 (Astn1), mRNA","Q61137",2539,0,"Astrotactin-1",".",".",".",".","pfam14670","FXa_inhibition","Coagulation Factor Xa inhibitory site. This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.","GO:0001764|neuron migration;GO:0007158|neuron cell-cell adhesion;GO:0007626|locomotory behavior;GO:0016477|cell migration;GO:0098609|cell-cell adhesion;","GO:0005768|endosome;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;",".","K24479","ASTN; astrotactin"]
["ENSRNOG00000031930",111,7.140678639,493,31.82899681,0.224345074,-2.156208589,{"v":9.05769e-59,"d":"9.06E-59"},{"v":3.34181E-58,"d":"3.34E-58"},"down","yes","Bin2","protein_coding","chr7:131742002-131786285:-","gi|444515345|gb|ELV10844.1|",2327,0,"Bridging integrator 2 [Tupaia chinensis]","gi|58866017|ref|NM_001012223.1|",1801,0,"Rattus norvegicus bridging integrator 2 (Bin2), mRNA","Q68FR2",597,0,"Bridging integrator 2","VC1649",81.6,{"v":3e-15,"d":"3.00E-15"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006911|phagocytosis, engulfment;GO:0060326|cell chemotaxis;GO:0071800|podosome assembly;GO:0097320|plasma membrane tubulation;","GO:0001891|phagocytic cup;GO:0002102|podosome;GO:0005886|plasma membrane;GO:0005938|cell cortex;GO:0030054|cell junction;GO:0042995|cell projection;","GO:0005543|phospholipid binding;","K20119","BIN2; bridging integrator 2"]
["ENSRNOG00000007443",259,16.66158349,763,49.26069892,0.338232787,-1.563911579,{"v":9.40336e-59,"d":"9.40E-59"},{"v":3.46264e-58,"d":"3.46E-58"},"down","yes","Jag1","protein_coding","chr3:124406794-124442209:-","gi|149023415|gb|EDL80309.1|",6329,0,"jagged 1 [Rattus norvegicus]","gi|9506824|ref|NM_019147.1|",5465,0,"Rattus norvegicus jagged 1 (Jag1), mRNA","Q63722",2436,0,"Protein jagged-1",".",".",".",".","pfam07657","MNNL","N terminus of Notch ligand. This entry represents a region of conserved sequence at the N terminus of several Notch ligand proteins.","GO:0001709|cell fate determination;GO:0001953|negative regulation of cell-matrix adhesion;GO:0001974|blood vessel remodeling;GO:0002011|morphogenesis of an epithelial sheet;GO:0002456|T cell mediated immunity;GO:0003184|pulmonary valve morphogenesis;GO:0003215|cardiac right ventricle morphogenesis;GO:0007219|Notch signaling pathway;GO:0009887|animal organ morphogenesis;GO:0010628|positive regulation of gene expression;GO:0022408|negative regulation of cell-cell adhesion;GO:0030336|negative regulation of cell migration;GO:0031100|animal organ regeneration;GO:0032495|response to muramyl dipeptide;GO:0035909|aorta morphogenesis;GO:0042060|wound healing;GO:0042127|regulation of cell proliferation;GO:0042491|inner ear auditory receptor cell differentiation;GO:0043010|camera-type eye development;GO:0045596|negative regulation of cell differentiation;GO:0045599|negative regulation of fat cell differentiation;GO:0045602|negative regulation of endothelial cell differentiation;GO:0045639|positive regulation of myeloid cell differentiation;GO:0045665|negative regulation of neuron differentiation;GO:0045669|positive regulation of osteoblast differentiation;GO:0045747|positive regulation of Notch signaling pathway;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048839|inner ear development;GO:0060411|cardiac septum morphogenesis;GO:0061073|ciliary body morphogenesis;GO:0061156|pulmonary artery morphogenesis;GO:0061309|cardiac neural crest cell development involved in outflow tract morphogenesis;GO:0061314|Notch signaling involved in heart development;GO:0061444|endocardial cushion cell development;GO:0062043|positive regulation of cardiac epithelial to mesenchymal transition;GO:0072006|nephron development;GO:0072015|glomerular visceral epithelial cell development;GO:0072017|distal tubule development;GO:0072070|loop of Henle development;GO:0097150|neuronal stem cell population maintenance;GO:2000737|negative regulation of stem cell differentiation;","GO:0005886|plasma membrane;GO:0005912|adherens junction;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0045177|apical part of cell;","GO:0005112|Notch binding;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0005543|phospholipid binding;GO:0048018|receptor ligand activity;","K06052","JAG1, CD339; jagged-1"]
["ENSRNOG00000006526",701,45.09563717,1437,92.77539232,0.486073258,-1.040754332,{"v":9.50909e-59,"d":"9.51E-59"},{"v":3.49932e-58,"d":"3.50E-58"},"down","yes","Sema3c","protein_coding","chr4:17583212-17746534:-","gi|672048612|ref|XP_008760867.1|",4135,0,"PREDICTED: semaphorin-3C isoform X1 [Rattus norvegicus]","gi|672048611|ref|XM_008762645.1|",2514,0,"PREDICTED: Rattus norvegicus sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C (Sema3c), transcript variant X1, mRNA","Q62181",1565,0,"Semaphorin-3C",".",".",".",".","pfam01403","Sema","Sema domain. The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and human plexin A-3.","GO:0001755|neural crest cell migration;GO:0001756|somitogenesis;GO:0001974|blood vessel remodeling;GO:0003148|outflow tract septum morphogenesis;GO:0003151|outflow tract morphogenesis;GO:0003215|cardiac right ventricle morphogenesis;GO:0003350|pulmonary myocardium development;GO:0007411|axon guidance;GO:0007507|heart development;GO:0009791|post-embryonic development;GO:0021915|neural tube development;GO:0030335|positive regulation of cell migration;GO:0048843|negative regulation of axon extension involved in axon guidance;GO:0050919|negative chemotaxis;GO:0060174|limb bud formation;GO:0060666|dichotomous subdivision of terminal units involved in salivary gland branching;GO:0071526|semaphorin-plexin signaling pathway;GO:0140074|cardiac endothelial to mesenchymal transition;GO:1905312|positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis;","GO:0005615|extracellular space;GO:0005887|integral component of plasma membrane;","GO:0030215|semaphorin receptor binding;GO:0045499|chemorepellent activity;","K06840","SEMA3; semaphorin 3"]
["ENSRNOG00000016980",7,0.450313067,244,15.75309376,0.028585691,-5.128563035,{"v":9.72812e-59,"d":"9.73E-59"},{"v":3.57761e-58,"d":"3.58E-58"},"down","yes","Qprt","protein_coding","chr1:181718190-181733486:-","gi|564330955|ref|XP_006230308.1|",1744,0,"PREDICTED: nicotinate-nucleotide pyrophosphorylase [carboxylating] isoform X1 [Rattus norvegicus]","gi|672038422|ref|XM_006230246.2|",1361,0,"PREDICTED: Rattus norvegicus quinolinate phosphoribosyltransferase (Qprt), transcript variant X1, mRNA","Q5I0M2",533,0,"Nicotinate-nucleotide pyrophosphorylase [carboxylating]","YFR047c",247,{"v":6e-76,"d":"6.00E-76"},"COG0157","pfam01729","QRPTase_C","Quinolinate phosphoribosyl transferase, C-terminal domain. Quinolinate phosphoribosyl transferase (QPRTase) or nicotinate-nucleotide pyrophosphorylase EC:2.4.2.19 is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to give rise to nicotinic acid mononucleotide (NaMN), pyrophosphate and carbon dioxide. The QA substrate is bound between the C-terminal domain of one subunit, and the N-terminal domain of the other. The C-terminal domain has a 7 beta-stranded TIM barrel-like fold.","GO:0009435|NAD biosynthetic process;GO:0034213|quinolinate catabolic process;GO:0046874|quinolinate metabolic process;","GO:0005737|cytoplasm;GO:1902494|catalytic complex;","GO:0004514|nicotinate-nucleotide diphosphorylase (carboxylating) activity;GO:0042802|identical protein binding;","K00767","nadC, QPRT; nicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:2.4.2.19]"]
["ENSRNOG00000056001",3,0.192991315,243,15.6885319,0.012301426,-6.345030622,{"v":9.74141e-59,"d":"9.74E-59"},{"v":3.58019E-58,"d":"3.58E-58"},"down","yes","Sftpd","protein_coding","chr16:17046483-17059927:-","gi|643358557|gb|AIA98493.1|",872,{"v":2e-110,"d":"2.00E-110"},"pulmonary surfactant protein D [Sigmodon hispidus]","gi|672079518|ref|XM_008771065.1|",1244,0,"PREDICTED: Rattus norvegicus surfactant protein D (Sftpd), transcript variant X1, mRNA","P35248",330,{"v":1E-107,"d":"1.00E-107"},"Pulmonary surfactant-associated protein D",".",".",".",".","pfam09006","Surfac_D-trimer","Lung surfactant protein D coiled-coil trimerization. This domain, predominantly found in lung surfactant protein D, forms a triple-helical parallel coiled coil, and mediates trimerization of the protein.","GO:0007585|respiratory gaseous exchange;GO:0008228|opsonization;GO:0031960|response to corticosteroid;GO:0032703|negative regulation of interleukin-2 production;GO:0042130|negative regulation of T cell proliferation;GO:0043129|surfactant homeostasis;GO:0043152|induction of bacterial agglutination;GO:0045087|innate immune response;GO:0048286|lung alveolus development;GO:0050765|negative regulation of phagocytosis;GO:0050766|positive regulation of phagocytosis;GO:0050828|regulation of liquid surface tension;GO:0051384|response to glucocorticoid;GO:0052403|negative regulation by host of symbiont catalytic activity;GO:0055093|response to hyperoxia;GO:0070848|response to growth factor;GO:1905226|regulation of adhesion of symbiont to host epithelial cell;","GO:0005581|collagen trimer;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005771|multivesicular body;GO:0005791|rough endoplasmic reticulum;GO:0031410|cytoplasmic vesicle;","GO:0001530|lipopolysaccharide binding;GO:0030246|carbohydrate binding;GO:0042802|identical protein binding;GO:0048029|monosaccharide binding;","K10068","SFTPD, SFTP4; pulmonary surfactant-associated protein D"]
["ENSRNOG00000015599",23,1.479600078,288,18.59381558,0.07957485,-3.651543665,{"v":1.20907e-58,"d":"1.21E-58"},{"v":4.43792e-58,"d":"4.44E-58"},"down","yes","Mall","protein_coding","chr3:114927897-114950785:-","gi|62079089|ref|NP_001014204.1|",713,{"v":1E-87,"d":"1.00E-87"},"MAL-like protein [Rattus norvegicus]","gi|62079088|ref|NM_001014182.1|",1778,0,"Rattus norvegicus mal, T-cell differentiation protein-like (Mall), mRNA","Q91X49",262,{"v":2e-82,"d":"2.00E-82"},"MAL-like protein",".",".",".",".","pfam01284","MARVEL","Membrane-associating domain. MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.","GO:0042552|myelination;","GO:0000139|Golgi membrane;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030136|clathrin-coated vesicle;GO:0031410|cytoplasmic vesicle;GO:0045121|membrane raft;","GO:0019911|structural constituent of myelin sheath;",".","."]
["ENSRNOG00000012053",549,35.31741056,1215,78.44265948,0.450232192,-1.151258879,{"v":1.66949e-58,"d":"1.67E-58"},{"v":6.11607e-58,"d":"6.12E-58"},"down","yes","S100a16","protein_coding","chr2:176016268-176022117:+","gi|157818995|ref|NP_001102027.1|",520,{"v":1E-61,"d":"1.00E-61"},"protein S100-A16 [Rattus norvegicus]","gi|298911941|emb|FQ229313.1|",1018,0,"Rattus norvegicus TL0ADA48YF19 mRNA sequence","Q9D708",198,{"v":8e-61,"d":"8.00E-61"},"Protein S100-A16",".",".",".",".","pfam01023","S_100","S-100/ICaBP type calcium binding domain. The S-100 domain is a subfamily of the EF-hand calcium binding proteins.","GO:0051592|response to calcium ion;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0005509|calcium ion binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0048306|calcium-dependent protein binding;","K23768","S100A16, S100F; protein S100-A16"]
["ENSRNOG00000011947",36,2.315895775,322,20.78891881,0.111400492,-3.166172496,{"v":2.46006e-58,"d":"2.46E-58"},{"v":8.98348E-58,"d":"8.98E-58"},"down","yes","Tifab","protein_coding","chr17:8431635-8436592:+","gi|68163499|ref|NP_001020200.1|",767,{"v":2E-92,"d":"2.00E-92"},"TRAF-interacting protein with FHA domain-containing protein B [Rattus norvegicus]","gi|672080896|ref|XM_008771443.1|",2890,0,"PREDICTED: Rattus norvegicus TRAF-interacting protein with forkhead-associated domain, family member B (Tifab), transcript variant X1, mRNA","Q5BK67",300,{"v":6e-94,"d":"6.00E-94"},"TRAF-interacting protein with FHA domain-containing protein B",".",".",".",".","pfam00498","FHA","FHA domain. The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.","GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0007356|thorax and anterior abdomen determination;GO:0021559|trigeminal nerve development;GO:0021650|vestibulocochlear nerve formation;GO:0030432|peristalsis;GO:0031223|auditory behavior;GO:0035112|genitalia morphogenesis;GO:0042472|inner ear morphogenesis;GO:0048634|regulation of muscle organ development;GO:0048806|genitalia development;GO:0048839|inner ear development;GO:0050885|neuromuscular process controlling balance;GO:0071626|mastication;GO:0090102|cochlea development;GO:0090103|cochlea morphogenesis;GO:0097094|craniofacial suture morphogenesis;GO:0098583|learned vocalization behavior;GO:1901078|negative regulation of relaxation of muscle;GO:1905747|negative regulation of saliva secretion;GO:1905748|hard palate morphogenesis;",".",".","K23835","TIFB; TRAF-interacting protein with FHA domain-containing protein B"]
["ENSRNOG00000004660",566,36.41102801,1238,79.92758225,0.455550224,-1.134317976,{"v":3.21083e-58,"d":"3.21E-58"},{"v":1.17101E-57,"d":"1.17E-57"},"down","yes","Fzd6","protein_coding","chr7:70055068-70086776:+","gi|194474080|ref|NP_001124008.1|",3539,0,"frizzled-6 precursor [Rattus norvegicus]","gi|194474079|ref|NM_001130536.1|",4202,0,"Rattus norvegicus frizzled class receptor 6 (Fzd6), mRNA","Q61089",1220,0,"Frizzled-6",".",".",".",".","pfam01534","Frizzled","Frizzled/Smoothened family membrane region. This family contains the membrane spanning region of frizzled and smoothened receptors. This membrane region is predicted to contain seven transmembrane alpha helices. Proteins related to Drosophila frizzled are receptors for Wnt (mediating the beta-catenin signalling pathway), but also the planar cell polarity (PCP) pathway and the Wnt/calcium pathway. The predominantly alpha-helical Cys-rich ligand-binding region (CRD) of Frizzled is both necessary and sufficient for Wnt binding. The smoothened receptor mediates hedgehog signalling.","GO:0001736|establishment of planar polarity;GO:0001843|neural tube closure;GO:0001942|hair follicle development;GO:0008150|biological_process;GO:0030168|platelet activation;GO:0030901|midbrain development;GO:0033278|cell proliferation in midbrain;GO:0035567|non-canonical Wnt signaling pathway;GO:0035880|embryonic nail plate morphogenesis;GO:0042472|inner ear morphogenesis;GO:0043433|negative regulation of DNA-binding transcription factor activity;GO:0048105|establishment of body hair planar orientation;GO:0060070|canonical Wnt signaling pathway;GO:0060071|Wnt signaling pathway, planar cell polarity pathway;GO:0090090|negative regulation of canonical Wnt signaling pathway;","GO:0005575|cellular_component;GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0016327|apicolateral plasma membrane;GO:0030659|cytoplasmic vesicle membrane;GO:0045177|apical part of cell;","GO:0003674|molecular_function;GO:0017147|Wnt-protein binding;GO:0031625|ubiquitin protein ligase binding;GO:0042813|Wnt-activated receptor activity;","K02376","FZD6; frizzled 6"]
["ENSRNOG00000052688",6,0.385982629,240,15.49484632,0.024910388,-5.327108714,{"v":3.30449e-58,"d":"3.30E-58"},{"v":1.2044E-57,"d":"1.20E-57"},"down","yes","Dnah2","protein_coding","chr10:54142737-54267298:-","gi|564312886|ref|XP_006220764.1|",23749,0,"PREDICTED: dynein heavy chain 2, axonemal isoform X1 [Rattus norvegicus]","gi|672024889|ref|XM_006220702.2|",13753,0,"PREDICTED: Rattus norvegicus dynein, axonemal, heavy chain 2 (Dnah2), transcript variant X1, mRNA","P0C6F1",8536,0,"Dynein heavy chain 2, axonemal","YKR054c",821,0,"COG5245","pfam03028","Dynein_heavy","Dynein heavy chain and region D6 of dynein motor. This family represents the C-terminal region of dynein heavy chain. The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained.","GO:0060285|cilium-dependent cell motility;","GO:0005858|axonemal dynein complex;GO:0005874|microtubule;GO:0005930|axoneme;GO:0030286|dynein complex;GO:0031514|motile cilium;GO:0036126|sperm flagellum;","GO:0005524|ATP binding;","K10408","DNAH; dynein axonemal heavy chain"]
["ENSRNOG00000050469",751,48.31215908,1503,97.03647506,0.497876278,-1.006140816,{"v":3.85846e-58,"d":"3.86E-58"},{"v":1.40541e-57,"d":"1.41E-57"},"down","yes","Gng11","protein_coding","chr4:32023003-32028442:+","gi|4758448|ref|NP_004117.1|",366,{"v":1e-38,"d":"1.00E-38"},"guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 precursor [Homo sapiens]","gi|67514558|ref|NM_022396.2|",1802,0,"Rattus norvegicus guanine nucleotide binding protein (G protein), gamma 11 (Gng11), mRNA","P61954",145,{"v":3e-40,"d":"3.00E-40"},"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11",".",".",".",".","pfam00631","G-gamma","GGL domain. G-protein gamma like domains (GGL) are found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling (RGS) proteins. It is also found fused to an inactive Galpha in the Dictyostelium protein gbqA. G-gamma likely shares a common origin with the helical N-terminal unit of G-beta. All organisms that posses a G-beta possess a G-gamma.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005834|heterotrimeric G-protein complex;","GO:0003674|molecular_function;GO:0031681|G-protein beta-subunit binding;","K04546","GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11"]
["ENSRNOG00000010650",193,12.41577457,644,41.57783762,0.298615207,-1.74364046,{"v":6.03663e-58,"d":"6.04E-58"},{"v":2.19459E-57,"d":"2.19E-57"},"down","yes","Plekhh1","protein_coding","chr6:97839288-97888709:+","gi|256818763|ref|NP_001101506.2|",6636,0,"pleckstrin homology domain-containing family H member 1 precursor [Rattus norvegicus]","gi|256818762|ref|NM_001108036.2|",5947,0,"Rattus norvegicus pleckstrin homology, MyTH4 and FERM domain containing H1 (Plekhh1), mRNA","Q80TI1",2419,0,"Pleckstrin homology domain-containing family H member 1",".",".",".",".","pfam00784","MyTH4","MyTH4 domain. Domain in myosin and kinesin tails, present twice in myosin-VIIa, and also present in 3 other myosins.",".","GO:0005856|cytoskeleton;",".","K24020","PLEKHH; pleckstrin homology domain-containing family H"]
["ENSRNOG00000037247",541,34.80276706,1199,77.40966973,0.449591985,-1.153311779,{"v":6.4471e-58,"d":"6.45E-58"},{"v":2.34233E-57,"d":"2.34E-57"},"down","yes","Rras","protein_coding","chr1:95500566-95504357:+","gi|157824216|ref|NP_001101951.1|",961,{"v":1E-127,"d":"1.00E-127"},"ras-related protein R-Ras [Rattus norvegicus]","gi|298882776|emb|FQ211166.1|",955,0,"Rattus norvegicus TL0ABA16YF04 mRNA sequence","D3Z8L7",374,{"v":4e-129,"d":"4.00E-129"},"Ras-related protein R-Ras","SPAC17H9.09c",213,{"v":2E-66,"d":"2.00E-66"},"COG1100","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0002521|leukocyte differentiation;GO:0007265|Ras protein signal transduction;GO:0010595|positive regulation of endothelial cell migration;GO:0030336|negative regulation of cell migration;GO:0045766|positive regulation of angiogenesis;GO:0051896|regulation of protein kinase B signaling;GO:0060325|face morphogenesis;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:1904906|positive regulation of endothelial cell-matrix adhesion via fibronectin;GO:2001214|positive regulation of vasculogenesis;","GO:0005886|plasma membrane;","GO:0003924|GTPase activity;GO:0005515|protein binding;GO:0005525|GTP binding;GO:0019003|GDP binding;GO:0044877|protein-containing complex binding;","K07829","RRAS; Ras-related protein R-Ras"]
["ENSRNOG00000020991",63,4.052817606,386,24.92087783,0.162627402,-2.620357733,{"v":6.91324e-58,"d":"6.91E-58"},{"v":2.50849e-57,"d":"2.51E-57"},"down","yes","Ms4a6a","protein_coding","chr1:208401466-208414758:-","gi|672014692|ref|XP_001075502.5|",1073,{"v":2E-137,"d":"2.00E-137"},"PREDICTED: membrane-spanning 4-domains subfamily A member 6D [Rattus norvegicus]","gi|672014691|ref|XM_001075502.5|",2442,0,"PREDICTED: Rattus norvegicus membrane-spanning 4-domains, subfamily A, member 6A (Ms4a6a), mRNA","Q99N07",316,{"v":9e-100,"d":"9.00E-100"},"Membrane-spanning 4-domains subfamily A member 6D",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.",".","GO:0005802|trans-Golgi network;GO:0016021|integral component of membrane;",".","K22191","MS4A5_6_7; membrane-spanning 4-domains subfamily A member 5/6/7"]
["ENSRNOG00000005109",15,0.964956573,262,16.91520723,0.057046689,-4.131713025,{"v":7.40483e-58,"d":"7.40E-58"},{"v":2.68516e-57,"d":"2.69E-57"},"down","yes","Rprm","protein_coding","chr3:38539581-38540998:-","gi|112984092|ref|NP_001037741.1|",562,{"v":3e-67,"d":"3.00E-67"},"protein reprimo [Rattus norvegicus]","gi|672045340|ref|XM_008761775.1|",1418,0,"PREDICTED: Rattus norvegicus reprimo, TP53 dependent G2 arrest mediator candidate (Rprm), transcript variant X1, mRNA","Q5BJN9",221,{"v":1e-68,"d":"1.00E-68"},"Protein reprimo",".",".",".",".","pfam12737","Mating_C","C-terminal domain of homeodomain 1. Mating in fungi is controlled by the loci that determine the mating type of an individual, and only individuals with differing mating types can mate. Basidiomycete fungi have evolved a unique mating system, termed tetrapolar or bifactorial incompatibility, in which mating type is determined by two unlinked loci; compatibility at both loci is required for mating to occur. The multi-allelic tetrapolar mating system is considered to be a novel innovation that could have only evolved once, and is thus unique to the mushroom fungi. This domain is C-terminal to the homeodomain transcription factor region.","GO:0007346|regulation of mitotic cell cycle;GO:0051726|regulation of cell cycle;","GO:0005737|cytoplasm;GO:0016021|integral component of membrane;",".","K10128","RPRM; reprimo, TP53-dependent G2 arrest mediator candidate"]
["ENSRNOG00000007529",362,23.28761862,925,59.71972018,0.389948556,-1.358644288,{"v":9.40488e-58,"d":"9.40E-58"},{"v":3.4061e-57,"d":"3.41E-57"},"down","yes","Bmf","protein_coding","chr3:105499538-105520145:-","gi|564342296|ref|XP_006234785.1|",1336,{"v":1E-168,"d":"1.00E-168"},"PREDICTED: bcl-2-modifying factor isoform X2 [Rattus norvegicus]","gi|672046480|ref|XM_006234723.2|",4660,0,"PREDICTED: Rattus norvegicus Bcl2 modifying factor (Bmf), transcript variant X2, mRNA","Q8K589",374,{"v":3e-118,"d":"3.00E-118"},"Bcl-2-modifying factor",".",".",".",".","pfam15185","BMF","Bcl-2-modifying factor, apoptosis. BMF is thought to play a role in inducing apoptosis. It is thought to bind to Bcl-2 proteins. This family of proteins is found in eukaryotes. Proteins in this family are typically between 75 and 190 amino acids in length. There are two conserved sequence motifs: GNA and DQF.","GO:0008150|biological_process;GO:0009267|cellular response to starvation;GO:0010507|negative regulation of autophagy;GO:0031334|positive regulation of protein complex assembly;GO:0034644|cellular response to UV;GO:0043065|positive regulation of apoptotic process;GO:0043276|anoikis;GO:0090200|positive regulation of release of cytochrome c from mitochondria;GO:1904093|negative regulation of autophagic cell death;GO:2001234|negative regulation of apoptotic signaling pathway;GO:2001235|positive regulation of apoptotic signaling pathway;","GO:0001669|acrosomal vesicle;GO:0005737|cytoplasm;GO:0015629|actin cytoskeleton;GO:0016459|myosin complex;","GO:0003674|molecular_function;","K17460","BMF; Bcl-2-modifying factor"]
["ENSRNOG00000005141",422,27.14744491,1018,65.72397313,0.413052401,-1.275603277,{"v":1.14813e-57,"d":"1.15E-57"},{"v":4.15547e-57,"d":"4.16E-57"},"down","yes","Hus1","protein_coding","chr14:83688708-83703442:-","gi|157819027|ref|NP_001102562.1|",1445,0,"checkpoint protein HUS1 [Rattus norvegicus]","gi|157819026|ref|NM_001109092.1|",4469,0,"Rattus norvegicus HUS1 checkpoint clamp component (Hus1), mRNA","Q8BQY8",511,{"v":1E-167,"d":"1.00E-167"},"Checkpoint protein HUS1",".",".",".",".","pfam04005","Hus1","Hus1-like protein. Hus1, Rad1, and Rad9 are three evolutionarily conserved proteins required for checkpoint control in fission yeast. These proteins are known to form a stable complex in vivo. Hus1-Rad1-Rad9 complex may form a PCNA-like ring structure, and could function as a sliding clamp during checkpoint control.","GO:0000077|DNA damage checkpoint;GO:0000723|telomere maintenance;GO:0000724|double-strand break repair via homologous recombination;GO:0001932|regulation of protein phosphorylation;GO:0006289|nucleotide-excision repair;GO:0006468|protein phosphorylation;GO:0006974|cellular response to DNA damage stimulus;GO:0009411|response to UV;GO:0009792|embryo development ending in birth or egg hatching;GO:0031573|intra-S DNA damage checkpoint;GO:0033314|mitotic DNA replication checkpoint;GO:0044778|meiotic DNA integrity checkpoint;GO:0071479|cellular response to ionizing radiation;","GO:0005634|nucleus;GO:0005730|nucleolus;GO:0030896|checkpoint clamp complex;GO:0035861|site of double-strand break;",".","K10903","HUS1; HUS1 checkpoint protein"]
["ENSRNOG00000020388",581,37.37598459,1254,80.96057201,0.461656627,-1.115107899,{"v":2.12576e-57,"d":"2.13E-57"},{"v":7.67438e-57,"d":"7.67E-57"},"down","yes","Inpp5f","protein_coding","chr1:183190480-183270276:+","gi|198442866|ref|NP_001101024.2|",5755,0,"phosphatidylinositide phosphatase SAC2 [Rattus norvegicus]","gi|157817146|ref|NM_001107554.1|",4788,0,"Rattus norvegicus inositol polyphosphate-5-phosphatase F (Inpp5f), mRNA","Q8CDA1",2091,0,"Phosphatidylinositide phosphatase SAC2","YKL212w",281,{"v":9e-80,"d":"9.00E-80"},"COG5329","pfam02383","Syja_N","SacI homology domain. This Pfam family represents a protein domain which shows homology to the yeast protein SacI. The SacI homology domain is most notably found at the amino terminal of the inositol 5'-phosphatase synaptojanin.","GO:0001921|positive regulation of receptor recycling;GO:0008150|biological_process;GO:0008344|adult locomotory behavior;GO:0014898|cardiac muscle hypertrophy in response to stress;GO:0031161|phosphatidylinositol catabolic process;GO:0033137|negative regulation of peptidyl-serine phosphorylation;GO:0042532|negative regulation of tyrosine phosphorylation of STAT protein;GO:0046627|negative regulation of insulin receptor signaling pathway;GO:0046856|phosphatidylinositol dephosphorylation;GO:0048015|phosphatidylinositol-mediated signaling;GO:0048681|negative regulation of axon regeneration;GO:0051896|regulation of protein kinase B signaling;GO:0051898|negative regulation of protein kinase B signaling;GO:0072583|clathrin-dependent endocytosis;GO:2000145|regulation of cell motility;GO:2001135|regulation of endocytic recycling;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005769|early endosome;GO:0005905|clathrin-coated pit;GO:0030424|axon;GO:0030425|dendrite;GO:0043025|neuronal cell body;GO:0043231|intracellular membrane-bounded organelle;GO:0045334|clathrin-coated endocytic vesicle;GO:0055037|recycling endosome;","GO:0003674|molecular_function;GO:0034595|phosphatidylinositol phosphate 5-phosphatase activity;GO:0034596|phosphatidylinositol phosphate 4-phosphatase activity;GO:0042803|protein homodimerization activity;GO:0043812|phosphatidylinositol-4-phosphate phosphatase activity;GO:0052833|inositol monophosphate 4-phosphatase activity;","K21798","SAC2, INPP5F; phosphatidylinositol 4-phosphatase [EC:3.1.3.-]"]
["ENSRNOG00000011800",265,17.04756612,765,49.38982264,0.345163542,-1.534648007,{"v":2.39913e-57,"d":"2.40E-57"},{"v":8.65036e-57,"d":"8.65E-57"},"down","yes","F3","protein_coding","chr2:209826959-209838668:+","gi|52138595|ref|NP_037189.2|",1320,{"v":2e-172,"d":"2.00E-172"},"tissue factor precursor [Rattus norvegicus]","gi|52138594|ref|NM_013057.2|",1393,0,"Rattus norvegicus coagulation factor III, tissue factor (F3), mRNA","P42533",508,{"v":3e-172,"d":"3.00E-172"},"Tissue factor",".",".",".",".","pfam09294","Interfer-bind","Interferon-alpha/beta receptor, fibronectin type III. Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.","GO:0001938|positive regulation of endothelial cell proliferation;GO:0002541|activation of plasma proteins involved in acute inflammatory response;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007568|aging;GO:0007596|blood coagulation;GO:0009266|response to temperature stimulus;GO:0009611|response to wounding;GO:0009612|response to mechanical stimulus;GO:0010628|positive regulation of gene expression;GO:0010641|positive regulation of platelet-derived growth factor receptor signaling pathway;GO:0014911|positive regulation of smooth muscle cell migration;GO:0016485|protein processing;GO:0019221|cytokine-mediated signaling pathway;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0032757|positive regulation of interleukin-8 production;GO:0034405|response to fluid shear stress;GO:0045766|positive regulation of angiogenesis;GO:0051897|positive regulation of protein kinase B signaling;GO:0070301|cellular response to hydrogen peroxide;GO:0071404|cellular response to low-density lipoprotein particle stimulus;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0062023|collagen-containing extracellular matrix;GO:1905286|serine-type peptidase complex;","GO:0002020|protease binding;GO:0004252|serine-type endopeptidase activity;GO:0004896|cytokine receptor activity;GO:0005543|phospholipid binding;","K03901","F3, CD142; coagulation factor III (tissue factor)"]
["ENSRNOG00000014504",663,42.65108052,1372,88.57887145,0.481503995,-1.054380325,{"v":2.4195e-57,"d":"2.42E-57"},{"v":8.7183e-57,"d":"8.72E-57"},"down","yes","Il1r1","protein_coding","chr9:42504735-42579937:+","gi|148747433|ref|NP_037255.3|",3033,0,"interleukin-1 receptor type 1 [Rattus norvegicus]","gi|672064797|ref|XM_006244748.2|",3886,0,"PREDICTED: Rattus norvegicus interleukin 1 receptor, type I (Il1r1), transcript variant X3, mRNA","Q02955",1164,0,"Interleukin-1 receptor type 1",".",".",".",".","pfam01582","TIR","TIR domain. The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.","GO:0006954|inflammatory response;GO:0009314|response to radiation;GO:0010286|heat acclimation;GO:0019221|cytokine-mediated signaling pathway;GO:0030728|ovulation;GO:0032729|positive regulation of interferon-gamma production;GO:0050727|regulation of inflammatory response;GO:0070498|interleukin-1-mediated signaling pathway;GO:0070555|response to interleukin-1;GO:0070849|response to epidermal growth factor;GO:0071333|cellular response to glucose stimulus;GO:0071559|response to transforming growth factor beta;GO:0071731|response to nitric oxide;GO:1990834|response to odorant;GO:2000391|positive regulation of neutrophil extravasation;GO:2000556|positive regulation of T-helper 1 cell cytokine production;GO:2000661|positive regulation of interleukin-1-mediated signaling pathway;GO:2001224|positive regulation of neuron migration;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0032991|protein-containing complex;","GO:0002020|protease binding;GO:0003953|NAD+ nucleosidase activity;GO:0004908|interleukin-1 receptor activity;GO:0004909|interleukin-1, type I, activating receptor activity;GO:0005161|platelet-derived growth factor receptor binding;GO:0005515|protein binding;GO:0019966|interleukin-1 binding;GO:0035255|ionotropic glutamate receptor binding;GO:0050135|NAD(P)+ nucleosidase activity;GO:0061809|NAD+ nucleotidase, cyclic ADP-ribose generating;","K04386","IL1R1, CD121a; interleukin 1 receptor type I"]
["ENSRNOG00000017277",73,4.696121987,406,26.21211502,0.179158453,-2.480691978,{"v":2.70589e-57,"d":"2.71E-57"},{"v":9.74413e-57,"d":"9.74E-57"},"down","yes","Igsf6","protein_coding","chr1:175610167-175620722:-","gi|149068040|gb|EDM17592.1|",1123,{"v":2e-145,"d":"2.00E-145"},"immunoglobulin superfamily, member 6 [Rattus norvegicus]","gi|451958097|ref|NM_133542.2|",2223,0,"Rattus norvegicus immunoglobulin superfamily, member 6 (Igsf6), mRNA","Q9Z0K5",434,{"v":1e-145,"d":"1.00E-145"},"Immunoglobulin superfamily member 6",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000006418",78,5.017774178,417,26.92229548,0.186379879,-2.423681974,{"v":2.70853e-57,"d":"2.71E-57"},{"v":9.74747e-57,"d":"9.75E-57"},"down","yes","Samhd1","protein_coding","chr3:145761558-145794386:-","gi|403225011|ref|NP_001178672.1|",2980,0,"deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [Rattus norvegicus]","gi|403225010|ref|NM_001191743.1|",2036,0,"Rattus norvegicus SAM domain and HD domain, 1 (Samhd1), mRNA","Q60710",1044,0,"Deoxynucleoside triphosphate triphosphohydrolase SAMHD1","TM1547",132,{"v":1e-31,"d":"1.00E-31"},"COG1078","pfam01966","HD","HD domain. HD domains are metal dependent phosphohydrolases.","GO:0000724|double-strand break repair via homologous recombination;GO:0006203|dGTP catabolic process;GO:0006974|cellular response to DNA damage stimulus;GO:0009264|deoxyribonucleotide catabolic process;GO:0016446|somatic hypermutation of immunoglobulin genes;GO:0045088|regulation of innate immune response;GO:0046061|dATP catabolic process;GO:0051289|protein homotetramerization;GO:0051607|defense response to virus;GO:0060339|negative regulation of type I interferon-mediated signaling pathway;GO:0090501|RNA phosphodiester bond hydrolysis;GO:0110025|DNA strand resection involved in replication fork processing;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0035861|site of double-strand break;GO:0097197|tetraspanin-enriched microdomain;","GO:0003676|nucleic acid binding;GO:0003697|single-stranded DNA binding;GO:0003723|RNA binding;GO:0004540|ribonuclease activity;GO:0005525|GTP binding;GO:0008270|zinc ion binding;GO:0008832|dGTPase activity;GO:0016793|triphosphoric monoester hydrolase activity;GO:0032567|dGTP binding;GO:0042802|identical protein binding;","K22544","SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]"]
["ENSRNOG00000060665",409,26.31114922,994,64.1744885,0.409993906,-1.286325628,{"v":4.59025e-57,"d":"4.59E-57"},{"v":1.64779E-56,"d":"1.65E-56"},"down","yes","Afap1","protein_coding","chr14:74743320-74856263:-","gi|672076537|ref|XP_008768469.1|",3377,0,"PREDICTED: actin filament-associated protein 1 isoform X3 [Rattus norvegicus]","gi|672076536|ref|XM_008770247.1|",3245,0,"PREDICTED: Rattus norvegicus actin filament associated protein 1 (Afap1), transcript variant X3, mRNA","Q80YS6",833,0,"Actin filament-associated protein 1",".",".",".",".","pfam00169","PH","PH domain. PH stands for pleckstrin homology.","GO:0007165|signal transduction;GO:0009966|regulation of signal transduction;GO:0051493|regulation of cytoskeleton organization;GO:0071260|cellular response to mechanical stimulus;","GO:0005829|cytosol;GO:0005884|actin filament;GO:0005925|focal adhesion;GO:0015629|actin cytoskeleton;","GO:0003779|actin binding;GO:0005515|protein binding;GO:0017124|SH3 domain binding;GO:0042169|SH2 domain binding;","K18616","AFAP1; actin filament associated protein 1"]
["ENSRNOG00000000130",193,12.41577457,639,41.25502832,0.300951789,-1.732395703,{"v":5.22357e-57,"d":"5.22E-57"},{"v":1.87278e-56,"d":"1.87E-56"},"down","yes","Dnajb5","protein_coding","chr5:57176845-57185490:+","gi|568927081|ref|XP_006538173.1|",2064,0,"PREDICTED: dnaJ homolog subfamily B member 5 isoform X4 [Mus musculus]","gi|157819426|ref|NM_001108004.1|",2405,0,"Rattus norvegicus DnaJ heat shock protein family (Hsp40) member B5 (Dnajb5), mRNA","O89114",652,0,"DnaJ homolog subfamily B member 5",".",".",".",".","pfam00226","DnaJ","DnaJ domain. DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006986|response to unfolded protein;GO:0051085|chaperone cofactor-dependent protein refolding;","GO:0005634|nucleus;GO:0005829|cytosol;","GO:0051082|unfolded protein binding;GO:0051087|chaperone binding;","K09511","DNAJB5; DnaJ homolog subfamily B member 5"]
["ENSRNOG00000053430",6,0.385982629,235,15.17203702,0.025440396,-5.296735065,{"v":5.54808e-57,"d":"5.55E-57"},{"v":1.98663E-56,"d":"1.99E-56"},"down","yes","Slco4a1","protein_coding","chr3:167559316-167578305:+","gi|67514562|ref|NP_598292.2|",3194,0,"solute carrier organic anion transporter family member 4A1 [Rattus norvegicus]","gi|67514561|ref|NM_133608.2|",2964,0,"Rattus norvegicus solute carrier organic anion transporter family, member 4a1 (Slco4a1), mRNA","Q99N01",1229,0,"Solute carrier organic anion transporter family member 4A1",".",".",".",".","pfam03137","OATP","Organic Anion Transporter Polypeptide (OATP) family. This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.","GO:0006811|ion transport;GO:0042403|thyroid hormone metabolic process;GO:0043252|sodium-independent organic anion transport;GO:0055085|transmembrane transport;GO:0070327|thyroid hormone transport;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;","GO:0015347|sodium-independent organic anion transmembrane transporter activity;GO:0015349|thyroid hormone transmembrane transporter activity;GO:0022857|transmembrane transporter activity;","K14354","SLCO4A; solute carrier organic anion transporter family, member 4A"]
["ENSRNOG00000015658",678,43.61603709,1390,89.74098492,0.486021377,-1.040908324,{"v":6.71427e-57,"d":"6.71E-57"},{"v":2.39971e-56,"d":"2.40E-56"},"down","yes","Sorbs1","protein_coding","chr1:239108777-239330169:-","gi|755562948|ref|XP_011245485.1|",6760,0,"PREDICTED: sorbin and SH3 domain-containing protein 1 isoform X21 [Mus musculus]","gi|755562976|ref|XM_011247193.1|",2860,0,"PREDICTED: Mus musculus sorbin and SH3 domain containing 1 (Sorbs1), transcript variant X41, mRNA","Q9BX66",1782,0,"Sorbin and SH3 domain-containing protein 1",".",".",".",".","pfam02208","Sorb","Sorbin homologous domain.","GO:0008286|insulin receptor signaling pathway;GO:0014823|response to activity;GO:0031667|response to nutrient levels;GO:0032868|response to insulin;GO:0032869|cellular response to insulin stimulus;GO:0033993|response to lipid;GO:0042594|response to starvation;GO:0043149|stress fiber assembly;GO:0045725|positive regulation of glycogen biosynthetic process;GO:0046326|positive regulation of glucose import;GO:0046628|positive regulation of insulin receptor signaling pathway;GO:0046889|positive regulation of lipid biosynthetic process;GO:0048041|focal adhesion assembly;GO:0095500|acetylcholine receptor signaling pathway;GO:1903078|positive regulation of protein localization to plasma membrane;GO:1904393|regulation of skeletal muscle acetylcholine-gated channel clustering;GO:1904608|response to monosodium L-glutamate;","GO:0001725|stress fiber;GO:0005634|nucleus;GO:0005813|centrosome;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0005899|insulin receptor complex;GO:0005912|adherens junction;GO:0005925|focal adhesion;GO:0016020|membrane;GO:0016363|nuclear matrix;GO:0016600|flotillin complex;GO:0030055|cell-substrate junction;GO:0045121|membrane raft;GO:0045202|synapse;","GO:0005158|insulin receptor binding;GO:0019901|protein kinase binding;GO:0030159|receptor signaling complex scaffold activity;GO:0031625|ubiquitin protein ligase binding;","K06086","SORBS1, SH3D5, PONSIN, CAP; sorbin and SH3 domain containing protein 1"]
["ENSRNOG00000019728",72,4.631791549,402,25.95386758,0.178462479,-2.486307309,{"v":6.87446E-57,"d":"6.87E-57"},{"v":2.45542e-56,"d":"2.46E-56"},"down","yes","Itgam","protein_coding","chr1:182659000-182709503:+","gi|149067646|gb|EDM17198.1|",6066,0,"integrin alpha M [Rattus norvegicus]","gi|672038371|ref|XM_006230214.2|",4009,0,"PREDICTED: Rattus norvegicus integrin, alpha M (Itgam), transcript variant X1, mRNA","P05555",2066,0,"Integrin alpha-M",".",".",".",".","pfam08441","Integrin_alpha2","Integrin alpha. This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.","GO:0001774|microglial cell activation;GO:0001781|neutrophil apoptotic process;GO:0002523|leukocyte migration involved in inflammatory response;GO:0006898|receptor-mediated endocytosis;GO:0006909|phagocytosis;GO:0006911|phagocytosis, engulfment;GO:0007155|cell adhesion;GO:0007159|leukocyte cell-cell adhesion;GO:0007229|integrin-mediated signaling pathway;GO:0010668|ectodermal cell differentiation;GO:0014005|microglia development;GO:0030593|neutrophil chemotaxis;GO:0030900|forebrain development;GO:0032930|positive regulation of superoxide anion generation;GO:0034113|heterotypic cell-cell adhesion;GO:0043315|positive regulation of neutrophil degranulation;GO:0045123|cellular extravasation;GO:0045963|negative regulation of dopamine metabolic process;GO:0050798|activated T cell proliferation;GO:0060376|positive regulation of mast cell differentiation;GO:0061756|leukocyte adhesion to vascular endothelial cell;GO:0090314|positive regulation of protein targeting to membrane;GO:0097190|apoptotic signaling pathway;GO:0097242|amyloid-beta clearance;GO:0098609|cell-cell adhesion;GO:0110090|positive regulation of hippocampal neuron apoptotic process;GO:0150062|complement-mediated synapse pruning;GO:0150064|vertebrate eye-specific patterning;GO:1901216|positive regulation of neuron death;GO:1903223|positive regulation of oxidative stress-induced neuron death;GO:1904151|positive regulation of microglial cell mediated cytotoxicity;GO:1905114|cell surface receptor signaling pathway involved in cell-cell signaling;GO:2000363|positive regulation of prostaglandin-E synthase activity;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0008305|integrin complex;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0034688|integrin alphaM-beta2 complex;GO:0044853|plasma membrane raft;","GO:0001846|opsonin binding;GO:0001851|complement component C3b binding;GO:0008201|heparin binding;GO:0031072|heat shock protein binding;GO:0038024|cargo receptor activity;GO:0043395|heparan sulfate proteoglycan binding;GO:0044877|protein-containing complex binding;GO:0046872|metal ion binding;","K06461","ITGAM, CD11b; integrin alpha MK06461; K06594"]
["ENSRNOG00000009204",148,9.520904851,556,35.89639397,0.265232905,-1.914668326,{"v":6.93547e-57,"d":"6.94E-57"},{"v":2.47566e-56,"d":"2.48E-56"},"down","yes","Il17re","protein_coding","chr4:146605526-146618206:+","gi|51890226|ref|NP_001004091.1|",2814,0,"interleukin-17 receptor E precursor [Rattus norvegicus]","gi|51890225|ref|NM_001004091.1|",2610,0,"Rattus norvegicus interleukin 17 receptor E (Il17re), mRNA","Q6AZ51",1088,0,"Interleukin-17 receptor E",".",".",".",".","pfam15037","IL17_R_N","Interleukin-17 receptor extracellular region. This domain is found at the N-terminus (extracellular region) of interleukin-17 receptor C and Interleukin-17 receptor E. This is the presumed ligand-binding domain. Human putative interleukin-17 receptor E-like consists only of this domain.","GO:0006954|inflammatory response;GO:0019221|cytokine-mediated signaling pathway;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0030368|interleukin-17 receptor activity;","K05168","IL17RE; interleukin 17 receptor E"]
["ENSRNOG00000016013",449,28.88436674,1054,68.04820008,0.424469225,-1.236268136,{"v":7.08965e-57,"d":"7.09E-57"},{"v":2.52912e-56,"d":"2.53E-56"},"down","yes","Gprc5b","protein_coding","chr1:173316907-173340932:-","gi|564330619|ref|XP_006230171.1|",1852,0,"PREDICTED: G-protein coupled receptor family C group 5 member B isoform X2 [Rattus norvegicus]","gi|14269445|gb|AF378831.1|AF378831",3214,0,"Mus musculus orphan G protein-coupled receptor (Raig2) mRNA, complete cds","Q923Z0",693,0,"G-protein coupled receptor family C group 5 member B",".",".",".",".","pfam00003","7tm_3","7 transmembrane sweet-taste receptor of 3 GCPR. This is a domain of seven transmembrane regions that forms the C-terminus of some subclass 3 G-coupled-protein receptors. It is often associated with a downstream cysteine-rich linker domain, NCD3G pfam07562, which is the human sweet-taste receptor, and the N-terminal domain, ANF_receptor pfam01094. The seven TM regions assemble in such a way as to produce a docking pocket into which such molecules as cyclamate and lactisole have been found to bind and consequently confer the taste of sweetness.","GO:0001934|positive regulation of protein phosphorylation;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007626|locomotory behavior;GO:0010976|positive regulation of neuron projection development;GO:0032147|activation of protein kinase activity;GO:0042593|glucose homeostasis;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045666|positive regulation of neuron differentiation;GO:0045860|positive regulation of protein kinase activity;GO:0050729|positive regulation of inflammatory response;GO:0060907|positive regulation of macrophage cytokine production;GO:0061098|positive regulation of protein tyrosine kinase activity;GO:0090263|positive regulation of canonical Wnt signaling pathway;","GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0043235|receptor complex;GO:0045121|membrane raft;GO:0070062|extracellular exosome;","GO:0004930|G protein-coupled receptor activity;GO:0019901|protein kinase binding;GO:0030295|protein kinase activator activity;","K04619","GPRC5B; G protein-coupled receptor family C group 5 member B"]
["ENSRNOG00000018198",717,46.12492418,1444,93.22732534,0.494757562,-1.015206338,{"v":9.79269e-57,"d":"9.79E-57"},{"v":3.48903e-56,"d":"3.49E-56"},"down","yes","Dapk1","protein_coding","chr17:3930213-4090991:-","gi|564390196|ref|XP_006253584.1|",7362,0,"PREDICTED: death-associated protein kinase 1 isoform X2 [Rattus norvegicus]","gi|210032924|ref|NM_001107335.2|",5878,0,"Rattus norvegicus death associated protein kinase 1 (Dapk1), mRNA","Q80YE7",2817,0,"Death-associated protein kinase 1",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0002357|defense response to tumor cell;GO:0006468|protein phosphorylation;GO:0006915|apoptotic process;GO:0008625|extrinsic apoptotic signaling pathway via death domain receptors;GO:0010508|positive regulation of autophagy;GO:0017148|negative regulation of translation;GO:0035556|intracellular signal transduction;GO:0043065|positive regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0043280|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0046777|protein autophosphorylation;GO:0071346|cellular response to interferon-gamma;GO:0071447|cellular response to hydroperoxide;GO:0097190|apoptotic signaling pathway;GO:1902042|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:2000310|regulation of NMDA receptor activity;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0015629|actin cytoskeleton;","GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0004683|calmodulin-dependent protein kinase activity;GO:0005516|calmodulin binding;GO:0005524|ATP binding;GO:0005525|GTP binding;GO:0017075|syntaxin-1 binding;GO:0042802|identical protein binding;","K08803","DAPK; death-associated protein kinase [EC:2.7.11.1]"]
["ENSRNOG00000016021",136,8.748939593,532,34.34690934,0.254722761,-1.973000214,{"v":1.19813E-56,"d":"1.20E-56"},{"v":4.26348e-56,"d":"4.26E-56"},"down","yes","Lims2","protein_coding","chr18:23553937-23592137:+","gi|564393097|ref|XP_006254658.1|",1688,0,"PREDICTED: LIM and senescent cell antigen-like-containing domain protein 2 isoform X1 [Rattus norvegicus]","gi|672083062|ref|XM_008772043.1|",1626,0,"PREDICTED: Rattus norvegicus LIM and senescent cell antigen like domains 2 (Lims2), transcript variant X3, mRNA","Q91XD2",646,0,"LIM and senescent cell antigen-like-containing domain protein 2",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.","GO:0043066|negative regulation of apoptotic process;GO:0045216|cell-cell junction organization;GO:0050680|negative regulation of epithelial cell proliferation;GO:0098609|cell-cell adhesion;GO:1900026|positive regulation of substrate adhesion-dependent cell spreading;GO:2000178|negative regulation of neural precursor cell proliferation;GO:2000346|negative regulation of hepatocyte proliferation;GO:2001046|positive regulation of integrin-mediated signaling pathway;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0005925|focal adhesion;","GO:0046872|metal ion binding;","K23354","LIMS1_2, PINCH1_2; LIM and senescent cell antigen-like-containing domain protein 1/2"]
["ENSRNOG00000016926",2,0.128660876,240,15.49484632,0.008303463,-6.912071215,{"v":1.25132e-56,"d":"1.25E-56"},{"v":4.44721e-56,"d":"4.45E-56"},"down","yes","Plekhs1","pseudogene","chr1:255495634-255525353:+","gi|197386957|ref|NP_001128085.1|",2427,0,"pleckstrin homology domain-containing family S member 1 [Rattus norvegicus]","gi|197386956|ref|NM_001134613.1|",2511,0,"Rattus norvegicus pleckstrin homology domain containing S1 (Plekhs1), mRNA",".",".",".",".",".",".",".",".","pfam12429","DUF3676","Protein of unknown function (DUF3676). This domain family is found in eukaryotes, and is approximately 230 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000005700",101,6.497374257,462,29.82757916,0.217831096,-2.198718178,{"v":1.67805e-56,"d":"1.68E-56"},{"v":5.94532E-56,"d":"5.95E-56"},"down","yes","Nsg1","protein_coding","chr14:72648741-72670514:+","gi|47059500|ref|NP_077042.2|",778,{"v":2e-97,"d":"2.00E-97"},"neuron-specific protein family member 1 [Rattus norvegicus]","gi|38014538|gb|BC060538.1|",1571,0,"Rattus norvegicus neuron specific gene family member 1, mRNA (cDNA clone MGC:72656 IMAGE:6921928), complete cds","P02683",304,{"v":6e-99,"d":"6.00E-99"},"Neuronal vesicle trafficking-associated protein 1",".",".",".",".","pfam06387","Calcyon","D1 dopamine receptor-interacting protein (calcyon). This family consists of several D1 dopamine receptor-interacting (calcyon) proteins. D1/D5 dopamine receptors in the basal ganglia, hippocampus, and cerebral cortex modulate motor, reward, and cognitive behaviour. D1-like dopamine receptors likely modulate neocortical and hippocampal neuronal excitability and synaptic function via Ca(2+) as well as cAMP-dependent signaling. Defective calcyon proteins have been implicated in both attention-deficit/hyperactivity disorder (ADHD) and schizophrenia.","GO:0001881|receptor recycling;GO:0001921|positive regulation of receptor recycling;GO:0006915|apoptotic process;GO:0007212|dopamine receptor signaling pathway;GO:0016197|endosomal transport;GO:0042982|amyloid precursor protein metabolic process;GO:0048268|clathrin coat assembly;GO:0098814|spontaneous synaptic transmission;GO:0098887|neurotransmitter receptor transport, endosome to postsynaptic membrane;GO:0099003|vesicle-mediated transport in synapse;GO:0099627|neurotransmitter receptor cycle;GO:0099630|postsynaptic neurotransmitter receptor cycle;GO:1900271|regulation of long-term synaptic potentiation;","GO:0005768|endosome;GO:0005769|early endosome;GO:0005770|late endosome;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0016328|lateral plasma membrane;GO:0030425|dendrite;GO:0031901|early endosome membrane;GO:0032580|Golgi cisterna membrane;GO:0032585|multivesicular body membrane;GO:0032588|trans-Golgi network membrane;GO:0036477|somatodendritic compartment;GO:0043202|lysosomal lumen;GO:0045211|postsynaptic membrane;GO:0055038|recycling endosome membrane;GO:0098845|postsynaptic endosome;GO:0098978|glutamatergic synapse;","GO:0005102|signaling receptor binding;GO:0005515|protein binding;GO:0032051|clathrin light chain binding;",".","."]
["ENSRNOG00000009068",641,41.23581088,1334,86.12552078,0.478787362,-1.062543024,{"v":1.72791E-56,"d":"1.73E-56"},{"v":6.11819e-56,"d":"6.12E-56"},"down","yes","Phlda3","protein_coding","chr13:47193086-47196335:+","gi|58865988|ref|NP_001012206.1|",609,{"v":3e-73,"d":"3.00E-73"},"pleckstrin homology-like domain family A member 3 [Rattus norvegicus]","gi|241666431|ref|NM_001012206.2|",1424,0,"Rattus norvegicus pleckstrin homology-like domain, family A, member 3 (Phlda3), mRNA","Q5PQT7",239,{"v":1e-74,"d":"1.00E-74"},"Pleckstrin homology-like domain family A member 3",".",".",".",".","pfam00169","PH","PH domain. PH stands for pleckstrin homology.","GO:0042771|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0043065|positive regulation of apoptotic process;GO:0051898|negative regulation of protein kinase B signaling;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;","GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;GO:0010314|phosphatidylinositol-5-phosphate binding;GO:0032266|phosphatidylinositol-3-phosphate binding;GO:0043325|phosphatidylinositol-3,4-bisphosphate binding;GO:0080025|phosphatidylinositol-3,5-bisphosphate binding;","K23793","PHLDA; pleckstrin homology-like domain family A"]
["ENSRNOG00000016688",255,16.40426174,742,47.90489986,0.342433901,-1.546102559,{"v":2.87935e-56,"d":"2.88E-56"},{"v":1.01637E-55,"d":"1.02E-55"},"down","yes","Ston1","protein_coding","chr6:5843185-5892449:-","gi|281427176|ref|NP_891999.2|",3555,0,"stonin-1 [Rattus norvegicus]","gi|672055393|ref|XM_008764479.1|",2745,0,"PREDICTED: Rattus norvegicus stonin 1 (Ston1), transcript variant X1, mRNA","Q8CDJ8",1213,0,"Stonin-1",".",".",".",".","pfam00928","Adap_comp_sub","Adaptor complexes medium subunit family. This family also contains members which are coatomer subunits.","GO:0006897|endocytosis;GO:0006929|substrate-dependent cell migration;GO:0016192|vesicle-mediated transport;GO:0030100|regulation of endocytosis;GO:0048008|platelet-derived growth factor receptor signaling pathway;GO:0048041|focal adhesion assembly;GO:0048488|synaptic vesicle endocytosis;GO:0097178|ruffle assembly;GO:0120181|focal adhesion disassembly;","GO:0005905|clathrin-coated pit;GO:0008021|synaptic vesicle;GO:0030136|clathrin-coated vesicle;GO:0031252|cell leading edge;GO:0031410|cytoplasmic vesicle;GO:0042995|cell projection;","GO:0035615|clathrin adaptor activity;","K20067","STON1_2; stonin-1/2"]
["ENSRNOG00000050539",336,21.61502723,874,56.42706534,0.383061339,-1.384352666,{"v":3.35207e-56,"d":"3.35E-56"},{"v":1.1825e-55,"d":"1.18E-55"},"down","yes","Fbln5","protein_coding","chr6:120899224-120977755:-","gi|564357000|ref|XP_006240521.1|",2240,0,"PREDICTED: fibulin-5 isoform X1 [Rattus norvegicus]","gi|672056443|ref|XM_006240459.2|",1633,0,"PREDICTED: Rattus norvegicus fibulin 5 (Fbln5), transcript variant X1, mRNA","Q9WVH8",828,0,"Fibulin-5",".",".",".",".","pfam14670","FXa_inhibition","Coagulation Factor Xa inhibitory site. This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001558|regulation of cell growth;GO:0007155|cell adhesion;GO:0016525|negative regulation of angiogenesis;GO:0030198|extracellular matrix organization;GO:0033690|positive regulation of osteoblast proliferation;GO:0034394|protein localization to cell surface;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046903|secretion;GO:0048251|elastic fiber assembly;GO:0098867|intramembranous bone growth;GO:2000121|regulation of removal of superoxide radicals;","GO:0005615|extracellular space;GO:0062023|collagen-containing extracellular matrix;GO:0071953|elastic fiber;","GO:0005178|integrin binding;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0008022|protein C-terminus binding;GO:0042803|protein homodimerization activity;","K17340","FBLN5; fibulin 5"]
["ENSRNOG00000003553",361,23.22328818,912,58.88041601,0.394414472,-1.342215607,{"v":5.99805e-56,"d":"6.00E-56"},{"v":2.10811e-55,"d":"2.11E-55"},"down","yes","Efemp1","protein_coding","chr14:102610908-102690018:+","gi|58865654|ref|NP_001012039.1|",2554,0,"EGF-containing fibulin-like extracellular matrix protein 1 precursor [Rattus norvegicus]","gi|58865653|ref|NM_001012039.1|",2006,0,"Rattus norvegicus EGF-containing fibulin-like extracellular matrix protein 1 (Efemp1), mRNA","O35568",986,0,"EGF-containing fibulin-like extracellular matrix protein 1",".",".",".",".","pfam07645","EGF_CA","Calcium-binding EGF domain.","GO:0006355|regulation of transcription, DNA-templated;GO:0007173|epidermal growth factor receptor signaling pathway;GO:0008284|positive regulation of cell proliferation;GO:0010977|negative regulation of neuron projection development;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0031346|positive regulation of cell projection organization;GO:0032331|negative regulation of chondrocyte differentiation;GO:0043010|camera-type eye development;GO:0048048|embryonic eye morphogenesis;GO:0048050|post-embryonic eye morphogenesis;GO:1903975|regulation of glial cell migration;","GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0062023|collagen-containing extracellular matrix;","GO:0005006|epidermal growth factor-activated receptor activity;GO:0005154|epidermal growth factor receptor binding;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0008083|growth factor activity;","K18262","EFEMP1, FBLN3; EGF-containing fibulin-like extracellular matrix protein 1"]
["ENSRNOG00000006956",98,6.304382942,453,29.24652242,0.215560088,-2.213838015,{"v":6.82841e-56,"d":"6.83E-56"},{"v":2.397e-55,"d":"2.40E-55"},"down","yes","Adamtsl1","protein_coding","chr5:99964486-100918384:+","gi|568927629|ref|XP_006538438.1|",9126,0,"PREDICTED: ADAMTS-like protein 1 isoform X2 [Mus musculus]","gi|672019521|ref|XM_008775991.1|",6227,0,"PREDICTED: Rattus norvegicus ADAMTS-like 1 (Adamtsl1), transcript variant X1, mRNA","Q8BLI0",3318,0,"ADAMTS-like protein 1",".",".",".",".","pfam08686","PLAC","PLAC (protease and lacunin) domain. The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.",".",".",".",".","."]
["ENSRNOG00000008425",263,16.91890524,753,48.61508032,0.348017634,-1.522767685,{"v":7.45141E-56,"d":"7.45E-56"},{"v":2.61248e-55,"d":"2.61E-55"},"down","yes","Nav1","protein_coding","chr13:46873689-47126449:-","gi|564315808|ref|XP_006221540.1|",9796,0,"PREDICTED: neuron navigator 1 isoform X1 [Rattus norvegicus]","gi|672027123|ref|XM_006221478.2|",7074,0,"PREDICTED: Rattus norvegicus similar to neuron navigator 1 (LOC685707), transcript variant X1, mRNA","Q8CH77",3209,0,"Neuron navigator 1",".",".",".",".","pfam05956","APC_basic","APC basic domain. This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.","GO:0001578|microtubule bundle formation;GO:0001764|neuron migration;GO:0007399|nervous system development;","GO:0015630|microtubule cytoskeleton;GO:0043194|axon initial segment;",".","K16776","NAV1; neuron navigator 1"]
["ENSRNOG00000024620",14,0.900626135,251,16.20502677,0.055576961,-4.169369251,{"v":8.87829e-56,"d":"8.88E-56"},{"v":3.11084E-55,"d":"3.11E-55"},"down","yes","Mamdc2","protein_coding","chr1:220863976-221016354:-","gi|564298967|ref|XP_006223741.1|",3605,0,"PREDICTED: MAM domain-containing protein 2 isoform X1 [Rattus norvegicus]","gi|672014738|ref|XM_006223679.2|",3372,0,"PREDICTED: Rattus norvegicus MAM domain containing 2 (Mamdc2), transcript variant X1, mRNA","Q8CG85",1330,0,"MAM domain-containing protein 2",".",".",".",".","pfam00629","MAM","MAM domain. An extracellular domain found in many receptors.",".",".",".",".","."]
["ENSRNOG00000063811",309,19.8781054,828,53.45721979,0.371850715,-1.427204549,{"v":9.03784e-56,"d":"9.04E-56"},{"v":3.1648e-55,"d":"3.16E-55"},"down","yes","RGD1562339","protein_coding","chr11:79345304-79396142:+","gi|293340917|ref|XP_001058431.2|",1221,{"v":9e-151,"d":"9.00E-151"},"PREDICTED: UPF0524 protein C3orf70 homolog [Rattus norvegicus]","gi|672026246|ref|XM_001058431.4|",5223,0,"PREDICTED: Rattus norvegicus RGD1562339 (RGD1562339), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam13885","Keratin_B2_2","Keratin, high sulfur B2 protein.",".",".",".",".","."]
["ENSRNOG00000000825",5,0.321652191,228,14.720104,0.021851217,-5.516142539,{"v":1.29416E-55,"d":"1.29E-55"},{"v":4.52623e-55,"d":"4.53E-55"},"down","yes","Calhm5","protein_coding","chr20:26066242-26072272:-","gi|68163381|ref|NP_001020148.1|",1650,0,"protein FAM26E [Rattus norvegicus]","gi|68163380|ref|NM_001024977.1|",1024,0,"Rattus norvegicus family with sequence similarity 26, member E (Fam26e), mRNA","Q5FWS4",640,0,"Calcium homeostasis modulator protein 5",".",".",".",".","pfam14798","Ca_hom_mod","Calcium homeostasis modulator. This family of proteins control cytosolic calcium concentration. They are transmembrane proteins which may be pore-forming ion channels.","GO:0098655|cation transmembrane transport;","GO:0005887|integral component of plasma membrane;","GO:0005261|cation channel activity;",".","."]
["ENSRNOG00000020948",72,4.631791549,396,25.56649642,0.181166456,-2.464612238,{"v":1.58381E-55,"d":"1.58E-55"},{"v":5.5325e-55,"d":"5.53E-55"},"down","yes","Pth1r","protein_coding","chr8:110697485-110719729:-","gi|149018420|gb|EDL77061.1|",2641,0,"parathyroid hormone receptor 1, isoform CRA_a [Rattus norvegicus]","gi|672063468|ref|XM_006244002.2|",1718,0,"PREDICTED: Rattus norvegicus parathyroid hormone 1 receptor (Pth1r), transcript variant X5, mRNA","P25961",1000,0,"Parathyroid hormone/parathyroid hormone-related peptide receptor",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0001501|skeletal system development;GO:0001503|ossification;GO:0001701|in utero embryonic development;GO:0002062|chondrocyte differentiation;GO:0002076|osteoblast development;GO:0006874|cellular calcium ion homeostasis;GO:0007166|cell surface receptor signaling pathway;GO:0007187|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007188|adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007568|aging;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0030282|bone mineralization;GO:0045453|bone resorption;GO:0048469|cell maturation;GO:0060732|positive regulation of inositol phosphate biosynthetic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0031526|brush border membrane;GO:0043235|receptor complex;","GO:0004991|parathyroid hormone receptor activity;GO:0008528|G protein-coupled peptide receptor activity;GO:0017046|peptide hormone binding;GO:0042803|protein homodimerization activity;GO:0043621|protein self-association;","K04585","PTHR1; parathyroid hormone receptor 1"]
["ENSRNOG00000012989",14,0.900626135,250,16.14046491,0.055799268,-4.163609982,{"v":1.60196E-55,"d":"1.60E-55"},{"v":5.59248e-55,"d":"5.59E-55"},"down","yes","Serinc2","protein_coding","chr5:142592309-142618364:-","gi|72255537|ref|NP_001026826.1|",1967,0,"serine incorporator 2 precursor [Rattus norvegicus]","gi|72255536|ref|NM_001031656.1|",1803,0,"Rattus norvegicus serine incorporator 2 (Serinc2), mRNA","Q8K0E7",747,0,"Serine incorporator 2",".",".",".",".","pfam03348","Serinc","Serine incorporator (Serinc). This is a family of eukaryotic membrane proteins which incorporate serine into membranes and facilitate the synthesis of the serine-derived lipids phosphatidylserine and sphingolipid. Members of this family contain 11 transmembrane domains and form intracellular complexes with key enzymes involved in serine and sphingolipid biosynthesis.","GO:0006658|phosphatidylserine metabolic process;GO:0006665|sphingolipid metabolic process;GO:1904219|positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity;GO:1904222|positive regulation of serine C-palmitoyltransferase activity;","GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0030674|protein binding, bridging;","K24176","SERINC2; serine incorporator 2"]
["ENSRNOG00000011994",7,0.450313067,231,14.91378958,0.030194409,-5.049574739,{"v":1.65294e-55,"d":"1.65E-55"},{"v":5.76693e-55,"d":"5.77E-55"},"down","yes","Perp","protein_coding","chr1:13542067-13554511:+","gi|157820213|ref|NP_001099735.1|",943,{"v":6e-121,"d":"6.00E-121"},"p53 apoptosis effector related to PMP-22 [Rattus norvegicus]","gi|186910194|ref|NM_001106265.2|",1869,0,"Rattus norvegicus PERP, TP53 apoptosis effector (Perp), mRNA","Q9JK95",355,{"v":7e-118,"d":"7.00E-118"},"p53 apoptosis effector related to PMP-22",".",".",".",".","pfam13903","Claudin_2","PMP-22/EMP/MP20/Claudin tight junction. Members of this family are claudins, that form tight junctions between cells.","GO:0002934|desmosome organization;GO:0007219|Notch signaling pathway;GO:0034113|heterotypic cell-cell adhesion;GO:0045862|positive regulation of proteolysis;GO:0072332|intrinsic apoptotic signaling pathway by p53 class mediator;GO:0097186|amelogenesis;GO:0097202|activation of cysteine-type endopeptidase activity;GO:0098609|cell-cell adhesion;","GO:0005739|mitochondrion;GO:0005794|Golgi apparatus;GO:0005887|integral component of plasma membrane;GO:0005911|cell-cell junction;",".","K10136","PERP; TP53 apoptosis effector"]
["ENSRNOG00000022764",13,0.836295696,247,15.94677933,0.052442921,-4.253108133,{"v":1.71583e-55,"d":"1.72E-55"},{"v":5.98267e-55,"d":"5.98E-55"},"down","yes","Evi2a","protein_coding","chr10:64485200-64489843:-","gi|112983874|ref|NP_001037752.1|",1170,{"v":1E-150,"d":"1.00E-150"},"protein EVI2A precursor [Rattus norvegicus]","gi|281371508|gb|AC123294.3|",2519,0,"Rattus norvegicus BAC CH230-333F9 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P20934",379,{"v":6e-123,"d":"6.00E-123"},"Protein EVI2A",".",".",".",".","pfam05399","EVI2A","Ectropic viral integration site 2A protein (EVI2A). This family contains several mammalian ectropic viral integration site 2A (EVI2A) proteins. The function of this protein is unknown although it is thought to be a membrane protein and may function as an oncogene in retrovirus induced myeloid tumors.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000020058",225,14.47434859,686,44.28943572,0.326812667,-1.613464194,{"v":2.24894e-55,"d":"2.25E-55"},{"v":7.82719e-55,"d":"7.83E-55"},"down","yes","Celsr2","protein_coding","chr2:196029434-196053845:-","gi|300798056|ref|NP_001178039.1|",14359,0,"cadherin EGF LAG seven-pass G-type receptor 2 precursor [Rattus norvegicus]","gi|672043856|ref|XM_006233192.2|",10609,0,"PREDICTED: Rattus norvegicus cadherin, EGF LAG seven-pass G-type receptor 2 (Celsr2), transcript variant X1, mRNA","Q9R0M0",5357,0,"Cadherin EGF LAG seven-pass G-type receptor 2",".",".",".",".","pfam12003","DUF3497","Domain of unknown function (DUF3497). This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 213 to 257 amino acids in length. This domain is found associated with pfam02793, pfam00002, pfam01825. This domain has a single completely conserved residue W that may be functionally important.","GO:0001764|neuron migration;GO:0003341|cilium movement;GO:0006355|regulation of transcription, DNA-templated;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007283|spermatogenesis;GO:0016055|Wnt signaling pathway;GO:0021591|ventricular system development;GO:0021999|neural plate anterior/posterior regionalization;GO:0022407|regulation of cell-cell adhesion;GO:0032880|regulation of protein localization;GO:0033326|cerebrospinal fluid secretion;GO:0048813|dendrite morphogenesis;GO:0060271|cilium assembly;GO:0098609|cell-cell adhesion;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0005509|calcium ion binding;","K04601","CELSR2; cadherin EGF LAG seven-pass G-type receptor 2"]
["ENSRNOG00000004932",56,3.602504538,359,23.17770762,0.155429717,-2.685665731,{"v":2.27067e-55,"d":"2.27E-55"},{"v":7.898e-55,"d":"7.90E-55"},"down","yes","Sel1l3","protein_coding","chr14:57775501-57882644:+","gi|564383849|ref|XP_006251095.1|",5691,0,"PREDICTED: protein sel-1 homolog 3 isoform X3 [Rattus norvegicus]","gi|672076359|ref|XM_006251033.2|",4056,0,"PREDICTED: Rattus norvegicus sel-1 suppressor of lin-12-like 3 (C. elegans) (Sel1l3), transcript variant X3, mRNA","Q80TS8",2073,0,"Protein sel-1 homolog 3","STM0654",81.3,{"v":3e-15,"d":"3.00E-15"},"COG0790","pfam08238","Sel1","Sel1 repeat. This short repeat is found in the Sel1 protein. It is related to TPR repeats.",".","GO:0005654|nucleoplasm;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000015894",189,12.15845282,623,40.22203857,0.302283356,-1.726026548,{"v":2.38273E-55,"d":"2.38E-55"},{"v":8.28271e-55,"d":"8.28E-55"},"down","yes","Dock8","protein_coding","chr1:222649309-222842474:+","gi|197927178|ref|NP_001032882.2|",10548,0,"dedicator of cytokinesis protein 8 [Rattus norvegicus]","gi|672040011|ref|XM_008760310.1|",7223,0,"PREDICTED: Rattus norvegicus dedicator of cytokinesis 8 (Dock8), transcript variant X3, mRNA","Q8C147",3985,0,"Dedicator of cytokinesis protein 8",".",".",".",".","pfam06920","Ded_cyto","Dedicator of cytokinesis. This family represents a conserved region approximately 200 residues long within a number of eukaryotic dedicator of cytokinesis proteins. These are potential guanine nucleotide exchange factors, which activate some small GTPases by exchanging bound GDP for free GTP.","GO:0001771|immunological synapse formation;GO:0007264|small GTPase mediated signal transduction;GO:0036336|dendritic cell migration;GO:0043547|positive regulation of GTPase activity;GO:0061485|memory T cell proliferation;GO:0070233|negative regulation of T cell apoptotic process;GO:1903905|positive regulation of establishment of T cell polarity;GO:1990869|cellular response to chemokine;GO:2000406|positive regulation of T cell migration;","GO:0005737|cytoplasm;GO:0031252|cell leading edge;GO:0031256|leading edge membrane;","GO:0005085|guanyl-nucleotide exchange factor activity;","K21852","DOCK6_7_8; dedicator of cytokinesis protein 6/7/8"]
["ENSRNOG00000008785",27,1.736921831,286,18.46469186,0.094067198,-3.410164454,{"v":2.49447E-55,"d":"2.49E-55"},{"v":8.66586e-55,"d":"8.67E-55"},"down","yes","Klf5","protein_coding","chr15:76064258-76079445:+","gi|148668134|gb|EDL00464.1|",2154,0,"Kruppel-like factor 5, isoform CRA_a, partial [Mus musculus]","gi|77157784|ref|NM_053394.2|",3229,0,"Rattus norvegicus Kruppel-like factor 5 (Klf5), mRNA","Q9Z0Z7",807,0,"Krueppel-like factor 5",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001525|angiogenesis;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008284|positive regulation of cell proliferation;GO:0010468|regulation of gene expression;GO:0014816|skeletal muscle satellite cell differentiation;GO:0014901|satellite cell activation involved in skeletal muscle regeneration;GO:0014908|myotube differentiation involved in skeletal muscle regeneration;GO:0030033|microvillus assembly;GO:0032534|regulation of microvillus assembly;GO:0035914|skeletal muscle cell differentiation;GO:0043403|skeletal muscle tissue regeneration;GO:0045600|positive regulation of fat cell differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0060576|intestinal epithelial cell development;GO:0061586|positive regulation of transcription by transcription factor localization;GO:0071407|cellular response to organic cyclic compound;GO:0099156|cell-cell signaling via exosome;GO:1901653|cellular response to peptide;GO:1902895|positive regulation of pri-miRNA transcription by RNA polymerase II;GO:1990830|cellular response to leukemia inhibitory factor;GO:2000723|negative regulation of cardiac vascular smooth muscle cell differentiation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005794|Golgi apparatus;GO:0043231|intracellular membrane-bounded organelle;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0005515|protein binding;GO:0043426|MRF binding;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09206","KLF5; krueppel-like factor 5"]
["ENSRNOG00000003170",29,1.865582707,291,18.78750116,0.09929914,-3.332074967,{"v":3.16557E-55,"d":"3.17E-55"},{"v":1.09906E-54,"d":"1.10E-54"},"down","yes","Nlrp3","protein_coding","chr10:44328566-44352811:+","gi|300798702|ref|NP_001178571.1|",5138,0,"NACHT, LRR and PYD domains-containing protein 3 [Rattus norvegicus]","gi|300798701|ref|NM_001191642.1|",3857,0,"Rattus norvegicus NLR family, pyrin domain containing 3 (Nlrp3), mRNA","D4A523",1982,0,"NACHT, LRR and PYD domains-containing protein 3",".",".",".",".","pfam05729","NACHT","NACHT domain. This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.","GO:0002523|leukocyte migration involved in inflammatory response;GO:0002526|acute inflammatory response;GO:0002674|negative regulation of acute inflammatory response;GO:0002720|positive regulation of cytokine production involved in immune response;GO:0002830|positive regulation of type 2 immune response;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006954|inflammatory response;GO:0014070|response to organic cyclic compound;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0032691|negative regulation of interleukin-1 beta production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032736|positive regulation of interleukin-13 production;GO:0032753|positive regulation of interleukin-4 production;GO:0032754|positive regulation of interleukin-5 production;GO:0043280|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0044546|NLRP3 inflammasome complex assembly;GO:0045087|innate immune response;GO:0045471|response to ethanol;GO:0045630|positive regulation of T-helper 2 cell differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050727|regulation of inflammatory response;GO:0050728|negative regulation of inflammatory response;GO:0050830|defense response to Gram-positive bacterium;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051607|defense response to virus;GO:0071222|cellular response to lipopolysaccharide;GO:0071224|cellular response to peptidoglycan;GO:1901223|negative regulation of NIK/NF-kappaB signaling;GO:2000321|positive regulation of T-helper 17 cell differentiation;GO:2000553|positive regulation of T-helper 2 cell cytokine production;","GO:0000139|Golgi membrane;GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0061702|inflammasome complex;GO:0072559|NLRP3 inflammasome complex;","GO:0003674|molecular_function;GO:0005524|ATP binding;GO:0042802|identical protein binding;GO:0043565|sequence-specific DNA binding;","K12800","NLRP3, PYPAF1; NACHT, LRR and PYD domains-containing protein 3"]
["ENSRNOG00000008099",70,4.503130673,389,25.11456341,0.179303562,-2.479523947,{"v":6.08351e-55,"d":"6.08E-55"},{"v":2.10702E-54,"d":"2.11E-54"},"down","yes","Galnt12","protein_coding","chr5:61384571-61413354:+","gi|109476381|ref|XP_001066416.1|",2089,0,"PREDICTED: polypeptide N-acetylgalactosaminyltransferase 12 isoform X1 [Rattus norvegicus]","gi|672019296|ref|XM_001066416.5|",1703,0,"PREDICTED: Rattus norvegicus polypeptide N-acetylgalactosaminyltransferase 12 (Galnt12), transcript variant X1, mRNA","Q8BGT9",762,0,"Polypeptide N-acetylgalactosaminyltransferase 12",".",".",".",".","pfam00652","Ricin_B_lectin","Ricin-type beta-trefoil lectin domain.","GO:0006486|protein glycosylation;","GO:0000139|Golgi membrane;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;","GO:0004653|polypeptide N-acetylgalactosaminyltransferase activity;GO:0030246|carbohydrate binding;GO:0046872|metal ion binding;","K00710","GALNT; polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41]"]
["ENSRNOG00000062686",128,8.234296088,508,32.7974247,0.251065325,-1.993865306,{"v":6.67495e-55,"d":"6.67E-55"},{"v":2.30907e-54,"d":"2.31E-54"},"down","yes","Gcnt1","protein_coding","chr1:214718293-214758776:-","gi|11560101|ref|NP_071612.1|",2283,0,"beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase [Rattus norvegicus]","gi|672039927|ref|XM_006231147.2|",4505,0,"PREDICTED: Rattus norvegicus glucosaminyl (N-acetyl) transferase 1, core 2 (Gcnt1), transcript variant X1, mRNA","Q09324",836,0,"Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase",".",".",".",".","pfam02485","Branch","Core-2/I-Branching enzyme. This is a family of two different beta-1,6-N-acetylglucosaminyltransferase enzymes, I-branching enzyme and core-2 branching enzyme. I-branching enzyme is responsible for the production of the blood group I-antigen during embryonic development. Core-2 branching enzyme forms crucial side-chain branches in O-glycans.",".",".",".",".","."]
["ENSRNOG00000004276",258,16.59725305,739,47.71121429,0.347869014,-1.523383918,{"v":7.0072e-55,"d":"7.01E-55"},{"v":2.4196E-54,"d":"2.42E-54"},"down","yes","Itga3","protein_coding","chr10:79990161-80022118:-","gi|564313259|ref|XP_006220864.1|",5137,0,"PREDICTED: integrin alpha-3 isoform X1 [Rattus norvegicus]","gi|564313260|ref|XM_003752369.2|",3764,0,"PREDICTED: Rattus norvegicus integrin, alpha 3 (Itga3), transcript variant X4, mRNA","Q62470",1893,0,"Integrin alpha-3",".",".",".",".","pfam08441","Integrin_alpha2","Integrin alpha. This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.","GO:0001764|neuron migration;GO:0007155|cell adhesion;GO:0007229|integrin-mediated signaling pathway;GO:0007507|heart development;GO:0007613|memory;GO:0009410|response to xenobiotic stimulus;GO:0010628|positive regulation of gene expression;GO:0010634|positive regulation of epithelial cell migration;GO:0010811|positive regulation of cell-substrate adhesion;GO:0010976|positive regulation of neuron projection development;GO:0017015|regulation of transforming growth factor beta receptor signaling pathway;GO:0030111|regulation of Wnt signaling pathway;GO:0030324|lung development;GO:0030510|regulation of BMP signaling pathway;GO:0031345|negative regulation of cell projection organization;GO:0034698|response to gonadotropin;GO:0035024|negative regulation of Rho protein signal transduction;GO:0035640|exploration behavior;GO:0043588|skin development;GO:0048333|mesodermal cell differentiation;GO:0060135|maternal process involved in female pregnancy;GO:0072006|nephron development;GO:0097062|dendritic spine maintenance;GO:0097205|renal filtration;GO:1903078|positive regulation of protein localization to plasma membrane;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016323|basolateral plasma membrane;GO:0030426|growth cone;GO:0031527|filopodium membrane;GO:0034667|integrin alpha3-beta1 complex;GO:0043235|receptor complex;GO:0045202|synapse;GO:0048471|perinuclear region of cytoplasm;GO:0060076|excitatory synapse;GO:0071944|cell periphery;GO:0097060|synaptic membrane;GO:1990812|growth cone filopodium;","GO:0001968|fibronectin binding;GO:0002020|protease binding;GO:0005178|integrin binding;GO:0005515|protein binding;GO:0005518|collagen binding;GO:0019904|protein domain specific binding;GO:0043236|laminin binding;GO:0044877|protein-containing complex binding;GO:0046982|protein heterodimerization activity;","K06482","ITGA3, CD49c; integrin alpha 3"]
["ENSRNOG00000016794",366,23.54494038,913,58.94497787,0.399439295,-1.323951831,{"v":7.05974e-55,"d":"7.06E-55"},{"v":2.43627e-54,"d":"2.44E-54"},"down","yes","Phyhd1","protein_coding","chr3:13540056-13553797:+","gi|564339943|ref|XP_006233839.1|",1565,0,"PREDICTED: phytanoyl-CoA dioxygenase domain-containing protein 1 isoform X2 [Rattus norvegicus]","gi|672044897|ref|XM_006233779.2|",984,0,"PREDICTED: Rattus norvegicus phytanoyl-CoA dioxygenase domain containing 1 (Phyhd1), transcript variant X3, mRNA","Q5BJP9",575,0,"Phytanoyl-CoA dioxygenase domain-containing protein 1","all4427",56.6,7e-08,"COG5285","pfam05721","PhyH","Phytanoyl-CoA dioxygenase (PhyH). This family is made up of several eukaryotic phytanoyl-CoA dioxygenase (PhyH) proteins, ectoine hydroxylases and a number of bacterial deoxygenases. PhyH is a peroxisomal enzyme catalyzing the first step of phytanic acid alpha-oxidation. PhyH deficiency causes Refsum's disease (RD) which is an inherited neurological syndrome biochemically characterized by the accumulation of phytanic acid in plasma and tissues.",".",".","GO:0016706|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0046872|metal ion binding;",".","."]
["ENSRNOG00000038722",18,1.157947887,259,16.72152165,0.069248954,-3.852063906,{"v":7.1829e-55,"d":"7.18E-55"},{"v":2.47728E-54,"d":"2.48E-54"},"down","yes","Tlr1","protein_coding","chr14:43384932-43397125:+","gi|149035377|gb|EDL90081.1|",4050,0,"rCG56938 [Rattus norvegicus]","gi|451770385|ref|NM_001172120.2|",2565,0,"Rattus norvegicus toll-like receptor 1 (Tlr1), mRNA","Q9EPQ1",1340,0,"Toll-like receptor 1",".",".",".",".","pfam01582","TIR","TIR domain. The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.",".",".",".",".","."]
["ENSRNOG00000009482",84,5.403756808,419,27.0514192,0.199758718,-2.32366963,{"v":7.33471e-55,"d":"7.33E-55"},{"v":2.52659e-54,"d":"2.53E-54"},"down","yes","Emx2","protein_coding","chr1:258626584-258633594:+","gi|119964700|ref|NP_034262.2|",1086,{"v":2E-137,"d":"2.00E-137"},"homeobox protein EMX2 [Mus musculus]","gi|157821338|ref|NM_001109169.1|",2933,0,"Rattus norvegicus empty spiracles homeobox 2 (Emx2), mRNA","Q04744",422,{"v":8e-139,"d":"8.00E-139"},"Homeobox protein EMX2",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0007417|central nervous system development;GO:0007420|brain development;GO:0009410|response to xenobiotic stimulus;GO:0009952|anterior/posterior pattern specification;GO:0010468|regulation of gene expression;GO:0021542|dentate gyrus development;GO:0021796|cerebral cortex regionalization;GO:0021846|cell proliferation in forebrain;GO:0021885|forebrain cell migration;GO:0021987|cerebral cortex development;GO:0030182|neuron differentiation;GO:0030900|forebrain development;GO:0072197|ureter morphogenesis;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837|sequence-specific double-stranded DNA binding;","K09317","EMX; homeobox protein EMX"]
["ENSRNOG00000018770",163,10.48586142,573,36.99394558,0.283448042,-1.818843794,{"v":9.26212e-55,"d":"9.26E-55"},{"v":3.1886E-54,"d":"3.19E-54"},"down","yes","Pmaip1","protein_coding","chr18:59986017-59992429:+","gi|56605934|ref|NP_001008386.1|",530,{"v":3e-60,"d":"3.00E-60"},"phorbol-12-myristate-13-acetate-induced protein 1 [Rattus norvegicus]","gi|74180903|dbj|AK143990.1|",497,0,"Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530013M17 product:phorbol-12-myristate-13-acetate-induced protein 1, full insert sequence","Q5U777",208,{"v":1E-61,"d":"1.00E-61"},"Phorbol-12-myristate-13-acetate-induced protein 1",".",".",".",".","pfam15150","PMAIP1","Phorbol-12-myristate-13-acetate-induced. This family carries a BH3 domain between residues 23 and 40.","GO:0001836|release of cytochrome c from mitochondria;GO:0006915|apoptotic process;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006974|cellular response to DNA damage stimulus;GO:0008630|intrinsic apoptotic signaling pathway in response to DNA damage;GO:0009411|response to UV;GO:0010165|response to X-ray;GO:0010498|proteasomal protein catabolic process;GO:0010907|positive regulation of glucose metabolic process;GO:0010917|negative regulation of mitochondrial membrane potential;GO:0042149|cellular response to glucose starvation;GO:0042771|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0043029|T cell homeostasis;GO:0043065|positive regulation of apoptotic process;GO:0043280|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043331|response to dsRNA;GO:0043517|positive regulation of DNA damage response, signal transduction by p53 class mediator;GO:0043525|positive regulation of neuron apoptotic process;GO:0046902|regulation of mitochondrial membrane permeability;GO:0048147|negative regulation of fibroblast proliferation;GO:0051607|defense response to virus;GO:0070059|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0071456|cellular response to hypoxia;GO:0072332|intrinsic apoptotic signaling pathway by p53 class mediator;GO:0072593|reactive oxygen species metabolic process;GO:0090200|positive regulation of release of cytochrome c from mitochondria;GO:0097193|intrinsic apoptotic signaling pathway;GO:1900740|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:1902043|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:2001244|positive regulation of intrinsic apoptotic signaling pathway;","GO:0005634|nucleus;GO:0005739|mitochondrion;GO:0005829|cytosol;","GO:0003674|molecular_function;","K10131","PMAIP1, NOXA; phorbol-12-myristate-13-acetate-induced protein 1"]
["ENSRNOG00000023640",11,0.70763482,238,15.3657226,0.046052818,-4.440566764,{"v":1.19465E-54,"d":"1.19E-54"},{"v":4.11026e-54,"d":"4.11E-54"},"down","yes","Rab25","protein_coding","chr2:174000323-174006422:-","gi|164518908|ref|NP_001101157.2|",1132,{"v":6E-153,"d":"6.00E-153"},"ras-related protein Rab-25 [Rattus norvegicus]","gi|164518907|ref|NM_001107687.2|",1082,0,"Rattus norvegicus RAB25, member RAS oncogene family (Rab25), mRNA","Q9WTL2",435,{"v":2e-152,"d":"2.00E-152"},"Ras-related protein Rab-25","SPAC18G6.03",234,{"v":3e-74,"d":"3.00E-74"},"COG1100","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0003382|epithelial cell morphogenesis;GO:0006887|exocytosis;GO:0008284|positive regulation of cell proliferation;GO:0010634|positive regulation of epithelial cell migration;GO:0031268|pseudopodium organization;GO:0060627|regulation of vesicle-mediated transport;","GO:0005768|endosome;GO:0031143|pseudopodium;GO:0031410|cytoplasmic vesicle;GO:0055037|recycling endosome;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0031489|myosin V binding;","K07906","RAB25; Ras-related protein Rab-25"]
["ENSRNOG00000007611",21,1.350939202,266,17.17345467,0.078664382,-3.668145632,{"v":1.77595E-54,"d":"1.78E-54"},{"v":6.09554e-54,"d":"6.10E-54"},"down","yes","Hoxb7","protein_coding","chr10:81252553-81256034:+","gi|62945316|ref|NP_001017480.1|",1033,{"v":6e-137,"d":"6.00E-137"},"homeobox protein Hox-B7 [Rattus norvegicus]","gi|62945315|ref|NM_001017480.1|",1213,0,"Rattus norvegicus homeo box B7 (Hoxb7), mRNA","P18864",402,{"v":2e-138,"d":"2.00E-138"},"Homeobox protein Hox-B7",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0009952|anterior/posterior pattern specification;GO:0030099|myeloid cell differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048704|embryonic skeletal system morphogenesis;GO:0090190|positive regulation of branching involved in ureteric bud morphogenesis;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0016604|nuclear body;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09307","HOX_7; homeobox protein HoxA/B7"]
["ENSRNOG00000006079",78,5.017774178,404,26.0829913,0.192377252,-2.377989883,{"v":2.20944e-54,"d":"2.21E-54"},{"v":7.57429e-54,"d":"7.57E-54"},"down","yes","Psd4","protein_coding","chr3:7137155-7173571:+","gi|199561637|ref|NP_001128353.1|",4600,0,"PH and SEC7 domain-containing protein 4 [Rattus norvegicus]","gi|199561636|ref|NM_001134881.1|",4791,0,"Rattus norvegicus pleckstrin and Sec7 domain containing 4 (Psd4), mRNA","Q8BLR5",1566,0,"PH and SEC7 domain-containing protein 4","YDR170c",106,{"v":5e-22,"d":"5.00E-22"},"COG5307","pfam01369","Sec7","Sec7 domain. The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.","GO:0032012|regulation of ARF protein signal transduction;GO:0050790|regulation of catalytic activity;","GO:0032587|ruffle membrane;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0005543|phospholipid binding;","K12494","PSD; PH and SEC7 domain-containing protein"]
["ENSRNOG00000042445",104,6.690365571,458,29.56933172,0.22626029,-2.143944689,{"v":2.38894e-54,"d":"2.39E-54"},{"v":8.18474e-54,"d":"8.18E-54"},"down","yes","AC130970.1","protein_coding","chr10:101104209-101125693:+","gi|589962360|ref|XP_006993737.1|",6686,0,"PREDICTED: unconventional myosin-XV-like [Peromyscus maniculatus bairdii]","gi|672025732|ref|XR_600842.1|",5394,0,"PREDICTED: Rattus norvegicus similar to Myosin-15 (Myosin XV) (Unconventional myosin-15) (LOC690323), misc_RNA","Q96JP2",1385,0,"Unconventional myosin-XVB",".",".",".",".","pfam00784","MyTH4","MyTH4 domain. Domain in myosin and kinesin tails, present twice in myosin-VIIa, and also present in 3 other myosins.",".",".",".",".","."]
["ENSRNOG00000007740",1,0.064330438,249,16.07590305,0.004001669,-7.965182551,{"v":3.06133e-54,"d":"3.06E-54"},{"v":1.04821e-53,"d":"1.05E-53"},"down","yes","Tacstd2","protein_coding","chr4:96707951-96709650:-","gi|82617596|ref|NP_001009540.2|",1416,0,"tumor-associated calcium signal transducer 2 precursor [Rattus norvegicus]","gi|82617595|ref|NM_001009540.2|",1700,0,"Rattus norvegicus tumor-associated calcium signal transducer 2 (Tacstd2), mRNA","Q6P9Z6",549,0,"Tumor-associated calcium signal transducer 2",".",".",".",".","pfam00086","Thyroglobulin_1","Thyroglobulin type-1 repeat. Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.","GO:0008150|biological_process;GO:0010633|negative regulation of epithelial cell migration;GO:0050678|regulation of epithelial cell proliferation;GO:0051497|negative regulation of stress fiber assembly;GO:0060675|ureteric bud morphogenesis;GO:0090191|negative regulation of branching involved in ureteric bud morphogenesis;GO:1900025|negative regulation of substrate adhesion-dependent cell spreading;GO:1900028|negative regulation of ruffle assembly;GO:2000146|negative regulation of cell motility;GO:2000738|positive regulation of stem cell differentiation;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0009925|basal plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016328|lateral plasma membrane;","GO:0003674|molecular_function;","K17288","TACSTD2; tumor-associated calcium signal transducer 2"]
["ENSRNOG00000016448",575,36.99000196,1222,78.8945925,0.468853451,-1.092791043,{"v":3.08211e-54,"d":"3.08E-54"},{"v":1.0547e-53,"d":"1.05E-53"},"down","yes","Eef2k","protein_coding","chr1:175393154-175455164:+","gi|6978795|ref|NP_037079.1|",3695,0,"eukaryotic elongation factor 2 kinase [Rattus norvegicus]","gi|1495778|emb|X96426.1|",4690,0,"R.norvegicus mRNA for skeletal muscle elongation factor-2 kinase","P70531",1408,0,"Eukaryotic elongation factor 2 kinase",".",".",".",".","pfam02816","Alpha_kinase","Alpha-kinase family. This family is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional kinases. The family contains myosin heavy chain kinases and Elongation Factor-2 kinase and a bifunctional ion channel. This family is known as the alpha-kinase family. The structure of the kinase domain revealed unexpected similarity to eukaryotic protein kinases in the catalytic core as well as to metabolic enzymes with ATP-grasp domains.","GO:0002931|response to ischemia;GO:0031952|regulation of protein autophosphorylation;GO:0032869|cellular response to insulin stimulus;GO:0043066|negative regulation of apoptotic process;GO:0045807|positive regulation of endocytosis;GO:0046777|protein autophosphorylation;GO:0051965|positive regulation of synapse assembly;GO:0061003|positive regulation of dendritic spine morphogenesis;GO:0071277|cellular response to calcium ion;GO:0071320|cellular response to cAMP;GO:0071454|cellular response to anoxia;GO:1990416|cellular response to brain-derived neurotrophic factor stimulus;GO:1990637|response to prolactin;","GO:0014069|postsynaptic density;GO:0043197|dendritic spine;","GO:0004686|elongation factor-2 kinase activity;GO:0005509|calcium ion binding;GO:0005516|calmodulin binding;GO:0005524|ATP binding;","K08292","EEF2K; elongation factor 2 kinase [EC:2.7.11.20]"]
["ENSRNOG00000001830",50,3.216521909,340,21.95103228,0.146531692,-2.770715366,{"v":3.12987e-54,"d":"3.13E-54"},{"v":1.0704E-53,"d":"1.07E-53"},"down","yes","Arntl2","protein_coding","chr4:179699502-179746949:+","gi|379135494|gb|AFC93435.1|",2986,0,"brain and muscle Arnt-like protein 2 variant d [Rattus norvegicus]","gi|297206837|ref|NM_133391.1|",1839,0,"Rattus norvegicus aryl hydrocarbon receptor nuclear translocator-like 2 (Arntl2), mRNA","Q2VPD4",946,0,"Aryl hydrocarbon receptor nuclear translocator-like protein 2",".",".",".",".","pfam14598","PAS_11","PAS domain. This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).","GO:0006357|regulation of transcription by RNA polymerase II;GO:0007623|circadian rhythm;GO:0042753|positive regulation of circadian rhythm;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0034751|aryl hydrocarbon receptor complex;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003700|DNA-binding transcription factor activity;GO:0046983|protein dimerization activity;GO:0070888|E-box binding;","K09099","ARNTL2, BMAL2; aryl hydrocarbon receptor nuclear translocator-like protein 2"]
["ENSRNOG00000003205",374,24.05958388,921,59.46147274,0.404624756,-1.305343506,{"v":3.47867e-54,"d":"3.48E-54"},{"v":1.18826E-53,"d":"1.19E-53"},"down","yes","Ldb2","protein_coding","chr14:66277085-66597778:+","gi|884884706|ref|XP_013002776.1|",1607,0,"PREDICTED: LIM domain-binding protein 2 isoform X4 [Cavia porcellus]","gi|672076384|ref|XM_008770202.1|",1605,0,"PREDICTED: Rattus norvegicus LIM domain binding 2 (Ldb2), transcript variant X4, mRNA","O55203",548,0,"LIM domain-binding protein 2",".",".",".",".","pfam01803","LIM_bind","LIM-domain binding protein. The LIM-domain binding protein, binds to the LIM domain pfam00412 of LIM homeodomain proteins which are transcriptional regulators of development. Nuclear LIM interactor (NLI) / LIM domain-binding protein 1 (LDB1) is located in the nuclei of neuronal cells during development, it is co-expressed with Isl1 in early motor neuron differentiation and has a suggested role in the Isl1 dependent development of motor neurons. It is suggested that these proteins act synergistically to enhance transcriptional efficiency by acting as co-factors for LIM homeodomain and Otx class transcription factors both of which have essential roles in development. The Drosophila protein Chip is required for segmentation and activity of a remote wing margin enhancer. Chip is a ubiquitous chromosomal factor required for normal expression of diverse genes at many stages of development. It is suggested that Chip cooperates with different LIM domain proteins and other factors to structurally support remote enhancer-promoter interactions.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001942|hair follicle development;GO:0007399|nervous system development;GO:0010669|epithelial structure maintenance;GO:0030334|regulation of cell migration;GO:0035019|somatic stem cell population maintenance;GO:0043549|regulation of kinase activity;GO:0044089|positive regulation of cellular component biogenesis;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005730|nucleolus;GO:0005886|plasma membrane;GO:0031252|cell leading edge;","GO:0003712|transcription coregulator activity;GO:0019899|enzyme binding;GO:0030274|LIM domain binding;","K24143","LDB2; LIM domain-binding protein 2"]
["ENSRNOG00000023778",145,9.327913537,536,34.60515678,0.269552703,-1.89136072,{"v":4.86415e-54,"d":"4.86E-54"},{"v":1.66053e-53,"d":"1.66E-53"},"down","yes","Gcnt2","protein_coding","chr17:23796859-23901611:-","gi|40849882|gb|AAR95653.1|",2028,0,"I-branching beta-1,6-acetylglucosaminyltransferase family polypeptide 2 [Rattus norvegicus]","gi|40849881|gb|AY435152.1|",3605,0,"Rattus norvegicus I-branching beta-1,6-acetylglucosaminyltransferase family polypeptide 2 (Ignt2) mRNA, complete cds","P97402",734,0,"N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase",".",".",".",".","pfam02485","Branch","Core-2/I-Branching enzyme. This is a family of two different beta-1,6-N-acetylglucosaminyltransferase enzymes, I-branching enzyme and core-2 branching enzyme. I-branching enzyme is responsible for the production of the blood group I-antigen during embryonic development. Core-2 branching enzyme forms crucial side-chain branches in O-glycans.","GO:0006486|protein glycosylation;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0008150|biological_process;GO:0008284|positive regulation of cell proliferation;GO:0010608|posttranscriptional regulation of gene expression;GO:0010718|positive regulation of epithelial to mesenchymal transition;GO:0010812|negative regulation of cell-substrate adhesion;GO:0030335|positive regulation of cell migration;GO:0034116|positive regulation of heterotypic cell-cell adhesion;GO:0036438|maintenance of lens transparency;GO:0051897|positive regulation of protein kinase B signaling;GO:0070374|positive regulation of ERK1 and ERK2 cascade;","GO:0000139|Golgi membrane;GO:0005575|cellular_component;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0008109|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity;GO:0008375|acetylglucosaminyltransferase activity;","K00742","GCNT2; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase [EC:2.4.1.150]"]
["ENSRNOG00000027357",586,37.69763678,1233,79.60477295,0.473560006,-1.078380849,{"v":1.39643E-53,"d":"1.40E-53"},{"v":4.7501e-53,"d":"4.75E-53"},"down","yes","Sox17","protein_coding","chr5:15016731-15022228:+","gi|157824128|ref|NP_001101372.1|",1738,0,"transcription factor SOX-17 [Rattus norvegicus]","gi|157824127|ref|NM_001107902.1|",2326,0,"Rattus norvegicus SRY box 17 (Sox17), mRNA","Q61473",640,0,"Transcription factor SOX-17","SPAC57A10.09c",56.2,2E-8,"COG5648","pfam12067","Sox_C_TAD","Sox C-terminal transactivation domain. This domain is found at the C-terminus of the Sox family of transcription factors. It is found associated with pfam00505. It binds to the Armadillo repeats (pfam00514) in Catenin beta-1 (CTNNB1), which is involved in transcriptional regulation. It functions as a transactivating domain (TAD).","GO:0001525|angiogenesis;GO:0001570|vasculogenesis;GO:0001656|metanephros development;GO:0001706|endoderm formation;GO:0001714|endodermal cell fate specification;GO:0001828|inner cell mass cellular morphogenesis;GO:0001947|heart looping;GO:0003142|cardiogenic plate morphogenesis;GO:0003143|embryonic heart tube morphogenesis;GO:0003151|outflow tract morphogenesis;GO:0003308|negative regulation of Wnt signaling pathway involved in heart development;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007283|spermatogenesis;GO:0007369|gastrulation;GO:0007492|endoderm development;GO:0007493|endodermal cell fate determination;GO:0007507|heart development;GO:0008150|biological_process;GO:0009653|anatomical structure morphogenesis;GO:0010628|positive regulation of gene expression;GO:0021903|rostrocaudal neural tube patterning;GO:0023019|signal transduction involved in regulation of gene expression;GO:0030154|cell differentiation;GO:0030178|negative regulation of Wnt signaling pathway;GO:0030308|negative regulation of cell growth;GO:0031648|protein destabilization;GO:0035050|embryonic heart tube development;GO:0042074|cell migration involved in gastrulation;GO:0045595|regulation of cell differentiation;GO:0045597|positive regulation of cell differentiation;GO:0045732|positive regulation of protein catabolic process;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0045995|regulation of embryonic development;GO:0048568|embryonic organ development;GO:0048617|embryonic foregut morphogenesis;GO:0048863|stem cell differentiation;GO:0048866|stem cell fate specification;GO:0050821|protein stabilization;GO:0060214|endocardium formation;GO:0060913|cardiac cell fate determination;GO:0060956|endocardial cell differentiation;GO:0061009|common bile duct development;GO:0061010|gall bladder development;GO:0061031|endodermal digestive tract morphogenesis;GO:0072091|regulation of stem cell proliferation;GO:0072189|ureter development;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:1990830|cellular response to leukemia inhibitory factor;GO:2000035|regulation of stem cell division;GO:2000043|regulation of cardiac cell fate specification;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0008013|beta-catenin binding;GO:0043565|sequence-specific DNA binding;","K04495","SOX17; transcription factor SOX17 (SOX group F)"]
["ENSRNOG00000005058",155,9.971217919,552,35.63814653,0.279790586,-1.837580671,{"v":1.54231e-53,"d":"1.54E-53"},{"v":5.24321e-53,"d":"5.24E-53"},"down","yes","Lpcat4","protein_coding","chr3:99044729-99052875:+","gi|157817376|ref|NP_001099964.1|",2443,0,"lysophospholipid acyltransferase LPCAT4 [Rattus norvegicus]","gi|157817375|ref|NM_001106494.1|",2488,0,"Rattus norvegicus lysophosphatidylcholine acyltransferase 4 (Lpcat4), mRNA","Q6NVG1",918,0,"Lysophospholipid acyltransferase LPCAT4","ECU10g0310",56.2,3e-07,"COG0204","pfam01553","Acyltransferase","Acyltransferase. This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.","GO:0006644|phospholipid metabolic process;GO:0036150|phosphatidylserine acyl-chain remodeling;GO:0036151|phosphatidylcholine acyl-chain remodeling;GO:0036152|phosphatidylethanolamine acyl-chain remodeling;","GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;","GO:0047166|1-alkenylglycerophosphoethanolamine O-acyltransferase activity;GO:0047184|1-acylglycerophosphocholine O-acyltransferase activity;GO:0047192|1-alkylglycerophosphocholine O-acetyltransferase activity;GO:0071617|lysophospholipid acyltransferase activity;","K13512","LPCAT4, AGPAT7; lysophospholipid acyltransferase [EC:2.3.1.23 2.3.1.-]"]
["ENSRNOG00000008615",16,1.029287011,248,16.01134119,0.064284871,-3.95937693,{"v":1.58307E-53,"d":"1.58E-53"},{"v":5.37859e-53,"d":"5.38E-53"},"down","yes","Mal2","protein_coding","chr7:85900453-85933429:+","gi|77157795|ref|NP_942081.2|",652,{"v":6e-76,"d":"6.00E-76"},"protein MAL2 [Rattus norvegicus]","gi|77157794|ref|NM_198786.2|",2776,0,"Rattus norvegicus mal, T-cell differentiation protein 2 (Mal2), mRNA","Q8BI08",249,{"v":4e-75,"d":"4.00E-75"},"Protein MAL2",".",".",".",".","pfam01284","MARVEL","Membrane-associating domain. MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.","GO:0042552|myelination;GO:0045056|transcytosis;","GO:0016021|integral component of membrane;GO:0030285|integral component of synaptic vesicle membrane;GO:0045121|membrane raft;GO:0098686|hippocampal mossy fiber to CA3 synapse;GO:0098978|glutamatergic synapse;","GO:0019911|structural constituent of myelin sheath;",".","."]
["ENSRNOG00000008313",75,4.824782864,393,25.37281084,0.190155631,-2.394747431,{"v":2.25394E-53,"d":"2.25E-53"},{"v":7.65335E-53,"d":"7.65E-53"},"down","yes","Hoxb3","protein_coding","chr10:81299357-81313107:+","gi|564373947|ref|XP_006247256.1|",1708,0,"PREDICTED: homeobox protein Hox-B3 isoform X1 [Rattus norvegicus]","gi|672068663|ref|XM_006247194.2|",2138,0,"PREDICTED: Rattus norvegicus homeo box B3 (Hoxb3), transcript variant X1, mRNA","P09026",640,0,"Homeobox protein Hox-B3",".",".",".",".","pfam13293","DUF4074","Domain of unknown function (DUF4074). This family is found at the C-terminal of Homeobox proteins in Metazoa.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001525|angiogenesis;GO:0002244|hematopoietic progenitor cell differentiation;GO:0006357|regulation of transcription by RNA polymerase II;GO:0009952|anterior/posterior pattern specification;GO:0021546|rhombomere development;GO:0021615|glossopharyngeal nerve morphogenesis;GO:0030878|thyroid gland development;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048704|embryonic skeletal system morphogenesis;GO:0050767|regulation of neurogenesis;GO:0051216|cartilage development;GO:0060216|definitive hemopoiesis;GO:0060324|face development;","GO:0005634|nucleus;GO:0005654|nucleoplasm;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;","K09303","HOX_3; homeobox protein HoxA/B/D3"]
["ENSRNOG00000029191",152,9.778226604,545,35.18621351,0.277899371,-1.847365526,{"v":2.97592e-53,"d":"2.98E-53"},{"v":1.00929E-52,"d":"1.01E-52"},"down","yes","ENSRNOG00000029191","protein_coding","chr2:231275640-231297278:+","gi|392339045|ref|XP_003753713.1|",3074,0,"PREDICTED: guanylate-binding protein 4 isoform X1 [Rattus norvegicus]","gi|672016381|ref|XM_003753665.3|",3367,0,"PREDICTED: Rattus norvegicus similar to guanylate binding protein family, member 6 (LOC685067), transcript variant X1, mRNA","Q61107",877,0,"Guanylate-binding protein 4",".",".",".",".","pfam02263","GBP","Guanylate-binding protein, N-terminal domain. Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.","GO:0044406|adhesion of symbiont to host;",".",".","K20899","GBP1_3_4_7; guanylate-binding protein 1/3/4/7"]
["ENSRNOG00000014573",8,0.514643505,224,14.46185656,0.035586268,-4.812535541,{"v":3.71684e-53,"d":"3.72E-53"},{"v":1.25907E-52,"d":"1.26E-52"},"down","yes","Ckmt1","protein_coding","chr3:108330705-108335758:+","gi|826307947|ref|XP_012504792.1|",2010,0,"PREDICTED: creatine kinase U-type, mitochondrial isoform X1 [Propithecus coquereli]","gi|672046796|ref|XM_006234830.2|",1231,0,"PREDICTED: Rattus norvegicus creatine kinase, mitochondrial 1B (Ckmt1b), transcript variant X1, mRNA","P30275",743,0,"Creatine kinase U-type, mitochondrial","SA0482",96.3,{"v":1e-20,"d":"1.00E-20"},"COG3869","pfam00217","ATP-gua_Ptrans","ATP:guanido phosphotransferase, C-terminal catalytic domain. The substrate binding site is located in the cleft between N and C-terminal domains, but most of the catalytic residues are found in the larger C-terminal domain.","GO:0001822|kidney development;GO:0007420|brain development;GO:0007519|skeletal muscle tissue development;GO:0016310|phosphorylation;GO:0021549|cerebellum development;GO:0032091|negative regulation of protein binding;GO:0043066|negative regulation of apoptotic process;GO:0046314|phosphocreatine biosynthetic process;GO:0048565|digestive tract development;","GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0043204|perikaryon;GO:0044289|contact site;","GO:0004111|creatine kinase activity;GO:0005524|ATP binding;GO:0016301|kinase activity;GO:0042802|identical protein binding;","K00933","E2.7.3.2; creatine kinase [EC:2.7.3.2]"]
["ENSRNOG00000002916",4,0.257321753,216,13.94536169,0.018452139,-5.760068122,{"v":6.9512e-53,"d":"6.95E-53"},{"v":2.35053e-52,"d":"2.35E-52"},"down","yes","Ca4","protein_coding","chr10:69827945-69836501:+","gi|149053720|gb|EDM05537.1|",1532,0,"carbonic anhydrase 4 [Rattus norvegicus]","gi|403048745|ref|NM_019174.3|",1266,0,"Rattus norvegicus carbonic anhydrase 4 (Car4), mRNA","P48284",585,0,"Carbonic anhydrase 4","BH0360",103,{"v":2e-24,"d":"2.00E-24"},"COG3338","pfam00194","Carb_anhydrase","Eukaryotic-type carbonic anhydrase.","GO:0006730|one-carbon metabolic process;GO:0009410|response to xenobiotic stimulus;GO:0015701|bicarbonate transport;GO:0048513|animal organ development;GO:0048545|response to steroid hormone;","GO:0005791|rough endoplasmic reticulum;GO:0005793|endoplasmic reticulum-Golgi intermediate compartment;GO:0005794|Golgi apparatus;GO:0005802|trans-Golgi network;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0016324|apical plasma membrane;GO:0016529|sarcoplasmic reticulum;GO:0030658|transport vesicle membrane;GO:0030667|secretory granule membrane;GO:0031362|anchored component of external side of plasma membrane;GO:0031526|brush border membrane;GO:0042383|sarcolemma;GO:0046658|anchored component of plasma membrane;GO:0048471|perinuclear region of cytoplasm;GO:0070062|extracellular exosome;","GO:0004089|carbonate dehydratase activity;GO:0008270|zinc ion binding;GO:0016836|hydro-lyase activity;","K18246","CA4; carbonic anhydrase 4 [EC:4.2.1.1]"]
["ENSRNOG00000024277",33,2.12290446,292,18.85206302,0.112608602,-3.150611059,{"v":7.68821e-53,"d":"7.69E-53"},{"v":2.59667e-52,"d":"2.60E-52"},"down","yes","Card11","protein_coding","chr12:13621087-13758112:+","gi|47847424|dbj|BAD21384.1|",5639,0,"mFLJ00120 protein [Mus musculus]","gi|672026525|ref|XM_008758980.1|",3888,0,"PREDICTED: Rattus norvegicus caspase recruitment domain family, member 11 (LOC100363332), transcript variant X1, mRNA","Q8CIS0",2140,0,"Caspase recruitment domain-containing protein 11",".",".",".",".","pfam00619","CARD","Caspase recruitment domain. Motif contained in proteins involved in apoptotic signaling. Predicted to possess a DEATH (pfam00531) domain-like fold.","GO:0007165|signal transduction;GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0008150|biological_process;GO:0030183|B cell differentiation;GO:0030890|positive regulation of B cell proliferation;GO:0031295|T cell costimulation;GO:0032743|positive regulation of interleukin-2 production;GO:0038202|TORC1 signaling;GO:0042100|B cell proliferation;GO:0042102|positive regulation of T cell proliferation;GO:0042110|T cell activation;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045061|thymic T cell selection;GO:0045577|regulation of B cell differentiation;GO:0045580|regulation of T cell differentiation;GO:0046649|lymphocyte activation;GO:0048872|homeostasis of number of cells;GO:0050776|regulation of immune response;GO:0050862|positive regulation of T cell receptor signaling pathway;GO:0050870|positive regulation of T cell activation;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051260|protein homooligomerization;","GO:0001772|immunological synapse;GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0032449|CBM complex;GO:0045121|membrane raft;","GO:0003674|molecular_function;GO:0043621|protein self-association;GO:0050700|CARD domain binding;","K07367","CARD11; caspase recruitment domain-containing protein 11"]
["ENSRNOG00000005386",337,21.67935767,854,55.13582815,0.393199094,-1.346668098,{"v":9.19222e-53,"d":"9.19E-53"},{"v":3.10281e-52,"d":"3.10E-52"},"down","yes","Kitlg","protein_coding","chr7:34896053-34977214:+","gi|33667068|ref|NP_068615.1|",1231,{"v":3E-152,"d":"3.00E-152"},"kit ligand isoform 1 precursor [Rattus norvegicus]","gi|394025760|ref|NM_021843.4|",5359,0,"Rattus norvegicus KIT ligand (Kitlg), transcript variant 1, mRNA","P21581",478,{"v":1E-153,"d":"1.00E-153"},"Kit ligand",".",".",".",".","pfam02404","SCF","Stem cell factor. Stem cell factor (SCF) is a homodimer involved in hematopoiesis. SCF binds to and activates the SCF receptor (SCFR), a receptor tyrosine kinase. The crystal structure of human SCF has been resolved and a potential receptor-binding site identified.","GO:0001541|ovarian follicle development;GO:0001755|neural crest cell migration;GO:0002687|positive regulation of leukocyte migration;GO:0002763|positive regulation of myeloid leukocyte differentiation;GO:0007155|cell adhesion;GO:0007165|signal transduction;GO:0008284|positive regulation of cell proliferation;GO:0008584|male gonad development;GO:0033026|negative regulation of mast cell apoptotic process;GO:0035162|embryonic hemopoiesis;GO:0035234|ectopic germ cell programmed cell death;GO:0043066|negative regulation of apoptotic process;GO:0043406|positive regulation of MAP kinase activity;GO:0045636|positive regulation of melanocyte differentiation;GO:0046579|positive regulation of Ras protein signal transduction;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0070668|positive regulation of mast cell proliferation;GO:0097192|extrinsic apoptotic signaling pathway in absence of ligand;GO:1902035|positive regulation of hematopoietic stem cell proliferation;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030027|lamellipodium;GO:0030175|filopodium;","GO:0005125|cytokine activity;GO:0005173|stem cell factor receptor binding;GO:0008083|growth factor activity;","K05461","KITLG; KIT ligand"]
["ENSRNOG00000014597",385,24.7672187,928,59.91340576,0.413383589,-1.274446979,{"v":1.1769e-52,"d":"1.18E-52"},{"v":3.9679e-52,"d":"3.97E-52"},"down","yes","Irs1","protein_coding","chr9:83548944-83606122:-","gi|149016256|gb|EDL75502.1|",5156,0,"insulin receptor substrate 1 [Rattus norvegicus]","gi|161086993|ref|NM_010570.4|",6958,0,"Mus musculus insulin receptor substrate 1 (Irs1), mRNA","P35570",1986,0,"Insulin receptor substrate 1",".",".",".",".","pfam02174","IRS","PTB domain (IRS-1 type).","GO:0002053|positive regulation of mesenchymal cell proliferation;GO:0007568|aging;GO:0008286|insulin receptor signaling pathway;GO:0010468|regulation of gene expression;GO:0010907|positive regulation of glucose metabolic process;GO:0014065|phosphatidylinositol 3-kinase signaling;GO:0014823|response to activity;GO:0016042|lipid catabolic process;GO:0030335|positive regulation of cell migration;GO:0030879|mammary gland development;GO:0031000|response to caffeine;GO:0032000|positive regulation of fatty acid beta-oxidation;GO:0032868|response to insulin;GO:0032869|cellular response to insulin stimulus;GO:0034504|protein localization to nucleus;GO:0042327|positive regulation of phosphorylation;GO:0043434|response to peptide hormone;GO:0043491|protein kinase B signaling;GO:0043552|positive regulation of phosphatidylinositol 3-kinase activity;GO:0045725|positive regulation of glycogen biosynthetic process;GO:0046326|positive regulation of glucose import;GO:0046627|negative regulation of insulin receptor signaling pathway;GO:0046628|positive regulation of insulin receptor signaling pathway;GO:0046676|negative regulation of insulin secretion;GO:0048009|insulin-like growth factor receptor signaling pathway;GO:0070094|positive regulation of glucagon secretion;GO:0071398|cellular response to fatty acid;GO:0071478|cellular response to radiation;GO:0090275|negative regulation of somatostatin secretion;GO:1904385|cellular response to angiotensin;GO:1990416|cellular response to brain-derived neurotrophic factor stimulus;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005899|insulin receptor complex;GO:0005901|caveola;GO:0036064|ciliary basal body;GO:0043231|intracellular membrane-bounded organelle;","GO:0001784|phosphotyrosine residue binding;GO:0005068|transmembrane receptor protein tyrosine kinase adaptor activity;GO:0005080|protein kinase C binding;GO:0005158|insulin receptor binding;GO:0005159|insulin-like growth factor receptor binding;GO:0005515|protein binding;GO:0019901|protein kinase binding;GO:0019904|protein domain specific binding;GO:0030159|receptor signaling complex scaffold activity;GO:0042169|SH2 domain binding;GO:0043548|phosphatidylinositol 3-kinase binding;GO:0044877|protein-containing complex binding;","K16172","IRS1; insulin receptor substrate 1"]
["ENSRNOG00000010841",37,2.380226213,301,19.43311976,0.122482969,-3.02934693,{"v":1.57401e-52,"d":"1.57E-52"},{"v":5.30052e-52,"d":"5.30E-52"},"down","yes","Col8a2","protein_coding","chr5:138585999-138612850:+","gi|148698346|gb|EDL30293.1|",821,{"v":8e-95,"d":"8.00E-95"},"procollagen, type VIII, alpha 2 [Mus musculus]","gi|672019925|ref|XM_006225530.2|",4251,0,"PREDICTED: Rattus norvegicus collagen, type VIII, alpha 2 (Col8a2), transcript variant X2, mRNA","P25318",324,{"v":8e-94,"d":"8.00E-94"},"Collagen alpha-2(VIII) chain",".",".",".",".","pfam00386","C1q","C1q domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.","GO:0030198|extracellular matrix organization;GO:0048593|camera-type eye morphogenesis;GO:0050673|epithelial cell proliferation;","GO:0005615|extracellular space;GO:0031012|extracellular matrix;","GO:0005201|extracellular matrix structural constituent;","K23455","COL8A; collagen type VIII alpha"]
["ENSRNOG00000027784",324,20.84306197,831,53.65090537,0.388494133,-1.364035283,{"v":2.25968e-52,"d":"2.26E-52"},{"v":7.60056e-52,"d":"7.60E-52"},"down","yes","Tsku","protein_coding","chr1:152656693-152672588:-","gi|564329813|ref|XP_006229821.1|",1714,0,"PREDICTED: tsukushin isoform X1 [Rattus norvegicus]","gi|672037839|ref|XM_006229760.2|",2442,0,"PREDICTED: Rattus norvegicus tsukushi, small leucine rich proteoglycan (Tsku), transcript variant X3, mRNA","Q6QMY6",663,0,"Tsukushin","alr0124_1",62.8,7e-09,"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0003431|growth plate cartilage chondrocyte development;GO:0008203|cholesterol metabolic process;GO:0010468|regulation of gene expression;GO:0010977|negative regulation of neuron projection development;GO:0021540|corpus callosum morphogenesis;GO:0021670|lateral ventricle development;GO:0021766|hippocampus development;GO:0021960|anterior commissure morphogenesis;GO:0030178|negative regulation of Wnt signaling pathway;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0032911|negative regulation of transforming growth factor beta1 production;GO:0033344|cholesterol efflux;GO:0042060|wound healing;GO:0042632|cholesterol homeostasis;GO:0042635|positive regulation of hair cycle;GO:0043010|camera-type eye development;GO:0060122|inner ear receptor cell stereocilium organization;GO:0061073|ciliary body morphogenesis;GO:0097009|energy homeostasis;GO:0098868|bone growth;GO:1904761|negative regulation of myofibroblast differentiation;","GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0031012|extracellular matrix;","GO:0050431|transforming growth factor beta binding;","K08130","TSKU; tsukushi"]
["ENSRNOG00000004699",323,20.77873153,829,53.52178165,0.388229444,-1.365018556,{"v":2.63165E-52,"d":"2.63E-52"},{"v":8.84127e-52,"d":"8.84E-52"},"down","yes","Fibin","protein_coding","chr3:96942406-96944676:-","gi|68163515|ref|NP_001020213.1|",1140,{"v":2e-148,"d":"2.00E-148"},"fin bud initiation factor homolog precursor [Rattus norvegicus]","gi|158262034|ref|NM_001025042.2|",2271,0,"Rattus norvegicus fin bud initiation factor homolog (zebrafish) (Fibin), mRNA","Q5U2T4",443,{"v":7e-150,"d":"7.00E-150"},"Fin bud initiation factor homolog",".",".",".",".","pfam14197","Cep57_CLD_2","Centrosome localisation domain of PPC89. The N-terminal region of the fission yeast spindle pole body protein PPC89 has low similarity to the human Cep57 protein. The CLD or centrosome localisation domain of Cep57 and PPC89 is found at the N-terminus. This region localizes to the centrosome internally to gamma-tubulin, suggesting that it is either on both centrioles or on a centromatrix component. This N-terminal region can also multimerize with the N-terminus of other Cep57 molecules. The C-terminal part, Family Cep57_MT_bd, pfam06657, is the microtubule-binding region of Cep57 and PPC89.","GO:0010042|response to manganese ion;GO:0070528|protein kinase C signaling;GO:0071548|response to dexamethasone;","GO:0005576|extracellular region;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;","GO:0042803|protein homodimerization activity;",".","."]
["ENSRNOG00000017484",83,5.339426369,405,26.14755316,0.204203672,-2.291919286,{"v":3.00833e-52,"d":"3.01E-52"},{"v":1.01008e-51,"d":"1.01E-51"},"down","yes","Gja5","protein_coding","chr2:184564475-184621952:+","gi|9506725|ref|NP_062153.1|",1836,0,"gap junction alpha-5 protein [Rattus norvegicus]","gi|672043500|ref|XM_008761328.1|",3027,0,"PREDICTED: Rattus norvegicus gap junction protein, alpha 5 (Gja5), transcript variant X1, mRNA","P28234",711,0,"Gap junction alpha-5 protein",".",".",".",".","pfam00029","Connexin","Connexin.","GO:0001501|skeletal system development;GO:0001525|angiogenesis;GO:0001568|blood vessel development;GO:0003071|renal system process involved in regulation of systemic arterial blood pressure;GO:0003073|regulation of systemic arterial blood pressure;GO:0003105|negative regulation of glomerular filtration;GO:0003151|outflow tract morphogenesis;GO:0003158|endothelium development;GO:0003161|cardiac conduction system development;GO:0003174|mitral valve development;GO:0003193|pulmonary valve formation;GO:0003281|ventricular septum development;GO:0003283|atrial septum development;GO:0003284|septum primum development;GO:0003294|atrial ventricular junction remodeling;GO:0006813|potassium ion transport;GO:0007267|cell-cell signaling;GO:0007507|heart development;GO:0010643|cell communication by chemical coupling;GO:0010644|cell communication by electrical coupling;GO:0010649|regulation of cell communication by electrical coupling;GO:0010652|positive regulation of cell communication by chemical coupling;GO:0016264|gap junction assembly;GO:0030326|embryonic limb morphogenesis;GO:0035050|embryonic heart tube development;GO:0035922|foramen ovale closure;GO:0036120|cellular response to platelet-derived growth factor stimulus;GO:0042311|vasodilation;GO:0045776|negative regulation of blood pressure;GO:0045907|positive regulation of vasoconstriction;GO:0048844|artery morphogenesis;GO:0055085|transmembrane transport;GO:0055117|regulation of cardiac muscle contraction;GO:0060307|regulation of ventricular cardiac muscle cell membrane repolarization;GO:0060371|regulation of atrial cardiac muscle cell membrane depolarization;GO:0060373|regulation of ventricular cardiac muscle cell membrane depolarization;GO:0060412|ventricular septum morphogenesis;GO:0060413|atrial septum morphogenesis;GO:0061337|cardiac conduction;GO:0086005|ventricular cardiac muscle cell action potential;GO:0086015|SA node cell action potential;GO:0086044|atrial cardiac muscle cell to AV node cell communication by electrical coupling;GO:0086053|AV node cell to bundle of His cell communication by electrical coupling;GO:0086054|bundle of His cell to Purkinje myocyte communication by electrical coupling;GO:0086064|cell communication by electrical coupling involved in cardiac conduction;GO:0086065|cell communication involved in cardiac conduction;GO:0086067|AV node cell to bundle of His cell communication;GO:0086091|regulation of heart rate by cardiac conduction;GO:0097746|regulation of blood vessel diameter;GO:0098904|regulation of AV node cell action potential;GO:0098905|regulation of bundle of His cell action potential;GO:0098906|regulation of Purkinje myocyte action potential;GO:0098910|regulation of atrial cardiac muscle cell action potential;GO:1900133|regulation of renin secretion into blood stream;GO:1900825|regulation of membrane depolarization during cardiac muscle cell action potential;GO:1990029|vasomotion;","GO:0005887|integral component of plasma membrane;GO:0005921|gap junction;GO:0005922|connexin complex;GO:0014704|intercalated disc;GO:0042995|cell projection;","GO:0005243|gap junction channel activity;GO:0055077|gap junction hemi-channel activity;GO:0071253|connexin binding;GO:0086075|gap junction channel activity involved in cardiac conduction electrical coupling;GO:0086076|gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling;GO:0086077|gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling;GO:0086078|gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling;GO:0097718|disordered domain specific binding;","K07614","GJA5, CX40; gap junction alpha-5 protein"]
["ENSRNOG00000025117",29,1.865582707,279,18.01275884,0.103570071,-3.271320936,{"v":3.19099E-52,"d":"3.19E-52"},{"v":1.07015E-51,"d":"1.07E-51"},"down","yes","Noxo1","protein_coding","chr10:13721473-13726061:+","gi|564370938|ref|XP_006246010.1|",1556,0,"PREDICTED: NADPH oxidase organizer 1 isoform X1 [Rattus norvegicus]","gi|672066855|ref|XM_008767566.1|",1330,0,"PREDICTED: Rattus norvegicus NADPH oxidase organizer 1 (Noxo1), transcript variant X1, mRNA","Q8VCM2",529,0,"NADPH oxidase organizer 1",".",".",".",".","pfam00018","SH3_1","SH3 domain. SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta barrel.","GO:0006801|superoxide metabolic process;GO:0022617|extracellular matrix disassembly;GO:0042554|superoxide anion generation;GO:0050790|regulation of catalytic activity;","GO:0005737|cytoplasm;GO:0043020|NADPH oxidase complex;","GO:0016176|superoxide-generating NADPH oxidase activator activity;GO:0019899|enzyme binding;GO:0035091|phosphatidylinositol binding;","K17934","NOXO1, SNX28; NADPH oxidase organizer 1"]
["ENSRNOG00000049471",193,12.41577457,613,39.57641997,0.313716465,-1.672466846,{"v":3.38099e-52,"d":"3.38E-52"},{"v":1.13254e-51,"d":"1.13E-51"},"down","yes","Steap3","protein_coding","chr13:31351954-31396519:-","gi|81883408|sp|Q5RKL5.1|STEA3_RAT",2367,0,"RecName: Full=Metalloreductase STEAP3; AltName: Full=Six-transmembrane epithelial antigen of prostate 3; AltName: Full=pHyde","gi|55715849|gb|BC085696.1|",2675,0,"Rattus norvegicus STEAP family member 3, mRNA (cDNA clone MGC:93147 IMAGE:7190374), complete cds","Q5RKL5",916,0,"Metalloreductase STEAP3","alr8074",78.6,{"v":4e-15,"d":"4.00E-15"},"COG2085","pfam03807","F420_oxidored","NADP oxidoreductase coenzyme F420-dependent.","GO:0006826|iron ion transport;GO:0006915|apoptotic process;GO:0009306|protein secretion;GO:0015677|copper ion import;GO:0033212|iron assimilation;GO:0043065|positive regulation of apoptotic process;GO:0055072|iron ion homeostasis;GO:1902167|positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:1990182|exosomal secretion;","GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005771|multivesicular body;GO:0005886|plasma membrane;GO:0010008|endosome membrane;GO:0016021|integral component of membrane;","GO:0000293|ferric-chelate reductase activity;GO:0008823|cupric reductase activity;GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0052851|ferric-chelate reductase (NADPH) activity;","K10142","STEAP3, TSAP6; metalloreductase STEAP3 [EC:1.16.1.-]"]
["ENSRNOG00000014505",8,0.514643505,220,14.20360912,0.036233291,-4.786540333,{"v":3.79512e-52,"d":"3.80E-52"},{"v":1.27052E-51,"d":"1.27E-51"},"down","yes","Pmfbp1","protein_coding","chr19:37458108-37507879:+","gi|672084711|ref|XP_006255636.2|",4332,0,"PREDICTED: polyamine-modulated factor 1-binding protein 1 isoform X4 [Rattus norvegicus]","gi|672084710|ref|XM_006255574.2|",3317,0,"PREDICTED: Rattus norvegicus polyamine modulated factor 1 binding protein 1 (Pmfbp1), transcript variant X3, mRNA","Q9Z221",1559,0,"Polyamine-modulated factor 1-binding protein 1",".",".",".",".","pfam01576","Myosin_tail_1","Myosin tail. The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.","GO:0007010|cytoskeleton organization;GO:0007283|spermatogenesis;","GO:0001520|outer dense fiber;GO:0005737|cytoplasm;GO:0097224|sperm connecting piece;",".","K23223","PMFBP1; polyamine-modulated factor 1-binding protein 1"]
["ENSRNOG00000018406",335,21.55069679,846,54.61933327,0.394561696,-1.341677187,{"v":5.3419e-52,"d":"5.34E-52"},{"v":1.78e-51,"d":"1.78E-51"},"down","yes","Wipf1","protein_coding","chr3:58314542-58372742:-","gi|60390706|sp|Q6IN36.2|WIPF1_RAT",994,{"v":7e-118,"d":"7.00E-118"},"RecName: Full=WAS/WASL-interacting protein family member 1; AltName: Full=Wiskott-Aldrich syndrome protein-interacting protein; Short=WASP-interacting protein","gi|48675857|ref|NM_057192.2|",3944,0,"Rattus norvegicus WAS/WASL interacting protein family, member 1 (Wipf1), mRNA","Q6IN36",387,{"v":2E-119,"d":"2.00E-119"},"WAS/WASL-interacting protein family member 1",".",".",".",".","pfam02205","WH2","WH2 motif. The WH2 motif (for Wiskott Aldrich syndrome homology region 2) has been shown in WASP and Scar1 (mammalian homologue) to be the region that interacts with actin.","GO:0008154|actin polymerization or depolymerization;GO:0030036|actin cytoskeleton organization;GO:0030048|actin filament-based movement;GO:0046827|positive regulation of protein export from nucleus;GO:0051707|response to other organism;","GO:0001726|ruffle;GO:0005884|actin filament;GO:0015629|actin cytoskeleton;GO:0031410|cytoplasmic vesicle;","GO:0003779|actin binding;GO:0005515|protein binding;GO:0017124|SH3 domain binding;","K19475","WIPF; WAS/WASL-interacting protein"]
["ENSRNOG00000039902",132,8.49161784,501,32.34549169,0.262528637,-1.929453293,{"v":6.00052e-52,"d":"6.00E-52"},{"v":1.9983e-51,"d":"2.00E-51"},"down","yes","Lbh","protein_coding","chr6:22568834-22593079:-","gi|672055562|ref|XP_008762755.1|",608,{"v":1e-75,"d":"1.00E-75"},"PREDICTED: protein LBH isoform X1 [Rattus norvegicus]","gi|201027422|ref|NM_001129880.2|",604,0,"Rattus norvegicus limb bud and heart development (Lbh), mRNA","Q9CX60",214,{"v":2e-69,"d":"2.00E-69"},"Protein LBH",".",".",".",".","pfam15317","Lbh","Cardiac transcription factor regulator, Developmental protein. The family of proteins are cardiac transcription regulators, named Lbh, short for Limb, bud and heart. They regulate embryological development in the heart. More specifically, in humans, they may act as transcriptional activators in MAPK signaling pathway to mediate cellular functions. This family of proteins is found in eukaryotes. Proteins in this family are typically between 92 and 116 amino acids in length.","GO:0010468|regulation of gene expression;GO:0030879|mammary gland development;GO:0033147|negative regulation of intracellular estrogen receptor signaling pathway;GO:0043408|regulation of MAPK cascade;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0060644|mammary gland epithelial cell differentiation;GO:1904674|positive regulation of somatic stem cell population maintenance;GO:1904677|positive regulation of somatic stem cell division;GO:2000103|positive regulation of mammary stem cell proliferation;GO:2000737|negative regulation of stem cell differentiation;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0032991|protein-containing complex;",".",".","."]
["ENSRNOG00000008810",626,40.2708543,1277,82.44549478,0.488454274,-1.033704582,{"v":7.58293E-52,"d":"7.58E-52"},{"v":2.52233E-51,"d":"2.52E-51"},"down","yes","Nsmf","protein_coding","chr3:7861872-7870614:+","gi|672044599|ref|XP_008759797.1|",2466,0,"PREDICTED: NMDA receptor synaptonuclear signaling and neuronal migration factor isoform X1 [Rattus norvegicus]","gi|672044598|ref|XM_008761575.1|",2822,0,"PREDICTED: Rattus norvegicus NMDA receptor synaptonuclear signaling and neuronal migration factor (Nsmf), transcript variant X1, mRNA","Q9EPI6",944,0,"NMDA receptor synaptonuclear signaling and neuronal migration factor",".",".",".",".","pfam05110","AF-4","AF-4 proto-oncoprotein. This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.","GO:0008150|biological_process;GO:0035307|positive regulation of protein dephosphorylation;GO:0043523|regulation of neuron apoptotic process;GO:0048168|regulation of neuronal synaptic plasticity;GO:0048814|regulation of dendrite morphogenesis;GO:0071230|cellular response to amino acid stimulus;GO:0071257|cellular response to electrical stimulus;GO:0071371|cellular response to gonadotropin stimulus;GO:0099527|postsynapse to nucleus signaling pathway;GO:2001222|regulation of neuron migration;GO:2001224|positive regulation of neuron migration;","GO:0000791|euchromatin;GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005635|nuclear envelope;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0016363|nuclear matrix;GO:0030425|dendrite;GO:0030863|cortical cytoskeleton;GO:0031965|nuclear membrane;GO:0043005|neuron projection;GO:0043197|dendritic spine;GO:0043204|perikaryon;GO:0045202|synapse;GO:0097440|apical dendrite;GO:0098794|postsynapse;GO:0098978|glutamatergic synapse;","GO:0003674|molecular_function;GO:0005515|protein binding;GO:0048306|calcium-dependent protein binding;","K23844","NSMF; NMDA receptor synaptonuclear signaling and neuronal migration factor"]
["ENSRNOG00000007377",553,35.57473232,1170,75.5373758,0.470955364,-1.086337764,{"v":1.58742e-51,"d":"1.59E-51"},{"v":5.26189E-51,"d":"5.26E-51"},"down","yes","Slit3","protein_coding","chr10:19571684-20156634:+","gi|13786142|ref|NP_112611.1|",7752,0,"slit homolog 3 protein precursor [Rattus norvegicus]","gi|13786141|ref|NM_031321.1|",5177,0,"Rattus norvegicus slit guidance ligand 3 (Slit3), mRNA","O88280",2984,0,"Slit homolog 3 protein","alr0124_1",74.3,{"v":1e-12,"d":"1.00E-12"},"COG4886","pfam02210","Laminin_G_2","Laminin G domain. This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.","GO:0003180|aortic valve morphogenesis;GO:0003181|atrioventricular valve morphogenesis;GO:0007411|axon guidance;GO:0007420|brain development;GO:0008285|negative regulation of cell proliferation;GO:0009887|animal organ morphogenesis;GO:0010629|negative regulation of gene expression;GO:0021510|spinal cord development;GO:0030308|negative regulation of cell growth;GO:0032870|cellular response to hormone stimulus;GO:0035385|Roundabout signaling pathway;GO:0048846|axon extension involved in axon guidance;GO:0050919|negative chemotaxis;GO:0051414|response to cortisol;GO:0060412|ventricular septum morphogenesis;GO:0061364|apoptotic process involved in luteolysis;GO:0070100|negative regulation of chemokine-mediated signaling pathway;","GO:0005615|extracellular space;GO:0005739|mitochondrion;GO:0016020|membrane;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;GO:0008201|heparin binding;GO:0048495|Roundabout binding;","K06850","SLIT3; slit 3"]
["ENSRNOG00000004680",15,0.964956573,237,15.30116074,0.063064273,-3.987033273,{"v":1.9022e-51,"d":"1.90E-51"},{"v":6.30165e-51,"d":"6.30E-51"},"down","yes","Kif5c","protein_coding","chr3:34032105-34182413:+","gi|26006171|dbj|BAC41428.1|",4737,0,"mKIAA0531 protein [Mus musculus]","gi|157819776|ref|NM_001107730.1|",3702,0,"Rattus norvegicus kinesin family member 5C (Kif5c), mRNA","P28738",1778,0,"Kinesin heavy chain isoform 5C","SPAC1834.07",316,{"v":1e-93,"d":"1.00E-93"},"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0007018|microtubule-based movement;GO:0007411|axon guidance;GO:0008045|motor neuron axon guidance;GO:0030705|cytoskeleton-dependent intracellular transport;GO:0046034|ATP metabolic process;GO:0048489|synaptic vesicle transport;GO:0051028|mRNA transport;GO:0098963|dendritic transport of messenger ribonucleoprotein complex;GO:0098964|anterograde dendritic transport of messenger ribonucleoprotein complex;GO:0098971|anterograde dendritic transport of neurotransmitter receptor complex;GO:0099641|anterograde axonal protein transport;","GO:0005737|cytoplasm;GO:0005871|kinesin complex;GO:0005874|microtubule;GO:0030425|dendrite;GO:0032839|dendrite cytoplasm;GO:0035253|ciliary rootlet;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0044295|axonal growth cone;GO:0150034|distal axon;GO:1904115|axon cytoplasm;","GO:0003777|microtubule motor activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0008017|microtubule binding;GO:0008574|ATP-dependent microtubule motor activity, plus-end-directed;GO:0016887|ATPase activity;GO:0034190|apolipoprotein receptor binding;","K10396","KIF5; kinesin family member 5"]
["ENSRNOG00000053200",166,10.67885274,561,36.21920327,0.294839526,-1.761998149,{"v":1.98731e-51,"d":"1.99E-51"},{"v":6.57978e-51,"d":"6.58E-51"},"down","yes","Dock10","protein_coding","chr9:81843604-82101525:-","gi|392342442|ref|XP_003754589.1|",11191,0,"PREDICTED: dedicator of cytokinesis protein 10 isoform X13 [Rattus norvegicus]","gi|672024204|ref|XM_003754541.3|",7709,0,"PREDICTED: Rattus norvegicus dedicator of cytokinesis 10 (Dock10), transcript variant X13, mRNA","Q8BZN6",4110,0,"Dedicator of cytokinesis protein 10",".",".",".",".","pfam06920","Ded_cyto","Dedicator of cytokinesis. This family represents a conserved region approximately 200 residues long within a number of eukaryotic dedicator of cytokinesis proteins. These are potential guanine nucleotide exchange factors, which activate some small GTPases by exchanging bound GDP for free GTP.","GO:0001782|B cell homeostasis;GO:0002315|marginal zone B cell differentiation;GO:0030334|regulation of cell migration;GO:0043547|positive regulation of GTPase activity;GO:0060997|dendritic spine morphogenesis;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0043197|dendritic spine;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0031267|small GTPase binding;","K21853","DOCK9_10_11; dedicator of cytokinesis protein 9/10/11"]
["ENSRNOG00000036703",183,11.77247019,591,38.15605906,0.308534751,-1.696495101,{"v":2.22016e-51,"d":"2.22E-51"},{"v":7.34647e-51,"d":"7.35E-51"},"down","yes","Itgax","protein_coding","chr1:182719609-182740698:+","gi|293356227|ref|XP_574569.3|",6104,0,"PREDICTED: integrin alpha-X isoform X1 [Rattus norvegicus]","gi|672038695|ref|XM_574569.6|",4444,0,"PREDICTED: Rattus norvegicus integrin, alpha X (Itgax), transcript variant X1, mRNA","Q9QXH4",2026,0,"Integrin alpha-X",".",".",".",".","pfam08441","Integrin_alpha2","Integrin alpha. This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.","GO:0007229|integrin-mediated signaling pathway;GO:0008284|positive regulation of cell proliferation;GO:0010628|positive regulation of gene expression;GO:0030335|positive regulation of cell migration;GO:0031643|positive regulation of myelination;GO:0034113|heterotypic cell-cell adhesion;GO:0045766|positive regulation of angiogenesis;GO:0051607|defense response to virus;GO:1905956|positive regulation of endothelial tube morphogenesis;","GO:0008305|integrin complex;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;","GO:0030971|receptor tyrosine kinase binding;GO:0046872|metal ion binding;","K06462","ITGAX, CD11c; integrin alpha X"]
["ENSRNOG00000015133",616,39.62754992,1257,81.15425759,0.488299087,-1.034163013,{"v":4.24598e-51,"d":"4.25E-51"},{"v":1.40012e-50,"d":"1.40E-50"},"down","yes","Kmt2a","protein_coding","chr8:45118814-45193181:-","gi|672061705|ref|XP_008764401.1|",16272,0,"PREDICTED: histone-lysine N-methyltransferase 2A isoform X2, partial [Rattus norvegicus]","gi|672061704|ref|XM_008766179.1|",14301,0,"PREDICTED: Rattus norvegicus lysine (K)-specific methyltransferase 2A (Kmt2a), transcript variant X2, partial mRNA","P55200",4463,0,"Histone-lysine N-methyltransferase 2A","SPCC306.04c",164,{"v":2e-39,"d":"2.00E-39"},"COG2940","pfam00856","SET","SET domain. SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.","GO:0006306|DNA methylation;GO:0008285|negative regulation of cell proliferation;GO:0008542|visual learning;GO:0009416|response to light stimulus;GO:0009791|post-embryonic development;GO:0009952|anterior/posterior pattern specification;GO:0010468|regulation of gene expression;GO:0018026|peptidyl-lysine monomethylation;GO:0032411|positive regulation of transporter activity;GO:0032922|circadian regulation of gene expression;GO:0035162|embryonic hemopoiesis;GO:0035640|exploration behavior;GO:0035864|response to potassium ion;GO:0043984|histone H4-K16 acetylation;GO:0044648|histone H3-K4 dimethylation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048172|regulation of short-term neuronal synaptic plasticity;GO:0048536|spleen development;GO:0048873|homeostasis of number of cells within a tissue;GO:0050890|cognition;GO:0051568|histone H3-K4 methylation;GO:0051569|regulation of histone H3-K4 methylation;GO:0051571|positive regulation of histone H3-K4 methylation;GO:0051899|membrane depolarization;GO:0060216|definitive hemopoiesis;GO:0065003|protein-containing complex assembly;GO:0071440|regulation of histone H3-K14 acetylation;GO:0080182|histone H3-K4 trimethylation;GO:0097692|histone H3-K4 monomethylation;GO:1901674|regulation of histone H3-K27 acetylation;GO:1905642|negative regulation of DNA methylation;GO:2000615|regulation of histone H3-K9 acetylation;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0035097|histone methyltransferase complex;GO:0071339|MLL1 complex;","GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0008270|zinc ion binding;GO:0042800|histone methyltransferase activity (H3-K4 specific);GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0045322|unmethylated CpG binding;GO:0070577|lysine-acetylated histone binding;","K09186","MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1 [EC:2.1.1.354]"]
["ENSRNOG00000020770",121,7.78398302,475,30.66688334,0.25382374,-1.978101085,{"v":6.1469e-51,"d":"6.15E-51"},{"v":2.02229e-50,"d":"2.02E-50"},"down","yes","Arl4d","protein_coding","chr10:86595661-86602836:+","gi|13384792|ref|NP_079680.1|",990,{"v":3E-124,"d":"3.00E-124"},"ADP-ribosylation factor-like protein 4D [Mus musculus]","gi|157817377|ref|NM_001107052.1|",1375,0,"Rattus norvegicus ADP-ribosylation factor like GTPase 4D (Arl4d), mRNA","Q99PE9",385,{"v":8e-126,"d":"8.00E-126"},"ADP-ribosylation factor-like protein 4D",".",".",".",".","pfam00025","Arf","ADP-ribosylation factor family. Pfam combines a number of different Prosite families together","GO:0006886|intracellular protein transport;GO:0016192|vesicle-mediated transport;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;","GO:0003924|GTPase activity;GO:0005525|GTP binding;","K07945","ARL4; ADP-ribosylation factor-like protein 4"]
["ENSRNOG00000028043",2,0.128660876,213,13.75167611,0.009356014,-6.73989024,{"v":6.53012e-51,"d":"6.53E-51"},{"v":2.14589e-50,"d":"2.15E-50"},"down","yes","Cxcl3","protein_coding","chr14:17270146-17289511:-","gi|564383032|ref|XP_006250783.1|",393,{"v":4e-43,"d":"4.00E-43"},"PREDICTED: C-X-C motif chemokine 3 isoform X1 [Rattus norvegicus]","gi|672075638|ref|XM_006250721.2|",883,0,"PREDICTED: Rattus norvegicus chemokine (C-X-C motif) ligand 3 (Cxcl3), transcript variant X1, mRNA","Q10746",155,{"v":1e-44,"d":"1.00E-44"},"C-X-C motif chemokine 3",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0006954|inflammatory response;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0030593|neutrophil chemotaxis;GO:0031640|killing of cells of other organism;GO:0032496|response to lipopolysaccharide;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098|chemokine-mediated signaling pathway;GO:0071222|cellular response to lipopolysaccharide;","GO:0005615|extracellular space;","GO:0008009|chemokine activity;GO:0045236|CXCR chemokine receptor binding;","K05505","CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3"]
["ENSRNOG00000046601",13,0.836295696,229,14.78466586,0.056565073,-4.143944689,{"v":7.04627e-51,"d":"7.05E-51"},{"v":2.31417e-50,"d":"2.31E-50"},"down","yes","Unc5cl","protein_coding","chr9:12528246-12542233:-","gi|564367086|ref|XP_006244483.1|",2759,0,"PREDICTED: UNC5C-like protein isoform X1 [Rattus norvegicus]","gi|672064254|ref|XM_006244422.2|",2663,0,"PREDICTED: Rattus norvegicus unc-5 homolog C (C. elegans)-like (Unc5cl), transcript variant X3, mRNA","Q6R653",1003,0,"UNC5C-like protein",".",".",".",".","pfam00791","ZU5","ZU5 domain. Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.","GO:0006508|proteolysis;GO:0038007|netrin-activated signaling pathway;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0046330|positive regulation of JNK cascade;","GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0005042|netrin receptor activity;GO:0008233|peptidase activity;",".","."]
["ENSRNOG00000005917",592,38.08361941,1221,78.83003064,0.483110549,-1.049574739,{"v":7.32604e-51,"d":"7.33E-51"},{"v":2.40329E-50,"d":"2.40E-50"},"down","yes","Pawr","protein_coding","chr7:43645084-43725028:+","gi|564359180|ref|XP_006241379.1|",1582,0,"PREDICTED: PRKC apoptosis WT1 regulator protein isoform X1 [Rattus norvegicus]","gi|672058658|ref|XM_006241317.2|",2173,0,"PREDICTED: Rattus norvegicus PRKC, apoptosis, WT1, regulator (Pawr), transcript variant X1, mRNA","Q62627",612,0,"PRKC apoptosis WT1 regulator protein",".",".",".",".","pfam05911","DUF869","Plant protein of unknown function (DUF869). This family consists of a number of sequences found in Arabidopsis thaliana, Oryza sativa and Lycopersicon esculentum (Tomato). The function of this family is unknown.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006915|apoptotic process;GO:0009611|response to wounding;GO:0010040|response to iron(II) ion;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0030889|negative regulation of B cell proliferation;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0032516|positive regulation of phosphoprotein phosphatase activity;GO:0042130|negative regulation of T cell proliferation;GO:0042986|positive regulation of amyloid precursor protein biosynthetic process;GO:0043065|positive regulation of apoptotic process;GO:0043525|positive regulation of neuron apoptotic process;GO:0045760|positive regulation of action potential;GO:0048147|negative regulation of fibroblast proliferation;GO:0050860|negative regulation of T cell receptor signaling pathway;GO:0050965|detection of temperature stimulus involved in sensory perception of pain;GO:0050966|detection of mechanical stimulus involved in sensory perception of pain;GO:0051017|actin filament bundle assembly;GO:0060450|positive regulation of hindgut contraction;GO:0071306|cellular response to vitamin E;GO:0071347|cellular response to interleukin-1;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0071392|cellular response to estradiol stimulus;GO:0090281|negative regulation of calcium ion import;GO:0097190|apoptotic signaling pathway;GO:0097202|activation of cysteine-type endopeptidase activity;GO:0098703|calcium ion import across plasma membrane;GO:1901082|positive regulation of relaxation of smooth muscle;GO:1901300|positive regulation of hydrogen peroxide-mediated programmed cell death;GO:1903238|positive regulation of leukocyte tethering or rolling;GO:1904457|positive regulation of neuronal action potential;GO:2000391|positive regulation of neutrophil extravasation;GO:2000774|positive regulation of cellular senescence;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0015629|actin cytoskeleton;GO:0030424|axon;GO:0043005|neuron projection;GO:0043025|neuronal cell body;","GO:0003779|actin binding;GO:0005080|protein kinase C binding;GO:0005515|protein binding;GO:0008157|protein phosphatase 1 binding;GO:0019899|enzyme binding;GO:0043522|leucine zipper domain binding;",".","."]
["ENSRNOG00000063720",10,0.643304382,220,14.20360912,0.045291614,-4.464612238,{"v":8.99399e-51,"d":"8.99E-51"},{"v":2.94707e-50,"d":"2.95E-50"},"down","yes","ENSRNOG00000063720","lncRNA","chr6:44003036-44007070:-",".",".",".",".","gi|880946383|ref|XM_013121973.1|",2344,0,"PREDICTED: Mesocricetus auratus SRY (sex determining region Y)-box 11 (Sox11), mRNA",".",".",".",".",".",".",".",".","pfam10325","7TM_GPCR_Srz","Serpentine type 7TM GPCR chemoreceptor Srz. Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srz is a solo families amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srz appear to be under strong adaptive evolutionary pressure.",".",".",".",".","."]
["ENSRNOG00000045560",68,4.374469797,366,23.62964063,0.185126379,-2.433417616,{"v":9.84295e-51,"d":"9.84E-51"},{"v":3.21971e-50,"d":"3.22E-50"},"down","yes","Gvin1","protein_coding","chr1:160277126-160306331:-","gi|109462622|ref|XP_001075550.1|",12947,0,"PREDICTED: interferon-induced very large GTPase 1-like isoform X1 [Rattus norvegicus]","gi|672014119|ref|XM_001075550.3|",7833,0,"PREDICTED: Rattus norvegicus similar to very large inducible GTPase 1 isoform A (LOC499229), transcript variant X1, mRNA","Q80SU7",4170,0,"Interferon-induced very large GTPase 1",".",".",".",".","pfam05879","RHD3","Root hair defective 3 GTP-binding protein (RHD3). This family consists of several eukaryotic root hair defective 3 like GTP-binding proteins. It has been speculated that the RHD3 protein is a member of a novel class of GTP-binding proteins that is widespread in eukaryotes and required for regulated cell enlargement. The family also contains the homologous yeast synthetic enhancement of YOP1 (SEY1) protein which is involved in membrane trafficking.",".","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0005525|GTP binding;",".","."]
["ENSRNOG00000020598",137,8.813270031,504,32.53917727,0.270851041,-1.88442846,{"v":1.11783E-50,"d":"1.12E-50"},{"v":3.64815E-50,"d":"3.65E-50"},"down","yes","Kcnk6","protein_coding","chr1:84525590-84534677:-","gi|9971949|gb|AAG10508.1|AF281304_1",1289,{"v":2e-168,"d":"2.00E-168"},"2P domain K+ channel TWIK-2 [Rattus norvegicus]","gi|672035966|ref|XM_003748812.3|",2175,0,"PREDICTED: Rattus norvegicus potassium channel subfamily K member 6-like (LOC100909725), mRNA","Q9Y257",409,{"v":1E-134,"d":"1.00E-134"},"Potassium channel subfamily K member 6","YJL093c",53.1,3e-06,"COG1226","pfam07885","Ion_trans_2","Ion channel. This family includes the two membrane helix type ion channels found in bacteria.","GO:0003073|regulation of systemic arterial blood pressure;GO:0003085|negative regulation of systemic arterial blood pressure;GO:0030322|stabilization of membrane potential;GO:0060075|regulation of resting membrane potential;GO:0071805|potassium ion transmembrane transport;","GO:0005887|integral component of plasma membrane;","GO:0005267|potassium channel activity;GO:0022841|potassium ion leak channel activity;","K04917","KCNK6, K2P6.1; potassium channel subfamily K member 6"]
["ENSRNOG00000056184",14,0.900626135,231,14.91378958,0.060388819,-4.049574739,{"v":1.19319E-50,"d":"1.19E-50"},{"v":3.89189e-50,"d":"3.89E-50"},"down","yes","Lrp2","protein_coding","chr3:54189308-54346708:-","gi|149022162|gb|EDL79056.1|",23985,0,"rCG26871, isoform CRA_a [Rattus norvegicus]","gi|13562117|ref|NM_030827.1|",15198,0,"Rattus norvegicus LDL receptor related protein 2 (Lrp2), mRNA","P98158",9238,0,"Low-density lipoprotein receptor-related protein 2",".",".",".",".","pfam00057","Ldl_recept_a","Low-density lipoprotein receptor domain class A.","GO:0001822|kidney development;GO:0001843|neural tube closure;GO:0003139|secondary heart field specification;GO:0003148|outflow tract septum morphogenesis;GO:0003223|ventricular compact myocardium morphogenesis;GO:0003281|ventricular septum development;GO:0006766|vitamin metabolic process;GO:0006897|endocytosis;GO:0006898|receptor-mediated endocytosis;GO:0007507|heart development;GO:0007568|aging;GO:0007605|sensory perception of sound;GO:0008283|cell proliferation;GO:0008584|male gonad development;GO:0009410|response to xenobiotic stimulus;GO:0010165|response to X-ray;GO:0010951|negative regulation of endopeptidase activity;GO:0015031|protein transport;GO:0016197|endosomal transport;GO:0020028|endocytic hemoglobin import;GO:0030001|metal ion transport;GO:0030514|negative regulation of BMP signaling pathway;GO:0030900|forebrain development;GO:0031100|animal organ regeneration;GO:0032526|response to retinoic acid;GO:0033280|response to vitamin D;GO:0035904|aorta development;GO:0043066|negative regulation of apoptotic process;GO:0044321|response to leptin;GO:0045056|transcytosis;GO:0045807|positive regulation of endocytosis;GO:0046879|hormone secretion;GO:0050769|positive regulation of neurogenesis;GO:0051897|positive regulation of protein kinase B signaling;GO:0060068|vagina development;GO:0060976|coronary vasculature development;GO:0060982|coronary artery morphogenesis;GO:0061156|pulmonary artery morphogenesis;GO:0061642|chemoattraction of axon;GO:0070447|positive regulation of oligodendrocyte progenitor proliferation;GO:0071363|cellular response to growth factor stimulus;GO:0097242|amyloid-beta clearance;GO:0140058|neuron projection arborization;GO:0140077|positive regulation of lipoprotein transport;GO:1904447|folate import across plasma membrane;GO:1905167|positive regulation of lysosomal protein catabolic process;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005903|brush border;GO:0005905|clathrin-coated pit;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0030139|endocytic vesicle;GO:0030424|axon;GO:0030425|dendrite;GO:0031526|brush border membrane;GO:0031904|endosome lumen;GO:0032991|protein-containing complex;GO:0043235|receptor complex;GO:0044295|axonal growth cone;GO:0045121|membrane raft;GO:0045177|apical part of cell;","GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0016922|nuclear receptor binding;GO:0017124|SH3 domain binding;GO:0030165|PDZ domain binding;GO:0030492|hemoglobin binding;GO:0031994|insulin-like growth factor I binding;GO:0038023|signaling receptor activity;GO:0042562|hormone binding;GO:0044877|protein-containing complex binding;GO:0050750|low-density lipoprotein particle receptor binding;GO:0051087|chaperone binding;","K06233","LRP2; low density lipoprotein-related protein 2"]
["ENSRNOG00000014357",114,7.333669953,460,29.69845544,0.246937756,-2.017780656,{"v":1.22602e-50,"d":"1.23E-50"},{"v":3.99669e-50,"d":"4.00E-50"},"down","yes","Gja4","protein_coding","chr5:139633287-139635925:-","gi|11067369|ref|NP_067686.1|",1627,0,"gap junction alpha-4 protein [Rattus norvegicus]","gi|51036648|ref|NM_021654.2|",1590,0,"Rattus norvegicus gap junction protein, alpha 4 (Gja4), mRNA","Q03190",631,0,"Gap junction alpha-4 protein",".",".",".",".","pfam00029","Connexin","Connexin.","GO:0001568|blood vessel development;GO:0003158|endothelium development;GO:0006816|calcium ion transport;GO:0007154|cell communication;GO:0007267|cell-cell signaling;GO:0048265|response to pain;GO:0055085|transmembrane transport;","GO:0005921|gap junction;GO:0005922|connexin complex;GO:0016021|integral component of membrane;","GO:0005243|gap junction channel activity;","K07613","GJA4, CX37; gap junction alpha-4 protein"]
["ENSRNOG00000054251",178,11.450818,578,37.31675488,0.306854603,-1.704372871,{"v":1.316e-50,"d":"1.32E-50"},{"v":4.28757e-50,"d":"4.29E-50"},"down","yes","Clec7a","protein_coding","chr4:162902732-162913897:-","gi|187469451|gb|AAI66774.1|",1303,{"v":1e-171,"d":"1.00E-171"},"Clec7a protein [Rattus norvegicus]","gi|290563187|ref|NM_001173386.1|",2426,0,"Rattus norvegicus C-type lectin domain family 7, member A (Clec7a), mRNA","Q6QLQ4",399,{"v":1e-131,"d":"1.00E-131"},"C-type lectin domain family 7 member A",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0001879|detection of yeast;GO:0002223|stimulatory C-type lectin receptor signaling pathway;GO:0002366|leukocyte activation involved in immune response;GO:0002732|positive regulation of dendritic cell cytokine production;GO:0006910|phagocytosis, recognition;GO:0008037|cell recognition;GO:0008284|positive regulation of cell proliferation;GO:0010628|positive regulation of gene expression;GO:0016046|detection of fungus;GO:0030335|positive regulation of cell migration;GO:0031334|positive regulation of protein complex assembly;GO:0032491|detection of molecule of fungal origin;GO:0032729|positive regulation of interferon-gamma production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032733|positive regulation of interleukin-10 production;GO:0032735|positive regulation of interleukin-12 production;GO:0032743|positive regulation of interleukin-2 production;GO:0032747|positive regulation of interleukin-23 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032874|positive regulation of stress-activated MAPK cascade;GO:0032930|positive regulation of superoxide anion generation;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043280|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050766|positive regulation of phagocytosis;GO:0050850|positive regulation of calcium-mediated signaling;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051251|positive regulation of lymphocyte activation;GO:0051712|positive regulation of killing of cells of other organism;GO:0060267|positive regulation of respiratory burst;GO:0061760|antifungal innate immune response;GO:0070884|regulation of calcineurin-NFAT signaling cascade;GO:0071226|cellular response to molecule of fungal origin;GO:0071639|positive regulation of monocyte chemotactic protein-1 production;GO:0090303|positive regulation of wound healing;GO:1900017|positive regulation of cytokine production involved in inflammatory response;GO:1903431|positive regulation of cell maturation;GO:2000318|positive regulation of T-helper 17 type immune response;","GO:0005737|cytoplasm;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0001872|(1->3)-beta-D-glucan binding;GO:0030246|carbohydrate binding;GO:0038187|pattern recognition receptor activity;GO:0042802|identical protein binding;","K10074","CLEC7A, DECTIN1, CD369; C-type lectin domain family 7 member A"]
["ENSRNOG00000038916",125,8.041304773,481,31.05425449,0.258943739,-1.949289418,{"v":1.32457e-50,"d":"1.32E-50"},{"v":4.31302e-50,"d":"4.31E-50"},"down","yes","Dram1","protein_coding","chr7:22742849-22776765:-","gi|290677861|ref|NP_001166898.1|",1255,{"v":4e-164,"d":"4.00E-164"},"DNA damage-regulated autophagy modulator protein 1 [Rattus norvegicus]","gi|290677860|ref|NM_001173427.1|",2080,0,"Rattus norvegicus DNA-damage regulated autophagy modulator 1 (Dram1), mRNA","Q9DC58",482,{"v":2e-163,"d":"2.00E-163"},"DNA damage-regulated autophagy modulator protein 1",".",".",".",".","pfam10277","Frag1","Frag1/DRAM/Sfk1 family. This family includes Frag1, DRAM and Sfk1 proteins. Frag1 (FGF receptor activating protein 1) is a protein that is conserved from fungi to humans. There are four potential iso-prenylation sites throughout the peptide, viz CILW, CIIW and CIGL. Frag1 is a membrane-spanning protein that is ubiquitously expressed in adult tissues suggesting an important cellular function. Dram is a family of proteins conserved from nematodes to humans with six hydrophobic transmembrane regions and an Endoplasmic Reticulum signal peptide. It is a lysosomal protein that induces macro-autophagy as an effector of p53-mediated death, where p53 is the tumor-suppressor gene that is frequently mutated in cancer. Expression of Dram is stress-induced. This region is also part of a family of small plasma membrane proteins, referred to as Sfk1, that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, thus allowing proper localisation of Stt4p to the actin cytoskeleton.","GO:0010506|regulation of autophagy;","GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0016021|integral component of membrane;",".","K21955","DRAM1; DNA damage-regulated autophagy modulator protein 1"]
["ENSRNOG00000059140",94,6.047061189,420,27.11598106,0.22300728,-2.164837285,{"v":1.41031e-50,"d":"1.41E-50"},{"v":4.5896e-50,"d":"4.59E-50"},"down","yes","Myo1g","protein_coding","chr14:81386701-81401843:-","gi|564384294|ref|XP_006251280.1|",5241,0,"PREDICTED: unconventional myosin-Ig isoform X1 [Rattus norvegicus]","gi|672076641|ref|XM_006251218.2|",3301,0,"PREDICTED: Rattus norvegicus myosin IG (Myo1g), transcript variant X1, mRNA","Q5SUA5",1971,0,"Unconventional myosin-Ig","YKL129c",498,{"v":2e-154,"d":"2.00E-154"},"COG5022","pfam00063","Myosin_head","Myosin head (motor domain).","GO:0002456|T cell mediated immunity;GO:0006887|exocytosis;GO:0006909|phagocytosis;GO:0031589|cell-substrate adhesion;GO:0038096|Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0071976|cell gliding;GO:0120117|T cell meandering migration;","GO:0001891|phagocytic cup;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0005902|microvillus;GO:0016459|myosin complex;GO:0030027|lamellipodium;GO:0030175|filopodium;GO:0031256|leading edge membrane;","GO:0005516|calmodulin binding;GO:0005524|ATP binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;GO:0043325|phosphatidylinositol-3,4-bisphosphate binding;","K10356","MYO1; myosin I"]
["ENSRNOG00000021079",452,29.07735806,1015,65.53028755,0.44372395,-1.172265669,{"v":1.47423e-50,"d":"1.47E-50"},{"v":4.79485e-50,"d":"4.79E-50"},"down","yes","Fxyd1","protein_coding","chr1:86287165-86291278:-","gi|148692015|gb|EDL23962.1|",417,{"v":3e-48,"d":"3.00E-48"},"FXYD domain-containing ion transport regulator 1, isoform CRA_e, partial [Mus musculus]","gi|672035853|ref|XM_008759184.1|",542,0,"PREDICTED: Rattus norvegicus FXYD domain-containing ion transport regulator 1 (Fxyd1), transcript variant X3, mRNA","O08589",126,{"v":5e-35,"d":"5.00E-35"},"Phospholemman",".",".",".",".","pfam02038","ATP1G1_PLM_MAT8","ATP1G1/PLM/MAT8 family.","GO:0006811|ion transport;GO:0006813|potassium ion transport;GO:0006814|sodium ion transport;GO:0007420|brain development;GO:0010734|negative regulation of protein glutathionylation;GO:0032892|positive regulation of organic acid transport;GO:0051480|regulation of cytosolic calcium ion concentration;GO:0086004|regulation of cardiac muscle cell contraction;GO:0086036|regulation of cardiac muscle cell membrane potential;GO:1903278|positive regulation of sodium ion export across plasma membrane;GO:1903406|regulation of sodium:potassium-exchanging ATPase activity;GO:1903797|positive regulation of inorganic anion transmembrane transport;GO:2000649|regulation of sodium ion transmembrane transporter activity;","GO:0005886|plasma membrane;GO:0005890|sodium:potassium-exchanging ATPase complex;GO:0005901|caveola;GO:0014704|intercalated disc;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0030315|T-tubule;GO:0042383|sarcolemma;","GO:0005515|protein binding;GO:0017022|myosin binding;GO:0017080|sodium channel regulator activity;GO:0051117|ATPase binding;","K13360","FXYD1, PLM; FXYD domain-containing ion transport regulator 1"]
["ENSRNOG00000033579",55,3.5381741,336,21.69278484,0.163103729,-2.616138329,{"v":1.55129E-50,"d":"1.55E-50"},{"v":5.04263e-50,"d":"5.04E-50"},"down","yes","Glt8d2","protein_coding","chr7:21029525-21081080:+","gi|564308154|ref|XP_006226042.1|",1412,0,"PREDICTED: glycosyltransferase 8 domain-containing protein 2 isoform X3 [Rattus norvegicus]","gi|672021490|ref|XM_006225980.2|",1715,0,"PREDICTED: Rattus norvegicus glycosyltransferase 8 domain containing 2 (Glt8d2), transcript variant X3, mRNA","Q2HJ96",482,{"v":4e-163,"d":"4.00E-163"},"Glycosyltransferase 8 domain-containing protein 2",".",".",".",".","pfam01501","Glyco_transf_8","Glycosyl transferase family 8. This family includes enzymes that transfer sugar residues to donor molecules. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. This family includes Lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, and glycogenin glucosyltransferase.",".","GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;","GO:0016757|transferase activity, transferring glycosyl groups;",".","."]
["ENSRNOG00000011750",91,5.854069875,413,26.66404804,0.21954918,-2.187383951,{"v":2.18374e-50,"d":"2.18E-50"},{"v":7.08234e-50,"d":"7.08E-50"},"down","yes","Fam180a","protein_coding","chr4:63992867-64008047:-","gi|157820567|ref|NP_001102091.1|",710,{"v":1E-87,"d":"1.00E-87"},"protein FAM180A precursor [Rattus norvegicus]","gi|157820566|ref|NM_001108621.1|",1573,0,"Rattus norvegicus family with sequence similarity 180, member A (Fam180a), mRNA","Q8BR21",254,{"v":6e-80,"d":"6.00E-80"},"Protein FAM180A",".",".",".",".","pfam15173","FAM180","FAM180 family. This family of proteins is found in eukaryotes. Proteins in this family are typically between 117 and 182 amino acids in length. There are two conserved sequence motifs: ELAS and DFE. The function of this family is unknown.",".",".",".",".","."]
["ENSRNOG00000051915",397,25.53918396,931,60.10709134,0.42489469,-1.23482278,{"v":2.33189e-50,"d":"2.33E-50"},{"v":7.55855e-50,"d":"7.56E-50"},"down","yes","Spred3","protein_coding","chr1:84459314-84470249:-","gi|672035712|ref|XP_008757366.1|",1134,{"v":3e-140,"d":"3.00E-140"},"PREDICTED: sprouty-related, EVH1 domain-containing protein 3 isoform X1 [Rattus norvegicus]","gi|672035715|ref|XM_008759146.1|",3500,0,"PREDICTED: Rattus norvegicus sprouty-related, EVH1 domain containing 3 (Spred3), transcript variant X3, mRNA","Q6P6N5",422,{"v":2e-134,"d":"2.00E-134"},"Sprouty-related, EVH1 domain-containing protein 3",".",".",".",".","pfam05210","Sprouty","Sprouty protein (Spry). This family consists of eukaryotic Sprouty protein homologues. Sprouty proteins have been revealed as inhibitors of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases. The sprouty gene has found to be expressed in the the brain, cochlea, nasal organs, teeth, salivary gland, lungs, digestive tract, kidneys and limb buds in mice.","GO:0010719|negative regulation of epithelial to mesenchymal transition;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0043409|negative regulation of MAPK cascade;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:1902747|negative regulation of lens fiber cell differentiation;","GO:0005886|plasma membrane;","GO:0019901|protein kinase binding;","K04703","SPRED; sprouty-related, EVH1 domain-containing protein"]
["ENSRNOG00000016119",121,7.78398302,471,30.4086359,0.255979356,-1.965900632,{"v":3.96231e-50,"d":"3.96E-50"},{"v":1.28215E-49,"d":"1.28E-49"},"down","yes","Fzd7","protein_coding","chr9:60930875-60935781:+","gi|29437351|gb|AAH49781.1|",3052,0,"Fzd7 protein, partial [Mus musculus]","gi|56236255|gb|AC132574.3|",3610,0,"Mus musculus BAC clone RP24-421H8 from 1, complete sequence","Q61090",1113,0,"Frizzled-7",".",".",".",".","pfam01534","Frizzled","Frizzled/Smoothened family membrane region. This family contains the membrane spanning region of frizzled and smoothened receptors. This membrane region is predicted to contain seven transmembrane alpha helices. Proteins related to Drosophila frizzled are receptors for Wnt (mediating the beta-catenin signalling pathway), but also the planar cell polarity (PCP) pathway and the Wnt/calcium pathway. The predominantly alpha-helical Cys-rich ligand-binding region (CRD) of Frizzled is both necessary and sufficient for Wnt binding. The smoothened receptor mediates hedgehog signalling.","GO:0006355|regulation of transcription, DNA-templated;GO:0010812|negative regulation of cell-substrate adhesion;GO:0014834|skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration;GO:0019827|stem cell population maintenance;GO:0033077|T cell differentiation in thymus;GO:0034446|substrate adhesion-dependent cell spreading;GO:0035567|non-canonical Wnt signaling pathway;GO:0038031|non-canonical Wnt signaling pathway via JNK cascade;GO:0042327|positive regulation of phosphorylation;GO:0042666|negative regulation of ectodermal cell fate specification;GO:0045893|positive regulation of transcription, DNA-templated;GO:0048103|somatic stem cell division;GO:0060054|positive regulation of epithelial cell proliferation involved in wound healing;GO:0060070|canonical Wnt signaling pathway;GO:0060231|mesenchymal to epithelial transition;GO:0060828|regulation of canonical Wnt signaling pathway;GO:2000726|negative regulation of cardiac muscle cell differentiation;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0055038|recycling endosome membrane;","GO:0005109|frizzled binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0017147|Wnt-protein binding;GO:0030165|PDZ domain binding;GO:0042813|Wnt-activated receptor activity;","K02432","FZD1_7, fz; frizzled 1/7"]
["ENSRNOG00000016044",15,0.964956573,231,14.91378958,0.064702306,-3.950039065,{"v":6.5692e-50,"d":"6.57E-50"},{"v":2.11851e-49,"d":"2.12E-49"},"down","yes","Mab21l3","protein_coding","chr2:189248895-189271652:-","gi|157824039|ref|NP_001099926.1|",2285,0,"protein mab-21-like 3 [Rattus norvegicus]","gi|157824038|ref|NM_001106456.1|",3926,0,"Rattus norvegicus mab-21-like 3 (C. elegans) (Mab21l3), mRNA",".",".",".",".",".",".",".",".","pfam03281","Mab-21","Mab-21 protein. This family contains Mab-21 and Mab-21 like proteins. In C. elegans these proteins are required for several aspects of embryonic development.",".",".",".",".","."]
["ENSRNOG00000001752",331,21.29337504,826,53.32809608,0.399289992,-1.324491184,{"v":7.53758e-50,"d":"7.54E-50"},{"v":2.42669E-49,"d":"2.43E-49"},"down","yes","Nrros","protein_coding","chr11:68628712-68646142:+","gi|68163431|ref|NP_001020166.1|",3464,0,"negative regulator of reactive oxygen species precursor [Rattus norvegicus]","gi|68163430|ref|NM_001024995.1|",2472,0,"Rattus norvegicus negative regulator of reactive oxygen species (Nrros), mRNA","Q5BK65",1339,0,"Negative regulator of reactive oxygen species","MA2301_1",72.4,{"v":4e-13,"d":"4.00E-13"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0006801|superoxide metabolic process;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0014005|microglia development;GO:0035583|sequestering of TGFbeta in extracellular matrix;GO:0036364|transforming growth factor beta1 activation;","GO:0005576|extracellular region;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0050431|transforming growth factor beta binding;",".","."]
["ENSRNOG00000017260",159,10.22853967,539,34.79884235,0.293933332,-1.766439127,{"v":1.1969E-49,"d":"1.20E-49"},{"v":3.8447e-49,"d":"3.84E-49"},"down","yes","Cdr2","protein_coding","chr1:175502838-175537472:-","gi|71043860|ref|NP_001020853.1|",2117,0,"cerebellar degeneration-related protein 2 [Rattus norvegicus]","gi|71043859|ref|NM_001025682.1|",2194,0,"Rattus norvegicus cerebellar degeneration-related protein 2 (Cdr2), mRNA","P97817",793,0,"Cerebellar degeneration-related protein 2",".",".",".",".","pfam04849","HAP1_N","HAP1 N-terminal conserved region. This family represents an N-terminal conserved region found in several huntingtin-associated protein 1 (HAP1) homologues. HAP1 binds to huntingtin in a polyglutamine repeat-length-dependent manner. However, its possible role in the pathogenesis of Huntington's disease is unclear. This family also includes a similar N-terminal conserved region from hypothetical protein products of ALS2CR3 genes found in the human juvenile amyotrophic lateral sclerosis critical region 2q33-2q34.",".","GO:0005737|cytoplasm;",".",".","."]
["ENSRNOG00000031515",21,1.350939202,247,15.94677933,0.084715489,-3.561230428,{"v":1.20856e-49,"d":"1.21E-49"},{"v":3.87997e-49,"d":"3.88E-49"},"down","yes","Klra2","protein_coding","chr4:164909969-164985338:-","gi|57222300|ref|NP_001009486.1|",1309,{"v":2E-167,"d":"2.00E-167"},"killer cell lectin-like receptor 2 [Rattus norvegicus]","gi|55250451|gb|BC085917.1|",3540,0,"Rattus norvegicus killer cell lectin-like receptor, subfamily A, member 2, mRNA (cDNA clone MGC:94821 IMAGE:7108565), complete cds","Q60660",283,{"v":4e-85,"d":"4.00E-85"},"Killer cell lectin-like receptor 2",".",".",".",".","pfam08391","Ly49","Ly49-like protein, N-terminal region. The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).","GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;",".","."]
["ENSRNOG00000070531",10,0.643304382,215,13.88079983,0.046344907,-4.431445374,{"v":1.701e-49,"d":"1.70E-49"},{"v":5.44253e-49,"d":"5.44E-49"},"down","yes","Ltb","protein_coding","chr20:3627537-3629381:-","gi|47059114|ref|NP_997672.1|",1302,{"v":6e-177,"d":"6.00E-177"},"lymphotoxin-beta [Rattus norvegicus]","gi|672085855|ref|XM_008772776.1|",1167,0,"PREDICTED: Rattus norvegicus lymphotoxin-beta (LOC103694381), mRNA","P41155",449,{"v":5e-156,"d":"5.00E-156"},"Lymphotoxin-beta",".",".",".",".","pfam00229","TNF","TNF(tumor Necrosis Factor) family.",".",".",".",".","."]
["ENSRNOG00000020325",238,15.31064429,674,43.51469341,0.351849986,-1.506967637,{"v":1.9175e-49,"d":"1.92E-49"},{"v":6.12495e-49,"d":"6.12E-49"},"down","yes","Calhm2","protein_coding","chr1:246022324-246028218:-","gi|148710082|gb|EDL42028.1|",1770,0,"RIKEN cDNA 2810048G17, isoform CRA_a, partial [Mus musculus]","gi|56605693|ref|NM_001008306.1|",1833,0,"Rattus norvegicus calcium homeostasis modulator 2 (Calhm2), mRNA","Q5RJQ8",667,0,"Calcium homeostasis modulator protein 2",".",".",".",".","pfam14798","Ca_hom_mod","Calcium homeostasis modulator. This family of proteins control cytosolic calcium concentration. They are transmembrane proteins which may be pore-forming ion channels.","GO:0043065|positive regulation of apoptotic process;GO:0098655|cation transmembrane transport;","GO:0005887|integral component of plasma membrane;","GO:0005261|cation channel activity;","K19739","CALHM2; calcium homeostasis modulator protein 2"]
["ENSRNOG00000015859",49,3.152191471,317,20.46610951,0.154020063,-2.698809805,{"v":2.38352e-49,"d":"2.38E-49"},{"v":7.59654e-49,"d":"7.60E-49"},"down","yes","Chdh","protein_coding","chr16:5194269-5225537:+","gi|38454200|ref|NP_942026.1|",3182,0,"choline dehydrogenase, mitochondrial [Rattus norvegicus]","gi|55741626|ref|NM_198731.2|",3402,0,"Rattus norvegicus choline dehydrogenase (Chdh), mRNA","Q6UPE0",1230,0,"Choline dehydrogenase, mitochondrial","mll7609",547,0,"COG2303","pfam00732","GMC_oxred_N","GMC oxidoreductase. This family of proteins bind FAD as a cofactor.","GO:0019285|glycine betaine biosynthetic process from choline;","GO:0005743|mitochondrial inner membrane;","GO:0008812|choline dehydrogenase activity;GO:0016491|oxidoreductase activity;GO:0050660|flavin adenine dinucleotide binding;","K00108","betA, CHDH; choline dehydrogenase [EC:1.1.99.1]"]
["ENSRNOG00000005214",67,4.310139358,357,23.0485839,0.18700235,-2.418871693,{"v":3.369E-49,"d":"3.37E-49"},{"v":1.07254E-48,"d":"1.07E-48"},"down","yes","Plek","protein_coding","chr14:91397019-91454131:-","gi|71043674|ref|NP_001020921.1|",1517,0,"pleckstrin [Rattus norvegicus]","gi|71043673|ref|NM_001025750.1|",1056,0,"Rattus norvegicus pleckstrin (Plek), mRNA","Q4KM33",588,0,"Pleckstrin",".",".",".",".","pfam00169","PH","PH domain. PH stands for pleckstrin homology.","GO:0002244|hematopoietic progenitor cell differentiation;GO:0002576|platelet degranulation;GO:0006904|vesicle docking involved in exocytosis;GO:0007229|integrin-mediated signaling pathway;GO:0010572|positive regulation of platelet activation;GO:0010920|negative regulation of inositol phosphate biosynthetic process;GO:0010925|positive regulation of inositol-polyphosphate 5-phosphatase activity;GO:0030030|cell projection organization;GO:0030836|positive regulation of actin filament depolymerization;GO:0030845|phospholipase C-inhibiting G protein-coupled receptor signaling pathway;GO:0030866|cortical actin cytoskeleton organization;GO:0031529|ruffle organization;GO:0031532|actin cytoskeleton reorganization;GO:0032233|positive regulation of actin filament bundle assembly;GO:0033625|positive regulation of integrin activation;GO:0035556|intracellular signal transduction;GO:0045744|negative regulation of G protein-coupled receptor signaling pathway;GO:0046488|phosphatidylinositol metabolic process;GO:0060305|regulation of cell diameter;GO:0070493|thrombin-activated receptor signaling pathway;GO:0070527|platelet aggregation;GO:0070528|protein kinase C signaling;GO:0070560|protein secretion by platelet;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0032587|ruffle membrane;","GO:0005080|protein kinase C binding;GO:0042803|protein homodimerization activity;GO:0043325|phosphatidylinositol-3,4-bisphosphate binding;","K19993","PLEK; pleckstrin"]
["ENSRNOG00000026053",87,5.596748122,399,25.760182,0.217263532,-2.20248206,{"v":3.84449e-49,"d":"3.84E-49"},{"v":1.22323e-48,"d":"1.22E-48"},"down","yes","Grem1","protein_coding","chr3:100512313-100524082:-","gi|585648865|ref|XP_006883110.1|",775,{"v":1E-91,"d":"1.00E-91"},"PREDICTED: gremlin-1 isoform X1 [Elephantulus edwardii]","gi|393794769|ref|NM_019282.3|",3656,0,"Rattus norvegicus gremlin 1 (Grem1), mRNA","O35793",302,{"v":5e-93,"d":"5.00E-93"},"Gremlin-1",".",".",".",".","pfam03045","DAN","DAN domain. This domain contains 9 conserved cysteines and is extracellular. Therefore the cysteines may form disulphide bridges. This family of proteins has been termed the DAN family after the first member to be reported. This family includes DAN, Cerberus and Gremlin. The gremlin protein is an antagonist of bone morphogenetic protein signaling. It is postulated that all members of this family antagonise different TGF beta pfam00019 ligands. Recent work shows that the DAN protein is not an efficient antagonist of BMP-2/4 class signals, we found that DAN was able to interact with GDF-5 in a frog embryo assay, suggesting that DAN may regulate signaling by the GDF-5/6/7 class of BMPs in vivo.","GO:0000902|cell morphogenesis;GO:0001525|angiogenesis;GO:0002042|cell migration involved in sprouting angiogenesis;GO:0002092|positive regulation of receptor internalization;GO:0002689|negative regulation of leukocyte chemotaxis;GO:0003257|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation;GO:0003337|mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0006915|apoptotic process;GO:0007165|signal transduction;GO:0007171|activation of transmembrane receptor protein tyrosine kinase activity;GO:0007267|cell-cell signaling;GO:0008284|positive regulation of cell proliferation;GO:0009887|animal organ morphogenesis;GO:0009954|proximal/distal pattern formation;GO:0010717|regulation of epithelial to mesenchymal transition;GO:0030199|collagen fibril organization;GO:0030308|negative regulation of cell growth;GO:0030326|embryonic limb morphogenesis;GO:0030502|negative regulation of bone mineralization;GO:0030514|negative regulation of BMP signaling pathway;GO:0032331|negative regulation of chondrocyte differentiation;GO:0033689|negative regulation of osteoblast proliferation;GO:0038098|sequestering of BMP from receptor via BMP binding;GO:0043066|negative regulation of apoptotic process;GO:0043542|endothelial cell migration;GO:0045668|negative regulation of osteoblast differentiation;GO:0045766|positive regulation of angiogenesis;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046851|negative regulation of bone remodeling;GO:0048263|determination of dorsal identity;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051893|regulation of focal adhesion assembly;GO:0051973|positive regulation of telomerase activity;GO:0060173|limb development;GO:0060394|negative regulation of pathway-restricted SMAD protein phosphorylation;GO:0060676|ureteric bud formation;GO:0061098|positive regulation of protein tyrosine kinase activity;GO:0090027|negative regulation of monocyte chemotaxis;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0090190|positive regulation of branching involved in ureteric bud morphogenesis;GO:0090291|negative regulation of osteoclast proliferation;GO:1900086|positive regulation of peptidyl-tyrosine autophosphorylation;GO:1900155|negative regulation of bone trabecula formation;GO:1900158|negative regulation of bone mineralization involved in bone maturation;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:2000273|positive regulation of signaling receptor activity;GO:2000727|positive regulation of cardiac muscle cell differentiation;","GO:0005615|extracellular space;GO:0009986|cell surface;","GO:0005125|cytokine activity;GO:0005515|protein binding;GO:0030297|transmembrane receptor protein tyrosine kinase activator activity;GO:0036122|BMP binding;GO:0042803|protein homodimerization activity;GO:0043184|vascular endothelial growth factor receptor 2 binding;GO:0048018|receptor ligand activity;","K23318","GREM; gremlin"]
["ENSRNOG00000012109",439,28.24106236,985,63.59343176,0.444087724,-1.171083404,{"v":4.85654E-49,"d":"4.86E-49"},{"v":1.54439e-48,"d":"1.54E-48"},"down","yes","Otulinl","protein_coding","chr2:78408593-78433838:-","gi|83320082|ref|NP_001032737.1|",1672,0,"inactive ubiquitin thioesterase FAM105A [Rattus norvegicus]","gi|83320081|ref|NM_001037648.1|",1376,0,"Rattus norvegicus family with sequence similarity 105, member A (Fam105a), mRNA",".",".",".",".",".",".",".",".","pfam10320","7TM_GPCR_Srsx","Serpentine type 7TM GPCR chemoreceptor Srsx. Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srsx is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.",".","GO:0005635|nuclear envelope;GO:0005737|cytoplasm;GO:0042406|extrinsic component of endoplasmic reticulum membrane;",".",".","."]
["ENSRNOG00000015357",18,1.157947887,236,15.23659888,0.075997793,-3.717898667,{"v":5.44307e-49,"d":"5.44E-49"},{"v":1.72994e-48,"d":"1.73E-48"},"down","yes","Bmper","protein_coding","chr8:21732225-21977256:+","gi|209447103|ref|NP_001129271.1|",3641,0,"BMP-binding endothelial regulator protein precursor [Rattus norvegicus]","gi|209447102|ref|NM_001135799.1|",3785,0,"Rattus norvegicus BMP-binding endothelial regulator (Bmper), mRNA","Q8CJ69",1389,0,"BMP-binding endothelial regulator protein",".",".",".",".","pfam00094","VWD","von Willebrand factor type D domain. Luciferin-2-monooxygenase from Vargula hilgendorfii contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.","GO:0001568|blood vessel development;GO:0001657|ureteric bud development;GO:0002043|blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:0010594|regulation of endothelial cell migration;GO:0030514|negative regulation of BMP signaling pathway;GO:0042118|endothelial cell activation;GO:0045765|regulation of angiogenesis;GO:0048839|inner ear development;GO:0060393|regulation of pathway-restricted SMAD protein phosphorylation;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:1903672|positive regulation of sprouting angiogenesis;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0031012|extracellular matrix;",".","K24517","BMPER; BMP-binding endothelial regulator protein"]
["ENSRNOG00000007178",41,2.637547966,296,19.11031046,0.138017013,-2.85708198,{"v":6.65344e-49,"d":"6.65E-49"},{"v":2.1111E-48,"d":"2.11E-48"},"down","yes","Cd8a","protein_coding","chr4:103365804-103370040:+","gi|13928726|ref|NP_113726.1|",1047,{"v":4e-138,"d":"4.00E-138"},"T-cell surface glycoprotein CD8 alpha chain precursor [Rattus norvegicus]","gi|672049903|ref|XM_006236630.2|",1388,0,"PREDICTED: Rattus norvegicus CD8a molecule (Cd8a), transcript variant X2, mRNA","P07725",407,{"v":1E-139,"d":"1.00E-139"},"T-cell surface glycoprotein CD8 alpha chain",".",".",".",".","pfam00047","ig","Immunoglobulin domain. Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions. The Pfam alignments do not include the first and last strand of the immunoglobulin-like domain.","GO:0002456|T cell mediated immunity;GO:0006954|inflammatory response;GO:0007166|cell surface receptor signaling pathway;GO:0042110|T cell activation;GO:0045065|cytotoxic T cell differentiation;GO:0050850|positive regulation of calcium-mediated signaling;GO:0051607|defense response to virus;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0044853|plasma membrane raft;","GO:0019901|protein kinase binding;GO:0023024|MHC class I protein complex binding;GO:0042802|identical protein binding;","K06458","CD8A; T-cell surface glycoprotein CD8 alpha chain"]
["ENSRNOG00000005388",454,29.20601894,1006,64.94923081,0.449674593,-1.153046722,{"v":7.2551e-49,"d":"7.26E-49"},{"v":2.30073e-48,"d":"2.30E-48"},"down","yes","Rassf3","protein_coding","chr7:56935973-57000553:-","gi|564359431|ref|XP_006241464.1|",1130,{"v":6e-143,"d":"6.00E-143"},"PREDICTED: ras association domain-containing protein 3 isoform X1 [Rattus norvegicus]","gi|672058801|ref|XM_006241402.2|",3317,0,"PREDICTED: Rattus norvegicus Ras association (RalGDS/AF-6) domain family member 3 (Rassf3), transcript variant X1, mRNA","Q99P51",409,{"v":5e-133,"d":"5.00E-133"},"Ras association domain-containing protein 3",".",".",".",".","pfam00788","RA","Ras association (RalGDS/AF-6) domain. RasGTP effectors (in cases of AF6, canoe and RalGDS); putative RasGTP effectors in other cases. Recent evidence (not yet in MEDLINE) shows that some RA domains do NOT bind RasGTP. Predicted structure similar to that determined, and that of the RasGTP-binding domain of Raf kinase.","GO:0007165|signal transduction;GO:0042981|regulation of apoptotic process;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0042802|identical protein binding;","K09852","RASSF3; Ras association domain-containing protein 3"]
["ENSRNOG00000001908",44,2.83053928,303,19.56224348,0.144694001,-2.788922984,{"v":7.65643e-49,"d":"7.66E-49"},{"v":2.42665e-48,"d":"2.43E-48"},"down","yes","Klhl6","protein_coding","chr11:80970917-81009677:+","gi|157786760|ref|NP_001099337.1|",3338,0,"kelch-like protein 6 [Rattus norvegicus]","gi|157786759|ref|NM_001105867.1|",2415,0,"Rattus norvegicus kelch-like family member 6 (Klhl6), mRNA","Q6V595",1277,0,"Kelch-like protein 6",".",".",".",".","pfam07707","BACK","BTB And C-terminal Kelch. This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).","GO:0002467|germinal center formation;GO:0009617|response to bacterium;GO:0050853|B cell receptor signaling pathway;",".",".","K10444","KLHL6; kelch-like protein 6"]
["ENSRNOG00000025448",459,29.52767113,1013,65.40116383,0.451485408,-1.147248735,{"v":8.20745E-49,"d":"8.21E-49"},{"v":2.59697E-48,"d":"2.60E-48"},"down","yes","Limd2","protein_coding","chr10:91090280-91092775:-","gi|71043772|ref|NP_001020886.1|",607,{"v":1e-72,"d":"1.00E-72"},"LIM domain-containing protein 2 [Rattus norvegicus]","gi|672069818|ref|XM_006247622.2|",987,0,"PREDICTED: Rattus norvegicus LIM domain containing 2 (Limd2), transcript variant X2, mRNA","Q4KM31",238,{"v":4e-74,"d":"4.00E-74"},"LIM domain-containing protein 2",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.",".","GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0046872|metal ion binding;",".","."]
["ENSRNOG00000017712",0,0.032165219,249,16.07590305,0.002000834,-8.965182551,{"v":8.93798e-49,"d":"8.94E-49"},{"v":2.82343e-48,"d":"2.82E-48"},"down","yes","Cartpt","protein_coding","chr2:31255098-31290713:-","gi|332233797|ref|XP_003266091.1|",466,{"v":1E-52,"d":"1.00E-52"},"PREDICTED: cocaine- and amphetamine-regulated transcript protein [Nomascus leucogenys]","gi|672041190|ref|XM_006231843.2|",827,0,"PREDICTED: Rattus norvegicus CART prepropeptide (Cartpt), transcript variant X1, mRNA","Q16568",183,{"v":7e-54,"d":"7.00E-54"},"Cocaine- and amphetamine-regulated transcript protein",".",".",".",".","pfam06373","CART","Cocaine and amphetamine regulated transcript protein (CART). This family consists of several cocaine and amphetamine regulated transcript type I protein (CART) sequences. Cocaine and amphetamine regulated transcript (CART) peptide has been shown to be an anorectic peptide that inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. The C-terminal part containing the three disulfide bridges is the biologically active part of the molecule affecting food intake. The solution structure of the active part of CART has a fold equivalent to other functionally distinct small proteins. CART consists mainly of turns and loops spanned by a compact framework composed by a few small stretches of antiparallel beta-sheet common to cystine knots.","GO:0001678|cellular glucose homeostasis;GO:0001696|gastric acid secretion;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007218|neuropeptide signaling pathway;GO:0007268|chemical synaptic transmission;GO:0008343|adult feeding behavior;GO:0009267|cellular response to starvation;GO:0032099|negative regulation of appetite;GO:0032812|positive regulation of epinephrine secretion;GO:0032922|circadian regulation of gene expression;GO:0043410|positive regulation of MAPK cascade;GO:0045777|positive regulation of blood pressure;GO:0045779|negative regulation of bone resorption;GO:0045860|positive regulation of protein kinase activity;GO:0046850|regulation of bone remodeling;GO:0050796|regulation of insulin secretion;GO:0051971|positive regulation of transmission of nerve impulse;GO:0070093|negative regulation of glucagon secretion;GO:0070253|somatostatin secretion;","GO:0005615|extracellular space;GO:0030141|secretory granule;GO:0045202|synapse;","GO:0005184|neuropeptide hormone activity;GO:0005515|protein binding;","K25453","CARTPT; cocaine- and amphetamine-regulated transcript protein"]
["ENSRNOG00000062578",220,14.1526964,640,41.31959018,0.342517831,-1.545749001,{"v":9.1943e-49,"d":"9.19E-49"},{"v":2.90279e-48,"d":"2.90E-48"},"down","yes","Rhou","protein_coding","chr19:51641227-51650552:+","gi|19923060|ref|NP_598716.1|",1074,{"v":9e-137,"d":"9.00E-137"},"rho-related GTP-binding protein RhoU [Mus musculus]","gi|672085483|ref|XM_008772678.1|",2259,0,"PREDICTED: Rattus norvegicus similar to ras homolog gene family, member U (LOC678766), transcript variant X2, mRNA","Q9EQT3",418,{"v":3e-138,"d":"3.00E-138"},"Rho-related GTP-binding protein RhoU",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.",".",".",".",".","."]
["ENSRNOG00000068243",18,1.157947887,234,15.10747516,0.076647347,-3.705620337,{"v":1.7633e-48,"d":"1.76E-48"},{"v":5.53948e-48,"d":"5.54E-48"},"down","yes","Cdk5r1","protein_coding","chr10:65483941-65488456:+","gi|6753384|ref|NP_034001.1|",1404,{"v":2e-178,"d":"2.00E-178"},"cyclin-dependent kinase 5 activator 1 [Mus musculus]","gi|30722338|emb|AL591146.21|",2602,0,"Mouse DNA sequence from clone RP23-252E4 on chromosome 11, complete sequence","P61810",545,{"v":6e-180,"d":"6.00E-180"},"Cyclin-dependent kinase 5 activator 1",".",".",".",".","pfam03261","CDK5_activator","Cyclin-dependent kinase 5 activator protein.",".",".",".",".","."]
["ENSRNOG00000009945",17,1.093617449,231,14.91378958,0.07332928,-3.76946682,{"v":1.93518E-48,"d":"1.94E-48"},{"v":6.06942e-48,"d":"6.07E-48"},"down","yes","Pls1","protein_coding","chr8:96317849-96385195:-","gi|564364992|ref|XP_006243636.1|",3120,0,"PREDICTED: plastin-1 isoform X1 [Rattus norvegicus]","gi|672062966|ref|XM_006243575.2|",2918,0,"PREDICTED: Rattus norvegicus plastin 1 (Pls1), transcript variant X4, mRNA","Q3V0K9",1186,0,"Plastin-1","SPBC1778.06c",405,{"v":1E-127,"d":"1.00E-127"},"COG5069","pfam00307","CH","Calponin homology (CH) domain. The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.","GO:0001951|intestinal D-glucose absorption;GO:0008150|biological_process;GO:0032532|regulation of microvillus length;GO:0040018|positive regulation of multicellular organism growth;GO:0051017|actin filament bundle assembly;GO:0051639|actin filament network formation;GO:0060088|auditory receptor cell stereocilium organization;GO:0060121|vestibular receptor cell stereocilium organization;GO:1902896|terminal web assembly;GO:1903078|positive regulation of protein localization to plasma membrane;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005884|actin filament;GO:0005903|brush border;GO:0032420|stereocilium;GO:0032432|actin filament bundle;GO:1990357|terminal web;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;GO:0051015|actin filament binding;","K17275","PLS1; plastin-1"]
["ENSRNOG00000063127",21,1.350939202,242,15.62397004,0.086465809,-3.531726434,{"v":2.24386e-48,"d":"2.24E-48"},{"v":7.0337e-48,"d":"7.03E-48"},"down","yes","Ccr2","protein_coding","chr8:123734430-123742100:+","gi|11177914|ref|NP_068638.1|",1741,0,"C-C chemokine receptor type 2 [Rattus norvegicus]","gi|755532612|ref|XM_011243063.1|",2290,0,"PREDICTED: Mus musculus chemokine (C-C motif) receptor 2 (Ccr2), transcript variant X2, mRNA","O55193",675,0,"C-C chemokine receptor type 2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.",".",".",".",".","."]
["ENSRNOG00000020573",262,16.8545748,707,45.64523478,0.369251574,-1.437324023,{"v":2.25034e-48,"d":"2.25E-48"},{"v":7.05014e-48,"d":"7.05E-48"},"down","yes","Efna1","protein_coding","chr2:174681682-174690866:-","gi|672043177|ref|XP_008759449.1|",1406,0,"PREDICTED: ephrin-A1 isoform X1 [Rattus norvegicus]","gi|672043176|ref|XM_008761227.1|",1864,0,"PREDICTED: Rattus norvegicus ephrin A1 (Efna1), transcript variant X1, mRNA","P97553",395,{"v":4e-133,"d":"4.00E-133"},"Ephrin-A1",".",".",".",".","pfam00812","Ephrin","Ephrin.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001525|angiogenesis;GO:0001934|positive regulation of protein phosphorylation;GO:0003180|aortic valve morphogenesis;GO:0003183|mitral valve morphogenesis;GO:0003199|endocardial cushion to mesenchymal transition involved in heart valve formation;GO:0007411|axon guidance;GO:0010719|negative regulation of epithelial to mesenchymal transition;GO:0014028|notochord formation;GO:0016477|cell migration;GO:0030182|neuron differentiation;GO:0033628|regulation of cell adhesion mediated by integrin;GO:0034446|substrate adhesion-dependent cell spreading;GO:0043409|negative regulation of MAPK cascade;GO:0043410|positive regulation of MAPK cascade;GO:0043535|regulation of blood vessel endothelial cell migration;GO:0045765|regulation of angiogenesis;GO:0048013|ephrin receptor signaling pathway;GO:0050730|regulation of peptidyl-tyrosine phosphorylation;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050770|regulation of axonogenesis;GO:0050821|protein stabilization;GO:0061002|negative regulation of dendritic spine morphogenesis;GO:0061098|positive regulation of protein tyrosine kinase activity;GO:0070244|negative regulation of thymocyte apoptotic process;GO:1902004|positive regulation of amyloid-beta formation;GO:1902961|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process;GO:1903051|negative regulation of proteolysis involved in cellular protein catabolic process;","GO:0005576|extracellular region;GO:0005886|plasma membrane;GO:0046658|anchored component of plasma membrane;","GO:0046875|ephrin receptor binding;","K05462","EFNA; ephrin-A"]
["ENSRNOG00000009347",130,8.362956964,479,30.92513077,0.270425921,-1.886694652,{"v":2.50374e-48,"d":"2.50E-48"},{"v":7.83972e-48,"d":"7.84E-48"},"down","yes","Arhgap25","protein_coding","chr4:119896844-119974982:-","gi|157823601|ref|NP_001102717.1|",3289,0,"rho GTPase-activating protein 25 [Rattus norvegicus]","gi|157823600|ref|NM_001109247.1|",2982,0,"Rattus norvegicus Rho GTPase activating protein 25 (Arhgap25), mRNA","Q8BYW1",1216,0,"Rho GTPase-activating protein 25",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0006911|phagocytosis, engulfment;GO:0007015|actin filament organization;GO:0007165|signal transduction;GO:0051058|negative regulation of small GTPase mediated signal transduction;GO:0090630|activation of GTPase activity;","GO:0001891|phagocytic cup;","GO:0005096|GTPase activator activity;","K20642","ARHGAP22_24_25; Rho GTPase-activating protein 22/24/25"]
["ENSRNOG00000028856",541,34.80276706,1128,72.82577769,0.477890771,-1.065247188,{"v":3.1057e-48,"d":"3.11E-48"},{"v":9.70861e-48,"d":"9.71E-48"},"down","yes","Pknox2","protein_coding","chr8:36600636-36790940:-","gi|404312683|ref|NP_001258207.1|",1999,0,"homeobox protein PKNOX2 isoform 1 [Rattus norvegicus]","gi|298894204|emb|FQ221048.1|",3696,0,"Rattus norvegicus TL0ADA40YE19 mRNA sequence","Q8BG99",770,0,"Homeobox protein PKNOX2",".",".",".",".","pfam05920","Homeobox_KN","Homeobox KN domain. This is a homeobox transcription factor KN domain conserved from fungi to human and plants.","GO:0006357|regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0015629|actin cytoskeleton;GO:0015630|microtubule cytoskeleton;GO:0045171|intercellular bridge;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003785|actin monomer binding;GO:0043565|sequence-specific DNA binding;GO:0051015|actin filament binding;GO:1990837|sequence-specific double-stranded DNA binding;","K24891","PKNOX; homeobox protein PKNOX"]
["ENSRNOG00000006167",41,2.637547966,293,18.91662488,0.139430156,-2.842385469,{"v":3.4962e-48,"d":"3.50E-48"},{"v":1.09009e-47,"d":"1.09E-47"},"down","yes","Rasal3","protein_coding","chr7:11396090-11411465:-","gi|564358455|ref|XP_006241121.1|",4827,0,"PREDICTED: RAS protein activator like-3 isoform X1 [Rattus norvegicus]","gi|197381463|ref|NM_001134562.1|",3922,0,"Rattus norvegicus RAS protein activator like 3 (Rasal3), mRNA","Q8C2K5",1673,0,"RAS protein activator like-3",".",".",".",".","pfam00616","RasGAP","GTPase-activator protein for Ras-like GTPase. All alpha-helical domain that accelerates the GTPase activity of Ras, thereby \"switching\" it into an \"off\" position.","GO:0007165|signal transduction;GO:0043087|regulation of GTPase activity;GO:0046580|negative regulation of Ras protein signal transduction;GO:0051142|positive regulation of NK T cell proliferation;","GO:0005737|cytoplasm;GO:0098562|cytoplasmic side of membrane;","GO:0042802|identical protein binding;","K17634","RASAL3; RAS protein activator-like 3"]
["ENSRNOG00000019050",41,2.637547966,293,18.91662488,0.139430156,-2.842385469,{"v":3.4962e-48,"d":"3.50E-48"},{"v":1.09009e-47,"d":"1.09E-47"},"down","yes","ENSRNOG00000019050","protein_coding","chr1:232127170-232154435:+","gi|9910234|ref|NP_064481.1|",2382,0,"interferon-induced protein with tetratricopeptide repeats 1-like protein [Rattus norvegicus]","gi|9910233|ref|NM_020096.1|",1926,0,"Rattus norvegicus interferon-induced protein with tetratricopeptide repeats 1 (Ifit1), mRNA","Q64282",790,0,"Interferon-induced protein with tetratricopeptide repeats 1",".",".",".",".","pfam13414","TPR_11","TPR repeat.","GO:0009615|response to virus;GO:0009617|response to bacterium;GO:0035457|cellular response to interferon-alpha;GO:0035458|cellular response to interferon-beta;GO:0051607|defense response to virus;","GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0003723|RNA binding;","K14217","IFIT1; interferon-induced protein with tetratricopeptide repeats 1"]
["ENSRNOG00000053288",55,3.5381741,325,20.98260439,0.168624163,-2.568116814,{"v":5.49077e-48,"d":"5.49E-48"},{"v":1.70896e-47,"d":"1.71E-47"},"down","yes","Ank3","protein_coding","chr20:18602786-19086300:-","gi|585399439|emb|CDM21877.1|",19958,0,"480-kDa ankyrinG [Mus musculus]","gi|585399438|emb|HG915716.1|",8344,0,"Mus musculus Ank3 gene for 480-kDa ankyrinG, strain C57Bl6","Q12955",7061,0,"Ankyrin-3","all2748",198,{"v":1E-52,"d":"1.00E-52"},"COG0666","pfam00791","ZU5","ZU5 domain. Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.","GO:0000281|mitotic cytokinesis;GO:0007009|plasma membrane organization;GO:0007010|cytoskeleton organization;GO:0007165|signal transduction;GO:0007409|axonogenesis;GO:0007411|axon guidance;GO:0007528|neuromuscular junction development;GO:0010628|positive regulation of gene expression;GO:0010650|positive regulation of cell communication by electrical coupling;GO:0010765|positive regulation of sodium ion transport;GO:0010960|magnesium ion homeostasis;GO:0019228|neuronal action potential;GO:0034112|positive regulation of homotypic cell-cell adhesion;GO:0043001|Golgi to plasma membrane protein transport;GO:0043266|regulation of potassium ion transport;GO:0045162|clustering of voltage-gated sodium channels;GO:0045184|establishment of protein localization;GO:0045838|positive regulation of membrane potential;GO:0050808|synapse organization;GO:0071286|cellular response to magnesium ion;GO:0071709|membrane assembly;GO:0072659|protein localization to plasma membrane;GO:0072660|maintenance of protein location in plasma membrane;GO:0090314|positive regulation of protein targeting to membrane;GO:0099612|protein localization to axon;GO:1900827|positive regulation of membrane depolarization during cardiac muscle cell action potential;GO:1902260|negative regulation of delayed rectifier potassium channel activity;GO:2000651|positive regulation of sodium ion transmembrane transporter activity;GO:2001259|positive regulation of cation channel activity;","GO:0005764|lysosome;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0005923|bicellular tight junction;GO:0009925|basal plasma membrane;GO:0009986|cell surface;GO:0014704|intercalated disc;GO:0014731|spectrin-associated cytoskeleton;GO:0016020|membrane;GO:0016323|basolateral plasma membrane;GO:0016328|lateral plasma membrane;GO:0016529|sarcoplasmic reticulum;GO:0030018|Z disc;GO:0030315|T-tubule;GO:0030424|axon;GO:0030425|dendrite;GO:0031594|neuromuscular junction;GO:0033268|node of Ranvier;GO:0033270|paranode region of axon;GO:0042383|sarcolemma;GO:0043005|neuron projection;GO:0043034|costamere;GO:0043194|axon initial segment;GO:0045202|synapse;GO:0045211|postsynaptic membrane;","GO:0005200|structural constituent of cytoskeleton;GO:0005515|protein binding;GO:0008092|cytoskeletal protein binding;GO:0030507|spectrin binding;GO:0030674|protein binding, bridging;GO:0044325|ion channel binding;GO:0045296|cadherin binding;GO:0140031|phosphorylation-dependent protein binding;","K10380","ANK; ankyrin"]
["ENSRNOG00000003954",521,33.51615829,1097,70.82436004,0.473229243,-1.079388867,{"v":6.14113E-48,"d":"6.14E-48"},{"v":1.9093e-47,"d":"1.91E-47"},"down","yes","Il2rg","protein_coding","chrX:66392542-66399823:-","gi|149042199|gb|EDL95906.1|",1297,{"v":1E-169,"d":"1.00E-169"},"interleukin 2 receptor, gamma (severe combined immunodeficiency), isoform CRA_b [Rattus norvegicus]","gi|298914770|emb|FQ232752.1|",1289,0,"Rattus norvegicus TL0AEA64YI23 mRNA sequence","P34902",425,{"v":2E-150,"d":"2.00E-150"},"Cytokine receptor common subunit gamma",".",".",".",".","pfam09240","IL6Ra-bind","Interleukin-6 receptor alpha chain, binding. Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.","GO:0010468|regulation of gene expression;GO:0010628|positive regulation of gene expression;GO:0019221|cytokine-mediated signaling pathway;GO:0032831|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0033089|positive regulation of T cell differentiation in thymus;GO:0035723|interleukin-15-mediated signaling pathway;GO:0045579|positive regulation of B cell differentiation;GO:0045621|positive regulation of lymphocyte differentiation;GO:0050766|positive regulation of phagocytosis;","GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0043235|receptor complex;","GO:0004896|cytokine receptor activity;GO:0019955|cytokine binding;GO:0019976|interleukin-2 binding;GO:0042010|interleukin-15 receptor activity;","K05070","IL2RG, CD132; interleukin 2 receptor gamma"]
["ENSRNOG00000017539",26,1.672591393,253,16.33415049,0.102398432,-3.287734476,{"v":1.0147E-47,"d":"1.01E-47"},{"v":3.14617e-47,"d":"3.15E-47"},"down","yes","Mmp9","protein_coding","chr3:153683858-153692120:+","gi|149042905|gb|EDL96479.1|",3390,0,"matrix metallopeptidase 9 [Rattus norvegicus]","gi|13591992|ref|NM_031055.1|",2975,0,"Rattus norvegicus matrix metallopeptidase 9 (Mmp9), mRNA","P50282",1275,0,"Matrix metalloproteinase-9",".",".",".",".","pfam00413","Peptidase_M10","Matrixin. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.","GO:0001501|skeletal system development;GO:0001503|ossification;GO:0001666|response to hypoxia;GO:0001822|kidney development;GO:0001934|positive regulation of protein phosphorylation;GO:0002687|positive regulation of leukocyte migration;GO:0006508|proteolysis;GO:0006979|response to oxidative stress;GO:0007507|heart development;GO:0007566|embryo implantation;GO:0007567|parturition;GO:0007568|aging;GO:0007584|response to nutrient;GO:0009314|response to radiation;GO:0009408|response to heat;GO:0009410|response to xenobiotic stimulus;GO:0009612|response to mechanical stimulus;GO:0009644|response to high light intensity;GO:0010033|response to organic substance;GO:0014070|response to organic cyclic compound;GO:0019087|transformation of host cell by virus;GO:0030198|extracellular matrix organization;GO:0030335|positive regulation of cell migration;GO:0030574|collagen catabolic process;GO:0031915|positive regulation of synaptic plasticity;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0032526|response to retinoic acid;GO:0033189|response to vitamin A;GO:0034612|response to tumor necrosis factor;GO:0034614|cellular response to reactive oxygen species;GO:0035094|response to nicotine;GO:0035987|endodermal cell differentiation;GO:0043065|positive regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0043388|positive regulation of DNA binding;GO:0045471|response to ethanol;GO:0045742|positive regulation of epidermal growth factor receptor signaling pathway;GO:0045766|positive regulation of angiogenesis;GO:0048147|negative regulation of fibroblast proliferation;GO:0048771|tissue remodeling;GO:0050900|leukocyte migration;GO:0051549|positive regulation of keratinocyte migration;GO:0055093|response to hyperoxia;GO:0071222|cellular response to lipopolysaccharide;GO:0071276|cellular response to cadmium ion;GO:0071283|cellular response to iron(III) ion;GO:0071345|cellular response to cytokine stimulus;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071404|cellular response to low-density lipoprotein particle stimulus;GO:0071460|cellular response to cell-matrix adhesion;GO:0071492|cellular response to UV-A;GO:0090200|positive regulation of release of cytochrome c from mitochondria;GO:1900122|positive regulation of receptor binding;GO:1904645|response to amyloid-beta;GO:1904707|positive regulation of vascular smooth muscle cell proliferation;GO:2000697|negative regulation of epithelial cell differentiation involved in kidney development;GO:2001243|negative regulation of intrinsic apoptotic signaling pathway;GO:2001258|negative regulation of cation channel activity;GO:2001268|negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0031012|extracellular matrix;GO:0032991|protein-containing complex;","GO:0001968|fibronectin binding;GO:0004175|endopeptidase activity;GO:0004222|metalloendopeptidase activity;GO:0004252|serine-type endopeptidase activity;GO:0005515|protein binding;GO:0008233|peptidase activity;GO:0008237|metallopeptidase activity;GO:0008270|zinc ion binding;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;","K01403","MMP9; matrix metalloproteinase-9 (gelatinase B) [EC:3.4.24.35]"]
["ENSRNOG00000001296",45,2.894869718,300,19.3685579,0.149462326,-2.742146214,{"v":1.45829E-47,"d":"1.46E-47"},{"v":4.51178e-47,"d":"4.51E-47"},"down","yes","P2rx7","protein_coding","chr12:33879745-33934619:-","gi|672072946|ref|XP_008767445.1|",3013,0,"PREDICTED: P2X purinoceptor 7 isoform X1 [Rattus norvegicus]","gi|672072945|ref|XM_008769223.1|",3429,0,"PREDICTED: Rattus norvegicus purinergic receptor P2X, ligand-gated ion channel, 7 (P2rx7), transcript variant X1, mRNA","Q64663",1103,0,"P2X purinoceptor 7",".",".",".",".","pfam00864","P2X_receptor","ATP P2X receptor.","GO:0000902|cell morphogenesis;GO:0001819|positive regulation of cytokine production;GO:0001845|phagolysosome assembly;GO:0001916|positive regulation of T cell mediated cytotoxicity;GO:0001934|positive regulation of protein phosphorylation;GO:0002028|regulation of sodium ion transport;GO:0006468|protein phosphorylation;GO:0006509|membrane protein ectodomain proteolysis;GO:0006649|phospholipid transfer to membrane;GO:0006812|cation transport;GO:0006816|calcium ion transport;GO:0006884|cell volume homeostasis;GO:0006900|vesicle budding from membrane;GO:0006954|inflammatory response;GO:0007005|mitochondrion organization;GO:0007009|plasma membrane organization;GO:0007166|cell surface receptor signaling pathway;GO:0008219|cell death;GO:0009410|response to xenobiotic stimulus;GO:0009612|response to mechanical stimulus;GO:0009617|response to bacterium;GO:0010033|response to organic substance;GO:0010043|response to zinc ion;GO:0010467|gene expression;GO:0010524|positive regulation of calcium ion transport into cytosol;GO:0010628|positive regulation of gene expression;GO:0012501|programmed cell death;GO:0014049|positive regulation of glutamate secretion;GO:0014054|positive regulation of gamma-aminobutyric acid secretion;GO:0014070|response to organic cyclic compound;GO:0015695|organic cation transport;GO:0016079|synaptic vesicle exocytosis;GO:0016485|protein processing;GO:0017121|phospholipid scrambling;GO:0019228|neuronal action potential;GO:0019233|sensory perception of pain;GO:0030163|protein catabolic process;GO:0030501|positive regulation of bone mineralization;GO:0031668|cellular response to extracellular stimulus;GO:0032060|bleb assembly;GO:0032308|positive regulation of prostaglandin secretion;GO:0032496|response to lipopolysaccharide;GO:0032730|positive regulation of interleukin-1 alpha production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032755|positive regulation of interleukin-6 production;GO:0032963|collagen metabolic process;GO:0033198|response to ATP;GO:0034405|response to fluid shear stress;GO:0034767|positive regulation of ion transmembrane transport;GO:0035590|purinergic nucleotide receptor signaling pathway;GO:0042098|T cell proliferation;GO:0043029|T cell homeostasis;GO:0043065|positive regulation of apoptotic process;GO:0043085|positive regulation of catalytic activity;GO:0043132|NAD transport;GO:0043406|positive regulation of MAP kinase activity;GO:0043409|negative regulation of MAPK cascade;GO:0043410|positive regulation of MAPK cascade;GO:0045332|phospholipid translocation;GO:0045778|positive regulation of ossification;GO:0045779|negative regulation of bone resorption;GO:0045794|negative regulation of cell volume;GO:0045821|positive regulation of glycolytic process;GO:0046513|ceramide biosynthetic process;GO:0046931|pore complex assembly;GO:0048705|skeletal system morphogenesis;GO:0048873|homeostasis of number of cells within a tissue;GO:0050714|positive regulation of protein secretion;GO:0050830|defense response to Gram-positive bacterium;GO:0051209|release of sequestered calcium ion into cytosol;GO:0051495|positive regulation of cytoskeleton organization;GO:0051592|response to calcium ion;GO:0051602|response to electrical stimulus;GO:0051899|membrane depolarization;GO:0051901|positive regulation of mitochondrial depolarization;GO:0060079|excitatory postsynaptic potential;GO:0070230|positive regulation of lymphocyte apoptotic process;GO:0071359|cellular response to dsRNA;GO:0071407|cellular response to organic cyclic compound;GO:0071902|positive regulation of protein serine/threonine kinase activity;GO:0072593|reactive oxygen species metabolic process;GO:0097190|apoptotic signaling pathway;GO:0097191|extrinsic apoptotic signaling pathway;GO:0098655|cation transmembrane transport;GO:0099161|regulation of presynaptic dense core granule exocytosis;GO:1904172|positive regulation of bleb assembly;GO:1904669|ATP export;","GO:0005639|integral component of nuclear inner membrane;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005911|cell-cell junction;GO:0009897|external side of plasma membrane;GO:0016020|membrane;GO:0031594|neuromuscular junction;GO:0032059|bleb;GO:0032991|protein-containing complex;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0045121|membrane raft;GO:0045202|synapse;GO:0098794|postsynapse;","GO:0000287|magnesium ion binding;GO:0001530|lipopolysaccharide binding;GO:0001614|purinergic nucleotide receptor activity;GO:0004931|extracellularly ATP-gated cation channel activity;GO:0005102|signaling receptor binding;GO:0005507|copper ion binding;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0008270|zinc ion binding;GO:0015267|channel activity;GO:0038023|signaling receptor activity;GO:0042802|identical protein binding;GO:0043539|protein serine/threonine kinase activator activity;GO:0097110|scaffold protein binding;","K05220","P2RX7; P2X purinoceptor 7"]
["ENSRNOG00000055305",313,20.13542715,782,50.48737425,0.398821041,-1.32618657,{"v":2.22983E-47,"d":"2.23E-47"},{"v":6.88763e-47,"d":"6.89E-47"},"down","yes","Parvb","protein_coding","chr7:115360261-115445766:+","gi|198041989|ref|NP_001128252.1|",1535,0,"beta-parvin [Rattus norvegicus]","gi|672060157|ref|XM_006241409.2|",2915,0,"PREDICTED: Rattus norvegicus parvin, beta (Parvb), transcript variant X5, mRNA","Q9ES46",590,0,"Beta-parvin",".",".",".",".","pfam00307","CH","Calponin homology (CH) domain. The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.","GO:0007163|establishment or maintenance of cell polarity;GO:0030031|cell projection assembly;GO:0030032|lamellipodium assembly;GO:0031532|actin cytoskeleton reorganization;GO:0034446|substrate adhesion-dependent cell spreading;GO:0071963|establishment or maintenance of cell polarity regulating cell shape;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005925|focal adhesion;GO:0015629|actin cytoskeleton;GO:0030027|lamellipodium;","GO:0003779|actin binding;","K06275","PARV; parvin"]
["ENSRNOG00000061739",6,0.385982629,196,12.65412449,0.030502516,-5.034927963,{"v":2.46062e-47,"d":"2.46E-47"},{"v":7.5923e-47,"d":"7.59E-47"},"down","yes","Klrk1","protein_coding","chr4:163081927-163092459:-","gi|564348312|ref|XP_006237135.1|",1238,{"v":5e-162,"d":"5.00E-162"},"PREDICTED: NKG2-D type II integral membrane protein isoform X2 [Rattus norvegicus]","gi|672051172|ref|XM_006237073.2|",2340,0,"PREDICTED: Rattus norvegicus killer cell lectin-like receptor subfamily K, member 1 (Klrk1), transcript variant X1, mRNA","O70215",450,{"v":1e-151,"d":"1.00E-151"},"NKG2-D type II integral membrane protein",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0002223|stimulatory C-type lectin receptor signaling pathway;GO:0002250|adaptive immune response;GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target;GO:0030101|natural killer cell activation;GO:0030154|cell differentiation;GO:0030887|positive regulation of myeloid dendritic cell activation;GO:0032729|positive regulation of interferon-gamma production;GO:0034260|negative regulation of GTPase activity;GO:0042267|natural killer cell mediated cytotoxicity;GO:0043065|positive regulation of apoptotic process;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;GO:0050830|defense response to Gram-positive bacterium;GO:0071222|cellular response to lipopolysaccharide;GO:2000502|negative regulation of natural killer cell chemotaxis;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0005515|protein binding;GO:0019900|kinase binding;GO:0030246|carbohydrate binding;GO:0032394|MHC class Ib receptor activity;GO:0038023|signaling receptor activity;GO:0042288|MHC class I protein binding;GO:0042802|identical protein binding;","K06728","KLRK1, CD314; killer cell lectin-like receptor subfamily K member 1"]
["ENSRNOG00000017933",331,21.29337504,809,52.23054446,0.407680511,-1.294489105,{"v":3.20204e-47,"d":"3.20E-47"},{"v":9.86931e-47,"d":"9.87E-47"},"down","yes","Ccdc3","protein_coding","chr17:73035045-73135337:-","gi|392334002|ref|XP_001071191.3|",1371,{"v":6e-180,"d":"6.00E-180"},"PREDICTED: coiled-coil domain-containing protein 3 [Rattus norvegicus]","gi|672082550|ref|XM_574081.6|",2661,0,"PREDICTED: Rattus norvegicus coiled-coil domain containing 3 (Ccdc3), mRNA","Q9D6Y1",517,{"v":2E-175,"d":"2.00E-175"},"Coiled-coil domain-containing protein 3",".",".",".",".","pfam07321","YscO","Type III secretion protein YscO. This family contains the bacterial type III secretion protein YscO, which is approximately 150 residues long. YscO has been shown to be required for high-level expression and secretion of the anti-host proteins V antigen and Yops in Yersinia pestis.","GO:0010629|negative regulation of gene expression;GO:0010804|negative regulation of tumor necrosis factor-mediated signaling pathway;GO:0045600|positive regulation of fat cell differentiation;GO:0045833|negative regulation of lipid metabolic process;GO:0046889|positive regulation of lipid biosynthetic process;GO:0051055|negative regulation of lipid biosynthetic process;","GO:0005576|extracellular region;GO:0005783|endoplasmic reticulum;",".",".","."]
["ENSRNOG00000009862",9,0.578973944,203,13.10605751,0.044176057,-4.500591535,{"v":3.78065E-47,"d":"3.78E-47"},{"v":1.16402e-46,"d":"1.16E-46"},"down","yes","Olfm1","protein_coding","chr3:11520729-11558239:+","gi|17865343|ref|NP_446025.1|",2639,0,"noelin precursor [Rattus norvegicus]","gi|17865342|ref|NM_053573.1|",2753,0,"Rattus norvegicus olfactomedin 1 (Olfm1), mRNA","Q62609",1021,0,"Noelin",".",".",".",".","pfam02191","OLF","Olfactomedin-like domain.","GO:0003190|atrioventricular valve formation;GO:0007399|nervous system development;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010718|positive regulation of epithelial to mesenchymal transition;GO:0023041|neuronal signal transduction;GO:0030516|regulation of axon extension;GO:0043065|positive regulation of apoptotic process;GO:0060317|cardiac epithelial to mesenchymal transition;GO:1902003|regulation of amyloid-beta formation;GO:1902430|negative regulation of amyloid-beta formation;GO:2001223|negative regulation of neuron migration;","GO:0005615|extracellular space;GO:0005783|endoplasmic reticulum;GO:0030424|axon;GO:0032281|AMPA glutamate receptor complex;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0044295|axonal growth cone;GO:0097060|synaptic membrane;GO:0098978|glutamatergic synapse;GO:0099243|extrinsic component of synaptic membrane;","GO:0001540|amyloid-beta binding;GO:0042802|identical protein binding;","K25444","OLFM1; noelin"]
["ENSRNOG00000068695",42,2.701878404,291,18.78750116,0.143812548,-2.797738539,{"v":3.98724E-47,"d":"3.99E-47"},{"v":1.22696e-46,"d":"1.23E-46"},"down","yes","Diras3","protein_coding","chr6:130524742-130530825:-","gi|62651466|ref|XP_345726.2|",1033,{"v":7e-129,"d":"7.00E-129"},"PREDICTED: ras-related protein Rap-2a-like [Rattus norvegicus]","gi|672021163|ref|XM_001071789.4|",2947,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102554678 (LOC102554678), transcript variant X1, mRNA","Q5R988",180,{"v":1e-49,"d":"1.00E-49"},"Ras-related protein Rap-2a",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.",".",".",".",".","."]
["ENSRNOG00000018839",24,1.543930516,245,15.81765562,0.09760805,-3.356856058,{"v":4.64143e-47,"d":"4.64E-47"},{"v":1.4275e-46,"d":"1.43E-46"},"down","yes","Ntrk2","protein_coding","chr17:5559043-5869136:-","gi|253683488|ref|NP_001156640.1|",2434,0,"BDNF/NT-3 growth factors receptor isoform 2 precursor [Rattus norvegicus]","gi|402534544|ref|NM_001163168.2|",6931,0,"Rattus norvegicus neurotrophic tyrosine kinase, receptor, type 2 (Ntrk2), transcript variant 2, mRNA","Q63604",923,0,"BDNF/NT-3 growth factors receptor",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0001570|vasculogenesis;GO:0001764|neuron migration;GO:0006954|inflammatory response;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007178|transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0007275|multicellular organism development;GO:0007528|neuromuscular junction development;GO:0007568|aging;GO:0007612|learning;GO:0007616|long-term memory;GO:0007623|circadian rhythm;GO:0007631|feeding behavior;GO:0008284|positive regulation of cell proliferation;GO:0009416|response to light stimulus;GO:0010628|positive regulation of gene expression;GO:0010976|positive regulation of neuron projection development;GO:0010996|response to auditory stimulus;GO:0014047|glutamate secretion;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0019222|regulation of metabolic process;GO:0019227|neuronal action potential propagation;GO:0021954|central nervous system neuron development;GO:0021987|cerebral cortex development;GO:0022011|myelination in peripheral nervous system;GO:0030182|neuron differentiation;GO:0031547|brain-derived neurotrophic factor receptor signaling pathway;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0033674|positive regulation of kinase activity;GO:0035584|calcium-mediated signaling using intracellular calcium source;GO:0038179|neurotrophin signaling pathway;GO:0042490|mechanoreceptor differentiation;GO:0043087|regulation of GTPase activity;GO:0043408|regulation of MAPK cascade;GO:0043410|positive regulation of MAPK cascade;GO:0043524|negative regulation of neuron apoptotic process;GO:0046548|retinal rod cell development;GO:0046777|protein autophosphorylation;GO:0046928|regulation of neurotransmitter secretion;GO:0048709|oligodendrocyte differentiation;GO:0048935|peripheral nervous system neuron development;GO:0050772|positive regulation of axonogenesis;GO:0050773|regulation of dendrite development;GO:0051896|regulation of protein kinase B signaling;GO:0051965|positive regulation of synapse assembly;GO:0051968|positive regulation of synaptic transmission, glutamatergic;GO:0060041|retina development in camera-type eye;GO:0060291|long-term synaptic potentiation;GO:0071230|cellular response to amino acid stimulus;GO:0071356|cellular response to tumor necrosis factor;GO:0099183|trans-synaptic signaling by BDNF, modulating synaptic transmission;GO:0099551|trans-synaptic signaling by neuropeptide, modulating synaptic transmission;GO:1902430|negative regulation of amyloid-beta formation;GO:1990090|cellular response to nerve growth factor stimulus;GO:1990416|cellular response to brain-derived neurotrophic factor stimulus;GO:2000324|positive regulation of glucocorticoid receptor signaling pathway;GO:2000811|negative regulation of anoikis;","GO:0000139|Golgi membrane;GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005769|early endosome;GO:0005791|rough endoplasmic reticulum;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0014069|postsynaptic density;GO:0030424|axon;GO:0030425|dendrite;GO:0030426|growth cone;GO:0031901|early endosome membrane;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0043197|dendritic spine;GO:0043204|perikaryon;GO:0043235|receptor complex;GO:0043679|axon terminus;GO:0045211|postsynaptic membrane;GO:0048471|perinuclear region of cytoplasm;GO:0048786|presynaptic active zone;GO:0060076|excitatory synapse;GO:0098794|postsynapse;GO:0098978|glutamatergic synapse;","GO:0002020|protease binding;GO:0004675|transmembrane receptor protein serine/threonine kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0005030|neurotrophin receptor activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0030971|receptor tyrosine kinase binding;GO:0042803|protein homodimerization activity;GO:0043121|neurotrophin binding;GO:0048403|brain-derived neurotrophic factor binding;GO:0060175|brain-derived neurotrophic factor-activated receptor activity;","K04360","NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2 [EC:2.7.10.1]"]
["ENSRNOG00000058940",187,12.02979194,574,37.05850744,0.324616202,-1.623193086,{"v":5.14597e-47,"d":"5.15E-47"},{"v":1.58182E-46,"d":"1.58E-46"},"down","yes","Rab11fip1","protein_coding","chr16:64884676-64917491:+","gi|308522754|ref|NP_001178484.1|",5096,0,"rab11 family-interacting protein 1 isoform 1 [Rattus norvegicus]","gi|308522753|ref|NM_001191555.1|",7848,0,"Rattus norvegicus RAB11 family interacting protein 1 (class I) (Rab11fip1), transcript variant 1, mRNA","Q6WKZ4",1142,0,"Rab11 family-interacting protein 1",".",".",".",".","pfam09457","RBD-FIP","FIP domain. The FIP domain is the Rab11-binding domain (RBD) at the C-terminus of a family of Rab11-interacting proteins (FIPs). The Rab proteins constitute the largest family of small GTPases (>60 members in mammals). Among them Rab11 is a well characterized regulator of endocytic and recycling pathways. Rab11 associates with a broad range of post-Golgi organelles, including recycling endosomes.","GO:0015031|protein transport;GO:0045055|regulated exocytosis;GO:0070164|negative regulation of adiponectin secretion;","GO:0005768|endosome;GO:0005829|cytosol;GO:0016020|membrane;GO:0030670|phagocytic vesicle membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0055037|recycling endosome;","GO:0031267|small GTPase binding;","K12484","RAB11FIP1_2_5; Rab11 family-interacting protein 1/2/5"]
["ENSRNOG00000008196",242,15.56796604,666,42.99819853,0.36206089,-1.465695749,{"v":5.64039e-47,"d":"5.64E-47"},{"v":1.731E-46,"d":"1.73E-46"},"down","yes","Parp12","protein_coding","chr4:67839237-67883685:-","gi|392339871|ref|XP_003753925.1|",3495,0,"PREDICTED: poly [ADP-ribose] polymerase 12 isoform X1 [Rattus norvegicus]","gi|672049407|ref|XM_003749716.3|",2870,0,"PREDICTED: Rattus norvegicus poly (ADP-ribose) polymerase family, member 12 (Parp12), transcript variant X1, mRNA","Q8BZ20",1247,0,"Poly [ADP-ribose] polymerase 12",".",".",".",".","pfam00644","PARP","Poly(ADP-ribose) polymerase catalytic domain. Poly(ADP-ribose) polymerase catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The carboxyl-terminal region is the most highly conserved region of the protein. Experiments have shown that a carboxyl 40 kDa fragment is still catalytically active.","GO:0008150|biological_process;GO:0070213|protein auto-ADP-ribosylation;","GO:0005575|cellular_component;","GO:0003674|molecular_function;GO:0003950|NAD+ ADP-ribosyltransferase activity;GO:0046872|metal ion binding;GO:1990404|protein ADP-ribosylase activity;","K15259","PARP7S; poly [ADP-ribose] polymerase 7/11/12/13 [EC:2.4.2.30]"]
["ENSRNOG00000036677",146,9.392243975,501,32.34549169,0.290372583,-1.784022854,{"v":6.897e-47,"d":"6.90E-47"},{"v":2.11211e-46,"d":"2.11E-46"},"down","yes","Slc16a3","protein_coding","chr10:106212778-106222562:+","gi|13540632|ref|NP_110461.1|",2150,0,"monocarboxylate transporter 4 [Rattus norvegicus]","gi|672070355|ref|XM_008768514.1|",2816,0,"PREDICTED: Rattus norvegicus solute carrier family 16 (monocarboxylate transporter), member 3 (Slc16a3), transcript variant X6, mRNA","O35910",832,0,"Monocarboxylate transporter 4",".",".",".",".","pfam07690","MFS_1","Major Facilitator Superfamily.","GO:0015718|monocarboxylic acid transport;GO:0035879|plasma membrane lactate transport;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0016328|lateral plasma membrane;GO:0031965|nuclear membrane;GO:0098688|parallel fiber to Purkinje cell synapse;GO:0099061|integral component of postsynaptic density membrane;","GO:0008028|monocarboxylic acid transmembrane transporter activity;GO:0015129|lactate transmembrane transporter activity;GO:0015293|symporter activity;","K08180","SLC16A3; MFS transporter, MCT family, solute carrier family 16 (monocarboxylic acid transporters), member 3"]
["ENSRNOG00000001628",8,0.514643505,199,12.84781007,0.040056905,-4.64180524,{"v":7.87973e-47,"d":"7.88E-47"},{"v":2.40919e-46,"d":"2.41E-46"},"down","yes","Pcp4","protein_coding","chr11:35800713-35861725:+","gi|395627633|ref|NP_001257467.1|",492,{"v":5e-60,"d":"5.00E-60"},"Purkinje cell protein 4 LPI isoform [Rattus norvegicus]","gi|730229382|ref|NM_001270538.2|",698,0,"Rattus norvegicus Purkinje cell protein 4 (Pcp4), transcript variant 2, mRNA","P63055",84.7,{"v":1e-19,"d":"1.00E-19"},"Calmodulin regulator protein PCP4",".",".",".",".","pfam13239","2TM","2TM domain. This short region contains two transmembrane alpha helices that are found associated with a wide range of other domains. This domain may be involved in cell lysis or peptidoglycan turnover.","GO:0001649|osteoblast differentiation;GO:0006469|negative regulation of protein kinase activity;GO:0006970|response to osmotic stress;GO:0010976|positive regulation of neuron projection development;GO:0033603|positive regulation of dopamine secretion;GO:0043524|negative regulation of neuron apoptotic process;GO:0045666|positive regulation of neuron differentiation;GO:0099004|calmodulin dependent kinase signaling pathway;GO:1904009|cellular response to monosodium glutamate;","GO:0005737|cytoplasm;GO:0005883|neurofilament;GO:0030424|axon;GO:0032991|protein-containing complex;GO:0043005|neuron projection;","GO:0003723|RNA binding;GO:0005509|calcium ion binding;GO:0005516|calmodulin binding;",".","."]
["ENSRNOG00000009131",330,21.2290446,803,51.8431733,0.409485825,-1.288114583,{"v":1.53801E-46,"d":"1.54E-46"},{"v":4.68733e-46,"d":"4.69E-46"},"down","yes","Zc3h12a","protein_coding","chr5:137376564-137385351:-","gi|117940029|ref|NP_001071139.1|",2954,0,"ribonuclease ZC3H12A [Rattus norvegicus]","gi|117940028|ref|NM_001077671.1|",2542,0,"Rattus norvegicus zinc finger CCCH type containing 12A (Zc3h12a), mRNA","A0JPN4",1142,0,"Endoribonuclease ZC3H12A",".",".",".",".","pfam11977","RNase_Zc3h12a","Zc3h12a-like Ribonuclease NYN domain. This domain is found in the Zc3h12a protein which has shown to be a ribonuclease that controls the stability of a set of inflammatory genes. It has been suggested that this domain belongs to the PIN domain superfamily. This domain has also been identified as part of the NYN domain family.","GO:0000294|nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay;GO:0001525|angiogenesis;GO:0001933|negative regulation of protein phosphorylation;GO:0002230|positive regulation of defense response to virus by host;GO:0002757|immune response-activating signal transduction;GO:0006915|apoptotic process;GO:0006954|inflammatory response;GO:0006974|cellular response to DNA damage stimulus;GO:0007399|nervous system development;GO:0010468|regulation of gene expression;GO:0010508|positive regulation of autophagy;GO:0010595|positive regulation of endothelial cell migration;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010656|negative regulation of muscle cell apoptotic process;GO:0010884|positive regulation of lipid storage;GO:0010942|positive regulation of cell death;GO:0016579|protein deubiquitination;GO:0030154|cell differentiation;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0032689|negative regulation of interferon-gamma production;GO:0032691|negative regulation of interleukin-1 beta production;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0034599|cellular response to oxidative stress;GO:0042149|cellular response to glucose starvation;GO:0042307|positive regulation of protein import into nucleus;GO:0043124|negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0044828|negative regulation by host of viral genome replication;GO:0045019|negative regulation of nitric oxide biosynthetic process;GO:0045600|positive regulation of fat cell differentiation;GO:0045766|positive regulation of angiogenesis;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050852|T cell receptor signaling pathway;GO:0051259|protein complex oligomerization;GO:0055118|negative regulation of cardiac muscle contraction;GO:0061014|positive regulation of mRNA catabolic process;GO:0061158|3'-UTR-mediated mRNA destabilization;GO:0071222|cellular response to lipopolysaccharide;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0090501|RNA phosphodiester bond hydrolysis;GO:0090502|RNA phosphodiester bond hydrolysis, endonucleolytic;GO:0090503|RNA phosphodiester bond hydrolysis, exonucleolytic;GO:0098586|cellular response to virus;GO:1900016|negative regulation of cytokine production involved in inflammatory response;GO:1900119|positive regulation of execution phase of apoptosis;GO:1900745|positive regulation of p38MAPK cascade;GO:1901223|negative regulation of NIK/NF-kappaB signaling;GO:1903003|positive regulation of protein deubiquitination;GO:1903799|negative regulation of production of miRNAs involved in gene silencing by miRNA;GO:1903936|cellular response to sodium arsenite;GO:1904637|cellular response to ionomycin;GO:1990869|cellular response to chemokine;GO:2000320|negative regulation of T-helper 17 cell differentiation;GO:2000379|positive regulation of reactive oxygen species metabolic process;GO:2000627|positive regulation of miRNA catabolic process;","GO:0000932|P-body;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005791|rough endoplasmic reticulum;GO:0005856|cytoskeleton;GO:0030867|rough endoplasmic reticulum membrane;GO:0032991|protein-containing complex;GO:0036464|cytoplasmic ribonucleoprotein granule;GO:0042406|extrinsic component of endoplasmic reticulum membrane;","GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003723|RNA binding;GO:0003729|mRNA binding;GO:0003730|mRNA 3'-UTR binding;GO:0004518|nuclease activity;GO:0004521|endoribonuclease activity;GO:0004532|exoribonuclease activity;GO:0004540|ribonuclease activity;GO:0004843|thiol-dependent ubiquitin-specific protease activity;GO:0035198|miRNA binding;GO:0035613|RNA stem-loop binding;GO:0035925|mRNA 3'-UTR AU-rich region binding;GO:0043022|ribosome binding;GO:0046872|metal ion binding;","K18668","ZC3H12, MCPIP; ribonuclease ZC3H12 [EC:3.1.-.-]"]
["ENSRNOG00000004516",390,25.08887089,894,57.71830253,0.434677906,-1.201981327,{"v":1.74205E-46,"d":"1.74E-46"},{"v":5.30352e-46,"d":"5.30E-46"},"down","yes","Itgbl1","protein_coding","chr15:100780184-101041733:+","gi|62945368|ref|NP_001017505.1|",2031,0,"integrin beta-like protein 1 precursor [Rattus norvegicus]","gi|62945367|ref|NM_001017505.1|",2288,0,"Rattus norvegicus integrin subunit beta like 1 (Itgbl1), mRNA","Q5PQQ8",786,0,"Integrin beta-like protein 1",".",".",".",".","pfam07974","EGF_2","EGF-like domain. This family contains EGF domains found in a variety of extracellular proteins.","GO:0007160|cell-matrix adhesion;GO:0007229|integrin-mediated signaling pathway;GO:0016477|cell migration;GO:0033627|cell adhesion mediated by integrin;","GO:0005576|extracellular region;GO:0005925|focal adhesion;GO:0008305|integrin complex;GO:0009986|cell surface;","GO:0005178|integrin binding;",".","."]
["ENSRNOG00000070316",7,0.450313067,195,12.58956263,0.035768762,-4.805156011,{"v":1.75477e-46,"d":"1.75E-46"},{"v":5.3394e-46,"d":"5.34E-46"},"down","yes","ENSRNOG00000070316","lncRNA","chr10:81259112-81261199:+","gi|119615141|gb|EAW94735.1|",198,{"v":4e-15,"d":"4.00E-15"},"hCG2042068, isoform CRA_d [Homo sapiens]","gi|354798630|gb|JN963131.1|",1284,0,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Hoxb6:tm1a(KOMP)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam15226","HPIP","HCF-1 beta-propeller-interacting protein family. HPIP is a small cellular polypeptide that binds to the beta-propeller domain of HCF-1. HPIP regulates HCF-1 activity by modulating its subcellular localisation. HCF-1 is a cellular protein required by VP16 to activate the herpes simplex virus- immediate-early genes. VP16 is a component of the viral tegument and, after release into the cell, binds to HCF-1 and translocates to the nucleus to form a complex with the POU domain protein Oct-1 and a VP16-responsive DNA sequence. HPIP-mediated export may provide the pool of cytoplasmic HCF-1 required for import of virion-derived VP16 into the nucleus.",".",".",".",".","."]
["ENSRNOG00000024917",5,0.321652191,190,12.26675333,0.026221461,-5.253108133,{"v":2.37977e-46,"d":"2.38E-46"},{"v":7.22957e-46,"d":"7.23E-46"},"down","yes","Flacc1","protein_coding","chr9:60315582-60343648:-","gi|62078935|ref|NP_001014123.1|",1666,0,"amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein homolog [Rattus norvegicus]","gi|62078934|ref|NM_001014101.1|",1315,0,"Rattus norvegicus amyotrophic lateral sclerosis 2 chromosome region, candidate 12 (Als2cr12), mRNA","Q6AY08",646,0,"Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein homolog",".",".",".",".","pfam02463","SMC_N","RecF/RecN/SMC N terminal domain. This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics.   This family also includes the RecF and RecN proteins that are involved in DNA metabolizm and recombination.",".","GO:0001520|outer dense fiber;GO:0005737|cytoplasm;GO:0031410|cytoplasmic vesicle;GO:0035686|sperm fibrous sheath;GO:0036126|sperm flagellum;",".","K25631","FLACC1, ALS2CR12; flagellum-associated coiled-coil domain-containing protein 1"]
["ENSRNOG00000010610",271,17.43354875,709,45.7743585,0.380858396,-1.392673395,{"v":2.48128e-46,"d":"2.48E-46"},{"v":7.53396e-46,"d":"7.53E-46"},"down","yes","Hpgd","protein_coding","chr16:33986266-34024228:-","gi|40538858|ref|NP_077366.2|",1274,{"v":1e-170,"d":"1.00E-170"},"15-hydroxyprostaglandin dehydrogenase [NAD(+)] [Rattus norvegicus]","gi|40538857|ref|NM_024390.2|",1666,0,"Rattus norvegicus hydroxyprostaglandin dehydrogenase 15 (NAD) (Hpgd), mRNA","O08699",495,{"v":4e-172,"d":"4.00E-172"},"15-hydroxyprostaglandin dehydrogenase [NAD(+)]","VC1591",107,{"v":4e-25,"d":"4.00E-25"},"COG1028","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.","GO:0001822|kidney development;GO:0006693|prostaglandin metabolic process;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0007565|female pregnancy;GO:0007567|parturition;GO:0030728|ovulation;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0043065|positive regulation of apoptotic process;GO:0045471|response to ethanol;GO:0045786|negative regulation of cell cycle;GO:0070493|thrombin-activated receptor signaling pathway;GO:0097070|ductus arteriosus closure;GO:1904707|positive regulation of vascular smooth muscle cell proliferation;GO:1905828|regulation of prostaglandin catabolic process;","GO:0005615|extracellular space;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016323|basolateral plasma membrane;","GO:0004957|prostaglandin E receptor activity;GO:0016404|15-hydroxyprostaglandin dehydrogenase (NAD+) activity;GO:0016616|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0042802|identical protein binding;GO:0051287|NAD binding;GO:0070403|NAD+ binding;","K00069","HPGD; 15-hydroxyprostaglandin dehydrogenase (NAD) [EC:1.1.1.141]"]
["ENSRNOG00000027739",27,1.736921831,250,16.14046491,0.107612875,-3.216077402,{"v":2.60835e-46,"d":"2.61E-46"},{"v":7.90716E-46,"d":"7.91E-46"},"down","yes","Cndp1","protein_coding","chr18:77984907-78007765:-","gi|56090459|ref|NP_001007688.1|",2639,0,"beta-Ala-His dipeptidase [Rattus norvegicus]","gi|672083414|ref|XM_008772135.1|",2620,0,"PREDICTED: Rattus norvegicus carnosine dipeptidase 1 (metallopeptidase M20 family) (Cndp1), transcript variant X2, mRNA","Q66HG3",1021,0,"Beta-Ala-His dipeptidase","SPBC1198.08",429,{"v":7e-140,"d":"7.00E-140"},"COG0624","pfam01546","Peptidase_M20","Peptidase family M20/M25/M40. This family includes a range of zinc metallopeptidases belonging to several families in the peptidase classification. Family M20 are Glutamate carboxypeptidases. Peptidase family M25 contains X-His dipeptidases.","GO:0006508|proteolysis;GO:0032268|regulation of cellular protein metabolic process;","GO:0005829|cytosol;","GO:0004180|carboxypeptidase activity;GO:0008233|peptidase activity;GO:0016805|dipeptidase activity;GO:0046872|metal ion binding;GO:0070573|metallodipeptidase activity;","K05604","CNDP1; beta-Ala-His dipeptidase [EC:3.4.13.20]"]
["ENSRNOG00000045992",58,3.731165415,324,20.91804253,0.178370677,-2.487049627,{"v":3.26201e-46,"d":"3.26E-46"},{"v":9.85732E-46,"d":"9.86E-46"},"down","yes","ENSRNOG00000045992","protein_coding","chrX:27091778-27116549:+","gi|149035901|gb|EDL90568.1|",5084,0,"rCG49623 [Rattus norvegicus]","gi|155369699|ref|NM_001101009.1|",3381,0,"Rattus norvegicus toll-like receptor 8 (Tlr8), mRNA","P58682",1753,0,"Toll-like receptor 8","SPBC19C7.03_1",57,6e-07,"COG4886","pfam01582","TIR","TIR domain. The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.","GO:0001932|regulation of protein phosphorylation;GO:0002224|toll-like receptor signaling pathway;GO:0002755|MyD88-dependent toll-like receptor signaling pathway;GO:0006954|inflammatory response;GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0009615|response to virus;GO:0032695|negative regulation of interleukin-12 production;GO:0032727|positive regulation of interferon-alpha production;GO:0032728|positive regulation of interferon-beta production;GO:0032729|positive regulation of interferon-gamma production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0034158|toll-like receptor 8 signaling pathway;GO:0045087|innate immune response;GO:0045089|positive regulation of innate immune response;GO:0051607|defense response to virus;GO:0071260|cellular response to mechanical stimulus;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0003677|DNA binding;GO:0003725|double-stranded RNA binding;GO:0003727|single-stranded RNA binding;GO:0003953|NAD+ nucleosidase activity;GO:0004888|transmembrane signaling receptor activity;GO:0038187|pattern recognition receptor activity;GO:0042802|identical protein binding;","K10170","TLR8, CD288; toll-like receptor 8"]
["ENSRNOG00000002032",499,32.10088865,1052,67.91907636,0.472634352,-1.081203603,{"v":3.64029e-46,"d":"3.64E-46"},{"v":1.09772E-45,"d":"1.10E-45"},"down","yes","Ifngr2","protein_coding","chr11:30779733-30798005:+","gi|157819839|ref|NP_001101783.1|",1563,0,"interferon gamma receptor 2 precursor [Rattus norvegicus]","gi|157819838|ref|NM_001108313.1|",2610,0,"Rattus norvegicus interferon gamma receptor 2 (Ifngr2), mRNA","P38484",355,{"v":6e-113,"d":"6.00E-113"},"Interferon gamma receptor 2",".",".",".",".","pfam01108","Tissue_fac","Tissue factor. This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.","GO:0001774|microglial cell activation;GO:0019221|cytokine-mediated signaling pathway;GO:0051607|defense response to virus;GO:1904783|positive regulation of NMDA glutamate receptor activity;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004896|cytokine receptor activity;","K05133","IFNGR2; interferon gamma receptor 2"]
["ENSRNOG00000022893",28,1.801252269,252,16.26958863,0.110712834,-3.175105621,{"v":3.72296e-46,"d":"3.72E-46"},{"v":1.12146E-45,"d":"1.12E-45"},"down","yes","Rimbp2","protein_coding","chr12:27747980-27956763:+","gi|672072846|ref|XP_008767413.1|",6010,0,"PREDICTED: RIMS-binding protein 2 isoform X2 [Rattus norvegicus]","gi|672072849|ref|XM_008769193.1|",3807,0,"PREDICTED: Rattus norvegicus RIMS binding protein 2 (Rimbp2), transcript variant X7, mRNA","Q8QFX1",1634,0,"RIMS-binding protein 2",".",".",".",".","pfam14604","SH3_9","Variant SH3 domain.","GO:0007274|neuromuscular synaptic transmission;","GO:0005886|plasma membrane;GO:0098831|presynaptic active zone cytoplasmic component;","GO:0005515|protein binding;","K17591","RIMBP2; RIMS-binding protein 2"]
["ENSRNOG00000048782",0,0.032165219,232,14.97835144,0.002147447,-8.863161614,{"v":4.08198e-46,"d":"4.08E-46"},{"v":1.22832E-45,"d":"1.23E-45"},"down","yes","Wnt7a","protein_coding","chr4:123863108-123908981:-","gi|291219904|ref|NP_001093943.1|",1804,0,"protein Wnt-7a precursor [Rattus norvegicus]","gi|291219903|ref|NM_001100473.1|",3150,0,"Rattus norvegicus wingless-type MMTV integration site family, member 7A (Wnt7a), mRNA","P24383",696,0,"Protein Wnt-7a",".",".",".",".","pfam00110","wnt","wnt family. Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.","GO:0000578|embryonic axis specification;GO:0001502|cartilage condensation;GO:0001525|angiogenesis;GO:0002062|chondrocyte differentiation;GO:0007269|neurotransmitter secretion;GO:0008284|positive regulation of cell proliferation;GO:0009953|dorsal/ventral pattern formation;GO:0010595|positive regulation of endothelial cell migration;GO:0010628|positive regulation of gene expression;GO:0014719|skeletal muscle satellite cell activation;GO:0014834|skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration;GO:0016055|Wnt signaling pathway;GO:0021707|cerebellar granule cell differentiation;GO:0021846|cell proliferation in forebrain;GO:0022009|central nervous system vasculogenesis;GO:0030010|establishment of cell polarity;GO:0030182|neuron differentiation;GO:0030326|embryonic limb morphogenesis;GO:0031133|regulation of axon diameter;GO:0032270|positive regulation of cellular protein metabolic process;GO:0032355|response to estradiol;GO:0035019|somatic stem cell population maintenance;GO:0035115|embryonic forelimb morphogenesis;GO:0035116|embryonic hindlimb morphogenesis;GO:0035136|forelimb morphogenesis;GO:0035137|hindlimb morphogenesis;GO:0035313|wound healing, spreading of epidermal cells;GO:0035567|non-canonical Wnt signaling pathway;GO:0042060|wound healing;GO:0042127|regulation of cell proliferation;GO:0042733|embryonic digit morphogenesis;GO:0043066|negative regulation of apoptotic process;GO:0043589|skin morphogenesis;GO:0043627|response to estrogen;GO:0045165|cell fate commitment;GO:0045167|asymmetric protein localization involved in cell fate determination;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046330|positive regulation of JNK cascade;GO:0048103|somatic stem cell division;GO:0048608|reproductive structure development;GO:0048705|skeletal system morphogenesis;GO:0048864|stem cell development;GO:0050768|negative regulation of neurogenesis;GO:0050770|regulation of axonogenesis;GO:0050808|synapse organization;GO:0051216|cartilage development;GO:0051965|positive regulation of synapse assembly;GO:0060054|positive regulation of epithelial cell proliferation involved in wound healing;GO:0060065|uterus development;GO:0060066|oviduct development;GO:0060070|canonical Wnt signaling pathway;GO:0060071|Wnt signaling pathway, planar cell polarity pathway;GO:0060173|limb development;GO:0060997|dendritic spine morphogenesis;GO:0061038|uterus morphogenesis;GO:0062009|secondary palate development;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0099175|regulation of postsynapse organization;GO:1904891|positive regulation of excitatory synapse assembly;GO:1905606|regulation of presynapse assembly;GO:2000300|regulation of synaptic vesicle exocytosis;GO:2000463|positive regulation of excitatory postsynaptic potential;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0009986|cell surface;GO:0031012|extracellular matrix;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098793|presynapse;GO:0098978|glutamatergic synapse;","GO:0005102|signaling receptor binding;GO:0005109|frizzled binding;GO:0005125|cytokine activity;GO:0005515|protein binding;GO:0048018|receptor ligand activity;","K00572","WNT7; wingless-type MMTV integration site family, member 7"]
["ENSRNOG00000014125",27,1.736921831,249,16.07590305,0.108045055,-3.210295049,{"v":4.62654e-46,"d":"4.63E-46"},{"v":1.39145E-45,"d":"1.39E-45"},"down","yes","Evi2b","protein_coding","chr10:64471505-64481560:-","gi|407228403|ref|NP_001258411.1|",1428,0,"protein EVI2B precursor [Rattus norvegicus]","gi|281371508|gb|AC123294.3|",2912,0,"Rattus norvegicus BAC CH230-333F9 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q8VD58",377,{"v":4e-118,"d":"4.00E-118"},"Protein EVI2B",".",".",".",".","pfam12051","DUF3533","Protein of unknown function (DUF3533). This family of transmembrane proteins is functionally uncharacterized. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 393 to 772 amino acids in length.","GO:0030854|positive regulation of granulocyte differentiation;GO:0045660|positive regulation of neutrophil differentiation;GO:2000035|regulation of stem cell division;","GO:0016021|integral component of membrane;",".","K16854","EVI2B, CD361; ecotropic viral integration site 2B protein"]
["ENSRNOG00000005342",77,4.95344374,364,23.50051691,0.210780204,-2.246188719,{"v":4.82686e-46,"d":"4.83E-46"},{"v":1.45093e-45,"d":"1.45E-45"},"down","yes","Rassf5","protein_coding","chr13:42637549-42703024:-","gi|25742807|ref|NP_062238.1|",1904,0,"ras association domain-containing protein 5 [Rattus norvegicus]","gi|2459832|gb|AF002251.1|AF002251",3406,0,"Rattus norvegicus Maxp1 mRNA, complete cds","O35141",738,0,"Ras association domain-containing protein 5",".",".",".",".","pfam00788","RA","Ras association (RalGDS/AF-6) domain. RasGTP effectors (in cases of AF6, canoe and RalGDS); putative RasGTP effectors in other cases. Recent evidence (not yet in MEDLINE) shows that some RA domains do NOT bind RasGTP. Predicted structure similar to that determined, and that of the RasGTP-binding domain of Raf kinase.","GO:0006915|apoptotic process;GO:0007165|signal transduction;GO:0008285|negative regulation of cell proliferation;GO:0031398|positive regulation of protein ubiquitination;GO:0035556|intracellular signal transduction;GO:0042981|regulation of apoptotic process;GO:1900180|regulation of protein localization to nucleus;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005874|microtubule;","GO:0031267|small GTPase binding;GO:0042802|identical protein binding;GO:0046872|metal ion binding;","K08015","RASSF5, RAPL; Ras association domain-containing protein 5"]
["ENSRNOG00000058752",42,2.701878404,286,18.46469186,0.146326753,-2.772734533,{"v":6.19734e-46,"d":"6.20E-46"},{"v":1.86093e-45,"d":"1.86E-45"},"down","yes","Popdc2","protein_coding","chr11:62374759-62390756:-","gi|40018594|ref|NP_954544.1|",1782,0,"popeye domain-containing protein 2 [Rattus norvegicus]","gi|40018593|ref|NM_199113.1|",2224,0,"Rattus norvegicus popeye domain containing 2 (Popdc2), mRNA","Q9ES82",605,0,"Popeye domain-containing protein 2",".",".",".",".","pfam04831","Popeye","Popeye protein conserved region. The function of Popeye proteins is not well understood. They are predominantly expressed in cardiac and skeletal muscle. This family represents a conserved region which includes three potential transmembrane domains.","GO:0002027|regulation of heart rate;GO:0007507|heart development;GO:0007519|skeletal muscle tissue development;GO:0042391|regulation of membrane potential;GO:0051146|striated muscle cell differentiation;GO:0060931|sinoatrial node cell development;","GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0042383|sarcolemma;","GO:0030552|cAMP binding;",".","."]
["ENSRNOG00000007918",53,3.409513224,311,20.07873835,0.169807144,-2.558030935,{"v":8.38718e-46,"d":"8.39E-46"},{"v":2.51453e-45,"d":"2.51E-45"},"down","yes","Tbxas1","protein_coding","chr4:67665007-67837096:+","gi|6981634|ref|NP_036819.1|",2590,0,"thromboxane-A synthase [Rattus norvegicus]","gi|6981633|ref|NM_012687.1|",1813,0,"Rattus norvegicus thromboxane A synthase 1 (Tbxas1), mRNA","P49430",998,0,"Thromboxane-A synthase","VNG0422G",126,{"v":1e-30,"d":"1.00E-30"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0001516|prostaglandin biosynthetic process;GO:0006690|icosanoid metabolic process;GO:0030644|cellular chloride ion homeostasis;GO:0045471|response to ethanol;GO:0045907|positive regulation of vasoconstriction;GO:0070542|response to fatty acid;","GO:0005575|cellular_component;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0004497|monooxygenase activity;GO:0004796|thromboxane-A synthase activity;GO:0005506|iron ion binding;GO:0016705|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0020037|heme binding;GO:0036134|12-hydroxyheptadecatrienoic acid synthase activity;","K01832","TBXAS1, CYP5A; thromboxane-A synthase [EC:5.3.99.5]"]
["ENSRNOG00000057713",327,21.03605329,793,51.19755471,0.410880039,-1.28321085,{"v":1.01375e-45,"d":"1.01E-45"},{"v":3.03134e-45,"d":"3.03E-45"},"down","yes","Cav2","protein_coding","chr4:45616712-45624244:+","gi|38322757|gb|AAR16307.1|",851,{"v":5e-105,"d":"5.00E-105"},"caveolin 2 [Rattus norvegicus]","gi|298905441|emb|FQ209775.1|",2625,0,"Rattus norvegicus TL0ABA3YJ04 mRNA sequence","Q2IBC5",330,{"v":8e-106,"d":"8.00E-106"},"Caveolin-2",".",".",".",".","pfam01146","Caveolin","Caveolin. All three known Caveolin forms have the FEDVIAEP caveolin 'signature motif' within their hydrophilic N-terminal domain. Caveolin 2 (Cav-2) is co-localized and co-expressed with Cav-1/VIP21, forms heterodimers with it and needs Cav-1 for proper membrane localisation. Cav-3 has greater protein sequence similarity to Cav-1 than to Cav-2. Cellular processes caveolins are involved in include vesicular transport, cholesterol homeostasis, signal transduction, and tumor suppression.","GO:0001937|negative regulation of endothelial cell proliferation;GO:0001938|positive regulation of endothelial cell proliferation;GO:0006906|vesicle fusion;GO:0007005|mitochondrion organization;GO:0007029|endoplasmic reticulum organization;GO:0007088|regulation of mitotic nuclear division;GO:0007268|chemical synaptic transmission;GO:0008285|negative regulation of cell proliferation;GO:0008286|insulin receptor signaling pathway;GO:0016050|vesicle organization;GO:0019065|receptor-mediated endocytosis of virus by host cell;GO:0030154|cell differentiation;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0043410|positive regulation of MAPK cascade;GO:0043547|positive regulation of GTPase activity;GO:0044791|positive regulation by host of viral release from host cell;GO:0044794|positive regulation by host of viral process;GO:0048278|vesicle docking;GO:0048741|skeletal muscle fiber development;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0051480|regulation of cytosolic calcium ion concentration;GO:0060161|positive regulation of dopamine receptor signaling pathway;GO:0070836|caveola assembly;GO:0071711|basement membrane organization;GO:1900182|positive regulation of protein localization to nucleus;","GO:0000139|Golgi membrane;GO:0002080|acrosomal membrane;GO:0002095|caveolar macromolecular signaling complex;GO:0005635|nuclear envelope;GO:0005637|nuclear inner membrane;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005811|lipid droplet;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005901|caveola;GO:0005925|focal adhesion;GO:0009986|cell surface;GO:0016020|membrane;GO:0030133|transport vesicle;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0031410|cytoplasmic vesicle;GO:0032991|protein-containing complex;GO:0042383|sarcolemma;GO:0045121|membrane raft;GO:0045202|synapse;GO:0048471|perinuclear region of cytoplasm;","GO:0000149|SNARE binding;GO:0005515|protein binding;GO:0019901|protein kinase binding;GO:0019905|syntaxin binding;GO:0030674|protein binding, bridging;GO:0031435|mitogen-activated protein kinase kinase kinase binding;GO:0031748|D1 dopamine receptor binding;GO:0042803|protein homodimerization activity;GO:0046982|protein heterodimerization activity;GO:0051219|phosphoprotein binding;GO:0060090|molecular adaptor activity;GO:0097110|scaffold protein binding;","K12958","CAV2; caveolin 2"]
["ENSRNOG00000031643",431,27.72641886,949,61.26920481,0.452534335,-1.143900837,{"v":1.23687E-45,"d":"1.24E-45"},{"v":3.68884e-45,"d":"3.69E-45"},"down","yes","Dchs1","protein_coding","chr1:160104931-160124808:-","gi|242397499|ref|NP_001101014.2|",15495,0,"protocadherin-16 precursor [Rattus norvegicus]","gi|672037890|ref|XM_008759732.1|",10462,0,"PREDICTED: Rattus norvegicus dachsous cadherin-related 1 (Dchs1), transcript variant X2, mRNA","D4ACX8",5937,0,"Protocadherin-16",".",".",".",".","pfam00028","Cadherin","Cadherin domain.","GO:0000902|cell morphogenesis;GO:0001658|branching involved in ureteric bud morphogenesis;GO:0001822|kidney development;GO:0003007|heart morphogenesis;GO:0003183|mitral valve morphogenesis;GO:0003192|mitral valve formation;GO:0003273|cell migration involved in endocardial cushion formation;GO:0007043|cell-cell junction assembly;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007275|multicellular organism development;GO:0007389|pattern specification process;GO:0009653|anatomical structure morphogenesis;GO:0016339|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0016477|cell migration;GO:0021915|neural tube development;GO:0022008|neurogenesis;GO:0034332|adherens junction organization;GO:0035329|hippo signaling;GO:0036342|post-anal tail morphogenesis;GO:0043931|ossification involved in bone maturation;GO:0048565|digestive tract development;GO:0072006|nephron development;GO:0072137|condensed mesenchymal cell proliferation;GO:0072659|protein localization to plasma membrane;GO:0090102|cochlea development;GO:0098609|cell-cell adhesion;GO:0098742|cell-cell adhesion via plasma-membrane adhesion molecules;","GO:0005912|adherens junction;GO:0016021|integral component of membrane;GO:0016342|catenin complex;GO:0045177|apical part of cell;","GO:0005509|calcium ion binding;GO:0045296|cadherin binding;","K16507","DCHS1_2, PCDH16_23; protocadherin-16/23"]
["ENSRNOG00000030332",0,0.032165219,228,14.720104,0.002185122,-8.838070634,{"v":1.7517e-45,"d":"1.75E-45"},{"v":5.20797e-45,"d":"5.21E-45"},"down","yes","Ighg1","protein_coding","chr6:132389370-132393397:-","gi|56971338|gb|AAH88271.1|",1648,0,"Immunoglobulin heavy chain (gamma polypeptide) [Rattus norvegicus]","gi|62205065|gb|BC092584.1|",1089,0,"Rattus norvegicus Immunoglobulin heavy chain (gamma polypeptide), mRNA (cDNA clone MGC:108947 IMAGE:7384581), complete cds","P20759",636,0,"Ig gamma-1 chain C region",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.",".",".",".",".","."]
["ENSRNOG00000022640",19,1.222278326,225,14.52641842,0.084141754,-3.571034297,{"v":1.79682e-45,"d":"1.80E-45"},{"v":5.33657e-45,"d":"5.34E-45"},"down","yes","Siglec8","protein_coding","chr1:94093395-94103034:-","gi|149056112|gb|EDM07543.1|",2413,0,"rCG54314 [Rattus norvegicus]","gi|672013506|ref|XR_342908.2|",2436,0,"PREDICTED: Rattus norvegicus sialic acid binding Ig-like lectin 8 (Siglec8), transcript variant X1, misc_RNA","Q91Y57",726,0,"Sialic acid-binding Ig-like lectin 12",".",".",".",".","pfam08205","C2-set_2","CD80-like C2-set immunoglobulin domain. These domains belong to the immunoglobulin superfamily.","GO:0007155|cell adhesion;GO:0050728|negative regulation of inflammatory response;GO:0060101|negative regulation of phagocytosis, engulfment;","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0033691|sialic acid binding;GO:0048029|monosaccharide binding;",".","."]
["ENSRNOG00000010475",300,19.29913146,749,48.35683288,0.399098334,-1.325183837,{"v":2.10854e-45,"d":"2.11E-45"},{"v":6.25912e-45,"d":"6.26E-45"},"down","yes","Casp3","protein_coding","chr16:45662910-45684648:-","gi|6978605|ref|NP_037054.1|",1498,0,"caspase-3 [Rattus norvegicus]","gi|672080148|ref|XM_006253130.2|",2421,0,"PREDICTED: Rattus norvegicus caspase 3 (Casp3), transcript variant X1, mRNA","P55213",581,0,"Caspase-3",".",".",".",".","pfam00656","Peptidase_C14","Caspase domain.","GO:0001554|luteolysis;GO:0001666|response to hypoxia;GO:0001782|B cell homeostasis;GO:0006508|proteolysis;GO:0006915|apoptotic process;GO:0006974|cellular response to DNA damage stimulus;GO:0007413|axonal fasciculation;GO:0007507|heart development;GO:0007605|sensory perception of sound;GO:0007611|learning or memory;GO:0008627|intrinsic apoptotic signaling pathway in response to osmotic stress;GO:0009410|response to xenobiotic stimulus;GO:0009411|response to UV;GO:0009611|response to wounding;GO:0009749|response to glucose;GO:0010033|response to organic substance;GO:0010038|response to metal ion;GO:0010165|response to X-ray;GO:0010996|response to auditory stimulus;GO:0014070|response to organic cyclic compound;GO:0016485|protein processing;GO:0021766|hippocampus development;GO:0030182|neuron differentiation;GO:0030216|keratinocyte differentiation;GO:0030218|erythrocyte differentiation;GO:0030889|negative regulation of B cell proliferation;GO:0031647|regulation of protein stability;GO:0032025|response to cobalt ion;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0034349|glial cell apoptotic process;GO:0035094|response to nicotine;GO:0035556|intracellular signal transduction;GO:0042060|wound healing;GO:0042542|response to hydrogen peroxide;GO:0043029|T cell homeostasis;GO:0043065|positive regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0043200|response to amino acid;GO:0043525|positive regulation of neuron apoptotic process;GO:0045165|cell fate commitment;GO:0045736|negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045786|negative regulation of cell cycle;GO:0046007|negative regulation of activated T cell proliferation;GO:0046677|response to antibiotic;GO:0048011|neurotrophin TRK receptor signaling pathway;GO:0051146|striated muscle cell differentiation;GO:0051384|response to glucocorticoid;GO:0051402|neuron apoptotic process;GO:0061713|anterior neural tube closure;GO:0071310|cellular response to organic substance;GO:0071407|cellular response to organic cyclic compound;GO:0071887|leukocyte apoptotic process;GO:0072734|cellular response to staurosporine;GO:0097194|execution phase of apoptosis;GO:1902004|positive regulation of amyloid-beta formation;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0031264|death-inducing signaling complex;GO:0043025|neuronal cell body;GO:0045121|membrane raft;","GO:0002020|protease binding;GO:0004175|endopeptidase activity;GO:0004190|aspartic-type endopeptidase activity;GO:0004197|cysteine-type endopeptidase activity;GO:0004861|cyclin-dependent protein serine/threonine kinase inhibitor activity;GO:0005123|death receptor binding;GO:0005515|protein binding;GO:0008233|peptidase activity;GO:0008234|cysteine-type peptidase activity;GO:0016005|phospholipase A2 activator activity;GO:0044877|protein-containing complex binding;GO:0097153|cysteine-type endopeptidase activity involved in apoptotic process;GO:0097199|cysteine-type endopeptidase activity involved in apoptotic signaling pathway;GO:0097200|cysteine-type endopeptidase activity involved in execution phase of apoptosis;","K02187","CASP3; caspase 3 [EC:3.4.22.56]"]
["ENSRNOG00000008005",217,13.95970509,614,39.64098183,0.352153364,-1.505724232,{"v":3.79896e-45,"d":"3.80E-45"},{"v":1.12595e-44,"d":"1.13E-44"},"down","yes","Akna","protein_coding","chr5:76777415-76816017:-","gi|157822031|ref|NP_001102138.1|",6575,0,"AT-hook-containing transcription factor [Rattus norvegicus]","gi|157822030|ref|NM_001108668.1|",5353,0,"Rattus norvegicus AT-hook transcription factor (Akna), mRNA","Q80VW7",2062,0,"AT-hook-containing transcription factor",".",".",".",".","pfam12443","AKNA","AT-hook-containing transcription factor. This domain family is found in eukaryotes, and is approximately 110 amino acids in length. This family contains a transcription factor which regulates the expression of the costimulatory molecules on lymphocytes.","GO:0001837|epithelial to mesenchymal transition;GO:0021849|neuroblast division in subventricular zone;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050727|regulation of inflammatory response;GO:0060232|delamination;GO:0060234|neuroblast delamination;","GO:0001650|fibrillar center;GO:0005654|nucleoplasm;GO:0005813|centrosome;GO:0005814|centriole;GO:0005829|cytosol;GO:0005874|microtubule;GO:0043231|intracellular membrane-bounded organelle;",".","K21404","AKNA; AT-hook-containing transcription factor"]
["ENSRNOG00000014168",518,33.32316698,1071,69.14575169,0.481926455,-1.053115096,{"v":4.54797E-45,"d":"4.55E-45"},{"v":1.34262E-44,"d":"1.34E-44"},"down","yes","Xylb","protein_coding","chr8:119096029-119128848:+","gi|149018273|gb|EDL76914.1|",2717,0,"xylulokinase homolog (H. influenzae) [Rattus norvegicus]","gi|564366284|ref|XM_006244093.1|",3285,0,"PREDICTED: Rattus norvegicus xylulokinase homolog (H. influenzae) (Xylb), transcript variant X1, mRNA","Q3MIF4",1038,0,"Xylulose kinase","SPCPJ732.02c",297,{"v":2E-87,"d":"2.00E-87"},"COG1070","pfam02782","FGGY_C","FGGY family of carbohydrate kinases, C-terminal domain. This domain adopts a ribonuclease H-like fold and is structurally related to the N-terminal domain.","GO:0005997|xylulose metabolic process;GO:0016310|phosphorylation;GO:0042732|D-xylose metabolic process;GO:0046835|carbohydrate phosphorylation;","GO:0005829|cytosol;","GO:0004856|xylulokinase activity;GO:0005524|ATP binding;GO:0016773|phosphotransferase activity, alcohol group as acceptor;","K00854","xylB, XYLB; xylulokinase [EC:2.7.1.17]"]
["ENSRNOG00000000661",390,25.08887089,884,57.07268394,0.439595077,-1.185752865,{"v":4.83754e-45,"d":"4.84E-45"},{"v":1.42436e-44,"d":"1.42E-44"},"down","yes","Hps4","protein_coding","chr12:44264037-44294632:-","gi|849515601|ref|NP_001100618.2|",2883,0,"Hermansky-Pudlak syndrome 4 protein [Rattus norvegicus]","gi|672073320|ref|XM_006249546.2|",2001,0,"PREDICTED: Rattus norvegicus Hermansky-Pudlak syndrome 4 (Hps4), transcript variant X8, mRNA","Q99KG7",863,0,"Hermansky-Pudlak syndrome 4 protein homolog",".",".",".",".","pfam03154","Atrophin-1","Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.","GO:0006605|protein targeting;GO:0006996|organelle organization;GO:0007040|lysosome organization;GO:0007596|blood coagulation;GO:0008150|biological_process;GO:0016192|vesicle-mediated transport;GO:0030318|melanocyte differentiation;GO:0050790|regulation of catalytic activity;GO:0050821|protein stabilization;GO:1903232|melanosome assembly;GO:1903955|positive regulation of protein targeting to mitochondrion;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0005765|lysosomal membrane;GO:0016020|membrane;GO:0031085|BLOC-3 complex;GO:0031410|cytoplasmic vesicle;GO:0042470|melanosome;GO:0042827|platelet dense granule;","GO:0003674|molecular_function;GO:0005085|guanyl-nucleotide exchange factor activity;GO:0031267|small GTPase binding;GO:0042803|protein homodimerization activity;GO:0046983|protein dimerization activity;","K20194","HPS4; Hermansky-Pudlak syndrome 4 protein"]
["ENSRNOG00000056996",3,0.192991315,183,11.81482032,0.01633468,-5.935917957,{"v":4.83824e-45,"d":"4.84E-45"},{"v":1.42436e-44,"d":"1.42E-44"},"down","yes","Cfap65","protein_coding","chr9:76459211-76494128:-","gi|672065915|ref|XP_008765530.1|",8880,0,"PREDICTED: LOW QUALITY PROTEIN: coiled-coil domain-containing protein 108 isoform X2 [Rattus norvegicus]","gi|672065914|ref|XM_008767308.1|",4292,0,"PREDICTED: Rattus norvegicus coiled-coil domain containing 108 (Ccdc108), transcript variant X2, mRNA","Q3V0B4",3169,0,"Cilia- and flagella-associated protein 65",".",".",".",".","pfam15301","SLAIN","SLAIN motif-containing family. The SLAIN motif containing family is named after the presence of a SLAIN motif in SLAIN1. They are a family of microtubule plus-end tracking proteins.",".",".",".","K24226","CFAP65; cilia- and flagella-associated protein 65"]
["ENSRNOG00000004482",257,16.53292261,677,43.70837899,0.378255222,-1.402568094,{"v":8.85531e-45,"d":"8.86E-45"},{"v":2.60028E-44,"d":"2.60E-44"},"down","yes","Ccdc88c","protein_coding","chr6:120169738-120289555:-","gi|293348214|ref|XP_001065209.2|",9174,0,"PREDICTED: protein Daple [Rattus norvegicus]","gi|672021054|ref|XM_001065209.4|",7637,0,"PREDICTED: Rattus norvegicus coiled-coil domain containing 88C (Ccdc88c), mRNA","Q6VGS5",3227,0,"Protein Daple",".",".",".",".","pfam05622","HOOK","HOOK protein. This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organisms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas the central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head.","GO:0001932|regulation of protein phosphorylation;GO:0003383|apical constriction;GO:0007264|small GTPase mediated signal transduction;GO:0030705|cytoskeleton-dependent intracellular transport;GO:0031098|stress-activated protein kinase signaling cascade;GO:0031122|cytoplasmic microtubule organization;GO:0031648|protein destabilization;GO:0035567|non-canonical Wnt signaling pathway;GO:0050790|regulation of catalytic activity;GO:0090090|negative regulation of canonical Wnt signaling pathway;","GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0030054|cell junction;","GO:0001965|G-protein alpha-subunit binding;GO:0005085|guanyl-nucleotide exchange factor activity;GO:0005109|frizzled binding;GO:0008017|microtubule binding;GO:0030165|PDZ domain binding;GO:0042802|identical protein binding;GO:0043621|protein self-association;GO:0051959|dynein light intermediate chain binding;",".","."]
["ENSRNOG00000027380",82,5.275095931,368,23.75876435,0.222027369,-2.171190571,{"v":1.08434e-44,"d":"1.08E-44"},{"v":3.1808e-44,"d":"3.18E-44"},"down","yes","Upk1b","protein_coding","chr11:61953648-61991029:+","gi|564376894|ref|XP_006248429.1|",1479,0,"PREDICTED: uroplakin-1b isoform X2 [Rattus norvegicus]","gi|672071154|ref|XM_006248367.2|",1980,0,"PREDICTED: Rattus norvegicus uroplakin 1B (Upk1b), transcript variant X1, mRNA","Q566D0",545,0,"Uroplakin-1b",".",".",".",".","pfam00335","Tetraspannin","Tetraspanin family.","GO:0009617|response to bacterium;GO:0030855|epithelial cell differentiation;","GO:0005887|integral component of plasma membrane;GO:0016324|apical plasma membrane;GO:0120001|apical plasma membrane urothelial plaque;",".","K17347","UPK1; uroplakin-1"]
["ENSRNOG00000007329",497,31.97222778,1038,67.01521032,0.477089121,-1.067669306,{"v":1.09953E-44,"d":"1.10E-44"},{"v":3.22368e-44,"d":"3.22E-44"},"down","yes","Frmd6","protein_coding","chr6:89346035-89419579:+","gi|148704624|gb|EDL36571.1|",2887,0,"FERM domain containing 6, isoform CRA_b, partial [Mus musculus]","gi|672056262|ref|XM_006240152.2|",4594,0,"PREDICTED: Rattus norvegicus FERM domain containing 6 (Frmd6), transcript variant X2, mRNA","Q8C0V9",1046,0,"FERM domain-containing protein 6",".",".",".",".","pfam09380","FERM_C","FERM C-terminal PH-like domain.","GO:0003383|apical constriction;GO:0031032|actomyosin structure organization;GO:0032970|regulation of actin filament-based process;GO:0034613|cellular protein localization;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0043296|apical junction complex;",".","K16822","FRMD6; FERM domain-containing protein 6"]
["ENSRNOG00000014797",478,30.74994945,1010,65.20747825,0.471570904,-1.084453389,{"v":1.33535e-44,"d":"1.34E-44"},{"v":3.91309e-44,"d":"3.91E-44"},"down","yes","Tmbim1","protein_coding","chr9:75871835-75889069:-","gi|672065607|ref|XP_008765461.1|",1118,{"v":5e-145,"d":"5.00E-145"},"PREDICTED: protein lifeguard 3 isoform X2 [Rattus norvegicus]","gi|672065606|ref|XM_008767239.1|",2091,0,"PREDICTED: Rattus norvegicus transmembrane BAX inhibitor motif containing 1 (Tmbim1), transcript variant X2, mRNA","Q8BJZ3",382,{"v":5e-125,"d":"5.00E-125"},"Protein lifeguard 3","SPCC576.04",69.7,{"v":3e-12,"d":"3.00E-12"},"COG0670","pfam01027","Bax1-I","Inhibitor of apoptosis-promoting Bax1. Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner.","GO:0043086|negative regulation of catalytic activity;GO:1902042|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1902045|negative regulation of Fas signaling pathway;GO:1903077|negative regulation of protein localization to plasma membrane;GO:2000504|positive regulation of blood vessel remodeling;","GO:0005765|lysosomal membrane;GO:0005794|Golgi apparatus;GO:0010008|endosome membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0005123|death receptor binding;","K24205","TMBIM, LFG; protein lifeguard"]
["ENSRNOG00000001103",95,6.111391628,393,25.37281084,0.2408638,-2.053710513,{"v":1.7428e-44,"d":"1.74E-44"},{"v":5.09921e-44,"d":"5.10E-44"},"down","yes","Sdk1","protein_coding","chr12:12380524-13363976:-","gi|164518930|ref|NP_808547.3|",10684,0,"protein sidekick-1 [Mus musculus]","gi|672026520|ref|XM_008758963.1|",6779,0,"PREDICTED: Rattus norvegicus sidekick cell adhesion molecule 1 (Sdk1), transcript variant X1, mRNA","Q3UH53",4113,0,"Protein sidekick-1",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0048148|behavioral response to cocaine;GO:0060998|regulation of dendritic spine development;",".",".","K16353","SDK; protein sidekick"]
["ENSRNOG00000021100",225,14.47434859,623,40.22203857,0.359861139,-1.474487781,{"v":1.9578E-44,"d":"1.96E-44"},{"v":5.72535e-44,"d":"5.73E-44"},"down","yes","Tnfaip8l2","protein_coding","chr2:182709378-182726760:-","gi|62078809|ref|NP_001014061.1|",870,{"v":1e-105,"d":"1.00E-105"},"tumor necrosis factor alpha-induced protein 8-like protein 2 [Rattus norvegicus]","gi|672043420|ref|XM_008761303.1|",2137,0,"PREDICTED: Rattus norvegicus tumor necrosis factor, alpha-induced protein 8-like 2 (Tnfaip8l2), transcript variant X1, mRNA","Q6AYJ8",339,{"v":4E-107,"d":"4.00E-107"},"Tumor necrosis factor alpha-induced protein 8-like protein 2",".",".",".",".","pfam05527","DUF758","Domain of unknown function (DUF758). Family of eukaryotic proteins with unknown function, which are induced by tumor necrosis factor.","GO:0042981|regulation of apoptotic process;GO:0045087|innate immune response;GO:0050728|negative regulation of inflammatory response;GO:0050868|negative regulation of T cell activation;","GO:0005737|cytoplasm;",".",".","."]
["ENSRNOG00000017395",43,2.766208842,282,18.20644442,0.151935698,-2.718467217,{"v":2.0108E-44,"d":"2.01E-44"},{"v":5.87732e-44,"d":"5.88E-44"},"down","yes","Duox2","protein_coding","chr3:109226924-109245902:-","gi|564342615|ref|XP_006234924.1|",8437,0,"PREDICTED: dual oxidase 2 isoform X1 [Rattus norvegicus]","gi|672046991|ref|XM_006234862.2|",6234,0,"PREDICTED: Rattus norvegicus dual oxidase 2 (Duox2), transcript variant X1, mRNA","Q9ES45",3041,0,"Dual oxidase 2",".",".",".",".","pfam03098","An_peroxidase","Animal haem peroxidase.","GO:0006590|thyroid hormone generation;GO:0006952|defense response;GO:0006979|response to oxidative stress;GO:0009566|fertilization;GO:0009615|response to virus;GO:0019221|cytokine-mediated signaling pathway;GO:0030282|bone mineralization;GO:0030878|thyroid gland development;GO:0035264|multicellular organism growth;GO:0042335|cuticle development;GO:0042403|thyroid hormone metabolic process;GO:0042445|hormone metabolic process;GO:0042446|hormone biosynthetic process;GO:0042554|superoxide anion generation;GO:0042744|hydrogen peroxide catabolic process;GO:0048839|inner ear development;GO:0048855|adenohypophysis morphogenesis;GO:0050665|hydrogen peroxide biosynthetic process;GO:0051591|response to cAMP;GO:0090303|positive regulation of wound healing;GO:0098869|cellular oxidant detoxification;GO:2000147|positive regulation of cell motility;","GO:0005575|cellular_component;GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0030054|cell junction;GO:0031252|cell leading edge;GO:0043020|NADPH oxidase complex;GO:0045177|apical part of cell;","GO:0004601|peroxidase activity;GO:0005509|calcium ion binding;GO:0016174|NAD(P)H oxidase activity;GO:0016175|superoxide-generating NADPH oxidase activity;GO:0020037|heme binding;","K13411","DUOX, THOX; dual oxidase [EC:1.6.3.1 1.11.1.-]"]
["ENSRNOG00000007484",8,0.514643505,189,12.20219147,0.042176318,-4.567423044,{"v":2.75274e-44,"d":"2.75E-44"},{"v":8.0254e-44,"d":"8.03E-44"},"down","yes","Ehf","protein_coding","chr3:89641833-89679997:-","gi|157817348|ref|NP_001099963.1|",1631,0,"ETS homologous factor [Rattus norvegicus]","gi|187937127|ref|NM_001106493.2|",2337,0,"Rattus norvegicus ets homologous factor (Ehf), mRNA","O70273",624,0,"ETS homologous factor",".",".",".",".","pfam00178","Ets","Ets-domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0006366|transcription by RNA polymerase II;GO:0030154|cell differentiation;GO:0030855|epithelial cell differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050673|epithelial cell proliferation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005794|Golgi apparatus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;","K17102","EHF; ETS homologous factor"]
["ENSRNOG00000010085",14,0.900626135,206,13.29974309,0.067717559,-3.884326224,{"v":3.07341e-44,"d":"3.07E-44"},{"v":8.9557e-44,"d":"8.96E-44"},"down","yes","Cldn10","protein_coding","chr15:95862760-95954526:+","gi|157821473|ref|NP_001099528.1|",1492,0,"claudin-10 [Rattus norvegicus]","gi|157821472|ref|NM_001106058.1|",1331,0,"Rattus norvegicus claudin 10 (Cldn10), mRNA","Q9Z0S6",462,{"v":2e-161,"d":"2.00E-161"},"Claudin-10",".",".",".",".","pfam00822","PMP22_Claudin","PMP-22/EMP/MP20/Claudin family.","GO:0007155|cell adhesion;GO:0043269|regulation of ion transport;GO:0070830|bicellular tight junction assembly;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005923|bicellular tight junction;GO:0016021|integral component of membrane;","GO:0005198|structural molecule activity;","K06087","CLDN; claudin"]
["ENSRNOG00000005806",4,0.257321753,179,11.55657288,0.022266268,-5.488996397,{"v":5.02403e-44,"d":"5.02E-44"},{"v":1.45802e-43,"d":"1.46E-43"},"down","yes","Oxtr","protein_coding","chr4:145599561-145614674:-","gi|9845279|ref|NP_037003.2|",1779,0,"oxytocin receptor [Rattus norvegicus]","gi|672050647|ref|XM_008763182.1|",3563,0,"PREDICTED: Rattus norvegicus oxytocin receptor (Oxtr), transcript variant X5, mRNA","P70536",689,0,"Oxytocin receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001967|suckling behavior;GO:0001975|response to amphetamine;GO:0001992|regulation of systemic arterial blood pressure by vasopressin;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007507|heart development;GO:0007565|female pregnancy;GO:0007613|memory;GO:0009410|response to xenobiotic stimulus;GO:0010701|positive regulation of norepinephrine secretion;GO:0014070|response to organic cyclic compound;GO:0021537|telencephalon development;GO:0030431|sleep;GO:0032230|positive regulation of synaptic transmission, GABAergic;GO:0032355|response to estradiol;GO:0032570|response to progesterone;GO:0034059|response to anoxia;GO:0034097|response to cytokine;GO:0035176|social behavior;GO:0042220|response to cocaine;GO:0042711|maternal behavior;GO:0042713|sperm ejaculation;GO:0042755|eating behavior;GO:0043434|response to peptide hormone;GO:0044058|regulation of digestive system process;GO:0044849|estrous cycle;GO:0045777|positive regulation of blood pressure;GO:0045907|positive regulation of vasoconstriction;GO:0048545|response to steroid hormone;GO:0048565|digestive tract development;GO:0051965|positive regulation of synapse assembly;GO:0051968|positive regulation of synaptic transmission, glutamatergic;GO:0060137|maternal process involved in parturition;GO:0060406|positive regulation of penile erection;GO:0060455|negative regulation of gastric acid secretion;GO:0070371|ERK1 and ERK2 cascade;GO:0070474|positive regulation of uterine smooth muscle contraction;GO:0120162|positive regulation of cold-induced thermogenesis;","GO:0005887|integral component of plasma membrane;GO:0005902|microvillus;GO:0005912|adherens junction;GO:0016324|apical plasma membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004990|oxytocin receptor activity;GO:0005000|vasopressin receptor activity;GO:0005515|protein binding;GO:0017046|peptide hormone binding;GO:0042277|peptide binding;","K04229","OXTR; oxytocin receptor"]
["ENSRNOG00000058156",557,35.83205407,1118,72.18015909,0.496425258,-1.010351575,{"v":5.40652e-44,"d":"5.41E-44"},{"v":1.56822e-43,"d":"1.57E-43"},"down","yes","Zdhhc18","protein_coding","chr5:145831446-145859993:-","gi|86129586|ref|NP_001034428.1|",1366,{"v":3e-170,"d":"3.00E-170"},"palmitoyltransferase ZDHHC18 [Rattus norvegicus]","gi|86129585|ref|NM_001039339.1|",1728,0,"Rattus norvegicus zinc finger, DHHC-type containing 18 (Zdhhc18), mRNA","Q2TGJ1",530,{"v":1e-171,"d":"1.00E-171"},"Palmitoyltransferase ZDHHC18","SPBC3H7.09",115,{"v":5e-26,"d":"5.00E-26"},"COG5273","pfam01529","zf-DHHC","DHHC palmitoyltransferase. This family includes the well known DHHC zinc binding domain as well as three of the four conserved transmembrane regions found in this family of palmitoyltransferase enzymes.","GO:0006612|protein targeting to membrane;GO:0018230|peptidyl-L-cysteine S-palmitoylation;GO:0018345|protein palmitoylation;GO:0034613|cellular protein localization;","GO:0000139|Golgi membrane;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;","GO:0016409|palmitoyltransferase activity;GO:0019706|protein-cysteine S-palmitoyltransferase activity;","K16675","ZDHHC9_14_18; palmitoyltransferase ZDHHC9/14/18 [EC:2.3.1.225]"]
["ENSRNOG00000021041",220,14.1526964,612,39.51185811,0.358188581,-1.481208749,{"v":5.76372e-44,"d":"5.76E-44"},{"v":1.67014E-43,"d":"1.67E-43"},"down","yes","Fam171a2","protein_coding","chr10:87394007-87404053:-","gi|392351637|ref|XP_002727867.2|",3164,0,"PREDICTED: protein FAM171A2 isoform X2 [Rattus norvegicus]","gi|672069360|ref|XM_002727821.4|",2988,0,"PREDICTED: Rattus norvegicus family with sequence similarity 171, member A2 (Fam171a2), transcript variant X2, mRNA","A2A699",1202,0,"Protein FAM171A2",".",".",".",".","pfam10577","UPF0560","Uncharacterized protein family UPF0560. This family of proteins has no known function.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000023969",169,10.87184405,525,33.89497632,0.320750897,-1.640474796,{"v":8.73051e-44,"d":"8.73E-44"},{"v":2.52086e-43,"d":"2.52E-43"},"down","yes","Herc6","protein_coding","chr4:87524493-87581744:-","gi|55249804|gb|AAH85921.1|",5197,0,"Herc6 protein, partial [Rattus norvegicus]","gi|672049854|ref|XM_008762963.1|",4089,0,"PREDICTED: Rattus norvegicus HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 (Herc6), transcript variant X2, mRNA","F2Z461",1543,0,"E3 ISG15--protein ligase Herc6","SPBP8B7.27",154,{"v":5e-37,"d":"5.00E-37"},"COG5021","pfam00632","HECT","HECT-domain (ubiquitin-transferase). The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.","GO:0002244|hematopoietic progenitor cell differentiation;GO:0009617|response to bacterium;GO:0016567|protein ubiquitination;","GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0004842|ubiquitin-protein transferase activity;","K22372","HERC5_6; E3 ISG15--protein ligase [EC:2.3.2.-]"]
["ENSRNOG00000006450",129,8.298626526,453,29.24652242,0.283747463,-1.817320604,{"v":1.29035E-43,"d":"1.29E-43"},{"v":3.72013e-43,"d":"3.72E-43"},"down","yes","Erbb2","protein_coding","chr10:83411313-83435078:+","gi|77020289|ref|NP_058699.2|",6011,0,"receptor tyrosine-protein kinase erbB-2 precursor [Rattus norvegicus]","gi|77020288|ref|NM_017003.2|",4719,0,"Rattus norvegicus erb-b2 receptor tyrosine kinase 2 (Erbb2), mRNA","P06494",2303,0,"Receptor tyrosine-protein kinase erbB-2",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001889|liver development;GO:0001934|positive regulation of protein phosphorylation;GO:0007165|signal transduction;GO:0007166|cell surface receptor signaling pathway;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007275|multicellular organism development;GO:0007399|nervous system development;GO:0007417|central nervous system development;GO:0007422|peripheral nervous system development;GO:0007507|heart development;GO:0007519|skeletal muscle tissue development;GO:0007528|neuromuscular junction development;GO:0008045|motor neuron axon guidance;GO:0008284|positive regulation of cell proliferation;GO:0009410|response to xenobiotic stimulus;GO:0010001|glial cell differentiation;GO:0010628|positive regulation of gene expression;GO:0014065|phosphatidylinositol 3-kinase signaling;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0030182|neuron differentiation;GO:0030307|positive regulation of cell growth;GO:0032570|response to progesterone;GO:0032886|regulation of microtubule-based process;GO:0033088|negative regulation of immature T cell proliferation in thymus;GO:0033674|positive regulation of kinase activity;GO:0035556|intracellular signal transduction;GO:0042060|wound healing;GO:0042127|regulation of cell proliferation;GO:0042552|myelination;GO:0043066|negative regulation of apoptotic process;GO:0043406|positive regulation of MAP kinase activity;GO:0043410|positive regulation of MAPK cascade;GO:0043547|positive regulation of GTPase activity;GO:0043586|tongue development;GO:0044849|estrous cycle;GO:0045595|regulation of cell differentiation;GO:0045727|positive regulation of translation;GO:0045785|positive regulation of cell adhesion;GO:0045943|positive regulation of transcription by RNA polymerase I;GO:0046579|positive regulation of Ras protein signal transduction;GO:0046777|protein autophosphorylation;GO:0048485|sympathetic nervous system development;GO:0048678|response to axon injury;GO:0048709|oligodendrocyte differentiation;GO:0050679|positive regulation of epithelial cell proliferation;GO:0060056|mammary gland involution;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:0071363|cellular response to growth factor stimulus;GO:0071364|cellular response to epidermal growth factor stimulus;GO:0090314|positive regulation of protein targeting to membrane;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005769|early endosome;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005902|microvillus;GO:0009925|basal plasma membrane;GO:0010008|endosome membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0031410|cytoplasmic vesicle;GO:0038143|ERBB3:ERBB2 complex;GO:0042995|cell projection;GO:0043209|myelin sheath;GO:0043219|lateral loop;GO:0043235|receptor complex;GO:0045121|membrane raft;GO:0045211|postsynaptic membrane;GO:0048471|perinuclear region of cytoplasm;","GO:0001042|RNA polymerase I core binding;GO:0003677|DNA binding;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004888|transmembrane signaling receptor activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0008022|protein C-terminus binding;GO:0019838|growth factor binding;GO:0019903|protein phosphatase binding;GO:0031625|ubiquitin protein ligase binding;GO:0042802|identical protein binding;GO:0043125|ErbB-3 class receptor binding;GO:0044877|protein-containing complex binding;GO:0046982|protein heterodimerization activity;GO:0051879|Hsp90 protein binding;","K05083","ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]"]
["ENSRNOG00000004807",378,24.31690563,856,55.26495186,0.440005914,-1.184405182,{"v":1.35326e-43,"d":"1.35E-43"},{"v":3.89757e-43,"d":"3.90E-43"},"down","yes","Arf2","protein_coding","chr10:88867836-88889659:+","gi|589914549|ref|XP_006970612.1|",980,{"v":1e-124,"d":"1.00E-124"},"PREDICTED: ADP-ribosylation factor 2-like isoform X1 [Peromyscus maniculatus bairdii]","gi|672069555|ref|XM_006247543.2|",1628,0,"PREDICTED: Rattus norvegicus ADP-ribosylation factor 2 (Arf2), transcript variant X1, mRNA","P84082",374,{"v":4e-123,"d":"4.00E-123"},"ADP-ribosylation factor 2",".",".",".",".","pfam00025","Arf","ADP-ribosylation factor family. Pfam combines a number of different Prosite families together","GO:0006886|intracellular protein transport;GO:0016192|vesicle-mediated transport;","GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;","GO:0003924|GTPase activity;GO:0005525|GTP binding;","K07937","ARF1_2; ADP-ribosylation factor 1/2"]
["ENSRNOG00000028801",298,19.17047058,734,47.38840499,0.404539266,-1.305648352,{"v":1.47145E-43,"d":"1.47E-43"},{"v":4.23583e-43,"d":"4.24E-43"},"down","yes","Gsap","protein_coding","chr4:13813046-13907814:-","gi|564345361|ref|XP_006235997.1|",4246,0,"PREDICTED: gamma-secretase-activating protein isoform X1 [Rattus norvegicus]","gi|672048632|ref|XM_008762649.1|",1943,0,"PREDICTED: Rattus norvegicus gamma-secretase activating protein (Gsap), transcript variant X4, mRNA","Q3TCV3",1456,0,"Gamma-secretase-activating protein",".",".",".",".","pfam14959","GSAP-16","gamma-Secretase-activating protein C-term. GSAP, or gamma-secretase-activating protein, also known as PION, regulates gamma-secretase activity. The holo-protein is a large, approx 850 residue protein that is rapidly cleaved to an active 16 kDa C-terminal fragment that is the stable, predominant form. GSAP is expressed in inclusion bodies and is important in brain function. It dramatically and selectively increases neurotoxic beta-Amyloid production in the brain through a mechanism involving its interactions with both gamma-secretase and its substrate, the amyloid precursor protein C-terminal fragment (APP-CTF). Accumulation of neurotoxic beta-Amyloid is a major hallmark of Alzheimer's disease. Formation of beta-Amyloid is catalysed by gamma-secretase, a protease with numerous substrates that catalyses the intra-membrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). The secondary structure of GSAP is largely alpha-helical, lacking well-defined tertiary structure. GSAP represents a type of gamma-secretase regulator that directs enzyme specificity by interacting with a specific substrate.","GO:0030162|regulation of proteolysis;GO:1902004|positive regulation of amyloid-beta formation;","GO:0005802|trans-Golgi network;","GO:0001540|amyloid-beta binding;",".","."]
["ENSRNOG00000038686",467,30.04231463,986,63.65799362,0.471933106,-1.083345716,{"v":1.63352e-43,"d":"1.63E-43"},{"v":4.69764e-43,"d":"4.70E-43"},"down","yes","ENSRNOG00000038686","protein_coding","chrX:30572751-30597262:-","gi|672087336|ref|XP_008771389.1|",837,{"v":4e-101,"d":"4.00E-101"},"PREDICTED: AP-1 complex subunit sigma-2 isoform X1 [Rattus norvegicus]","gi|672087335|ref|XM_008773167.1|",2353,0,"PREDICTED: Rattus norvegicus adaptor-related protein complex 1, sigma 2 subunit (Ap1s2), transcript variant X1, mRNA","P56377",291,{"v":9e-90,"d":"9.00E-90"},"AP-1 complex subunit sigma-2","SPAP27G11.06c",187,{"v":3e-53,"d":"3.00E-53"},"COG5030","pfam01217","Clat_adaptor_s","Clathrin adaptor complex small chain.","GO:0006886|intracellular protein transport;GO:0008150|biological_process;GO:0008542|visual learning;GO:0016182|synaptic vesicle budding from endosome;GO:0016192|vesicle-mediated transport;GO:0036465|synaptic vesicle recycling;GO:0045444|fat cell differentiation;GO:0050885|neuromuscular process controlling balance;GO:0060612|adipose tissue development;","GO:0005575|cellular_component;GO:0005794|Golgi apparatus;GO:0030121|AP-1 adaptor complex;GO:0043231|intracellular membrane-bounded organelle;GO:0098793|presynapse;","GO:0003674|molecular_function;GO:0035615|clathrin adaptor activity;","K12394","AP1S1_2; AP-1 complex subunit sigma 1/2"]
["ENSRNOG00000024703",500,32.16521909,1033,66.69240102,0.482292114,-1.052020874,{"v":1.8433e-43,"d":"1.84E-43"},{"v":5.29827e-43,"d":"5.30E-43"},"down","yes","Dock5","protein_coding","chr15:41979729-42158649:-","gi|392333354|ref|XP_003752870.1|",9595,0,"PREDICTED: dedicator of cytokinesis protein 5 isoform X1 [Rattus norvegicus]","gi|672028663|ref|XM_003752822.3|",10185,0,"PREDICTED: Rattus norvegicus dedicator of cytokinesis 5 (Dock5), transcript variant X1, mRNA","B2RY04",3631,0,"Dedicator of cytokinesis protein 5",".",".",".",".","pfam14429","DOCK-C2","C2 domain in Dock180 and Zizimin proteins. The Dock180/Dock1 and Zizimin proteins are atypical GTP/GDP exchange factors for the small GTPases Rac and Cdc42 and are implicated cell-migration and phagocytosis. Across all Dock180 proteins, two regions are conserved: C-terminus termed CZH2 or DHR2 (or the Dedicator of cytokinesis) whereas CZH1/DHR1 contain a new family of the C2 domain.","GO:0007264|small GTPase mediated signal transduction;GO:0010634|positive regulation of epithelial cell migration;GO:0016477|cell migration;GO:0050790|regulation of catalytic activity;GO:1900026|positive regulation of substrate adhesion-dependent cell spreading;GO:1904694|negative regulation of vascular smooth muscle contraction;GO:1904754|positive regulation of vascular associated smooth muscle cell migration;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0005085|guanyl-nucleotide exchange factor activity;","K17707","DOCK5; dedicator of cytokinesis protein 5"]
["ENSRNOG00000001187",82,5.275095931,362,23.3713932,0.22570738,-2.147474502,{"v":2.05047E-43,"d":"2.05E-43"},{"v":5.88486e-43,"d":"5.88E-43"},"down","yes","Oasl","protein_coding","chr12:41682900-41695641:-","gi|403399503|sp|G3V645.1|OASL1_RAT",2628,0,"RecName: Full=2'-5'-oligoadenylate synthase-like protein 1","gi|57527343|ref|NM_001009681.1|",1977,0,"Rattus norvegicus 2'-5'-oligoadenylate synthetase-like (Oasl), mRNA","G3V645",1016,0,"2'-5'-oligoadenylate synthase-like protein 1",".",".",".",".","pfam10421","OAS1_C","2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus. This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between 320 and 344 at the extreme C-terminal end. Oligoadenylate synthetases are antiviral enzymes that counteract vial attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesize 2'.5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication. This domain is often associated with NTP_transf_2 pfam01909.","GO:0009615|response to virus;GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0051607|defense response to virus;GO:0060700|regulation of ribonuclease activity;GO:0070106|interleukin-27-mediated signaling pathway;GO:1900246|positive regulation of RIG-I signaling pathway;","GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016020|membrane;","GO:0003677|DNA binding;GO:0003725|double-stranded RNA binding;","K14608","OASL; 2'-5'-oligoadenylate synthase-like protein"]
["ENSRNOG00000012499",482,31.00727121,1005,64.88466895,0.477882861,-1.065271069,{"v":3.61595e-43,"d":"3.62E-43"},{"v":1.03674e-42,"d":"1.04E-42"},"down","yes","Rarg","protein_coding","chr7:133367833-133390177:-","gi|207028980|ref|NP_001128721.1|",2061,0,"retinoic acid receptor gamma isoform 1 [Rattus norvegicus]","gi|672060285|ref|XM_008765786.1|",2457,0,"PREDICTED: Rattus norvegicus retinoic acid receptor, gamma (Rarg), transcript variant X3, mRNA","P18911",788,0,"Retinoic acid receptor gamma",".",".",".",".","pfam00105","zf-C4","Zinc finger, C4 type (two domains). In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001843|neural tube closure;GO:0002063|chondrocyte development;GO:0002068|glandular epithelial cell development;GO:0003406|retinal pigment epithelium development;GO:0003417|growth plate cartilage development;GO:0003430|growth plate cartilage chondrocyte growth;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0009755|hormone-mediated signaling pathway;GO:0009952|anterior/posterior pattern specification;GO:0010468|regulation of gene expression;GO:0010628|positive regulation of gene expression;GO:0030154|cell differentiation;GO:0031076|embryonic camera-type eye development;GO:0031641|regulation of myelination;GO:0032331|negative regulation of chondrocyte differentiation;GO:0032526|response to retinoic acid;GO:0035116|embryonic hindlimb morphogenesis;GO:0035264|multicellular organism growth;GO:0043010|camera-type eye development;GO:0043065|positive regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0043068|positive regulation of programmed cell death;GO:0045596|negative regulation of cell differentiation;GO:0045637|regulation of myeloid cell differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048048|embryonic eye morphogenesis;GO:0048384|retinoic acid receptor signaling pathway;GO:0048608|reproductive structure development;GO:0048732|gland development;GO:0060041|retina development in camera-type eye;GO:0060173|limb development;GO:0060324|face development;GO:0060348|bone development;GO:0060349|bone morphogenesis;GO:0060429|epithelium development;GO:0060534|trachea cartilage development;GO:0060740|prostate gland epithelium morphogenesis;GO:0061037|negative regulation of cartilage development;GO:0070384|Harderian gland development;GO:0071300|cellular response to retinoic acid;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003700|DNA-binding transcription factor activity;GO:0004879|nuclear receptor activity;GO:0008270|zinc ion binding;GO:0046965|retinoid X receptor binding;GO:1990837|sequence-specific double-stranded DNA binding;","K08529","RARG, NR1B3; retinoic acid receptor gamma"]
["ENSRNOG00000061403",181,11.64380931,542,34.99252793,0.332751304,-1.587483774,{"v":3.84519e-43,"d":"3.85E-43"},{"v":1.10191e-42,"d":"1.10E-42"},"down","yes","AABR07039446.2","protein_coding","chrX:71220367-71242376:+","gi|564322995|ref|XP_006227480.1|",4726,0,"PREDICTED: toll-like receptor 13 [Rattus norvegicus]","gi|672032506|ref|XM_006227419.2|",3814,0,"PREDICTED: Rattus norvegicus toll-like receptor 13 (Tlr13), transcript variant X2, mRNA","Q6R5N8",1672,0,"Toll-like receptor 13","SPBC19C7.03_1",61.2,2E-8,"COG4886","pfam01582","TIR","TIR domain. The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.",".",".",".",".","."]
["ENSRNOG00000032240",53,3.409513224,299,19.30399604,0.176622147,-2.501261839,{"v":4.75718E-43,"d":"4.76E-43"},{"v":1.36053E-42,"d":"1.36E-42"},"down","yes","Gbp5","protein_coding","chr2:231237748-231257061:+","gi|166091462|ref|NP_001102039.2|",2598,0,"guanylate-binding protein 5 [Rattus norvegicus]","gi|214010143|ref|NM_001108569.3|",2759,0,"Rattus norvegicus guanylate binding protein 5 (Gbp5), mRNA","Q8CFB4",828,0,"Guanylate-binding protein 5",".",".",".",".","pfam02263","GBP","Guanylate-binding protein, N-terminal domain. Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.","GO:0009617|response to bacterium;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032741|positive regulation of interleukin-18 production;GO:0034067|protein localization to Golgi apparatus;GO:0045089|positive regulation of innate immune response;GO:0051289|protein homotetramerization;GO:0071346|cellular response to interferon-gamma;GO:1900017|positive regulation of cytokine production involved in inflammatory response;GO:1900227|positive regulation of NLRP3 inflammasome complex assembly;","GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0031410|cytoplasmic vesicle;GO:0048471|perinuclear region of cytoplasm;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;","K20898","GBP5; guanylate-binding protein 5"]
["ENSRNOG00000019491",112,7.205009077,418,26.98685734,0.266982146,-1.905184829,{"v":6.20877e-43,"d":"6.21E-43"},{"v":1.77212e-42,"d":"1.77E-42"},"down","yes","Stard10","protein_coding","chr1:155718389-155747094:+","gi|564330021|ref|XP_006229912.1|",1571,0,"PREDICTED: PCTP-like protein isoform X2 [Rattus norvegicus]","gi|672037743|ref|XM_006229850.2|",1257,0,"PREDICTED: Rattus norvegicus StAR-related lipid transfer (START) domain containing 10 (Stard10), transcript variant X1, mRNA","Q9JMD3",533,0,"START domain-containing protein 10",".",".",".",".","pfam01852","START","START domain.","GO:0032782|bile acid secretion;GO:0035360|positive regulation of peroxisome proliferator activated receptor signaling pathway;","GO:0005829|cytosol;GO:0005902|microvillus;GO:0016020|membrane;GO:0046581|intercellular canaliculus;","GO:0008289|lipid binding;","K24142","STARD10; StAR-related lipid transfer protein 10"]
["ENSRNOG00000019496",262,16.8545748,673,43.45013155,0.387906186,-1.366220312,{"v":7.49979e-43,"d":"7.50E-43"},{"v":2.13741e-42,"d":"2.14E-42"},"down","yes","Stat5a","protein_coding","chr10:85785537-85809866:+","gi|149054250|gb|EDM06067.1|",4168,0,"rCG35111 [Rattus norvegicus]","gi|8394372|ref|NM_017064.1|",3549,0,"Rattus norvegicus signal transducer and activator of transcription 5A (Stat5a), mRNA","Q62771",1597,0,"Signal transducer and activator of transcription 5A",".",".",".",".","pfam02864","STAT_bind","STAT protein, DNA binding domain. STAT proteins (Signal Transducers and Activators of Transcription) are a family of transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors. This family represents the DNA binding domain of STAT, which has an ig-like fold. STAT proteins also include an SH2 domain pfam00017.","GO:0001553|luteinization;GO:0001779|natural killer cell differentiation;GO:0001938|positive regulation of endothelial cell proliferation;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006366|transcription by RNA polymerase II;GO:0006952|defense response;GO:0007259|JAK-STAT cascade;GO:0007565|female pregnancy;GO:0007595|lactation;GO:0008284|positive regulation of cell proliferation;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0019218|regulation of steroid metabolic process;GO:0019221|cytokine-mediated signaling pathway;GO:0019530|taurine metabolic process;GO:0019915|lipid storage;GO:0030155|regulation of cell adhesion;GO:0030856|regulation of epithelial cell differentiation;GO:0030879|mammary gland development;GO:0031667|response to nutrient levels;GO:0032743|positive regulation of interleukin-2 production;GO:0032825|positive regulation of natural killer cell differentiation;GO:0033026|negative regulation of mast cell apoptotic process;GO:0033077|T cell differentiation in thymus;GO:0038026|reelin-mediated signaling pathway;GO:0040014|regulation of multicellular organism growth;GO:0040018|positive regulation of multicellular organism growth;GO:0042104|positive regulation of activated T cell proliferation;GO:0042127|regulation of cell proliferation;GO:0043029|T cell homeostasis;GO:0043066|negative regulation of apoptotic process;GO:0043434|response to peptide hormone;GO:0043536|positive regulation of blood vessel endothelial cell migration;GO:0045471|response to ethanol;GO:0045579|positive regulation of B cell differentiation;GO:0045588|positive regulation of gamma-delta T cell differentiation;GO:0045621|positive regulation of lymphocyte differentiation;GO:0045647|negative regulation of erythrocyte differentiation;GO:0045931|positive regulation of mitotic cell cycle;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;GO:0046543|development of secondary female sexual characteristics;GO:0046544|development of secondary male sexual characteristics;GO:0048541|Peyer's patch development;GO:0048609|multicellular organismal reproductive process;GO:0050729|positive regulation of inflammatory response;GO:0060056|mammary gland involution;GO:0060376|positive regulation of mast cell differentiation;GO:0060397|JAK-STAT cascade involved in growth hormone signaling pathway;GO:0060740|prostate gland epithelium morphogenesis;GO:0060742|epithelial cell differentiation involved in prostate gland development;GO:0061180|mammary gland epithelium development;GO:0070668|positive regulation of mast cell proliferation;GO:0071345|cellular response to cytokine stimulus;GO:0071407|cellular response to organic cyclic compound;GO:0097011|cellular response to granulocyte macrophage colony-stimulating factor stimulus;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003690|double-stranded DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0005515|protein binding;GO:0042301|phosphate ion binding;GO:0043565|sequence-specific DNA binding;","K11223","STAT5A; signal transducer and activator of transcription 5A"]
["ENSRNOG00000051986",49,3.152191471,289,18.65837744,0.168942422,-2.565396458,{"v":8.0977e-43,"d":"8.10E-43"},{"v":2.30321e-42,"d":"2.30E-42"},"down","yes","Plcg2","protein_coding","chr19:45547416-45683930:+","gi|148679636|gb|EDL11583.1|",6979,0,"phospholipase C, gamma 2 [Mus musculus]","gi|8393983|ref|NM_017168.1|",4282,0,"Rattus norvegicus phospholipase C, gamma 2 (Plcg2), mRNA","P24135",2620,0,"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2",".",".",".",".","pfam00388","PI-PLC-X","Phosphatidylinositol-specific phospholipase C, X domain. This associates with pfam00387 to form a single structural unit.","GO:0001775|cell activation;GO:0001878|response to yeast;GO:0002092|positive regulation of receptor internalization;GO:0002223|stimulatory C-type lectin receptor signaling pathway;GO:0002224|toll-like receptor signaling pathway;GO:0002281|macrophage activation involved in immune response;GO:0002316|follicular B cell differentiation;GO:0002732|positive regulation of dendritic cell cytokine production;GO:0006661|phosphatidylinositol biosynthetic process;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0009395|phospholipid catabolic process;GO:0010468|regulation of gene expression;GO:0010628|positive regulation of gene expression;GO:0010634|positive regulation of epithelial cell migration;GO:0019216|regulation of lipid metabolic process;GO:0019722|calcium-mediated signaling;GO:0030183|B cell differentiation;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0032026|response to magnesium ion;GO:0032237|activation of store-operated calcium channel activity;GO:0032481|positive regulation of type I interferon production;GO:0032496|response to lipopolysaccharide;GO:0032733|positive regulation of interleukin-10 production;GO:0032735|positive regulation of interleukin-12 production;GO:0032743|positive regulation of interleukin-2 production;GO:0032747|positive regulation of interleukin-23 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032959|inositol trisphosphate biosynthetic process;GO:0033198|response to ATP;GO:0035556|intracellular signal transduction;GO:0043069|negative regulation of programmed cell death;GO:0043122|regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043410|positive regulation of MAPK cascade;GO:0048678|response to axon injury;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050850|positive regulation of calcium-mediated signaling;GO:0050852|T cell receptor signaling pathway;GO:0050853|B cell receptor signaling pathway;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051209|release of sequestered calcium ion into cytosol;GO:0060100|positive regulation of phagocytosis, engulfment;GO:0060907|positive regulation of macrophage cytokine production;GO:0061760|antifungal innate immune response;GO:0070884|regulation of calcineurin-NFAT signaling cascade;GO:0071277|cellular response to calcium ion;GO:0071396|cellular response to lipid;GO:0150078|positive regulation of neuroinflammatory response;GO:1900227|positive regulation of NLRP3 inflammasome complex assembly;GO:1902808|positive regulation of cell cycle G1/S phase transition;GO:1903428|positive regulation of reactive oxygen species biosynthetic process;GO:1903721|positive regulation of I-kappaB phosphorylation;GO:1990858|cellular response to lectin;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0032587|ruffle membrane;GO:0048471|perinuclear region of cytoplasm;GO:0097708|intracellular vesicle;","GO:0001784|phosphotyrosine residue binding;GO:0004435|phosphatidylinositol phospholipase C activity;GO:0005515|protein binding;GO:0019901|protein kinase binding;GO:0097110|scaffold protein binding;GO:0140031|phosphorylation-dependent protein binding;GO:1990782|protein tyrosine kinase binding;","K05859","PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]"]
["ENSRNOG00000046309",4,0.257321753,174,11.23376358,0.022906104,-5.448124115,{"v":8.20406e-43,"d":"8.20E-43"},{"v":2.3323e-42,"d":"2.33E-42"},"down","yes","Gpr68","protein_coding","chr6:120135436-120166089:-","gi|157820739|ref|NP_001101519.1|",1946,0,"ovarian cancer G-protein coupled receptor 1 [Rattus norvegicus]","gi|157820738|ref|NM_001108049.1|",2960,0,"Rattus norvegicus G protein-coupled receptor 68 (Gpr68), mRNA","Q8BFQ3",707,0,"Ovarian cancer G-protein coupled receptor 1",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0032024|positive regulation of insulin secretion;GO:0035774|positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0045656|negative regulation of monocyte differentiation;GO:0071467|cellular response to pH;GO:2001206|positive regulation of osteoclast development;","GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;","K08408","GPR68, OGR1; ovarian cancer G-protein coupled receptor 1"]
["ENSRNOG00000021611",324,20.84306197,769,49.64807007,0.419816157,-1.252170404,{"v":8.61176e-43,"d":"8.61E-43"},{"v":2.44699E-42,"d":"2.45E-42"},"down","yes","Clip2","protein_coding","chr12:22163218-22227023:+","gi|817474091|ref|NP_068837.2|",4975,0,"CAP-Gly domain-containing linker protein 2 [Rattus norvegicus]","gi|817474090|ref|NM_021997.2|",4829,0,"Rattus norvegicus CAP-GLY domain containing linker protein 2 (Clip2), mRNA","O55156",1896,0,"CAP-Gly domain-containing linker protein 2","ECU06g0410",72.4,{"v":9E-13,"d":"9.00E-13"},"COG5244","pfam01302","CAP_GLY","CAP-Gly domain. Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove.","GO:0007026|negative regulation of microtubule depolymerization;GO:0031122|cytoplasmic microtubule organization;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005881|cytoplasmic microtubule;GO:0015630|microtubule cytoskeleton;GO:0030425|dendrite;GO:0035371|microtubule plus-end;GO:0042599|lamellar body;GO:1901588|dendritic microtubule;","GO:0005515|protein binding;GO:0008017|microtubule binding;GO:0051010|microtubule plus-end binding;","K10422","CLIP2, CYLN2; CAP-Gly domain-containing linker protein 2"]
["ENSRNOG00000000137",43,2.766208842,275,17.75451141,0.155803152,-2.682203673,{"v":8.97401e-43,"d":"8.97E-43"},{"v":2.54865E-42,"d":"2.55E-42"},"down","yes","Ly86","protein_coding","chr17:27415830-27487260:-","gi|157821741|ref|NP_001099598.1|",867,{"v":6e-114,"d":"6.00E-114"},"lymphocyte antigen 86 [Rattus norvegicus]","gi|672081470|ref|XM_006253800.2|",936,0,"PREDICTED: Rattus norvegicus lymphocyte antigen 86 (Ly86), transcript variant X1, mRNA","O88188",265,{"v":5e-87,"d":"5.00E-87"},"Lymphocyte antigen 86",".",".",".",".","pfam02221","E1_DerP2_DerF2","ML domain. ML domain - MD-2-related lipid recognition domain. This family consists of proteins from plants, animals and fungi, including dust mite allergen Der P 2. It has been implicate in lipid recognition, particularly in the recognition of pathogen related products. A mutation in Npc2 causes a rare form of Niemann-Pick type C2 disease. This domain has a similar topology to immunoglobulin domains.","GO:0031666|positive regulation of lipopolysaccharide-mediated signaling pathway;GO:0045087|innate immune response;",".",".",".","."]
["ENSRNOG00000014312",12,0.771965258,194,12.52500077,0.061633949,-4.020130961,{"v":1.21991E-42,"d":"1.22E-42"},{"v":3.45429e-42,"d":"3.45E-42"},"down","yes","AC109737.1","TR_C_gene","chr4:70417612-70418013:+","gi|68533982|gb|AAH99166.1|",697,{"v":8E-90,"d":"8.00E-90"},"Tcrb protein [Rattus norvegicus]","gi|207192|gb|M63795.1|RATTCBC3",390,0,"Rattus norvegicus T-cell receptor beta-chain (Tcrb) gene, exons 1 through 4 and partial cds","P01852",235,{"v":5e-78,"d":"5.00E-78"},"T-cell receptor beta-1 chain C region",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.",".",".",".",".","."]
["ENSRNOG00000004249",46,2.959200157,281,18.14188256,0.163114282,-2.616044984,{"v":1.4978e-42,"d":"1.50E-42"},{"v":4.22856e-42,"d":"4.23E-42"},"down","yes","ENSRNOG00000004249","protein_coding","chrX:27027425-27054754:+","gi|564398991|ref|XP_006256904.1|",4998,0,"PREDICTED: toll-like receptor 7 isoform X2 [Rattus norvegicus]","gi|672087353|ref|XM_008773170.1|",4113,0,"PREDICTED: Rattus norvegicus toll-like receptor 7 (Tlr7), transcript variant X2, mRNA","P58681",1778,0,"Toll-like receptor 7","MA2301_1",53.9,2e-06,"COG4886","pfam01582","TIR","TIR domain. The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.","GO:0000165|MAPK cascade;GO:0001932|regulation of protein phosphorylation;GO:0002224|toll-like receptor signaling pathway;GO:0002755|MyD88-dependent toll-like receptor signaling pathway;GO:0006954|inflammatory response;GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0007252|I-kappaB phosphorylation;GO:0007254|JNK cascade;GO:0032722|positive regulation of chemokine production;GO:0032727|positive regulation of interferon-alpha production;GO:0032728|positive regulation of interferon-beta production;GO:0032729|positive regulation of interferon-gamma production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0034154|toll-like receptor 7 signaling pathway;GO:0045087|innate immune response;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051607|defense response to virus;GO:0071260|cellular response to mechanical stimulus;GO:0098586|cellular response to virus;GO:1901224|positive regulation of NIK/NF-kappaB signaling;","GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0005768|endosome;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0032009|early phagosome;GO:0043235|receptor complex;","GO:0003725|double-stranded RNA binding;GO:0003727|single-stranded RNA binding;GO:0003953|NAD+ nucleosidase activity;GO:0004888|transmembrane signaling receptor activity;GO:0035197|siRNA binding;GO:0038187|pattern recognition receptor activity;","K05404","TLR7; toll-like receptor 7"]
["ENSRNOG00000003649",524,33.70914961,1059,68.37100937,0.493032791,-1.020244492,{"v":2.06309e-42,"d":"2.06E-42"},{"v":5.81301e-42,"d":"5.81E-42"},"down","yes","Qsox1","protein_coding","chr13:67949780-67987459:-","gi|158138547|ref|NP_001103368.1|",3771,0,"sulfhydryl oxidase 1 isoform A precursor [Rattus norvegicus]","gi|158138546|ref|NM_001109898.1|",3272,0,"Rattus norvegicus quiescin sulfhydryl oxidase 1 (Qsox1), transcript variant 1, mRNA","Q6IUU3",1459,0,"Sulfhydryl oxidase 1","SPAC1F5.02",61.2,9e-09,"COG0526","pfam04777","Evr1_Alr","Erv1 / Alr family. Biogenesis of Fe/S clusters involves a number of essential mitochondrial proteins. Erv1p of Saccharomyces cerevisiae mitochondria is required for the maturation of Fe/S proteins in the cytosol. The ALR (augmenter of liver regeneration) represents a mammalian orthologue of yeast Erv1p. Both Erv1p and full-length ALR are located in the mitochondrial intermembrane an d it thought to operate downstream of the mitochondrial ABC transporter.","GO:0006457|protein folding;GO:0016242|negative regulation of macroautophagy;GO:0085029|extracellular matrix assembly;","GO:0000139|Golgi membrane;GO:0005615|extracellular space;GO:0005794|Golgi apparatus;GO:0030173|integral component of Golgi membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0045171|intercellular bridge;GO:0070062|extracellular exosome;","GO:0003756|protein disulfide isomerase activity;GO:0016971|flavin-linked sulfhydryl oxidase activity;GO:0071949|FAD binding;","K10758","QSOX; thiol oxidase [EC:1.8.3.2]"]
["ENSRNOG00000055010",65,4.181478482,322,20.78891881,0.201139776,-2.313729684,{"v":2.31222e-42,"d":"2.31E-42"},{"v":6.50213e-42,"d":"6.50E-42"},"down","yes","Axin2","protein_coding","chr10:93899245-93926231:+","gi|13242243|ref|NP_077331.1|",4026,0,"axin-2 [Rattus norvegicus]","gi|13242242|ref|NM_024355.1|",3154,0,"Rattus norvegicus axin 2 (Axin2), mRNA","O70240",1555,0,"Axin-2",".",".",".",".","pfam00615","RGS","Regulator of G protein signaling domain. RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.","GO:0001756|somitogenesis;GO:0001934|positive regulation of protein phosphorylation;GO:0001957|intramembranous ossification;GO:0003139|secondary heart field specification;GO:0003413|chondrocyte differentiation involved in endochondral bone morphogenesis;GO:0008219|cell death;GO:0008283|cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0010718|positive regulation of epithelial to mesenchymal transition;GO:0010942|positive regulation of cell death;GO:0016055|Wnt signaling pathway;GO:0030111|regulation of Wnt signaling pathway;GO:0030282|bone mineralization;GO:0032423|regulation of mismatch repair;GO:0034613|cellular protein localization;GO:0042476|odontogenesis;GO:0043570|maintenance of DNA repeat elements;GO:0045668|negative regulation of osteoblast differentiation;GO:0045860|positive regulation of protein kinase activity;GO:0048255|mRNA stabilization;GO:0061181|regulation of chondrocyte development;GO:0070602|regulation of centromeric sister chromatid cohesion;GO:0071407|cellular response to organic cyclic compound;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:2000054|negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0032991|protein-containing complex;","GO:0008013|beta-catenin binding;GO:0019899|enzyme binding;GO:0019901|protein kinase binding;GO:0031625|ubiquitin protein ligase binding;GO:0070411|I-SMAD binding;","K04385","AXIN2; axin 2"]
["ENSRNOG00000042592",226,14.53867903,612,39.51185811,0.367957361,-1.4423895,{"v":2.52471e-42,"d":"2.52E-42"},{"v":7.09616e-42,"d":"7.10E-42"},"down","yes","Rgs10","protein_coding","chr1:182946336-182987697:-","gi|564331113|ref|XP_006230387.1|",771,{"v":2E-99,"d":"2.00E-99"},"PREDICTED: regulator of G-protein signaling 10 isoform X1 [Rattus norvegicus]","gi|672038557|ref|XM_006230325.2|",882,0,"PREDICTED: Rattus norvegicus regulator of G-protein signaling 10 (Rgs10), transcript variant X1, mRNA","P49806",295,{"v":4e-98,"d":"4.00E-98"},"Regulator of G-protein signaling 10",".",".",".",".","pfam00615","RGS","Regulator of G protein signaling domain. RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.","GO:0001975|response to amphetamine;GO:0007213|G protein-coupled acetylcholine receptor signaling pathway;GO:0008277|regulation of G protein-coupled receptor signaling pathway;GO:0009968|negative regulation of signal transduction;GO:0043547|positive regulation of GTPase activity;","GO:0005634|nucleus;GO:0005829|cytosol;GO:0043025|neuronal cell body;GO:0043197|dendritic spine;GO:0043679|axon terminus;","GO:0001965|G-protein alpha-subunit binding;GO:0003674|molecular_function;GO:0005096|GTPase activator activity;","K16449","RGS; regulator of G-protein signaling"]
["ENSRNOG00000016177",117,7.526661268,424,27.37422849,0.274954279,-1.862736354,{"v":2.82372E-42,"d":"2.82E-42"},{"v":7.92877e-42,"d":"7.93E-42"},"down","yes","Scara3","protein_coding","chr15:40140161-40172894:-","gi|157817432|ref|NP_001102340.1|",2392,0,"scavenger receptor class A member 3 [Rattus norvegicus]","gi|157817431|ref|NM_001108870.1|",1884,0,"Rattus norvegicus scavenger receptor class A, member 3 (Scara3), mRNA","Q8C850",902,0,"Scavenger receptor class A member 3",".",".",".",".","pfam03157","Glutenin_hmw","High molecular weight glutenin subunit. Members of this family include high molecular weight subunits of glutenin. This group of gluten proteins is thought to be largely responsible for the elastic properties of gluten, and hence, doughs. Indeed, glutenin high molecular weight subunits are classified as elastomeric proteins, because the glutenin network can withstand significant deformations without breaking, and return to the original conformation when the stress is removed. Elastomeric proteins differ considerably in amino acid sequence, but they are all polymers whose subunits consist of elastomeric domains, composed of repeated motifs, and non-elastic domains that mediate cross-linking between the subunits. The elastomeric domain motifs are all rich in glycine residues in addition to other hydrophobic residues. High molecular weight glutenin subunits have an extensive central elastomeric domain, flanked by two terminal non-elastic domains that form disulphide cross-links. The central elastomeric domain is characterized by the following three repeated motifs: PGQGQQ, GYYPTS[P/L]QQ, GQQ. It possesses overlapping beta-turns within and between the repeated motifs, and assumes a regular helical secondary structure with a diameter of approx. 1.9 nm and a pitch of approx. 1.5 nm.","GO:0030198|extracellular matrix organization;","GO:0005615|extracellular space;GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;GO:0031012|extracellular matrix;","GO:0005201|extracellular matrix structural constituent;",".","."]
["ENSRNOG00000062383",147,9.456574413,478,30.86056892,0.306429037,-1.706375083,{"v":3.18171E-42,"d":"3.18E-42"},{"v":8.9252e-42,"d":"8.93E-42"},"down","yes","Dio2","protein_coding","chr6:109665523-109679809:-","gi|132566529|ref|NP_113908.3|",1398,{"v":1E-174,"d":"1.00E-174"},"type II iodothyronine deiodinase [Rattus norvegicus]","gi|2959448|dbj|AB011068.1|",3423,0,"Rattus rattus mRNA for type II iodothyronine deiodinase, complete cds","P70551",543,{"v":4E-176,"d":"4.00E-176"},"Type II iodothyronine deiodinase",".",".",".",".","pfam00837","T4_deiodinase","Iodothyronine deiodinase. Iodothyronine deiodinase converts thyroxine (T4) to 3,5,3'-triiodothyronine (T3).",".",".",".",".","."]
["ENSRNOG00000018681",446,28.69137543,945,61.01095737,0.470265943,-1.088451239,{"v":4.39658e-42,"d":"4.40E-42"},{"v":1.2321E-41,"d":"1.23E-41"},"down","yes","Nes","protein_coding","chr2:173438734-173447777:+","gi|815891005|ref|NP_001295168.1|",8129,0,"nestin isoform 1 [Rattus norvegicus]","gi|815891004|ref|NM_001308239.1|",6213,0,"Rattus norvegicus nestin (Nes), transcript variant 1, mRNA","P21263",3130,0,"Nestin",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0000086|G2/M transition of mitotic cell cycle;GO:0007399|nervous system development;GO:0007420|brain development;GO:0009410|response to xenobiotic stimulus;GO:0010212|response to ionizing radiation;GO:0030182|neuron differentiation;GO:0030844|positive regulation of intermediate filament depolymerization;GO:0031076|embryonic camera-type eye development;GO:0031667|response to nutrient levels;GO:0032091|negative regulation of protein binding;GO:0043086|negative regulation of catalytic activity;GO:0043524|negative regulation of neuron apoptotic process;GO:0048858|cell projection morphogenesis;GO:0072089|stem cell proliferation;GO:2000179|positive regulation of neural precursor cell proliferation;","GO:0005737|cytoplasm;GO:0005882|intermediate filament;GO:0045111|intermediate filament cytoskeleton;","GO:0019215|intermediate filament binding;GO:0031730|CCR5 chemokine receptor binding;","K07609","NES; nestin"]
["ENSRNOG00000049590",24,1.543930516,225,14.52641842,0.106284321,-3.23399931,{"v":4.72874e-42,"d":"4.73E-42"},{"v":1.32454e-41,"d":"1.32E-41"},"down","yes","RT1-M2","protein_coding","chr20:978935-981723:+","gi|48843735|ref|NP_001001717.1|",1588,0,"RT1 class Ib, locus M2 precursor [Rattus norvegicus]","gi|672085524|ref|XM_008772690.1|",1160,0,"PREDICTED: Rattus norvegicus RT1 class Ib, locus M2 (RT1-M2), transcript variant X1, mRNA","P01902",402,{"v":8e-135,"d":"8.00E-135"},"H-2 class I histocompatibility antigen, K-D alpha chain",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.","GO:0001916|positive regulation of T cell mediated cytotoxicity;GO:0002476|antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002486|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0006955|immune response;","GO:0005615|extracellular space;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0005102|signaling receptor binding;GO:0042605|peptide antigen binding;","K06751","MHC1; MHC class I antigen"]
["ENSRNOG00000049766",29,1.865582707,237,15.30116074,0.12192426,-3.035942873,{"v":8.08335e-42,"d":"8.08E-42"},{"v":2.26085e-41,"d":"2.26E-41"},"down","yes","Sctr","protein_coding","chr13:31127858-31180189:+","gi|13592081|ref|NP_112377.1|",2086,0,"secretin receptor precursor [Rattus norvegicus]","gi|51859272|gb|BC081781.1|",1393,0,"Rattus norvegicus secretin receptor, mRNA (cDNA clone MGC:93381 IMAGE:7189388), complete cds","P23811",808,0,"Secretin receptor",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0002024|diet induced thermogenesis;GO:0007166|cell surface receptor signaling pathway;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007188|adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007420|brain development;GO:0009992|cellular water homeostasis;GO:0031667|response to nutrient levels;GO:0032098|regulation of appetite;GO:0043950|positive regulation of cAMP-mediated signaling;GO:0048167|regulation of synaptic plasticity;GO:0050996|positive regulation of lipid catabolic process;GO:0070295|renal water absorption;","GO:0005881|cytoplasmic microtubule;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0008528|G protein-coupled peptide receptor activity;GO:0015055|secretin receptor activity;GO:0017046|peptide hormone binding;GO:0042277|peptide binding;","K04588","SCTR; secretin receptor"]
["ENSRNOG00000002180",504,32.42254085,1026,66.24046801,0.489467267,-1.030715711,{"v":8.2146e-42,"d":"8.21E-42"},{"v":2.29643E-41,"d":"2.30E-41"},"down","yes","Tbc1d1","protein_coding","chr14:43935636-44136499:-","gi|392333035|ref|XP_001071842.3|",6276,0,"PREDICTED: TBC1 domain family member 1 isoform X1 [Rattus norvegicus]","gi|672027908|ref|XM_001071842.5|",5545,0,"PREDICTED: Rattus norvegicus TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 (Tbc1d1), transcript variant X1, mRNA","Q60949",2343,0,"TBC1 domain family member 1",".",".",".",".","pfam00566","RabGAP-TBC","Rab-GTPase-TBC domain. Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.","GO:0006886|intracellular protein transport;GO:0032880|regulation of protein localization;GO:0090630|activation of GTPase activity;",".","GO:0005096|GTPase activator activity;","K18341","TBC1D1; TBC1 domain family member 1"]
["ENSRNOG00000016326",209,13.44506158,580,37.4458786,0.359053174,-1.477730577,{"v":1.28179e-41,"d":"1.28E-41"},{"v":3.57108e-41,"d":"3.57E-41"},"down","yes","Cx3cl1","protein_coding","chr19:10227340-10236833:-","gi|672084211|ref|XP_008770551.1|",1853,0,"PREDICTED: fractalkine isoform X1 [Rattus norvegicus]","gi|672084210|ref|XM_008772329.1|",2973,0,"PREDICTED: Rattus norvegicus chemokine (C-X3-C motif) ligand 1 (Cx3cl1), transcript variant X1, mRNA","O55145",711,0,"Fractalkine",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0001666|response to hypoxia;GO:0001774|microglial cell activation;GO:0002052|positive regulation of neuroblast proliferation;GO:0002523|leukocyte migration involved in inflammatory response;GO:0002548|monocyte chemotaxis;GO:0002931|response to ischemia;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007155|cell adhesion;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007568|aging;GO:0008284|positive regulation of cell proliferation;GO:0010759|positive regulation of macrophage chemotaxis;GO:0010976|positive regulation of neuron projection development;GO:0019221|cytokine-mediated signaling pathway;GO:0030168|platelet activation;GO:0030335|positive regulation of cell migration;GO:0030336|negative regulation of cell migration;GO:0030593|neutrophil chemotaxis;GO:0031664|regulation of lipopolysaccharide-mediated signaling pathway;GO:0032233|positive regulation of actin filament bundle assembly;GO:0032690|negative regulation of interleukin-1 alpha production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032914|positive regulation of transforming growth factor beta1 production;GO:0033622|integrin activation;GO:0035425|autocrine signaling;GO:0042060|wound healing;GO:0043066|negative regulation of apoptotic process;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043410|positive regulation of MAPK cascade;GO:0043547|positive regulation of GTPase activity;GO:0045766|positive regulation of angiogenesis;GO:0045785|positive regulation of cell adhesion;GO:0045906|negative regulation of vasoconstriction;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048245|eosinophil chemotaxis;GO:0048246|macrophage chemotaxis;GO:0048247|lymphocyte chemotaxis;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0050729|positive regulation of inflammatory response;GO:0050902|leukocyte adhesive activation;GO:0050918|positive chemotaxis;GO:0051041|positive regulation of calcium-independent cell-cell adhesion;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;GO:0051897|positive regulation of protein kinase B signaling;GO:0060055|angiogenesis involved in wound healing;GO:0060080|inhibitory postsynaptic potential;GO:0060326|cell chemotaxis;GO:0061518|microglial cell proliferation;GO:0070050|neuron cellular homeostasis;GO:0070098|chemokine-mediated signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0098609|cell-cell adhesion;GO:0110091|negative regulation of hippocampal neuron apoptotic process;GO:1900450|negative regulation of glutamate receptor signaling pathway;GO:1903721|positive regulation of I-kappaB phosphorylation;GO:1903979|negative regulation of microglial cell activation;GO:1904141|positive regulation of microglial cell migration;GO:2001234|negative regulation of apoptotic signaling pathway;GO:2001240|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0042995|cell projection;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0044297|cell body;GO:0048471|perinuclear region of cytoplasm;GO:0098794|postsynapse;","GO:0005178|integrin binding;GO:0008009|chemokine activity;GO:0031737|CX3C chemokine receptor binding;GO:0042056|chemoattractant activity;GO:0045237|CXCR1 chemokine receptor binding;GO:0048020|CCR chemokine receptor binding;","K05508","CX3CL1, NTT; C-X3-C motif chemokine 1"]
["ENSRNOG00000005094",153,9.842557042,485,31.31250193,0.31433314,-1.669633714,{"v":1.43089e-41,"d":"1.43E-41"},{"v":3.98064e-41,"d":"3.98E-41"},"down","yes","C1qtnf7","protein_coding","chr14:67468014-67580410:-","gi|524929326|ref|XP_005068869.1|",1000,{"v":6e-129,"d":"6.00E-129"},"PREDICTED: complement C1q tumor necrosis factor-related protein 7 isoform X1 [Mesocricetus auratus]","gi|672076401|ref|XM_006251073.2|",1660,0,"PREDICTED: Rattus norvegicus C1q and tumor necrosis factor related protein 7 (C1qtnf7), transcript variant X2, mRNA","Q8BVD7",325,{"v":2e-105,"d":"2.00E-105"},"Complement C1q tumor necrosis factor-related protein 7",".",".",".",".","pfam00386","C1q","C1q domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.",".","GO:0005615|extracellular space;","GO:0042802|identical protein binding;","K24218","C1QTNF7; complement C1q and tumor necrosis factor-related protein 7"]
["ENSRNOG00000062846",9,0.578973944,181,11.6856966,0.049545522,-4.335101505,{"v":1.59229E-41,"d":"1.59E-41"},{"v":4.42532e-41,"d":"4.43E-41"},"down","yes","Oas1k","protein_coding","chr12:35762468-35771710:-","gi|564379514|ref|XP_006249463.1|",1380,0,"PREDICTED: 2 ' -5 ' oligoadenylate synthetase 1K isoform X2 [Rattus norvegicus]","gi|57222307|ref|NM_001009489.1|",937,0,"Rattus norvegicus 2 ' -5 ' oligoadenylate synthetase 1K (Oas1k), mRNA","Q05961",387,{"v":2e-127,"d":"2.00E-127"},"2'-5'-oligoadenylate synthase 1A",".",".",".",".","pfam10421","OAS1_C","2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus. This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between 320 and 344 at the extreme C-terminal end. Oligoadenylate synthetases are antiviral enzymes that counteract vial attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesize 2'.5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication. This domain is often associated with NTP_transf_2 pfam01909.",".",".",".",".","."]
["ENSRNOG00000067262",420,27.01878404,903,58.29935927,0.463449073,-1.109517279,{"v":1.66309E-41,"d":"1.66E-41"},{"v":4.61985e-41,"d":"4.62E-41"},"down","yes","Aldh18a1","protein_coding","chr1:239375669-239407890:-","gi|157823607|ref|NP_001101994.1|",4088,0,"delta-1-pyrroline-5-carboxylate synthase [Rattus norvegicus]","gi|564333657|ref|XM_006231344.1|",3345,0,"PREDICTED: Rattus norvegicus aldehyde dehydrogenase 18 family, member A1 (Aldh18a1), transcript variant X1, mRNA","Q9Z110",1559,0,"Delta-1-pyrroline-5-carboxylate synthase","sll0373",297,{"v":9e-89,"d":"9.00E-89"},"COG0014","pfam00696","AA_kinase","Amino acid kinase family. This family includes kinases that phosphorylate a variety of amino acid substrates, as well as uridylate kinase and carbamate kinase. This family includes: Aspartokinase EC:2.7.2.4. Acetylglutamate kinase EC:2.7.2.8. Glutamate 5-kinase EC:2.7.2.11. Uridylate kinase EC:2.7.4.-. Carbamate kinase EC:2.7.2.2.",".",".",".",".","."]
["ENSRNOG00000011517",312,20.07109671,742,47.90489986,0.418977949,-1.255053777,{"v":1.71164e-41,"d":"1.71E-41"},{"v":4.75241e-41,"d":"4.75E-41"},"down","yes","Tnfrsf21","protein_coding","chr9:17879156-17954085:-","gi|157817151|ref|NP_001101677.1|",3201,0,"tumor necrosis factor receptor superfamily member 21 precursor [Rattus norvegicus]","gi|157817150|ref|NM_001108207.1|",4342,0,"Rattus norvegicus tumor necrosis factor receptor superfamily, member 21 (Tnfrsf21), mRNA","D3ZF92",1209,0,"Tumor necrosis factor receptor superfamily member 21",".",".",".",".","pfam00531","Death","Death domain.","GO:0001783|B cell apoptotic process;GO:0002250|adaptive immune response;GO:0006915|apoptotic process;GO:0006959|humoral immune response;GO:0007413|axonal fasciculation;GO:0030889|negative regulation of B cell proliferation;GO:0031642|negative regulation of myelination;GO:0032693|negative regulation of interleukin-10 production;GO:0032696|negative regulation of interleukin-13 production;GO:0032714|negative regulation of interleukin-5 production;GO:0042130|negative regulation of T cell proliferation;GO:0042552|myelination;GO:0048713|regulation of oligodendrocyte differentiation;GO:0050852|T cell receptor signaling pathway;GO:0051402|neuron apoptotic process;GO:0071356|cellular response to tumor necrosis factor;GO:0097252|oligodendrocyte apoptotic process;","GO:0005737|cytoplasm;GO:0005887|integral component of plasma membrane;GO:0030424|axon;GO:0031226|intrinsic component of plasma membrane;",".","K05157","TNFRSF21, DR6, CD358; tumor necrosis factor receptor superfamily member 21"]
["ENSRNOG00000068266",7,0.450313067,175,11.29832544,0.03985662,-4.649036809,{"v":2.03524e-41,"d":"2.04E-41"},{"v":5.64814e-41,"d":"5.65E-41"},"down","yes","Nxpe5","protein_coding","chr12:17097523-17119761:-","gi|564315084|ref|XP_003752620.2|",2793,0,"PREDICTED: NXPE family member 3-like isoform X1 [Rattus norvegicus]","gi|672072433|ref|XM_006249028.2|",1912,0,"PREDICTED: Rattus norvegicus neurexophilin and PC-esterase domain family, member 4 (Nxpe4), transcript variant X3, mRNA","A2VDP6",322,{"v":1E-97,"d":"1.00E-97"},"NXPE family member 3",".",".",".",".","pfam06312","Neurexophilin","Neurexophilin. This family consists of mammalian neurexophilin proteins. Mammalian brains contain four different neurexophilin proteins. Neurexophilins form a family of related glycoproteins that are proteolytically processed after synthesis and bind to alpha-neurexins. The structure and characteristics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins.",".",".",".",".","."]
["ENSRNOG00000021796",25,1.608260955,225,14.52641842,0.110712834,-3.175105621,{"v":2.1295e-41,"d":"2.13E-41"},{"v":5.90399e-41,"d":"5.90E-41"},"down","yes","RGD1565166","protein_coding","chr10:10361948-10371046:+","gi|157786582|ref|NP_001099232.1|",1865,0,"UPF0764 protein C16orf89 homolog precursor [Rattus norvegicus]","gi|157786581|ref|NM_001105762.1|",1529,0,"Rattus norvegicus similar to MGC45438 protein (RGD1565166), mRNA","Q3UST5",647,0,"UPF0764 protein C16orf89 homolog",".",".",".",".",".",".",".",".","GO:0005829|cytosol;GO:0016020|membrane;","GO:0042803|protein homodimerization activity;",".","."]
["ENSRNOG00000017429",47,3.023530595,278,17.94819698,0.168458737,-2.56953284,{"v":2.51752e-41,"d":"2.52E-41"},{"v":6.96963E-41,"d":"6.97E-41"},"down","yes","Lat","protein_coding","chr1:180936534-180941578:-","gi|13540669|ref|NP_110480.1|",829,{"v":3e-106,"d":"3.00E-106"},"linker for activation of T-cells family member 1 [Rattus norvegicus]","gi|13540668|ref|NM_030853.1|",1188,0,"Rattus norvegicus linker for activation of T cells (Lat), mRNA","O70601",323,{"v":1E-107,"d":"1.00E-107"},"Linker for activation of T-cells family member 1",".",".",".",".","pfam15234","LAT","Linker for activation of T-cells.","GO:0002250|adaptive immune response;GO:0002260|lymphocyte homeostasis;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007229|integrin-mediated signaling pathway;GO:0007265|Ras protein signal transduction;GO:0010467|gene expression;GO:0019722|calcium-mediated signaling;GO:0035556|intracellular signal transduction;GO:0043303|mast cell degranulation;GO:0045860|positive regulation of protein kinase activity;GO:0048872|homeostasis of number of cells;GO:0050863|regulation of T cell activation;","GO:0001772|immunological synapse;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0008180|COP9 signalosome;GO:0016021|integral component of membrane;","GO:0019901|protein kinase binding;GO:0030159|receptor signaling complex scaffold activity;","K07362","LAT; linker for activation of T cells"]
["ENSRNOG00000043093",6,0.385982629,172,11.10463986,0.034758681,-4.846482873,{"v":2.56485E-41,"d":"2.56E-41"},{"v":7.09378E-41,"d":"7.09E-41"},"down","yes","Ap1m2","protein_coding","chr8:19838580-19856482:-","gi|160333502|ref|NP_001103770.1|",2242,0,"AP-1 complex subunit mu-2 isoform 1 [Mus musculus]","gi|187937158|ref|NM_001108996.2|",1669,0,"Rattus norvegicus adaptor-related protein complex 1, mu 2 subunit (Ap1m2), mRNA","Q9WVP1",855,0,"AP-1 complex subunit mu-2",".",".",".",".","pfam00928","Adap_comp_sub","Adaptor complexes medium subunit family. This family also contains members which are coatomer subunits.","GO:0006886|intracellular protein transport;GO:0016192|vesicle-mediated transport;","GO:0005794|Golgi apparatus;GO:0030131|clathrin adaptor complex;GO:0030136|clathrin-coated vesicle;GO:0030665|clathrin-coated vesicle membrane;GO:0031410|cytoplasmic vesicle;GO:0043231|intracellular membrane-bounded organelle;","GO:0035615|clathrin adaptor activity;","K12393","AP1M; AP-1 complex subunit mu"]
["ENSRNOG00000011881",91,5.854069875,369,23.82332621,0.245728486,-2.024862985,{"v":3.78918e-41,"d":"3.79E-41"},{"v":1.04597E-40,"d":"1.05E-40"},"down","yes","Slc25a15","protein_coding","chr16:69634414-69653010:+","gi|114145544|ref|NP_001041345.1|",1724,0,"mitochondrial ornithine transporter 1 [Rattus norvegicus]","gi|1002341709|ref|NM_001047880.2|",1018,0,"Rattus norvegicus solute carrier family 25 member 15 (Slc25a15), mRNA","A0A0G2K309",571,0,"Mitochondrial ornithine transporter 1",".",".",".",".","pfam00153","Mito_carr","Mitochondrial carrier protein.","GO:0008150|biological_process;GO:1990575|mitochondrial L-ornithine transmembrane transport;","GO:0005575|cellular_component;GO:0005743|mitochondrial inner membrane;GO:0016021|integral component of membrane;","GO:0000064|L-ornithine transmembrane transporter activity;GO:0003674|molecular_function;","K15101","SLC25A2_15, ORNT; solute carrier family 25 (mitochondrial ornithine transporter) member 2/15"]
["ENSRNOG00000018903",348,22.38699249,794,51.26211657,0.436716117,-1.195232321,{"v":3.95997e-41,"d":"3.96E-41"},{"v":1.09259E-40,"d":"1.09E-40"},"down","yes","Pik3r1","protein_coding","chr2:32882032-32963631:-","gi|537223645|gb|ERE82807.1|",2242,0,"phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform 1 [Cricetulus griseus]","gi|672041186|ref|XM_006231868.2|",2554,0,"PREDICTED: Rattus norvegicus phosphoinositide-3-kinase, regulatory subunit 1 (alpha) (Pik3r1), transcript variant X1, mRNA","Q5R685",791,0,"Phosphatidylinositol 3-kinase regulatory subunit alpha",".",".",".",".","pfam00017","SH2","SH2 domain.","GO:0001678|cellular glucose homeostasis;GO:0001878|response to yeast;GO:0001934|positive regulation of protein phosphorylation;GO:0001953|negative regulation of cell-matrix adhesion;GO:0006006|glucose metabolic process;GO:0006468|protein phosphorylation;GO:0006606|protein import into nucleus;GO:0007162|negative regulation of cell adhesion;GO:0007568|aging;GO:0007584|response to nutrient;GO:0008286|insulin receptor signaling pathway;GO:0008625|extrinsic apoptotic signaling pathway via death domain receptors;GO:0008630|intrinsic apoptotic signaling pathway in response to DNA damage;GO:0009410|response to xenobiotic stimulus;GO:0009750|response to fructose;GO:0010040|response to iron(II) ion;GO:0010459|negative regulation of heart rate;GO:0010592|positive regulation of lamellipodium assembly;GO:0010628|positive regulation of gene expression;GO:0010656|negative regulation of muscle cell apoptotic process;GO:0014065|phosphatidylinositol 3-kinase signaling;GO:0022408|negative regulation of cell-cell adhesion;GO:0030183|B cell differentiation;GO:0030335|positive regulation of cell migration;GO:0032355|response to estradiol;GO:0032570|response to progesterone;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032868|response to insulin;GO:0032869|cellular response to insulin stimulus;GO:0033120|positive regulation of RNA splicing;GO:0033574|response to testosterone;GO:0034644|cellular response to UV;GO:0034976|response to endoplasmic reticulum stress;GO:0036092|phosphatidylinositol-3-phosphate biosynthetic process;GO:0042307|positive regulation of protein import into nucleus;GO:0043066|negative regulation of apoptotic process;GO:0043200|response to amino acid;GO:0043551|regulation of phosphatidylinositol 3-kinase activity;GO:0045471|response to ethanol;GO:0045663|positive regulation of myoblast differentiation;GO:0045671|negative regulation of osteoclast differentiation;GO:0045776|negative regulation of blood pressure;GO:0045861|negative regulation of proteolysis;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046626|regulation of insulin receptor signaling pathway;GO:0046854|phosphatidylinositol phosphorylation;GO:0048009|insulin-like growth factor receptor signaling pathway;GO:0048662|negative regulation of smooth muscle cell proliferation;GO:0050821|protein stabilization;GO:0051384|response to glucocorticoid;GO:0051491|positive regulation of filopodium assembly;GO:0051492|regulation of stress fiber assembly;GO:0051497|negative regulation of stress fiber assembly;GO:0051591|response to cAMP;GO:0051965|positive regulation of synapse assembly;GO:0060396|growth hormone receptor signaling pathway;GO:0070542|response to fatty acid;GO:0070848|response to growth factor;GO:0071398|cellular response to fatty acid;GO:0071548|response to dexamethasone;GO:0120183|positive regulation of focal adhesion disassembly;GO:1900103|positive regulation of endoplasmic reticulum unfolded protein response;GO:1903076|regulation of protein localization to plasma membrane;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005801|cis-Golgi network;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0005942|phosphatidylinositol 3-kinase complex;GO:0005943|phosphatidylinositol 3-kinase complex, class IA;GO:0016020|membrane;GO:0032991|protein-containing complex;GO:0043005|neuron projection;GO:0048471|perinuclear region of cytoplasm;GO:1990578|perinuclear endoplasmic reticulum membrane;","GO:0001784|phosphotyrosine residue binding;GO:0005102|signaling receptor binding;GO:0005158|insulin receptor binding;GO:0005159|insulin-like growth factor receptor binding;GO:0005161|platelet-derived growth factor receptor binding;GO:0005168|neurotrophin TRKA receptor binding;GO:0005515|protein binding;GO:0005516|calmodulin binding;GO:0008022|protein C-terminus binding;GO:0016303|1-phosphatidylinositol-3-kinase activity;GO:0019901|protein kinase binding;GO:0019903|protein phosphatase binding;GO:0019904|protein domain specific binding;GO:0030331|estrogen receptor binding;GO:0030971|receptor tyrosine kinase binding;GO:0031625|ubiquitin protein ligase binding;GO:0035014|phosphatidylinositol 3-kinase regulator activity;GO:0036312|phosphatidylinositol 3-kinase regulatory subunit binding;GO:0043125|ErbB-3 class receptor binding;GO:0043559|insulin binding;GO:0043560|insulin receptor substrate binding;GO:0046935|1-phosphatidylinositol-3-kinase regulator activity;GO:0046982|protein heterodimerization activity;GO:0051117|ATPase binding;GO:0051219|phosphoprotein binding;","K02649","PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta"]
["ENSRNOG00000030212",33,2.12290446,244,15.75309376,0.134761114,-2.891523838,{"v":4.31496E-41,"d":"4.31E-41"},{"v":1.18938E-40,"d":"1.19E-40"},"down","yes","Cerkl","protein_coding","chr3:64237522-64340675:-","gi|148695295|gb|EDL27242.1|",2372,0,"mCG20062, isoform CRA_b, partial [Mus musculus]","gi|672046046|ref|XR_086195.4|",1797,0,"PREDICTED: Rattus norvegicus ceramide kinase-like (Cerkl), transcript variant X2, misc_RNA","Q49MI3",769,0,"Ceramide kinase-like protein",".",".",".",".","pfam00781","DAGK_cat","Diacylglycerol kinase catalytic domain. Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologues. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.","GO:0008150|biological_process;GO:0016310|phosphorylation;GO:0030148|sphingolipid biosynthetic process;GO:0043066|negative regulation of apoptotic process;GO:0046834|lipid phosphorylation;","GO:0001750|photoreceptor outer segment;GO:0001917|photoreceptor inner segment;GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0048471|perinuclear region of cytoplasm;","GO:0003674|molecular_function;GO:0003951|NAD+ kinase activity;GO:0046625|sphingolipid binding;",".","."]
["ENSRNOG00000027264",29,1.865582707,234,15.10747516,0.123487392,-3.017564344,{"v":4.39274e-41,"d":"4.39E-41"},{"v":1.21024e-40,"d":"1.21E-40"},"down","yes","Dagla","protein_coding","chr1:206890638-206947232:-","gi|54312094|ref|NP_001005886.1|",5009,0,"sn1-specific diacylglycerol lipase alpha [Rattus norvegicus]","gi|54312093|ref|NM_001005886.1|",5546,0,"Rattus norvegicus diacylglycerol lipase, alpha (Dagla), mRNA","Q5YLM1",1934,0,"Sn1-specific diacylglycerol lipase alpha",".",".",".",".","pfam01764","Lipase_3","Lipase (class 3).","GO:0007216|G protein-coupled glutamate receptor signaling pathway;GO:0007405|neuroblast proliferation;GO:0019369|arachidonic acid metabolic process;GO:0022008|neurogenesis;GO:0042136|neurotransmitter biosynthetic process;GO:0046340|diacylglycerol catabolic process;GO:0071926|endocannabinoid signaling pathway;GO:0098921|retrograde trans-synaptic signaling by endocannabinoid;GO:0150077|regulation of neuroinflammatory response;","GO:0005886|plasma membrane;GO:0031901|early endosome membrane;GO:0032590|dendrite membrane;GO:0032591|dendritic spine membrane;GO:0043196|varicosity;GO:0045211|postsynaptic membrane;GO:0098839|postsynaptic density membrane;GO:0099055|integral component of postsynaptic membrane;","GO:0016787|hydrolase activity;GO:0046872|metal ion binding;","K13806","DAGL; sn1-specific diacylglycerol lipase [EC:3.1.1.116]"]
["ENSRNOG00000023410",48,3.087861033,279,18.01275884,0.171426324,-2.54433943,{"v":4.92256e-41,"d":"4.92E-41"},{"v":1.3549E-40,"d":"1.35E-40"},"down","yes","Apol9a","protein_coding","chr7:109140871-109147649:-","gi|68163567|ref|NP_001020237.1|",1533,0,"apolipoprotein L 9a [Rattus norvegicus]","gi|68163566|ref|NM_001025066.1|",1568,0,"Rattus norvegicus apolipoprotein L 9a (Apol9a), mRNA","O95236",162,{"v":1E-42,"d":"1.00E-42"},"Apolipoprotein L3",".",".",".",".","pfam05461","ApoL","Apolipoprotein L. Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.","GO:0006869|lipid transport;GO:0042157|lipoprotein metabolic process;","GO:0005576|extracellular region;","GO:0008289|lipid binding;","K14480","APOL; apolipoprotein L"]
["ENSRNOG00000001742",398,25.6035144,867,55.97513232,0.457408734,-1.128444182,{"v":5.63392e-41,"d":"5.63E-41"},{"v":1.54846e-40,"d":"1.55E-40"},"down","yes","Clcn2","protein_coding","chr11:80198153-80211657:+","gi|8393138|ref|NP_058833.1|",4245,0,"chloride channel protein 2 [Rattus norvegicus]","gi|672071540|ref|XM_006248562.2|",3186,0,"PREDICTED: Rattus norvegicus chloride channel, voltage-sensitive 2 (Clcn2), transcript variant X1, mRNA","P35525",1639,0,"Chloride channel protein 2","SPBC887.02",120,{"v":5e-27,"d":"5.00E-27"},"COG0038","pfam00654","Voltage_CLC","Voltage gated chloride channel. This family of ion channels contains 10 or 12 transmembrane helices. Each protein forms a single pore. It has been shown that some members of this family form homodimers. In terms of primary structure, they are unrelated to known cation channels or other types of anion channels. Three ClC subfamilies are found in animals. ClC-1 is involved in setting and restoring the resting membrane potential of skeletal muscle, while other channels play important parts in solute concentration mechanisms in the kidney. These proteins contain two pfam00571 domains.","GO:0006821|chloride transport;GO:0030324|lung development;GO:0032347|regulation of aldosterone biosynthetic process;GO:0034220|ion transmembrane transport;GO:0034765|regulation of ion transmembrane transport;GO:0060041|retina development in camera-type eye;GO:0060689|cell differentiation involved in salivary gland development;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0015629|actin cytoskeleton;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0034707|chloride channel complex;GO:0043204|perikaryon;","GO:0005247|voltage-gated chloride channel activity;","K05011","CLCN2; chloride channel 2"]
["ENSRNOG00000000704",87,5.596748122,359,23.17770762,0.241471168,-2.050077157,{"v":1.06583E-40,"d":"1.07E-40"},{"v":2.92096e-40,"d":"2.92E-40"},"down","yes","Cmklr1","protein_coding","chr12:42974410-43028129:+","gi|83035131|ref|NP_071554.2|",1782,0,"chemokine-like receptor 1 [Rattus norvegicus]","gi|672073389|ref|XM_006249505.2|",5932,0,"PREDICTED: Rattus norvegicus chemokine-like receptor 1 (Cmklr1), transcript variant X1, mRNA","O35786",659,0,"Chemokine-like receptor 1",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0002430|complement receptor mediated signaling pathway;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0010759|positive regulation of macrophage chemotaxis;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0032695|negative regulation of interleukin-12 production;GO:0045600|positive regulation of fat cell differentiation;GO:0050848|regulation of calcium-mediated signaling;GO:0120162|positive regulation of cold-induced thermogenesis;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0001637|G protein-coupled chemoattractant receptor activity;GO:0004875|complement receptor activity;GO:0004930|G protein-coupled receptor activity;GO:0097003|adipokinetic hormone receptor activity;GO:0097004|adipokinetic hormone binding;","K04245","CMKLR1; chemokine-like receptor 1"]
["ENSRNOG00000014761",37,2.380226213,252,16.26958863,0.146299102,-2.773007177,{"v":1.09855E-40,"d":"1.10E-40"},{"v":3.00918e-40,"d":"3.01E-40"},"down","yes","Rasd2","protein_coding","chr19:13594291-13605016:+","gi|537193698|gb|ERE77608.1|",1808,0,"GTP-binding protein Rhes-like protein [Cricetulus griseus]","gi|21717662|ref|NM_133568.1|",3445,0,"Rattus norvegicus RASD family, member 2 (Rasd2), mRNA","P63033",561,0,"GTP-binding protein Rhes",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0001963|synaptic transmission, dopaminergic;GO:0007626|locomotory behavior;GO:0031397|negative regulation of protein ubiquitination;GO:0033235|positive regulation of protein sumoylation;GO:0043949|regulation of cAMP-mediated signaling;GO:0051897|positive regulation of protein kinase B signaling;","GO:0005886|plasma membrane;GO:0045202|synapse;","GO:0003924|GTPase activity;GO:0005515|protein binding;GO:0005525|GTP binding;GO:0031624|ubiquitin conjugating enzyme binding;GO:0031681|G-protein beta-subunit binding;GO:0043548|phosphatidylinositol 3-kinase binding;","K07844","RASD2; RASD family, member 2"]
["ENSRNOG00000016037",321,20.65007066,750,48.42139474,0.426465837,-1.229497918,{"v":1.2063e-40,"d":"1.21E-40"},{"v":3.30275E-40,"d":"3.30E-40"},"down","yes","Mafb","protein_coding","chr3:148998122-149000031:-","gi|31415868|ref|NP_062189.1|",1189,{"v":9e-156,"d":"9.00E-156"},"transcription factor MafB [Rattus norvegicus]","gi|31415867|ref|NM_019316.1|",1893,0,"Rattus norvegicus v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B (Mafb), mRNA","P54842",454,{"v":3e-154,"d":"3.00E-154"},"Transcription factor MafB",".",".",".",".","pfam03131","bZIP_Maf","bZIP Maf transcription factor. Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerization and DNA binding property. Thus, this family is probably related to pfam00170. This family also includes the DNA_binding domain of Skn-1, this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer.","GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007379|segment specification;GO:0007585|respiratory gaseous exchange;GO:0021571|rhombomere 5 development;GO:0021572|rhombomere 6 development;GO:0021599|abducens nerve formation;GO:0033077|T cell differentiation in thymus;GO:0035284|brain segmentation;GO:0042472|inner ear morphogenesis;GO:0045444|fat cell differentiation;GO:0045637|regulation of myeloid cell differentiation;GO:0045647|negative regulation of erythrocyte differentiation;GO:0045671|negative regulation of osteoclast differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048538|thymus development;","GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0005515|protein binding;GO:0042802|identical protein binding;GO:0043565|sequence-specific DNA binding;GO:0044877|protein-containing complex binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09036","MAFB; transcription factor MAFB"]
["ENSRNOG00000019140",250,16.08260955,640,41.31959018,0.389224808,-1.36132443,{"v":1.27222e-40,"d":"1.27E-40"},{"v":3.4799e-40,"d":"3.48E-40"},"down","yes","Banp","protein_coding","chr19:50007881-50082738:+","gi|157822243|ref|NP_001099661.1|",2738,0,"protein BANP [Rattus norvegicus]","gi|672085189|ref|XM_006255751.2|",2324,0,"PREDICTED: Rattus norvegicus Btg3 associated nuclear protein (Banp), transcript variant X1, mRNA","Q8VBU8",1052,0,"Protein BANP",".",".",".",".","pfam10523","BEN","BEN domain. The BEN domain is found in diverse animal proteins such as BANP/SMAR1, NAC1 and the Drosophila mod(mdg4) isoform C, in the chordopoxvirus virosomal protein E5R and in several proteins of polydnaviruses. Computational analysis suggests that the BEN domain mediates protein-DNA and protein-protein interactions during chromatin organisation and transcription.","GO:0034504|protein localization to nucleus;GO:0042177|negative regulation of protein catabolic process;GO:0045893|positive regulation of transcription, DNA-templated;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0016604|nuclear body;","GO:0002039|p53 binding;GO:0003677|DNA binding;GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000002305",13,0.836295696,189,12.20219147,0.068536516,-3.866983325,{"v":1.28431E-40,"d":"1.28E-40"},{"v":3.51131e-40,"d":"3.51E-40"},"down","yes","Slc15a2","protein_coding","chr11:64014182-64043225:+","gi|404312669|ref|NP_113860.2|",3578,0,"solute carrier family 15 member 2 [Rattus norvegicus]","gi|404312668|ref|NM_031672.2|",3881,0,"Rattus norvegicus solute carrier family 15 member 2 (Slc15a2), mRNA","Q63424",1358,0,"Solute carrier family 15 member 2","ECU11g1050",178,{"v":2E-46,"d":"2.00E-46"},"COG3104","pfam00854","PTR2","POT family. The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.","GO:0006857|oligopeptide transport;GO:0015031|protein transport;GO:0015835|peptidoglycan transport;GO:0042908|xenobiotic transport;GO:0042938|dipeptide transport;GO:0045087|innate immune response;GO:0070293|renal absorption;GO:0070424|regulation of nucleotide-binding oligomerization domain containing signaling pathway;GO:0140206|dipeptide import across plasma membrane;GO:1902600|proton transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;","GO:0015333|peptide:proton symporter activity;GO:0015334|high-affinity oligopeptide transmembrane transporter activity;GO:0071916|dipeptide transmembrane transporter activity;","K14637","SLC15A2, PEPT2; solute carrier family 15 (oligopeptide transporter), member 2"]
["ENSRNOG00000018494",103,6.626035133,389,25.11456341,0.263832384,-1.922306437,{"v":1.5472e-40,"d":"1.55E-40"},{"v":4.22396e-40,"d":"4.22E-40"},"down","yes","Ppp1r3c","protein_coding","chr1:234460652-234465961:-","gi|672040239|ref|XP_008758592.1|",1591,0,"PREDICTED: protein phosphatase 1 regulatory subunit 3C isoform X1 [Rattus norvegicus]","gi|672040238|ref|XM_008760370.1|",2651,0,"PREDICTED: Rattus norvegicus protein phosphatase 1, regulatory subunit 3C (Ppp1r3c), transcript variant X1, mRNA","Q5U2R5",614,0,"Protein phosphatase 1 regulatory subunit 3C",".",".",".",".","pfam03370","CBM_21","Putative phosphatase regulatory subunit. This family consists of several eukaryotic proteins that are thought to be involved in the regulation of glycogen metabolizm. For instance, the mouse PTG protein has been shown to interact with glycogen synthase, phosphorylase kinase, phosphorylase a: these three enzymes have key roles in the regulation of glycogen metabolizm. PTG also binds the catalytic subunit of protein phosphatase 1 (PP1C) and localizes it to glycogen. Subsets of similar interactions have been observed with several other members of this family, such as the yeast PIG1, PIG2, GAC1 and GIP2 proteins. While the precise function of these proteins is not known, they may serve a scaffold function, bringing together the key enzymes in glycogen metabolizm. This family is a carbohydrate binding domain.","GO:0005977|glycogen metabolic process;GO:0005978|glycogen biosynthetic process;GO:0005979|regulation of glycogen biosynthetic process;GO:0005981|regulation of glycogen catabolic process;GO:0006470|protein dephosphorylation;","GO:0000164|protein phosphatase type 1 complex;GO:0042587|glycogen granule;GO:0043231|intracellular membrane-bounded organelle;","GO:0004721|phosphoprotein phosphatase activity;GO:0008157|protein phosphatase 1 binding;GO:0019899|enzyme binding;GO:0019903|protein phosphatase binding;GO:0050196|[phosphorylase] phosphatase activity;GO:2001069|glycogen binding;","K07189","PPP1R3; protein phosphatase 1 regulatory subunit 3A/B/C/D/E"]
["ENSRNOG00000018336",32,2.058574022,239,15.43028446,0.133411281,-2.906047427,{"v":1.77291e-40,"d":"1.77E-40"},{"v":4.83324e-40,"d":"4.83E-40"},"down","yes","Eps8l2","protein_coding","chr1:196446287-196471541:+","gi|564331756|ref|XP_006230624.1|",3703,0,"PREDICTED: epidermal growth factor receptor kinase substrate 8-like protein 2 isoform X1 [Rattus norvegicus]","gi|564331755|ref|XM_006230562.1|",3019,0,"PREDICTED: Rattus norvegicus EPS8-like 2 (Eps8l2), transcript variant X1, mRNA","Q99K30",1394,0,"Epidermal growth factor receptor kinase substrate 8-like protein 2",".",".",".",".","pfam08416","PTB","Phosphotyrosine-binding domain. The phosphotyrosine-binding domain (PTB, also phosphotyrosine-interaction or PI domain) in the protein tensin tends to be found at the C-terminus. Tensin is a multi-domain protein that binds to actin filaments and functions as a focal-adhesion molecule (focal adhesions are regions of plasma membrane through which cells attach to the extracellular matrix). Human tensin has actin-binding sites, an SH2 (pfam00017) domain and a region similar to the tumor suppressor PTEN. The PTB domain interacts with the cytoplasmic tails of beta integrin by binding to an NPXY motif.","GO:0007266|Rho protein signal transduction;GO:0007605|sensory perception of sound;GO:0035023|regulation of Rho protein signal transduction;GO:0050790|regulation of catalytic activity;GO:1900029|positive regulation of ruffle assembly;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0032421|stereocilium bundle;GO:0032426|stereocilium tip;GO:0032587|ruffle membrane;GO:0032991|protein-containing complex;","GO:0003779|actin binding;GO:0005085|guanyl-nucleotide exchange factor activity;","K17277","EPS8; epidermal growth factor receptor kinase substrate 8"]
["ENSRNOG00000017369",183,11.77247019,530,34.21778562,0.344045355,-1.539329331,{"v":1.90363e-40,"d":"1.90E-40"},{"v":5.18467e-40,"d":"5.18E-40"},"down","yes","Mustn1","protein_coding","chr16:6072833-6075161:+","gi|149034210|gb|EDL88980.1|",542,{"v":3e-62,"d":"3.00E-62"},"musculoskeletal, embryonic nuclear protein 1 [Rattus norvegicus]","gi|41055442|ref|NM_181368.3|",811,0,"Rattus norvegicus musculoskeletal, embryonic nuclear protein 1 (Mustn1), mRNA","Q80XX4",162,{"v":1e-45,"d":"1.00E-45"},"Musculoskeletal embryonic nuclear protein 1",".",".",".",".","pfam07822","Toxin_13","Neurotoxin B-IV-like protein. The members of this family resemble neurotoxin B-IV, which is a crustacean-selective neurotoxin produced by the marine worm Cerebratulus lacteus. This highly cationic peptide is approximately 55 residues and is arranged to form two antiparallel helices connected by a well-defined loop in a hairpin structure. The branches of the hairpin are linked by four disulphide bonds. Three residues identified as being important for activity, namely Arg-17, -25 and -34, are found on the same face of the molecule, while another residue important for activity, Trp30, is on the opposite side. The protein's mode of action is not entirely understood, but it may act on voltage-gated sodium channels, possibly by binding to an as yet uncharacterized site on these proteins. Its site of interaction may also be less specific, for example it may interact with negatively charged membrane lipids.","GO:0002062|chondrocyte differentiation;GO:0010628|positive regulation of gene expression;GO:0030326|embryonic limb morphogenesis;GO:0032332|positive regulation of chondrocyte differentiation;GO:0035988|chondrocyte proliferation;GO:0042060|wound healing;GO:0042246|tissue regeneration;GO:1902730|positive regulation of proteoglycan biosynthetic process;GO:1902732|positive regulation of chondrocyte proliferation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;",".",".","."]
["ENSRNOG00000068731",15,0.964956573,194,12.52500077,0.077042436,-3.698202866,{"v":1.94542E-40,"d":"1.95E-40"},{"v":5.29596e-40,"d":"5.30E-40"},"down","yes","ENSRNOG00000068731","lncRNA","chr5:145217884-145221870:+","gi|148704753|gb|EDL36700.1|",232,{"v":7e-19,"d":"7.00E-19"},"mCG146313, partial [Mus musculus]","gi|23956420|emb|AL627184.18|",580,0,"Mouse DNA sequence from clone RP23-125F21 on chromosome 4, complete sequence",".",".",".",".",".",".",".",".","pfam15180","NPBW","Neuropeptides B and W. The function of this family, NPBW, which includes Neuropeptides B and W, is thought to be involved in activating G-protein coupled receptors, GPR7 and GPR8. It is thought to play a regulatory role in the organisation of neuroendocrine signals accessing the anterior pituitary gland. It is predicted that this effect will stimulate the increase in water-drinking and food-intake. This suggests it plays a role in the hypothalamic response to stress. This family of proteins is found in eukaryotes.",".",".",".",".","."]
["ENSRNOG00000013564",92,5.918400313,367,23.69420249,0.249782634,-2.001254916,{"v":2.43362E-40,"d":"2.43E-40"},{"v":6.61865e-40,"d":"6.62E-40"},"down","yes","Dok3","protein_coding","chr17:9109597-9115188:+","gi|157823803|ref|NP_001100806.1|",1790,0,"docking protein 3 [Rattus norvegicus]","gi|74217653|dbj|AK156060.1|",1457,0,"Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830006H02 product:Adaptor protein (Inhibitory adapter molecule DOK3) homolog [Mus musculus], full insert sequence","B2RYG7",694,0,"Docking protein 3",".",".",".",".","pfam02174","IRS","PTB domain (IRS-1 type).","GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007265|Ras protein signal transduction;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;",".","K24036","DOK3; docking protein 3"]
["ENSRNOG00000014365",384,24.70288826,840,54.23196211,0.455504232,-1.134463636,{"v":4.42827e-40,"d":"4.43E-40"},{"v":1.19807E-39,"d":"1.20E-39"},"down","yes","Gne","protein_coding","chr5:58267210-58307499:-","gi|237681189|ref|NP_056643.3|",3292,0,"bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform 2 [Mus musculus]","gi|672052429|ref|XM_006238009.2|",2311,0,"PREDICTED: Rattus norvegicus glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (Gne), transcript variant X3, mRNA","O35826",1271,0,"Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase","Cj1142",159,{"v":3e-41,"d":"3.00E-41"},"COG0381","pfam02350","Epimerase_2","UDP-N-acetylglucosamine 2-epimerase. This family consists of UDP-N-acetylglucosamine 2-epimerases EC:5.1.3.14 this enzyme catalyses the production of UDP-ManNAc from UDP-GlcNAc. Note that some of the enzymes is this family are bifunctional; in this instance Pfam matches only the N-terminal half of the protein suggesting that the additional C-terminal part (when compared to mono-functional members of this family) is responsible for the UPD-N-acetylmannosamine kinase activity of these enzymes. This hypothesis is further supported by the assumption that the C-terminal part of rat UDP-GlcNAc-2-epimerase is the kinase domain.","GO:0006045|N-acetylglucosamine biosynthetic process;GO:0006047|UDP-N-acetylglucosamine metabolic process;GO:0046380|N-acetylneuraminate biosynthetic process;GO:0046835|carbohydrate phosphorylation;","GO:0005829|cytosol;","GO:0004553|hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0008761|UDP-N-acetylglucosamine 2-epimerase activity;GO:0009384|N-acylmannosamine kinase activity;GO:0046872|metal ion binding;","K12409","GNE; bifunctional UDP-N-acetylglucosamine 2-epimerase / N-acetylmannosamine kinase [EC:3.2.1.183 2.7.1.60]"]
["ENSRNOG00000005731",251,16.14693998,638,41.19046646,0.392006728,-1.351049679,{"v":4.70788e-40,"d":"4.71E-40"},{"v":1.27311E-39,"d":"1.27E-39"},"down","yes","Birc3","protein_coding","chr8:5000845-5015802:-","gi|347921974|ref|NP_076477.3|",3220,0,"baculoviral IAP repeat-containing protein 3 [Rattus norvegicus]","gi|347921973|ref|NM_023987.3|",2618,0,"Rattus norvegicus baculoviral IAP repeat-containing 3 (Birc3), mRNA","O08863",1049,0,"Baculoviral IAP repeat-containing protein 3",".",".",".",".","pfam00653","BIR","Inhibitor of Apoptosis domain. BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteristically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.","GO:0006915|apoptotic process;GO:0007283|spermatogenesis;GO:0016567|protein ubiquitination;GO:0031398|positive regulation of protein ubiquitination;GO:0042326|negative regulation of phosphorylation;GO:0042981|regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0051726|regulation of cell cycle;GO:0060544|regulation of necroptotic process;GO:0060546|negative regulation of necroptotic process;GO:0070266|necroptotic process;GO:0071356|cellular response to tumor necrosis factor;GO:1901222|regulation of NIK/NF-kappaB signaling;GO:1902916|positive regulation of protein polyubiquitination;GO:2000378|negative regulation of reactive oxygen species metabolic process;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0032991|protein-containing complex;GO:0045121|membrane raft;","GO:0004842|ubiquitin-protein transferase activity;GO:0016740|transferase activity;GO:0043027|cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0044877|protein-containing complex binding;GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;","K16060","BIRC2_3; baculoviral IAP repeat-containing protein 2/3"]
["ENSRNOG00000019675",76,4.889113302,334,21.56366112,0.226729277,-2.140957398,{"v":4.80498e-40,"d":"4.80E-40"},{"v":1.29876E-39,"d":"1.30E-39"},"down","yes","Pycard","protein_coding","chr1:182601174-182602955:-","gi|149067648|gb|EDM17200.1|",894,{"v":1e-116,"d":"1.00E-116"},"PYD and CARD domain containing [Rattus norvegicus]","gi|298915386|emb|FQ226280.1|",421,0,"Rattus norvegicus TL0AEA2YL13 mRNA sequence","Q9EPB4",273,{"v":8e-89,"d":"8.00E-89"},"Apoptosis-associated speck-like protein containing a CARD",".",".",".",".","pfam02758","PYRIN","PAAD/DAPIN/Pyrin domain. This domain is predicted to contain 6 alpha helices and to have the same fold as the pfam00531 domain. This similarity may mean that this is a protein-protein interaction domain.","GO:0001773|myeloid dendritic cell activation;GO:0002218|activation of innate immune response;GO:0002230|positive regulation of defense response to virus by host;GO:0002277|myeloid dendritic cell activation involved in immune response;GO:0002588|positive regulation of antigen processing and presentation of peptide antigen via MHC class II;GO:0002821|positive regulation of adaptive immune response;GO:0006915|apoptotic process;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006954|inflammatory response;GO:0009617|response to bacterium;GO:0010506|regulation of autophagy;GO:0010803|regulation of tumor necrosis factor-mediated signaling pathway;GO:0030838|positive regulation of actin filament polymerization;GO:0031647|regulation of protein stability;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0032688|negative regulation of interferon-beta production;GO:0032722|positive regulation of chemokine production;GO:0032729|positive regulation of interferon-gamma production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032733|positive regulation of interleukin-10 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0033209|tumor necrosis factor-mediated signaling pathway;GO:0042104|positive regulation of activated T cell proliferation;GO:0042771|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0042981|regulation of apoptotic process;GO:0043065|positive regulation of apoptotic process;GO:0043087|regulation of GTPase activity;GO:0043124|negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043280|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043281|regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0044351|macropinocytosis;GO:0045087|innate immune response;GO:0046330|positive regulation of JNK cascade;GO:0050727|regulation of inflammatory response;GO:0050766|positive regulation of phagocytosis;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:0050870|positive regulation of T cell activation;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051260|protein homooligomerization;GO:0051607|defense response to virus;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071222|cellular response to lipopolysaccharide;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071901|negative regulation of protein serine/threonine kinase activity;GO:0072332|intrinsic apoptotic signaling pathway by p53 class mediator;GO:0090200|positive regulation of release of cytochrome c from mitochondria;GO:0097202|activation of cysteine-type endopeptidase activity;GO:1900016|negative regulation of cytokine production involved in inflammatory response;GO:2000406|positive regulation of T cell migration;GO:2001056|positive regulation of cysteine-type endopeptidase activity;GO:2001238|positive regulation of extrinsic apoptotic signaling pathway;GO:2001242|regulation of intrinsic apoptotic signaling pathway;","GO:0000139|Golgi membrane;GO:0005576|extracellular region;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;GO:0008385|IkappaB kinase complex;GO:0032991|protein-containing complex;GO:0043025|neuronal cell body;GO:0061702|inflammasome complex;GO:0072558|NLRP1 inflammasome complex;GO:0072559|NLRP3 inflammasome complex;GO:0097169|AIM2 inflammasome complex;","GO:0002020|protease binding;GO:0005138|interleukin-6 receptor binding;GO:0005515|protein binding;GO:0005523|tropomyosin binding;GO:0017024|myosin I binding;GO:0019899|enzyme binding;GO:0032090|Pyrin domain binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0044325|ion channel binding;GO:0046983|protein dimerization activity;GO:0070700|BMP receptor binding;GO:0097153|cysteine-type endopeptidase activity involved in apoptotic process;","K12799","PYCARD, ASC; apoptosis-associated speck-like protein containing a CARD"]
["ENSRNOG00000024243",169,10.87184405,504,32.53917727,0.334115518,-1.581581107,{"v":4.95443e-40,"d":"4.95E-40"},{"v":1.33788e-39,"d":"1.34E-39"},"down","yes","Cadm4","protein_coding","chr1:80075202-80097423:+","gi|114052915|ref|NP_001040572.1|",1967,0,"cell adhesion molecule 4 precursor [Rattus norvegicus]","gi|141802508|ref|NM_153112.3|",1842,0,"Mus musculus cell adhesion molecule 4 (Cadm4), mRNA","Q1WIM1",761,0,"Cell adhesion molecule 4",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0001932|regulation of protein phosphorylation;GO:0001933|negative regulation of protein phosphorylation;GO:0007155|cell adhesion;GO:0010801|negative regulation of peptidyl-threonine phosphorylation;GO:0030948|negative regulation of vascular endothelial growth factor receptor signaling pathway;GO:0035020|regulation of Rac protein signal transduction;GO:0042127|regulation of cell proliferation;GO:0050732|negative regulation of peptidyl-tyrosine phosphorylation;GO:0061041|regulation of wound healing;GO:1900747|negative regulation of vascular endothelial growth factor signaling pathway;GO:2000145|regulation of cell motility;","GO:0016021|integral component of membrane;GO:0031252|cell leading edge;GO:0044291|cell-cell contact zone;","GO:0019903|protein phosphatase binding;GO:0030971|receptor tyrosine kinase binding;GO:0043183|vascular endothelial growth factor receptor 1 binding;GO:0043184|vascular endothelial growth factor receptor 2 binding;","K06783","CADM4, IGSF4C, TSLL2; cell adhesion molecule 4"]
["ENSRNOG00000013578",124,7.976974335,425,27.43879035,0.290718878,-1.78230334,{"v":5.45551e-40,"d":"5.46E-40"},{"v":1.4725e-39,"d":"1.47E-39"},"down","yes","Trem2","protein_coding","chr9:12647259-12654170:-","gi|564367094|ref|XP_006244487.1|",987,{"v":2e-129,"d":"2.00E-129"},"PREDICTED: triggering receptor expressed on myeloid cells 2 isoform X2 [Rattus norvegicus]","gi|672064257|ref|XM_006244425.2|",982,0,"PREDICTED: Rattus norvegicus triggering receptor expressed on myeloid cells 2 (Trem2), transcript variant X2, mRNA","Q99NH8",322,{"v":2e-106,"d":"2.00E-106"},"Triggering receptor expressed on myeloid cells 2",".",".",".",".","pfam07223","DUF1421","Protein of unknown function (DUF1421). This family represents a conserved region approximately 350 residues long within a number of plant proteins of unknown function.","GO:0001774|microglial cell activation;GO:0001934|positive regulation of protein phosphorylation;GO:0002282|microglial cell activation involved in immune response;GO:0002588|positive regulation of antigen processing and presentation of peptide antigen via MHC class II;GO:0002862|negative regulation of inflammatory response to antigenic stimulus;GO:0002931|response to ischemia;GO:0006910|phagocytosis, recognition;GO:0006911|phagocytosis, engulfment;GO:0007613|memory;GO:0010468|regulation of gene expression;GO:0010507|negative regulation of autophagy;GO:0010628|positive regulation of gene expression;GO:0010822|positive regulation of mitochondrion organization;GO:0010875|positive regulation of cholesterol efflux;GO:0010887|negative regulation of cholesterol storage;GO:0010891|negative regulation of sequestering of triglyceride;GO:0010983|positive regulation of high-density lipoprotein particle clearance;GO:0014067|negative regulation of phosphatidylinositol 3-kinase signaling;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0019216|regulation of lipid metabolic process;GO:0030316|osteoclast differentiation;GO:0032006|regulation of TOR signaling;GO:0032008|positive regulation of TOR signaling;GO:0032497|detection of lipopolysaccharide;GO:0032499|detection of peptidoglycan;GO:0032675|regulation of interleukin-6 production;GO:0032691|negative regulation of interleukin-1 beta production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032733|positive regulation of interleukin-10 production;GO:0033674|positive regulation of kinase activity;GO:0034136|negative regulation of toll-like receptor 2 signaling pathway;GO:0034144|negative regulation of toll-like receptor 4 signaling pathway;GO:0034151|regulation of toll-like receptor 6 signaling pathway;GO:0034241|positive regulation of macrophage fusion;GO:0034351|negative regulation of glial cell apoptotic process;GO:0035176|social behavior;GO:0038160|CXCL12-activated CXCR4 signaling pathway;GO:0042742|defense response to bacterium;GO:0043066|negative regulation of apoptotic process;GO:0043124|negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043277|apoptotic cell clearance;GO:0045088|regulation of innate immune response;GO:0045672|positive regulation of osteoclast differentiation;GO:0045728|respiratory burst after phagocytosis;GO:0045960|positive regulation of complement activation, classical pathway;GO:0048143|astrocyte activation;GO:0048678|response to axon injury;GO:0050714|positive regulation of protein secretion;GO:0050730|regulation of peptidyl-tyrosine phosphorylation;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050766|positive regulation of phagocytosis;GO:0050829|defense response to Gram-negative bacterium;GO:0050850|positive regulation of calcium-mediated signaling;GO:0050866|negative regulation of cell activation;GO:0050921|positive regulation of chemotaxis;GO:0055088|lipid homeostasis;GO:0060075|regulation of resting membrane potential;GO:0060100|positive regulation of phagocytosis, engulfment;GO:0061518|microglial cell proliferation;GO:0061889|negative regulation of astrocyte activation;GO:0070269|pyroptosis;GO:0070345|negative regulation of fat cell proliferation;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070392|detection of lipoteichoic acid;GO:0071223|cellular response to lipoteichoic acid;GO:0071224|cellular response to peptidoglycan;GO:0071333|cellular response to glucose stimulus;GO:0071396|cellular response to lipid;GO:0071456|cellular response to hypoxia;GO:0071640|regulation of macrophage inflammatory protein 1 alpha production;GO:0097028|dendritic cell differentiation;GO:0097062|dendritic spine maintenance;GO:0097242|amyloid-beta clearance;GO:0098657|import into cell;GO:0110089|regulation of hippocampal neuron apoptotic process;GO:0120035|regulation of plasma membrane bounded cell projection organization;GO:0140052|cellular response to oxidised low-density lipoprotein particle stimulus;GO:0150062|complement-mediated synapse pruning;GO:0150076|neuroinflammatory response;GO:0150078|positive regulation of neuroinflammatory response;GO:0150079|negative regulation of neuroinflammatory response;GO:0150094|amyloid-beta clearance by cellular catabolic process;GO:1900015|regulation of cytokine production involved in inflammatory response;GO:1900016|negative regulation of cytokine production involved in inflammatory response;GO:1900223|positive regulation of amyloid-beta clearance;GO:1900226|negative regulation of NLRP3 inflammasome complex assembly;GO:1901076|positive regulation of engulfment of apoptotic cell;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1901800|positive regulation of proteasomal protein catabolic process;GO:1901980|positive regulation of inward rectifier potassium channel activity;GO:1902227|negative regulation of macrophage colony-stimulating factor signaling pathway;GO:1902531|regulation of intracellular signal transduction;GO:1903078|positive regulation of protein localization to plasma membrane;GO:1903082|positive regulation of C-C chemokine receptor CCR7 signaling pathway;GO:1903376|regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway;GO:1903753|negative regulation of p38MAPK cascade;GO:1903980|positive regulation of microglial cell activation;GO:1904093|negative regulation of autophagic cell death;GO:1904141|positive regulation of microglial cell migration;GO:1904646|cellular response to amyloid-beta;GO:1904951|positive regulation of establishment of protein localization;GO:1905291|positive regulation of CAMKK-AMPK signaling cascade;GO:1905581|positive regulation of low-density lipoprotein particle clearance;GO:1905805|excitatory synapse pruning;GO:1905808|positive regulation of synapse pruning;GO:1905907|negative regulation of amyloid fibril formation;GO:2000350|positive regulation of CD40 signaling pathway;GO:2001171|positive regulation of ATP biosynthetic process;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;GO:0031226|intrinsic component of plasma membrane;GO:0044853|plasma membrane raft;","GO:0001530|lipopolysaccharide binding;GO:0001540|amyloid-beta binding;GO:0001786|phosphatidylserine binding;GO:0004888|transmembrane signaling receptor activity;GO:0005543|phospholipid binding;GO:0008035|high-density lipoprotein particle binding;GO:0008429|phosphatidylethanolamine binding;GO:0019209|kinase activator activity;GO:0030169|low-density lipoprotein particle binding;GO:0034185|apolipoprotein binding;GO:0034186|apolipoprotein A-I binding;GO:0034189|very-low-density lipoprotein particle binding;GO:0038023|signaling receptor activity;GO:0042834|peptidoglycan binding;GO:0044877|protein-containing complex binding;GO:0070891|lipoteichoic acid binding;GO:0071813|lipoprotein particle binding;GO:0097110|scaffold protein binding;GO:0120146|sulfatide binding;GO:1990782|protein tyrosine kinase binding;","K14378","TREM2; triggering receptor expressed on myeloid cells 2"]
["ENSRNOG00000004409",51,3.280852347,281,18.14188256,0.180844096,-2.467181598,{"v":5.83437e-40,"d":"5.83E-40"},{"v":1.57401e-39,"d":"1.57E-39"},"down","yes","Sash3","protein_coding","chrX:127326859-127341519:+","gi|564400662|ref|XP_006257592.1|",1589,0,"PREDICTED: SAM and SH3 domain-containing protein 3 isoform X1 [Rattus norvegicus]","gi|672088568|ref|XM_006257530.2|",2562,0,"PREDICTED: Rattus norvegicus SAM and SH3 domain containing 3 (Sash3), transcript variant X1, mRNA","Q8K352",592,0,"SAM and SH3 domain-containing protein 3",".",".",".",".","pfam12485","SLY","Lymphocyte signaling adaptor protein. This domain family is found in eukaryotes, and is typically between 144 and 156 amino acids in length. The family is found in association with pfam07647, pfam07653. There is a conserved LGKK sequence motif. SLY contains a Src homology 3 domain and a sterile alpha motif, suggesting that it functions as a signaling adaptor protein in lymphocytes.","GO:0002639|positive regulation of immunoglobulin production;GO:0002726|positive regulation of T cell cytokine production;GO:0002821|positive regulation of adaptive immune response;GO:0030890|positive regulation of B cell proliferation;GO:0032729|positive regulation of interferon-gamma production;GO:0032733|positive regulation of interleukin-10 production;GO:0032743|positive regulation of interleukin-2 production;GO:0032753|positive regulation of interleukin-4 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0042102|positive regulation of T cell proliferation;GO:0043372|positive regulation of CD4-positive, alpha-beta T cell differentiation;GO:0046622|positive regulation of organ growth;GO:0048873|homeostasis of number of cells within a tissue;GO:0051251|positive regulation of lymphocyte activation;","GO:0005634|nucleus;GO:0005737|cytoplasm;",".","K23706","SASH3; SAM and SH3 domain-containing protein 3"]
["ENSRNOG00000028238",38,2.444556651,251,16.20502677,0.15085175,-2.72879666,{"v":6.9583e-40,"d":"6.96E-40"},{"v":1.87281e-39,"d":"1.87E-39"},"down","yes","Sh3bgr","protein_coding","chr11:35503725-35527853:+","gi|19171129|emb|CAC81660.1|",724,{"v":2E-90,"d":"2.00E-90"},"putative SH3BGR protein [Mus musculus]","gi|672070656|ref|XM_006248184.2|",1190,0,"PREDICTED: Rattus norvegicus SH3 domain binding glutamate-rich protein (Sh3bgr), transcript variant X1, mRNA","Q9WUZ7",249,{"v":6E-79,"d":"6.00E-79"},"SH3 domain-binding glutamic acid-rich protein",".",".",".",".","pfam04908","SH3BGR","SH3-binding, glutamic acid-rich protein.",".",".",".","K23740","SH3BGR; SH3 domain-binding glutamic acid-rich protein"]
["ENSRNOG00000028016",80,5.146435055,341,22.01559414,0.233763169,-2.096880453,{"v":7.85485e-40,"d":"7.85E-40"},{"v":2.11312E-39,"d":"2.11E-39"},"down","yes","Ncf2","protein_coding","chr13:64955503-64986277:+","gi|386655991|gb|AFJ19026.1|",2604,0,"neutrophil cytosolic factor 2 [Rattus norvegicus]","gi|386655992|gb|JN864042.1|",1581,0,"Rattus norvegicus strain BN neutrophil cytosolic factor 2 (Ncf2) mRNA, complete cds","O70145",946,0,"Neutrophil cytosol factor 2",".",".",".",".","pfam00018","SH3_1","SH3 domain. SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta barrel.","GO:0006909|phagocytosis;GO:0007568|aging;GO:0009410|response to xenobiotic stimulus;GO:0009749|response to glucose;GO:0014070|response to organic cyclic compound;GO:0014823|response to activity;GO:0032496|response to lipopolysaccharide;GO:0032570|response to progesterone;GO:0032870|cellular response to hormone stimulus;GO:0033993|response to lipid;GO:0034616|response to laminar fluid shear stress;GO:0042554|superoxide anion generation;GO:0043525|positive regulation of neuron apoptotic process;GO:0045730|respiratory burst;GO:0045777|positive regulation of blood pressure;GO:0050790|regulation of catalytic activity;GO:0055093|response to hyperoxia;","GO:0001669|acrosomal vesicle;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016020|membrane;GO:0043020|NADPH oxidase complex;","GO:0003674|molecular_function;GO:0008022|protein C-terminus binding;GO:0016175|superoxide-generating NADPH oxidase activity;GO:0016176|superoxide-generating NADPH oxidase activator activity;GO:0031267|small GTPase binding;","K08010","NCF2, P67PHOX; neutrophil cytosolic factor 2"]
["ENSRNOG00000020349",165,10.6145223,496,32.02268239,0.331468869,-1.593054715,{"v":8.05071e-40,"d":"8.05E-40"},{"v":2.16479E-39,"d":"2.16E-39"},"down","yes","Rab3il1","protein_coding","chr1:206646155-206679972:+","gi|19705545|ref|NP_599238.1|",1834,0,"guanine nucleotide exchange factor for Rab-3A [Rattus norvegicus]","gi|569007977|ref|XM_006527418.1|",1499,0,"PREDICTED: Mus musculus RAB3A interacting protein (rabin3)-like 1 (Rab3il1), transcript variant X10, mRNA","Q99NH3",711,0,"Guanine nucleotide exchange factor for Rab-3A",".",".",".",".","pfam06428","Sec2p","GDP/GTP exchange factor Sec2p. In Saccharomyces cerevisiae, Sec2p is a GDP/GTP exchange factor for Sec4p, which is required for vesicular transport at the post-Golgi stage of yeast secretion.","GO:0006887|exocytosis;GO:0015031|protein transport;GO:0050790|regulation of catalytic activity;","GO:0070319|Golgi to plasma membrane transport vesicle;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0005515|protein binding;GO:0019900|kinase binding;GO:0042802|identical protein binding;","K16779","RAB3IP, RABIN8; Rab-3A-interacting protein"]
["ENSRNOG00000049331",8,0.514643505,171,11.040078,0.04661593,-4.423033134,{"v":1.08228E-39,"d":"1.08E-39"},{"v":2.90471E-39,"d":"2.90E-39"},"down","yes","RGD1559588","protein_coding","chr12:17398915-17404795:+","gi|564323537|ref|XP_003754688.2|",958,{"v":7E-125,"d":"7.00E-125"},"PREDICTED: LOW QUALITY PROTEIN: paired immunoglobulin-like type 2 receptor beta isoform X1 [Rattus norvegicus]","gi|672072497|ref|XM_008769088.1|",759,0,"PREDICTED: Rattus norvegicus similar to cell surface receptor FDFACT (RGD1561730), transcript variant X2, mRNA","Q2YFS2",248,{"v":3e-78,"d":"3.00E-78"},"Paired immunoglobulin-like type 2 receptor beta",".",".",".",".","pfam09988","DUF2227","Uncharacterized metal-binding protein (DUF2227). Members of this family of hypothetical bacterial proteins possess metal binding properties; however, their exact function has not, as yet, been determined.",".","GO:0016021|integral component of membrane;","GO:0042288|MHC class I protein binding;",".","."]
["ENSRNOG00000008837",401,25.79650571,862,55.65232302,0.46352972,-1.109266252,{"v":1.09776e-39,"d":"1.10E-39"},{"v":2.94488e-39,"d":"2.94E-39"},"down","yes","Ass1","protein_coding","chr3:14747368-14796903:+","gi|795329564|ref|XP_011826543.1|",2173,0,"PREDICTED: argininosuccinate synthase isoform X2 [Mandrillus leucophaeus]","gi|672044859|ref|XM_006233911.2|",1651,0,"PREDICTED: Rattus norvegicus argininosuccinate synthase 1 (Ass1), transcript variant X1, mRNA","P09034",834,0,"Argininosuccinate synthase","TM1780",479,{"v":2e-164,"d":"2.00E-164"},"COG0137","pfam00764","Arginosuc_synth","Arginosuccinate synthase. This family contains a PP-loop motif.","GO:0000050|urea cycle;GO:0000052|citrulline metabolic process;GO:0000053|argininosuccinate metabolic process;GO:0001822|kidney development;GO:0001889|liver development;GO:0006526|arginine biosynthetic process;GO:0006531|aspartate metabolic process;GO:0006953|acute-phase response;GO:0007494|midgut development;GO:0007568|aging;GO:0007584|response to nutrient;GO:0007623|circadian rhythm;GO:0009410|response to xenobiotic stimulus;GO:0009636|response to toxic substance;GO:0010043|response to zinc ion;GO:0010046|response to mycotoxin;GO:0014075|response to amine;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0043200|response to amino acid;GO:0043434|response to peptide hormone;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0048545|response to steroid hormone;GO:0051384|response to glucocorticoid;GO:0060416|response to growth hormone;GO:0060539|diaphragm development;GO:0070542|response to fatty acid;GO:0071222|cellular response to lipopolysaccharide;GO:0071230|cellular response to amino acid stimulus;GO:0071242|cellular response to ammonium ion;GO:0071320|cellular response to cAMP;GO:0071346|cellular response to interferon-gamma;GO:0071356|cellular response to tumor necrosis factor;GO:0071377|cellular response to glucagon stimulus;GO:0071400|cellular response to oleic acid;GO:0071418|cellular response to amine stimulus;GO:0071499|cellular response to laminar fluid shear stress;GO:0071549|cellular response to dexamethasone stimulus;GO:1903038|negative regulation of leukocyte cell-cell adhesion;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0005764|lysosome;GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0070852|cell body fiber;","GO:0004055|argininosuccinate synthase activity;GO:0005524|ATP binding;GO:0015643|toxic substance binding;GO:0016597|amino acid binding;GO:0042802|identical protein binding;","K01940","argG, ASS1; argininosuccinate synthase [EC:6.3.4.5]"]
["ENSRNOG00000057855",18,1.157947887,199,12.84781007,0.090128036,-3.471880238,{"v":1.40272e-39,"d":"1.40E-39"},{"v":3.75592e-39,"d":"3.76E-39"},"down","yes","F5","protein_coding","chr13:76513255-76582317:+","gi|6679731|ref|NP_032002.1|",9537,0,"coagulation factor V preproprotein [Mus musculus]","gi|806392427|ref|NM_007976.3|",4727,0,"Mus musculus coagulation factor V (F5), mRNA","O88783",3678,0,"Coagulation factor V",".",".",".",".","pfam00754","F5_F8_type_C","F5/8 type C domain. This domain is also known as the discoidin (DS) domain family.","GO:0006826|iron ion transport;GO:0007596|blood coagulation;GO:0007598|blood coagulation, extrinsic pathway;GO:0008015|blood circulation;GO:0032571|response to vitamin K;GO:0055072|iron ion homeostasis;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0031091|platelet alpha granule;","GO:0005507|copper ion binding;GO:0016491|oxidoreductase activity;","K03902","F5; coagulation factor V (labile factor)"]
["ENSRNOG00000006855",28,1.801252269,225,14.52641842,0.123998374,-3.011606889,{"v":1.68845E-39,"d":"1.69E-39"},{"v":4.51462e-39,"d":"4.51E-39"},"down","yes","Padi4","protein_coding","chr5:153041352-153074362:-","gi|8393941|ref|NP_058923.1|",3519,0,"protein-arginine deiminase type-4 [Rattus norvegicus]","gi|8393940|ref|NM_017227.1|",2258,0,"Rattus norvegicus peptidyl arginine deiminase, type IV (Padi4), mRNA","O88807",1360,0,"Protein-arginine deiminase type-4",".",".",".",".","pfam03068","PAD","Protein-arginine deiminase (PAD). Members of this family are found in mammals. In the presence of calcium ions, PAD enzymes EC:3.5.3.15 catalyse the post-translational modification reaction responsible for the formation of citrulline residues: Protein L-arginine + H2O <=> Protein L-citrulline + NH3. Several types are recognized (and included in the family) on the basis of molecular mass, substrate specificity, and tissue localisation. The expression of type I PAD is known to be under the control of oestrogen.","GO:0006325|chromatin organization;GO:0006334|nucleosome assembly;GO:0006338|chromatin remodeling;GO:0018101|protein citrullination;GO:0019827|stem cell population maintenance;GO:0036413|histone H3-R26 citrullination;GO:0036414|histone citrullination;GO:0045087|innate immune response;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0032991|protein-containing complex;","GO:0004668|protein-arginine deiminase activity;GO:0005509|calcium ion binding;GO:0034618|arginine binding;GO:0042802|identical protein binding;","K24669","PADI4, PAD4; protein-arginine deiminase 4 [EC:3.5.3.15]"]
["ENSRNOG00000033220",28,1.801252269,225,14.52641842,0.123998374,-3.011606889,{"v":1.68845E-39,"d":"1.69E-39"},{"v":4.51462e-39,"d":"4.51E-39"},"down","yes","Oas1k","protein_coding","chr12:35724055-35735242:-","gi|148747317|ref|NP_653353.2|",1709,0,"inactive 2'-5'-oligoadenylate synthase 1B [Rattus norvegicus]","gi|3192926|gb|AF068268.1|",2111,0,"Rattus norvegicus 2'5' oligoadenylate synthetase-2 mRNA, complete cds","Q5BKD0",662,0,"Inactive 2'-5'-oligoadenylate synthase 1B",".",".",".",".","pfam10421","OAS1_C","2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus. This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between 320 and 344 at the extreme C-terminal end. Oligoadenylate synthetases are antiviral enzymes that counteract vial attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesize 2'.5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication. This domain is often associated with NTP_transf_2 pfam01909.","GO:0009615|response to virus;GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0051607|defense response to virus;GO:0060700|regulation of ribonuclease activity;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005789|endoplasmic reticulum membrane;GO:0005829|cytosol;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0001730|2'-5'-oligoadenylate synthetase activity;GO:0003725|double-stranded RNA binding;","K14216","OAS; 2'-5'-oligoadenylate synthetase [EC:2.7.7.84]"]
["ENSRNOG00000007415",104,6.690365571,385,24.85631597,0.269161592,-1.893455537,{"v":2.28163E-39,"d":"2.28E-39"},{"v":6.09216e-39,"d":"6.09E-39"},"down","yes","Ptgs1","protein_coding","chr3:19584015-19605586:+","gi|577861042|ref|NP_058739.4|",2932,0,"prostaglandin G/H synthase 1 precursor [Rattus norvegicus]","gi|577861041|ref|NM_017043.4|",2781,0,"Rattus norvegicus prostaglandin-endoperoxide synthase 1 (Ptgs1), mRNA","Q63921",1111,0,"Prostaglandin G/H synthase 1",".",".",".",".","pfam03098","An_peroxidase","Animal haem peroxidase.","GO:0001516|prostaglandin biosynthetic process;GO:0006693|prostaglandin metabolic process;GO:0006954|inflammatory response;GO:0006979|response to oxidative stress;GO:0007568|aging;GO:0007612|learning;GO:0007613|memory;GO:0008217|regulation of blood pressure;GO:0010243|response to organonitrogen compound;GO:0010700|negative regulation of norepinephrine secretion;GO:0019233|sensory perception of pain;GO:0019371|cyclooxygenase pathway;GO:0032811|negative regulation of epinephrine secretion;GO:0035633|maintenance of permeability of blood-brain barrier;GO:0042127|regulation of cell proliferation;GO:0045907|positive regulation of vasoconstriction;GO:0045987|positive regulation of smooth muscle contraction;GO:0051412|response to corticosterone;GO:0070542|response to fatty acid;GO:0098869|cellular oxidant detoxification;","GO:0001750|photoreceptor outer segment;GO:0005635|nuclear envelope;GO:0005737|cytoplasm;GO:0005789|endoplasmic reticulum membrane;GO:0005794|Golgi apparatus;GO:0043231|intracellular membrane-bounded organelle;","GO:0004601|peroxidase activity;GO:0004666|prostaglandin-endoperoxide synthase activity;GO:0020037|heme binding;GO:0046872|metal ion binding;GO:0051213|dioxygenase activity;","K00509","PTGS1, COX1; prostaglandin-endoperoxide synthase 1 [EC:1.14.99.1]"]
["ENSRNOG00000056944",64,4.117148044,306,19.75592905,0.208400629,-2.262568462,{"v":2.57408e-39,"d":"2.57E-39"},{"v":6.8666e-39,"d":"6.87E-39"},"down","yes","Arhgap24","protein_coding","chr14:6800631-7183823:-","gi|672075706|ref|XP_008768240.1|",3161,0,"PREDICTED: rho GTPase-activating protein 24 isoform X2 [Rattus norvegicus]","gi|672075705|ref|XM_008770018.1|",3550,0,"PREDICTED: Rattus norvegicus Rho GTPase activating protein 24 (Arhgap24), transcript variant X4, mRNA","Q5U2Z7",1205,0,"Rho GTPase-activating protein 24",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0001525|angiogenesis;GO:0007165|signal transduction;GO:0030154|cell differentiation;GO:0035021|negative regulation of Rac protein signal transduction;GO:0035313|wound healing, spreading of epidermal cells;GO:0050790|regulation of catalytic activity;GO:0090630|activation of GTPase activity;GO:1900028|negative regulation of ruffle assembly;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005912|adherens junction;GO:0005925|focal adhesion;GO:0042995|cell projection;","GO:0005096|GTPase activator activity;","K20642","ARHGAP22_24_25; Rho GTPase-activating protein 22/24/25"]
["ENSRNOG00000004964",6,0.385982629,164,10.58814498,0.036454226,-4.777770123,{"v":2.68361E-39,"d":"2.68E-39"},{"v":7.15208e-39,"d":"7.15E-39"},"down","yes","Erbb3","protein_coding","chr7:996225-1015525:-","gi|149029663|gb|EDL84834.1|",6383,0,"v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian), isoform CRA_a [Rattus norvegicus]","gi|451958072|ref|NM_017218.3|",4199,0,"Rattus norvegicus erb-b2 receptor tyrosine kinase 3 (Erbb3), mRNA","Q62799",2458,0,"Receptor tyrosine-protein kinase erbB-3",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0003197|endocardial cushion development;GO:0007162|negative regulation of cell adhesion;GO:0007165|signal transduction;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007173|epidermal growth factor receptor signaling pathway;GO:0007275|multicellular organism development;GO:0007399|nervous system development;GO:0007409|axonogenesis;GO:0007422|peripheral nervous system development;GO:0007519|skeletal muscle tissue development;GO:0007623|circadian rhythm;GO:0008284|positive regulation of cell proliferation;GO:0009410|response to xenobiotic stimulus;GO:0009611|response to wounding;GO:0009968|negative regulation of signal transduction;GO:0010628|positive regulation of gene expression;GO:0014037|Schwann cell differentiation;GO:0014065|phosphatidylinositol 3-kinase signaling;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0021545|cranial nerve development;GO:0032869|cellular response to insulin stimulus;GO:0033674|positive regulation of kinase activity;GO:0042127|regulation of cell proliferation;GO:0042476|odontogenesis;GO:0043524|negative regulation of neuron apoptotic process;GO:0043586|tongue development;GO:0046326|positive regulation of glucose import;GO:0051048|negative regulation of secretion;GO:0051402|neuron apoptotic process;GO:0055025|positive regulation of cardiac muscle tissue development;GO:0060056|mammary gland involution;GO:0061098|positive regulation of protein tyrosine kinase activity;GO:0070886|positive regulation of calcineurin-NFAT signaling cascade;GO:0097192|extrinsic apoptotic signaling pathway in absence of ligand;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005887|integral component of plasma membrane;GO:0009925|basal plasma membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0016328|lateral plasma membrane;GO:0038143|ERBB3:ERBB2 complex;GO:0043235|receptor complex;GO:0045177|apical part of cell;GO:0045211|postsynaptic membrane;","GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0005524|ATP binding;GO:0019838|growth factor binding;GO:0030296|protein tyrosine kinase activator activity;GO:0031625|ubiquitin protein ligase binding;GO:0038131|neuregulin receptor activity;GO:0038132|neuregulin binding;GO:0042802|identical protein binding;GO:0043125|ErbB-3 class receptor binding;GO:0046982|protein heterodimerization activity;","K05084","ERBB3, HER3; receptor tyrosine-protein kinase erbB-3 [EC:2.7.10.1]"]
["ENSRNOG00000049714",274,17.62654006,669,43.19188411,0.408098429,-1.293010937,{"v":2.76179e-39,"d":"2.76E-39"},{"v":7.35702e-39,"d":"7.36E-39"},"down","yes","Asap3","protein_coding","chr5:148433494-148474073:+","gi|109477515|ref|XP_001069024.1|",4407,0,"PREDICTED: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X1 [Rattus norvegicus]","gi|564306306|ref|XM_001069024.4|",3825,0,"PREDICTED: Rattus norvegicus similar to development and differentiation enhancing factor-like 1 (LOC684122), transcript variant X1, mRNA","Q5U464",1602,0,"Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3","SPAC26A3.10_2",83.2,{"v":3e-16,"d":"3.00E-16"},"COG5347","pfam01412","ArfGap","Putative GTPase activating protein for Arf. Putative zinc fingers with GTPase activating proteins (GAPs) towards the small GTPase, Arf. The GAP of ARD1 stimulates GTPase hydrolysis for ARD1 but not ARFs.","GO:0016477|cell migration;GO:0043547|positive regulation of GTPase activity;GO:0051492|regulation of stress fiber assembly;","GO:0001726|ruffle;GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0005925|focal adhesion;GO:0043231|intracellular membrane-bounded organelle;","GO:0005096|GTPase activator activity;GO:0046872|metal ion binding;","K12488","ASAP; Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein"]
["ENSRNOG00000012481",37,2.380226213,246,15.88221748,0.149867373,-2.738241759,{"v":2.92594e-39,"d":"2.93E-39"},{"v":7.78702e-39,"d":"7.79E-39"},"down","yes","Ppm1j","protein_coding","chr2:192278517-192283882:+","gi|672043716|ref|XP_008759602.1|",2583,0,"PREDICTED: protein phosphatase 1J isoform X1 [Rattus norvegicus]","gi|672043715|ref|XM_008761380.1|",1834,0,"PREDICTED: Rattus norvegicus protein phosphatase, Mg2+/Mn2+ dependent, 1J (Ppm1j), transcript variant X1, mRNA","Q641Y6",916,0,"Protein phosphatase 1J",".",".",".",".","pfam00481","PP2C","Protein phosphatase 2C. Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.","GO:0006470|protein dephosphorylation;",".","GO:0004722|protein serine/threonine phosphatase activity;","K17504","PPM1J, PP2CZ; protein phosphatase 1J [EC:3.1.3.16]"]
["ENSRNOG00000019560",496,31.90789734,994,64.1744885,0.497205324,-1.008086351,{"v":3.61602e-39,"d":"3.62E-39"},{"v":9.61015e-39,"d":"9.61E-39"},"down","yes","Pde2a","protein_coding","chr1:155813180-155915434:+","gi|219803038|ref|NP_001137319.1|",4846,0,"cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3 [Rattus norvegicus]","gi|219803037|ref|NM_001143847.1|",4116,0,"Rattus norvegicus phosphodiesterase 2A (Pde2a), transcript variant 1, mRNA","Q922S4",1852,0,"cGMP-dependent 3',5'-cyclic phosphodiesterase",".",".",".",".","pfam00233","PDEase_I","3'5'-cyclic nucleotide phosphodiesterase.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0003170|heart valve development;GO:0003279|cardiac septum development;GO:0003281|ventricular septum development;GO:0007165|signal transduction;GO:0007193|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007507|heart development;GO:0010628|positive regulation of gene expression;GO:0010749|regulation of nitric oxide mediated signal transduction;GO:0010752|regulation of cGMP-mediated signaling;GO:0010754|negative regulation of cGMP-mediated signaling;GO:0010821|regulation of mitochondrion organization;GO:0019933|cAMP-mediated signaling;GO:0019934|cGMP-mediated signaling;GO:0030224|monocyte differentiation;GO:0035904|aorta development;GO:0036006|cellular response to macrophage colony-stimulating factor stimulus;GO:0043116|negative regulation of vascular permeability;GO:0043117|positive regulation of vascular permeability;GO:0043949|regulation of cAMP-mediated signaling;GO:0043951|negative regulation of cAMP-mediated signaling;GO:0046069|cGMP catabolic process;GO:0050729|positive regulation of inflammatory response;GO:0060548|negative regulation of cell death;GO:0060976|coronary vasculature development;GO:0061028|establishment of endothelial barrier;GO:0071222|cellular response to lipopolysaccharide;GO:0071260|cellular response to mechanical stimulus;GO:0071320|cellular response to cAMP;GO:0071321|cellular response to cGMP;GO:0071466|cellular response to xenobiotic stimulus;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0090324|negative regulation of oxidative phosphorylation;GO:0097011|cellular response to granulocyte macrophage colony-stimulating factor stimulus;GO:1904613|cellular response to 2,3,7,8-tetrachlorodibenzodioxine;GO:1904880|response to hydrogen sulfide;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0005743|mitochondrial inner membrane;GO:0005759|mitochondrial matrix;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0042734|presynaptic membrane;GO:0045121|membrane raft;GO:0048471|perinuclear region of cytoplasm;GO:0097060|synaptic membrane;GO:0097457|hippocampal mossy fiber;","GO:0000287|magnesium ion binding;GO:0004114|3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0004115|3',5'-cyclic-AMP phosphodiesterase activity;GO:0004118|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity;GO:0005515|protein binding;GO:0008270|zinc ion binding;GO:0030552|cAMP binding;GO:0030553|cGMP binding;GO:0030911|TPR domain binding;GO:0036004|GAF domain binding;GO:0042301|phosphate ion binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0046872|metal ion binding;GO:0047555|3',5'-cyclic-GMP phosphodiesterase activity;","K18283","PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase [EC:3.1.4.17]"]
["ENSRNOG00000018276",87,5.596748122,351,22.66121274,0.246974784,-2.017564344,{"v":4.74995e-39,"d":"4.75E-39"},{"v":1.25769e-38,"d":"1.26E-38"},"down","yes","Mgat4a","protein_coding","chr9:39673430-39766890:-","gi|237512962|ref|NP_001153627.1|",2794,0,"alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform 1 [Rattus norvegicus]","gi|237512961|ref|NM_001160155.1|",7190,0,"Rattus norvegicus mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A (Mgat4a), transcript variant 1, mRNA","Q812G0",1068,0,"Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A",".",".",".",".","pfam04666","Glyco_transf_54","N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region. The complex-type of oligosaccharides are synthesized through elongation by glycosyltransferases after trimming of the precursor oligosaccharides transferred to proteins in the endoplasmic reticulum. N-Acetylglucosaminyltransferases (GnTs) take part in the formation of branches in the biosynthesis of complex-type sugar chains. In vertebrates, six GnTs, designated as GnT-I to -VI, which catalyse the transfer of GlcNAc to the core mannose residues of Asn-linked sugar chains, have been identified. GnT-IV (EC:2.4.1.145) catalyses the transfer of GlcNAc from UDP-GlcNAc to the GlcNAc1-2Man1-3 arm of core oligosaccharide [Gn2(22)core oligosaccharide] and forms GlcNAc1-4(GlcNAc1-2)Man1-3 structure on the core oligosaccharide (Gn3(2,4,2)core oligosaccharide). In some members the conserved region occupies all but the very for N-terminal, where there is a signal sequence on all members. For other members the conserved region does not occupy the entire protein but is still to the N-terminus of the protein.","GO:0006487|protein N-linked glycosylation;GO:0008150|biological_process;","GO:0000139|Golgi membrane;GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005783|endoplasmic reticulum;GO:0005793|endoplasmic reticulum-Golgi intermediate compartment;GO:0005795|Golgi stack;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0008375|acetylglucosaminyltransferase activity;GO:0008454|alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity;GO:0016757|transferase activity, transferring glycosyl groups;GO:0046872|metal ion binding;","K00738","MGAT4A_B; alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase A/B [EC:2.4.1.145]"]
["ENSRNOG00000023657",105,6.754696009,384,24.79175411,0.272457365,-1.875897602,{"v":8.39677e-39,"d":"8.40E-39"},{"v":2.21304e-38,"d":"2.21E-38"},"down","yes","Gprin3","protein_coding","chr4:88563607-88657429:-","gi|392339954|ref|XP_002726416.2|",3786,0,"PREDICTED: G protein-regulated inducer of neurite outgrowth 3 isoform X1 [Rattus norvegicus]","gi|672018373|ref|XM_008775748.1|",5285,0,"PREDICTED: Rattus norvegicus GPRIN family member 3 (Gprin3), transcript variant X5, mRNA",".",".",".",".",".",".",".",".","pfam15235","GRIN_C","G protein-regulated inducer of neurite outgrowth C-terminus. This represents the C-terminus of the G protein-regulated inducer of neurite outgrowth proteins.","GO:0031175|neuron projection development;","GO:0005886|plasma membrane;",".",".","."]
["ENSRNOG00000001302",52,3.345182786,278,17.94819698,0.186379879,-2.423681974,{"v":8.74271e-39,"d":"8.74E-39"},{"v":2.30315E-38,"d":"2.30E-38"},"down","yes","Adora2a","protein_coding","chr20:13315853-13333386:-","gi|78126172|ref|NP_445746.3|",1930,0,"adenosine receptor A2a [Rattus norvegicus]","gi|675269485|ref|NM_053294.4|",2485,0,"Rattus norvegicus adenosine A2a receptor (Adora2a), mRNA","P30543",748,0,"Adenosine receptor A2a",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001963|synaptic transmission, dopaminergic;GO:0001973|adenosine receptor signaling pathway;GO:0001975|response to amphetamine;GO:0006355|regulation of transcription, DNA-templated;GO:0006469|negative regulation of protein kinase activity;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007205|protein kinase C-activating G protein-coupled receptor signaling pathway;GO:0007271|synaptic transmission, cholinergic;GO:0007626|locomotory behavior;GO:0008285|negative regulation of cell proliferation;GO:0009410|response to xenobiotic stimulus;GO:0014049|positive regulation of glutamate secretion;GO:0014057|positive regulation of acetylcholine secretion, neurotransmission;GO:0014061|regulation of norepinephrine secretion;GO:0031000|response to caffeine;GO:0032230|positive regulation of synaptic transmission, GABAergic;GO:0035249|synaptic transmission, glutamatergic;GO:0035810|positive regulation of urine volume;GO:0035815|positive regulation of renal sodium excretion;GO:0040013|negative regulation of locomotion;GO:0042311|vasodilation;GO:0042755|eating behavior;GO:0043116|negative regulation of vascular permeability;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043279|response to alkaloid;GO:0043524|negative regulation of neuron apoptotic process;GO:0045938|positive regulation of circadian sleep/wake cycle, sleep;GO:0046636|negative regulation of alpha-beta T cell activation;GO:0048143|astrocyte activation;GO:0048812|neuron projection morphogenesis;GO:0050714|positive regulation of protein secretion;GO:0050728|negative regulation of inflammatory response;GO:0051881|regulation of mitochondrial membrane potential;GO:0051899|membrane depolarization;GO:0051924|regulation of calcium ion transport;GO:0051968|positive regulation of synaptic transmission, glutamatergic;GO:0060079|excitatory postsynaptic potential;GO:0060080|inhibitory postsynaptic potential;GO:0060134|prepulse inhibition;GO:1900273|positive regulation of long-term synaptic potentiation;GO:2000300|regulation of synaptic vesicle exocytosis;GO:2001235|positive regulation of apoptotic signaling pathway;","GO:0000139|Golgi membrane;GO:0005882|intermediate filament;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0012505|endomembrane system;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0030673|axolemma;GO:0032279|asymmetric synapse;GO:0042734|presynaptic membrane;GO:0043025|neuronal cell body;GO:0045211|postsynaptic membrane;GO:0048786|presynaptic active zone;GO:0098978|glutamatergic synapse;GO:0099055|integral component of postsynaptic membrane;GO:0099056|integral component of presynaptic membrane;","GO:0001609|G protein-coupled adenosine receptor activity;GO:0005515|protein binding;GO:0019899|enzyme binding;GO:0031802|type 5 metabotropic glutamate receptor binding;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;GO:0051393|alpha-actinin binding;","K04266","ADORA2A, ADOR; adenosine receptor A2a"]
["ENSRNOG00000014956",171,11.00050493,500,32.28092983,0.340774104,-1.553112389,{"v":9.80049e-39,"d":"9.80E-39"},{"v":2.57943e-38,"d":"2.58E-38"},"down","yes","Slc11a1","protein_coding","chr9:75957316-75968101:+","gi|564369044|ref|XP_006245281.1|",2746,0,"PREDICTED: natural resistance-associated macrophage protein 1 isoform X1 [Rattus norvegicus]","gi|672065608|ref|XM_006245219.2|",1886,0,"PREDICTED: Rattus norvegicus solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 (Slc11a1), transcript variant X1, mRNA","P41251",995,0,"Natural resistance-associated macrophage protein 1","mlr2501",266,{"v":2E-79,"d":"2.00E-79"},"COG1914","pfam01566","Nramp","Natural resistance-associated macrophage protein. The natural resistance-associated macrophage protein (NRAMP) family consists of Nramp1, Nramp2, and yeast proteins Smf1 and Smf2. The NRAMP family is a novel family of functional related proteins defined by a conserved hydrophobic core of ten transmembrane domains. This family of membrane proteins are divalent cation transporters. Nramp1 is an integral membrane protein expressed exclusively in cells of the immune system and is recruited to the membrane of a phagosome upon phagocytosis. By controlling divalent cation concentrations Nramp1 may regulate the interphagosomal replication of bacteria. Mutations in Nramp1 may genetically predispose an individual to susceptibility to diseases including leprosy and tuberculosis conversely this might however provide protection form rheumatoid arthritis. Nramp2 is a multiple divalent cation transporter for Fe2+, Mn2+ and Zn2+ amongst others it is expressed at high levels in the intestine; and is major transferrin-independent iron uptake system in mammals. The yeast proteins Smf1 and Smf2 may also transport divalent cations.","GO:0000165|MAPK cascade;GO:0001818|negative regulation of cytokine production;GO:0001819|positive regulation of cytokine production;GO:0002309|T cell proliferation involved in immune response;GO:0002606|positive regulation of dendritic cell antigen processing and presentation;GO:0002827|positive regulation of T-helper 1 type immune response;GO:0006826|iron ion transport;GO:0006828|manganese ion transport;GO:0006876|cellular cadmium ion homeostasis;GO:0006879|cellular iron ion homeostasis;GO:0006909|phagocytosis;GO:0006954|inflammatory response;GO:0007035|vacuolar acidification;GO:0008150|biological_process;GO:0009617|response to bacterium;GO:0010628|positive regulation of gene expression;GO:0015707|nitrite transport;GO:0030001|metal ion transport;GO:0032147|activation of protein kinase activity;GO:0032496|response to lipopolysaccharide;GO:0032729|positive regulation of interferon-gamma production;GO:0034341|response to interferon-gamma;GO:0034755|iron ion transmembrane transport;GO:0042060|wound healing;GO:0042116|macrophage activation;GO:0042742|defense response to bacterium;GO:0042832|defense response to protozoan;GO:0045342|MHC class II biosynthetic process;GO:0045730|respiratory burst;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048002|antigen processing and presentation of peptide antigen;GO:0048255|mRNA stabilization;GO:0050766|positive regulation of phagocytosis;GO:0050829|defense response to Gram-negative bacterium;GO:0055072|iron ion homeostasis;GO:0060586|multicellular organismal iron ion homeostasis;GO:0070574|cadmium ion transmembrane transport;GO:0070839|divalent metal ion export;GO:0071421|manganese ion transmembrane transport;GO:1902023|L-arginine transport;","GO:0005575|cellular_component;GO:0005764|lysosome;GO:0005770|late endosome;GO:0005886|plasma membrane;GO:0010008|endosome membrane;GO:0016021|integral component of membrane;GO:0030670|phagocytic vesicle membrane;GO:0070821|tertiary granule membrane;","GO:0003674|molecular_function;GO:0005381|iron ion transmembrane transporter activity;GO:0005384|manganese ion transmembrane transporter activity;GO:0015086|cadmium ion transmembrane transporter activity;GO:0042803|protein homodimerization activity;GO:0046873|metal ion transmembrane transporter activity;GO:0046915|transition metal ion transmembrane transporter activity;GO:0051139|metal ion:proton antiporter activity;","K12347","SLC11A1, NRAMP1; natural resistance-associated macrophage protein 1"]
["ENSRNOG00000020339",31,1.994243584,229,14.78466586,0.134885942,-2.890188097,{"v":1.17921E-38,"d":"1.18E-38"},{"v":3.09932e-38,"d":"3.10E-38"},"down","yes","Neurl1","protein_coding","chr1:246067100-246152903:+","gi|564334033|ref|XP_006231573.1|",2659,0,"PREDICTED: E3 ubiquitin-protein ligase NEURL1 isoform X2 [Rattus norvegicus]","gi|672040465|ref|XM_006231511.2|",3472,0,"PREDICTED: Rattus norvegicus neuralized E3 ubiquitin protein ligase 1 (Neurl1), transcript variant X2, mRNA","Q923S6",993,0,"E3 ubiquitin-protein ligase NEURL1",".",".",".",".","pfam07177","Neuralized","Neuralized. This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.","GO:0006417|regulation of translation;GO:0006513|protein monoubiquitination;GO:0007288|sperm axoneme assembly;GO:0007399|nervous system development;GO:0007420|brain development;GO:0007519|skeletal muscle tissue development;GO:0007595|lactation;GO:0008285|negative regulation of cell proliferation;GO:0030317|flagellated sperm motility;GO:0043065|positive regulation of apoptotic process;GO:0045741|positive regulation of epidermal growth factor-activated receptor activity;GO:0045746|negative regulation of Notch signaling pathway;GO:0048170|positive regulation of long-term neuronal synaptic plasticity;GO:0051491|positive regulation of filopodium assembly;GO:0060999|positive regulation of dendritic spine development;GO:0071230|cellular response to amino acid stimulus;GO:0090129|positive regulation of synapse maturation;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0043197|dendritic spine;GO:0043204|perikaryon;GO:0097440|apical dendrite;","GO:0003674|molecular_function;GO:0004842|ubiquitin-protein transferase activity;GO:0045183|translation factor activity, non-nucleic acid binding;GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;","K01931","NEUR; protein neuralized [EC:2.3.2.27]"]
["ENSRNOG00000006932",96,6.175722066,366,23.62964063,0.261354887,-1.935917957,{"v":1.37839e-38,"d":"1.38E-38"},{"v":3.61783e-38,"d":"3.62E-38"},"down","yes","AABR07029272.1","protein_coding","chr10:18827239-19244808:-","gi|117553625|ref|NP_203538.2|",9396,0,"dedicator of cytokinesis protein 2 [Mus musculus]","gi|459683823|ref|NM_033374.3|",4788,0,"Mus musculus dedicator of cyto-kinesis 2 (Dock2), mRNA","Q8C3J5",3619,0,"Dedicator of cytokinesis protein 2",".",".",".",".","pfam14429","DOCK-C2","C2 domain in Dock180 and Zizimin proteins. The Dock180/Dock1 and Zizimin proteins are atypical GTP/GDP exchange factors for the small GTPases Rac and Cdc42 and are implicated cell-migration and phagocytosis. Across all Dock180 proteins, two regions are conserved: C-terminus termed CZH2 or DHR2 (or the Dedicator of cytokinesis) whereas CZH1/DHR1 contain a new family of the C2 domain.",".",".",".",".","."]
["ENSRNOG00000021724",20,1.286608764,200,12.91237193,0.099641551,-3.327108714,{"v":1.84324e-38,"d":"1.84E-38"},{"v":4.82684e-38,"d":"4.83E-38"},"down","yes","Ptprcap","protein_coding","chr1:201449113-201451288:+","gi|66730347|ref|NP_001019460.1|",705,{"v":8E-90,"d":"8.00E-90"},"protein tyrosine phosphatase receptor type C-associated protein precursor [Rattus norvegicus]","gi|298910651|emb|FQ225639.1|",851,0,"Rattus norvegicus TL0AEA4YF15 mRNA sequence","Q64697",200,{"v":9e-62,"d":"9.00E-62"},"Protein tyrosine phosphatase receptor type C-associated protein",".",".",".",".","pfam15258","FAM222A","Protein family of FAM222A. This protein family, FAM222A are a domain of unknown function. This family of proteins is found in eukaryotes and are typically between 411 and 562 amino acids in length. In humans, the gene encoding this protein domain lies in the position, chromosome 12 open reading frame 34.",".","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000008151",445,28.62704499,916,59.13866344,0.484066486,-1.046722882,{"v":1.9758E-38,"d":"1.98E-38"},{"v":5.17159e-38,"d":"5.17E-38"},"down","yes","Plscr4","protein_coding","chr8:92987381-93026049:+","gi|149018893|gb|EDL77534.1|",1251,{"v":2e-164,"d":"2.00E-164"},"rCG25065 [Rattus norvegicus]","gi|58865575|ref|NM_001012000.1|",1317,0,"Rattus norvegicus phospholipid scramblase 4 (Plscr4), mRNA","P58196",471,{"v":4E-160,"d":"4.00E-160"},"Phospholipid scramblase 4",".",".",".",".","pfam03803","Scramblase","Scramblase. Scramblase is palmitoylated and contains a potential protein kinase C phosphorylation site. Scramblase exhibits Ca2+-activated phospholipid scrambling activity in vitro. There are also possible SH3 and WW binding motifs. Scramblase is involved in the redistribution of phospholipids after cell activation or injury.","GO:0017121|phospholipid scrambling;GO:0071222|cellular response to lipopolysaccharide;","GO:0005886|plasma membrane;","GO:0017128|phospholipid scramblase activity;GO:0019899|enzyme binding;GO:0042609|CD4 receptor binding;",".","."]
["ENSRNOG00000012228",391,25.15320133,838,54.10283839,0.464914634,-1.104962256,{"v":2.13059e-38,"d":"2.13E-38"},{"v":5.56655e-38,"d":"5.57E-38"},"down","yes","Skap2","protein_coding","chr4:80950580-81100891:-","gi|18426838|ref|NP_569097.1|",1554,0,"src kinase-associated phosphoprotein 2 [Rattus norvegicus]","gi|18426837|ref|NM_130413.1|",1117,0,"Rattus norvegicus src kinase associated phosphoprotein 2 (Skap2), mRNA","Q920G0",603,0,"Src kinase-associated phosphoprotein 2",".",".",".",".","pfam00169","PH","PH domain. PH stands for pleckstrin homology.","GO:0008285|negative regulation of cell proliferation;GO:0042113|B cell activation;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;",".","K23471","SKAP2; src kinase-associated phosphoprotein 2"]
["ENSRNOG00000030012",17,1.093617449,191,12.33131519,0.088686197,-3.495146606,{"v":2.99083E-38,"d":"2.99E-38"},{"v":7.79267e-38,"d":"7.79E-38"},"down","yes","Clec4a2","protein_coding","chr4:156262692-156321392:+","gi|45758796|gb|AAS76657.1|",1177,{"v":4e-161,"d":"4.00E-161"},"dendritic cell inhibitory receptor 2 [Rattus norvegicus]","gi|45758795|gb|AY494061.1|",790,0,"Rattus norvegicus strain DA dendritic cell inhibitory receptor 2 (Dcir2) mRNA, complete cds","Q67EQ0",293,{"v":6E-98,"d":"6.00E-98"},"C-type lectin domain family 4 member A",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type",".",".","GO:0030246|carbohydrate binding;","K10057","CLEC4A, CD367; C-type lectin domain family 4 member A"]
["ENSRNOG00000001270",73,4.696121987,319,20.59523323,0.22801985,-2.132768674,{"v":3.79031E-38,"d":"3.79E-38"},{"v":9.84879e-38,"d":"9.85E-38"},"down","yes","Hvcn1","protein_coding","chr12:34335190-34370141:-","gi|564315319|ref|XP_006221413.1|",1175,{"v":7e-146,"d":"7.00E-146"},"PREDICTED: voltage-gated hydrogen channel 1 isoform X2 [Rattus norvegicus]","gi|672026745|ref|XM_006221351.2|",1882,0,"PREDICTED: Rattus norvegicus hydrogen voltage-gated channel 1 (Hvcn1), transcript variant X2, mRNA","Q3U2S8",399,{"v":3e-126,"d":"3.00E-126"},"Voltage-gated hydrogen channel 1",".",".",".",".","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0009268|response to pH;GO:0010043|response to zinc ion;GO:0032930|positive regulation of superoxide anion generation;GO:0051453|regulation of intracellular pH;GO:0071294|cellular response to zinc ion;GO:0071467|cellular response to pH;GO:1902600|proton transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;","GO:0022843|voltage-gated cation channel activity;GO:0030171|voltage-gated proton channel activity;GO:0042802|identical protein binding;","K22644","HVCN1, HV1; voltage-gated hydrogen channel 1"]
["ENSRNOG00000046683",133,8.555948279,431,27.82616151,0.307478567,-1.701442243,{"v":4.29102E-38,"d":"4.29E-38"},{"v":1.11397e-37,"d":"1.11E-37"},"down","yes","Lilrb3","protein_coding","chr1:69928945-69939048:-","gi|392337441|ref|XP_001070618.3|",4166,0,"PREDICTED: leukocyte immunoglobulin-like receptor subfamily B member 3 isoform X2 [Rattus norvegicus]","gi|672035326|ref|XM_006228230.2|",2925,0,"PREDICTED: Rattus norvegicus similar to PIRB1 (RGD1566307), transcript variant X9, mRNA","P97484",593,0,"Leukocyte immunoglobulin-like receptor subfamily B member 3",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.",".","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;",".","K06512","LILR, CD85; leukocyte immunoglobulin-like receptor"]
["ENSRNOG00000002903",165,10.6145223,486,31.37706379,0.338289216,-1.563670909,{"v":4.67695e-38,"d":"4.68E-38"},{"v":1.21141e-37,"d":"1.21E-37"},"down","yes","Specc1","protein_coding","chr10:46638809-46912802:+","gi|672067893|ref|XP_008766045.1|",5022,0,"PREDICTED: cytospin-B isoform X4 [Rattus norvegicus]","gi|672067892|ref|XM_008767823.1|",6469,0,"PREDICTED: Rattus norvegicus sperm antigen with calponin homology and coiled-coil domains 1 (Specc1), transcript variant X6, mRNA","Q5SXY1",1879,0,"Cytospin-B","SPAC15A10.08",96.7,{"v":3e-19,"d":"3.00E-19"},"COG5069","pfam00307","CH","Calponin homology (CH) domain. The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.","GO:0030036|actin cytoskeleton organization;","GO:0001650|fibrillar center;GO:0005654|nucleoplasm;GO:0005815|microtubule organizing center;GO:0005829|cytosol;GO:0031941|filamentous actin;GO:0043231|intracellular membrane-bounded organelle;",".","K23028","SPECC1; cytospin"]
["ENSRNOG00000014021",0,0.032165219,182,11.75025846,2.737405E-3,-8.51297526,{"v":5.32591e-38,"d":"5.33E-38"},{"v":1.37762e-37,"d":"1.38E-37"},"down","yes","Matn4","protein_coding","chr3:153120632-153135865:-","gi|149042955|gb|EDL96529.1|",3211,0,"matrilin 4 (predicted), isoform CRA_a [Rattus norvegicus]","gi|157818268|ref|NM_001106539.1|",2251,0,"Rattus norvegicus matrilin 4 (Matn4), mRNA","O89029",1186,0,"Matrilin-4",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0048678|response to axon injury;","GO:0062023|collagen-containing extracellular matrix;","GO:0005509|calcium ion binding;","K19467","MATN; matrilin"]
["ENSRNOG00000048917",9,0.578973944,167,10.78183056,0.053699039,-4.21895991,{"v":6.20181e-38,"d":"6.20E-38"},{"v":1.60129E-37,"d":"1.60E-37"},"down","yes","Hoxa6","protein_coding","chr4:81306407-81308850:-","gi|300797581|ref|NP_001178016.1|",1171,{"v":7e-160,"d":"7.00E-160"},"homeobox protein Hox-A6 [Rattus norvegicus]","gi|672089196|ref|XM_003752179.3|",876,0,"PREDICTED: Rattus norvegicus homeobox protein Hox-A6-like (LOC100911511), transcript variant X2, mRNA","P09092",446,{"v":8e-158,"d":"8.00E-158"},"Homeobox protein Hox-A6",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0009952|anterior/posterior pattern specification;GO:0048704|embryonic skeletal system morphogenesis;GO:0048706|embryonic skeletal system development;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0016607|nuclear speck;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837|sequence-specific double-stranded DNA binding;","K09306","HOX_6; homeobox protein HoxA/B/C6"]
["ENSRNOG00000008061",119,7.655322144,405,26.14755316,0.292773939,-1.772140954,{"v":6.68085E-38,"d":"6.68E-38"},{"v":1.72419e-37,"d":"1.72E-37"},"down","yes","Nuak1","protein_coding","chr7:19329933-19401913:+","gi|157824124|ref|NP_001100244.1|",2995,0,"NUAK family SNF1-like kinase 1 [Rattus norvegicus]","gi|157824123|ref|NM_001106774.1|",2864,0,"Rattus norvegicus NUAK family, SNF1-like kinase, 1 (Nuak1), mRNA","Q641K5",1104,0,"NUAK family SNF1-like kinase 1",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006468|protein phosphorylation;GO:0030155|regulation of cell adhesion;GO:0035507|regulation of myosin-light-chain-phosphatase activity;GO:0035556|intracellular signal transduction;GO:0042149|cellular response to glucose starvation;GO:2000772|regulation of cellular senescence;","GO:0001650|fibrillar center;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0015630|microtubule cytoskeleton;","GO:0002039|p53 binding;GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;","K08800","NUAK; NUAK family, SNF1-like kinase [EC:2.7.11.1]"]
["ENSRNOG00000003538",286,18.39850532,678,43.77294085,0.420316866,-1.250450746,{"v":7.43837e-38,"d":"7.44E-38"},{"v":1.9171E-37,"d":"1.92E-37"},"down","yes","Adamts4","protein_coding","chr13:83670183-83680065:+","gi|149040662|gb|EDL94619.1|",4090,0,"a disintegrin and metallopeptidase with thrombospondin motifs 4 [Rattus norvegicus]","gi|281306770|ref|NM_023959.1|",3309,0,"Rattus norvegicus ADAM metallopeptidase with thrombospondin type 1 motif, 4 (Adamts4), mRNA","Q8BNJ2",1497,0,"A disintegrin and metalloproteinase with thrombospondin motifs 4",".",".",".",".","pfam05986","ADAM_spacer1","ADAM-TS Spacer 1. This family represents the Spacer-1 region from the ADAM-TS family of metalloproteinases.","GO:0006508|proteolysis;GO:0030198|extracellular matrix organization;GO:0042742|defense response to bacterium;GO:0044691|tooth eruption;","GO:0005615|extracellular space;GO:0016607|nuclear speck;GO:0031012|extracellular matrix;","GO:0002020|protease binding;GO:0004222|metalloendopeptidase activity;GO:0008233|peptidase activity;GO:0008237|metallopeptidase activity;GO:0046872|metal ion binding;","K07764","ADAMTS4; a disintegrin and metalloproteinase with thrombospondin motifs 4 [EC:3.4.24.82]"]
["ENSRNOG00000065208",35,2.251565336,235,15.17203702,0.14840231,-2.752414549,{"v":8.91317e-38,"d":"8.91E-38"},{"v":2.28482e-37,"d":"2.28E-37"},"down","yes","ENSRNOG00000065208","protein_coding","chr13:85912044-85929007:-","gi|564316191|ref|XP_006221623.1|",4558,0,"PREDICTED: flocculation protein FLO11-like isoform X1 [Rattus norvegicus]","gi|672027392|ref|XM_006221562.2|",3303,0,"PREDICTED: Rattus norvegicus pyrin domain-containing protein 3-like (LOC102556096), transcript variant X2, mRNA","Q3V3Q4",430,{"v":1E-135,"d":"1.00E-135"},"Pyrin domain-containing protein 3",".",".",".",".","pfam02760","HIN","HIN-200/IF120x domain. This domain has no know function. It is found in one or two copies per protein, and is found associated with the PAAD/DAPIN domain pfam02758.",".",".",".",".","."]
["ENSRNOG00000036604",187,12.02979194,521,33.63672888,0.35763858,-1.483425722,{"v":9.11678e-38,"d":"9.12E-38"},{"v":2.33492e-37,"d":"2.33E-37"},"down","yes","Ifit2","protein_coding","chr1:232102570-232108635:+","gi|67078506|ref|NP_001019924.1|",2343,0,"interferon-induced protein with tetratricopeptide repeats 2 [Rattus norvegicus]","gi|67078505|ref|NM_001024753.1|",3402,0,"Rattus norvegicus interferon-induced protein with tetratricopeptide repeats 2 (Ifit2), mRNA","Q64112",713,0,"Interferon-induced protein with tetratricopeptide repeats 2",".",".",".",".","pfam13424","TPR_12","Tetratricopeptide repeat.","GO:0009615|response to virus;GO:0032091|negative regulation of protein binding;GO:0035457|cellular response to interferon-alpha;GO:0043065|positive regulation of apoptotic process;GO:0051607|defense response to virus;","GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;","GO:0003723|RNA binding;","K24848","IFIT2; interferon-induced protein with tetratricopeptide repeats 2"]
["ENSRNOG00000006767",38,2.444556651,242,15.62397004,0.156461939,-2.676116343,{"v":9.23578e-38,"d":"9.24E-38"},{"v":2.36434E-37,"d":"2.36E-37"},"down","yes","Cst7","protein_coding","chr3:139396850-139405557:+","gi|157820635|ref|NP_001099993.1|",711,{"v":6e-90,"d":"6.00E-90"},"cystatin-F precursor [Rattus norvegicus]","gi|157820634|ref|NM_001106523.1|",1140,0,"Rattus norvegicus cystatin F (Cst7), mRNA","O89098",244,{"v":2E-78,"d":"2.00E-78"},"Cystatin-F",".",".",".",".","pfam00031","Cystatin","Cystatin domain. Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 are related to this family but have not been included.","GO:0006955|immune response;GO:0010466|negative regulation of peptidase activity;GO:0031643|positive regulation of myelination;GO:0097340|inhibition of cysteine-type endopeptidase activity;GO:1903979|negative regulation of microglial cell activation;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0005768|endosome;GO:0005770|late endosome;GO:0005771|multivesicular body;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0031410|cytoplasmic vesicle;","GO:0004869|cysteine-type endopeptidase inhibitor activity;GO:0030414|peptidase inhibitor activity;GO:0042803|protein homodimerization activity;","K13903","CST7; cystatin-F"]
["ENSRNOG00000009636",148,9.520904851,455,29.37564614,0.324108781,-1.625449989,{"v":1.0599e-37,"d":"1.06E-37"},{"v":2.70968e-37,"d":"2.71E-37"},"down","yes","Scrn1","protein_coding","chr4:83632131-83693852:-","gi|37359832|dbj|BAC97894.1|",2311,0,"mKIAA0193 protein [Mus musculus]","gi|672049636|ref|XM_006236512.2|",4234,0,"PREDICTED: Rattus norvegicus secernin 1 (Scrn1), transcript variant X1, mRNA","Q6AY84",863,0,"Secernin-1","PA4677",187,{"v":8e-50,"d":"8.00E-50"},"COG4690","pfam03577","Peptidase_C69","Peptidase family C69.","GO:0006508|proteolysis;GO:0006887|exocytosis;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0031965|nuclear membrane;","GO:0016805|dipeptidase activity;GO:0070004|cysteine-type exopeptidase activity;","K14358","SCRN; secernin"]
["ENSRNOG00000010350",132,8.49161784,427,27.56791407,0.308025403,-1.69887876,{"v":1.11351e-37,"d":"1.11E-37"},{"v":2.84291e-37,"d":"2.84E-37"},"down","yes","Rcan2","protein_coding","chr9:16959480-17174856:-","gi|28212228|ref|NP_783168.1|",1234,{"v":6E-158,"d":"6.00E-158"},"calcipressin-2 [Rattus norvegicus]","gi|56799426|ref|NM_175578.3|",3343,0,"Rattus norvegicus regulator of calcineurin 2 (Rcan2), mRNA","Q8CH27",344,{"v":1E-108,"d":"1.00E-108"},"Calcipressin-2",".",".",".",".","pfam04847","Calcipressin","Calcipressin. Calcipressin is also known as calcineurin-binding protein, since it inhibits calcineurin-mediated transcriptional modulation by binding to calcineurin's catalytic domain.","GO:0006979|response to oxidative stress;GO:0007219|Notch signaling pathway;GO:0007614|short-term memory;GO:0019722|calcium-mediated signaling;GO:0031987|locomotion involved in locomotory behavior;GO:0033173|calcineurin-NFAT signaling cascade;GO:0050790|regulation of catalytic activity;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0003676|nucleic acid binding;GO:0008597|calcium-dependent protein serine/threonine phosphatase regulator activity;","K17903","RCAN2, ZAKI4; calcipressin-2"]
["ENSRNOG00000005053",47,3.023530595,262,16.91520723,0.178746293,-2.484014769,{"v":1.18382e-37,"d":"1.18E-37"},{"v":3.01973e-37,"d":"3.02E-37"},"down","yes","Egln3","protein_coding","chr6:71650297-71675766:-","gi|149051230|gb|EDM03403.1|",1817,0,"rCG62399 [Rattus norvegicus]","gi|9507122|ref|NM_019371.1|",2750,0,"Rattus norvegicus egl-9 family hypoxia-inducible factor 3 (Egln3), mRNA","Q91UZ4",501,{"v":8e-170,"d":"8.00E-170"},"Egl nine homolog 3","PA0310",59.7,5e-09,"COG3751","pfam13640","2OG-FeII_Oxy_3","2OG-Fe(II) oxygenase superfamily. This family contains members of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily.","GO:0001666|response to hypoxia;GO:0006915|apoptotic process;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006974|cellular response to DNA damage stimulus;GO:0018126|protein hydroxylation;GO:0018401|peptidyl-proline hydroxylation to 4-hydroxy-L-proline;GO:0042127|regulation of cell proliferation;GO:0043523|regulation of neuron apoptotic process;GO:0071456|cellular response to hypoxia;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0005506|iron ion binding;GO:0005515|protein binding;GO:0008198|ferrous iron binding;GO:0016706|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0031418|L-ascorbic acid binding;GO:0031543|peptidyl-proline dioxygenase activity;GO:0031545|peptidyl-proline 4-dioxygenase activity;","K09592","EGLN, HPH; hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29]"]
["ENSRNOG00000002930",143,9.19925266,446,28.79458941,0.319478515,-1.646209182,{"v":1.22943E-37,"d":"1.23E-37"},{"v":3.13326e-37,"d":"3.13E-37"},"down","yes","Ppl","protein_coding","chr10:10450919-10496575:+","gi|157818431|ref|NP_001100446.1|",7889,0,"periplakin [Rattus norvegicus]","gi|157818430|ref|NM_001106976.1|",6281,0,"Rattus norvegicus periplakin (Ppl), mRNA","Q9R269",2893,0,"Periplakin",".",".",".",".","pfam10174","Cast","RIM-binding protein of the cytomatrix active zone. This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.","GO:0009612|response to mechanical stimulus;GO:0042060|wound healing;GO:0045104|intermediate filament cytoskeleton organization;","GO:0005737|cytoplasm;GO:0005882|intermediate filament;GO:0005886|plasma membrane;GO:0016020|membrane;","GO:0005198|structural molecule activity;","K10386","PPL; periplakin"]
["ENSRNOG00000064399",138,8.87760047,437,28.21353267,0.314657529,-1.668145632,{"v":1.39328E-37,"d":"1.39E-37"},{"v":3.54753E-37,"d":"3.55E-37"},"down","yes","ENSRNOG00000064399","protein_coding","chr8:41950987-41961199:+","gi|149041405|gb|EDL95246.1|",440,{"v":1E-46,"d":"1.00E-46"},"rCG57917 [Rattus norvegicus]","gi|313482846|ref|NR_037614.1|",2104,0,"Rattus norvegicus ischemia related factor vof-16 (Vof16), long non-coding RNA",".",".",".",".",".",".",".",".","pfam11279","DUF3080","Protein of unknown function (DUF3080). Some members in this family of proteins are annotated as lipoproteins however this cannot be confirmed. Currently this family has no known function.",".",".",".",".","."]
["ENSRNOG00000010296",454,29.20601894,922,59.5260346,0.490642777,-1.027255072,{"v":1.49961e-37,"d":"1.50E-37"},{"v":3.81333e-37,"d":"3.81E-37"},"down","yes","Slc7a7","protein_coding","chr15:27822091-27865648:-","gi|13786176|ref|NP_112631.1|",2480,0,"Y+L amino acid transporter 1 [Rattus norvegicus]","gi|13786175|ref|NM_031341.1|",2054,0,"Rattus norvegicus solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 (Slc7a7), mRNA","Q9R0S5",959,0,"Y+L amino acid transporter 1","BS_ykbA",159,{"v":2E-41,"d":"2.00E-41"},"COG0531","pfam13520","AA_permease_2","Amino acid permease.","GO:0000821|regulation of arginine metabolic process;GO:0003333|amino acid transmembrane transport;GO:0008150|biological_process;GO:0015807|L-amino acid transport;GO:1902475|L-alpha-amino acid transmembrane transport;GO:1990822|basic amino acid transmembrane transport;","GO:0005575|cellular_component;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;","GO:0003674|molecular_function;GO:0015174|basic amino acid transmembrane transporter activity;GO:0015179|L-amino acid transmembrane transporter activity;","K13867","SLC7A7; solute carrier family 7 (L-type amino acid transporter), member 7"]
["ENSRNOG00000013309",464,29.84932332,936,60.42990064,0.493949568,-1.017564344,{"v":1.56626E-37,"d":"1.57E-37"},{"v":3.9803e-37,"d":"3.98E-37"},"down","yes","Pik3ap1","protein_coding","chr1:240093065-240204828:-","gi|672040398|ref|XP_008758636.1|",4112,0,"PREDICTED: phosphoinositide 3-kinase adapter protein 1 isoform X1 [Rattus norvegicus]","gi|672040397|ref|XM_008760414.1|",2492,0,"PREDICTED: Rattus norvegicus phosphoinositide-3-kinase adaptor protein 1 (Pik3ap1), transcript variant X1, mRNA","Q9EQ32",1446,0,"Phosphoinositide 3-kinase adapter protein 1",".",".",".",".","pfam14545","DBB","Dof, BCAP, and BANK (DBB) motif,. The DBB domain is named from the Drosophila (Downstream of FGFR - Dof, also known as Heartbroken or Stumps) protein, the BANKS and BCAP, both signalling in B-cell pathway, proteins. This domain defines a minimal region required for mediating Dof dimerization. Since this domain can interact both with itself and with a region in the C-terminal part of the molecule, it may mediate either intermolecular or intramolecular interactions. Mutants lacking this domain disrupt FGFR signal transduction and fibroblast growth-factor signalling.","GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0016310|phosphorylation;GO:0034122|negative regulation of toll-like receptor signaling pathway;GO:0034123|positive regulation of toll-like receptor signaling pathway;GO:0034134|toll-like receptor 2 signaling pathway;GO:0034142|toll-like receptor 4 signaling pathway;GO:0034154|toll-like receptor 7 signaling pathway;GO:0034162|toll-like receptor 9 signaling pathway;GO:0050727|regulation of inflammatory response;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016020|membrane;","GO:0003953|NAD+ nucleosidase activity;GO:0005102|signaling receptor binding;GO:0016301|kinase activity;GO:0036312|phosphatidylinositol 3-kinase regulatory subunit binding;GO:0042802|identical protein binding;","K12230","PIK3AP1, BCAP; phosphoinositide 3-kinase adapter protein 1"]
["ENSRNOG00000017912",165,10.6145223,483,31.18337821,0.340390391,-1.554737784,{"v":1.56667e-37,"d":"1.57E-37"},{"v":3.9803e-37,"d":"3.98E-37"},"down","yes","Atp2a3","protein_coding","chr10:57582128-57612748:+","gi|149053310|gb|EDM05127.1|",4897,0,"ATPase, Ca++ transporting, ubiquitous, isoform CRA_b [Rattus norvegicus]","gi|672067716|ref|XM_006246597.2|",4224,0,"PREDICTED: Rattus norvegicus ATPase, Ca++ transporting, ubiquitous (Atp2a3), transcript variant X1, mRNA","P18596",1868,0,"Sarcoplasmic/endoplasmic reticulum calcium ATPase 3","BH2515",518,{"v":7e-157,"d":"7.00E-157"},"COG0474","pfam00122","E1-E2_ATPase","E1-E2 ATPase.","GO:0006874|cellular calcium ion homeostasis;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0032469|endoplasmic reticulum calcium ion homeostasis;GO:0034220|ion transmembrane transport;GO:0070059|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0070588|calcium ion transmembrane transport;GO:0097421|liver regeneration;GO:1900121|negative regulation of receptor binding;GO:1903515|calcium ion transport from cytosol to endoplasmic reticulum;","GO:0005575|cellular_component;GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;GO:0016529|sarcoplasmic reticulum;GO:0031090|organelle membrane;GO:0033017|sarcoplasmic reticulum membrane;","GO:0003674|molecular_function;GO:0005388|calcium-transporting ATPase activity;GO:0005509|calcium ion binding;GO:0005524|ATP binding;GO:0008656|cysteine-type endopeptidase activator activity involved in apoptotic process;GO:0015085|calcium ion transmembrane transporter activity;GO:0015662|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism;GO:0030899|calcium-dependent ATPase activity;GO:0044325|ion channel binding;GO:0046872|metal ion binding;","K05853","ATP2A; P-type Ca2+ transporter type 2A [EC:7.2.2.10]"]
["ENSRNOG00000008365",51,3.280852347,270,17.43170211,0.188211818,-2.409570874,{"v":1.78513E-37,"d":"1.79E-37"},{"v":4.53333e-37,"d":"4.53E-37"},"down","yes","ENSRNOG00000008365","protein_coding","chr10:81318026-81320192:+","gi|293340385|ref|XP_002724587.1|",1179,{"v":3e-156,"d":"3.00E-156"},"PREDICTED: homeobox protein Hox-B2 [Rattus norvegicus]","gi|672069230|ref|XM_002727806.4|",1424,0,"PREDICTED: Rattus norvegicus homeobox B2 (Hoxb2), mRNA","P0C1T1",416,{"v":3e-141,"d":"3.00E-141"},"Homeobox protein Hox-B2",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0002011|morphogenesis of an epithelial sheet;GO:0006357|regulation of transcription by RNA polymerase II;GO:0009952|anterior/posterior pattern specification;GO:0009953|dorsal/ventral pattern formation;GO:0021569|rhombomere 3 development;GO:0021570|rhombomere 4 development;GO:0021612|facial nerve structural organization;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048704|embryonic skeletal system morphogenesis;GO:0048705|skeletal system morphogenesis;GO:0048857|neural nucleus development;","GO:0005634|nucleus;GO:0005654|nucleoplasm;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09302","HOX_2; homeobox protein HoxA/B2"]
["ENSRNOG00000013572",158,10.16420923,470,30.34407404,0.334965213,-1.577916818,{"v":2.50761e-37,"d":"2.51E-37"},{"v":6.35392e-37,"d":"6.35E-37"},"down","yes","Lxn","protein_coding","chr2:151727102-151733460:-","gi|14269568|ref|NP_113843.1|",1211,{"v":3E-162,"d":"3.00E-162"},"latexin [Rattus norvegicus]","gi|298888579|emb|FQ220594.1|",1088,0,"Rattus norvegicus TL0ADA42YF08 mRNA sequence","Q64361",471,{"v":9e-164,"d":"9.00E-164"},"Latexin",".",".",".",".","pfam06907","Latexin","Latexin. This family consists of several animal specific latexin proteins. Latexin is a carboxypeptidase A inhibitor and is expressed in a cell type-specific manner in both central and peripheral nervous systems in the rat.","GO:0006954|inflammatory response;GO:0010951|negative regulation of endopeptidase activity;GO:0050965|detection of temperature stimulus involved in sensory perception of pain;","GO:0005615|extracellular space;GO:0005737|cytoplasm;","GO:0008191|metalloendopeptidase inhibitor activity;GO:0008201|heparin binding;","K23594","LXN; latexin"]
["ENSRNOG00000016818",144,9.263583099,445,28.73002755,0.32243558,-1.632917144,{"v":3.83541e-37,"d":"3.84E-37"},{"v":9.684e-37,"d":"9.68E-37"},"down","yes","Fgfr3","protein_coding","chr14:76987993-77003341:-","gi|564384650|ref|XP_006251454.1|",3915,0,"PREDICTED: fibroblast growth factor receptor 3 isoform X3 [Rattus norvegicus]","gi|672076986|ref|XM_006251392.2|",3477,0,"PREDICTED: Rattus norvegicus fibroblast growth factor receptor 3 (Fgfr3), transcript variant X2, mRNA","Q61851",1394,0,"Fibroblast growth factor receptor 3",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001938|positive regulation of endothelial cell proliferation;GO:0002009|morphogenesis of an epithelium;GO:0002089|lens morphogenesis in camera-type eye;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007267|cell-cell signaling;GO:0007275|multicellular organism development;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0008543|fibroblast growth factor receptor signaling pathway;GO:0010518|positive regulation of phospholipase activity;GO:0010629|negative regulation of gene expression;GO:0010712|regulation of collagen metabolic process;GO:0014003|oligodendrocyte development;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0021762|substantia nigra development;GO:0022010|central nervous system myelination;GO:0030154|cell differentiation;GO:0030278|regulation of ossification;GO:0030282|bone mineralization;GO:0030501|positive regulation of bone mineralization;GO:0030900|forebrain development;GO:0031398|positive regulation of protein ubiquitination;GO:0033674|positive regulation of kinase activity;GO:0035019|somatic stem cell population maintenance;GO:0036342|post-anal tail morphogenesis;GO:0038066|p38MAPK cascade;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0043410|positive regulation of MAPK cascade;GO:0043525|positive regulation of neuron apoptotic process;GO:0043552|positive regulation of phosphatidylinositol 3-kinase activity;GO:0045596|negative regulation of cell differentiation;GO:0045670|regulation of osteoclast differentiation;GO:0045839|negative regulation of mitotic nuclear division;GO:0045879|negative regulation of smoothened signaling pathway;GO:0046777|protein autophosphorylation;GO:0046850|regulation of bone remodeling;GO:0048546|digestive tract morphogenesis;GO:0048640|negative regulation of developmental growth;GO:0048678|response to axon injury;GO:0048712|negative regulation of astrocyte differentiation;GO:0048839|inner ear development;GO:0050680|negative regulation of epithelial cell proliferation;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0051216|cartilage development;GO:0060113|inner ear receptor cell differentiation;GO:0060348|bone development;GO:0060349|bone morphogenesis;GO:0060385|axonogenesis involved in innervation;GO:0061144|alveolar secondary septum development;GO:0061430|bone trabecula morphogenesis;GO:0070307|lens fiber cell development;GO:0070371|ERK1 and ERK2 cascade;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070977|bone maturation;GO:0071864|positive regulation of cell proliferation in bone marrow;GO:0072148|epithelial cell fate commitment;GO:0090080|positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway;GO:0090102|cochlea development;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:1902178|fibroblast growth factor receptor apoptotic signaling pathway;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009898|cytoplasmic side of plasma membrane;GO:0009986|cell surface;GO:0030133|transport vesicle;GO:0043235|receptor complex;GO:0048471|perinuclear region of cytoplasm;","GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0005007|fibroblast growth factor-activated receptor activity;GO:0005524|ATP binding;GO:0008083|growth factor activity;GO:0017134|fibroblast growth factor binding;GO:0042802|identical protein binding;","K05094","FGFR3, CD333; fibroblast growth factor receptor 3 [EC:2.7.10.1]"]
["ENSRNOG00000008336",265,17.04756612,641,41.38415204,0.411934648,-1.279512617,{"v":3.94054e-37,"d":"3.94E-37"},{"v":9.94505e-37,"d":"9.95E-37"},"down","yes","Tnfrsf11b","protein_coding","chr7:85566520-85594538:-","gi|6981306|ref|NP_037002.1|",2094,0,"tumor necrosis factor receptor superfamily member 11B precursor [Rattus norvegicus]","gi|52138596|ref|NM_012870.2|",2106,0,"Rattus norvegicus tumor necrosis factor receptor superfamily, member 11b (Tnfrsf11b), mRNA","O08727",811,0,"Tumor necrosis factor receptor superfamily member 11B",".",".",".",".","pfam00531","Death","Death domain.","GO:0006915|apoptotic process;GO:0007165|signal transduction;GO:0007584|response to nutrient;GO:0009410|response to xenobiotic stimulus;GO:0010035|response to inorganic substance;GO:0030198|extracellular matrix organization;GO:0032026|response to magnesium ion;GO:0042489|negative regulation of odontogenesis of dentin-containing tooth;GO:0043627|response to estrogen;GO:0045779|negative regulation of bone resorption;GO:0046685|response to arsenic-containing substance;","GO:0005615|extracellular space;GO:0031012|extracellular matrix;","GO:0003674|molecular_function;GO:0005125|cytokine activity;","K05148","TNFRSF11B, OPG; tumor necrosis factor receptor superfamily member 11B"]
["ENSRNOG00000002657",102,6.561704695,369,23.82332621,0.275431929,-1.860232283,{"v":5.94927e-37,"d":"5.95E-37"},{"v":1.49618e-36,"d":"1.50E-36"},"down","yes","Pla2g4a","protein_coding","chr13:61877813-62022266:-","gi|126722674|ref|NP_598235.2|",3930,0,"cytosolic phospholipase A2 [Rattus norvegicus]","gi|126722673|ref|NM_133551.2|",2812,0,"Rattus norvegicus phospholipase A2 group IVA (Pla2g4a), mRNA","P50393",1493,0,"Cytosolic phospholipase A2",".",".",".",".","pfam01735","PLA2_B","Lysophospholipase catalytic domain. This family consists of Lysophospholipase / phospholipase B EC:3.1.1.5 and cytosolic phospholipase A2 EC:3.1.4 which also has a C2 domain pfam00168. Phospholipase B enzymes catalyse the release of fatty acids from lysophsopholipids and are capable in vitro of hydrolysing all phospholipids extractable form yeast cells. Cytosolic phospholipase A2 associates with natural membranes in response to physiological increases in Ca2+ and selectively hydrolyses arachidonyl phospholipids, the aligned region corresponds the the carboxy-terminal Ca2+-independent catalytic domain of the protein as discussed in.","GO:0001516|prostaglandin biosynthetic process;GO:0001542|ovulation from ovarian follicle;GO:0001554|luteolysis;GO:0002827|positive regulation of T-helper 1 type immune response;GO:0006071|glycerol metabolic process;GO:0006640|monoacylglycerol biosynthetic process;GO:0006663|platelet activating factor biosynthetic process;GO:0007568|aging;GO:0008284|positive regulation of cell proliferation;GO:0009408|response to heat;GO:0009725|response to hormone;GO:0010033|response to organic substance;GO:0010226|response to lithium ion;GO:0010243|response to organonitrogen compound;GO:0010572|positive regulation of platelet activation;GO:0019369|arachidonic acid metabolic process;GO:0019370|leukotriene biosynthetic process;GO:0030501|positive regulation of bone mineralization;GO:0031340|positive regulation of vesicle fusion;GO:0031394|positive regulation of prostaglandin biosynthetic process;GO:0031622|positive regulation of fever generation;GO:0032308|positive regulation of prostaglandin secretion;GO:0032496|response to lipopolysaccharide;GO:0033280|response to vitamin D;GO:0034478|phosphatidylglycerol catabolic process;GO:0034638|phosphatidylcholine catabolic process;GO:0036151|phosphatidylcholine acyl-chain remodeling;GO:0042127|regulation of cell proliferation;GO:0042542|response to hydrogen peroxide;GO:0043032|positive regulation of macrophage activation;GO:0043065|positive regulation of apoptotic process;GO:0043129|surfactant homeostasis;GO:0046456|icosanoid biosynthetic process;GO:0046475|glycerophospholipid catabolic process;GO:0046697|decidualization;GO:0050482|arachidonic acid secretion;GO:0050729|positive regulation of inflammatory response;GO:0051384|response to glucocorticoid;GO:0051592|response to calcium ion;GO:0051597|response to methylmercury;GO:0071236|cellular response to antibiotic;","GO:0000139|Golgi membrane;GO:0005634|nucleus;GO:0005635|nuclear envelope;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0042588|zymogen granule;GO:0043231|intracellular membrane-bounded organelle;GO:0048471|perinuclear region of cytoplasm;","GO:0004622|lysophospholipase activity;GO:0004623|phospholipase A2 activity;GO:0005509|calcium ion binding;GO:0005544|calcium-dependent phospholipid binding;GO:0008374|O-acyltransferase activity;GO:0010314|phosphatidylinositol-5-phosphate binding;GO:0032266|phosphatidylinositol-3-phosphate binding;GO:0035035|histone acetyltransferase binding;GO:0047498|calcium-dependent phospholipase A2 activity;GO:0047499|calcium-independent phospholipase A2 activity;GO:0070273|phosphatidylinositol-4-phosphate binding;GO:0102545|phosphatidyl phospholipase B activity;GO:1902387|ceramide 1-phosphate binding;","K16342","PLA2G4, CPLA2; cytosolic phospholipase A2 [EC:3.1.1.4]"]
["ENSRNOG00000018952",244,15.69662692,607,39.18904881,0.400536053,-1.319995988,{"v":6.54093e-37,"d":"6.54E-37"},{"v":1.64064e-36,"d":"1.64E-36"},"down","yes","Sema3g","protein_coding","chr16:6413589-6425221:+","gi|281182586|ref|NP_001094352.1|",4003,0,"semaphorin-3G precursor [Rattus norvegicus]","gi|281182585|ref|NM_001100882.1|",3626,0,"Rattus norvegicus semaphorin 3G (Sema3g), mRNA","Q4LFA9",1452,0,"Semaphorin-3G",".",".",".",".","pfam01403","Sema","Sema domain. The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and human plexin A-3.","GO:0001755|neural crest cell migration;GO:0007411|axon guidance;GO:0030335|positive regulation of cell migration;GO:0030517|negative regulation of axon extension;GO:0048843|negative regulation of axon extension involved in axon guidance;GO:0050919|negative chemotaxis;GO:0071526|semaphorin-plexin signaling pathway;","GO:0005615|extracellular space;GO:0005887|integral component of plasma membrane;","GO:0005102|signaling receptor binding;GO:0030215|semaphorin receptor binding;GO:0045499|chemorepellent activity;","K06840","SEMA3; semaphorin 3"]
["ENSRNOG00000006963",56,3.602504538,278,17.94819698,0.200716793,-2.31676677,{"v":7.2619e-37,"d":"7.26E-37"},{"v":1.81908E-36,"d":"1.82E-36"},"down","yes","Ctse","protein_coding","chr13:43092128-43114502:+","gi|564380459|ref|XP_006249810.1|",2063,0,"PREDICTED: cathepsin E isoform X1 [Rattus norvegicus]","gi|672073643|ref|XM_006249748.2|",1940,0,"PREDICTED: Rattus norvegicus cathepsin E (Ctse), transcript variant X1, mRNA","P16228",798,0,"Cathepsin E",".",".",".",".","pfam00026","Asp","Eukaryotic aspartyl protease. Aspartyl (acid) proteases include pepsins, cathepsins, and renins. Two-domain structure, probably arising from ancestral duplication. This family does not include the retroviral nor retrotransposon proteases (pfam00077), which are much smaller and appear to be homologous to a single domain of the eukaryotic asp proteases.","GO:0006508|proteolysis;GO:0016540|protein autoprocessing;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;","GO:0005768|endosome;","GO:0004190|aspartic-type endopeptidase activity;GO:0008233|peptidase activity;GO:0042802|identical protein binding;","K01382","CTSE; cathepsin E [EC:3.4.23.34]"]
["ENSRNOG00000003105",9,0.578973944,162,10.45902126,0.055356417,-4.175105621,{"v":1.19253E-36,"d":"1.19E-36"},{"v":2.97159e-36,"d":"2.97E-36"},"down","yes","Kif19","protein_coding","chr10:99799400-99826546:+","gi|403310676|ref|NP_001258131.1|",4872,0,"kinesin-like protein KIF19 [Rattus norvegicus]","gi|156616321|ref|NM_001102615.1|",2799,0,"Mus musculus kinesin family member 19A (Kif19a), mRNA","Q99PT9",1881,0,"Kinesin-like protein KIF19",".",".",".",".","pfam00225","Kinesin","Kinesin motor domain.","GO:0007018|microtubule-based movement;GO:0060404|axonemal microtubule depolymerization;GO:0070462|plus-end specific microtubule depolymerization;","GO:0005871|kinesin complex;GO:0005874|microtubule;GO:0005929|cilium;GO:0005930|axoneme;","GO:0003777|microtubule motor activity;GO:0005524|ATP binding;GO:0008017|microtubule binding;GO:0008574|ATP-dependent microtubule motor activity, plus-end-directed;GO:0016887|ATPase activity;","K10401","KIF18_19; kinesin family member 18/19"]
["ENSRNOG00000004626",2,0.128660876,148,9.555155229,0.013465074,-6.214633985,{"v":1.36688e-36,"d":"1.37E-36"},{"v":3.40159e-36,"d":"3.40E-36"},"down","yes","Slc34a2","protein_coding","chr14:57910480-57930436:-","gi|564383841|ref|XP_006251094.1|",2962,0,"PREDICTED: sodium-dependent phosphate transport protein 2B isoform X1 [Rattus norvegicus]","gi|672076344|ref|XM_006251032.2|",3916,0,"PREDICTED: Rattus norvegicus solute carrier family 34 (type II sodium/phosphate contransporter), member 2 (Slc34a2), transcript variant X1, mRNA","Q9JJ09",1142,0,"Sodium-dependent phosphate transport protein 2B","VC0676",87.4,{"v":1e-16,"d":"1.00E-16"},"COG1283","pfam02690","Na_Pi_cotrans","Na+/Pi-cotransporter. This is a family of mainly mammalian type II renal Na+/Pi-cotransporters with other related sequences from lower eukaryotes and bacteria some of which are also Na+/Pi-cotransporters. In the kidney the type II renal Na+/Pi-cotransporters protein allows re-absorption of filtered Pi in the proximal tubule.","GO:0001701|in utero embryonic development;GO:0006817|phosphate ion transport;GO:0007568|aging;GO:0009750|response to fructose;GO:0030643|cellular phosphate ion homeostasis;GO:0032355|response to estradiol;GO:0035725|sodium ion transmembrane transport;GO:0043627|response to estrogen;GO:0044341|sodium-dependent phosphate transport;","GO:0005903|brush border;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0031526|brush border membrane;GO:0031528|microvillus membrane;GO:0031982|vesicle;","GO:0005436|sodium:phosphate symporter activity;GO:0019904|protein domain specific binding;GO:0031402|sodium ion binding;GO:0042301|phosphate ion binding;","K14683","SLC34A, NPT, nptA; solute carrier family 34 (sodium-dependent phosphate cotransporter)"]
["ENSRNOG00000004743",1,0.064330438,155,10.00708825,0.006428487,-7.281305025,{"v":2.32955e-36,"d":"2.33E-36"},{"v":5.77715e-36,"d":"5.78E-36"},"down","yes","Cdcp1","protein_coding","chr8:122828685-122865388:-","gi|564366541|ref|XP_006244251.1|",4052,0,"PREDICTED: CUB domain-containing protein 1 isoform X1 [Rattus norvegicus]","gi|672063796|ref|XM_006244189.2|",5223,0,"PREDICTED: Rattus norvegicus CUB domain containing protein 1 (Cdcp1), transcript variant X1, mRNA","Q5U462",1427,0,"CUB domain-containing protein 1",".",".",".",".","pfam00431","CUB","CUB domain.",".","GO:0016021|integral component of membrane;",".","K06732","CDCP1, CD318; CUB domain-containing protein 1"]
["ENSRNOG00000042905",92,5.918400313,347,22.4029653,0.264179328,-1.920410516,{"v":2.66493E-36,"d":"2.66E-36"},{"v":6.59742e-36,"d":"6.60E-36"},"down","yes","RT1-T24-4","protein_coding","chr20:2684515-2692511:+","gi|77404170|ref|NP_001008826.2|",1830,0,"RT1 class I, locus T24, gene 4 [Rattus norvegicus]","gi|261862313|ref|NM_001008826.3|",1650,0,"Rattus norvegicus RT1 class I, locus T24, gene 4 (RT1-T24-4), mRNA","P16391",383,{"v":5e-127,"d":"5.00E-127"},"RT1 class I histocompatibility antigen, AA alpha chain",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.","GO:0001916|positive regulation of T cell mediated cytotoxicity;GO:0002476|antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002486|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0006955|immune response;","GO:0005615|extracellular space;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0005102|signaling receptor binding;GO:0042605|peptide antigen binding;","K06751","MHC1; MHC class I antigen"]
["ENSRNOG00000015430",241,15.5036356,598,38.60799207,0.401565447,-1.316292957,{"v":3.07262e-36,"d":"3.07E-36"},{"v":7.60013e-36,"d":"7.60E-36"},"down","yes","Nlgn2","protein_coding","chr10:54544588-54558434:-","gi|50510903|dbj|BAD32437.1|",3470,0,"mKIAA1366 protein [Mus musculus]","gi|755538172|ref|XM_006532902.2|",3532,0,"PREDICTED: Mus musculus neuroligin 2 (Nlgn2), transcript variant X2, mRNA","Q62888",1312,0,"Neuroligin-2","BS_pnbA",214,{"v":2e-58,"d":"2.00E-58"},"COG2272","pfam00135","COesterase","Carboxylesterase family.","GO:0001966|thigmotaxis;GO:0002087|regulation of respiratory gaseous exchange by neurological system process;GO:0007155|cell adhesion;GO:0007158|neuron cell-cell adhesion;GO:0007268|chemical synaptic transmission;GO:0007416|synapse assembly;GO:0007420|brain development;GO:0007630|jump response;GO:0008284|positive regulation of cell proliferation;GO:0019233|sensory perception of pain;GO:0032024|positive regulation of insulin secretion;GO:0032230|positive regulation of synaptic transmission, GABAergic;GO:0035176|social behavior;GO:0035418|protein localization to synapse;GO:0035641|locomotory exploration behavior;GO:0048488|synaptic vesicle endocytosis;GO:0050804|modulation of chemical synaptic transmission;GO:0050808|synapse organization;GO:0050885|neuromuscular process controlling balance;GO:0051965|positive regulation of synapse assembly;GO:0051968|positive regulation of synaptic transmission, glutamatergic;GO:0060999|positive regulation of dendritic spine development;GO:0072553|terminal button organization;GO:0097104|postsynaptic membrane assembly;GO:0097105|presynaptic membrane assembly;GO:0097116|gephyrin clustering involved in postsynaptic density assembly;GO:0097119|postsynaptic density protein 95 clustering;GO:0097151|positive regulation of inhibitory postsynaptic potential;GO:0098698|postsynaptic specialization assembly;GO:1901142|insulin metabolic process;GO:1902474|positive regulation of protein localization to synapse;GO:1904034|positive regulation of t-SNARE clustering;GO:1904862|inhibitory synapse assembly;GO:1905606|regulation of presynapse assembly;GO:2000311|regulation of AMPA receptor activity;GO:2000463|positive regulation of excitatory postsynaptic potential;GO:2000809|positive regulation of synaptic vesicle clustering;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0042734|presynaptic membrane;GO:0043198|dendritic shaft;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0060076|excitatory synapse;GO:0060077|inhibitory synapse;GO:0097470|ribbon synapse;GO:0098690|glycinergic synapse;GO:0098691|dopaminergic synapse;GO:0098982|GABA-ergic synapse;GO:0099055|integral component of postsynaptic membrane;GO:0099060|integral component of postsynaptic specialization membrane;","GO:0005515|protein binding;GO:0038023|signaling receptor activity;GO:0042043|neurexin family protein binding;GO:0042802|identical protein binding;GO:0050839|cell adhesion molecule binding;","K07378","NLGN; neuroligin"]
["ENSRNOG00000063505",228,14.66733991,577,37.25219302,0.393730911,-1.344718114,{"v":3.85918e-36,"d":"3.86E-36"},{"v":9.51682e-36,"d":"9.52E-36"},"down","yes","Scn2b","protein_coding","chr8:45425629-45437765:+","gi|472391630|ref|XP_004415103.1|",940,{"v":5e-113,"d":"5.00E-113"},"PREDICTED: sodium channel subunit beta-2 [Odobenus rosmarus divergens]","gi|672061598|ref|XM_006242895.2|",4199,0,"PREDICTED: Rattus norvegicus sodium channel, voltage-gated, type II, beta subunit (Scn2b), transcript variant X1, mRNA","P54900",362,{"v":1e-113,"d":"1.00E-113"},"Sodium channel subunit beta-2",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000028404",7,0.450313067,154,9.942526387,0.045291614,-4.464612238,{"v":4.58923E-36,"d":"4.59E-36"},{"v":1.1283E-35,"d":"1.13E-35"},"down","yes","Ppp1r1b","protein_coding","chr10:83347731-83356775:+","gi|61889054|ref|NP_612530.1|",781,{"v":4e-97,"d":"4.00E-97"},"protein phosphatase 1 regulatory subunit 1B [Rattus norvegicus]","gi|61889053|ref|NM_138521.1|",1739,0,"Rattus norvegicus protein phosphatase 1, regulatory (inhibitor) subunit 1B (Ppp1r1b), mRNA","Q6J4I0",305,{"v":1e-98,"d":"1.00E-98"},"Protein phosphatase 1 regulatory subunit 1B",".",".",".",".","pfam05395","DARPP-32","Protein phosphatase inhibitor 1/DARPP-32. This family consists of several mammalian protein phosphatase inhibitor 1 (IPP-1) and dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32) proteins. Protein phosphatase inhibitor-1 is involved in signal transduction and is an endogenous inhibitor of protein phosphatase-1. It has been demonstrated that DARPP-32, if phosphorylated, can inhibit protein-phosphatase-1. DARPP-32 has a key role in many neurotransmitter pathways throughout the brain and has been shown to be involved in controlling receptors, ion channels and other physiological factors including the brain's response to drugs of abuse, such as cocaine, opiates and nicotine. DARPP-32 is reciprocally regulated by the two neurotransmitters that are most often implicated in schizophrenia - dopamine and glutamate. Dopamine activates DARPP-32 through the D1 receptor pathway and disables DARPP-32 through the D2 receptor. Glutamate, acting through the N-methyl-d-aspartate receptor, renders DARPP-32 inactive. A mutant form of DARPP-32 has been linked with gastric cancers.","GO:0001975|response to amphetamine;GO:0006351|transcription, DNA-templated;GO:0007613|memory;GO:0007621|negative regulation of female receptivity;GO:0007626|locomotory behavior;GO:0008542|visual learning;GO:0032515|negative regulation of phosphoprotein phosphatase activity;GO:0035094|response to nicotine;GO:0035556|intracellular signal transduction;GO:0042220|response to cocaine;GO:0043278|response to morphine;GO:0043987|histone H3-S10 phosphorylation;GO:0048148|behavioral response to cocaine;GO:0071314|cellular response to cocaine;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0043025|neuronal cell body;GO:0044326|dendritic spine neck;GO:0044327|dendritic spine head;GO:0098794|postsynapse;GO:0098978|glutamatergic synapse;","GO:0004864|protein phosphatase inhibitor activity;GO:0031748|D1 dopamine receptor binding;GO:0031749|D2 dopamine receptor binding;GO:0031750|D3 dopamine receptor binding;GO:0031751|D4 dopamine receptor binding;GO:0031752|D5 dopamine receptor binding;","K15494","PPP1R1B, DARPP32; protein phosphatase 1 regulatory subunit 1B"]
["ENSRNOG00000048636",25,1.608260955,203,13.10605751,0.122711269,-3.026660347,{"v":5.74024e-36,"d":"5.74E-36"},{"v":1.40887e-35,"d":"1.41E-35"},"down","yes","Il2rb","protein_coding","chr7:110033341-110048054:-","gi|564360935|ref|XP_006242032.1|",2407,0,"PREDICTED: interleukin-2 receptor subunit beta isoform X1 [Rattus norvegicus]","gi|672059844|ref|XM_006241970.2|",2553,0,"PREDICTED: Rattus norvegicus interleukin 2 receptor, beta (Il2rb), transcript variant X1, mRNA","P26896",894,0,"Interleukin-2 receptor subunit beta",".",".",".",".","pfam00041","fn3","Fibronectin type III domain.","GO:0019221|cytokine-mediated signaling pathway;GO:0030101|natural killer cell activation;GO:0035723|interleukin-15-mediated signaling pathway;GO:0038110|interleukin-2-mediated signaling pathway;GO:0043066|negative regulation of apoptotic process;GO:0050766|positive regulation of phagocytosis;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0004896|cytokine receptor activity;GO:0004911|interleukin-2 receptor activity;GO:0019976|interleukin-2 binding;GO:0042010|interleukin-15 receptor activity;","K05069","IL2RB, CD122; interleukin 2 receptor beta"]
["ENSRNOG00000005705",39,2.508887089,236,15.23659888,0.164661885,-2.60242145,{"v":8.10152E-36,"d":"8.10E-36"},{"v":1.98245E-35,"d":"1.98E-35"},"down","yes","Qpct","protein_coding","chr6:15964657-15996711:-","gi|564354650|ref|XP_006239694.1|",1784,0,"PREDICTED: glutaminyl-peptide cyclotransferase isoform X1 [Rattus norvegicus]","gi|672055160|ref|XM_006239632.2|",1552,0,"PREDICTED: Rattus norvegicus similar to Glutaminyl-peptide cyclotransferase precursor (QC) (RGD1562284), transcript variant X1, mRNA","Q9CYK2",654,0,"Glutaminyl-peptide cyclotransferase",".",".",".",".","pfam04389","Peptidase_M28","Peptidase family M28.","GO:0006508|proteolysis;GO:0017186|peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase;",".","GO:0008235|metalloexopeptidase activity;GO:0008270|zinc ion binding;GO:0016603|glutaminyl-peptide cyclotransferase activity;","K00683","QPCT; glutaminyl-peptide cyclotransferase [EC:2.3.2.5]"]
["ENSRNOG00000019319",346,22.25833161,752,48.55051846,0.458457135,-1.125141243,{"v":1.31127e-35,"d":"1.31E-35"},{"v":3.19501e-35,"d":"3.20E-35"},"down","yes","Fchsd2","protein_coding","chr1:155444460-155685539:+","gi|672037846|ref|XP_008757943.1|",3755,0,"PREDICTED: FCH and double SH3 domains protein 2 isoform X2 [Rattus norvegicus]","gi|672037845|ref|XM_008759721.1|",4305,0,"PREDICTED: Rattus norvegicus FCH and double SH3 domains 2 (Fchsd2), transcript variant X2, mRNA","Q3USJ8",1375,0,"F-BAR and double SH3 domains protein 2",".",".",".",".","pfam00611","FCH","Fes/CIP4, and EFC/F-BAR homology domain. Alignment extended from. Highly alpha-helical. The cytosolic endocytic adaptor proteins in fungi carry this domain at the N-terminus; several of these have been referred to as muniscin proteins. These N-terminal BAR, N-BAR, and EFC/F-BAR domains are found in proteins that regulate membrane trafficking events by inducing membrane tubulation. The domain dimerises into a curved structure that binds to liposomes and either senses or induces the curvature of the membrane bilayer to cause biophysical changes to the shape of the bilayer; it also thereby recruits other trafficking factors, such as the GTPase dynamin. Most EFC/F-BAR domain-family members localize to actin-rich structures.","GO:0007274|neuromuscular synaptic transmission;GO:0030833|regulation of actin filament polymerization;GO:0030838|positive regulation of actin filament polymerization;GO:0044803|multi-organism membrane organization;GO:0072583|clathrin-dependent endocytosis;GO:2000601|positive regulation of Arp2/3 complex-mediated actin nucleation;","GO:0005886|plasma membrane;GO:0005905|clathrin-coated pit;GO:0031594|neuromuscular junction;GO:0055037|recycling endosome;GO:0120043|stereocilium shaft;","GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;GO:0043325|phosphatidylinositol-3,4-bisphosphate binding;","K20125","FCHSD; F-BAR and double SH3 domains protein"]
["ENSRNOG00000002773",78,5.017774178,316,20.40154765,0.245950663,-2.023559149,{"v":1.85967e-35,"d":"1.86E-35"},{"v":4.51197E-35,"d":"4.51E-35"},"down","yes","Rgs4","protein_coding","chr13:81936775-81943068:-","gi|8394183|ref|NP_058910.1|",901,{"v":7e-111,"d":"7.00E-111"},"regulator of G-protein signaling 4 [Rattus norvegicus]","gi|8394182|ref|NM_017214.1|",2914,0,"Rattus norvegicus regulator of G-protein signaling 4 (Rgs4), mRNA","P49799",351,{"v":2e-112,"d":"2.00E-112"},"Regulator of G-protein signaling 4",".",".",".",".","pfam00615","RGS","Regulator of G protein signaling domain. RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.","GO:0001975|response to amphetamine;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007420|brain development;GO:0010460|positive regulation of heart rate;GO:0042220|response to cocaine;GO:0043278|response to morphine;GO:0043547|positive regulation of GTPase activity;GO:0045471|response to ethanol;GO:0045744|negative regulation of G protein-coupled receptor signaling pathway;GO:0051924|regulation of calcium ion transport;GO:0060160|negative regulation of dopamine receptor signaling pathway;GO:0061052|negative regulation of cell growth involved in cardiac muscle cell development;GO:0110053|regulation of actin filament organization;GO:1900924|negative regulation of glycine import across plasma membrane;GO:1901379|regulation of potassium ion transmembrane transport;GO:1901380|negative regulation of potassium ion transmembrane transport;GO:1990791|dorsal root ganglion development;GO:2000463|positive regulation of excitatory postsynaptic potential;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0032991|protein-containing complex;","GO:0001965|G-protein alpha-subunit binding;GO:0005096|GTPase activator activity;","K16449","RGS; regulator of G-protein signaling"]
["ENSRNOG00000018804",203,13.05907895,532,34.34690934,0.380211181,-1.395127138,{"v":2.74742e-35,"d":"2.75E-35"},{"v":6.64606e-35,"d":"6.65E-35"},"down","yes","Ripor2","protein_coding","chr17:40323867-40548092:-","gi|564391393|ref|XP_006253992.1|",5439,0,"PREDICTED: protein FAM65B isoform X2 [Rattus norvegicus]","gi|564391392|ref|XM_006253930.1|",5217,0,"PREDICTED: Rattus norvegicus family with sequence similarity 65, member B (Fam65b), transcript variant X2, mRNA","Q80U16",1979,0,"Rho family-interacting cell polarization regulator 2",".",".",".",".","pfam04065","Not3","Not1 N-terminal domain, CCR4-Not complex component.","GO:0006935|chemotaxis;GO:0007155|cell adhesion;GO:0007162|negative regulation of cell adhesion;GO:0007605|sensory perception of sound;GO:0035024|negative regulation of Rho protein signal transduction;GO:0042130|negative regulation of T cell proliferation;GO:0045184|establishment of protein localization;GO:0045663|positive regulation of myoblast differentiation;GO:0048741|skeletal muscle fiber development;GO:0051260|protein homooligomerization;GO:0051491|positive regulation of filopodium assembly;GO:0051726|regulation of cell cycle;GO:0060088|auditory receptor cell stereocilium organization;GO:0071260|cellular response to mechanical stimulus;GO:0090023|positive regulation of neutrophil chemotaxis;GO:1901673|regulation of mitotic spindle assembly;GO:1901741|positive regulation of myoblast fusion;GO:1903904|negative regulation of establishment of T cell polarity;GO:1905872|negative regulation of protein localization to cell leading edge;GO:1990869|cellular response to chemokine;GO:2000114|regulation of establishment of cell polarity;GO:2000391|positive regulation of neutrophil extravasation;GO:2000405|negative regulation of T cell migration;GO:2001107|negative regulation of Rho guanyl-nucleotide exchange factor activity;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0016324|apical plasma membrane;GO:0030175|filopodium;GO:0032420|stereocilium;GO:0060171|stereocilium membrane;","GO:0008199|ferric iron binding;GO:0042802|identical protein binding;GO:0071889|14-3-3 protein binding;","K24818","RIPOR, FAM65; Rho family-interacting cell polarization regulator"]
["ENSRNOG00000051216",37,2.380226213,229,14.78466586,0.160992899,-2.634931042,{"v":2.94012e-35,"d":"2.94E-35"},{"v":7.1062e-35,"d":"7.11E-35"},"down","yes","AABR07038983.1","lncRNA","chrX:61138374-61144585:+","gi|149042264|gb|EDL95971.1|",370,{"v":1e-37,"d":"1.00E-37"},"rCG63291 [Rattus norvegicus]","gi|30268441|emb|AL831708.9|",1620,0,"Mouse DNA sequence from clone RP23-23B17 on chromosome X, complete sequence",".",".",".",".",".",".",".",".","pfam06993","DUF1304","Protein of unknown function (DUF1304). This family consists of several hypothetical bacterial proteins of around 120 residues in length. The function of this family is unknown.",".",".",".",".","."]
["ENSRNOG00000003114",188,12.09412238,507,32.73286285,0.369479518,-1.436433705,{"v":3.76806E-35,"d":"3.77E-35"},{"v":9.08808e-35,"d":"9.09E-35"},"down","yes","B4galt4","protein_coding","chr11:61995814-62021671:-","gi|58865614|ref|NP_001012018.1|",1737,0,"beta-1,4-galactosyltransferase 4 [Rattus norvegicus]","gi|58865613|ref|NM_001012018.1|",2078,0,"Rattus norvegicus UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 4 (B4galt4), mRNA","Q66HH1",673,0,"Beta-1,4-galactosyltransferase 4",".",".",".",".","pfam13733","Glyco_transf_7N","N-terminal region of glycosyl transferase group 7. This is the N-terminal half of a family of galactosyltransferases from a wide range of Metazoa with three related galactosyltransferases activities, all three of which are possessed by one sequence in some cases. EC:2.4.1.90, N-acetyllactosamine synthase; EC:2.4.1.38, Beta-N-acetylglucosaminyl-glycopeptide beta-1,4- galactosyltransferase; and EC:2.4.1.22 Lactose synthase. Note that N-acetyllactosamine synthase is a component of Lactose synthase along with alpha-lactalbumin, in the absence of alpha-lactalbumin EC:2.4.1.90 is the catalysed reaction.","GO:0005975|carbohydrate metabolic process;GO:0006486|protein glycosylation;GO:0070085|glycosylation;","GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;GO:0032580|Golgi cisterna membrane;","GO:0003945|N-acetyllactosamine synthase activity;GO:0008378|galactosyltransferase activity;GO:0046872|metal ion binding;","K07969","B4GALT4; beta-1,4-galactosyltransferase 4 [EC:2.4.1.90 2.4.1.275 2.4.1.-]"]
["ENSRNOG00000008065",23,1.479600078,194,12.52500077,0.118131735,-3.081531505,{"v":5.23927E-35,"d":"5.24E-35"},{"v":1.26045E-34,"d":"1.26E-34"},"down","yes","Wwc1","protein_coding","chr10:20300833-20454497:-","gi|109490515|ref|XP_001066364.1|",4631,0,"PREDICTED: protein KIBRA isoform X1 [Rattus norvegicus]","gi|672067111|ref|XM_002727761.4|",3873,0,"PREDICTED: Rattus norvegicus WW and C2 domain containing 1 (Wwc1), transcript variant X1, mRNA","Q5SXA9",1736,0,"Protein KIBRA","SPBC16E9.11c",70.9,{"v":2e-11,"d":"2.00E-11"},"COG5021","pfam00397","WW","WW domain. The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006355|regulation of transcription, DNA-templated;GO:0016477|cell migration;GO:0035330|regulation of hippo signaling;GO:0035331|negative regulation of hippo signaling;GO:0043410|positive regulation of MAPK cascade;GO:0045893|positive regulation of transcription, DNA-templated;GO:0046621|negative regulation of organ growth;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0032587|ruffle membrane;GO:0032991|protein-containing complex;GO:0048471|perinuclear region of cytoplasm;","GO:0003713|transcription coactivator activity;GO:0019900|kinase binding;GO:0030674|protein binding, bridging;GO:0060090|molecular adaptor activity;","K16685","WWC1; protein KIBRA"]
["ENSRNOG00000018674",31,1.994243584,213,13.75167611,0.145018219,-2.785693929,{"v":8.22273e-35,"d":"8.22E-35"},{"v":1.97322e-34,"d":"1.97E-34"},"down","yes","Ntrk3","protein_coding","chr1:132132849-132503286:-","gi|397174822|ref|NP_001257585.1|",4471,0,"NT-3 growth factor receptor isoform 1 precursor [Rattus norvegicus]","gi|397174821|ref|NM_001270656.1|",2777,0,"Rattus norvegicus neurotrophic tyrosine kinase, receptor, type 3 (Ntrk3), transcript variant 1, mRNA","Q03351",1726,0,"NT-3 growth factor receptor",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001764|neuron migration;GO:0001933|negative regulation of protein phosphorylation;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007178|transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0007275|multicellular organism development;GO:0007507|heart development;GO:0007623|circadian rhythm;GO:0008284|positive regulation of cell proliferation;GO:0010628|positive regulation of gene expression;GO:0010976|positive regulation of neuron projection development;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0019056|modulation by virus of host transcription;GO:0019227|neuronal action potential propagation;GO:0022011|myelination in peripheral nervous system;GO:0030335|positive regulation of cell migration;GO:0032148|activation of protein kinase B activity;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0033674|positive regulation of kinase activity;GO:0038179|neurotrophin signaling pathway;GO:0042490|mechanoreceptor differentiation;GO:0043065|positive regulation of apoptotic process;GO:0043406|positive regulation of MAP kinase activity;GO:0043410|positive regulation of MAPK cascade;GO:0045471|response to ethanol;GO:0048013|ephrin receptor signaling pathway;GO:0048665|neuron fate specification;GO:0048678|response to axon injury;GO:0048691|positive regulation of axon extension involved in regeneration;GO:0048712|negative regulation of astrocyte differentiation;GO:0050927|positive regulation of positive chemotaxis;GO:0051412|response to corticosterone;GO:0051896|regulation of protein kinase B signaling;GO:0051965|positive regulation of synapse assembly;GO:0060548|negative regulation of cell death;GO:0070306|lens fiber cell differentiation;GO:0071300|cellular response to retinoic acid;GO:0090102|cochlea development;GO:0090630|activation of GTPase activity;GO:0099151|regulation of postsynaptic density assembly;GO:1905606|regulation of presynapse assembly;GO:1990090|cellular response to nerve growth factor stimulus;GO:2000251|positive regulation of actin cytoskeleton reorganization;","GO:0000139|Golgi membrane;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0030424|axon;GO:0043235|receptor complex;GO:0098978|glutamatergic synapse;GO:0099055|integral component of postsynaptic membrane;","GO:0002039|p53 binding;GO:0004675|transmembrane receptor protein serine/threonine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0005004|GPI-linked ephrin receptor activity;GO:0005030|neurotrophin receptor activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0043121|neurotrophin binding;","K05101","NTRK3, TRKC; neurotrophic tyrosine kinase, receptor type 3 [EC:2.7.10.1]"]
["ENSRNOG00000001854",70,4.503130673,297,19.17487232,0.234845406,-2.090216723,{"v":8.86056e-35,"d":"8.86E-35"},{"v":2.12271e-34,"d":"2.12E-34"},"down","yes","Tmtc1","protein_coding","chr4:181146251-181359289:-","gi|564349856|ref|XP_342789.5|",4569,0,"PREDICTED: transmembrane and TPR repeat-containing protein 1 isoform X3 [Rattus norvegicus]","gi|672051694|ref|XM_342788.6|",6065,0,"PREDICTED: Rattus norvegicus transmembrane and tetratricopeptide repeat containing 1 (Tmtc1), transcript variant X3, mRNA","Q3UV71",1716,0,"Transmembrane and TPR repeat-containing protein 1","MTH72",105,{"v":1E-22,"d":"1.00E-22"},"COG0457","pfam08409","DUF1736","Domain of unknown function (DUF1736). This domain of unknown function is found in various hypothetical metazoan proteins.","GO:0035269|protein O-linked mannosylation;","GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;","GO:0000030|mannosyltransferase activity;GO:0004169|dolichyl-phosphate-mannose-protein mannosyltransferase activity;","K23424","TMTC; protein O-mannosyl-transferase [EC:2.4.1.-]"]
["ENSRNOG00000046216",86,5.532417684,327,21.11172811,0.262054231,-1.93206269,{"v":1.43142e-34,"d":"1.43E-34"},{"v":3.41063e-34,"d":"3.41E-34"},"down","yes","RGD1559482","protein_coding","chr10:100156238-100182647:+","gi|564375252|ref|XP_006247801.1|",1012,{"v":4e-132,"d":"4.00E-132"},"PREDICTED: CMRF35-like molecule isoform X1 [Rattus norvegicus]","gi|672070034|ref|XM_006247739.2|",639,0,"PREDICTED: Rattus norvegicus immunoglobulin superfamily, member 7 (Igsf7), transcript variant X2, mRNA","Q7TSN2",261,{"v":7e-82,"d":"7.00E-82"},"CMRF35-like molecule",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0001819|positive regulation of cytokine production;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;",".","K06719","CD300; CD300 antigen"]
["ENSRNOG00000026702",136,8.748939593,416,26.85773362,0.325751224,-1.618157496,{"v":2.10037e-34,"d":"2.10E-34"},{"v":4.98788e-34,"d":"4.99E-34"},"down","yes","Jaml","protein_coding","chr8:45383495-45416565:+","gi|392341956|ref|XP_001067982.3|",1660,0,"PREDICTED: junctional adhesion molecule-like isoform X1 [Rattus norvegicus]","gi|672061707|ref|XM_236198.8|",1484,0,"PREDICTED: Rattus norvegicus adhesion molecule, interacts with CXADR antigen 1 (Amica1), transcript variant X1, mRNA","Q80UL9",484,{"v":1E-161,"d":"1.00E-161"},"Junctional adhesion molecule-like",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0030593|neutrophil chemotaxis;GO:0035696|monocyte extravasation;GO:0046629|gamma-delta T cell activation;GO:0060054|positive regulation of epithelial cell proliferation involved in wound healing;GO:0072672|neutrophil extravasation;","GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0005923|bicellular tight junction;GO:0016021|integral component of membrane;","GO:0005178|integrin binding;GO:0042803|protein homodimerization activity;GO:0050839|cell adhesion molecule binding;",".","."]
["ENSRNOG00000049056",306,19.68511408,684,44.160312,0.445764833,-1.165645292,{"v":2.42513e-34,"d":"2.43E-34"},{"v":5.74955e-34,"d":"5.75E-34"},"down","yes","AABR07051450.1","protein_coding","chr3:15912485-15923041:+","gi|830005084|ref|XP_004677358.2|",954,{"v":2E-121,"d":"2.00E-121"},"PREDICTED: adenylate kinase isoenzyme 1 isoform X1 [Condylura cristata]","gi|467091434|ref|NM_024349.3|",1974,0,"Rattus norvegicus adenylate kinase 1 (Ak1), mRNA","P39069",366,{"v":3e-121,"d":"3.00E-121"},"Adenylate kinase isoenzyme 1","YKL024c",157,{"v":5e-43,"d":"5.00E-43"},"COG0563","pfam00406","ADK","Adenylate kinase.",".",".",".",".","."]
["ENSRNOG00000014171",277,17.81953138,640,41.31959018,0.431261087,-1.213366548,{"v":2.98852E-34,"d":"2.99E-34"},{"v":7.07349e-34,"d":"7.07E-34"},"down","yes","Tnfsf13","protein_coding","chr10:54400065-54403042:-","gi|149053071|gb|EDM04888.1|",1275,{"v":2E-171,"d":"2.00E-171"},"tumor necrosis factor (ligand) superfamily, member 13 [Rattus norvegicus]","gi|57526848|ref|NM_001009623.1|",1628,0,"Rattus norvegicus tumor necrosis factor superfamily member 13 (Tnfsf13), mRNA","Q9D777",465,{"v":6e-161,"d":"6.00E-161"},"Tumor necrosis factor ligand superfamily member 13",".",".",".",".","pfam00229","TNF","TNF(tumor Necrosis Factor) family.","GO:0002636|positive regulation of germinal center formation;GO:0007165|signal transduction;GO:0008150|biological_process;GO:0008284|positive regulation of cell proliferation;GO:0016064|immunoglobulin mediated immune response;GO:0048298|positive regulation of isotype switching to IgA isotypes;GO:0050776|regulation of immune response;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0005125|cytokine activity;GO:0005164|tumor necrosis factor receptor binding;GO:0048018|receptor ligand activity;","K05475","TNFSF13, APRIL, CD256; tumor necrosis factor ligand superfamily member 13"]
["ENSRNOG00000003121",57,3.666834977,267,17.23801653,0.212717917,-2.232986537,{"v":5.32237e-34,"d":"5.32E-34"},{"v":1.25248E-33,"d":"1.25E-33"},"down","yes","Rtn4rl1","protein_coding","chr10:60043002-60116978:+","gi|31077122|ref|NP_852042.1|",2183,0,"reticulon-4 receptor-like 1 precursor [Rattus norvegicus]","gi|121583854|ref|NM_181377.3|",2945,0,"Rattus norvegicus reticulon 4 receptor-like 1 (Rtn4rl1), mRNA","Q80WD0",845,0,"Reticulon-4 receptor-like 1","SPy1798",57.8,2e-07,"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0007166|cell surface receptor signaling pathway;GO:0007411|axon guidance;GO:0010977|negative regulation of neuron projection development;GO:0022038|corpus callosum development;GO:0048681|negative regulation of axon regeneration;GO:0050919|negative chemotaxis;","GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0042995|cell projection;GO:0043204|perikaryon;GO:0045121|membrane raft;GO:0046658|anchored component of plasma membrane;","GO:0008201|heparin binding;GO:0035374|chondroitin sulfate binding;GO:0038023|signaling receptor activity;GO:0048495|Roundabout binding;","K16660","RTN4RL1, NGR3; reticulon-4 receptor-like 1"]
["ENSRNOG00000012964",4,0.257321753,138,8.909536632,0.028881609,-5.113705076,{"v":5.82495e-34,"d":"5.82E-34"},{"v":1.36849e-33,"d":"1.37E-33"},"down","yes","Ccr6","protein_coding","chr1:52474168-52498603:-","gi|61557091|ref|NP_001013163.1|",1803,0,"C-C chemokine receptor type 6 [Rattus norvegicus]","gi|672034413|ref|XM_008758755.1|",2940,0,"PREDICTED: Rattus norvegicus chemokine (C-C motif) receptor 6 (Ccr6), transcript variant X1, mRNA","O54689",610,0,"C-C chemokine receptor type 6",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0002523|leukocyte migration involved in inflammatory response;GO:0006935|chemotaxis;GO:0006955|immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0010634|positive regulation of epithelial cell migration;GO:0019722|calcium-mediated signaling;GO:0048290|isotype switching to IgA isotypes;GO:0060326|cell chemotaxis;GO:0060474|positive regulation of flagellated sperm motility involved in capacitation;GO:0070098|chemokine-mediated signaling pathway;GO:0072676|lymphocyte migration;GO:0072678|T cell migration;GO:0072679|thymocyte migration;GO:1904155|DN2 thymocyte differentiation;GO:1904156|DN3 thymocyte differentiation;GO:2000404|regulation of T cell migration;GO:2000510|positive regulation of dendritic cell chemotaxis;","GO:0005575|cellular_component;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0036126|sperm flagellum;GO:0097225|sperm midpiece;GO:0097228|sperm principal piece;GO:0097524|sperm plasma membrane;","GO:0003674|molecular_function;GO:0016493|C-C chemokine receptor activity;GO:0019957|C-C chemokine binding;","K04181","CCR6, CD196; C-C chemokine receptor type 6"]
["ENSRNOG00000006030",11,0.70763482,157,10.13621197,0.069812552,-3.84036975,{"v":6.9673e-34,"d":"6.97E-34"},{"v":1.63419e-33,"d":"1.63E-33"},"down","yes","ENSRNOG00000006030","protein_coding","chr4:51397601-51595218:+","gi|283046651|ref|NP_037212.2|",11637,0,"receptor-type tyrosine-protein phosphatase zeta isoform 1 precursor [Rattus norvegicus]","gi|283046650|ref|NM_013080.2|",7854,0,"Rattus norvegicus protein tyrosine phosphatase, receptor type Z1 (Ptprz1), transcript variant 1, mRNA","Q62656",4454,0,"Receptor-type tyrosine-protein phosphatase zeta","SPAC26F1.10c",147,{"v":2E-35,"d":"2.00E-35"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0002244|hematopoietic progenitor cell differentiation;GO:0006470|protein dephosphorylation;GO:0007409|axonogenesis;GO:0007413|axonal fasciculation;GO:0007420|brain development;GO:0007611|learning or memory;GO:0008285|negative regulation of cell proliferation;GO:0008542|visual learning;GO:0010812|negative regulation of cell-substrate adhesion;GO:0010976|positive regulation of neuron projection development;GO:0021766|hippocampus development;GO:0030335|positive regulation of cell migration;GO:0031641|regulation of myelination;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0043524|negative regulation of neuron apoptotic process;GO:0048146|positive regulation of fibroblast proliferation;GO:0048666|neuron development;GO:0048709|oligodendrocyte differentiation;GO:0048714|positive regulation of oligodendrocyte differentiation;GO:0048814|regulation of dendrite morphogenesis;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0070445|regulation of oligodendrocyte progenitor proliferation;GO:1900006|positive regulation of dendrite development;GO:1900149|positive regulation of Schwann cell migration;GO:1901216|positive regulation of neuron death;GO:2000171|negative regulation of dendrite development;GO:2001224|positive regulation of neuron migration;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030027|lamellipodium;GO:0030175|filopodium;GO:0030424|axon;GO:0030425|dendrite;GO:0030426|growth cone;GO:0031012|extracellular matrix;GO:0031226|intrinsic component of plasma membrane;GO:0032587|ruffle membrane;GO:0043025|neuronal cell body;GO:0043197|dendritic spine;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0072534|perineuronal net;GO:0098978|glutamatergic synapse;GO:0099061|integral component of postsynaptic density membrane;","GO:0004725|protein tyrosine phosphatase activity;GO:0005178|integrin binding;GO:0005515|protein binding;GO:0016791|phosphatase activity;GO:0017134|fibroblast growth factor binding;","K08114","PTPRZ; receptor-type tyrosine-protein phosphatase zeta [EC:3.1.3.48]"]
["ENSRNOG00000008010",8,0.514643505,148,9.555155229,0.053860298,-4.214633985,{"v":8.54368e-34,"d":"8.54E-34"},{"v":1.99982e-33,"d":"2.00E-33"},"down","yes","Hoxb5","protein_coding","chr10:81269372-81271580:+","gi|556738352|ref|XP_005964751.1|",1075,{"v":3e-141,"d":"3.00E-141"},"PREDICTED: homeobox protein Hox-B5 [Pantholops hodgsonii]","gi|672068879|ref|XM_008768104.1|",1534,0,"PREDICTED: Rattus norvegicus homeo box B5 (Hoxb5), transcript variant X1, mRNA","P09079",414,{"v":7e-141,"d":"7.00E-141"},"Homeobox protein Hox-B5",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0009952|anterior/posterior pattern specification;GO:0045446|endothelial cell differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048704|embryonic skeletal system morphogenesis;GO:0048706|embryonic skeletal system development;","GO:0001650|fibrillar center;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:1990837|sequence-specific double-stranded DNA binding;","K09305","HOX_5; homeobox protein HoxA/B/C5"]
["ENSRNOG00000055103",4,0.257321753,137,8.844974773,0.029092424,-5.103212702,{"v":1.03321E-33,"d":"1.03E-33"},{"v":2.41448E-33,"d":"2.41E-33"},"down","yes","Cftr","protein_coding","chr4:46560885-46728756:+","gi|564345828|ref|XP_006236159.1|",7356,0,"PREDICTED: cystic fibrosis transmembrane conductance regulator isoform X1 [Rattus norvegicus]","gi|91982739|ref|NM_031506.1|",6262,0,"Rattus norvegicus cystic fibrosis transmembrane conductance regulator (Cftr), mRNA","P34158",2769,0,"Cystic fibrosis transmembrane conductance regulator","SPBC359.05",269,{"v":1e-71,"d":"1.00E-71"},"COG1132","pfam14396","CFTR_R","Cystic fibrosis TM conductance regulator (CFTR), regulator domain.","GO:0006695|cholesterol biosynthetic process;GO:0006821|chloride transport;GO:0006833|water transport;GO:0006904|vesicle docking involved in exocytosis;GO:0007568|aging;GO:0009410|response to xenobiotic stimulus;GO:0015701|bicarbonate transport;GO:0030301|cholesterol transport;GO:0030321|transepithelial chloride transport;GO:0030324|lung development;GO:0032870|cellular response to hormone stimulus;GO:0033005|positive regulation of mast cell activation;GO:0034097|response to cytokine;GO:0034605|cellular response to heat;GO:0034976|response to endoplasmic reticulum stress;GO:0035377|transepithelial water transport;GO:0035725|sodium ion transmembrane transport;GO:0035774|positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0036253|response to amiloride;GO:0042311|vasodilation;GO:0043434|response to peptide hormone;GO:0043627|response to estrogen;GO:0045921|positive regulation of exocytosis;GO:0048240|sperm capacitation;GO:0050891|multicellular organismal water homeostasis;GO:0051454|intracellular pH elevation;GO:0055085|transmembrane transport;GO:0060081|membrane hyperpolarization;GO:0070166|enamel mineralization;GO:0070175|positive regulation of enamel mineralization;GO:0071320|cellular response to cAMP;GO:0071454|cellular response to anoxia;GO:0097186|amelogenesis;GO:0097421|liver regeneration;GO:1902161|positive regulation of cyclic nucleotide-gated ion channel activity;GO:1902476|chloride transmembrane transport;GO:1902943|positive regulation of voltage-gated chloride channel activity;GO:1904322|cellular response to forskolin;GO:1904446|positive regulation of establishment of Sertoli cell barrier;GO:1905460|negative regulation of vascular associated smooth muscle cell apoptotic process;GO:2000077|negative regulation of type B pancreatic cell development;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005769|early endosome;GO:0005789|endoplasmic reticulum membrane;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005902|microvillus;GO:0009986|cell surface;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0030425|dendrite;GO:0030659|cytoplasmic vesicle membrane;GO:0031901|early endosome membrane;GO:0032991|protein-containing complex;GO:0034707|chloride channel complex;GO:0043025|neuronal cell body;GO:0055037|recycling endosome;GO:0055038|recycling endosome membrane;","GO:0005254|chloride channel activity;GO:0005260|intracellularly ATP-gated chloride channel activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0015106|bicarbonate transmembrane transporter activity;GO:0015108|chloride transmembrane transporter activity;GO:0016853|isomerase activity;GO:0019869|chloride channel inhibitor activity;GO:0019899|enzyme binding;GO:0030165|PDZ domain binding;GO:0042626|ATPase activity, coupled to transmembrane movement of substances;GO:0051087|chaperone binding;GO:0106138|Sec61 translocon complex binding;","K05031","CFTR, ABCC7; cystic fibrosis transmembrane conductance regulator [EC:5.6.1.6]"]
["ENSRNOG00000014722",210,13.50939202,533,34.4114712,0.392583971,-1.348926824,{"v":1.14757E-33,"d":"1.15E-33"},{"v":2.67954e-33,"d":"2.68E-33"},"down","yes","Raph1","protein_coding","chr9:61907758-61961209:-","gi|568907061|ref|XP_006496385.1|",3580,0,"PREDICTED: ras-associated and pleckstrin homology domains-containing protein 1 isoform X1 [Mus musculus]","gi|341823647|ref|NM_001108798.2|",6360,0,"Rattus norvegicus Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 (Raph1), mRNA","Q70E73",1182,0,"Ras-associated and pleckstrin homology domains-containing protein 1",".",".",".",".","pfam00788","RA","Ras association (RalGDS/AF-6) domain. RasGTP effectors (in cases of AF6, canoe and RalGDS); putative RasGTP effectors in other cases. Recent evidence (not yet in MEDLINE) shows that some RA domains do NOT bind RasGTP. Predicted structure similar to that determined, and that of the RasGTP-binding domain of Raf kinase.","GO:0007165|signal transduction;GO:0008150|biological_process;GO:0048675|axon extension;","GO:0005575|cellular_component;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016604|nuclear body;GO:0031252|cell leading edge;","GO:0003674|molecular_function;","K23488","RAPH1; Ras-associated and pleckstrin homology domains-containing protein 1"]
["ENSRNOG00000070909",15,0.964956573,167,10.78183056,0.089498399,-3.481994316,{"v":1.45389E-33,"d":"1.45E-33"},{"v":3.38372e-33,"d":"3.38E-33"},"down","yes","ENSRNOG00000070909","protein_coding","chr4:70403737-70410534:+","gi|149065398|gb|EDM15474.1|",930,{"v":8e-112,"d":"8.00E-112"},"rCG64533, partial [Rattus norvegicus]","gi|207190|gb|M63793.1|RATTCBC1",5175,0,"Rattus norvegicus T-cell receptor beta-chain (Tcrb) gene, exons 1 through 4 and partial cds","P01852",327,{"v":1E-100,"d":"1.00E-100"},"T-cell receptor beta-1 chain C region",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.",".",".",".",".","."]
["ENSRNOG00000009949",146,9.392243975,428,27.63247593,0.339898748,-1.556823047,{"v":1.6301e-33,"d":"1.63E-33"},{"v":3.78918e-33,"d":"3.79E-33"},"down","yes","Pcdh18","protein_coding","chr2:133832001-133845883:-","gi|564336371|ref|XP_006232384.1|",5879,0,"PREDICTED: protocadherin-18 isoform X1 [Rattus norvegicus]","gi|672042330|ref|XM_006232322.2|",5087,0,"PREDICTED: Rattus norvegicus protocadherin 18 (Pcdh18), transcript variant X1, mRNA","Q8VHR0",2223,0,"Protocadherin 18",".",".",".",".","pfam00028","Cadherin","Cadherin domain.","GO:0007155|cell adhesion;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007420|brain development;","GO:0005887|integral component of plasma membrane;","GO:0005509|calcium ion binding;","K16499","PCDHD2; protocadherin delta 2"]
["ENSRNOG00000000007",5,0.321652191,138,8.909536632,0.036102011,-4.791776981,{"v":2.26927E-33,"d":"2.27E-33"},{"v":5.26422e-33,"d":"5.26E-33"},"down","yes","Gad1","protein_coding","chr3:55369704-55410333:+","gi|227913|prf||1713398A",3197,0,"Glu decarboxylase","gi|8393405|ref|NM_017007.1|",3157,0,"Rattus norvegicus glutamate decarboxylase 1 (Gad1), mRNA","P18088",1222,0,"Glutamate decarboxylase 1","SMa2402",184,{"v":1e-48,"d":"1.00E-48"},"COG0076","pfam00282","Pyridoxal_deC","Pyridoxal-dependent decarboxylase conserved domain.","GO:0009410|response to xenobiotic stimulus;GO:0009449|gamma-aminobutyric acid biosynthetic process;GO:0019752|carboxylic acid metabolic process;GO:0035176|social behavior;GO:0035641|locomotory exploration behavior;GO:0042136|neurotransmitter biosynthetic process;","GO:0005737|cytoplasm;GO:0005938|cell cortex;GO:0030424|axon;GO:0043679|axon terminus;GO:0044306|neuron projection terminus;GO:0045202|synapse;GO:0048786|presynaptic active zone;GO:0060077|inhibitory synapse;","GO:0004351|glutamate decarboxylase activity;GO:0016595|glutamate binding;GO:0016831|carboxy-lyase activity;GO:0030170|pyridoxal phosphate binding;GO:0044877|protein-containing complex binding;GO:0047485|protein N-terminus binding;","K01580","E4.1.1.15, gadB, gadA, GAD; glutamate decarboxylase [EC:4.1.1.15]"]
["ENSRNOG00000018851",29,1.865582707,202,13.04149565,0.143049751,-2.805411107,{"v":2.48815e-33,"d":"2.49E-33"},{"v":5.7657E-33,"d":"5.77E-33"},"down","yes","Ppp2r2b","protein_coding","chr18:34653721-35081025:-","gi|76880455|ref|NP_071545.2|",2349,0,"serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [Rattus norvegicus]","gi|440918726|ref|NM_022209.3|",1982,0,"Rattus norvegicus protein phosphatase 2, regulatory subunit B, beta (Ppp2r2b), transcript variant 1, mRNA","P36877",856,0,"Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform","SPAC227.07c",464,{"v":2e-154,"d":"2.00E-154"},"COG5170","pfam06578","YscK","YOP proteins translocation protein K (YscK). This family consists of several YscK proteins. The function of this protein is unknown but it belongs to an operon involved in the secretion of Yop proteins across bacterial membranes.","GO:0000266|mitochondrial fission;GO:0006626|protein targeting to mitochondrion;GO:0007286|spermatid development;GO:0007420|brain development;GO:0030182|neuron differentiation;GO:0043525|positive regulation of neuron apoptotic process;GO:0043653|mitochondrial fragmentation involved in apoptotic process;GO:0043666|regulation of phosphoprotein phosphatase activity;GO:0050790|regulation of catalytic activity;GO:0070262|peptidyl-serine dephosphorylation;","GO:0000159|protein phosphatase type 2A complex;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0016020|membrane;","GO:0005515|protein binding;GO:0019888|protein phosphatase regulator activity;GO:0044877|protein-containing complex binding;","K04354","PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B"]
["ENSRNOG00000008658",270,17.36921831,623,40.22203857,0.431833366,-1.211453375,{"v":2.62489e-33,"d":"2.62E-33"},{"v":6.07192E-33,"d":"6.07E-33"},"down","yes","Mitf","protein_coding","chr4:130409217-130621145:+","gi|300797624|ref|NP_001178018.1|",2368,0,"microphthalmia-associated transcription factor [Rattus norvegicus]","gi|694872204|ref|NM_001191089.2|",4770,0,"Rattus norvegicus microphthalmia-associated transcription factor (Mitf), mRNA","O88368",916,0,"Microphthalmia-associated transcription factor",".",".",".",".","pfam11851","DUF3371","Domain of unknown function (DUF3371). This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is typically between 125 to 142 amino acids in length.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006351|transcription, DNA-templated;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008150|biological_process;GO:0010468|regulation of gene expression;GO:0010628|positive regulation of gene expression;GO:0016055|Wnt signaling pathway;GO:0030154|cell differentiation;GO:0030316|osteoclast differentiation;GO:0030318|melanocyte differentiation;GO:0030336|negative regulation of cell migration;GO:0042127|regulation of cell proliferation;GO:0043010|camera-type eye development;GO:0043066|negative regulation of apoptotic process;GO:0043473|pigmentation;GO:0044336|canonical Wnt signaling pathway involved in negative regulation of apoptotic process;GO:0045165|cell fate commitment;GO:0045670|regulation of osteoclast differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046849|bone remodeling;GO:0065003|protein-containing complex assembly;GO:2000144|positive regulation of DNA-templated transcription, initiation;GO:2001141|regulation of RNA biosynthetic process;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0032991|protein-containing complex;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003700|DNA-binding transcription factor activity;GO:0046983|protein dimerization activity;GO:0070888|E-box binding;","K09455","MITF; microphthalmia-associated transcription factor"]
["ENSRNOG00000003597",66,4.24580892,282,18.20644442,0.23320363,-2.100337852,{"v":2.65682E-33,"d":"2.66E-33"},{"v":6.14328e-33,"d":"6.14E-33"},"down","yes","Tuba4a","protein_coding","chr9:76709614-76713918:-","gi|821032162|ref|XP_012355059.1|",2315,0,"PREDICTED: tubulin alpha-4A chain isoform X2 [Nomascus leucogenys]","gi|298905785|emb|FQ212913.1|",2021,0,"Rattus norvegicus TL0AAA50YL06 mRNA sequence","Q5XIF6",895,0,"Tubulin alpha-4A chain","SPBC800.05c",717,0,"COG5023","pfam03953","Tubulin_C","Tubulin C-terminal domain. This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).","GO:0000226|microtubule cytoskeleton organization;GO:0000278|mitotic cell cycle;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005874|microtubule;GO:0015630|microtubule cytoskeleton;","GO:0003674|molecular_function;GO:0003924|GTPase activity;GO:0005200|structural constituent of cytoskeleton;GO:0005525|GTP binding;GO:0019899|enzyme binding;GO:0019901|protein kinase binding;","K07374","TUBA; tubulin alpha"]
["ENSRNOG00000047957",79,5.082104617,306,19.75592905,0.257244527,-1.958787714,{"v":5.02992e-33,"d":"5.03E-33"},{"v":1.15743E-32,"d":"1.16E-32"},"down","yes","Traf5","protein_coding","chr13:103572314-103618709:-","gi|672027536|ref|XP_008762143.1|",2970,0,"PREDICTED: LOW QUALITY PROTEIN: TNF receptor-associated factor 5 isoform X1 [Rattus norvegicus]","gi|672027535|ref|XM_008763921.1|",1885,0,"PREDICTED: Rattus norvegicus similar to TNF receptor-associated factor 5 (LOC684173), transcript variant X1, mRNA","P70191",1107,0,"TNF receptor-associated factor 5",".",".",".",".","pfam00917","MATH","MATH domain. This motif has been called the Meprin And TRAF-Homology (MATH) domain. This domain is hugely expanded in the nematode C. elegans.",".",".",".",".","."]
["ENSRNOG00000019662",164,10.55019186,455,29.37564614,0.359147568,-1.47735135,{"v":5.24359e-33,"d":"5.24E-33"},{"v":1.20563e-32,"d":"1.21E-32"},"down","yes","Tm6sf1","protein_coding","chr1:135786381-135828443:+","gi|157817089|ref|NP_001101960.1|",1715,0,"transmembrane 6 superfamily member 1 [Rattus norvegicus]","gi|157817088|ref|NM_001108490.1|",2670,0,"Rattus norvegicus transmembrane 6 superfamily member 1 (Tm6sf1), mRNA","P58749",649,0,"Transmembrane 6 superfamily member 1",".",".",".",".","pfam10914","DUF2781","Protein of unknown function (DUF2781). This is a eukaryotic family of uncharacterized proteins. Some of the proteins in this family are annotated as membrane proteins.",".","GO:0005765|lysosomal membrane;GO:0016021|integral component of membrane;",".","K25361","TM6SF; transmembrane 6 superfamily"]
["ENSRNOG00000042193",0,0.032165219,152,9.813402668,3.277683E-3,-8.253108133,{"v":7.01996e-33,"d":"7.02E-33"},{"v":1.60823E-32,"d":"1.61E-32"},"down","yes","AABR07034729.1","protein_coding","chr11:81518181-81518675:+","gi|149019826|gb|EDL77974.1|",557,{"v":5E-71,"d":"5.00E-71"},"rCG36571, partial [Rattus norvegicus]","gi|204843|gb|M77356.1|RATIGLAB",352,0,"Rat (clone RLV007) Ig productively rearranged lambda chain VJ region mRNA, 5'end cds","P01728",170,{"v":3e-53,"d":"3.00E-53"},"Ig lambda-2 chain V region",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000018631",5,0.321652191,136,8.780412913,0.036632923,-4.770715366,{"v":7.27988e-33,"d":"7.28E-33"},{"v":1.66711E-32,"d":"1.67E-32"},"down","yes","Enkur","protein_coding","chr17:83690797-83714408:-","gi|157817252|ref|NP_001099596.1|",1106,{"v":9e-148,"d":"9.00E-148"},"enkurin [Rattus norvegicus]","gi|157817251|ref|NM_001106126.1|",1205,0,"Rattus norvegicus enkurin, TRPC channel interacting protein (Enkur), mRNA","Q6SP97",393,{"v":1E-134,"d":"1.00E-134"},"Enkurin",".",".",".",".","pfam13864","Enkurin","Calmodulin-binding. This is a family of apparent calmodulin-binding proteins found at high levels in the testis and vomeronasal organ and at lower levels in certain other tissues. Enkurin is a scaffold protein that binds PI3 kinase to sperm transient receptor potential (canonical) (TRPC) channels. The mammalian transient receptor potential (canonical) channels are the primary candidates for the Ca(2+) entry pathway activated by the hormones, growth factors, and neurotransmitters that exert their effect through activation of PLC. Calmodulin binds to the C-terminus of all TRPC channels, and dissociation of calmodulin from TRPC4 results in profound activation of the channel.","GO:0030317|flagellated sperm motility;GO:0061966|establishment of left/right asymmetry;","GO:0001669|acrosomal vesicle;GO:0036126|sperm flagellum;GO:0097228|sperm principal piece;GO:0097728|9+0 motile cilium;GO:0097729|9+2 motile cilium;","GO:0005516|calmodulin binding;","K25647","ENKUR; enkurin"]
["ENSRNOG00000019763",1,0.064330438,137,8.844974773,0.007273106,-7.103212702,{"v":1.03804E-32,"d":"1.04E-32"},{"v":2.3648E-32,"d":"2.36E-32"},"down","yes","Mlph","protein_coding","chr9:91507591-91542983:+","gi|564369514|ref|XP_006245466.1|",2754,0,"PREDICTED: melanophilin isoform X1 [Rattus norvegicus]","gi|672065683|ref|XM_006245404.2|",2867,0,"PREDICTED: Rattus norvegicus melanophilin (Mlph), transcript variant X1, mRNA","Q91V27",938,0,"Melanophilin",".",".",".",".","pfam02318","FYVE_2","FYVE-type zinc finger. This FYVE-type zinc finger is found at the N-terminus of effector proteins including rabphilin-3A and regulating synaptic membrane exocytosis protein 2.","GO:0006605|protein targeting;GO:0030318|melanocyte differentiation;GO:0032400|melanosome localization;GO:0043473|pigmentation;","GO:0001725|stress fiber;GO:0005815|microtubule organizing center;GO:0015629|actin cytoskeleton;GO:0016461|unconventional myosin complex;GO:0030425|dendrite;GO:0030864|cortical actin cytoskeleton;GO:0042470|melanosome;GO:0048471|perinuclear region of cytoplasm;","GO:0003779|actin binding;GO:0017022|myosin binding;GO:0030674|protein binding, bridging;GO:0031267|small GTPase binding;GO:0031489|myosin V binding;GO:0051010|microtubule plus-end binding;","K22235","MLPH; melanophilin"]
["ENSRNOG00000061813",82,5.275095931,310,20.01417649,0.263567973,-1.92375302,{"v":1.10484E-32,"d":"1.10E-32"},{"v":2.51599E-32,"d":"2.52E-32"},"down","yes","Ly6c","protein_coding","chr7:106959511-106963329:-","gi|9910398|ref|NP_064488.1|",500,{"v":1e-57,"d":"1.00E-57"},"Ly6-C antigen precursor [Rattus norvegicus]","gi|672075999|ref|XM_003751343.2|",727,0,"PREDICTED: Rattus norvegicus lymphocyte antigen 6B-like (LOC100911104), mRNA","Q63317",129,{"v":4e-34,"d":"4.00E-34"},"Lymphocyte antigen 6B",".",".",".",".","pfam00021","UPAR_LY6","u-PAR/Ly-6 domain. This extracellular disulphide bond rich domain is related to pfam00087.","GO:0095500|acetylcholine receptor signaling pathway;GO:2000272|negative regulation of signaling receptor activity;","GO:0005886|plasma membrane;GO:0045202|synapse;","GO:0030550|acetylcholine receptor inhibitor activity;GO:0033130|acetylcholine receptor binding;","K06846","LY6D_E_F_G6_H; lymphocyte antigen 6 complex locus protein D/E/F/G6/H"]
["ENSRNOG00000010265",225,14.47434859,549,35.44446095,0.408367011,-1.292061767,{"v":1.64718e-32,"d":"1.65E-32"},{"v":3.74206e-32,"d":"3.74E-32"},"down","yes","Ada","protein_coding","chr3:152398747-152447088:-","gi|18426812|ref|NP_569083.1|",1652,0,"adenosine deaminase [Rattus norvegicus]","gi|56961651|ref|NM_130399.2|",1222,0,"Rattus norvegicus adenosine deaminase (Ada), mRNA","Q920P6",640,0,"Adenosine deaminase","CAC3005",139,{"v":8e-36,"d":"8.00E-36"},"COG1816","pfam00962","A_deaminase","Adenosine/AMP deaminase.","GO:0000255|allantoin metabolic process;GO:0001666|response to hypoxia;GO:0001701|in utero embryonic development;GO:0001821|histamine secretion;GO:0001829|trophectodermal cell differentiation;GO:0001889|liver development;GO:0001890|placenta development;GO:0002314|germinal center B cell differentiation;GO:0002636|positive regulation of germinal center formation;GO:0002686|negative regulation of leukocyte migration;GO:0002906|negative regulation of mature B cell apoptotic process;GO:0006154|adenosine catabolic process;GO:0006157|deoxyadenosine catabolic process;GO:0006196|AMP catabolic process;GO:0007155|cell adhesion;GO:0007568|aging;GO:0009168|purine ribonucleoside monophosphate biosynthetic process;GO:0009410|response to xenobiotic stimulus;GO:0010460|positive regulation of heart rate;GO:0030324|lung development;GO:0030890|positive regulation of B cell proliferation;GO:0032261|purine nucleotide salvage;GO:0032263|GMP salvage;GO:0033089|positive regulation of T cell differentiation in thymus;GO:0033197|response to vitamin E;GO:0033632|regulation of cell-cell adhesion mediated by integrin;GO:0042110|T cell activation;GO:0042323|negative regulation of circadian sleep/wake cycle, non-REM sleep;GO:0042542|response to hydrogen peroxide;GO:0043066|negative regulation of apoptotic process;GO:0043103|hypoxanthine salvage;GO:0043278|response to morphine;GO:0044209|AMP salvage;GO:0045187|regulation of circadian sleep/wake cycle, sleep;GO:0045580|regulation of T cell differentiation;GO:0045582|positive regulation of T cell differentiation;GO:0045987|positive regulation of smooth muscle contraction;GO:0046059|dAMP catabolic process;GO:0046061|dATP catabolic process;GO:0046085|adenosine metabolic process;GO:0046101|hypoxanthine biosynthetic process;GO:0046103|inosine biosynthetic process;GO:0046111|xanthine biosynthetic process;GO:0046638|positive regulation of alpha-beta T cell differentiation;GO:0048286|lung alveolus development;GO:0048541|Peyer's patch development;GO:0048566|embryonic digestive tract development;GO:0050728|negative regulation of inflammatory response;GO:0050850|positive regulation of calcium-mediated signaling;GO:0050862|positive regulation of T cell receptor signaling pathway;GO:0050870|positive regulation of T cell activation;GO:0060169|negative regulation of adenosine receptor signaling pathway;GO:0060407|negative regulation of penile erection;GO:0070244|negative regulation of thymocyte apoptotic process;GO:0070256|negative regulation of mucus secretion;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0030054|cell junction;GO:0032839|dendrite cytoplasm;GO:0043025|neuronal cell body;GO:0060205|cytoplasmic vesicle lumen;","GO:0001883|purine nucleoside binding;GO:0004000|adenosine deaminase activity;GO:0008270|zinc ion binding;GO:0046936|deoxyadenosine deaminase activity;","K01488","add, ADA; adenosine deaminase [EC:3.5.4.4]"]
["ENSRNOG00000050215",46,2.959200157,237,15.30116074,0.193397103,-2.370361912,{"v":1.66571e-32,"d":"1.67E-32"},{"v":3.78266e-32,"d":"3.78E-32"},"down","yes","AABR07044375.1","protein_coding","chr20:3179438-3184250:-","gi|109509676|ref|XP_001057922.1|",1239,{"v":2e-158,"d":"2.00E-158"},"PREDICTED: corneodesmosin isoform X1 [Rattus norvegicus]","gi|672031497|ref|XM_001057922.3|",2309,0,"PREDICTED: Rattus norvegicus similar to corneodesmosin (LOC682408), transcript variant X1, mRNA","Q7TPC1",389,{"v":1e-123,"d":"1.00E-123"},"Corneodesmosin",".",".",".",".","pfam07223","DUF1421","Protein of unknown function (DUF1421). This family represents a conserved region approximately 350 residues long within a number of plant proteins of unknown function.","GO:0003336|corneocyte desquamation;GO:0008150|biological_process;GO:0043589|skin morphogenesis;GO:0098609|cell-cell adhesion;GO:1905716|negative regulation of cornification;","GO:0001533|cornified envelope;GO:0005576|extracellular region;GO:0005737|cytoplasm;GO:0030057|desmosome;","GO:0003674|molecular_function;GO:0042803|protein homodimerization activity;","K23457","CDSN; corneodesmosin"]
["ENSRNOG00000008184",31,1.994243584,203,13.10605751,0.152161974,-2.716320226,{"v":1.95854e-32,"d":"1.96E-32"},{"v":4.43707e-32,"d":"4.44E-32"},"down","yes","Esrp1","protein_coding","chr5:24428717-24482062:-","gi|564350329|ref|XP_006237938.1|",3484,0,"PREDICTED: epithelial splicing regulatory protein 1 isoform X1 [Rattus norvegicus]","gi|672051999|ref|XM_006237876.2|",2786,0,"PREDICTED: Rattus norvegicus epithelial splicing regulatory protein 1 (Esrp1), transcript variant X1, mRNA","B2RYD2",1341,0,"Epithelial splicing regulatory protein 1",".",".",".",".","pfam14259","RRM_6","RNA recognition motif (a.k.a. RRM, RBD, or RNP domain).","GO:0000380|alternative mRNA splicing, via spliceosome;GO:0042669|regulation of inner ear auditory receptor cell fate specification;GO:0043484|regulation of RNA splicing;GO:0050679|positive regulation of epithelial cell proliferation;GO:0060441|epithelial tube branching involved in lung morphogenesis;GO:0060445|branching involved in salivary gland morphogenesis;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0016604|nuclear body;GO:1990904|ribonucleoprotein complex;","GO:0003723|RNA binding;GO:0003729|mRNA binding;","K14947","ESRP1_2; epithelial splicing regulatory protein 1/2"]
["ENSRNOG00000018247",94,6.047061189,331,21.36997555,0.282969963,-1.821279174,{"v":2.00935e-32,"d":"2.01E-32"},{"v":4.55036e-32,"d":"4.55E-32"},"down","yes","Dhx58","protein_coding","chr10:85620357-85631525:-","gi|149408137|ref|NP_001092258.1|",3585,0,"probable ATP-dependent RNA helicase DHX58 [Rattus norvegicus]","gi|672068688|ref|XM_006247315.2|",2373,0,"PREDICTED: Rattus norvegicus DEXH (Asp-Glu-X-His) box polypeptide 58 (Dhx58), transcript variant X2, mRNA","Q99J87",1266,0,"Probable ATP-dependent RNA helicase DHX58","TVN1490",130,{"v":5e-31,"d":"5.00E-31"},"COG1111","pfam11648","RIG-I_C-RD","C-terminal domain of RIG-I. This family of proteins represents the regulatory domain RD of RIG-I, a protein which initiates a signalling cascade that provides essential antiviral protection for the host. The RD domain binds viral RNA, activating the RIG-I ATPase by RNA-dependant dimerization. The structure of RD contains a zinc-binding domain and is thought to confer ligand specificity.","GO:0009615|response to virus;GO:0009617|response to bacterium;GO:0032480|negative regulation of type I interferon production;GO:0032481|positive regulation of type I interferon production;GO:0032728|positive regulation of interferon-beta production;GO:0039534|negative regulation of MDA-5 signaling pathway;GO:0039536|negative regulation of RIG-I signaling pathway;GO:0045087|innate immune response;GO:0045088|regulation of innate immune response;GO:0045824|negative regulation of innate immune response;GO:0051607|defense response to virus;GO:1900245|positive regulation of MDA-5 signaling pathway;GO:1900246|positive regulation of RIG-I signaling pathway;","GO:0005737|cytoplasm;","GO:0003677|DNA binding;GO:0003724|RNA helicase activity;GO:0003725|double-stranded RNA binding;GO:0003727|single-stranded RNA binding;GO:0005524|ATP binding;GO:0008270|zinc ion binding;","K12649","DHX58, LGP2; ATP-dependent RNA helicase DHX58 [EC:3.6.4.13]"]
["ENSRNOG00000014795",107,6.883356886,354,22.85489832,0.301176439,-1.731319183,{"v":2.4757e-32,"d":"2.48E-32"},{"v":5.59759e-32,"d":"5.60E-32"},"down","yes","Nr2f1","protein_coding","chr2:8040377-8050123:-","gi|617641336|ref|XP_007531719.1|",1878,0,"PREDICTED: COUP transcription factor 1 isoform X1 [Erinaceus europaeus]","gi|111185901|ref|NM_010151.2|",1957,0,"Mus musculus nuclear receptor subfamily 2, group F, member 1 (Nr2f1), mRNA","Q60632",723,0,"COUP transcription factor 1",".",".",".",".","pfam00105","zf-C4","Zinc finger, C4 type (two domains). In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001764|neuron migration;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007399|nervous system development;GO:0010468|regulation of gene expression;GO:0010977|negative regulation of neuron projection development;GO:0021796|cerebral cortex regionalization;GO:0030154|cell differentiation;GO:0030522|intracellular receptor signaling pathway;GO:0030900|forebrain development;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048856|anatomical structure development;GO:1903800|positive regulation of production of miRNAs involved in gene silencing by miRNA;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0004879|nuclear receptor activity;GO:0008270|zinc ion binding;GO:0043565|sequence-specific DNA binding;GO:0044323|retinoic acid-responsive element binding;GO:1990837|sequence-specific double-stranded DNA binding;","K08547","NR2F1, TFCOUP1; COUP transcription factor 1"]
["ENSRNOG00000026060",46,2.959200157,236,15.23659888,0.194216582,-2.364261713,{"v":2.78463e-32,"d":"2.78E-32"},{"v":6.28861e-32,"d":"6.29E-32"},"down","yes","Arsi","protein_coding","chr18:54364088-54371767:+","gi|114145559|ref|NP_001041346.1|",2844,0,"arylsulfatase I precursor [Rattus norvegicus]","gi|114145558|ref|NM_001047881.1|",1722,0,"Rattus norvegicus arylsulfatase family, member I (Arsi), mRNA","Q32KI9",1083,0,"Arylsulfatase I","CC1172",169,{"v":2e-43,"d":"2.00E-43"},"COG3119","pfam00884","Sulfatase","Sulfatase.",".","GO:0005576|extracellular region;GO:0005783|endoplasmic reticulum;","GO:0008484|sulfuric ester hydrolase activity;GO:0046872|metal ion binding;","K12375","ARSI_J; arylsulfatase I/J [EC:3.1.6.-]"]
["ENSRNOG00000014448",202,12.99474851,510,32.92654842,0.394658691,-1.341322573,{"v":5.05613e-32,"d":"5.06E-32"},{"v":1.13511E-31,"d":"1.14E-31"},"down","yes","Arntl","protein_coding","chr1:167331633-167430231:+","gi|817283650|ref|XP_012312038.1|",3111,0,"PREDICTED: aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X3 [Aotus nancymaae]","gi|672037826|ref|XM_008759716.1|",2245,0,"PREDICTED: Rattus norvegicus aryl hydrocarbon receptor nuclear translocator-like (Arntl), transcript variant X2, mRNA","Q9EPW1",1177,0,"Aryl hydrocarbon receptor nuclear translocator-like protein 1",".",".",".",".","pfam14598","PAS_11","PAS domain. This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).","GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006606|protein import into nucleus;GO:0007283|spermatogenesis;GO:0007623|circadian rhythm;GO:0032007|negative regulation of TOR signaling;GO:0032922|circadian regulation of gene expression;GO:0042176|regulation of protein catabolic process;GO:0042634|regulation of hair cycle;GO:0042753|positive regulation of circadian rhythm;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045599|negative regulation of fat cell differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050767|regulation of neurogenesis;GO:0050796|regulation of insulin secretion;GO:0051726|regulation of cell cycle;GO:0051775|response to redox state;GO:0060137|maternal process involved in parturition;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:0090403|oxidative stress-induced premature senescence;GO:0120163|negative regulation of cold-induced thermogenesis;GO:1901985|positive regulation of protein acetylation;GO:2000074|regulation of type B pancreatic cell development;GO:2000323|negative regulation of glucocorticoid receptor signaling pathway;GO:2000772|regulation of cellular senescence;GO:2001016|positive regulation of skeletal muscle cell differentiation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005737|cytoplasm;GO:0016604|nuclear body;GO:0016605|PML body;GO:0033391|chromatoid body;GO:0034751|aryl hydrocarbon receptor complex;GO:0043231|intracellular membrane-bounded organelle;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0017162|aryl hydrocarbon receptor binding;GO:0043425|bHLH transcription factor binding;GO:0043565|sequence-specific DNA binding;GO:0046982|protein heterodimerization activity;GO:0046983|protein dimerization activity;GO:0051879|Hsp90 protein binding;GO:0070888|E-box binding;GO:1990837|sequence-specific double-stranded DNA binding;","K02296","ARNTL, BMAL1, CYC; aryl hydrocarbon receptor nuclear translocator-like protein 1"]
["ENSRNOG00000007455",8,0.514643505,141,9.103222211,0.056534213,-4.144731972,{"v":5.38144e-32,"d":"5.38E-32"},{"v":1.20719e-31,"d":"1.21E-31"},"down","yes","Tmem132e","protein_coding","chr10:67330751-67386789:+","gi|672068449|ref|XP_008766187.1|",4605,0,"PREDICTED: transmembrane protein 132E isoform X1 [Rattus norvegicus]","gi|672068448|ref|XM_008767965.1|",4466,0,"PREDICTED: Rattus norvegicus transmembrane protein 132E (Tmem132e), transcript variant X1, mRNA","Q6IEE6",1345,0,"Transmembrane protein 132E",".",".",".",".","pfam06003","SMN","Survival motor neuron protein (SMN). This family consists of several eukaryotic survival motor neuron (SMN) proteins. The Survival of Motor Neurons (SMN) protein, the product of the spinal muscular atrophy-determining gene, is part of a large macromolecular complex (SMN complex) that functions in the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs). The SMN complex functions as a specificity factor essential for the efficient assembly of Sm proteins on U snRNAs and likely protects cells from illicit, and potentially deleterious, non-specific binding of Sm proteins to RNAs.","GO:0008150|biological_process;GO:0035677|posterior lateral line neuromast hair cell development;","GO:0005575|cellular_component;GO:0016021|integral component of membrane;GO:0044297|cell body;","GO:0003674|molecular_function;","K17599","TMEM132; transmembrane protein 132"]
["ENSRNOG00000028335",314,20.19975759,678,43.77294085,0.461466769,-1.115701334,{"v":7.36855e-32,"d":"7.37E-32"},{"v":1.65036e-31,"d":"1.65E-31"},"down","yes","Fat4","protein_coding","chr2:121927942-122056707:+","gi|300794761|ref|NP_001178634.1|",25994,0,"protocadherin Fat 4 [Rattus norvegicus]","gi|672042110|ref|XM_006232292.2|",16601,0,"PREDICTED: Rattus norvegicus FAT atypical cadherin 4 (Fat4), transcript variant X1, mRNA","Q2PZL6",9791,0,"Protocadherin Fat 4",".",".",".",".","pfam00028","Cadherin","Cadherin domain.","GO:0001658|branching involved in ureteric bud morphogenesis;GO:0001822|kidney development;GO:0003007|heart morphogenesis;GO:0007009|plasma membrane organization;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007219|Notch signaling pathway;GO:0008543|fibroblast growth factor receptor signaling pathway;GO:0021987|cerebral cortex development;GO:0022008|neurogenesis;GO:0035329|hippo signaling;GO:0043931|ossification involved in bone maturation;GO:0048565|digestive tract development;GO:0060122|inner ear receptor cell stereocilium organization;GO:0072006|nephron development;GO:0072137|condensed mesenchymal cell proliferation;GO:0072307|regulation of metanephric nephron tubule epithelial cell differentiation;GO:0098609|cell-cell adhesion;","GO:0005886|plasma membrane;GO:0045177|apical part of cell;","GO:0005509|calcium ion binding;","K16669","FAT4; protocadherin Fat 4"]
["ENSRNOG00000069588",80,5.146435055,302,19.49768162,0.263951128,-1.921657264,{"v":7.71072e-32,"d":"7.71E-32"},{"v":1.72632e-31,"d":"1.73E-31"},"down","yes","ENSRNOG00000069588","lncRNA","chr3:147026672-147040850:+","gi|149043067|gb|EDL96641.1|",320,{"v":4e-31,"d":"4.00E-31"},"RGD1563912 (predicted), isoform CRA_a [Rattus norvegicus]","gi|672047553|ref|XR_352761.2|",1179,0,"PREDICTED: Rattus norvegicus small nucleolar RNA host gene 11 (non-protein coding) (Snhg11), transcript variant X1, misc_RNA","Q9WJR5",58.2,7e-07,"Endogenous retrovirus group K member 19 Pol protein",".",".",".",".","pfam00665","rve","Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyses the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.",".",".",".",".","."]
["ENSRNOG00000010076",5,0.321652191,131,8.457603615,0.038031126,-4.716675526,{"v":1.34876e-31,"d":"1.35E-31"},{"v":3.01023e-31,"d":"3.01E-31"},"down","yes","Pkp1","protein_coding","chr13:47309614-47357465:-","gi|564380756|ref|XP_006249946.1|",3774,0,"PREDICTED: plakophilin-1 isoform X1 [Rattus norvegicus]","gi|672074117|ref|XM_006249884.2|",4684,0,"PREDICTED: Rattus norvegicus plakophilin 1 (Pkp1), transcript variant X1, mRNA","P97350",1423,0,"Plakophilin-1",".",".",".",".","pfam00514","Arm","Armadillo/beta-catenin-like repeat. Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.","GO:0007043|cell-cell junction assembly;GO:0008150|biological_process;GO:0010628|positive regulation of gene expression;GO:0045110|intermediate filament bundle assembly;GO:0098609|cell-cell adhesion;GO:1902373|negative regulation of mRNA catabolic process;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005912|adherens junction;GO:0030057|desmosome;GO:1990124|messenger ribonucleoprotein complex;","GO:0003674|molecular_function;GO:0005521|lamin binding;GO:0045296|cadherin binding;","K10387","PKP1; plakophilin 1"]
["ENSRNOG00000037148",86,5.532417684,312,20.14330021,0.274652993,-1.864318084,{"v":1.35352e-31,"d":"1.35E-31"},{"v":3.01968e-31,"d":"3.02E-31"},"down","yes","Adap2","protein_coding","chr10:65138020-65165604:+","gi|880920145|ref|XP_005077039.2|",1804,0,"PREDICTED: arf-GAP with dual PH domain-containing protein 2 isoform X1 [Mesocricetus auratus]","gi|9910339|ref|NM_020101.1|",1640,0,"Rattus norvegicus ArfGAP with dual PH domains 2 (Adap2), mRNA","Q9JK15",696,0,"Arf-GAP with dual PH domain-containing protein 2","SPBC21D10.05c",71.2,{"v":5e-12,"d":"5.00E-12"},"COG5347","pfam01412","ArfGap","Putative GTPase activating protein for Arf. Putative zinc fingers with GTPase activating proteins (GAPs) towards the small GTPase, Arf. The GAP of ARD1 stimulates GTPase hydrolysis for ARD1 but not ARFs.","GO:0007507|heart development;GO:0043547|positive regulation of GTPase activity;GO:0048017|inositol lipid-mediated signaling;","GO:0005737|cytoplasm;GO:0005740|mitochondrial envelope;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0005096|GTPase activator activity;GO:0005545|1-phosphatidylinositol binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;GO:0043325|phosphatidylinositol-3,4-bisphosphate binding;GO:0043533|inositol 1,3,4,5 tetrakisphosphate binding;GO:0046872|metal ion binding;GO:1902936|phosphatidylinositol bisphosphate binding;","K23781","ADAP, CENTA; Arf-GAP with dual PH domain-containing protein"]
["ENSRNOG00000007765",80,5.146435055,300,19.3685579,0.265710802,-1.912071215,{"v":1.93309e-31,"d":"1.93E-31"},{"v":4.29591e-31,"d":"4.30E-31"},"down","yes","Frzb","protein_coding","chr3:65332277-65365208:-","gi|197313632|ref|NP_001093997.1|",1631,0,"secreted frizzled-related protein 3 precursor [Rattus norvegicus]","gi|197313631|ref|NM_001100527.1|",2737,0,"Rattus norvegicus frizzled-related protein (Frzb), mRNA","P97401",620,0,"Secreted frizzled-related protein 3",".",".",".",".","pfam01392","Fz","Fz domain. Also known as the CRD (cysteine rich domain), the C6 box in MuSK receptor. This domain of unknown function has been independently identified by several groups. The domain contains 10 conserved cysteines.","GO:0008150|biological_process;GO:0008285|negative regulation of cell proliferation;GO:0010721|negative regulation of cell development;GO:0014033|neural crest cell differentiation;GO:0030178|negative regulation of Wnt signaling pathway;GO:0030308|negative regulation of cell growth;GO:0035567|non-canonical Wnt signaling pathway;GO:0042472|inner ear morphogenesis;GO:0043065|positive regulation of apoptotic process;GO:0045600|positive regulation of fat cell differentiation;GO:0060029|convergent extension involved in organogenesis;GO:0060070|canonical Wnt signaling pathway;GO:0061037|negative regulation of cartilage development;GO:0061053|somite development;GO:0070367|negative regulation of hepatocyte differentiation;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0090103|cochlea morphogenesis;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005737|cytoplasm;","GO:0003674|molecular_function;GO:0017147|Wnt-protein binding;","K25481","FRZB, SFRP3; secreted frizzled-related protein 3"]
["ENSRNOG00000014443",66,4.24580892,273,17.62538769,0.240891661,-2.053543641,{"v":2.01185e-31,"d":"2.01E-31"},{"v":4.46919e-31,"d":"4.47E-31"},"down","yes","Pde5a","protein_coding","chr2:210858063-210999701:+","gi|564338675|ref|XP_006233322.1|",4645,0,"PREDICTED: cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [Rattus norvegicus]","gi|672043977|ref|XM_006233260.2|",3325,0,"PREDICTED: Rattus norvegicus phosphodiesterase 5A, cGMP-specific (Pde5a), transcript variant X1, mRNA","Q8CG03",1744,0,"cGMP-specific 3',5'-cyclic phosphodiesterase",".",".",".",".","pfam00233","PDEase_I","3'5'-cyclic nucleotide phosphodiesterase.","GO:0001666|response to hypoxia;GO:0002026|regulation of the force of heart contraction;GO:0002678|positive regulation of chronic inflammatory response;GO:0007165|signal transduction;GO:0007399|nervous system development;GO:0007614|short-term memory;GO:0010613|positive regulation of cardiac muscle hypertrophy;GO:0010749|regulation of nitric oxide mediated signal transduction;GO:0032496|response to lipopolysaccharide;GO:0033574|response to testosterone;GO:0042130|negative regulation of T cell proliferation;GO:0042311|vasodilation;GO:0043065|positive regulation of apoptotic process;GO:0043406|positive regulation of MAP kinase activity;GO:0045907|positive regulation of vasoconstriction;GO:0046068|cGMP metabolic process;GO:0046069|cGMP catabolic process;GO:0055118|negative regulation of cardiac muscle contraction;GO:0055119|relaxation of cardiac muscle;GO:0060282|positive regulation of oocyte development;","GO:0005829|cytosol;","GO:0004112|cyclic-nucleotide phosphodiesterase activity;GO:0004114|3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0030553|cGMP binding;GO:0046872|metal ion binding;GO:0047555|3',5'-cyclic-GMP phosphodiesterase activity;","K13762","PDE5; cGMP-specific 3',5'-cyclic phosphodiesterase [EC:3.1.4.35]"]
["ENSRNOG00000010941",131,8.427287402,390,25.17912527,0.334693414,-1.579087932,{"v":2.70355e-31,"d":"2.70E-31"},{"v":5.99178E-31,"d":"5.99E-31"},"down","yes","Tifa","protein_coding","chr2:216234774-216267841:+","gi|62078819|ref|NP_001014066.1|",984,{"v":2e-126,"d":"2.00E-126"},"TRAF-interacting protein with FHA domain-containing protein A [Rattus norvegicus]","gi|672044015|ref|XM_008761463.1|",1856,0,"PREDICTED: Rattus norvegicus TRAF-interacting protein with forkhead-associated domain (Tifa), transcript variant X1, mRNA","Q5XIB9",383,{"v":7E-128,"d":"7.00E-128"},"TRAF-interacting protein with FHA domain-containing protein A",".",".",".",".","pfam13579","Glyco_trans_4_4","Glycosyl transferase 4-like domain.","GO:0002753|cytoplasmic pattern recognition receptor signaling pathway;GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045087|innate immune response;GO:0051260|protein homooligomerization;","GO:0005737|cytoplasm;",".","K23826","TIFA; TRAF-interacting protein with FHA domain-containing protein A"]
["ENSRNOG00000018297",114,7.333669953,360,23.24226948,0.315531578,-1.664143702,{"v":3.69597e-31,"d":"3.70E-31"},{"v":8.17221e-31,"d":"8.17E-31"},"down","yes","Marveld2","protein_coding","chr2:31657220-31764150:-","gi|40254754|ref|NP_112619.2|",2542,0,"occludin [Rattus norvegicus]","gi|40254753|ref|NM_031329.2|",4055,0,"Rattus norvegicus occludin (Ocln), mRNA","Q6P6T5",988,0,"Occludin",".",".",".",".","pfam07303","Occludin_ELL","Occludin homology domain. This domain represents a conserved region approximately 100 residues long within eukaryotic occludin proteins and the RNA polymerase II elongation factor ELL. Occludin is an integral membrane protein that localizes to tight junctions, while ELL is an elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by polymerase at multiple sites along the DNA. This shared domain is thought to mediate protein interactions.","GO:0001933|negative regulation of protein phosphorylation;GO:0010592|positive regulation of lamellipodium assembly;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010827|regulation of glucose transmembrane transport;GO:0031116|positive regulation of microtubule polymerization;GO:0045216|cell-cell junction organization;GO:0046326|positive regulation of glucose import;GO:0070673|response to interleukin-18;GO:0070830|bicellular tight junction assembly;GO:0071356|cellular response to tumor necrosis factor;GO:0090303|positive regulation of wound healing;GO:0120193|tight junction organization;GO:1902463|protein localization to cell leading edge;GO:1905605|positive regulation of maintenance of permeability of blood-brain barrier;","GO:0005765|lysosomal membrane;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0005923|bicellular tight junction;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0016327|apicolateral plasma membrane;GO:0016328|lateral plasma membrane;GO:0030054|cell junction;GO:0030139|endocytic vesicle;GO:0031252|cell leading edge;GO:0031410|cytoplasmic vesicle;GO:0032991|protein-containing complex;GO:0070160|tight junction;","GO:0005515|protein binding;GO:0019904|protein domain specific binding;","K06088","OCLN; occludin"]
["ENSRNOG00000006990",12,0.771965258,149,9.619717089,0.080248229,-3.639386639,{"v":4.15502e-31,"d":"4.16E-31"},{"v":9.16593e-31,"d":"9.17E-31"},"down","yes","Grb7","protein_coding","chr10:83444004-83453052:+","gi|564374464|ref|XP_006247496.1|",2441,0,"PREDICTED: growth factor receptor-bound protein 7 isoform X2 [Rattus norvegicus]","gi|672068943|ref|XM_006247434.2|",2083,0,"PREDICTED: Rattus norvegicus growth factor receptor bound protein 7 (Grb7), transcript variant X4, mRNA","Q9QZC5",907,0,"Growth factor receptor-bound protein 7",".",".",".",".","pfam08947","BPS","BPS (Between PH and SH2). The BPS (Between PH and SH2) domain, comprised of 2 beta strands and a C-terminal helix, is an approximately 45 residue region found in the adaptor proteins Grb7/10/14 that mediates inhibition of the tyrosine kinase domain of the insulin receptor by binding of the N-terminal portion of the BPS domain to the substrate peptide groove of the kinase, acting as a pseudosubstrate inhibitor.","GO:0017148|negative regulation of translation;GO:0030335|positive regulation of cell migration;GO:0034063|stress granule assembly;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005925|focal adhesion;GO:0010494|cytoplasmic stress granule;GO:0042995|cell projection;","GO:0003723|RNA binding;GO:0005515|protein binding;GO:0019901|protein kinase binding;GO:0035091|phosphatidylinositol binding;GO:0042802|identical protein binding;","K23695","GRB7; growth factor receptor-bound protein 7"]
["ENSRNOG00000015691",33,2.12290446,202,13.04149565,0.162780751,-2.618997983,{"v":4.17846e-31,"d":"4.18E-31"},{"v":9.21409e-31,"d":"9.21E-31"},"down","yes","Inka2","protein_coding","chr2:193185275-193200642:+","gi|157819183|ref|NP_001101183.1|",1379,{"v":2e-178,"d":"2.00E-178"},"protein FAM212B [Rattus norvegicus]","gi|157819182|ref|NM_001107713.1|",3359,0,"Rattus norvegicus family with sequence similarity 212, member B (Fam212b), mRNA","Q80VY2",481,{"v":6e-159,"d":"6.00E-159"},"PAK4-inhibitor INKA2",".",".",".",".","pfam15342","FAM212","FAM212 family. This domain family is found in eukaryotes, and is approximately 60 amino acids in length.","GO:0043086|negative regulation of catalytic activity;","GO:0005634|nucleus;GO:0005654|nucleoplasm;","GO:0019901|protein kinase binding;GO:0030291|protein serine/threonine kinase inhibitor activity;",".","."]
["ENSRNOG00000015948",63,4.052817606,265,17.10889281,0.236883687,-2.077749245,{"v":5.46361e-31,"d":"5.46E-31"},{"v":1.20248e-30,"d":"1.20E-30"},"down","yes","Slc1a5","protein_coding","chr1:77456694-77470952:+","gi|149056876|gb|EDM08307.1|",2365,0,"solute carrier family 1 (neutral amino acid transporter), member 5, isoform CRA_a [Rattus norvegicus]","gi|51592103|ref|NM_175758.3|",1536,0,"Rattus norvegicus solute carrier family 1 member 5 (Slc1a5), mRNA","P51912",741,0,"Neutral amino acid transporter B(0)","aq_1330",170,{"v":1e-44,"d":"1.00E-44"},"COG1301","pfam00375","SDF","Sodium:dicarboxylate symporter family.","GO:0006868|glutamine transport;GO:0010585|glutamine secretion;GO:0015825|L-serine transport;GO:0070207|protein homotrimerization;GO:0140009|L-aspartate import across plasma membrane;GO:1903803|L-glutamine import across plasma membrane;","GO:0005886|plasma membrane;GO:0009925|basal plasma membrane;GO:0016021|integral component of membrane;","GO:0015175|neutral amino acid transmembrane transporter activity;GO:0015183|L-aspartate transmembrane transporter activity;GO:0015186|L-glutamine transmembrane transporter activity;GO:0015194|L-serine transmembrane transporter activity;GO:0015293|symporter activity;","K05616","SLC1A5; solute carrier family 1 (neutral amino acid transporter), member 5"]
["ENSRNOG00000003365",28,1.801252269,189,12.20219147,0.147617112,-2.760068122,{"v":8.47171e-31,"d":"8.47E-31"},{"v":1.85951E-30,"d":"1.86E-30"},"down","yes","Cadm3","protein_coding","chr13:85786483-85817749:-","gi|564381901|ref|XP_006250385.1|",2005,0,"PREDICTED: cell adhesion molecule 3 isoform X1 [Rattus norvegicus]","gi|672074947|ref|XM_006250323.2|",2493,0,"PREDICTED: Rattus norvegicus cell adhesion molecule 3 (Cadm3), transcript variant X1, mRNA","Q1WIM3",694,0,"Cell adhesion molecule 3",".",".",".",".","pfam08205","C2-set_2","CD80-like C2-set immunoglobulin domain. These domains belong to the immunoglobulin superfamily.","GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0008104|protein localization;","GO:0005911|cell-cell junction;GO:0016021|integral component of membrane;GO:0098688|parallel fiber to Purkinje cell synapse;GO:0099056|integral component of presynaptic membrane;","GO:0042803|protein homodimerization activity;","K06780","CADM3, IGSF4B, NECL1, TSLL1; cell adhesion molecule 3"]
["ENSRNOG00000020369",260,16.72591393,590,38.0914972,0.439098359,-1.187383951,{"v":1.07505e-30,"d":"1.08E-30"},{"v":2.35518e-30,"d":"2.36E-30"},"down","yes","Igf2","protein_coding","chr1:197814410-197823018:-","gi|297747330|ref|NP_113699.2|",815,{"v":9e-97,"d":"9.00E-97"},"insulin-like growth factor II isoform 1 preproprotein [Rattus norvegicus]","gi|56420|emb|X14834.1|",4542,0,"Rat 4.6 kb mRNA for insulin-like growth factor II","P01346",295,{"v":5e-90,"d":"5.00E-90"},"Insulin-like growth factor II",".",".",".",".","pfam00049","Insulin","Insulin/IGF/Relaxin family. Superfamily includes insulins; relaxins; insulin-like growth factor; and bombyxin. All are secreted regulatory hormones. Disulfide rich, all-alpha fold. Alignment includes B chain, linker (which is processed out of the final product), and A chain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001649|osteoblast differentiation;GO:0001701|in utero embryonic development;GO:0001892|embryonic placenta development;GO:0001934|positive regulation of protein phosphorylation;GO:0006006|glucose metabolic process;GO:0007565|female pregnancy;GO:0007613|memory;GO:0008284|positive regulation of cell proliferation;GO:0009314|response to radiation;GO:0009410|response to xenobiotic stimulus;GO:0009887|animal organ morphogenesis;GO:0014070|response to organic cyclic compound;GO:0031017|exocrine pancreas development;GO:0031056|regulation of histone modification;GO:0031667|response to nutrient levels;GO:0032355|response to estradiol;GO:0035094|response to nicotine;GO:0038028|insulin receptor signaling pathway via phosphatidylinositol 3-kinase;GO:0040018|positive regulation of multicellular organism growth;GO:0042060|wound healing;GO:0042104|positive regulation of activated T cell proliferation;GO:0043085|positive regulation of catalytic activity;GO:0043410|positive regulation of MAPK cascade;GO:0043536|positive regulation of blood vessel endothelial cell migration;GO:0045471|response to ethanol;GO:0045725|positive regulation of glycogen biosynthetic process;GO:0045766|positive regulation of angiogenesis;GO:0045840|positive regulation of mitotic nuclear division;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0045953|negative regulation of natural killer cell mediated cytotoxicity;GO:0046622|positive regulation of organ growth;GO:0046628|positive regulation of insulin receptor signaling pathway;GO:0048633|positive regulation of skeletal muscle tissue growth;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0051146|striated muscle cell differentiation;GO:0051147|regulation of muscle cell differentiation;GO:0051148|negative regulation of muscle cell differentiation;GO:0051781|positive regulation of cell division;GO:0051897|positive regulation of protein kinase B signaling;GO:0060669|embryonic placenta morphogenesis;GO:0060720|spongiotrophoblast cell proliferation;GO:0071260|cellular response to mechanical stimulus;GO:0071902|positive regulation of protein serine/threonine kinase activity;GO:0090031|positive regulation of steroid hormone biosynthetic process;GO:1905564|positive regulation of vascular endothelial cell proliferation;GO:2000467|positive regulation of glycogen (starch) synthase activity;","GO:0005615|extracellular space;GO:0016021|integral component of membrane;","GO:0005158|insulin receptor binding;GO:0005159|insulin-like growth factor receptor binding;GO:0005178|integrin binding;GO:0005179|hormone activity;GO:0005515|protein binding;GO:0008083|growth factor activity;GO:0043539|protein serine/threonine kinase activator activity;GO:0048018|receptor ligand activity;","K13769","IGF2; insulin-like growth factor 2"]
["ENSRNOG00000033153",86,5.532417684,307,19.82049091,0.279126168,-1.84101071,{"v":1.28686E-30,"d":"1.29E-30"},{"v":2.81705e-30,"d":"2.82E-30"},"down","yes","Sfn","protein_coding","chr5:145826201-145831314:-","gi|664721299|ref|XP_008517696.1|",1283,{"v":3e-161,"d":"3.00E-161"},"PREDICTED: 14-3-3 protein sigma [Equus przewalskii]","gi|672019998|ref|XM_001065560.5|",1417,0,"PREDICTED: Rattus norvegicus stratifin (Sfn), mRNA","O70456",475,{"v":3e-155,"d":"3.00E-155"},"14-3-3 protein sigma","YDR099w",293,{"v":6e-89,"d":"6.00E-89"},"COG5040","pfam00244",41701,"14-3-3 protein.","GO:0000079|regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0001836|release of cytochrome c from mitochondria;GO:0003334|keratinocyte development;GO:0007165|signal transduction;GO:0008150|biological_process;GO:0008630|intrinsic apoptotic signaling pathway in response to DNA damage;GO:0010482|regulation of epidermal cell division;GO:0010839|negative regulation of keratinocyte proliferation;GO:0030216|keratinocyte differentiation;GO:0030307|positive regulation of cell growth;GO:0031424|keratinization;GO:0034613|cellular protein localization;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043588|skin development;GO:0045606|positive regulation of epidermal cell differentiation;GO:0046827|positive regulation of protein export from nucleus;GO:0051726|regulation of cell cycle;GO:0061436|establishment of skin barrier;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0003674|molecular_function;GO:0019901|protein kinase binding;GO:0042802|identical protein binding;GO:0051219|phosphoprotein binding;",".","."]
["ENSRNOG00000025948",0,0.032165219,139,8.974098492,0.003584228,-8.124121692,{"v":1.36621E-30,"d":"1.37E-30"},{"v":2.98618e-30,"d":"2.99E-30"},"down","yes","Inava","protein_coding","chr13:47666447-47686729:-","gi|197386162|ref|NP_001127974.1|",2674,0,"uncharacterized protein C1orf106 homolog [Rattus norvegicus]","gi|197386161|ref|NM_001134502.1|",2977,0,"Rattus norvegicus similar to hypothetical protein FLJ10901 (RGD1311892), mRNA","Q7TN12",956,0,"Innate immunity activator protein",".",".",".",".","pfam11819","DUF3338","Domain of unknown function (DUF3338). This family of proteins are functionally uncharacterized. This family is found in eukaryotes. This presumed domain is about 130 amino acids in length.","GO:0002221|pattern recognition receptor signaling pathway;GO:0002720|positive regulation of cytokine production involved in immune response;GO:0031398|positive regulation of protein ubiquitination;GO:0032494|response to peptidoglycan;GO:0032495|response to muramyl dipeptide;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032733|positive regulation of interleukin-10 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032874|positive regulation of stress-activated MAPK cascade;GO:0034334|adherens junction maintenance;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043410|positive regulation of MAPK cascade;GO:0045087|innate immune response;GO:0060729|intestinal epithelial structure maintenance;GO:0070431|nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:1903409|reactive oxygen species biosynthetic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;",".",".","."]
["ENSRNOG00000004141",345,22.19400117,713,46.03260593,0.482136536,-1.052486334,{"v":1.50796E-30,"d":"1.51E-30"},{"v":3.29096e-30,"d":"3.29E-30"},"down","yes","Vasn","protein_coding","chr10:10917605-10928357:-","gi|157820393|ref|NP_001102852.1|",2577,0,"vasorin precursor [Rattus norvegicus]","gi|157820392|ref|NM_001109382.1|",2739,0,"Rattus norvegicus vasorin (Vasn), mRNA","Q9CZT5",941,0,"Vasorin",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.","GO:0010719|negative regulation of epithelial to mesenchymal transition;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0071456|cellular response to hypoxia;GO:0071461|cellular response to redox state;","GO:0005615|extracellular space;GO:0005739|mitochondrion;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0031012|extracellular matrix;GO:0070062|extracellular exosome;","GO:0050431|transforming growth factor beta binding;","K24500","VASN; vasorin"]
["ENSRNOG00000001138",94,6.047061189,321,20.72435695,0.291785227,-1.777021255,{"v":1.677e-30,"d":"1.68E-30"},{"v":3.65567e-30,"d":"3.66E-30"},"down","yes","Taok3","protein_coding","chr12:39314027-39461244:-","gi|66730484|ref|NP_001019425.1|",4113,0,"serine/threonine-protein kinase TAO3 [Rattus norvegicus]","gi|66730483|ref|NM_001024254.1|",1814,0,"Rattus norvegicus TAO kinase 3 (Taok3), mRNA","Q53UA7",1588,0,"Serine/threonine-protein kinase TAO3",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0000165|MAPK cascade;GO:0006281|DNA repair;GO:0006468|protein phosphorylation;GO:0006974|cellular response to DNA damage stimulus;GO:0007095|mitotic G2 DNA damage checkpoint;GO:0032874|positive regulation of stress-activated MAPK cascade;GO:0035556|intracellular signal transduction;GO:0043408|regulation of MAPK cascade;GO:0043507|positive regulation of JUN kinase activity;GO:0046329|negative regulation of JNK cascade;GO:0046330|positive regulation of JNK cascade;GO:0046777|protein autophosphorylation;GO:0048812|neuron projection morphogenesis;","GO:0005737|cytoplasm;","GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;GO:0016740|transferase activity;","K04429","TAO; thousand and one amino acid protein kinase [EC:2.7.11.1]"]
["ENSRNOG00000003069",321,20.65007066,678,43.77294085,0.471754245,-1.083892595,{"v":1.7701e-30,"d":"1.77E-30"},{"v":3.84979e-30,"d":"3.85E-30"},"down","yes","Cd38","protein_coding","chr14:67172063-67211986:-","gi|6978629|ref|NP_037259.1|",1512,0,"ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [Rattus norvegicus]","gi|298900650|emb|FQ212353.1|",2726,0,"Rattus norvegicus TL0AAA57YP13 mRNA sequence","Q64244",587,0,"ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1",".",".",".",".","pfam02267","Rib_hydrolayse","ADP-ribosyl cyclase. ADP-ribosyl cyclase EC:3.2.2.5 (also know as cyclic ADP-ribose hydrolase or CD38) synthesizes cyclic-ADP ribose, a second messenger for glucose-induced insulin secretion.","GO:0001666|response to hypoxia;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007565|female pregnancy;GO:0008284|positive regulation of cell proliferation;GO:0009410|response to xenobiotic stimulus;GO:0009725|response to hormone;GO:0010977|negative regulation of neuron projection development;GO:0014824|artery smooth muscle contraction;GO:0030307|positive regulation of cell growth;GO:0030890|positive regulation of B cell proliferation;GO:0032024|positive regulation of insulin secretion;GO:0032355|response to estradiol;GO:0032526|response to retinoic acid;GO:0032570|response to progesterone;GO:0033194|response to hydroperoxide;GO:0034097|response to cytokine;GO:0043066|negative regulation of apoptotic process;GO:0045779|negative regulation of bone resorption;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045907|positive regulation of vasoconstriction;GO:0050853|B cell receptor signaling pathway;GO:0060292|long-term synaptic depression;GO:0070555|response to interleukin-1;","GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0030667|secretory granule membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0003953|NAD+ nucleosidase activity;GO:0016740|transferase activity;GO:0016798|hydrolase activity, acting on glycosyl bonds;GO:0016849|phosphorus-oxygen lyase activity;GO:0042802|identical protein binding;GO:0050135|NAD(P)+ nucleosidase activity;GO:0061809|NAD+ nucleotidase, cyclic ADP-ribose generating;","K01242","CD38; ADP-ribosyl cyclase 1 [EC:3.2.2.6 2.4.99.20]"]
["ENSRNOG00000003870",90,5.789739437,312,20.14330021,0.28742755,-1.798729742,{"v":3.62435e-30,"d":"3.62E-30"},{"v":7.82897e-30,"d":"7.83E-30"},"down","yes","C1qtnf2","protein_coding","chr10:27941948-27959185:+","gi|300793915|ref|NP_001178847.1|",921,{"v":1E-117,"d":"1.00E-117"},"complement C1q tumor necrosis factor-related protein 2 precursor [Rattus norvegicus]","gi|672067176|ref|XM_006246141.2|",1062,0,"PREDICTED: Rattus norvegicus C1q and tumor necrosis factor related protein 2 (C1qtnf2), transcript variant X1, mRNA","Q9D8U4",357,{"v":2E-118,"d":"2.00E-118"},"Complement C1q tumor necrosis factor-related protein 2",".",".",".",".","pfam00386","C1q","C1q domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.","GO:0019216|regulation of lipid metabolic process;GO:0043410|positive regulation of MAPK cascade;GO:0045725|positive regulation of glycogen biosynthetic process;GO:0046321|positive regulation of fatty acid oxidation;GO:0046326|positive regulation of glucose import;","GO:0005615|extracellular space;GO:0032991|protein-containing complex;","GO:0005102|signaling receptor binding;GO:0042802|identical protein binding;","K24211","C1QTNF2; complement C1q and tumor necrosis factor-related protein 2"]
["ENSRNOG00000003716",58,3.731165415,251,16.20502677,0.230247408,-2.118743178,{"v":3.86412e-30,"d":"3.86E-30"},{"v":8.34374e-30,"d":"8.34E-30"},"down","yes","Batf3","protein_coding","chr13:102689657-102701139:+","gi|11177912|ref|NP_068637.1|",437,{"v":6E-52,"d":"6.00E-52"},"basic leucine zipper transcriptional factor ATF-like 3 [Rattus norvegicus]","gi|672075197|ref|XM_008769873.1|",343,{"v":3e-178,"d":"3.00E-178"},"PREDICTED: Rattus norvegicus basic leucine zipper transcription factor, ATF-like 3 (Batf3), transcript variant X1, mRNA","P97876",172,{"v":2e-53,"d":"2.00E-53"},"Basic leucine zipper transcriptional factor ATF-like 3",".",".",".",".","pfam07716","bZIP_2","Basic region leucine zipper.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;GO:0009615|response to virus;GO:0043011|myeloid dendritic cell differentiation;GO:0097028|dendritic cell differentiation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005829|cytosol;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0044877|protein-containing complex binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09034","BATF; ATF-like basic leucine zipper transcriptional factor"]
["ENSRNOG00000031058",79,5.082104617,291,18.78750116,0.270504554,-1.886275214,{"v":5.01941e-30,"d":"5.02E-30"},{"v":1.08097E-29,"d":"1.08E-29"},"down","yes","ENSRNOG00000031058","protein_coding","chrX:14405124-14413849:+","gi|165971260|gb|AAI58678.1|",1455,0,"Was protein [Rattus norvegicus]","gi|165971259|gb|BC158677.1|",1384,0,"Rattus norvegicus Wiskott-Aldrich syndrome homolog (human), mRNA (cDNA clone MGC:187683 IMAGE:8372629), complete cds","P70315",520,{"v":5E-176,"d":"5.00E-176"},"Wiskott-Aldrich syndrome protein homolog",".",".",".",".","pfam00568","WH1","WH1 domain. WASp Homology domain 1 (WH1) domain. WASP is the protein that is defective in Wiskott-Aldrich syndrome (WAS). The majority of point mutations occur within the amino- terminal WH1 domain. The metabotropic glutamate receptors mGluR1alpha and mGluR5 bind a protein called homer, which is a WH1 domain homologue. A subset of WH1 domains has been termed a \"EVH1\" domain and appear to bind a polyproline motif.","GO:0002625|regulation of T cell antigen processing and presentation;GO:0006955|immune response;GO:0008064|regulation of actin polymerization or depolymerization;GO:0008150|biological_process;GO:0008154|actin polymerization or depolymerization;GO:0010591|regulation of lamellipodium assembly;GO:0016197|endosomal transport;GO:0030041|actin filament polymerization;GO:0030048|actin filament-based movement;GO:0032488|Cdc42 protein signal transduction;GO:0042110|T cell activation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051492|regulation of stress fiber assembly;GO:0051497|negative regulation of stress fiber assembly;GO:0071346|cellular response to interferon-gamma;GO:1905168|positive regulation of double-strand break repair via homologous recombination;GO:2000146|negative regulation of cell motility;GO:2000601|positive regulation of Arp2/3 complex-mediated actin nucleation;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005829|cytosol;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0012506|vesicle membrane;GO:0035861|site of double-strand break;GO:0045335|phagocytic vesicle;","GO:0003674|molecular_function;GO:0003779|actin binding;GO:0017124|SH3 domain binding;GO:0019901|protein kinase binding;GO:0031267|small GTPase binding;GO:0042802|identical protein binding;GO:0043274|phospholipase binding;","K05747","WAS; Wiskott-Aldrich syndrome protein"]
["ENSRNOG00000007422",254,16.3399313,576,37.18763116,0.439391561,-1.186420934,{"v":5.70975e-30,"d":"5.71E-30"},{"v":1.22918E-29,"d":"1.23E-29"},"down","yes","Vav2","protein_coding","chr3:10584688-10754052:-","gi|164663858|ref|NP_001100033.2|",4201,0,"guanine nucleotide exchange factor VAV2 [Rattus norvegicus]","gi|164663857|ref|NM_001106563.2|",5126,0,"Rattus norvegicus vav guanine nucleotide exchange factor 2 (Vav2), mRNA","Q60992",1601,0,"Guanine nucleotide exchange factor VAV2",".",".",".",".","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0007264|small GTPase mediated signal transduction;GO:0008361|regulation of cell size;GO:0016477|cell migration;GO:0030031|cell projection assembly;GO:0030032|lamellipodium assembly;GO:0043087|regulation of GTPase activity;GO:0043552|positive regulation of phosphatidylinositol 3-kinase activity;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;","GO:0001784|phosphotyrosine residue binding;GO:0005085|guanyl-nucleotide exchange factor activity;GO:0005154|epidermal growth factor receptor binding;GO:0046872|metal ion binding;","K05730","VAV; guanine nucleotide exchange factor VAV"]
["ENSRNOG00000019862",1,0.064330438,122,7.876546878,0.00816734,-6.935917957,{"v":1.34109e-29,"d":"1.34E-29"},{"v":2.86439e-29,"d":"2.86E-29"},"down","yes","Pinlyp","protein_coding","chr1:80134643-80139996:-","gi|157819179|ref|NP_001100958.1|",1014,{"v":5E-137,"d":"5.00E-137"},"phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein precursor [Rattus norvegicus]","gi|157819178|ref|NM_001107488.1|",734,0,"Rattus norvegicus phospholipase A2 inhibitor and LY6/PLAUR domain containing (Pinlyp), mRNA","Q9CQD7",377,{"v":2E-131,"d":"2.00E-131"},"phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein",".",".",".",".","pfam00021","UPAR_LY6","u-PAR/Ly-6 domain. This extracellular disulphide bond rich domain is related to pfam00087.","GO:0043086|negative regulation of catalytic activity;","GO:0005576|extracellular region;","GO:0004859|phospholipase inhibitor activity;",".","."]
["ENSRNOG00000000528",182,11.70813975,463,29.89214102,0.39167953,-1.352254362,{"v":1.43071e-29,"d":"1.43E-29"},{"v":3.05467E-29,"d":"3.05E-29"},"down","yes","Fgd2","protein_coding","chr20:7424790-7441603:+","gi|564397249|ref|XP_006256267.1|",3436,0,"PREDICTED: FYVE, RhoGEF and PH domain-containing protein 2 isoform X1 [Rattus norvegicus]","gi|672085676|ref|XM_006256205.2|",2784,0,"PREDICTED: Rattus norvegicus FYVE, RhoGEF and PH domain containing 2 (Fgd2), transcript variant X1, mRNA","Q8BY35",1247,0,"FYVE, RhoGEF and PH domain-containing protein 2",".",".",".",".","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0007010|cytoskeleton organization;GO:0043507|positive regulation of JUN kinase activity;GO:0046847|filopodium assembly;","GO:0001726|ruffle;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005769|early endosome;GO:0005856|cytoskeleton;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0046872|metal ion binding;GO:1901981|phosphatidylinositol phosphate binding;","K05721","FGD2; FYVE, RhoGEF and PH domain containing 2"]
["ENSRNOG00000062621",4,0.257321753,120,7.747423159,0.03321385,-4.912071215,{"v":1.86639E-29,"d":"1.87E-29"},{"v":3.97448e-29,"d":"3.97E-29"},"down","yes","Ly49i7","protein_coding","chr4:164853574-164867333:-","gi|57222326|ref|NP_001009500.1|",1377,0,"immunoreceptor Ly49i7 [Rattus norvegicus]","gi|672051553|ref|XM_008763440.1|",819,0,"PREDICTED: Rattus norvegicus killer cell lectin-like receptor 5-like (LOC100911272), mRNA","P20937",325,{"v":8e-110,"d":"8.00E-110"},"T-cell surface glycoprotein YE1/48",".",".",".",".","pfam08391","Ly49","Ly49-like protein, N-terminal region. The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).",".",".",".",".","."]
["ENSRNOG00000065402",67,4.310139358,265,17.10889281,0.251923921,-1.988939978,{"v":2.24096e-29,"d":"2.24E-29"},{"v":4.75793e-29,"d":"4.76E-29"},"down","yes","ENSRNOG00000065402","lncRNA","chr2:235885302-235887993:-",".",".",".",".","gi|672044449|ref|XM_006233472.2|",2692,0,"PREDICTED: Rattus norvegicus tubulin tyrosine ligase-like family, member 7 (Ttll7), transcript variant X8, mRNA",".",".",".",".",".",".",".",".","pfam13764","E3_UbLigase_R4","E3 ubiquitin-protein ligase UBR4. This is a family of E## ubiquitin ligase enzymes.",".",".",".",".","."]
["ENSRNOG00000042975",243,15.63229648,555,35.83183211,0.436268412,-1.196712077,{"v":2.5831e-29,"d":"2.58E-29"},{"v":5.47417e-29,"d":"5.47E-29"},"down","yes","Tmem45al","protein_coding","chr11:43713782-43799526:+","gi|300797305|ref|NP_001178003.1|",1334,{"v":5e-180,"d":"5.00E-180"},"transmembrane protein 45A [Rattus norvegicus]","gi|672070962|ref|XM_003751037.3|",1581,0,"PREDICTED: Rattus norvegicus transmembrane protein 45A-like (Tmem45al), transcript variant X3, mRNA","Q60774",446,{"v":3E-153,"d":"3.00E-153"},"Transmembrane protein 45A",".",".",".",".","pfam04819","DUF716","Family of unknown function (DUF716). This family is equally distributed in both metazoa and plants. Annotation associated with a member from Nicotiana tabacum suggest that it may be involved in response to viral attack in plants. However, no clear function has been assigned to this family.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000002794",86,5.532417684,300,19.3685579,0.285639112,-1.807734555,{"v":2.92792e-29,"d":"2.93E-29"},{"v":6.19573e-29,"d":"6.20E-29"},"down","yes","Selp","protein_coding","chr13:76476295-76511845:+","gi|564381444|ref|XP_006250212.1|",3913,0,"PREDICTED: P-selectin isoform X1 [Rattus norvegicus]","gi|672074304|ref|XM_006250150.2|",3239,0,"PREDICTED: Rattus norvegicus selectin P (Selp), transcript variant X1, mRNA","P98106",1503,0,"P-selectin",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0002687|positive regulation of leukocyte migration;GO:0002691|regulation of cellular extravasation;GO:0006954|inflammatory response;GO:0007155|cell adhesion;GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007159|leukocyte cell-cell adhesion;GO:0010572|positive regulation of platelet activation;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0014070|response to organic cyclic compound;GO:0016339|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0032496|response to lipopolysaccharide;GO:0033623|regulation of integrin activation;GO:0034097|response to cytokine;GO:0035584|calcium-mediated signaling using intracellular calcium source;GO:0045785|positive regulation of cell adhesion;GO:0050900|leukocyte migration;GO:0050901|leukocyte tethering or rolling;GO:0098609|cell-cell adhesion;GO:1903238|positive regulation of leukocyte tethering or rolling;","GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0031092|platelet alpha granule membrane;","GO:0001530|lipopolysaccharide binding;GO:0005509|calcium ion binding;GO:0008201|heparin binding;GO:0030246|carbohydrate binding;GO:0033691|sialic acid binding;GO:0042806|fucose binding;GO:0046872|metal ion binding;GO:0048306|calcium-dependent protein binding;GO:0070492|oligosaccharide binding;","K06496","SELP, CD62P; selectin, platelet"]
["ENSRNOG00000011582",254,16.3399313,570,36.80026,0.444016735,-1.171314042,{"v":4.13878e-29,"d":"4.14E-29"},{"v":8.71603e-29,"d":"8.72E-29"},"down","yes","Rab3d","protein_coding","chr8:20439294-20449185:-","gi|564362525|ref|XP_006242655.1|",1113,{"v":3e-141,"d":"3.00E-141"},"PREDICTED: GTP-binding protein Rab-3D isoform X2 [Rattus norvegicus]","gi|54262181|ref|NM_080580.2|",2206,0,"Rattus norvegicus RAB3D, member RAS oncogene family (Rab3d), mRNA","Q63942",426,{"v":3e-140,"d":"3.00E-140"},"GTP-binding protein Rab-3D",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0006904|vesicle docking involved in exocytosis;GO:0009306|protein secretion;GO:0017157|regulation of exocytosis;GO:0018125|peptidyl-cysteine methylation;GO:0045453|bone resorption;GO:0072659|protein localization to plasma membrane;GO:1903307|positive regulation of regulated secretory pathway;","GO:0005768|endosome;GO:0005881|cytoplasmic microtubule;GO:0005886|plasma membrane;GO:0008021|synaptic vesicle;GO:0030133|transport vesicle;GO:0042588|zymogen granule;GO:0099503|secretory vesicle;","GO:0003924|GTPase activity;GO:0005515|protein binding;GO:0005525|GTP binding;GO:0030742|GTP-dependent protein binding;GO:0031489|myosin V binding;","K07884","RAB3D; Ras-related protein Rab-3D"]
["ENSRNOG00000028216",6,0.385982629,124,8.005670597,0.048213654,-4.374414429,{"v":4.19002e-29,"d":"4.19E-29"},{"v":8.82067e-29,"d":"8.82E-29"},"down","yes","Igsf5","protein_coding","chr11:35686705-35741129:+","gi|55741625|ref|NP_001006991.1|",1773,0,"immunoglobulin superfamily member 5 precursor [Rattus norvegicus]","gi|67514578|ref|NM_001006990.2|",2128,0,"Rattus norvegicus immunoglobulin superfamily, member 5 (Igsf5), mRNA","Q5VJ70",687,0,"Immunoglobulin superfamily member 5",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0098609|cell-cell adhesion;","GO:0005923|bicellular tight junction;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;","GO:0030165|PDZ domain binding;","K06786","JAM4, JCAM; junctional adhesion molecule 4"]
["ENSRNOG00000010522",44,2.83053928,217,14.00992355,0.202038168,-2.307300233,{"v":5.17974e-29,"d":"5.18E-29"},{"v":1.08881e-28,"d":"1.09E-28"},"down","yes","Tlr4","protein_coding","chr5:80145826-80159628:+","gi|149059567|gb|EDM10505.1|",4145,0,"toll-like receptor 4 [Rattus norvegicus]","gi|240147721|gb|GQ175880.1|",3327,0,"Rattus norvegicus toll-like receptor 4 (Tlr4) mRNA, complete cds","Q9QX05",1595,0,"Toll-like receptor 4",".",".",".",".","pfam01582","TIR","TIR domain. The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.","GO:0001666|response to hypoxia;GO:0001774|microglial cell activation;GO:0002218|activation of innate immune response;GO:0002224|toll-like receptor signaling pathway;GO:0002246|wound healing involved in inflammatory response;GO:0002322|B cell proliferation involved in immune response;GO:0002537|nitric oxide production involved in inflammatory response;GO:0002730|regulation of dendritic cell cytokine production;GO:0002755|MyD88-dependent toll-like receptor signaling pathway;GO:0002758|innate immune response-activating signal transduction;GO:0003009|skeletal muscle contraction;GO:0006691|leukotriene metabolic process;GO:0006909|phagocytosis;GO:0006954|inflammatory response;GO:0006979|response to oxidative stress;GO:0007252|I-kappaB phosphorylation;GO:0009617|response to bacterium;GO:0009636|response to toxic substance;GO:0010572|positive regulation of platelet activation;GO:0010628|positive regulation of gene expression;GO:0014002|astrocyte development;GO:0014823|response to activity;GO:0014911|positive regulation of smooth muscle cell migration;GO:0016064|immunoglobulin mediated immune response;GO:0030890|positive regulation of B cell proliferation;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0032496|response to lipopolysaccharide;GO:0032497|detection of lipopolysaccharide;GO:0032526|response to retinoic acid;GO:0032570|response to progesterone;GO:0032680|regulation of tumor necrosis factor production;GO:0032689|negative regulation of interferon-gamma production;GO:0032700|negative regulation of interleukin-17 production;GO:0032707|negative regulation of interleukin-23 production;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032722|positive regulation of chemokine production;GO:0032727|positive regulation of interferon-alpha production;GO:0032728|positive regulation of interferon-beta production;GO:0032729|positive regulation of interferon-gamma production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032732|positive regulation of interleukin-1 production;GO:0032733|positive regulation of interleukin-10 production;GO:0032735|positive regulation of interleukin-12 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032868|response to insulin;GO:0032874|positive regulation of stress-activated MAPK cascade;GO:0034142|toll-like receptor 4 signaling pathway;GO:0035666|TRIF-dependent toll-like receptor signaling pathway;GO:0036120|cellular response to platelet-derived growth factor stimulus;GO:0042116|macrophage activation;GO:0042742|defense response to bacterium;GO:0043032|positive regulation of macrophage activation;GO:0043065|positive regulation of apoptotic process;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043278|response to morphine;GO:0043388|positive regulation of DNA binding;GO:0043406|positive regulation of MAP kinase activity;GO:0045348|positive regulation of MHC class II biosynthetic process;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0045471|response to ethanol;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046330|positive regulation of JNK cascade;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0050671|positive regulation of lymphocyte proliferation;GO:0050727|regulation of inflammatory response;GO:0050729|positive regulation of inflammatory response;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050829|defense response to Gram-negative bacterium;GO:0050965|detection of temperature stimulus involved in sensory perception of pain;GO:0050966|detection of mechanical stimulus involved in sensory perception of pain;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051384|response to glucocorticoid;GO:0051770|positive regulation of nitric-oxide synthase biosynthetic process;GO:0051930|regulation of sensory perception of pain;GO:0060729|intestinal epithelial structure maintenance;GO:0060907|positive regulation of macrophage cytokine production;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070430|positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway;GO:0070434|positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0070542|response to fatty acid;GO:0071222|cellular response to lipopolysaccharide;GO:0071223|cellular response to lipoteichoic acid;GO:0071260|cellular response to mechanical stimulus;GO:0071300|cellular response to retinoic acid;GO:0071346|cellular response to interferon-gamma;GO:0120163|negative regulation of cold-induced thermogenesis;GO:0140052|cellular response to oxidised low-density lipoprotein particle stimulus;GO:1900017|positive regulation of cytokine production involved in inflammatory response;GO:1900227|positive regulation of NLRP3 inflammasome complex assembly;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1903223|positive regulation of oxidative stress-induced neuron death;GO:1903428|positive regulation of reactive oxygen species biosynthetic process;GO:1903974|positive regulation of cellular response to macrophage colony-stimulating factor stimulus;GO:1904466|positive regulation of matrix metallopeptidase secretion;GO:1904646|cellular response to amyloid-beta;GO:1990268|response to gold nanoparticle;GO:2000343|positive regulation of chemokine (C-X-C motif) ligand 2 production;","GO:0001726|ruffle;GO:0001891|phagocytic cup;GO:0005737|cytoplasm;GO:0005769|early endosome;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0031226|intrinsic component of plasma membrane;GO:0043235|receptor complex;GO:0045121|membrane raft;GO:0046696|lipopolysaccharide receptor complex;GO:0048471|perinuclear region of cytoplasm;","GO:0001530|lipopolysaccharide binding;GO:0001875|lipopolysaccharide receptor activity;GO:0003953|NAD+ nucleosidase activity;GO:0004888|transmembrane signaling receptor activity;GO:0005102|signaling receptor binding;GO:0005515|protein binding;GO:0038023|signaling receptor activity;GO:0042802|identical protein binding;GO:0043548|phosphatidylinositol 3-kinase binding;GO:0046982|protein heterodimerization activity;GO:0050135|NAD(P)+ nucleosidase activity;GO:0061809|NAD+ nucleotidase, cyclic ADP-ribose generating;","K10160","TLR4, CD284; toll-like receptor 4"]
["ENSRNOG00000033912",45,2.894869718,219,14.13904726,0.204742913,-2.288114583,{"v":5.47345e-29,"d":"5.47E-29"},{"v":1.14971e-28,"d":"1.15E-28"},"down","yes","Fcho1","protein_coding","chr16:18413363-18435104:-","gi|672079582|ref|XP_008769304.1|",4154,0,"PREDICTED: FCH domain only protein 1 isoform X1 [Rattus norvegicus]","gi|672079581|ref|XM_008771082.1|",2875,0,"PREDICTED: Rattus norvegicus FCH domain only 1 (Fcho1), transcript variant X1, mRNA","Q8K285",1484,0,"F-BAR domain only protein 1",".",".",".",".","pfam10291","muHD","Muniscin C-terminal mu homology domain. The muniscins are a family of endocytic adaptors that is conserved from yeast to humans.This C-terminal domain is structurally similar to mu homology domains, and is the region of the muniscin proteins involved in the interactions with the endocytic adaptor-scaffold proteins Ede1-eps15. This interaction influences muniscin localisation. The muniscins provide a combined adaptor-membrane-tubulation activity that is important for regulating endocytosis.","GO:0048268|clathrin coat assembly;GO:0072583|clathrin-dependent endocytosis;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005905|clathrin-coated pit;GO:0030136|clathrin-coated vesicle;","GO:0035612|AP-2 adaptor complex binding;","K20042","FCHO; F-BAR domain only protein"]
["ENSRNOG00000003785",156,10.03554836,417,26.92229548,0.372759758,-1.423681974,{"v":7.65684e-29,"d":"7.66E-29"},{"v":1.60185e-28,"d":"1.60E-28"},"down","yes","Usp43","protein_coding","chr10:52548963-52611533:-","gi|123314452|ref|NP_776115.2|",4860,0,"ubiquitin carboxyl-terminal hydrolase 43 isoform 1 [Mus musculus]","gi|123314451|ref|NM_173754.4|",3120,0,"Mus musculus ubiquitin specific peptidase 43 (Usp43), transcript variant 1, mRNA","Q8BUM9",1876,0,"Ubiquitin carboxyl-terminal hydrolase 43","SPCC1494.05c",131,{"v":7e-30,"d":"7.00E-30"},"COG5560","pfam00443","UCH","Ubiquitin carboxyl-terminal hydrolase.","GO:0006511|ubiquitin-dependent protein catabolic process;GO:0016579|protein deubiquitination;",".","GO:0004843|thiol-dependent ubiquitin-specific protease activity;","K11856","USP43; ubiquitin carboxyl-terminal hydrolase 43 [EC:3.4.19.12]"]
["ENSRNOG00000049537",121,7.78398302,359,23.17770762,0.33583921,-1.574157416,{"v":8.13597e-29,"d":"8.14E-29"},{"v":1.70022E-28,"d":"1.70E-28"},"down","yes","ENSRNOG00000049537","protein_coding","chr13:72274552-72312103:+","gi|149058287|gb|EDM09444.1|",784,{"v":1e-93,"d":"1.00E-93"},"rCG46225, isoform CRA_a [Rattus norvegicus]","gi|242332507|ref|NM_001162898.1|",3854,0,"Rattus norvegicus hypothetical protein LOC100302372 (LOC100302372), mRNA",".",".",".",".",".",".",".",".","pfam03154","Atrophin-1","Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.",".",".",".",".","."]
["ENSRNOG00000067966",230,14.79600078,530,34.21778562,0.43240673,-1.209539118,{"v":1.61554e-28,"d":"1.62E-28"},{"v":3.3601e-28,"d":"3.36E-28"},"down","yes","Ly96","protein_coding","chr5:2582254-2612386:-","gi|66730493|ref|NP_001019450.1|",737,{"v":2e-94,"d":"2.00E-94"},"lymphocyte antigen 96 precursor [Rattus norvegicus]","gi|298898207|emb|FQ234779.1|",940,0,"Rattus norvegicus TL0AEA57YL02 mRNA sequence","Q9JHF9",266,{"v":2E-87,"d":"2.00E-87"},"Lymphocyte antigen 96",".",".",".",".","pfam02221","E1_DerP2_DerF2","ML domain. ML domain - MD-2-related lipid recognition domain. This family consists of proteins from plants, animals and fungi, including dust mite allergen Der P 2. It has been implicate in lipid recognition, particularly in the recognition of pathogen related products. A mutation in Npc2 causes a rare form of Niemann-Pick type C2 disease. This domain has a similar topology to immunoglobulin domains.",".",".",".",".","."]
["ENSRNOG00000031779",3,0.192991315,114,7.360052001,0.026221461,-5.253108133,{"v":1.71146E-28,"d":"1.71E-28"},{"v":3.55831e-28,"d":"3.56E-28"},"down","yes","Ltf","protein_coding","chr8:110999948-111022795:+","gi|157819071|ref|NP_001100334.1|",3755,0,"lactotransferrin precursor [Rattus norvegicus]","gi|157819070|ref|NM_001106864.1|",2761,0,"Rattus norvegicus lactotransferrin (Ltf), mRNA","P08071",1012,0,"Lactotransferrin",".",".",".",".","pfam00405","Transferrin","Transferrin.","GO:0001817|regulation of cytokine production;GO:0001895|retina homeostasis;GO:0002227|innate immune response in mucosa;GO:0006508|proteolysis;GO:0006826|iron ion transport;GO:0008150|biological_process;GO:0019731|antibacterial humoral response;GO:0019732|antifungal humoral response;GO:0031640|killing of cells of other organism;GO:0031665|negative regulation of lipopolysaccharide-mediated signaling pathway;GO:0032680|regulation of tumor necrosis factor production;GO:0032780|negative regulation of ATPase activity;GO:0033690|positive regulation of osteoblast proliferation;GO:0034145|positive regulation of toll-like receptor 4 signaling pathway;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0044793|negative regulation by host of viral process;GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0045669|positive regulation of osteoblast differentiation;GO:0045837|negative regulation of membrane potential;GO:0048525|negative regulation of viral process;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051673|membrane disruption in other organism;GO:0060349|bone morphogenesis;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0071902|positive regulation of protein serine/threonine kinase activity;GO:1900229|negative regulation of single-species biofilm formation in or on host organism;GO:1902732|positive regulation of chondrocyte proliferation;GO:2000117|negative regulation of cysteine-type endopeptidase activity;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005769|early endosome;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0030141|secretory granule;GO:0032991|protein-containing complex;GO:0042581|specific granule;GO:0055037|recycling endosome;","GO:0001530|lipopolysaccharide binding;GO:0003674|molecular_function;GO:0004869|cysteine-type endopeptidase inhibitor activity;GO:0005506|iron ion binding;GO:0008201|heparin binding;GO:0008233|peptidase activity;GO:0043539|protein serine/threonine kinase activator activity;","K17283","LTF; lactotransferrin [EC:3.4.21.-]"]
["ENSRNOG00000054515",226,14.53867903,523,33.7658526,0.430573432,-1.215668793,{"v":2.24168e-28,"d":"2.24E-28"},{"v":4.65392e-28,"d":"4.65E-28"},"down","yes","Fgd6","protein_coding","chr7:28597609-28712456:+","gi|212549635|ref|NP_001131117.1|",6451,0,"FYVE, RhoGEF and PH domain-containing protein 6 [Rattus norvegicus]","gi|212549634|ref|NM_001137645.1|",4343,0,"Rattus norvegicus FYVE, RhoGEF and PH domain containing 6 (Fgd6), mRNA","Q69ZL1",2078,0,"FYVE, RhoGEF and PH domain-containing protein 6",".",".",".",".","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0043087|regulation of GTPase activity;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0046872|metal ion binding;","K05724","FGD5_6; FYVE, RhoGEF and PH domain containing 5/6"]
["ENSRNOG00000052499",236,15.18198341,538,34.73428049,0.437089331,-1.193999933,{"v":2.26707E-28,"d":"2.27E-28"},{"v":4.70321e-28,"d":"4.70E-28"},"down","yes","Rab27a","protein_coding","chr8:73782694-73847829:+","gi|8394142|ref|NP_059013.1|",1190,{"v":4e-154,"d":"4.00E-154"},"ras-related protein Rab-27A [Rattus norvegicus]","gi|70778972|ref|NM_017317.2|",2662,0,"Rattus norvegicus RAB27A, member RAS oncogene family (Rab27a), mRNA","P23640",462,{"v":1E-155,"d":"1.00E-155"},"Ras-related protein Rab-27A",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0006605|protein targeting;GO:0006887|exocytosis;GO:0007596|blood coagulation;GO:0010628|positive regulation of gene expression;GO:0016192|vesicle-mediated transport;GO:0019882|antigen processing and presentation;GO:0030318|melanocyte differentiation;GO:0032400|melanosome localization;GO:0032402|melanosome transport;GO:0036257|multivesicular body organization;GO:0043316|cytotoxic T cell degranulation;GO:0043320|natural killer cell degranulation;GO:0043473|pigmentation;GO:0045921|positive regulation of exocytosis;GO:0050766|positive regulation of phagocytosis;GO:0051875|pigment granule localization;GO:0051904|pigment granule transport;GO:0071985|multivesicular body sorting pathway;GO:0097278|complement-dependent cytotoxicity;GO:1903307|positive regulation of regulated secretory pathway;GO:1903428|positive regulation of reactive oxygen species biosynthetic process;GO:1903435|positive regulation of constitutive secretory pathway;GO:1990182|exosomal secretion;","GO:0001750|photoreceptor outer segment;GO:0005764|lysosome;GO:0005770|late endosome;GO:0005794|Golgi apparatus;GO:0016324|apical plasma membrane;GO:0030141|secretory granule;GO:0030425|dendrite;GO:0030667|secretory granule membrane;GO:0032585|multivesicular body membrane;GO:0033093|Weibel-Palade body;GO:0042470|melanosome;GO:0070382|exocytic vesicle;","GO:0003924|GTPase activity;GO:0005515|protein binding;GO:0005525|GTP binding;GO:0019003|GDP binding;GO:0019904|protein domain specific binding;GO:0031489|myosin V binding;","K07885","RAB27A; Ras-related protein Rab-27A"]
["ENSRNOG00000017625",36,2.315895775,196,12.65412449,0.183015093,-2.449965462,{"v":3.59333e-28,"d":"3.59E-28"},{"v":7.41691e-28,"d":"7.42E-28"},"down","yes","Htr2b","protein_coding","chr9:86742102-86755108:-","gi|672065531|ref|XP_008765438.1|",2400,0,"PREDICTED: 5-hydroxytryptamine receptor 2B isoform X1 [Rattus norvegicus]","gi|672065530|ref|XM_008767216.1|",1971,0,"PREDICTED: Rattus norvegicus 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled (Htr2b), transcript variant X1, mRNA","P30994",922,0,"5-hydroxytryptamine receptor 2B",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001755|neural crest cell migration;GO:0001819|positive regulation of cytokine production;GO:0001938|positive regulation of endothelial cell proliferation;GO:0002031|G protein-coupled receptor internalization;GO:0003007|heart morphogenesis;GO:0003300|cardiac muscle hypertrophy;GO:0006874|cellular calcium ion homeostasis;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007187|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007202|activation of phospholipase C activity;GO:0007205|protein kinase C-activating G protein-coupled receptor signaling pathway;GO:0007208|phospholipase C-activating serotonin receptor signaling pathway;GO:0007268|chemical synaptic transmission;GO:0007507|heart development;GO:0008284|positive regulation of cell proliferation;GO:0009410|response to xenobiotic stimulus;GO:0010507|negative regulation of autophagy;GO:0010513|positive regulation of phosphatidylinositol biosynthetic process;GO:0014033|neural crest cell differentiation;GO:0014065|phosphatidylinositol 3-kinase signaling;GO:0014827|intestine smooth muscle contraction;GO:0016310|phosphorylation;GO:0019722|calcium-mediated signaling;GO:0019934|cGMP-mediated signaling;GO:0034220|ion transmembrane transport;GO:0035733|hepatic stellate cell activation;GO:0042310|vasoconstriction;GO:0043066|negative regulation of apoptotic process;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043406|positive regulation of MAP kinase activity;GO:0043647|inositol phosphate metabolic process;GO:0048598|embryonic morphogenesis;GO:0050795|regulation of behavior;GO:0051000|positive regulation of nitric-oxide synthase activity;GO:0051209|release of sequestered calcium ion into cytosol;GO:0051781|positive regulation of cell division;GO:0060548|negative regulation of cell death;GO:0070371|ERK1 and ERK2 cascade;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070528|protein kinase C signaling;GO:0071418|cellular response to amine stimulus;GO:0071502|cellular response to temperature stimulus;GO:0098664|G protein-coupled serotonin receptor signaling pathway;GO:1904015|cellular response to serotonin;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0030425|dendrite;GO:0043025|neuronal cell body;GO:0045202|synapse;GO:0098666|G protein-coupled serotonin receptor complex;","GO:0001587|Gq/11-coupled serotonin receptor activity;GO:0001965|G-protein alpha-subunit binding;GO:0004993|G protein-coupled serotonin receptor activity;GO:0005096|GTPase activator activity;GO:0005515|protein binding;GO:0030594|neurotransmitter receptor activity;GO:0051378|serotonin binding;","K04157","HTR2; 5-hydroxytryptamine receptor 2"]
["ENSRNOG00000012083",26,1.672591393,173,11.16920172,0.149750308,-2.739369129,{"v":4.01434e-28,"d":"4.01E-28"},{"v":8.27994e-28,"d":"8.28E-28"},"down","yes","St6galnac2","protein_coding","chr10:101910222-101927933:-","gi|72535132|ref|NP_001026822.1|",1747,0,"alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 [Rattus norvegicus]","gi|72535131|ref|NM_001031652.1|",1842,0,"Rattus norvegicus ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 (St6galnac2), mRNA","P70277",629,0,"Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2",".",".",".",".","pfam00777","Glyco_transf_29","Glycosyltransferase family 29 (sialyltransferase). Members of this family belong to glycosyltransferase family 29.","GO:0006486|protein glycosylation;GO:0006493|protein O-linked glycosylation;GO:1990743|protein sialylation;","GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;","GO:0001665|alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity;","K06616","SIAT7B, ST6GalNAc II; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7B) [EC:2.4.99.3]"]
["ENSRNOG00000070099",39,2.508887089,202,13.04149565,0.192377252,-2.377989883,{"v":4.73769e-28,"d":"4.74E-28"},{"v":9.74727e-28,"d":"9.75E-28"},"down","yes","Crb3","protein_coding","chr9:1896623-1903859:+","gi|564366823|ref|XP_006244365.1|",519,{"v":2e-62,"d":"2.00E-62"},"PREDICTED: protein crumbs homolog 3 isoform X1 [Rattus norvegicus]","gi|298889082|emb|FQ223867.1|",955,0,"Rattus norvegicus TL0ACA84YK03 mRNA sequence","Q8QZT4",128,{"v":1e-34,"d":"1.00E-34"},"Protein crumbs homolog 3",".",".",".",".","pfam14610","DUF4448","Protein of unknown function (DUF4448). This is a family of predicted membrane glycoproteins from fungi. However there appears, visually, to be some similarity with the family of GPI-anchored fungal proteins, pfam10342.",".",".",".",".","."]
["ENSRNOG00000010646",86,5.532417684,293,18.91662488,0.292463255,-1.773672719,{"v":6.43731e-28,"d":"6.44E-28"},{"v":1.32155E-27,"d":"1.32E-27"},"down","yes","Tmem229b","protein_coding","chr6:97775332-97819489:-","gi|564356481|ref|XP_006240337.1|",940,{"v":2E-113,"d":"2.00E-113"},"PREDICTED: transmembrane protein 229B isoform X2 [Rattus norvegicus]","gi|157819610|ref|NM_001109359.1|",3515,0,"Rattus norvegicus transmembrane protein 229B (Tmem229b), mRNA","Q8BFQ2",346,{"v":2e-108,"d":"2.00E-108"},"Transmembrane protein 229B",".",".",".",".","pfam06541","DUF1113","Protein of unknown function (DUF1113). This family consists of several bacterial proteins of unknown function.","GO:0009617|response to bacterium;","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000004281",24,1.543930516,166,10.7172687,0.144060073,-2.79525755,{"v":1.36463E-27,"d":"1.36E-27"},{"v":2.78551e-27,"d":"2.79E-27"},"down","yes","Cobl","protein_coding","chr14:86828139-87060800:-","gi|672076787|ref|XP_008768533.1|",6146,0,"PREDICTED: protein cordon-bleu isoform X4 [Rattus norvegicus]","gi|672076786|ref|XM_008770311.1|",3155,0,"PREDICTED: Rattus norvegicus cordon-bleu WH2 repeat protein (Cobl), transcript variant X4, mRNA","Q5NBX1",2063,0,"Protein cordon-bleu",".",".",".",".","pfam09469","Cobl","Cordon-bleu ubiquitin-like domain. The Cordon-bleu protein domain is highly conserved among vertebrates. The sequence contains three repeated lysine, arginine, and proline-rich regions, the KKRAP motif. The exact function of the protein is unknown but it is thought to be involved in mid-brain neural tube closure. It is expressed specifically in the node. This domain has a ubiquitin-like fold.","GO:0000578|embryonic axis specification;GO:0001757|somite specification;GO:0001843|neural tube closure;GO:0001889|liver development;GO:0030036|actin cytoskeleton organization;GO:0030041|actin filament polymerization;GO:0030903|notochord development;GO:0033504|floor plate development;GO:0048565|digestive tract development;GO:0048669|collateral sprouting in absence of injury;GO:0051639|actin filament network formation;GO:1900006|positive regulation of dendrite development;GO:1900029|positive regulation of ruffle assembly;","GO:0001726|ruffle;GO:0005829|cytosol;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0005938|cell cortex;GO:0016020|membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0043025|neuronal cell body;GO:0044294|dendritic growth cone;GO:0044295|axonal growth cone;GO:0048471|perinuclear region of cytoplasm;GO:1990357|terminal web;","GO:0003785|actin monomer binding;GO:0005515|protein binding;","K18623","COBL; protein cordon-bleu"]
["ENSRNOG00000033693",6,0.385982629,118,7.618299439,0.050665195,-4.302861168,{"v":1.45632E-27,"d":"1.46E-27"},{"v":2.96947e-27,"d":"2.97E-27"},"down","yes","AC135826.1","protein_coding","chr2:31507424-31570542:-","gi|564299708|ref|XP_006224055.1|",7483,0,"PREDICTED: baculoviral IAP repeat-containing protein 1b [Rattus norvegicus]","gi|672041330|ref|XM_008760697.1|",3876,0,"PREDICTED: Rattus norvegicus NLR family, apoptosis inhibitory protein 6 (Naip6), transcript variant X5, mRNA","Q9QUK4",2503,0,"Baculoviral IAP repeat-containing protein 1b",".",".",".",".","pfam05729","NACHT","NACHT domain. This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.",".",".",".",".","."]
["ENSRNOG00000049282",8,0.514643505,123,7.941108738,0.064807513,-3.947695125,{"v":2.30228e-27,"d":"2.30E-27"},{"v":4.67437e-27,"d":"4.67E-27"},"down","yes","Oas2","protein_coding","chr12:35806759-35829371:+","gi|57527617|ref|NP_001009715.1|",3782,0,"2'-5'-oligoadenylate synthase 2 [Rattus norvegicus]","gi|37921529|gb|AY230746.1|",2308,0,"Rattus norvegicus 2'-5' oligoadenylate synthetase 2 (Oas2) mRNA, complete cds","Q5MYU0",1461,0,"2'-5'-oligoadenylate synthase 2",".",".",".",".","pfam10421","OAS1_C","2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus. This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between 320 and 344 at the extreme C-terminal end. Oligoadenylate synthetases are antiviral enzymes that counteract vial attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesize 2'.5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication. This domain is often associated with NTP_transf_2 pfam01909.","GO:0006401|RNA catabolic process;GO:0009615|response to virus;GO:0009617|response to bacterium;GO:0032728|positive regulation of interferon-beta production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0042742|defense response to bacterium;GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0051607|defense response to virus;GO:0060337|type I interferon signaling pathway;GO:0060700|regulation of ribonuclease activity;GO:0070106|interleukin-27-mediated signaling pathway;GO:1903487|regulation of lactation;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016020|membrane;GO:0048471|perinuclear region of cytoplasm;","GO:0001730|2'-5'-oligoadenylate synthetase activity;GO:0003725|double-stranded RNA binding;GO:0005524|ATP binding;GO:0046872|metal ion binding;","K14216","OAS; 2'-5'-oligoadenylate synthetase [EC:2.7.7.84]"]
["ENSRNOG00000009342",6,0.385982629,117,7.55373758,0.051098231,-4.290582838,{"v":2.63233e-27,"d":"2.63E-27"},{"v":5.3388e-27,"d":"5.34E-27"},"down","yes","Fcnb","protein_coding","chr3:11393739-11402151:-","gi|16758442|ref|NP_446086.1|",1695,0,"ficolin-2 precursor [Rattus norvegicus]","gi|298888542|emb|FQ220557.1|",1162,0,"Rattus norvegicus TL0ADA42YH06 mRNA sequence","P57756",657,0,"Ficolin-2",".",".",".",".","pfam00147","Fibrinogen_C","Fibrinogen beta and gamma chains, C-terminal globular domain.","GO:0001867|complement activation, lectin pathway;GO:0002752|cell surface pattern recognition receptor signaling pathway;GO:0007186|G protein-coupled receptor signaling pathway;GO:0032757|positive regulation of interleukin-8 production;GO:0034394|protein localization to cell surface;GO:0043654|recognition of apoptotic cell;GO:0046597|negative regulation of viral entry into host cell;","GO:0005581|collagen trimer;GO:0005615|extracellular space;GO:0031232|extrinsic component of external side of plasma membrane;GO:0062023|collagen-containing extracellular matrix;","GO:0001664|G protein-coupled receptor binding;GO:0003823|antigen binding;GO:0005102|signaling receptor binding;GO:0030246|carbohydrate binding;GO:0033691|sialic acid binding;GO:0038187|pattern recognition receptor activity;GO:0046872|metal ion binding;GO:0097367|carbohydrate derivative binding;","K10104","FCN; ficolin"]
["ENSRNOG00000009286",4,0.257321753,111,7.166366422,0.035906865,-4.799596486,{"v":3.50048e-27,"d":"3.50E-27"},{"v":7.07944e-27,"d":"7.08E-27"},"down","yes","Noxa1","protein_coding","chr3:7895488-7905967:-","gi|154090999|ref|NP_001093641.1|",2239,0,"NADPH oxidase activator 1 [Rattus norvegicus]","gi|672044662|ref|XM_006233600.2|",1581,0,"PREDICTED: Rattus norvegicus NADPH oxidase activator 1 (Noxa1), transcript variant X1, mRNA","A7E3N7",867,0,"NADPH oxidase activator 1",".",".",".",".","pfam00018","SH3_1","SH3 domain. SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta barrel.","GO:0006801|superoxide metabolic process;GO:0010310|regulation of hydrogen peroxide metabolic process;GO:0042554|superoxide anion generation;GO:0050790|regulation of catalytic activity;GO:0060263|regulation of respiratory burst;","GO:0005829|cytosol;GO:0043020|NADPH oxidase complex;","GO:0016176|superoxide-generating NADPH oxidase activator activity;GO:0017124|SH3 domain binding;GO:0019899|enzyme binding;GO:0031267|small GTPase binding;GO:0042802|identical protein binding;","K21432","NOXA1; NADPH oxidase activator 1"]
["ENSRNOG00000004048",241,15.5036356,537,34.66971863,0.447180889,-1.161069561,{"v":3.68485e-27,"d":"3.68E-27"},{"v":7.44704e-27,"d":"7.45E-27"},"down","yes","Lrrk2","protein_coding","chr7:122826696-122987703:+","gi|564361454|ref|XP_006242252.1|",13051,0,"PREDICTED: leucine-rich repeat serine/threonine-protein kinase 2 isoform X1 [Rattus norvegicus]","gi|672059902|ref|XM_006242190.2|",8081,0,"PREDICTED: Rattus norvegicus leucine-rich repeat kinase 2 (Lrrk2), transcript variant X1, mRNA","Q5S006",4773,0,"Leucine-rich repeat serine/threonine-protein kinase 2","alr0124_2",110,{"v":3E-23,"d":"3.00E-23"},"COG1100","pfam00069","Pkinase","Protein kinase domain.","GO:0000165|MAPK cascade;GO:0001933|negative regulation of protein phosphorylation;GO:0001934|positive regulation of protein phosphorylation;GO:0006468|protein phosphorylation;GO:0006470|protein dephosphorylation;GO:0006606|protein import into nucleus;GO:0006897|endocytosis;GO:0006979|response to oxidative stress;GO:0007005|mitochondrion organization;GO:0007029|endoplasmic reticulum organization;GO:0007030|Golgi organization;GO:0007040|lysosome organization;GO:0007165|signal transduction;GO:0007254|JNK cascade;GO:0007283|spermatogenesis;GO:0007528|neuromuscular junction development;GO:0008340|determination of adult lifespan;GO:0009267|cellular response to starvation;GO:0010468|regulation of gene expression;GO:0010506|regulation of autophagy;GO:0010508|positive regulation of autophagy;GO:0010738|regulation of protein kinase A signaling;GO:0010955|negative regulation of protein processing;GO:0010977|negative regulation of neuron projection development;GO:0014041|regulation of neuron maturation;GO:0016242|negative regulation of macroautophagy;GO:0016310|phosphorylation;GO:0018105|peptidyl-serine phosphorylation;GO:0018107|peptidyl-threonine phosphorylation;GO:0019722|calcium-mediated signaling;GO:0021756|striatum development;GO:0021772|olfactory bulb development;GO:0022028|tangential migration from the subventricular zone to the olfactory bulb;GO:0031398|positive regulation of protein ubiquitination;GO:0031647|regulation of protein stability;GO:0032091|negative regulation of protein binding;GO:0032092|positive regulation of protein binding;GO:0032436|positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032760|positive regulation of tumor necrosis factor production;GO:0034260|negative regulation of GTPase activity;GO:0034599|cellular response to oxidative stress;GO:0034613|cellular protein localization;GO:0035556|intracellular signal transduction;GO:0035564|regulation of kidney size;GO:0035640|exploration behavior;GO:0035641|locomotory exploration behavior;GO:0035751|regulation of lysosomal lumen pH;GO:0040012|regulation of locomotion;GO:0042391|regulation of membrane potential;GO:0043068|positive regulation of programmed cell death;GO:0043406|positive regulation of MAP kinase activity;GO:0045860|positive regulation of protein kinase activity;GO:0046039|GTP metabolic process;GO:0046777|protein autophosphorylation;GO:0048312|intracellular distribution of mitochondria;GO:0048812|neuron projection morphogenesis;GO:0051646|mitochondrion localization;GO:0051770|positive regulation of nitric-oxide synthase biosynthetic process;GO:0051900|regulation of mitochondrial depolarization;GO:0051966|regulation of synaptic transmission, glutamatergic;GO:0060079|excitatory postsynaptic potential;GO:0060159|regulation of dopamine receptor signaling pathway;GO:0060161|positive regulation of dopamine receptor signaling pathway;GO:0060628|regulation of ER to Golgi vesicle-mediated transport;GO:0060828|regulation of canonical Wnt signaling pathway;GO:0061001|regulation of dendritic spine morphogenesis;GO:0070973|protein localization to endoplasmic reticulum exit site;GO:0070997|neuron death;GO:0071287|cellular response to manganese ion;GO:0071407|cellular response to organic cyclic compound;GO:0072593|reactive oxygen species metabolic process;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:0090394|negative regulation of excitatory postsynaptic potential;GO:0140058|neuron projection arborization;GO:1900242|regulation of synaptic vesicle endocytosis;GO:1900244|positive regulation of synaptic vesicle endocytosis;GO:1901214|regulation of neuron death;GO:1901215|negative regulation of neuron death;GO:1901727|positive regulation of histone deacetylase activity;GO:1902236|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:1902499|positive regulation of protein autoubiquitination;GO:1902692|regulation of neuroblast proliferation;GO:1902803|regulation of synaptic vesicle transport;GO:1902902|negative regulation of autophagosome assembly;GO:1903125|negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation;GO:1903206|negative regulation of hydrogen peroxide-induced cell death;GO:1903215|negative regulation of protein targeting to mitochondrion;GO:1903351|cellular response to dopamine;GO:1903980|positive regulation of microglial cell activation;GO:1904887|Wnt signalosome assembly;GO:1905279|regulation of retrograde transport, endosome to Golgi;GO:1905289|regulation of CAMKK-AMPK signaling cascade;GO:2000172|regulation of branching morphogenesis of a nerve;GO:2000300|regulation of synaptic vesicle exocytosis;GO:2000469|negative regulation of peroxidase activity;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0005743|mitochondrial inner membrane;GO:0005759|mitochondrial matrix;GO:0005764|lysosome;GO:0005768|endosome;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005798|Golgi-associated vesicle;GO:0005802|trans-Golgi network;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005902|microvillus;GO:0008021|synaptic vesicle;GO:0016020|membrane;GO:0016234|inclusion body;GO:0030424|axon;GO:0030425|dendrite;GO:0030426|growth cone;GO:0031410|cytoplasmic vesicle;GO:0031966|mitochondrial membrane;GO:0032473|cytoplasmic side of mitochondrial outer membrane;GO:0032839|dendrite cytoplasm;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0043231|intracellular membrane-bounded organelle;GO:0044753|amphisome;GO:0044754|autolysosome;GO:0045121|membrane raft;GO:0045202|synapse;GO:0070971|endoplasmic reticulum exit site;GO:0097487|multivesicular body, internal vesicle;GO:0098794|postsynapse;GO:0098978|glutamatergic synapse;GO:0099400|caveola neck;GO:0099523|presynaptic cytosol;GO:1990904|ribonucleoprotein complex;GO:1990909|Wnt signalosome;","GO:0000149|SNARE binding;GO:0000287|magnesium ion binding;GO:0003674|molecular_function;GO:0003779|actin binding;GO:0003924|GTPase activity;GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0004709|MAP kinase kinase kinase activity;GO:0004722|protein serine/threonine phosphatase activity;GO:0005096|GTPase activator activity;GO:0005524|ATP binding;GO:0005525|GTP binding;GO:0015631|tubulin binding;GO:0016301|kinase activity;GO:0017075|syntaxin-1 binding;GO:0030276|clathrin binding;GO:0031267|small GTPase binding;GO:0034211|GTP-dependent protein kinase activity;GO:0036479|peroxidase inhibitor activity;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0044325|ion channel binding;GO:0051018|protein kinase A binding;GO:1904713|beta-catenin destruction complex binding;","K08844","LRRK2; leucine-rich repeat kinase 2 [EC:2.7.11.1]"]
["ENSRNOG00000013280",12,0.771965258,133,8.586727334,0.089902151,-3.475500554,{"v":4.93828e-27,"d":"4.94E-27"},{"v":9.9415e-27,"d":"9.94E-27"},"down","yes","Olfm4","protein_coding","chr15:55407148-55429681:+","gi|157823295|ref|NP_001099522.1|",2334,0,"olfactomedin-4 precursor [Rattus norvegicus]","gi|157823294|ref|NM_001106052.1|",2731,0,"Rattus norvegicus olfactomedin 4 (Olfm4), mRNA","Q3UZZ4",825,0,"Olfactomedin-4",".",".",".",".","pfam02191","OLF","Olfactomedin-like domain.","GO:0043124|negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0050777|negative regulation of immune response;GO:1900026|positive regulation of substrate adhesion-dependent cell spreading;","GO:0005615|extracellular space;GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0032991|protein-containing complex;GO:0042581|specific granule;GO:0045171|intercellular bridge;GO:0048471|perinuclear region of cytoplasm;","GO:0005198|structural molecule activity;GO:0045296|cadherin binding;","K25447","OLFM4; olfactomedin-4"]
["ENSRNOG00000012115",0,0.032165219,119,7.682861299,0.00418662,-7.899998383,{"v":5.67899E-27,"d":"5.68E-27"},{"v":1.14125e-26,"d":"1.14E-26"},"down","yes","ENSRNOG00000012115","protein_coding","chr9:106543723-106580907:-","gi|392342498|ref|XP_003754606.1|",2862,0,"PREDICTED: protein THEMIS3 [Rattus norvegicus]","gi|672024393|ref|XM_003754558.3|",1846,0,"PREDICTED: Rattus norvegicus hypothetical protein LOC689599 (LOC689599), mRNA",".",".",".",".",".",".",".",".","pfam12736","CABIT","Cell-cycle sustaining, positive selection,. The 'CABIT' domain (for 'cysteine-containing, all- in Themis') is found in a newly identified gene family that has three mammalian homologues (Themis, Icb1 and 9130404H23Rik) that encode proteins with two CABIT domains and a highly conserved proline-rich region. In contrast, Fam59A, Fam59B and related proteins from mammals to cnidarians, including the insect Serrano proteins, have a single copy of the CABIT domain, a proline-rich region and often a C-terminal SAM (sterile-motif) domain. Multiple-sequence alignment has predicted that the CABIT domain adopts an all-strand structure with at least 12 strands, ie a dyad of six-stranded beta-barrel units. The CABIT domain contains a nearly absolutely conserved cysteine residue which is likely to be central to its function. CABIT domain proteins function downstream of tyrosine kinase signalling and interact with GRB2.","GO:0050852|T cell receptor signaling pathway;","GO:0005634|nucleus;GO:0005737|cytoplasm;",".",".","."]
["ENSRNOG00000008323",155,9.971217919,402,25.95386758,0.384190059,-1.380107905,{"v":1.16757E-26,"d":"1.17E-26"},{"v":2.32834E-26,"d":"2.33E-26"},"down","yes","Pitpnm3","protein_coding","chr10:56676261-56766584:-","gi|672025646|ref|XP_008773984.1|",4572,0,"PREDICTED: membrane-associated phosphatidylinositol transfer protein 3 isoform X1 [Rattus norvegicus]","gi|672068317|ref|XM_008767927.1|",4833,0,"PREDICTED: Rattus norvegicus PITPNM family member 3 (Pitpnm3), transcript variant X2, mRNA","Q3UHE1",1739,0,"Membrane-associated phosphatidylinositol transfer protein 3","CAC2938",114,{"v":6e-26,"d":"6.00E-26"},"COG5083","pfam08235","LNS2","LNS2 (Lipin/Ned1/Smp2). This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain (Pfam: PF04571) and phosphatidylinositol transfer proteins. SMP2 (also known as PAH1) is involved in plasmid maintenance and respiration, and has been identified as a Mg2+-dependent phosphatidate phosphatase (EC:3.1.3.4) that contains a haloacid dehalogenase (HAD)-like domain. Lipin proteins are involved in adipose tissue development and insulin resistance.","GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0030134|COPII-coated ER to Golgi transport vesicle;GO:0042995|cell projection;GO:0044297|cell body;","GO:0004620|phospholipase activity;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0030971|receptor tyrosine kinase binding;","K24069","PITPNM; membrane-associated phosphatidylinositol transfer protein"]
["ENSRNOG00000021510",31,1.994243584,178,11.49201102,0.173533038,-2.52671774,{"v":1.35171e-26,"d":"1.35E-26"},{"v":2.6946e-26,"d":"2.69E-26"},"down","yes","Tbc1d10c","protein_coding","chr1:201477157-201564920:-","gi|126517485|ref|NP_001075449.1|",2069,0,"carabin [Rattus norvegicus]","gi|126517484|ref|NM_001081980.1|",1707,0,"Rattus norvegicus TBC1 domain family, member 10C (Tbc1d10c), mRNA","Q8C9V1",743,0,"Carabin","YGR100w",125,{"v":3e-29,"d":"3.00E-29"},"COG5210","pfam00566","RabGAP-TBC","Rab-GTPase-TBC domain. Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.","GO:0006886|intracellular protein transport;GO:0042147|retrograde transport, endosome to Golgi;GO:0050869|negative regulation of B cell activation;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0070885|negative regulation of calcineurin-NFAT signaling cascade;GO:0090630|activation of GTPase activity;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0031527|filopodium membrane;","GO:0005096|GTPase activator activity;","K19944","TBC1D10; TBC1 domain family member 10"]
["ENSRNOG00000013282",6,0.385982629,114,7.360052001,0.052442921,-4.253108133,{"v":1.55591e-26,"d":"1.56E-26"},{"v":3.09519E-26,"d":"3.10E-26"},"down","yes","Mctp1","protein_coding","chr2:6065808-6761833:+","gi|859882474|ref|XP_012899943.1|",3723,0,"PREDICTED: multiple C2 and transmembrane domain-containing protein 1 isoform X5 [Mustela putorius furo]","gi|34368616|gb|AC125565.5|",6627,0,"Rattus norvegicus 2 BAC CH230-9H16 (Children's Hospital Oakland Research Institute) complete sequence","D4ABL6",1559,0,"Multiple C2 and transmembrane domain-containing protein 1","SPAPYUK71.03c",68.9,{"v":3E-10,"d":"3.00E-10"},"COG5038","pfam00168","C2","C2 domain.","GO:0030336|negative regulation of cell migration;GO:0045806|negative regulation of endocytosis;GO:0046928|regulation of neurotransmitter secretion;GO:0048168|regulation of neuronal synaptic plasticity;GO:1902883|negative regulation of response to oxidative stress;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0030672|synaptic vesicle membrane;GO:0055037|recycling endosome;","GO:0005509|calcium ion binding;",".","."]
["ENSRNOG00000054495",9,0.578973944,122,7.876546878,0.073506062,-3.765992955,{"v":2.2727e-26,"d":"2.27E-26"},{"v":4.50542E-26,"d":"4.51E-26"},"down","yes","ENSRNOG00000054495","protein_coding","chrX:103459780-103474838:+","gi|157820641|ref|NP_001100316.1|",1018,{"v":1e-123,"d":"1.00E-123"},"claudin-2 [Rattus norvegicus]","gi|672088160|ref|XM_006234262.2|",3139,0,"PREDICTED: Rattus norvegicus claudin 2 (Cldn2), transcript variant X1, mRNA","O88552",394,{"v":2e-124,"d":"2.00E-124"},"Claudin-2",".",".",".",".","pfam00822","PMP22_Claudin","PMP-22/EMP/MP20/Claudin family.","GO:0007155|cell adhesion;GO:0016338|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;GO:0070830|bicellular tight junction assembly;","GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0005923|bicellular tight junction;GO:0016021|integral component of membrane;","GO:0005198|structural molecule activity;GO:0042802|identical protein binding;","K06087","CLDN; claudin"]
["ENSRNOG00000015588",170,10.93617449,423,27.30966663,0.400450677,-1.320303536,{"v":3.07473e-26,"d":"3.07E-26"},{"v":6.0681e-26,"d":"6.07E-26"},"down","yes","Nol3","protein_coding","chr19:33154062-33158250:+","gi|564395619|ref|XP_006255601.1|",664,{"v":1E-79,"d":"1.00E-79"},"PREDICTED: nucleolar protein 3 isoform X1 [Rattus norvegicus]","gi|672084962|ref|XM_008772540.1|",1522,0,"PREDICTED: Rattus norvegicus nucleolar protein 3 (apoptosis repressor with CARD domain) (Nol3), transcript variant X2, mRNA","Q62881",260,{"v":4e-81,"d":"4.00E-81"},"Nucleolar protein 3",".",".",".",".","pfam00619","CARD","Caspase recruitment domain. Motif contained in proteins involved in apoptotic signaling. Predicted to possess a DEATH (pfam00531) domain-like fold.","GO:0001666|response to hypoxia;GO:0001974|blood vessel remodeling;GO:0002931|response to ischemia;GO:0006376|mRNA splice site selection;GO:0010468|regulation of gene expression;GO:0010659|cardiac muscle cell apoptotic process;GO:0010664|negative regulation of striated muscle cell apoptotic process;GO:0010667|negative regulation of cardiac muscle cell apoptotic process;GO:0010804|negative regulation of tumor necrosis factor-mediated signaling pathway;GO:0010880|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0014736|negative regulation of muscle atrophy;GO:0014808|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0014876|response to injury involved in regulation of muscle adaptation;GO:0042981|regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045445|myoblast differentiation;GO:0048659|smooth muscle cell proliferation;GO:0051259|protein complex oligomerization;GO:0051481|negative regulation of cytosolic calcium ion concentration;GO:0051562|negative regulation of mitochondrial calcium ion concentration;GO:0060547|negative regulation of necrotic cell death;GO:0071456|cellular response to hypoxia;GO:0090201|negative regulation of release of cytochrome c from mitochondria;GO:0097193|intrinsic apoptotic signaling pathway;GO:0097340|inhibition of cysteine-type endopeptidase activity;GO:1901222|regulation of NIK/NF-kappaB signaling;GO:1902042|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1902109|negative regulation of mitochondrial membrane permeability involved in apoptotic process;GO:1902176|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;GO:1903073|negative regulation of death-inducing signaling complex assembly;GO:1903206|negative regulation of hydrogen peroxide-induced cell death;GO:1903215|negative regulation of protein targeting to mitochondrion;GO:1903298|negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway;GO:1990001|inhibition of cysteine-type endopeptidase activity involved in apoptotic process;GO:2001237|negative regulation of extrinsic apoptotic signaling pathway;GO:2001243|negative regulation of intrinsic apoptotic signaling pathway;","GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0016020|membrane;GO:0016528|sarcoplasm;GO:0016529|sarcoplasmic reticulum;","GO:0005102|signaling receptor binding;GO:0005123|death receptor binding;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0019900|kinase binding;GO:0019902|phosphatase binding;GO:0035877|death effector domain binding;GO:0042802|identical protein binding;GO:0043027|cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0089720|caspase binding;",".","."]
["ENSRNOG00000000441",80,5.146435055,273,17.62538769,0.291989892,-1.776009665,{"v":3.60827e-26,"d":"3.61E-26"},{"v":7.10863e-26,"d":"7.11E-26"},"down","yes","Gpsm3","protein_coding","chr20:4157123-4159035:-","gi|51571901|ref|NP_001003974.1|",339,{"v":3E-34,"d":"3.00E-34"},"G-protein-signaling modulator 3 [Rattus norvegicus]","gi|56961638|ref|NM_001003974.2|",781,0,"Rattus norvegicus G-protein signaling modulator 3 (Gpsm3), mRNA","Q6MG88",135,{"v":9e-36,"d":"9.00E-36"},"G-protein-signaling modulator 3",".",".",".",".","pfam02188","GoLoco","GoLoco motif.","GO:0002690|positive regulation of leukocyte chemotaxis;GO:0006955|immune response;GO:0050729|positive regulation of inflammatory response;GO:0050790|regulation of catalytic activity;GO:1900017|positive regulation of cytokine production involved in inflammatory response;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;","GO:0030695|GTPase regulator activity;","K15838","GPSM3, AGS4; G-protein signaling modulator 3"]
["ENSRNOG00000020714",289,18.59149664,599,38.67255393,0.480741372,-1.05666713,{"v":4.36746e-26,"d":"4.37E-26"},{"v":8.57178e-26,"d":"8.57E-26"},"down","yes","Trpm4","protein_coding","chr1:95782000-95812532:-","gi|209977101|ref|NP_001129701.1|",5622,0,"transient receptor potential cation channel subfamily M member 4 [Rattus norvegicus]","gi|209977100|ref|NM_001136229.1|",4203,0,"Rattus norvegicus transient receptor potential cation channel, subfamily M, member 4 (Trpm4), mRNA","Q9ESQ5",2170,0,"Transient receptor potential cation channel subfamily M member 4",".",".",".",".","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0002250|adaptive immune response;GO:0002407|dendritic cell chemotaxis;GO:0002724|regulation of T cell cytokine production;GO:0006816|calcium ion transport;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0008284|positive regulation of cell proliferation;GO:0010460|positive regulation of heart rate;GO:0016925|protein sumoylation;GO:0019722|calcium-mediated signaling;GO:0030502|negative regulation of bone mineralization;GO:0035774|positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0042310|vasoconstriction;GO:0045600|positive regulation of fat cell differentiation;GO:0045668|negative regulation of osteoblast differentiation;GO:0045907|positive regulation of vasoconstriction;GO:0051289|protein homotetramerization;GO:0070588|calcium ion transmembrane transport;GO:0071318|cellular response to ATP;GO:0086045|membrane depolarization during AV node cell action potential;GO:0086047|membrane depolarization during Purkinje myocyte cell action potential;GO:0086048|membrane depolarization during bundle of His cell action potential;GO:0086091|regulation of heart rate by cardiac conduction;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:0098655|cation transmembrane transport;GO:0098662|inorganic cation transmembrane transport;GO:0098719|sodium ion import across plasma membrane;GO:0098911|regulation of ventricular cardiac muscle cell action potential;GO:1903949|positive regulation of atrial cardiac muscle cell action potential;GO:1904179|positive regulation of adipose tissue development;GO:1904199|positive regulation of regulation of vascular smooth muscle cell membrane depolarization;","GO:0005654|nucleoplasm;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0034706|sodium channel complex;GO:0043025|neuronal cell body;GO:0044214|spanning component of plasma membrane;GO:0089717|spanning component of membrane;","GO:0005227|calcium activated cation channel activity;GO:0005261|cation channel activity;GO:0005262|calcium channel activity;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0005516|calmodulin binding;GO:0005524|ATP binding;GO:0042802|identical protein binding;GO:0099604|ligand-gated calcium channel activity;","K04979","TRPM4; transient receptor potential cation channel subfamily M member 4"]
["ENSRNOG00000046663",130,8.362956964,358,23.11314576,0.36182686,-1.466628584,{"v":4.65419e-26,"d":"4.65E-26"},{"v":9.13141e-26,"d":"9.13E-26"},"down","yes","Fcgr2a","protein_coding","chr13:83280790-83484920:-","gi|672074912|ref|XP_008767999.1|",1263,{"v":4e-164,"d":"4.00E-164"},"PREDICTED: low affinity immunoglobulin gamma Fc region receptor III-like isoform X2 [Rattus norvegicus]","gi|298894770|emb|FQ230932.1|",1294,0,"Rattus norvegicus TL0AEA7YO18 mRNA sequence","P27645",482,{"v":3E-162,"d":"3.00E-162"},"Low affinity immunoglobulin gamma Fc region receptor III",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0001788|antibody-dependent cellular cytotoxicity;GO:0001798|positive regulation of type IIa hypersensitivity;GO:0001805|positive regulation of type III hypersensitivity;GO:0001812|positive regulation of type I hypersensitivity;GO:0001813|regulation of antibody-dependent cellular cytotoxicity;GO:0001820|serotonin secretion;GO:0006910|phagocytosis, recognition;GO:0006911|phagocytosis, engulfment;GO:0007166|cell surface receptor signaling pathway;GO:0021675|nerve development;GO:0030593|neutrophil chemotaxis;GO:0032680|regulation of tumor necrosis factor production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0038094|Fc-gamma receptor signaling pathway;GO:0042590|antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:0045576|mast cell activation;GO:0050766|positive regulation of phagocytosis;GO:0050776|regulation of immune response;GO:1905449|regulation of Fc-gamma receptor signaling pathway involved in phagocytosis;","GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0004888|transmembrane signaling receptor activity;GO:0019770|IgG receptor activity;GO:0019864|IgG binding;GO:0034987|immunoglobulin receptor binding;","K06463","FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor IIIK06463; K06472"]
["ENSRNOG00000049422",83,5.339426369,277,17.88363512,0.298564936,-1.743883354,{"v":6.63002e-26,"d":"6.63E-26"},{"v":1.2959E-25,"d":"1.30E-25"},"down","yes","Fcgr2a","protein_coding","chr13:83280784-83295967:-","gi|31542804|ref|NP_446295.2|",1383,0,"low affinity immunoglobulin gamma Fc region receptor III [Rattus norvegicus]","gi|672074740|ref|XM_006250303.2|",1593,0,"PREDICTED: Rattus norvegicus Fc fragment of IgG, low affinity IIa, receptor (Fcgr2a), transcript variant X1, mRNA","P27645",473,{"v":7e-164,"d":"7.00E-164"},"Low affinity immunoglobulin gamma Fc region receptor III",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0001788|antibody-dependent cellular cytotoxicity;GO:0001798|positive regulation of type IIa hypersensitivity;GO:0001805|positive regulation of type III hypersensitivity;GO:0001812|positive regulation of type I hypersensitivity;GO:0001813|regulation of antibody-dependent cellular cytotoxicity;GO:0001820|serotonin secretion;GO:0006910|phagocytosis, recognition;GO:0006911|phagocytosis, engulfment;GO:0007166|cell surface receptor signaling pathway;GO:0021675|nerve development;GO:0030593|neutrophil chemotaxis;GO:0032680|regulation of tumor necrosis factor production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0038094|Fc-gamma receptor signaling pathway;GO:0042590|antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:0045576|mast cell activation;GO:0050766|positive regulation of phagocytosis;GO:0050776|regulation of immune response;GO:1905449|regulation of Fc-gamma receptor signaling pathway involved in phagocytosis;","GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0004888|transmembrane signaling receptor activity;GO:0019770|IgG receptor activity;GO:0019864|IgG binding;GO:0034987|immunoglobulin receptor binding;","K06463","FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III"]
["ENSRNOG00000018551",22,1.41526964,154,9.942526387,0.142345073,-2.812535541,{"v":7.20667e-26,"d":"7.21E-26"},{"v":1.40572e-25,"d":"1.41E-25"},"down","yes","Olr63","protein_coding","chr1:157142352-157149671:+","gi|47577687|ref|NP_001000542.1|",1580,0,"olfactory receptor Olr63 [Rattus norvegicus]","gi|672038011|ref|XM_006229890.2|",1491,0,"PREDICTED: Rattus norvegicus olfactory receptor 63 (Olr63), transcript variant X1, mRNA","Q8TCB6",568,0,"Olfactory receptor 51E1",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0050911|detection of chemical stimulus involved in sensory perception of smell;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004984|olfactory receptor activity;","K04257","OLFR; olfactory receptor"]
["ENSRNOG00000007437",142,9.134922222,376,24.27525923,0.376305857,-1.410022352,{"v":8.16495e-26,"d":"8.16E-26"},{"v":1.58993e-25,"d":"1.59E-25"},"down","yes","Irf5","protein_coding","chr4:58127640-58139267:+","gi|564346042|ref|XP_006236242.1|",2637,0,"PREDICTED: interferon regulatory factor 5 isoform X1 [Rattus norvegicus]","gi|672049100|ref|XM_006236180.2|",2942,0,"PREDICTED: Rattus norvegicus interferon regulatory factor 5 (Irf5), transcript variant X1, mRNA","P56477",904,0,"Interferon regulatory factor 5",".",".",".",".","pfam10401","IRF-3","Interferon-regulatory factor 3. This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1).  Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.","GO:0002376|immune system process;GO:0006357|regulation of transcription by RNA polymerase II;GO:0019221|cytokine-mediated signaling pathway;GO:0032481|positive regulation of type I interferon production;GO:0032494|response to peptidoglycan;GO:0032495|response to muramyl dipeptide;GO:0043065|positive regulation of apoptotic process;GO:0045087|innate immune response;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051607|defense response to virus;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0019901|protein kinase binding;GO:0042802|identical protein binding;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09446","IRF5; interferon regulatory factor 5"]
["ENSRNOG00000017093",239,15.37497473,524,33.83041446,0.454471959,-1.137736813,{"v":9.56759e-26,"d":"9.57E-26"},{"v":1.85989e-25,"d":"1.86E-25"},"down","yes","Pxdc1","protein_coding","chr17:30276377-30304973:+","gi|149045220|gb|EDL98306.1|",1183,{"v":6e-156,"d":"6.00E-156"},"similar to 1300014I06Rik protein, isoform CRA_a [Rattus norvegicus]","gi|22477998|gb|BC037079.1|",1234,0,"Mus musculus RIKEN cDNA 1300014I06 gene, mRNA (cDNA clone MGC:46991 IMAGE:5051974), complete cds","Q4KLK8",323,{"v":6e-104,"d":"6.00E-104"},"PX domain-containing protein 1",".",".",".",".","pfam09559","Cas6","Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defence against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.",".",".","GO:0035091|phosphatidylinositol binding;",".","."]
["ENSRNOG00000039759",8,0.514643505,116,7.48917572,0.068718311,-3.863161614,{"v":1.45605e-25,"d":"1.46E-25"},{"v":2.81802e-25,"d":"2.82E-25"},"down","yes","ENSRNOG00000039759","protein_coding","chrX:9104565-9148601:-","gi|67972437|ref|NP_001020096.1|",1970,0,"probable G-protein coupled receptor 34 [Rattus norvegicus]","gi|672086955|ref|XM_006256676.2|",1977,0,"PREDICTED: Rattus norvegicus G protein-coupled receptor 34 (Gpr34), transcript variant X2, mRNA","Q9R1K6",728,0,"Probable G-protein coupled receptor 34",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0035589|G protein-coupled purinergic nucleotide receptor signaling pathway;","GO:0016021|integral component of membrane;","GO:0045028|G protein-coupled purinergic nucleotide receptor activity;","K08383","GPR34; G protein-coupled receptor 34"]
["ENSRNOG00000032626",7,0.450313067,113,7.295490141,0.061724854,-4.01800466,{"v":1.56135E-25,"d":"1.56E-25"},{"v":3.01977E-25,"d":"3.02E-25"},"down","yes","Mmp3","protein_coding","chr8:4640416-4653961:+","gi|293597556|ref|NP_598207.2|",2549,0,"stromelysin-1 preproprotein [Rattus norvegicus]","gi|695917201|ref|NM_133523.3|",1827,0,"Rattus norvegicus matrix metallopeptidase 3 (Mmp3), mRNA","P03957",981,0,"Stromelysin-1",".",".",".",".","pfam00413","Peptidase_M10","Matrixin. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.","GO:0001666|response to hypoxia;GO:0006508|proteolysis;GO:0007565|female pregnancy;GO:0009612|response to mechanical stimulus;GO:0010727|negative regulation of hydrogen peroxide metabolic process;GO:0030163|protein catabolic process;GO:0030198|extracellular matrix organization;GO:0030334|regulation of cell migration;GO:0030335|positive regulation of cell migration;GO:0030574|collagen catabolic process;GO:0031334|positive regulation of protein complex assembly;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0034097|response to cytokine;GO:0034612|response to tumor necrosis factor;GO:0042060|wound healing;GO:0043200|response to amino acid;GO:0051898|negative regulation of protein kinase B signaling;GO:0070555|response to interleukin-1;GO:0071230|cellular response to amino acid stimulus;GO:0071347|cellular response to interleukin-1;GO:0071460|cellular response to cell-matrix adhesion;GO:0071492|cellular response to UV-A;GO:1903209|positive regulation of oxidative stress-induced cell death;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005739|mitochondrion;GO:0005829|cytosol;GO:0030425|dendrite;GO:0031012|extracellular matrix;GO:0032991|protein-containing complex;GO:0044297|cell body;","GO:0004175|endopeptidase activity;GO:0004222|metalloendopeptidase activity;GO:0008233|peptidase activity;GO:0008237|metallopeptidase activity;GO:0008270|zinc ion binding;GO:0044877|protein-containing complex binding;","K01394","MMP3; matrix metalloproteinase-3 (stromelysin 1, progelatinase) [EC:3.4.24.17]"]
["ENSRNOG00000026136",232,14.92466166,511,32.99111028,0.45238434,-1.144379105,{"v":2.28219E-25,"d":"2.28E-25"},{"v":4.39458e-25,"d":"4.39E-25"},"down","yes","Tnfaip8","protein_coding","chr18:43183916-43299517:+","gi|564393409|ref|XP_006254770.1|",1011,{"v":5e-126,"d":"5.00E-126"},"PREDICTED: tumor necrosis factor alpha-induced protein 8 isoform X2 [Rattus norvegicus]","gi|672083481|ref|XM_006254708.2|",3326,0,"PREDICTED: Rattus norvegicus tumor necrosis factor, alpha-induced protein 8 (Tnfaip8), transcript variant X2, mRNA","Q921Z5",384,{"v":7e-124,"d":"7.00E-124"},"Tumor necrosis factor alpha-induced protein 8",".",".",".",".","pfam05527","DUF758","Domain of unknown function (DUF758). Family of eukaryotic proteins with unknown function, which are induced by tumor necrosis factor.","GO:0006915|apoptotic process;GO:0043065|positive regulation of apoptotic process;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0050830|defense response to Gram-positive bacterium;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;","GO:0043027|cysteine-type endopeptidase inhibitor activity involved in apoptotic process;",".","."]
["ENSRNOG00000007610",99,6.36871338,302,19.49768162,0.326639521,-1.614228739,{"v":2.38428E-25,"d":"2.38E-25"},{"v":4.58805e-25,"d":"4.59E-25"},"down","yes","Gdf11","protein_coding","chr7:1311732-1320725:-","gi|291389390|ref|XP_002711212.1|",1799,0,"PREDICTED: growth/differentiation factor 11 [Oryctolagus cuniculus]","gi|402767037|ref|NM_017203.1|",4013,0,"Rattus norvegicus growth differentiation factor 11 (Gdf11), mRNA","O95390",691,0,"Growth/differentiation factor 11",".",".",".",".","pfam00688","TGFb_propeptide","TGF-beta propeptide. This propeptide is known as latency associated peptide (LAP) in TGF-beta. LAP is a homodimer which is disulfide linked to TGF-beta binding protein.","GO:0001501|skeletal system development;GO:0001656|metanephros development;GO:0001657|ureteric bud development;GO:0008285|negative regulation of cell proliferation;GO:0009887|animal organ morphogenesis;GO:0009952|anterior/posterior pattern specification;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0021512|spinal cord anterior/posterior patterning;GO:0031016|pancreas development;GO:0045596|negative regulation of cell differentiation;GO:0045665|negative regulation of neuron differentiation;GO:0048469|cell maturation;GO:0048593|camera-type eye morphogenesis;GO:0060021|roof of mouth development;GO:0060395|SMAD protein signal transduction;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005654|nucleoplasm;GO:0032991|protein-containing complex;GO:0043231|intracellular membrane-bounded organelle;","GO:0003674|molecular_function;GO:0005125|cytokine activity;GO:0008083|growth factor activity;","K22679","GDF11; growth differentiation factor 11"]
["ENSRNOG00000018978",3,0.192991315,101,6.520747825,0.0295965,-5.078429601,{"v":2.90559e-25,"d":"2.91E-25"},{"v":5.57243e-25,"d":"5.57E-25"},"down","yes","Scart1","protein_coding","chr1:195020750-195031807:+","gi|149061488|gb|EDM11911.1|",5011,0,"rCG47791, isoform CRA_b [Rattus norvegicus]","gi|157821230|ref|NM_001106312.1|",3228,0,"Rattus norvegicus CD163 molecule-like 1 (Cd163l1), mRNA","Q4G0T1",1067,0,"Scavenger receptor cysteine-rich domain-containing protein SCART1",".",".",".",".","pfam00530","SRCR","Scavenger receptor cysteine-rich domain. These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.","GO:0006897|endocytosis;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005903|brush border;GO:0009897|external side of plasma membrane;","GO:0005044|scavenger receptor activity;",".","."]
["ENSRNOG00000024657",36,2.315895775,183,11.81482032,0.196016166,-2.350955456,{"v":3.02168e-25,"d":"3.02E-25"},{"v":5.79314e-25,"d":"5.79E-25"},"down","yes","Mfsd4a","protein_coding","chr13:43469488-43510467:-","gi|564380547|ref|XP_006249853.1|",2589,0,"PREDICTED: major facilitator superfamily domain-containing protein 4 isoform X1 [Rattus norvegicus]","gi|672073824|ref|XM_006249791.2|",3742,0,"PREDICTED: Rattus norvegicus major facilitator superfamily domain containing 4 (Mfsd4), transcript variant X1, mRNA","Q6PDC8",961,0,"Major facilitator superfamily domain-containing protein 4A",".",".",".",".","pfam07690","MFS_1","Major Facilitator Superfamily.","GO:1904659|glucose transmembrane transport;","GO:0016021|integral component of membrane;","GO:0005355|glucose transmembrane transporter activity;",".","."]
["ENSRNOG00000020136",43,2.766208842,197,12.71868635,0.21749171,-2.200967684,{"v":4.21718e-25,"d":"4.22E-25"},{"v":8.03926E-25,"d":"8.04E-25"},"down","yes","Tgm1","protein_coding","chr15:29191041-29204523:-","gi|13928912|ref|NP_113847.1|",3950,0,"protein-glutamine gamma-glutamyltransferase K [Rattus norvegicus]","gi|672078098|ref|XM_006252014.2|",2644,0,"PREDICTED: Rattus norvegicus transglutaminase 1 (Tgm1), transcript variant X1, mRNA","P23606",1516,0,"Protein-glutamine gamma-glutamyltransferase K",".",".",".",".","pfam00868","Transglut_N","Transglutaminase family.","GO:0009887|animal organ morphogenesis;GO:0010838|positive regulation of keratinocyte proliferation;GO:0018149|peptide cross-linking;GO:0030216|keratinocyte differentiation;GO:0031424|keratinization;GO:0045787|positive regulation of cell cycle;","GO:0005575|cellular_component;GO:0005912|adherens junction;GO:0016020|membrane;GO:0031224|intrinsic component of membrane;","GO:0003810|protein-glutamine gamma-glutamyltransferase activity;GO:0042802|identical protein binding;GO:0046872|metal ion binding;","K05619","TGM1; transglutaminase 1 [EC:2.3.2.13]"]
["ENSRNOG00000030889",13,0.836295696,128,8.263918036,0.10119845,-3.304740901,{"v":4.40189e-25,"d":"4.40E-25"},{"v":8.38858e-25,"d":"8.39E-25"},"down","yes","Cldn22","protein_coding","chr16:44422345-44423354:-","gi|158636022|ref|NP_001103613.1|",720,{"v":6e-91,"d":"6.00E-91"},"claudin-22 [Rattus norvegicus]","gi|158636021|ref|NM_001110143.1|",1010,0,"Rattus norvegicus claudin 22 (Cldn22), mRNA","Q9D7U6",262,{"v":7e-85,"d":"7.00E-85"},"Claudin-22",".",".",".",".","pfam00822","PMP22_Claudin","PMP-22/EMP/MP20/Claudin family.","GO:0007155|cell adhesion;GO:0070830|bicellular tight junction assembly;","GO:0005886|plasma membrane;GO:0005923|bicellular tight junction;GO:0016021|integral component of membrane;","GO:0005198|structural molecule activity;","K06087","CLDN; claudin"]
["ENSRNOG00000064449",120,7.719652582,335,21.62822298,0.356924958,-1.486307309,{"v":6.01397e-25,"d":"6.01E-25"},{"v":1.14188e-24,"d":"1.14E-24"},"down","yes","ENSRNOG00000064449","lncRNA","chr4:120650221-120658316:-","gi|953875486|ref|XP_014586861.1|",181,{"v":1e-11,"d":"1.00E-11"},"PREDICTED: uncharacterized protein LOC102149826 isoform X1 [Equus caballus]","gi|78675476|dbj|AB218617.1|",1363,0,"Rattus norvegicus genomic DNA, chromosome 4, clone: CH230-65K18, complete sequence",".",".",".",".",".",".",".",".","pfam03154","Atrophin-1","Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.",".",".",".",".","."]
["ENSRNOG00000011431",111,7.140678639,320,20.65979509,0.345631629,-1.532692848,{"v":6.1522e-25,"d":"6.15E-25"},{"v":1.16735E-24,"d":"1.17E-24"},"down","yes","Mfhas1","protein_coding","chr16:56546207-56633743:-","gi|564389396|ref|XP_006253286.1|",5066,0,"PREDICTED: malignant fibrous histiocytoma-amplified sequence 1 isoform X2 [Rattus norvegicus]","gi|672080317|ref|XM_006253224.2|",5108,0,"PREDICTED: Rattus norvegicus malignant fibrous histiocytoma amplified sequence 1 (Mfhas1), transcript variant X1, mRNA","Q3V1N1",1946,0,"Malignant fibrous histiocytoma-amplified sequence 1 homolog","alr0124_1",135,{"v":6e-32,"d":"6.00E-32"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0006952|defense response;GO:0006954|inflammatory response;GO:0008150|biological_process;GO:0030218|erythrocyte differentiation;GO:0034121|regulation of toll-like receptor signaling pathway;GO:0034136|negative regulation of toll-like receptor 2 signaling pathway;GO:0034137|positive regulation of toll-like receptor 2 signaling pathway;GO:0034144|negative regulation of toll-like receptor 4 signaling pathway;GO:0035308|negative regulation of protein dephosphorylation;GO:0043030|regulation of macrophage activation;GO:0045087|innate immune response;GO:0046330|positive regulation of JNK cascade;GO:0050728|negative regulation of inflammatory response;GO:0051897|positive regulation of protein kinase B signaling;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:1900181|negative regulation of protein localization to nucleus;GO:1900745|positive regulation of p38MAPK cascade;","GO:0005575|cellular_component;GO:0005737|cytoplasm;","GO:0003674|molecular_function;GO:0005525|GTP binding;GO:0031625|ubiquitin protein ligase binding;GO:0051721|protein phosphatase 2A binding;",".","."]
["ENSRNOG00000027125",259,16.66158349,546,35.25077537,0.472658638,-1.081129473,{"v":9.05621e-25,"d":"9.06E-25"},{"v":1.71268E-24,"d":"1.71E-24"},"down","yes","Mboat1","protein_coding","chr17:34331422-34445088:-","gi|157819873|ref|NP_001102590.1|",2337,0,"lysophospholipid acyltransferase 1 [Rattus norvegicus]","gi|157819872|ref|NM_001109120.1|",2853,0,"Rattus norvegicus membrane bound O-acyltransferase domain containing 1 (Mboat1), mRNA","Q8BH98",874,0,"Lysophospholipid acyltransferase 1","YOR175c",160,{"v":3e-40,"d":"3.00E-40"},"COG5202","pfam03062","MBOAT","MBOAT, membrane-bound O-acyltransferase family. The MBOAT (membrane bound O-acyl transferase) family of membrane proteins contains a variety of acyltransferase enzymes. A conserved histidine has been suggested to be the active site residue.","GO:0008654|phospholipid biosynthetic process;GO:0010975|regulation of neuron projection development;GO:0030258|lipid modification;GO:0036150|phosphatidylserine acyl-chain remodeling;GO:0036152|phosphatidylethanolamine acyl-chain remodeling;","GO:0005789|endoplasmic reticulum membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0016746|transferase activity, transferring acyl groups;","K13517","MBOAT1_2; lysophospholipid acyltransferase 1/2 [EC:2.3.1.51 2.3.1.-]"]
["ENSRNOG00000058308",19,1.222278326,142,9.167784071,0.133323202,-2.907000225,{"v":9.74709e-25,"d":"9.75E-25"},{"v":1.84089e-24,"d":"1.84E-24"},"down","yes","Asic2","protein_coding","chr10:65870594-66940424:-","gi|77404415|ref|NP_001029186.1|",2566,0,"acid-sensing ion channel 2 isoform MDEG1 [Rattus norvegicus]","gi|77404414|ref|NM_001034014.1|",2389,0,"Rattus norvegicus acid sensing ion channel subunit 2 (Asic2), transcript variant MDEG1, mRNA","Q62962",993,0,"Acid-sensing ion channel 2",".",".",".",".","pfam00858","ASC","Amiloride-sensitive sodium channel.","GO:0003026|regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback;GO:0006812|cation transport;GO:0006814|sodium ion transport;GO:0007602|phototransduction;GO:0007605|sensory perception of sound;GO:0009612|response to mechanical stimulus;GO:0010447|response to acidic pH;GO:0019229|regulation of vasoconstriction;GO:0034220|ion transmembrane transport;GO:0034765|regulation of ion transmembrane transport;GO:0035418|protein localization to synapse;GO:0035725|sodium ion transmembrane transport;GO:0042391|regulation of membrane potential;GO:0043066|negative regulation of apoptotic process;GO:0050915|sensory perception of sour taste;GO:0050974|detection of mechanical stimulus involved in sensory perception;GO:0051965|positive regulation of synapse assembly;GO:0071466|cellular response to xenobiotic stimulus;GO:0071468|cellular response to acidic pH;GO:2001259|positive regulation of cation channel activity;","GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043197|dendritic spine;GO:0045202|synapse;","GO:0005216|ion channel activity;GO:0005248|voltage-gated sodium channel activity;GO:0005261|cation channel activity;GO:0005515|protein binding;GO:0015280|ligand-gated sodium channel activity;GO:0022839|ion gated channel activity;","K04828","ASIC2, ACCN1, BNAC1; acid-sensing ion channel 2"]
["ENSRNOG00000020518",307,19.74944452,613,39.57641997,0.499020491,-1.002829038,{"v":1.34685e-24,"d":"1.35E-24"},{"v":2.53619e-24,"d":"2.54E-24"},"down","yes","Fam189b","protein_coding","chr2:174589337-174595281:+","gi|672042996|ref|XP_008759391.1|",2642,0,"PREDICTED: protein FAM189B isoform X10 [Rattus norvegicus]","gi|672042995|ref|XM_008761169.1|",3131,0,"PREDICTED: Rattus norvegicus family with sequence similarity 189, member B (Fam189b), transcript variant X10, mRNA","Q5HZJ5",983,0,"Protein FAM189B",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.",".","GO:0016021|integral component of membrane;","GO:0050699|WW domain binding;",".","."]
["ENSRNOG00000020355",15,0.964956573,131,8.457603615,0.114093379,-3.131713025,{"v":1.62003E-24,"d":"1.62E-24"},{"v":3.04558E-24,"d":"3.05E-24"},"down","yes","Twist2","protein_coding","chr9:92374574-92419222:+","gi|6681177|ref|NP_031881.1|",842,{"v":1E-108,"d":"1.00E-108"},"twist-related protein 2 [Mus musculus]","gi|158186714|ref|NM_021691.2|",1183,0,"Rattus norvegicus twist family bHLH transcription factor 2 (Twist2), mRNA","P97831",328,{"v":5E-110,"d":"5.00E-110"},"Twist-related protein 2",".",".",".",".","pfam00010","HLH","Helix-loop-helix DNA-binding domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001649|osteoblast differentiation;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008285|negative regulation of cell proliferation;GO:0010838|positive regulation of keratinocyte proliferation;GO:0030335|positive regulation of cell migration;GO:0032502|developmental process;GO:0032720|negative regulation of tumor necrosis factor production;GO:0043066|negative regulation of apoptotic process;GO:0043392|negative regulation of DNA binding;GO:0044092|negative regulation of molecular function;GO:0045638|negative regulation of myeloid cell differentiation;GO:0045668|negative regulation of osteoblast differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0048701|embryonic cranial skeleton morphogenesis;GO:0060325|face morphogenesis;GO:0061303|cornea development in camera-type eye;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005730|nucleolus;GO:0005737|cytoplasm;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003682|chromatin binding;GO:0003700|DNA-binding transcription factor activity;GO:0019904|protein domain specific binding;GO:0046983|protein dimerization activity;","K09069","TWIST; twist"]
["ENSRNOG00000020904",125,8.041304773,340,21.95103228,0.366329231,-1.448787271,{"v":2.07321e-24,"d":"2.07E-24"},{"v":3.88476e-24,"d":"3.88E-24"},"down","yes","Cdc42ep2","protein_coding","chr1:203201873-203210897:-","gi|57527380|ref|NP_001009689.1|",964,{"v":1e-121,"d":"1.00E-121"},"cdc42 effector protein 2 [Rattus norvegicus]","gi|672039374|ref|XM_006230806.2|",1673,0,"PREDICTED: Rattus norvegicus CDC42 effector protein (Rho GTPase binding) 2 (Cdc42ep2), transcript variant X2, mRNA","Q5PQP4",375,{"v":4e-123,"d":"4.00E-123"},"Cdc42 effector protein 2",".",".",".",".","pfam14957","BORG_CEP","Cdc42 effector. The Cdc42 effector (CEP) or binder of Rho GTPases (BORG) proteins are involved in the organisation of the actin cytoskeleton. They may function as negative regulators of Rho GTPase signaling.","GO:0007266|Rho protein signal transduction;GO:0008360|regulation of cell shape;GO:0030036|actin cytoskeleton organization;GO:0030838|positive regulation of actin filament polymerization;GO:0031274|positive regulation of pseudopodium assembly;GO:0050790|regulation of catalytic activity;GO:0071346|cellular response to interferon-gamma;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0012505|endomembrane system;GO:0015630|microtubule cytoskeleton;GO:0016020|membrane;GO:0045335|phagocytic vesicle;","GO:0001515|opioid peptide activity;GO:0005096|GTPase activator activity;GO:0031267|small GTPase binding;",".","."]
["ENSRNOG00000052634",68,4.374469797,242,15.62397004,0.279984523,-1.836581015,{"v":2.07912e-24,"d":"2.08E-24"},{"v":3.89456e-24,"d":"3.89E-24"},"down","yes","Lsmem2","protein_coding","chr8:108266345-108279115:-","gi|121583784|ref|NP_001073411.1|",3783,0,"semaphorin-3B precursor [Rattus norvegicus]","gi|672063083|ref|XM_008766551.1|",2747,0,"PREDICTED: Rattus norvegicus sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B (Sema3b), transcript variant X3, mRNA","Q62177",1374,0,"Semaphorin-3B",".",".",".",".","pfam01403","Sema","Sema domain. The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and human plexin A-3.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000015578",39,2.508887089,185,11.94394404,0.210055161,-2.251159861,{"v":2.72748E-24,"d":"2.73E-24"},{"v":5.08902E-24,"d":"5.09E-24"},"down","yes","Tnk1","protein_coding","chr10:54571117-54579940:-","gi|564372754|ref|XP_006246767.1|",3389,0,"PREDICTED: non-receptor tyrosine-protein kinase TNK1 isoform X3 [Rattus norvegicus]","gi|672067912|ref|XM_006246705.2|",2902,0,"PREDICTED: Rattus norvegicus tyrosine kinase, non-receptor, 1 (Tnk1), transcript variant X3, mRNA","Q99ML2",1098,0,"Non-receptor tyrosine-protein kinase TNK1",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0030154|cell differentiation;GO:0030308|negative regulation of cell growth;GO:0045087|innate immune response;GO:0046580|negative regulation of Ras protein signal transduction;GO:0046777|protein autophosphorylation;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016020|membrane;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;","GO:0004713|protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0005102|signaling receptor binding;GO:0005524|ATP binding;","K08885","TNK1; non-receptor tyrosine-protein kinase TNK1 [EC:2.7.10.2]"]
["ENSRNOG00000013072",70,4.503130673,245,15.81765562,0.284690145,-1.812535541,{"v":2.80203e-24,"d":"2.80E-24"},{"v":5.21958E-24,"d":"5.22E-24"},"down","yes","Plxna4","protein_coding","chr4:60720255-61162206:-","gi|171543899|ref|NP_786926.2|",10117,0,"plexin-A4 precursor [Mus musculus]","gi|171543898|ref|NM_175750.3|",8819,0,"Mus musculus plexin A4 (Plxna4), mRNA","Q80UG2",3901,0,"Plexin-A4",".",".",".",".","pfam08337","Plexin_cytopl","Plexin cytoplasmic RasGAP domain. This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.","GO:0007162|negative regulation of cell adhesion;GO:0007399|nervous system development;GO:0007411|axon guidance;GO:0008045|motor neuron axon guidance;GO:0008360|regulation of cell shape;GO:0021602|cranial nerve morphogenesis;GO:0021610|facial nerve morphogenesis;GO:0021612|facial nerve structural organization;GO:0021615|glossopharyngeal nerve morphogenesis;GO:0021636|trigeminal nerve morphogenesis;GO:0021637|trigeminal nerve structural organization;GO:0021644|vagus nerve morphogenesis;GO:0021784|postganglionic parasympathetic fiber development;GO:0021785|branchiomotor neuron axon guidance;GO:0021793|chemorepulsion of branchiomotor axon;GO:0021960|anterior commissure morphogenesis;GO:0030334|regulation of cell migration;GO:0035050|embryonic heart tube development;GO:0043087|regulation of GTPase activity;GO:0048485|sympathetic nervous system development;GO:0048812|neuron projection morphogenesis;GO:0048841|regulation of axon extension involved in axon guidance;GO:0050772|positive regulation of axonogenesis;GO:0050923|regulation of negative chemotaxis;GO:0071526|semaphorin-plexin signaling pathway;GO:0097492|sympathetic neuron axon guidance;GO:1902287|semaphorin-plexin signaling pathway involved in axon guidance;","GO:0002116|semaphorin receptor complex;GO:0005887|integral component of plasma membrane;","GO:0017154|semaphorin receptor activity;","K06820","PLXNA; plexin A"]
["ENSRNOG00000064497",17,1.093617449,135,8.715851053,0.125474545,-2.994533375,{"v":3.03223E-24,"d":"3.03E-24"},{"v":5.64105e-24,"d":"5.64E-24"},"down","yes","Olr1585","protein_coding","chr13:86009008-86073347:+","gi|47576433|ref|NP_001001109.1|",1508,0,"olfactory receptor Olr1585 [Rattus norvegicus]","gi|672074948|ref|XM_008769791.1|",3320,0,"PREDICTED: Rattus norvegicus olfactory receptor 1587 (Olr1587), transcript variant X1, mRNA","P11369",222,{"v":2e-128,"d":"2.00E-128"},"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.",".",".",".",".","."]
["ENSRNOG00000014673",181,11.64380931,426,27.50335221,0.423359641,-1.240044352,{"v":4.15025e-24,"d":"4.15E-24"},{"v":7.69091e-24,"d":"7.69E-24"},"down","yes","Eri2","protein_coding","chr1:174141993-174168665:-","gi|300798138|ref|NP_001178043.1|",3609,0,"ERI1 exoribonuclease 2 [Rattus norvegicus]","gi|300798137|ref|NM_001191114.1|",3448,0,"Rattus norvegicus ERI1 exoribonuclease family member 2 (Eri2), mRNA","Q5BKS4",1239,0,"ERI1 exoribonuclease 2","SPBC30B4.08",101,{"v":4e-22,"d":"4.00E-22"},"COG5018","pfam00929","RNase_T","Exonuclease. This family includes a variety of exonuclease proteins, such as ribonuclease T and the epsilon subunit of DNA polymerase III.;","GO:0000467|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);",".","GO:0000175|3'-5'-exoribonuclease activity;GO:0003676|nucleic acid binding;GO:0008270|zinc ion binding;","K18417","ERI2; ERI1 exoribonuclease 2 [EC:3.1.-.-]"]
["ENSRNOG00000027940",87,5.596748122,274,17.68994955,0.316380107,-1.660269206,{"v":4.92039e-24,"d":"4.92E-24"},{"v":9.07977e-24,"d":"9.08E-24"},"down","yes","Plppr3","protein_coding","chr7:9831162-9845296:+","gi|767172187|ref|NP_853665.2|",3193,0,"phospholipid phosphatase-related protein type 3 [Rattus norvegicus]","gi|767172186|ref|NM_181634.3|",2415,0,"Rattus norvegicus phospholipid phosphatase related 3 (Plppr3), mRNA","Q7TMB0",1234,0,"Phospholipid phosphatase-related protein type 3",".",".",".",".","pfam01569","PAP2","PAP2 superfamily. This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidizing halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.","GO:0006644|phospholipid metabolic process;GO:0007165|signal transduction;GO:0016311|dephosphorylation;GO:0046839|phospholipid dephosphorylation;","GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;","GO:0008195|phosphatidate phosphatase activity;GO:0042577|lipid phosphatase activity;","K19582","LPPR3_4; lipid phosphate phosphatase-related protein type 3/4"]
["ENSRNOG00000030830",183,11.77247019,428,27.63247593,0.426037472,-1.230947767,{"v":5.92186e-24,"d":"5.92E-24"},{"v":1.09172E-23,"d":"1.09E-23"},"down","yes","Mex3d","protein_coding","chr7:9325488-9332096:+","gi|672057971|ref|XP_006241103.2|",2474,0,"PREDICTED: RNA-binding protein MEX3D isoform X2, partial [Rattus norvegicus]","gi|145651817|ref|NM_198615.2|",2145,0,"Mus musculus mex3 RNA binding family member D (Mex3d), mRNA","Q3UE17",729,0,"RNA-binding protein MEX3D",".",".",".",".","pfam13920","zf-C3HC4_3","Zinc finger, C3HC4 type (RING finger).",".","GO:0005634|nucleus;GO:0048471|perinuclear region of cytoplasm;","GO:0035925|mRNA 3'-UTR AU-rich region binding;GO:0046872|metal ion binding;","K15686","MEX3, RKHD; RNA-binding protein MEX3 [EC:2.3.2.27]"]
["ENSRNOG00000014227",2,0.128660876,94,6.068814808,0.02120033,-5.559769471,{"v":6.09371e-24,"d":"6.09E-24"},{"v":1.12196e-23,"d":"1.12E-23"},"down","yes","Mrgprx3","protein_coding","chr1:97721436-97746900:-","gi|59709471|ref|NP_665730.2|",1457,0,"mas-related G-protein coupled receptor member A [Rattus norvegicus]","gi|59709470|ref|NM_145787.2|",1285,0,"Rattus norvegicus MAS related GPR family member X3 (Mrgprx3), mRNA","Q7TN49",513,{"v":2E-180,"d":"2.00E-180"},"Mas-related G-protein coupled receptor member A",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0007218|neuropeptide signaling pathway;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0008188|neuropeptide receptor activity;","K08396","MRGPRX; Mas-related G protein-coupled receptor member X"]
["ENSRNOG00000016291",2,0.128660876,94,6.068814808,0.02120033,-5.559769471,{"v":6.09371e-24,"d":"6.09E-24"},{"v":1.12196e-23,"d":"1.12E-23"},"down","yes","Marveld3","protein_coding","chr19:37905638-37923420:-","gi|564395765|ref|XP_006255660.1|",1469,0,"PREDICTED: MARVEL domain-containing protein 3 isoform X1 [Rattus norvegicus]","gi|672084920|ref|XM_006255598.2|",1457,0,"PREDICTED: Rattus norvegicus MARVEL domain containing 3 (Marveld3), transcript variant X1, mRNA","Q9D956",520,{"v":3e-166,"d":"3.00E-166"},"MARVEL domain-containing protein 3",".",".",".",".","pfam01284","MARVEL","Membrane-associating domain. MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.","GO:0006970|response to osmotic stress;GO:0010633|negative regulation of epithelial cell migration;GO:0045216|cell-cell junction organization;GO:0046329|negative regulation of JNK cascade;GO:0050680|negative regulation of epithelial cell proliferation;GO:0070830|bicellular tight junction assembly;GO:1902414|protein localization to cell junction;","GO:0005737|cytoplasm;GO:0005923|bicellular tight junction;GO:0016021|integral component of membrane;GO:0031410|cytoplasmic vesicle;","GO:0031435|mitogen-activated protein kinase kinase kinase binding;","K21099","MARVELD3; MARVEL domain-containing protein 3"]
["ENSRNOG00000055650",16,1.029287011,130,8.393041755,0.122635755,-3.027548432,{"v":1.23039e-23,"d":"1.23E-23"},{"v":2.24437e-23,"d":"2.24E-23"},"down","yes","Pou2f2","protein_coding","chr1:80685741-80724261:-","gi|982316779|ref|XP_015297560.1|",1450,0,"PREDICTED: POU domain, class 2, transcription factor 2 isoform X11 [Macaca fascicularis]","gi|755519209|ref|XM_006539659.2|",2297,0,"PREDICTED: Mus musculus POU domain, class 2, transcription factor 2 (Pou2f2), transcript variant X14, mRNA","P09086",491,{"v":5e-157,"d":"5.00E-157"},"POU domain, class 2, transcription factor 2",".",".",".",".","pfam00157","Pou","Pou domain - N-terminal to homeobox domain.","GO:0002335|mature B cell differentiation;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0032755|positive regulation of interleukin-6 production;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048469|cell maturation;GO:0098586|cellular response to virus;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0043231|intracellular membrane-bounded organelle;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0019904|protein domain specific binding;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09364","POU2F, OTF; POU domain transcription factor, class 2"]
["ENSRNOG00000062297",18,1.157947887,135,8.715851053,0.132855401,-2.912071215,{"v":1.23134e-23,"d":"1.23E-23"},{"v":2.2454e-23,"d":"2.25E-23"},"down","yes","Klra5","protein_coding","chr4:164806003-164823382:-","gi|672051289|ref|XP_008761566.1|",1346,0,"PREDICTED: killer cell lectin-like receptor, subfamily A, member 5 isoform X3 [Rattus norvegicus]","gi|38454231|ref|NM_198746.1|",1128,0,"Rattus norvegicus killer cell lectin-like receptor, subfamily A, member 5 (Klra5), mRNA","Q60652",322,{"v":6e-107,"d":"6.00E-107"},"Killer cell lectin-like receptor 5",".",".",".",".","pfam08391","Ly49","Ly49-like protein, N-terminal region. The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).","GO:0030101|natural killer cell activation;","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000004198",122,7.848313459,330,21.30541369,0.368371794,-1.440765496,{"v":1.48018E-23,"d":"1.48E-23"},{"v":2.69142E-23,"d":"2.69E-23"},"down","yes","Stxbp6","protein_coding","chr6:61920756-62158024:-","gi|488584284|ref|XP_004477524.1|",860,{"v":1e-102,"d":"1.00E-102"},"PREDICTED: syntaxin-binding protein 6 isoform X1 [Dasypus novemcinctus]","gi|672056080|ref|XM_008764658.1|",3358,0,"PREDICTED: Rattus norvegicus syntaxin binding protein 6 (amisyn) (Stxbp6), transcript variant X2, mRNA","Q8R3T5",335,{"v":4e-104,"d":"4.00E-104"},"Syntaxin-binding protein 6",".",".",".",".","pfam15277","Sec3-PIP2_bind","Exocyst complex component SEC3 N-terminal PIP2 binding PH. This is the N-terminal domain of fungal and eukaryotic Sec3 proteins. Sec3 is a component of the exocyst complex that is involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.This N-terminal domain contains a cryptic pleckstrin homology (PH) fold, and all six positively charged lysine and arginine residues in the PH domain predicted to bind the PIP2 head group are conserved. The exocyst complex is essential for many exocytic events, by tethering vesicles at the plasma membrane for fusion. In fission yeast, polarised exocytosis for growth relies on the combined action of the exocyst at cell poles and myosin-driven transport along actin cables.","GO:0006887|exocytosis;GO:0006893|Golgi to plasma membrane transport;GO:0035493|SNARE complex assembly;GO:0035542|regulation of SNARE complex assembly;","GO:0000145|exocyst;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;","K08519","STXBP6; syntaxin-binding protein 6"]
["ENSRNOG00000011016",17,1.093617449,132,8.522165474,0.12832624,-2.962111897,{"v":1.64593e-23,"d":"1.65E-23"},{"v":2.99186e-23,"d":"2.99E-23"},"down","yes","Slc7a2","protein_coding","chr16:51417493-51470784:-","gi|672080252|ref|XP_008769503.1|",3258,0,"PREDICTED: low affinity cationic amino acid transporter 2 isoform X1 [Rattus norvegicus]","gi|402746476|ref|NM_001134686.2|",2482,0,"Rattus norvegicus solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 (Slc7a2), transcript variant 2, mRNA","B5D5N9",1212,0,"Cationic amino acid transporter 2","XF2207",238,{"v":6E-68,"d":"6.00E-68"},"COG0531","pfam13520","AA_permease_2","Amino acid permease.","GO:0002537|nitric oxide production involved in inflammatory response;GO:0006809|nitric oxide biosynthetic process;GO:0006865|amino acid transport;GO:0015807|L-amino acid transport;GO:0015809|arginine transport;GO:0042116|macrophage activation;GO:0043030|regulation of macrophage activation;GO:0050727|regulation of inflammatory response;GO:0089718|amino acid import across plasma membrane;GO:0097638|L-arginine import across plasma membrane;GO:0097639|L-lysine import across plasma membrane;GO:0097640|L-ornithine import across plasma membrane;GO:1902023|L-arginine transport;GO:1902475|L-alpha-amino acid transmembrane transport;GO:1903352|L-ornithine transmembrane transport;GO:1903401|L-lysine transmembrane transport;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030054|cell junction;","GO:0000064|L-ornithine transmembrane transporter activity;GO:0005289|high-affinity arginine transmembrane transporter activity;GO:0005292|high-affinity lysine transmembrane transporter activity;GO:0015171|amino acid transmembrane transporter activity;GO:0015179|L-amino acid transmembrane transporter activity;GO:0015181|arginine transmembrane transporter activity;GO:0015189|L-lysine transmembrane transporter activity;GO:0061459|L-arginine transmembrane transporter activity;GO:0097626|low-affinity L-arginine transmembrane transporter activity;GO:0097627|high-affinity L-ornithine transmembrane transporter activity;","K13864","SLC7A2, ATRC2; solute carrier family 7 (cationic amino acid transporter), member 2"]
["ENSRNOG00000054964",42,2.701878404,187,12.07306776,0.223793857,-2.159757656,{"v":2.16249e-23,"d":"2.16E-23"},{"v":3.91711e-23,"d":"3.92E-23"},"down","yes","Aoah","protein_coding","chr17:43809638-44049148:-","gi|300794357|ref|NP_001178869.1|",3043,0,"acyloxyacyl hydrolase precursor [Rattus norvegicus]","gi|300794356|ref|NM_001191940.1|",1747,0,"Rattus norvegicus acyloxyacyl hydrolase (neutrophil) (Aoah), mRNA","O35298",1080,0,"Acyloxyacyl hydrolase",".",".",".",".","pfam00657","Lipase_GDSL","GDSL-like Lipase/Acylhydrolase.","GO:0006631|fatty acid metabolic process;GO:0008653|lipopolysaccharide metabolic process;GO:0009104|lipopolysaccharide catabolic process;GO:0050728|negative regulation of inflammatory response;","GO:0005576|extracellular region;GO:0043231|intracellular membrane-bounded organelle;","GO:0005509|calcium ion binding;GO:0050528|acyloxyacyl hydrolase activity;","K01065","AOAH; acyloxyacyl hydrolase [EC:3.1.1.77]"]
["ENSRNOG00000016763",71,4.567461111,242,15.62397004,0.292336781,-1.774296737,{"v":2.36199e-23,"d":"2.36E-23"},{"v":4.27577e-23,"d":"4.28E-23"},"down","yes","Fgfr4","protein_coding","chr17:9461547-9476242:-","gi|158186625|ref|NP_001103374.1|",3761,0,"fibroblast growth factor receptor 4 precursor [Rattus norvegicus]","gi|71679848|gb|BC100260.1|",3228,0,"Rattus norvegicus fibroblast growth factor receptor 4, mRNA (cDNA clone MGC:116290 IMAGE:7100540), complete cds","Q498D6",1453,0,"Fibroblast growth factor receptor 4",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001759|organ induction;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007275|multicellular organism development;GO:0008284|positive regulation of cell proliferation;GO:0008543|fibroblast growth factor receptor signaling pathway;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010715|regulation of extracellular matrix disassembly;GO:0010966|regulation of phosphate transport;GO:0016477|cell migration;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0019216|regulation of lipid metabolic process;GO:0030324|lung development;GO:0033674|positive regulation of kinase activity;GO:0042593|glucose homeostasis;GO:0042632|cholesterol homeostasis;GO:0043085|positive regulation of catalytic activity;GO:0045862|positive regulation of proteolysis;GO:0046777|protein autophosphorylation;GO:0051174|regulation of phosphorus metabolic process;GO:0055062|phosphate ion homeostasis;GO:0061144|alveolar secondary septum development;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070640|vitamin D3 metabolic process;GO:0070857|regulation of bile acid biosynthetic process;GO:0090272|negative regulation of fibroblast growth factor production;GO:2000573|positive regulation of DNA biosynthetic process;GO:2000830|positive regulation of parathyroid hormone secretion;","GO:0005768|endosome;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005911|cell-cell junction;GO:0030133|transport vesicle;GO:0043235|receptor complex;","GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0005007|fibroblast growth factor-activated receptor activity;GO:0005524|ATP binding;GO:0008201|heparin binding;GO:0017134|fibroblast growth factor binding;","K05095","FGFR4, CD334; fibroblast growth factor receptor 4 [EC:2.7.10.1]"]
["ENSRNOG00000014835",34,2.187234898,170,10.97551614,0.199283102,-2.327108714,{"v":2.64825e-23,"d":"2.65E-23"},{"v":4.78639e-23,"d":"4.79E-23"},"down","yes","Il1rl1","protein_coding","chr9:42697192-42727256:+","gi|564367920|ref|XP_006244801.1|",3060,0,"PREDICTED: interleukin-1 receptor-like 1 isoform X1 [Rattus norvegicus]","gi|672064790|ref|XM_006244739.2|",2267,0,"PREDICTED: Rattus norvegicus interleukin 1 receptor-like 1 (Il1rl1), transcript variant X1, mRNA","Q62611",1181,0,"Interleukin-1 receptor-like 1",".",".",".",".","pfam01582","TIR","TIR domain. The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.","GO:0002826|negative regulation of T-helper 1 type immune response;GO:0008285|negative regulation of cell proliferation;GO:0019221|cytokine-mediated signaling pathway;GO:0031667|response to nutrient levels;GO:0032689|negative regulation of interferon-gamma production;GO:0032722|positive regulation of chemokine production;GO:0032754|positive regulation of interleukin-5 production;GO:0038172|interleukin-33-mediated signaling pathway;GO:0043032|positive regulation of macrophage activation;GO:0043124|negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0050729|positive regulation of inflammatory response;GO:0071260|cellular response to mechanical stimulus;GO:1901653|cellular response to peptide;","GO:0005615|extracellular space;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005925|focal adhesion;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0031012|extracellular matrix;","GO:0002113|interleukin-33 binding;GO:0002114|interleukin-33 receptor activity;GO:0003674|molecular_function;GO:0003953|NAD+ nucleosidase activity;GO:0004908|interleukin-1 receptor activity;GO:0050135|NAD(P)+ nucleosidase activity;GO:0061809|NAD+ nucleotidase, cyclic ADP-ribose generating;","K05171","IL1RL1, ST2; interleukin 1 receptor-like 1"]
["ENSRNOG00000015616",35,2.251565336,172,11.10463986,0.20275897,-2.302162357,{"v":2.81363e-23,"d":"2.81E-23"},{"v":5.08208e-23,"d":"5.08E-23"},"down","yes","Rgs14","protein_coding","chr17:9249019-9263104:-","gi|16758600|ref|NP_446216.1|",2628,0,"regulator of G-protein signaling 14 [Rattus norvegicus]","gi|16758599|ref|NM_053764.1|",2831,0,"Rattus norvegicus regulator of G-protein signaling 14 (Rgs14), mRNA","O08773",1016,0,"Regulator of G-protein signaling 14",".",".",".",".","pfam00615","RGS","Regulator of G protein signaling domain. RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.","GO:0000278|mitotic cell cycle;GO:0006913|nucleocytoplasmic transport;GO:0006979|response to oxidative stress;GO:0007051|spindle organization;GO:0007059|chromosome segregation;GO:0007612|learning;GO:0007616|long-term memory;GO:0008277|regulation of G protein-coupled receptor signaling pathway;GO:0008542|visual learning;GO:0010070|zygote asymmetric cell division;GO:0031914|negative regulation of synaptic plasticity;GO:0035556|intracellular signal transduction;GO:0043407|negative regulation of MAP kinase activity;GO:0043547|positive regulation of GTPase activity;GO:0043620|regulation of DNA-templated transcription in response to stress;GO:0045744|negative regulation of G protein-coupled receptor signaling pathway;GO:0048008|platelet-derived growth factor receptor signaling pathway;GO:0050769|positive regulation of neurogenesis;GO:0050804|modulation of chemical synaptic transmission;GO:0051301|cell division;GO:0060291|long-term synaptic potentiation;GO:0070373|negative regulation of ERK1 and ERK2 cascade;","GO:0000922|spindle pole;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0005819|spindle;GO:0005874|microtubule;GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0016604|nuclear body;GO:0016605|PML body;GO:0030425|dendrite;GO:0043197|dendritic spine;GO:0098978|glutamatergic synapse;","GO:0001965|G-protein alpha-subunit binding;GO:0005092|GDP-dissociation inhibitor activity;GO:0005096|GTPase activator activity;GO:0005515|protein binding;GO:0008017|microtubule binding;GO:0019901|protein kinase binding;GO:0030159|receptor signaling complex scaffold activity;GO:0032794|GTPase activating protein binding;","K17706","RGS14; regulator of G-protein signaling 14"]
["ENSRNOG00000059207",5,0.321652191,98,6.327062246,0.050837526,-4.297962369,{"v":3.72446e-23,"d":"3.72E-23"},{"v":6.70392e-23,"d":"6.70E-23"},"down","yes","Oas3","protein_coding","chr12:35779022-35802781:+","gi|57222314|ref|NP_001009493.1|",5928,0,"2'-5'-oligoadenylate synthase 3 [Rattus norvegicus]","gi|57222313|ref|NM_001009493.1|",4003,0,"Rattus norvegicus 2'-5'-oligoadenylate synthetase 3 (Oas3), mRNA","Q5MYT7",2288,0,"2'-5'-oligoadenylate synthase 3",".",".",".",".","pfam10421","OAS1_C","2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus. This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between 320 and 344 at the extreme C-terminal end. Oligoadenylate synthetases are antiviral enzymes that counteract vial attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesize 2'.5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication. This domain is often associated with NTP_transf_2 pfam01909.","GO:0009615|response to virus;GO:0032728|positive regulation of interferon-beta production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0035395|negative regulation of chemokine (C-X-C motif) ligand 9 production;GO:0039529|RIG-I signaling pathway;GO:0039530|MDA-5 signaling pathway;GO:0042742|defense response to bacterium;GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0051607|defense response to virus;GO:0060339|negative regulation of type I interferon-mediated signaling pathway;GO:0060700|regulation of ribonuclease activity;GO:0071639|positive regulation of monocyte chemotactic protein-1 production;GO:0071650|negative regulation of chemokine (C-C motif) ligand 5 production;GO:0071659|negative regulation of IP-10 production;GO:2000342|negative regulation of chemokine (C-X-C motif) ligand 2 production;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016020|membrane;","GO:0001730|2'-5'-oligoadenylate synthetase activity;GO:0003725|double-stranded RNA binding;GO:0005524|ATP binding;GO:0046872|metal ion binding;","K14216","OAS; 2'-5'-oligoadenylate synthetase [EC:2.7.7.84]"]
["ENSRNOG00000052064",52,3.345182786,205,13.23518123,0.2527493,-1.984221001,{"v":4.98651e-23,"d":"4.99E-23"},{"v":8.94176e-23,"d":"8.94E-23"},"down","yes","Parvg","protein_coding","chr7:115456209-115475104:+","gi|194474058|ref|NP_001124055.1|",1661,0,"gamma-parvin [Rattus norvegicus]","gi|194474057|ref|NM_001130583.1|",2536,0,"Rattus norvegicus parvin, gamma (Parvg), mRNA","Q9ERD8",592,0,"Gamma-parvin",".",".",".",".","pfam00307","CH","Calponin homology (CH) domain. The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.","GO:0007163|establishment or maintenance of cell polarity;GO:0030031|cell projection assembly;GO:0031532|actin cytoskeleton reorganization;GO:0034446|substrate adhesion-dependent cell spreading;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005925|focal adhesion;GO:0015629|actin cytoskeleton;","GO:0003779|actin binding;","K06275","PARV; parvin"]
["ENSRNOG00000002092",25,1.608260955,149,9.619717089,0.16718381,-2.58049295,{"v":5.03851e-23,"d":"5.04E-23"},{"v":9.02651e-23,"d":"9.03E-23"},"down","yes","Hunk","protein_coding","chr11:29640775-29757526:+","gi|300793913|ref|NP_001178591.1|",3495,0,"hormonally up-regulated neu tumor-associated kinase [Rattus norvegicus]","gi|568997542|ref|XR_384941.1|",2513,0,"PREDICTED: Mus musculus hormonally upregulated Neu-associated kinase (Hunk), transcript variant X1, misc_RNA","O88866",1313,0,"Hormonally up-regulated neu tumor-associated kinase",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006468|protein phosphorylation;GO:0035556|intracellular signal transduction;",".","GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;","K08797","HUNK; hormonally upregulated Neu-associated kinase [EC:2.7.11.1]"]
["ENSRNOG00000023428",63,4.052817606,225,14.52641842,0.278996342,-1.841681887,{"v":6.89841e-23,"d":"6.90E-23"},{"v":1.23276e-22,"d":"1.23E-22"},"down","yes","Pik3r5","protein_coding","chr10:53132603-53199374:+","gi|300794017|ref|NP_001178852.1|",4266,0,"phosphoinositide 3-kinase regulatory subunit 5 [Rattus norvegicus]","gi|672067999|ref|XM_006246770.2|",3176,0,"PREDICTED: Rattus norvegicus phosphoinositide-3-kinase, regulatory subunit 5 (Pik3r5), transcript variant X1, mRNA","Q5SW28",1546,0,"Phosphoinositide 3-kinase regulatory subunit 5",".",".",".",".","pfam10486","PI3K_1B_p101","Phosphoinositide 3-kinase gamma adapter protein p101 subunit. Class I PI3Ks are dual-specific lipid and protein kinases involved in numerous intracellular signaling pathways. Class IB PI3K, p110gamma, is mainly activated by seven-transmembrane G-protein-coupled receptors (GPCRs), through its regulatory subunit p101 and G-protein beta-gamma subunits.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0014065|phosphatidylinositol 3-kinase signaling;GO:0043406|positive regulation of MAP kinase activity;GO:0043551|regulation of phosphatidylinositol 3-kinase activity;GO:0051897|positive regulation of protein kinase B signaling;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005942|phosphatidylinositol 3-kinase complex;GO:0005944|phosphatidylinositol 3-kinase complex, class IB;GO:0016020|membrane;GO:0034451|centriolar satellite;","GO:0031683|G-protein beta/gamma-subunit complex binding;GO:0046935|1-phosphatidylinositol-3-kinase regulator activity;","K21290","PIK3R5_6; phosphoinositide-3-kinase regulatory subunit 5/6"]
["ENSRNOG00000039086",21,1.350939202,139,8.974098492,0.150537595,-2.731804269,{"v":7.44497e-23,"d":"7.44E-23"},{"v":1.32835e-22,"d":"1.33E-22"},"down","yes","Ccdc153","protein_coding","chr8:44577836-44584338:+","gi|62078635|ref|NP_001013975.1|",759,{"v":2E-95,"d":"2.00E-95"},"coiled-coil domain-containing protein 153 [Rattus norvegicus]","gi|62078634|ref|NM_001013953.1|",1362,0,"Rattus norvegicus coiled-coil domain containing 153 (Ccdc153), mRNA",".",".",".",".",".",".",".",".","pfam04012","PspA_IM30","PspA/IM30 family. This family includes PspA a protein that suppresses sigma54-dependent transcription. The PspA protein, a negative regulator of the Escherichia coli phage shock psp operon, is produced when virulence factors are exported through secretins in many Gram-negative pathogenic bacteria and its homologue in plants, VIPP1, plays a critical role in thylakoid biogenesis, essential for photosynthesis. Activation of transcription by the enhancer-dependent bacterial sigma(54) containing RNA polymerase occurs through ATP hydrolysis-driven protein conformational changes enabled by activator proteins that belong to the large AAA(+) mechanochemical protein family. It has been shown that PspA directly and specifically acts upon and binds to the AAA(+) domain of the PspF transcription activator.",".",".","GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000050426",4,0.257321753,94,6.068814808,0.04240066,-4.559769471,{"v":7.47647E-23,"d":"7.48E-23"},{"v":1.33272E-22,"d":"1.33E-22"},"down","yes","Dnah3","protein_coding","chr1:174306644-174479474:-","gi|564298257|ref|XP_006223532.1|",21046,0,"PREDICTED: dynein heavy chain 3, axonemal isoform X1 [Rattus norvegicus]","gi|672014190|ref|XM_008774647.1|",12475,0,"PREDICTED: Rattus norvegicus dynein, axonemal, heavy chain 3 (Dnah3), transcript variant X2, mRNA","Q8BW94",7626,0,"Dynein heavy chain 3, axonemal","YKR054c",632,{"v":1E-180,"d":"1.00E-180"},"COG5245","pfam03028","Dynein_heavy","Dynein heavy chain and region D6 of dynein motor. This family represents the C-terminal region of dynein heavy chain. The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained.",".",".",".",".","."]
["ENSRNOG00000024000",37,2.380226213,174,11.23376358,0.211881459,-2.23867075,{"v":8.48227e-23,"d":"8.48E-23"},{"v":1.5106e-22,"d":"1.51E-22"},"down","yes","Cd22","protein_coding","chr1:86117459-86132322:-","gi|157819397|ref|NP_001100973.1|",4489,0,"B-cell receptor CD22 precursor [Rattus norvegicus]","gi|157819396|ref|NM_001107503.1|",3690,0,"Rattus norvegicus CD22 molecule (Cd22), mRNA","P35329",1345,0,"B-cell receptor CD22",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0002638|negative regulation of immunoglobulin production;GO:0030100|regulation of endocytosis;GO:0030888|regulation of B cell proliferation;GO:0042113|B cell activation;GO:0050776|regulation of immune response;GO:0050849|negative regulation of calcium-mediated signaling;GO:0050859|negative regulation of B cell receptor signaling pathway;","GO:0005769|early endosome;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0032809|neuronal cell body membrane;GO:0055037|recycling endosome;","GO:0019903|protein phosphatase binding;GO:0033691|sialic acid binding;GO:0042609|CD4 receptor binding;","K06467","CD22, SIGLEC2; CD22 antigen"]
["ENSRNOG00000014653",80,5.146435055,255,16.46327421,0.312600944,-1.677605961,{"v":8.6353e-23,"d":"8.64E-23"},{"v":1.53737e-22,"d":"1.54E-22"},"down","yes","Arl11","protein_coding","chr15:35480018-35496596:+","gi|61740633|ref|NP_001013451.1|",810,{"v":2E-100,"d":"2.00E-100"},"ADP-ribosylation factor-like protein 11 [Rattus norvegicus]","gi|672078347|ref|XM_006252135.2|",2046,0,"PREDICTED: Rattus norvegicus ADP-ribosylation factor-like 11 (Arl11), transcript variant X1, mRNA","Q5BK71",316,{"v":6E-102,"d":"6.00E-102"},"ADP-ribosylation factor-like protein 11",".",".",".",".","pfam00025","Arf","ADP-ribosylation factor family. Pfam combines a number of different Prosite families together","GO:0002244|hematopoietic progenitor cell differentiation;GO:0006886|intracellular protein transport;GO:0016192|vesicle-mediated transport;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;","GO:0003924|GTPase activity;GO:0005525|GTP binding;","K07959","ARL11; ADP-ribosylation factor-like protein 11"]
["ENSRNOG00000067203",127,8.169965649,333,21.49909927,0.380014323,-1.3958743,{"v":1.00766E-22,"d":"1.01E-22"},{"v":1.7884e-22,"d":"1.79E-22"},"down","yes","B4galnt2","protein_coding","chr10:80802941-80857700:-","gi|564313298|ref|XP_006220879.1|",2634,0,"PREDICTED: beta-1,4 N-acetylgalactosaminyltransferase 2 isoform X1 [Rattus norvegicus]","gi|672025192|ref|XM_006220817.2|",1886,0,"PREDICTED: Rattus norvegicus beta-1,4-N-acetyl-galactosaminyl transferase 2 (B4galnt2), transcript variant X1, mRNA","Q09199",877,0,"Beta-1,4 N-acetylgalactosaminyltransferase 2",".",".",".",".","pfam00535","Glycos_transf_2","Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.",".",".",".",".","."]
["ENSRNOG00000018603",146,9.392243975,363,23.43595505,0.40076216,-1.319181798,{"v":1.01637E-22,"d":"1.02E-22"},{"v":1.80329E-22,"d":"1.80E-22"},"down","yes","Carns1","protein_coding","chr1:201459076-201469845:-","gi|392338030|ref|XP_003753423.1|",4096,0,"PREDICTED: LOW QUALITY PROTEIN: carnosine synthase 1 [Rattus norvegicus]","gi|672014555|ref|XM_003753375.3|",3585,0,"PREDICTED: Rattus norvegicus carnosine synthase 1 (Carns1), mRNA","Q6ZPS2",1411,0,"Carnosine synthase 1","mlr6296",90.5,{"v":5e-18,"d":"5.00E-18"},"COG0439","pfam13535","ATP-grasp_4","ATP-grasp domain. This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity.","GO:0035499|carnosine biosynthetic process;",".","GO:0005524|ATP binding;GO:0016887|ATPase activity;GO:0046872|metal ion binding;GO:0047730|carnosine synthase activity;","K14755","CRNS1, ATPGD1; carnosine synthase [EC:6.3.2.11]"]
["ENSRNOG00000029195",241,15.5036356,504,32.53917727,0.47646059,-1.069571207,{"v":1.2839E-22,"d":"1.28E-22"},{"v":2.27301e-22,"d":"2.27E-22"},"down","yes","Uba7","protein_coding","chr8:108665292-108674099:+","gi|564365408|ref|XP_006243803.1|",5231,0,"PREDICTED: ubiquitin-like modifier-activating enzyme 7 isoform X1 [Rattus norvegicus]","gi|672062911|ref|XM_006243741.2|",3163,0,"PREDICTED: Rattus norvegicus ubiquitin-like modifier activating enzyme 7 (Uba7), transcript variant X1, mRNA","P41226",1400,0,"Ubiquitin-like modifier-activating enzyme 7","YKL210w",700,0,"COG0476","pfam00899","ThiF","ThiF family. This family contains a repeated domain in ubiquitin activating enzyme E1 and members of the bacterial ThiF/MoeB/HesA family.","GO:0006464|cellular protein modification process;GO:0006974|cellular response to DNA damage stimulus;GO:0016567|protein ubiquitination;GO:0019941|modification-dependent protein catabolic process;GO:0032020|ISG15-protein conjugation;GO:0032446|protein modification by small protein conjugation;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0004839|ubiquitin activating enzyme activity;GO:0004842|ubiquitin-protein transferase activity;GO:0005524|ATP binding;GO:0019782|ISG15 activating enzyme activity;","K10698","UBE1L, UBA7; ubiquitin-activating enzyme E1-like [EC:6.2.1.45]"]
["ENSRNOG00000029029",29,1.865582707,156,10.07165011,0.185231088,-2.432601843,{"v":1.39532E-22,"d":"1.40E-22"},{"v":2.46951e-22,"d":"2.47E-22"},"down","yes","Cxadrl1","protein_coding","chr8:99565421-99590972:-","gi|672063050|ref|XP_008764761.1|",2073,0,"PREDICTED: coxsackie virus and adenovirus receptor-like 1 isoform X1 [Rattus norvegicus]","gi|672063049|ref|XM_008766539.1|",1633,0,"PREDICTED: Rattus norvegicus coxsackie virus and adenovirus receptor-like 1 (Cxadrl1), transcript variant X1, mRNA","Q5R764",192,{"v":9e-54,"d":"9.00E-54"},"Coxsackievirus and adenovirus receptor homolog",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000005687",0,0.032165219,95,6.133376667,0.005244292,-7.575036228,{"v":1.90082E-22,"d":"1.90E-22"},{"v":3.3455e-22,"d":"3.35E-22"},"down","yes","ENSRNOG00000005687","protein_coding","chrX:112314691-112375096:+","gi|82830409|ref|NP_001032633.1|",3059,0,"sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) [Rattus norvegicus]","gi|145286554|gb|EF494736.1|",3246,0,"Rattus norvegicus neutral cationic amino acid transporter B0,+ mRNA, complete cds","Q9JMA9",1111,0,"Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)","BH3439",190,{"v":1E-50,"d":"1.00E-50"},"COG0733","pfam00209","SNF","Sodium:neurotransmitter symporter family.","GO:0009636|response to toxic substance;GO:0032328|alanine transport;GO:0035725|sodium ion transmembrane transport;GO:0089718|amino acid import across plasma membrane;","GO:0005887|integral component of plasma membrane;GO:0031526|brush border membrane;","GO:0015293|symporter activity;GO:0022858|alanine transmembrane transporter activity;","K05047","SLC6A14; solute carrier family 6 (neurotransmitter transporter) member 14"]
["ENSRNOG00000029465",273,17.56220962,548,35.37989909,0.496389478,-1.010455561,{"v":2.03093e-22,"d":"2.03E-22"},{"v":3.5701E-22,"d":"3.57E-22"},"down","yes","Slc26a10","protein_coding","chr7:62995381-63004087:-","gi|260593702|ref|NP_001128067.2|",2925,0,"solute carrier family 26 member 10 [Rattus norvegicus]","gi|260593701|ref|NM_001134595.2|",2330,0,"Rattus norvegicus solute carrier family 26, member 10 (Slc26a10), mRNA","Q5EBI0",669,0,"Solute carrier family 26 member 10","aq_1268",146,{"v":5E-36,"d":"5.00E-36"},"COG0659","pfam00916","Sulfate_transp","Sulfate transporter family. Mutations in human SLC26A2 lead to several human diseases.","GO:0015701|bicarbonate transport;GO:0019532|oxalate transport;GO:1902358|sulfate transmembrane transport;GO:1902476|chloride transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0016323|basolateral plasma membrane;","GO:0008271|secondary active sulfate transmembrane transporter activity;GO:0015106|bicarbonate transmembrane transporter activity;GO:0015108|chloride transmembrane transporter activity;GO:0015116|sulfate transmembrane transporter activity;GO:0015301|anion:anion antiporter activity;GO:0019531|oxalate transmembrane transporter activity;","K14707","SLC26A10; solute carrier family 26, member 10"]
["ENSRNOG00000012575",2,0.128660876,87,5.61688179,0.022906104,-5.448124115,{"v":3.06585E-22,"d":"3.07E-22"},{"v":5.34983e-22,"d":"5.35E-22"},"down","yes","Fat2","protein_coding","chr10:39364073-39456216:-","gi|12621132|ref|NP_075243.1|",22867,0,"protocadherin Fat 2 precursor [Rattus norvegicus]","gi|12621131|ref|NM_022954.1|",14521,0,"Rattus norvegicus FAT atypical cadherin 2 (Fat2), mRNA","O88277",8812,0,"Protocadherin Fat 2",".",".",".",".","pfam00028","Cadherin","Cadherin domain.","GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0010631|epithelial cell migration;GO:0031589|cell-substrate adhesion;GO:0098609|cell-cell adhesion;","GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005912|adherens junction;GO:0016021|integral component of membrane;","GO:0005509|calcium ion binding;","K16506","FAT1_2_3; protocadherin Fat 1/2/3"]
["ENSRNOG00000025805",2,0.128660876,87,5.61688179,0.022906104,-5.448124115,{"v":3.06585E-22,"d":"3.07E-22"},{"v":5.34983e-22,"d":"5.35E-22"},"down","yes","Ms4a14","protein_coding","chr1:207949426-207964937:-","gi|149062445|gb|EDM12868.1|",5128,0,"rCG47812, isoform CRA_a [Rattus norvegicus]","gi|31342056|ref|NM_181082.2|",3764,0,"Rattus norvegicus membrane spanning 4-domains A14 (Ms4a14), mRNA","Q96JA4",282,{"v":4e-80,"d":"4.00E-80"},"Membrane-spanning 4-domains subfamily A member 14",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.",".","GO:0016021|integral component of membrane;",".","K22192","MS4A14; membrane-spanning 4-domains subfamily A member 14"]
["ENSRNOG00000068431",6,0.385982629,97,6.262500387,0.061633949,-4.020130961,{"v":3.74247e-22,"d":"3.74E-22"},{"v":6.51063e-22,"d":"6.51E-22"},"down","yes","Eppk1","protein_coding","chr7:107817693-107831159:-","gi|392341526|ref|XP_003754359.1|",16351,0,"PREDICTED: epiplakin isoform X1 [Rattus norvegicus]","gi|672022046|ref|XM_006226135.2|",9900,0,"PREDICTED: Rattus norvegicus epiplakin 1 (Eppk1), transcript variant X3, mRNA","Q8R0W0",5744,0,"Epiplakin",".",".",".",".","pfam00681","Plectin","Plectin repeat. This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.",".",".",".",".","."]
["ENSRNOG00000017878",37,2.380226213,171,11.040078,0.215598677,-2.213579769,{"v":3.80457e-22,"d":"3.80E-22"},{"v":6.61262e-22,"d":"6.61E-22"},"down","yes","ENSRNOG00000017878","protein_coding","chr1:218201472-218248906:-","gi|672014726|ref|XP_008773006.1|",2368,0,"PREDICTED: LOW QUALITY PROTEIN: aldehyde dehydrogenase, cytosolic 1 isoform X1 [Rattus norvegicus]","gi|672040029|ref|XM_008760315.1|",1099,0,"PREDICTED: Rattus norvegicus aldehyde dehydrogenase family 1, subfamily A7 (Aldh1a7), transcript variant X2, mRNA","P13601",874,0,"Aldehyde dehydrogenase, cytosolic 1","SPAC9E9.09c",449,{"v":4e-147,"d":"4.00E-147"},"COG1012","pfam00171","Aldedh","Aldehyde dehydrogenase family. This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:1.2.1.3. Succinate-semialdehyde dehydrogenase EC:1.2.1.16. Lactaldehyde dehydrogenase EC:1.2.1.22. Benzaldehyde dehydrogenase EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase EC: 1.5.1.12. Acetaldehyde dehydrogenase EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase EC:1.2.1.41. This family also includes omega crystallin, an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.","GO:0006068|ethanol catabolic process;GO:0035106|operant conditioning;","GO:0005829|cytosol;","GO:0004028|3-chloroallyl aldehyde dehydrogenase activity;GO:0004029|aldehyde dehydrogenase (NAD) activity;GO:0018479|benzaldehyde dehydrogenase (NAD+) activity;GO:0042802|identical protein binding;GO:0043878|glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity;GO:0051287|NAD binding;","K07249","ALDH1A; retinal dehydrogenase [EC:1.2.1.36]"]
["ENSRNOG00000005968",5,0.321652191,94,6.068814808,0.053000825,-4.237841376,{"v":3.99671e-22,"d":"4.00E-22"},{"v":6.94025e-22,"d":"6.94E-22"},"down","yes","Hoxa2","protein_coding","chr4:81262768-81265044:-","gi|488599464|ref|XP_004484860.1|",1530,0,"PREDICTED: homeobox protein Hox-A2 [Dasypus novemcinctus]","gi|672049746|ref|XM_008762936.1|",1634,0,"PREDICTED: Rattus norvegicus homeobox A2 (Hoxa2), mRNA","P31246",580,0,"Homeobox protein Hox-A2",".",".",".",".","pfam00046","Homeobox","Homeobox domain.",".",".",".","K09302","HOX_2; homeobox protein HoxA/B2"]
["ENSRNOG00000050898",0,0.032165219,93,6.004252948,0.005357073,-7.54433943,{"v":4.63804E-22,"d":"4.64E-22"},{"v":8.03923e-22,"d":"8.04E-22"},"down","yes","AABR07034730.2","protein_coding","chr11:81620545-81651699:+","gi|204856|gb|AAA51361.1|",562,{"v":3e-70,"d":"3.00E-70"},"productively rearranged V-lambda-2, partial [Rattus norvegicus]","gi|49615121|gb|AC109901.5|",456,0,"Rattus norvegicus 11 BAC CH230-280C3 (Children's Hospital Oakland Research Institute) complete sequence","P01721",124,{"v":3E-34,"d":"3.00E-34"},"Immunoglobulin lambda variable 6-57",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000001776",2,0.128660876,86,5.55231993,0.023172454,-5.431445374,{"v":5.38202e-22,"d":"5.38E-22"},{"v":9.3062e-22,"d":"9.31E-22"},"down","yes","Muc20","protein_coding","chr11:67987800-68001495:+","gi|564377098|ref|XP_006248511.1|",1733,0,"PREDICTED: mucin-20 isoform X1 [Rattus norvegicus]","gi|672071133|ref|XM_006248449.2|",2181,0,"PREDICTED: Rattus norvegicus mucin 20, cell surface associated (Muc20), transcript variant X1, mRNA","Q8BUE7",480,{"v":1e-157,"d":"1.00E-157"},"Mucin-20",".",".",".",".","pfam05109","Herpes_BLLF1","Herpes virus major outer envelope glycoprotein (BLLF1). This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralizing antibodies in vivo.","GO:0008150|biological_process;GO:0043410|positive regulation of MAPK cascade;GO:0048012|hepatocyte growth factor receptor signaling pathway;","GO:0005575|cellular_component;GO:0009925|basal plasma membrane;","GO:0003674|molecular_function;GO:0042802|identical protein binding;","K22021","MUC20; mucin-20"]
["ENSRNOG00000018018",27,1.736921831,149,9.619717089,0.180558515,-2.469461638,{"v":5.44881E-22,"d":"5.45E-22"},{"v":9.41883e-22,"d":"9.42E-22"},"down","yes","Kcnip2","protein_coding","chr1:244641150-244664874:-","gi|76881826|ref|NP_064479.2|",1367,0,"Kv channel-interacting protein 2 isoform a [Rattus norvegicus]","gi|672040609|ref|XM_008760479.1|",2343,0,"PREDICTED: Rattus norvegicus Kv channel-interacting protein 2-like (LOC100911951), transcript variant X1, mRNA","Q9JM59",531,0,"Kv channel-interacting protein 2","SPAC18B11.04",169,{"v":5e-47,"d":"5.00E-47"},"COG5126","pfam13499","EF-hand_7","EF-hand domain pair.","GO:0045163|clustering of voltage-gated potassium channels;GO:0086009|membrane repolarization;GO:0097623|potassium ion export across plasma membrane;GO:1901379|regulation of potassium ion transmembrane transport;GO:1903766|positive regulation of potassium ion export across plasma membrane;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0008076|voltage-gated potassium channel complex;GO:0030425|dendrite;","GO:0005250|A-type (transient outward) potassium channel activity;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0015459|potassium channel regulator activity;GO:0042802|identical protein binding;GO:0044325|ion channel binding;GO:0044877|protein-containing complex binding;GO:0047485|protein N-terminus binding;","K23855","KCNIP; Kv channel-interacting protein"]
["ENSRNOG00000005621",26,1.672591393,146,9.42603151,0.177443858,-2.49456546,{"v":8.22586e-22,"d":"8.23E-22"},{"v":1.4155e-21,"d":"1.42E-21"},"down","yes","Gxylt2","protein_coding","chr4:133347499-133449454:+","gi|568941620|ref|XP_006506070.1|",1724,0,"PREDICTED: glucoside xylosyltransferase 2 isoform X1 [Mus musculus]","gi|672050601|ref|XM_001066466.4|",1385,0,"PREDICTED: Rattus norvegicus glucoside xylosyltransferase 2 (Gxylt2), mRNA","Q810K9",646,0,"Glucoside xylosyltransferase 2",".",".",".",".","pfam01501","Glyco_transf_8","Glycosyl transferase family 8. This family includes enzymes that transfer sugar residues to donor molecules. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. This family includes Lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, and glycogenin glucosyltransferase.","GO:0016266|O-glycan processing;",".","GO:0035252|UDP-xylosyltransferase activity;","K13676","GXYLT; UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase [EC:2.4.2.42]"]
["ENSRNOG00000004754",139,8.941930908,346,22.33840344,0.400294091,-1.320867774,{"v":9.04273e-22,"d":"9.04E-22"},{"v":1.55419e-21,"d":"1.55E-21"},"down","yes","Tc2n","protein_coding","chr6:120761119-120849326:-","gi|68342017|ref|NP_001020323.1|",2419,0,"tandem C2 domains nuclear protein [Rattus norvegicus]","gi|672056732|ref|XM_008764834.1|",2396,0,"PREDICTED: Rattus norvegicus tandem C2 domains, nuclear (Tc2n), transcript variant X4, mRNA","Q91XT6",892,0,"Tandem C2 domains nuclear protein",".",".",".",".","pfam00168","C2","C2 domain.",".","GO:0005634|nucleus;",".","K17287","TC2N; tandem C2 domains nuclear protein"]
["ENSRNOG00000008346",0,0.032165219,91,5.875129229,0.00547481,-7.51297526,{"v":1.13626E-21,"d":"1.14E-21"},{"v":1.94881e-21,"d":"1.95E-21"},"down","yes","Itgb6","protein_coding","chr3:45048044-45121671:-","gi|51948494|ref|NP_001004263.1|",3951,0,"integrin beta-6 precursor [Rattus norvegicus]","gi|51948493|ref|NM_001004263.1|",2792,0,"Rattus norvegicus integrin subunit beta 6 (Itgb6), mRNA","Q6AYF4",1506,0,"Integrin beta-6",".",".",".",".","pfam00362","Integrin_beta","Integrin, beta chain. Integrins have been found in animals and their homologues have also been found in cyanobacteria, probably due to horizontal gene transfer. The sequences repeats have been trimmed due to an overlap with EGF.","GO:0000902|cell morphogenesis;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007160|cell-matrix adhesion;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0007229|integrin-mediated signaling pathway;GO:0008150|biological_process;GO:0009611|response to wounding;GO:0009615|response to virus;GO:0010467|gene expression;GO:0016477|cell migration;GO:0033627|cell adhesion mediated by integrin;GO:0042060|wound healing;GO:0043129|surfactant homeostasis;GO:0043588|skin development;GO:0048286|lung alveolus development;GO:0055091|phospholipid homeostasis;GO:0060022|hard palate development;GO:0060348|bone development;GO:0060395|SMAD protein signal transduction;GO:0060435|bronchiole development;GO:0061520|Langerhans cell differentiation;GO:0070166|enamel mineralization;GO:0071479|cellular response to ionizing radiation;GO:0071604|transforming growth factor beta production;GO:1901388|regulation of transforming growth factor beta activation;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005813|centrosome;GO:0005925|focal adhesion;GO:0008305|integrin complex;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0030054|cell junction;GO:0034685|integrin alphav-beta6 complex;GO:0043235|receptor complex;","GO:0003674|molecular_function;GO:0005178|integrin binding;GO:0038023|signaling receptor activity;","K06589","ITGB6; integrin beta 6"]
["ENSRNOG00000001806",21,1.350939202,134,8.651289194,0.156154669,-2.678952387,{"v":1.14066e-21,"d":"1.14E-21"},{"v":1.95576e-21,"d":"1.96E-21"},"down","yes","Fetub","protein_coding","chr11:78082156-78095135:-","gi|564377401|ref|XP_006248611.1|",1906,0,"PREDICTED: fetuin-B isoform X1 [Rattus norvegicus]","gi|564377400|ref|XM_006248549.1|",1344,0,"PREDICTED: Rattus norvegicus fetuin B (Fetub), transcript variant X1, mRNA","Q9QX79",702,0,"Fetuin-B",".",".",".",".","pfam00031","Cystatin","Cystatin domain. Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 are related to this family but have not been included.","GO:0007338|single fertilization;GO:0007339|binding of sperm to zona pellucida;GO:0010951|negative regulation of endopeptidase activity;","GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0004866|endopeptidase inhibitor activity;GO:0004869|cysteine-type endopeptidase inhibitor activity;GO:0008191|metalloendopeptidase inhibitor activity;","K23411","FETUB; fetuin-B"]
["ENSRNOG00000030387",22,1.41526964,136,8.780412913,0.161184862,-2.633211842,{"v":1.35766e-21,"d":"1.36E-21"},{"v":2.32226e-21,"d":"2.32E-21"},"down","yes","Kng1","protein_coding","chr11:77812752-77835555:-","gi|149019923|gb|EDL78071.1|",2354,0,"rCG36716, isoform CRA_d [Rattus norvegicus]","gi|57526867|ref|NM_001009628.1|",1285,0,"Rattus norvegicus kininogen 1-like 1 (Kng1l1), mRNA","P08934",907,0,"Kininogen-1",".",".",".",".","pfam00031","Cystatin","Cystatin domain. Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 are related to this family but have not been included.","GO:0001938|positive regulation of endothelial cell proliferation;GO:0002542|Factor XII activation;GO:0006953|acute-phase response;GO:0006954|inflammatory response;GO:0007162|negative regulation of cell adhesion;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007596|blood coagulation;GO:0010951|negative regulation of endopeptidase activity;GO:0030195|negative regulation of blood coagulation;GO:0031640|killing of cells of other organism;GO:0042130|negative regulation of T cell proliferation;GO:0042311|vasodilation;GO:0043407|negative regulation of MAP kinase activity;GO:0043410|positive regulation of MAPK cascade;GO:0045861|negative regulation of proteolysis;GO:0048146|positive regulation of fibroblast proliferation;GO:0050672|negative regulation of lymphocyte proliferation;GO:0052548|regulation of endopeptidase activity;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0043204|perikaryon;GO:0043231|intracellular membrane-bounded organelle;","GO:0002020|protease binding;GO:0004866|endopeptidase inhibitor activity;GO:0004869|cysteine-type endopeptidase inhibitor activity;GO:0005102|signaling receptor binding;","K03898","KNG, BK; kininogen"]
["ENSRNOG00000003305",10,0.643304382,106,6.843557123,0.094001463,-3.411172979,{"v":1.43041E-21,"d":"1.43E-21"},{"v":2.44523e-21,"d":"2.45E-21"},"down","yes","Cxcr3","protein_coding","chrX:66844318-66846969:-","gi|16758152|ref|NP_445867.1|",1397,0,"C-X-C chemokine receptor type 3 [Rattus norvegicus]","gi|16758151|ref|NM_053415.1|",1504,0,"Rattus norvegicus chemokine (C-X-C motif) receptor 3 (Cxcr3), mRNA","Q9JII9",542,0,"C-X-C chemokine receptor type 3",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001525|angiogenesis;GO:0001937|negative regulation of endothelial cell proliferation;GO:0002685|regulation of leukocyte migration;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007166|cell surface receptor signaling pathway;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0008284|positive regulation of cell proliferation;GO:0010818|T cell chemotaxis;GO:0016525|negative regulation of angiogenesis;GO:0019722|calcium-mediated signaling;GO:0030155|regulation of cell adhesion;GO:0045766|positive regulation of angiogenesis;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050921|positive regulation of chemotaxis;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;GO:0060326|cell chemotaxis;GO:0070098|chemokine-mediated signaling pathway;GO:1900118|negative regulation of execution phase of apoptosis;GO:1900119|positive regulation of execution phase of apoptosis;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0016493|C-C chemokine receptor activity;GO:0016494|C-X-C chemokine receptor activity;GO:0019956|chemokine binding;GO:0019957|C-C chemokine binding;GO:0019958|C-X-C chemokine binding;GO:0038023|signaling receptor activity;","K04188","CXCR3, GPR9, CD183; C-X-C chemokine receptor type 3"]
["ENSRNOG00000010886",2,0.128660876,84,5.423196211,0.023724179,-5.397498042,{"v":1.66237e-21,"d":"1.66E-21"},{"v":2.83243e-21,"d":"2.83E-21"},"down","yes","Nfe2l3","protein_coding","chr4:80506756-80534629:+","gi|758818546|ref|NP_001291976.1|",3031,0,"nuclear factor erythroid 2-related factor 3 precursor [Rattus norvegicus]","gi|758818545|ref|NM_001305047.1|",2389,0,"Rattus norvegicus nuclear factor, erythroid 2-like 3 (Nfe2l3), mRNA","Q9WTM4",967,0,"Nuclear factor erythroid 2-related factor 3",".",".",".",".","pfam03131","bZIP_Maf","bZIP Maf transcription factor. Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerization and DNA binding property. Thus, this family is probably related to pfam00170. This family also includes the DNA_binding domain of Skn-1, this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;","K09040","NFE2L1_3; nuclear factor erythroid 2-related factor 1/3"]
["ENSRNOG00000027319",6,0.385982629,94,6.068814808,0.06360099,-3.97480697,{"v":2.22441e-21,"d":"2.22E-21"},{"v":3.77654e-21,"d":"3.78E-21"},"down","yes","Ephx3","protein_coding","chr7:11206812-11212122:-","gi|157823285|ref|NP_001102458.1|",1881,0,"epoxide hydrolase 3 [Rattus norvegicus]","gi|157823284|ref|NM_001108988.1|",1607,0,"Rattus norvegicus epoxide hydrolase 3 (Ephx3), mRNA","Q3V1F8",554,0,"Epoxide hydrolase 3",".",".",".",".","pfam12697","Abhydrolase_6","Alpha/beta hydrolase family. This family contains alpha/beta hydrolase enzymes of diverse specificity.","GO:0008150|biological_process;GO:0097176|epoxide metabolic process;","GO:0005575|cellular_component;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0003674|molecular_function;GO:0004301|epoxide hydrolase activity;GO:0016787|hydrolase activity;","K22368","EPHX3; epoxide hydrolase 3 [EC:3.3.2.10]"]
["ENSRNOG00000054033",54,3.473843662,200,12.91237193,0.269032187,-1.894149307,{"v":2.95909e-21,"d":"2.96E-21"},{"v":5.01046e-21,"d":"5.01E-21"},"down","yes","Adap1","protein_coding","chr12:15324209-15380831:+","gi|19424252|ref|NP_598251.1|",1898,0,"arf-GAP with dual PH domain-containing protein 1 [Rattus norvegicus]","gi|76496483|ref|NM_133567.2|",2196,0,"Rattus norvegicus ArfGAP with dual PH domains 1 (Adap1), mRNA","O75689",698,0,"Arf-GAP with dual PH domain-containing protein 1","SPAC824.09c",71.2,{"v":2E-12,"d":"2.00E-12"},"COG5347","pfam01412","ArfGap","Putative GTPase activating protein for Arf. Putative zinc fingers with GTPase activating proteins (GAPs) towards the small GTPase, Arf. The GAP of ARD1 stimulates GTPase hydrolysis for ARD1 but not ARFs.","GO:0043087|regulation of GTPase activity;GO:0043547|positive regulation of GTPase activity;GO:0048016|inositol phosphate-mediated signaling;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0005096|GTPase activator activity;GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;GO:1902936|phosphatidylinositol bisphosphate binding;","K23781","ADAP, CENTA; Arf-GAP with dual PH domain-containing protein"]
["ENSRNOG00000003464",211,13.57372246,450,29.05283684,0.46720816,-1.097862622,{"v":3.52837e-21,"d":"3.53E-21"},{"v":5.96732e-21,"d":"5.97E-21"},"down","yes","Hid1","protein_coding","chr10:100589555-100610041:-","gi|747811827|ref|NP_001291219.1|",4008,0,"HID1 domain containing [Rattus norvegicus]","gi|747811826|ref|NM_001304290.1|",3232,0,"Rattus norvegicus HID1 domain containing (Hid1), mRNA","Q8R1F6",1529,0,"Protein HID1",".",".",".",".","pfam12722","Hid1","High-temperature-induced dauer-formation protein. Hid1 (high-temperature-induced dauer-formation protein 1) represents proteins of approximately 800 residues long and is conserved from fungi to humans. It contains up to seven potential transmembrane domains separated by regions of low complexity. Functionally it might be involved in vesicle secretion or be an inter-cellular signalling protein or be a novel insulin receptor.","GO:0008150|biological_process;","GO:0000138|Golgi trans cisterna;GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005797|Golgi medial cisterna;GO:0005829|cytosol;GO:0005881|cytoplasmic microtubule;GO:0016020|membrane;GO:0090498|extrinsic component of Golgi membrane;","GO:0003674|molecular_function;",".","."]
["ENSRNOG00000004158",32,2.058574022,156,10.07165011,0.204392925,-2.290582838,{"v":3.84202e-21,"d":"3.84E-21"},{"v":6.48434e-21,"d":"6.48E-21"},"down","yes","Hdac9","protein_coding","chr6:50763590-51625333:-","gi|672055858|ref|XP_008762835.1|",2136,0,"PREDICTED: histone deacetylase 9 isoform X4 [Rattus norvegicus]","gi|672055857|ref|XM_008764613.1|",3831,0,"PREDICTED: Rattus norvegicus histone deacetylase 9 (Hdac9), transcript variant X4, mRNA","Q99N13",504,{"v":2e-158,"d":"2.00E-158"},"Histone deacetylase 9",".",".",".",".","pfam12203","HDAC4_Gln","Glutamine rich N terminal domain of histone deacetylase 4. This domain is found in eukaryotes, and is approximately 90 amino acids in length. The family is found in association with pfam00850. The domain forms an alpha helix which complexes to form a tetramer. The glutamine rich domains have many intra- and inter-helical interactions which are thought to be involved in reversible assembly and disassembly of proteins. The domain is part of histone deacetylase 4 (HDAC4) which removes acetyl groups from histones. This restores their positive charge to allow stronger DNA binding thus restricting transcriptional activity.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001818|negative regulation of cytokine production;GO:0001975|response to amphetamine;GO:0006281|DNA repair;GO:0007507|heart development;GO:0008340|determination of adult lifespan;GO:0016575|histone deacetylation;GO:0030182|neuron differentiation;GO:0032869|cellular response to insulin stimulus;GO:0034983|peptidyl-lysine deacetylation;GO:0042632|cholesterol homeostasis;GO:0045892|negative regulation of transcription, DNA-templated;GO:0048742|regulation of skeletal muscle fiber development;GO:0051005|negative regulation of lipoprotein lipase activity;GO:0051153|regulation of striated muscle cell differentiation;GO:0070932|histone H3 deacetylation;GO:0070933|histone H4 deacetylation;GO:0090050|positive regulation of cell migration involved in sprouting angiogenesis;GO:1990678|histone H4-K16 deacetylation;","GO:0000118|histone deacetylase complex;GO:0005634|nucleus;GO:0005667|transcription factor complex;GO:0005737|cytoplasm;GO:0035097|histone methyltransferase complex;","GO:0003674|molecular_function;GO:0003714|transcription corepressor activity;GO:0004407|histone deacetylase activity;GO:0005080|protein kinase C binding;GO:0032041|NAD-dependent histone deacetylase activity (H3-K14 specific);GO:0033558|protein deacetylase activity;GO:0034739|histone deacetylase activity (H4-K16 specific);GO:0042826|histone deacetylase binding;GO:0046872|metal ion binding;","K11409","HDAC9; histone deacetylase 9 [EC:3.5.1.98]"]
["ENSRNOG00000014285",71,4.567461111,230,14.84922772,0.307589135,-1.700923551,{"v":4.33446e-21,"d":"4.33E-21"},{"v":7.30034e-21,"d":"7.30E-21"},"down","yes","Ssh2","protein_coding","chr10:62057044-62306563:+","gi|564373228|ref|XP_006246967.1|",7239,0,"PREDICTED: protein phosphatase Slingshot homolog 2 isoform X1 [Rattus norvegicus]","gi|672068576|ref|XM_006246905.2|",6259,0,"PREDICTED: Rattus norvegicus slingshot protein phosphatase 2 (Ssh2), transcript variant X1, mRNA","Q5SW75",2554,0,"Protein phosphatase Slingshot homolog 2","SPBC17A3.06",83.2,{"v":8e-16,"d":"8.00E-16"},"COG2453","pfam00782","DSPc","Dual specificity phosphatase, catalytic domain. Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a \"recognition\" region.","GO:0006470|protein dephosphorylation;GO:0030036|actin cytoskeleton organization;GO:0030335|positive regulation of cell migration;GO:0030837|negative regulation of actin filament polymerization;GO:0035335|peptidyl-tyrosine dephosphorylation;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;","GO:0003779|actin binding;GO:0004721|phosphoprotein phosphatase activity;GO:0004725|protein tyrosine phosphatase activity;GO:0008138|protein tyrosine/serine/threonine phosphatase activity;","K05766","SSH; protein phosphatase slingshot [EC:3.1.3.16 3.1.3.48]"]
["ENSRNOG00000008588",17,1.093617449,122,7.876546878,0.138844784,-2.848455116,{"v":4.44417e-21,"d":"4.44E-21"},{"v":7.47849e-21,"d":"7.48E-21"},"down","yes","Batf","protein_coding","chr6:105353715-105376051:+","gi|148670929|gb|EDL02876.1|",818,{"v":3e-106,"d":"3.00E-106"},"basic leucine zipper transcription factor, ATF-like, partial [Mus musculus]","gi|672056489|ref|XM_008764758.1|",969,0,"PREDICTED: Rattus norvegicus basic leucine zipper transcription factor, ATF-like (Batf), transcript variant X1, mRNA","D4A7E1",219,{"v":1e-69,"d":"1.00E-69"},"Basic leucine zipper transcriptional factor ATF-like",".",".",".",".","pfam07716","bZIP_2","Basic region leucine zipper.","GO:0001819|positive regulation of cytokine production;GO:0002320|lymphoid progenitor cell differentiation;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006974|cellular response to DNA damage stimulus;GO:0008150|biological_process;GO:0030330|DNA damage response, signal transduction by p53 class mediator;GO:0042832|defense response to protozoan;GO:0043011|myeloid dendritic cell differentiation;GO:0045064|T-helper 2 cell differentiation;GO:0045190|isotype switching;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0060218|hematopoietic stem cell differentiation;GO:0072539|T-helper 17 cell differentiation;GO:0072540|T-helper 17 cell lineage commitment;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003700|DNA-binding transcription factor activity;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09034","BATF; ATF-like basic leucine zipper transcriptional factor"]
["ENSRNOG00000066184",1,0.064330438,82,5.294072492,0.012151409,-6.362732624,{"v":6.32554e-21,"d":"6.33E-21"},{"v":1.05913E-20,"d":"1.06E-20"},"down","yes","ENSRNOG00000066184","lncRNA","chr5:128148023-128154448:-",".",".",".",".","gi|21621618|emb|AL646006.17|",698,0,"Mouse DNA sequence from clone RP23-168C23 on chromosome 4, complete sequence",".",".",".",".",".",".",".",".","pfam13639","zf-RING_2","Ring finger domain.",".",".",".",".","."]
["ENSRNOG00000003108",187,12.02979194,412,26.59948618,0.452256553,-1.144786687,{"v":8.9225e-21,"d":"8.92E-21"},{"v":1.48829E-20,"d":"1.49E-20"},"down","yes","Acbd4","protein_coding","chr10:88048108-88058500:+","gi|672069510|ref|XP_008766508.1|",1323,{"v":3E-171,"d":"3.00E-171"},"PREDICTED: acyl-CoA-binding domain-containing protein 4 isoform X3 [Rattus norvegicus]","gi|672069505|ref|XM_008768284.1|",1171,0,"PREDICTED: Rattus norvegicus acyl-CoA binding domain containing 4 (Acbd4), transcript variant X1, mRNA","Q6DGF9",512,{"v":3e-172,"d":"3.00E-172"},"Acyl-CoA-binding domain-containing protein 4","RSc1366",62,{"v":3E-10,"d":"3.00E-10"},"COG4281","pfam00887","ACBP","Acyl CoA binding protein.",".",".","GO:0000062|fatty-acyl-CoA binding;GO:0008289|lipid binding;",".","."]
["ENSRNOG00000029964",2,0.128660876,81,5.229510632,0.024602852,-5.345030622,{"v":9.07633e-21,"d":"9.08E-21"},{"v":1.5113e-20,"d":"1.51E-20"},"down","yes","Tmprss11g","protein_coding","chr14:21546189-21587258:+","gi|56676362|ref|NP_001008554.1|",2131,0,"transmembrane protease serine 11G [Rattus norvegicus]","gi|56676361|ref|NM_001008554.1|",2683,0,"Rattus norvegicus transmembrane protease, serine 11G (Tmprss11g), mRNA","Q5QSK2",825,0,"Transmembrane protease serine 11G","VC1200",119,{"v":2e-27,"d":"2.00E-27"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;","GO:0005576|extracellular region;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;","GO:0004252|serine-type endopeptidase activity;","K18769","TMPRSS11G; transmembrane protease serine 11G [EC:3.4.21.-]"]
["ENSRNOG00000017680",26,1.672591393,141,9.103222211,0.183736193,-2.444292254,{"v":1.1408E-20,"d":"1.14E-20"},{"v":1.89347e-20,"d":"1.89E-20"},"down","yes","Dennd2d","protein_coding","chr2:193973231-193992270:+","gi|672043761|ref|XP_008759619.1|",2574,0,"PREDICTED: DENN domain-containing protein 2D isoform X2 [Rattus norvegicus]","gi|672043760|ref|XM_008761397.1|",2323,0,"PREDICTED: Rattus norvegicus DENN/MADD domain containing 2D (Dennd2d), transcript variant X2, mRNA","Q91VV4",766,0,"DENN domain-containing protein 2D",".",".",".",".","pfam02141","DENN","DENN (AEX-3) domain. DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.","GO:0050790|regulation of catalytic activity;","GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0005085|guanyl-nucleotide exchange factor activity;","K20161","DENND2; DENN domain-containing protein 2"]
["ENSRNOG00000014686",22,1.41526964,132,8.522165474,0.166069251,-2.59014312,{"v":1.17082E-20,"d":"1.17E-20"},{"v":1.94162E-20,"d":"1.94E-20"},"down","yes","Kcnd3","protein_coding","chr2:192937950-193155345:+","gi|401461798|ref|NP_001257891.1|",3118,0,"potassium voltage-gated channel subfamily D member 3 isoform 1 precursor [Rattus norvegicus]","gi|401461797|ref|NM_001270962.1|",6818,0,"Rattus norvegicus potassium voltage-gated channel subfamily D member 3 (Kcnd3), transcript variant 1, mRNA","Q62897",1202,0,"Potassium voltage-gated channel subfamily D member 3","MA2034",98.2,{"v":9e-21,"d":"9.00E-21"},"COG1226","pfam02214","BTB_2","BTB/POZ domain. In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.","GO:0006813|potassium ion transport;GO:0034765|regulation of ion transmembrane transport;GO:0051260|protein homooligomerization;GO:0071773|cellular response to BMP stimulus;GO:0071805|potassium ion transmembrane transport;GO:0086002|cardiac muscle cell action potential involved in contraction;GO:0086009|membrane repolarization;GO:0086065|cell communication involved in cardiac conduction;GO:0086091|regulation of heart rate by cardiac conduction;GO:0097623|potassium ion export across plasma membrane;GO:0098915|membrane repolarization during ventricular cardiac muscle cell action potential;GO:0099625|ventricular cardiac muscle cell membrane repolarization;GO:1990573|potassium ion import across plasma membrane;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005901|caveola;GO:0008076|voltage-gated potassium channel complex;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0034705|potassium channel complex;GO:0042383|sarcolemma;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043197|dendritic spine;GO:0045211|postsynaptic membrane;GO:0097038|perinuclear endoplasmic reticulum;GO:0098982|GABA-ergic synapse;GO:0099060|integral component of postsynaptic specialization membrane;","GO:0005216|ion channel activity;GO:0005249|voltage-gated potassium channel activity;GO:0005250|A-type (transient outward) potassium channel activity;GO:0005267|potassium channel activity;GO:0005515|protein binding;GO:0044325|ion channel binding;GO:0046872|metal ion binding;GO:0086008|voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization;GO:1902282|voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization;","K04893","KCND3, KV4.3; potassium voltage-gated channel Shal-related subfamily D member 3"]
["ENSRNOG00000061530",6,0.385982629,91,5.875129229,0.065697726,-3.928012759,{"v":1.32226E-20,"d":"1.32E-20"},{"v":2.18894e-20,"d":"2.19E-20"},"down","yes","ENSRNOG00000061530","protein_coding","chrX:70817433-70878717:+","gi|11177916|ref|NP_068639.1|",1086,{"v":2e-143,"d":"2.00E-143"},"fibroblast growth factor 16 [Rattus norvegicus]","gi|55250401|gb|BC085738.1|",1630,0,"Rattus norvegicus fibroblast growth factor 16, mRNA (cDNA clone MGC:93457 IMAGE:7189721), complete cds","O54769",422,{"v":6e-145,"d":"6.00E-145"},"Fibroblast growth factor 16",".",".",".",".","pfam00167","FGF","Fibroblast growth factor. Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide range of contexts. They are found in a wide range of organisms, from nematodes to humans. Most share an internal core region of high similarity, conserved residues in which are involved in binding with their receptors. On binding, they cause dimerization of their tyrosine kinase receptors leading to intracellular signalling. There are currently four known tyrosine kinase receptors for fibroblast growth factors. These receptors can each bind several different members of this family. Members of this family have a beta trefoil structure. Most have N-terminal signal peptides and are secreted. A few lack signal sequences but are secreted anyway; still others also lack the signal peptide but are found on the cell surface and within the extracellular matrix. A third group remain intracellular. They have central roles in development, regulating cell proliferation, migration and differentiation. On the other hand, they are important in tissue repair following injury in adult organisms.","GO:0001934|positive regulation of protein phosphorylation;GO:0008284|positive regulation of cell proliferation;GO:0008543|fibroblast growth factor receptor signaling pathway;GO:0009887|animal organ morphogenesis;GO:0010628|positive regulation of gene expression;GO:0030154|cell differentiation;GO:0030334|regulation of cell migration;GO:0070349|positive regulation of brown fat cell proliferation;GO:2000546|positive regulation of endothelial cell chemotaxis to fibroblast growth factor;","GO:0005615|extracellular space;GO:0005737|cytoplasm;","GO:0005104|fibroblast growth factor receptor binding;GO:0008083|growth factor activity;","K04358","FGF; fibroblast growth factor"]
["ENSRNOG00000004402",121,7.78398302,310,20.01417649,0.388923472,-1.362441787,{"v":1.49629e-20,"d":"1.50E-20"},{"v":2.46916e-20,"d":"2.47E-20"},"down","yes","Lpgat1","protein_coding","chr13:103294528-103362333:+","gi|672075206|ref|XP_008768097.1|",2083,0,"PREDICTED: acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X1 [Rattus norvegicus]","gi|672075205|ref|XM_008769875.1|",3814,0,"PREDICTED: Rattus norvegicus lysophosphatidylglycerol acyltransferase 1 (Lpgat1), transcript variant X1, mRNA","Q91YX5",762,0,"Acyl-CoA:lysophosphatidylglycerol acyltransferase 1","SPBC428.14",61.2,9e-09,"COG0204","pfam01553","Acyltransferase","Acyltransferase. This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.","GO:0019432|triglyceride biosynthetic process;GO:0036149|phosphatidylinositol acyl-chain remodeling;GO:0045723|positive regulation of fatty acid biosynthetic process;","GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0012505|endomembrane system;GO:0016021|integral component of membrane;","GO:0003846|2-acylglycerol O-acyltransferase activity;GO:0016746|transferase activity, transferring acyl groups;GO:0071617|lysophospholipid acyltransferase activity;","K13514","LPGAT1; lysophosphatidylglycerol acyltransferase 1 [EC:2.3.1.-]"]
["ENSRNOG00000008525",0,0.032165219,85,5.487758071,0.005861268,-7.414571555,{"v":1.71316e-20,"d":"1.71E-20"},{"v":2.82215e-20,"d":"2.82E-20"},"down","yes","Csf3","protein_coding","chr10:83661207-83663603:+","gi|149054126|gb|EDM05943.1|",815,{"v":6e-104,"d":"6.00E-104"},"colony stimulating factor 3 (granulocyte) [Rattus norvegicus]","gi|815890898|ref|NM_017104.2|",1297,0,"Rattus norvegicus colony stimulating factor 3 (Csf3), mRNA","P09920",269,{"v":3e-86,"d":"3.00E-86"},"Granulocyte colony-stimulating factor",".",".",".",".","pfam00489","IL6","Interleukin-6/G-CSF/MGF family.","GO:0006955|immune response;GO:0007165|signal transduction;GO:0008284|positive regulation of cell proliferation;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0030838|positive regulation of actin filament polymerization;GO:0032092|positive regulation of protein binding;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0045471|response to ethanol;GO:0045639|positive regulation of myeloid cell differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051897|positive regulation of protein kinase B signaling;GO:0071222|cellular response to lipopolysaccharide;GO:0071345|cellular response to cytokine stimulus;GO:1901215|negative regulation of neuron death;GO:2000251|positive regulation of actin cytoskeleton reorganization;","GO:0005615|extracellular space;","GO:0005125|cytokine activity;GO:0005130|granulocyte colony-stimulating factor receptor binding;GO:0008083|growth factor activity;GO:0019899|enzyme binding;","K05423","CSF3, GCSF; granulocyte colony-stimulating factor"]
["ENSRNOG00000019043",3,0.192991315,82,5.294072492,0.036454226,-4.777770123,{"v":1.79186e-20,"d":"1.79E-20"},{"v":2.9501e-20,"d":"2.95E-20"},"down","yes","Pdcd1","protein_coding","chr9:94418791-94431937:-","gi|157817590|ref|NP_001100397.1|",1469,0,"programmed cell death protein 1 precursor [Rattus norvegicus]","gi|672066226|ref|XM_008767395.1|",1927,0,"PREDICTED: Rattus norvegicus programmed cell death 1 (Pdcd1), transcript variant X1, mRNA","Q02242",485,{"v":1E-166,"d":"1.00E-166"},"Programmed cell death protein 1",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000014424",30,1.929913146,148,9.555155229,0.201976116,-2.307743389,{"v":2.63043e-20,"d":"2.63E-20"},{"v":4.31205e-20,"d":"4.31E-20"},"down","yes","RGD1563354","protein_coding","chr3:146850557-146884871:-","gi|564302770|ref|XP_006224793.1|",5900,0,"PREDICTED: uncharacterized protein KIAA1755 homolog isoform X2 [Rattus norvegicus]","gi|672017663|ref|XM_006224731.2|",3718,0,"PREDICTED: Rattus norvegicus similar to hypothetical protein D630003M21 (RGD1563354), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam13716","CRAL_TRIO_2","Divergent CRAL/TRIO domain. This family includes divergent members of the CRAL-TRIO domain family. This family includes ECM25 that contains a divergent CRAL-TRIO domain identified by Gallego and colleagues.",".",".",".",".","."]
["ENSRNOG00000013194",231,14.86033122,472,30.47319776,0.487652505,-1.036074627,{"v":2.76423e-20,"d":"2.76E-20"},{"v":4.5249e-20,"d":"4.52E-20"},"down","yes","Rps6ka2","protein_coding","chr1:52631736-52906739:+","gi|281306814|ref|NP_476469.1|",3661,0,"ribosomal protein S6 kinase alpha-2 [Rattus norvegicus]","gi|281306813|ref|NM_057128.1|",5073,0,"Rattus norvegicus ribosomal protein S6 kinase polypeptide 2 (Rps6ka2), mRNA","Q9WUT3",1410,0,"Ribosomal protein S6 kinase alpha-2",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0001556|oocyte maturation;GO:0002035|brain renin-angiotensin system;GO:0006468|protein phosphorylation;GO:0007507|heart development;GO:0008285|negative regulation of cell proliferation;GO:0010628|positive regulation of gene expression;GO:0010659|cardiac muscle cell apoptotic process;GO:0018105|peptidyl-serine phosphorylation;GO:0035556|intracellular signal transduction;GO:0043065|positive regulation of apoptotic process;GO:0045786|negative regulation of cell cycle;GO:0045835|negative regulation of meiotic nuclear division;GO:0060047|heart contraction;GO:0070613|regulation of protein processing;GO:0071322|cellular response to carbohydrate stimulus;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005819|spindle;GO:0005840|ribosome;GO:0072687|meiotic spindle;","GO:0000287|magnesium ion binding;GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0004711|ribosomal protein S6 kinase activity;GO:0004712|protein serine/threonine/tyrosine kinase activity;GO:0005524|ATP binding;","K04373","RPS6KA; ribosomal protein S6 kinase alpha-1/2/3/6 [EC:2.7.11.1]"]
["ENSRNOG00000007261",152,9.778226604,356,22.98402204,0.425435835,-1.232986537,{"v":3.05153e-20,"d":"3.05E-20"},{"v":4.9852e-20,"d":"4.99E-20"},"down","yes","Gli2","protein_coding","chr13:29946809-30163574:-","gi|672073723|ref|XP_008767677.1|",7125,0,"PREDICTED: zinc finger protein GLI2 isoform X1 [Rattus norvegicus]","gi|672073722|ref|XM_008769455.1|",6249,0,"PREDICTED: Rattus norvegicus GLI family zinc finger 2 (Gli2), transcript variant X1, mRNA","Q0VGT2",2536,0,"Zinc finger protein GLI2",".",".",".",".","pfam09770","PAT1","Topoisomerase II-associated protein PAT1. Members of this family are necessary for accurate chromosome transmission during cell division.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001501|skeletal system development;GO:0001649|osteoblast differentiation;GO:0001701|in utero embryonic development;GO:0001822|kidney development;GO:0002009|morphogenesis of an epithelium;GO:0002062|chondrocyte differentiation;GO:0002076|osteoblast development;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007224|smoothened signaling pathway;GO:0007389|pattern specification process;GO:0007411|axon guidance;GO:0007418|ventral midline development;GO:0007442|hindgut morphogenesis;GO:0007507|heart development;GO:0008284|positive regulation of cell proliferation;GO:0009612|response to mechanical stimulus;GO:0009913|epidermal cell differentiation;GO:0009952|anterior/posterior pattern specification;GO:0009953|dorsal/ventral pattern formation;GO:0009954|proximal/distal pattern formation;GO:0021508|floor plate formation;GO:0021513|spinal cord dorsal/ventral patterning;GO:0021517|ventral spinal cord development;GO:0021522|spinal cord motor neuron differentiation;GO:0021696|cerebellar cortex morphogenesis;GO:0021775|smoothened signaling pathway involved in ventral spinal cord interneuron specification;GO:0021776|smoothened signaling pathway involved in spinal cord motor neuron cell fate specification;GO:0021904|dorsal/ventral neural tube patterning;GO:0021915|neural tube development;GO:0021938|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation;GO:0021965|spinal cord ventral commissure morphogenesis;GO:0021983|pituitary gland development;GO:0030154|cell differentiation;GO:0030324|lung development;GO:0030850|prostate gland development;GO:0030879|mammary gland development;GO:0030902|hindbrain development;GO:0031069|hair follicle morphogenesis;GO:0032331|negative regulation of chondrocyte differentiation;GO:0035295|tube development;GO:0042475|odontogenesis of dentin-containing tooth;GO:0042733|embryonic digit morphogenesis;GO:0043066|negative regulation of apoptotic process;GO:0045666|positive regulation of neuron differentiation;GO:0045740|positive regulation of DNA replication;GO:0045879|negative regulation of smoothened signaling pathway;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048566|embryonic digestive tract development;GO:0048589|developmental growth;GO:0048646|anatomical structure formation involved in morphogenesis;GO:0048666|neuron development;GO:0048754|branching morphogenesis of an epithelial tube;GO:0048856|anatomical structure development;GO:0060032|notochord regression;GO:0060322|head development;GO:0060513|prostatic bud formation;GO:0060603|mammary gland duct morphogenesis;GO:0060831|smoothened signaling pathway involved in dorsal/ventral neural tube patterning;GO:0071407|cellular response to organic cyclic compound;GO:0090103|cochlea morphogenesis;GO:0098586|cellular response to virus;GO:1901620|regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005929|cilium;GO:0005930|axoneme;GO:0016020|membrane;GO:0016607|nuclear speck;GO:0031514|motile cilium;GO:0097542|ciliary tip;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003682|chromatin binding;GO:0003700|DNA-binding transcription factor activity;GO:0008270|zinc ion binding;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;GO:1990841|promoter-specific chromatin binding;","K16798","GLI2; zinc finger protein GLI2"]
["ENSRNOG00000009730",40,2.573217527,168,10.84639242,0.237241788,-2.075569947,{"v":3.24068e-20,"d":"3.24E-20"},{"v":5.29117e-20,"d":"5.29E-20"},"down","yes","Cyp7b1","protein_coding","chr2:100502791-100669698:-","gi|149048513|gb|EDM01054.1|",2391,0,"cytochrome P450, family 7, subfamily b, polypeptide 1 [Rattus norvegicus]","gi|158186666|ref|NM_019138.1|",2614,0,"Rattus norvegicus cytochrome P450, family 7, subfamily b, polypeptide 1 (Cyp7b1), mRNA","Q63688",786,0,"25-hydroxycholesterol 7-alpha-hydroxylase (Fragment)","YHR007c",82.4,{"v":2e-15,"d":"2.00E-15"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0006699|bile acid biosynthetic process;GO:0007613|memory;GO:0007623|circadian rhythm;GO:0008203|cholesterol metabolic process;GO:0009410|response to xenobiotic stimulus;GO:0033147|negative regulation of intracellular estrogen receptor signaling pathway;GO:0035754|B cell chemotaxis;GO:0042632|cholesterol homeostasis;GO:0050679|positive regulation of epithelial cell proliferation;GO:0051591|response to cAMP;GO:0060740|prostate gland epithelium morphogenesis;","GO:0005575|cellular_component;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0004497|monooxygenase activity;GO:0005506|iron ion binding;GO:0008395|steroid hydroxylase activity;GO:0008396|oxysterol 7-alpha-hydroxylase activity;GO:0016705|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0020037|heme binding;GO:0033783|25-hydroxycholesterol 7alpha-hydroxylase activity;GO:0047092|27-hydroxycholesterol 7-alpha-monooxygenase activity;","K07430","CYP7B; 25/26-hydroxycholesterol 7alpha-hydroxylase [EC:1.14.14.29]"]
["ENSRNOG00000051056",97,6.240052504,269,17.36714025,0.359302246,-1.47673014,{"v":3.60969e-20,"d":"3.61E-20"},{"v":5.88358e-20,"d":"5.88E-20"},"down","yes","AABR07063279.1","protein_coding","chr6:25077349-25080675:+","gi|507958750|ref|XP_004686404.1|",292,{"v":8e-27,"d":"8.00E-27"},"PREDICTED: fibronectin type III domain-containing protein 4 [Condylura cristata]","gi|672055606|ref|XR_592911.1|",1005,0,"PREDICTED: Rattus norvegicus uncharacterized LOC100910821 (LOC100910821), ncRNA","A6QPL2",115,{"v":8e-28,"d":"8.00E-28"},"Fibronectin type III domain-containing protein 4",".",".",".",".","pfam04602","Arabinose_trans","Mycobacterial cell wall arabinan synthesis protein. Arabinosyltransferase is involved in arabinogalactan (AG) biosynthesis pathway in mycobacteria. AG is a component of the macromolecular assembly of the mycolyl-AG-peptidoglycan complex of the cell wall. This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug Ethambutol.",".",".",".",".","."]
["ENSRNOG00000070434",17,1.093617449,118,7.618299439,0.143551387,-2.800360827,{"v":4.09188E-20,"d":"4.09E-20"},{"v":6.66192e-20,"d":"6.66E-20"},"down","yes","ENSRNOG00000070434","protein_coding","chr2:193412971-193420030:-","gi|564300827|ref|XP_006224300.1|",584,{"v":3e-70,"d":"3.00E-70"},"PREDICTED: transmembrane protein C1orf162 homolog [Rattus norvegicus]","gi|672016201|ref|XM_006224238.2|",1031,0,"PREDICTED: Rattus norvegicus hypothetical LOC100363228 (LOC100363228), mRNA","Q3U7U4",137,{"v":5e-37,"d":"5.00E-37"},"Transmembrane protein C1orf162 homolog",".",".",".",".","pfam00852","Glyco_transf_10","Glycosyltransferase family 10 (fucosyltransferase). This family of Fucosyltransferases are the enzymes transferring fucose from GDP-Fucose to GlcNAc in an alpha1,3 linkage. This family is know as glycosyltransferase family 10.",".",".",".",".","."]
["ENSRNOG00000029889",0,0.032165219,83,5.358634351,0.006002503,-7.380220051,{"v":4.26918E-20,"d":"4.27E-20"},{"v":6.94463e-20,"d":"6.94E-20"},"down","yes","Clca4","protein_coding","chr2:233883851-233903089:-","gi|41386751|ref|NP_958822.1|",4686,0,"calcium-activated chloride channel regulator 4 precursor [Rattus norvegicus]","gi|41386750|ref|NM_201419.1|",2876,0,"Rattus norvegicus chloride channel accessory 4 (Clca4), mRNA","Q6Q473",1505,0,"Calcium-activated chloride channel regulator 4A","MA0247",52,7e-06,"COG2304","pfam08434","CLCA_N","Calcium-activated chloride channel. The CLCA family of calcium-activated chloride channels has been identified in many epithelial and endothelial cell types as well as in smooth muscle cells and has four or five putative transmembrane regions. Additionally to their role as chloride channels some CLCA proteins function as adhesion molecules and may also have roles as tumor suppressors. The domain described here is found at the N-terminus of CLCAs.","GO:0006508|proteolysis;GO:0006821|chloride transport;","GO:0005887|integral component of plasma membrane;","GO:0005229|intracellular calcium activated chloride channel activity;GO:0008237|metallopeptidase activity;GO:0046872|metal ion binding;","K05030","CLCA3_4; calcium-activated chloride channel regulator 3/4"]
["ENSRNOG00000032618",43,2.766208842,173,11.16920172,0.24766397,-2.013544092,{"v":4.93599e-20,"d":"4.94E-20"},{"v":8.01563e-20,"d":"8.02E-20"},"down","yes","Mst1r","protein_coding","chr8:108597299-108612455:+","gi|158749582|ref|NP_001100325.2|",6806,0,"macrophage-stimulating protein receptor precursor [Rattus norvegicus]","gi|158749581|ref|NM_001106855.2|",2961,0,"Rattus norvegicus macrophage stimulating 1 receptor (c-met-related tyrosine kinase) (Mst1r), mRNA","Q62190",2355,0,"Macrophage-stimulating protein receptor",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0006909|phagocytosis;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007275|multicellular organism development;GO:0007399|nervous system development;GO:0009615|response to virus;GO:0016477|cell migration;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0033674|positive regulation of kinase activity;GO:0043406|positive regulation of MAP kinase activity;GO:0051897|positive regulation of protein kinase B signaling;","GO:0001725|stress fiber;GO:0005773|vacuole;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009925|basal plasma membrane;GO:0043235|receptor complex;","GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0005524|ATP binding;GO:0019899|enzyme binding;","K05100","MST1R, RON, CD136; macrophage-stimulating 1 receptor [EC:2.7.10.1]"]
["ENSRNOG00000021087",35,2.251565336,157,10.13621197,0.222130846,-2.170518351,{"v":5.21845e-20,"d":"5.22E-20"},{"v":8.46469e-20,"d":"8.46E-20"},"down","yes","Lgi4","protein_coding","chr1:86295074-86304874:+","gi|41054852|ref|NP_955793.1|",2732,0,"leucine-rich repeat LGI family member 4 precursor [Rattus norvegicus]","gi|41054851|ref|NM_199499.1|",2533,0,"Rattus norvegicus leucine-rich repeat LGI family, member 4 (Lgi4), mRNA","Q8K1S1",1030,0,"Leucine-rich repeat LGI family member 4",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.","GO:0008344|adult locomotory behavior;GO:0014009|glial cell proliferation;GO:0014044|Schwann cell development;GO:0021782|glial cell development;GO:0022011|myelination in peripheral nervous system;GO:0031641|regulation of myelination;GO:0042063|gliogenesis;GO:0042551|neuron maturation;GO:0042552|myelination;","GO:0005615|extracellular space;",".","K25430","LGI4; leucine-rich repeat LGI family member 4"]
["ENSRNOG00000046361",12,0.771965258,105,6.778995264,0.113876058,-3.134463636,{"v":5.53338e-20,"d":"5.53E-20"},{"v":8.97298E-20,"d":"8.97E-20"},"down","yes","Hoxa7","protein_coding","chr4:81314625-81317659:-","gi|158711670|ref|NP_001102703.2|",1163,{"v":9E-153,"d":"9.00E-153"},"homeobox protein Hox-A7 [Rattus norvegicus]","gi|49457875|gb|AC122669.6|",1537,0,"Rattus norvegicus 4 BAC CH230-172C22 (Children's Hospital Oakland Research Institute) complete sequence","P02830",444,{"v":3e-151,"d":"3.00E-151"},"Homeobox protein Hox-A7",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001525|angiogenesis;GO:0001953|negative regulation of cell-matrix adhesion;GO:0002686|negative regulation of leukocyte migration;GO:0006357|regulation of transcription by RNA polymerase II;GO:0009952|anterior/posterior pattern specification;GO:0045617|negative regulation of keratinocyte differentiation;GO:0045656|negative regulation of monocyte differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048704|embryonic skeletal system morphogenesis;GO:0048863|stem cell differentiation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0031965|nuclear membrane;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09307","HOX_7; homeobox protein HoxA/B7"]
["ENSRNOG00000013554",25,1.608260955,135,8.715851053,0.18452139,-2.438140027,{"v":8.36604e-20,"d":"8.37E-20"},{"v":1.34899e-19,"d":"1.35E-19"},"down","yes","Treml2","protein_coding","chr9:12694697-12705324:-","gi|109485725|ref|XP_001059150.1|",1670,0,"PREDICTED: trem-like transcript 2 protein isoform X2 [Rattus norvegicus]","gi|672023707|ref|XM_002727159.4|",2597,0,"PREDICTED: Rattus norvegicus triggering receptor expressed on myeloid cells-like 2 (Treml2), transcript variant X3, mRNA","Q2LA85",483,{"v":2e-157,"d":"2.00E-157"},"Trem-like transcript 2 protein",".",".",".",".","pfam07502","MANEC","MANEC domain. This region of similarity, comprising 8 conserved cysteines, is found in the N-terminal region of several membrane-associated and extracellular proteins. Although formerly called MANSC (for motif at N terminus with seven cysteines) it has now been renamed by MANEC (motif at N terminus with eight cysteines) by Richard Mitter and Stephen Fitzgerald after the discovery of an eighth conserved cysteine. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors.","GO:0042110|T cell activation;","GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0038023|signaling receptor activity;","K14364","TLT2; trem-like transcript 2 protein"]
["ENSRNOG00000014683",1,0.064330438,77,4.971263193,0.012940461,-6.27196716,{"v":8.53145e-20,"d":"8.53E-20"},{"v":1.37527E-19,"d":"1.38E-19"},"down","yes","Il1rl2","protein_coding","chr9:42591934-42636667:+","gi|149046283|gb|EDL99176.1|",2955,0,"interleukin 1 receptor-like 2, isoform CRA_a [Rattus norvegicus]","gi|19424265|ref|NM_133575.1|",2027,0,"Rattus norvegicus interleukin 1 receptor-like 2 (Il1rl2), mRNA","Q62929",1135,0,"Interleukin-1 receptor-like 2",".",".",".",".","pfam01582","TIR","TIR domain. The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.","GO:0019221|cytokine-mediated signaling pathway;GO:0032755|positive regulation of interleukin-6 production;GO:0045582|positive regulation of T cell differentiation;GO:0050727|regulation of inflammatory response;","GO:0016021|integral component of membrane;","GO:0003953|NAD+ nucleosidase activity;GO:0004908|interleukin-1 receptor activity;GO:0050135|NAD(P)+ nucleosidase activity;GO:0061809|NAD+ nucleotidase, cyclic ADP-ribose generating;","K05172","IL1RL2, IL1RRP2; interleukin 1 receptor-like 2"]
["ENSRNOG00000006062",199,12.8017572,422,27.24510477,0.469873664,-1.089655188,{"v":9.74978e-20,"d":"9.75E-20"},{"v":1.56768E-19,"d":"1.57E-19"},"down","yes","Hs1bp3","protein_coding","chr6:31192568-31222835:+","gi|293347971|ref|XP_001071788.2|",1835,0,"PREDICTED: HCLS1-binding protein 3 [Rattus norvegicus]","gi|672020539|ref|XM_001071788.5|",3011,0,"PREDICTED: Rattus norvegicus HCLS1 binding protein 3 (Hs1bp3), mRNA","Q3TC93",630,0,"HCLS1-binding protein 3",".",".",".",".","pfam00787","PX","PX domain. PX domains bind to phosphoinositides.","GO:0042981|regulation of apoptotic process;","GO:0005739|mitochondrion;GO:0005783|endoplasmic reticulum;","GO:0035091|phosphatidylinositol binding;","K24094","HS1BP3; HCLS1-binding protein 3"]
["ENSRNOG00000002525",24,1.543930516,132,8.522165474,0.181166456,-2.464612238,{"v":1.27288E-19,"d":"1.27E-19"},{"v":2.03921e-19,"d":"2.04E-19"},"down","yes","Ptgs2","protein_coding","chr13:62163932-62172188:+","gi|148747270|ref|NP_058928.3|",3077,0,"prostaglandin G/H synthase 2 precursor [Rattus norvegicus]","gi|7110562|gb|AF233596.1|AF233596",4200,0,"Rattus norvegicus cyclooxygenase-2 mRNA, complete cds","P35355",1188,0,"Prostaglandin G/H synthase 2",".",".",".",".","pfam03098","An_peroxidase","Animal haem peroxidase.","GO:0001516|prostaglandin biosynthetic process;GO:0001525|angiogenesis;GO:0006954|inflammatory response;GO:0006979|response to oxidative stress;GO:0007566|embryo implantation;GO:0007568|aging;GO:0007612|learning;GO:0007613|memory;GO:0008217|regulation of blood pressure;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0009314|response to radiation;GO:0009410|response to xenobiotic stimulus;GO:0009750|response to fructose;GO:0010033|response to organic substance;GO:0010042|response to manganese ion;GO:0010226|response to lithium ion;GO:0010243|response to organonitrogen compound;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0010942|positive regulation of cell death;GO:0014070|response to organic cyclic compound;GO:0019233|sensory perception of pain;GO:0019371|cyclooxygenase pathway;GO:0030282|bone mineralization;GO:0030728|ovulation;GO:0031394|positive regulation of prostaglandin biosynthetic process;GO:0031622|positive regulation of fever generation;GO:0031915|positive regulation of synaptic plasticity;GO:0032227|negative regulation of synaptic transmission, dopaminergic;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0033280|response to vitamin D;GO:0034097|response to cytokine;GO:0034605|cellular response to heat;GO:0034612|response to tumor necrosis factor;GO:0034644|cellular response to UV;GO:0035633|maintenance of permeability of blood-brain barrier;GO:0042127|regulation of cell proliferation;GO:0042307|positive regulation of protein import into nucleus;GO:0042633|hair cycle;GO:0043065|positive regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0045786|negative regulation of cell cycle;GO:0045907|positive regulation of vasoconstriction;GO:0045986|negative regulation of smooth muscle contraction;GO:0045987|positive regulation of smooth muscle contraction;GO:0046697|decidualization;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0050873|brown fat cell differentiation;GO:0051384|response to glucocorticoid;GO:0051926|negative regulation of calcium ion transport;GO:0051968|positive regulation of synaptic transmission, glutamatergic;GO:0070542|response to fatty acid;GO:0071260|cellular response to mechanical stimulus;GO:0071284|cellular response to lead ion;GO:0071318|cellular response to ATP;GO:0071456|cellular response to hypoxia;GO:0071471|cellular response to non-ionic osmotic stress;GO:0071498|cellular response to fluid shear stress;GO:0071636|positive regulation of transforming growth factor beta production;GO:0090050|positive regulation of cell migration involved in sprouting angiogenesis;GO:0090271|positive regulation of fibroblast growth factor production;GO:0090336|positive regulation of brown fat cell differentiation;GO:0090362|positive regulation of platelet-derived growth factor production;GO:0098869|cellular oxidant detoxification;GO:0150077|regulation of neuroinflammatory response;GO:1902219|negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress;GO:1990776|response to angiotensin;","GO:0005637|nuclear inner membrane;GO:0005640|nuclear outer membrane;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005901|caveola;GO:0032991|protein-containing complex;GO:0043005|neuron projection;","GO:0004601|peroxidase activity;GO:0004666|prostaglandin-endoperoxide synthase activity;GO:0005515|protein binding;GO:0016702|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;GO:0019899|enzyme binding;GO:0020037|heme binding;GO:0042803|protein homodimerization activity;GO:0046872|metal ion binding;","K11987","PTGS2, COX2; prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]"]
["ENSRNOG00000025142",114,7.333669953,293,18.91662488,0.38768385,-1.36704746,{"v":1.32667E-19,"d":"1.33E-19"},{"v":2.12301e-19,"d":"2.12E-19"},"down","yes","Mex3b","protein_coding","chr1:136855130-136859354:+","gi|50511245|dbj|BAD32608.1|",2172,0,"mKIAA2009 protein [Mus musculus]","gi|300798391|ref|NM_001191626.1|",3390,0,"Rattus norvegicus mex-3 RNA binding family member B (Mex3b), mRNA","Q69Z36",697,0,"RNA-binding protein MEX3B",".",".",".",".","pfam13920","zf-C3HC4_3","Zinc finger, C3HC4 type (RING finger).","GO:0022409|positive regulation of cell-cell adhesion;GO:0043547|positive regulation of GTPase activity;GO:0050766|positive regulation of phagocytosis;GO:0072697|protein localization to cell cortex;","GO:0000932|P-body;GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0003723|RNA binding;GO:0032794|GTPase activating protein binding;GO:0046872|metal ion binding;","K15686","MEX3, RKHD; RNA-binding protein MEX3 [EC:2.3.2.27]"]
["ENSRNOG00000021244",199,12.8017572,421,27.18054291,0.470989753,-1.086232422,{"v":1.33141E-19,"d":"1.33E-19"},{"v":2.12941E-19,"d":"2.13E-19"},"down","yes","Hspa12b","protein_coding","chr3:118346354-118364737:+","gi|564343033|ref|XP_006235089.1|",3485,0,"PREDICTED: heat shock 70 kDa protein 12B isoform X1 [Rattus norvegicus]","gi|157821188|ref|NM_001107778.1|",3333,0,"Rattus norvegicus heat shock protein 12B (Hspa12b), mRNA","Q9CZJ2",1324,0,"Heat shock 70 kDa protein 12B",".",".",".",".","pfam10712","NAD-GH","NAD-specific glutamate dehydrogenase. The members of this are annotated as being NAD-specific glutamate dehydrogenase encoded in antisense gene pair with DnaK-J.",".",".",".",".","."]
["ENSRNOG00000016069",10,0.643304382,98,6.327062246,0.101675052,-3.297962369,{"v":1.50957E-19,"d":"1.51E-19"},{"v":2.41098e-19,"d":"2.41E-19"},"down","yes","Cd3e","protein_coding","chr8:45303852-45315022:-","gi|672061635|ref|XP_008764383.1|",818,{"v":2E-99,"d":"2.00E-99"},"PREDICTED: T-cell surface glycoprotein CD3 epsilon chain isoform X1 [Rattus norvegicus]","gi|672061634|ref|XM_008766161.1|",1103,0,"PREDICTED: Rattus norvegicus CD3 molecule, epsilon (Cd3e), transcript variant X1, mRNA","P22646",247,{"v":4e-74,"d":"4.00E-74"},"T-cell surface glycoprotein CD3 epsilon chain",".",".",".",".","pfam02189","ITAM","Immunoreceptor tyrosine-based activation motif.","GO:0001954|positive regulation of cell-matrix adhesion;GO:0002250|adaptive immune response;GO:0002669|positive regulation of T cell anergy;GO:0007166|cell surface receptor signaling pathway;GO:0007584|response to nutrient;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0016358|dendrite development;GO:0021549|cerebellum development;GO:0031295|T cell costimulation;GO:0032729|positive regulation of interferon-gamma production;GO:0032743|positive regulation of interleukin-2 production;GO:0032753|positive regulation of interleukin-4 production;GO:0033077|T cell differentiation in thymus;GO:0033634|positive regulation of cell-cell adhesion mediated by integrin;GO:0042102|positive regulation of T cell proliferation;GO:0045059|positive thymic T cell selection;GO:0045060|negative thymic T cell selection;GO:0045879|negative regulation of smoothened signaling pathway;GO:0046641|positive regulation of alpha-beta T cell proliferation;GO:0046649|lymphocyte activation;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050850|positive regulation of calcium-mediated signaling;GO:0050852|T cell receptor signaling pathway;GO:0050870|positive regulation of T cell activation;GO:0097190|apoptotic signaling pathway;","GO:0001772|immunological synapse;GO:0005575|cellular_component;GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0042101|T cell receptor complex;GO:0042105|alpha-beta T cell receptor complex;GO:0043197|dendritic spine;GO:0044297|cell body;","GO:0003674|molecular_function;GO:0004888|transmembrane signaling receptor activity;GO:0017124|SH3 domain binding;GO:0042802|identical protein binding;GO:0046982|protein heterodimerization activity;","K06451","CD3E; T-cell surface glycoprotein CD3 epsilon chain"]
["ENSRNOG00000032429",15,0.964956573,110,7.101804562,0.135874842,-2.879649737,{"v":2.35305e-19,"d":"2.35E-19"},{"v":3.73305e-19,"d":"3.73E-19"},"down","yes","Tmprss9","protein_coding","chr7:8810320-8831177:-","gi|564358159|ref|XP_006240993.1|",5252,0,"PREDICTED: transmembrane protease serine 9 isoform X1 [Rattus norvegicus]","gi|564358158|ref|XM_006240931.1|",3455,0,"PREDICTED: Rattus norvegicus transmembrane protease, serine 9 (Tmprss9), transcript variant X1, mRNA","P69526",1943,0,"Transmembrane protease serine 9","VC1649",117,{"v":2e-26,"d":"2.00E-26"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;GO:0031639|plasminogen activation;","GO:0005887|integral component of plasma membrane;GO:0016020|membrane;","GO:0004252|serine-type endopeptidase activity;GO:0008236|serine-type peptidase activity;","K09640","TMPRSS9; transmembrane protease serine 9 [EC:3.4.21.-]"]
["ENSRNOG00000064828",48,3.087861033,179,11.55657288,0.26719522,-1.904033896,{"v":2.59111e-19,"d":"2.59E-19"},{"v":4.10389e-19,"d":"4.10E-19"},"down","yes","ENSRNOG00000064828","lncRNA","chr2:191236860-191242490:-","gi|149030443|gb|EDL85480.1|",283,{"v":2e-26,"d":"2.00E-26"},"rCG51968 [Rattus norvegicus]","gi|672016171|ref|XR_599902.1|",663,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102547265 (LOC102547265), transcript variant X2, ncRNA",".",".",".",".",".",".",".",".","pfam01673","Herpes_env","Herpesvirus putative major envelope glycoprotein. This family consists of probable major envelope glycoproteins from members of the herpesviridae including herpes simplex virus, human cytomegalovirus and varicella-zoster virus. Members of the herpesviridae have a dsDNA genome and do not have a RNA stage during there replication.",".",".",".",".","."]
["ENSRNOG00000066006",5,0.321652191,83,5.358634351,0.060025031,-4.058291956,{"v":2.76417e-19,"d":"2.76E-19"},{"v":4.37435e-19,"d":"4.37E-19"},"down","yes","ENSRNOG00000066006","protein_coding","chr7:15243866-15419034:+","gi|45219799|gb|AAH67002.1|",457,{"v":3e-48,"d":"3.00E-48"},"4632419I22Rik protein [Mus musculus]","gi|315434303|gb|AC243170.5|",836,0,"Rattus norvegicus Y Chr BAC RNAEX-212I22 (Amplicon Express Rat SHR-Akr BAC library) complete sequence","P26804",157,{"v":7E-39,"d":"7.00E-39"},"Envelope glycoprotein",".",".",".",".","pfam00429","TLV_coat","ENV polyprotein (coat polyprotein).",".",".",".",".","."]
["ENSRNOG00000016156",38,2.444556651,159,10.26533569,0.23813704,-2.070136061,{"v":3.70176e-19,"d":"3.70E-19"},{"v":5.83708e-19,"d":"5.84E-19"},"down","yes","Nptxr","protein_coding","chr7:111336664-111354802:-","gi|149065907|gb|EDM15780.1|",2140,0,"neuronal pentraxin receptor [Rattus norvegicus]","gi|160707897|ref|NM_030841.3|",4840,0,"Rattus norvegicus neuronal pentraxin receptor (Nptxr), mRNA","O35764",824,0,"Neuronal pentraxin receptor",".",".",".",".","pfam00354","Pentaxin","Pentaxin family. Pentaxins are also known as pentraxins.","GO:0031175|neuron projection development;GO:0042542|response to hydrogen peroxide;GO:0098962|regulation of postsynaptic neurotransmitter receptor activity;GO:0099150|regulation of postsynaptic specialization assembly;GO:0099645|neurotransmitter receptor localization to postsynaptic specialization membrane;","GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0098978|glutamatergic synapse;","GO:0008029|pentraxin receptor activity;GO:0019903|protein phosphatase binding;GO:0044877|protein-containing complex binding;GO:0046872|metal ion binding;","K25710","NPTXR; neuronal pentraxin receptor"]
["ENSRNOG00000019614",36,2.315895775,155,10.00708825,0.231425537,-2.111380023,{"v":3.74981e-19,"d":"3.75E-19"},{"v":5.91121e-19,"d":"5.91E-19"},"down","yes","Ptpn22","protein_coding","chr2:191366808-191414779:+","gi|157824150|ref|NP_001099930.1|",4102,0,"tyrosine-protein phosphatase non-receptor type 22 [Rattus norvegicus]","gi|157824149|ref|NM_001106460.1|",2747,0,"Rattus norvegicus protein tyrosine phosphatase, non-receptor type 22 (Ptpn22), mRNA","P29352",1358,0,"Tyrosine-protein phosphatase non-receptor type 22","SPAC19D5.01",120,{"v":4e-27,"d":"4.00E-27"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0002230|positive regulation of defense response to virus by host;GO:0002685|regulation of leukocyte migration;GO:0006470|protein dephosphorylation;GO:0010507|negative regulation of autophagy;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0030217|T cell differentiation;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0032481|positive regulation of type I interferon production;GO:0032496|response to lipopolysaccharide;GO:0032715|negative regulation of interleukin-6 production;GO:0032717|negative regulation of interleukin-8 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032727|positive regulation of interferon-alpha production;GO:0032728|positive regulation of interferon-beta production;GO:0032729|positive regulation of interferon-gamma production;GO:0032817|regulation of natural killer cell proliferation;GO:0034141|positive regulation of toll-like receptor 3 signaling pathway;GO:0034145|positive regulation of toll-like receptor 4 signaling pathway;GO:0034157|positive regulation of toll-like receptor 7 signaling pathway;GO:0034165|positive regulation of toll-like receptor 9 signaling pathway;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0035644|phosphoanandamide dephosphorylation;GO:0042307|positive regulation of protein import into nucleus;GO:0043508|negative regulation of JUN kinase activity;GO:0050730|regulation of peptidyl-tyrosine phosphorylation;GO:0050852|T cell receptor signaling pathway;GO:0050860|negative regulation of T cell receptor signaling pathway;GO:0050868|negative regulation of T cell activation;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070433|negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0071225|cellular response to muramyl dipeptide;GO:0071663|positive regulation of granzyme B production;GO:1901222|regulation of NIK/NF-kappaB signaling;GO:1902523|positive regulation of protein K63-linked ubiquitination;GO:1903169|regulation of calcium ion transmembrane transport;GO:1903753|negative regulation of p38MAPK cascade;GO:2000566|positive regulation of CD8-positive, alpha-beta T cell proliferation;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0009898|cytoplasmic side of plasma membrane;GO:0048471|perinuclear region of cytoplasm;","GO:0004725|protein tyrosine phosphatase activity;GO:0004726|non-membrane spanning protein tyrosine phosphatase activity;GO:0016791|phosphatase activity;GO:0017124|SH3 domain binding;GO:0019900|kinase binding;GO:0031625|ubiquitin protein ligase binding;GO:1990782|protein tyrosine kinase binding;","K18024","PTPN12_18_22; tyrosine-protein phosphatase non-receptor type 12/18/22 [EC:3.1.3.48]"]
["ENSRNOG00000025476",155,9.971217919,353,22.79033646,0.437519557,-1.192580587,{"v":3.8983e-19,"d":"3.90E-19"},{"v":6.14021e-19,"d":"6.14E-19"},"down","yes","Tmem252","protein_coding","chr1:222316795-222321943:+","gi|56090345|ref|NP_001007739.1|",863,{"v":1E-107,"d":"1.00E-107"},"transmembrane protein 252 [Rattus norvegicus]","gi|56090344|ref|NM_001007738.1|",2049,0,"Rattus norvegicus transmembrane protein 252 (Tmem252), mRNA","Q6AXS2",337,{"v":3e-109,"d":"3.00E-109"},"Transmembrane protein 252",".",".",".",".","pfam06797","DUF1229","Protein of unknown function (DUF1229). This family consists of several hypothetical proteins of around 415 residues in length which seem to be specific to the bacterium Leptospira interrogans.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000046744",10,0.643304382,96,6.197938527,0.103793282,-3.268215025,{"v":4.81679e-19,"d":"4.82E-19"},{"v":7.56814e-19,"d":"7.57E-19"},"down","yes","Ankrd29","protein_coding","chr18:3436303-3494296:-","gi|298566258|ref|NP_001177301.1|",1564,0,"ankyrin repeat domain-containing protein 29 [Rattus norvegicus]","gi|298566257|ref|NM_001190372.1|",3067,0,"Rattus norvegicus ankyrin repeat domain 29 (Ankrd29), mRNA",".",".",".",".","all2748",140,{"v":4e-34,"d":"4.00E-34"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).",".",".",".",".","."]
["ENSRNOG00000000855",29,1.865582707,140,9.038660352,0.206400355,-2.276482641,{"v":5.26643e-19,"d":"5.27E-19"},{"v":8.26551e-19,"d":"8.27E-19"},"down","yes","Lst1","protein_coding","chr20:3634749-3637997:+","gi|260166685|ref|NP_072156.2|",520,{"v":4e-65,"d":"4.00E-65"},"leukocyte-specific transcript 1 protein [Rattus norvegicus]","gi|260166684|ref|NM_022634.2|",438,0,"Rattus norvegicus leukocyte specific transcript 1 (Lst1), mRNA","O08843",79.7,{"v":3e-18,"d":"3.00E-18"},"Leukocyte-specific transcript 1 protein",".",".",".",".","pfam05083","LST1","LST-1 protein. B144/LST1 is a gene encoded in the human major histocompatibility complex that produces multiple forms of alternatively spliced mRNA and encodes peptides fewer than 100 amino acids in length. B144/LST1 is strongly expressed in dendritic cells. Transfection of B144/LST1 into a variety of cells induces morphologic changes including the production of long, thin filopodia.","GO:0000902|cell morphogenesis;GO:0006955|immune response;GO:0008150|biological_process;GO:0016358|dendrite development;GO:0050672|negative regulation of lymphocyte proliferation;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;",".","."]
["ENSRNOG00000028832",4,0.257321753,79,5.100386913,0.050451418,-4.308961368,{"v":5.36679e-19,"d":"5.37E-19"},{"v":8.4184e-19,"d":"8.42E-19"},"down","yes","Sorcs3","protein_coding","chr1:247099408-247734027:+","gi|300244496|ref|NP_001099837.2|",6176,0,"VPS10 domain-containing receptor SorCS3 precursor [Rattus norvegicus]","gi|393794766|ref|NM_001106367.3|",5537,0,"Rattus norvegicus sortilin-related VPS10 domain containing receptor 3 (Sorcs3), mRNA","Q8VI51",2336,0,"VPS10 domain-containing receptor SorCS3",".",".",".",".","pfam00801","PKD","PKD domain. This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.","GO:0007612|learning;GO:0007613|memory;GO:0008150|biological_process;GO:1900452|regulation of long-term synaptic depression;","GO:0005575|cellular_component;GO:0014069|postsynaptic density;GO:0016021|integral component of membrane;GO:0098978|glutamatergic synapse;GO:0099061|integral component of postsynaptic density membrane;","GO:0003674|molecular_function;",".","."]
["ENSRNOG00000047046",48,3.087861033,177,11.42744916,0.270214375,-1.887823669,{"v":6.48719e-19,"d":"6.49E-19"},{"v":1.01369e-18,"d":"1.01E-18"},"down","yes","Plin4","protein_coding","chr9:929176-938056:-","gi|564366978|ref|XP_006244434.1|",6512,0,"PREDICTED: perilipin-4 isoform X1 [Rattus norvegicus]","gi|672064137|ref|XM_006244372.2|",5578,0,"PREDICTED: Rattus norvegicus perilipin 4 (Plin4), transcript variant X1, mRNA","O88492",1558,0,"Perilipin-4",".",".",".",".","pfam03036","Perilipin","Perilipin family. The perilipin family includes lipid droplet-associated protein (perilipin) and adipose differentiation-related protein (adipophilin).",".","GO:0005811|lipid droplet;GO:0005829|cytosol;GO:0005886|plasma membrane;",".","K20254","PLIN4; perilipin-4"]
["ENSRNOG00000047699",48,3.087861033,177,11.42744916,0.270214375,-1.887823669,{"v":6.48719e-19,"d":"6.49E-19"},{"v":1.01369e-18,"d":"1.01E-18"},"down","yes","Snai2","protein_coding","chr11:86181909-86186200:-","gi|29789044|ref|NP_037167.1|",1348,{"v":1E-176,"d":"1.00E-176"},"zinc finger protein SNAI2 [Rattus norvegicus]","gi|625292689|ref|XM_007639910.1|",1285,0,"PREDICTED: Cricetulus griseus snail family zinc finger 2 (Snai2), mRNA","O08954",523,{"v":3e-178,"d":"3.00E-178"},"Zinc finger protein SNAI2",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001649|osteoblast differentiation;GO:0001837|epithelial to mesenchymal transition;GO:0003198|epithelial to mesenchymal transition involved in endocardial cushion formation;GO:0003273|cell migration involved in endocardial cushion formation;GO:0006355|regulation of transcription, DNA-templated;GO:0006929|substrate-dependent cell migration;GO:0006933|negative regulation of cell adhesion involved in substrate-bound cell migration;GO:0007219|Notch signaling pathway;GO:0007605|sensory perception of sound;GO:0009314|response to radiation;GO:0010839|negative regulation of keratinocyte proliferation;GO:0010957|negative regulation of vitamin D biosynthetic process;GO:0014032|neural crest cell development;GO:0016477|cell migration;GO:0030335|positive regulation of cell migration;GO:0032331|negative regulation of chondrocyte differentiation;GO:0032642|regulation of chemokine production;GO:0033629|negative regulation of cell adhesion mediated by integrin;GO:0035066|positive regulation of histone acetylation;GO:0035921|desmosome disassembly;GO:0043066|negative regulation of apoptotic process;GO:0043473|pigmentation;GO:0043518|negative regulation of DNA damage response, signal transduction by p53 class mediator;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0045600|positive regulation of fat cell differentiation;GO:0045667|regulation of osteoblast differentiation;GO:0050872|white fat cell differentiation;GO:0060021|roof of mouth development;GO:0060429|epithelium development;GO:0060536|cartilage morphogenesis;GO:0060693|regulation of branching involved in salivary gland morphogenesis;GO:0070563|negative regulation of vitamin D receptor signaling pathway;GO:0071364|cellular response to epidermal growth factor stimulus;GO:0071479|cellular response to ionizing radiation;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:1902230|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:2000647|negative regulation of stem cell proliferation;GO:2000810|regulation of bicellular tight junction assembly;GO:2000811|negative regulation of anoikis;GO:2001240|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;","GO:0000785|chromatin;GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003682|chromatin binding;GO:0043565|sequence-specific DNA binding;GO:0046872|metal ion binding;GO:0070888|E-box binding;GO:1990837|sequence-specific double-stranded DNA binding;","K05706","SNAI2, SLUG; snail 2"]
["ENSRNOG00000003278",124,7.976974335,304,19.62680534,0.406432641,-1.298911822,{"v":7.2566E-19,"d":"7.26E-19"},{"v":1.13071E-18,"d":"1.13E-18"},"down","yes","Map3k14","protein_coding","chr10:88165351-88215523:-","gi|157819457|ref|NP_001101771.1|",4283,0,"mitogen-activated protein kinase kinase kinase 14 [Rattus norvegicus]","gi|157819456|ref|NM_001108301.1|",4206,0,"Rattus norvegicus mitogen-activated protein kinase kinase kinase 14 (Map3k14), mRNA","Q9WUL6",1554,0,"Mitogen-activated protein kinase kinase kinase 14",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0000165|MAPK cascade;GO:0006468|protein phosphorylation;GO:0006955|immune response;GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0032147|activation of protein kinase activity;GO:0038061|NIK/NF-kappaB signaling;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0051607|defense response to virus;GO:0071260|cellular response to mechanical stimulus;","GO:0001650|fibrillar center;GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0043231|intracellular membrane-bounded organelle;","GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0004704|NF-kappaB-inducing kinase activity;GO:0004709|MAP kinase kinase kinase activity;GO:0005524|ATP binding;","K04466","MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25]"]
["ENSRNOG00000037718",7,0.450313067,87,5.61688179,0.080171363,-3.640769193,{"v":7.67864e-19,"d":"7.68E-19"},{"v":1.19366e-18,"d":"1.19E-18"},"down","yes","Cfap52","protein_coding","chr10:52613762-52654934:-","gi|187281569|ref|NP_001094438.2|",3255,0,"WD repeat-containing protein 16 [Rattus norvegicus]","gi|187281568|ref|NM_001100968.2|",2225,0,"Rattus norvegicus cilia and flagella associated protein 52 (Cfap52), mRNA","Q5F201",1241,0,"Cilia- and flagella-associated protein 52","all0283_3",113,{"v":3e-25,"d":"3.00E-25"},"COG2319","pfam00400","WD40","WD domain, G-beta repeat.","GO:0030317|flagellated sperm motility;GO:0060271|cilium assembly;GO:0061966|establishment of left/right asymmetry;","GO:0005930|axoneme;GO:0097729|9+2 motile cilium;",".","K24728","CFAP52, WDR16; cilia- and flagella-associated protein 52"]
["ENSRNOG00000020353",76,4.889113302,226,14.59098028,0.335077781,-1.577432068,{"v":8.67151e-19,"d":"8.67E-19"},{"v":1.3469e-18,"d":"1.35E-18"},"down","yes","Sh3pxd2a","protein_coding","chr1:246160502-246360166:-","gi|564334037|ref|XP_006231575.1|",5299,0,"PREDICTED: SH3 and PX domain-containing protein 2A isoform X1 [Rattus norvegicus]","gi|672040467|ref|XM_006231513.2|",3790,0,"PREDICTED: Rattus norvegicus SH3 and PX domains 2A (Sh3pxd2a), transcript variant X1, mRNA","O89032",1977,0,"SH3 and PX domain-containing protein 2A",".",".",".",".","pfam00787","PX","PX domain. PX domains bind to phosphoinositides.","GO:0001701|in utero embryonic development;GO:0006801|superoxide metabolic process;GO:0042554|superoxide anion generation;GO:0050790|regulation of catalytic activity;GO:0072593|reactive oxygen species metabolic process;GO:0072675|osteoclast fusion;","GO:0002102|podosome;GO:0005737|cytoplasm;GO:0042995|cell projection;","GO:0002020|protease binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0010314|phosphatidylinositol-5-phosphate binding;GO:0016176|superoxide-generating NADPH oxidase activator activity;GO:0032266|phosphatidylinositol-3-phosphate binding;GO:0035091|phosphatidylinositol binding;GO:0043325|phosphatidylinositol-3,4-bisphosphate binding;GO:0070273|phosphatidylinositol-4-phosphate binding;","K24032","SH3PXD2; SH3 and PX domain-containing protein 2"]
["ENSRNOG00000037632",2,0.128660876,73,4.713015755,0.027299055,-5.195005178,{"v":8.6852e-19,"d":"8.69E-19"},{"v":1.3483E-18,"d":"1.35E-18"},"down","yes","ENSRNOG00000037632","protein_coding","chr14:83748478-83767435:+","gi|209571561|ref|NP_001129387.1|",1457,0,"uncharacterized protein C7orf57 homolog [Rattus norvegicus]","gi|209571560|ref|NM_001135915.1|",1454,0,"Rattus norvegicus hypothetical protein LOC688553 (LOC688553), mRNA",".",".",".",".",".",".",".",".","pfam14825","DUF4483","Domain of unknown function (DUF4483). This family of proteins is found in eukaryotes. Proteins in this family are typically between 203 and 326 amino acids in length. There is a single completely conserved residue N that may be functionally important.",".",".",".",".","."]
["ENSRNOG00000014987",119,7.655322144,295,19.0457486,0.401943883,-1.314934,{"v":1.12585e-18,"d":"1.13E-18"},{"v":1.74209E-18,"d":"1.74E-18"},"down","yes","Mdfi","protein_coding","chr9:13156866-13175217:+","gi|157817989|ref|NP_001102771.1|",894,{"v":7E-114,"d":"7.00E-114"},"myoD family inhibitor [Rattus norvegicus]","gi|157817988|ref|NM_001109301.1|",1616,0,"Rattus norvegicus MyoD family inhibitor (Mdfi), mRNA","Q99750",239,{"v":6e-73,"d":"6.00E-73"},"MyoD family inhibitor",".",".",".",".","pfam15316","MDFI","MyoD family inhibitor. Members of this family inhibits the transactivation activity of the MyoD family of myogenic factors. They affect axin-mediated regulation of the Wnt and JNK signaling pathways, and regulate expression from viral promoters.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0009950|dorsal/ventral axis specification;GO:0030111|regulation of Wnt signaling pathway;GO:0030178|negative regulation of Wnt signaling pathway;GO:0043392|negative regulation of DNA binding;GO:0046328|regulation of JNK cascade;GO:0048704|embryonic skeletal system morphogenesis;GO:0060707|trophoblast giant cell differentiation;","GO:0005634|nucleus;","GO:0008134|transcription factor binding;GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000026951",57,3.666834977,192,12.39587705,0.295810854,-1.757253106,{"v":1.25948e-18,"d":"1.26E-18"},{"v":1.9436e-18,"d":"1.94E-18"},"down","yes","Susd5","protein_coding","chr8:113997362-114035861:+","gi|293349517|ref|XP_001076682.2|",2935,0,"PREDICTED: sushi domain-containing protein 5 isoform X1 [Rattus norvegicus]","gi|672023382|ref|XM_001076682.4|",3956,0,"PREDICTED: Rattus norvegicus sushi domain containing 5 (Susd5), transcript variant X1, mRNA","O60279",799,0,"Sushi domain-containing protein 5",".",".",".",".","pfam00193","Xlink","Extracellular link domain.","GO:0007155|cell adhesion;GO:0007219|Notch signaling pathway;","GO:0016021|integral component of membrane;","GO:0005540|hyaluronic acid binding;","K23823","SUSD5; sushi domain-containing protein 5"]
["ENSRNOG00000016995",18,1.157947887,114,7.360052001,0.157328764,-2.668145632,{"v":1.34789E-18,"d":"1.35E-18"},{"v":2.07724e-18,"d":"2.08E-18"},"down","yes","Zap70","protein_coding","chr9:38989750-39011700:+","gi|564367964|ref|XP_006244823.1|",3224,0,"PREDICTED: tyrosine-protein kinase ZAP-70 isoform X2 [Rattus norvegicus]","gi|672064817|ref|XM_006244761.2|",2113,0,"PREDICTED: Rattus norvegicus zeta-chain (TCR) associated protein kinase 70 (Zap70), transcript variant X1, mRNA","P43404",1216,0,"Tyrosine-protein kinase ZAP-70",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0002250|adaptive immune response;GO:0006468|protein phosphorylation;GO:0006955|immune response;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0008150|biological_process;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0030154|cell differentiation;GO:0035556|intracellular signal transduction;GO:0043366|beta selection;GO:0045059|positive thymic T cell selection;GO:0045060|negative thymic T cell selection;GO:0045061|thymic T cell selection;GO:0045087|innate immune response;GO:0045582|positive regulation of T cell differentiation;GO:0046638|positive regulation of alpha-beta T cell differentiation;GO:0046641|positive regulation of alpha-beta T cell proliferation;GO:0046777|protein autophosphorylation;GO:0050850|positive regulation of calcium-mediated signaling;GO:0050852|T cell receptor signaling pathway;","GO:0001772|immunological synapse;GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0016020|membrane;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0042101|T cell receptor complex;GO:0045121|membrane raft;","GO:0001784|phosphotyrosine residue binding;GO:0003674|molecular_function;GO:0004672|protein kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0005102|signaling receptor binding;GO:0005524|ATP binding;","K07360","ZAP70; tyrosine-protein kinase ZAP-70 [EC:2.7.10.2]"]
["ENSRNOG00000015080",157,10.0998788,352,22.7257746,0.444423962,-1.169991489,{"v":1.464e-18,"d":"1.46E-18"},{"v":2.25131e-18,"d":"2.25E-18"},"down","yes","Wdfy1","protein_coding","chr9:81034849-81092775:-","gi|564368985|ref|XP_006245252.1|",2216,0,"PREDICTED: WD repeat and FYVE domain-containing protein 1 isoform X1 [Rattus norvegicus]","gi|672065571|ref|XM_006245190.2|",1268,0,"PREDICTED: Rattus norvegicus WD repeat and FYVE domain containing 1 (Wdfy1), transcript variant X1, mRNA","E9Q4P1",854,0,"WD repeat and FYVE domain-containing protein 1","all0283_3",90.1,{"v":1e-17,"d":"1.00E-17"},"COG2319","pfam01363","FYVE","FYVE zinc finger. The FYVE zinc finger is named after four proteins that it has been found in: Fab1, YOTB/ZK632.12, Vac1, and EEA1. The FYVE finger has been shown to bind two Zn++ ions. The FYVE finger has eight potential zinc coordinating cysteine positions. Many members of this family also include two histidines in a motif R+HHC+XCG, where + represents a charged residue and X any residue. We have included members which do not conserve these histidine residues but are clearly related.","GO:0034141|positive regulation of toll-like receptor 3 signaling pathway;GO:0034145|positive regulation of toll-like receptor 4 signaling pathway;","GO:0005634|nucleus;GO:0005769|early endosome;GO:0005829|cytosol;","GO:0005545|1-phosphatidylinositol binding;GO:0046872|metal ion binding;",".","."]
["ENSRNOG00000001584",103,6.626035133,268,17.30257839,0.382950736,-1.384769283,{"v":2.16209e-18,"d":"2.16E-18"},{"v":3.30877e-18,"d":"3.31E-18"},"down","yes","Map3k7cl","protein_coding","chr11:26791316-26835602:+","gi|564375979|ref|XP_006248078.1|",748,{"v":4E-92,"d":"4.00E-92"},"PREDICTED: TAK1-like protein isoform X1 [Rattus norvegicus]","gi|672070609|ref|XM_006248016.2|",1972,0,"PREDICTED: Rattus norvegicus MAP3K7 C-terminal like (Map3k7cl), transcript variant X1, mRNA","P58500",248,{"v":4e-77,"d":"4.00E-77"},"MAP3K7 C-terminal-like protein",".",".",".",".","pfam04111","APG6","Autophagy protein Apg6. In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway.",".",".",".",".","."]
["ENSRNOG00000045595",8,0.514643505,88,5.68144365,0.090583228,-3.464612238,{"v":2.19105E-18,"d":"2.19E-18"},{"v":3.35131e-18,"d":"3.35E-18"},"down","yes","Tnfsf9","protein_coding","chr9:1944017-1946345:+","gi|31077104|ref|NP_852049.1|",1569,0,"tumor necrosis factor ligand superfamily member 9 [Rattus norvegicus]","gi|31341223|ref|NM_181384.2|",1301,0,"Rattus norvegicus tumor necrosis factor superfamily member 9 (Tnfsf9), mRNA","P41274",486,{"v":5e-170,"d":"5.00E-170"},"Tumor necrosis factor ligand superfamily member 9",".",".",".",".","pfam00229","TNF","TNF(tumor Necrosis Factor) family.","GO:0006955|immune response;GO:0007165|signal transduction;GO:0032729|positive regulation of interferon-gamma production;GO:0032735|positive regulation of interleukin-12 production;GO:0032755|positive regulation of interleukin-6 production;GO:0042104|positive regulation of activated T cell proliferation;GO:0042127|regulation of cell proliferation;GO:0043011|myeloid dendritic cell differentiation;GO:0045585|positive regulation of cytotoxic T cell differentiation;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0005102|signaling receptor binding;GO:0005125|cytokine activity;GO:0005164|tumor necrosis factor receptor binding;GO:0032813|tumor necrosis factor receptor superfamily binding;","K05472","TNFSF9, CD137L; tumor necrosis factor ligand superfamily member 9"]
["ENSRNOG00000016756",23,1.479600078,124,8.005670597,0.184819006,-2.435814974,{"v":2.67232e-18,"d":"2.67E-18"},{"v":4.07977e-18,"d":"4.08E-18"},"down","yes","Ptgir","protein_coding","chr1:77579596-77581979:+","gi|117647216|ref|NP_001071112.1|",2044,0,"prostacyclin receptor [Rattus norvegicus]","gi|117647215|ref|NM_001077644.1|",1360,0,"Rattus norvegicus prostaglandin I2 (prostacyclin) receptor (IP) (Ptgir), mRNA","P43253",791,0,"Prostacyclin receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0006954|inflammatory response;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0010642|negative regulation of platelet-derived growth factor receptor signaling pathway;GO:0032496|response to lipopolysaccharide;GO:0048662|negative regulation of smooth muscle cell proliferation;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0016501|prostacyclin receptor activity;","K04263","PTGIR; prostacyclin receptor"]
["ENSRNOG00000002161",58,3.731165415,192,12.39587705,0.301000518,-1.732162125,{"v":2.74933e-18,"d":"2.75E-18"},{"v":4.19286e-18,"d":"4.19E-18"},"down","yes","Tlr6","protein_coding","chr14:43362164-43375685:+","gi|564383646|ref|XP_006251022.1|",4063,0,"PREDICTED: toll-like receptor 6 isoform X1 [Rattus norvegicus]","gi|672076173|ref|XM_006250960.2|",3567,0,"PREDICTED: Rattus norvegicus toll-like receptor 6 (Tlr6), transcript variant X1, mRNA","Q9EPW9",1358,0,"Toll-like receptor 6",".",".",".",".","pfam01582","TIR","TIR domain. The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.","GO:0001774|microglial cell activation;GO:0001775|cell activation;GO:0002224|toll-like receptor signaling pathway;GO:0002755|MyD88-dependent toll-like receptor signaling pathway;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0010628|positive regulation of gene expression;GO:0032493|response to bacterial lipoprotein;GO:0032717|negative regulation of interleukin-8 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0034136|negative regulation of toll-like receptor 2 signaling pathway;GO:0034150|toll-like receptor 6 signaling pathway;GO:0035666|TRIF-dependent toll-like receptor signaling pathway;GO:0042496|detection of diacyl bacterial lipopeptide;GO:0043032|positive regulation of macrophage activation;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043507|positive regulation of JUN kinase activity;GO:0045087|innate immune response;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0046209|nitric oxide metabolic process;GO:0050729|positive regulation of inflammatory response;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0071221|cellular response to bacterial lipopeptide;GO:0071726|cellular response to diacyl bacterial lipopeptide;GO:0140052|cellular response to oxidised low-density lipoprotein particle stimulus;GO:1900017|positive regulation of cytokine production involved in inflammatory response;GO:1900227|positive regulation of NLRP3 inflammasome complex assembly;GO:1903223|positive regulation of oxidative stress-induced neuron death;GO:1903428|positive regulation of reactive oxygen species biosynthetic process;GO:1904646|cellular response to amyloid-beta;","GO:0005794|Golgi apparatus;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;GO:0035355|Toll-like receptor 2-Toll-like receptor 6 protein complex;GO:0043235|receptor complex;GO:0045121|membrane raft;","GO:0003953|NAD+ nucleosidase activity;GO:0004888|transmembrane signaling receptor activity;GO:0005102|signaling receptor binding;GO:0035663|Toll-like receptor 2 binding;GO:0038023|signaling receptor activity;GO:0042498|diacyl lipopeptide binding;GO:0042802|identical protein binding;GO:0046982|protein heterodimerization activity;GO:0071723|lipopeptide binding;","K10169","TLR6, CD286; toll-like receptor 6"]
["ENSRNOG00000070957",1,0.064330438,70,4.519330176,0.014234507,-6.134463636,{"v":3.41221E-18,"d":"3.41E-18"},{"v":5.18578e-18,"d":"5.19E-18"},"down","yes","Mkrn2os","protein_coding","chr4:148644609-148652712:-","gi|672050927|ref|XP_008761485.1|",1243,{"v":1e-170,"d":"1.00E-170"},"PREDICTED: MKRN2 opposite strand protein isoform X1 [Rattus norvegicus]","gi|672050926|ref|XM_008763263.1|",923,0,"PREDICTED: Rattus norvegicus rCG29620-like (LOC100361147), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam01813","ATP-synt_D","ATP synthase subunit D. This is a family of subunit D form various ATP synthases including V-type H+ transporting and Na+ dependent. Subunit D is suggested to be an integral part of the catalytic sector of the V-ATPase.",".",".",".",".","."]
["ENSRNOG00000014746",167,10.74318318,364,23.50051691,0.457146675,-1.129270967,{"v":3.59444e-18,"d":"3.59E-18"},{"v":5.45693e-18,"d":"5.46E-18"},"down","yes","Dzip1l","protein_coding","chr8:100194999-100228988:+","gi|672062995|ref|XP_008764748.1|",3333,0,"PREDICTED: zinc finger protein DZIP1L isoform X1 [Rattus norvegicus]","gi|672062994|ref|XM_008766526.1|",3583,0,"PREDICTED: Rattus norvegicus DAZ interacting zinc finger protein 1-like (Dzip1l), transcript variant X2, mRNA","Q5XIA0",1230,0,"Zinc finger protein DZIP1L",".",".",".",".","pfam13815","Dzip-like_N","Iguana/Dzip1-like DAZ-interacting protein N-terminal. The DAZ gene-product - Deleted in Azoospermia - and a closely related sequence are required early in germ-cell development in order to maintain germ-cell populations. This family is the N-terminal region that is the only part of the protein in some fungi and lower metazoa.","GO:0007224|smoothened signaling pathway;GO:0021532|neural tube patterning;GO:0032880|regulation of protein localization;GO:0033365|protein localization to organelle;GO:0033504|floor plate development;GO:0060271|cilium assembly;GO:0061512|protein localization to cilium;GO:1905349|ciliary transition zone assembly;","GO:0005737|cytoplasm;GO:0005814|centriole;GO:0005930|axoneme;GO:0036064|ciliary basal body;","GO:0046872|metal ion binding;","K16470","DZIP1; zinc finger protein DZIP1"]
["ENSRNOG00000000522",7,0.450313067,84,5.423196211,0.083034626,-3.59014312,{"v":4.51617e-18,"d":"4.52E-18"},{"v":6.83809e-18,"d":"6.84E-18"},"down","yes","Cpne5","protein_coding","chr20:7206742-7288883:-","gi|569000237|ref|XP_006524312.1|",3067,0,"PREDICTED: copine-5 isoform X1 [Mus musculus]","gi|157821438|ref|NM_001107616.1|",3714,0,"Rattus norvegicus copine 5 (Cpne5), mRNA","Q8JZW4",1140,0,"Copine-5","YOR086c",55.1,2e-06,"COG5038","pfam07002","Copine","Copine. This family represents a conserved region approximately 180 residues long within eukaryotic copines. Copines are Ca(2+)-dependent phospholipid-binding proteins that are thought to be involved in membrane-trafficking, and may also be involved in cell division and growth.","GO:0071277|cellular response to calcium ion;GO:1903861|positive regulation of dendrite extension;","GO:0005886|plasma membrane;GO:0043005|neuron projection;GO:0043025|neuronal cell body;","GO:0005544|calcium-dependent phospholipid binding;","K24523","CPNE5_8_9; copine 5/8/9"]
["ENSRNOG00000021011",7,0.450313067,84,5.423196211,0.083034626,-3.59014312,{"v":4.51617e-18,"d":"4.52E-18"},{"v":6.83809e-18,"d":"6.84E-18"},"down","yes","Fut2","protein_coding","chr1:96119371-96140360:-","gi|13994175|ref|NP_113823.1|",1912,0,"galactoside 2-alpha-L-fucosyltransferase 2 [Rattus norvegicus]","gi|672036582|ref|XM_006229135.2|",2920,0,"PREDICTED: Rattus norvegicus fucosyltransferase 2 (secretor status included) (Fut2), transcript variant X1, mRNA","Q10984",739,0,"Galactoside 2-alpha-L-fucosyltransferase 2",".",".",".",".","pfam01531","Glyco_transf_11","Glycosyl transferase family 11. This family contains several fucosyl transferase enzymes.","GO:0001936|regulation of endothelial cell proliferation;GO:0005975|carbohydrate metabolic process;GO:0006486|protein glycosylation;GO:0006664|glycolipid metabolic process;GO:0030155|regulation of cell adhesion;GO:0036065|fucosylation;","GO:0016021|integral component of membrane;GO:0032580|Golgi cisterna membrane;","GO:0008107|galactoside 2-alpha-L-fucosyltransferase activity;GO:0008417|fucosyltransferase activity;GO:0031127|alpha-(1,2)-fucosyltransferase activity;","K00718","FUT1_2; galactoside 2-L-fucosyltransferase 1/2 [EC:2.4.1.69]"]
["ENSRNOG00000020872",12,0.771965258,97,6.262500387,0.123267898,-3.020130961,{"v":5.32424e-18,"d":"5.32E-18"},{"v":8.04455e-18,"d":"8.04E-18"},"down","yes","Cd5","protein_coding","chr1:207365337-207386313:-","gi|149062413|gb|EDM12836.1|",2216,0,"CD5 antigen, isoform CRA_b [Rattus norvegicus]","gi|9506470|ref|NM_019295.1|",2016,0,"Rattus norvegicus Cd5 molecule (Cd5), mRNA","P51882",857,0,"T-cell surface glycoprotein CD5",".",".",".",".","pfam00530","SRCR","Scavenger receptor cysteine-rich domain. These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.","GO:0006897|endocytosis;GO:0009966|regulation of signal transduction;GO:0031295|T cell costimulation;GO:0097190|apoptotic signaling pathway;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0044214|spanning component of plasma membrane;","GO:0005044|scavenger receptor activity;GO:0005515|protein binding;","K06455","CD5; T-cell surface glycoprotein CD5"]
["ENSRNOG00000014253",0,0.032165219,72,4.648453895,0.006919552,-7.175105621,{"v":7.04332e-18,"d":"7.04E-18"},{"v":1.05915e-17,"d":"1.06E-17"},"down","yes","Pax2","protein_coding","chr1:243616606-243695321:+","gi|829726259|ref|XP_012624358.1|",1910,0,"PREDICTED: paired box protein Pax-2 isoform X9 [Microcebus murinus]","gi|672040358|ref|XM_008760405.1|",1361,0,"PREDICTED: Rattus norvegicus paired box 2 (Pax2), transcript variant X4, mRNA","Q02962",706,0,"Paired box protein Pax-2",".",".",".",".","pfam00292","PAX","'Paired box' domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001655|urogenital system development;GO:0001656|metanephros development;GO:0001657|ureteric bud development;GO:0001658|branching involved in ureteric bud morphogenesis;GO:0001709|cell fate determination;GO:0001822|kidney development;GO:0001823|mesonephros development;GO:0001843|neural tube closure;GO:0002072|optic cup morphogenesis involved in camera-type eye development;GO:0003337|mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0003406|retinal pigment epithelium development;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007417|central nervous system development;GO:0007501|mesodermal cell fate specification;GO:0007568|aging;GO:0008284|positive regulation of cell proliferation;GO:0010001|glial cell differentiation;GO:0021554|optic nerve development;GO:0021631|optic nerve morphogenesis;GO:0021633|optic nerve structural organization;GO:0021650|vestibulocochlear nerve formation;GO:0031016|pancreas development;GO:0031667|response to nutrient levels;GO:0035566|regulation of metanephros size;GO:0035799|ureter maturation;GO:0039003|pronephric field specification;GO:0042472|inner ear morphogenesis;GO:0042981|regulation of apoptotic process;GO:0043010|camera-type eye development;GO:0043066|negative regulation of apoptotic process;GO:0043067|regulation of programmed cell death;GO:0043069|negative regulation of programmed cell death;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043491|protein kinase B signaling;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048793|pronephros development;GO:0048854|brain morphogenesis;GO:0048856|anatomical structure development;GO:0048863|stem cell differentiation;GO:0050679|positive regulation of epithelial cell proliferation;GO:0060231|mesenchymal to epithelial transition;GO:0061205|paramesonephric duct development;GO:0061360|optic chiasma development;GO:0070301|cellular response to hydrogen peroxide;GO:0071260|cellular response to mechanical stimulus;GO:0071300|cellular response to retinoic acid;GO:0071333|cellular response to glucose stimulus;GO:0071364|cellular response to epidermal growth factor stimulus;GO:0072075|metanephric mesenchyme development;GO:0072108|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0072162|metanephric mesenchymal cell differentiation;GO:0072164|mesonephric tubule development;GO:0072172|mesonephric tubule formation;GO:0072177|mesonephric duct development;GO:0072179|nephric duct formation;GO:0072189|ureter development;GO:0072197|ureter morphogenesis;GO:0072205|metanephric collecting duct development;GO:0072207|metanephric epithelium development;GO:0072221|metanephric distal convoluted tubule development;GO:0072289|metanephric nephron tubule formation;GO:0072300|positive regulation of metanephric glomerulus development;GO:0072305|negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis;GO:0072307|regulation of metanephric nephron tubule epithelial cell differentiation;GO:0072593|reactive oxygen species metabolic process;GO:0090102|cochlea development;GO:0090103|cochlea morphogenesis;GO:0090190|positive regulation of branching involved in ureteric bud morphogenesis;GO:1900212|negative regulation of mesenchymal cell apoptotic process involved in metanephros development;GO:1900215|negative regulation of apoptotic process involved in metanephric collecting duct development;GO:1900218|negative regulation of apoptotic process involved in metanephric nephron tubule development;GO:2000378|negative regulation of reactive oxygen species metabolic process;GO:2000594|positive regulation of metanephric DCT cell differentiation;GO:2000597|positive regulation of optic nerve formation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005764|lysosome;GO:0005815|microtubule organizing center;GO:0032991|protein-containing complex;GO:0032993|protein-DNA complex;GO:0034451|centriolar satellite;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987|proximal promoter sequence-specific DNA binding;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0070742|C2H2 zinc finger domain binding;GO:1990837|sequence-specific double-stranded DNA binding;","K15608","PAX2; paired box protein 2"]
["ENSRNOG00000025354",19,1.222278326,113,7.295490141,0.167538891,-2.577432068,{"v":8.02924e-18,"d":"8.03E-18"},{"v":1.20551E-17,"d":"1.21E-17"},"down","yes","Rinl","protein_coding","chr1:84077265-84088330:+","gi|564327101|ref|XP_006228716.1|",2681,0,"PREDICTED: ras and Rab interactor-like protein isoform X2 [Rattus norvegicus]","gi|157819766|ref|NM_001106241.1|",2990,0,"Rattus norvegicus Ras and Rab interactor-like (Rinl), mRNA","Q80UW3",846,0,"Ras and Rab interactor-like protein",".",".",".",".","pfam02204","VPS9","Vacuolar sorting protein 9 (VPS9) domain. This domain acts as a GDP-GTP exchange factor (GEF). It activates Rab GTPases by stimulating the release of GDP and allowing GTP to bind.","GO:0006897|endocytosis;GO:0050790|regulation of catalytic activity;","GO:0001726|ruffle;GO:0015629|actin cytoskeleton;","GO:0005085|guanyl-nucleotide exchange factor activity;",".","."]
["ENSRNOG00000013017",146,9.392243975,330,21.30541369,0.440838376,-1.181678275,{"v":9.41823e-18,"d":"9.42E-18"},{"v":1.40923E-17,"d":"1.41E-17"},"down","yes","Arnt2","protein_coding","chr1:138189940-138393153:-","gi|1470080|gb|AAB05247.1|",2892,0,"aryl hydrocarbon receptor nuclear translocator 2, partial [Rattus norvegicus]","gi|672037414|ref|XM_008759608.1|",4960,0,"PREDICTED: Rattus norvegicus aryl hydrocarbon receptor nuclear translocator 2 (Arnt2), transcript variant X12, mRNA","Q78E60",1117,0,"Aryl hydrocarbon receptor nuclear translocator 2","all0219_1",55.8,1e-07,"COG2202","pfam14598","PAS_11","PAS domain. This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).","GO:0001666|response to hypoxia;GO:0001701|in utero embryonic development;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007417|central nervous system development;GO:0007420|brain development;GO:0008284|positive regulation of cell proliferation;GO:0032355|response to estradiol;GO:0043066|negative regulation of apoptotic process;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005737|cytoplasm;GO:0034751|aryl hydrocarbon receptor complex;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0017162|aryl hydrocarbon receptor binding;GO:0044877|protein-containing complex binding;GO:0046982|protein heterodimerization activity;GO:1990837|sequence-specific double-stranded DNA binding;","K15589","ARNT2; aryl hydrocarbon receptor nuclear translocator 2"]
["ENSRNOG00000001618",0,0.032165219,71,4.583892036,0.007017011,-7.154927739,{"v":1.12878e-17,"d":"1.13E-17"},{"v":1.68368E-17,"d":"1.68E-17"},"down","yes","Ripk4","protein_coding","chr11:37122565-37144799:-","gi|157819567|ref|NP_001100573.1|",3657,0,"receptor-interacting serine/threonine-protein kinase 4 [Rattus norvegicus]","gi|157819566|ref|NM_001107103.1|",3580,0,"Rattus norvegicus receptor-interacting serine-threonine kinase 4 (Ripk4), mRNA","Q9ERK0",1388,0,"Receptor-interacting serine/threonine-protein kinase 4","all2748",129,{"v":2e-30,"d":"2.00E-30"},"COG0666","pfam00069","Pkinase","Protein kinase domain.","GO:0002009|morphogenesis of an epithelium;GO:0006468|protein phosphorylation;GO:0051092|positive regulation of NF-kappaB transcription factor activity;","GO:0005737|cytoplasm;","GO:0004672|protein kinase activity;GO:0005524|ATP binding;","K08848","RIPK4; receptor-interacting serine/threonine-protein kinase 4 [EC:2.7.11.1]"]
["ENSRNOG00000011598",3,0.192991315,71,4.583892036,0.042102064,-4.569965238,{"v":1.15896E-17,"d":"1.16E-17"},{"v":1.7278E-17,"d":"1.73E-17"},"down","yes","ENSRNOG00000011598","protein_coding","chr15:98537641-98582545:-","gi|1136776|dbj|BAA08844.1|",3660,0,"proton-coupled dipeptide cotransporter [Rattus norvegicus]","gi|1136775|dbj|D50306.1|RATPCDC",2854,0,"Rattus norvegicus mRNA for proton-coupled dipeptide cotransporter, complete cds","P51574",1405,0,"Solute carrier family 15 member 1","ECU11g1050",199,{"v":3e-54,"d":"3.00E-54"},"COG3104","pfam00854","PTR2","POT family. The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.","GO:0006857|oligopeptide transport;GO:0015031|protein transport;GO:0051956|negative regulation of amino acid transport;GO:0140206|dipeptide import across plasma membrane;GO:1902600|proton transmembrane transport;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005903|brush border;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;","GO:0005427|proton-dependent oligopeptide secondary active transmembrane transporter activity;GO:0015333|peptide:proton symporter activity;GO:0016248|channel inhibitor activity;GO:0071916|dipeptide transmembrane transporter activity;","K14206","SLC15A1, PEPT1; solute carrier family 15 (oligopeptide transporter), member 1"]
["ENSRNOG00000008133",187,12.02979194,389,25.11456341,0.478996658,-1.061912504,{"v":1.25526e-17,"d":"1.26E-17"},{"v":1.86892e-17,"d":"1.87E-17"},"down","yes","Mfng","protein_coding","chr7:110310812-110328653:-","gi|149065980|gb|EDM15853.1|",1626,0,"manic fringe homolog (Drosophila) [Rattus norvegicus]","gi|40018595|ref|NM_199110.1|",1749,0,"Rattus norvegicus MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (Mfng), mRNA","O09008",594,0,"Beta-1,3-N-acetylglucosaminyltransferase manic fringe",".",".",".",".","pfam02434","Fringe","Fringe-like. The drosophila protein fringe (FNG) is a glucosaminyltransferase that controls the response of the Notch receptor to specific ligands. FNG is localized to the Golgi apparatus (not secreted as previously thought). Modification of Notch occurs through glycosylation by FNG. The xenopus homologue, lunatic fringe, has been implicated in a variety of functions.","GO:0001825|blastocyst formation;GO:0002315|marginal zone B cell differentiation;GO:0008150|biological_process;GO:0008593|regulation of Notch signaling pathway;GO:0032092|positive regulation of protein binding;GO:0045747|positive regulation of Notch signaling pathway;","GO:0005575|cellular_component;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0008375|acetylglucosaminyltransferase activity;GO:0033829|O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity;","K05948","FNG; fringe [EC:2.4.1.222]"]
["ENSRNOG00000009487",19,1.222278326,112,7.230928281,0.169034774,-2.564608028,{"v":1.37282e-17,"d":"1.37E-17"},{"v":2.04235e-17,"d":"2.04E-17"},"down","yes","Gpr160","protein_coding","chr2:112484935-112563148:-","gi|68341997|ref|NP_001020318.1|",1578,0,"probable G-protein coupled receptor 160 [Rattus norvegicus]","gi|672042140|ref|XM_008760935.1|",2513,0,"PREDICTED: Rattus norvegicus G protein-coupled receptor 160 (Gpr160), transcript variant X1, mRNA","Q66H29",612,0,"Probable G-protein coupled receptor 160",".",".",".",".","pfam06736","DUF1211","Protein of unknown function (DUF1211). This family represents a conserved region within a number of hypothetical proteins of unknown function found in eukaryotes, bacteria and archaea. These may possibly be integral membrane proteins.","GO:0007186|G protein-coupled receptor signaling pathway;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0043235|receptor complex;","GO:0004930|G protein-coupled receptor activity;","K08438","GPR160; G protein-coupled receptor 160"]
["ENSRNOG00000000525",163,10.48586142,353,22.79033646,0.460101212,-1.119976838,{"v":1.86582e-17,"d":"1.87E-17"},{"v":2.76714e-17,"d":"2.77E-17"},"down","yes","Pi16","protein_coding","chr20:7376126-7385383:+","gi|281427227|ref|NP_001163952.1|",2025,0,"peptidase inhibitor 16 precursor [Rattus norvegicus]","gi|564397203|ref|XR_362046.1|",2399,0,"PREDICTED: Rattus norvegicus peptidase inhibitor 16 (Pi16), transcript variant X1, misc_RNA","Q9ET66",667,0,"Peptidase inhibitor 16","YJL078c_1",71.6,{"v":3e-13,"d":"3.00E-13"},"COG2340","pfam00188","CAP","Cysteine-rich secretory protein family. This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organisms, including prokaryotes and non-vertebrate eukaryotes, The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumor suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilisation. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The Ca++-chelating function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how helothermine from Heloderma horridum horridum blocks the Ca++ transporting ryanodine receptors.","GO:0061052|negative regulation of cell growth involved in cardiac muscle cell development;","GO:0005615|extracellular space;",".","K20412","PI16, CRISP9, CD364; peptidase inhibitor 16"]
["ENSRNOG00000018953",4,0.257321753,73,4.713015755,0.05459811,-4.195005178,{"v":1.90541e-17,"d":"1.91E-17"},{"v":2.82366E-17,"d":"2.82E-17"},"down","yes","Cblc","protein_coding","chr1:79439977-79456755:-","gi|576011138|sp|G3V8H4.1|CBLC_RAT",2535,0,"RecName: Full=E3 ubiquitin-protein ligase CBL-C","gi|240255493|ref|NM_001034920.2|",1651,0,"Rattus norvegicus Cbl proto-oncogene C, E3 ubiquitin protein ligase (Cblc), mRNA","G3V8H4",959,0,"E3 ubiquitin-protein ligase CBL-C",".",".",".",".","pfam02762","Cbl_N3","CBL proto-oncogene N-terminus, SH2-like domain. Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. The so called N-terminal domain is actually 3 structural domains, of which this is the C-terminal SH2 domain.","GO:0006511|ubiquitin-dependent protein catabolic process;GO:0007165|signal transduction;GO:0007166|cell surface receptor signaling pathway;GO:0007175|negative regulation of epidermal growth factor-activated receptor activity;GO:0016567|protein ubiquitination;GO:0042059|negative regulation of epidermal growth factor receptor signaling pathway;GO:0043407|negative regulation of MAP kinase activity;","GO:0005886|plasma membrane;GO:0045121|membrane raft;","GO:0001784|phosphotyrosine residue binding;GO:0005154|epidermal growth factor receptor binding;GO:0005509|calcium ion binding;GO:0017124|SH3 domain binding;GO:0030971|receptor tyrosine kinase binding;GO:0061630|ubiquitin protein ligase activity;","K22518","CBLC; E3 ubiquitin-protein ligase CBL-C [EC:2.3.2.27]"]
["ENSRNOG00000038202",15,0.964956573,102,6.585309685,0.146531692,-2.770715366,{"v":2.00862E-17,"d":"2.01E-17"},{"v":2.97276e-17,"d":"2.97E-17"},"down","yes","Calml4","protein_coding","chr8:63323351-63335234:+","gi|148694085|gb|EDL26032.1|",895,{"v":5e-118,"d":"5.00E-118"},"calmodulin-like 4, isoform CRA_c [Mus musculus]","gi|189011706|ref|NM_001127575.1|",896,0,"Rattus norvegicus calmodulin-like 4 (Calml4), mRNA","Q91WQ9",311,{"v":5e-105,"d":"5.00E-105"},"Calmodulin-like protein 4","SPAC3A12.14",116,{"v":3e-30,"d":"3.00E-30"},"COG5126","pfam13499","EF-hand_7","EF-hand domain pair.","GO:0050790|regulation of catalytic activity;",".","GO:0005509|calcium ion binding;GO:0030234|enzyme regulator activity;","K02183","CALM; calmodulin"]
["ENSRNOG00000048275",11,0.70763482,92,5.939691088,0.119136637,-3.069310957,{"v":2.15884e-17,"d":"2.16E-17"},{"v":3.19178e-17,"d":"3.19E-17"},"down","yes","RGD1309350","protein_coding","chr1:195905763-195909159:+","gi|197381585|ref|NP_001127979.1|",752,{"v":9e-98,"d":"9.00E-98"},"5-hydroxyisourate hydrolase [Rattus norvegicus]","gi|197381584|ref|NM_001134507.1|",839,0,"Rattus norvegicus similar to transthyretin (4L369) (RGD1309350), mRNA","Q9CRB3",235,{"v":2e-76,"d":"2.00E-76"},"5-hydroxyisourate hydrolase","AGc4223",97.1,{"v":6e-24,"d":"6.00E-24"},"COG2351","pfam00576","Transthyretin","HIUase/Transthyretin family. This family includes transthyretin that is a thyroid hormone-binding protein that transports thyroxine from the bloodstream to the brain. However, most of the sequences listed in this family do not bind thyroid hormones. They are actually enzymes of the purine catabolism that catalyse the conversion of 5-hydroxyisourate (HIU) to OHCU. HIU hydrolysis is the original function of the family and is conserved from bacteria to mammals; transthyretins arose by gene duplications in the vertebrate lineage. HIUases are distinguished in the alignment from the conserved C-terminal YRGS sequence.","GO:0006144|purine nucleobase metabolic process;",".","GO:0033971|hydroxyisourate hydrolase activity;","K07127","uraH, pucM, hiuH; 5-hydroxyisourate hydrolase [EC:3.5.2.17]"]
["ENSRNOG00000006353",54,3.473843662,179,11.55657288,0.300594623,-1.734108894,{"v":3.53041e-17,"d":"3.53E-17"},{"v":5.18602e-17,"d":"5.19E-17"},"down","yes","Large2","protein_coding","chr3:78336056-78342184:-","gi|564341884|ref|XP_006234626.1|",3391,0,"PREDICTED: glycosyltransferase-like protein LARGE2 isoform X2 [Rattus norvegicus]","gi|672046277|ref|XM_006234564.2|",2399,0,"PREDICTED: Rattus norvegicus glycosyltransferase-like 1B (Gyltl1b), transcript variant X4, mRNA","Q6P7A1",1303,0,"LARGE xylosyl- and glucuronyltransferase 2",".",".",".",".","pfam13896","Glyco_transf_49","Glycosyl-transferase for dystroglycan. This glycosyl-transferase brings about the glycosylation of the alpha-dystroglycan subunit. Dystroglycan is an integral member of the skeletal muscular dystrophin glycoprotein complex, which links dystrophin to proteins in the extracellular matrix.","GO:0035269|protein O-linked mannosylation;","GO:0000139|Golgi membrane;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0002162|dystroglycan binding;GO:0015020|glucuronosyltransferase activity;GO:0016757|transferase activity, transferring glycosyl groups;GO:0042285|xylosyltransferase activity;GO:0046872|metal ion binding;","K09668","LARGE; glycosyltransferase-like protein LARGE [EC:2.4.2.- 2.4.1.-]"]
["ENSRNOG00000021090",84,5.403756808,230,14.84922772,0.363908272,-1.458353248,{"v":3.54388e-17,"d":"3.54E-17"},{"v":5.20448e-17,"d":"5.20E-17"},"down","yes","Pygm","protein_coding","chr1:203690533-203705368:+","gi|564332022|ref|XP_006230740.1|",4534,0,"PREDICTED: glycogen phosphorylase, muscle form isoform X1 [Rattus norvegicus]","gi|672039177|ref|XM_006230678.2|",2849,0,"PREDICTED: Rattus norvegicus phosphorylase, glycogen, muscle (Pygm), transcript variant X1, mRNA","Q9WUB3",1696,0,"Glycogen phosphorylase, muscle form","CPn0307",855,0,"COG0058","pfam00343","Phosphorylase","Carbohydrate phosphorylase. The members of this family catalyse the formation of glucose 1-phosphate from one of the following polyglucoses; glycogen, starch, glucan or maltodextrin.","GO:0001666|response to hypoxia;GO:0005977|glycogen metabolic process;GO:0005980|glycogen catabolic process;GO:0006874|cellular calcium ion homeostasis;GO:0010033|response to organic substance;GO:0051591|response to cAMP;","GO:0005737|cytoplasm;GO:0016529|sarcoplasmic reticulum;","GO:0008184|glycogen phosphorylase activity;GO:0016208|AMP binding;GO:0030170|pyridoxal phosphate binding;GO:0030246|carbohydrate binding;GO:0097159|organic cyclic compound binding;GO:0102250|linear malto-oligosaccharide phosphorylase activity;GO:0102499|SHG alpha-glucan phosphorylase activity;","K00688","PYG, glgP; glycogen phosphorylase [EC:2.4.1.1]"]
["ENSRNOG00000005076",161,10.35720055,348,22.46752716,0.460985336,-1.117207237,{"v":3.61993e-17,"d":"3.62E-17"},{"v":5.30934e-17,"d":"5.31E-17"},"down","yes","Bcorl1","protein_coding","chrX:127537538-127584087:+","gi|300797585|ref|NP_001178516.1|",6706,0,"BCL-6 corepressor-like protein 1 [Rattus norvegicus]","gi|672088535|ref|XM_006257523.2|",6851,0,"PREDICTED: Rattus norvegicus BCL6 co-repressor-like 1 (Bcorl1), transcript variant X1, mRNA","A2AQH4",2512,0,"BCL-6 corepressor-like protein 1",".",".",".",".","pfam12796","Ank_2","Ankyrin repeats (3 copies).",".","GO:0005654|nucleoplasm;GO:0005886|plasma membrane;",".",".","."]
["ENSRNOG00000019403",201,12.93041808,405,26.14755316,0.494517326,-1.015907026,{"v":4.07611e-17,"d":"4.08E-17"},{"v":5.96463e-17,"d":"5.96E-17"},"down","yes","Afap1l1","protein_coding","chr18:55183786-55244146:-","gi|564393652|ref|XP_006254856.1|",3736,0,"PREDICTED: actin filament-associated protein 1-like 1 isoform X1 [Rattus norvegicus]","gi|672083374|ref|XM_006254794.2|",3439,0,"PREDICTED: Rattus norvegicus actin filament associated protein 1-like 1 (Afap1l1), transcript variant X1, mRNA","D4AB98",1440,0,"Actin filament-associated protein 1-like 1",".",".",".",".","pfam00169","PH","PH domain. PH stands for pleckstrin homology.",".","GO:0002102|podosome;GO:0005829|cytosol;GO:0030054|cell junction;GO:0042995|cell projection;","GO:0017124|SH3 domain binding;","K23782","AFAP1L; actin filament associated protein 1-like"]
["ENSRNOG00000008570",10,0.643304382,88,5.68144365,0.113229035,-3.142684143,{"v":4.88491e-17,"d":"4.88E-17"},{"v":7.11715e-17,"d":"7.12E-17"},"down","yes","Cadps","protein_coding","chr15:12290262-12742779:+","gi|982235320|ref|XP_015301635.1|",6481,0,"PREDICTED: calcium-dependent secretion activator 1 isoform X17 [Macaca fascicularis]","gi|110825967|ref|NM_012061.3|",3814,0,"Mus musculus Ca2+-dependent secretion activator (Cadps), transcript variant 1, mRNA","Q9ULU8",2422,0,"Calcium-dependent secretion activator 1",".",".",".",".","pfam06292","DUF1041","Domain of Unknown Function (DUF1041). This family consists of several eukaryotic domains of unknown function. Members of this family are often found in tandem repeats and co-occur with pfam00168, pfam00130 and pfam00169 domains.","GO:0006887|exocytosis;GO:0015031|protein transport;GO:0016050|vesicle organization;GO:0016082|synaptic vesicle priming;GO:0045055|regulated exocytosis;GO:0045921|positive regulation of exocytosis;GO:0045956|positive regulation of calcium ion-dependent exocytosis;GO:0050432|catecholamine secretion;GO:0099525|presynaptic dense core vesicle exocytosis;","GO:0031045|dense core granule;GO:0031410|cytoplasmic vesicle;GO:0098674|extrinsic component of neuronal dense core vesicle membrane;GO:0098793|presynapse;GO:0098978|glutamatergic synapse;","GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0019901|protein kinase binding;GO:0046872|metal ion binding;","K19933","CADPS; calcium-dependent secretion activator"]
["ENSRNOG00000000251",1,0.064330438,65,4.196520878,0.015329469,-6.027548432,{"v":4.92735e-17,"d":"4.93E-17"},{"v":7.16984e-17,"d":"7.17E-17"},"down","yes","St6galnac1","protein_coding","chr10:101972668-101983053:-","gi|157786730|ref|NP_001099329.1|",2609,0,"alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 precursor [Rattus norvegicus]","gi|157786729|ref|NM_001105859.1|",2420,0,"Rattus norvegicus ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (St6galnac1), mRNA","Q9QZ39",801,0,"Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1",".",".",".",".","pfam00777","Glyco_transf_29","Glycosyltransferase family 29 (sialyltransferase). Members of this family belong to glycosyltransferase family 29.","GO:0006486|protein glycosylation;GO:0009312|oligosaccharide biosynthetic process;GO:0097503|sialylation;","GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;","GO:0001665|alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity;","K03479","SIAT7A, ST6GalNAc I; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7A) [EC:2.4.99.3]"]
["ENSRNOG00000047306",178,11.450818,371,23.95244993,0.478064583,-1.064722565,{"v":5.97878e-17,"d":"5.98E-17"},{"v":8.67107e-17,"d":"8.67E-17"},"down","yes","Stap2","protein_coding","chr9:828372-837219:-","gi|68163539|ref|NP_001020197.1|",1567,0,"signal-transducing adaptor protein 2 [Rattus norvegicus]","gi|68163538|ref|NM_001025026.1|",1049,0,"Rattus norvegicus signal transducing adaptor family member 2 (Stap2), mRNA","Q8R0L1",578,0,"Signal-transducing adaptor protein 2",".",".",".",".","pfam13088","BNR_2","BNR repeat-like domain. This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.",".","GO:0005886|plasma membrane;","GO:0035591|signaling adaptor activity;","K24026","STAP2; signal-transducing adaptor protein 2"]
["ENSRNOG00000004603",179,11.51514844,372,24.01701179,0.479458,-1.060523653,{"v":6.8293e-17,"d":"6.83E-17"},{"v":9.87699e-17,"d":"9.88E-17"},"down","yes","Srgap1","protein_coding","chr7:57329532-57596196:-","gi|300796374|ref|NP_001178713.1|",5508,0,"SLIT-ROBO Rho GTPase-activating protein 1 [Rattus norvegicus]","gi|672058791|ref|XM_008765402.1|",7557,0,"PREDICTED: Rattus norvegicus SLIT-ROBO Rho GTPase activating protein 1 (Srgap1), transcript variant X1, mRNA","Q7Z6B7",2080,0,"SLIT-ROBO Rho GTPase-activating protein 1",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0007266|Rho protein signal transduction;GO:0016477|cell migration;GO:0030336|negative regulation of cell migration;GO:0050790|regulation of catalytic activity;","GO:0005737|cytoplasm;","GO:0005096|GTPase activator activity;GO:0031267|small GTPase binding;","K07526","SRGAP; SLIT-ROBO Rho GTPase activating protein"]
["ENSRNOG00000042825",145,9.327913537,322,20.78891881,0.448696424,-1.156188407,{"v":8.07976e-17,"d":"8.08E-17"},{"v":1.16413E-16,"d":"1.16E-16"},"down","yes","Cd300le","protein_coding","chr10:100271036-100280299:-","gi|320498033|ref|NP_001189392.1|",945,{"v":3e-126,"d":"3.00E-126"},"Cd300 molecule-like family member E precursor [Rattus norvegicus]","gi|320498032|ref|NM_001202463.1|",691,0,"Rattus norvegicus Cd300 molecule-like family member E (Cd300le), mRNA","Q6SJQ5",303,{"v":1e-101,"d":"1.00E-101"},"CMRF35-like molecule 3",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004888|transmembrane signaling receptor activity;","K20395","CD300B_D_F; CO300B/D/F antigen"]
["ENSRNOG00000007585",15,0.964956573,99,6.391624106,0.150972047,-2.727646644,{"v":1.04902E-16,"d":"1.05E-16"},{"v":1.5061E-16,"d":"1.51E-16"},"down","yes","Hoxb8","protein_coding","chr10:81248887-81250638:+","gi|21362265|ref|NP_034591.1|",1095,{"v":1e-147,"d":"1.00E-147"},"homeobox protein Hox-B8 [Mus musculus]","gi|300793661|ref|NM_001191649.1|",973,0,"Rattus norvegicus homeo box B8 (Hoxb8), mRNA","P09632",426,{"v":5e-149,"d":"5.00E-149"},"Homeobox protein Hox-B8","YDL106c",50.8,3e-06,"COG5576","pfam00046","Homeobox","Homeobox domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007625|grooming behavior;GO:0008344|adult locomotory behavior;GO:0009952|anterior/posterior pattern specification;GO:0019233|sensory perception of pain;GO:0021516|dorsal spinal cord development;GO:0045638|negative regulation of myeloid cell differentiation;GO:0048704|embryonic skeletal system morphogenesis;GO:0048705|skeletal system morphogenesis;","GO:0005634|nucleus;GO:0005654|nucleoplasm;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09308","HOX_8; homeobox protein HoxB/C/D8"]
["ENSRNOG00000003992",92,5.918400313,240,15.49484632,0.381959278,-1.388509259,{"v":1.0780199999999999E-16,"d":"1.08E-16"},{"v":1.54735e-16,"d":"1.55E-16"},"down","yes","Pik3r6","protein_coding","chr10:53205496-53255243:+","gi|672068001|ref|XP_008766073.1|",3799,0,"PREDICTED: phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [Rattus norvegicus]","gi|672068000|ref|XM_008767851.1|",2997,0,"PREDICTED: Rattus norvegicus phosphoinositide-3-kinase, regulatory subunit 6 (Pik3r6), transcript variant X1, mRNA","Q3U6Q4",1384,0,"Phosphoinositide 3-kinase regulatory subunit 6",".",".",".",".","pfam10486","PI3K_1B_p101","Phosphoinositide 3-kinase gamma adapter protein p101 subunit. Class I PI3Ks are dual-specific lipid and protein kinases involved in numerous intracellular signaling pathways. Class IB PI3K, p110gamma, is mainly activated by seven-transmembrane G-protein-coupled receptors (GPCRs), through its regulatory subunit p101 and G-protein beta-gamma subunits.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0042269|regulation of natural killer cell mediated cytotoxicity;GO:0043406|positive regulation of MAP kinase activity;GO:0043551|regulation of phosphatidylinositol 3-kinase activity;GO:0045582|positive regulation of T cell differentiation;GO:0045766|positive regulation of angiogenesis;GO:0046854|phosphatidylinositol phosphorylation;","GO:0005942|phosphatidylinositol 3-kinase complex;GO:0005944|phosphatidylinositol 3-kinase complex, class IB;GO:0016020|membrane;","GO:0046934|phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0046935|1-phosphatidylinositol-3-kinase regulator activity;","K21290","PIK3R5_6; phosphoinositide-3-kinase regulatory subunit 5/6"]
["ENSRNOG00000024569",76,4.889113302,214,13.81623797,0.35386719,-1.498720092,{"v":1.08175E-16,"d":"1.08E-16"},{"v":1.55231E-16,"d":"1.55E-16"},"down","yes","Gimap9","protein_coding","chr4:77626138-77629497:+","gi|56676322|ref|NP_001008399.1|",1444,0,"GTPase, IMAP family member 9 [Rattus norvegicus]","gi|73909202|gb|BC103635.1|",1700,0,"Rattus norvegicus GTPase, IMAP family member 9, mRNA (cDNA clone MGC:124918 IMAGE:7100941), complete cds","Q8NHV1",306,{"v":6e-96,"d":"6.00E-96"},"GTPase IMAP family member 7",".",".",".",".","pfam04548","AIG1","AIG1 family. Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.",".","GO:0005829|cytosol;","GO:0005525|GTP binding;",".","."]
["ENSRNOG00000016998",69,4.438800235,202,13.04149565,0.340359753,-1.554867645,{"v":1.2267E-16,"d":"1.23E-16"},{"v":1.75811e-16,"d":"1.76E-16"},"down","yes","Atxn1","protein_coding","chr17:18737533-19142360:+","gi|6981504|ref|NP_036858.1|",3837,0,"ataxin-1 [Rattus norvegicus]","gi|126506307|ref|NM_012726.2|",4662,0,"Rattus norvegicus ataxin 1 (Atxn1), mRNA","Q63540",1482,0,"Ataxin-1",".",".",".",".","pfam08517","AXH","Ataxin-1 and HBP1 module (AXH). AXH is a protein-protein and RNA binding motif found in Ataxin-1 (ATX1). ATX1 is responsible for the autosomal-dominant neurodegenerative disorder Spinocerebellar ataxia type-1 (SCA1) in humans. The AXH module has also been identified in the apparently unrelated transcription factor HBP1 which is thought to be involved in the architectural regulation of chromatin and in specific gene expression.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006355|regulation of transcription, DNA-templated;GO:0007399|nervous system development;GO:0007420|brain development;GO:0007612|learning;GO:0007613|memory;GO:0008150|biological_process;GO:0008344|adult locomotory behavior;GO:0008542|visual learning;GO:0035176|social behavior;GO:0042326|negative regulation of phosphorylation;GO:0043569|negative regulation of insulin-like growth factor receptor signaling pathway;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048286|lung alveolus development;GO:0048856|anatomical structure development;GO:0051168|nuclear export;GO:0060079|excitatory postsynaptic potential;GO:0060252|positive regulation of glial cell proliferation;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016363|nuclear matrix;GO:0032991|protein-containing complex;GO:0042405|nuclear inclusion body;GO:0098794|postsynapse;","GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003723|RNA binding;GO:0008022|protein C-terminus binding;GO:0008266|poly(U) RNA binding;GO:0034046|poly(G) binding;GO:0042802|identical protein binding;GO:0043621|protein self-association;","K23616","ATXN1_1L; ataxin 1/1L"]
["ENSRNOG00000013661",122,7.848313459,286,18.46469186,0.425044378,-1.234314619,{"v":1.35784E-16,"d":"1.36E-16"},{"v":1.94216e-16,"d":"1.94E-16"},"down","yes","Kif26a","protein_coding","chr6:131214861-131250320:+","gi|564357463|ref|XP_006240697.1|",8256,0,"PREDICTED: kinesin-like protein KIF26A isoform X1 [Rattus norvegicus]","gi|672057197|ref|XM_006240635.2|",6696,0,"PREDICTED: Rattus norvegicus kinesin family member 26A (Kif26a), transcript variant X1, mRNA","Q52KG5",2986,0,"Kinesin-like protein KIF26A","YGL216w",114,{"v":2e-24,"d":"2.00E-24"},"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0001560|regulation of cell growth by extracellular stimulus;GO:0009968|negative regulation of signal transduction;GO:0048484|enteric nervous system development;","GO:0005871|kinesin complex;GO:0005874|microtubule;","GO:0003777|microtubule motor activity;GO:0005524|ATP binding;GO:0008017|microtubule binding;","K10404","KIF26; kinesin family member 26"]
["ENSRNOG00000003601",2,0.128660876,64,4.131959018,0.031137985,-5.005180619,{"v":1.56411E-16,"d":"1.56E-16"},{"v":2.23216e-16,"d":"2.23E-16"},"down","yes","RGD1564463","protein_coding","chr13:92831537-92839246:+","gi|34881169|ref|XP_223005.2|",1730,0,"PREDICTED: sphingolipid delta(4)-desaturase DES1 [Rattus norvegicus]","gi|672027459|ref|XM_001062653.3|",1512,0,"PREDICTED: Rattus norvegicus similar to Mdes protein (RGD1564463), mRNA","O09005",527,0,"Sphingolipid delta(4)-desaturase DES1",".",".",".",".","pfam00487","FA_desaturase","Fatty acid desaturase.","GO:0046513|ceramide biosynthetic process;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0031966|mitochondrial membrane;","GO:0042284|sphingolipid delta-4 desaturase activity;GO:0050251|retinol isomerase activity;","K04712","DEGS; sphingolipid 4-desaturase/C4-monooxygenase [EC:1.14.19.17 1.14.18.5]"]
["ENSRNOG00000005530",161,10.35720055,343,22.14471786,0.467705238,-1.096328507,{"v":1.76143e-16,"d":"1.76E-16"},{"v":2.50874e-16,"d":"2.51E-16"},"down","yes","Rps6kl1","protein_coding","chr6:104783258-104799869:-","gi|564307559|ref|XP_006225915.1|",2662,0,"PREDICTED: ribosomal protein S6 kinase-like 1 isoform X1 [Rattus norvegicus]","gi|672020977|ref|XM_006225853.2|",2454,0,"PREDICTED: Rattus norvegicus ribosomal protein S6 kinase-like 1 (Rps6kl1), transcript variant X1, mRNA","Q8R2S1",932,0,"Ribosomal protein S6 kinase-like 1",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006468|protein phosphorylation;",".","GO:0005524|ATP binding;","K20839","RSKL; ribosomal protein S6 kinase-like"]
["ENSRNOG00000008554",100,6.433043818,251,16.20502677,0.39697829,-1.332867984,{"v":1.98842E-16,"d":"1.99E-16"},{"v":2.82569e-16,"d":"2.83E-16"},"down","yes","Slc9a9","protein_coding","chr8:95232905-95796318:+","gi|406719604|ref|NP_001258367.1|",3032,0,"sodium/hydrogen exchanger 9 [Rattus norvegicus]","gi|406719603|ref|NM_001271438.1|",3473,0,"Rattus norvegicus solute carrier family 9 member A9 (Slc9a9), mRNA","Q8BZ00",1152,0,"Sodium/hydrogen exchanger 9","YDR456w",239,{"v":3e-66,"d":"3.00E-66"},"COG0025","pfam00999","Na_H_Exchanger","Sodium/hydrogen exchanger family. Na/H antiporters are key transporters in maintaining the pH of actively metabolizing cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.","GO:0051453|regulation of intracellular pH;GO:0071805|potassium ion transmembrane transport;GO:0098656|anion transmembrane transport;GO:0098719|sodium ion import across plasma membrane;GO:1902600|proton transmembrane transport;","GO:0005886|plasma membrane;GO:0010008|endosome membrane;GO:0016021|integral component of membrane;GO:0055037|recycling endosome;","GO:0015385|sodium:proton antiporter activity;GO:0015386|potassium:proton antiporter activity;","K14725","SLC9A9, NHE9; solute carrier family 9 (sodium/hydrogen exchanger), member 9"]
["ENSRNOG00000028077",4,0.257321753,69,4.454768316,0.057763218,-4.113705076,{"v":2.06751E-16,"d":"2.07E-16"},{"v":2.93736E-16,"d":"2.94E-16"},"down","yes","Cfap44","protein_coding","chr11:56201049-56283986:-","gi|672071361|ref|XP_008767007.1|",8288,0,"PREDICTED: WD repeat-containing protein 52 isoform X2 [Rattus norvegicus]","gi|672071360|ref|XM_008768785.1|",5863,0,"PREDICTED: Rattus norvegicus cilia and flagella associated protein 44 (Cfap44), transcript variant X2, mRNA","Q96MT7",1310,0,"Cilia- and flagella-associated protein 44",".",".",".",".","pfam10174","Cast","RIM-binding protein of the cytomatrix active zone. This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.","GO:0000226|microtubule cytoskeleton organization;GO:0006508|proteolysis;GO:0007288|sperm axoneme assembly;GO:0030317|flagellated sperm motility;GO:0060271|cilium assembly;GO:0060285|cilium-dependent cell motility;",".","GO:0008233|peptidase activity;","K24224","CFAP44, WDR52; cilia- and flagella-associated protein 44"]
["ENSRNOG00000061845",146,9.392243975,320,20.65979509,0.454614576,-1.137284155,{"v":2.50217E-16,"d":"2.50E-16"},{"v":3.54607e-16,"d":"3.55E-16"},"down","yes","Cttnbp2","protein_coding","chr4:46800981-46964631:-","gi|167555091|ref|NP_001107873.1|",7995,0,"cortactin-binding protein 2 [Rattus norvegicus]","gi|167555090|ref|NM_001114401.1|",5935,0,"Rattus norvegicus cortactin binding protein 2 (Cttnbp2), mRNA","Q2IBD4",3057,0,"Cortactin-binding protein 2","all2748",98.6,{"v":2e-20,"d":"2.00E-20"},"COG0666","pfam09727","CortBP2","Cortactin-binding protein-2. This entry is the first approximately 250 residues of cortactin-binding protein 2. In addition to being a positional candidate for autism this protein is expressed at highest levels in the brain in humans. The human protein has six associated ankyrin repeat domains pfam00023 towards the C-terminus which act as protein-protein interaction domains.","GO:0007420|brain development;GO:0050807|regulation of synapse organization;GO:1905274|regulation of modification of postsynaptic actin cytoskeleton;","GO:0005938|cell cortex;GO:0008021|synaptic vesicle;GO:0043197|dendritic spine;GO:0098871|postsynaptic actin cytoskeleton;GO:0098978|glutamatergic synapse;","GO:0017124|SH3 domain binding;",".","."]
["ENSRNOG00000020505",178,11.450818,366,23.62964063,0.48459552,-1.045147027,{"v":2.74513E-16,"d":"2.75E-16"},{"v":3.88557e-16,"d":"3.89E-16"},"down","yes","Map4k1","protein_coding","chr1:84271069-84292493:+","gi|157819825|ref|NP_001099713.1|",3674,0,"mitogen-activated protein kinase kinase kinase kinase 1 [Rattus norvegicus]","gi|157819824|ref|NM_001106243.1|",2699,0,"Rattus norvegicus mitogen activated protein kinase kinase kinase kinase 1 (Map4k1), mRNA","P70218",1360,0,"Mitogen-activated protein kinase kinase kinase kinase 1",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006468|protein phosphorylation;GO:0007254|JNK cascade;GO:0008150|biological_process;GO:0008283|cell proliferation;GO:0018105|peptidyl-serine phosphorylation;GO:0035556|intracellular signal transduction;GO:0046777|protein autophosphorylation;GO:1904628|cellular response to phorbol 13-acetate 12-myristate;","GO:0005575|cellular_component;","GO:0003674|molecular_function;GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;GO:0008349|MAP kinase kinase kinase kinase activity;","K04408","MAP4K1, HPK1; mitogen-activated protein kinase kinase kinase kinase 1 [EC:2.7.11.1]"]
["ENSRNOG00000003284",3,0.192991315,65,4.196520878,0.045988408,-4.442585932,{"v":4.05746e-16,"d":"4.06E-16"},{"v":5.719e-16,"d":"5.72E-16"},"down","yes","Epn3","protein_coding","chr10:79438978-79447356:-","gi|564373961|ref|XP_006247263.1|",2612,0,"PREDICTED: epsin-3 isoform X2 [Rattus norvegicus]","gi|672068794|ref|XM_006247202.2|",3576,0,"PREDICTED: Rattus norvegicus epsin 3 (Epn3), transcript variant X2, mRNA","Q91W69",962,0,"Epsin-3",".",".",".",".","pfam01417","ENTH","ENTH domain. The ENTH (Epsin N-terminal homology) domain is found in proteins involved in endocytosis and cytoskeletal machinery. The function of the ENTH domain is unknown.","GO:0006897|endocytosis;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005768|endosome;GO:0005886|plasma membrane;GO:0005905|clathrin-coated pit;GO:0005938|cell cortex;GO:0019897|extrinsic component of plasma membrane;GO:0030125|clathrin vesicle coat;GO:0030136|clathrin-coated vesicle;GO:0043231|intracellular membrane-bounded organelle;GO:0048471|perinuclear region of cytoplasm;","GO:0005543|phospholipid binding;GO:0030276|clathrin binding;GO:1990175|EH domain binding;","K12471","EPN; epsin"]
["ENSRNOG00000001527",46,2.959200157,159,10.26533569,0.288271153,-1.794501619,{"v":4.15967e-16,"d":"4.16E-16"},{"v":5.85873e-16,"d":"5.86E-16"},"down","yes","Cd80","protein_coding","chr11:62254624-62292030:-","gi|2853281|gb|AAC02262.1|",1358,{"v":2E-176,"d":"2.00E-176"},"CD80 [Rattus norvegicus]","gi|672071070|ref|XM_006248365.2|",1385,0,"PREDICTED: Rattus norvegicus Cd80 molecule (Cd80), transcript variant X1, mRNA","Q00609",352,{"v":7e-111,"d":"7.00E-111"},"T-lymphocyte activation antigen CD80",".",".",".",".","pfam08205","C2-set_2","CD80-like C2-set immunoglobulin domain. These domains belong to the immunoglobulin superfamily.","GO:0006955|immune response;GO:0007166|cell surface receptor signaling pathway;GO:0031295|T cell costimulation;GO:0042102|positive regulation of T cell proliferation;GO:0042130|negative regulation of T cell proliferation;GO:0046641|positive regulation of alpha-beta T cell proliferation;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0071222|cellular response to lipopolysaccharide;","GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0098636|protein complex involved in cell adhesion;","GO:0003674|molecular_function;GO:0015026|coreceptor activity;","K05412","CD80; CD80 antigen"]
["ENSRNOG00000030689",45,2.894869718,157,10.13621197,0.285596802,-1.807948272,{"v":4.5064e-16,"d":"4.51E-16"},{"v":6.34084e-16,"d":"6.34E-16"},"down","yes","Ms4a6bl","protein_coding","chr1:208153530-208174479:+","gi|564298878|ref|XP_002725833.2|",1081,{"v":2e-141,"d":"2.00E-141"},"PREDICTED: membrane-spanning 4-domains subfamily A member 6C-like isoform X3 [Rattus norvegicus]","gi|672014682|ref|XM_006223653.2|",794,0,"PREDICTED: Rattus norvegicus membrane-spanning 4-domains, subfamily A, member 6C (Ms4a6c), transcript variant X4, mRNA","Q99N08",305,{"v":4e-98,"d":"4.00E-98"},"Membrane-spanning 4-domains subfamily A member 6C",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.",".","GO:0016021|integral component of membrane;",".","K22191","MS4A5_6_7; membrane-spanning 4-domains subfamily A member 5/6/7"]
["ENSRNOG00000036649",87,5.596748122,228,14.720104,0.380211181,-1.395127138,{"v":4.85667e-16,"d":"4.86E-16"},{"v":6.82529e-16,"d":"6.83E-16"},"down","yes","Pwwp2b","protein_coding","chr1:194041341-194059958:+","gi|564331527|ref|XP_006230528.1|",2634,0,"PREDICTED: PWWP domain-containing protein 2B isoform X1 [Rattus norvegicus]","gi|672038909|ref|XM_006230466.2|",2530,0,"PREDICTED: Rattus norvegicus PWWP domain containing 2B (Pwwp2b), transcript variant X1, mRNA","Q6NUJ5",707,0,"PWWP domain-containing protein 2B",".",".",".",".","pfam00855","PWWP","PWWP domain. The PWWP domain is named after a conserved Pro-Trp-Trp-Pro motif. The domain binds to Histone-4 methylated at lysine-20, H4K20me, suggesting that it is methyl-lysine recognition motif. Removal of two conserved aromatic residues in a hydrophobic cavity created by this domain within the full-length protein, Pdp1, abolishes the interaction o f the protein with H4K20me3. In fission yeast, Set9 is the sole enzyme that catalyses all three states of H4K20me, and Set9-mediated H4K20me is required for efficient recruitment of checkpoint protein Crb2 to sites of DNA damage. The methylation of H4K20 is involved in a diverse array of cellular processes, such as organizing higher-order chromatin, maintaining genome stability, and regulating cell-cycle progression.",".","GO:0005654|nucleoplasm;",".",".","."]
["ENSRNOG00000050968",28,1.801252269,124,8.005670597,0.22499705,-2.152022008,{"v":5.65114E-16,"d":"5.65E-16"},{"v":7.92035e-16,"d":"7.92E-16"},"down","yes","Ptger2","protein_coding","chr15:18217285-18228714:+","gi|13592031|ref|NP_112350.1|",1267,{"v":9E-170,"d":"9.00E-170"},"prostaglandin E2 receptor EP2 subtype [Rattus norvegicus]","gi|13592030|ref|NM_031088.1|",1323,0,"Rattus norvegicus prostaglandin E receptor 2 (subtype EP2) (Ptger2), mRNA","Q62928",492,{"v":3E-171,"d":"3.00E-171"},"Prostaglandin E2 receptor EP2 subtype",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001501|skeletal system development;GO:0006954|inflammatory response;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0032496|response to lipopolysaccharide;GO:0032570|response to progesterone;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0042127|regulation of cell proliferation;GO:0043066|negative regulation of apoptotic process;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0071380|cellular response to prostaglandin E stimulus;GO:1902219|negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress;GO:1904346|positive regulation of gastric mucosal blood circulation;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004957|prostaglandin E receptor activity;","K04259","PTGER2; prostaglandin E receptor 2"]
["ENSRNOG00000015986",166,10.67885274,346,22.33840344,0.478049059,-1.064769416,{"v":6.52187E-16,"d":"6.52E-16"},{"v":9.12057e-16,"d":"9.12E-16"},"down","yes","Rassf8","protein_coding","chr4:178719992-178796690:+","gi|300795738|ref|NP_001178682.1|",1665,0,"ras association domain-containing protein 8 [Rattus norvegicus]","gi|672051394|ref|XM_006237659.2|",3596,0,"PREDICTED: Rattus norvegicus Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 (Rassf8), transcript variant X3, mRNA","Q8CJ96",633,0,"Ras association domain-containing protein 8",".",".",".",".","pfam02841","GBP_C","Guanylate-binding protein, C-terminal domain. Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.","GO:0007165|signal transduction;",".",".","K09855","RASSF7_8; Ras association domain-containing protein 7/8"]
["ENSRNOG00000058586",138,8.87760047,305,19.69136719,0.450837181,-1.149321595,{"v":7.10894e-16,"d":"7.11E-16"},{"v":9.92698e-16,"d":"9.93E-16"},"down","yes","Tyro3","protein_coding","chr3:106777635-106797142:+","gi|149023034|gb|EDL79928.1|",4400,0,"TYRO3 protein tyrosine kinase 3 [Rattus norvegicus]","gi|8394495|ref|NM_017092.1|",3604,0,"Rattus norvegicus TYRO3 protein tyrosine kinase (Tyro3), mRNA","P55146",1657,0,"Tyrosine-protein kinase receptor TYRO3","YAR019c",94,{"v":2e-18,"d":"2.00E-18"},"COG0515","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001779|natural killer cell differentiation;GO:0006468|protein phosphorylation;GO:0006909|phagocytosis;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007218|neuropeptide signaling pathway;GO:0007275|multicellular organism development;GO:0007283|spermatogenesis;GO:0007399|nervous system development;GO:0016477|cell migration;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0021885|forebrain cell migration;GO:0030168|platelet activation;GO:0032940|secretion by cell;GO:0033674|positive regulation of kinase activity;GO:0034122|negative regulation of toll-like receptor signaling pathway;GO:0034446|substrate adhesion-dependent cell spreading;GO:0042698|ovulation cycle;GO:0043277|apoptotic cell clearance;GO:0043491|protein kinase B signaling;GO:0043524|negative regulation of neuron apoptotic process;GO:0045824|negative regulation of innate immune response;GO:0046718|viral entry into host cell;GO:0046777|protein autophosphorylation;GO:0050728|negative regulation of inflammatory response;GO:0051250|negative regulation of lymphocyte activation;GO:0060068|vagina development;GO:0070050|neuron cellular homeostasis;GO:0070527|platelet aggregation;GO:1903902|positive regulation of viral life cycle;","GO:0005634|nucleus;GO:0005635|nuclear envelope;GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0043235|receptor complex;","GO:0001618|virus receptor activity;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0005524|ATP binding;GO:0043548|phosphatidylinositol 3-kinase binding;","K05116","TYRO3, RSE; TYRO3 protein tyrosine kinase 3 [EC:2.7.10.1]"]
["ENSRNOG00000027855",3,0.192991315,64,4.131959018,0.046706977,-4.420218119,{"v":7.35075e-16,"d":"7.35E-16"},{"v":1.02571e-15,"d":"1.03E-15"},"down","yes","ENSRNOG00000027855","protein_coding","chr1:69616601-69660558:-","gi|625288029|ref|XP_007635741.1|",2046,0,"PREDICTED: LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily B member 3 isoform X2 [Cricetulus griseus]","gi|17105353|ref|NM_057199.1|",1042,0,"Rattus norvegicus natural cytotoxicity triggering receptor 1 (Ncr1), mRNA","Q9Z0H5",654,0,"Natural cytotoxicity triggering receptor 1",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0002446|neutrophil mediated immunity;GO:0033031|positive regulation of neutrophil apoptotic process;GO:0035457|cellular response to interferon-alpha;GO:0038093|Fc receptor signaling pathway;GO:0042119|neutrophil activation;GO:0071222|cellular response to lipopolysaccharide;GO:0071346|cellular response to interferon-gamma;GO:0071354|cellular response to interleukin-6;GO:0071356|cellular response to tumor necrosis factor;GO:0097011|cellular response to granulocyte macrophage colony-stimulating factor stimulus;GO:1903209|positive regulation of oxidative stress-induced cell death;","GO:0005886|plasma membrane;","GO:0019766|IgA receptor activity;GO:0019862|IgA binding;","K06513","FCAR, CD89; CD89 antigen"]
["ENSRNOG00000064855",23,1.479600078,113,7.295490141,0.202810236,-2.301797626,{"v":7.9302e-16,"d":"7.93E-16"},{"v":1.10576E-15,"d":"1.11E-15"},"down","yes","ENSRNOG00000064855","lncRNA","chr2:183842051-183844322:+","gi|149030597|gb|EDL85634.1|",176,{"v":2E-12,"d":"2.00E-12"},"rCG52010, isoform CRA_a [Rattus norvegicus]","gi|51262144|gb|BC079138.1|",250,{"v":3e-126,"d":"3.00E-126"},"Rattus norvegicus cDNA clone IMAGE:7127764",".",".",".",".",".",".",".",".","pfam09863","DUF2090","Uncharacterized protein conserved in bacteria (DUF2090). This domain, found in various prokaryotic carbohydrate kinases, has no known function.",".",".",".",".","."]
["ENSRNOG00000022239",35,2.251565336,137,8.844974773,0.254558706,-1.973929685,{"v":8.2235e-16,"d":"8.22E-16"},{"v":1.14553e-15,"d":"1.15E-15"},"down","yes","Trarg1","protein_coding","chr10:61521107-61541494:+","gi|149053450|gb|EDM05267.1|",623,{"v":3e-72,"d":"3.00E-72"},"rCG32530 [Rattus norvegicus]","gi|85662384|ref|NM_001039163.1|",3330,0,"Rattus norvegicus tumor suppressor candidate 5 (Tusc5), mRNA","Q2MHH0",219,{"v":7e-64,"d":"7.00E-64"},"Tumor suppressor candidate 5 homolog",".",".",".",".","pfam04505","Dispanin","Interferon-induced transmembrane protein. This family includes the human leukocyte antigen CD225, which is an interferon inducible transmembrane protein, and is associated with interferon induced cell growth suppression.","GO:0032869|cellular response to insulin stimulus;GO:0044381|glucose import in response to insulin stimulus;GO:0072659|protein localization to plasma membrane;GO:0099500|vesicle fusion to plasma membrane;GO:0099638|endosome to plasma membrane protein transport;","GO:0005886|plasma membrane;GO:0012505|endomembrane system;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030659|cytoplasmic vesicle membrane;GO:0048471|perinuclear region of cytoplasm;",".",".","."]
["ENSRNOG00000008600",51,3.280852347,166,10.7172687,0.306127656,-1.707794709,{"v":9.81834e-16,"d":"9.82E-16"},{"v":1.36205e-15,"d":"1.36E-15"},"down","yes","Sytl1","protein_coding","chr5:145422669-145462940:-","gi|71043698|ref|NP_001020822.1|",2400,0,"synaptotagmin-like protein 1 [Rattus norvegicus]","gi|71043697|ref|NM_001025651.1|",2035,0,"Rattus norvegicus synaptotagmin-like 1 (Sytl1), mRNA","Q99N80",786,0,"Synaptotagmin-like protein 1",".",".",".",".","pfam00168","C2","C2 domain.","GO:0006886|intracellular protein transport;GO:0006887|exocytosis;GO:0016192|vesicle-mediated transport;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0019897|extrinsic component of plasma membrane;GO:0042470|melanosome;GO:0070382|exocytic vesicle;","GO:0031267|small GTPase binding;GO:0042043|neurexin family protein binding;","K17598","SYTL; synaptotagmin-like protein"]
["ENSRNOG00000017939",65,4.181478482,190,12.26675333,0.34087899,-1.552668415,{"v":1.03644e-15,"d":"1.04E-15"},{"v":1.43675e-15,"d":"1.44E-15"},"down","yes","Chn1","protein_coding","chr3:58510536-58676490:-","gi|262205420|ref|NP_001106717.2|",2474,0,"N-chimaerin isoform 3 [Mus musculus]","gi|262205419|ref|NM_001113246.2|",2055,0,"Mus musculus chimerin 1 (Chn1), transcript variant 3, mRNA","Q91V57",957,0,"N-chimaerin",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0007165|signal transduction;GO:0008045|motor neuron axon guidance;GO:0035556|intracellular signal transduction;GO:0043087|regulation of GTPase activity;GO:0043547|positive regulation of GTPase activity;GO:0048013|ephrin receptor signaling pathway;GO:0050770|regulation of axonogenesis;GO:0051056|regulation of small GTPase mediated signal transduction;",".","GO:0001565|phorbol ester receptor activity;GO:0005096|GTPase activator activity;GO:0046872|metal ion binding;GO:0046875|ephrin receptor binding;","K20630","CHN1_2, ARHGAP2_3; chimaerin"]
["ENSRNOG00000070149",0,0.032165219,61,3.938273439,0.00816734,-6.935917957,{"v":1.36091e-15,"d":"1.36E-15"},{"v":1.8788e-15,"d":"1.88E-15"},"down","yes","Fut9","protein_coding","chr5:39351819-39565130:-","gi|16758212|ref|NP_445917.1|",1931,0,"alpha-(1,3)-fucosyltransferase 9 [Rattus norvegicus]","gi|84794634|ref|NM_010243.3|",2140,0,"Mus musculus fucosyltransferase 9 (Fut9), mRNA","Q99JB3",748,0,"Alpha-(1,3)-fucosyltransferase 9",".",".",".",".","pfam00852","Glyco_transf_10","Glycosyltransferase family 10 (fucosyltransferase). This family of Fucosyltransferases are the enzymes transferring fucose from GDP-Fucose to GlcNAc in an alpha1,3 linkage. This family is know as glycosyltransferase family 10.",".",".",".",".","."]
["ENSRNOG00000001506",12,0.771965258,87,5.61688179,0.137436622,-2.863161614,{"v":1.50097E-15,"d":"1.50E-15"},{"v":2.06765E-15,"d":"2.07E-15"},"down","yes","Tmem35a","protein_coding","chrX:97503350-97514197:+","gi|444518831|gb|ELV12416.1|",770,{"v":1e-92,"d":"1.00E-92"},"Transmembrane protein 35 [Tupaia chinensis]","gi|49169969|ref|NM_001001799.1|",1944,0,"Rattus norvegicus transmembrane protein 35 (Tmem35), mRNA","Q6JAM9",286,{"v":3e-91,"d":"3.00E-91"},"Transmembrane protein 35A",".",".",".",".","pfam13564","DoxX_2","DoxX-like family. This family of uncharacterized proteins are related to DoxX pfam07681.","GO:0051131|chaperone-mediated protein complex assembly;GO:2000010|positive regulation of protein localization to cell surface;","GO:0005778|peroxisomal membrane;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0031410|cytoplasmic vesicle;","GO:0030548|acetylcholine receptor regulator activity;",".","."]
["ENSRNOG00000016595",85,5.468087246,221,14.26817098,0.383236734,-1.383692243,{"v":2.02643e-15,"d":"2.03E-15"},{"v":2.77943e-15,"d":"2.78E-15"},"down","yes","Hhex","protein_coding","chr1:235190455-235196042:+","gi|13242291|ref|NP_077361.1|",948,{"v":1e-121,"d":"1.00E-121"},"hematopoietically-expressed homeobox protein HHEX [Rattus norvegicus]","gi|13242290|ref|NM_024385.1|",1590,0,"Rattus norvegicus hematopoietically expressed homeobox (Hhex), mRNA","P43120",361,{"v":4e-120,"d":"4.00E-120"},"Hematopoietically-expressed homeobox protein Hhex",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001570|vasculogenesis;GO:0001701|in utero embryonic development;GO:0001889|liver development;GO:0002009|morphogenesis of an epithelium;GO:0002573|myeloid leukocyte differentiation;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006406|mRNA export from nucleus;GO:0007165|signal transduction;GO:0007219|Notch signaling pathway;GO:0007492|endoderm development;GO:0009611|response to wounding;GO:0009887|animal organ morphogenesis;GO:0009952|anterior/posterior pattern specification;GO:0016525|negative regulation of angiogenesis;GO:0016973|poly(A)+ mRNA export from nucleus;GO:0022027|interkinetic nuclear migration;GO:0030097|hemopoiesis;GO:0030154|cell differentiation;GO:0030177|positive regulation of Wnt signaling pathway;GO:0030183|B cell differentiation;GO:0030878|thyroid gland development;GO:0030900|forebrain development;GO:0030948|negative regulation of vascular endothelial growth factor receptor signaling pathway;GO:0031016|pancreas development;GO:0034504|protein localization to nucleus;GO:0035050|embryonic heart tube development;GO:0035264|multicellular organism growth;GO:0042127|regulation of cell proliferation;GO:0043434|response to peptide hormone;GO:0045736|negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048568|embryonic organ development;GO:0048729|tissue morphogenesis;GO:0048853|forebrain morphogenesis;GO:0060431|primary lung bud formation;GO:0061009|common bile duct development;GO:0061010|gall bladder development;GO:0061011|hepatic duct development;GO:0061017|hepatoblast differentiation;GO:0070365|hepatocyte differentiation;GO:0070663|regulation of leukocyte proliferation;GO:0071103|DNA conformation change;GO:0090009|primitive streak formation;GO:0090263|positive regulation of canonical Wnt signaling pathway;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0032993|protein-DNA complex;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003682|chromatin binding;GO:0003700|DNA-binding transcription factor activity;GO:0008190|eukaryotic initiation factor 4E binding;GO:0008301|DNA binding, bending;GO:0042803|protein homodimerization activity;GO:0043565|sequence-specific DNA binding;GO:0071837|HMG box domain binding;","K08024","HHEX, HEX, PRH; homeobox protein HEX"]
["ENSRNOG00000014650",23,1.479600078,111,7.166366422,0.206464475,-2.27603453,{"v":2.19795e-15,"d":"2.20E-15"},{"v":3.01035e-15,"d":"3.01E-15"},"down","yes","Sema4g","protein_coding","chr1:243853854-243865341:+","gi|209862780|ref|NP_001101996.1|",3831,0,"semaphorin-4G precursor [Rattus norvegicus]","gi|672040488|ref|XM_006231528.2|",4326,0,"PREDICTED: Rattus norvegicus sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G (Sema4g), transcript variant X1, mRNA","Q9WUH7",1436,0,"Semaphorin-4G",".",".",".",".","pfam01403","Sema","Sema domain. The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and human plexin A-3.","GO:0001755|neural crest cell migration;GO:0007411|axon guidance;GO:0030335|positive regulation of cell migration;GO:0048843|negative regulation of axon extension involved in axon guidance;GO:0050919|negative chemotaxis;GO:0071526|semaphorin-plexin signaling pathway;","GO:0005615|extracellular space;GO:0005887|integral component of plasma membrane;","GO:0030215|semaphorin receptor binding;GO:0045499|chemorepellent activity;","K06521","SEMA4, CD100; semaphorin 4"]
["ENSRNOG00000021067",18,1.157947887,100,6.456185966,0.179354791,-2.479111808,{"v":2.4817e-15,"d":"2.48E-15"},{"v":3.3868e-15,"d":"3.39E-15"},"down","yes","Fxyd7","protein_coding","chr1:86277678-86286954:-","gi|149056255|gb|EDM07686.1|",401,{"v":1E-46,"d":"1.00E-46"},"FXYD domain-containing ion transport regulator 7 [Rattus norvegicus]","gi|672035858|ref|XM_006228843.2|",448,0,"PREDICTED: Rattus norvegicus FXYD domain-containing ion transport regulator 7 (Fxyd7), transcript variant X1, mRNA","P59648",95.5,{"v":1e-23,"d":"1.00E-23"},"FXYD domain-containing ion transport regulator 7",".",".",".",".","pfam02038","ATP1G1_PLM_MAT8","ATP1G1/PLM/MAT8 family.","GO:0006811|ion transport;GO:0043269|regulation of ion transport;GO:2000649|regulation of sodium ion transmembrane transporter activity;","GO:0016021|integral component of membrane;","GO:0017080|sodium channel regulator activity;GO:0051117|ATPase binding;","K13364","FXYD7; FXYD domain-containing ion transport regulator 7"]
["ENSRNOG00000020884",12,0.771965258,86,5.55231993,0.139034722,-2.846482873,{"v":2.62588E-15,"d":"2.63E-15"},{"v":3.57928e-15,"d":"3.58E-15"},"down","yes","Cd6","protein_coding","chr1:207442877-207481634:-","gi|58477106|gb|AAH89767.1|",2923,0,"Cd6 protein [Rattus norvegicus]","gi|58477105|gb|BC089767.1|",3426,0,"Rattus norvegicus Cd6 molecule, mRNA (cDNA clone MGC:108551 IMAGE:7383438), complete cds","Q61003",933,0,"T-cell differentiation antigen CD6",".",".",".",".","pfam00530","SRCR","Scavenger receptor cysteine-rich domain. These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.","GO:0001771|immunological synapse formation;GO:0001934|positive regulation of protein phosphorylation;GO:0002438|acute inflammatory response to antigenic stimulus;GO:0006897|endocytosis;GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0032496|response to lipopolysaccharide;GO:0042102|positive regulation of T cell proliferation;GO:1900017|positive regulation of cytokine production involved in inflammatory response;","GO:0001772|immunological synapse;GO:0009897|external side of plasma membrane;GO:0031226|intrinsic component of plasma membrane;GO:0044214|spanning component of plasma membrane;","GO:0001530|lipopolysaccharide binding;GO:0005044|scavenger receptor activity;GO:0005515|protein binding;GO:0019901|protein kinase binding;GO:0042802|identical protein binding;GO:0070891|lipoteichoic acid binding;","K06456","CD6; T-cell surface glycoprotein CD6"]
["ENSRNOG00000015113",43,2.766208842,149,9.619717089,0.287556153,-1.798084385,{"v":3.15269E-15,"d":"3.15E-15"},{"v":4.28612e-15,"d":"4.29E-15"},"down","yes","Mocos","protein_coding","chr18:15931654-15977187:+","gi|564392795|ref|XP_006254528.1|",4653,0,"PREDICTED: molybdenum cofactor sulfurase isoform X1 [Rattus norvegicus]","gi|672082732|ref|XM_006254466.2|",3105,0,"PREDICTED: Rattus norvegicus molybdenum cofactor sulfurase (Mocos), transcript variant X1, mRNA","Q14CH1",1653,0,"Molybdenum cofactor sulfurase","MA1950",254,{"v":6e-73,"d":"6.00E-73"},"COG0520","pfam00266","Aminotran_5","Aminotransferase class-V. This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.","GO:0006777|Mo-molybdopterin cofactor biosynthetic process;GO:0043545|molybdopterin cofactor metabolic process;",".","GO:0008265|Mo-molybdopterin cofactor sulfurase activity;GO:0016829|lyase activity;GO:0030151|molybdenum ion binding;GO:0030170|pyridoxal phosphate binding;GO:0102867|molybdenum cofactor sulfurtransferase activity;","K15631","ABA3; molybdenum cofactor sulfurtransferase [EC:2.8.1.9]"]
["ENSRNOG00000058434",22,1.41526964,108,6.972680843,0.202973529,-2.300636503,{"v":3.47199e-15,"d":"3.47E-15"},{"v":4.7146e-15,"d":"4.71E-15"},"down","yes","Cfap99","protein_coding","chr14:76410555-76468125:-","gi|672028054|ref|XP_008764562.1|",3190,0,"PREDICTED: cilia and flagella associated protein 99 isoform X1 [Rattus norvegicus]","gi|672028053|ref|XM_008766340.1|",2725,0,"PREDICTED: Rattus norvegicus similar to CG14998-PC, isoform C (RGD1564567), transcript variant X1, mRNA","D6REC4",441,{"v":3e-142,"d":"3.00E-142"},"Cilia- and flagella-associated protein 99",".",".",".",".","pfam13868","Trichoplein","tumor suppressor, Mitostatin. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs).",".",".",".","K25608","CFAP99; cilia- and flagella-associated protein 99"]
["ENSRNOG00000019770",5,0.321652191,67,4.325644597,0.074359366,-3.749341715,{"v":3.78362e-15,"d":"3.78E-15"},{"v":5.13166e-15,"d":"5.13E-15"},"down","yes","Bnc1","protein_coding","chr1:135917687-135943333:-","gi|157821307|ref|NP_001102386.1|",4685,0,"zinc finger protein basonuclin-1 [Rattus norvegicus]","gi|157821306|ref|NM_001108916.1|",4722,0,"Rattus norvegicus basonuclin 1 (Bnc1), mRNA","O35914",1702,0,"Zinc finger protein basonuclin-1",".",".",".",".","pfam13894","zf-C2H2_4","C2H2-type zinc finger. This family contains a number of divergent C2H2 type zinc fingers.","GO:0006355|regulation of transcription, DNA-templated;GO:0006356|regulation of transcription by RNA polymerase I;GO:0006357|regulation of transcription by RNA polymerase II;GO:0042060|wound healing;GO:0045943|positive regulation of transcription by RNA polymerase I;GO:0050679|positive regulation of epithelial cell proliferation;GO:0051276|chromosome organization;GO:1900195|positive regulation of oocyte maturation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0043231|intracellular membrane-bounded organelle;","GO:0000182|rDNA binding;GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0001216|bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding;","K24146","BNC; zinc finger protein basonuclin"]
["ENSRNOG00000010665",30,1.929913146,124,8.005670597,0.241068268,-2.052486334,{"v":3.95098e-15,"d":"3.95E-15"},{"v":5.35483e-15,"d":"5.35E-15"},"down","yes","Ccr7","protein_coding","chr10:84097381-84108309:-","gi|41054914|ref|NP_955783.1|",1823,0,"C-C chemokine receptor type 7 precursor [Rattus norvegicus]","gi|58477680|gb|BC089762.1|",1936,0,"Rattus norvegicus chemokine (C-C motif) receptor 7, mRNA (cDNA clone MGC:108519 IMAGE:7381637), complete cds","P47774",674,0,"C-C chemokine receptor type 7",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0002408|myeloid dendritic cell chemotaxis;GO:0002606|positive regulation of dendritic cell antigen processing and presentation;GO:0002885|positive regulation of hypersensitivity;GO:0002922|positive regulation of humoral immune response;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0019722|calcium-mediated signaling;GO:0032496|response to lipopolysaccharide;GO:0032649|regulation of interferon-gamma production;GO:0032651|regulation of interleukin-1 beta production;GO:0032695|negative regulation of interleukin-12 production;GO:0032735|positive regulation of interleukin-12 production;GO:0038115|chemokine (C-C motif) ligand 19 signaling pathway;GO:0038116|chemokine (C-C motif) ligand 21 signaling pathway;GO:0045060|negative thymic T cell selection;GO:0048872|homeostasis of number of cells;GO:0050862|positive regulation of T cell receptor signaling pathway;GO:0060326|cell chemotaxis;GO:0071345|cellular response to cytokine stimulus;GO:0090023|positive regulation of neutrophil chemotaxis;GO:0097029|mature conventional dendritic cell differentiation;GO:2000510|positive regulation of dendritic cell chemotaxis;GO:2000522|positive regulation of immunological synapse formation;GO:2000525|positive regulation of T cell costimulation;GO:2000526|positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation;","GO:0005739|mitochondrion;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0016493|C-C chemokine receptor activity;GO:0019957|C-C chemokine binding;GO:0035757|chemokine (C-C motif) ligand 19 binding;GO:0035758|chemokine (C-C motif) ligand 21 binding;GO:0038117|C-C motif chemokine 19 receptor activity;GO:0038121|C-C motif chemokine 21 receptor activity;","K04182","CCR7, CD197; C-C chemokine receptor type 7"]
["ENSRNOG00000020828",114,7.333669953,264,17.04433095,0.430270333,-1.216684725,{"v":4.01373e-15,"d":"4.01E-15"},{"v":5.4373e-15,"d":"5.44E-15"},"down","yes","Pde4a","protein_coding","chr8:19703290-19751961:+","gi|149020512|gb|EDL78317.1|",3349,0,"phosphodiesterase 4A, cAMP specific, isoform CRA_b [Rattus norvegicus]","gi|158518443|ref|NM_013101.3|",2294,0,"Rattus norvegicus phosphodiesterase 4A (Pde4a), mRNA","P54748",1290,0,"cAMP-specific 3',5'-cyclic phosphodiesterase 4A",".",".",".",".","pfam00233","PDEase_I","3'5'-cyclic nucleotide phosphodiesterase.","GO:0006198|cAMP catabolic process;GO:0007165|signal transduction;GO:0007608|sensory perception of smell;GO:0009410|response to xenobiotic stimulus;GO:0010738|regulation of protein kinase A signaling;GO:0043949|regulation of cAMP-mediated signaling;GO:0050804|modulation of chemical synaptic transmission;GO:0071466|cellular response to xenobiotic stimulus;GO:0106070|regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0048471|perinuclear region of cytoplasm;GO:0098685|Schaffer collateral - CA1 synapse;","GO:0004114|3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0004115|3',5'-cyclic-AMP phosphodiesterase activity;GO:0005515|protein binding;GO:0030552|cAMP binding;GO:0046872|metal ion binding;","K13293","PDE4; cAMP-specific phosphodiesterase 4 [EC:3.1.4.53]"]
["ENSRNOG00000020970",57,3.666834977,173,11.16920172,0.328298751,-1.606918833,{"v":4.2106e-15,"d":"4.21E-15"},{"v":5.70128e-15,"d":"5.70E-15"},"down","yes","Rundc3a","protein_coding","chr10:87352646-87361765:+","gi|168823439|ref|NP_942053.2|",2160,0,"RUN domain-containing protein 3A [Rattus norvegicus]","gi|168823438|ref|NM_198758.2|",2050,0,"Rattus norvegicus RUN domain containing 3A (Rundc3a), mRNA","O08576",824,0,"RUN domain-containing protein 3A",".",".",".",".","pfam02759","RUN","RUN domain. This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.","GO:0010753|positive regulation of cGMP-mediated signaling;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0043231|intracellular membrane-bounded organelle;",".","K24787","RUNDC3; RUN domain-containing protein 3"]
["ENSRNOG00000014202",65,4.181478482,186,12.0085059,0.348209721,-1.521971617,{"v":5.19336e-15,"d":"5.19E-15"},{"v":7.00375e-15,"d":"7.00E-15"},"down","yes","Snx20","protein_coding","chr19:18435935-18445107:+","gi|672084453|ref|XP_008770624.1|",1456,0,"PREDICTED: sorting nexin-20 isoform X1 [Rattus norvegicus]","gi|68163432|ref|NM_001024999.1|",1368,0,"Rattus norvegicus sorting nexin 20 (Snx20), mRNA","Q5BK61",556,0,"Sorting nexin-20",".",".",".",".","pfam00787","PX","PX domain. PX domains bind to phosphoinositides.","GO:0015031|protein transport;","GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0031901|early endosome membrane;","GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0032266|phosphatidylinositol-3-phosphate binding;GO:1901981|phosphatidylinositol phosphate binding;","K17931","SNX20; sorting nexin-20"]
["ENSRNOG00000026435",35,2.251565336,133,8.586727334,0.262214607,-1.931180038,{"v":5.35252e-15,"d":"5.35E-15"},{"v":7.21329e-15,"d":"7.21E-15"},"down","yes","Arid3a","protein_coding","chr7:9755294-9780599:-","gi|224591422|ref|NP_001101536.2|",2361,0,"AT-rich interactive domain-containing protein 3A [Rattus norvegicus]","gi|224591421|ref|NM_001108066.2|",2362,0,"Rattus norvegicus AT-rich interaction domain 3A (Arid3a), mRNA","Q62431",835,0,"AT-rich interactive domain-containing protein 3A",".",".",".",".","pfam01388","ARID","ARID/BRIGHT DNA binding domain. This domain is know as ARID for AT-Rich Interaction Domain, and also known as the BRIGHT domain.","GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0045121|membrane raft;","GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003712|transcription coregulator activity;GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000005008",41,2.637547966,144,9.29690779,0.283701638,-1.817553616,{"v":5.77234e-15,"d":"5.77E-15"},{"v":7.76075e-15,"d":"7.76E-15"},"down","yes","Angpt4","protein_coding","chr3:140420389-140453583:+","gi|157820699|ref|NP_001099996.1|",2339,0,"angiopoietin-4 precursor [Rattus norvegicus]","gi|157820698|ref|NM_001106526.1|",2329,0,"Rattus norvegicus angiopoietin 4 (Angpt4), mRNA","Q9WVH6",796,0,"Angiopoietin-4",".",".",".",".","pfam00147","Fibrinogen_C","Fibrinogen beta and gamma chains, C-terminal globular domain.","GO:0007165|signal transduction;GO:0007171|activation of transmembrane receptor protein tyrosine kinase activity;GO:0007219|Notch signaling pathway;GO:0008150|biological_process;GO:0010595|positive regulation of endothelial cell migration;GO:0016525|negative regulation of angiogenesis;GO:0043066|negative regulation of apoptotic process;GO:0043536|positive regulation of blood vessel endothelial cell migration;GO:0043537|negative regulation of blood vessel endothelial cell migration;GO:0045766|positive regulation of angiogenesis;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0071456|cellular response to hypoxia;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0062023|collagen-containing extracellular matrix;","GO:0003674|molecular_function;GO:0005102|signaling receptor binding;GO:0030297|transmembrane receptor protein tyrosine kinase activator activity;GO:0030971|receptor tyrosine kinase binding;","K05467","ANGPT4; angiopoietin 4"]
["ENSRNOG00000015727",32,2.058574022,127,8.199356176,0.251065325,-1.993865306,{"v":6.05875e-15,"d":"6.06E-15"},{"v":8.13624e-15,"d":"8.14E-15"},"down","yes","Loxl4","protein_coding","chr1:241397983-241416322:-","gi|157820271|ref|NP_001101062.1|",3776,0,"lysyl oxidase homolog 4 precursor [Rattus norvegicus]","gi|157820270|ref|NM_001107592.1|",3789,0,"Rattus norvegicus lysyl oxidase-like 4 (Loxl4), mRNA","Q924C6",1412,0,"Lysyl oxidase homolog 4",".",".",".",".","pfam01186","Lysyl_oxidase","Lysyl oxidase.","GO:0006897|endocytosis;GO:0018057|peptidyl-lysine oxidation;GO:0030199|collagen fibril organization;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0016020|membrane;GO:0043235|receptor complex;","GO:0004720|protein-lysine 6-oxidase activity;GO:0005044|scavenger receptor activity;GO:0005507|copper ion binding;","K00280","LOXL2_3_4; lysyl oxidase-like protein 2/3/4 [EC:1.4.3.-]"]
["ENSRNOG00000004275",17,1.093617449,96,6.197938527,0.17644858,-2.502680279,{"v":6.3674e-15,"d":"6.37E-15"},{"v":8.54068e-15,"d":"8.54E-15"},"down","yes","Egfl6","protein_coding","chrX:27884125-27942044:+","gi|672087357|ref|XP_008771393.1|",2660,0,"PREDICTED: epidermal growth factor-like protein 6 isoform X1 [Rattus norvegicus]","gi|672087356|ref|XM_008773171.1|",2582,0,"PREDICTED: Rattus norvegicus EGF-like-domain, multiple 6 (Egfl6), transcript variant X1, mRNA","Q9JJZ5",945,0,"Epidermal growth factor-like protein 6",".",".",".",".","pfam00629","MAM","MAM domain. An extracellular domain found in many receptors.","GO:0007155|cell adhesion;GO:0010811|positive regulation of cell-substrate adhesion;GO:0030198|extracellular matrix organization;","GO:0005604|basement membrane;GO:0016020|membrane;GO:0031012|extracellular matrix;","GO:0005178|integrin binding;GO:0005509|calcium ion binding;","K25527","EGFL6, MAEG; epidermal growth factor-like protein 6"]
["ENSRNOG00000026679",29,1.865582707,121,7.811985018,0.238810328,-2.066062862,{"v":6.50072e-15,"d":"6.50E-15"},{"v":8.7154e-15,"d":"8.72E-15"},"down","yes","Scn4b","protein_coding","chr8:45446215-45462292:+","gi|57114338|ref|NP_001008880.1|",856,{"v":5e-101,"d":"5.00E-101"},"sodium channel subunit beta-4 precursor [Rattus norvegicus]","gi|57114337|ref|NM_001008880.1|",4192,0,"Rattus norvegicus sodium voltage-gated channel beta subunit 4 (Scn4b), mRNA","Q7M730",334,{"v":2e-102,"d":"2.00E-102"},"Sodium channel subunit beta-4",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0006814|sodium ion transport;GO:0008150|biological_process;GO:0010765|positive regulation of sodium ion transport;GO:0035725|sodium ion transmembrane transport;GO:0060048|cardiac muscle contraction;GO:0060307|regulation of ventricular cardiac muscle cell membrane repolarization;GO:0086002|cardiac muscle cell action potential involved in contraction;GO:0086012|membrane depolarization during cardiac muscle cell action potential;GO:0086016|AV node cell action potential;GO:0086091|regulation of heart rate by cardiac conduction;GO:2000649|regulation of sodium ion transmembrane transporter activity;","GO:0001518|voltage-gated sodium channel complex;GO:0005886|plasma membrane;GO:0014704|intercalated disc;GO:0031226|intrinsic component of plasma membrane;","GO:0003674|molecular_function;GO:0005244|voltage-gated ion channel activity;GO:0005248|voltage-gated sodium channel activity;GO:0017080|sodium channel regulator activity;GO:0044325|ion channel binding;GO:0086006|voltage-gated sodium channel activity involved in cardiac muscle cell action potential;","K04848","SCN4B; voltage-gated sodium channel type IV beta"]
["ENSRNOG00000026309",19,1.222278326,100,6.456185966,0.189318947,-2.401109296,{"v":7.85889e-15,"d":"7.86E-15"},{"v":1.04895E-14,"d":"1.05E-14"},"down","yes","Lrrc23","protein_coding","chr4:157581291-157591860:-","gi|564348949|ref|XP_006237422.1|",1184,{"v":6e-156,"d":"6.00E-156"},"PREDICTED: leucine-rich repeat-containing protein 23 isoform X2 [Rattus norvegicus]","gi|672051038|ref|XM_006237360.2|",1413,0,"PREDICTED: Rattus norvegicus leucine rich repeat containing 23 (Lrrc23), transcript variant X4, mRNA",".",".",".",".","CAC3274_2",81.3,{"v":1e-15,"d":"1.00E-15"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.",".","GO:0005829|cytosol;",".",".","."]
["ENSRNOG00000037339",12,0.771965258,84,5.423196211,0.142345073,-2.812535541,{"v":8.01278E-15,"d":"8.01E-15"},{"v":1.06899E-14,"d":"1.07E-14"},"down","yes","Siglec10","protein_coding","chr1:93817335-93825931:+","gi|564327834|ref|XP_006229010.1|",3455,0,"PREDICTED: sialic acid-binding Ig-like lectin 10 isoform X1 [Rattus norvegicus]","gi|672036310|ref|XM_006228948.2|",2498,0,"PREDICTED: Rattus norvegicus sialic acid binding Ig-like lectin 10 (Siglec10), transcript variant X1, mRNA","Q80ZE3",1113,0,"Sialic acid-binding Ig-like lectin 10",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0002244|hematopoietic progenitor cell differentiation;GO:0002638|negative regulation of immunoglobulin production;GO:0007155|cell adhesion;GO:0030888|regulation of B cell proliferation;GO:0050776|regulation of immune response;GO:0050849|negative regulation of calcium-mediated signaling;GO:0106015|negative regulation of inflammatory response to wounding;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0019902|phosphatase binding;GO:0030246|carbohydrate binding;GO:0033691|sialic acid binding;GO:0042169|SH2 domain binding;","K06749","SIGLEC10; sialic acid binding Ig-like lectin 10"]
["ENSRNOG00000062779",54,3.473843662,166,10.7172687,0.324135165,-1.625332549,{"v":9.08889e-15,"d":"9.09E-15"},{"v":1.20973E-14,"d":"1.21E-14"},"down","yes","ENSRNOG00000062779","protein_coding","chr12:17787127-17798094:+","gi|672033486|ref|XP_008756492.1|",1137,{"v":6E-152,"d":"6.00E-152"},"PREDICTED: paired immunoglobulin-like type 2 receptor alpha [Rattus norvegicus]","gi|672033485|ref|XM_008758270.1|",1159,0,"PREDICTED: Rattus norvegicus paired immunoglobin-like type 2 receptor alpha (Pilra), mRNA","Q2YFS3",327,{"v":6e-108,"d":"6.00E-108"},"Paired immunoglobulin-like type 2 receptor alpha",".",".",".",".","pfam14610","DUF4448","Protein of unknown function (DUF4448). This is a family of predicted membrane glycoproteins from fungi. However there appears, visually, to be some similarity with the family of GPI-anchored fungal proteins, pfam10342.",".",".",".",".","."]
["ENSRNOG00000018400",149,9.58523529,313,20.20786207,0.474331983,-1.076030946,{"v":9.16405e-15,"d":"9.16E-15"},{"v":1.21945E-14,"d":"1.22E-14"},"down","yes","Golm1","protein_coding","chr17:4996104-5034057:+","gi|564390269|ref|XP_006253608.1|",2416,0,"PREDICTED: Golgi membrane protein 1 isoform X2 [Rattus norvegicus]","gi|672081004|ref|XM_001056825.4|",3621,0,"PREDICTED: Rattus norvegicus golgi membrane protein 1 (Golm1), transcript variant X4, mRNA","Q91XA2",489,{"v":1e-158,"d":"1.00E-158"},"Golgi membrane protein 1",".",".",".",".","pfam05403","Plasmodium_HRP","Plasmodium histidine-rich protein (HRPII/III). This family consists of several histidine-rich protein II and III sequence from Plasmodium falciparum.","GO:0006997|nucleus organization;GO:0019216|regulation of lipid metabolic process;","GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000029179",16,1.029287011,93,6.004252948,0.171426324,-2.54433943,{"v":9.53713e-15,"d":"9.54E-15"},{"v":1.26732e-14,"d":"1.27E-14"},"down","yes","Cyp2d3","protein_coding","chr7:113908947-113922084:-","gi|23463315|ref|NP_695225.1|",1979,0,"cytochrome P450 2D1 [Rattus norvegicus]","gi|298911525|emb|FQ219613.1|",1277,0,"Rattus norvegicus TL0ABA44YB23 mRNA sequence","P10633",763,0,"Cytochrome P450 2D1",".",".",".",".","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0001889|liver development;GO:0006082|organic acid metabolic process;GO:0006805|xenobiotic metabolic process;GO:0009410|response to xenobiotic stimulus;GO:0010033|response to organic substance;GO:0014070|response to organic cyclic compound;GO:0019369|arachidonic acid metabolic process;GO:0042178|xenobiotic catabolic process;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0004497|monooxygenase activity;GO:0005506|iron ion binding;GO:0008395|steroid hydroxylase activity;GO:0016712|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0020037|heme binding;GO:0070330|aromatase activity;","K07414","CYP2D; cytochrome P450 family 2 subfamily D [EC:1.14.14.1]"]
["ENSRNOG00000065670",0,0.032165219,57,3.680026,0.008740487,-6.838070634,{"v":9.64677e-15,"d":"9.65E-15"},{"v":1.28159e-14,"d":"1.28E-14"},"down","yes","ENSRNOG00000065670","protein_coding","chr11:81539887-81555299:+","gi|89258027|gb|ABD65265.1|",491,{"v":2e-59,"d":"2.00E-59"},"immunoglobulin lambda light chain [Rattus norvegicus]","gi|89258026|gb|DQ394091.1|",331,{"v":1e-171,"d":"1.00E-171"},"Rattus norvegicus clone LuMo47.3 immunoglobulin lambda light chain mRNA, partial cds","P01721",117,{"v":6e-32,"d":"6.00E-32"},"Immunoglobulin lambda variable 6-57",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000056947",29,1.865582707,120,7.747423159,0.240800414,-2.05409022,{"v":1.05366E-14,"d":"1.05E-14"},{"v":1.39688e-14,"d":"1.40E-14"},"down","yes","AABR07025272.1","protein_coding","chr16:27840998-27951324:-","gi|564324417|ref|XP_006227112.1|",8478,0,"PREDICTED: probable ATP-dependent RNA helicase DDX60 isoform X3 [Rattus norvegicus]","gi|672033286|ref|XM_006227050.2|",5363,0,"PREDICTED: Rattus norvegicus DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 (Ddx60), transcript variant X3, mRNA","Q8IY21",2542,0,"Probable ATP-dependent RNA helicase DDX60","SPAC694.02",460,{"v":4e-132,"d":"4.00E-132"},"COG4581","pfam00270","DEAD","DEAD/DEAH box helicase. Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolizm, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.",".",".",".",".","."]
["ENSRNOG00000011562",35,2.251565336,131,8.457603615,0.266217884,-1.909320604,{"v":1.35412E-14,"d":"1.35E-14"},{"v":1.78692e-14,"d":"1.79E-14"},"down","yes","Slitrk2","protein_coding","chrX:145246460-145271220:+","gi|157821187|ref|NP_001101057.1|",4104,0,"SLIT and NTRK-like protein 2 precursor [Rattus norvegicus]","gi|672088797|ref|XM_006257626.2|",7732,0,"PREDICTED: Rattus norvegicus SLIT and NTRK-like family, member 2 (Slitrk2), transcript variant X2, mRNA","Q810C0",1566,0,"SLIT and NTRK-like protein 2",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.","GO:0007409|axonogenesis;GO:0050807|regulation of synapse organization;GO:0051965|positive regulation of synapse assembly;GO:0099560|synaptic membrane adhesion;GO:1905606|regulation of presynapse assembly;","GO:0098978|glutamatergic synapse;GO:0098982|GABA-ergic synapse;GO:0099055|integral component of postsynaptic membrane;",".",".","."]
["ENSRNOG00000033173",100,6.433043818,239,15.43028446,0.416910254,-1.262191238,{"v":1.44886E-14,"d":"1.45E-14"},{"v":1.91018E-14,"d":"1.91E-14"},"down","yes","Fam71e2","protein_coding","chr1:69077207-69095316:+","gi|672035014|ref|XP_008757143.1|",4301,0,"PREDICTED: putative protein FAM71E2 isoform X1 [Rattus norvegicus]","gi|672035013|ref|XM_008758921.1|",3028,0,"PREDICTED: Rattus norvegicus family with sequence similarity 71, member E2 (Fam71e2), transcript variant X1, mRNA","Q8N5Q1",508,{"v":2E-159,"d":"2.00E-159"},"Protein FAM71E2",".",".",".",".","pfam12480","DUF3699","Protein of unknown function (DUF3699). This domain family is found in eukaryotes, and is approximately 80 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000028768",21,1.350939202,103,6.649871544,0.203152676,-2.299363724,{"v":1.52166E-14,"d":"1.52E-14"},{"v":2.00338e-14,"d":"2.00E-14"},"down","yes","Gbp4","protein_coding","chr2:231305244-231318879:+","gi|149026108|gb|EDL82351.1|",3190,0,"rCG28728, isoform CRA_a [Rattus norvegicus]","gi|765365471|ref|NM_001305261.1|",2560,0,"Rattus norvegicus guanylate binding protein 4 (Gbp4), mRNA","Q61107",1088,0,"Guanylate-binding protein 4",".",".",".",".","pfam02263","GBP","Guanylate-binding protein, N-terminal domain. Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.","GO:0035458|cellular response to interferon-beta;GO:0042832|defense response to protozoan;GO:0044406|adhesion of symbiont to host;GO:0050830|defense response to Gram-positive bacterium;GO:0071346|cellular response to interferon-gamma;","GO:0005634|nucleus;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0031410|cytoplasmic vesicle;GO:0048471|perinuclear region of cytoplasm;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;","K20899","GBP1_3_4_7; guanylate-binding protein 1/3/4/7"]
["ENSRNOG00000058133",86,5.532417684,217,14.00992355,0.394892782,-1.340467097,{"v":1.60252e-14,"d":"1.60E-14"},{"v":2.10596E-14,"d":"2.11E-14"},"down","yes","Ppm1n","protein_coding","chr1:78929351-78932685:-","gi|319009550|ref|NP_001099701.2|",1857,0,"probable protein phosphatase 1N [Rattus norvegicus]","gi|319009549|ref|NM_001106231.2|",1621,0,"Rattus norvegicus protein phosphatase, Mg2+/Mn2+ dependent, 1N (Ppm1n), mRNA","Q8BGL1",644,0,"Probable protein phosphatase 1N","SPCC1223.11",147,{"v":2e-38,"d":"2.00E-38"},"COG0631","pfam00481","PP2C","Protein phosphatase 2C. Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.","GO:0006470|protein dephosphorylation;GO:0043124|negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0090263|positive regulation of canonical Wnt signaling pathway;","GO:0005634|nucleus;GO:0005829|cytosol;","GO:0000287|magnesium ion binding;GO:0030145|manganese ion binding;","K19790","PPM1N; protein phosphatase 1N [EC:3.1.3.16]"]
["ENSRNOG00000008765",2,0.128660876,56,3.615464141,0.035586268,-4.812535541,{"v":1.6746e-14,"d":"1.67E-14"},{"v":2.19966e-14,"d":"2.20E-14"},"down","yes","Zfhx4","protein_coding","chr2:96224767-96408228:-","gi|564335900|ref|XP_006232224.1|",16178,0,"PREDICTED: zinc finger homeobox protein 4 isoform X1 [Rattus norvegicus]","gi|672041888|ref|XM_006232162.2|",13988,0,"PREDICTED: Rattus norvegicus zinc finger homeobox 4 (Zfhx4), transcript variant X1, mRNA","Q9JJN2",5783,0,"Zinc finger homeobox protein 4","ECU06g0500",51.6,5e-06,"COG5576","pfam00046","Homeobox","Homeobox domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0008270|zinc ion binding;","K09380","ZFHX4; zinc finger homeobox protein 4"]
["ENSRNOG00000010086",171,11.00050493,342,22.080156,0.498207754,-1.005180619,{"v":1.83773E-14,"d":"1.84E-14"},{"v":2.41006e-14,"d":"2.41E-14"},"down","yes","Plagl2","protein_coding","chr3:141695322-141708503:-","gi|157818071|ref|NP_001099998.1|",938,{"v":3e-115,"d":"3.00E-115"},"zinc finger protein PLAGL2 [Rattus norvegicus]","gi|157818070|ref|NM_001106528.1|",3502,0,"Rattus norvegicus PLAG1 like zinc finger 2 (Plagl2), mRNA","Q9UPG8",345,{"v":9e-105,"d":"9.00E-105"},"Zinc finger protein PLAGL2",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0006351|transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006629|lipid metabolic process;GO:0009791|post-embryonic development;GO:0034378|chylomicron assembly;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:2001244|positive regulation of intrinsic apoptotic signaling pathway;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0043565|sequence-specific DNA binding;GO:0046872|metal ion binding;",".","."]
["ENSRNOG00000014152",58,3.731165415,171,11.040078,0.337965494,-1.565052139,{"v":1.93263e-14,"d":"1.93E-14"},{"v":2.53278e-14,"d":"2.53E-14"},"down","yes","Kcnip3","protein_coding","chr3:114677030-114743556:-","gi|564342924|ref|XP_006235051.1|",1484,0,"PREDICTED: calsenilin isoform X1 [Rattus norvegicus]","gi|672046967|ref|XM_006234989.2|",2591,0,"PREDICTED: Rattus norvegicus Kv channel interacting protein 3, calsenilin (Kcnip3), transcript variant X1, mRNA","Q9JM47",386,{"v":3e-138,"d":"3.00E-138"},"Calsenilin","SPAC18B11.04",152,{"v":8E-41,"d":"8.00E-41"},"COG5126","pfam13499","EF-hand_7","EF-hand domain pair.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006886|intracellular protein transport;GO:0006915|apoptotic process;GO:0019233|sensory perception of pain;GO:0032026|response to magnesium ion;GO:0043523|regulation of neuron apoptotic process;GO:0048265|response to pain;GO:0048266|behavioral response to pain;GO:0071805|potassium ion transmembrane transport;GO:0072659|protein localization to plasma membrane;GO:1901379|regulation of potassium ion transmembrane transport;","GO:0005634|nucleus;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0008076|voltage-gated potassium channel complex;GO:0030424|axon;GO:0030425|dendrite;GO:0032993|protein-DNA complex;GO:0043679|axon terminus;","GO:0000287|magnesium ion binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001046|core promoter sequence-specific DNA binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0005244|voltage-gated ion channel activity;GO:0005267|potassium channel activity;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0008022|protein C-terminus binding;GO:0015459|potassium channel regulator activity;GO:0043565|sequence-specific DNA binding;GO:0044325|ion channel binding;GO:0048306|calcium-dependent protein binding;","K23855","KCNIP; Kv channel-interacting protein"]
["ENSRNOG00000024433",73,4.696121987,195,12.58956263,0.373017088,-1.422686374,{"v":2.60449E-14,"d":"2.60E-14"},{"v":3.39071e-14,"d":"3.39E-14"},"down","yes","Fbxl7","protein_coding","chr2:77140826-77509223:-","gi|37360118|dbj|BAC98037.1|",2610,0,"mKIAA0840 protein [Mus musculus]","gi|157818662|ref|NM_001108545.1|",3473,0,"Rattus norvegicus F-box and leucine-rich repeat protein 7 (Fbxl7), mRNA","Q5BJ29",962,0,"F-box/LRR-repeat protein 7",".",".",".",".","pfam12937","F-box-like","F-box-like. This is an F-box-like family.","GO:0000086|G2/M transition of mitotic cell cycle;GO:0000209|protein polyubiquitination;GO:0000278|mitotic cell cycle;GO:0016567|protein ubiquitination;GO:0031146|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;","GO:0005813|centrosome;GO:0019005|SCF ubiquitin ligase complex;",".","K10273","FBXL7; F-box and leucine-rich repeat protein 7"]
["ENSRNOG00000016879",87,5.596748122,217,14.00992355,0.399484559,-1.323788356,{"v":2.83871e-14,"d":"2.84E-14"},{"v":3.68975e-14,"d":"3.69E-14"},"down","yes","Ldlrad4","protein_coding","chr18:61521428-61843238:+","gi|405113059|ref|NP_001258294.1|",1565,0,"low-density lipoprotein receptor class A domain-containing protein 4 [Rattus norvegicus]","gi|405113058|ref|NM_001271365.1|",2006,0,"Rattus norvegicus low density lipoprotein receptor class A domain containing 4 (Ldlrad4), mRNA","Q8BWJ4",597,0,"Low-density lipoprotein receptor class A domain-containing protein 4",".",".",".",".","pfam00057","Ldl_recept_a","Low-density lipoprotein receptor domain class A.","GO:0010719|negative regulation of epithelial to mesenchymal transition;GO:0010991|negative regulation of SMAD protein complex assembly;GO:0030336|negative regulation of cell migration;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0060394|negative regulation of pathway-restricted SMAD protein phosphorylation;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;GO:0031901|early endosome membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0070412|R-SMAD binding;",".","."]
["ENSRNOG00000010412",1,0.064330438,53,3.421778562,0.018800293,-5.733101074,{"v":3.40924E-14,"d":"3.41E-14"},{"v":4.41624e-14,"d":"4.42E-14"},"down","yes","Ccdc180","protein_coding","chr5:60154910-60223522:+","gi|672052577|ref|XP_008761927.1|",3420,0,"PREDICTED: coiled-coil domain-containing protein 180 isoform X2 [Rattus norvegicus]","gi|672052576|ref|XM_008763705.1|",2861,0,"PREDICTED: Rattus norvegicus coiled-coil domain containing 180 (Ccdc180), transcript variant X2, mRNA","Q9P1Z9",868,0,"Coiled-coil domain-containing protein 180",".",".",".",".","pfam14643","DUF4455","Domain of unknown function (DUF4455). This domain family is found in bacteria and eukaryotes, and is approximately 480 amino acids in length. There are two completely conserved residues (W and P) that may be functionally important.",".",".",".",".","."]
["ENSRNOG00000021098",96,6.175722066,230,14.84922772,0.415895169,-1.26570817,{"v":3.9641e-14,"d":"3.96E-14"},{"v":5.11527e-14,"d":"5.12E-14"},"down","yes","Rasgrp2","protein_coding","chr1:203707481-203722993:+","gi|564332376|ref|XP_006230915.1|",2944,0,"PREDICTED: RAS guanyl-releasing protein 2 isoform X1 [Rattus norvegicus]","gi|131889011|ref|NM_001082977.1|",2173,0,"Rattus norvegicus RAS guanyl releasing protein 2 (calcium and DAG-regulated) (Rasgrp2), mRNA","P0C643",1134,0,"RAS guanyl-releasing protein 2",".",".",".",".","pfam00617","RasGEF","RasGEF domain. Guanine nucleotide exchange factor for Ras-like small GTPases.","GO:0007264|small GTPase mediated signal transduction;GO:0043547|positive regulation of GTPase activity;GO:0071277|cellular response to calcium ion;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0032587|ruffle membrane;GO:0043005|neuron projection;GO:0045202|synapse;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0005509|calcium ion binding;","K12361","RASGRP2; RAS guanyl-releasing protein 2"]
["ENSRNOG00000002057",126,8.105635211,274,17.68994955,0.458205672,-1.125932779,{"v":5.37817e-14,"d":"5.38E-14"},{"v":6.89946e-14,"d":"6.90E-14"},"down","yes","Slc10a6","protein_coding","chr14:6080717-6103037:+","gi|37591183|ref|NP_932166.1|",1743,0,"solute carrier family 10 member 6 [Rattus norvegicus]","gi|37591182|ref|NM_198049.1|",1110,0,"Rattus norvegicus solute carrier family 10 member 6 (Slc10a6), mRNA","Q70EX6",676,0,"Solute carrier family 10 member 6","BS_yocS",108,{"v":1e-24,"d":"1.00E-24"},"COG0385","pfam01758","SBF","Sodium Bile acid symporter family. This family consists of Na+/bile acid co-transporters. These transmembrane proteins function in the liver in the uptake of bile acids from portal blood plasma a process mediated by the co-transport of Na+. Also in the family is ARC3 from S. cerevisiae, a putative transmembrane protein involved in resistance to arsenic compounds.","GO:0006814|sodium ion transport;GO:0015721|bile acid and bile salt transport;GO:0043251|sodium-dependent organic anion transport;GO:0055085|transmembrane transport;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0008508|bile acid:sodium symporter activity;GO:0043250|sodium-dependent organic anion transmembrane transporter activity;","K14346","SLC10A6, SOAT; solute carrier family 10 (sodium/bile acid cotransporter), member 6"]
["ENSRNOG00000042628",2,0.128660876,54,3.486340421,0.036904278,-4.760068122,{"v":5.43266E-14,"d":"5.43E-14"},{"v":6.9678e-14,"d":"6.97E-14"},"down","yes","Tmem273","protein_coding","chr16:8049669-8081981:+","gi|149034139|gb|EDL88909.1|",490,{"v":1e-57,"d":"1.00E-57"},"similar to novel protein (predicted), isoform CRA_b [Rattus norvegicus]","gi|254692852|ref|NM_001134605.2|",1076,0,"Rattus norvegicus similar to novel protein (RGD1561145), mRNA",".",".",".",".",".",".",".",".","pfam14986","DUF4514","Domain of unknown function (DUF4514). This family of uncharacterized proteins are found in mammals.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000026065",1,0.064330438,52,3.357216702,0.019161837,-5.705620337,{"v":5.93254e-14,"d":"5.93E-14"},{"v":7.59359e-14,"d":"7.59E-14"},"down","yes","Slit1","protein_coding","chr1:240409561-240558127:-","gi|149040169|gb|EDL94207.1|",7301,0,"rCG57618, isoform CRA_a [Rattus norvegicus]","gi|158341667|ref|NM_022953.2|",3646,0,"Rattus norvegicus slit guidance ligand 1 (Slit1), mRNA","O88279",2798,0,"Slit homolog 1 protein","SPy1798",61.2,3e-08,"COG4886","pfam02210","Laminin_G_2","Laminin G domain. This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.","GO:0007097|nuclear migration;GO:0007399|nervous system development;GO:0007409|axonogenesis;GO:0007411|axon guidance;GO:0007420|brain development;GO:0008045|motor neuron axon guidance;GO:0021510|spinal cord development;GO:0021772|olfactory bulb development;GO:0022028|tangential migration from the subventricular zone to the olfactory bulb;GO:0022029|telencephalon cell migration;GO:0030154|cell differentiation;GO:0031290|retinal ganglion cell axon guidance;GO:0033563|dorsal/ventral axon guidance;GO:0048812|neuron projection morphogenesis;GO:0048843|negative regulation of axon extension involved in axon guidance;GO:0048846|axon extension involved in axon guidance;GO:0050919|negative chemotaxis;GO:0051964|negative regulation of synapse assembly;","GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0008201|heparin binding;GO:0043395|heparan sulfate proteoglycan binding;GO:0048495|Roundabout binding;","K06838","SLIT1; slit 1"]
["ENSRNOG00000013902",14,0.900626135,85,5.487758071,0.164115495,-2.607216633,{"v":6.12307e-14,"d":"6.12E-14"},{"v":7.82869e-14,"d":"7.83E-14"},"down","yes","P2ry12","protein_coding","chr2:143481430-143523361:-","gi|12248187|ref|NP_073637.1|",1689,0,"P2Y purinoceptor 12 [Rattus norvegicus]","gi|672042396|ref|XM_006232408.2|",2092,0,"PREDICTED: Rattus norvegicus purinergic receptor P2Y, G-protein coupled, 12 (P2ry12), transcript variant X3, mRNA","Q9EPX4",655,0,"P2Y purinoceptor 12",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001973|adenosine receptor signaling pathway;GO:0006930|substrate-dependent cell migration, cell extension;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007188|adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007193|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0008347|glial cell migration;GO:0010700|negative regulation of norepinephrine secretion;GO:0019722|calcium-mediated signaling;GO:0021808|cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration;GO:0030030|cell projection organization;GO:0030032|lamellipodium assembly;GO:0030168|platelet activation;GO:0033626|positive regulation of integrin activation by cell surface receptor linked signal transduction;GO:0033630|positive regulation of cell adhesion mediated by integrin;GO:0035585|calcium-mediated signaling using extracellular calcium source;GO:0035589|G protein-coupled purinergic nucleotide receptor signaling pathway;GO:0043270|positive regulation of ion transport;GO:0043491|protein kinase B signaling;GO:0045596|negative regulation of cell differentiation;GO:0048678|response to axon injury;GO:0050920|regulation of chemotaxis;GO:0050921|positive regulation of chemotaxis;GO:0051897|positive regulation of protein kinase B signaling;GO:0051924|regulation of calcium ion transport;GO:0070527|platelet aggregation;GO:0070588|calcium ion transmembrane transport;GO:0071318|cellular response to ATP;GO:0071407|cellular response to organic cyclic compound;GO:0071805|potassium ion transmembrane transport;GO:0150063|visual system development;GO:1900029|positive regulation of ruffle assembly;GO:1904139|regulation of microglial cell migration;GO:1904141|positive regulation of microglial cell migration;","GO:0005739|mitochondrion;GO:0005886|plasma membrane;GO:0005901|caveola;GO:0009897|external side of plasma membrane;GO:0009925|basal plasma membrane;GO:0016021|integral component of membrane;GO:0031224|intrinsic component of membrane;GO:0031253|cell projection membrane;GO:0044298|cell body membrane;","GO:0001609|G protein-coupled adenosine receptor activity;GO:0001621|ADP receptor activity;GO:0045028|G protein-coupled purinergic nucleotide receptor activity;","K04298","P2RY12; P2Y purinoceptor 12"]
["ENSRNOG00000046258",3,0.192991315,56,3.615464141,0.053379402,-4.227573041,{"v":8.66285e-14,"d":"8.66E-14"},{"v":1.09996E-13,"d":"1.10E-13"},"down","yes","B3gnt5","protein_coding","chr11:81140599-81156166:-","gi|281306748|ref|NP_446384.1|",2048,0,"lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase [Rattus norvegicus]","gi|672071646|ref|XM_008768849.1|",3852,0,"PREDICTED: Rattus norvegicus UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 (B3gnt5), transcript variant X1, mRNA","Q99NB2",793,0,"Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase",".",".",".",".","pfam01762","Galactosyl_T","Galactosyltransferase. This family includes the galactosyltransferases UDP-galactose:2-acetamido-2-deoxy-D-glucose3beta-galactosyltransferase and UDP-Gal:beta-GlcNAc beta 1,3-galactosyltranferase. Specific galactosyltransferases transfer galactose to GlcNAc terminal chains in the synthesis of the lacto-series oligosaccharides types 1 and 2.","GO:0006486|protein glycosylation;GO:0007417|central nervous system development;GO:0007420|brain development;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0008457|beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity;GO:0016757|transferase activity, transferring glycosyl groups;GO:0047256|lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity;","K03766","B3GNT5; beta-1,3-N-acetylglucosaminyltransferase 5 [EC:2.4.1.206]"]
["ENSRNOG00000025571",0,0.032165219,52,3.357216702,0.009580918,-6.705620337,{"v":1.15779e-13,"d":"1.16E-13"},{"v":1.45875E-13,"d":"1.46E-13"},"down","yes","Il19","protein_coding","chr13:42399138-42405473:-","gi|672027080|ref|XP_008760417.1|",928,{"v":9e-126,"d":"9.00E-126"},"PREDICTED: interleukin-19 [Rattus norvegicus]","gi|672027079|ref|XM_008762195.1|",531,0,"PREDICTED: Rattus norvegicus interleukin 19 (Il19), mRNA","Q8CJ70",301,{"v":4e-103,"d":"4.00E-103"},"Interleukin-19",".",".",".",".","pfam04523","Herpes_U30","Herpes virus tegument protein U30. This family is named after the human herpesvirus protein, but has been characterized in cytomegalovirus as UL47. Cytomegalovirus UL47 is a component of the tegument, which is a protein layer surrounding the viral capsid. UL47 co-precipitates with UL48 and UL69 tegument proteins, and the major capsid protein UL86. A UL47-containing complex is thought to be involved in the release of viral DNA from the disassembling virus particle.","GO:0008150|biological_process;GO:0010989|negative regulation of low-density lipoprotein particle clearance;GO:0072593|reactive oxygen species metabolic process;GO:2001235|positive regulation of apoptotic signaling pathway;GO:2001237|negative regulation of extrinsic apoptotic signaling pathway;GO:2001244|positive regulation of intrinsic apoptotic signaling pathway;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;","K05444","IL19; interleukin 19"]
["ENSRNOG00000010832",65,4.181478482,178,11.49201102,0.363859596,-1.458546237,{"v":1.22337E-13,"d":"1.22E-13"},{"v":1.54035e-13,"d":"1.54E-13"},"down","yes","Pdgfrl","protein_coding","chr16:51347948-51407850:-","gi|58865412|ref|NP_001011921.1|",1876,0,"platelet-derived growth factor receptor-like protein precursor [Rattus norvegicus]","gi|58865411|ref|NM_001011921.1|",1467,0,"Rattus norvegicus platelet-derived growth factor receptor-like (Pdgfrl), mRNA","Q5RJP7",727,0,"Platelet-derived growth factor receptor-like protein",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005576|extracellular region;","GO:0003674|molecular_function;","K25716","PDGFRL; platelet-derived growth factor receptor-like protein"]
["ENSRNOG00000009336",12,0.771965258,79,5.100386913,0.151354254,-2.723998867,{"v":1.27901e-13,"d":"1.28E-13"},{"v":1.60899E-13,"d":"1.61E-13"},"down","yes","Mapk15","protein_coding","chr7:107694964-107714645:+","gi|564360480|ref|XP_006241839.1|",2497,0,"PREDICTED: mitogen-activated protein kinase 15 isoform X2 [Rattus norvegicus]","gi|672059391|ref|XM_006241777.2|",2401,0,"PREDICTED: Rattus norvegicus mitogen-activated protein kinase 15 (Mapk15), transcript variant X1, mRNA","Q9Z2A6",885,0,"Mitogen-activated protein kinase 15",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0000165|MAPK cascade;GO:0001934|positive regulation of protein phosphorylation;GO:0003400|regulation of COPII vesicle coating;GO:0006468|protein phosphorylation;GO:0006974|cellular response to DNA damage stimulus;GO:0007029|endoplasmic reticulum organization;GO:0008156|negative regulation of DNA replication;GO:0008284|positive regulation of cell proliferation;GO:0010506|regulation of autophagy;GO:0030336|negative regulation of cell migration;GO:0031398|positive regulation of protein ubiquitination;GO:0032212|positive regulation of telomere maintenance via telomerase;GO:0032355|response to estradiol;GO:0035556|intracellular signal transduction;GO:0045732|positive regulation of protein catabolic process;GO:0046777|protein autophosphorylation;GO:0051973|positive regulation of telomerase activity;GO:0090494|dopamine uptake;GO:1902017|regulation of cilium assembly;GO:1904355|positive regulation of telomere capping;GO:1904491|protein localization to ciliary transition zone;GO:1905188|positive regulation of metaphase/anaphase transition of meiosis I;GO:1905832|positive regulation of spindle assembly;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005776|autophagosome;GO:0005794|Golgi apparatus;GO:0005814|centriole;GO:0005911|cell-cell junction;GO:0005923|bicellular tight junction;GO:0031410|cytoplasmic vesicle;GO:0036064|ciliary basal body;GO:0072687|meiotic spindle;","GO:0003682|chromatin binding;GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0004707|MAP kinase activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0016301|kinase activity;","K19603","MAPK15; mitogen-activated protein kinase 15 [EC:2.7.11.24]"]
["ENSRNOG00000012714",3,0.192991315,55,3.550902281,0.054349937,-4.201577832,{"v":1.57523e-13,"d":"1.58E-13"},{"v":1.97554e-13,"d":"1.98E-13"},"down","yes","RGD1564149","protein_coding","chr20:12175442-12187017:-","gi|119310195|ref|NP_001073176.1|",1009,{"v":2E-131,"d":"2.00E-131"},"uncharacterized protein C21orf58 homolog [Rattus norvegicus]","gi|119310194|ref|NM_001079708.1|",1502,0,"Rattus norvegicus similar to Protein C21orf58 (RGD1564149), mRNA",".",".",".",".",".",".",".",".","pfam15248","DUF4587","Domain of unknown function (DUF4587). This protein family is a domain of unknown function. The precise function of this protein domain remains to be elucidated. This domain family is found in eukaryotes, and is typically between 64 and 79 amino acids in length. There are two conserved sequence motifs: QNAQ and HHH. In humans, it is found in the position, chromosome 21 open reading frame 58.",".",".",".",".","."]
["ENSRNOG00000019659",32,2.058574022,120,7.747423159,0.265710802,-1.912071215,{"v":1.61509e-13,"d":"1.62E-13"},{"v":2.02464e-13,"d":"2.02E-13"},"down","yes","Aspa","protein_coding","chr10:57892104-57945272:-","gi|564372983|ref|XP_006246880.1|",1340,{"v":9e-172,"d":"9.00E-172"},"PREDICTED: aspartoacylase isoform X3 [Rattus norvegicus]","gi|104294891|gb|AC127738.4|",2831,0,"Rattus norvegicus BAC CH230-183I4 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q9R1T5",518,{"v":9e-172,"d":"9.00E-172"},"Aspartoacylase","alr3912",147,{"v":2e-37,"d":"2.00E-37"},"COG2988","pfam04952","AstE_AspA","Succinylglutamate desuccinylase / Aspartoacylase family. This family includes Succinylglutamate desuccinylase EC:3.1.-.- that catalyses the fifth and last step in arginine catabolism by the arginine succinyltransferase pathway. The family also include aspartoacylase EC:3.5.1.15 which cleaves acylaspartate into a fatty acid and aspartate. Mutations in human ASPA lead to Canavan disease disease. This family is probably structurally related to pfam00246 (Bateman A pers. obs.).","GO:0022010|central nervous system myelination;GO:0048714|positive regulation of oligodendrocyte differentiation;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0016788|hydrolase activity, acting on ester bonds;GO:0016811|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides;GO:0019807|aspartoacylase activity;GO:0042802|identical protein binding;GO:0046872|metal ion binding;","K01437","ASPA, aspA; aspartoacylase [EC:3.5.1.15]"]
["ENSRNOG00000046196",9,0.578973944,71,4.583892036,0.126306191,-2.985002737,{"v":1.89758E-13,"d":"1.90E-13"},{"v":2.37096e-13,"d":"2.37E-13"},"down","yes","Icos","protein_coding","chr9:62383832-62405672:+","gi|12018286|ref|NP_072132.1|",1065,{"v":2e-138,"d":"2.00E-138"},"inducible T-cell costimulator precursor [Rattus norvegicus]","gi|672065263|ref|XM_006245038.2|",2036,0,"PREDICTED: Rattus norvegicus inducible T-cell co-stimulator (Icos), transcript variant X3, mRNA","Q9R1T7",414,{"v":7e-140,"d":"7.00E-140"},"Inducible T-cell costimulator",".",".",".",".","pfam02961","BAF","Barrier to autointegration factor. The BAF protein has a SAM-domain-like bundle of orthogonally packed alpha-hairpins - one classic and one pseudo helix-hairpin-helix motif. The protein is involved in the prevention of retroviral DNA integration.","GO:0002517|T cell tolerance induction;GO:0031295|T cell costimulation;GO:0098609|cell-cell adhesion;","GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;","K06713","ICOS, AILIM, CD278; inducible T-cell co-stimulator"]
["ENSRNOG00000023856",0,0.032165219,51,3.292654842,9.768779E-3,-6.677605961,{"v":1.91314e-13,"d":"1.91E-13"},{"v":2.38831e-13,"d":"2.39E-13"},"down","yes","Agxt","protein_coding","chr9:93675384-93685336:+","gi|397529546|ref|NP_085914.2|",2098,0,"serine--pyruvate aminotransferase, mitochondrial isoform 1 precursor [Rattus norvegicus]","gi|397529545|ref|NM_030656.2|",1599,0,"Rattus norvegicus alanine-glyoxylate aminotransferase (Agxt), transcript variant 1, mRNA","P09139",812,0,"Serine--pyruvate aminotransferase, mitochondrial","alr1004",317,{"v":1e-101,"d":"1.00E-101"},"COG0075","pfam00266","Aminotran_5","Aminotransferase class-V. This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.","GO:0007219|Notch signaling pathway;GO:0009436|glyoxylate catabolic process;GO:0019265|glycine biosynthetic process, by transamination of glyoxylate;GO:0019448|L-cysteine catabolic process;GO:0042853|L-alanine catabolic process;GO:0042866|pyruvate biosynthetic process;GO:0046487|glyoxylate metabolic process;GO:0046724|oxalic acid secretion;GO:0051384|response to glucocorticoid;GO:0051591|response to cAMP;","GO:0005739|mitochondrion;GO:0005759|mitochondrial matrix;GO:0005777|peroxisome;GO:0005782|peroxisomal matrix;GO:0043231|intracellular membrane-bounded organelle;","GO:0003824|catalytic activity;GO:0004760|serine-pyruvate transaminase activity;GO:0008453|alanine-glyoxylate transaminase activity;GO:0008483|transaminase activity;GO:0016597|amino acid binding;GO:0030170|pyridoxal phosphate binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0043621|protein self-association;","K00830","AGXT; alanine-glyoxylate transaminase / serine-glyoxylate transaminase / serine-pyruvate transaminase [EC:2.6.1.44 2.6.1.45 2.6.1.51]"]
["ENSRNOG00000008922",22,1.41526964,100,6.456185966,0.219211412,-2.18960519,{"v":1.98317e-13,"d":"1.98E-13"},{"v":2.47411e-13,"d":"2.47E-13"},"down","yes","Trim14","protein_coding","chr5:60800032-60824858:-","gi|157817684|ref|NP_001101404.1|",1863,0,"tripartite motif-containing protein 14 [Rattus norvegicus]","gi|157817683|ref|NM_001107934.1|",3446,0,"Rattus norvegicus tripartite motif-containing 14 (Trim14), mRNA","Q8BVW3",598,0,"Tripartite motif-containing protein 14",".",".",".",".","pfam00622","SPRY","SPRY domain. SPRY Domain is named from SPla and the RYanodine Receptor. Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.","GO:0000209|protein polyubiquitination;GO:0008150|biological_process;GO:0010468|regulation of gene expression;GO:0010508|positive regulation of autophagy;GO:0016567|protein ubiquitination;GO:0032880|regulation of protein localization;GO:0032897|negative regulation of viral transcription;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045087|innate immune response;GO:0045893|positive regulation of transcription, DNA-templated;GO:0046596|regulation of viral entry into host cell;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051092|positive regulation of NF-kappaB transcription factor activity;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0003674|molecular_function;GO:0003713|transcription coactivator activity;GO:0008270|zinc ion binding;GO:0019901|protein kinase binding;GO:0042803|protein homodimerization activity;GO:0061630|ubiquitin protein ligase activity;","K12004","TRIM14; tripartite motif-containing protein 14"]
["ENSRNOG00000009590",67,4.310139358,180,11.62113474,0.370887995,-1.430944525,{"v":1.98593e-13,"d":"1.99E-13"},{"v":2.47701e-13,"d":"2.48E-13"},"down","yes","Stox2","protein_coding","chr16:44848078-45085105:+","gi|198442895|ref|NP_001128335.1|",4191,0,"storkhead-box protein 2 [Rattus norvegicus]","gi|556503418|ref|NM_001286376.1|",5892,0,"Mus musculus storkhead box 2 (Stox2), transcript variant 3, mRNA","Q499E5",1599,0,"Storkhead-box protein 2",".",".",".",".","pfam10264","Stork_head","Winged helix Storkhead-box1 domain. This is the conserved N-terminal winged helix domain of Storkhead-box1 protein which is likely to be a DNA binding domain. In humans the full-length protein controls polyploidization of extravillus trophoblast and is implicated in pre-eclampsia.","GO:0001893|maternal placenta development;GO:0006357|regulation of transcription by RNA polymerase II;GO:0009617|response to bacterium;GO:0009792|embryo development ending in birth or egg hatching;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003674|molecular_function;",".","."]
["ENSRNOG00000039544",85,5.468087246,208,13.42886681,0.40718903,-1.296229401,{"v":2.37178e-13,"d":"2.37E-13"},{"v":2.94862e-13,"d":"2.95E-13"},"down","yes","ENSRNOG00000039544","protein_coding","chrX:14662357-14677233:-","gi|157787183|ref|NP_001099218.1|",2985,0,"potassium voltage-gated channel subfamily D member 1 precursor [Rattus norvegicus]","gi|157787182|ref|NM_001105748.1|",3043,0,"Rattus norvegicus potassium voltage-gated channel subfamily D member 1 (Kcnd1), mRNA","Q03719",1125,0,"Potassium voltage-gated channel subfamily D member 1","STM1741",104,{"v":6e-23,"d":"6.00E-23"},"COG1226","pfam02214","BTB_2","BTB/POZ domain. In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.","GO:0034765|regulation of ion transmembrane transport;GO:0051260|protein homooligomerization;GO:0071805|potassium ion transmembrane transport;","GO:0008076|voltage-gated potassium channel complex;GO:0014069|postsynaptic density;GO:0016021|integral component of membrane;GO:0043025|neuronal cell body;GO:0043197|dendritic spine;GO:0045211|postsynaptic membrane;","GO:0005249|voltage-gated potassium channel activity;GO:0005250|A-type (transient outward) potassium channel activity;GO:0005515|protein binding;","K04891","KCND1, KV4.1; potassium voltage-gated channel Shal-related subfamily D member 1"]
["ENSRNOG00000063278",8,0.514643505,68,4.390206457,0.117225354,-3.092643461,{"v":2.4705e-13,"d":"2.47E-13"},{"v":3.07068e-13,"d":"3.07E-13"},"down","yes","ENSRNOG00000063278","protein_coding","chrX:117620634-117621287:-","gi|531171|gb|AAA86463.1|",999,{"v":3e-135,"d":"3.00E-135"},"Csa-19 [Homo sapiens]","gi|37231658|gb|BC058468.1|",618,0,"Rattus norvegicus ribosomal protein L10A, mRNA (cDNA clone MGC:72800 IMAGE:6919792), complete cds","P62907",389,{"v":1E-136,"d":"1.00E-136"},"60S ribosomal protein L10a","SPCC1183.08c",251,{"v":7e-83,"d":"7.00E-83"},"COG0081","pfam00687","Ribosomal_L1","Ribosomal protein L1p/L10e family. This family includes prokaryotic L1 and eukaryotic L10.",".",".",".",".","."]
["ENSRNOG00000025384",97,6.240052504,226,14.59098028,0.427665063,-1.22544674,{"v":2.70171e-13,"d":"2.70E-13"},{"v":3.35222E-13,"d":"3.35E-13"},"down","yes","Slc2a10","protein_coding","chr3:154240391-154252690:+","gi|157817670|ref|NP_001102433.1|",2290,0,"solute carrier family 2, facilitated glucose transporter member 10 [Rattus norvegicus]","gi|157817669|ref|NM_001108963.1|",3724,0,"Rattus norvegicus solute carrier family 2 member 10 (Slc2a10), mRNA","Q8VHD6",802,0,"Solute carrier family 2, facilitated glucose transporter member 10",".",".",".",".","pfam00083","Sugar_tr","Sugar (and other) transporter.","GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0030511|positive regulation of transforming growth factor beta receptor signaling pathway;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0032683|negative regulation of connective tissue growth factor production;GO:0043588|skin development;GO:0045454|cell redox homeostasis;GO:0060392|negative regulation of SMAD protein signal transduction;GO:0060840|artery development;GO:0070837|dehydroascorbic acid transport;GO:0072498|embryonic skeletal joint development;GO:0098708|glucose import across plasma membrane;GO:1902729|negative regulation of proteoglycan biosynthetic process;GO:1902730|positive regulation of proteoglycan biosynthetic process;GO:1903053|regulation of extracellular matrix organization;GO:2001045|negative regulation of integrin-mediated signaling pathway;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0048471|perinuclear region of cytoplasm;","GO:0033300|dehydroascorbic acid transmembrane transporter activity;GO:0055056|D-glucose transmembrane transporter activity;","K08147","SLC2A10, GLUT10; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 10"]
["ENSRNOG00000043249",1,0.064330438,49,3.163531123,0.02033501,-5.619890463,{"v":3.15397e-13,"d":"3.15E-13"},{"v":3.89814e-13,"d":"3.90E-13"},"down","yes","Pde4c","protein_coding","chr16:18711703-18715496:-","gi|564318760|ref|XP_006222235.1|",622,{"v":1e-74,"d":"1.00E-74"},"PREDICTED: putative protein TPRXL isoform X1 [Rattus norvegicus]","gi|672029242|ref|XM_006222173.2|",1338,0,"PREDICTED: Rattus norvegicus Pde4c protein-like (LOC100360908), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam09606","Med15","ARC105 or Med15 subunit of Mediator complex non-fungal. The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.","GO:0006198|cAMP catabolic process;GO:0007165|signal transduction;GO:0061179|negative regulation of insulin secretion involved in cellular response to glucose stimulus;","GO:0005634|nucleus;GO:0005829|cytosol;GO:0005929|cilium;GO:0048471|perinuclear region of cytoplasm;","GO:0004114|3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0004115|3',5'-cyclic-AMP phosphodiesterase activity;GO:0046872|metal ion binding;","K13293","PDE4; cAMP-specific phosphodiesterase 4 [EC:3.1.4.53]"]
["ENSRNOG00000039048",27,1.736921831,109,7.037242702,0.24681852,-2.018477442,{"v":3.17554e-13,"d":"3.18E-13"},{"v":3.92141E-13,"d":"3.92E-13"},"down","yes","Cd200r1","protein_coding","chr11:55887717-55921285:-","gi|13027398|ref|NP_076443.1|",1504,0,"cell surface glycoprotein CD200 receptor 1 precursor [Rattus norvegicus]","gi|672071194|ref|XM_008768743.1|",1760,0,"PREDICTED: Rattus norvegicus CD200 receptor 1 (Cd200r1), transcript variant X1, mRNA","Q9ES58",583,0,"Cell surface glycoprotein CD200 receptor 1",".",".",".",".","pfam08205","C2-set_2","CD80-like C2-set immunoglobulin domain. These domains belong to the immunoglobulin superfamily.","GO:0032715|negative regulation of interleukin-6 production;GO:0034113|heterotypic cell-cell adhesion;GO:0150077|regulation of neuroinflammatory response;GO:0150079|negative regulation of neuroinflammatory response;GO:1901215|negative regulation of neuron death;GO:1905522|negative regulation of macrophage migration;GO:2000405|negative regulation of T cell migration;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0043235|receptor complex;","GO:0038023|signaling receptor activity;GO:0086080|protein binding involved in heterotypic cell-cell adhesion;","K21668","CD200R; cell surface glycoprotein CD200 receptor"]
["ENSRNOG00000015821",21,1.350939202,97,6.262500387,0.215718821,-2.212776039,{"v":3.18995E-13,"d":"3.19E-13"},{"v":3.93665e-13,"d":"3.94E-13"},"down","yes","Cd2","protein_coding","chr2:188710900-188724026:-","gi|56972388|gb|AAH88164.1|",1466,0,"Cd2 molecule [Rattus norvegicus]","gi|6978626|ref|NM_012830.1|",1121,0,"Rattus norvegicus Cd2 molecule (Cd2), mRNA","P08921",569,0,"T-cell surface antigen CD2",".",".",".",".","pfam05790","C2-set","Immunoglobulin C2-set domain.","GO:0032729|positive regulation of interferon-gamma production;GO:0032757|positive regulation of interleukin-8 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0034113|heterotypic cell-cell adhesion;GO:0042110|T cell activation;GO:0098609|cell-cell adhesion;","GO:0005576|extracellular region;GO:0005911|cell-cell junction;GO:0009897|external side of plasma membrane;GO:0009898|cytoplasmic side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0032991|protein-containing complex;GO:0045121|membrane raft;GO:0046658|anchored component of plasma membrane;","GO:0005102|signaling receptor binding;GO:0005515|protein binding;GO:0019901|protein kinase binding;GO:0030971|receptor tyrosine kinase binding;GO:0042802|identical protein binding;GO:0043621|protein self-association;","K06449","CD2; T-cell surface glycoprotein CD2"]
["ENSRNOG00000018311",26,1.672591393,107,6.908118983,0.242119656,-2.046207888,{"v":3.24846e-13,"d":"3.25E-13"},{"v":4.00452e-13,"d":"4.00E-13"},"down","yes","Cd19","protein_coding","chr1:180987286-180993975:-","gi|201021269|ref|NP_001013255.2|",2211,0,"B-lymphocyte antigen CD19 precursor [Rattus norvegicus]","gi|686661098|ref|NM_001013237.3|",2281,0,"Rattus norvegicus CD19 molecule (Cd19), mRNA","P25918",760,0,"B-lymphocyte antigen CD19",".",".",".",".","pfam05255","UPF0220","Uncharacterized protein family (UPF0220). This family of proteins is functionally uncharacterized.","GO:0001923|B-1 B cell differentiation;GO:0002322|B cell proliferation involved in immune response;GO:0016064|immunoglobulin mediated immune response;GO:0019724|B cell mediated immunity;GO:0043552|positive regulation of phosphatidylinositol 3-kinase activity;GO:0050851|antigen receptor-mediated signaling pathway;GO:0050853|B cell receptor signaling pathway;GO:0050855|regulation of B cell receptor signaling pathway;GO:0050864|regulation of B cell activation;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;","GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0032991|protein-containing complex;",".","K06465","CD19; B-lymphocyte antigen CD19"]
["ENSRNOG00000013862",15,0.964956573,84,5.423196211,0.177931341,-2.490607447,{"v":3.5178e-13,"d":"3.52E-13"},{"v":4.33095e-13,"d":"4.33E-13"},"down","yes","Dusp2","protein_coding","chr3:114556325-114558499:+","gi|58865748|ref|NP_001012089.1|",1420,0,"dual specificity protein phosphatase 2 [Rattus norvegicus]","gi|58865747|ref|NM_001012089.1|",1623,0,"Rattus norvegicus dual specificity phosphatase 2 (Dusp2), mRNA","Q05922",536,0,"Dual specificity protein phosphatase 2","SPBC17A3.06",74.3,{"v":1E-13,"d":"1.00E-13"},"COG2453","pfam00782","DSPc","Dual specificity phosphatase, catalytic domain. Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a \"recognition\" region.","GO:0001706|endoderm formation;GO:0006470|protein dephosphorylation;GO:0043409|negative regulation of MAPK cascade;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0031965|nuclear membrane;","GO:0004721|phosphoprotein phosphatase activity;GO:0004725|protein tyrosine phosphatase activity;GO:0008330|protein tyrosine/threonine phosphatase activity;GO:0017017|MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0051019|mitogen-activated protein kinase binding;","K04459","DUSP, MKP; dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48]"]
["ENSRNOG00000036828",68,4.374469797,180,11.62113474,0.376423636,-1.409570874,{"v":3.68038e-13,"d":"3.68E-13"},{"v":4.52623e-13,"d":"4.53E-13"},"down","yes","Pde1b","protein_coding","chr7:134627322-134654580:+","gi|12083681|ref|NP_073201.1|",2632,0,"calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [Rattus norvegicus]","gi|298900757|emb|FQ212460.1|",2981,0,"Rattus norvegicus TL0AAA54YB23 mRNA sequence","Q01066",1018,0,"Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B",".",".",".",".","pfam00233","PDEase_I","3'5'-cyclic nucleotide phosphodiesterase.","GO:0001505|regulation of neurotransmitter levels;GO:0001975|response to amphetamine;GO:0007165|signal transduction;GO:0007626|locomotory behavior;GO:0008542|visual learning;GO:0030224|monocyte differentiation;GO:0036006|cellular response to macrophage colony-stimulating factor stimulus;GO:0042053|regulation of dopamine metabolic process;GO:0042428|serotonin metabolic process;GO:0097011|cellular response to granulocyte macrophage colony-stimulating factor stimulus;","GO:0005737|cytoplasm;GO:0043025|neuronal cell body;","GO:0004112|cyclic-nucleotide phosphodiesterase activity;GO:0004114|3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0004115|3',5'-cyclic-AMP phosphodiesterase activity;GO:0005516|calmodulin binding;GO:0046872|metal ion binding;GO:0047555|3',5'-cyclic-GMP phosphodiesterase activity;GO:0048101|calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity;","K13755","PDE1; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17]"]
["ENSRNOG00000005708",16,1.029287011,86,5.55231993,0.185379629,-2.431445374,{"v":3.92201e-13,"d":"3.92E-13"},{"v":4.81406e-13,"d":"4.81E-13"},"down","yes","Mmp16","protein_coding","chr5:31312280-31548388:+","gi|466040332|ref|XP_004276191.1|",3008,0,"PREDICTED: matrix metalloproteinase-16 [Orcinus orca]","gi|672052136|ref|XM_006237921.2|",3521,0,"PREDICTED: Rattus norvegicus matrix metallopeptidase 16 (Mmp16), transcript variant X1, mRNA","Q9WTR0",1161,0,"Matrix metalloproteinase-16","MA4674",54.7,3e-07,"COG5549","pfam00413","Peptidase_M10","Matrixin. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.","GO:0001501|skeletal system development;GO:0001503|ossification;GO:0001958|endochondral ossification;GO:0006508|proteolysis;GO:0016485|protein processing;GO:0030198|extracellular matrix organization;GO:0030574|collagen catabolic process;GO:0035988|chondrocyte proliferation;GO:0048701|embryonic cranial skeleton morphogenesis;GO:0060348|bone development;GO:0097094|craniofacial suture morphogenesis;GO:1990834|response to odorant;","GO:0005576|extracellular region;GO:0005887|integral component of plasma membrane;GO:0031012|extracellular matrix;","GO:0004222|metalloendopeptidase activity;GO:0008270|zinc ion binding;GO:0070006|metalloaminopeptidase activity;","K07996","MMP16; matrix metalloproteinase-16 (membrane-inserted) [EC:3.4.24.-]"]
["ENSRNOG00000002831",41,2.637547966,134,8.651289194,0.304873402,-1.713717805,{"v":4.77985e-13,"d":"4.78E-13"},{"v":5.85067e-13,"d":"5.85E-13"},"down","yes","Wfikkn2","protein_coding","chr10:79186647-79191657:-","gi|27675188|ref|XP_220855.1|",2741,0,"PREDICTED: WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 isoform X2 [Rattus norvegicus]","gi|672069181|ref|XM_220855.8|",2541,0,"PREDICTED: Rattus norvegicus WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 (Wfikkn2), transcript variant X2, mRNA","Q7TQN3",1045,0,"WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2",".",".",".",".","pfam00014","Kunitz_BPTI","Kunitz/Bovine pancreatic trypsin inhibitor domain. Indicative of a protease inhibitor, usually a serine protease inhibitor. Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure. Certain family members are similar to the tick anticoagulant peptide (TAP). This is a highly selective inhibitor of factor Xa in the blood coagulation pathways. TAP molecules are highly dipolar, and are arranged to form a twisted two- stranded antiparallel beta-sheet followed by an alpha helix.","GO:0001501|skeletal system development;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0010951|negative regulation of endopeptidase activity;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0032091|negative regulation of protein binding;GO:0043392|negative regulation of DNA binding;GO:0055001|muscle cell development;GO:0060021|roof of mouth development;GO:2000272|negative regulation of signaling receptor activity;","GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0004867|serine-type endopeptidase inhibitor activity;GO:0008191|metalloendopeptidase inhibitor activity;GO:0048019|receptor antagonist activity;GO:0050431|transforming growth factor beta binding;","K23621","WFIKKN; WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein"]
["ENSRNOG00000055433",45,2.894869718,141,9.103222211,0.318004949,-1.652878875,{"v":4.8166e-13,"d":"4.82E-13"},{"v":5.89186e-13,"d":"5.89E-13"},"down","yes","Trim46","protein_coding","chr2:174641496-174654141:-","gi|674036948|ref|XP_008852505.1|",3817,0,"PREDICTED: tripartite motif-containing protein 46 isoform X4 [Nannospalax galili]","gi|672042997|ref|XM_008761170.1|",3007,0,"PREDICTED: Rattus norvegicus tripartite motif-containing 46 (Trim46), transcript variant X1, mRNA","A0A0G2JXN2",1467,0,"Tripartite motif-containing protein 46",".",".",".",".","pfam00643","zf-B_box","B-box zinc finger.","GO:0000226|microtubule cytoskeleton organization;GO:0001578|microtubule bundle formation;GO:0001764|neuron migration;GO:0007409|axonogenesis;GO:0030517|negative regulation of axon extension;GO:0048490|anterograde synaptic vesicle transport;GO:0099612|protein localization to axon;GO:1901953|positive regulation of anterograde dense core granule transport;GO:1903827|regulation of cellular protein localization;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0043194|axon initial segment;GO:0044304|main axon;GO:1904115|axon cytoplasm;GO:1990769|proximal neuron projection;","GO:0008270|zinc ion binding;","K12022","TRIM46; tripartite motif-containing protein 46"]
["ENSRNOG00000026650",0,0.032165219,49,3.163531123,0.010167505,-6.619890463,{"v":5.2524e-13,"d":"5.25E-13"},{"v":6.41396e-13,"d":"6.41E-13"},"down","yes","Tmprss4","protein_coding","chr8:45476053-45508409:-","gi|157823543|ref|NP_001102468.1|",2332,0,"transmembrane protease serine 4 [Rattus norvegicus]","gi|157823542|ref|NM_001108998.1|",2235,0,"Rattus norvegicus transmembrane protease, serine 4 (Tmprss4), mRNA","Q8VCA5",805,0,"Transmembrane protease serine 4","VC1649",117,{"v":9e-27,"d":"9.00E-27"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;GO:0006897|endocytosis;GO:0009611|response to wounding;GO:0010468|regulation of gene expression;GO:0016485|protein processing;GO:0045967|negative regulation of growth rate;GO:0046598|positive regulation of viral entry into host cell;","GO:0005615|extracellular space;GO:0016021|integral component of membrane;GO:0030141|secretory granule;","GO:0004252|serine-type endopeptidase activity;GO:0005044|scavenger receptor activity;GO:0008236|serine-type peptidase activity;","K09635","TMPRSS4; transmembrane protease serine 4 [EC:3.4.21.-]"]
["ENSRNOG00000008901",1,0.064330438,48,3.098969263,0.020758656,-5.59014312,{"v":5.52139e-13,"d":"5.52E-13"},{"v":6.73161E-13,"d":"6.73E-13"},"down","yes","Coro2a","protein_coding","chr5:60828247-60859035:-","gi|404501476|ref|NP_001012101.2|",2755,0,"coronin-2A [Rattus norvegicus]","gi|404501475|ref|NM_001012101.2|",2040,0,"Rattus norvegicus coronin 2A (Coro2a), mRNA","Q8C0P5",1014,0,"Coronin-2A",".",".",".",".","pfam08954","DUF1900","Domain of unknown function (DUF1900). This domain is predominantly found in the structural protein coronin, and is duplicated in some sequences. It has no known function.",".","GO:0005903|brush border;GO:0017053|transcriptional repressor complex;","GO:0051015|actin filament binding;","K13887","CORO2; coronin-2"]
["ENSRNOG00000004155",45,2.894869718,140,9.038660352,0.320276413,-1.64261054,{"v":7.35418e-13,"d":"7.35E-13"},{"v":8.91951e-13,"d":"8.92E-13"},"down","yes","Samd14","protein_coding","chr10:79957758-79972341:+","gi|68163407|ref|NP_001020137.1|",1527,0,"sterile alpha motif domain-containing protein 14 [Rattus norvegicus]","gi|68163406|ref|NM_001024966.1|",2714,0,"Rattus norvegicus sterile alpha motif domain containing 14 (Samd14), mRNA",".",".",".",".",".",".",".",".","pfam00536","SAM_1","SAM domain (Sterile alpha motif). It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.","GO:0007015|actin filament organization;GO:0019722|calcium-mediated signaling;GO:0031175|neuron projection development;","GO:0005737|cytoplasm;GO:0014069|postsynaptic density;GO:0015629|actin cytoskeleton;GO:0030425|dendrite;","GO:0051015|actin filament binding;",".","."]
["ENSRNOG00000001726",97,6.240052504,223,14.3972947,0.433418405,-1.206167677,{"v":7.52646e-13,"d":"7.53E-13"},{"v":9.12459e-13,"d":"9.12E-13"},"down","yes","Tmem44","protein_coding","chr11:70181345-70216958:+","gi|149027229|gb|EDL82927.1|",1806,0,"similar to transmembrane protein 44 isoform a (predicted), isoform CRA_a [Rattus norvegicus]","gi|564314036|ref|XM_006221048.1|",1930,0,"PREDICTED: Rattus norvegicus transmembrane protein 44 (Tmem44), transcript variant X1, mRNA","Q2T9K0",478,{"v":1e-158,"d":"1.00E-158"},"Transmembrane protein 44",".",".",".",".","pfam15449","Retinal","Retinal protein. This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000023686",5,0.321652191,58,3.74458786,0.085897889,-3.54123352,{"v":7.92143e-13,"d":"7.92E-13"},{"v":9.59324e-13,"d":"9.59E-13"},"down","yes","Upk3b","protein_coding","chr12:20631525-20637724:-","gi|109495568|ref|XP_341057.3|",1215,{"v":3e-164,"d":"3.00E-164"},"PREDICTED: uroplakin-3b isoform X2 [Rattus norvegicus]","gi|672072770|ref|XM_341056.7|",1158,0,"PREDICTED: Rattus norvegicus uroplakin 3B (Upk3b), transcript variant X2, mRNA","Q80YF6",442,{"v":1E-153,"d":"1.00E-153"},"Uroplakin-3b",".",".",".",".","pfam11343","DUF3145","Protein of unknown function (DUF3145). This family of proteins with unknown function appear to be restricted to Actinobacteria.","GO:0010629|negative regulation of gene expression;GO:0046325|negative regulation of glucose import;","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000015157",20,1.286608764,93,6.004252948,0.214282905,-2.222411336,{"v":8.46383e-13,"d":"8.46E-13"},{"v":1.02328e-12,"d":"1.02E-12"},"down","yes","Smtnl2","protein_coding","chr10:57008327-57029505:-","gi|300360521|ref|NP_001177927.1|",1967,0,"smoothelin-like protein 2 [Rattus norvegicus]","gi|300360520|ref|NM_001190998.1|",2438,0,"Rattus norvegicus smoothelin-like 2 (Smtnl2), mRNA",".",".",".",".","SPAC15A10.08",94.7,{"v":3e-19,"d":"3.00E-19"},"COG5069","pfam00307","CH","Calponin homology (CH) domain. The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.","GO:0030036|actin cytoskeleton organization;GO:0045907|positive regulation of vasoconstriction;","GO:0005815|microtubule organizing center;GO:0031430|M band;GO:0031674|I band;GO:0031941|filamentous actin;","GO:0005523|tropomyosin binding;GO:0008157|protein phosphatase 1 binding;",".","."]
["ENSRNOG00000070894",0,0.032165219,48,3.098969263,0.010379328,-6.59014312,{"v":8.72737e-13,"d":"8.73E-13"},{"v":1.05402E-12,"d":"1.05E-12"},"down","yes","ENSRNOG00000070894","lncRNA","chr14:1386849-1388083:+","gi|444727031|gb|ELW67540.1|",393,{"v":2e-42,"d":"2.00E-42"},"hypothetical protein TREES_T100003967 [Tupaia chinensis]","gi|269954751|gb|AC103314.7|",1235,0,"Rattus norvegicus Rf4 BAC CH230-160G3 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","A0A286YF58",146,{"v":5e-38,"d":"5.00E-38"},"Transmembrane protein 271",".",".",".",".","pfam15394","DUF4616","Domain of unknown function (DUF4616). This protein family is a domain of unknown function found at the C-terminal domain of the proteins. This protein family is found in eukaryotes. Proteins in this family are typically between 166 and 538 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000026432",7,0.450313067,63,4.067397158,0.110712834,-3.175105621,{"v":9.93041e-13,"d":"9.93E-13"},{"v":1.19704e-12,"d":"1.20E-12"},"down","yes","Syt7","protein_coding","chr1:207031592-207089026:+","gi|564332916|ref|XP_006231127.1|",3187,0,"PREDICTED: synaptotagmin-7 isoform X1 [Rattus norvegicus]","gi|12667441|gb|AF336852.1|AF336852",2187,0,"Rattus norvegicus synaptotagmin VIIT1 (SytVII) mRNA, complete cds, alternatively spliced","Q62747",628,0,"Synaptotagmin-7","YOR086c",64.7,{"v":9e-10,"d":"9.00E-10"},"COG5038","pfam00168","C2","C2 domain.","GO:0001778|plasma membrane repair;GO:0005513|detection of calcium ion;GO:0006909|phagocytosis;GO:0014059|regulation of dopamine secretion;GO:0016192|vesicle-mediated transport;GO:0017156|calcium ion regulated exocytosis;GO:0017158|regulation of calcium ion-dependent exocytosis;GO:0036465|synaptic vesicle recycling;GO:0045956|positive regulation of calcium ion-dependent exocytosis;GO:0046850|regulation of bone remodeling;GO:0048791|calcium ion-regulated exocytosis of neurotransmitter;GO:0050764|regulation of phagocytosis;GO:0050796|regulation of insulin secretion;GO:0070092|regulation of glucagon secretion;GO:0071277|cellular response to calcium ion;GO:0090119|vesicle-mediated cholesterol transport;GO:0090385|phagosome-lysosome fusion;GO:0099502|calcium-dependent activation of synaptic vesicle fusion;GO:1900242|regulation of synaptic vesicle endocytosis;GO:1990926|short-term synaptic potentiation;GO:1990927|calcium ion regulated lysosome exocytosis;","GO:0005764|lysosome;GO:0005765|lysosomal membrane;GO:0005777|peroxisome;GO:0005778|peroxisomal membrane;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0008021|synaptic vesicle;GO:0030425|dendrite;GO:0030670|phagocytic vesicle membrane;GO:0030672|synaptic vesicle membrane;GO:0031045|dense core granule;GO:0032009|early phagosome;GO:0042734|presynaptic membrane;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0043679|axon terminus;GO:0070382|exocytic vesicle;GO:0098686|hippocampal mossy fiber to CA3 synapse;GO:0098978|glutamatergic synapse;GO:0098982|GABA-ergic synapse;GO:0099056|integral component of presynaptic membrane;","GO:0000149|SNARE binding;GO:0001786|phosphatidylserine binding;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0005516|calmodulin binding;GO:0005544|calcium-dependent phospholipid binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0019905|syntaxin binding;GO:0030276|clathrin binding;","K19907","SYT7; synaptotagmin-7"]
["ENSRNOG00000016012",99,6.36871338,225,14.52641842,0.438422824,-1.18960519,{"v":1.05512e-12,"d":"1.06E-12"},{"v":1.27026e-12,"d":"1.27E-12"},"down","yes","Spats2l","protein_coding","chr9:59320276-59493967:+","gi|148667641|gb|EDL00058.1|",3023,0,"RIKEN cDNA 2810022L02, isoform CRA_c, partial [Mus musculus]","gi|672065181|ref|XM_006244992.2|",2336,0,"PREDICTED: Rattus norvegicus spermatogenesis associated, serine-rich 2-like (Spats2l), transcript variant X3, mRNA","Q5U2T3",1115,0,"SPATS2-like protein",".",".",".",".","pfam07139","DUF1387","Protein of unknown function (DUF1387). This family represents a conserved region approximately 300 residues long within a number of hypothetical proteins of unknown function that seem to be restricted to mammals.",".","GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0032991|protein-containing complex;",".",".","."]
["ENSRNOG00000020105",40,2.573217527,130,8.393041755,0.306589387,-1.705620337,{"v":1.25695E-12,"d":"1.26E-12"},{"v":1.50974E-12,"d":"1.51E-12"},"down","yes","Klhl30","protein_coding","chr9:91942504-91952730:+","gi|293349933|ref|XP_001067145.2|",3056,0,"PREDICTED: kelch-like protein 30 [Rattus norvegicus]","gi|672066084|ref|XM_003750733.2|",2057,0,"PREDICTED: Rattus norvegicus kelch-like family member 30 (Klhl30), mRNA","Q8C3F7",1137,0,"Kelch-like protein 30",".",".",".",".","pfam07707","BACK","BTB And C-terminal Kelch. This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).",".",".",".","K10466","KLHL30; kelch-like protein 30"]
["ENSRNOG00000068566",8,0.514643505,65,4.196520878,0.122635755,-3.027548432,{"v":1.38013e-12,"d":"1.38E-12"},{"v":1.65352E-12,"d":"1.65E-12"},"down","yes","Msx1","pseudogene","chr14:72961148-72964966:+","gi|149047351|gb|EDM00021.1|",1060,{"v":3e-137,"d":"3.00E-137"},"homeo box, msh-like 1, isoform CRA_b [Rattus norvegicus]","gi|13592000|ref|NM_031059.1|",1644,0,"Rattus norvegicus msh homeobox 1 (Msx1), mRNA","P13297",412,{"v":1e-138,"d":"1.00E-138"},"Homeobox protein MSX-1",".",".",".",".","pfam00046","Homeobox","Homeobox domain.",".",".",".",".","."]
["ENSRNOG00000009533",0,0.032165219,47,3.034407404,0.010600165,-6.559769471,{"v":1.45292E-12,"d":"1.45E-12"},{"v":1.73891e-12,"d":"1.74E-12"},"down","yes","Erich3","protein_coding","chr2:243615872-243715317:+","gi|672016444|ref|XP_008773501.1|",7295,0,"PREDICTED: glutamate-rich protein 3 [Rattus norvegicus]","gi|672044580|ref|XM_008761572.1|",3360,0,"PREDICTED: Rattus norvegicus glutamate-rich 3 (Erich3), mRNA",".",".",".",".",".",".",".",".","pfam15257","DUF4590","Domain of unknown function (DUF4590). This family of proteins remains to be characterized and is a domain of unknown function. This domain family is found in eukaryotes, and is approximately 120 amino acids in length. There are two conserved sequence motifs: CCE and PCY. In humans, the gene encoding this protein lies in the position, chromosome 1 open reading frame 173.",".",".",".",".","."]
["ENSRNOG00000016543",14,0.900626135,79,5.100386913,0.176579963,-2.501606445,{"v":1.54034e-12,"d":"1.54E-12"},{"v":1.83968e-12,"d":"1.84E-12"},"down","yes","Trim63","protein_coding","chr5:146533507-146547322:+","gi|18266714|ref|NP_543179.1|",1740,0,"E3 ubiquitin-protein ligase TRIM63 [Rattus norvegicus]","gi|38197349|gb|BC061824.1|",1847,0,"Rattus norvegicus tripartite motif-containing 63, mRNA (cDNA clone MGC:72330 IMAGE:5599072), complete cds","Q91Z63",674,0,"E3 ubiquitin-protein ligase TRIM63",".",".",".",".","pfam13923","zf-C3HC4_2","Zinc finger, C3HC4 type (RING finger).","GO:0006513|protein monoubiquitination;GO:0006936|muscle contraction;GO:0010468|regulation of gene expression;GO:0010614|negative regulation of cardiac muscle hypertrophy;GO:0014732|skeletal muscle atrophy;GO:0014878|response to electrical stimulus involved in regulation of muscle adaptation;GO:0014894|response to denervation involved in regulation of muscle adaptation;GO:0016567|protein ubiquitination;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051384|response to glucocorticoid;GO:0070555|response to interleukin-1;GO:0071549|cellular response to dexamethasone stimulus;","GO:0000151|ubiquitin ligase complex;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0030018|Z disc;GO:0031430|M band;GO:0043292|contractile fiber;","GO:0004842|ubiquitin-protein transferase activity;GO:0008270|zinc ion binding;GO:0031432|titin binding;GO:0061630|ubiquitin protein ligase activity;","K10655","TRIM63, MURF1; tripartite motif-containing protein 63 [EC:2.3.2.27]"]
["ENSRNOG00000026764",4,0.257321753,54,3.486340421,0.073808556,-3.760068122,{"v":1.60465E-12,"d":"1.60E-12"},{"v":1.91489e-12,"d":"1.91E-12"},"down","yes","Pla2g4c","protein_coding","chr1:74236211-74274656:+","gi|564326380|ref|XP_006228397.1|",3259,0,"PREDICTED: cytosolic phospholipase A2 gamma-like isoform X3 [Rattus norvegicus]","gi|672035342|ref|XM_008759024.1|",2408,0,"PREDICTED: Rattus norvegicus similar to phospholipase A2, group IVC (cytosolic, calcium-independent) (LOC691813), transcript variant X5, mRNA","Q64GA5",917,0,"Cytosolic phospholipase A2 gamma",".",".",".",".","pfam01735","PLA2_B","Lysophospholipase catalytic domain. This family consists of Lysophospholipase / phospholipase B EC:3.1.1.5 and cytosolic phospholipase A2 EC:3.1.4 which also has a C2 domain pfam00168. Phospholipase B enzymes catalyse the release of fatty acids from lysophsopholipids and are capable in vitro of hydrolysing all phospholipids extractable form yeast cells. Cytosolic phospholipase A2 associates with natural membranes in response to physiological increases in Ca2+ and selectively hydrolyses arachidonyl phospholipids, the aligned region corresponds the the carboxy-terminal Ca2+-independent catalytic domain of the protein as discussed in.","GO:0006663|platelet activating factor biosynthetic process;GO:0036151|phosphatidylcholine acyl-chain remodeling;GO:0036152|phosphatidylethanolamine acyl-chain remodeling;GO:0046475|glycerophospholipid catabolic process;GO:0140042|lipid droplet formation;","GO:0005635|nuclear envelope;GO:0005654|nucleoplasm;GO:0005789|endoplasmic reticulum membrane;GO:0005811|lipid droplet;GO:0005829|cytosol;GO:0005938|cell cortex;GO:0031966|mitochondrial membrane;","GO:0004622|lysophospholipase activity;GO:0004623|phospholipase A2 activity;GO:0005509|calcium ion binding;GO:0005544|calcium-dependent phospholipid binding;GO:0008374|O-acyltransferase activity;GO:0047498|calcium-dependent phospholipase A2 activity;GO:0047499|calcium-independent phospholipase A2 activity;","K16342","PLA2G4, CPLA2; cytosolic phospholipase A2 [EC:3.1.1.4]"]
["ENSRNOG00000012301",3,0.192991315,51,3.292654842,0.058612677,-4.092643461,{"v":1.72788e-12,"d":"1.73E-12"},{"v":2.0555e-12,"d":"2.06E-12"},"down","yes","Cfap161","protein_coding","chr1:137743784-137768730:-","gi|189181712|ref|NP_001094051.1|",1602,0,"uncharacterized protein C15orf26 homolog [Rattus norvegicus]","gi|189181711|ref|NM_001100581.1|",1319,0,"Rattus norvegicus cilia and flagella associated protein 161 (Cfap161), mRNA","Q6P8Y0",551,0,"Cilia- and flagella-associated protein 161",".",".",".",".","pfam01494","FAD_binding_3","FAD binding domain. This domain is involved in FAD binding in a number of enzymes.","GO:0060271|cilium assembly;","GO:0031514|motile cilium;",".",".","."]
["ENSRNOG00000060137",57,3.666834977,158,10.20077383,0.359466354,-1.476071353,{"v":1.81792E-12,"d":"1.82E-12"},{"v":2.16081E-12,"d":"2.16E-12"},"down","yes","AABR07037489.1","protein_coding","chrX:21447361-21471498:-","gi|11560067|ref|NP_071591.1|",1982,0,"probable G-protein coupled receptor 173 [Rattus norvegicus]","gi|924182915|ref|NM_027543.4|",2763,0,"Mus musculus G-protein coupled receptor 173 (Gpr173), transcript variant 1, mRNA","Q9JJH2",768,0,"Probable G-protein coupled receptor 173",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.",".",".",".",".","."]
["ENSRNOG00000005807",28,1.801252269,107,6.908118983,0.260744245,-1.939292684,{"v":2.03322e-12,"d":"2.03E-12"},{"v":2.4127E-12,"d":"2.41E-12"},"down","yes","Ptpn7","protein_coding","chr13:46571712-46583308:+","gi|21728414|ref|NP_663716.1|",1680,0,"tyrosine-protein phosphatase non-receptor type 7 [Rattus norvegicus]","gi|672074008|ref|XM_006249821.2|",1806,0,"PREDICTED: Rattus norvegicus protein tyrosine phosphatase, non-receptor type 7 (Ptpn7), transcript variant X2, mRNA","P49445",651,0,"Tyrosine-protein phosphatase non-receptor type 7","SPAC11E3.09",120,{"v":1e-28,"d":"1.00E-28"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0006470|protein dephosphorylation;GO:0035335|peptidyl-tyrosine dephosphorylation;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0009898|cytoplasmic side of plasma membrane;GO:0015630|microtubule cytoskeleton;GO:0072686|mitotic spindle;","GO:0004725|protein tyrosine phosphatase activity;","K18019","PTPN7; tyrosine-protein phosphatase non-receptor type 7 [EC:3.1.3.48]"]
["ENSRNOG00000023557",0,0.032165219,46,2.969845544,0.010830603,-6.528742575,{"v":2.42355e-12,"d":"2.42E-12"},{"v":2.86754e-12,"d":"2.87E-12"},"down","yes","Mab21l4","protein_coding","chr9:93690999-93700506:-","gi|157818261|ref|NP_001102781.1|",2201,0,"uncharacterized protein C2orf54 homolog [Rattus norvegicus]","gi|157818260|ref|NM_001109311.1|",2298,0,"Rattus norvegicus similar to hypothetical protein FLJ22671 (RGD1563692), mRNA",".",".",".",".",".",".",".",".","pfam03281","Mab-21","Mab-21 protein. This family contains Mab-21 and Mab-21 like proteins. In C. elegans these proteins are required for several aspects of embryonic development.",".",".",".",".","."]
["ENSRNOG00000068561",0,0.032165219,46,2.969845544,0.010830603,-6.528742575,{"v":2.42355e-12,"d":"2.42E-12"},{"v":2.86754e-12,"d":"2.87E-12"},"down","yes","ENSRNOG00000068561","protein_coding","chr11:64531612-64533989:+","gi|564314485|ref|XP_006221213.1|",537,{"v":4e-68,"d":"4.00E-68"},"PREDICTED: stefin-2-like isoform X1 [Rattus norvegicus]","gi|564314484|ref|XM_006221151.1|",403,0,"PREDICTED: Rattus norvegicus stefin A2-like 3 (Stfa2l3), transcript variant X1, mRNA","P35174",159,{"v":5e-49,"d":"5.00E-49"},"Stefin-2",".",".",".",".","pfam00031","Cystatin","Cystatin domain. Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 are related to this family but have not been included.",".",".",".",".","."]
["ENSRNOG00000069427",0,0.032165219,46,2.969845544,0.010830603,-6.528742575,{"v":2.42355e-12,"d":"2.42E-12"},{"v":2.86754e-12,"d":"2.87E-12"},"down","yes","ENSRNOG00000069427","protein_coding","chr4:99536972-99558699:-","gi|58222722|gb|AAW68992.1|",212,{"v":1e-19,"d":"1.00E-19"},"anti-tetanus toxoid immunoglobulin light chain variable region [Homo sapiens]","gi|830720277|gb|KP709023.1|",110,{"v":6E-49,"d":"6.00E-49"},"Rattus norvegicus strain BioBreeding (BB) IC2 immunoglobulin kappa light chain (IC2) gene, partial cds","A0A075B6S5",80.9,{"v":6e-19,"d":"6.00E-19"},"Immunoglobulin kappa variable 1-27",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000013748",1,0.064330438,45,2.905283684,0.022142567,-5.497033716,{"v":2.99019e-12,"d":"2.99E-12"},{"v":3.52413e-12,"d":"3.52E-12"},"down","yes","Trem3","protein_coding","chr9:12749852-12760779:-","gi|300797456|ref|NP_001178510.1|",922,{"v":5e-119,"d":"5.00E-119"},"triggering receptor expressed on myeloid cells 3 precursor [Rattus norvegicus]","gi|300797455|ref|NM_001191581.1|",893,0,"Rattus norvegicus triggering receptor expressed on myeloid cells 3 (Trem3), mRNA","Q9JKE2",100,{"v":2e-22,"d":"2.00E-22"},"Triggering receptor expressed on myeloid cells 1",".",".",".",".","pfam02666","PS_Dcarbxylase","Phosphatidylserine decarboxylase. This is a family of phosphatidylserine decarboxylases, EC:4.1.1.65.  These enzymes catalyse the reaction: Phosphatidyl-L-serine <=> phosphatidylethanolamine + CO2. Phosphatidylserine decarboxylase plays a central role in the biosynthesis of aminophospholipids by converting phosphatidylserine to phosphatidylethanolamine.","GO:0002367|cytokine production involved in immune response;GO:0030593|neutrophil chemotaxis;GO:0032602|chemokine production;GO:0045089|positive regulation of innate immune response;GO:0070945|neutrophil mediated killing of gram-negative bacterium;GO:0072672|neutrophil extravasation;","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000002540",43,2.766208842,133,8.586727334,0.322149375,-1.6341983,{"v":3.2745e-12,"d":"3.27E-12"},{"v":3.85218e-12,"d":"3.85E-12"},"down","yes","Rhoh","protein_coding","chr14:42337751-42386369:-","gi|61740627|ref|NP_001013448.1|",1024,{"v":3E-124,"d":"3.00E-124"},"rho-related GTP-binding protein RhoH [Rattus norvegicus]","gi|61740626|ref|NM_001013430.1|",1251,0,"Rattus norvegicus ras homolog family member H (Rhoh), mRNA","Q9D3G9",394,{"v":2e-124,"d":"2.00E-124"},"Rho-related GTP-binding protein RhoH","SPAC110.03",156,{"v":3e-41,"d":"3.00E-41"},"COG1100","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0007015|actin filament organization;GO:0007163|establishment or maintenance of cell polarity;GO:0008045|motor neuron axon guidance;GO:0008360|regulation of cell shape;GO:0016601|Rac protein signal transduction;GO:0030031|cell projection assembly;GO:0030217|T cell differentiation;GO:0030865|cortical cytoskeleton organization;GO:0032956|regulation of actin cytoskeleton organization;GO:0043086|negative regulation of catalytic activity;GO:0043124|negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043652|engulfment of apoptotic cell;GO:0045576|mast cell activation;GO:0045582|positive regulation of T cell differentiation;GO:1902622|regulation of neutrophil migration;","GO:0001772|immunological synapse;GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0005938|cell cortex;GO:0031410|cytoplasmic vesicle;GO:0042995|cell projection;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0019210|kinase inhibitor activity;GO:0019901|protein kinase binding;","K07873","RHOH, TTF; Ras homolog gene family, member H"]
["ENSRNOG00000069744",6,0.385982629,58,3.74458786,0.103077466,-3.278199114,{"v":3.9291e-12,"d":"3.93E-12"},{"v":4.60315e-12,"d":"4.60E-12"},"down","yes","ENSRNOG00000069744","protein_coding","chr4:162150446-162231395:-","gi|214831182|ref|NP_001135776.1|",1026,{"v":1E-134,"d":"1.00E-134"},"C-type lectin domain family 2 member d4 [Rattus norvegicus]","gi|298884091|emb|FQ229900.1|",946,0,"Rattus norvegicus TL0ADA46YE20 mRNA sequence","A4KWA6",355,{"v":9e-119,"d":"9.00E-119"},"C-type lectin domain family 2 member D3",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type",".",".",".",".","."]
["ENSRNOG00000010063",13,0.836295696,75,4.842139474,0.172712021,-2.533559592,{"v":3.95035E-12,"d":"3.95E-12"},{"v":4.62709e-12,"d":"4.63E-12"},"down","yes","Htr2a","protein_coding","chr15:49950804-50020928:+","gi|8393583|ref|NP_058950.1|",2439,0,"5-hydroxytryptamine receptor 2A [Rattus norvegicus]","gi|204672|gb|M64867.1|RATHTR2",3590,0,"Rat serotonin receptor mRNA","P14842",944,0,"5-hydroxytryptamine receptor 2A",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001659|temperature homeostasis;GO:0006874|cellular calcium ion homeostasis;GO:0007187|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007202|activation of phospholipase C activity;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007208|phospholipase C-activating serotonin receptor signaling pathway;GO:0007268|chemical synaptic transmission;GO:0007568|aging;GO:0007613|memory;GO:0008219|cell death;GO:0008284|positive regulation of cell proliferation;GO:0009410|response to xenobiotic stimulus;GO:0010513|positive regulation of phosphatidylinositol biosynthetic process;GO:0014059|regulation of dopamine secretion;GO:0014065|phosphatidylinositol 3-kinase signaling;GO:0014824|artery smooth muscle contraction;GO:0014832|urinary bladder smooth muscle contraction;GO:0019233|sensory perception of pain;GO:0030431|sleep;GO:0033674|positive regulation of kinase activity;GO:0043267|negative regulation of potassium ion transport;GO:0043406|positive regulation of MAP kinase activity;GO:0044380|protein localization to cytoskeleton;GO:0045600|positive regulation of fat cell differentiation;GO:0045821|positive regulation of glycolytic process;GO:0045907|positive regulation of vasoconstriction;GO:0048148|behavioral response to cocaine;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050965|detection of temperature stimulus involved in sensory perception of pain;GO:0050966|detection of mechanical stimulus involved in sensory perception of pain;GO:0051209|release of sequestered calcium ion into cytosol;GO:0051967|negative regulation of synaptic transmission, glutamatergic;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0098664|G protein-coupled serotonin receptor signaling pathway;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005901|caveola;GO:0030424|axon;GO:0030425|dendrite;GO:0031410|cytoplasmic vesicle;GO:0043025|neuronal cell body;GO:0043198|dendritic shaft;GO:0070852|cell body fiber;GO:0098666|G protein-coupled serotonin receptor complex;GO:0098978|glutamatergic synapse;GO:0099055|integral component of postsynaptic membrane;GO:0099056|integral component of presynaptic membrane;","GO:0001587|Gq/11-coupled serotonin receptor activity;GO:0004993|G protein-coupled serotonin receptor activity;GO:0005515|protein binding;GO:0030594|neurotransmitter receptor activity;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;GO:0051378|serotonin binding;GO:0071886|1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding;","K04157","HTR2; 5-hydroxytryptamine receptor 2"]
["ENSRNOG00000006645",137,8.813270031,275,17.75451141,0.496396089,-1.010436345,{"v":5.20799e-12,"d":"5.21E-12"},{"v":6.07029E-12,"d":"6.07E-12"},"down","yes","ENSRNOG00000006645","pseudogene","chr3:99432505-99704961:-","gi|378523729|sp|A2AGL3.1|RYR3_MOUSE",19059,0,"RecName: Full=Ryanodine receptor 3; Short=RYR-3; Short=RyR3; AltName: Full=Brain ryanodine receptor-calcium release channel; AltName: Full=Brain-type ryanodine receptor; AltName: Full=Type 3 ryanodine receptor","gi|672046727|ref|XM_008762132.1|",5354,0,"PREDICTED: Rattus norvegicus ryanodine receptor 3 (Ryr3), transcript variant X2, mRNA","A2AGL3",7346,0,"Ryanodine receptor 3",".",".",".",".","pfam06459","RR_TM4-6","Ryanodine Receptor TM 4-6. This region covers TM regions 4-6 of the ryanodine receptor 1 family.","GO:0006816|calcium ion transport;GO:0006874|cellular calcium ion homeostasis;GO:0006941|striated muscle contraction;GO:0051209|release of sequestered calcium ion into cytosol;GO:0051481|negative regulation of cytosolic calcium ion concentration;","GO:0005783|endoplasmic reticulum;GO:0005790|smooth endoplasmic reticulum;GO:0005886|plasma membrane;GO:0030018|Z disc;GO:0030314|junctional membrane complex;GO:0030659|cytoplasmic vesicle membrane;GO:0033017|sarcoplasmic reticulum membrane;GO:0034704|calcium channel complex;GO:0042383|sarcolemma;GO:0048471|perinuclear region of cytoplasm;","GO:0005219|ryanodine-sensitive calcium-release channel activity;GO:0005509|calcium ion binding;GO:0005516|calmodulin binding;GO:0015278|calcium-release channel activity;GO:0048763|calcium-induced calcium release activity;","K04963","RYR3; ryanodine receptor 3"]
["ENSRNOG00000002950",65,4.181478482,168,10.84639242,0.385517905,-1.375130229,{"v":5.58388e-12,"d":"5.58E-12"},{"v":6.49914e-12,"d":"6.50E-12"},"down","yes","Lyl1","protein_coding","chr19:23452140-23455007:-","gi|56090489|ref|NP_001007678.1|",1254,{"v":1E-168,"d":"1.00E-168"},"protein lyl-1 [Rattus norvegicus]","gi|56090488|ref|NM_001007677.1|",1459,0,"Rattus norvegicus lymphoblastic leukemia associated hematopoiesis regulator 1 (Lyl1), mRNA","Q66HH3",487,{"v":5e-170,"d":"5.00E-170"},"Protein lyl-1",".",".",".",".","pfam00010","HLH","Helix-loop-helix DNA-binding domain.","GO:0001955|blood vessel maturation;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008150|biological_process;GO:0030183|B cell differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0060216|definitive hemopoiesis;","GO:0005575|cellular_component;GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0046983|protein dimerization activity;","K15604","LYL1; protein lyl-1"]
["ENSRNOG00000001338",37,2.380226213,121,7.811985018,0.30468904,-1.714590491,{"v":6.23611e-12,"d":"6.24E-12"},{"v":7.23468E-12,"d":"7.23E-12"},"down","yes","Hpd","protein_coding","chr12:33381231-33392766:+","gi|8393557|ref|NP_058929.1|",2118,0,"4-hydroxyphenylpyruvate dioxygenase [Rattus norvegicus]","gi|51980499|gb|BC081819.1|",1336,0,"Rattus norvegicus 4-hydroxyphenylpyruvate dioxygenase, mRNA (cDNA clone MGC:93530 IMAGE:7107086), complete cds","P32755",820,0,"4-hydroxyphenylpyruvate dioxygenase","all0771",198,{"v":6E-57,"d":"6.00E-57"},"COG3185","pfam00903","Glyoxalase","Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily.","GO:0006559|L-phenylalanine catabolic process;GO:0006572|tyrosine catabolic process;","GO:0000139|Golgi membrane;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005794|Golgi apparatus;","GO:0003868|4-hydroxyphenylpyruvate dioxygenase activity;GO:0046872|metal ion binding;","K00457","HPD, hppD; 4-hydroxyphenylpyruvate dioxygenase [EC:1.13.11.27]"]
["ENSRNOG00000021256",21,1.350939202,91,5.875129229,0.22994204,-2.120657837,{"v":6.32094e-12,"d":"6.32E-12"},{"v":7.32863e-12,"d":"7.33E-12"},"down","yes","Adra1d","protein_coding","chr3:118793346-118809354:-","gi|149023351|gb|EDL80245.1|",2272,0,"adrenergic receptor, alpha 1d [Rattus norvegicus]","gi|13324695|ref|NM_024483.1|",2901,0,"Rattus norvegicus adrenoceptor alpha 1D (Adra1d), mRNA","P23944",872,0,"Alpha-1D adrenergic receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001986|negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure;GO:0001994|norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure;GO:0001996|positive regulation of heart rate by epinephrine-norepinephrine;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007267|cell-cell signaling;GO:0007568|aging;GO:0008217|regulation of blood pressure;GO:0010259|multicellular organism aging;GO:0043410|positive regulation of MAPK cascade;GO:0045907|positive regulation of vasoconstriction;GO:0060073|micturition;GO:0071875|adrenergic receptor signaling pathway;GO:0071880|adenylate cyclase-activating adrenergic receptor signaling pathway;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004937|alpha1-adrenergic receptor activity;GO:0042802|identical protein binding;","K04137","ADRA1D; adrenergic receptor alpha-1D"]
["ENSRNOG00000070134",0,0.032165219,44,2.840721825,0.011322903,-6.464612238,{"v":6.78406e-12,"d":"6.78E-12"},{"v":7.84488E-12,"d":"7.84E-12"},"down","yes","ENSRNOG00000070134","IG_V_gene","chr4:102500365-102500679:+","gi|149037293|gb|EDL91768.1|",474,{"v":6e-59,"d":"6.00E-59"},"rCG64259, partial [Rattus norvegicus]","gi|672031027|ref|XM_003753081.2|",225,{"v":7e-113,"d":"7.00E-113"},"PREDICTED: Rattus norvegicus similar to Ig variable region, light chain (RGD1565617), mRNA","P01660",163,{"v":4E-51,"d":"4.00E-51"},"Ig kappa chain V-III region PC 3741/TEPC 111",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000000956",47,3.023530595,138,8.909536632,0.339358905,-1.559116224,{"v":6.99302E-12,"d":"6.99E-12"},{"v":8.08161e-12,"d":"8.08E-12"},"down","yes","Rasl11a","protein_coding","chr12:8258159-8262576:-","gi|564378145|ref|XP_006248896.1|",1387,0,"PREDICTED: ras-like protein family member 11A isoform X1 [Rattus norvegicus]","gi|672071969|ref|XM_006248834.2|",1056,0,"PREDICTED: Rattus norvegicus RAS-like family 11 member A (Rasl11a), transcript variant X1, mRNA","Q6IMA3",441,{"v":1E-153,"d":"1.00E-153"},"Ras-like protein family member 11A",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0045943|positive regulation of transcription by RNA polymerase I;","GO:0005730|nucleolus;","GO:0003924|GTPase activity;GO:0005525|GTP binding;","K07852","RASL11A; Ras-like protein family member 11A"]
["ENSRNOG00000013465",18,1.157947887,84,5.423196211,0.213517609,-2.227573041,{"v":9.88387e-12,"d":"9.88E-12"},{"v":1.13585E-11,"d":"1.14E-11"},"down","yes","Tepp","protein_coding","chr19:9712641-9722257:-","gi|672084062|ref|XP_008770496.1|",1184,{"v":5e-157,"d":"5.00E-157"},"PREDICTED: testis, prostate and placenta-expressed protein isoform X1 [Rattus norvegicus]","gi|672084061|ref|XM_008772274.1|",910,0,"PREDICTED: Rattus norvegicus testis, prostate and placenta expressed (Tepp), transcript variant X1, mRNA","Q6IMG9",325,{"v":5e-109,"d":"5.00E-109"},"Testis, prostate and placenta-expressed protein",".",".",".",".","pfam05283","MGC-24","Multi-glycosylated core protein 24 (MGC-24). This family consists of several MGC-24 (or Cd164 antigen) proteins from eukaryotic organisms. MGC-24/CD164 is a sialomucin expressed in many normal and cancerous tissues. In humans, soluble and transmembrane forms of MGC-24 are produced by alternative splicing.","GO:0019953|sexual reproduction;",".",".",".","."]
["ENSRNOG00000050562",73,4.696121987,179,11.55657288,0.406359397,-1.299171838,{"v":9.89278e-12,"d":"9.89E-12"},{"v":1.13661e-11,"d":"1.14E-11"},"down","yes","Zfp449","protein_coding","chrX:134122636-134140924:+","gi|625192244|ref|XP_003499868.2|",2628,0,"PREDICTED: zinc finger protein 449 isoform X1 [Cricetulus griseus]","gi|672033290|ref|XM_001072386.5|",3766,0,"PREDICTED: Rattus norvegicus zinc finger protein 449 (Zfp449), transcript variant X2, mRNA","Q6P9G9",926,0,"Zinc finger protein 449",".",".",".",".","pfam02023","SCAN","SCAN domain. The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerization.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0007284|spermatogonial cell division;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837|sequence-specific double-stranded DNA binding;","K09230","SCAN; SCAN domain-containing zinc finger protein"]
["ENSRNOG00000049696",3,0.192991315,48,3.098969263,0.062275969,-4.005180619,{"v":1.04451E-11,"d":"1.04E-11"},{"v":1.19741E-11,"d":"1.20E-11"},"down","yes","Rsph4a","protein_coding","chr20:30764409-30780574:+","gi|392338416|ref|XP_003753528.1|",3035,0,"PREDICTED: radial spoke head protein 4 homolog A [Rattus norvegicus]","gi|672031791|ref|XM_003753480.3|",2339,0,"PREDICTED: Rattus norvegicus radial spoke head protein 4 homolog A (LOC103689994), mRNA","Q8BYM7",1019,0,"Radial spoke head protein 4 homolog A",".",".",".",".","pfam04712","Radial_spoke","Radial spokehead-like protein. This family includes the radial spoke head proteins RSP4 and RSP6 from Chlamydomonas reinhardtii, and several eukaryotic homologues, including mammalian RSHL1, the protein product of a familial ciliary dyskinesia candidate gene.","GO:0003341|cilium movement;GO:0035082|axoneme assembly;GO:0060294|cilium movement involved in cell motility;","GO:0001535|radial spoke head;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005929|cilium;GO:0005930|axoneme;",".","K19756","RSPH4_6; radial spoke head protein 4/6"]
["ENSRNOG00000031997",91,5.854069875,206,13.29974309,0.440164132,-1.183886506,{"v":1.12375e-11,"d":"1.12E-11"},{"v":1.28567E-11,"d":"1.29E-11"},"down","yes","Ttll7","protein_coding","chr2:235765835-235885047:+","gi|564301106|ref|XP_006224343.1|",4202,0,"PREDICTED: tubulin polyglutamylase TTLL7 isoform X1 [Rattus norvegicus]","gi|729042230|ref|NM_001302957.1|",2492,0,"Mus musculus tubulin tyrosine ligase-like family, member 7 (Ttll7), transcript variant 1, mRNA","A4Q9F0",1617,0,"Tubulin polyglutamylase TTLL7",".",".",".",".","pfam03133","TTL","Tubulin-tyrosine ligase family. Tubulins and microtubules are subjected to several post-translational modifications of which the reversible detyrosination/tyrosination of the carboxy-terminal end of most alpha-tubulins has been extensively analysed. This modification cycle involves a specific carboxypeptidase and the activity of the tubulin-tyrosine ligase (TTL). The true physiological function of TTL has so far not been established. Tubulin-tyrosine ligase (TTL) catalyses the ATP-dependent post-translational addition of a tyrosine to the carboxy terminal end of detyrosinated alpha-tubulin. In normally cycling cells, the tyrosinated form of tubulin predominates. However, in breast cancer cells, the detyrosinated form frequently predominates, with a correlation to tumor aggressiveness. On the other hand, 3-nitrotyrosine has been shown to be incorporated, by TTL, into the carboxy terminal end of detyrosinated alpha-tubulin. This reaction is not reversible by the carboxypeptidase enzyme. Cells cultured in 3-nitrotyrosine rich medium showed evidence of altered microtubule structure and function, including altered cell morphology, epithelial barrier dysfunction, and apoptosis. Bacterial homologs of TTL are predicted to form peptide tags. Some of these are fused to a 2-oxoglutarate Fe(II)-dependent dioxygenase domain.","GO:0018095|protein polyglutamylation;","GO:0036064|ciliary basal body;GO:0097731|9+0 non-motile cilium;","GO:0043014|alpha-tubulin binding;GO:0048487|beta-tubulin binding;GO:0070740|tubulin-glutamic acid ligase activity;","K16583","TTLL7; tubulin polyglutamylase TTLL7 [EC:6.3.2.62]"]
["ENSRNOG00000066431",0,0.032165219,43,2.776159965,0.011586227,-6.431445374,{"v":1.13856E-11,"d":"1.14E-11"},{"v":1.30183E-11,"d":"1.30E-11"},"down","yes","ENSRNOG00000066431","protein_coding","chr4:101564709-101565498:-","gi|148666393|gb|EDK98809.1|",431,{"v":2E-51,"d":"2.00E-51"},"mCG130744, partial [Mus musculus]","gi|7650287|gb|AF217594.1|AF217594",215,{"v":4E-107,"d":"4.00E-107"},"Rattus norvegicus clone 126.26 immunoglobulin kappa light chain variable region mRNA, partial cds","P06310",147,{"v":3e-44,"d":"3.00E-44"},"Immunoglobulin kappa variable 2-30",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000014375",30,1.929913146,107,6.908118983,0.279368834,-1.83975701,{"v":1.14236E-11,"d":"1.14E-11"},{"v":1.30591E-11,"d":"1.31E-11"},"down","yes","Adgrb2","protein_coding","chr5:142331329-142362540:+","gi|157817085|ref|NP_001101384.1|",7275,0,"brain-specific angiogenesis inhibitor 2 precursor [Rattus norvegicus]","gi|157817084|ref|NM_001107914.1|",5001,0,"Rattus norvegicus adhesion G protein-coupled receptor B2 (Adgrb2), mRNA","Q8CGM1",2786,0,"Adhesion G protein-coupled receptor B2",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0007166|cell surface receptor signaling pathway;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007422|peripheral nervous system development;GO:0016525|negative regulation of angiogenesis;GO:0033173|calcineurin-NFAT signaling cascade;GO:0051965|positive regulation of synapse assembly;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;","GO:0004930|G protein-coupled receptor activity;","K04597","ADGRB2, BAI2; adhesion G protein-coupled receptor B2"]
["ENSRNOG00000070745",5,0.321652191,53,3.421778562,0.094001463,-3.411172979,{"v":1.52304E-11,"d":"1.52E-11"},{"v":1.73036e-11,"d":"1.73E-11"},"down","yes","Tnf","protein_coding","chr20:3622011-3624629:+","gi|972853972|tpe|CTQ86160.1|",1292,{"v":2e-172,"d":"2.00E-172"},"TPA: tumor necrosis factor ligand 1f [Mus musculus]","gi|672085853|ref|XM_008772775.1|",1687,0,"PREDICTED: Rattus norvegicus tumor necrosis factor (LOC103694380), mRNA","P16599",450,{"v":7e-155,"d":"7.00E-155"},"Tumor necrosis factor",".",".",".",".","pfam00229","TNF","TNF(tumor Necrosis Factor) family.",".",".",".",".","."]
["ENSRNOG00000010843",24,1.543930516,95,6.133376667,0.251726023,-1.990073727,{"v":1.58311E-11,"d":"1.58E-11"},{"v":1.79719e-11,"d":"1.80E-11"},"down","yes","Nhlrc3","protein_coding","chr2:137530012-137534879:-","gi|149064804|gb|EDM14955.1|",559,{"v":1e-63,"d":"1.00E-63"},"rCG49974, isoform CRA_c [Rattus norvegicus]","gi|672015792|ref|XM_008775148.1|",938,0,"PREDICTED: Rattus norvegicus NHL repeat containing 3 (Nhlrc3), mRNA","Q8CCH2",214,{"v":2e-60,"d":"2.00E-60"},"NHL repeat-containing protein 3",".",".",".",".","pfam01248","Ribosomal_L7Ae","Ribosomal protein L7Ae/L30e/S12e/Gadd45 family. This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118.","GO:0000209|protein polyubiquitination;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;",".","GO:0061630|ubiquitin protein ligase activity;",".","."]
["ENSRNOG00000003781",1,0.064330438,42,2.711598106,0.023724179,-5.397498042,{"v":1.64313e-11,"d":"1.64E-11"},{"v":1.86273E-11,"d":"1.86E-11"},"down","yes","Atp10b","protein_coding","chr10:27408747-27749637:+","gi|125628644|ref|NP_795973.2|",7155,0,"probable phospholipid-transporting ATPase VB [Mus musculus]","gi|672024690|ref|XM_006220635.2|",4496,0,"PREDICTED: Rattus norvegicus ATPase, class V, type 10B (Atp10b), transcript variant X1, mRNA","O94823",2424,0,"Probable phospholipid-transporting ATPase VB",".",".",".",".","pfam13246","Hydrolase_like2","Putative hydrolase of sodium-potassium ATPase alpha subunit. This is a putative hydrolase of the sodium-potassium ATPase alpha subunit.","GO:0008150|biological_process;GO:0045332|phospholipid translocation;GO:0097212|lysosomal membrane organization;","GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:1905103|integral component of lysosomal membrane;GO:1990531|phospholipid-translocating ATPase complex;","GO:0000287|magnesium ion binding;GO:0003674|molecular_function;GO:0005524|ATP binding;","K01530","E7.6.2.1; phospholipid-translocating ATPase [EC:7.6.2.1]"]
["ENSRNOG00000023030",1,0.064330438,42,2.711598106,0.023724179,-5.397498042,{"v":1.64313e-11,"d":"1.64E-11"},{"v":1.86273E-11,"d":"1.86E-11"},"down","yes","Cd96","protein_coding","chr11:54702290-54776621:+","gi|68163543|ref|NP_001020203.1|",3022,0,"T-cell surface protein tactile precursor [Rattus norvegicus]","gi|68163542|ref|NM_001025032.1|",2053,0,"Rattus norvegicus CD96 molecule (Cd96), mRNA","Q5BK49",1172,0,"T-cell surface protein tactile",".",".",".",".","pfam08205","C2-set_2","CD80-like C2-set immunoglobulin domain. These domains belong to the immunoglobulin superfamily.","GO:0002728|negative regulation of natural killer cell cytokine production;GO:0006954|inflammatory response;GO:0007160|cell-matrix adhesion;GO:0032496|response to lipopolysaccharide;GO:0032689|negative regulation of interferon-gamma production;","GO:0005737|cytoplasm;GO:0016021|integral component of membrane;",".","K06517","CD96; CD96 antigen"]
["ENSRNOG00000053494",4,0.257321753,50,3.228092983,0.079713241,-3.649036809,{"v":1.74578E-11,"d":"1.75E-11"},{"v":1.97674e-11,"d":"1.98E-11"},"down","yes","Mcpt1l1","protein_coding","chr15:29903980-29906645:-","gi|546015|gb|AAB30269.1|",1217,{"v":1E-165,"d":"1.00E-165"},"protease 1, partial [Rattus sp.]","gi|298916395|emb|FQ219938.1|",1029,0,"Rattus norvegicus TL0ADA44YN02 mRNA sequence","P09650",473,{"v":6e-167,"d":"6.00E-167"},"Mast cell protease 1","VC1649",67.4,{"v":2e-11,"d":"2.00E-11"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;",".",".","K01329","CMA1; chymase [EC:3.4.21.39]"]
["ENSRNOG00000064875",4,0.257321753,50,3.228092983,0.079713241,-3.649036809,{"v":1.74578E-11,"d":"1.75E-11"},{"v":1.97674e-11,"d":"1.98E-11"},"down","yes","ENSRNOG00000064875","protein_coding","chr18:28314181-28314827:+","gi|157819619|ref|NP_001099706.1|",555,{"v":4e-69,"d":"4.00E-69"},"flavin reductase (NADPH) [Rattus norvegicus]","gi|298911058|emb|FQ232598.1|",219,{"v":2E-109,"d":"2.00E-109"},"Rattus norvegicus TL0AEA65YC07 mRNA sequence","Q923D2",213,{"v":2e-68,"d":"2.00E-68"},"Flavin reductase (NADPH)",".",".",".",".","pfam13460","NAD_binding_10","NADH(P)-binding.",".",".",".",".","."]
["ENSRNOG00000014373",3,0.192991315,47,3.034407404,0.06360099,-3.97480697,{"v":1.90357e-11,"d":"1.90E-11"},{"v":2.15157E-11,"d":"2.15E-11"},"down","yes","Trim66","protein_coding","chr1:163470350-163537185:-","gi|300797500|ref|NP_001178768.1|",6297,0,"tripartite motif-containing protein 66 [Rattus norvegicus]","gi|672037975|ref|XM_006229983.2|",6795,0,"PREDICTED: Rattus norvegicus tripartite motif-containing 66 (Trim66), transcript variant X1, mRNA","Q924W6",2057,0,"Tripartite motif-containing protein 66",".",".",".",".","pfam00439","Bromodomain","Bromodomain. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.","GO:0045892|negative regulation of transcription, DNA-templated;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0010369|chromocenter;GO:0016235|aggresome;","GO:0003682|chromatin binding;GO:0008270|zinc ion binding;GO:0042802|identical protein binding;","K12032","TRIM66; tripartite motif-containing protein 66"]
["ENSRNOG00000005947",0,0.032165219,42,2.711598106,0.011862089,-6.397498042,{"v":1.91489e-11,"d":"1.91E-11"},{"v":2.16351e-11,"d":"2.16E-11"},"down","yes","Pde6h","protein_coding","chr4:169857812-169872969:+","gi|149049136|gb|EDM01590.1|",421,{"v":2e-49,"d":"2.00E-49"},"phosphodiesterase 6H, cGMP-specific, cone, gamma, isoform CRA_b [Rattus norvegicus]","gi|672051307|ref|XM_006237558.2|",410,0,"PREDICTED: Rattus norvegicus phosphodiesterase 6H, cGMP-specific, cone, gamma (Pde6h), transcript variant X1, mRNA","P61250",96.3,{"v":7e-24,"d":"7.00E-24"},"Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma",".",".",".",".","pfam04868","PDE6_gamma","Retinal cGMP phosphodiesterase, gamma subunit. Retinal rod and cone cGMP phosphodiesterases function as the effector enzymes in the vertebrate visual transduction cascade. This family represents the inhibitory gamma subunit, which is also expressed outside retinal tissues and has been shown to interact with the G-protein-coupled receptor kinase 2 signalling system to regulate the epidermal growth factor- and thrombin-dependent stimulation of p42/p44 mitogen-activated protein kinase in human embryonic kidney 293 cells.","GO:0007601|visual perception;GO:0008150|biological_process;GO:0043410|positive regulation of MAPK cascade;GO:0045742|positive regulation of epidermal growth factor receptor signaling pathway;GO:0045745|positive regulation of G protein-coupled receptor signaling pathway;","GO:0005575|cellular_component;GO:0042622|photoreceptor outer segment membrane;","GO:0003674|molecular_function;GO:0030553|cGMP binding;GO:0047555|3',5'-cyclic-GMP phosphodiesterase activity;","K13760","PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma"]
["ENSRNOG00000010199",15,0.964956573,76,4.906701334,0.196660956,-2.346217537,{"v":2.3572E-11,"d":"2.36E-11"},{"v":2.65484e-11,"d":"2.65E-11"},"down","yes","Glrb","protein_coding","chr2:166134626-166207489:-","gi|17865325|ref|NP_445748.1|",2307,0,"glycine receptor subunit beta precursor [Rattus norvegicus]","gi|672042653|ref|XM_006232506.2|",3030,0,"PREDICTED: Rattus norvegicus glycine receptor, beta (Glrb), transcript variant X1, mRNA","P20781",893,0,"Glycine receptor subunit beta",".",".",".",".","pfam02931","Neur_chan_LBD","Neurotransmitter-gated ion-channel ligand binding domain. This family is the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.","GO:0001964|startle response;GO:0006811|ion transport;GO:0007165|signal transduction;GO:0007218|neuropeptide signaling pathway;GO:0007268|chemical synaptic transmission;GO:0007340|acrosome reaction;GO:0007399|nervous system development;GO:0007601|visual perception;GO:0007628|adult walking behavior;GO:0034220|ion transmembrane transport;GO:0042391|regulation of membrane potential;GO:0043200|response to amino acid;GO:0050877|nervous system process;GO:0050905|neuromuscular process;GO:0060012|synaptic transmission, glycinergic;GO:0060013|righting reflex;GO:0060079|excitatory postsynaptic potential;GO:0097112|gamma-aminobutyric acid receptor clustering;GO:1902476|chloride transmembrane transport;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016935|glycine-gated chloride channel complex;GO:0030425|dendrite;GO:0043005|neuron projection;GO:0043204|perikaryon;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0098690|glycinergic synapse;GO:0098982|GABA-ergic synapse;","GO:0004888|transmembrane signaling receptor activity;GO:0005254|chloride channel activity;GO:0005515|protein binding;GO:0016594|glycine binding;GO:0016933|extracellularly glycine-gated ion channel activity;GO:0016934|extracellularly glycine-gated chloride channel activity;GO:0030594|neurotransmitter receptor activity;GO:0044877|protein-containing complex binding;GO:1904315|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K05196","GLRB; glycine receptor beta"]
["ENSRNOG00000019365",72,4.631791549,175,11.29832544,0.409953809,-1.28646673,{"v":2.38263E-11,"d":"2.38E-11"},{"v":2.6819e-11,"d":"2.68E-11"},"down","yes","Ablim3","protein_coding","chr18:55257583-55376380:-","gi|300794625|ref|NP_001178627.1|",3333,0,"actin-binding LIM protein 3 [Rattus norvegicus]","gi|300794624|ref|NM_001191698.1|",2716,0,"Rattus norvegicus actin binding LIM protein family, member 3 (Ablim3), mRNA","Q69ZX8",1272,0,"Actin-binding LIM protein 3",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.","GO:0006351|transcription, DNA-templated;GO:0030032|lamellipodium assembly;GO:0030036|actin cytoskeleton organization;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0060271|cilium assembly;GO:1903955|positive regulation of protein targeting to mitochondrion;","GO:0001725|stress fiber;GO:0005737|cytoplasm;GO:0015629|actin cytoskeleton;GO:0030027|lamellipodium;GO:0045202|synapse;GO:0098978|glutamatergic synapse;","GO:0046872|metal ion binding;GO:0051015|actin filament binding;","K07520","ABLIM; actin-binding LIM protein"]
["ENSRNOG00000066402",40,2.573217527,123,7.941108738,0.324037564,-1.62576703,{"v":2.49572E-11,"d":"2.50E-11"},{"v":2.80476E-11,"d":"2.80E-11"},"down","yes","ENSRNOG00000066402","lncRNA","chr4:117750227-117752151:-",".",".",".",".","gi|672050142|ref|XM_008763051.1|",672,0,"PREDICTED: Rattus norvegicus sideroflexin 5 (Sfxn5), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam15422","DUF4626","Domain of unknown function (DUF4626).",".",".",".",".","."]
["ENSRNOG00000071190",24,1.543930516,94,6.068814808,0.254403959,-1.97480697,{"v":2.546e-11,"d":"2.55E-11"},{"v":2.86071e-11,"d":"2.86E-11"},"down","yes","Pspn","protein_coding","chr9:1840896-1854327:-","gi|56090552|ref|NP_001007712.1|",1745,0,"general transcription factor IIF subunit 1 [Rattus norvegicus]","gi|672063948|ref|XM_006244321.2|",1801,0,"PREDICTED: Rattus norvegicus general transcription factor IIF, polypeptide 1 (Gtf2f1), transcript variant X1, mRNA","Q6AY96",676,0,"General transcription factor IIF subunit 1",".",".",".",".","pfam05793","TFIIF_alpha","Transcription initiation factor IIF, alpha subunit (TFIIF-alpha). Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) or RNA polymerase II-associating protein 74 (RAP74) is the large subunit of transcription factor IIF (TFIIF), which is essential for accurate initiation and stimulates elongation by RNA polymerase II.",".",".",".",".","."]
["ENSRNOG00000013932",7,0.450313067,57,3.680026,0.122366817,-3.030715711,{"v":3.15922e-11,"d":"3.16E-11"},{"v":3.53928e-11,"d":"3.54E-11"},"down","yes","Rbp2","protein_coding","chr8:99079104-99104473:+","gi|344244364|gb|EGW00468.1|",729,{"v":5e-92,"d":"5.00E-92"},"Retinol-binding protein 2 [Cricetulus griseus]","gi|564365074|ref|XM_006243607.1|",725,0,"PREDICTED: Rattus norvegicus retinol binding protein 2, cellular (Rbp2), transcript variant X1, mRNA","P06768",275,{"v":5e-92,"d":"5.00E-92"},"Retinol-binding protein 2",".",".",".",".","pfam00061","Lipocalin","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.","GO:0042572|retinol metabolic process;","GO:0005829|cytosol;","GO:0016918|retinal binding;GO:0019841|retinol binding;","K14622","RBP2, CRBP2; retinol binding protein 2"]
["ENSRNOG00000022737",0,0.032165219,41,2.647036246,0.012151409,-6.362732624,{"v":3.22756e-11,"d":"3.23E-11"},{"v":3.61302e-11,"d":"3.61E-11"},"down","yes","ENSRNOG00000022737","protein_coding","chr1:185949881-186084338:+","gi|537211353|gb|ERE80679.1|",8217,0,"putative DMBT1-like protein [Cricetulus griseus]","gi|672038741|ref|XM_008759954.1|",4474,0,"PREDICTED: Rattus norvegicus similar to deleted in malignant brain tumors 1 isoform c precursor (LOC691970), transcript variant X2, mRNA","Q8BZE1",840,0,"Putative DMBT1-like protein",".",".",".",".","pfam00530","SRCR","Scavenger receptor cysteine-rich domain. These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.","GO:0006897|endocytosis;","GO:0016020|membrane;","GO:0005044|scavenger receptor activity;","K13912","DMBT1; deleted in malignant brain tumors 1 protein"]
["ENSRNOG00000017250",96,6.175722066,210,13.55799053,0.455504232,-1.134463636,{"v":3.45812E-11,"d":"3.46E-11"},{"v":3.86505e-11,"d":"3.87E-11"},"down","yes","Gmpr","protein_coding","chr17:19151815-19189621:-","gi|17105340|ref|NP_476536.1|",1763,0,"GMP reductase 1 [Rattus norvegicus]","gi|17105339|ref|NM_057188.1|",1406,0,"Rattus norvegicus guanosine monophosphate reductase (Gmpr), mRNA","Q9Z244",683,0,"GMP reductase 1","YPO3428",471,{"v":1e-162,"d":"1.00E-162"},"COG0516","pfam00478","IMPDH","IMP dehydrogenase / GMP reductase domain. This family is involved in biosynthesis of guanosine nucleotide. Members of this family contain a TIM barrel structure. In the inosine monophosphate dehydrogenases 2 CBS domains pfam00571 are inserted in the TIM barrel. This family is a member of the common phosphate binding site TIM barrel family.","GO:0006144|purine nucleobase metabolic process;GO:0006163|purine nucleotide metabolic process;GO:0009409|response to cold;","GO:1902560|GMP reductase complex;","GO:0003920|GMP reductase activity;GO:0046872|metal ion binding;","K00364","guaC, GMPR; GMP reductase [EC:1.7.1.7]"]
["ENSRNOG00000043414",3,0.192991315,46,2.969845544,0.06498362,-3.943780075,{"v":3.46977e-11,"d":"3.47E-11"},{"v":3.87656e-11,"d":"3.88E-11"},"down","yes","Fcrl5","protein_coding","chr2:172881448-172913148:+","gi|672015986|ref|XP_008773409.1|",2880,0,"PREDICTED: Fc receptor-like protein 4 isoform X1 [Rattus norvegicus]","gi|672015985|ref|XM_008775187.1|",1806,0,"PREDICTED: Rattus norvegicus Fc receptor-like 3 (Fcrl3), transcript variant X1, mRNA","Q68SN8",912,0,"Fc receptor-like protein 5",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0050859|negative regulation of B cell receptor signaling pathway;GO:0051280|negative regulation of release of sequestered calcium ion into cytosol;","GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0043235|receptor complex;",".","K06727","FCRL, IRTA, CD307; Fc receptor-like protein"]
["ENSRNOG00000060603",101,6.497374257,217,14.00992355,0.46376943,-1.108520369,{"v":3.82334e-11,"d":"3.82E-11"},{"v":4.26573e-11,"d":"4.27E-11"},"down","yes","Nhsl1","protein_coding","chr1:12956021-13187547:+","gi|293343481|ref|XP_002725495.1|",6587,0,"PREDICTED: NHS-like protein 1 isoform X3 [Rattus norvegicus]","gi|672012476|ref|XM_002725449.4|",6424,0,"PREDICTED: Rattus norvegicus NHS-like 1 (Nhsl1), transcript variant X3, mRNA","Q8CAF4",2161,0,"NHS-like protein 1",".",".",".",".","pfam15273","NHS","NHS-like. This family of proteins includes Nance-Horan syndrome protein (NHS).","GO:0030154|cell differentiation;",".",".","K24144","NHS; Nance-Horan syndrome protein and NHS-like proteins"]
["ENSRNOG00000030920",19,1.222278326,83,5.358634351,0.228095116,-2.132292537,{"v":4.52094e-11,"d":"4.52E-11"},{"v":5.02442E-11,"d":"5.02E-11"},"down","yes","Rtn4r","protein_coding","chr11:82844309-82869466:-","gi|66774157|sp|Q99M75.2|RTN4R_RAT",2166,0,"RecName: Full=Reticulon-4 receptor; AltName: Full=Nogo receptor; Short=NgR; AltName: Full=Nogo-66 receptor; Flags: Precursor","gi|672071614|ref|XM_008768839.1|",1678,0,"PREDICTED: Rattus norvegicus reticulon 4 receptor (Rtn4r), transcript variant X1, mRNA","Q99M75",838,0,"Reticulon-4 receptor","SPy1798",64.7,{"v":8e-10,"d":"8.00E-10"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0007166|cell surface receptor signaling pathway;GO:0007409|axonogenesis;GO:0007411|axon guidance;GO:0010977|negative regulation of neuron projection development;GO:0022038|corpus callosum development;GO:0023041|neuronal signal transduction;GO:0030517|negative regulation of axon extension;GO:0035025|positive regulation of Rho protein signal transduction;GO:0043547|positive regulation of GTPase activity;GO:0048681|negative regulation of axon regeneration;GO:0050771|negative regulation of axonogenesis;GO:0050919|negative chemotaxis;","GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0030426|growth cone;GO:0031362|anchored component of external side of plasma membrane;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043198|dendritic shaft;GO:0043204|perikaryon;GO:0044295|axonal growth cone;GO:0045121|membrane raft;GO:0098793|presynapse;GO:0098978|glutamatergic synapse;","GO:0005515|protein binding;GO:0008201|heparin binding;GO:0035374|chondroitin sulfate binding;GO:0038023|signaling receptor activity;GO:0038131|neuregulin receptor activity;GO:0044877|protein-containing complex binding;GO:0048495|Roundabout binding;GO:1905573|ganglioside GM1 binding;GO:1905576|ganglioside GT1b binding;","K16659","RTN4R, NGR; reticulon-4 receptor"]
["ENSRNOG00000067740",1,0.064330438,40,2.582474386,0.024910388,-5.327108714,{"v":5.15979e-11,"d":"5.16E-11"},{"v":5.71995e-11,"d":"5.72E-11"},"down","yes","ENSRNOG00000067740","protein_coding","chr4:101835336-102305141:-","gi|672045464|ref|XP_008760027.1|",807,{"v":2e-96,"d":"2.00E-96"},"PREDICTED: Ig kappa chain V-IV region-like isoform X2 [Rattus norvegicus]","gi|672045463|ref|XM_008761805.1|",1367,0,"PREDICTED: Rattus norvegicus Ig kappa chain V-IV region-like (LOC690813), transcript variant X2, mRNA","P06312",195,{"v":6e-56,"d":"6.00E-56"},"Immunoglobulin kappa variable 4-1",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000008622",9,0.578973944,61,3.938273439,0.147012124,-2.765992955,{"v":5.29883e-11,"d":"5.30E-11"},{"v":5.86952e-11,"d":"5.87E-11"},"down","yes","Creb5","protein_coding","chr4:82393730-82790325:+","gi|197386711|ref|NP_001128093.1|",2184,0,"cyclic AMP-responsive element-binding protein 5 [Rattus norvegicus]","gi|197386710|ref|NM_001134621.1|",4148,0,"Rattus norvegicus cAMP responsive element binding protein 5 (Creb5), mRNA","Q02930",715,0,"Cyclic AMP-responsive element-binding protein 5",".",".",".",".","pfam00170","bZIP_1","bZIP transcription factor. The Pfam entry includes the basic region and the leucine zipper region.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0045444|fat cell differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050872|white fat cell differentiation;GO:0060612|adipose tissue development;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0035497|cAMP response element binding;GO:0042802|identical protein binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09047","CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5"]
["ENSRNOG00000003998",13,0.836295696,70,4.519330176,0.185048594,-2.434023918,{"v":5.66424E-11,"d":"5.66E-11"},{"v":6.26335e-11,"d":"6.26E-11"},"down","yes","Sgca","protein_coding","chr10:79908738-79922813:-","gi|157823585|ref|NP_001100509.1|",1824,0,"alpha-sarcoglycan precursor [Rattus norvegicus]","gi|157823584|ref|NM_001107039.1|",1693,0,"Rattus norvegicus sarcoglycan, alpha (Sgca), mRNA","P82350",691,0,"Alpha-sarcoglycan",".",".",".",".","pfam05510","Sarcoglycan_2","Sarcoglycan alpha/epsilon. Sarcoglycans are a subcomplex of transmembrane proteins which are part of the dystrophin-glycoprotein complex. They are expressed in the skeletal, cardiac and smooth muscle. Although numerous studies have been conducted on the sarcoglycan subcomplex in skeletal and cardiac muscle, the manner of the distribution and localisation of these proteins along the nonjunctional sarcolemma is not clear. This family contains alpha and epsilon members.","GO:0014894|response to denervation involved in regulation of muscle adaptation;GO:0043403|skeletal muscle tissue regeneration;","GO:0005575|cellular_component;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0016011|dystroglycan complex;GO:0016012|sarcoglycan complex;GO:0016021|integral component of membrane;GO:0042383|sarcolemma;GO:0045121|membrane raft;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;","K12565","SGCA; alpha-sarcoglycan"]
["ENSRNOG00000027731",4,0.257321753,48,3.098969263,0.083034626,-3.59014312,{"v":5.74977e-11,"d":"5.75E-11"},{"v":6.35642e-11,"d":"6.36E-11"},"down","yes","Ubxn10","protein_coding","chr5:150950731-150959744:-","gi|149024386|gb|EDL80883.1|",1292,{"v":9e-162,"d":"9.00E-162"},"UBX domain containing 3, isoform CRA_a [Rattus norvegicus]","gi|61556920|ref|NM_001013093.1|",1650,0,"Rattus norvegicus UBX domain protein 10 (Ubxn10), mRNA","Q8BG34",437,{"v":1E-139,"d":"1.00E-139"},"UBX domain-containing protein 10",".",".",".",".","pfam00789","UBX","UBX domain. This domain is present in ubiquitin-regulatory proteins and is a general Cdc48-interacting module.","GO:0060271|cilium assembly;","GO:0005929|cilium;GO:0030992|intraciliary transport particle B;",".","K24352","UBXN10; UBX domain-containing protein 10"]
["ENSRNOG00000002139",104,6.690365571,220,14.20360912,0.471032786,-1.086100615,{"v":5.86768e-11,"d":"5.87E-11"},{"v":6.48204E-11,"d":"6.48E-11"},"down","yes","Cracd","protein_coding","chr14:31284184-31522431:-","gi|672027800|ref|XP_008763444.1|",3733,0,"PREDICTED: uncharacterized protein KIAA1211 homolog isoform X1 [Rattus norvegicus]","gi|672076057|ref|XM_008770116.1|",7035,0,"PREDICTED: Rattus norvegicus hypothetical LOC289568 (RGD1311575), transcript variant X10, mRNA",".",".",".",".",".",".",".",".","pfam15262","DUF4592","Domain of unknown function (DUF4592). This protein family is a domain of unknown function, which lies to the N-terminus of the protein. This domain family is found in eukaryotes, and is typically between 114 and 130 amino acids in length. There are two completely conserved residues (L and A) that may be functionally important. In humans, the gene that encodes this protein lies in the position, chromosome 2 open reading frame 55.","GO:0010669|epithelial structure maintenance;GO:0030277|maintenance of gastrointestinal epithelium;GO:0030838|positive regulation of actin filament polymerization;GO:2000813|negative regulation of barbed-end actin filament capping;",".",".",".","."]
["ENSRNOG00000057245",2,0.128660876,42,2.711598106,0.047448358,-4.397498042,{"v":6.79613e-11,"d":"6.80E-11"},{"v":7.48743e-11,"d":"7.49E-11"},"down","yes","Rbbp8nl","protein_coding","chr3:167364048-167379092:-","gi|672017875|ref|XP_008773863.1|",2549,0,"PREDICTED: RBBP8 N-terminal-like protein [Rattus norvegicus]","gi|672017874|ref|XM_008775641.1|",2017,0,"PREDICTED: Rattus norvegicus RBBP8 N-terminal like (Rbbp8nl), mRNA","Q8NC74",466,{"v":2e-148,"d":"2.00E-148"},"RBBP8 N-terminal-like protein",".",".",".",".","pfam10482","CtIP_N","tumor-suppressor protein CtIP N-terminal domain. CtIP is predominantly a nuclear protein that complexes with both BRCA1 and the BRCA1-associated RING domain protein (BARD1). At the protein level, CtIP expression varies with cell cycle progression in a pattern identical to that of BRCA1. Thus, the steady-state levels of CtIP polypeptides, which remain low in resting cells and G1 cycling cells, increase dramatically as Dividing cells traverse the G1/S boundary. CtIP can potentially modulate the functions ascribed to BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. This N-terminal domain carries a coiled-coil region and is essential for homodimerization of the protein. The C-terminal domain is family pfam08573.",".",".",".",".","."]
["ENSRNOG00000066201",5,0.321652191,50,3.228092983,0.099641551,-3.327108714,{"v":8.91453e-11,"d":"8.91E-11"},{"v":9.75918e-11,"d":"9.76E-11"},"down","yes","Lgi2","protein_coding","chr14:58415965-58443407:+","gi|201066369|ref|NP_001100689.2|",2639,0,"leucine-rich repeat LGI family member 2 precursor [Rattus norvegicus]","gi|201066368|ref|NM_001107219.2|",1717,0,"Rattus norvegicus leucine-rich repeat LGI family, member 2 (Lgi2), mRNA","Q1EGL1",1007,0,"Leucine-rich repeat LGI family member 2",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.",".",".",".",".","."]
["ENSRNOG00000004614",1,0.064330438,39,2.517912527,0.025549116,-5.290582838,{"v":9.16722e-11,"d":"9.17E-11"},{"v":1.00262E-10,"d":"1.00E-10"},"down","yes","Lypd6b","protein_coding","chr3:34199599-34360770:+","gi|197386527|ref|NP_001128052.1|",1078,{"v":4e-139,"d":"4.00E-139"},"ly6/PLAUR domain-containing protein 6B [Rattus norvegicus]","gi|197386526|ref|NM_001134580.1|",2326,0,"Rattus norvegicus LY6/PLAUR domain containing 6B (Lypd6b), mRNA","Q9D7F2",350,{"v":4e-114,"d":"4.00E-114"},"Ly6/PLAUR domain-containing protein 6B",".",".",".",".","pfam01064","Activin_recp","Activin types I and II receptor domain. This Pfam entry consists of both TGF-beta receptor types. This is an alignment of the hydrophilic cysteine-rich ligand-binding domains, Both receptor types, (type I and II) posses a 9 amino acid cysteine box, with the the consensus CCX{4-5}CN. The type I receptors also possess 7 extracellular residues preceding the cysteine box.",".","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0030548|acetylcholine receptor regulator activity;","K25368","LYPD6B; Ly-6/uPAR domain-containing protein 6B"]
["ENSRNOG00000070018",76,4.889113302,177,11.42744916,0.427839427,-1.224858656,{"v":1.01034e-10,"d":"1.01E-10"},{"v":1.10163E-10,"d":"1.10E-10"},"down","yes","ENSRNOG00000070018","lncRNA","chr9:103823929-103827364:-",".",".",".",".","gi|672066152|ref|XM_008767372.1|",3436,0,"PREDICTED: Rattus norvegicus fer (fps/fes related) tyrosine kinase (Fer), transcript variant X6, mRNA",".",".",".",".",".",".",".",".","pfam07090","DUF1355","Protein of unknown function (DUF1355). This family consists of several hypothetical bacterial proteins of around 250 residues in length. The function of this family is unknown. THe structure of this domain was solved by the Midwest Center for Structural Genomics (MCSG). The structure has been classified as part of the Class-I Glutamine amidotransferase superfamily.",".",".",".",".","."]
["ENSRNOG00000016684",14,0.900626135,71,4.583892036,0.196476297,-2.347572817,{"v":1.04247E-10,"d":"1.04E-10"},{"v":1.13602E-10,"d":"1.14E-10"},"down","yes","Wnk2","protein_coding","chr17:15504261-15612479:+","gi|564390773|ref|XP_006253777.1|",8636,0,"PREDICTED: serine/threonine-protein kinase WNK2 isoform X2 [Rattus norvegicus]","gi|672081305|ref|XM_006253715.2|",6656,0,"PREDICTED: Rattus norvegicus WNK lysine deficient protein kinase 2 (Wnk2), transcript variant X1, mRNA","Q3UH66",3059,0,"Serine/threonine-protein kinase WNK2",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006468|protein phosphorylation;GO:0008285|negative regulation of cell proliferation;GO:0010766|negative regulation of sodium ion transport;GO:0035556|intracellular signal transduction;GO:0046777|protein autophosphorylation;GO:0050801|ion homeostasis;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:1903288|positive regulation of potassium ion import;GO:2000651|positive regulation of sodium ion transmembrane transporter activity;","GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;GO:0019869|chloride channel inhibitor activity;GO:0019870|potassium channel inhibitor activity;","K08867","WNK, PRKWNK; WNK lysine deficient protein kinase [EC:2.7.11.1]"]
["ENSRNOG00000014452",50,3.216521909,136,8.780412913,0.366329231,-1.448787271,{"v":1.13127E-10,"d":"1.13E-10"},{"v":1.22927e-10,"d":"1.23E-10"},"down","yes","Zfhx3","protein_coding","chr19:36630254-36881771:+","gi|672085073|ref|XP_008770789.1|",13553,0,"PREDICTED: zinc finger homeobox protein 3 isoform X2 [Rattus norvegicus]","gi|672085072|ref|XM_008772567.1|",11296,0,"PREDICTED: Rattus norvegicus zinc finger homeobox 3 (Zfhx3), transcript variant X2, mRNA","Q61329",5062,0,"Zinc finger homeobox protein 3","ECU06g0500",55.1,3e-07,"COG5576","pfam00046","Homeobox","Homeobox domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007420|brain development;GO:0032922|circadian regulation of gene expression;GO:0045662|negative regulation of myoblast differentiation;GO:0045663|positive regulation of myoblast differentiation;GO:0045664|regulation of neuron differentiation;GO:0045785|positive regulation of cell adhesion;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051726|regulation of cell cycle;GO:0071559|response to transforming growth factor beta;GO:1904059|regulation of locomotor rhythm;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005737|cytoplasm;GO:0016604|nuclear body;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0008270|zinc ion binding;GO:0019899|enzyme binding;","K09378","ZFHX3, ATBF1; zinc finger homeobox protein 3"]
["ENSRNOG00000020945",3,0.192991315,44,2.840721825,0.067937421,-3.879649737,{"v":1.15329E-10,"d":"1.15E-10"},{"v":1.25224e-10,"d":"1.25E-10"},"down","yes","Ms4a1","protein_coding","chr1:207906374-207918512:-","gi|564332982|ref|XP_006231151.1|",1357,0,"PREDICTED: B-lymphocyte antigen CD20 isoform X1 [Rattus norvegicus]","gi|672039838|ref|XM_006231089.2|",1525,0,"PREDICTED: Rattus norvegicus membrane-spanning 4-domains, subfamily A, member 1 (Ms4a1), transcript variant X1, mRNA","P19437",469,{"v":1e-162,"d":"1.00E-162"},"B-lymphocyte antigen CD20",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.","GO:0002115|store-operated calcium entry;GO:0008150|biological_process;GO:0009617|response to bacterium;GO:0030183|B cell differentiation;GO:0042113|B cell activation;GO:0050853|B cell receptor signaling pathway;GO:0051262|protein tetramerization;GO:1902656|calcium ion import into cytosol;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0044853|plasma membrane raft;","GO:0005154|epidermal growth factor receptor binding;GO:0019865|immunoglobulin binding;GO:0042802|identical protein binding;","K06466","MS4A1, CD20; B-lymphocyte antigen CD20"]
["ENSRNOG00000004518",62,3.988487167,155,10.00708825,0.398566203,-1.327108714,{"v":1.19314e-10,"d":"1.19E-10"},{"v":1.29404E-10,"d":"1.29E-10"},"down","yes","Cacnb1","protein_coding","chr10:82998182-83018694:-","gi|564374414|ref|XP_006247471.1|",2786,0,"PREDICTED: voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [Rattus norvegicus]","gi|672068893|ref|XM_006247409.2|",3392,0,"PREDICTED: Rattus norvegicus calcium channel, voltage-dependent, beta 1 subunit (Cacnb1), transcript variant X1, mRNA","P54283",984,0,"Voltage-dependent L-type calcium channel subunit beta-1",".",".",".",".","pfam00625","Guanylate_kin","Guanylate kinase.","GO:0006612|protein targeting to membrane;GO:0006816|calcium ion transport;GO:0007268|chemical synaptic transmission;GO:0007528|neuromuscular junction development;GO:0034765|regulation of ion transmembrane transport;GO:0070588|calcium ion transmembrane transport;GO:1901385|regulation of voltage-gated calcium channel activity;GO:1902514|regulation of calcium ion transmembrane transport via high voltage-gated calcium channel;GO:1904646|cellular response to amyloid-beta;","GO:0005891|voltage-gated calcium channel complex;GO:0016529|sarcoplasmic reticulum;GO:0030315|T-tubule;GO:0042383|sarcolemma;GO:0098793|presynapse;GO:0098794|postsynapse;GO:0098978|glutamatergic synapse;","GO:0005245|voltage-gated calcium channel activity;GO:0005515|protein binding;GO:0008331|high voltage-gated calcium channel activity;GO:0019901|protein kinase binding;GO:0019904|protein domain specific binding;GO:0042802|identical protein binding;GO:0051219|phosphoprotein binding;","K04862","CACNB1; voltage-dependent calcium channel beta-1"]
["ENSRNOG00000020792",75,4.824782864,175,11.29832544,0.427035218,-1.227573041,{"v":1.19488E-10,"d":"1.19E-10"},{"v":1.29568e-10,"d":"1.30E-10"},"down","yes","Etv4","protein_coding","chr10:86706749-86721974:-","gi|148702120|gb|EDL34067.1|",2774,0,"ets variant gene 4 (E1A enhancer binding protein, E1AF), isoform CRA_b, partial [Mus musculus]","gi|157819374|ref|NM_001108299.1|",2329,0,"Rattus norvegicus ets variant 4 (Etv4), mRNA","P28322",938,0,"ETS translocation variant 4",".",".",".",".","pfam04621","ETS_PEA3_N","PEA3 subfamily ETS-domain transcription factor N terminal domain. The N terminus of the PEA3 transcription factors is implicated in transactivation and in inhibition of DNA binding. Transactivation is potentiated by activation of the Ras/MAP kinase and protein kinase A signalling cascades. The N terminal region contains conserved MAP kinase phosphorylation sites.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0008045|motor neuron axon guidance;GO:0010628|positive regulation of gene expression;GO:0030154|cell differentiation;GO:0033600|negative regulation of mammary gland epithelial cell proliferation;GO:0045618|positive regulation of keratinocyte differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048863|stem cell differentiation;GO:0060444|branching involved in mammary gland duct morphogenesis;","GO:0005634|nucleus;GO:0005694|chromosome;GO:0005730|nucleolus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K15592","ETV4; ets translocation variant 4"]
["ENSRNOG00000062887",6,0.385982629,52,3.357216702,0.11497102,-3.120657837,{"v":1.29042e-10,"d":"1.29E-10"},{"v":1.39557e-10,"d":"1.40E-10"},"down","yes","Gpr35","protein_coding","chr9:93527127-93539299:+","gi|564369848|ref|XP_006245599.1|",1513,0,"PREDICTED: G-protein coupled receptor 35 isoform X1 [Rattus norvegicus]","gi|672066184|ref|XM_006245537.2|",2936,0,"PREDICTED: Rattus norvegicus G protein-coupled receptor 35 (Gpr35), transcript variant X3, mRNA","Q9ES90",519,{"v":1E-172,"d":"1.00E-172"},"G-protein coupled receptor 35",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.",".",".",".",".","."]
["ENSRNOG00000002736",82,5.275095931,185,11.94394404,0.441654441,-1.179010075,{"v":1.42473E-10,"d":"1.42E-10"},{"v":1.53733E-10,"d":"1.54E-10"},"down","yes","Rabgap1l","protein_coding","chr13:72468110-73059984:-","gi|564381347|ref|XP_006250167.1|",5310,0,"PREDICTED: rab GTPase-activating protein 1-like isoform X3 [Rattus norvegicus]","gi|672074422|ref|XM_006250105.2|",4313,0,"PREDICTED: Rattus norvegicus RAB GTPase activating protein 1-like (Rabgap1l), transcript variant X2, mRNA","A6H6A9",1545,0,"Rab GTPase-activating protein 1-like",".",".",".",".","pfam00566","RabGAP-TBC","Rab-GTPase-TBC domain. Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.","GO:0006886|intracellular protein transport;GO:0032880|regulation of protein localization;GO:0090630|activation of GTPase activity;","GO:0005634|nucleus;GO:0005769|early endosome;GO:0005794|Golgi apparatus;","GO:0005096|GTPase activator activity;GO:0031267|small GTPase binding;",".","."]
["ENSRNOG00000068554",0,0.032165219,38,2.453350667,0.01311073,-6.253108133,{"v":1.56653E-10,"d":"1.57E-10"},{"v":1.68239E-10,"d":"1.68E-10"},"down","yes","ENSRNOG00000068554","protein_coding","chr11:64374347-64381901:+","gi|109493345|ref|XP_001070063.1|",516,{"v":2e-63,"d":"2.00E-63"},"PREDICTED: stefin-1-like [Rattus norvegicus]","gi|672026104|ref|XM_003752493.3|",410,0,"PREDICTED: Rattus norvegicus similar to stefin A2 (LOC689230), mRNA","P35173",144,{"v":4e-42,"d":"4.00E-42"},"Stefin-3",".",".",".",".","pfam00031","Cystatin","Cystatin domain. Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 are related to this family but have not been included.",".",".",".",".","."]
["ENSRNOG00000069560",0,0.032165219,38,2.453350667,0.01311073,-6.253108133,{"v":1.56653E-10,"d":"1.57E-10"},{"v":1.68239E-10,"d":"1.68E-10"},"down","yes","ENSRNOG00000069560","lncRNA","chr19:17946982-18006848:-","gi|148675219|gb|EDL07166.1|",270,{"v":1e-24,"d":"1.00E-24"},"mCG1028420, partial [Mus musculus]","gi|672084552|ref|XR_597180.1|",804,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102553502 (LOC102553502), transcript variant X2, ncRNA",".",".",".",".",".",".",".",".","pfam03554","Herpes_UL73","UL73 viral envelope glycoprotein. This family groups together the viral proteins BLRF1, U46, 53, and UL73. The UL73-like envelope glycoproteins, which associates in a high molecular mass complex with its counterpart, gM, induce neutralizing antibody responses in the host. These glycoprotein are highly polymorphic, particularly in the N-terminal region.",".",".",".",".","."]
["ENSRNOG00000010906",89,5.725408998,195,12.58956263,0.454774257,-1.136777502,{"v":1.6049e-10,"d":"1.60E-10"},{"v":1.72294e-10,"d":"1.72E-10"},"down","yes","Ccl5","protein_coding","chr10:68322829-68327377:-","gi|61889094|ref|NP_112378.2|",337,{"v":3e-35,"d":"3.00E-35"},"C-C motif chemokine 5 precursor [Rattus norvegicus]","gi|354800115|gb|JN964616.1|",465,0,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Ccl5:tm1a(EUCOMM)Hmgu; transgenic","P50231",130,{"v":2E-35,"d":"2.00E-35"},"C-C motif chemokine 5",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0000165|MAPK cascade;GO:0002544|chronic inflammatory response;GO:0002548|monocyte chemotaxis;GO:0006468|protein phosphorylation;GO:0006816|calcium ion transport;GO:0006874|cellular calcium ion homeostasis;GO:0006887|exocytosis;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007159|leukocyte cell-cell adhesion;GO:0007165|signal transduction;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007267|cell-cell signaling;GO:0007568|aging;GO:0009410|response to xenobiotic stimulus;GO:0009615|response to virus;GO:0009617|response to bacterium;GO:0009636|response to toxic substance;GO:0009651|response to salt stress;GO:0010628|positive regulation of gene expression;GO:0010759|positive regulation of macrophage chemotaxis;GO:0010820|positive regulation of T cell chemotaxis;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0014070|response to organic cyclic compound;GO:0014823|response to activity;GO:0014911|positive regulation of smooth muscle cell migration;GO:0018894|dibenzo-p-dioxin metabolic process;GO:0030335|positive regulation of cell migration;GO:0030593|neutrophil chemotaxis;GO:0031269|pseudopodium assembly;GO:0031328|positive regulation of cellular biosynthetic process;GO:0031584|activation of phospholipase D activity;GO:0031622|positive regulation of fever generation;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0031667|response to nutrient levels;GO:0032496|response to lipopolysaccharide;GO:0032868|response to insulin;GO:0033634|positive regulation of cell-cell adhesion mediated by integrin;GO:0034097|response to cytokine;GO:0034112|positive regulation of homotypic cell-cell adhesion;GO:0034341|response to interferon-gamma;GO:0034612|response to tumor necrosis factor;GO:0035688|T-helper 1 cell diapedesis;GO:0042102|positive regulation of T cell proliferation;GO:0042119|neutrophil activation;GO:0042327|positive regulation of phosphorylation;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0043491|protein kinase B signaling;GO:0043547|positive regulation of GTPase activity;GO:0043627|response to estrogen;GO:0043922|negative regulation by host of viral transcription;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0045071|negative regulation of viral genome replication;GO:0045666|positive regulation of neuron differentiation;GO:0045672|positive regulation of osteoclast differentiation;GO:0045744|negative regulation of G protein-coupled receptor signaling pathway;GO:0045766|positive regulation of angiogenesis;GO:0045785|positive regulation of cell adhesion;GO:0048245|eosinophil chemotaxis;GO:0048247|lymphocyte chemotaxis;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0050679|positive regulation of epithelial cell proliferation;GO:0050796|regulation of insulin secretion;GO:0050863|regulation of T cell activation;GO:0050918|positive chemotaxis;GO:0051384|response to glucocorticoid;GO:0051928|positive regulation of calcium ion transport;GO:0060326|cell chemotaxis;GO:0060548|negative regulation of cell death;GO:0060754|positive regulation of mast cell chemotaxis;GO:0061098|positive regulation of protein tyrosine kinase activity;GO:0070098|chemokine-mediated signaling pathway;GO:0070100|negative regulation of chemokine-mediated signaling pathway;GO:0070233|negative regulation of T cell apoptotic process;GO:0070234|positive regulation of T cell apoptotic process;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070723|response to cholesterol;GO:0071222|cellular response to lipopolysaccharide;GO:0071230|cellular response to amino acid stimulus;GO:0071307|cellular response to vitamin K;GO:0071315|cellular response to morphine;GO:0071345|cellular response to cytokine stimulus;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071361|cellular response to ethanol;GO:0071396|cellular response to lipid;GO:0071403|cellular response to high density lipoprotein particle stimulus;GO:0071407|cellular response to organic cyclic compound;GO:0071448|cellular response to alkyl hydroperoxide;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0090026|positive regulation of monocyte chemotaxis;GO:0097305|response to alcohol;GO:0098586|cellular response to virus;GO:1901214|regulation of neuron death;GO:1901215|negative regulation of neuron death;GO:2000110|negative regulation of macrophage apoptotic process;GO:2000406|positive regulation of T cell migration;GO:2000503|positive regulation of natural killer cell chemotaxis;","GO:0005615|extracellular space;GO:0005737|cytoplasm;","GO:0004435|phosphatidylinositol phospholipase C activity;GO:0004672|protein kinase activity;GO:0008009|chemokine activity;GO:0008201|heparin binding;GO:0016004|phospholipase activator activity;GO:0030298|receptor signaling protein tyrosine kinase activator activity;GO:0031726|CCR1 chemokine receptor binding;GO:0031730|CCR5 chemokine receptor binding;GO:0042056|chemoattractant activity;GO:0042379|chemokine receptor binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0043621|protein self-association;GO:0046817|chemokine receptor antagonist activity;GO:0048020|CCR chemokine receptor binding;","K12499","CCL5; C-C motif chemokine 5"]
["ENSRNOG00000069878",9,0.578973944,59,3.80914972,0.151995586,-2.717898667,{"v":1.60896E-10,"d":"1.61E-10"},{"v":1.72698e-10,"d":"1.73E-10"},"down","yes","ENSRNOG00000069878","protein_coding","chr13:85977035-85994718:-","gi|755496152|ref|XP_011237197.1|",1914,0,"PREDICTED: LOW QUALITY PROTEIN: gamma-interferon-inducible protein 16-like [Mus musculus]","gi|298891459|emb|FQ227444.1|",950,0,"Rattus norvegicus TL0AEA13YF07 mRNA sequence","P0DOV2",353,{"v":1E-107,"d":"1.00E-107"},"Interferon-activable protein 204",".",".",".",".","pfam02760","HIN","HIN-200/IF120x domain. This domain has no know function. It is found in one or two copies per protein, and is found associated with the PAAD/DAPIN domain pfam02758.",".",".",".",".","."]
["ENSRNOG00000009649",1,0.064330438,38,2.453350667,0.026221461,-5.253108133,{"v":1.63157e-10,"d":"1.63E-10"},{"v":1.74994e-10,"d":"1.75E-10"},"down","yes","Slitrk5","protein_coding","chr15:88847535-88856836:+","gi|564387437|ref|XP_006252506.1|",4063,0,"PREDICTED: SLIT and NTRK-like protein 5 isoform X2 [Rattus norvegicus]","gi|672079027|ref|XM_006252445.2|",5197,0,"PREDICTED: Rattus norvegicus SLIT and NTRK-like family, member 5 (Slitrk5), transcript variant X2, mRNA","Q810B7",1542,0,"SLIT and NTRK-like protein 5",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.","GO:0007268|chemical synaptic transmission;GO:0007409|axonogenesis;GO:0007625|grooming behavior;GO:0009410|response to xenobiotic stimulus;GO:0021756|striatum development;GO:0030534|adult behavior;GO:0043588|skin development;GO:0048813|dendrite morphogenesis;GO:0051965|positive regulation of synapse assembly;GO:0072359|circulatory system development;GO:1905606|regulation of presynapse assembly;","GO:0016021|integral component of membrane;GO:0043235|receptor complex;GO:0045202|synapse;",".",".","."]
["ENSRNOG00000026387",7,0.450313067,54,3.486340421,0.129164973,-2.952713199,{"v":1.75656e-10,"d":"1.76E-10"},{"v":1.88046E-10,"d":"1.88E-10"},"down","yes","Ms4a12","protein_coding","chr1:207882333-207893938:-","gi|564298855|ref|XP_006223705.1|",1590,0,"PREDICTED: membrane-spanning 4-domains subfamily A member 12 isoform X1 [Rattus norvegicus]","gi|672014671|ref|XM_006223643.2|",971,0,"PREDICTED: Rattus norvegicus membrane-spanning 4-domains, subfamily A, member 12 (Ms4a12), transcript variant X1, mRNA","Q9NXJ0",246,{"v":3e-77,"d":"3.00E-77"},"Membrane-spanning 4-domains subfamily A member 12",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.",".","GO:0016021|integral component of membrane;",".","K22190","MS4A3S; membrane-spanning 4-domains subfamily A member 3/4/8/12/15/18"]
["ENSRNOG00000019142",65,4.181478482,158,10.20077383,0.409917772,-1.286593555,{"v":2.1794E-10,"d":"2.18E-10"},{"v":2.32311e-10,"d":"2.32E-10"},"down","yes","Fas","protein_coding","chr1:231798960-231832591:+","gi|59624977|ref|NP_631933.2|",1602,0,"tumor necrosis factor receptor superfamily member 6 precursor [Rattus norvegicus]","gi|59624976|ref|NM_139194.2|",2541,0,"Rattus norvegicus Fas cell surface death receptor (Fas), mRNA","Q63199",619,0,"Tumor necrosis factor receptor superfamily member 6",".",".",".",".","pfam00531","Death","Death domain.","GO:0001552|ovarian follicle atresia;GO:0001666|response to hypoxia;GO:0001934|positive regulation of protein phosphorylation;GO:0006915|apoptotic process;GO:0006924|activation-induced cell death of T cells;GO:0006925|inflammatory cell apoptotic process;GO:0006955|immune response;GO:0007165|signal transduction;GO:0007283|spermatogenesis;GO:0007568|aging;GO:0007623|circadian rhythm;GO:0008625|extrinsic apoptotic signaling pathway via death domain receptors;GO:0009410|response to xenobiotic stimulus;GO:0009636|response to toxic substance;GO:0010035|response to inorganic substance;GO:0010467|gene expression;GO:0010468|regulation of gene expression;GO:0010626|negative regulation of Schwann cell proliferation;GO:0010876|lipid localization;GO:0010883|regulation of lipid storage;GO:0010942|positive regulation of cell death;GO:0014070|response to organic cyclic compound;GO:0019724|B cell mediated immunity;GO:0021537|telencephalon development;GO:0031104|dendrite regeneration;GO:0031334|positive regulation of protein complex assembly;GO:0031667|response to nutrient levels;GO:0032496|response to lipopolysaccharide;GO:0032872|regulation of stress-activated MAPK cascade;GO:0033209|tumor necrosis factor-mediated signaling pathway;GO:0034097|response to cytokine;GO:0034198|cellular response to amino acid starvation;GO:0036337|Fas signaling pathway;GO:0042127|regulation of cell proliferation;GO:0042698|ovulation cycle;GO:0042981|regulation of apoptotic process;GO:0043009|chordate embryonic development;GO:0043029|T cell homeostasis;GO:0043065|positive regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0043280|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043434|response to peptide hormone;GO:0043525|positive regulation of neuron apoptotic process;GO:0043627|response to estrogen;GO:0045060|negative thymic T cell selection;GO:0045471|response to ethanol;GO:0045619|regulation of lymphocyte differentiation;GO:0045637|regulation of myeloid cell differentiation;GO:0046898|response to cycloheximide;GO:0048536|spleen development;GO:0050869|negative regulation of B cell activation;GO:0051384|response to glucocorticoid;GO:0051402|neuron apoptotic process;GO:0060135|maternal process involved in female pregnancy;GO:0070227|lymphocyte apoptotic process;GO:0070301|cellular response to hydrogen peroxide;GO:0070848|response to growth factor;GO:0071234|cellular response to phenylalanine;GO:0071260|cellular response to mechanical stimulus;GO:0071279|cellular response to cobalt ion;GO:0071285|cellular response to lithium ion;GO:0071333|cellular response to glucose stimulus;GO:0071345|cellular response to cytokine stimulus;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071391|cellular response to estrogen stimulus;GO:0071407|cellular response to organic cyclic compound;GO:0071455|cellular response to hyperoxia;GO:0071456|cellular response to hypoxia;GO:0071464|cellular response to hydrostatic pressure;GO:0097049|motor neuron apoptotic process;GO:0097190|apoptotic signaling pathway;GO:0097191|extrinsic apoptotic signaling pathway;GO:0097192|extrinsic apoptotic signaling pathway in absence of ligand;GO:0097284|hepatocyte apoptotic process;GO:0097421|liver regeneration;GO:0097527|necroptotic signaling pathway;GO:1900148|negative regulation of Schwann cell migration;GO:1902617|response to fluoride;GO:2001235|positive regulation of apoptotic signaling pathway;GO:2001269|positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0016604|nuclear body;GO:0030141|secretory granule;GO:0031264|death-inducing signaling complex;GO:0031265|CD95 death-inducing signaling complex;GO:0042383|sarcolemma;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0045121|membrane raft;GO:0048471|perinuclear region of cytoplasm;GO:0097440|apical dendrite;","GO:0002020|protease binding;GO:0004888|transmembrane signaling receptor activity;GO:0005031|tumor necrosis factor-activated receptor activity;GO:0005515|protein binding;GO:0005516|calmodulin binding;GO:0019900|kinase binding;GO:0038023|signaling receptor activity;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;","K04390","TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6"]
["ENSRNOG00000022176",2,0.128660876,40,2.582474386,0.049820775,-4.327108714,{"v":2.25621E-10,"d":"2.26E-10"},{"v":2.40409e-10,"d":"2.40E-10"},"down","yes","Gpr75","protein_coding","chr14:104611089-104620370:+","gi|157819133|ref|NP_001102566.1|",2615,0,"probable G-protein coupled receptor 75 [Rattus norvegicus]","gi|672077328|ref|XM_006251616.2|",2722,0,"PREDICTED: Rattus norvegicus G protein-coupled receptor 75 (Gpr75), transcript variant X1, mRNA","Q6X632",992,0,"Probable G-protein coupled receptor 75",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0070098|chemokine-mediated signaling pathway;GO:1901214|regulation of neuron death;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0016493|C-C chemokine receptor activity;","K08417","GPR75; G protein-coupled receptor 75"]
["ENSRNOG00000015615",73,4.696121987,170,10.97551614,0.427872542,-1.224746997,{"v":2.36108e-10,"d":"2.36E-10"},{"v":2.51161E-10,"d":"2.51E-10"},"down","yes","Tnfrsf11a","protein_coding","chr13:21928408-21986695:+","gi|403420622|ref|NP_001258164.1|",2789,0,"tumor necrosis factor receptor superfamily member 11A precursor [Rattus norvegicus]","gi|403420621|ref|NM_001271235.1|",2718,0,"Rattus norvegicus tumor necrosis factor receptor superfamily member 11a (Tnfrsf11a), mRNA","O35305",952,0,"Tumor necrosis factor receptor superfamily member 11A",".",".",".",".","pfam00020","TNFR_c6","TNFR/NGFR cysteine-rich region.","GO:0001503|ossification;GO:0002250|adaptive immune response;GO:0009314|response to radiation;GO:0030316|osteoclast differentiation;GO:0032496|response to lipopolysaccharide;GO:0033209|tumor necrosis factor-mediated signaling pathway;GO:0034097|response to cytokine;GO:0034612|response to tumor necrosis factor;GO:0043507|positive regulation of JUN kinase activity;GO:0045780|positive regulation of bone resorption;GO:0048535|lymph node development;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0060086|circadian temperature homeostasis;GO:0060749|mammary gland alveolus development;GO:0070555|response to interleukin-1;GO:0071812|positive regulation of fever generation by positive regulation of prostaglandin secretion;GO:0071847|TNFSF11-mediated signaling pathway;GO:0071848|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling;GO:0072674|multinuclear osteoclast differentiation;","GO:0005575|cellular_component;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0004888|transmembrane signaling receptor activity;GO:0005031|tumor necrosis factor-activated receptor activity;GO:0019955|cytokine binding;","K05147","TNFRSF11A, RANK, CD265; tumor necrosis factor receptor superfamily member 11A"]
["ENSRNOG00000012932",25,1.608260955,91,5.875129229,0.273740524,-1.86911907,{"v":2.50069e-10,"d":"2.50E-10"},{"v":2.65765e-10,"d":"2.66E-10"},"down","yes","Ccdc146","protein_coding","chr4:13662766-13811608:+","gi|68163517|ref|NP_001020215.1|",4220,0,"coiled-coil domain-containing protein 146 [Rattus norvegicus]","gi|68163516|ref|NM_001025044.1|",3366,0,"Rattus norvegicus coiled-coil domain containing 146 (Ccdc146), mRNA","Q66H60",1630,0,"Coiled-coil domain-containing protein 146",".",".",".",".","pfam02463","SMC_N","RecF/RecN/SMC N terminal domain. This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics.   This family also includes the RecF and RecN proteins that are involved in DNA metabolizm and recombination.",".",".",".",".","."]
["ENSRNOG00000063284",0,0.032165219,37,2.388788807,0.013465074,-6.214633985,{"v":2.66477e-10,"d":"2.66E-10"},{"v":2.82677e-10,"d":"2.83E-10"},"down","yes","ENSRNOG00000063284","protein_coding","chr12:18222886-18245757:+","gi|672026622|ref|XP_008757604.1|",1052,{"v":7e-129,"d":"7.00E-129"},"PREDICTED: paired immunoglobulin-like type 2 receptor beta [Rattus norvegicus]","gi|672072528|ref|XM_008769099.1|",714,0,"PREDICTED: Rattus norvegicus similar to cell surface receptor FDFACT (RGD1560281), mRNA","Q2YFS2",273,{"v":7e-82,"d":"7.00E-82"},"Paired immunoglobulin-like type 2 receptor beta",".",".",".",".","pfam05938","Self-incomp_S1","Plant self-incompatibility protein S1. This family consists of a series of plant proteins which are related to the Papaver rhoeas S1 self-incompatibility protein. Self incompatibility (SI) is the single most important outbreeding device found in angiosperms and is a mechanism that regulates the acceptance or rejection of pollen. S1 is known to exhibit specific pollen-inhibitory properties.",".",".",".",".","."]
["ENSRNOG00000032085",13,0.836295696,67,4.325644597,0.193334352,-2.370830092,{"v":2.74182e-10,"d":"2.74E-10"},{"v":2.90688e-10,"d":"2.91E-10"},"down","yes","Dlec1","protein_coding","chr8:118826466-118873655:+","gi|564310825|ref|XP_006226675.1|",8962,0,"PREDICTED: deleted in lung and esophageal cancer protein 1 homolog isoform X3 [Rattus norvegicus]","gi|672023440|ref|XM_006226613.2|",5504,0,"PREDICTED: Rattus norvegicus deleted in lung and esophageal cancer 1 (Dlec1), transcript variant X3, mRNA","Q9Y238",2361,0,"Deleted in lung and esophageal cancer protein 1",".",".",".",".","pfam02803","Thiolase_C","Thiolase, C-terminal domain. Thiolase is reported to be structurally related to beta-ketoacyl synthase (pfam00109), and also chalcone synthase.","GO:0002357|defense response to tumor cell;GO:0007283|spermatogenesis;GO:0008150|biological_process;GO:0008285|negative regulation of cell proliferation;GO:0030154|cell differentiation;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0003674|molecular_function;GO:0043014|alpha-tubulin binding;GO:0048487|beta-tubulin binding;","K25548","DLEC1; deleted in lung and esophageal cancer protein 1"]
["ENSRNOG00000066155",23,1.479600078,87,5.61688179,0.263420192,-1.924562159,{"v":2.80986E-10,"d":"2.81E-10"},{"v":2.9757e-10,"d":"2.98E-10"},"down","yes","ENSRNOG00000066155","lncRNA","chr1:221567754-221569491:-",".",".",".",".","gi|672040017|ref|XM_006231185.2|",1738,0,"PREDICTED: Rattus norvegicus amyloid beta (A4) precursor protein-binding, family A, member 1 (Apba1), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.",".",".",".",".","."]
["ENSRNOG00000011000",1,0.064330438,37,2.388788807,0.026930149,-5.214633985,{"v":2.90905e-10,"d":"2.91E-10"},{"v":3.07733e-10,"d":"3.08E-10"},"down","yes","Rims1","protein_coding","chr9:24698854-25196631:-","gi|148682448|gb|EDL14395.1|",6050,0,"regulating synaptic membrane exocytosis 1 [Mus musculus]","gi|672064620|ref|XM_008766936.1|",2796,0,"PREDICTED: Rattus norvegicus regulating synaptic membrane exocytosis 1 (Rims1), transcript variant X1, mRNA","Q9JIR4",1744,0,"Regulating synaptic membrane exocytosis protein 1",".",".",".",".","pfam00168","C2","C2 domain.","GO:0006836|neurotransmitter transport;GO:0006886|intracellular protein transport;GO:0006887|exocytosis;GO:0007269|neurotransmitter secretion;GO:0010628|positive regulation of gene expression;GO:0010808|positive regulation of synaptic vesicle priming;GO:0016081|synaptic vesicle docking;GO:0016082|synaptic vesicle priming;GO:0030154|cell differentiation;GO:0031632|positive regulation of synaptic vesicle fusion to presynaptic active zone membrane;GO:0042391|regulation of membrane potential;GO:0048167|regulation of synaptic plasticity;GO:0048169|regulation of long-term neuronal synaptic plasticity;GO:0048790|maintenance of presynaptic active zone structure;GO:0048791|calcium ion-regulated exocytosis of neurotransmitter;GO:0050806|positive regulation of synaptic transmission;GO:0060291|long-term synaptic potentiation;GO:0060478|acrosomal vesicle exocytosis;GO:0061669|spontaneous neurotransmitter secretion;GO:0065003|protein-containing complex assembly;GO:0097151|positive regulation of inhibitory postsynaptic potential;GO:1903861|positive regulation of dendrite extension;GO:2000463|positive regulation of excitatory postsynaptic potential;","GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0031982|vesicle;GO:0042734|presynaptic membrane;GO:0042995|cell projection;GO:0045202|synapse;GO:0048788|cytoskeleton of presynaptic active zone;GO:0060077|inhibitory synapse;GO:0098831|presynaptic active zone cytoplasmic component;GO:0098978|glutamatergic synapse;GO:0098982|GABA-ergic synapse;","GO:0005515|protein binding;GO:0017124|SH3 domain binding;GO:0019901|protein kinase binding;GO:0031267|small GTPase binding;GO:0044325|ion channel binding;GO:0046872|metal ion binding;GO:0098882|structural constituent of presynaptic active zone;","K15291","RIMS1, RIM1; regulating synaptic membrane exocytosis protein 1"]
["ENSRNOG00000005018",20,1.286608764,81,5.229510632,0.24602852,-2.023102527,{"v":3.15771e-10,"d":"3.16E-10"},{"v":3.33234e-10,"d":"3.33E-10"},"down","yes","Scn2a","protein_coding","chr3:50302877-50437214:+","gi|149022132|gb|EDL79026.1|",9263,0,"rCG26977, isoform CRA_a [Rattus norvegicus]","gi|6981505|ref|NM_012647.1|",8427,0,"Rattus norvegicus sodium voltage-gated channel alpha subunit 2 (Scn2a), mRNA","P04775",3568,0,"Sodium channel protein type 2 subunit alpha",".",".",".",".","pfam06512","Na_trans_assoc","Sodium ion transport-associated. Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.","GO:0006814|sodium ion transport;GO:0007399|nervous system development;GO:0007613|memory;GO:0008627|intrinsic apoptotic signaling pathway in response to osmotic stress;GO:0019228|neuronal action potential;GO:0034765|regulation of ion transmembrane transport;GO:0035725|sodium ion transmembrane transport;GO:0042552|myelination;GO:0051402|neuron apoptotic process;GO:0071456|cellular response to hypoxia;GO:0086010|membrane depolarization during action potential;GO:0099505|regulation of presynaptic membrane potential;","GO:0001518|voltage-gated sodium channel complex;GO:0005886|plasma membrane;GO:0014704|intercalated disc;GO:0016020|membrane;GO:0030315|T-tubule;GO:0030424|axon;GO:0031226|intrinsic component of plasma membrane;GO:0033268|node of Ranvier;GO:0033270|paranode region of axon;GO:0034706|sodium channel complex;GO:0043005|neuron projection;GO:0043194|axon initial segment;GO:0098978|glutamatergic synapse;GO:0099056|integral component of presynaptic membrane;","GO:0005244|voltage-gated ion channel activity;GO:0005248|voltage-gated sodium channel activity;GO:0005515|protein binding;GO:0031402|sodium ion binding;GO:0043522|leucine zipper domain binding;GO:0099508|voltage-gated ion channel activity involved in regulation of presynaptic membrane potential;","K04834","SCN2A, NAV1.2; voltage-gated sodium channel type II alpha"]
["ENSRNOG00000016854",58,3.731165415,146,9.42603151,0.395836298,-1.337024183,{"v":3.25077E-10,"d":"3.25E-10"},{"v":3.42359e-10,"d":"3.42E-10"},"down","yes","Lrrc36","protein_coding","chr19:33292074-33360141:+","gi|282847351|ref|NP_001004088.3|",2644,0,"leucine-rich repeat-containing protein 36 [Rattus norvegicus]","gi|226192806|gb|AC116220.6|",3331,0,"Rattus norvegicus CH230-256P17 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q3V0M2",917,0,"Leucine-rich repeat-containing protein 36",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.",".",".",".","K16594","LRRC36; leucine-rich repeat-containing protein 36"]
["ENSRNOG00000009260",53,3.409513224,138,8.909536632,0.382681318,-1.385784622,{"v":3.35849e-10,"d":"3.36E-10"},{"v":3.53248e-10,"d":"3.53E-10"},"down","yes","Cnr2","protein_coding","chr5:148125604-148151548:+","gi|255918134|ref|NP_001157614.1|",1833,0,"cannabinoid receptor 2 isoform 1 [Rattus norvegicus]","gi|694872628|ref|NM_001164143.3|",3300,0,"Rattus norvegicus cannabinoid receptor 2 (Cnr2), transcript variant 1, mRNA","Q9QZN9",710,0,"Cannabinoid receptor 2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001975|response to amphetamine;GO:0006954|inflammatory response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0019222|regulation of metabolic process;GO:0019233|sensory perception of pain;GO:0030595|leukocyte chemotaxis;GO:0032229|negative regulation of synaptic transmission, GABAergic;GO:0032496|response to lipopolysaccharide;GO:0033004|negative regulation of mast cell activation;GO:0038171|cannabinoid signaling pathway;GO:0045759|negative regulation of action potential;GO:0050728|negative regulation of inflammatory response;GO:0051001|negative regulation of nitric-oxide synthase activity;","GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043204|perikaryon;","GO:0004930|G protein-coupled receptor activity;GO:0004949|cannabinoid receptor activity;","K04278","CNR2; cannabinoid receptor 2"]
["ENSRNOG00000015297",4,0.257321753,45,2.905283684,0.088570267,-3.497033716,{"v":3.42713e-10,"d":"3.43E-10"},{"v":3.60335e-10,"d":"3.60E-10"},"down","yes","RGD1561662","protein_coding","chr9:13525395-13561585:-","gi|564367294|ref|XP_006244562.1|",4149,0,"PREDICTED: uncharacterized protein C6orf132 homolog isoform X2 [Rattus norvegicus]","gi|672064477|ref|XM_006244500.2|",4071,0,"PREDICTED: Rattus norvegicus similar to AI661453 protein (RGD1561662), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam03154","Atrophin-1","Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.",".",".",".",".","."]
["ENSRNOG00000048898",3,0.192991315,42,2.711598106,0.071172536,-3.812535541,{"v":3.83444E-10,"d":"3.83E-10"},{"v":4.02272e-10,"d":"4.02E-10"},"down","yes","Wasf3","protein_coding","chr12:8562062-8660751:-","gi|109496483|ref|XP_001061259.1|",2188,0,"PREDICTED: wiskott-Aldrich syndrome protein family member 3 isoform X1 [Rattus norvegicus]","gi|672026484|ref|XM_006221252.2|",2110,0,"PREDICTED: Rattus norvegicus WAS protein family, member 3 (Wasf3), transcript variant X1, mRNA","Q8VHI6",800,0,"Wiskott-Aldrich syndrome protein family member 3",".",".",".",".","pfam02205","WH2","WH2 motif. The WH2 motif (for Wiskott Aldrich syndrome homology region 2) has been shown in WASP and Scar1 (mammalian homologue) to be the region that interacts with actin.","GO:0007010|cytoskeleton organization;GO:0008360|regulation of cell shape;GO:0014003|oligodendrocyte development;GO:0030032|lamellipodium assembly;GO:0030036|actin cytoskeleton organization;GO:0031643|positive regulation of myelination;GO:0098885|modification of postsynaptic actin cytoskeleton;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0030027|lamellipodium;GO:0098794|postsynapse;GO:0098978|glutamatergic synapse;","GO:0003779|actin binding;","K06083","WASF3; WAS protein family, member 3"]
["ENSRNOG00000019220",59,3.795495853,147,9.490593369,0.399921871,-1.322209915,{"v":4.00182e-10,"d":"4.00E-10"},{"v":4.19574e-10,"d":"4.20E-10"},"down","yes","Rhod","protein_coding","chr1:201708699-201722632:-","gi|157821527|ref|NP_001099793.1|",834,{"v":8e-106,"d":"8.00E-106"},"rho-related GTP-binding protein RhoD [Rattus norvegicus]","gi|157821526|ref|NM_001106323.1|",1266,0,"Rattus norvegicus ras homolog family member D (Rhod), mRNA","P97348",312,{"v":5e-102,"d":"5.00E-102"},"Rho-related GTP-binding protein RhoD",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0006605|protein targeting;GO:0007015|actin filament organization;GO:0007163|establishment or maintenance of cell polarity;GO:0007264|small GTPase mediated signal transduction;GO:0008150|biological_process;GO:0008360|regulation of cell shape;GO:0016477|cell migration;GO:0030032|lamellipodium assembly;GO:0030335|positive regulation of cell migration;GO:0030865|cortical cytoskeleton organization;GO:0032956|regulation of actin cytoskeleton organization;GO:0045785|positive regulation of cell adhesion;GO:0048041|focal adhesion assembly;GO:0051017|actin filament bundle assembly;GO:0051893|regulation of focal adhesion assembly;GO:2000249|regulation of actin cytoskeleton reorganization;","GO:0005575|cellular_component;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0005938|cell cortex;GO:0031410|cytoplasmic vesicle;GO:0042995|cell projection;","GO:0003674|molecular_function;GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0019901|protein kinase binding;","K07530","RHOD; Ras homolog gene family, member D"]
["ENSRNOG00000028805",29,1.865582707,97,6.262500387,0.29789742,-1.747112466,{"v":4.4813e-10,"d":"4.48E-10"},{"v":4.68756e-10,"d":"4.69E-10"},"down","yes","Cfap77","protein_coding","chr3:12258453-12381319:-","gi|189011616|ref|NP_001121035.1|",1520,0,"uncharacterized protein C9orf171 homolog [Rattus norvegicus]","gi|189011615|ref|NM_001127563.1|",1707,0,"Rattus norvegicus cilia and flagella associated protein 77 (Cfap77), mRNA","Q6ZQR2",491,{"v":1E-169,"d":"1.00E-169"},"Cilia- and flagella-associated protein 77",".",".",".",".","pfam14825","DUF4483","Domain of unknown function (DUF4483). This family of proteins is found in eukaryotes. Proteins in this family are typically between 203 and 326 amino acids in length. There is a single completely conserved residue N that may be functionally important.",".",".",".",".","."]
["ENSRNOG00000018486",15,0.964956573,70,4.519330176,0.213517609,-2.227573041,{"v":5.13274e-10,"d":"5.13E-10"},{"v":5.35819e-10,"d":"5.36E-10"},"down","yes","RGD1311084","protein_coding","chr3:14080744-14086978:-","gi|155369311|ref|NP_001094449.1|",1635,0,"uncharacterized protein C9orf50 homolog [Rattus norvegicus]","gi|155369310|ref|NM_001100979.1|",1510,0,"Rattus norvegicus similar to 1700113K14Rik protein (RGD1311084), mRNA",".",".",".",".",".",".",".",".","pfam05749","Rubella_E2","Rubella membrane glycoprotein E2. Rubella virus (RV), the sole member of the genus Rubivirus within the family Togaviridae, is a small enveloped, positive strand RNA virus. The nucleocapsid consists of 40S genomic RNA and a single species of capsid protein which is enveloped within a host-derived lipid bilayer containing two viral glycoproteins, E1 (58 kDa) and E2 (42-46 kDa). In virus infected cells, RV matures by budding either at the plasma membrane, or at the internal membranes depending on the cell type and enters adjacent uninfected cells by a membrane fusion process in the endosome, directed by E1-E2 heterodimers. The heterodimer formation is crucial for E1 transport out of the endoplasmic reticulum to the Golgi and plasma membrane. In RV E1, a cysteine at position 82 is crucial for the E1-E2 heterodimer formation and cell surface expression of the two proteins.",".",".",".",".","."]
["ENSRNOG00000021586",1,0.064330438,36,2.324226948,0.027678209,-5.175105621,{"v":5.19617e-10,"d":"5.20E-10"},{"v":5.42143e-10,"d":"5.42E-10"},"down","yes","Gpr39","protein_coding","chr13:37115102-37328267:+","gi|167555093|ref|NP_001107864.1|",2265,0,"G-protein coupled receptor 39 isoform 1 [Rattus norvegicus]","gi|55153908|gb|BC085285.1|",1995,0,"Mus musculus G protein-coupled receptor 39, mRNA (cDNA clone MGC:102647 IMAGE:30745457), complete cds","Q5U431",829,0,"G-protein coupled receptor 39",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0002024|diet induced thermogenesis;GO:0007186|G protein-coupled receptor signaling pathway;GO:0008343|adult feeding behavior;GO:0019216|regulation of lipid metabolic process;GO:0030641|regulation of cellular pH;GO:0032024|positive regulation of insulin secretion;GO:0035483|gastric emptying;GO:0035774|positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0042391|regulation of membrane potential;GO:0042593|glucose homeostasis;GO:0042632|cholesterol homeostasis;GO:0043406|positive regulation of MAP kinase activity;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;GO:0060455|negative regulation of gastric acid secretion;GO:0071294|cellular response to zinc ion;","GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;","K08412","GPR39; G protein-coupled receptor 39"]
["ENSRNOG00000069681",19,1.222278326,78,5.035825053,0.242716598,-2.042655325,{"v":5.23762e-10,"d":"5.24E-10"},{"v":5.46268E-10,"d":"5.46E-10"},"down","yes","ENSRNOG00000069681","pseudogene","chr4:31200445-31205142:-","gi|672018004|ref|XP_008773887.1|",7451,0,"PREDICTED: LOW QUALITY PROTEIN: sterile alpha motif domain-containing protein 9-like [Rattus norvegicus]","gi|672018003|ref|XM_008775665.1|",1495,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102553788 (LOC102553788), transcript variant X1, mRNA","Q69Z37",2424,0,"Sterile alpha motif domain-containing protein 9-like",".",".",".",".","pfam00536","SAM_1","SAM domain (Sterile alpha motif). It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.",".",".",".",".","."]
["ENSRNOG00000022426",10,0.643304382,59,3.80914972,0.168883984,-2.565895574,{"v":5.71252e-10,"d":"5.71E-10"},{"v":5.93956e-10,"d":"5.94E-10"},"down","yes","ENSRNOG00000022426","protein_coding","chr12:15229743-15242139:-","gi|564315040|ref|XP_006221342.1|",1571,0,"PREDICTED: uncharacterized protein LOC102546864 [Rattus norvegicus]","gi|672026549|ref|XM_008759032.1|",1675,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102546864 (LOC102546864), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam02628","COX15-CtaA","Cytochrome oxidase assembly protein. This is a family of integral membrane proteins. CtaA is required for cytochrome aa3 oxidase assembly in Bacillus subtilis. COX15 is required for cytochrome c oxidase assembly in yeast.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000025860",10,0.643304382,59,3.80914972,0.168883984,-2.565895574,{"v":5.71252e-10,"d":"5.71E-10"},{"v":5.93956e-10,"d":"5.94E-10"},"down","yes","Drc7","protein_coding","chr19:9943456-9961163:-","gi|157818245|ref|NP_001099639.1|",3861,0,"coiled-coil domain-containing protein lobo homolog [Rattus norvegicus]","gi|157818244|ref|NM_001106169.1|",2813,0,"Rattus norvegicus dynein regulatory complex subunit 7 (Drc7), mRNA","Q6V3W6",1413,0,"Dynein regulatory complex subunit 7",".",".",".",".","pfam01841","Transglut_core","Transglutaminase-like superfamily. This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterized transglutaminase, the human blood clotting factor XIIIa'. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase, it is proposed that many, if not all, microbial homologues of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease.","GO:0030317|flagellated sperm motility;GO:0048870|cell motility;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0031514|motile cilium;",".","K25451","DRC7; dynein regulatory complex subunit 7"]
["ENSRNOG00000023566",4,0.257321753,44,2.840721825,0.090583228,-3.464612238,{"v":6.20795e-10,"d":"6.21E-10"},{"v":6.4371e-10,"d":"6.44E-10"},"down","yes","Vwa3b","protein_coding","chr9:39250430-39419611:+","gi|672023915|ref|XP_008756232.1|",6407,0,"PREDICTED: von Willebrand factor A domain-containing protein 3B isoform X2 [Rattus norvegicus]","gi|672023914|ref|XM_008758010.1|",3937,0,"PREDICTED: Rattus norvegicus von Willebrand factor A domain containing 3B (Vwa3b), transcript variant X3, mRNA","Q502W6",1750,0,"von Willebrand factor A domain-containing protein 3B",".",".",".",".","pfam15057","DUF4537","Domain of unknown function (DUF4537). The function of this domain family is unknown. It is found in eukaryotes, and is typically between 119 and 141 amino acids in length. In humans, it is found in the chromosomal position C11orf16.",".","GO:0005654|nucleoplasm;GO:0005829|cytosol;",".","K24509","VWA3; von Willebrand factor A domain-containing protein 3"]
["ENSRNOG00000035633",4,0.257321753,44,2.840721825,0.090583228,-3.464612238,{"v":6.20795e-10,"d":"6.21E-10"},{"v":6.4371e-10,"d":"6.44E-10"},"down","yes","Mir142","miRNA","chr10:72557857-72557967:+",".",".",".",".","gi|982305356|ref|XM_015438367.1|",111,{"v":5e-50,"d":"5.00E-50"},"PREDICTED: Macaca fascicularis benzodiazepine receptor (peripheral) associated protein 1 (BZRAP1), transcript variant X21, mRNA",".",".",".",".",".",".",".",".","pfam02277","DBI_PRT","Phosphoribosyltransferase. This family of proteins represent the nicotinate-nucleotide- dimethylbenzimidazole phosphoribosyltransferase (NN:DBI PRT) enzymes involved in dimethylbenzimidazole synthesis. This function is essential to de novo cobalamin (vitamin B12) production in bacteria. Nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazole (DMB) phosphoribosyltransferase (CobT) from Salmonella enterica plays a central role in the synthesis of alpha-ribazole-5'-phosphate, an intermediate for the lower ligand of cobalamin.","GO:0036294|cellular response to decreased oxygen levels;GO:0071222|cellular response to lipopolysaccharide;GO:0071391|cellular response to estrogen stimulus;GO:1990830|cellular response to leukemia inhibitory factor;",".",".","K17022","MIR142; microRNA 142"]
["ENSRNOG00000036674",11,0.70763482,61,3.938273439,0.179681485,-2.476486338,{"v":6.50367e-10,"d":"6.50E-10"},{"v":6.73517e-10,"d":"6.74E-10"},"down","yes","Cd7","protein_coding","chr10:106304056-106306967:-","gi|157819011|ref|NP_001100544.1|",1010,{"v":6e-135,"d":"6.00E-135"},"T-cell antigen CD7 precursor [Rattus norvegicus]","gi|298887746|emb|FQ233656.1|",971,0,"Rattus norvegicus TL0AEA60YP20 mRNA sequence","P50283",320,{"v":1E-107,"d":"1.00E-107"},"T-cell antigen CD7",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0002250|adaptive immune response;GO:0048873|homeostasis of number of cells within a tissue;","GO:0016021|integral component of membrane;","GO:0038023|signaling receptor activity;","K06457","CD7; T-cell surface glycoprotein CD7"]
["ENSRNOG00000014156",3,0.192991315,41,2.647036246,0.072908452,-3.777770123,{"v":6.99182e-10,"d":"6.99E-10"},{"v":7.21975e-10,"d":"7.22E-10"},"down","yes","Fut7","protein_coding","chr3:8239384-8242260:+","gi|41054896|ref|NP_955785.1|",1882,0,"alpha-(1,3)-fucosyltransferase 7 [Rattus norvegicus]","gi|41054895|ref|NM_199491.1|",2005,0,"Rattus norvegicus fucosyltransferase 7 (alpha (1,3) fucosyltransferase) (Fut7), mRNA","Q11131",661,0,"Alpha-(1,3)-fucosyltransferase 7",".",".",".",".","pfam00852","Glyco_transf_10","Glycosyltransferase family 10 (fucosyltransferase). This family of Fucosyltransferases are the enzymes transferring fucose from GDP-Fucose to GlcNAc in an alpha1,3 linkage. This family is know as glycosyltransferase family 10.","GO:0001807|regulation of type IV hypersensitivity;GO:0002361|CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0002522|leukocyte migration involved in immune response;GO:0002523|leukocyte migration involved in inflammatory response;GO:0006486|protein glycosylation;GO:0006672|ceramide metabolic process;GO:0006954|inflammatory response;GO:0007566|embryo implantation;GO:0022407|regulation of cell-cell adhesion;GO:0022409|positive regulation of cell-cell adhesion;GO:0036065|fucosylation;GO:0045785|positive regulation of cell adhesion;GO:0046626|regulation of insulin receptor signaling pathway;GO:0060353|regulation of cell adhesion molecule production;GO:0097021|lymphocyte migration into lymphoid organs;GO:1903037|regulation of leukocyte cell-cell adhesion;GO:1903236|regulation of leukocyte tethering or rolling;GO:1903238|positive regulation of leukocyte tethering or rolling;GO:1904994|regulation of leukocyte adhesion to vascular endothelial cell;GO:1904996|positive regulation of leukocyte adhesion to vascular endothelial cell;GO:2000389|regulation of neutrophil extravasation;","GO:0005794|Golgi apparatus;GO:0005802|trans-Golgi network;GO:0016021|integral component of membrane;GO:0032580|Golgi cisterna membrane;","GO:0008417|fucosyltransferase activity;GO:0017083|4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity;GO:0046920|alpha-(1->3)-fucosyltransferase activity;","K07635","FUT7; galactoside alpha-1,3-fucosyltransferase 7 [EC:2.4.1.-]"]
["ENSRNOG00000047545",33,2.12290446,103,6.649871544,0.31923992,-1.647287027,{"v":7.05741e-10,"d":"7.06E-10"},{"v":7.28485e-10,"d":"7.28E-10"},"down","yes","Adra2a","protein_coding","chr1:253060218-253064365:+","gi|340805866|ref|NP_036871.3|",2136,0,"alpha-2A adrenergic receptor [Rattus norvegicus]","gi|340805865|ref|NM_012739.3|",2801,0,"Rattus norvegicus adrenoceptor alpha 2A (Adra2a), mRNA","P22909",796,0,"Alpha-2A adrenergic receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001819|positive regulation of cytokine production;GO:0002526|acute inflammatory response;GO:0006260|DNA replication;GO:0007165|signal transduction;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007193|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007565|female pregnancy;GO:0019229|regulation of vasoconstriction;GO:0030168|platelet activation;GO:0030335|positive regulation of cell migration;GO:0032147|activation of protein kinase activity;GO:0032148|activation of protein kinase B activity;GO:0032870|cellular response to hormone stimulus;GO:0035624|receptor transactivation;GO:0042311|vasodilation;GO:0042593|glucose homeostasis;GO:0042596|fear response;GO:0043268|positive regulation of potassium ion transport;GO:0043406|positive regulation of MAP kinase activity;GO:0043410|positive regulation of MAPK cascade;GO:0045741|positive regulation of epidermal growth factor-activated receptor activity;GO:0045955|negative regulation of calcium ion-dependent exocytosis;GO:0046676|negative regulation of insulin secretion;GO:0050955|thermoception;GO:0050995|negative regulation of lipid catabolic process;GO:0051044|positive regulation of membrane protein ectodomain proteolysis;GO:0051926|negative regulation of calcium ion transport;GO:0061179|negative regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0070473|negative regulation of uterine smooth muscle contraction;GO:0071875|adrenergic receptor signaling pathway;GO:0071880|adenylate cyclase-activating adrenergic receptor signaling pathway;GO:0071881|adenylate cyclase-inhibiting adrenergic receptor signaling pathway;GO:0071882|phospholipase C-activating adrenergic receptor signaling pathway;GO:0090303|positive regulation of wound healing;GO:1901020|negative regulation of calcium ion transmembrane transporter activity;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0043025|neuronal cell body;GO:0043235|receptor complex;GO:0043679|axon terminus;GO:0045202|synapse;GO:0098691|dopaminergic synapse;GO:0098978|glutamatergic synapse;GO:0098982|GABA-ergic synapse;GO:0099055|integral component of postsynaptic membrane;GO:0099059|integral component of presynaptic active zone membrane;GO:0099061|integral component of postsynaptic density membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004935|adrenergic receptor activity;GO:0004938|alpha2-adrenergic receptor activity;GO:0019901|protein kinase binding;GO:0031692|alpha-1B adrenergic receptor binding;GO:0031696|alpha-2C adrenergic receptor binding;GO:0031996|thioesterase binding;GO:0032795|heterotrimeric G-protein binding;GO:0042803|protein homodimerization activity;GO:0046982|protein heterodimerization activity;GO:0051379|epinephrine binding;GO:0051380|norepinephrine binding;","K04138","ADRA2A; adrenergic receptor alpha-2A"]
["ENSRNOG00000060325",2,0.128660876,38,2.453350667,0.052442921,-4.253108133,{"v":7.51265e-10,"d":"7.51E-10"},{"v":7.74217e-10,"d":"7.74E-10"},"down","yes","Lefty2","protein_coding","chr13:92615360-92619880:+","gi|56090596|ref|NP_001007557.1|",1795,0,"left-right determination factor 2 precursor [Rattus norvegicus]","gi|56090595|ref|NM_001007556.1|",1324,0,"Rattus norvegicus Left-right determination factor 2 (Lefty2), mRNA","P57785",637,0,"Left-right determination factor 2",".",".",".",".","pfam00688","TGFb_propeptide","TGF-beta propeptide. This propeptide is known as latency associated peptide (LAP) in TGF-beta. LAP is a homodimer which is disulfide linked to TGF-beta binding protein.","GO:0008150|biological_process;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0030509|BMP signaling pathway;GO:0060395|SMAD protein signal transduction;","GO:0005575|cellular_component;GO:0005615|extracellular space;","GO:0003674|molecular_function;GO:0005125|cytokine activity;GO:0005160|transforming growth factor beta receptor binding;GO:0008083|growth factor activity;","K04668","LEFTY; left-right determination factor"]
["ENSRNOG00000021207",0,0.032165219,35,2.259665088,0.014234507,-6.134463636,{"v":7.76778e-10,"d":"7.77E-10"},{"v":7.98923e-10,"d":"7.99E-10"},"down","yes","Lgals12","protein_coding","chr1:204832065-204842759:-","gi|157821763|ref|NP_001099803.1|",1654,0,"galectin-12 [Rattus norvegicus]","gi|157821762|ref|NM_001106333.1|",2793,0,"Rattus norvegicus lectin, galactoside-binding, soluble, 12 (Lgals12), mRNA","Q91VD1",607,0,"Galectin-12",".",".",".",".","pfam00337","Gal-bind_lectin","Galactoside-binding lectin. This family contains galactoside binding lectins.   The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).","GO:0045598|regulation of fat cell differentiation;GO:0050994|regulation of lipid catabolic process;GO:0097193|intrinsic apoptotic signaling pathway;GO:1904977|lymphatic endothelial cell migration;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0016021|integral component of membrane;","GO:0005178|integrin binding;GO:0030246|carbohydrate binding;GO:0030395|lactose binding;","K10095","LGALS12; galectin-12"]
["ENSRNOG00000021771",0,0.032165219,35,2.259665088,0.014234507,-6.134463636,{"v":7.76778e-10,"d":"7.77E-10"},{"v":7.98923e-10,"d":"7.99E-10"},"down","yes","Trim29","protein_coding","chr8:43682221-43706992:+","gi|149041424|gb|EDL95265.1|",3099,0,"tripartite motif protein 29 (predicted), isoform CRA_a [Rattus norvegicus]","gi|755529174|ref|XM_006510616.2|",2140,0,"PREDICTED: Mus musculus tripartite motif-containing 29 (Trim29), transcript variant X1, mRNA","Q8R2Q0",1078,0,"Tripartite motif-containing protein 29",".",".",".",".","pfam00643","zf-B_box","B-box zinc finger.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:1900181|negative regulation of protein localization to nucleus;","GO:0005737|cytoplasm;","GO:0002039|p53 binding;GO:0008270|zinc ion binding;GO:0042802|identical protein binding;","K12010","TRIM29, ATDC; tripartite motif-containing protein 29"]
["ENSRNOG00000070677",0,0.032165219,35,2.259665088,0.014234507,-6.134463636,{"v":7.76778e-10,"d":"7.77E-10"},{"v":7.98923e-10,"d":"7.99E-10"},"down","yes","ENSRNOG00000070677","protein_coding","chr12:18516156-18525346:+","gi|564378700|ref|XP_006249121.1|",1086,{"v":2E-140,"d":"2.00E-140"},"PREDICTED: paired immunoglobulin-like type 2 receptor beta isoform X1 [Rattus norvegicus]","gi|672072515|ref|XR_595294.1|",1193,0,"PREDICTED: Rattus norvegicus similar to paired immunoglobin-like type 2 receptor beta (LOC681341), transcript variant X7, misc_RNA","Q2YFS2",308,{"v":9e-98,"d":"9.00E-98"},"Paired immunoglobulin-like type 2 receptor beta",".",".",".",".","pfam14329","DUF4386","Domain of unknown function (DUF4386). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 214 and 245 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000026989",1,0.064330438,35,2.259665088,0.028469015,-5.134463636,{"v":9.29849e-10,"d":"9.30E-10"},{"v":9.52755e-10,"d":"9.53E-10"},"down","yes","Gapt","protein_coding","chr2:41927532-41932093:-","gi|157823571|ref|NP_001102961.1|",712,{"v":9e-87,"d":"9.00E-87"},"protein GAPT [Rattus norvegicus]","gi|672041425|ref|XM_006231916.2|",1953,0,"PREDICTED: Rattus norvegicus Grb2-binding adaptor protein, transmembrane (Gapt), transcript variant X1, mRNA","Q8CB93",208,{"v":1E-61,"d":"1.00E-61"},"Protein GAPT",".",".",".",".","pfam11770","GAPT","GRB2-binding adapter (GAPT). This is a family of transmembrane proteins which bind the growth factor receptor-bound protein 2 (GRB2) in B cells. In contrast to other transmembrane adaptor proteins, GAPT is not phosphorylated upon BCR ligation. It associates with GRB2 constitutively through its proline-rich region.","GO:0001782|B cell homeostasis;GO:0002322|B cell proliferation involved in immune response;GO:0002381|immunoglobulin production involved in immunoglobulin mediated immune response;","GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;",".",".","."]
["ENSRNOG00000011033",7,0.450313067,51,3.292654842,0.136762913,-2.870251039,{"v":9.65437E-10,"d":"9.65E-10"},{"v":9.88688e-10,"d":"9.89E-10"},"down","yes","Tekt2","protein_coding","chr5:138619667-138623204:-","gi|58865522|ref|NP_001011977.1|",2169,0,"tektin-2 [Rattus norvegicus]","gi|58865521|ref|NM_001011977.1|",1530,0,"Rattus norvegicus tektin 2 (Tekt2), mRNA","Q6AYM2",840,0,"Tektin-2",".",".",".",".","pfam03148","Tektin","Tektin family. Tektins are cytoskeletal proteins. They have been demonstrated in such cellular sites as centrioles, basal bodies, and along ciliary and flagellar doublet microtubules. Tektins form unique protofilaments, organized as longitudinal polymers of tektin heterodimers with axial periodicity matching tubulin. Tektin polypeptides consist of several alpha-helical regions that are predicted to form coiled coils. Indeed, tektins share considerable structural similarities with intermediate filament proteins. Possible functional roles for tektins are: stabilisation of tubulin protofilaments; attachment of A and B-tubules in ciliary/flagellar microtubule doublets and C-tubules in centrioles; binding of axonemal components.","GO:0030317|flagellated sperm motility;GO:0036159|inner dynein arm assembly;GO:0060271|cilium assembly;GO:0060294|cilium movement involved in cell motility;","GO:0005737|cytoplasm;GO:0005815|microtubule organizing center;GO:0005874|microtubule;GO:0015630|microtubule cytoskeleton;GO:0031514|motile cilium;",".","K18629","TEKT2; tektin-2"]
["ENSRNOG00000008915",10,0.643304382,58,3.74458786,0.171795777,-2.54123352,{"v":9.81355e-10,"d":"9.81E-10"},{"v":1.00409E-9,"d":"1.00E-09"},"down","yes","Prima1","protein_coding","chr6:122338370-122389921:-","gi|672056787|ref|XP_008763071.1|",877,{"v":3e-106,"d":"3.00E-106"},"PREDICTED: proline-rich membrane anchor 1 isoform X2 [Rattus norvegicus]","gi|672056786|ref|XM_008764849.1|",3518,0,"PREDICTED: Rattus norvegicus proline rich membrane anchor 1 (Prima1), transcript variant X1, mRNA","D3ZZP4",251,{"v":2e-75,"d":"2.00E-75"},"Proline-rich membrane anchor 1",".",".",".",".","pfam02500","DNA_pack_N","Probable DNA packing protein, N-terminus. This family includes proteins that are probably involved in DNA packing in herpesvirus. This domain is normally found at the N-terminus of the protein.","GO:0042135|neurotransmitter catabolic process;GO:0051649|establishment of localization in cell;","GO:0016021|integral component of membrane;GO:0031226|intrinsic component of plasma membrane;GO:0045202|synapse;","GO:0019899|enzyme binding;GO:0043495|protein membrane anchor;",".","."]
["ENSRNOG00000055371",43,2.766208842,119,7.682861299,0.360049301,-1.473733628,{"v":1.00129E-9,"d":"1.00E-09"},{"v":1.02357E-9,"d":"1.02E-09"},"down","yes","Sptbn4","protein_coding","chr1:82650751-82737228:-","gi|672035701|ref|XP_008757362.1|",10998,0,"PREDICTED: spectrin beta chain, non-erythrocytic 4 isoform X1 [Rattus norvegicus]","gi|683523969|ref|NM_001100845.2|",8736,0,"Rattus norvegicus spectrin, beta, non-erythrocytic 4 (Sptbn4), mRNA","Q9H254",4020,0,"Spectrin beta chain, non-erythrocytic 4","SPAC15A10.08",252,{"v":2e-69,"d":"2.00E-69"},"COG5069","pfam00307","CH","Calponin homology (CH) domain. The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.","GO:0002028|regulation of sodium ion transport;GO:0007010|cytoskeleton organization;GO:0007409|axonogenesis;GO:0007605|sensory perception of sound;GO:0007628|adult walking behavior;GO:0008150|biological_process;GO:0009566|fertilization;GO:0010459|negative regulation of heart rate;GO:0019226|transmission of nerve impulse;GO:0021952|central nervous system projection neuron axonogenesis;GO:0022414|reproductive process;GO:0030534|adult behavior;GO:0033135|regulation of peptidyl-serine phosphorylation;GO:0034613|cellular protein localization;GO:0040018|positive regulation of multicellular organism growth;GO:0045162|clustering of voltage-gated sodium channels;GO:0051693|actin filament capping;GO:0061337|cardiac conduction;GO:0072659|protein localization to plasma membrane;","GO:0005737|cytoplasm;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0005912|adherens junction;GO:0008091|spectrin;GO:0014704|intercalated disc;GO:0016020|membrane;GO:0016363|nuclear matrix;GO:0016605|PML body;GO:0030424|axon;GO:0033268|node of Ranvier;GO:0033270|paranode region of axon;GO:0043025|neuronal cell body;GO:0043194|axon initial segment;GO:0043203|axon hillock;GO:0070852|cell body fiber;","GO:0003674|molecular_function;GO:0003779|actin binding;GO:0005200|structural constituent of cytoskeleton;GO:0005543|phospholipid binding;GO:0019902|phosphatase binding;GO:0030506|ankyrin binding;GO:0030507|spectrin binding;","K06115","SPTB; spectrin beta"]
["ENSRNOG00000019418",37,2.380226213,109,7.037242702,0.338232787,-1.563911579,{"v":1.00604E-9,"d":"1.01E-09"},{"v":1.02824E-9,"d":"1.03E-09"},"down","yes","Lrrc4b","protein_coding","chr1:94935603-94956263:+","gi|402692348|ref|NP_001258010.1|",2797,0,"leucine-rich repeat-containing protein 4B precursor [Rattus norvegicus]","gi|402692347|ref|NM_001271081.1|",2698,0,"Rattus norvegicus leucine rich repeat containing 4B (Lrrc4b), mRNA","P0CC10",1082,0,"Leucine-rich repeat-containing protein 4B","SPy1798",65.9,{"v":5e-10,"d":"5.00E-10"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0051965|positive regulation of synapse assembly;GO:0099151|regulation of postsynaptic density assembly;GO:0099560|synaptic membrane adhesion;GO:1905606|regulation of presynapse assembly;","GO:0005886|plasma membrane;GO:0042734|presynaptic membrane;GO:0044300|cerebellar mossy fiber;GO:0098978|glutamatergic synapse;GO:0099061|integral component of postsynaptic density membrane;","GO:0005102|signaling receptor binding;","K16360","LRRC4B, NGL3; netrin-G3 ligand"]
["ENSRNOG00000033906",48,3.087861033,127,8.199356176,0.376597987,-1.408902805,{"v":1.04916e-09,"d":"1.05E-09"},{"v":1.07135E-9,"d":"1.07E-09"},"down","yes","Zfp667","protein_coding","chr1:67601807-67622041:-","gi|56676352|ref|NP_001008557.1|",3112,0,"zinc finger protein 667 [Rattus norvegicus]","gi|56676351|ref|NM_001008557.1|",3380,0,"Rattus norvegicus zinc finger protein 667 (Zfp667), mRNA","Q5MYW4",1201,0,"Zinc finger protein 667",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006357|regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0046872|metal ion binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSRNOG00000034177",28,1.801252269,93,6.004252948,0.299996067,-1.736984508,{"v":1.18991e-09,"d":"1.19E-09"},{"v":1.21247e-09,"d":"1.21E-09"},"down","yes","Efna5","protein_coding","chr9:102320295-102597413:-","gi|6753724|ref|NP_034239.1|",1011,{"v":1e-124,"d":"1.00E-124"},"ephrin-A5 isoform 2 precursor [Mus musculus]","gi|77020717|gb|AC154385.2|",1894,0,"Mus musculus BAC clone RP23-23O22 from chromosome 17, complete sequence","P97605",378,{"v":6e-120,"d":"6.00E-120"},"Ephrin-A5",".",".",".",".","pfam00812","Ephrin","Ephrin.","GO:0007411|axon guidance;GO:0007413|axonal fasciculation;GO:0007417|central nervous system development;GO:0007420|brain development;GO:0022407|regulation of cell-cell adhesion;GO:0022604|regulation of cell morphogenesis;GO:0031290|retinal ganglion cell axon guidance;GO:0032956|regulation of actin cytoskeleton organization;GO:0043087|regulation of GTPase activity;GO:0048013|ephrin receptor signaling pathway;GO:0048668|collateral sprouting;GO:0048672|positive regulation of collateral sprouting;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050919|negative chemotaxis;GO:0051893|regulation of focal adhesion assembly;GO:0051965|positive regulation of synapse assembly;GO:0061178|regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0070507|regulation of microtubule cytoskeleton organization;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0099560|synaptic membrane adhesion;GO:1900025|negative regulation of substrate adhesion-dependent cell spreading;GO:1904322|cellular response to forskolin;","GO:0005604|basement membrane;GO:0005886|plasma membrane;GO:0005901|caveola;GO:0005912|adherens junction;GO:0031362|anchored component of external side of plasma membrane;GO:0071944|cell periphery;GO:0098982|GABA-ergic synapse;","GO:0005169|neurotrophin TRKB receptor binding;GO:0045499|chemorepellent activity;GO:0046875|ephrin receptor binding;","K05462","EFNA; ephrin-A"]
["ENSRNOG00000063314",97,6.240052504,200,12.91237193,0.483261521,-1.049123967,{"v":1.29013E-9,"d":"1.29E-09"},{"v":1.31203e-09,"d":"1.31E-09"},"down","yes","Utp23","protein_coding","chr7:83189656-83196655:+","gi|187282097|ref|NP_001119738.1|",1163,{"v":1e-149,"d":"1.00E-149"},"rRNA-processing protein UTP23 homolog [Rattus norvegicus]","gi|187282096|ref|NM_001126266.1|",985,0,"Rattus norvegicus UTP23, small subunit processome component (Utp23), mRNA","Q9CX11",424,{"v":4e-140,"d":"4.00E-140"},"rRNA-processing protein UTP23 homolog","SPCC18.12c",101,{"v":2e-22,"d":"2.00E-22"},"COG1412","pfam04900","Fcf1","Fcf1. Fcf1 is a nucleolar protein involved in pre-rRNA processing. Depletion of yeast Fcf1 and Fcf2 leads to a decrease in synthesis of the 18S rRNA and results in a deficit in 40S ribosomal subunits.",".",".",".",".","."]
["ENSRNOG00000021966",6,0.385982629,48,3.098969263,0.124551938,-3.005180619,{"v":1.29691E-9,"d":"1.30E-09"},{"v":1.31845e-09,"d":"1.32E-09"},"down","yes","Il17rd","protein_coding","chr16:2228287-2292556:+","gi|300794298|ref|NP_001178866.1|",3570,0,"interleukin-17 receptor D precursor [Rattus norvegicus]","gi|672079319|ref|XM_006252636.2|",5395,0,"PREDICTED: Rattus norvegicus interleukin 17 receptor D (Il17rd), transcript variant X1, mRNA","Q8JZL1",1288,0,"Interleukin-17 receptor D",".",".",".",".","pfam08357","SEFIR","SEFIR domain. This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain (pfam01582), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways.","GO:0010719|negative regulation of epithelial to mesenchymal transition;GO:0019221|cytokine-mediated signaling pathway;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;","GO:0005654|nucleoplasm;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;","GO:0030368|interleukin-17 receptor activity;","K05167","IL17RD, SEF; interleukin 17 receptor D"]
["ENSRNOG00000048209",0,0.032165219,34,2.195103228,0.014653169,-6.092643461,{"v":1.33127e-09,"d":"1.33E-09"},{"v":1.35122E-9,"d":"1.35E-09"},"down","yes","Eps8l3","protein_coding","chr2:195514692-195528085:+","gi|157823675|ref|NP_001099933.1|",2738,0,"epidermal growth factor receptor kinase substrate 8-like protein 3 [Rattus norvegicus]","gi|157823674|ref|NM_001106463.1|",2687,0,"Rattus norvegicus EPS8-like 3 (Eps8l3), mRNA","Q91WL0",976,0,"Epidermal growth factor receptor kinase substrate 8-like protein 3",".",".",".",".","pfam08416","PTB","Phosphotyrosine-binding domain. The phosphotyrosine-binding domain (PTB, also phosphotyrosine-interaction or PI domain) in the protein tensin tends to be found at the C-terminus. Tensin is a multi-domain protein that binds to actin filaments and functions as a focal-adhesion molecule (focal adhesions are regions of plasma membrane through which cells attach to the extracellular matrix). Human tensin has actin-binding sites, an SH2 (pfam00017) domain and a region similar to the tumor suppressor PTEN. The PTB domain interacts with the cytoplasmic tails of beta integrin by binding to an NPXY motif.",".",".",".","K17277","EPS8; epidermal growth factor receptor kinase substrate 8"]
["ENSRNOG00000048881",0,0.032165219,34,2.195103228,0.014653169,-6.092643461,{"v":1.33127e-09,"d":"1.33E-09"},{"v":1.35122E-9,"d":"1.35E-09"},"down","yes","RGD1561730","protein_coding","chr12:18210535-18216443:-","gi|672026617|ref|XP_008757594.1|",1110,{"v":3E-148,"d":"3.00E-148"},"PREDICTED: paired immunoglobulin-like type 2 receptor beta isoform X2 [Rattus norvegicus]","gi|672072497|ref|XM_008769088.1|",1240,0,"PREDICTED: Rattus norvegicus similar to cell surface receptor FDFACT (RGD1561730), transcript variant X2, mRNA","Q2YFS2",261,{"v":2e-83,"d":"2.00E-83"},"Paired immunoglobulin-like type 2 receptor beta",".",".",".",".","pfam03228","Adeno_VII","Adenoviral core protein VII. The function of this protein is unknown. It has a conserved amino terminus of 50 residues followed by a positively charged tail, suggesting it may interact with nucleic acid. The major core protein of the adenovirus, protein VII, was found to be associated with viral DNA throughout infection. The precursor to protein VII were shown to be in vivo and in vitro acceptors of ADP-ribose. The ADP-ribosylated core proteins were assembled into mature virus particles. ADP-ribosylation of adenovirus core proteins may have a role in virus decapsidation.",".","GO:0016021|integral component of membrane;",".","K15411","PILR; paired immunoglobulin-like type 2 receptor"]
["ENSRNOG00000056174",26,1.672591393,89,5.746005509,0.291087676,-1.780474332,{"v":1.42575E-9,"d":"1.43E-09"},{"v":1.4448E-9,"d":"1.44E-09"},"down","yes","ENSRNOG00000056174","protein_coding","chrX:151530390-151560826:-","gi|564329380|ref|XP_006229625.1|",3575,0,"PREDICTED: PDZ domain-containing protein 4 isoform X2 [Rattus norvegicus]","gi|672088929|ref|XM_006229563.2|",3486,0,"PREDICTED: Rattus norvegicus PDZ domain containing 4 (Pdzd4), transcript variant X2, mRNA","Q9QY39",1349,0,"PDZ domain-containing protein 4",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.",".",".",".","K24056","PDZD4; PDZ domain-containing protein 4"]
["ENSRNOG00000067856",48,3.087861033,126,8.134794317,0.37958686,-1.397498042,{"v":1.53728e-09,"d":"1.54E-09"},{"v":1.55341e-09,"d":"1.55E-09"},"down","yes","ENSRNOG00000067856","lncRNA","chr16:66928433-66931855:-",".",".",".",".","gi|84875651|gb|AC156553.17|",259,{"v":7e-131,"d":"7.00E-131"},"Mus musculus chromosome 8, clone RP23-106I21, complete sequence",".",".",".",".",".",".",".",".","pfam15351","JCAD","Junctional protein associated with coronary artery disease. JCAD is a component of VE-cadherin-based cell-cell junctions in endothelial cells. The cell-cell or adherens junction is an adhesion complex that plays a crucial role in the organisation and function of epithelial and endothelial cellular sheets. These junctions join the actin cytoskeleton to the plasma membrane to form adhesive contacts between cells or between cells and extracellular matrix. The junctions also mediate both cell adhesion and cell-signalling. JCAD localizes close to the apical membrane in epithelial cells. This family is found in eukaryotes.",".",".",".",".","."]
["ENSRNOG00000024390",29,1.865582707,94,6.068814808,0.307404784,-1.701788476,{"v":1.67068e-09,"d":"1.67E-09"},{"v":1.68286e-09,"d":"1.68E-09"},"down","yes","Osm","protein_coding","chr14:79104344-79108313:+","gi|55741439|ref|NP_001006962.1|",1118,{"v":9e-147,"d":"9.00E-147"},"oncostatin-M precursor [Rattus norvegicus]","gi|672076593|ref|XM_006251200.2|",1490,0,"PREDICTED: Rattus norvegicus oncostatin M (Osm), transcript variant X2, mRNA","Q65Z15",435,{"v":3E-148,"d":"3.00E-148"},"Oncostatin-M",".",".",".",".","pfam01291","LIF_OSM","LIF / OSM family.","GO:0006955|immune response;GO:0007260|tyrosine phosphorylation of STAT protein;GO:0007422|peripheral nervous system development;GO:0008284|positive regulation of cell proliferation;GO:0009408|response to heat;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0032740|positive regulation of interleukin-17 production;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0038165|oncostatin-M-mediated signaling pathway;GO:0040008|regulation of growth;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0043410|positive regulation of MAPK cascade;GO:0045835|negative regulation of meiotic nuclear division;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046888|negative regulation of hormone secretion;GO:0048266|behavioral response to pain;GO:0050729|positive regulation of inflammatory response;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0051897|positive regulation of protein kinase B signaling;GO:2001235|positive regulation of apoptotic signaling pathway;","GO:0005615|extracellular space;","GO:0005125|cytokine activity;GO:0005147|oncostatin-M receptor binding;GO:0008083|growth factor activity;","K05418","OSM; oncostatin M"]
["ENSRNOG00000037190",10,0.643304382,57,3.680026,0.174809738,-2.516142539,{"v":1.6827E-9,"d":"1.68E-09"},{"v":1.69466E-9,"d":"1.69E-09"},"down","yes","Cd101","protein_coding","chr2:188422351-188459502:-","gi|403420584|ref|NP_001258146.1|",5177,0,"immunoglobulin superfamily member 2 precursor [Rattus norvegicus]","gi|672043656|ref|XM_006233049.2|",3211,0,"PREDICTED: Rattus norvegicus CD101 molecule (Cd101), transcript variant X2, mRNA","A8E0Y8",1749,0,"Immunoglobulin superfamily member 2",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0002763|positive regulation of myeloid leukocyte differentiation;","GO:0016021|integral component of membrane;",".","K06522","IGSF2_3, CD101; immunoglobulin superfamily, member 2/3"]
["ENSRNOG00000021056",66,4.24580892,153,9.877964527,0.429826298,-1.218174343,{"v":2.1609e-09,"d":"2.16E-09"},{"v":2.16519E-9,"d":"2.17E-09"},"down","yes","Kcnj14","protein_coding","chr1:96293435-96495459:-","gi|24962814|ref|NP_733836.1|",2050,0,"ATP-sensitive inward rectifier potassium channel 14 [Rattus norvegicus]","gi|24962813|ref|NM_170718.1|",2736,0,"Rattus norvegicus potassium voltage-gated channel subfamily J member 14 (Kcnj14), mRNA","O70596",775,0,"ATP-sensitive inward rectifier potassium channel 14",".",".",".",".","pfam01007","IRK","Inward rectifier potassium channel.","GO:0034765|regulation of ion transmembrane transport;GO:1990573|potassium ion import across plasma membrane;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0043025|neuronal cell body;","GO:0005242|inward rectifier potassium channel activity;","K05007","KCNJ14, KIR2.4; potassium inwardly-rectifying channel subfamily J member 14"]
["ENSRNOG00000000055",0,0.032165219,33,2.130541369,0.015097205,-6.049574739,{"v":2.28758e-09,"d":"2.29E-09"},{"v":2.2869E-9,"d":"2.29E-09"},"down","yes","Fcrl6","protein_coding","chr13:85066694-85072600:-","gi|257900499|ref|NP_001158198.1|",1151,{"v":4e-155,"d":"4.00E-155"},"cell surface glycoprotein gp42 precursor [Rattus norvegicus]","gi|298908446|emb|FQ228799.1|",1068,0,"Rattus norvegicus TL0ADA51YK23 mRNA sequence","P23505",446,{"v":7e-156,"d":"7.00E-156"},"Cell surface glycoprotein gp42",".",".",".",".","pfam13927","Ig_3","Immunoglobulin domain. This family contains immunoglobulin-like domains.","GO:0007166|cell surface receptor signaling pathway;GO:0050776|regulation of immune response;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0031225|anchored component of membrane;","GO:0004888|transmembrane signaling receptor activity;GO:0019902|phosphatase binding;GO:0019903|protein phosphatase binding;GO:0042289|MHC class II protein binding;","K17273","FCRL6; Fc receptor-like protein 6"]
["ENSRNOG00000013133",0,0.032165219,33,2.130541369,0.015097205,-6.049574739,{"v":2.28758e-09,"d":"2.29E-09"},{"v":2.2869E-9,"d":"2.29E-09"},"down","yes","Foxa2","protein_coding","chr3:135470131-135474326:-","gi|913041|gb|AAB33815.1|",1500,0,"hepatocyte nuclear factor 3 beta, HNF3 beta [rats, AR42J exocrine pancreatic cells, Peptide, 459 aa]","gi|6981035|ref|NM_012743.1|",2166,0,"Rattus norvegicus forkhead box A2 (Foxa2), mRNA","P35583",576,0,"Hepatocyte nuclear factor 3-beta","ECU11g1330",99,{"v":8e-22,"d":"8.00E-22"},"COG5025","pfam00250","Fork_head","Fork head domain.","GO:0000432|positive regulation of transcription from RNA polymerase II promoter by glucose;GO:0001701|in utero embryonic development;GO:0001705|ectoderm formation;GO:0001708|cell fate specification;GO:0006325|chromatin organization;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007219|Notch signaling pathway;GO:0007389|pattern specification process;GO:0008344|adult locomotory behavior;GO:0009653|anatomical structure morphogenesis;GO:0009952|anterior/posterior pattern specification;GO:0009953|dorsal/ventral pattern formation;GO:0010468|regulation of gene expression;GO:0010719|negative regulation of epithelial to mesenchymal transition;GO:0019216|regulation of lipid metabolic process;GO:0019218|regulation of steroid metabolic process;GO:0021533|cell differentiation in hindbrain;GO:0021904|dorsal/ventral neural tube patterning;GO:0023019|signal transduction involved in regulation of gene expression;GO:0030154|cell differentiation;GO:0030193|regulation of blood coagulation;GO:0030324|lung development;GO:0031018|endocrine pancreas development;GO:0032525|somite rostral/caudal axis specification;GO:0032868|response to insulin;GO:0033132|negative regulation of glucokinase activity;GO:0040019|positive regulation of embryonic development;GO:0043433|negative regulation of DNA-binding transcription factor activity;GO:0045665|negative regulation of neuron differentiation;GO:0045666|positive regulation of neuron differentiation;GO:0045880|positive regulation of smoothened signaling pathway;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0045945|positive regulation of transcription by RNA polymerase III;GO:0048382|mesendoderm development;GO:0048468|cell development;GO:0048646|anatomical structure formation involved in morphogenesis;GO:0048665|neuron fate specification;GO:0060441|epithelial tube branching involved in lung morphogenesis;GO:0060487|lung epithelial cell differentiation;GO:0061178|regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0061448|connective tissue development;GO:0061987|negative regulation of transcription from RNA polymerase II promoter by glucose;GO:0071276|cellular response to cadmium ion;GO:0071542|dopaminergic neuron differentiation;GO:0090009|primitive streak formation;GO:2000543|positive regulation of gastrulation;GO:2000971|negative regulation of detection of glucose;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005737|cytoplasm;GO:0030054|cell junction;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003690|double-stranded DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0005515|protein binding;GO:0019900|kinase binding;GO:0019904|protein domain specific binding;GO:0043565|sequence-specific DNA binding;GO:0046332|SMAD binding;GO:1990837|sequence-specific double-stranded DNA binding;","K08035","FOXA2, HNF3B; forkhead box protein A2, hepatocyte nuclear factor 3-beta"]
["ENSRNOG00000063128",52,3.345182786,131,8.457603615,0.395523713,-1.338163903,{"v":2.545e-09,"d":"2.55E-09"},{"v":2.53935e-09,"d":"2.54E-09"},"down","yes","ENSRNOG00000063128","lncRNA","chr13:103495432-103497413:-",".",".",".",".","gi|74203083|dbj|AK145100.1|",1049,0,"Mus musculus mammary gland RCB-0526 Jyg-MC(A) cDNA, RIKEN full-length enriched library, clone:G830042M08 product:solute carrier family 30 (zinc transporter), member 1, full insert sequence",".",".",".",".",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.",".",".",".",".","."]
["ENSRNOG00000037757",7,0.450313067,49,3.163531123,0.142345073,-2.812535541,{"v":2.98484e-09,"d":"2.98E-09"},{"v":2.96837e-09,"d":"2.97E-09"},"down","yes","Calhm6","protein_coding","chr20:26095592-26097278:-","gi|68163374|ref|NP_001020147.1|",1387,0,"protein FAM26F [Rattus norvegicus]","gi|298890069|emb|FQ230614.1|",1079,0,"Rattus norvegicus TL0AEA8YL17 mRNA sequence","Q561R8",538,0,"Calcium homeostasis modulator protein 6",".",".",".",".","pfam14798","Ca_hom_mod","Calcium homeostasis modulator. This family of proteins control cytosolic calcium concentration. They are transmembrane proteins which may be pore-forming ion channels.","GO:0098655|cation transmembrane transport;","GO:0005887|integral component of plasma membrane;","GO:0005261|cation channel activity;",".","."]
["ENSRNOG00000019022",1,0.064330438,33,2.130541369,0.030194409,-5.049574739,{"v":2.9944e-09,"d":"2.99E-09"},{"v":2.97684e-09,"d":"2.98E-09"},"down","yes","Fam89a","protein_coding","chr19:52710019-52722631:-","gi|58743349|ref|NP_001011711.1|",569,{"v":2e-67,"d":"2.00E-67"},"protein FAM89A [Rattus norvegicus]","gi|79152851|gb|BC107921.1|",1370,0,"Rattus norvegicus family with sequence similarity 89, member A, mRNA (cDNA clone MGC:124908 IMAGE:7445343), complete cds",".",".",".",".",".",".",".",".","pfam07816","DUF1645","Protein of unknown function (DUF1645). These sequences are derived from a number of hypothetical plant proteins. The region in question is approximately 270 amino acids long. Some members of this family are annotated as yeast pheromone receptor proteins AR781 but no literature was found to support this.",".",".",".",".","."]
["ENSRNOG00000011420",55,3.5381741,135,8.715851053,0.405947059,-1.300636503,{"v":3.26769e-09,"d":"3.27E-09"},{"v":3.24007E-9,"d":"3.24E-09"},"down","yes","Mtmr7","protein_coding","chr16:51641190-51732182:+","gi|149021359|gb|EDL78822.1|",2460,0,"myotubularin related protein 7 (predicted), isoform CRA_b [Rattus norvegicus]","gi|157819058|ref|NM_001107312.1|",2669,0,"Rattus norvegicus myotubularin related protein 7 (Mtmr7), mRNA","Q9Z2C9",918,0,"Myotubularin-related protein 7",".",".",".",".","pfam06602","Myotub-related","Myotubularin-like phosphatase domain. This family represents the phosphatase domain within eukaryotic myotubularin-related proteins. Myotubularin is a dual-specific lipid phosphatase that dephosphorylates phosphatidylinositol 3-phosphate and phosphatidylinositol (3,5)-bi-phosphate. Mutations in gene encoding myotubularin-related proteins have been associated with disease.","GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0046855|inositol phosphate dephosphorylation;GO:0046856|phosphatidylinositol dephosphorylation;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016020|membrane;","GO:0004438|phosphatidylinositol-3-phosphatase activity;GO:0004725|protein tyrosine phosphatase activity;GO:0016312|inositol bisphosphate phosphatase activity;","K18083","MTMR6_7_8; myotubularin-related protein 6/7/8 [EC:3.1.3.64 3.1.3.95]"]
["ENSRNOG00000012531",48,3.087861033,124,8.005670597,0.385709229,-1.374414429,{"v":3.28036E-9,"d":"3.28E-09"},{"v":3.25207e-09,"d":"3.25E-09"},"down","yes","Ephb2","protein_coding","chr5:148897246-149077059:-","gi|38614379|gb|AAH62924.1|",5186,0,"Ephb2 protein, partial [Mus musculus]","gi|187960052|ref|NM_001127319.1|",2953,0,"Rattus norvegicus Eph receptor B2 (Ephb2), mRNA","P54763",1977,0,"Ephrin type-B receptor 2",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0000902|cell morphogenesis;GO:0001525|angiogenesis;GO:0001655|urogenital system development;GO:0001933|negative regulation of protein phosphorylation;GO:0002639|positive regulation of immunoglobulin production;GO:0006468|protein phosphorylation;GO:0006469|negative regulation of protein kinase activity;GO:0007162|negative regulation of cell adhesion;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007275|multicellular organism development;GO:0007411|axon guidance;GO:0007413|axonal fasciculation;GO:0007611|learning or memory;GO:0007612|learning;GO:0009887|animal organ morphogenesis;GO:0010628|positive regulation of gene expression;GO:0016310|phosphorylation;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0021631|optic nerve morphogenesis;GO:0021934|hindbrain tangential cell migration;GO:0021952|central nervous system projection neuron axonogenesis;GO:0022038|corpus callosum development;GO:0030193|regulation of blood coagulation;GO:0030335|positive regulation of cell migration;GO:0030890|positive regulation of B cell proliferation;GO:0031290|retinal ganglion cell axon guidance;GO:0031915|positive regulation of synaptic plasticity;GO:0032760|positive regulation of tumor necrosis factor production;GO:0033674|positive regulation of kinase activity;GO:0042113|B cell activation;GO:0042472|inner ear morphogenesis;GO:0046425|regulation of JAK-STAT cascade;GO:0046580|negative regulation of Ras protein signal transduction;GO:0048013|ephrin receptor signaling pathway;GO:0048168|regulation of neuronal synaptic plasticity;GO:0048170|positive regulation of long-term neuronal synaptic plasticity;GO:0048593|camera-type eye morphogenesis;GO:0050770|regulation of axonogenesis;GO:0050771|negative regulation of axonogenesis;GO:0050878|regulation of body fluid levels;GO:0051489|regulation of filopodium assembly;GO:0051963|regulation of synapse assembly;GO:0051965|positive regulation of synapse assembly;GO:0060021|roof of mouth development;GO:0060996|dendritic spine development;GO:0060997|dendritic spine morphogenesis;GO:0061003|positive regulation of dendritic spine morphogenesis;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0071222|cellular response to lipopolysaccharide;GO:0071679|commissural neuron axon guidance;GO:0097104|postsynaptic membrane assembly;GO:0099557|trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission;GO:0106028|neuron projection retraction;GO:0110077|vesicle-mediated intercellular transport;GO:0120192|tight junction assembly;GO:1900016|negative regulation of cytokine production involved in inflammatory response;GO:1900273|positive regulation of long-term synaptic potentiation;GO:1903078|positive regulation of protein localization to plasma membrane;GO:1904646|cellular response to amyloid-beta;GO:1904782|negative regulation of NMDA glutamate receptor activity;GO:1904783|positive regulation of NMDA glutamate receptor activity;GO:2000316|regulation of T-helper 17 type immune response;GO:2000822|regulation of behavioral fear response;","GO:0005654|nucleoplasm;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0030424|axon;GO:0030425|dendrite;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043197|dendritic spine;GO:0043235|receptor complex;GO:0098978|glutamatergic synapse;GO:0099055|integral component of postsynaptic membrane;GO:0099056|integral component of presynaptic membrane;","GO:0001540|amyloid-beta binding;GO:0003674|molecular_function;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0005003|ephrin receptor activity;GO:0005005|transmembrane-ephrin receptor activity;GO:0005102|signaling receptor binding;GO:0005524|ATP binding;GO:0008046|axon guidance receptor activity;GO:0038023|signaling receptor activity;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;","K05111","EPHB2, ERK, DRT; Eph receptor B2 [EC:2.7.10.1]"]
["ENSRNOG00000019474",54,3.473843662,133,8.586727334,0.40455968,-1.305575553,{"v":3.84296e-09,"d":"3.84E-09"},{"v":3.79336e-09,"d":"3.79E-09"},"down","yes","Rsph9","protein_coding","chr9:14840115-14860062:+","gi|564367377|ref|XP_006244600.1|",1350,0,"PREDICTED: radial spoke head protein 9 homolog isoform X1 [Rattus norvegicus]","gi|672064340|ref|XM_006244538.2|",947,0,"PREDICTED: Rattus norvegicus radial spoke head 9 homolog (Chlamydomonas) (Rsph9), transcript variant X1, mRNA","Q9D9V4",509,{"v":1E-176,"d":"1.00E-176"},"Radial spoke head protein 9 homolog",".",".",".",".","pfam04712","Radial_spoke","Radial spokehead-like protein. This family includes the radial spoke head proteins RSP4 and RSP6 from Chlamydomonas reinhardtii, and several eukaryotic homologues, including mammalian RSHL1, the protein product of a familial ciliary dyskinesia candidate gene.","GO:0003341|cilium movement;GO:0035082|axoneme assembly;GO:0044458|motile cilium assembly;GO:0060294|cilium movement involved in cell motility;GO:1904158|axonemal central apparatus assembly;","GO:0001534|radial spoke;GO:0005930|axoneme;GO:0031514|motile cilium;GO:0097729|9+2 motile cilium;",".","K19757","RSPH9; radial spoke head protein 9"]
["ENSRNOG00000007420",0,0.032165219,32,2.065979509,0.015568992,-6.005180619,{"v":3.94143e-09,"d":"3.94E-09"},{"v":3.88585e-09,"d":"3.89E-09"},"down","yes","Hrh1","protein_coding","chr4:147645995-147647455:+","gi|149036950|gb|EDL91568.1|",2520,0,"rCG56382, isoform CRA_b [Rattus norvegicus]","gi|8393563|ref|NM_017018.1|",1449,0,"Rattus norvegicus histamine receptor H 1 (Hrh1), mRNA","P31390",972,0,"Histamine H1 receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0007187|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007199|G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger;GO:0007268|chemical synaptic transmission;GO:0007613|memory;GO:0008542|visual learning;GO:0009629|response to gravity;GO:0010894|negative regulation of steroid biosynthetic process;GO:0043114|regulation of vascular permeability;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0045907|positive regulation of vasoconstriction;GO:0048167|regulation of synaptic plasticity;GO:0048245|eosinophil chemotaxis;GO:0071420|cellular response to histamine;GO:0098664|G protein-coupled serotonin receptor signaling pathway;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0045202|synapse;","GO:0004969|histamine receptor activity;GO:0004993|G protein-coupled serotonin receptor activity;GO:0030594|neurotransmitter receptor activity;GO:0051381|histamine binding;","K04149","HRH1; histamine receptor H1"]
["ENSRNOG00000066887",83,5.339426369,176,11.3628873,0.469900495,-1.089572807,{"v":4.3302e-09,"d":"4.33E-09"},{"v":4.25738E-9,"d":"4.26E-09"},"down","yes","ENSRNOG00000066887","lncRNA","chr1:38624474-38691338:-","gi|564305004|ref|XP_006225271.1|",300,{"v":1E-25,"d":"1.00E-25"},"PREDICTED: CD99 antigen-like protein 2 isoform X2 [Rattus norvegicus]","gi|672012664|ref|XR_598628.1|",3163,0,"PREDICTED: Rattus norvegicus rho GTPase-activating protein 20-like (LOC102556805), transcript variant X3, misc_RNA","Q8BIF0",107,{"v":1e-23,"d":"1.00E-23"},"CD99 antigen-like protein 2",".",".",".",".","pfam12301","CD99L2","CD99 antigen like protein 2. This family of proteins is found in eukaryotes. Proteins in this family are typically between 165 and 237 amino acids in length. CD99L2 and CD99 are involved in trans-endothelial migration of neutrophils in vitro and in the recruitment of neutrophils into inflamed peritoneum.",".",".",".",".","."]
["ENSRNOG00000068478",2,0.128660876,35,2.259665088,0.056938029,-4.134463636,{"v":4.58859e-09,"d":"4.59E-09"},{"v":4.50522e-09,"d":"4.51E-09"},"down","yes","ENSRNOG00000068478","lncRNA","chr18:28310560-28314123:+","gi|148701441|gb|EDL33388.1|",134,7e-07,"mCG1045525, partial [Mus musculus]","gi|22539286|gb|AC115631.4|",315,{"v":3E-162,"d":"3.00E-162"},"Mus musculus BAC clone RP24-128K6 from 18, complete sequence",".",".",".",".",".",".",".",".","pfam11060","DUF2861","Protein of unknown function (DUF2861). This bacterial family of proteins has no known function.",".",".",".",".","."]
["ENSRNOG00000024905",7,0.450313067,48,3.098969263,0.145310595,-2.782788198,{"v":5.23561e-09,"d":"5.24E-09"},{"v":5.12024e-09,"d":"5.12E-09"},"down","yes","Drc1","protein_coding","chr6:26025005-26059414:-","gi|55741506|ref|NP_001007010.1|",3483,0,"dynein regulatory complex protein 1 [Rattus norvegicus]","gi|55741505|ref|NM_001007009.1|",2454,0,"Rattus norvegicus dynein regulatory complex subunit 1 (Drc1), mRNA","Q5XI65",1346,0,"Dynein regulatory complex protein 1",".",".",".",".","pfam14772","NYD-SP28","Sperm tail. NYD-SP28 is expressed in a development-dependent manner, localized in spermatogenic cell cytoplams and human spermatozoa tail. It is post-translationally modified during sperm capacitation and ultimately contributes to the success of fertilisation.","GO:0003352|regulation of cilium movement;GO:0007368|determination of left/right symmetry;GO:0007507|heart development;GO:0060285|cilium-dependent cell motility;GO:0070286|axonemal dynein complex assembly;","GO:0005829|cytosol;GO:0005858|axonemal dynein complex;GO:0005930|axoneme;GO:0031514|motile cilium;",".","K19754","DRC1; dynein regulatry complex protein 1"]
["ENSRNOG00000002922",52,3.345182786,129,8.328479896,0.401655864,-1.315968157,{"v":5.3081e-09,"d":"5.31E-09"},{"v":5.18669E-9,"d":"5.19E-09"},"down","yes","Adora2b","protein_coding","chr10:46940384-46956772:+","gi|149052881|gb|EDM04698.1|",1602,0,"adenosine A2B receptor [Rattus norvegicus]","gi|171847369|gb|BC161854.1|",1850,0,"Rattus norvegicus adenosine A2B receptor, mRNA (cDNA clone MGC:187380 IMAGE:9024632), complete cds","P29276",621,0,"Adenosine receptor A2b",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001938|positive regulation of endothelial cell proliferation;GO:0001973|adenosine receptor signaling pathway;GO:0002882|positive regulation of chronic inflammatory response to non-antigenic stimulus;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0010595|positive regulation of endothelial cell migration;GO:0010701|positive regulation of norepinephrine secretion;GO:0010753|positive regulation of cGMP-mediated signaling;GO:0010893|positive regulation of steroid biosynthetic process;GO:0010906|regulation of glucose metabolic process;GO:0031284|positive regulation of guanylate cyclase activity;GO:0031668|cellular response to extracellular stimulus;GO:0032722|positive regulation of chemokine production;GO:0032755|positive regulation of interleukin-6 production;GO:0032966|negative regulation of collagen biosynthetic process;GO:0033605|positive regulation of catecholamine secretion;GO:0042311|vasodilation;GO:0043306|positive regulation of mast cell degranulation;GO:0043950|positive regulation of cAMP-mediated signaling;GO:0060087|relaxation of vascular smooth muscle;GO:1990776|response to angiotensin;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0045202|synapse;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098978|glutamatergic synapse;","GO:0001609|G protein-coupled adenosine receptor activity;GO:0004930|G protein-coupled receptor activity;","K04267","ADORA2B; adenosine receptor A2b"]
["ENSRNOG00000063438",1,0.064330438,32,2.065979509,0.031137985,-5.005180619,{"v":5.38891e-09,"d":"5.39E-09"},{"v":5.26205e-09,"d":"5.26E-09"},"down","yes","ENSRNOG00000063438","lncRNA","chr10:45823662-45824830:-",".",".",".",".","gi|672024839|ref|XM_008774973.1|",1169,0,"PREDICTED: Rattus norvegicus tumor necrosis factor receptor superfamily, member 13B (Tnfrsf13b), mRNA",".",".",".",".",".",".",".",".","pfam09570","RE_SinI","SinI restriction endonuclease. This family includes the SinI (recognizes and cleaves G^GWCC) restriction endonuclease.",".",".",".",".","."]
["ENSRNOG00000063508",1,0.064330438,32,2.065979509,0.031137985,-5.005180619,{"v":5.38891e-09,"d":"5.39E-09"},{"v":5.26205e-09,"d":"5.26E-09"},"down","yes","ENSRNOG00000063508","protein_coding","chr17:45622444-45643353:-","gi|135527|sp|P06335.1|TCC4_MOUSE",665,{"v":1e-85,"d":"1.00E-85"},"RecName: Full=T-cell receptor gamma chain C region 5/10-13","gi|388240393|dbj|AP012433.1|",331,{"v":1e-171,"d":"1.00E-171"},"Rattus norvegicus DNA, BAC clone: RNB1-056G15, strain: F344/Stm, complete sequence","P06335",260,{"v":3e-87,"d":"3.00E-87"},"T-cell receptor gamma chain C region 5/10-13",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.",".",".",".",".","."]
["ENSRNOG00000015419",20,1.286608764,75,4.842139474,0.265710802,-1.912071215,{"v":5.46757E-9,"d":"5.47E-09"},{"v":5.33521e-09,"d":"5.34E-09"},"down","yes","Spem1","protein_coding","chr10:54541471-54546131:-","gi|157820813|ref|NP_001103123.1|",992,{"v":2e-124,"d":"2.00E-124"},"spermatid maturation protein 1 [Rattus norvegicus]","gi|16758897|ref|NM_053992.1|",1497,0,"Rattus norvegicus neuroligin 2 (Nlgn2), mRNA","Q5F289",335,{"v":2e-106,"d":"2.00E-106"},"Spermatid maturation protein 1",".",".",".",".","pfam14011","ESX-1_EspG","EspG family. This family of proteins contains the the EspG1, EspG2 and EspG3 proteins from M. tuberculosis. These proteins are involved in the ESAT-6 secretion system 1 (ESX-1) of Mycobacterium tuberculosis which is important for virulence and intercellular spread. Proteins in this family are typically between 254 and 295 amino acids in length.","GO:0007283|spermatogenesis;GO:0007291|sperm individualization;GO:0030317|flagellated sperm motility;","GO:0005737|cytoplasm;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000020719",19,1.222278326,73,4.713015755,0.259341023,-1.947077665,{"v":5.74908e-09,"d":"5.75E-09"},{"v":5.60895e-09,"d":"5.61E-09"},"down","yes","Hrc","protein_coding","chr1:95813253-95816984:+","gi|149055945|gb|EDM07376.1|",2378,0,"histidine rich calcium binding protein, isoform CRA_b [Rattus norvegicus]","gi|298894331|emb|FQ224148.1|",2379,0,"Rattus norvegicus TL0ACA75YF06 mRNA sequence","P16230",219,{"v":1E-58,"d":"1.00E-58"},"Sarcoplasmic reticulum histidine-rich calcium-binding protein",".",".",".",".","pfam15449","Retinal","Retinal protein. This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.","GO:0002027|regulation of heart rate;GO:0008016|regulation of heart contraction;GO:0010460|positive regulation of heart rate;GO:0010880|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0033135|regulation of peptidyl-serine phosphorylation;GO:0045823|positive regulation of heart contraction;GO:0051480|regulation of cytosolic calcium ion concentration;GO:0051481|negative regulation of cytosolic calcium ion concentration;GO:0055074|calcium ion homeostasis;GO:0060314|regulation of ryanodine-sensitive calcium-release channel activity;GO:1901844|regulation of cell communication by electrical coupling involved in cardiac conduction;GO:1901899|positive regulation of relaxation of cardiac muscle;GO:1902081|negative regulation of calcium ion import into sarcoplasmic reticulum;GO:1903169|regulation of calcium ion transmembrane transport;","GO:0005575|cellular_component;GO:0030018|Z disc;GO:0033017|sarcoplasmic reticulum membrane;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;GO:0044325|ion channel binding;GO:0051117|ATPase binding;","K23450","HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein"]
["ENSRNOG00000023858",12,0.771965258,59,3.80914972,0.202660781,-2.302861168,{"v":5.80774e-09,"d":"5.81E-09"},{"v":5.66424e-09,"d":"5.66E-09"},"down","yes","Prss39","protein_coding","chr9:36707328-36713001:+","gi|61557348|ref|NP_001013244.1|",1784,0,"serine protease 40 precursor [Rattus norvegicus]","gi|61557347|ref|NM_001013226.1|",1565,0,"Rattus norvegicus protease, serine, 39 (Prss39), mRNA","Q6AXZ6",691,0,"Serine protease 40","mlr3307",88.6,{"v":2e-18,"d":"2.00E-18"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;","GO:0001669|acrosomal vesicle;","GO:0004252|serine-type endopeptidase activity;",".","."]
["ENSRNOG00000025987",0,0.032165219,31,2.001417649,0.016071218,-5.95937693,{"v":6.80977e-09,"d":"6.81E-09"},{"v":6.61891e-09,"d":"6.62E-09"},"down","yes","ENSRNOG00000025987","protein_coding","chr13:47630003-47665394:-","gi|114145724|ref|NP_001041391.1|",4842,0,"uncharacterized protein LOC498236 [Rattus norvegicus]","gi|672074128|ref|XM_008769565.1|",3102,0,"PREDICTED: Rattus norvegicus LRRGT00186 (LOC498236), transcript variant X1, mRNA","Q68CQ1",107,{"v":4e-22,"d":"4.00E-22"},"Maestro heat-like repeat-containing protein family member 7",".",".",".",".","pfam06046","Sec6","Exocyst complex component Sec6. Sec6 is a component of the multiprotein exocyst complex. Sec6 interacts with Sec8, Sec10 and Exo70.These exocyst proteins localize to regions of active exocytosis-at the growing ends of interphase cells and in the medial region of cells undergoing cytokinesis-in an F-actin-dependent and exocytosis- independent manner.",".",".",".",".","."]
["ENSRNOG00000056580",6,0.385982629,45,2.905283684,0.132855401,-2.912071215,{"v":7.22221E-9,"d":"7.22E-09"},{"v":7.00905e-09,"d":"7.01E-09"},"down","yes","En1","protein_coding","chr13:31751545-31755943:+","gi|672073973|ref|XP_001056699.3|",1078,{"v":6e-140,"d":"6.00E-140"},"PREDICTED: LOW QUALITY PROTEIN: homeobox protein engrailed-1 isoform X2 [Rattus norvegicus]","gi|672073972|ref|XM_001056699.6|",1345,0,"PREDICTED: Rattus norvegicus engrailed homeobox 1 (En1), transcript variant X2, mRNA","P09065",414,{"v":2e-139,"d":"2.00E-139"},"Homeobox protein engrailed-1",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0008344|adult locomotory behavior;GO:0009953|dorsal/ventral pattern formation;GO:0009954|proximal/distal pattern formation;GO:0010468|regulation of gene expression;GO:0021549|cerebellum development;GO:0030182|neuron differentiation;GO:0030326|embryonic limb morphogenesis;GO:0030901|midbrain development;GO:0030902|hindbrain development;GO:0030917|midbrain-hindbrain boundary development;GO:0035115|embryonic forelimb morphogenesis;GO:0035176|social behavior;GO:0035264|multicellular organism growth;GO:0042220|response to cocaine;GO:0042756|drinking behavior;GO:0043473|pigmentation;GO:0043524|negative regulation of neuron apoptotic process;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048666|neuron development;GO:0060173|limb development;GO:0061743|motor learning;GO:1901215|negative regulation of neuron death;GO:1990403|embryonic brain development;","GO:0005634|nucleus;GO:0016020|membrane;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:1990837|sequence-specific double-stranded DNA binding;","K09319","EN; homeobox protein engrailed"]
["ENSRNOG00000000239",87,5.596748122,180,11.62113474,0.481600829,-1.05409022,{"v":7.49347e-09,"d":"7.49E-09"},{"v":7.26737e-09,"d":"7.27E-09"},"down","yes","Ccl7","protein_coding","chr10:67016446-67018303:+","gi|56090537|ref|NP_001007613.1|",447,{"v":1E-52,"d":"1.00E-52"},"C-C motif chemokine 7 precursor [Rattus norvegicus]","gi|56090536|ref|NM_001007612.1|",807,0,"Rattus norvegicus chemokine (C-C motif) ligand 7 (Ccl7), mRNA","Q9QXY8",176,{"v":4e-54,"d":"4.00E-54"},"C-C motif chemokine 7",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0002548|monocyte chemotaxis;GO:0006954|inflammatory response;GO:0007010|cytoskeleton organization;GO:0007186|G protein-coupled receptor signaling pathway;GO:0008360|regulation of cell shape;GO:0010332|response to gamma radiation;GO:0030335|positive regulation of cell migration;GO:0030593|neutrophil chemotaxis;GO:0043547|positive regulation of GTPase activity;GO:0048245|eosinophil chemotaxis;GO:0048247|lymphocyte chemotaxis;GO:0070098|chemokine-mediated signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071361|cellular response to ethanol;GO:2000503|positive regulation of natural killer cell chemotaxis;","GO:0005615|extracellular space;","GO:0008009|chemokine activity;GO:0008201|heparin binding;GO:0031726|CCR1 chemokine receptor binding;GO:0031727|CCR2 chemokine receptor binding;GO:0048020|CCR chemokine receptor binding;","K05509","CCL7; C-C motif chemokine 7"]
["ENSRNOG00000005370",10,0.643304382,54,3.486340421,0.18452139,-2.438140027,{"v":8.38121e-09,"d":"8.38E-09"},{"v":8.11042e-09,"d":"8.11E-09"},"down","yes","S1pr4","protein_coding","chr7:8208098-8211893:+","gi|157823827|ref|NP_001101545.1|",1752,0,"sphingosine 1-phosphate receptor 4 [Rattus norvegicus]","gi|157823826|ref|NM_001108075.1|",1270,0,"Rattus norvegicus sphingosine-1-phosphate receptor 4 (S1pr4), mRNA","Q9Z0L1",591,0,"Sphingosine 1-phosphate receptor 4",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0003376|sphingosine-1-phosphate receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0019222|regulation of metabolic process;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0038036|sphingosine-1-phosphate receptor activity;","K04293","S1PR4, EDG6; sphingosine 1-phosphate receptor 4"]
["ENSRNOG00000012278",2,0.128660876,34,2.195103228,0.058612677,-4.092643461,{"v":8.39846e-09,"d":"8.40E-09"},{"v":8.12436e-09,"d":"8.12E-09"},"down","yes","Fgf10","protein_coding","chr2:50800992-50876866:+","gi|6978837|ref|NP_037083.1|",983,{"v":1e-122,"d":"1.00E-122"},"fibroblast growth factor 10 precursor [Rattus norvegicus]","gi|26337204|dbj|AK045267.1|",1871,0,"Mus musculus 9.5 days embryo parthenogenote cDNA, RIKEN full-length enriched library, clone:B130053I21 product:fibroblast growth factor 10, full insert sequence","P70492",383,{"v":4e-124,"d":"4.00E-124"},"Fibroblast growth factor 10",".",".",".",".","pfam00167","FGF","Fibroblast growth factor. Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide range of contexts. They are found in a wide range of organisms, from nematodes to humans. Most share an internal core region of high similarity, conserved residues in which are involved in binding with their receptors. On binding, they cause dimerization of their tyrosine kinase receptors leading to intracellular signalling. There are currently four known tyrosine kinase receptors for fibroblast growth factors. These receptors can each bind several different members of this family. Members of this family have a beta trefoil structure. Most have N-terminal signal peptides and are secreted. A few lack signal sequences but are secreted anyway; still others also lack the signal peptide but are found on the cell surface and within the extracellular matrix. A third group remain intracellular. They have central roles in development, regulating cell proliferation, migration and differentiation. On the other hand, they are important in tissue repair following injury in adult organisms.","GO:0000132|establishment of mitotic spindle orientation;GO:0001525|angiogenesis;GO:0001656|metanephros development;GO:0001759|organ induction;GO:0001823|mesonephros development;GO:0001934|positive regulation of protein phosphorylation;GO:0001974|blood vessel remodeling;GO:0003338|metanephros morphogenesis;GO:0006935|chemotaxis;GO:0007267|cell-cell signaling;GO:0007368|determination of left/right symmetry;GO:0007431|salivary gland development;GO:0007435|salivary gland morphogenesis;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0008543|fibroblast growth factor receptor signaling pathway;GO:0008544|epidermis development;GO:0008589|regulation of smoothened signaling pathway;GO:0009880|embryonic pattern specification;GO:0009887|animal organ morphogenesis;GO:0010468|regulation of gene expression;GO:0010628|positive regulation of gene expression;GO:0010634|positive regulation of epithelial cell migration;GO:0010838|positive regulation of keratinocyte proliferation;GO:0014070|response to organic cyclic compound;GO:0021983|pituitary gland development;GO:0030154|cell differentiation;GO:0030177|positive regulation of Wnt signaling pathway;GO:0030324|lung development;GO:0030334|regulation of cell migration;GO:0030538|embryonic genitalia morphogenesis;GO:0030855|epithelial cell differentiation;GO:0030878|thyroid gland development;GO:0030916|otic vesicle formation;GO:0030949|positive regulation of vascular endothelial growth factor receptor signaling pathway;GO:0031016|pancreas development;GO:0031069|hair follicle morphogenesis;GO:0031076|embryonic camera-type eye development;GO:0031532|actin cytoskeleton reorganization;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0032781|positive regulation of ATPase activity;GO:0032808|lacrimal gland development;GO:0032925|regulation of activin receptor signaling pathway;GO:0034394|protein localization to cell surface;GO:0035019|somatic stem cell population maintenance;GO:0035108|limb morphogenesis;GO:0035265|organ growth;GO:0042060|wound healing;GO:0042246|tissue regeneration;GO:0042472|inner ear morphogenesis;GO:0042475|odontogenesis of dentin-containing tooth;GO:0042693|muscle cell fate commitment;GO:0043410|positive regulation of MAPK cascade;GO:0045596|negative regulation of cell differentiation;GO:0045739|positive regulation of DNA repair;GO:0045747|positive regulation of Notch signaling pathway;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045931|positive regulation of mitotic cell cycle;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046579|positive regulation of Ras protein signal transduction;GO:0046877|regulation of saliva secretion;GO:0048146|positive regulation of fibroblast proliferation;GO:0048286|lung alveolus development;GO:0048514|blood vessel morphogenesis;GO:0048536|spleen development;GO:0048538|thymus development;GO:0048557|embryonic digestive tract morphogenesis;GO:0048565|digestive tract development;GO:0048566|embryonic digestive tract development;GO:0048645|animal organ formation;GO:0048730|epidermis morphogenesis;GO:0048752|semicircular canal morphogenesis;GO:0048754|branching morphogenesis of an epithelial tube;GO:0048807|female genitalia morphogenesis;GO:0048808|male genitalia morphogenesis;GO:0050671|positive regulation of lymphocyte proliferation;GO:0050673|epithelial cell proliferation;GO:0050674|urothelial cell proliferation;GO:0050677|positive regulation of urothelial cell proliferation;GO:0050679|positive regulation of epithelial cell proliferation;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050872|white fat cell differentiation;GO:0050918|positive chemotaxis;GO:0050930|induction of positive chemotaxis;GO:0051145|smooth muscle cell differentiation;GO:0051549|positive regulation of keratinocyte migration;GO:0051726|regulation of cell cycle;GO:0060019|radial glial cell differentiation;GO:0060173|limb development;GO:0060174|limb bud formation;GO:0060425|lung morphogenesis;GO:0060428|lung epithelium development;GO:0060430|lung saccule development;GO:0060436|bronchiole morphogenesis;GO:0060441|epithelial tube branching involved in lung morphogenesis;GO:0060445|branching involved in salivary gland morphogenesis;GO:0060447|bud outgrowth involved in lung branching;GO:0060449|bud elongation involved in lung branching;GO:0060496|mesenchymal-epithelial cell signaling involved in lung development;GO:0060510|type II pneumocyte differentiation;GO:0060513|prostatic bud formation;GO:0060541|respiratory system development;GO:0060594|mammary gland specification;GO:0060595|fibroblast growth factor receptor signaling pathway involved in mammary gland specification;GO:0060615|mammary gland bud formation;GO:0060661|submandibular salivary gland formation;GO:0060664|epithelial cell proliferation involved in salivary gland morphogenesis;GO:0060665|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling;GO:0060667|branch elongation involved in salivary gland morphogenesis;GO:0060879|semicircular canal fusion;GO:0060915|mesenchymal cell differentiation involved in lung development;GO:0061033|secretion by lung epithelial cell involved in lung growth;GO:0061115|lung proximal/distal axis specification;GO:0070075|tear secretion;GO:0070352|positive regulation of white fat cell proliferation;GO:0070371|ERK1 and ERK2 cascade;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070384|Harderian gland development;GO:0071338|positive regulation of hair follicle cell proliferation;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:1900087|positive regulation of G1/S transition of mitotic cell cycle;GO:2001240|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0062023|collagen-containing extracellular matrix;","GO:0005104|fibroblast growth factor receptor binding;GO:0005111|type 2 fibroblast growth factor receptor binding;GO:0008083|growth factor activity;GO:0008201|heparin binding;GO:0042056|chemoattractant activity;","K04358","FGF; fibroblast growth factor"]
["ENSRNOG00000025297",61,3.924156729,141,9.103222211,0.431073376,-1.213994634,{"v":1.00341E-8,"d":"1.00E-08"},{"v":9.6661e-09,"d":"9.67E-09"},"down","yes","Gpr171","protein_coding","chr2:143359564-143366698:-","gi|157824140|ref|NP_001102980.1|",1639,0,"probable G-protein coupled receptor 171 [Rattus norvegicus]","gi|157824139|ref|NM_001109510.1|",1640,0,"Rattus norvegicus G protein-coupled receptor 171 (Gpr171), mRNA","Q8BG55",585,0,"Probable G-protein coupled receptor 171",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0035589|G protein-coupled purinergic nucleotide receptor signaling pathway;GO:0045638|negative regulation of myeloid cell differentiation;","GO:0016021|integral component of membrane;","GO:0045028|G protein-coupled purinergic nucleotide receptor activity;","K08441","GPR171; G protein-coupled receptor 171"]
["ENSRNOG00000021484",65,4.181478482,147,9.490593369,0.440591891,-1.182485151,{"v":1.00345E-8,"d":"1.00E-08"},{"v":9.6661e-09,"d":"9.67E-09"},"down","yes","AABR07003537.1","protein_coding","chr1:106622141-106623699:+","gi|16758286|ref|NP_445974.1|",1016,{"v":3e-138,"d":"3.00E-138"},"rho-related GTP-binding protein RhoQ precursor [Rattus norvegicus]","gi|672036833|ref|XR_590192.1|",593,0,"PREDICTED: Rattus norvegicus rho-related GTP-binding protein RhoQ-like (LOC100911716), misc_RNA","Q9JJL4",395,{"v":1E-139,"d":"1.00E-139"},"Rho-related GTP-binding protein RhoQ","SPAC110.03",248,{"v":3e-82,"d":"3.00E-82"},"COG1100","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.",".",".",".",".","."]
["ENSRNOG00000004390",0,0.032165219,30,1.93685579,0.016606925,-5.912071215,{"v":1.1799E-8,"d":"1.18E-08"},{"v":1.13142E-8,"d":"1.13E-08"},"down","yes","Alx1","protein_coding","chr7:38147117-38177220:-","gi|6978601|ref|NP_037053.1|",1779,0,"ALX homeobox protein 1 [Rattus norvegicus]","gi|6978600|ref|NM_012921.1|",1727,0,"Rattus norvegicus ALX homeobox 1 (Alx1), mRNA","Q63087",689,0,"ALX homeobox protein 1","ECU03g1170",52,1e-06,"COG5576","pfam00046","Homeobox","Homeobox domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001501|skeletal system development;GO:0001755|neural crest cell migration;GO:0001843|neural tube closure;GO:0006357|regulation of transcription by RNA polymerase II;GO:0009952|anterior/posterior pattern specification;GO:0010718|positive regulation of epithelial to mesenchymal transition;GO:0014031|mesenchymal cell development;GO:0030326|embryonic limb morphogenesis;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048704|embryonic skeletal system morphogenesis;GO:0060021|roof of mouth development;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005794|Golgi apparatus;GO:0016604|nuclear body;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0042803|protein homodimerization activity;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09334","ALX1, CART1; ALX homeobox protein 1"]
["ENSRNOG00000017689",0,0.032165219,30,1.93685579,0.016606925,-5.912071215,{"v":1.1799E-8,"d":"1.18E-08"},{"v":1.13142E-8,"d":"1.13E-08"},"down","yes","Itih3","protein_coding","chr16:6101930-6116924:-","gi|672079321|ref|XP_008769224.1|",4719,0,"PREDICTED: inter-alpha-trypsin inhibitor heavy chain H3 isoform X2 [Rattus norvegicus]","gi|672079320|ref|XM_008771002.1|",2806,0,"PREDICTED: Rattus norvegicus inter-alpha trypsin inhibitor, heavy chain 3 (Itih3), transcript variant X2, mRNA","Q63416",1756,0,"Inter-alpha-trypsin inhibitor heavy chain H3","alr4412",86.7,{"v":2E-16,"d":"2.00E-16"},"COG2304","pfam06668","ITI_HC_C","Inter-alpha-trypsin inhibitor heavy chain C-terminus. This family represents the C-terminal region of inter-alpha-trypsin inhibitor heavy chains. Inter-alpha-trypsin inhibitors are glycoproteins with a high inhibitory activity against trypsin, built up from different combinations of four polypeptides: bikunin and the three heavy chains that belong to this family (HC1, HC2, HC3). The heavy chains do not have any protease inhibitory properties but have the capacity to interact in vitro and in vivo with hyaluronic acid, which promotes the stability of the extra-cellular matrix. All family members contain the pfam00092 domain.","GO:0010951|negative regulation of endopeptidase activity;GO:0030212|hyaluronan metabolic process;","GO:0005576|extracellular region;","GO:0004867|serine-type endopeptidase inhibitor activity;","K24513","ITIH3, SHAP; inter-alpha-trypsin inhibitor heavy chain H3"]
["ENSRNOG00000065552",4,0.257321753,39,2.517912527,0.102196462,-3.290582838,{"v":1.19899E-8,"d":"1.20E-08"},{"v":1.14876E-8,"d":"1.15E-08"},"down","yes","ENSRNOG00000065552","protein_coding","chr6:100024869-100028318:+","gi|62821834|ref|NP_001017383.1|",1469,0,"peptidyl-prolyl cis-trans isomerase-like 2 [Rattus norvegicus]","gi|672071763|ref|XM_008768892.1|",775,0,"PREDICTED: Rattus norvegicus peptidylprolyl isomerase (cyclophilin)-like 2 (Ppil2), transcript variant X1, mRNA","Q9D787",569,0,"RING-type E3 ubiquitin-protein ligase PPIL2","SPAC21E11.05c",188,{"v":1E-52,"d":"1.00E-52"},"COG0652","pfam00160","Pro_isomerase","Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD. The peptidyl-prolyl cis-trans isomerases, also known as cyclophilins, share this domain of about 109 amino acids. Cyclophilins have been found in all organisms studied so far and catalyse peptidyl-prolyl isomerization during which the peptide bond preceding proline (the peptidyl-prolyl bond) is stabilized in the cis conformation. Mammalian cyclophilin A (CypA) is a major cellular target for the immunosuppressive drug cyclosporin A (CsA). Other roles for cyclophilins may include chaperone and cell signalling function.",".",".",".",".","."]
["ENSRNOG00000029071",33,2.12290446,96,6.197938527,0.342517831,-1.545749001,{"v":1.31653E-8,"d":"1.32E-08"},{"v":1.25801E-8,"d":"1.26E-08"},"down","yes","Unc5c","protein_coding","chr2:230180951-230535217:+","gi|148680122|gb|EDL12069.1|",5035,0,"unc-5 homolog C (C. elegans), isoform CRA_b, partial [Mus musculus]","gi|672044265|ref|XM_006233402.2|",8537,0,"PREDICTED: Rattus norvegicus unc-5 homolog C (C. elegans) (Unc5c), transcript variant X1, mRNA","Q761X5",1832,0,"Netrin receptor UNC5C",".",".",".",".","pfam00791","ZU5","ZU5 domain. Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.","GO:0006915|apoptotic process;GO:0007411|axon guidance;GO:0007420|brain development;GO:0030334|regulation of cell migration;GO:0033564|anterior/posterior axon guidance;GO:0038007|netrin-activated signaling pathway;GO:0043065|positive regulation of apoptotic process;GO:0061643|chemorepulsion of axon;GO:1990791|dorsal root ganglion development;","GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0030027|lamellipodium;GO:0030175|filopodium;GO:0030424|axon;GO:0030425|dendrite;GO:0030426|growth cone;GO:0043025|neuronal cell body;GO:0045202|synapse;","GO:0005042|netrin receptor activity;GO:0005043|netrin receptor activity involved in chemorepulsion;GO:0015631|tubulin binding;GO:0019901|protein kinase binding;","K07521","UNC5; netrin receptor unc-5"]
["ENSRNOG00000026217",35,2.251565336,99,6.391624106,0.352268109,-1.505254222,{"v":1.51019E-8,"d":"1.51E-08"},{"v":1.43824e-08,"d":"1.44E-08"},"down","yes","Armc2","protein_coding","chr20:45394127-45504819:-","gi|564398283|ref|XP_574794.3|",4452,0,"PREDICTED: armadillo repeat-containing protein 2 isoform X2 [Rattus norvegicus]","gi|672086772|ref|XM_574794.4|",2951,0,"PREDICTED: Rattus norvegicus armadillo repeat containing 2 (Armc2), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam15449","Retinal","Retinal protein. This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.","GO:0007288|sperm axoneme assembly;GO:0044782|cilium organization;",".",".","K24123","ARMC2; armadillo repeat-containing protein 2"]
["ENSRNOG00000006705",43,2.766208842,112,7.230928281,0.382552383,-1.386270787,{"v":1.512e-08,"d":"1.51E-08"},{"v":1.43949E-8,"d":"1.44E-08"},"down","yes","Mkks","protein_coding","chr3:124201877-124220162:-","gi|56605782|ref|NP_001008354.1|",3008,0,"mcKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin [Rattus norvegicus]","gi|558757399|ref|NM_001008353.2|",2953,0,"Rattus norvegicus McKusick-Kaufman syndrome (Mkks), mRNA","Q9JI70",1065,0,"McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin","MTH794",88.6,{"v":3e-17,"d":"3.00E-17"},"COG0459","pfam00118","Cpn60_TCP1","TCP-1/cpn60 chaperonin family. This family includes members from the HSP60 chaperone family and the TCP-1 (T-complex protein) family.","GO:0006457|protein folding;GO:0007286|spermatid development;GO:0007608|sensory perception of smell;GO:0008150|biological_process;GO:0010629|negative regulation of gene expression;GO:0014824|artery smooth muscle contraction;GO:0021756|striatum development;GO:0021766|hippocampus development;GO:0021987|cerebral cortex development;GO:0030837|negative regulation of actin filament polymerization;GO:0032502|developmental process;GO:0033210|leptin-mediated signaling pathway;GO:0034260|negative regulation of GTPase activity;GO:0035176|social behavior;GO:0038108|negative regulation of appetite by leptin-mediated signaling pathway;GO:0040018|positive regulation of multicellular organism growth;GO:0042311|vasodilation;GO:0044321|response to leptin;GO:0045444|fat cell differentiation;GO:0045494|photoreceptor cell maintenance;GO:0045776|negative regulation of blood pressure;GO:0046907|intracellular transport;GO:0048854|brain morphogenesis;GO:0050910|detection of mechanical stimulus involved in sensory perception of sound;GO:0051131|chaperone-mediated protein complex assembly;GO:0051216|cartilage development;GO:0051492|regulation of stress fiber assembly;GO:0060271|cilium assembly;GO:0060296|regulation of cilium beat frequency involved in ciliary motility;GO:0060324|face development;GO:1905515|non-motile cilium assembly;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0031514|motile cilium;GO:0036064|ciliary basal body;GO:1902636|kinociliary basal body;","GO:0003674|molecular_function;GO:0005524|ATP binding;GO:0051082|unfolded protein binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;","K09492","MKKS; McKusick-Kaufman syndrome protein"]
["ENSRNOG00000042133",2,0.128660876,33,2.130541369,0.060388819,-4.049574739,{"v":1.53806e-08,"d":"1.54E-08"},{"v":1.46333e-08,"d":"1.46E-08"},"down","yes","AABR07006275.1","protein_coding","chr1:208218000-208236257:+","gi|672014684|ref|XP_008772999.1|",1034,{"v":2e-138,"d":"2.00E-138"},"PREDICTED: LOW QUALITY PROTEIN: membrane-spanning 4-domains subfamily A member 4D-like [Rattus norvegicus]","gi|672014683|ref|XM_008774777.1|",1012,0,"PREDICTED: Rattus norvegicus similar to membrane-spanning 4-domains, subfamily A, member 4C (LOC690862), mRNA","Q99N05",283,{"v":4e-93,"d":"4.00E-93"},"Membrane-spanning 4-domains subfamily A member 4D",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.",".",".",".",".","."]
["ENSRNOG00000042455",2,0.128660876,33,2.130541369,0.060388819,-4.049574739,{"v":1.53806e-08,"d":"1.54E-08"},{"v":1.46333e-08,"d":"1.46E-08"},"down","yes","Tlr12","protein_coding","chr5:140959996-140964816:-","gi|672054117|ref|XP_008762370.1|",3846,0,"PREDICTED: toll-like receptor 12 isoform X1 [Rattus norvegicus]","gi|672054116|ref|XM_008764148.1|",3536,0,"PREDICTED: Rattus norvegicus toll-like receptor 12 (Tlr12), transcript variant X1, mRNA","Q6QNU9",1125,0,"Toll-like receptor 12",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.","GO:0002224|toll-like receptor signaling pathway;GO:0006954|inflammatory response;GO:0045087|innate immune response;","GO:0005887|integral component of plasma membrane;","GO:0003953|NAD+ nucleosidase activity;GO:0004888|transmembrane signaling receptor activity;GO:0038023|signaling receptor activity;","K18807","TLR12; toll-like receptor 12"]
["ENSRNOG00000008560",62,3.988487167,141,9.103222211,0.438140152,-1.190535661,{"v":1.6778E-8,"d":"1.68E-08"},{"v":1.59335e-08,"d":"1.59E-08"},"down","yes","Ccdc30","protein_coding","chr5:132926615-133019659:-","gi|564306014|ref|XP_006225563.1|",3188,0,"PREDICTED: coiled-coil domain-containing protein 30 isoform X1 [Rattus norvegicus]","gi|672019869|ref|XM_006225501.2|",2580,0,"PREDICTED: Rattus norvegicus coiled-coil domain containing 30 (Ccdc30), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam13868","Trichoplein","tumor suppressor, Mitostatin. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs).",".",".",".",".","."]
["ENSRNOG00000062856",5,0.321652191,41,2.647036246,0.121514086,-3.040804529,{"v":1.70578e-08,"d":"1.71E-08"},{"v":1.61832e-08,"d":"1.62E-08"},"down","yes","ENSRNOG00000062856","protein_coding","chr2:52191435-52213981:-","gi|829728330|ref|XP_012628309.1|",928,{"v":8e-160,"d":"8.00E-160"},"PREDICTED: endogenous retrovirus group K member 8 Pol protein [Microcebus murinus]","gi|33354286|gb|AC134265.6|",2395,0,"Rattus norvegicus 13 BAC CH230-151K3 (Children's Hospital Oakland Research Institute) complete sequence","P03364",315,{"v":2e-139,"d":"2.00E-139"},"Gag-Pro-Pol polyprotein",".",".",".",".","pfam00429","TLV_coat","ENV polyprotein (coat polyprotein).",".",".",".",".","."]
["ENSRNOG00000029022",51,3.280852347,124,8.005670597,0.409816056,-1.286951588,{"v":1.85514E-8,"d":"1.86E-08"},{"v":1.75564E-8,"d":"1.76E-08"},"down","yes","Zfp112","protein_coding","chr1:79676839-79691994:+","gi|564326567|ref|XP_006228484.1|",4905,0,"PREDICTED: zinc finger protein 112 isoform X1 [Rattus norvegicus]","gi|672035030|ref|XM_006228422.2|",3465,0,"PREDICTED: Rattus norvegicus zinc finger protein 112 (Zfp112), transcript variant X1, mRNA","Q0VAW7",1207,0,"Zinc finger protein 112",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0046872|metal ion binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSRNOG00000069835",39,2.508887089,105,6.778995264,0.370097189,-1.434023918,{"v":1.88184e-08,"d":"1.88E-08"},{"v":1.78002e-08,"d":"1.78E-08"},"down","yes","Oas1i","protein_coding","chr12:35624592-35636604:+","gi|57527337|ref|NP_001009680.1|",1808,0,"2 ' -5 ' oligoadenylate synthetase 1I [Rattus norvegicus]","gi|672073200|ref|XM_003751197.2|",1648,0,"PREDICTED: Rattus norvegicus 2'-5'-oligoadenylate synthase 1A-like (LOC100910735), mRNA","P11928",555,0,"2'-5'-oligoadenylate synthase 1A",".",".",".",".","pfam10421","OAS1_C","2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus. This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between 320 and 344 at the extreme C-terminal end. Oligoadenylate synthetases are antiviral enzymes that counteract vial attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesize 2'.5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication. This domain is often associated with NTP_transf_2 pfam01909.",".",".",".",".","."]
["ENSRNOG00000063968",0,0.032165219,29,1.87229393,0.017179578,-5.863161614,{"v":2.05034E-8,"d":"2.05E-08"},{"v":1.93364E-8,"d":"1.93E-08"},"down","yes","Olr302","protein_coding","chr1:195387774-195399522:+","gi|149061495|gb|EDM11918.1|",1561,0,"rCG47792 [Rattus norvegicus]","gi|76362887|gb|AC116450.17|",1020,0,"Mus musculus chromosome 7, clone RP24-249O20, complete sequence","Q8NGR1",413,{"v":1e-128,"d":"1.00E-128"},"Olfactory receptor 13A1",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.",".",".",".",".","."]
["ENSRNOG00000011644",10,0.643304382,52,3.357216702,0.191618367,-2.383692243,{"v":2.41802E-8,"d":"2.42E-08"},{"v":2.27027e-08,"d":"2.27E-08"},"down","yes","Slc1a7","protein_coding","chr5:122731003-122775134:+","gi|157817698|ref|NP_001102443.1|",2633,0,"excitatory amino acid transporter 5 [Rattus norvegicus]","gi|157817697|ref|NM_001108973.1|",2786,0,"Rattus norvegicus solute carrier family 1 (glutamate transporter), member 7 (Slc1a7), mRNA","Q8JZR4",963,0,"Excitatory amino acid transporter 5","BH3820",145,{"v":2e-36,"d":"2.00E-36"},"COG1301","pfam00375","SDF","Sodium:dicarboxylate symporter family.","GO:0001504|neurotransmitter uptake;GO:0015813|L-glutamate transmembrane transport;GO:0098656|anion transmembrane transport;GO:0098810|neurotransmitter reuptake;","GO:0005886|plasma membrane;GO:0098978|glutamatergic synapse;GO:0099055|integral component of postsynaptic membrane;GO:0099056|integral component of presynaptic membrane;","GO:0005313|L-glutamate transmembrane transporter activity;GO:0008509|anion transmembrane transporter activity;GO:0015293|symporter activity;","K05618","SLC1A7, EAAT5; solute carrier family 1 (glutamate transporter), member 7"]
["ENSRNOG00000023881",10,0.643304382,52,3.357216702,0.191618367,-2.383692243,{"v":2.41802E-8,"d":"2.42E-08"},{"v":2.27027e-08,"d":"2.27E-08"},"down","yes","Skap1","protein_coding","chr10:81425525-81732650:+","gi|67514574|ref|NP_775433.2|",1509,0,"src kinase-associated phosphoprotein 1 [Rattus norvegicus]","gi|241982901|gb|AC136178.3|",1314,0,"Rattus norvegicus CH230-435P16 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q4V7G1",585,0,"Src kinase-associated phosphoprotein 1",".",".",".",".","pfam00169","PH","PH domain. PH stands for pleckstrin homology.","GO:0001954|positive regulation of cell-matrix adhesion;GO:0002250|adaptive immune response;GO:0002821|positive regulation of adaptive immune response;GO:0033625|positive regulation of integrin activation;GO:0033634|positive regulation of cell-cell adhesion mediated by integrin;GO:0034116|positive regulation of heterotypic cell-cell adhesion;GO:0045785|positive regulation of cell adhesion;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050852|T cell receptor signaling pathway;GO:0072659|protein localization to plasma membrane;GO:1903039|positive regulation of leukocyte cell-cell adhesion;","GO:0001772|immunological synapse;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0032991|protein-containing complex;GO:0042101|T cell receptor complex;GO:0044853|plasma membrane raft;","GO:0005515|protein binding;GO:0019901|protein kinase binding;GO:0019903|protein phosphatase binding;GO:0042169|SH2 domain binding;GO:0044877|protein-containing complex binding;","K17699","SKAP1, SKAP55; src kinase associated phosphoprotein 1"]
["ENSRNOG00000025460",11,0.70763482,54,3.486340421,0.202973529,-2.300636503,{"v":2.59457E-8,"d":"2.59E-08"},{"v":2.43124e-08,"d":"2.43E-08"},"down","yes","Tmem71","protein_coding","chr7:98276975-98315858:-","gi|403420582|ref|NP_001258144.1|",1268,{"v":1E-165,"d":"1.00E-165"},"transmembrane protein 71 [Rattus norvegicus]","gi|403420581|ref|NM_001271215.1|",1206,0,"Rattus norvegicus transmembrane protein 71 (Tmem71), mRNA","Q149F5",449,{"v":3e-150,"d":"3.00E-150"},"Transmembrane protein 71",".",".",".",".","pfam15121","TMEM71","TMEM71 protein family. The function of this family, TMEM71, is not known, however it is predicted to be a transmembrane protein. This family of proteins is found in eukaryotes and located in the cell membrane. Proteins in this family vary between 41 and 291 amino acids in length.",".","GO:0005739|mitochondrion;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000059519",7,0.450313067,45,2.905283684,0.154997968,-2.689678794,{"v":2.79548E-8,"d":"2.80E-08"},{"v":2.61478e-08,"d":"2.61E-08"},"down","yes","Bbox1","protein_coding","chr3:96822655-96871458:-","gi|12018320|ref|NP_072151.1|",2098,0,"gamma-butyrobetaine dioxygenase [Rattus norvegicus]","gi|298881757|emb|FQ210746.1|",2607,0,"Rattus norvegicus TL0ABA23YC02 mRNA sequence","Q9QZU7",812,0,"Gamma-butyrobetaine dioxygenase","mll1440",185,{"v":1E-50,"d":"1.00E-50"},"COG2175","pfam02668","TauD","Taurine catabolism dioxygenase TauD, TfdA family. This family consists of taurine catabolism dioxygenases of the TauD, TfdA family. TauD from Escherichia coli is an alpha-ketoglutarate-dependent taurine dioxygenase. This enzyme catalyses the oxygenolytic release of sulfite from taurine. TfdA from Burkholderia sp. is a 2,4-dichlorophenoxyacetic acid/alpha-ketoglutarate dioxygenase.  TfdA from Alcaligenes eutrophus JMP134 is a 2,4-dichlorophenoxyacetate monooxygenase. Also included are gamma-Butyrobetaine hydroxylase enzymes EC:1.14.11.1.","GO:0045329|carnitine biosynthetic process;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;","GO:0005506|iron ion binding;GO:0008270|zinc ion binding;GO:0008336|gamma-butyrobetaine dioxygenase activity;GO:0042802|identical protein binding;","K00471","BBOX1; gamma-butyrobetaine dioxygenase [EC:1.14.11.1]"]
["ENSRNOG00000063741",7,0.450313067,45,2.905283684,0.154997968,-2.689678794,{"v":2.79548E-8,"d":"2.80E-08"},{"v":2.61478e-08,"d":"2.61E-08"},"down","yes","ENSRNOG00000063741","protein_coding","chr5:57703909-57723062:+","gi|672019262|ref|XP_008774163.1|",185,{"v":1e-12,"d":"1.00E-12"},"PREDICTED: prothymosin alpha-like [Rattus norvegicus]","gi|672019261|ref|XM_008775941.1|",2635,0,"PREDICTED: Rattus norvegicus RGD1560723 (RGD1560723), mRNA",".",".",".",".",".",".",".",".","pfam00607","Gag_p24","gag gene protein p24 (core nucleocapsid protein). p24 forms inner protein layer of the nucleocapsid. ELISA tests for p24 is the most commonly used method to demonstrate virus replication both in vivo and in vitro.",".",".",".",".","."]
["ENSRNOG00000025998",68,4.374469797,148,9.555155229,0.457812531,-1.127171144,{"v":3.14021e-08,"d":"3.14E-08"},{"v":2.92955e-08,"d":"2.93E-08"},"down","yes","Crybg1","protein_coding","chr20:47426183-47621392:-","gi|672086845|ref|XP_008771253.1|",9879,0,"PREDICTED: absent in melanoma 1 protein isoform X2 [Rattus norvegicus]","gi|755532767|ref|XM_006512498.2|",4506,0,"PREDICTED: Mus musculus absent in melanoma 1 (Aim1), transcript variant X1, mRNA","Q9Y4K1",2340,0,"Beta/gamma crystallin domain-containing protein 1",".",".",".",".","pfam00030","Crystall","Beta/Gamma crystallin. The alignment comprises two Greek key motifs since the similarity between them is very low.","GO:0008150|biological_process;","GO:0005575|cellular_component;","GO:0003674|molecular_function;GO:0030246|carbohydrate binding;",".","."]
["ENSRNOG00000014265",1,0.064330438,29,1.87229393,0.034359155,-4.863161614,{"v":3.17823e-08,"d":"3.18E-08"},{"v":2.9626E-8,"d":"2.96E-08"},"down","yes","Tnfrsf19","protein_coding","chr15:35092206-35180795:-","gi|112984440|ref|NP_001037694.1|",2153,0,"tumor necrosis factor receptor superfamily member 19 precursor [Rattus norvegicus]","gi|256221051|ref|NM_013869.5|",1549,0,"Mus musculus tumor necrosis factor receptor superfamily, member 19 (Tnfrsf19), transcript variant 1, mRNA","Q9JLL3",744,0,"Tumor necrosis factor receptor superfamily member 19",".",".",".",".","pfam05287","PMG","PMG protein. This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteristic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.","GO:0001942|hair follicle development;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0046330|positive regulation of JNK cascade;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0038023|signaling receptor activity;","K05155","TNFRSF19, TROY; tumor necrosis factor receptor superfamily member 19"]
["ENSRNOG00000048769",8,0.514643505,47,3.034407404,0.16960264,-2.559769471,{"v":3.30044e-08,"d":"3.30E-08"},{"v":3.07101E-8,"d":"3.07E-08"},"down","yes","Nek5","protein_coding","chr16:69895422-69939429:+","gi|672029530|ref|XP_008771535.1|",2950,0,"PREDICTED: serine/threonine-protein kinase Nek5 [Rattus norvegicus]","gi|141803451|ref|NM_177898.4|",1445,0,"Mus musculus NIMA (never in mitosis gene a)-related expressed kinase 5 (Nek5), mRNA","Q7TSC3",1014,0,"Serine/threonine-protein kinase Nek5",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006468|protein phosphorylation;GO:0051155|positive regulation of striated muscle cell differentiation;GO:2001056|positive regulation of cysteine-type endopeptidase activity;",".","GO:0004672|protein kinase activity;GO:0005524|ATP binding;","K08857","NEK1_4_5; NIMA (never in mitosis gene a)-related kinase 1/4/5 [EC:2.7.11.1]"]
["ENSRNOG00000064154",8,0.514643505,47,3.034407404,0.16960264,-2.559769471,{"v":3.30044e-08,"d":"3.30E-08"},{"v":3.07101E-8,"d":"3.07E-08"},"down","yes","Rassf10","protein_coding","chr1:167058099-167063572:+","gi|26338081|dbj|BAC32726.1|",2163,0,"unnamed protein product [Mus musculus]","gi|54888808|gb|AC110194.11|",3162,0,"Mus musculus chromosome 7, clone RP23-238J3, complete sequence","Q8BL43",747,0,"Ras association domain-containing protein 10",".",".",".",".","pfam00943","Alpha_E2_glycop","Alphavirus E2 glycoprotein. E2 forms a heterodimer with E1. The virus spikes are made up of 80 trimers of these heterodimers (sindbis virus).",".",".",".",".","."]
["ENSRNOG00000002174",0,0.032165219,28,1.80773207,0.017793134,-5.812535541,{"v":3.57365e-08,"d":"3.57E-08"},{"v":3.31927e-08,"d":"3.32E-08"},"down","yes","Cwh43","protein_coding","chr14:34754289-34800814:-","gi|300794217|ref|NP_001178606.1|",3454,0,"PGAP2-interacting protein [Rattus norvegicus]","gi|300794216|ref|NM_001191677.1|",2452,0,"Rattus norvegicus cell wall biogenesis 43 C-terminal homolog (Cwh43), mRNA","Q91YL7",1216,0,"PGAP2-interacting protein",".",".",".",".","pfam03372","Exo_endo_phos","Endonuclease/Exonuclease/phosphatase family. This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins EC:4.2.99.18, DNase I proteins EC:3.1.21.1, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56, Sphingomyelinase EC:3.1.4.12 and Nocturnin.","GO:0006506|GPI anchor biosynthetic process;","GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000016997",0,0.032165219,28,1.80773207,0.017793134,-5.812535541,{"v":3.57365e-08,"d":"3.57E-08"},{"v":3.31927e-08,"d":"3.32E-08"},"down","yes","Bnip5","protein_coding","chr20:6956201-6975091:-","gi|672085908|ref|XP_008771013.1|",2177,0,"PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein C6orf222 homolog isoform X2 [Rattus norvegicus]","gi|146149258|ref|NM_172450.3|",1312,0,"Mus musculus RIKEN cDNA 4930539E08 gene (4930539E08Rik), mRNA",".",".",".",".",".",".",".",".","pfam04484","DUF566","Family of unknown function (DUF566). Family of related proteins that is plant specific.",".",".",".",".","."]
["ENSRNOG00000025946",49,3.152191471,119,7.682861299,0.410288739,-1.285288539,{"v":3.69409e-08,"d":"3.69E-08"},{"v":3.42835e-08,"d":"3.43E-08"},"down","yes","Igf2bp2","protein_coding","chr11:78874414-78974377:+","gi|148665207|gb|EDK97623.1|",2891,0,"insulin-like growth factor 2 mRNA binding protein 2, isoform CRA_d, partial [Mus musculus]","gi|396578131|ref|NM_001270598.1|",3602,0,"Rattus norvegicus insulin-like growth factor 2 mRNA binding protein 2 (Igf2bp2), transcript variant 1, mRNA","Q5SF07",1105,0,"Insulin-like growth factor 2 mRNA-binding protein 2",".",".",".",".","pfam00013","KH_1","KH domain. KH motifs bind RNA in vitro. Autoantibodies to Nova, a KH domain protein, cause paraneoplastic opsoclonus ataxia.","GO:0007399|nervous system development;GO:0010468|regulation of gene expression;GO:0051028|mRNA transport;GO:0051252|regulation of RNA metabolic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005856|cytoskeleton;","GO:0003729|mRNA binding;GO:0003730|mRNA 3'-UTR binding;GO:0048027|mRNA 5'-UTR binding;","K17392","IGF2BP2; insulin-like growth factor 2 mRNA-binding protein 2"]
["ENSRNOG00000002385",44,2.83053928,111,7.166366422,0.394975517,-1.340164867,{"v":3.99307e-08,"d":"3.99E-08"},{"v":3.69982e-08,"d":"3.70E-08"},"down","yes","Prg4","protein_coding","chr13:62487257-62504119:-","gi|728050528|ref|NP_001099432.3|",1970,0,"proteoglycan 4 precursor [Rattus norvegicus]","gi|728050527|ref|NM_001105962.3|",2505,0,"Rattus norvegicus proteoglycan 4 (Prg4), mRNA","Q9JM99",659,0,"Proteoglycan 4",".",".",".",".","pfam01033","Somatomedin_B","Somatomedin B domain.","GO:0006897|endocytosis;GO:0006955|immune response;GO:0032715|negative regulation of interleukin-6 production;GO:0042127|regulation of cell proliferation;GO:0071425|hematopoietic stem cell proliferation;","GO:0005615|extracellular space;","GO:0005044|scavenger receptor activity;GO:0030247|polysaccharide binding;","K24286","PRG4; proteoglycan 4"]
["ENSRNOG00000015353",38,2.444556651,101,6.520747825,0.374889003,-1.415464589,{"v":4.74644e-08,"d":"4.75E-08"},{"v":4.3749e-08,"d":"4.37E-08"},"down","yes","Prss12","protein_coding","chr2:211624134-211684126:+","gi|384950691|sp|G3V801.1|NETR_RAT",3740,0,"RecName: Full=Neurotrypsin; AltName: Full=Serine protease 12; Flags: Precursor","gi|26024220|ref|NM_053504.1|",2475,0,"Rattus norvegicus protease, serine 12 (Prss12), mRNA","G3V801",1445,0,"Neurotrypsin","mlr3307",94.4,{"v":5e-20,"d":"5.00E-20"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;GO:0006887|exocytosis;GO:0006897|endocytosis;GO:0031638|zymogen activation;","GO:0005886|plasma membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0031410|cytoplasmic vesicle;GO:0043083|synaptic cleft;GO:0043195|terminal bouton;GO:0045202|synapse;","GO:0004252|serine-type endopeptidase activity;GO:0005044|scavenger receptor activity;GO:0008233|peptidase activity;","K09624","PRSS12; neurotrypsin [EC:3.4.21.-]"]
["ENSRNOG00000019057",7,0.450313067,44,2.840721825,0.158520649,-2.657257316,{"v":4.86705e-08,"d":"4.87E-08"},{"v":4.48053E-8,"d":"4.48E-08"},"down","yes","Prkcq","protein_coding","chr17:67246394-67378704:-","gi|454515948|ref|NP_001263650.1|",3775,0,"protein kinase C theta type [Rattus norvegicus]","gi|454515947|ref|NM_001276721.1|",3370,0,"Rattus norvegicus protein kinase C, theta (Prkcq), mRNA","Q9WTQ0",1454,0,"Protein kinase C theta type",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0001666|response to hypoxia;GO:0002376|immune system process;GO:0006355|regulation of transcription, DNA-templated;GO:0006468|protein phosphorylation;GO:0006509|membrane protein ectodomain proteolysis;GO:0006954|inflammatory response;GO:0007568|aging;GO:0009408|response to heat;GO:0009749|response to glucose;GO:0010389|regulation of G2/M transition of mitotic cell cycle;GO:0014070|response to organic cyclic compound;GO:0018105|peptidyl-serine phosphorylation;GO:0019229|regulation of vasoconstriction;GO:0030182|neuron differentiation;GO:0032212|positive regulation of telomere maintenance via telomerase;GO:0032740|positive regulation of interleukin-17 production;GO:0032743|positive regulation of interleukin-2 production;GO:0032753|positive regulation of interleukin-4 production;GO:0032868|response to insulin;GO:0035556|intracellular signal transduction;GO:0042102|positive regulation of T cell proliferation;GO:0042246|tissue regeneration;GO:0042307|positive regulation of protein import into nucleus;GO:0045730|respiratory burst;GO:0046627|negative regulation of insulin receptor signaling pathway;GO:0050714|positive regulation of protein secretion;GO:0050870|positive regulation of T cell activation;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051491|positive regulation of filopodium assembly;GO:0051496|positive regulation of stress fiber assembly;GO:0051973|positive regulation of telomerase activity;GO:0060326|cell chemotaxis;GO:0070233|negative regulation of T cell apoptotic process;GO:0090330|regulation of platelet aggregation;GO:1904355|positive regulation of telomere capping;GO:2000318|positive regulation of T-helper 17 type immune response;GO:2000570|positive regulation of T-helper 2 cell activation;","GO:0001772|immunological synapse;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016235|aggresome;GO:0031594|neuromuscular junction;GO:0034451|centriolar satellite;GO:0042383|sarcolemma;","GO:0004674|protein serine/threonine kinase activity;GO:0004697|protein kinase C activity;GO:0004698|calcium-dependent protein kinase C activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0046872|metal ion binding;","K18052","PRKCQ; novel protein kinase C theta type [EC:2.7.11.13]"]
["ENSRNOG00000001342",5,0.321652191,39,2.517912527,0.127745578,-2.968654743,{"v":5.4109e-08,"d":"5.41E-08"},{"v":4.96279e-08,"d":"4.96E-08"},"down","yes","ENSRNOG00000001342","protein_coding","chr12:33261476-33293932:-","gi|672073127|ref|XP_008767497.1|",1641,0,"PREDICTED: WD repeat-containing protein 66 isoform X2 [Rattus norvegicus]","gi|672073126|ref|XM_008769275.1|",1812,0,"PREDICTED: Rattus norvegicus WD repeat domain 66 (Wdr66), transcript variant X2, mRNA","E9Q743",596,0,"Cilia- and flagella-associated protein 251",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.","GO:0030317|flagellated sperm motility;","GO:0036126|sperm flagellum;",".","K24228","WDR66, CFAP251; cilia- and flagella-associated protein 251"]
["ENSRNOG00000001001",1,0.064330438,28,1.80773207,0.035586268,-4.812535541,{"v":5.76529e-08,"d":"5.77E-08"},{"v":5.27851e-08,"d":"5.28E-08"},"down","yes","Retn","protein_coding","chr12:1710881-1712620:+","gi|21426805|ref|NP_653342.1|",290,{"v":3E-28,"d":"3.00E-28"},"resistin precursor [Rattus norvegicus]","gi|49522640|gb|BC074018.1|",1016,0,"Rattus norvegicus cDNA clone IMAGE:7100624, with apparent retained intron","Q99P87",87.8,{"v":2E-19,"d":"2.00E-19"},"Resistin",".",".",".",".","pfam06954","Resistin","Resistin. This family consists of several mammalian resistin proteins. Resistin is a 12.5-kDa cysteine-rich secreted polypeptide first reported from rodent adipocytes. It belongs to a multigene family termed RELMs or FIZZ proteins. Plasma resistin levels are significantly increased in both genetically susceptible and high-fat-diet-induced obese mice. Immunoneutralization of resistin improves hyperglycemia and insulin resistance in high-fat-diet-induced obese mice, while administration of recombinant resistin impairs glucose tolerance and insulin action in normal mice. It has been demonstrated that increases in circulating resistin levels markedly stimulate glucose production in the presence of fixed physiological insulin levels, whereas insulin suppressed resistin expression. It has been suggested that resistin could be a link between obesity and type 2 diabetes.","GO:0007165|signal transduction;GO:0007568|aging;GO:0009612|response to mechanical stimulus;GO:0010714|positive regulation of collagen metabolic process;GO:0014911|positive regulation of smooth muscle cell migration;GO:0032868|response to insulin;GO:0045444|fat cell differentiation;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0050806|positive regulation of synaptic transmission;GO:2000252|negative regulation of feeding behavior;GO:2000872|positive regulation of progesterone secretion;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005634|nucleus;","GO:0005179|hormone activity;","K13438","RETN; resistin"]
["ENSRNOG00000065528",1,0.064330438,28,1.80773207,0.035586268,-4.812535541,{"v":5.76529e-08,"d":"5.77E-08"},{"v":5.27851e-08,"d":"5.28E-08"},"down","yes","St8sia2","protein_coding","chr1:127762573-127838091:-","gi|16924022|ref|NP_476497.1|",1921,0,"alpha-2,8-sialyltransferase 8B precursor [Rattus norvegicus]","gi|164698488|ref|NM_009181.2|",3969,0,"Mus musculus ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 (St8sia2), mRNA","Q07977",744,0,"Alpha-2,8-sialyltransferase 8B",".",".",".",".","pfam00777","Glyco_transf_29","Glycosyltransferase family 29 (sialyltransferase). Members of this family belong to glycosyltransferase family 29.",".",".",".",".","."]
["ENSRNOG00000064232",77,4.95344374,159,10.26533569,0.482540843,-1.051277034,{"v":5.95898e-08,"d":"5.96E-08"},{"v":5.45148e-08,"d":"5.45E-08"},"down","yes","ENSRNOG00000064232","protein_coding","chr1:182812512-182820806:-","gi|672014318|ref|XP_008772893.1|",1782,0,"PREDICTED: zinc finger protein 239-like [Rattus norvegicus]","gi|672014317|ref|XM_008774671.1|",2869,0,"PREDICTED: Rattus norvegicus zinc finger protein 239-like (LOC103691238), mRNA","Q15937",308,{"v":2E-90,"d":"2.00E-90"},"Zinc finger protein 79",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.",".",".",".",".","."]
["ENSRNOG00000063859",0,0.032165219,27,1.743170211,0.018452139,-5.760068122,{"v":6.24805e-08,"d":"6.25E-08"},{"v":5.70587e-08,"d":"5.71E-08"},"down","yes","ENSRNOG00000063859","protein_coding","chr4:96837125-96837624:+","gi|204787|gb|AAA41396.1|",514,{"v":3e-64,"d":"3.00E-64"},"Immunoglobulin kappa-chain VJ precursor, partial [Rattus norvegicus]","gi|672088081|ref|XM_008773381.1|",281,{"v":6e-144,"d":"6.00E-144"},"PREDICTED: Rattus norvegicus Ig kappa chain V-V region L6-like (LOC103690610), transcript variant X2, mRNA","P01638",177,{"v":3e-56,"d":"3.00E-56"},"Ig kappa chain V-V region L6 (Fragment)",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.",".",".",".",".","."]
["ENSRNOG00000004013",9,0.578973944,48,3.098969263,0.186827908,-2.420218119,{"v":6.3733e-08,"d":"6.37E-08"},{"v":5.81654E-8,"d":"5.82E-08"},"down","yes","Grip1","protein_coding","chr7:54934250-55592273:+","gi|149066844|gb|EDM16577.1|",5197,0,"glutamate receptor interacting protein 1, isoform CRA_b [Rattus norvegicus]","gi|14091753|ref|NM_032069.1|",4226,0,"Rattus norvegicus glutamate receptor interacting protein 1 (Grip1), mRNA","P97879",2001,0,"Glutamate receptor-interacting protein 1",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.","GO:0007399|nervous system development;GO:0008104|protein localization;GO:0015031|protein transport;GO:0016358|dendrite development;GO:0098887|neurotransmitter receptor transport, endosome to postsynaptic membrane;GO:0099003|vesicle-mediated transport in synapse;GO:0140059|dendrite arborization;GO:0150012|positive regulation of neuron projection arborization;","GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0030425|dendrite;GO:0031410|cytoplasmic vesicle;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0045121|membrane raft;GO:0045211|postsynaptic membrane;GO:0055037|recycling endosome;GO:0098794|postsynapse;GO:0098978|glutamatergic synapse;","GO:0005102|signaling receptor binding;GO:0005515|protein binding;GO:0008022|protein C-terminus binding;GO:0030159|receptor signaling complex scaffold activity;GO:0035259|glucocorticoid receptor binding;","K20251","GRIP; glutamate receptor-interacting protein"]
["ENSRNOG00000003705",33,2.12290446,92,5.939691088,0.35740991,-1.484348456,{"v":6.65065e-08,"d":"6.65E-08"},{"v":6.06384e-08,"d":"6.06E-08"},"down","yes","Bmx","protein_coding","chrX:30227251-30289993:+","gi|157824055|ref|NP_001102486.1|",3384,0,"cytoplasmic tyrosine-protein kinase BMX [Rattus norvegicus]","gi|157824054|ref|NM_001109016.1|",2984,0,"Rattus norvegicus BMX non-receptor tyrosine kinase (Bmx), mRNA","P97504",1246,0,"Cytoplasmic tyrosine-protein kinase BMX",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0002250|adaptive immune response;GO:0007165|signal transduction;GO:0035556|intracellular signal transduction;GO:0038083|peptidyl-tyrosine autophosphorylation;GO:0046777|protein autophosphorylation;GO:0050853|B cell receptor signaling pathway;","GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0032587|ruffle membrane;","GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0005524|ATP binding;GO:0046872|metal ion binding;","K08896","BMX, ETK; cytoplasmic tyrosine-protein kinase BMX [EC:2.7.10.2]"]
["ENSRNOG00000014007",6,0.385982629,41,2.647036246,0.145816904,-2.777770123,{"v":6.972e-08,"d":"6.97E-08"},{"v":6.34772e-08,"d":"6.35E-08"},"down","yes","Gfod1","protein_coding","chr17:21399479-21499938:+","gi|281332180|ref|NP_001163805.1|",2093,0,"glucose-fructose oxidoreductase domain-containing protein 1 [Rattus norvegicus]","gi|672081473|ref|XM_006253805.2|",1427,0,"PREDICTED: Rattus norvegicus glucose-fructose oxidoreductase domain containing 1 (Gfod1), transcript variant X1, mRNA","Q3UHD2",808,0,"Glucose-fructose oxidoreductase domain-containing protein 1",".",".",".",".","pfam01408","GFO_IDH_MocA","Oxidoreductase family, NAD-binding Rossmann fold. This family of enzymes utilize NADP or NAD. This family is called the GFO/IDH/MOCA family in swiss-prot.",".",".","GO:0000166|nucleotide binding;GO:0016491|oxidoreductase activity;",".","."]
["ENSRNOG00000039471",53,3.409513224,123,7.941108738,0.429349772,-1.21977467,{"v":7.78639e-08,"d":"7.79E-08"},{"v":7.06553e-08,"d":"7.07E-08"},"down","yes","Pcdhb16l","protein_coding","chr18:29192124-29200539:+","gi|149017304|gb|EDL76355.1|",3667,0,"rCG49511 [Rattus norvegicus]","gi|86440007|gb|AC096374.7|",4925,0,"Rattus norvegicus BAC CH230-17K7 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q9NRJ7",1041,0,"Protocadherin beta-16",".",".",".",".","pfam08266","Cadherin_2","Cadherin-like. This cadherin domain is usually the most N-terminal copy of the domain.","GO:0007155|cell adhesion;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;","GO:0005887|integral component of plasma membrane;","GO:0005509|calcium ion binding;","K16494","PCDHB; protocadherin beta"]
["ENSRNOG00000008592",7,0.450313067,43,2.776159965,0.162207176,-2.624090452,{"v":8.45583e-08,"d":"8.46E-08"},{"v":7.65112E-8,"d":"7.65E-08"},"down","yes","Barx2","protein_coding","chr8:30251132-30319013:-","gi|392341840|ref|XP_003754445.1|",1203,{"v":2e-157,"d":"2.00E-157"},"PREDICTED: homeobox protein BarH-like 2 [Rattus norvegicus]","gi|672022652|ref|XM_003754397.3|",1828,0,"PREDICTED: Rattus norvegicus BARX homeobox 2 (Barx2), mRNA","O08686",448,{"v":1e-151,"d":"1.00E-151"},"Homeobox protein BarH-like 2",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001502|cartilage condensation;GO:0006357|regulation of transcription by RNA polymerase II;GO:0014902|myotube differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0015629|actin cytoskeleton;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003700|DNA-binding transcription factor activity;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09361","BARX; BarH-like homeobox"]
["ENSRNOG00000003929",39,2.508887089,101,6.520747825,0.384754503,-1.377989883,{"v":8.76528E-8,"d":"8.77E-08"},{"v":7.92108e-08,"d":"7.92E-08"},"down","yes","ENSRNOG00000003929","protein_coding","chrX:96771947-96873524:-","gi|564399949|ref|XP_006257284.1|",5858,0,"PREDICTED: protocadherin-19 isoform X1 [Rattus norvegicus]","gi|157426848|ref|NM_001105245.1|",4923,0,"Mus musculus protocadherin 19 (Pcdh19), transcript variant 1, mRNA","Q80TF3",2219,0,"Protocadherin-19",".",".",".",".","pfam00028","Cadherin","Cadherin domain.","GO:0007155|cell adhesion;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007420|brain development;","GO:0005887|integral component of plasma membrane;","GO:0005509|calcium ion binding;","K16499","PCDHD2; protocadherin delta 2"]
["ENSRNOG00000065061",5,0.321652191,38,2.453350667,0.131107304,-2.931180038,{"v":9.61448e-08,"d":"9.61E-08"},{"v":8.67614E-8,"d":"8.68E-08"},"down","yes","ENSRNOG00000065061","lncRNA","chr10:53663938-53666998:-","gi|149066508|gb|EDM16381.1|",194,{"v":7e-16,"d":"7.00E-16"},"rCG63686 [Rattus norvegicus]","gi|672067765|ref|XM_008767789.1|",155,{"v":2E-73,"d":"2.00E-73"},"PREDICTED: Rattus norvegicus Rho guanine nucleotide exchange factor (GEF) 15 (Arhgef15), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam12974","Phosphonate-bd","ABC transporter, phosphonate, periplasmic substrate-binding protein. This is a family of periplasmic proteins which are part of the transport system for alkylphosphonate uptake.",".",".",".",".","."]
["ENSRNOG00000061895",81,5.210765493,163,10.52358312,0.495151265,-1.014058771,{"v":9.94378e-08,"d":"9.94E-08"},{"v":8.96763e-08,"d":"8.97E-08"},"down","yes","Ly49si1","protein_coding","chr4:163586930-163827002:-","gi|672051541|ref|XP_008761656.1|",1443,0,"PREDICTED: T-cell surface glycoprotein YE1/48-like isoform X2 [Rattus norvegicus]","gi|672051196|ref|XM_008763316.1|",934,0,"PREDICTED: Rattus norvegicus immunoreceptor Ly49si1 (Ly49si1), transcript variant X5, mRNA","P20937",326,{"v":7e-108,"d":"7.00E-108"},"T-cell surface glycoprotein YE1/48",".",".",".",".","pfam08391","Ly49","Ly49-like protein, N-terminal region. The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000047546",0,0.032165219,26,1.678608351,0.019161837,-5.705620337,{"v":1.09588E-7,"d":"1.10E-07"},{"v":9.83952E-8,"d":"9.84E-08"},"down","yes","Gas2l2","protein_coding","chr10:68222475-68229881:-","gi|305682553|ref|NP_001099293.2|",3768,0,"GAS2-like protein 2 [Rattus norvegicus]","gi|672089558|ref|XM_008773804.1|",3532,0,"PREDICTED: Rattus norvegicus GAS2-like protein 2 (LOC103694862), mRNA","Q5SSG4",1232,0,"GAS2-like protein 2",".",".",".",".","pfam02187","GAS2","Growth-Arrest-Specific Protein 2 Domain.","GO:0001578|microtubule bundle formation;GO:0007026|negative regulation of microtubule depolymerization;GO:0031110|regulation of microtubule polymerization or depolymerization;GO:0045745|positive regulation of G protein-coupled receptor signaling pathway;GO:0051764|actin crosslink formation;GO:0060296|regulation of cilium beat frequency involved in ciliary motility;GO:1904825|protein localization to microtubule plus-end;","GO:0001725|stress fiber;GO:0005737|cytoplasm;GO:0005874|microtubule;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0035371|microtubule plus-end;GO:0036064|ciliary basal body;","GO:0001965|G-protein alpha-subunit binding;GO:0005515|protein binding;GO:0008017|microtubule binding;GO:0008093|cytoskeletal adaptor activity;GO:0051015|actin filament binding;","K24627","GAS2, GAS2L; growth arrest-specific protein 2"]
["ENSRNOG00000015830",16,1.029287011,61,3.938273439,0.261354887,-1.935917957,{"v":1.13618e-07,"d":"1.14E-07"},{"v":1.01917E-7,"d":"1.02E-07"},"down","yes","Ano9","protein_coding","chr1:196197341-196229900:-","gi|564298594|ref|XP_006223625.1|",3486,0,"PREDICTED: anoctamin-9 isoform X1 [Rattus norvegicus]","gi|672039015|ref|XM_006230589.2|",2924,0,"PREDICTED: Rattus norvegicus anoctamin 9 (Ano9), transcript variant X1, mRNA","P86044",1181,0,"Anoctamin-9",".",".",".",".","pfam04547","Anoctamin","Calcium-activated chloride channel. The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.","GO:0006821|chloride transport;GO:0055085|transmembrane transport;GO:0061589|calcium activated phosphatidylserine scrambling;GO:0061590|calcium activated phosphatidylcholine scrambling;GO:0061591|calcium activated galactosylceramide scrambling;GO:1902476|chloride transmembrane transport;GO:1902939|negative regulation of intracellular calcium activated chloride channel activity;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0005229|intracellular calcium activated chloride channel activity;GO:0005254|chloride channel activity;GO:0017128|phospholipid scramblase activity;","K19503","ANO9, TMEM16J; anoctamin-9"]
["ENSRNOG00000053075",32,2.058574022,89,5.746005509,0.358261756,-1.48091405,{"v":1.1426e-07,"d":"1.14E-07"},{"v":1.02461e-07,"d":"1.02E-07"},"down","yes","B4galnt4","protein_coding","chr1:196171394-196182294:+","gi|157820677|ref|NP_001101032.1|",4582,0,"N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1 [Rattus norvegicus]","gi|157820676|ref|NM_001107562.1|",3546,0,"Rattus norvegicus beta-1,4-N-acetyl-galactosaminyl transferase 4 (B4galnt4), mRNA","Q766D5",1723,0,"N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1",".",".",".",".","pfam05679","CHGN","Chondroitin N-acetylgalactosaminyltransferase.",".","GO:0016021|integral component of membrane;GO:0032580|Golgi cisterna membrane;","GO:0008376|acetylgalactosaminyltransferase activity;GO:0033842|N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity;","K09657","B4GALNT4; beta-1,4-N-acetylgalactosaminyltransferase 4 [EC:2.4.1.244]"]
["ENSRNOG00000058615",13,0.836295696,55,3.550902281,0.235516393,-2.086100615,{"v":1.24226e-07,"d":"1.24E-07"},{"v":1.11153E-7,"d":"1.11E-07"},"down","yes","U6","snRNA","chr1:181153246-181153352:-","gi|686705190|ref|XP_009231420.1|",124,9e-08,"PREDICTED: actin, alpha skeletal muscle-like [Pongo abelii]",".",".",".",".",".",".",".",".",".",".",".",".","pfam06750","DiS_P_DiS","Bacterial Peptidase A24 N-terminal domain. This family is found at the N-terminus of the pre-pilin peptidases (pfam01478). It's function has not been specifically determined; however some of the family have been characterized as bifunctional, and this domain may contain the N-methylation activity (EC:2.1.1.-). It consists of an intracellular region between a pair of transmembrane. This region contains an invariant proline and two almost fully conserved disulphide bridges - hence the name DiS-P-DiS. The cysteines have been shown to be essential to the overall function of the enzyme in, but their role was incorrectly ascribed.",".",".",".",".","."]
["ENSRNOG00000055530",45,2.894869718,109,7.037242702,0.411364201,-1.281511848,{"v":1.46847e-07,"d":"1.47E-07"},{"v":1.30698E-7,"d":"1.31E-07"},"down","yes","Panx2","protein_coding","chr7:120139294-120152361:+","gi|163838639|ref|NP_955441.2|",3146,0,"pannexin-2 [Rattus norvegicus]","gi|163838638|ref|NM_199409.2|",3344,0,"Rattus norvegicus pannexin 2 (Panx2), mRNA","P60571",1216,0,"Pannexin-2",".",".",".",".","pfam00876","Innexin","Innexin. This family includes the drosophila proteins Ogre and shaking-B, and the C. elegans proteins Unc-7 and Unc-9. Members of this family are integral membrane proteins which are involved in the formation of gap junctions. This family has been named the Innexins.","GO:0002931|response to ischemia;GO:0006812|cation transport;GO:0007267|cell-cell signaling;GO:0032732|positive regulation of interleukin-1 production;GO:0055085|transmembrane transport;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005921|gap junction;GO:0016021|integral component of membrane;","GO:0005198|structural molecule activity;GO:0005243|gap junction channel activity;GO:0015267|channel activity;GO:0022829|wide pore channel activity;GO:0044877|protein-containing complex binding;","K20857","PANX2_3; pannexin 2/3"]
["ENSRNOG00000069883",5,0.321652191,37,2.388788807,0.134650744,-2.89270589,{"v":1.70545E-7,"d":"1.71E-07"},{"v":1.51037E-7,"d":"1.51E-07"},"down","yes","ENSRNOG00000069883","lncRNA","chr19:39024185-39027888:-","gi|672031272|ref|XP_008772457.1|",518,{"v":7e-59,"d":"7.00E-59"},"PREDICTED: heterogeneous nuclear ribonucleoprotein C-like 1 isoform X3 [Rattus norvegicus]","gi|255004822|gb|AC111287.5|",1397,0,"Rattus norvegicus CH230-55H2 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam15240","Pro-rich","Proline-rich. This family includes several eukaryotic proline-rich proteins.",".",".",".",".","."]
["ENSRNOG00000002723",62,3.988487167,134,8.651289194,0.461028071,-1.117073499,{"v":1.72109E-7,"d":"1.72E-07"},{"v":1.52398e-07,"d":"1.52E-07"},"down","yes","Sele","protein_coding","chr13:76403304-76412741:+","gi|149058209|gb|EDM09366.1|",2835,0,"selectin, endothelial cell, isoform CRA_b [Rattus norvegicus]","gi|20302052|ref|NM_138879.1|",3273,0,"Rattus norvegicus selectin E (Sele), mRNA","P98105",1096,0,"E-selectin",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0002092|positive regulation of receptor internalization;GO:0002687|positive regulation of leukocyte migration;GO:0006954|inflammatory response;GO:0007155|cell adhesion;GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007159|leukocyte cell-cell adhesion;GO:0007202|activation of phospholipase C activity;GO:0030029|actin filament-based process;GO:0034097|response to cytokine;GO:0050900|leukocyte migration;GO:0050901|leukocyte tethering or rolling;GO:0070555|response to interleukin-1;GO:1903238|positive regulation of leukocyte tethering or rolling;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005887|integral component of plasma membrane;GO:0005901|caveola;GO:0005905|clathrin-coated pit;GO:0009897|external side of plasma membrane;GO:0030863|cortical cytoskeleton;GO:0045121|membrane raft;GO:0048471|perinuclear region of cytoplasm;","GO:0003674|molecular_function;GO:0004888|transmembrane signaling receptor activity;GO:0033691|sialic acid binding;GO:0043274|phospholipase binding;GO:0046872|metal ion binding;GO:0070492|oligosaccharide binding;","K06494","SELE, CD62E; selectin, endothelial cell"]
["ENSRNOG00000012608",9,0.578973944,46,2.969845544,0.19495086,-2.358817574,{"v":1.83803e-07,"d":"1.84E-07"},{"v":1.6235e-07,"d":"1.62E-07"},"down","yes","Tmem212","protein_coding","chr2:110775953-110813273:-","gi|672042017|ref|XP_008759120.1|",1036,{"v":1E-135,"d":"1.00E-135"},"PREDICTED: transmembrane protein 212 isoform X2 [Rattus norvegicus]","gi|256574777|ref|NM_001164438.1|",746,0,"Rattus norvegicus transmembrane protein 212 (Tmem212), transcript variant 1, mRNA","Q8C6V3",346,{"v":4e-115,"d":"4.00E-115"},"Transmembrane protein 212",".",".",".",".","pfam05805","L6_membrane","L6 membrane protein. This family consists of several eukaryotic L6 membrane proteins. L6, IL-TMP, and TM4SF5 are cell surface proteins predicted to have four transmembrane domains. Previous sequence analysis led to their assignment as members of the tetraspanin superfamily it has now been found that that they are not significantly related to genuine tetraspanins, but instead constitute their own L6 family. Several members of this family have been implicated in human cancer.",".","GO:0016021|integral component of membrane;",".","K22196","TMEM212; transmembrane protein 212"]
["ENSRNOG00000047349",9,0.578973944,46,2.969845544,0.19495086,-2.358817574,{"v":1.83803e-07,"d":"1.84E-07"},{"v":1.6235e-07,"d":"1.62E-07"},"down","yes","Ms4a6b","protein_coding","chr1:208291950-208301843:+","gi|293344625|ref|XP_001075462.2|",1117,{"v":4e-151,"d":"4.00E-151"},"PREDICTED: membrane-spanning 4-domains subfamily A member 6B [Rattus norvegicus]","gi|672014687|ref|XM_008774778.1|",915,0,"PREDICTED: Rattus norvegicus membrane-spanning 4-domains, subfamily A, member 6B (Ms4a6b), transcript variant X3, mRNA","Q99N09",323,{"v":8e-109,"d":"8.00E-109"},"Membrane-spanning 4-domains subfamily A member 6B",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.",".",".",".",".","."]
["ENSRNOG00000021313",0,0.032165219,25,1.614046491,0.01992831,-5.649036809,{"v":1.92847e-07,"d":"1.93E-07"},{"v":1.69892E-7,"d":"1.70E-07"},"down","yes","ENSRNOG00000021313","protein_coding","chr4:166543755-166607586:+","gi|203605|gb|AAA40970.1|",761,{"v":7e-99,"d":"7.00E-99"},"contiguous repeat polypeptide [Rattus norvegicus]","gi|13542340|gb|M17703.2|RATCRP02",859,0,"Rat contiguous repeat polypeptide (CRP) mRNA, complete cds","P08568",147,{"v":8E-41,"d":"8.00E-41"},"Submandibular gland secretory Glx-rich protein CA",".",".",".",".","pfam11139","DUF2910","Protein of unknown function (DUF2910). Some members in this bacterial family annotate the proteins as cytochrome C biogenesis proteins however this cannot be confirmed. Currently no function for this family is known.","GO:0001895|retina homeostasis;GO:0031214|biomineral tissue development;","GO:0005576|extracellular region;","GO:0046848|hydroxyapatite binding;",".","."]
["ENSRNOG00000046001",0,0.032165219,25,1.614046491,0.01992831,-5.649036809,{"v":1.92847e-07,"d":"1.93E-07"},{"v":1.69892E-7,"d":"1.70E-07"},"down","yes","AABR07030823.1","protein_coding","chr10:101566304-101570237:-","gi|149054848|gb|EDM06665.1|",1722,0,"forkhead box J1 [Rattus norvegicus]","gi|16758685|ref|NM_053832.1|",2247,0,"Rattus norvegicus forkhead box J1 (Foxj1), mRNA","Q63247",664,0,"Forkhead box protein J1","ECU11g1330",112,{"v":3e-26,"d":"3.00E-26"},"COG5025","pfam00250","Fork_head","Fork head domain.",".",".",".",".","."]
["ENSRNOG00000069584",0,0.032165219,25,1.614046491,0.01992831,-5.649036809,{"v":1.92847e-07,"d":"1.93E-07"},{"v":1.69892E-7,"d":"1.70E-07"},"down","yes","Rnase1l2","protein_coding","chr15:24421859-24423611:+","gi|68341975|ref|NP_001020287.1|",747,{"v":2e-96,"d":"2.00E-96"},"ribonuclease pancreatic gamma-type precursor [Rattus norvegicus]","gi|564385946|ref|XM_006251875.1|",828,0,"PREDICTED: Rattus norvegicus ribonuclease, RNase A family, 1-like 2 (pancreatic) (Rnase1l2), transcript variant X1, mRNA","Q8VD89",292,{"v":6E-98,"d":"6.00E-98"},"Ribonuclease pancreatic gamma-type",".",".",".",".","pfam00074","RnaseA","Pancreatic ribonuclease. Ribonucleases. Members include pancreatic RNAase A and angiogenins. Structure is an alpha+beta fold -- long curved beta sheet and three helices.",".",".",".",".","."]
["ENSRNOG00000012175",6,0.385982629,39,2.517912527,0.153294694,-2.705620337,{"v":2.14181E-7,"d":"2.14E-07"},{"v":1.87932e-07,"d":"1.88E-07"},"down","yes","Nfatc2","protein_coding","chr3:157198872-157328325:-","gi|157821773|ref|NP_001101275.1|",4154,0,"nuclear factor of activated T-cells, cytoplasmic 2 [Rattus norvegicus]","gi|157821772|ref|NM_001107805.1|",2824,0,"Rattus norvegicus nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (Nfatc2), mRNA","Q60591",1571,0,"Nuclear factor of activated T-cells, cytoplasmic 2",".",".",".",".","pfam00554","RHD","Rel homology domain (RHD). Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See pfam01833) that binds to DNA.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001816|cytokine production;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006974|cellular response to DNA damage stimulus;GO:0008150|biological_process;GO:0009410|response to xenobiotic stimulus;GO:0010628|positive regulation of gene expression;GO:0014904|myotube cell development;GO:0016477|cell migration;GO:0030890|positive regulation of B cell proliferation;GO:0033173|calcineurin-NFAT signaling cascade;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050853|B cell receptor signaling pathway;GO:1901741|positive regulation of myoblast fusion;GO:1905064|negative regulation of vascular smooth muscle cell differentiation;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:1990904|ribonucleoprotein complex;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003682|chromatin binding;GO:0003700|DNA-binding transcription factor activity;GO:0008134|transcription factor binding;GO:0019902|phosphatase binding;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K17332","NFATC2, NFAT1, NFATP; nuclear factor of activated T-cells, cytoplasmic 2"]
["ENSRNOG00000054416",4,0.257321753,34,2.195103228,0.117225354,-3.092643461,{"v":2.26241e-07,"d":"2.26E-07"},{"v":1.98119E-7,"d":"1.98E-07"},"down","yes","Fam124b","protein_coding","chr9:81515399-81533341:-","gi|392342438|ref|XP_002727294.2|",2286,0,"PREDICTED: protein FAM124B [Rattus norvegicus]","gi|672024190|ref|XM_002727248.4|",1399,0,"PREDICTED: Rattus norvegicus family with sequence similarity 124B (Fam124b), mRNA","Q8BLQ0",801,0,"Protein FAM124B",".",".",".",".","pfam15067","FAM124","FAM124 family. The exact function of this protein family remains unknown. This family of proteins is found in eukaryotes. Proteins in this family are approximately 480 amino acids in length. There is a conserved LFL sequence motif.",".","GO:0005654|nucleoplasm;GO:0005739|mitochondrion;",".",".","."]
["ENSRNOG00000065204",4,0.257321753,34,2.195103228,0.117225354,-3.092643461,{"v":2.26241e-07,"d":"2.26E-07"},{"v":1.98119E-7,"d":"1.98E-07"},"down","yes","Fam166b","protein_coding","chr5:57675462-57678611:-","gi|532038518|ref|XP_005362126.1|",1161,{"v":9E-157,"d":"9.00E-157"},"PREDICTED: protein FAM166B isoform X1 [Microtus ochrogaster]","gi|755506548|ref|XM_006538012.2|",747,0,"PREDICTED: Mus musculus family with sequence similarity 166, member B (Fam166b), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam10629","DUF2475","Protein of unknown function (DUF2475). This family of proteins has no known function.",".",".",".",".","."]
["ENSRNOG00000042623",7,0.450313067,41,2.647036246,0.170119721,-2.555377702,{"v":2.53503e-07,"d":"2.54E-07"},{"v":2.21314e-07,"d":"2.21E-07"},"down","yes","Sh2d4b","protein_coding","chr16:16677889-16769087:-","gi|281332212|ref|NP_001163820.1|",1830,0,"SH2 domain-containing protein 4B [Rattus norvegicus]","gi|281332211|ref|NM_001170349.1|",1296,0,"Rattus norvegicus SH2 domain containing 4B (Sh2d4b), mRNA",".",".",".",".",".",".",".",".","pfam00017","SH2","SH2 domain.",".","GO:0005737|cytoplasm;",".",".","."]
["ENSRNOG00000045816",17,1.093617449,61,3.938273439,0.277689568,-1.848455116,{"v":2.72983e-07,"d":"2.73E-07"},{"v":2.37739e-07,"d":"2.38E-07"},"down","yes","Gria1","protein_coding","chr10:41210713-41527283:+","gi|34328128|ref|NP_032191.2|",4637,0,"glutamate receptor 1 isoform 2 precursor [Mus musculus]","gi|29789268|ref|NM_031608.1|",2965,0,"Rattus norvegicus glutamate ionotropic receptor AMPA type subunit 1 (Gria1), mRNA","P19490",1791,0,"Glutamate receptor 1",".",".",".",".","pfam00060","Lig_chan","Ligand-gated ion channel. This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.","GO:0001919|regulation of receptor recycling;GO:0007268|chemical synaptic transmission;GO:0007616|long-term memory;GO:0009410|response to xenobiotic stimulus;GO:0009636|response to toxic substance;GO:0010226|response to lithium ion;GO:0014070|response to organic cyclic compound;GO:0019228|neuronal action potential;GO:0021510|spinal cord development;GO:0031623|receptor internalization;GO:0032355|response to estradiol;GO:0034220|ion transmembrane transport;GO:0035235|ionotropic glutamate receptor signaling pathway;GO:0035249|synaptic transmission, glutamatergic;GO:0042220|response to cocaine;GO:0043434|response to peptide hormone;GO:0045838|positive regulation of membrane potential;GO:0046685|response to arsenic-containing substance;GO:0048167|regulation of synaptic plasticity;GO:0050804|modulation of chemical synaptic transmission;GO:0050806|positive regulation of synaptic transmission;GO:0051602|response to electrical stimulus;GO:0060078|regulation of postsynaptic membrane potential;GO:0060292|long-term synaptic depression;GO:0060992|response to fungicide;GO:0071230|cellular response to amino acid stimulus;GO:0071242|cellular response to ammonium ion;GO:0071359|cellular response to dsRNA;GO:0071363|cellular response to growth factor stimulus;GO:0071375|cellular response to peptide hormone stimulus;GO:0071407|cellular response to organic cyclic compound;GO:0071418|cellular response to amine stimulus;GO:0099566|regulation of postsynaptic cytosolic calcium ion concentration;","GO:0005769|early endosome;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0008021|synaptic vesicle;GO:0008328|ionotropic glutamate receptor complex;GO:0009986|cell surface;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0030672|synaptic vesicle membrane;GO:0031594|neuromuscular junction;GO:0031901|early endosome membrane;GO:0032279|asymmetric synapse;GO:0032281|AMPA glutamate receptor complex;GO:0032590|dendrite membrane;GO:0032591|dendritic spine membrane;GO:0032991|protein-containing complex;GO:0036477|somatodendritic compartment;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043197|dendritic spine;GO:0043198|dendritic shaft;GO:0044297|cell body;GO:0044308|axonal spine;GO:0044309|neuron spine;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0055037|recycling endosome;GO:0055038|recycling endosome membrane;GO:0060076|excitatory synapse;GO:0097060|synaptic membrane;GO:0098794|postsynapse;GO:0098839|postsynaptic density membrane;GO:0098978|glutamatergic synapse;GO:0099055|integral component of postsynaptic membrane;GO:0099056|integral component of presynaptic membrane;GO:0099061|integral component of postsynaptic density membrane;GO:0099544|perisynaptic space;","GO:0001540|amyloid-beta binding;GO:0001965|G-protein alpha-subunit binding;GO:0004970|ionotropic glutamate receptor activity;GO:0004971|AMPA glutamate receptor activity;GO:0005515|protein binding;GO:0008022|protein C-terminus binding;GO:0008179|adenylate cyclase binding;GO:0015276|ligand-gated ion channel activity;GO:0019865|immunoglobulin binding;GO:0019901|protein kinase binding;GO:0019904|protein domain specific binding;GO:0030165|PDZ domain binding;GO:0031267|small GTPase binding;GO:0031489|myosin V binding;GO:0031681|G-protein beta-subunit binding;GO:0031698|beta-2 adrenergic receptor binding;GO:0035254|glutamate receptor binding;GO:0038023|signaling receptor activity;GO:0042802|identical protein binding;GO:0051018|protein kinase A binding;GO:0097110|scaffold protein binding;GO:0099583|neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration;GO:1904315|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K05197","GRIA1; glutamate receptor 1"]
["ENSRNOG00000003950",16,1.029287011,59,3.80914972,0.270214375,-1.887823669,{"v":2.91597e-07,"d":"2.92E-07"},{"v":2.53331e-07,"d":"2.53E-07"},"down","yes","Lvrn","protein_coding","chr18:39607722-39675165:+","gi|109507289|ref|XP_001054995.1|",5017,0,"PREDICTED: aminopeptidase Q isoform X1 [Rattus norvegicus]","gi|672030658|ref|XM_001054995.3|",3270,0,"PREDICTED: Rattus norvegicus laeverin (Lvrn), transcript variant X1, mRNA","Q6Q4G3",1336,0,"Aminopeptidase Q","YHR047c",303,{"v":8e-87,"d":"8.00E-87"},"COG0308","pfam01433","Peptidase_M1","Peptidase family M1. Members of this family are aminopeptidases. The members differ widely in specificity, hydrolysing acidic, basic or neutral N-terminal residues. This family includes leukotriene-A4 hydrolase, this enzyme also has an aminopeptidase activity.","GO:0006508|proteolysis;GO:0007165|signal transduction;GO:0008217|regulation of blood pressure;GO:0043171|peptide catabolic process;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;","GO:0008270|zinc ion binding;GO:0042277|peptide binding;GO:0070006|metalloaminopeptidase activity;","K13724","AQPEP; aminopeptidase Q [EC:3.4.11.-]"]
["ENSRNOG00000033733",21,1.350939202,68,4.390206457,0.307716554,-1.700326038,{"v":3.00689E-7,"d":"3.01E-07"},{"v":2.60992e-07,"d":"2.61E-07"},"down","yes","Ccdc81","protein_coding","chr1:143739474-143790926:-","gi|62078773|ref|NP_001014043.1|",3291,0,"coiled-coil domain-containing protein 81 [Rattus norvegicus]","gi|62078772|ref|NM_001014021.1|",2352,0,"Rattus norvegicus coiled-coil domain containing 81 (Ccdc81), mRNA","Q5XIN9",1247,0,"Coiled-coil domain-containing protein 81",".",".",".",".","pfam14908","DUF4496","Domain of unknown function (DUF4496). This domain family is found in eukaryotes, and is typically between 134 and 154 amino acids in length. Proteins in this family vary in length between 264 and 772 amino acid residues.",".",".",".",".","."]
["ENSRNOG00000049277",49,3.152191471,113,7.295490141,0.432073981,-1.210649738,{"v":3.07854E-7,"d":"3.08E-07"},{"v":2.66684e-07,"d":"2.67E-07"},"down","yes","Syne4","protein_coding","chr1:85569545-85573760:+","gi|392344104|ref|XP_003748870.1|",1560,0,"PREDICTED: nesprin-4 isoform X2 [Rattus norvegicus]","gi|564327446|ref|XM_003748822.2|",1287,0,"PREDICTED: Rattus norvegicus nesprin-4-like (LOC100911963), transcript variant X2, mRNA","Q8CII8",524,0,"Nesprin-4",".",".",".",".","pfam10541","KASH","Nuclear envelope localisation domain. The KASH (for Klarsicht/ANC-1/Syne-1 homology) or KLS domain is a highly hydrophobic nuclear envelope localisation domain of approximately 60 amino acids comprising a 20-amino-acid transmembrane region and a 30-35-residue C-terminal region that lies between the inner and the outer nuclear membranes. During meiotic prophase, telomeres cluster to form a bouquet arrangement of chromosomes. SUN and KASH domain proteins form complexes that span both membranes of the nuclear envelope. The KASH domain links the dynein motor complex of the microtubules, through the outer nuclear membrane to the Sad1 domain in the inner nuclear membrane which then interacts with the bouquet proteins Bqt1 and Bqt2 that are complexed with Bqt4, Rap1 and Taz1 and attached to the telomere. SUN domain-containing proteins are essential for recruiting KASH domain proteins at the outer nuclear membrane, and KASH domains provide a generic NE tethering device for functionally distinct proteins whose cytoplasmic domains mediate nuclear positioning, maintain physical connections with other cellular organelles, and possibly even influence chromosome dynamics.","GO:0045198|establishment of epithelial cell apical/basal polarity;","GO:0016021|integral component of membrane;GO:0031309|integral component of nuclear outer membrane;GO:0034993|meiotic nuclear membrane microtubule tethering complex;",".","K23401","SYNE4; nesprin-4"]
["ENSRNOG00000035529",0,0.032165219,24,1.549484632,0.020758656,-5.59014312,{"v":3.4052e-07,"d":"3.41E-07"},{"v":2.93734e-07,"d":"2.94E-07"},"down","yes","Mir135a","miRNA","chr7:26611990-26612089:-",".",".",".",".","gi|262205960|ref|NR_029812.1|",100,{"v":5e-44,"d":"5.00E-44"},"Mus musculus microRNA 135a-2 (Mir135a-2), microRNA",".",".",".",".",".",".",".",".","pfam00057","Ldl_recept_a","Low-density lipoprotein receptor domain class A.","GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0046660|female sex differentiation;GO:0060070|canonical Wnt signaling pathway;GO:1990830|cellular response to leukemia inhibitory factor;",".",".","K17144","MIR135; microRNA 135"]
["ENSRNOG00000063586",0,0.032165219,24,1.549484632,0.020758656,-5.59014312,{"v":3.4052e-07,"d":"3.41E-07"},{"v":2.93734e-07,"d":"2.94E-07"},"down","yes","ENSRNOG00000063586","protein_coding","chr15:42976496-42991363:-","gi|672078559|ref|XP_008769042.1|",773,{"v":1e-94,"d":"1.00E-94"},"PREDICTED: disintegrin and metalloproteinase domain-containing protein 28 isoform X1 [Rattus norvegicus]","gi|672078558|ref|XM_008770820.1|",457,0,"PREDICTED: Rattus norvegicus ADAM metallopeptidase domain 28 (Adam28), transcript variant X1, mRNA","Q9JLN6",293,{"v":4E-92,"d":"4.00E-92"},"Disintegrin and metalloproteinase domain-containing protein 28",".",".",".",".","pfam01562","Pep_M12B_propep","Reprolysin family propeptide. This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the \"cysteine switch\" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.",".",".",".",".","."]
["ENSRNOG00000066437",0,0.032165219,24,1.549484632,0.020758656,-5.59014312,{"v":3.4052e-07,"d":"3.41E-07"},{"v":2.93734e-07,"d":"2.94E-07"},"down","yes","Ntm","protein_coding","chr8:27377773-28366595:-","gi|149027867|gb|EDL83327.1|",1698,0,"rCG22798 [Rattus norvegicus]","gi|8394195|ref|NM_017354.1|",2024,0,"Rattus norvegicus neurotrimin (Ntm), mRNA","Q99PJ0",657,0,"Neurotrimin",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.",".",".",".",".","."]
["ENSRNOG00000063218",1,0.064330438,25,1.614046491,0.03985662,-4.649036809,{"v":3.48424E-7,"d":"3.48E-07"},{"v":3.00371e-07,"d":"3.00E-07"},"down","yes","ENSRNOG00000063218","lncRNA","chr11:35406341-35407614:+","gi|672051768|ref|XP_008761704.1|",265,{"v":1e-32,"d":"1.00E-32"},"PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC102551205 [Rattus norvegicus]","gi|34368617|gb|AC095558.10|",1093,0,"Rattus norvegicus 18 BAC CH230-8D7 (Children's Hospital Oakland Research Institute) complete sequence","P0DOH0",80.5,{"v":3e-30,"d":"3.00E-30"},"Glyco-Gag protein",".",".",".",".","pfam01140","Gag_MA","Matrix protein (MA), p15. The matrix protein, p15, is encoded by the gag gene. MA is involved in pathogenicity.",".",".",".",".","."]
["ENSRNOG00000010357",6,0.385982629,38,2.453350667,0.157328764,-2.668145632,{"v":3.74182e-07,"d":"3.74E-07"},{"v":3.21944e-07,"d":"3.22E-07"},"down","yes","Lhx9","protein_coding","chr13:50389738-50410806:-","gi|532089497|ref|XP_005330445.1|",1844,0,"PREDICTED: LIM/homeobox protein Lhx9 isoform X2 [Ictidomys tridecemlineatus]","gi|672074046|ref|XM_006249916.2|",2621,0,"PREDICTED: Rattus norvegicus LIM homeobox 9 (Lhx9), transcript variant X3, mRNA","Q80W90",712,0,"LIM/homeobox protein Lhx9","ECU03g1170",56.6,6e-08,"COG5576","pfam00046","Homeobox","Homeobox domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0008283|cell proliferation;GO:0008584|male gonad development;GO:0008585|female gonad development;GO:0030182|neuron differentiation;GO:0035262|gonad morphogenesis;GO:0045892|negative regulation of transcription, DNA-templated;GO:0097380|dorsal spinal cord interneuron anterior axon guidance;","GO:0005634|nucleus;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0046872|metal ion binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09373","LHX2_9; LIM homeobox protein 2/9"]
["ENSRNOG00000009291",18,1.157947887,62,4.002835299,0.289281922,-1.789451928,{"v":3.99297e-07,"d":"3.99E-07"},{"v":3.42882e-07,"d":"3.43E-07"},"down","yes","Dnase1l3","protein_coding","chr15:16922335-16948317:+","gi|16758784|ref|NP_446359.1|",1343,{"v":2E-180,"d":"2.00E-180"},"deoxyribonuclease gamma precursor [Rattus norvegicus]","gi|56789879|gb|BC088122.1|",1017,0,"Rattus norvegicus deoxyribonuclease 1-like 3, mRNA (cDNA clone MGC:108624 IMAGE:7325326), complete cds","O89107",521,0,"Deoxyribonuclease gamma",".",".",".",".","pfam03372","Exo_endo_phos","Endonuclease/Exonuclease/phosphatase family. This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins EC:4.2.99.18, DNase I proteins EC:3.1.21.1, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56, Sphingomyelinase EC:3.1.4.12 and Nocturnin.","GO:0000737|DNA catabolic process, endonucleolytic;GO:0002283|neutrophil activation involved in immune response;GO:0002673|regulation of acute inflammatory response;GO:0006308|DNA catabolic process;GO:0006309|apoptotic DNA fragmentation;GO:0010623|programmed cell death involved in cell development;GO:0070948|regulation of neutrophil mediated cytotoxicity;","GO:0005576|extracellular region;GO:0005634|nucleus;GO:0005783|endoplasmic reticulum;","GO:0003677|DNA binding;GO:0004519|endonuclease activity;GO:0004520|endodeoxyribonuclease activity;GO:0004530|deoxyribonuclease I activity;","K11995","DNASE1L; deoxyribonuclease-1-like protein [EC:3.1.21.-]"]
["ENSRNOG00000042522",4,0.257321753,33,2.130541369,0.120777637,-3.049574739,{"v":4.05552e-07,"d":"4.06E-07"},{"v":3.47887E-7,"d":"3.48E-07"},"down","yes","Pheta2","protein_coding","chr7:113857249-113861871:+","gi|194473640|ref|NP_001123983.1|",1188,{"v":2e-153,"d":"2.00E-153"},"sesquipedalian-2 [Rattus norvegicus]","gi|194473639|ref|NM_001130511.1|",2670,0,"Rattus norvegicus family with sequence similarity 109, member B (Fam109b), mRNA","Q14B98",432,{"v":2e-143,"d":"2.00E-143"},"Sesquipedalian-2",".",".",".",".","pfam00169","PH","PH domain. PH stands for pleckstrin homology.","GO:0001881|receptor recycling;GO:0007032|endosome organization;GO:0042147|retrograde transport, endosome to Golgi;","GO:0005769|early endosome;GO:0005802|trans-Golgi network;GO:0005829|cytosol;GO:0030136|clathrin-coated vesicle;GO:0055037|recycling endosome;","GO:0042803|protein homodimerization activity;","K23791","PHETA; sesquipedalian"]
["ENSRNOG00000011133",36,2.315895775,92,5.939691088,0.389901721,-1.358817574,{"v":4.36356e-07,"d":"4.36E-07"},{"v":3.7375e-07,"d":"3.74E-07"},"down","yes","Trpc4","protein_coding","chr2:138308084-138476768:+","gi|32189352|ref|NP_536321.1|",4889,0,"short transient receptor potential channel 4 isoform alpha [Rattus norvegicus]","gi|672042409|ref|XM_006232356.2|",3470,0,"PREDICTED: Rattus norvegicus transient receptor potential cation channel, subfamily C, member 4 (Trpc4), transcript variant X1, mRNA","O35119",1881,0,"Short transient receptor potential channel 4",".",".",".",".","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0006816|calcium ion transport;GO:0006828|manganese ion transport;GO:0014051|gamma-aminobutyric acid secretion;GO:0048709|oligodendrocyte differentiation;GO:0051480|regulation of cytosolic calcium ion concentration;GO:0051924|regulation of calcium ion transport;GO:0070509|calcium ion import;GO:0070588|calcium ion transmembrane transport;GO:0099605|regulation of action potential firing rate;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005901|caveola;GO:0005911|cell-cell junction;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0030863|cortical cytoskeleton;GO:0032991|protein-containing complex;GO:0034703|cation channel complex;GO:0034704|calcium channel complex;GO:0045121|membrane raft;","GO:0005262|calcium channel activity;GO:0008013|beta-catenin binding;GO:0015279|store-operated calcium channel activity;GO:0045296|cadherin binding;GO:0070679|inositol 1,4,5 trisphosphate binding;","K04967","TRPC4; transient receptor potential cation channel subfamily C member 4"]
["ENSRNOG00000004928",7,0.450313067,40,2.582474386,0.174372714,-2.519753792,{"v":4.37332e-07,"d":"4.37E-07"},{"v":3.74474E-7,"d":"3.74E-07"},"down","yes","Sntg2","protein_coding","chr6:46801377-47003372:-","gi|564355593|ref|XP_006240029.1|",2738,0,"PREDICTED: gamma-2-syntrophin isoform X1 [Rattus norvegicus]","gi|568977790|ref|XM_006515109.1|",1878,0,"PREDICTED: Mus musculus syntrophin, gamma 2 (Sntg2), transcript variant X2, mRNA","Q925E0",1018,0,"Gamma-2-syntrophin",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.",".","GO:0005622|intracellular;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0016010|dystrophin-associated glycoprotein complex;","GO:0005198|structural molecule activity;GO:0030165|PDZ domain binding;GO:0097109|neuroligin family protein binding;","K24065","SNTG; gamma-syntrophin"]
["ENSRNOG00000053034",8,0.514643505,42,2.711598106,0.18979343,-2.397498042,{"v":4.87933e-07,"d":"4.88E-07"},{"v":4.1649e-07,"d":"4.16E-07"},"down","yes","AABR07071198.1","protein_coding","chr8:97049597-97099987:-","gi|568896295|ref|XP_006544486.1|",1667,0,"PREDICTED: NACHT, LRR and PYD domains-containing protein 5 isoform X2 [Mus musculus]","gi|755531131|ref|XM_006511608.2|",881,0,"PREDICTED: Mus musculus predicted gene 28729 (Gm28729), transcript variant X4, mRNA",".",".",".",".",".",".",".",".","pfam15242","FAM53","Family of FAM53. The FAM53 protein family refers to a family of proteins, which bind to a transcriptional regulator that modulates cell proliferation. It is known to be highly important in neural tube development. It is found in eukaryotes and is typically between 303 and 413 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000056087",24,1.543930516,72,4.648453895,0.332138503,-1.59014312,{"v":5.03509e-07,"d":"5.04E-07"},{"v":4.29401e-07,"d":"4.29E-07"},"down","yes","Erich2","protein_coding","chr3:55310993-55347184:+","gi|66730305|ref|NP_001019482.1|",1643,0,"glutamate-rich protein 2 [Rattus norvegicus]","gi|66730304|ref|NM_001024311.1|",1653,0,"Rattus norvegicus glutamate-rich 2 (Erich2), mRNA",".",".",".",".",".",".",".",".","pfam15402","Spc7_N","N-terminus of kinetochore NMS complex subunit Spc7.",".",".",".",".","."]
["ENSRNOG00000027295",20,1.286608764,65,4.196520878,0.306589387,-1.705620337,{"v":5.17468e-07,"d":"5.17E-07"},{"v":4.4091E-7,"d":"4.41E-07"},"down","yes","Aph1b","protein_coding","chr8:67429198-67450243:-","gi|114053317|ref|NP_001040555.1|",1133,{"v":2e-151,"d":"2.00E-151"},"gamma-secretase subunit APH-1B [Rattus norvegicus]","gi|672062505|ref|XM_008766401.1|",1279,0,"PREDICTED: Rattus norvegicus gamma-secretase subunit APH-1B-like (LOC100911293), mRNA","Q8C7N7",421,{"v":3e-145,"d":"3.00E-145"},"Gamma-secretase subunit APH-1B",".",".",".",".","pfam06105","Aph-1","Aph-1 protein. This family consists of several eukaryotic Aph-1 proteins.Gamma-secretase catalyses the intramembrane proteolysis of Notch, beta-amyloid precursor protein, and other substrates as part of a new signaling paradigm and as a key step in the pathogenesis of Alzheimer's disease. It is thought that the presenilin heterodimer comprises the catalytic site and that a highly glycosylated form of nicastrin associates with it. Aph-1 and Pen-2, two membrane proteins genetically linked to gamma-secretase, associate directly with presenilin and nicastrin in the active protease complex. Co-expression of all four proteins leads to marked increases in presenilin heterodimers, full glycosylation of nicastrin, and enhanced gamma-secretase activity.","GO:0001963|synaptic transmission, dopaminergic;GO:0006509|membrane protein ectodomain proteolysis;GO:0007219|Notch signaling pathway;GO:0007220|Notch receptor processing;GO:0007614|short-term memory;GO:0007626|locomotory behavior;GO:0010950|positive regulation of endopeptidase activity;GO:0016485|protein processing;GO:0034205|amyloid-beta formation;GO:0035249|synaptic transmission, glutamatergic;GO:0042987|amyloid precursor protein catabolic process;GO:0060134|prepulse inhibition;","GO:0005575|cellular_component;GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;GO:0030133|transport vesicle;GO:0045202|synapse;GO:0070765|gamma-secretase complex;","GO:0003674|molecular_function;GO:0030674|protein binding, bridging;GO:0061133|endopeptidase activator activity;","K06172","APH1; gamma-secretase subunit APH-1"]
["ENSRNOG00000019627",14,0.900626135,54,3.486340421,0.258329947,-1.952713199,{"v":5.20571e-07,"d":"5.21E-07"},{"v":4.43356e-07,"d":"4.43E-07"},"down","yes","Mybpc2","protein_coding","chr1:94994104-95017584:-","gi|625263949|ref|XP_007623417.1|",5170,0,"PREDICTED: myosin-binding protein C, fast-type isoform X3 [Cricetulus griseus]","gi|672036327|ref|XM_006229002.2|",1666,0,"PREDICTED: Rattus norvegicus myosin binding protein C, fast-type (Mybpc2), transcript variant X1, mRNA","Q5XKE0",1968,0,"Myosin-binding protein C, fast-type",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0006936|muscle contraction;",".",".","K12558","MYBPC2; myosin-binding protein C, fast-type"]
["ENSRNOG00000063857",9,0.578973944,44,2.840721825,0.203812263,-2.294687237,{"v":5.24395e-07,"d":"5.24E-07"},{"v":4.46346e-07,"d":"4.46E-07"},"down","yes","ENSRNOG00000063857","pseudogene","chr4:157059499-157061073:-","gi|149049498|gb|EDM01952.1|",2367,0,"rCG29725, isoform CRA_b [Rattus norvegicus]","gi|672051161|ref|XR_592287.1|",502,0,"PREDICTED: Rattus norvegicus similar to complement component 1, s subcomponent (RGD1561715), transcript variant X2, misc_RNA","Q6P6T1",915,0,"Complement C1s subcomponent","VC1649",71.6,{"v":2E-12,"d":"2.00E-12"},"COG5640","pfam00089","Trypsin","Trypsin.",".",".",".",".","."]
["ENSRNOG00000008217",5,0.321652191,35,2.259665088,0.142345073,-2.812535541,{"v":5.33606e-07,"d":"5.34E-07"},{"v":4.53983e-07,"d":"4.54E-07"},"down","yes","Madcam1","protein_coding","chr7:10036301-10039703:-","gi|9506871|ref|NP_062190.1|",1710,0,"mucosal addressin cell adhesion molecule 1 precursor [Rattus norvegicus]","gi|9506870|ref|NM_019317.1|",1279,0,"Rattus norvegicus mucosal vascular addressin cell adhesion molecule 1 (Madcam1), mRNA","O70540",663,0,"Mucosal addressin cell adhesion molecule 1",".",".",".",".","pfam09085","Adhes-Ig_like","Adhesion molecule, immunoglobulin-like. Members of this family are found in a set of mucosal cellular adhesion proteins and adopt an immunoglobulin-like beta-sandwich structure, with seven strands arranged in two beta-sheets in a Greek-key topology. They are essential for recruitment of lymphocytes to specific tissues.","GO:0002687|positive regulation of leukocyte migration;GO:0007155|cell adhesion;GO:0007160|cell-matrix adhesion;GO:0007229|integrin-mediated signaling pathway;GO:0007568|aging;GO:0030216|keratinocyte differentiation;GO:0034113|heterotypic cell-cell adhesion;GO:0043113|receptor clustering;GO:0050900|leukocyte migration;GO:0050901|leukocyte tethering or rolling;GO:2000403|positive regulation of lymphocyte migration;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0098640|integrin binding involved in cell-matrix adhesion;","K06779","MADCAM1; mucosal vascular addressin cell adhesion molecule 1"]
["ENSRNOG00000007012",29,1.865582707,80,5.164948772,0.361200622,-1.469127719,{"v":5.81122e-07,"d":"5.81E-07"},{"v":4.93013e-07,"d":"4.93E-07"},"down","yes","Ly75","protein_coding","chr3:44765122-44852374:-","gi|564301698|ref|XP_006224510.1|",9264,0,"PREDICTED: lymphocyte antigen 75 [Rattus norvegicus]","gi|672045718|ref|XM_006234242.2|",6498,0,"PREDICTED: Rattus norvegicus lymphocyte antigen 75 (Ly75), mRNA","Q60767",3208,0,"Lymphocyte antigen 75",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0006897|endocytosis;","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0030246|carbohydrate binding;GO:0038023|signaling receptor activity;","K06559","LY75, CD205; lymphocyte antigen 75"]
["ENSRNOG00000025793",29,1.865582707,80,5.164948772,0.361200622,-1.469127719,{"v":5.81122e-07,"d":"5.81E-07"},{"v":4.93013e-07,"d":"4.93E-07"},"down","yes","Usp31","protein_coding","chr1:176215889-176278355:-","gi|226443061|ref|NP_001028345.1|",5120,0,"ubiquitin carboxyl-terminal hydrolase 31 [Mus musculus]","gi|157817028|ref|NM_001107548.1|",5018,0,"Rattus norvegicus ubiquitin specific peptidase 31 (Usp31), mRNA","Q70CQ4",1872,0,"Ubiquitin carboxyl-terminal hydrolase 31","SPCC16A11.12c",167,{"v":6e-41,"d":"6.00E-41"},"COG5560","pfam00443","UCH","Ubiquitin carboxyl-terminal hydrolase.","GO:0006511|ubiquitin-dependent protein catabolic process;GO:0016579|protein deubiquitination;","GO:0005634|nucleus;","GO:0004843|thiol-dependent ubiquitin-specific protease activity;","K11852","USP31; ubiquitin carboxyl-terminal hydrolase 31 [EC:3.4.19.12]"]
["ENSRNOG00000024028",0,0.032165219,23,1.484922772,0.021661207,-5.528742575,{"v":6.03393e-07,"d":"6.03E-07"},{"v":5.10391e-07,"d":"5.10E-07"},"down","yes","Sprr1a","protein_coding","chr2:178055096-178057063:-","gi|402747125|ref|NP_068636.1|",361,{"v":7E-39,"d":"7.00E-39"},"cornifin-A [Rattus norvegicus]","gi|402747124|ref|NM_021864.1|",812,0,"Rattus norvegicus small proline-rich protein 1A (Sprr1a), mRNA","Q63532",137,{"v":4e-38,"d":"4.00E-38"},"Cornifin-A",".",".",".",".","pfam02389","Cornifin","Cornifin (SPRR) family. SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteristic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid.","GO:0018149|peptide cross-linking;GO:0030216|keratinocyte differentiation;GO:0031424|keratinization;","GO:0001533|cornified envelope;GO:0005737|cytoplasm;GO:0071944|cell periphery;","GO:0030280|structural constituent of epidermis;",".","."]
["ENSRNOG00000024310",0,0.032165219,23,1.484922772,0.021661207,-5.528742575,{"v":6.03393e-07,"d":"6.03E-07"},{"v":5.10391e-07,"d":"5.10E-07"},"down","yes","Kcnf1","protein_coding","chr6:39962307-39964979:-","gi|281182676|ref|NP_001162575.1|",2623,0,"potassium voltage-gated channel subfamily F member 1 [Rattus norvegicus]","gi|281182675|ref|NM_001169104.1|",2673,0,"Rattus norvegicus potassium voltage-gated channel modifier subfamily F member 1 (Kcnf1), mRNA","Q7TSH7",986,0,"Potassium voltage-gated channel subfamily F member 1","PA1496",117,{"v":7e-28,"d":"7.00E-28"},"COG1226","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0034765|regulation of ion transmembrane transport;GO:0051260|protein homooligomerization;GO:0071805|potassium ion transmembrane transport;GO:1905515|non-motile cilium assembly;","GO:0008076|voltage-gated potassium channel complex;GO:0016021|integral component of membrane;GO:0097546|ciliary base;","GO:0005249|voltage-gated potassium channel activity;","K04899","KCNF1, KV5.1; potassium voltage-gated channel subfamily F member 1"]
["ENSRNOG00000057499",0,0.032165219,23,1.484922772,0.021661207,-5.528742575,{"v":6.03393e-07,"d":"6.03E-07"},{"v":5.10391e-07,"d":"5.10E-07"},"down","yes","AABR07068587.1","pseudogene","chr9:102319963-102320325:-","gi|26341650|dbj|BAC34487.1|",434,{"v":1E-52,"d":"1.00E-52"},"unnamed protein product [Mus musculus]","gi|672066109|ref|XM_006245593.2|",306,{"v":7e-158,"d":"7.00E-158"},"PREDICTED: Rattus norvegicus ephrin A5 (Efna5), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam10719","ComFB","Late competence development protein ComFB. This family is conserved in bacteria. Some members, with three conserved cysteines, are annotated as late competence development protein ComFB.",".",".",".",".","."]
["ENSRNOG00000068182",0,0.032165219,23,1.484922772,0.021661207,-5.528742575,{"v":6.03393e-07,"d":"6.03E-07"},{"v":5.10391e-07,"d":"5.10E-07"},"down","yes","ENSRNOG00000068182","protein_coding","chr14:74037179-74039851:-","gi|674090593|ref|XP_008853349.1|",970,0,"PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103751621, partial [Nannospalax galili]","gi|40841709|gb|AC130969.4|",2453,0,"Rattus norvegicus 2 BAC CH230-105B13 (Children's Hospital Oakland Research Institute) complete sequence","P03336",377,{"v":2E-118,"d":"2.00E-118"},"Gag polyprotein",".",".",".",".","pfam02093","Gag_p30","Gag P30 core shell protein. According to Swiss-Prot annotation this protein is the viral core shell protein. P30 is essential for viral assembly.",".",".",".",".","."]
["ENSRNOG00000063310",1,0.064330438,24,1.549484632,0.041517313,-4.59014312,{"v":6.3733E-7,"d":"6.37E-07"},{"v":5.3838e-07,"d":"5.38E-07"},"down","yes","Pdia2","protein_coding","chr10:15215824-15220931:-","gi|164663906|ref|NP_001099245.2|",2474,0,"protein disulfide-isomerase A2 precursor [Rattus norvegicus]","gi|164663905|ref|NM_001105775.2|",1671,0,"Rattus norvegicus protein disulfide isomerase family A, member 2 (Pdia2), mRNA","D3Z6P0",898,0,"Protein disulfide-isomerase A2","SPAC1F5.02",219,{"v":3e-61,"d":"3.00E-61"},"COG0526","pfam02115","Rho_GDI","RHO protein GDP dissociation inhibitor.",".",".",".",".","."]
["ENSRNOG00000062661",38,2.444556651,94,6.068814808,0.402806269,-1.311841958,{"v":6.66979e-07,"d":"6.67E-07"},{"v":5.62179e-07,"d":"5.62E-07"},"down","yes","ENSRNOG00000062661","protein_coding","chr10:107173094-107204087:+","gi|564313890|ref|XP_006221048.1|",3775,0,"PREDICTED: zinc finger protein 431-like isoform X1 [Rattus norvegicus]","gi|672025604|ref|XM_006220986.2|",2552,0,"PREDICTED: Rattus norvegicus zinc finger protein 709-like (LOC102550944), transcript variant X1, mRNA","Q8N972",724,0,"Zinc finger protein 709",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000007923",46,2.959200157,106,6.843557123,0.43240673,-1.209539118,{"v":7.27389e-07,"d":"7.27E-07"},{"v":6.11743e-07,"d":"6.12E-07"},"down","yes","Cgref1","protein_coding","chr6:25431799-25443852:+","gi|236467366|ref|NP_620787.2|",1442,0,"cell growth regulator with EF hand domain protein 1 [Rattus norvegicus]","gi|236467365|ref|NM_139087.2|",1331,0,"Rattus norvegicus cell growth regulator with EF hand domain 1 (Cgref1), mRNA","P97586",524,0,"Cell growth regulator with EF hand domain protein 1",".",".",".",".","pfam13499","EF-hand_7","EF-hand domain pair.","GO:0007155|cell adhesion;GO:0030308|negative regulation of cell growth;","GO:0005576|extracellular region;","GO:0005509|calcium ion binding;",".","."]
["ENSRNOG00000011824",7,0.450313067,39,2.517912527,0.178843809,-2.483227916,{"v":7.52498e-07,"d":"7.52E-07"},{"v":6.32301e-07,"d":"6.32E-07"},"down","yes","Trh","protein_coding","chr4:124742111-124744637:-","gi|7242211|ref|NP_037178.1|",1071,{"v":2e-141,"d":"2.00E-141"},"thyrotropin releasing hormone preproprotein [Rattus norvegicus]","gi|485464617|ref|NM_013046.3|",1391,0,"Rattus norvegicus thyrotropin releasing hormone (Trh), mRNA","P01150",417,{"v":5e-143,"d":"5.00E-143"},"Pro-thyrotropin-releasing hormone",".",".",".",".","pfam05438","TRH","Thyrotropin-releasing hormone (TRH). This family consists of several thyrotropin-releasing hormone (TRH) proteins. Thyrotropin-Releasing Hormone (TRH; pyroGlu-His-Pro-NH2), originally isolated as a hypothalamic neuropeptide hormone, most likely acts also as a neuromodulator and/or neurotransmitter in the central nervous system (CNS). This interpretation is supported by the identification of a peptidase localized on the surface of neuronal cells which has been termed TRH-degrading ectoenzyme (TRH-DE) since it selectively inactivates TRH. TRH has been used clinically for the treatment of spinocerebellar degeneration and disturbance of consciousness in humans.","GO:0001666|response to hypoxia;GO:0001692|histamine metabolic process;GO:0007628|adult walking behavior;GO:0009409|response to cold;GO:0009749|response to glucose;GO:0009755|hormone-mediated signaling pathway;GO:0014050|negative regulation of glutamate secretion;GO:0014054|positive regulation of gamma-aminobutyric acid secretion;GO:0014070|response to organic cyclic compound;GO:0032024|positive regulation of insulin secretion;GO:0042755|eating behavior;GO:0045471|response to ethanol;GO:0051412|response to corticosterone;GO:2000252|negative regulation of feeding behavior;","GO:0005576|extracellular region;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0030141|secretory granule;","GO:0008437|thyrotropin-releasing hormone activity;","K05253","TRH; thyrotropin-releasing hormone"]
["ENSRNOG00000047363",24,1.543930516,71,4.583892036,0.33681651,-1.569965238,{"v":7.65788e-07,"d":"7.66E-07"},{"v":6.4309e-07,"d":"6.43E-07"},"down","yes","Kcnk13","protein_coding","chr6:119242188-119345240:+","gi|564356934|ref|XP_006240509.1|",2078,0,"PREDICTED: potassium channel subfamily K member 13 isoform X1 [Rattus norvegicus]","gi|672056773|ref|XM_006240447.2|",2032,0,"PREDICTED: Rattus norvegicus potassium channel, subfamily K, member 13 (Kcnk13), transcript variant X2, mRNA","Q9ERS0",799,0,"Potassium channel subfamily K member 13",".",".",".",".","pfam07885","Ion_trans_2","Ion channel. This family includes the two membrane helix type ion channels found in bacteria.","GO:0030322|stabilization of membrane potential;GO:0034765|regulation of ion transmembrane transport;GO:0071805|potassium ion transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;","GO:0005244|voltage-gated ion channel activity;GO:0005267|potassium channel activity;GO:0022841|potassium ion leak channel activity;","K04922","KCNK13, K2P13.1; potassium channel subfamily K member 13"]
["ENSRNOG00000004441",20,1.286608764,64,4.131959018,0.311379846,-1.683252524,{"v":8.02632e-07,"d":"8.03E-07"},{"v":6.73139e-07,"d":"6.73E-07"},"down","yes","Fcmr","protein_coding","chr13:42337414-42351653:+","gi|149058683|gb|EDM09840.1|",2030,0,"rCG46433, isoform CRA_a [Rattus norvegicus]","gi|404247483|ref|NM_001014843.2|",1525,0,"Rattus norvegicus Fc fragment of IgM receptor (Fcmr), mRNA","Q5M871",742,0,"Fas apoptotic inhibitory molecule 3",".",".",".",".","pfam03387","Herpes_UL46","Herpesvirus UL46 protein.","GO:0002376|immune system process;GO:0070229|negative regulation of lymphocyte apoptotic process;GO:1990001|inhibition of cysteine-type endopeptidase activity involved in apoptotic process;GO:2001237|negative regulation of extrinsic apoptotic signaling pathway;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0004888|transmembrane signaling receptor activity;",".","."]
["ENSRNOG00000016535",3,0.192991315,29,1.87229393,0.103077466,-3.278199114,{"v":9.24266E-7,"d":"9.24E-07"},{"v":7.71299E-7,"d":"7.71E-07"},"down","yes","Ccl22","lncRNA","chr19:10257601-10264400:-","gi|149032436|gb|EDL87327.1|",875,{"v":7e-111,"d":"7.00E-111"},"chemokine (C-C motif) ligand 22 [Rattus norvegicus]","gi|57528025|ref|NM_057203.1|",1742,0,"Rattus norvegicus chemokine (C-C motif) ligand 22 (Ccl22), mRNA","O88430",152,{"v":2e-42,"d":"2.00E-42"},"C-C motif chemokine 22",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0002548|monocyte chemotaxis;GO:0006954|inflammatory response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0008150|biological_process;GO:0030593|neutrophil chemotaxis;GO:0031640|killing of cells of other organism;GO:0043547|positive regulation of GTPase activity;GO:0048247|lymphocyte chemotaxis;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098|chemokine-mediated signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;","GO:0005575|cellular_component;GO:0005615|extracellular space;","GO:0003674|molecular_function;GO:0008009|chemokine activity;GO:0048020|CCR chemokine receptor binding;","K21095","CCL22; C-C motif chemokine 22"]
["ENSRNOG00000003807",0,0.032165219,22,1.420360912,0.022645807,-5.464612238,{"v":1.0731e-06,"d":"1.07E-06"},{"v":8.90443E-7,"d":"8.90E-07"},"down","yes","Wnt9b","protein_coding","chr10:88635331-88657035:-","gi|880882276|ref|XP_005070115.2|",1611,0,"PREDICTED: protein Wnt-9b [Mesocricetus auratus]","gi|157820440|ref|NM_001107055.1|",4650,0,"Rattus norvegicus wingless-type MMTV integration site family, member 9B (Wnt9b), mRNA","O35468",603,0,"Protein Wnt-9b",".",".",".",".","pfam00110","wnt","wnt family. Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.","GO:0001658|branching involved in ureteric bud morphogenesis;GO:0001701|in utero embryonic development;GO:0001822|kidney development;GO:0001932|regulation of protein phosphorylation;GO:0003339|regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0008150|biological_process;GO:0009267|cellular response to starvation;GO:0009786|regulation of asymmetric cell division;GO:0016055|Wnt signaling pathway;GO:0030182|neuron differentiation;GO:0030539|male genitalia development;GO:0035150|regulation of tube size;GO:0043085|positive regulation of catalytic activity;GO:0045165|cell fate commitment;GO:0048701|embryonic cranial skeleton morphogenesis;GO:0048754|branching morphogenesis of an epithelial tube;GO:0060021|roof of mouth development;GO:0060070|canonical Wnt signaling pathway;GO:0060071|Wnt signaling pathway, planar cell polarity pathway;GO:0060993|kidney morphogenesis;GO:0061038|uterus morphogenesis;GO:0072003|kidney rudiment formation;GO:0072038|mesenchymal stem cell maintenance involved in nephron morphogenesis;GO:0072044|collecting duct development;GO:0072046|establishment of planar polarity involved in nephron morphogenesis;GO:0072078|nephron tubule morphogenesis;GO:0072164|mesonephric tubule development;GO:0072170|metanephric tubule development;GO:0072174|metanephric tubule formation;GO:0072181|mesonephric duct formation;GO:1902455|negative regulation of stem cell population maintenance;GO:1904948|midbrain dopaminergic neuron differentiation;GO:1905438|non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation;","GO:0005575|cellular_component;GO:0005615|extracellular space;","GO:0003674|molecular_function;GO:0005102|signaling receptor binding;GO:0005109|frizzled binding;GO:0005125|cytokine activity;GO:0039706|co-receptor binding;GO:0048018|receptor ligand activity;","K01064","WNT9; wingless-type MMTV integration site family, member 9"]
["ENSRNOG00000028598",0,0.032165219,22,1.420360912,0.022645807,-5.464612238,{"v":1.0731e-06,"d":"1.07E-06"},{"v":8.90443E-7,"d":"8.90E-07"},"down","yes","Edar","protein_coding","chr20:26587839-26666494:-","gi|568966645|ref|XP_006513269.1|",2036,0,"PREDICTED: tumor necrosis factor receptor superfamily member EDAR isoform X3 [Mus musculus]","gi|672086280|ref|XM_006256381.2|",3625,0,"PREDICTED: Rattus norvegicus ectodysplasin-A receptor (Edar), transcript variant X1, mRNA","Q9R187",777,0,"Tumor necrosis factor receptor superfamily member EDAR",".",".",".",".","pfam00531","Death","Death domain.","GO:0001942|hair follicle development;GO:0008150|biological_process;GO:0010628|positive regulation of gene expression;GO:0042475|odontogenesis of dentin-containing tooth;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043473|pigmentation;GO:0046330|positive regulation of JNK cascade;GO:0060662|salivary gland cavitation;GO:1901224|positive regulation of NIK/NF-kappaB signaling;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0045177|apical part of cell;","GO:0003674|molecular_function;GO:0004888|transmembrane signaling receptor activity;GO:0038023|signaling receptor activity;","K05162","EDAR; tumor necrosis factor receptor superfamily member EDAR"]
["ENSRNOG00000055773",0,0.032165219,22,1.420360912,0.022645807,-5.464612238,{"v":1.0731e-06,"d":"1.07E-06"},{"v":8.90443E-7,"d":"8.90E-07"},"down","yes","Olr1424","protein_coding","chr10:42907259-42908197:-","gi|47576059|ref|NP_001000779.1|",1519,0,"olfactory receptor Olr1424 [Rattus norvegicus]","gi|47576058|ref|NM_001000779.1|",939,0,"Rattus norvegicus olfactory receptor 1424 (Olr1424), mRNA","Q8NH02",466,{"v":4e-164,"d":"4.00E-164"},"Olfactory receptor 2T29",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0050911|detection of chemical stimulus involved in sensory perception of smell;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004984|olfactory receptor activity;","K04257","OLFR; olfactory receptor"]
["ENSRNOG00000032368",2,0.128660876,26,1.678608351,0.076647347,-3.705620337,{"v":1.07589e-06,"d":"1.08E-06"},{"v":8.91968e-07,"d":"8.92E-07"},"down","yes","Tlr11","protein_coding","chr15:23545408-23549849:+","gi|408684405|ref|NP_001138251.2|",4104,0,"toll-like receptor 11 [Rattus norvegicus]","gi|408684404|ref|NM_001144779.2|",3219,0,"Rattus norvegicus toll-like receptor 11 (Tlr11), mRNA","Q6R5P0",1326,0,"Toll-like receptor 11","alr0124_1",63.2,3E-9,"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0002224|toll-like receptor signaling pathway;GO:0006954|inflammatory response;GO:0009617|response to bacterium;GO:0045087|innate immune response;","GO:0005887|integral component of plasma membrane;","GO:0003953|NAD+ nucleosidase activity;GO:0004888|transmembrane signaling receptor activity;GO:0038023|signaling receptor activity;","K14142","TLR11; toll-like receptor 11"]
["ENSRNOG00000047455",2,0.128660876,26,1.678608351,0.076647347,-3.705620337,{"v":1.07589e-06,"d":"1.08E-06"},{"v":8.91968e-07,"d":"8.92E-07"},"down","yes","Cdhr3","protein_coding","chr6:49641813-49702017:-","gi|672020622|ref|XP_008774452.1|",3979,0,"PREDICTED: cadherin-related family member 3 isoform X1 [Rattus norvegicus]","gi|672020621|ref|XM_008776230.1|",2780,0,"PREDICTED: Rattus norvegicus similar to fat2 CG7749-PA, isoform A (LOC686932), transcript variant X1, mRNA","Q8BL00",1404,0,"Cadherin-related family member 3",".",".",".",".","pfam00028","Cadherin","Cadherin domain.","GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;","GO:0005886|plasma membrane;","GO:0005509|calcium ion binding;","K16503","CDHR3, CDH28; cadherin-related family member 3"]
["ENSRNOG00000015992",7,0.450313067,38,2.453350667,0.183550225,-2.445753211,{"v":1.29122e-06,"d":"1.29E-06"},{"v":1.064e-06,"d":"1.06E-06"},"down","yes","Ccl20","protein_coding","chr9:84388904-84391629:+","gi|564368932|ref|XP_006245226.1|",505,{"v":8e-61,"d":"8.00E-61"},"PREDICTED: C-C motif chemokine 20 isoform X1 [Rattus norvegicus]","gi|672065529|ref|XM_006245164.2|",862,0,"PREDICTED: Rattus norvegicus chemokine (C-C motif) ligand 20 (Ccl20), transcript variant X1, mRNA","P97884",194,{"v":1e-60,"d":"1.00E-60"},"C-C motif chemokine 20",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0002548|monocyte chemotaxis;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0030593|neutrophil chemotaxis;GO:0031640|killing of cells of other organism;GO:0032730|positive regulation of interleukin-1 alpha production;GO:0035584|calcium-mediated signaling using intracellular calcium source;GO:0042060|wound healing;GO:0043547|positive regulation of GTPase activity;GO:0048247|lymphocyte chemotaxis;GO:0051770|positive regulation of nitric-oxide synthase biosynthetic process;GO:0060326|cell chemotaxis;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098|chemokine-mediated signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071222|cellular response to lipopolysaccharide;GO:0071223|cellular response to lipoteichoic acid;GO:0071310|cellular response to organic substance;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0072678|T cell migration;GO:0072679|thymocyte migration;GO:2000406|positive regulation of T cell migration;","GO:0005615|extracellular space;","GO:0005125|cytokine activity;GO:0008009|chemokine activity;GO:0031731|CCR6 chemokine receptor binding;GO:0048020|CCR chemokine receptor binding;","K14625","CCL20; C-C motif chemokine 20"]
["ENSRNOG00000039656",4,0.257321753,31,2.001417649,0.128569743,-2.95937693,{"v":1.29684e-06,"d":"1.30E-06"},{"v":1.06832e-06,"d":"1.07E-06"},"down","yes","Abca17","protein_coding","chr10:13289001-13381651:-","gi|564370893|ref|XP_006245989.1|",8878,0,"PREDICTED: ATP-binding cassette, subfamily A (ABC1), member 17 isoform X1 [Rattus norvegicus]","gi|672066816|ref|XM_006245927.2|",5698,0,"PREDICTED: Rattus norvegicus ATP-binding cassette, subfamily A (ABC1), member 17 (Abca17), transcript variant X1, mRNA","E9PU17",3427,0,"ATP-binding cassette sub-family A member 17","SSO1144",171,{"v":2E-45,"d":"2.00E-45"},"COG1131","pfam00005","ABC_tran","ABC transporter. ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide or belong in different polypeptide chains.","GO:0006638|neutral lipid metabolic process;GO:0006869|lipid transport;GO:0055085|transmembrane transport;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0005319|lipid transporter activity;GO:0005524|ATP binding;GO:0042626|ATPase activity, coupled to transmembrane movement of substances;","K05643","ABCA3; ATP-binding cassette, subfamily A (ABC1), member 3"]
["ENSRNOG00000067449",19,1.222278326,61,3.938273439,0.310358929,-1.687990443,{"v":1.38413E-6,"d":"1.38E-06"},{"v":1.13777E-6,"d":"1.14E-06"},"down","yes","ENSRNOG00000067449","lncRNA","chr10:104292395-104293585:-",".",".",".",".","gi|26342293|dbj|AK051905.1|",861,0,"Mus musculus 12 days embryo eyeball cDNA, RIKEN full-length enriched library, clone:D230017K24 product:chromobox homolog 8 (Drosophila Pc class), full insert sequence",".",".",".",".",".",".",".",".","pfam15301","SLAIN","SLAIN motif-containing family. The SLAIN motif containing family is named after the presence of a SLAIN motif in SLAIN1. They are a family of microtubule plus-end tracking proteins.",".",".",".",".","."]
["ENSRNOG00000006784",8,0.514643505,40,2.582474386,0.199283102,-2.327108714,{"v":1.40645e-06,"d":"1.41E-06"},{"v":1.15528e-06,"d":"1.16E-06"},"down","yes","Sema4f","protein_coding","chr4:115411417-115437721:-","gi|9507083|ref|NP_062145.1|",3424,0,"semaphorin-4F precursor [Rattus norvegicus]","gi|9507082|ref|NM_019272.1|",3973,0,"Rattus norvegicus ssemaphorin 4F (Sema4f), mRNA","Q9Z143",1323,0,"Semaphorin-4F",".",".",".",".","pfam01403","Sema","Sema domain. The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and human plexin A-3.","GO:0001755|neural crest cell migration;GO:0007411|axon guidance;GO:0030335|positive regulation of cell migration;GO:0030517|negative regulation of axon extension;GO:0031290|retinal ganglion cell axon guidance;GO:0048843|negative regulation of axon extension involved in axon guidance;GO:0050919|negative chemotaxis;GO:0071526|semaphorin-plexin signaling pathway;","GO:0005615|extracellular space;GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0014069|postsynaptic density;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0043204|perikaryon;GO:0045202|synapse;GO:0045211|postsynaptic membrane;","GO:0030215|semaphorin receptor binding;GO:0045499|chemorepellent activity;","K06521","SEMA4, CD100; semaphorin 4"]
["ENSRNOG00000007573",18,1.157947887,59,3.80914972,0.303991172,-1.717898667,{"v":1.53502E-6,"d":"1.54E-06"},{"v":1.25764e-06,"d":"1.26E-06"},"down","yes","Hoxb9","protein_coding","chr10:81237312-81240818:+","gi|113680760|ref|NP_032296.2|",1262,{"v":6e-173,"d":"6.00E-173"},"homeobox protein Hox-B9 [Mus musculus]","gi|154756739|ref|NM_001100497.1|",937,0,"Rattus norvegicus homeo box B9 (Hoxb9), mRNA","P20615",490,{"v":2E-174,"d":"2.00E-174"},"Homeobox protein Hox-B9",".",".",".",".","pfam04617","Hox9_act","Hox9 activation region. This family constitutes the N termini of the paralogous homeobox proteins HoxA9, HoxB9, HoxC9 and HoxD9. The N terminal region is found to act as a transcription activation region. Btg1 and Btg2 - the B-cell translocation gene products - may function as cofactors for Hoxb9-mediated transcription. The Btg proteins modulate Hoxb9 transcriptional activity by recruiting a multiprotein Ccr4-like complex.","GO:0006351|transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0009952|anterior/posterior pattern specification;GO:0009954|proximal/distal pattern formation;GO:0030879|mammary gland development;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048704|embryonic skeletal system morphogenesis;GO:0048706|embryonic skeletal system development;GO:0060326|cell chemotaxis;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0090575|RNA polymerase II transcription factor complex;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:1990837|sequence-specific double-stranded DNA binding;","K09294","HOX_9; homeobox protein HoxB/C/D9"]
["ENSRNOG00000036585",17,1.093617449,57,3.680026,0.297176555,-1.750607792,{"v":1.69129e-06,"d":"1.69E-06"},{"v":1.38131e-06,"d":"1.38E-06"},"down","yes","Cfap43","protein_coding","chr1:246625262-246712443:-","gi|392345150|ref|XP_345042.5|",8492,0,"PREDICTED: WD repeat-containing protein 96 isoform X2 [Rattus norvegicus]","gi|672040662|ref|XM_345041.7|",5297,0,"PREDICTED: Rattus norvegicus cilia and flagella associated protein 43 (Cfap43), transcript variant X2, mRNA","Q8NDM7",2424,0,"Cilia- and flagella-associated protein 43",".",".",".",".","pfam13868","Trichoplein","tumor suppressor, Mitostatin. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs).","GO:0003356|regulation of cilium beat frequency;GO:0007288|sperm axoneme assembly;GO:0007420|brain development;GO:0030317|flagellated sperm motility;GO:0044458|motile cilium assembly;GO:0060271|cilium assembly;GO:0090660|cerebrospinal fluid circulation;","GO:0005576|extracellular region;GO:0005930|axoneme;GO:0097729|9+2 motile cilium;",".","K24223","CFAP43, WDR96; cilia- and flagella-associated protein 43"]
["ENSRNOG00000068617",61,3.924156729,125,8.070232457,0.486250768,-1.040227566,{"v":1.89497e-06,"d":"1.89E-06"},{"v":1.54391E-6,"d":"1.54E-06"},"down","yes","ENSRNOG00000068617","lncRNA","chr13:39245354-39251400:-",".",".",".",".","gi|74096684|gb|AC163690.4|",568,0,"Mus musculus BAC clone RP23-470F9 from chromosome 1, complete sequence",".",".",".",".",".",".",".",".","pfam03073","TspO_MBR","TspO/MBR family. Tryptophan-rich sensory protein (TspO) is an integral membrane protein that acts as a negative regulator of the expression of specific photosynthesis genes in response to oxygen/light. It is involved in the efflux of porphyrin intermediates from the cell. This reduces the activity of coproporphyrinogen III oxidase, which is thought to lead to the accumulation of a putative repressor molecule that inhibits the expression of specific photosynthesis genes. Several conserved aromatic residues are necessary for TspO function: they are thought to be involved in binding porphyrin intermediates. In, the rat mitochondrial peripheral benzodiazepine receptor (MBR) was shown to not only retain its structure within a bacterial outer membrane, but also to be able to functionally substitute for TspO in TspO- mutants, and to act in a similar manner to TspO in its in situ location: the outer mitochondrial membrane. The biological significance of MBR remains unclear, however. It is thought to be involved in a variety of cellular functions, including cholesterol transport in steroidogenic tissues.",".",".",".",".","."]
["ENSRNOG00000002303",0,0.032165219,21,1.355799053,0.023724179,-5.397498042,{"v":1.91566e-06,"d":"1.92E-06"},{"v":1.55809e-06,"d":"1.56E-06"},"down","yes","Kcnj12","protein_coding","chr10:45696849-45745492:+","gi|672067657|ref|XP_008765985.1|",2315,0,"PREDICTED: ATP-sensitive inward rectifier potassium channel 12 isoform X1 [Rattus norvegicus]","gi|672067656|ref|XM_008767763.1|",4037,0,"PREDICTED: Rattus norvegicus potassium inwardly-rectifying channel, subfamily J, member 12 (Kcnj12), transcript variant X1, mRNA","P52187",853,0,"ATP-sensitive inward rectifier potassium channel 12",".",".",".",".","pfam01007","IRK","Inward rectifier potassium channel.","GO:0006813|potassium ion transport;GO:0034765|regulation of ion transmembrane transport;GO:0051289|protein homotetramerization;GO:0071805|potassium ion transmembrane transport;GO:1990573|potassium ion import across plasma membrane;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030315|T-tubule;GO:0030425|dendrite;GO:0031224|intrinsic component of membrane;GO:0043025|neuronal cell body;","GO:0005242|inward rectifier potassium channel activity;GO:0005515|protein binding;GO:0030165|PDZ domain binding;","K05005","KCNJ12_18, KIR2.2, KIR2.6; potassium inwardly-rectifying channel subfamily J member 12/18"]
["ENSRNOG00000026910",0,0.032165219,21,1.355799053,0.023724179,-5.397498042,{"v":1.91566e-06,"d":"1.92E-06"},{"v":1.55809e-06,"d":"1.56E-06"},"down","yes","Gjb4","protein_coding","chr5:139675780-139679667:-","gi|16758886|ref|NP_446436.1|",1316,{"v":2e-177,"d":"2.00E-177"},"gap junction beta-4 protein [Rattus norvegicus]","gi|672053594|ref|XM_008763985.1|",1572,0,"PREDICTED: Rattus norvegicus gap junction protein, beta 4 (Gjb4), transcript variant X1, mRNA","P36380",511,{"v":5e-179,"d":"5.00E-179"},"Gap junction beta-4 protein",".",".",".",".","pfam00029","Connexin","Connexin.","GO:0007267|cell-cell signaling;GO:0007608|sensory perception of smell;GO:0008150|biological_process;GO:0042048|olfactory behavior;GO:0055085|transmembrane transport;GO:1990349|gap junction-mediated intercellular transport;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005887|integral component of plasma membrane;GO:0005922|connexin complex;GO:0030054|cell junction;","GO:0003674|molecular_function;GO:0005243|gap junction channel activity;","K07623","GJB4, CX30.3; gap junction beta-4 protein"]
["ENSRNOG00000029668",0,0.032165219,21,1.355799053,0.023724179,-5.397498042,{"v":1.91566e-06,"d":"1.92E-06"},{"v":1.55809e-06,"d":"1.56E-06"},"down","yes","Wfdc21","protein_coding","chr10:68627820-68633701:+","gi|33438173|dbj|BAC81506.1|",297,{"v":2e-32,"d":"2.00E-32"},"WDNM1-like protein [Rattus norvegicus]","gi|33438172|dbj|AB101676.1|",376,0,"Rattus norvegicus mRNA for WDNM1-like protein, complete cds","Q8BTE6",93.2,{"v":5e-24,"d":"5.00E-24"},"Protein Wfdc21",".",".",".",".","pfam00095","WAP","WAP-type (Whey Acidic Protein) 'four-disulfide core'.","GO:0008150|biological_process;GO:0010951|negative regulation of endopeptidase activity;GO:0019731|antibacterial humoral response;GO:0032496|response to lipopolysaccharide;GO:0034612|response to tumor necrosis factor;GO:0045087|innate immune response;GO:0050872|white fat cell differentiation;","GO:0005575|cellular_component;GO:0005615|extracellular space;","GO:0003674|molecular_function;GO:0004867|serine-type endopeptidase inhibitor activity;GO:0008047|enzyme activator activity;",".","."]
["ENSRNOG00000068547",0,0.032165219,21,1.355799053,0.023724179,-5.397498042,{"v":1.91566e-06,"d":"1.92E-06"},{"v":1.55809e-06,"d":"1.56E-06"},"down","yes","Olr1422","protein_coding","chr10:42855530-42860622:-","gi|47576063|ref|NP_001000007.1|",1449,0,"olfactory receptor Olr1422 [Rattus norvegicus]","gi|110292907|gb|AC141398.4|",1416,0,"Rattus norvegicus BAC CH230-12M22 () complete sequence","Q8NH00",415,{"v":3e-136,"d":"3.00E-136"},"Olfactory receptor 2T4",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.",".",".",".",".","."]
["ENSRNOG00000004795",6,0.385982629,35,2.259665088,0.170814087,-2.549501136,{"v":1.9662e-06,"d":"1.97E-06"},{"v":1.59715E-6,"d":"1.60E-06"},"down","yes","Pof1b","protein_coding","chrX:77683128-77749688:-","gi|157818163|ref|NP_001100404.1|",2705,0,"protein POF1B [Rattus norvegicus]","gi|157818162|ref|NM_001106934.1|",3877,0,"Rattus norvegicus premature ovarian failure 1B (Pof1b), mRNA","Q8K4L4",1017,0,"Protein POF1B",".",".",".",".","pfam10174","Cast","RIM-binding protein of the cytomatrix active zone. This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.","GO:0003382|epithelial cell morphogenesis;GO:0007015|actin filament organization;GO:0030036|actin cytoskeleton organization;GO:0070830|bicellular tight junction assembly;","GO:0005884|actin filament;GO:0005912|adherens junction;GO:0005923|bicellular tight junction;GO:0030057|desmosome;","GO:0051015|actin filament binding;","K23917","POF1B; protein POF1B"]
["ENSRNOG00000067363",2,0.128660876,25,1.614046491,0.079713241,-3.649036809,{"v":1.97576E-6,"d":"1.98E-06"},{"v":1.604E-6,"d":"1.60E-06"},"down","yes","Xkrx","protein_coding","chrX:97341152-97354759:-","gi|58866038|ref|NP_001012230.1|",2200,0,"XK-related protein 2 [Rattus norvegicus]","gi|58866037|ref|NM_001012230.1|",1800,0,"Rattus norvegicus XK related, X-linked (Xkrx), mRNA","Q5GH60",852,0,"XK-related protein 2",".",".",".",".","pfam09815","XK-related","XK-related protein. Members of this family comprise various XK-related proteins, that are involved in sodium-dependent transport of neutral amino acids or oligopeptides. These proteins are responsible for the Kx blood group system - defects results in McLeod syndrome, an X-linked multi-system disorder characterized by late onset abnormalities in the neuromuscular and hematopoietic systems.",".",".",".",".","."]
["ENSRNOG00000017525",59,3.795495853,122,7.876546878,0.481873074,-1.053274908,{"v":1.9838E-6,"d":"1.98E-06"},{"v":1.60985e-06,"d":"1.61E-06"},"down","yes","Epha1","protein_coding","chr4:71246409-71260846:-","gi|157822981|ref|NP_001101328.1|",4775,0,"ephrin type-A receptor 1 precursor [Rattus norvegicus]","gi|157822980|ref|NM_001107858.1|",3248,0,"Rattus norvegicus Eph receptor A1 (Epha1), mRNA","Q60750",1803,0,"Ephrin type-A receptor 1","YAR019c",112,{"v":3E-24,"d":"3.00E-24"},"COG0515","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001954|positive regulation of cell-matrix adhesion;GO:0006469|negative regulation of protein kinase activity;GO:0007166|cell surface receptor signaling pathway;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007275|multicellular organism development;GO:0007411|axon guidance;GO:0008284|positive regulation of cell proliferation;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0030335|positive regulation of cell migration;GO:0030336|negative regulation of cell migration;GO:0033674|positive regulation of kinase activity;GO:0034446|substrate adhesion-dependent cell spreading;GO:0043087|regulation of GTPase activity;GO:0045766|positive regulation of angiogenesis;GO:0046777|protein autophosphorylation;GO:0048013|ephrin receptor signaling pathway;GO:0051496|positive regulation of stress fiber assembly;GO:0090630|activation of GTPase activity;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0043005|neuron projection;GO:0043235|receptor complex;","GO:0001968|fibronectin binding;GO:0004672|protein kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0005003|ephrin receptor activity;GO:0005005|transmembrane-ephrin receptor activity;GO:0005524|ATP binding;GO:0019901|protein kinase binding;","K05102","EPHA1, EPH; Eph receptor A1 [EC:2.7.10.1]"]
["ENSRNOG00000019318",19,1.222278326,60,3.873711579,0.315531578,-1.664143702,{"v":2.14295E-6,"d":"2.14E-06"},{"v":1.73382e-06,"d":"1.73E-06"},"down","yes","Syt3","protein_coding","chr1:94881247-94895246:+","gi|545832328|ref|XP_003127416.2|",2143,0,"PREDICTED: synaptotagmin-3 isoform X2 [Sus scrofa]","gi|672036293|ref|XM_006228979.2|",2096,0,"PREDICTED: Rattus norvegicus synaptotagmin III (Syt3), transcript variant X2, mRNA","O35681",803,0,"Synaptotagmin-3","SPAPYUK71.03c",69.3,{"v":3E-11,"d":"3.00E-11"},"COG5038","pfam00168","C2","C2 domain.","GO:0014059|regulation of dopamine secretion;GO:0016079|synaptic vesicle exocytosis;GO:0016192|vesicle-mediated transport;GO:0017156|calcium ion regulated exocytosis;GO:0017158|regulation of calcium ion-dependent exocytosis;GO:0030154|cell differentiation;GO:0031340|positive regulation of vesicle fusion;GO:0051592|response to calcium ion;GO:0071277|cellular response to calcium ion;GO:1903861|positive regulation of dendrite extension;","GO:0005768|endosome;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030658|transport vesicle membrane;GO:0045202|synapse;GO:0070382|exocytic vesicle;GO:0098793|presynapse;GO:0099699|integral component of synaptic membrane;","GO:0000149|SNARE binding;GO:0001786|phosphatidylserine binding;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0005544|calcium-dependent phospholipid binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0019905|syntaxin binding;GO:0030276|clathrin binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0046982|protein heterodimerization activity;","K19903","SYT3; synaptotagmin-3"]
["ENSRNOG00000011145",1,0.064330438,22,1.420360912,0.045291614,-4.464612238,{"v":2.14618e-06,"d":"2.15E-06"},{"v":1.73546e-06,"d":"1.74E-06"},"down","yes","Crhr2","protein_coding","chr4:84224002-84265904:-","gi|564347008|ref|XP_006236618.1|",1839,0,"PREDICTED: corticotropin-releasing factor receptor 2 isoform X1 [Rattus norvegicus]","gi|564347011|ref|XM_006236558.1|",1616,0,"PREDICTED: Rattus norvegicus corticotropin releasing hormone receptor 2 (Crhr2), transcript variant X3, mRNA","P47866",710,0,"Corticotropin-releasing factor receptor 2",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0007015|actin filament organization;GO:0007166|cell surface receptor signaling pathway;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007188|adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007205|protein kinase C-activating G protein-coupled receptor signaling pathway;GO:0007631|feeding behavior;GO:0009755|hormone-mediated signaling pathway;GO:0010460|positive regulation of heart rate;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010700|negative regulation of norepinephrine secretion;GO:0014064|positive regulation of serotonin secretion;GO:0016525|negative regulation of angiogenesis;GO:0019233|sensory perception of pain;GO:0021549|cerebellum development;GO:0021854|hypothalamus development;GO:0030855|epithelial cell differentiation;GO:0032755|positive regulation of interleukin-6 production;GO:0032811|negative regulation of epinephrine secretion;GO:0032874|positive regulation of stress-activated MAPK cascade;GO:0033685|negative regulation of luteinizing hormone secretion;GO:0035482|gastric motility;GO:0042423|catecholamine biosynthetic process;GO:0043950|positive regulation of cAMP-mediated signaling;GO:0045777|positive regulation of blood pressure;GO:0046882|negative regulation of follicle-stimulating hormone secretion;GO:0048630|skeletal muscle tissue growth;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0060291|long-term synaptic potentiation;GO:0061179|negative regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:0071376|cellular response to corticotropin-releasing hormone stimulus;GO:0071385|cellular response to glucocorticoid stimulus;GO:0090281|negative regulation of calcium ion import;GO:0106071|positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0106072|negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:2000252|negative regulation of feeding behavior;GO:2000293|negative regulation of defecation;GO:2000573|positive regulation of DNA biosynthetic process;","GO:0005783|endoplasmic reticulum;GO:0005791|rough endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0043025|neuronal cell body;GO:0043196|varicosity;GO:0043204|perikaryon;GO:0043679|axon terminus;GO:0070852|cell body fiber;","GO:0004930|G protein-coupled receptor activity;GO:0005179|hormone activity;GO:0008528|G protein-coupled peptide receptor activity;GO:0015056|corticotrophin-releasing factor receptor activity;GO:0017046|peptide hormone binding;GO:0043404|corticotropin-releasing hormone receptor activity;","K04579","CRHR2; corticotropin releasing hormone receptor 2"]
["ENSRNOG00000005734",28,1.801252269,75,4.842139474,0.371995123,-1.426644388,{"v":2.20685e-06,"d":"2.21E-06"},{"v":1.78376e-06,"d":"1.78E-06"},"down","yes","Ssuh2","protein_coding","chr4:145503185-145521735:-","gi|564304181|ref|XP_006225066.1|",1881,0,"PREDICTED: protein SSUH2 homolog isoform X2 [Rattus norvegicus]","gi|672050719|ref|XM_006237061.2|",1125,0,"PREDICTED: Rattus norvegicus ssu-2 homolog (Ssuh2), transcript variant X2, mRNA","Q8C3L1",578,0,"Protein SSUH2 homolog",".",".",".",".","pfam00684","DnaJ_CXXCXGXG","DnaJ central domain. The central cysteine-rich (CR) domain of DnaJ proteins contains four repeats of the motif CXXCXGXG where X is any amino acid. The isolated cysteine rich domain folds in zinc dependent fashion. Each set of two repeats binds one unit of zinc. Although this domain has been implicated in substrate binding, no evidence of specific interaction between the isolated DNAJ cysteine rich domain and various hydrophobic peptides has been found.","GO:0042476|odontogenesis;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0031072|heat shock protein binding;GO:0051082|unfolded protein binding;",".","."]
["ENSRNOG00000014816",7,0.450313067,37,2.388788807,0.188511042,-2.407279063,{"v":2.20918e-06,"d":"2.21E-06"},{"v":1.78488e-06,"d":"1.78E-06"},"down","yes","Slc1a1","protein_coding","chr1:226549842-226630402:+","gi|148747368|ref|NP_037164.3|",2470,0,"excitatory amino acid transporter 3 [Rattus norvegicus]","gi|1072115|gb|U39555.1|RNU39555",2251,0,"Rattus norvegicus high affinity glutamate transporter EAAC1 mRNA, complete cds","P51907",956,0,"Excitatory amino acid transporter 3","aq_1330",189,{"v":3E-52,"d":"3.00E-52"},"COG1301","pfam00375","SDF","Sodium:dicarboxylate symporter family.","GO:0001662|behavioral fear response;GO:0001932|regulation of protein phosphorylation;GO:0001975|response to amphetamine;GO:0002027|regulation of heart rate;GO:0006749|glutathione metabolic process;GO:0006750|glutathione biosynthetic process;GO:0006801|superoxide metabolic process;GO:0006882|cellular zinc ion homeostasis;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007212|dopamine receptor signaling pathway;GO:0007215|glutamate receptor signaling pathway;GO:0007420|brain development;GO:0007611|learning or memory;GO:0007613|memory;GO:0007625|grooming behavior;GO:0007626|locomotory behavior;GO:0009410|response to xenobiotic stimulus;GO:0010460|positive regulation of heart rate;GO:0010467|gene expression;GO:0010842|retina layer formation;GO:0015813|L-glutamate transmembrane transport;GO:0018105|peptidyl-serine phosphorylation;GO:0019221|cytokine-mediated signaling pathway;GO:0022008|neurogenesis;GO:0030534|adult behavior;GO:0032148|activation of protein kinase B activity;GO:0034599|cellular response to oxidative stress;GO:0035633|maintenance of permeability of blood-brain barrier;GO:0036293|response to decreased oxygen levels;GO:0036475|neuron death in response to oxidative stress;GO:0042417|dopamine metabolic process;GO:0042883|cysteine transport;GO:0043278|response to morphine;GO:0043524|negative regulation of neuron apoptotic process;GO:0045184|establishment of protein localization;GO:0048514|blood vessel morphogenesis;GO:0048678|response to axon injury;GO:0050808|synapse organization;GO:0051938|L-glutamate import;GO:0060013|righting reflex;GO:0060041|retina development in camera-type eye;GO:0060047|heart contraction;GO:0060291|long-term synaptic potentiation;GO:0061744|motor behavior;GO:0070777|D-aspartate transport;GO:0070778|L-aspartate transmembrane transport;GO:0070779|D-aspartate import across plasma membrane;GO:0070997|neuron death;GO:0071242|cellular response to ammonium ion;GO:0071288|cellular response to mercury ion;GO:0071314|cellular response to cocaine;GO:0071407|cellular response to organic cyclic compound;GO:0071577|zinc ion transmembrane transport;GO:0072347|response to anesthetic;GO:0090313|regulation of protein targeting to membrane;GO:0090461|glutamate homeostasis;GO:0097049|motor neuron apoptotic process;GO:0098712|L-glutamate import across plasma membrane;GO:0098877|neurotransmitter receptor transport to plasma membrane;GO:0140009|L-aspartate import across plasma membrane;GO:1902476|chloride transmembrane transport;GO:1903712|cysteine transmembrane transport;GO:1990708|conditioned place preference;","GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0016324|apical plasma membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0031901|early endosome membrane;GO:0031902|late endosome membrane;GO:0031982|vesicle;GO:0032279|asymmetric synapse;GO:0043025|neuronal cell body;GO:0043083|synaptic cleft;GO:0043197|dendritic spine;GO:0043198|dendritic shaft;GO:0043204|perikaryon;GO:0043679|axon terminus;GO:0045121|membrane raft;GO:0045202|synapse;GO:0055037|recycling endosome;GO:0055038|recycling endosome membrane;GO:0071944|cell periphery;GO:0097386|glial cell projection;GO:0097440|apical dendrite;GO:0098793|presynapse;GO:0099544|perisynaptic space;GO:0150002|distal dendrite;GO:1990635|proximal dendrite;","GO:0005253|anion channel activity;GO:0005313|L-glutamate transmembrane transporter activity;GO:0005314|high-affinity glutamate transmembrane transporter activity;GO:0005515|protein binding;GO:0015108|chloride transmembrane transporter activity;GO:0015183|L-aspartate transmembrane transporter activity;GO:0015501|glutamate:sodium symporter activity;GO:0016595|glutamate binding;GO:0033229|cysteine transmembrane transporter activity;GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0140010|D-aspartate transmembrane transporter activity;","K05612","SLC1A1, EAAT3; solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter), member 1"]
["ENSRNOG00000008467",22,1.41526964,65,4.196520878,0.337248326,-1.568116814,{"v":2.28617e-06,"d":"2.29E-06"},{"v":1.84448E-6,"d":"1.84E-06"},"down","yes","Agbl2","protein_coding","chr3:76764238-76800214:+","gi|672017426|ref|XP_008773752.1|",4157,0,"PREDICTED: cytosolic carboxypeptidase 2 isoform X1 [Rattus norvegicus]","gi|672046238|ref|XM_008762015.1|",2895,0,"PREDICTED: Rattus norvegicus ATP/GTP binding protein-like 2 (Agbl2), transcript variant X2, mRNA","Q8CDK2",1484,0,"Cytosolic carboxypeptidase 2","NMA1274",96.7,{"v":3e-20,"d":"3.00E-20"},"COG2866","pfam00246","Peptidase_M14","Zinc carboxypeptidase.","GO:0006508|proteolysis;GO:0035610|protein side chain deglutamylation;","GO:0005814|centriole;GO:0005829|cytosol;GO:0036064|ciliary basal body;","GO:0004181|metallocarboxypeptidase activity;GO:0008270|zinc ion binding;","K23437","AGBL2_3, CCP2_3; cytosolic carboxypeptidase protein 2/3 [EC:3.4.17.-]"]
["ENSRNOG00000024711",22,1.41526964,65,4.196520878,0.337248326,-1.568116814,{"v":2.28617e-06,"d":"2.29E-06"},{"v":1.84448E-6,"d":"1.84E-06"},"down","yes","Sdk2","protein_coding","chr10:98828348-99101759:-","gi|564375121|ref|XP_006247755.1|",10973,0,"PREDICTED: protein sidekick-2 isoform X1 [Rattus norvegicus]","gi|672069829|ref|XM_006247693.2|",7552,0,"PREDICTED: Rattus norvegicus sidekick cell adhesion molecule 2 (Sdk2), transcript variant X1, mRNA","Q6V4S5",4196,0,"Protein sidekick-2",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007416|synapse assembly;GO:0010842|retina layer formation;GO:0060219|camera-type eye photoreceptor cell differentiation;","GO:0016021|integral component of membrane;GO:0045202|synapse;",".","K16353","SDK; protein sidekick"]
["ENSRNOG00000025634",37,2.380226213,89,5.746005509,0.414240155,-1.271460685,{"v":2.34958e-06,"d":"2.35E-06"},{"v":1.89403E-6,"d":"1.89E-06"},"down","yes","Zfhx2","protein_coding","chr15:28533156-28565128:-","gi|149274619|ref|NP_001092273.1|",7718,0,"zinc finger homeobox protein 2 [Rattus norvegicus]","gi|755548270|ref|XM_006518979.2|",7051,0,"PREDICTED: Mus musculus zinc finger homeobox 2 (Zfhx2), transcript variant X2, mRNA","Q2MHN3",2796,0,"Zinc finger homeobox protein 2","ECU06g0500",57,6e-08,"COG5576","pfam00046","Homeobox","Homeobox domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0007420|brain development;GO:0030534|adult behavior;GO:0045664|regulation of neuron differentiation;GO:0051930|regulation of sensory perception of pain;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0008270|zinc ion binding;","K09379","ZFHX2; zinc finger homeobox protein 2"]
["ENSRNOG00000014035",47,3.023530595,104,6.714433404,0.450303162,-1.151031486,{"v":2.39144e-06,"d":"2.39E-06"},{"v":1.9256e-06,"d":"1.93E-06"},"down","yes","Arhgef4","protein_coding","chr9:36861835-37005075:+","gi|672023887|ref|XP_008756228.1|",7571,0,"PREDICTED: rho guanine nucleotide exchange factor 4 isoform X1 [Rattus norvegicus]","gi|672023886|ref|XM_008758006.1|",6134,0,"PREDICTED: Rattus norvegicus Rho guanine nucleotide exchange factor (GEF) 4 (Arhgef4), transcript variant X1, mRNA","Q9NR80",1148,0,"Rho guanine nucleotide exchange factor 4",".",".",".",".","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0030032|lamellipodium assembly;GO:0035556|intracellular signal transduction;GO:0046847|filopodium assembly;GO:0050790|regulation of catalytic activity;",".","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0019904|protein domain specific binding;","K05769","ARHGEF4_29, ASEF1_2; Rho guanine nucleotide exchange factor 4/29"]
["ENSRNOG00000006486",10,0.643304382,43,2.776159965,0.231724537,-2.109517279,{"v":2.49829E-6,"d":"2.50E-06"},{"v":2.00795E-6,"d":"2.01E-06"},"down","yes","Reg1a","protein_coding","chr4:110892453-110895570:+","gi|6981470|ref|NP_036773.1|",884,{"v":2e-115,"d":"2.00E-115"},"lithostathine precursor [Rattus norvegicus]","gi|298911377|emb|FQ219465.1|",1073,0,"Rattus norvegicus TL0ABA45YB05 mRNA sequence","P10758",345,{"v":6e-117,"d":"6.00E-117"},"Lithostathine",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0001666|response to hypoxia;GO:0001934|positive regulation of protein phosphorylation;GO:0003309|type B pancreatic cell differentiation;GO:0007494|midgut development;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0010467|gene expression;GO:0010628|positive regulation of gene expression;GO:0014065|phosphatidylinositol 3-kinase signaling;GO:0014070|response to organic cyclic compound;GO:0031667|response to nutrient levels;GO:0042060|wound healing;GO:0043434|response to peptide hormone;GO:0044278|cell wall disruption in other organism;GO:0055074|calcium ion homeostasis;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0097421|liver regeneration;GO:1903492|response to acetylsalicylate;GO:1903861|positive regulation of dendrite extension;GO:1904692|positive regulation of type B pancreatic cell proliferation;GO:1904699|positive regulation of acinar cell proliferation;GO:1990785|response to water-immersion restraint stress;GO:1990798|pancreas regeneration;GO:1990864|response to growth hormone-releasing hormone;GO:1990867|response to gastrin;GO:1990869|cellular response to chemokine;GO:1990878|cellular response to gastrin;","GO:0005615|extracellular space;GO:0005829|cytosol;GO:0030426|growth cone;GO:0032590|dendrite membrane;GO:0032809|neuronal cell body membrane;GO:0032991|protein-containing complex;GO:0042588|zymogen granule;GO:0045178|basal part of cell;GO:0048471|perinuclear region of cytoplasm;","GO:0005102|signaling receptor binding;GO:0005515|protein binding;GO:0008083|growth factor activity;GO:0019902|phosphatase binding;GO:0019903|protein phosphatase binding;GO:0038023|signaling receptor activity;GO:0042802|identical protein binding;GO:0042834|peptidoglycan binding;GO:0070492|oligosaccharide binding;",".","."]
["ENSRNOG00000025925",10,0.643304382,43,2.776159965,0.231724537,-2.109517279,{"v":2.49829E-6,"d":"2.50E-06"},{"v":2.00795E-6,"d":"2.01E-06"},"down","yes","Txk","protein_coding","chr14:35463944-35519448:+","gi|66730395|ref|NP_001019426.1|",2728,0,"tyrosine-protein kinase TXK [Rattus norvegicus]","gi|66730394|ref|NM_001024255.1|",2281,0,"Rattus norvegicus TXK tyrosine kinase (Txk), mRNA","P42682",958,0,"Tyrosine-protein kinase TXK",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001819|positive regulation of cytokine production;GO:0001865|NK T cell differentiation;GO:0002250|adaptive immune response;GO:0006468|protein phosphorylation;GO:0007202|activation of phospholipase C activity;GO:0007229|integrin-mediated signaling pathway;GO:0008150|biological_process;GO:0010468|regulation of gene expression;GO:0010543|regulation of platelet activation;GO:0032729|positive regulation of interferon-gamma production;GO:0038083|peptidyl-tyrosine autophosphorylation;GO:0042246|tissue regeneration;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046777|protein autophosphorylation;GO:0050852|T cell receptor signaling pathway;GO:0060335|positive regulation of interferon-gamma-mediated signaling pathway;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0003674|molecular_function;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0005524|ATP binding;","K08016","TXK, RLK; tyrosine-protein kinase TXK [EC:2.7.10.2]"]
["ENSRNOG00000023007",29,1.865582707,76,4.906701334,0.380211181,-1.395127138,{"v":2.79686E-6,"d":"2.80E-06"},{"v":2.23659E-6,"d":"2.24E-06"},"down","yes","Col6a6","protein_coding","chr8:106306422-106473472:-","gi|672023292|ref|XP_008756083.1|",10826,0,"PREDICTED: collagen alpha-6(VI) chain isoform X1 [Rattus norvegicus]","gi|672023297|ref|XM_008757863.1|",4258,0,"PREDICTED: Rattus norvegicus collagen, type VI, alpha 6 (Col6a6), transcript variant X5, mRNA","Q8C6K9",3864,0,"Collagen alpha-6(VI) chain",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0030198|extracellular matrix organization;","GO:0005576|extracellular region;GO:0031012|extracellular matrix;",".","K06238","COL6A; collagen type VI alpha"]
["ENSRNOG00000052445",38,2.444556651,90,5.810567369,0.42070877,-1.249106202,{"v":2.84297e-06,"d":"2.84E-06"},{"v":2.27187e-06,"d":"2.27E-06"},"down","yes","Kdm7a","protein_coding","chr4:67904307-67966998:-","gi|157909789|ref|NP_001028602.2|",4312,0,"lysine-specific demethylase 7A [Mus musculus]","gi|160333388|ref|NM_001033430.4|",3454,0,"Mus musculus lysine (K)-specific demethylase 7A (Kdm7a), mRNA","Q3UWM4",1665,0,"Lysine-specific demethylase 7A",".",".",".",".","pfam00628","PHD","PHD-finger. PHD folds into an interleaved type of Zn-finger chelating 2 Zn ions in a similar manner to that of the RING and FYVE domains. Several PHD fingers have been identified as binding modules of methylated histone H3.",".",".",".",".","."]
["ENSRNOG00000033722",45,2.894869718,100,6.456185966,0.448386979,-1.157183713,{"v":3.39522e-06,"d":"3.40E-06"},{"v":2.69884e-06,"d":"2.70E-06"},"down","yes","Rnf207","protein_coding","chr5:162815357-162828375:-","gi|109475832|ref|XP_001075996.1|",3343,0,"PREDICTED: RING finger protein 207 isoform X2 [Rattus norvegicus]","gi|672055058|ref|XM_001075996.5|",2486,0,"PREDICTED: Rattus norvegicus ring finger protein 207 (Rnf207), transcript variant X2, mRNA","Q3V3A7",1221,0,"RING finger protein 207",".",".",".",".","pfam00643","zf-B_box","B-box zinc finger.","GO:0008150|biological_process;GO:0010628|positive regulation of gene expression;GO:0055117|regulation of cardiac muscle contraction;GO:1901018|positive regulation of potassium ion transmembrane transporter activity;GO:1901207|regulation of heart looping;GO:1902261|positive regulation of delayed rectifier potassium channel activity;GO:1903762|positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization;GO:1903954|positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization;","GO:0005575|cellular_component;GO:0048471|perinuclear region of cytoplasm;","GO:0003674|molecular_function;GO:0008270|zinc ion binding;GO:0030544|Hsp70 protein binding;GO:0044325|ion channel binding;GO:0051087|chaperone binding;",".","."]
["ENSRNOG00000048321",0,0.032165219,20,1.291237193,0.024910388,-5.327108714,{"v":3.4332E-6,"d":"3.43E-06"},{"v":2.72519e-06,"d":"2.73E-06"},"down","yes","Tnfsf8","protein_coding","chr5:77251373-77277421:-","gi|974987285|ref|NP_001305962.1|",1157,{"v":4e-146,"d":"4.00E-146"},"tumor necrosis factor superfamily member 8 [Rattus norvegicus]","gi|672019461|ref|XM_006225345.2|",2905,0,"PREDICTED: Rattus norvegicus tumor necrosis factor (ligand) superfamily, member 8 (Tnfsf8), transcript variant X2, mRNA","P32972",397,{"v":1E-127,"d":"1.00E-127"},"Tumor necrosis factor ligand superfamily member 8",".",".",".",".","pfam00229","TNF","TNF(tumor Necrosis Factor) family.","GO:0043374|CD8-positive, alpha-beta T cell differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050830|defense response to Gram-positive bacterium;","GO:0016021|integral component of membrane;","GO:0005164|tumor necrosis factor receptor binding;","K05471","TNFSF8, CD153; tumor necrosis factor ligand superfamily member 8"]
["ENSRNOG00000069373",0,0.032165219,20,1.291237193,0.024910388,-5.327108714,{"v":3.4332E-6,"d":"3.43E-06"},{"v":2.72519e-06,"d":"2.73E-06"},"down","yes","Hist1h2bc","protein_coding","chr17:42694723-42696642:-","gi|821141378|ref|XP_012376417.1|",466,{"v":2e-56,"d":"2.00E-56"},"PREDICTED: histone H2B type 1-K-like [Dasypus novemcinctus]","gi|672082124|ref|XM_008771769.1|",441,0,"PREDICTED: Rattus norvegicus histone cluster 1, H2bc-like 1 (Hist1h2bcl1), mRNA","Q99877",183,{"v":8e-58,"d":"8.00E-58"},"Histone H2B type 1-N",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.",".",".",".",".","."]
["ENSRNOG00000070169",0,0.032165219,20,1.291237193,0.024910388,-5.327108714,{"v":3.4332E-6,"d":"3.43E-06"},{"v":2.72519e-06,"d":"2.73E-06"},"down","yes","ENSRNOG00000070169","protein_coding","chr4:96997683-96999983:+","gi|351701099|gb|EHB04018.1|",435,{"v":5E-52,"d":"5.00E-52"},"Ig kappa chain V-V region L6 [Heterocephalus glaber]","gi|672088081|ref|XM_008773381.1|",224,{"v":4e-112,"d":"4.00E-112"},"PREDICTED: Rattus norvegicus Ig kappa chain V-V region L6-like (LOC103690610), transcript variant X2, mRNA","P01638",157,{"v":5e-48,"d":"5.00E-48"},"Ig kappa chain V-V region L6 (Fragment)",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000023941",30,1.929913146,77,4.971263193,0.388213834,-1.365076564,{"v":3.51057e-06,"d":"3.51E-06"},{"v":2.7851e-06,"d":"2.79E-06"},"down","yes","Fam178b","protein_coding","chr9:38805864-38913672:-","gi|564368128|ref|XP_006244904.1|",2683,0,"PREDICTED: protein FAM178B isoform X2 [Rattus norvegicus]","gi|672064929|ref|XM_006244842.2|",2326,0,"PREDICTED: Rattus norvegicus family with sequence similarity 178, member B (Fam178b), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam14816","FAM178","Family of unknown function, FAM178.",".",".",".",".","."]
["ENSRNOG00000002624",2,0.128660876,24,1.549484632,0.083034626,-3.59014312,{"v":3.62814e-06,"d":"3.63E-06"},{"v":2.87439e-06,"d":"2.87E-06"},"down","yes","Edaradd","protein_coding","chr17:85656905-85910447:-","gi|392334034|ref|XP_001054456.3|",1099,{"v":3e-140,"d":"3.00E-140"},"PREDICTED: ectodysplasin-A receptor-associated adapter protein isoform X2 [Rattus norvegicus]","gi|672082657|ref|XM_574055.6|",2117,0,"PREDICTED: Rattus norvegicus EDAR-associated death domain (Edaradd), transcript variant X2, mRNA","Q8VHX2",372,{"v":3e-120,"d":"3.00E-120"},"Ectodysplasin-A receptor-associated adapter protein",".",".",".",".","pfam00531","Death","Death domain.","GO:0001942|hair follicle development;GO:0007165|signal transduction;GO:0042475|odontogenesis of dentin-containing tooth;GO:0061153|trachea gland development;GO:1901224|positive regulation of NIK/NF-kappaB signaling;",".",".","K23324","EDARADD; ectodysplasin-A receptor-associated adapter protein"]
["ENSRNOG00000002583",1,0.064330438,21,1.355799053,0.047448358,-4.397498042,{"v":3.95118e-06,"d":"3.95E-06"},{"v":3.11906e-06,"d":"3.12E-06"},"down","yes","Serpinb11","protein_coding","chr13:23304456-23344604:+","gi|672073712|ref|XP_006249695.2|",2187,0,"PREDICTED: serpin B11 isoform X2 [Rattus norvegicus]","gi|672073711|ref|XM_006249633.2|",1737,0,"PREDICTED: Rattus norvegicus serpin peptidase inhibitor, clade B (ovalbumin), member 11 (Serpinb11), transcript variant X2, mRNA","Q9CQV3",711,0,"Serpin B11","MA2246",169,{"v":4e-45,"d":"4.00E-45"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0010951|negative regulation of endopeptidase activity;","GO:0005615|extracellular space;","GO:0004867|serine-type endopeptidase inhibitor activity;","K13966","SERPINB11_12; serpin B11/12"]
["ENSRNOG00000008161",1,0.064330438,21,1.355799053,0.047448358,-4.397498042,{"v":3.95118e-06,"d":"3.95E-06"},{"v":3.11906e-06,"d":"3.12E-06"},"down","yes","Pdzk1ip1","protein_coding","chr5:128618237-128623131:+","gi|672053512|ref|XP_008762190.1|",714,{"v":3e-91,"d":"3.00E-91"},"PREDICTED: PDZK1-interacting protein 1 isoform X2 [Rattus norvegicus]","gi|672053511|ref|XM_008763968.1|",881,0,"PREDICTED: Rattus norvegicus PDZK1 interacting protein 1 (Pdzk1ip1), transcript variant X1, mRNA","Q923S2",161,{"v":1e-47,"d":"1.00E-47"},"PDZK1-interacting protein 1",".",".",".",".","pfam11725","AvrE","Pathogenicity factor. This family is secreted by gram-negative Gammaproteobacteria such as Pseudomonas syringae of tomato and the fire blight plant pathogen Erwinia amylovora, amongst others. It is an essential pathogenicity factor of approximately 198 kDa. Its injection into the host-plant is dependent upon the bacterial type III or Hrp secretion system. The family is long and carries a number of predicted functional regions, including an ERMS or endoplasmic reticulum membrane retention signal at both the C- and the N-termini, a leucine-zipper motif from residues 539-560, and a nuclear localisation signal at 1358-1361. this conserved AvrE-family of effectors is among the few that are required for full virulence of many phytopathogenic pseudomonads, erwinias and pantoeas.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000057322",1,0.064330438,21,1.355799053,0.047448358,-4.397498042,{"v":3.95118e-06,"d":"3.95E-06"},{"v":3.11906e-06,"d":"3.12E-06"},"down","yes","Efna3","protein_coding","chr2:174729764-174738736:-","gi|117935036|ref|NP_034238.1|",1091,{"v":2E-140,"d":"2.00E-140"},"ephrin-A3 precursor [Mus musculus]","gi|564300557|ref|XM_001072657.4|",1669,0,"PREDICTED: Rattus norvegicus ephrin A3 (Efna3), mRNA","O08545",424,{"v":7e-142,"d":"7.00E-142"},"Ephrin-A3",".",".",".",".","pfam00812","Ephrin","Ephrin.","GO:0007411|axon guidance;GO:0016525|negative regulation of angiogenesis;GO:0045664|regulation of neuron differentiation;GO:0048013|ephrin receptor signaling pathway;GO:1902961|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process;","GO:0005886|plasma membrane;GO:0031225|anchored component of membrane;","GO:0046875|ephrin receptor binding;","K05462","EFNA; ephrin-A"]
["ENSRNOG00000058912",21,1.350939202,62,4.002835299,0.337495575,-1.567059507,{"v":3.95559E-6,"d":"3.96E-06"},{"v":3.12168E-6,"d":"3.12E-06"},"down","yes","ENSRNOG00000058912","protein_coding","chr20:5808860-5840172:+","gi|114145706|ref|NP_001041404.1|",2899,0,"uncharacterized protein LOC499407 [Rattus norvegicus]","gi|114145705|ref|NM_001047939.1|",2650,0,"Rattus norvegicus LRRGT00097 (LOC499407), mRNA",".",".",".",".",".",".",".",".","pfam11575","FhuF_C","FhuF 2Fe-2S C-terminal domain. This family consists of several bacterial ferric iron reductase protein (FhuF) sequences.  FhuF is involved in the reduction of ferric iron in cytoplasmic ferrioxamine B. This domain is the C-terminal domain that contains 4 conserved cysteine residues that are found to be part of a 2Fe-2S cluster.",".",".",".",".","."]
["ENSRNOG00000049388",10,0.643304382,42,2.711598106,0.237241788,-2.075569947,{"v":4.11811e-06,"d":"4.12E-06"},{"v":3.24411e-06,"d":"3.24E-06"},"down","yes","Prr32","protein_coding","chrX:123977985-123979942:+","gi|109512588|ref|XP_001067334.1|",1405,0,"PREDICTED: proline-rich protein 32 [Rattus norvegicus]","gi|672032738|ref|XM_001067334.5|",1128,0,"PREDICTED: Rattus norvegicus proline rich 32 (Prr32), mRNA",".",".",".",".",".",".",".",".","pfam15488","DUF4645","Domain of unknown function (DUF4645). This family of proteins is found in eukaryotes. Proteins in this family are typically between 200 and 298 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000019099",58,3.731165415,118,7.618299439,0.489763555,-1.029842674,{"v":4.41059e-06,"d":"4.41E-06"},{"v":3.46591E-6,"d":"3.47E-06"},"down","yes","AABR07054578.1","protein_coding","chr3:154113561-154125057:-","gi|564302859|ref|XP_006224805.1|",3622,0,"PREDICTED: zinc finger protein 334 [Rattus norvegicus]","gi|672017738|ref|XM_008775620.1|",4064,0,"PREDICTED: Rattus norvegicus zinc finger protein 334 (LOC685574), transcript variant X1, mRNA","Q9HCZ1",976,0,"Zinc finger protein 334",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000021048",16,1.029287011,53,3.421778562,0.300804682,-1.733101074,{"v":4.56407e-06,"d":"4.56E-06"},{"v":3.58258e-06,"d":"3.58E-06"},"down","yes","AC095693.1","protein_coding","chr1:96260977-96280672:+","gi|672036760|ref|XP_008757681.1|",3275,0,"PREDICTED: serine/threonine-protein kinase LMTK3 isoform X2 [Rattus norvegicus]","gi|755521105|ref|XM_006540961.2|",4544,0,"PREDICTED: Mus musculus lemur tyrosine kinase 3 (Lmtk3), transcript variant X2, mRNA","Q5XJV6",1205,0,"Serine/threonine-protein kinase LMTK3",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.",".",".",".",".","."]
["ENSRNOG00000030034",5,0.321652191,31,2.001417649,0.160712179,-2.637448835,{"v":5.08651e-06,"d":"5.09E-06"},{"v":3.97954E-6,"d":"3.98E-06"},"down","yes","Sox11","protein_coding","chr6:44008340-44010354:-","gi|880946384|ref|XP_012977427.1|",1316,{"v":2e-173,"d":"2.00E-173"},"PREDICTED: transcription factor SOX-11 [Mesocricetus auratus]","gi|16758067|ref|NM_053349.1|",1967,0,"Rattus norvegicus SRY box 11 (Sox11), mRNA","P0C1G9",504,{"v":4e-172,"d":"4.00E-172"},"Transcription factor SOX-11",".",".",".",".","pfam00505","HMG_box","HMG (high mobility group) box.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001501|skeletal system development;GO:0001822|kidney development;GO:0001841|neural tube formation;GO:0002089|lens morphogenesis in camera-type eye;GO:0003151|outflow tract morphogenesis;GO:0003211|cardiac ventricle formation;GO:0003357|noradrenergic neuron differentiation;GO:0006355|regulation of transcription, DNA-templated;GO:0008283|cell proliferation;GO:0008284|positive regulation of cell proliferation;GO:0009653|anatomical structure morphogenesis;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0014003|oligodendrocyte development;GO:0014009|glial cell proliferation;GO:0014032|neural crest cell development;GO:0017015|regulation of transforming growth factor beta receptor signaling pathway;GO:0021510|spinal cord development;GO:0021782|glial cell development;GO:0030154|cell differentiation;GO:0030182|neuron differentiation;GO:0030513|positive regulation of BMP signaling pathway;GO:0035332|positive regulation of hippo signaling;GO:0035914|skeletal muscle cell differentiation;GO:0045666|positive regulation of neuron differentiation;GO:0045669|positive regulation of osteoblast differentiation;GO:0045778|positive regulation of ossification;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046887|positive regulation of hormone secretion;GO:0048485|sympathetic nervous system development;GO:0048557|embryonic digestive tract morphogenesis;GO:0048704|embryonic skeletal system morphogenesis;GO:0050672|negative regulation of lymphocyte proliferation;GO:0050769|positive regulation of neurogenesis;GO:0060022|hard palate development;GO:0060023|soft palate development;GO:0060174|limb bud formation;GO:0060253|negative regulation of glial cell proliferation;GO:0060412|ventricular septum morphogenesis;GO:0060425|lung morphogenesis;GO:0060548|negative regulation of cell death;GO:0060563|neuroepithelial cell differentiation;GO:0061029|eyelid development in camera-type eye;GO:0061053|somite development;GO:0061303|cornea development in camera-type eye;GO:0061386|closure of optic fissure;GO:2000648|positive regulation of stem cell proliferation;GO:2000678|negative regulation of transcription regulatory region DNA binding;GO:2001111|positive regulation of lens epithelial cell proliferation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987|proximal promoter sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0005515|protein binding;","K09268","SOX11_12; transcription factor SOX11/12 (SOX group C)"]
["ENSRNOG00000021097",3,0.192991315,26,1.678608351,0.11497102,-3.120657837,{"v":5.48075E-6,"d":"5.48E-06"},{"v":4.2746e-06,"d":"4.27E-06"},"down","yes","Hpn","protein_coding","chr1:86337087-86352811:-","gi|159110512|ref|NP_001103722.1|",2246,0,"serine protease hepsin isoform 1 precursor [Mus musculus]","gi|298906207|emb|FQ219040.1|",1602,0,"Rattus norvegicus TL0ABA48YC09 mRNA sequence","O35453",869,0,"Serine protease hepsin","VC1649",108,{"v":4e-24,"d":"4.00E-24"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;GO:0007605|sensory perception of sound;GO:0008360|regulation of cell shape;GO:0010628|positive regulation of gene expression;GO:0010693|negative regulation of alkaline phosphatase activity;GO:0010719|negative regulation of epithelial to mesenchymal transition;GO:0010756|positive regulation of plasminogen activation;GO:0030307|positive regulation of cell growth;GO:0034769|basement membrane disassembly;GO:0042632|cholesterol homeostasis;GO:0043066|negative regulation of apoptotic process;GO:0043923|positive regulation by host of viral transcription;GO:0050680|negative regulation of epithelial cell proliferation;GO:0050910|detection of mechanical stimulus involved in sensory perception of sound;GO:0060429|epithelium development;GO:0071805|potassium ion transmembrane transport;GO:0090103|cochlea morphogenesis;GO:0097066|response to thyroid hormone;GO:0097195|pilomotor reflex;GO:2000347|positive regulation of hepatocyte proliferation;GO:2000611|positive regulation of thyroid hormone generation;","GO:0005737|cytoplasm;GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005911|cell-cell junction;GO:0009986|cell surface;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0031965|nuclear membrane;GO:0043025|neuronal cell body;","GO:0004252|serine-type endopeptidase activity;GO:0008233|peptidase activity;GO:0008236|serine-type peptidase activity;GO:0070008|serine-type exopeptidase activity;","K08665","HPN; hepsin [EC:3.4.21.106]"]
["ENSRNOG00000068984",3,0.192991315,26,1.678608351,0.11497102,-3.120657837,{"v":5.48075E-6,"d":"5.48E-06"},{"v":4.2746e-06,"d":"4.27E-06"},"down","yes","Gbp1","protein_coding","chr2:231398163-231432131:+","gi|564301074|ref|XP_006224340.1|",3824,0,"PREDICTED: interferon-induced guanylate-binding protein 1 [Rattus norvegicus]","gi|672016387|ref|XM_006224278.2|",2616,0,"PREDICTED: Rattus norvegicus guanylate binding protein 1, interferon-inducible (Gbp1), transcript variant X1, mRNA","Q5D1D6",855,0,"Guanylate-binding protein 1",".",".",".",".","pfam02263","GBP","Guanylate-binding protein, N-terminal domain. Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.",".",".",".",".","."]
["ENSRNOG00000018853",13,0.836295696,47,3.034407404,0.275604289,-1.859329753,{"v":5.87521e-06,"d":"5.88E-06"},{"v":4.5703e-06,"d":"4.57E-06"},"down","yes","Slc28a3","protein_coding","chr17:6062549-6114038:+","gi|672080833|ref|XP_008769644.1|",3530,0,"PREDICTED: solute carrier family 28 member 3 isoform X1 [Rattus norvegicus]","gi|672080832|ref|XM_008771422.1|",2470,0,"PREDICTED: Rattus norvegicus solute carrier family 28 (concentrative nucleoside transporter), member 3 (Slc28a3), transcript variant X1, mRNA","Q8VIH3",1335,0,"Solute carrier family 28 member 3","all0378",306,{"v":3e-92,"d":"3.00E-92"},"COG1972","pfam07662","Nucleos_tra2_C","Na+ dependent nucleoside transporter C-terminus. This family consists of nucleoside transport proteins. Members include a purine-specific Na+-nucleoside cotransporter localized to the bile canalicular membrane and a Na+-dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine, which also transports the anti-viral nucleoside analogues AZT and ddC. This alignment covers the C-terminus of this family of transporters.","GO:0001895|retina homeostasis;GO:0015855|pyrimidine nucleobase transport;GO:0015860|purine nucleoside transmembrane transport;GO:0015862|uridine transport;GO:0015864|pyrimidine nucleoside transport;GO:0035725|sodium ion transmembrane transport;GO:0072531|pyrimidine-containing compound transmembrane transport;GO:1901642|nucleoside transmembrane transport;GO:1904823|purine nucleobase transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0031526|brush border membrane;","GO:0005337|nucleoside transmembrane transporter activity;GO:0005415|nucleoside:sodium symporter activity;GO:0015213|uridine transmembrane transporter activity;GO:0015293|symporter activity;GO:0015389|pyrimidine- and adenine-specific:sodium symporter activity;GO:0015390|purine-specific nucleoside:sodium symporter activity;","K11536","SLC28A; pyrimidine nucleoside transport protein"]
["ENSRNOG00000002396",24,1.543930516,66,4.261082737,0.362332912,-1.464612238,{"v":5.93498e-06,"d":"5.93E-06"},{"v":4.61491e-06,"d":"4.61E-06"},"down","yes","Serpinb8","protein_coding","chr13:23626945-23650835:+","gi|157786978|ref|NP_001099418.1|",1920,0,"serpin B8 [Rattus norvegicus]","gi|157786977|ref|NM_001105948.1|",2468,0,"Rattus norvegicus serpin peptidase inhibitor, clade B (ovalbumin), member 8 (Serpinb8), mRNA","O08800",681,0,"Serpin B8","MA2246",181,{"v":1e-48,"d":"1.00E-48"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0008150|biological_process;GO:0010951|negative regulation of endopeptidase activity;GO:0090136|epithelial cell-cell adhesion;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0003674|molecular_function;GO:0004867|serine-type endopeptidase inhibitor activity;","K13965","SERPINB8; serpin B8"]
["ENSRNOG00000049150",0,0.032165219,19,1.226675333,0.026221461,-5.253108133,{"v":6.17799e-06,"d":"6.18E-06"},{"v":4.79082e-06,"d":"4.79E-06"},"down","yes","AABR07045621.1","protein_coding","chr20:52127538-52129342:-","gi|148704781|gb|EDL36728.1|",464,{"v":2e-74,"d":"2.00E-74"},"proteasome (prosome, macropain) subunit, alpha type 6, isoform CRA_b, partial [Mus musculus]","gi|57870443|gb|BC089066.1|",1805,0,"Rattus norvegicus hypothetical LOC100125377, mRNA (cDNA clone MGC:105770 IMAGE:7319366), complete cds","Q9QUM9",183,{"v":3e-74,"d":"3.00E-74"},"Proteasome subunit alpha type-6",".",".",".",".","pfam00227","Proteasome","Proteasome subunit. The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria. The second is call beta-proteobacteria proteasome homologue (BPH).","GO:0051603|proteolysis involved in cellular protein catabolic process;","GO:0005634|nucleus;GO:0005839|proteasome core complex;",".",".","."]
["ENSRNOG00000067233",0,0.032165219,19,1.226675333,0.026221461,-5.253108133,{"v":6.17799e-06,"d":"6.18E-06"},{"v":4.79082e-06,"d":"4.79E-06"},"down","yes","ENSRNOG00000067233","IG_V_gene","chr4:98481767-98482496:+","gi|479224|pir||S32806",457,{"v":4e-56,"d":"4.00E-56"},"Ig kappa chain precursor - rat (fragment)","gi|298902151|emb|FQ231614.1|",248,{"v":1E-125,"d":"1.00E-125"},"Rattus norvegicus TL0AEA68YN17 mRNA sequence","A0A075B6S5",159,{"v":2e-49,"d":"2.00E-49"},"Immunoglobulin kappa variable 1-27",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000025581",7,0.450313067,35,2.259665088,0.199283102,-2.327108714,{"v":6.40616e-06,"d":"6.41E-06"},{"v":4.9617e-06,"d":"4.96E-06"},"down","yes","Vwa2","protein_coding","chr1:255923541-255963934:+","gi|672015093|ref|XP_003753476.3|",3974,0,"PREDICTED: von Willebrand factor A domain-containing protein 2 [Rattus norvegicus]","gi|672015092|ref|XM_003753428.3|",4009,0,"PREDICTED: Rattus norvegicus von Willebrand factor A domain containing 2 (Vwa2), mRNA","Q70UZ7",1386,0,"von Willebrand factor A domain-containing protein 2",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0007161|calcium-independent cell-matrix adhesion;GO:0046626|regulation of insulin receptor signaling pathway;","GO:0005576|extracellular region;GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0062023|collagen-containing extracellular matrix;","GO:0005509|calcium ion binding;GO:0042802|identical protein binding;","K24508","VWA2; von Willebrand factor A domain-containing protein 2"]
["ENSRNOG00000048004",7,0.450313067,35,2.259665088,0.199283102,-2.327108714,{"v":6.40616e-06,"d":"6.41E-06"},{"v":4.9617e-06,"d":"4.96E-06"},"down","yes","Garem2","protein_coding","chr6:26230048-26241762:-","gi|300798228|ref|NP_001178803.1|",3267,0,"GRB2-associated and regulator of MAPK protein-like [Rattus norvegicus]","gi|300798227|ref|NM_001191874.1|",2662,0,"Rattus norvegicus GRB2 associated regulator of MAPK1, member 2 (Garem2), mRNA",".",".",".",".",".",".",".",".","pfam12736","CABIT","Cell-cycle sustaining, positive selection,. The 'CABIT' domain (for 'cysteine-containing, all- in Themis') is found in a newly identified gene family that has three mammalian homologues (Themis, Icb1 and 9130404H23Rik) that encode proteins with two CABIT domains and a highly conserved proline-rich region. In contrast, Fam59A, Fam59B and related proteins from mammals to cnidarians, including the insect Serrano proteins, have a single copy of the CABIT domain, a proline-rich region and often a C-terminal SAM (sterile-motif) domain. Multiple-sequence alignment has predicted that the CABIT domain adopts an all-strand structure with at least 12 strands, ie a dyad of six-stranded beta-barrel units. The CABIT domain contains a nearly absolutely conserved cysteine residue which is likely to be central to its function. CABIT domain proteins function downstream of tyrosine kinase signalling and interact with GRB2.",".",".",".",".","."]
["ENSRNOG00000003132",1,0.064330438,20,1.291237193,0.049820775,-4.327108714,{"v":7.29007e-06,"d":"7.29E-06"},{"v":5.61812e-06,"d":"5.62E-06"},"down","yes","Mip","protein_coding","chr7:647315-654400:+","gi|157787095|ref|NP_001099189.1|",1237,{"v":2e-162,"d":"2.00E-162"},"lens fiber major intrinsic protein [Rattus norvegicus]","gi|157787094|ref|NM_001105719.1|",2258,0,"Rattus norvegicus major intrinsic protein of lens fiber (Mip), mRNA","P51180",479,{"v":2e-163,"d":"2.00E-163"},"Lens fiber major intrinsic protein","PA4034",84.3,{"v":4e-17,"d":"4.00E-17"},"COG0580","pfam00230","MIP","Major intrinsic protein. MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.","GO:0002088|lens development in camera-type eye;GO:0006833|water transport;GO:0007601|visual perception;GO:0015722|canalicular bile acid transport;GO:0045785|positive regulation of cell adhesion;GO:0051289|protein homotetramerization;GO:0055085|transmembrane transport;GO:1990349|gap junction-mediated intercellular transport;","GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005921|gap junction;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0046691|intracellular canaliculus;","GO:0005212|structural constituent of eye lens;GO:0005516|calmodulin binding;GO:0015250|water channel activity;","K09863","AQP0, MIP; aquaporin-0"]
["ENSRNOG00000036726",1,0.064330438,20,1.291237193,0.049820775,-4.327108714,{"v":7.29007e-06,"d":"7.29E-06"},{"v":5.61812e-06,"d":"5.62E-06"},"down","yes","Cd300e","protein_coding","chr10:100291437-100299311:-","gi|262205519|ref|NP_001160049.1|",995,{"v":2e-134,"d":"2.00E-134"},"CMRF35-like molecule 2 precursor [Rattus norvegicus]","gi|672069895|ref|XM_008768395.1|",722,0,"PREDICTED: Rattus norvegicus Cd300e molecule (Cd300e), transcript variant X2, mRNA","Q8K249",266,{"v":4e-88,"d":"4.00E-88"},"CMRF35-like molecule 2",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004888|transmembrane signaling receptor activity;","K06719","CD300; CD300 antigen"]
["ENSRNOG00000015105",4,0.257321753,28,1.80773207,0.142345073,-2.812535541,{"v":7.3087E-6,"d":"7.31E-06"},{"v":5.63019E-6,"d":"5.63E-06"},"down","yes","Bspry","protein_coding","chr5:75927405-75949583:+","gi|154354994|ref|NP_071597.2|",1829,0,"B box and SPRY domain-containing protein [Rattus norvegicus]","gi|154354993|ref|NM_022261.2|",2183,0,"Rattus norvegicus B-box and SPRY domain containing (Bspry), mRNA","Q6P6S3",709,0,"B box and SPRY domain-containing protein",".",".",".",".","pfam13765","PRY","SPRY-associated domain. SPRY and PRY domains occur on PYRIN proteins. Their function is not known.","GO:0006816|calcium ion transport;GO:0016567|protein ubiquitination;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0005737|cytoplasm;GO:0016020|membrane;GO:0031252|cell leading edge;GO:0048471|perinuclear region of cytoplasm;","GO:0005515|protein binding;GO:0008270|zinc ion binding;GO:0061630|ubiquitin protein ligase activity;",".","."]
["ENSRNOG00000016368",4,0.257321753,28,1.80773207,0.142345073,-2.812535541,{"v":7.3087E-6,"d":"7.31E-06"},{"v":5.63019E-6,"d":"5.63E-06"},"down","yes","Ppp1r14c","protein_coding","chr1:39773403-39886956:+","gi|19173802|ref|NP_596916.1|",484,{"v":7e-53,"d":"7.00E-53"},"protein phosphatase 1 regulatory subunit 14C [Rattus norvegicus]","gi|118343645|ref|NM_133425.3|",2770,0,"Rattus norvegicus protein phosphatase 1, regulatory (inhibitor) subunit 14c (Ppp1r14c), mRNA","Q8R4R9",191,{"v":2e-54,"d":"2.00E-54"},"Protein phosphatase 1 regulatory subunit 14C",".",".",".",".","pfam05361","PP1_inhibitor","PKC-activated protein phosphatase-1 inhibitor. Contractility of vascular smooth muscle depends on phosphorylation of myosin light chains, and is modulated by hormonal control of myosin phosphatase activity. Signaling pathways activate kinases such as PKC or Rho-dependent kinases that phosphorylate the myosin phosphatase inhibitor protein called CPI-17. Phosphorylation of CPI-17 at Thr-38 enhances its inhibitory potency 1000-fold, creating a molecular switch for regulating contraction.","GO:0042325|regulation of phosphorylation;GO:0043086|negative regulation of catalytic activity;","GO:0005737|cytoplasm;GO:0012505|endomembrane system;GO:0016020|membrane;","GO:0004865|protein serine/threonine phosphatase inhibitor activity;","K17556","PPP1R14C, KEPI; protein phosphatase 1 regulatory subunit 14C"]
["ENSRNOG00000020706",5,0.321652191,30,1.93685579,0.166069251,-2.59014312,{"v":8.87923E-6,"d":"8.88E-06"},{"v":6.7924e-06,"d":"6.79E-06"},"down","yes","Kcnn3","protein_coding","chr2:174936629-175081145:+","gi|149048042|gb|EDM00618.1|",3149,0,"potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3, isoform CRA_a [Rattus norvegicus]","gi|31543038|ref|NM_019315.2|",2485,0,"Rattus norvegicus potassium calcium-activated channel subfamily N member 3 (Kcnn3), mRNA","P70605",1167,0,"Small conductance calcium-activated potassium channel protein 3",".",".",".",".","pfam03530","SK_channel","Calcium-activated SK potassium channel.","GO:0006811|ion transport;GO:0006813|potassium ion transport;GO:0071805|potassium ion transmembrane transport;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030175|filopodium;GO:0031594|neuromuscular junction;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0044297|cell body;","GO:0005242|inward rectifier potassium channel activity;GO:0005516|calmodulin binding;GO:0016286|small conductance calcium-activated potassium channel activity;GO:0044877|protein-containing complex binding;","K04944","KCNN3, KCA2.3; potassium intermediate/small conductance calcium-activated channel subfamily N member 3"]
["ENSRNOG00000027697",5,0.321652191,30,1.93685579,0.166069251,-2.59014312,{"v":8.87923E-6,"d":"8.88E-06"},{"v":6.7924e-06,"d":"6.79E-06"},"down","yes","Nmnat2","protein_coding","chr13:65105950-65278484:+","gi|37359974|dbj|BAC97965.1|",1421,0,"mKIAA0479 protein [Mus musculus]","gi|114158657|ref|NM_001048042.1|",853,0,"Rattus norvegicus nicotinamide nucleotide adenylyltransferase 2 (Nmnat2), mRNA","Q0HA29",504,{"v":4E-176,"d":"4.00E-176"},"Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2","YLR328w_2",100,{"v":5e-23,"d":"5.00E-23"},"COG1057","pfam01467","CTP_transf_2","Cytidylyltransferase. This family includes: Cholinephosphate cytidylyltransferase and Glycerol-3-phosphate cytidylyltransferase.","GO:0007568|aging;GO:0009435|NAD biosynthetic process;GO:1904385|cellular response to angiotensin;","GO:0000139|Golgi membrane;GO:0005737|cytoplasm;GO:0005770|late endosome;GO:0005794|Golgi apparatus;GO:0005802|trans-Golgi network;GO:0005829|cytosol;GO:0030424|axon;GO:0030659|cytoplasmic vesicle membrane;GO:0045202|synapse;","GO:0000309|nicotinamide-nucleotide adenylyltransferase activity;GO:0003674|molecular_function;GO:0004515|nicotinate-nucleotide adenylyltransferase activity;GO:0005524|ATP binding;","K06210","NMNAT; nicotinamide mononucleotide adenylyltransferase [EC:2.7.7.1 2.7.7.18]"]
["ENSRNOG00000023683",21,1.350939202,60,3.873711579,0.348745428,-1.519753792,{"v":9.08422e-06,"d":"9.08E-06"},{"v":6.94549E-6,"d":"6.95E-06"},"down","yes","Nog","protein_coding","chr10:74128712-74130339:-","gi|594655716|ref|XP_007176240.1|",981,{"v":1e-126,"d":"1.00E-126"},"PREDICTED: noggin [Balaenoptera acutorostrata scammoni]","gi|158187530|ref|NM_012990.1|",1628,0,"Rattus norvegicus noggin (Nog), mRNA","P97466",378,{"v":5e-127,"d":"5.00E-127"},"Noggin",".",".",".",".","pfam05806","Noggin","Noggin. This family consists of the eukaryotic Noggin proteins. Noggin is a glycoprotein that binds bone morphogenetic proteins (BMPs) selectively and, when added to osteoblasts, it opposes the effects of BMPs. It has been found that noggin arrests the differentiation of stromal cells, preventing cellular maturation.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001501|skeletal system development;GO:0001503|ossification;GO:0001649|osteoblast differentiation;GO:0001655|urogenital system development;GO:0001657|ureteric bud development;GO:0001701|in utero embryonic development;GO:0001706|endoderm formation;GO:0001707|mesoderm formation;GO:0001837|epithelial to mesenchymal transition;GO:0001839|neural plate morphogenesis;GO:0001843|neural tube closure;GO:0003149|membranous septum morphogenesis;GO:0003151|outflow tract morphogenesis;GO:0003203|endocardial cushion morphogenesis;GO:0003223|ventricular compact myocardium morphogenesis;GO:0007389|pattern specification process;GO:0007411|axon guidance;GO:0007417|central nervous system development;GO:0007420|brain development;GO:0007492|endoderm development;GO:0007613|memory;GO:0008045|motor neuron axon guidance;GO:0008284|positive regulation of cell proliferation;GO:0008542|visual learning;GO:0009953|dorsal/ventral pattern formation;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0021510|spinal cord development;GO:0021533|cell differentiation in hindbrain;GO:0021766|hippocampus development;GO:0021915|neural tube development;GO:0021983|pituitary gland development;GO:0030336|negative regulation of cell migration;GO:0030510|regulation of BMP signaling pathway;GO:0030514|negative regulation of BMP signaling pathway;GO:0030900|forebrain development;GO:0035019|somatic stem cell population maintenance;GO:0042060|wound healing;GO:0042474|middle ear morphogenesis;GO:0042733|embryonic digit morphogenesis;GO:0045668|negative regulation of osteoblast differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048318|axial mesoderm development;GO:0048570|notochord morphogenesis;GO:0048646|anatomical structure formation involved in morphogenesis;GO:0048706|embryonic skeletal system development;GO:0048712|negative regulation of astrocyte differentiation;GO:0048762|mesenchymal cell differentiation;GO:0050679|positive regulation of epithelial cell proliferation;GO:0051216|cartilage development;GO:0055009|atrial cardiac muscle tissue morphogenesis;GO:0060044|negative regulation of cardiac muscle cell proliferation;GO:0060173|limb development;GO:0060272|embryonic skeletal joint morphogenesis;GO:0060302|negative regulation of cytokine activity;GO:0060325|face morphogenesis;GO:0060394|negative regulation of pathway-restricted SMAD protein phosphorylation;GO:0060412|ventricular septum morphogenesis;GO:0060425|lung morphogenesis;GO:0060513|prostatic bud formation;GO:0060676|ureteric bud formation;GO:0060825|fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation;GO:0061037|negative regulation of cartilage development;GO:0061053|somite development;GO:0061312|BMP signaling pathway involved in heart development;GO:0061384|heart trabecula morphogenesis;GO:0061626|pharyngeal arch artery morphogenesis;GO:0070447|positive regulation of oligodendrocyte progenitor proliferation;GO:0071456|cellular response to hypoxia;GO:0071773|cellular response to BMP stimulus;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0090190|positive regulation of branching involved in ureteric bud morphogenesis;GO:0090193|positive regulation of glomerulus development;GO:1905006|negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation;GO:2000313|regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation;GO:2001234|negative regulation of apoptotic signaling pathway;","GO:0005615|extracellular space;GO:0030424|axon;GO:0032991|protein-containing complex;","GO:0005515|protein binding;GO:0019955|cytokine binding;GO:0042803|protein homodimerization activity;GO:0044877|protein-containing complex binding;","K04658","NOG; noggin"]
["ENSRNOG00000001217",31,1.994243584,76,4.906701334,0.406432641,-1.298911822,{"v":9.18919e-06,"d":"9.19E-06"},{"v":7.02199E-6,"d":"7.02E-06"},"down","yes","Lrrc3","protein_coding","chr20:10758955-10762067:+","gi|537239643|gb|ERE86866.1|",1322,{"v":2e-173,"d":"2.00E-173"},"leucine-rich repeat-containing protein 3 [Cricetulus griseus]","gi|564397350|ref|XM_006256240.1|",2037,0,"PREDICTED: Rattus norvegicus leucine rich repeat containing 3 (Lrrc3), transcript variant X1, mRNA","P59035",503,{"v":8e-172,"d":"8.00E-172"},"Leucine-rich repeat-containing protein 3",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.",".","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000031168",33,2.12290446,79,5.100386913,0.4162242,-1.264567248,{"v":9.4747e-06,"d":"9.47E-06"},{"v":7.22952e-06,"d":"7.23E-06"},"down","yes","Arhgap15","protein_coding","chr3:27989633-28600265:+","gi|62078565|ref|NP_001013939.1|",2173,0,"rho GTPase-activating protein 15 [Rattus norvegicus]","gi|62078564|ref|NM_001013917.1|",1306,0,"Rattus norvegicus Rho GTPase activating protein 15 (Arhgap15), mRNA","Q6AYC5",841,0,"Rho GTPase-activating protein 15",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0007165|signal transduction;GO:0008360|regulation of cell shape;GO:0043087|regulation of GTPase activity;","GO:0005737|cytoplasm;GO:0016020|membrane;","GO:0005096|GTPase activator activity;","K20637","ARHGAP15; Rho GTPase-activating protein 15"]
["ENSRNOG00000018764",12,0.771965258,44,2.840721825,0.271749684,-1.879649737,{"v":1.00461E-5,"d":"1.00E-05"},{"v":7.64105e-06,"d":"7.64E-06"},"down","yes","B3gnt3","protein_coding","chr16:18401405-18410766:-","gi|157823527|ref|NP_001099538.1|",1918,0,"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 precursor [Rattus norvegicus]","gi|157823526|ref|NM_001106068.1|",2160,0,"Rattus norvegicus UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 (B3gnt3), mRNA","Q5JCS9",616,0,"N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3",".",".",".",".","pfam01762","Galactosyl_T","Galactosyltransferase. This family includes the galactosyltransferases UDP-galactose:2-acetamido-2-deoxy-D-glucose3beta-galactosyltransferase and UDP-Gal:beta-GlcNAc beta 1,3-galactosyltranferase. Specific galactosyltransferases transfer galactose to GlcNAc terminal chains in the synthesis of the lacto-series oligosaccharides types 1 and 2.","GO:0006486|protein glycosylation;GO:0030311|poly-N-acetyllactosamine biosynthetic process;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0008194|UDP-glycosyltransferase activity;GO:0008532|N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity;GO:0016757|transferase activity, transferring glycosyl groups;","K07970","B3GNT3; beta-1,3-N-acetylglucosaminyltransferase 3 [EC:2.4.1.146 2.4.1.149]"]
["ENSRNOG00000025423",20,1.286608764,58,3.74458786,0.343591554,-1.54123352,{"v":1.04072e-05,"d":"1.04E-05"},{"v":7.90413e-06,"d":"7.90E-06"},"down","yes","Map3k13","protein_coding","chr11:79097247-79235181:-","gi|198386339|ref|NP_001014000.2|",4216,0,"mitogen-activated protein kinase kinase kinase 13 [Rattus norvegicus]","gi|198386338|ref|NM_001013978.2|",3448,0,"Rattus norvegicus mitogen-activated protein kinase kinase kinase 13 (Map3k13), mRNA","Q1HKZ5",1558,0,"Mitogen-activated protein kinase kinase kinase 13",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0006468|protein phosphorylation;GO:0007254|JNK cascade;GO:0014042|positive regulation of neuron maturation;GO:0018105|peptidyl-serine phosphorylation;GO:0043507|positive regulation of JUN kinase activity;GO:0045773|positive regulation of axon extension;GO:0045860|positive regulation of protein kinase activity;GO:0046777|protein autophosphorylation;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051403|stress-activated MAPK cascade;GO:0150012|positive regulation of neuron projection arborization;GO:1905492|positive regulation of branching morphogenesis of a nerve;","GO:0005737|cytoplasm;GO:0016020|membrane;","GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0004706|JUN kinase kinase kinase activity;GO:0004709|MAP kinase kinase kinase activity;GO:0005524|ATP binding;GO:0019899|enzyme binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0106137|IkappaB kinase complex binding;","K04422","MAP3K13, LZK; mitogen-activated protein kinase kinase kinase 13 [EC:2.7.11.25]"]
["ENSRNOG00000004994",0,0.032165219,18,1.162113474,0.027678209,-5.175105621,{"v":1.11644e-05,"d":"1.12E-05"},{"v":8.44434e-06,"d":"8.44E-06"},"down","yes","Agr3","protein_coding","chr6:52643391-52666638:+","gi|148704912|gb|EDL36859.1|",880,{"v":2e-115,"d":"2.00E-115"},"RIKEN cDNA E030025L21, partial [Mus musculus]","gi|157822098|ref|NM_001106724.1|",1069,0,"Rattus norvegicus anterior gradient 3, protein disulphide isomerase family member (Agr3), mRNA","Q8R3W7",320,{"v":3e-108,"d":"3.00E-108"},"Anterior gradient protein 3",".",".",".",".","pfam13899","Thioredoxin_7","Thioredoxin-like. Thioredoxins are small enzymes that participate in redox reactions, via the reversible oxidation of an active centre disulfide bond.","GO:0060548|negative regulation of cell death;","GO:0005783|endoplasmic reticulum;GO:0043231|intracellular membrane-bounded organelle;","GO:0002162|dystroglycan binding;","K20357","AGR3; anterior gradient protein 3"]
["ENSRNOG00000023389",0,0.032165219,18,1.162113474,0.027678209,-5.175105621,{"v":1.11644e-05,"d":"1.12E-05"},{"v":8.44434e-06,"d":"8.44E-06"},"down","yes","Ephx4","protein_coding","chr14:2340248-2373022:-","gi|564382526|ref|XP_006250603.1|",1838,0,"PREDICTED: epoxide hydrolase 4 isoform X1 [Rattus norvegicus]","gi|564382525|ref|XM_006250541.1|",1233,0,"PREDICTED: Rattus norvegicus epoxide hydrolase 4 (Ephx4), transcript variant X1, mRNA","Q6IE26",704,0,"Epoxide hydrolase 4",".",".",".",".","pfam12697","Abhydrolase_6","Alpha/beta hydrolase family. This family contains alpha/beta hydrolase enzymes of diverse specificity.",".",".","GO:0016787|hydrolase activity;","K22369","EPHX4; epoxide hydrolase 4 [EC:3.3.-.-]"]
["ENSRNOG00000031785",0,0.032165219,18,1.162113474,0.027678209,-5.175105621,{"v":1.11644e-05,"d":"1.12E-05"},{"v":8.44434e-06,"d":"8.44E-06"},"down","yes","Krt76","protein_coding","chr7:133016992-133025496:-","gi|57012372|ref|NP_001008805.1|",1996,0,"keratin, type II cytoskeletal 2 oral [Rattus norvegicus]","gi|57012371|ref|NM_001008805.1|",1746,0,"Rattus norvegicus keratin 76, type II (Krt76), mRNA","Q3UV17",674,0,"Keratin, type II cytoskeletal 2 oral",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0007010|cytoskeleton organization;GO:0008544|epidermis development;GO:0043473|pigmentation;GO:0045103|intermediate filament-based process;GO:0048733|sebaceous gland development;","GO:0005882|intermediate filament;GO:0045095|keratin filament;","GO:0005200|structural constituent of cytoskeleton;","K07605","KRT2; type II keratin, basic"]
["ENSRNOG00000063895",0,0.032165219,18,1.162113474,0.027678209,-5.175105621,{"v":1.11644e-05,"d":"1.12E-05"},{"v":8.44434e-06,"d":"8.44E-06"},"down","yes","ENSRNOG00000063895","lncRNA","chr14:104865618-104870059:+",".",".",".",".","gi|77157707|gb|AC159092.11|",580,0,"Mus musculus chromosome 1, clone RP23-103C13, complete sequence",".",".",".",".",".",".",".",".","pfam15188","CCDC-167","Coiled-coil domain-containing protein 167. The function of this family of coiled-coil domains, has not, as yet, been determined. Members of this family remain uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between and 103 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000064657",0,0.032165219,18,1.162113474,0.027678209,-5.175105621,{"v":1.11644e-05,"d":"1.12E-05"},{"v":8.44434e-06,"d":"8.44E-06"},"down","yes","ENSRNOG00000064657","protein_coding","chr4:98863552-98864056:-","gi|204831|gb|AAA41416.1|",566,{"v":2e-72,"d":"2.00E-72"},"immunoglobulin kappa-chain, partial [Rattus norvegicus]","gi|204830|gb|L07408.1|RATIGKVCL",349,0,"Rattus norvegicus (hybridoma 56R-3) immunoglobulin rearranged kappa-chain mRNA variable (V) region, partial cds","P01635",144,{"v":3E-43,"d":"3.00E-43"},"Ig kappa chain V-V region K2 (Fragment)",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000004483",25,1.608260955,66,4.261082737,0.377430117,-1.405718549,{"v":1.1274e-05,"d":"1.13E-05"},{"v":8.52047e-06,"d":"8.52E-06"},"down","yes","Ptprr","protein_coding","chr7:51662595-51929603:+","gi|164607158|ref|NP_446046.2|",3446,0,"receptor-type tyrosine-protein phosphatase R isoform 1 precursor [Rattus norvegicus]","gi|164607157|ref|NM_053594.2|",3561,0,"Rattus norvegicus protein tyrosine phosphatase, receptor type, R (Ptprr), transcript variant 1, mRNA","O08617",1325,0,"Receptor-type tyrosine-protein phosphatase R","SPAC11E3.09",122,{"v":8e-29,"d":"8.00E-29"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0001701|in utero embryonic development;GO:0006470|protein dephosphorylation;GO:0007399|nervous system development;GO:0010633|negative regulation of epithelial cell migration;GO:0030182|neuron differentiation;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0038128|ERBB2 signaling pathway;GO:0070373|negative regulation of ERK1 and ERK2 cascade;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030054|cell junction;","GO:0004725|protein tyrosine phosphatase activity;GO:0005515|protein binding;GO:0019901|protein kinase binding;","K04458","PTPRR; receptor-type tyrosine-protein phosphatase R [EC:3.1.3.48]"]
["ENSRNOG00000011599",9,0.578973944,38,2.453350667,0.235993147,-2.083183131,{"v":1.12927e-05,"d":"1.13E-05"},{"v":8.53236e-06,"d":"8.53E-06"},"down","yes","Gldc","protein_coding","chr1:227883249-227962097:-","gi|564333275|ref|XP_006231272.1|",4512,0,"PREDICTED: glycine dehydrogenase (decarboxylating), mitochondrial isoform X1 [Rattus norvegicus]","gi|672040077|ref|XM_006231210.2|",3107,0,"PREDICTED: Rattus norvegicus glycine dehydrogenase (decarboxylating) (Gldc), transcript variant X1, mRNA","Q91W43",1691,0,"Glycine dehydrogenase (decarboxylating), mitochondrial","all4607_2",658,0,"COG1003","pfam02347","GDC-P","Glycine cleavage system P-protein. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is:- Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2","GO:0006546|glycine catabolic process;GO:0019464|glycine decarboxylation via glycine cleavage system;GO:0065003|protein-containing complex assembly;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0005654|nucleoplasm;GO:0005739|mitochondrion;GO:0005886|plasma membrane;GO:0005960|glycine cleavage complex;","GO:0004375|glycine dehydrogenase (decarboxylating) activity;GO:0016594|glycine binding;GO:0016829|lyase activity;GO:0019899|enzyme binding;GO:0030170|pyridoxal phosphate binding;","K00281","GLDC, gcvP; glycine dehydrogenase [EC:1.4.4.2]"]
["ENSRNOG00000069871",27,1.736921831,69,4.454768316,0.389901721,-1.358817574,{"v":1.21165E-5,"d":"1.21E-05"},{"v":9.13305e-06,"d":"9.13E-06"},"down","yes","ENSRNOG00000069871","lncRNA","chr19:34044546-34046564:+","gi|148677539|gb|EDL09486.1|",289,{"v":4e-27,"d":"4.00E-27"},"mCG147332 [Mus musculus]","gi|354799633|gb|JN964134.1|",397,0,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Pla2g15:tm1e(EUCOMM)Hmgu; transgenic","Q05860",56.2,1e-06,"Formin-1",".",".",".",".","pfam04986","Y2_Tnp","Putative transposase. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases IS1294 and IS801. This is a rolling-circle transposase.",".",".",".",".","."]
["ENSRNOG00000009505",2,0.128660876,22,1.420360912,0.090583228,-3.464612238,{"v":1.22273e-05,"d":"1.22E-05"},{"v":9.21046e-06,"d":"9.21E-06"},"down","yes","Cd164l2","protein_coding","chr5:145423892-145427720:+","gi|564353138|ref|XP_006239054.1|",688,{"v":6e-88,"d":"6.00E-88"},"PREDICTED: CD164 sialomucin-like 2 protein isoform X1 [Rattus norvegicus]","gi|404247436|ref|NM_001271259.1|",854,0,"Rattus norvegicus CD164 molecule like 2 (Cd164l2), mRNA","Q9D6W7",250,{"v":1e-81,"d":"1.00E-81"},"CD164 sialomucin-like 2 protein",".",".",".",".","pfam05283","MGC-24","Multi-glycosylated core protein 24 (MGC-24). This family consists of several MGC-24 (or Cd164 antigen) proteins from eukaryotic organisms. MGC-24/CD164 is a sialomucin expressed in many normal and cancerous tissues. In humans, soluble and transmembrane forms of MGC-24 are produced by alternative splicing.",".","GO:0016021|integral component of membrane;GO:0031410|cytoplasmic vesicle;",".",".","."]
["ENSRNOG00000043150",4,0.257321753,27,1.743170211,0.147617112,-2.760068122,{"v":1.29466e-05,"d":"1.29E-05"},{"v":9.73176e-06,"d":"9.73E-06"},"down","yes","Arfgap1","protein_coding","chr3:168084614-168099933:+","gi|148675420|gb|EDL07367.1|",1799,0,"ADP-ribosylation factor GTPase activating protein 1, isoform CRA_c, partial [Mus musculus]","gi|672047974|ref|XM_006235733.2|",3019,0,"PREDICTED: Rattus norvegicus ADP-ribosylation factor GTPase activating protein 1 (Arfgap1), transcript variant X3, mRNA","Q62848",645,0,"ADP-ribosylation factor GTPase-activating protein 1","YDL226c",123,{"v":3e-29,"d":"3.00E-29"},"COG5347","pfam01412","ArfGap","Putative GTPase activating protein for Arf. Putative zinc fingers with GTPase activating proteins (GAPs) towards the small GTPase, Arf. The GAP of ARD1 stimulates GTPase hydrolysis for ARD1 but not ARFs.","GO:0015031|protein transport;GO:0016192|vesicle-mediated transport;GO:0030100|regulation of endocytosis;GO:0032012|regulation of ARF protein signal transduction;GO:0050790|regulation of catalytic activity;","GO:0000139|Golgi membrane;GO:0014069|postsynaptic density;GO:0045202|synapse;","GO:0005096|GTPase activator activity;GO:0005515|protein binding;GO:0046872|metal ion binding;","K12492","ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1"]
["ENSRNOG00000070878",4,0.257321753,27,1.743170211,0.147617112,-2.760068122,{"v":1.29466e-05,"d":"1.29E-05"},{"v":9.73176e-06,"d":"9.73E-06"},"down","yes","ENSRNOG00000070878","protein_coding","chr5:110908577-110913310:-","gi|16741207|gb|AAH16446.1|",686,{"v":1e-86,"d":"1.00E-86"},"Cyp2j13 protein [Mus musculus]","gi|755507997|ref|XM_006502937.2|",335,{"v":7e-174,"d":"7.00E-174"},"PREDICTED: Mus musculus cytochrome P450, family 2, subfamily j, polypeptide 13 (Cyp2j13), transcript variant X2, mRNA","P51590",204,{"v":6e-62,"d":"6.00E-62"},"Cytochrome P450 2J3","BH0579",61.6,{"v":6E-11,"d":"6.00E-11"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.",".",".",".",".","."]
["ENSRNOG00000066332",1,0.064330438,19,1.226675333,0.052442921,-4.253108133,{"v":1.34798e-05,"d":"1.35E-05"},{"v":1.01179E-5,"d":"1.01E-05"},"down","yes","ENSRNOG00000066332","protein_coding","chr17:45117812-45180027:+","gi|149029254|gb|EDL84521.1|",1389,{"v":2E-180,"d":"2.00E-180"},"rCG23113, isoform CRA_a [Rattus norvegicus]","gi|755544276|ref|XM_006516705.2|",1606,0,"PREDICTED: Mus musculus G protein-coupled receptor 141 (Gpr141), transcript variant X7, mRNA","Q7TQP0",510,{"v":1e-170,"d":"1.00E-170"},"Probable G-protein coupled receptor 141",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.",".",".",".",".","."]
["ENSRNOG00000068727",1,0.064330438,19,1.226675333,0.052442921,-4.253108133,{"v":1.34798e-05,"d":"1.35E-05"},{"v":1.01179E-5,"d":"1.01E-05"},"down","yes","ENSRNOG00000068727","lncRNA","chr19:16175822-16177101:+","gi|149032669|gb|EDL87539.1|",213,{"v":4e-18,"d":"4.00E-18"},"rCG63141 [Rattus norvegicus]","gi|46275997|gb|AC138792.2|",784,0,"Mus musculus BAC clone RP23-235I2 from chromosome 8, complete sequence",".",".",".",".",".",".",".",".","pfam14883","GHL13","Hypothetical glycosyl hydrolase family 13. GHL13 is a family of hypothetical glycoside hydrolases.",".",".",".",".","."]
["ENSRNOG00000069321",26,1.672591393,67,4.325644597,0.386668705,-1.370830092,{"v":1.42047E-5,"d":"1.42E-05"},{"v":1.06411E-5,"d":"1.06E-05"},"down","yes","Ttc30a","protein_coding","chr3:60901896-60905350:-","gi|407339769|ref|NP_001258423.1|",3473,0,"tetratricopeptide repeat domain 30B [Rattus norvegicus]","gi|407339768|ref|NM_001271494.1|",3455,0,"Rattus norvegicus tetratricopeptide repeat domain 30A (Ttc30a), mRNA","Q99J38",1313,0,"Tetratricopeptide repeat protein 30A1",".",".",".",".","pfam13414","TPR_11","TPR repeat.",".",".",".",".","."]
["ENSRNOG00000012546",13,0.836295696,45,2.905283684,0.287853369,-1.796593998,{"v":1.4869e-05,"d":"1.49E-05"},{"v":1.113E-5,"d":"1.11E-05"},"down","yes","Frmpd1","protein_coding","chr5:59443076-59545080:+","gi|564305255|ref|XP_006225341.1|",7705,0,"PREDICTED: FERM and PDZ domain-containing protein 1 [Rattus norvegicus]","gi|672019285|ref|XM_006225280.2|",4779,0,"PREDICTED: Rattus norvegicus FERM and PDZ domain containing 1 (Frmpd1), transcript variant X2, mRNA","A2AKB4",2631,0,"FERM and PDZ domain-containing protein 1",".",".",".",".","pfam00373","FERM_M","FERM central domain. This domain is the central structural domain of the FERM domain.","GO:0007165|signal transduction;GO:0008150|biological_process;GO:0008277|regulation of G protein-coupled receptor signaling pathway;GO:0090150|establishment of protein localization to membrane;","GO:0005575|cellular_component;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0005938|cell cortex;GO:0032991|protein-containing complex;","GO:0005515|protein binding;","K23954","FRMPD1; FERM and PDZ domain-containing protein 1"]
["ENSRNOG00000029514",5,0.321652191,29,1.87229393,0.171795777,-2.54123352,{"v":1.54532E-5,"d":"1.55E-05"},{"v":1.15551e-05,"d":"1.16E-05"},"down","yes","Slc26a9","protein_coding","chr13:43177867-43204330:+","gi|157820907|ref|NP_001100642.1|",4166,0,"solute carrier family 26 member 9 [Rattus norvegicus]","gi|157820906|ref|NM_001107172.1|",3580,0,"Rattus norvegicus solute carrier family 26 member 9 (Slc26a9), mRNA","Q8BU91",1536,0,"Solute carrier family 26 member 9","Cgl1025",148,{"v":4e-36,"d":"4.00E-36"},"COG0659","pfam00916","Sulfate_transp","Sulfate transporter family. Mutations in human SLC26A2 lead to several human diseases.","GO:0006820|anion transport;GO:0006821|chloride transport;GO:0006885|regulation of pH;GO:0010628|positive regulation of gene expression;GO:0015701|bicarbonate transport;GO:0019532|oxalate transport;GO:1902358|sulfate transmembrane transport;GO:1902476|chloride transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0016324|apical plasma membrane;","GO:0005254|chloride channel activity;GO:0008271|secondary active sulfate transmembrane transporter activity;GO:0015106|bicarbonate transmembrane transporter activity;GO:0015108|chloride transmembrane transporter activity;GO:0015116|sulfate transmembrane transporter activity;GO:0015301|anion:anion antiporter activity;GO:0019531|oxalate transmembrane transporter activity;GO:0051117|ATPase binding;","K14706","SLC26A9; solute carrier family 26 (sulfate anion transporter), member 9"]
["ENSRNOG00000059225",5,0.321652191,29,1.87229393,0.171795777,-2.54123352,{"v":1.54532E-5,"d":"1.55E-05"},{"v":1.15551e-05,"d":"1.16E-05"},"down","yes","AABR07020987.1","lncRNA","chr13:45420329-45430345:+",".",".",".",".","gi|88023528|gb|AC121223.5|",272,{"v":3e-138,"d":"3.00E-138"},"Rattus norvegicus BAC CH230-70M4 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam14967","FAM70","FAM70 protein. This family of proteins is found in eukaryotes. Proteins in this family are typically between 241 and 349 amino acids in length. The function of this family is unknown.",".",".",".",".","."]
["ENSRNOG00000026286",32,2.058574022,76,4.906701334,0.419543372,-1.253108133,{"v":1.60971e-05,"d":"1.61E-05"},{"v":1.20209E-5,"d":"1.20E-05"},"down","yes","Nhlrc1","protein_coding","chr17:17674319-17677148:+","gi|40385887|ref|NP_954706.1|",1791,0,"E3 ubiquitin-protein ligase NHLRC1 [Rattus norvegicus]","gi|34849941|gb|AC133492.10|",2830,0,"Rattus norvegicus clone rp32-478o16, complete sequence","Q6IMG5",694,0,"E3 ubiquitin-protein ligase NHLRC1",".",".",".",".","pfam13920","zf-C3HC4_3","Zinc finger, C3HC4 type (RING finger).","GO:0000209|protein polyubiquitination;GO:0001932|regulation of protein phosphorylation;GO:0005977|glycogen metabolic process;GO:0005978|glycogen biosynthetic process;GO:0006914|autophagy;GO:0010468|regulation of gene expression;GO:0031396|regulation of protein ubiquitination;GO:0031398|positive regulation of protein ubiquitination;GO:0034976|response to endoplasmic reticulum stress;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0044260|cellular macromolecule metabolic process;GO:0045859|regulation of protein kinase activity;GO:1903076|regulation of protein localization to plasma membrane;","GO:0005634|nucleus;GO:0005783|endoplasmic reticulum;GO:0048471|perinuclear region of cytoplasm;","GO:0004842|ubiquitin-protein transferase activity;GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;","K10602","NHLRC1; E3 ubiquitin-protein ligase NHLRC1 [EC:2.3.2.27]"]
["ENSRNOG00000019692",38,2.444556651,85,5.487758071,0.445456345,-1.166644042,{"v":1.62718e-05,"d":"1.63E-05"},{"v":1.21497E-5,"d":"1.21E-05"},"down","yes","Metrn","protein_coding","chr10:14816572-14818701:-","gi|58000409|ref|NP_001009962.1|",1309,{"v":5e-179,"d":"5.00E-179"},"meteorin precursor [Rattus norvegicus]","gi|58000408|ref|NM_001009962.1|",920,0,"Rattus norvegicus meteorin, glial cell differentiation regulator (Metrn), mRNA","Q5Q0T9",508,{"v":2E-180,"d":"2.00E-180"},"Meteorin",".",".",".",".","pfam15324","TALPID3","Hedgehog signalling target. TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.","GO:0007165|signal transduction;GO:0010001|glial cell differentiation;GO:0050772|positive regulation of axonogenesis;","GO:0005615|extracellular space;","GO:0005179|hormone activity;",".","."]
["ENSRNOG00000006588",9,0.578973944,37,2.388788807,0.24237134,-2.044708984,{"v":1.85986e-05,"d":"1.86E-05"},{"v":1.38202E-5,"d":"1.38E-05"},"down","yes","Meox2","protein_coding","chr6:53856758-53917467:+","gi|795154920|ref|XP_011839342.1|",1163,{"v":1E-150,"d":"1.00E-150"},"PREDICTED: homeobox protein MOX-2 isoform X1 [Mandrillus leucophaeus]","gi|8393772|ref|NM_017149.1|",2201,0,"Rattus norvegicus mesenchyme homeobox 2 (Meox2), mRNA","P32443",447,{"v":2E-150,"d":"2.00E-150"},"Homeobox protein MOX-2",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0001525|angiogenesis;GO:0001757|somite specification;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007519|skeletal muscle tissue development;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0060021|roof of mouth development;GO:0060173|limb development;GO:0061053|somite development;GO:0090051|negative regulation of cell migration involved in sprouting angiogenesis;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0016607|nuclear speck;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09322","MEOX, MOX; homeobox protein MOX"]
["ENSRNOG00000030253",15,0.964956573,48,3.098969263,0.311379846,-1.683252524,{"v":1.92344E-5,"d":"1.92E-05"},{"v":1.42723e-05,"d":"1.43E-05"},"down","yes","Tafa3","protein_coding","chr2:192267093-192274019:-","gi|564300804|ref|XP_006224296.1|",679,{"v":1e-81,"d":"1.00E-81"},"PREDICTED: protein FAM19A3 [Rattus norvegicus]","gi|672016182|ref|XM_006224235.2|",2176,0,"PREDICTED: Rattus norvegicus family with sequence similarity 19 (chemokine (C-C motif)-like), member A3 (Fam19a3), transcript variant X2, mRNA","Q7TPG6",246,{"v":8e-76,"d":"8.00E-76"},"Protein FAM19A3",".",".",".",".","pfam12020","TAFA","TAFA family. This family of secreted proteins are brain specific and thought to be chemokines. These proteins are found in vertebrates. Proteins in this family are typically between 94 to 133 amino acids in length and contain a number of conserved cysteines.","GO:0007165|signal transduction;GO:0014016|neuroblast differentiation;GO:1902692|regulation of neuroblast proliferation;GO:1903979|negative regulation of microglial cell activation;GO:1903980|positive regulation of microglial cell activation;","GO:0005615|extracellular space;","GO:0048018|receptor ligand activity;","K25542","TAFA2_3, FAM19A2_3; chemokine-like protein TAFA2/3"]
["ENSRNOG00000051418",0,0.032165219,17,1.097551614,0.029306338,-5.092643461,{"v":2.02646e-05,"d":"2.03E-05"},{"v":1.49997E-5,"d":"1.50E-05"},"down","yes","RGD1310935","protein_coding","chr11:43483519-43526916:+","gi|672025977|ref|XP_008774799.1|",1522,0,"PREDICTED: transmembrane protein 45A [Rattus norvegicus]","gi|672025976|ref|XM_008776577.1|",1217,0,"PREDICTED: Rattus norvegicus similar to Dermal papilla derived protein 7 (RGD1310935), transcript variant X1, mRNA","Q9NWC5",254,{"v":4e-80,"d":"4.00E-80"},"Transmembrane protein 45A",".",".",".",".","pfam04819","DUF716","Family of unknown function (DUF716). This family is equally distributed in both metazoa and plants. Annotation associated with a member from Nicotiana tabacum suggest that it may be involved in response to viral attack in plants. However, no clear function has been assigned to this family.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000063669",0,0.032165219,17,1.097551614,0.029306338,-5.092643461,{"v":2.02646e-05,"d":"2.03E-05"},{"v":1.49997E-5,"d":"1.50E-05"},"down","yes","Stfa2l2","protein_coding","chr11:64498206-64500574:+","gi|564314487|ref|XP_006221214.1|",543,{"v":5e-69,"d":"5.00E-69"},"PREDICTED: stefin-2-like isoform X2 [Rattus norvegicus]","gi|672026106|ref|XM_006221152.2|",400,0,"PREDICTED: Rattus norvegicus stefin A2-like 3 (Stfa2l3), transcript variant X2, mRNA","P35174",162,{"v":2E-50,"d":"2.00E-50"},"Stefin-2",".",".",".",".","pfam00031","Cystatin","Cystatin domain. Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 are related to this family but have not been included.",".",".",".",".","."]
["ENSRNOG00000063715",40,2.573217527,87,5.61688179,0.458122073,-1.12619602,{"v":2.23962e-05,"d":"2.24E-05"},{"v":1.65175e-05,"d":"1.65E-05"},"down","yes","ENSRNOG00000063715","protein_coding","chr1:134302925-134304766:-","gi|148666118|gb|EDK98534.1|",574,{"v":2e-67,"d":"2.00E-67"},"mCG128032, partial [Mus musculus]","gi|672026468|ref|XR_590008.1|",392,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103690996 (LOC103690996), ncRNA","P04646",223,{"v":2e-68,"d":"2.00E-68"},"60S ribosomal protein L35a","YOR234c",107,{"v":2e-26,"d":"2.00E-26"},"COG2451","pfam01247","Ribosomal_L35Ae","Ribosomal protein L35Ae.",".",".",".",".","."]
["ENSRNOG00000001924",4,0.257321753,26,1.678608351,0.153294694,-2.705620337,{"v":2.28723e-05,"d":"2.29E-05"},{"v":1.68578E-5,"d":"1.69E-05"},"down","yes","Tp63","protein_coding","chr11:74838859-75049398:-","gi|9507209|ref|NP_062094.1|",3525,0,"tumor protein 63 isoform a [Rattus norvegicus]","gi|189083852|ref|NM_019221.3|",4960,0,"Rattus norvegicus tumor protein p63 (Tp63), transcript variant 1, mRNA","Q9JJP6",1360,0,"Tumor protein 63",".",".",".",".","pfam00870","P53","P53 DNA-binding domain. This family contains one anomalous member, viz: Zea mays (Q6JAD8). This sequence is identical to human P53 and would appear to be a a human contaminant within the Zea mays sampling effort.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001501|skeletal system development;GO:0001736|establishment of planar polarity;GO:0001738|morphogenesis of a polarized epithelium;GO:0001942|hair follicle development;GO:0002053|positive regulation of mesenchymal cell proliferation;GO:0002064|epithelial cell development;GO:0006338|chromatin remodeling;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006974|cellular response to DNA damage stimulus;GO:0007219|Notch signaling pathway;GO:0007283|spermatogenesis;GO:0007389|pattern specification process;GO:0007499|ectoderm and mesoderm interaction;GO:0007568|aging;GO:0007569|cell aging;GO:0008283|cell proliferation;GO:0008284|positive regulation of cell proliferation;GO:0008544|epidermis development;GO:0009887|animal organ morphogenesis;GO:0009913|epidermal cell differentiation;GO:0009954|proximal/distal pattern formation;GO:0010259|multicellular organism aging;GO:0010481|epidermal cell division;GO:0010482|regulation of epidermal cell division;GO:0010838|positive regulation of keratinocyte proliferation;GO:0030154|cell differentiation;GO:0030216|keratinocyte differentiation;GO:0030326|embryonic limb morphogenesis;GO:0030850|prostate gland development;GO:0030855|epithelial cell differentiation;GO:0030859|polarized epithelial cell differentiation;GO:0031069|hair follicle morphogenesis;GO:0033147|negative regulation of intracellular estrogen receptor signaling pathway;GO:0035115|embryonic forelimb morphogenesis;GO:0035116|embryonic hindlimb morphogenesis;GO:0036342|post-anal tail morphogenesis;GO:0042475|odontogenesis of dentin-containing tooth;GO:0042771|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0043066|negative regulation of apoptotic process;GO:0043281|regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043589|skin morphogenesis;GO:0043616|keratinocyte proliferation;GO:0045617|negative regulation of keratinocyte differentiation;GO:0045669|positive regulation of osteoblast differentiation;GO:0045747|positive regulation of Notch signaling pathway;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048485|sympathetic nervous system development;GO:0048646|anatomical structure formation involved in morphogenesis;GO:0048745|smooth muscle tissue development;GO:0048807|female genitalia morphogenesis;GO:0051262|protein tetramerization;GO:0051402|neuron apoptotic process;GO:0060157|urinary bladder development;GO:0060197|cloacal septation;GO:0060513|prostatic bud formation;GO:0060529|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development;GO:0061436|establishment of skin barrier;GO:0098773|skin epidermis development;GO:1902808|positive regulation of cell cycle G1/S phase transition;GO:1904674|positive regulation of somatic stem cell population maintenance;GO:1904888|cranial skeletal system development;GO:2000271|positive regulation of fibroblast apoptotic process;GO:2000381|negative regulation of mesoderm development;GO:2000773|negative regulation of cellular senescence;GO:2001235|positive regulation of apoptotic signaling pathway;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005791|rough endoplasmic reticulum;GO:0030425|dendrite;GO:0032991|protein-containing complex;GO:0043005|neuron projection;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0002039|p53 binding;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003684|damaged DNA binding;GO:0003690|double-stranded DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0019904|protein domain specific binding;GO:0042802|identical protein binding;GO:0043565|sequence-specific DNA binding;GO:0046872|metal ion binding;GO:0050699|WW domain binding;GO:0097371|MDM2/MDM4 family protein binding;","K10149","TP63; tumor protein p63"]
["ENSRNOG00000006957",25,1.608260955,64,4.131959018,0.389224808,-1.36132443,{"v":2.44402E-5,"d":"2.44E-05"},{"v":1.79762e-05,"d":"1.80E-05"},"down","yes","Gria4","protein_coding","chr8:1562119-2034979:-","gi|940757567|ref|XP_006098893.2|",4726,0,"PREDICTED: glutamate receptor 4 isoform X1 [Myotis lucifugus]","gi|164419760|ref|NM_017263.2|",4124,0,"Rattus norvegicus glutamate ionotropic receptor AMPA type subunit 4 (Gria4), transcript variant 1, mRNA","Q9Z2W8",1813,0,"Glutamate receptor 4","YPO1846",54.3,7e-07,"COG0834","pfam00060","Lig_chan","Ligand-gated ion channel. This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.","GO:0007268|chemical synaptic transmission;GO:0034220|ion transmembrane transport;GO:0035235|ionotropic glutamate receptor signaling pathway;GO:0050803|regulation of synapse structure or activity;GO:0050804|modulation of chemical synaptic transmission;GO:0051968|positive regulation of synaptic transmission, glutamatergic;GO:0060078|regulation of postsynaptic membrane potential;GO:0060992|response to fungicide;","GO:0005886|plasma membrane;GO:0008328|ionotropic glutamate receptor complex;GO:0014069|postsynaptic density;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0032281|AMPA glutamate receptor complex;GO:0032983|kainate selective glutamate receptor complex;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0043197|dendritic spine;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0098978|glutamatergic synapse;GO:0099061|integral component of postsynaptic density membrane;","GO:0004970|ionotropic glutamate receptor activity;GO:0004971|AMPA glutamate receptor activity;GO:0005515|protein binding;GO:0015276|ligand-gated ion channel activity;GO:0038023|signaling receptor activity;GO:0042802|identical protein binding;GO:1904315|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K05200","GRIA4; glutamate receptor 4"]
["ENSRNOG00000042140",1,0.064330438,18,1.162113474,0.055356417,-4.175105621,{"v":2.4979e-05,"d":"2.50E-05"},{"v":1.83489E-5,"d":"1.83E-05"},"down","yes","Eomes","protein_coding","chr8:118181777-118188316:+","gi|148677303|gb|EDL09250.1|",2908,0,"eomesodermin homolog (Xenopus laevis), isoform CRA_a, partial [Mus musculus]","gi|258645097|ref|NM_010136.3|",1903,0,"Mus musculus eomesodermin (Eomes), transcript variant 1, mRNA","O54839",1102,0,"Eomesodermin homolog",".",".",".",".","pfam00907","T-box","T-box. The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001706|endoderm formation;GO:0001707|mesoderm formation;GO:0001714|endodermal cell fate specification;GO:0001824|blastocyst development;GO:0001829|trophectodermal cell differentiation;GO:0002302|CD8-positive, alpha-beta T cell differentiation involved in immune response;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007420|brain development;GO:0007492|endoderm development;GO:0009653|anatomical structure morphogenesis;GO:0010002|cardioblast differentiation;GO:0010468|regulation of gene expression;GO:0019827|stem cell population maintenance;GO:0021772|olfactory bulb development;GO:0021796|cerebral cortex regionalization;GO:0021895|cerebral cortex neuron differentiation;GO:0022008|neurogenesis;GO:0030154|cell differentiation;GO:0030182|neuron differentiation;GO:0035914|skeletal muscle cell differentiation;GO:0043433|negative regulation of DNA-binding transcription factor activity;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048382|mesendoderm development;GO:0060706|cell differentiation involved in embryonic placenta development;GO:0060809|mesodermal to mesenchymal transition involved in gastrulation;","GO:0000785|chromatin;GO:0005634|nucleus;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0003682|chromatin binding;GO:0043565|sequence-specific DNA binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;GO:1990837|sequence-specific double-stranded DNA binding;","K10173","EOMES, TBR2; eomesodermin protein"]
["ENSRNOG00000056654",22,1.41526964,59,3.80914972,0.371544766,-1.42839205,{"v":2.64326e-05,"d":"2.64E-05"},{"v":1.93867e-05,"d":"1.94E-05"},"down","yes","Dnaaf4","protein_coding","chr8:73698103-73711292:+","gi|55742717|ref|NP_001007011.1|",2011,0,"dyslexia susceptibility 1 candidate gene 1 protein homolog [Rattus norvegicus]","gi|55742716|ref|NM_001007010.1|",1992,0,"Rattus norvegicus dyslexia susceptibility 1 candidate 1 (Dyx1c1), mRNA","Q5VJS5",779,0,"Dynein assembly factor 4, axonemal","FN1787",58.5,5e-08,"COG0457","pfam13414","TPR_11","TPR repeat.","GO:0001764|neuron migration;GO:0003341|cilium movement;GO:0003351|epithelial cilium movement;GO:0007368|determination of left/right symmetry;GO:0007507|heart development;GO:0007611|learning or memory;GO:0033146|regulation of intracellular estrogen receptor signaling pathway;GO:0036158|outer dynein arm assembly;GO:0036159|inner dynein arm assembly;GO:0061136|regulation of proteasomal protein catabolic process;","GO:0005576|extracellular region;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0043005|neuron projection;GO:0097730|non-motile cilium;","GO:0005515|protein binding;GO:0030331|estrogen receptor binding;","K19758","DNAAF4, DYX1C1; dynein axonemal assembly factor 4"]
["ENSRNOG00000015089",5,0.321652191,28,1.80773207,0.177931341,-2.490607447,{"v":2.68069e-05,"d":"2.68E-05"},{"v":1.96436e-05,"d":"1.96E-05"},"down","yes","Mcoln2","protein_coding","chr2:235053816-235102702:+","gi|84781670|ref|NP_001034094.1|",2954,0,"mucolipin-2 [Rattus norvegicus]","gi|84781669|ref|NM_001039005.1|",2504,0,"Rattus norvegicus mucolipin 2 (Mcoln2), mRNA","Q8K595",1052,0,"Mucolipin-2",".",".",".",".","pfam08016","PKD_channel","Polycystin cation channel. This family contains the cation channel region of PKD1 and PKD2 proteins.","GO:0032722|positive regulation of chemokine production;GO:0051209|release of sequestered calcium ion into cytosol;GO:0071639|positive regulation of monocyte chemotactic protein-1 production;GO:0071642|positive regulation of macrophage inflammatory protein 1 alpha production;GO:0071651|positive regulation of chemokine (C-C motif) ligand 5 production;GO:1905517|macrophage migration;GO:1990266|neutrophil migration;GO:2000341|regulation of chemokine (C-X-C motif) ligand 2 production;GO:2000343|positive regulation of chemokine (C-X-C motif) ligand 2 production;","GO:0010008|endosome membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0055037|recycling endosome;","GO:0042802|identical protein binding;GO:0072345|NAADP-sensitive calcium-release channel activity;","K04993","MCOLN2, TRPML2; mucolipin 2"]
["ENSRNOG00000047040",8,0.514643505,34,2.195103228,0.234450708,-2.092643461,{"v":3.10914e-05,"d":"3.11E-05"},{"v":2.26554E-5,"d":"2.27E-05"},"down","yes","Lhb","protein_coding","chr1:95898267-95901963:+","gi|293355937|ref|XP_002728800.1|",1620,0,"PREDICTED: uncharacterized protein LOC100359572 [Rattus norvegicus]","gi|904023|gb|U25802.1|U25802",2126,0,"Rattus norvegicus testicular luteinizing hormone beta subunit (TLHB2) mRNA, complete cds","P01230",207,{"v":7e-61,"d":"7.00E-61"},"Lutropin subunit beta",".",".",".",".","pfam00007","Cys_knot","Cystine-knot domain. The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.","GO:0007165|signal transduction;GO:0007186|G protein-coupled receptor signaling pathway;GO:0008150|biological_process;GO:0035471|luteinizing hormone signaling pathway involved in ovarian follicle development;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;","GO:0003674|molecular_function;GO:0005179|hormone activity;","K08521","LHB; lutropin subunit beta"]
["ENSRNOG00000064307",8,0.514643505,34,2.195103228,0.234450708,-2.092643461,{"v":3.10914e-05,"d":"3.11E-05"},{"v":2.26554E-5,"d":"2.27E-05"},"down","yes","ENSRNOG00000064307","lncRNA","chr18:6367875-6447255:+",".",".",".",".","gi|672082851|ref|XR_596912.1|",1559,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102551724 (LOC102551724), transcript variant X5, ncRNA",".",".",".",".",".",".",".",".","pfam14288","FKS1_dom1","1,3-beta-glucan synthase subunit FKS1, domain-1. The FKS1_dom1 domain is likely to be the 'Class I' region just N-terminal to the first set of transmembrane helices that is involved in 1,3-beta-glucan synthesis itself. This family is found on proteins with family Glucan_synthase, pfam02364.",".",".",".",".","."]
["ENSRNOG00000002753",38,2.444556651,83,5.358634351,0.456190233,-1.132292537,{"v":3.19688e-05,"d":"3.20E-05"},{"v":2.32679e-05,"d":"2.33E-05"},"down","yes","Adam11","protein_coding","chr10:87724234-87741562:+","gi|564374356|ref|XP_006247442.1|",3783,0,"PREDICTED: disintegrin and metalloproteinase domain-containing protein 11 isoform X2 [Rattus norvegicus]","gi|672068832|ref|XM_006247380.2|",3110,0,"PREDICTED: Rattus norvegicus ADAM metallopeptidase domain 11 (Adam11), transcript variant X2, mRNA","Q9R1V4",1440,0,"Disintegrin and metalloproteinase domain-containing protein 11",".",".",".",".","pfam01421","Reprolysin","Reprolysin (M12B) family zinc metalloprotease. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as human ADAM8 and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.","GO:0006508|proteolysis;GO:0007229|integrin-mediated signaling pathway;","GO:0016021|integral component of membrane;","GO:0004222|metalloendopeptidase activity;","K16067","ADAM11; disintegrin and metalloproteinase domain-containing protein 11 [EC:3.4.24.-]"]
["ENSRNOG00000066902",30,1.929913146,71,4.583892036,0.421020637,-1.248037143,{"v":3.24433e-05,"d":"3.24E-05"},{"v":2.35923e-05,"d":"2.36E-05"},"down","yes","ENSRNOG00000066902","pseudogene","chr10:91870520-91871959:+","gi|70794784|ref|NP_001020571.1|",922,{"v":2E-119,"d":"2.00E-119"},"survival of motor neuron-related-splicing factor 30 [Rattus norvegicus]","gi|672025356|ref|XM_008775413.1|",1352,0,"PREDICTED: Rattus norvegicus hypothetical LOC100363406 (LOC100363406), transcript variant X1, mRNA","Q4QQU6",359,{"v":7e-121,"d":"7.00E-121"},"Survival of motor neuron-related-splicing factor 30",".",".",".",".","pfam06003","SMN","Survival motor neuron protein (SMN). This family consists of several eukaryotic survival motor neuron (SMN) proteins. The Survival of Motor Neurons (SMN) protein, the product of the spinal muscular atrophy-determining gene, is part of a large macromolecular complex (SMN complex) that functions in the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs). The SMN complex functions as a specificity factor essential for the efficient assembly of Sm proteins on U snRNAs and likely protects cells from illicit, and potentially deleterious, non-specific binding of Sm proteins to RNAs.",".",".",".",".","."]
["ENSRNOG00000061070",23,1.479600078,60,3.873711579,0.381959278,-1.388509259,{"v":3.35516e-05,"d":"3.36E-05"},{"v":2.4361e-05,"d":"2.44E-05"},"down","yes","Irf4","protein_coding","chr17:33721811-33740070:-","gi|157816963|ref|NP_001099578.1|",2438,0,"interferon regulatory factor 4 [Rattus norvegicus]","gi|157816962|ref|NM_001106108.1|",4765,0,"Rattus norvegicus interferon regulatory factor 4 (Irf4), mRNA","Q64287",928,0,"Interferon regulatory factor 4",".",".",".",".","pfam10401","IRF-3","Interferon-regulatory factor 3. This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1).  Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.","GO:0002376|immune system process;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008150|biological_process;GO:0032733|positive regulation of interleukin-10 production;GO:0032736|positive regulation of interleukin-13 production;GO:0032743|positive regulation of interleukin-2 production;GO:0032753|positive regulation of interleukin-4 production;GO:0034122|negative regulation of toll-like receptor signaling pathway;GO:0042832|defense response to protozoan;GO:0043011|myeloid dendritic cell differentiation;GO:0043388|positive regulation of DNA binding;GO:0043966|histone H3 acetylation;GO:0043967|histone H4 acetylation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0072540|T-helper 17 cell lineage commitment;GO:0120162|positive regulation of cold-induced thermogenesis;","GO:0000786|nucleosome;GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987|proximal promoter sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003700|DNA-binding transcription factor activity;GO:0003713|transcription coactivator activity;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09445","IRF4; interferon regulatory factor 4"]
["ENSRNOG00000016203",20,1.286608764,55,3.550902281,0.362332912,-1.464612238,{"v":3.56332e-05,"d":"3.56E-05"},{"v":2.58264e-05,"d":"2.58E-05"},"down","yes","Efna2","protein_coding","chr7:9516429-9527061:-","gi|247269362|ref|NP_031935.3|",1043,{"v":4e-139,"d":"4.00E-139"},"ephrin-A2 precursor [Mus musculus]","gi|274327666|ref|NM_001168670.1|",1177,0,"Rattus norvegicus ephrin A2 (Efna2), mRNA","P52801",406,{"v":1e-140,"d":"1.00E-140"},"Ephrin-A2",".",".",".",".","pfam00812","Ephrin","Ephrin.","GO:0007411|axon guidance;GO:0021772|olfactory bulb development;GO:0030316|osteoclast differentiation;GO:0042472|inner ear morphogenesis;GO:0046849|bone remodeling;GO:0048013|ephrin receptor signaling pathway;","GO:0005886|plasma membrane;GO:0031225|anchored component of membrane;GO:0031594|neuromuscular junction;GO:0043204|perikaryon;","GO:0046875|ephrin receptor binding;","K05462","EFNA; ephrin-A"]
["ENSRNOG00000047730",0,0.032165219,16,1.032989754,0.031137985,-5.005180619,{"v":3.69526e-05,"d":"3.70E-05"},{"v":2.67318E-5,"d":"2.67E-05"},"down","yes","Tnfsf14","protein_coding","chr9:2069104-2073216:-","gi|972854014|tpe|CTQ86172.1|",1463,0,"TPA: tumor necrosis factor ligand 1d [Rattus norvegicus]","gi|972854013|tpe|LN874407.1|",936,0,"TPA_inf: Rattus norvegicus mRNA for tumor necrosis factor ligand 1d (Tnlg1d gene)","Q9QYH9",444,{"v":6e-155,"d":"6.00E-155"},"Tumor necrosis factor ligand superfamily member 14",".",".",".",".","pfam00229","TNF","TNF(tumor Necrosis Factor) family.","GO:0006915|apoptotic process;GO:0006955|immune response;GO:0010820|positive regulation of T cell chemotaxis;GO:0031295|T cell costimulation;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045663|positive regulation of myoblast differentiation;GO:0071260|cellular response to mechanical stimulus;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1901741|positive regulation of myoblast fusion;","GO:0016021|integral component of membrane;","GO:0005102|signaling receptor binding;GO:0005164|tumor necrosis factor receptor binding;GO:0042802|identical protein binding;GO:0043027|cysteine-type endopeptidase inhibitor activity involved in apoptotic process;","K05477","TNFSF14, LIGHT, CD258; tumor necrosis factor ligand superfamily member 14"]
["ENSRNOG00000048363",0,0.032165219,16,1.032989754,0.031137985,-5.005180619,{"v":3.69526e-05,"d":"3.70E-05"},{"v":2.67318E-5,"d":"2.67E-05"},"down","yes","Dnah5","protein_coding","chr2:78937800-79254890:+","gi|148676944|gb|EDL08891.1|",23192,0,"dynein, axonemal, heavy chain 5, isoform CRA_a, partial [Mus musculus]","gi|342672104|ref|NM_133365.3|",11937,0,"Mus musculus dynein, axonemal, heavy chain 5 (Dnah5), mRNA","Q8VHE6",8926,0,"Dynein heavy chain 5, axonemal","YKR054c",409,{"v":6e-113,"d":"6.00E-113"},"COG5245","pfam03028","Dynein_heavy","Dynein heavy chain and region D6 of dynein motor. This family represents the C-terminal region of dynein heavy chain. The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained.","GO:0003341|cilium movement;GO:0003351|epithelial cilium movement;GO:0007018|microtubule-based movement;GO:0007368|determination of left/right symmetry;GO:0007507|heart development;GO:0008150|biological_process;GO:0021670|lateral ventricle development;GO:0030317|flagellated sperm motility;GO:0036158|outer dynein arm assembly;GO:0051649|establishment of localization in cell;GO:0060271|cilium assembly;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005737|cytoplasm;GO:0005858|axonemal dynein complex;GO:0005874|microtubule;GO:0005930|axoneme;GO:0030286|dynein complex;GO:0031514|motile cilium;GO:0036157|outer dynein arm;GO:0097729|9+2 motile cilium;","GO:0003674|molecular_function;GO:0003777|microtubule motor activity;GO:0005524|ATP binding;GO:0008569|ATP-dependent microtubule motor activity, minus-end-directed;GO:0045505|dynein intermediate chain binding;GO:0051959|dynein light intermediate chain binding;","K10408","DNAH; dynein axonemal heavy chain"]
["ENSRNOG00000066013",35,2.251565336,78,5.035825053,0.447109523,-1.161299821,{"v":3.88346e-05,"d":"3.88E-05"},{"v":2.80329e-05,"d":"2.80E-05"},"down","yes","ENSRNOG00000066013","pseudogene","chr18:23626523-23628408:-","gi|795093282|ref|XP_011815463.1|",1923,0,"PREDICTED: actin, cytoplasmic 2 isoform X1 [Colobus angolensis palliatus]","gi|672083092|ref|XM_002728532.4|",1677,0,"PREDICTED: Rattus norvegicus POTE ankyrin domain family, member F (Potef), mRNA","A2BDB0",739,0,"Actin, cytoplasmic 2","SPBC32H8.12c",689,0,"COG5277","pfam00022","Actin","Actin.",".",".",".",".","."]
["ENSRNOG00000021513",33,2.12290446,75,4.842139474,0.438422824,-1.18960519,{"v":3.91361E-5,"d":"3.91E-05"},{"v":2.82434e-05,"d":"2.82E-05"},"down","yes","Rtn4rl2","protein_coding","chr3:69955169-69971488:-","gi|31077112|ref|NP_852045.1|",1905,0,"reticulon-4 receptor-like 2 precursor [Rattus norvegicus]","gi|880857448|ref|XM_005065082.2|",1392,0,"PREDICTED: Mesocricetus auratus reticulon 4 receptor-like 2 (Rtn4rl2), transcript variant X1, mRNA","Q80WD1",738,0,"Reticulon-4 receptor-like 2","SPy1798",72,{"v":3e-12,"d":"3.00E-12"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0007166|cell surface receptor signaling pathway;GO:0010977|negative regulation of neuron projection development;GO:0022038|corpus callosum development;","GO:0005615|extracellular space;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0030424|axon;GO:0030425|dendrite;GO:0031012|extracellular matrix;GO:0043005|neuron projection;GO:0043204|perikaryon;GO:0045121|membrane raft;GO:0046658|anchored component of plasma membrane;","GO:0005515|protein binding;GO:0038023|signaling receptor activity;","K16661","RTN4RL2, NGR2; reticulon-4 receptor-like 2"]
["ENSRNOG00000016278",4,0.257321753,25,1.614046491,0.159426481,-2.649036809,{"v":4.02899e-05,"d":"4.03E-05"},{"v":2.90394e-05,"d":"2.90E-05"},"down","yes","Ccl17","protein_coding","chr19:10202128-10203819:-","gi|149032433|gb|EDL87324.1|",432,{"v":1E-51,"d":"1.00E-51"},"chemokine (C-C motif) ligand 17 [Rattus norvegicus]","gi|755526535|ref|XM_011248331.1|",285,{"v":5e-146,"d":"5.00E-146"},"PREDICTED: Mus musculus chemokine (C-C motif) ligand 17 (Ccl17), transcript variant X3, mRNA","Q95N01",111,{"v":7e-30,"d":"7.00E-30"},"C-C motif chemokine 17",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0002548|monocyte chemotaxis;GO:0006954|inflammatory response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0008150|biological_process;GO:0030593|neutrophil chemotaxis;GO:0031640|killing of cells of other organism;GO:0043547|positive regulation of GTPase activity;GO:0045662|negative regulation of myoblast differentiation;GO:0048247|lymphocyte chemotaxis;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098|chemokine-mediated signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;","GO:0005575|cellular_component;GO:0005615|extracellular space;","GO:0008009|chemokine activity;GO:0031729|CCR4 chemokine receptor binding;GO:0048020|CCR chemokine receptor binding;","K21083","CCL17; C-C motif chemokine 17"]
["ENSRNOG00000024338",16,1.029287011,48,3.098969263,0.332138503,-1.59014312,{"v":4.08057e-05,"d":"4.08E-05"},{"v":2.93963e-05,"d":"2.94E-05"},"down","yes","ENSRNOG00000024338","protein_coding","chr6:39790913-39797090:-","gi|672055866|ref|XP_008762839.1|",748,{"v":4E-95,"d":"4.00E-95"},"PREDICTED: uncharacterized protein C2orf50 homolog isoform X2 [Rattus norvegicus]","gi|672055865|ref|XM_008764617.1|",549,0,"PREDICTED: Rattus norvegicus hypothetical protein LOC690276 (LOC690276), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam14945","LLC1","Normal lung function maintenance, Low in Lung Cancer 1 protein. This protein is part of a family found in eukaryotes. It is 137 amino acids long in protein sequence length and mass is approximately 15.7 kDa. The protein is present in the normal lung epithelium, but absent or downregulated in most primary non-small lung cancers. The gene is known as Low in Lung Cancer 1 (LLC1). This protein is thought to have a role in the maintenance of normal lung function and its absence may lead to lung tumorigenesis.",".",".",".",".","."]
["ENSRNOG00000068045",2,0.128660876,20,1.291237193,0.099641551,-3.327108714,{"v":4.11316e-05,"d":"4.11E-05"},{"v":2.9605e-05,"d":"2.96E-05"},"down","yes","Dmrta2","protein_coding","chr5:124805883-124811630:+","gi|532020056|ref|XP_005353638.1|",1336,{"v":4e-170,"d":"4.00E-170"},"PREDICTED: doublesex- and mab-3-related transcription factor A2 isoform X1 [Microtus ochrogaster]","gi|564352179|ref|XM_006238589.1|",2945,0,"PREDICTED: Rattus norvegicus DMRT-like family A2 (Dmrta2), transcript variant X1, mRNA","A6QQ94",515,{"v":3e-170,"d":"3.00E-170"},"Doublesex- and mab-3-related transcription factor A2",".",".",".",".","pfam00751","DM","DM DNA binding domain. The DM domain is named after dsx and mab-3. dsx contains a single amino-terminal DM domain, whereas mab-3 contains two amino-terminal domains. The DM domain has a pattern of conserved zinc chelating residues C2H2C4. The dsx DM domain has been shown to dimerise and bind palindromic DNA.",".",".",".",".","."]
["ENSRNOG00000000854",19,1.222278326,53,3.421778562,0.357205559,-1.48517356,{"v":4.12107e-05,"d":"4.12E-05"},{"v":2.96544e-05,"d":"2.97E-05"},"down","yes","Ncr3","protein_coding","chr20:3638240-3643799:-","gi|260166676|ref|NP_861543.2|",917,{"v":2E-121,"d":"2.00E-121"},"natural cytotoxicity triggering receptor 3 precursor [Rattus norvegicus]","gi|30314389|gb|AY273824.1|",899,0,"Rattus norvegicus NKp30 (Nkp30) mRNA, complete cds","Q8CFD9",348,{"v":1E-119,"d":"1.00E-119"},"Natural cytotoxicity triggering receptor 3",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0002429|immune response-activating cell surface receptor signaling pathway;GO:0030101|natural killer cell activation;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0042802|identical protein binding;","K06743","NCR3, CD337; natural cytotoxicity triggering receptor 3"]
["ENSRNOG00000067369",36,2.315895775,79,5.100386913,0.454062763,-1.139036366,{"v":4.56374e-05,"d":"4.56E-05"},{"v":3.27161e-05,"d":"3.27E-05"},"down","yes","Chml","protein_coding","chr13:87589298-87619862:-","gi|157817191|ref|NP_001102994.1|",3208,0,"rab proteins geranylgeranyltransferase component A 2 [Rattus norvegicus]","gi|157817190|ref|NM_001109524.1|",1866,0,"Rattus norvegicus choroideremia-like (Chml), mRNA","Q9QZD5",1095,0,"Rab proteins geranylgeranyltransferase component A 2","YER136w",139,{"v":3e-33,"d":"3.00E-33"},"COG5044","pfam00996","GDI","GDP dissociation inhibitor.",".",".",".",".","."]
["ENSRNOG00000047446",15,0.964956573,46,2.969845544,0.3249181,-1.62185198,{"v":4.61871e-05,"d":"4.62E-05"},{"v":3.30977E-5,"d":"3.31E-05"},"down","yes","Foxc2","protein_coding","chr19:49185662-49188737:+","gi|156119589|ref|NP_001095150.1|",1977,0,"forkhead box protein C2 [Rattus norvegicus]","gi|156119588|ref|NM_001101680.1|",2703,0,"Rattus norvegicus forkhead box C2 (Foxc2), mRNA","Q63246",766,0,"Forkhead box protein C2","SPBC4C3.05",99.4,{"v":2e-20,"d":"2.00E-20"},"COG5025","pfam00250","Fork_head","Fork head domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001501|skeletal system development;GO:0001503|ossification;GO:0001568|blood vessel development;GO:0001569|branching involved in blood vessel morphogenesis;GO:0001656|metanephros development;GO:0001657|ureteric bud development;GO:0001756|somitogenesis;GO:0001822|kidney development;GO:0001945|lymph vessel development;GO:0001946|lymphangiogenesis;GO:0001974|blood vessel remodeling;GO:0003007|heart morphogenesis;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007219|Notch signaling pathway;GO:0007507|heart development;GO:0008283|cell proliferation;GO:0008286|insulin receptor signaling pathway;GO:0009653|anatomical structure morphogenesis;GO:0009725|response to hormone;GO:0010595|positive regulation of endothelial cell migration;GO:0014032|neural crest cell development;GO:0030154|cell differentiation;GO:0030199|collagen fibril organization;GO:0033630|positive regulation of cell adhesion mediated by integrin;GO:0035050|embryonic heart tube development;GO:0035470|positive regulation of vascular wound healing;GO:0043010|camera-type eye development;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046620|regulation of organ growth;GO:0048010|vascular endothelial growth factor receptor signaling pathway;GO:0048341|paraxial mesoderm formation;GO:0048343|paraxial mesodermal cell fate commitment;GO:0048701|embryonic cranial skeleton morphogenesis;GO:0048703|embryonic viscerocranium morphogenesis;GO:0048704|embryonic skeletal system morphogenesis;GO:0048844|artery morphogenesis;GO:0055010|ventricular cardiac muscle tissue morphogenesis;GO:0060038|cardiac muscle cell proliferation;GO:0072011|glomerular endothelium development;GO:0072112|glomerular visceral epithelial cell differentiation;GO:0072144|glomerular mesangial cell development;GO:0090050|positive regulation of cell migration involved in sprouting angiogenesis;GO:0097746|regulation of blood vessel diameter;GO:0120163|negative regulation of cold-induced thermogenesis;GO:1902257|negative regulation of apoptotic process involved in outflow tract morphogenesis;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0016604|nuclear body;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001216|bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0031490|chromatin DNA binding;GO:0042802|identical protein binding;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;GO:1990841|promoter-specific chromatin binding;","K09396","FOXC; forkhead box protein C"]
["ENSRNOG00000002640",1,0.064330438,17,1.097551614,0.058612677,-4.092643461,{"v":4.63879e-05,"d":"4.64E-05"},{"v":3.32166e-05,"d":"3.32E-05"},"down","yes","Serpinb5","protein_coding","chr13:22985557-23005756:+","gi|672073583|ref|XP_008767627.1|",2347,0,"PREDICTED: serpin B5 isoform X1 [Rattus norvegicus]","gi|672073582|ref|XM_008769405.1|",2722,0,"PREDICTED: Rattus norvegicus serpin peptidase inhibitor, clade B (ovalbumin), member 5 (Serpinb5), transcript variant X1, mRNA","P70564",756,0,"Serpin B5","MA3388",167,{"v":1e-43,"d":"1.00E-43"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0002009|morphogenesis of an epithelium;GO:0010951|negative regulation of endopeptidase activity;GO:0030198|extracellular matrix organization;GO:0050678|regulation of epithelial cell proliferation;GO:0060512|prostate gland morphogenesis;","GO:0005615|extracellular space;GO:0005737|cytoplasm;","GO:0004867|serine-type endopeptidase inhibitor activity;","K10139","SERPINB5; serpin B5"]
["ENSRNOG00000005619",1,0.064330438,17,1.097551614,0.058612677,-4.092643461,{"v":4.63879e-05,"d":"4.64E-05"},{"v":3.32166e-05,"d":"3.32E-05"},"down","yes","Misp3","protein_coding","chr19:24140033-24142631:+","gi|157820703|ref|NP_001100631.1|",630,{"v":2E-73,"d":"2.00E-73"},"uncharacterized protein LOC304650 [Rattus norvegicus]","gi|672084402|ref|XM_006255249.2|",999,0,"PREDICTED: Rattus norvegicus hypothetical LOC304650 (RGD1310262), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam15304","AKAP2_C","A-kinase anchor protein 2 C-terminus. This family includes the C-terminus of A-kinase anchor protein 2 (AKAP2). It includes the site where the regulatory subunits (RII) of protein kinase AII binds.",".",".",".",".","."]
["ENSRNOG00000031342",9,0.578973944,35,2.259665088,0.256221131,-1.964538635,{"v":4.9818e-05,"d":"4.98E-05"},{"v":3.55613e-05,"d":"3.56E-05"},"down","yes","AABR07063082.1","protein_coding","chr6:1714435-1715952:-","gi|564307444|ref|XP_006225874.1|",2628,0,"PREDICTED: UDP-N-acetylhexosamine pyrophosphorylase isoform X1 [Rattus norvegicus]","gi|672055460|ref|XM_008764496.1|",1518,0,"PREDICTED: Rattus norvegicus UDP-N-acteylglucosamine pyrophosphorylase 1-like 2 (Uap1l2), transcript variant X2, mRNA","Q91YN5",969,0,"UDP-N-acetylhexosamine pyrophosphorylase","YDL103c",292,{"v":2E-91,"d":"2.00E-91"},"COG4284","pfam01704","UDPGP","UTP--glucose-1-phosphate uridylyltransferase. This family consists of UTP--glucose-1-phosphate uridylyltransferases, EC:2.7.7.9. Also known as UDP-glucose pyrophosphorylase (UDPGP) and Glucose-1-phosphate uridylyltransferase. UTP--glucose-1-phosphate uridylyltransferase catalyses the interconversion of MgUTP + glucose-1-phosphate and UDP-glucose + MgPPi. UDP-glucose is an important intermediate in mammalian carbohydrate interconversion involved in various metabolic roles depending on tissue type. In Dictyostelium (slime mold) mutants in this enzyme abort the development cycle. Also within the family is UDP-N-acetylglucosamine or AGX1 and two hypothetical proteins from Borrelia burgdorferi the lyme disease spirochaete.",".",".",".",".","."]
["ENSRNOG00000008939",14,0.900626135,44,2.840721825,0.317041298,-1.657257316,{"v":5.19545e-05,"d":"5.20E-05"},{"v":3.7017e-05,"d":"3.70E-05"},"down","yes","Nxph1","protein_coding","chr4:36997669-37311132:+","gi|148681975|gb|EDL13922.1|",1628,0,"neurexophilin 1, isoform CRA_a, partial [Mus musculus]","gi|77404424|ref|NM_012994.2|",2440,0,"Rattus norvegicus neurexophilin 1 (Nxph1), mRNA","Q63366",564,0,"Neurexophilin-1",".",".",".",".","pfam06312","Neurexophilin","Neurexophilin. This family consists of mammalian neurexophilin proteins. Mammalian brains contain four different neurexophilin proteins. Neurexophilins form a family of related glycoproteins that are proteolytically processed after synthesis and bind to alpha-neurexins. The structure and characteristics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins.",".","GO:0005576|extracellular region;","GO:0005102|signaling receptor binding;","K16656","NXPH1; neurexophilin-1"]
["ENSRNOG00000050650",38,2.444556651,81,5.229510632,0.467454189,-1.097103109,{"v":6.19602e-05,"d":"6.20E-05"},{"v":4.38506e-05,"d":"4.39E-05"},"down","yes","Ttc16","protein_coding","chr3:16048565-16064547:-","gi|672016607|ref|XP_003753757.2|",3368,0,"PREDICTED: tetratricopeptide repeat protein 16 [Rattus norvegicus]","gi|672016606|ref|XM_003753709.3|",1651,0,"PREDICTED: Rattus norvegicus tetratricopeptide repeat domain 16 (LOC100362059), mRNA",".",".",".",".","FN1787",66.2,{"v":2e-10,"d":"2.00E-10"},"COG0457","pfam13414","TPR_11","TPR repeat.",".",".",".",".","."]
["ENSRNOG00000046191",26,1.672591393,63,4.067397158,0.411219099,-1.282020825,{"v":6.40238e-05,"d":"6.40E-05"},{"v":4.52717e-05,"d":"4.53E-05"},"down","yes","Cgas","protein_coding","chr8:79294511-79305496:-","gi|109485035|ref|XP_001060106.1|",2252,0,"PREDICTED: cyclic GMP-AMP synthase isoform X1 [Rattus norvegicus]","gi|672023102|ref|XM_001060106.3|",1903,0,"PREDICTED: Rattus norvegicus Mab-21 domain containing 1 (Mb21d1), transcript variant X1, mRNA","Q8C6L5",777,0,"Cyclic GMP-AMP synthase",".",".",".",".","pfam03281","Mab-21","Mab-21 protein. This family contains Mab-21 and Mab-21 like proteins. In C. elegans these proteins are required for several aspects of embryonic development.","GO:0002218|activation of innate immune response;GO:0002230|positive regulation of defense response to virus by host;GO:0002637|regulation of immunoglobulin production;GO:0006974|cellular response to DNA damage stimulus;GO:0008340|determination of adult lifespan;GO:0010753|positive regulation of cGMP-mediated signaling;GO:0032479|regulation of type I interferon production;GO:0032481|positive regulation of type I interferon production;GO:0038001|paracrine signaling;GO:0043950|positive regulation of cAMP-mediated signaling;GO:0050776|regulation of immune response;GO:0050863|regulation of T cell activation;GO:0051607|defense response to virus;GO:0071360|cellular response to exogenous dsRNA;GO:2000042|negative regulation of double-strand break repair via homologous recombination;GO:2000774|positive regulation of cellular senescence;","GO:0005634|nucleus;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0035861|site of double-strand break;","GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003690|double-stranded DNA binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0061501|cyclic-GMP-AMP synthase activity;","K17834","MB21D1; cyclic GMP-AMP synthase [EC:2.7.7.86]"]
["ENSRNOG00000009168",0,0.032165219,15,0.968427895,0.03321385,-4.912071215,{"v":6.77086e-05,"d":"6.77E-05"},{"v":4.77178e-05,"d":"4.77E-05"},"down","yes","Sprr2d","protein_coding","chr2:177870434-177870679:-",".",".",".",".","gi|672016031|ref|XM_008775199.1|",246,{"v":1e-124,"d":"1.00E-124"},"PREDICTED: Rattus norvegicus small proline-rich protein 2D (Sprr2d), mRNA",".",".",".",".",".",".",".",".","pfam04143","Sulf_transp","Sulphur transport. This is an integral membrane protein. It is predicted to have a function in the transport of sulphur-containing molecules. It contains several conserved glycines and an invariant cysteine that is probably an important functional residue.","GO:0008585|female gonad development;GO:0031424|keratinization;GO:0032355|response to estradiol;","GO:0001533|cornified envelope;GO:0005634|nucleus;GO:0005737|cytoplasm;",".",".","."]
["ENSRNOG00000015359",0,0.032165219,15,0.968427895,0.03321385,-4.912071215,{"v":6.77086e-05,"d":"6.77E-05"},{"v":4.77178e-05,"d":"4.77E-05"},"down","yes","ENSRNOG00000015359","protein_coding","chr3:147165729-147207203:+","gi|392339666|ref|XP_001068716.3|",3307,0,"PREDICTED: rho GTPase-activating protein 40 isoform X1 [Rattus norvegicus]","gi|672047866|ref|XM_008762437.1|",2240,0,"PREDICTED: Rattus norvegicus Rho GTPase activating protein 40 (Arhgap40), transcript variant X2, mRNA","E9Q6X9",1118,0,"Rho GTPase-activating protein 40",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0007165|signal transduction;GO:0030833|regulation of actin filament polymerization;GO:0050790|regulation of catalytic activity;GO:0051056|regulation of small GTPase mediated signal transduction;","GO:0005737|cytoplasm;","GO:0005096|GTPase activator activity;","K20639","ARHGAP18_28_40; Rho GTPase-activating protein 18/28/40"]
["ENSRNOG00000062522",0,0.032165219,15,0.968427895,0.03321385,-4.912071215,{"v":6.77086e-05,"d":"6.77E-05"},{"v":4.77178e-05,"d":"4.77E-05"},"down","yes","ENSRNOG00000062522","lncRNA","chr2:180251264-180251809:+",".",".",".",".","gi|33342289|gb|AC105631.4|",393,0,"Rattus norvegicus 1 BAC CH230-132J4 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam15301","SLAIN","SLAIN motif-containing family. The SLAIN motif containing family is named after the presence of a SLAIN motif in SLAIN1. They are a family of microtubule plus-end tracking proteins.",".",".",".",".","."]
["ENSRNOG00000062766",0,0.032165219,15,0.968427895,0.03321385,-4.912071215,{"v":6.77086e-05,"d":"6.77E-05"},{"v":4.77178e-05,"d":"4.77E-05"},"down","yes","Ccdc198","protein_coding","chr15:22502687-22526992:-","gi|564317743|ref|XP_006221984.1|",1578,0,"PREDICTED: uncharacterized protein C14orf105 homolog isoform X1 [Rattus norvegicus]","gi|672028430|ref|XM_008768088.1|",1208,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102556129 (LOC102556129), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam15398","DUF4619","Domain of unknown function (DUF4619). This family of proteins is found in eukaryotes. Proteins in this family are typically between 128 and 299 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000071026",0,0.032165219,15,0.968427895,0.03321385,-4.912071215,{"v":6.77086e-05,"d":"6.77E-05"},{"v":4.77178e-05,"d":"4.77E-05"},"down","yes","ENSRNOG00000071026","IG_V_gene","chr4:102647703-102648017:+","gi|149037293|gb|EDL91768.1|",492,{"v":1E-61,"d":"1.00E-61"},"rCG64259, partial [Rattus norvegicus]","gi|672031027|ref|XM_003753081.2|",216,{"v":7e-108,"d":"7.00E-108"},"PREDICTED: Rattus norvegicus similar to Ig variable region, light chain (RGD1565617), mRNA","P01660",167,{"v":1E-52,"d":"1.00E-52"},"Ig kappa chain V-III region PC 3741/TEPC 111",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000033502",4,0.257321753,24,1.549484632,0.166069251,-2.59014312,{"v":7.07444E-5,"d":"7.07E-05"},{"v":4.97345e-05,"d":"4.97E-05"},"down","yes","Ribc2","protein_coding","chr7:116242863-116257863:+","gi|241666452|ref|NP_001013971.2|",1829,0,"RIB43A-like with coiled-coils protein 2 [Rattus norvegicus]","gi|62078626|ref|NM_001013949.1|",1308,0,"Rattus norvegicus RIB43A domain with coiled-coils 2 (Ribc2), mRNA",".",".",".",".",".",".",".",".","pfam05914","RIB43A","RIB43A. This family consists of several RIB43A-like eukaryotic proteins. Ciliary and flagellar microtubules contain a specialized set of protofilaments, termed ribbons, that are composed of tubulin and several associated proteins. RIB43A was first characterized in the unicellular biflagellate, Chlamydomonas reinhardtii although highly related sequences are present in several higher eukaryotes including humans. The function of this protein is unknown although the structure of RIB43A and its association with the specialized protofilament ribbons and with basal bodies is relevant to the proposed role of ribbons in forming and stabilizing doublet and triplet microtubules and in organizing their three-dimensional structure. Human RIB43A homologues could represent a structural requirement in centriole replication in dividing cells.",".",".",".","K25475","RIBC; RIB43A-like with coiled-coils protein"]
["ENSRNOG00000030093",2,0.128660876,19,1.226675333,0.104885843,-3.253108133,{"v":7.5351e-05,"d":"7.54E-05"},{"v":5.28365e-05,"d":"5.28E-05"},"down","yes","Defa5","protein_coding","chr16:70342530-70344836:-","gi|564389781|ref|XP_006253429.1|",511,{"v":3e-63,"d":"3.00E-63"},"PREDICTED: alpha-defensin 5, Paneth cell-specific isoform X1 [Rattus norvegicus]","gi|564389780|ref|XM_006253367.1|",487,0,"PREDICTED: Rattus norvegicus defensin, alpha 5, Paneth cell-specific (Defa5), transcript variant X1, mRNA","Q62715",157,{"v":4e-48,"d":"4.00E-48"},"Neutrophil antibiotic peptide NP-2",".",".",".",".","pfam00879","Defensin_propep","Defensin propeptide.","GO:0002227|innate immune response in mucosa;GO:0019731|antibacterial humoral response;GO:0031640|killing of cells of other organism;GO:0042742|defense response to bacterium;GO:0045087|innate immune response;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:0050832|defense response to fungus;GO:0051673|membrane disruption in other organism;GO:0051873|killing by host of symbiont cells;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0071222|cellular response to lipopolysaccharide;GO:1905710|positive regulation of membrane permeability;","GO:0005615|extracellular space;GO:0030496|midbody;GO:0043231|intracellular membrane-bounded organelle;","GO:0042803|protein homodimerization activity;","K05230","DEFA; defensin, alpha"]
["ENSRNOG00000054522",2,0.128660876,19,1.226675333,0.104885843,-3.253108133,{"v":7.5351e-05,"d":"7.54E-05"},{"v":5.28365e-05,"d":"5.28E-05"},"down","yes","U6","snRNA","chr12:20644365-20644470:-",".",".",".",".","gi|23462861|gb|AC091617.2|",106,{"v":3e-47,"d":"3.00E-47"},"Rattus norvegicus strain Brown Norway clone RP31-371K3, complete sequence",".",".",".",".",".",".",".",".","pfam05785","CNF1","Rho-activating domain of cytotoxic necrotizing factor. This family consists of several bacterial cytotoxic necrotizing factor proteins as well as related dermonecrotic toxin (DNT) from Bordetella species. Cytotoxic necrotizing factor 1 (CNF1) causes necrosis of rabbit skin and re-organisation of the actin cytoskeleton in cultured cells. Bordetella dermonecrotic toxin (DNT) stimulates the assembly of actin stress fibres and focal adhesions by deamidating or polyaminating Gln63 of the small GTPase Rho. DNT is an A-B toxin which is composed of an N-terminal receptor-binding (B) domain and a C-terminal enzymatically active (A) domain.",".",".",".",".","."]
["ENSRNOG00000063799",42,2.701878404,86,5.55231993,0.486621527,-1.039127951,{"v":7.86858e-05,"d":"7.87E-05"},{"v":5.50802e-05,"d":"5.51E-05"},"down","yes","ENSRNOG00000063799","lncRNA","chr18:23543616-23545513:-","gi|148682433|gb|EDL14380.1|",160,{"v":5e-10,"d":"5.00E-10"},"mCG1026625 [Mus musculus]","gi|40363560|gb|AC131761.4|",703,0,"Mus musculus BAC clone RP24-228J4 from chromosome 18, complete sequence",".",".",".",".",".",".",".",".","pfam14018","DUF4234","Domain of unknown function (DUF4234). This presumed integral membrane protein domain is functionally uncharacterized. This domain family is found in bacteria and archaea, and is approximately 70 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000061376",5,0.321652191,26,1.678608351,0.191618367,-2.383692243,{"v":7.98e-05,"d":"7.98E-05"},{"v":5.58191e-05,"d":"5.58E-05"},"down","yes","Psca","protein_coding","chr7:106595284-106609746:+","gi|285403261|ref|NP_001165577.1|",443,{"v":4e-49,"d":"4.00E-49"},"prostate stem cell antigen precursor [Rattus norvegicus]","gi|56090358|ref|NM_001007658.1|",939,0,"Rattus norvegicus thioesterase superfamily member 6 (Them6), mRNA","P57096",153,{"v":1E-42,"d":"1.00E-42"},"Prostate stem cell antigen",".",".",".",".","pfam00021","UPAR_LY6","u-PAR/Ly-6 domain. This extracellular disulphide bond rich domain is related to pfam00087.",".",".",".",".","."]
["ENSRNOG00000016149",9,0.578973944,34,2.195103228,0.263757046,-1.922718459,{"v":8.09872e-05,"d":"8.10E-05"},{"v":5.66148e-05,"d":"5.66E-05"},"down","yes","Hoxc10","protein_coding","chr7:134103643-134108966:+","gi|822549652|ref|NP_001295565.1|",1732,0,"homeobox protein Hox-C10 [Rattus norvegicus]","gi|822549651|ref|NM_001308636.1|",1866,0,"Rattus norvegicus homeo box C10 (Hoxc10), mRNA","P31257",667,0,"Homeobox protein Hox-C10","SPAC32A11.03c",51.2,1e-05,"COG5576","pfam00046","Homeobox","Homeobox domain.","GO:0001501|skeletal system development;GO:0006357|regulation of transcription by RNA polymerase II;GO:0009952|anterior/posterior pattern specification;GO:0009954|proximal/distal pattern formation;GO:0021520|spinal cord motor neuron cell fate specification;GO:0030326|embryonic limb morphogenesis;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050905|neuromuscular process;GO:0120163|negative regulation of cold-induced thermogenesis;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0016604|nuclear body;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837|sequence-specific double-stranded DNA binding;","K17444","HOXC10; homrobox protein Hox-C10"]
["ENSRNOG00000021560",17,1.093617449,48,3.098969263,0.352897159,-1.502680279,{"v":8.27096e-05,"d":"8.27E-05"},{"v":5.77552e-05,"d":"5.78E-05"},"down","yes","Cass4","protein_coding","chr3:161163436-161202186:+","gi|564344734|ref|XP_006235741.1|",4005,0,"PREDICTED: cas scaffolding protein family member 4 isoform X1 [Rattus norvegicus]","gi|672048056|ref|XM_006235679.2|",3610,0,"PREDICTED: Rattus norvegicus Cas scaffolding protein family member 4 (Cass4), transcript variant X1, mRNA","Q08EC4",1264,0,"Cas scaffolding protein family member 4",".",".",".",".","pfam08824","Serine_rich","Serine rich protein interaction domain. This is a serine rich domain that is found in the docking protein p130(cas) (Crk-associated substrate). This domain folds into a four helix bundle which is associated with protein-protein interactions.","GO:0007155|cell adhesion;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0016477|cell migration;GO:0030335|positive regulation of cell migration;GO:0051897|positive regulation of protein kinase B signaling;GO:0061098|positive regulation of protein tyrosine kinase activity;GO:0090527|actin filament reorganization;GO:1900026|positive regulation of substrate adhesion-dependent cell spreading;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005925|focal adhesion;","GO:1990782|protein tyrosine kinase binding;",".","."]
["ENSRNOG00000055858",6,0.385982629,28,1.80773207,0.213517609,-2.227573041,{"v":8.46977e-05,"d":"8.47E-05"},{"v":5.91074e-05,"d":"5.91E-05"},"down","yes","Myb","protein_coding","chr1:15939761-15973057:-","gi|564296048|ref|XP_006222900.1|",3674,0,"PREDICTED: transcriptional activator Myb isoform X1 [Rattus norvegicus]","gi|672012493|ref|XM_006222838.2|",5802,0,"PREDICTED: Rattus norvegicus similar to Myb proto-oncogene protein (C-myb) (predicted) (RGD1560020_predicted), transcript variant X1, mRNA","P06876",733,0,"Transcriptional activator Myb","ECU11g1690",154,{"v":2e-40,"d":"2.00E-40"},"COG5147","pfam09316","Cmyb_C","C-myb, C-terminal. Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumorigenesis.","GO:0000082|G1/S transition of mitotic cell cycle;GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001666|response to hypoxia;GO:0001701|in utero embryonic development;GO:0006338|chromatin remodeling;GO:0006355|regulation of transcription, DNA-templated;GO:0006816|calcium ion transport;GO:0010468|regulation of gene expression;GO:0017145|stem cell division;GO:0030099|myeloid cell differentiation;GO:0030183|B cell differentiation;GO:0032967|positive regulation of collagen biosynthetic process;GO:0043525|positive regulation of neuron apoptotic process;GO:0045624|positive regulation of T-helper cell differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048536|spleen development;GO:0048538|thymus development;GO:0048566|embryonic digestive tract development;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0048872|homeostasis of number of cells;GO:0051571|positive regulation of histone H3-K4 methylation;GO:0051574|positive regulation of histone H3-K9 methylation;GO:0060252|positive regulation of glial cell proliferation;GO:0070301|cellular response to hydrogen peroxide;GO:0071300|cellular response to retinoic acid;GO:0071354|cellular response to interleukin-6;GO:0071636|positive regulation of transforming growth factor beta production;GO:1901216|positive regulation of neuron death;GO:1901533|negative regulation of hematopoietic progenitor cell differentiation;GO:1904899|positive regulation of hepatic stellate cell proliferation;GO:1990830|cellular response to leukemia inhibitory factor;GO:2000491|positive regulation of hepatic stellate cell activation;GO:2000845|positive regulation of testosterone secretion;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0071987|WD40-repeat domain binding;","K09420","MYB, C-MYB; transcriptional activator Myb"]
["ENSRNOG00000007200",1,0.064330438,16,1.032989754,0.062275969,-4.005180619,{"v":8.6329e-05,"d":"8.63E-05"},{"v":6.01797e-05,"d":"6.02E-05"},"down","yes","Ikzf3","protein_coding","chr10:83465745-83553591:-","gi|157820409|ref|NP_001100517.1|",2744,0,"zinc finger protein Aiolos [Rattus norvegicus]","gi|157820408|ref|NM_001107047.1|",2333,0,"Rattus norvegicus IKAROS family zinc finger 3 (Ikzf3), mRNA","O08900",1013,0,"Zinc finger protein Aiolos",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0009617|response to bacterium;GO:0030888|regulation of B cell proliferation;GO:0042981|regulation of apoptotic process;GO:0045577|regulation of B cell differentiation;GO:0045619|regulation of lymphocyte differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0042826|histone deacetylase binding;GO:0043565|sequence-specific DNA binding;GO:1990841|promoter-specific chromatin binding;","K09220","IKZF, ZNFN1A; IKAROS family zinc finger protein"]
["ENSRNOG00000066977",1,0.064330438,16,1.032989754,0.062275969,-4.005180619,{"v":8.6329e-05,"d":"8.63E-05"},{"v":6.01797e-05,"d":"6.02E-05"},"down","yes","ENSRNOG00000066977","protein_coding","chr8:108236754-108241065:-","gi|148689252|gb|EDL21199.1|",462,{"v":4E-51,"d":"4.00E-51"},"mCG146219, partial [Mus musculus]","gi|672023321|ref|XR_348734.2|",958,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102551360 (LOC102551360), transcript variant X2, ncRNA","Q9WVF8",69.7,{"v":1e-12,"d":"1.00E-12"},"Tumor suppressor candidate 2",".",".",".",".","pfam15000","TUSC2","tumor suppressor candidate 2. This family of proteins are candidate tumor suppressors.",".",".",".",".","."]
["ENSRNOG00000015184",36,2.315895775,77,4.971263193,0.465856601,-1.102042159,{"v":8.8808e-05,"d":"8.88E-05"},{"v":6.18398e-05,"d":"6.18E-05"},"down","yes","Clic3","protein_coding","chr3:8272097-8274018:+","gi|672044646|ref|XP_008759806.1|",1416,0,"PREDICTED: chloride intracellular channel protein 3 isoform X1 [Rattus norvegicus]","gi|672044645|ref|XM_008761584.1|",1460,0,"PREDICTED: Rattus norvegicus chloride intracellular channel 3 (Clic3), transcript variant X1, mRNA","Q9D7P7",441,{"v":5e-152,"d":"5.00E-152"},"Chloride intracellular channel protein 3",".",".",".",".","pfam13409","GST_N_2","Glutathione S-transferase, N-terminal domain. This family is closely related to pfam02798.","GO:0006749|glutathione metabolic process;GO:0006821|chloride transport;GO:0034220|ion transmembrane transport;GO:0034765|regulation of ion transmembrane transport;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0016020|membrane;GO:0016604|nuclear body;GO:0034707|chloride channel complex;","GO:0005244|voltage-gated ion channel activity;GO:0005254|chloride channel activity;","K05023","CLIC3; chloride intracellular channel protein 3"]
["ENSRNOG00000039339",28,1.801252269,65,4.196520878,0.429225142,-1.22019351,{"v":9.37467e-05,"d":"9.37E-05"},{"v":6.51358e-05,"d":"6.51E-05"},"down","yes","Mslnl","protein_coding","chr10:14759311-14771675:+","gi|672024618|ref|XP_008772927.1|",3388,0,"PREDICTED: mesothelin-like protein [Rattus norvegicus]","gi|672024617|ref|XM_008774705.1|",2832,0,"PREDICTED: Rattus norvegicus mesothelin-like (Mslnl), mRNA","Q8C160",1154,0,"Mesothelin-like protein",".",".",".",".","pfam06060","Mesothelin","Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin). This family consists of several mammalian pre-pro-megakaryocyte potentiating factor precursor (MPF) or mesothelin proteins. Mesothelin is a glycosylphosphatidylinositol-linked glycoprotein highly expressed in mesothelial cells, mesotheliomas, and ovarian cancer, but the biological function of the protein is not known.","GO:0007160|cell-matrix adhesion;","GO:0009986|cell surface;GO:0016020|membrane;",".",".","."]
["ENSRNOG00000005404",21,1.350939202,54,3.486340421,0.38749492,-1.367750699,1.00163E-4,{"v":6.94673e-05,"d":"6.95E-05"},"down","yes","Rasgrp1","protein_coding","chr3:104170013-104230056:-","gi|3237381|gb|AAC40137.1|",3661,0,"ras guanyl releasing protein [Rattus norvegicus]","gi|31377529|ref|NM_019211.2|",3118,0,"Rattus norvegicus RAS guanyl releasing protein 1 (Rasgrp1), mRNA","Q9R1K8",1414,0,"RAS guanyl-releasing protein 1",".",".",".",".","pfam00617","RasGEF","RasGEF domain. Guanine nucleotide exchange factor for Ras-like small GTPases.","GO:0001934|positive regulation of protein phosphorylation;GO:0002437|inflammatory response to antigenic stimulus;GO:0007264|small GTPase mediated signal transduction;GO:0014066|regulation of phosphatidylinositol 3-kinase signaling;GO:0030101|natural killer cell activation;GO:0030154|cell differentiation;GO:0032252|secretory granule localization;GO:0032725|positive regulation of granulocyte macrophage colony-stimulating factor production;GO:0032729|positive regulation of interferon-gamma production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032816|positive regulation of natural killer cell activation;GO:0032825|positive regulation of natural killer cell differentiation;GO:0033089|positive regulation of T cell differentiation in thymus;GO:0042098|T cell proliferation;GO:0042100|B cell proliferation;GO:0042110|T cell activation;GO:0042113|B cell activation;GO:0043303|mast cell degranulation;GO:0043406|positive regulation of MAP kinase activity;GO:0043547|positive regulation of GTPase activity;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;GO:0046330|positive regulation of JNK cascade;GO:0046579|positive regulation of Ras protein signal transduction;GO:0047496|vesicle transport along microtubule;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0090630|activation of GTPase activity;","GO:0000139|Golgi membrane;GO:0005789|endoplasmic reticulum membrane;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0005509|calcium ion binding;GO:0008270|zinc ion binding;GO:0019992|diacylglycerol binding;GO:0031210|phosphatidylcholine binding;GO:0042802|identical protein binding;","K04350","RASGRP1; RAS guanyl-releasing protein 1"]
["ENSRNOG00000046772",3,0.192991315,21,1.355799053,0.142345073,-2.812535541,1.02885E-4,{"v":7.12597e-05,"d":"7.13E-05"},"down","yes","Fam83c","protein_coding","chr3:144332982-144339802:-","gi|109471157|ref|XP_001066240.1|",3504,0,"PREDICTED: protein FAM83C [Rattus norvegicus]","gi|672017614|ref|XM_001066240.5|",2587,0,"PREDICTED: Rattus norvegicus family with sequence similarity 83, member C (Fam83c), mRNA","A2ARK0",1246,0,"Protein FAM83C",".",".",".",".","pfam07894","DUF1669","Protein of unknown function (DUF1669). This family is composed of sequences derived from hypothetical eukaryotic proteins of unknown function. Some members of this family are annotated as being potential phospholipases but no literature was found to support this.","GO:0007165|signal transduction;",".","GO:0019901|protein kinase binding;","K23930","FAM83; protein FAM83"]
["ENSRNOG00000062564",3,0.192991315,21,1.355799053,0.142345073,-2.812535541,1.02885E-4,{"v":7.12597e-05,"d":"7.13E-05"},"down","yes","ENSRNOG00000062564","protein_coding","chr1:1438065-1455536:+","gi|672033848|ref|XP_006227663.2|",801,{"v":2E-100,"d":"2.00E-100"},"PREDICTED: retinoic acid early-inducible protein 1-gamma-like isoform X1 [Rattus norvegicus]","gi|672033847|ref|XM_006227601.2|",579,0,"PREDICTED: Rattus norvegicus retinoic acid early-inducible protein 1-gamma-like (LOC102547056), transcript variant X1, mRNA","B1B212",77.4,{"v":2E-14,"d":"2.00E-14"},"Histocompatibility antigen 60b",".",".",".",".","pfam14586","MHC_I_2","Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2. Members of this family are known as retinoic-acid-inducible proteins. They are ligands for the activating immunoreceptor NKG2D, which is widely expressed on natural killer cells, T cells, and macrophages.",".",".",".",".","."]
["ENSRNOG00000038894",15,0.964956573,44,2.840721825,0.339687105,-1.557721642,1.08931E-4,{"v":7.52828e-05,"d":"7.53E-05"},"down","yes","AABR07072096.1","protein_coding","chr10:31185731-31220966:+","gi|672024712|ref|XP_006220700.2|",1252,{"v":1e-164,"d":"1.00E-164"},"PREDICTED: T-cell immunoglobulin and mucin domain-containing protein 4 isoform X5 [Rattus norvegicus]","gi|672024711|ref|XM_006220638.2|",1241,0,"PREDICTED: Rattus norvegicus T-cell immunoglobulin and mucin domain containing 4 (Timd4), transcript variant X5, mRNA","Q6U7R4",207,{"v":3e-59,"d":"3.00E-59"},"T-cell immunoglobulin and mucin domain-containing protein 4",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000036837",33,2.12290446,72,4.648453895,0.456690441,-1.130711501,1.09178E-4,{"v":7.53991e-05,"d":"7.54E-05"},"down","yes","Nfe2","protein_coding","chr7:134382761-134390108:-","gi|149031876|gb|EDL86788.1|",1813,0,"rCG50844 [Rattus norvegicus]","gi|672060219|ref|XM_006242432.2|",1687,0,"PREDICTED: Rattus norvegicus nuclear factor, erythroid 2 (Nfe2), transcript variant X2, mRNA","Q6AYT2",657,0,"Transcription factor NF-E2 45 kDa subunit",".",".",".",".","pfam03131","bZIP_Maf","bZIP Maf transcription factor. Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerization and DNA binding property. Thus, this family is probably related to pfam00170. This family also includes the DNA_binding domain of Skn-1, this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0007267|cell-cell signaling;GO:0008285|negative regulation of cell proliferation;GO:0010467|gene expression;GO:0010468|regulation of gene expression;GO:0030502|negative regulation of bone mineralization;GO:0034242|negative regulation of syncytium formation by plasma membrane fusion;GO:0060716|labyrinthine layer blood vessel development;GO:2000758|positive regulation of peptidyl-lysine acetylation;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0016605|PML body;GO:0032993|protein-DNA complex;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987|proximal promoter sequence-specific DNA binding;GO:0003677|DNA binding;GO:0042802|identical protein binding;GO:0047485|protein N-terminus binding;GO:0050699|WW domain binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09039","NFE2; nuclear factor erythroid 2"]
["ENSRNOG00000006278",10,0.643304382,35,2.259665088,0.284690145,-1.812535541,1.21784E-4,{"v":8.37203e-05,"d":"8.37E-05"},"down","yes","Tspyl5","protein_coding","chr7:64884225-64885457:-","gi|564308565|ref|XP_006226118.1|",1875,0,"PREDICTED: testis-specific Y-encoded-like protein 5 [Rattus norvegicus]","gi|672021769|ref|XM_006226056.2|",1233,0,"PREDICTED: Rattus norvegicus TSPY-like 5 (Tspyl5), mRNA","Q69ZB3",626,0,"Testis-specific Y-encoded-like protein 5",".",".",".",".","pfam00956","NAP","Nucleosome assembly protein (NAP). NAP proteins are involved in moving histones into the nucleus, nucleosome assembly and chromatin fluidity. They affect the transcription of many genes.","GO:0006334|nucleosome assembly;GO:0008284|positive regulation of cell proliferation;GO:0031398|positive regulation of protein ubiquitination;GO:0051897|positive regulation of protein kinase B signaling;GO:0071480|cellular response to gamma radiation;","GO:0000785|chromatin;GO:0005634|nucleus;","GO:0003682|chromatin binding;GO:0042393|histone binding;","K11288","TSPYL5; TSPY-like 5"]
["ENSRNOG00000024221",10,0.643304382,35,2.259665088,0.284690145,-1.812535541,1.21784E-4,{"v":8.37203e-05,"d":"8.37E-05"},"down","yes","Mettl24","protein_coding","chr20:44142396-44261310:+","gi|68163513|ref|NP_001020209.1|",1628,0,"methyltransferase-like protein 24 precursor [Rattus norvegicus]","gi|68163512|ref|NM_001025038.1|",1418,0,"Rattus norvegicus methyltransferase like 24 (Mettl24), mRNA","Q5BK01",631,0,"Methyltransferase-like protein 24",".",".",".",".","pfam13383","Methyltransf_22","Methyltransferase domain. This family appears to be a methyltransferase domain.","GO:0032259|methylation;","GO:0005576|extracellular region;","GO:0008168|methyltransferase activity;",".","."]
["ENSRNOG00000005628",0,0.032165219,14,0.903866035,0.035586268,-4.812535541,1.24692E-4,{"v":8.54825E-5,"d":"8.55E-05"},"down","yes","Hoxa1","protein_coding","chr4:81255883-81258504:-","gi|827012485|ref|NP_001296293.1|",647,{"v":1e-77,"d":"1.00E-77"},"homeobox protein Hox-A1 isoform 2 [Rattus norvegicus]","gi|49457875|gb|AC122669.6|",1474,0,"Rattus norvegicus 4 BAC CH230-172C22 (Children's Hospital Oakland Research Institute) complete sequence","P09022",249,{"v":1e-74,"d":"1.00E-74"},"Homeobox protein Hox-A1",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0007399|nervous system development;GO:0007605|sensory perception of sound;GO:0007634|optokinetic behavior;GO:0008045|motor neuron axon guidance;GO:0008150|biological_process;GO:0009653|anatomical structure morphogenesis;GO:0009952|anterior/posterior pattern specification;GO:0021569|rhombomere 3 development;GO:0021570|rhombomere 4 development;GO:0021571|rhombomere 5 development;GO:0021599|abducens nerve formation;GO:0021612|facial nerve structural organization;GO:0021754|facial nucleus development;GO:0021953|central nervous system neuron differentiation;GO:0030902|hindbrain development;GO:0042472|inner ear morphogenesis;GO:0042473|outer ear morphogenesis;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048646|anatomical structure formation involved in morphogenesis;GO:0048702|embryonic neurocranium morphogenesis;GO:0048839|inner ear development;GO:0048844|artery morphogenesis;GO:0050795|regulation of behavior;GO:0050890|cognition;GO:0050905|neuromuscular process;GO:0060840|artery development;GO:0060876|semicircular canal formation;GO:0071300|cellular response to retinoic acid;GO:0071361|cellular response to ethanol;GO:0090102|cochlea development;GO:0090103|cochlea morphogenesis;","GO:0005575|cellular_component;GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0042802|identical protein binding;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09301","HOX_1; homeobox protein HoxA/B/D1"]
["ENSRNOG00000007067",0,0.032165219,14,0.903866035,0.035586268,-4.812535541,1.24692E-4,{"v":8.54825E-5,"d":"8.55E-05"},"down","yes","Padi1","protein_coding","chr5:153119566-153152034:-","gi|149024450|gb|EDL80947.1|",3390,0,"peptidyl arginine deiminase, type I [Rattus norvegicus]","gi|9506960|ref|NM_019332.1|",3713,0,"Rattus norvegicus peptidyl arginine deiminase, type I (Padi1), mRNA","O88806",1297,0,"Protein-arginine deiminase type-1",".",".",".",".","pfam03068","PAD","Protein-arginine deiminase (PAD). Members of this family are found in mammals. In the presence of calcium ions, PAD enzymes EC:3.5.3.15 catalyse the post-translational modification reaction responsible for the formation of citrulline residues: Protein L-arginine + H2O <=> Protein L-citrulline + NH3. Several types are recognized (and included in the family) on the basis of molecular mass, substrate specificity, and tissue localisation. The expression of type I PAD is known to be under the control of oestrogen.","GO:0018101|protein citrullination;GO:0036414|histone citrullination;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004668|protein-arginine deiminase activity;GO:0005509|calcium ion binding;","K01481","E3.5.3.15; protein-arginine deiminase [EC:3.5.3.15]"]
["ENSRNOG00000037149",0,0.032165219,14,0.903866035,0.035586268,-4.812535541,1.24692E-4,{"v":8.54825E-5,"d":"8.55E-05"},"down","yes","Bcl2l15","protein_coding","chr2:191338959-191344078:+","gi|157824122|ref|NP_001099929.1|",884,{"v":2e-117,"d":"2.00E-117"},"bcl-2-like protein 15 [Rattus norvegicus]","gi|157824121|ref|NM_001106459.1|",850,0,"Rattus norvegicus BCL2-like 15 (Bcl2l15), mRNA","Q08ED0",268,{"v":7e-89,"d":"7.00E-89"},"Bcl-2-like protein 15",".",".",".",".","pfam00452","Bcl-2","Apoptosis regulator proteins, Bcl-2 family.","GO:0042981|regulation of apoptotic process;","GO:0005634|nucleus;GO:0005829|cytosol;",".",".","."]
["ENSRNOG00000055581",0,0.032165219,14,0.903866035,0.035586268,-4.812535541,1.24692E-4,{"v":8.54825E-5,"d":"8.55E-05"},"down","yes","ENSRNOG00000055581","protein_coding","chr1:65671902-65679626:+","gi|672013038|ref|XP_008772621.1|",1337,0,"PREDICTED: T-cell-interacting, activating receptor on myeloid cells protein 1-like [Rattus norvegicus]","gi|672013037|ref|XM_008774399.1|",804,0,"PREDICTED: Rattus norvegicus T cell-interacting, activating receptor on myeloid cells 1 (Tarm1), mRNA","B6A8R8",415,{"v":3e-144,"d":"3.00E-144"},"T-cell-interacting, activating receptor on myeloid cells protein 1",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:1900017|positive regulation of cytokine production involved in inflammatory response;GO:2000515|negative regulation of CD4-positive, alpha-beta T cell activation;GO:2000562|negative regulation of CD4-positive, alpha-beta T cell proliferation;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0034987|immunoglobulin receptor binding;",".","."]
["ENSRNOG00000067516",0,0.032165219,14,0.903866035,0.035586268,-4.812535541,1.24692E-4,{"v":8.54825E-5,"d":"8.55E-05"},"down","yes","ENSRNOG00000067516","protein_coding","chr6:133702291-133702846:-","gi|148686571|gb|EDL18518.1|",491,{"v":7e-61,"d":"7.00E-61"},"mCG1050582, partial [Mus musculus]","gi|16307556|gb|BC010327.1|",231,{"v":5e-116,"d":"5.00E-116"},"Mus musculus Immunoglobulin heavy chain (gamma polypeptide), mRNA (cDNA clone MGC:6533 IMAGE:2651776), complete cds","P01783",187,{"v":9E-60,"d":"9.00E-60"},"Ig heavy chain V region MOPC 21 (Fragment)",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000067603",0,0.032165219,14,0.903866035,0.035586268,-4.812535541,1.24692E-4,{"v":8.54825E-5,"d":"8.55E-05"},"down","yes","ENSRNOG00000067603","IG_V_gene","chr6:133852364-133852681:-","gi|49523852|emb|CAF28442.1|",478,{"v":1E-59,"d":"1.00E-59"},"immunoglobulin heavy chain variable region [Homo sapiens]","gi|1430933|emb|Z75898.1|",257,{"v":1e-130,"d":"1.00E-130"},"R.norvegicus mRNA for immunoglobulin, gamma 1 chain, variable region (clone Hg15)","P01772",183,{"v":7e-59,"d":"7.00E-59"},"Immunoglobulin heavy variable 3-33",".",".",".",".","pfam04446","Thg1","tRNAHis guanylyltransferase. The Thg1 protein from Saccharomyces cerevisiae is responsible for adding a GMP residue to the 5' end of tRNA His. The catalytic domain Thg1 contains a RRM (ferredoxin) fold palm domain, just like the viral RNA-dependent RNA polymerases, reverse transcriptases, family A and B DNA polymerases, adenylyl cyclases, diguanylate cyclases (GGDEF domain) and the predicted polymerase of the CRISPR system. Thg1 possesses an active site with three acidic residues that chelate Mg++ cations. Thg1 catalyzes polymerization similar to the 5'-3' polymerases.",".",".",".",".","."]
["ENSRNOG00000064739",9,0.578973944,33,2.130541369,0.271749684,-1.879649737,0.000131026,{"v":8.96313e-05,"d":"8.96E-05"},"down","yes","ENSRNOG00000064739","pseudogene","chr9:111249412-111249852:-","gi|148704679|gb|EDL36626.1|",472,{"v":7e-58,"d":"7.00E-58"},"mCG7611, isoform CRA_c, partial [Mus musculus]","gi|672082766|ref|XM_003751738.3|",348,0,"PREDICTED: Rattus norvegicus 60S ribosomal protein L36a-like (LOC100912182), transcript variant X2, mRNA","P83883",169,{"v":6e-53,"d":"6.00E-53"},"60S ribosomal protein L36a","YNL162w",101,{"v":4e-27,"d":"4.00E-27"},"COG1631","pfam00935","Ribosomal_L44","Ribosomal protein L44.",".",".",".",".","."]
["ENSRNOG00000005850",5,0.321652191,25,1.614046491,0.199283102,-2.327108714,0.00013686,{"v":9.34874e-05,"d":"9.35E-05"},"down","yes","Gdap1","protein_coding","chr5:1932613-2030061:-","gi|157821895|ref|NP_001101367.1|",1830,0,"ganglioside-induced differentiation-associated protein 1 [Rattus norvegicus]","gi|157821894|ref|NM_001107897.1|",3902,0,"Rattus norvegicus ganglioside-induced differentiation-associated-protein 1 (Gdap1), mRNA","O88741",686,0,"Ganglioside-induced differentiation-associated protein 1","VC1347",52.4,3e-06,"COG0625","pfam13417","GST_N_3","Glutathione S-transferase, N-terminal domain.","GO:0000266|mitochondrial fission;GO:0006626|protein targeting to mitochondrion;GO:0006749|glutathione metabolic process;GO:0008053|mitochondrial fusion;GO:0032526|response to retinoic acid;GO:0071305|cellular response to vitamin D;","GO:0005739|mitochondrion;GO:0005829|cytosol;GO:0031307|integral component of mitochondrial outer membrane;","GO:0003674|molecular_function;","K22077","GDAP1; ganglioside-induced differentiation-associated protein 1"]
["ENSRNOG00000064184",8,0.514643505,31,2.001417649,0.257139486,-1.95937693,1.38391E-4,{"v":9.44544e-05,"d":"9.45E-05"},"down","yes","Phf11b","protein_coding","chr15:33363395-33378606:-","gi|62079205|ref|NP_001014257.1|",1344,0,"PHD finger protein 11-like [Rattus norvegicus]","gi|62079204|ref|NM_001014235.1|",1155,0,"Rattus norvegicus PHD finger protein 11B (Phf11b), mRNA","Q5I0J8",522,0,"PHD finger protein 11-like",".",".",".",".","pfam13771","zf-HC5HC2H","PHD-like zinc-binding domain. The members of this family are annotated as containing PHD domain, but the zinc-binding region here is not typical of PHD domains. The conformation here is a well-conserved cysteine-histidine rich region spanning 90 residues, where the Cys and His are arranged as HxxC(31)CxxC(6)CxxCxxxxCxxxxHxxC (21)CxxH.",".",".",".",".","."]
["ENSRNOG00000005669",16,1.029287011,45,2.905283684,0.35428107,-1.497033716,1.44225E-4,{"v":9.82719e-05,"d":"9.83E-05"},"down","yes","Ca8","protein_coding","chr5:21305383-21402374:-","gi|57527117|ref|NP_001009662.1|",1391,0,"carbonic anhydrase-related protein [Rattus norvegicus]","gi|57527116|ref|NM_001009662.1|",1399,0,"Rattus norvegicus carbonic anhydrase 8 (Car8), mRNA","Q5PPN4",540,0,"Carbonic anhydrase-related protein","BH0360",98.6,{"v":2e-22,"d":"2.00E-22"},"COG3338","pfam00194","Carb_anhydrase","Eukaryotic-type carbonic anhydrase.","GO:0006730|one-carbon metabolic process;GO:0048015|phosphatidylinositol-mediated signaling;","GO:0005737|cytoplasm;","GO:0004089|carbonate dehydratase activity;GO:0008270|zinc ion binding;GO:0016836|hydro-lyase activity;","K01672","CA; carbonic anhydrase [EC:4.2.1.1]"]
["ENSRNOG00000034184",21,1.350939202,53,3.421778562,0.394806145,-1.340783651,0.000147218,0.000100167,"down","yes","Zfp583","protein_coding","chr1:67575854-67594476:+","gi|219281893|ref|NP_001128081.2|",2850,0,"zinc finger protein 583 [Rattus norvegicus]","gi|219281892|ref|NM_001134609.2|",2550,0,"Rattus norvegicus zinc finger protein 583 (Zfp583), mRNA","Q3V080",1027,0,"Zinc finger protein 583",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006357|regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0046872|metal ion binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSRNOG00000067963",35,2.251565336,74,4.777577614,0.471277605,-1.085350968,1.4767E-4,1.00432E-4,"down","yes","ENSRNOG00000067963","lncRNA","chr17:49435384-49437561:-",".",".",".",".","gi|120953172|ref|NM_008130.2|",623,0,"Mus musculus GLI-Kruppel family member GLI3 (Gli3), mRNA",".",".",".",".",".",".",".",".","pfam14378","PAP2_3","PAP2 superfamily.",".",".",".",".","."]
["ENSRNOG00000010315",1,0.064330438,15,0.968427895,0.066427701,-3.912071215,0.000160995,1.08958E-4,"down","yes","Ccr4","protein_coding","chr8:114176974-114178056:-","gi|149018350|gb|EDL76991.1|",1740,0,"rCG25460 [Rattus norvegicus]","gi|672063364|ref|XM_006243915.2|",1083,0,"PREDICTED: Rattus norvegicus chemokine (C-C motif) receptor 4 (Ccr4), transcript variant X1, mRNA","P51680",654,0,"C-C chemokine receptor type 4",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001764|neuron migration;GO:0002507|tolerance induction;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0009314|response to radiation;GO:0009617|response to bacterium;GO:0019722|calcium-mediated signaling;GO:0046677|response to antibiotic;GO:0048872|homeostasis of number of cells;GO:0050927|positive regulation of positive chemotaxis;GO:0060326|cell chemotaxis;GO:0070098|chemokine-mediated signaling pathway;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0043025|neuronal cell body;","GO:0003674|molecular_function;GO:0016493|C-C chemokine receptor activity;GO:0019957|C-C chemokine binding;","K04179","CCR4, CD194; C-C chemokine receptor type 4"]
["ENSRNOG00000019110",1,0.064330438,15,0.968427895,0.066427701,-3.912071215,0.000160995,1.08958E-4,"down","yes","Ocstamp","protein_coding","chr3:154132328-154136991:-","gi|672017742|ref|XP_008773843.1|",2232,0,"PREDICTED: osteoclast stimulatory transmembrane protein [Rattus norvegicus]","gi|672017741|ref|XM_008775621.1|",1829,0,"PREDICTED: Rattus norvegicus zinc finger protein 334 (Zfp334), mRNA","Q9D611",729,0,"Osteoclast stimulatory transmembrane protein",".",".",".",".","pfam07782","DC_STAMP","DC-STAMP-like protein. This is a family of sequences which are similar to a region of the dendritic cell-specific transmembrane protein (DC-STAMP). This is thought to be a novel receptor protein that shares no identity with other multimembrane-spanning proteins. It is thought to have seven putative transmembrane regions, two of which are found in the region featured in this family. DC-STAMP is also described as having potential N-linked glycosylation sites and a potential phosphorylation site for PKC, but these are not conserved throughout the family.","GO:0034241|positive regulation of macrophage fusion;GO:0045672|positive regulation of osteoclast differentiation;GO:0071356|cellular response to tumor necrosis factor;GO:0071391|cellular response to estrogen stimulus;GO:0072674|multinuclear osteoclast differentiation;GO:0090290|positive regulation of osteoclast proliferation;","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000059479",1,0.064330438,15,0.968427895,0.066427701,-3.912071215,0.000160995,1.08958E-4,"down","yes","Adcy1","protein_coding","chr14:81911099-82028969:+","gi|672076819|ref|XP_008768543.1|",5183,0,"PREDICTED: adenylate cyclase type 1 isoform X2 [Rattus norvegicus]","gi|672076818|ref|XM_008770321.1|",6410,0,"PREDICTED: Rattus norvegicus adenylate cyclase 1 (brain) (Adcy1), transcript variant X2, mRNA","O88444",1975,0,"Adenylate cyclase type 1","all0661",149,{"v":4e-36,"d":"4.00E-36"},"COG2114","pfam00211","Guanylate_cyc","Adenylate and Guanylate cyclase catalytic domain.","GO:0006171|cAMP biosynthetic process;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007409|axonogenesis;GO:0007420|brain development;GO:0007616|long-term memory;GO:0007623|circadian rhythm;GO:0009410|response to xenobiotic stimulus;GO:0010226|response to lithium ion;GO:0032793|positive regulation of CREB transcription factor activity;GO:0035556|intracellular signal transduction;GO:0042752|regulation of circadian rhythm;GO:0050804|modulation of chemical synaptic transmission;GO:0150076|neuroinflammatory response;GO:1900273|positive regulation of long-term synaptic potentiation;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0014069|postsynaptic density;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098686|hippocampal mossy fiber to CA3 synapse;GO:0098978|glutamatergic synapse;GO:0099061|integral component of postsynaptic density membrane;","GO:0004016|adenylate cyclase activity;GO:0005524|ATP binding;GO:0008294|calcium- and calmodulin-responsive adenylate cyclase activity;GO:0046872|metal ion binding;","K08041","ADCY1; adenylate cyclase 1 [EC:4.6.1.1]"]
["ENSRNOG00000061595",17,1.093617449,46,2.969845544,0.368240514,-1.441279734,0.000187263,0.000126197,"down","yes","Tfec","protein_coding","chr4:45107641-45180236:-","gi|158187526|ref|NP_071774.1|",1528,0,"transcription factor EC [Rattus norvegicus]","gi|158187525|ref|NM_022379.1|",1596,0,"Rattus norvegicus transcription factor EC (Tfec), mRNA","Q63302",593,0,"Transcription factor EC",".",".",".",".","pfam11851","DUF3371","Domain of unknown function (DUF3371). This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is typically between 125 to 142 amino acids in length.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0034605|cellular response to heat;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;GO:0005654|nucleoplasm;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0046983|protein dimerization activity;GO:1990837|sequence-specific double-stranded DNA binding;","K15591","TFEC; transcription factor EC"]
["ENSRNOG00000019257",10,0.643304382,34,2.195103228,0.293063385,-1.770715366,1.93969E-4,0.000130408,"down","yes","Kif27","protein_coding","chr17:6299569-6369768:+","gi|38016129|ref|NP_932167.1|",6748,0,"kinesin-like protein KIF27 [Rattus norvegicus]","gi|38016128|ref|NM_198050.1|",4468,0,"Rattus norvegicus kinesin family member 27 (Kif27), mRNA","Q7M6Z5",2603,0,"Kinesin-like protein KIF27","YGL216w",263,{"v":2e-72,"d":"2.00E-72"},"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0003351|epithelial cilium movement;GO:0007018|microtubule-based movement;GO:0021591|ventricular system development;GO:0060271|cilium assembly;","GO:0005576|extracellular region;GO:0005737|cytoplasm;GO:0005871|kinesin complex;GO:0005874|microtubule;GO:0005929|cilium;","GO:0003777|microtubule motor activity;GO:0005524|ATP binding;GO:0008017|microtubule binding;GO:0016887|ATPase activity;","K24186","KIF27; kinesin family member 27"]
["ENSRNOG00000046482",19,1.222278326,49,3.163531123,0.386365197,-1.37196295,0.00020367,0.000136801,"down","yes","Znf750","protein_coding","chr10:106772669-106781200:-","gi|564313887|ref|XP_006221047.1|",3647,0,"PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 750 [Rattus norvegicus]","gi|672025598|ref|XM_006220985.2|",3038,0,"PREDICTED: Rattus norvegicus zinc finger protein 750 (Znf750), mRNA","Q8BH05",1240,0,"Zinc finger protein 750",".",".",".",".","pfam15269","zf-C2H2_7","Zinc-finger. this is a family of eukaryotic zinc-fingers.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0008544|epidermis development;GO:0010719|negative regulation of epithelial to mesenchymal transition;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990841|promoter-specific chromatin binding;","K24377","ZNF750; zinc finger protein 750"]
["ENSRNOG00000022957",13,0.836295696,39,2.517912527,0.332138503,-1.59014312,0.000217069,1.45425E-4,"down","yes","Ctxn3","protein_coding","chr18:50930235-50940641:+","gi|197927416|ref|NP_001128168.1|",329,{"v":1e-33,"d":"1.00E-33"},"cortexin-3 [Rattus norvegicus]","gi|197927415|ref|NM_001134696.1|",1476,0,"Rattus norvegicus cortexin 3 (Ctxn3), mRNA","Q8BXZ0",131,{"v":4E-35,"d":"4.00E-35"},"Cortexin-3",".",".",".",".","pfam11057","Cortexin","Cortexin of kidney. In the middle of cortexin protein there is a single membrane-spanning domain which indicates that this protein may be a membrane protein involved in intracellular or extracellular signalling of the kidney or brain, since it is expressed specifically in the kidneys and brain only. The protein is highly conserved among species. Cortexin is also thought to be important to neurons of both the developing and adult cerebral cortex.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000051688",16,1.029287011,44,2.840721825,0.362332912,-1.464612238,0.000217596,0.000145744,"down","yes","Syt15","protein_coding","chr16:9532478-9543281:+","gi|54607175|ref|NP_853663.2|",2142,0,"synaptotagmin-15 [Rattus norvegicus]","gi|54607174|ref|NM_181632.2|",4040,0,"Rattus norvegicus synaptotagmin 15 (Syt15), mRNA","P59926",828,0,"Synaptotagmin-15",".",".",".",".","pfam00168","C2","C2 domain.","GO:0014059|regulation of dopamine secretion;GO:0016192|vesicle-mediated transport;GO:0017156|calcium ion regulated exocytosis;GO:0017158|regulation of calcium ion-dependent exocytosis;GO:0071277|cellular response to calcium ion;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0019898|extrinsic component of membrane;GO:0070382|exocytic vesicle;","GO:0000149|SNARE binding;GO:0001786|phosphatidylserine binding;GO:0005509|calcium ion binding;GO:0005544|calcium-dependent phospholipid binding;GO:0030276|clathrin binding;","K19914","SYT15; synaptotagmin-15"]
["ENSRNOG00000050113",27,1.736921831,61,3.938273439,0.441036372,-1.181030455,0.000226363,1.51368E-4,"down","yes","AABR07030019.1","protein_coding","chr10:62308013-62308152:+","gi|74180314|dbj|BAE32328.1|",117,4e-07,"unnamed protein product [Mus musculus]","gi|672068576|ref|XM_006246905.2|",140,{"v":5e-66,"d":"5.00E-66"},"PREDICTED: Rattus norvegicus slingshot protein phosphatase 2 (Ssh2), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.",".",".",".",".","."]
["ENSRNOG00000006850",0,0.032165219,13,0.839304176,0.038323673,-4.705620337,0.000230856,0.000154011,"down","yes","Ovol2","protein_coding","chr3:131677391-131708359:-","gi|564343282|ref|XP_006235186.1|",1221,{"v":2e-162,"d":"2.00E-162"},"PREDICTED: transcription factor Ovo-like 2 isoform X1 [Rattus norvegicus]","gi|672047243|ref|XM_006235124.2|",1472,0,"PREDICTED: Rattus norvegicus ovo-like zinc finger 2 (Ovol2), transcript variant X1, mRNA","Q8CIV7",461,{"v":2e-158,"d":"2.00E-158"},"Transcription factor Ovo-like 2",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001525|angiogenesis;GO:0001755|neural crest cell migration;GO:0001842|neural fold formation;GO:0001947|heart looping;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007507|heart development;GO:0008285|negative regulation of cell proliferation;GO:0008544|epidermis development;GO:0009913|epidermal cell differentiation;GO:0009953|dorsal/ventral pattern formation;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010719|negative regulation of epithelial to mesenchymal transition;GO:0010837|regulation of keratinocyte proliferation;GO:0010944|negative regulation of transcription by competitive promoter binding;GO:0045617|negative regulation of keratinocyte differentiation;GO:0045618|positive regulation of keratinocyte differentiation;GO:0045746|negative regulation of Notch signaling pathway;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048557|embryonic digestive tract morphogenesis;GO:0051726|regulation of cell cycle;GO:0060214|endocardium formation;GO:0060347|heart trabecula formation;GO:0060390|regulation of SMAD protein signal transduction;GO:0060716|labyrinthine layer blood vessel development;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:2000647|negative regulation of stem cell proliferation;","GO:0005634|nucleus;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0046872|metal ion binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09216","OVOL; ovo"]
["ENSRNOG00000030724",0,0.032165219,13,0.839304176,0.038323673,-4.705620337,0.000230856,0.000154011,"down","yes","Adamdec1","protein_coding","chr15:42900636-42921712:-","gi|564386823|ref|XP_006252291.1|",2464,0,"PREDICTED: ADAM DEC1 isoform X1 [Rattus norvegicus]","gi|672078266|ref|XM_006252229.2|",2452,0,"PREDICTED: Rattus norvegicus ADAM-like, decysin 1 (Adamdec1), transcript variant X1, mRNA","Q9R0X2",814,0,"ADAM DEC1",".",".",".",".","pfam01421","Reprolysin","Reprolysin (M12B) family zinc metalloprotease. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as human ADAM8 and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.","GO:0006508|proteolysis;",".","GO:0004222|metalloendopeptidase activity;","K08634","ADAMDEC1; ADAM-like, decysin 1 [EC:3.4.24.-]"]
["ENSRNOG00000031523",0,0.032165219,13,0.839304176,0.038323673,-4.705620337,0.000230856,0.000154011,"down","yes","AABR07071287.1","protein_coding","chr8:100019538-100029816:+","gi|880972133|ref|XP_012982055.1|",967,{"v":3e-128,"d":"3.00E-128"},"PREDICTED: thioredoxin domain-containing protein 6, partial [Mesocricetus auratus]","gi|589924739|ref|XM_006975184.1|",396,0,"PREDICTED: Peromyscus maniculatus bairdii NME/NM23 family member 9 (Nme9), mRNA","Q86XW9",344,{"v":7e-117,"d":"7.00E-117"},"Thioredoxin domain-containing protein 6","PM1028",58.2,{"v":5e-10,"d":"5.00E-10"},"COG0105","pfam00334","NDK","Nucleoside diphosphate kinase.",".",".",".",".","."]
["ENSRNOG00000063250",0,0.032165219,13,0.839304176,0.038323673,-4.705620337,0.000230856,0.000154011,"down","yes","ENSRNOG00000063250","lncRNA","chr15:31902103-31903610:-","gi|440908179|gb|ELR58226.1|",894,{"v":2E-176,"d":"2.00E-176"},"Actin-related protein 2/3 complex subunit 1B [Bos mutus]","gi|42475955|ref|NM_019289.2|",1295,0,"Rattus norvegicus actin related protein 2/3 complex, subunit 1B (Arpc1b), mRNA","Q9WV32",361,{"v":4e-119,"d":"4.00E-119"},"Actin-related protein 2/3 complex subunit 1B",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.",".",".",".",".","."]
["ENSRNOG00000064589",0,0.032165219,13,0.839304176,0.038323673,-4.705620337,0.000230856,0.000154011,"down","yes","ENSRNOG00000064589","protein_coding","chr11:81906179-81911931:+","gi|204870|gb|AAA41420.1|",555,{"v":7e-68,"d":"7.00E-68"},"Ig lambda-chain C2-region, partial [Rattus norvegicus]","gi|672026350|ref|XM_008758339.1|",452,0,"PREDICTED: Rattus norvegicus immunoglobulin lambda-like polypeptide 5-like (LOC680329), mRNA","P20767",216,{"v":2e-68,"d":"2.00E-68"},"Ig lambda-2 chain C region",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.",".",".",".",".","."]
["ENSRNOG00000069901",0,0.032165219,13,0.839304176,0.038323673,-4.705620337,0.000230856,0.000154011,"down","yes","ENSRNOG00000069901","protein_coding","chr4:101605897-101606782:-","gi|148666393|gb|EDK98809.1|",442,{"v":1E-52,"d":"1.00E-52"},"mCG130744, partial [Mus musculus]","gi|111815141|ref|NG_005612.1|",232,{"v":2E-116,"d":"2.00E-116"},"Mus musculus immunoglobulin kappa chain complex (Igk) on chromosome 6","A2NJV5",149,{"v":1e-44,"d":"1.00E-44"},"Immunoglobulin kappa variable 2-29",".",".",".",".","pfam13927","Ig_3","Immunoglobulin domain. This family contains immunoglobulin-like domains.",".",".",".",".","."]
["ENSRNOG00000070109",0,0.032165219,13,0.839304176,0.038323673,-4.705620337,0.000230856,0.000154011,"down","yes","ENSRNOG00000070109","protein_coding","chr4:100830129-100830640:-","gi|643608|gb|AAA61986.1|",452,{"v":5e-55,"d":"5.00E-55"},"NGF-binding Ig light chain, partial [Rattus norvegicus]","gi|298898089|emb|FQ234661.1|",272,{"v":6e-139,"d":"6.00E-139"},"Rattus norvegicus TL0AEA58YC05 mRNA sequence","P01635",167,{"v":2E-52,"d":"2.00E-52"},"Ig kappa chain V-V region K2 (Fragment)",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000012110",36,2.315895775,74,4.777577614,0.48474268,-1.044708984,0.000234457,0.000156213,"down","yes","Col17a1","protein_coding","chr1:246531367-246577632:-","gi|564333963|ref|XP_006231538.1|",4296,0,"PREDICTED: collagen alpha-1(XVII) chain isoform X1 [Rattus norvegicus]","gi|672040396|ref|XM_006231476.2|",5547,0,"PREDICTED: Rattus norvegicus collagen, type XVII, alpha 1 (Col17a1), transcript variant X1, mRNA","Q07563",1323,0,"Collagen alpha-1(XVII) chain",".",".",".",".","pfam01391","Collagen","Collagen triple helix repeat (20 copies). Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxyproline. Collagens are post translationally modified by proline hydroxylase to form the hydroxyproline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure.","GO:0008150|biological_process;GO:0030198|extracellular matrix organization;GO:0031581|hemidesmosome assembly;","GO:0005575|cellular_component;GO:0005581|collagen trimer;GO:0005615|extracellular space;GO:0016021|integral component of membrane;GO:0030056|hemidesmosome;GO:0031012|extracellular matrix;","GO:0003674|molecular_function;GO:0005201|extracellular matrix structural constituent;","K07603","COL17A, BP180; collagen type XVII alpha"]
["ENSRNOG00000004564",2,0.128660876,17,1.097551614,0.117225354,-3.092643461,0.000251972,0.000167166,"down","yes","ENSRNOG00000004564","protein_coding","chr7:38192759-38409901:-","gi|755535260|ref|XP_011241897.1|",4681,0,"PREDICTED: leucine-rich repeat and IQ domain-containing protein 1 isoform X6 [Mus musculus]","gi|672021610|ref|XM_008776430.1|",3434,0,"PREDICTED: Rattus norvegicus leucine-rich repeats and IQ motif containing 1 (Lrriq1), mRNA",".",".",".",".","lin0372",63.5,6E-9,"COG4886","pfam12799","LRR_4","Leucine Rich repeats (2 copies). Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.",".",".",".",".","."]
["ENSRNOG00000027655",2,0.128660876,17,1.097551614,0.117225354,-3.092643461,0.000251972,0.000167166,"down","yes","Clec4b2","protein_coding","chr4:156462742-156486240:+","gi|54312118|ref|NP_001005896.1|",1115,{"v":1e-152,"d":"1.00E-152"},"C-type lectin domain family 4 member C [Rattus norvegicus]","gi|54312117|ref|NM_001005896.1|",697,0,"Rattus norvegicus C-type lectin domain family 4, member B2 (Clec4b2), mRNA","Q9JKF4",263,{"v":6e-87,"d":"6.00E-87"},"C-type lectin domain family 6 member A",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;","GO:0016021|integral component of membrane;","GO:0030246|carbohydrate binding;","K17514","CLEC6A, DECTIN2; C-type lectin domain family 6 member A"]
["ENSRNOG00000066925",2,0.128660876,17,1.097551614,0.117225354,-3.092643461,0.000251972,0.000167166,"down","yes","ENSRNOG00000066925","protein_coding","chr1:76947868-76948375:+","gi|944460819|gb|KQL97919.1|",217,{"v":1e-20,"d":"1.00E-20"},"dynein light chain 1, cytoplasmic-like protein [Alligator mississippiensis]","gi|402747029|ref|NM_053319.3|",119,{"v":4e-54,"d":"4.00E-54"},"Rattus norvegicus dynein light chain LC8-type 1 (Dynll1), mRNA","P63170",86.3,{"v":7e-22,"d":"7.00E-22"},"Dynein light chain 1, cytoplasmic",".",".",".",".","pfam01221","Dynein_light","Dynein light chain type 1.",".",".",".",".","."]
["ENSRNOG00000025254",11,0.70763482,35,2.259665088,0.31315916,-1.675032018,0.000276226,1.82404E-4,"down","yes","Qrich2","protein_coding","chr10:101669224-101697656:-","gi|672025500|ref|XP_008773826.1|",12104,0,"PREDICTED: glutamine-rich protein 2 isoform X7 [Rattus norvegicus]","gi|672025499|ref|XM_008775604.1|",5012,0,"PREDICTED: Rattus norvegicus glutamine rich 2 (Qrich2), transcript variant X7, mRNA",".",".",".",".","Rv0304c",144,{"v":3e-33,"d":"3.00E-33"},"COG5651","pfam03157","Glutenin_hmw","High molecular weight glutenin subunit. Members of this family include high molecular weight subunits of glutenin. This group of gluten proteins is thought to be largely responsible for the elastic properties of gluten, and hence, doughs. Indeed, glutenin high molecular weight subunits are classified as elastomeric proteins, because the glutenin network can withstand significant deformations without breaking, and return to the original conformation when the stress is removed. Elastomeric proteins differ considerably in amino acid sequence, but they are all polymers whose subunits consist of elastomeric domains, composed of repeated motifs, and non-elastic domains that mediate cross-linking between the subunits. The elastomeric domain motifs are all rich in glycine residues in addition to other hydrophobic residues. High molecular weight glutenin subunits have an extensive central elastomeric domain, flanked by two terminal non-elastic domains that form disulphide cross-links. The central elastomeric domain is characterized by the following three repeated motifs: PGQGQQ, GYYPTS[P/L]QQ, GQQ. It possesses overlapping beta-turns within and between the repeated motifs, and assumes a regular helical secondary structure with a diameter of approx. 1.9 nm and a pitch of approx. 1.5 nm.","GO:0030031|cell projection assembly;GO:0030317|flagellated sperm motility;GO:2000059|negative regulation of ubiquitin-dependent protein catabolic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0036126|sperm flagellum;",".","K24298","QRICH2; glutamine-rich protein 2"]
["ENSRNOG00000020054",35,2.251565336,72,4.648453895,0.48436865,-1.045822604,2.81472E-4,1.85761E-4,"down","yes","ENSRNOG00000020054","protein_coding","chr18:29181052-29183804:+","gi|293354902|ref|XP_001055818.2|",4047,0,"PREDICTED: protocadherin beta-7 isoform X2 [Rattus norvegicus]","gi|672083180|ref|XM_001055818.5|",2753,0,"PREDICTED: Rattus norvegicus similar to protocadherin beta 16 (LOC690826), transcript variant X2, mRNA","Q9Y5E2",1187,0,"Protocadherin beta-7",".",".",".",".","pfam08266","Cadherin_2","Cadherin-like. This cadherin domain is usually the most N-terminal copy of the domain.","GO:0007155|cell adhesion;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;","GO:0005887|integral component of plasma membrane;","GO:0005509|calcium ion binding;","K16494","PCDHB; protocadherin beta"]
["ENSRNOG00000004678",1,0.064330438,14,0.903866035,0.071172536,-3.812535541,3.00845E-4,1.97815E-4,"down","yes","Itln1","protein_coding","chr13:83948124-83958227:+","gi|149040701|gb|EDL94658.1|",1695,0,"similar to intelectin [Rattus norvegicus]","gi|77917589|ref|NM_001034946.1|",1061,0,"Rattus norvegicus intelectin 1 (galactofuranose binding) (Itln1), mRNA","O88310",585,0,"Intelectin-1a",".",".",".",".","pfam00147","Fibrinogen_C","Fibrinogen beta and gamma chains, C-terminal globular domain.","GO:0001934|positive regulation of protein phosphorylation;GO:0009624|response to nematode;GO:0046326|positive regulation of glucose import;GO:0070207|protein homotrimerization;","GO:0005615|extracellular space;GO:0031526|brush border membrane;GO:0043235|receptor complex;GO:0045121|membrane raft;","GO:0005509|calcium ion binding;GO:0042802|identical protein binding;GO:0070492|oligosaccharide binding;","K17527","ITLN; intelectin"]
["ENSRNOG00000036647",1,0.064330438,14,0.903866035,0.071172536,-3.812535541,3.00845E-4,1.97815E-4,"down","yes","Olr292","protein_coding","chr1:195039123-195136263:+","gi|392344724|ref|XP_002728864.2|",5010,0,"PREDICTED: scavenger receptor cysteine-rich domain-containing protein SCART1-like isoform X2 [Rattus norvegicus]","gi|672038995|ref|XM_002728818.4|",3268,0,"PREDICTED: Rattus norvegicus similar to scavenger receptor cysteine-rich type 1 protein M160 precursor (LOC680907), transcript variant X2, mRNA","Q4G0T1",826,0,"Scavenger receptor cysteine-rich domain-containing protein SCART1",".",".",".",".","pfam00530","SRCR","Scavenger receptor cysteine-rich domain. These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.","GO:0002365|gamma-delta T cell lineage commitment;GO:0006897|endocytosis;GO:0007186|G protein-coupled receptor signaling pathway;GO:0050911|detection of chemical stimulus involved in sensory perception of smell;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004984|olfactory receptor activity;GO:0005044|scavenger receptor activity;GO:0005549|odorant binding;","K04257","OLFR; olfactory receptor"]
["ENSRNOG00000063443",10,0.643304382,33,2.130541369,0.301944093,-1.727646644,0.000307305,0.000201853,"down","yes","Pirt","protein_coding","chr10:51613126-51632264:+","gi|157817392|ref|NP_001102502.1|",655,{"v":3e-75,"d":"3.00E-75"},"phosphoinositide-interacting protein [Rattus norvegicus]","gi|755537768|ref|XM_006532579.2|",1387,0,"PREDICTED: Mus musculus phosphoinositide-interacting regulator of transient receptor potential channels (Pirt), transcript variant X2, mRNA","Q8BFY0",241,{"v":3e-71,"d":"3.00E-71"},"Phosphoinositide-interacting protein",".",".",".",".","pfam15099","PIRT","Phosphoinositide-interacting protein family. The function of this family, PIRT, is not known, however it is predicted to be a multi-pass membrane protein. This family of proteins is thought to have a role in positively regulating TRPV1 channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2). This family of proteins is found in eukaryotes. Proteins in this family are located in the cell membrane. Proteins in this family are approximately 140 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000000842",23,1.479600078,54,3.486340421,0.424399198,-1.236506165,0.00032091,0.000210186,"down","yes","Ddah2","protein_coding","chr20:3761465-3764511:-","gi|537254028|gb|ERE88825.1|",1194,{"v":6e-159,"d":"6.00E-159"},"N(G),N(G)-dimethylarginine dimethylaminohydrolase 2-like isoform 1 [Cricetulus griseus]","gi|672085608|ref|XM_008772714.1|",1338,0,"PREDICTED: Rattus norvegicus dimethylarginine dimethylaminohydrolase 2 (Ddah2), transcript variant X1, mRNA","Q6MG60",457,{"v":9e-159,"d":"9.00E-159"},"N(G),N(G)-dimethylarginine dimethylaminohydrolase 2",".",".",".",".","pfam02274","Amidinotransf","Amidinotransferase. This family contains glycine (EC:2.1.4.1) and inosamine (EC:2.1.4.2) amidinotransferases, enzymes involved in creatine and streptomycin biosynthesis respectively. This family also includes arginine deiminases, EC:3.5.3.6. These enzymes catalyse the reaction: arginine + H2O <=> citrulline + NH3. Also found in this family is the Streptococcus anti tumor glycoprotein.","GO:0000052|citrulline metabolic process;GO:0006525|arginine metabolic process;GO:0006527|arginine catabolic process;GO:0045429|positive regulation of nitric oxide biosynthetic process;","GO:0005739|mitochondrion;","GO:0016403|dimethylargininase activity;GO:0016597|amino acid binding;","K01482","DDAH, ddaH; dimethylargininase [EC:3.5.3.18]"]
["ENSRNOG00000004221",8,0.514643505,29,1.87229393,0.274873244,-1.863161614,0.000365293,2.37593E-4,"down","yes","Lgr5","protein_coding","chr7:51088239-51222446:-","gi|157817525|ref|NP_001100254.1|",4231,0,"leucine-rich repeat-containing G-protein coupled receptor 5 precursor [Rattus norvegicus]","gi|157817524|ref|NM_001106784.1|",3130,0,"Rattus norvegicus leucine rich repeat containing G protein coupled receptor 5 (Lgr5), mRNA","D4AC13",1634,0,"Leucine-rich repeat-containing G-protein coupled receptor 5","alr0124_1",104,{"v":2e-22,"d":"2.00E-22"},"COG4886","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001942|hair follicle development;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007190|activation of adenylate cyclase activity;GO:0008150|biological_process;GO:0009755|hormone-mediated signaling pathway;GO:0009994|oocyte differentiation;GO:0042127|regulation of cell proliferation;GO:0048839|inner ear development;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:2001013|epithelial cell proliferation involved in renal tubule morphogenesis;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005794|Golgi apparatus;GO:0005887|integral component of plasma membrane;GO:0032588|trans-Golgi network membrane;","GO:0003674|molecular_function;GO:0004888|transmembrane signaling receptor activity;GO:0008528|G protein-coupled peptide receptor activity;GO:0016500|protein-hormone receptor activity;","K04308","LGR5, GPR49; leucine-rich repeat-containing G protein-coupled receptor 5"]
["ENSRNOG00000015101",8,0.514643505,29,1.87229393,0.274873244,-1.863161614,0.000365293,2.37593E-4,"down","yes","Mak","protein_coding","chr17:23693878-23730001:+","gi|380865394|sp|P20793.2|MAK_RAT",3188,0,"RecName: Full=Serine/threonine-protein kinase MAK; AltName: Full=Male germ cell-associated kinase","gi|755544685|ref|XM_006516868.2|",1851,0,"PREDICTED: Mus musculus male germ cell-associated kinase (Mak), transcript variant X1, mRNA","P20793",1232,0,"Serine/threonine-protein kinase MAK",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006468|protein phosphorylation;GO:0007283|spermatogenesis;GO:0030154|cell differentiation;GO:0035556|intracellular signal transduction;GO:0042073|intraciliary transport;GO:0045494|photoreceptor cell maintenance;GO:0045893|positive regulation of transcription, DNA-templated;GO:0046777|protein autophosphorylation;GO:0060271|cilium assembly;GO:1902856|negative regulation of non-motile cilium assembly;","GO:0001750|photoreceptor outer segment;GO:0001917|photoreceptor inner segment;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0005929|cilium;GO:0005930|axoneme;GO:0030496|midbody;GO:0031514|motile cilium;GO:0032391|photoreceptor connecting cilium;GO:0072686|mitotic spindle;GO:0097542|ciliary tip;","GO:0003713|transcription coactivator activity;GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;GO:0046872|metal ion binding;","K08829","MAK; male germ cell-associated kinase [EC:2.7.11.22]"]
["ENSRNOG00000068755",4,0.257321753,21,1.355799053,0.18979343,-2.397498042,0.00037447,0.000243201,"down","yes","ENSRNOG00000068755","lncRNA","chr8:58049228-58051547:+","gi|149033621|gb|EDL88419.1|",132,6e-07,"rCG61286, isoform CRA_a [Rattus norvegicus]","gi|47777566|gb|AC122528.3|",297,{"v":3E-152,"d":"3.00E-152"},"Mus musculus BAC clone RP24-506F15 from chromosome 9, complete sequence",".",".",".",".",".",".",".",".","pfam09508","Lact_bio_phlase","Lacto-N-biose phosphorylase. The gene which codes for this protein in gut-bacteria is located in a novel putative operon for galactose metabolizm. The protein appears to be a carbohydrate-processing phosphorolytic enzyme (EC:2.4.1.211), unlike either glycoside hydrolases or glycoside lyase. Intestinal colonisation by bifidobacteria is important for human health, especially in pediatrics, because colonisation seems to prevent infection by some pathogenic bacteria that cause diarrhoea or other illnesses. The operon seems to be involved in intestinal colonisation by bifidobacteria mediated by metabolizm of mucin sugars. In addition, it may also resolve the question of the nature of the bifidus factor in human milk as the lacto-N-biose structure found in milk oligosaccharides.",".",".",".",".","."]
["ENSRNOG00000017193",22,1.41526964,52,3.357216702,0.421560407,-1.246188719,3.81975E-4,0.000247963,"down","yes","Lingo1","protein_coding","chr8:57010007-57196544:-","gi|213688408|ref|NP_001094192.1|",3045,0,"leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 precursor [Rattus norvegicus]","gi|672062025|ref|XM_008766270.1|",3129,0,"PREDICTED: Rattus norvegicus leucine rich repeat and Ig domain containing 1 (Lingo1), transcript variant X1, mRNA","Q96FE5",1167,0,"Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1","alr0124_1",66.2,{"v":8e-10,"d":"8.00E-10"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0021954|central nervous system neuron development;GO:0031175|neuron projection development;GO:0043491|protein kinase B signaling;GO:0048715|negative regulation of oligodendrocyte differentiation;","GO:0005615|extracellular space;GO:0016021|integral component of membrane;GO:0031012|extracellular matrix;","GO:0005154|epidermal growth factor receptor binding;","K23533","LINGO, LRRN6; leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein"]
["ENSRNOG00000054314",5,0.321652191,23,1.484922772,0.216612067,-2.206814481,3.97072E-4,0.000257325,"down","yes","Kcng1","protein_coding","chr3:156973156-156992635:-","gi|157818435|ref|NP_001100015.1|",2402,0,"potassium voltage-gated channel subfamily G member 1 [Rattus norvegicus]","gi|157818434|ref|NM_001106545.1|",2745,0,"Rattus norvegicus potassium voltage-gated channel modifier subfamily G member 1 (Kcng1), mRNA","D4AD53",929,0,"Potassium voltage-gated channel subfamily G member 1","MA2034",69.3,{"v":6e-12,"d":"6.00E-12"},"COG1226","pfam02214","BTB_2","BTB/POZ domain. In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.","GO:0006813|potassium ion transport;GO:0051260|protein homooligomerization;GO:0071805|potassium ion transmembrane transport;GO:1902259|regulation of delayed rectifier potassium channel activity;","GO:0005886|plasma membrane;GO:0008076|voltage-gated potassium channel complex;GO:0016021|integral component of membrane;","GO:0005249|voltage-gated potassium channel activity;GO:0005251|delayed rectifier potassium channel activity;","K04900","KCNG1, KV6.1; potassium voltage-gated channel subfamily G member 1"]
["ENSRNOG00000017922",6,0.385982629,25,1.614046491,0.239139722,-2.064074308,0.000399437,0.00025874,"down","yes","Tpbgl","protein_coding","chr1:153925098-153926252:-","gi|392337830|ref|XP_003753369.1|",1507,0,"PREDICTED: trophoblast glycoprotein-like [Rattus norvegicus]","gi|672014067|ref|XM_003753321.3|",1155,0,"PREDICTED: Rattus norvegicus trophoblast glycoprotein-like (Tpbgl), mRNA","Q8C013",526,0,"Trophoblast glycoprotein-like",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.","GO:0090090|negative regulation of canonical Wnt signaling pathway;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000011181",0,0.032165219,12,0.774742316,0.041517313,-4.59014312,0.000429806,2.77154E-4,"down","yes","Cpa3","protein_coding","chr2:102712589-102744203:-","gi|213512704|ref|NP_062173.1|",2256,0,"mast cell carboxypeptidase A precursor [Rattus norvegicus]","gi|213512703|ref|NM_019300.1|",1427,0,"Rattus norvegicus carboxypeptidase A3 (Cpa3), mRNA","P21961",863,0,"Mast cell carboxypeptidase A (Fragment)","YHR132c",186,{"v":5E-52,"d":"5.00E-52"},"COG2866","pfam00246","Peptidase_M14","Zinc carboxypeptidase.","GO:0002002|regulation of angiotensin levels in blood;GO:0006508|proteolysis;","GO:0005615|extracellular space;GO:0030133|transport vesicle;","GO:0004181|metallocarboxypeptidase activity;GO:0008233|peptidase activity;GO:0008270|zinc ion binding;","K08780","CPA3; carboxypeptidase A3 [EC:3.4.17.1]"]
["ENSRNOG00000011460",0,0.032165219,12,0.774742316,0.041517313,-4.59014312,0.000429806,2.77154E-4,"down","yes","Arfgef3","protein_coding","chr1:13244830-13404084:-","gi|109460492|ref|XP_001072524.1|",10715,0,"PREDICTED: brefeldin A-inhibited guanine nucleotide-exchange protein 3 isoform X1 [Rattus norvegicus]","gi|672012479|ref|XM_001072524.5|",8054,0,"PREDICTED: Rattus norvegicus similar to mKIAA1244 protein (RGD1309903), transcript variant X1, mRNA","Q3UGY8",4004,0,"Brefeldin A-inhibited guanine nucleotide-exchange protein 3",".",".",".",".","pfam09324","DUF1981","Domain of unknown function (DUF1981). Members of this family of functionally uncharacterized domains are found in various plant and yeast protein transport proteins.","GO:0030036|actin cytoskeleton organization;GO:0032012|regulation of ARF protein signal transduction;GO:0050790|regulation of catalytic activity;",".","GO:0005085|guanyl-nucleotide exchange factor activity;","K17572","ARFGEF3, KEPI; brefeldin A-inhibited guanine nucleotide-exchange protein 3"]
["ENSRNOG00000042860",0,0.032165219,12,0.774742316,0.041517313,-4.59014312,0.000429806,2.77154E-4,"down","yes","Pappa2","protein_coding","chr13:70876794-71147779:-","gi|392352768|ref|XP_002728071.2|",9465,0,"PREDICTED: pappalysin-2 [Rattus norvegicus]","gi|672074611|ref|XM_002728025.4|",6179,0,"PREDICTED: Rattus norvegicus similar to pappalysin 2 isoform 1 (LOC680415), transcript variant X2, mRNA","Q9BXP8",2900,0,"Pappalysin-2",".",".",".",".","pfam13385","Laminin_G_3","Concanavalin A-like lectin/glucanases superfamily. This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.","GO:0006508|proteolysis;GO:0009651|response to salt stress;GO:0060349|bone morphogenesis;","GO:0005829|cytosol;GO:0016324|apical plasma membrane;","GO:0004222|metalloendopeptidase activity;GO:0008237|metallopeptidase activity;GO:0008270|zinc ion binding;","K08647","PAPPA2; pappalysin-2 [EC:3.4.24.-]"]
["ENSRNOG00000058590",0,0.032165219,12,0.774742316,0.041517313,-4.59014312,0.000429806,2.77154E-4,"down","yes","ENSRNOG00000058590","protein_coding","chr11:81947934-81949822:+","gi|564314743|ref|XP_006221276.1|",644,{"v":3e-82,"d":"3.00E-82"},"PREDICTED: Ig lambda-1 chain C region-like isoform X2 [Rattus norvegicus]","gi|672071809|ref|XM_008768911.1|",752,0,"PREDICTED: Rattus norvegicus lambda-chain C1-region-like (LOC100361706), transcript variant X2, mRNA","P20766",216,{"v":7e-70,"d":"7.00E-70"},"Ig lambda-1 chain C region",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.",".",".",".",".","."]
["ENSRNOG00000063488",0,0.032165219,12,0.774742316,0.041517313,-4.59014312,0.000429806,2.77154E-4,"down","yes","ENSRNOG00000063488","lncRNA","chr5:147637202-147644528:+","gi|148701761|gb|EDL33708.1|",168,{"v":4e-12,"d":"4.00E-12"},"mCG148147 [Mus musculus]","gi|21211937|emb|AL627185.10|",306,{"v":2e-157,"d":"2.00E-157"},"Mouse DNA sequence from clone RP23-332E2 on chromosome 4, complete sequence",".",".",".",".",".",".",".",".","pfam15384","DUF4610","Domain of unknown function (DUF4610). This family of proteins is found in eukaryotes. Proteins in this family are typically between 164 and 206 amino acids in length. There is a conserved NPG sequence motif.",".",".",".",".","."]
["ENSRNOG00000064052",0,0.032165219,12,0.774742316,0.041517313,-4.59014312,0.000429806,2.77154E-4,"down","yes","Kcna1","protein_coding","chr4:159464188-159472682:-","gi|27465523|ref|NP_775118.1|",2256,0,"potassium voltage-gated channel subfamily A member 1 [Rattus norvegicus]","gi|119395751|ref|NM_010595.3|",5891,0,"Mus musculus potassium voltage-gated channel, shaker-related subfamily, member 1 (Kcna1), mRNA","P10499",873,0,"Potassium voltage-gated channel subfamily A member 1","MA2034",66.6,{"v":1E-10,"d":"1.00E-10"},"COG1226","pfam02214","BTB_2","BTB/POZ domain. In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.",".",".",".",".","."]
["ENSRNOG00000070810",0,0.032165219,12,0.774742316,0.041517313,-4.59014312,0.000429806,2.77154E-4,"down","yes","ENSRNOG00000070810","protein_coding","chr4:98893809-98894347:-","gi|149037316|gb|EDL91791.1|",480,{"v":2e-59,"d":"2.00E-59"},"rCG53367, partial [Rattus norvegicus]","gi|298909659|emb|FQ232394.1|",365,0,"Rattus norvegicus TL0AEA65YO13 mRNA sequence","A0A075B6S5",134,{"v":2e-39,"d":"2.00E-39"},"Immunoglobulin kappa variable 1-27",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000038197",2,0.128660876,16,1.032989754,0.124551938,-3.005180619,4.59648E-4,0.00029563,"down","yes","Cd226","protein_coding","chr18:82450568-82543051:+","gi|157817173|ref|NP_001100840.1|",1734,0,"CD226 antigen precursor [Rattus norvegicus]","gi|157817172|ref|NM_001107370.1|",2312,0,"Rattus norvegicus CD226 molecule (Cd226), mRNA","Q8K4F0",552,0,"CD226 antigen",".",".",".",".","pfam10565","NMDAR2_C","N-methyl D-aspartate receptor 2B3 C-terminus. This domain is found at the C-terminus of many NMDA-receptor proteins, many of which also carry the Ligated ion-channel family pfam00060 further upstream as well as the ANF_receptor family pfam01094. This region is predicted to be a large extra-cellular domain of the NMDA receptor proteins, being highly hydrophilic, and is thought to be integrally involved in the function of the receptor. The region also carries a number of potential N-glycosylation sites.","GO:0001816|cytokine production;GO:0002729|positive regulation of natural killer cell cytokine production;GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target;GO:0002891|positive regulation of immunoglobulin mediated immune response;GO:0008150|biological_process;GO:0032729|positive regulation of interferon-gamma production;GO:0033005|positive regulation of mast cell activation;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;GO:0050862|positive regulation of T cell receptor signaling pathway;GO:0060369|positive regulation of Fc receptor mediated stimulatory signaling pathway;","GO:0005575|cellular_component;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0005178|integrin binding;GO:0019901|protein kinase binding;GO:0050839|cell adhesion molecule binding;","K06567","CD226, DNAM1; CD226 antigen"]
["ENSRNOG00000010406",10,0.643304382,32,2.065979509,0.311379846,-1.683252524,0.000484149,0.000310479,"down","yes","Cel","protein_coding","chr3:11883532-11891035:-","gi|302058302|ref|NP_058693.2|",3170,0,"bile salt-activated lipase precursor [Rattus norvegicus]","gi|302058301|ref|NM_016997.2|",2062,0,"Rattus norvegicus carboxyl ester lipase (Cel), mRNA","P07882",1210,0,"Bile salt-activated lipase","BS_pnbA",189,{"v":1E-51,"d":"1.00E-51"},"COG2272","pfam00135","COesterase","Carboxylesterase family.","GO:0006707|cholesterol catabolic process;GO:0007158|neuron cell-cell adhesion;GO:0007268|chemical synaptic transmission;GO:0008150|biological_process;GO:0030157|pancreatic juice secretion;GO:0042572|retinol metabolic process;GO:0046514|ceramide catabolic process;GO:0048488|synaptic vesicle endocytosis;GO:0050804|modulation of chemical synaptic transmission;GO:0097104|postsynaptic membrane assembly;GO:0097105|presynaptic membrane assembly;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005791|rough endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0032991|protein-containing complex;GO:0042588|zymogen granule;GO:0043231|intracellular membrane-bounded organelle;GO:0045121|membrane raft;GO:0045202|synapse;GO:0098793|presynapse;GO:0099060|integral component of postsynaptic specialization membrane;","GO:0004622|lysophospholipase activity;GO:0004771|sterol esterase activity;GO:0004806|triglyceride lipase activity;GO:0008126|acetylesterase activity;GO:0016788|hydrolase activity, acting on ester bonds;GO:0038023|signaling receptor activity;GO:0042043|neurexin family protein binding;GO:0043208|glycosphingolipid binding;GO:0044877|protein-containing complex binding;GO:0050253|retinyl-palmitate esterase activity;GO:0052689|carboxylic ester hydrolase activity;","K12298","CEL; bile salt-stimulated lipase [EC:3.1.1.3 3.1.1.13]"]
["ENSRNOG00000014953",10,0.643304382,32,2.065979509,0.311379846,-1.683252524,0.000484149,0.000310479,"down","yes","Fbxo39","protein_coding","chr10:56932297-56934906:+","gi|537143087|gb|ERE68820.1|",2410,0,"F-box only protein 39 [Cricetulus griseus]","gi|672067930|ref|XM_006246729.2|",1591,0,"PREDICTED: Rattus norvegicus F-box protein 39 (Fbxo39), transcript variant X2, mRNA","Q66H10",919,0,"F-box only protein 39",".",".",".",".","pfam12937","F-box-like","F-box-like. This is an F-box-like family.","GO:0031146|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;","GO:0019005|SCF ubiquitin ligase complex;",".","K10314","FBXO39; F-box protein 39"]
["ENSRNOG00000001869",18,1.157947887,45,2.905283684,0.398566203,-1.327108714,0.000520311,0.000332512,"down","yes","Rab44","protein_coding","chr20:7164720-7198468:+","gi|564321855|ref|XP_006223885.1|",4726,0,"PREDICTED: ras-related protein Rab-44 [Rattus norvegicus]","gi|672031553|ref|XM_006223823.2|",3590,0,"PREDICTED: Rattus norvegicus RAB44, member RAS oncogene family (Rab44), mRNA","Q8CB87",1501,0,"Ras-related protein Rab-44",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.",".",".","GO:0003924|GTPase activity;GO:0005525|GTP binding;",".","."]
["ENSRNOG00000069610",35,2.251565336,70,4.519330176,0.498207754,-1.005180619,0.000527972,0.00033716,"down","yes","ENSRNOG00000069610","lncRNA","chr6:130965889-130967437:-","gi|67078514|ref|NP_001019920.1|",568,{"v":2e-67,"d":"2.00E-67"},"UPF0235 protein C15orf40 homolog [Rattus norvegicus]","gi|672021182|ref|XM_003754243.3|",1196,0,"PREDICTED: Rattus norvegicus hypothetical protein LOC100363116 (LOC100363116), mRNA","Q505I4",223,{"v":7e-69,"d":"7.00E-69"},"UPF0235 protein C15orf40 homolog","VC0458",57.4,4e-09,"COG1872","pfam02594","DUF167","Uncharacterized ACR, YggU family COG1872.",".",".",".",".","."]
["ENSRNOG00000036877",1,0.064330438,13,0.839304176,0.076647347,-3.705620337,0.000563256,0.000358352,"down","yes","Clca4l","protein_coding","chr2:233826133-233846716:-","gi|149026142|gb|EDL82385.1|",4546,0,"rCG29121 [Rattus norvegicus]","gi|402691649|ref|NM_001077356.2|",2876,0,"Rattus norvegicus chloride channel calcium activated 4-like (Clca4l), mRNA","Q9QX15",1354,0,"Calcium-activated chloride channel regulator 3A-1","sll0103",53.9,2e-06,"COG2304","pfam08434","CLCA_N","Calcium-activated chloride channel. The CLCA family of calcium-activated chloride channels has been identified in many epithelial and endothelial cell types as well as in smooth muscle cells and has four or five putative transmembrane regions. Additionally to their role as chloride channels some CLCA proteins function as adhesion molecules and may also have roles as tumor suppressors. The domain described here is found at the N-terminus of CLCAs.","GO:0006508|proteolysis;GO:0006821|chloride transport;","GO:0005887|integral component of plasma membrane;","GO:0005229|intracellular calcium activated chloride channel activity;GO:0008237|metallopeptidase activity;GO:0046872|metal ion binding;","K05030","CLCA3_4; calcium-activated chloride channel regulator 3/4"]
["ENSRNOG00000053071",1,0.064330438,13,0.839304176,0.076647347,-3.705620337,0.000563256,0.000358352,"down","yes","SNORA70","snoRNA","chr5:115961775-115961902:+",".",".",".",".","gi|21621612|emb|AL645668.15|",43,{"v":4e-12,"d":"4.00E-12"},"Mouse DNA sequence from clone RP23-32L21 on chromosome 4, complete sequence",".",".",".",".",".",".",".",".","pfam01314","AFOR_C","Aldehyde ferredoxin oxidoreductase, domains 2 & 3. Aldehyde ferredoxin oxidoreductase (AOR) catalyses the reversible oxidation of aldehydes to their corresponding carboxylic acids with their accompanying reduction of the redox protein ferredoxin. This family is composed of two structural domains that bind the tungsten cofactor via DXXGL(C/D) motifs. In addition to maintaining specific binding interactions with the cofactor, another role for domains 2 and 3 may be to regulate substrate access to AOR.",".",".",".",".","."]
["ENSRNOG00000069640",1,0.064330438,13,0.839304176,0.076647347,-3.705620337,0.000563256,0.000358352,"down","yes","ENSRNOG00000069640","protein_coding","chr6:92987935-93000283:+","gi|148704546|gb|EDL36493.1|",872,{"v":2e-111,"d":"2.00E-111"},"mCG146312, partial [Mus musculus]","gi|672020833|ref|XR_601488.1|",897,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102551114 (LOC102551114), ncRNA",".",".",".",".",".",".",".",".","pfam06031","SERTA","SERTA motif. This family consists of a novel motif designated as SERTA (for SEI-1, RBT1, and TARA), corresponding to the largest conserved region among TRIP-Br proteins. The function of this motif is uncertain, but the CDK4-interacting segment of p34SEI-1 (amino acid residues 44-161) includes most of the SERTA motif.",".",".",".",".","."]
["ENSRNOG00000016828",3,0.192991315,18,1.162113474,0.166069251,-2.59014312,0.000578747,0.000367716,"down","yes","Cmtm5","protein_coding","chr15:28412624-28415287:+","gi|149063936|gb|EDM14206.1|",562,{"v":5e-68,"d":"5.00E-68"},"chemokine-like factor super family 5 (predicted), isoform CRA_a [Rattus norvegicus]","gi|399498562|ref|NM_001106034.2|",616,0,"Rattus norvegicus CKLF-like MARVEL transmembrane domain containing 5 (Cmtm5), mRNA","Q96DZ9",200,{"v":3e-60,"d":"3.00E-60"},"CKLF-like MARVEL transmembrane domain-containing protein 5",".",".",".",".","pfam01284","MARVEL","Membrane-associating domain. MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.","GO:0045662|negative regulation of myoblast differentiation;","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000057315",3,0.192991315,18,1.162113474,0.166069251,-2.59014312,0.000578747,0.000367716,"down","yes","Kcnh3","protein_coding","chr7:130366011-130383855:+","gi|8659557|ref|NP_058804.1|",4817,0,"potassium voltage-gated channel subfamily H member 3 [Rattus norvegicus]","gi|8659556|ref|NM_017108.1|",3703,0,"Rattus norvegicus potassium voltage-gated channel subfamily H member 3 (Kcnh3), mRNA","O89047",1860,0,"Potassium voltage-gated channel subfamily H member 3","CC0285_1",85.1,{"v":6e-17,"d":"6.00E-17"},"COG2202","pfam13426","PAS_9","PAS domain.","GO:0034765|regulation of ion transmembrane transport;GO:0042391|regulation of membrane potential;GO:0071805|potassium ion transmembrane transport;","GO:0005887|integral component of plasma membrane;","GO:0005249|voltage-gated potassium channel activity;","K04906","KCNH3, KV12.2; potassium voltage-gated channel Eag-related subfamily H member 3"]
["ENSRNOG00000020066",12,0.771965258,35,2.259665088,0.341628174,-1.549501136,0.000585866,0.000371785,"down","yes","Pcdhb11","protein_coding","chr18:29126669-29129062:+","gi|109506480|ref|XP_001055576.1|",3818,0,"PREDICTED: protocadherin-3 [Rattus norvegicus]","gi|564320525|ref|XM_001064927.4|",2394,0,"PREDICTED: Rattus norvegicus protocadherin beta 11 (Pcdhb11), mRNA","Q63418",1223,0,"Protocadherin-3",".",".",".",".","pfam08266","Cadherin_2","Cadherin-like. This cadherin domain is usually the most N-terminal copy of the domain.","GO:0007155|cell adhesion;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005887|integral component of plasma membrane;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;","K16494","PCDHB; protocadherin beta"]
["ENSRNOG00000021745",8,0.514643505,28,1.80773207,0.284690145,-1.812535541,0.000588539,0.000373398,"down","yes","Bhlhe22","protein_coding","chr2:100486400-100489510:+","gi|157822033|ref|NP_001102410.1|",1160,{"v":4e-146,"d":"4.00E-146"},"class E basic helix-loop-helix protein 22 [Rattus norvegicus]","gi|157822032|ref|NM_001108940.1|",3106,0,"Rattus norvegicus basic helix-loop-helix family, member e22 (Bhlhe22), mRNA","Q8C6A8",437,{"v":2e-142,"d":"2.00E-142"},"Class E basic helix-loop-helix protein 22",".",".",".",".","pfam00010","HLH","Helix-loop-helix DNA-binding domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0021540|corpus callosum morphogenesis;GO:0021796|cerebral cortex regionalization;GO:0021952|central nervous system projection neuron axonogenesis;GO:0021957|corticospinal tract morphogenesis;GO:0021960|anterior commissure morphogenesis;GO:0030182|neuron differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0060040|retinal bipolar neuron differentiation;GO:0060042|retina morphogenesis in camera-type eye;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003682|chromatin binding;GO:0042802|identical protein binding;GO:0046983|protein dimerization activity;GO:1990837|sequence-specific double-stranded DNA binding;","K09086","BHLHB4_5, BETA; class B basic helix-loop-helix protein 4/5"]
["ENSRNOG00000007354",27,1.736921831,58,3.74458786,0.463848599,-1.108274112,0.000632942,3.99837E-4,"down","yes","Trpa1","protein_coding","chr5:4379999-4433570:+","gi|46485385|ref|NP_997491.1|",6015,0,"transient receptor potential cation channel subfamily A member 1 [Rattus norvegicus]","gi|46485384|ref|NM_207608.1|",3369,0,"Rattus norvegicus transient receptor potential cation channel, subfamily A, member 1 (Trpa1), mRNA","Q6RI86",2321,0,"Transient receptor potential cation channel subfamily A member 1","all2748",123,{"v":2e-28,"d":"2.00E-28"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0006816|calcium ion transport;GO:0006874|cellular calcium ion homeostasis;GO:0007166|cell surface receptor signaling pathway;GO:0009409|response to cold;GO:0009410|response to xenobiotic stimulus;GO:0010033|response to organic substance;GO:0014070|response to organic cyclic compound;GO:0014832|urinary bladder smooth muscle contraction;GO:0019233|sensory perception of pain;GO:0034605|cellular response to heat;GO:0035774|positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0042542|response to hydrogen peroxide;GO:0048265|response to pain;GO:0050955|thermoception;GO:0050966|detection of mechanical stimulus involved in sensory perception of pain;GO:0050968|detection of chemical stimulus involved in sensory perception of pain;GO:0051209|release of sequestered calcium ion into cytosol;GO:0051289|protein homotetramerization;GO:0070417|cellular response to cold;GO:0070588|calcium ion transmembrane transport;GO:0071244|cellular response to carbon dioxide;GO:0071310|cellular response to organic substance;GO:0071313|cellular response to caffeine;GO:0097553|calcium ion transmembrane import into cytosol;GO:0098908|regulation of neuronal action potential;GO:1903522|regulation of blood circulation;GO:1903793|positive regulation of anion transport;GO:1904058|positive regulation of sensory perception of pain;","GO:0005887|integral component of plasma membrane;GO:0016324|apical plasma membrane;GO:0030424|axon;GO:0032421|stereocilium bundle;","GO:0005216|ion channel activity;GO:0005245|voltage-gated calcium channel activity;GO:0005262|calcium channel activity;GO:0005515|protein binding;GO:0015267|channel activity;GO:0015278|calcium-release channel activity;GO:0042802|identical protein binding;GO:0097604|temperature-gated cation channel activity;GO:1990760|osmolarity-sensing cation channel activity;","K04984","TRPA1, ANKTM1; transient receptor potential cation channel subfamily A member 1"]
["ENSRNOG00000029564",5,0.321652191,22,1.420360912,0.22645807,-2.142684143,0.000671193,0.000422878,"down","yes","Trat1","protein_coding","chr11:52035750-52077805:+","gi|83816943|ref|NP_001033070.1|",816,{"v":2e-102,"d":"2.00E-102"},"T cell receptor associated transmembrane adaptor 1 [Rattus norvegicus]","gi|83816942|ref|NM_001037981.1|",1820,0,"Rattus norvegicus T cell receptor associated transmembrane adaptor 1 (Trat1), mRNA","Q3UU67",282,{"v":1E-89,"d":"1.00E-89"},"T-cell receptor-associated transmembrane adapter 1",".",".",".",".","pfam15330","SIT","SHP2-interacting transmembrane adaptor protein, SIT. SIT, or SHP2-interacting transmembrane adaptor protein, is a disulfide-linked dimer that regulates human T Cell activation.","GO:0001920|negative regulation of receptor recycling;GO:0050850|positive regulation of calcium-mediated signaling;GO:0050862|positive regulation of T cell receptor signaling pathway;GO:0051051|negative regulation of transport;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0034451|centriolar satellite;GO:0042101|T cell receptor complex;GO:0072686|mitotic spindle;",".",".","."]
["ENSRNOG00000020118",10,0.643304382,31,2.001417649,0.321424357,-1.637448835,0.000758282,0.00047518,"down","yes","Nme5","protein_coding","chr18:26163555-26180794:-","gi|392334100|ref|XP_003753081.1|",1122,{"v":4e-149,"d":"4.00E-149"},"PREDICTED: nucleoside diphosphate kinase homolog 5 [Rattus norvegicus]","gi|672030575|ref|XM_003753033.3|",1177,0,"PREDICTED: Rattus norvegicus NME/NM23 family member 5 (Nme5), mRNA","Q99MH5",414,{"v":8e-142,"d":"8.00E-142"},"Nucleoside diphosphate kinase homolog 5","VC0756",103,{"v":7e-25,"d":"7.00E-25"},"COG0105","pfam00334","NDK","Nucleoside diphosphate kinase.","GO:0003351|epithelial cilium movement;GO:0006165|nucleoside diphosphate phosphorylation;GO:0006183|GTP biosynthetic process;GO:0006228|UTP biosynthetic process;GO:0006241|CTP biosynthetic process;GO:0007286|spermatid development;GO:0021591|ventricular system development;GO:0060271|cilium assembly;GO:1902176|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;","GO:0005576|extracellular region;GO:0005929|cilium;GO:0036126|sperm flagellum;","GO:0004550|nucleoside diphosphate kinase activity;","K20790","NME5; nucleoside diphosphate kinase homolog 5"]
["ENSRNOG00000019193",18,1.157947887,44,2.840721825,0.407624526,-1.294687237,0.000761741,0.000477137,"down","yes","Stx1b","protein_coding","chr1:182415546-182441280:-","gi|470636934|ref|XP_004323787.1|",1357,{"v":2E-175,"d":"2.00E-175"},"PREDICTED: syntaxin-1B [Tursiops truncatus]","gi|207138|gb|M95735.1|RATSYNB",2725,0,"Rattus norvegicus syntaxin B mRNA, complete cds","P61265",488,{"v":3e-163,"d":"3.00E-163"},"Syntaxin-1B","YMR183c",82,{"v":7e-16,"d":"7.00E-16"},"COG5074","pfam00804","Syntaxin","Syntaxin. Syntaxins are the prototype family of SNARE proteins. They usually consist of three main regions - a C-terminal transmembrane region, a central SNARE domain which is characteristic of and conserved in all syntaxins (pfam05739), and an N-terminal domain that is featured in this entry. This domain varies between syntaxin isoforms; in syntaxin 1A it is found as three alpha-helices with a left-handed twist. It may fold back on the SNARE domain to allow the molecule to adopt a 'closed' configuration that prevents formation of the core fusion complex - it thus has an auto-inhibitory role. The function of syntaxins is determined by their localisation. They are involved in neuronal exocytosis, ER-Golgi transport and Golgi-endosome transport, for example. They also interact with other proteins as well as those involved in SNARE complexes. These include vesicle coat proteins, Rab GTPases, and tethering factors.","GO:0001956|positive regulation of neurotransmitter secretion;GO:0006886|intracellular protein transport;GO:0006887|exocytosis;GO:0006904|vesicle docking involved in exocytosis;GO:0006906|vesicle fusion;GO:0010468|regulation of gene expression;GO:0010807|regulation of synaptic vesicle priming;GO:0010977|negative regulation of neuron projection development;GO:0015031|protein transport;GO:0016079|synaptic vesicle exocytosis;GO:0016081|synaptic vesicle docking;GO:0016192|vesicle-mediated transport;GO:0017157|regulation of exocytosis;GO:0031629|synaptic vesicle fusion to presynaptic active zone membrane;GO:0048278|vesicle docking;GO:0048791|calcium ion-regulated exocytosis of neurotransmitter;GO:0060025|regulation of synaptic activity;GO:0061669|spontaneous neurotransmitter secretion;GO:0072657|protein localization to membrane;GO:0098967|exocytic insertion of neurotransmitter receptor to postsynaptic membrane;GO:1903422|negative regulation of synaptic vesicle recycling;GO:1904050|positive regulation of spontaneous neurotransmitter secretion;GO:1905302|negative regulation of macropinocytosis;GO:2000463|positive regulation of excitatory postsynaptic potential;","GO:0005634|nucleus;GO:0005652|nuclear lamina;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0005886|plasma membrane;GO:0008021|synaptic vesicle;GO:0012505|endomembrane system;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0031201|SNARE complex;GO:0031594|neuromuscular junction;GO:0042734|presynaptic membrane;GO:0048787|presynaptic active zone membrane;GO:0098793|presynapse;","GO:0000149|SNARE binding;GO:0005102|signaling receptor binding;GO:0005484|SNAP receptor activity;GO:0005515|protein binding;GO:0019901|protein kinase binding;GO:0019904|protein domain specific binding;","K08486","STX1B_2_3; syntaxin 1B/2/3"]
["ENSRNOG00000066596",20,1.286608764,47,3.034407404,0.424006599,-1.237841376,0.000781196,0.00048868,"down","yes","ENSRNOG00000066596","lncRNA","chr16:18332870-18333956:+",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","pfam14800","DUF4481","Domain of unknown function (DUF4481).",".",".",".",".","."]
["ENSRNOG00000002361",0,0.032165219,11,0.710180456,0.045291614,-4.464612238,0.00080496,0.000502116,"down","yes","Prkg2","protein_coding","chr14:10559882-10666888:+","gi|6981402|ref|NP_037144.1|",4088,0,"cGMP-dependent protein kinase 2 [Rattus norvegicus]","gi|6981401|ref|NM_013012.1|",2940,0,"Rattus norvegicus protein kinase, cGMP-dependent, type II (Prkg2), mRNA","Q64595",1579,0,"cGMP-dependent protein kinase 2",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006468|protein phosphorylation;GO:0007623|circadian rhythm;GO:0032922|circadian regulation of gene expression;GO:0036289|peptidyl-serine autophosphorylation;GO:0045794|negative regulation of cell volume;GO:0071476|cellular hypotonic response;GO:0072659|protein localization to plasma membrane;GO:2001226|negative regulation of chloride transport;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016324|apical plasma membrane;GO:0031965|nuclear membrane;","GO:0004692|cGMP-dependent protein kinase activity;GO:0005524|ATP binding;GO:0030553|cGMP binding;GO:0042802|identical protein binding;","K19477","PRKG2; cGMP-dependent protein kinase 2 [EC:2.7.11.12]"]
["ENSRNOG00000006471",0,0.032165219,11,0.710180456,0.045291614,-4.464612238,0.00080496,0.000502116,"down","yes","ENSRNOG00000006471","protein_coding","chr7:109772593-109784561:-","gi|494573|pdb|1RTP|1",388,{"v":4e-42,"d":"4.00E-42"},"Chain 1, Refined X-ray Structure Of Rat Parvalbumin, A Mammalian Alpha-lineage Parvalbumin, At 2.0 A Resolution","gi|298892642|emb|FQ215367.1|",1173,0,"Rattus norvegicus TL0ACA48YI05 mRNA sequence","P02625",154,{"v":1e-43,"d":"1.00E-43"},"Parvalbumin alpha",".",".",".",".","pfam00036","EF-hand_1","EF hand. The EF-hands can be divided into two classes: signaling proteins and buffering/transport proteins. The first group is the largest and includes the most well-known members of the family such as calmodulin, troponin C and S100B. These proteins typically undergo a calcium-dependent conformational change which opens a target binding site. The latter group is represented by calbindin D9k and do not undergo calcium dependent conformational changes.","GO:0090102|cochlea development;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0030424|axon;GO:0032420|stereocilium;GO:0032437|cuticular plate;GO:0032991|protein-containing complex;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;","GO:0005509|calcium ion binding;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;","K23926","PVALB; parvalbumin alpha"]
["ENSRNOG00000021763",0,0.032165219,11,0.710180456,0.045291614,-4.464612238,0.00080496,0.000502116,"down","yes","Ffar4","protein_coding","chr1:235873576-235891597:+","gi|114052953|ref|NP_001040553.1|",1673,0,"free fatty acid receptor 4 [Rattus norvegicus]","gi|114052952|ref|NM_001047088.1|",1379,0,"Rattus norvegicus free fatty acid receptor 4 (Ffar4), mRNA","Q2AC31",649,0,"Free fatty acid receptor 4",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001818|negative regulation of cytokine production;GO:0006954|inflammatory response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0010827|regulation of glucose transmembrane transport;GO:0032691|negative regulation of interleukin-1 beta production;GO:0036321|ghrelin secretion;GO:0043066|negative regulation of apoptotic process;GO:0043950|positive regulation of cAMP-mediated signaling;GO:0045444|fat cell differentiation;GO:0045669|positive regulation of osteoblast differentiation;GO:0046879|hormone secretion;GO:0050728|negative regulation of inflammatory response;GO:0050872|white fat cell differentiation;GO:0050873|brown fat cell differentiation;GO:0050912|detection of chemical stimulus involved in sensory perception of taste;GO:0070094|positive regulation of glucagon secretion;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0090275|negative regulation of somatostatin secretion;GO:0090336|positive regulation of brown fat cell differentiation;GO:0120162|positive regulation of cold-induced thermogenesis;","GO:0005765|lysosomal membrane;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005929|cilium;GO:0010008|endosome membrane;GO:0030139|endocytic vesicle;GO:0060170|ciliary membrane;","GO:0004930|G protein-coupled receptor activity;GO:0005504|fatty acid binding;GO:0008527|taste receptor activity;GO:1990763|arrestin family protein binding;","K08425","FFAR4, GPR120; free fatty acid receptor 4"]
["ENSRNOG00000023116",0,0.032165219,11,0.710180456,0.045291614,-4.464612238,0.00080496,0.000502116,"down","yes","Agmo","protein_coding","chr6:53986292-54317623:+","gi|209571479|ref|NP_001129371.1|",2206,0,"alkylglycerol monooxygenase [Rattus norvegicus]","gi|298882661|emb|FQ211046.1|",1445,0,"Rattus norvegicus TL0ABA18YF24 mRNA sequence","A0JPQ8",854,0,"Alkylglycerol monooxygenase","CC1444",182,{"v":2E-50,"d":"2.00E-50"},"COG3000","pfam04116","FA_hydroxylase","Fatty acid hydroxylase superfamily. This superfamily includes fatty acid and carotene hydroxylases and sterol desaturases. Beta-carotene hydroxylase is involved in zeaxanthin synthesis by hydroxylating beta-carotene, but the enzyme may be involved in other pathways. This family includes C-5 sterol desaturase and C-4 sterol methyl oxidase. Members of this family are involved in cholesterol biosynthesis and biosynthesis a plant cuticular wax. These enzymes contain two copies of a HXHH motif. Members of this family are integral membrane proteins.","GO:0006643|membrane lipid metabolic process;GO:0008610|lipid biosynthetic process;GO:0046485|ether lipid metabolic process;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0005506|iron ion binding;GO:0050479|glyceryl-ether monooxygenase activity;","K15537","AGMO; alkylglycerol monooxygenase [EC:1.14.16.5]"]
["ENSRNOG00000046655",0,0.032165219,11,0.710180456,0.045291614,-4.464612238,0.00080496,0.000502116,"down","yes","AABR07051395.1","protein_coding","chr3:13021696-13028559:-","gi|564301320|ref|XP_006224400.1|",673,{"v":8e-85,"d":"8.00E-85"},"PREDICTED: proline-rich protein HaeIII subfamily 1-like [Rattus norvegicus]","gi|672016558|ref|XM_006224338.2|",747,0,"PREDICTED: Rattus norvegicus proline-rich protein HaeIII subfamily 1-like (LOC102546892), mRNA","A0A1B0GWB2",156,{"v":2e-44,"d":"2.00E-44"},"Proline rich transmembrane protein 1B",".",".",".",".","pfam04505","Dispanin","Interferon-induced transmembrane protein. This family includes the human leukocyte antigen CD225, which is an interferon inducible transmembrane protein, and is associated with interferon induced cell growth suppression.",".",".",".",".","."]
["ENSRNOG00000063175",0,0.032165219,11,0.710180456,0.045291614,-4.464612238,0.00080496,0.000502116,"down","yes","Catsperb","protein_coding","chr6:120418609-120707182:-","gi|672021098|ref|XP_008774534.1|",5104,0,"PREDICTED: cation channel sperm-associated protein subunit beta isoform X1 [Rattus norvegicus]","gi|672021097|ref|XM_008776312.1|",2012,0,"PREDICTED: Rattus norvegicus cation channel sperm-associated protein subunit beta-like (LOC100910102), transcript variant X1, mRNA","A2RTF1",1709,0,"Cation channel sperm-associated protein subunit beta",".",".",".",".","pfam15149","CATSPERB","Cation channel sperm-associated protein subunit beta protein family. The function of this family of transmembrane proteins, CATSPERB, has not, as yet, been determined. However, it is thought to play a role in sperm hyperactivation by associating with CATSPER1. This family of proteins is found in eukaryotes. Proteins in this family are typically between 220 and 1107 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000071204",0,0.032165219,11,0.710180456,0.045291614,-4.464612238,0.00080496,0.000502116,"down","yes","Olr1423","protein_coding","chr10:42880571-42886921:-","gi|47576057|ref|NP_001000006.1|",1385,{"v":1E-175,"d":"1.00E-175"},"olfactory receptor Olr1423 [Rattus norvegicus]","gi|110292907|gb|AC141398.4|",1955,0,"Rattus norvegicus BAC CH230-12M22 () complete sequence","Q8NH02",391,{"v":2e-122,"d":"2.00E-122"},"Olfactory receptor 2T29",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.",".",".",".",".","."]
["ENSRNOG00000012134",2,0.128660876,15,0.968427895,0.132855401,-2.912071215,0.0008367,5.20664E-4,"down","yes","Scn4a","protein_coding","chr10:91246936-91296545:-","gi|564374804|ref|XP_006247621.1|",8783,0,"PREDICTED: sodium channel protein type 4 subunit alpha isoform X1 [Rattus norvegicus]","gi|6981511|ref|NM_013178.1|",6922,0,"Rattus norvegicus sodium voltage-gated channel alpha subunit 4 (Scn4a), mRNA","P15390",3374,0,"Sodium channel protein type 4 subunit alpha",".",".",".",".","pfam06512","Na_trans_assoc","Sodium ion transport-associated. Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.","GO:0006812|cation transport;GO:0006813|potassium ion transport;GO:0006814|sodium ion transport;GO:0015871|choline transport;GO:0019228|neuronal action potential;GO:0034765|regulation of ion transmembrane transport;GO:0035725|sodium ion transmembrane transport;GO:0086010|membrane depolarization during action potential;GO:0100001|regulation of skeletal muscle contraction by action potential;","GO:0001518|voltage-gated sodium channel complex;GO:0005887|integral component of plasma membrane;GO:0030424|axon;","GO:0005244|voltage-gated ion channel activity;GO:0005248|voltage-gated sodium channel activity;","K04837","SCN4A, NAV1.4; voltage-gated sodium channel type IV alpha"]
["ENSRNOG00000043203",2,0.128660876,15,0.968427895,0.132855401,-2.912071215,0.0008367,5.20664E-4,"down","yes","Krt75","protein_coding","chr7:132688237-132697345:-","gi|148672089|gb|EDL04036.1|",2007,0,"keratin 75, partial [Mus musculus]","gi|672059945|ref|XM_006242325.2|",2159,0,"PREDICTED: Rattus norvegicus keratin 75 (Krt75), transcript variant X1, mRNA","Q6IG05",766,0,"Keratin, type II cytoskeletal 75",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0002244|hematopoietic progenitor cell differentiation;","GO:0005882|intermediate filament;GO:0045095|keratin filament;",".","K07605","KRT2; type II keratin, basic"]
["ENSRNOG00000048139",2,0.128660876,15,0.968427895,0.132855401,-2.912071215,0.0008367,5.20664E-4,"down","yes","Ncmap","protein_coding","chr5:147610677-147618775:-","gi|148698037|gb|EDL29984.1|",349,{"v":5e-39,"d":"5.00E-39"},"RIKEN cDNA A330049M08, isoform CRA_d, partial [Mus musculus]","gi|359807098|ref|NM_001253918.1|",510,0,"Rattus norvegicus noncompact myelin associated protein (Ncmap), mRNA","F1M2Z5",130,{"v":1e-37,"d":"1.00E-37"},"Noncompact myelin-associated protein",".",".",".",".","pfam09436","DUF2016","Domain of unknown function (DUF2016). A predicted alpha+beta domain that is usually fused N-terminal to the JAB metallopeptidase. This protein in turn is found in conserved gene neighborhoods that include genes encoding the bacterial homologs of the ubiquitin modification system such as the E1, E2 and Ub proteins. The domain is also known as the JAB-N domain.","GO:0031641|regulation of myelination;GO:0031643|positive regulation of myelination;GO:0032290|peripheral nervous system myelin formation;","GO:0005887|integral component of plasma membrane;GO:0033270|paranode region of axon;GO:0043220|Schmidt-Lanterman incisure;","GO:0019911|structural constituent of myelin sheath;",".","."]
["ENSRNOG00000062707",2,0.128660876,15,0.968427895,0.132855401,-2.912071215,0.0008367,5.20664E-4,"down","yes","ENSRNOG00000062707","lncRNA","chr2:51977201-51983724:-",".",".",".",".","gi|672041660|ref|XR_590924.1|",538,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102556643 (LOC102556643), transcript variant X4, ncRNA",".",".",".",".",".",".",".",".","pfam07793","DUF1631","Protein of unknown function (DUF1631). The members of this family are sequences derived from a group of hypothetical proteins expressed by certain bacterial species. The region concerned is approximately 440 amino acid residues in length.",".",".",".",".","."]
["ENSRNOG00000070630",12,0.771965258,34,2.195103228,0.351676062,-1.50768096,8.96545E-4,5.56147E-4,"down","yes","ENSRNOG00000070630","lncRNA","chr20:7144999-7149171:-",".",".",".",".","gi|672031552|ref|XR_343719.2|",645,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102557535 (LOC102557535), ncRNA",".",".",".",".",".",".",".",".","pfam15498","Dendrin","Nephrin and CD2AP-binding protein, Dendrin. Dendrin is a family of eukaryotic proteins found in the podocytes of the kidneys. Dendrin, originally identified in telencephalic dendrites, is a constituent of the slit diaphragm, SD, complex of podocytes, where it directly binds to nephrin and CD2AP. Kidney podocytes and their slit diaphragms (SDs) form the final barrier to urinary protein loss. SD proteins also participate in intracellular signalling pathways. Dendrin appears to prevent programmed cell death (apoptosis) through its binding to nephrin. The SD protein nephrin serves as a component of a signalling complex that directly links podocyte junctional integrity to actin cytoskeletal dynamics. Thus, dendrin is identified as an SD family with proapoptotic signalling properties that accumulates in the podocyte nucleus in response to glomerular injury.",".",".",".",".","."]
["ENSRNOG00000026861",25,1.608260955,54,3.486340421,0.461303476,-1.116211932,0.000912487,0.000565695,"down","yes","Zscan18","protein_coding","chr1:73332889-73345897:-","gi|564296650|ref|XP_006223058.1|",2493,0,"PREDICTED: zinc finger and SCAN domain-containing protein 18 isoform X1 [Rattus norvegicus]","gi|672034781|ref|XM_006228133.2|",3863,0,"PREDICTED: Rattus norvegicus zinc finger and SCAN domain containing 18 (Zscan18), transcript variant X8, mRNA","Q8TBC5",357,{"v":5E-108,"d":"5.00E-108"},"Zinc finger and SCAN domain-containing protein 18",".",".",".",".","pfam02023","SCAN","SCAN domain. The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerization.",".","GO:0005634|nucleus;",".","K09230","SCAN; SCAN domain-containing zinc finger protein"]
["ENSRNOG00000065957",23,1.479600078,51,3.292654842,0.449363857,-1.154044005,0.000932194,0.00057732,"down","yes","ENSRNOG00000065957","lncRNA","chr1:258564709-258606618:-","gi|149040521|gb|EDL94559.1|",215,{"v":8e-17,"d":"8.00E-17"},"rCG57731 [Rattus norvegicus]","gi|24476171|gb|AC098733.2|",1351,0,"Mus musculus BAC clone RP23-103C10 from 19, complete sequence",".",".",".",".",".",".",".",".","pfam10063","DUF2301","Uncharacterized integral membrane protein (DUF2301). This domain, found in various hypothetical bacterial proteins, has no known function.",".",".",".",".","."]
["ENSRNOG00000064030",8,0.514643505,27,1.743170211,0.295234225,-1.760068122,0.000942503,0.000583262,"down","yes","ENSRNOG00000064030","lncRNA","chr18:59826321-59834159:-","gi|149064506|gb|EDM14709.1|",141,2e-09,"rCG46976, isoform CRA_d [Rattus norvegicus]",".",".",".",".",".",".",".",".",".",".",".",".","pfam02135","zf-TAZ","TAZ zinc finger. The TAZ2 domain of CBP binds to other transcription factors such as the p53 tumor suppressor protein, E1A oncoprotein, MyoD, and GATA-1. The zinc coordinating motif that is necessary for binding to target DNA sequences consists of HCCC.",".",".",".",".","."]
["ENSRNOG00000011518",14,0.900626135,37,2.388788807,0.377022084,-1.407279063,0.000999774,0.000617366,"down","yes","Dusp26","protein_coding","chr16:61041792-61049051:-","gi|640815631|ref|XP_008064591.1|",973,{"v":8e-126,"d":"8.00E-126"},"PREDICTED: dual specificity protein phosphatase 26 [Tarsius syrichta]","gi|59891426|ref|NM_001012352.1|",1599,0,"Rattus norvegicus dual specificity phosphatase 26 (putative) (Dusp26), mRNA","Q5FVI9",368,{"v":1e-123,"d":"1.00E-123"},"Dual specificity protein phosphatase 26","SPBC17A3.06",63.2,{"v":5e-10,"d":"5.00E-10"},"COG2453","pfam00782","DSPc","Dual specificity phosphatase, catalytic domain. Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a \"recognition\" region.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006470|protein dephosphorylation;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0043409|negative regulation of MAPK cascade;GO:0044387|negative regulation of protein kinase activity by regulation of protein phosphorylation;GO:0045785|positive regulation of cell adhesion;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:1902310|positive regulation of peptidyl-serine dephosphorylation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;","GO:0002039|p53 binding;GO:0004721|phosphoprotein phosphatase activity;GO:0004725|protein tyrosine phosphatase activity;GO:0008138|protein tyrosine/serine/threonine phosphatase activity;GO:0033549|MAP kinase phosphatase activity;GO:0036424|L-phosphoserine phosphatase activity;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;","K14165","K14165; atypical dual specificity phosphatase [EC:3.1.3.16 3.1.3.48]"]
["ENSRNOG00000017136",3,0.192991315,17,1.097551614,0.175838031,-2.50768096,0.001021457,0.000629666,"down","yes","Syt17","protein_coding","chr1:172696120-172761960:-","gi|20301992|ref|NP_620204.1|",2160,0,"synaptotagmin-17 [Rattus norvegicus]","gi|755521954|ref|XM_006507204.2|",1749,0,"PREDICTED: Mus musculus synaptotagmin XVII (Syt17), transcript variant X3, mRNA","Q62807",836,0,"Synaptotagmin-17",".",".",".",".","pfam00168","C2","C2 domain.","GO:0006887|exocytosis;GO:0014059|regulation of dopamine secretion;GO:0016192|vesicle-mediated transport;GO:0017156|calcium ion regulated exocytosis;GO:0017158|regulation of calcium ion-dependent exocytosis;GO:0030154|cell differentiation;GO:0071277|cellular response to calcium ion;GO:1903861|positive regulation of dendrite extension;","GO:0005802|trans-Golgi network;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0070382|exocytic vesicle;","GO:0000149|SNARE binding;GO:0001786|phosphatidylserine binding;GO:0005509|calcium ion binding;GO:0005544|calcium-dependent phospholipid binding;GO:0019905|syntaxin binding;GO:0030276|clathrin binding;","K19915","SYT17; synaptotagmin-17"]
["ENSRNOG00000017686",3,0.192991315,17,1.097551614,0.175838031,-2.50768096,0.001021457,0.000629666,"down","yes","Pi15","protein_coding","chr5:1395094-1423213:-","gi|157817111|ref|NP_001100387.1|",1387,0,"peptidase inhibitor 15 precursor [Rattus norvegicus]","gi|157817110|ref|NM_001106917.1|",1359,0,"Rattus norvegicus peptidase inhibitor 15 (Pi15), mRNA","O43692",502,{"v":8e-177,"d":"8.00E-177"},"Peptidase inhibitor 15","YJL079c",57.8,2E-8,"COG2340","pfam00188","CAP","Cysteine-rich secretory protein family. This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organisms, including prokaryotes and non-vertebrate eukaryotes, The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumor suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilisation. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The Ca++-chelating function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how helothermine from Heloderma horridum horridum blocks the Ca++ transporting ryanodine receptors.","GO:0006508|proteolysis;","GO:0005615|extracellular space;","GO:0008233|peptidase activity;","K24836","PI15, CRISP8; peptidase inhibitor 15"]
["ENSRNOG00000060087",3,0.192991315,17,1.097551614,0.175838031,-2.50768096,0.001021457,0.000629666,"down","yes","Adra1b","protein_coding","chr10:28255025-28312919:-","gi|543734|sp|P15823.2|ADA1B_RAT",2601,0,"RecName: Full=Alpha-1B adrenergic receptor; AltName: Full=Alpha-1B adrenoreceptor; Short=Alpha-1B adrenoceptor","gi|47575852|ref|NM_016991.2|",2484,0,"Rattus norvegicus adrenoceptor alpha 1B (Adra1b), mRNA","P15823",1006,0,"Alpha-1B adrenergic receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001974|blood vessel remodeling;GO:0001975|response to amphetamine;GO:0001987|vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure;GO:0001996|positive regulation of heart rate by epinephrine-norepinephrine;GO:0001997|positive regulation of the force of heart contraction by epinephrine-norepinephrine;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007267|cell-cell signaling;GO:0007512|adult heart development;GO:0007626|locomotory behavior;GO:0008217|regulation of blood pressure;GO:0008542|visual learning;GO:0009410|response to xenobiotic stimulus;GO:0009725|response to hormone;GO:0010259|multicellular organism aging;GO:0019229|regulation of vasoconstriction;GO:0035024|negative regulation of Rho protein signal transduction;GO:0035265|organ growth;GO:0042593|glucose homeostasis;GO:0043278|response to morphine;GO:0043410|positive regulation of MAPK cascade;GO:0043627|response to estrogen;GO:0045818|negative regulation of glycogen catabolic process;GO:0045819|positive regulation of glycogen catabolic process;GO:0045907|positive regulation of vasoconstriction;GO:0048148|behavioral response to cocaine;GO:0048545|response to steroid hormone;GO:0055117|regulation of cardiac muscle contraction;GO:0061049|cell growth involved in cardiac muscle cell development;GO:0071875|adrenergic receptor signaling pathway;GO:0071880|adenylate cyclase-activating adrenergic receptor signaling pathway;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005901|caveola;GO:0014704|intercalated disc;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030315|T-tubule;GO:0031965|nuclear membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004937|alpha1-adrenergic receptor activity;GO:0046982|protein heterodimerization activity;","K04136","ADRA1B; adrenergic receptor alpha-1B"]
["ENSRNOG00000063449",3,0.192991315,17,1.097551614,0.175838031,-2.50768096,0.001021457,0.000629666,"down","yes","ENSRNOG00000063449","lncRNA","chr7:110021779-110033215:+","gi|149062508|gb|EDM12931.1|",205,{"v":3e-27,"d":"3.00E-27"},"ciliary neurotrophic factor, isoform CRA_d [Rattus norvegicus]","gi|672060355|ref|XR_593644.1|",1737,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102547102 (LOC102547102), transcript variant X5, ncRNA",".",".",".",".",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.",".",".",".",".","."]
["ENSRNOG00000013887",11,0.70763482,32,2.065979509,0.342517831,-1.545749001,0.001032197,0.000635669,"down","yes","Adra2b","protein_coding","chr3:114585169-114589355:+","gi|304434812|ref|NP_612514.2|",2120,0,"alpha-2B adrenergic receptor [Rattus norvegicus]","gi|304434811|ref|NM_138505.2|",4047,0,"Rattus norvegicus adrenoceptor alpha 2B (Adra2b), mRNA","P19328",798,0,"Alpha-2B adrenergic receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0000165|MAPK cascade;GO:0001525|angiogenesis;GO:0003056|regulation of vascular smooth muscle contraction;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007565|female pregnancy;GO:0030168|platelet activation;GO:0032148|activation of protein kinase B activity;GO:0035624|receptor transactivation;GO:0043410|positive regulation of MAPK cascade;GO:0045666|positive regulation of neuron differentiation;GO:0045777|positive regulation of blood pressure;GO:0070474|positive regulation of uterine smooth muscle contraction;GO:0071875|adrenergic receptor signaling pathway;GO:0071880|adenylate cyclase-activating adrenergic receptor signaling pathway;","GO:0005829|cytosol;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0004930|G protein-coupled receptor activity;GO:0004935|adrenergic receptor activity;GO:0004938|alpha2-adrenergic receptor activity;GO:0005515|protein binding;GO:0051379|epinephrine binding;","K04139","ADRA2B; adrenergic receptor alpha-2B"]
["ENSRNOG00000021037",1,0.064330438,12,0.774742316,0.083034626,-3.59014312,0.001056433,0.000649234,"down","yes","Spaca4","protein_coding","chr1:96195315-96196237:-","gi|532048106|ref|XP_005366831.1|",487,{"v":9e-57,"d":"9.00E-57"},"PREDICTED: sperm acrosome membrane-associated protein 4 [Microtus ochrogaster]","gi|88023877|gb|AC136191.5|",923,0,"Rattus norvegicus BAC CH230-52I17 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q80ZQ0",162,{"v":1e-47,"d":"1.00E-47"},"Sperm acrosome membrane-associated protein 4",".",".",".",".","pfam00021","UPAR_LY6","u-PAR/Ly-6 domain. This extracellular disulphide bond rich domain is related to pfam00087.",".",".",".","K19894","SPACA4, SAMP14; sperm acrosome membrane-associated protein 4"]
["ENSRNOG00000057264",1,0.064330438,12,0.774742316,0.083034626,-3.59014312,0.001056433,0.000649234,"down","yes","Tex49","protein_coding","chr7:129720950-129742485:+","gi|197386924|ref|NP_001128000.1|",703,{"v":3e-92,"d":"3.00E-92"},"uncharacterized protein LOC300207 [Rattus norvegicus]","gi|197386923|ref|NM_001134528.1|",526,0,"Rattus norvegicus hypothetical LOC300207 (RGD1305928), mRNA",".",".",".",".",".",".",".",".","pfam03772","Competence","Competence protein. Members of this family are integral membrane proteins with 6 predicted transmembrane helices. Some members of this family have been shown to be essential for bacterial competence in uptake of extracellular DNA. These proteins may transport DNA across the cell membrane. These proteins contain a highly conserved motif in the amino terminal transmembrane region that has two histidines that may form a metal binding site.",".",".",".",".","."]
["ENSRNOG00000004255",6,0.385982629,23,1.484922772,0.25993448,-1.943780075,0.001093343,0.000669858,"down","yes","Tstd1","protein_coding","chr13:83822035-83854885:+","gi|157818617|ref|NP_001102547.1|",2795,0,"rho GTPase-activating protein 30 [Rattus norvegicus]","gi|298891039|emb|FQ211641.1|",2658,0,"Rattus norvegicus TL0AAA84YN09 mRNA sequence","Q640N3",854,0,"Rho GTPase-activating protein 30",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0000432|positive regulation of transcription from RNA polymerase II promoter by glucose;GO:0001666|response to hypoxia;GO:0006006|glucose metabolic process;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0009411|response to UV;GO:0019086|late viral transcription;GO:0032869|cellular response to insulin stimulus;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0055088|lipid homeostasis;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003690|double-stranded DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0019899|enzyme binding;GO:0019901|protein kinase binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0042826|histone deacetylase binding;GO:0043425|bHLH transcription factor binding;GO:0043565|sequence-specific DNA binding;GO:0044877|protein-containing complex binding;GO:0046982|protein heterodimerization activity;GO:1990837|sequence-specific double-stranded DNA binding;","K09106","USF; upstream stimulatory factor"]
["ENSRNOG00000049880",31,1.994243584,62,4.002835299,0.498207754,-1.005180619,0.001106001,0.000677178,"down","yes","Tmem200c","protein_coding","chr9:108805787-108812226:+","gi|353703760|ref|NP_001238855.1|",1822,0,"transmembrane protein 200C [Rattus norvegicus]","gi|353703759|ref|NM_001251926.1|",3064,0,"Rattus norvegicus transmembrane protein 200C (Tmem200c), mRNA","A6NKL6",390,{"v":3e-119,"d":"3.00E-119"},"Transmembrane protein 200C",".",".",".",".","pfam10177","DUF2371","Uncharacterized conserved protein (DUF2371). This is a family of proteins conserved from nematodes to humans. The function is not known.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000029244",18,1.157947887,43,2.776159965,0.417104166,-1.261520373,1.109028E-3,0.000678885,"down","yes","ENSRNOG00000029244","protein_coding","chr18:29117701-29122146:+","gi|167736398|ref|NP_001108075.1|",3826,0,"protocadherin beta-5 precursor [Rattus norvegicus]","gi|86440007|gb|AC096374.7|",2588,0,"Rattus norvegicus BAC CH230-17K7 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q91XZ4",1233,0,"Protocadherin beta-6",".",".",".",".","pfam08266","Cadherin_2","Cadherin-like. This cadherin domain is usually the most N-terminal copy of the domain.","GO:0007155|cell adhesion;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005887|integral component of plasma membrane;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;","K16494","PCDHB; protocadherin beta"]
["ENSRNOG00000019336",22,1.41526964,49,3.163531123,0.447370228,-1.160458845,0.001117721,0.000683914,"down","yes","Gata3","protein_coding","chr17:68643873-68665391:+","gi|18959228|ref|NP_579827.1|",1771,0,"trans-acting T-cell-specific transcription factor GATA-3 [Rattus norvegicus]","gi|672082505|ref|XM_006254253.2|",2791,0,"PREDICTED: Rattus norvegicus GATA binding protein 3 (Gata3), transcript variant X1, mRNA","P23772",677,0,"Trans-acting T-cell-specific transcription factor GATA-3","SPCC1393.08",107,{"v":5e-23,"d":"5.00E-23"},"COG5641","pfam00320","GATA","GATA zinc finger. This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contains a single copy of the domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0000902|cell morphogenesis;GO:0001701|in utero embryonic development;GO:0001709|cell fate determination;GO:0001764|neuron migration;GO:0001775|cell activation;GO:0001806|type IV hypersensitivity;GO:0001817|regulation of cytokine production;GO:0001819|positive regulation of cytokine production;GO:0001822|kidney development;GO:0001823|mesonephros development;GO:0002088|lens development in camera-type eye;GO:0002520|immune system development;GO:0002572|pro-T cell differentiation;GO:0003180|aortic valve morphogenesis;GO:0003215|cardiac right ventricle morphogenesis;GO:0003281|ventricular septum development;GO:0006338|chromatin remodeling;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006959|humoral immune response;GO:0007165|signal transduction;GO:0007399|nervous system development;GO:0007411|axon guidance;GO:0008285|negative regulation of cell proliferation;GO:0008584|male gonad development;GO:0009410|response to xenobiotic stimulus;GO:0009615|response to virus;GO:0009791|post-embryonic development;GO:0009967|positive regulation of signal transduction;GO:0010332|response to gamma radiation;GO:0010595|positive regulation of endothelial cell migration;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010719|negative regulation of epithelial to mesenchymal transition;GO:0010975|regulation of neuron projection development;GO:0014065|phosphatidylinositol 3-kinase signaling;GO:0030182|neuron differentiation;GO:0030217|T cell differentiation;GO:0030218|erythrocyte differentiation;GO:0030856|regulation of epithelial cell differentiation;GO:0031929|TOR signaling;GO:0032689|negative regulation of interferon-gamma production;GO:0032703|negative regulation of interleukin-2 production;GO:0032736|positive regulation of interleukin-13 production;GO:0032753|positive regulation of interleukin-4 production;GO:0032754|positive regulation of interleukin-5 production;GO:0033077|T cell differentiation in thymus;GO:0033600|negative regulation of mammary gland epithelial cell proliferation;GO:0035162|embryonic hemopoiesis;GO:0035457|cellular response to interferon-alpha;GO:0035799|ureter maturation;GO:0035898|parathyroid hormone secretion;GO:0042421|norepinephrine biosynthetic process;GO:0042472|inner ear morphogenesis;GO:0043370|regulation of CD4-positive, alpha-beta T cell differentiation;GO:0043523|regulation of neuron apoptotic process;GO:0043583|ear development;GO:0043627|response to estrogen;GO:0045061|thymic T cell selection;GO:0045064|T-helper 2 cell differentiation;GO:0045165|cell fate commitment;GO:0045471|response to ethanol;GO:0045582|positive regulation of T cell differentiation;GO:0045597|positive regulation of cell differentiation;GO:0045599|negative regulation of fat cell differentiation;GO:0045786|negative regulation of cell cycle;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048469|cell maturation;GO:0048485|sympathetic nervous system development;GO:0048538|thymus development;GO:0048568|embryonic organ development;GO:0048589|developmental growth;GO:0048646|anatomical structure formation involved in morphogenesis;GO:0048872|homeostasis of number of cells;GO:0050728|negative regulation of inflammatory response;GO:0050852|T cell receptor signaling pathway;GO:0051569|regulation of histone H3-K4 methylation;GO:0051897|positive regulation of protein kinase B signaling;GO:0060017|parathyroid gland development;GO:0060037|pharyngeal system development;GO:0060065|uterus development;GO:0060231|mesenchymal to epithelial transition;GO:0060374|mast cell differentiation;GO:0060676|ureteric bud formation;GO:0061085|regulation of histone H3-K27 methylation;GO:0061290|canonical Wnt signaling pathway involved in metanephric kidney development;GO:0071345|cellular response to cytokine stimulus;GO:0071353|cellular response to interleukin-4;GO:0071356|cellular response to tumor necrosis factor;GO:0071442|positive regulation of histone H3-K14 acetylation;GO:0071599|otic vesicle development;GO:0071773|cellular response to BMP stimulus;GO:0072107|positive regulation of ureteric bud formation;GO:0072178|nephric duct morphogenesis;GO:0072179|nephric duct formation;GO:0072182|regulation of nephron tubule epithelial cell differentiation;GO:0072197|ureter morphogenesis;GO:0072676|lymphocyte migration;GO:0090102|cochlea development;GO:1901536|negative regulation of DNA demethylation;GO:1902895|positive regulation of pri-miRNA transcription by RNA polymerase II;GO:2000114|regulation of establishment of cell polarity;GO:2000146|negative regulation of cell motility;GO:2000352|negative regulation of endothelial cell apoptotic process;GO:2000553|positive regulation of T-helper 2 cell cytokine production;GO:2000607|negative regulation of cell proliferation involved in mesonephros development;GO:2000611|positive regulation of thyroid hormone generation;GO:2000617|positive regulation of histone H3-K9 acetylation;GO:2000679|positive regulation of transcription regulatory region DNA binding;GO:2000683|regulation of cellular response to X-ray;GO:2000703|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation;GO:2000734|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987|proximal promoter sequence-specific DNA binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0005134|interleukin-2 receptor binding;GO:0008270|zinc ion binding;GO:0042802|identical protein binding;GO:0043565|sequence-specific DNA binding;GO:0070888|E-box binding;GO:0071837|HMG box domain binding;GO:1990837|sequence-specific double-stranded DNA binding;","K17895","GATA3; GATA-binding protein 3"]
["ENSRNOG00000035513",5,0.321652191,21,1.355799053,0.237241788,-2.075569947,1.128111E-3,0.000689902,"down","yes","Mir214","miRNA","chr13:74588372-74588481:+",".",".",".",".","gi|987976947|emb|LT160000.1|",110,{"v":2e-49,"d":"2.00E-49"},"Macaca fascicularis complete genome, chromosome chr1",".",".",".",".",".",".",".",".","pfam00303","Thymidylat_synt","Thymidylate synthase.","GO:0045591|positive regulation of regulatory T cell differentiation;",".",".",".","."]
["ENSRNOG00000007014",25,1.608260955,53,3.421778562,0.470007315,-1.089244884,0.001277438,0.000777063,"down","yes","ENSRNOG00000007014","protein_coding","chrX:36907850-37150555:+","gi|164565391|ref|NP_001106837.1|",4764,0,"connector enhancer of kinase suppressor of ras 2 isoform 1 [Rattus norvegicus]","gi|894216332|ref|NM_177751.3|",4616,0,"Mus musculus connector enhancer of kinase suppressor of Ras 2 (Cnksr2), transcript variant 1, mRNA","Q9Z1T4",1839,0,"Connector enhancer of kinase suppressor of ras 2",".",".",".",".","pfam06663","DUF1170","Protein of unknown function (DUF1170). This family represents a conserved region of unknown function within MAGUIN, a neuronal membrane-associated guanylate kinase-interacting protein. This region is situated between the pfam00595 and pfam00169 domains. All family members also contain an N-terminal pfam00536 domain.","GO:0009966|regulation of signal transduction;GO:0035556|intracellular signal transduction;GO:0099173|postsynapse organization;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0045211|postsynaptic membrane;GO:0098978|glutamatergic synapse;GO:0099147|extrinsic component of postsynaptic density membrane;","GO:0005515|protein binding;GO:0019901|protein kinase binding;GO:0042802|identical protein binding;","K17536","CNKSR2, CNK2, KSR2; connector enhancer of kinase suppressor of Ras 2"]
["ENSRNOG00000068149",25,1.608260955,53,3.421778562,0.470007315,-1.089244884,0.001277438,0.000777063,"down","yes","ENSRNOG00000068149","lncRNA","chr18:31235874-31237913:+",".",".",".",".","gi|672083164|ref|XM_006254663.2|",2040,0,"PREDICTED: Rattus norvegicus Rho GTPase activating protein 26 (Arhgap26), transcript variant X4, mRNA",".",".",".",".",".",".",".",".","pfam05024","Gpi1","N-acetylglucosaminyl transferase component (Gpi1). Glycosylphosphatidylinositol (GPI) represents an important anchoring molecule for cell surface proteins.The first step in its synthesis is the transfer of N-acetylglucosamine (GlcNAc) from UDP-N-acetylglucosamine to phosphatidylinositol (PI). This chemically simple step is genetically complex because three or four genes are required in both yeast (GPI1, GPI2 and GPI3) and mammals (GPI1, PIG A, PIG H and PIG C), respectively.",".",".",".",".","."]
["ENSRNOG00000020344",19,1.222278326,44,2.840721825,0.430270333,-1.216684725,1.343272E-3,8.1598E-4,"down","yes","Sntb2","protein_coding","chr19:34831584-34914113:+","gi|274315796|ref|NP_001162145.1|",2167,0,"beta-2-syntrophin [Rattus norvegicus]","gi|274315795|ref|NM_001168674.1|",1698,0,"Rattus norvegicus syntrophin, beta 2 (Sntb2), mRNA","Q61235",827,0,"Beta-2-syntrophin",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.",".","GO:0005622|intracellular;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0016010|dystrophin-associated glycoprotein complex;GO:0032991|protein-containing complex;GO:0045202|synapse;","GO:0005198|structural molecule activity;","K24064","SNTB; beta-syntrophin"]
["ENSRNOG00000048161",8,0.514643505,26,1.678608351,0.306589387,-1.705620337,1.499668E-3,0.000906275,"down","yes","Tlr9","protein_coding","chr8:106864680-106868796:+","gi|149018685|gb|EDL77326.1|",5007,0,"toll-like receptor 9 [Rattus norvegicus]","gi|37693511|ref|NM_198131.1|",3267,0,"Rattus norvegicus toll-like receptor 9 (Tlr9), mRNA","Q9EQU3",1627,0,"Toll-like receptor 9","alr0124_1",68.6,{"v":5e-11,"d":"5.00E-11"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0001774|microglial cell activation;GO:0001819|positive regulation of cytokine production;GO:0001932|regulation of protein phosphorylation;GO:0002218|activation of innate immune response;GO:0002224|toll-like receptor signaling pathway;GO:0002639|positive regulation of immunoglobulin production;GO:0002730|regulation of dendritic cell cytokine production;GO:0002755|MyD88-dependent toll-like receptor signaling pathway;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0007252|I-kappaB phosphorylation;GO:0008584|male gonad development;GO:0009615|response to virus;GO:0010508|positive regulation of autophagy;GO:0010628|positive regulation of gene expression;GO:0030277|maintenance of gastrointestinal epithelium;GO:0030890|positive regulation of B cell proliferation;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0032715|negative regulation of interleukin-6 production;GO:0032717|negative regulation of interleukin-8 production;GO:0032722|positive regulation of chemokine production;GO:0032725|positive regulation of granulocyte macrophage colony-stimulating factor production;GO:0032727|positive regulation of interferon-alpha production;GO:0032728|positive regulation of interferon-beta production;GO:0032729|positive regulation of interferon-gamma production;GO:0032733|positive regulation of interleukin-10 production;GO:0032735|positive regulation of interleukin-12 production;GO:0032741|positive regulation of interleukin-18 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0034122|negative regulation of toll-like receptor signaling pathway;GO:0034123|positive regulation of toll-like receptor signaling pathway;GO:0034162|toll-like receptor 9 signaling pathway;GO:0034163|regulation of toll-like receptor 9 signaling pathway;GO:0034165|positive regulation of toll-like receptor 9 signaling pathway;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043410|positive regulation of MAPK cascade;GO:0043507|positive regulation of JUN kinase activity;GO:0045087|innate immune response;GO:0045577|regulation of B cell differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050727|regulation of inflammatory response;GO:0050729|positive regulation of inflammatory response;GO:0050829|defense response to Gram-negative bacterium;GO:0050864|regulation of B cell activation;GO:0050871|positive regulation of B cell activation;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051607|defense response to virus;GO:0051770|positive regulation of nitric-oxide synthase biosynthetic process;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0071222|cellular response to lipopolysaccharide;GO:0071248|cellular response to metal ion;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1901895|negative regulation of calcium-transporting ATPase activity;GO:1902350|cellular response to chloroquine;","GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0005768|endosome;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0032009|early phagosome;GO:0036019|endolysosome;GO:0045335|phagocytic vesicle;","GO:0003953|NAD+ nucleosidase activity;GO:0004888|transmembrane signaling receptor activity;GO:0005149|interleukin-1 receptor binding;GO:0035197|siRNA binding;GO:0038187|pattern recognition receptor activity;GO:0045322|unmethylated CpG binding;","K10161","TLR9, CD289; toll-like receptor 9"]
["ENSRNOG00000009792",0,0.032165219,10,0.645618597,0.049820775,-4.327108714,0.001517056,0.000914253,"down","yes","Zbbx","protein_coding","chr2:159835653-159946932:-","gi|672042716|ref|XP_008759325.1|",3981,0,"PREDICTED: zinc finger B-box domain-containing protein 1 isoform X1 [Rattus norvegicus]","gi|672042715|ref|XM_008761103.1|",2431,0,"PREDICTED: Rattus norvegicus zinc finger, B-box domain containing (Zbbx), transcript variant X1, mRNA","Q0P5X5",654,0,"Zinc finger B-box domain-containing protein 1",".",".",".",".","pfam00643","zf-B_box","B-box zinc finger.","GO:0003341|cilium movement;","GO:0031514|motile cilium;","GO:0008270|zinc ion binding;",".","."]
["ENSRNOG00000023794",0,0.032165219,10,0.645618597,0.049820775,-4.327108714,0.001517056,0.000914253,"down","yes","Mei4","protein_coding","chr8:82765661-82939649:+","gi|157820267|ref|NP_001102848.1|",1993,0,"meiosis-specific protein MEI4-like [Rattus norvegicus]","gi|157820266|ref|NM_001109378.1|",2830,0,"Rattus norvegicus meiotic double-stranded break formation protein 4 (Mei4), mRNA","Q8BRM6",638,0,"Meiosis-specific protein MEI4",".",".",".",".","pfam13971","Mei4","Meiosis-specific protein Mei4. This family of meiosis specific proteins is required for correct meiotic chromosome segregation and recombination. It is required for meiotic DNA double-strand break (DSB) formation.","GO:0006310|DNA recombination;GO:0007129|synapsis;GO:0007283|spermatogenesis;GO:0042138|meiotic DNA double-strand break formation;GO:0048477|oogenesis;","GO:0000800|lateral element;",".",".","."]
["ENSRNOG00000045554",0,0.032165219,10,0.645618597,0.049820775,-4.327108714,0.001517056,0.000914253,"down","yes","Faim2","protein_coding","chr7:130633348-130659168:-","gi|37360156|dbj|BAC98056.1|",1477,0,"mKIAA0950 protein [Mus musculus]","gi|56799424|ref|NM_144756.2|",1486,0,"Rattus norvegicus Fas apoptotic inhibitory molecule 2 (Faim2), mRNA","O88407",572,0,"Protein lifeguard 2","SPCC576.04",68.2,{"v":5e-12,"d":"5.00E-12"},"COG0670","pfam01027","Bax1-I","Inhibitor of apoptosis-promoting Bax1. Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner.","GO:0002931|response to ischemia;GO:0006915|apoptotic process;GO:0007417|central nervous system development;GO:0021549|cerebellum development;GO:0021680|cerebellar Purkinje cell layer development;GO:0021681|cerebellar granular layer development;GO:0021702|cerebellar Purkinje cell differentiation;GO:0043523|regulation of neuron apoptotic process;GO:0043524|negative regulation of neuron apoptotic process;GO:1902042|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:2001234|negative regulation of apoptotic signaling pathway;","GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0045121|membrane raft;GO:0045211|postsynaptic membrane;",".","K24205","TMBIM, LFG; protein lifeguard"]
["ENSRNOG00000046758",0,0.032165219,10,0.645618597,0.049820775,-4.327108714,0.001517056,0.000914253,"down","yes","Tmem217","protein_coding","chr20:7592627-7619111:-","gi|109509869|ref|XP_001078767.1|",1013,{"v":8e-135,"d":"8.00E-135"},"PREDICTED: transmembrane protein 217-like [Rattus norvegicus]","gi|672086048|ref|XM_003751936.3|",751,0,"PREDICTED: Rattus norvegicus hypothetical protein LOC687483 (LOC687483), transcript variant X2, mRNA","Q8N7C4",227,{"v":2E-70,"d":"2.00E-70"},"Transmembrane protein 217",".",".",".",".","pfam15049","DUF4534","Protein of unknown function (DUF4534). This family of proteins is functionally uncharacterized. This family of proteins is found in mammals. Proteins in this family are typically between 170 and 190 amino acids in length. The protein includes the human integral membrane TMEM217 protein.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000062677",0,0.032165219,10,0.645618597,0.049820775,-4.327108714,0.001517056,0.000914253,"down","yes","ENSRNOG00000062677","lncRNA","chr4:147575101-147579347:-",".",".",".",".","gi|78097331|gb|AC159381.10|",160,{"v":3e-76,"d":"3.00E-76"},"Mus musculus 6 BAC RP24-460E4 (Roswell Park Cancer Institute (C57BL/6J Male) Mouse BAC Library) complete sequence",".",".",".",".",".",".",".",".","pfam15024","Glyco_transf_18","Glycosyltransferase family 18. Enzymes belonging to glycosyltransferase family 18 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase) contribute to the creation of branches in complex-type N-glycans. This domain is responsible for the catalytic activity of the enzyme.",".",".",".",".","."]
["ENSRNOG00000063676",0,0.032165219,10,0.645618597,0.049820775,-4.327108714,0.001517056,0.000914253,"down","yes","Lhfpl4","protein_coding","chr4:146313541-146340463:-","gi|281347857|gb|EFB23441.1|",274,{"v":3e-40,"d":"3.00E-40"},"hypothetical protein PANDA_020378, partial [Ailuropoda melanoleuca]","gi|333944071|gb|AC096041.7|",3718,0,"Rattus norvegicus BAC CH230-15A4 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q7TSY2",110,{"v":1e-36,"d":"1.00E-36"},"LHFPL tetraspan subfamily member 4 protein",".",".",".",".","pfam10242","L_HGMIC_fpl","Lipoma HMGIC fusion partner-like protein. This is a group of proteins expressed from a series of genes referred to as Lipoma HGMIC fusion partner-like. The proteins carry four highly conserved transmembrane domains in this entry. In certain instances, eg in LHFPL5, mutations cause deafness in humans and hypospadias, and LHFPL1 is transcribed in six liver tumor cell lines.",".",".",".",".","."]
["ENSRNOG00000067733",0,0.032165219,10,0.645618597,0.049820775,-4.327108714,0.001517056,0.000914253,"down","yes","ENSRNOG00000067733","lncRNA","chr20:3073097-3075671:-",".",".",".",".","gi|46237639|emb|BX883047.1|",269,{"v":5E-137,"d":"5.00E-137"},"Rattus norvegicus chromosome 20, major histocompatibility complex, assembled from 40 BACs, strain Brown Norway (BN/ssNHsd), RT1n haplotype; segment 6/11","O70422",49.7,4e-06,"General transcription factor IIH subunit 4",".",".",".",".","pfam03849","Tfb2","Transcription factor Tfb2.",".",".",".",".","."]
["ENSRNOG00000067746",0,0.032165219,10,0.645618597,0.049820775,-4.327108714,0.001517056,0.000914253,"down","yes","ENSRNOG00000067746","snoRNA","chr6:128656723-128656813:+",".",".",".",".","gi|298892781|emb|FQ211802.1|",84,{"v":4E-35,"d":"4.00E-35"},"Rattus norvegicus TL0AAA79YM06 mRNA sequence",".",".",".",".",".",".",".",".","pfam10228","DUF2228","Uncharacterized conserved protein (DUF2228). This is a family of conserved proteins of approximately 700 residues found from worms to humans.",".",".",".",".","."]
["ENSRNOG00000070345",0,0.032165219,10,0.645618597,0.049820775,-4.327108714,0.001517056,0.000914253,"down","yes","ENSRNOG00000070345","lncRNA","chr14:15007452-15028843:-",".",".",".",".","gi|48675560|gb|AC125233.4|",665,0,"Mus musculus BAC clone RP23-9D24 from chromosome 5, complete sequence",".",".",".",".",".",".",".",".","pfam09179","TilS","TilS substrate binding domain. This domain is found in the tRNA(Ile) lysidine synthetase (TilS) protein.",".",".",".",".","."]
["ENSRNOG00000006200",2,0.128660876,14,0.903866035,0.142345073,-2.812535541,0.001519068,0.000915176,"down","yes","St18","protein_coding","chr5:12584110-12671790:-","gi|77628157|ref|NP_695222.2|",5459,0,"suppression of tumorigenicity 18 protein [Rattus norvegicus]","gi|672051805|ref|XM_008763493.1|",3842,0,"PREDICTED: Rattus norvegicus suppression of tumorigenicity 18 (St18), transcript variant X5, mRNA","Q9QX27",2029,0,"Suppression of tumorigenicity 18 protein",".",".",".",".","pfam08474","MYT1","Myelin transcription factor 1. This domain is found in the myelin transcription factor 1 (MYT1) of chordates. MYT1 contains C2HC zinc finger domains (pfam01530) and is expressed in developing neurons of the central nervous system where it is involved in the selection of neuronal precursor cells.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008285|negative regulation of cell proliferation;GO:0033209|tumor necrosis factor-mediated signaling pathway;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0070102|interleukin-6-mediated signaling pathway;GO:0070498|interleukin-1-mediated signaling pathway;GO:2001269|positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;","GO:0005634|nucleus;GO:0032993|protein-DNA complex;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0008270|zinc ion binding;","K24386","ST18; suppression of tumorigenicity 18 protein"]
["ENSRNOG00000032951",2,0.128660876,14,0.903866035,0.142345073,-2.812535541,0.001519068,0.000915176,"down","yes","Jsrp1","protein_coding","chr7:8901609-8906055:+","gi|157819085|ref|NP_001103061.1|",767,{"v":2E-95,"d":"2.00E-95"},"junctional sarcoplasmic reticulum protein 1 [Rattus norvegicus]","gi|157819084|ref|NM_001109591.1|",1085,0,"Rattus norvegicus junctional sarcoplasmic reticulum protein 1 (Jsrp1), mRNA","Q3MI48",226,{"v":1e-68,"d":"1.00E-68"},"Junctional sarcoplasmic reticulum protein 1",".",".",".",".","pfam15312","JSRP","Junctional sarcoplasmic reticulum protein. JSRP, junctional sarcoplasmic reticulum protein 1, or junctional-face membrane protein of 45 kDa homologue, is a family of eukaryotic proteins. The family is to the junctional face membrane of the skeletal muscle sarcoplasmic reticulum (SR); it colocalizes with its Ca2+-release channel (the ryanodine receptor), and interacts with calsequestrin and the skeletal-muscle dihydro-pyridine receptor Cav1. It is key for the functional expression of voltage-dependent Ca2+ channels.","GO:0003009|skeletal muscle contraction;GO:0060314|regulation of ryanodine-sensitive calcium-release channel activity;GO:0072657|protein localization to membrane;","GO:0016529|sarcoplasmic reticulum;",".",".","."]
["ENSRNOG00000015418",20,1.286608764,45,2.905283684,0.442851337,-1.175105621,1.607004E-3,0.000964998,"down","yes","Klhl14","protein_coding","chr18:12804253-12917828:-","gi|859762833|ref|XP_012906935.1|",3175,0,"PREDICTED: kelch-like protein 14 isoform X1 [Mustela putorius furo]","gi|157820538|ref|NM_001108885.1|",4068,0,"Rattus norvegicus kelch-like family member 14 (Klhl14), mRNA","Q69ZK5",1201,0,"Kelch-like protein 14",".",".",".",".","pfam07707","BACK","BTB And C-terminal Kelch. This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).",".","GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;GO:0015629|actin cytoskeleton;GO:0016235|aggresome;GO:0043005|neuron projection;GO:0043025|neuronal cell body;",".","K10451","KLHL14; kelch-like protein 14"]
["ENSRNOG00000018382",7,0.450313067,24,1.549484632,0.29062119,-1.782788198,0.001656047,0.000993195,"down","yes","Inpp4b","protein_coding","chr19:25925358-26280634:-","gi|16758796|ref|NP_446369.1|",4676,0,"type II inositol 3,4-bisphosphate 4-phosphatase [Rattus norvegicus]","gi|672084693|ref|XM_008772462.1|",4137,0,"PREDICTED: Rattus norvegicus inositol polyphosphate-4-phosphatase, type II (Inpp4b), transcript variant X1, mRNA","Q9QWG5",1733,0,"Type II inositol 3,4-bisphosphate 4-phosphatase",".",".",".",".","pfam07248","DUF1431","Protein of unknown function (DUF1431). This family contains a number of Drosophila melanogaster proteins of unknown function. These contain several conserved cysteine residues.","GO:0006874|cellular calcium ion homeostasis;GO:0008150|biological_process;GO:0036092|phosphatidylinositol-3-phosphate biosynthetic process;GO:0045671|negative regulation of osteoclast differentiation;GO:0046822|regulation of nucleocytoplasmic transport;GO:0046850|regulation of bone remodeling;GO:0046855|inositol phosphate dephosphorylation;GO:0046856|phosphatidylinositol dephosphorylation;GO:0051896|regulation of protein kinase B signaling;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;","GO:0008289|lipid binding;GO:0016316|phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity;GO:0017161|inositol-1,3,4-trisphosphate 4-phosphatase activity;GO:0034593|phosphatidylinositol bisphosphate phosphatase activity;GO:0034594|phosphatidylinositol trisphosphate phosphatase activity;GO:0034597|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity;GO:0052828|inositol-3,4-bisphosphate 4-phosphatase activity;","K01109","INPP4; inositol polyphosphate-4-phosphatase [EC:3.1.3.66]"]
["ENSRNOG00000038066",7,0.450313067,24,1.549484632,0.29062119,-1.782788198,0.001656047,0.000993195,"down","yes","Fam155b","protein_coding","chrX:64925051-64951077:+","gi|109510888|ref|XP_001068528.1|",1961,0,"PREDICTED: transmembrane protein FAM155B [Rattus norvegicus]","gi|672032391|ref|XM_002727573.4|",4144,0,"PREDICTED: Rattus norvegicus family with sequence similarity 155, member B (Fam155b), mRNA","A2BDP1",734,0,"Transmembrane protein FAM155B",".",".",".",".","pfam15266","DUF4594","Domain of unknown function (DUF4594). This protein family is a domain of unknown function. The protein family is found in eukaryotes, and is typically between 170 and 183 amino acids in length.In humans, the gene encoding this protein lies in the position, chromosome 15 open reading frame 52.","GO:0098703|calcium ion import across plasma membrane;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0015275|stretch-activated, cation-selective, calcium channel activity;",".","."]
["ENSRNOG00000031443",6,0.385982629,22,1.420360912,0.271749684,-1.879649737,0.001791954,0.001071105,"down","yes","Havcr2","protein_coding","chr10:30882606-30909137:+","gi|158508553|ref|NP_001094232.1|",1067,{"v":9e-135,"d":"9.00E-135"},"hepatitis A virus cellular receptor 2 homolog precursor [Rattus norvegicus]","gi|158508552|ref|NM_001100762.1|",2763,0,"Rattus norvegicus hepatitis A virus cellular receptor 2 (Havcr2), mRNA","P0C0K5",415,{"v":3e-136,"d":"3.00E-136"},"Hepatitis A virus cellular receptor 2 homolog",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0001819|positive regulation of cytokine production;GO:0002250|adaptive immune response;GO:0002281|macrophage activation involved in immune response;GO:0002519|natural killer cell tolerance induction;GO:0002652|regulation of tolerance induction dependent upon immune response;GO:0002826|negative regulation of T-helper 1 type immune response;GO:0002838|negative regulation of immune response to tumor cell;GO:0002859|negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target;GO:0006954|inflammatory response;GO:0008150|biological_process;GO:0010629|negative regulation of gene expression;GO:0030886|negative regulation of myeloid dendritic cell activation;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0032480|negative regulation of type I interferon production;GO:0032687|negative regulation of interferon-alpha production;GO:0032689|negative regulation of interferon-gamma production;GO:0032703|negative regulation of interleukin-2 production;GO:0032712|negative regulation of interleukin-3 production;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032722|positive regulation of chemokine production;GO:0032729|positive regulation of interferon-gamma production;GO:0032732|positive regulation of interleukin-1 production;GO:0032753|positive regulation of interleukin-4 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032815|negative regulation of natural killer cell activation;GO:0034138|toll-like receptor 3 signaling pathway;GO:0034154|toll-like receptor 7 signaling pathway;GO:0034162|toll-like receptor 9 signaling pathway;GO:0042102|positive regulation of T cell proliferation;GO:0042130|negative regulation of T cell proliferation;GO:0043032|positive regulation of macrophage activation;GO:0045087|innate immune response;GO:0045089|positive regulation of innate immune response;GO:0045824|negative regulation of innate immune response;GO:0050830|defense response to Gram-positive bacterium;GO:0060135|maternal process involved in female pregnancy;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071222|cellular response to lipopolysaccharide;GO:0071656|negative regulation of granulocyte colony-stimulating factor production;GO:1900425|negative regulation of defense response to bacterium;GO:1900426|positive regulation of defense response to bacterium;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:2000521|negative regulation of immunological synapse formation;GO:2001189|negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;","GO:0001772|immunological synapse;GO:0005769|early endosome;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0030054|cell junction;","GO:0003674|molecular_function;GO:0046872|metal ion binding;","K20414","HAVCR2, CD366; hepatitis A virus cellular receptor 2"]
["ENSRNOG00000016136",3,0.192991315,16,1.032989754,0.186827908,-2.420218119,0.001794392,1.072225E-3,"down","yes","Pdcd1lg2","protein_coding","chr1:227158941-227223938:+","gi|255958171|ref|NP_001101052.2|",1344,0,"programmed cell death 1 ligand 2 precursor [Rattus norvegicus]","gi|255958170|ref|NM_001107582.2|",1617,0,"Rattus norvegicus programmed cell death 1 ligand 2 (Pdcd1lg2), mRNA","Q9WUL5",438,{"v":2E-150,"d":"2.00E-150"},"Programmed cell death 1 ligand 2",".",".",".",".","pfam13927","Ig_3","Immunoglobulin domain. This family contains immunoglobulin-like domains.","GO:0006955|immune response;GO:0007166|cell surface receptor signaling pathway;GO:0031295|T cell costimulation;GO:0032689|negative regulation of interferon-gamma production;GO:0032693|negative regulation of interleukin-10 production;GO:0042102|positive regulation of T cell proliferation;GO:0042130|negative regulation of T cell proliferation;GO:0046007|negative regulation of activated T cell proliferation;GO:0071222|cellular response to lipopolysaccharide;","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;",".","K06708","PDCD1LG2, CD273; programmed cell death 1 ligand 2"]
["ENSRNOG00000058810",10,0.643304382,29,1.87229393,0.343591554,-1.54123352,0.00182514,0.001090142,"down","yes","AABR07026305.1","snoRNA","chr16:66502824-66502950:+",".",".",".",".","gi|2267268|gb|AF000144.1|AF000144",127,{"v":7e-59,"d":"7.00E-59"},"Rattus norvegicus fibroblast growth factor receptor 1 gene, alternatively spliced products and partial cds",".",".",".",".",".",".",".",".","pfam13199","Glyco_hydro_66","Glycosyl hydrolase family 66. This family is a set of glycosyl hydrolase enzymes including cycloisomaltooligosaccharide glucanotransferase (EC:2.4.1.-) and dextranase (EC:3.2.1.11) activities.",".",".",".",".","."]
["ENSRNOG00000062810",5,0.321652191,20,1.291237193,0.249103877,-2.005180619,0.001884336,1.123502E-3,"down","yes","ENSRNOG00000062810","protein_coding","chr12:18602770-18606953:-","gi|564323537|ref|XP_003754688.2|",1009,{"v":3e-130,"d":"3.00E-130"},"PREDICTED: LOW QUALITY PROTEIN: paired immunoglobulin-like type 2 receptor beta isoform X1 [Rattus norvegicus]","gi|672033532|ref|XM_003754640.3|",1482,0,"PREDICTED: Rattus norvegicus similar to paired immunoglobin-like type 2 receptor beta (LOC685181), transcript variant X1, mRNA","Q2YFS2",237,{"v":2e-72,"d":"2.00E-72"},"Paired immunoglobulin-like type 2 receptor beta",".",".",".",".","pfam03228","Adeno_VII","Adenoviral core protein VII. The function of this protein is unknown. It has a conserved amino terminus of 50 residues followed by a positively charged tail, suggesting it may interact with nucleic acid. The major core protein of the adenovirus, protein VII, was found to be associated with viral DNA throughout infection. The precursor to protein VII were shown to be in vivo and in vitro acceptors of ADP-ribose. The ADP-ribosylated core proteins were assembled into mature virus particles. ADP-ribosylation of adenovirus core proteins may have a role in virus decapsidation.",".",".",".",".","."]
["ENSRNOG00000001967",4,0.257321753,18,1.162113474,0.221425668,-2.175105621,1.899904E-3,1.131485E-3,"down","yes","Sult1b1","protein_coding","chr14:20492708-20505483:+","gi|3915863|sp|P52847.2|ST1B1_RAT",1554,0,"RecName: Full=Sulfotransferase family cytosolic 1B member 1; Short=ST1B1; Short=Sulfotransferase 1B1; AltName: Full=DOPA/tyrosine sulfotransferase","gi|298903364|emb|FQ209579.1|",1279,0,"Rattus norvegicus TL0ABA41YL20 mRNA sequence","P52847",601,0,"Sulfotransferase family cytosolic 1B member 1",".",".",".",".","pfam00685","Sulfotransfer_1","Sulfotransferase domain.","GO:0006068|ethanol catabolic process;GO:0006805|xenobiotic metabolic process;GO:0008202|steroid metabolic process;GO:0009812|flavonoid metabolic process;GO:0018958|phenol-containing compound metabolic process;GO:0030855|epithelial cell differentiation;GO:0042403|thyroid hormone metabolic process;GO:0050427|3'-phosphoadenosine 5'-phosphosulfate metabolic process;GO:0051923|sulfation;","GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004062|aryl sulfotransferase activity;GO:0008146|sulfotransferase activity;","K01025","SULT1; sulfotransferase [EC:2.8.2.-]"]
["ENSRNOG00000005365",4,0.257321753,18,1.162113474,0.221425668,-2.175105621,1.899904E-3,1.131485E-3,"down","yes","Kcnip1","protein_coding","chr10:18219519-18589045:-","gi|507936571|ref|XP_004679259.1|",1314,{"v":1E-175,"d":"1.00E-175"},"PREDICTED: Kv channel-interacting protein 1 isoform X1 [Condylura cristata]","gi|386869272|ref|NM_001261388.1|",1620,0,"Rattus norvegicus potassium voltage-gated channel interacting protein 1 (Kcnip1), transcript variant 2, mRNA","Q8R426",414,{"v":4e-140,"d":"4.00E-140"},"Kv channel-interacting protein 1","SPAC18B11.04",169,{"v":6e-48,"d":"6.00E-48"},"COG5126","pfam13499","EF-hand_7","EF-hand domain pair.","GO:0045760|positive regulation of action potential;GO:0071805|potassium ion transmembrane transport;GO:1901379|regulation of potassium ion transmembrane transport;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0008076|voltage-gated potassium channel complex;GO:0030425|dendrite;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0034705|potassium channel complex;GO:0043025|neuronal cell body;","GO:0005244|voltage-gated ion channel activity;GO:0005267|potassium channel activity;GO:0005509|calcium ion binding;GO:0015459|potassium channel regulator activity;GO:0044325|ion channel binding;GO:0044877|protein-containing complex binding;GO:0047485|protein N-terminus binding;","K23855","KCNIP; Kv channel-interacting protein"]
["ENSRNOG00000071047",4,0.257321753,18,1.162113474,0.221425668,-2.175105621,1.899904E-3,1.131485E-3,"down","yes","Tnfsf11","protein_coding","chr15:53673877-53705445:-","gi|672078922|ref|XP_008769150.1|",1571,0,"PREDICTED: tumor necrosis factor ligand superfamily member 11 [Rattus norvegicus]","gi|672078921|ref|XM_008770928.1|",2265,0,"PREDICTED: Rattus norvegicus tumor necrosis factor ligand superfamily member 11 (LOC103689974), mRNA","Q9ESE2",606,0,"Tumor necrosis factor ligand superfamily member 11",".",".",".",".","pfam00229","TNF","TNF(tumor Necrosis Factor) family.",".",".",".",".","."]
["ENSRNOG00000003095",1,0.064330438,11,0.710180456,0.090583228,-3.464612238,0.001984594,0.001179094,"down","yes","Fgfbp1","protein_coding","chr14:67104545-67107496:+","gi|564383967|ref|XP_006251140.1|",1170,{"v":1e-157,"d":"1.00E-157"},"PREDICTED: fibroblast growth factor-binding protein 1 isoform X1 [Rattus norvegicus]","gi|672076429|ref|XM_006251078.2|",1220,0,"PREDICTED: Rattus norvegicus fibroblast growth factor binding protein 1 (Fgfbp1), transcript variant X1, mRNA","Q9QY10",454,{"v":1e-158,"d":"1.00E-158"},"Fibroblast growth factor-binding protein 1",".",".",".",".","pfam06473","FGF-BP1","FGF binding protein 1 (FGF-BP1). This family consists of several mammalian FGF binding protein 1. Fibroblast growth factors (FGFs) play important roles during fetal and embryonic development. Fibroblast growth factor-binding protein (FGF-BP) 1 is a secreted protein that can bind fibroblast growth factors (FGFs) 1 and 2.","GO:0007267|cell-cell signaling;GO:0008284|positive regulation of cell proliferation;GO:0045743|positive regulation of fibroblast growth factor receptor signaling pathway;GO:0090050|positive regulation of cell migration involved in sprouting angiogenesis;GO:1903589|positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0009986|cell surface;","GO:0017134|fibroblast growth factor binding;GO:0019838|growth factor binding;","K25535","FGFBP; fibroblast growth factor-binding protein"]
["ENSRNOG00000010603",1,0.064330438,11,0.710180456,0.090583228,-3.464612238,0.001984594,0.001179094,"down","yes","Gzma","protein_coding","chr2:44740569-44752493:-","gi|149059360|gb|EDM10367.1|",1376,0,"granzyme A [Rattus norvegicus]","gi|23618882|ref|NM_153468.1|",771,0,"Rattus norvegicus granzyme A (Gzma), mRNA","P11032",411,{"v":1e-143,"d":"1.00E-143"},"Granzyme A","VC1649",87.4,{"v":2e-18,"d":"2.00E-18"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0009617|response to bacterium;GO:0032078|negative regulation of endodeoxyribonuclease activity;GO:0043065|positive regulation of apoptotic process;GO:0043392|negative regulation of DNA binding;GO:0051354|negative regulation of oxidoreductase activity;GO:0051603|proteolysis involved in cellular protein catabolic process;GO:0070269|pyroptosis;GO:1902483|cytotoxic T cell apoptotic process;","GO:0005634|nucleus;","GO:0004252|serine-type endopeptidase activity;GO:0008236|serine-type peptidase activity;GO:0042803|protein homodimerization activity;","K01352","GZMA; granzyme A [EC:3.4.21.78]"]
["ENSRNOG00000017597",1,0.064330438,11,0.710180456,0.090583228,-3.464612238,0.001984594,0.001179094,"down","yes","Fbp1","protein_coding","chr17:2208031-2230071:+","gi|51036635|ref|NP_036690.2|",1925,0,"fructose-1,6-bisphosphatase 1 [Rattus norvegicus]","gi|158262002|ref|NM_012558.3|",1450,0,"Rattus norvegicus fructose-bisphosphatase 1 (Fbp1), mRNA","P19112",746,0,"Fructose-1,6-bisphosphatase 1","YLR377c",299,{"v":7e-96,"d":"7.00E-96"},"COG0158","pfam00316","FBPase","Fructose-1-6-bisphosphatase.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0005975|carbohydrate metabolic process;GO:0005986|sucrose biosynthetic process;GO:0006000|fructose metabolic process;GO:0006002|fructose 6-phosphate metabolic process;GO:0006094|gluconeogenesis;GO:0006111|regulation of gluconeogenesis;GO:0016311|dephosphorylation;GO:0030308|negative regulation of cell growth;GO:0030388|fructose 1,6-bisphosphate metabolic process;GO:0032869|cellular response to insulin stimulus;GO:0045820|negative regulation of glycolytic process;GO:0046580|negative regulation of Ras protein signal transduction;GO:0071286|cellular response to magnesium ion;GO:0071466|cellular response to xenobiotic stimulus;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0016208|AMP binding;GO:0042132|fructose 1,6-bisphosphate 1-phosphatase activity;GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0048029|monosaccharide binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;","K03841","FBP, fbp; fructose-1,6-bisphosphatase I [EC:3.1.3.11]"]
["ENSRNOG00000025930",1,0.064330438,11,0.710180456,0.090583228,-3.464612238,0.001984594,0.001179094,"down","yes","Chst13","protein_coding","chr4:122824022-122838019:-","gi|300795042|ref|NP_001178903.1|",1755,0,"carbohydrate sulfotransferase 13 precursor [Rattus norvegicus]","gi|564347797|ref|XM_006236870.1|",1610,0,"PREDICTED: Rattus norvegicus carbohydrate (chondroitin 4) sulfotransferase 13 (Chst13), transcript variant X1, mRNA","Q8NET6",499,{"v":5e-172,"d":"5.00E-172"},"Carbohydrate sulfotransferase 13",".",".",".",".","pfam03567","Sulfotransfer_2","Sulfotransferase family. This family includes a variety of sulfotransferase enzymes. Chondroitin 6-sulfotransferase catalyses the transfer of sulfate to position 6 of the N-acetylgalactosamine residue of chondroitin. This family also includes Heparan sulfate 2-O-sulfotransferase (HS2ST) and Heparan sulfate 6-sulfotransferase (HS6ST). Heparan sulfate (HS) is a co-receptor for a number of growth factors, morphogens, and adhesion proteins. HS biosynthetic modifications may determine the strength and outcome of HS-ligand interactions. Mice that lack HS2ST undergo developmental failure only after midgestation,the most dramatic effect being the complete failure of kidney development. Heparan sulphate 6- O -sulfotransferase (HS6ST) catalyses the transfer of sulphate from adenosine 3'-phosphate, 5'-phosphosulphate to the 6th position of the N -sulphoglucosamine residue in heparan sulphate.","GO:0016051|carbohydrate biosynthetic process;GO:0030166|proteoglycan biosynthetic process;GO:0030206|chondroitin sulfate biosynthetic process;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0001537|N-acetylgalactosamine 4-O-sulfotransferase activity;GO:0008146|sulfotransferase activity;GO:0047756|chondroitin 4-sulfotransferase activity;","K07779","CHST13; chondroitin 4-sulfotransferase 13 [EC:2.8.2.5]"]
["ENSRNOG00000032224",1,0.064330438,11,0.710180456,0.090583228,-3.464612238,0.001984594,0.001179094,"down","yes","ENSRNOG00000032224","protein_coding","chr2:183825994-183832048:-","gi|625285956|ref|XP_007634698.1|",429,{"v":7e-49,"d":"7.00E-49"},"PREDICTED: LOW QUALITY PROTEIN: histone H4 isoform X2 [Cricetulus griseus]","gi|183986772|ref|NM_001123469.1|",396,0,"Rattus norvegicus histone cluster 2, H4 (Hist2h4), mRNA","Q28DR4",164,{"v":2e-48,"d":"2.00E-48"},"Histone H4",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.","GO:0001503|ossification;GO:0006334|nucleosome assembly;GO:0006335|DNA replication-dependent nucleosome assembly;GO:0006336|DNA replication-independent nucleosome assembly;GO:0006352|DNA-templated transcription, initiation;GO:0030154|cell differentiation;GO:0045653|negative regulation of megakaryocyte differentiation;","GO:0000228|nuclear chromosome;GO:0000786|nucleosome;GO:0005576|extracellular region;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0032991|protein-containing complex;","GO:0019904|protein domain specific binding;GO:0046982|protein heterodimerization activity;","K11254","H4; histone H4"]
["ENSRNOG00000021334",26,1.672591393,53,3.421778562,0.488807608,-1.032661356,0.002043976,0.00121223,"down","yes","Lag3","protein_coding","chr4:157712667-157720404:-","gi|61889117|ref|NP_997678.2|",2198,0,"lymphocyte activation gene 3 protein precursor [Rattus norvegicus]","gi|61889116|ref|NM_212513.2|",1790,0,"Rattus norvegicus lymphocyte activating 3 (Lag3), mRNA","Q5BK54",851,0,"Lymphocyte activation gene 3 protein",".",".",".",".","pfam13927","Ig_3","Immunoglobulin domain. This family contains immunoglobulin-like domains.","GO:0002250|adaptive immune response;GO:0002270|plasmacytoid dendritic cell activation;GO:0007166|cell surface receptor signaling pathway;GO:0032703|negative regulation of interleukin-2 production;GO:0045590|negative regulation of regulatory T cell differentiation;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;GO:0050776|regulation of immune response;GO:0050868|negative regulation of T cell activation;","GO:0005576|extracellular region;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0004888|transmembrane signaling receptor activity;GO:0042289|MHC class II protein binding;","K06565","LAG3, CD223; lymphocyte-activation gene 3 protein"]
["ENSRNOG00000004458",9,0.578973944,27,1.743170211,0.332138503,-1.59014312,0.002089894,0.001237792,"down","yes","Ston2","protein_coding","chr6:110567485-110676376:-","gi|209529642|ref|NP_001129346.1|",4585,0,"stonin-2 [Rattus norvegicus]","gi|672056611|ref|XM_006240407.2|",3185,0,"PREDICTED: Rattus norvegicus stonin 2 (Ston2), transcript variant X2, mRNA","D4AB66",1766,0,"Stonin-2",".",".",".",".","pfam12016","Stonin2_N","Stonin 2. Stonin 2 is involved in clathrin mediated endocytosis. It binds to Eps15 by its highly conserved NPF motif. The complex formed has been shown to directly associate with the clathrin adaptor complex AP-2, and to localize to clathrin-coated pits (CCPs). In addition, stonin2 was recently identified as a specific sorting adaptor for synaptotagmin, and may thus regulate synaptic vesicle recycling.","GO:0002244|hematopoietic progenitor cell differentiation;GO:0016192|vesicle-mediated transport;GO:0030100|regulation of endocytosis;GO:0048488|synaptic vesicle endocytosis;","GO:0005730|nucleolus;GO:0005829|cytosol;GO:0008021|synaptic vesicle;GO:0016020|membrane;GO:0030136|clathrin-coated vesicle;GO:0031410|cytoplasmic vesicle;GO:0043005|neuron projection;GO:0098793|presynapse;","GO:0005515|protein binding;GO:0035615|clathrin adaptor activity;","K20067","STON1_2; stonin-1/2"]
["ENSRNOG00000063848",18,1.157947887,41,2.647036246,0.437450711,-1.192807623,0.002310124,0.001362436,"down","yes","ENSRNOG00000063848","protein_coding","chr9:74231751-74237923:-","gi|672027568|ref|XP_008762237.1|",1460,0,"PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC102547825 isoform X1, partial [Rattus norvegicus]","gi|388240416|dbj|AP012456.1|",2704,0,"Rattus norvegicus DNA, BAC clone: RNB1-385K15, strain: F344/Stm, complete sequence","P03355",439,0,"Gag-Pol polyprotein",".",".",".",".","pfam02093","Gag_p30","Gag P30 core shell protein. According to Swiss-Prot annotation this protein is the viral core shell protein. P30 is essential for viral assembly.",".",".",".",".","."]
["ENSRNOG00000067556",11,0.70763482,30,1.93685579,0.365352353,-1.452639596,0.002408773,0.00141725,"down","yes","ENSRNOG00000067556","lncRNA","chr1:243438450-243442581:+","gi|696994985|ref|XP_009564302.1|",141,{"v":3E-11,"d":"3.00E-11"},"PREDICTED: LOW QUALITY PROTEIN: RNA-directed DNA polymerase from mobile element jockey-like, partial [Cuculus canorus]","gi|30270591|gb|AC103018.7|",554,0,"Rattus norvegicus 1 CH230-196F22 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam09492","Pec_lyase","Pectic acid lyase. Members of this family are isozymes of pectate lyase (EC:4.2.2.2), also called polygalacturonic transeliminase and alpha-1,4-D-endopolygalacturonic acid lyase.",".",".",".",".","."]
["ENSRNOG00000003681",2,0.128660876,13,0.839304176,0.153294694,-2.705620337,0.002749152,0.00160923,"down","yes","Lct","protein_coding","chr13:39781929-39824456:-","gi|281306775|ref|NP_446293.1|",10209,0,"lactase-phlorizin hydrolase preproprotein [Rattus norvegicus]","gi|281306774|ref|NM_053841.1|",6117,0,"Rattus norvegicus lactase (Lct), mRNA","Q02401",3822,0,"Lactase-phlorizin hydrolase","BH1923",305,{"v":7e-90,"d":"7.00E-90"},"COG2723","pfam00232","Glyco_hydro_1","Glycosyl hydrolase family 1.","GO:0001666|response to hypoxia;GO:0005975|carbohydrate metabolic process;GO:0007584|response to nutrient;GO:0009410|response to xenobiotic stimulus;GO:0009725|response to hormone;GO:0009744|response to sucrose;GO:0010033|response to organic substance;GO:0010040|response to iron(II) ion;GO:0010045|response to nickel cation;GO:0010288|response to lead ion;GO:0042594|response to starvation;GO:0043627|response to estrogen;GO:0045471|response to ethanol;","GO:0005783|endoplasmic reticulum;GO:0005903|brush border;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;","GO:0000016|lactase activity;GO:0004553|hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0008422|beta-glucosidase activity;GO:0016740|transferase activity;GO:0017042|glycosylceramidase activity;","K01229","LCT; lactase-phlorizin hydrolase [EC:3.2.1.108 3.2.1.62]"]
["ENSRNOG00000024330",2,0.128660876,13,0.839304176,0.153294694,-2.705620337,0.002749152,0.00160923,"down","yes","Ngp","protein_coding","chr8:110394203-110397570:+","gi|157821823|ref|NP_001100332.1|",779,{"v":3e-100,"d":"3.00E-100"},"neutrophilic granule protein precursor [Rattus norvegicus]","gi|157821822|ref|NM_001106862.1|",1099,0,"Rattus norvegicus neutrophilic granule protein (Ngp), mRNA","O08692",214,{"v":1e-66,"d":"1.00E-66"},"Neutrophilic granule protein",".",".",".",".","pfam00666","Cathelicidins","Cathelicidin. A novel protein family, showing a conserved proregion and a variable carboxyl-terminal antimicrobial domain. This region shows similarity to cystatins.","GO:0006952|defense response;GO:0010951|negative regulation of endopeptidase activity;","GO:0005615|extracellular space;","GO:0004869|cysteine-type endopeptidase inhibitor activity;",".","."]
["ENSRNOG00000069352",2,0.128660876,13,0.839304176,0.153294694,-2.705620337,0.002749152,0.00160923,"down","yes","ENSRNOG00000069352","protein_coding","chr2:175403263-175406815:-","gi|564300584|ref|XP_006224243.1|",1360,0,"PREDICTED: aquaporin-10 isoform X1 [Rattus norvegicus]","gi|672015987|ref|XM_006224181.2|",769,0,"PREDICTED: Rattus norvegicus similar to aquaporin 10 (LOC686596), transcript variant X1, mRNA","Q96PS8",459,{"v":1E-161,"d":"1.00E-161"},"Aquaporin-10","PA3581",156,{"v":3e-44,"d":"3.00E-44"},"COG0580","pfam00230","MIP","Major intrinsic protein. MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.",".",".",".",".","."]
["ENSRNOG00000001315",0,0.032165219,9,0.581056737,0.055356417,-4.175105621,0.002878278,0.001676909,"down","yes","ENSRNOG00000001315","protein_coding","chr20:13629000-13703449:+","gi|564397589|ref|XP_006256402.1|",1042,{"v":7e-131,"d":"7.00E-131"},"PREDICTED: rhabdoid tumor deletion region protein 1 isoform X1 [Rattus norvegicus]","gi|672086276|ref|XM_006256341.2|",671,0,"PREDICTED: Rattus norvegicus rhabdoid tumor deletion region gene 1 (Rtdr1), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam00503","G-alpha","G-protein alpha subunit. G proteins couple receptors of extracellular signals to intracellular signaling pathways. The G protein alpha subunit binds guanyl nucleotide and is a weak GTPase. A set of residues that are unique to G-alpha as compared to its ancestor the Arf-like family form a ring of residues centered on the nucleotide binding site. A Ggamma is found fused to an inactive Galpha in the Dictyostelium protein gbqA.",".",".",".","K25459","RSPH14, RTDR1; radial spoke head protein 14"]
["ENSRNOG00000007575",0,0.032165219,9,0.581056737,0.055356417,-4.175105621,0.002878278,0.001676909,"down","yes","Plppr1","protein_coding","chr5:63437816-63763835:+","gi|41152510|ref|NP_958428.1|",1725,0,"phospholipid phosphatase-related protein type 1 [Rattus norvegicus]","gi|41152509|ref|NM_201271.1|",1028,0,"Rattus norvegicus phospholipid phosphatase related 1 (Plppr1), mRNA","Q6WAY2",669,0,"Phospholipid phosphatase-related protein type 1",".",".",".",".","pfam01569","PAP2","PAP2 superfamily. This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidizing halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.","GO:0006644|phospholipid metabolic process;GO:0007165|signal transduction;GO:0007399|nervous system development;GO:0016311|dephosphorylation;GO:0046839|phospholipid dephosphorylation;","GO:0005654|nucleoplasm;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;","GO:0008195|phosphatidate phosphatase activity;GO:0042577|lipid phosphatase activity;","K19581","LPPR1_2_5; lipid phosphate phosphatase-related protein type 1/2/5"]
["ENSRNOG00000008737",0,0.032165219,9,0.581056737,0.055356417,-4.175105621,0.002878278,0.001676909,"down","yes","Tbc1d21","protein_coding","chr8:58761563-58773711:-","gi|62079147|ref|NP_001014232.1|",1799,0,"TBC1 domain family member 21 [Rattus norvegicus]","gi|62079146|ref|NM_001014210.1|",1218,0,"Rattus norvegicus TBC1 domain family, member 21 (Tbc1d21), mRNA","Q9D9D3",655,0,"TBC1 domain family member 21","SPAC630.05",91.7,{"v":5e-19,"d":"5.00E-19"},"COG5210","pfam00566","RabGAP-TBC","Rab-GTPase-TBC domain. Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.","GO:0006886|intracellular protein transport;GO:0090630|activation of GTPase activity;","GO:0001669|acrosomal vesicle;","GO:0003779|actin binding;GO:0005096|GTPase activator activity;","K24798","TBC1D21; TBC1 domain family member 21"]
["ENSRNOG00000020276",0,0.032165219,9,0.581056737,0.055356417,-4.175105621,0.002878278,0.001676909,"down","yes","Tnni2","protein_coding","chr1:197594813-197597560:+","gi|355566185|gb|EHH22564.1|",872,{"v":7e-113,"d":"7.00E-113"},"Troponin I, fast-twitch isoform, partial [Macaca mulatta]","gi|298889559|emb|FQ217454.1|",635,0,"Rattus norvegicus TL0ACA25YO07 mRNA sequence","P27768",335,{"v":3e-112,"d":"3.00E-112"},"Troponin I, fast skeletal muscle",".",".",".",".","pfam00992","Troponin","Troponin. Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). this Pfam contains members of the TnT subunit. Troponin is a complex of three proteins, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). The troponin complex regulates Ca++ induced muscle contraction. This family includes troponin T and troponin I. Troponin I binds to actin and troponin T binds to tropomyosin.","GO:0003009|skeletal muscle contraction;GO:0006936|muscle contraction;GO:0006937|regulation of muscle contraction;GO:0045893|positive regulation of transcription, DNA-templated;GO:0060048|cardiac muscle contraction;","GO:0005634|nucleus;GO:0005861|troponin complex;","GO:0003674|molecular_function;GO:0003779|actin binding;GO:0031014|troponin T binding;","K12043","TNNI2; troponin I, fast skeletal muscle"]
["ENSRNOG00000046494",0,0.032165219,9,0.581056737,0.055356417,-4.175105621,0.002878278,0.001676909,"down","yes","ENSRNOG00000046494","protein_coding","chr20:28336101-28336487:+","gi|564322180|ref|XP_006223963.1|",540,{"v":2e-68,"d":"2.00E-68"},"PREDICTED: uncharacterized protein C10orf105 homolog isoform X2 [Rattus norvegicus]","gi|672031773|ref|XM_006223903.2|",387,0,"PREDICTED: Rattus norvegicus rCG22048-like (LOC100361018), transcript variant X3, mRNA","Q8TEF2",129,{"v":2e-37,"d":"2.00E-37"},"Uncharacterized protein C10orf105",".",".",".",".","pfam05134","T2SL","Type II secretion system (T2SS), protein L. This family consists of Type II secretion system protein L sequences from several Gram-negative (diderm) bacteria. The Type II secretion system, also called Secretion-dependent pathway (SDP), is responsible for extracellular secretion of a number of different proteins, including proteases and toxins. This pathway supports secretion of proteins across the cell envelope in two distinct steps, in which the second step, involving translocation through the outer membrane, is assisted by at least 13 different gene products. T2SL is predicted to contain a large cytoplasmic domain represented by this family and has been shown to interact with the autophosphorylating cytoplasmic membrane protein T2SE. It is thought that the tri-molecular complex of T2SL, T2SE (pfam00437) and T2SM (pfam04612) might be involved in regulating the opening and closing of the secretion pore and/or transducing energy to the site of outer membrane translocation.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000051970",0,0.032165219,9,0.581056737,0.055356417,-4.175105621,0.002878278,0.001676909,"down","yes","Aqp5","protein_coding","chr7:130721748-130726209:+","gi|50926839|gb|AAH78904.1|",1139,{"v":1E-146,"d":"1.00E-146"},"Aqp5 protein, partial [Rattus norvegicus]","gi|82414786|gb|BC110045.1|",1428,0,"Rattus norvegicus aquaporin 5, mRNA (cDNA clone MGC:124967 IMAGE:7100092), complete cds","P47864",424,{"v":2e-141,"d":"2.00E-141"},"Aquaporin-5","SMc01870",115,{"v":2e-27,"d":"2.00E-27"},"COG0580","pfam00230","MIP","Major intrinsic protein. MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.","GO:0006833|water transport;GO:0015670|carbon dioxide transport;GO:0030157|pancreatic juice secretion;GO:0042476|odontogenesis;GO:0046541|saliva secretion;GO:0048593|camera-type eye morphogenesis;GO:0051289|protein homotetramerization;GO:0055085|transmembrane transport;GO:0071476|cellular hypotonic response;","GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005902|microvillus;GO:0009925|basal plasma membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0030659|cytoplasmic vesicle membrane;","GO:0015250|water channel activity;GO:0042802|identical protein binding;","K09867","AQP5; aquaporin-5"]
["ENSRNOG00000054953",0,0.032165219,9,0.581056737,0.055356417,-4.175105621,0.002878278,0.001676909,"down","yes","Pcdhb6","pseudogene","chr18:29046383-29048717:+","gi|62339322|ref|NP_001014780.1|",3733,0,"protocadherin beta 6 precursor [Rattus norvegicus]","gi|167860092|ref|NM_001014780.2|",2331,0,"Rattus norvegicus protocadherin beta 6 (Pcdhb6), mRNA","Q91XZ4",1309,0,"Protocadherin beta-6",".",".",".",".","pfam08266","Cadherin_2","Cadherin-like. This cadherin domain is usually the most N-terminal copy of the domain.","GO:0008150|biological_process;","GO:0005575|cellular_component;","GO:0003674|molecular_function;","K16494","PCDHB; protocadherin beta"]
["ENSRNOG00000069868",0,0.032165219,9,0.581056737,0.055356417,-4.175105621,0.002878278,0.001676909,"down","yes","ENSRNOG00000069868","protein_coding","chr6:136250562-136251132:-","gi|1929922|gb|AAB51478.1|",588,{"v":2e-74,"d":"2.00E-74"},"anti-idiotype immunoglobulin M heavy chain [Rattus norvegicus]","gi|1929921|gb|U75412.1|RNU75412",373,0,"Rattus norvegicus anti-idiotype immunoglobulin M heavy chain gene, partial cds","P01746",186,{"v":5e-59,"d":"5.00E-59"},"Ig heavy chain V region 93G7",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000070055",0,0.032165219,9,0.581056737,0.055356417,-4.175105621,0.002878278,0.001676909,"down","yes","ENSRNOG00000070055","protein_coding","chr17:42696791-42697295:+","gi|392354394|ref|XP_003751759.1|",550,{"v":3e-69,"d":"3.00E-69"},"PREDICTED: histone H2A type 1-like [Rattus norvegicus]","gi|672082126|ref|XM_003751711.3|",505,0,"PREDICTED: Rattus norvegicus histone H2A type 1-like (LOC100910554), transcript variant X2, mRNA","Q4FZT6",211,{"v":2e-68,"d":"2.00E-68"},"Histone H2A type 3","SPAC19G12.06c",177,{"v":7e-56,"d":"7.00E-56"},"COG5262","pfam00125","Histone","Core histone H2A/H2B/H3/H4.",".",".",".",".","."]
["ENSRNOG00000017773",6,0.385982629,21,1.355799053,0.284690145,-1.812535541,0.002916617,0.001698206,"down","yes","Crispld1","protein_coding","chr5:1274647-1314926:-","gi|795140840|ref|XP_011792562.1|",2668,0,"PREDICTED: cysteine-rich secretory protein LCCL domain-containing 1 isoform X1 [Colobus angolensis palliatus]","gi|201066377|ref|NM_001134963.1|",4433,0,"Rattus norvegicus cysteine-rich secretory protein LCCL domain containing 1 (Crispld1), mRNA","Q8CGD2",997,0,"Cysteine-rich secretory protein LCCL domain-containing 1","YJL078c_1",51.2,3e-06,"COG2340","pfam03815","LCCL","LCCL domain.","GO:0060325|face morphogenesis;GO:0061484|hematopoietic stem cell homeostasis;","GO:0005615|extracellular space;",".","K24243","CRISPLD; cysteine-rich secretory protein LCCL domain-containing"]
["ENSRNOG00000050091",12,0.771965258,31,2.001417649,0.385709229,-1.374414429,3.091884E-3,1.79349E-3,"down","yes","Efcab1","protein_coding","chr11:85983304-85996538:-","gi|157817833|ref|NP_001100400.1|",1048,{"v":1E-139,"d":"1.00E-139"},"EF-hand calcium-binding domain-containing protein 1 [Rattus norvegicus]","gi|157817832|ref|NM_001106930.1|",1198,0,"Rattus norvegicus EF hand calcium binding domain 1 (Efcab1), mRNA","Q9D3N2",389,{"v":1e-133,"d":"1.00E-133"},"EF-hand calcium-binding domain-containing protein 1","YKL190w",77.4,{"v":8e-16,"d":"8.00E-16"},"COG5126","pfam13499","EF-hand_7","EF-hand domain pair.",".",".","GO:0005509|calcium ion binding;",".","."]
["ENSRNOG00000032375",3,0.192991315,15,0.968427895,0.199283102,-2.327108714,0.003135443,1.816175E-3,"down","yes","Capn13","protein_coding","chr6:22071845-22166850:+","gi|68341951|ref|NP_001020304.1|",3523,0,"calpain-13 [Rattus norvegicus]","gi|68341950|ref|NM_001025133.1|",2573,0,"Rattus norvegicus calpain 13 (Capn13), mRNA","Q5BK10",1361,0,"Calpain-13",".",".",".",".","pfam00648","Peptidase_C2","Calpain family cysteine protease.","GO:0006508|proteolysis;GO:0043066|negative regulation of apoptotic process;","GO:0005737|cytoplasm;","GO:0004198|calcium-dependent cysteine-type endopeptidase activity;GO:0005509|calcium ion binding;","K08581","CAPN13; calpain-13 [EC:3.4.22.-]"]
["ENSRNOG00000043323",3,0.192991315,15,0.968427895,0.199283102,-2.327108714,0.003135443,1.816175E-3,"down","yes","ENSRNOG00000043323","protein_coding","chr3:7021973-7031619:-","gi|564339567|ref|XP_006233676.1|",968,{"v":2e-129,"d":"2.00E-129"},"PREDICTED: interleukin-36 beta isoform X1 [Rattus norvegicus]","gi|672044682|ref|XM_006233617.2|",943,0,"PREDICTED: Rattus norvegicus interleukin 36, beta (Il36b), transcript variant X3, mRNA","Q9D6Z6",272,{"v":1E-89,"d":"1.00E-89"},"Interleukin-36 beta",".",".",".",".","pfam00340","IL1","Interleukin-1 / 18. This family includes interleukin-1 and interleukin-18.","GO:0001819|positive regulation of cytokine production;GO:0002437|inflammatory response to antigenic stimulus;GO:0006954|inflammatory response;GO:0010628|positive regulation of gene expression;GO:0019221|cytokine-mediated signaling pathway;GO:0032755|positive regulation of interleukin-6 production;GO:0045582|positive regulation of T cell differentiation;GO:0071222|cellular response to lipopolysaccharide;","GO:0005615|extracellular space;","GO:0005125|cytokine activity;GO:0005149|interleukin-1 receptor binding;","K05486","IL36B, IL1F8; interleukin 36 beta"]
["ENSRNOG00000016472",4,0.257321753,17,1.097551614,0.234450708,-2.092643461,0.003226144,0.001867576,"down","yes","Marchf4","protein_coding","chr9:74078434-74198199:-","gi|109486240|ref|XP_001074008.1|",1608,0,"PREDICTED: E3 ubiquitin-protein ligase MARCH4 [Rattus norvegicus]","gi|672024147|ref|XM_001055311.4|",2813,0,"PREDICTED: Rattus norvegicus membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase (March4), transcript variant X1, mRNA","Q80TE3",611,0,"E3 ubiquitin-protein ligase MARCH4","YIL030c",55.8,1e-06,"COG5183","pfam12906","RINGv","RING-variant domain.","GO:0016567|protein ubiquitination;","GO:0005795|Golgi stack;GO:0005802|trans-Golgi network;GO:0016021|integral component of membrane;","GO:0004842|ubiquitin-protein transferase activity;GO:0008270|zinc ion binding;","K10659","MARCH4_9_11; E3 ubiquitin-protein ligase MARCH4/9/11 [EC:2.3.2.27]"]
["ENSRNOG00000022868",14,0.900626135,34,2.195103228,0.410288739,-1.285288539,0.00325595,1.882732E-3,"down","yes","Ell3","protein_coding","chr3:108410448-108417132:-","gi|564342552|ref|XP_006234893.1|",1961,0,"PREDICTED: RNA polymerase II elongation factor ELL3 isoform X1 [Rattus norvegicus]","gi|672046797|ref|XM_006234831.2|",2906,0,"PREDICTED: Rattus norvegicus elongation factor RNA polymerase II-like 3 (Ell3), transcript variant X1, mRNA","Q5XFX8",741,0,"RNA polymerase II elongation factor ELL3",".",".",".",".","pfam10390","ELL","RNA polymerase II elongation factor ELL. ELL is a family of RNA polymerase II elongation factors. It is bound stably to elongation-associated factors 1 and 2, EAFs, and together these act as a strong regulator of transcription activity. by direct interaction with Pol II. ELL binds to pol II on its own but the affinity is greatly increased by the cooperation of EAF. Some members carry an Occludin domain pfam07303 just downstream. There is no S. cerevisiae member.","GO:0006354|DNA-templated transcription, elongation;GO:0006366|transcription by RNA polymerase II;GO:0006368|transcription elongation from RNA polymerase II promoter;GO:0008150|biological_process;GO:0010717|regulation of epithelial to mesenchymal transition;GO:0032786|positive regulation of DNA-templated transcription, elongation;GO:0042795|snRNA transcription by RNA polymerase II;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048863|stem cell differentiation;GO:0050769|positive regulation of neurogenesis;GO:1901797|negative regulation of signal transduction by p53 class mediator;GO:1902166|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:2000179|positive regulation of neural precursor cell proliferation;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005694|chromosome;GO:0005730|nucleolus;GO:0005829|cytosol;GO:0008023|transcription elongation factor complex;GO:0016607|nuclear speck;GO:0030054|cell junction;","GO:0000987|proximal promoter sequence-specific DNA binding;GO:0003674|molecular_function;","K15183","ELL; RNA polymerase II elongation factor ELL"]
["ENSRNOG00000064076",16,1.029287011,37,2.388788807,0.430882382,-1.214633985,0.003318881,0.001916986,"down","yes","ENSRNOG00000064076","lncRNA","chr3:68765037-68766837:+",".",".",".",".","gi|23304112|emb|AL844166.6|",379,0,"Mouse DNA sequence from clone RP23-107K21 on chromosome 2, complete sequence",".",".",".",".",".",".",".",".","pfam10441","Urb2","Urb2/Npa2 family. This family includes the Urb2 protein from yeast that are involved in ribosome biogenesis.",".",".",".",".","."]
["ENSRNOG00000066951",16,1.029287011,37,2.388788807,0.430882382,-1.214633985,0.003318881,0.001916986,"down","yes","ENSRNOG00000066951","lncRNA","chr4:59661159-59662945:+",".",".",".",".","gi|66796238|gb|AC153820.4|",483,0,"Mus musculus 6 BAC RP23-459L15 (Roswell Park Cancer Institute (C57BL/6J Female) Mouse BAC Library) complete sequence",".",".",".",".",".",".",".",".","pfam15546","DUF4653","Domain of unknown function (DUF4653). This family of proteins is found in eukaryotes. Proteins in this family are typically between 93 and 229 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000017528",11,0.70763482,29,1.87229393,0.37795071,-1.403729996,0.003641542,0.002095514,"down","yes","Gpr157","protein_coding","chr5:160550713-160566432:+","gi|58865784|ref|NP_001012107.1|",1364,{"v":5e-180,"d":"5.00E-180"},"probable G-protein coupled receptor 157 [Rattus norvegicus]","gi|58865783|ref|NM_001012107.1|",2337,0,"Rattus norvegicus G protein-coupled receptor 157 (Gpr157), mRNA","Q5FVG1",530,0,"G-protein coupled receptor 157",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0007166|cell surface receptor signaling pathway;GO:0007186|G protein-coupled receptor signaling pathway;GO:0048512|circadian behavior;GO:0051482|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway;GO:0060019|radial glial cell differentiation;","GO:0016021|integral component of membrane;GO:0060170|ciliary membrane;","GO:0004930|G protein-coupled receptor activity;","K08467","GPR157; G protein-coupled receptor 157"]
["ENSRNOG00000009771",1,0.064330438,10,0.645618597,0.099641551,-3.327108714,0.003733229,0.00214417,"down","yes","Cdh10","protein_coding","chr2:68628780-68850995:+","gi|274323706|ref|NP_001162102.1|",4005,0,"cadherin-10 precursor [Rattus norvegicus]","gi|274323705|ref|NM_001168631.1|",3169,0,"Rattus norvegicus cadherin 10 (Cdh10), mRNA","P70408",1534,0,"Cadherin-10",".",".",".",".","pfam01049","Cadherin_C","Cadherin cytoplasmic region. Cadherins are vital in cell-cell adhesion during tissue differentiation. Cadherins are linked to the cytoskeleton by catenins. Catenins bind to the cytoplasmic tail of the cadherin. Cadherins cluster to form foci of homophilic binding units. A key determinant to the strength of the binding that it is mediated by cadherins is the juxtamembrane region of the cadherin. This region induces clustering and also binds to the protein p120ctn.","GO:0000902|cell morphogenesis;GO:0007043|cell-cell junction assembly;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007275|multicellular organism development;GO:0016339|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0034332|adherens junction organization;GO:0098609|cell-cell adhesion;GO:0098742|cell-cell adhesion via plasma-membrane adhesion molecules;","GO:0005912|adherens junction;GO:0016342|catenin complex;GO:0098978|glutamatergic synapse;GO:0098982|GABA-ergic synapse;GO:0099059|integral component of presynaptic active zone membrane;GO:0099060|integral component of postsynaptic specialization membrane;","GO:0005509|calcium ion binding;GO:0045296|cadherin binding;","K06802","CDH10; cadherin 10, type 2, T2-cadherin"]
["ENSRNOG00000064858",1,0.064330438,10,0.645618597,0.099641551,-3.327108714,0.003733229,0.00214417,"down","yes","ENSRNOG00000064858","lncRNA","chr5:4351878-4359233:+",".",".",".",".","gi|20339144|emb|AL669975.9|",66,{"v":1e-23,"d":"1.00E-23"},"Mouse DNA sequence from clone RP23-218H24 on chromosome X, complete sequence",".",".",".",".",".",".",".",".","pfam09082","DUF1922","Domain of unknown function (DUF1922). Members of this family consist of a beta-sheet region followed by an alpha-helix and an unstructured C-terminus. The beta-sheet region contains a CXCX...XCXC sequence with Cys residues located in two proximal loops and pointing towards each other. This precise function of this set of bacterial proteins is, as yet, unknown.",".",".",".",".","."]
["ENSRNOG00000013042",13,0.836295696,32,2.065979509,0.4047938,-1.304740901,0.003876055,0.002221287,"down","yes","Htr1b","protein_coding","chr8:82517360-82534549:-","gi|11560016|ref|NP_071561.1|",1960,0,"5-hydroxytryptamine receptor 1B [Rattus norvegicus]","gi|202542|gb|M89954.1|RAT5HT1BR",1545,0,"Rattus norvegicus 5-HT1B serotonin receptor gene, complete cds","P28564",759,0,"5-hydroxytryptamine receptor 1B",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0002031|G protein-coupled receptor internalization;GO:0007187|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007193|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007198|adenylate cyclase-inhibiting serotonin receptor signaling pathway;GO:0007205|protein kinase C-activating G protein-coupled receptor signaling pathway;GO:0007268|chemical synaptic transmission;GO:0007631|feeding behavior;GO:0009636|response to toxic substance;GO:0014053|negative regulation of gamma-aminobutyric acid secretion;GO:0014059|regulation of dopamine secretion;GO:0014063|negative regulation of serotonin secretion;GO:0032229|negative regulation of synaptic transmission, GABAergic;GO:0042220|response to cocaine;GO:0042310|vasoconstriction;GO:0042756|drinking behavior;GO:0045471|response to ethanol;GO:0046849|bone remodeling;GO:0050795|regulation of behavior;GO:0051385|response to mineralocorticoid;GO:0051967|negative regulation of synaptic transmission, glutamatergic;GO:0071312|cellular response to alkaloid;GO:0071466|cellular response to xenobiotic stimulus;GO:0071502|cellular response to temperature stimulus;GO:0099171|presynaptic modulation of chemical synaptic transmission;GO:0099509|regulation of presynaptic cytosolic calcium ion concentration;GO:1904707|positive regulation of vascular smooth muscle cell proliferation;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0030425|dendrite;GO:0044305|calyx of Held;GO:0098666|G protein-coupled serotonin receptor complex;GO:0099056|integral component of presynaptic membrane;GO:0099154|serotonergic synapse;","GO:0004993|G protein-coupled serotonin receptor activity;GO:0030594|neurotransmitter receptor activity;GO:0051378|serotonin binding;GO:0099626|voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels;GO:1901363|heterocyclic compound binding;","K04153","HTR1; 5-hydroxytryptamine receptor 1"]
["ENSRNOG00000006814",10,0.643304382,27,1.743170211,0.369042781,-1.438140027,0.004272856,0.002436219,"down","yes","Klrg2","protein_coding","chr4:67363919-67374147:-","gi|293346733|ref|XP_002726391.1|",1706,0,"PREDICTED: killer cell lectin-like receptor subfamily G member 2 isoform X1 [Rattus norvegicus]","gi|672018159|ref|XM_002726345.3|",2175,0,"PREDICTED: Rattus norvegicus killer cell lectin-like receptor subfamily G, member 2 (Klrg2), transcript variant X1, mRNA","Q3UM83",569,0,"Killer cell lectin-like receptor subfamily G member 2",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000056493",10,0.643304382,27,1.743170211,0.369042781,-1.438140027,0.004272856,0.002436219,"down","yes","Mybpc1","protein_coding","chr7:22930350-23015957:-","gi|672058260|ref|XP_008763469.1|",5825,0,"PREDICTED: myosin-binding protein C, slow-type isoform X2 [Rattus norvegicus]","gi|692110331|ref|NM_001100758.2|",3869,0,"Rattus norvegicus myosin binding protein C, slow type (Mybpc1), mRNA","Q00872",2090,0,"Myosin-binding protein C, slow-type",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0006936|muscle contraction;GO:0007155|cell adhesion;","GO:0032982|myosin filament;","GO:0003779|actin binding;GO:0017022|myosin binding;","K12557","MYBPC1; myosin-binding protein C, slow-type"]
["ENSRNOG00000001581",6,0.385982629,20,1.291237193,0.298924652,-1.742146214,0.004711534,2.670871E-3,"down","yes","Hoxd10","protein_coding","chr3:59594516-59597725:+","gi|880859841|ref|XP_005065198.2|",1863,0,"PREDICTED: homeobox protein Hox-D10 [Mesocricetus auratus]","gi|157819366|ref|NM_001107094.1|",1848,0,"Rattus norvegicus homeo box D10 (Hoxd10), mRNA","P28359",648,0,"Homeobox protein Hox-D10",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0001501|skeletal system development;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007338|single fertilization;GO:0007519|skeletal muscle tissue development;GO:0008344|adult locomotory behavior;GO:0009952|anterior/posterior pattern specification;GO:0009954|proximal/distal pattern formation;GO:0010468|regulation of gene expression;GO:0021520|spinal cord motor neuron cell fate specification;GO:0030326|embryonic limb morphogenesis;GO:0035136|forelimb morphogenesis;GO:0035137|hindlimb morphogenesis;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048704|embryonic skeletal system morphogenesis;GO:0048935|peripheral nervous system neuron development;GO:0050905|neuromuscular process;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0036464|cytoplasmic ribonucleoprotein granule;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003700|DNA-binding transcription factor activity;GO:1990837|sequence-specific double-stranded DNA binding;","K09295","HOXD10; homrobox protein Hox-D10"]
["ENSRNOG00000018238",6,0.385982629,20,1.291237193,0.298924652,-1.742146214,0.004711534,2.670871E-3,"down","yes","Nuggc","protein_coding","chr15:39821855-39866122:+","gi|672028655|ref|XP_008767563.1|",4070,0,"PREDICTED: nuclear GTPase SLIP-GC [Rattus norvegicus]","gi|672028654|ref|XM_008769341.1|",2634,0,"PREDICTED: Rattus norvegicus nuclear GTPase, germinal center associated (Nuggc), mRNA","D3YWJ0",1424,0,"Nuclear GTPase SLIP-GC",".",".",".",".","pfam00350","Dynamin_N","Dynamin family.","GO:0006974|cellular response to DNA damage stimulus;GO:0016446|somatic hypermutation of immunoglobulin genes;GO:0033262|regulation of nuclear cell cycle DNA replication;GO:0043066|negative regulation of apoptotic process;GO:0071222|cellular response to lipopolysaccharide;","GO:0005634|nucleus;","GO:0003924|GTPase activity;",".","."]
["ENSRNOG00000062851",6,0.385982629,20,1.291237193,0.298924652,-1.742146214,0.004711534,2.670871E-3,"down","yes","ENSRNOG00000062851","lncRNA","chr17:47090208-47092104:-",".",".",".",".","gi|568899403|ref|XM_006543047.1|",558,0,"PREDICTED: Mus musculus predicted gene, 32699 (Gm32699), mRNA",".",".",".",".",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.",".",".",".",".","."]
["ENSRNOG00000012215",14,0.900626135,33,2.130541369,0.422721731,-1.242219817,0.004761596,0.002698179,"down","yes","Baiap2l2","protein_coding","chr7:110824375-110850702:-","gi|403420586|ref|NP_001258149.1|",2275,0,"brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 [Rattus norvegicus]","gi|403420585|ref|NM_001271220.1|",2079,0,"Rattus norvegicus BAI1-associated protein 2-like 2 (Baiap2l2), mRNA","Q80Y61",868,0,"Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2",".",".",".",".","pfam08397","IMD","IRSp53/MIM homology domain. The N-terminal predicted helical stretch of the insulin receptor tyrosine kinase substrate p53 (IRSp53) is an evolutionary conserved F-actin bundling domain involved in filopodium formation. The domain has been named IMD after the IRSp53 and missing in metastasis (MIM) proteins in which it occurs. Filopodium-inducing IMD activity is regulated by Cdc42 and Rac1 and is SH3-independent.","GO:0007009|plasma membrane organization;GO:0030838|positive regulation of actin filament polymerization;GO:0051017|actin filament bundle assembly;GO:0051764|actin crosslink formation;GO:0061024|membrane organization;GO:2000251|positive regulation of actin cytoskeleton reorganization;","GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0012506|vesicle membrane;GO:0044291|cell-cell contact zone;GO:0071439|clathrin complex;","GO:0005543|phospholipid binding;GO:0042802|identical protein binding;","K23645","BAIAP2L2; BAI1-associated protein 2-like protein 2"]
["ENSRNOG00000011726",2,0.128660876,12,0.774742316,0.166069251,-2.59014312,0.004956029,0.002803627,"down","yes","Grin1","protein_coding","chr3:8103680-8130603:-","gi|396578144|ref|NP_001257531.1|",5204,0,"glutamate receptor ionotropic, NMDA 1 isoform 1b precursor [Rattus norvegicus]","gi|396578143|ref|NM_001270602.1|",4343,0,"Rattus norvegicus glutamate ionotropic receptor NMDA type subunit 1 (Grin1), transcript variant 1, mRNA","P35439",1955,0,"Glutamate receptor ionotropic, NMDA 1",".",".",".",".","pfam00060","Lig_chan","Ligand-gated ion channel. This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.","GO:0001661|conditioned taste aversion;GO:0001964|startle response;GO:0001967|suckling behavior;GO:0001975|response to amphetamine;GO:0006812|cation transport;GO:0006816|calcium ion transport;GO:0006874|cellular calcium ion homeostasis;GO:0007268|chemical synaptic transmission;GO:0007611|learning or memory;GO:0007612|learning;GO:0007613|memory;GO:0007616|long-term memory;GO:0008306|associative learning;GO:0008344|adult locomotory behavior;GO:0008355|olfactory learning;GO:0008542|visual learning;GO:0010524|positive regulation of calcium ion transport into cytosol;GO:0010646|regulation of cell communication;GO:0010942|positive regulation of cell death;GO:0014070|response to organic cyclic compound;GO:0014075|response to amine;GO:0018964|propylene metabolic process;GO:0019233|sensory perception of pain;GO:0019722|calcium-mediated signaling;GO:0021586|pons maturation;GO:0021987|cerebral cortex development;GO:0035176|social behavior;GO:0035235|ionotropic glutamate receptor signaling pathway;GO:0035249|synaptic transmission, glutamatergic;GO:0042391|regulation of membrane potential;GO:0043065|positive regulation of apoptotic process;GO:0043278|response to morphine;GO:0043523|regulation of neuron apoptotic process;GO:0043524|negative regulation of neuron apoptotic process;GO:0043576|regulation of respiratory gaseous exchange;GO:0045471|response to ethanol;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048167|regulation of synaptic plasticity;GO:0048168|regulation of neuronal synaptic plasticity;GO:0048169|regulation of long-term neuronal synaptic plasticity;GO:0048511|rhythmic process;GO:0048814|regulation of dendrite morphogenesis;GO:0050770|regulation of axonogenesis;GO:0050905|neuromuscular process;GO:0051290|protein heterotetramerization;GO:0051592|response to calcium ion;GO:0051963|regulation of synapse assembly;GO:0055074|calcium ion homeostasis;GO:0060079|excitatory postsynaptic potential;GO:0060134|prepulse inhibition;GO:0060179|male mating behavior;GO:0060992|response to fungicide;GO:0065003|protein-containing complex assembly;GO:0071287|cellular response to manganese ion;GO:0097553|calcium ion transmembrane import into cytosol;GO:0099505|regulation of presynaptic membrane potential;GO:1900149|positive regulation of Schwann cell migration;GO:1902952|positive regulation of dendritic spine maintenance;GO:1903428|positive regulation of reactive oxygen species biosynthetic process;GO:1903539|protein localization to postsynaptic membrane;GO:1905429|response to glycine;GO:2000463|positive regulation of excitatory postsynaptic potential;GO:2001056|positive regulation of cysteine-type endopeptidase activity;","GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0008021|synaptic vesicle;GO:0009986|cell surface;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0016323|basolateral plasma membrane;GO:0017146|NMDA selective glutamate receptor complex;GO:0030425|dendrite;GO:0030672|synaptic vesicle membrane;GO:0032590|dendrite membrane;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043083|synaptic cleft;GO:0043195|terminal bouton;GO:0043197|dendritic spine;GO:0044307|dendritic branch;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0060076|excitatory synapse;GO:0097060|synaptic membrane;GO:0098686|hippocampal mossy fiber to CA3 synapse;GO:0098688|parallel fiber to Purkinje cell synapse;GO:0098839|postsynaptic density membrane;GO:0098978|glutamatergic synapse;GO:0099056|integral component of presynaptic membrane;GO:0099061|integral component of postsynaptic density membrane;","GO:0001540|amyloid-beta binding;GO:0004970|ionotropic glutamate receptor activity;GO:0004972|NMDA glutamate receptor activity;GO:0005102|signaling receptor binding;GO:0005261|cation channel activity;GO:0005262|calcium channel activity;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0005516|calmodulin binding;GO:0015276|ligand-gated ion channel activity;GO:0016594|glycine binding;GO:0016595|glutamate binding;GO:0019899|enzyme binding;GO:0019902|phosphatase binding;GO:0022843|voltage-gated cation channel activity;GO:0022849|glutamate-gated calcium ion channel activity;GO:0035254|glutamate receptor binding;GO:0038023|signaling receptor activity;GO:0042165|neurotransmitter binding;GO:0044877|protein-containing complex binding;GO:0099507|ligand-gated ion channel activity involved in regulation of presynaptic membrane potential;GO:1904315|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K05208","GRIN1; glutamate receptor ionotropic, NMDA 1"]
["ENSRNOG00000012478",2,0.128660876,12,0.774742316,0.166069251,-2.59014312,0.004956029,0.002803627,"down","yes","Shox2","protein_coding","chr2:151217552-151227143:-","gi|149048354|gb|EDM00930.1|",1189,{"v":7e-153,"d":"7.00E-153"},"short stature homeobox 2, isoform CRA_a [Rattus norvegicus]","gi|880926758|ref|XM_005077940.2|",1810,0,"PREDICTED: Mesocricetus auratus short stature homeobox 2 (Shox2), transcript variant X1, mRNA","P70390",461,{"v":8e-154,"d":"8.00E-154"},"Short stature homeobox protein 2","ECU03g1170",55.1,2e-07,"COG5576","pfam00046","Homeobox","Homeobox domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001649|osteoblast differentiation;GO:0002027|regulation of heart rate;GO:0002053|positive regulation of mesenchymal cell proliferation;GO:0002062|chondrocyte differentiation;GO:0002063|chondrocyte development;GO:0003163|sinoatrial node development;GO:0003170|heart valve development;GO:0003172|sinoatrial valve development;GO:0003209|cardiac atrium morphogenesis;GO:0003213|cardiac right atrium morphogenesis;GO:0006357|regulation of transcription by RNA polymerase II;GO:0030326|embryonic limb morphogenesis;GO:0032330|regulation of chondrocyte differentiation;GO:0035115|embryonic forelimb morphogenesis;GO:0045880|positive regulation of smoothened signaling pathway;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048557|embryonic digestive tract morphogenesis;GO:0048598|embryonic morphogenesis;GO:0048743|positive regulation of skeletal muscle fiber development;GO:0050772|positive regulation of axonogenesis;GO:0060272|embryonic skeletal joint morphogenesis;GO:0060351|cartilage development involved in endochondral bone morphogenesis;GO:0060415|muscle tissue morphogenesis;GO:0060920|cardiac pacemaker cell differentiation;GO:0060931|sinoatrial node cell development;GO:2000172|regulation of branching morphogenesis of a nerve;","GO:0005634|nucleus;","GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09331","SHOX; short stature homeobox protein"]
["ENSRNOG00000024762",2,0.128660876,12,0.774742316,0.166069251,-2.59014312,0.004956029,0.002803627,"down","yes","ENSRNOG00000024762","protein_coding","chrX:130377227-130423771:-","gi|564323421|ref|XP_006227622.1|",3886,0,"PREDICTED: FERM domain-containing protein 7 isoform X1 [Rattus norvegicus]","gi|672032808|ref|XM_006227560.2|",2790,0,"PREDICTED: Rattus norvegicus FERM domain containing 7 (Frmd7), mRNA","A2AD83",1340,0,"FERM domain-containing protein 7",".",".",".",".","pfam09380","FERM_C","FERM C-terminal PH-like domain.","GO:0010592|positive regulation of lamellipodium assembly;GO:0010975|regulation of neuron projection development;GO:0032091|negative regulation of protein binding;GO:0050790|regulation of catalytic activity;GO:0051057|positive regulation of small GTPase mediated signal transduction;GO:0051497|negative regulation of stress fiber assembly;","GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0030426|growth cone;GO:0043005|neuron projection;GO:0043025|neuronal cell body;","GO:0005085|guanyl-nucleotide exchange factor activity;","K23971","FRMD7; FERM domain-containing protein 7"]
["ENSRNOG00000024479",5,0.321652191,18,1.162113474,0.276782086,-1.853177526,5.148077E-3,0.002903927,"down","yes","ENSRNOG00000024479","protein_coding","chrX:37151592-37153529:-","gi|34880604|ref|XP_228962.2|",2808,0,"PREDICTED: kelch-like protein 34 [Rattus norvegicus]","gi|672032269|ref|XM_001055437.5|",1938,0,"PREDICTED: Rattus norvegicus kelch-like family member 34 (Klhl34), mRNA","Q8N239",876,0,"Kelch-like protein 34",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.",".",".",".","K10469","KLHL34; kelch-like protein 34"]
["ENSRNOG00000068999",5,0.321652191,18,1.162113474,0.276782086,-1.853177526,5.148077E-3,0.002903927,"down","yes","ENSRNOG00000068999","lncRNA","chr9:61736763-61743926:-","gi|149060708|gb|EDM11422.1|",139,3e-07,"rCG52991, isoform CRA_d [Rattus norvegicus]","gi|672065424|ref|XM_008767175.1|",2209,0,"PREDICTED: Rattus norvegicus neurobeachin-like 1 (Nbeal1), transcript variant X4, mRNA",".",".",".",".",".",".",".",".","pfam11667","DUF3267","Protein of unknown function (DUF3267). This family of proteins has no known function.",".",".",".",".","."]
["ENSRNOG00000006998",21,1.350939202,43,2.776159965,0.486621527,-1.039127951,0.005239711,0.002952991,"down","yes","Fhl4","protein_coding","chr7:18598103-18635184:+","gi|564358781|ref|XP_006241241.1|",1465,0,"PREDICTED: four and a half LIM domains 4 isoform X1 [Rattus norvegicus]","gi|354791984|gb|JN956485.1|",2029,0,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Fhl4:tm1e(EUCOMM)Hmgu; transgenic","Q9WUH4",421,{"v":8e-134,"d":"8.00E-134"},"Four and a half LIM domains protein 1",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.","GO:0007517|muscle organ development;",".","GO:0044325|ion channel binding;GO:0046872|metal ion binding;",".","."]
["ENSRNOG00000001528",3,0.192991315,14,0.903866035,0.213517609,-2.227573041,0.005445499,0.003057805,"down","yes","Gap43","protein_coding","chr11:58376371-58470045:+","gi|8393415|ref|NP_058891.1|",496,{"v":1e-55,"d":"1.00E-55"},"neuromodulin [Rattus norvegicus]","gi|166091453|ref|NM_017195.3|",1481,0,"Rattus norvegicus growth associated protein 43 (Gap43), mRNA","P07936",195,{"v":3E-57,"d":"3.00E-57"},"Neuromodulin",".",".",".",".","pfam10580","Neuromodulin_N","Gap junction protein N-terminal region.","GO:0007399|nervous system development;GO:0007411|axon guidance;GO:0010001|glial cell differentiation;GO:0016198|axon choice point recognition;GO:0031103|axon regeneration;GO:0040008|regulation of growth;GO:0042246|tissue regeneration;GO:0045165|cell fate commitment;GO:0051489|regulation of filopodium assembly;GO:0099150|regulation of postsynaptic specialization assembly;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0030424|axon;GO:0030425|dendrite;GO:0030426|growth cone;GO:0031527|filopodium membrane;GO:0032584|growth cone membrane;GO:0043204|perikaryon;GO:0071944|cell periphery;GO:0098793|presynapse;GO:0098982|GABA-ergic synapse;","GO:0001786|phosphatidylserine binding;GO:0005515|protein binding;GO:0005516|calmodulin binding;GO:0035727|lysophosphatidic acid binding;GO:1901981|phosphatidylinositol phosphate binding;","K20041","GAP43; neuromodulin"]
["ENSRNOG00000017381",3,0.192991315,14,0.903866035,0.213517609,-2.227573041,0.005445499,0.003057805,"down","yes","Itih4","protein_coding","chr16:6080539-6095708:+","gi|126722991|ref|NP_062242.2|",4701,0,"inter-alpha-trypsin inhibitor heavy chain H4 precursor [Rattus norvegicus]","gi|126722990|ref|NM_019369.2|",2962,0,"Rattus norvegicus inter-alpha-trypsin inhibitor heavy chain family, member 4 (Itih4), mRNA","A6X935",1493,0,"Inter alpha-trypsin inhibitor, heavy chain 4","alr4412",110,{"v":1e-23,"d":"1.00E-23"},"COG2304","pfam08487","VIT","Vault protein inter-alpha-trypsin domain. Inter-alpha-trypsin inhibitors (ITIs) consist of one light chain and a variable set of heavy chains. ITIs play a role in extracellular matrix (ECM) stabilisation and tumor metastasis as well as in plasma protease inhibition. The vault protein inter-alpha-trypsin (VIT) domain described here is found to the N-terminus of a von Willebrand factor type A domain (pfam00092) in ITI heavy chains (ITIHs) and their precursors.","GO:0006953|acute-phase response;GO:0008150|biological_process;GO:0010951|negative regulation of endopeptidase activity;GO:0030212|hyaluronan metabolic process;GO:0034097|response to cytokine;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005886|plasma membrane;","GO:0003674|molecular_function;GO:0004867|serine-type endopeptidase inhibitor activity;","K24514","ITIH4; inter-alpha-trypsin inhibitor heavy chain H4"]
["ENSRNOG00000054809",3,0.192991315,14,0.903866035,0.213517609,-2.227573041,0.005445499,0.003057805,"down","yes","AABR07026032.1","protein_coding","chr16:56422138-56471065:-","gi|568954435|ref|XP_006509298.1|",9958,0,"PREDICTED: prolow-density lipoprotein receptor-related protein 1-like isoform X6 [Mus musculus]","gi|755525283|ref|XM_006509235.2|",4837,0,"PREDICTED: Mus musculus predicted gene, 19410 (Gm19410), transcript variant X6, mRNA","C0HL13",622,{"v":1E-180,"d":"1.00E-180"},"Low-density lipoprotein receptor-related protein 2",".",".",".",".","pfam00057","Ldl_recept_a","Low-density lipoprotein receptor domain class A.",".",".",".",".","."]
["ENSRNOG00000010600",11,0.70763482,28,1.80773207,0.39144895,-1.353103923,5.464333E-3,3.068079E-3,"down","yes","Cysrt1","protein_coding","chr3:8053482-8059721:-","gi|157822119|ref|NP_001102664.1|",448,{"v":2e-47,"d":"2.00E-47"},"UPF0574 protein C9orf169 homolog [Rattus norvegicus]","gi|354797676|gb|JN962177.1|",1541,0,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Ndor1:tm1a(EUCOMM)Hmgu; transgenic",".",".",".",".",".",".",".",".","pfam10631","DUF2477","Protein of unknown function (DUF2477). This is a family of proteins with no known function. The family is rich in proline residues.",".",".","GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000004560",0,0.032165219,8,0.516494877,0.062275969,-4.005180619,0.00550014,0.003079102,"down","yes","Cacna1b","protein_coding","chr3:7380922-7546091:-","gi|564339493|ref|XP_006233639.1|",11078,0,"PREDICTED: voltage-dependent N-type calcium channel subunit alpha-1B isoform X9 [Rattus norvegicus]","gi|672044626|ref|XM_006233577.2|",9726,0,"PREDICTED: Rattus norvegicus calcium channel, voltage-dependent, N type, alpha 1B subunit (Cacna1b), transcript variant X9, mRNA","Q02294",4267,0,"Voltage-dependent N-type calcium channel subunit alpha-1B",".",".",".",".","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0001956|positive regulation of neurotransmitter secretion;GO:0006816|calcium ion transport;GO:0007268|chemical synaptic transmission;GO:0007269|neurotransmitter secretion;GO:0007626|locomotory behavior;GO:0008016|regulation of heart contraction;GO:0008217|regulation of blood pressure;GO:0014070|response to organic cyclic compound;GO:0019233|sensory perception of pain;GO:0033574|response to testosterone;GO:0034765|regulation of ion transmembrane transport;GO:0045471|response to ethanol;GO:0048265|response to pain;GO:0050804|modulation of chemical synaptic transmission;GO:0051924|regulation of calcium ion transport;GO:0070509|calcium ion import;GO:0070588|calcium ion transmembrane transport;GO:0099703|induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration;GO:1904645|response to amyloid-beta;","GO:0005886|plasma membrane;GO:0005891|voltage-gated calcium channel complex;GO:0016020|membrane;GO:0016323|basolateral plasma membrane;GO:0030425|dendrite;GO:0032991|protein-containing complex;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043198|dendritic shaft;GO:0043679|axon terminus;GO:0044306|neuron projection terminus;GO:0060171|stereocilium membrane;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098978|glutamatergic synapse;","GO:0005245|voltage-gated calcium channel activity;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0008022|protein C-terminus binding;GO:0008331|high voltage-gated calcium channel activity;GO:0051721|protein phosphatase 2A binding;GO:0099635|voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels;","K04849","CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B"]
["ENSRNOG00000006174",0,0.032165219,8,0.516494877,0.062275969,-4.005180619,0.00550014,0.003079102,"down","yes","Grid2","protein_coding","chr4:92415230-93889355:+","gi|38372261|sp|Q63226.2|GRID2_RAT",5285,0,"RecName: Full=Glutamate receptor ionotropic, delta-2; Short=GluD2; Short=GluR delta-2 subunit; Flags: Precursor","gi|13259381|ref|NM_024379.1|",4501,0,"Rattus norvegicus glutamate ionotropic receptor delta type subunit 2 (Grid2), mRNA","Q63226",2038,0,"Glutamate receptor ionotropic, delta-2",".",".",".",".","pfam00060","Lig_chan","Ligand-gated ion channel. This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.","GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0008150|biological_process;GO:0010975|regulation of neuron projection development;GO:0021707|cerebellar granule cell differentiation;GO:0034220|ion transmembrane transport;GO:0034613|cellular protein localization;GO:0035235|ionotropic glutamate receptor signaling pathway;GO:0035249|synaptic transmission, glutamatergic;GO:0043523|regulation of neuron apoptotic process;GO:0050804|modulation of chemical synaptic transmission;GO:0051965|positive regulation of synapse assembly;GO:0060079|excitatory postsynaptic potential;GO:0060134|prepulse inhibition;GO:0099151|regulation of postsynaptic density assembly;GO:1900454|positive regulation of long-term synaptic depression;GO:1904861|excitatory synapse assembly;GO:1905606|regulation of presynapse assembly;","GO:0005886|plasma membrane;GO:0008328|ionotropic glutamate receptor complex;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0036477|somatodendritic compartment;GO:0043197|dendritic spine;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0098688|parallel fiber to Purkinje cell synapse;GO:0098978|glutamatergic synapse;GO:0099061|integral component of postsynaptic density membrane;","GO:0003674|molecular_function;GO:0004970|ionotropic glutamate receptor activity;GO:0008066|glutamate receptor activity;GO:0015276|ligand-gated ion channel activity;GO:0030165|PDZ domain binding;GO:0038023|signaling receptor activity;GO:0042802|identical protein binding;GO:0097110|scaffold protein binding;GO:1904315|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K05207","GRID2; glutamate receptor delta-2 subunit"]
["ENSRNOG00000008700",0,0.032165219,8,0.516494877,0.062275969,-4.005180619,0.00550014,0.003079102,"down","yes","Cryba1","protein_coding","chr10:62608383-62614726:-","gi|402766651|ref|NP_037188.1|",1121,{"v":5e-153,"d":"5.00E-153"},"beta-crystallin A3 [Rattus norvegicus]","gi|402766650|ref|NM_013056.1|",772,0,"Rattus norvegicus crystallin, beta A1 (Cryba1), mRNA","P14881",436,{"v":2e-154,"d":"2.00E-154"},"Beta-crystallin A3",".",".",".",".","pfam00030","Crystall","Beta/Gamma crystallin. The alignment comprises two Greek key motifs since the similarity between them is very low.","GO:0001818|negative regulation of cytokine production;GO:0002088|lens development in camera-type eye;GO:0006909|phagocytosis;GO:0007601|visual perception;GO:0010506|regulation of autophagy;GO:0014067|negative regulation of phosphatidylinositol 3-kinase signaling;GO:0032007|negative regulation of TOR signaling;GO:0043010|camera-type eye development;GO:0051898|negative regulation of protein kinase B signaling;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:2000210|positive regulation of anoikis;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005764|lysosome;","GO:0003674|molecular_function;GO:0005212|structural constituent of eye lens;GO:0042802|identical protein binding;","K23482","CRYB; beta-crystallin"]
["ENSRNOG00000015788",0,0.032165219,8,0.516494877,0.062275969,-4.005180619,0.00550014,0.003079102,"down","yes","Adora3","protein_coding","chr2:193388713-193392357:+","gi|713693919|ref|NP_001289684.1|",1762,0,"adenosine receptor A3 isoform a [Rattus norvegicus]","gi|713693918|ref|NM_001302755.1|",1815,0,"Rattus norvegicus adenosine A3 receptor (Adora3), transcript variant A3i, mRNA","P28647",618,0,"Adenosine receptor A3",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001973|adenosine receptor signaling pathway;GO:0008285|negative regulation of cell proliferation;GO:0030336|negative regulation of cell migration;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0098685|Schaffer collateral - CA1 synapse;","GO:0001609|G protein-coupled adenosine receptor activity;GO:0004888|transmembrane signaling receptor activity;","K04268","ADORA3; adenosine receptor A3"]
["ENSRNOG00000022707",0,0.032165219,8,0.516494877,0.062275969,-4.005180619,0.00550014,0.003079102,"down","yes","Pmp2","protein_coding","chr2:91611334-91615252:+","gi|157816903|ref|NP_001102984.1|",690,{"v":4e-86,"d":"4.00E-86"},"myelin P2 protein [Rattus norvegicus]","gi|157816902|ref|NM_001109514.1|",1341,0,"Rattus norvegicus peripheral myelin protein 2 (Pmp2), mRNA","P24526",262,{"v":1E-84,"d":"1.00E-84"},"Myelin P2 protein",".",".",".",".","pfam00061","Lipocalin","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.","GO:0061024|membrane organization;","GO:0005737|cytoplasm;GO:0043209|myelin sheath;","GO:0005504|fatty acid binding;GO:0015485|cholesterol binding;","K24977","PMP2; myelin P2 protein"]
["ENSRNOG00000026759",0,0.032165219,8,0.516494877,0.062275969,-4.005180619,0.00550014,0.003079102,"down","yes","Ccr8","protein_coding","chr8:119826568-119827629:+","gi|672023455|ref|XP_008756107.1|",1718,0,"PREDICTED: C-C chemokine receptor type 8 [Rattus norvegicus]","gi|672023454|ref|XM_008757885.1|",1062,0,"PREDICTED: Rattus norvegicus chemokine (C-C motif) receptor 8 (Ccr8), mRNA","P56484",616,0,"C-C chemokine receptor type 8",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0006935|chemotaxis;GO:0006955|immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0019722|calcium-mediated signaling;GO:0060326|cell chemotaxis;GO:0070098|chemokine-mediated signaling pathway;","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0016493|C-C chemokine receptor activity;GO:0019957|C-C chemokine binding;","K04183","CCR8, CDw198; C-C chemokine receptor type 8"]
["ENSRNOG00000030812",0,0.032165219,8,0.516494877,0.062275969,-4.005180619,0.00550014,0.003079102,"down","yes","AABR07065781.1","protein_coding","chr6:134488094-134488587:-","gi|148705256|gb|EDL37203.1|",489,{"v":1e-60,"d":"1.00E-60"},"mCG140410, partial [Mus musculus]","gi|62201946|gb|BC092582.1|",376,0,"Rattus norvegicus similar to single chain Fv antibody fragment scFv 7-10A, mRNA (cDNA clone IMAGE:7373926)","P18532",178,{"v":2e-56,"d":"2.00E-56"},"Ig heavy chain V region 1B43",".",".",".",".","pfam00047","ig","Immunoglobulin domain. Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions. The Pfam alignments do not include the first and last strand of the immunoglobulin-like domain.",".",".",".",".","."]
["ENSRNOG00000035641",0,0.032165219,8,0.516494877,0.062275969,-4.005180619,0.00550014,0.003079102,"down","yes","Mir138-1","miRNA","chr8:122300966-122301064:+","gi|594096036|ref|XP_006071288.1|",135,2E-8,"PREDICTED: uncharacterized protein LOC102404169 [Bubalus bubalis]","gi|296923678|ref|NR_031885.1|",99,{"v":2e-43,"d":"2.00E-43"},"Rattus norvegicus microRNA 138-1 (Mir138-1), microRNA",".",".",".",".",".",".",".",".","pfam05147","LANC_like","Lanthionine synthetase C-like protein. Lanthionines are thioether bridges that are putatively generated by dehydration of Ser and Thr residues followed by addition of cysteine residues within the peptide. This family contains the lanthionine synthetase C-like proteins 1 and 2 which are related to the bacterial lanthionine synthetase components C (LanC). LANCL1 (P40 seven-transmembrane-domain protein) and LANCL2 (testes-specific adriamycin sensitivity protein) are thought to be peptide-modifying enzyme components in eukaryotic cells. Both proteins are produced in large quantities in the brain and testes and may have role in the immune surveillance of these organs. Lanthionines are found in lantibiotics, which are peptide-derived, post-translationally modified antimicrobials produced by several bacterial strains. This region contains seven internal repeats.","GO:0042552|myelination;GO:0046660|female sex differentiation;GO:0060291|long-term synaptic potentiation;GO:0071363|cellular response to growth factor stimulus;",".",".",".","."]
["ENSRNOG00000052942",0,0.032165219,8,0.516494877,0.062275969,-4.005180619,0.00550014,0.003079102,"down","yes","AABR07062513.1","lncRNA","chr4:179419951-179434661:-",".",".",".",".","gi|49170279|gb|AC129573.16|",993,0,"Mus musculus chromosome 6, clone RP23-457B5, complete sequence",".",".",".",".",".",".",".",".","pfam10344","Fmp27","Mitochondrial protein from FMP27. This family contains mitochondrial FMP27 proteins which in yeasts together with SEN1 are long genes that exist in a looped conformation, effectively bringing together their promoter and terminator regions. Pol-II is located at both ends of FMP27 when this gene is transcribed from a GAL1 promoter under induced and non-induced conditions. The exact function of the Fmp27 protein is not certain.",".",".",".",".","."]
["ENSRNOG00000053255",0,0.032165219,8,0.516494877,0.062275969,-4.005180619,0.00550014,0.003079102,"down","yes","U6","snRNA","chr20:13044794-13044892:+",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","pfam14744","WASH-7_mid","WASH complex subunit 7. This family is the central, conserved region of proteins that form subunit 7 of the WASH complex. In species such as Drosophila this protein is the only component of the 'complex'. This complex is a nucleation promoting factor necessary for the activation of Arp2/3 that nucleates and organizes actin filaments by associating with a pre-existing filament to induce the assembly of a branching filament. WASH thus effectively nucleates actin on endosomes.",".",".",".",".","."]
["ENSRNOG00000064495",0,0.032165219,8,0.516494877,0.062275969,-4.005180619,0.00550014,0.003079102,"down","yes","ENSRNOG00000064495","lncRNA","chr19:52912680-52915635:+","gi|149036607|gb|EDL91225.1|",229,{"v":2E-19,"d":"2.00E-19"},"rCG56442 [Rattus norvegicus]","gi|111038150|gb|AC132998.5|",164,{"v":4E-78,"d":"4.00E-78"},"Rattus norvegicus BAC CH230-6L10 () complete sequence","P46935",54.3,3e-06,"E3 ubiquitin-protein ligase NEDD4",".",".",".",".",".",".",".",".",".",".",".","."]
["ENSRNOG00000068312",0,0.032165219,8,0.516494877,0.062275969,-4.005180619,0.00550014,0.003079102,"down","yes","ENSRNOG00000068312","protein_coding","chr17:85840866-85848563:-","gi|672030377|ref|XP_008772276.1|",2240,0,"PREDICTED: sperm motility kinase X-like [Rattus norvegicus]","gi|672082628|ref|XR_596890.1|",2333,0,"PREDICTED: Rattus norvegicus similar to MAP/microtubule affinity-regulating kinase 4 (MAP/microtubule affinity-regulating kinase like 1) (RGD1561231), transcript variant X6, misc_RNA","Q8C0X8",281,{"v":3e-80,"d":"3.00E-80"},"Sperm motility kinase X",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.",".",".",".",".","."]
["ENSRNOG00000069708",0,0.032165219,8,0.516494877,0.062275969,-4.005180619,0.00550014,0.003079102,"down","yes","ENSRNOG00000069708","lncRNA","chr9:11569804-11573945:-","gi|564367080|ref|XP_006244480.1|",312,{"v":1E-27,"d":"1.00E-27"},"PREDICTED: molybdenum cofactor biosynthesis protein 1 isoform X4 [Rattus norvegicus]","gi|672064242|ref|XM_006244415.2|",273,{"v":1e-138,"d":"1.00E-138"},"PREDICTED: Rattus norvegicus molybdenum cofactor synthesis 1 (Mocs1), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam05604","DUF776","Protein of unknown function (DUF776). This family consists of several highly related mouse and human proteins of unknown function.",".",".",".",".","."]
["ENSRNOG00000011702",13,0.836295696,31,2.001417649,0.417851665,-1.258937212,0.005698249,3.180034E-3,"down","yes","ENSRNOG00000011702","protein_coding","chrX:14908494-14923838:-","gi|157818139|ref|NP_001101720.1|",1749,0,"forkhead box protein P3 [Rattus norvegicus]","gi|157818138|ref|NM_001108250.1|",3185,0,"Rattus norvegicus forkhead box P3 (Foxp3), mRNA","Q99JB6",645,0,"Forkhead box protein P3","YCR065w",83.2,{"v":2e-15,"d":"2.00E-15"},"COG5025","pfam00250","Fork_head","Fork head domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001782|B cell homeostasis;GO:0001818|negative regulation of cytokine production;GO:0002262|myeloid cell homeostasis;GO:0002361|CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0002456|T cell mediated immunity;GO:0002507|tolerance induction;GO:0002513|tolerance induction to self antigen;GO:0002637|regulation of immunoglobulin production;GO:0002666|positive regulation of T cell tolerance induction;GO:0002667|regulation of T cell anergy;GO:0002669|positive regulation of T cell anergy;GO:0002677|negative regulation of chronic inflammatory response;GO:0002725|negative regulation of T cell cytokine production;GO:0002851|positive regulation of peripheral T cell tolerance induction;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008285|negative regulation of cell proliferation;GO:0009314|response to radiation;GO:0009615|response to virus;GO:0010467|gene expression;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0014045|establishment of endothelial blood-brain barrier;GO:0031064|negative regulation of histone deacetylation;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0032496|response to lipopolysaccharide;GO:0032689|negative regulation of interferon-gamma production;GO:0032693|negative regulation of interleukin-10 production;GO:0032700|negative regulation of interleukin-17 production;GO:0032703|negative regulation of interleukin-2 production;GO:0032713|negative regulation of interleukin-4 production;GO:0032714|negative regulation of interleukin-5 production;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032753|positive regulation of interleukin-4 production;GO:0032792|negative regulation of CREB transcription factor activity;GO:0032831|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0032914|positive regulation of transforming growth factor beta1 production;GO:0033092|positive regulation of immature T cell proliferation in thymus;GO:0035066|positive regulation of histone acetylation;GO:0035067|negative regulation of histone acetylation;GO:0042110|T cell activation;GO:0042130|negative regulation of T cell proliferation;GO:0043433|negative regulation of DNA-binding transcription factor activity;GO:0045591|positive regulation of regulatory T cell differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048294|negative regulation of isotype switching to IgE isotypes;GO:0048302|regulation of isotype switching to IgG isotypes;GO:0050672|negative regulation of lymphocyte proliferation;GO:0050687|negative regulation of defense response to virus;GO:0050728|negative regulation of inflammatory response;GO:0050777|negative regulation of immune response;GO:0050852|T cell receptor signaling pathway;GO:1901355|response to rapamycin;GO:2000320|negative regulation of T-helper 17 cell differentiation;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0003714|transcription corepressor activity;GO:0035035|histone acetyltransferase binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0042826|histone deacetylase binding;GO:0043565|sequence-specific DNA binding;GO:0046872|metal ion binding;GO:0051525|NFAT protein binding;GO:1990837|sequence-specific double-stranded DNA binding;","K10163","FOXP3, IPEX; forkhead box P3"]
["ENSRNOG00000011114",10,0.643304382,26,1.678608351,0.383236734,-1.383692243,0.00646353,3.58435E-3,"down","yes","Tbpl1","protein_coding","chr1:22778492-22803302:+","gi|4759234|ref|NP_004856.1|",787,{"v":8e-101,"d":"8.00E-101"},"TATA box-binding protein-like protein 1 [Homo sapiens]","gi|187761294|ref|NM_001127201.1|",891,0,"Rattus norvegicus TATA-box binding protein like 1 (Tbpl1), mRNA","P62340",307,{"v":3E-102,"d":"3.00E-102"},"TATA box-binding protein-like protein 1","SPAC29E6.08",120,{"v":1e-30,"d":"1.00E-30"},"COG2101","pfam00352","TBP","Transcription factor TFIID (or TATA-binding protein, TBP).","GO:0001675|acrosome assembly;GO:0006235|dTTP biosynthetic process;GO:0006352|DNA-templated transcription, initiation;GO:0006366|transcription by RNA polymerase II;GO:0007283|spermatogenesis;GO:0007289|spermatid nucleus differentiation;","GO:0005634|nucleus;GO:0005672|transcription factor TFIIA complex;GO:0005737|cytoplasm;","GO:0000979|RNA polymerase II core promoter sequence-specific DNA binding;GO:0016251|RNA polymerase II general transcription initiation factor activity;GO:0140223|general transcription initiation factor activity;","K03120","TBP, tbp; transcription initiation factor TFIID TATA-box-binding protein"]
["ENSRNOG00000012430",10,0.643304382,26,1.678608351,0.383236734,-1.383692243,0.00646353,3.58435E-3,"down","yes","Cxcr5","protein_coding","chr8:44843413-44857893:-","gi|564363302|ref|XP_006242963.1|",1860,0,"PREDICTED: C-X-C chemokine receptor type 5 isoform X1 [Rattus norvegicus]","gi|672061603|ref|XM_006242901.2|",1342,0,"PREDICTED: Rattus norvegicus chemokine (C-X-C motif) receptor 5 (Cxcr5), transcript variant X1, mRNA","P34997",710,0,"C-X-C chemokine receptor type 5",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0006955|immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0019722|calcium-mediated signaling;GO:0030595|leukocyte chemotaxis;GO:0032467|positive regulation of cytokinesis;GO:0042113|B cell activation;GO:0048535|lymph node development;GO:0060326|cell chemotaxis;GO:0070098|chemokine-mediated signaling pathway;","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0016493|C-C chemokine receptor activity;GO:0016494|C-X-C chemokine receptor activity;GO:0019957|C-C chemokine binding;","K04190","CXCR5, BLR1, CD185; C-X-C chemokine receptor type 5"]
["ENSRNOG00000069178",10,0.643304382,26,1.678608351,0.383236734,-1.383692243,0.00646353,3.58435E-3,"down","yes","ENSRNOG00000069178","protein_coding","chr1:62622774-62624414:-","gi|1791243|gb|AAB41224.1|",503,{"v":7e-100,"d":"7.00E-100"},"ORF2 [Rattus norvegicus]","gi|66792958|gb|AC159909.8|",526,0,"Mus musculus 10 BAC RP23-312M21 (Roswell Park Cancer Institute (C57BL/6J Female) Mouse BAC Library) complete sequence","P11369",186,{"v":2e-93,"d":"2.00E-93"},"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam08333","DUF1725","Protein of unknown function (DUF1725). This family include many eukaryotic and one bacterial sequence. Many of its members are annotated as being putative L1 retrotransposons or LINE-1 reverse transcriptase homologs. The region in question is found repeated in some family members.",".",".",".",".","."]
["ENSRNOG00000064366",18,1.157947887,38,2.453350667,0.471986293,-1.083183131,6.626669E-3,0.003668407,"down","yes","ENSRNOG00000064366","lncRNA","chr12:38567761-38569918:-","gi|148677466|gb|EDL09413.1|",226,{"v":2E-19,"d":"2.00E-19"},"mCG147326 [Mus musculus]","gi|226192808|gb|AC096406.7|",191,{"v":3e-93,"d":"3.00E-93"},"Rattus norvegicus CH230-62C22 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam15024","Glyco_transf_18","Glycosyltransferase family 18. Enzymes belonging to glycosyltransferase family 18 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase) contribute to the creation of branches in complex-type N-glycans. This domain is responsible for the catalytic activity of the enzyme.",".",".",".",".","."]
["ENSRNOG00000025365",7,0.450313067,21,1.355799053,0.332138503,-1.59014312,0.006651795,0.00367982,"down","yes","Ido2","protein_coding","chr16:67459190-67496324:+","gi|392333687|ref|XP_003752968.1|",2148,0,"PREDICTED: indoleamine 2,3-dioxygenase 2 isoform X1 [Rattus norvegicus]","gi|672029515|ref|XM_003752920.3|",1677,0,"PREDICTED: Rattus norvegicus indoleamine 2,3-dioxygenase 2 (Ido2), transcript variant X1, mRNA","F1LV46",832,0,"Indoleamine 2,3-dioxygenase 2",".",".",".",".","pfam01231","IDO","Indoleamine 2,3-dioxygenase.","GO:0002376|immune system process;GO:0019441|tryptophan catabolic process to kynurenine;GO:0034354|'de novo' NAD biosynthetic process from tryptophan;","GO:0005737|cytoplasm;","GO:0004833|tryptophan 2,3-dioxygenase activity;GO:0020037|heme binding;GO:0033754|indoleamine 2,3-dioxygenase activity;GO:0046872|metal ion binding;","K00463","IDO, INDO; indoleamine 2,3-dioxygenase [EC:1.13.11.52]"]
["ENSRNOG00000071122",7,0.450313067,21,1.355799053,0.332138503,-1.59014312,0.006651795,0.00367982,"down","yes","ENSRNOG00000071122","lncRNA","chr13:102806501-102851955:+","gi|672027525|ref|XP_008762119.1|",585,{"v":2e-65,"d":"2.00E-65"},"PREDICTED: uncharacterized protein LOC102555043 [Rattus norvegicus]","gi|254763240|gb|AC125873.4|",2518,0,"Rattus norvegicus BAC CH230-376K5 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam05210","Sprouty","Sprouty protein (Spry). This family consists of eukaryotic Sprouty protein homologues. Sprouty proteins have been revealed as inhibitors of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases. The sprouty gene has found to be expressed in the the brain, cochlea, nasal organs, teeth, salivary gland, lungs, digestive tract, kidneys and limb buds in mice.",".",".",".",".","."]
["ENSRNOG00000039463",12,0.771965258,29,1.87229393,0.412309865,-1.278199114,0.006812894,0.003761654,"down","yes","Pcdhga1","lncRNA","chr18:29487482-29492857:-","gi|80751173|ref|NP_001032217.1|",3938,0,"protocadherin gamma-A1 precursor [Rattus norvegicus]","gi|13899409|gb|AC020971.3|AC020971",2420,0,"Mus musculus chromosome 18 clone RP23-56B11, complete sequence","Q9Y5H4",1280,0,"Protocadherin gamma-A1",".",".",".",".","pfam08266","Cadherin_2","Cadherin-like. This cadherin domain is usually the most N-terminal copy of the domain.",".",".",".",".","."]
["ENSRNOG00000020446",16,1.029287011,35,2.259665088,0.455504232,-1.134463636,0.006832814,0.003770465,"down","yes","AABR07005838.1","protein_coding","chr1:184215516-184300008:+","gi|57528169|ref|NP_001009624.1|",635,{"v":1e-76,"d":"1.00E-76"},"spindle and kinetochore-associated protein 2 [Rattus norvegicus]","gi|57528168|ref|NM_001009624.1|",453,0,"Rattus norvegicus spindle and kinetochore associated complex subunit 2 (Ska2), mRNA","Q5I0J4",249,{"v":3e-78,"d":"3.00E-78"},"Spindle and kinetochore-associated protein 2",".",".",".",".","pfam13301","DUF4079","Protein of unknown function (DUF4079). This is an uncharacterized family of proteins.",".",".",".",".","."]
["ENSRNOG00000004869",1,0.064330438,9,0.581056737,0.110712834,-3.175105621,0.007029575,3.865224E-3,"down","yes","ENSRNOG00000004869","protein_coding","chrX:78451593-79017592:+","gi|755566064|ref|XP_011246012.1|",2368,0,"PREDICTED: dachshund homolog 2 isoform X3 [Mus musculus]","gi|755566074|ref|XM_011247715.1|",1761,0,"PREDICTED: Mus musculus dachshund 2 (Drosophila) (Dach2), transcript variant X7, mRNA","Q925Q8",811,0,"Dachshund homolog 2",".",".",".",".","pfam02437","Ski_Sno","SKI/SNO/DAC family. This family contains a presumed domain that is about 100 amino acids long. All members of this family contain a conserved CLPQ motif. The c-ski proto-oncogene has been shown to influence proliferation, morphological transformation and myogenic differentiation. Sno, a Ski proto-oncogene homologue, is expressed in two isoforms and plays a role in the response to proliferation stimuli. Dachshund also contains this domain. It is involved in various aspects of development.","GO:0046545|development of primary female sexual characteristics;",".",".",".","."]
["ENSRNOG00000010349",1,0.064330438,9,0.581056737,0.110712834,-3.175105621,0.007029575,3.865224E-3,"down","yes","Ghrl","protein_coding","chr4:146865712-146869621:-","gi|755517129|ref|XP_011239724.1|",498,{"v":2e-59,"d":"2.00E-59"},"PREDICTED: appetite-regulating hormone isoform X2 [Mus musculus]","gi|291463294|ref|NM_021669.2|",500,0,"Rattus norvegicus ghrelin/obestatin prepropeptide (Ghrl), mRNA","Q9QYH7",186,{"v":6e-59,"d":"6.00E-59"},"Appetite-regulating hormone",".",".",".",".","pfam04643","Motilin_assoc","Motilin/ghrelin-associated peptide. This family represents a peptide sequence that lies C-terminal to motilin/ghrelin on the respective precursor peptide. Its function is unknown.","GO:0001696|gastric acid secretion;GO:0001937|negative regulation of endothelial cell proliferation;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0008154|actin polymerization or depolymerization;GO:0008343|adult feeding behavior;GO:0009725|response to hormone;GO:0016358|dendrite development;GO:0031667|response to nutrient levels;GO:0032024|positive regulation of insulin secretion;GO:0032095|regulation of response to food;GO:0032097|positive regulation of response to food;GO:0032100|positive regulation of appetite;GO:0032691|negative regulation of interleukin-1 beta production;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0035483|gastric emptying;GO:0035774|positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0040010|positive regulation of growth rate;GO:0040013|negative regulation of locomotion;GO:0042127|regulation of cell proliferation;GO:0042322|negative regulation of circadian sleep/wake cycle, REM sleep;GO:0043066|negative regulation of apoptotic process;GO:0043410|positive regulation of MAPK cascade;GO:0043627|response to estrogen;GO:0045927|positive regulation of growth;GO:0046010|positive regulation of circadian sleep/wake cycle, non-REM sleep;GO:0046676|negative regulation of insulin secretion;GO:0046697|decidualization;GO:0050728|negative regulation of inflammatory response;GO:0051461|positive regulation of corticotropin secretion;GO:0051464|positive regulation of cortisol secretion;GO:0051602|response to electrical stimulus;GO:0051965|positive regulation of synapse assembly;GO:0051969|regulation of transmission of nerve impulse;GO:0060079|excitatory postsynaptic potential;GO:0060124|positive regulation of growth hormone secretion;GO:0061098|positive regulation of protein tyrosine kinase activity;GO:0097009|energy homeostasis;GO:0099170|postsynaptic modulation of chemical synaptic transmission;GO:0099175|regulation of postsynapse organization;GO:0120058|positive regulation of small intestinal transit;GO:0120162|positive regulation of cold-induced thermogenesis;GO:1903012|positive regulation of bone development;GO:1903672|positive regulation of sprouting angiogenesis;GO:1904000|positive regulation of eating behavior;GO:1904179|positive regulation of adipose tissue development;GO:1904306|positive regulation of gastro-intestinal system smooth muscle contraction;GO:1904346|positive regulation of gastric mucosal blood circulation;GO:1904349|positive regulation of small intestine smooth muscle contraction;GO:1905333|regulation of gastric motility;GO:1905564|positive regulation of vascular endothelial cell proliferation;GO:2000253|positive regulation of feeding behavior;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0030424|axon;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098794|postsynapse;GO:0098978|glutamatergic synapse;","GO:0001664|G protein-coupled receptor binding;GO:0005179|hormone activity;GO:0016608|growth hormone-releasing hormone activity;GO:0030296|protein tyrosine kinase activator activity;GO:0031768|ghrelin receptor binding;","K05254","GHRL; ghrelin"]
["ENSRNOG00000029128",1,0.064330438,9,0.581056737,0.110712834,-3.175105621,0.007029575,3.865224E-3,"down","yes","Cyp2d5","protein_coding","chr7:113899890-113904495:-","gi|56972326|gb|AAH88097.1|",2041,0,"Cytochrome P450, family 2, subfamily d, polypeptide 5 [Rattus norvegicus]","gi|203775|gb|M25143.1|RATCYP45J",1225,0,"Rat cytochrome P450CMF1b mRNA, complete cds","P12939",783,0,"Cytochrome P450 2D10",".",".",".",".","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0006082|organic acid metabolic process;GO:0006805|xenobiotic metabolic process;GO:0019369|arachidonic acid metabolic process;GO:0042178|xenobiotic catabolic process;","GO:0005737|cytoplasm;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0004497|monooxygenase activity;GO:0005506|iron ion binding;GO:0008395|steroid hydroxylase activity;GO:0016712|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0020037|heme binding;GO:0070330|aromatase activity;","K07414","CYP2D; cytochrome P450 family 2 subfamily D [EC:1.14.14.1]"]
["ENSRNOG00000033672",1,0.064330438,9,0.581056737,0.110712834,-3.175105621,0.007029575,3.865224E-3,"down","yes","Alpp","protein_coding","chr9:87765860-87768606:-","gi|672024257|ref|XP_002727285.2|",2535,0,"PREDICTED: alkaline phosphatase, placental-like [Rattus norvegicus]","gi|672024256|ref|XM_002727239.2|",1590,0,"PREDICTED: Rattus norvegicus alkaline phosphatase, placental (Alpp), mRNA","P24823",914,0,"Alkaline phosphatase, placental-like","XF0657",318,{"v":7e-100,"d":"7.00E-100"},"COG1785","pfam00245","Alk_phosphatase","Alkaline phosphatase.","GO:0016311|dephosphorylation;GO:0021915|neural tube development;GO:0022008|neurogenesis;GO:0035264|multicellular organism growth;GO:0036342|post-anal tail morphogenesis;","GO:0005886|plasma membrane;GO:0005903|brush border;GO:0009986|cell surface;GO:0030016|myofibril;GO:0031225|anchored component of membrane;","GO:0004035|alkaline phosphatase activity;","K01077","E3.1.3.1, phoA, phoB; alkaline phosphatase [EC:3.1.3.1]"]
["ENSRNOG00000065271",1,0.064330438,9,0.581056737,0.110712834,-3.175105621,0.007029575,3.865224E-3,"down","yes","ENSRNOG00000065271","protein_coding","chr1:127508068-127516078:-","gi|149057193|gb|EDM08516.1|",360,{"v":1E-35,"d":"1.00E-35"},"rCG24730 [Rattus norvegicus]","gi|672013852|ref|XM_003753294.3|",735,0,"PREDICTED: Rattus norvegicus family with sequence similarity 174, member B (Fam174b), mRNA","Q8K064",127,{"v":7e-32,"d":"7.00E-32"},"Membrane protein FAM174B",".",".",".",".","pfam06679","DUF1180","Protein of unknown function (DUF1180). This family consists of several hypothetical mammalian proteins of around 190 residues in length. The function of this family is unknown.",".",".",".",".","."]
["ENSRNOG00000066240",1,0.064330438,9,0.581056737,0.110712834,-3.175105621,0.007029575,3.865224E-3,"down","yes","ENSRNOG00000066240","lncRNA","chr15:24454978-24463251:-","gi|37361874|gb|AAQ91050.1|",170,{"v":1E-13,"d":"1.00E-13"},"LRRGT00094 [Rattus norvegicus]","gi|16596560|gb|AC079437.2|",563,0,"Rattus norvegicus strain Brown Norway chromosome 4 clone RP31-275K4, complete sequence",".",".",".",".",".",".",".",".","pfam10265","DUF2217","Uncharacterized conserved protein (DUF2217). This is a family of conserved proteins of from 500 - 600 residues found from worms to humans. Its function is not known.",".",".",".",".","."]
["ENSRNOG00000068905",1,0.064330438,9,0.581056737,0.110712834,-3.175105621,0.007029575,3.865224E-3,"down","yes","ENSRNOG00000068905","protein_coding","chr7:31598053-31650903:+","gi|576080555|ref|NP_001276655.1|",756,{"v":1e-151,"d":"1.00E-151"},"glyceraldehyde-3-phosphate dehydrogenase isoform 1 [Mus musculus]","gi|402691727|ref|NM_017008.4|",748,0,"Rattus norvegicus glyceraldehyde-3-phosphate dehydrogenase (Gapdh), mRNA","P16858",286,{"v":1E-150,"d":"1.00E-150"},"Glyceraldehyde-3-phosphate dehydrogenase","SPBC354.12",215,{"v":3e-109,"d":"3.00E-109"},"COG0057","pfam00044","Gp_dh_N","Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain. GAPDH is a tetrameric NAD-binding enzyme involved in glycolysis and glyconeogenesis. N-terminal domain is a Rossmann NAD(P) binding fold.",".",".",".",".","."]
["ENSRNOG00000050974",21,1.350939202,42,2.711598106,0.498207754,-1.005180619,0.007255907,3.978947E-3,"down","yes","AABR07030773.1","protein_coding","chr10:100253624-100258323:-","gi|269973887|ref|NP_001161756.1|",999,{"v":3E-134,"d":"3.00E-134"},"immune activating receptor CD300d2 precursor [Rattus norvegicus]","gi|269973886|ref|NM_001168284.1|",630,0,"Rattus norvegicus similar to dendritic cell-derived immunoglobulin(Ig)-like receptor 1, DIgR1 - mouse (RGD1561778), mRNA","Q7TSN2",251,{"v":2e-81,"d":"2.00E-81"},"CMRF35-like molecule",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000017884",9,0.578973944,24,1.549484632,0.373655815,-1.420218119,0.007617364,0.004164764,"down","yes","AABR07006160.1","protein_coding","chr1:204990642-204991949:-","gi|109459819|ref|XP_001073579.1|",739,{"v":8e-95,"d":"8.00E-95"},"PREDICTED: dnaJ homolog subfamily B member 6 [Rattus norvegicus]","gi|672014627|ref|XM_002725782.4|",695,0,"PREDICTED: Rattus norvegicus similar to DnaJ homolog subfamily B member 6 (Heat shock protein J2) (HSJ-2) (MRJ) (mDj4) (LOC690183), mRNA","Q6AYU3",282,{"v":5e-92,"d":"5.00E-92"},"DnaJ homolog subfamily B member 6","TVN0487",101,{"v":5e-24,"d":"5.00E-24"},"COG0484","pfam00226","DnaJ","DnaJ domain. DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.",".",".",".","K09512","DNAJB6; DnaJ homolog subfamily B member 6"]
["ENSRNOG00000020380",9,0.578973944,24,1.549484632,0.373655815,-1.420218119,0.007617364,0.004164764,"down","yes","Lgals7","protein_coding","chr1:84150252-84152015:+","gi|158517925|ref|NP_072104.2|",711,{"v":6e-92,"d":"6.00E-92"},"galectin-7 [Rattus norvegicus]","gi|672035697|ref|XM_006228670.2|",499,0,"PREDICTED: Rattus norvegicus lectin, galactoside-binding, soluble, 7 (Lgals7), transcript variant X2, mRNA","P97590",278,{"v":2e-93,"d":"2.00E-93"},"Galectin-7",".",".",".",".","pfam00337","Gal-bind_lectin","Galactoside-binding lectin. This family contains galactoside binding lectins.   The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).","GO:0006915|apoptotic process;GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0010628|positive regulation of gene expression;GO:0032689|negative regulation of interferon-gamma production;GO:2000562|negative regulation of CD4-positive, alpha-beta T cell proliferation;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005829|cytosol;","GO:0016936|galactoside binding;GO:0030246|carbohydrate binding;","K10092","LGALS7; galectin-7"]
["ENSRNOG00000007680",11,0.70763482,27,1.743170211,0.405947059,-1.300636503,0.008135265,4.432648E-3,"down","yes","Fhl5","protein_coding","chr5:38907946-38956552:-","gi|61556917|ref|NP_001013106.1|",1507,0,"four and a half LIM domains protein 5 [Rattus norvegicus]","gi|61556916|ref|NM_001013088.1|",938,0,"Rattus norvegicus four and a half LIM domains 5 (Fhl5), mRNA","Q6AXT1",585,0,"Four and a half LIM domains protein 5",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.","GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;GO:0030018|Z disc;","GO:0003712|transcription coregulator activity;GO:0003713|transcription coactivator activity;GO:0046872|metal ion binding;","K24415","FHL5, ACT; four and a half LIM domains protein 5"]
["ENSRNOG00000007270",15,0.964956573,33,2.130541369,0.45291614,-1.142684143,0.008248349,0.004490836,"down","yes","Il12rb2","protein_coding","chr4:96426842-96515289:-","gi|300795677|ref|NP_001178679.1|",4542,0,"interleukin-12 receptor subunit beta-2 precursor [Rattus norvegicus]","gi|672049893|ref|XM_006236613.2|",3214,0,"PREDICTED: Rattus norvegicus interleukin 12 receptor, beta 2 (Il12rb2), transcript variant X1, mRNA","P97378",1558,0,"Interleukin-12 receptor subunit beta-2",".",".",".",".","pfam06328","Lep_receptor_Ig","Ig-like C2-type domain. This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.","GO:0018108|peptidyl-tyrosine phosphorylation;GO:0019221|cytokine-mediated signaling pathway;GO:0032496|response to lipopolysaccharide;GO:0032729|positive regulation of interferon-gamma production;GO:0034097|response to cytokine;GO:0045622|regulation of T-helper cell differentiation;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0043235|receptor complex;","GO:0004896|cytokine receptor activity;GO:0019901|protein kinase binding;GO:0019955|cytokine binding;","K05064","IL12RB2; interleukin 12 receptor beta-2"]
["ENSRNOG00000042441",5,0.321652191,17,1.097551614,0.293063385,-1.770715366,0.008408645,0.004573314,"down","yes","Tpd52l3","protein_coding","chr1:227773724-227784467:+","gi|157822097|ref|NP_001099819.1|",803,{"v":5e-98,"d":"5.00E-98"},"tumor protein D55 [Rattus norvegicus]","gi|672040174|ref|XM_008760353.1|",1525,0,"PREDICTED: Rattus norvegicus tumor protein D55-like (LOC103690131), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam04201","TPD52","tumor protein D52 family. The hD52 gene was originally identified through its elevated expression level in human breast carcinoma. Cloning of D52 homologues from other species has indicated that D52 may play roles in calcium-mediated signal transduction and cell proliferation. Two human homologues of hD52, hD53 and hD54, have also been identified, demonstrating the existence of a novel gene/protein family. These proteins have an amino terminal coiled-coil that allows members to form homo- and heterodimers with each other.",".","GO:0005737|cytoplasm;",".",".","."]
["ENSRNOG00000067464",5,0.321652191,17,1.097551614,0.293063385,-1.770715366,0.008408645,0.004573314,"down","yes","Cysltr2","protein_coding","chr15:48189073-48304136:-","gi|19173778|ref|NP_596904.1|",1633,0,"cysteinyl leukotriene receptor 2 [Rattus norvegicus]","gi|672078647|ref|XM_008770842.1|",3512,0,"PREDICTED: Rattus norvegicus cysteinyl leukotriene receptor 2 (Cysltr2), transcript variant X1, mRNA","Q924T9",633,0,"Cysteinyl leukotriene receptor 2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.",".",".",".",".","."]
["ENSRNOG00000012467",2,0.128660876,11,0.710180456,0.181166456,-2.464612238,0.008892355,0.004816672,"down","yes","Il17a","protein_coding","chr9:23144402-23147889:+","gi|157823063|ref|NP_001100367.1|",696,{"v":1E-87,"d":"1.00E-87"},"interleukin-17A precursor [Rattus norvegicus]","gi|157823062|ref|NM_001106897.1|",1144,0,"Rattus norvegicus interleukin 17A (Il17a), mRNA","Q61453",257,{"v":3e-83,"d":"3.00E-83"},"Interleukin-17A",".",".",".",".","pfam06083","IL17","Interleukin-17. IL-17 is a potent proinflammatory cytokine produced by activated memory T cells. The IL-17 family is thought to represent a distinct signaling system that appears to have been highly conserved across vertebrate evolution.","GO:0002225|positive regulation of antimicrobial peptide production;GO:0002250|adaptive immune response;GO:0006954|inflammatory response;GO:0007219|Notch signaling pathway;GO:0010940|positive regulation of necrotic cell death;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032735|positive regulation of interleukin-12 production;GO:0032739|positive regulation of interleukin-16 production;GO:0032747|positive regulation of interleukin-23 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0043200|response to amino acid;GO:0045087|innate immune response;GO:0045672|positive regulation of osteoclast differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:0050832|defense response to fungus;GO:0060729|intestinal epithelial structure maintenance;GO:0071347|cellular response to interleukin-1;GO:0071385|cellular response to glucocorticoid stimulus;GO:0072537|fibroblast activation;GO:0097400|interleukin-17-mediated signaling pathway;GO:0097530|granulocyte migration;GO:1900017|positive regulation of cytokine production involved in inflammatory response;GO:1903348|positive regulation of bicellular tight junction assembly;GO:2000340|positive regulation of chemokine (C-X-C motif) ligand 1 production;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0009897|external side of plasma membrane;","GO:0003674|molecular_function;GO:0005125|cytokine activity;GO:0042803|protein homodimerization activity;GO:0046982|protein heterodimerization activity;","K05489","IL17A, CTLA8; interleukin 17A"]
["ENSRNOG00000020901",2,0.128660876,11,0.710180456,0.181166456,-2.464612238,0.008892355,0.004816672,"down","yes","S1pr5","protein_coding","chr8:19786663-19791795:-","gi|564362665|ref|XP_006242725.1|",1399,0,"PREDICTED: sphingosine 1-phosphate receptor 5 isoform X1 [Rattus norvegicus]","gi|31377520|ref|NM_021775.2|",2147,0,"Rattus norvegicus sphingosine-1-phosphate receptor 5 (S1pr5), mRNA","Q9JKM5",543,0,"Sphingosine 1-phosphate receptor 5",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0003376|sphingosine-1-phosphate receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0019222|regulation of metabolic process;GO:0045664|regulation of neuron differentiation;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0038036|sphingosine-1-phosphate receptor activity;","K04295","S1PR5, EDG8; sphingosine 1-phosphate receptor 5"]
["ENSRNOG00000037435",2,0.128660876,11,0.710180456,0.181166456,-2.464612238,0.008892355,0.004816672,"down","yes","Tmem196","protein_coding","chr6:140896576-140957435:+","gi|564357629|ref|XP_006240764.1|",701,{"v":2E-85,"d":"2.00E-85"},"PREDICTED: transmembrane protein 196 isoform X2 [Rattus norvegicus]","gi|672057410|ref|XM_006240702.2|",1800,0,"PREDICTED: Rattus norvegicus transmembrane protein 196 (Tmem196), transcript variant X2, mRNA","Q5HYL7",260,{"v":2e-81,"d":"2.00E-81"},"Transmembrane protein 196",".",".",".",".","pfam12271","Chs3p","Chitin synthase III catalytic subunit. This family of proteins is found in eukaryotes. Proteins in this family are typically between 288 and 332 amino acids in length. This family is the catalytic domain of chitin synthase III. Chitin is a major component of fungal cell walls and this enzyme is responsible for its formation.",".","GO:0016021|integral component of membrane;",".","K22195","TMEM196; transmembrane protein 196"]
["ENSRNOG00000042360",2,0.128660876,11,0.710180456,0.181166456,-2.464612238,0.008892355,0.004816672,"down","yes","Treml4","protein_coding","chr9:12721815-12743253:-","gi|564311158|ref|XP_006226779.1|",1081,{"v":3e-145,"d":"3.00E-145"},"PREDICTED: trem-like transcript 4 protein isoform X3 [Rattus norvegicus]","gi|255003765|ref|NM_001033922.2|",447,0,"Mus musculus triggering receptor expressed on myeloid cells-like 4 (Treml4), transcript variant 1, mRNA","Q3LRV9",338,{"v":4e-114,"d":"4.00E-114"},"Trem-like transcript 4 protein",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0002230|positive regulation of defense response to virus by host;GO:0002457|T cell antigen processing and presentation;GO:0006911|phagocytosis, engulfment;GO:0008104|protein localization;GO:0034157|positive regulation of toll-like receptor 7 signaling pathway;GO:0034165|positive regulation of toll-like receptor 9 signaling pathway;GO:0034181|positive regulation of toll-like receptor 13 signaling pathway;","GO:0005765|lysosomal membrane;GO:0005783|endoplasmic reticulum;GO:0010008|endosome membrane;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000066881",2,0.128660876,11,0.710180456,0.181166456,-2.464612238,0.008892355,0.004816672,"down","yes","ENSRNOG00000066881","protein_coding","chr13:2852897-2854568:+","gi|24981047|gb|AAH39826.1|",846,{"v":8e-113,"d":"8.00E-113"},"DDX6 protein [Homo sapiens]","gi|672061649|ref|XM_006242954.2|",523,0,"PREDICTED: Rattus norvegicus DEAD (Asp-Glu-Ala-Asp) box helicase 6 (Ddx6), transcript variant X4, mRNA","P54823",335,{"v":7e-112,"d":"7.00E-112"},"Probable ATP-dependent RNA helicase DDX6",".",".",".",".","pfam00270","DEAD","DEAD/DEAH box helicase. Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolizm, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.",".",".",".",".","."]
["ENSRNOG00000068642",2,0.128660876,11,0.710180456,0.181166456,-2.464612238,0.008892355,0.004816672,"down","yes","Slc6a20","protein_coding","chr8:123281472-123322573:-","gi|149018114|gb|EDL76755.1|",3050,0,"rCG25839 [Rattus norvegicus]","gi|298892765|emb|FQ211786.1|",2899,0,"Rattus norvegicus TL0AAA80YC01 mRNA sequence","Q64093",1173,0,"Sodium- and chloride-dependent transporter XTRP3","AF1995",147,{"v":3e-36,"d":"3.00E-36"},"COG0733","pfam00209","SNF","Sodium:neurotransmitter symporter family.",".",".",".",".","."]
["ENSRNOG00000011508",4,0.257321753,15,0.968427895,0.265710802,-1.912071215,0.009100074,4.923116E-3,"down","yes","ENSRNOG00000011508","protein_coding","chrX:60615682-60844832:+","gi|293362996|ref|XP_002730294.1|",4450,0,"PREDICTED: probable ribonuclease ZC3H12B [Rattus norvegicus]","gi|110347403|ref|NM_001034907.2|",2917,0,"Mus musculus zinc finger CCCH-type containing 12B (Zc3h12b), mRNA","Q5HYM0",1553,0,"Probable ribonuclease ZC3H12B",".",".",".",".","pfam11977","RNase_Zc3h12a","Zc3h12a-like Ribonuclease NYN domain. This domain is found in the Zc3h12a protein which has shown to be a ribonuclease that controls the stability of a set of inflammatory genes. It has been suggested that this domain belongs to the PIN domain superfamily. This domain has also been identified as part of the NYN domain family.","GO:0090502|RNA phosphodiester bond hydrolysis, endonucleolytic;","GO:0005634|nucleus;GO:0036464|cytoplasmic ribonucleoprotein granule;","GO:0003729|mRNA binding;GO:0004521|endoribonuclease activity;GO:0046872|metal ion binding;","K18668","ZC3H12, MCPIP; ribonuclease ZC3H12 [EC:3.1.-.-]"]
["ENSRNOG00000052803",4,0.257321753,15,0.968427895,0.265710802,-1.912071215,0.009100074,4.923116E-3,"down","yes","Klri1","protein_coding","chr4:163183669-163218870:-","gi|60593099|ref|NP_001012667.1|",1237,{"v":3e-168,"d":"3.00E-168"},"killer cell lectin-like receptor family I member 1 [Rattus norvegicus]","gi|298888087|emb|FQ233804.1|",1126,0,"Rattus norvegicus TL0AEA60YF14 mRNA sequence","Q5DT39",481,{"v":9E-170,"d":"9.00E-170"},"Killer cell lectin-like receptor subfamily I member 1",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type",".","GO:0005887|integral component of plasma membrane;","GO:0030246|carbohydrate binding;",".","."]
["ENSRNOG00000003595",3,0.192991315,13,0.839304176,0.22994204,-2.120657837,0.009391804,0.005066544,"down","yes","Lhx4","protein_coding","chr13:67877109-67927003:-","gi|157820803|ref|NP_001101818.1|",1473,0,"LIM/homeobox protein Lhx4 [Rattus norvegicus]","gi|157820802|ref|NM_001108348.1|",1414,0,"Rattus norvegicus LIM homeobox 4 (Lhx4), mRNA","P53776",567,0,"LIM/homeobox protein Lhx4","ECU06g0500",53.9,2e-07,"COG5576","pfam00046","Homeobox","Homeobox domain.","GO:0001890|placenta development;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008045|motor neuron axon guidance;GO:0008150|biological_process;GO:0009887|animal organ morphogenesis;GO:0021526|medial motor column neuron differentiation;GO:0030182|neuron differentiation;GO:0043066|negative regulation of apoptotic process;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005575|cellular_component;GO:0005634|nucleus;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0008327|methyl-CpG binding;GO:0043565|sequence-specific DNA binding;GO:0046872|metal ion binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09374","LHX3_4; LIM homeobox protein 3/4"]
["ENSRNOG00000017002",3,0.192991315,13,0.839304176,0.22994204,-2.120657837,0.009391804,0.005066544,"down","yes","Adrb1","protein_coding","chr1:255771597-255807259:+","gi|220671|dbj|BAA00527.1|",1651,0,"beta-1 adrenergic receptor [Rattus norvegicus]","gi|74013488|gb|AC158549.8|",2776,0,"Mus musculus chromosome 19, clone RP24-216K4, complete sequence","P34971",638,0,"Beta-1 adrenergic receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001996|positive regulation of heart rate by epinephrine-norepinephrine;GO:0001997|positive regulation of the force of heart contraction by epinephrine-norepinephrine;GO:0002024|diet induced thermogenesis;GO:0002025|norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure;GO:0003061|positive regulation of the force of heart contraction by norepinephrine;GO:0003084|positive regulation of systemic arterial blood pressure;GO:0005980|glycogen catabolic process;GO:0006915|apoptotic process;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007266|Rho protein signal transduction;GO:0007568|aging;GO:0007613|memory;GO:0009409|response to cold;GO:0010460|positive regulation of heart rate;GO:0019233|sensory perception of pain;GO:0031649|heat generation;GO:0033365|protein localization to organelle;GO:0035811|negative regulation of urine volume;GO:0040015|negative regulation of multicellular organism growth;GO:0042060|wound healing;GO:0042596|fear response;GO:0043065|positive regulation of apoptotic process;GO:0043547|positive regulation of GTPase activity;GO:0045187|regulation of circadian sleep/wake cycle, sleep;GO:0045762|positive regulation of adenylate cyclase activity;GO:0045986|negative regulation of smooth muscle contraction;GO:0046878|positive regulation of saliva secretion;GO:0050873|brown fat cell differentiation;GO:0051924|regulation of calcium ion transport;GO:0055088|lipid homeostasis;GO:0060078|regulation of postsynaptic membrane potential;GO:0060080|inhibitory postsynaptic potential;GO:0061051|positive regulation of cell growth involved in cardiac muscle cell development;GO:0071880|adenylate cyclase-activating adrenergic receptor signaling pathway;GO:0086004|regulation of cardiac muscle cell contraction;GO:0106071|positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0120162|positive regulation of cold-induced thermogenesis;GO:1900135|positive regulation of renin secretion into blood stream;GO:1900273|positive regulation of long-term synaptic potentiation;GO:1905665|positive regulation of calcium ion import across plasma membrane;GO:2001259|positive regulation of cation channel activity;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005769|early endosome;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098794|postsynapse;","GO:0004930|G protein-coupled receptor activity;GO:0004940|beta1-adrenergic receptor activity;GO:0005085|guanyl-nucleotide exchange factor activity;GO:0005515|protein binding;GO:0030165|PDZ domain binding;GO:0031694|alpha-2A adrenergic receptor binding;GO:0043176|amine binding;GO:0046982|protein heterodimerization activity;GO:0099579|G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential;","K04141","ADRB1; adrenergic receptor beta-1"]
["ENSRNOG00000006324",10,0.643304382,25,1.614046491,0.398566203,-1.327108714,0.009697284,0.005221968,"down","yes","ENSRNOG00000006324","protein_coding","chr8:5758935-5828092:+","gi|530719556|ref|NP_001269016.1|",1844,0,"short transient receptor potential channel 6 isoform 3 [Mus musculus]","gi|16758329|ref|NM_053559.1|",1125,0,"Rattus norvegicus transient receptor potential cation channel, subfamily C, member 6 (Trpc6), mRNA","Q61143",680,0,"Short transient receptor potential channel 6",".",".",".",".","pfam08344","TRP_2","Transient receptor ion channel II. This domain is found in the transient receptor ion channel (Trp) family of proteins. There is strong evidence that Trp proteins are structural elements of calcium-ion entry channels activated by G protein-coupled receptors. This domain does not tend to appear with the TRP domain (pfam06011) but is often found to the C-terminus of Ankyrin repeats (pfam00023).","GO:0006828|manganese ion transport;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007338|single fertilization;GO:0007568|aging;GO:0010800|positive regulation of peptidyl-threonine phosphorylation;GO:0030182|neuron differentiation;GO:0032414|positive regulation of ion transmembrane transporter activity;GO:0045666|positive regulation of neuron differentiation;GO:0050774|negative regulation of dendrite morphogenesis;GO:0051480|regulation of cytosolic calcium ion concentration;GO:0051928|positive regulation of calcium ion transport;GO:0070301|cellular response to hydrogen peroxide;GO:0070588|calcium ion transmembrane transport;GO:0071456|cellular response to hypoxia;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0034703|cation channel complex;GO:0036057|slit diaphragm;","GO:0003779|actin binding;GO:0005216|ion channel activity;GO:0005261|cation channel activity;GO:0005262|calcium channel activity;GO:0005515|protein binding;GO:0015279|store-operated calcium channel activity;GO:0030276|clathrin binding;GO:0042803|protein homodimerization activity;GO:0042805|actinin binding;GO:0051117|ATPase binding;GO:0070679|inositol 1,4,5 trisphosphate binding;","K04969","TRPC6; transient receptor potential cation channel subfamily C member 6"]
["ENSRNOG00000032877",10,0.643304382,25,1.614046491,0.398566203,-1.327108714,0.009697284,0.005221968,"down","yes","AABR07072261.1","protein_coding","chr11:80408680-80409072:+","gi|30109302|gb|AAH51205.1|",671,{"v":4e-88,"d":"4.00E-88"},"Rps15a protein, partial [Mus musculus]","gi|298901578|emb|FQ221720.1|",369,0,"Rattus norvegicus TL0ADA32YK23 mRNA sequence","P62246",261,{"v":3e-89,"d":"3.00E-89"},"40S ribosomal protein S15a","YJL190c",212,{"v":4E-70,"d":"4.00E-70"},"COG0096","pfam00410","Ribosomal_S8","Ribosomal protein S8.","GO:0006412|translation;",".",".",".","."]
["ENSRNOG00000070563",16,1.029287011,34,2.195103228,0.468901416,-1.092643461,0.009699496,5.2221739999999996E-3,"down","yes","ENSRNOG00000070563","lncRNA","chr16:50955262-50958227:+",".",".",".",".","gi|56404121|gb|AC144926.6|",585,0,"Mus musculus chromosome 8, clone RP23-8E24, complete sequence",".",".",".",".",".",".",".",".","pfam04904","NCD1","NAB conserved region 1 (NCD1). Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of transcription factors. This region consists of the N-terminal NAB conserved region 1, which interacts with the EGR1 inhibitory domain (R1). It may also mediate multimerization.",".",".",".",".","."]
["ENSRNOG00000001707",14,0.900626135,31,2.001417649,0.4499941,-1.152022008,0.009961082,0.005353926,"down","yes","Vwa5b2","protein_coding","chr11:80306350-80323220:-","gi|672071558|ref|XP_008767045.1|",5659,0,"PREDICTED: von Willebrand factor A domain-containing protein 5B2 isoform X7 [Rattus norvegicus]","gi|197387258|ref|NM_001134535.1|",4447,0,"Rattus norvegicus von Willebrand factor A domain containing 5B2 (Vwa5b2), mRNA",".",".",".",".",".",".",".",".","pfam13768","VWA_3","von Willebrand factor type A domain.",".",".",".","K24510","VWA5; von Willebrand factor A domain-containing protein 5"]
["ENSRNOG00000064054",12,0.771965258,28,1.80773207,0.427035218,-1.227573041,9.995515E-3,0.005370917,"down","yes","ENSRNOG00000064054","lncRNA","chr7:108757729-108759258:-",".",".",".",".","gi|672022071|ref|XR_601909.1|",784,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102556690 (LOC102556690), ncRNA",".",".",".",".",".",".",".",".","pfam08670","MEKHLA","MEKHLA domain. The MEKHLA domain shares similarity with the PAS domain and is found in the 3' end of plant HD-ZIP III homeobox genes, and bacterial proteins.",".",".",".",".","."]
["ENSRNOG00000063658",7,0.450313067,20,1.291237193,0.348745428,-1.519753792,0.010400575,0.005579646,"down","yes","ENSRNOG00000063658","lncRNA","chr3:116404250-116413702:-","gi|149036607|gb|EDL91225.1|",228,{"v":3e-19,"d":"3.00E-19"},"rCG56442 [Rattus norvegicus]","gi|256985244|gb|AC121664.5|",1387,0,"Rattus norvegicus CH230-383I17 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam10192","GpcrRhopsn4","Rhodopsin-like GPCR transmembrane domain. This region of 270 amino acids is the seven transmembrane alpha-helical domains included within five GPCRRHODOPSN4 motifs of a G-protein-coupled-receptor (GPCR) protein, conserved from nematodes to humans. GPCRs are integral membrane receptors whose intracellular actions are mediated by signalling pathways involving G proteins and downstream secondary messengers.",".",".",".",".","."]
["ENSRNOG00000005105",0,0.032165219,7,0.451933018,0.071172536,-3.812535541,0.010591733,0.005656163,"down","yes","Sun3","protein_coding","chr14:83710140-83735830:-","gi|564317332|ref|XP_006221904.1|",1730,0,"PREDICTED: SUN domain-containing protein 3 isoform X1 [Rattus norvegicus]","gi|672028138|ref|XM_008766646.1|",3002,0,"PREDICTED: Rattus norvegicus Sad1 and UNC84 domain containing 3 (Sun3), transcript variant X2, mRNA","Q5SS91",639,0,"SUN domain-containing protein 3",".",".",".",".","pfam07738","Sad1_UNC","Sad1 / UNC-like C-terminal. The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.","GO:0006998|nuclear envelope organization;","GO:0005635|nuclear envelope;GO:0005639|integral component of nuclear inner membrane;GO:0034993|meiotic nuclear membrane microtubule tethering complex;","GO:0043495|protein membrane anchor;","K21874","SUN3; SUN domain-containing protein 3"]
["ENSRNOG00000006311",0,0.032165219,7,0.451933018,0.071172536,-3.812535541,0.010591733,0.005656163,"down","yes","Ccr9","protein_coding","chr8:123395813-123413969:+","gi|27229230|ref|NP_758832.1|",1756,0,"C-C chemokine receptor type 9 [Rattus norvegicus]","gi|60551362|gb|BC091115.1|",2472,0,"Rattus norvegicus chemokine (C-C motif) receptor 9, mRNA (cDNA clone MGC:108562 IMAGE:7381553), complete cds","Q9WUT7",674,0,"C-C chemokine receptor type 9",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0002305|CD8-positive, gamma-delta intraepithelial T cell differentiation;GO:0006935|chemotaxis;GO:0006955|immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0019722|calcium-mediated signaling;GO:0060326|cell chemotaxis;GO:0070098|chemokine-mediated signaling pathway;","GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0016493|C-C chemokine receptor activity;GO:0019957|C-C chemokine binding;","K04184","CCR9, CDw199; C-C chemokine receptor type 9"]
["ENSRNOG00000013681",0,0.032165219,7,0.451933018,0.071172536,-3.812535541,0.010591733,0.005656163,"down","yes","Kcns1","protein_coding","chr3:152835644-152842960:-","gi|16758838|ref|NP_446406.1|",2212,0,"potassium voltage-gated channel subfamily S member 1 [Rattus norvegicus]","gi|16758837|ref|NM_053954.1|",2687,0,"Rattus norvegicus potassium voltage-gated channel, modifier subfamily S, member 1 (Kcns1), mRNA","O88758",856,0,"Potassium voltage-gated channel subfamily S member 1","PA1496",85.1,{"v":4e-17,"d":"4.00E-17"},"COG1226","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0006813|potassium ion transport;GO:0051260|protein homooligomerization;GO:0071805|potassium ion transmembrane transport;GO:1902259|regulation of delayed rectifier potassium channel activity;","GO:0005886|plasma membrane;GO:0008076|voltage-gated potassium channel complex;GO:0016021|integral component of membrane;GO:0048471|perinuclear region of cytoplasm;","GO:0005249|voltage-gated potassium channel activity;GO:0005251|delayed rectifier potassium channel activity;GO:0015459|potassium channel regulator activity;","K04931","KCNS1, KV9.1; potassium voltage-gated channel delayed-rectifier subfamily S member 1"]
["ENSRNOG00000018528",0,0.032165219,7,0.451933018,0.071172536,-3.812535541,0.010591733,0.005656163,"down","yes","Nrl","protein_coding","chr15:29008104-29009832:-","gi|157822971|ref|NP_001099506.1|",957,{"v":4e-128,"d":"4.00E-128"},"neural retina-specific leucine zipper protein [Rattus norvegicus]","gi|672078022|ref|XM_006251937.2|",717,0,"PREDICTED: Rattus norvegicus neural retina leucine zipper (Nrl), transcript variant X3, mRNA","P54846",347,{"v":3e-119,"d":"3.00E-119"},"Neural retina-specific leucine zipper protein",".",".",".",".","pfam03131","bZIP_Maf","bZIP Maf transcription factor. Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerization and DNA binding property. Thus, this family is probably related to pfam00170. This family also includes the DNA_binding domain of Skn-1, this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer.","GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0010628|positive regulation of gene expression;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046548|retinal rod cell development;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0043522|leucine zipper domain binding;GO:1990837|sequence-specific double-stranded DNA binding;GO:1990841|promoter-specific chromatin binding;","K09038","NRL; neural retina-specific leucine zipper protein"]
["ENSRNOG00000021945",0,0.032165219,7,0.451933018,0.071172536,-3.812535541,0.010591733,0.005656163,"down","yes","Ccdc184","protein_coding","chr7:129298212-129304494:+","gi|67846094|ref|NP_001020080.1|",853,{"v":2e-104,"d":"2.00E-104"},"coiled-coil domain-containing protein 184 [Rattus norvegicus]","gi|77377275|gb|AC105982.10|",1361,0,"Mus musculus chromosome 15, clone RP24-159I1, complete sequence","Q4V8F1",333,{"v":8e-106,"d":"8.00E-106"},"Coiled-coil domain-containing protein 184",".",".",".",".","pfam15498","Dendrin","Nephrin and CD2AP-binding protein, Dendrin. Dendrin is a family of eukaryotic proteins found in the podocytes of the kidneys. Dendrin, originally identified in telencephalic dendrites, is a constituent of the slit diaphragm, SD, complex of podocytes, where it directly binds to nephrin and CD2AP. Kidney podocytes and their slit diaphragms (SDs) form the final barrier to urinary protein loss. SD proteins also participate in intracellular signalling pathways. Dendrin appears to prevent programmed cell death (apoptosis) through its binding to nephrin. The SD protein nephrin serves as a component of a signalling complex that directly links podocyte junctional integrity to actin cytoskeletal dynamics. Thus, dendrin is identified as an SD family with proapoptotic signalling properties that accumulates in the podocyte nucleus in response to glomerular injury.",".","GO:0005737|cytoplasm;",".",".","."]
["ENSRNOG00000024693",0,0.032165219,7,0.451933018,0.071172536,-3.812535541,0.010591733,0.005656163,"down","yes","Zfp831","protein_coding","chr3:163438006-163509095:+","gi|564344832|ref|XP_006235776.1|",7535,0,"PREDICTED: zinc finger protein 831 isoform X1 [Rattus norvegicus]","gi|672047934|ref|XM_008762455.1|",5021,0,"PREDICTED: Rattus norvegicus similar to C20orf174 (RGD1565819), transcript variant X2, mRNA","Q5JPB2",1285,0,"Zinc finger protein 831","SPAC25B8.19c",53.1,1e-06,"COG5048","pfam13465","zf-H2C2_2","Zinc-finger double domain.",".",".",".",".","."]
["ENSRNOG00000033929",0,0.032165219,7,0.451933018,0.071172536,-3.812535541,0.010591733,0.005656163,"down","yes","Stfa2l1","protein_coding","chr11:64440792-64444858:-","gi|51889722|ref|NP_001004129.1|",544,{"v":1e-69,"d":"1.00E-69"},"stefin-3 [Rattus norvegicus]","gi|51889721|ref|NM_001004129.1|",312,{"v":3e-161,"d":"3.00E-161"},"Rattus norvegicus stefin A2-like 1 (Stfa2l1), mRNA","P35173",162,{"v":7e-51,"d":"7.00E-51"},"Stefin-3",".",".",".",".","pfam00031","Cystatin","Cystatin domain. Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 are related to this family but have not been included.","GO:0010951|negative regulation of endopeptidase activity;","GO:0005829|cytosol;","GO:0004869|cysteine-type endopeptidase inhibitor activity;",".","."]
["ENSRNOG00000037171",0,0.032165219,7,0.451933018,0.071172536,-3.812535541,0.010591733,0.005656163,"down","yes","Tdgf1","protein_coding","chr8:110925024-110930308:-","gi|293361382|ref|XP_001056317.2|",881,{"v":1e-118,"d":"1.00E-118"},"PREDICTED: teratocarcinoma-derived growth factor 1 [Rattus norvegicus]","gi|672063547|ref|XM_001056317.4|",442,0,"PREDICTED: Rattus norvegicus teratocarcinoma-derived growth factor 1 (Tdgf1), mRNA","P51865",298,{"v":2e-102,"d":"2.00E-102"},"Teratocarcinoma-derived growth factor",".",".",".",".","pfam09443","CFC","Cripto_Frl-1_Cryptic (CFC). CFC domain is one half of the membrane protein Cripto, a protein overexpressed in many tumors and structurally similar to the C-terminal extracellular portions of Jagged 1 and Jagged 2. CFC is approx 40-residues long, compacted by three internal disulphide bridges, and binds Alk4 via a hydrophobic patch. CFC is structurally homologous to the VWFC-like domain.","GO:0001568|blood vessel development;GO:0001570|vasculogenesis;GO:0001701|in utero embryonic development;GO:0001763|morphogenesis of a branching structure;GO:0001954|positive regulation of cell-matrix adhesion;GO:0002042|cell migration involved in sprouting angiogenesis;GO:0007368|determination of left/right symmetry;GO:0007369|gastrulation;GO:0007507|heart development;GO:0008150|biological_process;GO:0008284|positive regulation of cell proliferation;GO:0008595|anterior/posterior axis specification, embryo;GO:0009948|anterior/posterior axis specification;GO:0009952|anterior/posterior pattern specification;GO:0009966|regulation of signal transduction;GO:0010595|positive regulation of endothelial cell migration;GO:0018105|peptidyl-serine phosphorylation;GO:0030334|regulation of cell migration;GO:0030335|positive regulation of cell migration;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0035729|cellular response to hepatocyte growth factor stimulus;GO:0038092|nodal signaling pathway;GO:0043066|negative regulation of apoptotic process;GO:0043406|positive regulation of MAP kinase activity;GO:0043410|positive regulation of MAPK cascade;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048146|positive regulation of fibroblast proliferation;GO:0048856|anatomical structure development;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0055007|cardiac muscle cell differentiation;GO:0071346|cellular response to interferon-gamma;GO:0071354|cellular response to interleukin-6;GO:0071356|cellular response to tumor necrosis factor;GO:0071364|cellular response to epidermal growth factor stimulus;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0009986|cell surface;GO:0016324|apical plasma membrane;GO:0019897|extrinsic component of plasma membrane;GO:0045121|membrane raft;GO:0048471|perinuclear region of cytoplasm;","GO:0003674|molecular_function;GO:0005102|signaling receptor binding;GO:0008083|growth factor activity;GO:0015026|coreceptor activity;GO:0017147|Wnt-protein binding;GO:0038100|nodal binding;GO:0070697|activin receptor binding;GO:0070698|type I activin receptor binding;","K25455","TDGF1; teratocarcinoma-derived growth factor 1"]
["ENSRNOG00000046790",0,0.032165219,7,0.451933018,0.071172536,-3.812535541,0.010591733,0.005656163,"down","yes","AABR07040887.1","pseudogene","chrX:105356293-105359985:-","gi|293351123|ref|XP_001056753.2|",2324,0,"PREDICTED: LOW QUALITY PROTEIN: insulin receptor substrate 4 [Rattus norvegicus]","gi|672032659|ref|XM_001056753.4|",3619,0,"PREDICTED: Rattus norvegicus insulin receptor substrate 4 (Irs4), mRNA","Q9Z0Y7",704,0,"Insulin receptor substrate 4",".",".",".",".","pfam02174","IRS","PTB domain (IRS-1 type).","GO:0008286|insulin receptor signaling pathway;GO:0048009|insulin-like growth factor receptor signaling pathway;","GO:0032991|protein-containing complex;","GO:0019904|protein domain specific binding;","K17446","IRS4; insulin receptor substrate 4"]
["ENSRNOG00000047464",0,0.032165219,7,0.451933018,0.071172536,-3.812535541,0.010591733,0.005656163,"down","yes","AABR07060886.1","protein_coding","chr4:102343816-102344432:-","gi|149037293|gb|EDL91768.1|",568,{"v":1e-72,"d":"1.00E-72"},"rCG64259, partial [Rattus norvegicus]","gi|51873868|gb|BC080787.1|",250,{"v":1e-126,"d":"1.00E-126"},"Mus musculus immunoglobulin kappa chain complex, mRNA (cDNA clone MGC:91220 IMAGE:4206216), complete cds","P01658",173,{"v":2e-54,"d":"2.00E-54"},"Ig kappa chain V-III region MOPC 321",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000064045",0,0.032165219,7,0.451933018,0.071172536,-3.812535541,0.010591733,0.005656163,"down","yes","ENSRNOG00000064045","lncRNA","chr13:77289944-77331406:-",".",".",".",".","gi|55468796|gb|AC133891.13|",198,{"v":2e-97,"d":"2.00E-97"},"Mus musculus chromosome 1, clone RP23-287C17, complete sequence",".",".",".",".",".",".",".",".","pfam14052","Caps_assemb_Wzi","Capsule assembly protein Wzi. Many bacteria are covered in a layer of surface-associated polysaccharide called the capsule. These capsules can be divided into four groups depending upon the organisation of genes responsible for capsule assembly, the assembly pathway and regulation. This family plays a role in group 1 capsule biosynthesis. It is likely to be involved in the later stages of capsule assembly. It is likely to consist of a beta-barrel structure.",".",".",".",".","."]
["ENSRNOG00000064453",0,0.032165219,7,0.451933018,0.071172536,-3.812535541,0.010591733,0.005656163,"down","yes","ENSRNOG00000064453","lncRNA","chr9:76454645-76457883:-",".",".",".",".","gi|354795044|gb|JN959545.1|",1198,0,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Cryba2:tm1e(EUCOMM)Wtsi tm1e(EUCOMM)Hmgu; transgenic",".",".",".",".",".",".",".",".","pfam04767","Pox_F17","DNA-binding 11 kDa phosphoprotein. Family of poxvirus proteins required for virus morphogenesis. Protein function necessary for proteolytic processing of the major viral structural proteins, P4a and P4b.",".",".",".",".","."]
["ENSRNOG00000065009",0,0.032165219,7,0.451933018,0.071172536,-3.812535541,0.010591733,0.005656163,"down","yes","U7","snRNA","chr7:51474280-51474337:+",".",".",".",".","gi|354790091|gb|JN954592.1|",40,{"v":5e-11,"d":"5.00E-11"},"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Tspan8:tm1a(EUCOMM)Hmgu; transgenic",".",".",".",".",".",".",".",".","pfam03028","Dynein_heavy","Dynein heavy chain and region D6 of dynein motor. This family represents the C-terminal region of dynein heavy chain. The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained.",".",".",".",".","."]
["ENSRNOG00000065026",0,0.032165219,7,0.451933018,0.071172536,-3.812535541,0.010591733,0.005656163,"down","yes","ENSRNOG00000065026","protein_coding","chr15:18052150-18059581:-","gi|564385416|ref|XP_006251730.1|",1079,{"v":1e-143,"d":"1.00E-143"},"PREDICTED: disks large homolog 5 isoform X2 [Rattus norvegicus]","gi|672077720|ref|XM_006251670.2|",1112,0,"PREDICTED: Rattus norvegicus similar to RIKEN cDNA 1700001F09 (LOC498465), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam04822","Takusan","Takusan. This domain is named takusan, which is a Japanese word meaning 'many'. Members of this family regulate synaptic activity.",".",".",".",".","."]
["ENSRNOG00000067237",0,0.032165219,7,0.451933018,0.071172536,-3.812535541,0.010591733,0.005656163,"down","yes","ENSRNOG00000067237","lncRNA","chr1:1347392-1356446:+","gi|582833|emb|CAA43596.1|",667,{"v":6e-78,"d":"6.00E-78"},"unnamed protein product [Rattus norvegicus]","gi|113205092|gb|AC108550.6|",703,0,"Rattus norvegicus BAC CH230-194A5 () complete sequence","P11260",114,{"v":2e-25,"d":"2.00E-25"},"LINE-1 retrotransposable element ORF1 protein",".",".",".",".","pfam02994","Transposase_22","L1 transposable element.",".",".",".",".","."]
["ENSRNOG00000067531",0,0.032165219,7,0.451933018,0.071172536,-3.812535541,0.010591733,0.005656163,"down","yes","ENSRNOG00000067531","lncRNA","chr5:46574277-46575259:+","gi|31544940|gb|AAH53424.1|",169,{"v":1e-12,"d":"1.00E-12"},"Sip1 protein [Mus musculus]","gi|48675505|gb|AC140426.3|",151,{"v":1e-71,"d":"1.00E-71"},"Mus musculus BAC clone RP24-98A17 from chromosome 14, complete sequence",".",".",".",".",".",".",".",".","pfam15045","Clathrin_bdg","Clathrin-binding box of Aftiphilin, vesicle trafficking. Aftiphilin forms a stable complex with p200 and gamma-synergin. This family contains a clathrin box, with two identified clathrin-binding motifs. This family of proteins is found in eukaryotes.",".",".",".",".","."]
["ENSRNOG00000068784",0,0.032165219,7,0.451933018,0.071172536,-3.812535541,0.010591733,0.005656163,"down","yes","ENSRNOG00000068784","protein_coding","chr7:132812625-132817043:-","gi|293348969|ref|XP_002727023.1|",2032,0,"PREDICTED: keratin, type II cytoskeletal 6A [Rattus norvegicus]","gi|155369695|ref|NM_001101007.1|",2085,0,"Rattus norvegicus similar to keratin complex 2, basic, gene 6a (LOC683313), mRNA","Q4FZU2",757,0,"Keratin, type II cytoskeletal 6A",".",".",".",".","pfam00038","Filament","Intermediate filament protein.",".",".",".",".","."]
["ENSRNOG00000071072",0,0.032165219,7,0.451933018,0.071172536,-3.812535541,0.010591733,0.005656163,"down","yes","ENSRNOG00000071072","lncRNA","chr1:133998663-134019154:-","gi|148691168|gb|EDL23115.1|",192,{"v":4e-15,"d":"4.00E-15"},"mCG145372, partial [Mus musculus]","gi|34221823|emb|AL928693.9|",108,{"v":1e-47,"d":"1.00E-47"},"Mouse DNA sequence from clone RP23-407K8 on chromosome 2, complete sequence","P46935",52.8,4e-07,"E3 ubiquitin-protein ligase NEDD4",".",".",".",".","pfam02027","RolB_RolC","RolB/RolC glucosidase family. This family of proteins includes RolB and RolC. RolC releases cytokinins from glucoside conjugates. Whereas RolB hydrolyses indole glucosides.",".",".",".",".","."]
["ENSRNOG00000067410",17,1.093617449,35,2.259665088,0.483973247,-1.047000795,0.01126171,0.0059854,"down","yes","ENSRNOG00000067410","lncRNA","chr17:5108836-5114740:-",".",".",".",".","gi|672029720|ref|XR_598009.1|",1338,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102548402 (LOC102548402), transcript variant X3, ncRNA",".",".",".",".",".",".",".",".","pfam11145","DUF2921","Protein of unknown function (DUF2921). This eukaryotic family of proteins has no known function.",".",".",".",".","."]
["ENSRNOG00000069880",17,1.093617449,35,2.259665088,0.483973247,-1.047000795,0.01126171,0.0059854,"down","yes","ENSRNOG00000069880","lncRNA","chr8:48502706-48590177:+","gi|344257654|gb|EGW13758.1|",127,9e-06,"hypothetical protein I79_022866 [Cricetulus griseus]","gi|672061751|ref|XR_593871.1|",695,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103693075 (LOC103693075), ncRNA",".",".",".",".",".",".",".",".","pfam04621","ETS_PEA3_N","PEA3 subfamily ETS-domain transcription factor N terminal domain. The N terminus of the PEA3 transcription factors is implicated in transactivation and in inhibition of DNA binding. Transactivation is potentiated by activation of the Ras/MAP kinase and protein kinase A signalling cascades. The N terminal region contains conserved MAP kinase phosphorylation sites.",".",".",".",".","."]
["ENSRNOG00000015383",6,0.385982629,18,1.162113474,0.332138503,-1.59014312,0.011988492,0.006352165,"down","yes","Asxl3","protein_coding","chr18:13593985-13762427:+","gi|569003462|ref|XP_006525803.1|",9784,0,"PREDICTED: putative Polycomb group protein ASXL3 isoform X3 [Mus musculus]","gi|672082867|ref|XR_596915.1|",7534,0,"PREDICTED: Rattus norvegicus additional sex combs like transcriptional regulator 3 (Asxl3), transcript variant X3, misc_RNA","Q8C4A5",3773,0,"Putative Polycomb group protein ASXL3",".",".",".",".","pfam13919","ASXH","Asx homology domain. A conserved alpha helical domain with a characteristic LXXLL motif. The LXXLL motif is detected in diverse transcription factors, coactivators and corepressors and is implicated in mediating interactions between them. The ASXH domain is found in animals, fungi and plants and is predicted to play a role in mediating contact between transcription factors and chromatin-associated complexes. In Drosophila Asx and Human ASXL1, the ASXH domain is predicted to mediate interactions with the Calypso and BAP1 deubiquitinases (DUBs) which further belong to the UCHL5/UCH37 clade of DUBs.","GO:0051055|negative regulation of lipid biosynthetic process;",".","GO:0003677|DNA binding;GO:0046872|metal ion binding;",".","."]
["ENSRNOG00000023828",6,0.385982629,18,1.162113474,0.332138503,-1.59014312,0.011988492,0.006352165,"down","yes","ENSRNOG00000023828","protein_coding","chr7:107838080-107845981:-","gi|392341530|ref|XP_003754360.1|",3590,0,"PREDICTED: uncharacterized protein LOC680875 [Rattus norvegicus]","gi|672022041|ref|XM_008776501.1|",2532,0,"PREDICTED: Rattus norvegicus similar to dystonin isoform 1 (LOC680875), transcript variant X2, mRNA","Q9UPN3",68.2,{"v":4e-10,"d":"4.00E-10"},"Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5",".",".",".",".","pfam02187","GAS2","Growth-Arrest-Specific Protein 2 Domain.","GO:0032886|regulation of microtubule-based process;GO:0042060|wound healing;GO:0045104|intermediate filament cytoskeleton organization;GO:0051893|regulation of focal adhesion assembly;","GO:0005737|cytoplasm;GO:0005874|microtubule;GO:0005882|intermediate filament;GO:0015629|actin cytoskeleton;GO:0016020|membrane;","GO:0005198|structural molecule activity;GO:0008017|microtubule binding;",".","."]
["ENSRNOG00000007943",1,0.064330438,8,0.516494877,0.124551938,-3.005180619,0.013243279,0.006956997,"down","yes","Gsdma","protein_coding","chr10:83627051-83639543:+","gi|157819321|ref|NP_001101767.1|",1994,0,"gasdermin-A [Rattus norvegicus]","gi|157819320|ref|NM_001108297.1|",2910,0,"Rattus norvegicus gasdermin A (Gsdma), mRNA","Q9EST1",720,0,"Gasdermin-A",".",".",".",".","pfam04598","Gasdermin","Gasdermin family. The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein","GO:0006915|apoptotic process;GO:0042742|defense response to bacterium;GO:0070269|pyroptosis;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0048471|perinuclear region of cytoplasm;","GO:0001786|phosphatidylserine binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0070273|phosphatidylinositol-4-phosphate binding;","K22141","GSDMA; gasdermin-A"]
["ENSRNOG00000008439",1,0.064330438,8,0.516494877,0.124551938,-3.005180619,0.013243279,0.006956997,"down","yes","Gprc5d","protein_coding","chr4:167943523-167955616:-","gi|157823819|ref|NP_001102724.1|",1460,0,"G-protein coupled receptor family C group 5 member D [Rattus norvegicus]","gi|157823818|ref|NM_001109254.1|",1402,0,"Rattus norvegicus G protein-coupled receptor, class C, group 5, member D (Gprc5d), mRNA","Q9JIL6",565,0,"G-protein coupled receptor family C group 5 member D",".",".",".",".","pfam00003","7tm_3","7 transmembrane sweet-taste receptor of 3 GCPR. This is a domain of seven transmembrane regions that forms the C-terminus of some subclass 3 G-coupled-protein receptors. It is often associated with a downstream cysteine-rich linker domain, NCD3G pfam07562, which is the human sweet-taste receptor, and the N-terminal domain, ANF_receptor pfam01094. The seven TM regions assemble in such a way as to produce a docking pocket into which such molecules as cyclamate and lactisole have been found to bind and consequently confer the taste of sweetness.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0032147|activation of protein kinase activity;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0043235|receptor complex;GO:0070062|extracellular exosome;","GO:0004930|G protein-coupled receptor activity;GO:0030295|protein kinase activator activity;","K04621","GPRC5D; G protein-coupled receptor family C group 5 member D"]
["ENSRNOG00000013835",1,0.064330438,8,0.516494877,0.124551938,-3.005180619,0.013243279,0.006956997,"down","yes","Timm8a2","protein_coding","chr15:99127384-99131155:+","gi|157821785|ref|NP_001102899.1|",446,{"v":2E-51,"d":"2.00E-51"},"translocase of inner mitochondrial membrane 8A2 [Rattus norvegicus]","gi|157821784|ref|NM_001109429.1|",533,0,"Rattus norvegicus translocase of inner mitochondrial membrane 8A2 (Timm8a2), mRNA","Q4FZG7",160,{"v":5e-47,"d":"5.00E-47"},"Putative mitochondrial import inner membrane translocase subunit Tim8 A-B",".",".",".",".","pfam02953","zf-Tim10_DDP","Tim10/DDP family zinc finger. Putative zinc binding domain with four conserved cysteine residues. This domain is found in the human disease protein TIMM8A. Members of this family such as Tim9 and Tim10 are involved in mitochondrial protein import. Members of this family seem to be localized to the mitochondrial intermembrane space.","GO:0008150|biological_process;GO:0015031|protein transport;","GO:0005575|cellular_component;GO:0005743|mitochondrial inner membrane;GO:0005758|mitochondrial intermembrane space;","GO:0003674|molecular_function;GO:0046872|metal ion binding;","K17780","TIM8; mitochondrial import inner membrane translocase subunit TIM8"]
["ENSRNOG00000018611",1,0.064330438,8,0.516494877,0.124551938,-3.005180619,0.013243279,0.006956997,"down","yes","Tpsb2","protein_coding","chr10:14382013-14383569:+","gi|149052110|gb|EDM03927.1|",1384,0,"mast cell protease 6, isoform CRA_a [Rattus norvegicus]","gi|297374766|ref|NM_019180.2|",1070,0,"Rattus norvegicus tryptase beta 2 (Tpsb2), mRNA","P50343",534,0,"Tryptase beta-2","VC1649",118,{"v":2e-28,"d":"2.00E-28"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;","GO:0005615|extracellular space;","GO:0004252|serine-type endopeptidase activity;GO:0008201|heparin binding;GO:0008233|peptidase activity;","K01340","E3.4.21.59; tryptase [EC:3.4.21.59]"]
["ENSRNOG00000055496",1,0.064330438,8,0.516494877,0.124551938,-3.005180619,0.013243279,0.006956997,"down","yes","ENSRNOG00000055496","protein_coding","chr8:20757584-20772663:-","gi|564362750|ref|XP_006242762.1|",2949,0,"PREDICTED: zinc finger protein OZF-like [Rattus norvegicus]","gi|672061169|ref|XM_006242700.2|",2378,0,"PREDICTED: Rattus norvegicus zinc finger protein OZF-like (LOC103690166), transcript variant X2, mRNA","P17030",403,{"v":2e-130,"d":"2.00E-130"},"Zinc finger protein 25",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".","GO:0046872|metal ion binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSRNOG00000063544",1,0.064330438,8,0.516494877,0.124551938,-3.005180619,0.013243279,0.006956997,"down","yes","ENSRNOG00000063544","lncRNA","chr7:27813954-27818526:-",".",".",".",".","gi|73853582|gb|AC161054.3|",645,0,"Mus musculus BAC clone RP23-381H23 from chromosome 10, complete sequence",".",".",".",".",".",".",".",".","pfam07191","zinc-ribbons_6","zinc-ribbons. This family consists of several short, hypothetical bacterial proteins of around 70 residues in length. Members of this family have 8 highly conserved cysteine residues, which form two zinc ribbon domains.",".",".",".",".","."]
["ENSRNOG00000065655",1,0.064330438,8,0.516494877,0.124551938,-3.005180619,0.013243279,0.006956997,"down","yes","ENSRNOG00000065655","protein_coding","chr3:159654904-159657981:-","gi|672059154|ref|XP_008763709.1|",3129,0,"PREDICTED: MLV-related proviral Env polyprotein-like [Rattus norvegicus]","gi|672081238|ref|XM_008771515.1|",1926,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102556474 (LOC102556474), mRNA","P21415",478,{"v":1e-157,"d":"1.00E-157"},"Envelope glycoprotein",".",".",".",".","pfam00429","TLV_coat","ENV polyprotein (coat polyprotein).",".",".",".",".","."]
["ENSRNOG00000066578",1,0.064330438,8,0.516494877,0.124551938,-3.005180619,0.013243279,0.006956997,"down","yes","ENSRNOG00000066578","lncRNA","chr15:18211264-18216896:+",".",".",".",".","gi|672077675|ref|XM_006251786.2|",167,{"v":2e-80,"d":"2.00E-80"},"PREDICTED: Rattus norvegicus prostaglandin E receptor 2 (subtype EP2) (Ptger2), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam11842","DUF3362","Domain of unknown function (DUF3362). This domain is functionally uncharacterized. This domain is found in bacteria and archaea. This presumed domain is typically between 117 to 158 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000057127",8,0.514643505,21,1.355799053,0.37958686,-1.397498042,0.013663902,0.0071537,"down","yes","Zg16b","protein_coding","chr10:12979020-12983572:-","gi|672066959|ref|XP_008765811.1|",859,{"v":2e-111,"d":"2.00E-111"},"PREDICTED: uncharacterized protein LOC363551 isoform X1 [Rattus norvegicus]","gi|672066958|ref|XM_008767589.1|",1049,0,"PREDICTED: Rattus norvegicus similar to Prostatic spermine-binding protein precursor (SBP) (RGD1562673), transcript variant X1, mRNA","P08723",219,{"v":3e-67,"d":"3.00E-67"},"Prostatic spermine-binding protein",".",".",".",".","pfam01419","Jacalin","Jacalin-like lectin domain. Proteins containing this domain are lectins. It is found in 1 to 6 copies in these proteins. The domain is also found in the animal prostatic spermine-binding protein.","GO:0001895|retina homeostasis;",".",".",".","."]
["ENSRNOG00000059347",8,0.514643505,21,1.355799053,0.37958686,-1.397498042,0.013663902,0.0071537,"down","yes","Rbmxl1b","protein_coding","chr4:43956281-43957944:-","gi|392347178|ref|XP_003749751.1|",917,{"v":2e-134,"d":"2.00E-134"},"PREDICTED: RNA binding motif protein, X-linked-like-1 [Rattus norvegicus]","gi|32362305|gb|AC136101.2|",1660,0,"Rattus norvegicus 4 BAC CH230-158D16 (Children's Hospital Oakland Research Institute) complete sequence","D4AE41",357,{"v":3e-116,"d":"3.00E-116"},"RNA binding motif protein, X-linked-like-1",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0006397|mRNA processing;GO:0008380|RNA splicing;GO:0048026|positive regulation of mRNA splicing, via spliceosome;","GO:0005681|spliceosomal complex;","GO:0003723|RNA binding;",".","."]
["ENSRNOG00000015408",16,1.029287011,33,2.130541369,0.483110549,-1.049574739,0.013665318,0.0071537,"down","yes","Vil1","protein_coding","chr9:75991141-76018858:+","gi|157817658|ref|NP_001101694.1|",4268,0,"villin-1 [Rattus norvegicus]","gi|197927351|ref|NM_001108224.2|",3301,0,"Rattus norvegicus villin 1 (Vil1), mRNA","Q62468",1593,0,"Villin-1",".",".",".",".","pfam00626","Gelsolin","Gelsolin repeat.","GO:0001951|intestinal D-glucose absorption;GO:0006915|apoptotic process;GO:0007173|epidermal growth factor receptor signaling pathway;GO:0008150|biological_process;GO:0008154|actin polymerization or depolymerization;GO:0008360|regulation of cell shape;GO:0009617|response to bacterium;GO:0010634|positive regulation of epithelial cell migration;GO:0030041|actin filament polymerization;GO:0030042|actin filament depolymerization;GO:0030335|positive regulation of cell migration;GO:0030836|positive regulation of actin filament depolymerization;GO:0030855|epithelial cell differentiation;GO:0032233|positive regulation of actin filament bundle assembly;GO:0032532|regulation of microvillus length;GO:0035729|cellular response to hepatocyte growth factor stimulus;GO:0040018|positive regulation of multicellular organism growth;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045010|actin nucleation;GO:0051014|actin filament severing;GO:0051016|barbed-end actin filament capping;GO:0051125|regulation of actin nucleation;GO:0051693|actin filament capping;GO:0060327|cytoplasmic actin-based contraction involved in cell motility;GO:0061041|regulation of wound healing;GO:0071364|cellular response to epidermal growth factor stimulus;GO:1902896|terminal web assembly;GO:1903078|positive regulation of protein localization to plasma membrane;GO:2000392|regulation of lamellipodium morphogenesis;GO:2000394|positive regulation of lamellipodium morphogenesis;","GO:0001726|ruffle;GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005902|microvillus;GO:0005903|brush border;GO:0015629|actin cytoskeleton;GO:0030027|lamellipodium;GO:0030175|filopodium;GO:0032432|actin filament bundle;GO:0032433|filopodium tip;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0035727|lysophosphatidic acid binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0043027|cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0051015|actin filament binding;","K05761","VIL1; villin 1"]
["ENSRNOG00000010649",12,0.771965258,27,1.743170211,0.442851337,-1.175105621,0.014542876,0.007579747,"down","yes","Ctnnd2","protein_coding","chr2:81167117-82015764:+","gi|407728599|ref|NP_001258431.1|",6013,0,"catenin delta-2 [Rattus norvegicus]","gi|407728598|ref|NM_001271502.1|",4653,0,"Rattus norvegicus catenin delta 2 (Ctnnd2), mRNA","O35927",2315,0,"Catenin delta-2",".",".",".",".","pfam00514","Arm","Armadillo/beta-catenin-like repeat. Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.","GO:0001763|morphogenesis of a branching structure;GO:0007043|cell-cell junction assembly;GO:0007612|learning;GO:0048167|regulation of synaptic plasticity;GO:0050808|synapse organization;GO:0060828|regulation of canonical Wnt signaling pathway;GO:0060997|dendritic spine morphogenesis;GO:0098609|cell-cell adhesion;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005912|adherens junction;GO:0014069|postsynaptic density;GO:0030054|cell junction;GO:0030425|dendrite;GO:0043005|neuron projection;GO:0043204|perikaryon;","GO:0005515|protein binding;GO:0008013|beta-catenin binding;GO:0045296|cadherin binding;","K23491","CTNND2; catenin delta-2"]
["ENSRNOG00000047004",4,0.257321753,14,0.903866035,0.284690145,-1.812535541,0.015089925,0.007846966,"down","yes","ENSRNOG00000047004","protein_coding","chr3:117603564-117607125:+","gi|795650196|ref|XP_011739634.1|",498,{"v":9e-54,"d":"9.00E-54"},"PREDICTED: transmembrane protein 239 isoform X1 [Macaca nemestrina]","gi|672017345|ref|XM_006224613.2|",1323,0,"PREDICTED: Rattus norvegicus transmembrane protein 239 (Tmem239), transcript variant X1, mRNA","Q9DA47",157,{"v":4e-42,"d":"4.00E-42"},"Transmembrane protein 239",".",".",".",".","pfam03420","Peptidase_U9","Prohead core protein protease.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000050670",4,0.257321753,14,0.903866035,0.284690145,-1.812535541,0.015089925,0.007846966,"down","yes","L1td1","protein_coding","chr5:113379870-113385730:+","gi|880903732|ref|XP_012971938.1|",2555,0,"PREDICTED: LINE-1 type transposase domain-containing protein 1 [Mesocricetus auratus]","gi|124487094|ref|NM_001081202.1|",1299,0,"Mus musculus LINE-1 type transposase domain containing 1 (L1td1), mRNA","Q587J6",615,0,"LINE-1 type transposase domain-containing protein 1",".",".",".",".","pfam02994","Transposase_22","L1 transposable element.",".","GO:0043231|intracellular membrane-bounded organelle;",".",".","."]
["ENSRNOG00000009466",2,0.128660876,10,0.645618597,0.199283102,-2.327108714,0.01586341,0.008211061,"down","yes","Unc45b","protein_coding","chr10:67845462-67873389:+","gi|148683737|gb|EDL15684.1|",4106,0,"unc-45 homolog B (C. elegans) [Mus musculus]","gi|157820136|ref|NM_001107028.1|",3384,0,"Rattus norvegicus unc-45 myosin chaperone B (Unc45b), mRNA","Q8CGY6",1169,0,"Protein unc-45 homolog B",".",".",".",".","pfam11701","UNC45-central","Myosin-binding striated muscle assembly central. The UNC-45 or small muscle protein 1 of C.elegans is expressed in two forms from different genomic positions in mammals, as a general tissue protein UNC-45a and a specific form Unc-45b expressed only in striated and skeletal muscle. All members carry up to three amino-terminal tetratricopeptide repeat (TPR) domains towards their N-terminal, a UCS domain at the C-terminal that contains a number of Arm repeats pfam00514 and this central region of approximately 400 residues. Both the general form and the muscle form of UNC-45 function in myotube formation through cell fusion. Myofibril formation requires both GC and SM UNC-45, consistent with the fact that the cytoskeleton is necessary for the development and maintenance of organized myofibrils. The S. pombe Rng3p, is crucial for cell shape, normal actin cytoskeleton, and contractile ring assembly, and is essential for assembly of the myosin II-containing progenitors of the contractile ring. Widespread defects in the cytoskeleton are found in null mutants of all three fungal proteins. Mammalian Unc45 is found to act as a specific chaperone during the folding of myosin and the assembly of striated muscle by forming a stable complex with the general chaperone Hsp90. The exact function of this central region is not known.","GO:0007517|muscle organ development;GO:0030154|cell differentiation;GO:0061077|chaperone-mediated protein folding;","GO:0005829|cytosol;","GO:0051879|Hsp90 protein binding;","K21991","UNC45; protein unc-45"]
["ENSRNOG00000015526",2,0.128660876,10,0.645618597,0.199283102,-2.327108714,0.01586341,0.008211061,"down","yes","Rhcg","protein_coding","chr1:133531716-133555876:-","gi|149057263|gb|EDM08586.1|",2358,0,"Rhesus blood group-associated C glycoprotein [Rattus norvegicus]","gi|34013519|ref|NM_183053.1|",1930,0,"Rattus norvegicus Rh family, C glycoprotein (Rhcg), mRNA","Q7TNN9",862,0,"Ammonium transporter Rh type C",".",".",".",".","pfam00909","Ammonium_transp","Ammonium Transporter Family.","GO:0006873|cellular ion homeostasis;GO:0006885|regulation of pH;GO:0008150|biological_process;GO:0015696|ammonium transport;GO:0070634|transepithelial ammonium transport;GO:0072488|ammonium transmembrane transport;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009925|basal plasma membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0031410|cytoplasmic vesicle;","GO:0003674|molecular_function;GO:0008519|ammonium transmembrane transporter activity;GO:0030506|ankyrin binding;GO:0042802|identical protein binding;","K06580","SLC42A, RHAG, RHBG, RHCG, CD241; ammonium transporter Rh"]
["ENSRNOG00000063072",2,0.128660876,10,0.645618597,0.199283102,-2.327108714,0.01586341,0.008211061,"down","yes","Lcn3","protein_coding","chr3:8539737-8544201:-","gi|672016516|ref|XP_008773527.1|",969,{"v":4e-124,"d":"4.00E-124"},"PREDICTED: lipocalin-1 [Rattus norvegicus]","gi|672016515|ref|XM_008775305.1|",569,0,"PREDICTED: Rattus norvegicus lipocalin 3 (Lcn3), mRNA","Q62471",255,{"v":1E-78,"d":"1.00E-78"},"Vomeronasal secretory protein 1",".",".",".",".","pfam00061","Lipocalin","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.",".",".",".",".","."]
["ENSRNOG00000000858",3,0.192991315,12,0.774742316,0.249103877,-2.005180619,0.01606857,0.008311981,"down","yes","Sapcd1","protein_coding","chr20:3793967-3795790:+","gi|60678288|ref|NP_001004069.1|",690,{"v":5e-88,"d":"5.00E-88"},"suppressor APC domain-containing protein 1 [Rattus norvegicus]","gi|260099638|ref|NM_001004069.2|",852,0,"Rattus norvegicus suppressor APC domain containing 1 (Sapcd1), mRNA",".",".",".",".",".",".",".",".","pfam11414","Suppressor_APC","Adenomatous polyposis coli tumor suppressor protein. The tumor suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.",".",".",".",".","."]
["ENSRNOG00000058944",3,0.192991315,12,0.774742316,0.249103877,-2.005180619,0.01606857,0.008311981,"down","yes","SNORA71","snoRNA","chr3:147017736-147017867:-",".",".",".",".","gi|908663385|tpe|LN872584.1|",114,{"v":1E-51,"d":"1.00E-51"},"TPA: Mus musculus SNORA71 (U71b) gene for small nucleolar RNA SNORA71 (U71b)",".",".",".",".",".",".",".",".","pfam11756","YgbA_NO","Nitrous oxide-stimulated promoter. The function of ygaB is not known but it is a promoter that is stimulated by the presence of nitrous oxide. It is regulated by the gene-product of the bacterial nsrR gene.",".",".",".",".","."]
["ENSRNOG00000069116",3,0.192991315,12,0.774742316,0.249103877,-2.005180619,0.01606857,0.008311981,"down","yes","ENSRNOG00000069116","lncRNA","chr17:42241130-42242401:+","gi|641723013|ref|XP_008151309.1|",132,2e-06,"PREDICTED: serine/threonine-protein kinase Kist [Eptesicus fuscus]","gi|8393667|ref|NM_017293.1|",1250,0,"Rattus norvegicus U2AF homology motif (UHM) kinase 1 (Uhmk1), mRNA","Q63285",56.2,3e-07,"Serine/threonine-protein kinase Kist",".",".",".",".","pfam03117","Herpes_UL49_1","UL49 family. Members of this family, found in several herpesviruses, include EBV BFRF2 and other UL49 proteins (e.g. HCMVA UL49, HSV6 U33). There are eight conserved cysteine residues in this alignment, all lying towards the C-terminus. Their function is unknown.",".",".",".",".","."]
["ENSRNOG00000037688",13,0.836295696,28,1.80773207,0.462621486,-1.112095823,0.017273617,0.00887185,"down","yes","Ak9","protein_coding","chr20:44724496-44941136:+","gi|672031948|ref|XP_008773227.1|",6208,0,"PREDICTED: adenylate kinase 9 isoform X3, partial [Rattus norvegicus]","gi|672086760|ref|XM_008773020.1|",6196,0,"PREDICTED: Rattus norvegicus similar to novel protein (RGD1560386), transcript variant X5, mRNA","Q5TCS8",1544,0,"Adenylate kinase 9","CAC3112",71.2,{"v":3e-12,"d":"3.00E-12"},"COG0563","pfam00406","ADK","Adenylate kinase.","GO:0006174|dADP phosphorylation;GO:0006186|dGDP phosphorylation;GO:0006756|AMP phosphorylation;GO:0006757|ATP generation from ADP;GO:0061508|CDP phosphorylation;GO:0061565|dAMP phosphorylation;GO:0061566|CMP phosphorylation;GO:0061567|dCMP phosphorylation;GO:0061568|GDP phosphorylation;GO:0061569|UDP phosphorylation;GO:0061570|dCDP phosphorylation;GO:0061571|TDP phosphorylation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0031965|nuclear membrane;","GO:0004017|adenylate kinase activity;GO:0004550|nucleoside diphosphate kinase activity;GO:0005524|ATP binding;GO:0050145|nucleoside monophosphate kinase activity;","K18533","AK9; adenylate/nucleoside-diphosphate kinase [EC:2.7.4.3 2.7.4.6]"]
["ENSRNOG00000017223",9,0.578973944,22,1.420360912,0.407624526,-1.294687237,0.017295853,0.008881673,"down","yes","Plg","protein_coding","chr1:48325185-48367786:-","gi|16758216|ref|NP_445943.1|",4152,0,"plasminogen precursor [Rattus norvegicus]","gi|298881889|emb|FQ210878.1|",2821,0,"Rattus norvegicus TL0ABA20YL13 mRNA sequence","Q01177",1606,0,"Plasminogen","VC1649",110,{"v":2e-24,"d":"2.00E-24"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;GO:0007596|blood coagulation;GO:0010812|negative regulation of cell-substrate adhesion;GO:0022617|extracellular matrix disassembly;GO:0042246|tissue regeneration;GO:0042730|fibrinolysis;GO:0043536|positive regulation of blood vessel endothelial cell migration;GO:0045445|myoblast differentiation;GO:0046716|muscle cell cellular homeostasis;GO:0048771|tissue remodeling;GO:0051603|proteolysis involved in cellular protein catabolic process;GO:0051702|interaction with symbiont;GO:0051918|negative regulation of fibrinolysis;GO:0051919|positive regulation of fibrinolysis;GO:0060707|trophoblast giant cell differentiation;GO:0060716|labyrinthine layer blood vessel development;GO:0071674|mononuclear cell migration;GO:0099183|trans-synaptic signaling by BDNF, modulating synaptic transmission;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0019897|extrinsic component of plasma membrane;GO:0031232|extrinsic component of external side of plasma membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098978|glutamatergic synapse;","GO:0004175|endopeptidase activity;GO:0004252|serine-type endopeptidase activity;GO:0005102|signaling receptor binding;GO:0019899|enzyme binding;GO:0019900|kinase binding;GO:0019904|protein domain specific binding;GO:0034185|apolipoprotein binding;GO:0051087|chaperone binding;GO:1990405|protein antigen binding;","K01315","PLG; plasminogen [EC:3.4.21.7]"]
["ENSRNOG00000005246",6,0.385982629,17,1.097551614,0.351676062,-1.50768096,0.018854706,0.009641424,"down","yes","Tfap2c","protein_coding","chr3:161315031-161322995:+","gi|564344758|ref|XP_006235753.1|",2296,0,"PREDICTED: transcription factor AP-2 gamma isoform X1 [Rattus norvegicus]","gi|672048157|ref|XM_006235691.2|",1751,0,"PREDICTED: Rattus norvegicus transcription factor AP-2 gamma (Tfap2c), transcript variant X1, mRNA","Q61312",764,0,"Transcription factor AP-2 gamma",".",".",".",".","pfam03299","TF_AP-2","Transcription factor AP-2.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001829|trophectodermal cell differentiation;GO:0001942|hair follicle development;GO:0003334|keratinocyte development;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008150|biological_process;GO:0008584|male gonad development;GO:0019827|stem cell population maintenance;GO:0021877|forebrain neuron fate commitment;GO:0021987|cerebral cortex development;GO:0030154|cell differentiation;GO:0030718|germ-line stem cell population maintenance;GO:0035019|somatic stem cell population maintenance;GO:0040029|regulation of gene expression, epigenetic;GO:0042127|regulation of cell proliferation;GO:0043588|skin development;GO:0045682|regulation of epidermis development;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048733|sebaceous gland development;GO:0048856|anatomical structure development;GO:0060598|dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis;GO:0060750|epithelial cell proliferation involved in mammary gland duct elongation;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005739|mitochondrion;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:1990837|sequence-specific double-stranded DNA binding;","K09177","TFAP2C; transcription factor AP-2 gamma"]
["ENSRNOG00000053337",6,0.385982629,17,1.097551614,0.351676062,-1.50768096,0.018854706,0.009641424,"down","yes","Ly49s6","protein_coding","chr4:163884837-164104899:-","gi|56789198|gb|AAH88257.1|",745,{"v":7e-93,"d":"7.00E-93"},"Ly49s6 protein [Rattus norvegicus]","gi|56789197|gb|BC088257.1|",1702,0,"Rattus norvegicus Ly49 stimulatory receptor 6, mRNA (cDNA clone MGC:109079 IMAGE:7375677), complete cds","Q60682",139,{"v":5E-36,"d":"5.00E-36"},"Killer cell lectin-like receptor 8",".",".",".",".","pfam08391","Ly49","Ly49-like protein, N-terminal region. The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000034093",14,0.900626135,29,1.87229393,0.481028176,-1.055806692,0.020185531,0.010288783,"down","yes","AABR07011951.1","protein_coding","chr2:164044261-164046336:+","gi|676282501|gb|KFO35963.1|",3008,0,"Heat shock cognate 71 kDa protein [Fukomys damarensis]","gi|149879639|ref|NG_004796.2|",2032,0,"Rattus norvegicus heat shock cognate protein 70, pseudogene 1 (Hsc70-ps1) on chromosome 2","P63018",1152,0,"Heat shock cognate 71 kDa protein",".",".",".",".","pfam00012","HSP70","Hsp70 protein. Hsp70 chaperones help to fold many proteins. Hsp70 assisted folding involves repeated cycles of substrate binding and release. Hsp70 activity is ATP dependent. Hsp70 proteins are made up of two regions: the amino terminus is the ATPase domain and the carboxyl terminus is the substrate binding region.","GO:0072318|clathrin coat disassembly;",".",".",".","."]
["ENSRNOG00000006360",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","Reg3a","protein_coding","chr4:110872425-110875157:+","gi|224994175|ref|NP_001139318.1|",934,{"v":1e-124,"d":"1.00E-124"},"regenerating islet-derived protein 3-alpha precursor [Rattus norvegicus]","gi|225903410|ref|NM_172077.2|",890,0,"Rattus norvegicus regenerating islet-derived 3 alpha (Reg3a), transcript variant 1, mRNA","P35231",360,{"v":2e-124,"d":"2.00E-124"},"Regenerating islet-derived protein 3-alpha",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0006953|acute-phase response;GO:0008284|positive regulation of cell proliferation;GO:0010838|positive regulation of keratinocyte proliferation;GO:0043434|response to peptide hormone;GO:0044278|cell wall disruption in other organism;GO:0045617|negative regulation of keratinocyte differentiation;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0090303|positive regulation of wound healing;","GO:0005615|extracellular space;","GO:0030246|carbohydrate binding;GO:0038023|signaling receptor activity;GO:0042834|peptidoglycan binding;GO:0070492|oligosaccharide binding;",".","."]
["ENSRNOG00000008838",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","Gkn1","protein_coding","chr4:119790101-119795389:-","gi|39725719|ref|NP_945323.1|",914,{"v":2e-122,"d":"2.00E-122"},"gastrokine-1 precursor [Rattus norvegicus]","gi|39725718|ref|NM_198972.1|",706,0,"Rattus norvegicus gastrokine 1 (Gkn1), mRNA","Q9CR36",332,{"v":3e-114,"d":"3.00E-114"},"Gastrokine-1",".",".",".",".","pfam04089","BRICHOS","BRICHOS domain. The BRICHOS domain is about 100 amino acids long. It is found in a variety of proteins implicated in dementia, respiratory distress and cancer. Its exact function is unknown; roles that have been proposed for it include (a) in targeting of the protein to the secretory pathway, (b) intramolecular chaperone-like function, and (c) assisting the specialized intracellular protease processing system. This C-terminal domain is embedded in the endoplasmic reticulum lumen, and binds to the N-terminal, transmembrane, SP_C, pfam08999, provided that it is in non-helical conformation. Thus the Brichos domain of proSP-C is a chaperone that induces alpha-helix formation of an aggregation-prone TM region.","GO:0007165|signal transduction;GO:0008284|positive regulation of cell proliferation;GO:0042127|regulation of cell proliferation;","GO:0005615|extracellular space;GO:0030141|secretory granule;","GO:0008083|growth factor activity;","K25538","GKN1; gastrokine-1"]
["ENSRNOG00000011174",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","Fpr1","protein_coding","chr1:58747246-58756559:-","gi|157819173|ref|NP_001099686.1|",1867,0,"fMet-Leu-Phe receptor [Rattus norvegicus]","gi|672034402|ref|XM_006227988.2|",1456,0,"PREDICTED: Rattus norvegicus formyl peptide receptor 1 (Fpr1), transcript variant X1, mRNA","P33766",632,0,"fMet-Leu-Phe receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0002430|complement receptor mediated signaling pathway;GO:0006954|inflammatory response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0001664|G protein-coupled receptor binding;GO:0004875|complement receptor activity;GO:0004930|G protein-coupled receptor activity;GO:0004982|N-formyl peptide receptor activity;GO:0005124|scavenger receptor binding;GO:0050786|RAGE receptor binding;","K04172","FPR1; formyl peptide receptor 1"]
["ENSRNOG00000015744",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","Spata25","protein_coding","chr3:153562528-153564480:-","gi|71043742|ref|NP_001020940.1|",876,{"v":1e-111,"d":"1.00E-111"},"spermatogenesis-associated protein 25 [Rattus norvegicus]","gi|71043741|ref|NM_001025769.1|",1583,0,"Rattus norvegicus spermatogenesis associated 25 (Spata25), mRNA","Q9DA57",315,{"v":6E-103,"d":"6.00E-103"},"Spermatogenesis-associated protein 25",".",".",".",".","pfam15218","SPATA25","Spermatogenesis-associated protein 25. This family of proteins may be involved in spermatogenesis.","GO:0007283|spermatogenesis;",".",".",".","."]
["ENSRNOG00000016685",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","Mc5r","protein_coding","chr18:61915188-61920229:+","gi|158533997|ref|NP_038624.2|",1761,0,"melanocortin receptor 5 [Mus musculus]","gi|298897091|emb|FQ224332.1|",3763,0,"Rattus norvegicus TL0ACA6YD02 mRNA sequence","P35345",643,0,"Melanocortin receptor 5",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0019222|regulation of metabolic process;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004977|melanocortin receptor activity;GO:0042562|hormone binding;","K04203","MC5R; melanocortin 5 receptor"]
["ENSRNOG00000020077",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","Fam170b","protein_coding","chr16:8101914-8104705:+","gi|564318559|ref|XP_006222176.1|",1229,{"v":4e-162,"d":"4.00E-162"},"PREDICTED: putative protein FAM170B [Rattus norvegicus]","gi|672029060|ref|XM_006222114.2|",1667,0,"PREDICTED: Rattus norvegicus family with sequence similarity 170, member B (Fam170b), transcript variant X1, mRNA","E9PXT9",437,{"v":1e-147,"d":"1.00E-147"},"Protein FAM170B",".",".",".",".","pfam12756","zf-C2H2_2","C2H2 type zinc-finger (2 copies). This family contains two copies of a C2H2-like zinc finger domain.","GO:0009566|fertilization;GO:0080154|regulation of fertilization;GO:2000344|positive regulation of acrosome reaction;","GO:0001669|acrosomal vesicle;GO:0002081|outer acrosomal membrane;",".",".","."]
["ENSRNOG00000020251",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","Art1","protein_coding","chr1:156482621-156487172:+","gi|157820191|ref|NP_001101011.1|",1465,0,"GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 precursor [Rattus norvegicus]","gi|158631182|ref|NM_001107541.2|",1369,0,"Rattus norvegicus ADP-ribosyltransferase 1 (Art1), mRNA","Q60935",549,0,"GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1",".",".",".",".","pfam01129","ART","NAD:arginine ADP-ribosyltransferase.","GO:0006471|protein ADP-ribosylation;GO:0018120|peptidyl-arginine ADP-ribosylation;","GO:0009986|cell surface;GO:0031225|anchored component of membrane;","GO:0003950|NAD+ ADP-ribosyltransferase activity;","K06716","ART1, CD296; ADP-ribosyltransferase 1 [EC:2.4.2.31]"]
["ENSRNOG00000022777",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","Six1","protein_coding","chr6:91746739-91751975:-","gi|148704568|gb|EDL36515.1|",1414,0,"sine oculis-related homeobox 1 homolog (Drosophila), partial [Mus musculus]","gi|209954659|ref|NM_053759.1|",3188,0,"Rattus norvegicus SIX homeobox 1 (Six1), mRNA","Q62231",525,{"v":4e-177,"d":"4.00E-177"},"Homeobox protein SIX1",".",".",".",".","pfam05920","Homeobox_KN","Homeobox KN domain. This is a homeobox transcription factor KN domain conserved from fungi to human and plants.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001657|ureteric bud development;GO:0001658|branching involved in ureteric bud morphogenesis;GO:0001759|organ induction;GO:0001822|kidney development;GO:0003151|outflow tract morphogenesis;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006915|apoptotic process;GO:0007219|Notch signaling pathway;GO:0007382|specification of segmental identity, maxillary segment;GO:0007389|pattern specification process;GO:0007519|skeletal muscle tissue development;GO:0007605|sensory perception of sound;GO:0008582|regulation of synaptic growth at neuromuscular junction;GO:0010467|gene expression;GO:0010468|regulation of gene expression;GO:0014033|neural crest cell differentiation;GO:0014842|regulation of skeletal muscle satellite cell proliferation;GO:0014857|regulation of skeletal muscle cell proliferation;GO:0021610|facial nerve morphogenesis;GO:0022008|neurogenesis;GO:0030855|epithelial cell differentiation;GO:0030878|thyroid gland development;GO:0030910|olfactory placode formation;GO:0032880|regulation of protein localization;GO:0034504|protein localization to nucleus;GO:0035909|aorta morphogenesis;GO:0042472|inner ear morphogenesis;GO:0042474|middle ear morphogenesis;GO:0043066|negative regulation of apoptotic process;GO:0043524|negative regulation of neuron apoptotic process;GO:0043586|tongue development;GO:0045664|regulation of neuron differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048538|thymus development;GO:0048665|neuron fate specification;GO:0048699|generation of neurons;GO:0048701|embryonic cranial skeleton morphogenesis;GO:0048704|embryonic skeletal system morphogenesis;GO:0048705|skeletal system morphogenesis;GO:0048741|skeletal muscle fiber development;GO:0048839|inner ear development;GO:0048856|anatomical structure development;GO:0050678|regulation of epithelial cell proliferation;GO:0051451|myoblast migration;GO:0060037|pharyngeal system development;GO:0061055|myotome development;GO:0061197|fungiform papilla morphogenesis;GO:0061551|trigeminal ganglion development;GO:0071599|otic vesicle development;GO:0072075|metanephric mesenchyme development;GO:0072095|regulation of branch elongation involved in ureteric bud branching;GO:0072107|positive regulation of ureteric bud formation;GO:0072172|mesonephric tubule formation;GO:0072193|ureter smooth muscle cell differentiation;GO:0072513|positive regulation of secondary heart field cardioblast proliferation;GO:0086100|endothelin receptor signaling pathway;GO:0090103|cochlea morphogenesis;GO:0090190|positive regulation of branching involved in ureteric bud morphogenesis;GO:0090336|positive regulation of brown fat cell differentiation;GO:1905243|cellular response to 3,3',5-triiodo-L-thyronine;GO:2000729|positive regulation of mesenchymal cell proliferation involved in ureter development;GO:2001014|regulation of skeletal muscle cell differentiation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005730|nucleolus;GO:0005737|cytoplasm;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001223|transcription coactivator binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003700|DNA-binding transcription factor activity;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K15614","SIX1; homeobox protein SIX1"]
["ENSRNOG00000024882",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","Pax1","protein_coding","chr3:134789182-134801636:+","gi|672047283|ref|XP_006235214.2|",2064,0,"PREDICTED: paired box protein Pax-1 isoform X1 [Rattus norvegicus]","gi|672047282|ref|XM_006235152.2|",2732,0,"PREDICTED: Rattus norvegicus paired box 1 (Pax1), transcript variant X1, mRNA","P09084",699,0,"Paired box protein Pax-1",".",".",".",".","pfam00292","PAX","'Paired box' domain.","GO:0001501|skeletal system development;GO:0001756|somitogenesis;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007389|pattern specification process;GO:0008283|cell proliferation;GO:0043367|CD4-positive, alpha-beta T cell differentiation;GO:0043374|CD8-positive, alpha-beta T cell differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048538|thymus development;GO:0048856|anatomical structure development;GO:0060017|parathyroid gland development;GO:0060349|bone morphogenesis;GO:0061056|sclerotome development;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837|sequence-specific double-stranded DNA binding;","K09382","PAX1_9; paired box protein 1/9"]
["ENSRNOG00000032554",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","Scd4","protein_coding","chr1:243203881-243215148:+","gi|564299269|ref|XP_001057317.4|",1909,0,"PREDICTED: acyl-CoA desaturase 1 [Rattus norvegicus]","gi|672040629|ref|XM_574671.6|",1062,0,"PREDICTED: Rattus norvegicus stearoyl-coenzyme A desaturase 4 (Scd4), mRNA","Q6T707",672,0,"Acyl-CoA desaturase 4","SPCC1281.06c_1",193,{"v":1E-56,"d":"1.00E-56"},"COG1398","pfam00487","FA_desaturase","Fatty acid desaturase.","GO:0006633|fatty acid biosynthetic process;GO:0006636|unsaturated fatty acid biosynthetic process;GO:0031670|cellular response to nutrient;GO:0070542|response to fatty acid;GO:1903966|monounsaturated fatty acid biosynthetic process;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0030176|integral component of endoplasmic reticulum membrane;","GO:0004768|stearoyl-CoA 9-desaturase activity;GO:0005506|iron ion binding;GO:0032896|palmitoyl-CoA 9-desaturase activity;","K00507","SCD, desC; stearoyl-CoA desaturase (Delta-9 desaturase) [EC:1.14.19.1]"]
["ENSRNOG00000035595",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","Mir429","miRNA","chr5:166647459-166647543:-",".",".",".",".","gi|921274083|ref|NR_132445.1|",85,{"v":9e-36,"d":"9.00E-36"},"Rattus norvegicus uncharacterized LOC106182250 (LOC106182250), long non-coding RNA",".",".",".",".",".",".",".",".","pfam05686","Glyco_transf_90","Glycosyl transferase family 90. This family of glycosyl transferases are specifically (mannosyl) glucuronoxylomannan/galactoxylomannan -beta 1,2-xylosyltransferases, EC:2.4.2.-.","GO:0007605|sensory perception of sound;GO:0071230|cellular response to amino acid stimulus;",".",".","K17019","MIR429; microRNA 429"]
["ENSRNOG00000037374",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","Ly6al","protein_coding","chr7:107183469-107189981:-","gi|189339280|ref|NP_001121571.1|",696,{"v":6e-88,"d":"6.00E-88"},"lymphocyte antigen 6 complex, locus A-like precursor [Rattus norvegicus]","gi|189339279|ref|NM_001128099.1|",798,0,"Rattus norvegicus lymphocyte antigen 6 complex, locus A-like (Ly6al), mRNA","Q63317",207,{"v":6e-64,"d":"6.00E-64"},"Lymphocyte antigen 6B",".",".",".",".","pfam00021","UPAR_LY6","u-PAR/Ly-6 domain. This extracellular disulphide bond rich domain is related to pfam00087.",".",".",".","K06846","LY6D_E_F_G6_H; lymphocyte antigen 6 complex locus protein D/E/F/G6/H"]
["ENSRNOG00000037894",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","AABR07068042.1","protein_coding","chr9:73264478-73268630:+","gi|74179767|dbj|BAE22508.1|",357,{"v":1e-40,"d":"1.00E-40"},"unnamed protein product [Mus musculus]","gi|644986914|tpe|HG977898.1|",207,{"v":9E-103,"d":"9.00E-103"},"TPA: Mus musculus long non-coding RNA OTTMUST00000052539.2 (Apol7d gene), antisense",".",".",".",".",".",".",".",".","pfam04735","Baculo_helicase","Baculovirus DNA helicase.",".",".",".",".","."]
["ENSRNOG00000039152",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","Frem3","protein_coding","chr19:27308469-27366771:-","gi|300794644|ref|NP_001178628.1|",10965,0,"FRAS1-related extracellular matrix protein 3 precursor [Rattus norvegicus]","gi|300794643|ref|NM_001191699.1|",6595,0,"Rattus norvegicus FRAS1 related extracellular matrix 3 (Frem3), mRNA","Q5H8B9",3507,0,"FRAS1-related extracellular matrix protein 3",".",".",".",".","pfam03160","Calx-beta","Calx-beta domain.","GO:0007154|cell communication;","GO:0005604|basement membrane;GO:0016021|integral component of membrane;",".","K23383","FREM3; FRAS1-related extracellular matrix protein 3"]
["ENSRNOG00000042330",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","Ms4a18","protein_coding","chr1:207645780-207665793:-","gi|672014884|ref|XP_008773041.1|",1516,0,"PREDICTED: membrane-spanning 4-domains subfamily A member 18 [Rattus norvegicus]","gi|672014883|ref|XM_008774819.1|",829,0,"PREDICTED: Rattus norvegicus membrane-spanning 4-domains, subfamily A, member 18 (Ms4a18), mRNA","Q3C1V0",271,{"v":2e-86,"d":"2.00E-86"},"Membrane-spanning 4-domains subfamily A member 18",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.",".","GO:0016021|integral component of membrane;",".","K22190","MS4A3S; membrane-spanning 4-domains subfamily A member 3/4/8/12/15/18"]
["ENSRNOG00000053055",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","Otop3","protein_coding","chr10:100577392-100588726:+","gi|148702528|gb|EDL34475.1|",2650,0,"otopetrin 3, isoform CRA_a, partial [Mus musculus]","gi|157786881|ref|NM_001105852.1|",2301,0,"Rattus norvegicus otopetrin 3 (Otop3), mRNA","Q80UF9",971,0,"Proton channel OTOP3",".",".",".",".","pfam03189","Otopetrin","Otopetrin.","GO:1902600|proton transmembrane transport;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0015252|proton channel activity;",".","."]
["ENSRNOG00000056400",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","Hhipl2","protein_coding","chr13:95054694-95074608:+","gi|109498329|ref|XP_229754.4|",3748,0,"PREDICTED: HHIP-like protein 2 [Rattus norvegicus]","gi|672027470|ref|XM_001064362.4|",2151,0,"PREDICTED: Rattus norvegicus hedgehog interacting protein-like 2 (Hhipl2), mRNA","Q9D2G9",1332,0,"HHIP-like protein 2","slr1608",103,{"v":2e-22,"d":"2.00E-22"},"COG2133","pfam07995","GSDH","Glucose / Sorbosone dehydrogenase. Members of this family are glucose/sorbosone dehydrogenases that possess a beta-propeller fold.",".",".","GO:0003824|catalytic activity;","K25557","HHIPL; HHIP-like protein"]
["ENSRNOG00000058286",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","ENSRNOG00000058286","protein_coding","chr1:63149437-63179628:+","gi|564296609|ref|XP_001061453.3|",4388,0,"PREDICTED: vomeronasal type-2 receptor 116-like [Rattus norvegicus]","gi|564296608|ref|XM_001061453.3|",2574,0,"PREDICTED: Rattus norvegicus similar to putative pheromone receptor (Go-VN4) (LOC682419), mRNA","E9Q6I0",1330,0,"Vomeronasal type-2 receptor 116",".",".",".",".","pfam00003","7tm_3","7 transmembrane sweet-taste receptor of 3 GCPR. This is a domain of seven transmembrane regions that forms the C-terminus of some subclass 3 G-coupled-protein receptors. It is often associated with a downstream cysteine-rich linker domain, NCD3G pfam07562, which is the human sweet-taste receptor, and the N-terminal domain, ANF_receptor pfam01094. The seven TM regions assemble in such a way as to produce a docking pocket into which such molecules as cyclamate and lactisole have been found to bind and consequently confer the taste of sweetness.","GO:0007186|G protein-coupled receptor signaling pathway;","GO:0005887|integral component of plasma membrane;","GO:0004930|G protein-coupled receptor activity;","K04613","V2R; vomeronasal 2 receptor"]
["ENSRNOG00000060831",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","Clca1","protein_coding","chr2:233938677-233964369:-","gi|157818579|ref|NP_001100919.1|",4708,0,"calcium-activated chloride channel regulator 1 precursor [Rattus norvegicus]","gi|157818578|ref|NM_001107449.1|",3608,0,"Rattus norvegicus chloride channel accessory 1 (Clca1), mRNA","Q9D7Z6",1637,0,"Calcium-activated chloride channel regulator 1","sll0103",53.5,3e-06,"COG2304","pfam08434","CLCA_N","Calcium-activated chloride channel. The CLCA family of calcium-activated chloride channels has been identified in many epithelial and endothelial cell types as well as in smooth muscle cells and has four or five putative transmembrane regions. Additionally to their role as chloride channels some CLCA proteins function as adhesion molecules and may also have roles as tumor suppressors. The domain described here is found at the N-terminus of CLCAs.","GO:0006508|proteolysis;GO:0006821|chloride transport;GO:0071456|cellular response to hypoxia;","GO:0005887|integral component of plasma membrane;GO:0005902|microvillus;GO:0016021|integral component of membrane;GO:0030141|secretory granule;GO:0042589|zymogen granule membrane;","GO:0003674|molecular_function;GO:0005229|intracellular calcium activated chloride channel activity;GO:0008237|metallopeptidase activity;GO:0046872|metal ion binding;","K05027","CLCA1; calcium-activated chloride channel regulator 1"]
["ENSRNOG00000063277",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","ENSRNOG00000063277","protein_coding","chr4:102487585-102488125:+","gi|672016708|ref|XP_008773582.1|",564,{"v":3e-71,"d":"3.00E-71"},"PREDICTED: Ig kappa chain V-II region TEW-like [Rattus norvegicus]","gi|672045584|ref|XM_008761827.1|",317,{"v":6e-164,"d":"6.00E-164"},"PREDICTED: Rattus norvegicus Ig kappa chain V-II region TEW-like (LOC103691797), mRNA","P01615",125,{"v":6e-36,"d":"6.00E-36"},"Immunoglobulin kappa variable 2D-28",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000064061",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","ENSRNOG00000064061","protein_coding","chr4:98260241-98261118:+","gi|672050046|ref|XP_008761240.1|",546,{"v":4e-63,"d":"4.00E-63"},"PREDICTED: mucin-2-like [Rattus norvegicus]","gi|672050045|ref|XM_008763018.1|",278,{"v":4e-142,"d":"4.00E-142"},"PREDICTED: Rattus norvegicus mucin-2-like (LOC102552751), mRNA","A2NJV5",157,{"v":7e-48,"d":"7.00E-48"},"Immunoglobulin kappa variable 2-29",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000064207",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","ENSRNOG00000064207","protein_coding","chr6:134451511-134452137:-","gi|392341301|ref|XP_003754304.1|",630,{"v":3E-79,"d":"3.00E-79"},"PREDICTED: uncharacterized protein LOC100363765 isoform X1 [Rattus norvegicus]","gi|672021279|ref|XM_003754256.3|",325,{"v":3e-168,"d":"3.00E-168"},"PREDICTED: Rattus norvegicus hypothetical LOC100363765 (LOC100363765), transcript variant X1, mRNA","P01780",180,{"v":1E-56,"d":"1.00E-56"},"Immunoglobulin heavy variable 3-7",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000064325",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","ENSRNOG00000064325","lncRNA","chr12:32553104-32559941:-","gi|148701441|gb|EDL33388.1|",245,{"v":3e-21,"d":"3.00E-21"},"mCG1045525, partial [Mus musculus]","gi|672026716|ref|XR_590679.1|",585,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102552690 (LOC102552690), ncRNA",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSRNOG00000064511",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","Ankfn1","protein_coding","chr10:74218915-74663295:-","gi|558155754|ref|XP_006095648.1|",5312,0,"PREDICTED: ankyrin repeat and fibronectin type-III domain-containing protein 1 isoform X1 [Myotis lucifugus]","gi|672025090|ref|XM_006220779.2|",4021,0,"PREDICTED: Rattus norvegicus ankyrin repeat and fibronectin type-III domain-containing protein 1-like (LOC102551403), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam12796","Ank_2","Ankyrin repeats (3 copies).",".",".",".",".","."]
["ENSRNOG00000064685",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","ENSRNOG00000064685","protein_coding","chr4:69892629-69895491:+","gi|149065363|gb|EDM15439.1|",617,{"v":2e-72,"d":"2.00E-72"},"rCG28225, partial [Rattus norvegicus]","gi|298914777|emb|FQ232759.1|",496,0,"Rattus norvegicus TL0AEA64YI15 mRNA sequence","A0A1B0GX68",164,{"v":1e-45,"d":"1.00E-45"},"T cell receptor beta variable 2",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000064886",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","ENSRNOG00000064886","protein_coding","chr6:134815963-134816608:-","gi|149034299|gb|EDL89049.1|",624,{"v":3e-80,"d":"3.00E-80"},"rCG21088, partial [Rattus norvegicus]","gi|204780|gb|M84149.1|RATIGHVJ",373,0,"Rat IgH chain VJ region mRNA","P01753",169,{"v":3E-52,"d":"3.00E-52"},"Ig heavy chain V region 186-1",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000066203",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","ENSRNOG00000066203","protein_coding","chr4:98101666-98102555:+","gi|204706|gb|AAA41369.1|",605,{"v":1e-77,"d":"1.00E-77"},"immunoglobulin light chain [Rattus norvegicus]","gi|298897923|emb|FQ231113.1|",384,0,"Rattus norvegicus TL0AEA7YE11 mRNA sequence","P01631",190,{"v":1e-60,"d":"1.00E-60"},"Ig kappa chain V-II region 26-10",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000066542",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","ENSRNOG00000066542","protein_coding","chr1:2001544-2048250:-","gi|239787120|ref|NP_001155163.1|",1556,0,"Rae-1-like protein [Rattus norvegicus]","gi|239787119|ref|NM_001161691.1|",948,0,"Rattus norvegicus similar to retinoic acid early transcript 1L (Rrlt), mRNA","O08604",181,{"v":1E-51,"d":"1.00E-51"},"Retinoic acid early-inducible protein 1-gamma",".",".",".",".","pfam14586","MHC_I_2","Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2. Members of this family are known as retinoic-acid-inducible proteins. They are ligands for the activating immunoreceptor NKG2D, which is widely expressed on natural killer cells, T cells, and macrophages.",".",".",".",".","."]
["ENSRNOG00000067669",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","ENSRNOG00000067669","protein_coding","chr15:25696079-25696601:+","gi|433691|emb|CAA44204.1|",564,{"v":3e-72,"d":"3.00E-72"},"T cell receptor V-alpha J-alpha [Rattus rattus]","gi|433690|emb|X62329.1|",288,{"v":7e-148,"d":"7.00E-148"},"R.rattus TcRValphaQ4a13 mRNA for T cell receptor V-alpha J-alpha","A0A0B4J277",128,{"v":2e-37,"d":"2.00E-37"},"T cell receptor alpha variable 22",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000068186",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","ENSRNOG00000068186","protein_coding","chr12:19446094-19460522:+","gi|148687335|gb|EDL19282.1|",1855,0,"mCG6879, partial [Mus musculus]","gi|672072824|ref|XM_008769183.1|",1401,0,"PREDICTED: Rattus norvegicus mucin-3B-like (LOC100912943), transcript variant X2, mRNA","Q9H195",516,{"v":2e-152,"d":"2.00E-152"},"Mucin-3B (Fragments)",".",".",".",".","pfam01390","SEA","SEA domain. Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.",".",".",".",".","."]
["ENSRNOG00000068744",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","ENSRNOG00000068744","lncRNA","chr19:45836842-45841694:+",".",".",".",".","gi|37361088|gb|AC122036.3|",663,0,"Mus musculus BAC clone RP24-420C18 from chromosome 8, complete sequence",".",".",".",".",".",".",".",".","pfam06432","GPI2","Phosphatidylinositol N-acetylglucosaminyltransferase. Glycosylphosphatidylinositol (GPI) represents an important anchoring molecule for cell surface proteins. The first step in its synthesis is the transfer of N-acetylglucosamine (GlcNAc) from UDP-N-acetylglucosamine to phosphatidylinositol (PI). This step involves products of three or four genes in both yeast (GPI1, GPI2 and GPI3) and mammals (GPI1, PIG A, PIG H and PIG C), respectively.",".",".",".",".","."]
["ENSRNOG00000069193",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","ENSRNOG00000069193","protein_coding","chr4:98829126-98829737:+","gi|479224|pir||S32806",512,{"v":2e-63,"d":"2.00E-63"},"Ig kappa chain precursor - rat (fragment)","gi|298902151|emb|FQ231614.1|",361,0,"Rattus norvegicus TL0AEA68YN17 mRNA sequence","P01593",164,{"v":1E-50,"d":"1.00E-50"},"Immunoglobulin kappa variable 1D-33",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000069336",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","ENSRNOG00000069336","lncRNA","chr18:24516561-24530226:-",".",".",".",".","gi|58036716|gb|AC140983.4|",180,{"v":3e-87,"d":"3.00E-87"},"Mus musculus BAC clone RP23-167M17 from 18, complete sequence",".",".",".",".",".",".",".",".","pfam13625","Helicase_C_3","Helicase conserved C-terminal domain. This domain family is found in a wide variety of helicases and helicase-related proteins.",".",".",".",".","."]
["ENSRNOG00000070493",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","ENSRNOG00000070493","lncRNA","chr7:38180340-38187644:-",".",".",".",".","gi|672021605|ref|XR_601713.1|",818,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102555532 (LOC102555532), transcript variant X3, ncRNA",".",".",".",".",".",".",".",".","pfam13966","zf-RVT","zinc-binding in reverse transcriptase. This domain would appear to be a zinc-binding region of a putative reverse transcriptase.",".",".",".",".","."]
["ENSRNOG00000070718",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","ENSRNOG00000070718","protein_coding","chr4:101478730-101479360:-","gi|148666464|gb|EDK98880.1|",488,{"v":2e-60,"d":"2.00E-60"},"mCG141619, partial [Mus musculus]","gi|197033|gb|M19913.1|MUSIGKCNJ",200,{"v":8e-99,"d":"8.00E-99"},"Mouse Ig rearranged kappa-chain mRNA, clone AN11K","P01642",181,{"v":2e-57,"d":"2.00E-57"},"Ig kappa chain V-V region L7 (Fragment)",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000070789",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","ENSRNOG00000070789","lncRNA","chr20:42982705-42987217:+","gi|537251922|gb|ERE88519.1|",133,7e-06,"hypothetical protein H671_1g3002 [Cricetulus griseus]","gi|66912239|gb|AC160403.5|",333,{"v":1e-171,"d":"1.00E-171"},"Mus musculus 10 BAC RP24-286J14 (Roswell Park Cancer Institute (C57BL/6J Male) Mouse BAC Library) complete sequence",".",".",".",".",".",".",".",".","pfam03977","OAD_beta","Na+-transporting oxaloacetate decarboxylase beta subunit. Members of this family are integral membrane proteins. The decarboxylation reactions they catalyse are coupled to the vectorial transport of Na+ across the cytoplasmic membrane, thereby creating a sodium ion motive force that is used for ATP synthesis.",".",".",".",".","."]
["ENSRNOG00000071163",0,0.032165219,6,0.387371158,0.083034626,-3.59014312,0.020568648,0.010410663,"down","yes","ENSRNOG00000071163","protein_coding","chr4:101084329-101084907:-","gi|148666466|gb|EDK98882.1|",458,{"v":3e-56,"d":"3.00E-56"},"mCG1036630, partial [Mus musculus]","gi|197033|gb|M19913.1|MUSIGKCNJ",232,{"v":1e-116,"d":"1.00E-116"},"Mouse Ig rearranged kappa-chain mRNA, clone AN11K","P01642",172,{"v":3e-54,"d":"3.00E-54"},"Ig kappa chain V-V region L7 (Fragment)",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000068888",8,0.514643505,20,1.291237193,0.398566203,-1.327108714,0.020701606,0.010470535,"down","yes","ENSRNOG00000068888","lncRNA","chr17:6370507-6378539:-","gi|149039797|gb|EDL93913.1|",152,2E-8,"rCG24306, isoform CRA_a [Rattus norvegicus]","gi|186973223|gb|AC111867.5|",7907,0,"Rattus norvegicus BAC CH230-215N4 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam03025","Papilloma_E5","Papillomavirus E5. The E5 protein from papillomaviruses is about 80 amino acids long. The proteins are contain three regions that are predicted to be transmembrane alpha helices. The function of this protein is unknown.",".",".",".",".","."]
["ENSRNOG00000016716",12,0.771965258,26,1.678608351,0.459884081,-1.120657837,0.020973451,0.010581791,"down","yes","Armc3","protein_coding","chr17:81832518-81917531:+","gi|559098430|ref|NP_001273949.1|",3805,0,"armadillo repeat-containing protein 3 [Rattus norvegicus]","gi|559098429|ref|NM_001287020.1|",2755,0,"Rattus norvegicus armadillo repeat containing 3 (Armc3), mRNA","A2AU72",1357,0,"Armadillo repeat-containing protein 3",".",".",".",".","pfam14381","EDR1","Ethylene-responsive protein kinase Le-CTR1. EDR1 regulates disease resistance and ethylene-induced senescence, and is also involved in stress response signalling and cell death regulation.",".",".",".","K24124","ARMC3; armadillo repeat-containing protein 3"]
["ENSRNOG00000030246",12,0.771965258,26,1.678608351,0.459884081,-1.120657837,0.020973451,0.010581791,"down","yes","Btla","protein_coding","chr11:55564899-55587181:-","gi|47155571|ref|NP_998795.1|",1288,{"v":5e-158,"d":"5.00E-158"},"B- and T-lymphocyte attenuator precursor [Rattus norvegicus]","gi|672071184|ref|XM_006248341.2|",1828,0,"PREDICTED: Rattus norvegicus B and T lymphocyte associated (Btla), transcript variant X1, mRNA","Q6PNM1",500,{"v":2E-159,"d":"2.00E-159"},"B- and T-lymphocyte attenuator",".",".",".",".",".",".",".","GO:0002250|adaptive immune response;GO:0002768|immune response-regulating cell surface receptor signaling pathway;GO:0007166|cell surface receptor signaling pathway;GO:0030889|negative regulation of B cell proliferation;GO:0042130|negative regulation of T cell proliferation;GO:0046642|negative regulation of alpha-beta T cell proliferation;","GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;","GO:0038023|signaling receptor activity;","K06707","BTLA, CD272; B- and T-lymphocyte attenuator"]
["ENSRNOG00000016179",5,0.321652191,15,0.968427895,0.332138503,-1.59014312,0.021815069,0.010976355,"down","yes","Acoxl","protein_coding","chr3:115061060-115364686:+","gi|157817706|ref|NP_001099978.1|",3344,0,"acyl-coenzyme A oxidase-like protein [Rattus norvegicus]","gi|157817705|ref|NM_001106508.1|",3094,0,"Rattus norvegicus acyl-CoA oxidase-like (Acoxl), mRNA","Q9DBS4",1158,0,"Acyl-coenzyme A oxidase-like protein","YGL205w",172,{"v":1e-43,"d":"1.00E-43"},"COG1960","pfam00441","Acyl-CoA_dh_1","Acyl-CoA dehydrogenase, C-terminal domain. C-terminal domain of Acyl-CoA dehydrogenase is an all-alpha, four helical up-and-down bundle.","GO:0033540|fatty acid beta-oxidation using acyl-CoA oxidase;GO:0055088|lipid homeostasis;","GO:0005777|peroxisome;","GO:0003997|acyl-CoA oxidase activity;GO:0005504|fatty acid binding;GO:0050660|flavin adenine dinucleotide binding;GO:0071949|FAD binding;",".","."]
["ENSRNOG00000051159",5,0.321652191,15,0.968427895,0.332138503,-1.59014312,0.021815069,0.010976355,"down","yes","AABR07038578.1","pseudogene","chr10:36131492-36132150:-","gi|8394082|ref|NP_058981.1|",839,{"v":2e-111,"d":"2.00E-111"},"proteasome subunit beta type-3 [Rattus norvegicus]","gi|298914798|emb|FQ232780.1|",285,{"v":6e-146,"d":"6.00E-146"},"Rattus norvegicus TL0AEA64YH07 mRNA sequence","P40112",327,{"v":6e-113,"d":"6.00E-113"},"Proteasome subunit beta type-3","YER094c",182,{"v":9e-57,"d":"9.00E-57"},"COG0638","pfam00227","Proteasome","Proteasome subunit. The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria. The second is call beta-proteobacteria proteasome homologue (BPH).",".",".",".",".","."]
["ENSRNOG00000059362",5,0.321652191,15,0.968427895,0.332138503,-1.59014312,0.021815069,0.010976355,"down","yes","Has3","protein_coding","chr19:34771982-34782592:+","gi|27229288|ref|NP_758822.1|",2838,0,"hyaluronan synthase 3 [Rattus norvegicus]","gi|672084737|ref|XM_006255561.2|",2294,0,"PREDICTED: Rattus norvegicus hyaluronan synthase 3 (Has3), transcript variant X1, mRNA","O08650",1091,0,"Hyaluronan synthase 3","mlr6163",133,{"v":3E-32,"d":"3.00E-32"},"COG1215","pfam03142","Chitin_synth_2","Chitin synthase. Members of this family are fungal chitin synthase EC:2.4.1.16 enzymes. They catalyse chitin synthesis as follows: UDP-N-acetyl-D-glucosamine + {(1,4)-(N-acetyl-beta-D-glucosaminyl)}(N) <=> UDP + {(1,4)-(N-acetyl-beta-D-glucosaminyl)}(N+1).","GO:0030213|hyaluronan biosynthetic process;GO:0045226|extracellular polysaccharide biosynthetic process;GO:0045893|positive regulation of transcription, DNA-templated;GO:0085029|extracellular matrix assembly;GO:1900106|positive regulation of hyaluranon cable assembly;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005887|integral component of plasma membrane;GO:0036117|hyaluranon cable;","GO:0042802|identical protein binding;GO:0050501|hyaluronan synthase activity;","K00752","hasA; hyaluronan synthase [EC:2.4.1.212]"]
["ENSRNOG00000063198",5,0.321652191,15,0.968427895,0.332138503,-1.59014312,0.021815069,0.010976355,"down","yes","ENSRNOG00000063198","lncRNA","chr14:76172103-76175331:+","gi|148701441|gb|EDL33388.1|",219,{"v":7e-18,"d":"7.00E-18"},"mCG1045525, partial [Mus musculus]","gi|34482112|gb|AC132346.3|",143,{"v":2E-66,"d":"2.00E-66"},"Mus musculus BAC clone RP24-179K8 from chromosome 3, complete sequence","P46935",53.1,9e-06,"E3 ubiquitin-protein ligase NEDD4",".",".",".",".","pfam12997","DUF3881","Domain of unknown function, E. rectale Gene description (DUF3881). Based on Eubacterium rectale gene EUBREC_3695. As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE14737), it appears to be upregulated in the presence of Bacteroides thetaiotaomicron vs when isolated in culture.",".",".",".",".","."]
["ENSRNOG00000070111",5,0.321652191,15,0.968427895,0.332138503,-1.59014312,0.021815069,0.010976355,"down","yes","Apol2","protein_coding","chr7:109331392-109338558:-","gi|392341617|ref|XP_001075828.3|",1457,0,"PREDICTED: apolipoprotein L2 isoform X2 [Rattus norvegicus]","gi|672060336|ref|XM_006241955.2|",2016,0,"PREDICTED: Rattus norvegicus apolipoprotein L3-like (LOC100911804), transcript variant X6, mRNA","Q9BQE5",167,{"v":2e-43,"d":"2.00E-43"},"Apolipoprotein L2",".",".",".",".","pfam05461","ApoL","Apolipoprotein L. Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.",".",".",".",".","."]
["ENSRNOG00000012424",15,0.964956573,30,1.93685579,0.498207754,-1.005180619,0.02326075,0.011659588,"down","yes","Adam23","protein_coding","chr9:64862878-65006515:+","gi|71361651|ref|NP_001025070.1|",4226,0,"disintegrin and metalloproteinase domain-containing protein 23 [Rattus norvegicus]","gi|71361650|ref|NM_001029899.1|",2856,0,"Rattus norvegicus ADAM metallopeptidase domain 23 (Adam23), mRNA","Q9R1V7",1539,0,"Disintegrin and metalloproteinase domain-containing protein 23",".",".",".",".","pfam01421","Reprolysin","Reprolysin (M12B) family zinc metalloprotease. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as human ADAM8 and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.","GO:0006508|proteolysis;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0098978|glutamatergic synapse;GO:0099056|integral component of presynaptic membrane;","GO:0004222|metalloendopeptidase activity;","K06837","ADAM23; disintegrin and metalloproteinase domain-containing protein 23 [EC:3.4.24.-]"]
["ENSRNOG00000067332",13,0.836295696,27,1.743170211,0.479755615,-1.059628403,0.024577794,0.012278813,"down","yes","ENSRNOG00000067332","lncRNA","chr4:63927513-63940467:+","gi|148681719|gb|EDL13666.1|",171,{"v":1E-13,"d":"1.00E-13"},"mCG21757, isoform CRA_a [Mus musculus]","gi|307344636|ref|NM_001195504.1|",624,0,"Rattus norvegicus hypothetical protein LOC689574 (LOC689574), transcript variant 2, mRNA","E0CX11",73.6,{"v":8E-14,"d":"8.00E-14"},"Short transmembrane mitochondrial protein 1",".",".",".",".","pfam15054","DUF4535","Domain of unknown function (DUF4535). This family includes the uncharacterized protein C7orf73 that is found in eukaryotes. Members are generally less than 100 residues in length. Although the precise function of the domain is still unknown, members have a predicted N-terminal signal peptide sequence which suggests they are short secreted peptides.",".",".",".",".","."]
["ENSRNOG00000007348",7,0.450313067,18,1.162113474,0.38749492,-1.367750699,0.024703743,0.012334183,"down","yes","ENSRNOG00000007348","protein_coding","chr7:10980344-10987036:+","gi|47577991|ref|NP_001000418.1|",1640,0,"olfactory receptor Olr1087 [Rattus norvegicus]","gi|47577990|ref|NM_001000418.1|",942,0,"Rattus norvegicus olfactory receptor 1087 (Olr1087), mRNA","O60431",464,{"v":3E-158,"d":"3.00E-158"},"Olfactory receptor 1I1",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0050911|detection of chemical stimulus involved in sensory perception of smell;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004984|olfactory receptor activity;","K04257","OLFR; olfactory receptor"]
["ENSRNOG00000021128",4,0.257321753,13,0.839304176,0.306589387,-1.705620337,0.02477551,0.012360291,"down","yes","Kcnj11","protein_coding","chr1:96591049-96594082:-","gi|19923693|ref|NP_112648.2|",1979,0,"ATP-sensitive inward rectifier potassium channel 11 [Rattus norvegicus]","gi|169235013|gb|AC120807.4|",3034,0,"Rattus norvegicus BAC CH230-92D18 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P70673",766,0,"ATP-sensitive inward rectifier potassium channel 11",".",".",".",".","pfam01007","IRK","Inward rectifier potassium channel.","GO:0002931|response to ischemia;GO:0006006|glucose metabolic process;GO:0006813|potassium ion transport;GO:0009410|response to xenobiotic stimulus;GO:0032355|response to estradiol;GO:0033198|response to ATP;GO:0033574|response to testosterone;GO:0034765|regulation of ion transmembrane transport;GO:0042391|regulation of membrane potential;GO:0046676|negative regulation of insulin secretion;GO:0050796|regulation of insulin secretion;GO:0050877|nervous system process;GO:0071316|cellular response to nicotine;GO:0071333|cellular response to glucose stimulus;GO:0071356|cellular response to tumor necrosis factor;GO:0071805|potassium ion transmembrane transport;GO:0098662|inorganic cation transmembrane transport;GO:1903078|positive regulation of protein localization to plasma membrane;GO:1990573|potassium ion import across plasma membrane;GO:2001259|positive regulation of cation channel activity;","GO:0001669|acrosomal vesicle;GO:0005635|nuclear envelope;GO:0005739|mitochondrion;GO:0005768|endosome;GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0008282|inward rectifying potassium channel;GO:0014704|intercalated disc;GO:0030315|T-tubule;GO:0030673|axolemma;GO:0042383|sarcolemma;GO:0043025|neuronal cell body;GO:0043209|myelin sheath;GO:0043231|intracellular membrane-bounded organelle;GO:0070852|cell body fiber;","GO:0005242|inward rectifier potassium channel activity;GO:0005249|voltage-gated potassium channel activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0008022|protein C-terminus binding;GO:0015272|ATP-activated inward rectifier potassium channel activity;GO:0019829|cation-transporting ATPase activity;GO:0030506|ankyrin binding;GO:0031072|heat shock protein binding;GO:0044325|ion channel binding;","K05004","KCNJ11, KIR6.2; potassium inwardly-rectifying channel subfamily J member 11"]
["ENSRNOG00000028440",4,0.257321753,13,0.839304176,0.306589387,-1.705620337,0.02477551,0.012360291,"down","yes","Apcdd1l","protein_coding","chr3:162582252-162658073:-","gi|672017828|ref|XP_006224822.2|",1972,0,"PREDICTED: protein APCDD1-like isoform X1 [Rattus norvegicus]","gi|672017827|ref|XM_006224760.2|",2169,0,"PREDICTED: Rattus norvegicus adenomatosis polyposis coli down-regulated 1-like (Apcdd1l), transcript variant X1, mRNA","Q8NCL9",513,{"v":2e-173,"d":"2.00E-173"},"Protein APCDD1-like",".",".",".",".","pfam14921","APCDDC","Adenomatosis polyposis coli down-regulated 1. The domain is duplicated in most members of this family. APCDD is directly regulated by the beta-catenin/Tcf complex, and its elevated expression promotes proliferation of colonic epithelial cells in vitro and in vivo. APCDD1 has an N-terminal signal-peptide and a C-terminal transmembrane region. The domain is rich in cysteines, there being up to 12 such residues, a structural motif important for interaction between Wnt ligands and their receptors. APCDD1 is expressed in a broad repertoire of cell types, indicating that it may regulate a diverse range of biological processes controlled by Wnt signalling.","GO:0030178|negative regulation of Wnt signaling pathway;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0017147|Wnt-protein binding;",".","."]
["ENSRNOG00000035531",4,0.257321753,13,0.839304176,0.306589387,-1.705620337,0.02477551,0.012360291,"down","yes","Mir25","miRNA","chr12:17042932-17043015:-",".",".",".",".","gi|297139681|ref|NR_031829.1|",84,{"v":3e-35,"d":"3.00E-35"},"Rattus norvegicus microRNA 25 (Mir25), microRNA",".",".",".",".",".",".",".",".","pfam13647","Glyco_hydro_80","Glycosyl hydrolase family 80 of chitosanase A. This is a small family of bacterial chitosanases.","GO:0001701|in utero embryonic development;GO:0002903|negative regulation of B cell apoptotic process;GO:0007569|cell aging;GO:0007605|sensory perception of sound;GO:0043066|negative regulation of apoptotic process;GO:0060291|long-term synaptic potentiation;GO:0060395|SMAD protein signal transduction;GO:0071241|cellular response to inorganic substance;GO:1904322|cellular response to forskolin;",".",".","K17038","MIR25; microRNA 25"]
["ENSRNOG00000046850",4,0.257321753,13,0.839304176,0.306589387,-1.705620337,0.02477551,0.012360291,"down","yes","Thpol1","protein_coding","chr11:80182820-80188167:+","gi|13592113|ref|NP_112395.1|",1268,{"v":3e-169,"d":"3.00E-169"},"thrombopoietin precursor [Rattus norvegicus]","gi|51260655|gb|BC078802.1|",1587,0,"Rattus norvegicus thrombopoietin, mRNA (cDNA clone IMAGE:7126144), with apparent retained intron","P49745",493,{"v":1e-170,"d":"1.00E-170"},"Thrombopoietin",".",".",".",".","pfam00758","EPO_TPO","Erythropoietin/thrombopoietin.",".",".",".","K06854","THPO; thrombopoietin"]
["ENSRNOG00000051906",4,0.257321753,13,0.839304176,0.306589387,-1.705620337,0.02477551,0.012360291,"down","yes","AABR07035561.2","protein_coding","chr12:17364080-17365280:+","gi|149028544|gb|EDL83916.1|",924,{"v":9e-124,"d":"9.00E-124"},"rCG55971, partial [Rattus norvegicus]","gi|672026601|ref|XM_006221297.2|",628,0,"PREDICTED: Rattus norvegicus similar to paired immunoglobin-like type 2 receptor beta (LOC680923), transcript variant X3, mRNA","Q6DKI7",171,{"v":1e-49,"d":"1.00E-49"},"Transmembrane protein PVRIG",".",".",".",".","pfam00387","PI-PLC-Y","Phosphatidylinositol-specific phospholipase C, Y domain. This associates with pfam00388 to form a single structural unit.",".",".",".",".","."]
["ENSRNOG00000057665",4,0.257321753,13,0.839304176,0.306589387,-1.705620337,0.02477551,0.012360291,"down","yes","U6","snRNA","chr6:95474146-95474248:+",".",".",".",".","gi|953266979|ref|NG_045462.1|",64,{"v":6e-24,"d":"6.00E-24"},"Homo sapiens RNA, U6 small nuclear 32, pseudogene (RNU6-32P) on chromosome 4",".",".",".",".",".",".",".",".","pfam09984","DUF2222","Uncharacterized signal transduction histidine kinase domain (DUF2222). Members of this family of domains are found in various BarA-like signal transduction histidine kinases, which are involved in the regulation of carbon metabolizm via the csrA/csrB regulatory system. The role of this domain has not, as yet, been established.",".",".",".",".","."]
["ENSRNOG00000067173",4,0.257321753,13,0.839304176,0.306589387,-1.705620337,0.02477551,0.012360291,"down","yes","ENSRNOG00000067173","protein_coding","chr10:14958163-14960933:-","gi|148690529|gb|EDL22476.1|",1327,{"v":6e-166,"d":"6.00E-166"},"mCG48762 [Mus musculus]","gi|34368593|gb|AC126071.5|",1938,0,"Rattus norvegicus 10 BAC CH230-209B21 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam15449","Retinal","Retinal protein. This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.",".",".",".",".","."]
["ENSRNOG00000069622",4,0.257321753,13,0.839304176,0.306589387,-1.705620337,0.02477551,0.012360291,"down","yes","U6","snRNA","chr8:19011408-19011517:+",".",".",".",".","gi|937346751|ref|NG_043293.1|",43,{"v":3e-12,"d":"3.00E-12"},"Homo sapiens RNA, U6 small nuclear 71, pseudogene (RNU6-71P) on chromosome 13",".",".",".",".",".",".",".",".","pfam09996","DUF2237","Uncharacterized protein conserved in bacteria (DUF2237). This domain, found in various hypothetical bacterial proteins, has no known function.",".",".",".",".","."]
["ENSRNOG00000002079",1,0.064330438,7,0.451933018,0.142345073,-2.812535541,0.024945437,0.012417948,"down","yes","Mapk10","protein_coding","chr14:6497707-6786201:+","gi|488566167|ref|XP_004472751.1|",2291,0,"PREDICTED: mitogen-activated protein kinase 10 isoform X1 [Dasypus novemcinctus]","gi|395759214|ref|NM_012806.2|",2757,0,"Rattus norvegicus mitogen activated protein kinase 10 (Mapk10), transcript variant 2, mRNA","Q61831",862,0,"Mitogen-activated protein kinase 10",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0000165|MAPK cascade;GO:0006468|protein phosphorylation;GO:0007254|JNK cascade;GO:0007258|JUN phosphorylation;GO:0009414|response to water deprivation;GO:0009416|response to light stimulus;GO:0035556|intracellular signal transduction;GO:0042752|regulation of circadian rhythm;GO:0045475|locomotor rhythm;GO:0048511|rhythmic process;GO:0071474|cellular hyperosmotic response;GO:0098969|neurotransmitter receptor transport to postsynaptic membrane;GO:0099003|vesicle-mediated transport in synapse;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0043005|neuron projection;GO:0043204|perikaryon;GO:0098978|glutamatergic synapse;","GO:0004674|protein serine/threonine kinase activity;GO:0004705|JUN kinase activity;GO:0004707|MAP kinase activity;GO:0005515|protein binding;GO:0005524|ATP binding;","K04440","JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]"]
["ENSRNOG00000002555",1,0.064330438,7,0.451933018,0.142345073,-2.812535541,0.024945437,0.012417948,"down","yes","Serpinb7","protein_coding","chr13:23395671-23442205:+","gi|564380159|ref|XP_006249691.1|",1866,0,"PREDICTED: serpin B7 isoform X1 [Rattus norvegicus]","gi|298908490|emb|FQ228843.1|",1924,0,"Rattus norvegicus TL0ADA51YD11 mRNA sequence","Q9D695",663,0,"Serpin B7","MA2246",168,{"v":6e-45,"d":"6.00E-45"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0010951|negative regulation of endopeptidase activity;GO:0032914|positive regulation of transforming growth factor beta1 production;GO:0032967|positive regulation of collagen biosynthetic process;GO:0072126|positive regulation of glomerular mesangial cell proliferation;GO:0090362|positive regulation of platelet-derived growth factor production;","GO:0005575|cellular_component;GO:0005615|extracellular space;","GO:0003674|molecular_function;GO:0004867|serine-type endopeptidase inhibitor activity;","K13964","SERPINB7; serpin B7"]
["ENSRNOG00000006093",1,0.064330438,7,0.451933018,0.142345073,-2.812535541,0.024945437,0.012417948,"down","yes","LRRTM1","protein_coding","chr4:109701815-109717184:+","gi|157820119|ref|NP_001102844.1|",2595,0,"leucine-rich repeat transmembrane neuronal protein 1 precursor [Rattus norvegicus]","gi|157820118|ref|NM_001109374.1|",2923,0,"Rattus norvegicus leucine rich repeat transmembrane neuronal 1 (LRRTM1), mRNA","D4A6D8",988,0,"Leucine-rich repeat transmembrane neuronal protein 1","SPy1798",92.8,{"v":3e-18,"d":"3.00E-18"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0002091|negative regulation of receptor internalization;GO:0007626|locomotory behavior;GO:0035418|protein localization to synapse;GO:0035640|exploration behavior;GO:0050808|synapse organization;GO:0051965|positive regulation of synapse assembly;GO:0060291|long-term synaptic potentiation;GO:0099151|regulation of postsynaptic density assembly;GO:1905606|regulation of presynapse assembly;","GO:0005615|extracellular space;GO:0005783|endoplasmic reticulum;GO:0030424|axon;GO:0030426|growth cone;GO:0031012|extracellular matrix;GO:0060076|excitatory synapse;GO:0098978|glutamatergic synapse;GO:0098982|GABA-ergic synapse;GO:0099055|integral component of postsynaptic membrane;GO:0099060|integral component of postsynaptic specialization membrane;",".","K16665","LRRTM1_2; leucine-rich repeat transmembrane neuronal protein 1/2"]
["ENSRNOG00000009181",1,0.064330438,7,0.451933018,0.142345073,-2.812535541,0.024945437,0.012417948,"down","yes","Dleu7","protein_coding","chr15:36479534-36495697:-","gi|157823151|ref|NP_001099513.1|",781,{"v":3e-97,"d":"3.00E-97"},"leukemia-associated protein 7 [Rattus norvegicus]","gi|157823150|ref|NM_001106043.1|",1693,0,"Rattus norvegicus deleted in lymphocytic leukemia, 7 (Dleu7), mRNA",".",".",".",".",".",".",".",".","pfam11951","Fungal_trans_2","Fungal specific transcription factor domain. This family of are likely to be transcription factors. This protein is found in fungi. Proteins in this family are typically between 454 to 826 amino acids in length. This protein is found associated with pfam00172.",".",".",".",".","."]
["ENSRNOG00000011907",1,0.064330438,7,0.451933018,0.142345073,-2.812535541,0.024945437,0.012417948,"down","yes","Krt23","protein_coding","chr10:84434380-84450983:-","gi|149054171|gb|EDM05988.1|",1836,0,"rCG64355 [Rattus norvegicus]","gi|56847623|ref|NM_001008753.1|",1253,0,"Rattus norvegicus keratin 23, type I (Krt23), mRNA","Q99PS0",672,0,"Keratin, type I cytoskeletal 23",".",".",".",".","pfam00038","Filament","Intermediate filament protein.",".","GO:0005882|intermediate filament;","GO:0005198|structural molecule activity;","K07604","KRT1; type I keratin, acidic"]
["ENSRNOG00000012697",1,0.064330438,7,0.451933018,0.142345073,-2.812535541,0.024945437,0.012417948,"down","yes","Spaca9","protein_coding","chr3:12019363-12029119:-","gi|564339913|ref|XP_006233824.1|",1345,{"v":1E-180,"d":"1.00E-180"},"PREDICTED: uncharacterized protein C9orf9 homolog isoform X1 [Rattus norvegicus]","gi|564339912|ref|XM_006233762.1|",999,0,"PREDICTED: Rattus norvegicus Rsb-66 protein (Rsb66), transcript variant X1, mRNA","Q96E40",362,{"v":3e-120,"d":"3.00E-120"},"Sperm acrosome-associated protein 9",".",".",".",".","pfam15120","DUF4561","Domain of unknown function (DUF4561). This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes.",".","GO:0001669|acrosomal vesicle;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005881|cytoplasmic microtubule;GO:0036064|ciliary basal body;GO:0036126|sperm flagellum;GO:0097546|ciliary base;","GO:0005515|protein binding;GO:0048306|calcium-dependent protein binding;","K25516","SPACA9; sperm acrosome membrane-associated protein 9"]
["ENSRNOG00000020630",1,0.064330438,7,0.451933018,0.142345073,-2.812535541,0.024945437,0.012417948,"down","yes","Il9r","protein_coding","chr10:15431706-15441990:+","gi|149052205|gb|EDM04022.1|",2314,0,"interleukin 9 receptor, isoform CRA_a [Rattus norvegicus]","gi|8393601|ref|NM_017021.1|",2493,0,"Rattus norvegicus interleukin 9 receptor (Il9r), mRNA","Q01114",724,0,"Interleukin-9 receptor",".",".",".",".","pfam05020","zf-NPL4","NPL4 family, putative zinc binding region. The HRD4 gene was identical to NPL4, a gene previously implicated in nuclear transport. Using a diverse set of substrates and direct ubiquitination assays, analysis revealed that HRD4/NPL4 is required for a poorly characterized step in ER-associated degradation after ubiquitination of target proteins but before their recognition by the 26S proteasome. This region of the protein contains possibly two zinc binding motifs (Bateman A pers. obs.). Npl4p physically associates with Cdc48p via Ufd1p to form a Cdc48p-Ufd1p-Npl4p complex. The Cdc48-Ufd1-Npl4 complex functions in the recognition of several polyubiquitin-tagged proteins and facilitates their presentation to the 26S proteasome for processive degradation or even more specific processing.","GO:0016064|immunoglobulin mediated immune response;GO:0030183|B cell differentiation;GO:0030307|positive regulation of cell growth;GO:0038113|interleukin-9-mediated signaling pathway;GO:0042100|B cell proliferation;GO:0050730|regulation of peptidyl-tyrosine phosphorylation;GO:2001268|negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0004919|interleukin-9 receptor activity;GO:0019983|interleukin-9 binding;","K05073","IL9R, CD129; interleukin 9 receptor"]
["ENSRNOG00000029131",1,0.064330438,7,0.451933018,0.142345073,-2.812535541,0.024945437,0.012417948,"down","yes","AABR07024637.1","protein_coding","chr16:8757705-8877303:+","gi|672029050|ref|XP_008769325.1|",6838,0,"PREDICTED: FERM and PDZ domain-containing protein 2 isoform X1 [Rattus norvegicus]","gi|672029049|ref|XM_008771103.1|",4993,0,"PREDICTED: Rattus norvegicus FERM and PDZ domain containing 2 (Frmpd2), transcript variant X1, mRNA","Q68DX3",1701,0,"FERM and PDZ domain-containing protein 2",".",".",".",".","pfam00373","FERM_M","FERM central domain. This domain is the central structural domain of the FERM domain.",".",".",".",".","."]
["ENSRNOG00000034236",1,0.064330438,7,0.451933018,0.142345073,-2.812535541,0.024945437,0.012417948,"down","yes","C2cd4a","protein_coding","chr8:68466664-68470031:-","gi|672023050|ref|XP_008774980.1|",1187,{"v":2e-151,"d":"2.00E-151"},"PREDICTED: C2 calcium-dependent domain-containing protein 4A [Rattus norvegicus]","gi|672023049|ref|XM_008776758.1|",2461,0,"PREDICTED: Rattus norvegicus C2 calcium-dependent domain containing 4A (C2cd4a), transcript variant X1, mRNA","Q8NCU7",150,{"v":1e-37,"d":"1.00E-37"},"C2 calcium-dependent domain-containing protein 4A",".",".",".",".","pfam09459","EB_dh","Ethylbenzene dehydrogenase. Eythylbenzene dehydrogenase is a heterotrimer of three subunits that catalyses the anaerobic degradation of hydrocarbons. The alpha subunit contains the catalytic centre as a Molybdenum cofactor-complex. This removes an electron-pair from the hydrocarbon and passes it along an electron transport system involving iron-sulphur complexes held in the beta subunit and a Haem b molecule contained in the gamma subunit. The electron-pair is then subsequently passed to an as yet unknown receiver. The enzyme is found in a variety of different bacteria.","GO:0002528|regulation of vascular permeability involved in acute inflammatory response;GO:0002675|positive regulation of acute inflammatory response;GO:0030155|regulation of cell adhesion;","GO:0005634|nucleus;",".",".","."]
["ENSRNOG00000048771",1,0.064330438,7,0.451933018,0.142345073,-2.812535541,0.024945437,0.012417948,"down","yes","RGD1559482","protein_coding","chr10:100136867-100140427:+","gi|293340561|ref|XP_001081656.2|",1068,{"v":3e-144,"d":"3.00E-144"},"PREDICTED: CMRF35-like molecule isoform X1 [Rattus norvegicus]","gi|672070031|ref|XM_577143.5|",869,0,"PREDICTED: Rattus norvegicus similar to leukocyte mono-Ig-like receptor2 (RGD1562667), transcript variant X1, mRNA","Q7TSN2",271,{"v":8e-89,"d":"8.00E-89"},"CMRF35-like molecule",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004888|transmembrane signaling receptor activity;","K06719","CD300; CD300 antigen"]
["ENSRNOG00000050758",1,0.064330438,7,0.451933018,0.142345073,-2.812535541,0.024945437,0.012417948,"down","yes","AC142154.1","protein_coding","chr1:81932016-81934442:-","gi|157819605|ref|NP_001102051.1|",3528,0,"enhancer of polycomb homolog 2 [Rattus norvegicus]","gi|157819604|ref|NM_001108581.1|",2400,0,"Rattus norvegicus enhancer of polycomb homolog 2 (Epc2), mRNA","Q8C0I4",1346,0,"Enhancer of polycomb homolog 2",".",".",".",".","pfam06752","E_Pc_C","Enhancer of Polycomb C-terminus. This family represents the C-terminus of eukaryotic enhancer of polycomb proteins, which have roles in heterochromatin formation. This family contains several conserved motifs.",".",".",".",".","."]
["ENSRNOG00000054912",1,0.064330438,7,0.451933018,0.142345073,-2.812535541,0.024945437,0.012417948,"down","yes","U6","snRNA","chr11:83361314-83361420:-","gi|965792038|ref|XP_014963564.1|",156,{"v":3E-11,"d":"3.00E-11"},"PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC106992171 [Ovis aries musimon]","gi|672071836|ref|XM_008768921.1|",107,{"v":7e-48,"d":"7.00E-48"},"PREDICTED: Rattus norvegicus coiled-coil domain containing 74A (Ccdc74a), transcript variant X4, mRNA",".",".",".",".",".",".",".",".","pfam06692","MNSV_P7B","Melon necrotic spot virus P7B protein. This family consists of several Melon necrotic spot virus (MNSV) P7B proteins. The function of this family is unknown.",".",".",".",".","."]
["ENSRNOG00000056526",1,0.064330438,7,0.451933018,0.142345073,-2.812535541,0.024945437,0.012417948,"down","yes","AABR07054262.1","protein_coding","chr3:138778150-138779864:-","gi|568907574|ref|XP_006496503.1|",1707,0,"PREDICTED: arf-GAP domain and FG repeat-containing protein 1 isoform X11 [Mus musculus]","gi|676260353|ref|NG_008661.2|",608,0,"Rattus norvegicus ArfGAP with FG repeats 1, pseudogene 1 (Agfg1-ps1) on chromosome 3","Q8K2K6",646,0,"Arf-GAP domain and FG repeat-containing protein 1","SPCC622.14",64.3,{"v":1E-10,"d":"1.00E-10"},"COG5347","pfam01412","ArfGap","Putative GTPase activating protein for Arf. Putative zinc fingers with GTPase activating proteins (GAPs) towards the small GTPase, Arf. The GAP of ARD1 stimulates GTPase hydrolysis for ARD1 but not ARFs.",".",".",".",".","."]
["ENSRNOG00000059108",1,0.064330438,7,0.451933018,0.142345073,-2.812535541,0.024945437,0.012417948,"down","yes","U7","snRNA","chr17:43105460-43105522:+",".",".",".",".","gi|351735276|emb|AL589742.22|",51,{"v":4e-17,"d":"4.00E-17"},"Mouse DNA sequence from clone RP23-298F22 on chromosome 13, complete sequence",".",".",".",".",".",".",".",".","pfam12781","AAA_9","ATP-binding dynein motor region D5. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D5 ATP-binding region of the motor, but has lost its P-loop.",".",".",".",".","."]
["ENSRNOG00000063571",1,0.064330438,7,0.451933018,0.142345073,-2.812535541,0.024945437,0.012417948,"down","yes","ENSRNOG00000063571","lncRNA","chr11:30673221-30703450:-",".",".",".",".","gi|49615110|gb|AC120974.7|",1258,0,"Rattus norvegicus 11 BAC CH230-358O2 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam15087","DUF4551","Protein of unknown function (DUF4551). This family of proteins is functionally uncharacterized. This family of proteins is found in metazoa. This family includes human protein C12orf56.",".",".",".",".","."]
["ENSRNOG00000064116",1,0.064330438,7,0.451933018,0.142345073,-2.812535541,0.024945437,0.012417948,"down","yes","U4","snRNA","chr5:150055348-150055488:+","gi|927205081|ref|XP_013838392.1|",196,{"v":5e-17,"d":"5.00E-17"},"PREDICTED: NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X1 [Sus scrofa]","gi|371922929|dbj|AK396339.1|",135,{"v":3e-63,"d":"3.00E-63"},"Sus scrofa mRNA, clone: PST010012C02, expressed in prostate",".",".",".",".",".",".",".",".","pfam04363","DUF496","Protein of unknown function (DUF496).",".",".",".",".","."]
["ENSRNOG00000067476",1,0.064330438,7,0.451933018,0.142345073,-2.812535541,0.024945437,0.012417948,"down","yes","ENSRNOG00000067476","lncRNA","chr9:41232898-41234226:+",".",".",".",".","gi|56382171|gb|AC101277.16|",229,{"v":2e-114,"d":"2.00E-114"},"Mus musculus chromosome 1, clone RP23-101P2, complete sequence",".",".",".",".",".",".",".",".","pfam05766","NinG","Bacteriophage Lambda NinG protein. NinG or Rap is involved in recombination. Rap (recombination adept with plasmid) increases lambda-by-plasmid recombination catalysed by Escherichia coli's RecBCD pathway.",".",".",".",".","."]
["ENSRNOG00000069885",1,0.064330438,7,0.451933018,0.142345073,-2.812535541,0.024945437,0.012417948,"down","yes","ENSRNOG00000069885","lncRNA","chr2:185576800-185607833:+","gi|149030536|gb|EDL85573.1|",160,{"v":2e-10,"d":"2.00E-10"},"rCG51798 [Rattus norvegicus]","gi|74013585|gb|AC164091.3|",442,0,"Mus musculus BAC clone RP23-97M20 from chromosome 3, complete sequence",".",".",".",".",".",".",".",".","pfam04116","FA_hydroxylase","Fatty acid hydroxylase superfamily. This superfamily includes fatty acid and carotene hydroxylases and sterol desaturases. Beta-carotene hydroxylase is involved in zeaxanthin synthesis by hydroxylating beta-carotene, but the enzyme may be involved in other pathways. This family includes C-5 sterol desaturase and C-4 sterol methyl oxidase. Members of this family are involved in cholesterol biosynthesis and biosynthesis a plant cuticular wax. These enzymes contain two copies of a HXHH motif. Members of this family are integral membrane proteins.",".",".",".",".","."]
["ENSRNOG00000070557",11,0.70763482,24,1.549484632,0.456690441,-1.130711501,0.025489618,0.012653551,"down","yes","ENSRNOG00000070557","snoRNA","chr10:15284997-15285098:-",".",".",".",".","gi|31376410|gb|AC096051.7|",102,{"v":4e-45,"d":"4.00E-45"},"Rattus norvegicus 10 BAC CH230-21G1 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam00007","Cys_knot","Cystine-knot domain. The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.",".",".",".",".","."]
["ENSRNOG00000071112",11,0.70763482,24,1.549484632,0.456690441,-1.130711501,0.025489618,0.012653551,"down","yes","ENSRNOG00000071112","lncRNA","chr10:88074662-88076733:+","gi|149025935|gb|EDL82178.1|",137,9e-07,"rCG28938 [Rattus norvegicus]","gi|672069529|ref|XM_006247518.2|",2072,0,"PREDICTED: Rattus norvegicus hexamethylene bis-acetamide inducible 2 (Hexim2), transcript variant X10, mRNA",".",".",".",".",".",".",".",".","pfam03638","TCR","Tesmin/TSO1-like CXC domain, cysteine-rich domain. This family includes proteins that have two copies of a cysteine rich motif as follows: C-X-C-X4-C-X3-YC-X-C-X6-C-X3-C-X-C-X2-C. The family includes Tesmin and TSO1. This family is called a CXC domain in.",".",".",".",".","."]
["ENSRNOG00000003304",9,0.578973944,21,1.355799053,0.427035218,-1.227573041,0.0256899,0.012739686,"down","yes","Chad","protein_coding","chr10:79511931-79515940:+","gi|564373931|ref|XP_006247248.1|",1954,0,"PREDICTED: chondroadherin isoform X1 [Rattus norvegicus]","gi|9506482|ref|NM_019164.1|",1654,0,"Rattus norvegicus chondroadherin (Chad), mRNA","O70210",665,0,"Chondroadherin","SPy1798",61.2,7e-09,"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0001502|cartilage condensation;GO:0060348|bone development;GO:1900155|negative regulation of bone trabecula formation;","GO:0005615|extracellular space;GO:0016021|integral component of membrane;GO:0031012|extracellular matrix;",".","K06248","CHAD; chondroadherin"]
["ENSRNOG00000001575",3,0.192991315,11,0.710180456,0.271749684,-1.879649737,0.027238164,0.013451413,"down","yes","Grik1","protein_coding","chr11:27169740-27570645:-","gi|163659911|ref|NP_001104587.1|",4764,0,"glutamate receptor ionotropic, kainate 1 isoform 1 [Rattus norvegicus]","gi|163659910|ref|NM_001111117.1|",3313,0,"Rattus norvegicus glutamate ionotropic receptor kainate type subunit 1 (Grik1), transcript variant 1, mRNA","P22756",1825,0,"Glutamate receptor ionotropic, kainate 1",".",".",".",".","pfam00060","Lig_chan","Ligand-gated ion channel. This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.","GO:0007268|chemical synaptic transmission;GO:0007399|nervous system development;GO:0014054|positive regulation of gamma-aminobutyric acid secretion;GO:0015813|L-glutamate transmembrane transport;GO:0030534|adult behavior;GO:0032229|negative regulation of synaptic transmission, GABAergic;GO:0032230|positive regulation of synaptic transmission, GABAergic;GO:0034220|ion transmembrane transport;GO:0035235|ionotropic glutamate receptor signaling pathway;GO:0035249|synaptic transmission, glutamatergic;GO:0042391|regulation of membrane potential;GO:0048167|regulation of synaptic plasticity;GO:0048172|regulation of short-term neuronal synaptic plasticity;GO:0048266|behavioral response to pain;GO:0050804|modulation of chemical synaptic transmission;GO:0051899|membrane depolarization;GO:0051967|negative regulation of synaptic transmission, glutamatergic;GO:0060079|excitatory postsynaptic potential;GO:0060080|inhibitory postsynaptic potential;","GO:0005886|plasma membrane;GO:0008328|ionotropic glutamate receptor complex;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0032983|kainate selective glutamate receptor complex;GO:0042734|presynaptic membrane;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0043235|receptor complex;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0098978|glutamatergic synapse;GO:0099056|integral component of presynaptic membrane;","GO:0004970|ionotropic glutamate receptor activity;GO:0005234|extracellularly glutamate-gated ion channel activity;GO:0005313|L-glutamate transmembrane transporter activity;GO:0005515|protein binding;GO:0008066|glutamate receptor activity;GO:0015276|ligand-gated ion channel activity;GO:0015277|kainate selective glutamate receptor activity;GO:0016595|glutamate binding;GO:0038023|signaling receptor activity;GO:0042802|identical protein binding;GO:1901363|heterocyclic compound binding;GO:1904315|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K05201","GRIK1; glutamate receptor, ionotropic kainate 1"]
["ENSRNOG00000004713",3,0.192991315,11,0.710180456,0.271749684,-1.879649737,0.027238164,0.013451413,"down","yes","Kcnj16","protein_coding","chr10:95960725-96021702:+","gi|51592082|ref|NP_445766.2|",2271,0,"inward rectifier potassium channel 16 [Rattus norvegicus]","gi|672069710|ref|XM_006247570.2|",3480,0,"PREDICTED: Rattus norvegicus potassium inwardly-rectifying channel, subfamily J, member 16 (Kcnj16), transcript variant X3, mRNA","P52191",878,0,"Inward rectifier potassium channel 16",".",".",".",".","pfam01007","IRK","Inward rectifier potassium channel.","GO:0006813|potassium ion transport;GO:0006885|regulation of pH;GO:0010037|response to carbon dioxide;GO:0034765|regulation of ion transmembrane transport;GO:0071805|potassium ion transmembrane transport;GO:1990573|potassium ion import across plasma membrane;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;","GO:0005242|inward rectifier potassium channel activity;GO:0005515|protein binding;","K05009","KCNJ16, KIR5.1; potassium inwardly-rectifying channel subfamily J member 16"]
["ENSRNOG00000005929",3,0.192991315,11,0.710180456,0.271749684,-1.879649737,0.027238164,0.013451413,"down","yes","Them6","protein_coding","chr7:106606570-106609746:+","gi|56090359|ref|NP_001007659.1|",980,{"v":9e-128,"d":"9.00E-128"},"protein THEM6 precursor [Rattus norvegicus]","gi|56090358|ref|NM_001007658.1|",1541,0,"Rattus norvegicus thioesterase superfamily member 6 (Them6), mRNA","Q5XIE1",382,{"v":3e-129,"d":"3.00E-129"},"Protein THEM6",".",".",".",".","pfam13279","4HBT_2","Thioesterase-like superfamily. This family contains a wide variety of enzymes, principally thioesterases. These enzymes are part of the Hotdog fold superfamily.","GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005576|extracellular region;","GO:0003674|molecular_function;",".","."]
["ENSRNOG00000020614",3,0.192991315,11,0.710180456,0.271749684,-1.879649737,0.027238164,0.013451413,"down","yes","Phlda2","protein_coding","chr1:198696897-198697836:-","gi|672039228|ref|XP_008758317.1|",766,{"v":8e-100,"d":"8.00E-100"},"PREDICTED: pleckstrin homology-like domain family A member 2 isoform X1 [Rattus norvegicus]","gi|282165683|ref|NM_001100521.1|",705,0,"Rattus norvegicus pleckstrin homology-like domain, family A, member 2 (Phlda2), transcript variant 1, mRNA","O08969",248,{"v":5e-82,"d":"5.00E-82"},"Pleckstrin homology-like domain family A member 2",".",".",".",".","pfam00169","PH","PH domain. PH stands for pleckstrin homology.","GO:0001890|placenta development;GO:0009887|animal organ morphogenesis;GO:0010468|regulation of gene expression;GO:0030334|regulation of cell migration;GO:0043065|positive regulation of apoptotic process;GO:0045995|regulation of embryonic development;GO:0060721|regulation of spongiotrophoblast cell proliferation;GO:0070873|regulation of glycogen metabolic process;GO:1903547|regulation of growth hormone activity;","GO:0005737|cytoplasm;","GO:1901981|phosphatidylinositol phosphate binding;","K23793","PHLDA; pleckstrin homology-like domain family A"]
["ENSRNOG00000050425",3,0.192991315,11,0.710180456,0.271749684,-1.879649737,0.027238164,0.013451413,"down","yes","RGD1561777","protein_coding","chr20:43371903-43394510:-","gi|672031857|ref|XP_008773211.1|",1761,0,"PREDICTED: sodium-dependent glucose transporter 1C [Rattus norvegicus]","gi|672031856|ref|XM_008774989.1|",1207,0,"PREDICTED: Rattus norvegicus similar to Na+ dependent glucose transporter 1 (RGD1561777), transcript variant X1, mRNA","Q8VCV9",587,0,"Sodium-dependent glucose transporter 1A",".",".",".",".","pfam07690","MFS_1","Major Facilitator Superfamily.","GO:1904659|glucose transmembrane transport;","GO:0016021|integral component of membrane;","GO:0005355|glucose transmembrane transporter activity;","K08175","NAGLT1; MFS transporter, FHS family, Na+ dependent glucose transporter 1"]
["ENSRNOG00000000889",2,0.128660876,9,0.581056737,0.221425668,-2.175105621,0.028100263,0.013837671,"down","yes","AABR07011057.1","protein_coding","chr12:4201359-4238722:-","gi|183986042|gb|AAI66500.1|",5513,0,"LOC304239 protein [Rattus norvegicus]","gi|183986041|gb|BC166500.1|",3735,0,"Rattus norvegicus similar to RalA binding protein 1, mRNA (cDNA clone IMAGE:7115612), partial cds","Q62796",858,0,"RalA-binding protein 1",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.",".",".",".",".","."]
["ENSRNOG00000004704",2,0.128660876,9,0.581056737,0.221425668,-2.175105621,0.028100263,0.013837671,"down","yes","Dcstamp","protein_coding","chr7:70807581-70822078:+","gi|392341599|ref|XP_001062083.3|",2188,0,"PREDICTED: dendritic cell-specific transmembrane protein isoform X2 [Rattus norvegicus]","gi|672021819|ref|XM_001062083.5|",1952,0,"PREDICTED: Rattus norvegicus dendritic cell-specific transmembrane protein (LOC103690326), transcript variant X2, mRNA","Q7TNJ0",739,0,"Dendritic cell-specific transmembrane protein",".",".",".",".","pfam07782","DC_STAMP","DC-STAMP-like protein. This is a family of sequences which are similar to a region of the dendritic cell-specific transmembrane protein (DC-STAMP). This is thought to be a novel receptor protein that shares no identity with other multimembrane-spanning proteins. It is thought to have seven putative transmembrane regions, two of which are found in the region featured in this family. DC-STAMP is also described as having potential N-linked glycosylation sites and a potential phosphorylation site for PKC, but these are not conserved throughout the family.","GO:0030308|negative regulation of cell growth;GO:0030316|osteoclast differentiation;GO:0034241|positive regulation of macrophage fusion;GO:0036006|cellular response to macrophage colony-stimulating factor stimulus;GO:0043011|myeloid dendritic cell differentiation;GO:0045657|positive regulation of monocyte differentiation;GO:0045780|positive regulation of bone resorption;GO:0061025|membrane fusion;GO:0071353|cellular response to interleukin-4;GO:0071356|cellular response to tumor necrosis factor;GO:0072675|osteoclast fusion;","GO:0005789|endoplasmic reticulum membrane;GO:0009986|cell surface;GO:0010008|endosome membrane;GO:0016021|integral component of membrane;GO:0030176|integral component of endoplasmic reticulum membrane;",".",".","."]
["ENSRNOG00000010535",2,0.128660876,9,0.581056737,0.221425668,-2.175105621,0.028100263,0.013837671,"down","yes","Cdh18","protein_coding","chr2:73345005-73820138:+","gi|145587090|ref|NP_001074768.1|",3922,0,"cadherin-18 precursor [Mus musculus]","gi|672015521|ref|XM_008775091.1|",2895,0,"PREDICTED: Rattus norvegicus cadherin 18, type 2 (Cdh18), mRNA","Q13634",1479,0,"Cadherin-18",".",".",".",".","pfam01049","Cadherin_C","Cadherin cytoplasmic region. Cadherins are vital in cell-cell adhesion during tissue differentiation. Cadherins are linked to the cytoskeleton by catenins. Catenins bind to the cytoplasmic tail of the cadherin. Cadherins cluster to form foci of homophilic binding units. A key determinant to the strength of the binding that it is mediated by cadherins is the juxtamembrane region of the cadherin. This region induces clustering and also binds to the protein p120ctn.","GO:0000902|cell morphogenesis;GO:0007043|cell-cell junction assembly;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007275|multicellular organism development;GO:0016339|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0034332|adherens junction organization;GO:0098742|cell-cell adhesion via plasma-membrane adhesion molecules;","GO:0005912|adherens junction;GO:0016021|integral component of membrane;GO:0016342|catenin complex;","GO:0005509|calcium ion binding;GO:0045296|cadherin binding;","K06805","CDH18; cadherin 18, type 2"]
["ENSRNOG00000018701",2,0.128660876,9,0.581056737,0.221425668,-2.175105621,0.028100263,0.013837671,"down","yes","Tpsg1","protein_coding","chr10:14386352-14390258:+","gi|28212252|ref|NP_783183.1|",1373,0,"tryptase gamma precursor [Rattus norvegicus]","gi|31342208|ref|NM_175593.2|",1065,0,"Rattus norvegicus tryptase gamma 1 (Tpsg1), mRNA","Q9QUL7",473,{"v":7e-166,"d":"7.00E-166"},"Tryptase gamma","VC1649",108,{"v":7e-25,"d":"7.00E-25"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;","GO:0005615|extracellular space;GO:0016021|integral component of membrane;","GO:0004252|serine-type endopeptidase activity;","K09615","TPSG1; tryptase gamma 1 [EC:3.4.21.-]"]
["ENSRNOG00000021123",2,0.128660876,9,0.581056737,0.221425668,-2.175105621,0.028100263,0.013837671,"down","yes","AC098622.1","protein_coding","chr1:204055499-204077329:+","gi|674059777|ref|XP_008836516.1|",328,{"v":2E-35,"d":"2.00E-35"},"PREDICTED: ATP synthase F(0) complex subunit C1, mitochondrial [Nannospalax galili]","gi|672068534|ref|XM_006247188.2|",258,{"v":6e-131,"d":"6.00E-131"},"PREDICTED: Rattus norvegicus ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9) (Atp5g1), transcript variant X1, mRNA","Q06645",129,{"v":2e-36,"d":"2.00E-36"},"ATP synthase F(0) complex subunit C1, mitochondrial","Q0130",59.3,{"v":3E-11,"d":"3.00E-11"},"COG0636","pfam00137","ATP-synt_C","ATP synthase subunit C.",".",".",".",".","."]
["ENSRNOG00000025501",2,0.128660876,9,0.581056737,0.221425668,-2.175105621,0.028100263,0.013837671,"down","yes","Snx31","protein_coding","chr7:67676524-67732086:-","gi|392349465|ref|XP_003750386.1|",2351,0,"PREDICTED: LOW QUALITY PROTEIN: sorting nexin-31 isoform X2 [Rattus norvegicus]","gi|672059068|ref|XM_003750338.3|",1785,0,"PREDICTED: Rattus norvegicus sorting nexin 31 (Snx31), transcript variant X2, mRNA","Q6P8Y7",818,0,"Sorting nexin-31",".",".",".",".","pfam00787","PX","PX domain. PX domains bind to phosphoinositides.","GO:0006886|intracellular protein transport;","GO:0005769|early endosome;GO:0032991|protein-containing complex;","GO:0035091|phosphatidylinositol binding;","K17937","SNX31; sorting nexin-31"]
["ENSRNOG00000026740",2,0.128660876,9,0.581056737,0.221425668,-2.175105621,0.028100263,0.013837671,"down","yes","ENSRNOG00000026740","protein_coding","chr16:75975463-75987628:+","gi|81295333|ref|NP_001032259.1|",1233,{"v":2e-166,"d":"2.00E-166"},"uncharacterized protein LOC290876 [Rattus norvegicus]","gi|81295332|ref|NM_001037182.1|",1351,0,"Rattus norvegicus similar to RIKEN cDNA 1700029H14 (LOC290876), mRNA",".",".",".",".",".",".",".",".","pfam05793","TFIIF_alpha","Transcription initiation factor IIF, alpha subunit (TFIIF-alpha). Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) or RNA polymerase II-associating protein 74 (RAP74) is the large subunit of transcription factor IIF (TFIIF), which is essential for accurate initiation and stimulates elongation by RNA polymerase II.",".",".",".",".","."]
["ENSRNOG00000043390",2,0.128660876,9,0.581056737,0.221425668,-2.175105621,0.028100263,0.013837671,"down","yes","ENSRNOG00000043390","protein_coding","chr7:84768254-85271766:-","gi|149066394|gb|EDM16267.1|",813,{"v":9E-103,"d":"9.00E-103"},"similar to sterile alpha motif domain containing 12 (predicted), isoform CRA_a [Rattus norvegicus]","gi|32362316|gb|AC115452.4|",1028,0,"Rattus norvegicus 7 BAC CH230-309G3 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam07647","SAM_2","SAM domain (Sterile alpha motif).","GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;","GO:0009898|cytoplasmic side of plasma membrane;",".",".","."]
["ENSRNOG00000050211",2,0.128660876,9,0.581056737,0.221425668,-2.175105621,0.028100263,0.013837671,"down","yes","AABR07018273.2","pseudogene","chr15:43411907-43412509:-","gi|837795987|ref|XP_012781307.1|",891,{"v":1e-118,"d":"1.00E-118"},"PREDICTED: WD repeat-containing protein 82 [Ochotona princeps]","gi|404351674|ref|NM_001271306.1|",377,0,"Rattus norvegicus WD repeat domain 82 (Wdr82), mRNA","Q8BFQ4",347,{"v":4e-119,"d":"4.00E-119"},"WD repeat-containing protein 82",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.",".",".",".",".","."]
["ENSRNOG00000059914",2,0.128660876,9,0.581056737,0.221425668,-2.175105621,0.028100263,0.013837671,"down","yes","U2","snRNA","chr5:73842855-73843025:-",".",".",".",".","gi|354799963|gb|JN964464.1|",61,{"v":5e-22,"d":"5.00E-22"},"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Clip1:tm1e(EUCOMM)Hmgu; transgenic",".",".",".",".",".",".",".",".","pfam15216","TSLP","Thymic stromal lymphopoietin.",".",".",".",".","."]
["ENSRNOG00000063116",2,0.128660876,9,0.581056737,0.221425668,-2.175105621,0.028100263,0.013837671,"down","yes","ENSRNOG00000063116","snoRNA","chr7:129676333-129676469:-","gi|674056928|ref|XP_008834972.1|",141,6E-9,"PREDICTED: DNA-directed RNA polymerase I subunit RPA1 isoform X2 [Nannospalax galili]","gi|291327552|gb|AC142003.2|",127,{"v":8e-59,"d":"8.00E-59"},"Rattus norvegicus BAC CH230-241B5 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam05280","FlhC","Flagellar transcriptional activator (FlhC). This family consists of several bacterial flagellar transcriptional activator (FlhC) proteins. FlhC combines with FlhD to form a regulatory complex in Escherichia coli, this complex has been shown to be a global regulator involved in many cellular processes as well as a flagellar transcriptional activator.",".",".",".",".","."]
["ENSRNOG00000067697",2,0.128660876,9,0.581056737,0.221425668,-2.175105621,0.028100263,0.013837671,"down","yes","ENSRNOG00000067697","lncRNA","chr20:3561235-3564816:-",".",".",".",".","gi|110350025|gb|AC130591.5|",127,{"v":3e-58,"d":"3.00E-58"},"Rattus norvegicus BAC CH230-312A21 () complete sequence",".",".",".",".",".",".",".",".","pfam03808","Glyco_tran_WecB","Glycosyl transferase WecB/TagA/CpsF family.",".",".",".",".","."]
["ENSRNOG00000069031",2,0.128660876,9,0.581056737,0.221425668,-2.175105621,0.028100263,0.013837671,"down","yes","ENSRNOG00000069031","lncRNA","chr2:144639258-144657285:+",".",".",".",".","gi|298890061|emb|FQ230606.1|",1100,0,"Rattus norvegicus TL0AEA8YM05 mRNA sequence",".",".",".",".",".",".",".",".","pfam10318","7TM_GPCR_Srh","Serpentine type 7TM GPCR chemoreceptor Srh. Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.",".",".",".",".","."]
["ENSRNOG00000001117",14,0.900626135,28,1.80773207,0.498207754,-1.005180619,0.028366329,0.013955456,"down","yes","Fbxl18","protein_coding","chr12:11676115-11699181:+","gi|568938701|ref|XP_006504756.1|",3656,0,"PREDICTED: F-box/LRR-repeat protein 18 isoform X1 [Mus musculus]","gi|672072297|ref|XM_006248907.2|",2760,0,"PREDICTED: Rattus norvegicus F-box and leucine-rich repeat protein 18 (Fbxl18), transcript variant X3, mRNA","Q96ME1",1127,0,"F-box/LRR-repeat protein 18",".",".",".",".","pfam12937","F-box-like","F-box-like. This is an F-box-like family.","GO:0031146|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;","GO:0019005|SCF ubiquitin ligase complex;",".","K10284","FBXL18; F-box and leucine-rich repeat protein 18"]
["ENSRNOG00000049642",14,0.900626135,28,1.80773207,0.498207754,-1.005180619,0.028366329,0.013955456,"down","yes","Smim5","protein_coding","chr10:101134033-101139813:+","gi|817278049|ref|XP_012309130.1|",218,{"v":1e-18,"d":"1.00E-18"},"PREDICTED: small integral membrane protein 5 isoform X1 [Aotus nancymaae]","gi|478246974|ref|NM_001277479.1|",1049,0,"Rattus norvegicus small integral membrane protein 5 (Smim5), transcript variant 1, mRNA","Q71RC9",85.1,{"v":3e-19,"d":"3.00E-19"},"Small integral membrane protein 5",".",".",".",".","pfam04770","ZF-HD_dimer","ZF-HD protein dimerization region. This family of proteins has are plant transcription factors, and have been named ZF-HD for zinc finger homeodomain proteins, on the basis of similarity to proteins of known structure. This region is thought to be involved in the formation of homo and heterodimers, and may form a zinc finger.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000010839",6,0.385982629,16,1.032989754,0.373655815,-1.420218119,0.029340399,0.014392519,"down","yes","Krt222","protein_coding","chr10:84186173-84196015:-","gi|109491832|ref|XP_001081416.1|",1283,{"v":1E-172,"d":"1.00E-172"},"PREDICTED: keratin-like protein KRT222 isoform X1 [Rattus norvegicus]","gi|672025227|ref|XM_001081416.5|",966,0,"PREDICTED: Rattus norvegicus keratin 222 (Krt222), transcript variant X1, mRNA","Q8CCX5",475,{"v":4E-165,"d":"4.00E-165"},"Keratin-like protein KRT222",".",".",".",".","pfam00038","Filament","Intermediate filament protein.",".","GO:0005882|intermediate filament;","GO:0005198|structural molecule activity;",".","."]
["ENSRNOG00000012404",6,0.385982629,16,1.032989754,0.373655815,-1.420218119,0.029340399,0.014392519,"down","yes","Thrsp","protein_coding","chr1:151723086-151728075:-","gi|149068933|gb|EDM18485.1|",507,{"v":7e-70,"d":"7.00E-70"},"thyroid hormone responsive protein, isoform CRA_b [Rattus norvegicus]","gi|207047|gb|K01934.1|RATSPOT14",1510,0,"Rat hepatic product spot 14, gene and flanks","P04143",199,{"v":2e-58,"d":"2.00E-58"},"Thyroid hormone-inducible hepatic protein",".",".",".",".","pfam07084","Spot_14","Thyroid hormone-inducible hepatic protein Spot 14. This family consists of several thyroid hormone-inducible hepatic protein (Spot 14 or S14) sequences. Mainly expressed in tissues that synthesize triglycerides, the mRNA coding for Spot 14 has been shown to be increased in rat liver by insulin, dietary carbohydrates, glucose in hepatocyte culture medium, as well as thyroid hormone. In contrast, dietary fats and polyunsaturated fatty acids, have been shown to decrease the amount of Spot 14 mRNA, while an elevated level of cAMP acts as a dominant negative factor. In addition, liver-specific factors or chromatin organisation of the gene have been shown to contribute to the regulation of its expression. Spot 14 protein is thought to be required for induction of hepatic lipogenesis.","GO:0006629|lipid metabolic process;GO:0009617|response to bacterium;GO:0010866|regulation of triglyceride biosynthetic process;GO:0046890|regulation of lipid biosynthetic process;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;",".","."]
["ENSRNOG00000061230",12,0.771965258,25,1.614046491,0.478279444,-1.064074308,0.029967651,0.014680035,"down","yes","L1cam","protein_coding","chrX:151597277-151623857:-","gi|672088986|ref|XP_008771859.1|",6397,0,"PREDICTED: neural cell adhesion molecule L1 isoform X3 [Rattus norvegicus]","gi|672088985|ref|XM_008773637.1|",5069,0,"PREDICTED: Rattus norvegicus L1 cell adhesion molecule (L1cam), transcript variant X3, mRNA","Q05695",2441,0,"Neural cell adhesion molecule L1",".",".",".",".","pfam13882","Bravo_FIGEY","Bravo-like intracellular region. This is the very C-terminal intracellular region of neural adhesion molecule L1 proteins that are also known as Bravo or NrCAM. It lies upstream of the IG and Fn3 domains and has the highly conserved motif FIGEY. The function is not known.","GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007159|leukocyte cell-cell adhesion;GO:0007160|cell-matrix adhesion;GO:0007166|cell surface receptor signaling pathway;GO:0007411|axon guidance;GO:0007413|axonal fasciculation;GO:0010811|positive regulation of cell-substrate adhesion;GO:0014823|response to activity;GO:0016477|cell migration;GO:0022409|positive regulation of cell-cell adhesion;GO:0030182|neuron differentiation;GO:0031175|neuron projection development;GO:0033631|cell-cell adhesion mediated by integrin;GO:0034109|homotypic cell-cell adhesion;GO:0045773|positive regulation of axon extension;GO:0050804|modulation of chemical synaptic transmission;GO:0050808|synapse organization;GO:0050850|positive regulation of calcium-mediated signaling;GO:0061564|axon development;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:0071361|cellular response to ethanol;GO:0071542|dopaminergic neuron differentiation;GO:0071549|cellular response to dexamethasone stimulus;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0097066|response to thyroid hormone;GO:0097069|cellular response to thyroxine stimulus;GO:1990090|cellular response to nerve growth factor stimulus;","GO:0005768|endosome;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0042734|presynaptic membrane;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0044294|dendritic growth cone;GO:0044295|axonal growth cone;GO:0045121|membrane raft;GO:0098685|Schaffer collateral - CA1 synapse;","GO:0005178|integrin binding;GO:0005515|protein binding;GO:0008046|axon guidance receptor activity;GO:0019904|protein domain specific binding;GO:0030165|PDZ domain binding;GO:0033691|sialic acid binding;GO:0042802|identical protein binding;GO:0043621|protein self-association;","K06550","L1CAM, CD171; L1 cell adhesion molecule"]
["ENSRNOG00000050767",10,0.643304382,22,1.420360912,0.45291614,-1.142684143,0.031008471,0.015161286,"down","yes","Nrn1","protein_coding","chr17:28129977-28138896:+","gi|556752844|ref|XP_005971807.1|",567,{"v":1e-65,"d":"1.00E-65"},"PREDICTED: neuritin [Pantholops hodgsonii]","gi|16758969|ref|NM_053346.1|",1571,0,"Rattus norvegicus neuritin 1 (Nrn1), mRNA","O08957",218,{"v":9e-67,"d":"9.00E-67"},"Neuritin",".",".",".",".","pfam15056","NRN1","Neuritin protein family. The domain family Neuritin1 (NRN1) is a GPI-anchored protein expressed in post-mitotic-differentiating neurons in the developing nervous system. NRN1 is a glutamate and neurotrophin receptor target encoding a neuronal protein that functions extracellularly to modulate neurite outgrowth (OMIM:607409).   This family of proteins is found in eukaryotes. Proteins in this family are typically between and 158 amino acids in length.","GO:0007399|nervous system development;GO:1990138|neuron projection extension;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0005615|extracellular space;GO:0016020|membrane;GO:0032281|AMPA glutamate receptor complex;GO:0046658|anchored component of plasma membrane;GO:0098978|glutamatergic synapse;","GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000017412",8,0.514643505,19,1.226675333,0.419543372,-1.253108133,0.031040396,0.015175596,"down","yes","AABR07001512.1","protein_coding","chr1:48369044-48369595:-","gi|94400930|ref|NP_001035361.1|",581,{"v":6e-74,"d":"6.00E-74"},"deoxyuridine 5'-triphosphate nucleotidohydrolase isoform 2 [Rattus norvegicus]","gi|346227228|ref|NG_027937.2|",346,{"v":5e-180,"d":"5.00E-180"},"Rattus norvegicus deoxyuridine triphosphatase pseudogene (Dut-ps) on chromosome 1","P70583",229,{"v":3e-75,"d":"3.00E-75"},"Deoxyuridine 5'-triphosphate nucleotidohydrolase","SPAC644.05c",132,{"v":8e-39,"d":"8.00E-39"},"COG0756","pfam00692","dUTPase","dUTPase. dUTPase hydrolyses dUTP to dUMP and pyrophosphate.",".",".",".",".","."]
["ENSRNOG00000018949",5,0.321652191,14,0.903866035,0.355862681,-1.490607447,0.034580271,0.016774132,"down","yes","Dlk2","protein_coding","chr9:14676562-14681594:-","gi|672064328|ref|XP_008765087.1|",1869,0,"PREDICTED: protein delta homolog 2 isoform X2 [Rattus norvegicus]","gi|672064327|ref|XM_008766865.1|",1664,0,"PREDICTED: Rattus norvegicus delta-like 2 homolog (Drosophila) (Dlk2), transcript variant X2, mRNA","D3ZUK3",672,0,"Protein delta homolog 2",".",".",".",".","pfam00008","EGF","EGF-like domain. There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.","GO:0045598|regulation of fat cell differentiation;GO:0045746|negative regulation of Notch signaling pathway;","GO:0016021|integral component of membrane;","GO:0005112|Notch binding;GO:0005509|calcium ion binding;GO:0042802|identical protein binding;","K24462","DLK2, EGFL9; protein delta homolog 2"]
["ENSRNOG00000047505",5,0.321652191,14,0.903866035,0.355862681,-1.490607447,0.034580271,0.016774132,"down","yes","Tubb4a","protein_coding","chr9:1917845-1925291:-","gi|537154773|gb|ERE72810.1|",2217,0,"DENN domain-containing protein 1C-like protein [Cricetulus griseus]","gi|195539899|gb|BC168216.1|",2082,0,"Rattus norvegicus tubulin, beta 4, mRNA (cDNA clone MGC:188186 IMAGE:7315263), complete cds","Q9D6F9",856,0,"Tubulin beta-4A chain","ECU03g0820i",734,0,"COG5023","pfam03953","Tubulin_C","Tubulin C-terminal domain. This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).","GO:0000226|microtubule cytoskeleton organization;GO:0000278|mitotic cell cycle;GO:0031115|negative regulation of microtubule polymerization;","GO:0005737|cytoplasm;GO:0005874|microtubule;GO:0005929|cilium;GO:0005930|axoneme;GO:0033269|internode region of axon;GO:0042995|cell projection;GO:0043025|neuronal cell body;GO:0043209|myelin sheath;","GO:0003924|GTPase activity;GO:0005200|structural constituent of cytoskeleton;GO:0005509|calcium ion binding;GO:0005525|GTP binding;","K07375","TUBB; tubulin beta"]
["ENSRNOG00000066323",5,0.321652191,14,0.903866035,0.355862681,-1.490607447,0.034580271,0.016774132,"down","yes","ENSRNOG00000066323","lncRNA","chr10:37449202-37450311:+","gi|148701441|gb|EDL33388.1|",233,{"v":7e-21,"d":"7.00E-21"},"mCG1045525, partial [Mus musculus]","gi|86439996|gb|AC129342.5|",181,{"v":8e-88,"d":"8.00E-88"},"Rattus norvegicus BAC CH230-229B21 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P46935",51.6,9e-06,"E3 ubiquitin-protein ligase NEDD4",".",".",".",".","pfam12749","Metallothio_Euk","Eukaryotic metallothionein. This is a family of eukaryotic metallothioneins.",".",".",".",".","."]
["ENSRNOG00000068090",5,0.321652191,14,0.903866035,0.355862681,-1.490607447,0.034580271,0.016774132,"down","yes","U6","snRNA","chr4:24952724-24952824:+",".",".",".",".","gi|298914334|emb|FQ225963.1|",101,{"v":1e-44,"d":"1.00E-44"},"Rattus norvegicus TL0AEA3YI18 mRNA sequence",".",".",".",".",".",".",".",".","pfam00902","TatC","Sec-independent protein translocase protein (TatC). The bacterial Tat system has a remarkable ability to transport folded proteins even enzyme complexes across the cytoplasmic membrane. It is structurally and mechanistically similar to the Delta pH-driven thylakoidal protein import pathway. A functional Tat system or Delta pH-dependent pathway requires three integral membrane proteins: TatA/Tha4, TatB/Hcf106 and TatC/cpTatC. The TatC protein is essential for the function of both pathways. It might be involved in twin-arginine signal peptide recognition, protein translocation and proton translocation. Sequence analysis predicts that TatC contains six transmembrane helices (TMHs), and experimental data confirmed that N- and C-termini of TatC or cpTatC are exposed to the cytoplasmic or stromal face of the membrane. The cytoplasmic N-terminus and the first cytoplasmic loop region of the Escherichia coli TatC protein are essential for protein export. At least two TatC molecules co-exist within each Tat translocon.",".",".",".",".","."]
["ENSRNOG00000068806",5,0.321652191,14,0.903866035,0.355862681,-1.490607447,0.034580271,0.016774132,"down","yes","Sdr42e2","protein_coding","chr1:175362150-175382050:+","gi|672038289|ref|XP_008758057.1|",1778,0,"PREDICTED: putative short-chain dehydrogenase/reductase family 42E member 2 isoform X2 [Rattus norvegicus]","gi|672038288|ref|XM_008759835.1|",1179,0,"PREDICTED: Rattus norvegicus short chain dehydrogenase/reductase family 42E, member 2 (Sdr42e2), transcript variant X2, mRNA","A6NKP2",605,0,"Putative short-chain dehydrogenase/reductase family 42E member 2","ML1942",132,{"v":1e-33,"d":"1.00E-33"},"COG0451","pfam01073","3Beta_HSD","3-beta hydroxysteroid dehydrogenase/isomerase family. The enzyme 3 beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase (3 beta-HSD) catalyses the oxidation and isomerization of 5-ene-3 beta-hydroxypregnene and 5-ene-hydroxyandrostene steroid precursors into the corresponding 4-ene-ketosteroids necessary for the formation of all classes of steroid hormones.",".",".",".",".","."]
["ENSRNOG00000002866",13,0.836295696,26,1.678608351,0.498207754,-1.005180619,0.03464874,0.01679982,"down","yes","Rassf6","protein_coding","chr14:17442789-17473330:+","gi|672075760|ref|XP_008768258.1|",1889,0,"PREDICTED: ras association domain-containing protein 6 isoform X2 [Rattus norvegicus]","gi|672075766|ref|XM_006250747.2|",1867,0,"PREDICTED: Rattus norvegicus Ras association (RalGDS/AF-6) domain family member 6 (Rassf6), transcript variant X5, mRNA","Q4QR82",709,0,"Ras association domain-containing protein 6",".",".",".",".","pfam00788","RA","Ras association (RalGDS/AF-6) domain. RasGTP effectors (in cases of AF6, canoe and RalGDS); putative RasGTP effectors in other cases. Recent evidence (not yet in MEDLINE) shows that some RA domains do NOT bind RasGTP. Predicted structure similar to that determined, and that of the RasGTP-binding domain of Raf kinase.","GO:0006915|apoptotic process;GO:0007165|signal transduction;GO:0042981|regulation of apoptotic process;GO:0043065|positive regulation of apoptotic process;",".",".","K09854","RASSF6; Ras association domain-containing protein 6"]
["ENSRNOG00000003952",13,0.836295696,26,1.678608351,0.498207754,-1.005180619,0.03464874,0.01679982,"down","yes","AABR07020879.1","protein_coding","chr13:39300163-39343767:-","gi|564315712|ref|XP_002724908.2|",7681,0,"PREDICTED: mitogen-activated protein kinase kinase kinase 19 isoform X1 [Rattus norvegicus]","gi|672027069|ref|XM_002724862.3|",4852,0,"PREDICTED: Rattus norvegicus mitogen-activated protein kinase kinase kinase 19 (Map3k19), transcript variant X1, mRNA","E9Q3S4",2009,0,"Mitogen-activated protein kinase kinase kinase 19",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.",".",".",".",".","."]
["ENSRNOG00000010128",13,0.836295696,26,1.678608351,0.498207754,-1.005180619,0.03464874,0.01679982,"down","yes","Slc27a2","protein_coding","chr3:113804728-113842208:+","gi|51858584|gb|AAH81766.1|",3203,0,"Solute carrier family 27 (fatty acid transporter), member 2 [Rattus norvegicus]","gi|13929033|ref|NM_031736.1|",2925,0,"Rattus norvegicus solute carrier family 27 member 2 (Slc27a2), mRNA","P97524",1234,0,"Very long-chain acyl-CoA synthetase",".",".",".",".","pfam00501","AMP-binding","AMP-binding enzyme.","GO:0000038|very long-chain fatty acid metabolic process;GO:0001561|fatty acid alpha-oxidation;GO:0001676|long-chain fatty acid metabolic process;GO:0006635|fatty acid beta-oxidation;GO:0006699|bile acid biosynthetic process;GO:0015908|fatty acid transport;GO:0042760|very long-chain fatty acid catabolic process;GO:0044539|long-chain fatty acid import;GO:0097089|methyl-branched fatty acid metabolic process;","GO:0005777|peroxisome;GO:0005778|peroxisomal membrane;GO:0005779|integral component of peroxisomal membrane;GO:0005783|endoplasmic reticulum;GO:0005788|endoplasmic reticulum lumen;GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030176|integral component of endoplasmic reticulum membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0004467|long-chain fatty acid-CoA ligase activity;GO:0005324|long-chain fatty acid transporter activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0015245|fatty acid transmembrane transporter activity;GO:0019899|enzyme binding;GO:0031957|very long-chain fatty acid-CoA ligase activity;GO:0047676|arachidonate-CoA ligase activity;GO:0047747|cholate-CoA ligase activity;GO:0050197|phytanate-CoA ligase activity;GO:0070251|pristanate-CoA ligase activity;","K08746","SLC27A2, FACVL1, FATP2; solute carrier family 27 (fatty acid transporter), member 2 [EC:6.2.1.- 6.2.1.3]"]
["ENSRNOG00000064621",13,0.836295696,26,1.678608351,0.498207754,-1.005180619,0.03464874,0.01679982,"down","yes","ENSRNOG00000064621","pseudogene","chr10:36275559-36276041:-","gi|31560385|ref|NP_062621.2|",760,{"v":7e-101,"d":"7.00E-101"},"60S ribosomal protein L21 [Mus musculus]","gi|189163511|ref|NG_007893.1|",245,{"v":8e-124,"d":"8.00E-124"},"Rattus norvegicus ribosomal protein L21, pseudogene 1 (Rpl21-ps1) on chromosome 9","P49666",297,{"v":2e-102,"d":"2.00E-102"},"60S ribosomal protein L21","YBR191w",176,{"v":1e-55,"d":"1.00E-55"},"COG2139","pfam01157","Ribosomal_L21e","Ribosomal protein L21e.",".",".",".",".","."]
["ENSRNOG00000069992",13,0.836295696,26,1.678608351,0.498207754,-1.005180619,0.03464874,0.01679982,"down","yes","Sgpp2","protein_coding","chr9:79763284-79880457:+","gi|300796917|ref|NP_001178740.1|",1774,0,"sphingosine-1-phosphate phosphatase 2 [Rattus norvegicus]","gi|300796916|ref|NM_001191811.1|",1126,0,"Rattus norvegicus sphingosine-1-phosphate phosphatase 2 (Sgpp2), mRNA","Q810K3",664,0,"Sphingosine-1-phosphate phosphatase 2","YKR053c",76.3,{"v":3e-14,"d":"3.00E-14"},"COG0671","pfam01569","PAP2","PAP2 superfamily. This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidizing halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.",".",".",".",".","."]
["ENSRNOG00000070391",11,0.70763482,23,1.484922772,0.476546547,-1.069310957,0.036596666,0.017683155,"down","yes","ENSRNOG00000070391","protein_coding","chr5:57985355-57987537:+","gi|149045771|gb|EDL98771.1|",616,{"v":9e-74,"d":"9.00E-74"},"rCG54821 [Rattus norvegicus]","gi|289802994|ref|NR_033355.1|",482,0,"Mus musculus RIKEN cDNA 5430416O09 gene (5430416O09Rik), long non-coding RNA","A0A1B0GSZ0",142,{"v":3e-39,"d":"3.00E-39"},"Small regulatory polypeptide of amino acid response",".",".",".",".","pfam01055","Glyco_hydro_31","Glycosyl hydrolases family 31. Glycosyl hydrolases are key enzymes of carbohydrate metabolizm. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases.",".",".",".",".","."]
["ENSRNOG00000003741",7,0.450313067,17,1.097551614,0.410288739,-1.285288539,0.037466256,0.018060549,"down","yes","Nptx1","protein_coding","chr10:104811403-104820367:-","gi|950368630|dbj|BAT46540.1|",2105,0,"neuronal pentraxin 1 [Tokudaia muenninki]","gi|139947582|ref|NM_153735.2|",4804,0,"Rattus norvegicus neuronal pentraxin I (Nptx1), mRNA","P47971",815,0,"Neuronal pentraxin-1",".",".",".",".","pfam00354","Pentaxin","Pentaxin family. Pentaxins are also known as pentraxins.","GO:0006839|mitochondrial transport;GO:0035865|cellular response to potassium ion;GO:0043653|mitochondrial fragmentation involved in apoptotic process;GO:0060385|axonogenesis involved in innervation;GO:0071333|cellular response to glucose stimulus;GO:0098962|regulation of postsynaptic neurotransmitter receptor activity;GO:0099151|regulation of postsynaptic density assembly;GO:0099645|neurotransmitter receptor localization to postsynaptic specialization membrane;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005886|plasma membrane;GO:0030133|transport vesicle;GO:0043005|neuron projection;GO:0043083|synaptic cleft;GO:0098978|glutamatergic synapse;","GO:0046872|metal ion binding;","K25709","NPTX; neuronal pentraxin"]
["ENSRNOG00000026493",7,0.450313067,17,1.097551614,0.410288739,-1.285288539,0.037466256,0.018060549,"down","yes","Cdnf","protein_coding","chr17:74713564-74728639:-","gi|82830401|ref|NP_001032632.1|",999,{"v":2e-130,"d":"2.00E-130"},"cerebral dopamine neurotrophic factor precursor [Rattus norvegicus]","gi|82830400|ref|NM_001037543.1|",624,0,"Rattus norvegicus cerebral dopamine neurotrophic factor (Cdnf), mRNA","P0C5I0",389,{"v":5e-132,"d":"5.00E-132"},"Cerebral dopamine neurotrophic factor",".",".",".",".","pfam10208","Armet","Degradation arginine-rich protein for mis-folding. This is a family of small proteins of approximately 170 residues which contain four di-sulfide bridges that are highly conserved from nematodes to humans. Armet is a soluble protein resident in the endoplasmic reticulum and induced by ER stress. It appears to be involved with dealing with mis-folded proteins in the ER, thus in quality control of ER stress.","GO:0007165|signal transduction;GO:0031175|neuron projection development;GO:0071542|dopaminergic neuron differentiation;","GO:0005615|extracellular space;GO:0005783|endoplasmic reticulum;","GO:0008083|growth factor activity;",".","."]
["ENSRNOG00000027103",7,0.450313067,17,1.097551614,0.410288739,-1.285288539,0.037466256,0.018060549,"down","yes","Gpr151","protein_coding","chr18:34568907-34570301:-","gi|31745152|ref|NP_853664.1|",2058,0,"probable G-protein coupled receptor 151 [Rattus norvegicus]","gi|31795569|ref|NM_181633.2|",1389,0,"Rattus norvegicus G protein-coupled receptor 151 (Gpr151), mRNA","Q7TSN5",796,0,"Probable G-protein coupled receptor 151",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0010447|response to acidic pH;","GO:0005887|integral component of plasma membrane;","GO:0004930|G protein-coupled receptor activity;GO:0042802|identical protein binding;","K08435","GPR151; G protein-coupled receptor 151"]
["ENSRNOG00000039357",7,0.450313067,17,1.097551614,0.410288739,-1.285288539,0.037466256,0.018060549,"down","yes","Niban3","protein_coding","chr16:18307221-18318585:+","gi|261245027|ref|NP_001094378.1|",2375,0,"niban-like protein 2 [Rattus norvegicus]","gi|261245026|ref|NM_001100908.1|",2193,0,"Rattus norvegicus family with sequence similarity 129, member C (Fam129c), mRNA",".",".",".",".",".",".",".",".","pfam15449","Retinal","Retinal protein. This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.",".",".",".",".","."]
["ENSRNOG00000061247",7,0.450313067,17,1.097551614,0.410288739,-1.285288539,0.037466256,0.018060549,"down","yes","Deup1","protein_coding","chr8:12380302-12442199:-","gi|672060919|ref|XP_008764155.1|",3298,0,"PREDICTED: deuterosome protein 1 isoform X1 [Rattus norvegicus]","gi|672060920|ref|XM_008765934.1|",2718,0,"PREDICTED: Rattus norvegicus coiled-coil domain containing 67 (Ccdc67), transcript variant X2, mRNA","Q5U3Z6",1159,0,"Deuterosome assembly protein 1",".",".",".",".","pfam13868","Trichoplein","tumor suppressor, Mitostatin. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs).","GO:0007099|centriole replication;GO:0030030|cell projection organization;GO:0098535|de novo centriole assembly involved in multi-ciliated epithelial cell differentiation;GO:1903251|multi-ciliated epithelial cell differentiation;","GO:0005737|cytoplasm;GO:0005814|centriole;GO:0098536|deuterosome;","GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000071083",7,0.450313067,17,1.097551614,0.410288739,-1.285288539,0.037466256,0.018060549,"down","yes","ENSRNOG00000071083","lncRNA","chr18:67401174-67403609:-","gi|755562041|ref|XP_011245368.1|",291,{"v":1E-25,"d":"1.00E-25"},"PREDICTED: formin-like protein 5 [Mus musculus]","gi|30425565|gb|AC109037.6|",274,{"v":3e-139,"d":"3.00E-139"},"Rattus norvegicus 18 BAC CH230-178G23 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam10060","DUF2298","Uncharacterized membrane protein (DUF2298). This domain, found in various hypothetical bacterial proteins, has no known function.",".",".",".",".","."]
["ENSRNOG00000006170",9,0.578973944,20,1.291237193,0.448386979,-1.157183713,0.037759666,0.018192774,"down","yes","Bach2","protein_coding","chr5:46638317-46977877:+","gi|209364556|ref|NP_001129226.1|",4081,0,"transcription regulator protein BACH2 [Rattus norvegicus]","gi|209364555|ref|NM_001135754.1|",3754,0,"Rattus norvegicus BTB domain and CNC homolog 2 (Bach2), mRNA","P97303",1533,0,"Transcription regulator protein BACH2",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0051170|import into nucleus;GO:0090721|primary adaptive immune response involving T cells and B cells;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:1990837|sequence-specific double-stranded DNA binding;","K09042","BACH; transcription regulator BACH"]
["ENSRNOG00000015376",4,0.257321753,12,0.774742316,0.332138503,-1.59014312,0.040224754,0.019198466,"down","yes","Npas1","protein_coding","chr1:77167381-77186762:-","gi|157819069|ref|NP_001100949.1|",2206,0,"neuronal PAS domain-containing protein 1 [Rattus norvegicus]","gi|672035026|ref|XM_006228413.2|",1965,0,"PREDICTED: Rattus norvegicus neuronal PAS domain protein 1 (Npas1), transcript variant X1, mRNA","P97459",832,0,"Neuronal PAS domain-containing protein 1",".",".",".",".","pfam14598","PAS_11","PAS domain. This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001964|startle response;GO:0006357|regulation of transcription by RNA polymerase II;GO:0042711|maternal behavior;GO:0045892|negative regulation of transcription, DNA-templated;","GO:0005634|nucleus;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0046982|protein heterodimerization activity;","K09098","NPAS1_3; neuronal PAS domain-containing protein 1/3"]
["ENSRNOG00000020477",4,0.257321753,12,0.774742316,0.332138503,-1.59014312,0.040224754,0.019198466,"down","yes","AABR07005533.1","protein_coding","chr1:170721272-170722576:-","gi|66730382|ref|NP_001019432.1|",2316,0,"CCA tRNA nucleotidyltransferase 1, mitochondrial [Rattus norvegicus]","gi|672038236|ref|XR_590426.1|",1305,0,"PREDICTED: Rattus norvegicus CCA tRNA nucleotidyltransferase 1, mitochondrial-like (LOC100911093), transcript variant X3, misc_RNA","Q8K1J6",875,0,"CCA tRNA nucleotidyltransferase 1, mitochondrial","SMc02700",219,{"v":3E-65,"d":"3.00E-65"},"COG0617","pfam01743","PolyA_pol","Poly A polymerase head domain. This family includes nucleic acid independent RNA polymerases, such as Poly(A) polymerase, which adds the poly (A) tail to mRNA EC:2.7.7.19. This family also includes the tRNA nucleotidyltransferase that adds the CCA to the 3' of the tRNA EC:2.7.7.25. This family is part of the nucleotidyltransferase superfamily.",".",".",".",".","."]
["ENSRNOG00000022852",4,0.257321753,12,0.774742316,0.332138503,-1.59014312,0.040224754,0.019198466,"down","yes","Snx22","protein_coding","chr8:66609970-66612850:-","gi|564364315|ref|XP_006243367.1|",930,{"v":2e-124,"d":"2.00E-124"},"PREDICTED: sorting nexin-22 isoform X2 [Rattus norvegicus]","gi|672061932|ref|XM_006243305.2|",803,0,"PREDICTED: Rattus norvegicus sorting nexin 22 (Snx22), transcript variant X2, mRNA","Q96L94",287,{"v":5e-96,"d":"5.00E-96"},"Sorting nexin-22",".",".",".",".","pfam00787","PX","PX domain. PX domains bind to phosphoinositides.",".",".","GO:1901981|phosphatidylinositol phosphate binding;","K17941","SNX22_24; sorting nexin-22/24"]
["ENSRNOG00000024623",4,0.257321753,12,0.774742316,0.332138503,-1.59014312,0.040224754,0.019198466,"down","yes","RGD1309170","protein_coding","chr2:226693809-226722289:-","gi|564338995|ref|XP_006233449.1|",1621,0,"PREDICTED: uncharacterized protein C4orf17 homolog isoform X1 [Rattus norvegicus]","gi|197385492|ref|NM_001134579.1|",1577,0,"Rattus norvegicus similar to hypothetical protein DKFZp434G072 (RGD1309170), mRNA",".",".",".",".",".",".",".",".","pfam15256","SPATIAL","SPATIAL. SPATIAL (stromal protein associated with thymii and lymph node) proteins may be involved in spermatid differentiation.",".",".",".",".","."]
["ENSRNOG00000058983",4,0.257321753,12,0.774742316,0.332138503,-1.59014312,0.040224754,0.019198466,"down","yes","Gata5","protein_coding","chr3:167418565-167426751:-","gi|66730290|ref|NP_001019487.1|",1662,0,"transcription factor GATA-5 [Rattus norvegicus]","gi|66730289|ref|NM_001024316.1|",2085,0,"Rattus norvegicus GATA binding protein 5 (Gata5), mRNA","P97489",614,0,"Transcription factor GATA-5","SPCC1393.08",108,{"v":8e-24,"d":"8.00E-24"},"COG5641","pfam05349","GATA-N","GATA-type transcription activator, N-terminal. GATA transcription factors mediate cell differentiation in a diverse range of tissues. Mutation are often associated with certain congenital human disorders. The six classical vertebrate GATA proteins, GATA-1 to GATA-6, are highly homologous and have two tandem zinc fingers. The classical GATA transcription factors function transcription activators. In lower metazoans GATA proteins carry a single canonical zinc finger. This family represents the N-terminal domain of the family of GATA transcription activators.","GO:0003180|aortic valve morphogenesis;GO:0003274|endocardial cushion fusion;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0010614|negative regulation of cardiac muscle hypertrophy;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0035481|positive regulation of Notch signaling pathway involved in heart induction;GO:0045165|cell fate commitment;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048738|cardiac muscle tissue development;GO:0060575|intestinal epithelial cell differentiation;GO:0062000|positive regulation of cardiac endothelial to mesenchymal transition;GO:0071773|cellular response to BMP stimulus;GO:1901228|positive regulation of transcription from RNA polymerase II promoter involved in heart development;","GO:0000785|chromatin;GO:0005634|nucleus;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987|proximal promoter sequence-specific DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0008270|zinc ion binding;GO:1990837|sequence-specific double-stranded DNA binding;","K17896","GATA5; GATA-binding protein 5"]
["ENSRNOG00000069978",4,0.257321753,12,0.774742316,0.332138503,-1.59014312,0.040224754,0.019198466,"down","yes","ENSRNOG00000069978","lncRNA","chr10:44167681-44185997:+",".",".",".",".","gi|672024823|ref|XR_338639.2|",785,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102546363 (LOC102546363), transcript variant X3, ncRNA",".",".",".",".",".",".",".",".","pfam03040","CemA","CemA family. Members of this family are probable integral membrane proteins. Their molecular function is unknown. CemA proteins are found in the inner envelope membrane of chloroplasts but not in the thylakoid membrane. A cyanobacterial member of this family has been implicated in CO2 transport, but is probably not a CO2 transporter itself. They are predicted to be haem-binding however this has not been proven experimentally.",".",".",".",".","."]
["ENSRNOG00000001130",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","Nos1","protein_coding","chr12:38626714-38710945:-","gi|672072911|ref|XP_008767432.1|",7632,0,"PREDICTED: nitric oxide synthase, brain isoform X1 [Rattus norvegicus]","gi|672072910|ref|XM_008769210.1|",4594,0,"PREDICTED: Rattus norvegicus nitric oxide synthase 1, neuronal (Nos1), transcript variant X1, mRNA","P29476",2840,0,"Nitric oxide synthase, brain","BH0823",346,{"v":4e-106,"d":"4.00E-106"},"COG4362","pfam02898","NO_synthase","Nitric oxide synthase, oxygenase domain.","GO:0001666|response to hypoxia;GO:0002028|regulation of sodium ion transport;GO:0006527|arginine catabolic process;GO:0006809|nitric oxide biosynthetic process;GO:0006936|muscle contraction;GO:0006941|striated muscle contraction;GO:0007263|nitric oxide mediated signal transduction;GO:0007420|brain development;GO:0007565|female pregnancy;GO:0007568|aging;GO:0008016|regulation of heart contraction;GO:0008285|negative regulation of cell proliferation;GO:0009408|response to heat;GO:0009725|response to hormone;GO:0010243|response to organonitrogen compound;GO:0010288|response to lead ion;GO:0014070|response to organic cyclic compound;GO:0014823|response to activity;GO:0018119|peptidyl-cysteine S-nitrosylation;GO:0031284|positive regulation of guanylate cyclase activity;GO:0031667|response to nutrient levels;GO:0032496|response to lipopolysaccharide;GO:0033137|negative regulation of peptidyl-serine phosphorylation;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0033197|response to vitamin E;GO:0033555|multicellular organismal response to stress;GO:0034760|negative regulation of iron ion transmembrane transport;GO:0035066|positive regulation of histone acetylation;GO:0035094|response to nicotine;GO:0042178|xenobiotic catabolic process;GO:0042311|vasodilation;GO:0043066|negative regulation of apoptotic process;GO:0043267|negative regulation of potassium ion transport;GO:0043434|response to peptide hormone;GO:0043524|negative regulation of neuron apoptotic process;GO:0043627|response to estrogen;GO:0045184|establishment of protein localization;GO:0045471|response to ethanol;GO:0045776|negative regulation of blood pressure;GO:0045822|negative regulation of heart contraction;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045906|negative regulation of vasoconstriction;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046676|negative regulation of insulin secretion;GO:0048148|behavioral response to cocaine;GO:0050767|regulation of neurogenesis;GO:0051346|negative regulation of hydrolase activity;GO:0051481|negative regulation of cytosolic calcium ion concentration;GO:0051612|negative regulation of serotonin uptake;GO:0051926|negative regulation of calcium ion transport;GO:0051930|regulation of sensory perception of pain;GO:0061875|negative regulation of hepatic stellate cell contraction;GO:0071260|cellular response to mechanical stimulus;GO:0071363|cellular response to growth factor stimulus;GO:0071731|response to nitric oxide;GO:0071872|cellular response to epinephrine stimulus;GO:0098735|positive regulation of the force of heart contraction;GO:0098924|retrograde trans-synaptic signaling by nitric oxide;GO:0099163|synaptic signaling by nitric oxide;GO:0140196|positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process;GO:1900273|positive regulation of long-term synaptic potentiation;GO:1901216|positive regulation of neuron death;GO:1902307|positive regulation of sodium ion transmembrane transport;","GO:0001917|photoreceptor inner segment;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0005901|caveola;GO:0012506|vesicle membrane;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0016529|sarcoplasmic reticulum;GO:0030018|Z disc;GO:0030141|secretory granule;GO:0030315|T-tubule;GO:0030425|dendrite;GO:0031965|nuclear membrane;GO:0032991|protein-containing complex;GO:0033017|sarcoplasmic reticulum membrane;GO:0042383|sarcolemma;GO:0042582|azurophil granule;GO:0043197|dendritic spine;GO:0043204|perikaryon;GO:0044305|calyx of Held;GO:0044306|neuron projection terminus;GO:0045121|membrane raft;GO:0045202|synapse;GO:0048471|perinuclear region of cytoplasm;GO:0071944|cell periphery;GO:0098978|glutamatergic synapse;GO:0099091|postsynaptic specialization, intracellular component;GO:0099092|postsynaptic density, intracellular component;","GO:0004517|nitric-oxide synthase activity;GO:0005515|protein binding;GO:0005516|calmodulin binding;GO:0008270|zinc ion binding;GO:0010181|FMN binding;GO:0016491|oxidoreductase activity;GO:0017080|sodium channel regulator activity;GO:0019899|enzyme binding;GO:0020037|heme binding;GO:0042802|identical protein binding;GO:0044325|ion channel binding;GO:0046870|cadmium ion binding;GO:0046872|metal ion binding;GO:0048306|calcium-dependent protein binding;GO:0050660|flavin adenine dinucleotide binding;GO:0050661|NADP binding;GO:0051117|ATPase binding;GO:0051219|phosphoprotein binding;GO:0070402|NADPH binding;GO:0097110|scaffold protein binding;","K13240","NOS1; nitric-oxide synthase, brain [EC:1.14.13.39]"]
["ENSRNOG00000002906",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","Nr1i2","protein_coding","chr11:62460213-62496658:+","gi|16418481|ref|NP_443212.1|",2312,0,"nuclear receptor subfamily 1 group I member 2 [Rattus norvegicus]","gi|148536881|ref|NM_052980.2|",2335,0,"Rattus norvegicus nuclear receptor subfamily 1, group I, member 2 (Nr1i2), mRNA","Q9R1A7",895,0,"Nuclear receptor subfamily 1 group I member 2",".",".",".",".","pfam00105","zf-C4","Zinc finger, C4 type (two domains). In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006355|regulation of transcription, DNA-templated;GO:0006805|xenobiotic metabolic process;GO:0010628|positive regulation of gene expression;GO:0030154|cell differentiation;GO:0030522|intracellular receptor signaling pathway;GO:0042178|xenobiotic catabolic process;GO:0042908|xenobiotic transport;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0016604|nuclear body;GO:0045111|intermediate filament cytoskeleton;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0004879|nuclear receptor activity;GO:0008270|zinc ion binding;GO:0016922|nuclear receptor binding;GO:1990837|sequence-specific double-stranded DNA binding;","K08540","NR1I2, PXR; pregnane X receptor"]
["ENSRNOG00000004890",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","Adcy8","protein_coding","chr7:96417324-96665911:-","gi|149066295|gb|EDM16168.1|",6262,0,"adenylate cyclase 8, isoform CRA_a [Rattus norvegicus]","gi|8392851|ref|NM_017142.1|",4566,0,"Rattus norvegicus adenylate cyclase 8 (brain) (Adcy8), mRNA","P40146",2415,0,"Adenylate cyclase type 8","all0661",154,{"v":2e-38,"d":"2.00E-38"},"COG2114","pfam00211","Guanylate_cyc","Adenylate and Guanylate cyclase catalytic domain.","GO:0006171|cAMP biosynthetic process;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007613|memory;GO:0007616|long-term memory;GO:0007626|locomotory behavior;GO:0010255|glucose mediated signaling pathway;GO:0014070|response to organic cyclic compound;GO:0019933|cAMP-mediated signaling;GO:0031915|positive regulation of synaptic plasticity;GO:0032793|positive regulation of CREB transcription factor activity;GO:0034199|activation of protein kinase A activity;GO:0035556|intracellular signal transduction;GO:0035774|positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0038003|opioid receptor signaling pathway;GO:0042593|glucose homeostasis;GO:0050804|modulation of chemical synaptic transmission;GO:0051259|protein complex oligomerization;GO:0051260|protein homooligomerization;GO:0051480|regulation of cytosolic calcium ion concentration;GO:0071277|cellular response to calcium ion;GO:0071315|cellular response to morphine;GO:0071333|cellular response to glucose stimulus;GO:0071377|cellular response to glucagon stimulus;GO:0080135|regulation of cellular response to stress;GO:0150076|neuroinflammatory response;GO:1900273|positive regulation of long-term synaptic potentiation;GO:1900454|positive regulation of long-term synaptic depression;GO:1904322|cellular response to forskolin;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005901|caveola;GO:0005905|clathrin-coated pit;GO:0014069|postsynaptic density;GO:0015629|actin cytoskeleton;GO:0016020|membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0030665|clathrin-coated vesicle membrane;GO:0032809|neuronal cell body membrane;GO:0044853|plasma membrane raft;GO:0045121|membrane raft;GO:0048786|presynaptic active zone;GO:0060076|excitatory synapse;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098686|hippocampal mossy fiber to CA3 synapse;GO:0098978|glutamatergic synapse;GO:0099056|integral component of presynaptic membrane;","GO:0003779|actin binding;GO:0004016|adenylate cyclase activity;GO:0005515|protein binding;GO:0005516|calmodulin binding;GO:0005524|ATP binding;GO:0008022|protein C-terminus binding;GO:0008294|calcium- and calmodulin-responsive adenylate cyclase activity;GO:0019902|phosphatase binding;GO:0042803|protein homodimerization activity;GO:0046872|metal ion binding;GO:0046982|protein heterodimerization activity;GO:0046983|protein dimerization activity;GO:0047485|protein N-terminus binding;GO:0051721|protein phosphatase 2A binding;","K08048","ADCY8; adenylate cyclase 8 [EC:4.6.1.1]"]
["ENSRNOG00000005154",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","Alkal2","protein_coding","chr6:47495782-47505234:+","gi|28204858|gb|AAH46522.1|",783,{"v":5e-97,"d":"5.00E-97"},"Acp1 protein, partial [Mus musculus]","gi|187469286|gb|BC167018.1|",1524,0,"Rattus norvegicus hypothetical protein LOC679566, mRNA (cDNA clone MGC:189225 IMAGE:7307720), complete cds","B2RZ42",258,{"v":7e-82,"d":"7.00E-82"},"ALK and LTK ligand 2",".",".",".",".","pfam15129","FAM150","FAM150 family. This family of proteins known as FAM150 is found in eukaryotes. Members of this family are as yet uncharacterized. Proteins in this family are approximately 143 amino acids in length. The function of this family has not, as yet, been determined, however it is predicted to be a secretory protein family.","GO:0010976|positive regulation of neuron projection development;GO:0061098|positive regulation of protein tyrosine kinase activity;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070378|positive regulation of ERK5 cascade;","GO:0005576|extracellular region;","GO:0030298|receptor signaling protein tyrosine kinase activator activity;GO:0030971|receptor tyrosine kinase binding;","K25350","ALKAL; ALK and LTK ligand"]
["ENSRNOG00000007664",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","Tnfrsf13c","protein_coding","chr7:113736055-113738517:-","gi|109481065|ref|XP_576316.2|",652,{"v":2E-78,"d":"2.00E-78"},"PREDICTED: tumor necrosis factor receptor superfamily member 13C [Rattus norvegicus]","gi|672022161|ref|XM_001077542.5|",1725,0,"PREDICTED: Rattus norvegicus tumor necrosis factor receptor superfamily, member 13c (Tnfrsf13c), mRNA","Q9D8D0",219,{"v":3e-66,"d":"3.00E-66"},"Tumor necrosis factor receptor superfamily member 13C",".",".",".",".","pfam09256","BaffR-Tall_bind","BAFF-R, TALL-1 binding. Members of this family, which are predominantly found in the tumor necrosis factor receptor superfamily member 13c, BAFF-R, are required for binding to tumor necrosis factor ligand TALL-1.","GO:0001782|B cell homeostasis;GO:0002636|positive regulation of germinal center formation;GO:0030890|positive regulation of B cell proliferation;GO:0031295|T cell costimulation;GO:0031296|B cell costimulation;GO:0032729|positive regulation of interferon-gamma production;GO:0033209|tumor necrosis factor-mediated signaling pathway;GO:0042102|positive regulation of T cell proliferation;GO:0050776|regulation of immune response;","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0038023|signaling receptor activity;","K05151","TNFRSF13C, BAFFR, CD268; tumor necrosis factor receptor superfamily member 13C"]
["ENSRNOG00000009177",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","Fcer1a","protein_coding","chr13:85686092-85692351:-","gi|6978833|ref|NP_036856.1|",1222,{"v":5E-166,"d":"5.00E-166"},"high affinity immunoglobulin epsilon receptor subunit alpha precursor [Rattus norvegicus]","gi|119709835|ref|NM_012724.4|",1108,0,"Rattus norvegicus Fc fragment of IgE receptor Ia (Fcer1a), mRNA","P12371",475,{"v":2E-167,"d":"2.00E-167"},"High affinity immunoglobulin epsilon receptor subunit alpha",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0001812|positive regulation of type I hypersensitivity;GO:0001820|serotonin secretion;GO:0006955|immune response;GO:0007165|signal transduction;GO:0007166|cell surface receptor signaling pathway;GO:0019370|leukotriene biosynthetic process;GO:0032725|positive regulation of granulocyte macrophage colony-stimulating factor production;GO:0032752|positive regulation of interleukin-3 production;GO:0038095|Fc-epsilon receptor signaling pathway;GO:0043306|positive regulation of mast cell degranulation;GO:0043406|positive regulation of MAP kinase activity;GO:0043507|positive regulation of JUN kinase activity;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050776|regulation of immune response;GO:0050850|positive regulation of calcium-mediated signaling;","GO:0005576|extracellular region;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0004888|transmembrane signaling receptor activity;GO:0019767|IgE receptor activity;GO:0019768|high-affinity IgE receptor activity;GO:0019863|IgE binding;","K08089","FCER1A; high affinity immunoglobulin epsilon receptor subunit alpha"]
["ENSRNOG00000009314",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","Ivl","protein_coding","chr2:178147061-178149100:-","gi|564337550|ref|XP_006232869.1|",1446,0,"PREDICTED: involucrin isoform X1 [Rattus norvegicus]","gi|11559965|ref|NM_022195.1|",1512,0,"Rattus norvegicus involucrin (Ivl), mRNA","P48998",486,{"v":9e-164,"d":"9.00E-164"},"Involucrin",".",".",".",".","pfam06994","Involucrin2","Involucrin. This family represents a conserved region approximately 60 residues long, multiple copies of which are found within eukaryotic involucrin, and which is rich in glutamine and glutamic acid residues. Involucrin forms part of the insoluble cornified cell envelope (a specialized protective barrier) of stratified squamous epithelia. Members of this family seem to be restricted to mammals.","GO:0010224|response to UV-B;GO:0018149|peptide cross-linking;GO:0030216|keratinocyte differentiation;GO:0031424|keratinization;","GO:0001533|cornified envelope;GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0005829|cytosol;GO:0016604|nuclear body;",".",".","."]
["ENSRNOG00000009905",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","Fam166c","protein_coding","chr6:25905294-25923615:-","gi|157817157|ref|NP_001102745.1|",923,{"v":9e-123,"d":"9.00E-123"},"UPF0573 protein C2orf70 homolog [Rattus norvegicus]","gi|157817156|ref|NM_001109275.1|",605,0,"Rattus norvegicus similar to RIKEN cDNA 1700001C02 (RGD1559683), mRNA",".",".",".",".",".",".",".",".","pfam10629","DUF2475","Protein of unknown function (DUF2475). This family of proteins has no known function.",".",".",".",".","."]
["ENSRNOG00000010681",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","Pitx2","protein_coding","chr2:217717693-217737293:+","gi|109948271|ref|NP_001035970.1|",1352,{"v":7e-180,"d":"7.00E-180"},"pituitary homeobox 2 isoform 1 [Rattus norvegicus]","gi|109948270|ref|NM_001042505.1|",2019,0,"Rattus norvegicus paired-like homeodomain 2 (Pitx2), transcript variant 1, mRNA","Q9R0W1",525,0,"Pituitary homeobox 2","YDL106c",52,4e-06,"COG5576","pfam00046","Homeobox","Homeobox domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001569|branching involved in blood vessel morphogenesis;GO:0001570|vasculogenesis;GO:0001701|in utero embryonic development;GO:0001764|neuron migration;GO:0002074|extraocular skeletal muscle development;GO:0003171|atrioventricular valve development;GO:0003253|cardiac neural crest cell migration involved in outflow tract morphogenesis;GO:0003350|pulmonary myocardium development;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007368|determination of left/right symmetry;GO:0007420|brain development;GO:0007507|heart development;GO:0007519|skeletal muscle tissue development;GO:0007520|myoblast fusion;GO:0008584|male gonad development;GO:0008585|female gonad development;GO:0009653|anatomical structure morphogenesis;GO:0009725|response to hormone;GO:0009887|animal organ morphogenesis;GO:0016055|Wnt signaling pathway;GO:0021763|subthalamic nucleus development;GO:0021855|hypothalamus cell migration;GO:0021983|pituitary gland development;GO:0030182|neuron differentiation;GO:0030324|lung development;GO:0030334|regulation of cell migration;GO:0031076|embryonic camera-type eye development;GO:0033189|response to vitamin A;GO:0035116|embryonic hindlimb morphogenesis;GO:0035886|vascular smooth muscle cell differentiation;GO:0035993|deltoid tuberosity development;GO:0042127|regulation of cell proliferation;GO:0042475|odontogenesis of dentin-containing tooth;GO:0042476|odontogenesis;GO:0043010|camera-type eye development;GO:0043388|positive regulation of DNA binding;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048536|spleen development;GO:0048557|embryonic digestive tract morphogenesis;GO:0048738|cardiac muscle tissue development;GO:0055007|cardiac muscle cell differentiation;GO:0055009|atrial cardiac muscle tissue morphogenesis;GO:0055015|ventricular cardiac muscle cell development;GO:0055123|digestive system development;GO:0060412|ventricular septum morphogenesis;GO:0060460|left lung morphogenesis;GO:0060577|pulmonary vein morphogenesis;GO:0060578|superior vena cava morphogenesis;GO:0060971|embryonic heart tube left/right pattern formation;GO:0061031|endodermal digestive tract morphogenesis;GO:0061072|iris morphogenesis;GO:0061325|cell proliferation involved in outflow tract morphogenesis;GO:0070986|left/right axis specification;GO:2000288|positive regulation of myoblast proliferation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005737|cytoplasm;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003700|DNA-binding transcription factor activity;GO:0031490|chromatin DNA binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0043565|sequence-specific DNA binding;GO:0051219|phosphoprotein binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;GO:1990837|sequence-specific double-stranded DNA binding;","K04686","PITX2; paired-like homeodomain transcription factor 2"]
["ENSRNOG00000012119",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","AABR07069282.1","protein_coding","chr8:13946699-13948030:+","gi|392341757|ref|XP_003754418.1|",2242,0,"PREDICTED: serine/threonine-protein kinase Nek2-like [Rattus norvegicus]","gi|672022541|ref|XM_003754370.3|",1332,0,"PREDICTED: Rattus norvegicus NIMA (never in mitosis gene a)-related kinase 2-like 1 (Nek2l1), mRNA","O35942",822,0,"Serine/threonine-protein kinase Nek2",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.",".",".",".",".","."]
["ENSRNOG00000013034",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","Dusp29","protein_coding","chr15:2593578-2633503:+","gi|157821333|ref|NP_001101838.1|",1115,{"v":3e-150,"d":"3.00E-150"},"dual specificity phosphatase DUPD1 [Rattus norvegicus]","gi|157821332|ref|NM_001108368.1|",1106,0,"Rattus norvegicus dual specificity phosphatase and pro isomerase domain containing 1 (Dupd1), mRNA","P0C595",434,{"v":1e-151,"d":"1.00E-151"},"Dual specificity phosphatase DUPD1","SPBC17A3.06",58.9,7e-09,"COG2453","pfam00782","DSPc","Dual specificity phosphatase, catalytic domain. Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a \"recognition\" region.","GO:0006470|protein dephosphorylation;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0042593|glucose homeostasis;GO:0042692|muscle cell differentiation;GO:0043409|negative regulation of MAPK cascade;GO:0070373|negative regulation of ERK1 and ERK2 cascade;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0032991|protein-containing complex;","GO:0004725|protein tyrosine phosphatase activity;GO:0008138|protein tyrosine/serine/threonine phosphatase activity;GO:0033549|MAP kinase phosphatase activity;GO:0042803|protein homodimerization activity;","K14165","K14165; atypical dual specificity phosphatase [EC:3.1.3.16 3.1.3.48]"]
["ENSRNOG00000014070",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","Krt13","protein_coding","chr10:85051889-85056084:-","gi|51591909|ref|NP_001004021.1|",1703,0,"keratin, type I cytoskeletal 13 [Rattus norvegicus]","gi|51591908|ref|NM_001004021.1|",1315,0,"Rattus norvegicus keratin 13, type I (Krt13), mRNA","Q6IFV4",660,0,"Keratin, type I cytoskeletal 13",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0007010|cytoskeleton organization;GO:0009314|response to radiation;GO:0043587|tongue morphogenesis;GO:0071300|cellular response to retinoic acid;","GO:0005575|cellular_component;GO:0045095|keratin filament;GO:0045111|intermediate filament cytoskeleton;GO:0070062|extracellular exosome;","GO:0003674|molecular_function;GO:0005198|structural molecule activity;","K07604","KRT1; type I keratin, acidic"]
["ENSRNOG00000014102",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","Wdr38","protein_coding","chr3:22749396-22753259:+","gi|672016725|ref|XP_003753766.3|",1575,0,"PREDICTED: WD repeat-containing protein 38 isoform X1 [Rattus norvegicus]","gi|564301534|ref|XM_003753718.2|",1185,0,"PREDICTED: Rattus norvegicus WD repeat domain 38 (Wdr38), transcript variant X1, mRNA","Q9D994",551,0,"WD repeat-containing protein 38",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.","GO:0002244|hematopoietic progenitor cell differentiation;",".",".","K24745","WDR38; WD repeat-containing protein 38"]
["ENSRNOG00000015159",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","Slc9a3","protein_coding","chr1:29124674-29167417:-","gi|672034078|ref|XP_008756899.1|",4109,0,"PREDICTED: sodium/hydrogen exchanger 3 isoform X1 [Rattus norvegicus]","gi|6981561|ref|NM_012654.1|",5110,0,"Rattus norvegicus solute carrier family 9 member A3 (Slc9a3), mRNA","P26433",1585,0,"Sodium/hydrogen exchanger 3","SPAC15A10.06",140,{"v":1e-33,"d":"1.00E-33"},"COG0025","pfam00999","Na_H_Exchanger","Sodium/hydrogen exchanger family. Na/H antiporters are key transporters in maintaining the pH of actively metabolizing cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.","GO:0002028|regulation of sodium ion transport;GO:0006814|sodium ion transport;GO:0006885|regulation of pH;GO:0006898|receptor-mediated endocytosis;GO:0007623|circadian rhythm;GO:0051384|response to glucocorticoid;GO:0051453|regulation of intracellular pH;GO:0071805|potassium ion transmembrane transport;GO:0098656|anion transmembrane transport;GO:0098719|sodium ion import across plasma membrane;GO:1902600|proton transmembrane transport;","GO:0005886|plasma membrane;GO:0005903|brush border;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0031526|brush border membrane;GO:0031982|vesicle;GO:0070062|extracellular exosome;","GO:0005515|protein binding;GO:0015385|sodium:proton antiporter activity;GO:0015386|potassium:proton antiporter activity;GO:0030165|PDZ domain binding;","K12040","SLC9A3, NHE3; solute carrier family 9 (sodium/hydrogen exchanger), member 3"]
["ENSRNOG00000015393",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","Slc32a1","protein_coding","chr3:147267373-147271844:+","gi|13929106|ref|NP_113970.1|",2651,0,"vesicular inhibitory amino acid transporter [Rattus norvegicus]","gi|13929105|ref|NM_031782.1|",2371,0,"Rattus norvegicus solute carrier family 32 member 1 (Slc32a1), mRNA","O35458",1025,0,"Vesicular inhibitory amino acid transporter","YIL088c",57.8,7e-08,"COG0814","pfam01490","Aa_trans","Transmembrane amino acid transporter protein. This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.","GO:0006836|neurotransmitter transport;GO:0007568|aging;GO:0015812|gamma-aminobutyric acid transport;GO:0015816|glycine transport;GO:0021766|hippocampus development;GO:0098700|neurotransmitter loading into synaptic vesicle;","GO:0005886|plasma membrane;GO:0008021|synaptic vesicle;GO:0016021|integral component of membrane;GO:0030285|integral component of synaptic vesicle membrane;GO:0030425|dendrite;GO:0043005|neuron projection;GO:0043229|intracellular organelle;GO:0044292|dendrite terminus;GO:0044306|neuron projection terminus;GO:0044316|cone cell pedicle;GO:0045202|synapse;GO:0048786|presynaptic active zone;GO:0051286|cell tip;GO:0060077|inhibitory synapse;GO:0098982|GABA-ergic synapse;","GO:0015187|glycine transmembrane transporter activity;GO:0015495|gamma-aminobutyric acid:proton symporter activity;","K15015","SLC32A, VGAT; solute carrier family 32 (vesicular inhibitory amino acid transporter)"]
["ENSRNOG00000016085",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","Mpzl2","protein_coding","chr8:45348285-45359298:+","gi|157818655|ref|NP_001100288.1|",1034,{"v":3e-129,"d":"3.00E-129"},"myelin protein zero-like protein 2 precursor [Rattus norvegicus]","gi|157818654|ref|NM_001106818.1|",3255,0,"Rattus norvegicus myelin protein zero-like 2 (Mpzl2), mRNA","O70255",355,{"v":1e-112,"d":"1.00E-112"},"Myelin protein zero-like protein 2",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0033077|T cell differentiation in thymus;GO:0098609|cell-cell adhesion;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000016312",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","Catsper4","protein_coding","chr5:146427683-146446942:-","gi|392340819|ref|XP_002726648.2|",2369,0,"PREDICTED: cation channel sperm-associated protein 4 [Rattus norvegicus]","gi|672020007|ref|XM_002726602.4|",1815,0,"PREDICTED: Rattus norvegicus cation channel, sperm associated 4 (Catsper4), mRNA","Q8BVN3",753,0,"Cation channel sperm-associated protein 4","BH1501",95.5,{"v":8e-21,"d":"8.00E-21"},"COG1226","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0006814|sodium ion transport;GO:0030317|flagellated sperm motility;GO:0048240|sperm capacitation;GO:0070588|calcium ion transmembrane transport;","GO:0001669|acrosomal vesicle;GO:0036128|CatSper complex;GO:0097228|sperm principal piece;","GO:0005227|calcium activated cation channel activity;GO:0005245|voltage-gated calcium channel activity;","K16892","CATSPER4; cation channel sperm-associated protein 4"]
["ENSRNOG00000018832",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","RGD1564854","protein_coding","chr3:18154300-18173796:+","gi|564340415|ref|XP_006234053.1|",927,{"v":7e-122,"d":"7.00E-122"},"PREDICTED: uncharacterized protein LOC502617 isoform X1 [Rattus norvegicus]","gi|157819106|ref|NM_001109341.1|",1146,0,"Rattus norvegicus similar to divalent cation tolerant protein CUTA (RGD1564854), mRNA","Q7T3C3",150,{"v":3e-42,"d":"3.00E-42"},"Protein CutA homolog","PAE2325",94.7,{"v":7e-23,"d":"7.00E-23"},"COG1324","pfam03091","CutA1","CutA1 divalent ion tolerance protein. Several gene loci with a possible involvement in cellular tolerance to copper have been identified. One such locus in eubacteria and archaebacteria, cutA, is thought to be involved in cellular tolerance to a wide variety of divalent cations other than copper. The cutA locus consists of two operons, of one and two genes. The CutA1 protein is a cytoplasmic protein, encoded by the single-gene operon and has been linked to divalent cation tolerance. It has no recognized structural motifs. This family also contains putative proteins from eukaryotes (human and Drosophila).","GO:0010038|response to metal ion;","GO:0016021|integral component of membrane;","GO:0005507|copper ion binding;","K03926","cutA; periplasmic divalent cation tolerance protein"]
["ENSRNOG00000019301",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","Lipm","protein_coding","chr1:231618284-231637410:+","gi|109460060|ref|XP_220066.4|",2284,0,"PREDICTED: lipase member M [Rattus norvegicus]","gi|672014792|ref|XM_001079892.4|",1919,0,"PREDICTED: Rattus norvegicus lipase, family member M (Lipm), mRNA","Q8K2A6",861,0,"Lipase member M","SPBC16A3.12c",196,{"v":2e-54,"d":"2.00E-54"},"COG0596","pfam04083","Abhydro_lipase","Partial alpha/beta-hydrolase lipase region. This family corresponds to a N-terminal part of an alpha/beta hydrolase domain.","GO:0016042|lipid catabolic process;",".","GO:0016788|hydrolase activity, acting on ester bonds;","K19406","LIPM; lipase-like abhydrolase domain-containing protein 3 [EC:3.1.1.-]"]
["ENSRNOG00000020080",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","Lrrc18","protein_coding","chr16:8254352-8277437:+","gi|148692902|gb|EDL24849.1|",1342,0,"leucine rich repeat containing 18, partial [Mus musculus]","gi|62078726|ref|NM_001013999.1|",1512,0,"Rattus norvegicus leucine rich repeat containing 18 (Lrrc18), mRNA","Q66HD6",518,0,"Leucine-rich repeat-containing protein 18","alr0124_1",92.4,{"v":3e-19,"d":"3.00E-19"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.",".","GO:0005737|cytoplasm;",".",".","."]
["ENSRNOG00000027733",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","Lair1","protein_coding","chr1:70157681-70185807:+","gi|153945730|ref|NP_001025099.1|",1268,{"v":2e-172,"d":"2.00E-172"},"leukocyte-associated immunoglobulin-like receptor 1 precursor [Rattus norvegicus]","gi|672035182|ref|XM_008758974.1|",1148,0,"PREDICTED: Rattus norvegicus leukocyte-associated immunoglobulin-like receptor 1 (Lair1), transcript variant X1, mRNA","P0C1X9",493,{"v":6e-174,"d":"6.00E-174"},"Leukocyte-associated immunoglobulin-like receptor 1",".",".",".",".","pfam00047","ig","Immunoglobulin domain. Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions. The Pfam alignments do not include the first and last strand of the immunoglobulin-like domain.",".","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;",".","K06725","LAIR, CD305_6; leukocyte-associated Ig-like receptor"]
["ENSRNOG00000027843",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","Kir3dl1","protein_coding","chr1:69715535-69754050:-","gi|31324550|ref|NP_852144.1|",2059,0,"killer cell immunoglobulin-like receptor 3DL1 precursor [Rattus norvegicus]","gi|31340701|ref|NM_181479.2|",1287,0,"Rattus norvegicus killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 (Kir3dl1), mRNA","P83556",797,0,"Killer cell immunoglobulin-like receptor 3DL1",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0042267|natural killer cell mediated cytotoxicity;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;",".","K07980","KIR3DL, CD158; killer cell immunoglobulin-like receptor 3DL"]
["ENSRNOG00000028089",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","Apobec4","protein_coding","chr13:64887012-64895053:+","gi|71681387|gb|AAI00466.1|",1452,0,"Apobec4 protein, partial [Mus musculus]","gi|672074507|ref|XM_008769666.1|",1845,0,"PREDICTED: Rattus norvegicus apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) (Apobec4), transcript variant X1, mRNA","Q6AXX9",814,0,"Putative C->U-editing enzyme APOBEC-4",".",".",".",".","pfam08210","APOBEC_N","APOBEC-like N-terminal domain. A mechanism of generating protein diversity is mRNA editing. Members of this family are C-to-U editing enzymes. The N-terminal domain of APOBEC-1 like proteins is the catalytic domain, while the C-terminal domain is a pseudocatalyitc domain. More specifically, the catalytic domain is a zinc dependent deaminases domain and is essential for cytidine deamination.APOBEC-3 like members contain two copies of this domain. RNA editing by APOBEC-1 requires homodimerization and this complex interacts with RNA binding proteins to from the editosome (and references therein). This family also includes the functionally homologous activation induced deaminase (AID), which is essential for the development of antibody diversity in B lymphocytes, and the sea lamprey PmCDA1 and PmCDA2, which are predicted to play an AID-like role in the adaptive immune response of jawless vertebrates. Divergent members of this family are present in various eukaryotes such as Nematostella, C. elegans, Micromonas and Emiliania, and prokaryotes such as Wolbachia and Pseudomonas brassicacearum.","GO:0006397|mRNA processing;",".","GO:0016787|hydrolase activity;GO:0046872|metal ion binding;","K18773","APOBEC4; C->U-editing enzyme APOBEC4 [EC:3.5.4.-]"]
["ENSRNOG00000029508",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","Slpil2","protein_coding","chr3:153019109-153021360:-","gi|57114320|ref|NP_001008872.1|",649,{"v":2e-83,"d":"2.00E-83"},"antileukoproteinase-like 2 precursor [Rattus norvegicus]","gi|672048203|ref|XM_008762532.1|",412,0,"PREDICTED: Rattus norvegicus antileukoproteinase-like 2 (Slpil2), transcript variant X1, mRNA","P97430",171,{"v":2E-52,"d":"2.00E-52"},"Antileukoproteinase",".",".",".",".","pfam00095","WAP","WAP-type (Whey Acidic Protein) 'four-disulfide core'.","GO:0010951|negative regulation of endopeptidase activity;GO:0019731|antibacterial humoral response;GO:0045087|innate immune response;","GO:0005615|extracellular space;","GO:0004867|serine-type endopeptidase inhibitor activity;",".","."]
["ENSRNOG00000029881",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","Clec4m","protein_coding","chr12:1915919-1924539:-","gi|60688435|gb|AAH91252.1|",1500,0,"Cd209b protein, partial [Rattus norvegicus]","gi|281371433|ref|NM_001170397.1|",1129,0,"Rattus norvegicus CD209b antigen (Cd209b), mRNA","Q8CJ91",493,{"v":3e-172,"d":"3.00E-172"},"CD209 antigen-like protein B",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0001879|detection of yeast;GO:0006897|endocytosis;GO:0006910|phagocytosis, recognition;GO:0016045|detection of bacterium;GO:0032760|positive regulation of tumor necrosis factor production;GO:0046718|viral entry into host cell;GO:0050766|positive regulation of phagocytosis;","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0001618|virus receptor activity;GO:0001872|(1->3)-beta-D-glucan binding;GO:0005537|mannose binding;GO:0030247|polysaccharide binding;GO:0048306|calcium-dependent protein binding;","K06563","CLEC4M, DC-SIGN2, CD209, CD299; C-type lectin domain family 4 member M"]
["ENSRNOG00000035562",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","Mir30c2","miRNA","chr9:25757342-25757425:+",".",".",".",".","gi|297139689|ref|NR_031844.1|",84,{"v":3e-35,"d":"3.00E-35"},"Rattus norvegicus microRNA 30c-2 (Mir30c2), microRNA",".",".",".",".",".",".",".",".","pfam06627","DUF1153","Protein of unknown function (DUF1153). This family consists of several short, hypothetical bacterial proteins of unknown function.","GO:0009617|response to bacterium;GO:0010629|negative regulation of gene expression;GO:0045668|negative regulation of osteoblast differentiation;GO:0060291|long-term synaptic potentiation;GO:0071222|cellular response to lipopolysaccharide;GO:0071241|cellular response to inorganic substance;GO:1904322|cellular response to forskolin;","GO:0016442|RISC complex;",".","K17040","MIR30C; microRNA 30c"]
["ENSRNOG00000038291",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","Lrrc63","protein_coding","chr15:50400200-50437321:-","gi|67078412|ref|NP_001019974.1|",2970,0,"leucine-rich repeat-containing protein 63 [Rattus norvegicus]","gi|67078411|ref|NM_001024803.1|",2467,0,"Rattus norvegicus leucine rich repeat containing 63 (Lrrc63), mRNA","Q4V8G0",1149,0,"Leucine-rich repeat-containing protein 63","ECU09g0190",95.9,{"v":3e-20,"d":"3.00E-20"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.",".",".",".",".","."]
["ENSRNOG00000040121",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","RGD1565158","protein_coding","chr10:2240584-2381458:+","gi|672024461|ref|XP_008772239.1|",1385,{"v":1E-179,"d":"1.00E-179"},"PREDICTED: ankyrin repeat domain-containing protein 7-like isoform X1 [Rattus norvegicus]","gi|672024466|ref|XM_008774043.1|",1026,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103693260 (LOC103693260), mRNA","Q811D2",176,{"v":4e-43,"d":"4.00E-43"},"Ankyrin repeat domain-containing protein 26","FN0178",87.8,{"v":1e-17,"d":"1.00E-17"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).",".",".",".",".","."]
["ENSRNOG00000042497",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","Mymx","protein_coding","chr9:15397144-15398263:+","gi|294489328|ref|NP_001170939.1|",207,{"v":8e-18,"d":"8.00E-18"},"embryonic stem cell- and germ cell-specific protein isoform 1 [Mus musculus]","gi|755558817|ref|XM_006524789.2|",464,0,"PREDICTED: Mus musculus predicted gene 7325 (Gm7325), transcript variant X1, mRNA","Q2Q5T5",84.3,{"v":3e-19,"d":"3.00E-19"},"Protein myomixer",".",".",".",".","pfam13920","zf-C3HC4_3","Zinc finger, C3HC4 type (RING finger).","GO:0007520|myoblast fusion;GO:0014905|myoblast fusion involved in skeletal muscle regeneration;GO:0043403|skeletal muscle tissue regeneration;GO:0045026|plasma membrane fusion;GO:0060538|skeletal muscle organ development;","GO:0000139|Golgi membrane;GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;",".","K24578","MYMX; protein myomixer"]
["ENSRNOG00000043331",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","Ankrd65","protein_coding","chr5:166397748-166400953:+","gi|157821725|ref|NP_001102897.1|",1565,0,"ankyrin repeat domain-containing protein 65 [Rattus norvegicus]","gi|157821724|ref|NM_001109427.1|",1269,0,"Rattus norvegicus ankyrin repeat domain 65 (Ankrd65), mRNA",".",".",".",".","all2748",85.5,{"v":5e-17,"d":"5.00E-17"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).",".",".",".",".","."]
["ENSRNOG00000046057",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","Pnmt","protein_coding","chr10:83384923-83386556:+","gi|149054109|gb|EDM05926.1|",1442,0,"rCG32571 [Rattus norvegicus]","gi|158081716|ref|NM_031526.1|",933,0,"Rattus norvegicus phenylethanolamine-N-methyltransferase (Pnmt), mRNA","P10937",556,0,"Phenylethanolamine N-methyltransferase",".",".",".",".","pfam01234","NNMT_PNMT_TEMT","NNMT/PNMT/TEMT family.","GO:0001666|response to hypoxia;GO:0009409|response to cold;GO:0009414|response to water deprivation;GO:0014823|response to activity;GO:0030325|adrenal gland development;GO:0031960|response to corticosteroid;GO:0032259|methylation;GO:0032868|response to insulin;GO:0035176|social behavior;GO:0035900|response to isolation stress;GO:0035902|response to immobilization stress;GO:0042415|norepinephrine metabolic process;GO:0042418|epinephrine biosynthetic process;GO:0043434|response to peptide hormone;GO:0045471|response to ethanol;GO:0045472|response to ether;GO:0046498|S-adenosylhomocysteine metabolic process;GO:0046500|S-adenosylmethionine metabolic process;GO:0050909|sensory perception of taste;GO:0071363|cellular response to growth factor stimulus;GO:0071375|cellular response to peptide hormone stimulus;GO:0071549|cellular response to dexamethasone stimulus;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0030424|axon;GO:0030425|dendrite;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0043196|varicosity;GO:0043204|perikaryon;","GO:0004603|phenylethanolamine N-methyltransferase activity;GO:0008168|methyltransferase activity;GO:0008170|N-methyltransferase activity;GO:0008757|S-adenosylmethionine-dependent methyltransferase activity;GO:0016740|transferase activity;","K00553","PNMT; phenylethanolamine N-methyltransferase [EC:2.1.1.28]"]
["ENSRNOG00000047006",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","Mir2985","miRNA","chr2:165956389-165956498:-",".",".",".",".","gi|312147369|ref|NR_037389.1|",110,{"v":2e-49,"d":"2.00E-49"},"Rattus norvegicus microRNA 2985 (Mir2985), microRNA",".",".",".",".",".",".",".",".","pfam06380","DUF1072","Protein of unknown function (DUF1072). This family consists of several Barley yellow dwarf virus proteins of unknown function.",".",".",".",".","."]
["ENSRNOG00000048802",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","ENSRNOG00000048802","protein_coding","chr8:99791981-99810228:-","gi|564310520|ref|XP_006226600.1|",941,{"v":3E-124,"d":"3.00E-124"},"PREDICTED: fas apoptotic inhibitory molecule 1 [Rattus norvegicus]","gi|672023237|ref|XM_008757849.1|",822,0,"PREDICTED: Rattus norvegicus similar to Fas apoptotic inhibitory molecule 1 (rFAIM) (LOC684466), transcript variant X6, mRNA","Q8R5H8",317,{"v":8e-106,"d":"8.00E-106"},"Fas apoptotic inhibitory molecule 1",".",".",".",".","pfam06905","FAIM1","Fas apoptotic inhibitory molecule (FAIM1). This family consists of several fas apoptotic inhibitory molecule (FAIM1) proteins. FAIM expression is upregulated in B cells by anti-Ig treatment that induces Fas-resistance, and overexpression of FAIM diminishes sensitivity to Fas-mediated apoptosis of B and non-B cell lines. FAIM1 is highly evolutionarily conserved and is widely expressed in murine tissues, suggesting that FAIM plays an important role in cellular physiology.",".",".",".",".","."]
["ENSRNOG00000052519",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","Ttc30a1","protein_coding","chr3:60899196-60901634:-","gi|71361631|ref|NP_001025089.1|",3482,0,"tetratricopeptide repeat protein 30A2 [Rattus norvegicus]","gi|71361630|ref|NM_001029918.1|",2439,0,"Rattus norvegicus tetratricopeptide repeat domain 30A1 (Ttc30a1), mRNA","Q4QQS2",1345,0,"Tetratricopeptide repeat protein 30A2",".",".",".",".","pfam14559","TPR_19","Tetratricopeptide repeat.","GO:0042073|intraciliary transport;","GO:0005813|centrosome;GO:0005879|axonemal microtubule;GO:0005929|cilium;GO:0030992|intraciliary transport particle B;GO:0036064|ciliary basal body;","GO:0120170|intraciliary transport particle B binding;","K19683","TTC30, DYF1; tetratricopeptide repeat protein 30"]
["ENSRNOG00000052644",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","AABR07001060.1","snoRNA","chr1:33716713-33716842:-","gi|149025889|gb|EDL82132.1|",185,{"v":2e-17,"d":"2.00E-17"},"rCG28667, isoform CRA_b [Rattus norvegicus]","gi|908662900|tpe|LN872364.1|",117,{"v":3e-53,"d":"3.00E-53"},"TPA: Mus musculus SNORA24 (ACA24) gene for small nucleolar RNA SNORA24 (ACA24)",".",".",".",".",".",".",".",".","pfam14724","mit_SMPDase","Mitochondrial-associated sphingomyelin phosphodiesterase. The GO annotation for this family indicates that it is a single-pass membrane protein, and it appears to be found in mitochondrial membranes. Sphingolipids play important roles in regulating cellular responses, and although mitochondria contain sphingolipids, direct regulation of their levels in mitochondria or mitochondria-associated membranes is mostly unclear. Sphingomyelin phosphodiesterases catalyse the hydrolysis of sphingomyelin to ceramide and phosphocholine, and these metabolites are involved in signalling pathways.",".",".",".",".","."]
["ENSRNOG00000054013",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","Clec4g","protein_coding","chr12:1780371-1784985:-","gi|672072155|ref|XP_008767238.1|",1319,{"v":2E-179,"d":"2.00E-179"},"PREDICTED: LOW QUALITY PROTEIN: C-type lectin domain family 4 member G isoform X2 [Rattus norvegicus]","gi|672072154|ref|XM_008769016.1|",1134,0,"PREDICTED: Rattus norvegicus C-type lectin domain family 4, member G (Clec4g), transcript variant X2, mRNA","Q8BNX1",483,{"v":2E-169,"d":"2.00E-169"},"C-type lectin domain family 4 member G",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0002710|negative regulation of T cell mediated immunity;GO:0042130|negative regulation of T cell proliferation;GO:0046718|viral entry into host cell;GO:1903902|positive regulation of viral life cycle;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;","GO:0001618|virus receptor activity;GO:0005537|mannose binding;GO:0030247|polysaccharide binding;GO:0070061|fructose binding;GO:0097367|carbohydrate derivative binding;","K10061","CLEC4G; C-type lectin superfamily 4 member G"]
["ENSRNOG00000056335",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","AC113635.2","protein_coding","chr2:194700575-194700928:+","gi|149025616|gb|EDL81859.1|",505,{"v":2e-63,"d":"2.00E-63"},"rCG28946 [Rattus norvegicus]","gi|26353915|dbj|AK088812.1|",190,{"v":2e-93,"d":"2.00E-93"},"Mus musculus 2 days neonate thymus thymic cells cDNA, RIKEN full-length enriched library, clone:E430026I03 product:hypothetical protein, full insert sequence",".",".",".",".",".",".",".",".","pfam00519","PPV_E1_C","Papillomavirus helicase. This protein is a DNA helicase that is required for initiation of viral DNA replication. This protein forms a complex with the E2 protein pfam00508.",".",".",".",".","."]
["ENSRNOG00000057697",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","U6","snRNA","chr1:196288031-196288126:-",".",".",".",".","gi|34368595|gb|AC118351.14|",96,{"v":8e-42,"d":"8.00E-42"},"Rattus norvegicus 1 BAC CH230-362O18 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam08454","RIH_assoc","RyR and IP3R Homology associated. This eukaryotic domain is found in ryanodine receptors (RyR) and inositol 1,4,5-trisphosphate receptors (IP3R) which together form a superfamily of homotetrameric ligand-gated intracellular Ca2+ channels. There seems to be no known function for this domain. Also see the IP3-binding domain pfam01365 and pfam02815.",".",".",".",".","."]
["ENSRNOG00000059842",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","AABR07012588.1","protein_coding","chr2:184019212-184019587:+","gi|74203709|dbj|BAE23096.1|",215,{"v":8e-21,"d":"8.00E-21"},"unnamed protein product [Mus musculus]","gi|755505303|ref|XR_867480.1|",101,{"v":4e-44,"d":"4.00E-44"},"PREDICTED: Mus musculus uncharacterized LOC102632901 (LOC102632901), transcript variant X8, misc_RNA",".",".",".",".",".",".",".",".","pfam09815","XK-related","XK-related protein. Members of this family comprise various XK-related proteins, that are involved in sodium-dependent transport of neutral amino acids or oligopeptides. These proteins are responsible for the Kx blood group system - defects results in McLeod syndrome, an X-linked multi-system disorder characterized by late onset abnormalities in the neuromuscular and hematopoietic systems.",".",".",".",".","."]
["ENSRNOG00000062351",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","ENSRNOG00000062351","protein_coding","chr18:11639566-11640877:+","gi|351710366|gb|EHB13285.1|",276,{"v":2e-28,"d":"2.00E-28"},"Apoptosis inhibitor 5 [Heterocephalus glaber]","gi|940748482|ref|XR_001349485.1|",112,{"v":5e-50,"d":"5.00E-50"},"PREDICTED: Myotis lucifugus apoptosis inhibitor 5 pseudogene (LOC102428191), misc_RNA","Q5R644",109,{"v":2e-27,"d":"2.00E-27"},"Apoptosis inhibitor 5",".",".",".",".","pfam05918","API5","Apoptosis inhibitory protein 5 (API5). This family consists of apoptosis inhibitory protein 5 (API5) sequences from several organisms. Apoptosis or programmed cell death is a physiological form of cell death that occurs in embryonic development and organ formation. It is characterized by biochemical and morphological changes such as DNA fragmentation and cell volume shrinkage. API5 is an anti apoptosis gene located in human chromosome 11, whose expression prevents the programmed cell death that occurs upon the deprivation of growth factors.",".",".",".",".","."]
["ENSRNOG00000062520",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","ENSRNOG00000062520","snoRNA","chr6:132368903-132369027:-",".",".",".",".","gi|820703338|tpe|LN847631.1|",37,7e-09,"TPA: Homo sapiens SNORA40L2 gene for small nucleolar RNA SNORA40L2",".",".",".",".",".",".",".",".","pfam10433","MMS1_N","Mono-functional DNA-alkylating methyl methanesulfonate N-term. MMS1 is a protein that protects against replication-dependent DNA damage in Saccharomyces cerevisiae. MMS1 belongs to the DDB1 family of cullin 4 adaptors and the two proteins are homologous. MMS1 bridges the interaction of MMS22 and Crt10 with Cul8/Rtt101. Cul8/Rtt101 is a cullin protein involved in the regulation of DNA replication subsequent to DNA damage. The N-terminal region of MMS1 and the C-terminal of MMS22 are required for the the MMS1-MMS22 interaction. The human HIV-1 virion-associated protein Vpr assembles with DDB1 through interaction with DCAF1 (chromatin assembly factor) to form an E3 ubiquitin ligase that targets cellular substrates for proteasome-mediated degradation and subsequent G2 arrest.",".",".",".",".","."]
["ENSRNOG00000062536",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","ENSRNOG00000062536","lncRNA","chr5:144238211-144239578:+",".",".",".",".","gi|22531402|emb|AL669981.11|",634,0,"Mouse DNA sequence from clone RP23-335B9 on chromosome 4, complete sequence",".",".",".",".",".",".",".",".","pfam03925","SeqA","SeqA protein. The binding of SeqA protein to hemimethylated GATC sequences is important in the negative modulation of chromosomal initiation at oriC, and in the formation of SeqA foci necessary for Escherichia coli chromosome segregation. SeqA tetramers are able to aggregate or multimerize in a reversible, concentration-dependent manner. Apart from its function in the control of DNA replication, SeqA may also be a specific transcription factor.",".",".",".",".","."]
["ENSRNOG00000062742",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","ENSRNOG00000062742","lncRNA","chr12:15884585-15894265:+",".",".",".",".","gi|755514887|ref|XM_006504775.2|",483,0,"PREDICTED: Mus musculus family with sequence similarity 20, member C (Fam20c), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam15373","DUF4601","Domain of unknown function (DUF4601). This protein family is a domain of unknown function, which is found in eukaryotes. In humans, the gene encoding this protein is found in the position, chromosome 19 open reading frame 45.",".",".",".",".","."]
["ENSRNOG00000062790",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","ENSRNOG00000062790","protein_coding","chr4:102446979-102447651:-","gi|149037292|gb|EDL91767.1|",548,{"v":7e-69,"d":"7.00E-69"},"rCG64257, partial [Rattus norvegicus]","gi|298897982|emb|FQ231172.1|",234,{"v":1E-117,"d":"1.00E-117"},"Rattus norvegicus TL0AEA7YB01 mRNA sequence","P01633",184,{"v":6e-58,"d":"6.00E-58"},"Ig kappa chain V19-17",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000062957",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","ENSRNOG00000062957","processed_pseudogene","chr2:78910645-78911163:+","gi|672015539|ref|XP_008773316.1|",906,{"v":7e-119,"d":"7.00E-119"},"PREDICTED: LOW QUALITY PROTEIN: keratin, type I cytoskeletal 18-like isoform X1 [Rattus norvegicus]","gi|672041762|ref|XM_008760823.1|",519,0,"PREDICTED: Rattus norvegicus similar to keratin complex 1, acidic, gene 18 (LOC683212), transcript variant X2, mRNA","Q5BJY9",339,{"v":1e-114,"d":"1.00E-114"},"Keratin, type I cytoskeletal 18",".",".",".",".","pfam00038","Filament","Intermediate filament protein.",".",".",".",".","."]
["ENSRNOG00000063796",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","Foxf2","protein_coding","chr17:32836777-32842176:-","gi|242397402|ref|NP_034355.2|",1347,{"v":8e-177,"d":"8.00E-177"},"forkhead box protein F2 [Mus musculus]","gi|672081638|ref|XM_008771604.1|",1956,0,"PREDICTED: Rattus norvegicus forkhead box F2 (Foxf2), transcript variant X2, mRNA","O54743",523,{"v":3e-178,"d":"3.00E-178"},"Forkhead box protein F2","SPBC4C3.05",86.7,{"v":9e-17,"d":"9.00E-17"},"COG5025","pfam00250","Fork_head","Fork head domain.",".",".",".",".","."]
["ENSRNOG00000064003",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","ENSRNOG00000064003","protein_coding","chr4:100511833-100512330:-","gi|149037306|gb|EDL91781.1|",496,{"v":6e-62,"d":"6.00E-62"},"rCG53372, partial [Rattus norvegicus]","gi|56789709|gb|BC088255.1|",355,0,"Rattus norvegicus similar to IG KAPPA CHAIN V-V REGION K2 PRECURSOR, mRNA (cDNA clone IMAGE:7375130)","P01599",151,{"v":4e-46,"d":"4.00E-46"},"Immunoglobulin kappa variable 1-17",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000064199",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","Stfa2","protein_coding","chr11:64544466-64549448:+","gi|564314489|ref|XP_006221215.1|",545,{"v":2e-69,"d":"2.00E-69"},"PREDICTED: stefin-2-like isoform X1 [Rattus norvegicus]","gi|672026107|ref|XM_006221153.2|",403,0,"PREDICTED: Rattus norvegicus stefin A2 (Stfa2), transcript variant X1, mRNA","P35174",166,{"v":6E-52,"d":"6.00E-52"},"Stefin-2",".",".",".",".","pfam00031","Cystatin","Cystatin domain. Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 are related to this family but have not been included.",".",".",".",".","."]
["ENSRNOG00000064463",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","U6","snRNA","chr1:181409122-181409228:+","gi|537152882|gb|ERE72362.1|",186,{"v":4e-16,"d":"4.00E-16"},"membralin-like protein [Cricetulus griseus]","gi|951234517|ref|NG_045051.1|",104,{"v":3e-46,"d":"3.00E-46"},"Homo sapiens RNA, U6 small nuclear 5, pseudogene (RNU6-5P) on chromosome 2",".",".",".",".",".",".",".",".","pfam08538","DUF1749","Protein of unknown function (DUF1749). This is a plant and fungal family of unknown function. This family contains many hypothetical proteins.",".",".",".",".","."]
["ENSRNOG00000064789",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","ENSRNOG00000064789","protein_coding","chr4:100855156-100855756:-","gi|5327163|emb|CAB46328.1|",491,{"v":4e-61,"d":"4.00E-61"},"immunoglobulin light chain variable region [Mus musculus]","gi|197033|gb|M19913.1|MUSIGKCNJ",220,{"v":5E-110,"d":"5.00E-110"},"Mouse Ig rearranged kappa-chain mRNA, clone AN11K","P01642",177,{"v":3e-56,"d":"3.00E-56"},"Ig kappa chain V-V region L7 (Fragment)",".",".",".",".","pfam00047","ig","Immunoglobulin domain. Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions. The Pfam alignments do not include the first and last strand of the immunoglobulin-like domain.",".",".",".",".","."]
["ENSRNOG00000064940",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","ENSRNOG00000064940","pseudogene","chr4:101065787-101066143:-","gi|68534280|gb|AAH98746.1|",500,{"v":3e-61,"d":"3.00E-61"},"LOC500183 protein [Rattus norvegicus]","gi|298895092|emb|FQ234636.1|",284,{"v":1e-145,"d":"1.00E-145"},"Rattus norvegicus TL0AEA58YD13 mRNA sequence","P01635",143,{"v":2e-43,"d":"2.00E-43"},"Ig kappa chain V-V region K2 (Fragment)",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000064951",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","Acsm2","protein_coding","chr1:173916368-173955116:+","gi|672037677|ref|XP_008757899.1|",3076,0,"PREDICTED: acyl-coenzyme A synthetase ACSM2, mitochondrial isoform X1 [Rattus norvegicus]","gi|21426768|ref|NM_144748.1|",2417,0,"Rattus norvegicus acyl-CoA synthetase medium-chain family member 2A (Acsm2a), mRNA","O70490",1186,0,"Acyl-coenzyme A synthetase ACSM2, mitochondrial","MA2912",356,{"v":2e-111,"d":"2.00E-111"},"COG0365","pfam00501","AMP-binding","AMP-binding enzyme.",".",".",".",".","."]
["ENSRNOG00000065181",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","ENSRNOG00000065181","protein_coding","chr6:133277540-133278078:-","gi|149034273|gb|EDL89023.1|",635,{"v":1e-82,"d":"1.00E-82"},"rCG21070, partial [Rattus norvegicus]","gi|9887321|gb|AF286343.1|AF286343",400,0,"Rattus norvegicus immunoglobulin 4G6 heavy chain variable region mRNA, partial cds","P0DP02",196,{"v":1e-63,"d":"1.00E-63"},"Immunoglobulin heavy variable 3-30-3",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000065292",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","ENSRNOG00000065292","lncRNA","chr1:95587760-95603022:-",".",".",".",".","gi|568892662|ref|XR_403087.1|",48,{"v":7e-14,"d":"7.00E-14"},"PREDICTED: Mus musculus predicted gene, 36186 (Gm36186), ncRNA",".",".",".",".",".",".",".",".","pfam07970","COPIIcoated_ERV","Endoplasmic reticulum vesicle transporter. This family is conserved from plants and fungi to humans. Erv46 works in close conjunction with Erv41 and together they form a complex which cycles between the endoplasmic reticulum and Golgi complex. Erv46-41 interacts strongly with the endoplasmic reticulum glucosidase II. Mammalian glucosidase II comprises a catalytic alpha-subunit and a 58 kDa beta subunit, which is required for ER localisation. All proteins identified biochemically as Erv41p-Erv46p interactors are localized to the early secretory pathway and are involved in protein maturation and processing in the ER and/or sorting into COPII vesicles for transport to the Golgi.",".",".",".",".","."]
["ENSRNOG00000065439",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","ENSRNOG00000065439","lncRNA","chr20:46043679-46046546:+",".",".",".",".","gi|50080371|gb|AC121152.15|",326,{"v":2e-168,"d":"2.00E-168"},"Mus musculus chromosome 10, clone RP24-344A4, complete sequence",".",".",".",".",".",".",".",".","pfam05088","Bac_GDH","Bacterial NAD-glutamate dehydrogenase. This family consists of several bacterial proteins which are closely related to NAD-glutamate dehydrogenase found in Streptomyces clavuligerus. Glutamate dehydrogenases (GDHs) are a broadly distributed group of enzymes that catalyse the reversible oxidative deamination of glutamate to ketoglutarate and ammonia.",".",".",".",".","."]
["ENSRNOG00000065788",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","Zfp683","protein_coding","chr5:146278978-146285000:+","gi|672020004|ref|XP_002726647.2|",2352,0,"PREDICTED: zinc finger protein 683 [Rattus norvegicus]","gi|672020003|ref|XM_002726601.3|",1434,0,"PREDICTED: Rattus norvegicus zinc finger protein 683 (Zfp683), mRNA","I7HJS4",720,0,"Tissue-resident T-cell transcription regulator protein ZNF683",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.",".",".",".",".","."]
["ENSRNOG00000065855",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","ENSRNOG00000065855","protein_coding","chr4:98386485-98387112:+","gi|672033183|ref|XP_008756365.1|",817,{"v":9e-108,"d":"9.00E-108"},"PREDICTED: immunoglobulin superfamily member 3-like isoform X1 [Rattus norvegicus]","gi|672033182|ref|XM_008758143.1|",475,0,"PREDICTED: Rattus norvegicus Ig kappa chain V-V region HP 123E6-like (LOC684133), transcript variant X1, mRNA","P01681",175,{"v":1E-54,"d":"1.00E-54"},"Ig kappa chain V region S211",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000066082",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","ENSRNOG00000066082","IG_V_gene","chr4:99389747-99390073:-","gi|118764033|gb|AAI28282.1|",456,{"v":3e-56,"d":"3.00E-56"},"Igk protein [Mus musculus]","gi|298902451|emb|FQ231704.1|",299,{"v":5e-154,"d":"5.00E-154"},"Rattus norvegicus TL0AEA68YI02 mRNA sequence","P01644",159,{"v":2e-49,"d":"2.00E-49"},"Ig kappa chain V-V region HP R16.7",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000066926",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","ENSRNOG00000066926","protein_coding","chr6:136231312-136231847:-","gi|148686352|gb|EDL18299.1|",443,{"v":6e-54,"d":"6.00E-54"},"mCG50839 [Mus musculus]","gi|1911159|emb|Z93368.1|",247,{"v":5e-125,"d":"5.00E-125"},"R.norvegicus mRNA for immunoglobulin variable region (clone ERF2.67)","P01814",143,{"v":7e-43,"d":"7.00E-43"},"Immunoglobulin heavy variable 2-70",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000067342",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","ENSRNOG00000067342","lncRNA","chr4:167667845-167673152:-","gi|148701441|gb|EDL33388.1|",161,{"v":9e-11,"d":"9.00E-11"},"mCG1045525, partial [Mus musculus]","gi|38259261|gb|AC142227.3|",149,{"v":2e-69,"d":"2.00E-69"},"Mus musculus BAC clone RP24-115G21 from chromosome 12, complete sequence",".",".",".",".",".",".",".",".","pfam13295","DUF4077","Domain of unknown function (DUF4077). This is the N-terminal region of methyl-accepting chemotaxis proteins from Bacillus spp. The function is not known.",".",".",".",".","."]
["ENSRNOG00000067850",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","ENSRNOG00000067850","protein_coding","chr2:120910598-120912239:-","gi|354486538|ref|XP_003505437.1|",1458,0,"PREDICTED: D-3-phosphoglycerate dehydrogenase [Cricetulus griseus]","gi|564338012|ref|XM_006233010.1|",482,0,"PREDICTED: Rattus norvegicus phosphoglycerate dehydrogenase (Phgdh), transcript variant X1, mRNA","Q61753",562,0,"D-3-phosphoglycerate dehydrogenase","MJ1018",271,{"v":1E-83,"d":"1.00E-83"},"COG0111","pfam00389","2-Hacid_dh","D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. This family represents the largest portion of the catalytic domain of 2-hydroxyacid dehydrogenases as the NAD binding domain is inserted within the structural domain.",".",".",".",".","."]
["ENSRNOG00000068268",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","ENSRNOG00000068268","protein_coding","chr4:100928809-100929165:-","gi|149037305|gb|EDL91780.1|",447,{"v":1E-54,"d":"1.00E-54"},"rCG53375, partial [Rattus norvegicus]","gi|298894562|emb|FQ227555.1|",228,{"v":2e-114,"d":"2.00E-114"},"Rattus norvegicus TL0AEA12YO17 mRNA sequence","P01635",145,{"v":1e-43,"d":"1.00E-43"},"Ig kappa chain V-V region K2 (Fragment)",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000068892",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","U6","snRNA","chr4:102735624-102735728:+",".",".",".",".","gi|50872596|gb|AC123597.9|",79,{"v":3E-32,"d":"3.00E-32"},"Mus musculus chromosome 8, clone RP23-134A7, complete sequence",".",".",".",".",".",".",".",".","pfam11925","DUF3443","Protein of unknown function (DUF3443). This family of proteins are functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 400 to 434 amino acids in length. This protein has two conserved sequence motifs: NPV and DNNG.",".",".",".",".","."]
["ENSRNOG00000069444",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","ENSRNOG00000069444","protein_coding","chr6:134596525-134597057:-","gi|344257616|gb|EGW13720.1|",413,{"v":5e-49,"d":"5.00E-49"},"Ig heavy chain V region M315 [Cricetulus griseus]","gi|62201946|gb|BC092582.1|",173,{"v":7e-84,"d":"7.00E-84"},"Rattus norvegicus similar to single chain Fv antibody fragment scFv 7-10A, mRNA (cDNA clone IMAGE:7373926)","P18531",145,{"v":1e-43,"d":"1.00E-43"},"Ig heavy chain V region 3-6",".",".",".",".","pfam04299","FMN_bind_2","Putative FMN-binding domain. In Bacillus subtilis, family member PAI 2/ORF-2 was found to be essential for growth. The SUPERFAMILY database finds that this domain is related to FMN-binding domains, suggesting this protein is also FMN-binding.",".",".",".",".","."]
["ENSRNOG00000069468",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","ENSRNOG00000069468","protein_coding","chr10:64877631-64879869:-","gi|68534953|ref|NP_446428.1|",1535,0,"keratin, type I cytoskeletal 18 [Rattus norvegicus]","gi|68534952|ref|NM_053976.1|",830,0,"Rattus norvegicus keratin 18, type I (Krt18), mRNA","Q5BJY9",595,0,"Keratin, type I cytoskeletal 18",".",".",".",".","pfam00038","Filament","Intermediate filament protein.",".",".",".",".","."]
["ENSRNOG00000069531",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","ENSRNOG00000069531","lncRNA","chr12:440804-443091:+","gi|149022070|gb|EDL78964.1|",150,2E-8,"rCG27106 [Rattus norvegicus]","gi|111038160|gb|AC114360.5|",195,{"v":2E-95,"d":"2.00E-95"},"Rattus norvegicus BAC CH230-76E6 () complete sequence",".",".",".",".",".",".",".",".","pfam10486","PI3K_1B_p101","Phosphoinositide 3-kinase gamma adapter protein p101 subunit. Class I PI3Ks are dual-specific lipid and protein kinases involved in numerous intracellular signaling pathways. Class IB PI3K, p110gamma, is mainly activated by seven-transmembrane G-protein-coupled receptors (GPCRs), through its regulatory subunit p101 and G-protein beta-gamma subunits.",".",".",".",".","."]
["ENSRNOG00000069803",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","ENSRNOG00000069803","lncRNA","chr1:150562353-150729493:+","gi|26327259|dbj|BAC27373.1|",207,{"v":4e-17,"d":"4.00E-17"},"unnamed protein product [Mus musculus]","gi|74013485|gb|AC158136.11|",555,0,"Mus musculus chromosome 7, clone RP23-58I15, complete sequence",".",".",".",".",".",".",".",".","pfam07182","DUF1402","Protein of unknown function (DUF1402). This family consists of several hypothetical bacterial proteins of around 310 residues in length. Members of this family seem to be found exclusively in Agrobacterium, Rhizobium and Brucella species. The function of this family is unknown.",".",".",".",".","."]
["ENSRNOG00000069828",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","ENSRNOG00000069828","protein_coding","chr4:97265223-97308495:+","gi|302151243|gb|ADK97500.1|",446,{"v":2e-53,"d":"2.00E-53"},"immunoglobulin kappa light chain variable region [Mus musculus]","gi|672050041|ref|XM_008763016.1|",292,{"v":7e-150,"d":"7.00E-150"},"PREDICTED: Rattus norvegicus uncharacterized LOC103690612 (LOC103690612), transcript variant X2, mRNA","P06310",150,{"v":8e-45,"d":"8.00E-45"},"Immunoglobulin kappa variable 2-30",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000070222",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","ENSRNOG00000070222","protein_coding","chr2:51918044-51918968:-","gi|672015452|ref|XP_008773297.1|",630,{"v":5E-80,"d":"5.00E-80"},"PREDICTED: annexin-2 receptor-like [Rattus norvegicus]","gi|672015451|ref|XM_008775075.1|",452,0,"PREDICTED: Rattus norvegicus annexin-2 receptor-like (LOC103695097), mRNA",".",".",".",".",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.",".",".",".",".","."]
["ENSRNOG00000070279",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","ENSRNOG00000070279","protein_coding","chr3:75123279-75124251:+","gi|470632967|ref|XP_004322437.1|",505,{"v":6e-63,"d":"6.00E-63"},"PREDICTED: copine-8-like, partial [Tursiops truncatus]","gi|371905553|emb|AM747284.1|",293,{"v":1E-150,"d":"1.00E-150"},"Rattus norvegicus mRNA for copine 8 protein (Cpne8 gene)",".",".",".",".",".",".",".",".","pfam07002","Copine","Copine. This family represents a conserved region approximately 180 residues long within eukaryotic copines. Copines are Ca(2+)-dependent phospholipid-binding proteins that are thought to be involved in membrane-trafficking, and may also be involved in cell division and growth.",".",".",".",".","."]
["ENSRNOG00000070509",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","ENSRNOG00000070509","protein_coding","chr9:94376174-94389174:+","gi|564312072|ref|XP_006227022.1|",2002,0,"PREDICTED: galactose-3-O-sulfotransferase 2 [Rattus norvegicus]","gi|672024336|ref|XM_006226960.2|",2420,0,"PREDICTED: Rattus norvegicus galactose-3-O-sulfotransferase 2 (Gal3st2), mRNA","Q6XQH0",672,0,"Galactose-3-O-sulfotransferase 2",".",".",".",".","pfam06990","Gal-3-0_sulfotr","Galactose-3-O-sulfotransferase. This family consists of several mammalian galactose-3-O-sulfotransferase proteins. Gal-3-O-sulfotransferase is thought to play a critical role in 3'-sulfation of N-acetyllactosamine in both O- and N-glycans.",".",".",".",".","."]
["ENSRNOG00000070729",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","ENSRNOG00000070729","protein_coding","chr6:135005507-135005977:-","gi|149034302|gb|EDL89052.1|",556,{"v":8e-71,"d":"8.00E-71"},"rCG21059, partial [Rattus norvegicus]","gi|150187987|emb|AM293751.1|",279,{"v":8e-143,"d":"8.00E-143"},"Rattus norvegicus partial mRNA for immunoglobulin heavy chain variable region (Ighv gene), clone UV-IL2.54","P01751",176,{"v":2E-55,"d":"2.00E-55"},"Ig heavy chain V region B1-8/186-2",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000070781",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","ENSRNOG00000070781","protein_coding","chr2:177904797-177905027:+","gi|112362181|gb|AAI20759.1|",158,{"v":2E-12,"d":"2.00E-12"},"Sprr2f protein, partial [Mus musculus]","gi|672043278|ref|XM_006232816.2|",231,{"v":2E-116,"d":"2.00E-116"},"PREDICTED: Rattus norvegicus small proline-rich protein 2I-like (LOC102550598), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam10321","7TM_GPCR_Srt","Serpentine type 7TM GPCR chemoreceptor Srt. Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srt is a member of the Srg superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.",".",".",".",".","."]
["ENSRNOG00000070816",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","ENSRNOG00000070816","protein_coding","chr6:135494379-135494919:-","gi|149034304|gb|EDL89054.1|",608,{"v":2E-78,"d":"2.00E-78"},"rCG63169, partial [Rattus norvegicus]","gi|204729|gb|J00744.1|RATIGEM",370,0,"rat ig epsilon heavy chain, complete coding region and 3' ut, mrna","P01805",236,{"v":8E-79,"d":"8.00E-79"},"Ig heavy chain V region IR2",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000070884",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","ENSRNOG00000070884","snoRNA","chr1:85323022-85323143:-",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","pfam11756","YgbA_NO","Nitrous oxide-stimulated promoter. The function of ygaB is not known but it is a promoter that is stimulated by the presence of nitrous oxide. It is regulated by the gene-product of the bacterial nsrR gene.",".",".",".",".","."]
["ENSRNOG00000070921",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","ENSRNOG00000070921","protein_coding","chr2:211521217-211526885:+","gi|625227801|ref|XP_003514958.2|",249,{"v":2E-19,"d":"2.00E-19"},"PREDICTED: protein transport protein Sec24D isoform X1 [Cricetulus griseus]","gi|827342575|ref|NM_001309453.1|",821,0,"Rattus norvegicus SEC24 homolog D, COPII coat complex component (Sec24d), mRNA","O94855",96.3,{"v":1e-19,"d":"1.00E-19"},"Protein transport protein Sec24D",".",".",".",".","pfam04987","PigN","Phosphatidylinositolglycan class N (PIG-N). Phosphatidylinositolglycan class N (PIG-N) is a mammalian homologue of the yeast protein MCD4P and is expressed in the endoplasmic reticulum. PIG-N is essential for glycosylphosphatidylinositol anchor synthesis. Glycosylphosphatidylinositol (GPI)-anchored proteins are cell surface-localized proteins that serve many important cellular functions.",".",".",".",".","."]
["ENSRNOG00000071008",0,0.032165219,5,0.322809298,0.099641551,-3.327108714,0.040314257,0.019198466,"down","yes","ENSRNOG00000071008","protein_coding","chr18:1900890-1902758:-","gi|564375465|ref|XP_213532.4|",478,{"v":1E-56,"d":"1.00E-56"},"PREDICTED: UBA-like domain-containing protein 2 isoform X2 [Rattus norvegicus]","gi|672070066|ref|XM_213532.7|",295,{"v":1e-151,"d":"1.00E-151"},"PREDICTED: Rattus norvegicus UBA-like domain containing 2 (Ubald2), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam15449","Retinal","Retinal protein. This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.",".",".",".",".","."]
["ENSRNOG00000065945",12,0.771965258,24,1.549484632,0.498207754,-1.005180619,0.042400626,0.020061561,"down","yes","ENSRNOG00000065945","lncRNA","chr5:160567024-160568342:-",".",".",".",".","gi|354795025|gb|JN959526.1|",327,{"v":5e-169,"d":"5.00E-169"},"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Gpr157:tm1e(KOMP)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSRNOG00000018598",10,0.643304382,21,1.355799053,0.474483575,-1.075569947,0.044770763,0.021088634,"down","yes","Ankrd1","protein_coding","chr1:233815851-233834919:-","gi|672040220|ref|XP_008758585.1|",1748,0,"PREDICTED: ankyrin repeat domain-containing protein 1 isoform X1 [Rattus norvegicus]","gi|672040219|ref|XM_008760363.1|",1815,0,"PREDICTED: Rattus norvegicus ankyrin repeat domain 1 (Ankrd1), transcript variant X1, mRNA","Q8R560",570,0,"Ankyrin repeat domain-containing protein 1","TVN1399",81.6,{"v":2E-16,"d":"2.00E-16"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;GO:0010976|positive regulation of neuron projection development;GO:0035914|skeletal muscle cell differentiation;GO:0035994|response to muscle stretch;GO:0043065|positive regulation of apoptotic process;GO:0043517|positive regulation of DNA damage response, signal transduction by p53 class mediator;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0050714|positive regulation of protein secretion;GO:0055008|cardiac muscle tissue morphogenesis;GO:0070528|protein kinase C signaling;GO:0071222|cellular response to lipopolysaccharide;GO:0071260|cellular response to mechanical stimulus;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071407|cellular response to organic cyclic compound;GO:0071456|cellular response to hypoxia;GO:0071466|cellular response to xenobiotic stimulus;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:2000279|negative regulation of DNA biosynthetic process;","GO:0001650|fibrillar center;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0030016|myofibril;GO:0031674|I band;GO:0032991|protein-containing complex;","GO:0002039|p53 binding;GO:0003677|DNA binding;GO:0003712|transcription coregulator activity;GO:0003713|transcription coactivator activity;GO:0003714|transcription corepressor activity;GO:0005515|protein binding;GO:0031432|titin binding;GO:0042826|histone deacetylase binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;GO:0070412|R-SMAD binding;","K21433","ANKRD1; ankyrin repeat domain-containing protein 1"]
["ENSRNOG00000021670",10,0.643304382,21,1.355799053,0.474483575,-1.075569947,0.044770763,0.021088634,"down","yes","Frem2","protein_coding","chr2:137602784-137740785:-","gi|350534782|ref|NP_001232907.1|",16646,0,"FRAS1-related extracellular matrix protein 2 precursor [Rattus norvegicus]","gi|350534781|ref|NM_001245978.1|",9810,0,"Rattus norvegicus Fras1 related extracellular matrix protein 2 (Frem2), mRNA","Q6NVD0",6143,0,"FRAS1-related extracellular matrix protein 2",".",".",".",".","pfam03160","Calx-beta","Calx-beta domain.","GO:0001654|eye development;GO:0001822|kidney development;GO:0002009|morphogenesis of an epithelium;GO:0007154|cell communication;GO:0007155|cell adhesion;GO:0007507|heart development;GO:0042733|embryonic digit morphogenesis;GO:0048839|inner ear development;","GO:0005604|basement membrane;GO:0016021|integral component of membrane;",".","K23380","FREM1_2; FRAS1-related extracelluar matrix protein 1/2"]
["ENSRNOG00000025261",6,0.385982629,15,0.968427895,0.398566203,-1.327108714,0.045129224,0.021248719,"down","yes","ENSRNOG00000025261","protein_coding","chr5:157624396-157655177:+","gi|564306414|ref|XP_006225663.1|",2723,0,"PREDICTED: zinc finger protein 501-like isoform X1 [Rattus norvegicus]","gi|672020092|ref|XM_006225601.2|",1881,0,"PREDICTED: Rattus norvegicus hypothetical protein LOC691254 (LOC691254), transcript variant X2, mRNA","Q6PDB4",375,{"v":1E-119,"d":"1.00E-119"},"Zinc finger protein 880",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006357|regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0046872|metal ion binding;",".","."]
["ENSRNOG00000068131",6,0.385982629,15,0.968427895,0.398566203,-1.327108714,0.045129224,0.021248719,"down","yes","ENSRNOG00000068131","protein_coding","chr3:163859125-163861616:+","gi|672017843|ref|XP_008773854.1|",1925,0,"PREDICTED: zinc finger protein 260-like, partial [Rattus norvegicus]","gi|378744249|gb|AC246509.4|",1766,0,"Rattus norvegicus Y Chr BAC RNECO-104M15 (Amplicon Express Rat SHR-Akr (EcoR1 Digest) BAC library) complete sequence","E9QAG8",499,{"v":1E-166,"d":"1.00E-166"},"Zinc finger protein 431","SPAC144.09c",126,{"v":3e-30,"d":"3.00E-30"},"COG5048","pfam02994","Transposase_22","L1 transposable element.",".",".",".",".","."]
["ENSRNOG00000068322",6,0.385982629,15,0.968427895,0.398566203,-1.327108714,0.045129224,0.021248719,"down","yes","ENSRNOG00000068322","lncRNA","chrX:14254684-14266298:+",".",".",".",".","gi|672032061|ref|XM_006227284.2|",203,{"v":2E-100,"d":"2.00E-100"},"PREDICTED: Rattus norvegicus FtsJ RNA methyltransferase homolog 1 (E. coli) (Ftsj1), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam09234","DUF1963","Domain of unknown function (DUF1963). This domain is found in a set of hypothetical bacterial proteins. Its exact function has not, as yet, been described.",".",".",".",".","."]
["ENSRNOG00000002154",3,0.192991315,10,0.645618597,0.298924652,-1.742146214,0.04567661,0.021486966,"down","yes","Mepe","protein_coding","chr14:5420635-5432183:-","gi|564382780|ref|XP_006250696.1|",2114,0,"PREDICTED: matrix extracellular phosphoglycoprotein isoform X1 [Rattus norvegicus]","gi|672075832|ref|XM_006250634.2|",1614,0,"PREDICTED: Rattus norvegicus matrix extracellular phosphoglycoprotein (Mepe), transcript variant X1, mRNA","Q9NQ76",301,{"v":3e-93,"d":"3.00E-93"},"Matrix extracellular phosphoglycoprotein",".",".",".",".","pfam07175","Osteoregulin","Osteoregulin. This family represents a conserved region approximately 180 residues long within osteoregulin, a bone-remodelling protein expressed highly in osteocytes within trabecular and cortical bone. A conserved RGD motif is found towards the C-terminal end of this region, and this is potentially involved in integrin recognition.","GO:0030502|negative regulation of bone mineralization;GO:0031214|biomineral tissue development;GO:0046850|regulation of bone remodeling;","GO:0005576|extracellular region;GO:0031012|extracellular matrix;","GO:1990430|extracellular matrix protein binding;",".","."]
["ENSRNOG00000002501",3,0.192991315,10,0.645618597,0.298924652,-1.742146214,0.04567661,0.021486966,"down","yes","Ddx3y","protein_coding","chr13:98520201-98524176:+","gi|157819755|ref|NP_001102328.1|",2682,0,"uncharacterized protein LOC364073 [Rattus norvegicus]","gi|157819754|ref|NM_001108858.1|",3170,0,"Rattus norvegicus DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked (Ddx3y), mRNA","P16381",1025,0,"Putative ATP-dependent RNA helicase Pl10",".",".",".",".","pfam00270","DEAD","DEAD/DEAH box helicase. Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolizm, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.","GO:0007276|gamete generation;GO:0007283|spermatogenesis;GO:0030154|cell differentiation;","GO:0005634|nucleus;GO:0043186|P granule;","GO:0003723|RNA binding;GO:0003724|RNA helicase activity;GO:0005524|ATP binding;GO:0016787|hydrolase activity;","K11594","DDX3X, bel; ATP-dependent RNA helicase DDX3X [EC:3.6.4.13]"]
["ENSRNOG00000007431",3,0.192991315,10,0.645618597,0.298924652,-1.742146214,0.04567661,0.021486966,"down","yes","Shroom1","protein_coding","chr10:37621723-37631256:+","gi|564312725|ref|XP_006220734.1|",3386,0,"PREDICTED: protein Shroom1 [Rattus norvegicus]","gi|672024761|ref|XM_006220672.2|",2796,0,"PREDICTED: Rattus norvegicus shroom family member 1 (Shroom1), mRNA","Q5SX79",1028,0,"Protein Shroom1",".",".",".",".","pfam08687","ASD2","Apx/Shroom domain ASD2. This region is found in the actin binding protein Shroom which mediates apical contriction in epithelial cells and is required for neural tube closure.","GO:0000902|cell morphogenesis;GO:0007015|actin filament organization;GO:0051017|actin filament bundle assembly;","GO:0005874|microtubule;GO:0005912|adherens junction;GO:0016324|apical plasma membrane;GO:0030864|cortical actin cytoskeleton;GO:0043296|apical junction complex;","GO:0045159|myosin II binding;GO:0051015|actin filament binding;","K18625","SHROOM; protein Shroom"]
["ENSRNOG00000042867",3,0.192991315,10,0.645618597,0.298924652,-1.742146214,0.04567661,0.021486966,"down","yes","Cfap97d2","protein_coding","chr16:75802434-75826853:-","gi|568953371|ref|XP_006508884.1|",721,{"v":2E-92,"d":"2.00E-92"},"PREDICTED: uncharacterized protein LOC403185 isoform X2 [Mus musculus]","gi|672029565|ref|XR_341235.2|",840,0,"PREDICTED: Rattus norvegicus hypothetical protein LOC688801 (LOC688801), transcript variant X1, misc_RNA",".",".",".",".",".",".",".",".","pfam13879","KIAA1430","KIAA1430 homologue. This is a family of KIAA1430 homologues. The function is not known.",".",".",".",".","."]
["ENSRNOG00000054955",3,0.192991315,10,0.645618597,0.298924652,-1.742146214,0.04567661,0.021486966,"down","yes","Adgra1","protein_coding","chr1:194629726-194672550:+","gi|589949984|ref|XP_006987648.1|",2657,0,"PREDICTED: probable G-protein coupled receptor 123 [Peromyscus maniculatus bairdii]","gi|672038981|ref|XM_008760017.1|",3681,0,"PREDICTED: Rattus norvegicus G protein-coupled receptor 123 (Gpr123), transcript variant X2, mRNA","Q8C4G9",996,0,"Adhesion G protein-coupled receptor A1",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0007186|G protein-coupled receptor signaling pathway;","GO:0014069|postsynaptic density;GO:0016021|integral component of membrane;GO:0098978|glutamatergic synapse;","GO:0004930|G protein-coupled receptor activity;","K08460","ADGRA1, GPR123; adhesion G protein-coupled receptor A1"]
["ENSRNOG00000016872",8,0.514643505,18,1.162113474,0.442851337,-1.175105621,0.046025042,0.021634836,"down","yes","Plppr4","protein_coding","chr2:205371322-205412302:-","gi|325197225|ref|NP_001001508.2|",3612,0,"phospholipid phosphatase-related protein type 4 [Rattus norvegicus]","gi|325197224|ref|NM_001001508.2|",4736,0,"Rattus norvegicus phospholipid phosphatase related 4 (Plppr4), mRNA","Q7TME0",1390,0,"Phospholipid phosphatase-related protein type 4",".",".",".",".","pfam01569","PAP2","PAP2 superfamily. This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidizing halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.","GO:0006644|phospholipid metabolic process;GO:0007165|signal transduction;GO:0007409|axonogenesis;GO:0046839|phospholipid dephosphorylation;GO:0048839|inner ear development;","GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0098978|glutamatergic synapse;GO:0099061|integral component of postsynaptic density membrane;","GO:0008195|phosphatidate phosphatase activity;GO:0042577|lipid phosphatase activity;GO:0052642|lysophosphatidic acid phosphatase activity;","K19582","LPPR3_4; lipid phosphate phosphatase-related protein type 3/4"]
["ENSRNOG00000042327",8,0.514643505,18,1.162113474,0.442851337,-1.175105621,0.046025042,0.021634836,"down","yes","Mroh2b","protein_coding","chr2:54003862-54063984:+","gi|672041681|ref|XP_008759027.1|",8136,0,"PREDICTED: maestro heat-like repeat-containing protein family member 2B isoform X2 [Rattus norvegicus]","gi|672041680|ref|XM_008760805.1|",4758,0,"PREDICTED: Rattus norvegicus maestro heat-like repeat family member 2B (Mroh2b), transcript variant X2, mRNA","Q7M6Y6",2973,0,"Maestro heat-like repeat-containing protein family member 2B",".",".",".",".","pfam14910","MMS22L_N","S-phase genomic integrity recombination mediator, N-terminal. MMS22L (Methyl methanesulfonate-sensitivity protein 22-like) is found in yeast, plants and vertebrates, and is integrally concerned with DNA forking and repair mechanisms during replication. MMS22L complexes with TONSL and this complex accumulates at regions of ssDNA associated with distressed replication forks or at processed DNA breaks. Its depletion results in high levels of endogenous DNA double-strand breaks caused by an inability to complete DNA synthesis after replication fork collapse. Thus the complex mediates recovery from replication stress and homologous recombination in vertebrates, yeasts and plants. This family is the more N-terminal region of the proteins.",".",".",".",".","."]
["ENSRNOG00000052319",8,0.514643505,18,1.162113474,0.442851337,-1.175105621,0.046025042,0.021634836,"down","yes","AABR07004881.1","pseudogene","chr1:154618281-154618592:+","gi|74211033|dbj|BAE37618.1|",146,{"v":2e-10,"d":"2.00E-10"},"unnamed protein product [Mus musculus]","gi|672038083|ref|XM_006229793.2|",210,{"v":1e-104,"d":"1.00E-104"},"PREDICTED: Rattus norvegicus phosphoglucomutase 2-like 1 (Pgm2l1), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam04749","PLAC8","PLAC8 family. This family includes the Placenta-specific gene 8 protein.",".",".",".",".","."]
["ENSRNOG00000068366",8,0.514643505,18,1.162113474,0.442851337,-1.175105621,0.046025042,0.021634836,"down","yes","U6","snRNA","chr3:16029879-16029985:+","gi|795259358|ref|XP_011810959.1|",127,4e-08,"PREDICTED: LOW QUALITY PROTEIN: actin, alpha skeletal muscle-like [Colobus angolensis palliatus]","gi|354785713|gb|JN950214.1|",80,{"v":8e-33,"d":"8.00E-33"},"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Kctd13:tm1a(EUCOMM)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam08903","DUF1846","Domain of unknown function (DUF1846). This family of proteins are functionally uncharacterized. Some members of the family are annotated as ATP-dependent peptidases. However, we can find no support for this annotation.",".",".",".",".","."]
["ENSRNOG00000070553",8,0.514643505,18,1.162113474,0.442851337,-1.175105621,0.046025042,0.021634836,"down","yes","Gltpd2","protein_coding","chr10:55233571-55235233:+","gi|198041781|ref|NP_001108502.1|",1467,0,"glycolipid transfer protein domain-containing protein 2 [Rattus norvegicus]","gi|198041780|ref|NM_001115030.1|",1367,0,"Rattus norvegicus glycolipid transfer protein domain containing 2 (Gltpd2), mRNA","Q8K0R6",464,{"v":1e-160,"d":"1.00E-160"},"Glycolipid transfer protein domain-containing protein 2",".",".",".",".","pfam08718","GLTP","Glycolipid transfer protein (GLTP). GLTP is a cytosolic protein that catalyses the intermembrane transfer of glycolipids.",".",".",".",".","."]
["ENSRNOG00000071088",8,0.514643505,18,1.162113474,0.442851337,-1.175105621,0.046025042,0.021634836,"down","yes","ENSRNOG00000071088","lncRNA","chr5:141366115-141370274:+","gi|149048372|gb|EDM00948.1|",136,2e-06,"rCG62706 [Rattus norvegicus]","gi|22552760|emb|AL607086.19|",420,0,"Mouse DNA sequence from clone RP23-269B7 on chromosome 4, complete sequence",".",".",".",".",".",".",".",".","pfam01867","Cas_Cas1","CRISPR associated protein Cas1. Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein. Cas1 may be involved in linking DNA segments to CRISPR.",".",".",".",".","."]
["ENSRNOG00000001644",1,0.064330438,6,0.387371158,0.166069251,-2.59014312,0.046935299,0.021968695,"down","yes","Tmem30c","protein_coding","chr11:43241508-43258427:+","gi|157786824|ref|NP_001099359.1|",1691,0,"cell cycle control protein 50C [Rattus norvegicus]","gi|672070848|ref|XM_008768632.1|",1219,0,"PREDICTED: Rattus norvegicus transmembrane protein 30C (Tmem30c), transcript variant X1, mRNA","Q9D4D7",603,0,"Cell cycle control protein 50C","YCR094w",126,{"v":2e-31,"d":"2.00E-31"},"COG5035","pfam03381","CDC50","LEM3 (ligand-effect modulator 3) family / CDC50 family. Members of this family have been predicted to contain transmembrane helices. The family member LEM3 is a ligand-effect modulator, mutation of which increases glucocorticoid receptor activity in response to dexamethasone and also confers increased activity on other intracellular receptors including the progesterone, oestrogen and mineralocorticoid receptors. LEM3 is thought to affect a downstream step in the glucocorticoid receptor pathway. Factors that modulate ligand responsiveness are likely to contribute to the context-specific actions of the glucocorticoid receptor in mammalian cells. The products of genes YNR048w, YNL323w and YCR094w (CDC50) show redundancy of function and are involved in regulation of transcription via CDC39. CDC39 (also known as NOT1) is normally a negative regulator of transcription either by affecting the general RNA polymerase II machinery or by altering chromatin structure. One function of CDC39 is to block activation of the mating response pathway in the absence of pheromone, and mutation causes arrest in G1 by activation of the pathway. It may be that the cold-sensitive arrest in G1 noticed in CDC50 mutants may be due to inactivation of CDC39. The effects of LEM3 on glucocorticoid receptor activity may also be due to effects on transcription via CDC39.","GO:0045332|phospholipid translocation;","GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000002202",1,0.064330438,6,0.387371158,0.166069251,-2.59014312,0.046935299,0.021968695,"down","yes","Sowahb","protein_coding","chr14:15029395-15031698:+","gi|27693471|ref|XP_223228.1|",3447,0,"PREDICTED: ankyrin repeat domain-containing protein SOWAHB [Rattus norvegicus]","gi|564316741|ref|XM_001070624.3|",2304,0,"PREDICTED: Rattus norvegicus sosondowah ankyrin repeat domain family member B (Sowahb), mRNA",".",".",".",".",".",".",".",".","pfam12796","Ank_2","Ankyrin repeats (3 copies).",".",".",".",".","."]
["ENSRNOG00000013312",1,0.064330438,6,0.387371158,0.166069251,-2.59014312,0.046935299,0.021968695,"down","yes","Kcnt2","protein_coding","chr13:51664686-52056987:+","gi|564380929|ref|XP_006250004.1|",5825,0,"PREDICTED: potassium channel subfamily T member 2 isoform X2 [Rattus norvegicus]","gi|672074120|ref|XM_006249942.2|",3092,0,"PREDICTED: Rattus norvegicus potassium channel, subfamily T, member 2 (Kcnt2), transcript variant X2, mRNA","Q6UVM4",2240,0,"Potassium channel subfamily T member 2","MJ1357",65.9,{"v":2e-10,"d":"2.00E-10"},"COG1226","pfam03493","BK_channel_a","Calcium-activated BK potassium channel alpha subunit.","GO:0006813|potassium ion transport;GO:0071805|potassium ion transmembrane transport;GO:0097623|potassium ion export across plasma membrane;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0005228|intracellular sodium activated potassium channel activity;GO:0005267|potassium channel activity;GO:0005524|ATP binding;GO:0015271|outward rectifier potassium channel activity;GO:0070089|chloride-activated potassium channel activity;","K04947","KCNT2, KNA1.2; potassium channel subfamily T member 2"]
["ENSRNOG00000014409",1,0.064330438,6,0.387371158,0.166069251,-2.59014312,0.046935299,0.021968695,"down","yes","Myl7","protein_coding","chr14:80779776-80783244:-","gi|564384290|ref|XP_006251278.1|",816,{"v":2e-102,"d":"2.00E-102"},"PREDICTED: myosin regulatory light chain 2, atrial isoform isoform X1 [Rattus norvegicus]","gi|171846742|gb|BC161995.1|",1482,0,"Rattus norvegicus myosin, light chain 7, regulatory, mRNA (cDNA clone MGC:187830 IMAGE:9034230), complete cds","Q9QVP4",317,{"v":3E-103,"d":"3.00E-103"},"Myosin regulatory light chain 2, atrial isoform","SPAC3A12.14",87,{"v":8e-19,"d":"8.00E-19"},"COG5126","pfam13499","EF-hand_7","EF-hand domain pair.",".","GO:0031672|A band;GO:0043197|dendritic spine;","GO:0005509|calcium ion binding;","K12754","MYL7; myosin regulatory light chain 7"]
["ENSRNOG00000014519",1,0.064330438,6,0.387371158,0.166069251,-2.59014312,0.046935299,0.021968695,"down","yes","Slc35g3","protein_coding","chr10:54479770-54481748:-","gi|625185573|ref|XP_003497230.2|",1555,0,"PREDICTED: solute carrier family 35 member G6 [Cricetulus griseus]","gi|189083757|ref|NM_001127658.1|",1304,0,"Rattus norvegicus solute carrier family 35, member G3 (Slc35g3), mRNA","B0K004",572,0,"Solute carrier family 35 member G3",".",".",".",".","pfam00892","EamA","EamA-like transporter family. This family includes many hypothetical membrane proteins of unknown function.  Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000018083",1,0.064330438,6,0.387371158,0.166069251,-2.59014312,0.046935299,0.021968695,"down","yes","AABR07004876.1","protein_coding","chr1:154141584-154142717:+","gi|149062132|gb|EDM12555.1|",614,{"v":3E-79,"d":"3.00E-79"},"rCG47344, isoform CRA_b [Rattus norvegicus]","gi|672020774|ref|XM_001080119.5|",335,{"v":6e-174,"d":"6.00E-174"},"PREDICTED: Rattus norvegicus similar to Finkel-Biskis-Reilly murine sarcoma virusubiquitously expressed (LOC687780), mRNA",".",".",".",".",".",".",".",".","pfam04758","Ribosomal_S30","Ribosomal protein S30.",".",".",".",".","."]
["ENSRNOG00000019176",1,0.064330438,6,0.387371158,0.166069251,-2.59014312,0.046935299,0.021968695,"down","yes","Kcne5","protein_coding","chrX:105930398-105931013:-","gi|26380608|dbj|BAC25441.1|",416,{"v":5e-59,"d":"5.00E-59"},"unnamed protein product [Mus musculus]","gi|155369687|ref|NM_001101003.1|",616,0,"Rattus norvegicus potassium voltage-gated channel subfamily E regulatory subunit 5 (Kcne5), mRNA","Q9QZ26",185,{"v":7e-58,"d":"7.00E-58"},"Potassium voltage-gated channel subfamily E regulatory beta subunit 5",".",".",".",".","pfam07271","Cytadhesin_P30","Cytadhesin P30/P32. This family consists of several Mycoplasma species specific Cytadhesin P32 and P30 proteins. P30 has been found to be membrane associated and localized on the tip organelle. It is thought that it is important in cytadherence and virulence.","GO:0008016|regulation of heart contraction;GO:0008150|biological_process;GO:0060048|cardiac muscle contraction;GO:0060306|regulation of membrane repolarization;GO:0060307|regulation of ventricular cardiac muscle cell membrane repolarization;GO:0060372|regulation of atrial cardiac muscle cell membrane repolarization;GO:0086005|ventricular cardiac muscle cell action potential;GO:0086011|membrane repolarization during action potential;GO:0086014|atrial cardiac muscle cell action potential;GO:0086091|regulation of heart rate by cardiac conduction;GO:0097623|potassium ion export across plasma membrane;GO:0098915|membrane repolarization during ventricular cardiac muscle cell action potential;GO:1901379|regulation of potassium ion transmembrane transport;GO:1901380|negative regulation of potassium ion transmembrane transport;GO:1901381|positive regulation of potassium ion transmembrane transport;GO:1902260|negative regulation of delayed rectifier potassium channel activity;GO:1903765|negative regulation of potassium ion export across plasma membrane;GO:2001257|regulation of cation channel activity;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0008076|voltage-gated potassium channel complex;","GO:0003674|molecular_function;GO:0005249|voltage-gated potassium channel activity;GO:0005251|delayed rectifier potassium channel activity;GO:0015459|potassium channel regulator activity;GO:0044325|ion channel binding;GO:0086008|voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization;GO:1902282|voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization;","K04895","KCNE1L; potassium voltage-gated channel Isk-related subfamily E member 1-like"]
["ENSRNOG00000020625",1,0.064330438,6,0.387371158,0.166069251,-2.59014312,0.046935299,0.021968695,"down","yes","ENSRNOG00000020625","protein_coding","chr15:29871335-29873926:+","gi|25282393|ref|NP_742041.1|",1197,{"v":9e-163,"d":"9.00E-163"},"mast cell protease 2 precursor [Rattus norvegicus]","gi|25282392|ref|NM_172044.1|",741,0,"Rattus norvegicus mast cell protease 2 (Mcpt2), mRNA","P00770",465,{"v":3e-164,"d":"3.00E-164"},"Mast cell protease 2","mlr3307",72.8,{"v":1E-13,"d":"1.00E-13"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;","GO:0005615|extracellular space;","GO:0004252|serine-type endopeptidase activity;","K08662","MCPT2; mast cell peptidase 2 [EC:3.4.21.-]"]
["ENSRNOG00000032924",1,0.064330438,6,0.387371158,0.166069251,-2.59014312,0.046935299,0.021968695,"down","yes","AABR07064753.1","protein_coding","chr6:89822951-89842880:+","gi|31982864|ref|NP_031538.2|",337,{"v":1E-35,"d":"1.00E-35"},"ATPase inhibitor, mitochondrial precursor [Mus musculus]","gi|672020806|ref|XR_601478.1|",716,0,"PREDICTED: Rattus norvegicus similar to ATPase inhibitory factor 1 (RGD1559545), ncRNA","O35143",134,{"v":5e-37,"d":"5.00E-37"},"ATPase inhibitor, mitochondrial",".",".",".",".","pfam04568","IATP","Mitochondrial ATPase inhibitor, IATP. ATP synthase inhibitor prevents the enzyme from switching to ATP hydrolysis during collapse of the electrochemical gradient, for example during oxygen deprivation ATP synthase inhibitor forms a one to one complex with the F1 ATPase, possibly by binding at the alpha-beta interface. It is thought to inhibit ATP synthesis by preventing the release of ATP. The minimum inhibitory region for bovine inhibitor is from residues 39 to 72. The inhibitor has two oligomeric states, dimer (the active state) and tetramer. At low pH, the inhibitor forms a dimer via antiparallel coiled coil interactions between the C terminal regions of two monomers. At high pH, the inhibitor forms tetramers and higher oligomers by coiled coil interactions involving the N terminus and inhibitory region, thus preventing the inhibitory activity.",".",".",".",".","."]
["ENSRNOG00000036819",1,0.064330438,6,0.387371158,0.166069251,-2.59014312,0.046935299,0.021968695,"down","yes","Hspb9","protein_coding","chr10:85641284-85641929:+","gi|157819189|ref|NP_001102305.1|",1071,{"v":3e-146,"d":"3.00E-146"},"heat shock protein beta-9 [Rattus norvegicus]","gi|157819188|ref|NM_001108835.1|",646,0,"Rattus norvegicus heat shock protein family B (small) member 9 (Hspb9), mRNA","Q9DAM3",266,{"v":8e-89,"d":"8.00E-89"},"Heat shock protein beta-9",".",".",".",".","pfam00011","HSP20","Hsp20/alpha crystallin family.",".","GO:0005634|nucleus;GO:0005737|cytoplasm;",".","K09547","HSPB9; heat shock protein beta-9"]
["ENSRNOG00000042407",1,0.064330438,6,0.387371158,0.166069251,-2.59014312,0.046935299,0.021968695,"down","yes","Obp2a","protein_coding","chr3:8505990-8509269:+","gi|189458872|ref|NP_001121611.1|",829,{"v":1e-109,"d":"1.00E-109"},"odorant binding protein 2A precursor [Rattus norvegicus]","gi|402693461|ref|NM_001128139.2|",698,0,"Rattus norvegicus odorant binding protein 2A (Obp2a), mRNA","Q8K1H9",222,{"v":3e-71,"d":"3.00E-71"},"Odorant-binding protein 2a",".",".",".",".","pfam00061","Lipocalin","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.","GO:0008286|insulin receptor signaling pathway;GO:0010906|regulation of glucose metabolic process;GO:0032000|positive regulation of fatty acid beta-oxidation;GO:0042593|glucose homeostasis;GO:0045721|negative regulation of gluconeogenesis;GO:0051055|negative regulation of lipid biosynthetic process;","GO:0005615|extracellular space;","GO:0036094|small molecule binding;","K25352","OBP2; odorant-binding protein 2"]
["ENSRNOG00000042634",1,0.064330438,6,0.387371158,0.166069251,-2.59014312,0.046935299,0.021968695,"down","yes","Serpina12","protein_coding","chr6:122952552-122967271:-","gi|158341658|ref|NP_620180.2|",2148,0,"serpin A12 precursor [Rattus norvegicus]","gi|158341657|ref|NM_138825.2|",1487,0,"Rattus norvegicus serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 (Serpina12), mRNA","Q8R4Z1",823,0,"Serpin A12","all0778",158,{"v":2e-42,"d":"2.00E-42"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0006006|glucose metabolic process;GO:0010951|negative regulation of endopeptidase activity;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0045721|negative regulation of gluconeogenesis;GO:0046628|positive regulation of insulin receptor signaling pathway;GO:0051055|negative regulation of lipid biosynthetic process;GO:0090181|regulation of cholesterol metabolic process;GO:0090207|regulation of triglyceride metabolic process;","GO:0005615|extracellular space;GO:0005886|plasma membrane;","GO:0004867|serine-type endopeptidase inhibitor activity;","K04525","SERPINA; serpin A"]
["ENSRNOG00000043562",1,0.064330438,6,0.387371158,0.166069251,-2.59014312,0.046935299,0.021968695,"down","yes","Mir1956","miRNA","chr2:227066526-227066588:+",".",".",".",".","gi|731185449|ref|NR_128672.1|",63,{"v":9e-24,"d":"9.00E-24"},"Rattus norvegicus microRNA 1956 (Mir1956), microRNA",".",".",".",".",".",".",".",".","pfam11228","DUF3027","Protein of unknown function (DUF3027). This family of proteins with unknown function appears to be restricted to Actinobacteria.",".",".",".",".","."]
["ENSRNOG00000046991",1,0.064330438,6,0.387371158,0.166069251,-2.59014312,0.046935299,0.021968695,"down","yes","RGD1565472","protein_coding","chr11:37680010-37680474:-","gi|148696235|gb|EDL28182.1|",696,{"v":5E-91,"d":"5.00E-91"},"transmembrane protein 127, isoform CRA_c, partial [Mus musculus]","gi|672025935|ref|XR_601866.1|",465,0,"PREDICTED: Rattus norvegicus similar to RIKEN cDNA 2310003P10 (RGD1565472), transcript variant X1, misc_RNA","Q8BGP5",272,{"v":2E-91,"d":"2.00E-91"},"Transmembrane protein 127",".",".",".",".","pfam13903","Claudin_2","PMP-22/EMP/MP20/Claudin tight junction. Members of this family are claudins, that form tight junctions between cells.","GO:0008285|negative regulation of cell proliferation;GO:0032006|regulation of TOR signaling;GO:0032007|negative regulation of TOR signaling;","GO:0016020|membrane;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000048706",1,0.064330438,6,0.387371158,0.166069251,-2.59014312,0.046935299,0.021968695,"down","yes","Nox1","protein_coding","chrX:97279056-97302236:-","gi|149055452|gb|EDM07036.1|",2746,0,"NADPH oxidase 1, isoform CRA_a [Rattus norvegicus]","gi|16758499|ref|NM_053683.1|",2562,0,"Rattus norvegicus NADPH oxidase 1 (Nox1), mRNA","Q9WV87",1057,0,"NADPH oxidase 1","PA0545",63.2,2e-09,"COG4097","pfam08030","NAD_binding_6","Ferric reductase NAD binding domain.","GO:0000302|response to reactive oxygen species;GO:0001525|angiogenesis;GO:0003081|regulation of systemic arterial blood pressure by renin-angiotensin;GO:0006952|defense response;GO:0007165|signal transduction;GO:0008284|positive regulation of cell proliferation;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0016477|cell migration;GO:0030198|extracellular matrix organization;GO:0042554|superoxide anion generation;GO:0042743|hydrogen peroxide metabolic process;GO:0043410|positive regulation of MAPK cascade;GO:0045726|positive regulation of integrin biosynthetic process;GO:0046330|positive regulation of JNK cascade;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0051454|intracellular pH elevation;GO:0071455|cellular response to hyperoxia;GO:0072592|oxygen metabolic process;GO:1902177|positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;GO:1990451|cellular stress response to acidic pH;GO:2000379|positive regulation of reactive oxygen species metabolic process;","GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005769|early endosome;GO:0005886|plasma membrane;GO:0030054|cell junction;GO:0042995|cell projection;GO:0043020|NADPH oxidase complex;","GO:0005515|protein binding;GO:0016174|NAD(P)H oxidase activity;GO:0016175|superoxide-generating NADPH oxidase activity;GO:0031267|small GTPase binding;GO:0046872|metal ion binding;","K08008","NOX1, MOX1; NADPH oxidase 1"]
["ENSRNOG00000049733",1,0.064330438,6,0.387371158,0.166069251,-2.59014312,0.046935299,0.021968695,"down","yes","Ankrd33","protein_coding","chr7:132225090-132227845:+","gi|672022395|ref|XP_008774826.1|",1691,0,"PREDICTED: ankyrin repeat domain-containing protein 33 [Rattus norvegicus]","gi|672022394|ref|XM_008776604.1|",1104,0,"PREDICTED: Rattus norvegicus similar to ankyrin repeat domain 33 (LOC683410), mRNA","Q8BXP5",566,0,"Photoreceptor ankyrin repeat protein",".",".",".",".","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0035914|skeletal muscle cell differentiation;GO:2000678|negative regulation of transcription regulatory region DNA binding;","GO:0005634|nucleus;GO:0005829|cytosol;",".",".","."]
["ENSRNOG00000056141",1,0.064330438,6,0.387371158,0.166069251,-2.59014312,0.046935299,0.021968695,"down","yes","Matn3","protein_coding","chr6:31748474-31768101:+","gi|157819693|ref|NP_001101483.1|",2301,0,"matrilin-3 precursor [Rattus norvegicus]","gi|157819692|ref|NM_001108013.1|",1999,0,"Rattus norvegicus matrilin 3 (Matn3), mRNA","O35701",853,0,"Matrilin-3",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0008150|biological_process;GO:0051216|cartilage development;","GO:0005575|cellular_component;GO:0031012|extracellular matrix;GO:0062023|collagen-containing extracellular matrix;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;","K19467","MATN; matrilin"]
["ENSRNOG00000058820",1,0.064330438,6,0.387371158,0.166069251,-2.59014312,0.046935299,0.021968695,"down","yes","Olr1768","protein_coding","chrX:152284725-152285663:-","gi|47576747|ref|NP_001000264.1|",1395,0,"olfactory receptor Olr1768 [Rattus norvegicus]","gi|47576746|ref|NM_001000264.1|",939,0,"Rattus norvegicus olfactory receptor 1768 (Olr1768), mRNA","Q9UGF6",283,{"v":7e-92,"d":"7.00E-92"},"Olfactory receptor 5V1",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0050911|detection of chemical stimulus involved in sensory perception of smell;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004984|olfactory receptor activity;","K04257","OLFR; olfactory receptor"]
["ENSRNOG00000064347",1,0.064330438,6,0.387371158,0.166069251,-2.59014312,0.046935299,0.021968695,"down","yes","ENSRNOG00000064347","lncRNA","chr1:138125888-138143821:-","gi|946787384|ref|XP_014403533.1|",528,{"v":4E-51,"d":"4.00E-51"},"PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC102257441 [Myotis brandtii]","gi|354781517|gb|JN946018.1|",703,0,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Fam108c:tm1e(EUCOMM)Wtsi tm2e(EUCOMM)Wtsi; transgenic","P03360",160,{"v":6e-38,"d":"6.00E-38"},"Gag-Pol polyprotein (Fragment)",".",".",".",".","pfam00665","rve","Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyses the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.",".",".",".",".","."]
["ENSRNOG00000064692",1,0.064330438,6,0.387371158,0.166069251,-2.59014312,0.046935299,0.021968695,"down","yes","Kif4b","protein_coding","chr6:120397005-120401245:+","gi|564307666|ref|XP_006225924.1|",5834,0,"PREDICTED: chromosome-associated kinesin KIF4A-like isoform X1 [Rattus norvegicus]","gi|672021055|ref|XM_006225862.2|",4145,0,"PREDICTED: Rattus norvegicus kinesin family member 4B (Kif4b), transcript variant X1, mRNA","O95239",1639,0,"Chromosome-associated kinesin KIF4A",".",".",".",".","pfam00225","Kinesin","Kinesin motor domain.",".",".",".",".","."]
["ENSRNOG00000064714",1,0.064330438,6,0.387371158,0.166069251,-2.59014312,0.046935299,0.021968695,"down","yes","ENSRNOG00000064714","protein_coding","chr8:56107172-56108094:-","gi|26338083|dbj|BAC32727.1|",260,{"v":4e-26,"d":"4.00E-26"},"unnamed protein product [Mus musculus]","gi|672076600|ref|XM_008770260.1|",208,{"v":3E-103,"d":"3.00E-103"},"PREDICTED: Rattus norvegicus EWS RNA-binding protein 1 (Ewsr1), transcript variant X4, mRNA","Q61545",103,{"v":1e-24,"d":"1.00E-24"},"RNA-binding protein EWS",".",".",".",".","pfam13440","Polysacc_synt_3","Polysaccharide biosynthesis protein.",".",".",".",".","."]
["ENSRNOG00000065569",1,0.064330438,6,0.387371158,0.166069251,-2.59014312,0.046935299,0.021968695,"down","yes","Tcte1","protein_coding","chr9:15463739-15472954:-","gi|157817121|ref|NP_001101676.1|",2473,0,"T-complex-associated testis-expressed protein 1 [Rattus norvegicus]","gi|672064341|ref|XM_006244539.2|",2697,0,"PREDICTED: Rattus norvegicus t-complex-associated testis expressed 1 (Tcte1), transcript variant X1, mRNA","A6H639",838,0,"Dynein regulatory complex subunit 5",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.",".",".",".",".","."]
["ENSRNOG00000065943",1,0.064330438,6,0.387371158,0.166069251,-2.59014312,0.046935299,0.021968695,"down","yes","ENSRNOG00000065943","lncRNA","chr8:45557004-45558944:+","gi|149041516|gb|EDL95357.1|",400,{"v":4e-45,"d":"4.00E-45"},"rCG58038 [Rattus norvegicus]","gi|672022743|ref|XM_008776699.1|",943,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102546809 (LOC102546809), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam14368","LTP_2","Probable lipid transfer. The members of this family are probably involved in lipid transfer. The family has several highly conserved cysteines, paired in various ways.",".",".",".",".","."]
["ENSRNOG00000066054",1,0.064330438,6,0.387371158,0.166069251,-2.59014312,0.046935299,0.021968695,"down","yes","Tex48","protein_coding","chr5:77017167-77033673:-","gi|672019457|ref|XP_008774209.1|",593,{"v":9e-75,"d":"9.00E-75"},"PREDICTED: uncharacterized protein LOC688893 isoform X1 [Rattus norvegicus]","gi|672019456|ref|XM_008775987.1|",722,0,"PREDICTED: Rattus norvegicus hypothetical protein LOC688893 (LOC688893), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam11054","Surface_antigen","Sporozoite TA4 surface antigen. This family of proteins is a Eukaryotic family of surface antigens. One of the better characterized members of the family is the sporulated TA4 antigen. The TA4 gene encodes a single polypeptide of 25 kDa which contains a 17 and a 8 kD polypeptide.",".",".",".",".","."]
["ENSRNOG00000066205",1,0.064330438,6,0.387371158,0.166069251,-2.59014312,0.046935299,0.021968695,"down","yes","ENSRNOG00000066205","lncRNA","chr1:60531777-60539102:-","gi|958811922|ref|XP_014687464.1|",155,1E-8,"PREDICTED: vomeronasal type-1 receptor 4-like [Equus asinus]","gi|287321824|ref|NG_015547.1|",205,{"v":3e-101,"d":"3.00E-101"},"Rattus norvegicus vomeronasal 1 receptor pseudogene 16 (Vom1r-ps16) on chromosome 1","Q8NFZ6",50.8,9e-06,"Vomeronasal type-1 receptor 2",".",".",".",".","pfam03402","V1R","Vomeronasal organ pheromone receptor family, V1R. This family represents one of two known vomeronasal organ receptor families, the V1R family.",".",".",".",".","."]
["ENSRNOG00000066906",1,0.064330438,6,0.387371158,0.166069251,-2.59014312,0.046935299,0.021968695,"down","yes","ENSRNOG00000066906","lncRNA","chr5:147551405-147558637:+","gi|344247357|gb|EGW03461.1|",142,2e-07,"hypothetical protein I79_021062 [Cricetulus griseus]","gi|21214053|emb|AL627078.10|",125,{"v":4e-56,"d":"4.00E-56"},"Mouse DNA sequence from clone RP23-138K13 on chromosome 4, complete sequence",".",".",".",".",".",".",".",".","pfam10873","DUF2668","Protein of unknown function (DUF2668). Members in this family of proteins are annotated as Cysteine and tyrosine-rich protein 1, however currently no function is known.",".",".",".",".","."]
["ENSRNOG00000067557",1,0.064330438,6,0.387371158,0.166069251,-2.59014312,0.046935299,0.021968695,"down","yes","ENSRNOG00000067557","lncRNA","chr9:111047471-111069241:-",".",".",".",".","gi|672066397|ref|XR_357343.2|",666,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102555849 (LOC102555849), ncRNA",".",".",".",".",".",".",".",".","pfam06191","DUF995","Protein of unknown function (DUF995). Family of uncharacterized Proteobacteria proteins.",".",".",".",".","."]
["ENSRNOG00000068040",1,0.064330438,6,0.387371158,0.166069251,-2.59014312,0.046935299,0.021968695,"down","yes","ENSRNOG00000068040","lncRNA","chr2:194936667-194939784:-","gi|344248885|gb|EGW04989.1|",136,4e-07,"hypothetical protein I79_003494 [Cricetulus griseus]","gi|49258281|gb|AC132405.3|",498,0,"Mus musculus BAC clone RP23-332I1 from chromosome 3, complete sequence",".",".",".",".",".",".",".",".","pfam09578","Spore_YabQ","Spore cortex protein YabQ (Spore_YabQ). This protein is predicted to span the membrane several times. It is only found in genomes of species that perform sporulation, such as Bacillus subtilis, Clostridium tetani, and other members of the Firmicutes (low-GC Gram-positive bacteria). Mutation of this sigmaE-dependent gene blocks development of the spore cortex. The length of the C-terminal region, which includes some hydrophobic regions, is variable.",".",".",".",".","."]
["ENSRNOG00000069440",1,0.064330438,6,0.387371158,0.166069251,-2.59014312,0.046935299,0.021968695,"down","yes","ENSRNOG00000069440","lncRNA","chr1:79777945-79799580:-","gi|149058973|gb|EDM09980.1|",123,1e-09,"rCG44489, partial [Rattus norvegicus]","gi|388240416|dbj|AP012456.1|",158,{"v":3e-75,"d":"3.00E-75"},"Rattus norvegicus DNA, BAC clone: RNB1-385K15, strain: F344/Stm, complete sequence",".",".",".",".",".",".",".",".","pfam00429","TLV_coat","ENV polyprotein (coat polyprotein).",".",".",".",".","."]
["ENSRNOG00000069701",1,0.064330438,6,0.387371158,0.166069251,-2.59014312,0.046935299,0.021968695,"down","yes","ENSRNOG00000069701","protein_coding","chr1:113862509-113864525:-","gi|58866022|ref|NP_001012225.1|",2567,0,"alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform 2 [Rattus norvegicus]","gi|237512960|ref|NM_001012225.2|",1336,0,"Rattus norvegicus mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A (Mgat4a), transcript variant 2, mRNA","Q5M854",993,0,"Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A",".",".",".",".","pfam04666","Glyco_transf_54","N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region. The complex-type of oligosaccharides are synthesized through elongation by glycosyltransferases after trimming of the precursor oligosaccharides transferred to proteins in the endoplasmic reticulum. N-Acetylglucosaminyltransferases (GnTs) take part in the formation of branches in the biosynthesis of complex-type sugar chains. In vertebrates, six GnTs, designated as GnT-I to -VI, which catalyse the transfer of GlcNAc to the core mannose residues of Asn-linked sugar chains, have been identified. GnT-IV (EC:2.4.1.145) catalyses the transfer of GlcNAc from UDP-GlcNAc to the GlcNAc1-2Man1-3 arm of core oligosaccharide [Gn2(22)core oligosaccharide] and forms GlcNAc1-4(GlcNAc1-2)Man1-3 structure on the core oligosaccharide (Gn3(2,4,2)core oligosaccharide). In some members the conserved region occupies all but the very for N-terminal, where there is a signal sequence on all members. For other members the conserved region does not occupy the entire protein but is still to the N-terminus of the protein.",".",".",".",".","."]
["ENSRNOG00000069786",1,0.064330438,6,0.387371158,0.166069251,-2.59014312,0.046935299,0.021968695,"down","yes","ENSRNOG00000069786","lncRNA","chr19:10237270-10248923:+","gi|556749001|ref|XP_005969939.1|",258,{"v":1e-38,"d":"1.00E-38"},"PREDICTED: guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1 [Pantholops hodgsonii]","gi|672084210|ref|XM_008772329.1|",507,0,"PREDICTED: Rattus norvegicus chemokine (C-X3-C motif) ligand 1 (Cx3cl1), transcript variant X1, mRNA","Q6TMK6",103,{"v":6e-40,"d":"6.00E-40"},"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.",".",".",".",".","."]
["ENSRNOG00000070177",1,0.064330438,6,0.387371158,0.166069251,-2.59014312,0.046935299,0.021968695,"down","yes","ENSRNOG00000070177","lncRNA","chr10:19294305-19369019:+",".",".",".",".","gi|354793367|gb|JN957868.1|",79,{"v":3e-31,"d":"3.00E-31"},"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Ccdc99:tm1e(KOMP)Wtsi; transgenic",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["ENSRNOG00000070478",1,0.064330438,6,0.387371158,0.166069251,-2.59014312,0.046935299,0.021968695,"down","yes","ENSRNOG00000070478","lncRNA","chr18:30212788-30220071:+","gi|149046183|gb|EDL99076.1|",139,1e-07,"rCG22569 [Rattus norvegicus]","gi|300360601|gb|AC240815.7|",721,0,"Rattus norvegicus Y Chr BAC RNAEX-226B09 (Amplicon Express Rat SHR-Akr BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam02337","Gag_p10","Retroviral GAG p10 protein. This family consists of various retroviral GAG (core) polyproteins and encompasses the p10 region producing the p10 protein upon proteolytic cleavage of GAG by retroviral protease. The p10 or matrix protein (MA) is associated with the virus envelope glycoproteins in most mammalian retroviruses and may be involved in virus particle assembly, transport and budding. Some of the GAG polyproteins have alternate cleavage sites leading to the production of alternative and longer cleavage products (e.g. p19) the alignment of this family only covers the approximately N-terminal (GAG) 100 amino acid region of homology to p10.",".",".",".",".","."]
["ENSRNOG00000001141",2,0.128660876,8,0.516494877,0.249103877,-2.005180619,0.049345242,0.022925726,"down","yes","Srrm4","protein_coding","chr12:39999488-40155725:+","gi|344237041|gb|EGV93144.1|",838,{"v":4e-96,"d":"4.00E-96"},"Uncharacterized protein KIAA1853-like [Cricetulus griseus]","gi|672073233|ref|XR_595365.1|",3773,0,"PREDICTED: Rattus norvegicus serine/arginine repetitive matrix 4 (Srrm4), transcript variant X2, misc_RNA","Q8BKA3",326,{"v":1e-95,"d":"1.00E-95"},"Serine/arginine repetitive matrix protein 4",".",".",".",".","pfam15230","SRRM_C","Serine/arginine repetitive matrix protein C-terminus. This domain is found near to the C-terminus of Serine/arginine repetitive matrix proteins 3 and 4.","GO:0000381|regulation of alternative mRNA splicing, via spliceosome;GO:0006397|mRNA processing;GO:0007399|nervous system development;GO:0007605|sensory perception of sound;GO:0008150|biological_process;GO:0030154|cell differentiation;GO:0043484|regulation of RNA splicing;","GO:0005575|cellular_component;GO:0005634|nucleus;","GO:0003674|molecular_function;GO:0003729|mRNA binding;GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000001622",2,0.128660876,8,0.516494877,0.249103877,-2.005180619,0.049345242,0.022925726,"down","yes","Impg2","protein_coding","chr11:44318836-44418382:-","gi|404351633|ref|NP_620788.2|",6253,0,"interphotoreceptor matrix proteoglycan 2 precursor [Rattus norvegicus]","gi|404351632|ref|NM_139088.2|",4337,0,"Rattus norvegicus interphotoreceptor matrix proteoglycan 2 (Impg2), mRNA","P70628",2410,0,"Interphotoreceptor matrix proteoglycan 2",".",".",".",".","pfam01390","SEA","SEA domain. Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.","GO:0007601|visual perception;GO:0008104|protein localization;GO:0030198|extracellular matrix organization;GO:0060042|retina morphogenesis in camera-type eye;","GO:0005576|extracellular region;GO:0016021|integral component of membrane;GO:0033165|interphotoreceptor matrix;GO:0042995|cell projection;GO:0043235|receptor complex;","GO:0005201|extracellular matrix structural constituent;GO:0005540|hyaluronic acid binding;GO:0008201|heparin binding;","K19017","IMPG2, SPACRCAN; interphotoreceptor matrix proteoglycan 2"]
["ENSRNOG00000020377",2,0.128660876,8,0.516494877,0.249103877,-2.005180619,0.049345242,0.022925726,"down","yes","Cideb","protein_coding","chr15:29252213-29256605:-","gi|564386225|ref|XP_006252064.1|",987,{"v":3e-128,"d":"3.00E-128"},"PREDICTED: cell death activator CIDE-B isoform X1 [Rattus norvegicus]","gi|672078087|ref|XM_006252002.2|",696,0,"PREDICTED: Rattus norvegicus cell death-inducing DFFA-like effector b (Cideb), transcript variant X1, mRNA","O70303",280,{"v":1E-89,"d":"1.00E-89"},"Cell death activator CIDE-B",".",".",".",".","pfam02017","CIDE-N","CIDE-N domain. This domain is found in CAD nuclease, and in ICAD, the inhibitor of CAD nuclease. The two proteins interact through this domain.","GO:0006915|apoptotic process;GO:0010942|positive regulation of cell death;GO:0031667|response to nutrient levels;GO:0038183|bile acid signaling pathway;GO:0042981|regulation of apoptotic process;GO:0090200|positive regulation of release of cytochrome c from mitochondria;GO:0097194|execution phase of apoptosis;GO:0097202|activation of cysteine-type endopeptidase activity;","GO:0005829|cytosol;GO:0048471|perinuclear region of cytoplasm;","GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000022863",2,0.128660876,8,0.516494877,0.249103877,-2.005180619,0.049345242,0.022925726,"down","yes","Lingo4","protein_coding","chr2:182014326-182040787:+","gi|157821919|ref|NP_001102659.1|",2942,0,"leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 4 [Rattus norvegicus]","gi|157821918|ref|NM_001109189.1|",6527,0,"Rattus norvegicus leucine rich repeat and Ig domain containing 4 (Lingo4), mRNA","Q149C3",1065,0,"Leucine-rich repeat and immunoglobulin-like domain containing-NOGO receptor-interacting protein 4","YJL005w_1",60.5,7e-08,"COG4886","pfam00105","zf-C4","Zinc finger, C4 type (two domains). In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.","GO:0051965|positive regulation of synapse assembly;","GO:0005615|extracellular space;GO:0016021|integral component of membrane;GO:0031012|extracellular matrix;",".","K23533","LINGO, LRRN6; leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein"]
["ENSRNOG00000038215",2,0.128660876,8,0.516494877,0.249103877,-2.005180619,0.049345242,0.022925726,"down","yes","AC120448.1","protein_coding","chr4:103294885-103295463:+","gi|672018419|ref|XP_008773990.1|",949,{"v":3e-128,"d":"3.00E-128"},"PREDICTED: zinc finger matrin-type protein 1-like [Rattus norvegicus]","gi|672018418|ref|XM_008775768.1|",579,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102552663 (LOC102552663), mRNA","Q5H9K5",60.8,1e-09,"Zinc finger matrin-type protein 1",".",".",".",".","pfam06632","XRCC4","DNA double-strand break repair and V(D)J recombination protein XRCC4. This family consists of several eukaryotic DNA double-strand break repair and V(D)J recombination protein XRCC4 sequences. In the non-homologous end joining pathway of DNA double-strand break repair, the ligation step is catalysed by a complex of XRCC4 and DNA ligase IV. It is thought that XRCC4 and ligase IV are essential for alignment-based gap filling, as well as for final ligation of the breaks.",".",".",".",".","."]
["ENSRNOG00000042601",2,0.128660876,8,0.516494877,0.249103877,-2.005180619,0.049345242,0.022925726,"down","yes","Zglp1","protein_coding","chr8:19599998-19604547:-","gi|564309626|ref|XP_006226374.1|",1435,0,"PREDICTED: GATA-type zinc finger protein 1 [Rattus norvegicus]","gi|672022571|ref|XM_006226312.2|",955,0,"PREDICTED: Rattus norvegicus zinc finger, GATA-like protein 1 (Zglp1), mRNA","Q1WG82",509,0,"GATA-type zinc finger protein 1","ECU08g1400",52,5e-07,"COG5641","pfam00320","GATA","GATA zinc finger. This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contains a single copy of the domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007283|spermatogenesis;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048599|oocyte development;","GO:0005634|nucleus;","GO:0008270|zinc ion binding;GO:0043565|sequence-specific DNA binding;","K21630","ZGLP1; GATA-type zinc finger protein 1"]
["ENSRNOG00000060334",2,0.128660876,8,0.516494877,0.249103877,-2.005180619,0.049345242,0.022925726,"down","yes","Cdx1","protein_coding","chr18:54473444-54490814:-","gi|524949454|ref|XP_005074745.1|",642,{"v":2E-79,"d":"2.00E-79"},"PREDICTED: homeobox protein CDX-1 [Mesocricetus auratus]","gi|672083922|ref|XM_006254816.2|",695,0,"PREDICTED: Rattus norvegicus caudal type homeo box 1 (Cdx1), transcript variant X2, mRNA","P18111",239,{"v":3e-76,"d":"3.00E-76"},"Homeobox protein CDX-1",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0007389|pattern specification process;GO:0009790|embryo development;GO:0009887|animal organ morphogenesis;GO:0009948|anterior/posterior axis specification;GO:0009952|anterior/posterior pattern specification;GO:0014807|regulation of somitogenesis;GO:0030154|cell differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0060349|bone morphogenesis;","GO:0005634|nucleus;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0008327|methyl-CpG binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09312","CDX1_4; homeobox protein CDX1/4"]
["ENSRNOG00000063814",2,0.128660876,8,0.516494877,0.249103877,-2.005180619,0.049345242,0.022925726,"down","yes","ENSRNOG00000063814","lncRNA","chr14:9055596-9060265:+","gi|537176391|gb|ERE75120.1|",213,{"v":4e-16,"d":"4.00E-16"},"IQ domain-containing protein H [Cricetulus griseus]","gi|49615115|gb|AC118414.9|",184,{"v":7e-89,"d":"7.00E-89"},"Rattus norvegicus 3 BAC CH230-223K21 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam05187","ETF_QO","Electron transfer flavoprotein-ubiquinone oxidoreductase. Electron-transfer flavoprotein-ubiquinone oxidoreductase (ETF-QO) in the inner mitochondrial membrane accepts electrons from electron-transfer flavoprotein which is located in the mitochondrial matrix and reduces ubiquinone in the mitochondrial membrane. The two redox centres in the protein, FAD and a [4Fe4S] cluster, are present in a 64-kDa monomer.",".",".",".",".","."]
["ENSRNOG00000065335",2,0.128660876,8,0.516494877,0.249103877,-2.005180619,0.049345242,0.022925726,"down","yes","ENSRNOG00000065335","protein_coding","chr1:73670420-73673563:+","gi|157823934|ref|NP_001101940.1|",2413,0,"myeloid zinc finger 1 [Rattus norvegicus]","gi|157823933|ref|NM_001108470.1|",2358,0,"Rattus norvegicus myeloid zinc finger 1 (Mzf1), mRNA","P28698",755,0,"Myeloid zinc finger 1",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.",".",".",".",".","."]
["ENSRNOG00000065390",2,0.128660876,8,0.516494877,0.249103877,-2.005180619,0.049345242,0.022925726,"down","yes","Olr1387","protein_coding","chr10:33596756-33601318:+","gi|47576123|ref|NP_001000001.1|",1387,{"v":1E-176,"d":"1.00E-176"},"olfactory receptor Olr1387 [Rattus norvegicus]","gi|20068543|emb|AL606829.13|",1683,0,"Mouse DNA sequence from clone RP23-10M12 on chromosome 11, complete sequence","Q60883",497,{"v":2e-162,"d":"2.00E-162"},"Olfactory receptor 10",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.",".",".",".",".","."]
["ENSRNOG00000065404",2,0.128660876,8,0.516494877,0.249103877,-2.005180619,0.049345242,0.022925726,"down","yes","ENSRNOG00000065404","lncRNA","chr5:131458830-131463898:+",".",".",".",".","gi|354791548|gb|JN956049.1|",150,{"v":2E-70,"d":"2.00E-70"},"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Ipo13:tm1e(EUCOMM)Hmgu; transgenic",".",".",".",".",".",".",".",".","pfam12449","DUF3684","Protein of unknown function (DUF3684). This domain family is found in eukaryotes, and is typically between 1072 and 1090 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000069611",2,0.128660876,8,0.516494877,0.249103877,-2.005180619,0.049345242,0.022925726,"down","yes","ENSRNOG00000069611","lncRNA","chr3:15802470-15822182:-",".",".",".",".","gi|26984852|emb|AL928710.6|",437,0,"Mouse DNA sequence from clone RP23-255P20 on chromosome 2, complete sequence",".",".",".",".",".",".",".",".","pfam12968","DUF3856","Domain of Unknown Function (DUF3856). TPR-like protein. The 2hr2 structure belongs to the SCOP all alpha class, TPR-like superfamily, CT2138-like family. A DALI search gives hits with the putative peptidyl-prolyl isomerase 2fbn (Z=16), the SGTA protein (Z=16), the PLCR protein 2qfc (Z=16), a putative FK506-binding protein (PDB:1qz2-A; DALI Z-score 15.3; RMSD 2.9; 16% sequence identity within 132 superimposed residues), and with the tetratricopeptide repeats of the protein phosphatase 5 (PDB:2bug; DALI Z-score 15.1; RMSD 2.5; 19% sequence identity within 117 superimposed residues).",".",".",".",".","."]
["ENSRNOG00000069881",2,0.128660876,8,0.516494877,0.249103877,-2.005180619,0.049345242,0.022925726,"down","yes","ENSRNOG00000069881","lncRNA","chr12:42848466-42852154:+","gi|343472787|emb|CCD15146.1|",202,{"v":4e-13,"d":"4.00E-13"},"unnamed protein product [Trypanosoma congolense IL3000]","gi|354790908|gb|JN955409.1|",948,0,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Tmem119:tm1a(EUCOMM)Wtsi; transgenic",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["ENSRNOG00000070117",2,0.128660876,8,0.516494877,0.249103877,-2.005180619,0.049345242,0.022925726,"down","yes","ENSRNOG00000070117","lncRNA","chr10:19371500-19404525:+",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","pfam03094","Mlo","Mlo family. A family of plant integral membrane proteins, first discovered in barley. Mutants lacking wild-type Mlo proteins show broad spectrum resistance to the powdery mildew fungus, and dysregulated cell death control, with spontaneous cell death in response to developmental or abiotic stimuli. Thus wild-type Mlo proteins are thought to be inhibitors of cell death whose deficiency lowers the threshold required to trigger the cascade of events that result in plant cell death. Mlo proteins are localized in the plasma membrane and possess seven transmembrane regions; thus the Mlo family is the only major higher plant family to possess 7 transmembrane domains. It has been suggested that Mlo proteins function as G-protein coupled receptors in plants; however the molecular and biological functions of Mlo proteins remain to be fully determined.",".",".",".",".","."]

{"sheet":"CTX_Con_up","index":1,"n_rows":1749,"n_cols":38,"rows_kept":1749}
["Gene","CTX_count","CTX_normalize","Con_count","Con_normalize","FoldChange","Log2FoldChange","pval","padj","Up/Down","Significant","GeneName","Biotype","Position","NR:Seq-id","NR:Score","NR:Evalue","NR:Description","NT:Seq-id","NT:Score","NT:Evalue","NT:Description","Uniprot:UniProtKB-AC","Uniprot:Score","Uniprot:Evalue","Uniprot:Description","COG:gene","COG:Score","COG:Eval","COG:num","Pfam:pfam_ID","Pfam:pfam_Name","Pfam:pfam_Description","GO:biological_process","GO:cellular_component","GO:molecular_function","KEGG:KO","KEGG:Description"]
["ENSRNOG00000015052",111922,7199.991303,9890,638.516792,11.27611896,3.495198698,0,0,"up","yes","Star","protein_coding","chr16:66264807-66271672:-","gi|13928754|ref|NP_113746.1|",1513,0,"steroidogenic acute regulatory protein, mitochondrial precursor [Rattus norvegicus]","gi|1854382|dbj|AB001349.1|",3363,0,"Rattus norvegicus mRNA for steroidogenic acute regulatory protein, complete cds","P97826",587,0,"Steroidogenic acute regulatory protein, mitochondrial",".",".",".",".","pfam01852","START","START domain.","GO:0006082|organic acid metabolic process;GO:0006694|steroid biosynthetic process;GO:0006699|bile acid biosynthetic process;GO:0006703|estrogen biosynthetic process;GO:0007420|brain development;GO:0007584|response to nutrient;GO:0007623|circadian rhythm;GO:0008203|cholesterol metabolic process;GO:0008211|glucocorticoid metabolic process;GO:0008584|male gonad development;GO:0009410|response to xenobiotic stimulus;GO:0009635|response to herbicide;GO:0009636|response to toxic substance;GO:0010033|response to organic substance;GO:0010212|response to ionizing radiation;GO:0010288|response to lead ion;GO:0010628|positive regulation of gene expression;GO:0014070|response to organic cyclic compound;GO:0014823|response to activity;GO:0016101|diterpenoid metabolic process;GO:0017085|response to insecticide;GO:0017143|insecticide metabolic process;GO:0018879|biphenyl metabolic process;GO:0018894|dibenzo-p-dioxin metabolic process;GO:0018958|phenol-containing compound metabolic process;GO:0018963|phthalate metabolic process;GO:0031667|response to nutrient levels;GO:0032367|intracellular cholesterol transport;GO:0032869|cellular response to insulin stimulus;GO:0034698|response to gonadotropin;GO:0035094|response to nicotine;GO:0035457|cellular response to interferon-alpha;GO:0042542|response to hydrogen peroxide;GO:0042747|circadian sleep/wake cycle, REM sleep;GO:0043434|response to peptide hormone;GO:0043524|negative regulation of neuron apoptotic process;GO:0043627|response to estrogen;GO:0044255|cellular lipid metabolic process;GO:0044321|response to leptin;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0045471|response to ethanol;GO:0046677|response to antibiotic;GO:0048168|regulation of neuronal synaptic plasticity;GO:0048545|response to steroid hormone;GO:0050769|positive regulation of neurogenesis;GO:0050810|regulation of steroid biosynthetic process;GO:0051412|response to corticosterone;GO:0060992|response to fungicide;GO:0061370|testosterone biosynthetic process;GO:0070859|positive regulation of bile acid biosynthetic process;GO:0071222|cellular response to lipopolysaccharide;GO:0071236|cellular response to antibiotic;GO:0071248|cellular response to metal ion;GO:0071276|cellular response to cadmium ion;GO:0071312|cellular response to alkaloid;GO:0071320|cellular response to cAMP;GO:0071333|cellular response to glucose stimulus;GO:0071346|cellular response to interferon-gamma;GO:0071371|cellular response to gonadotropin stimulus;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0071373|cellular response to luteinizing hormone stimulus;GO:0071378|cellular response to growth hormone stimulus;GO:0071407|cellular response to organic cyclic compound;GO:0071549|cellular response to dexamethasone stimulus;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0071872|cellular response to epinephrine stimulus;GO:0120009|intermembrane lipid transfer;","GO:0005739|mitochondrion;GO:0005758|mitochondrial intermembrane space;GO:0005829|cytosol;GO:0030061|mitochondrial crista;GO:0043005|neuron projection;GO:0043025|neuronal cell body;","GO:0005515|protein binding;GO:0015485|cholesterol binding;GO:0120020|intermembrane cholesterol transfer activity;","K16931","STAR; steroidogenic acute regulatory protein, mitochondrial"]
["ENSRNOG00000017531",76285,4907.447477,6215,401.2519578,12.23033902,3.612392491,0,0,"up","yes","Akr1c3","protein_coding","chr17:66110963-66127873:+","gi|55824739|gb|AAH86579.1|",1808,0,"Akr1c18 protein, partial [Rattus norvegicus]","gi|55824738|gb|BC086579.1|",1220,0,"Rattus norvegicus aldo-keto reductase family 1, member C18, mRNA (cDNA clone IMAGE:7307445), partial cds","P51652",674,0,"Aldo-keto reductase family 1 member C18","slr0942",214,{"v":1e-64,"d":"1.00E-64"},"COG0656","pfam00248","Aldo_ket_red","Aldo/keto reductase family. This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.","GO:0006693|prostaglandin metabolic process;GO:0006709|progesterone catabolic process;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007565|female pregnancy;GO:0007567|parturition;GO:0007584|response to nutrient;GO:0008202|steroid metabolic process;GO:0008284|positive regulation of cell proliferation;GO:0008584|male gonad development;GO:0009267|cellular response to starvation;GO:0010942|positive regulation of cell death;GO:0016488|farnesol catabolic process;GO:0030216|keratinocyte differentiation;GO:0034614|cellular response to reactive oxygen species;GO:0042448|progesterone metabolic process;GO:0042574|retinal metabolic process;GO:0043170|macromolecule metabolic process;GO:0044597|daunorubicin metabolic process;GO:0044598|doxorubicin metabolic process;GO:0048385|regulation of retinoic acid receptor signaling pathway;GO:0050810|regulation of steroid biosynthetic process;GO:0051897|positive regulation of protein kinase B signaling;GO:0061370|testosterone biosynthetic process;GO:0071276|cellular response to cadmium ion;GO:0071277|cellular response to calcium ion;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0071379|cellular response to prostaglandin stimulus;GO:0071384|cellular response to corticosteroid stimulus;GO:0071394|cellular response to testosterone stimulus;GO:0071395|cellular response to jasmonic acid stimulus;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0071799|cellular response to prostaglandin D stimulus;GO:0097211|cellular response to gonadotropin-releasing hormone;GO:1900053|negative regulation of retinoic acid biosynthetic process;GO:1904322|cellular response to forskolin;GO:1990646|cellular response to prolactin;GO:2000224|regulation of testosterone biosynthetic process;GO:2000353|positive regulation of endothelial cell apoptotic process;GO:2000379|positive regulation of reactive oxygen species metabolic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0001758|retinal dehydrogenase activity;GO:0004032|alditol:NADP+ 1-oxidoreductase activity;GO:0004033|aldo-keto reductase (NADP) activity;GO:0004745|retinol dehydrogenase activity;GO:0016229|steroid dehydrogenase activity;GO:0016655|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0018636|phenanthrene 9,10-monooxygenase activity;GO:0032052|bile acid binding;GO:0035410|dihydrotestosterone 17-beta-dehydrogenase activity;GO:0045550|geranylgeranyl reductase activity;GO:0045703|ketoreductase activity;GO:0047006|17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity;GO:0047020|15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity;GO:0047023|androsterone dehydrogenase activity;GO:0047086|ketosteroid monooxygenase activity;GO:0047787|delta4-3-oxosteroid 5beta-reductase activity;GO:0047834|D-threo-aldose 1-dehydrogenase activity;","K05295","E1.1.1.149; 20alpha-hydroxysteroid dehydrogenase [EC:1.1.1.149]"]
["ENSRNOG00000008074",59643,3836.860325,5430,350.5708979,10.94460592,3.452148103,0,0,"up","yes","Cyp11a1","protein_coding","chr8:58404669-58434338:+","gi|8393224|ref|NP_058982.1|",2621,0,"cholesterol side-chain cleavage enzyme, mitochondrial precursor [Rattus norvegicus]","gi|58177859|gb|BC089100.1|",1631,0,"Rattus norvegicus cytochrome P450, family 11, subfamily a, polypeptide 1, mRNA (cDNA clone MGC:105469 IMAGE:7307104), complete cds","P14137",1014,0,"Cholesterol side-chain cleavage enzyme, mitochondrial","BH0579",100,{"v":1e-21,"d":"1.00E-21"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0006082|organic acid metabolic process;GO:0006694|steroid biosynthetic process;GO:0006700|C21-steroid hormone biosynthetic process;GO:0006704|glucocorticoid biosynthetic process;GO:0007584|response to nutrient;GO:0007617|mating behavior;GO:0008203|cholesterol metabolic process;GO:0008584|male gonad development;GO:0009410|response to xenobiotic stimulus;GO:0009651|response to salt stress;GO:0010033|response to organic substance;GO:0010212|response to ionizing radiation;GO:0010332|response to gamma radiation;GO:0014037|Schwann cell differentiation;GO:0014070|response to organic cyclic compound;GO:0017085|response to insecticide;GO:0018879|biphenyl metabolic process;GO:0018894|dibenzo-p-dioxin metabolic process;GO:0018958|phenol-containing compound metabolic process;GO:0018963|phthalate metabolic process;GO:0021549|cerebellum development;GO:0021766|hippocampus development;GO:0033197|response to vitamin E;GO:0033327|Leydig cell differentiation;GO:0033591|response to L-ascorbic acid;GO:0033595|response to genistein;GO:0034650|cortisol metabolic process;GO:0034698|response to gonadotropin;GO:0042542|response to hydrogen peroxide;GO:0043200|response to amino acid;GO:0043279|response to alkaloid;GO:0043434|response to peptide hormone;GO:0043627|response to estrogen;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0046677|response to antibiotic;GO:0046686|response to cadmium ion;GO:0048545|response to steroid hormone;GO:0051412|response to corticosterone;GO:0051591|response to cAMP;GO:0060014|granulosa cell differentiation;GO:0060135|maternal process involved in female pregnancy;GO:0060992|response to fungicide;GO:0061370|testosterone biosynthetic process;GO:0071222|cellular response to lipopolysaccharide;GO:0071236|cellular response to antibiotic;GO:0071276|cellular response to cadmium ion;GO:0071320|cellular response to cAMP;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071371|cellular response to gonadotropin stimulus;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0071375|cellular response to peptide hormone stimulus;GO:0071560|cellular response to transforming growth factor beta stimulus;","GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0030061|mitochondrial crista;GO:0043204|perikaryon;","GO:0005506|iron ion binding;GO:0008386|cholesterol monooxygenase (side-chain-cleaving) activity;GO:0015485|cholesterol binding;GO:0020037|heme binding;","K00498","CYP11A; cholesterol monooxygenase (side-chain-cleaving) [EC:1.14.15.6]"]
["ENSRNOG00000000981",65019,4182.70076,7568,488.6041539,8.560510031,3.097696754,0,0,"up","yes","Scarb1","protein_coding","chr12:31296156-31362647:+","gi|149063237|gb|EDM13560.1|",2394,0,"scavenger receptor class B, member 1, isoform CRA_b [Rattus norvegicus]","gi|50881994|gb|AY682847.1|",1215,0,"Rattus norvegicus scavenger receptor class B type 2 (Scarb2) mRNA, complete cds","P97943",849,0,"Scavenger receptor class B member 1",".",".",".",".","pfam01130","CD36","CD36 family. The CD36 family is thought to be a novel class of scavenger receptors. There is also evidence suggesting a possible role in signal transduction. CD36 is involved in cell adhesion.","GO:0001935|endothelial cell proliferation;GO:0006694|steroid biosynthetic process;GO:0006702|androgen biosynthetic process;GO:0006707|cholesterol catabolic process;GO:0006869|lipid transport;GO:0006910|phagocytosis, recognition;GO:0010867|positive regulation of triglyceride biosynthetic process;GO:0010886|positive regulation of cholesterol storage;GO:0010899|regulation of phosphatidylcholine catabolic process;GO:0015914|phospholipid transport;GO:0015920|lipopolysaccharide transport;GO:0030301|cholesterol transport;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0032497|detection of lipopolysaccharide;GO:0033344|cholesterol efflux;GO:0034375|high-density lipoprotein particle remodeling;GO:0034381|plasma lipoprotein particle clearance;GO:0034383|low-density lipoprotein particle clearance;GO:0034384|high-density lipoprotein particle clearance;GO:0035461|vitamin transmembrane transport;GO:0042632|cholesterol homeostasis;GO:0043534|blood vessel endothelial cell migration;GO:0043654|recognition of apoptotic cell;GO:0043691|reverse cholesterol transport;GO:0044406|adhesion of symbiont to host;GO:0045056|transcytosis;GO:0050764|regulation of phagocytosis;GO:0050892|intestinal absorption;GO:0051000|positive regulation of nitric-oxide synthase activity;GO:0070328|triglyceride homeostasis;GO:0070508|cholesterol import;","GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005901|caveola;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0031528|microvillus membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0001530|lipopolysaccharide binding;GO:0001540|amyloid-beta binding;GO:0001786|phosphatidylserine binding;GO:0001875|lipopolysaccharide receptor activity;GO:0005044|scavenger receptor activity;GO:0005319|lipid transporter activity;GO:0008035|high-density lipoprotein particle binding;GO:0008289|lipid binding;GO:0030169|low-density lipoprotein particle binding;GO:0034185|apolipoprotein binding;GO:0034186|apolipoprotein A-I binding;GO:0042802|identical protein binding;GO:0070506|high-density lipoprotein particle receptor activity;","K13885","SCARB1; scavenger receptor class B, member 1"]
["ENSRNOG00000070622",68957,4436.034026,12372,798.7593277,5.553655366,2.473437653,0,0,"up","yes","Hsd3b1","protein_coding","chr2:186169863-186175999:-","gi|238336|gb|AAB20228.1|",1765,0,"3 beta-hydroxysteroid dehydrogenase isomerase type II.2 [Rattus sp.]","gi|531215|gb|M38178.1|RAT3BHSDA",1622,0,"Rat 3-beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase type I (3-beta-HSD) mRNA, complete cds","P22071",728,0,"3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1","ML1942",103,{"v":3E-23,"d":"3.00E-23"},"COG0451","pfam01073","3Beta_HSD","3-beta hydroxysteroid dehydrogenase/isomerase family. The enzyme 3 beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase (3 beta-HSD) catalyses the oxidation and isomerization of 5-ene-3 beta-hydroxypregnene and 5-ene-hydroxyandrostene steroid precursors into the corresponding 4-ene-ketosteroids necessary for the formation of all classes of steroid hormones.",".",".",".",".","."]
["ENSRNOG00000029886",48066,3092.106842,5854,377.9451264,8.181364504,3.032341479,0,0,"up","yes","Hba-a2","protein_coding","chr10:15307815-15338392:-","gi|392331680|ref|XP_002724712.2|",1102,{"v":3E-148,"d":"3.00E-148"},"PREDICTED: hemoglobin subunit theta-1-like isoform X1 [Rattus norvegicus]","gi|672067068|ref|XM_002727758.4|",1089,0,"PREDICTED: Rattus norvegicus hemoglobin, theta 1B (Hbq1b), transcript variant X1, mRNA","P09105",201,{"v":1E-61,"d":"1.00E-61"},"Hemoglobin subunit theta-1",".",".",".",".","pfam00042","Globin","Globin.","GO:0001701|in utero embryonic development;GO:0009617|response to bacterium;GO:0015671|oxygen transport;GO:0035634|response to stilbenoid;GO:0042744|hydrogen peroxide catabolic process;GO:0045776|negative regulation of blood pressure;GO:0048821|erythrocyte development;GO:0051930|regulation of sensory perception of pain;GO:0098869|cellular oxidant detoxification;","GO:0005833|hemoglobin complex;GO:0031838|haptoglobin-hemoglobin complex;GO:0045202|synapse;","GO:0001540|amyloid-beta binding;GO:0004601|peroxidase activity;GO:0005344|oxygen carrier activity;GO:0005506|iron ion binding;GO:0005515|protein binding;GO:0019825|oxygen binding;GO:0020037|heme binding;GO:0031720|haptoglobin binding;GO:0043177|organic acid binding;","K13822","HBA; hemoglobin subunit alpha"]
["ENSRNOG00000015020",23896,1537.240151,2787,179.9339029,8.543360236,3.094803616,0,0,"up","yes","Idh1","protein_coding","chr9:66534146-66563708:-","gi|13928690|ref|NP_113698.1|",2117,0,"isocitrate dehydrogenase [NADP] cytoplasmic [Rattus norvegicus]","gi|672065079|ref|XM_006245049.2|",1437,0,"PREDICTED: Rattus norvegicus isocitrate dehydrogenase 1 (NADP+), soluble (Idh1), transcript variant X1, mRNA","P41562",820,0,"Isocitrate dehydrogenase [NADP] cytoplasmic","BMEI0791",560,0,"COG0538","pfam00180","Iso_dh","Isocitrate/isopropylmalate dehydrogenase.","GO:0006097|glyoxylate cycle;GO:0006099|tricarboxylic acid cycle;GO:0006102|isocitrate metabolic process;GO:0006103|2-oxoglutarate metabolic process;GO:0006739|NADP metabolic process;GO:0006749|glutathione metabolic process;GO:0006979|response to oxidative stress;GO:0008585|female gonad development;GO:0014070|response to organic cyclic compound;GO:0048545|response to steroid hormone;GO:0060696|regulation of phospholipid catabolic process;GO:0071071|regulation of phospholipid biosynthetic process;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005777|peroxisome;GO:0005829|cytosol;","GO:0000287|magnesium ion binding;GO:0004448|isocitrate dehydrogenase activity;GO:0004450|isocitrate dehydrogenase (NADP+) activity;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0050661|NADP binding;GO:0051287|NAD binding;","K00031","IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]"]
["ENSRNOG00000046005",32604,2097.429607,8838,570.5977156,3.675846484,1.878076516,0,0,"up","yes","Scd2","protein_coding","chr1:243169236-243182232:+","gi|13929208|ref|NP_114029.1|",1936,0,"acyl-CoA desaturase 2 [Rattus norvegicus]","gi|32362325|gb|AC105487.6|",2743,0,"Rattus norvegicus 1 BAC CH230-229J7 (Children's Hospital Oakland Research Institute) complete sequence","Q6P7B9",749,0,"Acyl-CoA desaturase 2","SPCC1281.06c_1",209,{"v":9e-58,"d":"9.00E-58"},"COG1398","pfam00487","FA_desaturase","Fatty acid desaturase.","GO:0006633|fatty acid biosynthetic process;GO:0006636|unsaturated fatty acid biosynthetic process;GO:0042552|myelination;GO:0070542|response to fatty acid;GO:1903966|monounsaturated fatty acid biosynthetic process;","GO:0005730|nucleolus;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0030176|integral component of endoplasmic reticulum membrane;","GO:0004768|stearoyl-CoA 9-desaturase activity;GO:0005506|iron ion binding;GO:0032896|palmitoyl-CoA 9-desaturase activity;","K00507","SCD, desC; stearoyl-CoA desaturase (Delta-9 desaturase) [EC:1.14.19.1]"]
["ENSRNOG00000053086",40215,2587.048572,13880,896.118612,2.886948822,1.529545533,0,0,"up","yes","Selenop","protein_coding","chr2:52498339-52508852:+","gi|15011857|ref|NP_062065.2|",1601,0,"selenoprotein P precursor [Rattus norvegicus]","gi|206893|gb|M63574.1|RATSELENOP",2372,0,"Rat selenoprotein P mRNA, complete cds","P25236",621,0,"Selenoprotein P",".",".",".",".","pfam04592","SelP_N","Selenoprotein P, N terminal region. SelP is the only known eukaryotic selenoprotein that contains multiple selenocysteine (Sec) residues, and accounts for more than 50% of the selenium content of rat and human plasma. It is thought to be glycosylated. SelP may have antioxidant properties. It can attach to epithelial cells, and may protect vascular endothelial cells against peroxynitrite toxicity. The high selenium content of SelP suggests that it may be involved in selenium intercellular transport or storage. The promoter structure of bovine SelP suggest that it may be involved in countering heavy metal intoxication, and may also have a developmental function. The N-terminal region of SelP can exist independently of the C terminal region. Zebrafish selenoprotein Pb lacks the C terminal Sec-rich region, and a protein encoded by the rat SelP gene and lacking this region has also been reported. N-terminal region contains a conserved SecxxCys motif, which is similar to the CysxxCys found in thioredoxins. It is speculated that the N terminal region may adopt a thioredoxin fold and catalyse redox reactions. The N-terminal region also contains a His-rich region, which is thought to mediate heparin binding. Binding to heparan proteoglycans could account for the membrane binding properties of SelP. The function of the bacterial members of this family is uncharcterised.","GO:0001887|selenium compound metabolic process;GO:0007420|brain development;GO:0007626|locomotory behavior;GO:0009791|post-embryonic development;GO:0010269|response to selenium ion;GO:0019953|sexual reproduction;GO:0040008|regulation of growth;","GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0008430|selenium binding;",".","."]
["ENSRNOG00000012123",17179,1105.132598,2274,146.8136689,7.527450313,2.91216128,0,0,"up","yes","Fdx1","protein_coding","chr8:52268536-52287414:-","gi|149041664|gb|EDL95505.1|",913,{"v":3e-121,"d":"3.00E-121"},"ferredoxin 1 [Rattus norvegicus]","gi|8393354|ref|NM_017126.1|",829,0,"Rattus norvegicus ferredoxin 1 (Fdx1), mRNA","P24483",355,{"v":3E-122,"d":"3.00E-122"},"Adrenodoxin, mitochondrial","RC0261",112,{"v":3e-29,"d":"3.00E-29"},"COG0633","pfam00111","Fer2","2Fe-2S iron-sulfur cluster binding domain.","GO:0006694|steroid biosynthetic process;GO:0008203|cholesterol metabolic process;GO:0022900|electron transport chain;GO:0030325|adrenal gland development;GO:0034698|response to gonadotropin;GO:0042446|hormone biosynthetic process;GO:0044320|cellular response to leptin stimulus;GO:0044321|response to leptin;GO:0050790|regulation of catalytic activity;GO:0051353|positive regulation of oxidoreductase activity;GO:0070995|NADPH oxidation;GO:0071320|cellular response to cAMP;GO:0071407|cellular response to organic cyclic compound;GO:0071872|cellular response to epinephrine stimulus;GO:1904322|cellular response to forskolin;","GO:0005739|mitochondrion;GO:0005759|mitochondrial matrix;GO:0030061|mitochondrial crista;","GO:0005506|iron ion binding;GO:0008386|cholesterol monooxygenase (side-chain-cleaving) activity;GO:0009055|electron transfer activity;GO:0015039|NADPH-adrenodoxin reductase activity;GO:0019899|enzyme binding;GO:0051537|2 iron, 2 sulfur cluster binding;","K22070","FDX1, ADX; ferredoxin-1, mitochondrial"]
["ENSRNOG00000014525",17551,1129.063521,2746,177.2868666,6.368568311,2.670969083,0,0,"up","yes","Hspd1","protein_coding","chr9:56579201-56589662:-","gi|183396771|ref|NP_034607.3|",2854,0,"60 kDa heat shock protein, mitochondrial [Mus musculus]","gi|206597442|ref|NM_022229.2|",2222,0,"Rattus norvegicus heat shock protein family D member 1 (Hspd1), mRNA","P63039",1103,0,"60 kDa heat shock protein, mitochondrial","SPAC12G12.04",615,0,"COG0459","pfam00118","Cpn60_TCP1","TCP-1/cpn60 chaperonin family. This family includes members from the HSP60 chaperone family and the TCP-1 (T-complex protein) family.","GO:0001666|response to hypoxia;GO:0002755|MyD88-dependent toll-like receptor signaling pathway;GO:0002842|positive regulation of T cell mediated immune response to tumor cell;GO:0002931|response to ischemia;GO:0006457|protein folding;GO:0006458|'de novo' protein folding;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006986|response to unfolded protein;GO:0008637|apoptotic mitochondrial changes;GO:0009408|response to heat;GO:0009409|response to cold;GO:0009410|response to xenobiotic stimulus;GO:0010033|response to organic substance;GO:0014070|response to organic cyclic compound;GO:0014823|response to activity;GO:0032496|response to lipopolysaccharide;GO:0032727|positive regulation of interferon-alpha production;GO:0032729|positive regulation of interferon-gamma production;GO:0032733|positive regulation of interleukin-10 production;GO:0032735|positive regulation of interleukin-12 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0033198|response to ATP;GO:0034514|mitochondrial unfolded protein response;GO:0034605|cellular response to heat;GO:0042026|protein refolding;GO:0042100|B cell proliferation;GO:0042110|T cell activation;GO:0042113|B cell activation;GO:0042220|response to cocaine;GO:0042542|response to hydrogen peroxide;GO:0043032|positive regulation of macrophage activation;GO:0043065|positive regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0043524|negative regulation of neuron apoptotic process;GO:0043627|response to estrogen;GO:0045041|protein import into mitochondrial intermembrane space;GO:0048291|isotype switching to IgG isotypes;GO:0050729|positive regulation of inflammatory response;GO:0050821|protein stabilization;GO:0050870|positive regulation of T cell activation;GO:0051384|response to glucocorticoid;GO:0051702|interaction with symbiont;GO:0071866|negative regulation of apoptotic process in bone marrow;GO:0098761|cellular response to interleukin-7;GO:1903427|negative regulation of reactive oxygen species biosynthetic process;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0005759|mitochondrial matrix;GO:0005769|early endosome;GO:0005782|peroxisomal matrix;GO:0005791|rough endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005905|clathrin-coated pit;GO:0009986|cell surface;GO:0016020|membrane;GO:0030061|mitochondrial crista;GO:0030135|coated vesicle;GO:0030141|secretory granule;GO:0031985|Golgi cisterna;GO:0032991|protein-containing complex;GO:0042588|zymogen granule;GO:0043231|intracellular membrane-bounded organelle;GO:0045121|membrane raft;GO:0046696|lipopolysaccharide receptor complex;GO:0070062|extracellular exosome;GO:0097225|sperm midpiece;","GO:0001530|lipopolysaccharide binding;GO:0002039|p53 binding;GO:0003725|double-stranded RNA binding;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0008035|high-density lipoprotein particle binding;GO:0016853|isomerase activity;GO:0019899|enzyme binding;GO:0031625|ubiquitin protein ligase binding;GO:0034185|apolipoprotein binding;GO:0034186|apolipoprotein A-I binding;GO:0044877|protein-containing complex binding;GO:0051087|chaperone binding;GO:0140030|modification-dependent protein binding;","K04077","groEL, HSPD1; chaperonin GroEL"]
["ENSRNOG00000051624",16035,1031.538576,2372,153.1407311,6.735886455,2.751867819,0,0,"up","yes","Hspe1","protein_coding","chr9:56589789-56593089:+","gi|674078133|ref|XP_008846520.1|",499,{"v":3e-59,"d":"3.00E-59"},"PREDICTED: 10 kDa heat shock protein, mitochondrial isoform X2 [Nannospalax galili]","gi|298894148|emb|FQ220992.1|",545,0,"Rattus norvegicus TL0ADA40YO12 mRNA sequence","P26772",180,{"v":4E-55,"d":"4.00E-55"},"10 kDa heat shock protein, mitochondrial","SPCC550.06c",75.1,{"v":3e-16,"d":"3.00E-16"},"COG0234","pfam00166","Cpn10","Chaperonin 10 Kd subunit. This family contains GroES and Gp31-like chaperonins. Gp31 is a functional co-chaperonin that is required for the folding and assembly of Gp23, a major capsid protein, during phage morphogenesis.","GO:0006457|protein folding;GO:0051085|chaperone cofactor-dependent protein refolding;","GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0005759|mitochondrial matrix;GO:0005782|peroxisomal matrix;","GO:0005524|ATP binding;GO:0046872|metal ion binding;GO:0051082|unfolded protein binding;GO:0051087|chaperone binding;","K04078","groES, HSPE1; chaperonin GroES"]
["ENSRNOG00000013484",19877,1278.69612,4129,266.5759185,4.796742808,2.262055087,0,0,"up","yes","Gsta1","protein_coding","chr9:23703477-23720121:-","gi|13928688|ref|NP_113697.1|",967,{"v":4e-127,"d":"4.00E-127"},"glutathione S-transferase alpha-3 [Rattus norvegicus]","gi|58331131|ref|NM_031509.2|",783,0,"Rattus norvegicus glutathione S-transferase alpha 1 (Gsta1), mRNA","P04904",377,{"v":1e-128,"d":"1.00E-128"},"Glutathione S-transferase alpha-3",".",".",".",".","pfam02798","GST_N","Glutathione S-transferase, N-terminal domain. Function: conjugation of reduced glutathione to a variety of targets. Also included in the alignment, but are not GSTs: * S-crystallins from squid. Similarity to GST previously noted. * Eukaryotic elongation factors 1-gamma. Not known to have GST activity; similarity not previously recognized. * HSP26 family of stress-related proteins. including auxin-regulated proteins in plants and stringent starvation proteins in Escherichia coli. Not known to have GST activity. Similarity not previously recognized. The glutathione molecule binds in a cleft between N and C-terminal domains - the catalytically important residues are proposed to reside in the N-terminal domain.","GO:0006693|prostaglandin metabolic process;GO:0006749|glutathione metabolic process;GO:0006805|xenobiotic metabolic process;GO:0007568|aging;GO:0009410|response to xenobiotic stimulus;GO:0030855|epithelial cell differentiation;GO:0031667|response to nutrient levels;GO:0042178|xenobiotic catabolic process;GO:0043651|linoleic acid metabolic process;GO:0098869|cellular oxidant detoxification;GO:1901687|glutathione derivative biosynthetic process;","GO:0005829|cytosol;GO:0031090|organelle membrane;","GO:0004364|glutathione transferase activity;GO:0004602|glutathione peroxidase activity;GO:0004769|steroid delta-isomerase activity;GO:0005504|fatty acid binding;GO:0035731|dinitrosyl-iron complex binding;GO:0043295|glutathione binding;","K00799","GST, gst; glutathione S-transferase [EC:2.5.1.18]"]
["ENSRNOG00000001242",15200,977.8226604,2077,134.0949825,7.292015273,2.866317583,0,0,"up","yes","Gstt3","protein_coding","chr20:12874854-12882599:+","gi|21536248|ref|NP_598755.1|",1235,{"v":2e-163,"d":"2.00E-163"},"glutathione S-transferase, theta 3 [Mus musculus]","gi|298910612|emb|FQ225600.1|",1663,0,"Rattus norvegicus TL0AEA4YH19 mRNA sequence","Q99L20",480,{"v":5e-165,"d":"5.00E-165"},"Glutathione S-transferase theta-3",".",".",".",".","pfam02798","GST_N","Glutathione S-transferase, N-terminal domain. Function: conjugation of reduced glutathione to a variety of targets. Also included in the alignment, but are not GSTs: * S-crystallins from squid. Similarity to GST previously noted. * Eukaryotic elongation factors 1-gamma. Not known to have GST activity; similarity not previously recognized. * HSP26 family of stress-related proteins. including auxin-regulated proteins in plants and stringent starvation proteins in Escherichia coli. Not known to have GST activity. Similarity not previously recognized. The glutathione molecule binds in a cleft between N and C-terminal domains - the catalytically important residues are proposed to reside in the N-terminal domain.","GO:0006749|glutathione metabolic process;","GO:0005737|cytoplasm;","GO:0004364|glutathione transferase activity;","K00799","GST, gst; glutathione S-transferase [EC:2.5.1.18]"]
["ENSRNOG00000063905",13529,870.3264982,1692,109.2386665,7.967201777,2.994073113,0,0,"up","yes","Hsd3b3","protein_coding","chr2:186138044-186144033:-","gi|238336|gb|AAB20228.1|",1861,0,"3 beta-hydroxysteroid dehydrogenase isomerase type II.2 [Rattus sp.]","gi|110835752|ref|NM_001042619.1|",1611,0,"Rattus norvegicus hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 (Hsd3b3), mRNA","P22072",726,0,"3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2","ML1942",105,{"v":7e-24,"d":"7.00E-24"},"COG0451","pfam01073","3Beta_HSD","3-beta hydroxysteroid dehydrogenase/isomerase family. The enzyme 3 beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase (3 beta-HSD) catalyses the oxidation and isomerization of 5-ene-3 beta-hydroxypregnene and 5-ene-hydroxyandrostene steroid precursors into the corresponding 4-ene-ketosteroids necessary for the formation of all classes of steroid hormones.",".",".",".",".","."]
["ENSRNOG00000056596",14424,927.9022404,2293,148.0403442,6.267901128,2.647982422,0,0,"up","yes","Alas1","protein_coding","chr8:106876514-106889917:-","gi|42475958|ref|NP_077810.2|",2935,0,"5-aminolevulinate synthase, nonspecific, mitochondrial precursor [Rattus norvegicus]","gi|42475957|ref|NM_024484.2|",1834,0,"Rattus norvegicus 5'-aminolevulinate synthase 1 (Alas1), mRNA","P13195",1135,0,"5-aminolevulinate synthase, nonspecific, mitochondrial","AGc4738",389,{"v":3E-122,"d":"3.00E-122"},"COG0156","pfam00155","Aminotran_1_2","Aminotransferase class I and II.","GO:0001666|response to hypoxia;GO:0006782|protoporphyrinogen IX biosynthetic process;GO:0006783|heme biosynthetic process;GO:0009410|response to xenobiotic stimulus;GO:0009635|response to herbicide;GO:0010033|response to organic substance;GO:0010045|response to nickel cation;GO:0014070|response to organic cyclic compound;GO:0031667|response to nutrient levels;GO:0032025|response to cobalt ion;GO:0032869|cellular response to insulin stimulus;GO:0034698|response to gonadotropin;GO:0042541|hemoglobin biosynthetic process;GO:0045471|response to ethanol;GO:0048821|erythrocyte development;GO:0051591|response to cAMP;GO:0070541|response to platinum ion;GO:0071407|cellular response to organic cyclic compound;","GO:0005654|nucleoplasm;GO:0005739|mitochondrion;GO:0005759|mitochondrial matrix;GO:0005829|cytosol;","GO:0003870|5-aminolevulinate synthase activity;GO:0030170|pyridoxal phosphate binding;GO:0042802|identical protein binding;","K00643","E2.3.1.37, ALAS; 5-aminolevulinate synthase [EC:2.3.1.37]"]
["ENSRNOG00000069830",14560,936.65118,2548,164.5036184,5.693802903,2.509392553,0,0,"up","yes","ENSRNOG00000069830","protein_coding","chr3:74282149-74287593:-","gi|852749799|ref|XP_012872059.1|",1849,0,"PREDICTED: endogenous retrovirus group K member 8 Pol protein-like [Dipodomys ordii]","gi|46240867|gb|AC107531.8|",5002,0,"Rattus norvegicus 1 BAC CH230-158N3 (Children's Hospital Oakland Research Institute) complete sequence","P04026",563,0,"Intracisternal A-particle Pol-related polyprotein (Fragment)","YIL082w-a_2",80.5,{"v":4E-14,"d":"4.00E-14"},"COG2801","pfam00078","RVT_1","Reverse transcriptase (RNA-dependent DNA polymerase). A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs, hepadnaviruses, and caulimoviruses.",".",".",".",".","."]
["ENSRNOG00000014453",18311,1177.954654,4919,317.5797876,3.709161286,1.891093002,0,0,"up","yes","Anxa5","protein_coding","chr2:119314007-119353369:-","gi|564336221|ref|XP_006232330.1|",1643,0,"PREDICTED: annexin A5 isoform X1 [Rattus norvegicus]","gi|672042039|ref|XM_006232268.2|",1524,0,"PREDICTED: Rattus norvegicus annexin A5 (Anxa5), transcript variant X1, mRNA","P14668",635,0,"Annexin A5",".",".",".",".","pfam00191","Annexin","Annexin. This family of annexins also includes giardin that has been shown to function as an annexin.","GO:0007596|blood coagulation;GO:0010033|response to organic substance;GO:0030195|negative regulation of blood coagulation;GO:0043065|positive regulation of apoptotic process;GO:0050819|negative regulation of coagulation;GO:0051592|response to calcium ion;GO:0070588|calcium ion transmembrane transport;GO:0071284|cellular response to lead ion;GO:0097066|response to thyroid hormone;GO:0097211|cellular response to gonadotropin-releasing hormone;GO:1901317|regulation of flagellated sperm motility;GO:1902721|negative regulation of prolactin secretion;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0008021|synaptic vesicle;GO:0009897|external side of plasma membrane;GO:0014704|intercalated disc;GO:0030018|Z disc;GO:0030425|dendrite;GO:0042383|sarcolemma;GO:0042995|cell projection;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0043679|axon terminus;GO:0072563|endothelial microparticle;","GO:0005388|calcium-transporting ATPase activity;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0005544|calcium-dependent phospholipid binding;GO:0017046|peptide hormone binding;GO:0030971|receptor tyrosine kinase binding;GO:0042802|identical protein binding;","K16646","ANXA5; annexin A5"]
["ENSRNOG00000025764",9934,639.0585729,1262,81.47706688,7.843416526,2.971482217,0,0,"up","yes","AC128848.1","protein_coding","chr19:10826032-10827049:-","gi|528756970|gb|EPY76629.1|",115,1e-05,"hypothetical protein CB1_001402132 [Camelus ferus]","gi|298916670|emb|FQ210386.1|",390,0,"Rattus norvegicus TL0ABA29YM22 mRNA sequence",".",".",".",".",".",".",".",".","pfam00131","Metallothio","Metallothionein.",".",".",".",".","."]
["ENSRNOG00000019120",17932,1153.573418,5360,346.0515678,3.33353039,1.737050879,0,0,"up","yes","Hmgcs2","protein_coding","chr2:185875616-185902130:+","gi|148707009|gb|EDL38956.1|",2789,0,"3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2, isoform CRA_b, partial [Mus musculus]","gi|672043353|ref|XM_006233002.2|",1980,0,"PREDICTED: Rattus norvegicus 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) (Hmgcs2), transcript variant X1, mRNA","P22791",1059,0,"Hydroxymethylglutaryl-CoA synthase, mitochondrial","SPAC4F8.14c",448,{"v":4E-150,"d":"4.00E-150"},"COG3425","pfam08540","HMG_CoA_synt_C","Hydroxymethylglutaryl-coenzyme A synthase C terminal.","GO:0001822|kidney development;GO:0001889|liver development;GO:0006084|acetyl-CoA metabolic process;GO:0006695|cholesterol biosynthetic process;GO:0007420|brain development;GO:0007494|midgut development;GO:0007584|response to nutrient;GO:0009266|response to temperature stimulus;GO:0009410|response to xenobiotic stimulus;GO:0009617|response to bacterium;GO:0010038|response to metal ion;GO:0010142|farnesyl diphosphate biosynthetic process, mevalonate pathway;GO:0014070|response to organic cyclic compound;GO:0030324|lung development;GO:0032868|response to insulin;GO:0032869|cellular response to insulin stimulus;GO:0032870|cellular response to hormone stimulus;GO:0033555|multicellular organismal response to stress;GO:0033574|response to testosterone;GO:0033762|response to glucagon;GO:0034014|response to triglyceride;GO:0034284|response to monosaccharide;GO:0034696|response to prostaglandin F;GO:0042594|response to starvation;GO:0043434|response to peptide hormone;GO:0045471|response to ethanol;GO:0046951|ketone body biosynthetic process;GO:0051384|response to glucocorticoid;GO:0051591|response to cAMP;GO:0060416|response to growth hormone;GO:0060612|adipose tissue development;GO:0070542|response to fatty acid;GO:0070543|response to linoleic acid;GO:0071222|cellular response to lipopolysaccharide;GO:0071230|cellular response to amino acid stimulus;GO:0071385|cellular response to glucocorticoid stimulus;GO:0071398|cellular response to fatty acid;GO:0071407|cellular response to organic cyclic compound;","GO:0005739|mitochondrion;GO:0005759|mitochondrial matrix;","GO:0004421|hydroxymethylglutaryl-CoA synthase activity;GO:0042802|identical protein binding;","K01641","HMGCS; hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10]"]
["ENSRNOG00000005615",15069,969.395373,4048,261.3464079,3.709235496,1.891121866,0,0,"up","yes","Gadd45a","protein_coding","chr4:96154789-96157115:-","gi|61889085|ref|NP_077041.2|",656,{"v":2E-78,"d":"2.00E-78"},"growth arrest and DNA damage-inducible protein GADD45 alpha [Rattus norvegicus]","gi|1161227|gb|L39010.1|RATGADD45B",1383,0,"Rattus norvegicus GADD45beta protein (GADD45) gene, complete cds","P48317",254,{"v":6E-79,"d":"6.00E-79"},"Growth arrest and DNA damage-inducible protein GADD45 alpha",".",".",".",".","pfam01248","Ribosomal_L7Ae","Ribosomal protein L7Ae/L30e/S12e/Gadd45 family. This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118.","GO:0000086|G2/M transition of mitotic cell cycle;GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006469|negative regulation of protein kinase activity;GO:0006974|cellular response to DNA damage stimulus;GO:0007098|centrosome cycle;GO:0016525|negative regulation of angiogenesis;GO:0033140|negative regulation of peptidyl-serine phosphorylation of STAT protein;GO:0042770|signal transduction in response to DNA damage;GO:0043065|positive regulation of apoptotic process;GO:0043537|negative regulation of blood vessel endothelial cell migration;GO:0046330|positive regulation of JNK cascade;GO:0051726|regulation of cell cycle;GO:0071260|cellular response to mechanical stimulus;GO:0071479|cellular response to ionizing radiation;GO:0071901|negative regulation of protein serine/threonine kinase activity;GO:1900745|positive regulation of p38MAPK cascade;GO:2000379|positive regulation of reactive oxygen species metabolic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0016607|nuclear speck;","GO:0019900|kinase binding;GO:0042803|protein homodimerization activity;GO:0046982|protein heterodimerization activity;GO:0047485|protein N-terminus binding;GO:1990841|promoter-specific chromatin binding;","K04402","GADD45; growth arrest and DNA-damage-inducible protein"]
["ENSRNOG00000058497",11766,756.9119357,2425,156.5625097,4.834566955,2.27338667,0,0,"up","yes","Fdxr","protein_coding","chr10:100507865-100516658:-","gi|13162347|ref|NP_077067.1|",2411,0,"NADPH:adrenodoxin oxidoreductase, mitochondrial precursor [Rattus norvegicus]","gi|57033193|gb|BC088844.1|",1793,0,"Rattus norvegicus ferredoxin reductase, mRNA (cDNA clone MGC:105420 IMAGE:7308634), complete cds","P56522",933,0,"NADPH:adrenodoxin oxidoreductase, mitochondrial","DR0496",317,{"v":3e-99,"d":"3.00E-99"},"COG0493","pfam13738","Pyr_redox_3","Pyridine nucleotide-disulphide oxidoreductase.","GO:0006744|ubiquinone biosynthetic process;GO:0008203|cholesterol metabolic process;GO:0070995|NADPH oxidation;","GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;","GO:0005515|protein binding;GO:0015039|NADPH-adrenodoxin reductase activity;GO:0016491|oxidoreductase activity;GO:0070402|NADPH binding;","K18914","FDXR; adrenodoxin-NADP+ reductase [EC:1.18.1.6]"]
["ENSRNOG00000018630",26797,1723.862752,11128,718.4443742,2.399438027,1.262696552,0,0,"up","yes","Gapdh","protein_coding","chr4:157962343-157966235:-","gi|8393418|ref|NP_058704.1|",1734,0,"glyceraldehyde-3-phosphate dehydrogenase [Rattus norvegicus]","gi|402691727|ref|NM_017008.4|",1179,0,"Rattus norvegicus glyceraldehyde-3-phosphate dehydrogenase (Gapdh), mRNA","P04797",672,0,"Glyceraldehyde-3-phosphate dehydrogenase","SPBC354.12",499,{"v":8E-167,"d":"8.00E-167"},"COG0057","pfam02800","Gp_dh_C","Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain. GAPDH is a tetrameric NAD-binding enzyme involved in glycolysis and glyconeogenesis. C-terminal domain is a mixed alpha/antiparallel beta fold.","GO:0000226|microtubule cytoskeleton organization;GO:0001819|positive regulation of cytokine production;GO:0005975|carbohydrate metabolic process;GO:0006094|gluconeogenesis;GO:0006096|glycolytic process;GO:0006915|apoptotic process;GO:0007565|female pregnancy;GO:0010951|negative regulation of endopeptidase activity;GO:0017148|negative regulation of translation;GO:0019933|cAMP-mediated signaling;GO:0031640|killing of cells of other organism;GO:0032481|positive regulation of type I interferon production;GO:0035606|peptidyl-cysteine S-trans-nitrosylation;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0050821|protein stabilization;GO:0050832|defense response to fungus;GO:0051402|neuron apoptotic process;GO:0051873|killing by host of symbiont cells;GO:0060359|response to ammonium ion;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0071346|cellular response to interferon-gamma;GO:1905460|negative regulation of vascular associated smooth muscle cell apoptotic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005811|lipid droplet;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0015630|microtubule cytoskeleton;GO:0031965|nuclear membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0097452|GAIT complex;GO:0098978|glutamatergic synapse;GO:0099092|postsynaptic density, intracellular component;GO:1990904|ribonucleoprotein complex;","GO:0004365|glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity;GO:0005515|protein binding;GO:0008017|microtubule binding;GO:0019828|aspartic-type endopeptidase inhibitor activity;GO:0019899|enzyme binding;GO:0035605|peptidyl-cysteine S-nitrosylase activity;GO:0042802|identical protein binding;GO:0050661|NADP binding;GO:0051287|NAD binding;GO:0097718|disordered domain specific binding;","K00134","GAPDH, gapA; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]"]
["ENSRNOG00000071023",11016,708.664107,2127,137.3230755,5.160560995,2.367527907,0,0,"up","yes","Zfp347","protein_coding","chr7:7459701-7484430:+","gi|149034382|gb|EDL89119.1|",3574,0,"rCG29513 [Rattus norvegicus]","gi|19173743|ref|NM_133390.1|",2340,0,"Rattus norvegicus zinc finger protein 347 (Zfp347), mRNA","Q5TYW1",595,{"v":3e-180,"d":"3.00E-180"},"Zinc finger protein 658",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000013766",8583,552.1481509,1092,70.50155074,7.831716397,2.969328523,0,0,"up","yes","Acaa2","protein_coding","chr18:68345012-68373249:+","gi|149027156|gb|EDL82880.1|",2036,0,"acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase), isoform CRA_f [Rattus norvegicus]","gi|18426865|ref|NM_130433.1|",1593,0,"Rattus norvegicus acetyl-CoA acyltransferase 2 (Acaa2), mRNA","P13437",786,0,"3-ketoacyl-CoA thiolase, mitochondrial","BH1997",383,{"v":1e-126,"d":"1.00E-126"},"COG0183","pfam00108","Thiolase_N","Thiolase, N-terminal domain. Thiolase is reported to be structurally related to beta-ketoacyl synthase (pfam00109), and also chalcone synthase.","GO:0006084|acetyl-CoA metabolic process;GO:0006635|fatty acid beta-oxidation;GO:0071456|cellular response to hypoxia;GO:1901029|negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;GO:1902109|negative regulation of mitochondrial membrane permeability involved in apoptotic process;","GO:0005739|mitochondrion;GO:0005759|mitochondrial matrix;","GO:0003985|acetyl-CoA C-acetyltransferase activity;GO:0003986|acetyl-CoA hydrolase activity;GO:0003988|acetyl-CoA C-acyltransferase activity;GO:0016290|palmitoyl-CoA hydrolase activity;GO:0016747|transferase activity, transferring acyl groups other than amino-acyl groups;GO:0047617|acyl-CoA hydrolase activity;GO:0102991|myristoyl-CoA hydrolase activity;","K07508","ACAA2; acetyl-CoA acyltransferase 2 [EC:2.3.1.16]"]
["ENSRNOG00000050445",8531,548.8029682,1208,77.99072646,7.036772102,2.81491379,0,0,"up","yes","Gde1","protein_coding","chr1:172954394-173032429:-","gi|47575864|ref|NP_116004.2|",1316,{"v":2e-177,"d":"2.00E-177"},"glycerophosphodiester phosphodiesterase 1 [Rattus norvegicus]","gi|47575863|ref|NM_032615.2|",597,0,"Rattus norvegicus glycerophosphodiester phosphodiesterase 1 (Gde1), mRNA","Q9JL55",511,{"v":8e-179,"d":"8.00E-179"},"Glycerophosphodiester phosphodiesterase 1","FN1891",71.2,{"v":2e-15,"d":"2.00E-15"},"COG0584","pfam03009","GDPD","Glycerophosphoryl diester phosphodiesterase family. Escherichia coli has two sequence related isozymes of glycerophosphoryl diester phosphodiesterase (GDPD) - periplasmic and cytosolic. This family also includes agrocinopine synthase, the similarity to GDPD has been noted. This family appears to have weak but not significant matches to mammalian phospholipase C pfam00388, which suggests that this family may adopt a TIM barrel fold.","GO:0006580|ethanolamine metabolic process;GO:0006644|phospholipid metabolic process;GO:0007186|G protein-coupled receptor signaling pathway;GO:0070291|N-acylethanolamine metabolic process;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030659|cytoplasmic vesicle membrane;","GO:0004622|lysophospholipase activity;GO:0008081|phosphoric diester hydrolase activity;GO:0008889|glycerophosphodiester phosphodiesterase activity;GO:0046872|metal ion binding;GO:0047395|glycerophosphoinositol glycerophosphodiesterase activity;","K19179","GDE1; glycerophosphoinositol glycerophosphodiesterase [EC:3.1.4.44]"]
["ENSRNOG00000013279",5601,360.3147843,153,9.877964527,36.47662262,5.188900251,0,0,"up","yes","ENSRNOG00000013279","protein_coding","chr1:243078774-243114229:+","gi|672014957|ref|XP_008773072.1|",1789,0,"PREDICTED: acyl-CoA desaturase 1-like [Rattus norvegicus]","gi|672014956|ref|XM_008774850.1|",1268,0,"PREDICTED: Rattus norvegicus similar to stearoyl-coenzyme A desaturase 3 (LOC681458), mRNA","Q99PL7",661,0,"Acyl-CoA desaturase 3","SPCC1281.06c_1",205,{"v":4e-57,"d":"4.00E-57"},"COG1398","pfam00487","FA_desaturase","Fatty acid desaturase.","GO:0006636|unsaturated fatty acid biosynthetic process;GO:0070542|response to fatty acid;GO:1903966|monounsaturated fatty acid biosynthetic process;","GO:0005789|endoplasmic reticulum membrane;GO:0030176|integral component of endoplasmic reticulum membrane;","GO:0004768|stearoyl-CoA 9-desaturase activity;GO:0005506|iron ion binding;GO:0032896|palmitoyl-CoA 9-desaturase activity;","K00507","SCD, desC; stearoyl-CoA desaturase (Delta-9 desaturase) [EC:1.14.19.1]"]
["ENSRNOG00000003291",12254,788.3051895,3102,200.2708887,3.936194595,1.976801546,0,0,"up","yes","Creg1","protein_coding","chr13:78019843-78032308:+","gi|672074362|ref|XP_008767847.1|",793,{"v":1e-96,"d":"1.00E-96"},"PREDICTED: protein CREG1 isoform X1 [Rattus norvegicus]","gi|183986026|gb|BC166446.1|",2103,0,"Rattus norvegicus cellular repressor of E1A-stimulated genes 1, mRNA (cDNA clone MGC:187595 IMAGE:8364240), complete cds","O88668",275,{"v":1e-85,"d":"1.00E-85"},"Protein CREG1",".",".",".",".","pfam13883","Pyrid_oxidase_2","Pyridoxamine 5'-phosphate oxidase.","GO:0006355|regulation of transcription, DNA-templated;","GO:0005615|extracellular space;GO:0005667|transcription factor complex;",".","K25476","CREG; protein CREG"]
["ENSRNOG00000021201",23816,1532.093716,10011,646.328777,2.370455673,1.245164415,0,0,"up","yes","Txnip","protein_coding","chr2:184092991-184096886:+","gi|56912221|ref|NP_001008767.1|",1869,0,"thioredoxin-interacting protein [Rattus norvegicus]","gi|1216375|gb|U30789.1|RNU30789",1743,0,"Rattus norvegicus clone N27 mRNA","Q5M7W1",724,0,"Thioredoxin-interacting protein",".",".",".",".","pfam00339","Arrestin_N","Arrestin (or S-antigen), N-terminal domain. Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006606|protein import into nucleus;GO:0006979|response to oxidative stress;GO:0009410|response to xenobiotic stimulus;GO:0009612|response to mechanical stimulus;GO:0009749|response to glucose;GO:0015031|protein transport;GO:0030216|keratinocyte differentiation;GO:0032355|response to estradiol;GO:0032570|response to progesterone;GO:0042127|regulation of cell proliferation;GO:0042542|response to hydrogen peroxide;GO:0043065|positive regulation of apoptotic process;GO:0043086|negative regulation of catalytic activity;GO:0048008|platelet-derived growth factor receptor signaling pathway;GO:0051592|response to calcium ion;GO:0051782|negative regulation of cell division;GO:0071228|cellular response to tumor cell;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005758|mitochondrial intermembrane space;","GO:0003674|molecular_function;GO:0004857|enzyme inhibitor activity;GO:0031625|ubiquitin protein ligase binding;","K20910","TXNIP; thioredoxin-interacting protein"]
["ENSRNOG00000043098",6383,410.6211869,547,35.31533723,11.62727639,3.53944129,0,0,"up","yes","Mt2A","protein_coding","chr19:10832002-10832784:-","gi|30387810|gb|AAP32010.1|",150,{"v":8e-11,"d":"8.00E-11"},"HLC [Rattus sp.]","gi|298881832|emb|FQ210821.1|",391,0,"Rattus norvegicus TL0ABA21YI18 mRNA sequence",".",".",".",".",".",".",".",".","pfam00131","Metallothio","Metallothionein.","GO:0006882|cellular zinc ion homeostasis;GO:0007263|nitric oxide mediated signal transduction;GO:0009617|response to bacterium;GO:0010273|detoxification of copper ion;GO:0036016|cellular response to interleukin-3;GO:0036018|cellular response to erythropoietin;GO:0045926|negative regulation of growth;GO:0048143|astrocyte activation;GO:0071294|cellular response to zinc ion;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0008270|zinc ion binding;GO:0046870|cadmium ion binding;","K14739","MT1_2; metallothionein 1/2"]
["ENSRNOG00000000036",11234,722.6881426,2723,175.8019438,4.1108086,2.039422201,0,0,"up","yes","Klhdc8a","protein_coding","chr13:43736192-43744277:+","gi|148707735|gb|EDL39682.1|",2057,0,"kelch domain containing 8A, isoform CRA_b, partial [Mus musculus]","gi|281371338|ref|NM_001100683.1|",3199,0,"Rattus norvegicus kelch domain containing 8A (Klhdc8a), mRNA","Q91XA8",725,0,"Kelch domain-containing protein 8A",".",".",".",".","pfam01344","Kelch_1","Kelch motif. The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that the Drosophila ring canal kelch protein is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.",".",".",".",".","."]
["ENSRNOG00000061544",8272,532.1413847,1354,87.41675797,6.087407003,2.605827827,0,0,"up","yes","Spock2","protein_coding","chr20:28033475-28064272:+","gi|564397863|ref|XP_006256481.1|",1786,0,"PREDICTED: testican-2 isoform X1 [Rattus norvegicus]","gi|672086240|ref|XM_006256419.2|",3560,0,"PREDICTED: Rattus norvegicus sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 (Spock2), transcript variant X1, mRNA","Q9ER58",686,0,"Testican-2",".",".",".",".","pfam10591","SPARC_Ca_bdg","Secreted protein acidic and rich in cysteine Ca binding region. The SPARC_Ca_bdg domain of Secreted Protein Acidic and Rich in Cysteine is responsible for the anti-spreading activity of human urothelial cells. It is rich in alpha-helices. This extracellular calcium-binding domain contains two EF-hands that each coordinates one Ca2+ ion, forming a helix-loop-helix structure that not only drives the conformation of the protein but is also necessary for biological activity. The anti-spreading activity was dependent on the coordination of Ca2+ by a Glu residue at the Z position of EF-hand 2.","GO:0010811|positive regulation of cell-substrate adhesion;GO:0019800|peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan;GO:0030198|extracellular matrix organization;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0005576|extracellular region;","GO:0005509|calcium ion binding;GO:0005539|glycosaminoglycan binding;GO:0050840|extracellular matrix binding;","K08136","SPOCK; testican"]
["ENSRNOG00000010306",9963,640.9241556,2537,163.7934379,3.913002643,1.968276085,0,0,"up","yes","H2az1","protein_coding","chr2:226355708-226358485:+","gi|946732930|ref|XP_014398677.1|",544,{"v":9e-64,"d":"9.00E-64"},"PREDICTED: histone H2A.Z, partial [Myotis brandtii]","gi|298903825|emb|FQ213837.1|",791,0,"Rattus norvegicus TL0AAA45YF14 mRNA sequence","Q6YNC8",204,{"v":9e-62,"d":"9.00E-62"},"Histone H2A.Z","SPBC11B10.10c",155,{"v":2e-43,"d":"2.00E-43"},"COG5262","pfam00125","Histone","Core histone H2A/H2B/H3/H4.","GO:0032869|cellular response to insulin stimulus;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0071392|cellular response to estradiol stimulus;","GO:0000786|nucleosome;GO:0000791|euchromatin;GO:0000792|heterochromatin;GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000979|RNA polymerase II core promoter sequence-specific DNA binding;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0031490|chromatin DNA binding;GO:0031492|nucleosomal DNA binding;GO:0046982|protein heterodimerization activity;","K11251","H2A; histone H2A"]
["ENSRNOG00000005371",5140,330.6584523,404,26.0829913,12.6771676,3.664160542,0,0,"up","yes","Klhl29","protein_coding","chr6:28086489-28390647:-","gi|28972876|dbj|BAC65854.1|",4441,0,"mKIAA1921 protein [Mus musculus]","gi|256818757|ref|NM_001106713.2|",6980,0,"Rattus norvegicus kelch-like family member 29 (Klhl29), mRNA","Q80T74",1571,0,"Kelch-like protein 29",".",".",".",".","pfam07707","BACK","BTB And C-terminal Kelch. This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).",".",".",".","K10465","KLHL29, KBTBD9; kelch-like protein 29"]
["ENSRNOG00000005998",15069,969.395373,5494,354.7028569,2.732978757,1.450474246,0,0,"up","yes","Smoc1","protein_coding","chr6:100701346-100862699:+","gi|148670754|gb|EDL02701.1|",2355,0,"SPARC related modular calcium binding 1, isoform CRA_c, partial [Mus musculus]","gi|672056564|ref|XM_006240284.2|",3465,0,"PREDICTED: Rattus norvegicus SPARC related modular calcium binding 1 (Smoc1), transcript variant X1, mRNA","Q8BLY1",888,0,"SPARC-related modular calcium-binding protein 1",".",".",".",".","pfam00086","Thyroglobulin_1","Thyroglobulin type-1 repeat. Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.","GO:0001654|eye development;GO:0010811|positive regulation of cell-substrate adhesion;GO:0030198|extracellular matrix organization;GO:0045667|regulation of osteoblast differentiation;GO:0060173|limb development;","GO:0005604|basement membrane;GO:0005615|extracellular space;","GO:0005509|calcium ion binding;GO:0008201|heparin binding;GO:0050840|extracellular matrix binding;","K24354","SMOC; SPARC-related modular calcium-binding protein"]
["ENSRNOG00000021524",5248,337.6061396,470,30.34407404,11.12593316,3.475854439,0,0,"up","yes","Mrap","protein_coding","chr11:29992034-30003024:+","gi|149059808|gb|EDM10691.1|",794,{"v":2e-101,"d":"2.00E-101"},"melanocortin 2 receptor accessory protein (predicted), isoform CRA_b [Rattus norvegicus]","gi|209447106|ref|NM_001135834.1|",836,0,"Rattus norvegicus melanocortin 2 receptor accessory protein (Mrap), mRNA","Q9D159",184,{"v":1E-54,"d":"1.00E-54"},"Melanocortin-2 receptor accessory protein",".",".",".",".","pfam15183","MRAP","Melanocortin-2 receptor accessory protein family. This family is thought to be involved in cell trafficking. It is required for MC2R expression in certain cell types, suggesting that it is involved in the processing, trafficking or function of MC2R. MRAP may be involved in the intracellular trafficking pathways in adipocyte cells. This family of proteins is found in eukaryotes. Proteins in this family are typically between 47 and 205 amino acids in length.","GO:0008150|biological_process;GO:0050873|brown fat cell differentiation;GO:0072659|protein localization to plasma membrane;GO:0106070|regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0106071|positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0106072|negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:1903077|negative regulation of protein localization to plasma membrane;","GO:0005575|cellular_component;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0003674|molecular_function;GO:0030545|receptor regulator activity;GO:0031780|corticotropin hormone receptor binding;GO:0031781|type 3 melanocortin receptor binding;GO:0031782|type 4 melanocortin receptor binding;GO:0031783|type 5 melanocortin receptor binding;GO:0042802|identical protein binding;GO:0070996|type 1 melanocortin receptor binding;","K22398","MRAP; melanocortin 2 receptor accessory protein"]
["ENSRNOG00000050585",14383,925.2646924,5148,332.3644535,2.78388583,1.477100046,0,0,"up","yes","Pgam1","protein_coding","chr1:240723920-240738452:+","gi|403259801|ref|XP_003922386.1|",1340,{"v":1E-179,"d":"1.00E-179"},"PREDICTED: phosphoglycerate mutase 1 [Saimiri boliviensis boliviensis]","gi|924183756|ref|NM_053290.2|",1708,0,"Rattus norvegicus phosphoglycerate mutase 1 (Pgam1), mRNA","P25113",501,{"v":3e-174,"d":"3.00E-174"},"Phosphoglycerate mutase 1","gpmA",291,{"v":4e-93,"d":"4.00E-93"},"COG0588","pfam00300","His_Phos_1","Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centres on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.","GO:0006096|glycolytic process;GO:0006110|regulation of glycolytic process;GO:0043456|regulation of pentose-phosphate shunt;GO:0045730|respiratory burst;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004082|bisphosphoglycerate mutase activity;GO:0004619|phosphoglycerate mutase activity;GO:0016787|hydrolase activity;GO:0019901|protein kinase binding;","K01834","PGAM, gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]"]
["ENSRNOG00000014948",4643,298.6862245,307,19.82049091,15.06956744,3.913566101,0,0,"up","yes","Osgin1","protein_coding","chr19:47492171-47500516:+","gi|19923094|ref|NP_612513.1|",2364,0,"oxidative stress-induced growth inhibitor 1 [Rattus norvegicus]","gi|672085169|ref|XM_006255707.2|",1735,0,"PREDICTED: Rattus norvegicus oxidative stress induced growth inhibitor 1 (Osgin1), transcript variant X3, mRNA","Q9UJX0",762,0,"Oxidative stress-induced growth inhibitor 1","BH1623",56.6,1e-07,"COG0492","pfam13738","Pyr_redox_3","Pyridine nucleotide-disulphide oxidoreductase.","GO:0007165|signal transduction;GO:0030308|negative regulation of cell growth;GO:0030334|regulation of cell migration;GO:0042127|regulation of cell proliferation;GO:0042981|regulation of apoptotic process;GO:0043065|positive regulation of apoptotic process;",".","GO:0008083|growth factor activity;",".","."]
["ENSRNOG00000047098",4055,260.8599268,137,8.844974773,29.49244442,4.882273497,0,0,"up","yes","Hbb-b1","protein_coding","chr1:158120200-158252012:-","gi|40445397|ref|NP_942071.1|",744,{"v":1e-96,"d":"1.00E-96"},"hemoglobin, beta adult major chain [Rattus norvegicus]","gi|298901836|emb|FQ228130.1|",564,0,"Rattus norvegicus TL0AEA10YG08 mRNA sequence","P11517",284,{"v":2E-95,"d":"2.00E-95"},"Hemoglobin subunit beta-2",".",".",".",".","pfam00042","Globin","Globin.","GO:0015671|oxygen transport;GO:0098869|cellular oxidant detoxification;","GO:0005833|hemoglobin complex;","GO:0005344|oxygen carrier activity;GO:0019825|oxygen binding;GO:0020037|heme binding;GO:0046872|metal ion binding;","K13823","HBB; hemoglobin subunit beta"]
["ENSRNOG00000017481",7053,453.7225805,1336,86.2546445,5.260268397,2.395136413,0,0,"up","yes","Sucla2","protein_coding","chr15:48752312-48805138:+","gi|158749584|ref|NP_001101857.2|",2242,0,"succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial [Rattus norvegicus]","gi|158749583|ref|NM_001108387.2|",1325,0,"Rattus norvegicus succinate-CoA ligase, ADP-forming, beta subunit (Sucla2), mRNA","Q9Z2I9",832,0,"Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial","SPCC1620.08",448,{"v":8e-149,"d":"8.00E-149"},"COG0045","pfam08442","ATP-grasp_2","ATP-grasp domain.","GO:0006099|tricarboxylic acid cycle;GO:0006104|succinyl-CoA metabolic process;GO:0006105|succinate metabolic process;","GO:0005739|mitochondrion;GO:0042709|succinate-CoA ligase complex;","GO:0000287|magnesium ion binding;GO:0004775|succinate-CoA ligase (ADP-forming) activity;GO:0004776|succinate-CoA ligase (GDP-forming) activity;GO:0005524|ATP binding;","K01900","LSC2; succinyl-CoA synthetase beta subunit [EC:6.2.1.4 6.2.1.5]"]
["ENSRNOG00000010958",7761,499.2685308,1691,109.1741047,4.573140602,2.193185276,0,0,"up","yes","Prdx3","protein_coding","chr1:260001637-260014111:-","gi|149040547|gb|EDL94585.1|",1321,{"v":2E-179,"d":"2.00E-179"},"peroxiredoxin 3 [Rattus norvegicus]","gi|298913927|emb|FQ219655.1|",1348,0,"Rattus norvegicus TL0ABA43YM21 mRNA sequence","Q9Z0V6",510,{"v":1E-179,"d":"1.00E-179"},"Thioredoxin-dependent peroxide reductase, mitochondrial","SPCC576.03c",233,{"v":8E-73,"d":"8.00E-73"},"COG0450","pfam00578","AhpC-TSA","AhpC/TSA family. This family contains proteins related to alkyl hydroperoxide reductase (AhpC) and thiol specific antioxidant (TSA).","GO:0001893|maternal placenta development;GO:0006915|apoptotic process;GO:0006979|response to oxidative stress;GO:0007005|mitochondrion organization;GO:0008284|positive regulation of cell proliferation;GO:0018171|peptidyl-cysteine oxidation;GO:0030099|myeloid cell differentiation;GO:0032496|response to lipopolysaccharide;GO:0033673|negative regulation of kinase activity;GO:0034599|cellular response to oxidative stress;GO:0034614|cellular response to reactive oxygen species;GO:0042542|response to hydrogen peroxide;GO:0042744|hydrogen peroxide catabolic process;GO:0043066|negative regulation of apoptotic process;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043524|negative regulation of neuron apoptotic process;GO:0045454|cell redox homeostasis;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051881|regulation of mitochondrial membrane potential;GO:0098869|cellular oxidant detoxification;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005769|early endosome;GO:0005829|cytosol;GO:0032991|protein-containing complex;","GO:0003674|molecular_function;GO:0008022|protein C-terminus binding;GO:0008379|thioredoxin peroxidase activity;GO:0019900|kinase binding;GO:0019901|protein kinase binding;GO:0042802|identical protein binding;GO:0043027|cysteine-type endopeptidase inhibitor activity involved in apoptotic process;","K20011","PRDX3; peroxiredoxin 3 [EC:1.11.1.24 1.11.1.25]"]
["ENSRNOG00000001052",6026,387.6552205,968,62.49588015,6.202892408,2.632941101,0,0,"up","yes","Slc25a30","protein_coding","chr15:51077002-51099613:-","gi|61557225|ref|NP_001013205.1|",1518,0,"kidney mitochondrial carrier protein 1 [Rattus norvegicus]","gi|52631145|gb|AY724532.1|",3519,0,"Rattus norvegicus clone UI-R-FJ0-cqa-n-24-0-UI unknown mRNA","Q5PQM9",589,0,"Kidney mitochondrial carrier protein 1",".",".",".",".","pfam00153","Mito_carr","Mitochondrial carrier protein.","GO:0006839|mitochondrial transport;GO:0008272|sulfate transport;GO:0015709|thiosulfate transport;GO:0015729|oxaloacetate transport;GO:0035435|phosphate ion transmembrane transport;GO:0071422|succinate transmembrane transport;GO:0071423|malate transmembrane transport;GO:1902356|oxaloacetate(2-) transmembrane transport;GO:1902358|sulfate transmembrane transport;","GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0016021|integral component of membrane;GO:0031966|mitochondrial membrane;","GO:0015116|sulfate transmembrane transporter activity;GO:0015117|thiosulfate transmembrane transporter activity;GO:0015131|oxaloacetate transmembrane transporter activity;GO:0015140|malate transmembrane transporter activity;GO:0015141|succinate transmembrane transporter activity;GO:0015297|antiporter activity;","K15106","SLC25A14_30; solute carrier family 25 (mitochondrial carrier), member 14/30"]
["ENSRNOG00000062369",6006,386.3686117,1071,69.14575169,5.587741868,2.482265375,0,0,"up","yes","ENSRNOG00000062369","lncRNA","chr8:40654151-40657024:-",".",".",".",".","gi|672061528|ref|XM_008766121.1|",2533,0,"PREDICTED: Rattus norvegicus GRAM domain containing 1B (Gramd1b), transcript variant X7, mRNA",".",".",".",".",".",".",".",".","pfam03154","Atrophin-1","Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.",".",".",".",".","."]
["ENSRNOG00000020776",6795,437.1253275,1486,95.93892345,4.556287602,2.187858816,0,0,"up","yes","Dhcr7","protein_coding","chr1:199015081-199031055:+","gi|672039485|ref|XP_008758392.1|",2412,0,"PREDICTED: 7-dehydrocholesterol reductase isoform X2 [Rattus norvegicus]","gi|31542554|ref|NM_022389.2|",2712,0,"Rattus norvegicus 7-dehydrocholesterol reductase (Dhcr7), mRNA","Q9Z2Z8",927,0,"7-dehydrocholesterol reductase",".",".",".",".","pfam01222","ERG4_ERG24","Ergosterol biosynthesis ERG4/ERG24 family.","GO:0001568|blood vessel development;GO:0006695|cholesterol biosynthetic process;GO:0009791|post-embryonic development;GO:0016126|sterol biosynthetic process;GO:0016132|brassinosteroid biosynthetic process;GO:0030154|cell differentiation;GO:0030324|lung development;GO:0035264|multicellular organism growth;GO:0042127|regulation of cell proliferation;GO:0045540|regulation of cholesterol biosynthetic process;","GO:0005640|nuclear outer membrane;GO:0005783|endoplasmic reticulum;GO:0030176|integral component of endoplasmic reticulum membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0009918|sterol delta7 reductase activity;GO:0016627|oxidoreductase activity, acting on the CH-CH group of donors;GO:0047598|7-dehydrocholesterol reductase activity;GO:0050661|NADP binding;","K00213","DHCR7; 7-dehydrocholesterol reductase [EC:1.3.1.21]"]
["ENSRNOG00000058249",10098,649.6087648,3415,220.4787507,2.946355432,1.55893148,0,0,"up","yes","ENSRNOG00000058249","protein_coding","chrX:71271440-71287418:+","gi|40254752|ref|NP_445743.2|",1997,0,"phosphoglycerate kinase 1 [Rattus norvegicus]","gi|38649309|gb|BC063161.1|",1206,0,"Rattus norvegicus phosphoglycerate kinase 1, mRNA (cDNA clone MGC:72752 IMAGE:6921844), complete cds","P16617",773,0,"Phosphoglycerate kinase 1","SPBC14F5.04c",511,{"v":1E-175,"d":"1.00E-175"},"COG0126","pfam00162","PGK","Phosphoglycerate kinase.","GO:0005975|carbohydrate metabolic process;GO:0006094|gluconeogenesis;GO:0006096|glycolytic process;GO:0016310|phosphorylation;GO:0016525|negative regulation of angiogenesis;GO:0030855|epithelial cell differentiation;GO:0031639|plasminogen activation;GO:0071456|cellular response to hypoxia;","GO:0005615|extracellular space;GO:0005829|cytosol;GO:0045121|membrane raft;","GO:0004618|phosphoglycerate kinase activity;GO:0005524|ATP binding;GO:0043531|ADP binding;GO:0047134|protein-disulfide reductase activity;","K00927","PGK, pgk; phosphoglycerate kinase [EC:2.7.2.3]"]
["ENSRNOG00000004111",9986,642.4037557,3392,218.993828,2.933433155,1.552590117,0,0,"up","yes","Soat1","protein_coding","chr13:68552317-68597494:-","gi|149058327|gb|EDM09484.1|",2773,0,"sterol O-acyltransferase 1, isoform CRA_a [Rattus norvegicus]","gi|672074543|ref|XM_008769681.1|",4143,0,"PREDICTED: Rattus norvegicus sterol O-acyltransferase 1 (Soat1), transcript variant X1, mRNA","O70536",1062,0,"Sterol O-acyltransferase 1","YNR019w",113,{"v":1e-24,"d":"1.00E-24"},"COG5056","pfam03062","MBOAT","MBOAT, membrane-bound O-acyltransferase family. The MBOAT (membrane bound O-acyl transferase) family of membrane proteins contains a variety of acyltransferase enzymes. A conserved histidine has been suggested to be the active site residue.","GO:0008203|cholesterol metabolic process;GO:0010742|macrophage derived foam cell differentiation;GO:0010878|cholesterol storage;GO:0033344|cholesterol efflux;GO:0034379|very-low-density lipoprotein particle assembly;GO:0034435|cholesterol esterification;GO:0042632|cholesterol homeostasis;GO:0042986|positive regulation of amyloid precursor protein biosynthetic process;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0000062|fatty-acyl-CoA binding;GO:0004772|sterol O-acyltransferase activity;GO:0008374|O-acyltransferase activity;GO:0015485|cholesterol binding;GO:0034736|cholesterol O-acyltransferase activity;GO:0042802|identical protein binding;","K00637","SOAT; sterol O-acyltransferase [EC:2.3.1.26]"]
["ENSRNOG00000052219",12698,816.8679041,5113,330.1047884,2.474571508,1.307178733,0,0,"up","yes","Gm2a","protein_coding","chr10:39219243-39231757:+","gi|48976085|ref|NP_758838.2|",852,{"v":7e-107,"d":"7.00E-107"},"ganglioside GM2 activator precursor [Rattus norvegicus]","gi|48976084|ref|NM_172335.2|",1959,0,"Rattus norvegicus GM2 ganglioside activator (Gm2a), mRNA","Q60648",305,{"v":5e-98,"d":"5.00E-98"},"Ganglioside GM2 activator",".",".",".",".","pfam02221","E1_DerP2_DerF2","ML domain. ML domain - MD-2-related lipid recognition domain. This family consists of proteins from plants, animals and fungi, including dust mite allergen Der P 2. It has been implicate in lipid recognition, particularly in the recognition of pathogen related products. A mutation in Npc2 causes a rare form of Niemann-Pick type C2 disease. This domain has a similar topology to immunoglobulin domains.","GO:0001573|ganglioside metabolic process;GO:0006689|ganglioside catabolic process;GO:0006869|lipid transport;GO:0007611|learning or memory;GO:0009313|oligosaccharide catabolic process;GO:0019915|lipid storage;GO:0050877|nervous system process;GO:0050885|neuromuscular process controlling balance;GO:0051345|positive regulation of hydrolase activity;","GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0005829|cytosol;GO:0009898|cytoplasmic side of plasma membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0004563|beta-N-acetylhexosaminidase activity;GO:0005319|lipid transporter activity;GO:0008047|enzyme activator activity;GO:0008289|lipid binding;GO:0016004|phospholipase activator activity;GO:0032428|beta-N-acetylgalactosaminidase activity;","K12383","GM2A; ganglioside GM2 activator"]
["ENSRNOG00000006787",4205,270.5094926,492,31.76443495,8.516112218,3.09019496,0,0,"up","yes","Dhcr24","protein_coding","chr5:121344575-121371137:+","gi|37359736|dbj|BAC97846.1|",2788,0,"mKIAA0018 protein [Mus musculus]","gi|625266931|ref|XM_007626773.1|",1896,0,"PREDICTED: Cricetulus griseus 24-dehydrocholesterol reductase (Dhcr24), mRNA","Q5BQE6",1072,0,"Delta(24)-sterol reductase","Cgl0556",131,{"v":5e-31,"d":"5.00E-31"},"COG0277","pfam01565","FAD_binding_4","FAD binding domain. This family consists of various enzymes that use FAD as a co-factor, most of the enzymes are similar to oxygen oxidoreductase. One of the enzymes Vanillyl-alcohol oxidase (VAO) has a solved structure, the alignment includes the FAD binding site, called the PP-loop, between residues 99-110. The FAD molecule is covalently bound in the known structure, however the residue that links to the FAD is not in the alignment. VAO catalyses the oxidation of a wide variety of substrates, ranging form aromatic amines to 4-alkylphenols. Other members of this family include D-lactate dehydrogenase, this enzyme catalyses the conversion of D-lactate to pyruvate using FAD as a co-factor; mitomycin radical oxidase, this enzyme oxidizes the reduced form of mitomycins and is involved in mitomycin resistance. This family includes MurB an UDP-N-acetylenolpyruvoylglucosamine reductase enzyme EC:1.1.1.158. This enzyme is involved in the biosynthesis of peptidoglycan.","GO:0006695|cholesterol biosynthetic process;GO:0006979|response to oxidative stress;GO:0007265|Ras protein signal transduction;GO:0008104|protein localization;GO:0008202|steroid metabolic process;GO:0008203|cholesterol metabolic process;GO:0008285|negative regulation of cell proliferation;GO:0009725|response to hormone;GO:0009888|tissue development;GO:0016125|sterol metabolic process;GO:0030539|male genitalia development;GO:0031639|plasminogen activation;GO:0033489|cholesterol biosynthetic process via desmosterol;GO:0042987|amyloid precursor protein catabolic process;GO:0043066|negative regulation of apoptotic process;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043588|skin development;GO:0061024|membrane organization;","GO:0000139|Golgi membrane;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0000246|delta24(24-1) sterol reductase activity;GO:0016491|oxidoreductase activity;GO:0016628|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor;GO:0019899|enzyme binding;GO:0042605|peptide antigen binding;GO:0050614|delta24-sterol reductase activity;GO:0071949|FAD binding;","K09828","DHCR24, DWF1; Delta24-sterol reductase [EC:1.3.1.72 1.3.1.-]"]
["ENSRNOG00000005387",11445,736.261865,4382,282.910069,2.602459034,1.379875454,0,0,"up","yes","ENSRNOG00000005387","protein_coding","chrX:14348910-14353580:+","gi|148702008|gb|EDL33955.1|",492,{"v":8e-54,"d":"8.00E-54"},"mCG116386, isoform CRA_e, partial [Mus musculus]","gi|564398624|ref|XM_006256694.1|",686,0,"PREDICTED: Rattus norvegicus RNA binding motif (RNP1, RRM) protein 3 (Rbm3), transcript variant X1, mRNA","O89086",177,{"v":9e-50,"d":"9.00E-50"},"RNA-binding protein 3","TP0356",72.4,{"v":8E-14,"d":"8.00E-14"},"COG0724","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0006412|translation;GO:0006417|regulation of translation;GO:0009409|response to cold;GO:0035196|production of miRNAs involved in gene silencing by miRNA;GO:0045727|positive regulation of translation;GO:0048026|positive regulation of mRNA splicing, via spliceosome;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005681|spliceosomal complex;GO:0005737|cytoplasm;GO:0030425|dendrite;","GO:0003723|RNA binding;GO:0005515|protein binding;GO:0043023|ribosomal large subunit binding;","K13186","RBM3; RNA-binding protein 3"]
["ENSRNOG00000014765",8795,565.7862038,2836,183.097434,3.090082649,1.627645426,0,0,"up","yes","Vapa","protein_coding","chr9:105177907-105207847:-","gi|672066195|ref|XP_008765606.1|",1325,{"v":1e-177,"d":"1.00E-177"},"PREDICTED: vesicle-associated membrane protein-associated protein A isoform X1 [Rattus norvegicus]","gi|672066194|ref|XM_008767384.1|",1725,0,"PREDICTED: Rattus norvegicus VAMP (vesicle-associated membrane protein)-associated protein A (Vapa), transcript variant X1, mRNA","Q9Z270",451,{"v":5e-155,"d":"5.00E-155"},"Vesicle-associated membrane protein-associated protein A","SPAC17C9.12",92,{"v":2E-19,"d":"2.00E-19"},"COG5066","pfam00635","Motile_Sperm","MSP (Major sperm protein) domain. Major sperm proteins are involved in sperm motility. These proteins oligomerise to form filaments. This family contains many other proteins.","GO:0006888|ER to Golgi vesicle-mediated transport;GO:0008219|cell death;GO:0031175|neuron projection development;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0044791|positive regulation by host of viral release from host cell;GO:0044828|negative regulation by host of viral genome replication;GO:0044829|positive regulation by host of viral genome replication;GO:0070972|protein localization to endoplasmic reticulum;GO:0090114|COPII-coated vesicle budding;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0005923|bicellular tight junction;GO:0015630|microtubule cytoskeleton;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0031965|nuclear membrane;GO:0031982|vesicle;GO:0048471|perinuclear region of cytoplasm;GO:0070382|exocytic vesicle;","GO:0005515|protein binding;GO:0008017|microtubule binding;GO:0019904|protein domain specific binding;GO:0033149|FFAT motif binding;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;GO:0046982|protein heterodimerization activity;","K06096","VAPA; vesicle-associated membrane protein-associated protein A"]
["ENSRNOG00000065713",9051,582.254796,3149,203.3052961,2.863943081,1.51800282,0,0,"up","yes","Chchd2","protein_coding","chr12:26828736-26834755:+","gi|62543533|ref|NP_001015019.1|",473,{"v":1e-55,"d":"1.00E-55"},"coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial [Rattus norvegicus]","gi|672026695|ref|XR_590631.1|",704,0,"PREDICTED: Rattus norvegicus coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial-like (LOC100910788), misc_RNA","Q9D1L0",172,{"v":9e-52,"d":"9.00E-52"},"Coiled-coil-helix-coiled-coil-helix domain-containing protein 2",".",".",".",".","pfam06747","CHCH","CHCH domain. we have identified a conserved motif in the LOC118487 protein that we have called the CHCH motif. Alignment of this protein with related members showed the presence of three subgroups of proteins, which are called the S (Small), N (N-terminal extended) and C (C-terminal extended) subgroups. All three sub-groups of proteins have in common that they contain a predicted conserved [coiled coil 1]-[helix 1]-[coiled coil 2]-[helix 2] domain (CHCH domain). Within each helix of the CHCH domain, there are two cysteines present in a C-X9-C motif. The N-group contains an additional double helix domain, and each helix contains the C-X9-C motif. This family contains a number of characterized proteins: Cox19 protein - a nuclear gene of Saccharomyces cerevisiae, codes for an 11-kDa protein (Cox19p) required for expression of cytochrome oxidase. Because cox19 mutants are able to synthesize the mitochondrial and nuclear gene products of cytochrome oxidase, Cox19p probably functions post-translationally during assembly of the enzyme. Cox19p is present in the cytoplasm and mitochondria, where it exists as a soluble intermembrane protein. This dual location is similar to what was previously reported for Cox17p, a low molecular weight copper protein thought to be required for maturation of the CuA centre of subunit 2 of cytochrome oxidase. Cox19p have four conserved potential metal ligands, these are three cysteines and one histidine. Mrp10 - belongs to the class of yeast mitochondrial ribosomal proteins that are essential for translation. Eukaryotic NADH-ubiquinone oxidoreductase 19 kDa (NDUFA8) subunit. The CHCH domain was previously called DUF657.",".",".",".",".","."]
["ENSRNOG00000014456",3918,252.0466568,505,32.60373913,7.730605862,2.950581485,0,0,"up","yes","Coq10b","protein_coding","chr9:56553758-56573663:+","gi|57528275|ref|NP_001009671.1|",1086,{"v":6e-143,"d":"6.00E-143"},"coenzyme Q-binding protein COQ10 homolog B, mitochondrial [Rattus norvegicus]","gi|57528274|ref|NM_001009671.1|",1600,0,"Rattus norvegicus coenzyme Q10B (Coq10b), mRNA","Q5I0I9",422,{"v":3e-144,"d":"3.00E-144"},"Coenzyme Q-binding protein COQ10 homolog B, mitochondrial","RSc1425",75.9,{"v":4e-15,"d":"4.00E-15"},"COG2867","pfam03364","Polyketide_cyc","Polyketide cyclase / dehydrase and lipid transport. This family contains polyketide cylcases/dehydrases which are enzymes involved in polyketide synthesis. The family also includes proteins which are involved in the binding/transport of lipids.","GO:0006744|ubiquinone biosynthetic process;GO:0045333|cellular respiration;","GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;","GO:0048039|ubiquinone binding;","K18588","COQ10; coenzyme Q-binding protein COQ10"]
["ENSRNOG00000031955",4146,266.7139967,609,39.31817253,6.783478976,2.762025364,0,0,"up","yes","Calml3","protein_coding","chr17:66419882-66423175:+","gi|58865676|ref|NP_001012054.1|",782,{"v":2E-95,"d":"2.00E-95"},"calmodulin-like protein 3 [Rattus norvegicus]","gi|672082420|ref|XM_006254208.2|",1861,0,"PREDICTED: Rattus norvegicus calmodulin-like 3 (Calml3), transcript variant X1, mRNA","Q5U206",305,{"v":7e-97,"d":"7.00E-97"},"Calmodulin-like protein 3","SPAC3A12.14",226,{"v":4e-68,"d":"4.00E-68"},"COG5126","pfam13499","EF-hand_7","EF-hand domain pair.","GO:0008150|biological_process;GO:0050790|regulation of catalytic activity;","GO:0005575|cellular_component;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;GO:0030234|enzyme regulator activity;","K02183","CALM; calmodulin"]
["ENSRNOG00000009339",3945,253.7835786,532,34.34690934,7.388833043,2.88534653,0,0,"up","yes","Cenpe","protein_coding","chr2:223636998-223695669:+","gi|672044374|ref|XP_006233412.2|",11903,0,"PREDICTED: centromere-associated protein E isoform X2 [Rattus norvegicus]","gi|672044373|ref|XM_006233350.2|",7599,0,"PREDICTED: Rattus norvegicus centromere protein E (Cenpe), transcript variant X2, mRNA","Q6RT24",3648,0,"Centromere-associated protein E","SPAC1834.07",222,{"v":7e-60,"d":"7.00E-60"},"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0000278|mitotic cell cycle;GO:0007018|microtubule-based movement;GO:0007052|mitotic spindle organization;GO:0007057|spindle assembly involved in female meiosis I;GO:0007059|chromosome segregation;GO:0007079|mitotic chromosome movement towards spindle pole;GO:0007080|mitotic metaphase plate congression;GO:0007088|regulation of mitotic nuclear division;GO:0007094|mitotic spindle assembly checkpoint;GO:0008608|attachment of spindle microtubules to kinetochore;GO:0030071|regulation of mitotic metaphase/anaphase transition;GO:0031647|regulation of protein stability;GO:0045184|establishment of protein localization;GO:0045842|positive regulation of mitotic metaphase/anaphase transition;GO:0045860|positive regulation of protein kinase activity;GO:0050793|regulation of developmental process;GO:0051310|metaphase plate congression;GO:0051315|attachment of mitotic spindle microtubules to kinetochore;GO:0051382|kinetochore assembly;GO:0051984|positive regulation of chromosome segregation;GO:0051987|positive regulation of attachment of spindle microtubules to kinetochore;GO:0099606|microtubule plus-end directed mitotic chromosome migration;GO:0099607|lateral attachment of mitotic spindle microtubules to kinetochore;","GO:0000775|chromosome, centromeric region;GO:0000776|kinetochore;GO:0000779|condensed chromosome, centromeric region;GO:0000940|condensed chromosome outer kinetochore;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005694|chromosome;GO:0005828|kinetochore microtubule;GO:0005829|cytosol;GO:0005874|microtubule;GO:0015630|microtubule cytoskeleton;GO:0030496|midbody;GO:0051233|spindle midzone;GO:1990023|mitotic spindle midzone;","GO:0003777|microtubule motor activity;GO:0005524|ATP binding;GO:0008017|microtubule binding;GO:0008574|ATP-dependent microtubule motor activity, plus-end-directed;GO:0019901|protein kinase binding;GO:0043515|kinetochore binding;","K11498","CENPE; centromeric protein E"]
["ENSRNOG00000022523",5943,382.3157941,1458,94.13119138,4.061520826,2.022020042,0,0,"up","yes","Fkbp5","protein_coding","chr20:6457216-6541674:-","gi|564397283|ref|XP_006256284.1|",2387,0,"PREDICTED: peptidyl-prolyl cis-trans isomerase FKBP5 isoform X2 [Rattus norvegicus]","gi|672086007|ref|XM_006256224.2|",3383,0,"PREDICTED: Rattus norvegicus FK506 binding protein 5 (Fkbp5), transcript variant X2, mRNA","Q64378",842,0,"Peptidyl-prolyl cis-trans isomerase FKBP5","slr1761",110,{"v":9e-26,"d":"9.00E-26"},"COG0545","pfam00254","FKBP_C","FKBP-type peptidyl-prolyl cis-trans isomerase.","GO:0000413|protein peptidyl-prolyl isomerization;GO:0008150|biological_process;GO:0009617|response to bacterium;GO:0061077|chaperone-mediated protein folding;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;","GO:0003674|molecular_function;GO:0003755|peptidyl-prolyl cis-trans isomerase activity;GO:0005528|FK506 binding;GO:0031072|heat shock protein binding;","K09571","FKBP4_5; FK506-binding protein 4/5 [EC:5.2.1.8]"]
["ENSRNOG00000006589",8807,566.5581691,3087,199.3024608,2.842705338,1.507264564,0,0,"up","yes","Mif","protein_coding","chr20:12790902-12799504:+","gi|13591985|ref|NP_112313.1|",620,{"v":1E-79,"d":"1.00E-79"},"macrophage migration inhibitory factor [Rattus norvegicus]","gi|672089646|ref|XM_008773846.1|",569,0,"PREDICTED: Rattus norvegicus macrophage migration inhibitory factor (LOC103694877), mRNA","P30904",243,{"v":4e-81,"d":"4.00E-81"},"Macrophage migration inhibitory factor",".",".",".",".","pfam01187","MIF","Macrophage migration inhibitory factor (MIF).","GO:0001516|prostaglandin biosynthetic process;GO:0001819|positive regulation of cytokine production;GO:0001934|positive regulation of protein phosphorylation;GO:0001942|hair follicle development;GO:0002035|brain renin-angiotensin system;GO:0002675|positive regulation of acute inflammatory response;GO:0002906|negative regulation of mature B cell apoptotic process;GO:0006954|inflammatory response;GO:0007166|cell surface receptor signaling pathway;GO:0007283|spermatogenesis;GO:0007420|brain development;GO:0007568|aging;GO:0007569|cell aging;GO:0009408|response to heat;GO:0009410|response to xenobiotic stimulus;GO:0009612|response to mechanical stimulus;GO:0009725|response to hormone;GO:0010035|response to inorganic substance;GO:0010629|negative regulation of gene expression;GO:0010739|positive regulation of protein kinase A signaling;GO:0010760|negative regulation of macrophage chemotaxis;GO:0014911|positive regulation of smooth muscle cell migration;GO:0019752|carboxylic acid metabolic process;GO:0030330|DNA damage response, signal transduction by p53 class mediator;GO:0030336|negative regulation of cell migration;GO:0030890|positive regulation of B cell proliferation;GO:0031666|positive regulation of lipopolysaccharide-mediated signaling pathway;GO:0032269|negative regulation of cellular protein metabolic process;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0032570|response to progesterone;GO:0032572|response to menaquinone;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032868|response to insulin;GO:0033033|negative regulation of myeloid cell apoptotic process;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0033197|response to vitamin E;GO:0042060|wound healing;GO:0042127|regulation of cell proliferation;GO:0042327|positive regulation of phosphorylation;GO:0042756|drinking behavior;GO:0043066|negative regulation of apoptotic process;GO:0043268|positive regulation of potassium ion transport;GO:0043406|positive regulation of MAP kinase activity;GO:0043518|negative regulation of DNA damage response, signal transduction by p53 class mediator;GO:0043588|skin development;GO:0045087|innate immune response;GO:0045821|positive regulation of glycolytic process;GO:0046326|positive regulation of glucose import;GO:0048146|positive regulation of fibroblast proliferation;GO:0048680|positive regulation of axon regeneration;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050778|positive regulation of immune response;GO:0050918|positive chemotaxis;GO:0051384|response to glucocorticoid;GO:0051726|regulation of cell cycle;GO:0061078|positive regulation of prostaglandin secretion involved in immune response;GO:0061081|positive regulation of myeloid leukocyte cytokine production involved in immune response;GO:0070207|protein homotrimerization;GO:0070301|cellular response to hydrogen peroxide;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071456|cellular response to hypoxia;GO:0090238|positive regulation of arachidonic acid secretion;GO:0090344|negative regulation of cell aging;GO:1902166|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:2000343|positive regulation of chemokine (C-X-C motif) ligand 2 production;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0009986|cell surface;","GO:0002020|protease binding;GO:0004167|dopachrome isomerase activity;GO:0005125|cytokine activity;GO:0005126|cytokine receptor binding;GO:0042056|chemoattractant activity;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;GO:0050178|phenylpyruvate tautomerase activity;","K07253","MIF; phenylpyruvate tautomerase [EC:5.3.2.1]"]
["ENSRNOG00000049911",4199,270.1235099,661,42.67538923,6.329725746,2.662142992,0,0,"up","yes","Cbr1","protein_coding","chr11:32857991-32895275:+","gi|564376239|ref|XP_006248171.1|",1663,0,"PREDICTED: carbonyl reductase [NADPH] 1 [Rattus norvegicus]","gi|1217650|emb|X95986.1|",1480,0,"R.norvegicus CBR gene","P47727",546,0,"Carbonyl reductase [NADPH] 1","all0352",126,{"v":1e-30,"d":"1.00E-30"},"COG1028","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.",".",".","GO:0004090|carbonyl reductase (NADPH) activity;GO:0016491|oxidoreductase activity;","K00079","CBR1; carbonyl reductase 1 [EC:1.1.1.184 1.1.1.189 1.1.1.197]"]
["ENSRNOG00000002469",5245,337.4131483,1176,75.92474695,4.444047057,2.151874093,0,0,"up","yes","Trim7","protein_coding","chr10:33205491-33221468:+","gi|149052383|gb|EDM04200.1|",2306,0,"rCG34252 [Rattus norvegicus]","gi|672024713|ref|XM_008774830.1|",2365,0,"PREDICTED: Rattus norvegicus tripartite motif-containing 7 (Trim7), mRNA","Q923T7",872,0,"E3 ubiquitin-protein ligase TRIM7",".",".",".",".","pfam00622","SPRY","SPRY domain. SPRY Domain is named from SPla and the RYanodine Receptor. Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.","GO:0016567|protein ubiquitination;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0008270|zinc ion binding;GO:0061630|ubiquitin protein ligase activity;","K12000","TRIM7; tripartite motif-containing protein 7"]
["ENSRNOG00000024629",8808,566.6224995,3169,204.5965332,2.769462857,1.46960619,0,0,"up","yes","Hadha","protein_coding","chr6:26187956-26227869:+","gi|148747393|ref|NP_570839.2|",3619,0,"trifunctional enzyme subunit alpha, mitochondrial precursor [Rattus norvegicus]","gi|510107|dbj|D16478.1|RATRTPA",2736,0,"Rattus norvegicus mRNA for mitochondrial long-chain enoyl-CoA hydRattus norvegicusase/3-hydroxyacyl-CoA dehydrogenase alpha-subunit of mitochondrial trifunctional protein, complete cds","Q64428",1398,0,"Trifunctional enzyme subunit alpha, mitochondrial","YPO2747_2",253,{"v":1E-73,"d":"1.00E-73"},"COG1250","pfam00378","ECH","Enoyl-CoA hydratase/isomerase family. This family contains a diverse set of enzymes including: Enoyl-CoA hydratase. Napthoate synthase. Carnitate racemase. 3-hydoxybutyryl-CoA dehydratase. Dodecanoyl-CoA delta-isomerase.","GO:0006635|fatty acid beta-oxidation;GO:0009410|response to xenobiotic stimulus;GO:0032868|response to insulin;GO:0035965|cardiolipin acyl-chain remodeling;","GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0016507|mitochondrial fatty acid beta-oxidation multienzyme complex;GO:0042645|mitochondrial nucleoid;","GO:0000062|fatty-acyl-CoA binding;GO:0003857|3-hydroxyacyl-CoA dehydrogenase activity;GO:0003988|acetyl-CoA C-acyltransferase activity;GO:0004300|enoyl-CoA hydratase activity;GO:0016508|long-chain-enoyl-CoA hydratase activity;GO:0016509|long-chain-3-hydroxyacyl-CoA dehydrogenase activity;GO:0044877|protein-containing complex binding;GO:0051287|NAD binding;GO:0070403|NAD+ binding;","K07515","HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]"]
["ENSRNOG00000010833",3073,197.6874365,254,16.39871235,12.05505849,3.591566745,0,0,"up","yes","Mthfd2","protein_coding","chr4:115811139-115822608:-","gi|157820897|ref|NP_001102868.1|",1717,0,"bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Rattus norvegicus]","gi|157820896|ref|NM_001109398.1|",1955,0,"Rattus norvegicus methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase (Mthfd2), mRNA","P18155",645,0,"Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial","BS_folD",264,{"v":2e-81,"d":"2.00E-81"},"COG0190","pfam02882","THF_DHG_CYH_C","Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain.","GO:0008150|biological_process;GO:0035999|tetrahydrofolate interconversion;GO:0046653|tetrahydrofolate metabolic process;","GO:0005575|cellular_component;GO:0005739|mitochondrion;","GO:0000287|magnesium ion binding;GO:0003674|molecular_function;GO:0004477|methenyltetrahydrofolate cyclohydrolase activity;GO:0004487|methylenetetrahydrofolate dehydrogenase (NAD+) activity;GO:0004488|methylenetetrahydrofolate dehydrogenase (NADP+) activity;GO:0042301|phosphate ion binding;","K13403","MTHFD2; methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.15 3.5.4.9]"]
["ENSRNOG00000012786",7929,510.0760444,2672,172.509289,2.956803354,1.564038299,0,0,"up","yes","Pgrmc1","protein_coding","chrX:115832884-115888682:+","gi|674035028|ref|XP_008842180.1|",902,{"v":7e-115,"d":"7.00E-115"},"PREDICTED: membrane-associated progesterone receptor component 1 [Nannospalax galili]","gi|38303844|gb|BC062073.1|",1813,0,"Rattus norvegicus progesterone receptor membrane component 1, mRNA (cDNA clone MGC:72462 IMAGE:5599449), complete cds","O55022",351,{"v":4E-116,"d":"4.00E-116"},"Membrane-associated progesterone receptor component 1",".",".",".",".","pfam00173","Cyt-b5","Cytochrome b5-like Heme/Steroid binding domain. This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases. There is no known ligand for this domain in the chitin synthases.","GO:0006783|heme biosynthetic process;GO:0007411|axon guidance;GO:0007613|memory;GO:0008306|associative learning;GO:0099563|modification of synaptic structure;GO:1903078|positive regulation of protein localization to plasma membrane;GO:1905809|negative regulation of synapse organization;","GO:0005741|mitochondrial outer membrane;GO:0012505|endomembrane system;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030868|smooth endoplasmic reticulum membrane;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0044297|cell body;GO:0045202|synapse;","GO:0005496|steroid binding;GO:0020037|heme binding;GO:0042803|protein homodimerization activity;GO:0046872|metal ion binding;","K17278","PGRMC1_2; membrane-associated progesterone receptor component"]
["ENSRNOG00000057078",6659,428.3763879,2010,129.7693379,3.301060133,1.722929419,0,0,"up","yes","Ddit4","protein_coding","chr20:27891998-27894105:-","gi|21312868|ref|NP_083359.1|",1023,{"v":5e-133,"d":"5.00E-133"},"DNA damage-inducible transcript 4 protein [Mus musculus]","gi|451958083|ref|NM_080906.2|",1714,0,"Rattus norvegicus DNA-damage-inducible transcript 4 (Ddit4), mRNA","Q9D3F7",398,{"v":2e-134,"d":"2.00E-134"},"DNA damage-inducible transcript 4 protein",".",".",".",".","pfam07809","RTP801_C","RTP801 C-terminal region. The members of this family are sequences similar to the C-terminal region of RTP801, the protein product of a hypoxia-inducible factor 1 (HIF-1)- responsive gene. Two members of this family expressed by Drosophila melanogaster, Scylla and Charybde, are designated by the GenBank as Hox targets. RTP801 is thought to be involved in various cellular processes. Its overexpression caused the apoptosis- resistant phenotype in cycling cells, and apoptosis sensitivity in growth arrested cells. Moreover, the protein product of the mouse homolog of RTP801 (dig2 ) is thought to be induced by diverse apoptotic signals, and also by dexamethasone treatment.","GO:0001666|response to hypoxia;GO:0001764|neuron migration;GO:0006915|apoptotic process;GO:0007420|brain development;GO:0010801|negative regulation of peptidyl-threonine phosphorylation;GO:0030182|neuron differentiation;GO:0032006|regulation of TOR signaling;GO:0032007|negative regulation of TOR signaling;GO:0032984|protein-containing complex disassembly;GO:0033137|negative regulation of peptidyl-serine phosphorylation;GO:0042771|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0045820|negative regulation of glycolytic process;GO:0048011|neurotrophin TRK receptor signaling pathway;GO:0051607|defense response to virus;GO:0071549|cellular response to dexamethasone stimulus;GO:0072593|reactive oxygen species metabolic process;GO:1901216|positive regulation of neuron death;GO:1902532|negative regulation of intracellular signal transduction;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;","GO:0071889|14-3-3 protein binding;","K08270","DDIT4, REDD1; DNA-damage-inducible transcript 4"]
["ENSRNOG00000013521",2964,190.6754188,263,16.97976909,11.22956489,3.489230124,0,0,"up","yes","Dhfr","protein_coding","chr2:23586031-23613713:+","gi|18426814|ref|NP_569084.1|",990,{"v":6e-125,"d":"6.00E-125"},"dihydrofolate reductase [Rattus norvegicus]","gi|402744580|ref|NM_130400.2|",697,0,"Rattus norvegicus dihydrofolate reductase (Dhfr), mRNA","Q920D2",385,{"v":2e-126,"d":"2.00E-126"},"Dihydrofolate reductase","SPCC1223.08c_2",108,{"v":4e-25,"d":"4.00E-25"},"COG0262","pfam00186","DHFR_1","Dihydrofolate reductase.","GO:0006545|glycine biosynthetic process;GO:0006729|tetrahydrobiopterin biosynthetic process;GO:0006730|one-carbon metabolic process;GO:0017148|negative regulation of translation;GO:0031103|axon regeneration;GO:0031427|response to methotrexate;GO:0035094|response to nicotine;GO:0035999|tetrahydrofolate interconversion;GO:0046452|dihydrofolate metabolic process;GO:0046653|tetrahydrofolate metabolic process;GO:0046654|tetrahydrofolate biosynthetic process;GO:0046655|folic acid metabolic process;GO:0051000|positive regulation of nitric-oxide synthase activity;GO:2000121|regulation of removal of superoxide radicals;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;","GO:0000900|translation repressor activity, mRNA regulatory element binding;GO:0003729|mRNA binding;GO:0004146|dihydrofolate reductase activity;GO:0005542|folic acid binding;GO:0050661|NADP binding;GO:0051870|methotrexate binding;GO:0051871|dihydrofolic acid binding;GO:0070402|NADPH binding;GO:1990825|sequence-specific mRNA binding;","K00287","DHFR, folA; dihydrofolate reductase [EC:1.5.1.3]"]
["ENSRNOG00000007249",8461,544.2998375,3088,199.3670226,2.730139771,1.448974813,0,0,"up","yes","Cdkn1b","protein_coding","chr4:167760181-167764982:+","gi|148678587|gb|EDL10534.1|",1073,{"v":3e-140,"d":"3.00E-140"},"cyclin-dependent kinase inhibitor 1B, isoform CRA_a, partial [Mus musculus]","gi|148747345|ref|NM_031762.3|",1755,0,"Rattus norvegicus cyclin-dependent kinase inhibitor 1B (Cdkn1b), mRNA","P46414",396,{"v":6E-134,"d":"6.00E-134"},"Cyclin-dependent kinase inhibitor 1B",".",".",".",".","pfam02234","CDI","Cyclin-dependent kinase inhibitor. Cell cycle progression is negatively controlled by cyclin-dependent kinases inhibitors (CDIs). CDIs are involved in cell cycle arrest at the G1 phase.","GO:0000079|regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0000082|G1/S transition of mitotic cell cycle;GO:0001666|response to hypoxia;GO:0001890|placenta development;GO:0006813|potassium ion transport;GO:0007096|regulation of exit from mitosis;GO:0007219|Notch signaling pathway;GO:0007346|regulation of mitotic cell cycle;GO:0007507|heart development;GO:0007605|sensory perception of sound;GO:0008219|cell death;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0009410|response to xenobiotic stimulus;GO:0009749|response to glucose;GO:0010942|positive regulation of cell death;GO:0014070|response to organic cyclic compound;GO:0016310|phosphorylation;GO:0030308|negative regulation of cell growth;GO:0031116|positive regulation of microtubule polymerization;GO:0032355|response to estradiol;GO:0033673|negative regulation of kinase activity;GO:0042326|negative regulation of phosphorylation;GO:0043066|negative regulation of apoptotic process;GO:0043200|response to amino acid;GO:0043434|response to peptide hormone;GO:0045732|positive regulation of protein catabolic process;GO:0045736|negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045737|positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045786|negative regulation of cell cycle;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045930|negative regulation of mitotic cell cycle;GO:0046686|response to cadmium ion;GO:0048102|autophagic cell death;GO:0048839|inner ear development;GO:0050680|negative regulation of epithelial cell proliferation;GO:0051271|negative regulation of cellular component movement;GO:0051726|regulation of cell cycle;GO:0060770|negative regulation of epithelial cell proliferation involved in prostate gland development;GO:0071236|cellular response to antibiotic;GO:0071285|cellular response to lithium ion;GO:0071407|cellular response to organic cyclic compound;GO:1902746|regulation of lens fiber cell differentiation;GO:1902806|regulation of cell cycle G1/S phase transition;GO:1904030|negative regulation of cyclin-dependent protein kinase activity;GO:1904706|negative regulation of vascular smooth muscle cell proliferation;GO:1905179|negative regulation of cardiac muscle tissue regeneration;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005829|cytosol;GO:0031464|Cul4A-RING E3 ubiquitin ligase complex;GO:0032991|protein-containing complex;GO:0043231|intracellular membrane-bounded organelle;","GO:0004860|protein kinase inhibitor activity;GO:0004861|cyclin-dependent protein serine/threonine kinase inhibitor activity;GO:0005515|protein binding;GO:0016301|kinase activity;GO:0019901|protein kinase binding;GO:0019903|protein phosphatase binding;GO:0030332|cyclin binding;GO:0030544|Hsp70 protein binding;GO:0044877|protein-containing complex binding;GO:0051087|chaperone binding;","K06624","CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B"]
["ENSRNOG00000032297",3784,243.4263781,594,38.34974464,6.347535829,2.666196633,0,0,"up","yes","Msmo1","protein_coding","chr16:24980697-24998016:+","gi|18266684|ref|NP_543162.1|",1576,0,"methylsterol monooxygenase 1 [Rattus norvegicus]","gi|38649307|gb|BC063155.1|",1667,0,"Rattus norvegicus sterol-C4-methyl oxidase-like, mRNA (cDNA clone MGC:72715 IMAGE:6918081), complete cds","O35532",611,0,"Methylsterol monooxygenase 1","SPAC630.08c",194,{"v":1e-55,"d":"1.00E-55"},"COG3000","pfam04116","FA_hydroxylase","Fatty acid hydroxylase superfamily. This superfamily includes fatty acid and carotene hydroxylases and sterol desaturases. Beta-carotene hydroxylase is involved in zeaxanthin synthesis by hydroxylating beta-carotene, but the enzyme may be involved in other pathways. This family includes C-5 sterol desaturase and C-4 sterol methyl oxidase. Members of this family are involved in cholesterol biosynthesis and biosynthesis a plant cuticular wax. These enzymes contain two copies of a HXHH motif. Members of this family are integral membrane proteins.","GO:0006695|cholesterol biosynthetic process;GO:0016126|sterol biosynthetic process;","GO:0005789|endoplasmic reticulum membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0000254|C-4 methylsterol oxidase activity;GO:0005506|iron ion binding;GO:0016491|oxidoreductase activity;","K07750","MESO1, ERG25; methylsterol monooxygenase [EC:1.14.18.9]"]
["ENSRNOG00000011815",8162,525.0650365,2926,188.9080014,2.779474838,1.474812322,0,0,"up","yes","Sgk1","protein_coding","chr1:22980261-23098283:-","gi|564324822|ref|XP_006227785.1|",2682,0,"PREDICTED: serine/threonine-protein kinase Sgk1 isoform X2 [Rattus norvegicus]","gi|564324821|ref|XM_006227723.1|",3120,0,"PREDICTED: Rattus norvegicus serum/glucocorticoid regulated kinase 1 (Sgk1), transcript variant X2, mRNA","Q06226",781,0,"Serine/threonine-protein kinase Sgk1",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006468|protein phosphorylation;GO:0006883|cellular sodium ion homeostasis;GO:0006915|apoptotic process;GO:0006974|cellular response to DNA damage stimulus;GO:0007019|microtubule depolymerization;GO:0007616|long-term memory;GO:0008542|visual learning;GO:0010765|positive regulation of sodium ion transport;GO:0018105|peptidyl-serine phosphorylation;GO:0030307|positive regulation of cell growth;GO:0031115|negative regulation of microtubule polymerization;GO:0032869|cellular response to insulin stimulus;GO:0032880|regulation of protein localization;GO:0035556|intracellular signal transduction;GO:0043066|negative regulation of apoptotic process;GO:0043402|glucocorticoid mediated signaling pathway;GO:0048812|neuron projection morphogenesis;GO:0050775|positive regulation of dendrite morphogenesis;GO:0051726|regulation of cell cycle;GO:1904045|cellular response to aldosterone;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005789|endoplasmic reticulum membrane;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016607|nuclear speck;GO:0043005|neuron projection;GO:0048471|perinuclear region of cytoplasm;","GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0004712|protein serine/threonine/tyrosine kinase activity;GO:0005524|ATP binding;GO:0015459|potassium channel regulator activity;GO:0035091|phosphatidylinositol binding;GO:0043423|3-phosphoinositide-dependent protein kinase binding;GO:0048156|tau protein binding;","K13302","SGK1; serum/glucocorticoid-regulated kinase 1 [EC:2.7.11.1]"]
["ENSRNOG00000025406",4255,273.7260145,818,52.8116012,5.183065998,2.373805764,0,0,"up","yes","Iqgap2","protein_coding","chr2:26894825-27170279:-","gi|392345265|ref|XP_002729048.2|",7912,0,"PREDICTED: ras GTPase-activating-like protein IQGAP2 isoform X2 [Rattus norvegicus]","gi|564334909|ref|XM_002729002.3|",6077,0,"PREDICTED: Rattus norvegicus IQ motif containing GTPase activating protein 2 (Iqgap2), transcript variant X2, mRNA","Q3UQ44",2903,0,"Ras GTPase-activating-like protein IQGAP2","SPAC4F8.13c",330,{"v":5E-91,"d":"5.00E-91"},"COG5261","pfam00616","RasGAP","GTPase-activator protein for Ras-like GTPase. All alpha-helical domain that accelerates the GTPase activity of Ras, thereby \"switching\" it into an \"off\" position.","GO:0032956|regulation of actin cytoskeleton organization;GO:0034314|Arp2/3 complex-mediated actin nucleation;GO:0043087|regulation of GTPase activity;GO:0070493|thrombin-activated receptor signaling pathway;GO:2000249|regulation of actin cytoskeleton reorganization;","GO:0005737|cytoplasm;GO:0005874|microtubule;GO:0005902|microvillus;GO:0009986|cell surface;GO:0030027|lamellipodium;GO:0030175|filopodium;","GO:0005096|GTPase activator activity;GO:0005516|calmodulin binding;GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;GO:0031267|small GTPase binding;GO:0051015|actin filament binding;GO:0071933|Arp2/3 complex binding;","K05767","IQGAP2_3; Ras GTPase-activating-like protein IQGAP2/3"]
["ENSRNOG00000021027",3682,236.8646734,566,36.54201256,6.481982156,2.696435049,0,0,"up","yes","Dbp","protein_coding","chr1:96175440-96180745:+","gi|7549756|ref|NP_036675.1|",1054,{"v":9e-132,"d":"9.00E-132"},"D site-binding protein isoform 1 [Rattus norvegicus]","gi|88023877|gb|AC136191.5|",2150,0,"Rattus norvegicus BAC CH230-52I17 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P16443",406,{"v":9e-132,"d":"9.00E-132"},"D site-binding protein",".",".",".",".","pfam07716","bZIP_2","Basic region leucine zipper.","GO:0001889|liver development;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007623|circadian rhythm;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:1990837|sequence-specific double-stranded DNA binding;","K09056","DBP; albumin D box-binding protein"]
["ENSRNOG00000020340",6625,426.189153,2077,134.0949825,3.178263236,1.668238619,0,0,"up","yes","Brd8","protein_coding","chr18:26181732-26229884:-","gi|56606080|ref|NP_001008509.1|",4270,0,"bromodomain-containing protein 8 [Rattus norvegicus]","gi|56606079|ref|NM_001008509.1|",3282,0,"Rattus norvegicus bromodomain containing 8 (Brd8), mRNA","Q8R3B7",1523,0,"Bromodomain-containing protein 8","ECU08g1640",64.7,{"v":7e-10,"d":"7.00E-10"},"COG5076","pfam00439","Bromodomain","Bromodomain. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.","GO:0016573|histone acetylation;GO:0043967|histone H4 acetylation;GO:0043968|histone H2A acetylation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0097067|cellular response to thyroid hormone stimulus;","GO:0000812|Swr1 complex;GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005739|mitochondrion;GO:0035267|NuA4 histone acetyltransferase complex;","GO:0003674|molecular_function;GO:0030374|nuclear receptor transcription coactivator activity;GO:0046966|thyroid hormone receptor binding;","K11321","BRD8; bromodomain-containing protein 8"]
["ENSRNOG00000050317",5103,328.2782261,1275,82.31637106,3.988006539,1.995667775,0,0,"up","yes","Uhrf1bp1l","protein_coding","chr7:24181644-24261720:+","gi|157816897|ref|NP_001102223.1|",7599,0,"UHRF1-binding protein 1-like [Rattus norvegicus]","gi|157816896|ref|NM_001108753.1|",7053,0,"Rattus norvegicus UHRF1 binding protein 1-like (Uhrf1bp1l), mRNA","A2RSJ4",2660,0,"UHRF1-binding protein 1-like",".",".",".",".","pfam12624","Chorein_N","N-terminal region of Chorein, a TM vesicle-mediated sorter. Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.",".","GO:0005769|early endosome;GO:0005829|cytosol;","GO:0042803|protein homodimerization activity;GO:0062069|GARP complex binding;",".","."]
["ENSRNOG00000064231",2297,147.7670165,70,4.519330176,32.69666317,5.031071505,0,0,"up","yes","ENSRNOG00000064231","lncRNA","chrX:69859465-69941747:+","gi|667282457|ref|XP_008574777.1|",511,{"v":7e-56,"d":"7.00E-56"},"PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103593548 [Galeopterus variegatus]","gi|1213335|gb|U48828.1|RNU48828",2791,0,"Rattus norvegicus retroviral-like ovarian specific transcript 30-1 mRNA","Q9TTC1",151,{"v":4E-35,"d":"4.00E-35"},"Gag-Pol polyprotein",".",".",".",".","pfam02093","Gag_p30","Gag P30 core shell protein. According to Swiss-Prot annotation this protein is the viral core shell protein. P30 is essential for viral assembly.",".",".",".",".","."]
["ENSRNOG00000060237",9787,629.6019985,4048,261.3464079,2.409070795,1.26847679,0,0,"up","yes","Inhbb","protein_coding","chr13:30530860-30537832:-","gi|29179420|gb|AAH48845.1|",1775,0,"Inhbb protein, partial [Mus musculus]","gi|145966740|ref|NM_008381.3|",3455,0,"Mus musculus inhibin beta-B (Inhbb), mRNA","P17491",688,0,"Inhibin beta B chain",".",".",".",".","pfam00019","TGF_beta","Transforming growth factor beta like domain.","GO:0007283|spermatogenesis;GO:0008584|male gonad development;GO:0008585|female gonad development;GO:0009267|cellular response to starvation;GO:0009611|response to wounding;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0014070|response to organic cyclic compound;GO:0017085|response to insecticide;GO:0021983|pituitary gland development;GO:0032686|negative regulation of hepatocyte growth factor production;GO:0032869|cellular response to insulin stimulus;GO:0032924|activin receptor signaling pathway;GO:0034698|response to gonadotropin;GO:0044320|cellular response to leptin stimulus;GO:0045444|fat cell differentiation;GO:0046676|negative regulation of insulin secretion;GO:0046881|positive regulation of follicle-stimulating hormone secretion;GO:0046882|negative regulation of follicle-stimulating hormone secretion;GO:0048599|oocyte development;GO:0060279|positive regulation of ovulation;GO:0060395|SMAD protein signal transduction;GO:0071277|cellular response to calcium ion;GO:0071320|cellular response to cAMP;GO:0071347|cellular response to interleukin-1;GO:0071397|cellular response to cholesterol;GO:0071407|cellular response to organic cyclic compound;GO:0072520|seminiferous tubule development;GO:0097067|cellular response to thyroid hormone stimulus;GO:1904017|cellular response to Thyroglobulin triiodothyronine;GO:1990636|reproductive senescence;GO:2001235|positive regulation of apoptotic signaling pathway;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0043513|inhibin B complex;GO:0048471|perinuclear region of cytoplasm;GO:0071944|cell periphery;","GO:0005125|cytokine activity;GO:0005179|hormone activity;GO:0008083|growth factor activity;GO:0034711|inhibin binding;GO:0042803|protein homodimerization activity;GO:0044877|protein-containing complex binding;","K22687","INHBB; inhibin beta B chain"]
["ENSRNOG00000019598",9522,612.5544324,3888,251.0165103,2.440295388,1.287055791,0,0,"up","yes","Vegfa","protein_coding","chr9:14955300-14970641:+","gi|160358789|ref|NP_114024.2|",1436,0,"vascular endothelial growth factor A isoform 1 [Rattus norvegicus]","gi|560186573|ref|NM_031836.3|",3546,0,"Rattus norvegicus vascular endothelial growth factor A (Vegfa), transcript variant 1, mRNA","P16612",379,{"v":4e-121,"d":"4.00E-121"},"Vascular endothelial growth factor A",".",".",".",".","pfam00341","PDGF","PDGF/VEGF domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001525|angiogenesis;GO:0001541|ovarian follicle development;GO:0001568|blood vessel development;GO:0001569|branching involved in blood vessel morphogenesis;GO:0001666|response to hypoxia;GO:0001701|in utero embryonic development;GO:0001822|kidney development;GO:0001934|positive regulation of protein phosphorylation;GO:0001938|positive regulation of endothelial cell proliferation;GO:0001944|vasculature development;GO:0001946|lymphangiogenesis;GO:0001974|blood vessel remodeling;GO:0002040|sprouting angiogenesis;GO:0002042|cell migration involved in sprouting angiogenesis;GO:0002052|positive regulation of neuroblast proliferation;GO:0002053|positive regulation of mesenchymal cell proliferation;GO:0002092|positive regulation of receptor internalization;GO:0002575|basophil chemotaxis;GO:0003007|heart morphogenesis;GO:0003151|outflow tract morphogenesis;GO:0003169|coronary vein morphogenesis;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007165|signal transduction;GO:0007399|nervous system development;GO:0007498|mesoderm development;GO:0007565|female pregnancy;GO:0007568|aging;GO:0007595|lactation;GO:0008283|cell proliferation;GO:0008284|positive regulation of cell proliferation;GO:0008360|regulation of cell shape;GO:0009409|response to cold;GO:0009967|positive regulation of signal transduction;GO:0010595|positive regulation of endothelial cell migration;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010719|negative regulation of epithelial to mesenchymal transition;GO:0010749|regulation of nitric oxide mediated signal transduction;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0016477|cell migration;GO:0022408|negative regulation of cell-cell adhesion;GO:0030154|cell differentiation;GO:0030224|monocyte differentiation;GO:0030225|macrophage differentiation;GO:0030324|lung development;GO:0030335|positive regulation of cell migration;GO:0030855|epithelial cell differentiation;GO:0031077|post-embryonic camera-type eye development;GO:0031334|positive regulation of protein complex assembly;GO:0031954|positive regulation of protein autophosphorylation;GO:0032147|activation of protein kinase activity;GO:0032355|response to estradiol;GO:0032570|response to progesterone;GO:0032793|positive regulation of CREB transcription factor activity;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0033189|response to vitamin A;GO:0035148|tube formation;GO:0035767|endothelial cell chemotaxis;GO:0035924|cellular response to vascular endothelial growth factor stimulus;GO:0036303|lymph vessel morphogenesis;GO:0036324|vascular endothelial growth factor receptor-2 signaling pathway;GO:0038033|positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway;GO:0038084|vascular endothelial growth factor signaling pathway;GO:0038089|positive regulation of cell migration by vascular endothelial growth factor signaling pathway;GO:0038091|positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway;GO:0038190|VEGF-activated neuropilin signaling pathway;GO:0040008|regulation of growth;GO:0042060|wound healing;GO:0042088|T-helper 1 type immune response;GO:0042327|positive regulation of phosphorylation;GO:0042462|eye photoreceptor cell development;GO:0043066|negative regulation of apoptotic process;GO:0043069|negative regulation of programmed cell death;GO:0043117|positive regulation of vascular permeability;GO:0043129|surfactant homeostasis;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043406|positive regulation of MAP kinase activity;GO:0043410|positive regulation of MAPK cascade;GO:0043524|negative regulation of neuron apoptotic process;GO:0043536|positive regulation of blood vessel endothelial cell migration;GO:0043542|endothelial cell migration;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0045599|negative regulation of fat cell differentiation;GO:0045601|regulation of endothelial cell differentiation;GO:0045669|positive regulation of osteoblast differentiation;GO:0045766|positive regulation of angiogenesis;GO:0045779|negative regulation of bone resorption;GO:0045785|positive regulation of cell adhesion;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048010|vascular endothelial growth factor receptor signaling pathway;GO:0048255|mRNA stabilization;GO:0048286|lung alveolus development;GO:0048469|cell maturation;GO:0048514|blood vessel morphogenesis;GO:0048593|camera-type eye morphogenesis;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0048666|neuron development;GO:0048754|branching morphogenesis of an epithelial tube;GO:0048842|positive regulation of axon extension involved in axon guidance;GO:0048844|artery morphogenesis;GO:0048873|homeostasis of number of cells within a tissue;GO:0050679|positive regulation of epithelial cell proliferation;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050918|positive chemotaxis;GO:0050927|positive regulation of positive chemotaxis;GO:0050930|induction of positive chemotaxis;GO:0051272|positive regulation of cellular component movement;GO:0051593|response to folic acid;GO:0051781|positive regulation of cell division;GO:0051894|positive regulation of focal adhesion assembly;GO:0051897|positive regulation of protein kinase B signaling;GO:0055013|cardiac muscle cell development;GO:0060319|primitive erythrocyte differentiation;GO:0060326|cell chemotaxis;GO:0060346|bone trabecula formation;GO:0060426|lung vasculature development;GO:0060749|mammary gland alveolus development;GO:0060754|positive regulation of mast cell chemotaxis;GO:0060948|cardiac vascular smooth muscle cell development;GO:0060978|angiogenesis involved in coronary vascular morphogenesis;GO:0060982|coronary artery morphogenesis;GO:0061042|vascular wound healing;GO:0061419|positive regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0061430|bone trabecula morphogenesis;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070482|response to oxygen levels;GO:0071456|cellular response to hypoxia;GO:0071466|cellular response to xenobiotic stimulus;GO:0071542|dopaminergic neuron differentiation;GO:0071548|response to dexamethasone;GO:0071549|cellular response to dexamethasone stimulus;GO:0071679|commissural neuron axon guidance;GO:0090037|positive regulation of protein kinase C signaling;GO:0090050|positive regulation of cell migration involved in sprouting angiogenesis;GO:0090190|positive regulation of branching involved in ureteric bud morphogenesis;GO:0090259|regulation of retinal ganglion cell axon guidance;GO:0097475|motor neuron migration;GO:0097533|cellular stress response to acid chemical;GO:0120162|positive regulation of cold-induced thermogenesis;GO:1900086|positive regulation of peptidyl-tyrosine autophosphorylation;GO:1900745|positive regulation of p38MAPK cascade;GO:1901165|positive regulation of trophoblast cell migration;GO:1901215|negative regulation of neuron death;GO:1901492|positive regulation of lymphangiogenesis;GO:1901532|regulation of hematopoietic progenitor cell differentiation;GO:1901727|positive regulation of histone deacetylase activity;GO:1902336|positive regulation of retinal ganglion cell axon guidance;GO:1902966|positive regulation of protein localization to early endosome;GO:1903141|negative regulation of establishment of endothelial barrier;GO:1903392|negative regulation of adherens junction organization;GO:1903572|positive regulation of protein kinase D signaling;GO:1903589|positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:1903672|positive regulation of sprouting angiogenesis;GO:1905278|positive regulation of epithelial tube formation;GO:1905604|negative regulation of maintenance of permeability of blood-brain barrier;GO:2000048|negative regulation of cell-cell adhesion mediated by cadherin;GO:2000573|positive regulation of DNA biosynthetic process;GO:2001237|negative regulation of extrinsic apoptotic signaling pathway;","GO:0005576|extracellular region;GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005912|adherens junction;GO:0009986|cell surface;GO:0016020|membrane;GO:0030141|secretory granule;GO:0031982|vesicle;","GO:0001968|fibronectin binding;GO:0005102|signaling receptor binding;GO:0005125|cytokine activity;GO:0005161|platelet-derived growth factor receptor binding;GO:0005172|vascular endothelial growth factor receptor binding;GO:0008083|growth factor activity;GO:0008201|heparin binding;GO:0019838|growth factor binding;GO:0038191|neuropilin binding;GO:0042056|chemoattractant activity;GO:0042802|identical protein binding;GO:0043183|vascular endothelial growth factor receptor 1 binding;GO:0043184|vascular endothelial growth factor receptor 2 binding;GO:0048018|receptor ligand activity;GO:0050840|extracellular matrix binding;","K05448","VEGFA; vascular endothelial growth factor A"]
["ENSRNOG00000019412",3062,196.9798017,352,22.7257746,8.667682629,3.11564633,0,0,"up","yes","Rhbg","protein_coding","chr2:173704562-173717321:-","gi|34013522|ref|NP_898877.1|",1531,0,"ammonium transporter Rh type B precursor [Rattus norvegicus]","gi|51259432|gb|BC079365.1|",1238,0,"Rattus norvegicus Rh family, B glycoprotein, mRNA (cDNA clone MGC:94848 IMAGE:7109321), complete cds","Q68FT6",593,0,"Ammonium transporter Rh type B",".",".",".",".","pfam00909","Ammonium_transp","Ammonium Transporter Family.","GO:0008150|biological_process;GO:0015696|ammonium transport;GO:0070634|transepithelial ammonium transport;GO:0072488|ammonium transmembrane transport;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0014731|spectrin-associated cytoskeleton;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0030659|cytoplasmic vesicle membrane;GO:0046658|anchored component of plasma membrane;","GO:0003674|molecular_function;GO:0008519|ammonium transmembrane transporter activity;GO:0030506|ankyrin binding;","K06580","SLC42A, RHAG, RHBG, RHCG, CD241; ammonium transporter Rh"]
["ENSRNOG00000056457",2662,171.2476264,207,13.36430495,12.81380716,3.679627279,0,0,"up","yes","Gpd1","protein_coding","chr7:130844138-130851529:+","gi|57527919|ref|NP_071551.2|",1666,0,"glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic [Rattus norvegicus]","gi|564400292|ref|XM_006257376.1|",1859,0,"PREDICTED: Rattus norvegicus glycerol-3-phosphate dehydrogenase 1 (soluble) (Gpd1), transcript variant X1, mRNA","O35077",646,0,"Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic","SPBC215.05",326,{"v":2E-99,"d":"2.00E-99"},"COG0240","pfam01210","NAD_Gly3P_dh_N","NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus. NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyses the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain.","GO:0005975|carbohydrate metabolic process;GO:0006072|glycerol-3-phosphate metabolic process;GO:0006094|gluconeogenesis;GO:0006116|NADH oxidation;GO:0006127|glycerophosphate shuttle;GO:0006734|NADH metabolic process;GO:0045821|positive regulation of glycolytic process;GO:0046168|glycerol-3-phosphate catabolic process;GO:0046486|glycerolipid metabolic process;GO:0071320|cellular response to cAMP;GO:0071356|cellular response to tumor necrosis factor;","GO:0005829|cytosol;GO:0009331|glycerol-3-phosphate dehydrogenase complex;","GO:0004367|glycerol-3-phosphate dehydrogenase [NAD+] activity;GO:0004368|glycerol-3-phosphate dehydrogenase (quinone) activity;GO:0042803|protein homodimerization activity;GO:0051287|NAD binding;","K00006","GPD1; glycerol-3-phosphate dehydrogenase (NAD+) [EC:1.1.1.8]"]
["ENSRNOG00000045605",4659,299.7155115,1065,68.75838053,4.358966997,2.123986281,0,0,"up","yes","Uxs1","protein_coding","chr9:653659-756334:+","gi|359751462|ref|NP_001240804.1|",2062,0,"UDP-glucuronic acid decarboxylase 1 isoform 1 [Homo sapiens]","gi|672063916|ref|XM_008766751.1|",1932,0,"PREDICTED: Rattus norvegicus UDP-glucuronate decarboxylase 1 (Uxs1), transcript variant X6, mRNA","Q8NBZ7",782,0,"UDP-glucuronic acid decarboxylase 1","alr0657",436,{"v":4e-144,"d":"4.00E-144"},"COG0451","pfam01370","Epimerase","NAD dependent epimerase/dehydratase family. This family of proteins utilize NAD as a cofactor. The proteins in this family use nucleotide-sugar substrates for a variety of chemical reactions.","GO:0033320|UDP-D-xylose biosynthetic process;GO:0042732|D-xylose metabolic process;","GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;GO:0032580|Golgi cisterna membrane;GO:1902494|catalytic complex;","GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0048040|UDP-glucuronate decarboxylase activity;GO:0070403|NAD+ binding;","K08678","UXS1, uxs; UDP-glucuronate decarboxylase [EC:4.1.1.35]"]
["ENSRNOG00000067242",4457,286.720763,977,63.07693688,4.545572077,2.184461874,0,0,"up","yes","ENSRNOG00000067242","protein_coding","chrX:111691855-111700281:-","gi|148676020|gb|EDL07967.1|",1103,{"v":4e-135,"d":"4.00E-135"},"mCG1029965 [Mus musculus]","gi|46240867|gb|AC107531.8|",2301,0,"Rattus norvegicus 1 BAC CH230-158N3 (Children's Hospital Oakland Research Institute) complete sequence","P31789",206,{"v":3e-55,"d":"3.00E-55"},"Envelope glycoprotein",".",".",".",".","pfam00517","GP41","Retroviral envelope protein. This family includes envelope protein from a variety of retroviruses. It includes the GP41 subunit of the envelope protein complex from human and simian immunodeficiency viruses (HIV and SIV) which mediate membrane fusion during viral entry. The family also includes bovine immunodeficiency virus, feline immunodeficiency virus and Equine infectious anaemia (EIAV). The family also includes the Gp36 protein from mouse mammary tumor virus (MMTV) and human endogenous retroviruses (HERVs).",".",".",".",".","."]
["ENSRNOG00000016552",4381,281.8316497,943,60.88183365,4.629158367,2.210749919,0,0,"up","yes","Hmgcs1","protein_coding","chr2:51649497-51667100:+","gi|149059420|gb|EDM10427.1|",2970,0,"rCG44679, isoform CRA_b [Rattus norvegicus]","gi|8393537|ref|NM_017268.1|",3198,0,"Rattus norvegicus 3-hydroxy-3-methylglutaryl-CoA synthase 1 (Hmgcs1), mRNA","P17425",1087,0,"Hydroxymethylglutaryl-CoA synthase, cytoplasmic","SPAC4F8.14c",439,{"v":5e-141,"d":"5.00E-141"},"COG3425","pfam08540","HMG_CoA_synt_C","Hydroxymethylglutaryl-coenzyme A synthase C terminal.","GO:0001889|liver development;GO:0006084|acetyl-CoA metabolic process;GO:0006695|cholesterol biosynthetic process;GO:0007420|brain development;GO:0008584|male gonad development;GO:0009410|response to xenobiotic stimulus;GO:0009645|response to low light intensity stimulus;GO:0009725|response to hormone;GO:0010033|response to organic substance;GO:0010142|farnesyl diphosphate biosynthetic process, mevalonate pathway;GO:0014070|response to organic cyclic compound;GO:0014074|response to purine-containing compound;GO:0033197|response to vitamin E;GO:0034698|response to gonadotropin;GO:0046690|response to tellurium ion;GO:0070723|response to cholesterol;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0071397|cellular response to cholesterol;GO:0071404|cellular response to low-density lipoprotein particle stimulus;GO:0071407|cellular response to organic cyclic compound;","GO:0005829|cytosol;","GO:0004421|hydroxymethylglutaryl-CoA synthase activity;GO:0016853|isomerase activity;GO:0036094|small molecule binding;GO:0042803|protein homodimerization activity;GO:0043177|organic acid binding;","K01641","HMGCS; hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10]"]
["ENSRNOG00000014117",4706,302.7390421,1109,71.59910236,4.228251921,2.080061336,0,0,"up","yes","Hmox1","protein_coding","chr19:13467244-13474079:+","gi|6981032|ref|NP_036712.1|",1496,0,"heme oxygenase 1 [Rattus norvegicus]","gi|61098187|ref|NM_012580.2|",1494,0,"Rattus norvegicus heme oxygenase 1 (Hmox1), mRNA","P06762",559,0,"Heme oxygenase 1","sll1184",205,{"v":6e-61,"d":"6.00E-61"},"COG5398","pfam01126","Heme_oxygenase","Heme oxygenase.","GO:0001525|angiogenesis;GO:0001666|response to hypoxia;GO:0002246|wound healing involved in inflammatory response;GO:0006644|phospholipid metabolic process;GO:0006788|heme oxidation;GO:0006879|cellular iron ion homeostasis;GO:0006979|response to oxidative stress;GO:0007264|small GTPase mediated signal transduction;GO:0008217|regulation of blood pressure;GO:0008219|cell death;GO:0008285|negative regulation of cell proliferation;GO:0008630|intrinsic apoptotic signaling pathway in response to DNA damage;GO:0009410|response to xenobiotic stimulus;GO:0010656|negative regulation of muscle cell apoptotic process;GO:0016239|positive regulation of macroautophagy;GO:0016242|negative regulation of macroautophagy;GO:0031670|cellular response to nutrient;GO:0032764|negative regulation of mast cell cytokine production;GO:0034101|erythrocyte homeostasis;GO:0034395|regulation of transcription from RNA polymerase II promoter in response to iron;GO:0034605|cellular response to heat;GO:0035094|response to nicotine;GO:0035556|intracellular signal transduction;GO:0042167|heme catabolic process;GO:0042168|heme metabolic process;GO:0042542|response to hydrogen peroxide;GO:0043065|positive regulation of apoptotic process;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043305|negative regulation of mast cell degranulation;GO:0043392|negative regulation of DNA binding;GO:0043433|negative regulation of DNA-binding transcription factor activity;GO:0043524|negative regulation of neuron apoptotic process;GO:0043619|regulation of transcription from RNA polymerase II promoter in response to oxidative stress;GO:0043627|response to estrogen;GO:0043922|negative regulation by host of viral transcription;GO:0045766|positive regulation of angiogenesis;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0048662|negative regulation of smooth muscle cell proliferation;GO:0051090|regulation of DNA-binding transcription factor activity;GO:0055072|iron ion homeostasis;GO:0071243|cellular response to arsenic-containing substance;GO:0071276|cellular response to cadmium ion;GO:0071456|cellular response to hypoxia;GO:0072719|cellular response to cisplatin;GO:0090050|positive regulation of cell migration involved in sprouting angiogenesis;GO:0097421|liver regeneration;GO:1902042|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1903589|positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:1903901|negative regulation of viral life cycle;GO:1904036|negative regulation of epithelial cell apoptotic process;GO:1904706|negative regulation of vascular smooth muscle cell proliferation;","GO:0005634|nucleus;GO:0005730|nucleolus;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005901|caveola;GO:0048471|perinuclear region of cytoplasm;","GO:0004392|heme oxygenase (decyclizing) activity;GO:0004630|phospholipase D activity;GO:0005198|structural molecule activity;GO:0005515|protein binding;GO:0019899|enzyme binding;GO:0020037|heme binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0046872|metal ion binding;","K00510","HMOX1; heme oxygenase 1 [EC:1.14.14.18]"]
["ENSRNOG00000013552",2930,188.4881839,319,20.59523323,9.152029587,3.194091716,0,0,"up","yes","Scd","protein_coding","chr1:243269747-243282562:-","gi|148747464|ref|NP_631931.2|",1815,0,"acyl-CoA desaturase 1 [Rattus norvegicus]","gi|672040335|ref|XM_006231433.2|",4690,0,"PREDICTED: Rattus norvegicus stearoyl-Coenzyme A desaturase 1 (Scd1), transcript variant X1, mRNA","P07308",703,0,"Acyl-CoA desaturase 1","SPCC1281.06c_1",208,{"v":2e-57,"d":"2.00E-57"},"COG1398","pfam00487","FA_desaturase","Fatty acid desaturase.","GO:0006633|fatty acid biosynthetic process;GO:0006636|unsaturated fatty acid biosynthetic process;GO:0006641|triglyceride metabolic process;GO:0008610|lipid biosynthetic process;GO:0009617|response to bacterium;GO:0033561|regulation of water loss via skin;GO:0034434|sterol esterification;GO:0034435|cholesterol esterification;GO:0048733|sebaceous gland development;GO:0050830|defense response to Gram-positive bacterium;GO:0050872|white fat cell differentiation;GO:0050873|brown fat cell differentiation;GO:0055088|lipid homeostasis;GO:0070542|response to fatty acid;GO:0120162|positive regulation of cold-induced thermogenesis;GO:1903699|tarsal gland development;GO:1903966|monounsaturated fatty acid biosynthetic process;","GO:0005730|nucleolus;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0030176|integral component of endoplasmic reticulum membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0004768|stearoyl-CoA 9-desaturase activity;GO:0005506|iron ion binding;GO:0016491|oxidoreductase activity;GO:0032896|palmitoyl-CoA 9-desaturase activity;GO:0046872|metal ion binding;","K00507","SCD, desC; stearoyl-CoA desaturase (Delta-9 desaturase) [EC:1.14.19.1]"]
["ENSRNOG00000014828",4190,269.544536,866,55.91057046,4.820994201,2.269330695,0,0,"up","yes","Avpi1","protein_coding","chr1:240930236-240936154:-","gi|564333748|ref|XP_006231445.1|",907,{"v":2E-118,"d":"2.00E-118"},"PREDICTED: arginine vasopressin-induced protein 1 isoform X1 [Rattus norvegicus]","gi|404312674|ref|NM_134373.2|",1084,0,"Rattus norvegicus arginine vasopressin-induced 1 (Avpi1), mRNA","Q8VDA6",248,{"v":5E-80,"d":"5.00E-80"},"Arginine vasopressin-induced protein 1",".",".",".",".","pfam15063","TC1","Thyroid cancer protein 1. Thyroid cancer protein 1 (TC1) is thought to decrease in apoptosis and increase cell proliferation. It is found to be expressed in thyroid papillary carcinoma. This suggests its importance in thyroid cancer. The molecular mechanism of TC1, involves up-regulating cell signalling through ERK-1/2 signalling pathway and it positively regulates transition between the G1 and S phase in the cell cycle. It is thought to positively regulate Wnt/beta-catenin signalling pathway by interacting with its repressor. In humans, it is located in the chromosomal position, C8orf4. This family of proteins is found in eukaryotes and contains a conserved NIF sequence motif.","GO:0008150|biological_process;GO:0043410|positive regulation of MAPK cascade;","GO:0005575|cellular_component;","GO:0003674|molecular_function;",".","."]
["ENSRNOG00000014980",3991,256.7427788,820,52.94072492,4.849627186,2.277873845,0,0,"up","yes","Mob4","protein_coding","chr9:56617368-56641329:+","gi|19424180|ref|NP_598212.1|",1208,{"v":1e-157,"d":"1.00E-157"},"MOB-like protein phocein [Rattus norvegicus]","gi|55715642|gb|BC085708.1|",2473,0,"Rattus norvegicus MOB1, Mps One Binder kinase activator-like 3 (yeast), mRNA (cDNA clone MGC:93220 IMAGE:7193103), complete cds","Q9QYW3",469,{"v":4E-159,"d":"4.00E-159"},"MOB-like protein phocein",".",".",".",".","pfam03637","Mob1_phocein","Mob1/phocein family. Mob1 is an essential Saccharomyces cerevisiae protein, identified from a two-hybrid screen, that binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Mob1 contains no known structural motifs; however MOB1 is a member of a conserved gene family and shares sequence similarity with a nonessential yeast gene, MOB2. Mob1 is a phosphoprotein in vivo and a substrate for the Mps1p kinase in vitro. Conditional alleles of MOB1 cause a late nuclear division arrest at restrictive temperature. This family also includes phocein, a rat protein that by yeast two hybrid interacts with striatin.","GO:0006900|vesicle budding from membrane;","GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0016020|membrane;GO:0032580|Golgi cisterna membrane;GO:0043025|neuronal cell body;GO:0043197|dendritic spine;GO:0048471|perinuclear region of cytoplasm;","GO:0005515|protein binding;GO:0019900|kinase binding;GO:0046872|metal ion binding;",".","."]
["ENSRNOG00000068973",2998,192.8626537,388,25.05000155,7.699107456,2.944691206,0,0,"up","yes","ENSRNOG00000068973","protein_coding","chr1:15046564-15050125:-","gi|45478088|gb|AAS66215.1|",680,{"v":1e-77,"d":"1.00E-77"},"LRRG00124 [Rattus norvegicus]","gi|34555688|gb|AY343914.1|",520,0,"Rattus norvegicus genomic sequence","P11369",230,{"v":8e-69,"d":"8.00E-69"},"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam12488","DUF3704","Protein of unknown function (DUF3704). This domain family is found in eukaryotes, and is approximately 30 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000007607",3961,254.8128657,811,52.35966818,4.866586717,2.282910262,0,0,"up","yes","Nr4a1","protein_coding","chr7:132374840-132389297:+","gi|399498497|ref|NP_077364.2|",2573,0,"nuclear receptor subfamily 4 group A member 1 [Rattus norvegicus]","gi|399498496|ref|NM_024388.2|",2488,0,"Rattus norvegicus nuclear receptor subfamily 4, group A, member 1 (Nr4a1), mRNA","P22829",995,0,"Nuclear receptor subfamily 4 group A member 1",".",".",".",".","pfam00105","zf-C4","Zinc finger, C4 type (two domains). In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.","GO:0001938|positive regulation of endothelial cell proliferation;GO:0001975|response to amphetamine;GO:0002042|cell migration involved in sprouting angiogenesis;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006915|apoptotic process;GO:0014860|neurotransmitter secretion involved in regulation of skeletal muscle contraction;GO:0030522|intracellular receptor signaling pathway;GO:0032496|response to lipopolysaccharide;GO:0035767|endothelial cell chemotaxis;GO:0035914|skeletal muscle cell differentiation;GO:0035924|cellular response to vascular endothelial growth factor stimulus;GO:0043065|positive regulation of apoptotic process;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0045444|fat cell differentiation;GO:0045786|negative regulation of cell cycle;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051602|response to electrical stimulus;GO:0061469|regulation of type B pancreatic cell proliferation;GO:0071310|cellular response to organic substance;GO:0071376|cellular response to corticotropin-releasing hormone stimulus;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;GO:0031965|nuclear membrane;GO:0098793|presynapse;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0004879|nuclear receptor activity;GO:0005515|protein binding;GO:0008270|zinc ion binding;GO:0035259|glucocorticoid receptor binding;GO:0042802|identical protein binding;GO:0043565|sequence-specific DNA binding;GO:0046982|protein heterodimerization activity;GO:1990837|sequence-specific double-stranded DNA binding;","K04465","NR4A1, HMR; nuclear receptor subfamily 4 group A member 1"]
["ENSRNOG00000007060",7310,470.2555031,2669,172.3156034,2.729036105,1.448391481,0,0,"up","yes","Plin2","protein_coding","chr5:101154411-101242319:-","gi|564351582|ref|XP_006238422.1|",2092,0,"PREDICTED: perilipin-2 isoform X1 [Rattus norvegicus]","gi|672052845|ref|XM_006238360.2|",1808,0,"PREDICTED: Rattus norvegicus perilipin 2 (Plin2), transcript variant X1, mRNA","P43883",701,0,"Perilipin-2",".",".",".",".","pfam03036","Perilipin","Perilipin family. The perilipin family includes lipid droplet-associated protein (perilipin) and adipose differentiation-related protein (adipophilin).","GO:0009410|response to xenobiotic stimulus;GO:0010890|positive regulation of sequestering of triglyceride;GO:0014070|response to organic cyclic compound;GO:0015909|long-chain fatty acid transport;GO:0019915|lipid storage;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005811|lipid droplet;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0003674|molecular_function;","K17284","PLIN2, ADRP; perilipin-2"]
["ENSRNOG00000016977",2173,139.7900422,109,7.037242702,19.86432017,4.312107515,0,0,"up","yes","Calb2","protein_coding","chr19:38114424-38141438:-","gi|672084703|ref|XP_008770688.1|",1282,{"v":4e-171,"d":"4.00E-171"},"PREDICTED: calretinin isoform X1 [Rattus norvegicus]","gi|672084702|ref|XM_008772466.1|",1304,0,"PREDICTED: Rattus norvegicus calbindin 2 (Calb2), transcript variant X1, mRNA","P47728",494,{"v":3e-172,"d":"3.00E-172"},"Calretinin",".",".",".",".","pfam13499","EF-hand_7","EF-hand domain pair.","GO:0008150|biological_process;GO:0051480|regulation of cytosolic calcium ion concentration;GO:0099509|regulation of presynaptic cytosolic calcium ion concentration;GO:1900271|regulation of long-term synaptic potentiation;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005921|gap junction;GO:0030425|dendrite;GO:0032420|stereocilium;GO:0032437|cuticular plate;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0045202|synapse;GO:0097060|synaptic membrane;GO:0098688|parallel fiber to Purkinje cell synapse;GO:0099096|vestibular calyx terminal;","GO:0005509|calcium ion binding;GO:0099534|calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration;","K23908","CALB2; calretinin"]
["ENSRNOG00000017283",4049,260.4739442,890,57.46005509,4.533130777,2.180507782,0,0,"up","yes","Kcnt1","protein_coding","chr3:8682113-8736667:+","gi|564339775|ref|XP_006233769.1|",6032,0,"PREDICTED: potassium channel subfamily T member 1 isoform X11 [Rattus norvegicus]","gi|672044814|ref|XM_006233707.2|",4683,0,"PREDICTED: Rattus norvegicus potassium channel, subfamily T, member 1 (Kcnt1), transcript variant X11, mRNA","Q9Z258",2244,0,"Potassium channel subfamily T member 1",".",".",".",".","pfam03493","BK_channel_a","Calcium-activated BK potassium channel alpha subunit.","GO:0006813|potassium ion transport;GO:0071805|potassium ion transmembrane transport;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0005228|intracellular sodium activated potassium channel activity;GO:0005267|potassium channel activity;GO:0015271|outward rectifier potassium channel activity;","K04946","KCNT1, KNA1.1; potassium channel subfamily T member 1"]
["ENSRNOG00000003520",8061,518.5676622,3275,211.4400904,2.45255127,1.294283296,0,0,"up","yes","Prdx2","protein_coding","chr19:23180930-23186194:-","gi|564394891|ref|XP_006255306.1|",1054,{"v":1E-141,"d":"1.00E-141"},"PREDICTED: peroxiredoxin-2 isoform X1 [Rattus norvegicus]","gi|564394890|ref|XM_006255244.1|",1018,0,"PREDICTED: Rattus norvegicus peroxiredoxin 2 (Prdx2), transcript variant X1, mRNA","P35704",408,{"v":3e-142,"d":"3.00E-142"},"Peroxiredoxin-2","SPCC576.03c",270,{"v":1e-88,"d":"1.00E-88"},"COG0450","pfam00578","AhpC-TSA","AhpC/TSA family. This family contains proteins related to alkyl hydroperoxide reductase (AhpC) and thiol specific antioxidant (TSA).","GO:0002357|defense response to tumor cell;GO:0002536|respiratory burst involved in inflammatory response;GO:0006979|response to oxidative stress;GO:0010310|regulation of hydrogen peroxide metabolic process;GO:0019430|removal of superoxide radicals;GO:0030194|positive regulation of blood coagulation;GO:0031665|negative regulation of lipopolysaccharide-mediated signaling pathway;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0032496|response to lipopolysaccharide;GO:0033554|cellular response to stress;GO:0034599|cellular response to oxidative stress;GO:0042098|T cell proliferation;GO:0042743|hydrogen peroxide metabolic process;GO:0042744|hydrogen peroxide catabolic process;GO:0042981|regulation of apoptotic process;GO:0043410|positive regulation of MAPK cascade;GO:0043524|negative regulation of neuron apoptotic process;GO:0045321|leukocyte activation;GO:0045454|cell redox homeostasis;GO:0045581|negative regulation of T cell differentiation;GO:0048538|thymus development;GO:0048872|homeostasis of number of cells;GO:2001237|negative regulation of extrinsic apoptotic signaling pathway;GO:2001240|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;","GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0003674|molecular_function;GO:0008379|thioredoxin peroxidase activity;GO:0016209|antioxidant activity;","K03386","PRDX2_4, ahpC; peroxiredoxin 2/4 [EC:1.11.1.24]"]
["ENSRNOG00000007743",6961,447.8041802,2631,169.8622528,2.636278355,1.398502707,0,0,"up","yes","Mgst1","protein_coding","chr4:171029630-171044892:+","gi|568942484|ref|XP_006506481.1|",895,{"v":4e-117,"d":"4.00E-117"},"PREDICTED: microsomal glutathione S-transferase 1 isoform X1 [Mus musculus]","gi|298911493|emb|FQ219581.1|",861,0,"Rattus norvegicus TL0ABA44YF24 mRNA sequence","P08011",292,{"v":2e-97,"d":"2.00E-97"},"Microsomal glutathione S-transferase 1",".",".",".",".","pfam01124","MAPEG","MAPEG family. This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolizm). It includes proteins such as Prostaglandin E synthase. This enzyme catalyses the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.","GO:0006749|glutathione metabolic process;GO:0009410|response to xenobiotic stimulus;GO:0010243|response to organonitrogen compound;GO:0032496|response to lipopolysaccharide;GO:0033327|Leydig cell differentiation;GO:0034635|glutathione transport;GO:0071449|cellular response to lipid hydroperoxide;GO:0098869|cellular oxidant detoxification;","GO:0005634|nucleus;GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0005778|peroxisomal membrane;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0045177|apical part of cell;","GO:0004364|glutathione transferase activity;GO:0004602|glutathione peroxidase activity;GO:0042802|identical protein binding;GO:0043295|glutathione binding;","K00799","GST, gst; glutathione S-transferase [EC:2.5.1.18]"]
["ENSRNOG00000052498",5053,325.0617041,1519,98.06946482,3.31460669,1.728837691,0,0,"up","yes","Grb14","protein_coding","chr3:49568210-49683889:-","gi|149022123|gb|EDL79017.1|",2843,0,"rCG26210 [Rattus norvegicus]","gi|13928857|ref|NM_031623.1|",1734,0,"Rattus norvegicus growth factor receptor bound protein 14 (Grb14), mRNA","O88900",1096,0,"Growth factor receptor-bound protein 14",".",".",".",".","pfam08947","BPS","BPS (Between PH and SH2). The BPS (Between PH and SH2) domain, comprised of 2 beta strands and a C-terminal helix, is an approximately 45 residue region found in the adaptor proteins Grb7/10/14 that mediates inhibition of the tyrosine kinase domain of the insulin receptor by binding of the N-terminal portion of the BPS domain to the substrate peptide groove of the kinase, acting as a pseudosubstrate inhibitor.","GO:0007165|signal transduction;GO:0008286|insulin receptor signaling pathway;GO:0032869|cellular response to insulin stimulus;GO:0035556|intracellular signal transduction;GO:0046627|negative regulation of insulin receptor signaling pathway;GO:1904145|negative regulation of meiotic cell cycle process involved in oocyte maturation;","GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0010008|endosome membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0005515|protein binding;GO:0030674|protein binding, bridging;GO:0030971|receptor tyrosine kinase binding;GO:0051219|phosphoprotein binding;","K23696","GRB14; growth factor receptor-bound protein 14"]
["ENSRNOG00000062568",3498,225.0278728,731,47.19471941,4.768073115,2.253406359,0,0,"up","yes","ENSRNOG00000062568","protein_coding","chr8:5386797-5392957:+","gi|852807785|ref|XP_012892095.1|",457,{"v":5e-67,"d":"5.00E-67"},"PREDICTED: uncharacterized protein LOC106001575 [Dipodomys ordii]","gi|345091104|gb|AC244812.3|",764,0,"Rattus norvegicus Y Chr BAC RNAEX-259L10 (Amplicon Express Rat SHR-Akr BAC library) complete sequence","P12894",187,{"v":2e-65,"d":"2.00E-65"},"Intracisternal A-particle Pol-related polyprotein (Fragment)",".",".",".",".","pfam02994","Transposase_22","L1 transposable element.",".",".",".",".","."]
["ENSRNOG00000003687",5012,322.4241562,1522,98.2631504,3.28123162,1.714237436,0,0,"up","yes","Rgs2","protein_coding","chr13:55798829-55802385:-","gi|16758194|ref|NP_445905.1|",1018,{"v":6e-133,"d":"6.00E-133"},"regulator of G-protein signaling 2 [Rattus norvegicus]","gi|298897112|emb|FQ224353.1|",1632,0,"Rattus norvegicus TL0ACA69YI09 mRNA sequence","Q9JHX0",396,{"v":2e-134,"d":"2.00E-134"},"Regulator of G-protein signaling 2",".",".",".",".","pfam00615","RGS","Regulator of G protein signaling domain. RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.","GO:0001975|response to amphetamine;GO:0007283|spermatogenesis;GO:0007420|brain development;GO:0008277|regulation of G protein-coupled receptor signaling pathway;GO:0010519|negative regulation of phospholipase activity;GO:0010614|negative regulation of cardiac muscle hypertrophy;GO:0010976|positive regulation of neuron projection development;GO:0017148|negative regulation of translation;GO:0030728|ovulation;GO:0043407|negative regulation of MAP kinase activity;GO:0045471|response to ethanol;GO:0045744|negative regulation of G protein-coupled receptor signaling pathway;GO:0050873|brown fat cell differentiation;GO:0055119|relaxation of cardiac muscle;GO:0060087|relaxation of vascular smooth muscle;GO:0060135|maternal process involved in female pregnancy;GO:0060452|positive regulation of cardiac muscle contraction;GO:0061052|negative regulation of cell growth involved in cardiac muscle cell development;GO:0140194|negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process;GO:1900924|negative regulation of glycine import across plasma membrane;","GO:0005634|nucleus;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0009898|cytoplasmic side of plasma membrane;GO:0043005|neuron projection;","GO:0001965|G-protein alpha-subunit binding;GO:0005096|GTPase activator activity;GO:0010855|adenylate cyclase inhibitor activity;GO:0048487|beta-tubulin binding;","K18154","RGS2; regulator of G-protein signaling 2"]
["ENSRNOG00000020361",7036,452.6289631,2737,176.7058099,2.561483198,1.356979429,0,0,"up","yes","Ip6k2","protein_coding","chr8:109484310-109510166:+","gi|961743782|ref|XP_014932518.1|",2223,0,"PREDICTED: inositol hexakisphosphate kinase 2 isoform X1 [Acinonyx jubatus]","gi|672063133|ref|XM_008766564.1|",1550,0,"PREDICTED: Rattus norvegicus inositol hexakisphosphate kinase 2 (Ip6k2), transcript variant X1, mRNA","Q9R0U1",843,0,"Inositol hexakisphosphate kinase 2",".",".",".",".","pfam03770","IPK","Inositol polyphosphate kinase. ArgRIII has has been demonstrated to be an inositol polyphosphate kinase.","GO:0006817|phosphate ion transport;GO:0016310|phosphorylation;GO:0030308|negative regulation of cell growth;GO:0032958|inositol phosphate biosynthetic process;GO:0043065|positive regulation of apoptotic process;GO:0043647|inositol phosphate metabolic process;GO:0046854|phosphatidylinositol phosphorylation;GO:1905396|cellular response to flavonoid;","GO:0001650|fibrillar center;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0030054|cell junction;","GO:0000828|inositol hexakisphosphate kinase activity;GO:0000832|inositol hexakisphosphate 5-kinase activity;GO:0005524|ATP binding;GO:0016301|kinase activity;GO:0097243|flavonoid binding;","K07756","IP6K, IHPK; inositol-hexakisphosphate 5-kinase [EC:2.7.4.21]"]
["ENSRNOG00000042848",7224,464.7230854,2893,186.77746,2.488111175,1.31505095,0,0,"up","yes","Jam2","protein_coding","chr11:23831106-23880063:+","gi|77404265|ref|NP_001029176.1|",1273,{"v":3e-159,"d":"3.00E-159"},"junctional adhesion molecule B precursor [Rattus norvegicus]","gi|77404264|ref|NM_001034004.1|",3907,0,"Rattus norvegicus junctional adhesion molecule 2 (Jam2), mRNA","Q9JI59",473,{"v":9E-153,"d":"9.00E-153"},"Junctional adhesion molecule B",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0007162|negative regulation of cell adhesion;GO:0007286|spermatid development;GO:0031642|negative regulation of myelination;GO:0045123|cellular extravasation;GO:0050901|leukocyte tethering or rolling;GO:0071593|lymphocyte aggregation;GO:0097241|hematopoietic stem cell migration to bone marrow;GO:0098609|cell-cell adhesion;GO:2000403|positive regulation of lymphocyte migration;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0036477|somatodendritic compartment;GO:0044291|cell-cell contact zone;GO:0070160|tight junction;GO:0098636|protein complex involved in cell adhesion;","GO:0005178|integrin binding;","K06735","JAM2, CD322; junctional adhesion molecule 2"]
["ENSRNOG00000019962",2609,167.8381132,363,23.43595505,7.161564904,2.840274871,0,0,"up","yes","Sars2","protein_coding","chr1:84028986-84040725:+","gi|157819737|ref|NP_001099710.1|",2578,0,"serine--tRNA ligase, mitochondrial [Rattus norvegicus]","gi|157819736|ref|NM_001106240.1|",1859,0,"Rattus norvegicus seryl-tRNA synthetase 2, mitochondrial (Sars2), mRNA","Q9JJL8",966,0,"Serine--tRNA ligase, mitochondrial","BB0226",268,{"v":2e-81,"d":"2.00E-81"},"COG0172","pfam00587","tRNA-synt_2b","tRNA synthetase class II core domain (G, H, P, S and T). Other tRNA synthetase sub-families are too dissimilar to be included. This domain is the core catalytic domain of tRNA synthetases and includes glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases.","GO:0006434|seryl-tRNA aminoacylation;GO:0070158|mitochondrial seryl-tRNA aminoacylation;GO:0097056|selenocysteinyl-tRNA(Sec) biosynthetic process;","GO:0005739|mitochondrion;","GO:0000049|tRNA binding;GO:0004828|serine-tRNA ligase activity;GO:0005524|ATP binding;","K01875","SARS, serS; seryl-tRNA synthetase [EC:6.1.1.11]"]
["ENSRNOG00000017243",4114,264.6554227,1080,69.72680843,3.795605,1.924329862,0,0,"up","yes","Bnip3","protein_coding","chr1:193708167-193725359:-","gi|16758160|ref|NP_445872.1|",711,{"v":2e-84,"d":"2.00E-84"},"BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [Rattus norvegicus]","gi|186973219|gb|AC131400.5|",2082,0,"Rattus norvegicus BAC CH230-139P17 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","O55003",276,{"v":4e-85,"d":"4.00E-85"},"BCL2/adenovirus E1B 19 kDa protein-interacting protein 3",".",".",".",".","pfam06553","BNIP3","BNIP3. This family consists of several mammalian specific BCL2/adenovirus E1B 19-kDa protein-interacting protein 3 or BNIP3 sequences. BNIP3 belongs to the Bcl-2 homology 3 (BH3)-only family, a Bcl-2-related family possessing an atypical Bcl-2 homology 3 (BH3) domain, which regulates PCD from mitochondrial sites by selective Bcl-2/Bcl-XL interactions. BNIP3 family members contain a C-terminal transmembrane domain that is required for their mitochondrial localisation, homodimerization, as well as regulation of their pro-apoptotic activities. BNIP3-mediated apoptosis has been reported to be independent of caspase activation and cytochrome c release and is characterized by early plasma membrane and mitochondrial damage, prior to the appearance of chromatin condensation or DNA fragmentation.","GO:0001666|response to hypoxia;GO:0006915|apoptotic process;GO:0008219|cell death;GO:0009617|response to bacterium;GO:0010637|negative regulation of mitochondrial fusion;GO:0010659|cardiac muscle cell apoptotic process;GO:0010666|positive regulation of cardiac muscle cell apoptotic process;GO:0010821|regulation of mitochondrion organization;GO:0010917|negative regulation of mitochondrial membrane potential;GO:0010940|positive regulation of necrotic cell death;GO:0016239|positive regulation of macroautophagy;GO:0021987|cerebral cortex development;GO:0035694|mitochondrial protein catabolic process;GO:0043065|positive regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0043067|regulation of programmed cell death;GO:0043068|positive regulation of programmed cell death;GO:0043243|positive regulation of protein complex disassembly;GO:0043653|mitochondrial fragmentation involved in apoptotic process;GO:0045837|negative regulation of membrane potential;GO:0046902|regulation of mitochondrial membrane permeability;GO:0048102|autophagic cell death;GO:0048678|response to axon injury;GO:0048709|oligodendrocyte differentiation;GO:0050873|brown fat cell differentiation;GO:0051402|neuron apoptotic process;GO:0051561|positive regulation of mitochondrial calcium ion concentration;GO:0051607|defense response to virus;GO:0055093|response to hyperoxia;GO:0060548|negative regulation of cell death;GO:0070301|cellular response to hydrogen peroxide;GO:0071260|cellular response to mechanical stimulus;GO:0071279|cellular response to cobalt ion;GO:0071456|cellular response to hypoxia;GO:0072593|reactive oxygen species metabolic process;GO:0090141|positive regulation of mitochondrial fission;GO:0090200|positive regulation of release of cytochrome c from mitochondria;GO:0090649|response to oxygen-glucose deprivation;GO:0097193|intrinsic apoptotic signaling pathway;GO:0097345|mitochondrial outer membrane permeabilization;GO:1901998|toxin transport;GO:1902109|negative regulation of mitochondrial membrane permeability involved in apoptotic process;GO:1903599|positive regulation of autophagy of mitochondrion;GO:1903715|regulation of aerobic respiration;GO:1990144|intrinsic apoptotic signaling pathway in response to hypoxia;GO:2000378|negative regulation of reactive oxygen species metabolic process;","GO:0005634|nucleus;GO:0005635|nuclear envelope;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0005783|endoplasmic reticulum;GO:0014069|postsynaptic density;GO:0030425|dendrite;GO:0031307|integral component of mitochondrial outer membrane;GO:0031966|mitochondrial membrane;","GO:0005515|protein binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0051020|GTPase binding;","K15464","BNIP3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3"]
["ENSRNOG00000017434",4109,264.3337705,1079,69.66224657,3.794505396,1.923911846,0,0,"up","yes","Mgat3","protein_coding","chr7:111675730-111762026:+","gi|158341638|ref|NP_062112.2|",2717,0,"beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase [Rattus norvegicus]","gi|672059865|ref|XM_006242074.2|",4567,0,"PREDICTED: Rattus norvegicus mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase (Mgat3), transcript variant X3, mRNA","Q02527",1051,0,"Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase",".",".",".",".","pfam04724","Glyco_transf_17","Glycosyltransferase family 17. This family represents beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase (EC:2.4.1.144). This enzyme transfers the bisecting GlcNAc to the core mannose of complex N-glycans. The addition of this residue is regulated during development and has functional consequences for receptor signalling, cell adhesion, and tumor progression.","GO:0006044|N-acetylglucosamine metabolic process;GO:0006487|protein N-linked glycosylation;GO:0008104|protein localization;GO:0030334|regulation of cell migration;GO:0034599|cellular response to oxidative stress;GO:0050435|amyloid-beta metabolic process;GO:0050890|cognition;GO:0060070|canonical Wnt signaling pathway;GO:1902966|positive regulation of protein localization to early endosome;GO:1905166|negative regulation of lysosomal protein catabolic process;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0003830|beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity;GO:0016757|transferase activity, transferring glycosyl groups;","K00737","MGAT3; beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase [EC:2.4.1.144]"]
["ENSRNOG00000010800",5382,346.2264183,1789,115.5011669,2.997601042,1.583808384,0,0,"up","yes","Hadhb","protein_coding","chr6:26153578-26184869:-","gi|564355098|ref|XP_006239848.1|",2522,0,"PREDICTED: trifunctional enzyme subunit beta, mitochondrial isoform X2 [Rattus norvegicus]","gi|577019541|ref|NM_001289798.1|",1480,0,"Mus musculus hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit (Hadhb), transcript variant 1, mRNA","Q60587",976,0,"Trifunctional enzyme subunit beta, mitochondrial","YPO2746",325,{"v":7e-102,"d":"7.00E-102"},"COG0183","pfam00108","Thiolase_N","Thiolase, N-terminal domain. Thiolase is reported to be structurally related to beta-ketoacyl synthase (pfam00109), and also chalcone synthase.","GO:0006635|fatty acid beta-oxidation;","GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0005743|mitochondrial inner membrane;GO:0005783|endoplasmic reticulum;GO:0016507|mitochondrial fatty acid beta-oxidation multienzyme complex;GO:0042645|mitochondrial nucleoid;","GO:0003988|acetyl-CoA C-acyltransferase activity;GO:0044877|protein-containing complex binding;GO:0050633|acetyl-CoA C-myristoyltransferase activity;","K07509","HADHB; acetyl-CoA acyltransferase [EC:2.3.1.16]"]
["ENSRNOG00000002618",10840,697.3419499,5371,346.7617482,2.011011749,1.007921511,0,0,"up","yes","ENSRNOG00000002618","protein_coding","chr13:63427041-63446701:+","gi|564381052|ref|XP_006250050.1|",3375,0,"PREDICTED: influenza virus NS1A-binding protein isoform X1 [Rattus norvegicus]","gi|672074321|ref|XM_006249988.2|",2976,0,"PREDICTED: Rattus norvegicus influenza virus NS1A binding protein (Ivns1abp), transcript variant X1, mRNA","Q920Q8",1296,0,"Influenza virus NS1A-binding protein homolog",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.","GO:0008380|RNA splicing;GO:0009615|response to virus;GO:0031397|negative regulation of protein ubiquitination;GO:2001243|negative regulation of intrinsic apoptotic signaling pathway;","GO:0005634|nucleus;GO:0005829|cytosol;",".","K15046","IVNS1ABP, NS1BP; influenza virus NS1A-binding protein"]
["ENSRNOG00000001295",2924,188.1022013,517,33.37848144,5.635433163,2.494526506,0,0,"up","yes","S100b","protein_coding","chr20:12372881-12394743:-","gi|149043704|gb|EDL97155.1|",313,{"v":3e-36,"d":"3.00E-36"},"S100 protein, beta polypeptide, isoform CRA_a [Rattus norvegicus]","gi|672086144|ref|XM_008772868.1|",1484,0,"PREDICTED: Rattus norvegicus S100 calcium binding protein B (S100b), transcript variant X1, mRNA","P04631",139,{"v":1e-37,"d":"1.00E-37"},"Protein S100-B",".",".",".",".","pfam01023","S_100","S-100/ICaBP type calcium binding domain. The S-100 domain is a subfamily of the EF-hand calcium binding proteins.","GO:0007611|learning or memory;GO:0007613|memory;GO:0008284|positive regulation of cell proliferation;GO:0008360|regulation of cell shape;GO:0031643|positive regulation of myelination;GO:0043065|positive regulation of apoptotic process;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0048168|regulation of neuronal synaptic plasticity;GO:0048708|astrocyte differentiation;GO:0050806|positive regulation of synaptic transmission;GO:0051384|response to glucocorticoid;GO:0051597|response to methylmercury;GO:0060291|long-term synaptic potentiation;GO:0071456|cellular response to hypoxia;GO:2001015|negative regulation of skeletal muscle cell differentiation;","GO:0001726|ruffle;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0043025|neuronal cell body;GO:0043231|intracellular membrane-bounded organelle;GO:0048471|perinuclear region of cytoplasm;","GO:0005102|signaling receptor binding;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0008270|zinc ion binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0044548|S100 protein binding;GO:0048156|tau protein binding;GO:0048306|calcium-dependent protein binding;GO:0050786|RAGE receptor binding;","K23770","S100B; protein S100-B"]
["ENSRNOG00000063825",8549,549.960916,3845,248.2403504,2.215437237,1.147591456,0,0,"up","yes","ENSRNOG00000063825","lncRNA","chr6:14897763-14904196:-","gi|852808253|ref|XP_012892261.1|",286,{"v":2e-59,"d":"2.00E-59"},"PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC106001845 [Dipodomys ordii]","gi|50838839|gb|AC120237.5|",2904,0,"Rattus norvegicus 1 BAC CH230-453N3 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P31792",122,{"v":2e-26,"d":"2.00E-26"},"Pol polyprotein (Fragment)",".",".",".",".","pfam00429","TLV_coat","ENV polyprotein (coat polyprotein).",".",".",".",".","."]
["ENSRNOG00000017854",10273,660.8665915,5041,325.4563345,2.03058451,1.021895071,0,0,"up","yes","Ucp2","protein_coding","chr1:154839209-154845611:+","gi|148747399|ref|NP_062227.2|",1621,0,"mitochondrial uncoupling protein 2 [Rattus norvegicus]","gi|674274951|ref|NM_019354.3|",1599,0,"Rattus norvegicus uncoupling protein 2 (mitochondrial, proton carrier) (Ucp2), mRNA","P56500",629,0,"Mitochondrial uncoupling protein 2",".",".",".",".","pfam00153","Mito_carr","Mitochondrial carrier protein.","GO:0000303|response to superoxide;GO:0001666|response to hypoxia;GO:0006839|mitochondrial transport;GO:0007565|female pregnancy;GO:0007568|aging;GO:0009409|response to cold;GO:0009749|response to glucose;GO:0010942|positive regulation of cell death;GO:0032869|cellular response to insulin stimulus;GO:0032870|cellular response to hormone stimulus;GO:0034198|cellular response to amino acid starvation;GO:0043066|negative regulation of apoptotic process;GO:0051881|regulation of mitochondrial membrane potential;GO:0061179|negative regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0070542|response to fatty acid;GO:0071333|cellular response to glucose stimulus;GO:0097421|liver regeneration;GO:0120162|positive regulation of cold-induced thermogenesis;GO:1902600|proton transmembrane transport;GO:1990542|mitochondrial transmembrane transport;GO:1990845|adaptive thermogenesis;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0017077|oxidative phosphorylation uncoupler activity;","K15103","UCP2_3, SLC25A8_9; solute carrier family 25 (mitochondrial uncoupling protein), member 8/9"]
["ENSRNOG00000015461",9383,603.6125015,4426,285.7507908,2.112373862,1.078865195,0,0,"up","yes","Serpine2","protein_coding","chr9:81124804-81188826:-","gi|564368926|ref|XP_006245223.1|",2146,0,"PREDICTED: glia-derived nexin isoform X2 [Rattus norvegicus]","gi|672065520|ref|XM_008767212.1|",1989,0,"PREDICTED: Rattus norvegicus serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 (Serpine2), transcript variant X2, mRNA","P07092",815,0,"Glia-derived nexin","all0778",170,{"v":9E-46,"d":"9.00E-46"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0007566|embryo implantation;GO:0007596|blood coagulation;GO:0008285|negative regulation of cell proliferation;GO:0009314|response to radiation;GO:0009611|response to wounding;GO:0010466|negative regulation of peptidase activity;GO:0010544|negative regulation of platelet activation;GO:0010757|negative regulation of plasminogen activation;GO:0010766|negative regulation of sodium ion transport;GO:0010951|negative regulation of endopeptidase activity;GO:0010976|positive regulation of neuron projection development;GO:0014067|negative regulation of phosphatidylinositol 3-kinase signaling;GO:0021683|cerebellar granular layer morphogenesis;GO:0030195|negative regulation of blood coagulation;GO:0030308|negative regulation of cell growth;GO:0032940|secretion by cell;GO:0033363|secretory granule organization;GO:0042177|negative regulation of protein catabolic process;GO:0042628|mating plug formation;GO:0045861|negative regulation of proteolysis;GO:0045879|negative regulation of smoothened signaling pathway;GO:0048505|regulation of timing of cell differentiation;GO:0048711|positive regulation of astrocyte differentiation;GO:0050974|detection of mechanical stimulus involved in sensory perception;GO:0051966|regulation of synaptic transmission, glutamatergic;GO:0060291|long-term synaptic potentiation;GO:0060384|innervation;GO:0061108|seminal vesicle epithelium development;GO:0061110|dense core granule biogenesis;GO:0090331|negative regulation of platelet aggregation;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005829|cytosol;GO:0016020|membrane;GO:0031091|platelet alpha granule;GO:0031232|extrinsic component of external side of plasma membrane;GO:0031594|neuromuscular junction;GO:0043025|neuronal cell body;GO:0062023|collagen-containing extracellular matrix;","GO:0004867|serine-type endopeptidase inhibitor activity;GO:0005102|signaling receptor binding;GO:0005539|glycosaminoglycan binding;GO:0008201|heparin binding;","K16643","SERPINE2; glia-derived nexin"]
["ENSRNOG00000016636",4171,268.3222577,1157,74.69807162,3.592090824,1.844823828,0,0,"up","yes","Lpin3","protein_coding","chr3:149534051-149558327:+","gi|62079093|ref|NP_001014206.1|",4122,0,"phosphatidate phosphatase LPIN3 [Rattus norvegicus]","gi|672047572|ref|XM_006235489.2|",3482,0,"PREDICTED: Rattus norvegicus lipin 3 (Lpin3), transcript variant X2, mRNA","Q7TNN8",1451,0,"Phosphatidate phosphatase LPIN3","SPAC1952.13",253,{"v":8e-71,"d":"8.00E-71"},"COG5083","pfam08235","LNS2","LNS2 (Lipin/Ned1/Smp2). This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain (Pfam: PF04571) and phosphatidylinositol transfer proteins. SMP2 (also known as PAH1) is involved in plasmid maintenance and respiration, and has been identified as a Mg2+-dependent phosphatidate phosphatase (EC:3.1.3.4) that contains a haloacid dehalogenase (HAD)-like domain. Lipin proteins are involved in adipose tissue development and insulin resistance.","GO:0009062|fatty acid catabolic process;GO:0016311|dephosphorylation;GO:0019432|triglyceride biosynthetic process;GO:0032869|cellular response to insulin stimulus;GO:0044255|cellular lipid metabolic process;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0003713|transcription coactivator activity;GO:0008195|phosphatidate phosphatase activity;","K15728","LPIN; phosphatidate phosphatase LPIN [EC:3.1.3.4]"]
["ENSRNOG00000018796",4828,310.5873556,1545,99.74807317,3.113717846,1.638638219,0,0,"up","yes","Herpud1","protein_coding","chr19:10598417-10618424:-","gi|564394581|ref|XP_006255195.1|",2116,0,"PREDICTED: homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein isoform X1 [Rattus norvegicus]","gi|672084209|ref|XM_006255133.2|",2147,0,"PREDICTED: Rattus norvegicus homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 (Herpud1), transcript variant X1, mRNA","Q9JJK5",633,0,"Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein",".",".",".",".","pfam00240","ubiquitin","Ubiquitin family. This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) Nedd8, Elongin B, Rub1, and Parkin. A number of them are thought to carry a distinctive five-residue motif termed the proteasome-interacting motif (PIM), which may have a biologically significant role in protein delivery to proteasomes and recruitment of proteasomes to transcription sites.","GO:0006511|ubiquitin-dependent protein catabolic process;GO:0006874|cellular calcium ion homeostasis;GO:0006986|response to unfolded protein;GO:0016567|protein ubiquitination;GO:0030433|ubiquitin-dependent ERAD pathway;GO:0030968|endoplasmic reticulum unfolded protein response;GO:0030970|retrograde protein transport, ER to cytosol;GO:0031396|regulation of protein ubiquitination;GO:0032469|endoplasmic reticulum calcium ion homeostasis;GO:0034976|response to endoplasmic reticulum stress;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045047|protein targeting to ER;GO:1902235|regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:1902236|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:1903069|regulation of ER-associated ubiquitin-dependent protein catabolic process;GO:1903071|positive regulation of ER-associated ubiquitin-dependent protein catabolic process;GO:2001243|negative regulation of intrinsic apoptotic signaling pathway;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0044322|endoplasmic reticulum quality control compartment;GO:1990037|Lewy body core;","GO:0044325|ion channel binding;GO:1990756|protein binding, bridging involved in substrate recognition for ubiquitination;","K14027","HERPUD1, HERP; homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein"]
["ENSRNOG00000047023",2538,163.2706521,389,25.11456341,6.501034857,2.700669389,0,0,"up","yes","Aldh1l1","protein_coding","chr4:123060008-123106465:+","gi|380865476|sp|P28037.3|AL1L1_RAT",4472,0,"RecName: Full=Cytosolic 10-formyltetrahydrofolate dehydrogenase; Short=10-FTHFDH; Short=FDH; AltName: Full=Aldehyde dehydrogenase family 1 member L1; AltName: Full=FBP-CI","gi|57921066|gb|BC089101.1|",2825,0,"Rattus norvegicus aldehyde dehydrogenase 1 family, member L1, mRNA (cDNA clone MGC:105431 IMAGE:7306458), complete cds","P28037",1727,0,"Cytosolic 10-formyltetrahydrofolate dehydrogenase","YER073w",415,{"v":1e-130,"d":"1.00E-130"},"COG1012","pfam00171","Aldedh","Aldehyde dehydrogenase family. This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:1.2.1.3. Succinate-semialdehyde dehydrogenase EC:1.2.1.16. Lactaldehyde dehydrogenase EC:1.2.1.22. Benzaldehyde dehydrogenase EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase EC: 1.5.1.12. Acetaldehyde dehydrogenase EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase EC:1.2.1.41. This family also includes omega crystallin, an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.","GO:0006730|one-carbon metabolic process;GO:0009058|biosynthetic process;GO:0009258|10-formyltetrahydrofolate catabolic process;GO:0038183|bile acid signaling pathway;GO:0046654|tetrahydrofolate biosynthetic process;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0032991|protein-containing complex;","GO:0004029|aldehyde dehydrogenase (NAD) activity;GO:0004030|aldehyde dehydrogenase [NAD(P)+] activity;GO:0016155|formyltetrahydrofolate dehydrogenase activity;GO:0016620|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor;GO:0016742|hydroxymethyl-, formyl- and related transferase activity;GO:0033721|aldehyde dehydrogenase (NADP+) activity;GO:0044877|protein-containing complex binding;","K00289","ALDH1L; formyltetrahydrofolate dehydrogenase [EC:1.5.1.6]"]
["ENSRNOG00000018694",1960,126.0876588,165,10.65270684,11.83620846,3.565135105,0,0,"up","yes","Lipg","protein_coding","chr18:68514923-68536260:-","gi|60678260|ref|NP_001012759.1|",2677,0,"endothelial lipase precursor [Rattus norvegicus]","gi|60678259|ref|NM_001012741.1|",1586,0,"Rattus norvegicus lipase G, endothelial type (Lipg), mRNA","Q8VBX1",1035,0,"Endothelial lipase",".",".",".",".","pfam00151","Lipase","Lipase.","GO:0006633|fatty acid biosynthetic process;GO:0007584|response to nutrient;GO:0008283|cell proliferation;GO:0010983|positive regulation of high-density lipoprotein particle clearance;GO:0016042|lipid catabolic process;GO:0019433|triglyceride catabolic process;GO:0032376|positive regulation of cholesterol transport;GO:0034375|high-density lipoprotein particle remodeling;GO:0042632|cholesterol homeostasis;GO:0043691|reverse cholesterol transport;GO:0050746|regulation of lipoprotein metabolic process;GO:0055091|phospholipid homeostasis;","GO:0005615|extracellular space;GO:0005769|early endosome;GO:0005794|Golgi apparatus;GO:0009986|cell surface;","GO:0003674|molecular_function;GO:0004465|lipoprotein lipase activity;GO:0004620|phospholipase activity;GO:0004806|triglyceride lipase activity;GO:0008201|heparin binding;GO:0008970|phospholipase A1 activity;GO:0016298|lipase activity;GO:0052739|phosphatidylserine 1-acylhydrolase activity;GO:0052740|1-acyl-2-lysophosphatidylserine acylhydrolase activity;","K22284","LIPG; endothelial lipase [EC:3.1.1.3]"]
["ENSRNOG00000015514",7374,474.3726512,3166,204.4028477,2.320773201,1.214605542,0,0,"up","yes","Bcat1","protein_coding","chr4:177964834-178046597:-","gi|8392971|ref|NP_058949.1|",2082,0,"branched-chain-amino-acid aminotransferase, cytosolic [Rattus norvegicus]","gi|56799398|ref|NM_017253.2|",2453,0,"Rattus norvegicus branched chain amino acid transaminase 1, cytosolic (Bcat1), mRNA","P54690",806,0,"Branched-chain-amino-acid aminotransferase, cytosolic","YJR148w",331,{"v":1e-102,"d":"1.00E-102"},"COG0115","pfam01063","Aminotran_4","Aminotransferase class IV. The D-amino acid transferases (D-AAT) are required by bacteria to catalyse the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.","GO:0008150|biological_process;GO:0008652|cellular amino acid biosynthetic process;GO:0009082|branched-chain amino acid biosynthetic process;GO:0009083|branched-chain amino acid catabolic process;GO:0009098|leucine biosynthetic process;GO:0009099|valine biosynthetic process;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;","GO:0004084|branched-chain-amino-acid transaminase activity;GO:0042802|identical protein binding;GO:0050048|L-leucine:2-oxoglutarate aminotransferase activity;GO:0052654|L-leucine transaminase activity;GO:0052655|L-valine transaminase activity;GO:0052656|L-isoleucine transaminase activity;","K00826","E2.6.1.42, ilvE; branched-chain amino acid aminotransferase [EC:2.6.1.42]"]
["ENSRNOG00000023463",6748,434.1017969,2761,178.2552945,2.435281365,1.284088466,0,0,"up","yes","Parp9","protein_coding","chr11:64780981-64815455:-","gi|672071140|ref|XP_008766949.1|",4237,0,"PREDICTED: poly [ADP-ribose] polymerase 9 isoform X2 [Rattus norvegicus]","gi|672071139|ref|XM_008768727.1|",3231,0,"PREDICTED: Rattus norvegicus poly (ADP-ribose) polymerase family, member 9 (Parp9), transcript variant X1, mRNA","Q8CAS9",1276,0,"Poly [ADP-ribose] polymerase 9","TM0508_2",94,{"v":2e-20,"d":"2.00E-20"},"COG2110","pfam01661","Macro","Macro domain. This domain is an ADP-ribose binding module. It is found in a number of otherwise unrelated proteins. It is found at the C-terminus of the macro-H2A histone protein. This domain is found in the non-structural proteins of several types of ssRNA viruses such as NSP3 from alphaviruses. This domain is also found on its own in a family of proteins from bacteria, archaebacteria, and eukaryotes.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0002230|positive regulation of defense response to virus by host;GO:0006302|double-strand break repair;GO:0006471|protein ADP-ribosylation;GO:0008150|biological_process;GO:0010608|posttranscriptional regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0035563|positive regulation of chromatin binding;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0043086|negative regulation of catalytic activity;GO:0045893|positive regulation of transcription, DNA-templated;GO:0060330|regulation of response to interferon-gamma;GO:0060335|positive regulation of interferon-gamma-mediated signaling pathway;GO:0070212|protein poly-ADP-ribosylation;GO:1900182|positive regulation of protein localization to nucleus;GO:2001034|positive regulation of double-strand break repair via nonhomologous end joining;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;GO:0032991|protein-containing complex;GO:0090734|site of DNA damage;","GO:0003674|molecular_function;GO:0003714|transcription corepressor activity;GO:0003950|NAD+ ADP-ribosyltransferase activity;GO:0004857|enzyme inhibitor activity;GO:0019899|enzyme binding;GO:0042393|histone binding;GO:0044389|ubiquitin-like protein ligase binding;GO:0072570|ADP-D-ribose binding;GO:0097677|STAT family protein binding;GO:1990404|protein ADP-ribosylase activity;","K15260","PARP9; poly [ADP-ribose] polymerase 9 [EC:2.4.2.30]"]
["ENSRNOG00000001765",2920,187.8448795,580,37.4458786,5.016436695,2.326662944,0,0,"up","yes","Slc51a","protein_coding","chr11:68299086-68313485:+","gi|157819283|ref|NP_001100557.1|",1654,0,"organic solute transporter subunit alpha [Rattus norvegicus]","gi|157819282|ref|NM_001107087.1|",1600,0,"Rattus norvegicus solute carrier family 51, alpha subunit (Slc51a), mRNA","Q8R000",614,0,"Organic solute transporter subunit alpha",".",".",".",".","pfam03619","Solute_trans_a","Organic solute transporter Ostalpha. This family is a transmembrane organic solute transport protein. In vertebrates these proteins form a complex with Ostbeta, and function as bile transporters. In plants they may transport brassinosteroid-like compounds and act as regulators of cell death.","GO:0006810|transport;GO:0015721|bile acid and bile salt transport;GO:0032782|bile acid secretion;GO:0055085|transmembrane transport;GO:0071702|organic substance transport;","GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0032991|protein-containing complex;","GO:0005215|transporter activity;GO:0015125|bile acid transmembrane transporter activity;GO:0022857|transmembrane transporter activity;GO:0042803|protein homodimerization activity;GO:0046982|protein heterodimerization activity;","K14360","OSTALPHA, OSTA, SLC51A1; organic solute transporter subunit alpha"]
["ENSRNOG00000038047",2396,154.1357299,353,22.79033646,6.763205544,2.7577072,0,0,"up","yes","Mt1","protein_coding","chr17:74786654-74787135:+",".",".",".",".","gi|328927102|ref|NG_006919.3|",482,0,"Rattus norvegicus metallothionein 1a pseudogene (LOC100125598) on chromosome 17",".",".",".",".",".",".",".",".","pfam00131","Metallothio","Metallothionein.","GO:0006875|cellular metal ion homeostasis;GO:0006882|cellular zinc ion homeostasis;GO:0007263|nitric oxide mediated signal transduction;GO:0010043|response to zinc ion;GO:0010273|detoxification of copper ion;GO:0043524|negative regulation of neuron apoptotic process;GO:0045926|negative regulation of growth;GO:0046686|response to cadmium ion;GO:0071247|cellular response to chromate;GO:0071276|cellular response to cadmium ion;GO:0071280|cellular response to copper ion;GO:0071294|cellular response to zinc ion;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0005829|cytosol;","GO:0003674|molecular_function;GO:0005507|copper ion binding;GO:0008270|zinc ion binding;GO:0046872|metal ion binding;","K14739","MT1_2; metallothionein 1/2"]
["ENSRNOG00000051563",2104,135.3512419,242,15.62397004,8.663050532,3.114875133,0,0,"up","yes","Giot1","protein_coding","chr7:10202982-10237099:-","gi|149034696|gb|EDL89433.1|",3512,0,"rCG29351 [Rattus norvegicus]","gi|19424247|ref|NM_133563.1|",2544,0,"Rattus norvegicus gonadotropin inducible ovarian transcription factor 1 (Giot1), mRNA","Q8N972",582,0,"Zinc finger protein 709",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0000122|negative regulation of transcription by RNA polymerase II;","GO:0005737|cytoplasm;","GO:0046872|metal ion binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSRNOG00000028711",3089,198.7167236,684,44.160312,4.499894012,2.169891021,0,0,"up","yes","Dgat1","protein_coding","chr7:108218524-108234299:-","gi|26453324|dbj|BAC43739.1|",2221,0,"diacylglycerol acyltransferase [Rattus norvegicus]","gi|26453331|dbj|AB062763.1|",1457,0,"Rattus norvegicus DGAT mRNA for diacylglycerol acyltransferase, complete cds, strain:Sprague-Dawley","Q9ERM3",842,0,"Diacylglycerol O-acyltransferase 1","ECU10g0300",138,{"v":5e-34,"d":"5.00E-34"},"COG5056","pfam03062","MBOAT","MBOAT, membrane-bound O-acyltransferase family. The MBOAT (membrane bound O-acyl transferase) family of membrane proteins contains a variety of acyltransferase enzymes. A conserved histidine has been suggested to be the active site residue.","GO:0006640|monoacylglycerol biosynthetic process;GO:0010867|positive regulation of triglyceride biosynthetic process;GO:0019432|triglyceride biosynthetic process;GO:0019915|lipid storage;GO:0030073|insulin secretion;GO:0034379|very-low-density lipoprotein particle assembly;GO:0035336|long-chain fatty-acyl-CoA metabolic process;GO:0042572|retinol metabolic process;GO:0044752|response to human chorionic gonadotropin;GO:0046321|positive regulation of fatty acid oxidation;GO:0046339|diacylglycerol metabolic process;GO:0046486|glycerolipid metabolic process;GO:0055089|fatty acid homeostasis;GO:1901738|regulation of vitamin A metabolic process;GO:1902224|ketone body metabolic process;GO:1903998|regulation of eating behavior;GO:1904729|regulation of intestinal lipid absorption;GO:2000491|positive regulation of hepatic stellate cell activation;","GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0003846|2-acylglycerol O-acyltransferase activity;GO:0004144|diacylglycerol O-acyltransferase activity;GO:0005504|fatty acid binding;GO:0008374|O-acyltransferase activity;GO:0016746|transferase activity, transferring acyl groups;GO:0019992|diacylglycerol binding;GO:0042802|identical protein binding;GO:0050252|retinol O-fatty-acyltransferase activity;","K11155","DGAT1; diacylglycerol O-acyltransferase 1 [EC:2.3.1.20 2.3.1.75 2.3.1.76]"]
["ENSRNOG00000056728",6874,442.2074321,2908,187.7458879,2.355350826,1.235941963,0,0,"up","yes","ENSRNOG00000056728","protein_coding","chrX:152201098-152220801:-","gi|8393381|ref|NP_058702.1|",2795,0,"glucose-6-phosphate 1-dehydrogenase [Rattus norvegicus]","gi|158262046|ref|NM_017006.2|",1661,0,"Rattus norvegicus glucose-6-phosphate dehydrogenase (G6pd), mRNA","P05370",1081,0,"Glucose-6-phosphate 1-dehydrogenase","YNL241c",459,{"v":1e-152,"d":"1.00E-152"},"COG0364","pfam02781","G6PD_C","Glucose-6-phosphate dehydrogenase, C-terminal domain.","GO:0001998|angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure;GO:0002033|angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure;GO:0006006|glucose metabolic process;GO:0006098|pentose-phosphate shunt;GO:0006695|cholesterol biosynthetic process;GO:0006739|NADP metabolic process;GO:0006740|NADPH regeneration;GO:0006741|NADP biosynthetic process;GO:0006749|glutathione metabolic process;GO:0006979|response to oxidative stress;GO:0009051|pentose-phosphate shunt, oxidative branch;GO:0010041|response to iron(III) ion;GO:0010734|negative regulation of protein glutathionylation;GO:0014070|response to organic cyclic compound;GO:0019322|pentose biosynthetic process;GO:0021762|substantia nigra development;GO:0032094|response to food;GO:0034599|cellular response to oxidative stress;GO:0040014|regulation of multicellular organism growth;GO:0043249|erythrocyte maturation;GO:0043523|regulation of neuron apoptotic process;GO:0045471|response to ethanol;GO:0046390|ribose phosphate biosynthetic process;GO:0048821|erythrocyte development;GO:0051156|glucose 6-phosphate metabolic process;GO:0061052|negative regulation of cell growth involved in cardiac muscle cell development;GO:1904879|positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel;GO:2000378|negative regulation of reactive oxygen species metabolic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0009898|cytoplasmic side of plasma membrane;GO:0034451|centriolar satellite;GO:0043231|intracellular membrane-bounded organelle;","GO:0004345|glucose-6-phosphate dehydrogenase activity;GO:0005536|glucose binding;GO:0030246|carbohydrate binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0050661|NADP binding;","K00036","G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]"]
["ENSRNOG00000006331",7004,450.570389,2995,193.3627697,2.330181709,1.220442461,0,0,"up","yes","Elovl5","protein_coding","chr8:78790846-78857284:+","gi|19705493|ref|NP_599209.1|",1501,0,"elongation of very long chain fatty acids protein 5 [Rattus norvegicus]","gi|564364592|ref|XM_006243417.1|",1433,0,"PREDICTED: Rattus norvegicus ELOVL fatty acid elongase 5 (Elovl5), transcript variant X1, mRNA","Q920L7",582,0,"Elongation of very long chain fatty acids protein 5",".",".",".",".","pfam01151","ELO","GNS1/SUR4 family. Members of this family are involved in long chain fatty acid elongation systems that produce the 26-carbon precursors for ceramide and sphingolipid synthesis. Predicted to be integral membrane proteins, in eukaryotes they are probably located on the endoplasmic reticulum. Yeast ELO3 affects plasma membrane H+-ATPase activity, and may act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1.","GO:0006636|unsaturated fatty acid biosynthetic process;GO:0019367|fatty acid elongation, saturated fatty acid;GO:0030148|sphingolipid biosynthetic process;GO:0034625|fatty acid elongation, monounsaturated fatty acid;GO:0034626|fatty acid elongation, polyunsaturated fatty acid;GO:0035338|long-chain fatty-acyl-CoA biosynthetic process;GO:0042761|very long-chain fatty acid biosynthetic process;GO:0045723|positive regulation of fatty acid biosynthetic process;","GO:0005783|endoplasmic reticulum;GO:0030176|integral component of endoplasmic reticulum membrane;GO:0030425|dendrite;GO:0043025|neuronal cell body;GO:0097447|dendritic tree;","GO:0009922|fatty acid elongase activity;GO:0102336|3-oxo-arachidoyl-CoA synthase activity;GO:0102337|3-oxo-cerotoyl-CoA synthase activity;GO:0102338|3-oxo-lignoceronyl-CoA synthase activity;GO:0102756|very-long-chain 3-ketoacyl-CoA synthase activity;","K10244","ELOVL5; elongation of very long chain fatty acids protein 5 [EC:2.3.1.199]"]
["ENSRNOG00000029726",5483,352.7237926,2034,131.3188225,2.686010929,1.425465175,0,0,"up","yes","Gstm1","protein_coding","chr2:195649845-195655411:-","gi|149025664|gb|EDL81907.1|",1020,{"v":5e-127,"d":"5.00E-127"},"rCG29047, isoform CRA_b [Rattus norvegicus]","gi|298900992|emb|FQ213696.1|",788,0,"Rattus norvegicus TL0AAA46YE12 mRNA sequence","P04905",397,{"v":2e-128,"d":"2.00E-128"},"Glutathione S-transferase Mu 1",".",".",".",".","pfam00043","GST_C","Glutathione S-transferase, C-terminal domain. GST conjugates reduced glutathione to a variety of targets including S-crystallin from squid, the eukaryotic elongation factor 1-gamma, the HSP26 family of stress-related proteins and auxin-regulated proteins in plants. Stringent starvation proteins in Escherichia coli are also included in the alignment but are not known to have GST activity.     The glutathione molecule binds in a cleft between N and C-terminal domains. The catalytically important residues are proposed to reside in the N-terminal domain. In plants, GSTs are encoded by a large gene family (48 GST genes in Arabidopsis) and can be divided into the phi, tau, theta, zeta, and lambda classes.","GO:0006693|prostaglandin metabolic process;GO:0006749|glutathione metabolic process;GO:0007568|aging;GO:0007608|sensory perception of smell;GO:0009410|response to xenobiotic stimulus;GO:0010038|response to metal ion;GO:0010226|response to lithium ion;GO:0010288|response to lead ion;GO:0018916|nitrobenzene metabolic process;GO:0042178|xenobiotic catabolic process;GO:0043200|response to amino acid;GO:0045471|response to ethanol;GO:0046677|response to antibiotic;GO:0048678|response to axon injury;GO:0051122|hepoxilin biosynthetic process;GO:0070458|cellular detoxification of nitrogen compound;GO:0071466|cellular response to xenobiotic stimulus;GO:1901687|glutathione derivative biosynthetic process;","GO:0005576|extracellular region;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0032991|protein-containing complex;GO:0045171|intercellular bridge;","GO:0004364|glutathione transferase activity;GO:0005496|steroid binding;GO:0016151|nickel cation binding;GO:0019899|enzyme binding;GO:0019901|protein kinase binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0043295|glutathione binding;","K00799","GST, gst; glutathione S-transferase [EC:2.5.1.18]"]
["ENSRNOG00000007237",4345,279.5157539,1364,88.06237657,3.174065529,1.666331913,0,0,"up","yes","Id2","protein_coding","chr6:41728946-41744400:-","gi|109791|pir||A41689",776,{"v":2e-98,"d":"2.00E-98"},"DNA-binding protein inhibitor Id-2 - mouse","gi|298900958|emb|FQ213662.1|",1282,0,"Rattus norvegicus TL0AAA46YH20 mRNA sequence","P41137",272,{"v":9e-89,"d":"9.00E-89"},"DNA-binding protein inhibitor ID-2",".",".",".",".","pfam00010","HLH","Helix-loop-helix DNA-binding domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001656|metanephros development;GO:0001779|natural killer cell differentiation;GO:0001966|thigmotaxis;GO:0002521|leukocyte differentiation;GO:0003149|membranous septum morphogenesis;GO:0003166|bundle of His development;GO:0007507|heart development;GO:0007623|circadian rhythm;GO:0008284|positive regulation of cell proliferation;GO:0008344|adult locomotory behavior;GO:0009649|entrainment of circadian clock;GO:0010468|regulation of gene expression;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0014003|oligodendrocyte development;GO:0019216|regulation of lipid metabolic process;GO:0021772|olfactory bulb development;GO:0030154|cell differentiation;GO:0030182|neuron differentiation;GO:0032922|circadian regulation of gene expression;GO:0033598|mammary gland epithelial cell proliferation;GO:0042752|regulation of circadian rhythm;GO:0043153|entrainment of circadian clock by photoperiod;GO:0043353|enucleate erythrocyte differentiation;GO:0043392|negative regulation of DNA binding;GO:0043433|negative regulation of DNA-binding transcription factor activity;GO:0045475|locomotor rhythm;GO:0045578|negative regulation of B cell differentiation;GO:0045600|positive regulation of fat cell differentiation;GO:0045648|positive regulation of erythrocyte differentiation;GO:0045651|positive regulation of macrophage differentiation;GO:0045664|regulation of neuron differentiation;GO:0045665|negative regulation of neuron differentiation;GO:0045668|negative regulation of osteoblast differentiation;GO:0045777|positive regulation of blood pressure;GO:0045787|positive regulation of cell cycle;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0048468|cell development;GO:0048469|cell maturation;GO:0048541|Peyer's patch development;GO:0048557|embryonic digestive tract morphogenesis;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0048663|neuron fate commitment;GO:0048667|cell morphogenesis involved in neuron differentiation;GO:0048711|positive regulation of astrocyte differentiation;GO:0048715|negative regulation of oligodendrocyte differentiation;GO:0051148|negative regulation of muscle cell differentiation;GO:0051726|regulation of cell cycle;GO:0060612|adipose tissue development;GO:0060749|mammary gland alveolus development;GO:0061030|epithelial cell differentiation involved in mammary gland alveolus development;GO:0061031|endodermal digestive tract morphogenesis;GO:0071285|cellular response to lithium ion;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0090398|cellular senescence;GO:1904797|negative regulation of core promoter binding;GO:2000045|regulation of G1/S transition of mitotic cell cycle;GO:2000177|regulation of neural precursor cell proliferation;","GO:0000785|chromatin;GO:0000791|euchromatin;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0032991|protein-containing complex;","GO:0005515|protein binding;GO:0044325|ion channel binding;GO:0046983|protein dimerization activity;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;GO:0140110|transcription regulator activity;","K17693","ID2; DNA-binding protein inhibitor ID2"]
["ENSRNOG00000064007",3264,209.9745502,788,50.87474541,4.127284541,2.045192903,0,0,"up","yes","ENSRNOG00000064007","protein_coding","chrX:40582255-40585197:-","gi|947316624|ref|XP_014448704.1|",568,{"v":5e-88,"d":"5.00E-88"},"PREDICTED: endogenous retrovirus group K member 18 Pol protein-like [Tupaia chinensis]","gi|153791782|ref|NG_006339.2|",1123,0,"Rattus norvegicus vomeronasal 2 receptor, pseudogene 55 (Vom2r-ps55) on chromosome 1","P04026",210,{"v":2e-81,"d":"2.00E-81"},"Intracisternal A-particle Pol-related polyprotein (Fragment)",".",".",".",".","pfam00665","rve","Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyses the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.",".",".",".",".","."]
["ENSRNOG00000012561",3253,209.2669154,808,52.1659826,4.01155897,2.004163005,0,0,"up","yes","Arhgef10","protein_coding","chr16:74647153-74738173:-","gi|392354094|ref|XP_002728482.2|",6906,0,"PREDICTED: rho guanine nucleotide exchange factor 10 isoform X2 [Rattus norvegicus]","gi|672080638|ref|XM_006253400.2|",5569,0,"PREDICTED: Rattus norvegicus Rho guanine nucleotide exchange factor (GEF) 10 (Arhgef10), transcript variant X2, mRNA","Q8C033",2383,0,"Rho guanine nucleotide exchange factor 10","SPCC645.07",55.5,2e-06,"COG5422","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0022011|myelination in peripheral nervous system;GO:0030036|actin cytoskeleton organization;GO:0035023|regulation of Rho protein signal transduction;GO:0051298|centrosome duplication;GO:0051496|positive regulation of stress fiber assembly;GO:0090307|mitotic spindle assembly;GO:0090630|activation of GTPase activity;","GO:0005813|centrosome;GO:0005829|cytosol;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0019894|kinesin binding;","K16727","ARHGEF10; Rho guanine nucleotide exchange factor 10"]
["ENSRNOG00000002413",4606,296.3059983,1562,100.8456248,2.938213719,1.554939338,0,0,"up","yes","ENSRNOG00000002413","protein_coding","chrX:131644704-131755284:-","gi|62078949|ref|NP_001014130.1|",2758,0,"glypican-4 precursor [Rattus norvegicus]","gi|672088669|ref|XM_006257580.2|",2281,0,"PREDICTED: Rattus norvegicus glypican 4 (Gpc4), transcript variant X1, mRNA","P51655",1047,0,"Glypican-4",".",".",".",".","pfam01153","Glypican","Glypican.","GO:0008150|biological_process;GO:0009966|regulation of signal transduction;GO:0016055|Wnt signaling pathway;GO:0016477|cell migration;GO:0098696|regulation of neurotransmitter receptor localization to postsynaptic specialization membrane;GO:0099560|synaptic membrane adhesion;GO:1905475|regulation of protein localization to membrane;GO:1905606|regulation of presynapse assembly;","GO:0005575|cellular_component;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0045202|synapse;GO:0062023|collagen-containing extracellular matrix;GO:0098978|glutamatergic synapse;GO:0099026|anchored component of presynaptic membrane;","GO:0003674|molecular_function;","K08110","GPC4; glypican 4"]
["ENSRNOG00000011861",1536,98.81155305,71,4.583892036,21.55625662,4.430034762,0,0,"up","yes","Aadat","protein_coding","chr16:29509394-29544332:-","gi|8393641|ref|NP_058889.1|",2022,0,"kynurenine/alpha-aminoadipate aminotransferase, mitochondrial [Rattus norvegicus]","gi|672080048|ref|XM_006253067.2|",1326,0,"PREDICTED: Rattus norvegicus aminoadipate aminotransferase (Aadat), transcript variant X1, mRNA","Q64602",783,0,"Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial","SPCC569.07",225,{"v":2e-65,"d":"2.00E-65"},"COG1167","pfam00155","Aminotran_1_2","Aminotransferase class I and II.","GO:0006103|2-oxoglutarate metabolic process;GO:0006536|glutamate metabolic process;GO:0009058|biosynthetic process;GO:0033512|L-lysine catabolic process to acetyl-CoA via saccharopine;GO:0070189|kynurenine metabolic process;GO:0097052|L-kynurenine metabolic process;GO:1901605|alpha-amino acid metabolic process;","GO:0005739|mitochondrion;","GO:0003824|catalytic activity;GO:0008483|transaminase activity;GO:0016212|kynurenine-oxoglutarate transaminase activity;GO:0030170|pyridoxal phosphate binding;GO:0042803|protein homodimerization activity;GO:0047536|2-aminoadipate transaminase activity;","K00825","AADAT, KAT2; kynurenine/2-aminoadipate aminotransferase [EC:2.6.1.7 2.6.1.39]"]
["ENSRNOG00000061857",3979,255.9708135,1203,77.66791717,3.295708484,1.720588637,0,0,"up","yes","Mgst2","protein_coding","chr2:135693557-135715828:+","gi|157823501|ref|NP_001099900.1|",592,{"v":3e-74,"d":"3.00E-74"},"microsomal glutathione S-transferase 2 [Rattus norvegicus]","gi|157823500|ref|NM_001106430.1|",703,0,"Rattus norvegicus microsomal glutathione S-transferase 2 (Mgst2), mRNA","Q99735",194,{"v":8e-61,"d":"8.00E-61"},"Microsomal glutathione S-transferase 2",".",".",".",".","pfam01124","MAPEG","MAPEG family. This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolizm). It includes proteins such as Prostaglandin E synthase. This enzyme catalyses the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.","GO:0006629|lipid metabolic process;GO:0006750|glutathione biosynthetic process;GO:0010243|response to organonitrogen compound;GO:0019370|leukotriene biosynthetic process;GO:0032496|response to lipopolysaccharide;GO:0046466|membrane lipid catabolic process;GO:0050790|regulation of catalytic activity;GO:0098869|cellular oxidant detoxification;","GO:0005635|nuclear envelope;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0004364|glutathione transferase activity;GO:0004464|leukotriene-C4 synthase activity;GO:0004602|glutathione peroxidase activity;GO:0008047|enzyme activator activity;GO:0042802|identical protein binding;GO:0043295|glutathione binding;","K00799","GST, gst; glutathione S-transferase [EC:2.5.1.18]"]
["ENSRNOG00000009244",6248,401.9365778,2638,170.3141858,2.359971226,1.23876927,0,0,"up","yes","Abhd4","protein_coding","chr15:27704113-27716966:+","gi|157819991|ref|NP_001102336.1|",1902,0,"abhydrolase domain-containing protein 4 [Rattus norvegicus]","gi|672078084|ref|XM_006251995.2|",2766,0,"PREDICTED: Rattus norvegicus abhydrolase domain containing 4 (Abhd4), transcript variant X1, mRNA","Q8VD66",706,0,"Protein ABHD4","SPAC6G10.03c",123,{"v":9e-29,"d":"9.00E-29"},"COG0596","pfam12697","Abhydrolase_6","Alpha/beta hydrolase family. This family contains alpha/beta hydrolase enzymes of diverse specificity.","GO:0006654|phosphatidic acid biosynthetic process;GO:0055088|lipid homeostasis;GO:0070291|N-acylethanolamine metabolic process;GO:0070292|N-acylphosphatidylethanolamine metabolic process;","GO:0005739|mitochondrion;GO:0005811|lipid droplet;","GO:0004622|lysophospholipase activity;GO:0042171|lysophosphatidic acid acyltransferase activity;GO:0052689|carboxylic ester hydrolase activity;","K13698","ABHD4; abhydrolase domain-containing protein 4"]
["ENSRNOG00000020193",2715,174.6571397,586,37.83324976,4.616498471,2.206799009,0,0,"up","yes","Runx2","protein_coding","chr9:16167482-16492167:+","gi|564367401|ref|XP_006244612.1|",2639,0,"PREDICTED: runt-related transcription factor 2 isoform X2 [Rattus norvegicus]","gi|672064382|ref|XM_006244550.2|",5799,0,"PREDICTED: Rattus norvegicus runt-related transcription factor 2 (Runx2), transcript variant X2, mRNA","Q08775",1003,0,"Runt-related transcription factor 2",".",".",".",".","pfam00853","Runt","Runt domain.","GO:0001501|skeletal system development;GO:0001503|ossification;GO:0001649|osteoblast differentiation;GO:0001958|endochondral ossification;GO:0002051|osteoblast fate commitment;GO:0002062|chondrocyte differentiation;GO:0002063|chondrocyte development;GO:0002076|osteoblast development;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008284|positive regulation of cell proliferation;GO:0010468|regulation of gene expression;GO:0010628|positive regulation of gene expression;GO:0030097|hemopoiesis;GO:0030182|neuron differentiation;GO:0030217|T cell differentiation;GO:0030278|regulation of ossification;GO:0030509|BMP signaling pathway;GO:0032332|positive regulation of chondrocyte differentiation;GO:0035115|embryonic forelimb morphogenesis;GO:0040036|regulation of fibroblast growth factor receptor signaling pathway;GO:0042475|odontogenesis of dentin-containing tooth;GO:0042487|regulation of odontogenesis of dentin-containing tooth;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0045595|regulation of cell differentiation;GO:0045667|regulation of osteoblast differentiation;GO:0045669|positive regulation of osteoblast differentiation;GO:0045778|positive regulation of ossification;GO:0045879|negative regulation of smoothened signaling pathway;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048469|cell maturation;GO:0048701|embryonic cranial skeleton morphogenesis;GO:0048705|skeletal system morphogenesis;GO:0048863|stem cell differentiation;GO:0050790|regulation of catalytic activity;GO:0071773|cellular response to BMP stimulus;GO:1901522|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005737|cytoplasm;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987|proximal promoter sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003682|chromatin binding;GO:0003700|DNA-binding transcription factor activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0019904|protein domain specific binding;GO:0042826|histone deacetylase binding;GO:0043425|bHLH transcription factor binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09278","RUNX2, AML3; runt-related transcription factor 2"]
["ENSRNOG00000019981",6100,392.4156729,2563,165.4720463,2.371492235,1.245795145,0,0,"up","yes","Sdf4","protein_coding","chr5:166586390-166604521:+","gi|78126149|ref|NP_569096.2|",1726,0,"45 kDa calcium-binding protein [Rattus norvegicus]","gi|354784150|gb|JN948651.1|",1068,0,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Tnfrsf4:tm1e(EUCOMM)Wtsi; transgenic","Q91ZS3",619,0,"45 kDa calcium-binding protein",".",".",".",".","pfam13499","EF-hand_7","EF-hand domain pair.","GO:0009650|UV protection;GO:0017156|calcium ion regulated exocytosis;GO:0021549|cerebellum development;GO:0045444|fat cell differentiation;GO:0045471|response to ethanol;GO:0070625|zymogen granule exocytosis;GO:0099558|maintenance of synapse structure;","GO:0005737|cytoplasm;GO:0005770|late endosome;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005796|Golgi lumen;GO:0005886|plasma membrane;","GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0042802|identical protein binding;","K19934","SDF4; calcium-binding protein"]
["ENSRNOG00000056940",4079,262.4038574,1343,86.70657752,3.026343155,1.597575583,0,0,"up","yes","Cited2","protein_coding","chr1:12312160-12314897:+","gi|675654626|ref|XP_008993415.1|",1125,{"v":2e-144,"d":"2.00E-144"},"PREDICTED: cbp/p300-interacting transactivator 2 [Callithrix jacchus]","gi|56799415|ref|NM_053698.2|",1966,0,"Rattus norvegicus Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 (Cited2), mRNA","O35740",387,{"v":1E-127,"d":"1.00E-127"},"Cbp/p300-interacting transactivator 2",".",".",".",".","pfam04487","CITED","CITED. CITED, CBP/p300-interacting transactivator with ED-rich tail, are characterized by a conserved 32-amino acid sequence at the C-terminus. CITED proteins do not bind DNA directly and are thought to function as transcriptional co-activators.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001568|blood vessel development;GO:0001570|vasculogenesis;GO:0001666|response to hypoxia;GO:0001701|in utero embryonic development;GO:0001829|trophectodermal cell differentiation;GO:0001841|neural tube formation;GO:0001843|neural tube closure;GO:0001889|liver development;GO:0001892|embryonic placenta development;GO:0001944|vasculature development;GO:0001947|heart looping;GO:0002089|lens morphogenesis in camera-type eye;GO:0002244|hematopoietic progenitor cell differentiation;GO:0002521|leukocyte differentiation;GO:0003151|outflow tract morphogenesis;GO:0003156|regulation of animal organ formation;GO:0003197|endocardial cushion development;GO:0003281|ventricular septum development;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0007368|determination of left/right symmetry;GO:0007417|central nervous system development;GO:0007422|peripheral nervous system development;GO:0007507|heart development;GO:0007530|sex determination;GO:0007569|cell aging;GO:0008283|cell proliferation;GO:0008584|male gonad development;GO:0009612|response to mechanical stimulus;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0021602|cranial nerve morphogenesis;GO:0022409|positive regulation of cell-cell adhesion;GO:0030325|adrenal gland development;GO:0030336|negative regulation of cell migration;GO:0030511|positive regulation of transforming growth factor beta receptor signaling pathway;GO:0030851|granulocyte differentiation;GO:0034405|response to fluid shear stress;GO:0035360|positive regulation of peroxisome proliferator activated receptor signaling pathway;GO:0035802|adrenal cortex formation;GO:0035914|skeletal muscle cell differentiation;GO:0043066|negative regulation of apoptotic process;GO:0043627|response to estrogen;GO:0045787|positive regulation of cell cycle;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046697|decidualization;GO:0048536|spleen development;GO:0048538|thymus development;GO:0048596|embryonic camera-type eye morphogenesis;GO:0048821|erythrocyte development;GO:0060044|negative regulation of cardiac muscle cell proliferation;GO:0060136|embryonic process involved in female pregnancy;GO:0060349|bone morphogenesis;GO:0060411|cardiac septum morphogenesis;GO:0060412|ventricular septum morphogenesis;GO:0060971|embryonic heart tube left/right pattern formation;GO:0060972|left/right pattern formation;GO:0061156|pulmonary artery morphogenesis;GO:0061308|cardiac neural crest cell development involved in heart development;GO:0061371|determination of heart left/right asymmetry;GO:0061428|negative regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0070986|left/right axis specification;GO:0071363|cellular response to growth factor stimulus;GO:1900164|nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry;GO:2000020|positive regulation of male gonad development;","GO:0000785|chromatin;GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0032991|protein-containing complex;","GO:0003674|molecular_function;GO:0003682|chromatin binding;GO:0003713|transcription coactivator activity;GO:0003714|transcription corepressor activity;GO:0019904|protein domain specific binding;GO:0035035|histone acetyltransferase binding;GO:0046332|SMAD binding;GO:0050693|LBD domain binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;","K21361","CITED2; Cbp/p300-interacting transactivator 2"]
["ENSRNOG00000007808",1317,84.72318709,18,1.162113474,72.90440133,6.187934009,0,0,"up","yes","Nap1l5","protein_coding","chr4:88022569-88024654:-","gi|149033227|gb|EDL88028.1|",836,{"v":3e-104,"d":"3.00E-104"},"rCG52514 [Rattus norvegicus]","gi|112983817|ref|NM_001044293.1|",1606,0,"Rattus norvegicus nucleosome assembly protein 1-like 5 (Nap1l5), mRNA","Q5PPG6",195,{"v":3E-57,"d":"3.00E-57"},"Nucleosome assembly protein 1-like 5",".",".",".",".","pfam00956","NAP","Nucleosome assembly protein (NAP). NAP proteins are involved in moving histones into the nucleus, nucleosome assembly and chromatin fluidity. They affect the transcription of many genes.","GO:0006334|nucleosome assembly;","GO:0000785|chromatin;GO:0005634|nucleus;","GO:0003682|chromatin binding;GO:0042393|histone binding;","K11283","NAP1L5; nucleosome assembly protein 1-like 5"]
["ENSRNOG00000001374",2054,132.13472,314,20.27242393,6.517953673,2.704419098,0,0,"up","yes","Rasal1","protein_coding","chr12:35881270-35913727:-","gi|157820415|ref|NP_001101805.1|",4075,0,"rasGAP-activating-like protein 1 [Rattus norvegicus]","gi|157820414|ref|NM_001108335.1|",3238,0,"Rattus norvegicus RAS protein activator like 1 (GAP1 like) (Rasal1), mRNA","Q9Z268",1509,0,"RasGAP-activating-like protein 1",".",".",".",".","pfam00616","RasGAP","GTPase-activator protein for Ras-like GTPase. All alpha-helical domain that accelerates the GTPase activity of Ras, thereby \"switching\" it into an \"off\" position.","GO:0035556|intracellular signal transduction;GO:0043087|regulation of GTPase activity;GO:0046580|negative regulation of Ras protein signal transduction;GO:0071277|cellular response to calcium ion;GO:1903861|positive regulation of dendrite extension;","GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0005096|GTPase activator activity;GO:0005543|phospholipid binding;GO:0046872|metal ion binding;","K17632","RASAL1; RAS protein activator-like 1"]
["ENSRNOG00000021118",5443,350.150575,2206,142.4234624,2.458517502,1.297788626,{"v":6.5667E-307,"d":"6.57E-307"},{"v":1.267E-305,"d":"1.27E-305"},"up","yes","Nomo1","protein_coding","chr1:96505484-96556279:+","gi|157816949|ref|NP_001101954.1|",5880,0,"nodal modulator 1 precursor [Rattus norvegicus]","gi|157816948|ref|NM_001108484.1|",3990,0,"Rattus norvegicus nodal modulator 1 (Nomo1), mRNA","Q6GQT9",2235,0,"Nodal modulator 1",".",".",".",".","pfam13620","CarboxypepD_reg","Carboxypeptidase regulatory-like domain.",".","GO:0005789|endoplasmic reticulum membrane;","GO:0030246|carbohydrate binding;",".","."]
["ENSRNOG00000009715",6504,418.40517,2904,187.4876404,2.231641344,1.158105185,{"v":1.522e-306,"d":"1.52E-306"},{"v":2.9268E-305,"d":"2.93E-305"},"up","yes","Me1","protein_coding","chr8:87549043-87660304:-","gi|672062685|ref|XP_008764661.1|",2793,0,"PREDICTED: NADP-dependent malic enzyme isoform X1 [Rattus norvegicus]","gi|672062684|ref|XM_008766439.1|",3181,0,"PREDICTED: Rattus norvegicus malic enzyme 1, NADP(+)-dependent, cytosolic (Me1), transcript variant X1, mRNA","P13697",1074,0,"NADP-dependent malic enzyme","VC1188",410,{"v":5e-129,"d":"5.00E-129"},"COG0281","pfam03949","Malic_M","Malic enzyme, NAD binding domain.","GO:0006090|pyruvate metabolic process;GO:0006108|malate metabolic process;GO:0009725|response to hormone;GO:1902031|regulation of NADP metabolic process;","GO:0005739|mitochondrion;GO:0005829|cytosol;","GO:0004470|malic enzyme activity;GO:0004471|malate dehydrogenase (decarboxylating) (NAD+) activity;GO:0004473|malate dehydrogenase (decarboxylating) (NADP+) activity;GO:0008948|oxaloacetate decarboxylase activity;GO:0030145|manganese ion binding;GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0050661|NADP binding;GO:0051287|NAD binding;","K00029","E1.1.1.40, maeB; malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) [EC:1.1.1.40]"]
["ENSRNOG00000017237",3729,239.888204,1173,75.73106138,3.167632932,1.663405164,{"v":2.638e-304,"d":"2.64E-304"},{"v":4.9888E-303,"d":"4.99E-303"},"up","yes","Lama1","protein_coding","chr9:107692770-107817478:+","gi|312147379|ref|NP_001101707.2|",16083,0,"laminin subunit alpha-1 precursor [Rattus norvegicus]","gi|312147378|ref|NM_001108237.2|",10570,0,"Rattus norvegicus laminin subunit alpha 1 (Lama1), mRNA","P19137",5793,0,"Laminin subunit alpha-1",".",".",".",".","pfam00055","Laminin_N","Laminin N-terminal (Domain VI).","GO:0002011|morphogenesis of an epithelial sheet;GO:0006468|protein phosphorylation;GO:0007155|cell adhesion;GO:0007166|cell surface receptor signaling pathway;GO:0007411|axon guidance;GO:0008150|biological_process;GO:0009887|animal organ morphogenesis;GO:0009888|tissue development;GO:0030155|regulation of cell adhesion;GO:0030334|regulation of cell migration;GO:0031175|neuron projection development;GO:0043010|camera-type eye development;GO:0045198|establishment of epithelial cell apical/basal polarity;GO:0045995|regulation of embryonic development;GO:0048514|blood vessel morphogenesis;GO:0060041|retina development in camera-type eye;GO:0060441|epithelial tube branching involved in lung morphogenesis;GO:0060445|branching involved in salivary gland morphogenesis;GO:0061304|retinal blood vessel morphogenesis;","GO:0005575|cellular_component;GO:0005604|basement membrane;GO:0005606|laminin-1 complex;GO:0005608|laminin-3 complex;GO:0005615|extracellular space;GO:0005911|cell-cell junction;GO:0016020|membrane;GO:0031012|extracellular matrix;GO:0043256|laminin complex;","GO:0003674|molecular_function;GO:0005102|signaling receptor binding;GO:0005201|extracellular matrix structural constituent;GO:0008022|protein C-terminus binding;GO:0043208|glycosphingolipid binding;","K05637","LAMA1_2; laminin, alpha 1/2"]
["ENSRNOG00000013961",6616,425.610179,3028,195.493311,2.177108653,1.12241341,{"v":1.2841e-296,"d":"1.28E-296"},{"v":2.3811e-295,"d":"2.38E-295"},"up","yes","Ghitm","protein_coding","chr16:12885553-12897879:-","gi|54400718|ref|NP_001005908.1|",1579,0,"growth hormone-inducible transmembrane protein [Rattus norvegicus]","gi|298892334|emb|FQ217853.1|",1424,0,"Rattus norvegicus TL0ACA15YN07 mRNA sequence","Q5XIA8",612,0,"Growth hormone-inducible transmembrane protein","jhp0854",58.2,1E-8,"COG0670","pfam01027","Bax1-I","Inhibitor of apoptosis-promoting Bax1. Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner.","GO:0006915|apoptotic process;GO:0007007|inner mitochondrial membrane organization;GO:0090201|negative regulation of release of cytochrome c from mitochondria;","GO:0005739|mitochondrion;GO:0031305|integral component of mitochondrial inner membrane;",".","K21890","GHITM, DERP2, TMBIM5; growth hormone-inducible transmembrane protein"]
["ENSRNOG00000028356",3266,210.1032111,938,60.55902436,3.469395575,1.794684344,{"v":1.6796e-296,"d":"1.68E-296"},{"v":3.1044E-295,"d":"3.10E-295"},"up","yes","Chchd10","protein_coding","chr20:12725842-12732763:-","gi|55741551|ref|NP_001007009.1|",348,{"v":6e-36,"d":"6.00E-36"},"coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial [Rattus norvegicus]","gi|568966185|ref|XM_006512993.1|",677,0,"PREDICTED: Mus musculus coiled-coil-helix-coiled-coil-helix domain containing 10 (Chchd10), transcript variant X1, mRNA","Q8WYQ3",124,{"v":4e-32,"d":"4.00E-32"},"Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial",".",".",".",".","pfam06747","CHCH","CHCH domain. we have identified a conserved motif in the LOC118487 protein that we have called the CHCH motif. Alignment of this protein with related members showed the presence of three subgroups of proteins, which are called the S (Small), N (N-terminal extended) and C (C-terminal extended) subgroups. All three sub-groups of proteins have in common that they contain a predicted conserved [coiled coil 1]-[helix 1]-[coiled coil 2]-[helix 2] domain (CHCH domain). Within each helix of the CHCH domain, there are two cysteines present in a C-X9-C motif. The N-group contains an additional double helix domain, and each helix contains the C-X9-C motif. This family contains a number of characterized proteins: Cox19 protein - a nuclear gene of Saccharomyces cerevisiae, codes for an 11-kDa protein (Cox19p) required for expression of cytochrome oxidase. Because cox19 mutants are able to synthesize the mitochondrial and nuclear gene products of cytochrome oxidase, Cox19p probably functions post-translationally during assembly of the enzyme. Cox19p is present in the cytoplasm and mitochondria, where it exists as a soluble intermembrane protein. This dual location is similar to what was previously reported for Cox17p, a low molecular weight copper protein thought to be required for maturation of the CuA centre of subunit 2 of cytochrome oxidase. Cox19p have four conserved potential metal ligands, these are three cysteines and one histidine. Mrp10 - belongs to the class of yeast mitochondrial ribosomal proteins that are essential for translation. Eukaryotic NADH-ubiquinone oxidoreductase 19 kDa (NDUFA8) subunit. The CHCH domain was previously called DUF657.","GO:0006119|oxidative phosphorylation;GO:0007005|mitochondrion organization;GO:0030322|stabilization of membrane potential;GO:0031930|mitochondria-nucleus signaling pathway;GO:0051457|maintenance of protein location in nucleus;GO:0065003|protein-containing complex assembly;GO:0090144|mitochondrial nucleoid organization;GO:0099558|maintenance of synapse structure;GO:1901030|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;GO:1903109|positive regulation of mitochondrial transcription;GO:1903852|positive regulation of cristae formation;","GO:0005634|nucleus;GO:0005739|mitochondrion;GO:0005758|mitochondrial intermembrane space;GO:0061617|MICOS complex;",".","K22759","CHCHD10; coiled-coil-helix-coiled-coil-helix domain-containing protein 10"]
["ENSRNOG00000019383",2775,178.516966,687,44.35399758,4.024822467,2.008925148,{"v":4.3016e-293,"d":"4.30E-293"},{"v":7.7993e-292,"d":"7.80E-292"},"up","yes","Tef","protein_coding","chr7:113317283-113341783:+","gi|76362828|ref|NP_062067.2|",1166,{"v":9e-145,"d":"9.00E-145"},"thyrotroph embryonic factor [Rattus norvegicus]","gi|76362827|ref|NM_019194.2|",4155,0,"Rattus norvegicus thyrotrophic embryonic factor (Tef), mRNA","P41224",453,{"v":3e-146,"d":"3.00E-146"},"Thyrotroph embryonic factor",".",".",".",".","pfam07716","bZIP_2","Basic region leucine zipper.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048511|rhythmic process;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003690|double-stranded DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0042802|identical protein binding;GO:0043565|sequence-specific DNA binding;GO:0044877|protein-containing complex binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09058","TEF; thyrotrophic embryonic factor"]
["ENSRNOG00000010326",1722,110.7770146,211,13.62255239,8.131883909,3.023589619,{"v":7.3823e-290,"d":"7.38E-290"},{"v":1.3217e-288,"d":"1.32E-288"},"up","yes","Col20a1","protein_coding","chr3:168084560-168135309:+","gi|672017855|ref|XP_008773859.1|",5886,0,"PREDICTED: collagen alpha-1(XX) chain isoform X1 [Rattus norvegicus]","gi|672048486|ref|XM_008762605.1|",4177,0,"PREDICTED: Rattus norvegicus collagen, type XX, alpha 1 (Col20a1), transcript variant X6, mRNA","Q923P0",2105,0,"Collagen alpha-1(XX) chain","YDL226c",132,{"v":3e-31,"d":"3.00E-31"},"COG5347","pfam00092","VWA","von Willebrand factor type A domain.",".","GO:0005581|collagen trimer;GO:0005615|extracellular space;GO:0062023|collagen-containing extracellular matrix;",".","K24357","COL20A; collagen type XX alpha"]
["ENSRNOG00000016704",4075,262.1465356,1433,92.51714489,2.833491413,1.50258083,{"v":4.9673E-287,"d":"4.97E-287"},{"v":8.838e-286,"d":"8.84E-286"},"up","yes","Pcyox1","protein_coding","chr4:118830638-118842951:-","gi|21489987|ref|NP_659553.1|",2506,0,"prenylcysteine oxidase precursor [Rattus norvegicus]","gi|13242074|gb|AF332142.1|AF332142",3541,0,"Rattus norvegicus chloride ion pump-associated 55 kDa protein (Clp55) mRNA, complete cds","Q99ML5",969,0,"Prenylcysteine oxidase",".",".",".",".","pfam07156","Prenylcys_lyase","Prenylcysteine lyase. This family contains prenylcysteine lyases (EC:1.8.3.5) that are approximately 500 residues long. Prenylcysteine lyase is a FAD-dependent thioether oxidase that degrades a variety of prenylcysteines, producing free cysteine, an isoprenoid aldehyde and hydrogen peroxide as products of the reaction. It has been noted that this enzyme has considerable homology with ClP55, a 55 kDa protein that is associated with chloride ion pumps.","GO:0030327|prenylated protein catabolic process;GO:0030328|prenylcysteine catabolic process;GO:1902476|chloride transmembrane transport;","GO:0005764|lysosome;GO:0005886|plasma membrane;GO:0034361|very-low-density lipoprotein particle;","GO:0001735|prenylcysteine oxidase activity;","K05906","PCYOX1, FCLY; prenylcysteine oxidase / farnesylcysteine lyase [EC:1.8.3.5 1.8.3.6]"]
["ENSRNOG00000019189",2263,145.5797816,456,29.440208,4.944930471,2.305950236,{"v":3.5714e-284,"d":"3.57E-284"},{"v":6.2761e-283,"d":"6.28E-283"},"up","yes","Acat2","protein_coding","chr1:47695788-47752821:+","gi|33086552|gb|AAP92588.1|",4250,0,"Ab2-076 [Rattus norvegicus]","gi|33086551|gb|AY325187.1|",2381,0,"Rattus norvegicus Ab2-076 mRNA, complete cds","Q5XI22",671,0,"Acetyl-CoA acetyltransferase, cytosolic","CC0510",406,{"v":4e-131,"d":"4.00E-131"},"COG0183","pfam00108","Thiolase_N","Thiolase, N-terminal domain. Thiolase is reported to be structurally related to beta-ketoacyl synthase (pfam00109), and also chalcone synthase.","GO:0001889|liver development;GO:0006635|fatty acid beta-oxidation;GO:0006695|cholesterol biosynthetic process;GO:0007420|brain development;GO:0019408|dolichol biosynthetic process;GO:0031670|cellular response to nutrient;GO:0038183|bile acid signaling pathway;GO:0045797|positive regulation of intestinal cholesterol absorption;GO:0046952|ketone body catabolic process;GO:0071398|cellular response to fatty acid;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005777|peroxisome;GO:0005829|cytosol;","GO:0003985|acetyl-CoA C-acetyltransferase activity;GO:0016747|transferase activity, transferring acyl groups other than amino-acyl groups;","K00626","ACAT, atoB; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]"]
["ENSRNOG00000029441",3270,210.3605329,984,63.5288699,3.311258853,1.727379796,{"v":1.2877e-281,"d":"1.29E-281"},{"v":2.2559e-280,"d":"2.26E-280"},"up","yes","Klhl2","protein_coding","chr16:24860667-24973341:+","gi|487524588|sp|F1LZF0.3|KLHL2_RAT",3085,0,"RecName: Full=Kelch-like protein 2; AltName: Full=Mayven","gi|672029304|ref|XM_008772045.1|",2843,0,"PREDICTED: Rattus norvegicus kelch-like family member 2 (Klhl2), mRNA","F1LZF0",1194,0,"Kelch-like protein 2",".",".",".",".","pfam07707","BACK","BTB And C-terminal Kelch. This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).","GO:0016567|protein ubiquitination;","GO:0001726|ruffle;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0015629|actin cytoskeleton;GO:0030027|lamellipodium;GO:0031463|Cul3-RING ubiquitin ligase complex;","GO:0003779|actin binding;GO:0042802|identical protein binding;","K10443","KLHL2_3; kelch-like protein 2/3"]
["ENSRNOG00000016479",3350,215.5069679,1031,66.5632773,3.237625559,1.694936144,{"v":6.4313e-281,"d":"6.43E-281"},{"v":1.1199E-279,"d":"1.12E-279"},"up","yes","Plekhg4","protein_coding","chr19:33249706-33266357:+","gi|564395506|ref|XP_006255545.1|",5844,0,"PREDICTED: puratrophin-1 [Rattus norvegicus]","gi|672031236|ref|XM_008774228.1|",3828,0,"PREDICTED: Rattus norvegicus pleckstrin homology domain containing, family G (with RhoGef domain) member 4 (Plekhg4), mRNA","Q58EX7",1590,0,"Puratrophin-1",".",".",".",".","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0008150|biological_process;GO:0090630|activation of GTPase activity;","GO:0005575|cellular_component;","GO:0003674|molecular_function;GO:0005085|guanyl-nucleotide exchange factor activity;","K23860","PLEKHG4; pleckstrin homology domain-containing family G member 4"]
["ENSRNOG00000062360",7336,471.9280945,3614,233.3265608,2.022607683,1.016216513,{"v":7.5543e-280,"d":"7.55E-280"},{"v":1.3035E-278,"d":"1.30E-278"},"up","yes","ENSRNOG00000062360","protein_coding","chrX:17180474-17192351:+","gi|672032108|ref|XP_008756601.1|",1794,0,"PREDICTED: spindlin-2B, partial [Rattus norvegicus]","gi|672032107|ref|XM_008758379.1|",1160,0,"PREDICTED: Rattus norvegicus similar to Spindlin-like protein 2 (SPIN-2) (LOC367746), partial mRNA","Q5RA80",409,{"v":1e-129,"d":"1.00E-129"},"Spindlin-2",".",".",".",".","pfam02513","Spin-Ssty","Spin/Ssty Family. Spindlin (Spin) is a novel maternal transcript present in the unfertilised egg and early embryo. The Y-linked spermiogenesis -specific transcript (Ssty) is also expressed during gametogenesis and forms part of this Pfam family. Members of this family contain three copies of this 50 residue repeat. The repeat is predicted to contain four beta strands.",".",".",".",".","."]
["ENSRNOG00000019525",5526,355.4900014,2426,156.6270715,2.269658737,1.182475392,{"v":1.7071E-269,"d":"1.71E-269"},{"v":2.8591E-268,"d":"2.86E-268"},"up","yes","Hspa9","protein_coding","chr18:26535798-26554292:-","gi|410110929|ref|NP_001094128.2|",3246,0,"stress-70 protein, mitochondrial [Rattus norvegicus]","gi|410110928|ref|NM_001100658.2|",2832,0,"Rattus norvegicus heat shock protein family A member 9 (Hspa9), mRNA","P48721",1250,0,"Stress-70 protein, mitochondrial",".",".",".",".","pfam00012","HSP70","Hsp70 protein. Hsp70 chaperones help to fold many proteins. Hsp70 assisted folding involves repeated cycles of substrate binding and release. Hsp70 activity is ATP dependent. Hsp70 proteins are made up of two regions: the amino terminus is the ATPase domain and the carboxyl terminus is the substrate binding region.","GO:0006457|protein folding;GO:0006611|protein export from nucleus;GO:0009636|response to toxic substance;GO:0016226|iron-sulfur cluster assembly;GO:0030218|erythrocyte differentiation;GO:0034620|cellular response to unfolded protein;GO:0042026|protein refolding;GO:0045646|regulation of erythrocyte differentiation;GO:0045647|negative regulation of erythrocyte differentiation;GO:0046777|protein autophosphorylation;GO:0051085|chaperone cofactor-dependent protein refolding;GO:0051593|response to folic acid;GO:0060548|negative regulation of cell death;GO:0071347|cellular response to interleukin-1;GO:0097068|response to thyroxine;GO:1902037|negative regulation of hematopoietic stem cell differentiation;GO:1903707|negative regulation of hemopoiesis;","GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005759|mitochondrial matrix;GO:0042645|mitochondrial nucleoid;","GO:0005515|protein binding;GO:0005524|ATP binding;GO:0016887|ATPase activity;GO:0017134|fibroblast growth factor binding;GO:0019899|enzyme binding;GO:0031072|heat shock protein binding;GO:0031625|ubiquitin protein ligase binding;GO:0044183|protein binding involved in protein folding;GO:0051082|unfolded protein binding;GO:0051087|chaperone binding;GO:0051787|misfolded protein binding;","K04043","dnaK, HSPA9; molecular chaperone DnaK"]
["ENSRNOG00000008933",5789,372.4089067,2603,168.0545207,2.216000529,1.147958225,{"v":2.7552e-269,"d":"2.76E-269"},{"v":4.6011e-268,"d":"4.60E-268"},"up","yes","Plbd1","protein_coding","chr4:169472983-169529277:-","gi|62078583|ref|NP_001013949.1|",2775,0,"phospholipase B-like 1 precursor [Rattus norvegicus]","gi|62078582|ref|NM_001013927.1|",1933,0,"Rattus norvegicus phospholipase B domain containing 1 (Plbd1), mRNA","Q5U2V4",1074,0,"Phospholipase B-like 1",".",".",".",".","pfam04916","Phospholip_B","Phospholipase B. Phospholipase B (PLB) catalyses the hydrolytic cleavage of both acylester bonds of glycerophospholipids. This family of PLB enzymes has been identified in mammals, flies and nematodes but not in yeast. In Drosophila this protein was named LAMA for laminin ancestor since it is expressed in the neuronal and glial precursors that surround the lamina.","GO:0009395|phospholipid catabolic process;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005764|lysosome;","GO:0004620|phospholipase activity;",".","."]
["ENSRNOG00000042960",2256,145.1294685,490,31.63531123,4.587578339,2.197732794,{"v":2.7135e-267,"d":"2.71E-267"},{"v":4.5051e-266,"d":"4.51E-266"},"up","yes","Rgcc","protein_coding","chr15:54662483-54681141:-","gi|344253026|gb|EGW09130.1|",490,{"v":1E-56,"d":"1.00E-56"},"Response gene to complement 32 protein [Cricetulus griseus]","gi|16758927|ref|NM_054008.1|",497,0,"Rattus norvegicus regulator of cell cycle (Rgcc), mRNA","Q9Z2P4",177,{"v":4E-52,"d":"4.00E-52"},"Regulator of cell cycle RGCC",".",".",".",".","pfam15151","RGCC","Response gene to complement 32 protein family. This family of proteins is found in eukaryotes. Proteins in this family are typically between 44 and 130 amino acids in length. There is a conserved KLGDT sequence motif.","GO:0000079|regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0001100|negative regulation of exit from mitosis;GO:0001818|negative regulation of cytokine production;GO:0001819|positive regulation of cytokine production;GO:0001937|negative regulation of endothelial cell proliferation;GO:0003331|positive regulation of extracellular matrix constituent secretion;GO:0006956|complement activation;GO:0008285|negative regulation of cell proliferation;GO:0010628|positive regulation of gene expression;GO:0010718|positive regulation of epithelial to mesenchymal transition;GO:0016525|negative regulation of angiogenesis;GO:0032147|activation of protein kinase activity;GO:0032967|positive regulation of collagen biosynthetic process;GO:0043537|negative regulation of blood vessel endothelial cell migration;GO:0045737|positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045840|positive regulation of mitotic nuclear division;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051496|positive regulation of stress fiber assembly;GO:0051726|regulation of cell cycle;GO:0071456|cellular response to hypoxia;GO:0072537|fibroblast activation;GO:0090272|negative regulation of fibroblast growth factor production;GO:1900087|positive regulation of G1/S transition of mitotic cell cycle;GO:1901203|positive regulation of extracellular matrix assembly;GO:1901991|negative regulation of mitotic cell cycle phase transition;GO:2000048|negative regulation of cell-cell adhesion mediated by cadherin;GO:2000353|positive regulation of endothelial cell apoptotic process;GO:2000573|positive regulation of DNA biosynthetic process;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005813|centrosome;","GO:0019901|protein kinase binding;GO:0030295|protein kinase activator activity;GO:0070412|R-SMAD binding;",".","."]
["ENSRNOG00000055567",4609,296.4989896,1839,118.7292599,2.497269753,1.320351669,{"v":3.5532e-267,"d":"3.55E-267"},{"v":5.8822e-266,"d":"5.88E-266"},"up","yes","Fmnl2","protein_coding","chr3:37348574-37624754:+","gi|589922793|ref|XP_006974299.1|",4834,0,"PREDICTED: formin-like protein 2 isoform X2 [Peromyscus maniculatus bairdii]","gi|755497909|ref|XM_006498335.2|",3241,0,"PREDICTED: Mus musculus formin-like 2 (Fmnl2), transcript variant X6, mRNA","A2APV2",1795,0,"Formin-like protein 2",".",".",".",".","pfam02181","FH2","Formin Homology 2 Domain.","GO:0007010|cytoskeleton organization;GO:0008360|regulation of cell shape;GO:0016477|cell migration;GO:0022604|regulation of cell morphogenesis;GO:0030866|cortical actin cytoskeleton organization;","GO:0005829|cytosol;","GO:0031267|small GTPase binding;GO:0051015|actin filament binding;","K23957","FMNL; formic-like protein"]
["ENSRNOG00000015279",1479,95.14471808,154,9.942526387,9.569471015,3.258439177,{"v":1.059E-266,"d":"1.06E-266"},{"v":1.7431e-265,"d":"1.74E-265"},"up","yes","Vtcn1","protein_coding","chr2:188253594-188321658:+","gi|66730411|ref|NP_001019415.1|",1294,{"v":4e-169,"d":"4.00E-169"},"V-set domain-containing T-cell activation inhibitor 1 precursor [Rattus norvegicus]","gi|66730410|ref|NM_001024244.1|",2619,0,"Rattus norvegicus V-set domain containing T cell activation inhibitor 1 (Vtcn1), mRNA","Q501W4",503,{"v":1e-170,"d":"1.00E-170"},"V-set domain-containing T-cell activation inhibitor 1",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0001562|response to protozoan;GO:0001817|regulation of cytokine production;GO:0002250|adaptive immune response;GO:0032743|positive regulation of interleukin-2 production;GO:0042102|positive regulation of T cell proliferation;GO:0042130|negative regulation of T cell proliferation;GO:0043066|negative regulation of apoptotic process;GO:0050852|T cell receptor signaling pathway;GO:0050868|negative regulation of T cell activation;","GO:0009897|external side of plasma membrane;GO:0031225|anchored component of membrane;","GO:0005102|signaling receptor binding;","K06747","B7H4, VTCN1; immune costimulatory protein B7-H4"]
["ENSRNOG00000014718",2659,171.0546351,696,44.93505432,3.806708097,1.928543947,{"v":2.5115e-266,"d":"2.51E-266"},{"v":4.1219E-265,"d":"4.12E-265"},"up","yes","Acsl3","protein_coding","chr9:80115112-80164627:+","gi|16923952|ref|NP_476448.1|",3855,0,"long-chain-fatty-acid--CoA ligase 3 [Rattus norvegicus]","gi|298904418|emb|FQ221868.1|",1761,0,"Rattus norvegicus TL0ADA30YL16 mRNA sequence","Q63151",1489,0,"Long-chain-fatty-acid--CoA ligase 3","SPBC18H10.02",352,{"v":2e-106,"d":"2.00E-106"},"COG1022","pfam00501","AMP-binding","AMP-binding enzyme.","GO:0001676|long-chain fatty acid metabolic process;GO:0006633|fatty acid biosynthetic process;GO:0007420|brain development;GO:0007584|response to nutrient;GO:0014070|response to organic cyclic compound;GO:0030182|neuron differentiation;GO:0034379|very-low-density lipoprotein particle assembly;GO:0035336|long-chain fatty-acyl-CoA metabolic process;GO:0042998|positive regulation of Golgi to plasma membrane protein transport;GO:0044539|long-chain fatty acid import;GO:0051047|positive regulation of secretion;GO:2001247|positive regulation of phosphatidylcholine biosynthetic process;","GO:0005575|cellular_component;GO:0005741|mitochondrial outer membrane;GO:0005778|peroxisomal membrane;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005794|Golgi apparatus;GO:0005811|lipid droplet;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0048471|perinuclear region of cytoplasm;","GO:0004467|long-chain fatty acid-CoA ligase activity;GO:0005524|ATP binding;GO:0019901|protein kinase binding;GO:0019904|protein domain specific binding;GO:0047676|arachidonate-CoA ligase activity;","K01897","ACSL, fadD; long-chain acyl-CoA synthetase [EC:6.2.1.3]"]
["ENSRNOG00000053577",3035,195.2428799,900,58.10567369,3.360134519,1.748518991,{"v":5.6039E-266,"d":"5.60E-266"},{"v":9.1444E-265,"d":"9.14E-265"},"up","yes","Gramd1b","protein_coding","chr8:40659182-40893925:-","gi|961738120|ref|XP_014929585.1|",3747,0,"PREDICTED: GRAM domain-containing protein 1B isoform X2 [Acinonyx jubatus]","gi|672061522|ref|XM_008766118.1|",2301,0,"PREDICTED: Rattus norvegicus GRAM domain containing 1B (Gramd1b), transcript variant X4, mRNA","Q80TI0",1428,0,"GRAM domain-containing protein 1B",".",".",".",".","pfam02893","GRAM","GRAM domain. The GRAM domain is found in in glucosyltransferases, myotubularins and other putative membrane-associated proteins.","GO:0008150|biological_process;GO:0015918|sterol transport;GO:0042632|cholesterol homeostasis;GO:0071397|cellular response to cholesterol;GO:0120009|intermembrane lipid transfer;","GO:0005575|cellular_component;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0001786|phosphatidylserine binding;GO:0003674|molecular_function;GO:0015485|cholesterol binding;GO:0070300|phosphatidic acid binding;GO:0120020|intermembrane cholesterol transfer activity;",".","."]
["ENSRNOG00000002722",4293,276.1705711,1645,106.2042591,2.6003719,1.378717969,{"v":6.4354e-266,"d":"6.44E-266"},{"v":1.0471E-264,"d":"1.05E-264"},"up","yes","Sec14l1","protein_coding","chr10:102319920-102367068:+","gi|157819695|ref|NP_001101779.1|",3678,0,"SEC14-like protein 1 [Rattus norvegicus]","gi|157819694|ref|NM_001108309.1|",2265,0,"Rattus norvegicus SEC14-like lipid binding 1 (Sec14l1), mRNA","A8Y5H7",1394,0,"SEC14-like protein 1",".",".",".",".","pfam04707","PRELI","PRELI-like family. This family includes a conserved region found in the PRELI protein and yeast YLR168C gene MSF1 product. The function of this protein is unknown, though it is thought to be involved in intra-mitochondrial protein sorting. This region is also found in a number of other eukaryotic proteins.","GO:0015871|choline transport;GO:0039536|negative regulation of RIG-I signaling pathway;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005829|cytosol;","GO:0039552|RIG-I binding;",".","."]
["ENSRNOG00000019466",2360,151.8198341,547,35.31533723,4.298977329,2.103993502,{"v":9.3571e-265,"d":"9.36E-265"},{"v":1.5139E-263,"d":"1.51E-263"},"up","yes","Agpat2","protein_coding","chr3:9416843-9428371:-","gi|157822109|ref|NP_001101291.1|",1287,{"v":6e-174,"d":"6.00E-174"},"1-acyl-sn-glycerol-3-phosphate acyltransferase beta precursor [Rattus norvegicus]","gi|449784894|ref|NM_026212.2|",947,0,"Mus musculus 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) (Agpat2), mRNA","Q8K3K7",487,{"v":2E-170,"d":"2.00E-170"},"1-acyl-sn-glycerol-3-phosphate acyltransferase beta","SPAC1851.02",113,{"v":2e-27,"d":"2.00E-27"},"COG0204","pfam01553","Acyltransferase","Acyltransferase. This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.","GO:0001819|positive regulation of cytokine production;GO:0006654|phosphatidic acid biosynthetic process;GO:0008544|epidermis development;GO:0009410|response to xenobiotic stimulus;","GO:0005575|cellular_component;GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0003841|1-acylglycerol-3-phosphate O-acyltransferase activity;","K13509","AGPAT1_2; lysophosphatidate acyltransferase [EC:2.3.1.51]"]
["ENSRNOG00000027847",3198,205.7287413,1005,64.88466895,3.170683378,1.664793818,{"v":1.3888E-261,"d":"1.39E-261"},{"v":2.2281e-260,"d":"2.23E-260"},"up","yes","Nxpe2","protein_coding","chr8:48661708-48698035:-","gi|149041573|gb|EDL95414.1|",2880,0,"rCG58102, isoform CRA_b [Rattus norvegicus]","gi|672022774|ref|XM_003754424.3|",3044,0,"PREDICTED: Rattus norvegicus neurexophilin and PC-esterase domain family, member 2 (Nxpe2), transcript variant X1, mRNA","Q3U095",961,0,"NXPE family member 2",".",".",".",".","pfam06312","Neurexophilin","Neurexophilin. This family consists of mammalian neurexophilin proteins. Mammalian brains contain four different neurexophilin proteins. Neurexophilins form a family of related glycoproteins that are proteolytically processed after synthesis and bind to alpha-neurexins. The structure and characteristics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000006709",1160,74.62330829,49,3.163531123,23.58861203,4.560018627,{"v":5.6896e-261,"d":"5.69E-261"},{"v":9.1022e-260,"d":"9.10E-260"},"up","yes","Pzp","protein_coding","chr4:161759182-161805276:-","gi|307746876|ref|NP_665722.2|",7768,0,"alpha-1-macroglobulin precursor [Rattus norvegicus]","gi|307746875|ref|NM_145779.2|",2925,0,"Rattus norvegicus pregnancy-zone protein (Pzp), mRNA","Q63041",2972,0,"Alpha-1-macroglobulin","TM0984",84,{"v":3e-15,"d":"3.00E-15"},"COG2373","pfam07678","A2M_comp","A-macroglobulin complement component. This family includes the complement components region of the alpha-2-macroglobulin family.","GO:0007566|embryo implantation;GO:0010951|negative regulation of endopeptidase activity;","GO:0005615|extracellular space;","GO:0002020|protease binding;GO:0004866|endopeptidase inhibitor activity;GO:0004867|serine-type endopeptidase inhibitor activity;GO:0044877|protein-containing complex binding;GO:0048403|brain-derived neurotrophic factor binding;GO:0048406|nerve growth factor binding;","K23589","PZP; pregnancy zone protein"]
["ENSRNOG00000018044",3837,246.8358913,1391,89.80554678,2.748559528,1.458675726,{"v":8.0659e-259,"d":"8.07E-259"},{"v":1.2796E-257,"d":"1.28E-257"},"up","yes","Phyh","protein_coding","chr17:73329082-73346409:-","gi|16758486|ref|NP_446126.1|",1842,0,"phytanoyl-CoA dioxygenase, peroxisomal precursor [Rattus norvegicus]","gi|55824681|gb|BC086573.1|",1215,0,"Rattus norvegicus phytanoyl-CoA 2-hydroxylase, mRNA (cDNA clone MGC:105364 IMAGE:7306754), complete cds","P57093",714,0,"Phytanoyl-CoA dioxygenase, peroxisomal","all4427",77.8,{"v":6e-15,"d":"6.00E-15"},"COG5285","pfam05721","PhyH","Phytanoyl-CoA dioxygenase (PhyH). This family is made up of several eukaryotic phytanoyl-CoA dioxygenase (PhyH) proteins, ectoine hydroxylases and a number of bacterial deoxygenases. PhyH is a peroxisomal enzyme catalyzing the first step of phytanic acid alpha-oxidation. PhyH deficiency causes Refsum's disease (RD) which is an inherited neurological syndrome biochemically characterized by the accumulation of phytanic acid in plasma and tissues.","GO:0001561|fatty acid alpha-oxidation;GO:0006103|2-oxoglutarate metabolic process;GO:0006720|isoprenoid metabolic process;GO:0019606|2-oxobutyrate catabolic process;GO:0097089|methyl-branched fatty acid metabolic process;","GO:0005739|mitochondrion;GO:0005777|peroxisome;GO:0097731|9+0 non-motile cilium;","GO:0003824|catalytic activity;GO:0008198|ferrous iron binding;GO:0031406|carboxylic acid binding;GO:0031418|L-ascorbic acid binding;GO:0048244|phytanoyl-CoA dioxygenase activity;","K00477","PHYH; phytanoyl-CoA hydroxylase [EC:1.14.11.18]"]
["ENSRNOG00000006859",2747,176.7157137,765,49.38982264,3.577978301,1.839144638,{"v":3.6425E-258,"d":"3.64E-258"},{"v":5.7628e-257,"d":"5.76E-257"},"up","yes","Insig1","protein_coding","chr4:7315495-7323952:-","gi|11693162|ref|NP_071787.1|",1099,{"v":4e-140,"d":"4.00E-140"},"insulin-induced gene 1 protein [Rattus norvegicus]","gi|50925490|gb|BC078827.1|",2446,0,"Rattus norvegicus insulin induced gene 1, mRNA (cDNA clone MGC:93442 IMAGE:7125208), complete cds","Q08755",427,{"v":1E-141,"d":"1.00E-141"},"Insulin-induced gene 1 protein",".",".",".",".","pfam07281","INSIG","Insulin-induced protein (INSIG). This family contains a number of eukaryotic Insulin-induced proteins (INSIG-1 and INSIG-2) approximately 200 residues long. INSIG-1 and INSIG-2 are found in the endoplasmic reticulum and bind the sterol-sensing domain of SREBP cleavage-activating protein (SCAP), preventing it from escorting SREBPs to the Golgi. Their combined action permits feedback regulation of cholesterol synthesis over a wide range of sterol concentrations.","GO:0006641|triglyceride metabolic process;GO:0006695|cholesterol biosynthetic process;GO:0006991|response to sterol depletion;GO:0008203|cholesterol metabolic process;GO:0010894|negative regulation of steroid biosynthetic process;GO:0016126|sterol biosynthetic process;GO:0032355|response to estradiol;GO:0032869|cellular response to insulin stimulus;GO:0032933|SREBP signaling pathway;GO:0033993|response to lipid;GO:0036315|cellular response to sterol;GO:0036316|SREBP-SCAP complex retention in endoplasmic reticulum;GO:0042472|inner ear morphogenesis;GO:0042474|middle ear morphogenesis;GO:0042632|cholesterol homeostasis;GO:0043434|response to peptide hormone;GO:0045599|negative regulation of fat cell differentiation;GO:0045717|negative regulation of fatty acid biosynthetic process;GO:0060021|roof of mouth development;GO:0060363|cranial suture morphogenesis;GO:0070542|response to fatty acid;GO:0070862|negative regulation of protein exit from endoplasmic reticulum;GO:1901303|negative regulation of cargo loading into COPII-coated vesicle;","GO:0005575|cellular_component;GO:0005783|endoplasmic reticulum;GO:0032937|SREBP-SCAP-Insig complex;","GO:0003674|molecular_function;GO:0008142|oxysterol binding;",".","."]
["ENSRNOG00000001442",3640,234.162795,1275,82.31637106,2.844668588,1.508260584,{"v":4.867e-258,"d":"4.87E-258"},{"v":7.6787e-257,"d":"7.68E-257"},"up","yes","Por","protein_coding","chr12:20951058-20999245:-","gi|13928780|ref|NP_113764.1|",3576,0,"NADPH--cytochrome P450 reductase [Rattus norvegicus]","gi|13928779|ref|NM_031576.1|",2428,0,"Rattus norvegicus P450 (cytochrome) oxidoreductase (Por), mRNA","P00388",1382,0,"NADPH--cytochrome P450 reductase","SPBC365.17",347,{"v":3e-106,"d":"3.00E-106"},"COG0369","pfam00667","FAD_binding_1","FAD binding domain. This domain is found in sulfite reductase, NADPH cytochrome P450 reductase, Nitric oxide synthase and methionine synthase reductase.","GO:0003420|regulation of growth plate cartilage chondrocyte proliferation;GO:0007584|response to nutrient;GO:0009410|response to xenobiotic stimulus;GO:0009437|carnitine metabolic process;GO:0009725|response to hormone;GO:0009812|flavonoid metabolic process;GO:0018393|internal peptidyl-lysine acetylation;GO:0019395|fatty acid oxidation;GO:0022900|electron transport chain;GO:0032332|positive regulation of chondrocyte differentiation;GO:0032770|positive regulation of monooxygenase activity;GO:0043066|negative regulation of apoptotic process;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043602|nitrate catabolic process;GO:0045542|positive regulation of cholesterol biosynthetic process;GO:0045880|positive regulation of smoothened signaling pathway;GO:0046210|nitric oxide catabolic process;GO:0060192|negative regulation of lipase activity;GO:0070988|demethylation;GO:0071371|cellular response to gonadotropin stimulus;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0071375|cellular response to peptide hormone stimulus;GO:0071548|response to dexamethasone;GO:0090031|positive regulation of steroid hormone biosynthetic process;GO:0090181|regulation of cholesterol metabolic process;GO:0090346|cellular organofluorine metabolic process;","GO:0005739|mitochondrion;GO:0005789|endoplasmic reticulum membrane;GO:0005829|cytosol;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0003958|NADPH-hemoprotein reductase activity;GO:0004128|cytochrome-b5 reductase activity, acting on NAD(P)H;GO:0008941|nitric oxide dioxygenase activity;GO:0009055|electron transfer activity;GO:0010181|FMN binding;GO:0016491|oxidoreductase activity;GO:0016787|hydrolase activity;GO:0019899|enzyme binding;GO:0047726|iron-cytochrome-c reductase activity;GO:0050660|flavin adenine dinucleotide binding;GO:0050661|NADP binding;","K00327","POR; NADPH-ferrihemoprotein reductase [EC:1.6.2.4]"]
["ENSRNOG00000010311",3171,203.9918195,1003,64.75554523,3.150183027,1.655435652,{"v":2.4595e-257,"d":"2.46E-257"},{"v":3.8697e-256,"d":"3.87E-256"},"up","yes","Dzip1","protein_coding","chr15:95956398-96010066:-","gi|564318360|ref|XP_006222121.1|",4035,0,"PREDICTED: zinc finger protein DZIP1 isoform X3 [Rattus norvegicus]","gi|672028922|ref|XM_006222059.2|",3502,0,"PREDICTED: Rattus norvegicus DAZ interacting zinc finger protein 1 (Dzip1), transcript variant X3, mRNA","Q8BMD2",1359,0,"Zinc finger protein DZIP1",".",".",".",".","pfam13815","Dzip-like_N","Iguana/Dzip1-like DAZ-interacting protein N-terminal. The DAZ gene-product - Deleted in Azoospermia - and a closely related sequence are required early in germ-cell development in order to maintain germ-cell populations. This family is the N-terminal region that is the only part of the protein in some fungi and lower metazoa.","GO:0007224|smoothened signaling pathway;GO:0007281|germ cell development;GO:0007283|spermatogenesis;GO:0033365|protein localization to organelle;GO:0043393|regulation of protein binding;GO:0044782|cilium organization;GO:0045184|establishment of protein localization;GO:0045724|positive regulation of cilium assembly;GO:0051220|cytoplasmic sequestering of protein;GO:0060271|cilium assembly;GO:0061512|protein localization to cilium;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0005814|centriole;GO:0005829|cytosol;GO:0034451|centriolar satellite;GO:0036064|ciliary basal body;GO:0097539|ciliary transition fiber;",".","K16470","DZIP1; zinc finger protein DZIP1"]
["ENSRNOG00000005061",5091,327.5062608,2199,141.9715294,2.306844634,1.205920842,{"v":3.1031E-256,"d":"3.10E-256"},{"v":4.8423e-255,"d":"4.84E-255"},"up","yes","Dlst","protein_coding","chr6:104758631-104783296:+","gi|195927000|ref|NP_001006982.2|",1691,0,"dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial [Rattus norvegicus]","gi|672056484|ref|XM_008764756.1|",4053,0,"PREDICTED: Rattus norvegicus dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) (Dlst), transcript variant X2, mRNA","Q01205",647,0,"Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial","YDR148c",307,{"v":3e-91,"d":"3.00E-91"},"COG0508","pfam00198","2-oxoacid_dh","2-oxoacid dehydrogenases acyltransferase (catalytic domain). These proteins contain one to three copies of a lipoyl binding domain followed by the catalytic domain.","GO:0006099|tricarboxylic acid cycle;GO:0006103|2-oxoglutarate metabolic process;GO:0006104|succinyl-CoA metabolic process;GO:0006734|NADH metabolic process;GO:0033512|L-lysine catabolic process to acetyl-CoA via saccharopine;GO:0106077|histone succinylation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005739|mitochondrion;GO:0005759|mitochondrial matrix;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0034451|centriolar satellite;GO:0043231|intracellular membrane-bounded organelle;GO:0045252|oxoglutarate dehydrogenase complex;","GO:0004149|dihydrolipoyllysine-residue succinyltransferase activity;GO:0016746|transferase activity, transferring acyl groups;GO:0031072|heat shock protein binding;GO:0051087|chaperone binding;","K00658","DLST, sucB; 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61]"]
["ENSRNOG00000055925",5334,343.1385573,2362,152.4951125,2.250161016,1.170028241,{"v":6.8385e-256,"d":"6.84E-256"},{"v":1.0585e-254,"d":"1.06E-254"},"up","yes","Zc3h7b","protein_coding","chr7:113262165-113310399:+","gi|194733719|ref|NP_001124167.1|",4992,0,"zinc finger CCCH domain-containing protein 7B [Rattus norvegicus]","gi|194733718|ref|NM_001130695.1|",5434,0,"Rattus norvegicus zinc finger CCCH-type containing 7B (Zc3h7b), mRNA","Q9UGR2",1823,0,"Zinc finger CCCH domain-containing protein 7B","SPAC17A2.04c",70.1,{"v":2e-11,"d":"2.00E-11"},"COG0457","pfam13414","TPR_11","TPR repeat.","GO:0010608|posttranscriptional regulation of gene expression;GO:0035196|production of miRNAs involved in gene silencing by miRNA;",".","GO:0035198|miRNA binding;GO:0046872|metal ion binding;","K24945","ZC3H7; zinc finger CCCH domain-containing protein 7"]
["ENSRNOG00000012269",3434,220.9107247,1168,75.40825208,2.929529841,1.550669146,{"v":1.3431E-253,"d":"1.34E-253"},{"v":2.0566e-252,"d":"2.06E-252"},"up","yes","Lpcat3","protein_coding","chr4:157468290-157509880:+","gi|625183045|ref|XP_007645111.1|",2393,0,"PREDICTED: lysophospholipid acyltransferase 5 isoform X1 [Cricetulus griseus]","gi|58865949|ref|NM_001012189.1|",1895,0,"Rattus norvegicus lysophosphatidylcholine acyltransferase 3 (Lpcat3), mRNA","Q5FVN0",913,0,"Lysophospholipid acyltransferase 5","SPBC16A3.10",122,{"v":1e-28,"d":"1.00E-28"},"COG5202","pfam03062","MBOAT","MBOAT, membrane-bound O-acyltransferase family. The MBOAT (membrane bound O-acyl transferase) family of membrane proteins contains a variety of acyltransferase enzymes. A conserved histidine has been suggested to be the active site residue.","GO:0006656|phosphatidylcholine biosynthetic process;GO:0008150|biological_process;GO:0030258|lipid modification;GO:0034378|chylomicron assembly;GO:0034379|very-low-density lipoprotein particle assembly;GO:0036150|phosphatidylserine acyl-chain remodeling;GO:0036151|phosphatidylcholine acyl-chain remodeling;GO:0036152|phosphatidylethanolamine acyl-chain remodeling;GO:0036335|intestinal stem cell homeostasis;GO:0045540|regulation of cholesterol biosynthetic process;GO:0045797|positive regulation of intestinal cholesterol absorption;GO:0050728|negative regulation of inflammatory response;GO:0090158|endoplasmic reticulum membrane organization;GO:0097006|regulation of plasma lipoprotein particle levels;GO:1901310|positive regulation of sterol regulatory element binding protein cleavage;GO:1903573|negative regulation of response to endoplasmic reticulum stress;GO:1905885|positive regulation of triglyceride transport;","GO:0005575|cellular_component;GO:0005789|endoplasmic reticulum membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0016746|transferase activity, transferring acyl groups;GO:0047184|1-acylglycerophosphocholine O-acyltransferase activity;GO:0071617|lysophospholipid acyltransferase activity;","K13515","LPCAT3, MBOAT5; lysophospholipid acyltransferase 5 [EC:2.3.1.23 2.3.1.-]"]
["ENSRNOG00000014964",1683,108.2681275,262,16.91520723,6.400638549,2.67821584,{"v":7.9391E-251,"d":"7.94E-251"},{"v":1.2059e-249,"d":"1.21E-249"},"up","yes","Hp","protein_coding","chr19:37539627-37544523:-","gi|60097941|ref|NP_036714.2|",1859,0,"haptoglobin precursor [Rattus norvegicus]","gi|298903469|emb|FQ209684.1|",1180,0,"Rattus norvegicus TL0ABA41YC01 mRNA sequence","P06866",720,0,"Haptoglobin","mlr3307",54.3,8e-07,"COG5640","pfam00089","Trypsin","Trypsin.","GO:0001666|response to hypoxia;GO:0001889|liver development;GO:0002526|acute inflammatory response;GO:0006508|proteolysis;GO:0006953|acute-phase response;GO:0007219|Notch signaling pathway;GO:0007283|spermatogenesis;GO:0007568|aging;GO:0009408|response to heat;GO:0009410|response to xenobiotic stimulus;GO:0009617|response to bacterium;GO:0010033|response to organic substance;GO:0010165|response to X-ray;GO:0010288|response to lead ion;GO:0010942|positive regulation of cell death;GO:0014070|response to organic cyclic compound;GO:0031100|animal organ regeneration;GO:0031638|zymogen activation;GO:0032026|response to magnesium ion;GO:0032496|response to lipopolysaccharide;GO:0033590|response to cobalamin;GO:0033591|response to L-ascorbic acid;GO:0042542|response to hydrogen peroxide;GO:0042594|response to starvation;GO:0042742|defense response to bacterium;GO:0051354|negative regulation of oxidoreductase activity;GO:0051384|response to glucocorticoid;GO:0051602|response to electrical stimulus;GO:0060416|response to growth hormone;GO:0098869|cellular oxidant detoxification;GO:2000296|negative regulation of hydrogen peroxide catabolic process;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0031838|haptoglobin-hemoglobin complex;GO:0072562|blood microparticle;","GO:0004252|serine-type endopeptidase activity;GO:0016209|antioxidant activity;GO:0030492|hemoglobin binding;GO:0042802|identical protein binding;","K16142","HP; haptoglobin"]
["ENSRNOG00000005406",5529,355.6829927,2524,162.9541338,2.18271844,1.126126042,{"v":1.5425e-249,"d":"1.54E-249"},{"v":2.3367e-248,"d":"2.34E-248"},"up","yes","Clint1","protein_coding","chr10:30298704-30353063:+","gi|672067331|ref|XP_008765910.1|",2566,0,"PREDICTED: clathrin interactor 1 isoform X2 [Rattus norvegicus]","gi|672067330|ref|XM_008767688.1|",5797,0,"PREDICTED: Rattus norvegicus clathrin interactor 1 (Clint1), transcript variant X2, mRNA","Q99KN9",916,0,"Clathrin interactor 1",".",".",".",".","pfam01417","ENTH","ENTH domain. The ENTH (Epsin N-terminal homology) domain is found in proteins involved in endocytosis and cytoskeletal machinery. The function of the ENTH domain is unknown.","GO:0006897|endocytosis;GO:0048268|clathrin coat assembly;","GO:0005654|nucleoplasm;GO:0005768|endosome;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0030125|clathrin vesicle coat;GO:0030136|clathrin-coated vesicle;GO:0043231|intracellular membrane-bounded organelle;","GO:0005543|phospholipid binding;GO:0030276|clathrin binding;","K24721","CLINT1, EPN4; clathrin interactor 1"]
["ENSRNOG00000019949",1893,121.7775195,359,23.17770762,5.254079545,2.393438043,{"v":1.0389E-248,"d":"1.04E-248"},{"v":1.5656e-247,"d":"1.57E-247"},"up","yes","Mrps12","protein_coding","chr1:84025899-84028780:-","gi|157819713|ref|NP_001099709.1|",722,{"v":2e-93,"d":"2.00E-93"},"28S ribosomal protein S12, mitochondrial [Rattus norvegicus]","gi|564327094|ref|XM_006228651.1|",793,0,"PREDICTED: Rattus norvegicus mitochondrial ribosomal protein S12 (Mrps12), transcript variant X2, mRNA","O35680",273,{"v":5E-91,"d":"5.00E-91"},"28S ribosomal protein S12, mitochondrial","FN1558",117,{"v":3e-31,"d":"3.00E-31"},"COG0048","pfam00164","Ribosom_S12_S23","Ribosomal protein S12/S23. This protein is known as S12 in bacteria and archaea and S23 in eukaryotes.","GO:0006412|translation;","GO:0005763|mitochondrial small ribosomal subunit;GO:0005840|ribosome;","GO:0003735|structural constituent of ribosome;","K02950","RP-S12, MRPS12, rpsL; small subunit ribosomal protein S12"]
["ENSRNOG00000042560",2220,142.8135728,524,33.83041446,4.221455015,2.07774034,{"v":2.988e-245,"d":"2.99E-245"},{"v":4.4673e-244,"d":"4.47E-244"},"up","yes","Bag4","protein_coding","chr16:66288678-66308663:+","gi|68341993|ref|NP_001020301.1|",1287,{"v":1e-158,"d":"1.00E-158"},"BAG family molecular chaperone regulator 4 [Rattus norvegicus]","gi|116686110|ref|NM_026121.3|",2550,0,"Mus musculus BCL2-associated athanogene 4 (Bag4), mRNA","Q8CI61",442,{"v":8e-139,"d":"8.00E-139"},"BAG family molecular chaperone regulator 4",".",".",".",".","pfam02179","BAG","BAG domain. Domain present in Hsp70 regulators.",".",".",".",".","."]
["ENSRNOG00000036693",2295,147.6383556,564,36.41288885,4.054563104,2.019546467,{"v":2.0181e-244,"d":"2.02E-244"},{"v":3.0015e-243,"d":"3.00E-243"},"up","yes","Slc25a10","protein_coding","chr10:105765372-105773556:+","gi|19173788|ref|NP_596909.1|",1361,{"v":3e-177,"d":"3.00E-177"},"mitochondrial dicarboxylate carrier [Rattus norvegicus]","gi|51859427|gb|BC081734.1|",1801,0,"Rattus norvegicus solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10, mRNA (cDNA clone MGC:93224 IMAGE:7108552), complete cds","Q9QZD8",514,{"v":5e-173,"d":"5.00E-173"},"Mitochondrial dicarboxylate carrier",".",".",".",".","pfam00153","Mito_carr","Mitochondrial carrier protein.","GO:0006817|phosphate ion transport;GO:0006839|mitochondrial transport;GO:0008272|sulfate transport;GO:0015709|thiosulfate transport;GO:0015729|oxaloacetate transport;GO:0015743|malate transport;GO:0015744|succinate transport;GO:0035435|phosphate ion transmembrane transport;GO:0071422|succinate transmembrane transport;GO:0071423|malate transmembrane transport;GO:1902356|oxaloacetate(2-) transmembrane transport;GO:1902358|sulfate transmembrane transport;","GO:0005654|nucleoplasm;GO:0005739|mitochondrion;GO:0016021|integral component of membrane;GO:0031966|mitochondrial membrane;","GO:0015114|phosphate ion transmembrane transporter activity;GO:0015116|sulfate transmembrane transporter activity;GO:0015117|thiosulfate transmembrane transporter activity;GO:0015131|oxaloacetate transmembrane transporter activity;GO:0015140|malate transmembrane transporter activity;GO:0015141|succinate transmembrane transporter activity;GO:0015291|secondary active transmembrane transporter activity;GO:0015297|antiporter activity;","K13577","SLC25A10, DIC; solute carrier family 25 (mitochondrial dicarboxylate transporter), member 10"]
["ENSRNOG00000068887",4066,261.5675617,1611,104.0091559,2.514851307,1.330473102,{"v":1.0321E-238,"d":"1.03E-238"},{"v":1.5193E-237,"d":"1.52E-237"},"up","yes","Ddt","protein_coding","chr20:12884243-12888482:+","gi|13162287|ref|NP_077045.1|",618,{"v":1e-72,"d":"1.00E-72"},"D-dopachrome decarboxylase [Rattus norvegicus]","gi|298916751|emb|FQ210467.1|",585,0,"Rattus norvegicus TL0ABA28YC08 mRNA sequence","P80254",242,{"v":5E-74,"d":"5.00E-74"},"D-dopachrome decarboxylase",".",".",".",".","pfam01187","MIF","Macrophage migration inhibitory factor (MIF).",".",".",".",".","."]
["ENSRNOG00000001607",3916,251.9179959,1539,99.36070201,2.535388648,1.342206914,{"v":4.4425e-233,"d":"4.44E-233"},{"v":6.4725e-232,"d":"6.47E-232"},"up","yes","Adamts1","protein_coding","chr11:24931761-24941103:-","gi|148747506|ref|NP_077376.2|",5000,0,"A disintegrin and metalloproteinase with thrombospondin motifs 1 precursor [Rattus norvegicus]","gi|4929477|gb|AF149118.1|AF149118",4783,0,"Rattus norvegicus a disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS-1) mRNA, complete cds","Q9WUQ1",1927,0,"A disintegrin and metalloproteinase with thrombospondin motifs 1",".",".",".",".","pfam05986","ADAM_spacer1","ADAM-TS Spacer 1. This family represents the Spacer-1 region from the ADAM-TS family of metalloproteinases.","GO:0001542|ovulation from ovarian follicle;GO:0001822|kidney development;GO:0006508|proteolysis;GO:0007229|integrin-mediated signaling pathway;GO:0010976|positive regulation of neuron projection development;GO:0016525|negative regulation of angiogenesis;GO:0030198|extracellular matrix organization;GO:0030728|ovulation;GO:0044691|tooth eruption;GO:0060347|heart trabecula formation;GO:0071305|cellular response to vitamin D;GO:0071374|cellular response to parathyroid hormone stimulus;GO:0071380|cellular response to prostaglandin E stimulus;GO:1900087|positive regulation of G1/S transition of mitotic cell cycle;GO:1904707|positive regulation of vascular smooth muscle cell proliferation;GO:1904754|positive regulation of vascular associated smooth muscle cell migration;","GO:0005576|extracellular region;GO:0005604|basement membrane;GO:0031012|extracellular matrix;GO:0031410|cytoplasmic vesicle;GO:0062023|collagen-containing extracellular matrix;","GO:0003674|molecular_function;GO:0004222|metalloendopeptidase activity;GO:0008201|heparin binding;GO:0008270|zinc ion binding;","K08617","ADAMTS1; a disintegrin and metalloproteinase with thrombospondin motifs 1 [EC:3.4.24.-]"]
["ENSRNOG00000000186",2306,148.3459905,599,38.67255393,3.835950186,1.939583986,{"v":5.3719e-233,"d":"5.37E-233"},{"v":7.8068e-232,"d":"7.81E-232"},"up","yes","Tst","protein_coding","chr7:109948062-109957216:-","gi|57528682|ref|NP_036940.1|",1599,0,"thiosulfate sulfurtransferase [Rattus norvegicus]","gi|298882732|emb|FQ211117.1|",1089,0,"Rattus norvegicus TL0ABA17YD14 mRNA sequence","P24329",620,0,"Thiosulfate sulfurtransferase","BMEI0931",224,{"v":3e-66,"d":"3.00E-66"},"COG2897","pfam00581","Rhodanese","Rhodanese-like domain. Rhodanese has an internal duplication. This Pfam represents a single copy of this duplicated domain. The domain is found as a single copy in other proteins, including phosphatases and ubiquitin C-terminal hydrolases.","GO:0016226|iron-sulfur cluster assembly;GO:0019346|transsulfuration;GO:0030855|epithelial cell differentiation;GO:0035928|rRNA import into mitochondrion;GO:0051029|rRNA transport;","GO:0005739|mitochondrion;GO:0005759|mitochondrial matrix;","GO:0004792|thiosulfate sulfurtransferase activity;GO:0008097|5S rRNA binding;GO:0016783|sulfurtransferase activity;","K01011","TST, MPST, sseA; thiosulfate/3-mercaptopyruvate sulfurtransferase [EC:2.8.1.1 2.8.1.2]"]
["ENSRNOG00000018602",2420,155.6796604,662,42.73995109,3.642485694,1.864923306,{"v":5.4638e-232,"d":"5.46E-232"},{"v":7.8802E-231,"d":"7.88E-231"},"up","yes","Camta1","protein_coding","chr5:161510283-162356723:-","gi|307133744|ref|NP_001182488.1|",8450,0,"calmodulin-binding transcription activator 1 isoform 1 [Rattus norvegicus]","gi|307133743|ref|NM_001195559.1|",8460,0,"Rattus norvegicus calmodulin binding transcription activator 1 (Camta1), transcript variant 1, mRNA","A2A891",3160,0,"Calmodulin-binding transcription activator 1",".",".",".",".","pfam03859","CG-1","CG-1 domain. CG-1 domains are highly conserved domains of about 130 amino-acid residues containing a predicted bipartite NLS and named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs.","GO:0035307|positive regulation of protein dephosphorylation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050885|neuromuscular process controlling balance;GO:0070886|positive regulation of calcineurin-NFAT signaling cascade;","GO:0005730|nucleolus;GO:0005829|cytosol;","GO:0043565|sequence-specific DNA binding;","K21596","CAMTA; calmodulin-binding transcription activator"]
["ENSRNOG00000005176",1559,100.2911531,245,15.81765562,6.340456232,2.664586654,{"v":3.0416e-231,"d":"3.04E-231"},{"v":4.3756e-230,"d":"4.38E-230"},"up","yes","ENSRNOG00000005176","protein_coding","chrX:35372700-35488091:-","gi|576796148|ref|NP_001276707.1|",1599,0,"MAP7 domain-containing protein 2 [Rattus norvegicus]","gi|298913449|emb|FQ214474.1|",2333,0,"Rattus norvegicus TL0AAA41YI02 mRNA sequence","A2AG50",526,{"v":6e-168,"d":"6.00E-168"},"MAP7 domain-containing protein 2",".",".",".",".","pfam05672","MAP7","MAP7 (E-MAP-115) family. The organisation of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilizing protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.","GO:0000226|microtubule cytoskeleton organization;","GO:0015630|microtubule cytoskeleton;",".","K24203","MAP7D2; MAP7 domain-containing protein 2"]
["ENSRNOG00000012156",4479,288.1360326,1910,123.3131519,2.33662045,1.224423409,{"v":4.0254e-231,"d":"4.03E-231"},{"v":5.7764e-230,"d":"5.78E-230"},"up","yes","Ostf1","protein_coding","chr1:216002044-216049221:-","gi|354501350|ref|XP_003512755.1|",601,{"v":4E-70,"d":"4.00E-70"},"PREDICTED: osteoclast-stimulating factor 1 isoform X1 [Cricetulus griseus]","gi|672039917|ref|XM_008760287.1|",729,0,"PREDICTED: Rattus norvegicus osteoclast stimulating factor 1 (Ostf1), transcript variant X1, mRNA","Q6P686",236,{"v":2e-71,"d":"2.00E-71"},"Osteoclast-stimulating factor 1",".",".",".",".","pfam14604","SH3_9","Variant SH3 domain.","GO:0007165|signal transduction;","GO:0005737|cytoplasm;","GO:0017124|SH3 domain binding;",".","."]
["ENSRNOG00000062361",4502,289.6156327,1938,125.120884,2.314686593,1.210816867,{"v":2.8303E-228,"d":"2.83E-228"},{"v":4.0012e-227,"d":"4.00E-227"},"up","yes","ENSRNOG00000062361","lncRNA","chr13:13274746-13276098:-","gi|149027698|gb|EDL83221.1|",190,{"v":3e-14,"d":"3.00E-14"},"rCG29124 [Rattus norvegicus]","gi|241982901|gb|AC136178.3|",1185,0,"Rattus norvegicus CH230-435P16 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P31794",45.1,{"v":9e-11,"d":"9.00E-11"},"Envelope glycoprotein",".",".",".",".","pfam00429","TLV_coat","ENV polyprotein (coat polyprotein).",".",".",".",".","."]
["ENSRNOG00000019830",5416,348.4136532,2564,165.5366082,2.104752883,1.073650858,{"v":1.8289e-226,"d":"1.83E-226"},{"v":2.5728e-225,"d":"2.57E-225"},"up","yes","Hsd17b1","protein_coding","chr10:86009728-86011927:+","gi|6981048|ref|NP_036983.1|",1809,0,"estradiol 17-beta-dehydrogenase 1 [Rattus norvegicus]","gi|402693121|ref|NM_012851.2|",1418,0,"Rattus norvegicus hydroxysteroid (17-beta) dehydrogenase 1 (Hsd17b1), mRNA","P51657",701,0,"Estradiol 17-beta-dehydrogenase 1","CAC3335",122,{"v":1e-30,"d":"1.00E-30"},"COG1028","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.","GO:0006703|estrogen biosynthetic process;GO:0060348|bone development;GO:0061370|testosterone biosynthetic process;GO:0071248|cellular response to metal ion;","GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004303|estradiol 17-beta-dehydrogenase activity;GO:0005496|steroid binding;GO:0030283|testosterone dehydrogenase [NAD(P)] activity;GO:0042803|protein homodimerization activity;GO:0044594|17-beta-hydroxysteroid dehydrogenase (NAD+) activity;GO:0047035|testosterone dehydrogenase (NAD+) activity;GO:0050661|NADP binding;GO:0070401|NADP+ binding;GO:0072582|17-beta-hydroxysteroid dehydrogenase (NADP+) activity;GO:1903924|estradiol binding;","K00044","HSD17B1; 17beta-estradiol 17-dehydrogenase [EC:1.1.1.62]"]
["ENSRNOG00000001113",2060,132.5207027,491,31.69987309,4.180480543,2.063668788,{"v":9.0489e-226,"d":"9.05E-226"},{"v":1.2698e-224,"d":"1.27E-224"},"up","yes","Mmd2","protein_coding","chr12:11962757-12009773:+","gi|82617612|ref|NP_001032294.1|",1317,{"v":3E-175,"d":"3.00E-175"},"monocyte to macrophage differentiation factor 2 [Rattus norvegicus]","gi|82617611|ref|NM_001037217.1|",2133,0,"Rattus norvegicus monocyte to macrophage differentiation-associated 2 (Mmd2), mRNA","Q8R189",508,{"v":2E-175,"d":"2.00E-175"},"Monocyte to macrophage differentiation factor 2","VC0040",96.3,{"v":3e-21,"d":"3.00E-21"},"COG1272","pfam03006","HlyIII","Haemolysin-III related. Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolizm. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea.","GO:0006468|protein phosphorylation;GO:0019835|cytolysis;GO:0032880|regulation of protein localization;GO:0045666|positive regulation of neuron differentiation;GO:0045860|positive regulation of protein kinase activity;GO:0046579|positive regulation of Ras protein signal transduction;","GO:0016021|integral component of membrane;GO:0048471|perinuclear region of cytoplasm;","GO:0004672|protein kinase activity;","K11064","MMD; monocyte to macrophage differentiation protein"]
["ENSRNOG00000067387",1899,122.1635021,412,26.59948618,4.592701577,2.199343044,{"v":1.5622e-225,"d":"1.56E-225"},{"v":2.1761e-224,"d":"2.18E-224"},"up","yes","Sbk1","protein_coding","chr1:180807099-180851885:+","gi|674034618|ref|XP_008839815.1|",1805,0,"PREDICTED: serine/threonine-protein kinase SBK1 [Nannospalax galili]","gi|672034849|ref|XM_008758862.1|",3603,0,"PREDICTED: Rattus norvegicus serine/threonine-protein kinase SBK1 (LOC103690016), transcript variant X1, mRNA","Q9Z335",677,0,"Serine/threonine-protein kinase SBK1",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.",".",".",".",".","."]
["ENSRNOG00000020167",5361,344.8754791,2534,163.5997524,2.108044017,1.075904991,{"v":6.0501e-225,"d":"6.05E-225"},{"v":8.4073e-224,"d":"8.41E-224"},"up","yes","Reep5","protein_coding","chr18:25945381-25976509:-","gi|270288782|ref|NP_001102358.2|",818,{"v":2E-99,"d":"2.00E-99"},"receptor expression-enhancing protein 5 [Rattus norvegicus]","gi|270288781|ref|NM_001108888.2|",2807,0,"Rattus norvegicus receptor accessory protein 5 (Reep5), mRNA","B2RZ37",319,{"v":7e-101,"d":"7.00E-101"},"Receptor expression-enhancing protein 5","SPCC830.08c",110,{"v":5e-26,"d":"5.00E-26"},"COG5052","pfam03134","TB2_DP1_HVA22","TB2/DP1, HVA22 family. This family includes members from a wide variety of eukaryotes. It includes the TB2/DP1 (deleted in polyposis) protein, which in humans is deleted in severe forms of familial adenomatous polyposis, an autosomal dominant oncological inherited disease. The family also includes the plant protein of known similarity to TB2/DP1, the HVA22 abscisic acid-induced protein, which is thought to be a regulatory protein.",".","GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;GO:0071782|endoplasmic reticulum tubular network;",".","K17279","REEP5_6; receptor expression-enhancing protein 5/6"]
["ENSRNOG00000010797",1028,66.13169045,53,3.421778562,19.3267008,4.272523475,{"v":1.3301E-224,"d":"1.33E-224"},{"v":1.8438e-223,"d":"1.84E-223"},"up","yes","Esm1","protein_coding","chr2:44876067-44884804:+","gi|12018274|ref|NP_072126.1|",889,{"v":4e-112,"d":"4.00E-112"},"endothelial cell-specific molecule 1 precursor [Rattus norvegicus]","gi|47575857|ref|NM_022604.2|",2084,0,"Rattus norvegicus endothelial cell-specific molecule 1 (Esm1), mRNA","P97682",347,{"v":1e-113,"d":"1.00E-113"},"Endothelial cell-specific molecule 1",".",".",".",".","pfam00219","IGFBP","Insulin-like growth factor binding protein.","GO:0001525|angiogenesis;GO:0002040|sprouting angiogenesis;GO:0008284|positive regulation of cell proliferation;GO:1902204|positive regulation of hepatocyte growth factor receptor signaling pathway;","GO:0005576|extracellular region;","GO:0005171|hepatocyte growth factor receptor binding;GO:0005178|integrin binding;GO:0005520|insulin-like growth factor binding;","K25036","ESM1; endothelial cell-specific molecule 1"]
["ENSRNOG00000007682",2841,182.7627749,919,59.33234902,3.080322588,1.623081446,{"v":2.1084E-224,"d":"2.11E-224"},{"v":2.9156e-223,"d":"2.92E-223"},"up","yes","ENSRNOG00000007682","protein_coding","chrX:120238534-120504096:+","gi|60360568|dbj|BAD90527.1|",4554,0,"mKIAA4184 protein [Mus musculus]","gi|163792202|ref|NM_032990.2|",5024,0,"Rattus norvegicus glutamate ionotropic receptor AMPA type subunit 3 (Gria3), transcript variant 1, mRNA","Q9Z2W9",1725,0,"Glutamate receptor 3",".",".",".",".","pfam00060","Lig_chan","Ligand-gated ion channel. This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.","GO:0001919|regulation of receptor recycling;GO:0010226|response to lithium ion;GO:0034220|ion transmembrane transport;GO:0035235|ionotropic glutamate receptor signaling pathway;GO:0060078|regulation of postsynaptic membrane potential;GO:0060992|response to fungicide;","GO:0005886|plasma membrane;GO:0008328|ionotropic glutamate receptor complex;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0032279|asymmetric synapse;GO:0032281|AMPA glutamate receptor complex;GO:0032991|protein-containing complex;GO:0043025|neuronal cell body;GO:0043083|synaptic cleft;GO:0043195|terminal bouton;GO:0043197|dendritic spine;GO:0043198|dendritic shaft;GO:0043204|perikaryon;GO:0045211|postsynaptic membrane;GO:0098688|parallel fiber to Purkinje cell synapse;GO:0098978|glutamatergic synapse;GO:0099055|integral component of postsynaptic membrane;GO:0099056|integral component of presynaptic membrane;GO:0099061|integral component of postsynaptic density membrane;","GO:0001540|amyloid-beta binding;GO:0004970|ionotropic glutamate receptor activity;GO:0004971|AMPA glutamate receptor activity;GO:0005515|protein binding;GO:0015276|ligand-gated ion channel activity;GO:0030165|PDZ domain binding;GO:0038023|signaling receptor activity;GO:1904315|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K05199","GRIA3; glutamate receptor 3"]
["ENSRNOG00000017212",5605,360.572106,2712,175.0917634,2.059332198,1.042176575,{"v":2.783e-223,"d":"2.78E-223"},{"v":3.8208E-222,"d":"3.82E-222"},"up","yes","Spsb1","protein_coding","chr5:160358308-160418468:-","gi|982947880|ref|XP_015330574.1|",1475,0,"PREDICTED: SPRY domain-containing SOCS box protein 1 isoform X4 [Bos taurus]","gi|672054516|ref|XM_006239462.2|",2031,0,"PREDICTED: Rattus norvegicus splA/ryanodine receptor domain and SOCS box containing 1 (Spsb1), transcript variant X2, mRNA","Q9D5L7",563,0,"SPRY domain-containing SOCS box protein 1",".",".",".",".","pfam00622","SPRY","SPRY domain. SPRY Domain is named from SPla and the RYanodine Receptor. Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.","GO:0006511|ubiquitin-dependent protein catabolic process;GO:0016567|protein ubiquitination;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;","GO:0005829|cytosol;GO:0019005|SCF ubiquitin ligase complex;","GO:1990756|protein binding, bridging involved in substrate recognition for ubiquitination;","K10343","SPSB1_4, SSB1, SSB4; SPRY domain-containing SOCS box protein 1/4"]
["ENSRNOG00000033402",1820,117.0813975,387,24.98543969,4.685985076,2.22835236,{"v":1.0043E-219,"d":"1.00E-219"},{"v":1.3528e-218,"d":"1.35E-218"},"up","yes","Gsta6","protein_coding","chr9:23744288-23801131:-","gi|66730521|ref|NP_001019532.1|",1180,{"v":3E-160,"d":"3.00E-160"},"glutathione S-transferase A6 [Rattus norvegicus]","gi|672064615|ref|XM_006244656.2|",1062,0,"PREDICTED: Rattus norvegicus similar to Glutathione S-transferase A1 (GTH1) (HA subunit 1) (GST-epsilon) (GSTA1-1) (GST class-alpha) (LOC501110), transcript variant X1, mRNA","Q6AXY0",459,{"v":9e-162,"d":"9.00E-162"},"Glutathione S-transferase A6",".",".",".",".","pfam00043","GST_C","Glutathione S-transferase, C-terminal domain. GST conjugates reduced glutathione to a variety of targets including S-crystallin from squid, the eukaryotic elongation factor 1-gamma, the HSP26 family of stress-related proteins and auxin-regulated proteins in plants. Stringent starvation proteins in Escherichia coli are also included in the alignment but are not known to have GST activity.     The glutathione molecule binds in a cleft between N and C-terminal domains. The catalytically important residues are proposed to reside in the N-terminal domain. In plants, GSTs are encoded by a large gene family (48 GST genes in Arabidopsis) and can be divided into the phi, tau, theta, zeta, and lambda classes.","GO:0006749|glutathione metabolic process;GO:0006805|xenobiotic metabolic process;GO:0009617|response to bacterium;GO:0035634|response to stilbenoid;","GO:0005829|cytosol;","GO:0004364|glutathione transferase activity;","K00799","GST, gst; glutathione S-transferase [EC:2.5.1.18]"]
["ENSRNOG00000048682",4927,316.9560689,2267,146.3617358,2.165566479,1.114744461,{"v":5.1619e-219,"d":"5.16E-219"},{"v":6.9367e-218,"d":"6.94E-218"},"up","yes","Zwint","protein_coding","chr20:15938157-15953957:-","gi|22129759|ref|NP_671479.1|",1208,{"v":1e-160,"d":"1.00E-160"},"ZW10 interactor [Rattus norvegicus]","gi|38969841|gb|BC063144.1|",1082,0,"Rattus norvegicus ZW10 interactor, mRNA (cDNA clone MGC:72643 IMAGE:6921645), complete cds","Q8VIL3",469,{"v":5e-162,"d":"5.00E-162"},"ZW10 interactor",".",".",".",".","pfam15556","Zwint","ZW10 interactor. This family of proteins is found in eukaryotes. Proteins in this family are typically between 127 and 281 amino acids in length.","GO:0000070|mitotic sister chromatid segregation;GO:0007093|mitotic cell cycle checkpoint;GO:0007094|mitotic spindle assembly checkpoint;GO:0051301|cell division;GO:0051649|establishment of localization in cell;","GO:0000776|kinetochore;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016604|nuclear body;GO:0030425|dendrite;GO:0043005|neuron projection;GO:0043231|intracellular membrane-bounded organelle;","GO:0005515|protein binding;GO:0047485|protein N-terminus binding;","K19943","ZWINT; ZW10 interactor"]
["ENSRNOG00000030391",3725,239.6308822,1476,95.29330485,2.514666509,1.330367085,{"v":7.686e-219,"d":"7.69E-219"},{"v":1.028E-217,"d":"1.03E-217"},"up","yes","Ei24","protein_coding","chr8:36494289-36510571:-","gi|74186207|dbj|BAE42899.1|",1526,0,"unnamed protein product [Mus musculus]","gi|71043693|ref|NM_001025660.1|",2043,0,"Rattus norvegicus EI24, autophagy associated transmembrane protein (Ei24), mRNA","Q4KM77",564,0,"Etoposide-induced protein 2.4 homolog",".",".",".",".","pfam07264","EI24","Etoposide-induced protein 2.4 (EI24). This family contains a number of eukaryotic etoposide-induced 2.4 (EI24) proteins approximately 350 residues long as well as bacterial CysZ proteins (formerly known as DUF540). In cells treated with the cytotoxic drug etoposide, EI24 is induced by p53. It has been suggested to play an important role in negative cell growth control.","GO:0006914|autophagy;GO:0008630|intrinsic apoptotic signaling pathway in response to DNA damage;GO:0009410|response to xenobiotic stimulus;GO:0016236|macroautophagy;GO:0030308|negative regulation of cell growth;GO:0042308|negative regulation of protein import into nucleus;GO:0050885|neuromuscular process controlling balance;GO:0071494|cellular response to UV-C;GO:2001244|positive regulation of intrinsic apoptotic signaling pathway;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0016021|integral component of membrane;GO:0031965|nuclear membrane;","GO:0061676|importin-alpha family protein binding;","K10134","EI24; etoposide-induced 2.4 mRNA"]
["ENSRNOG00000050794",3265,210.0388807,1197,77.28054601,2.717875216,1.44247922,{"v":6.3014e-217,"d":"6.30E-217"},{"v":8.3696e-216,"d":"8.37E-216"},"up","yes","Pdlim4","protein_coding","chr10:38198689-38212938:-","gi|149052601|gb|EDM04418.1|",1667,0,"reversion induced LIM gene, isoform CRA_a [Rattus norvegicus]","gi|402691676|ref|NM_017062.2|",1161,0,"Rattus norvegicus PDZ and LIM domain 4 (Pdlim4), mRNA","P70271",629,0,"PDZ and LIM domain protein 4",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.","GO:0007507|heart development;GO:0030036|actin cytoskeleton organization;GO:0031532|actin cytoskeleton reorganization;GO:0051496|positive regulation of stress fiber assembly;GO:0061061|muscle structure development;GO:0098976|excitatory chemical synaptic transmission;","GO:0001725|stress fiber;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005912|adherens junction;GO:0015629|actin cytoskeleton;GO:0030018|Z disc;GO:0030027|lamellipodium;GO:0031901|early endosome membrane;GO:0031905|early endosome lumen;GO:0031941|filamentous actin;GO:0034777|recycling endosome lumen;GO:0043197|dendritic spine;GO:0045211|postsynaptic membrane;GO:0048471|perinuclear region of cytoplasm;GO:0055038|recycling endosome membrane;","GO:0003779|actin binding;GO:0005515|protein binding;GO:0019903|protein phosphatase binding;GO:0042803|protein homodimerization activity;GO:0042805|actinin binding;GO:0046872|metal ion binding;GO:0051371|muscle alpha-actinin binding;GO:0051393|alpha-actinin binding;","K23353","PDLIM1_2_3_4; PDZ and LIM domain protein 1/2/3/4"]
["ENSRNOG00000017163",4516,290.5162588,2012,129.8984616,2.236487293,1.161234562,{"v":2.1419e-214,"d":"2.14E-214"},{"v":2.8122e-213,"d":"2.81E-213"},"up","yes","Pfkp","protein_coding","chr17:63729780-63794018:+","gi|57977273|ref|NP_996729.1|",3799,0,"ATP-dependent 6-phosphofructokinase, platelet type [Rattus norvegicus]","gi|672082475|ref|XM_008771885.1|",2510,0,"PREDICTED: Rattus norvegicus phosphofructokinase, platelet (Pfkp), transcript variant X1, mRNA","P47860",1467,0,"ATP-dependent 6-phosphofructokinase, platelet type","SPBC16H5.02",595,0,"COG0205","pfam00365","PFK","Phosphofructokinase.","GO:0006002|fructose 6-phosphate metabolic process;GO:0006096|glycolytic process;GO:0030388|fructose 1,6-bisphosphate metabolic process;GO:0061615|glycolytic process through fructose-6-phosphate;GO:0061621|canonical glycolysis;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005945|6-phosphofructokinase complex;GO:0016020|membrane;","GO:0003872|6-phosphofructokinase activity;GO:0005524|ATP binding;GO:0016208|AMP binding;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;GO:0046872|metal ion binding;GO:0048029|monosaccharide binding;GO:0070095|fructose-6-phosphate binding;","K00850","pfkA, PFK; 6-phosphofructokinase 1 [EC:2.7.1.11]"]
["ENSRNOG00000021812",1204,77.45384757,131,8.457603615,9.157895203,3.195016056,{"v":8.3374e-214,"d":"8.34E-214"},{"v":1.0872e-212,"d":"1.09E-212"},"up","yes","Scx","protein_coding","chr7:108176608-108178626:+","gi|194473618|ref|NP_001123980.1|",709,{"v":7e-89,"d":"7.00E-89"},"basic helix-loop-helix transcription factor scleraxis [Rattus norvegicus]","gi|194473617|ref|NM_001130508.1|",1134,0,"Rattus norvegicus scleraxis bHLH transcription factor (Scx), mRNA","Q64124",273,{"v":1e-88,"d":"1.00E-88"},"Basic helix-loop-helix transcription factor scleraxis",".",".",".",".","pfam00010","HLH","Helix-loop-helix DNA-binding domain.","GO:0001707|mesoderm formation;GO:0001894|tissue homeostasis;GO:0001958|endochondral ossification;GO:0002062|chondrocyte differentiation;GO:0003179|heart valve morphogenesis;GO:0003188|heart valve formation;GO:0006351|transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008284|positive regulation of cell proliferation;GO:0010628|positive regulation of gene expression;GO:0030154|cell differentiation;GO:0030199|collagen fibril organization;GO:0030509|BMP signaling pathway;GO:0032502|developmental process;GO:0032967|positive regulation of collagen biosynthetic process;GO:0035914|skeletal muscle cell differentiation;GO:0035989|tendon development;GO:0035990|tendon cell differentiation;GO:0035992|tendon formation;GO:0035993|deltoid tuberosity development;GO:0043066|negative regulation of apoptotic process;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048706|embryonic skeletal system development;GO:0060325|face morphogenesis;GO:0061035|regulation of cartilage development;GO:0061036|positive regulation of cartilage development;GO:0061056|sclerotome development;GO:0071260|cellular response to mechanical stimulus;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0071773|cellular response to BMP stimulus;GO:2000543|positive regulation of gastrulation;","GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987|proximal promoter sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0043425|bHLH transcription factor binding;GO:0043565|sequence-specific DNA binding;GO:0046983|protein dimerization activity;GO:0070888|E-box binding;",".","."]
["ENSRNOG00000009298",1850,119.0113106,417,26.92229548,4.420548417,2.144225363,{"v":5.5166e-213,"d":"5.52E-213"},{"v":7.1607e-212,"d":"7.16E-212"},"up","yes","Fbxo44","protein_coding","chr5:158583366-158592363:-","gi|672054612|ref|XP_006239460.2|",1151,{"v":3E-152,"d":"3.00E-152"},"PREDICTED: F-box only protein 44 isoform X5 [Rattus norvegicus]","gi|564354082|ref|XM_006239393.1|",1415,0,"PREDICTED: Rattus norvegicus F-box protein 44 (Fbxo44), transcript variant X2, mRNA","Q8BK26",226,{"v":7e-68,"d":"7.00E-68"},"F-box only protein 44",".",".",".",".","pfam04300","FBA","F-box associated region. Members of this family are associated with F-box domains, hence the name FBA. This domain is probably involved in binding other proteins that will be targeted for ubiquitination. Human FBXO2 is involved in binding to N-glycosylated proteins.","GO:0006516|glycoprotein catabolic process;GO:0010498|proteasomal protein catabolic process;GO:0016567|protein ubiquitination;GO:0030433|ubiquitin-dependent ERAD pathway;GO:0031146|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;","GO:0005737|cytoplasm;GO:0019005|SCF ubiquitin ligase complex;","GO:0061630|ubiquitin protein ligase activity;","K10103","FBXO44; F-box protein 44"]
["ENSRNOG00000033206",1690,108.7184405,343,22.14471786,4.909452503,2.295562146,{"v":1.2917E-211,"d":"1.29E-211"},{"v":1.6576e-210,"d":"1.66E-210"},"up","yes","Entpd5","protein_coding","chr6:104019185-104055530:-","gi|149025140|gb|EDL81507.1|",2413,0,"ectonucleoside triphosphate diphosphohydrolase 5, isoform CRA_c [Rattus norvegicus]","gi|672056584|ref|XM_006240346.2|",4542,0,"PREDICTED: Rattus norvegicus ectonucleoside triphosphate diphosphohydrolase 5 (Entpd5), transcript variant X4, mRNA","Q6P6S9",875,0,"Ectonucleoside triphosphate diphosphohydrolase 5","SPAC824.08",200,{"v":8e-53,"d":"8.00E-53"},"COG5371","pfam01150","GDA1_CD39","GDA1/CD39 (nucleoside phosphatase) family.","GO:0006487|protein N-linked glycosylation;GO:0009134|nucleoside diphosphate catabolic process;GO:0014066|regulation of phosphatidylinositol 3-kinase signaling;GO:0045821|positive regulation of glycolytic process;GO:0046034|ATP metabolic process;GO:0051084|'de novo' posttranslational protein folding;","GO:0005576|extracellular region;GO:0005783|endoplasmic reticulum;GO:0005788|endoplasmic reticulum lumen;GO:0016020|membrane;","GO:0004382|guanosine-diphosphatase activity;GO:0005524|ATP binding;GO:0017110|nucleoside-diphosphatase activity;GO:0045134|uridine-diphosphatase activity;","K01511","ENTPD5_6; ectonucleoside triphosphate diphosphohydrolase 5/6 [EC:3.6.1.6]"]
["ENSRNOG00000009358",1878,120.8125629,435,28.08440895,4.301766262,2.104929138,{"v":3.1287e-211,"d":"3.13E-211"},{"v":3.9886e-210,"d":"3.99E-210"},"up","yes","Osgin2","protein_coding","chr5:29500408-29520831:-","gi|293347270|ref|XP_001056612.2|",2872,0,"PREDICTED: oxidative stress-induced growth inhibitor 2 isoform X1 [Rattus norvegicus]","gi|672019168|ref|XM_001056612.5|",2363,0,"PREDICTED: Rattus norvegicus oxidative stress induced growth inhibitor family member 2 (Osgin2), transcript variant X1, mRNA","Q9Y236",949,0,"Oxidative stress-induced growth inhibitor 2",".",".",".",".","pfam13738","Pyr_redox_3","Pyridine nucleotide-disulphide oxidoreductase.","GO:0007165|signal transduction;GO:0030308|negative regulation of cell growth;",".","GO:0008083|growth factor activity;",".","."]
["ENSRNOG00000038746",2209,142.105938,607,39.18904881,3.626164509,1.858444378,{"v":5.8769E-211,"d":"5.88E-211"},{"v":7.4589e-210,"d":"7.46E-210"},"up","yes","Bco2","protein_coding","chr8:50882181-50915467:-","gi|189181706|ref|NP_001121184.1|",2800,0,"beta,beta-carotene 9',10'-oxygenase [Rattus norvegicus]","gi|189181705|ref|NM_001127712.1|",2509,0,"Rattus norvegicus beta-carotene oxygenase 2 (Bco2), mRNA","Q99NF1",1017,0,"Beta,beta-carotene 9',10'-oxygenase","all1106",94,{"v":3e-19,"d":"3.00E-19"},"COG3670","pfam03055","RPE65","Retinal pigment epithelial membrane protein. This family represents a retinal pigment epithelial membrane receptor which is abundantly expressed in retinal pigment epithelium, and binds plasma retinal binding protein. The family also includes the sequence related neoxanthin cleavage enzyme in plants and lignostilbene-alpha,beta-dioxygenase in bacteria.","GO:0006412|translation;GO:0016116|carotenoid metabolic process;GO:0016119|carotene metabolic process;GO:0016121|carotene catabolic process;GO:0016122|xanthophyll metabolic process;GO:0042574|retinal metabolic process;GO:0051881|regulation of mitochondrial membrane potential;GO:2000377|regulation of reactive oxygen species metabolic process;","GO:0005739|mitochondrion;GO:0005840|ribosome;","GO:0003735|structural constituent of ribosome;GO:0003834|beta-carotene 15,15'-monooxygenase activity;GO:0010436|carotenoid dioxygenase activity;GO:0016702|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;GO:0046872|metal ion binding;","K10252","BCDO2; beta,beta-carotene 9',10'-dioxygenase [EC:1.13.11.71]"]
["ENSRNOG00000070930",2261,145.4511207,637,41.1259046,3.536727572,1.822415095,{"v":3.003E-210,"d":"3.00E-210"},{"v":3.8029e-209,"d":"3.80E-209"},"up","yes","Hilpda","lncRNA","chr4:57871110-57874557:+","gi|149065133|gb|EDM15209.1|",406,{"v":2e-44,"d":"2.00E-44"},"rCG28212 [Rattus norvegicus]","gi|34368613|gb|AC096035.6|",1343,0,"Rattus norvegicus 4 BAC CH230-16M16 (Children's Hospital Oakland Research Institute) complete sequence","Q9JLS0",121,{"v":6e-32,"d":"6.00E-32"},"Hypoxia-inducible lipid droplet-associated protein",".",".",".",".","pfam15220","HILPDA","Hypoxia-inducible lipid droplet-associated. This family of proteins stimulate intracellular lipid accumulation, function as autocrine growth factors and enhance cell growth.",".",".",".",".","."]
["ENSRNOG00000032401",1730,111.2916581,370,23.88788807,4.658915754,2.219994243,{"v":5.2144e-208,"d":"5.21E-208"},{"v":6.5309e-207,"d":"6.53E-207"},"up","yes","H3f3c","protein_coding","chr7:86501071-86502140:+","gi|755472894|ref|XP_006543746.2|",760,{"v":1e-96,"d":"1.00E-96"},"PREDICTED: LOW QUALITY PROTEIN: histone H3.3C isoform X1 [Mus musculus]","gi|672021859|ref|XM_003754308.3|",1050,0,"PREDICTED: Rattus norvegicus H3 histone, family 3C (H3f3c), mRNA","Q6P823",271,{"v":2e-89,"d":"2.00E-89"},"Histone H3.3",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.","GO:0001649|osteoblast differentiation;GO:0006334|nucleosome assembly;GO:0006336|DNA replication-independent nucleosome assembly;GO:0007283|spermatogenesis;GO:0007338|single fertilization;GO:0008150|biological_process;GO:0008283|cell proliferation;GO:0030307|positive regulation of cell growth;GO:0031508|pericentric heterochromatin assembly;GO:0031509|telomeric heterochromatin assembly;GO:0035264|multicellular organism growth;GO:0042692|muscle cell differentiation;GO:0048477|oogenesis;GO:1902340|negative regulation of chromosome condensation;","GO:0000228|nuclear chromosome;GO:0000781|chromosome, telomeric region;GO:0000786|nucleosome;GO:0001740|Barr body;GO:0005575|cellular_component;GO:0005634|nucleus;GO:0032991|protein-containing complex;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000979|RNA polymerase II core promoter sequence-specific DNA binding;GO:0003674|molecular_function;GO:0031492|nucleosomal DNA binding;GO:0046982|protein heterodimerization activity;","K11253","H3; histone H3"]
["ENSRNOG00000031934",2416,155.4223387,740,47.77577614,3.253161983,1.701842659,{"v":2.4369e-204,"d":"2.44E-204"},{"v":2.9932e-203,"d":"2.99E-203"},"up","yes","Enah","protein_coding","chr13:93626944-93740955:-","gi|564382092|ref|XP_006250462.1|",1014,{"v":4e-117,"d":"4.00E-117"},"PREDICTED: protein enabled homolog isoform X5 [Rattus norvegicus]","gi|755495436|ref|XM_006496647.2|",2456,0,"PREDICTED: Mus musculus enabled homolog (Drosophila) (Enah), transcript variant X10, mRNA","Q8N8S7",370,{"v":4e-110,"d":"4.00E-110"},"Protein enabled homolog",".",".",".",".","pfam00568","WH1","WH1 domain. WASp Homology domain 1 (WH1) domain. WASP is the protein that is defective in Wiskott-Aldrich syndrome (WAS). The majority of point mutations occur within the amino- terminal WH1 domain. The metabotropic glutamate receptors mGluR1alpha and mGluR5 bind a protein called homer, which is a WH1 domain homologue. A subset of WH1 domains has been termed a \"EVH1\" domain and appear to bind a polyproline motif.","GO:0001843|neural tube closure;GO:0007015|actin filament organization;GO:0007411|axon guidance;GO:0008154|actin polymerization or depolymerization;GO:0030036|actin cytoskeleton organization;GO:0070358|actin polymerization-dependent cell motility;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0001725|stress fiber;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005925|focal adhesion;GO:0030027|lamellipodium;GO:0030054|cell junction;GO:0030175|filopodium;","GO:0003779|actin binding;GO:0005515|protein binding;GO:0005522|profilin binding;GO:0017124|SH3 domain binding;GO:0050699|WW domain binding;","K05746","ENAH, MENA; enabled"]
["ENSRNOG00000070875",1854,119.2686324,442,28.53634197,4.179534733,2.06334235,{"v":2.3202e-203,"d":"2.32E-203"},{"v":2.8375e-202,"d":"2.84E-202"},"up","yes","Nat8f4","protein_coding","chr4:118325874-118332658:-","gi|564303978|ref|XP_006225040.1|",1128,{"v":3e-138,"d":"3.00E-138"},"PREDICTED: probable N-acetyltransferase CML2 [Rattus norvegicus]","gi|672050329|ref|XM_008763098.1|",5328,0,"PREDICTED: Rattus norvegicus probable N-acetyltransferase CML2-like (LOC102556148), transcript variant X1, mRNA","P85118",399,{"v":2E-125,"d":"2.00E-125"},"N-acetyltransferase family 8 member 2",".",".",".",".","pfam00583","Acetyltransf_1","Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.",".",".",".",".","."]
["ENSRNOG00000018782",1121,72.11442121,120,7.747423159,9.308181537,3.218499348,{"v":1.6949E-200,"d":"1.69E-200"},{"v":2.0336e-199,"d":"2.03E-199"},"up","yes","Gmnn","protein_coding","chr17:40301808-40310054:+","gi|157820093|ref|NP_001099582.1|",1083,{"v":3e-145,"d":"3.00E-145"},"geminin [Rattus norvegicus]","gi|157820092|ref|NM_001106112.1|",1178,0,"Rattus norvegicus geminin, DNA replication inhibitor (Gmnn), mRNA","O88513",375,{"v":1e-128,"d":"1.00E-128"},"Geminin",".",".",".",".","pfam07412","Geminin","Geminin. This family contains the eukaryotic protein geminin (approximately 200 residues long). Geminin inhibits DNA replication by preventing the incorporation of MCM complex into prereplication complex, and is degraded during the mitotic phase of the cell cycle. It has been proposed that geminin inhibits DNA replication during S, G2, and M phases and that geminin destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.","GO:0006275|regulation of DNA replication;GO:0008156|negative regulation of DNA replication;GO:0009887|animal organ morphogenesis;GO:0035563|positive regulation of chromatin binding;GO:0045786|negative regulation of cell cycle;GO:0045892|negative regulation of transcription, DNA-templated;GO:0065003|protein-containing complex assembly;GO:0071163|DNA replication preinitiation complex assembly;GO:2000104|negative regulation of DNA-dependent DNA replication;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0003682|chromatin binding;GO:0003714|transcription corepressor activity;GO:0042826|histone deacetylase binding;","K10749","GMNN; geminin"]
["ENSRNOG00000016690",3003,193.1843059,1098,70.8889219,2.72516919,1.446345801,{"v":1.7614e-200,"d":"1.76E-200"},{"v":2.109e-199,"d":"2.11E-199"},"up","yes","Idi1","protein_coding","chr17:61629594-61637357:-","gi|399567836|ref|NP_445991.2|",1452,0,"isopentenyl-diphosphate Delta-isomerase 1 [Rattus norvegicus]","gi|399567835|ref|NM_053539.2|",2811,0,"Rattus norvegicus isopentenyl-diphosphate delta isomerase 1 (Idi1), mRNA","O35760",449,{"v":7e-150,"d":"7.00E-150"},"Isopentenyl-diphosphate Delta-isomerase 1","SPBC106.15",223,{"v":1e-65,"d":"1.00E-65"},"COG1443","pfam00293","NUDIX","NUDIX domain.","GO:0006695|cholesterol biosynthetic process;GO:0008299|isoprenoid biosynthetic process;GO:0009240|isopentenyl diphosphate biosynthetic process;GO:0035634|response to stilbenoid;GO:0050992|dimethylallyl diphosphate biosynthetic process;","GO:0005737|cytoplasm;GO:0005777|peroxisome;","GO:0000287|magnesium ion binding;GO:0004452|isopentenyl-diphosphate delta-isomerase activity;GO:0030145|manganese ion binding;GO:0046872|metal ion binding;","K01823","idi, IDI; isopentenyl-diphosphate Delta-isomerase [EC:5.3.3.2]"]
["ENSRNOG00000023861",840,54.03756808,13,0.839304176,64.38377129,6.00862518,{"v":4.1293E-199,"d":"4.13E-199"},{"v":4.9031e-198,"d":"4.90E-198"},"up","yes","Snap91","protein_coding","chr8:87738824-87852367:-","gi|564364792|ref|XP_006243556.1|",2792,0,"PREDICTED: clathrin coat assembly protein AP180 isoform X3 [Rattus norvegicus]","gi|13994176|ref|NM_031728.1|",2737,0,"Rattus norvegicus synaptosomal-associated protein 91 (Snap91), mRNA","Q61548",725,0,"Clathrin coat assembly protein AP180",".",".",".",".","pfam07651","ANTH","ANTH domain. AP180 is an endocytotic accessory proteins that has been implicated in the formation of clathrin-coated pits.  The domain is involved in phosphatidylinositol 4,5-bisphosphate binding and is a universal adaptor for nucleation of clathrin coats.","GO:0006900|vesicle budding from membrane;GO:0007163|establishment or maintenance of cell polarity;GO:0007268|chemical synaptic transmission;GO:0007269|neurotransmitter secretion;GO:0007409|axonogenesis;GO:0015031|protein transport;GO:0016185|synaptic vesicle budding from presynaptic endocytic zone membrane;GO:0030100|regulation of endocytosis;GO:0048268|clathrin coat assembly;GO:0048488|synaptic vesicle endocytosis;GO:0048666|neuron development;GO:0050772|positive regulation of axonogenesis;GO:0051223|regulation of protein transport;GO:0051899|membrane depolarization;GO:0072583|clathrin-dependent endocytosis;GO:1900242|regulation of synaptic vesicle endocytosis;GO:1900244|positive regulation of synaptic vesicle endocytosis;GO:1900275|negative regulation of phospholipase C activity;GO:1904006|negative regulation of phospholipase D activity;GO:1905445|positive regulation of clathrin coat assembly;GO:2000331|regulation of terminal button organization;GO:2000369|regulation of clathrin-dependent endocytosis;GO:2000809|positive regulation of synaptic vesicle clustering;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005905|clathrin-coated pit;GO:0008021|synaptic vesicle;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0030136|clathrin-coated vesicle;GO:0031313|extrinsic component of endosome membrane;GO:0042734|presynaptic membrane;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0043679|axon terminus;GO:0045211|postsynaptic membrane;GO:0048787|presynaptic active zone membrane;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098688|parallel fiber to Purkinje cell synapse;GO:0098830|presynaptic endosome;GO:0098833|presynaptic endocytic zone;GO:0098894|extrinsic component of presynaptic endocytic zone membrane;","GO:0000149|SNARE binding;GO:0000822|inositol hexakisphosphate binding;GO:0005515|protein binding;GO:0005545|1-phosphatidylinositol binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0019901|protein kinase binding;GO:0030276|clathrin binding;GO:0032050|clathrin heavy chain binding;GO:0035615|clathrin adaptor activity;GO:0042169|SH2 domain binding;GO:0043274|phospholipase binding;","K20043","SNAP91, AP180, CALM; clathrin coat assembly protein AP180"]
["ENSRNOG00000003869",3855,247.9938392,1645,106.2042591,2.335064914,1.223462657,{"v":5.752e-199,"d":"5.75E-199"},{"v":6.8157e-198,"d":"6.82E-198"},"up","yes","Sod3","protein_coding","chr14:58609958-58615990:-","gi|564383837|ref|XP_006251092.1|",1235,{"v":4e-163,"d":"4.00E-163"},"PREDICTED: extracellular superoxide dismutase [Cu-Zn] isoform X1 [Rattus norvegicus]","gi|6981567|ref|NM_012880.1|",1694,0,"Rattus norvegicus superoxide dismutase 3, extracellular (Sod3), mRNA","Q08420",469,{"v":1e-160,"d":"1.00E-160"},"Extracellular superoxide dismutase [Cu-Zn]","SPAC821.10c",107,{"v":1E-25,"d":"1.00E-25"},"COG2032","pfam00080","Sod_Cu","Copper/zinc superoxide dismutase (SODC). superoxide dismutases (SODs) catalyse the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the human SOD1 gene cause familial amyotrophic lateral sclerosis (Lou Gehrig's disease). Structure is an eight-stranded beta sandwich, similar to the immunoglobulin fold.","GO:0001666|response to hypoxia;GO:0006979|response to oxidative stress;GO:0019430|removal of superoxide radicals;GO:0046688|response to copper ion;GO:0097746|regulation of blood vessel diameter;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0062023|collagen-containing extracellular matrix;","GO:0004784|superoxide dismutase activity;GO:0005507|copper ion binding;","K16627","SOD3; superoxide dismutase, Cu-Zn family [EC:1.15.1.1]"]
["ENSRNOG00000001700",2085,134.1289636,578,37.31675488,3.594336218,1.845725366,{"v":2.1109e-197,"d":"2.11E-197"},{"v":2.4705e-196,"d":"2.47E-196"},"up","yes","Whrn","protein_coding","chr5:76828301-76912223:-","gi|149059586|gb|EDM10524.1|",4104,0,"CASK-interacting protein CIP98, isoform CRA_b [Rattus norvegicus]","gi|755506881|ref|XM_006538309.2|",3456,0,"PREDICTED: Mus musculus whirlin (Whrn), transcript variant X1, mRNA","Q810W9",1582,0,"Whirlin",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.","GO:0001895|retina homeostasis;GO:0007605|sensory perception of sound;GO:0010628|positive regulation of gene expression;GO:0021694|cerebellar Purkinje cell layer formation;GO:0045184|establishment of protein localization;GO:0050910|detection of mechanical stimulus involved in sensory perception of sound;GO:0050953|sensory perception of light stimulus;GO:0060088|auditory receptor cell stereocilium organization;GO:0060122|inner ear receptor cell stereocilium organization;GO:1990227|paranodal junction maintenance;","GO:0001917|photoreceptor inner segment;GO:0002141|stereocilia ankle link;GO:0002142|stereocilia ankle link complex;GO:0005737|cytoplasm;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0005929|cilium;GO:0016020|membrane;GO:0030426|growth cone;GO:0032391|photoreceptor connecting cilium;GO:0032420|stereocilium;GO:0032421|stereocilium bundle;GO:0032426|stereocilium tip;GO:0036064|ciliary basal body;GO:0043025|neuronal cell body;GO:0043198|dendritic shaft;GO:0044303|axon collateral;GO:0048471|perinuclear region of cytoplasm;GO:0097440|apical dendrite;GO:0098793|presynapse;GO:0098794|postsynapse;GO:1990075|periciliary membrane compartment;GO:1990696|USH2 complex;","GO:0019904|protein domain specific binding;GO:0042802|identical protein binding;","K21879","WHRN, USH2D; whirlin"]
["ENSRNOG00000066314",1613,103.7649968,342,22.080156,4.699468463,2.232497589,{"v":2.0657e-195,"d":"2.07E-195"},{"v":2.4028E-194,"d":"2.40E-194"},"up","yes","Bean1","protein_coding","chr19:739551-787537:-","gi|564321041|ref|XP_006222720.1|",844,{"v":4e-99,"d":"4.00E-99"},"PREDICTED: protein BEAN1 [Rattus norvegicus]","gi|672031012|ref|XM_008774191.1|",2480,0,"PREDICTED: Rattus norvegicus brain expressed, associated with NEDD4, 1 (Bean1), transcript variant X2, mRNA","Q9EQG5",286,{"v":1e-85,"d":"1.00E-85"},"Protein BEAN1",".",".",".",".","pfam12723","DUF3809","Protein of unknown function (DUF3809). This family of proteins is functionally uncharacterized. This family of proteins is found in Deinococci bacteria. Proteins in this family are typically between 117 and 157 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000014254",2699,173.6278527,935,60.36533878,2.87628391,1.524206087,{"v":7.7661e-195,"d":"7.77E-195"},{"v":8.9424e-194,"d":"8.94E-194"},"up","yes","Cpt1a","protein_coding","chr1:200565613-200627055:+","gi|162287173|ref|NP_113747.2|",4068,0,"carnitine O-palmitoyltransferase 1, liver isoform [Rattus norvegicus]","gi|564332055|ref|XM_006230695.1|",3878,0,"PREDICTED: Rattus norvegicus carnitine palmitoyltransferase 1a, liver (Cpt1a), transcript variant X1, mRNA","P32198",1566,0,"Carnitine O-palmitoyltransferase 1, liver isoform",".",".",".",".","pfam00755","Carn_acyltransf","Choline/Carnitine o-acyltransferase.","GO:0001676|long-chain fatty acid metabolic process;GO:0006006|glucose metabolic process;GO:0006631|fatty acid metabolic process;GO:0006635|fatty acid beta-oxidation;GO:0006641|triglyceride metabolic process;GO:0009410|response to xenobiotic stimulus;GO:0009437|carnitine metabolic process;GO:0010876|lipid localization;GO:0010883|regulation of lipid storage;GO:0014070|response to organic cyclic compound;GO:0030855|epithelial cell differentiation;GO:0031667|response to nutrient levels;GO:0031998|regulation of fatty acid beta-oxidation;GO:0032000|positive regulation of fatty acid beta-oxidation;GO:0042755|eating behavior;GO:0043279|response to alkaloid;GO:0045471|response to ethanol;GO:0046320|regulation of fatty acid oxidation;GO:0046677|response to antibiotic;GO:0050796|regulation of insulin secretion;GO:0071398|cellular response to fatty acid;GO:0097421|liver regeneration;GO:1904772|response to tetrachloromethane;","GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0016021|integral component of membrane;GO:0031307|integral component of mitochondrial outer membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0004095|carnitine O-palmitoyltransferase activity;GO:0005515|protein binding;GO:0042802|identical protein binding;GO:1990698|palmitoleoyltransferase activity;","K08765","CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [EC:2.3.1.21]"]
["ENSRNOG00000030091",1362,87.61805681,228,14.720104,5.952271587,2.573440354,{"v":8.0844e-195,"d":"8.08E-195"},{"v":9.2902e-194,"d":"9.29E-194"},"up","yes","Dusp14","protein_coding","chr10:68935330-68965329:-","gi|120586975|ref|NP_001073362.1|",1069,{"v":2e-135,"d":"2.00E-135"},"dual specificity protein phosphatase 14 [Rattus norvegicus]","gi|354791184|gb|JN955685.1|",1421,0,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Dusp14:tm1e(EUCOMM)Wtsi; transgenic","Q9JLY7",412,{"v":4e-135,"d":"4.00E-135"},"Dual specificity protein phosphatase 14","YIL113w",75.5,{"v":5e-14,"d":"5.00E-14"},"COG2453","pfam00782","DSPc","Dual specificity phosphatase, catalytic domain. Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a \"recognition\" region.","GO:0035335|peptidyl-tyrosine dephosphorylation;",".","GO:0004725|protein tyrosine phosphatase activity;GO:0017017|MAP kinase tyrosine/serine/threonine phosphatase activity;","K14165","K14165; atypical dual specificity phosphatase [EC:3.1.3.16 3.1.3.48]"]
["ENSRNOG00000021808",4661,299.8441724,2218,143.1982047,2.093910136,1.066199528,{"v":5.2983e-193,"d":"5.30E-193"},{"v":6.0763e-192,"d":"6.08E-192"},"up","yes","Tecr","protein_coding","chr19:24541615-24568168:+","gi|564394832|ref|XP_006255278.1|",1704,0,"PREDICTED: very-long-chain enoyl-CoA reductase isoform X1 [Rattus norvegicus]","gi|672084315|ref|XM_006255216.2|",1227,0,"PREDICTED: Rattus norvegicus trans-2,3-enoyl-CoA reductase (Tecr), transcript variant X1, mRNA","Q64232",621,0,"Very-long-chain enoyl-CoA reductase",".",".",".",".","pfam02544","Steroid_dh","3-oxo-5-alpha-steroid 4-dehydrogenase. This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalysed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor <=> 3-oxo-delta(4)-steroid + reduced acceptor. The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally. A related enzyme is also found in plants is DET2, a steroid reductase from Arabidopsis. Mutations in this enzyme cause defects in light-regulated development.","GO:0006665|sphingolipid metabolic process;GO:0006694|steroid biosynthetic process;GO:0030497|fatty acid elongation;GO:0042761|very long-chain fatty acid biosynthetic process;","GO:0005783|endoplasmic reticulum;GO:0030176|integral component of endoplasmic reticulum membrane;","GO:0016491|oxidoreductase activity;GO:0102758|very-long-chain enoyl-CoA reductase activity;","K10258","TER, TSC13, CER10; very-long-chain enoyl-CoA reductase [EC:1.3.1.93]"]
["ENSRNOG00000002828",2277,146.4804077,698,45.06417804,3.250484401,1.700654731,{"v":1.6281e-192,"d":"1.63E-192"},{"v":1.8635e-191,"d":"1.86E-191"},"up","yes","Tob1","protein_coding","chr10:79160154-79165215:+","gi|82617614|ref|NP_579851.2|",1436,0,"protein Tob1 [Rattus norvegicus]","gi|82617613|ref|NM_133317.2|",2039,0,"Rattus norvegicus transducer of ErbB-2.1 (Tob1), mRNA","Q8R5K6",551,0,"Protein Tob1",".",".",".",".","pfam07742","BTG","BTG family.","GO:0008285|negative regulation of cell proliferation;GO:0010468|regulation of gene expression;GO:0017148|negative regulation of translation;GO:0030514|negative regulation of BMP signaling pathway;GO:0045668|negative regulation of osteoblast differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0060212|negative regulation of nuclear-transcribed mRNA poly(A) tail shortening;GO:0060213|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening;GO:0060390|regulation of SMAD protein signal transduction;GO:1900153|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0030014|CCR4-NOT complex;","GO:0003714|transcription corepressor activity;GO:0030971|receptor tyrosine kinase binding;GO:0046332|SMAD binding;","K14443","TOB; protein Tob/BTG"]
["ENSRNOG00000008236",2683,172.5985656,938,60.55902436,2.850088281,1.511006607,{"v":2.9774e-191,"d":"2.98E-191"},{"v":3.3807E-190,"d":"3.38E-190"},"up","yes","Decr1","protein_coding","chr5:29411172-29439018:-","gi|292781228|ref|NP_476545.2|",1681,0,"2,4-dienoyl-CoA reductase, mitochondrial precursor [Rattus norvegicus]","gi|292781227|ref|NM_057197.2|",995,0,"Rattus norvegicus 2,4-dienoyl CoA reductase 1, mitochondrial (Decr1), mRNA","Q64591",651,0,"2,4-dienoyl-CoA reductase, mitochondrial","Ta0205",227,{"v":6e-70,"d":"6.00E-70"},"COG1028","pfam13561","adh_short_C2","Enoyl-(Acyl carrier protein) reductase.","GO:0006635|fatty acid beta-oxidation;GO:0120162|positive regulation of cold-induced thermogenesis;","GO:0005654|nucleoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;GO:1902494|catalytic complex;","GO:0008670|2,4-dienoyl-CoA reductase (NADPH) activity;GO:0042802|identical protein binding;GO:0070402|NADPH binding;","K13236","DECR1; 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial [EC:1.3.1.124]"]
["ENSRNOG00000017448",2123,136.5735203,619,39.96379113,3.41743154,1.772912437,{"v":2.8612E-190,"d":"2.86E-190"},{"v":3.2294e-189,"d":"3.23E-189"},"up","yes","Exoc3l2","protein_coding","chr1:79112506-79145465:+","gi|564296972|ref|XP_006223178.1|",3115,0,"PREDICTED: exocyst complex component 3-like protein 2 isoform X1 [Rattus norvegicus]","gi|672013214|ref|XM_006223117.2|",3274,0,"PREDICTED: Rattus norvegicus exocyst complex component 3-like 2 (Exoc3l2), transcript variant X2, mRNA","Q2M3D2",657,0,"Exocyst complex component 3-like protein 2",".",".",".",".","pfam06046","Sec6","Exocyst complex component Sec6. Sec6 is a component of the multiprotein exocyst complex. Sec6 interacts with Sec8, Sec10 and Exo70.These exocyst proteins localize to regions of active exocytosis-at the growing ends of interphase cells and in the medial region of cells undergoing cytokinesis-in an F-actin-dependent and exocytosis- independent manner.","GO:0001701|in utero embryonic development;GO:0006887|exocytosis;GO:0051601|exocyst localization;","GO:0000145|exocyst;","GO:0000149|SNARE binding;","K19988","EXOC3L2; exocyst complex component 3-like protein 2"]
["ENSRNOG00000003902",1543,99.26186612,322,20.78891881,4.774748847,2.255424849,{"v":2.4067e-189,"d":"2.41E-189"},{"v":2.7005E-188,"d":"2.70E-188"},"up","yes","Fabp6","protein_coding","chr10:28063603-28068282:-","gi|149052320|gb|EDM04137.1|",672,{"v":8e-88,"d":"8.00E-88"},"fatty acid binding protein 6, ileal (gastrotropin) [Rattus norvegicus]","gi|8393345|ref|NM_017098.1|",484,0,"Rattus norvegicus fatty acid binding protein 6 (Fabp6), mRNA","P80020",259,{"v":2E-87,"d":"2.00E-87"},"Gastrotropin",".",".",".",".","pfam14651","Lipocalin_7","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2).","GO:0006869|lipid transport;GO:0008202|steroid metabolic process;","GO:0005829|cytosol;GO:0016020|membrane;","GO:0005504|fatty acid binding;GO:0008289|lipid binding;","K08755","FABP6; fatty acid-binding protein 6, ileal (gastrotropin)"]
["ENSRNOG00000067835",1374,88.39002207,244,15.75309376,5.610962738,2.488248332,{"v":2.6459e-189,"d":"2.65E-189"},{"v":2.963e-188,"d":"2.96E-188"},"up","yes","ENSRNOG00000067835","lncRNA","chr12:35662951-35668551:+","gi|149027698|gb|EDL83221.1|",199,{"v":3e-15,"d":"3.00E-15"},"rCG29124 [Rattus norvegicus]","gi|241982901|gb|AC136178.3|",611,0,"Rattus norvegicus CH230-435P16 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam00429","TLV_coat","ENV polyprotein (coat polyprotein).",".",".",".",".","."]
["ENSRNOG00000010517",2120,136.380529,621,40.09291485,3.401611718,1.766218472,{"v":5.0781E-189,"d":"5.08E-189"},{"v":5.6756E-188,"d":"5.68E-188"},"up","yes","Fam126a","protein_coding","chr4:11132385-11239113:+","gi|300794936|ref|NP_001178898.1|",2491,0,"hyccin [Rattus norvegicus]","gi|300794935|ref|NM_001191969.1|",1674,0,"Rattus norvegicus family with sequence similarity 126, member A (Fam126a), mRNA","Q6P9N1",924,0,"Hyccin",".",".",".",".","pfam09790","Hyccin","Hyccin. Members of this family of proteins may have a role in the beta-catenin-Tcf/Lef signaling pathway, as well as in the process of myelination of the central and peripheral nervous system. Defects in Hyccin are the cause of hypomyelination with congenital cataracts. This disorder is characterized by congenital cataracts, progressive neurologic impairment, and diffuse myelin deficiency. Affected individuals experience progressive pyramidal and cerebellar dysfunction, muscle weakness and wasting prevailing in the lower limbs.","GO:0042552|myelination;GO:0046854|phosphatidylinositol phosphorylation;GO:0072659|protein localization to plasma membrane;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0043005|neuron projection;",".","K21844","FAM126; protein FAM126"]
["ENSRNOG00000029651",854,54.93819421,45,2.905283684,18.90975208,4.241058544,{"v":3.1779e-186,"d":"3.18E-186"},{"v":3.5175e-185,"d":"3.52E-185"},"up","yes","Rdh16","protein_coding","chr7:63597536-63624124:+","gi|40363270|ref|NP_954678.1|",1686,0,"retinol dehydrogenase 2 precursor [Rattus norvegicus]","gi|40363269|ref|NM_199208.1|",1821,0,"Rattus norvegicus retinol dehydrogenase 16 (all-trans) (Rdh16), mRNA","P50170",654,0,"Retinol dehydrogenase 2",".",".",".",".","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.","GO:0001523|retinoid metabolic process;GO:0008202|steroid metabolic process;GO:0042572|retinol metabolic process;GO:0042573|retinoic acid metabolic process;GO:0042904|9-cis-retinoic acid biosynthetic process;GO:1900054|positive regulation of retinoic acid biosynthetic process;","GO:0005788|endoplasmic reticulum lumen;GO:0005789|endoplasmic reticulum membrane;GO:0031301|integral component of organelle membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0004745|retinol dehydrogenase activity;GO:0042802|identical protein binding;GO:0047023|androsterone dehydrogenase activity;GO:0047044|androstan-3-alpha,17-beta-diol dehydrogenase activity;","K11154","RDH16; retinol dehydrogenase 16 [EC:1.1.1.-]"]
["ENSRNOG00000007967",3976,255.7778222,1787,115.3720432,2.216982686,1.148597503,{"v":9.2298e-186,"d":"9.23E-186"},{"v":1.0196E-184,"d":"1.02E-184"},"up","yes","Sdhb","protein_coding","chr5:153264899-153314293:+","gi|209915614|ref|NP_001094009.1|",1379,0,"succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor [Rattus norvegicus]","gi|209915613|ref|NM_001100539.1|",971,0,"Rattus norvegicus succinate dehydrogenase complex iron sulfur subunit B (Sdhb), mRNA","P21913",535,0,"Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial","YLL041c",358,{"v":7e-118,"d":"7.00E-118"},"COG0479","pfam13085","Fer2_3","2Fe-2S iron-sulfur cluster binding domain. The 2Fe-2S ferredoxin family have a general core structure consisting of beta(2)-alpha-beta(2) which abeta-grasp type fold. The domain is around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated.","GO:0006099|tricarboxylic acid cycle;GO:0006105|succinate metabolic process;GO:0009060|aerobic respiration;GO:0022904|respiratory electron transport chain;","GO:0005654|nucleoplasm;GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0005749|mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone);GO:0005886|plasma membrane;GO:0031966|mitochondrial membrane;GO:0045273|respiratory chain complex II;","GO:0008177|succinate dehydrogenase (ubiquinone) activity;GO:0009055|electron transfer activity;GO:0046872|metal ion binding;GO:0048039|ubiquinone binding;GO:0051537|2 iron, 2 sulfur cluster binding;GO:0051538|3 iron, 4 sulfur cluster binding;GO:0051539|4 iron, 4 sulfur cluster binding;","K00235","SDHB, SDH2; succinate dehydrogenase (ubiquinone) iron-sulfur subunit [EC:1.3.5.1]"]
["ENSRNOG00000006082",1608,103.4433446,362,23.3713932,4.426066676,2.146025185,{"v":1.3724E-185,"d":"1.37E-185"},{"v":1.5131E-184,"d":"1.51E-184"},"up","yes","Rmdn2","protein_coding","chr6:15375496-15441480:-","gi|149050616|gb|EDM02789.1|",1979,0,"similar to hypothetical protein FLJ32954 [Rattus norvegicus]","gi|672055167|ref|XM_006239635.2|",1616,0,"PREDICTED: Rattus norvegicus regulator of microtubule dynamics 2 (Rmdn2), transcript variant X5, mRNA","Q498D5",749,0,"Regulator of microtubule dynamics protein 2",".",".",".",".","pfam04544","Herpes_UL20","Herpesvirus egress protein UL20. UL20 is predicted to be a transmembrane protein with multiple membrane spans. It is involved in the trans-cellular transport of enveloped virions, and is therefore important for viral egress. However, UL20 operates in different cellular compartments and different stages of egress in pseudorabies virus and herpes simplex virus. This is thought to be due to differences in egress pathways between these two viruses.",".","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005876|spindle microtubule;GO:0016021|integral component of membrane;GO:0072686|mitotic spindle;GO:0097431|mitotic spindle pole;","GO:0008017|microtubule binding;",".","."]
["ENSRNOG00000011923",1318,84.78751753,232,14.97835144,5.66067086,2.500973041,{"v":1.0248E-182,"d":"1.02E-182"},{"v":1.1256e-181,"d":"1.13E-181"},"up","yes","Mgarp","protein_coding","chr2:135431283-135439612:-","gi|157818123|ref|NP_001103026.1|",744,{"v":8e-93,"d":"8.00E-93"},"protein MGARP [Rattus norvegicus]","gi|157818122|ref|NM_001109556.1|",1161,0,"Rattus norvegicus mitochondria-localized glutamic acid-rich protein (Mgarp), mRNA","Q8VI64",207,{"v":8e-62,"d":"8.00E-62"},"Protein MGARP",".",".",".",".","pfam14962","AIF-MLS","Mitochondria Localisation Sequence. This family contains a protein found in eukaryotes. Proteins in this family are typically between 240 and 613 amino acids in length. The family is found in association with pfam07992. This protein family is an N-terminal domain for the mitochondrial localisation sequence for an apoptosis-inducing factor. The protein is also known as Corneal endothelium-specific protein 1 or as Ovary-specific acidic protein. It is thought to be important for membrane function and is expressed in the ovary and corneal endothelium.","GO:0006626|protein targeting to mitochondrion;GO:0008089|anterograde axonal transport;GO:0008090|retrograde axonal transport;GO:0010822|positive regulation of mitochondrion organization;GO:0019896|axonal transport of mitochondrion;GO:0071383|cellular response to steroid hormone stimulus;GO:0071456|cellular response to hypoxia;GO:0097211|cellular response to gonadotropin-releasing hormone;","GO:0005739|mitochondrion;GO:0031307|integral component of mitochondrial outer membrane;GO:1904115|axon cytoplasm;",".",".","."]
["ENSRNOG00000039091",2809,180.7042009,1047,67.59626706,2.673286688,1.418614563,{"v":2.4458E-182,"d":"2.45E-182"},{"v":2.676E-181,"d":"2.68E-181"},"up","yes","Pnpla8","protein_coding","chr6:61329810-61391734:+","gi|392340992|ref|XP_003754218.1|",3977,0,"PREDICTED: calcium-independent phospholipase A2-gamma [Rattus norvegicus]","gi|672020660|ref|XM_003754170.3|",4569,0,"PREDICTED: Rattus norvegicus patatin-like phospholipase domain containing 8 (Pnpla8), mRNA","Q8K1N1",1422,0,"Calcium-independent phospholipase A2-gamma","VC0178",63.9,1e-09,"COG3621","pfam01734","Patatin","Patatin-like phospholipase. This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein but it also has the enzymatic activity of lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have been found also in vertebrates.","GO:0001516|prostaglandin biosynthetic process;GO:0006631|fatty acid metabolic process;GO:0008219|cell death;GO:0016042|lipid catabolic process;GO:0019369|arachidonic acid metabolic process;GO:0032048|cardiolipin metabolic process;GO:0034638|phosphatidylcholine catabolic process;GO:0043651|linoleic acid metabolic process;GO:0046338|phosphatidylethanolamine catabolic process;GO:0050482|arachidonic acid secretion;GO:0055088|lipid homeostasis;GO:0070328|triglyceride homeostasis;GO:1900407|regulation of cellular response to oxidative stress;","GO:0005739|mitochondrion;GO:0005777|peroxisome;GO:0005778|peroxisomal membrane;GO:0005789|endoplasmic reticulum membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0031966|mitochondrial membrane;","GO:0004620|phospholipase activity;GO:0004622|lysophospholipase activity;GO:0016787|hydrolase activity;GO:0047499|calcium-independent phospholipase A2 activity;GO:0102545|phosphatidyl phospholipase B activity;","K16815","PNPLA8; calcium-independent phospholipase A2-gamma"]
["ENSRNOG00000000903",2118,136.2518681,640,41.31959018,3.297512572,1.72137816,{"v":2.9269e-182,"d":"2.93E-182"},{"v":3.1962e-181,"d":"3.20E-181"},"up","yes","Asl","protein_coding","chr12:26659565-26679662:+","gi|31377525|ref|NP_067588.2|",2465,0,"argininosuccinate lyase [Rattus norvegicus]","gi|148747348|ref|NM_021577.3|",2073,0,"Rattus norvegicus argininosuccinate lyase (Asl), mRNA","P20673",947,0,"Argininosuccinate lyase","SPBC1539.03c",566,0,"COG0165","pfam00206","Lyase_1","Lyase.","GO:0000050|urea cycle;GO:0000053|argininosuccinate metabolic process;GO:0001822|kidney development;GO:0001889|liver development;GO:0006520|cellular amino acid metabolic process;GO:0006526|arginine biosynthetic process;GO:0007494|midgut development;GO:0007568|aging;GO:0007584|response to nutrient;GO:0007626|locomotory behavior;GO:0009410|response to xenobiotic stimulus;GO:0009636|response to toxic substance;GO:0009791|post-embryonic development;GO:0010043|response to zinc ion;GO:0014075|response to amine;GO:0019676|ammonia assimilation cycle;GO:0032496|response to lipopolysaccharide;GO:0042450|arginine biosynthetic process via ornithine;GO:0043434|response to peptide hormone;GO:0048545|response to steroid hormone;GO:0060416|response to growth hormone;GO:0060539|diaphragm development;GO:0071242|cellular response to ammonium ion;GO:0071320|cellular response to cAMP;GO:0071346|cellular response to interferon-gamma;GO:0071356|cellular response to tumor necrosis factor;GO:0071377|cellular response to glucagon stimulus;GO:0071385|cellular response to glucocorticoid stimulus;GO:0071456|cellular response to hypoxia;GO:0071549|cellular response to dexamethasone stimulus;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005741|mitochondrial outer membrane;GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0048471|perinuclear region of cytoplasm;GO:0070852|cell body fiber;","GO:0004056|argininosuccinate lyase activity;GO:0042802|identical protein binding;","K01755","argH, ASL; argininosuccinate lyase [EC:4.3.2.1]"]
["ENSRNOG00000005101",2648,170.3470003,950,61.33376667,2.777377121,1.473723084,{"v":5.398e-182,"d":"5.40E-182"},{"v":5.8836e-181,"d":"5.88E-181"},"up","yes","Mia2","protein_coding","chr6:76787508-76885211:+","gi|672020746|ref|XP_008774469.1|",4231,0,"PREDICTED: cTAGE family member 5 isoform X1 [Rattus norvegicus]","gi|672020745|ref|XM_008776247.1|",2988,0,"PREDICTED: Rattus norvegicus cutaneous T-cell lymphoma-associated antigen 5 homolog (LOC100912115), transcript variant X1, mRNA","Q91ZV0",1963,0,"Melanoma inhibitory activity protein 2",".",".",".",".","pfam02463","SMC_N","RecF/RecN/SMC N terminal domain. This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics.   This family also includes the RecF and RecN proteins that are involved in DNA metabolizm and recombination.","GO:0006888|ER to Golgi vesicle-mediated transport;GO:0009306|protein secretion;GO:0032527|protein exit from endoplasmic reticulum;GO:0035459|cargo loading into vesicle;GO:0042632|cholesterol homeostasis;GO:0042953|lipoprotein transport;GO:0070328|triglyceride homeostasis;GO:0070973|protein localization to endoplasmic reticulum exit site;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0070971|endoplasmic reticulum exit site;","GO:0038024|cargo receptor activity;","K23703","MIA2, CTAGE5; melanoma inhibitory activity protein 2"]
["ENSRNOG00000016751",3561,229.0806904,1529,98.71508341,2.320624999,1.21451341,{"v":7.4459e-182,"d":"7.45E-182"},{"v":8.1002E-181,"d":"8.10E-181"},"up","yes","Slc25a28","protein_coding","chr1:242530899-242542115:-","gi|564334146|ref|XP_006231629.1|",1853,0,"PREDICTED: mitoferrin-2 isoform X1 [Rattus norvegicus]","gi|672040533|ref|XM_006231567.2|",1614,0,"PREDICTED: Rattus norvegicus solute carrier family 25 (mitochondrial iron transporter), member 28 (Slc25a28), transcript variant X1, mRNA","Q8R0Z5",620,0,"Mitoferrin-2",".",".",".",".","pfam00153","Mito_carr","Mitochondrial carrier protein.","GO:0048250|iron import into the mitochondrion;","GO:0005739|mitochondrion;GO:0016021|integral component of membrane;","GO:0005381|iron ion transmembrane transporter activity;GO:0015093|ferrous iron transmembrane transporter activity;","K15113","SLC25A28_37, MFRN; solute carrier family 25 (mitochondrial iron transporter), member 28/37"]
["ENSRNOG00000021931",2506,161.2120781,868,56.03969418,2.876747999,1.524438848,{"v":4.3183e-181,"d":"4.32E-181"},{"v":4.6799e-180,"d":"4.68E-180"},"up","yes","Uba6","protein_coding","chr14:21884039-21947857:+","gi|157821599|ref|NP_001100683.1|",5608,0,"ubiquitin-like modifier-activating enzyme 6 [Rattus norvegicus]","gi|157821598|ref|NM_001107213.1|",6567,0,"Rattus norvegicus ubiquitin-like modifier activating enzyme 6 (Uba6), mRNA","Q8C7R4",2105,0,"Ubiquitin-like modifier-activating enzyme 6","YKL210w",739,0,"COG0476","pfam09358","UBA_e1_C","Ubiquitin-activating enzyme e1 C-terminal domain. This presumed domain found at the C-terminus of Ubiquitin-activating enzyme e1 proteins is functionally uncharacterized.","GO:0006511|ubiquitin-dependent protein catabolic process;GO:0006974|cellular response to DNA damage stimulus;GO:0007612|learning;GO:0007626|locomotory behavior;GO:0016567|protein ubiquitination;GO:0021764|amygdala development;GO:0021766|hippocampus development;GO:0032446|protein modification by small protein conjugation;GO:0060996|dendritic spine development;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0004839|ubiquitin activating enzyme activity;GO:0005524|ATP binding;GO:0019780|FAT10 activating enzyme activity;","K10699","UBE1L2, UBA6; ubiquitin-activating enzyme E1-like protein 2 [EC:6.2.1.45]"]
["ENSRNOG00000065163",2484,159.7968085,855,55.20039001,2.894849265,1.533488229,{"v":4.5331e-181,"d":"4.53E-181"},{"v":4.9034E-180,"d":"4.90E-180"},"up","yes","ENSRNOG00000065163","lncRNA","chr3:36878660-36880280:-",".",".",".",".","gi|672045108|ref|XM_008761696.1|",1208,0,"PREDICTED: Rattus norvegicus ADP-ribosylation factor-like 5A (Arl5a), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam06211","BAMBI","BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain. This family consists of several eukaryotic BMP and activin membrane-bound inhibitor (BAMBI) proteins. Members of the transforming growth factor-beta (TGF-beta) superfamily, including TGF-beta, bone morphogenetic proteins (BMPs), activins and nodals, are vital for regulating growth and differentiation. BAMBI is related to TGF-beta-family type I receptors but lacks an intracellular kinase domain. BAMBI is co-expressed with the ventralising morphogen BMP4 during Xenopus embryogenesis and requires BMP signalling for its expression. The protein stably associates with TGF-beta-family receptors and inhibits BMP and activin as well as TGF-beta signalling.",".",".",".",".","."]
["ENSRNOG00000009946",3485,224.1915771,1486,95.93892345,2.336815643,1.224543921,{"v":2.5828e-180,"d":"2.58E-180"},{"v":2.7832E-179,"d":"2.78E-179"},"up","yes","Ldlr","protein_coding","chr8:20270041-20294580:+","gi|149020469|gb|EDL78274.1|",4436,0,"low density lipoprotein receptor, isoform CRA_a [Rattus norvegicus]","gi|31343479|ref|NM_175762.2|",3015,0,"Rattus norvegicus low density lipoprotein receptor (Ldlr), mRNA","P35952",1702,0,"Low-density lipoprotein receptor",".",".",".",".","pfam00057","Ldl_recept_a","Low-density lipoprotein receptor domain class A.","GO:0001666|response to hypoxia;GO:0006629|lipid metabolic process;GO:0006897|endocytosis;GO:0006898|receptor-mediated endocytosis;GO:0006909|phagocytosis;GO:0007568|aging;GO:0007616|long-term memory;GO:0008203|cholesterol metabolic process;GO:0009725|response to hormone;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010867|positive regulation of triglyceride biosynthetic process;GO:0010898|positive regulation of triglyceride catabolic process;GO:0010899|regulation of phosphatidylcholine catabolic process;GO:0015914|phospholipid transport;GO:0030299|intestinal cholesterol absorption;GO:0030301|cholesterol transport;GO:0032355|response to estradiol;GO:0033762|response to glucagon;GO:0034381|plasma lipoprotein particle clearance;GO:0034383|low-density lipoprotein particle clearance;GO:0034384|high-density lipoprotein particle clearance;GO:0042157|lipoprotein metabolic process;GO:0042159|lipoprotein catabolic process;GO:0042632|cholesterol homeostasis;GO:0043627|response to estrogen;GO:0045056|transcytosis;GO:0045471|response to ethanol;GO:0048844|artery morphogenesis;GO:0050729|positive regulation of inflammatory response;GO:0051246|regulation of protein metabolic process;GO:0051248|negative regulation of protein metabolic process;GO:0061771|response to caloric restriction;GO:0061889|negative regulation of astrocyte activation;GO:0070508|cholesterol import;GO:0071398|cellular response to fatty acid;GO:0071404|cellular response to low-density lipoprotein particle stimulus;GO:0090118|receptor-mediated endocytosis involved in cholesterol transport;GO:0090181|regulation of cholesterol metabolic process;GO:0097242|amyloid-beta clearance;GO:0150094|amyloid-beta clearance by cellular catabolic process;GO:1903979|negative regulation of microglial cell activation;GO:1905167|positive regulation of lysosomal protein catabolic process;GO:1905907|negative regulation of amyloid fibril formation;","GO:0005764|lysosome;GO:0005768|endosome;GO:0005769|early endosome;GO:0005770|late endosome;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005901|caveola;GO:0005905|clathrin-coated pit;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0034362|low-density lipoprotein particle;GO:0036477|somatodendritic compartment;GO:0043235|receptor complex;GO:0045177|apical part of cell;GO:0055038|recycling endosome membrane;GO:0097443|sorting endosome;GO:1990666|PCSK9-LDLR complex;","GO:0001540|amyloid-beta binding;GO:0002020|protease binding;GO:0005041|low-density lipoprotein particle receptor activity;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0030169|low-density lipoprotein particle binding;GO:0030229|very-low-density lipoprotein particle receptor activity;GO:0042802|identical protein binding;GO:0071813|lipoprotein particle binding;","K12473","LDLR; low-density lipoprotein receptor"]
["ENSRNOG00000018028",1010,64.97374257,109,7.037242702,9.232840946,3.206774634,{"v":2.8472E-180,"d":"2.85E-180"},{"v":3.0623E-179,"d":"3.06E-179"},"up","yes","Testin","protein_coding","chr17:3846899-3859385:+","gi|27465595|ref|NP_775155.1|",1819,0,"testin-2 precursor [Rattus norvegicus]","gi|402693052|ref|NM_173132.2|",1358,0,"Rattus norvegicus testin gene (Testin), mRNA","P15242",705,0,"Testin-2","AF1946_2",72,{"v":2e-13,"d":"2.00E-13"},"COG4870","pfam00112","Peptidase_C1","Papain family cysteine protease.","GO:0006955|immune response;GO:0051603|proteolysis involved in cellular protein catabolic process;","GO:0005615|extracellular space;GO:0005764|lysosome;GO:0030054|cell junction;","GO:0004197|cysteine-type endopeptidase activity;","K24271","Testin; testin-2"]
["ENSRNOG00000005437",3018,194.1492624,1188,76.69948927,2.531297982,1.33987735,{"v":1.2507E-179,"d":"1.25E-179"},{"v":1.3426e-178,"d":"1.34E-178"},"up","yes","Rida","protein_coding","chr7:65691435-65705716:-","gi|1709863|sp|P52759.3|UK114_RAT",686,{"v":2E-85,"d":"2.00E-85"},"RecName: Full=Ribonuclease UK114; AltName: Full=14.5 kDa translational inhibitor protein; AltName: Full=Perchloric acid soluble protein","gi|298903314|emb|FQ209529.1|",907,0,"Rattus norvegicus TL0ABA42YC10 mRNA sequence","P52759",268,{"v":6e-87,"d":"6.00E-87"},"2-iminobutanoate/2-iminopropanoate deaminase","lin0837",127,{"v":4e-34,"d":"4.00E-34"},"COG0251","pfam01042","Ribonuc_L-PSP","Endoribonuclease L-PSP. Endoribonuclease active on single-stranded mRNA. Inhibits protein synthesis by cleavage of mRNA. Previously thought to inhibit protein synthesis initiation. This protein may also be involved in the regulation of purine biosynthesis. YjgF (renamed RidA) family members are enamine/imine deaminases. They hydrolyze reactive intermediates released by PLP-dependent enzymes, including threonine dehydratase. YjgF also prevents inhibition of transaminase B (IlvE) in Salmonella.","GO:0001822|kidney development;GO:0006402|mRNA catabolic process;GO:0007420|brain development;GO:0017148|negative regulation of translation;GO:0030324|lung development;GO:0033993|response to lipid;GO:0050680|negative regulation of epithelial cell proliferation;GO:0061157|mRNA destabilization;GO:0070314|G1 to G0 transition;GO:0090502|RNA phosphodiester bond hydrolysis, endonucleolytic;GO:1901565|organonitrogen compound catabolic process;GO:1902074|response to salt;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005759|mitochondrial matrix;GO:0005777|peroxisome;GO:0005829|cytosol;","GO:0003729|mRNA binding;GO:0016892|endoribonuclease activity, producing 3'-phosphomonoesters;GO:0019239|deaminase activity;GO:0036041|long-chain fatty acid binding;GO:0042802|identical protein binding;GO:0043167|ion binding;GO:0046914|transition metal ion binding;","K09022","ridA, tdcF, RIDA; 2-iminobutanoate/2-iminopropanoate deaminase [EC:3.5.99.10]"]
["ENSRNOG00000030334",3276,210.7465155,1355,87.48131983,2.409045907,1.268461886,{"v":3.8483E-179,"d":"3.85E-179"},{"v":4.1236e-178,"d":"4.12E-178"},"up","yes","Adck5","protein_coding","chr7:108301415-108319436:+","gi|209447056|ref|NP_001129270.1|",2951,0,"uncharacterized aarF domain-containing protein kinase 5 [Rattus norvegicus]","gi|209447055|ref|NM_001135798.1|",1991,0,"Rattus norvegicus aarF domain containing kinase 5 (Adck5), mRNA","Q80V03",1088,0,"Uncharacterized aarF domain-containing protein kinase 5","SPAC10F6.14c",197,{"v":1E-53,"d":"1.00E-53"},"COG0661","pfam03109","ABC1","ABC1 family. This family includes ABC1 from yeast and AarF from Escherichia coli. These proteins have a nuclear or mitochondrial subcellular location in eukaryotes. The exact molecular functions of these proteins is not clear, however yeast ABC1 suppresses a cytochrome b mRNA translation defect and is essential for the electron transfer in the bc 1 complex and Escherichia coli AarF is required for ubiquinone production. It has been suggested that members of the ABC1 family are novel chaperonins. These proteins are unrelated to the ABC transporter proteins.",".","GO:0016021|integral component of membrane;",".","K08869","ADCK, ABC1; aarF domain-containing kinase"]
["ENSRNOG00000049768",2352,151.3051906,784,50.61649797,2.989246524,1.579781881,{"v":4.4154E-179,"d":"4.42E-179"},{"v":4.7224e-178,"d":"4.72E-178"},"up","yes","Adcy9","protein_coding","chr10:11139446-11262066:+","gi|672024526|ref|XP_008772839.1|",6755,0,"PREDICTED: adenylate cyclase type 9 isoform X1 [Rattus norvegicus]","gi|672066721|ref|XM_008767525.1|",7343,0,"PREDICTED: Rattus norvegicus adenylate cyclase 9 (Adcy9), transcript variant X1, mRNA","P51830",2456,0,"Adenylate cyclase type 9","all0661",160,{"v":4e-40,"d":"4.00E-40"},"COG2114","pfam00211","Guanylate_cyc","Adenylate and Guanylate cyclase catalytic domain.","GO:0001701|in utero embryonic development;GO:0006171|cAMP biosynthetic process;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0035556|intracellular signal transduction;GO:0071880|adenylate cyclase-activating adrenergic receptor signaling pathway;","GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0030425|dendrite;","GO:0004016|adenylate cyclase activity;","K08049","ADCY9; adenylate cyclase 9 [EC:4.6.1.1]"]
["ENSRNOG00000020196",1463,94.11543106,310,20.01417649,4.702438349,2.23340903,{"v":1.6126E-177,"d":"1.61E-177"},{"v":1.7087E-176,"d":"1.71E-176"},"up","yes","Scgb1a1","protein_coding","chr1:205977060-205980610:-","gi|6981694|ref|NP_037183.1|",420,{"v":3e-50,"d":"3.00E-50"},"uteroglobin precursor [Rattus norvegicus]","gi|6981693|ref|NM_013051.1|",454,0,"Rattus norvegicus secretoglobin family 1A member 1 (Scgb1a1), mRNA","P17559",166,{"v":1E-51,"d":"1.00E-51"},"Uteroglobin",".",".",".",".","pfam01099","Uteroglobin","Uteroglobin family. Uteroglobin is a homodimer of two identical 70 amino acid polypeptides linked by two disulphide bridges. The precise role of uteroglobin has still to be elucidated.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0007165|signal transduction;GO:0009410|response to xenobiotic stimulus;GO:0010033|response to organic substance;GO:0010193|response to ozone;GO:0032496|response to lipopolysaccharide;GO:0032689|negative regulation of interferon-gamma production;GO:0032696|negative regulation of interleukin-13 production;GO:0032713|negative regulation of interleukin-4 production;GO:0032714|negative regulation of interleukin-5 production;GO:0034021|response to silicon dioxide;GO:0034097|response to cytokine;GO:0042130|negative regulation of T cell proliferation;GO:0043086|negative regulation of catalytic activity;GO:0043488|regulation of mRNA stability;GO:0050727|regulation of inflammatory response;GO:0051384|response to glucocorticoid;GO:0071774|response to fibroblast growth factor;","GO:0005615|extracellular space;GO:0005635|nuclear envelope;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005791|rough endoplasmic reticulum;GO:0030141|secretory granule;","GO:0019834|phospholipase A2 inhibitor activity;GO:0097160|polychlorinated biphenyl binding;","K25464","SCGB1A, CC10; secretoglobin family 1A (uteroglobin)"]
["ENSRNOG00000069673",2350,151.1765297,792,51.13299285,2.956535914,1.563907802,{"v":2.3757e-176,"d":"2.38E-176"},{"v":2.5034E-175,"d":"2.50E-175"},"up","yes","Pnpla2","protein_coding","chr1:196552723-196557805:+","gi|189095277|ref|NP_001101979.2|",2045,0,"patatin-like phospholipase domain-containing protein 2 [Rattus norvegicus]","gi|189095276|ref|NM_001108509.2|",2231,0,"Rattus norvegicus patatin-like phospholipase domain containing 2 (Pnpla2), mRNA","P0C548",792,0,"Patatin-like phospholipase domain-containing protein 2",".",".",".",".","pfam01734","Patatin","Patatin-like phospholipase. This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein but it also has the enzymatic activity of lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have been found also in vertebrates.",".",".",".",".","."]
["ENSRNOG00000046502",3602,231.7182383,1585,102.3305476,2.264409249,1.179134722,{"v":1.3408e-175,"d":"1.34E-175"},{"v":1.3999e-174,"d":"1.40E-174"},"up","yes","Lonp1","protein_coding","chr9:1447447-1459771:-","gi|19173766|ref|NP_596895.1|",4681,0,"lon protease homolog, mitochondrial precursor [Rattus norvegicus]","gi|19173765|ref|NM_133404.1|",2952,0,"Rattus norvegicus lon peptidase 1, mitochondrial (Lonp1), mRNA","Q924S5",1807,0,"Lon protease homolog, mitochondrial","SPAC22F3.06c",745,0,"COG0466","pfam05362","Lon_C","Lon protease (S16) C-terminal proteolytic domain. The Lon serine proteases must hydrolyse ATP to degrade protein substrates. In Escherichia coli, these proteases are involved in turnover of intracellular proteins, including abnormal proteins following heat-shock. The active site for protease activity resides in a C-terminal domain. The Lon proteases are classified as family S16 in Merops.","GO:0001666|response to hypoxia;GO:0006508|proteolysis;GO:0006515|protein quality control for misfolded or incompletely synthesized proteins;GO:0007005|mitochondrion organization;GO:0007568|aging;GO:0009725|response to hormone;GO:0010044|response to aluminum ion;GO:0034599|cellular response to oxidative stress;GO:0034622|cellular protein-containing complex assembly;GO:0051131|chaperone-mediated protein complex assembly;GO:0051603|proteolysis involved in cellular protein catabolic process;GO:0070407|oxidation-dependent protein catabolic process;","GO:0005654|nucleoplasm;GO:0005739|mitochondrion;GO:0005759|mitochondrial matrix;GO:0005829|cytosol;GO:0042645|mitochondrial nucleoid;","GO:0001018|mitochondrial promoter sequence-specific DNA binding;GO:0003697|single-stranded DNA binding;GO:0003727|single-stranded RNA binding;GO:0004176|ATP-dependent peptidase activity;GO:0004252|serine-type endopeptidase activity;GO:0005524|ATP binding;GO:0016887|ATPase activity;GO:0042802|identical protein binding;GO:0043531|ADP binding;GO:0043565|sequence-specific DNA binding;GO:0051880|G-quadruplex DNA binding;GO:0070182|DNA polymerase binding;","K08675","PRSS15, PIM1; ATP-dependent Lon protease [EC:3.4.21.53]"]
["ENSRNOG00000002669",3879,249.5377697,1774,114.532739,2.178746198,1.123498147,{"v":4.9658e-175,"d":"4.97E-175"},{"v":5.1755e-174,"d":"5.18E-174"},"up","yes","Cluh","protein_coding","chr10:59509726-59531345:+","gi|764020083|ref|NP_001292142.1|",6983,0,"clustered mitochondria (cluA/CLU1) homolog [Rattus norvegicus]","gi|764020082|ref|NM_001305213.1|",5339,0,"Rattus norvegicus clustered mitochondria (cluA/CLU1) homolog (Cluh), mRNA","Q5SW19",2545,0,"Clustered mitochondria protein homolog",".",".",".",".","pfam13236","CLU","Clustered mitochondria. The CLU domain (CLUstered mitochondria) is a eukaryotic domain found in proteins from fungi, protozoa, plants to humans. It is required for correct functioning of the mitochondria and mitochondrial transport although the exact function of the domain is unknown. In Dictyostelium the full-length protein is required for a very late step in fission of the outer mitochondrial membrane suggesting that mitochondria are transported along microtubules, as in mammalian cells, rather than along actin filaments, as in budding yeast. Disruption of the protein-impaired cytokinesis and caused mitochondria to cluster at the cell centre. It is likely that CLU functions in a novel pathway that positions mitochondria within the cell based on their physiological state. Disruption of the CLU pathway may enhance oxidative damage, alter gene expression, cause mitochondria to cluster at microtubule plus ends, and lead eventually to mitochondrial failure.","GO:0007005|mitochondrion organization;GO:0048312|intracellular distribution of mitochondria;","GO:0005737|cytoplasm;","GO:0003729|mRNA binding;","K03255","TIF31, CLU1; protein TIF31"]
["ENSRNOG00000020897",4453,286.4634412,2172,140.2283592,2.042835293,1.030572889,{"v":1.3041E-174,"d":"1.30E-174"},{"v":1.3518E-173,"d":"1.35E-173"},"up","yes","Prpf19","protein_coding","chr1:207541595-207552662:+","gi|359718922|ref|NP_001240773.1|",1868,0,"pre-mRNA-processing factor 19 isoform 3 [Mus musculus]","gi|672039671|ref|XM_006231014.2|",1450,0,"PREDICTED: Rattus norvegicus pre-mRNA processing factor 19 (Prpf19), transcript variant X2, mRNA","Q9JMJ4",723,0,"Pre-mRNA-processing factor 19",".",".",".",".","pfam08606","Prp19","Prp19/Pso4-like. This regions is found specifically in PRP19-like protein.  The region represented by this family covers the sequence implicated in self-interaction and a coiled-coiled motif. PRP19-like proteins form an oligomer that is necessary for spliceosome assembly.","GO:0000077|DNA damage checkpoint;GO:0000209|protein polyubiquitination;GO:0000244|spliceosomal tri-snRNP complex assembly;GO:0000245|spliceosomal complex assembly;GO:0000349|generation of catalytic spliceosome for first transesterification step;GO:0000398|mRNA splicing, via spliceosome;GO:0001833|inner cell mass cell proliferation;GO:0006303|double-strand break repair via nonhomologous end joining;GO:0008610|lipid biosynthetic process;GO:0010498|proteasomal protein catabolic process;GO:0034613|cellular protein localization;GO:0045665|negative regulation of neuron differentiation;GO:0045666|positive regulation of neuron differentiation;GO:0048026|positive regulation of mRNA splicing, via spliceosome;GO:0048711|positive regulation of astrocyte differentiation;GO:0070534|protein K63-linked ubiquitination;","GO:0000974|Prp19 complex;GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005811|lipid droplet;GO:0005819|spindle;GO:0016607|nuclear speck;GO:0035861|site of double-strand break;GO:0071006|U2-type catalytic step 1 spliceosome;GO:0071007|U2-type catalytic step 2 spliceosome;GO:0071013|catalytic step 2 spliceosome;","GO:0003674|molecular_function;GO:0004842|ubiquitin-protein transferase activity;GO:0005515|protein binding;GO:0034450|ubiquitin-ubiquitin ligase activity;GO:0042802|identical protein binding;GO:0061630|ubiquitin protein ligase activity;","K10599","PRPF19, PRP19; pre-mRNA-processing factor 19 [EC:2.3.2.27]"]
["ENSRNOG00000010186",4053,260.731266,1902,122.7966571,2.123276579,1.08629231,{"v":3.2701E-173,"d":"3.27E-173"},{"v":3.3591e-172,"d":"3.36E-172"},"up","yes","Cdv3","protein_coding","chr8:103933996-103947192:-","gi|564365223|ref|XP_006243721.1|",707,{"v":2e-81,"d":"2.00E-81"},"PREDICTED: protein CDV3 homolog isoform X3 [Rattus norvegicus]","gi|672063010|ref|XM_006243659.2|",3211,0,"PREDICTED: Rattus norvegicus carnitine deficiency-associated gene expressed in ventricle 3 homolog (mouse) (Cdv3), transcript variant X3, mRNA","Q4VAA2",263,{"v":3e-78,"d":"3.00E-78"},"Protein CDV3",".",".",".",".","pfam15359","CDV3","Carnitine deficiency-associated protein 3. This family of proteins is found in eukaryotes. Proteins in this family are typically between 128 and 251 amino acids in length. CDV3 is also known as TPP36 - tyrosine-phosphorylated protein 36. The function is not known.",".","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;",".",".","."]
["ENSRNOG00000020254",2525,162.4343564,908,58.62216857,2.770869116,1.470338566,{"v":4.7603E-173,"d":"4.76E-173"},{"v":4.881e-172,"d":"4.88E-172"},"up","yes","Per2","protein_coding","chr9:92007296-92049459:-","gi|13928942|ref|NP_113866.1|",5815,0,"period circadian protein homolog 2 [Rattus norvegicus]","gi|13928941|ref|NM_031678.1|",5751,0,"Rattus norvegicus period circadian clock 2 (Per2), mRNA","Q9Z301",2244,0,"Period circadian protein homolog 2",".",".",".",".","pfam12114","Period_C","Period protein 2/3C-terminal region. This domain is found in eukaryotes. This domain is typically between 164 to 200 amino acids in length. This domain is found associated with pfam08447.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0002931|response to ischemia;GO:0005978|glycogen biosynthetic process;GO:0006094|gluconeogenesis;GO:0006631|fatty acid metabolic process;GO:0007623|circadian rhythm;GO:0019229|regulation of vasoconstriction;GO:0019249|lactate biosynthetic process;GO:0031397|negative regulation of protein ubiquitination;GO:0032922|circadian regulation of gene expression;GO:0042752|regulation of circadian rhythm;GO:0042754|negative regulation of circadian rhythm;GO:0043153|entrainment of circadian clock by photoperiod;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0050767|regulation of neurogenesis;GO:0050796|regulation of insulin secretion;GO:0050872|white fat cell differentiation;GO:0051726|regulation of cell cycle;GO:0051946|regulation of glutamate uptake involved in transmission of nerve impulse;GO:0060567|negative regulation of DNA-templated transcription, termination;GO:0070345|negative regulation of fat cell proliferation;GO:0070932|histone H3 deacetylation;GO:0097167|circadian regulation of translation;GO:0120162|positive regulation of cold-induced thermogenesis;GO:2000678|negative regulation of transcription regulatory region DNA binding;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0048471|perinuclear region of cytoplasm;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001222|transcription corepressor binding;GO:0003713|transcription coactivator activity;GO:0005515|protein binding;GO:0016922|nuclear receptor binding;GO:0019900|kinase binding;GO:0036002|pre-mRNA binding;GO:0042802|identical protein binding;GO:0042826|histone deacetylase binding;GO:0070063|RNA polymerase binding;GO:1990226|histone methyltransferase binding;","K02633","PER2; period circadian protein 2"]
["ENSRNOG00000018812",1930,124.1577457,564,36.41288885,3.409719735,1.76965316,{"v":1.0068e-172,"d":"1.01E-172"},{"v":1.0286E-171,"d":"1.03E-171"},"up","yes","Rpp25","protein_coding","chr8:57907352-57908732:+","gi|478495071|ref|XP_004421883.1|",772,{"v":3e-97,"d":"3.00E-97"},"PREDICTED: ribonuclease P protein subunit p25 [Ceratotherium simum simum]","gi|58865817|ref|NM_001012124.1|",1381,0,"Rattus norvegicus ribonuclease P/MRP 25 subunit (Rpp25), mRNA","Q5PPN2",287,{"v":3e-93,"d":"3.00E-93"},"Ribonuclease P protein subunit p25",".",".",".",".","pfam01918","Alba","Alba. Alba is a novel chromosomal protein that coats archaeal DNA without compacting it.","GO:0001682|tRNA 5'-leader removal;GO:0006364|rRNA processing;GO:0008150|biological_process;GO:0090502|RNA phosphodiester bond hydrolysis, endonucleolytic;","GO:0000172|ribonuclease MRP complex;GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0030681|multimeric ribonuclease P complex;GO:0034451|centriolar satellite;","GO:0003674|molecular_function;GO:0003723|RNA binding;GO:0004526|ribonuclease P activity;GO:0033204|ribonuclease P RNA binding;","K14525","RPP25; ribonucleases P/MRP protein subunit RPP25 [EC:3.1.26.5]"]
["ENSRNOG00000014087",2127,136.830842,681,43.96662643,3.112152402,1.637912711,{"v":1.0358e-170,"d":"1.04E-170"},{"v":1.0471e-169,"d":"1.05E-169"},"up","yes","Kifc3","protein_coding","chr19:9886693-9920451:+","gi|672084101|ref|XP_008770509.1|",3740,0,"PREDICTED: kinesin-like protein KIFC3 isoform X5 [Rattus norvegicus]","gi|672084099|ref|XM_006255088.2|",2831,0,"PREDICTED: Rattus norvegicus kinesin family member C3 (Kifc3), transcript variant X4, mRNA","O35231",1436,0,"Kinesin-like protein KIFC3","SPAC664.10",257,{"v":7e-70,"d":"7.00E-70"},"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0007017|microtubule-based process;GO:0007018|microtubule-based movement;GO:0007030|Golgi organization;GO:0045218|zonula adherens maintenance;GO:0090136|epithelial cell-cell adhesion;","GO:0005794|Golgi apparatus;GO:0005813|centrosome;GO:0005871|kinesin complex;GO:0005874|microtubule;GO:0005915|zonula adherens;","GO:0005524|ATP binding;GO:0008017|microtubule binding;GO:0008569|ATP-dependent microtubule motor activity, minus-end-directed;GO:0042802|identical protein binding;","K10406","KIFC2_3; kinesin family member C2/C3"]
["ENSRNOG00000028993",4250,273.4043623,2054,132.6100597,2.061716606,1.04384604,{"v":3.0851e-170,"d":"3.09E-170"},{"v":3.1131e-169,"d":"3.11E-169"},"up","yes","Rpl12","protein_coding","chrX:1196729-1197226:-","gi|157822227|ref|NP_001102668.1|",863,{"v":3e-116,"d":"3.00E-116"},"60S ribosomal protein L12 [Rattus norvegicus]","gi|672086899|ref|XM_006256635.2|",498,0,"PREDICTED: Rattus norvegicus 60S ribosomal protein L12-like (LOC102555453), mRNA","P23358",337,{"v":1E-117,"d":"1.00E-117"},"60S ribosomal protein L12","SPCC31H12.04c",254,{"v":9e-86,"d":"9.00E-86"},"COG0080","pfam03946","Ribosomal_L11_N","Ribosomal protein L11, N-terminal domain. The N-terminal domain of Ribosomal protein L11 adopts an alpha/beta fold and is followed by the RNA binding C-terminal domain.",".",".",".","K02870","RP-L12e, RPL12; large subunit ribosomal protein L12e"]
["ENSRNOG00000022681",1857,119.4616237,533,34.4114712,3.471563974,1.795585758,{"v":1.3286e-169,"d":"1.33E-169"},{"v":1.3383e-168,"d":"1.34E-168"},"up","yes","Bbln","protein_coding","chr3:15674580-15677374:-","gi|37574084|ref|NP_932118.1|",433,{"v":2E-51,"d":"2.00E-51"},"UPF0184 protein C9orf16 homolog [Mus musculus]","gi|672045380|ref|XM_575113.6|",662,0,"PREDICTED: Rattus norvegicus similar to Hypothetical UPF0184 protein C9orf16 homolog (RGD1561113), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam03670","UPF0184","Uncharacterized protein family (UPF0184).",".",".",".",".","."]
["ENSRNOG00000003905",2282,146.8020599,778,50.22912681,2.922648058,1.547276112,{"v":1.1031e-168,"d":"1.10E-168"},{"v":1.1014E-167,"d":"1.10E-167"},"up","yes","Nsf","protein_coding","chr10:88727912-88857386:-","gi|149054471|gb|EDM06288.1|",3731,0,"N-ethylmaleimide sensitive fusion protein, isoform CRA_b [Rattus norvegicus]","gi|298892762|emb|FQ211783.1|",3734,0,"Rattus norvegicus TL0AAA80YC15 mRNA sequence","P46460",1437,0,"Vesicle-fusing ATPase","SPAC1834.11c",660,0,"COG0464","pfam00004","AAA","ATPase family associated with various cellular activities (AAA). AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.","GO:0001921|positive regulation of receptor recycling;GO:0002090|regulation of receptor internalization;GO:0006813|potassium ion transport;GO:0006886|intracellular protein transport;GO:0006891|intra-Golgi vesicle-mediated transport;GO:0015031|protein transport;GO:0016192|vesicle-mediated transport;GO:0017157|regulation of exocytosis;GO:0032984|protein-containing complex disassembly;GO:0035494|SNARE complex disassembly;GO:0043001|Golgi to plasma membrane protein transport;GO:0045732|positive regulation of protein catabolic process;GO:0048211|Golgi vesicle docking;","GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005795|Golgi stack;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0043198|dendritic shaft;","GO:0000149|SNARE binding;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0008022|protein C-terminus binding;GO:0016887|ATPase activity;GO:0017075|syntaxin-1 binding;GO:0019901|protein kinase binding;GO:0019905|syntaxin binding;GO:0030165|PDZ domain binding;GO:0031267|small GTPase binding;GO:0031748|D1 dopamine receptor binding;GO:0035255|ionotropic glutamate receptor binding;GO:0043008|ATP-dependent protein binding;GO:0044877|protein-containing complex binding;GO:0046872|metal ion binding;","K06027","NSF, SEC18; vesicle-fusing ATPase [EC:3.6.4.6]"]
["ENSRNOG00000009550",1846,118.7539889,530,34.21778562,3.470534015,1.795157669,{"v":1.4814e-168,"d":"1.48E-168"},{"v":1.4766E-167,"d":"1.48E-167"},"up","yes","Sqle","protein_coding","chr7:90868011-90883618:+","gi|8394354|ref|NP_058832.1|",2800,0,"squalene monooxygenase [Rattus norvegicus]","gi|666018|dbj|D37920.1|RATSE",2171,0,"Rattus norvegicus mRNA for squalene epoxidase, complete cds","P52020",1083,0,"Squalene monooxygenase","SPBC713.12",323,{"v":3e-99,"d":"3.00E-99"},"COG0654","pfam08491","SE","Squalene epoxidase. This domain is found in squalene epoxidase (SE) and related proteins which are found in taxonomically diverse groups of eukaryotes and also in bacteria.  SE was first cloned from Saccharomyces cerevisiae where it was named ERG1. It contains a putative FAD binding site and is a key enzyme in the sterol biosynthetic pathway. Putative transmembrane regions are found to the protein's C-terminus.","GO:0006725|cellular aromatic compound metabolic process;GO:0008203|cholesterol metabolic process;GO:0010033|response to organic substance;GO:0016126|sterol biosynthetic process;GO:0042127|regulation of cell proliferation;GO:0140042|lipid droplet formation;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0004506|squalene monooxygenase activity;GO:0071949|FAD binding;","K00511","SQLE, ERG1; squalene monooxygenase [EC:1.14.14.17]"]
["ENSRNOG00000008116",3701,238.0869517,1688,108.9804191,2.184676419,1.127419612,{"v":5.0871e-168,"d":"5.09E-168"},{"v":5.0529e-167,"d":"5.05E-167"},"up","yes","Plpp3","protein_coding","chr5:119927085-120002205:+","gi|48675867|ref|NP_620260.2|",1296,{"v":2e-158,"d":"2.00E-158"},"phospholipid phosphatase 3 [Rattus norvegicus]","gi|48675866|ref|NM_138905.2|",1232,0,"Rattus norvegicus phospholipid phosphatase 3 (Plpp3), mRNA","P97544",503,{"v":7e-160,"d":"7.00E-160"},"Phospholipid phosphatase 3","ECU10g1440",66.2,{"v":1E-10,"d":"1.00E-10"},"COG0671","pfam01569","PAP2","PAP2 superfamily. This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidizing halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.","GO:0001568|blood vessel development;GO:0001702|gastrulation with mouth forming second;GO:0001933|negative regulation of protein phosphorylation;GO:0006644|phospholipid metabolic process;GO:0006670|sphingosine metabolic process;GO:0006672|ceramide metabolic process;GO:0006890|retrograde vesicle-mediated transport, Golgi to ER;GO:0007155|cell adhesion;GO:0007165|signal transduction;GO:0007229|integrin-mediated signaling pathway;GO:0016311|dephosphorylation;GO:0030111|regulation of Wnt signaling pathway;GO:0033631|cell-cell adhesion mediated by integrin;GO:0034109|homotypic cell-cell adhesion;GO:0044328|canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration;GO:0044329|canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion;GO:0044330|canonical Wnt signaling pathway involved in positive regulation of wound healing;GO:0046839|phospholipid dephosphorylation;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050821|protein stabilization;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0060020|Bergmann glial cell differentiation;GO:0060070|canonical Wnt signaling pathway;GO:0098609|cell-cell adhesion;GO:1902068|regulation of sphingolipid mediated signaling pathway;","GO:0000139|Golgi membrane;GO:0005789|endoplasmic reticulum membrane;GO:0005794|Golgi apparatus;GO:0005802|trans-Golgi network;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0033116|endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0045121|membrane raft;GO:0070971|endoplasmic reticulum exit site;","GO:0005178|integrin binding;GO:0008195|phosphatidate phosphatase activity;GO:0042392|sphingosine-1-phosphate phosphatase activity;GO:0042577|lipid phosphatase activity;","K01080","PLPP1_2_3; phosphatidate phosphatase [EC:3.1.3.4]"]
["ENSRNOG00000043171",2928,188.359523,1188,76.69948927,2.455811959,1.296200098,{"v":9.6049e-166,"d":"9.60E-166"},{"v":9.4093e-165,"d":"9.41E-165"},"up","yes","Hdhd2","protein_coding","chr18:70474926-70526470:+","gi|148540175|ref|NP_001014173.2|",1872,0,"haloacid dehalogenase-like hydrolase domain-containing protein 2 precursor [Rattus norvegicus]","gi|672083511|ref|XM_006254966.2|",1594,0,"PREDICTED: Rattus norvegicus haloacid dehalogenase-like hydrolase domain containing 2 (Hdhd2), transcript variant X2, mRNA","Q6AYR6",423,{"v":1e-140,"d":"1.00E-140"},"Haloacid dehalogenase-like hydrolase domain-containing protein 2","Rv1225c",96.7,{"v":7e-21,"d":"7.00E-21"},"COG0647","pfam08571","Yos1","Yos1-like. In yeast, Yos1 is a subunit of the Yip1p-Yif1p complex and is required for transport between the endoplasmic reticulum and the Golgi complex. Yos1 appears to be conserved in eukaryotes.","GO:0003331|positive regulation of extracellular matrix constituent secretion;GO:0007420|brain development;GO:0015031|protein transport;GO:0016311|dephosphorylation;GO:0035265|organ growth;GO:0050714|positive regulation of protein secretion;GO:2000269|regulation of fibroblast apoptotic process;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0016791|phosphatase activity;GO:0019899|enzyme binding;GO:0046872|metal ion binding;",".","."]
["ENSRNOG00000010895",3683,236.9290038,1692,109.2386665,2.168911534,1.116971209,{"v":9.3921e-165,"d":"9.39E-165"},{"v":9.1694e-164,"d":"9.17E-164"},"up","yes","Tmem30a","protein_coding","chr8:80729619-80753248:-","gi|51948472|ref|NP_001004248.1|",1586,0,"cell cycle control protein 50A [Rattus norvegicus]","gi|51948471|ref|NM_001004248.1|",1753,0,"Rattus norvegicus transmembrane protein 30A (Tmem30a), mRNA","Q6AY41",615,0,"Cell cycle control protein 50A","YCR094w",154,{"v":3e-40,"d":"3.00E-40"},"COG5035","pfam03381","CDC50","LEM3 (ligand-effect modulator 3) family / CDC50 family. Members of this family have been predicted to contain transmembrane helices. The family member LEM3 is a ligand-effect modulator, mutation of which increases glucocorticoid receptor activity in response to dexamethasone and also confers increased activity on other intracellular receptors including the progesterone, oestrogen and mineralocorticoid receptors. LEM3 is thought to affect a downstream step in the glucocorticoid receptor pathway. Factors that modulate ligand responsiveness are likely to contribute to the context-specific actions of the glucocorticoid receptor in mammalian cells. The products of genes YNR048w, YNL323w and YCR094w (CDC50) show redundancy of function and are involved in regulation of transcription via CDC39. CDC39 (also known as NOT1) is normally a negative regulator of transcription either by affecting the general RNA polymerase II machinery or by altering chromatin structure. One function of CDC39 is to block activation of the mating response pathway in the absence of pheromone, and mutation causes arrest in G1 by activation of the pathway. It may be that the cold-sensitive arrest in G1 noticed in CDC50 mutants may be due to inactivation of CDC39. The effects of LEM3 on glucocorticoid receptor activity may also be due to effects on transcription via CDC39.","GO:0006855|drug transmembrane transport;GO:0010976|positive regulation of neuron projection development;GO:0015917|aminophospholipid transport;GO:0036010|protein localization to endosome;GO:0045332|phospholipid translocation;GO:0061092|positive regulation of phospholipid translocation;GO:0070863|positive regulation of protein exit from endoplasmic reticulum;","GO:0001750|photoreceptor outer segment;GO:0001917|photoreceptor inner segment;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0030658|transport vesicle membrane;GO:1990531|phospholipid-translocating ATPase complex;","GO:0015247|aminophospholipid transmembrane transporter activity;",".","."]
["ENSRNOG00000008694",694,44.6453241,9,0.581056737,76.83470695,6.263686232,{"v":5.2148e-164,"d":"5.21E-164"},{"v":5.0825e-163,"d":"5.08E-163"},"up","yes","Miox","protein_coding","chr7:120405031-120407537:+","gi|56090638|ref|NP_665714.2|",1415,0,"inositol oxygenase [Rattus norvegicus]","gi|298906354|emb|FQ219187.1|",1010,0,"Rattus norvegicus TL0ABA47YA19 mRNA sequence","Q9QXN4",549,0,"Inositol oxygenase",".",".",".",".","pfam05153","DUF706","Family of unknown function (DUF706). Family of uncharacterized eukaryotic function. Some members have a described putative function, but a common theme is not evident.","GO:0019310|inositol catabolic process;","GO:0005737|cytoplasm;GO:0016234|inclusion body;","GO:0004033|aldo-keto reductase (NADP) activity;GO:0008199|ferric iron binding;GO:0016651|oxidoreductase activity, acting on NAD(P)H;GO:0016701|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen;GO:0050113|inositol oxygenase activity;GO:0050661|NADP binding;","K00469","MIOX; inositol oxygenase [EC:1.13.99.1]"]
["ENSRNOG00000012054",2855,183.663401,1151,74.31070046,2.471560621,1.305422293,{"v":2.0025e-163,"d":"2.00E-163"},{"v":1.9451E-162,"d":"1.95E-162"},"up","yes","Zmpste24","protein_coding","chr5:134627229-134660110:-","gi|157818557|ref|NP_001101444.1|",2216,0,"CAAX prenyl protease 1 homolog [Rattus norvegicus]","gi|157818556|ref|NM_001107974.1|",1893,0,"Rattus norvegicus zinc metallopeptidase STE24 (Zmpste24), mRNA","Q80W54",842,0,"CAAX prenyl protease 1 homolog","SPAC3H1.05",238,{"v":1e-67,"d":"1.00E-67"},"COG0501","pfam01435","Peptidase_M48","Peptidase family M48.","GO:0001889|liver development;GO:0001942|hair follicle development;GO:0003007|heart morphogenesis;GO:0003229|ventricular cardiac muscle tissue development;GO:0003231|cardiac ventricle development;GO:0003417|growth plate cartilage development;GO:0006281|DNA repair;GO:0006325|chromatin organization;GO:0006355|regulation of transcription, DNA-templated;GO:0006925|inflammatory cell apoptotic process;GO:0006974|cellular response to DNA damage stimulus;GO:0006997|nucleus organization;GO:0006998|nuclear envelope organization;GO:0007346|regulation of mitotic cell cycle;GO:0007628|adult walking behavior;GO:0008016|regulation of heart contraction;GO:0008150|biological_process;GO:0008340|determination of adult lifespan;GO:0008360|regulation of cell shape;GO:0008544|epidermis development;GO:0010506|regulation of autophagy;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010906|regulation of glucose metabolic process;GO:0016485|protein processing;GO:0019216|regulation of lipid metabolic process;GO:0030282|bone mineralization;GO:0030327|prenylated protein catabolic process;GO:0030500|regulation of bone mineralization;GO:0032006|regulation of TOR signaling;GO:0032350|regulation of hormone metabolic process;GO:0035264|multicellular organism growth;GO:0040014|regulation of multicellular organism growth;GO:0043007|maintenance of rDNA;GO:0043516|regulation of DNA damage response, signal transduction by p53 class mediator;GO:0043969|histone H2B acetylation;GO:0043979|histone H2B-K5 acetylation;GO:0044029|hypomethylation of CpG island;GO:0044030|regulation of DNA methylation;GO:0044255|cellular lipid metabolic process;GO:0048145|regulation of fibroblast proliferation;GO:0048538|thymus development;GO:0050688|regulation of defense response to virus;GO:0050905|neuromuscular process;GO:0051276|chromosome organization;GO:0055013|cardiac muscle cell development;GO:0060307|regulation of ventricular cardiac muscle cell membrane repolarization;GO:0060993|kidney morphogenesis;GO:0061337|cardiac conduction;GO:0061762|CAMKK-AMPK signaling cascade;GO:0070302|regulation of stress-activated protein kinase signaling cascade;GO:0071480|cellular response to gamma radiation;GO:0071586|CAAX-box protein processing;GO:0072423|response to DNA damage checkpoint signaling;GO:0090239|regulation of histone H4 acetylation;GO:1903025|regulation of RNA polymerase II regulatory region sequence-specific DNA binding;GO:1903463|regulation of mitotic cell cycle DNA replication;GO:1903522|regulation of blood circulation;GO:1903799|negative regulation of production of miRNAs involved in gene silencing by miRNA;GO:1990036|calcium ion import into sarcoplasmic reticulum;GO:1990164|histone H2A phosphorylation;GO:2000618|regulation of histone H4-K16 acetylation;GO:2000730|regulation of termination of RNA polymerase I transcription;GO:2000772|regulation of cellular senescence;","GO:0005575|cellular_component;GO:0005635|nuclear envelope;GO:0016020|membrane;GO:0030176|integral component of endoplasmic reticulum membrane;GO:0032991|protein-containing complex;","GO:0003674|molecular_function;GO:0003690|double-stranded DNA binding;GO:0004175|endopeptidase activity;GO:0004222|metalloendopeptidase activity;GO:0046872|metal ion binding;","K06013","STE24; STE24 endopeptidase [EC:3.4.24.84]"]
["ENSRNOG00000019147",2830,182.0551401,1139,73.53595815,2.475729489,1.307853687,{"v":1.7935e-162,"d":"1.79E-162"},{"v":1.7274E-161,"d":"1.73E-161"},"up","yes","Stom","protein_coding","chr3:18644378-18667354:-","gi|58865500|ref|NP_001011965.1|",1265,{"v":4e-164,"d":"4.00E-164"},"erythrocyte band 7 integral membrane protein [Rattus norvegicus]","gi|58865499|ref|NM_001011965.1|",1668,0,"Rattus norvegicus stomatin (Stom), mRNA","P54116",478,{"v":2E-160,"d":"2.00E-160"},"Erythrocyte band 7 integral membrane protein","AF1420",212,{"v":2e-61,"d":"2.00E-61"},"COG0330","pfam01145","Band_7","SPFH domain / Band 7 family. This family has been called SPFH, Band 7 or PHB domain. Recent phylogenetic analysis has shown this domain to be a slipin or Stomatin-like integral membrane domain conserved from protozoa to mammals.","GO:0008150|biological_process;GO:0034765|regulation of ion transmembrane transport;GO:0044829|positive regulation by host of viral genome replication;GO:0048524|positive regulation of viral process;GO:0090314|positive regulation of protein targeting to membrane;GO:1901585|regulation of acid-sensing ion channel activity;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005783|endoplasmic reticulum;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0045121|membrane raft;GO:0048471|perinuclear region of cytoplasm;","GO:0005515|protein binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0070063|RNA polymerase binding;","K17286","STOM; erythrocyte band 7 integral membrane protein"]
["ENSRNOG00000019943",2944,189.38881,1214,78.37809762,2.416348645,1.27282863,{"v":4.7744e-162,"d":"4.77E-162"},{"v":4.5906e-161,"d":"4.59E-161"},"up","yes","Slc7a6","protein_coding","chr19:34074286-34100268:+","gi|564395537|ref|XP_006255560.1|",2626,0,"PREDICTED: Y+L amino acid transporter 2 isoform X2 [Rattus norvegicus]","gi|672084831|ref|XM_006255498.2|",3712,0,"PREDICTED: Rattus norvegicus solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 (Slc7a6), transcript variant X1, mRNA","Q8BGK6",976,0,"Y+L amino acid transporter 2","BS_ykbA",150,{"v":2e-37,"d":"2.00E-37"},"COG0531","pfam13520","AA_permease_2","Amino acid permease.","GO:0003333|amino acid transmembrane transport;GO:0015807|L-amino acid transport;GO:0015822|ornithine transport;GO:1902475|L-alpha-amino acid transmembrane transport;GO:1990822|basic amino acid transmembrane transport;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0015174|basic amino acid transmembrane transporter activity;GO:0015179|L-amino acid transmembrane transporter activity;","K13872","SLC7A6; solute carrier family 7 (L-type amino acid transporter), member 6"]
["ENSRNOG00000006795",2082,133.9359723,685,44.22487386,3.028521296,1.598613556,{"v":1.7966e-161,"d":"1.80E-161"},{"v":1.7217e-160,"d":"1.72E-160"},"up","yes","Apmap","protein_coding","chr3:139409022-139437341:-","gi|564343538|ref|XP_006235277.1|",2019,0,"PREDICTED: adipocyte plasma membrane-associated protein isoform X2 [Rattus norvegicus]","gi|672047580|ref|XM_008762362.1|",2023,0,"PREDICTED: Rattus norvegicus adipocyte plasma membrane associated protein (Apmap), transcript variant X2, mRNA","Q9D7N9",771,0,"Adipocyte plasma membrane-associated protein","PA1293",221,{"v":2e-63,"d":"2.00E-63"},"COG3386","pfam03088","Str_synth","Strictosidine synthase. Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid biosynthesis. It catalyses the condensation of tryptamine with secologanin to form strictosidine.","GO:0009058|biosynthetic process;","GO:0009986|cell surface;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0004064|arylesterase activity;GO:0016844|strictosidine synthase activity;","K21407","APMAP; adipocyte plasma membrane-associated protein"]
["ENSRNOG00000043377",3721,239.3735605,1735,112.0148265,2.13698104,1.095574108,{"v":2.2606E-161,"d":"2.26E-161"},{"v":2.159e-160,"d":"2.16E-160"},"up","yes","Rusc1","protein_coding","chr2:174486665-174507776:-","gi|672043205|ref|XP_008759454.1|",3663,0,"PREDICTED: RUN and SH3 domain-containing protein 1 isoform X3 [Rattus norvegicus]","gi|672043204|ref|XM_008761232.1|",3764,0,"PREDICTED: Rattus norvegicus RUN and SH3 domain containing 1-like (LOC100360417), transcript variant X5, mRNA","P14324",735,0,"Farnesyl pyrophosphate synthase","SPAC6F12.13c",330,{"v":9e-100,"d":"9.00E-100"},"COG0142","pfam00348","polyprenyl_synt","Polyprenyl synthetase.","GO:0000209|protein polyubiquitination;GO:0006695|cholesterol biosynthetic process;GO:0007283|spermatogenesis;GO:0008299|isoprenoid biosynthetic process;GO:0008584|male gonad development;GO:0009410|response to xenobiotic stimulus;GO:0033384|geranyl diphosphate biosynthetic process;GO:0033574|response to testosterone;GO:0043434|response to peptide hormone;GO:0045337|farnesyl diphosphate biosynthetic process;GO:0045542|positive regulation of cholesterol biosynthetic process;GO:0061051|positive regulation of cell growth involved in cardiac muscle cell development;GO:0070723|response to cholesterol;GO:0071398|cellular response to fatty acid;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005759|mitochondrial matrix;GO:0005777|peroxisome;GO:0005829|cytosol;","GO:0004161|dimethylallyltranstransferase activity;GO:0004337|geranyltranstransferase activity;GO:0016740|transferase activity;GO:0046872|metal ion binding;","K00787","FDPS; farnesyl diphosphate synthase [EC:2.5.1.1 2.5.1.10]"]
["ENSRNOG00000015421",1956,125.8303371,616,39.77010555,3.163942749,1.661723495,{"v":2.2172e-160,"d":"2.22E-160"},{"v":2.1e-159,"d":"2.10E-159"},"up","yes","Slc27a3","protein_coding","chr2:175853241-175857909:-","gi|157823505|ref|NP_001099909.1|",2962,0,"long-chain fatty acid transport protein 3 precursor [Rattus norvegicus]","gi|157823504|ref|NM_001106439.1|",2274,0,"Rattus norvegicus solute carrier family 27 member 3 (Slc27a3), mRNA","O88561",1068,0,"Long-chain fatty acid transport protein 3",".",".",".",".","pfam00501","AMP-binding","AMP-binding enzyme.","GO:0001676|long-chain fatty acid metabolic process;GO:0008150|biological_process;GO:0015908|fatty acid transport;GO:0015909|long-chain fatty acid transport;","GO:0005575|cellular_component;GO:0005739|mitochondrion;GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0004321|fatty-acyl-CoA synthase activity;GO:0004467|long-chain fatty acid-CoA ligase activity;GO:0005324|long-chain fatty acid transporter activity;GO:0031957|very long-chain fatty acid-CoA ligase activity;","K08772","SLC27A3, FATP3; solute carrier family 27 (fatty acid transporter), member 3 [EC:6.2.1.-]"]
["ENSRNOG00000003235",3982,256.1638049,1923,124.1524561,2.063300339,1.044953839,{"v":6.6541e-160,"d":"6.65E-160"},{"v":6.2816e-159,"d":"6.28E-159"},"up","yes","Mgat4b","protein_coding","chr10:34549433-34559229:+","gi|189011705|ref|NP_001121005.1|",2824,0,"alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B precursor [Rattus norvegicus]","gi|189011704|ref|NM_001127533.1|",2395,0,"Rattus norvegicus mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B (Mgat4b), mRNA","Q812F8",1088,0,"Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B",".",".",".",".","pfam04666","Glyco_transf_54","N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region. The complex-type of oligosaccharides are synthesized through elongation by glycosyltransferases after trimming of the precursor oligosaccharides transferred to proteins in the endoplasmic reticulum. N-Acetylglucosaminyltransferases (GnTs) take part in the formation of branches in the biosynthesis of complex-type sugar chains. In vertebrates, six GnTs, designated as GnT-I to -VI, which catalyse the transfer of GlcNAc to the core mannose residues of Asn-linked sugar chains, have been identified. GnT-IV (EC:2.4.1.145) catalyses the transfer of GlcNAc from UDP-GlcNAc to the GlcNAc1-2Man1-3 arm of core oligosaccharide [Gn2(22)core oligosaccharide] and forms GlcNAc1-4(GlcNAc1-2)Man1-3 structure on the core oligosaccharide (Gn3(2,4,2)core oligosaccharide). In some members the conserved region occupies all but the very for N-terminal, where there is a signal sequence on all members. For other members the conserved region does not occupy the entire protein but is still to the N-terminus of the protein.","GO:0006487|protein N-linked glycosylation;","GO:0005783|endoplasmic reticulum;GO:0005793|endoplasmic reticulum-Golgi intermediate compartment;GO:0005795|Golgi stack;","GO:0008375|acetylglucosaminyltransferase activity;GO:0016757|transferase activity, transferring glycosyl groups;","K00738","MGAT4A_B; alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase A/B [EC:2.4.1.145]"]
["ENSRNOG00000010034",3552,228.5017164,1634,105.4940787,2.166014617,1.115042979,{"v":1.5773e-158,"d":"1.58E-158"},{"v":1.4792e-157,"d":"1.48E-157"},"up","yes","Asah1","protein_coding","chr16:50966229-51008233:+","gi|40254747|ref|NP_445859.2|",1978,0,"acid ceramidase precursor [Rattus norvegicus]","gi|402745984|ref|NM_053407.3|",2200,0,"Rattus norvegicus N-acylsphingosine amidohydrolase (acid ceramidase) 1 (Asah1), mRNA","Q6P7S1",766,0,"Acid ceramidase",".",".",".",".","pfam02275","CBAH","Linear amide C-N hydrolases, choloylglycine hydrolase family. This family includes several hydrolases which cleave carbon-nitrogen bonds, other than peptide bonds, in linear amides. These include choloylglycine hydrolase (conjugated bile acid hydrolase, CBAH) EC:3.5.1.24, penicillin acylase EC:3.5.1.11 and acid ceramidase EC:3.5.1.23. This domain forms the alpha-subunit for members from vertebral species, see family NAAA-beta, pfam15508.","GO:0006631|fatty acid metabolic process;GO:0010033|response to organic substance;GO:0030216|keratinocyte differentiation;GO:0030324|lung development;GO:0046512|sphingosine biosynthetic process;GO:0046513|ceramide biosynthetic process;GO:0046514|ceramide catabolic process;GO:0050810|regulation of steroid biosynthetic process;GO:0071356|cellular response to tumor necrosis factor;GO:1903507|negative regulation of nucleic acid-templated transcription;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005764|lysosome;","GO:0003674|molecular_function;GO:0003714|transcription corepressor activity;GO:0016810|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;GO:0016811|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides;GO:0016922|nuclear receptor binding;GO:0017040|N-acylsphingosine amidohydrolase activity;GO:0017064|fatty acid amide hydrolase activity;GO:0102121|ceramidase activity;","K12348","ASAH1; acid ceramidase [EC:3.5.1.23]"]
["ENSRNOG00000029450",1409,90.6415874,333,21.49909927,4.216064417,2.07589691,{"v":3.0823e-156,"d":"3.08E-156"},{"v":2.8578e-155,"d":"2.86E-155"},"up","yes","Adgrb1","protein_coding","chr7:106404958-106476902:+","gi|294345428|ref|NP_001164068.2|",7384,0,"brain-specific angiogenesis inhibitor 1 precursor [Rattus norvegicus]","gi|294345427|ref|NM_001170597.2|",5511,0,"Rattus norvegicus brain-specific angiogenesis inhibitor 1 (Bai1), mRNA","C0HL12",2848,0,"Adhesion G protein-coupled receptor B1",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0006910|phagocytosis, recognition;GO:0006911|phagocytosis, engulfment;GO:0007166|cell surface receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007399|nervous system development;GO:0007517|muscle organ development;GO:0010596|negative regulation of endothelial cell migration;GO:0016525|negative regulation of angiogenesis;GO:0031397|negative regulation of protein ubiquitination;GO:0042177|negative regulation of protein catabolic process;GO:0043277|apoptotic cell clearance;GO:0043652|engulfment of apoptotic cell;GO:0045087|innate immune response;GO:0048167|regulation of synaptic plasticity;GO:0050829|defense response to Gram-negative bacterium;GO:0051963|regulation of synapse assembly;GO:0051965|positive regulation of synapse assembly;GO:0098974|postsynaptic actin cytoskeleton organization;GO:1901741|positive regulation of myoblast fusion;GO:1903428|positive regulation of reactive oxygen species biosynthetic process;","GO:0001891|phagocytic cup;GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005925|focal adhesion;GO:0014069|postsynaptic density;GO:0030425|dendrite;GO:0043197|dendritic spine;GO:0048471|perinuclear region of cytoplasm;GO:0098978|glutamatergic synapse;GO:0099055|integral component of postsynaptic membrane;","GO:0001530|lipopolysaccharide binding;GO:0001786|phosphatidylserine binding;GO:0004888|transmembrane signaling receptor activity;GO:0004930|G protein-coupled receptor activity;GO:0005515|protein binding;GO:0030165|PDZ domain binding;","K04596","ADGRB1, BAI1; adhesion G protein-coupled receptor B1"]
["ENSRNOG00000007387",3489,224.4488988,1612,104.0737178,2.156633813,1.108781234,{"v":2.3193e-154,"d":"2.32E-154"},{"v":2.1365E-153,"d":"2.14E-153"},"up","yes","Per1","protein_coding","chr10:53805535-53814431:+","gi|86477155|ref|NP_001029297.1|",4394,0,"period circadian protein homolog 1 [Rattus norvegicus]","gi|672067780|ref|XM_006246613.2|",4001,0,"PREDICTED: Rattus norvegicus period circadian clock 1 (Per1), transcript variant X2, mRNA","Q8CHI5",1697,0,"Period circadian protein homolog 1",".",".",".",".","pfam12114","Period_C","Period protein 2/3C-terminal region. This domain is found in eukaryotes. This domain is typically between 164 to 200 amino acids in length. This domain is found associated with pfam08447.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0002028|regulation of sodium ion transport;GO:0007623|circadian rhythm;GO:0009416|response to light stimulus;GO:0010608|posttranscriptional regulation of gene expression;GO:0032922|circadian regulation of gene expression;GO:0042634|regulation of hair cycle;GO:0042752|regulation of circadian rhythm;GO:0043124|negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043153|entrainment of circadian clock by photoperiod;GO:0043966|histone H3 acetylation;GO:0043967|histone H4 acetylation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046329|negative regulation of JNK cascade;GO:0051591|response to cAMP;GO:0070932|histone H3 deacetylation;GO:0097167|circadian regulation of translation;GO:1900015|regulation of cytokine production involved in inflammatory response;GO:1900744|regulation of p38MAPK cascade;GO:2000323|negative regulation of glucocorticoid receptor signaling pathway;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001222|transcription corepressor binding;GO:0005515|protein binding;GO:0019900|kinase binding;GO:0031490|chromatin DNA binding;GO:0031625|ubiquitin protein ligase binding;GO:0070888|E-box binding;","K21944","PER1; period circadian protein 1"]
["ENSRNOG00000015233",2941,189.1958187,1246,80.44407713,2.351892463,1.233822097,{"v":2.7834e-154,"d":"2.78E-154"},{"v":2.5599e-153,"d":"2.56E-153"},"up","yes","Etfa","protein_coding","chr8:55835134-55891969:-","gi|227500281|ref|NP_663590.3|",1369,0,"electron transfer flavoprotein subunit alpha, mitochondrial [Mus musculus]","gi|57527203|ref|NM_001009668.1|",1043,0,"Rattus norvegicus electron transfer flavoprotein alpha subunit (Etfa), mRNA","Q99LC5",531,0,"Electron transfer flavoprotein subunit alpha, mitochondrial","PA2951",277,{"v":2e-86,"d":"2.00E-86"},"COG2025","pfam00766","ETF_alpha","Electron transfer flavoprotein FAD-binding domain. This domain found at the C-terminus of electron transfer flavoprotein alpha chain and binds to FAD. The fold consists of a five-stranded parallel beta sheet as the core of the domain, flanked by alternating helices. A small part of this domain is donated by the beta chain.","GO:0008150|biological_process;GO:0022900|electron transport chain;GO:0033539|fatty acid beta-oxidation using acyl-CoA dehydrogenase;","GO:0005575|cellular_component;GO:0005739|mitochondrion;GO:0005759|mitochondrial matrix;","GO:0009055|electron transfer activity;GO:0016491|oxidoreductase activity;GO:0050660|flavin adenine dinucleotide binding;","K03522","fixB, etfA; electron transfer flavoprotein alpha subunit"]
["ENSRNOG00000069423",1937,124.6080588,628,40.54484786,3.073338916,1.61980687,{"v":3.271e-153,"d":"3.27E-153"},{"v":2.9891e-152,"d":"2.99E-152"},"up","yes","ENSRNOG00000069423","protein_coding","chr8:2791853-2797967:+","gi|852749799|ref|XP_012872059.1|",906,{"v":6e-110,"d":"6.00E-110"},"PREDICTED: endogenous retrovirus group K member 8 Pol protein-like [Dipodomys ordii]","gi|153791782|ref|NG_006339.2|",1765,0,"Rattus norvegicus vomeronasal 2 receptor, pseudogene 55 (Vom2r-ps55) on chromosome 1","P04026",298,{"v":3e-91,"d":"3.00E-91"},"Intracisternal A-particle Pol-related polyprotein (Fragment)",".",".",".",".","pfam00665","rve","Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyses the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.",".",".",".",".","."]
["ENSRNOG00000016414",3285,211.3254894,1480,95.55155229,2.211638475,1.145115575,{"v":4.3059e-153,"d":"4.31E-153"},{"v":3.9285e-152,"d":"3.93E-152"},"up","yes","Slc22a17","protein_coding","chr15:28382292-28388799:-","gi|803249319|ref|XP_011984643.1|",2155,0,"PREDICTED: solute carrier family 22 member 17 isoform X2 [Ovis aries musimon]","gi|564386150|ref|XM_006251965.1|",2350,0,"PREDICTED: Rattus norvegicus solute carrier family 22, member 17 (Slc22a17), transcript variant X1, mRNA","Q3SZQ2",788,0,"Solute carrier family 22 member 17",".",".",".",".","pfam07690","MFS_1","Major Facilitator Superfamily.","GO:0015891|siderophore transport;GO:0055072|iron ion homeostasis;GO:0055085|transmembrane transport;","GO:0005774|vacuolar membrane;GO:0005887|integral component of plasma membrane;GO:0031301|integral component of organelle membrane;","GO:0004888|transmembrane signaling receptor activity;GO:0022857|transmembrane transporter activity;","K08213","SLC22A17; MFS transporter, OCT family, solute carrier family 22 (organic cation transporter), member 17"]
["ENSRNOG00000021168",3478,223.741264,1613,104.1382796,2.148501635,1.103330875,{"v":1.1235E-152,"d":"1.12E-152"},{"v":1.0218E-151,"d":"1.02E-151"},"up","yes","Anp32e","protein_coding","chr2:183472609-183489054:+","gi|148706910|gb|EDL38857.1|",808,{"v":4e-96,"d":"4.00E-96"},"acidic (leucine-rich) nuclear phosphoprotein 32 family, member E, isoform CRA_b, partial [Mus musculus]","gi|254587995|ref|NM_023210.4|",2000,0,"Mus musculus acidic (leucine-rich) nuclear phosphoprotein 32 family, member E (Anp32e), transcript variant 1, mRNA","Q5XIE0",306,{"v":5e-94,"d":"5.00E-94"},"Acidic leucine-rich nuclear phosphoprotein 32 family member E",".",".",".",".","pfam12799","LRR_4","Leucine Rich repeats (2 copies). Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.","GO:0042981|regulation of apoptotic process;GO:0043086|negative regulation of catalytic activity;GO:0043486|histone exchange;","GO:0000812|Swr1 complex;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0031410|cytoplasmic vesicle;","GO:0019212|phosphatase inhibitor activity;GO:0042393|histone binding;","K18648","ANP32E; acidic leucine-rich nuclear phosphoprotein 32 family member E"]
["ENSRNOG00000007234",2472,159.0248432,960,61.97938527,2.565769933,1.359391813,{"v":9.3223e-151,"d":"9.32E-151"},{"v":8.4111e-150,"d":"8.41E-150"},"up","yes","Cyp51","protein_coding","chr4:30036865-30055410:+","gi|6978751|ref|NP_037073.1|",2475,0,"lanosterol 14-alpha demethylase [Rattus norvegicus]","gi|56799391|ref|NM_012941.2|",3013,0,"Rattus norvegicus cytochrome P450, family 51 (Cyp51), mRNA","Q64654",957,0,"Lanosterol 14-alpha demethylase","SPAC13A11.02c",312,{"v":9e-94,"d":"9.00E-94"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0006694|steroid biosynthetic process;GO:0007283|spermatogenesis;GO:0010288|response to lead ion;GO:0016125|sterol metabolic process;GO:0032868|response to insulin;GO:0033488|cholesterol biosynthetic process via 24,25-dihydrolanosterol;GO:0042177|negative regulation of protein catabolic process;GO:0044752|response to human chorionic gonadotropin;GO:0045540|regulation of cholesterol biosynthetic process;GO:0050709|negative regulation of protein secretion;GO:0060282|positive regulation of oocyte development;GO:0070988|demethylation;GO:1900222|negative regulation of amyloid-beta clearance;","GO:0001669|acrosomal vesicle;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0004497|monooxygenase activity;GO:0005506|iron ion binding;GO:0008398|sterol 14-demethylase activity;GO:0016491|oxidoreductase activity;GO:0020037|heme binding;","K05917","CYP51; sterol 14alpha-demethylase [EC:1.14.14.154 1.14.15.36]"]
["ENSRNOG00000027839",2922,187.9735404,1250,80.70232457,2.329220891,1.219847464,{"v":1.311E-150,"d":"1.31E-150"},{"v":1.181e-149,"d":"1.18E-149"},"up","yes","Ptk2b","protein_coding","chr15:40360723-40481282:-","gi|148747528|ref|NP_059014.2|",5202,0,"protein-tyrosine kinase 2-beta [Rattus norvegicus]","gi|1000679|dbj|D45854.1|",4023,0,"Rattus norvegicus mRNA for CAK beta (cell adhesion kinase beta), complete cds","P70600",2009,0,"Protein-tyrosine kinase 2-beta",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0000165|MAPK cascade;GO:0000302|response to reactive oxygen species;GO:0001525|angiogenesis;GO:0001556|oocyte maturation;GO:0001666|response to hypoxia;GO:0001954|positive regulation of cell-matrix adhesion;GO:0002040|sprouting angiogenesis;GO:0002250|adaptive immune response;GO:0002315|marginal zone B cell differentiation;GO:0006468|protein phosphorylation;GO:0006970|response to osmotic stress;GO:0007015|actin filament organization;GO:0007155|cell adhesion;GO:0007166|cell surface receptor signaling pathway;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007172|signal complex assembly;GO:0007173|epidermal growth factor receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007229|integrin-mediated signaling pathway;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0008360|regulation of cell shape;GO:0009410|response to xenobiotic stimulus;GO:0009612|response to mechanical stimulus;GO:0009725|response to hormone;GO:0009749|response to glucose;GO:0010226|response to lithium ion;GO:0010243|response to organonitrogen compound;GO:0010595|positive regulation of endothelial cell migration;GO:0010656|negative regulation of muscle cell apoptotic process;GO:0010752|regulation of cGMP-mediated signaling;GO:0010758|regulation of macrophage chemotaxis;GO:0010976|positive regulation of neuron projection development;GO:0014009|glial cell proliferation;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0030154|cell differentiation;GO:0030155|regulation of cell adhesion;GO:0030279|negative regulation of ossification;GO:0030307|positive regulation of cell growth;GO:0030335|positive regulation of cell migration;GO:0030502|negative regulation of bone mineralization;GO:0030838|positive regulation of actin filament polymerization;GO:0031175|neuron projection development;GO:0032270|positive regulation of cellular protein metabolic process;GO:0032960|regulation of inositol trisphosphate biosynthetic process;GO:0033209|tumor necrosis factor-mediated signaling pathway;GO:0035902|response to immobilization stress;GO:0038083|peptidyl-tyrosine autophosphorylation;GO:0042220|response to cocaine;GO:0042542|response to hydrogen peroxide;GO:0042976|activation of Janus kinase activity;GO:0043066|negative regulation of apoptotic process;GO:0043149|stress fiber assembly;GO:0043267|negative regulation of potassium ion transport;GO:0043507|positive regulation of JUN kinase activity;GO:0043524|negative regulation of neuron apoptotic process;GO:0043534|blood vessel endothelial cell migration;GO:0043552|positive regulation of phosphatidylinositol 3-kinase activity;GO:0045087|innate immune response;GO:0045428|regulation of nitric oxide biosynthetic process;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0045453|bone resorption;GO:0045471|response to ethanol;GO:0045638|negative regulation of myeloid cell differentiation;GO:0045727|positive regulation of translation;GO:0045766|positive regulation of angiogenesis;GO:0045860|positive regulation of protein kinase activity;GO:0046330|positive regulation of JNK cascade;GO:0048010|vascular endothelial growth factor receptor signaling pathway;GO:0048041|focal adhesion assembly;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050848|regulation of calcium-mediated signaling;GO:0051000|positive regulation of nitric-oxide synthase activity;GO:0051279|regulation of release of sequestered calcium ion into cytosol;GO:0051591|response to cAMP;GO:0051592|response to calcium ion;GO:0051968|positive regulation of synaptic transmission, glutamatergic;GO:0060291|long-term synaptic potentiation;GO:0060292|long-term synaptic depression;GO:0070098|chemokine-mediated signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071300|cellular response to retinoic acid;GO:0071498|cellular response to fluid shear stress;GO:0086100|endothelin receptor signaling pathway;GO:0090630|activation of GTPase activity;GO:2000058|regulation of ubiquitin-dependent protein catabolic process;GO:2000060|positive regulation of ubiquitin-dependent protein catabolic process;GO:2000114|regulation of establishment of cell polarity;GO:2000249|regulation of actin cytoskeleton reorganization;GO:2000310|regulation of NMDA receptor activity;GO:2000379|positive regulation of reactive oxygen species metabolic process;GO:2000463|positive regulation of excitatory postsynaptic potential;GO:2000538|positive regulation of B cell chemotaxis;GO:2000573|positive regulation of DNA biosynthetic process;","GO:0005634|nucleus;GO:0005856|cytoskeleton;GO:0005925|focal adhesion;GO:0005938|cell cortex;GO:0014069|postsynaptic density;GO:0017146|NMDA selective glutamate receptor complex;GO:0030027|lamellipodium;GO:0030424|axon;GO:0030425|dendrite;GO:0030426|growth cone;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0042995|cell projection;GO:0043025|neuronal cell body;GO:0043197|dendritic spine;GO:0044297|cell body;GO:0045121|membrane raft;GO:0048471|perinuclear region of cytoplasm;GO:0097440|apical dendrite;GO:0098794|postsynapse;GO:0098978|glutamatergic synapse;","GO:0004672|protein kinase activity;GO:0004683|calmodulin-dependent protein kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0005102|signaling receptor binding;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0008022|protein C-terminus binding;GO:0019899|enzyme binding;GO:0031625|ubiquitin protein ligase binding;GO:0043423|3-phosphoinositide-dependent protein kinase binding;GO:0044877|protein-containing complex binding;","K05871","PTK2B, FAK2; focal adhesion kinase 2 [EC:2.7.10.2]"]
["ENSRNOG00000018059",1580,101.6420923,438,28.27809453,3.594375577,1.845741164,{"v":4.3637e-150,"d":"4.36E-150"},{"v":3.9186e-149,"d":"3.92E-149"},"up","yes","Ihh","protein_coding","chr9:76504315-76510532:-","gi|1890097|gb|AAB49692.1|",2045,0,"Indian hedgehog protein [Mus musculus]","gi|213688397|ref|NM_053384.1|",2272,0,"Rattus norvegicus Indian hedgehog (Ihh), mRNA","P97812",726,0,"Indian hedgehog protein",".",".",".",".","pfam01085","HH_signal","Hedgehog amino-terminal signalling domain. For the carboxyl Hint module, see pfam01079. Hedgehog is a family of secreted signal molecules required for embryonic cell differentiation.","GO:0001501|skeletal system development;GO:0001503|ossification;GO:0001569|branching involved in blood vessel morphogenesis;GO:0001649|osteoblast differentiation;GO:0001701|in utero embryonic development;GO:0001708|cell fate specification;GO:0001763|morphogenesis of a branching structure;GO:0001944|vasculature development;GO:0001947|heart looping;GO:0002053|positive regulation of mesenchymal cell proliferation;GO:0003382|epithelial cell morphogenesis;GO:0003406|retinal pigment epithelium development;GO:0003413|chondrocyte differentiation involved in endochondral bone morphogenesis;GO:0006029|proteoglycan metabolic process;GO:0007224|smoothened signaling pathway;GO:0007267|cell-cell signaling;GO:0007389|pattern specification process;GO:0008284|positive regulation of cell proliferation;GO:0009612|response to mechanical stimulus;GO:0009880|embryonic pattern specification;GO:0010468|regulation of gene expression;GO:0016539|intein-mediated protein splicing;GO:0016540|protein autoprocessing;GO:0030154|cell differentiation;GO:0030704|vitelline membrane formation;GO:0031016|pancreas development;GO:0032355|response to estradiol;GO:0032967|positive regulation of collagen biosynthetic process;GO:0033085|negative regulation of T cell differentiation in thymus;GO:0033088|negative regulation of immature T cell proliferation in thymus;GO:0033089|positive regulation of T cell differentiation in thymus;GO:0035264|multicellular organism growth;GO:0035988|chondrocyte proliferation;GO:0040008|regulation of growth;GO:0042733|embryonic digit morphogenesis;GO:0043010|camera-type eye development;GO:0043066|negative regulation of apoptotic process;GO:0045453|bone resorption;GO:0045596|negative regulation of cell differentiation;GO:0045880|positive regulation of smoothened signaling pathway;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046638|positive regulation of alpha-beta T cell differentiation;GO:0046639|negative regulation of alpha-beta T cell differentiation;GO:0048074|negative regulation of eye pigmentation;GO:0048469|cell maturation;GO:0048557|embryonic digestive tract morphogenesis;GO:0048596|embryonic camera-type eye morphogenesis;GO:0048666|neuron development;GO:0048745|smooth muscle tissue development;GO:0050679|positive regulation of epithelial cell proliferation;GO:0051216|cartilage development;GO:0060135|maternal process involved in female pregnancy;GO:0060220|camera-type eye photoreceptor cell fate commitment;GO:0060323|head morphogenesis;GO:0061053|somite development;GO:0072498|embryonic skeletal joint development;GO:0090136|epithelial cell-cell adhesion;GO:0097421|liver regeneration;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0031012|extracellular matrix;","GO:0003674|molecular_function;GO:0005113|patched binding;GO:0005509|calcium ion binding;GO:0008233|peptidase activity;","K11989","IHH; indian hedgehog"]
["ENSRNOG00000005587",3620,232.8761862,1726,111.4337698,2.089816998,1.063376613,{"v":1.0432e-149,"d":"1.04E-149"},{"v":9.3236e-149,"d":"9.32E-149"},"up","yes","Suclg1","protein_coding","chr4:105308039-105337600:+","gi|204356|gb|AAA41233.1|",1299,{"v":2E-174,"d":"2.00E-174"},"succinyl-CoA synthetase alpha subunit (EC 6.2.1.4) [Rattus norvegicus]","gi|298883291|emb|FQ217244.1|",1134,0,"Rattus norvegicus TL0ACA31YG08 mRNA sequence","P13086",504,{"v":8E-176,"d":"8.00E-176"},"Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial","RC0598",322,{"v":9e-106,"d":"9.00E-106"},"COG0074","pfam00549","Ligase_CoA","CoA-ligase. This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, malate CoA ligase and ATP-citrate lyase. Some members of the family utilize ATP others use GTP.","GO:0006099|tricarboxylic acid cycle;GO:0006104|succinyl-CoA metabolic process;GO:0006105|succinate metabolic process;","GO:0005739|mitochondrion;GO:0009361|succinate-CoA ligase complex (ADP-forming);GO:0032991|protein-containing complex;GO:0045244|succinate-CoA ligase complex (GDP-forming);","GO:0000166|nucleotide binding;GO:0004775|succinate-CoA ligase (ADP-forming) activity;GO:0004776|succinate-CoA ligase (GDP-forming) activity;GO:0019003|GDP binding;GO:0044877|protein-containing complex binding;","K01899","LSC1; succinyl-CoA synthetase alpha subunit [EC:6.2.1.4 6.2.1.5]"]
["ENSRNOG00000005660",937,60.27762058,130,8.393041755,7.181856392,2.844356805,{"v":1.542e-149,"d":"1.54E-149"},{"v":1.3761e-148,"d":"1.38E-148"},"up","yes","Fam110c","protein_coding","chr6:47638276-47644634:+","gi|68163531|ref|NP_001020222.1|",1318,{"v":1E-169,"d":"1.00E-169"},"protein FAM110C [Rattus norvegicus]","gi|68163530|ref|NM_001025051.1|",3024,0,"Rattus norvegicus family with sequence similarity 110, member C (Fam110c), mRNA","Q5RKJ0",512,{"v":4e-171,"d":"4.00E-171"},"Protein FAM110C",".",".",".",".","pfam14160","FAM110_C","Centrosome-associated C terminus. This is the C-terminus of a family of proteins that colocalize with the centrosome/microtubule organisation centre in interphase and at the spindle poles in mitosis.","GO:0030335|positive regulation of cell migration;GO:0051897|positive regulation of protein kinase B signaling;GO:0060491|regulation of cell projection assembly;","GO:0000922|spindle pole;GO:0005634|nucleus;GO:0005815|microtubule organizing center;GO:0005874|microtubule;GO:0005938|cell cortex;","GO:0043014|alpha-tubulin binding;",".","."]
["ENSRNOG00000047314",1402,90.19127434,350,22.59665088,3.991355835,1.996878903,{"v":5.9155E-148,"d":"5.92E-148"},{"v":5.2461e-147,"d":"5.25E-147"},"up","yes","Tk1","protein_coding","chr10:103031521-103046920:-","gi|158186787|ref|NP_434687.1|",1171,{"v":7e-153,"d":"7.00E-153"},"thymidine kinase, cytosolic [Rattus norvegicus]","gi|158186786|ref|NM_052800.1|",2207,0,"Rattus norvegicus thymidine kinase 1, soluble (Tk1), mRNA","P04184",406,{"v":4e-135,"d":"4.00E-135"},"Thymidine kinase, cytosolic","MYPU_1450",94.4,{"v":9e-21,"d":"9.00E-21"},"COG1435","pfam00265","TK","Thymidine kinase.","GO:0001889|liver development;GO:0009157|deoxyribonucleoside monophosphate biosynthetic process;GO:0009636|response to toxic substance;GO:0014856|skeletal muscle cell proliferation;GO:0016310|phosphorylation;GO:0031667|response to nutrient levels;GO:0046104|thymidine metabolic process;GO:0046688|response to copper ion;GO:0048565|digestive tract development;GO:0051289|protein homotetramerization;GO:0051414|response to cortisol;GO:0060138|fetal process involved in parturition;GO:0071897|DNA biosynthetic process;","GO:0005737|cytoplasm;","GO:0003674|molecular_function;GO:0004797|thymidine kinase activity;GO:0005524|ATP binding;GO:0008270|zinc ion binding;GO:0042802|identical protein binding;","K00857","tdk, TK; thymidine kinase [EC:2.7.1.21]"]
["ENSRNOG00000046204",2023,130.1404764,696,44.93505432,2.896190478,1.534156489,{"v":6.1774e-148,"d":"6.18E-148"},{"v":5.4699E-147,"d":"5.47E-147"},"up","yes","Tspan15","protein_coding","chr20:30130530-30174930:-","gi|74182476|dbj|BAE42863.1|",1506,0,"unnamed protein product [Mus musculus]","gi|169234817|ref|NM_001115032.1|",1608,0,"Rattus norvegicus tetraspanin 15 (Tspan15), mRNA","F7BWT7",546,0,"Tetraspanin-15",".",".",".",".","pfam00335","Tetraspannin","Tetraspanin family.","GO:0045746|negative regulation of Notch signaling pathway;GO:0051604|protein maturation;GO:0072659|protein localization to plasma membrane;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0016604|nuclear body;GO:0030054|cell junction;GO:0043231|intracellular membrane-bounded organelle;GO:0097197|tetraspanin-enriched microdomain;","GO:0019899|enzyme binding;","K17297","TSPAN15; tetraspanin-15"]
["ENSRNOG00000011135",1944,125.0583718,650,41.96520878,2.980048842,1.575335976,{"v":9.0398e-148,"d":"9.04E-148"},{"v":7.9798e-147,"d":"7.98E-147"},"up","yes","Gtf2b","protein_coding","chr2:231767238-231785651:+","gi|635106759|ref|XP_007976241.1|",1378,{"v":2E-179,"d":"2.00E-179"},"PREDICTED: transcription initiation factor IIB [Chlorocebus sabaeus]","gi|298898349|emb|FQ231337.1|",851,0,"Rattus norvegicus TL0AEA6YN24 mRNA sequence","P62916",530,{"v":5e-180,"d":"5.00E-180"},"Transcription initiation factor IIB","SPAC16E8.16",206,{"v":5e-58,"d":"5.00E-58"},"COG1405","pfam00382","TFIIB","Transcription factor TFIIB repeat.","GO:0001174|transcriptional start site selection at RNA polymerase II promoter;GO:0006352|DNA-templated transcription, initiation;GO:0006366|transcription by RNA polymerase II;GO:0006367|transcription initiation from RNA polymerase II promoter;GO:0006473|protein acetylation;GO:0016573|histone acetylation;GO:0019083|viral transcription;GO:0051123|RNA polymerase II preinitiation complex assembly;GO:0070897|transcription preinitiation complex assembly;GO:1904798|positive regulation of core promoter binding;GO:1990114|RNA polymerase II core complex assembly;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005669|transcription factor TFIID complex;GO:0005694|chromosome;GO:0016604|nuclear body;GO:0032993|protein-DNA complex;GO:0090575|RNA polymerase II transcription factor complex;GO:0097550|transcriptional preinitiation complex;","GO:0000979|RNA polymerase II core promoter sequence-specific DNA binding;GO:0000993|RNA polymerase II complex binding;GO:0003677|DNA binding;GO:0004402|histone acetyltransferase activity;GO:0008270|zinc ion binding;GO:0016251|RNA polymerase II general transcription initiation factor activity;GO:0016407|acetyltransferase activity;GO:0017025|TBP-class protein binding;GO:0046966|thyroid hormone receptor binding;GO:1990841|promoter-specific chromatin binding;","K03124","TFIIB, GTF2B, SUA7, tfb; transcription initiation factor TFIIB"]
["ENSRNOG00000067040",1424,91.60654398,363,23.43595505,3.908803535,1.966727074,{"v":2.5935E-147,"d":"2.59E-147"},{"v":2.2753e-146,"d":"2.28E-146"},"up","yes","ENSRNOG00000067040","protein_coding","chr3:138654777-138675861:-","gi|889029083|ref|NP_001297574.1|",1844,0,"zinc finger protein 442 [Mus musculus]","gi|23274125|gb|BC023805.1|",841,0,"Mus musculus zinc finger protein 442, mRNA (cDNA clone MGC:38507 IMAGE:5352880), complete cds","Q8BZW4",540,{"v":1E-175,"d":"1.00E-175"},"Zinc finger protein 120",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000015375",1616,103.9579881,466,30.0858266,3.455380817,1.788844719,{"v":4.2231E-147,"d":"4.22E-147"},{"v":3.6936E-146,"d":"3.69E-146"},"up","yes","Lsm1","protein_coding","chr16:66277345-66288852:-","gi|533169886|ref|XP_005398490.1|",590,{"v":3e-71,"d":"3.00E-71"},"PREDICTED: U6 snRNA-associated Sm-like protein LSm1 isoform X1 [Chinchilla lanigera]","gi|157820262|ref|NM_001108876.1|",817,0,"Rattus norvegicus LSM1 homolog, mRNA degradation associated (Lsm1), mRNA","O15116",228,{"v":2e-71,"d":"2.00E-71"},"U6 snRNA-associated Sm-like protein LSm1",".",".",".",".","pfam01423","LSM","LSM domain. The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.","GO:0000290|deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0006397|mRNA processing;GO:0008150|biological_process;GO:0016070|RNA metabolic process;GO:0019827|stem cell population maintenance;GO:0045665|negative regulation of neuron differentiation;GO:0071044|histone mRNA catabolic process;","GO:0000932|P-body;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0030424|axon;GO:0030425|dendrite;GO:0043025|neuronal cell body;GO:1990124|messenger ribonucleoprotein complex;GO:1990726|Lsm1-7-Pat1 complex;","GO:0000339|RNA cap binding;GO:0003723|RNA binding;GO:0003729|mRNA binding;GO:0036002|pre-mRNA binding;","K12620","LSM1; U6 snRNA-associated Sm-like protein LSm1"]
["ENSRNOG00000046799",3540,227.7297512,1685,108.7867335,2.093359584,1.06582015,{"v":5.5077e-147,"d":"5.51E-147"},{"v":4.8098e-146,"d":"4.81E-146"},"up","yes","Phb","protein_coding","chr10:80605251-80618042:+","gi|6679299|ref|NP_032857.1|",1283,{"v":2E-171,"d":"2.00E-171"},"prohibitin [Mus musculus]","gi|93004107|ref|NM_031851.2|",1739,0,"Rattus norvegicus prohibitin (Phb), mRNA","P67779",498,{"v":6e-173,"d":"6.00E-173"},"Prohibitin","YGR132c",283,{"v":1E-89,"d":"1.00E-89"},"COG0330","pfam01145","Band_7","SPFH domain / Band 7 family. This family has been called SPFH, Band 7 or PHB domain. Recent phylogenetic analysis has shown this domain to be a slipin or Stomatin-like integral membrane domain conserved from protozoa to mammals.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001541|ovarian follicle development;GO:0001552|ovarian follicle atresia;GO:0002639|positive regulation of immunoglobulin production;GO:0006355|regulation of transcription, DNA-templated;GO:0007005|mitochondrion organization;GO:0007202|activation of phospholipase C activity;GO:0008285|negative regulation of cell proliferation;GO:0009410|response to xenobiotic stimulus;GO:0010628|positive regulation of gene expression;GO:0010942|positive regulation of cell death;GO:0010944|negative regulation of transcription by competitive promoter binding;GO:0016575|histone deacetylation;GO:0023035|CD40 signaling pathway;GO:0030308|negative regulation of cell growth;GO:0031100|animal organ regeneration;GO:0032740|positive regulation of interleukin-17 production;GO:0034097|response to cytokine;GO:0035902|response to immobilization stress;GO:0039529|RIG-I signaling pathway;GO:0042113|B cell activation;GO:0042177|negative regulation of protein catabolic process;GO:0043066|negative regulation of apoptotic process;GO:0043434|response to peptide hormone;GO:0044830|modulation by host of viral RNA genome replication;GO:0045471|response to ethanol;GO:0045745|positive regulation of G protein-coupled receptor signaling pathway;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045917|positive regulation of complement activation;GO:0046718|viral entry into host cell;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0050821|protein stabilization;GO:0050847|progesterone receptor signaling pathway;GO:0051897|positive regulation of protein kinase B signaling;GO:0060766|negative regulation of androgen receptor signaling pathway;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071354|cellular response to interleukin-6;GO:0071897|DNA biosynthetic process;GO:0072538|T-helper 17 type immune response;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1990051|activation of protein kinase C activity;GO:2000323|negative regulation of glucocorticoid receptor signaling pathway;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0005769|early endosome;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0014069|postsynaptic density;GO:0030061|mitochondrial crista;GO:0031315|extrinsic component of mitochondrial outer membrane;GO:0035632|mitochondrial prohibitin complex;GO:0098891|extrinsic component of presynaptic active zone membrane;GO:0098978|glutamatergic synapse;GO:0098982|GABA-ergic synapse;","GO:0001850|complement component C3a binding;GO:0001851|complement component C3b binding;GO:0003674|molecular_function;GO:0003714|transcription corepressor activity;GO:0008022|protein C-terminus binding;GO:0019899|enzyme binding;GO:0031871|proteinase activated receptor binding;GO:0042826|histone deacetylase binding;GO:0046982|protein heterodimerization activity;","K17080","PHB1; prohibitin 1"]
["ENSRNOG00000026171",2134,137.2811551,768,49.58350822,2.7686858,1.469201341,{"v":2.127e-146,"d":"2.13E-146"},{"v":1.849e-145,"d":"1.85E-145"},"up","yes","Bbs4","protein_coding","chr8:59731912-59765607:-","gi|672061891|ref|XP_008764446.1|",2439,0,"PREDICTED: Bardet-Biedl syndrome 4 protein isoform X1 [Rattus norvegicus]","gi|672061890|ref|XM_008766224.1|",2639,0,"PREDICTED: Rattus norvegicus Bardet-Biedl syndrome 4 (Bbs4), transcript variant X1, mRNA","Q8C1Z7",884,0,"Bardet-Biedl syndrome 4 protein homolog","MA1362",89.4,{"v":7e-18,"d":"7.00E-18"},"COG0457","pfam13414","TPR_11","TPR repeat.","GO:0000226|microtubule cytoskeleton organization;GO:0000281|mitotic cytokinesis;GO:0001764|neuron migration;GO:0001843|neural tube closure;GO:0001895|retina homeostasis;GO:0003085|negative regulation of systemic arterial blood pressure;GO:0007098|centrosome cycle;GO:0007286|spermatid development;GO:0007608|sensory perception of smell;GO:0008104|protein localization;GO:0008150|biological_process;GO:0010629|negative regulation of gene expression;GO:0016358|dendrite development;GO:0019216|regulation of lipid metabolic process;GO:0021591|ventricular system development;GO:0021756|striatum development;GO:0021766|hippocampus development;GO:0021987|cerebral cortex development;GO:0030534|adult behavior;GO:0030837|negative regulation of actin filament polymerization;GO:0032465|regulation of cytokinesis;GO:0033210|leptin-mediated signaling pathway;GO:0033365|protein localization to organelle;GO:0034260|negative regulation of GTPase activity;GO:0034454|microtubule anchoring at centrosome;GO:0035176|social behavior;GO:0035845|photoreceptor cell outer segment organization;GO:0038108|negative regulation of appetite by leptin-mediated signaling pathway;GO:0040018|positive regulation of multicellular organism growth;GO:0044321|response to leptin;GO:0045444|fat cell differentiation;GO:0045494|photoreceptor cell maintenance;GO:0045724|positive regulation of cilium assembly;GO:0046548|retinal rod cell development;GO:0048854|brain morphogenesis;GO:0051457|maintenance of protein location in nucleus;GO:0051492|regulation of stress fiber assembly;GO:0060271|cilium assembly;GO:0060296|regulation of cilium beat frequency involved in ciliary motility;GO:0060324|face development;GO:0060613|fat pad development;GO:0061512|protein localization to cilium;GO:0071539|protein localization to centrosome;GO:1902855|regulation of non-motile cilium assembly;GO:1903546|protein localization to photoreceptor outer segment;GO:1905515|non-motile cilium assembly;","GO:0000242|pericentriolar material;GO:0001750|photoreceptor outer segment;GO:0001917|photoreceptor inner segment;GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005813|centrosome;GO:0005814|centriole;GO:0005829|cytosol;GO:0005929|cilium;GO:0016020|membrane;GO:0031514|motile cilium;GO:0032391|photoreceptor connecting cilium;GO:0034451|centriolar satellite;GO:0034464|BBSome;GO:0035869|ciliary transition zone;GO:0036064|ciliary basal body;GO:0060170|ciliary membrane;GO:0097730|non-motile cilium;","GO:0003674|molecular_function;GO:0030674|protein binding, bridging;GO:0034452|dynactin binding;GO:0043014|alpha-tubulin binding;GO:0048487|beta-tubulin binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;","K16531","BBS4; Bardet-Biedl syndrome 4 protein"]
["ENSRNOG00000001153",717,46.12492418,52,3.357216702,13.73903691,3.780208971,{"v":3.5727e-146,"d":"3.57E-146"},{"v":3.101e-145,"d":"3.10E-145"},"up","yes","Pla2g1b","protein_coding","chr12:41142200-41153226:-","gi|672072943|ref|XP_008767444.1|",629,{"v":2E-78,"d":"2.00E-78"},"PREDICTED: phospholipase A2 isoform X1 [Rattus norvegicus]","gi|672072942|ref|XM_008769222.1|",650,0,"PREDICTED: Rattus norvegicus phospholipase A2, group IB, pancreas (Pla2g1b), transcript variant X1, mRNA","P04055",244,{"v":6E-79,"d":"6.00E-79"},"Phospholipase A2",".",".",".",".","pfam00068","Phospholip_A2_1","Phospholipase A2. Phospholipase A2 releases fatty acids from the second carbon group of glycerol. Perhaps the best known members are secreted snake venoms, but also found in secreted pancreatic and membrane-associated forms. Structure is all-alpha, with two core disulfide-linked helices and a calcium-binding loop. This alignment represents the major family of PLA2s. A second minor family, defined by the honeybee venom PLA2 PDB:1POC and related sequences from Gila monsters (Heloderma), is not recognized. This minor family conserves the core helix pair but is substantially different elsewhere. The PROSITE pattern PA2_HIS, specific to the first core helix, recognizes both families.","GO:0002227|innate immune response in mucosa;GO:0002446|neutrophil mediated immunity;GO:0006633|fatty acid biosynthetic process;GO:0006644|phospholipid metabolic process;GO:0008284|positive regulation of cell proliferation;GO:0010524|positive regulation of calcium ion transport into cytosol;GO:0016042|lipid catabolic process;GO:0019370|leukotriene biosynthetic process;GO:0019731|antibacterial humoral response;GO:0030593|neutrophil chemotaxis;GO:0032757|positive regulation of interleukin-8 production;GO:0032869|cellular response to insulin stimulus;GO:0035556|intracellular signal transduction;GO:0043406|positive regulation of MAP kinase activity;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046324|regulation of glucose import;GO:0046470|phosphatidylcholine metabolic process;GO:0046471|phosphatidylglycerol metabolic process;GO:0048146|positive regulation of fibroblast proliferation;GO:0050482|arachidonic acid secretion;GO:0050778|positive regulation of immune response;GO:0050830|defense response to Gram-positive bacterium;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:1904635|positive regulation of glomerular visceral epithelial cell apoptotic process;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0009986|cell surface;GO:0030141|secretory granule;","GO:0004623|phospholipase A2 activity;GO:0005102|signaling receptor binding;GO:0005509|calcium ion binding;GO:0032052|bile acid binding;GO:0047498|calcium-dependent phospholipase A2 activity;","K01047","PLA2G, SPLA2; secretory phospholipase A2 [EC:3.1.1.4]"]
["ENSRNOG00000006400",2687,172.8558874,1117,72.11559723,2.396927905,1.261186516,{"v":5.3585e-146,"d":"5.36E-146"},{"v":4.644e-145,"d":"4.64E-145"},"up","yes","Tbc1d14","protein_coding","chr14:74172664-74272183:+","gi|164565389|ref|NP_001106836.1|",3687,0,"TBC1 domain family member 14 isoform 3 [Rattus norvegicus]","gi|164565388|ref|NM_001113365.1|",4902,0,"Rattus norvegicus TBC1 domain family, member 14 (Tbc1d14), transcript variant 3, mRNA","Q5CD77",1377,0,"TBC1 domain family member 14","SPAC23D3.03c",149,{"v":1e-36,"d":"1.00E-36"},"COG5210","pfam00566","RabGAP-TBC","Rab-GTPase-TBC domain. Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.","GO:0006886|intracellular protein transport;GO:0010507|negative regulation of autophagy;GO:0071955|recycling endosome to Golgi transport;GO:0090630|activation of GTPase activity;GO:2000785|regulation of autophagosome assembly;","GO:0005654|nucleoplasm;GO:0005776|autophagosome;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0043231|intracellular membrane-bounded organelle;GO:0055037|recycling endosome;","GO:0005096|GTPase activator activity;GO:0019901|protein kinase binding;","K20167","TBC1D14; TBC1 domain family member 14"]
["ENSRNOG00000002011",2655,170.7973134,1097,70.82436004,2.41156169,1.269967716,{"v":7.8402e-146,"d":"7.84E-146"},{"v":6.7845e-145,"d":"6.78E-145"},"up","yes","Gnrhr","protein_coding","chr14:21856871-21874861:+","gi|407039|gb|AAA41265.1|",1756,0,"gonadotropin-releasing hormone receptor [Rattus norvegicus]","gi|77812701|ref|NM_031038.3|",2611,0,"Rattus norvegicus gonadotropin releasing hormone receptor (Gnrhr), mRNA","P30969",622,0,"Gonadotropin-releasing hormone receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0007623|circadian rhythm;GO:0008285|negative regulation of cell proliferation;GO:0097211|cellular response to gonadotropin-releasing hormone;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004968|gonadotropin-releasing hormone receptor activity;GO:0005515|protein binding;GO:0016500|protein-hormone receptor activity;GO:0016520|growth hormone-releasing hormone receptor activity;GO:0042277|peptide binding;","K04280","GNRHR; gonadotropin-releasing hormone receptor"]
["ENSRNOG00000019180",3223,207.3370023,1478,95.42242857,2.172833006,1.1195773,{"v":5.7981e-145,"d":"5.80E-145"},{"v":4.9797e-144,"d":"4.98E-144"},"up","yes","Acsl4","protein_coding","chrX:105942799-106006427:-","gi|564400166|ref|XP_006257376.1|",3558,0,"PREDICTED: long-chain-fatty-acid--CoA ligase 4 isoform X2 [Rattus norvegicus]","gi|672088090|ref|XM_008773385.1|",3033,0,"PREDICTED: Rattus norvegicus acyl-CoA synthetase long-chain family member 4 (Acsl4), transcript variant X2, mRNA","Q9QUJ7",1367,0,"Long-chain-fatty-acid--CoA ligase 4","SPBC18H10.02",341,{"v":3e-99,"d":"3.00E-99"},"COG1022","pfam00501","AMP-binding","AMP-binding enzyme.","GO:0001676|long-chain fatty acid metabolic process;GO:0006629|lipid metabolic process;GO:0006631|fatty acid metabolic process;GO:0007584|response to nutrient;GO:0008610|lipid biosynthetic process;GO:0015908|fatty acid transport;GO:0019432|triglyceride biosynthetic process;GO:0030182|neuron differentiation;GO:0030307|positive regulation of cell growth;GO:0032024|positive regulation of insulin secretion;GO:0032307|negative regulation of prostaglandin secretion;GO:0035336|long-chain fatty-acyl-CoA metabolic process;GO:0035338|long-chain fatty-acyl-CoA biosynthetic process;GO:0060136|embryonic process involved in female pregnancy;GO:0060996|dendritic spine development;GO:0070672|response to interleukin-15;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0005777|peroxisome;GO:0005778|peroxisomal membrane;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005811|lipid droplet;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0031966|mitochondrial membrane;GO:0043025|neuronal cell body;GO:0044233|Mitochondria-associated ER Membrane;","GO:0004467|long-chain fatty acid-CoA ligase activity;GO:0005524|ATP binding;GO:0031957|very long-chain fatty acid-CoA ligase activity;GO:0047676|arachidonate-CoA ligase activity;","K01897","ACSL, fadD; long-chain acyl-CoA synthetase [EC:6.2.1.3]"]
["ENSRNOG00000019980",3437,221.103716,1630,105.2358312,2.101030737,1.071097268,{"v":6.6398e-144,"d":"6.64E-144"},{"v":5.6855E-143,"d":"5.69E-143"},"up","yes","Tomm20","protein_coding","chr19:54923402-54935198:-","gi|13324686|ref|NP_077176.1|",631,{"v":2E-73,"d":"2.00E-73"},"mitochondrial import receptor subunit TOM20 homolog [Mus musculus]","gi|298904539|emb|FQ224957.1|",1011,0,"Rattus norvegicus TL0ACA52YF02 mRNA sequence","Q62760",247,{"v":6e-75,"d":"6.00E-75"},"Mitochondrial import receptor subunit TOM20 homolog",".",".",".",".","pfam02064","MAS20","MAS20 protein import receptor.","GO:0006626|protein targeting to mitochondrion;GO:0014850|response to muscle activity;GO:0016031|tRNA import into mitochondrion;GO:0030150|protein import into mitochondrial matrix;GO:1905242|response to 3,3',5-triiodo-L-thyronine;","GO:0005739|mitochondrion;GO:0005740|mitochondrial envelope;GO:0005741|mitochondrial outer membrane;GO:0005742|mitochondrial outer membrane translocase complex;GO:0031307|integral component of mitochondrial outer membrane;GO:0044233|Mitochondria-associated ER Membrane;","GO:0008320|protein transmembrane transporter activity;GO:0015450|P-P-bond-hydrolysis-driven protein transmembrane transporter activity;GO:0030943|mitochondrion targeting sequence binding;GO:0051082|unfolded protein binding;","K17770","TOM20; mitochondrial import receptor subunit TOM20"]
["ENSRNOG00000000610",1836,118.1106845,605,39.05992509,3.023832847,1.596378392,{"v":2.395E-142,"d":"2.40E-142"},{"v":2.0234E-141,"d":"2.02E-141"},"up","yes","Cisd1","protein_coding","chr20:17255151-17284924:+","gi|562835612|ref|XP_006147117.1|",447,{"v":3e-50,"d":"3.00E-50"},"PREDICTED: CDGSH iron-sulfur domain-containing protein 1 isoform X2 [Tupaia chinensis]","gi|167908785|ref|NM_001106385.2|",621,0,"Rattus norvegicus CDGSH iron sulfur domain 1 (Cisd1), mRNA","B0K020",167,{"v":2e-48,"d":"2.00E-48"},"CDGSH iron-sulfur domain-containing protein 1",".",".",".",".","pfam09360","zf-CDGSH","Iron-binding zinc finger CDGSH type. The CDGSH-type zinc finger domain binds iron rather than zinc as a redox-active pH-labile 2Fe-2S cluster. The conserved sequence C-X-C-X2-(S/T)-X3-P-X-C-D-G-(S/A/T)-H is a defining feature of this family. The domain is oriented towards the cytoplasm and is tethered to the mitochondrial membrane by a more N-terminal domain found in higher vertebrates, MitoNEET_N, pfam10660. The domain forms a uniquely folded homo-dimer and spans the outer mitochondrial membrane, orienting the iron-binding residues towards the cytoplasm.","GO:0010506|regulation of autophagy;GO:0043457|regulation of cellular respiration;","GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0016021|integral component of membrane;GO:0032473|cytoplasmic side of mitochondrial outer membrane;","GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0051537|2 iron, 2 sulfur cluster binding;","K23885","CISD1; CDGSH iron-sulfur domain-containing protein 1"]
["ENSRNOG00000006364",3510,225.799838,1689,109.044981,2.070703631,1.050121083,{"v":2.5798e-142,"d":"2.58E-142"},{"v":2.1763E-141,"d":"2.18E-141"},"up","yes","Dld","protein_coding","chr6:47903914-47924795:-","gi|40786469|ref|NP_955417.1|",2675,0,"dihydrolipoyl dehydrogenase, mitochondrial precursor [Rattus norvegicus]","gi|575771755|ref|NM_199385.2|",2576,0,"Rattus norvegicus dihydrolipoamide dehydrogenase (Dld), mRNA","Q6P6R2",1035,0,"Dihydrolipoyl dehydrogenase, mitochondrial","SPAC1002.09c",550,0,"COG1249","pfam07992","Pyr_redox_2","Pyridine nucleotide-disulphide oxidoreductase. This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.","GO:0006086|acetyl-CoA biosynthetic process from pyruvate;GO:0006103|2-oxoglutarate metabolic process;GO:0006120|mitochondrial electron transport, NADH to ubiquinone;GO:0006508|proteolysis;GO:0007369|gastrulation;GO:0007568|aging;GO:0009106|lipoate metabolic process;GO:0042391|regulation of membrane potential;GO:0045454|cell redox homeostasis;GO:0048240|sperm capacitation;GO:0051068|dihydrolipoamide metabolic process;GO:0106077|histone succinylation;","GO:0005634|nucleus;GO:0005739|mitochondrion;GO:0005759|mitochondrial matrix;GO:0005929|cilium;GO:0031514|motile cilium;GO:0043159|acrosomal matrix;GO:0045252|oxoglutarate dehydrogenase complex;GO:0045254|pyruvate dehydrogenase complex;","GO:0004148|dihydrolipoyl dehydrogenase activity;GO:0034604|pyruvate dehydrogenase (NAD+) activity;GO:0043544|lipoamide binding;GO:0050660|flavin adenine dinucleotide binding;GO:0051287|NAD binding;","K00382","DLD, lpd, pdhD; dihydrolipoamide dehydrogenase [EC:1.8.1.4]"]
["ENSRNOG00000030232",2847,183.1487575,1242,80.18582969,2.284053906,1.1915967,{"v":1.5874E-141,"d":"1.59E-141"},{"v":1.3255E-140,"d":"1.33E-140"},"up","yes","Hacd3","protein_coding","chr8:65501240-65538507:-","gi|157819829|ref|NP_001100301.1|",1739,0,"very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 [Rattus norvegicus]","gi|157819828|ref|NM_001106831.1|",2913,0,"Rattus norvegicus 3-hydroxyacyl-CoA dehydratase 3 (Hacd3), mRNA","Q8K2C9",665,0,"Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3","SPBC19C2.15c",61.2,2e-09,"COG5198","pfam04387","PTPLA","Protein tyrosine phosphatase-like protein, PTPLA. This family includes the mammalian protein tyrosine phosphatase-like protein, PTPLA. A significant variation of PTPLA from other protein tyrosine phosphatases is the presence of proline instead of catalytic arginine at the active site. It is thought that PTPLA proteins have a role in the development, differentiation, and maintenance of a number of tissue types.","GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0007254|JNK cascade;GO:0007266|Rho protein signal transduction;GO:0030148|sphingolipid biosynthetic process;GO:0030497|fatty acid elongation;GO:0042761|very long-chain fatty acid biosynthetic process;GO:0045070|positive regulation of viral genome replication;GO:0046726|positive regulation by virus of viral protein levels in host cell;","GO:0005783|endoplasmic reticulum;GO:0030176|integral component of endoplasmic reticulum membrane;GO:0031965|nuclear membrane;","GO:0018812|3-hydroxyacyl-CoA dehydratase activity;GO:0019899|enzyme binding;GO:0102158|very-long-chain 3-hydroxyacyl-CoA dehydratase activity;GO:0102343|3-hydroxy-arachidoyl-CoA dehydratase activity;GO:0102344|3-hydroxy-behenoyl-CoA dehydratase activity;GO:0102345|3-hydroxy-lignoceroyl-CoA dehydratase activity;","K10703","HACD, PHS1, PAS2; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase [EC:4.2.1.134]"]
["ENSRNOG00000007907",2675,172.0839221,1129,72.89033955,2.360860482,1.239312786,{"v":1.7689e-141,"d":"1.77E-141"},{"v":1.4727E-140,"d":"1.47E-140"},"up","yes","Tmem178a","protein_coding","chr6:14004630-14063549:-","gi|51948534|ref|NP_001004282.1|",1323,{"v":2e-177,"d":"2.00E-177"},"transmembrane protein 178A precursor [Rattus norvegicus]","gi|51260761|gb|BC079338.1|",1671,0,"Rattus norvegicus transmembrane protein 178, mRNA (cDNA clone MGC:94782 IMAGE:7106500), complete cds","Q68FV0",514,{"v":5e-179,"d":"5.00E-179"},"Transmembrane protein 178A",".",".",".",".","pfam13903","Claudin_2","PMP-22/EMP/MP20/Claudin tight junction. Members of this family are claudins, that form tight junctions between cells.","GO:0045671|negative regulation of osteoclast differentiation;GO:0051480|regulation of cytosolic calcium ion concentration;","GO:0005789|endoplasmic reticulum membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000010882",2619,168.4814176,1093,70.5661126,2.387568358,1.255542039,{"v":2.2604E-141,"d":"2.26E-141"},{"v":1.8791E-140,"d":"1.88E-140"},"up","yes","Sptlc1","protein_coding","chr17:11877249-11916295:+","gi|157822249|ref|NP_001101876.1|",2186,0,"serine palmitoyltransferase 1 [Rattus norvegicus]","gi|157822248|ref|NM_001108406.1|",2968,0,"Rattus norvegicus serine palmitoyltransferase, long chain base subunit 1 (Sptlc1), mRNA","O35704",811,0,"Serine palmitoyltransferase 1","SPBC18E5.02c",311,{"v":6e-93,"d":"6.00E-93"},"COG0156","pfam00155","Aminotran_1_2","Aminotransferase class I and II.","GO:0006665|sphingolipid metabolic process;GO:0006686|sphingomyelin biosynthetic process;GO:0030148|sphingolipid biosynthetic process;GO:0046511|sphinganine biosynthetic process;GO:0046512|sphingosine biosynthetic process;GO:0046513|ceramide biosynthetic process;GO:1904504|positive regulation of lipophagy;GO:1904649|regulation of fat cell apoptotic process;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0017059|serine C-palmitoyltransferase complex;GO:0035339|SPOTS complex;","GO:0004758|serine C-palmitoyltransferase activity;GO:0030170|pyridoxal phosphate binding;","K00654","SPT; serine palmitoyltransferase [EC:2.3.1.50]"]
["ENSRNOG00000036684",2559,164.6215913,1058,68.30644752,2.410044693,1.269059901,{"v":1.7766e-140,"d":"1.78E-140"},{"v":1.4684E-139,"d":"1.47E-139"},"up","yes","Pcyt2","protein_coding","chr10:105888775-105896172:-","gi|564375726|ref|XP_006247998.1|",2082,0,"PREDICTED: ethanolamine-phosphate cytidylyltransferase isoform X2 [Rattus norvegicus]","gi|672070235|ref|XM_006247936.2|",2167,0,"PREDICTED: Rattus norvegicus phosphate cytidylyltransferase 2, ethanolamine (Pcyt2), transcript variant X2, mRNA","O88637",781,0,"Ethanolamine-phosphate cytidylyltransferase","ECU11g0870",195,{"v":6e-55,"d":"6.00E-55"},"COG0615","pfam01467","CTP_transf_2","Cytidylyltransferase. This family includes: Cholinephosphate cytidylyltransferase and Glycerol-3-phosphate cytidylyltransferase.","GO:0006646|phosphatidylethanolamine biosynthetic process;",".","GO:0004306|ethanolamine-phosphate cytidylyltransferase activity;","K00967","PCYT2; ethanolamine-phosphate cytidylyltransferase [EC:2.7.7.14]"]
["ENSRNOG00000004009",611,39.30589773,23,1.484922772,26.46999458,4.726285994,{"v":2.3146e-140,"d":"2.31E-140"},{"v":1.9103e-139,"d":"1.91E-139"},"up","yes","ENSRNOG00000004009","protein_coding","chrX:127287979-127317223:+","gi|16924020|ref|NP_476496.1|",3562,0,"xaa-Pro aminopeptidase 2 precursor [Rattus norvegicus]","gi|49258141|gb|BC074017.1|",3276,0,"Rattus norvegicus X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound, mRNA (cDNA clone MGC:91533 IMAGE:7098467), complete cds","Q99MA2",1376,0,"Xaa-Pro aminopeptidase 2","VC0067",352,{"v":9e-107,"d":"9.00E-107"},"COG0006","pfam00557","Peptidase_M24","Metallopeptidase family M24. This family contains metallopeptidases. It also contains non-peptidase homologues such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.","GO:0006508|proteolysis;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0031225|anchored component of membrane;GO:0070062|extracellular exosome;","GO:0003674|molecular_function;GO:0046872|metal ion binding;GO:0070006|metalloaminopeptidase activity;","K14208","XPNPEP2; Xaa-Pro aminopeptidase 2 [EC:3.4.11.9]"]
["ENSRNOG00000021262",3006,193.3772972,1355,87.48131983,2.210498168,1.144371538,{"v":4.0789e-140,"d":"4.08E-140"},{"v":3.3471e-139,"d":"3.35E-139"},"up","yes","Slc23a2","protein_coding","chr3:119302666-119460343:-","gi|347921120|ref|NP_059012.2|",3016,0,"solute carrier family 23 member 2 [Rattus norvegicus]","gi|672046958|ref|XM_006235068.2|",7024,0,"PREDICTED: Rattus norvegicus solute carrier family 23 (ascorbic acid transporter), member 2 (Slc23a2), transcript variant X2, mRNA","Q9WTW8",1166,0,"Solute carrier family 23 member 2","PAB1838",112,{"v":1e-24,"d":"1.00E-24"},"COG2233","pfam00860","Xan_ur_permease","Permease family. This family includes permeases for diverse substrates such as xanthine, uracil, and vitamin C. However many members of this family are functionally uncharacterized and may transport other substrates. Members of this family have ten predicted transmembrane helices.","GO:0006814|sodium ion transport;GO:0006979|response to oxidative stress;GO:0015882|L-ascorbic acid transmembrane transport;GO:0019852|L-ascorbic acid metabolic process;GO:0070904|transepithelial L-ascorbic acid transport;GO:0071361|cellular response to ethanol;GO:1901215|negative regulation of neuron death;GO:1903861|positive regulation of dendrite extension;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009925|basal plasma membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;","GO:0005215|transporter activity;GO:0008520|L-ascorbate:sodium symporter activity;GO:0015229|L-ascorbic acid transmembrane transporter activity;","K23717","SLC23A2, SVCT2; solute carrier family 23 (nucleobase transporter), member 2"]
["ENSRNOG00000067321",619,39.82054124,27,1.743170211,22.84374813,4.513727478,{"v":1.2694E-139,"d":"1.27E-139"},{"v":1.0401e-138,"d":"1.04E-138"},"up","yes","ENSRNOG00000067321","protein_coding","chr16:35360433-35367378:-","gi|33086528|gb|AAP92576.1|",443,{"v":1e-49,"d":"1.00E-49"},"Ab2-051 [Rattus norvegicus]","gi|49615118|gb|AC114512.5|",636,0,"Rattus norvegicus 5 BAC CH230-5N9 (Children's Hospital Oakland Research Institute) complete sequence","P11369",189,{"v":3e-47,"d":"3.00E-47"},"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam10507","DUF2453","Protein of unknown function (DUF2453). Some members of this family are purported to contain GAF domains but this could not be confirmed. The function is not known. It is likely to be a transmembrane protein.",".",".",".",".","."]
["ENSRNOG00000017291",2450,157.6095736,996,64.30361222,2.451022083,1.293383482,{"v":1.4919E-138,"d":"1.49E-138"},{"v":1.212e-137,"d":"1.21E-137"},"up","yes","Sord","protein_coding","chr3:109184676-109216133:+","gi|397357|emb|CAA52670.1|",2025,0,"L-iditol 2-dehydrogenase [Rattus norvegicus]","gi|77404285|ref|NM_017052.2|",2132,0,"Rattus norvegicus sorbitol dehydrogenase (Sord), mRNA","P27867",730,0,"Sorbitol dehydrogenase","YLR070c",300,{"v":7e-93,"d":"7.00E-93"},"COG1063","pfam08240","ADH_N","Alcohol dehydrogenase GroES-like domain. This is the catalytic domain of alcohol dehydrogenases. Many of them contain an inserted zinc binding domain. This domain has a GroES-like structure.","GO:0006060|sorbitol metabolic process;GO:0006062|sorbitol catabolic process;GO:0006970|response to osmotic stress;GO:0009410|response to xenobiotic stimulus;GO:0009725|response to hormone;GO:0030317|flagellated sperm motility;GO:0031667|response to nutrient levels;GO:0046370|fructose biosynthetic process;GO:0046686|response to cadmium ion;GO:0046688|response to copper ion;GO:0051160|L-xylitol catabolic process;GO:0051164|L-xylitol metabolic process;","GO:0005575|cellular_component;GO:0005739|mitochondrion;GO:0016020|membrane;GO:0031514|motile cilium;GO:0031966|mitochondrial membrane;GO:0070062|extracellular exosome;","GO:0003939|L-iditol 2-dehydrogenase activity;GO:0008270|zinc ion binding;GO:0042802|identical protein binding;GO:0046526|D-xylulose reductase activity;GO:0051287|NAD binding;","K00008","SORD, gutB; L-iditol 2-dehydrogenase [EC:1.1.1.14]"]
["ENSRNOG00000056325",1878,120.8125629,643,41.51327576,2.910215123,1.541125801,{"v":2.2223e-138,"d":"2.22E-138"},{"v":1.8029e-137,"d":"1.80E-137"},"up","yes","Mocs2","protein_coding","chr2:46504588-46516324:+","gi|56090313|ref|NP_001007634.1|",1052,{"v":1e-138,"d":"1.00E-138"},"molybdopterin synthase catalytic subunit isoform Mocs2B [Rattus norvegicus]","gi|241666407|ref|NM_001162413.1|",1589,0,"Rattus norvegicus molybdenum cofactor synthesis 2 (Mocs2), transcript variant 1, mRNA","Q6AY59",409,{"v":5e-140,"d":"5.00E-140"},"Molybdopterin synthase catalytic subunit","TVN0087",110,{"v":1E-27,"d":"1.00E-27"},"COG0314","pfam02391","MoaE","MoaE protein. This family contains the MoaE protein that is involved in biosynthesis of molybdopterin. Molybdopterin, the universal component of the pterin molybdenum cofactors, contains a dithiolene group serving to bind Mo. Addition of the dithiolene sulfurs to a molybdopterin precursor requires the activity of the converting factor. Converting factor contains the MoaE and MoaD proteins.","GO:0006777|Mo-molybdopterin cofactor biosynthetic process;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0016607|nuclear speck;GO:0019008|molybdopterin synthase complex;","GO:0003674|molecular_function;GO:0030366|molybdopterin synthase activity;GO:0042802|identical protein binding;","K03635","MOCS2B, moaE; molybdopterin synthase catalytic subunit [EC:2.8.1.12]"]
["ENSRNOG00000009629",1221,78.54746502,283,18.27100628,4.299022386,2.104008623,{"v":5.6713e-138,"d":"5.67E-138"},{"v":4.5879E-137,"d":"4.59E-137"},"up","yes","Car2","protein_coding","chr2:86741626-86756818:-","gi|9506445|ref|NP_062164.1|",1191,{"v":4e-157,"d":"4.00E-157"},"carbonic anhydrase 2 [Rattus norvegicus]","gi|298916112|emb|FQ213417.1|",723,0,"Rattus norvegicus TL0AAA47YP08 mRNA sequence","P27139",463,{"v":1e-158,"d":"1.00E-158"},"Carbonic anhydrase 2","all2929",114,{"v":3e-27,"d":"3.00E-27"},"COG3338","pfam00194","Carb_anhydrase","Eukaryotic-type carbonic anhydrase.","GO:0001822|kidney development;GO:0002009|morphogenesis of an epithelium;GO:0006730|one-carbon metabolic process;GO:0009268|response to pH;GO:0010033|response to organic substance;GO:0010043|response to zinc ion;GO:0015670|carbon dioxide transport;GO:0030316|osteoclast differentiation;GO:0030641|regulation of cellular pH;GO:0032230|positive regulation of synaptic transmission, GABAergic;GO:0032849|positive regulation of cellular pH reduction;GO:0038166|angiotensin-activated signaling pathway;GO:0042475|odontogenesis of dentin-containing tooth;GO:0043627|response to estrogen;GO:0044070|regulation of anion transport;GO:0045124|regulation of bone resorption;GO:0045672|positive regulation of osteoclast differentiation;GO:0045780|positive regulation of bone resorption;GO:0046903|secretion;GO:0048545|response to steroid hormone;GO:0051453|regulation of intracellular pH;GO:0071498|cellular response to fluid shear stress;GO:2001150|positive regulation of dipeptide transmembrane transport;GO:2001225|regulation of chloride transport;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005902|microvillus;GO:0016323|basolateral plasma membrane;GO:0030424|axon;GO:0043209|myelin sheath;GO:0045177|apical part of cell;","GO:0004064|arylesterase activity;GO:0004089|carbonate dehydratase activity;GO:0005515|protein binding;GO:0008270|zinc ion binding;GO:0016836|hydro-lyase activity;","K18245","CA2; carbonic anhydrase 2 [EC:4.2.1.1]"]
["ENSRNOG00000007545",2113,135.9302159,789,50.93930727,2.668473978,1.416014943,{"v":2.7636e-137,"d":"2.76E-137"},{"v":2.2231e-136,"d":"2.22E-136"},"up","yes","Angptl4","protein_coding","chr7:14550311-14556519:-","gi|40018598|ref|NP_954546.1|",1972,0,"angiopoietin-related protein 4 precursor [Rattus norvegicus]","gi|51036687|ref|NM_199115.2|",1825,0,"Rattus norvegicus angiopoietin-like 4 (Angptl4), mRNA","Q6TMA8",764,0,"Angiopoietin-related protein 4",".",".",".",".","pfam00147","Fibrinogen_C","Fibrinogen beta and gamma chains, C-terminal globular domain.","GO:0001525|angiogenesis;GO:0001666|response to hypoxia;GO:0006629|lipid metabolic process;GO:0019216|regulation of lipid metabolic process;GO:0043066|negative regulation of apoptotic process;GO:0043086|negative regulation of catalytic activity;GO:0043335|protein unfolding;GO:0051005|negative regulation of lipoprotein lipase activity;GO:0070328|triglyceride homeostasis;GO:2000352|negative regulation of endothelial cell apoptotic process;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0062023|collagen-containing extracellular matrix;","GO:0004857|enzyme inhibitor activity;GO:0005102|signaling receptor binding;GO:0042802|identical protein binding;","K08767","ANGPTL4, PGAR; angiopoietin-like 4"]
["ENSRNOG00000012860",2769,178.1309833,1210,78.11985018,2.280226894,1.189177387,{"v":2.888E-137,"d":"2.89E-137"},{"v":2.3198E-136,"d":"2.32E-136"},"up","yes","Tmem184c","protein_coding","chr19:30345290-30361269:+","gi|672084742|ref|XP_008770697.1|",2398,0,"PREDICTED: transmembrane protein 184C isoform X2 [Rattus norvegicus]","gi|672084741|ref|XM_008772475.1|",2874,0,"PREDICTED: Rattus norvegicus transmembrane protein 184C (Tmem184c), transcript variant X2, mRNA","Q810F5",920,0,"Transmembrane protein 184C",".",".",".",".","pfam03619","Solute_trans_a","Organic solute transporter Ostalpha. This family is a transmembrane organic solute transport protein. In vertebrates these proteins form a complex with Ostbeta, and function as bile transporters. In plants they may transport brassinosteroid-like compounds and act as regulators of cell death.","GO:0006810|transport;","GO:0016021|integral component of membrane;","GO:0005215|transporter activity;",".","."]
["ENSRNOG00000012999",3329,214.1560287,1591,102.7179187,2.084894548,1.059974415,{"v":3.9916e-137,"d":"3.99E-137"},{"v":3.1973e-136,"d":"3.20E-136"},"up","yes","Phb2","protein_coding","chr4:157517577-157522272:+","gi|795107656|ref|XP_011807801.1|",1086,{"v":5e-142,"d":"5.00E-142"},"PREDICTED: prohibitin-2 isoform X2 [Colobus angolensis palliatus]","gi|61556753|ref|NM_001013035.1|",748,0,"Rattus norvegicus prohibitin 2 (Phb2), mRNA","Q5XIH7",410,{"v":2e-138,"d":"2.00E-138"},"Prohibitin-2","YGR231c",229,{"v":6e-69,"d":"6.00E-69"},"COG0330","pfam01145","Band_7","SPFH domain / Band 7 family. This family has been called SPFH, Band 7 or PHB domain. Recent phylogenetic analysis has shown this domain to be a slipin or Stomatin-like integral membrane domain conserved from protozoa to mammals.","GO:0000423|mitophagy;GO:0002639|positive regulation of immunoglobulin production;GO:0006606|protein import into nucleus;GO:0007005|mitochondrion organization;GO:0007062|sister chromatid cohesion;GO:0007202|activation of phospholipase C activity;GO:0009611|response to wounding;GO:0016477|cell migration;GO:0023035|CD40 signaling pathway;GO:0031536|positive regulation of exit from mitosis;GO:0033147|negative regulation of intracellular estrogen receptor signaling pathway;GO:0033600|negative regulation of mammary gland epithelial cell proliferation;GO:0039529|RIG-I signaling pathway;GO:0042113|B cell activation;GO:0043066|negative regulation of apoptotic process;GO:0043433|negative regulation of DNA-binding transcription factor activity;GO:0045892|negative regulation of transcription, DNA-templated;GO:0050821|protein stabilization;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0060744|mammary gland branching involved in thelarche;GO:0060749|mammary gland alveolus development;GO:0060762|regulation of branching involved in mammary gland duct morphogenesis;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071300|cellular response to retinoic acid;GO:0071456|cellular response to hypoxia;GO:1900208|regulation of cardiolipin metabolic process;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1902808|positive regulation of cell cycle G1/S phase transition;GO:1904959|regulation of cytochrome-c oxidase activity;GO:1990051|activation of protein kinase C activity;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0005743|mitochondrial inner membrane;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0014069|postsynaptic density;GO:0016363|nuclear matrix;GO:0030424|axon;GO:0032991|protein-containing complex;GO:0035632|mitochondrial prohibitin complex;GO:0048786|presynaptic active zone;GO:0071944|cell periphery;GO:0098800|inner mitochondrial membrane protein complex;GO:0098978|glutamatergic synapse;GO:0098982|GABA-ergic synapse;","GO:0003674|molecular_function;GO:0008022|protein C-terminus binding;GO:0033218|amide binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0046625|sphingolipid binding;GO:0046982|protein heterodimerization activity;GO:0047485|protein N-terminus binding;","K17081","PHB2; prohibitin 2"]
["ENSRNOG00000019328",1021,65.68137739,192,12.39587705,5.29864705,2.405624031,{"v":6.9953e-136,"d":"7.00E-136"},{"v":5.5721E-135,"d":"5.57E-135"},"up","yes","Phgdh","protein_coding","chr2:185906966-185935944:-","gi|13928850|ref|NP_113808.1|",2480,0,"D-3-phosphoglycerate dehydrogenase [Rattus norvegicus]","gi|564338012|ref|XM_006233010.1|",1546,0,"PREDICTED: Rattus norvegicus phosphoglycerate dehydrogenase (Phgdh), transcript variant X1, mRNA","O08651",959,0,"D-3-phosphoglycerate dehydrogenase","MJ1018",327,{"v":1e-102,"d":"1.00E-102"},"COG0111","pfam00389","2-Hacid_dh","D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. This family represents the largest portion of the catalytic domain of 2-hydroxyacid dehydrogenases as the NAD binding domain is inserted within the structural domain.","GO:0006541|glutamine metabolic process;GO:0006544|glycine metabolic process;GO:0006563|L-serine metabolic process;GO:0006564|L-serine biosynthetic process;GO:0006566|threonine metabolic process;GO:0009070|serine family amino acid biosynthetic process;GO:0009448|gamma-aminobutyric acid metabolic process;GO:0010468|regulation of gene expression;GO:0019530|taurine metabolic process;GO:0021510|spinal cord development;GO:0021782|glial cell development;GO:0021915|neural tube development;GO:0022008|neurogenesis;GO:0031175|neuron projection development;GO:0070314|G1 to G0 transition;","GO:0005575|cellular_component;","GO:0004617|phosphoglycerate dehydrogenase activity;GO:0051287|NAD binding;","K00058","serA, PHGDH; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]"]
["ENSRNOG00000000701",3339,214.7993331,1609,103.8800322,2.067763444,1.048071148,{"v":4.7224e-135,"d":"4.72E-135"},{"v":3.7408e-134,"d":"3.74E-134"},"up","yes","Iscu","protein_coding","chr12:42852305-42858150:-","gi|157786934|ref|NP_001099406.1|",747,{"v":3e-96,"d":"3.00E-96"},"iron-sulfur cluster assembly enzyme ISCU, mitochondrial [Rattus norvegicus]","gi|157786933|ref|NM_001105936.1|",924,0,"Rattus norvegicus iron-sulfur cluster assembly enzyme (Iscu), mRNA","Q9D7P6",289,{"v":1e-96,"d":"1.00E-96"},"Iron-sulfur cluster assembly enzyme ISCU, mitochondrial","RC0729",224,{"v":3e-72,"d":"3.00E-72"},"COG0822","pfam01592","NifU_N","NifU-like N terminal domain. This domain is found in NifU in combination with pfam01106. This domain is found on isolated in several bacterial species. The nif genes are responsible for nitrogen fixation. However this domain is found in bacteria that do not fix nitrogen, so it may have a broader significance in the cell than nitrogen fixation. These proteins appear to be scaffold proteins for iron-sulfur clusters.","GO:0006879|cellular iron ion homeostasis;GO:0016226|iron-sulfur cluster assembly;GO:1902958|positive regulation of mitochondrial electron transport, NADH to ubiquinone;GO:1904234|positive regulation of aconitate hydratase activity;GO:1904439|negative regulation of ferrous iron import across plasma membrane;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005759|mitochondrial matrix;GO:0005829|cytosol;","GO:0008198|ferrous iron binding;GO:0051537|2 iron, 2 sulfur cluster binding;GO:0060090|molecular adaptor activity;","K22068","ISCU; iron-sulfur cluster assembly enzyme ISCU, mitochondrial"]
["ENSRNOG00000055314",2235,143.7785293,874,56.42706534,2.548041945,1.349389027,{"v":5.5332e-135,"d":"5.53E-135"},{"v":4.377e-134,"d":"4.38E-134"},"up","yes","Msrb1","protein_coding","chr10:13764883-13770609:+","gi|146229350|ref|NP_001037750.2|",603,{"v":2e-75,"d":"2.00E-75"},"methionine-R-sulfoxide reductase B1 [Rattus norvegicus]","gi|146229349|ref|NM_001044285.2|",872,0,"Rattus norvegicus methionine sulfoxide reductase B1 (Msrb1), mRNA","Q52KJ8",236,{"v":6e-77,"d":"6.00E-77"},"Methionine-R-sulfoxide reductase B1","MA0449",66.6,{"v":1e-12,"d":"1.00E-12"},"COG0229","pfam01641","SelR","SelR domain. Methionine sulfoxide reduction is an important process, by which cells regulate biological processes and cope with oxidative stress. MsrA, a protein involved in the reduction of methionine sulfoxides in proteins, has been known for four decades and has been extensively characterized with respect to structure and function. However, recent studies revealed that MsrA is only specific for methionine-S-sulfoxides. Because oxidized methionines occur in a mixture of R and S isomers in vivo, it was unclear how stereo-specific MsrA could be responsible for the reduction of all protein methionine sulfoxides. It appears that a second methionine sulfoxide reductase, SelR, evolved that is specific for methionine-R-sulfoxides, the activity that is different but complementary to that of MsrA. Thus, these proteins, working together, could reduce both stereoisomers of methionine sulfoxide. This domain is found both in SelR proteins and fused with the peptide methionine sulfoxide reductase enzymatic domain pfam01625. The domain has two conserved cysteine and histidines. The domain binds both selenium and zinc. The final cysteine is found to be replaced by the rare amino acid selenocysteine in some members of the family. This family has methionine-R-sulfoxide reductase activity.","GO:0030041|actin filament polymerization;GO:0030091|protein repair;GO:0045087|innate immune response;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0015629|actin cytoskeleton;","GO:0003779|actin binding;GO:0008270|zinc ion binding;GO:0033743|peptide-methionine (R)-S-oxide reductase activity;GO:0033745|L-methionine-(R)-S-oxide reductase activity;GO:0070191|methionine-R-sulfoxide reductase activity;","K07305","msrB; peptide-methionine (R)-S-oxide reductase [EC:1.8.4.12]"]
["ENSRNOG00000007687",2993,192.5410015,1374,88.70799517,2.170503359,1.118029655,{"v":1.8274E-134,"d":"1.83E-134"},{"v":1.4396E-133,"d":"1.44E-133"},"up","yes","Sema7a","protein_coding","chr8:58348448-58370536:+","gi|209863068|ref|NP_001101623.1|",3362,0,"semaphorin-7A precursor [Rattus norvegicus]","gi|209863067|ref|NM_001108153.1|",2622,0,"Rattus norvegicus semaphorin 7A, GPI membrane anchor (Sema7a), mRNA","Q9QUR8",1264,0,"Semaphorin-7A",".",".",".",".","pfam01403","Sema","Sema domain. The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and human plexin A-3.","GO:0001755|neural crest cell migration;GO:0001934|positive regulation of protein phosphorylation;GO:0007229|integrin-mediated signaling pathway;GO:0007411|axon guidance;GO:0021988|olfactory lobe development;GO:0030335|positive regulation of cell migration;GO:0031175|neuron projection development;GO:0045773|positive regulation of axon extension;GO:0048675|axon extension;GO:0048843|negative regulation of axon extension involved in axon guidance;GO:0050727|regulation of inflammatory response;GO:0050919|negative chemotaxis;GO:0060907|positive regulation of macrophage cytokine production;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071526|semaphorin-plexin signaling pathway;","GO:0005615|extracellular space;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;","GO:0005178|integrin binding;GO:0030215|semaphorin receptor binding;GO:0045499|chemorepellent activity;","K06529","SEMA7, CD108; semaphorin 7"]
["ENSRNOG00000024349",1249,80.34871729,306,19.75592905,4.067068528,2.0239893,{"v":2.4791e-134,"d":"2.48E-134"},{"v":1.9476e-133,"d":"1.95E-133"},"up","yes","Cbarp","protein_coding","chr7:9566364-9575204:+","gi|568966130|ref|XP_006513030.1|",2374,0,"PREDICTED: protein Dos isoform X2 [Mus musculus]","gi|755533718|ref|XM_006512965.2|",2457,0,"PREDICTED: Mus musculus downstream of Stk11 (Dos), transcript variant X1, mRNA","Q66L44",915,0,"Voltage-dependent calcium channel beta subunit-associated regulatory protein",".",".",".",".","pfam05642","Sporozoite_P67","Sporozoite P67 surface antigen. This family consists of several Theileria P67 surface antigens. A stage specific surface antigen of Theileria parva, p67, is the basis for the development of an anti-sporozoite vaccine for the control of East Coast fever (ECF) in cattle. The antigen has been shown to contain five distinct linear peptide sequences recognized by sporozoite-neutralizing murine monoclonal antibodies.","GO:0045955|negative regulation of calcium ion-dependent exocytosis;GO:1901386|negative regulation of voltage-gated calcium channel activity;GO:1903170|negative regulation of calcium ion transmembrane transport;","GO:0005886|plasma membrane;GO:0030141|secretory granule;GO:0030426|growth cone;","GO:0044325|ion channel binding;",".","."]
["ENSRNOG00000020032",3283,211.1968286,1574,101.6203671,2.078292321,1.05539859,{"v":2.5518e-134,"d":"2.55E-134"},{"v":2.0019e-133,"d":"2.00E-133"},"up","yes","Impdh1","protein_coding","chr4:57801831-57819076:-","gi|564346098|ref|XP_006236270.1|",3182,0,"PREDICTED: inosine-5'-monophosphate dehydrogenase 1 isoform X2 [Rattus norvegicus]","gi|564346097|ref|XM_006236208.1|",2678,0,"PREDICTED: Rattus norvegicus IMP (inosine 5'-monophosphate) dehydrogenase 1 (Impdh1), transcript variant X2, mRNA","D3ZLZ7",1039,0,"Inosine-5'-monophosphate dehydrogenase 1",".",".",".",".","pfam00478","IMPDH","IMP dehydrogenase / GMP reductase domain. This family is involved in biosynthesis of guanosine nucleotide. Members of this family contain a TIM barrel structure. In the inosine monophosphate dehydrogenases 2 CBS domains pfam00571 are inserted in the TIM barrel. This family is a member of the common phosphate binding site TIM barrel family.","GO:0006164|purine nucleotide biosynthetic process;GO:0006177|GMP biosynthetic process;GO:0006183|GTP biosynthetic process;GO:0009409|response to cold;GO:0046651|lymphocyte proliferation;GO:0060041|retina development in camera-type eye;GO:0097294|'de novo' XMP biosynthetic process;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0000166|nucleotide binding;GO:0003674|molecular_function;GO:0003676|nucleic acid binding;GO:0003677|DNA binding;GO:0003938|IMP dehydrogenase activity;GO:0042802|identical protein binding;GO:0046872|metal ion binding;","K00088","IMPDH, guaB; IMP dehydrogenase [EC:1.1.1.205]"]
["ENSRNOG00000011631",2903,186.7512621,1314,84.83428359,2.201365464,1.138398677,{"v":2.8746e-134,"d":"2.87E-134"},{"v":2.2521e-133,"d":"2.25E-133"},"up","yes","Fst","protein_coding","chr2:46123439-46130571:-","gi|6978857|ref|NP_036693.1|",1688,0,"follistatin precursor [Rattus norvegicus]","gi|672041459|ref|XM_006231953.2|",2011,0,"PREDICTED: Rattus norvegicus follistatin (Fst), transcript variant X1, mRNA","P21674",653,0,"Follistatin",".",".",".",".","pfam07648","Kazal_2","Kazal-type serine protease inhibitor domain. Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001501|skeletal system development;GO:0002244|hematopoietic progenitor cell differentiation;GO:0007275|multicellular organism development;GO:0007276|gamete generation;GO:0007389|pattern specification process;GO:0008585|female gonad development;GO:0030154|cell differentiation;GO:0030509|BMP signaling pathway;GO:0030510|regulation of BMP signaling pathway;GO:0031069|hair follicle morphogenesis;GO:0032926|negative regulation of activin receptor signaling pathway;GO:0042475|odontogenesis of dentin-containing tooth;GO:0043616|keratinocyte proliferation;GO:0045596|negative regulation of cell differentiation;GO:0046882|negative regulation of follicle-stimulating hormone secretion;GO:0051798|positive regulation of hair follicle development;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0005515|protein binding;GO:0038102|activin receptor antagonist activity;GO:0043395|heparan sulfate proteoglycan binding;GO:0048185|activin binding;","K04661","FST; follistatin"]
["ENSRNOG00000020579",2234,143.7141989,879,56.74987464,2.532414385,1.340513496,{"v":1.384E-133,"d":"1.38E-133"},{"v":1.0784E-132,"d":"1.08E-132"},"up","yes","Col7a1","protein_coding","chr8:109604861-109637252:+","gi|157819015|ref|NP_001100328.1|",6441,0,"collagen alpha-1(VII) chain precursor [Rattus norvegicus]","gi|672062939|ref|XM_006243759.2|",9219,0,"PREDICTED: Rattus norvegicus collagen, type VII, alpha 1 (Col7a1), transcript variant X1, mRNA","Q63870",2256,0,"Collagen alpha-1(VII) chain",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0008150|biological_process;GO:0035987|endodermal cell differentiation;","GO:0005575|cellular_component;GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0062023|collagen-containing extracellular matrix;","GO:0003674|molecular_function;GO:0042802|identical protein binding;","K16628","COL7A; collagen type VII alpha"]
["ENSRNOG00000059445",1900,122.2278326,677,43.70837899,2.796439387,1.48359106,{"v":1.9204e-132,"d":"1.92E-132"},{"v":1.4841E-131,"d":"1.48E-131"},"up","yes","Aifm2","protein_coding","chr20:29652927-29679236:+","gi|564397948|ref|XP_006256515.1|",1844,0,"PREDICTED: apoptosis-inducing factor 2 isoform X2 [Rattus norvegicus]","gi|672086246|ref|XM_006256453.2|",3404,0,"PREDICTED: Rattus norvegicus apoptosis-inducing factor, mitochondrion-associated 2 (Aifm2), transcript variant X3, mRNA","Q8BUE4",694,0,"Apoptosis-inducing factor 2","DR0950",71.6,{"v":3e-12,"d":"3.00E-12"},"COG1252","pfam07992","Pyr_redox_2","Pyridine nucleotide-disulphide oxidoreductase. This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.","GO:0006743|ubiquinone metabolic process;GO:0008637|apoptotic mitochondrial changes;GO:0022904|respiratory electron transport chain;GO:0043065|positive regulation of apoptotic process;GO:0110076|negative regulation of ferroptosis;GO:1900407|regulation of cellular response to oxidative stress;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0005811|lipid droplet;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0031966|mitochondrial membrane;","GO:0003677|DNA binding;GO:0004174|electron-transferring-flavoprotein dehydrogenase activity;GO:0016655|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0050660|flavin adenine dinucleotide binding;","K22745","AIFM2; apoptosis-inducing factor 2"]
["ENSRNOG00000003979",1280,82.34296088,327,21.11172811,3.90034205,1.96360065,{"v":2.4091E-132,"d":"2.41E-132"},{"v":1.8594e-131,"d":"1.86E-131"},"up","yes","Zranb3","protein_coding","chr13:39440889-39595670:-","gi|564380349|ref|XP_006249763.1|",5538,0,"PREDICTED: DNA annealing helicase and endonuclease ZRANB3 isoform X2 [Rattus norvegicus]","gi|672073926|ref|XM_006249702.2|",3994,0,"PREDICTED: Rattus norvegicus zinc finger, RAN-binding domain containing 3 (Zranb3), transcript variant X3, mRNA","Q6NZP1",1860,0,"DNA annealing helicase and endonuclease ZRANB3","ECU06g0820",307,{"v":2E-90,"d":"2.00E-90"},"COG0553","pfam00176","SNF2_N","SNF2 family N-terminal domain. This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1).","GO:0006281|DNA repair;GO:0006974|cellular response to DNA damage stimulus;GO:0009411|response to UV;GO:0031297|replication fork processing;GO:0036292|DNA rewinding;GO:0045910|negative regulation of DNA recombination;GO:0048478|replication fork protection;GO:0090305|nucleic acid phosphodiester bond hydrolysis;","GO:0005654|nucleoplasm;GO:0043596|nuclear replication fork;","GO:0004520|endodeoxyribonuclease activity;GO:0005524|ATP binding;GO:0036310|annealing helicase activity;GO:0046872|metal ion binding;GO:0070530|K63-linked polyubiquitin modification-dependent protein binding;",".","."]
["ENSRNOG00000014900",1766,113.6075538,603,38.93080137,2.918192018,1.545074816,{"v":9.975e-131,"d":"9.98E-131"},{"v":7.6573e-130,"d":"7.66E-130"},"up","yes","Crem","protein_coding","chr17:54239030-54305989:+","gi|402746664|ref|NP_001258030.1|",1523,0,"cAMP-responsive element modulator isoform 4 [Rattus norvegicus]","gi|402746663|ref|NM_001271101.1|",3614,0,"Rattus norvegicus cAMP responsive element modulator (Crem), transcript variant 4, mRNA","Q03061",591,0,"cAMP-responsive element modulator",".",".",".",".","pfam02173","pKID","pKID domain. CBP and P300 bind to the pKID (phosphorylated kinase-inducible-domain) domain of CREB.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006006|glucose metabolic process;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006631|fatty acid metabolic process;GO:0006687|glycosphingolipid metabolic process;GO:0007283|spermatogenesis;GO:0007623|circadian rhythm;GO:0019933|cAMP-mediated signaling;GO:0032922|circadian regulation of gene expression;GO:0042752|regulation of circadian rhythm;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048384|retinoic acid receptor signaling pathway;GO:0051591|response to cAMP;","GO:0005634|nucleus;GO:0005667|transcription factor complex;GO:0005737|cytoplasm;GO:1990589|ATF4-CREB1 transcription factor complex;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:1990837|sequence-specific double-stranded DNA binding;","K09052","CREM; cAMP response element modulator"]
["ENSRNOG00000028837",1413,90.89890916,403,26.01842944,3.493635516,1.804729102,{"v":1.9901E-130,"d":"1.99E-130"},{"v":1.5236e-129,"d":"1.52E-129"},"up","yes","AC128207.1","protein_coding","chr7:914081-917294:-","gi|149029675|gb|EDL84846.1|",1009,{"v":1E-134,"d":"1.00E-134"},"similar to Myosin light chain 1 slow a (predicted) [Rattus norvegicus]","gi|26986554|ref|NM_172259.1|",611,0,"Mus musculus myosin, light polypeptide 6B (Myl6b), mRNA","Q8CI43",348,{"v":1e-118,"d":"1.00E-118"},"Myosin light chain 6B","SPAC3A12.14",112,{"v":8e-29,"d":"8.00E-29"},"COG5126","pfam13499","EF-hand_7","EF-hand domain pair.",".",".",".",".","."]
["ENSRNOG00000011200",770,49.5344374,95,6.133376667,8.076209907,3.013678408,{"v":2.3758e-130,"d":"2.38E-130"},{"v":1.8165E-129,"d":"1.82E-129"},"up","yes","Bhmt","protein_coding","chr2:24859873-24879742:-","gi|49259376|pdb|1UMY|A",2120,0,"Chain A, Bhmt From Rat Liver","gi|50926805|gb|BC078811.1|",1850,0,"Rattus norvegicus betaine-homocysteine methyltransferase, mRNA (cDNA clone MGC:93402 IMAGE:7130736), complete cds","O09171",816,0,"Betaine--homocysteine S-methyltransferase 1","BS_yitJ_1",96.3,{"v":7e-21,"d":"7.00E-21"},"COG0646","pfam02574","S-methyl_trans","Homocysteine S-methyltransferase. This is a family of related homocysteine S-methyltransferases enzymes: 5-methyltetrahydrofolate--homocysteine S-methyltransferases also known EC:2.1.1.13; Betaine--homocysteine S-methyltransferase (vitamin B12 dependent), EC:2.1.1.5,; and Homocysteine S-methyltransferase, EC:2.1.1.10,.","GO:0006479|protein methylation;GO:0006577|amino-acid betaine metabolic process;GO:0006579|amino-acid betaine catabolic process;GO:0009086|methionine biosynthetic process;GO:0010243|response to organonitrogen compound;GO:0032259|methylation;GO:0071267|L-methionine salvage;","GO:0005829|cytosol;GO:0032991|protein-containing complex;GO:0070062|extracellular exosome;","GO:0008168|methyltransferase activity;GO:0008270|zinc ion binding;GO:0044877|protein-containing complex binding;GO:0047150|betaine-homocysteine S-methyltransferase activity;","K00544","BHMT; betaine-homocysteine S-methyltransferase [EC:2.1.1.5]"]
["ENSRNOG00000031367",2833,182.2481314,1289,83.2202371,2.189949677,1.130897719,{"v":1.0285E-129,"d":"1.03E-129"},{"v":7.822e-129,"d":"7.82E-129"},"up","yes","Hprt1","protein_coding","chrX:132736096-132768154:+","gi|51092266|ref|NP_036715.1|",1071,{"v":8e-141,"d":"8.00E-141"},"hypoxanthine-guanine phosphoribosyltransferase [Rattus norvegicus]","gi|672089059|ref|XM_008773659.1|",1140,0,"PREDICTED: Rattus norvegicus hypoxanthine-guanine phosphoribosyltransferase (LOC103689983), mRNA","P27605",417,{"v":3e-142,"d":"3.00E-142"},"Hypoxanthine-guanine phosphoribosyltransferase","lin0251_2",116,{"v":3e-29,"d":"3.00E-29"},"COG0634","pfam00156","Pribosyltran","Phosphoribosyl transferase domain. This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.","GO:0001913|T cell mediated cytotoxicity;GO:0001975|response to amphetamine;GO:0006164|purine nucleotide biosynthetic process;GO:0006166|purine ribonucleoside salvage;GO:0006168|adenine salvage;GO:0006178|guanine salvage;GO:0007283|spermatogenesis;GO:0007420|brain development;GO:0007625|grooming behavior;GO:0007626|locomotory behavior;GO:0021756|striatum development;GO:0021895|cerebral cortex neuron differentiation;GO:0021954|central nervous system neuron development;GO:0032263|GMP salvage;GO:0032264|IMP salvage;GO:0032869|cellular response to insulin stimulus;GO:0042417|dopamine metabolic process;GO:0043103|hypoxanthine salvage;GO:0044209|AMP salvage;GO:0045964|positive regulation of dopamine metabolic process;GO:0046038|GMP catabolic process;GO:0046040|IMP metabolic process;GO:0046083|adenine metabolic process;GO:0046100|hypoxanthine metabolic process;GO:0046651|lymphocyte proliferation;GO:0048813|dendrite morphogenesis;GO:0051289|protein homotetramerization;","GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0000166|nucleotide binding;GO:0000287|magnesium ion binding;GO:0004422|hypoxanthine phosphoribosyltransferase activity;GO:0042802|identical protein binding;GO:0052657|guanine phosphoribosyltransferase activity;","K00760","hprT, hpt, HPRT1; hypoxanthine phosphoribosyltransferase [EC:2.4.2.8]"]
["ENSRNOG00000001525",3302,212.4191069,1613,104.1382796,2.039779298,1.028413062,{"v":1.4867e-129,"d":"1.49E-129"},{"v":1.1291E-128,"d":"1.13E-128"},"up","yes","Igsf11","protein_coding","chr11:61733144-61868348:-","gi|61557018|ref|NP_001013138.1|",1840,0,"immunoglobulin superfamily member 11 precursor [Rattus norvegicus]","gi|61557017|ref|NM_001013120.1|",3616,0,"Rattus norvegicus immunoglobulin superfamily, member 11 (Igsf11), mRNA","Q5U2P2",713,0,"Immunoglobulin superfamily member 11",".",".",".",".","pfam13927","Ig_3","Immunoglobulin domain. This family contains immunoglobulin-like domains.","GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0040008|regulation of growth;GO:0045185|maintenance of protein location;GO:0048167|regulation of synaptic plasticity;GO:0061885|positive regulation of mini excitatory postsynaptic potential;GO:1900273|positive regulation of long-term synaptic potentiation;","GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0014069|postsynaptic density;GO:0016021|integral component of membrane;GO:0060076|excitatory synapse;","GO:0005515|protein binding;GO:0035255|ionotropic glutamate receptor binding;","K06791","IGSF11; immunoglobulin superfamily, member 11"]
["ENSRNOG00000000800",2893,186.1079577,1334,86.12552078,2.160892102,1.111627037,{"v":7.4032e-129,"d":"7.40E-129"},{"v":5.6003e-128,"d":"5.60E-128"},"up","yes","Man1a1","protein_coding","chr20:33202517-33385824:-","gi|564398053|ref|XP_006256559.1|",3676,0,"PREDICTED: mannosyl-oligosaccharide 1,2-alpha-mannosidase IA isoform X1 [Rattus norvegicus]","gi|75905482|ref|NM_001033656.1|",3857,0,"Rattus norvegicus mannosidase, alpha, class 1A, member 1 (Man1a1), mRNA","P45700",1238,0,"Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA",".",".",".",".","pfam01532","Glyco_hydro_47","Glycosyl hydrolase family 47. Members of this family are alpha-mannosidases that catalyse the hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2).","GO:0005975|carbohydrate metabolic process;GO:0006491|N-glycan processing;GO:0030433|ubiquitin-dependent ERAD pathway;GO:0045047|protein targeting to ER;GO:1904382|mannose trimming involved in glycoprotein ERAD pathway;","GO:0000139|Golgi membrane;GO:0005783|endoplasmic reticulum;GO:0005793|endoplasmic reticulum-Golgi intermediate compartment;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0016021|integral component of membrane;GO:0031410|cytoplasmic vesicle;","GO:0004571|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity;GO:0005509|calcium ion binding;","K01230","MAN1A_C, MNS1_2; mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113]"]
["ENSRNOG00000006027",1983,127.5672589,742,47.90489986,2.662927159,1.413012966,{"v":1.4847E-128,"d":"1.48E-128"},{"v":1.1201e-127,"d":"1.12E-127"},"up","yes","Eif2ak4","protein_coding","chr3:105356261-105441630:+","gi|309319799|ref|NP_001099214.2|",8144,0,"eIF-2-alpha kinase GCN2 [Rattus norvegicus]","gi|309319798|ref|NM_001105744.2|",5225,0,"Rattus norvegicus eukaryotic translation initiation factor 2 alpha kinase 4 (Eif2ak4), mRNA","D4A7V9",3137,0,"eIF-2-alpha kinase GCN2",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0000077|DNA damage checkpoint;GO:0001934|positive regulation of protein phosphorylation;GO:0002230|positive regulation of defense response to virus by host;GO:0002286|T cell activation involved in immune response;GO:0002821|positive regulation of adaptive immune response;GO:0006468|protein phosphorylation;GO:0007612|learning;GO:0007616|long-term memory;GO:0009267|cellular response to starvation;GO:0010628|positive regulation of gene expression;GO:0010998|regulation of translational initiation by eIF2 alpha phosphorylation;GO:0017148|negative regulation of translation;GO:0019081|viral translation;GO:0030968|endoplasmic reticulum unfolded protein response;GO:0032057|negative regulation of translational initiation in response to stress;GO:0032792|negative regulation of CREB transcription factor activity;GO:0034198|cellular response to amino acid starvation;GO:0034644|cellular response to UV;GO:0034976|response to endoplasmic reticulum stress;GO:0036492|eiF2alpha phosphorylation in response to endoplasmic reticulum stress;GO:0043558|regulation of translational initiation in response to stress;GO:0044828|negative regulation by host of viral genome replication;GO:0045665|negative regulation of neuron differentiation;GO:0045947|negative regulation of translational initiation;GO:0046777|protein autophosphorylation;GO:0060259|regulation of feeding behavior;GO:0070417|cellular response to cold;GO:0071264|positive regulation of translational initiation in response to starvation;GO:1900273|positive regulation of long-term synaptic potentiation;GO:1990138|neuron projection extension;GO:1990253|cellular response to leucine starvation;","GO:0005829|cytosol;GO:0005844|polysome;","GO:0000049|tRNA binding;GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0004694|eukaryotic translation initiation factor 2alpha kinase activity;GO:0005524|ATP binding;","K16196","EIF2AK4; eukaryotic translation initiation factor 2-alpha kinase 4 [EC:2.7.11.1]"]
["ENSRNOG00000046002",3043,195.7575234,1442,93.09820162,2.1026993,1.07224255,{"v":7.4538e-128,"d":"7.45E-128"},{"v":5.5867e-127,"d":"5.59E-127"},"up","yes","Micos13","protein_coding","chr9:1439058-1442076:-","gi|197385539|ref|NP_001128005.1|",677,{"v":3e-82,"d":"3.00E-82"},"protein QIL1 [Rattus norvegicus]","gi|197385538|ref|NM_001134533.1|",1246,0,"Rattus norvegicus hypothetical LOC301124 (LOC301124), mRNA","Q8R404",215,{"v":4e-65,"d":"4.00E-65"},"MICOS complex subunit MIC13",".",".",".",".","pfam15301","SLAIN","SLAIN motif-containing family. The SLAIN motif containing family is named after the presence of a SLAIN motif in SLAIN1. They are a family of microtubule plus-end tracking proteins.","GO:0042407|cristae formation;","GO:0005654|nucleoplasm;GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0044284|mitochondrial crista junction;GO:0061617|MICOS complex;",".",".","."]
["ENSRNOG00000058193",1185,76.23156925,290,18.7229393,4.071559921,2.025581634,{"v":1.1152e-127,"d":"1.12E-127"},{"v":8.3261e-127,"d":"8.33E-127"},"up","yes","Slc27a6","protein_coding","chr18:52041074-52099414:+","gi|157817642|ref|NP_001099615.1|",3312,0,"long-chain fatty acid transport protein 6 [Rattus norvegicus]","gi|157817641|ref|NM_001106145.1|",2603,0,"Rattus norvegicus solute carrier family 27 (fatty acid transporter), member 6 (Slc27a6), mRNA","Q9Y2P4",1040,0,"Long-chain fatty acid transport protein 6",".",".",".",".","pfam00501","AMP-binding","AMP-binding enzyme.","GO:0001676|long-chain fatty acid metabolic process;GO:0008150|biological_process;GO:0015909|long-chain fatty acid transport;","GO:0005575|cellular_component;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0004467|long-chain fatty acid-CoA ligase activity;GO:0005324|long-chain fatty acid transporter activity;GO:0031957|very long-chain fatty acid-CoA ligase activity;","K08749","SLC27A6, FATP6; solute carrier family 27 (fatty acid transporter), member 6"]
["ENSRNOG00000013376",1145,73.65835172,271,17.49626397,4.209947441,2.073802222,{"v":3.5392e-127,"d":"3.54E-127"},{"v":2.6251E-126,"d":"2.63E-126"},"up","yes","Mvd","protein_coding","chr19:50496367-50507971:-","gi|51980639|gb|AAH81784.1|",1984,0,"Mevalonate (diphospho) decarboxylase [Rattus norvegicus]","gi|672085338|ref|XR_361902.2|",1783,0,"PREDICTED: Rattus norvegicus mevalonate (diphospho) decarboxylase (Mvd), transcript variant X1, misc_RNA","Q62967",766,0,"Diphosphomevalonate decarboxylase","SPAC24C9.03",336,{"v":1e-104,"d":"1.00E-104"},"COG3407","pfam12340","DUF3638","Protein of unknown function (DUF3638). This domain family is found in eukaryotes, and is approximately 230 amino acids in length. There are two conserved sequence motifs: LLE and NMG.","GO:0006695|cholesterol biosynthetic process;GO:0008284|positive regulation of cell proliferation;GO:0008299|isoprenoid biosynthetic process;GO:0009410|response to xenobiotic stimulus;GO:0019287|isopentenyl diphosphate biosynthetic process, mevalonate pathway;","GO:0005777|peroxisome;GO:0005782|peroxisomal matrix;GO:0005829|cytosol;","GO:0004163|diphosphomevalonate decarboxylase activity;GO:0005524|ATP binding;GO:0030544|Hsp70 protein binding;GO:0042803|protein homodimerization activity;","K01597","MVD, mvaD; diphosphomevalonate decarboxylase [EC:4.1.1.33]"]
["ENSRNOG00000003901",2096,134.8365984,823,53.1344105,2.53765116,1.343493762,{"v":7.0646e-126,"d":"7.06E-126"},{"v":5.2197E-125,"d":"5.22E-125"},"up","yes","Cfap36","protein_coding","chr14:102966001-102991555:-","gi|67846002|ref|NP_001020037.1|",1371,{"v":2e-177,"d":"2.00E-177"},"cilia- and flagella-associated protein 36 [Rattus norvegicus]","gi|67846001|ref|NM_001024866.1|",1217,0,"Rattus norvegicus cilia and flagella associated protein 36 (Cfap36), mRNA","Q4V8E4",532,{"v":7e-179,"d":"7.00E-179"},"Cilia- and flagella-associated protein 36",".",".",".",".","pfam11527","ARL2_Bind_BART","The ARF-like 2 binding protein BART. BART binds specifically to ARL2.GTP with a high affinity however it does not bind to ARL2.GDP. It is thought that this specific interaction is due to BART being the first identified ARL2-specific effector. The function is not completely characterized. BART is predominantly cytosolic but can also be found to be associated with mitochondria. BART is also involved in binding to the adenine nucleotide transporter ANT1.",".","GO:0005634|nucleus;GO:0005930|axoneme;GO:0031514|motile cilium;GO:0035869|ciliary transition zone;GO:0097546|ciliary base;","GO:0047485|protein N-terminus binding;","K25395","CFAP36; cilia- and flagella-associated protein 36"]
["ENSRNOG00000051531",1126,72.4360734,271,17.49626397,4.140088052,2.049661451,{"v":2.9213e-123,"d":"2.92E-123"},{"v":2.1173E-122,"d":"2.12E-122"},"up","yes","Ctu2","protein_coding","chr19:50539352-50544623:+","gi|50926101|gb|AAH79393.1|",2630,0,"LOC292069 protein, partial [Rattus norvegicus]","gi|50926100|gb|BC079393.1|",1682,0,"Rattus norvegicus similar to RIKEN cDNA 2310061F22, mRNA (cDNA clone IMAGE:7111976), partial cds","Q3B7U4",976,0,"Cytoplasmic tRNA 2-thiolation protein 2",".",".",".",".","pfam10288","DUF2392","Protein of unknown function (DUF2392). This is a family of proteins conserved from plants to humans. The function is not known. It carries a characteristic GRG sequence motif.","GO:0002098|tRNA wobble uridine modification;GO:0002143|tRNA wobble position uridine thiolation;GO:0008150|biological_process;GO:0032447|protein urmylation;GO:0034227|tRNA thio-modification;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0032991|protein-containing complex;","GO:0000049|tRNA binding;GO:0003674|molecular_function;GO:0016779|nucleotidyltransferase activity;GO:0016783|sulfurtransferase activity;","K14169","CTU2, NCS2; cytoplasmic tRNA 2-thiolation protein 2"]
["ENSRNOG00000016356",2270,146.0300947,947,61.14008109,2.388451112,1.256075347,{"v":7.0542e-123,"d":"7.05E-123"},{"v":5.1063e-122,"d":"5.11E-122"},"up","yes","Got1","protein_coding","chr1:242357306-242380633:-","gi|401461792|ref|NP_036703.2|",2017,0,"aspartate aminotransferase, cytoplasmic [Rattus norvegicus]","gi|401461791|ref|NM_012571.2|",1621,0,"Rattus norvegicus glutamic-oxaloacetic transaminase 1, soluble (Got1), mRNA","P13221",781,0,"Aspartate aminotransferase, cytoplasmic","SPAC10F6.13c",362,{"v":2E-109,"d":"2.00E-109"},"COG1448","pfam00155","Aminotran_1_2","Aminotransferase class I and II.","GO:0006103|2-oxoglutarate metabolic process;GO:0006107|oxaloacetate metabolic process;GO:0006114|glycerol biosynthetic process;GO:0006531|aspartate metabolic process;GO:0006532|aspartate biosynthetic process;GO:0006533|aspartate catabolic process;GO:0006536|glutamate metabolic process;GO:0007219|Notch signaling pathway;GO:0009743|response to carbohydrate;GO:0019550|glutamate catabolic process to aspartate;GO:0019551|glutamate catabolic process to 2-oxoglutarate;GO:0030511|positive regulation of transforming growth factor beta receptor signaling pathway;GO:0032869|cellular response to insulin stimulus;GO:0032966|negative regulation of collagen biosynthetic process;GO:0035902|response to immobilization stress;GO:0043648|dicarboxylic acid metabolic process;GO:0046686|response to cadmium ion;GO:0051384|response to glucocorticoid;GO:0051481|negative regulation of cytosolic calcium ion concentration;GO:0051902|negative regulation of mitochondrial depolarization;GO:0055089|fatty acid homeostasis;GO:0060290|transdifferentiation;GO:0071260|cellular response to mechanical stimulus;GO:1990267|response to transition metal nanoparticle;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0005829|cytosol;GO:0043679|axon terminus;","GO:0004069|L-aspartate:2-oxoglutarate aminotransferase activity;GO:0004609|phosphatidylserine decarboxylase activity;GO:0030170|pyridoxal phosphate binding;GO:0031406|carboxylic acid binding;GO:0047801|L-cysteine:2-oxoglutarate aminotransferase activity;","K14454","GOT1; aspartate aminotransferase, cytoplasmic [EC:2.6.1.1]"]
["ENSRNOG00000011057",3186,204.9567761,1570,101.3621197,2.022025356,1.015801088,{"v":1.3447e-122,"d":"1.34E-122"},{"v":9.7095e-122,"d":"9.71E-122"},"up","yes","Mfn1","protein_coding","chr2:115313401-115359640:+","gi|672042036|ref|XP_008759126.1|",3299,0,"PREDICTED: LOW QUALITY PROTEIN: mitofusin-1 isoform X1 [Rattus norvegicus]","gi|672042035|ref|XM_008760904.1|",3979,0,"PREDICTED: Rattus norvegicus mitofusin 1 (Mfn1), transcript variant X1, mRNA","Q8R4Z9",1268,0,"Mitofusin-1","all3927",59.7,7e-08,"COG0699","pfam04799","Fzo_mitofusin","fzo-like conserved region. Family of putative transmembrane GTPase. The fzo protein is a mediator of mitochondrial fusion. This conserved region is also found in the human mitofusin protein.","GO:0008053|mitochondrial fusion;GO:0008584|male gonad development;GO:0010042|response to manganese ion;GO:0010636|positive regulation of mitochondrial fusion;GO:0010918|positive regulation of mitochondrial membrane potential;GO:0014850|response to muscle activity;GO:0031667|response to nutrient levels;GO:0045471|response to ethanol;GO:0046039|GTP metabolic process;GO:0048312|intracellular distribution of mitochondria;GO:0051412|response to corticosterone;GO:0051592|response to calcium ion;GO:0051602|response to electrical stimulus;GO:0051646|mitochondrion localization;GO:0061003|positive regulation of dendritic spine morphogenesis;GO:0070584|mitochondrion morphogenesis;GO:0071333|cellular response to glucose stimulus;GO:0071456|cellular response to hypoxia;GO:0071549|cellular response to dexamethasone stimulus;GO:0090258|negative regulation of mitochondrial fission;GO:0090650|cellular response to oxygen-glucose deprivation;GO:1902617|response to fluoride;GO:1905395|response to flavonoid;GO:1990613|mitochondrial membrane fusion;GO:1990910|response to hypobaric hypoxia;","GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0005743|mitochondrial inner membrane;GO:0016021|integral component of membrane;GO:0031306|intrinsic component of mitochondrial outer membrane;GO:0031307|integral component of mitochondrial outer membrane;GO:0098799|outer mitochondrial membrane protein complex;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0042802|identical protein binding;","K21356","MFN1; mitofusin 1 [EC:3.6.5.-]"]
["ENSRNOG00000011039",1213,78.03282152,320,20.65979509,3.777037535,1.917255121,{"v":1.1507E-121,"d":"1.15E-121"},{"v":8.2774e-121,"d":"8.28E-121"},"up","yes","Gch1","protein_coding","chr15:20402527-20437698:-","gi|13242245|ref|NP_077332.1|",1290,{"v":2e-168,"d":"2.00E-168"},"GTP cyclohydrolase 1 precursor [Rattus norvegicus]","gi|13542897|gb|BC005643.1|",1365,0,"Mus musculus GTP cyclohydrolase 1, mRNA (cDNA clone MGC:12095 IMAGE:3709238), complete cds","P22288",501,{"v":5e-170,"d":"5.00E-170"},"GTP cyclohydrolase 1","alr5287",260,{"v":7e-79,"d":"7.00E-79"},"COG0302","pfam01227","GTP_cyclohydroI","GTP cyclohydrolase I. This family includes GTP cyclohydrolase enzymes and a family of related bacterial proteins.","GO:0006729|tetrahydrobiopterin biosynthetic process;GO:0008217|regulation of blood pressure;GO:0010460|positive regulation of heart rate;GO:0014916|regulation of lung blood pressure;GO:0032496|response to lipopolysaccharide;GO:0034341|response to interferon-gamma;GO:0034612|response to tumor necrosis factor;GO:0035998|7,8-dihydroneopterin 3'-triphosphate biosynthetic process;GO:0042311|vasodilation;GO:0042416|dopamine biosynthetic process;GO:0042559|pteridine-containing compound biosynthetic process;GO:0045776|negative regulation of blood pressure;GO:0046654|tetrahydrofolate biosynthetic process;GO:0048265|response to pain;GO:0050884|neuromuscular process controlling posture;GO:0051000|positive regulation of nitric-oxide synthase activity;GO:0051066|dihydrobiopterin metabolic process;GO:0065003|protein-containing complex assembly;GO:2000121|regulation of removal of superoxide radicals;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0031410|cytoplasmic vesicle;GO:0031965|nuclear membrane;GO:0032991|protein-containing complex;","GO:0003924|GTPase activity;GO:0003934|GTP cyclohydrolase I activity;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0005525|GTP binding;GO:0008270|zinc ion binding;GO:0030742|GTP-dependent protein binding;GO:0031369|translation initiation factor binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0044877|protein-containing complex binding;GO:0051019|mitogen-activated protein kinase binding;","K01495","GCH1, folE; GTP cyclohydrolase IA [EC:3.5.4.16]"]
["ENSRNOG00000011905",3137,201.8045846,1541,99.48982573,2.028394191,1.020338048,{"v":1.2853e-121,"d":"1.29E-121"},{"v":9.234e-121,"d":"9.23E-121"},"up","yes","Atp6v1e1","protein_coding","chr4:154022358-154044584:-","gi|148667229|gb|EDK99645.1|",622,{"v":2e-72,"d":"2.00E-72"},"VATPase, H+ transporting, lysosomal V1 subunit E1, isoform CRA_a, partial [Mus musculus]","gi|298900963|emb|FQ213667.1|",643,0,"Rattus norvegicus TL0AAA46YH14 mRNA sequence","P50518",227,{"v":5e-68,"d":"5.00E-68"},"V-type proton ATPase subunit E 1",".",".",".",".","pfam01991","vATP-synt_E","ATP synthase (E/31 kDa) subunit. This family includes the vacuolar ATP synthase E subunit, as well as the archaebacterial ATP synthase E subunit.","GO:1902600|proton transmembrane transport;","GO:0000221|vacuolar proton-transporting V-type ATPase, V1 domain;GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005829|cytosol;GO:0005902|microvillus;GO:0016324|apical plasma membrane;","GO:0016787|hydrolase activity;GO:0046961|proton-transporting ATPase activity, rotational mechanism;GO:0051117|ATPase binding;","K02150","ATPeV1E, ATP6E; V-type H+-transporting ATPase subunit E"]
["ENSRNOG00000055934",739,47.54019382,98,6.327062246,7.513786331,2.909540091,{"v":4.9061e-121,"d":"4.91E-121"},{"v":3.5113E-120,"d":"3.51E-120"},"up","yes","Dmkn","protein_coding","chr1:86014188-86030006:+","gi|290563809|ref|NP_001166828.1|",1739,0,"dermokine precursor [Rattus norvegicus]","gi|290563808|ref|NM_001173357.1|",1667,0,"Rattus norvegicus dermokine (Dmkn), mRNA","Q6P253",313,{"v":1E-97,"d":"1.00E-97"},"Dermokine",".",".",".",".","pfam04625","DEC-1_N","DEC-1 protein, N-terminal region. The defective chorion-1 gene (dec-1) in Drosophila encodes follicle cell proteins necessary for proper eggshell assembly. Multiple products of the dec-1 gene are formed by alternative RNA splicing and proteolytic processing. Cleavage products include S80 (80 kDa) which is incorporated into the eggshell, and further proteolysis of S80 gives S60 (60 kDa).","GO:1903575|cornified envelope assembly;","GO:0005615|extracellular space;",".",".","."]
["ENSRNOG00000011189",1823,117.2743888,673,43.45013155,2.699057164,1.432455532,{"v":9.2008e-121,"d":"9.20E-121"},{"v":6.5604e-120,"d":"6.56E-120"},"up","yes","Acy1","protein_coding","chr8:107072358-107077682:-","gi|564365356|ref|XP_006243777.1|",1952,0,"PREDICTED: aminoacylase-1A isoform X1 [Rattus norvegicus]","gi|672062871|ref|XM_006243716.2|",1233,0,"PREDICTED: Rattus norvegicus aminoacylase 1 (Acy1), transcript variant X2, mRNA","Q6AYS7",756,0,"Aminoacylase-1A","CC0736",97.1,{"v":2e-20,"d":"2.00E-20"},"COG0624","pfam01546","Peptidase_M20","Peptidase family M20/M25/M40. This family includes a range of zinc metallopeptidases belonging to several families in the peptidase classification. Family M20 are Glutamate carboxypeptidases. Peptidase family M25 contains X-His dipeptidases.","GO:0006520|cellular amino acid metabolic process;GO:0030163|protein catabolic process;","GO:0005737|cytoplasm;GO:0070062|extracellular exosome;","GO:0004046|aminoacylase activity;GO:0042802|identical protein binding;GO:0046872|metal ion binding;","K14677","ACY1; aminoacylase [EC:3.5.1.14]"]
["ENSRNOG00000017512",1084,69.73419499,256,16.52783607,4.219196917,2.076968422,{"v":9.7068e-121,"d":"9.71E-121"},{"v":6.9125e-120,"d":"6.91E-120"},"up","yes","Aldh3b1","protein_coding","chr1:201145309-201163921:-","gi|55742838|ref|NP_001006999.1|",2518,0,"aldehyde dehydrogenase family 3 member B1 [Rattus norvegicus]","gi|672039352|ref|XM_008760134.1|",1832,0,"PREDICTED: Rattus norvegicus aldehyde dehydrogenase 3 family, member B1 (Aldh3b1), transcript variant X4, mRNA","Q5XI42",974,0,"Aldehyde dehydrogenase family 3 member B1","alr3672",460,{"v":1e-154,"d":"1.00E-154"},"COG1012","pfam00171","Aldedh","Aldehyde dehydrogenase family. This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:1.2.1.3. Succinate-semialdehyde dehydrogenase EC:1.2.1.16. Lactaldehyde dehydrogenase EC:1.2.1.22. Benzaldehyde dehydrogenase EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase EC: 1.5.1.12. Acetaldehyde dehydrogenase EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase EC:1.2.1.41. This family also includes omega crystallin, an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.","GO:0006068|ethanol catabolic process;GO:0006081|cellular aldehyde metabolic process;GO:0006979|response to oxidative stress;GO:0034599|cellular response to oxidative stress;GO:0046185|aldehyde catabolic process;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0004029|aldehyde dehydrogenase (NAD) activity;GO:0004030|aldehyde dehydrogenase [NAD(P)+] activity;GO:0016620|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor;GO:0018477|benzaldehyde dehydrogenase (NADP+) activity;GO:0018479|benzaldehyde dehydrogenase (NAD+) activity;","K00129","ALDH3; aldehyde dehydrogenase (NAD(P)+) [EC:1.2.1.5]"]
["ENSRNOG00000008943",1099,70.69915157,267,17.23801653,4.101350724,2.03609912,{"v":2.4257E-119,"d":"2.43E-119"},{"v":1.7125e-118,"d":"1.71E-118"},"up","yes","Penk","protein_coding","chr5:17183806-17189129:-","gi|564350204|ref|XP_006237897.1|",1433,0,"PREDICTED: proenkephalin-A isoform X1 [Rattus norvegicus]","gi|564350203|ref|XM_006237835.1|",1282,0,"PREDICTED: Rattus norvegicus proenkephalin (Penk), transcript variant X1, mRNA","P04094",556,0,"Proenkephalin-A",".",".",".",".","pfam01160","Opiods_neuropep","Vertebrate endogenous opioids neuropeptide.","GO:0001649|osteoblast differentiation;GO:0001662|behavioral fear response;GO:0001666|response to hypoxia;GO:0001964|startle response;GO:0002118|aggressive behavior;GO:0007218|neuropeptide signaling pathway;GO:0007268|chemical synaptic transmission;GO:0007568|aging;GO:0007600|sensory perception;GO:0007626|locomotory behavior;GO:0009314|response to radiation;GO:0009617|response to bacterium;GO:0009636|response to toxic substance;GO:0014009|glial cell proliferation;GO:0019233|sensory perception of pain;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0034599|cellular response to oxidative stress;GO:0035094|response to nicotine;GO:0035641|locomotory exploration behavior;GO:0043278|response to morphine;GO:0045471|response to ethanol;GO:0051592|response to calcium ion;GO:0051867|general adaptation syndrome, behavioral process;GO:0071305|cellular response to vitamin D;GO:0071320|cellular response to cAMP;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0071871|response to epinephrine;GO:0098586|cellular response to virus;GO:0099538|synaptic signaling via neuropeptide;GO:2000987|positive regulation of behavioral fear response;","GO:0005576|extracellular region;GO:0005886|plasma membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0032280|symmetric synapse;GO:0034466|chromaffin granule lumen;GO:0034592|synaptic vesicle lumen;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0043679|axon terminus;GO:0070852|cell body fiber;GO:0099013|neuronal dense core vesicle lumen;","GO:0001515|opioid peptide activity;GO:0003674|molecular_function;GO:0031628|opioid receptor binding;","K18832","PENK; proenkephalin A"]
["ENSRNOG00000009754",2365,152.1414863,1026,66.24046801,2.296805727,1.199628833,{"v":3.8448e-119,"d":"3.84E-119"},{"v":2.711e-118,"d":"2.71E-118"},"up","yes","Nampt","protein_coding","chr6:49424332-49462100:+","gi|29293813|ref|NP_808789.1|",2456,0,"nicotinamide phosphoribosyltransferase [Rattus norvegicus]","gi|257153453|ref|NM_021524.2|",2981,0,"Mus musculus nicotinamide phosphoribosyltransferase (Nampt), mRNA","Q80Z29",949,0,"Nicotinamide phosphoribosyltransferase","RSp0836",377,{"v":3e-115,"d":"3.00E-115"},"COG1488","pfam04095","NAPRTase","Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyses the first reaction in the NAD salvage synthesis. This family also includes Pre-B cell enhancing factor that is a cytokine. This family is related to Quinolinate phosphoribosyltransferase pfam01729.","GO:0001774|microglial cell activation;GO:0007165|signal transduction;GO:0007565|female pregnancy;GO:0007568|aging;GO:0007623|circadian rhythm;GO:0009435|NAD biosynthetic process;GO:0010507|negative regulation of autophagy;GO:0014070|response to organic cyclic compound;GO:0014916|regulation of lung blood pressure;GO:0032922|circadian regulation of gene expression;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0051770|positive regulation of nitric-oxide synthase biosynthetic process;GO:0070997|neuron death;GO:0071479|cellular response to ionizing radiation;GO:0090650|cellular response to oxygen-glucose deprivation;GO:1904646|cellular response to amyloid-beta;GO:1905377|response to D-galactose;GO:2000773|negative regulation of cellular senescence;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016607|nuclear speck;GO:0030054|cell junction;","GO:0000166|nucleotide binding;GO:0004514|nicotinate-nucleotide diphosphorylase (carboxylating) activity;GO:0005125|cytokine activity;GO:0042802|identical protein binding;GO:0047280|nicotinamide phosphoribosyltransferase activity;GO:1901363|heterocyclic compound binding;","K03462","NAMPT; nicotinamide phosphoribosyltransferase [EC:2.4.2.12]"]
["ENSRNOG00000045931",2802,180.2538878,1322,85.35077846,2.111918497,1.07855416,{"v":5.373e-119,"d":"5.37E-119"},{"v":3.7792e-118,"d":"3.78E-118"},"up","yes","Sik3","protein_coding","chr8:46311989-46522444:+","gi|685844844|ref|NP_001258145.2|",6584,0,"serine/threonine-protein kinase SIK3 [Rattus norvegicus]","gi|685844843|ref|NM_001271216.2|",6248,0,"Rattus norvegicus SIK family kinase 3 (Sik3), mRNA","Q6P4S6",2416,0,"Serine/threonine-protein kinase SIK3",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0000226|microtubule cytoskeleton organization;GO:0001958|endochondral ossification;GO:0006468|protein phosphorylation;GO:0032880|regulation of protein localization;GO:0035108|limb morphogenesis;GO:0035264|multicellular organism growth;GO:0035556|intracellular signal transduction;GO:0048705|skeletal system morphogenesis;GO:0060351|cartilage development involved in endochondral bone morphogenesis;GO:1904263|positive regulation of TORC1 signaling;GO:1904515|positive regulation of TORC2 signaling;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;","GO:0000287|magnesium ion binding;GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;GO:0050321|tau-protein kinase activity;","K19009","SIK3; serine/threonine-protein kinase SIK3 [EC:2.7.11.1]"]
["ENSRNOG00000047581",553,35.57473232,2,0.129123719,275.508888,8.105955051,{"v":3.5653e-116,"d":"3.57E-116"},{"v":2.4533E-115,"d":"2.45E-115"},"up","yes","AABR07066700.1","protein_coding","chr9:2849456-2916360:-","gi|672033554|ref|XP_008756458.1|",724,{"v":9e-112,"d":"9.00E-112"},"PREDICTED: uncharacterized protein LOC102557335 [Rattus norvegicus]","gi|672033553|ref|XM_008758236.1|",1256,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102557335 (LOC102557335), mRNA",".",".",".",".",".",".",".",".","pfam04822","Takusan","Takusan. This domain is named takusan, which is a Japanese word meaning 'many'. Members of this family regulate synaptic activity.",".",".",".",".","."]
["ENSRNOG00000069240",946,60.85659452,201,12.97693379,4.689597366,2.229464063,{"v":2.9967e-115,"d":"3.00E-115"},{"v":2.04e-114,"d":"2.04E-114"},"up","yes","ENSRNOG00000069240","protein_coding","chr11:12193771-12199421:-","gi|852749799|ref|XP_012872059.1|",906,{"v":1E-108,"d":"1.00E-108"},"PREDICTED: endogenous retrovirus group K member 8 Pol protein-like [Dipodomys ordii]","gi|153791782|ref|NG_006339.2|",1903,0,"Rattus norvegicus vomeronasal 2 receptor, pseudogene 55 (Vom2r-ps55) on chromosome 1","P04026",299,{"v":3e-91,"d":"3.00E-91"},"Intracisternal A-particle Pol-related polyprotein (Fragment)",".",".",".",".","pfam00665","rve","Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyses the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.",".",".",".",".","."]
["ENSRNOG00000022101",2781,178.9029486,1332,85.99639706,2.080354,1.056829043,{"v":2.4917e-114,"d":"2.49E-114"},{"v":1.6841e-113,"d":"1.68E-113"},"up","yes","Crabp2","protein_coding","chr2:173416857-173421379:+","gi|672015943|ref|XP_008773398.1|",674,{"v":1E-83,"d":"1.00E-83"},"PREDICTED: cellular retinoic acid-binding protein 2 isoform X1 [Rattus norvegicus]","gi|672015942|ref|XM_008775176.1|",913,0,"PREDICTED: Rattus norvegicus cellular retinoic acid-binding protein 2-like (LOC100911902), transcript variant X1, mRNA","P51673",237,{"v":1e-74,"d":"1.00E-74"},"Cellular retinoic acid-binding protein 2",".",".",".",".","pfam00061","Lipocalin","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.","GO:0002138|retinoic acid biosynthetic process;GO:0006869|lipid transport;GO:0035115|embryonic forelimb morphogenesis;GO:0042573|retinoic acid metabolic process;GO:0048672|positive regulation of collateral sprouting;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;","GO:0001972|retinoic acid binding;GO:0008289|lipid binding;GO:0016918|retinal binding;GO:0019841|retinol binding;GO:0030332|cyclin binding;","K17289","CRABP2; cellular retinoic acid-binding protein 2"]
["ENSRNOG00000007304",1554,99.96950094,535,34.54059492,2.89426112,1.533195088,{"v":5.3775E-114,"d":"5.38E-114"},{"v":3.626e-113,"d":"3.63E-113"},"up","yes","Herc3","protein_coding","chr4:87952274-88042488:+","gi|157820833|ref|NP_001102101.1|",5588,0,"probable E3 ubiquitin-protein ligase HERC3 [Rattus norvegicus]","gi|157820832|ref|NM_001108631.1|",5227,0,"Rattus norvegicus HECT and RLD domain containing E3 ubiquitin protein ligase 3 (Herc3), mRNA","Q15034",2085,0,"Probable E3 ubiquitin-protein ligase HERC3","SPBP8B7.27",255,{"v":1e-69,"d":"1.00E-69"},"COG5021","pfam00632","HECT","HECT-domain (ubiquitin-transferase). The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.","GO:0016567|protein ubiquitination;","GO:0005829|cytosol;","GO:0004842|ubiquitin-protein transferase activity;","K10614","HERC3; E3 ubiquitin-protein ligase HERC3 [EC:2.3.2.26]"]
["ENSRNOG00000064647",2323,149.4396079,1023,66.04678243,2.262632674,1.17800239,{"v":8.7732e-114,"d":"8.77E-114"},{"v":5.9088e-113,"d":"5.91E-113"},"up","yes","Echs1","protein_coding","chr1:194895036-194903884:-","gi|17530977|ref|NP_511178.1|",1484,0,"enoyl-CoA hydratase, mitochondrial precursor [Rattus norvegicus]","gi|564329043|ref|XM_003748886.2|",1483,0,"PREDICTED: Rattus norvegicus enoyl-CoA hydratase, mitochondrial-like (LOC100911186), mRNA","P14604",576,0,"Enoyl-CoA hydratase, mitochondrial","BMEI1945",306,{"v":3e-99,"d":"3.00E-99"},"COG1024","pfam00378","ECH","Enoyl-CoA hydratase/isomerase family. This family contains a diverse set of enzymes including: Enoyl-CoA hydratase. Napthoate synthase. Carnitate racemase. 3-hydoxybutyryl-CoA dehydratase. Dodecanoyl-CoA delta-isomerase.",".",".",".",".","."]
["ENSRNOG00000029543",860,55.32417684,164,10.58814498,5.225105713,2.385460226,{"v":1.1604E-113,"d":"1.16E-113"},{"v":7.8058e-113,"d":"7.81E-113"},"up","yes","Cish","protein_coding","chr8:107972306-107977250:+","gi|198278490|ref|NP_113992.1|",1202,{"v":5e-159,"d":"5.00E-159"},"cytokine-inducible SH2-containing protein [Rattus norvegicus]","gi|198278489|ref|NM_031804.1|",1854,0,"Rattus norvegicus cytokine inducible SH2-containing protein (Cish), mRNA","O70512",465,{"v":9e-160,"d":"9.00E-160"},"Cytokine-inducible SH2-containing protein (Fragment)",".",".",".",".","pfam00017","SH2","SH2 domain.","GO:0007205|protein kinase C-activating G protein-coupled receptor signaling pathway;GO:0009968|negative regulation of signal transduction;GO:0016567|protein ubiquitination;GO:0019221|cytokine-mediated signaling pathway;GO:0035556|intracellular signal transduction;GO:0040008|regulation of growth;GO:0043551|regulation of phosphatidylinositol 3-kinase activity;GO:0046854|phosphatidylinositol phosphorylation;","GO:0005886|plasma membrane;GO:0005942|phosphatidylinositol 3-kinase complex;","GO:0046935|1-phosphatidylinositol-3-kinase regulator activity;","K04701","CISH; cytokine inducible SH2-containing protein"]
["ENSRNOG00000065022",665,42.77974139,81,5.229510632,8.180448306,3.032179908,{"v":1.711e-113,"d":"1.71E-113"},{"v":1.147E-112,"d":"1.15E-112"},"up","yes","RGD1560394","protein_coding","chr14:76768146-76773575:-","gi|564384243|ref|XP_006251255.1|",472,{"v":1E-50,"d":"1.00E-50"},"PREDICTED: neuropeptide-like protein C4orf48 homolog isoform X1 [Rattus norvegicus]","gi|672076586|ref|XM_006251193.2|",509,0,"PREDICTED: Rattus norvegicus RGD1560394 (RGD1560394), transcript variant X1, mRNA","Q3UR78",126,{"v":6e-32,"d":"6.00E-32"},"Neuropeptide-like protein C4orf48 homolog",".",".",".",".","pfam15161","Neuropep_like","Neuropeptide-like. This family contains putative neuropeptides.",".",".",".",".","."]
["ENSRNOG00000003242",1831,117.7890323,706,45.58067292,2.584188095,1.369711083,{"v":1.8515E-113,"d":"1.85E-113"},{"v":1.2397e-112,"d":"1.24E-112"},"up","yes","Gulp1","protein_coding","chr9:46622669-46899005:+","gi|61557172|ref|NP_001013189.1|",1454,0,"PTB domain-containing engulfment adapter protein 1 [Rattus norvegicus]","gi|672064875|ref|XM_006244804.2|",2627,0,"PREDICTED: Rattus norvegicus GULP, engulfment adaptor PTB domain containing 1 (Gulp1), transcript variant X2, mRNA","Q5PQS4",564,0,"PTB domain-containing engulfment adapter protein 1",".",".",".",".","pfam00640","PID","Phosphotyrosine interaction domain (PTB/PID).","GO:0006869|lipid transport;GO:0006911|phagocytosis, engulfment;GO:0006915|apoptotic process;","GO:0005737|cytoplasm;",".","K23285","GULP1, CED6; PTB domain-containing engulfment adapter protein 1"]
["ENSRNOG00000024967",2369,152.3988081,1058,68.30644752,2.23110429,1.157757952,{"v":6.8997e-113,"d":"6.90E-113"},{"v":4.5982e-112,"d":"4.60E-112"},"up","yes","Uqcrb","protein_coding","chr7:63814797-63820150:-","gi|537109201|gb|ERE60466.1|",500,{"v":7e-57,"d":"7.00E-57"},"cytochrome b-c1 complex subunit 7-like protein [Cricetulus griseus]","gi|198278431|ref|NM_001127553.2|",989,0,"Rattus norvegicus ubiquinol-cytochrome c reductase binding protein (Uqcrb), mRNA","Q9D855",189,{"v":2E-55,"d":"2.00E-55"},"Cytochrome b-c1 complex subunit 7",".",".",".",".","pfam02271","UCR_14kD","Ubiquinol-cytochrome C reductase complex 14kD subunit. The ubiquinol-cytochrome C reductase complex (cytochrome bc1 complex) is a respiratory multienzyme complex. This Pfam family represents the 14kD (or VI) subunit of the complex which is not directly involved in electron transfer, but has a role in assembly of the complex.","GO:0006122|mitochondrial electron transport, ubiquinol to cytochrome c;","GO:0005739|mitochondrion;GO:0005750|mitochondrial respiratory chain complex III;","GO:0044877|protein-containing complex binding;","K00417","QCR7, UQCRB; ubiquinol-cytochrome c reductase subunit 7"]
["ENSRNOG00000043143",2187,140.6906683,939,60.62358622,2.320724937,1.214575538,{"v":1.8269e-112,"d":"1.83E-112"},{"v":1.2119e-111,"d":"1.21E-111"},"up","yes","Eml1","protein_coding","chr6:127284029-127457246:+","gi|913486881|ref|XP_005343594.2|",4032,0,"PREDICTED: echinoderm microtubule-associated protein-like 1 isoform X1 [Microtus ochrogaster]","gi|556503434|ref|NM_001286347.1|",2760,0,"Mus musculus echinoderm microtubule associated protein like 1 (Eml1), transcript variant 4, mRNA","Q4V8C3",1520,0,"Echinoderm microtubule-associated protein-like 1","all0284_3",83.2,{"v":3e-15,"d":"3.00E-15"},"COG2319","pfam03451","HELP","HELP motif. The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.","GO:0000226|microtubule cytoskeleton organization;GO:0002244|hematopoietic progenitor cell differentiation;GO:0007052|mitotic spindle organization;GO:0007405|neuroblast proliferation;GO:0007420|brain development;","GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0005874|microtubule;GO:0015630|microtubule cytoskeleton;GO:0048471|perinuclear region of cytoplasm;GO:0072686|mitotic spindle;GO:0097431|mitotic spindle pole;GO:1990023|mitotic spindle midzone;","GO:0008017|microtubule binding;GO:0015631|tubulin binding;","K18595","EML1_2; echinoderm microtubule-associated protein-like 1/2"]
["ENSRNOG00000069713",893,57.4470813,182,11.75025846,4.889005762,2.289541106,{"v":2.0262e-112,"d":"2.03E-112"},{"v":1.3409E-111,"d":"1.34E-111"},"up","yes","ENSRNOG00000069713","lncRNA","chrX:15395785-15398610:-","gi|149061698|gb|EDM12121.1|",421,{"v":5e-45,"d":"5.00E-45"},"rCG47580, partial [Rattus norvegicus]","gi|228480382|gb|AC122990.5|",1389,0,"Rattus norvegicus CH230-360O12 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P10273",129,{"v":1e-40,"d":"1.00E-40"},"Gag-Pol polyprotein",".",".",".",".","pfam00429","TLV_coat","ENV polyprotein (coat polyprotein).",".",".",".",".","."]
["ENSRNOG00000047158",2077,133.6143201,874,56.42706534,2.367911911,1.243615412,{"v":6.9783e-111,"d":"6.98E-111"},{"v":4.5497e-110,"d":"4.55E-110"},"up","yes","Selenbp1","protein_coding","chr2:182493978-182504594:+","gi|18266692|ref|NP_543168.1|",2528,0,"selenium-binding protein 1 [Rattus norvegicus]","gi|672043348|ref|XM_008761279.1|",1620,0,"PREDICTED: Rattus norvegicus selenium-binding protein 1 (LOC103689947), transcript variant X2, mRNA","Q8VIF7",978,0,"Methanethiol oxidase",".",".",".",".","pfam05694","SBP56","56kDa selenium binding protein (SBP56). This family consists of several eukaryotic selenium binding proteins as well as three sequences from archaea. The exact function of this protein is unknown although it is thought that SBP56 participates in late stages of intra-Golgi protein transport. The Lotus japonicus homologue of SBP56, LjSBP is thought to have more than one physiological role and can be implicated in controlling the oxidation/reduction status of target proteins, in vesicular Golgi transport.","GO:0015031|protein transport;","GO:0005634|nucleus;GO:0005829|cytosol;GO:0016020|membrane;","GO:0008430|selenium binding;GO:0018549|methanethiol oxidase activity;","K17285","SELENBP1; methanethiol oxidase [EC:1.8.3.4]"]
["ENSRNOG00000042607",881,56.67511604,180,11.62113474,4.876900347,2.285964493,{"v":9.9202e-111,"d":"9.92E-111"},{"v":6.4457e-110,"d":"6.45E-110"},"up","yes","Rhof","protein_coding","chr12:33431280-33446703:+","gi|392332607|ref|XP_003752637.1|",960,{"v":6e-122,"d":"6.00E-122"},"PREDICTED: rho-related GTP-binding protein RhoF [Rattus norvegicus]","gi|672073135|ref|XM_001073389.5|",2161,0,"PREDICTED: Rattus norvegicus ras homolog family member F (in filopodia) (Rhof), transcript variant X2, mRNA","Q8BYP3",367,{"v":5e-121,"d":"5.00E-121"},"Rho-related GTP-binding protein RhoF",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0007015|actin filament organization;GO:0007163|establishment or maintenance of cell polarity;GO:0007264|small GTPase mediated signal transduction;GO:0008360|regulation of cell shape;GO:0016477|cell migration;GO:0030865|cortical cytoskeleton organization;GO:0032956|regulation of actin cytoskeleton organization;","GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0005938|cell cortex;GO:0031410|cytoplasmic vesicle;GO:0042995|cell projection;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0019901|protein kinase binding;","K07872","RHOF, RIF; Ras homolog gene family, member F"]
["ENSRNOG00000009063",1588,102.1567358,568,36.67113628,2.785753216,1.478067458,{"v":2.0492e-110,"d":"2.05E-110"},{"v":1.3285e-109,"d":"1.33E-109"},"up","yes","Dnajc15","protein_coding","chr15:53184855-53249675:-","gi|157823235|ref|NP_001099520.1|",545,{"v":2e-65,"d":"2.00E-65"},"dnaJ homolog subfamily C member 15 [Rattus norvegicus]","gi|157823234|ref|NM_001106050.1|",537,0,"Rattus norvegicus DnaJ heat shock protein family (Hsp40) member C15 (Dnajc15), mRNA","Q78YY6",209,{"v":7e-65,"d":"7.00E-65"},"DnaJ homolog subfamily C member 15","SPAC824.06",53.5,7e-08,"COG2214","pfam00226","DnaJ","DnaJ domain. DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.","GO:0009267|cellular response to starvation;GO:0019216|regulation of lipid metabolic process;GO:0030150|protein import into mitochondrial matrix;GO:0031333|negative regulation of protein complex assembly;GO:0050790|regulation of catalytic activity;GO:1902957|negative regulation of mitochondrial electron transport, NADH to ubiquinone;","GO:0001405|PAM complex, Tim23 associated import motor;GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;","GO:0001671|ATPase activator activity;","K09535","DNAJC15; DnaJ homolog subfamily C member 15"]
["ENSRNOG00000010064",1368,88.00403944,439,28.34265639,3.105003223,1.634594766,{"v":3.4312e-110,"d":"3.43E-110"},{"v":2.2168E-109,"d":"2.22E-109"},"up","yes","Abcc4","protein_coding","chr15:95542315-95774283:-","gi|45862334|gb|AAS78929.1|",6554,0,"multidrug resistance-associated protein 4 splice variant [Rattus norvegicus]","gi|45862333|gb|AY533525.1|",4359,0,"Rattus norvegicus multidrug resistance-associated protein 4 splice variant (Abcc4) mRNA, complete cds, alternatively spliced","O15439",2202,0,"Multidrug resistance-associated protein 4","YDR135c",776,0,"COG1132","pfam00664","ABC_membrane","ABC transporter transmembrane region. This family represents a unit of six transmembrane helices. Many members of the ABC transporter family (pfam00005) have two such regions.","GO:0009410|response to xenobiotic stimulus;GO:0010033|response to organic substance;GO:0010243|response to organonitrogen compound;GO:0014070|response to organic cyclic compound;GO:0015721|bile acid and bile salt transport;GO:0015732|prostaglandin transport;GO:0015747|urate transport;GO:0032310|prostaglandin secretion;GO:0034775|glutathione transmembrane transport;GO:0038183|bile acid signaling pathway;GO:0042908|xenobiotic transport;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0055085|transmembrane transport;GO:0060271|cilium assembly;GO:0070730|cAMP transport;GO:0071716|leukotriene transport;GO:0140115|export across plasma membrane;GO:1903790|guanine nucleotide transmembrane transport;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0031088|platelet dense granule membrane;GO:0098591|external side of apical plasma membrane;","GO:0001409|guanine nucleotide transmembrane transporter activity;GO:0003674|molecular_function;GO:0005524|ATP binding;GO:0008559|xenobiotic transmembrane transporting ATPase activity;GO:0015132|prostaglandin transmembrane transporter activity;GO:0015143|urate transmembrane transporter activity;GO:0015216|purine nucleotide transmembrane transporter activity;GO:0015431|glutathione S-conjugate-exporting ATPase activity;GO:0015432|bile acid-exporting ATPase activity;GO:0015562|efflux transmembrane transporter activity;GO:0034634|glutathione transmembrane transporter activity;GO:0042626|ATPase activity, coupled to transmembrane movement of substances;GO:0042910|xenobiotic transmembrane transporter activity;","K05673","ABCC4; ATP-binding cassette, subfamily C (CFTR/MRP), member 4"]
["ENSRNOG00000008271",2298,147.8313469,1024,66.11134429,2.236096521,1.160982463,{"v":4.8346e-110,"d":"4.83E-110"},{"v":3.1165e-109,"d":"3.12E-109"},"up","yes","Fam91a1","protein_coding","chr7:89969605-90007556:+","gi|564360175|ref|XP_006241746.1|",4086,0,"PREDICTED: protein FAM91A1 isoform X1 [Rattus norvegicus]","gi|672059234|ref|XM_006241684.2|",2685,0,"PREDICTED: Rattus norvegicus family with sequence similarity 91, member A1 (Fam91a1), transcript variant X1, mRNA","Q3UVG3",1543,0,"Protein FAM91A1",".",".",".",".","pfam14648","FAM91_C","FAM91 C-terminus.","GO:0006886|intracellular protein transport;GO:0099041|vesicle tethering to Golgi;","GO:0005802|trans-Golgi network;GO:0031410|cytoplasmic vesicle;",".",".","."]
["ENSRNOG00000001275",984,63.30115117,233,15.0429133,4.208038025,2.073147741,{"v":1.5786E-109,"d":"1.58E-109"},{"v":1.0119e-108,"d":"1.01E-108"},"up","yes","Tmem184a","protein_coding","chr12:14822898-14832065:+","gi|564378401|ref|XP_006249000.1|",2016,0,"PREDICTED: transmembrane protein 184A isoform X2 [Rattus norvegicus]","gi|672072001|ref|XM_006248938.2|",2022,0,"PREDICTED: Rattus norvegicus transmembrane protein 184A (Tmem184a), transcript variant X1, mRNA","Q4QQS1",733,0,"Transmembrane protein 184A",".",".",".",".","pfam03619","Solute_trans_a","Organic solute transporter Ostalpha. This family is a transmembrane organic solute transport protein. In vertebrates these proteins form a complex with Ostbeta, and function as bile transporters. In plants they may transport brassinosteroid-like compounds and act as regulators of cell death.","GO:0006810|transport;GO:0018992|germ-line sex determination;GO:0032880|regulation of protein localization;GO:0051046|regulation of secretion;","GO:0005768|endosome;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030658|transport vesicle membrane;GO:0030659|cytoplasmic vesicle membrane;GO:0030667|secretory granule membrane;GO:0031901|early endosome membrane;GO:0048471|perinuclear region of cytoplasm;","GO:0005215|transporter activity;GO:0008201|heparin binding;",".","."]
["ENSRNOG00000065000",1295,83.30791745,402,25.95386758,3.209845977,1.682504072,{"v":1.0115e-108,"d":"1.01E-108"},{"v":6.4475e-108,"d":"6.45E-108"},"up","yes","Lrrc8c","protein_coding","chr14:4227832-4315249:-","gi|81295329|ref|NP_001032256.1|",4108,0,"volume-regulated anion channel subunit LRRC8C [Rattus norvegicus]","gi|81295328|ref|NM_001037179.1|",2855,0,"Rattus norvegicus leucine rich repeat containing 8 family, member C (Lrrc8c), mRNA","Q498T9",1588,0,"Volume-regulated anion channel subunit LRRC8C","alr0124_1",122,{"v":3E-28,"d":"3.00E-28"},"COG4886","pfam12534","DUF3733","Leucine-rich repeat containing protein 8. This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00560. There are two completely conserved residues (W and Y) that may be functionally important. Many of the proteins in this family are annotated as leucine-rich repeat containing protein 8 however there is little accompanying literature to back this up.",".",".",".",".","."]
["ENSRNOG00000012879",1884,121.1985455,759,49.00245148,2.473315964,1.306446555,{"v":1.2002E-108,"d":"1.20E-108"},{"v":7.6416e-108,"d":"7.64E-108"},"up","yes","Fabp3","protein_coding","chr5:142651956-142658718:+","gi|6601500|gb|AAF19003.1|AF144090_1",601,{"v":4e-74,"d":"4.00E-74"},"fatty acid-binding protein [Rattus norvegicus]","gi|24182473|gb|AF144090.2|",754,0,"Rattus norvegicus heart fatty acid-binding protein (FABP) gene, complete cds","P07483",235,{"v":2e-75,"d":"2.00E-75"},"Fatty acid-binding protein, heart",".",".",".",".","pfam00061","Lipocalin","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.","GO:0006631|fatty acid metabolic process;GO:0006635|fatty acid beta-oxidation;GO:0009410|response to xenobiotic stimulus;GO:0015909|long-chain fatty acid transport;GO:0032365|intracellular lipid transport;GO:0032868|response to insulin;GO:0042632|cholesterol homeostasis;GO:0046320|regulation of fatty acid oxidation;GO:0050873|brown fat cell differentiation;GO:0055091|phospholipid homeostasis;GO:0070542|response to fatty acid;GO:0140214|positive regulation of long-chain fatty acid import into cell;GO:2001245|regulation of phosphatidylcholine biosynthetic process;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016528|sarcoplasm;","GO:0005324|long-chain fatty acid transporter activity;GO:0005504|fatty acid binding;GO:0008092|cytoskeletal protein binding;GO:0036041|long-chain fatty acid binding;GO:0050543|icosatetraenoic acid binding;GO:0070538|oleic acid binding;","K08752","FABP3; fatty acid-binding protein 3, muscle and heart"]
["ENSRNOG00000030447",937,60.27762058,213,13.75167611,4.383292634,2.132014998,{"v":4.2129e-108,"d":"4.21E-108"},{"v":2.6764e-107,"d":"2.68E-107"},"up","yes","AC105662.1","protein_coding","chr5:166300122-166310326:+","gi|109475928|ref|XP_001058198.1|",856,{"v":1e-104,"d":"1.00E-104"},"PREDICTED: fibronectin type-III domain-containing transmembrane protein C1orf233 homolog [Rattus norvegicus]","gi|672055112|ref|XM_001058198.5|",1593,0,"PREDICTED: Rattus norvegicus hypothetical protein LOC680656 (LOC680656), transcript variant X2, mRNA","D4A2Q0",334,{"v":3e-106,"d":"3.00E-106"},"Fibronectin type III domain-containing protein 10","YJL190c",207,{"v":3e-61,"d":"3.00E-61"},"COG0096","pfam00410","Ribosomal_S8","Ribosomal protein S8.","GO:0006412|translation;",".",".",".","."]
["ENSRNOG00000000552",775,49.85608959,137,8.844974773,5.636657071,2.494839798,{"v":5.7306e-108,"d":"5.73E-108"},{"v":3.6366e-107,"d":"3.64E-107"},"up","yes","Col13a1","protein_coding","chr20:29783965-29924032:-","gi|157821425|ref|NP_001102642.1|",1062,{"v":2e-126,"d":"2.00E-126"},"collagen alpha-1(XIII) chain [Rattus norvegicus]","gi|157821424|ref|NM_001109172.1|",3146,0,"Rattus norvegicus collagen, type XIII, alpha 1 (Col13a1), mRNA","Q9R1N9",390,{"v":4e-119,"d":"4.00E-119"},"Collagen alpha-1(XIII) chain",".",".",".",".","pfam01391","Collagen","Collagen triple helix repeat (20 copies). Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxyproline. Collagens are post translationally modified by proline hydroxylase to form the hydroxyproline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure.","GO:0001501|skeletal system development;GO:0001763|morphogenesis of a branching structure;GO:0001958|endochondral ossification;GO:0007160|cell-matrix adhesion;GO:0030198|extracellular matrix organization;GO:0030199|collagen fibril organization;GO:0030903|notochord development;GO:0098609|cell-cell adhesion;","GO:0005581|collagen trimer;GO:0005615|extracellular space;GO:0005911|cell-cell junction;GO:0031012|extracellular matrix;","GO:0005201|extracellular matrix structural constituent;GO:0008201|heparin binding;","K16617","COL13A; collagen type XIII alpha"]
["ENSRNOG00000004303",2847,183.1487575,1413,91.22590769,2.007639739,1.005500408,{"v":5.7958e-108,"d":"5.80E-108"},{"v":3.6739e-107,"d":"3.67E-107"},"up","yes","Timp3","protein_coding","chr7:17521919-17571839:-","gi|67972654|ref|NP_037018.2|",1030,{"v":2e-134,"d":"2.00E-134"},"metalloproteinase inhibitor 3 precursor [Rattus norvegicus]","gi|67972653|ref|NM_012886.2|",1743,0,"Rattus norvegicus TIMP metallopeptidase inhibitor 3 (Timp3), mRNA","P39876",400,{"v":3e-135,"d":"3.00E-135"},"Metalloproteinase inhibitor 3",".",".",".",".","pfam00965","TIMP","Tissue inhibitor of metalloproteinase. Members of this family are common in extracellular regions of vertebrate species","GO:0007417|central nervous system development;GO:0007568|aging;GO:0009612|response to mechanical stimulus;GO:0009725|response to hormone;GO:0010033|response to organic substance;GO:0010951|negative regulation of endopeptidase activity;GO:0014070|response to organic cyclic compound;GO:0034097|response to cytokine;GO:0042246|tissue regeneration;GO:0043200|response to amino acid;GO:0043627|response to estrogen;GO:0045861|negative regulation of proteolysis;GO:0051045|negative regulation of membrane protein ectodomain proteolysis;GO:0051593|response to folic acid;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0071310|cellular response to organic substance;GO:1903984|positive regulation of TRAIL-activated apoptotic signaling pathway;GO:1904684|negative regulation of metalloendopeptidase activity;","GO:0005576|extracellular region;GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0031012|extracellular matrix;","GO:0002020|protease binding;GO:0003674|molecular_function;GO:0008191|metalloendopeptidase inhibitor activity;GO:0008270|zinc ion binding;GO:0046872|metal ion binding;","K16866","TIMP3; metalloproteinase inhibitor 3"]
["ENSRNOG00000008515",649,41.75045438,84,5.423196211,7.698496008,2.944576626,{"v":8.9371e-108,"d":"8.94E-108"},{"v":5.6525e-107,"d":"5.65E-107"},"up","yes","Tmem45b","protein_coding","chr8:29865278-29910453:-","gi|74271857|ref|NP_001028239.1|",1477,0,"transmembrane protein 45B [Rattus norvegicus]","gi|74271856|ref|NM_001033067.1|",3446,0,"Rattus norvegicus transmembrane protein 45b (Tmem45b), mRNA","Q497B2",573,0,"Transmembrane protein 45B",".",".",".",".","pfam04819","DUF716","Family of unknown function (DUF716). This family is equally distributed in both metazoa and plants. Annotation associated with a member from Nicotiana tabacum suggest that it may be involved in response to viral attack in plants. However, no clear function has been assigned to this family.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000017601",1356,87.23207418,440,28.40721825,3.070771429,1.61860113,{"v":9.7586E-108,"d":"9.76E-108"},{"v":6.1653e-107,"d":"6.17E-107"},"up","yes","Srd5a1","protein_coding","chr1:33686391-33720461:+","gi|2507119|sp|P24008.2|S5A1_RAT",1195,{"v":2e-154,"d":"2.00E-154"},"RecName: Full=3-oxo-5-alpha-steroid 4-dehydrogenase 1; AltName: Full=SR type 1; AltName: Full=Steroid 5-alpha-reductase 1; Short=S5AR 1","gi|117558799|gb|BC127454.1|",2613,0,"Rattus norvegicus steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1), mRNA (cDNA clone MGC:156498 IMAGE:7313862), complete cds","P24008",464,{"v":7e-156,"d":"7.00E-156"},"3-oxo-5-alpha-steroid 4-dehydrogenase 1",".",".",".",".","pfam02544","Steroid_dh","3-oxo-5-alpha-steroid 4-dehydrogenase. This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalysed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor <=> 3-oxo-delta(4)-steroid + reduced acceptor. The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally. A related enzyme is also found in plants is DET2, a steroid reductase from Arabidopsis. Mutations in this enzyme cause defects in light-regulated development.","GO:0001655|urogenital system development;GO:0001889|liver development;GO:0006694|steroid biosynthetic process;GO:0006702|androgen biosynthetic process;GO:0006710|androgen catabolic process;GO:0008209|androgen metabolic process;GO:0008584|male gonad development;GO:0009267|cellular response to starvation;GO:0009410|response to xenobiotic stimulus;GO:0014070|response to organic cyclic compound;GO:0014850|response to muscle activity;GO:0016101|diterpenoid metabolic process;GO:0021510|spinal cord development;GO:0021766|hippocampus development;GO:0021794|thalamus development;GO:0021854|hypothalamus development;GO:0021983|pituitary gland development;GO:0021987|cerebral cortex development;GO:0030154|cell differentiation;GO:0030539|male genitalia development;GO:0030540|female genitalia development;GO:0032354|response to follicle-stimulating hormone;GO:0032355|response to estradiol;GO:0032869|cellular response to insulin stimulus;GO:0033574|response to testosterone;GO:0042428|serotonin metabolic process;GO:0042448|progesterone metabolic process;GO:0042747|circadian sleep/wake cycle, REM sleep;GO:0043627|response to estrogen;GO:0046661|male sex differentiation;GO:0060348|bone development;GO:0060416|response to growth hormone;GO:0060992|response to fungicide;GO:0071320|cellular response to cAMP;GO:0071363|cellular response to growth factor stimulus;GO:0071392|cellular response to estradiol stimulus;GO:0071394|cellular response to testosterone stimulus;GO:0071407|cellular response to organic cyclic compound;GO:0071549|cellular response to dexamethasone stimulus;GO:0071872|cellular response to epinephrine stimulus;","GO:0005737|cytoplasm;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0043025|neuronal cell body;GO:0043209|myelin sheath;GO:0043231|intracellular membrane-bounded organelle;GO:0048471|perinuclear region of cytoplasm;GO:0070852|cell body fiber;","GO:0003865|3-oxo-5-alpha-steroid 4-dehydrogenase activity;GO:0016491|oxidoreductase activity;GO:0033218|amide binding;GO:0047751|cholestenone 5-alpha-reductase activity;GO:0050213|progesterone 5-alpha-reductase activity;GO:0070402|NADPH binding;","K12343","SRD5A1; 3-oxo-5-alpha-steroid 4-dehydrogenase 1 [EC:1.3.1.22]"]
["ENSRNOG00000001156",1417,91.15623091,476,30.7314452,2.966220115,1.56862566,{"v":1.3717E-107,"d":"1.37E-107"},{"v":8.6468E-107,"d":"8.65E-107"},"up","yes","Msi1","protein_coding","chr12:41158599-41191076:-","gi|22507308|ref|NP_683688.1|",1758,0,"RNA-binding protein Musashi homolog 1 [Rattus norvegicus]","gi|918617799|ref|XM_013520366.1|",1482,0,"PREDICTED: Chinchilla lanigera musashi RNA-binding protein 1 (Msi1), transcript variant X1, mRNA","Q8K3P4",681,0,"RNA-binding protein Musashi homolog 1",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0009725|response to hormone;GO:0030855|epithelial cell differentiation;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005844|polysome;","GO:0003723|RNA binding;GO:0003727|single-stranded RNA binding;GO:0008266|poly(U) RNA binding;GO:0042802|identical protein binding;","K14411","MSI; RNA-binding protein Musashi"]
["ENSRNOG00000027433",1375,88.4543525,452,29.18196056,3.031131247,1.599856322,{"v":1.9684e-107,"d":"1.97E-107"},{"v":1.2382e-106,"d":"1.24E-106"},"up","yes","Akr1b8","protein_coding","chr4:62997161-63010097:+","gi|149065228|gb|EDM15304.1|",1536,0,"rCG27994 [Rattus norvegicus]","gi|51480423|gb|BC080239.1|",2994,0,"Rattus norvegicus aldo-keto reductase family 1, member B8, mRNA (cDNA clone IMAGE:7100613), with apparent retained intron","P45377",567,0,"Aldose reductase-related protein 2","slr0942",223,{"v":4e-64,"d":"4.00E-64"},"COG0656","pfam00248","Aldo_ket_red","Aldo/keto reductase family. This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.",".",".",".",".","."]
["ENSRNOG00000001189",1734,111.5489798,671,43.32100783,2.574939629,1.364538608,{"v":6.0654e-107,"d":"6.07E-107"},{"v":3.8068e-106,"d":"3.81E-106"},"up","yes","Sik1","protein_coding","chr20:9947396-9958991:-","gi|148747268|ref|NP_067725.2|",3568,0,"serine/threonine-protein kinase SIK1 [Rattus norvegicus]","gi|6492127|gb|AF106937.1|AF106937",3304,0,"Rattus norvegicus protein kinase KID2 (Kid2) mRNA, complete cds","Q9R1U5",1379,0,"Serine/threonine-protein kinase SIK1",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0002028|regulation of sodium ion transport;GO:0006468|protein phosphorylation;GO:0007346|regulation of mitotic cell cycle;GO:0010830|regulation of myotube differentiation;GO:0010868|negative regulation of triglyceride biosynthetic process;GO:0032792|negative regulation of CREB transcription factor activity;GO:0035556|intracellular signal transduction;GO:0042149|cellular response to glucose starvation;GO:0043153|entrainment of circadian clock by photoperiod;GO:0043276|anoikis;GO:0045595|regulation of cell differentiation;GO:0045721|negative regulation of gluconeogenesis;GO:0046777|protein autophosphorylation;GO:0048511|rhythmic process;GO:0055007|cardiac muscle cell differentiation;GO:2000210|positive regulation of anoikis;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0000287|magnesium ion binding;GO:0004674|protein serine/threonine kinase activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0008140|cAMP response element binding protein binding;GO:0019901|protein kinase binding;GO:0042826|histone deacetylase binding;GO:0071889|14-3-3 protein binding;","K19008","SIK1; serine/threonine-protein kinase SIK1 [EC:2.7.11.1]"]
["ENSRNOG00000006839",1710,110.0050493,657,42.41714179,2.593410226,1.37485043,{"v":1.0973e-106,"d":"1.10E-106"},{"v":6.8644e-106,"d":"6.86E-106"},"up","yes","Arl5a","protein_coding","chr3:36880712-36903211:-","gi|16758876|ref|NP_446431.1|",955,{"v":7e-120,"d":"7.00E-120"},"ADP-ribosylation factor-like protein 5A [Rattus norvegicus]","gi|1150555|emb|X78604.1|",2711,0,"R.norvegicus (Sprague Dawley) ARL5 mRNA for ARF-like protein 5","P51646",372,{"v":2E-121,"d":"2.00E-121"},"ADP-ribosylation factor-like protein 5A","YDL192w",191,{"v":7e-55,"d":"7.00E-55"},"COG1100","pfam00025","Arf","ADP-ribosylation factor family. Pfam combines a number of different Prosite families together","GO:0006886|intracellular protein transport;GO:0016192|vesicle-mediated transport;GO:1903292|protein localization to Golgi membrane;","GO:0005737|cytoplasm;GO:0005802|trans-Golgi network;","GO:0003924|GTPase activity;GO:0005525|GTP binding;","K07949","ARL5A; ADP-ribosylation factor-like protein 5A"]
["ENSRNOG00000002258",877,56.41779429,188,12.13762962,4.648172343,2.216663561,{"v":3.0279e-106,"d":"3.03E-106"},{"v":1.8838e-105,"d":"1.88E-105"},"up","yes","Tmem150c","protein_coding","chr14:9508515-9525298:+","gi|157820971|ref|NP_001101824.1|",1106,{"v":3e-141,"d":"3.00E-141"},"transmembrane protein 150C [Rattus norvegicus]","gi|672075781|ref|XM_006250671.2|",2706,0,"PREDICTED: Rattus norvegicus transmembrane protein 150C (Tmem150c), transcript variant X2, mRNA","B5DFH9",430,{"v":1E-142,"d":"1.00E-142"},"Transmembrane protein 150C",".",".",".",".","pfam10277","Frag1","Frag1/DRAM/Sfk1 family. This family includes Frag1, DRAM and Sfk1 proteins. Frag1 (FGF receptor activating protein 1) is a protein that is conserved from fungi to humans. There are four potential iso-prenylation sites throughout the peptide, viz CILW, CIIW and CIGL. Frag1 is a membrane-spanning protein that is ubiquitously expressed in adult tissues suggesting an important cellular function. Dram is a family of proteins conserved from nematodes to humans with six hydrophobic transmembrane regions and an Endoplasmic Reticulum signal peptide. It is a lysosomal protein that induces macro-autophagy as an effector of p53-mediated death, where p53 is the tumor-suppressor gene that is frequently mutated in cancer. Expression of Dram is stress-induced. This region is also part of a family of small plasma membrane proteins, referred to as Sfk1, that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, thus allowing proper localisation of Stt4p to the actin cytoskeleton.","GO:0019230|proprioception;GO:0034220|ion transmembrane transport;GO:0071260|cellular response to mechanical stimulus;","GO:0005765|lysosomal membrane;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;","GO:0008381|mechanosensitive ion channel activity;","K21846","TMEM150; transmembrane protein 150"]
["ENSRNOG00000014251",2113,135.9302159,922,59.5260346,2.283542265,1.191273492,{"v":1.6824E-105,"d":"1.68E-105"},{"v":1.0433e-104,"d":"1.04E-104"},"up","yes","Capn5","protein_coding","chr1:152416252-152472923:-","gi|672037661|ref|XP_006229791.2|",3967,0,"PREDICTED: calpain-5 isoform X1 [Rattus norvegicus]","gi|672037660|ref|XM_006229729.2|",4367,0,"PREDICTED: Rattus norvegicus calpain 5 (Capn5), transcript variant X1, mRNA","Q8R4C0",1290,0,"Calpain-5",".",".",".",".","pfam00648","Peptidase_C2","Calpain family cysteine protease.","GO:0001541|ovarian follicle development;GO:0001553|luteinization;GO:0006508|proteolysis;GO:0060014|granulosa cell differentiation;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0009986|cell surface;GO:0045202|synapse;","GO:0003674|molecular_function;GO:0004198|calcium-dependent cysteine-type endopeptidase activity;","K08574","CAPN5; calpain-5 [EC:3.4.22.-]"]
["ENSRNOG00000015239",2777,178.6456268,1380,89.09536632,2.0051057,1.003678291,{"v":4.7793e-105,"d":"4.78E-105"},{"v":2.9541e-104,"d":"2.95E-104"},"up","yes","Ginm1","protein_coding","chr1:2246394-2262217:-","gi|564295942|ref|XP_006222879.1|",1346,{"v":1E-179,"d":"1.00E-179"},"PREDICTED: glycoprotein integral membrane protein 1 isoform X3 [Rattus norvegicus]","gi|672012429|ref|XM_006222817.2|",1422,0,"PREDICTED: Rattus norvegicus glycoprotein integral membrane 1 (Ginm1), transcript variant X3, mRNA","Q91WR6",442,{"v":4e-149,"d":"4.00E-149"},"Glycoprotein integral membrane protein 1",".",".",".",".","pfam05140","ResB","ResB-like family. This family includes both ResB and cytochrome c biogenesis proteins. Mutations in ResB indicate that they are essential for growth. ResB is predicted to be a transmembrane protein.",".",".",".",".","."]
["ENSRNOG00000032989",1012,65.10240344,260,16.78608351,3.878355746,1.955445142,{"v":1.7575e-104,"d":"1.76E-104"},{"v":1.077E-103,"d":"1.08E-103"},"up","yes","Lrrn4","protein_coding","chr3:120139410-120150831:-","gi|109470864|ref|XP_001081242.1|",3504,0,"PREDICTED: leucine-rich repeat neuronal protein 4 [Rattus norvegicus]","gi|672017367|ref|XM_001081242.4|",3172,0,"PREDICTED: Rattus norvegicus leucine rich repeat neuronal 4 (Lrrn4), mRNA","P59383",1113,0,"Leucine-rich repeat neuronal protein 4",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.","GO:0007616|long-term memory;GO:0008542|visual learning;","GO:0005887|integral component of plasma membrane;",".","K24493","LRRN4; leucine-rich repeat neuronal protein 4"]
["ENSRNOG00000008012",949,61.04958584,229,14.78466586,4.129250293,2.04587987,{"v":5.9803e-104,"d":"5.98E-104"},{"v":3.6491e-103,"d":"3.65E-103"},"up","yes","Abcb1b","protein_coding","chr4:25158362-25442709:-","gi|25453402|ref|NP_596892.1|",6086,0,"ATP binding cassette subfamily B member 1 [Rattus norvegicus]","gi|672048788|ref|XM_006235994.2|",2119,0,"PREDICTED: Rattus norvegicus ATP-binding cassette, sub-family B (MDR/TAP), member 1A (Abcb1a), transcript variant X1, mRNA","P21447",2231,0,"Multidrug resistance protein 1A","SPCC663.03",811,0,"COG1132","pfam00664","ABC_membrane","ABC transporter transmembrane region. This family represents a unit of six transmembrane helices. Many members of the ABC transporter family (pfam00005) have two such regions.","GO:0000086|G2/M transition of mitotic cell cycle;GO:0001666|response to hypoxia;GO:0001890|placenta development;GO:0007420|brain development;GO:0007595|lactation;GO:0007623|circadian rhythm;GO:0009410|response to xenobiotic stimulus;GO:0009914|hormone transport;GO:0010033|response to organic substance;GO:0010046|response to mycotoxin;GO:0010212|response to ionizing radiation;GO:0014045|establishment of endothelial blood-brain barrier;GO:0014070|response to organic cyclic compound;GO:0014072|response to isoquinoline alkaloid;GO:0031667|response to nutrient levels;GO:0032355|response to estradiol;GO:0032376|positive regulation of cholesterol transport;GO:0032496|response to lipopolysaccharide;GO:0032782|bile acid secretion;GO:0033189|response to vitamin A;GO:0033231|carbohydrate export;GO:0033280|response to vitamin D;GO:0033595|response to genistein;GO:0033762|response to glucagon;GO:0035633|maintenance of permeability of blood-brain barrier;GO:0036146|cellular response to mycotoxin;GO:0042908|xenobiotic transport;GO:0043215|daunorubicin transport;GO:0043278|response to morphine;GO:0045332|phospholipid translocation;GO:0046685|response to arsenic-containing substance;GO:0046686|response to cadmium ion;GO:0046865|terpenoid transport;GO:0047484|regulation of response to osmotic stress;GO:0048545|response to steroid hormone;GO:0050892|intestinal absorption;GO:0051384|response to glucocorticoid;GO:0055085|transmembrane transport;GO:0055088|lipid homeostasis;GO:0060548|negative regulation of cell death;GO:0060856|establishment of blood-brain barrier;GO:0061092|positive regulation of phospholipid translocation;GO:0061843|Sertoli cell barrier remodeling;GO:0070633|transepithelial transport;GO:0071217|cellular response to external biotic stimulus;GO:0071222|cellular response to lipopolysaccharide;GO:0071236|cellular response to antibiotic;GO:0071312|cellular response to alkaloid;GO:0071356|cellular response to tumor necrosis factor;GO:0071392|cellular response to estradiol stimulus;GO:0071407|cellular response to organic cyclic compound;GO:0071475|cellular hyperosmotic salinity response;GO:0071548|response to dexamethasone;GO:0071549|cellular response to dexamethasone stimulus;GO:0072089|stem cell proliferation;GO:0097068|response to thyroxine;GO:0097327|response to antineoplastic agent;GO:0099040|ceramide translocation;GO:0140115|export across plasma membrane;GO:1901529|positive regulation of anion channel activity;GO:1901557|response to fenofibrate;GO:1902065|response to L-glutamate;GO:1902396|protein localization to bicellular tight junction;GO:1903413|cellular response to bile acid;GO:1903416|response to glycoside;GO:1904446|positive regulation of establishment of Sertoli cell barrier;GO:1904478|regulation of intestinal absorption;GO:1905039|carboxylic acid transmembrane transport;GO:1905231|cellular response to borneol;GO:1905232|cellular response to L-glutamate;GO:1905233|response to codeine;GO:1905235|response to quercetin;GO:1905237|response to cyclosporin A;GO:1990961|drug transmembrane export;GO:1990962|drug transport across blood-brain barrier;GO:1990963|establishment of blood-retinal barrier;GO:2001025|positive regulation of response to drug;GO:2001140|positive regulation of phospholipid transport;GO:2001225|regulation of chloride transport;","GO:0000139|Golgi membrane;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005925|focal adhesion;GO:0009986|cell surface;GO:0015629|actin cytoskeleton;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0030136|clathrin-coated vesicle;GO:0031526|brush border membrane;GO:0045121|membrane raft;GO:0045177|apical part of cell;GO:0046581|intercellular canaliculus;GO:0098591|external side of apical plasma membrane;","GO:0005515|protein binding;GO:0005524|ATP binding;GO:0008559|xenobiotic transmembrane transporting ATPase activity;GO:0015562|efflux transmembrane transporter activity;GO:0016887|ATPase activity;GO:0022857|transmembrane transporter activity;GO:0031625|ubiquitin protein ligase binding;GO:0042626|ATPase activity, coupled to transmembrane movement of substances;GO:0042910|xenobiotic transmembrane transporter activity;GO:0046943|carboxylic acid transmembrane transporter activity;GO:0090554|phosphatidylcholine-translocating ATPase activity;GO:0090555|phosphatidylethanolamine-translocating ATPase activity;GO:0099038|ceramide-translocating ATPase activity;","K05658","ABCB1, CD243; ATP-binding cassette, subfamily B (MDR/TAP), member 1 [EC:7.6.2.2]K05658; K05659"]
["ENSRNOG00000007407",1660,106.7885274,642,41.4487139,2.576401469,1.36535742,{"v":1.4856e-102,"d":"1.49E-102"},{"v":8.9596e-102,"d":"8.96E-102"},"up","yes","Ndufa12","protein_coding","chr7:28771330-28798315:+","gi|164565371|ref|NP_001100251.2|",782,{"v":6e-104,"d":"6.00E-104"},"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [Rattus norvegicus]","gi|164565370|ref|NM_001106781.2|",549,0,"Rattus norvegicus NADH:ubiquinone oxidoreductase subunit A12 (Ndufa12), mRNA","Q7TMF3",291,{"v":1E-99,"d":"1.00E-99"},"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12","AGc2444",58.5,{"v":1E-10,"d":"1.00E-10"},"COG3761","pfam05071","NDUFA12","NADH ubiquinone oxidoreductase subunit NDUFA12. This family contains the 17.2 kD subunit of complex I (NDUFA12) and its homologues. The family also contains a second related eukaryotic protein of unknown function.","GO:0006979|response to oxidative stress;GO:0032981|mitochondrial respiratory chain complex I assembly;GO:0042775|mitochondrial ATP synthesis coupled electron transport;","GO:0005739|mitochondrion;GO:0005747|mitochondrial respiratory chain complex I;GO:0005829|cytosol;",".","K11352","NDUFA12; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 12"]
["ENSRNOG00000020837",430,27.66208842,11,0.710180456,38.95078804,5.283580612,{"v":2.6049e-102,"d":"2.60E-102"},{"v":1.5677E-101,"d":"1.57E-101"},"up","yes","Cd300lg","protein_coding","chr10:86991921-87008733:+","gi|392331943|ref|XP_003752434.1|",1868,0,"PREDICTED: CMRF35-like molecule 9 isoform X1 [Rattus norvegicus]","gi|672025293|ref|XM_003752386.3|",2069,0,"PREDICTED: Rattus norvegicus Cd300 molecule-like family member G (Cd300lg), transcript variant X1, mRNA","Q1ERP8",283,{"v":4e-87,"d":"4.00E-87"},"CMRF35-like molecule 9",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0002414|immunoglobulin transcytosis in epithelial cells;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;","GO:0001791|IgM binding;GO:0004888|transmembrane signaling receptor activity;","K16663","CD300LG, NEPMUCIN; CMRF35-like molecule 9"]
["ENSRNOG00000008543",1802,115.9234496,735,47.45296685,2.442912579,1.288602237,{"v":7.5251e-102,"d":"7.53E-102"},{"v":4.5003E-101,"d":"4.50E-101"},"up","yes","Pdlim2","protein_coding","chr15:45237477-45249242:-","gi|564386880|ref|XP_006252317.1|",1569,0,"PREDICTED: PDZ and LIM domain protein 2 isoform X2 [Rattus norvegicus]","gi|56090294|ref|NM_001007622.1|",1528,0,"Rattus norvegicus PDZ and LIM domain 2 (Pdlim2), mRNA","Q6AYD6",605,0,"PDZ and LIM domain protein 2",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.","GO:0007507|heart development;GO:0030036|actin cytoskeleton organization;GO:0061061|muscle structure development;","GO:0001725|stress fiber;GO:0005912|adherens junction;GO:0030018|Z disc;GO:0030864|cortical actin cytoskeleton;GO:0031941|filamentous actin;","GO:0003779|actin binding;GO:0005515|protein binding;GO:0031005|filamin binding;GO:0032036|myosin heavy chain binding;GO:0046872|metal ion binding;GO:0051371|muscle alpha-actinin binding;GO:0051393|alpha-actinin binding;","K23353","PDLIM1_2_3_4; PDZ and LIM domain protein 1/2/3/4"]
["ENSRNOG00000017069",2010,129.3041808,871,56.23337976,2.299420403,1.201270258,{"v":9.1316e-102,"d":"9.13E-102"},{"v":5.4554e-101,"d":"5.46E-101"},"up","yes","Mark4","protein_coding","chr1:79068904-79108556:-","gi|564326670|ref|XP_006228534.1|",3292,0,"PREDICTED: MAP/microtubule affinity-regulating kinase 4 isoform X1 [Rattus norvegicus]","gi|755519417|ref|XM_006539829.2|",2738,0,"PREDICTED: Mus musculus MAP/microtubule affinity-regulating kinase 4 (Mark4), transcript variant X1, mRNA","Q8CIP4",1145,0,"MAP/microtubule affinity-regulating kinase 4",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0000226|microtubule cytoskeleton organization;GO:0001578|microtubule bundle formation;GO:0006468|protein phosphorylation;GO:0007399|nervous system development;GO:0008284|positive regulation of cell proliferation;GO:0035556|intracellular signal transduction;GO:0044782|cilium organization;GO:0045724|positive regulation of cilium assembly;GO:0046605|regulation of centrosome cycle;GO:1904781|positive regulation of protein localization to centrosome;","GO:0000930|gamma-tubulin complex;GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0005815|microtubule organizing center;GO:0005829|cytosol;GO:0005874|microtubule;GO:0015630|microtubule cytoskeleton;GO:0030425|dendrite;GO:0030496|midbody;GO:0036064|ciliary basal body;GO:0043005|neuron projection;","GO:0004674|protein serine/threonine kinase activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0008017|microtubule binding;GO:0043015|gamma-tubulin binding;GO:0050321|tau-protein kinase activity;","K08798","MARK; MAP/microtubule affinity-regulating kinase [EC:2.7.11.1]"]
["ENSRNOG00000014338",1366,87.87537856,466,30.0858266,2.920823141,1.546375004,{"v":1.102e-101,"d":"1.10E-101"},{"v":6.5767e-101,"d":"6.58E-101"},"up","yes","Slc25a25","protein_coding","chr3:15708703-15742216:-","gi|28972868|dbj|BAC65850.1|",2697,0,"mKIAA1896 protein [Mus musculus]","gi|672045127|ref|XM_006233933.2|",3614,0,"PREDICTED: Rattus norvegicus solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25 (Slc25a25), transcript variant X3, mRNA","Q8K3P6",854,0,"Calcium-binding mitochondrial carrier protein SCaMC-2",".",".",".",".","pfam00153","Mito_carr","Mitochondrial carrier protein.","GO:0002021|response to dietary excess;GO:0014823|response to activity;GO:0015867|ATP transport;GO:0032094|response to food;GO:0035264|multicellular organism growth;GO:0043010|camera-type eye development;GO:0045333|cellular respiration;GO:0046034|ATP metabolic process;GO:0060612|adipose tissue development;GO:0070588|calcium ion transmembrane transport;","GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0016021|integral component of membrane;","GO:0005347|ATP transmembrane transporter activity;GO:0005509|calcium ion binding;","K14684","SLC25A23S; solute carrier family 25 (mitochondrial phosphate transporter), member 23/24/25/41"]
["ENSRNOG00000018574",1467,94.37275282,527,34.02410004,2.773703131,1.471813385,{"v":1.612E-101,"d":"1.61E-101"},{"v":9.6103e-101,"d":"9.61E-101"},"up","yes","Qsox2","protein_coding","chr3:9034994-9064664:-","gi|157821921|ref|NP_001102904.1|",3463,0,"sulfhydryl oxidase 2 [Rattus norvegicus]","gi|157821920|ref|NM_001109434.1|",4634,0,"Rattus norvegicus quiescin sulfhydryl oxidase 2 (Qsox2), mRNA","Q3TMX7",1232,0,"Sulfhydryl oxidase 2",".",".",".",".","pfam04777","Evr1_Alr","Erv1 / Alr family. Biogenesis of Fe/S clusters involves a number of essential mitochondrial proteins. Erv1p of Saccharomyces cerevisiae mitochondria is required for the maturation of Fe/S proteins in the cytosol. The ALR (augmenter of liver regeneration) represents a mammalian orthologue of yeast Erv1p. Both Erv1p and full-length ALR are located in the mitochondrial intermembrane an d it thought to operate downstream of the mitochondrial ABC transporter.","GO:0006457|protein folding;","GO:0005615|extracellular space;GO:0005654|nucleoplasm;GO:0005794|Golgi apparatus;GO:0030173|integral component of Golgi membrane;","GO:0003756|protein disulfide isomerase activity;GO:0016971|flavin-linked sulfhydryl oxidase activity;","K10758","QSOX; thiol oxidase [EC:1.8.3.2]"]
["ENSRNOG00000047573",672,43.23005446,106,6.843557123,6.316898315,2.659216349,{"v":1.3179e-100,"d":"1.32E-100"},{"v":7.8244e-100,"d":"7.82E-100"},"up","yes","Ttc39a","protein_coding","chr5:124151760-124204973:+","gi|197386204|ref|NP_001127991.1|",3098,0,"tetratricopeptide repeat protein 39A [Rattus norvegicus]","gi|197386203|ref|NM_001134519.1|",2644,0,"Rattus norvegicus tetratricopeptide repeat domain 39A (Ttc39a), mRNA",".",".",".",".",".",".",".",".","pfam10300","DUF3808","Protein of unknown function (DUF3808). This is a family of proteins conserved from fungi to humans. Members of this family also carry a TPR_2 domain pfam07719 at their C-terminus.",".","GO:0005813|centrosome;",".","K24943","TTC39; tetratricopeptide repeat protein 39"]
["ENSRNOG00000008534",837,53.84457676,183,11.81482032,4.557375848,2.188203355,{"v":6.5567E-100,"d":"6.56E-100"},{"v":3.8605e-99,"d":"3.86E-99"},"up","yes","Dusp15","protein_coding","chr3:141408498-141418999:-","gi|348605122|ref|NP_001102068.2|",1129,{"v":3e-143,"d":"3.00E-143"},"dual specificity protein phosphatase 15 isoform 1 [Rattus norvegicus]","gi|348605121|ref|NM_001108598.2|",3130,0,"Rattus norvegicus dual specificity phosphatase 15 (Dusp15), transcript variant 1, mRNA","B4F7B7",416,{"v":4E-136,"d":"4.00E-136"},"Dual specificity protein phosphatase 15","YIR026c",59.7,2E-8,"COG2453","pfam00782","DSPc","Dual specificity phosphatase, catalytic domain. Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a \"recognition\" region.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0016311|dephosphorylation;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0042127|regulation of cell proliferation;GO:0046330|positive regulation of JNK cascade;GO:0048713|regulation of oligodendrocyte differentiation;GO:0070374|positive regulation of ERK1 and ERK2 cascade;","GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0004725|protein tyrosine phosphatase activity;GO:0008138|protein tyrosine/serine/threonine phosphatase activity;GO:0016791|phosphatase activity;","K14165","K14165; atypical dual specificity phosphatase [EC:3.1.3.16 3.1.3.48]"]
["ENSRNOG00000038297",1817,116.8884062,755,48.74420404,2.397995997,1.261829251,{"v":1.9363e-99,"d":"1.94E-99"},{"v":1.1354E-98,"d":"1.14E-98"},"up","yes","Plekhd1","protein_coding","chr6:100340655-100371941:+","gi|189011673|ref|NP_001121038.1|",1926,0,"pleckstrin homology domain-containing family D member 1 [Rattus norvegicus]","gi|189011672|ref|NM_001127566.1|",3279,0,"Rattus norvegicus pleckstrin homology and coiled-coil domain containing D1 (Plekhd1), mRNA",".",".",".",".",".",".",".",".","pfam00169","PH","PH domain. PH stands for pleckstrin homology.",".",".",".",".","."]
["ENSRNOG00000009296",1048,67.41829922,297,19.17487232,3.51597122,1.813923261,{"v":6.57413e-98,"d":"6.57E-98"},{"v":3.79645e-97,"d":"3.80E-97"},"up","yes","Snapc1","protein_coding","chr6:92684752-92707746:+","gi|157820321|ref|NP_001101503.1|",1941,0,"snRNA-activating protein complex subunit 1 [Rattus norvegicus]","gi|171847085|gb|BC161969.1|",1706,0,"Rattus norvegicus small nuclear RNA activating complex, polypeptide 1, mRNA (cDNA clone MGC:187778 IMAGE:9028949), complete cds","Q8K0S9",673,0,"snRNA-activating protein complex subunit 1",".",".",".",".","pfam09808","SNAPc_SNAP43","Small nuclear RNA activating complex (SNAPc), subunit SNAP43. Members of this family are part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. They bind to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Furthermore, they also recruit TBP and BRF2 to the U6 snRNA TATA box.","GO:0042795|snRNA transcription by RNA polymerase II;GO:0042796|snRNA transcription by RNA polymerase III;","GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0019185|snRNA-activating protein complex;","GO:0043565|sequence-specific DNA binding;","K15208","SNAPC1; snRNA-activating protein complex subunit 1"]
["ENSRNOG00000016692",1986,127.7602502,876,56.55618906,2.258996802,1.175682229,{"v":2.94039e-97,"d":"2.94E-97"},{"v":1.68779e-96,"d":"1.69E-96"},"up","yes","Hsdl2","protein_coding","chr5:74443872-74479839:+","gi|672052693|ref|XP_008761958.1|",1358,{"v":2E-175,"d":"2.00E-175"},"PREDICTED: hydroxysteroid dehydrogenase-like protein 2 isoform X2 [Rattus norvegicus]","gi|71043857|ref|NM_001025697.1|",1930,0,"Rattus norvegicus hydroxysteroid dehydrogenase like 2 (Hsdl2), mRNA","Q4V8F9",527,{"v":4E-176,"d":"4.00E-176"},"Hydroxysteroid dehydrogenase-like protein 2","CC0400",277,{"v":2e-84,"d":"2.00E-84"},"COG1028","pfam02036","SCP2","SCP-2 sterol transfer family. This domain is involved in binding sterols. It is found in the SCP2 protein, as well as the C terminus of the enzyme estradiol 17 beta-dehydrogenase EC:1.1.1.62. The UNC-24 protein contains an SPFH domain pfam01145.",".","GO:0005739|mitochondrion;GO:0005777|peroxisome;","GO:0016491|oxidoreductase activity;",".","."]
["ENSRNOG00000063761",498,32.03655822,45,2.905283684,11.02699829,3.462968216,{"v":8.62305e-96,"d":"8.62E-96"},{"v":4.92489E-95,"d":"4.92E-95"},"up","yes","ENSRNOG00000063761","lncRNA","chr3:164974985-164977741:+","gi|148682322|gb|EDL14269.1|",173,{"v":2e-11,"d":"2.00E-11"},"mCG146167, partial [Mus musculus]","gi|356995948|gb|AC240630.5|",2435,0,"Rattus norvegicus Y Chr BAC RNAEX-220B13 (Amplicon Express Rat SHR-Akr BAC library) complete sequence","P31789",53.5,7e-06,"Envelope glycoprotein",".",".",".",".","pfam07248","DUF1431","Protein of unknown function (DUF1431). This family contains a number of Drosophila melanogaster proteins of unknown function. These contain several conserved cysteine residues.",".",".",".",".","."]
["ENSRNOG00000060867",440,28.3053928,2,0.129123719,219.2114118,7.776179094,{"v":1.02501e-95,"d":"1.03E-95"},{"v":5.84244e-95,"d":"5.84E-95"},"up","yes","Rln1","protein_coding","chr1:227079966-227082882:-","gi|564333247|ref|XP_006231258.1|",899,{"v":1E-119,"d":"1.00E-119"},"PREDICTED: prorelaxin 1 isoform X1 [Rattus norvegicus]","gi|672040050|ref|XM_006231196.2|",781,0,"PREDICTED: Rattus norvegicus relaxin 1 (Rln1), transcript variant X1, mRNA","P01347",345,{"v":4e-119,"d":"4.00E-119"},"Prorelaxin 1",".",".",".",".","pfam00049","Insulin","Insulin/IGF/Relaxin family. Superfamily includes insulins; relaxins; insulin-like growth factor; and bombyxin. All are secreted regulatory hormones. Disulfide rich, all-alpha fold. Alignment includes B chain, linker (which is processed out of the final product), and A chain.","GO:0007188|adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007283|spermatogenesis;GO:0010749|regulation of nitric oxide mediated signal transduction;GO:0042127|regulation of cell proliferation;GO:0042981|regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0048589|developmental growth;GO:0050878|regulation of body fluid levels;GO:0060443|mammary gland morphogenesis;GO:0060618|nipple development;GO:0060736|prostate gland growth;","GO:0005576|extracellular region;","GO:0005102|signaling receptor binding;GO:0005179|hormone activity;","K21998","RLN1_2; relaxin 1/2"]
["ENSRNOG00000017188",1953,125.6373458,862,55.65232302,2.257540008,1.174751555,{"v":1.4816E-95,"d":"1.48E-95"},{"v":8.43659E-95,"d":"8.44E-95"},"up","yes","Cyp27a1","protein_coding","chr9:76264860-76294551:+","gi|149016121|gb|EDL75367.1|",2882,0,"rCG24013, isoform CRA_a [Rattus norvegicus]","gi|693582831|ref|NM_178847.3|",2129,0,"Rattus norvegicus cytochrome P450, family 27, subfamily a, polypeptide 1 (Cyp27a1), mRNA","P17178",1082,0,"Sterol 26-hydroxylase, mitochondrial","alr1450",109,{"v":2e-24,"d":"2.00E-24"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0006699|bile acid biosynthetic process;GO:0006700|C21-steroid hormone biosynthetic process;GO:0006706|steroid catabolic process;GO:0006707|cholesterol catabolic process;GO:0008203|cholesterol metabolic process;GO:0036378|calcitriol biosynthetic process from calciol;","GO:0005739|mitochondrion;GO:0005740|mitochondrial envelope;GO:0005743|mitochondrial inner membrane;GO:0016020|membrane;","GO:0005506|iron ion binding;GO:0008123|cholesterol 7-alpha-monooxygenase activity;GO:0008386|cholesterol monooxygenase (side-chain-cleaving) activity;GO:0020037|heme binding;GO:0030343|vitamin D3 25-hydroxylase activity;GO:0030544|Hsp70 protein binding;GO:0031073|cholesterol 26-hydroxylase activity;GO:0047748|cholestanetetraol 26-dehydrogenase activity;GO:0047749|cholestanetriol 26-monooxygenase activity;","K00488","CYP27A1; cholestanetriol 26-monooxygenase [EC:1.14.15.15]"]
["ENSRNOG00000017766",1206,77.58250845,393,25.37281084,3.057702551,1.61244807,{"v":1.61401E-95,"d":"1.61E-95"},{"v":9.18136e-95,"d":"9.18E-95"},"up","yes","Ca12","protein_coding","chr8:67274359-67330440:+","gi|564364325|ref|XP_006243372.1|",1817,0,"PREDICTED: carbonic anhydrase 12 isoform X1 [Rattus norvegicus]","gi|672062154|ref|XM_006243310.2|",3749,0,"PREDICTED: Rattus norvegicus carbonic anyhydrase 12 (Car12), transcript variant X1, mRNA","Q8CI85",678,0,"Carbonic anhydrase 12","BH0360",104,{"v":3E-23,"d":"3.00E-23"},"COG3338","pfam00194","Carb_anhydrase","Eukaryotic-type carbonic anhydrase.","GO:0006730|one-carbon metabolic process;GO:0055064|chloride ion homeostasis;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004089|carbonate dehydratase activity;GO:0008270|zinc ion binding;GO:0016836|hydro-lyase activity;","K01672","CA; carbonic anhydrase [EC:4.2.1.1]"]
["ENSRNOG00000013737",1391,89.48363952,504,32.53917727,2.750027721,1.459446162,{"v":3.53401e-95,"d":"3.53E-95"},{"v":2.00834e-94,"d":"2.01E-94"},"up","yes","Bcar3","protein_coding","chr2:210525260-210638798:+","gi|157819543|ref|NP_001101192.1|",4181,0,"breast cancer anti-estrogen resistance protein 3 [Rattus norvegicus]","gi|157819542|ref|NM_001107722.1|",3337,0,"Rattus norvegicus breast cancer anti-estrogen resistance 3 (Bcar3), mRNA","Q9QZK2",1509,0,"Breast cancer anti-estrogen resistance protein 3",".",".",".",".","pfam00017","SH2","SH2 domain.","GO:0002089|lens morphogenesis in camera-type eye;GO:0007264|small GTPase mediated signal transduction;GO:0008286|insulin receptor signaling pathway;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0043410|positive regulation of MAPK cascade;GO:0043547|positive regulation of GTPase activity;GO:0045740|positive regulation of DNA replication;GO:0045742|positive regulation of epidermal growth factor receptor signaling pathway;GO:0086100|endothelin receptor signaling pathway;","GO:0005737|cytoplasm;GO:0005925|focal adhesion;GO:0016020|membrane;","GO:0001784|phosphotyrosine residue binding;GO:0005085|guanyl-nucleotide exchange factor activity;GO:0005515|protein binding;GO:0019900|kinase binding;","K23688","BCAR3, SH2D3B; breast cancer anti-estrogen resistance protein 3"]
["ENSRNOG00000018413",1420,91.34922222,522,33.70129074,2.710555596,1.438588598,{"v":4.30999e-95,"d":"4.31E-95"},{"v":2.44446e-94,"d":"2.44E-94"},"up","yes","Per3","protein_coding","chr5:161459533-161495607:-","gi|564354321|ref|XP_006239563.1|",5735,0,"PREDICTED: period circadian protein homolog 3 isoform X2 [Rattus norvegicus]","gi|672054644|ref|XM_006239501.2|",4941,0,"PREDICTED: Rattus norvegicus period circadian clock 3 (Per3), transcript variant X2, mRNA","Q8CJE2",2100,0,"Period circadian protein homolog 3",".",".",".",".","pfam12114","Period_C","Period protein 2/3C-terminal region. This domain is found in eukaryotes. This domain is typically between 164 to 200 amino acids in length. This domain is found associated with pfam08447.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0007623|circadian rhythm;GO:0032922|circadian regulation of gene expression;GO:0043153|entrainment of circadian clock by photoperiod;GO:0045187|regulation of circadian sleep/wake cycle, sleep;GO:0050821|protein stabilization;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0001222|transcription corepressor binding;GO:0019900|kinase binding;GO:0031625|ubiquitin protein ligase binding;","K21945","PER3; period circadian protein 3"]
["ENSRNOG00000031789",1850,119.0113106,796,51.39124029,2.315789811,1.211504316,{"v":4.64245e-95,"d":"4.64E-95"},{"v":2.6304e-94,"d":"2.63E-94"},"up","yes","Rangap1","protein_coding","chr7:113224703-113250438:-","gi|148672614|gb|EDL04561.1|",2666,0,"RAN GTPase activating protein 1, isoform CRA_b, partial [Mus musculus]","gi|349501085|ref|NM_001244855.1|",2708,0,"Rattus norvegicus RAN GTPase activating protein 1 (Rangap1), mRNA","P46061",968,0,"Ran GTPase-activating protein 1","SPAC22E12.07",124,{"v":3e-29,"d":"3.00E-29"},"COG5238","pfam07834","RanGAP1_C","RanGAP1 C-terminal domain. Ran-GTPase activating protein 1 (RanGAP1) is a GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Its C-terminal domain is required for RanGAP1 localisation at the vertebrate nuclear pore complex, and is sumoylated by the small ubiquitin-related modifier protein (SUMO-1). This domain is composed almost entirely of helical substructures that are organized into an alpha-alpha superhelix fold, with the exception of the peptide containing the lysine residue required for SUMO-1 conjugation.","GO:0007165|signal transduction;GO:0046826|negative regulation of protein export from nucleus;GO:0048678|response to axon injury;GO:0071375|cellular response to peptide hormone stimulus;GO:0090630|activation of GTPase activity;GO:1904117|cellular response to vasopressin;","GO:0000776|kinetochore;GO:0005634|nucleus;GO:0005635|nuclear envelope;GO:0005643|nuclear pore;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016235|aggresome;GO:0030425|dendrite;GO:0031965|nuclear membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0044614|nuclear pore cytoplasmic filaments;GO:0048471|perinuclear region of cytoplasm;GO:0072686|mitotic spindle;GO:1904115|axon cytoplasm;GO:1990723|cytoplasmic periphery of the nuclear pore complex;","GO:0003723|RNA binding;GO:0005096|GTPase activator activity;GO:0005515|protein binding;GO:0031267|small GTPase binding;GO:0031625|ubiquitin protein ligase binding;","K14319","RANGAP1; Ran GTPase-activating protein 1"]
["ENSRNOG00000003253",1453,93.47212668,543,35.05708979,2.666283118,1.41482998,{"v":6.75508e-95,"d":"6.76E-95"},{"v":3.82363e-94,"d":"3.82E-94"},"up","yes","Qdpr","protein_coding","chr14:65670131-65683854:+","gi|149047261|gb|EDL99930.1|",1468,0,"quinoid dihydropteridine reductase, isoform CRA_a [Rattus norvegicus]","gi|298903831|emb|FQ213843.1|",1314,0,"Rattus norvegicus TL0AAA45YF05 mRNA sequence","P11348",462,{"v":1e-160,"d":"1.00E-160"},"Dihydropteridine reductase","VNG1540G",70.5,{"v":5e-13,"d":"5.00E-13"},"COG1028","pfam05734","DUF832","Herpesvirus protein of unknown function (DUF832). This family consists of several herpesvirus proteins of unknown function.","GO:0001889|liver development;GO:0006559|L-phenylalanine catabolic process;GO:0006729|tetrahydrobiopterin biosynthetic process;GO:0010044|response to aluminum ion;GO:0010288|response to lead ion;GO:0033762|response to glucagon;GO:0071466|cellular response to xenobiotic stimulus;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0043005|neuron projection;","GO:0004155|6,7-dihydropteridine reductase activity;GO:0042802|identical protein binding;GO:0070402|NADPH binding;GO:0070404|NADH binding;","K00357","QDPR; dihydropteridine reductase [EC:1.5.1.34]"]
["ENSRNOG00000018911",936,60.21329014,247,15.94677933,3.775890346,1.916816869,{"v":2.68029E-94,"d":"2.68E-94"},{"v":1.50817E-93,"d":"1.51E-93"},"up","yes","Pfkfb3","protein_coding","chr17:66983686-67063125:+","gi|635051482|ref|XP_008000388.1|",2488,0,"PREDICTED: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X2 [Chlorocebus sabaeus]","gi|672082363|ref|XM_006254198.2|",1747,0,"PREDICTED: Rattus norvegicus 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (Pfkfb3), transcript variant X8, mRNA","O35552",934,0,"6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3","YJL155c_2",241,{"v":1E-70,"d":"1.00E-70"},"COG0406","pfam01591","6PF2K","6-phosphofructo-2-kinase. This enzyme occurs as a bifunctional enzyme with fructose-2,6-bisphosphatase. The bifunctional enzyme catalyses both the synthesis and degradation of fructose-2,6-bisphosphate, a potent regulator of glycolysis. This enzyme contains a P-loop motif.","GO:0006000|fructose metabolic process;GO:0006003|fructose 2,6-bisphosphate metabolic process;GO:0006110|regulation of glycolytic process;GO:0007420|brain development;GO:0016311|dephosphorylation;GO:0046835|carbohydrate phosphorylation;","GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0003873|6-phosphofructo-2-kinase activity;GO:0004331|fructose-2,6-bisphosphate 2-phosphatase activity;GO:0005524|ATP binding;","K01103","PFKFB3; 6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 3 [EC:2.7.1.105 3.1.3.46]"]
["ENSRNOG00000011984",1275,82.02130869,440,28.40721825,2.887340392,1.529741199,{"v":1.4235E-93,"d":"1.42E-93"},{"v":7.98629e-93,"d":"7.99E-93"},"up","yes","Cxcl14","protein_coding","chr17:8317933-8324839:+","gi|149039826|gb|EDL93942.1|",243,{"v":4e-24,"d":"4.00E-24"},"rCG24136, isoform CRA_b [Rattus norvegicus]","gi|75832148|ref|NM_001013137.2|",370,0,"Rattus norvegicus chemokine (C-X-C motif) ligand 14 (Cxcl14), mRNA","Q9WUQ5",88.2,{"v":1e-21,"d":"1.00E-21"},"C-X-C motif chemokine 14",".",".",".",".","pfam05876","Terminase_GpA","Phage terminase large subunit (GpA). This family consists of several phage terminase large subunit proteins as well as related sequences from several bacterial species. The DNA packaging enzyme of bacteriophage lambda, terminase, is a heteromultimer composed of a small subunit, gpNu1, and a large subunit, gpA, products of the Nu1 and A genes, respectively. Terminase is involved in the site-specific binding and cutting of the DNA in the initial stages of packaging. It is now known that gpA is actively involved in late stages of packaging, including DNA translocation, and that this enzyme contains separate functional domains for its early and late packaging activities.","GO:0007165|signal transduction;GO:0031640|killing of cells of other organism;GO:0045662|negative regulation of myoblast differentiation;GO:0048839|inner ear development;GO:0060326|cell chemotaxis;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:2000503|positive regulation of natural killer cell chemotaxis;","GO:0005615|extracellular space;GO:0005794|Golgi apparatus;","GO:0008009|chemokine activity;","K10033","CXCL14, SCYB14; C-X-C motif chemokine 14"]
["ENSRNOG00000021314",2034,130.8481113,926,59.78428204,2.188670781,1.130054961,{"v":1.43727e-93,"d":"1.44E-93"},{"v":8.05561e-93,"d":"8.06E-93"},"up","yes","Fdft1","protein_coding","chr15:37412146-37440287:-","gi|672078276|ref|XP_008768968.1|",2502,0,"PREDICTED: squalene synthase isoform X1 [Rattus norvegicus]","gi|672078275|ref|XM_008770746.1|",5793,0,"PREDICTED: Rattus norvegicus farnesyl diphosphate farnesyl transferase 1 (Fdft1), transcript variant X1, mRNA","Q02769",801,0,"Squalene synthase","SPBC646.05c",323,{"v":5e-95,"d":"5.00E-95"},"COG1562","pfam00494","SQS_PSY","Squalene/phytoene synthase.","GO:0006695|cholesterol biosynthetic process;GO:0008299|isoprenoid biosynthetic process;GO:0045338|farnesyl diphosphate metabolic process;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0004310|farnesyl-diphosphate farnesyltransferase activity;GO:0046872|metal ion binding;GO:0051996|squalene synthase activity;","K00801","FDFT1; farnesyl-diphosphate farnesyltransferase [EC:2.5.1.21]"]
["ENSRNOG00000021273",2392,153.8784081,1174,75.79562324,2.030175379,1.021604362,{"v":2.21551e-93,"d":"2.22E-93"},{"v":1.24053e-92,"d":"1.24E-92"},"up","yes","Crls1","protein_coding","chr3:120119852-120138655:+","gi|62079247|ref|NP_001014280.1|",1156,{"v":3e-151,"d":"3.00E-151"},"cardiolipin synthase (CMP-forming) [Rattus norvegicus]","gi|62079246|ref|NM_001014258.1|",1870,0,"Rattus norvegicus cardiolipin synthase 1 (Crls1), mRNA","Q5U2V5",449,{"v":1e-152,"d":"1.00E-152"},"Cardiolipin synthase (CMP-forming)","SPAC22A12.08c_2",121,{"v":2e-30,"d":"2.00E-30"},"COG0558","pfam01066","CDP-OH_P_transf","CDP-alcohol phosphatidyltransferase. All of these members have the ability to catalyse the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.","GO:0032049|cardiolipin biosynthetic process;GO:0046474|glycerophospholipid biosynthetic process;GO:0097068|response to thyroxine;GO:1905711|response to phosphatidylethanolamine;","GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0016021|integral component of membrane;GO:0031966|mitochondrial membrane;","GO:0008808|cardiolipin synthase activity;GO:0043337|CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity;","K08744","CRLS; cardiolipin synthase (CMP-forming) [EC:2.7.8.41]"]
["ENSRNOG00000049771",1995,128.3392242,902,58.23479741,2.203823657,1.140008788,{"v":4.35999e-93,"d":"4.36E-93"},{"v":2.43652e-92,"d":"2.44E-92"},"up","yes","Gstt1","protein_coding","chr20:12856669-12873585:+","gi|16757988|ref|NP_445745.1|",1277,{"v":3E-175,"d":"3.00E-175"},"glutathione S-transferase theta-1 [Rattus norvegicus]","gi|55926212|ref|NM_053293.2|",943,0,"Rattus norvegicus glutathione S-transferase theta 1 (Gstt1), mRNA","Q01579",496,{"v":9e-177,"d":"9.00E-177"},"Glutathione S-transferase theta-1","SMb20420",70.9,{"v":1E-13,"d":"1.00E-13"},"COG0625","pfam02798","GST_N","Glutathione S-transferase, N-terminal domain. Function: conjugation of reduced glutathione to a variety of targets. Also included in the alignment, but are not GSTs: * S-crystallins from squid. Similarity to GST previously noted. * Eukaryotic elongation factors 1-gamma. Not known to have GST activity; similarity not previously recognized. * HSP26 family of stress-related proteins. including auxin-regulated proteins in plants and stringent starvation proteins in Escherichia coli. Not known to have GST activity. Similarity not previously recognized. The glutathione molecule binds in a cleft between N and C-terminal domains - the catalytically important residues are proposed to reside in the N-terminal domain.","GO:0006304|DNA modification;GO:0006749|glutathione metabolic process;GO:0007568|aging;GO:0009410|response to xenobiotic stimulus;GO:0009751|response to salicylic acid;GO:0010269|response to selenium ion;GO:0014070|response to organic cyclic compound;GO:0018900|dichloromethane metabolic process;GO:0033197|response to vitamin E;GO:0098869|cellular oxidant detoxification;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004364|glutathione transferase activity;GO:0004602|glutathione peroxidase activity;GO:0047651|alkylhalidase activity;","K00799","GST, gst; glutathione S-transferase [EC:2.5.1.18]"]
["ENSRNOG00000014311",2355,151.4981819,1154,74.50438604,2.03341293,1.023903216,{"v":2.67117E-92,"d":"2.67E-92"},{"v":1.48693e-91,"d":"1.49E-91"},"up","yes","Slc7a8","protein_coding","chr15:28183015-28242717:-","gi|16758188|ref|NP_445894.1|",2472,0,"large neutral amino acids transporter small subunit 2 [Rattus norvegicus]","gi|16758187|ref|NM_053442.1|",4100,0,"Rattus norvegicus solute carrier family 7 (amino acid transporter light chain, L system), member 8 (Slc7a8), mRNA","Q9WVR6",956,0,"Large neutral amino acids transporter small subunit 2","BS_ykbA",139,{"v":1e-33,"d":"1.00E-33"},"COG0531","pfam13520","AA_permease_2","Amino acid permease.","GO:0003333|amino acid transmembrane transport;GO:0006865|amino acid transport;GO:0015695|organic cation transport;GO:0015804|neutral amino acid transport;GO:0015807|L-amino acid transport;GO:0015816|glycine transport;GO:0015820|leucine transport;GO:0015827|tryptophan transport;GO:0015829|valine transport;GO:0035524|proline transmembrane transport;GO:0070327|thyroid hormone transport;GO:0089718|amino acid import across plasma membrane;GO:0098713|leucine import across plasma membrane;GO:1901998|toxin transport;GO:1903801|L-leucine import across plasma membrane;GO:1904273|L-alanine import across plasma membrane;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0009925|basal plasma membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0031528|microvillus membrane;","GO:0015101|organic cation transmembrane transporter activity;GO:0015171|amino acid transmembrane transporter activity;GO:0015175|neutral amino acid transmembrane transporter activity;GO:0015179|L-amino acid transmembrane transporter activity;GO:0015180|L-alanine transmembrane transporter activity;GO:0015187|glycine transmembrane transporter activity;GO:0015190|L-leucine transmembrane transporter activity;GO:0015349|thyroid hormone transmembrane transporter activity;GO:0019534|toxin transmembrane transporter activity;GO:0042605|peptide antigen binding;","K13781","SLC7A8, LAT2; solute carrier family 7 (L-type amino acid transporter), member 8"]
["ENSRNOG00000000167",547,35.18874969,69,4.454768316,7.899120042,2.981691947,{"v":3.10344e-92,"d":"3.10E-92"},{"v":1.72419e-91,"d":"1.72E-91"},"up","yes","ENSRNOG00000000167","protein_coding","chrX:19463171-19486519:+","gi|51980582|gb|AAH81857.1|",3064,0,"Aminolevulinate, delta-, synthase 2 [Rattus norvegicus]","gi|156255175|ref|NM_001102446.1|",1674,0,"Mus musculus aminolevulinic acid synthase 2, erythroid (Alas2), transcript variant 2, mRNA","Q63147",1183,0,"5-aminolevulinate synthase, erythroid-specific, mitochondrial","AGc4738",412,{"v":2E-136,"d":"2.00E-136"},"COG0156","pfam00155","Aminotran_1_2","Aminotransferase class I and II.","GO:0001666|response to hypoxia;GO:0006782|protoporphyrinogen IX biosynthetic process;GO:0006783|heme biosynthetic process;GO:0006879|cellular iron ion homeostasis;GO:0007595|lactation;GO:0009410|response to xenobiotic stimulus;GO:0010288|response to lead ion;GO:0030218|erythrocyte differentiation;GO:0032025|response to cobalt ion;GO:0042541|hemoglobin biosynthetic process;GO:0048821|erythrocyte development;GO:0060135|maternal process involved in female pregnancy;GO:0070542|response to fatty acid;GO:0097421|liver regeneration;GO:1901423|response to benzene;","GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0005759|mitochondrial matrix;","GO:0003870|5-aminolevulinate synthase activity;GO:0030170|pyridoxal phosphate binding;","K00643","E2.3.1.37, ALAS; 5-aminolevulinate synthase [EC:2.3.1.37]"]
["ENSRNOG00000018689",1823,117.2743888,792,51.13299285,2.293517009,1.197561607,{"v":4.92126e-92,"d":"4.92E-92"},{"v":2.72617e-91,"d":"2.73E-91"},"up","yes","RGD1305464","protein_coding","chr8:57645756-57655941:-","gi|212549544|ref|NP_001020182.2|",4208,0,"uncharacterized protein LOC315702 [Rattus norvegicus]","gi|212549543|ref|NM_001025011.2|",2964,0,"Rattus norvegicus similar to human chromosome 15 open reading frame 39 (RGD1305464), mRNA","Q3TEI4",1477,0,"Uncharacterized protein C15orf39 homolog",".",".",".",".","pfam15319","RHINO","RAD9, RAD1, HUS1-interacting nuclear orphan protein. RHINO, or RAD9, RAD1, HUS1-interacting nuclear orphan, is a family of eukaryotic proteins. Under genotoxic stresses such as ionizing radiation during the S phase, RHINO plays a role in DNA damage response signalling. It is recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent (ataxia telangiectasia and Rad3-related) manner. It is required for the progression of the G1 to S phase transition of breast cancer cells, and it is known to play a role in the stimulation of CHEK1 phosphorylation. It interacts with RAD9A, RAD18, TOPBP1 and UBE2N.",".","GO:0005829|cytosol;",".",".","."]
["ENSRNOG00000021380",657,42.26509789,116,7.48917572,5.643491282,2.496587946,{"v":6.78325e-92,"d":"6.78E-92"},{"v":3.754e-91,"d":"3.75E-91"},"up","yes","Fads6","protein_coding","chr10:100522981-100538181:-","gi|157818323|ref|NP_001100534.1|",1622,0,"fatty acid desaturase 6 [Rattus norvegicus]","gi|157818322|ref|NM_001107064.1|",1796,0,"Rattus norvegicus fatty acid desaturase 6 (Fads6), mRNA","Q80UG1",590,0,"Fatty acid desaturase 6",".",".",".",".","pfam00487","FA_desaturase","Fatty acid desaturase.","GO:0006629|lipid metabolic process;","GO:0016021|integral component of membrane;","GO:0016717|oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water;","K12419","FADS6; fatty acid desaturase 6 [EC:1.14.19.-]"]
["ENSRNOG00000012443",1163,74.81629961,381,24.59806853,3.0415518,1.604807575,{"v":1.45058e-91,"d":"1.45E-91"},{"v":8.00456e-91,"d":"8.00E-91"},"up","yes","Cpt2","protein_coding","chr5:122664677-122682095:-","gi|149035736|gb|EDL90417.1|",3558,0,"carnitine palmitoyltransferase 2 [Rattus norvegicus]","gi|6978704|ref|NM_012930.1|",2121,0,"Rattus norvegicus carnitine palmitoyltransferase 2 (Cpt2), mRNA","P18886",1368,0,"Carnitine O-palmitoyltransferase 2, mitochondrial",".",".",".",".","pfam00755","Carn_acyltransf","Choline/Carnitine o-acyltransferase.","GO:0001676|long-chain fatty acid metabolic process;GO:0001701|in utero embryonic development;GO:0006635|fatty acid beta-oxidation;GO:0009437|carnitine metabolic process;GO:0015909|long-chain fatty acid transport;GO:0070542|response to fatty acid;GO:0120162|positive regulation of cold-induced thermogenesis;","GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;","GO:0004095|carnitine O-palmitoyltransferase activity;GO:0008458|carnitine O-octanoyltransferase activity;GO:0016746|transferase activity, transferring acyl groups;","K08766","CPT2; carnitine O-palmitoyltransferase 2 [EC:2.3.1.21]"]
["ENSRNOG00000008843",1840,118.3680063,806,52.03685888,2.274695452,1.185673403,{"v":1.90726E-91,"d":"1.91E-91"},{"v":1.05043e-90,"d":"1.05E-90"},"up","yes","Eci1","protein_coding","chr10:13456563-13470061:+","gi|162287040|ref|NP_059002.2|",1478,0,"enoyl-CoA delta isomerase 1, mitochondrial precursor [Rattus norvegicus]","gi|298916079|emb|FQ213384.1|",968,0,"Rattus norvegicus TL0AAA48YC13 mRNA sequence","P23965",570,0,"Enoyl-CoA delta isomerase 1, mitochondrial","CAC2712",92.8,{"v":7e-21,"d":"7.00E-21"},"COG1024","pfam00378","ECH","Enoyl-CoA hydratase/isomerase family. This family contains a diverse set of enzymes including: Enoyl-CoA hydratase. Napthoate synthase. Carnitate racemase. 3-hydoxybutyryl-CoA dehydratase. Dodecanoyl-CoA delta-isomerase.","GO:0006635|fatty acid beta-oxidation;","GO:0005739|mitochondrion;GO:0005759|mitochondrial matrix;","GO:0003824|catalytic activity;GO:0004165|dodecenoyl-CoA delta-isomerase activity;GO:0004300|enoyl-CoA hydratase activity;GO:0016863|intramolecular oxidoreductase activity, transposing C=C bonds;GO:0042802|identical protein binding;","K13238","ECI1, DCI; Delta3-Delta2-enoyl-CoA isomerase [EC:5.3.3.8]"]
["ENSRNOG00000007152",2081,133.8716419,969,62.56044201,2.139876855,1.097527775,{"v":2.2754E-91,"d":"2.28E-91"},{"v":1.25077e-90,"d":"1.25E-90"},"up","yes","Bhlhe40","protein_coding","chr4:141618476-141624774:+","gi|744579291|ref|XP_010983292.1|",1906,0,"PREDICTED: class E basic helix-loop-helix protein 40 [Camelus dromedarius]","gi|16758031|ref|NM_053328.1|",2314,0,"Rattus norvegicus basic helix-loop-helix family, member e40 (Bhlhe40), mRNA","O35780",729,0,"Class E basic helix-loop-helix protein 40",".",".",".",".","pfam00010","HLH","Helix-loop-helix DNA-binding domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007399|nervous system development;GO:0007623|circadian rhythm;GO:0009416|response to light stimulus;GO:0009952|anterior/posterior pattern specification;GO:0032922|circadian regulation of gene expression;GO:0042752|regulation of circadian rhythm;GO:0043153|entrainment of circadian clock by photoperiod;GO:0043433|negative regulation of DNA-binding transcription factor activity;GO:0045892|negative regulation of transcription, DNA-templated;GO:0048168|regulation of neuronal synaptic plasticity;GO:0050767|regulation of neurogenesis;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0016604|nuclear body;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0019904|protein domain specific binding;GO:0042803|protein homodimerization activity;GO:0043425|bHLH transcription factor binding;GO:0043426|MRF binding;GO:0046982|protein heterodimerization activity;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;GO:0070888|E-box binding;GO:1990837|sequence-specific double-stranded DNA binding;","K03729","BHLHB2, DEC1; class B basic helix-loop-helix protein 2"]
["ENSRNOG00000008931",613,39.43455861,99,6.391624106,6.169724307,2.625206024,{"v":1.07543E-90,"d":"1.08E-90"},{"v":5.88326e-90,"d":"5.88E-90"},"up","yes","Slc25a21","protein_coding","chr6:74203440-74702680:-","gi|19424330|ref|NP_598298.1|",1580,0,"mitochondrial 2-oxodicarboxylate carrier [Rattus norvegicus]","gi|58037555|ref|NM_133614.2|",2437,0,"Rattus norvegicus solute carrier family 25 member 21 (Slc25a21), mRNA","Q99JD3",613,0,"Mitochondrial 2-oxodicarboxylate carrier",".",".",".",".","pfam00153","Mito_carr","Mitochondrial carrier protein.","GO:1990550|mitochondrial alpha-ketoglutarate transmembrane transport;","GO:0005743|mitochondrial inner membrane;GO:0016021|integral component of membrane;","GO:0015139|alpha-ketoglutarate transmembrane transporter activity;","K15110","SLC25A21, ODC; solute carrier family 25 (mitochondrial 2-oxodicarboxylate transporter), member 21"]
["ENSRNOG00000015641",2381,153.1707733,1182,76.31211811,2.007161865,1.005156966,{"v":1.4796e-90,"d":"1.48E-90"},{"v":8.08658e-90,"d":"8.09E-90"},"up","yes","Exoc3l1","pseudogene","chr19:33166837-33172486:-","gi|157818407|ref|NP_001099648.1|",3075,0,"exocyst complex component 3-like protein [Rattus norvegicus]","gi|157818406|ref|NM_001106178.1|",2511,0,"Rattus norvegicus exocyst complex component 3-like 1 (Exoc3l1), mRNA","Q8BI71",1091,0,"Exocyst complex component 3-like protein",".",".",".",".","pfam06046","Sec6","Exocyst complex component Sec6. Sec6 is a component of the multiprotein exocyst complex. Sec6 interacts with Sec8, Sec10 and Exo70.These exocyst proteins localize to regions of active exocytosis-at the growing ends of interphase cells and in the medial region of cells undergoing cytokinesis-in an F-actin-dependent and exocytosis- independent manner.","GO:0006887|exocytosis;GO:0030072|peptide hormone secretion;GO:0051601|exocyst localization;","GO:0000145|exocyst;GO:0030141|secretory granule;","GO:0000149|SNARE binding;","K19987","EXOC3L1; exocyst complex component 3-like protein"]
["ENSRNOG00000017513",1886,121.3272064,845,54.55477141,2.223952246,1.15312581,{"v":1.06255E-89,"d":"1.06E-89"},{"v":5.77407e-89,"d":"5.77E-89"},"up","yes","Miga2","protein_coding","chr3:13636238-13658896:+","gi|74178322|dbj|BAE32434.1|",3006,0,"unnamed protein product [Mus musculus]","gi|564339950|ref|XM_006233781.1|",3419,0,"PREDICTED: Rattus norvegicus family with sequence similarity 73, member B (Fam73b), transcript variant X1, mRNA","Q8BK03",1058,0,"Mitoguardin 2",".",".",".",".","pfam10265","DUF2217","Uncharacterized conserved protein (DUF2217). This is a family of conserved proteins of from 500 - 600 residues found from worms to humans. Its function is not known.","GO:0008053|mitochondrial fusion;GO:0060348|bone development;","GO:0005739|mitochondrion;GO:0005887|integral component of plasma membrane;","GO:0042803|protein homodimerization activity;GO:0046982|protein heterodimerization activity;",".","."]
["ENSRNOG00000003969",1439,92.57150055,558,36.02551769,2.569609168,1.361548946,{"v":8.73085e-89,"d":"8.73E-89"},{"v":4.69093e-88,"d":"4.69E-88"},"up","yes","Fam20a","protein_coding","chr10:94642850-94697672:-","gi|59676595|ref|NP_001012237.1|",2778,0,"protein FAM20A [Rattus norvegicus]","gi|755537910|ref|XR_388388.2|",2019,0,"PREDICTED: Mus musculus family with sequence similarity 20, member A (Fam20a), transcript variant X2, misc_RNA","Q8CID3",996,0,"Pseudokinase FAM20A",".",".",".",".","pfam06702","DUF1193","Protein of unknown function (DUF1193). This family represents the C-terminus of several hypothetical eukaryotic proteins of unknown function. Family members contain two conserved motifs: DRHHYE and QCC, as well as a number of conserved cysteine residues.","GO:0001934|positive regulation of protein phosphorylation;GO:0009617|response to bacterium;GO:0031214|biomineral tissue development;GO:0044691|tooth eruption;GO:0055074|calcium ion homeostasis;GO:0070166|enamel mineralization;GO:0071902|positive regulation of protein serine/threonine kinase activity;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;","GO:0043539|protein serine/threonine kinase activator activity;","K21957","FAM20A; pseudokinase FAM20A"]
["ENSRNOG00000002403",1758,113.0929103,768,49.58350822,2.280857374,1.189576235,{"v":6.65458e-88,"d":"6.65E-88"},{"v":3.54868e-87,"d":"3.55E-87"},"up","yes","Niban1","protein_coding","chr13:63674171-63827729:+","gi|257471021|ref|NP_071578.2|",4876,0,"protein Niban [Rattus norvegicus]","gi|15011896|ref|NM_022242.2|",3628,0,"Rattus norvegicus family with sequence similarity 129, member A (Fam129a), mRNA","Q9ESN0",1882,0,"Protein Niban",".",".",".",".","pfam05701","WEMBL","Weak chloroplast movement under blue light. WEMBL consists of several plant proteins required for the chloroplast avoidance response under high intensity blue light. This avoidance response consists in the relocation of chloroplasts on the anticlinal side of exposed cells. Acts in association with PMI2 to maintain the velocity of chloroplast photo-relocation movement via the regulation of cp-actin filaments. Thus several member-sequences are described as \"myosin heavy chain-like\".","GO:0001933|negative regulation of protein phosphorylation;GO:0001934|positive regulation of protein phosphorylation;GO:0034976|response to endoplasmic reticulum stress;GO:0045727|positive regulation of translation;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0003674|molecular_function;",".","."]
["ENSRNOG00000016122",1803,115.98778,798,51.520364,2.2512997,1.170758126,{"v":6.77668e-88,"d":"6.78E-88"},{"v":3.61042e-87,"d":"3.61E-87"},"up","yes","Hmgcr","protein_coding","chr2:27997525-28019703:-","gi|564334920|ref|XP_006231888.1|",4528,0,"PREDICTED: 3-hydroxy-3-methylglutaryl-coenzyme A reductase isoform X1 [Rattus norvegicus]","gi|672041189|ref|XM_006231826.2|",4280,0,"PREDICTED: Rattus norvegicus 3-hydroxy-3-methylglutaryl-CoA reductase (Hmgcr), transcript variant X1, mRNA","P51639",1733,0,"3-hydroxy-3-methylglutaryl-coenzyme A reductase","YML075c",504,{"v":2e-152,"d":"2.00E-152"},"COG1257","pfam00368","HMG-CoA_red","Hydroxymethylglutaryl-coenzyme A reductase. The HMG-CoA reductases catalyse the conversion of HMG-CoA to mevalonate, which is the rate-limiting step in the synthesis of isoprenoids like cholesterol. Probably because of the critical role of this enzyme in cholesterol homeostasis, mammalian HMG-CoA reductase is heavily regulated at the transcriptional, translational, and post-translational levels.","GO:0006695|cholesterol biosynthetic process;GO:0006743|ubiquinone metabolic process;GO:0007568|aging;GO:0007584|response to nutrient;GO:0008284|positive regulation of cell proliferation;GO:0008299|isoprenoid biosynthetic process;GO:0008542|visual learning;GO:0010664|negative regulation of striated muscle cell apoptotic process;GO:0010666|positive regulation of cardiac muscle cell apoptotic process;GO:0015936|coenzyme A metabolic process;GO:0016126|sterol biosynthetic process;GO:0031667|response to nutrient levels;GO:0032874|positive regulation of stress-activated MAPK cascade;GO:0038183|bile acid signaling pathway;GO:0042177|negative regulation of protein catabolic process;GO:0042632|cholesterol homeostasis;GO:0043066|negative regulation of apoptotic process;GO:0043407|negative regulation of MAP kinase activity;GO:0045445|myoblast differentiation;GO:0045471|response to ethanol;GO:0045907|positive regulation of vasoconstriction;GO:0048643|positive regulation of skeletal muscle tissue development;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0050709|negative regulation of protein secretion;GO:0061045|negative regulation of wound healing;GO:0061179|negative regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0070328|triglyceride homeostasis;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070723|response to cholesterol;GO:1900222|negative regulation of amyloid-beta clearance;","GO:0005778|peroxisomal membrane;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0004420|hydroxymethylglutaryl-CoA reductase (NADPH) activity;GO:0042802|identical protein binding;GO:0051721|protein phosphatase 2A binding;GO:0070402|NADPH binding;","K00021","HMGCR; hydroxymethylglutaryl-CoA reductase (NADPH) [EC:1.1.1.34]"]
["ENSRNOG00000008048",1193,76.74621275,411,26.53492432,2.892271779,1.532203125,{"v":7.00863e-88,"d":"7.01E-88"},{"v":3.73052e-87,"d":"3.73E-87"},"up","yes","Plscr2","protein_coding","chr8:92784356-92804692:+","gi|17105346|ref|NP_476542.1|",1291,{"v":1E-172,"d":"1.00E-172"},"phospholipid scramblase 1 [Rattus norvegicus]","gi|17105345|ref|NM_057194.1|",1536,0,"Rattus norvegicus phospholipid scramblase 1 (Plscr1), mRNA","P58195",501,{"v":3e-174,"d":"3.00E-174"},"Phospholipid scramblase 1",".",".",".",".","pfam03803","Scramblase","Scramblase. Scramblase is palmitoylated and contains a potential protein kinase C phosphorylation site. Scramblase exhibits Ca2+-activated phospholipid scrambling activity in vitro. There are also possible SH3 and WW binding motifs. Scramblase is involved in the redistribution of phospholipids after cell activation or injury.","GO:0006659|phosphatidylserine biosynthetic process;GO:0006915|apoptotic process;GO:0006953|acute-phase response;GO:0006955|immune response;GO:0010288|response to lead ion;GO:0010628|positive regulation of gene expression;GO:0015914|phospholipid transport;GO:0017121|phospholipid scrambling;GO:0030099|myeloid cell differentiation;GO:0032091|negative regulation of protein binding;GO:0033003|regulation of mast cell activation;GO:0035455|response to interferon-alpha;GO:0035456|response to interferon-beta;GO:0043065|positive regulation of apoptotic process;GO:0045071|negative regulation of viral genome replication;GO:0045089|positive regulation of innate immune response;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046718|viral entry into host cell;GO:0050765|negative regulation of phagocytosis;GO:0051607|defense response to virus;GO:0060368|regulation of Fc receptor mediated stimulatory signaling pathway;GO:0070782|phosphatidylserine exposure on apoptotic cell surface;GO:0071222|cellular response to lipopolysaccharide;GO:0071345|cellular response to cytokine stimulus;GO:0090305|nucleic acid phosphodiester bond hydrolysis;GO:0097193|intrinsic apoptotic signaling pathway;GO:1902231|positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:1905820|positive regulation of chromosome separation;GO:2000373|positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0045121|membrane raft;GO:0048471|perinuclear region of cytoplasm;GO:0062023|collagen-containing extracellular matrix;","GO:0000287|magnesium ion binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0001618|virus receptor activity;GO:0003677|DNA binding;GO:0004518|nuclease activity;GO:0005154|epidermal growth factor receptor binding;GO:0005509|calcium ion binding;GO:0008270|zinc ion binding;GO:0017124|SH3 domain binding;GO:0017128|phospholipid scramblase activity;GO:0019899|enzyme binding;GO:0032791|lead ion binding;GO:0042609|CD4 receptor binding;GO:0045340|mercury ion binding;",".","."]
["ENSRNOG00000022937",469,30.17097551,46,2.969845544,10.15910594,3.344701537,{"v":7.70979e-88,"d":"7.71E-88"},{"v":4.09991e-87,"d":"4.10E-87"},"up","yes","Bpifc","protein_coding","chr7:17861007-17905919:+","gi|157818469|ref|NP_001100243.1|",2684,0,"BPI fold-containing family C protein precursor [Rattus norvegicus]","gi|157818468|ref|NM_001106773.1|",2158,0,"Rattus norvegicus BPI fold containing family C (Bpifc), mRNA","Q8C186",945,0,"BPI fold-containing family C protein",".",".",".",".","pfam01273","LBP_BPI_CETP","LBP / BPI / CETP family, N-terminal domain. The N and C terminal domains of the LBP/BPI/CETP family are structurally similar.",".","GO:0005615|extracellular space;","GO:0008289|lipid binding;","K25377","BPIFC; BPI fold-containing family C"]
["ENSRNOG00000014850",1368,88.00403944,518,33.4430433,2.63146026,1.395863608,{"v":1.09299e-87,"d":"1.09E-87"},{"v":5.79612e-87,"d":"5.80E-87"},"up","yes","Amhr2","protein_coding","chr7:133579393-133588258:+","gi|453178|emb|CAA50731.1|",2310,0,"put. anti-mullerian hormone receptor [Rattus norvegicus]","gi|13591889|ref|NM_030998.1|",1920,0,"Rattus norvegicus anti-Mullerian hormone receptor, type II (Amhr2), mRNA","Q62893",894,0,"Anti-Muellerian hormone type-2 receptor",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006468|protein phosphorylation;GO:0007178|transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0007548|sex differentiation;GO:0008584|male gonad development;GO:0008585|female gonad development;GO:0032924|activin receptor signaling pathway;GO:0071363|cellular response to growth factor stimulus;GO:1902613|negative regulation of anti-Mullerian hormone signaling pathway;GO:1990262|anti-Mullerian hormone signaling pathway;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;GO:0043235|receptor complex;GO:0048179|activin receptor complex;","GO:0004674|protein serine/threonine kinase activity;GO:0004675|transmembrane receptor protein serine/threonine kinase activity;GO:0005026|transforming growth factor beta receptor activity, type II;GO:0005524|ATP binding;GO:0017002|activin-activated receptor activity;GO:0042562|hormone binding;GO:0046872|metal ion binding;GO:0048185|activin binding;GO:1990272|anti-Mullerian hormone receptor activity;","K04672","AMHR2; anti-mullerian hormone receptor type-2 [EC:2.7.11.30]"]
["ENSRNOG00000059890",789,50.75671573,190,12.26675333,4.137746504,2.048845262,{"v":6.60364e-87,"d":"6.60E-87"},{"v":3.47928e-86,"d":"3.48E-86"},"up","yes","Clec2d2","protein_coding","chr4:162059008-162071088:-","gi|145966769|ref|NP_001078871.1|",1061,{"v":2e-133,"d":"2.00E-133"},"C-type lectin domain family 2 member D2 [Rattus norvegicus]","gi|298904485|emb|FQ221935.1|",3091,0,"Rattus norvegicus TL0ADA2YO07 mRNA sequence","A4KWA5",413,{"v":6e-135,"d":"6.00E-135"},"C-type lectin domain family 2 member D2",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type",".","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0030246|carbohydrate binding;GO:0046703|natural killer cell lectin-like receptor binding;",".","."]
["ENSRNOG00000046829",2176,139.9830335,1060,68.43557123,2.045471835,1.032433672,{"v":1.41559e-86,"d":"1.42E-86"},{"v":7.43094e-86,"d":"7.43E-86"},"up","yes","Kdr","protein_coding","chr14:32217871-32261018:+","gi|56269800|gb|AAH87029.1|",6778,0,"Kdr protein [Rattus norvegicus]","gi|56269799|gb|BC087029.1|",5484,0,"Rattus norvegicus kinase insert domain protein receptor, mRNA (cDNA clone MGC:93590 IMAGE:7124961), complete cds","O08775",2591,0,"Vascular endothelial growth factor receptor 2",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001525|angiogenesis;GO:0001541|ovarian follicle development;GO:0001569|branching involved in blood vessel morphogenesis;GO:0001570|vasculogenesis;GO:0001666|response to hypoxia;GO:0001934|positive regulation of protein phosphorylation;GO:0001938|positive regulation of endothelial cell proliferation;GO:0001945|lymph vessel development;GO:0002042|cell migration involved in sprouting angiogenesis;GO:0002053|positive regulation of mesenchymal cell proliferation;GO:0002244|hematopoietic progenitor cell differentiation;GO:0003085|negative regulation of systemic arterial blood pressure;GO:0003157|endocardium development;GO:0003158|endothelium development;GO:0003416|endochondral bone growth;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007275|multicellular organism development;GO:0007568|aging;GO:0008284|positive regulation of cell proliferation;GO:0008360|regulation of cell shape;GO:0008584|male gonad development;GO:0009410|response to xenobiotic stimulus;GO:0010595|positive regulation of endothelial cell migration;GO:0010629|negative regulation of gene expression;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0016239|positive regulation of macroautophagy;GO:0016477|cell migration;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0030097|hemopoiesis;GO:0030324|lung development;GO:0030335|positive regulation of cell migration;GO:0030513|positive regulation of BMP signaling pathway;GO:0032008|positive regulation of TOR signaling;GO:0033674|positive regulation of kinase activity;GO:0035162|embryonic hemopoiesis;GO:0035584|calcium-mediated signaling using intracellular calcium source;GO:0035924|cellular response to vascular endothelial growth factor stimulus;GO:0036324|vascular endothelial growth factor receptor-2 signaling pathway;GO:0038033|positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway;GO:0038083|peptidyl-tyrosine autophosphorylation;GO:0038084|vascular endothelial growth factor signaling pathway;GO:0042311|vasodilation;GO:0043066|negative regulation of apoptotic process;GO:0043129|surfactant homeostasis;GO:0043410|positive regulation of MAPK cascade;GO:0043491|protein kinase B signaling;GO:0043524|negative regulation of neuron apoptotic process;GO:0043536|positive regulation of blood vessel endothelial cell migration;GO:0045165|cell fate commitment;GO:0045446|endothelial cell differentiation;GO:0045766|positive regulation of angiogenesis;GO:0046777|protein autophosphorylation;GO:0048010|vascular endothelial growth factor receptor signaling pathway;GO:0048170|positive regulation of long-term neuronal synaptic plasticity;GO:0048286|lung alveolus development;GO:0048469|cell maturation;GO:0048597|post-embryonic camera-type eye morphogenesis;GO:0048754|branching morphogenesis of an epithelial tube;GO:0048812|neuron projection morphogenesis;GO:0050679|positive regulation of epithelial cell proliferation;GO:0050769|positive regulation of neurogenesis;GO:0050850|positive regulation of calcium-mediated signaling;GO:0050927|positive regulation of positive chemotaxis;GO:0051770|positive regulation of nitric-oxide synthase biosynthetic process;GO:0051894|positive regulation of focal adhesion assembly;GO:0051901|positive regulation of mitochondrial depolarization;GO:0055074|calcium ion homeostasis;GO:0061042|vascular wound healing;GO:0061154|endothelial tube morphogenesis;GO:0070371|ERK1 and ERK2 cascade;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070482|response to oxygen levels;GO:0090050|positive regulation of cell migration involved in sprouting angiogenesis;GO:0090141|positive regulation of mitochondrial fission;GO:1901532|regulation of hematopoietic progenitor cell differentiation;GO:1903010|regulation of bone development;GO:1904881|cellular response to hydrogen sulfide;GO:2000352|negative regulation of endothelial cell apoptotic process;GO:2001214|positive regulation of vasculogenesis;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005769|early endosome;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0030054|cell junction;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043235|receptor complex;GO:0045121|membrane raft;GO:0071944|cell periphery;GO:0097443|sorting endosome;","GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0005021|vascular endothelial growth factor-activated receptor activity;GO:0005178|integrin binding;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0019838|growth factor binding;GO:0038085|vascular endothelial growth factor binding;GO:0042802|identical protein binding;GO:0045296|cadherin binding;","K05098","KDR, VEGFR2, CD309; kinase insert domain protein receptor [EC:2.7.10.1]"]
["ENSRNOG00000068800",1721,110.7126841,750,48.42139474,2.286441452,1.193103977,{"v":1.72437e-86,"d":"1.72E-86"},{"v":9.04351e-86,"d":"9.04E-86"},"up","yes","ENSRNOG00000068800","lncRNA","chr1:121835476-121838547:+",".",".",".",".","gi|672036987|ref|XM_006229324.2|",3072,0,"PREDICTED: Rattus norvegicus insulin-like growth factor 1 receptor (Igf1r), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam02354","Latrophilin","Latrophilin Cytoplasmic C-terminal region. This family consists of the cytoplasmic C-terminal region in latrophilin. Latrophilin is a synaptic Ca2+ independent alpha- latrotoxin (LTX) receptor and is a novel member of the secretin family of G-protein coupled receptors that are involved in secretion. Latrophilin mRNA is present only in neuronal tissue. Lactrophillin interacts with G-alpha O.",".",".",".",".","."]
["ENSRNOG00000007546",829,53.32993326,212,13.68711425,3.896360642,1.962127218,{"v":2.57862E-86,"d":"2.58E-86"},{"v":1.35113e-85,"d":"1.35E-85"},"up","yes","Asns","protein_coding","chr4:35785237-35803423:-","gi|149064973|gb|EDM15049.1|",2902,0,"asparagine synthetase, isoform CRA_a [Rattus norvegicus]","gi|672048825|ref|XM_006236089.2|",2426,0,"PREDICTED: Rattus norvegicus asparagine synthetase (glutamine-hydrolyzing) (Asns), transcript variant X1, mRNA","P49088",1106,0,"Asparagine synthetase [glutamine-hydrolyzing]","L00396",330,{"v":9E-102,"d":"9.00E-102"},"COG0367","pfam00733","Asn_synthase","Asparagine synthase. This family is always found associated with pfam00310. Members of this family catalyse the conversion of aspartate to asparagine.","GO:0001889|liver development;GO:0006520|cellular amino acid metabolic process;GO:0006529|asparagine biosynthetic process;GO:0006541|glutamine metabolic process;GO:0009416|response to light stimulus;GO:0009612|response to mechanical stimulus;GO:0009636|response to toxic substance;GO:0031427|response to methotrexate;GO:0031667|response to nutrient levels;GO:0032354|response to follicle-stimulating hormone;GO:0032870|cellular response to hormone stimulus;GO:0042149|cellular response to glucose starvation;GO:0043066|negative regulation of apoptotic process;GO:0043200|response to amino acid;GO:0045931|positive regulation of mitotic cell cycle;GO:0070981|L-asparagine biosynthetic process;","GO:0005829|cytosol;","GO:0004066|asparagine synthase (glutamine-hydrolyzing) activity;GO:0005524|ATP binding;GO:0042802|identical protein binding;","K01953","asnB, ASNS; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4]"]
["ENSRNOG00000016066",1418,91.22056135,555,35.83183211,2.545796739,1.348117237,{"v":3.14865E-86,"d":"3.15E-86"},{"v":1.6483e-85,"d":"1.65E-85"},"up","yes","Bambi","protein_coding","chr17:54121255-54126060:-","gi|20806113|ref|NP_620782.1|",1167,{"v":1e-154,"d":"1.00E-154"},"BMP and activin membrane-bound inhibitor homolog precursor [Rattus norvegicus]","gi|47124146|gb|BC070516.1|",1060,0,"Rattus norvegicus BMP and activin membrane-bound inhibitor, homolog (Xenopus laevis), mRNA (cDNA clone MGC:91477 IMAGE:7100920), complete cds","Q91XN4",454,{"v":4e-156,"d":"4.00E-156"},"BMP and activin membrane-bound inhibitor homolog",".",".",".",".","pfam06211","BAMBI","BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain. This family consists of several eukaryotic BMP and activin membrane-bound inhibitor (BAMBI) proteins. Members of the transforming growth factor-beta (TGF-beta) superfamily, including TGF-beta, bone morphogenetic proteins (BMPs), activins and nodals, are vital for regulating growth and differentiation. BAMBI is related to TGF-beta-family type I receptors but lacks an intracellular kinase domain. BAMBI is co-expressed with the ventralising morphogen BMP4 during Xenopus embryogenesis and requires BMP signalling for its expression. The protein stably associates with TGF-beta-family receptors and inhibits BMP and activin as well as TGF-beta signalling.","GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0008284|positive regulation of cell proliferation;GO:0008360|regulation of cell shape;GO:0010718|positive regulation of epithelial to mesenchymal transition;GO:0016477|cell migration;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030514|negative regulation of BMP signaling pathway;GO:0032092|positive regulation of protein binding;GO:0045668|negative regulation of osteoblast differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0090263|positive regulation of canonical Wnt signaling pathway;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0005109|frizzled binding;","K10162","BAMBI; BMP and activin membrane-bound inhibitor"]
["ENSRNOG00000018051",1287,82.79327394,474,30.60232148,2.705457297,1.43587247,{"v":3.99482e-86,"d":"3.99E-86"},{"v":2.08743E-85,"d":"2.09E-85"},"up","yes","Farp2","protein_coding","chr9:94053726-94162212:+","gi|537217423|gb|ERE82032.1|",3165,0,"FERM, RhoGEF and pleckstrin domain-containing protein 2 [Cricetulus griseus]","gi|26103702|dbj|AK086699.1|",2125,0,"Mus musculus 15 days embryo head cDNA, RIKEN full-length enriched library, clone:D930046G03 product:hypothetical Serine-rich region/Band 4.1 family containing protein, full insert sequence","Q91VS8",763,0,"FERM, ARHGEF and pleckstrin domain-containing protein 2",".",".",".",".","pfam09380","FERM_C","FERM C-terminal PH-like domain.","GO:0007155|cell adhesion;GO:0016322|neuron remodeling;GO:0016601|Rac protein signal transduction;GO:0022405|hair cycle process;GO:0030316|osteoclast differentiation;GO:0031532|actin cytoskeleton reorganization;GO:0033623|regulation of integrin activation;GO:0050790|regulation of catalytic activity;GO:0071526|semaphorin-plexin signaling pathway;GO:0071800|podosome assembly;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0008092|cytoskeletal protein binding;","K06082","FARP2, FRG; FERM, RhoGEF and pleckstrin domain protein 2"]
["ENSRNOG00000017165",1038,66.77499484,328,21.17628997,3.153290541,1.656858104,{"v":1.11733E-85,"d":"1.12E-85"},{"v":5.80658e-85,"d":"5.81E-85"},"up","yes","Akr1e2","protein_coding","chr17:65735943-65750441:+","gi|56605762|ref|NP_001008343.1|",1612,0,"1,5-anhydro-D-fructose reductase [Rattus norvegicus]","gi|56605761|ref|NM_001008342.1|",1340,0,"Rattus norvegicus aldo-keto reductase family 1, member E2 (Akr1e2), mRNA","Q5U1Y4",625,0,"1,5-anhydro-D-fructose reductase","slr0942",223,{"v":3e-67,"d":"3.00E-67"},"COG0656","pfam00248","Aldo_ket_red","Aldo/keto reductase family. This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.",".","GO:0005829|cytosol;","GO:0004032|alditol:NADP+ 1-oxidoreductase activity;GO:0016491|oxidoreductase activity;GO:0047834|D-threo-aldose 1-dehydrogenase activity;GO:0050571|1,5-anhydro-D-fructose reductase activity;","K13981","AKR1E2, AKR1CL2; 1,5-anhydro-D-fructose reductase [EC:1.1.1.263]"]
["ENSRNOG00000068605",1866,120.0405977,852,55.00670443,2.182290303,1.125843031,{"v":1.7076E-85,"d":"1.71E-85"},{"v":8.858e-85,"d":"8.86E-85"},"up","yes","ENSRNOG00000068605","protein_coding","chr1:7387083-7395497:+","gi|148676020|gb|EDL07967.1|",1100,{"v":9e-135,"d":"9.00E-135"},"mCG1029965 [Mus musculus]","gi|46240867|gb|AC107531.8|",2360,0,"Rattus norvegicus 1 BAC CH230-158N3 (Children's Hospital Oakland Research Institute) complete sequence","P31789",197,{"v":3E-52,"d":"3.00E-52"},"Envelope glycoprotein",".",".",".",".","pfam11822","DUF3342","Domain of unknown function (DUF3342). This family of proteins are functionally uncharacterized. This family is found in bacteria. This presumed domain is typically between 170 to 303 amino acids in length. The N-terminal half of this family is a BTB-like domain.",".",".",".",".","."]
["ENSRNOG00000063011",1536,98.81155305,634,40.93221902,2.414028739,1.271442851,{"v":2.43893E-85,"d":"2.44E-85"},{"v":1.26402e-84,"d":"1.26E-84"},"up","yes","ENSRNOG00000063011","protein_coding","chr1:158035673-158044726:+","gi|148676020|gb|EDL07967.1|",1110,{"v":3E-134,"d":"3.00E-134"},"mCG1029965 [Mus musculus]","gi|46240867|gb|AC107531.8|",3250,0,"Rattus norvegicus 1 BAC CH230-158N3 (Children's Hospital Oakland Research Institute) complete sequence","P11369",214,{"v":3e-55,"d":"3.00E-55"},"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam12488","DUF3704","Protein of unknown function (DUF3704). This domain family is found in eukaryotes, and is approximately 30 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000015072",1375,88.4543525,533,34.4114712,2.570490288,1.362043561,{"v":5.74394e-85,"d":"5.74E-85"},{"v":2.96882e-84,"d":"2.97E-84"},"up","yes","Ptgr1","protein_coding","chr5:73784009-73802666:-","gi|20302022|ref|NP_620218.1|",1606,0,"prostaglandin reductase 1 [Rattus norvegicus]","gi|60097951|ref|NM_138863.2|",998,0,"Rattus norvegicus prostaglandin reductase 1 (Ptgr1), mRNA","P97584",623,0,"Prostaglandin reductase 1","BS_yfmJ",211,{"v":5e-63,"d":"5.00E-63"},"COG2130","pfam00107","ADH_zinc_N","Zinc-binding dehydrogenase.","GO:0006693|prostaglandin metabolic process;GO:0036102|leukotriene B4 metabolic process;GO:0097327|response to antineoplastic agent;GO:2001302|lipoxin A4 metabolic process;","GO:0005737|cytoplasm;","GO:0035798|2-alkenal reductase (NADP+) activity;GO:0036132|13-prostaglandin reductase activity;GO:0036185|13-lipoxin reductase activity;GO:0047522|15-oxoprostaglandin 13-oxidase activity;GO:0097257|leukotriene B4 12-hydroxy dehydrogenase activity;","K13948","PTGR1, LTB4DH; prostaglandin reductase 1 [EC:1.3.1.74 1.3.1.48]"]
["ENSRNOG00000027016",1137,73.14370822,388,25.05000155,2.919908331,1.545923077,{"v":6.35739e-85,"d":"6.36E-85"},{"v":3.28291e-84,"d":"3.28E-84"},"up","yes","Cobll1","protein_coding","chr3:49753262-49915194:-","gi|564341215|ref|XP_006234366.1|",5598,0,"PREDICTED: cordon-bleu protein-like 1 isoform X14 [Rattus norvegicus]","gi|672045934|ref|XM_006234304.2|",4170,0,"PREDICTED: Rattus norvegicus cordon-bleu WH2 repeat protein-like 1 (Cobll1), transcript variant X14, mRNA","Q3UMF0",1720,0,"Cordon-bleu protein-like 1",".",".",".",".","pfam09469","Cobl","Cordon-bleu ubiquitin-like domain. The Cordon-bleu protein domain is highly conserved among vertebrates. The sequence contains three repeated lysine, arginine, and proline-rich regions, the KKRAP motif. The exact function of the protein is unknown but it is thought to be involved in mid-brain neural tube closure. It is expressed specifically in the node. This domain has a ubiquitin-like fold.",".",".","GO:0003785|actin monomer binding;","K24046","COBLL1; cordon-bleu protein-like 1"]
["ENSRNOG00000019441",944,60.72793365,278,17.94819698,3.383511653,1.758521357,{"v":9.33017e-85,"d":"9.33E-85"},{"v":4.80501e-84,"d":"4.81E-84"},"up","yes","Hsd3b2","protein_coding","chr2:186095897-186101852:-","gi|388201|gb|AAA40606.1|",1862,0,"3 hydroxysteroid dehydrogenase [Rattus norvegicus]","gi|61889128|ref|NM_017265.4|",1512,0,"Rattus norvegicus hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6 (Hsd3b6), mRNA","Q62878",725,0,"3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4","YGL001c",104,{"v":8e-24,"d":"8.00E-24"},"COG0451","pfam01073","3Beta_HSD","3-beta hydroxysteroid dehydrogenase/isomerase family. The enzyme 3 beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase (3 beta-HSD) catalyses the oxidation and isomerization of 5-ene-3 beta-hydroxypregnene and 5-ene-hydroxyandrostene steroid precursors into the corresponding 4-ene-ketosteroids necessary for the formation of all classes of steroid hormones.","GO:0006694|steroid biosynthetic process;GO:0006700|C21-steroid hormone biosynthetic process;GO:0006702|androgen biosynthetic process;GO:0008207|C21-steroid hormone metabolic process;GO:0010288|response to lead ion;GO:0021766|hippocampus development;GO:0033327|Leydig cell differentiation;GO:0034698|response to gonadotropin;GO:0034757|negative regulation of iron ion transport;GO:0046686|response to cadmium ion;GO:0051412|response to corticosterone;","GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0031966|mitochondrial membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0045171|intercellular bridge;","GO:0003854|3-beta-hydroxy-delta5-steroid dehydrogenase activity;GO:0004769|steroid delta-isomerase activity;GO:0016616|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0016853|isomerase activity;GO:0030283|testosterone dehydrogenase [NAD(P)] activity;GO:0102294|cholesterol dehydrogenase activity;","K00070","HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]"]
["ENSRNOG00000018969",1598,102.8000402,677,43.70837899,2.351952706,1.23385905,{"v":1.0076E-84,"d":"1.01E-84"},{"v":5.18443e-84,"d":"5.18E-84"},"up","yes","Gpatch4","protein_coding","chr2:173509897-173518684:+","gi|68163385|ref|NP_001020150.1|",1611,0,"G patch domain-containing protein 4 [Rattus norvegicus]","gi|672042890|ref|XM_008761132.1|",1877,0,"PREDICTED: Rattus norvegicus G patch domain containing 4 (Gpatch4), transcript variant X4, mRNA","Q566R3",625,0,"G patch domain-containing protein 4",".",".",".",".","pfam01585","G-patch","G-patch domain. This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.","GO:0002244|hematopoietic progenitor cell differentiation;",".","GO:0003676|nucleic acid binding;",".","."]
["ENSRNOG00000007830",1657,106.5955361,716,46.22629151,2.305950414,1.205361491,{"v":1.12945e-84,"d":"1.13E-84"},{"v":5.80617e-84,"d":"5.81E-84"},"up","yes","Apold1","protein_coding","chr4:167818271-167825706:+","gi|50979282|ref|NP_001003403.1|",890,{"v":4e-108,"d":"4.00E-108"},"apolipoprotein L domain-containing protein 1 [Rattus norvegicus]","gi|50979281|ref|NM_001003403.1|",2883,0,"Rattus norvegicus apolipoprotein L domain containing 1 (Apold1), mRNA","Q6B959",345,{"v":7e-109,"d":"7.00E-109"},"Apolipoprotein L domain-containing protein 1",".",".",".",".","pfam10070","DUF2309","Uncharacterized protein conserved in bacteria (DUF2309). Members of this family of hypothetical bacterial proteins have no known function.","GO:0001525|angiogenesis;GO:0001666|response to hypoxia;GO:0006869|lipid transport;GO:0030154|cell differentiation;GO:0042118|endothelial cell activation;GO:0042157|lipoprotein metabolic process;GO:0045601|regulation of endothelial cell differentiation;","GO:0005576|extracellular region;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0008289|lipid binding;",".","."]
["ENSRNOG00000016321",1936,124.5437283,905,58.42848299,2.131558479,1.091908636,{"v":1.9079E-84,"d":"1.91E-84"},{"v":9.78151e-84,"d":"9.78E-84"},"up","yes","Entpd4","protein_coding","chr15:44630873-44658706:+","gi|564386924|ref|XP_006252339.1|",3154,0,"PREDICTED: ectonucleoside triphosphate diphosphohydrolase 4 isoform X2 [Rattus norvegicus]","gi|672078592|ref|XM_006252277.2|",3028,0,"PREDICTED: Rattus norvegicus ectonucleoside triphosphate diphosphohydrolase 4 (Entpd4), transcript variant X3, mRNA","Q9DBT4",1196,0,"Ectonucleoside triphosphate diphosphohydrolase 4","YER005w",234,{"v":6E-65,"d":"6.00E-65"},"COG5371","pfam01150","GDA1_CD39","GDA1/CD39 (nucleoside phosphatase) family.","GO:0006256|UDP catabolic process;GO:0009134|nucleoside diphosphate catabolic process;GO:0034656|nucleobase-containing small molecule catabolic process;GO:0046036|CTP metabolic process;GO:0046712|GDP catabolic process;","GO:0000139|Golgi membrane;GO:0000421|autophagosome membrane;GO:0005794|Golgi apparatus;GO:0016020|membrane;GO:0030173|integral component of Golgi membrane;GO:0097637|integral component of autophagosome membrane;","GO:0004382|guanosine-diphosphatase activity;GO:0005524|ATP binding;GO:0017110|nucleoside-diphosphatase activity;GO:0017111|nucleoside-triphosphatase activity;GO:0036384|cytidine diphosphatase activity;GO:0043273|CTPase activity;GO:0045134|uridine-diphosphatase activity;","K12305","ENTPD4, LALP70; ectonucleoside triphosphate diphosphohydrolase 4 [EC:3.6.1.6]"]
["ENSRNOG00000010284",1363,87.68238725,528,34.0886619,2.572186245,1.362995108,{"v":2.49059e-84,"d":"2.49E-84"},{"v":1.27574E-83,"d":"1.28E-83"},"up","yes","St3gal5","protein_coding","chr4:104134613-104192558:+","gi|564347292|ref|XP_006236738.1|",2112,0,"PREDICTED: lactosylceramide alpha-2,3-sialyltransferase isoform X2 [Rattus norvegicus]","gi|78126150|ref|NM_031337.2|",2698,0,"Rattus norvegicus ST3 beta-galactoside alpha-2,3-sialyltransferase 5 (St3gal5), mRNA","Q68G12",814,0,"Lactosylceramide alpha-2,3-sialyltransferase",".",".",".",".","pfam00777","Glyco_transf_29","Glycosyltransferase family 29 (sialyltransferase). Members of this family belong to glycosyltransferase family 29.","GO:0006486|protein glycosylation;GO:0097503|sialylation;","GO:0000139|Golgi membrane;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;","GO:0008373|sialyltransferase activity;GO:0047291|lactosylceramide alpha-2,3-sialyltransferase activity;","K03370","SIAT9; lactosylceramide alpha-2,3-sialyltransferase (sialyltransferase 9) [EC:2.4.99.9]"]
["ENSRNOG00000058436",617,39.69188036,114,7.360052001,5.392880425,2.431056046,{"v":7.04243e-84,"d":"7.04E-84"},{"v":3.59442e-83,"d":"3.59E-83"},"up","yes","ENSRNOG00000058436","protein_coding","chr1:61427039-61448888:+","gi|564296543|ref|XP_006223014.1|",4101,0,"PREDICTED: zinc finger protein 52 isoform X1 [Rattus norvegicus]","gi|672034453|ref|XM_008758764.1|",2537,0,"PREDICTED: Rattus norvegicus zinc finger protein 52 (Zfp52), transcript variant X5, mRNA","Q8TAQ5",660,0,"Zinc finger protein 420",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0045944|positive regulation of transcription by RNA polymerase II;",".","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0046872|metal ion binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSRNOG00000002121",1591,102.3497272,678,43.77294085,2.338196273,1.225396038,{"v":1.79694e-83,"d":"1.80E-83"},{"v":9.12254e-83,"d":"9.12E-83"},"up","yes","Lrrc8d","protein_coding","chr14:4029473-4135877:-","gi|347800723|ref|NP_001008339.2|",4523,0,"volume-regulated anion channel subunit LRRC8D [Rattus norvegicus]","gi|672075458|ref|XM_006250556.2|",3569,0,"PREDICTED: Rattus norvegicus leucine rich repeat containing 8 family, member D (Lrrc8d), transcript variant X1, mRNA","Q5U308",1743,0,"Volume-regulated anion channel subunit LRRC8D","alr0124_1",134,{"v":6e-32,"d":"6.00E-32"},"COG4886","pfam12534","DUF3733","Leucine-rich repeat containing protein 8. This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00560. There are two completely conserved residues (W and Y) that may be functionally important. Many of the proteins in this family are annotated as leucine-rich repeat containing protein 8 however there is little accompanying literature to back this up.","GO:0001678|cellular glucose homeostasis;GO:0015698|inorganic anion transport;GO:0015734|taurine transport;GO:0015810|aspartate transmembrane transport;GO:0034214|protein hexamerization;GO:0071470|cellular response to osmotic stress;GO:0098656|anion transmembrane transport;","GO:0005737|cytoplasm;GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;GO:0034702|ion channel complex;","GO:0005225|volume-sensitive anion channel activity;","K22038","LRRC8; volume-regulated anion channel"]
["ENSRNOG00000030245",1087,69.92718631,364,23.50051691,2.975559498,1.573160965,{"v":2.5418e-83,"d":"2.54E-83"},{"v":1.28697E-82,"d":"1.29E-82"},"up","yes","Tango2","protein_coding","chr11:82645974-82692574:+","gi|157820081|ref|NP_001101793.1|",1479,0,"transport and Golgi organization protein 2 homolog [Rattus norvegicus]","gi|157820080|ref|NM_001108323.1|",1571,0,"Rattus norvegicus transport and golgi organization 2 homolog (Tango2), mRNA","P54797",538,0,"Transport and Golgi organization 2 homolog","RSc1780",142,{"v":1e-37,"d":"1.00E-37"},"COG3332","pfam05742","NRDE","NRDE protein. In eukaryotes this family is predicted to play a role in protein secretion and Golgi organisation. In plants this family includes Solanum habrochaites Cwp, which is involved in water permeability in the cuticles of fruit. Mouse T10 has been found to be expressed during early embryogenesis. This protein contains a conserved NRDE motif.","GO:0007030|Golgi organization;GO:0009306|protein secretion;","GO:0005739|mitochondrion;GO:0005794|Golgi apparatus;",".",".","."]
["ENSRNOG00000038001",1894,121.8418499,882,56.94356022,2.13969498,1.097405151,{"v":2.58044E-83,"d":"2.58E-83"},{"v":1.30538E-82,"d":"1.31E-82"},"up","yes","Slc25a1","protein_coding","chr11:83055748-83058781:+","gi|8394297|ref|NP_059003.1|",999,{"v":1e-128,"d":"1.00E-128"},"tricarboxylate transport protein, mitochondrial precursor [Rattus norvegicus]","gi|76881820|ref|NM_017307.3|",1573,0,"Rattus norvegicus solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1 (Slc25a1), mRNA","P32089",389,{"v":4e-130,"d":"4.00E-130"},"Tricarboxylate transport protein, mitochondrial",".",".",".",".","pfam00153","Mito_carr","Mitochondrial carrier protein.","GO:0006843|mitochondrial citrate transmembrane transport;","GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0016021|integral component of membrane;","GO:0015137|citrate transmembrane transporter activity;GO:0071913|citrate secondary active transmembrane transporter activity;","K15100","SLC25A1, CTP; solute carrier family 25 (mitochondrial citrate transporter), member 1"]
["ENSRNOG00000020029",938,60.34195102,280,18.0773207,3.337991952,1.738980476,{"v":5.87532e-83,"d":"5.88E-83"},{"v":2.95645e-82,"d":"2.96E-82"},"up","yes","Mcrip2","protein_coding","chr10:14883813-14894021:-","gi|157823085|ref|NP_001102945.1|",738,{"v":2E-95,"d":"2.00E-95"},"protein FAM195A [Rattus norvegicus]","gi|157823084|ref|NM_001109475.1|",703,0,"Rattus norvegicus family with sequence similarity 195, member A (Fam195a), mRNA","Q9CQB2",269,{"v":5e-89,"d":"5.00E-89"},"MAPK regulated corepressor interacting protein 2",".",".",".",".","pfam14799","FAM195","FAM195 family.",".","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0010494|cytoplasmic stress granule;",".",".","."]
["ENSRNOG00000003386",382,24.57422739,23,1.484922772,16.54916192,4.048686253,{"v":2.93362e-82,"d":"2.93E-82"},{"v":1.46458E-81,"d":"1.46E-81"},"up","yes","Rbfox3","protein_coding","chr10:103720636-104156935:-","gi|672069703|ref|XP_008766567.1|",1309,{"v":1e-170,"d":"1.00E-170"},"PREDICTED: RNA binding protein fox-1 homolog 3 isoform X3 [Rattus norvegicus]","gi|85677498|ref|NM_001024931.2|",2237,0,"Mus musculus RNA binding protein, fox-1 homolog (C. elegans) 3 (Rbfox3), transcript variant 3, mRNA","A6NFN3",488,{"v":6e-164,"d":"6.00E-164"},"RNA binding protein fox-1 homolog 3","TP0356",53.9,1e-07,"COG0724","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0000381|regulation of alternative mRNA splicing, via spliceosome;GO:0006397|mRNA processing;GO:0007399|nervous system development;GO:0008380|RNA splicing;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0043025|neuronal cell body;GO:0043204|perikaryon;","GO:0003677|DNA binding;GO:0003729|mRNA binding;","K14946","RBFOX, FOX; RNA binding protein fox-1"]
["ENSRNOG00000067807",2146,138.0531203,1063,68.62925681,2.01157825,1.00832786,{"v":3.19338e-82,"d":"3.19E-82"},{"v":1.59148E-81,"d":"1.59E-81"},"up","yes","ENSRNOG00000067807","lncRNA","chr14:45191986-45197244:-","gi|149027698|gb|EDL83221.1|",181,{"v":2e-15,"d":"2.00E-15"},"rCG29124 [Rattus norvegicus]","gi|241982901|gb|AC136178.3|",929,0,"Rattus norvegicus CH230-435P16 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P26804",53.1,{"v":2e-13,"d":"2.00E-13"},"Envelope glycoprotein",".",".",".",".","pfam00429","TLV_coat","ENV polyprotein (coat polyprotein).",".",".",".",".","."]
["ENSRNOG00000001926",861,55.38850728,240,15.49484632,3.574640635,1.837798212,{"v":3.34899E-82,"d":"3.35E-82"},{"v":1.66758e-81,"d":"1.67E-81"},"up","yes","Cldn1","protein_coding","chr11:74421569-74436724:+","gi|62296502|sp|P56745.2|CLD1_RAT",883,{"v":2E-107,"d":"2.00E-107"},"RecName: Full=Claudin-1","gi|61889098|ref|NM_031699.2|",3171,0,"Rattus norvegicus claudin 1 (Cldn1), mRNA","P56745",344,{"v":7e-109,"d":"7.00E-109"},"Claudin-1",".",".",".",".","pfam00822","PMP22_Claudin","PMP-22/EMP/MP20/Claudin family.","GO:0007155|cell adhesion;GO:0007568|aging;GO:0008065|establishment of blood-nerve barrier;GO:0009636|response to toxic substance;GO:0016338|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;GO:0030335|positive regulation of cell migration;GO:0032496|response to lipopolysaccharide;GO:0034331|cell junction maintenance;GO:0042538|hyperosmotic salinity response;GO:0045216|cell-cell junction organization;GO:0045471|response to ethanol;GO:0046718|viral entry into host cell;GO:0051259|protein complex oligomerization;GO:0060054|positive regulation of epithelial cell proliferation involved in wound healing;GO:0061436|establishment of skin barrier;GO:0061772|drug transport across blood-nerve barrier;GO:0070673|response to interleukin-18;GO:0070830|bicellular tight junction assembly;GO:0071284|cellular response to lead ion;GO:0071346|cellular response to interferon-gamma;GO:0071356|cellular response to tumor necrosis factor;GO:0071548|response to dexamethasone;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0090303|positive regulation of wound healing;GO:0090557|establishment of endothelial intestinal barrier;GO:0097421|liver regeneration;GO:1903348|positive regulation of bicellular tight junction assembly;GO:1903545|cellular response to butyrate;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005911|cell-cell junction;GO:0005923|bicellular tight junction;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0016328|lateral plasma membrane;GO:0030054|cell junction;GO:0032991|protein-containing complex;GO:0070160|tight junction;","GO:0001618|virus receptor activity;GO:0005198|structural molecule activity;GO:0042802|identical protein binding;","K06087","CLDN; claudin"]
["ENSRNOG00000008351",1031,66.32468177,337,21.7573467,3.048380975,1.608043217,{"v":1.27944e-81,"d":"1.28E-81"},{"v":6.32115e-81,"d":"6.32E-81"},"up","yes","RGD1308117","protein_coding","chr15:45228615-45233254:-","gi|564386926|ref|XP_006252340.1|",1542,0,"PREDICTED: uncharacterized protein C8orf58 homolog isoform X1 [Rattus norvegicus]","gi|672078593|ref|XM_006252278.2|",1941,0,"PREDICTED: Rattus norvegicus similar to 9930012K11Rik protein (RGD1308117), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam15552","DUF4657","Domain of unknown function (DUF4657). This family of proteins is found in eukaryotes. Proteins in this family are typically between 305 and 370 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000062648",1184,76.16723881,429,27.69703779,2.750013896,1.459438909,{"v":2.68816e-81,"d":"2.69E-81"},{"v":1.32353e-80,"d":"1.32E-80"},"up","yes","ENSRNOG00000062648","lncRNA","chr3:14169402-14189337:-","gi|11024658|ref|NP_067594.1|",814,{"v":9e-96,"d":"9.00E-96"},"prostaglandin E synthase [Rattus norvegicus]","gi|402693403|ref|NM_021583.3|",1248,0,"Rattus norvegicus prostaglandin E synthase (Ptges), mRNA","Q9JM51",299,{"v":9e-91,"d":"9.00E-91"},"Prostaglandin E synthase",".",".",".",".","pfam01124","MAPEG","MAPEG family. This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolizm). It includes proteins such as Prostaglandin E synthase. This enzyme catalyses the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.",".",".",".",".","."]
["ENSRNOG00000013851",762,49.0197939,192,12.39587705,3.954524047,1.983504067,{"v":1.31718E-80,"d":"1.32E-80"},{"v":6.42426e-80,"d":"6.42E-80"},"up","yes","Spry4","protein_coding","chr18:30436443-30453004:-","gi|672083159|ref|XP_008770289.1|",1383,{"v":2e-173,"d":"2.00E-173"},"PREDICTED: protein sprouty homolog 4 isoform X1 [Rattus norvegicus]","gi|157817802|ref|NM_001106150.1|",4728,0,"Rattus norvegicus sprouty RTK signaling antagonist 4 (Spry4), mRNA","Q9WTP2",494,{"v":4E-160,"d":"4.00E-160"},"Protein sprouty homolog 4",".",".",".",".","pfam05210","Sprouty","Sprouty protein (Spry). This family consists of eukaryotic Sprouty protein homologues. Sprouty proteins have been revealed as inhibitors of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases. The sprouty gene has found to be expressed in the the brain, cochlea, nasal organs, teeth, salivary gland, lungs, digestive tract, kidneys and limb buds in mice.","GO:0040037|negative regulation of fibroblast growth factor receptor signaling pathway;GO:0043407|negative regulation of MAP kinase activity;GO:0046580|negative regulation of Ras protein signal transduction;GO:0048513|animal organ development;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:1900025|negative regulation of substrate adhesion-dependent cell spreading;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016020|membrane;","GO:0004860|protein kinase inhibitor activity;","K17385","SPRY4; protein sprouty homolog 4"]
["ENSRNOG00000011826",582,37.44031502,105,6.778995264,5.522988816,2.465449206,{"v":1.72719e-80,"d":"1.73E-80"},{"v":8.39531e-80,"d":"8.40E-80"},"up","yes","Lzts1","protein_coding","chr16:20542809-20598203:+","gi|23618893|ref|NP_703200.1|",2802,0,"leucine zipper putative tumor suppressor 1 [Rattus norvegicus]","gi|23618892|ref|NM_153470.1|",4968,0,"Rattus norvegicus leucine zipper, putative tumor suppressor 1 (Lzts1), mRNA","Q8CFC9",1083,0,"Leucine zipper putative tumor suppressor 1",".",".",".",".","pfam06818","Fez1","Fez1. This family represents the eukaryotic Fez1 protein. Fez1 contains a leucine-zipper region with similarity to the DNA-binding domain of the cAMP-responsive activating-transcription factor 5. There is evidence that Fez1 inhibits cancer cell growth through regulation of mitosis, and that its alterations result in abnormal cell growth. Note that some family members contain more than one copy of this region.","GO:0016242|negative regulation of macroautophagy;GO:0044772|mitotic cell cycle phase transition;GO:0048167|regulation of synaptic plasticity;GO:0048814|regulation of dendrite morphogenesis;","GO:0005737|cytoplasm;GO:0014069|postsynaptic density;GO:0016324|apical plasma membrane;GO:0043005|neuron projection;GO:0043197|dendritic spine;GO:0043198|dendritic shaft;GO:0044297|cell body;GO:0045202|synapse;GO:0045211|postsynaptic membrane;","GO:0005515|protein binding;GO:0008017|microtubule binding;",".","."]
["ENSRNOG00000066637",1951,125.5086849,937,60.4944625,2.074713614,1.052912206,{"v":2.65681e-80,"d":"2.66E-80"},{"v":1.2881e-79,"d":"1.29E-79"},"up","yes","Rps10l1","protein_coding","chr6:72030876-72031440:+","gi|346421343|ref|NP_001231035.1|",675,{"v":3e-87,"d":"3.00E-87"},"ribosomal protein S10 [Sus scrofa]","gi|564307185|ref|XM_003754173.2|",565,0,"PREDICTED: Rattus norvegicus ribosomal protein S10-like 1 (Rps10l1), mRNA","P63326",264,{"v":1e-88,"d":"1.00E-88"},"40S ribosomal protein S10","SPBP22H7.08",129,{"v":9e-37,"d":"9.00E-37"},"COG5045","pfam03501","S10_plectin","Plectin/S10 domain. This presumed domain is found at the N-terminus of some isoforms of the cytoskeletal muscle protein plectin as well as the ribosomal S10 protein. This domain may be involved in RNA binding.",".",".",".",".","."]
["ENSRNOG00000007875",1130,72.69339515,402,25.95386758,2.800869463,1.485874747,{"v":9.93906e-80,"d":"9.94E-80"},{"v":4.7984e-79,"d":"4.80E-79"},"up","yes","Actr6","protein_coding","chr7:24150250-24171067:-","gi|564358945|ref|XP_006241305.1|",2012,0,"PREDICTED: actin-related protein 6 isoform X1 [Rattus norvegicus]","gi|564358944|ref|XM_006241243.1|",1703,0,"PREDICTED: Rattus norvegicus ARP6 actin-related protein 6 homolog (yeast) (Actr6), transcript variant X1, mRNA","Q9D864",775,0,"Actin-related protein 6",".",".",".",".","pfam00022","Actin","Actin.","GO:0008150|biological_process;GO:0043486|histone exchange;","GO:0000812|Swr1 complex;GO:0005575|cellular_component;GO:0005634|nucleus;","GO:0003674|molecular_function;GO:0031491|nucleosome binding;","K11662","ACTR6, ARP6; actin-related protein 6"]
["ENSRNOG00000010390",1235,79.44809116,467,30.15038846,2.635060283,1.397835967,{"v":1.63648E-79,"d":"1.64E-79"},{"v":7.88062e-79,"d":"7.88E-79"},"up","yes","Hmbs","protein_coding","chr8:44673554-44680957:-","gi|564363292|ref|XP_006242958.1|",2207,0,"PREDICTED: porphobilinogen deaminase isoform X2 [Rattus norvegicus]","gi|564363291|ref|XM_006242896.1|",1622,0,"PREDICTED: Rattus norvegicus hydroxymethylbilane synthase (Hmbs), transcript variant X2, mRNA","P19356",709,0,"Porphobilinogen deaminase","alr1878",309,{"v":1e-98,"d":"1.00E-98"},"COG0181","pfam01379","Porphobil_deam","Porphobilinogen deaminase, dipyromethane cofactor binding domain.","GO:0001666|response to hypoxia;GO:0001889|liver development;GO:0006778|porphyrin-containing compound metabolic process;GO:0006779|porphyrin-containing compound biosynthetic process;GO:0006782|protoporphyrinogen IX biosynthetic process;GO:0006783|heme biosynthetic process;GO:0009410|response to xenobiotic stimulus;GO:0009725|response to hormone;GO:0009743|response to carbohydrate;GO:0010038|response to metal ion;GO:0010043|response to zinc ion;GO:0010288|response to lead ion;GO:0014070|response to organic cyclic compound;GO:0018160|peptidyl-pyrromethane cofactor linkage;GO:0031100|animal organ regeneration;GO:0031667|response to nutrient levels;GO:0032025|response to cobalt ion;GO:0032355|response to estradiol;GO:0033014|tetrapyrrole biosynthetic process;GO:0033273|response to vitamin;GO:0043200|response to amino acid;GO:0048708|astrocyte differentiation;GO:0051597|response to methylmercury;GO:0071236|cellular response to antibiotic;GO:0071243|cellular response to arsenic-containing substance;GO:0071284|cellular response to lead ion;GO:0071345|cellular response to cytokine stimulus;GO:0071418|cellular response to amine stimulus;GO:0071549|cellular response to dexamethasone stimulus;","GO:0000793|condensed chromosome;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0030424|axon;GO:0048471|perinuclear region of cytoplasm;","GO:0004418|hydroxymethylbilane synthase activity;GO:0004852|uroporphyrinogen-III synthase activity;GO:0005515|protein binding;GO:0031406|carboxylic acid binding;GO:0043176|amine binding;","K01749","hemC, HMBS; hydroxymethylbilane synthase [EC:2.5.1.61]"]
["ENSRNOG00000016734",869,55.90315078,254,16.39871235,3.408996364,1.769347061,{"v":7.95688e-79,"d":"7.96E-79"},{"v":3.81243E-78,"d":"3.81E-78"},"up","yes","Emilin3","protein_coding","chr3:149558970-149564785:-","gi|158138570|ref|NP_001103371.1|",3353,0,"EMILIN-3 precursor [Rattus norvegicus]","gi|564344185|ref|XM_006235495.1|",2626,0,"PREDICTED: Rattus norvegicus elastin microfibril interfacer 3 (Emilin3), transcript variant X1, mRNA","P59900",1205,0,"EMILIN-3",".",".",".",".","pfam07546","EMI","EMI domain. The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.",".","GO:0005737|cytoplasm;","GO:0042802|identical protein binding;","K24246","EMILIN; emilin"]
["ENSRNOG00000007748",972,62.52918592,312,20.14330021,3.104217544,1.634229665,{"v":8.00222e-79,"d":"8.00E-79"},{"v":3.83095e-78,"d":"3.83E-78"},"up","yes","Tex15","protein_coding","chr16:58598989-58658467:-","gi|564389384|ref|XP_006253280.1|",16266,0,"PREDICTED: testis-expressed sequence 15 protein isoform X1 [Rattus norvegicus]","gi|672080305|ref|XM_008771297.1|",9477,0,"PREDICTED: Rattus norvegicus testis expressed 15 (Tex15), transcript variant X3, mRNA","F8VPN2",4348,0,"Testis-expressed protein 15",".",".",".",".","pfam15326","TEX15","Testis expressed sequence 15. TEX15 is a family of eukaryotic proteins that is required for chromosomal synapsis and meiotic recombination. TEX15 regulates the loading of DNA repair proteins onto sites of double-stranded-breaks and, thus, its absence causes a failure in meiotic recombination. Two polymorphisms in the TEX15 gene could be considered the genetic risk factors for spermatogenic failure in the Chinese Han population.","GO:0006306|DNA methylation;GO:0007129|synapsis;GO:0007130|synaptonemal complex assembly;GO:0007140|male meiotic nuclear division;GO:0007283|spermatogenesis;GO:0009566|fertilization;GO:0010529|negative regulation of transposition;GO:0010569|regulation of double-strand break repair via homologous recombination;GO:0030539|male genitalia development;GO:0032880|regulation of protein localization;GO:0034502|protein localization to chromosome;GO:0048873|homeostasis of number of cells within a tissue;","GO:0005634|nucleus;GO:0005737|cytoplasm;",".","K25680","TEX15; testis-expressed protein 15"]
["ENSRNOG00000026646",1935,124.4793979,935,60.36533878,2.062100543,1.044114677,{"v":1.3433E-78,"d":"1.34E-78"},{"v":6.40935e-78,"d":"6.41E-78"},"up","yes","Ndufs5","protein_coding","chr5:135974034-135979603:-","gi|149023886|gb|EDL80383.1|",775,{"v":9E-102,"d":"9.00E-102"},"rCG31129, isoform CRA_a [Rattus norvegicus]","gi|672053778|ref|XM_006238828.2|",430,0,"PREDICTED: Rattus norvegicus NADH dehydrogenase (ubiquinone) Fe-S protein 5 (Ndufs5), transcript variant X2, mRNA","Q99LY9",205,{"v":1e-65,"d":"1.00E-65"},"NADH dehydrogenase [ubiquinone] iron-sulfur protein 5",".",".",".",".","pfam10200","Ndufs5","NADH:ubiquinone oxidoreductase, NDUFS5-15kDa. This is a family of short, approximately 105 amino acid residue, proteins which form part of NADH:ubiquinone oxidoreductase complex I. Complex I is the first multisubunit inner membrane protein complex of the mitochondrial electron transport chain and it transfers two electrons from NADH to ubiquinone. The protein carries four highly conserved cysteine residues but these do not appear to be in a configuration which would favour metal binding so the exact function of the protein is uncertain.","GO:0008150|biological_process;GO:0032981|mitochondrial respiratory chain complex I assembly;","GO:0005575|cellular_component;GO:0005739|mitochondrion;GO:0005747|mitochondrial respiratory chain complex I;","GO:0003674|molecular_function;","K03938","NDUFS5; NADH dehydrogenase (ubiquinone) Fe-S protein 5"]
["ENSRNOG00000003616",1411,90.77024828,587,37.89781162,2.395131655,1.26010496,{"v":1.7509e-77,"d":"1.75E-77"},{"v":8.28494e-77,"d":"8.28E-77"},"up","yes","Grem2","protein_coding","chr13:86778500-86871615:-","gi|157787016|ref|NP_001099444.1|",802,{"v":9e-96,"d":"9.00E-96"},"gremlin-2 precursor [Rattus norvegicus]","gi|157787015|ref|NM_001105974.1|",3716,0,"Rattus norvegicus gremlin 2 (Grem2), mRNA","O88273",312,{"v":9e-97,"d":"9.00E-97"},"Gremlin-2",".",".",".",".","pfam03045","DAN","DAN domain. This domain contains 9 conserved cysteines and is extracellular. Therefore the cysteines may form disulphide bridges. This family of proteins has been termed the DAN family after the first member to be reported. This family includes DAN, Cerberus and Gremlin. The gremlin protein is an antagonist of bone morphogenetic protein signaling. It is postulated that all members of this family antagonise different TGF beta pfam00019 ligands. Recent work shows that the DAN protein is not an efficient antagonist of BMP-2/4 class signals, we found that DAN was able to interact with GDF-5 in a frog embryo assay, suggesting that DAN may regulate signaling by the GDF-5/6/7 class of BMPs in vivo.","GO:0009887|animal organ morphogenesis;GO:0010172|embryonic body morphogenesis;GO:0019221|cytokine-mediated signaling pathway;GO:0030514|negative regulation of BMP signaling pathway;GO:0038098|sequestering of BMP from receptor via BMP binding;GO:0048263|determination of dorsal identity;GO:0060300|regulation of cytokine activity;","GO:0005615|extracellular space;","GO:0005125|cytokine activity;GO:0008201|heparin binding;GO:0036122|BMP binding;GO:0042802|identical protein binding;GO:0048018|receptor ligand activity;","K23318","GREM; gremlin"]
["ENSRNOG00000005299",479,30.81427989,67,4.325644597,7.123627288,2.832612036,{"v":4.45678E-77,"d":"4.46E-77"},{"v":2.10364e-76,"d":"2.10E-76"},"up","yes","Kif5a","protein_coding","chr7:63049424-63092858:-","gi|47058980|ref|NP_997688.1|",4979,0,"kinesin heavy chain isoform 5A [Rattus norvegicus]","gi|298898969|emb|FQ212220.1|",5952,0,"Rattus norvegicus TL0AAA65YC10 mRNA sequence","Q6QLM7",1922,0,"Kinesin heavy chain isoform 5A","SPAC1834.07",323,{"v":1e-94,"d":"1.00E-94"},"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0007017|microtubule-based process;GO:0007018|microtubule-based movement;GO:0007411|axon guidance;GO:0016192|vesicle-mediated transport;GO:0021766|hippocampus development;GO:0021794|thalamus development;GO:0021987|cerebral cortex development;GO:0030705|cytoskeleton-dependent intracellular transport;GO:0048489|synaptic vesicle transport;GO:0048666|neuron development;GO:0071361|cellular response to ethanol;GO:0098971|anterograde dendritic transport of neurotransmitter receptor complex;GO:0099641|anterograde axonal protein transport;GO:1904647|response to rotenone;GO:1990049|retrograde neuronal dense core vesicle transport;GO:1990090|cellular response to nerve growth factor stimulus;","GO:0000932|P-body;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005871|kinesin complex;GO:0005874|microtubule;GO:0030424|axon;GO:0030425|dendrite;GO:0032839|dendrite cytoplasm;GO:0035253|ciliary rootlet;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0048471|perinuclear region of cytoplasm;GO:0090724|central region of growth cone;GO:0097440|apical dendrite;GO:1904115|axon cytoplasm;","GO:0003777|microtubule motor activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0008017|microtubule binding;GO:0008574|ATP-dependent microtubule motor activity, plus-end-directed;GO:0016887|ATPase activity;GO:0019894|kinesin binding;GO:0044877|protein-containing complex binding;GO:0097110|scaffold protein binding;","K10396","KIF5; kinesin family member 5"]
["ENSRNOG00000027089",1298,83.50090876,517,33.37848144,2.501638935,1.322873578,{"v":7.02301e-77,"d":"7.02E-77"},{"v":3.30128e-76,"d":"3.30E-76"},"up","yes","Ell2","protein_coding","chr2:5189971-5258781:+","gi|293345072|ref|XP_001054852.2|",3043,0,"PREDICTED: RNA polymerase II elongation factor ELL2 isoform X1 [Rattus norvegicus]","gi|672040999|ref|XM_008760603.1|",3543,0,"PREDICTED: Rattus norvegicus elongation factor RNA polymerase II 2 (Ell2), transcript variant X1, mRNA","Q3UKU1",1110,0,"RNA polymerase II elongation factor ELL2",".",".",".",".","pfam10390","ELL","RNA polymerase II elongation factor ELL. ELL is a family of RNA polymerase II elongation factors. It is bound stably to elongation-associated factors 1 and 2, EAFs, and together these act as a strong regulator of transcription activity. by direct interaction with Pol II. ELL binds to pol II on its own but the affinity is greatly increased by the cooperation of EAF. Some members carry an Occludin domain pfam07303 just downstream. There is no S. cerevisiae member.","GO:0006368|transcription elongation from RNA polymerase II promoter;GO:0008150|biological_process;GO:0042795|snRNA transcription by RNA polymerase II;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0008023|transcription elongation factor complex;","GO:0003674|molecular_function;","K15183","ELL; RNA polymerase II elongation factor ELL"]
["ENSRNOG00000007202",563,36.2180367,105,6.778995264,5.342685057,2.417564975,{"v":3.19964E-76,"d":"3.20E-76"},{"v":1.50034e-75,"d":"1.50E-75"},"up","yes","Sema3d","protein_coding","chr4:22316779-22505930:-","gi|157277992|ref|NP_001098103.1|",4147,0,"semaphorin-3D [Rattus norvegicus]","gi|157277991|ref|NM_001104633.1|",4912,0,"Rattus norvegicus semaphorin 3D (Sema3d), mRNA","Q8BH34",1566,0,"Semaphorin-3D",".",".",".",".","pfam01403","Sema","Sema domain. The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and human plexin A-3.","GO:0001755|neural crest cell migration;GO:0007411|axon guidance;GO:0030335|positive regulation of cell migration;GO:0048843|negative regulation of axon extension involved in axon guidance;GO:0050919|negative chemotaxis;GO:0071526|semaphorin-plexin signaling pathway;","GO:0005615|extracellular space;GO:0005887|integral component of plasma membrane;","GO:0030215|semaphorin receptor binding;GO:0045499|chemorepellent activity;","K06840","SEMA3; semaphorin 3"]
["ENSRNOG00000063577",1920,123.5144413,938,60.55902436,2.039571189,1.028265864,{"v":4.0711E-76,"d":"4.07E-76"},{"v":1.90429E-75,"d":"1.90E-75"},"up","yes","ENSRNOG00000063577","protein_coding","chr1:61368076-61395282:+","gi|672034684|ref|XP_008757045.1|",3362,0,"PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 678-like isoform X2 [Rattus norvegicus]","gi|672034683|ref|XM_008758823.1|",2088,0,"PREDICTED: Rattus norvegicus zinc finger protein 420-like (LOC102550851), transcript variant X2, mRNA","Q8TAQ5",548,0,"Zinc finger protein 420",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000009267",1805,116.1164409,863,55.71688488,2.084044023,1.059385753,{"v":3.65689e-75,"d":"3.66E-75"},{"v":1.69252E-74,"d":"1.69E-74"},"up","yes","B3gnt2","protein_coding","chr14:96806664-96835273:-","gi|157822021|ref|NP_001100710.1|",2071,0,"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 [Rattus norvegicus]","gi|157822020|ref|NM_001107240.1|",2536,0,"Rattus norvegicus UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (B3gnt2), mRNA","Q9Z222",778,0,"N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2",".",".",".",".","pfam01762","Galactosyl_T","Galactosyltransferase. This family includes the galactosyltransferases UDP-galactose:2-acetamido-2-deoxy-D-glucose3beta-galactosyltransferase and UDP-Gal:beta-GlcNAc beta 1,3-galactosyltranferase. Specific galactosyltransferases transfer galactose to GlcNAc terminal chains in the synthesis of the lacto-series oligosaccharides types 1 and 2.","GO:0006486|protein glycosylation;GO:0007411|axon guidance;GO:0007608|sensory perception of smell;GO:0008150|biological_process;GO:0030311|poly-N-acetyllactosamine biosynthetic process;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0000139|Golgi membrane;GO:0005575|cellular_component;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0008194|UDP-glycosyltransferase activity;GO:0008532|N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity;GO:0016757|transferase activity, transferring glycosyl groups;","K00741","B3GNT2; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase [EC:2.4.1.149]"]
["ENSRNOG00000045553",613,39.43455861,131,8.457603615,4.662616079,2.221139643,{"v":5.10948E-75,"d":"5.11E-75"},{"v":2.3629e-74,"d":"2.36E-74"},"up","yes","Proser2","protein_coding","chr17:72151872-72185825:+","gi|109506072|ref|XP_001065403.1|",2116,0,"PREDICTED: proline and serine-rich protein 2 [Rattus norvegicus]","gi|672082544|ref|XM_008771898.1|",2329,0,"PREDICTED: Rattus norvegicus proline and serine rich 2 (Proser2), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam15385","SARG","Specifically androgen-regulated gene protein. This family of proteins is found in eukaryotes, the function of this protein is still unknown but it is thought to be an androgen receptor. Protein expression is up-regulated in the presence of androgens, but not in the presence of glucocorticoids. SARG tends to be highly expressed in prostate tissue. Proteins in this family are typically between 340 and 587 amino acids in length. There is a conserved EETI sequence motif.",".",".",".",".","."]
["ENSRNOG00000024426",930,59.82730751,303,19.56224348,3.058305025,1.612732303,{"v":4.13167e-74,"d":"4.13E-74"},{"v":1.89536e-73,"d":"1.90E-73"},"up","yes","AABR07032520.1","protein_coding","chr18:67450595-67467044:+","gi|564320831|ref|XP_006222676.1|",1531,0,"PREDICTED: protein maestro isoform X1 [Rattus norvegicus]","gi|672030818|ref|XM_006222615.2|",1403,0,"PREDICTED: Rattus norvegicus maestro (Mro), transcript variant X2, mRNA","Q7TNB4",437,{"v":6e-151,"d":"6.00E-151"},"Protein maestro",".",".",".",".","pfam03999","MAP65_ASE1","Microtubule associated protein (MAP65/ASE1 family).",".",".",".",".","."]
["ENSRNOG00000012701",1315,84.59452621,540,34.86340421,2.426456283,1.278850868,{"v":5.56672E-74,"d":"5.57E-74"},{"v":2.55163E-73,"d":"2.55E-73"},"up","yes","Map7","protein_coding","chr1:14910551-15037574:+","gi|310772205|ref|NP_001099740.2|",1617,0,"ensconsin isoform 1 [Rattus norvegicus]","gi|310772204|ref|NM_001106270.2|",1113,0,"Rattus norvegicus microtubule-associated protein 7 (Map7), transcript variant 1, mRNA","O88735",444,{"v":1E-136,"d":"1.00E-136"},"Ensconsin",".",".",".",".","pfam15402","Spc7_N","N-terminus of kinetochore NMS complex subunit Spc7.","GO:0000226|microtubule cytoskeleton organization;GO:0000902|cell morphogenesis;GO:0001578|microtubule bundle formation;GO:0006687|glycosphingolipid metabolic process;GO:0006970|response to osmotic stress;GO:0006997|nucleus organization;GO:0007281|germ cell development;GO:0007283|spermatogenesis;GO:0008283|cell proliferation;GO:0009566|fertilization;GO:0032526|response to retinoic acid;GO:0033327|Leydig cell differentiation;GO:0035265|organ growth;GO:0048872|homeostasis of number of cells;GO:0060009|Sertoli cell development;GO:0072659|protein localization to plasma membrane;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0015630|microtubule cytoskeleton;GO:0030424|axon;","GO:0005102|signaling receptor binding;","K10433","MAP7; microtubule-associated protein 7"]
["ENSRNOG00000008374",1423,91.54221354,611,39.44729625,2.320620733,1.214510757,{"v":7.76462e-74,"d":"7.76E-74"},{"v":3.55623e-73,"d":"3.56E-73"},"up","yes","Nipsnap1","protein_coding","chr14:79734209-79758098:+","gi|149047581|gb|EDM00251.1|",1411,0,"4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (C. elegans), isoform CRA_e [Rattus norvegicus]","gi|209969743|ref|NM_001100730.1|",1771,0,"Rattus norvegicus nipsnap homolog 1 (C. elegans) (Nipsnap1), mRNA","O55125",530,{"v":3e-177,"d":"3.00E-177"},"Protein NipSnap homolog 1",".",".",".",".","pfam07978","NIPSNAP","NIPSNAP. Members of this family include many hypothetical proteins. It also includes members of the NIPSNAP family which have putative roles in vesicular transport. This domain is often found in duplicate.","GO:0019233|sensory perception of pain;","GO:0005739|mitochondrion;GO:0016020|membrane;GO:0097060|synaptic membrane;","GO:0042165|neurotransmitter binding;",".","."]
["ENSRNOG00000010633",1281,82.40729131,521,33.63672888,2.449919896,1.292734579,{"v":2.63768e-73,"d":"2.64E-73"},{"v":1.19941e-72,"d":"1.20E-72"},"up","yes","Acsl1","protein_coding","chr16:45755254-45821541:-","gi|25742739|ref|NP_036952.1|",3604,0,"long-chain-fatty-acid--CoA ligase 1 [Rattus norvegicus]","gi|564389118|ref|XM_006253123.1|",3758,0,"PREDICTED: Rattus norvegicus acyl-CoA synthetase long-chain family member 1 (Acsl1), transcript variant X1, mRNA","P18163",1392,0,"Long-chain-fatty-acid--CoA ligase 1","YER015w",313,{"v":1e-90,"d":"1.00E-90"},"COG1022","pfam00501","AMP-binding","AMP-binding enzyme.","GO:0000038|very long-chain fatty acid metabolic process;GO:0001676|long-chain fatty acid metabolic process;GO:0006629|lipid metabolic process;GO:0006631|fatty acid metabolic process;GO:0007584|response to nutrient;GO:0008610|lipid biosynthetic process;GO:0009410|response to xenobiotic stimulus;GO:0010033|response to organic substance;GO:0010747|positive regulation of plasma membrane long-chain fatty acid transport;GO:0014070|response to organic cyclic compound;GO:0015908|fatty acid transport;GO:0019432|triglyceride biosynthetic process;GO:0033211|adiponectin-activated signaling pathway;GO:0034201|response to oleic acid;GO:0035338|long-chain fatty-acyl-CoA biosynthetic process;GO:0042178|xenobiotic catabolic process;GO:0044539|long-chain fatty acid import;GO:0071902|positive regulation of protein serine/threonine kinase activity;GO:0120162|positive regulation of cold-induced thermogenesis;","GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0005778|peroxisomal membrane;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0003987|acetate-CoA ligase activity;GO:0004467|long-chain fatty acid-CoA ligase activity;GO:0005524|ATP binding;GO:0047676|arachidonate-CoA ligase activity;GO:0050197|phytanate-CoA ligase activity;GO:0070251|pristanate-CoA ligase activity;GO:0090434|oleoyl-CoA ligase activity;","K01897","ACSL, fadD; long-chain acyl-CoA synthetase [EC:6.2.1.3]"]
["ENSRNOG00000015212",1005,64.65209038,350,22.59665088,2.861135959,1.516588055,{"v":3.02983e-73,"d":"3.03E-73"},{"v":1.37445E-72,"d":"1.37E-72"},"up","yes","Hspa14","protein_coding","chr17:74728899-74749727:+","gi|51948484|ref|NP_001004257.1|",2684,0,"heat shock 70 kDa protein 14 [Rattus norvegicus]","gi|51948483|ref|NM_001004257.1|",1737,0,"Rattus norvegicus heat shock protein family A, member 14 (Hspa14), mRNA","Q6AYB4",1038,0,"Heat shock 70 kDa protein 14","YBL075c",330,{"v":7e-103,"d":"7.00E-103"},"COG0443","pfam00012","HSP70","Hsp70 protein. Hsp70 chaperones help to fold many proteins. Hsp70 assisted folding involves repeated cycles of substrate binding and release. Hsp70 activity is ATP dependent. Hsp70 proteins are made up of two regions: the amino terminus is the ATPase domain and the carboxyl terminus is the substrate binding region.","GO:0016192|vesicle-mediated transport;GO:0034620|cellular response to unfolded protein;GO:0042026|protein refolding;GO:0051085|chaperone cofactor-dependent protein refolding;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005840|ribosome;GO:0005886|plasma membrane;","GO:0005524|ATP binding;GO:0016887|ATPase activity;GO:0031072|heat shock protein binding;GO:0044183|protein binding involved in protein folding;GO:0051082|unfolded protein binding;GO:0051787|misfolded protein binding;",".","."]
["ENSRNOG00000069161",420,27.01878404,50,3.228092983,8.369890267,3.065208709,{"v":4.15469e-73,"d":"4.15E-73"},{"v":1.88174e-72,"d":"1.88E-72"},"up","yes","ENSRNOG00000069161","lncRNA","chr17:66027501-66033568:-","gi|149032233|gb|EDL87139.1|",593,{"v":5e-66,"d":"5.00E-66"},"rCG63135 [Rattus norvegicus]","gi|240851455|gb|AC139609.2|",5421,0,"Rattus norvegicus CH230-381A11 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P11369",227,{"v":2e-58,"d":"2.00E-58"},"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam12488","DUF3704","Protein of unknown function (DUF3704). This domain family is found in eukaryotes, and is approximately 30 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000019902",1556,100.0981618,704,45.4515492,2.202304731,1.139014107,{"v":6.42363e-73,"d":"6.42E-73"},{"v":2.89561e-72,"d":"2.90E-72"},"up","yes","Folr1","protein_coding","chr1:156219460-156230667:-","gi|924859482|ref|NP_598211.2|",1303,{"v":3e-177,"d":"3.00E-177"},"folate receptor alpha precursor [Rattus norvegicus]","gi|924859481|ref|NM_133527.2|",1279,0,"Rattus norvegicus folate receptor 1 (adult) (Folr1), mRNA","P35846",469,{"v":4e-164,"d":"4.00E-164"},"Folate receptor alpha",".",".",".",".","pfam03024","Folate_rec","Folate receptor family. This family includes the folate receptor which binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. These proteins are attached to the membrane by a GPI-anchor. The proteins contain 16 conserved cysteines that form eight disulphide bridges.","GO:0001947|heart looping;GO:0003147|neural crest cell migration involved in heart formation;GO:0003253|cardiac neural crest cell migration involved in outflow tract morphogenesis;GO:0007155|cell adhesion;GO:0007342|fusion of sperm to egg plasma membrane involved in single fertilization;GO:0015884|folic acid transport;GO:0017015|regulation of transforming growth factor beta receptor signaling pathway;GO:0031103|axon regeneration;GO:0035036|sperm-egg recognition;GO:0046655|folic acid metabolic process;GO:0048678|response to axon injury;GO:0060828|regulation of canonical Wnt signaling pathway;GO:0061626|pharyngeal arch artery morphogenesis;GO:0061713|anterior neural tube closure;GO:0071231|cellular response to folic acid;GO:1904447|folate import across plasma membrane;","GO:0005634|nucleus;GO:0005903|brush border;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0031362|anchored component of external side of plasma membrane;GO:0031526|brush border membrane;GO:0046658|anchored component of plasma membrane;","GO:0005542|folic acid binding;GO:0038023|signaling receptor activity;GO:0051870|methotrexate binding;GO:0061714|folic acid receptor activity;","K13649","FOLR; folate receptor"]
["ENSRNOG00000020194",1322,85.04483928,550,35.50902281,2.395020548,1.260038034,{"v":1.04371E-72,"d":"1.04E-72"},{"v":4.69734e-72,"d":"4.70E-72"},"up","yes","Hes6","protein_coding","chr9:92001841-92003559:-","gi|61557199|ref|NP_001013197.1|",1022,{"v":2e-134,"d":"2.00E-134"},"transcription cofactor HES-6 [Rattus norvegicus]","gi|61557198|ref|NM_001013179.1|",1385,0,"Rattus norvegicus hes family bHLH transcription factor 6 (Hes6), mRNA","Q9JHE6",312,{"v":2e-102,"d":"2.00E-102"},"Transcription cofactor HES-6",".",".",".",".","pfam07527","Hairy_orange","Hairy Orange. The Orange domain is found in the Drosophila proteins Hesr-1, Hairy, and Enhancer of Split. The Orange domain is proposed to mediate specific protein-protein interaction between Hairy and Scute.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007399|nervous system development;GO:0009952|anterior/posterior pattern specification;GO:0030154|cell differentiation;GO:0043433|negative regulation of DNA-binding transcription factor activity;GO:0050767|regulation of neurogenesis;","GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0046983|protein dimerization activity;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09087","HES2_6_7; hairy and enhancer of split 2/6/7"]
["ENSRNOG00000059705",1342,86.33144804,563,36.34832699,2.375114763,1.247997225,{"v":1.04615E-72,"d":"1.05E-72"},{"v":4.70463e-72,"d":"4.70E-72"},"up","yes","Elmo1","protein_coding","chr17:44286485-44822788:-","gi|148700731|gb|EDL32678.1|",4003,0,"engulfment and cell motility 1, ced-12 homolog (C. elegans), isoform CRA_b [Mus musculus]","gi|755544087|ref|XM_006516546.2|",2767,0,"PREDICTED: Mus musculus engulfment and cell motility 1 (Elmo1), transcript variant X3, mRNA","Q8BPU7",1466,0,"Engulfment and cell motility protein 1",".",".",".",".","pfam11841","DUF3361","Domain of unknown function (DUF3361). This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is typically between 154 to 168 amino acids in length.","GO:0006909|phagocytosis;GO:0006911|phagocytosis, engulfment;GO:0006915|apoptotic process;GO:0007015|actin filament organization;GO:0016477|cell migration;GO:0016601|Rac protein signal transduction;GO:0030029|actin filament-based process;GO:0030036|actin cytoskeleton organization;GO:0048870|cell motility;GO:0050790|regulation of catalytic activity;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0032045|guanyl-nucleotide exchange factor complex;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0017124|SH3 domain binding;","K12366","ELMO1, CED12; engulfment and cell motility protein 1"]
["ENSRNOG00000025273",577,37.11866283,119,7.682861299,4.831359228,2.272429126,{"v":1.14163e-72,"d":"1.14E-72"},{"v":5.12998e-72,"d":"5.13E-72"},"up","yes","AABR07068728.1","protein_coding","chr9:108329669-108747774:+","gi|569000585|ref|XP_006524479.1|",3049,0,"PREDICTED: lethal(3)malignant brain tumor-like protein 4 isoform X1 [Mus musculus]","gi|569000586|ref|XM_006524417.1|",2080,0,"PREDICTED: Mus musculus l(3)mbt-like 4 (Drosophila) (L3mbtl4), transcript variant X2, mRNA","B1B1A0",1170,0,"Lethal(3)malignant brain tumor-like protein 4",".",".",".",".","pfam02820","MBT","mbt repeat. The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.",".",".",".",".","."]
["ENSRNOG00000050997",1631,104.9229447,767,49.51894636,2.11884445,1.08327768,{"v":1.51159e-70,"d":"1.51E-70"},{"v":6.67168e-70,"d":"6.67E-70"},"up","yes","Ifrd1","protein_coding","chr6:57269384-57288990:-","gi|672056015|ref|XP_008762865.1|",2420,0,"PREDICTED: interferon-related developmental regulator 1 isoform X1 [Rattus norvegicus]","gi|672056014|ref|XM_008764643.1|",2350,0,"PREDICTED: Rattus norvegicus interferon-related developmental regulator 1 (Ifrd1), transcript variant X1, mRNA","P20695",864,0,"Interferon-related developmental regulator 1",".",".",".",".","pfam05004","IFRD","Interferon-related developmental regulator (IFRD). Interferon-related developmental regulator (IFRD1) is the human homologue of the rat early response protein PC4 and its murine homologue TIS7. The exact function of IFRD1 is unknown but it has been shown that PC4 is necessary to muscle differentiation and that it might have a role in signal transduction. This family also contains IFRD2 and its murine equivalent SKMc15 which are highly expressed soon after gastrulation and in the hepatic primordium, suggesting an involvement in early hematopoiesis.","GO:0007405|neuroblast proliferation;GO:0014009|glial cell proliferation;GO:0014706|striated muscle tissue development;GO:0030517|negative regulation of axon extension;GO:0042692|muscle cell differentiation;GO:0043403|skeletal muscle tissue regeneration;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048671|negative regulation of collateral sprouting;GO:0051091|positive regulation of DNA-binding transcription factor activity;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;","GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;",".","."]
["ENSRNOG00000007637",727,46.76822856,202,13.04149565,3.586109279,1.842419452,{"v":6.2269e-70,"d":"6.23E-70"},{"v":2.72311E-69,"d":"2.72E-69"},"up","yes","Acer2","protein_coding","chr5:101391885-101442614:+","gi|157817955|ref|NP_001101413.1|",1444,0,"alkaline ceramidase 2 [Rattus norvegicus]","gi|157817954|ref|NM_001107943.1|",5147,0,"Rattus norvegicus alkaline ceramidase 2 (Acer2), mRNA","Q8VD53",553,0,"Alkaline ceramidase 2",".",".",".",".","pfam05875","Ceramidase","Ceramidase. This family consists of several ceramidases. Ceramidases are enzymes involved in regulating cellular levels of ceramides, sphingoid bases, and their phosphates, EC:3.5.1.23.","GO:0001953|negative regulation of cell-matrix adhesion;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006974|cellular response to DNA damage stimulus;GO:0008150|biological_process;GO:0008284|positive regulation of cell proliferation;GO:0010506|regulation of autophagy;GO:0010942|positive regulation of cell death;GO:0030330|DNA damage response, signal transduction by p53 class mediator;GO:0032526|response to retinoic acid;GO:0033629|negative regulation of cell adhesion mediated by integrin;GO:0042981|regulation of apoptotic process;GO:0046512|sphingosine biosynthetic process;GO:0046514|ceramide catabolic process;GO:0071466|cellular response to xenobiotic stimulus;GO:0090285|negative regulation of protein glycosylation in Golgi;","GO:0005575|cellular_component;GO:0005794|Golgi apparatus;GO:0030173|integral component of Golgi membrane;","GO:0003674|molecular_function;GO:0017040|N-acylsphingosine amidohydrolase activity;GO:0071633|dihydroceramidase activity;GO:0102121|ceramidase activity;","K01441","ACER1_2, ASAH3; alkaline ceramidase [EC:3.5.1.23]"]
["ENSRNOG00000012333",548,35.25308013,112,7.230928281,4.875318735,2.285496542,{"v":1.40642e-69,"d":"1.41E-69"},{"v":6.11767E-69,"d":"6.12E-69"},"up","yes","Kbtbd11","protein_coding","chr16:74615792-74637736:-","gi|157823615|ref|NP_001100796.1|",2673,0,"kelch repeat and BTB domain-containing protein 11 [Rattus norvegicus]","gi|672080533|ref|XM_006253392.2|",4848,0,"PREDICTED: Rattus norvegicus kelch repeat and BTB (POZ) domain containing 11 (Kbtbd11), transcript variant X4, mRNA","Q8BNW9",1004,0,"Kelch repeat and BTB domain-containing protein 11",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.",".",".",".","K10476","KBTBD11; kelch repeat and BTB domain-containing protein 11"]
["ENSRNOG00000015787",1774,114.1221973,872,56.29794162,2.027111366,1.01942535,{"v":1.67478E-69,"d":"1.67E-69"},{"v":7.26286e-69,"d":"7.26E-69"},"up","yes","P3h4","protein_coding","chr10:85338161-85345093:-","gi|817471853|ref|NP_067592.2|",1899,0,"synaptonemal complex protein SC65 precursor [Rattus norvegicus]","gi|817471852|ref|NM_021581.2|",2411,0,"Rattus norvegicus prolyl 3-hydroxylase family member 4 (P3h4), mRNA","Q64375",736,0,"Endoplasmic reticulum protein SC65",".",".",".",".","pfam13525","YfiO","Outer membrane lipoprotein. This outer membrane lipoprotein carries a TPR-like region towards its N-terminal. YfiO in E.coli is one of three outer membrane lipoproteins that form a multicomponent YaeT complex in the outer membrane of Gram-negative bacteria that is involved in the targeting and folding of beta-barrel outer membrane proteins. YfiO is the only essential lipoprotein component of the complex. It is required for the proper assembly and/or targeting of outer membrane proteins to the outer membrane. Through its interactions with NlpB it maintains the functional integrity of the YaeT complex.","GO:0017185|peptidyl-lysine hydroxylation;GO:0030199|collagen fibril organization;GO:0032964|collagen biosynthetic process;GO:0046849|bone remodeling;","GO:0000795|synaptonemal complex;GO:0005783|endoplasmic reticulum;GO:0043231|intracellular membrane-bounded organelle;GO:1902494|catalytic complex;","GO:0005518|collagen binding;","K22461","P3H4; endoplasmic reticulum protein SC65"]
["ENSRNOG00000017858",996,64.07311643,359,23.17770762,2.76442854,1.466981279,{"v":3.35077e-69,"d":"3.35E-69"},{"v":1.44432e-68,"d":"1.44E-68"},"up","yes","Tsr3","protein_coding","chr10:14257171-14259561:+","gi|564371036|ref|XP_006246058.1|",1492,0,"PREDICTED: ribosome biogenesis protein TSR3 homolog isoform X1 [Rattus norvegicus]","gi|672066937|ref|XM_006245996.2|",1173,0,"PREDICTED: Rattus norvegicus TSR3, 20S rRNA accumulation (Tsr3), transcript variant X1, mRNA","Q5HZH2",528,0,"Ribosome biogenesis protein TSR3 homolog","YOR006c",206,{"v":1E-61,"d":"1.00E-61"},"COG2042","pfam04034","DUF367","Domain of unknown function (DUF367).","GO:0000455|enzyme-directed rRNA pseudouridine synthesis;GO:0030490|maturation of SSU-rRNA;","GO:0005737|cytoplasm;","GO:0016740|transferase activity;GO:1904047|S-adenosyl-L-methionine binding;","K09140","TSR3; pre-rRNA-processing protein TSR3"]
["ENSRNOG00000028368",791,50.8853766,240,15.49484632,3.284019445,1.71546267,{"v":5.87234e-69,"d":"5.87E-69"},{"v":2.52361e-68,"d":"2.52E-68"},"up","yes","Etnk2","protein_coding","chr13:44811015-44829037:+","gi|157820655|ref|NP_001101813.1|",861,{"v":6e-113,"d":"6.00E-113"},"ethanolamine kinase 2 [Rattus norvegicus]","gi|157820654|ref|NM_001108343.1|",844,0,"Rattus norvegicus ethanolamine kinase 2 (Etnk2), mRNA","D3ZRW8",335,{"v":9e-111,"d":"9.00E-111"},"Ethanolamine kinase 2","SPAC13G7.12c",51.2,3e-06,"COG0510","pfam01633","Choline_kinase","Choline/ethanolamine kinase. Choline kinase catalyses the committed step in the synthesis of phosphatidylcholine by the CDP-choline pathway. This alignment covers the protein kinase portion of the protein. The divergence of this family makes it very difficult to create a model that specifically predicts choline/ethanolamine kinases only.","GO:0001701|in utero embryonic development;GO:0001890|placenta development;GO:0006646|phosphatidylethanolamine biosynthetic process;GO:0009791|post-embryonic development;GO:0016310|phosphorylation;GO:0035264|multicellular organism growth;","GO:0005737|cytoplasm;","GO:0004305|ethanolamine kinase activity;GO:0005524|ATP binding;","K00894","ETNK, EKI; ethanolamine kinase [EC:2.7.1.82]"]
["ENSRNOG00000008432",824,53.00828106,259,16.72152165,3.170063238,1.66451162,{"v":7.71705e-69,"d":"7.72E-69"},{"v":3.31138e-68,"d":"3.31E-68"},"up","yes","Slc22a5","protein_coding","chr10:38008311-38035309:-","gi|9507119|ref|NP_062142.1|",2760,0,"solute carrier family 22 member 5 [Rattus norvegicus]","gi|9507118|ref|NM_019269.1|",3017,0,"Rattus norvegicus solute carrier family 22 (organic cation/carnitine transporter), member 5 (Slc22a5), mRNA","O70594",1065,0,"Solute carrier family 22 member 5",".",".",".",".","pfam00083","Sugar_tr","Sugar (and other) transporter.","GO:0006814|sodium ion transport;GO:0007005|mitochondrion organization;GO:0007512|adult heart development;GO:0007626|locomotory behavior;GO:0009437|carnitine metabolic process;GO:0009609|response to symbiotic bacterium;GO:0015697|quaternary ammonium group transport;GO:0015879|carnitine transport;GO:0048608|reproductive structure development;GO:0055085|transmembrane transport;GO:0060731|positive regulation of intestinal epithelial structure maintenance;GO:0070715|sodium-dependent organic cation transport;GO:1902270|(R)-carnitine transmembrane transport;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0031231|intrinsic component of peroxisomal membrane;GO:0031526|brush border membrane;","GO:0005524|ATP binding;GO:0015226|carnitine transmembrane transporter activity;GO:0015293|symporter activity;GO:0015651|quaternary ammonium group transmembrane transporter activity;GO:0022857|transmembrane transporter activity;GO:0030165|PDZ domain binding;GO:1901235|(R)-carnitine transmembrane transporter activity;","K08202","SLC22A4_5, OCTN; MFS transporter, OCT family, solute carrier family 22 (organic cation transporter), member 4/5"]
["ENSRNOG00000010150",1276,82.08563912,537,34.66971863,2.367646533,1.243453716,{"v":7.73126e-69,"d":"7.73E-69"},{"v":3.31499E-68,"d":"3.31E-68"},"up","yes","Strbp","protein_coding","chr3:21337855-21414949:-","gi|132626573|ref|NP_445868.2|",3188,0,"spermatid perinuclear RNA-binding protein [Rattus norvegicus]","gi|672045354|ref|XR_591456.1|",3065,0,"PREDICTED: Rattus norvegicus spermatid perinuclear RNA binding protein (Strbp), transcript variant X3, misc_RNA","Q91WM1",1229,0,"Spermatid perinuclear RNA-binding protein",".",".",".",".","pfam07528","DZF","DZF domain. The function of this domain is unknown. It is often found associated with pfam00098 or pfam00035. This domain has been predicted to belong to the nucleotidyltransferase superfamily.","GO:0007283|spermatogenesis;GO:0007286|spermatid development;GO:0007638|mechanosensory behavior;GO:0030154|cell differentiation;","GO:0002177|manchette;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0015630|microtubule cytoskeleton;","GO:0003677|DNA binding;GO:0003723|RNA binding;GO:0003725|double-stranded RNA binding;GO:0003727|single-stranded RNA binding;GO:0008017|microtubule binding;GO:0015631|tubulin binding;","K13200","STRBP; spermatid perinuclear RNA-binding protein"]
["ENSRNOG00000001198",610,39.24156729,144,9.29690779,4.220926805,2.077559812,{"v":8.39914E-69,"d":"8.40E-69"},{"v":3.59866e-68,"d":"3.60E-68"},"up","yes","Fam222a","protein_coding","chr12:41986780-42033682:-","gi|672073386|ref|XP_008767574.1|",1932,0,"PREDICTED: protein FAM222A isoform X2 [Rattus norvegicus]","gi|238683736|gb|AC095845.8|",2278,0,"Rattus norvegicus CH230-10C24 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam15258","FAM222A","Protein family of FAM222A. This protein family, FAM222A are a domain of unknown function. This family of proteins is found in eukaryotes and are typically between 411 and 562 amino acids in length. In humans, the gene encoding this protein domain lies in the position, chromosome 12 open reading frame 34.",".",".",".",".","."]
["ENSRNOG00000028512",1409,90.6415874,626,40.41572414,2.242730752,1.16525643,{"v":1.35504E-68,"d":"1.36E-68"},{"v":5.79273e-68,"d":"5.79E-68"},"up","yes","Ilvbl","protein_coding","chr7:11039871-11049924:-","gi|157823815|ref|NP_001102208.1|",3248,0,"acetolactate synthase-like protein [Rattus norvegicus]","gi|157823814|ref|NM_001108738.1|",2632,0,"Rattus norvegicus ilvB (bacterial acetolactate synthase)-like (Ilvbl), mRNA","Q8BU33",1134,0,"Acetolactate synthase-like protein","ML2083",228,{"v":6e-64,"d":"6.00E-64"},"COG0028","pfam02776","TPP_enzyme_N","Thiamine pyrophosphate enzyme, N-terminal TPP binding domain.","GO:0001561|fatty acid alpha-oxidation;GO:0009097|isoleucine biosynthetic process;GO:0009099|valine biosynthetic process;","GO:0005789|endoplasmic reticulum membrane;GO:0005948|acetolactate synthase complex;GO:0016021|integral component of membrane;","GO:0000287|magnesium ion binding;GO:0003984|acetolactate synthase activity;GO:0030976|thiamine pyrophosphate binding;GO:0050660|flavin adenine dinucleotide binding;","K11259","ILVBL, HACL2; 2-hydroxyacyl-CoA lyase [EC:4.1.2.-]"]
["ENSRNOG00000006628",873,56.16047254,289,18.65837744,3.009933351,1.589731542,{"v":2.73987e-68,"d":"2.74E-68"},{"v":1.16778E-67,"d":"1.17E-67"},"up","yes","Dusp16","protein_coding","chr4:167548155-167629980:-","gi|157820069|ref|NP_001100094.1|",3475,0,"dual specificity protein phosphatase 16 [Rattus norvegicus]","gi|672051366|ref|XM_008763374.1|",3583,0,"PREDICTED: Rattus norvegicus dual specificity phosphatase 16 (Dusp16), transcript variant X1, mRNA","Q9BY84",1198,0,"Dual specificity protein phosphatase 16","SPBC17A3.06",91.3,{"v":1e-18,"d":"1.00E-18"},"COG2453","pfam00782","DSPc","Dual specificity phosphatase, catalytic domain. Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a \"recognition\" region.","GO:0008150|biological_process;GO:0016311|dephosphorylation;GO:0043409|negative regulation of MAPK cascade;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0003674|molecular_function;GO:0004721|phosphoprotein phosphatase activity;GO:0004725|protein tyrosine phosphatase activity;GO:0008330|protein tyrosine/threonine phosphatase activity;GO:0016791|phosphatase activity;GO:0017017|MAP kinase tyrosine/serine/threonine phosphatase activity;","K04459","DUSP, MKP; dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48]"]
["ENSRNOG00000019549",1328,85.43082191,575,37.1230693,2.301286599,1.202440666,{"v":5.59754e-68,"d":"5.60E-68"},{"v":2.37161e-67,"d":"2.37E-67"},"up","yes","Akap12","protein_coding","chr1:40730123-40819886:+","gi|1589163|prf||2210332A",6319,0,"protein kinase C-binding protein","gi|672034210|ref|XM_006227848.2|",6431,0,"PREDICTED: Rattus norvegicus A kinase (PRKA) anchor protein 12 (Akap12), transcript variant X2, mRNA","Q5QD51",2433,0,"A-kinase anchor protein 12",".",".",".",".","pfam03832","WSK","WSK motif. This short motif is names after three conserved residues found in a WXSXK motif in protein kinase A anchoring proteins.","GO:0007165|signal transduction;GO:0007193|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0010738|regulation of protein kinase A signaling;GO:0010739|positive regulation of protein kinase A signaling;GO:0032496|response to lipopolysaccharide;GO:0032760|positive regulation of tumor necrosis factor production;GO:0035733|hepatic stellate cell activation;GO:0043116|negative regulation of vascular permeability;GO:0050804|modulation of chemical synaptic transmission;GO:0051602|response to electrical stimulus;GO:0051770|positive regulation of nitric-oxide synthase biosynthetic process;GO:0061870|positive regulation of hepatic stellate cell migration;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0090036|regulation of protein kinase C signaling;GO:1900143|positive regulation of oligodendrocyte apoptotic process;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0043025|neuronal cell body;GO:0098685|Schaffer collateral - CA1 synapse;","GO:0005516|calmodulin binding;GO:0008179|adenylate cyclase binding;GO:0051018|protein kinase A binding;","K16528","AKAP12; A-kinase anchor protein 12"]
["ENSRNOG00000028208",1282,82.47162175,546,35.25077537,2.339569013,1.226242786,{"v":1.07603E-67,"d":"1.08E-67"},{"v":4.5388e-67,"d":"4.54E-67"},"up","yes","Mief2","protein_coding","chr10:45408082-45414144:+","gi|293340128|ref|XP_001077609.2|",2049,0,"PREDICTED: mitochondrial dynamics protein MID49 [Rattus norvegicus]","gi|672068143|ref|XM_006246545.2|",2650,0,"PREDICTED: Rattus norvegicus mitochondrial elongation factor 2 (Mief2), transcript variant X4, mRNA","Q5NCS9",716,0,"Mitochondrial dynamics protein MID49",".",".",".",".","pfam03281","Mab-21","Mab-21 protein. This family contains Mab-21 and Mab-21 like proteins. In C. elegans these proteins are required for several aspects of embryonic development.","GO:0003374|dynamin family protein polymerization involved in mitochondrial fission;GO:0007005|mitochondrion organization;GO:0008150|biological_process;GO:0010821|regulation of mitochondrion organization;GO:0090141|positive regulation of mitochondrial fission;GO:0090314|positive regulation of protein targeting to membrane;","GO:0005575|cellular_component;GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;","GO:0003674|molecular_function;","K23507","MIEF1_2; mitochondrial dynamics protein MID51/49"]
["ENSRNOG00000006615",1244,80.0270651,523,33.7658526,2.370059067,1.244923015,{"v":2.79998e-67,"d":"2.80E-67"},{"v":1.17412E-66,"d":"1.17E-66"},"up","yes","Mtap","protein_coding","chr5:103873020-103939406:+","gi|148699009|gb|EDL30956.1|",1559,0,"methylthioadenosine phosphorylase, isoform CRA_b, partial [Mus musculus]","gi|672053093|ref|XM_006238382.2|",1695,0,"PREDICTED: Rattus norvegicus methylthioadenosine phosphorylase (Mtap), transcript variant X1, mRNA","Q9CQ65",578,0,"S-methyl-5'-thioadenosine phosphorylase","PAB2264",245,{"v":1e-75,"d":"1.00E-75"},"COG0005","pfam01048","PNP_UDP_1","Phosphorylase superfamily. Members of this family include: purine nucleoside phosphorylase (PNP) Uridine phosphorylase (UdRPase) 5'-methylthioadenosine phosphorylase (MTA phosphorylase)","GO:0006166|purine ribonucleoside salvage;GO:0019509|L-methionine salvage from methylthioadenosine;GO:0032259|methylation;GO:0033574|response to testosterone;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0017061|S-methyl-5-thioadenosine phosphorylase activity;","K00772","mtaP, MTAP; 5'-methylthioadenosine phosphorylase [EC:2.4.2.28]"]
["ENSRNOG00000003984",434,27.91941017,66,4.261082737,6.552186825,2.711976494,{"v":5.35872e-67,"d":"5.36E-67"},{"v":2.23887e-66,"d":"2.24E-66"},"up","yes","ENSRNOG00000003984","lncRNA","chrX:127203823-127213391:-","gi|149060088|gb|EDM10904.1|",619,{"v":1e-71,"d":"1.00E-71"},"apelin, AGTRL1 ligand [Rattus norvegicus]","gi|398650649|ref|NM_031612.3|",3080,0,"Rattus norvegicus apelin (Apln), mRNA","Q9R0R3",116,{"v":9e-29,"d":"9.00E-29"},"Apelin",".",".",".",".","pfam15360","Apelin","APJ endogenous ligand. Apelin is among the most potent stimulators of cardiac contractility known. The apelin-APJ signaling pathway is an important novel mediator of cardiovascular control. Apelin is an adipokine secreted by adipocytes where it is co-expressed with apelin receptor (APJ) in adipocytes. It suppresses adipogenesis through MAPK kinase/ERK dependent pathways and prevents lipid droplet fragmentation, thereby inhibiting basal lipolysis through AMP kinase dependent enhancement of perilipin expression. It also inhibits hormone-stimulated acute lipolysis through decreasing perilipin phosphorylation. Apelin induces a decrease of free fatty acid release via its dual inhibition on adipogenesis and lipolysis. As a vaso-active and vascular cell growth-regulating peptide Apelin is a target of the BMP pathway, the TGF-beta/bone morphogenic protein (BMP) system - a major pathway for angiogenesis.","GO:0001525|angiogenesis;GO:0002026|regulation of the force of heart contraction;GO:0003085|negative regulation of systemic arterial blood pressure;GO:0007369|gastrulation;GO:0007631|feeding behavior;GO:0008284|positive regulation of cell proliferation;GO:0010460|positive regulation of heart rate;GO:0010629|negative regulation of gene expression;GO:0031652|positive regulation of heat generation;GO:0040037|negative regulation of fibroblast growth factor receptor signaling pathway;GO:0042327|positive regulation of phosphorylation;GO:0042756|drinking behavior;GO:0045776|negative regulation of blood pressure;GO:0045823|positive regulation of heart contraction;GO:0045906|negative regulation of vasoconstriction;GO:0050878|regulation of body fluid levels;GO:0051461|positive regulation of corticotropin secretion;GO:0051466|positive regulation of corticotropin-releasing hormone secretion;GO:0060183|apelin receptor signaling pathway;GO:0060976|coronary vasculature development;GO:1902895|positive regulation of pri-miRNA transcription by RNA polymerase II;GO:1904022|positive regulation of G protein-coupled receptor internalization;GO:1904706|negative regulation of vascular smooth muscle cell proliferation;GO:1905564|positive regulation of vascular endothelial cell proliferation;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0048471|perinuclear region of cytoplasm;","GO:0005179|hormone activity;GO:0031704|apelin receptor binding;GO:0042802|identical protein binding;","K05225","APLN; apelin"]
["ENSRNOG00000010558",936,60.21329014,331,21.36997555,2.817658355,1.494496693,{"v":6.44788E-67,"d":"6.45E-67"},{"v":2.68998e-66,"d":"2.69E-66"},"up","yes","Ppif","protein_coding","chr16:1257106-1263913:+","gi|26892289|ref|NP_758443.1|",896,{"v":5e-115,"d":"5.00E-115"},"peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor [Rattus norvegicus]","gi|56268805|gb|BC086977.1|",1508,0,"Rattus norvegicus peptidylprolyl isomerase F (cyclophilin F), mRNA (cDNA clone MGC:93084 IMAGE:7193156), complete cds","P29117",349,{"v":2E-116,"d":"2.00E-116"},"Peptidyl-prolyl cis-trans isomerase F, mitochondrial","SPBC28F2.03",231,{"v":4e-72,"d":"4.00E-72"},"COG0652","pfam00160","Pro_isomerase","Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD. The peptidyl-prolyl cis-trans isomerases, also known as cyclophilins, share this domain of about 109 amino acids. Cyclophilins have been found in all organisms studied so far and catalyse peptidyl-prolyl isomerization during which the peptide bond preceding proline (the peptidyl-prolyl bond) is stabilized in the cis conformation. Mammalian cyclophilin A (CypA) is a major cellular target for the immunosuppressive drug cyclosporin A (CsA). Other roles for cyclophilins may include chaperone and cell signalling function.","GO:0000413|protein peptidyl-prolyl isomerization;GO:0002931|response to ischemia;GO:0006457|protein folding;GO:0006979|response to oxidative stress;GO:0008637|apoptotic mitochondrial changes;GO:0010849|regulation of proton-transporting ATPase activity, rotational mechanism;GO:0010939|regulation of necrotic cell death;GO:0032780|negative regulation of ATPase activity;GO:0042981|regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0046902|regulation of mitochondrial membrane permeability;GO:0070266|necroptotic process;GO:0070301|cellular response to hydrogen peroxide;GO:0071243|cellular response to arsenic-containing substance;GO:0071277|cellular response to calcium ion;GO:0090200|positive regulation of release of cytochrome c from mitochondria;GO:0090201|negative regulation of release of cytochrome c from mitochondria;GO:0090324|negative regulation of oxidative phosphorylation;GO:1902445|regulation of mitochondrial membrane permeability involved in programmed necrotic cell death;GO:1902686|mitochondrial outer membrane permeabilization involved in programmed cell death;GO:2000276|negative regulation of oxidative phosphorylation uncoupler activity;GO:2001243|negative regulation of intrinsic apoptotic signaling pathway;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0005757|mitochondrial permeability transition pore complex;GO:0005759|mitochondrial matrix;GO:0043231|intracellular membrane-bounded organelle;","GO:0003755|peptidyl-prolyl cis-trans isomerase activity;GO:0005515|protein binding;GO:0016018|cyclosporin A binding;GO:0042277|peptide binding;","K09565","PPIF; peptidyl-prolyl isomerase F (cyclophilin D) [EC:5.2.1.8]"]
["ENSRNOG00000008712",1293,83.17925657,557,35.96095583,2.31304354,1.209792423,{"v":7.36356e-67,"d":"7.36E-67"},{"v":3.06528e-66,"d":"3.07E-66"},"up","yes","Tmem268","protein_coding","chr5:76977310-77001452:+","gi|157820875|ref|NP_001100131.1|",1627,0,"transmembrane protein C9orf91 homolog [Rattus norvegicus]","gi|157820874|ref|NM_001106661.1|",3795,0,"Rattus norvegicus similar to RIKEN cDNA 6330416G13 gene (RGD1304595), mRNA","Q8R239",606,0,"Transmembrane protein 268",".",".",".",".","pfam14800","DUF4481","Domain of unknown function (DUF4481).",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000010161",1649,106.0808926,799,51.58492586,2.056432006,1.040143371,{"v":7.54358e-67,"d":"7.54E-67"},{"v":3.13792e-66,"d":"3.14E-66"},"up","yes","Myo10","protein_coding","chr2:76100987-76303030:+","gi|380876953|sp|D3ZJP6.1|MYO10_RAT",10399,0,"RecName: Full=Unconventional myosin-X; AltName: Full=Unconventional myosin-10","gi|157821146|ref|NM_001107657.1|",6833,0,"Rattus norvegicus myosin X (Myo10), mRNA","D3ZJP6",4011,0,"Unconventional myosin-X","YOR326w",532,{"v":9E-157,"d":"9.00E-157"},"COG5022","pfam00063","Myosin_head","Myosin head (motor domain).","GO:0007165|signal transduction;GO:0008360|regulation of cell shape;GO:0022409|positive regulation of cell-cell adhesion;GO:0030705|cytoskeleton-dependent intracellular transport;GO:0051489|regulation of filopodium assembly;","GO:0001726|ruffle;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005938|cell cortex;GO:0016459|myosin complex;GO:0030027|lamellipodium;GO:0030175|filopodium;GO:0031527|filopodium membrane;GO:0032433|filopodium tip;GO:0043005|neuron projection;GO:0043025|neuronal cell body;","GO:0000146|microfilament motor activity;GO:0003774|motor activity;GO:0003779|actin binding;GO:0005516|calmodulin binding;GO:0005524|ATP binding;GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;GO:0030507|spectrin binding;GO:0051015|actin filament binding;GO:0060002|plus-end directed microfilament motor activity;","K12559","MYO10; myosin X"]
["ENSRNOG00000006368",1029,66.19602089,388,25.05000155,2.642555561,1.401933805,{"v":7.5592e-67,"d":"7.56E-67"},{"v":3.14214e-66,"d":"3.14E-66"},"up","yes","Lrrn3","protein_coding","chr6:58489010-58520330:-","gi|51980290|gb|AAH81791.1|",3594,0,"Leucine rich repeat neuronal 3 [Rattus norvegicus]","gi|13540674|ref|NM_030856.1|",3032,0,"Rattus norvegicus leucine rich repeat neuronal 3 (Lrrn3), mRNA","Q9ESY6",1382,0,"Leucine-rich repeat neuronal protein 3","alr0124_1",58.5,8e-08,"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0001934|positive regulation of protein phosphorylation;GO:0051965|positive regulation of synapse assembly;","GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030131|clathrin adaptor complex;GO:0031012|extracellular matrix;","GO:0044877|protein-containing complex binding;","K24492","LRRN1_2_3; leucine-rich repeat neuronal protein 1/2/3"]
["ENSRNOG00000008146",918,59.05534225,321,20.72435695,2.849562107,1.510740237,{"v":1.0767E-66,"d":"1.08E-66"},{"v":4.45931e-66,"d":"4.46E-66"},"up","yes","Tox2","protein_coding","chr3:151853294-151980749:+","gi|564344383|ref|XP_006235640.1|",1713,0,"PREDICTED: TOX high mobility group box family member 2 isoform X1 [Rattus norvegicus]","gi|672048111|ref|XM_006235578.2|",2238,0,"PREDICTED: Rattus norvegicus TOX high mobility group box family member 2 (Tox2), transcript variant X1, mRNA","Q76IQ7",555,0,"TOX high mobility group box family member 2",".",".",".",".","pfam00505","HMG_box","HMG (high mobility group) box.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0008585|female gonad development;GO:0034698|response to gonadotropin;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;GO:0005654|nucleoplasm;","GO:0003677|DNA binding;GO:0003713|transcription coactivator activity;GO:0031490|chromatin DNA binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;",".","."]
["ENSRNOG00000029861",1334,85.81680454,585,37.7686879,2.272168013,1.184069517,{"v":1.12733E-66,"d":"1.13E-66"},{"v":4.65886e-66,"d":"4.66E-66"},"up","yes","Gsta2","protein_coding","chr8:79184322-79196798:-","gi|51036637|ref|NP_058709.2|",1006,{"v":2e-129,"d":"2.00E-129"},"glutathione S-transferase alpha-1 [Rattus norvegicus]","gi|50927556|gb|BC078706.1|",896,0,"Rattus norvegicus glutathione S-transferase A2, mRNA (cDNA clone MGC:93118 IMAGE:7128611), complete cds","P00502",392,{"v":7e-131,"d":"7.00E-131"},"Glutathione S-transferase alpha-1",".",".",".",".","pfam00043","GST_C","Glutathione S-transferase, C-terminal domain. GST conjugates reduced glutathione to a variety of targets including S-crystallin from squid, the eukaryotic elongation factor 1-gamma, the HSP26 family of stress-related proteins and auxin-regulated proteins in plants. Stringent starvation proteins in Escherichia coli are also included in the alignment but are not known to have GST activity.     The glutathione molecule binds in a cleft between N and C-terminal domains. The catalytically important residues are proposed to reside in the N-terminal domain. In plants, GSTs are encoded by a large gene family (48 GST genes in Arabidopsis) and can be divided into the phi, tau, theta, zeta, and lambda classes.","GO:0006693|prostaglandin metabolic process;GO:0006749|glutathione metabolic process;GO:0006805|xenobiotic metabolic process;GO:0007568|aging;GO:0009617|response to bacterium;GO:0030855|epithelial cell differentiation;GO:0035634|response to stilbenoid;GO:0042178|xenobiotic catabolic process;GO:0098869|cellular oxidant detoxification;GO:1901687|glutathione derivative biosynthetic process;","GO:0005829|cytosol;","GO:0004364|glutathione transferase activity;GO:0004769|steroid delta-isomerase activity;GO:0035731|dinitrosyl-iron complex binding;GO:0042803|protein homodimerization activity;GO:0043295|glutathione binding;","K00799","GST, gst; glutathione S-transferase [EC:2.5.1.18]"]
["ENSRNOG00000020119",1595,102.6070489,763,49.26069892,2.082939365,1.058620842,{"v":1.4739E-66,"d":"1.47E-66"},{"v":6.0867e-66,"d":"6.09E-66"},"up","yes","ENSRNOG00000020119","protein_coding","chr18:28581225-28846211:+","gi|54019428|ref|NP_955799.1|",4598,0,"protocadherin alpha-5 precursor [Rattus norvegicus]","gi|80861399|ref|NM_199505.4|",5384,0,"Rattus norvegicus protocadherin alpha 5 (Pcdha5), mRNA","Q9Y5H7",1507,0,"Protocadherin alpha-5",".",".",".",".","pfam08266","Cadherin_2","Cadherin-like. This cadherin domain is usually the most N-terminal copy of the domain.","GO:0007155|cell adhesion;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007283|spermatogenesis;GO:0007399|nervous system development;GO:0009988|cell-cell recognition;GO:0042476|odontogenesis;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0045202|synapse;","GO:0005509|calcium ion binding;GO:0042802|identical protein binding;","K16493","PCDHA; protocadherin alpha"]
["ENSRNOG00000019931",595,38.27661072,142,9.167784071,4.175121319,2.061818119,{"v":1.60195e-66,"d":"1.60E-66"},{"v":6.60116e-66,"d":"6.60E-66"},"up","yes","Map3k21","protein_coding","chr19:53880238-53913576:+","gi|672085451|ref|XP_008770896.1|",4117,0,"PREDICTED: LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase MLK4 isoform X2 [Rattus norvegicus]","gi|672085450|ref|XM_008772674.1|",5701,0,"PREDICTED: Rattus norvegicus similar to Mixed lineage kinase 4 (RGD1306091), transcript variant X2, mRNA","Q8VDG6",1424,0,"Mitogen-activated protein kinase kinase kinase 21",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0000165|MAPK cascade;GO:0006468|protein phosphorylation;",".","GO:0004672|protein kinase activity;GO:0004706|JUN kinase kinase kinase activity;GO:0004709|MAP kinase kinase kinase activity;GO:0005524|ATP binding;","K17534","MLK4, KIAA1804; mitogen-activated protein kinase kinase kinase MLK4 [EC:2.7.11.25]"]
["ENSRNOG00000008934",1629,104.7942838,787,50.81018355,2.062466153,1.044370444,{"v":1.72906e-66,"d":"1.73E-66"},{"v":7.11471e-66,"d":"7.11E-66"},"up","yes","Tmem65","protein_coding","chr7:90274142-90379474:-","gi|155369672|ref|NP_001094465.1|",1297,{"v":3e-165,"d":"3.00E-165"},"transmembrane protein 65 [Rattus norvegicus]","gi|298894377|emb|FQ224194.1|",2949,0,"Rattus norvegicus TL0ACA74YC22 mRNA sequence","Q4VAE3",418,{"v":1E-134,"d":"1.00E-134"},"Transmembrane protein 65",".",".",".",".","pfam10507","DUF2453","Protein of unknown function (DUF2453). Some members of this family are purported to contain GAF domains but this could not be confirmed. The function is not known. It is likely to be a transmembrane protein.","GO:0003231|cardiac ventricle development;GO:1903779|regulation of cardiac conduction;","GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0005886|plasma membrane;GO:0014704|intercalated disc;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000030862",1630,104.8586142,788,50.87474541,2.061113297,1.04342381,{"v":1.96854e-66,"d":"1.97E-66"},{"v":8.09425e-66,"d":"8.09E-66"},"up","yes","Atp6v1h","protein_coding","chr5:14378257-14537962:-","gi|564350129|ref|XP_006237863.1|",2405,0,"PREDICTED: V-type proton ATPase subunit H isoform X1 [Rattus norvegicus]","gi|672051908|ref|XM_008763524.1|",1623,0,"PREDICTED: Rattus norvegicus ATPase, H+ transporting, lysosomal V1 subunit H (Atp6v1h), transcript variant X4, mRNA","Q8BVE3",925,0,"V-type proton ATPase subunit H","SPAC7D4.10",187,{"v":3e-50,"d":"3.00E-50"},"COG5231","pfam03224","V-ATPase_H_N","V-ATPase subunit H. The yeast Saccharomyces cerevisiae vacuolar H+-ATPase (V-ATPase) is a multisubunit complex responsible for acidifying organelles. It functions as an ATP dependent proton pump that transports protons across a lipid bilayer. This domain corresponds to the N terminal domain of the H subunit of V-ATPase. The N-terminal domain is required for the activation of the complex whereas the C-terminal domain is required for coupling ATP hydrolysis to proton translocation.","GO:0006897|endocytosis;GO:1902600|proton transmembrane transport;","GO:0000221|vacuolar proton-transporting V-type ATPase, V1 domain;","GO:0046961|proton-transporting ATPase activity, rotational mechanism;","K02144","ATPeV1H; V-type H+-transporting ATPase subunit H"]
["ENSRNOG00000028319",907,58.34770743,317,20.46610951,2.850942794,1.511439091,{"v":5.82659e-66,"d":"5.83E-66"},{"v":2.38036e-65,"d":"2.38E-65"},"up","yes","Cryz","protein_coding","chr2:243552119-243579758:+","gi|58865938|ref|NP_001012183.1|",1561,0,"quinone oxidoreductase [Rattus norvegicus]","gi|672044561|ref|XM_006233520.2|",1869,0,"PREDICTED: Rattus norvegicus crystallin, zeta (quinone reductase) (Cryz), transcript variant X1, mRNA","Q6AYT0",605,0,"Quinone oxidoreductase","BH0935",163,{"v":6e-44,"d":"6.00E-44"},"COG0604","pfam00107","ADH_zinc_N","Zinc-binding dehydrogenase.","GO:0008150|biological_process;GO:0042178|xenobiotic catabolic process;GO:0051289|protein homotetramerization;","GO:0005829|cytosol;","GO:0003730|mRNA 3'-UTR binding;GO:0003960|NADPH:quinone reductase activity;GO:0008270|zinc ion binding;GO:0042802|identical protein binding;GO:0070402|NADPH binding;","K00344","qor, CRYZ; NADPH:quinone reductase [EC:1.6.5.5]"]
["ENSRNOG00000037753",429,27.59775798,66,4.261082737,6.476700802,2.695259099,{"v":7.97201e-66,"d":"7.97E-66"},{"v":3.24755e-65,"d":"3.25E-65"},"up","yes","Slc10a2","protein_coding","chr16:84374862-84409475:+","gi|8394281|ref|NP_058918.1|",1734,0,"ileal sodium/bile acid cotransporter [Rattus norvegicus]","gi|15011856|ref|NM_017222.2|",4145,0,"Rattus norvegicus solute carrier family 10 (sodium/bile acid cotransporter), member 2 (Slc10a2), mRNA","Q62633",672,0,"Ileal sodium/bile acid cotransporter","BS_yocS",113,{"v":8e-26,"d":"8.00E-26"},"COG0385","pfam01758","SBF","Sodium Bile acid symporter family. This family consists of Na+/bile acid co-transporters. These transmembrane proteins function in the liver in the uptake of bile acids from portal blood plasma a process mediated by the co-transport of Na+. Also in the family is ARC3 from S. cerevisiae, a putative transmembrane protein involved in resistance to arsenic compounds.","GO:0006814|sodium ion transport;GO:0008206|bile acid metabolic process;GO:0009617|response to bacterium;GO:0015721|bile acid and bile salt transport;GO:0055085|transmembrane transport;","GO:0000502|proteasome complex;GO:0005634|nucleus;GO:0005902|microvillus;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;","GO:0008508|bile acid:sodium symporter activity;","K14342","SLC10A2, ASBT; solute carrier family 10 (sodium/bile acid cotransporter), member 2"]
["ENSRNOG00000007882",339,21.80801854,31,2.001417649,10.89628572,3.445764533,{"v":1.492e-65,"d":"1.49E-65"},{"v":6.05205e-65,"d":"6.05E-65"},"up","yes","Ablim2","protein_coding","chr14:74866281-74990334:-","gi|568934146|ref|XP_006503980.1|",3153,0,"PREDICTED: actin-binding LIM protein 2 isoform X12 [Mus musculus]","gi|568934145|ref|XM_006503917.1|",2311,0,"PREDICTED: Mus musculus actin-binding LIM protein 2 (Ablim2), transcript variant X12, mRNA","Q6KC51",1040,0,"Actin-binding LIM protein 2",".",".",".",".","pfam02209","VHP","Villin headpiece domain.","GO:0006351|transcription, DNA-templated;GO:0030032|lamellipodium assembly;GO:0030036|actin cytoskeleton organization;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005737|cytoplasm;GO:0015629|actin cytoskeleton;GO:0030016|myofibril;","GO:0003779|actin binding;GO:0046872|metal ion binding;GO:0051015|actin filament binding;","K07520","ABLIM; actin-binding LIM protein"]
["ENSRNOG00000047734",1464,94.1797615,683,44.09575014,2.135801323,1.094777451,{"v":1.40695e-64,"d":"1.41E-64"},{"v":5.65086e-64,"d":"5.65E-64"},"up","yes","Chst2","protein_coding","chr8:95959826-95966955:-","gi|149018882|gb|EDL77523.1|",2042,0,"rCG25901 [Rattus norvegicus]","gi|672023187|ref|XM_006226524.2|",4628,0,"PREDICTED: Rattus norvegicus carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 (Chst2), transcript variant X1, mRNA","Q80WV3",788,0,"Carbohydrate sulfotransferase 2",".",".",".",".","pfam00685","Sulfotransfer_1","Sulfotransferase domain.","GO:0005975|carbohydrate metabolic process;GO:0006044|N-acetylglucosamine metabolic process;GO:0006790|sulfur compound metabolic process;GO:1903238|positive regulation of leukocyte tethering or rolling;","GO:0000139|Golgi membrane;GO:0005654|nucleoplasm;GO:0005794|Golgi apparatus;GO:0005802|trans-Golgi network;GO:0005829|cytosol;GO:0016021|integral component of membrane;","GO:0001517|N-acetylglucosamine 6-O-sulfotransferase activity;GO:0008146|sulfotransferase activity;","K04745","CHST2; carbohydrate 6-sulfotransferase 2 [EC:2.8.2.-]"]
["ENSRNOG00000049075",977,62.85083811,365,23.56507877,2.667117675,1.415281479,{"v":1.87516e-64,"d":"1.88E-64"},{"v":7.5261e-64,"d":"7.53E-64"},"up","yes","ENSRNOG00000049075","protein_coding","chr2:91765056-91853773:-","gi|1706754|sp|P55053.3|FABP5_RAT",511,{"v":2e-62,"d":"2.00E-62"},"RecName: Full=Fatty acid-binding protein, epidermal; AltName: Full=Cutaneous fatty acid-binding protein; Short=C-FABP; AltName: Full=DA11; AltName: Full=Epidermal-type fatty acid-binding protein; Short=E-FABP; AltName: Full=Fatty acid-binding protein 5","gi|1836057|gb|S83247.1|",541,0,"DA11=15.2 kDa fatty acid binding protein/FABP/C-FAPB homolog [rats, Sprague-Dawley, sciatic nerve traumatized, dorsal root ganglia, mRNA Partial, 695 nt]","P55053",201,{"v":5e-64,"d":"5.00E-64"},"Fatty acid-binding protein 5",".",".",".",".","pfam06963","FPN1","Ferroportin1 (FPN1). This family represents a conserved region approximately 100 residues long within eukaryotic Ferroportin1 (FPN1), a protein that may play a role in iron export from the cell. This family may represent a number of transmembrane regions in Ferroportin1.","GO:0006006|glucose metabolic process;GO:0006629|lipid metabolic process;GO:0006656|phosphatidylcholine biosynthetic process;GO:0009611|response to wounding;GO:0010829|negative regulation of glucose transmembrane transport;GO:0015909|long-chain fatty acid transport;GO:0031392|regulation of prostaglandin biosynthetic process;GO:0035360|positive regulation of peroxisome proliferator activated receptor signaling pathway;GO:0042593|glucose homeostasis;GO:0051930|regulation of sensory perception of pain;GO:0099178|regulation of retrograde trans-synaptic signaling by endocanabinoid;GO:0120162|positive regulation of cold-induced thermogenesis;GO:1990379|lipid transport across blood brain barrier;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0014069|postsynaptic density;GO:0045202|synapse;","GO:0001972|retinoic acid binding;GO:0005324|long-chain fatty acid transporter activity;GO:0005504|fatty acid binding;GO:0042802|identical protein binding;","K08754","FABP5; fatty acid-binding protein 5, epidermal"]
["ENSRNOG00000010332",1056,67.93294272,416,26.85773362,2.529362443,1.338773782,{"v":5.03334e-64,"d":"5.03E-64"},{"v":2.01028E-63,"d":"2.01E-63"},"up","yes","Nipsnap3b","protein_coding","chr5:67614036-67669700:+","gi|57164107|ref|NP_001009422.1|",1241,{"v":6e-167,"d":"6.00E-167"},"protein NipSnap homolog 3A [Rattus norvegicus]","gi|57164106|ref|NM_001009422.1|",1015,0,"Rattus norvegicus nipsnap homolog 3B (C. elegans) (Nipsnap3b), mRNA","Q9CQE1",444,{"v":2e-153,"d":"2.00E-153"},"Protein NipSnap homolog 3B",".",".",".",".","pfam07978","NIPSNAP","NIPSNAP. Members of this family include many hypothetical proteins. It also includes members of the NIPSNAP family which have putative roles in vesicular transport. This domain is often found in duplicate.",".","GO:0005739|mitochondrion;",".",".","."]
["ENSRNOG00000006539",1024,65.8743687,397,25.63105828,2.570099446,1.361824184,{"v":9.73852e-64,"d":"9.74E-64"},{"v":3.87864e-63,"d":"3.88E-63"},"up","yes","Pex16","protein_coding","chr3:78343164-78353207:+","gi|564341890|ref|XP_006234629.1|",1365,0,"PREDICTED: peroxisomal biogenesis factor 16 isoform X1 [Rattus norvegicus]","gi|672046279|ref|XM_006234567.2|",1131,0,"PREDICTED: Rattus norvegicus peroxisomal biogenesis factor 16 (Pex16), transcript variant X1, mRNA","Q91XC9",510,{"v":4E-176,"d":"4.00E-176"},"Peroxisomal membrane protein PEX16",".",".",".",".","pfam08610","Pex16","Peroxisomal membrane protein (Pex16). Pex16 is a peripheral protein located at the matrix face of the peroxisomal membrane.","GO:0006625|protein targeting to peroxisome;GO:0007031|peroxisome organization;GO:0008150|biological_process;GO:0016557|peroxisome membrane biogenesis;GO:0016558|protein import into peroxisome matrix;GO:0022615|protein to membrane docking;GO:0032581|ER-dependent peroxisome organization;GO:0045046|protein import into peroxisome membrane;GO:0106101|ER-dependent peroxisome localization;","GO:0005777|peroxisome;GO:0005778|peroxisomal membrane;GO:0005779|integral component of peroxisomal membrane;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;","GO:0003674|molecular_function;GO:0008022|protein C-terminus binding;","K13335","PEX16; peroxin-16"]
["ENSRNOG00000006143",1618,104.086649,797,51.45580215,2.022836,1.016379359,{"v":3.00149E-63,"d":"3.00E-63"},{"v":1.18715E-62,"d":"1.19E-62"},"up","yes","Ngly1","protein_coding","chr15:9153738-9204630:-","gi|114152094|sp|Q5XI55.2|NGLY1_RAT",3295,0,"RecName: Full=Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase; Short=PNGase; AltName: Full=N-glycanase 1; AltName: Full=Peptide:N-glycanase","gi|62079006|ref|NM_001014136.1|",2144,0,"Rattus norvegicus N-glycanase 1 (Ngly1), mRNA","Q5XI55",1258,0,"Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase",".",".",".",".","pfam09409","PUB","PUB domain. The PUB (also known as PUG) domain is found in peptide N-glycanase where it functions as a AAA ATPase binding domain. This domain is also found on other proteins linked to the ubiquitin-proteasome system.","GO:0006515|protein quality control for misfolded or incompletely synthesized proteins;GO:0006516|glycoprotein catabolic process;GO:0006517|protein deglycosylation;GO:0071712|ER-associated misfolded protein catabolic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0000224|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity;GO:0046872|metal ion binding;","K01456","E3.5.1.52, NGLY1, PNG1; peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase [EC:3.5.1.52]"]
["ENSRNOG00000063524",857,55.13118552,297,19.17487232,2.875178755,1.523651654,{"v":3.77867e-63,"d":"3.78E-63"},{"v":1.48938E-62,"d":"1.49E-62"},"up","yes","Etfrf1","protein_coding","chr4:178180077-178185258:+","gi|293347175|ref|XP_002726521.1|",432,{"v":7e-49,"d":"7.00E-49"},"PREDICTED: LYR motif-containing protein 5 [Rattus norvegicus]","gi|672018908|ref|XM_002726475.4|",1224,0,"PREDICTED: Rattus norvegicus LYR motif containing 5 (Lyrm5), transcript variant X1, mRNA","Q91V16",167,{"v":5e-49,"d":"5.00E-49"},"Electron transfer flavoprotein regulatory factor 1",".",".",".",".","pfam13232","Complex1_LYR_1","Complex1_LYR-like. This is a family of proteins carrying the LYR motif of family Complex1_LYR, pfam05347, likely to be involved in Fe-S cluster biogenesis in mitochondria.",".",".",".",".","."]
["ENSRNOG00000023187",1126,72.4360734,465,30.02126474,2.41282551,1.270723587,{"v":5.28971e-63,"d":"5.29E-63"},{"v":2.08066e-62,"d":"2.08E-62"},"up","yes","RGD1565685","protein_coding","chrX:10129657-10150900:+","gi|187937148|ref|NP_001119758.2|",1621,0,"uncharacterized protein CXorf38 homolog [Rattus norvegicus]","gi|187937147|ref|NM_001126286.2|",1341,0,"Rattus norvegicus similar to RIKEN cDNA 1810030O07 (RGD1565685), mRNA",".",".",".",".",".",".",".",".","pfam15112","DUF4559","Domain of unknown function (DUF4559). This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. This family includes human protein CXorf38.",".",".",".",".","."]
["ENSRNOG00000007568",1049,67.48262966,417,26.92229548,2.506570427,1.32571477,{"v":1.09301E-62,"d":"1.09E-62"},{"v":4.28158e-62,"d":"4.28E-62"},"up","yes","Spata6","protein_coding","chr5:126593122-126676557:+","gi|404312681|ref|NP_599219.2|",2366,0,"spermatogenesis-associated protein 6 precursor [Rattus norvegicus]","gi|404312680|ref|NM_134392.2|",2368,0,"Rattus norvegicus spermatogenesis associated 6 (Spata6), mRNA","Q99MU5",909,0,"Spermatogenesis-associated protein 6",".",".",".",".","pfam14909","SPATA6","Spermatogenesis-assoc protein 6. This domain family is found in eukaryotes, and is approximately 140 amino acids in length. The family has similarity to the motor domain of kinesin related proteins and with the Caenorhabditis elegans neural calcium sensor protein (NCS###2).","GO:0007283|spermatogenesis;GO:0030154|cell differentiation;GO:0044458|motile cilium assembly;","GO:0005576|extracellular region;GO:0097224|sperm connecting piece;","GO:0032027|myosin light chain binding;","K23224","SPATA6; spermatogenesis-associated protein 6"]
["ENSRNOG00000005670",455,29.27034937,84,5.423196211,5.397250668,2.432224693,{"v":2.23042e-62,"d":"2.23E-62"},{"v":8.68346e-62,"d":"8.68E-62"},"up","yes","Art4","protein_coding","chr4:169740331-169750665:-","gi|291042681|ref|NP_001166980.1|",1478,0,"ecto-ADP-ribosyltransferase 4 precursor [Rattus norvegicus]","gi|291042680|ref|NM_001173509.1|",2436,0,"Rattus norvegicus ADP-ribosyltransferase 4 (Art4), mRNA","Q9CRA0",494,{"v":8e-168,"d":"8.00E-168"},"Ecto-ADP-ribosyltransferase 4",".",".",".",".","pfam01129","ART","NAD:arginine ADP-ribosyltransferase.","GO:0018120|peptidyl-arginine ADP-ribosylation;",".","GO:0003950|NAD+ ADP-ribosyltransferase activity;","K06717","ART4, DO, CD297; ADP-ribosyltransferase 4 [EC:2.4.2.31]"]
["ENSRNOG00000029370",532,34.22379311,121,7.811985018,4.3809343,2.131238579,{"v":3.65164e-62,"d":"3.65E-62"},{"v":1.41972e-61,"d":"1.42E-61"},"up","yes","Abhd3","protein_coding","chr18:1720718-1803428:-","gi|157820211|ref|NP_001099632.1|",2088,0,"abhydrolase domain-containing protein 3 [Rattus norvegicus]","gi|157820210|ref|NM_001106162.1|",1912,0,"Rattus norvegicus abhydrolase domain containing 3 (Abhd3), mRNA","Q91ZH7",786,0,"Phospholipase ABHD3","PA0368",130,{"v":1e-31,"d":"1.00E-31"},"COG0429","pfam06701","MIB_HERC2","Mib_herc2. Named \"mib/herc2 domain\" in. Usually the protein also contains an E3 ligase domain (either Ring or Hect).","GO:0008150|biological_process;GO:0044255|cellular lipid metabolic process;GO:0046470|phosphatidylcholine metabolic process;GO:0051792|medium-chain fatty acid biosynthetic process;GO:0051793|medium-chain fatty acid catabolic process;","GO:0005575|cellular_component;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0004623|phospholipase A2 activity;GO:0008126|acetylesterase activity;GO:0008970|phospholipase A1 activity;GO:0034338|short-chain carboxylesterase activity;GO:0047372|acylglycerol lipase activity;","K13696","ABHD1_3; abhydrolase domain-containing protein 1/3"]
["ENSRNOG00000002693",1288,82.85760438,576,37.18763116,2.228095789,1.155811257,{"v":4.49866e-62,"d":"4.50E-62"},{"v":1.74665e-61,"d":"1.75E-61"},"up","yes","Nme1","protein_coding","chr10:78906083-78916408:-","gi|19924089|ref|NP_612557.1|",808,{"v":1e-101,"d":"1.00E-101"},"nucleoside diphosphate kinase A [Rattus norvegicus]","gi|26330285|dbj|AK034899.1|",728,0,"Mus musculus 12 days embryo embryonic body between diaphragm region and neck cDNA, RIKEN full-length enriched library, clone:9430059B17 product:expressed in non-metastatic cells 1, protein (NM23A) (nucleoside diphosphate kinase), full insert sequence","Q05982",315,{"v":5e-103,"d":"5.00E-103"},"Nucleoside diphosphate kinase A","YKL067w",200,{"v":1E-59,"d":"1.00E-59"},"COG0105","pfam00334","NDK","Nucleoside diphosphate kinase.","GO:0002762|negative regulation of myeloid leukocyte differentiation;GO:0006165|nucleoside diphosphate phosphorylation;GO:0006183|GTP biosynthetic process;GO:0006228|UTP biosynthetic process;GO:0006241|CTP biosynthetic process;GO:0006259|DNA metabolic process;GO:0006897|endocytosis;GO:0007595|lactation;GO:0009410|response to xenobiotic stimulus;GO:0010629|negative regulation of gene expression;GO:0010976|positive regulation of neuron projection development;GO:0014075|response to amine;GO:0021766|hippocampus development;GO:0030154|cell differentiation;GO:0030879|mammary gland development;GO:0033574|response to testosterone;GO:0043388|positive regulation of DNA binding;GO:0050679|positive regulation of epithelial cell proliferation;GO:0051591|response to cAMP;GO:0071333|cellular response to glucose stimulus;GO:0071398|cellular response to fatty acid;GO:0071466|cellular response to xenobiotic stimulus;","GO:0005634|nucleus;GO:0005741|mitochondrial outer membrane;GO:0005813|centrosome;GO:0005829|cytosol;GO:0005882|intermediate filament;GO:0016020|membrane;GO:0032587|ruffle membrane;GO:0048471|perinuclear region of cytoplasm;","GO:0000287|magnesium ion binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0003697|single-stranded DNA binding;GO:0004536|deoxyribonuclease activity;GO:0004550|nucleoside diphosphate kinase activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0005525|GTP binding;GO:0019215|intermediate filament binding;GO:0019899|enzyme binding;GO:0019901|protein kinase binding;GO:0042802|identical protein binding;GO:0043015|gamma-tubulin binding;GO:0043024|ribosomal small subunit binding;","K00940","ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]"]
["ENSRNOG00000022691",318,20.45707934,29,1.87229393,10.92621143,3.449721341,{"v":1.16296E-61,"d":"1.16E-61"},{"v":4.48181e-61,"d":"4.48E-61"},"up","yes","St8sia5","protein_coding","chr18:70736602-70797789:+","gi|564394114|ref|XP_006255030.1|",2193,0,"PREDICTED: alpha-2,8-sialyltransferase 8E isoform X1 [Rattus norvegicus]","gi|672083530|ref|XM_006254968.2|",1785,0,"PREDICTED: Rattus norvegicus ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 (St8sia5), transcript variant X1, mRNA","P70126",832,0,"Alpha-2,8-sialyltransferase 8E",".",".",".",".","pfam00777","Glyco_transf_29","Glycosyltransferase family 29 (sialyltransferase). Members of this family belong to glycosyltransferase family 29.","GO:0006486|protein glycosylation;GO:0006688|glycosphingolipid biosynthetic process;GO:0097503|sialylation;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0003828|alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity;GO:0008373|sialyltransferase activity;","K03369","SIAT8E; alpha-N-acetyl-neuraminate alpha-2,8-sialyltransferase (sialyltransferase 8E) [EC:2.4.99.-]"]
["ENSRNOG00000007447",1098,70.63482113,454,29.31108428,2.409833101,1.268933232,{"v":2.37511e-61,"d":"2.38E-61"},{"v":9.12852e-61,"d":"9.13E-61"},"up","yes","Pla2g4b","protein_coding","chr3:107005489-107013853:+","gi|167900429|ref|NP_001101234.2|",3993,0,"cytosolic phospholipase A2 beta [Rattus norvegicus]","gi|167900428|ref|NM_001107764.2|",2812,0,"Rattus norvegicus phospholipase A2 group IVB (Pla2g4b), mRNA","P0C871",1425,0,"Cytosolic phospholipase A2 beta",".",".",".",".","pfam01735","PLA2_B","Lysophospholipase catalytic domain. This family consists of Lysophospholipase / phospholipase B EC:3.1.1.5 and cytosolic phospholipase A2 EC:3.1.4 which also has a C2 domain pfam00168. Phospholipase B enzymes catalyse the release of fatty acids from lysophsopholipids and are capable in vitro of hydrolysing all phospholipids extractable form yeast cells. Cytosolic phospholipase A2 associates with natural membranes in response to physiological increases in Ca2+ and selectively hydrolyses arachidonyl phospholipids, the aligned region corresponds the the carboxy-terminal Ca2+-independent catalytic domain of the protein as discussed in.","GO:0036151|phosphatidylcholine acyl-chain remodeling;GO:0036152|phosphatidylethanolamine acyl-chain remodeling;GO:0046475|glycerophospholipid catabolic process;","GO:0005743|mitochondrial inner membrane;GO:0005829|cytosol;GO:0031901|early endosome membrane;","GO:0004622|lysophospholipase activity;GO:0004623|phospholipase A2 activity;GO:0005509|calcium ion binding;GO:0005544|calcium-dependent phospholipid binding;GO:0008970|phospholipase A1 activity;GO:0047498|calcium-dependent phospholipase A2 activity;","K16342","PLA2G4, CPLA2; cytosolic phospholipase A2 [EC:3.1.1.4]"]
["ENSRNOG00000045738",598,38.46960203,158,10.20077383,3.771243505,1.915040307,{"v":7.55623E-61,"d":"7.56E-61"},{"v":2.87707E-60,"d":"2.88E-60"},"up","yes","Ak4","protein_coding","chr5:116039616-116098618:+","gi|564351830|ref|XP_006238507.1|",1185,{"v":2e-148,"d":"2.00E-148"},"PREDICTED: adenylate kinase 4, mitochondrial isoform X1 [Rattus norvegicus]","gi|672053113|ref|XM_006238445.2|",3755,0,"PREDICTED: Rattus norvegicus adenylate kinase 4 (Ak4), transcript variant X1, mRNA","Q9WUS0",455,{"v":7e-149,"d":"7.00E-149"},"Adenylate kinase 4, mitochondrial","BH0155",162,{"v":1e-43,"d":"1.00E-43"},"COG0563","pfam00406","ADK","Adenylate kinase.","GO:0001889|liver development;GO:0002082|regulation of oxidative phosphorylation;GO:0006165|nucleoside diphosphate phosphorylation;GO:0006172|ADP biosynthetic process;GO:0007420|brain development;GO:0009142|nucleoside triphosphate biosynthetic process;GO:0009410|response to xenobiotic stimulus;GO:0046033|AMP metabolic process;GO:0046034|ATP metabolic process;GO:0046039|GTP metabolic process;GO:0046940|nucleoside monophosphate phosphorylation;GO:0071456|cellular response to hypoxia;GO:2001169|regulation of ATP biosynthetic process;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005759|mitochondrial matrix;","GO:0003674|molecular_function;GO:0004017|adenylate kinase activity;GO:0004550|nucleoside diphosphate kinase activity;GO:0005524|ATP binding;GO:0005525|GTP binding;GO:0046899|nucleoside triphosphate adenylate kinase activity;","K00939","adk, AK; adenylate kinase [EC:2.7.4.3]"]
["ENSRNOG00000018937",1477,95.0160572,714,46.09716779,2.061212472,1.043493227,{"v":2.2467e-60,"d":"2.25E-60"},{"v":8.4809e-60,"d":"8.48E-60"},"up","yes","Gstm2","protein_coding","chr2:195566701-195572203:-","gi|13592152|ref|NP_112416.1|",1168,{"v":2e-157,"d":"2.00E-157"},"glutathione S-transferase Yb-3 [Rattus norvegicus]","gi|37590780|gb|BC059130.1|",1261,0,"Rattus norvegicus glutathione S-transferase, mu 7, mRNA (cDNA clone MGC:72778 IMAGE:6921477), complete cds","P08009",454,{"v":5e-159,"d":"5.00E-159"},"Glutathione S-transferase Yb-3",".",".",".",".","pfam02798","GST_N","Glutathione S-transferase, N-terminal domain. Function: conjugation of reduced glutathione to a variety of targets. Also included in the alignment, but are not GSTs: * S-crystallins from squid. Similarity to GST previously noted. * Eukaryotic elongation factors 1-gamma. Not known to have GST activity; similarity not previously recognized. * HSP26 family of stress-related proteins. including auxin-regulated proteins in plants and stringent starvation proteins in Escherichia coli. Not known to have GST activity. Similarity not previously recognized. The glutathione molecule binds in a cleft between N and C-terminal domains - the catalytically important residues are proposed to reside in the N-terminal domain.","GO:0006749|glutathione metabolic process;GO:0006805|xenobiotic metabolic process;GO:0007568|aging;GO:0007608|sensory perception of smell;GO:0010038|response to metal ion;GO:0010880|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0014070|response to organic cyclic compound;GO:0018916|nitrobenzene metabolic process;GO:0033595|response to genistein;GO:0042178|xenobiotic catabolic process;GO:0043651|linoleic acid metabolic process;GO:0051122|hepoxilin biosynthetic process;GO:0060315|negative regulation of ryanodine-sensitive calcium-release channel activity;GO:0060316|positive regulation of ryanodine-sensitive calcium-release channel activity;GO:0070458|cellular detoxification of nitrogen compound;GO:0071313|cellular response to caffeine;GO:0098869|cellular oxidant detoxification;GO:1902168|response to catechin;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016529|sarcoplasmic reticulum;GO:0032991|protein-containing complex;GO:0045171|intercellular bridge;","GO:0004364|glutathione transferase activity;GO:0004602|glutathione peroxidase activity;GO:0005102|signaling receptor binding;GO:0005504|fatty acid binding;GO:0019899|enzyme binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0043295|glutathione binding;","K00799","GST, gst; glutathione S-transferase [EC:2.5.1.18]"]
["ENSRNOG00000006302",1339,86.13845673,619,39.96379113,2.155412545,1.107964027,{"v":2.41664E-60,"d":"2.42E-60"},{"v":9.11035e-60,"d":"9.11E-60"},"up","yes","Gclc","protein_coding","chr8:78630127-78668544:+","gi|25742748|ref|NP_036947.1|",3453,0,"glutamate--cysteine ligase catalytic subunit [Rattus norvegicus]","gi|52138588|ref|NM_012815.2|",3045,0,"Rattus norvegicus glutamate-cysteine ligase, catalytic subunit (Gclc), mRNA","P19468",1334,0,"Glutamate--cysteine ligase catalytic subunit",".",".",".",".","pfam03074","GCS","Glutamate-cysteine ligase. This family represents the catalytic subunit of glutamate-cysteine ligase (E.C. 6.3.2.2), also known as gamma-glutamylcysteine synthetase (GCS).  This enzyme catalyses the rate limiting step in the biosynthesis of glutathione. The eukaryotic enzyme is a dimer of a heavy chain and a light chain with all the catalytic activity exhibited by the heavy chain (this family).","GO:0006534|cysteine metabolic process;GO:0006536|glutamate metabolic process;GO:0006749|glutathione metabolic process;GO:0006750|glutathione biosynthetic process;GO:0006979|response to oxidative stress;GO:0007568|aging;GO:0007584|response to nutrient;GO:0009408|response to heat;GO:0009410|response to xenobiotic stimulus;GO:0009725|response to hormone;GO:0010996|response to auditory stimulus;GO:0014823|response to activity;GO:0019852|L-ascorbic acid metabolic process;GO:0031397|negative regulation of protein ubiquitination;GO:0032436|positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032869|cellular response to insulin stimulus;GO:0035729|cellular response to hepatocyte growth factor stimulus;GO:0043066|negative regulation of apoptotic process;GO:0043524|negative regulation of neuron apoptotic process;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0044752|response to human chorionic gonadotropin;GO:0045454|cell redox homeostasis;GO:0045892|negative regulation of transcription, DNA-templated;GO:0046685|response to arsenic-containing substance;GO:0046686|response to cadmium ion;GO:0051409|response to nitrosative stress;GO:0051900|regulation of mitochondrial depolarization;GO:0070555|response to interleukin-1;GO:0071260|cellular response to mechanical stimulus;GO:0071333|cellular response to glucose stimulus;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0097069|cellular response to thyroxine stimulus;GO:0097746|regulation of blood vessel diameter;GO:1901029|negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;GO:2000490|negative regulation of hepatic stellate cell activation;GO:2001237|negative regulation of extrinsic apoptotic signaling pathway;","GO:0005739|mitochondrion;GO:0005829|cytosol;GO:0017109|glutamate-cysteine ligase complex;","GO:0000287|magnesium ion binding;GO:0004357|glutamate-cysteine ligase activity;GO:0005524|ATP binding;GO:0016595|glutamate binding;GO:0043531|ADP binding;GO:0044877|protein-containing complex binding;","K11204","GCLC; glutamate--cysteine ligase catalytic subunit [EC:6.3.2.2]"]
["ENSRNOG00000017762",468,30.10664507,95,6.133376667,4.90865745,2.295328492,{"v":5.45506e-60,"d":"5.46E-60"},{"v":2.04299E-59,"d":"2.04E-59"},"up","yes","Cdhr5","protein_coding","chr1:196373112-196381543:-","gi|19924057|ref|NP_612534.1|",3513,0,"cadherin-related family member 5 precursor [Rattus norvegicus]","gi|71051352|gb|BC098904.1|",2695,0,"Rattus norvegicus mucin and cadherin like, mRNA (cDNA clone MGC:114263 IMAGE:7444666), complete cds","Q9JIK1",1357,0,"Cadherin-related family member 5",".",".",".",".","pfam05109","Herpes_BLLF1","Herpes virus major outer envelope glycoprotein (BLLF1). This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralizing antibodies in vivo.","GO:0007155|cell adhesion;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0030154|cell differentiation;GO:0032532|regulation of microvillus length;GO:0090675|intermicrovillar adhesion;","GO:0005887|integral component of plasma membrane;GO:0005905|clathrin-coated pit;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0031526|brush border membrane;GO:0031528|microvillus membrane;GO:0044214|spanning component of plasma membrane;","GO:0005509|calcium ion binding;GO:0008013|beta-catenin binding;GO:0050839|cell adhesion molecule binding;","K16505","CDHR5, MUCDHL; cadherin-related family member 5"]
["ENSRNOG00000009085",1113,71.5997777,472,30.47319776,2.349598433,1.232414209,{"v":1.82192E-59,"d":"1.82E-59"},{"v":6.80102e-59,"d":"6.80E-59"},"up","yes","Prkag2","protein_coding","chr4:10010890-10252142:+","gi|564345393|ref|XP_006236013.1|",2347,0,"PREDICTED: 5'-AMP-activated protein kinase subunit gamma-2 isoform X3 [Rattus norvegicus]","gi|564345394|ref|XM_006235952.1|",3466,0,"PREDICTED: Rattus norvegicus protein kinase, AMP-activated, gamma 2 non-catalytic subunit (Prkag2), transcript variant X4, mRNA","Q91WG5",887,0,"5'-AMP-activated protein kinase subunit gamma-2","YGL115w",198,{"v":8E-55,"d":"8.00E-55"},"COG0517","pfam00571","CBS","CBS domain. CBS domains are small intracellular modules that pair together to form a stable globular domain. This family represents a single CBS domain. Pairs of these domains have been termed a Bateman domain. CBS domains have been shown to bind ligands with an adenosyl group such as AMP, ATP and S-AdoMet. CBS domains are found attached to a wide range of other protein domains suggesting that CBS domains may play a regulatory role making proteins sensitive to adenosyl carrying ligands. The region containing the CBS domains in Cystathionine-beta synthase is involved in regulation by S-AdoMet. CBS domain pairs from AMPK bind AMP or ATP. The CBS domains from IMPDH and the chloride channel CLC2 bind ATP.","GO:0005977|glycogen metabolic process;GO:0006110|regulation of glycolytic process;GO:0006468|protein phosphorylation;GO:0006469|negative regulation of protein kinase activity;GO:0010800|positive regulation of peptidyl-threonine phosphorylation;GO:0019217|regulation of fatty acid metabolic process;GO:0032147|activation of protein kinase activity;GO:0035556|intracellular signal transduction;GO:0042149|cellular response to glucose starvation;GO:0045860|positive regulation of protein kinase activity;GO:0050790|regulation of catalytic activity;GO:2000480|negative regulation of cAMP-dependent protein kinase activity;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0031588|nucleotide-activated protein kinase complex;","GO:0004679|AMP-activated protein kinase activity;GO:0004862|cAMP-dependent protein kinase inhibitor activity;GO:0005524|ATP binding;GO:0008603|cAMP-dependent protein kinase regulator activity;GO:0008607|phosphorylase kinase regulator activity;GO:0016208|AMP binding;GO:0019887|protein kinase regulator activity;GO:0019901|protein kinase binding;GO:0030295|protein kinase activator activity;GO:0043531|ADP binding;","K07200","PRKAG; 5'-AMP-activated protein kinase, regulatory gamma subunit"]
["ENSRNOG00000021773",1081,69.54120368,452,29.18196056,2.383020275,1.252791226,{"v":2.87334e-59,"d":"2.87E-59"},{"v":1.06979E-58,"d":"1.07E-58"},"up","yes","Bop1","protein_coding","chr7:108172066-108195931:-","gi|66730443|ref|NP_001019421.1|",3330,0,"ribosome biogenesis protein BOP1 [Rattus norvegicus]","gi|66730442|ref|NM_001024250.1|",2381,0,"Rattus norvegicus block of proliferation 1 (Bop1), mRNA","Q562C2",1285,0,"Ribosome biogenesis protein BOP1",".",".",".",".","pfam08145","BOP1NT","BOP1NT (NUC169) domain. This N terminal domain is found in BOP1-like WD40 proteins.","GO:0000027|ribosomal large subunit assembly;GO:0000448|cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000463|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0006364|rRNA processing;GO:0008150|biological_process;GO:0008283|cell proliferation;GO:0042273|ribosomal large subunit biogenesis;GO:0051726|regulation of cell cycle;GO:1901796|regulation of signal transduction by p53 class mediator;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005694|chromosome;GO:0005730|nucleolus;GO:0030687|preribosome, large subunit precursor;GO:0070545|PeBoW complex;GO:1990904|ribonucleoprotein complex;","GO:0003674|molecular_function;GO:0043021|ribonucleoprotein complex binding;","K14824","ERB1, BOP1; ribosome biogenesis protein ERB1"]
["ENSRNOG00000068701",1065,68.51191667,443,28.60090383,2.39544586,1.260294207,{"v":5.99119e-59,"d":"5.99E-59"},{"v":2.21616e-58,"d":"2.22E-58"},"up","yes","ENSRNOG00000068701","lncRNA","chr14:4224146-4226886:+",".",".",".",".","gi|672075437|ref|XM_006250542.2|",2741,0,"PREDICTED: Rattus norvegicus leucine rich repeat containing 8 family, member C (Lrrc8c), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam09416","UPF1_Zn_bind","RNA helicase (UPF2 interacting domain). UPF1 is an essential RNA helicase that detects mRNAs containing premature stop codons and triggers their degradation. This domain contains 3 zinc binding motifs and forms interactions with another protein (UPF2) that is also involved nonsense-mediated mRNA decay (NMD).",".",".",".",".","."]
["ENSRNOG00000019587",1335,85.88113498,625,40.35116228,2.128343525,1.089731028,{"v":1.27283E-58,"d":"1.27E-58"},{"v":4.66893e-58,"d":"4.67E-58"},"up","yes","Ptprn","protein_coding","chr9:76741016-76756190:-","gi|564368872|ref|XP_006245196.1|",4282,0,"PREDICTED: receptor-type tyrosine-protein phosphatase-like N isoform X1 [Rattus norvegicus]","gi|672065437|ref|XM_006245134.2|",3515,0,"PREDICTED: Rattus norvegicus protein tyrosine phosphatase, receptor type, N (Ptprn), transcript variant X1, mRNA","Q63259",1647,0,"Receptor-type tyrosine-protein phosphatase-like N","SPAC26F1.10c",135,{"v":4e-32,"d":"4.00E-32"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0000302|response to reactive oxygen species;GO:0001553|luteinization;GO:0009749|response to glucose;GO:0019221|cytokine-mediated signaling pathway;GO:0019932|second-messenger-mediated signaling;GO:0030073|insulin secretion;GO:0032868|response to insulin;GO:0035773|insulin secretion involved in cellular response to glucose stimulus;GO:0043627|response to estrogen;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051591|response to cAMP;GO:1904692|positive regulation of type B pancreatic cell proliferation;GO:1990502|dense core granule maturation;","GO:0005634|nucleus;GO:0005768|endosome;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030141|secretory granule;GO:0030658|transport vesicle membrane;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0043679|axon terminus;GO:0045202|synapse;","GO:0030507|spectrin binding;GO:0044389|ubiquitin-like protein ligase binding;GO:0051020|GTPase binding;","K07817","PTPRN; receptor-type tyrosine-protein phosphatase N [EC:3.1.3.48]"]
["ENSRNOG00000013884",1083,69.66986455,457,29.50476986,2.361308523,1.239586553,{"v":1.9976E-58,"d":"2.00E-58"},{"v":7.3087E-58,"d":"7.31E-58"},"up","yes","Psd3","protein_coding","chr16:21465639-22034547:+","gi|564318843|ref|XP_006222264.1|",6618,0,"PREDICTED: PH and SEC7 domain-containing protein 3 isoform X1 [Rattus norvegicus]","gi|672029294|ref|XM_006222202.2|",10609,0,"PREDICTED: Rattus norvegicus pleckstrin and Sec7 domain containing 3 (Psd3), transcript variant X1, mRNA","Q2PFD7",1877,0,"PH and SEC7 domain-containing protein 3","YDR170c",108,{"v":3e-22,"d":"3.00E-22"},"COG5307","pfam01369","Sec7","Sec7 domain. The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.","GO:0032012|regulation of ARF protein signal transduction;GO:0050790|regulation of catalytic activity;","GO:0016020|membrane;GO:0032587|ruffle membrane;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0005543|phospholipid binding;","K12494","PSD; PH and SEC7 domain-containing protein"]
["ENSRNOG00000006698",437,28.11240149,84,5.423196211,5.183733059,2.373991427,{"v":2.32202e-58,"d":"2.32E-58"},{"v":8.49025E-58,"d":"8.49E-58"},"up","yes","Rab33a","protein_coding","chrX:127694964-127706378:+","gi|332226374|ref|XP_003262364.1|",1362,0,"PREDICTED: ras-related protein Rab-33A [Nomascus leucogenys]","gi|157818280|ref|NM_001108257.1|",995,0,"Rattus norvegicus RAB33A, member RAS oncogene family (Rab33a), mRNA","Q14088",493,{"v":1E-175,"d":"1.00E-175"},"Ras-related protein Rab-33A",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0019882|antigen processing and presentation;GO:0032482|Rab protein signal transduction;","GO:0005768|endosome;GO:0005794|Golgi apparatus;","GO:0003924|GTPase activity;GO:0005525|GTP binding;","K07919","RAB33A; Ras-related protein Rab-33A"]
["ENSRNOG00000062871",1013,65.16673388,412,26.59948618,2.449924538,1.292737312,{"v":2.35852E-58,"d":"2.36E-58"},{"v":8.61821e-58,"d":"8.62E-58"},"up","yes","ENSRNOG00000062871","lncRNA","chr14:4458688-4487530:+","gi|1791243|gb|AAB41224.1|",471,{"v":3e-101,"d":"3.00E-101"},"ORF2 [Rattus norvegicus]","gi|1213335|gb|U48828.1|RNU48828",3612,0,"Rattus norvegicus retroviral-like ovarian specific transcript 30-1 mRNA","P11369",183,{"v":1E-97,"d":"1.00E-97"},"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam02263","GBP","Guanylate-binding protein, N-terminal domain. Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.",".",".",".",".","."]
["ENSRNOG00000018246",1490,95.8523529,736,47.51752871,2.017199874,1.01235404,{"v":5.07776E-58,"d":"5.08E-58"},{"v":1.84718E-57,"d":"1.85E-57"},"up","yes","Tdp2","protein_coding","chr17:40228947-40240313:-","gi|149031531|gb|EDL86498.1|",1838,0,"similar to putative TRAF and TNF receptor associated protein, isoform CRA_c [Rattus norvegicus]","gi|77917591|ref|NM_001034947.1|",1917,0,"Rattus norvegicus tyrosyl-DNA phosphodiesterase 2 (Tdp2), mRNA","Q3T1H5",709,0,"Tyrosyl-DNA phosphodiesterase 2",".",".",".",".","pfam03372","Exo_endo_phos","Endonuclease/Exonuclease/phosphatase family. This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins EC:4.2.99.18, DNase I proteins EC:3.1.21.1, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56, Sphingomyelinase EC:3.1.4.12 and Nocturnin.","GO:0006302|double-strand break repair;GO:0048666|neuron development;GO:0090305|nucleic acid phosphodiester bond hydrolysis;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0016235|aggresome;GO:0016604|nuclear body;GO:0016605|PML body;","GO:0000287|magnesium ion binding;GO:0003697|single-stranded DNA binding;GO:0004518|nuclease activity;GO:0030145|manganese ion binding;GO:0036317|tyrosyl-RNA phosphodiesterase activity;GO:0070260|5'-tyrosyl-DNA phosphodiesterase activity;","K19619","TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]"]
["ENSRNOG00000042826",614,39.49888905,177,11.42744916,3.456492214,1.789308676,{"v":4.35949e-57,"d":"4.36E-57"},{"v":1.56692E-56,"d":"1.57E-56"},"up","yes","Zfp52","protein_coding","chr1:61335270-61363102:+","gi|62079051|ref|NP_001014180.1|",3913,0,"zinc finger protein 52 [Rattus norvegicus]","gi|62079050|ref|NM_001014158.1|",2385,0,"Rattus norvegicus zinc finger protein 52 (Zfp52), mRNA","Q8TAQ5",621,0,"Zinc finger protein 420",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;",".","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0046872|metal ion binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSRNOG00000015063",1146,73.72268216,505,32.60373913,2.261172618,1.177071132,{"v":5.17549e-57,"d":"5.18E-57"},{"v":1.85671E-56,"d":"1.86E-56"},"up","yes","Dhodh","protein_coding","chr19:37558177-37591654:-","gi|56676360|ref|NP_001008553.1|",1775,0,"dihydroorotate dehydrogenase (quinone), mitochondrial precursor [Rattus norvegicus]","gi|672084936|ref|XR_361830.2|",1380,0,"PREDICTED: Rattus norvegicus dihydroorotate dehydrogenase (quinone) (Dhodh), transcript variant X3, misc_RNA","Q63707",688,0,"Dihydroorotate dehydrogenase (quinone), mitochondrial","SPAC57A10.12c",280,{"v":3e-81,"d":"3.00E-81"},"COG0167","pfam01180","DHO_dh","Dihydroorotate dehydrogenase.","GO:0006207|'de novo' pyrimidine nucleobase biosynthetic process;GO:0006225|UDP biosynthetic process;GO:0007565|female pregnancy;GO:0007595|lactation;GO:0009220|pyrimidine ribonucleotide biosynthetic process;GO:0009410|response to xenobiotic stimulus;GO:0014070|response to organic cyclic compound;GO:0031000|response to caffeine;GO:0042594|response to starvation;GO:0043065|positive regulation of apoptotic process;GO:0044205|'de novo' UMP biosynthetic process;GO:0090140|regulation of mitochondrial fission;GO:1903576|response to L-arginine;","GO:0005654|nucleoplasm;GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0005829|cytosol;GO:0016021|integral component of membrane;GO:0043025|neuronal cell body;","GO:0004151|dihydroorotase activity;GO:0004152|dihydroorotate dehydrogenase activity;GO:0010181|FMN binding;GO:0048038|quinone binding;GO:0048039|ubiquinone binding;","K00254","DHODH, pyrD; dihydroorotate dehydrogenase [EC:1.3.5.2]"]
["ENSRNOG00000008603",248,15.95394867,11,0.710180456,22.46464054,4.489584072,{"v":6.04127e-57,"d":"6.04E-57"},{"v":2.16053e-56,"d":"2.16E-56"},"up","yes","Gpr25","protein_coding","chr13:47713592-47714671:-","gi|293341342|ref|XP_001064036.2|",1349,0,"PREDICTED: probable G-protein coupled receptor 25 [Rattus norvegicus]","gi|672074193|ref|XM_008769579.1|",1080,0,"PREDICTED: Rattus norvegicus G protein-coupled receptor 25 (Gpr25), mRNA","P0C5I1",418,{"v":2e-143,"d":"2.00E-143"},"Probable G-protein coupled receptor 25",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;","K08405","GPR25; G protein-coupled receptor 25"]
["ENSRNOG00000016316",1182,76.03857793,531,34.28234748,2.218009662,1.14926565,{"v":1.2952e-56,"d":"1.30E-56"},{"v":4.59745e-56,"d":"4.60E-56"},"up","yes","Mcm2","protein_coding","chr4:121346434-121360847:-","gi|164607175|ref|NP_001101343.2|",4291,0,"DNA replication licensing factor MCM2 [Rattus norvegicus]","gi|164607174|ref|NM_001107873.2|",3261,0,"Rattus norvegicus minichromosome maintenance complex component 2 (Mcm2), mRNA","P97310",1642,0,"DNA replication licensing factor MCM2","SPBC4.04c",787,0,"COG1241","pfam00493","MCM","MCM2/3/5 family.","GO:0000727|double-strand break repair via break-induced replication;GO:0006268|DNA unwinding involved in DNA replication;GO:0006270|DNA replication initiation;GO:0006334|nucleosome assembly;GO:0006915|apoptotic process;GO:0071353|cellular response to interleukin-4;GO:0090102|cochlea development;GO:1902975|mitotic DNA replication initiation;GO:1905775|negative regulation of DNA helicase activity;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005664|nuclear origin of replication recognition complex;GO:0005737|cytoplasm;GO:0042555|MCM complex;","GO:0003674|molecular_function;GO:0003688|DNA replication origin binding;GO:0003697|single-stranded DNA binding;GO:0005524|ATP binding;GO:0017116|single-stranded DNA-dependent ATP-dependent DNA helicase activity;GO:0019899|enzyme binding;GO:0042393|histone binding;GO:0043138|3'-5' DNA helicase activity;GO:0046872|metal ion binding;","K02540","MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]"]
["ENSRNOG00000065394",294,18.91314883,28,1.80773207,10.46236283,3.387136803,{"v":2.52115e-56,"d":"2.52E-56"},{"v":8.91582e-56,"d":"8.92E-56"},"up","yes","ENSRNOG00000065394","lncRNA","chr1:31564-36478:+","gi|149066342|gb|EDM16215.1|",297,{"v":1E-26,"d":"1.00E-26"},"rCG59713 [Rattus norvegicus]","gi|14389324|gb|AC087775.2|",859,0,"Rattus norvegicus strain Brown Norway clone RP31-464J4, complete sequence","Q4VAE3",117,{"v":1E-27,"d":"1.00E-27"},"Transmembrane protein 65",".",".",".",".","pfam10507","DUF2453","Protein of unknown function (DUF2453). Some members of this family are purported to contain GAF domains but this could not be confirmed. The function is not known. It is likely to be a transmembrane protein.",".",".",".",".","."]
["ENSRNOG00000043445",1421,91.41355266,697,44.99961618,2.031429608,1.022495374,{"v":2.63794E-56,"d":"2.64E-56"},{"v":9.31733e-56,"d":"9.32E-56"},"up","yes","Them5","protein_coding","chr2:181980783-181986002:+","gi|157819023|ref|NP_001102028.1|",1261,{"v":2E-171,"d":"2.00E-171"},"acyl-coenzyme A thioesterase THEM5 [Rattus norvegicus]","gi|157819022|ref|NM_001108558.1|",1203,0,"Rattus norvegicus thioesterase superfamily member 5 (Them5), mRNA","Q9CQJ0",457,{"v":4E-160,"d":"4.00E-160"},"Acyl-coenzyme A thioesterase THEM5",".",".",".",".","pfam03061","4HBT","Thioesterase superfamily. This family contains a wide variety of enzymes, principally thioesterases. This family includes 4HBT (EC 3.1.2.23) which catalyses the final step in the biosynthesis of 4-hydroxybenzoate from 4-chlorobenzoate in the soil dwelling microbe Pseudomonas CBS-3. This family includes various cytosolic long-chain acyl-CoA thioester hydrolases. Long-chain acyl-CoA hydrolases hydrolyse palmitoyl-CoA to CoA and palmitate, they also catalyse the hydrolysis of other long chain fatty acyl-CoA thioesters.","GO:0035336|long-chain fatty-acyl-CoA metabolic process;GO:0035965|cardiolipin acyl-chain remodeling;","GO:0005759|mitochondrial matrix;","GO:0016290|palmitoyl-CoA hydrolase activity;","K22554","THEM5; acyl-coenzyme A thioesterase THEM5 [EC:3.1.2.2]"]
["ENSRNOG00000020063",933,60.02029883,370,23.88788807,2.512582889,1.329171191,{"v":3.56544e-56,"d":"3.57E-56"},{"v":1.25699e-55,"d":"1.26E-55"},"up","yes","Nfkbib","protein_coding","chr1:84046295-84053862:-","gi|55741426|ref|NP_110494.2|",1215,{"v":8e-161,"d":"8.00E-161"},"NF-kappa-B inhibitor beta [Rattus norvegicus]","gi|55741425|ref|NM_030867.2|",958,0,"Rattus norvegicus NFKB inhibitor beta (Nfkbib), mRNA","Q9JIA3",471,{"v":7e-162,"d":"7.00E-162"},"NF-kappa-B inhibitor beta",".",".",".",".","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0006954|inflammatory response;GO:0007165|signal transduction;GO:0007253|cytoplasmic sequestering of NF-kappaB;GO:0043122|regulation of I-kappaB kinase/NF-kappaB signaling;GO:0071222|cellular response to lipopolysaccharide;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0033256|I-kappaB/NF-kappaB complex;","GO:0051059|NF-kappaB binding;","K02581","NFKBIB; NF-kappa-B inhibitor beta"]
["ENSRNOG00000024809",960,61.75722066,388,25.05000155,2.465357958,1.301797134,{"v":5.59296e-56,"d":"5.59E-56"},{"v":1.96815e-55,"d":"1.97E-55"},"up","yes","Ntmt1","protein_coding","chr3:14093977-14110663:+","gi|564340256|ref|XP_006233981.1|",1485,0,"PREDICTED: N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform X2 [Rattus norvegicus]","gi|672044994|ref|XM_006233919.2|",2024,0,"PREDICTED: Rattus norvegicus N-terminal Xaa-Pro-Lys N-methyltransferase 1 (Ntmt1), transcript variant X1, mRNA","Q5BJX0",464,{"v":2e-158,"d":"2.00E-158"},"N-terminal Xaa-Pro-Lys N-methyltransferase 1",".",".",".",".","pfam05891","Methyltransf_PK","AdoMet dependent proline di-methyltransferase. This protein is expressed in the tail neuron PVT and in uterine cells in C. elegans [worm-base]. In Saccharomyces cerevisiae this is AdoMet dependent proline di-methyltransferase. This enzyme catalyses the di-methylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues. The methyltransferases described here specifically recognize the N-terminal X-Pro-Lys sequence motif, and they may account for nearly all previously described eukaryotic protein N-terminal methylation reactions. A number of other yeast and human proteins also share the recognition motif and may be similarly modified. As with other methyltransferases, this family carries the characteristic GxGxG motif.","GO:0006480|N-terminal protein amino acid methylation;GO:0007051|spindle organization;GO:0007059|chromosome segregation;GO:0016571|histone methylation;GO:0018011|N-terminal peptidyl-alanine methylation;GO:0018012|N-terminal peptidyl-alanine trimethylation;GO:0018013|N-terminal peptidyl-glycine methylation;GO:0018016|N-terminal peptidyl-proline dimethylation;GO:0035568|N-terminal peptidyl-proline methylation;GO:0035570|N-terminal peptidyl-serine methylation;GO:0035572|N-terminal peptidyl-serine dimethylation;GO:0035573|N-terminal peptidyl-serine trimethylation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0008168|methyltransferase activity;GO:0008276|protein methyltransferase activity;GO:0042054|histone methyltransferase activity;GO:0071885|N-terminal protein N-methyltransferase activity;","K16219","NTMT1, METTL11A, NTM1; protein N-terminal methyltransferase [EC:2.1.1.244]"]
["ENSRNOG00000026037",247,15.88961823,12,0.774742316,20.50955254,4.358224112,{"v":5.74838e-56,"d":"5.75E-56"},{"v":2.0216e-55,"d":"2.02E-55"},"up","yes","Plb1","protein_coding","chr6:24089214-24210117:-","gi|20302091|ref|NP_620253.1|",7624,0,"phospholipase B1, membrane-associated precursor [Rattus norvegicus]","gi|20302090|ref|NM_138898.1|",4584,0,"Rattus norvegicus phospholipase B1 (Plb1), mRNA","O54728",2944,0,"Phospholipase B1, membrane-associated",".",".",".",".","pfam00657","Lipase_GDSL","GDSL-like Lipase/Acylhydrolase.","GO:0006629|lipid metabolic process;GO:0006644|phospholipid metabolic process;GO:0019433|triglyceride catabolic process;GO:0034478|phosphatidylglycerol catabolic process;GO:0034638|phosphatidylcholine catabolic process;GO:0042572|retinol metabolic process;GO:0046338|phosphatidylethanolamine catabolic process;GO:0046340|diacylglycerol catabolic process;GO:2000344|positive regulation of acrosome reaction;","GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0031526|brush border membrane;","GO:0004620|phospholipase activity;GO:0004622|lysophospholipase activity;GO:0004623|phospholipase A2 activity;GO:0004806|triglyceride lipase activity;GO:0047499|calcium-independent phospholipase A2 activity;GO:0050253|retinyl-palmitate esterase activity;GO:0102545|phosphatidyl phospholipase B activity;","K14621","PLB1, PLB; phospholipase B1, membrane-associated [EC:3.1.1.4 3.1.1.5]"]
["ENSRNOG00000064680",980,63.04382942,403,26.01842944,2.423045156,1.276821291,{"v":1.81177E-55,"d":"1.81E-55"},{"v":6.30951E-55,"d":"6.31E-55"},"up","yes","Gpihbp1","protein_coding","chr7:107285654-107288702:+","gi|194474096|ref|NP_001124019.1|",1037,{"v":2e-133,"d":"2.00E-133"},"glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 precursor [Rattus norvegicus]","gi|194474095|ref|NM_001130547.1|",2080,0,"Rattus norvegicus glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 (Gpihbp1), mRNA","Q9D1N2",318,{"v":6E-102,"d":"6.00E-102"},"Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1",".",".",".",".","pfam15240","Pro-rich","Proline-rich. This family includes several eukaryotic proline-rich proteins.",".",".",".",".","."]
["ENSRNOG00000049351",352,22.64431424,53,3.421778562,6.617702996,2.726330545,{"v":5.58234e-55,"d":"5.58E-55"},{"v":1.93697E-54,"d":"1.94E-54"},"up","yes","Nat8l","protein_coding","chr14:76756077-76763411:-","gi|134288912|ref|NP_001001985.3|",1097,{"v":2e-135,"d":"2.00E-135"},"N-acetylaspartate synthetase [Mus musculus]","gi|300794295|ref|NM_001191681.1|",3279,0,"Rattus norvegicus N-acetyltransferase 8-like (Nat8l), mRNA","D3ZVU9",425,{"v":4E-136,"d":"4.00E-136"},"N-acetylaspartate synthetase","YPO3444",56.6,5e-08,"COG0454","pfam00583","Acetyltransf_1","Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.","GO:0051586|positive regulation of dopamine uptake involved in synaptic transmission;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0030867|rough endoplasmic reticulum membrane;GO:0031966|mitochondrial membrane;","GO:0008080|N-acetyltransferase activity;GO:0017188|aspartate N-acetyltransferase activity;","K18309","NAT8L; aspartate N-acetyltransferase [EC:2.3.1.17]"]
["ENSRNOG00000004542",826,53.13694194,308,19.88505277,2.672205226,1.418030811,{"v":6.28243e-55,"d":"6.28E-55"},{"v":2.1746E-54,"d":"2.17E-54"},"up","yes","Ttc8","protein_coding","chr6:118198201-118252418:+","gi|564356885|ref|XP_006240485.1|",2672,0,"PREDICTED: tetratricopeptide repeat protein 8 isoform X2 [Rattus norvegicus]","gi|672056504|ref|XM_006240423.2|",2313,0,"PREDICTED: Rattus norvegicus tetratricopeptide repeat domain 8 (Ttc8), transcript variant X2, mRNA","Q8VD72",1016,0,"Tetratricopeptide repeat protein 8",".",".",".",".","pfam13429","TPR_15","Tetratricopeptide repeat.","GO:0001736|establishment of planar polarity;GO:0007411|axon guidance;GO:0007608|sensory perception of smell;GO:0008150|biological_process;GO:0021772|olfactory bulb development;GO:0032880|regulation of protein localization;GO:0034260|negative regulation of GTPase activity;GO:0035264|multicellular organism growth;GO:0045198|establishment of epithelial cell apical/basal polarity;GO:0045444|fat cell differentiation;GO:0048560|establishment of anatomical structure orientation;GO:0051492|regulation of stress fiber assembly;GO:0060122|inner ear receptor cell stereocilium organization;GO:0060219|camera-type eye photoreceptor cell differentiation;GO:0060271|cilium assembly;GO:0061326|renal tubule development;GO:0072659|protein localization to plasma membrane;GO:1903251|multi-ciliated epithelial cell differentiation;GO:1905515|non-motile cilium assembly;","GO:0005575|cellular_component;GO:0005813|centrosome;GO:0005929|cilium;GO:0016020|membrane;GO:0032391|photoreceptor connecting cilium;GO:0034464|BBSome;GO:0036064|ciliary basal body;GO:0097730|non-motile cilium;","GO:0003674|molecular_function;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;","K16781","TTC8, BBS8; tetratricopeptide repeat protein 8"]
["ENSRNOG00000012021",1162,74.75196917,526,33.95953818,2.201206883,1.138294745,{"v":7.28001e-55,"d":"7.28E-55"},{"v":2.50926E-54,"d":"2.51E-54"},"up","yes","Ctnnbl1","protein_coding","chr3:146387889-146548987:+","gi|67846018|ref|NP_001020041.1|",2810,0,"beta-catenin-like protein 1 [Rattus norvegicus]","gi|67846017|ref|NM_001024870.1|",1812,0,"Rattus norvegicus catenin, beta like 1 (Ctnnbl1), mRNA","Q4V8K2",1083,0,"Beta-catenin-like protein 1",".",".",".",".","pfam08216","CTNNBL","Catenin-beta-like, Arm-motif containing nuclear. CTNNBL is a family of eukaryotic nuclear proteins of the catenin-beta-like 1 type that contain an armadillo motif. A human nuclear protein with this domain is thought to have a role in apoptosis. The interaction of CTNNBL1 with its known partners (the Prp19-CDC5L complex and AID) is mediated by recognition of NLS (nuclear localisation signal) motifs. The RNA-splicing factor Prp31 is also an interactor, with recognition also occurring through the NLS. CTNNBL1 uses its central armadillo (ARM) domain to bind NLS-containing partners.","GO:0006397|mRNA processing;GO:0006915|apoptotic process;GO:0008150|biological_process;GO:0008380|RNA splicing;GO:0016445|somatic diversification of immunoglobulins;GO:0043065|positive regulation of apoptotic process;","GO:0000974|Prp19 complex;GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005681|spliceosomal complex;GO:0005813|centrosome;GO:0005829|cytosol;","GO:0003674|molecular_function;GO:0019899|enzyme binding;","K12864","CTNNBL1; beta-catenin-like protein 1"]
["ENSRNOG00000027730",420,27.01878404,84,5.423196211,4.98207754,2.316747476,{"v":1.31258E-54,"d":"1.31E-54"},{"v":4.51327E-54,"d":"4.51E-54"},"up","yes","Nxpe1","protein_coding","chr8:48751014-48785353:+","gi|564363589|ref|XP_006243080.1|",2997,0,"PREDICTED: NXPE family member 1 isoform X1 [Rattus norvegicus]","gi|672061782|ref|XM_006243018.2|",2597,0,"PREDICTED: Rattus norvegicus similar to protein of unknown function (RGD1566243), transcript variant X1, mRNA","Q8N323",755,0,"NXPE family member 1",".",".",".",".","pfam06312","Neurexophilin","Neurexophilin. This family consists of mammalian neurexophilin proteins. Mammalian brains contain four different neurexophilin proteins. Neurexophilins form a family of related glycoproteins that are proteolytically processed after synthesis and bind to alpha-neurexins. The structure and characteristics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins.",".",".",".",".","."]
["ENSRNOG00000069743",389,25.02454045,71,4.583892036,5.459234262,2.448698606,{"v":5.34964E-54,"d":"5.35E-54"},{"v":1.82409e-53,"d":"1.82E-53"},"up","yes","Nxpe5l1","protein_coding","chr12:17186134-17196403:+","gi|672072443|ref|XP_008767296.1|",2942,0,"PREDICTED: NXPE family member 3-like isoform X2 [Rattus norvegicus]","gi|672072442|ref|XM_008769074.1|",1656,0,"PREDICTED: Rattus norvegicus neurexophilin and PC-esterase domain family, member 5 (Nxpe5), transcript variant X2, mRNA","A2VDP6",328,{"v":7e-103,"d":"7.00E-103"},"NXPE family member 3",".",".",".",".","pfam06312","Neurexophilin","Neurexophilin. This family consists of mammalian neurexophilin proteins. Mammalian brains contain four different neurexophilin proteins. Neurexophilins form a family of related glycoproteins that are proteolytically processed after synthesis and bind to alpha-neurexins. The structure and characteristics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins.",".",".",".",".","."]
["ENSRNOG00000065430",1186,76.29589969,550,35.50902281,2.148634168,1.103419867,{"v":2.60042e-53,"d":"2.60E-53"},{"v":8.82461e-53,"d":"8.82E-53"},"up","yes","Zfp958","protein_coding","chr12:3953455-3975514:+","gi|218505767|ref|NP_001136230.1|",2257,0,"zinc finger protein 878 [Rattus norvegicus]","gi|218505766|ref|NM_001142758.1|",1511,0,"Rattus norvegicus zinc finger protein 958 (Zfp958), mRNA","E9QAG8",579,0,"Zinc finger protein 431",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000028113",914,58.7980205,370,23.88788807,2.461415606,1.299488275,{"v":3.05722e-53,"d":"3.06E-53"},{"v":1.03624E-52,"d":"1.04E-52"},"up","yes","Whamm","protein_coding","chr1:135526386-135554759:+","gi|195539466|ref|NP_001124200.1|",3743,0,"WASP homolog-associated protein with actin, membranes and microtubules [Rattus norvegicus]","gi|195539465|ref|NM_001130728.1|",2849,0,"Rattus norvegicus WAS protein homolog associated with actin, golgi membranes and microtubules (Whamm), mRNA","Q571B6",1227,0,"WASP homolog-associated protein with actin, membranes and microtubules",".",".",".",".","pfam12128","DUF3584","Protein of unknown function (DUF3584). This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.","GO:0006888|ER to Golgi vesicle-mediated transport;GO:0007015|actin filament organization;GO:0030032|lamellipodium assembly;GO:0034314|Arp2/3 complex-mediated actin nucleation;GO:0048041|focal adhesion assembly;GO:0051127|positive regulation of actin nucleation;GO:0090527|actin filament reorganization;GO:0097320|plasma membrane tubulation;","GO:0000139|Golgi membrane;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0033116|endoplasmic reticulum-Golgi intermediate compartment membrane;","GO:0003779|actin binding;GO:0008017|microtubule binding;GO:0031267|small GTPase binding;GO:0071933|Arp2/3 complex binding;","K20479","WHAMM; WASP homolog-associated protein with actin, membranes and microtubules"]
["ENSRNOG00000010078",590,37.95495853,178,11.49201102,3.30272556,1.723657094,{"v":3.10937e-52,"d":"3.11E-52"},{"v":1.04339e-51,"d":"1.04E-51"},"up","yes","Spag1","protein_coding","chr7:67361477-67421368:+","gi|58865802|ref|NP_001012116.1|",4448,0,"sperm-associated antigen 1 [Rattus norvegicus]","gi|58865801|ref|NM_001012116.1|",3650,0,"Rattus norvegicus sperm associated antigen 1 (Spag1), mRNA","Q5U2X2",1717,0,"Sperm-associated antigen 1",".",".",".",".","pfam13877","RPAP3_C","Potential Monad-binding region of RPAP3. This domain is found at the C-terminus of RNA-polymerase II-associated proteins. These proteins bind to Monad and are involved in regulating apoptosis.   They contain TPR-repeats towards the N_terminus.","GO:0007338|single fertilization;GO:0070286|axonemal dynein complex assembly;","GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0005525|GTP binding;GO:0016787|hydrolase activity;","K19870","SPAG1; sperm-associated antigen 1"]
["ENSRNOG00000012436",846,54.4235507,331,21.36997555,2.546729667,1.348645827,{"v":3.22539e-52,"d":"3.23E-52"},{"v":1.08106E-51,"d":"1.08E-51"},"up","yes","Adh6","protein_coding","chr2:226797303-226808892:+","gi|21070353|gb|AAM34269.1|AF508795_1",1809,0,"ADH-like protein [Rattus norvegicus]","gi|685156909|ref|NM_019286.4|",1806,0,"Rattus norvegicus alcohol dehydrogenase 1 (class I) (Adh1), mRNA","P06757",701,0,"Alcohol dehydrogenase 1","YPO1502",366,{"v":5e-120,"d":"5.00E-120"},"COG1062","pfam08240","ADH_N","Alcohol dehydrogenase GroES-like domain. This is the catalytic domain of alcohol dehydrogenases. Many of them contain an inserted zinc binding domain. This domain has a GroES-like structure.","GO:0001523|retinoid metabolic process;GO:0006068|ethanol catabolic process;GO:0006069|ethanol oxidation;GO:0008150|biological_process;GO:0031100|animal organ regeneration;GO:0032526|response to retinoic acid;GO:0032570|response to progesterone;GO:0033574|response to testosterone;GO:0042572|retinol metabolic process;GO:0042573|retinoic acid metabolic process;GO:0046186|acetaldehyde biosynthetic process;GO:0048149|behavioral response to ethanol;GO:0048545|response to steroid hormone;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0003674|molecular_function;GO:0004022|alcohol dehydrogenase (NAD) activity;GO:0004024|alcohol dehydrogenase activity, zinc-dependent;GO:0004745|retinol dehydrogenase activity;GO:0008270|zinc ion binding;GO:0016491|oxidoreductase activity;GO:0035276|ethanol binding;GO:0042802|identical protein binding;GO:0051287|NAD binding;GO:0097159|organic cyclic compound binding;","K13951","ADH1_7; alcohol dehydrogenase 1/7 [EC:1.1.1.1]K13951; K13952"]
["ENSRNOG00000024975",358,23.03029687,61,3.938273439,5.847815604,2.54789782,{"v":4.73096e-52,"d":"4.73E-52"},{"v":1.57919e-51,"d":"1.58E-51"},"up","yes","Atp8b3","protein_coding","chr7:9175391-9195442:+","gi|109480229|ref|XP_234937.3|",6879,0,"PREDICTED: phospholipid-transporting ATPase IK [Rattus norvegicus]","gi|672021396|ref|XM_001076355.5|",3848,0,"PREDICTED: Rattus norvegicus ATPase, aminophospholipid transporter, class I, type 8B, member 3 (Atp8b3), mRNA","Q6UQ17",2310,0,"Phospholipid-transporting ATPase IK",".",".",".",".","pfam13246","Hydrolase_like2","Putative hydrolase of sodium-potassium ATPase alpha subunit. This is a putative hydrolase of the sodium-potassium ATPase alpha subunit.","GO:0007030|Golgi organization;GO:0007339|binding of sperm to zona pellucida;GO:0045332|phospholipid translocation;","GO:0001669|acrosomal vesicle;GO:0005802|trans-Golgi network;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0000287|magnesium ion binding;GO:0005524|ATP binding;","K01530","E7.6.2.1; phospholipid-translocating ATPase [EC:7.6.2.1]"]
["ENSRNOG00000020925",976,62.78650767,417,26.92229548,2.332137976,1.221653145,{"v":1.12648E-51,"d":"1.13E-51"},{"v":3.73833e-51,"d":"3.74E-51"},"up","yes","Ccdc86","protein_coding","chr1:207590168-207596544:-","gi|55741516|ref|NP_001006975.1|",1372,0,"coiled-coil domain-containing protein 86 [Rattus norvegicus]","gi|54035522|gb|BC083770.1|",1405,0,"Rattus norvegicus coiled-coil domain containing 86, mRNA (cDNA clone MGC:94720 IMAGE:7193350), complete cds","Q5XIB5",533,0,"Coiled-coil domain-containing protein 86",".",".",".",".","pfam11489","DUF3210","Protein of unknown function (DUF3210). This is a family of proteins conserved in yeasts. The function is not known. The Schizosaccharomyces pombe member is SPBC18E5.07 and the Saccharomyces cerevisiae member is AIM21.",".","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005694|chromosome;GO:0005730|nucleolus;",".","K14822","CGR1; rRNA-processing protein CGR1"]
["ENSRNOG00000005266",210,13.50939202,4,0.258247439,52.31181417,5.709064898,{"v":2.78524e-51,"d":"2.79E-51"},{"v":9.20566e-51,"d":"9.21E-51"},"up","yes","Amdhd1","protein_coding","chr7:28043716-28059156:-","gi|300796311|ref|NP_001178710.1|",2143,0,"probable imidazolonepropionase [Rattus norvegicus]","gi|300796310|ref|NM_001191781.1|",1290,0,"Rattus norvegicus amidohydrolase domain containing 1 (Amdhd1), mRNA","Q9DBA8",776,0,"Probable imidazolonepropionase","FN0740",234,{"v":5e-70,"d":"5.00E-70"},"COG1228","pfam13147","Amidohydro_4","Amidohydrolase. This family of enzymes are a part of a large metal dependent hydrolase superfamily. The family includes Adenine deaminase EC:3.5.4.2 that hydrolyses adenine to form hypoxanthine and ammonia. Adenine deaminases reaction is important for adenine utilisation as a purine and also as a nitrogen source. This family also includes dihydroorotase and N-acetylglucosamine-6-phosphate deacetylases, EC:3.5.1.25 These enzymes catalyse the reaction N-acetyl-D-glucosamine 6-phosphate + H2O <=> D-glucosamine 6-phosphate + acetate. This family includes the catalytic domain of urease alpha subunit. Dihydroorotases (EC:3.5.2.3) are also included.","GO:0006548|histidine catabolic process;GO:0019556|histidine catabolic process to glutamate and formamide;GO:0019557|histidine catabolic process to glutamate and formate;","GO:0005737|cytoplasm;","GO:0050480|imidazolonepropionase activity;","K01468","hutI, AMDHD1; imidazolonepropionase [EC:3.5.2.7]"]
["ENSRNOG00000014598",1115,71.72843858,514,33.18479586,2.161485003,1.112022826,{"v":7.72055e-51,"d":"7.72E-51"},{"v":2.53125e-50,"d":"2.53E-50"},"up","yes","Abhd13","protein_coding","chr16:79501727-79516748:-","gi|402695408|ref|NP_001258001.1|",1644,0,"alpha/beta hydrolase domain-containing protein 13 [Rattus norvegicus]","gi|402695407|ref|NM_001271072.1|",5000,0,"Rattus norvegicus abhydrolase domain containing 13 (Abhd13), mRNA","Q80UX8",635,0,"Protein ABHD13","SPBC32H8.03",195,{"v":2e-53,"d":"2.00E-53"},"COG1073","pfam12695","Abhydrolase_5","Alpha/beta hydrolase family. This family contains a diverse range of alpha/beta hydrolase enzymes.","GO:0002084|protein depalmitoylation;","GO:0005737|cytoplasm;GO:0016020|membrane;GO:0032839|dendrite cytoplasm;","GO:0008474|palmitoyl-(protein) hydrolase activity;","K24083","ABHD13; abhydrolase domain-containing protein 13 [EC:3.-.-.-]"]
["ENSRNOG00000047635",258,16.59725305,23,1.484922772,11.17718265,3.48248468,{"v":9.78781e-51,"d":"9.79E-51"},{"v":3.20351e-50,"d":"3.20E-50"},"up","yes","Tmem178b","protein_coding","chr4:68657343-69035690:+","gi|305632805|ref|NP_001182206.1|",1572,0,"transmembrane protein 178B precursor [Rattus norvegicus]","gi|305632804|ref|NM_001195277.1|",10111,0,"Rattus norvegicus transmembrane protein 178B (Tmem178b), mRNA","H3BS89",606,0,"Transmembrane protein 178B",".",".",".",".","pfam13903","Claudin_2","PMP-22/EMP/MP20/Claudin tight junction. Members of this family are claudins, that form tight junctions between cells.",".","GO:0016020|membrane;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000032048",902,58.02605524,374,24.14613551,2.403119755,1.264908544,{"v":1.76636E-50,"d":"1.77E-50"},{"v":5.73521e-50,"d":"5.74E-50"},"up","yes","Zfp462","protein_coding","chr5:69670328-69810327:+","gi|672052667|ref|XP_008761951.1|",12273,0,"PREDICTED: zinc finger protein 462 isoform X4 [Rattus norvegicus]","gi|672052666|ref|XM_008763729.1|",9819,0,"PREDICTED: Rattus norvegicus zinc finger protein 462 (Zfp462), transcript variant X6, mRNA","Q96JM2",3569,0,"Zinc finger protein 462",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0006325|chromatin organization;GO:0010468|regulation of gene expression;GO:0043392|negative regulation of DNA binding;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;",".","K24853","ZNF462; zinc finger protein 462"]
["ENSRNOG00000005602",1129,72.62906471,527,34.02410004,2.13463588,1.09399,{"v":3.69954E-50,"d":"3.70E-50"},{"v":1.1978E-49,"d":"1.20E-49"},"up","yes","Mthfd1","protein_coding","chr6:94977862-95045372:+","gi|149051483|gb|EDM03656.1|",4724,0,"methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase, isoform CRA_b [Rattus norvegicus]","gi|11968081|ref|NM_022508.1|",3317,0,"Rattus norvegicus methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase (Mthfd1), mRNA","P27653",1822,0,"C-1-tetrahydrofolate synthase, cytoplasmic","YGR204w_2",717,0,"COG2759","pfam01268","FTHFS","Formate--tetrahydrofolate ligase.","GO:0000105|histidine biosynthetic process;GO:0001780|neutrophil homeostasis;GO:0001843|neural tube closure;GO:0006164|purine nucleotide biosynthetic process;GO:0006555|methionine metabolic process;GO:0006730|one-carbon metabolic process;GO:0007507|heart development;GO:0009069|serine family amino acid metabolic process;GO:0009070|serine family amino acid biosynthetic process;GO:0009086|methionine biosynthetic process;GO:0009117|nucleotide metabolic process;GO:0009257|10-formyltetrahydrofolate biosynthetic process;GO:0019346|transsulfuration;GO:0035713|response to nitrogen dioxide;GO:0035999|tetrahydrofolate interconversion;GO:0046653|tetrahydrofolate metabolic process;GO:0061053|somite development;","GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004329|formate-tetrahydrofolate ligase activity;GO:0004477|methenyltetrahydrofolate cyclohydrolase activity;GO:0004486|methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity;GO:0004487|methylenetetrahydrofolate dehydrogenase (NAD+) activity;GO:0004488|methylenetetrahydrofolate dehydrogenase (NADP+) activity;GO:0005524|ATP binding;","K00288","MTHFD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3]"]
["ENSRNOG00000026036",227,14.60300947,13,0.839304176,17.39894772,4.12092815,{"v":4.02034E-50,"d":"4.02E-50"},{"v":1.30019e-49,"d":"1.30E-49"},"up","yes","Pdyn","protein_coding","chr3:116900992-116913334:-","gi|186700610|ref|NP_062247.2|",1191,{"v":6e-155,"d":"6.00E-155"},"proenkephalin-B preproprotein [Rattus norvegicus]","gi|186700609|ref|NM_019374.3|",2439,0,"Rattus norvegicus prodynorphin (Pdyn), mRNA","P06300",460,{"v":3e-155,"d":"3.00E-155"},"Proenkephalin-B",".",".",".",".","pfam01160","Opiods_neuropep","Vertebrate endogenous opioids neuropeptide.","GO:0007218|neuropeptide signaling pathway;GO:0007268|chemical synaptic transmission;GO:0007600|sensory perception;GO:0046928|regulation of neurotransmitter secretion;","GO:0005576|extracellular region;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0008021|synaptic vesicle;GO:0030425|dendrite;GO:0043025|neuronal cell body;GO:0043679|axon terminus;GO:0045202|synapse;GO:0099013|neuronal dense core vesicle lumen;","GO:0001515|opioid peptide activity;GO:0005515|protein binding;GO:0031628|opioid receptor binding;","K15840","PDYN, PENKB; proenkephalin B (prodynorphin)"]
["ENSRNOG00000048114",421,27.08311448,95,6.133376667,4.415693988,2.142640195,{"v":6.8239e-50,"d":"6.82E-50"},{"v":2.1994E-49,"d":"2.20E-49"},"up","yes","Echdc3","protein_coding","chr17:72070668-72093516:+","gi|155369702|ref|NP_001094480.1|",1570,0,"enoyl-CoA hydratase domain-containing protein 3, mitochondrial precursor [Rattus norvegicus]","gi|298911413|emb|FQ219501.1|",1471,0,"Rattus norvegicus TL0ABA44YN06 mRNA sequence","Q3MIE0",609,0,"Enoyl-CoA hydratase domain-containing protein 3, mitochondrial",".",".",".",".","pfam00378","ECH","Enoyl-CoA hydratase/isomerase family. This family contains a diverse set of enzymes including: Enoyl-CoA hydratase. Napthoate synthase. Carnitate racemase. 3-hydoxybutyryl-CoA dehydratase. Dodecanoyl-CoA delta-isomerase.","GO:0006631|fatty acid metabolic process;GO:1900078|positive regulation of cellular response to insulin stimulus;","GO:0005739|mitochondrion;","GO:0003824|catalytic activity;GO:0004300|enoyl-CoA hydratase activity;GO:0016836|hydro-lyase activity;",".","."]
["ENSRNOG00000063040",630,40.52817606,209,13.49342867,3.003549139,1.586668267,{"v":1.18862E-49,"d":"1.19E-49"},{"v":3.82025e-49,"d":"3.82E-49"},"up","yes","ENSRNOG00000063040","protein_coding","chr9:114137793-114149279:+","gi|564349900|ref|XP_006237777.1|",738,{"v":2e-142,"d":"2.00E-142"},"PREDICTED: zinc finger protein 431-like isoform X3 [Rattus norvegicus]","gi|672051756|ref|XR_353790.2|",713,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102550336 (LOC102550336), ncRNA","E9QAG8",303,{"v":1E-108,"d":"1.00E-108"},"Zinc finger protein 431",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000024578",1217,78.29014327,591,38.15605906,2.051840395,1.036918513,{"v":1.44631E-49,"d":"1.45E-49"},{"v":4.63022e-49,"d":"4.63E-49"},"up","yes","Ttyh2","protein_coding","chr10:99709007-99753444:+","gi|564375166|ref|XP_221081.7|",2521,0,"PREDICTED: protein tweety homolog 2 isoform X2 [Rattus norvegicus]","gi|672025416|ref|XM_006220891.2|",3098,0,"PREDICTED: Rattus norvegicus tweety family member 2 (Ttyh2), transcript variant X1, mRNA","Q3TH73",877,0,"Protein tweety homolog 2",".",".",".",".","pfam04906","Tweety","Tweety. The tweety (tty) gene has not been characterized at the protein level. However, it is thought to form a membrane protein with five potential membrane-spanning regions. A number of potential functions have been suggested in.","GO:0006821|chloride transport;","GO:0005886|plasma membrane;GO:0034707|chloride channel complex;","GO:0005229|intracellular calcium activated chloride channel activity;GO:0072320|volume-sensitive chloride channel activity;","K22641","TTYH; protein tweety"]
["ENSRNOG00000056889",911,58.60502919,385,24.85631597,2.35775202,1.237411989,{"v":2.66374E-49,"d":"2.66E-49"},{"v":8.48491e-49,"d":"8.48E-49"},"up","yes","Vps33a","protein_coding","chr12:33024650-33051393:+","gi|155369738|ref|NP_075250.2|",3011,0,"vacuolar protein sorting-associated protein 33A [Rattus norvegicus]","gi|1477467|gb|U35244.1|RNU35244",3136,0,"Rat vacuolar protein sorting homolog r-vps33a mRNA, complete cds","Q63615",1149,0,"Vacuolar protein sorting-associated protein 33A","SPBC1703.15c",269,{"v":3e-77,"d":"3.00E-77"},"COG5158","pfam00995","Sec1","Sec1 family.","GO:0006886|intracellular protein transport;GO:0008150|biological_process;GO:0008333|endosome to lysosome transport;GO:0015031|protein transport;GO:0016192|vesicle-mediated transport;GO:0030220|platelet formation;GO:0032400|melanosome localization;GO:0032418|lysosome localization;GO:0035751|regulation of lysosomal lumen pH;GO:0043473|pigmentation;GO:0048070|regulation of developmental pigmentation;GO:0097352|autophagosome maturation;","GO:0005764|lysosome;GO:0005765|lysosomal membrane;GO:0005769|early endosome;GO:0005770|late endosome;GO:0005773|vacuole;GO:0005776|autophagosome;GO:0030136|clathrin-coated vesicle;GO:0030897|HOPS complex;GO:0031410|cytoplasmic vesicle;GO:0031902|late endosome membrane;GO:0033263|CORVET complex;GO:0048471|perinuclear region of cytoplasm;","GO:0005515|protein binding;GO:0044877|protein-containing complex binding;","K20182","VPS33A; vacuolar protein sorting-associated protein 33A"]
["ENSRNOG00000046566",280,18.01252269,34,2.195103228,8.205774772,3.036639556,{"v":6.29526e-49,"d":"6.30E-49"},{"v":1.99856E-48,"d":"2.00E-48"},"up","yes","Tub","protein_coding","chr1:162951931-163026812:+","gi|795247956|ref|XP_011809763.1|",2058,0,"PREDICTED: tubby protein homolog isoform X1 [Colobus angolensis palliatus]","gi|672037725|ref|XM_008759690.1|",1536,0,"PREDICTED: Rattus norvegicus tubby bipartite transcription factor (Tub), transcript variant X1, mRNA","P50607",747,0,"Tubby protein homolog",".",".",".",".","pfam01167","Tub","Tub family.","GO:0006910|phagocytosis, recognition;GO:0007605|sensory perception of sound;GO:0008277|regulation of G protein-coupled receptor signaling pathway;GO:0009725|response to hormone;GO:0042073|intraciliary transport;GO:0045494|photoreceptor cell maintenance;GO:0050766|positive regulation of phagocytosis;GO:0060041|retina development in camera-type eye;GO:0061512|protein localization to cilium;GO:0097500|receptor localization to non-motile cilium;GO:1903546|protein localization to photoreceptor outer segment;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005929|cilium;","GO:0001664|G protein-coupled receptor binding;GO:0003674|molecular_function;GO:0044877|protein-containing complex binding;GO:0120160|intraciliary transport particle A binding;","K19600","TUB, TULP; tubby and related proteins"]
["ENSRNOG00000012568",1172,75.39527355,564,36.41288885,2.070565559,1.050024883,{"v":9.34317e-49,"d":"9.34E-49"},{"v":2.94816e-48,"d":"2.95E-48"},"up","yes","Madd","protein_coding","chr3:77114314-77157701:-","gi|148695595|gb|EDL27542.1|",7520,0,"MAP-kinase activating death domain, isoform CRA_k, partial [Mus musculus]","gi|295148168|ref|NM_001177719.1|",4175,0,"Mus musculus MAP-kinase activating death domain (Madd), transcript variant 10, mRNA","Q80U28",2891,0,"MAP kinase-activating death domain protein",".",".",".",".","pfam02141","DENN","DENN (AEX-3) domain. DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.","GO:0032483|regulation of Rab protein signal transduction;GO:0042981|regulation of apoptotic process;GO:0043410|positive regulation of MAPK cascade;GO:0048490|anterograde synaptic vesicle transport;GO:0050790|regulation of catalytic activity;GO:0051726|regulation of cell cycle;GO:0060125|negative regulation of growth hormone secretion;GO:0097194|execution phase of apoptosis;GO:1902041|regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1902277|negative regulation of pancreatic amylase secretion;GO:2001234|negative regulation of apoptotic signaling pathway;GO:2001236|regulation of extrinsic apoptotic signaling pathway;","GO:0005634|nucleus;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0008021|synaptic vesicle;GO:0016021|integral component of membrane;GO:0045202|synapse;GO:1904115|axon cytoplasm;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0005515|protein binding;",".","."]
["ENSRNOG00000062679",493,31.71490603,135,8.715851053,3.638761818,1.86344762,{"v":1.00511e-48,"d":"1.01E-48"},{"v":3.16806E-48,"d":"3.17E-48"},"up","yes","Akr1c13","protein_coding","chr17:65964975-65997591:+","gi|564392048|ref|XP_006254252.1|",1995,0,"PREDICTED: aldo-keto reductase family 1, member C12 isoform X3 [Rattus norvegicus]","gi|672082446|ref|XM_006254190.2|",1406,0,"PREDICTED: Rattus norvegicus aldo-keto reductase family 1, member C12 (Akr1c12), transcript variant X2, mRNA","Q8VC28",573,0,"Aldo-keto reductase family 1 member C13","YOR120w",186,{"v":3e-53,"d":"3.00E-53"},"COG0656","pfam00248","Aldo_ket_red","Aldo/keto reductase family. This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.",".",".",".",".","."]
["ENSRNOG00000067300",1184,76.16723881,573,36.99394558,2.058910927,1.041881418,{"v":1.2322e-48,"d":"1.23E-48"},{"v":3.87953e-48,"d":"3.88E-48"},"up","yes","Crebl2","protein_coding","chr4:167673315-167699292:+","gi|62543539|ref|NP_001015027.1|",530,{"v":7e-59,"d":"7.00E-59"},"cAMP-responsive element-binding protein-like 2 [Rattus norvegicus]","gi|62543538|ref|NM_001015027.1|",3318,0,"Rattus norvegicus cAMP responsive element binding protein-like 2 (Crebl2), mRNA","Q5BJU6",208,{"v":2e-60,"d":"2.00E-60"},"cAMP-responsive element-binding protein-like 2",".",".",".",".","pfam07716","bZIP_2","Basic region leucine zipper.",".",".",".",".","."]
["ENSRNOG00000024986",596,38.34094116,193,12.46043891,3.077013693,1.621530864,{"v":1.63951E-48,"d":"1.64E-48"},{"v":5.15341e-48,"d":"5.15E-48"},"up","yes","Mmrn1","protein_coding","chr4:89903174-89950474:+","gi|293346833|ref|XP_001065496.2|",6350,0,"PREDICTED: multimerin-1 isoform X1 [Rattus norvegicus]","gi|672049873|ref|XM_001071128.5|",4299,0,"PREDICTED: Rattus norvegicus multimerin 1 (Mmrn1), transcript variant X1, mRNA","B2RPV6",2138,0,"Multimerin-1",".",".",".",".","pfam00386","C1q","C1q domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.","GO:0007596|blood coagulation;","GO:0005576|extracellular region;","GO:0005509|calcium ion binding;","K24247","MMRN; multimerin"]
["ENSRNOG00000013123",264,16.98323568,29,1.87229393,9.070817038,3.181232505,{"v":3.49664e-48,"d":"3.50E-48"},{"v":1.09009e-47,"d":"1.09E-47"},"up","yes","Scube2","protein_coding","chr1:163832015-163899393:-","gi|392337862|ref|XP_003753378.1|",5085,0,"PREDICTED: signal peptide, CUB and EGF-like domain-containing protein 2 isoform X1 [Rattus norvegicus]","gi|672014129|ref|XM_003753330.3|",3506,0,"PREDICTED: Rattus norvegicus signal peptide, CUB domain, EGF-like 2 (Scube2), transcript variant X1, mRNA","Q9JJS0",1737,0,"Signal peptide, CUB and EGF-like domain-containing protein 2",".",".",".",".","pfam00431","CUB","CUB domain.","GO:0003413|chondrocyte differentiation involved in endochondral bone morphogenesis;GO:0007165|signal transduction;GO:0045669|positive regulation of osteoblast differentiation;GO:0045778|positive regulation of ossification;GO:0045880|positive regulation of smoothened signaling pathway;GO:1902732|positive regulation of chondrocyte proliferation;","GO:0005615|extracellular space;GO:0009986|cell surface;","GO:0005509|calcium ion binding;GO:0097108|hedgehog family protein binding;","K24706","SCUBE2; signal peptide, CUB and EGF-like domain-containing protein 2"]
["ENSRNOG00000019584",261,16.79024437,28,1.80773207,9.288015985,3.215370455,{"v":4.2886e-48,"d":"4.29E-48"},{"v":1.33625E-47,"d":"1.34E-47"},"up","yes","Dlk1","protein_coding","chr6:128410316-128417522:+","gi|16758572|ref|NP_446196.1|",1896,0,"protein delta homolog 1 precursor [Rattus norvegicus]","gi|189442750|gb|BC167752.1|",1562,0,"Rattus norvegicus delta-like 1 homolog (Drosophila), mRNA (cDNA clone MGC:187346 IMAGE:8365650), complete cds","Q09163",696,0,"Protein delta homolog 1",".",".",".",".","pfam00008","EGF","EGF-like domain. There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.","GO:0001503|ossification;GO:0001649|osteoblast differentiation;GO:0001819|positive regulation of cytokine production;GO:0009791|post-embryonic development;GO:0010468|regulation of gene expression;GO:0030154|cell differentiation;GO:0030282|bone mineralization;GO:0035264|multicellular organism growth;GO:0045599|negative regulation of fat cell differentiation;GO:0045746|negative regulation of Notch signaling pathway;GO:0045780|positive regulation of bone resorption;GO:0048706|embryonic skeletal system development;GO:1905563|negative regulation of vascular endothelial cell proliferation;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0009897|external side of plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;GO:0005515|protein binding;","K24461","DLK1; protein delta homolog 1"]
["ENSRNOG00000057989",404,25.98949703,91,5.875129229,4.423646871,2.145236223,{"v":5.08819e-48,"d":"5.09E-48"},{"v":1.58453e-47,"d":"1.58E-47"},"up","yes","Zp2","protein_coding","chr1:174513511-174525288:-","gi|149068078|gb|EDM17630.1|",3599,0,"zona pellucida glycoprotein 2, isoform CRA_b [Rattus norvegicus]","gi|13592142|ref|NM_031150.1|",2129,0,"Rattus norvegicus zona pellucida glycoprotein 2 (sperm receptor) (Zp2), mRNA","O54767",1388,0,"Zona pellucida sperm-binding protein 2",".",".",".",".","pfam00100","Zona_pellucida","Zona pellucida-like domain.","GO:0002455|humoral immune response mediated by circulating immunoglobulin;GO:0007339|binding of sperm to zona pellucida;GO:0060468|prevention of polyspermy;","GO:0005576|extracellular region;GO:0005771|multivesicular body;GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0016234|inclusion body;GO:0035805|egg coat;GO:0062023|collagen-containing extracellular matrix;","GO:0032190|acrosin binding;GO:0035804|structural constituent of egg coat;GO:0042802|identical protein binding;","K19927","ZP2; zona pellucida sperm-binding protein 2"]
["ENSRNOG00000013498",1166,75.00929092,564,36.41288885,2.059965394,1.042620101,{"v":5.61676e-48,"d":"5.62E-48"},{"v":1.74723E-47,"d":"1.75E-47"},"up","yes","Pex14","protein_coding","chr5:159399776-159536272:-","gi|81884113|sp|Q642G4.1|PEX14_RAT",1164,{"v":2E-150,"d":"2.00E-150"},"RecName: Full=Peroxisomal membrane protein PEX14; AltName: Full=PTS1 receptor-docking protein; AltName: Full=Peroxin-14; AltName: Full=Peroxisomal membrane anchor protein PEX14","gi|51980626|gb|BC081708.1|",1806,0,"Rattus norvegicus peroxisomal biogenesis factor 14, mRNA (cDNA clone MGC:93110 IMAGE:7191447), complete cds","Q642G4",452,{"v":7e-152,"d":"7.00E-152"},"Peroxisomal membrane protein PEX14",".",".",".",".","pfam04695","Pex14_N","Peroxisomal membrane anchor protein (Pex14p) conserved region. Family of peroxisomal membrane anchor proteins which bind the PTS1 (peroxisomal targeting signal) receptor and are required for the import of PTS1-containing proteins into peroxisomes. Loss of functional Pex14p results in defects in both the PTS1 and PTS2-dependent import pathways. Deletion analysis of this conserved region implicates it in selective peroxisome degradation. In the majority of members this region is situated at the N-terminus of the protein.","GO:0007031|peroxisome organization;GO:0016558|protein import into peroxisome matrix;GO:0016560|protein import into peroxisome matrix, docking;GO:0016561|protein import into peroxisome matrix, translocation;GO:0032091|negative regulation of protein binding;GO:0034453|microtubule anchoring;GO:0036250|peroxisome transport along microtubule;GO:0043433|negative regulation of DNA-binding transcription factor activity;GO:0044721|protein import into peroxisome matrix, substrate release;GO:0045892|negative regulation of transcription, DNA-templated;GO:0065003|protein-containing complex assembly;","GO:0001650|fibrillar center;GO:0005777|peroxisome;GO:0005778|peroxisomal membrane;GO:0016021|integral component of membrane;GO:0032991|protein-containing complex;GO:1990429|peroxisomal importomer complex;","GO:0003714|transcription corepressor activity;GO:0005102|signaling receptor binding;GO:0008017|microtubule binding;GO:0042802|identical protein binding;GO:0047485|protein N-terminus binding;GO:0048487|beta-tubulin binding;","K13343","PEX14; peroxin-14"]
["ENSRNOG00000065120",312,20.07109671,49,3.163531123,6.344523235,2.665511755,{"v":8.15274e-48,"d":"8.15E-48"},{"v":2.53059e-47,"d":"2.53E-47"},"up","yes","ENSRNOG00000065120","protein_coding","chr18:1588008-1590314:+","gi|183396771|ref|NP_034607.3|",2801,0,"60 kDa heat shock protein, mitochondrial [Mus musculus]","gi|206597442|ref|NM_022229.2|",2073,0,"Rattus norvegicus heat shock protein family D member 1 (Hspd1), mRNA","P63039",1083,0,"60 kDa heat shock protein, mitochondrial","SPAC12G12.04",594,0,"COG0459","pfam00118","Cpn60_TCP1","TCP-1/cpn60 chaperonin family. This family includes members from the HSP60 chaperone family and the TCP-1 (T-complex protein) family.",".",".",".",".","."]
["ENSRNOG00000019208",339,21.80801854,61,3.938273439,5.537456676,2.469223506,{"v":1.00316E-47,"d":"1.00E-47"},{"v":3.1121e-47,"d":"3.11E-47"},"up","yes","P2rx5","protein_coding","chr10:57777819-57789423:+","gi|149053319|gb|EDM05136.1|",2314,0,"purinergic receptor P2X, ligand-gated ion channel, 5 [Rattus norvegicus]","gi|31377507|ref|NM_080780.2|",2387,0,"Rattus norvegicus purinergic receptor P2X 5 (P2rx5), mRNA","P51578",893,0,"P2X purinoceptor 5",".",".",".",".","pfam00864","P2X_receptor","ATP P2X receptor.","GO:0006812|cation transport;GO:0009268|response to pH;GO:0010043|response to zinc ion;GO:0033198|response to ATP;GO:0035590|purinergic nucleotide receptor signaling pathway;GO:0043416|regulation of skeletal muscle tissue regeneration;GO:0048630|skeletal muscle tissue growth;GO:0051592|response to calcium ion;GO:0060079|excitatory postsynaptic potential;GO:0098655|cation transmembrane transport;GO:1905665|positive regulation of calcium ion import across plasma membrane;","GO:0005639|integral component of nuclear inner membrane;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0098794|postsynapse;","GO:0001614|purinergic nucleotide receptor activity;GO:0004931|extracellularly ATP-gated cation channel activity;GO:0005244|voltage-gated ion channel activity;GO:0005524|ATP binding;GO:0042802|identical protein binding;","K05219","P2RX5; P2X purinoceptor 5"]
["ENSRNOG00000017424",269,17.30488787,32,2.065979509,8.376117864,3.066281743,{"v":1.71712e-47,"d":"1.72E-47"},{"v":5.3097e-47,"d":"5.31E-47"},"up","yes","Chrna2","protein_coding","chr15:40342317-40358601:+","gi|672078229|ref|XP_008768957.1|",2690,0,"PREDICTED: neuronal acetylcholine receptor subunit alpha-2 isoform X1 [Rattus norvegicus]","gi|19173791|ref|NM_133420.1|",1931,0,"Rattus norvegicus cholinergic receptor nicotinic alpha 2 subunit (Chrna2), mRNA","P12389",990,0,"Neuronal acetylcholine receptor subunit alpha-2",".",".",".",".","pfam02931","Neur_chan_LBD","Neurotransmitter-gated ion-channel ligand binding domain. This family is the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.","GO:0007165|signal transduction;GO:0007268|chemical synaptic transmission;GO:0007271|synaptic transmission, cholinergic;GO:0034220|ion transmembrane transport;GO:0035094|response to nicotine;GO:0042391|regulation of membrane potential;GO:0050877|nervous system process;GO:0060079|excitatory postsynaptic potential;","GO:0005887|integral component of plasma membrane;GO:0005892|acetylcholine-gated channel complex;GO:0016020|membrane;GO:0032991|protein-containing complex;GO:0043005|neuron projection;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0071944|cell periphery;","GO:0015464|acetylcholine receptor activity;GO:0022848|acetylcholine-gated cation-selective channel activity;GO:0030594|neurotransmitter receptor activity;","K04804","CHRNA2; nicotinic acetylcholine receptor alpha-2"]
["ENSRNOG00000043201",796,51.2070288,319,20.59523323,2.486353431,1.314031387,{"v":2.24128e-47,"d":"2.24E-47"},{"v":6.91927e-47,"d":"6.92E-47"},"up","yes","Coq8a","protein_coding","chr13:91904739-91931431:-","gi|61557218|ref|NP_001013203.1|",3358,0,"atypical kinase ADCK3, mitochondrial [Rattus norvegicus]","gi|61557217|ref|NM_001013185.1|",2490,0,"Rattus norvegicus aarF domain containing kinase 3 (Adck3), mRNA","Q5BJQ0",1298,0,"Atypical kinase COQ8A, mitochondrial","SPBC2D10.18",375,{"v":1E-117,"d":"1.00E-117"},"COG0661","pfam03109","ABC1","ABC1 family. This family includes ABC1 from yeast and AarF from Escherichia coli. These proteins have a nuclear or mitochondrial subcellular location in eukaryotes. The exact molecular functions of these proteins is not clear, however yeast ABC1 suppresses a cytochrome b mRNA translation defect and is essential for the electron transfer in the bc 1 complex and Escherichia coli AarF is required for ubiquinone production. It has been suggested that members of the ABC1 family are novel chaperonins. These proteins are unrelated to the ABC transporter proteins.","GO:0006744|ubiquinone biosynthetic process;GO:0016310|phosphorylation;","GO:0005739|mitochondrion;GO:0016021|integral component of membrane;GO:0031314|extrinsic component of mitochondrial inner membrane;","GO:0005524|ATP binding;GO:0016301|kinase activity;GO:0043531|ADP binding;","K08869","ADCK, ABC1; aarF domain-containing kinase"]
["ENSRNOG00000013436",676,43.48737621,246,15.88221748,2.738117412,1.453184312,{"v":6.59043e-47,"d":"6.59E-47"},{"v":2.0204e-46,"d":"2.02E-46"},"up","yes","Pde7b","protein_coding","chr1:15182704-15492900:-","gi|672033732|ref|XP_008756813.1|",2685,0,"PREDICTED: cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [Rattus norvegicus]","gi|672033731|ref|XM_008758591.1|",2073,0,"PREDICTED: Rattus norvegicus phosphodiesterase 7B (Pde7b), transcript variant X1, mRNA","Q9QXQ1",850,0,"cAMP-specific 3',5'-cyclic phosphodiesterase 7B",".",".",".",".","pfam00233","PDEase_I","3'5'-cyclic nucleotide phosphodiesterase.","GO:0007165|signal transduction;GO:0019933|cAMP-mediated signaling;",".","GO:0004114|3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0004115|3',5'-cyclic-AMP phosphodiesterase activity;GO:0046872|metal ion binding;","K18436","PDE7; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7 [EC:3.1.4.53]"]
["ENSRNOG00000014692",500,32.16521909,144,9.29690779,3.459776069,1.790678664,{"v":7.2256e-47,"d":"7.23E-47"},{"v":2.21156E-46,"d":"2.21E-46"},"up","yes","Mogat1","protein_coding","chr9:79956649-79988513:+","gi|229577408|ref|NP_080989.2|",1370,0,"2-acylglycerol O-acyltransferase 1 [Mus musculus]","gi|229577407|ref|NM_026713.3|",590,0,"Mus musculus monoacylglycerol O-acyltransferase 1 (Mogat1), mRNA","Q91ZV4",532,0,"2-acylglycerol O-acyltransferase 1",".",".",".",".","pfam03982","DAGAT","Diacylglycerol acyltransferase. The terminal step of triacylglycerol (TAG) formation is catalysed by the enzyme diacylglycerol acyltransferase (DAGAT).","GO:0006629|lipid metabolic process;GO:0006651|diacylglycerol biosynthetic process;GO:0019432|triglyceride biosynthetic process;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016020|membrane;","GO:0003846|2-acylglycerol O-acyltransferase activity;GO:0004144|diacylglycerol O-acyltransferase activity;GO:0008374|O-acyltransferase activity;","K14458","MOGAT1, MGAT1; 2-acylglycerol O-acyltransferase 1 [EC:2.3.1.22]"]
["ENSRNOG00000019079",1142,73.46536041,555,35.83183211,2.050282,1.035822355,{"v":1.52556e-46,"d":"1.53E-46"},{"v":4.65186e-46,"d":"4.65E-46"},"up","yes","Polr1c","protein_coding","chr9:14735714-14739852:+","gi|149069364|gb|EDM18805.1|",1173,{"v":9e-155,"d":"9.00E-155"},"RNA polymerase 1-1, isoform CRA_b [Rattus norvegicus]","gi|56605737|ref|NM_001008330.1|",855,0,"Rattus norvegicus polymerase (RNA) I polypeptide C (Polr1c), mRNA","P52432",447,{"v":4e-152,"d":"4.00E-152"},"DNA-directed RNA polymerases I and III subunit RPAC1","SPBC1289.07c",225,{"v":1e-66,"d":"1.00E-66"},"COG0202","pfam01193","RNA_pol_L","RNA polymerase Rpb3/Rpb11 dimerization domain. The two eukaryotic subunits Rpb3 and Rpb11 dimerise to from a platform onto which the other subunits of the RNA polymerase assemble (D/L in archaea). The prokaryotic equivalent of the Rpb3/Rpb11 platform is the alpha-alpha dimer. The dimerization domain of the alpha subunit/Rpb3 is interrupted by an insert domain (pfam01000). Some of the alpha subunits also contain iron-sulphur binding domains (pfam00037). Rpb11 is found as a continuous domain. Members of this family include: alpha subunit from eubacteria, alpha subunits from chloroplasts, Rpb3 subunits from eukaryotes, Rpb11 subunits from eukaryotes, RpoD subunits from archaeal spp, and RpoL subunits from archaeal spp.","GO:0006360|transcription by RNA polymerase I;GO:0006383|transcription by RNA polymerase III;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005666|RNA polymerase III complex;GO:0005736|RNA polymerase I complex;","GO:0001054|RNA polymerase I activity;GO:0001056|RNA polymerase III activity;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0003899|DNA-directed 5'-3' RNA polymerase activity;GO:0046983|protein dimerization activity;","K03027","RPAC1, RPC40, POLR1C; DNA-directed RNA polymerases I and III subunit RPAC1"]
["ENSRNOG00000024082",617,39.69188036,212,13.68711425,2.899945134,1.536025605,{"v":1.69941E-46,"d":"1.70E-46"},{"v":5.17646e-46,"d":"5.18E-46"},"up","yes","Gldn","protein_coding","chr8:54679119-54723196:+","gi|149041693|gb|EDL95534.1|",2502,0,"gliomedin, isoform CRA_b [Rattus norvegicus]","gi|31341231|ref|NM_181382.2|",2309,0,"Rattus norvegicus gliomedin (Gldn), mRNA","Q80WL1",964,0,"Gliomedin",".",".",".",".","pfam02191","OLF","Olfactomedin-like domain.","GO:0032528|microvillus organization;GO:0034113|heterotypic cell-cell adhesion;GO:0045162|clustering of voltage-gated sodium channels;","GO:0005581|collagen trimer;GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0030424|axon;","GO:0086080|protein binding involved in heterotypic cell-cell adhesion;","K16364","GLDN; gliomedin"]
["ENSRNOG00000046493",1052,67.67562097,494,31.89355867,2.121921284,1.085371138,{"v":2.7729e-46,"d":"2.77E-46"},{"v":8.39707e-46,"d":"8.40E-46"},"up","yes","Pnpo","protein_coding","chr10:81924569-81930871:-","gi|12018270|ref|NP_072123.1|",1406,0,"pyridoxine-5'-phosphate oxidase [Rattus norvegicus]","gi|56799406|ref|NM_022601.2|",2044,0,"Rattus norvegicus pyridoxamine 5'-phosphate oxidase (Pnpo), mRNA","O88794",546,0,"Pyridoxine-5'-phosphate oxidase","all1248",194,{"v":2e-56,"d":"2.00E-56"},"COG0259","pfam01243","Pyridox_oxidase","Pyridoxamine 5'-phosphate oxidase.","GO:0008615|pyridoxine biosynthetic process;GO:0042823|pyridoxal phosphate biosynthetic process;",".","GO:0004733|pyridoxamine-phosphate oxidase activity;GO:0010181|FMN binding;GO:0030170|pyridoxal phosphate binding;GO:0042803|protein homodimerization activity;","K00275","pdxH, PNPO; pyridoxamine 5'-phosphate oxidase [EC:1.4.3.5]"]
["ENSRNOG00000049629",757,48.69814171,299,19.30399604,2.522697457,1.334967196,{"v":3.27835e-46,"d":"3.28E-46"},{"v":9.90146e-46,"d":"9.90E-46"},"up","yes","Reep2","protein_coding","chr18:26438346-26447161:+","gi|532025987|ref|XP_005355979.1|",1223,{"v":2E-160,"d":"2.00E-160"},"PREDICTED: receptor expression-enhancing protein 2 isoform X1 [Microtus ochrogaster]","gi|114158667|ref|NM_001048047.1|",1751,0,"Rattus norvegicus receptor accessory protein 2 (Reep2), mRNA","Q8VCD6",461,{"v":2e-156,"d":"2.00E-156"},"Receptor expression-enhancing protein 2","SPBC30D10.09c",65.9,{"v":3E-11,"d":"3.00E-11"},"COG5052","pfam03134","TB2_DP1_HVA22","TB2/DP1, HVA22 family. This family includes members from a wide variety of eukaryotes. It includes the TB2/DP1 (deleted in polyposis) protein, which in humans is deleted in severe forms of familial adenomatous polyposis, an autosomal dominant oncological inherited disease. The family also includes the plant protein of known similarity to TB2/DP1, the HVA22 abscisic acid-induced protein, which is thought to be a regulatory protein.","GO:0032386|regulation of intracellular transport;GO:0032596|protein transport into membrane raft;GO:0050913|sensory perception of bitter taste;GO:0050916|sensory perception of sweet taste;GO:0071786|endoplasmic reticulum tubular network organization;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005881|cytoplasmic microtubule;GO:0005887|integral component of plasma membrane;","GO:0031883|taste receptor binding;","K17338","REEP1_2_3_4; receptor expression-enhancing protein 1/2/3/4"]
["ENSRNOG00000024577",448,28.82003631,118,7.618299439,3.783001251,1.919531253,{"v":3.56949e-46,"d":"3.57E-46"},{"v":1.07694E-45,"d":"1.08E-45"},"up","yes","Gamt","protein_coding","chr7:9448628-9451778:+","gi|403310680|ref|NP_036925.2|",1251,{"v":3e-169,"d":"3.00E-169"},"guanidinoacetate N-methyltransferase [Rattus norvegicus]","gi|403310679|ref|NM_012793.2|",1345,0,"Rattus norvegicus guanidinoacetate N-methyltransferase (Gamt), mRNA","P10868",481,{"v":7e-169,"d":"7.00E-169"},"Guanidinoacetate N-methyltransferase",".",".",".",".","pfam13659","Methyltransf_26","Methyltransferase domain. This family contains methyltransferase domains.","GO:0006601|creatine biosynthetic process;GO:0007283|spermatogenesis;GO:0009887|animal organ morphogenesis;GO:0032259|methylation;GO:0040014|regulation of multicellular organism growth;GO:0046498|S-adenosylhomocysteine metabolic process;GO:0046500|S-adenosylmethionine metabolic process;GO:1990402|embryonic liver development;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0008757|S-adenosylmethionine-dependent methyltransferase activity;GO:0030731|guanidinoacetate N-methyltransferase activity;GO:0042802|identical protein binding;","K00542","GAMT; guanidinoacetate N-methyltransferase [EC:2.1.1.2]"]
["ENSRNOG00000009848",974,62.65784679,443,28.60090383,2.190764571,1.131434454,{"v":7.5941e-46,"d":"7.59E-46"},{"v":2.27915e-45,"d":"2.28E-45"},"up","yes","Il18","protein_coding","chr8:50906960-50932887:+","gi|755528372|ref|XP_011240703.1|",1060,{"v":7e-141,"d":"7.00E-141"},"PREDICTED: interleukin-18 isoform X2 [Mus musculus]","gi|18699020|gb|AY077842.1|",749,0,"Rattus norvegicus IFN-gamma-inducing factor IL-18 (Il18) mRNA, complete cds","P97636",398,{"v":1e-137,"d":"1.00E-137"},"Interleukin-18",".",".",".",".","pfam00340","IL1","Interleukin-1 / 18. This family includes interleukin-1 and interleukin-18.","GO:0000165|MAPK cascade;GO:0001525|angiogenesis;GO:0001649|osteoblast differentiation;GO:0001666|response to hypoxia;GO:0006954|inflammatory response;GO:0007611|learning or memory;GO:0008283|cell proliferation;GO:0008284|positive regulation of cell proliferation;GO:0008625|extrinsic apoptotic signaling pathway via death domain receptors;GO:0009314|response to radiation;GO:0009409|response to cold;GO:0010628|positive regulation of gene expression;GO:0010744|positive regulation of macrophage derived foam cell differentiation;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0014911|positive regulation of smooth muscle cell migration;GO:0030101|natural killer cell activation;GO:0030155|regulation of cell adhesion;GO:0030324|lung development;GO:0030431|sleep;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0032148|activation of protein kinase B activity;GO:0032722|positive regulation of chemokine production;GO:0032725|positive regulation of granulocyte macrophage colony-stimulating factor production;GO:0032729|positive regulation of interferon-gamma production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032740|positive regulation of interleukin-17 production;GO:0032757|positive regulation of interleukin-8 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032819|positive regulation of natural killer cell proliferation;GO:0032930|positive regulation of superoxide anion generation;GO:0032967|positive regulation of collagen biosynthetic process;GO:0033030|negative regulation of neutrophil apoptotic process;GO:0035655|interleukin-18-mediated signaling pathway;GO:0042088|T-helper 1 type immune response;GO:0042104|positive regulation of activated T cell proliferation;GO:0042119|neutrophil activation;GO:0042267|natural killer cell mediated cytotoxicity;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0042632|cholesterol homeostasis;GO:0043065|positive regulation of apoptotic process;GO:0043117|positive regulation of vascular permeability;GO:0043434|response to peptide hormone;GO:0043525|positive regulation of neuron apoptotic process;GO:0045188|regulation of circadian sleep/wake cycle, non-REM sleep;GO:0045630|positive regulation of T-helper 2 cell differentiation;GO:0045662|negative regulation of myoblast differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048546|digestive tract morphogenesis;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0050732|negative regulation of peptidyl-tyrosine phosphorylation;GO:0050966|detection of mechanical stimulus involved in sensory perception of pain;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051142|positive regulation of NK T cell proliferation;GO:0051897|positive regulation of protein kinase B signaling;GO:0055093|response to hyperoxia;GO:0070301|cellular response to hydrogen peroxide;GO:0070328|triglyceride homeostasis;GO:0071222|cellular response to lipopolysaccharide;GO:0071260|cellular response to mechanical stimulus;GO:0071320|cellular response to cAMP;GO:0071346|cellular response to interferon-gamma;GO:0071356|cellular response to tumor necrosis factor;GO:0071374|cellular response to parathyroid hormone stimulus;GO:0071375|cellular response to peptide hormone stimulus;GO:0071407|cellular response to organic cyclic compound;GO:0097421|liver regeneration;GO:0120162|positive regulation of cold-induced thermogenesis;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:2000256|positive regulation of male germ cell proliferation;GO:2000347|positive regulation of hepatocyte proliferation;GO:2000504|positive regulation of blood vessel remodeling;GO:2000556|positive regulation of T-helper 1 cell cytokine production;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0016324|apical plasma membrane;","GO:0005125|cytokine activity;GO:0005515|protein binding;GO:0045515|interleukin-18 receptor binding;","K05482","IL18, IL1F4; interleukin 18"]
["ENSRNOG00000007426",317,20.3927489,55,3.550902281,5.742976655,2.521798697,{"v":8.78353e-46,"d":"8.78E-46"},{"v":2.62922e-45,"d":"2.63E-45"},"up","yes","Tmem64","protein_coding","chr5:28698918-28745330:+","gi|392340363|ref|XP_003754051.1|",1291,{"v":3e-172,"d":"3.00E-172"},"PREDICTED: transmembrane protein 64 [Rattus norvegicus]","gi|672019166|ref|XM_003754003.3|",1375,0,"PREDICTED: Rattus norvegicus transmembrane protein 64 (Tmem64), mRNA","Q3U145",466,{"v":1e-159,"d":"1.00E-159"},"Transmembrane protein 64","slr0305",63.5,{"v":1E-10,"d":"1.00E-10"},"COG0398","pfam09335","SNARE_assoc","SNARE associated Golgi protein. This is a family of SNARE associated Golgi proteins. The yeast member of this family localizes with the t-SNARE Tlg2.","GO:0043462|regulation of ATPase activity;GO:0045600|positive regulation of fat cell differentiation;GO:0045668|negative regulation of osteoblast differentiation;GO:0045672|positive regulation of osteoclast differentiation;GO:0045780|positive regulation of bone resorption;GO:0051480|regulation of cytosolic calcium ion concentration;GO:0090090|negative regulation of canonical Wnt signaling pathway;","GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000021478",438,28.17673192,114,7.360052001,3.828333268,1.936716426,{"v":1.06037E-45,"d":"1.06E-45"},{"v":3.16909e-45,"d":"3.17E-45"},"up","yes","Tpd52l1","protein_coding","chr1:26172170-26291109:+","gi|112983804|ref|NP_001037760.1|",859,{"v":8e-110,"d":"8.00E-110"},"tumor protein D53 [Rattus norvegicus]","gi|672034060|ref|XM_006227737.2|",1571,0,"PREDICTED: Rattus norvegicus tumor protein D52-like 1 (Tpd52l1), transcript variant X2, mRNA","O54818",298,{"v":2e-96,"d":"2.00E-96"},"Tumor protein D53",".",".",".",".","pfam04201","TPD52","tumor protein D52 family. The hD52 gene was originally identified through its elevated expression level in human breast carcinoma. Cloning of D52 homologues from other species has indicated that D52 may play roles in calcium-mediated signal transduction and cell proliferation. Two human homologues of hD52, hD53 and hD54, have also been identified, demonstrating the existence of a novel gene/protein family. These proteins have an amino terminal coiled-coil that allows members to form homo- and heterodimers with each other.","GO:0000086|G2/M transition of mitotic cell cycle;GO:0043406|positive regulation of MAP kinase activity;GO:0046330|positive regulation of JNK cascade;GO:2001235|positive regulation of apoptotic signaling pathway;","GO:0005737|cytoplasm;GO:0048471|perinuclear region of cytoplasm;","GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;",".","."]
["ENSRNOG00000008766",198,12.73742676,9,0.581056737,21.92114118,4.454250999,{"v":1.14331E-45,"d":"1.14E-45"},{"v":3.41518e-45,"d":"3.42E-45"},"up","yes","Grin2b","protein_coding","chr4:168599546-169042279:-","gi|149049163|gb|EDM01617.1|",7896,0,"glutamate receptor, ionotropic, N-methyl D-aspartate 2B, isoform CRA_a [Rattus norvegicus]","gi|6980983|ref|NM_012574.1|",5253,0,"Rattus norvegicus glutamate ionotropic receptor NMDA type subunit 2B (Grin2b), mRNA","Q00960",3041,0,"Glutamate receptor ionotropic, NMDA 2B",".",".",".",".","pfam10565","NMDAR2_C","N-methyl D-aspartate receptor 2B3 C-terminus. This domain is found at the C-terminus of many NMDA-receptor proteins, many of which also carry the Ligated ion-channel family pfam00060 further upstream as well as the ANF_receptor family pfam01094. This region is predicted to be a large extra-cellular domain of the NMDA receptor proteins, being highly hydrophilic, and is thought to be integrally involved in the function of the receptor. The region also carries a number of potential N-glycosylation sites.","GO:0001508|action potential;GO:0001662|behavioral fear response;GO:0001666|response to hypoxia;GO:0001701|in utero embryonic development;GO:0001964|startle response;GO:0001967|suckling behavior;GO:0001975|response to amphetamine;GO:0006812|cation transport;GO:0006816|calcium ion transport;GO:0007268|chemical synaptic transmission;GO:0007423|sensory organ development;GO:0007611|learning or memory;GO:0007612|learning;GO:0007613|memory;GO:0007616|long-term memory;GO:0008306|associative learning;GO:0009612|response to mechanical stimulus;GO:0009636|response to toxic substance;GO:0009743|response to carbohydrate;GO:0010042|response to manganese ion;GO:0010243|response to organonitrogen compound;GO:0010350|cellular response to magnesium starvation;GO:0010738|regulation of protein kinase A signaling;GO:0010942|positive regulation of cell death;GO:0014049|positive regulation of glutamate secretion;GO:0014070|response to organic cyclic compound;GO:0014075|response to amine;GO:0019722|calcium-mediated signaling;GO:0021766|hippocampus development;GO:0021987|cerebral cortex development;GO:0032026|response to magnesium ion;GO:0033555|multicellular organismal response to stress;GO:0034097|response to cytokine;GO:0035235|ionotropic glutamate receptor signaling pathway;GO:0042220|response to cocaine;GO:0042596|fear response;GO:0043113|receptor clustering;GO:0043408|regulation of MAPK cascade;GO:0045471|response to ethanol;GO:0046960|sensitization;GO:0048167|regulation of synaptic plasticity;GO:0048169|regulation of long-term neuronal synaptic plasticity;GO:0048266|behavioral response to pain;GO:0048511|rhythmic process;GO:0050806|positive regulation of synaptic transmission;GO:0050966|detection of mechanical stimulus involved in sensory perception of pain;GO:0051290|protein heterotetramerization;GO:0051592|response to calcium ion;GO:0051597|response to methylmercury;GO:0051602|response to electrical stimulus;GO:0051707|response to other organism;GO:0060078|regulation of postsynaptic membrane potential;GO:0060079|excitatory postsynaptic potential;GO:0060291|long-term synaptic potentiation;GO:0060416|response to growth hormone;GO:0060992|response to fungicide;GO:0071230|cellular response to amino acid stimulus;GO:0071287|cellular response to manganese ion;GO:0071359|cellular response to dsRNA;GO:0071363|cellular response to growth factor stimulus;GO:0071386|cellular response to corticosterone stimulus;GO:0071396|cellular response to lipid;GO:0071407|cellular response to organic cyclic compound;GO:0097553|calcium ion transmembrane import into cytosol;GO:0098989|NMDA selective glutamate receptor signaling pathway;GO:0099566|regulation of postsynaptic cytosolic calcium ion concentration;GO:1901216|positive regulation of neuron death;GO:1902951|negative regulation of dendritic spine maintenance;GO:1904322|cellular response to forskolin;GO:1904644|cellular response to curcumin;GO:2001056|positive regulation of cysteine-type endopeptidase activity;","GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0005770|late endosome;GO:0005789|endoplasmic reticulum membrane;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0008021|synaptic vesicle;GO:0009986|cell surface;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0017146|NMDA selective glutamate receptor complex;GO:0030018|Z disc;GO:0042734|presynaptic membrane;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043083|synaptic cleft;GO:0043195|terminal bouton;GO:0043197|dendritic spine;GO:0044307|dendritic branch;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0097060|synaptic membrane;GO:0097440|apical dendrite;GO:0098686|hippocampal mossy fiber to CA3 synapse;GO:0098688|parallel fiber to Purkinje cell synapse;GO:0098794|postsynapse;GO:0098839|postsynaptic density membrane;GO:0098978|glutamatergic synapse;GO:0099056|integral component of presynaptic membrane;GO:0099061|integral component of postsynaptic density membrane;","GO:0004970|ionotropic glutamate receptor activity;GO:0004972|NMDA glutamate receptor activity;GO:0005102|signaling receptor binding;GO:0005149|interleukin-1 receptor binding;GO:0005234|extracellularly glutamate-gated ion channel activity;GO:0005261|cation channel activity;GO:0005262|calcium channel activity;GO:0005515|protein binding;GO:0008013|beta-catenin binding;GO:0008270|zinc ion binding;GO:0015276|ligand-gated ion channel activity;GO:0016594|glycine binding;GO:0016595|glutamate binding;GO:0022849|glutamate-gated calcium ion channel activity;GO:0031749|D2 dopamine receptor binding;GO:0035255|ionotropic glutamate receptor binding;GO:0036094|small molecule binding;GO:0038023|signaling receptor activity;GO:0042165|neurotransmitter binding;GO:0044877|protein-containing complex binding;GO:0050839|cell adhesion molecule binding;GO:0097110|scaffold protein binding;GO:0099529|neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential;GO:0099583|neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration;GO:1901363|heterocyclic compound binding;GO:1904315|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K05210","GRIN2B; glutamate receptor ionotropic, NMDA 2B"]
["ENSRNOG00000031211",186,11.9654615,3,0.193685579,61.7777615,5.949015691,{"v":1.37596E-45,"d":"1.38E-45"},{"v":4.09725e-45,"d":"4.10E-45"},"up","yes","Acsm5","protein_coding","chr1:173863041-173898588:+","gi|33086508|gb|AAP92566.1|",5048,0,"Aa2-174 [Rattus norvegicus]","gi|33086665|gb|AY325244.1|",2865,0,"Rattus norvegicus Cc1-38 mRNA, complete cds","Q6AYT9",1127,0,"Acyl-coenzyme A synthetase ACSM5, mitochondrial","MA2912",363,{"v":8e-113,"d":"8.00E-113"},"COG0365","pfam00501","AMP-binding","AMP-binding enzyme.","GO:0006633|fatty acid biosynthetic process;GO:0006637|acyl-CoA metabolic process;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005759|mitochondrial matrix;","GO:0003674|molecular_function;GO:0004321|fatty-acyl-CoA synthase activity;GO:0005524|ATP binding;GO:0005525|GTP binding;GO:0015645|fatty acid ligase activity;GO:0031956|medium-chain fatty acid-CoA ligase activity;GO:0046872|metal ion binding;GO:0047760|butyrate-CoA ligase activity;","K01896","ACSM; medium-chain acyl-CoA synthetase [EC:6.2.1.2]"]
["ENSRNOG00000047697",638,41.04281956,228,14.720104,2.788215325,1.47934198,{"v":1.61217e-45,"d":"1.61E-45"},{"v":4.79564e-45,"d":"4.80E-45"},"up","yes","Ggt1","protein_coding","chr20:13074700-13108442:-","gi|145280505|ref|NP_446292.2|",2936,0,"gamma-glutamyltranspeptidase 1 [Rattus norvegicus]","gi|145280504|ref|NM_053840.2|",2042,0,"Rattus norvegicus gamma-glutamyltransferase 1 (Ggt1), mRNA","P07314",1135,0,"Glutathione hydrolase 1 proenzyme","SPAC664.09",372,{"v":4e-117,"d":"4.00E-117"},"COG0405","pfam01019","G_glu_transpept","Gamma-glutamyltranspeptidase.","GO:0002682|regulation of immune system process;GO:0006412|translation;GO:0006508|proteolysis;GO:0006520|cellular amino acid metabolic process;GO:0006536|glutamate metabolic process;GO:0006631|fatty acid metabolic process;GO:0006691|leukotriene metabolic process;GO:0006750|glutathione biosynthetic process;GO:0006751|glutathione catabolic process;GO:0007283|spermatogenesis;GO:0007568|aging;GO:0019344|cysteine biosynthetic process;GO:0031179|peptide modification;GO:0031638|zymogen activation;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0034599|cellular response to oxidative stress;GO:0034612|response to tumor necrosis factor;GO:0050727|regulation of inflammatory response;GO:0061017|hepatoblast differentiation;GO:0070365|hepatocyte differentiation;GO:0097305|response to alcohol;GO:0097421|liver regeneration;GO:1901750|leukotriene D4 biosynthetic process;","GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0031982|vesicle;","GO:0000048|peptidyltransferase activity;GO:0002951|leukotriene-C(4) hydrolase;GO:0016746|transferase activity, transferring acyl groups;GO:0016755|transferase activity, transferring amino-acyl groups;GO:0036374|glutathione hydrolase activity;GO:0102953|hypoglycin A gamma-glutamyl transpeptidase activity;GO:0103068|leukotriene C4 gamma-glutamyl transferase activity;","K18592","GGT1_5, CD224; gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase [EC:2.3.2.2 3.4.19.13 3.4.19.14]"]
["ENSRNOG00000012862",606,38.98424554,209,13.49342867,2.889128219,1.530634232,{"v":1.79502e-45,"d":"1.80E-45"},{"v":5.33399e-45,"d":"5.33E-45"},"up","yes","Spsb4","protein_coding","chr8:97536520-97609787:-","gi|21553087|ref|NP_660116.1|",1424,0,"SPRY domain-containing SOCS box protein 4 [Mus musculus]","gi|197927328|ref|NM_001106849.2|",2243,0,"Rattus norvegicus splA/ryanodine receptor domain and SOCS box containing 4 (Spsb4), mRNA","Q8R5B6",553,0,"SPRY domain-containing SOCS box protein 4",".",".",".",".","pfam00622","SPRY","SPRY domain. SPRY Domain is named from SPla and the RYanodine Receptor. Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.","GO:0006511|ubiquitin-dependent protein catabolic process;GO:0016567|protein ubiquitination;GO:0035556|intracellular signal transduction;GO:0042752|regulation of circadian rhythm;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:1902916|positive regulation of protein polyubiquitination;","GO:0005829|cytosol;GO:0019005|SCF ubiquitin ligase complex;","GO:1990756|protein binding, bridging involved in substrate recognition for ubiquitination;","K10343","SPSB1_4, SSB1, SSB4; SPRY domain-containing SOCS box protein 1/4"]
["ENSRNOG00000015518",337,21.67935767,65,4.196520878,5.166031172,2.369056349,{"v":2.62053e-45,"d":"2.62E-45"},{"v":7.77488e-45,"d":"7.77E-45"},"up","yes","Rbp4","protein_coding","chr1:235893917-235901399:-","gi|226958688|ref|NP_001152959.1|",1152,{"v":4e-156,"d":"4.00E-156"},"retinol-binding protein 4 isoform 1 [Mus musculus]","gi|158187534|ref|NM_013162.1|",873,0,"Rattus norvegicus retinol binding protein 4 (Rbp4), mRNA","P04916",388,{"v":1E-134,"d":"1.00E-134"},"Retinol-binding protein 4",".",".",".",".","pfam00061","Lipocalin","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.","GO:0001654|eye development;GO:0002639|positive regulation of immunoglobulin production;GO:0006094|gluconeogenesis;GO:0007283|spermatogenesis;GO:0007507|heart development;GO:0008584|male gonad development;GO:0030277|maintenance of gastrointestinal epithelium;GO:0030324|lung development;GO:0032024|positive regulation of insulin secretion;GO:0032526|response to retinoic acid;GO:0032868|response to insulin;GO:0034633|retinol transport;GO:0042572|retinol metabolic process;GO:0042574|retinal metabolic process;GO:0042593|glucose homeostasis;GO:0045471|response to ethanol;GO:0048562|embryonic organ morphogenesis;GO:0048706|embryonic skeletal system development;GO:0048738|cardiac muscle tissue development;GO:0048807|female genitalia morphogenesis;GO:0050908|detection of light stimulus involved in visual perception;GO:0060041|retina development in camera-type eye;GO:0060044|negative regulation of cardiac muscle cell proliferation;GO:0060059|embryonic retina morphogenesis in camera-type eye;GO:0060065|uterus development;GO:0060068|vagina development;GO:0060157|urinary bladder development;GO:0060347|heart trabecula formation;GO:0071939|vitamin A import;","GO:0005615|extracellular space;GO:0032991|protein-containing complex;","GO:0016918|retinal binding;GO:0019841|retinol binding;GO:0034632|retinol transmembrane transporter activity;GO:0044877|protein-containing complex binding;","K18271","RBP4; retinol-binding protein 4"]
["ENSRNOG00000069925",900,57.89739437,396,25.56649642,2.2645807,1.179243952,{"v":2.76575e-45,"d":"2.77E-45"},{"v":8.20149e-45,"d":"8.20E-45"},"up","yes","ENSRNOG00000069925","protein_coding","chr3:108098346-108130565:+","gi|58865490|ref|NP_001011956.1|",3337,0,"tRNA wybutosine-synthesizing protein 4 [Rattus norvegicus]","gi|323339246|gb|AC243463.5|",5101,0,"Rattus norvegicus Y Chr BAC RNAEX-201K15 (Amplicon Express Rat SHR-Akr BAC library) complete sequence","Q5XIA3",1290,0,"tRNA wybutosine-synthesizing protein 4",".",".",".",".","pfam00607","Gag_p24","gag gene protein p24 (core nucleocapsid protein). p24 forms inner protein layer of the nucleocapsid. ELISA tests for p24 is the most commonly used method to demonstrate virus replication both in vivo and in vitro.",".",".",".",".","."]
["ENSRNOG00000038319",639,41.10715,230,14.84922772,2.768302216,1.469001451,{"v":3.92835e-45,"d":"3.93E-45"},{"v":1.16369E-44,"d":"1.16E-44"},"up","yes","Akr1c19","protein_coding","chr17:66004002-66025047:+","gi|154756742|ref|NP_001094046.1|",1741,0,"aldo-keto reductase family 1, member C19 [Rattus norvegicus]","gi|154756741|ref|NM_001100576.1|",1355,0,"Rattus norvegicus aldo-keto reductase family 1, member C19 (Akr1c19), mRNA","Q95JH6",498,{"v":3e-174,"d":"3.00E-174"},"Aldo-keto reductase family 1 member C1 homolog","YOR120w",206,{"v":4e-61,"d":"4.00E-61"},"COG0656","pfam00248","Aldo_ket_red","Aldo/keto reductase family. This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.","GO:0008202|steroid metabolic process;","GO:0005829|cytosol;","GO:0004032|alditol:NADP+ 1-oxidoreductase activity;GO:0016229|steroid dehydrogenase activity;GO:0047086|ketosteroid monooxygenase activity;GO:0047834|D-threo-aldose 1-dehydrogenase activity;",".","."]
["ENSRNOG00000014310",1066,68.57624711,510,32.92654842,2.082703787,1.058457667,{"v":4.54883e-45,"d":"4.55E-45"},{"v":1.34262E-44,"d":"1.34E-44"},"up","yes","Tmtc4","protein_coding","chr15:100000152-100056543:-","gi|564387694|ref|XP_006252585.1|",3747,0,"PREDICTED: transmembrane and TPR repeat-containing protein 4 isoform X1 [Rattus norvegicus]","gi|672079163|ref|XM_006252523.2|",3327,0,"PREDICTED: Rattus norvegicus transmembrane and tetratricopeptide repeat containing 4 (Tmtc4), transcript variant X1, mRNA","Q8BG19",1367,0,"Transmembrane and TPR repeat-containing protein 4",".",".",".",".","pfam08409","DUF1736","Domain of unknown function (DUF1736). This domain of unknown function is found in various hypothetical metazoan proteins.","GO:0007605|sensory perception of sound;GO:0030968|endoplasmic reticulum unfolded protein response;GO:0032470|positive regulation of endoplasmic reticulum calcium ion concentration;GO:0035269|protein O-linked mannosylation;GO:1905584|outer hair cell apoptotic process;","GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;","GO:0000030|mannosyltransferase activity;GO:0004169|dolichyl-phosphate-mannose-protein mannosyltransferase activity;GO:0051117|ATPase binding;","K23424","TMTC; protein O-mannosyl-transferase [EC:2.4.1.-]"]
["ENSRNOG00000000653",792,50.94970704,327,21.11172811,2.413336643,1.271029175,{"v":7.30784e-45,"d":"7.31E-45"},{"v":2.14698e-44,"d":"2.15E-44"},"up","yes","Nr5a2","protein_coding","chr13:48316301-48433326:-","gi|13492975|ref|NP_068510.1|",2876,0,"nuclear receptor subfamily 5 group A member 2 [Rattus norvegicus]","gi|13492974|ref|NM_021742.1|",1928,0,"Rattus norvegicus nuclear receptor subfamily 5, group A, member 2 (Nr5a2), mRNA","Q9QWM1",1112,0,"Nuclear receptor subfamily 5 group A member 2",".",".",".",".","pfam00105","zf-C4","Zinc finger, C4 type (two domains). In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.","GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008206|bile acid metabolic process;GO:0009755|hormone-mediated signaling pathway;GO:0009888|tissue development;GO:0030522|intracellular receptor signaling pathway;GO:0030855|epithelial cell differentiation;GO:0042127|regulation of cell proliferation;GO:0042632|cholesterol homeostasis;GO:0045070|positive regulation of viral genome replication;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0061113|pancreas morphogenesis;GO:0097720|calcineurin-mediated signaling;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0090575|RNA polymerase II transcription factor complex;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003690|double-stranded DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0004879|nuclear receptor activity;GO:0005543|phospholipid binding;GO:0008270|zinc ion binding;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K08027","NR5A2, FTF; nuclear receptor subfamily 5 group A member 2"]
["ENSRNOG00000006611",298,19.17047058,49,3.163531123,6.059833089,2.599278057,{"v":1.46258E-44,"d":"1.46E-44"},{"v":4.28371E-44,"d":"4.28E-44"},"up","yes","Nostrin","protein_coding","chr3:53904827-53970988:+","gi|66730388|ref|NP_001019431.1|",2167,0,"nostrin [Rattus norvegicus]","gi|66730387|ref|NM_001024260.1|",1611,0,"Rattus norvegicus nitric oxide synthase trafficking (Nostrin), mRNA","Q5I0D6",839,0,"Nostrin",".",".",".",".","pfam14604","SH3_9","Variant SH3 domain.","GO:0006897|endocytosis;GO:0007165|signal transduction;GO:0008150|biological_process;GO:0045892|negative regulation of transcription, DNA-templated;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0031410|cytoplasmic vesicle;","GO:0003674|molecular_function;GO:0003677|DNA binding;","K20126","NOSTRIN; nostrin"]
["ENSRNOG00000061213",1003,64.5234295,470,30.34407404,2.126393095,1.088408325,{"v":2.10752E-44,"d":"2.11E-44"},{"v":6.15688e-44,"d":"6.16E-44"},"up","yes","Mrps36","protein_coding","chr2:31870551-31880730:-","gi|300797955|ref|NP_001178534.1|",469,{"v":9e-55,"d":"9.00E-55"},"28S ribosomal protein S36, mitochondrial [Rattus norvegicus]","gi|683428057|ref|NM_001191605.3|",802,0,"Rattus norvegicus mitochondrial ribosomal protein S36 (Mrps36), mRNA","Q9CQX8",170,{"v":2E-50,"d":"2.00E-50"},"28S ribosomal protein S36, mitochondrial",".",".",".",".","pfam10937","DUF2638","Protein of unknown function (DUF2638). This family of proteins has no known function.",".","GO:0005739|mitochondrion;GO:0005763|mitochondrial small ribosomal subunit;",".","K17414","MRPS36; small subunit ribosomal protein S36"]
["ENSRNOG00000029740",246,15.82528779,28,1.80773207,8.754221963,3.129978964,{"v":2.19038E-44,"d":"2.19E-44"},{"v":6.39568e-44,"d":"6.40E-44"},"up","yes","Slc35g1","protein_coding","chr1:236163175-236170262:+","gi|300798579|ref|NP_001178564.1|",1651,0,"solute carrier family 35 member G1 [Rattus norvegicus]","gi|300798578|ref|NM_001191635.1|",1104,0,"Rattus norvegicus solute carrier family 35, member G1 (Slc35g1), mRNA","Q8BY79",587,0,"Solute carrier family 35 member G1","YPL264c",80.1,{"v":2e-15,"d":"2.00E-15"},"COG0697","pfam00892","EamA","EamA-like transporter family. This family includes many hypothetical membrane proteins of unknown function.  Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6.","GO:0051480|regulation of cytosolic calcium ion concentration;GO:1990034|calcium ion export across plasma membrane;","GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000016351",1129,72.62906471,558,36.02551769,2.016044997,1.01152784,{"v":2.44662e-44,"d":"2.45E-44"},{"v":7.13657e-44,"d":"7.14E-44"},"up","yes","Frrs1","protein_coding","chr2:204823025-204895540:+","gi|672016242|ref|XP_008773478.1|",3035,0,"PREDICTED: ferric-chelate reductase 1 isoform X1 [Rattus norvegicus]","gi|672016241|ref|XM_008775256.1|",1886,0,"PREDICTED: Rattus norvegicus ferric-chelate reductase 1 (Frrs1), transcript variant X1, mRNA","Q8K385",1062,0,"Ferric-chelate reductase 1",".",".",".",".","pfam02014","Reeler","Reeler domain.","GO:0006879|cellular iron ion homeostasis;","GO:0016021|integral component of membrane;","GO:0016722|oxidoreductase activity, oxidizing metal ions;",".","."]
["ENSRNOG00000018615",384,24.70288826,91,5.875129229,4.204654451,2.071987241,{"v":7.81779e-44,"d":"7.82E-44"},{"v":2.26304e-43,"d":"2.26E-43"},"up","yes","Cenph","protein_coding","chr2:31894667-31910154:-","gi|672041340|ref|XP_008758923.1|",1138,{"v":2e-144,"d":"2.00E-144"},"PREDICTED: centromere protein H isoform X1 [Rattus norvegicus]","gi|672041339|ref|XM_008760701.1|",1187,0,"PREDICTED: Rattus norvegicus similar to centromere autoantigen H (LOC681185), transcript variant X1, mRNA","Q9QYM8",360,{"v":2e-114,"d":"2.00E-114"},"Centromere protein H",".",".",".",".","pfam05837","CENP-H","Centromere protein H (CENP-H). This family consists of several eukaryotic centromere protein H (CENP-H) sequences. Macromolecular centromere-kinetochore complex plays a critical role in sister chromatid separation, but its complete protein composition as well as its precise dynamic function during mitosis has not yet been clearly determined. CENP-H contains a coiled-coil structure and a nuclear localisation signal. CENP-H is specifically and constitutively localized in kinetochores throughout the cell cycle. CENP-H may play a role in kinetochore organisation and function throughout the cell cycle. This the C-terminus of the region, which is conserved from fungi to humans.","GO:0007052|mitotic spindle organization;GO:0007059|chromosome segregation;GO:0051382|kinetochore assembly;","GO:0000776|kinetochore;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005694|chromosome;GO:0005730|nucleolus;","GO:0043515|kinetochore binding;","K11500","CENPH; centromere protein H"]
["ENSRNOG00000010263",1109,71.34245595,547,35.31533723,2.020155024,1.014466008,{"v":8.75824e-44,"d":"8.76E-44"},{"v":2.52759e-43,"d":"2.53E-43"},"up","yes","Cldn11","protein_coding","chr2:112207745-112221050:-","gi|148703035|gb|EDL34982.1|",1012,{"v":9e-131,"d":"9.00E-131"},"claudin 11, partial [Mus musculus]","gi|61889102|ref|NM_053457.2|",1845,0,"Rattus norvegicus claudin 11 (Cldn11), mRNA","Q60771",352,{"v":3e-116,"d":"3.00E-116"},"Claudin-11",".",".",".",".","pfam00822","PMP22_Claudin","PMP-22/EMP/MP20/Claudin family.","GO:0007155|cell adhesion;GO:0007283|spermatogenesis;GO:0008366|axon ensheathment;GO:0016338|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;GO:0070830|bicellular tight junction assembly;GO:0120192|tight junction assembly;","GO:0005811|lipid droplet;GO:0005883|neurofilament;GO:0005886|plasma membrane;GO:0005923|bicellular tight junction;GO:0016021|integral component of membrane;GO:0030054|cell junction;GO:0030424|axon;GO:0045178|basal part of cell;GO:0070160|tight junction;","GO:0005198|structural molecule activity;GO:0042802|identical protein binding;","K06087","CLDN; claudin"]
["ENSRNOG00000007002",300,19.29913146,52,3.357216702,5.748551008,2.523198353,{"v":1.89932e-43,"d":"1.90E-43"},{"v":5.45655e-43,"d":"5.46E-43"},"up","yes","Lif","protein_coding","chr14:79134574-79140482:+","gi|162287188|ref|NP_071532.2|",1079,{"v":9e-135,"d":"9.00E-135"},"leukemia inhibitory factor precursor [Rattus norvegicus]","gi|672076932|ref|XM_006251364.2|",2002,0,"PREDICTED: Rattus norvegicus leukemia inhibitory factor (Lif), transcript variant X1, mRNA","P17777",410,{"v":2E-132,"d":"2.00E-132"},"Leukemia inhibitory factor",".",".",".",".","pfam01291","LIF_OSM","LIF / OSM family.","GO:0001974|blood vessel remodeling;GO:0006955|immune response;GO:0007260|tyrosine phosphorylation of STAT protein;GO:0007566|embryo implantation;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0010628|positive regulation of gene expression;GO:0010976|positive regulation of neuron projection development;GO:0016525|negative regulation of angiogenesis;GO:0019827|stem cell population maintenance;GO:0030324|lung development;GO:0031100|animal organ regeneration;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0033141|positive regulation of peptidyl-serine phosphorylation of STAT protein;GO:0033630|positive regulation of cell adhesion mediated by integrin;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0043410|positive regulation of MAPK cascade;GO:0045595|regulation of cell differentiation;GO:0045651|positive regulation of macrophage differentiation;GO:0045835|negative regulation of meiotic nuclear division;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046697|decidualization;GO:0046888|negative regulation of hormone secretion;GO:0048286|lung alveolus development;GO:0048644|muscle organ morphogenesis;GO:0048666|neuron development;GO:0048708|astrocyte differentiation;GO:0048711|positive regulation of astrocyte differentiation;GO:0048861|leukemia inhibitory factor signaling pathway;GO:0048863|stem cell differentiation;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0051461|positive regulation of corticotropin secretion;GO:0060041|retina development in camera-type eye;GO:0060135|maternal process involved in female pregnancy;GO:0060290|transdifferentiation;GO:0060426|lung vasculature development;GO:0060463|lung lobe morphogenesis;GO:0060707|trophoblast giant cell differentiation;GO:0060708|spongiotrophoblast differentiation;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0072108|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0072307|regulation of metanephric nephron tubule epithelial cell differentiation;GO:1900182|positive regulation of protein localization to nucleus;GO:1901676|positive regulation of histone H3-K27 acetylation;GO:1903025|regulation of RNA polymerase II regulatory region sequence-specific DNA binding;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005829|cytosol;","GO:0005102|signaling receptor binding;GO:0005125|cytokine activity;GO:0005146|leukemia inhibitory factor receptor binding;GO:0008083|growth factor activity;","K05419","LIF; leukemia inhibitory factor"]
["ENSRNOG00000050205",613,39.43455861,222,14.33273284,2.751363542,1.460146778,{"v":5.40716E-43,"d":"5.41E-43"},{"v":1.54487e-42,"d":"1.54E-42"},"up","yes","Afmid","protein_coding","chr10:103046180-103061718:+","gi|162462839|ref|NP_001104836.1|",1441,0,"kynurenine formamidase [Rattus norvegicus]","gi|162462838|ref|NM_001111366.1|",2508,0,"Rattus norvegicus arylformamidase (Afmid), mRNA","Q8K4H1",473,{"v":3e-159,"d":"3.00E-159"},"Kynurenine formamidase","mll5717",101,{"v":3e-22,"d":"3.00E-22"},"COG0657","pfam10983","DUF2793","Protein of unknown function (DUF2793). This is a bacterial family of proteins with unknown function.","GO:0019441|tryptophan catabolic process to kynurenine;GO:0034354|'de novo' NAD biosynthetic process from tryptophan;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004061|arylformamidase activity;GO:0016787|hydrolase activity;","K01432","AFMID; arylformamidase [EC:3.5.1.9]"]
["ENSRNOG00000011976",648,41.68612394,244,15.75309376,2.646218234,1.403932046,{"v":7.54189e-43,"d":"7.54E-43"},{"v":2.14833E-42,"d":"2.15E-42"},"up","yes","Nudt7","protein_coding","chr19:42125711-42151081:+","gi|149038257|gb|EDL92617.1|",1339,0,"nudix (nucleoside diphosphate linked moiety X)-type motif 7 (predicted), isoform CRA_d [Rattus norvegicus]","gi|779927948|ref|NM_001305427.1|",866,0,"Rattus norvegicus nudix hydrolase 7 (Nudt7), transcript variant 2, mRNA","Q99P30",374,{"v":2e-127,"d":"2.00E-127"},"Peroxisomal coenzyme A diphosphatase NUDT7","RSc0937",88.6,{"v":2E-19,"d":"2.00E-19"},"COG0494","pfam00293","NUDIX","NUDIX domain.","GO:0009132|nucleoside diphosphate metabolic process;GO:0015938|coenzyme A catabolic process;GO:0036114|medium-chain fatty-acyl-CoA catabolic process;GO:0044580|butyryl-CoA catabolic process;GO:0046356|acetyl-CoA catabolic process;GO:0050873|brown fat cell differentiation;GO:1901289|succinyl-CoA catabolic process;GO:1902858|propionyl-CoA metabolic process;GO:1902859|propionyl-CoA catabolic process;GO:2001294|malonyl-CoA catabolic process;","GO:0005777|peroxisome;","GO:0000287|magnesium ion binding;GO:0003986|acetyl-CoA hydrolase activity;GO:0010945|CoA pyrophosphatase activity;GO:0030145|manganese ion binding;GO:0030515|snoRNA binding;","K17879","NUDT7; peroxisomal coenzyme A diphosphatase NUDT7 [EC:3.6.1.-]"]
["ENSRNOG00000015082",218,14.02403552,20,1.291237193,10.86092904,3.441075611,{"v":9.48277e-43,"d":"9.48E-43"},{"v":2.69046e-42,"d":"2.69E-42"},"up","yes","Nlrp10","protein_coding","chr1:162922806-162930363:-","gi|157820755|ref|NP_001099761.1|",3520,0,"NACHT, LRR and PYD domains-containing protein 10 [Rattus norvegicus]","gi|157820754|ref|NM_001106291.1|",2541,0,"Rattus norvegicus NLR family, pyrin domain containing 10 (Nlrp10), mRNA","Q8CCN1",1157,0,"NACHT, LRR and PYD domains-containing protein 10",".",".",".",".","pfam05729","NACHT","NACHT domain. This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.","GO:0002827|positive regulation of T-helper 1 type immune response;GO:0032730|positive regulation of interleukin-1 alpha production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0050729|positive regulation of inflammatory response;GO:0050829|defense response to Gram-negative bacterium;GO:0050832|defense response to fungus;GO:1900426|positive regulation of defense response to bacterium;GO:2000318|positive regulation of T-helper 17 type immune response;","GO:0005737|cytoplasm;GO:0019897|extrinsic component of plasma membrane;","GO:0003924|GTPase activity;","K22266","NLRP10; NACHT, LRR and PYD domains-containing protein 10"]
["ENSRNOG00000015206",992,63.81579468,471,30.4086359,2.098607609,1.069432441,{"v":9.56848e-43,"d":"9.57E-43"},{"v":2.71343e-42,"d":"2.71E-42"},"up","yes","Alad","protein_coding","chr5:75961993-75972474:-","gi|6978483|ref|NP_037031.1|",1684,0,"delta-aminolevulinic acid dehydratase [Rattus norvegicus]","gi|298900881|emb|FQ213585.1|",1372,0,"Rattus norvegicus TL0AAA46YO18 mRNA sequence","P06214",653,0,"Delta-aminolevulinic acid dehydratase","SPAC1805.06c",341,{"v":7e-113,"d":"7.00E-113"},"COG0113","pfam00490","ALAD","Delta-aminolevulinic acid dehydratase.","GO:0001666|response to hypoxia;GO:0006782|protoporphyrinogen IX biosynthetic process;GO:0006783|heme biosynthetic process;GO:0006979|response to oxidative stress;GO:0007584|response to nutrient;GO:0009410|response to xenobiotic stimulus;GO:0009635|response to herbicide;GO:0009636|response to toxic substance;GO:0009725|response to hormone;GO:0010033|response to organic substance;GO:0010035|response to inorganic substance;GO:0010038|response to metal ion;GO:0010039|response to iron ion;GO:0010043|response to zinc ion;GO:0010044|response to aluminum ion;GO:0010212|response to ionizing radiation;GO:0010266|response to vitamin B1;GO:0010269|response to selenium ion;GO:0010288|response to lead ion;GO:0014070|response to organic cyclic compound;GO:0014823|response to activity;GO:0031667|response to nutrient levels;GO:0032025|response to cobalt ion;GO:0032496|response to lipopolysaccharide;GO:0033197|response to vitamin E;GO:0033273|response to vitamin;GO:0043200|response to amino acid;GO:0045471|response to ethanol;GO:0046685|response to arsenic-containing substance;GO:0046686|response to cadmium ion;GO:0046689|response to mercury ion;GO:0051260|protein homooligomerization;GO:0051384|response to glucocorticoid;GO:0051597|response to methylmercury;GO:0070541|response to platinum ion;GO:0070542|response to fatty acid;GO:0071284|cellular response to lead ion;GO:0071353|cellular response to interleukin-4;GO:1901799|negative regulation of proteasomal protein catabolic process;","GO:0005615|extracellular space;GO:0005829|cytosol;","GO:0004655|porphobilinogen synthase activity;GO:0008270|zinc ion binding;GO:0042802|identical protein binding;GO:1904854|proteasome core complex binding;","K01698","hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]"]
["ENSRNOG00000006037",174,11.19349624,4,0.258247439,43.3440746,5.437762876,{"v":1.17509E-42,"d":"1.18E-42"},{"v":3.32901e-42,"d":"3.33E-42"},"up","yes","Snap25","protein_coding","chr3:124041898-124123760:+","gi|537150988|gb|ERE71496.1|",1122,{"v":4e-146,"d":"4.00E-146"},"synaptosomal-associated protein 25 [Cricetulus griseus]","gi|396080313|ref|NM_001270575.1|",2103,0,"Rattus norvegicus synaptosomal-associated protein 25 (Snap25), transcript variant 1, mRNA","P60881",398,{"v":3e-133,"d":"3.00E-133"},"Synaptosomal-associated protein 25",".",".",".",".","pfam05739","SNARE","SNARE domain. Most if not all vesicular membrane fusion events in eukaryotic cells are believed to be mediated by a conserved fusion machinery, the SNARE [soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) receptors] machinery. The SNARE domain is thought to act as a protein-protein interaction module in the assembly of a SNARE protein complex.",".",".",".",".","."]
["ENSRNOG00000010580",896,57.64007261,406,26.21211502,2.198985949,1.136838386,{"v":1.25802E-42,"d":"1.26E-42"},{"v":3.56042e-42,"d":"3.56E-42"},"up","yes","Acot7","protein_coding","chr5:162684645-162779309:+","gi|225690614|ref|NP_579926.2|",1933,0,"cytosolic acyl coenzyme A thioester hydrolase isoform 2 [Mus musculus]","gi|225690625|ref|NM_013214.4|",1430,0,"Rattus norvegicus acyl-CoA thioesterase 7 (Acot7), transcript variant 2, mRNA","Q64559",675,0,"Cytosolic acyl coenzyme A thioester hydrolase","BH2302",112,{"v":1E-26,"d":"1.00E-26"},"COG1607","pfam03061","4HBT","Thioesterase superfamily. This family contains a wide variety of enzymes, principally thioesterases. This family includes 4HBT (EC 3.1.2.23) which catalyses the final step in the biosynthesis of 4-hydroxybenzoate from 4-chlorobenzoate in the soil dwelling microbe Pseudomonas CBS-3. This family includes various cytosolic long-chain acyl-CoA thioester hydrolases. Long-chain acyl-CoA hydrolases hydrolyse palmitoyl-CoA to CoA and palmitate, they also catalyse the hydrolysis of other long chain fatty acyl-CoA thioesters.","GO:0006631|fatty acid metabolic process;GO:0006637|acyl-CoA metabolic process;GO:0009062|fatty acid catabolic process;GO:0015937|coenzyme A biosynthetic process;GO:0036114|medium-chain fatty-acyl-CoA catabolic process;GO:0036116|long-chain fatty-acyl-CoA catabolic process;GO:0051792|medium-chain fatty acid biosynthetic process;GO:1900535|palmitic acid biosynthetic process;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005759|mitochondrial matrix;GO:0005829|cytosol;GO:0043005|neuron projection;GO:0044297|cell body;","GO:0000062|fatty-acyl-CoA binding;GO:0016290|palmitoyl-CoA hydrolase activity;GO:0016790|thiolester hydrolase activity;GO:0036042|long-chain fatty acyl-CoA binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0047617|acyl-CoA hydrolase activity;GO:0052689|carboxylic ester hydrolase activity;GO:0102991|myristoyl-CoA hydrolase activity;","K17360","ACOT7; acyl-coenzyme A thioesterase 7 [EC:3.1.2.2]"]
["ENSRNOG00000015397",740,47.60452426,303,19.56224348,2.433490019,1.283026858,{"v":1.26059E-42,"d":"1.26E-42"},{"v":3.56594e-42,"d":"3.57E-42"},"up","yes","Cpne7","protein_coding","chr19:51166034-51182677:+","gi|564396208|ref|XP_006255836.1|",2923,0,"PREDICTED: copine-7 isoform X1 [Rattus norvegicus]","gi|672085289|ref|XM_006255774.2|",2421,0,"PREDICTED: Rattus norvegicus copine VII (Cpne7), transcript variant X1, mRNA","H1UBN0",1130,0,"Copine-7",".",".",".",".","pfam07002","Copine","Copine. This family represents a conserved region approximately 180 residues long within eukaryotic copines. Copines are Ca(2+)-dependent phospholipid-binding proteins that are thought to be involved in membrane-trafficking, and may also be involved in cell division and growth.","GO:0071277|cellular response to calcium ion;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;","GO:0005544|calcium-dependent phospholipid binding;GO:0046872|metal ion binding;","K24525","CPNE4_6_7; copine 4/6/7"]
["ENSRNOG00000024808",991,63.75146424,471,30.4086359,2.096492077,1.067977378,{"v":1.29701E-42,"d":"1.30E-42"},{"v":3.66713e-42,"d":"3.67E-42"},"up","yes","Stk39","protein_coding","chr3:52913585-53179060:-","gi|148695071|gb|EDL27018.1|",2698,0,"serine/threonine kinase 39, STE20/SPS1 homolog (yeast), isoform CRA_a, partial [Mus musculus]","gi|9507132|ref|NM_019362.1|",3548,0,"Rattus norvegicus serine threonine kinase 39 (Stk39), mRNA","O88506",1035,0,"STE20/SPS1-related proline-alanine-rich protein kinase",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0001933|negative regulation of protein phosphorylation;GO:0006468|protein phosphorylation;GO:0007165|signal transduction;GO:0008217|regulation of blood pressure;GO:0010820|positive regulation of T cell chemotaxis;GO:0018105|peptidyl-serine phosphorylation;GO:0018107|peptidyl-threonine phosphorylation;GO:0032414|positive regulation of ion transmembrane transporter activity;GO:0035556|intracellular signal transduction;GO:0036438|maintenance of lens transparency;GO:0038146|chemokine (C-X-C motif) ligand 12 signaling pathway;GO:0043268|positive regulation of potassium ion transport;GO:0046777|protein autophosphorylation;GO:0050727|regulation of inflammatory response;GO:0050801|ion homeostasis;GO:0071476|cellular hypotonic response;GO:0090188|negative regulation of pancreatic juice secretion;GO:1900745|positive regulation of p38MAPK cascade;GO:1901017|negative regulation of potassium ion transmembrane transporter activity;GO:1901380|negative regulation of potassium ion transmembrane transport;GO:1905408|negative regulation of creatine transmembrane transporter activity;GO:1990869|cellular response to chemokine;GO:2000650|negative regulation of sodium ion transmembrane transporter activity;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0016020|membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0019898|extrinsic component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0016301|kinase activity;GO:0019901|protein kinase binding;","K08835","OXSR1, STK39; serine/threonine-protein kinase OSR1/STK39 [EC:2.7.11.1]"]
["ENSRNOG00000011944",950,61.11391628,443,28.60090383,2.136782692,1.095440195,{"v":1.424e-42,"d":"1.42E-42"},{"v":4.02419e-42,"d":"4.02E-42"},"up","yes","Snx10","protein_coding","chr4:80612669-80676996:+","gi|61556910|ref|NP_001013103.1|",798,{"v":6e-96,"d":"6.00E-96"},"sorting nexin-10 [Rattus norvegicus]","gi|672049519|ref|XM_006236488.2|",1405,0,"PREDICTED: Rattus norvegicus sorting nexin 10 (Snx10), transcript variant X4, mRNA","Q9CWT3",310,{"v":9e-97,"d":"9.00E-97"},"Sorting nexin-10","SPBC887.06c",52.4,7e-07,"COG5391","pfam00787","PX","PX domain. PX domains bind to phosphoinositides.","GO:0001696|gastric acid secretion;GO:0006886|intracellular protein transport;GO:0006897|endocytosis;GO:0007032|endosome organization;GO:0030316|osteoclast differentiation;GO:0035630|bone mineralization involved in bone maturation;GO:0044691|tooth eruption;GO:0045453|bone resorption;GO:0046849|bone remodeling;GO:0055074|calcium ion homeostasis;GO:0060271|cilium assembly;GO:0061512|protein localization to cilium;GO:0071539|protein localization to centrosome;GO:0097178|ruffle assembly;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0005634|nucleus;GO:0005783|endoplasmic reticulum;GO:0005813|centrosome;GO:0030141|secretory granule;GO:0031313|extrinsic component of endosome membrane;GO:0090651|apical cytoplasm;","GO:0005545|1-phosphatidylinositol binding;GO:0051117|ATPase binding;","K17924","SNX10_11; sorting nexin-10/11"]
["ENSRNOG00000016148",501,32.22954953,158,10.20077383,3.15952006,1.659705426,{"v":2.16593e-42,"d":"2.17E-42"},{"v":6.09375e-42,"d":"6.09E-42"},"up","yes","Gtse1","protein_coding","chr7:116950053-116966806:+","gi|194473654|ref|NP_001123972.1|",3045,0,"G2 and S phase-expressed protein 1 [Rattus norvegicus]","gi|672059892|ref|XM_006242160.2|",2698,0,"PREDICTED: Rattus norvegicus G-2 and S-phase expressed 1 (Gtse1), transcript variant X1, mRNA","Q8R080",914,0,"G2 and S phase-expressed protein 1",".",".",".",".","pfam15259","GTSE1_N","G-2 and S-phase expressed 1. This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S phase-expressed-1) protein is specifically expressed during S and G2 phases of the cell cycle. It is mainly localized to the microtubules and when overexpressed delays the G2 to M transition. the full protein negatively regulates p53 transactivation function, protein levels, and p53-dependent apoptosis. This domain family is found in eukaryotes, and is approximately 140 amino acids in length. There is a conserved FDFD sequence motif.",".","GO:0005881|cytoplasmic microtubule;GO:0015630|microtubule cytoskeleton;","GO:0008017|microtubule binding;","K10129","GTSE1, B99; G-2 and S-phase expressed protein 1"]
["ENSRNOG00000007886",180,11.57947887,8,0.516494877,22.41934893,4.486672477,{"v":8.31259e-42,"d":"8.31E-42"},{"v":2.32269E-41,"d":"2.32E-41"},"up","yes","Orm1","protein_coding","chr5:76772941-76776154:+","gi|16757980|ref|NP_445740.1|",528,{"v":2e-62,"d":"2.00E-62"},"alpha-1-acid glycoprotein precursor [Rattus norvegicus]","gi|298906865|emb|FQ228584.1|",478,0,"Rattus norvegicus TL0ADA6YH24 mRNA sequence","P02764",207,{"v":5e-64,"d":"5.00E-64"},"Alpha-1-acid glycoprotein",".",".",".",".","pfam00061","Lipocalin","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.","GO:0002438|acute inflammatory response to antigenic stimulus;GO:0002439|chronic inflammatory response to antigenic stimulus;GO:0002682|regulation of immune system process;GO:0006953|acute-phase response;GO:0009410|response to xenobiotic stimulus;GO:0014070|response to organic cyclic compound;GO:0031100|animal organ regeneration;GO:0032496|response to lipopolysaccharide;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032732|positive regulation of interleukin-1 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0033197|response to vitamin E;GO:0071300|cellular response to retinoic acid;GO:0071378|cellular response to growth hormone stimulus;GO:0071385|cellular response to glucocorticoid stimulus;","GO:0005615|extracellular space;","GO:0036094|small molecule binding;","K17308","ORM, AGP; alpha-1-acid glycoprotein"]
["ENSRNOG00000063664",952,61.24257715,449,28.98827499,2.11266718,1.079065509,{"v":1.13662E-41,"d":"1.14E-41"},{"v":3.16819e-41,"d":"3.17E-41"},"up","yes","Timm17b","protein_coding","chrX:14594577-14603416:-","gi|593764807|ref|XP_007120974.1|",865,{"v":2e-108,"d":"2.00E-108"},"PREDICTED: mitochondrial import inner membrane translocase subunit Tim17-B isoform X1 [Physeter catodon]","gi|564398764|ref|XM_003752008.2|",483,0,"PREDICTED: Rattus norvegicus mitochondrial import inner membrane translocase subunit Tim17-B-like (LOC100911130), mRNA","Q9Z0V7",330,{"v":6e-108,"d":"6.00E-108"},"Mitochondrial import inner membrane translocase subunit Tim17-B","YJL143w",130,{"v":5e-34,"d":"5.00E-34"},"COG5596","pfam02466","Tim17","Tim17/Tim22/Tim23/Pmp24 family. The pre-protein translocase of the mitochondrial outer membrane (Tom) allows the import of pre-proteins from the cytoplasm. Tom forms a complex with a number of proteins, including Tim17. Tim17 and Tim23 are thought to form the translocation channel of the inner membrane. This family includes Tim17, Tim22 and Tim23. This family also includes Pmp24 a peroxisomal protein. The involvement of this domain in the targeting of PMP24 remains to be proved. PMP24 was known as Pmp27 in.",".",".",".",".","."]
["ENSRNOG00000011068",950,61.11391628,449,28.98827499,2.108228803,1.076031449,{"v":2.09686E-41,"d":"2.10E-41"},{"v":5.81631e-41,"d":"5.82E-41"},"up","yes","Papss2","protein_coding","chr1:230454426-230539331:+","gi|564333456|ref|XP_006231336.1|",3267,0,"PREDICTED: bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1 [Rattus norvegicus]","gi|672040070|ref|XM_006231274.2|",3500,0,"PREDICTED: Rattus norvegicus 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (Papss2), transcript variant X1, mRNA","O88428",1220,0,"Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2","SPAC1782.11",214,{"v":6e-62,"d":"6.00E-62"},"COG0529","pfam01583","APS_kinase","Adenylylsulphate kinase. Enzyme that catalyses the phosphorylation of adenylylsulphate to 3'-phosphoadenylylsulfate. This domain contains an ATP binding P-loop motif.","GO:0000103|sulfate assimilation;GO:0007596|blood coagulation;GO:0008150|biological_process;GO:0016310|phosphorylation;GO:0050428|3'-phosphoadenosine 5'-phosphosulfate biosynthetic process;GO:0060348|bone development;","GO:0005575|cellular_component;GO:0005829|cytosol;","GO:0003674|molecular_function;GO:0004020|adenylylsulfate kinase activity;GO:0004781|sulfate adenylyltransferase (ATP) activity;GO:0005524|ATP binding;GO:0098616|selenate adenylyltransferase (ATP) activity;","K13811","PAPSS; 3'-phosphoadenosine 5'-phosphosulfate synthase [EC:2.7.7.4 2.7.1.25]"]
["ENSRNOG00000016403",449,28.88436674,132,8.522165474,3.389322448,1.760996896,{"v":2.43884e-41,"d":"2.44E-41"},{"v":6.75509e-41,"d":"6.76E-41"},"up","yes","Olah","protein_coding","chr17:74877655-74902518:+","gi|12083671|ref|NP_073196.1|",1365,0,"S-acyl fatty acid synthase thioesterase, medium chain [Rattus norvegicus]","gi|672082480|ref|XM_008771886.1|",1385,0,"PREDICTED: Rattus norvegicus oleoyl-ACP hydrolase (Olah), transcript variant X1, mRNA","P08635",530,0,"S-acyl fatty acid synthase thioesterase, medium chain","alr2045",145,{"v":5e-39,"d":"5.00E-39"},"COG3208","pfam00975","Thioesterase","Thioesterase domain. Peptide synthetases are involved in the non-ribosomal synthesis of peptide antibiotics. Next to the operons encoding these enzymes, in almost all cases, are genes that encode proteins that have similarity to the type II fatty acid thioesterases of vertebrates. There are also modules within the peptide synthetases that also share this similarity. With respect to antibiotic production, thioesterases are required for the addition of the last amino acid to the peptide antibiotic, thereby forming a cyclic antibiotic. Thioesterases (non-integrated) have molecular masses of 25-29 kDa.","GO:0008610|lipid biosynthetic process;GO:0051792|medium-chain fatty acid biosynthetic process;","GO:0005829|cytosol;","GO:0004320|oleoyl-[acyl-carrier-protein] hydrolase activity;GO:0016290|palmitoyl-CoA hydrolase activity;GO:0016295|myristoyl-[acyl-carrier-protein] hydrolase activity;GO:0016296|palmitoyl-[acyl-carrier-protein] hydrolase activity;GO:0016297|acyl-[acyl-carrier-protein] hydrolase activity;GO:0047381|dodecanoyl-[acyl-carrier-protein] hydrolase activity;GO:0102991|myristoyl-CoA hydrolase activity;","K01071","MCH; medium-chain acyl-[acyl-carrier-protein] hydrolase [EC:3.1.2.21]"]
["ENSRNOG00000014336",748,48.11916776,315,20.33698579,2.366091428,1.242505822,{"v":4.78056e-41,"d":"4.78E-41"},{"v":1.31646e-40,"d":"1.32E-40"},"up","yes","Mcm5","protein_coding","chr19:13483066-13504389:+","gi|183986534|gb|AAI66442.1|",3713,0,"Mcm5 protein [Rattus norvegicus]","gi|672084082|ref|XM_008772283.1|",2921,0,"PREDICTED: Rattus norvegicus minichromosome maintenance complex component 5 (Mcm5), transcript variant X1, mRNA","P49718",1401,0,"DNA replication licensing factor MCM5","YLR274w",612,0,"COG1241","pfam00493","MCM","MCM2/3/5 family.","GO:0000727|double-strand break repair via break-induced replication;GO:0006270|DNA replication initiation;GO:0032508|DNA duplex unwinding;GO:0051301|cell division;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005694|chromosome;GO:0042555|MCM complex;","GO:0003688|DNA replication origin binding;GO:0003697|single-stranded DNA binding;GO:0005524|ATP binding;GO:0017116|single-stranded DNA-dependent ATP-dependent DNA helicase activity;GO:0043138|3'-5' DNA helicase activity;","K02209","MCM5, CDC46; DNA replication licensing factor MCM5 [EC:5.6.2.3]"]
["ENSRNOG00000022934",638,41.04281956,245,15.81765562,2.594747323,1.375594055,{"v":5.56712e-41,"d":"5.57E-41"},{"v":1.53084e-40,"d":"1.53E-40"},"up","yes","AABR07066818.1","protein_coding","chr9:14826695-14827663:-","gi|2920833|gb|AAC04625.1|",1272,{"v":9E-175,"d":"9.00E-175"},"ribosomal protein S2 [Rattus norvegicus]","gi|309951072|ref|NG_027835.1|",802,0,"Rattus norvegicus ribosomal protein S2, pseudogene 6 (Rps2-ps6) on chromosome 9","P27952",493,{"v":3E-175,"d":"3.00E-175"},"40S ribosomal protein S2","SPCC576.08c",329,{"v":1e-111,"d":"1.00E-111"},"COG0098","pfam00333","Ribosomal_S5","Ribosomal protein S5, N-terminal domain.",".",".",".",".","."]
["ENSRNOG00000032699",410,26.37547966,112,7.230928281,3.647592485,1.866944558,{"v":6.45959e-41,"d":"6.46E-41"},{"v":1.77454E-40,"d":"1.77E-40"},"up","yes","Ttyh1","protein_coding","chr1:70053324-70071845:-","gi|157819361|ref|NP_001099695.1|",1592,0,"protein tweety homolog 1 [Rattus norvegicus]","gi|672034966|ref|XM_006228216.2|",3076,0,"PREDICTED: Rattus norvegicus tweety family member 1 (Ttyh1), transcript variant X1, mRNA","P0C5X8",617,0,"Protein tweety homolog 1",".",".",".",".","pfam04906","Tweety","Tweety. The tweety (tty) gene has not been characterized at the protein level. However, it is thought to form a membrane protein with five potential membrane-spanning regions. A number of potential functions have been suggested in.","GO:0000278|mitotic cell cycle;GO:0006821|chloride transport;GO:0031589|cell-substrate adhesion;GO:0046847|filopodium assembly;GO:0098609|cell-cell adhesion;","GO:0005886|plasma membrane;GO:0030868|smooth endoplasmic reticulum membrane;GO:0031527|filopodium membrane;GO:0032433|filopodium tip;GO:0034707|chloride channel complex;GO:0045202|synapse;","GO:0005229|intracellular calcium activated chloride channel activity;GO:0005509|calcium ion binding;GO:0072320|volume-sensitive chloride channel activity;","K22641","TTYH; protein tweety"]
["ENSRNOG00000047653",188,12.09412238,12,0.774742316,15.61050963,3.964445732,{"v":6.78115e-41,"d":"6.78E-41"},{"v":1.86198e-40,"d":"1.86E-40"},"up","yes","Crybb1","protein_coding","chr12:44369735-44383344:-","gi|568935244|ref|XP_006534815.1|",1039,{"v":3e-137,"d":"3.00E-137"},"PREDICTED: beta-crystallin B1 isoform X2 [Mus musculus]","gi|162287072|ref|NM_012936.2|",979,0,"Rattus norvegicus crystallin, beta B1 (Crybb1), mRNA","Q9WVJ5",391,{"v":3e-135,"d":"3.00E-135"},"Beta-crystallin B1",".",".",".",".","pfam00030","Crystall","Beta/Gamma crystallin. The alignment comprises two Greek key motifs since the similarity between them is very low.","GO:0002088|lens development in camera-type eye;GO:0007601|visual perception;",".","GO:0005212|structural constituent of eye lens;","K23482","CRYB; beta-crystallin"]
["ENSRNOG00000010816",182,11.70813975,10,0.645618597,18.13476225,4.180685926,{"v":7.52845e-41,"d":"7.53E-41"},{"v":2.06618e-40,"d":"2.07E-40"},"up","yes","Kcnk15","protein_coding","chr3:152515237-152521455:+","gi|39930507|ref|NP_570826.1|",1460,0,"potassium channel subfamily K member 15 [Rattus norvegicus]","gi|39930506|ref|NM_130813.1|",2385,0,"Rattus norvegicus potassium two pore domain channel subfamily K member 15 (Kcnk15), mRNA","Q8R5I0",566,0,"Potassium channel subfamily K member 15",".",".",".",".","pfam07885","Ion_trans_2","Ion channel. This family includes the two membrane helix type ion channels found in bacteria.","GO:0030322|stabilization of membrane potential;GO:0034765|regulation of ion transmembrane transport;GO:0071805|potassium ion transmembrane transport;","GO:0005887|integral component of plasma membrane;","GO:0022841|potassium ion leak channel activity;","K04923","KCNK15, K2P15.1; potassium channel subfamily K member 15"]
["ENSRNOG00000001517",544,34.99575837,189,12.20219147,2.86798961,1.520039798,{"v":1.33817E-40,"d":"1.34E-40"},{"v":3.6568e-40,"d":"3.66E-40"},"up","yes","Pdk1","protein_coding","chr3:56705871-56733038:+","gi|59709473|ref|NP_446278.2|",2153,0,"pyruvate dehydrogenase kinase, isozyme 1 precursor [Rattus norvegicus]","gi|59709472|ref|NM_053826.2|",1579,0,"Rattus norvegicus pyruvate dehydrogenase kinase 1 (Pdk1), mRNA","Q63065",832,0,"[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial","SPAC644.11c",196,{"v":1e-55,"d":"1.00E-55"},"COG0642","pfam10436","BCDHK_Adom3","Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase. Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal.","GO:0006006|glucose metabolic process;GO:0006468|protein phosphorylation;GO:0007166|cell surface receptor signaling pathway;GO:0008283|cell proliferation;GO:0008631|intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0010510|regulation of acetyl-CoA biosynthetic process from pyruvate;GO:0010906|regulation of glucose metabolic process;GO:0018105|peptidyl-serine phosphorylation;GO:0097411|hypoxia-inducible factor-1alpha signaling pathway;","GO:0005739|mitochondrion;GO:0005967|mitochondrial pyruvate dehydrogenase complex;GO:0045254|pyruvate dehydrogenase complex;","GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0004740|pyruvate dehydrogenase (acetyl-transferring) kinase activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;","K12077","PDK1; pyruvate dehydrogenase kinase isoform 1 [EC:2.7.11.2]"]
["ENSRNOG00000008137",570,36.66834977,205,13.23518123,2.770521169,1.47015739,{"v":1.71213e-40,"d":"1.71E-40"},{"v":4.66977e-40,"d":"4.67E-40"},"up","yes","Cdk18","protein_coding","chr13:43556748-43588525:-","gi|564380463|ref|XP_006249812.1|",2431,0,"PREDICTED: cyclin-dependent kinase 18 isoform X2 [Rattus norvegicus]","gi|672073681|ref|XM_008769441.1|",1506,0,"PREDICTED: Rattus norvegicus cyclin-dependent kinase 18 (Cdk18), transcript variant X5, mRNA","O35832",927,0,"Cyclin-dependent kinase 18",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0000083|regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0006468|protein phosphorylation;GO:0051726|regulation of cell cycle;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0004674|protein serine/threonine kinase activity;GO:0004693|cyclin-dependent protein serine/threonine kinase activity;GO:0005524|ATP binding;","K15596","CDK18, PCTK3; cyclin-dependent kinase 18 [EC:2.7.11.22]"]
["ENSRNOG00000054391",707,45.4816198,292,18.85206302,2.412553987,1.270561227,{"v":3.26079e-40,"d":"3.26E-40"},{"v":8.84721e-40,"d":"8.85E-40"},"up","yes","Snrpn","protein_coding","chr1:111101329-111123634:-","gi|675690021|ref|XP_009004277.1|",621,{"v":6e-74,"d":"6.00E-74"},"PREDICTED: small nuclear ribonucleoprotein-associated protein N isoform X2 [Callithrix jacchus]","gi|397787562|ref|NM_001270712.1|",1467,0,"Rattus norvegicus SNRPN upstream reading frame (Snurf), transcript variant 1, mRNA","P63164",238,{"v":4E-73,"d":"4.00E-73"},"Small nuclear ribonucleoprotein-associated protein N","SPAC26A3.08",98.6,{"v":4e-23,"d":"4.00E-23"},"COG1958","pfam07192","SNURF","SNURF/RPN4 protein. This family consists of several mammalian SNRPN upstream reading frame (SNURF) proteins. SNURF or RPF4 is a RING-finger protein and a coregulator of androgen receptor-dependent transcription. It has been suggested that SNURF is involved in the regulation of processes required for late steps of spermatid maturation.",".","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0016607|nuclear speck;","GO:0051117|ATPase binding;",".","."]
["ENSRNOG00000000275",863,55.51716815,396,25.56649642,2.171481271,1.11867951,{"v":4.10023e-40,"d":"4.10E-40"},{"v":1.1109E-39,"d":"1.11E-39"},"up","yes","Fam13c","protein_coding","chr20:18065628-18187592:-","gi|564322029|ref|XP_006223927.1|",2743,0,"PREDICTED: protein FAM13C isoform X2 [Rattus norvegicus]","gi|672031658|ref|XM_001080212.5|",3187,0,"PREDICTED: Rattus norvegicus family with sequence similarity 13, member C (Fam13c), transcript variant X4, mRNA",".",".",".",".",".",".",".",".","pfam05110","AF-4","AF-4 proto-oncoprotein. This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.",".",".",".",".","."]
["ENSRNOG00000018358",737,47.41153294,312,20.14330021,2.353712274,1.234937971,{"v":4.24104e-40,"d":"4.24E-40"},{"v":1.1485e-39,"d":"1.15E-39"},"up","yes","Nt5dc2","protein_coding","chr16:6322236-6330537:+","gi|149034194|gb|EDL88964.1|",2675,0,"rCG42310 [Rattus norvegicus]","gi|57164144|ref|NM_001009271.1|",1797,0,"Rattus norvegicus 5'-nucleotidase domain containing 2 (Nt5dc2), mRNA","Q6Q0N3",1025,0,"5'-nucleotidase domain-containing protein 2",".",".",".",".","pfam05761","5_nucleotid","5' nucleotidase family. This family of eukaryotic proteins includes 5' nucleotidase enzymes, such as purine 5'-nucleotidase EC:3.1.3.5.","GO:0016311|dephosphorylation;",".","GO:0008253|5'-nucleotidase activity;GO:0046872|metal ion binding;",".","."]
["ENSRNOG00000046171",415,26.69713185,117,7.55373758,3.534294323,1.821422187,{"v":4.39054e-40,"d":"4.39E-40"},{"v":1.18842e-39,"d":"1.19E-39"},"up","yes","AABR07035839.1","protein_coding","chr12:21543576-21577112:-","gi|254826556|emb|CBA11522.1|",3589,0,"carbohydrate response element binding protein [Rattus norvegicus]","gi|19424225|ref|NM_133552.1|",3145,0,"Rattus norvegicus MLX interacting protein-like (Mlxipl), mRNA","Q8VIP2",1379,0,"Carbohydrate-responsive element-binding protein",".",".",".",".","pfam00010","HLH","Helix-loop-helix DNA-binding domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006110|regulation of glycolytic process;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008284|positive regulation of cell proliferation;GO:0009749|response to glucose;GO:0010255|glucose mediated signaling pathway;GO:0033137|negative regulation of peptidyl-serine phosphorylation;GO:0042593|glucose homeostasis;GO:0045723|positive regulation of fatty acid biosynthetic process;GO:0045821|positive regulation of glycolytic process;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046889|positive regulation of lipid biosynthetic process;GO:0051726|regulation of cell cycle;GO:0055089|fatty acid homeostasis;GO:0071333|cellular response to glucose stimulus;GO:0090324|negative regulation of oxidative phosphorylation;GO:0097009|energy homeostasis;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0005515|protein binding;GO:0019901|protein kinase binding;GO:0035538|carbohydrate response element binding;GO:0043565|sequence-specific DNA binding;GO:0046982|protein heterodimerization activity;","K09113","MLX; MAX-like protein X"]
["ENSRNOG00000004307",390,25.08887089,104,6.714433404,3.736558155,1.901709976,{"v":6.07647e-40,"d":"6.08E-40"},{"v":1.63778E-39,"d":"1.64E-39"},"up","yes","Tor3a","protein_coding","chr13:68769605-68798475:-","gi|57527353|ref|NP_001009683.1|",1901,0,"torsin-3A precursor [Rattus norvegicus]","gi|57527352|ref|NM_001009683.1|",1809,0,"Rattus norvegicus torsin family 3, member A (Tor3a), mRNA","Q5M936",736,0,"Torsin-3A",".",".",".",".","pfam06309","Torsin","Torsin. This family consists of several eukaryotic torsin proteins. Torsion dystonia is an autosomal dominant movement disorder characterized by involuntary, repetitive muscle contractions and twisted postures. The most severe early-onset form of dystonia has been linked to mutations in the human DYT1 (TOR1A) gene encoding a protein termed torsinA. While causative genetic alterations have been identified, the function of torsin proteins and the molecular mechanism underlying dystonia remain unknown. Phylogenetic analysis of the torsin protein family indicates these proteins share distant sequence similarity with the large and diverse family of (pfam00004) proteins. It has been suggested that torsins play a role in effectively managing protein folding and that possible breakdown in a neuroprotective mechanism that is, in part, mediated by torsins may be responsible for the neuronal dysfunction associated with dystonia.",".","GO:0005635|nuclear envelope;GO:0005783|endoplasmic reticulum;GO:0005788|endoplasmic reticulum lumen;","GO:0005524|ATP binding;","K23000","TOR3A, ADIR; torsin-3A"]
["ENSRNOG00000049770",292,18.78448795,56,3.615464141,5.195595149,2.377289017,{"v":1.20438E-39,"d":"1.20E-39"},{"v":3.22939e-39,"d":"3.23E-39"},"up","yes","Cryba4","protein_coding","chr12:44378737-44393221:+","gi|568935238|ref|XP_006534812.1|",1050,{"v":3e-141,"d":"3.00E-141"},"PREDICTED: beta-crystallin A4 isoform X1 [Mus musculus]","gi|13928955|ref|NM_031689.1|",774,0,"Rattus norvegicus crystallin, beta A4 (Cryba4), mRNA","P56374",407,{"v":2e-142,"d":"2.00E-142"},"Beta-crystallin A4",".",".",".",".","pfam00030","Crystall","Beta/Gamma crystallin. The alignment comprises two Greek key motifs since the similarity between them is very low.","GO:0002088|lens development in camera-type eye;GO:0007601|visual perception;GO:0008150|biological_process;GO:0043010|camera-type eye development;","GO:0005575|cellular_component;","GO:0005212|structural constituent of eye lens;GO:0042802|identical protein binding;","K23482","CRYB; beta-crystallin"]
["ENSRNOG00000042536",408,26.24681878,116,7.48917572,3.504633856,1.809263727,{"v":4.30563E-39,"d":"4.31E-39"},{"v":1.14216E-38,"d":"1.14E-38"},"up","yes","Pde4d","protein_coding","chr2:40019933-41525884:+","gi|568984459|ref|XP_006517708.1|",3690,0,"PREDICTED: cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X3 [Mus musculus]","gi|880862234|ref|XM_005065552.2|",2896,0,"PREDICTED: Mesocricetus auratus phosphodiesterase 4D, cAMP-specific (Pde4d), transcript variant X4, mRNA","P14270",1331,0,"cAMP-specific 3',5'-cyclic phosphodiesterase 4D",".",".",".",".","pfam00233","PDEase_I","3'5'-cyclic nucleotide phosphodiesterase.","GO:0001934|positive regulation of protein phosphorylation;GO:0002027|regulation of heart rate;GO:0006198|cAMP catabolic process;GO:0006939|smooth muscle contraction;GO:0007165|signal transduction;GO:0007568|aging;GO:0007613|memory;GO:0008277|regulation of G protein-coupled receptor signaling pathway;GO:0010469|regulation of signaling receptor activity;GO:0010880|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0014911|positive regulation of smooth muscle cell migration;GO:0022409|positive regulation of cell-cell adhesion;GO:0030324|lung development;GO:0030593|neutrophil chemotaxis;GO:0032729|positive regulation of interferon-gamma production;GO:0032743|positive regulation of interleukin-2 production;GO:0032754|positive regulation of interleukin-5 production;GO:0033137|negative regulation of peptidyl-serine phosphorylation;GO:0034622|cellular protein-containing complex assembly;GO:0035264|multicellular organism growth;GO:0043949|regulation of cAMP-mediated signaling;GO:0043951|negative regulation of cAMP-mediated signaling;GO:0045822|negative regulation of heart contraction;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0050852|T cell receptor signaling pathway;GO:0050900|leukocyte migration;GO:0060314|regulation of ryanodine-sensitive calcium-release channel activity;GO:0061028|establishment of endothelial barrier;GO:0071222|cellular response to lipopolysaccharide;GO:0071320|cellular response to cAMP;GO:0071872|cellular response to epinephrine stimulus;GO:0071875|adrenergic receptor signaling pathway;GO:0086004|regulation of cardiac muscle cell contraction;GO:0086024|adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate;GO:1901898|negative regulation of relaxation of cardiac muscle;","GO:0005634|nucleus;GO:0005794|Golgi apparatus;GO:0005813|centrosome;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005891|voltage-gated calcium channel complex;GO:0016020|membrane;GO:0016324|apical plasma membrane;GO:0030016|myofibril;GO:0032991|protein-containing complex;GO:0034704|calcium channel complex;GO:0034705|potassium channel complex;GO:0048471|perinuclear region of cytoplasm;","GO:0004112|cyclic-nucleotide phosphodiesterase activity;GO:0004114|3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0004115|3',5'-cyclic-AMP phosphodiesterase activity;GO:0005515|protein binding;GO:0019899|enzyme binding;GO:0030552|cAMP binding;GO:0031698|beta-2 adrenergic receptor binding;GO:0044325|ion channel binding;GO:0046872|metal ion binding;GO:0051117|ATPase binding;GO:0097110|scaffold protein binding;GO:1901363|heterocyclic compound binding;","K13293","PDE4; cAMP-specific phosphodiesterase 4 [EC:3.1.4.53]"]
["ENSRNOG00000048118",800,51.46435055,360,23.24226948,2.214256684,1.146822474,{"v":9.22801e-39,"d":"9.23E-39"},{"v":2.42988e-38,"d":"2.43E-38"},"up","yes","Ankra2","protein_coding","chr2:29612925-29623730:+","gi|46485431|ref|NP_997478.1|",1683,0,"ankyrin repeat family A protein 2 [Rattus norvegicus]","gi|564299675|ref|XM_003753510.2|",1807,0,"PREDICTED: Rattus norvegicus ankyrin repeat family A protein 2-like (LOC100910438), transcript variant X1, mRNA","Q2KI79",639,0,"Ankyrin repeat family A protein 2","all2748",89.4,{"v":3e-18,"d":"3.00E-18"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0010468|regulation of gene expression;GO:0043254|regulation of protein complex assembly;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016020|membrane;GO:0032991|protein-containing complex;","GO:0019901|protein kinase binding;GO:0031625|ubiquitin protein ligase binding;GO:0042826|histone deacetylase binding;GO:0050750|low-density lipoprotein particle receptor binding;","K21486","ANKRA2; ankyrin repeat family A protein 2"]
["ENSRNOG00000055221",202,12.99474851,20,1.291237193,10.06379663,3.331102769,{"v":9.85542e-39,"d":"9.86E-39"},{"v":2.59269e-38,"d":"2.59E-38"},"up","yes","Acot1","protein_coding","chr6:103636041-103644163:+","gi|149025102|gb|EDL81469.1|",2017,0,"rCG20735, isoform CRA_a [Rattus norvegicus]","gi|3445485|dbj|AB010428.1|",1533,0,"Rattus norvegicus mRNA for acyl-CoA hydrolase, complete cds","O88267",780,0,"Acyl-coenzyme A thioesterase 1","CAC3407",144,{"v":8e-37,"d":"8.00E-37"},"COG1073","pfam08840","BAAT_C","BAAT / Acyl-CoA thioester hydrolase C terminal. This catalytic domain is found at the C terminal of acyl-CoA thioester hydrolases and bile acid-CoA:amino acid N-acetyltransferases (BAAT).","GO:0000038|very long-chain fatty acid metabolic process;GO:0001676|long-chain fatty acid metabolic process;GO:0006631|fatty acid metabolic process;GO:0006637|acyl-CoA metabolic process;GO:0010667|negative regulation of cardiac muscle cell apoptotic process;","GO:0005829|cytosol;","GO:0016290|palmitoyl-CoA hydrolase activity;GO:0016790|thiolester hydrolase activity;GO:0047617|acyl-CoA hydrolase activity;GO:0052689|carboxylic ester hydrolase activity;GO:0102991|myristoyl-CoA hydrolase activity;","K01068","ACOT1_2_4; acyl-coenzyme A thioesterase 1/2/4 [EC:3.1.2.2]"]
["ENSRNOG00000067070",334,21.48636635,79,5.100386913,4.212693414,2.074742925,{"v":2.04986e-38,"d":"2.05E-38"},{"v":5.36158e-38,"d":"5.36E-38"},"up","yes","Immp2l","protein_coding","chr6:58070283-58969840:+","gi|594097165|ref|XP_006071827.1|",960,{"v":9e-128,"d":"9.00E-128"},"PREDICTED: mitochondrial inner membrane protease subunit 2-like isoform X1 [Bubalus bubalis]","gi|672020658|ref|XM_006225758.2|",836,0,"PREDICTED: Rattus norvegicus IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) (Immp2l), transcript variant X3, mRNA","Q8BPT6",337,{"v":1e-115,"d":"1.00E-115"},"Mitochondrial inner membrane protease subunit 2","YMR035w",115,{"v":4e-30,"d":"4.00E-30"},"COG0681","pfam00717","Peptidase_S24","Peptidase S24-like.",".",".",".",".","."]
["ENSRNOG00000007489",945,60.79226408,462,29.82757916,2.03812263,1.027240858,{"v":2.59803e-38,"d":"2.60E-38"},{"v":6.78161e-38,"d":"6.78E-38"},"up","yes","Zfp41","protein_coding","chr7:107306867-107320270:+","gi|672022018|ref|XP_008774719.1|",748,{"v":2e-86,"d":"2.00E-86"},"PREDICTED: zinc finger protein 41 homolog [Rattus norvegicus]","gi|672022019|ref|XM_008776498.1|",4430,0,"PREDICTED: Rattus norvegicus uncharacterized LOC100910508 (LOC100910508), transcript variant X2, mRNA","Q02526",288,{"v":2e-86,"d":"2.00E-86"},"Zinc finger protein 41",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;",".","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:1990837|sequence-specific double-stranded DNA binding;",".","."]
["ENSRNOG00000065098",959,61.69289022,472,30.47319776,2.024496763,1.017563336,{"v":2.79556e-38,"d":"2.80E-38"},{"v":7.29055e-38,"d":"7.29E-38"},"up","yes","ENSRNOG00000065098","protein_coding","chr1:222796915-222798193:-","gi|148673911|gb|EDL05858.1|",939,{"v":2e-122,"d":"2.00E-122"},"mCG144566, partial [Mus musculus]","gi|195539711|gb|BC168143.1|",1247,0,"Rattus norvegicus high mobility group box 1, mRNA (cDNA clone MGC:187291 IMAGE:9100911), complete cds","P63159",311,{"v":6E-103,"d":"6.00E-103"},"High mobility group protein B1","YBR089c-a",62.8,{"v":3E-11,"d":"3.00E-11"},"COG5648","pfam09011","HMG_box_2","HMG-box domain. This short 71 residue domain is an HMG-box domain. HMG-box domains mediate re-modelling of chromatin-structure. Mammalian HMG-box proteins are of two types: those that are non-sequence-specific DNA-binding proteins with two HMG-box domains and a long highly acidic C-tail; and a diverse group of sequence-specific transcription factor-proteins with either a single HMG-box or up to six copies, and no acidic C-tail.",".",".",".",".","."]
["ENSRNOG00000016728",678,43.61603709,282,18.20644442,2.395637285,1.260409491,{"v":3.55867e-38,"d":"3.56E-38"},{"v":9.25953e-38,"d":"9.26E-38"},"up","yes","Tiam2","protein_coding","chr1:43918174-44119493:+","gi|564296319|ref|XP_006222963.1|",8575,0,"PREDICTED: T-lymphoma invasion and metastasis-inducing protein 2 isoform X1 [Rattus norvegicus]","gi|672012712|ref|XM_006222901.2|",5714,0,"PREDICTED: Rattus norvegicus T-cell lymphoma invasion and metastasis 2 (LOC100362710), transcript variant X1, mRNA","Q6ZPF3",3048,0,"T-lymphoma invasion and metastasis-inducing protein 2",".",".",".",".","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0007264|small GTPase mediated signal transduction;GO:0050772|positive regulation of axonogenesis;GO:0090630|activation of GTPase activity;","GO:0005737|cytoplasm;GO:0016020|membrane;GO:0045202|synapse;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0005096|GTPase activator activity;","K16847","TIAM2; T-lymphoma invasion and metastasis-inducing protein 2"]
["ENSRNOG00000004479",665,42.77974139,275,17.75451141,2.409513865,1.268742103,{"v":7.59317e-38,"d":"7.59E-38"},{"v":1.95523e-37,"d":"1.96E-37"},"up","yes","Aurka","protein_coding","chr3:161128313-161144390:-","gi|76253851|ref|NP_695208.2|",2051,0,"aurora kinase A [Rattus norvegicus]","gi|672047987|ref|XM_006235676.2|",2307,0,"PREDICTED: Rattus norvegicus aurora kinase A (Aurka), transcript variant X2, mRNA","P59241",792,0,"Aurora kinase A",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0000212|meiotic spindle organization;GO:0000226|microtubule cytoskeleton organization;GO:0000278|mitotic cell cycle;GO:0006468|protein phosphorylation;GO:0007051|spindle organization;GO:0007052|mitotic spindle organization;GO:0007057|spindle assembly involved in female meiosis I;GO:0007098|centrosome cycle;GO:0007100|mitotic centrosome separation;GO:0009611|response to wounding;GO:0009948|anterior/posterior axis specification;GO:0010629|negative regulation of gene expression;GO:0018105|peptidyl-serine phosphorylation;GO:0031647|regulation of protein stability;GO:0032091|negative regulation of protein binding;GO:0032355|response to estradiol;GO:0032436|positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032465|regulation of cytokinesis;GO:0035404|histone-serine phosphorylation;GO:0043066|negative regulation of apoptotic process;GO:0045727|positive regulation of translation;GO:0051301|cell division;GO:0051321|meiotic cell cycle;GO:0051642|centrosome localization;GO:0071539|protein localization to centrosome;GO:0090141|positive regulation of mitochondrial fission;GO:0097421|liver regeneration;GO:1900195|positive regulation of oocyte maturation;GO:1904146|positive regulation of meiotic cell cycle process involved in oocyte maturation;GO:1990138|neuron projection extension;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005813|centrosome;GO:0005814|centriole;GO:0005815|microtubule organizing center;GO:0005819|spindle;GO:0005829|cytosol;GO:0005876|spindle microtubule;GO:0005929|cilium;GO:0015630|microtubule cytoskeleton;GO:0031616|spindle pole centrosome;GO:0032133|chromosome passenger complex;GO:0042585|germinal vesicle;GO:0043203|axon hillock;GO:0045120|pronucleus;GO:0048471|perinuclear region of cytoplasm;GO:0051233|spindle midzone;GO:0072686|mitotic spindle;GO:0072687|meiotic spindle;GO:0097431|mitotic spindle pole;","GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;GO:0019901|protein kinase binding;GO:0031625|ubiquitin protein ligase binding;GO:0035174|histone serine kinase activity;GO:0046982|protein heterodimerization activity;","K11481","AURKA; aurora kinase A [EC:2.7.11.1]"]
["ENSRNOG00000015455",805,51.78600274,368,23.75876435,2.179658924,1.124102398,{"v":8.17711e-38,"d":"8.18E-38"},{"v":2.1018e-37,"d":"2.10E-37"},"up","yes","Spr","protein_coding","chr4:117671949-117675678:-","gi|158711683|ref|NP_062054.1|",1188,{"v":3E-160,"d":"3.00E-160"},"sepiapterin reductase [Rattus norvegicus]","gi|158711682|ref|NM_019181.1|",1195,0,"Rattus norvegicus sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) (Spr), mRNA","P18297",462,{"v":1E-161,"d":"1.00E-161"},"Sepiapterin reductase",".",".",".",".","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.","GO:0006558|L-phenylalanine metabolic process;GO:0006729|tetrahydrobiopterin biosynthetic process;GO:0006809|nitric oxide biosynthetic process;GO:0010033|response to organic substance;GO:0019889|pteridine metabolic process;GO:0040014|regulation of multicellular organism growth;GO:0042415|norepinephrine metabolic process;GO:0042417|dopamine metabolic process;GO:0042428|serotonin metabolic process;GO:0046146|tetrahydrobiopterin metabolic process;GO:0048667|cell morphogenesis involved in neuron differentiation;GO:0050882|voluntary musculoskeletal movement;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004757|sepiapterin reductase activity;GO:0042803|protein homodimerization activity;","K00072","SPR; sepiapterin reductase [EC:1.1.1.153]"]
["ENSRNOG00000007949",201,12.93041808,21,1.355799053,9.537119862,3.253553649,{"v":8.2138e-38,"d":"8.21E-38"},{"v":2.11028e-37,"d":"2.11E-37"},"up","yes","Rgn","protein_coding","chrX:1619032-1634450:-","gi|13928740|ref|NP_113734.1|",1597,0,"regucalcin [Rattus norvegicus]","gi|50927600|gb|BC078794.1|",1591,0,"Rattus norvegicus regucalcin (senescence marker protein-30), mRNA (cDNA clone MGC:93360 IMAGE:7126233), complete cds","Q03336",619,0,"Regucalcin","BS_yvrE",174,{"v":6E-49,"d":"6.00E-49"},"COG3386","pfam08450","SGL","SMP-30/Gluconolaconase/LRE-like region. This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.","GO:0001822|kidney development;GO:0001889|liver development;GO:0001933|negative regulation of protein phosphorylation;GO:0006469|negative regulation of protein kinase activity;GO:0006874|cellular calcium ion homeostasis;GO:0007283|spermatogenesis;GO:0007568|aging;GO:0010867|positive regulation of triglyceride biosynthetic process;GO:0010907|positive regulation of glucose metabolic process;GO:0010922|positive regulation of phosphatase activity;GO:0019853|L-ascorbic acid biosynthetic process;GO:0032515|negative regulation of phosphoprotein phosphatase activity;GO:0032781|positive regulation of ATPase activity;GO:0034260|negative regulation of GTPase activity;GO:0043066|negative regulation of apoptotic process;GO:0043547|positive regulation of GTPase activity;GO:0045019|negative regulation of nitric oxide biosynthetic process;GO:0045723|positive regulation of fatty acid biosynthetic process;GO:0050680|negative regulation of epithelial cell proliferation;GO:0050848|regulation of calcium-mediated signaling;GO:0051344|negative regulation of cyclic-nucleotide phosphodiesterase activity;GO:0097421|liver regeneration;GO:1901318|negative regulation of flagellated sperm motility;GO:1901671|positive regulation of superoxide dismutase activity;GO:1901896|positive regulation of calcium-transporting ATPase activity;GO:1902679|negative regulation of RNA biosynthetic process;GO:1903011|negative regulation of bone development;GO:1903052|positive regulation of proteolysis involved in cellular protein catabolic process;GO:1903611|negative regulation of calcium-dependent ATPase activity;GO:1903625|negative regulation of DNA catabolic process;GO:1903629|positive regulation of dUTP diphosphatase activity;GO:1903634|negative regulation of leucine-tRNA ligase activity;GO:2000279|negative regulation of DNA biosynthetic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004341|gluconolactonase activity;GO:0005509|calcium ion binding;GO:0008270|zinc ion binding;GO:0030234|enzyme regulator activity;","K01053","gnl, RGN; gluconolactonase [EC:3.1.1.17]"]
["ENSRNOG00000017577",421,27.08311448,127,8.199356176,3.30307818,1.723811117,{"v":8.86127e-38,"d":"8.86E-38"},{"v":2.27254E-37,"d":"2.27E-37"},"up","yes","Bphl","protein_coding","chr17:30799629-30837288:-","gi|795157964|ref|XP_011839956.1|",1538,0,"PREDICTED: tubulin beta chain isoform X9 [Mandrillus leucophaeus]","gi|157819844|ref|NM_001109119.1|",1061,0,"Rattus norvegicus tubulin, beta 2A class IIa (Tubb2a), mRNA","P85108",595,0,"Tubulin beta-2A chain","ECU03g0820i",499,{"v":2E-170,"d":"2.00E-170"},"COG5023","pfam03953","Tubulin_C","Tubulin C-terminal domain. This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).","GO:1990966|ATP generation from poly-ADP-D-ribose;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;GO:0043231|intracellular membrane-bounded organelle;","GO:0004649|poly(ADP-ribose) glycohydrolase activity;GO:0047658|alpha-amino-acid esterase activity;","K18399","BPHL; valacyclovir hydrolase [EC:3.1.-.-]"]
["ENSRNOG00000013744",749,48.1834982,331,21.36997555,2.254728748,1.172953882,{"v":1.13528E-37,"d":"1.14E-37"},{"v":2.89721e-37,"d":"2.90E-37"},"up","yes","Akip1","protein_coding","chr1:163734798-163743648:+","gi|157817388|ref|NP_001101967.1|",1195,{"v":9e-159,"d":"9.00E-159"},"A-kinase-interacting protein 1 [Rattus norvegicus]","gi|157817387|ref|NM_001108497.1|",1783,0,"Rattus norvegicus A-kinase interacting protein 1 (Akip1), mRNA","Q9JJR5",370,{"v":8e-124,"d":"8.00E-124"},"A-kinase-interacting protein 1",".",".",".",".","pfam08659","KR","KR domain. This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group.","GO:0034446|substrate adhesion-dependent cell spreading;GO:1901222|regulation of NIK/NF-kappaB signaling;","GO:0005654|nucleoplasm;",".",".","."]
["ENSRNOG00000033087",305,19.62078365,67,4.325644597,4.535921342,2.181395623,{"v":2.03418e-37,"d":"2.03E-37"},{"v":5.1589e-37,"d":"5.16E-37"},"up","yes","Cdh23","protein_coding","chr20:28240645-28622419:-","gi|17865345|ref|NP_446096.1|",17024,0,"cadherin-23 precursor [Rattus norvegicus]","gi|17865344|ref|NM_053644.1|",10780,0,"Rattus norvegicus cadherin-related 23 (Cdh23), mRNA","P58365",6546,0,"Cadherin-23",".",".",".",".","pfam00028","Cadherin","Cadherin domain.",".",".",".",".","."]
["ENSRNOG00000012151",353,22.70864468,92,5.939691088,3.823202982,1.934781798,{"v":4.01698e-37,"d":"4.02E-37"},{"v":1.01335E-36,"d":"1.01E-36"},"up","yes","Itpripl1","protein_coding","chr3:114402270-114414497:-","gi|564342773|ref|XP_006234989.1|",2891,0,"PREDICTED: inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 isoform X1 [Rattus norvegicus]","gi|289579662|gb|AC096165.10|",4413,0,"Rattus norvegicus BAC CH230-11H2 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q66H52",1110,0,"Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1",".",".",".",".","pfam03281","Mab-21","Mab-21 protein. This family contains Mab-21 and Mab-21 like proteins. In C. elegans these proteins are required for several aspects of embryonic development.",".","GO:0016020|membrane;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000002579",935,60.1489597,462,29.82757916,2.016555195,1.011892894,{"v":4.87819e-37,"d":"4.88E-37"},{"v":1.22843E-36,"d":"1.23E-36"},"up","yes","Parm1","protein_coding","chr14:16468459-16577314:-","gi|81885474|sp|Q6P9X9.1|PARM1_RAT",1006,{"v":1e-121,"d":"1.00E-121"},"RecName: Full=Prostate androgen-regulated mucin-like protein 1 homolog; Short=PARM-1; AltName: Full=Castration-induced prostatic apoptosis-related protein 1; Short=CIPAR-1; AltName: Full=Prostatic androgen-repressed message 1 protein; Flags: Precursor","gi|74148094|dbj|AK161172.1|",1247,0,"Mus musculus 0 day neonate head cDNA, RIKEN full-length enriched library, clone:4831433I04 product:Castration induced prostatic apoptosis related protein-1, (CIPAR- 1) homolog [Rattus norvegicus], full insert sequence","Q6P9X9",392,{"v":4e-123,"d":"4.00E-123"},"Prostate androgen-regulated mucin-like protein 1 homolog",".",".",".",".","pfam01858","RB_A","Retinoblastoma-associated protein A domain. This domain has the cyclin fold as predicted.","GO:0006915|apoptotic process;GO:0051973|positive regulation of telomerase activity;","GO:0000139|Golgi membrane;GO:0005654|nucleoplasm;GO:0005769|early endosome;GO:0005770|late endosome;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0010008|endosome membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;",".",".","."]
["ENSRNOG00000006761",284,18.26984444,58,3.74458786,4.879000074,2.286585505,{"v":6.17733e-37,"d":"6.18E-37"},{"v":1.55148e-36,"d":"1.55E-36"},"up","yes","Sh3gl2","protein_coding","chr5:99653152-100113843:+","gi|398303839|ref|NP_446387.1|",1500,0,"endophilin-A1 [Rattus norvegicus]","gi|398303838|ref|NM_053935.1|",947,0,"Rattus norvegicus SH3-domain GRB2-like 2 (Sh3gl2), mRNA","O35179",582,0,"Endophilin-A1",".",".",".",".","pfam03114","BAR","BAR domain. BAR domains are dimerization, lipid binding and curvature sensing modules found in many different protein families. A BAR domain with an additional N-terminal amphipathic helix (an N-BAR) can drive membrane curvature. These N-BAR domains are found in amphiphysin, endophilin, BRAP and Nadrin. BAR domains are also frequently found alongside domains that determine lipid specificity, like pfam00169 and pfam00787 domains in beta centaurins and sorting nexins respectively.","GO:0001933|negative regulation of protein phosphorylation;GO:0002090|regulation of receptor internalization;GO:0010629|negative regulation of gene expression;GO:0016191|synaptic vesicle uncoating;GO:0031175|neuron projection development;GO:0048488|synaptic vesicle endocytosis;GO:0060988|lipid tube assembly;GO:0097484|dendrite extension;GO:0097749|membrane tubulation;GO:0097753|membrane bending;GO:0099050|vesicle scission;GO:1903527|positive regulation of membrane tubulation;GO:1905604|negative regulation of maintenance of permeability of blood-brain barrier;GO:1990416|cellular response to brain-derived neurotrophic factor stimulus;GO:2000369|regulation of clathrin-dependent endocytosis;","GO:0005769|early endosome;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0030672|synaptic vesicle membrane;GO:0043025|neuronal cell body;GO:0045202|synapse;GO:0048471|perinuclear region of cytoplasm;GO:0097441|basal dendrite;GO:0098684|photoreceptor ribbon synapse;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098686|hippocampal mossy fiber to CA3 synapse;GO:0098793|presynapse;GO:0098978|glutamatergic synapse;GO:0099523|presynaptic cytosol;","GO:0005515|protein binding;GO:0008022|protein C-terminus binding;GO:0008289|lipid binding;GO:0019901|protein kinase binding;GO:0042802|identical protein binding;","K11247","SH3GL; endophilin-A"]
["ENSRNOG00000015551",688,44.25934147,294,18.98118674,2.331747855,1.221411791,{"v":6.23173E-37,"d":"6.23E-37"},{"v":1.56445E-36,"d":"1.56E-36"},"up","yes","Fuca2","protein_coding","chr1:7885918-7900776:+","gi|51948408|ref|NP_001004218.1|",1766,0,"plasma alpha-L-fucosidase precursor [Rattus norvegicus]","gi|51948407|ref|NM_001004218.1|",1126,0,"Rattus norvegicus fucosidase, alpha-L- 2, plasma (Fuca2), mRNA","Q6AYS4",684,0,"Plasma alpha-L-fucosidase","TM0306",129,{"v":3e-31,"d":"3.00E-31"},"COG3669","pfam01120","Alpha_L_fucos","Alpha-L-fucosidase.","GO:0005975|carbohydrate metabolic process;GO:0006004|fucose metabolic process;GO:0009617|response to bacterium;GO:0016139|glycoside catabolic process;GO:2000535|regulation of entry of bacterium into host cell;","GO:0005615|extracellular space;GO:0005764|lysosome;","GO:0004560|alpha-L-fucosidase activity;","K01206","FUCA; alpha-L-fucosidase [EC:3.2.1.51]"]
["ENSRNOG00000068024",352,22.64431424,92,5.939691088,3.812372378,1.930689043,{"v":6.36072e-37,"d":"6.36E-37"},{"v":1.59614e-36,"d":"1.60E-36"},"up","yes","B3gnt8","protein_coding","chr1:81135499-81142263:+","gi|157819259|ref|NP_001100962.1|",1890,0,"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 [Rattus norvegicus]","gi|672035067|ref|XM_006228434.2|",2663,0,"PREDICTED: Rattus norvegicus UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 (B3gnt8), transcript variant X3, mRNA","Q8R3I9",717,0,"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8","VNG1926G",67.4,{"v":1E-10,"d":"1.00E-10"},"COG1071","pfam01762","Galactosyl_T","Galactosyltransferase. This family includes the galactosyltransferases UDP-galactose:2-acetamido-2-deoxy-D-glucose3beta-galactosyltransferase and UDP-Gal:beta-GlcNAc beta 1,3-galactosyltranferase. Specific galactosyltransferases transfer galactose to GlcNAc terminal chains in the synthesis of the lacto-series oligosaccharides types 1 and 2.",".",".",".",".","."]
["ENSRNOG00000038784",701,45.09563717,303,19.56224348,2.305238518,1.204916031,{"v":7.79129e-37,"d":"7.79E-37"},{"v":1.94998e-36,"d":"1.95E-36"},"up","yes","Piezo2","protein_coding","chr18:56469680-56844216:-","gi|293343114|ref|XP_001063568.2|",12651,0,"PREDICTED: piezo-type mechanosensitive ion channel component 2 isoform X2 [Rattus norvegicus]","gi|672030768|ref|XM_001063568.5|",5817,0,"PREDICTED: Rattus norvegicus piezo-type mechanosensitive ion channel component 2 (Piezo2), transcript variant X2, mRNA","Q8CD54",4772,0,"Piezo-type mechanosensitive ion channel component 2",".",".",".",".","pfam12166","DUF3595","Protein of unknown function (DUF3595). This family of proteins is functionally uncharacterized.This family of proteins is found in eukaryotes. Proteins in this family are typically between 578 and 2525 amino acids in length.","GO:0006812|cation transport;GO:0009612|response to mechanical stimulus;GO:0042391|regulation of membrane potential;GO:0050974|detection of mechanical stimulus involved in sensory perception;GO:0050982|detection of mechanical stimulus;GO:0071260|cellular response to mechanical stimulus;GO:0098655|cation transmembrane transport;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0005261|cation channel activity;GO:0008381|mechanosensitive ion channel activity;GO:0140135|mechanosensitive cation channel activity;","K22128","PIEZO1_2, FAM38; piezo-type mechanosensitive ion channel component 1/2"]
["ENSRNOG00000047052",916,58.92668138,450,29.05283684,2.028259123,1.020241978,{"v":8.5964e-37,"d":"8.60E-37"},{"v":2.14865e-36,"d":"2.15E-36"},"up","yes","Clpp","protein_coding","chr9:1830311-1837693:+","gi|564311031|ref|XP_001055676.4|",1494,0,"PREDICTED: ATP-dependent Clp protease proteolytic subunit, mitochondrial [Rattus norvegicus]","gi|672023573|ref|XM_001055676.5|",2697,0,"PREDICTED: Rattus norvegicus caseinolytic mitochondrial matrix peptidase proteolytic subunit (Clpp), mRNA","O88696",433,{"v":2e-143,"d":"2.00E-143"},"ATP-dependent Clp protease proteolytic subunit, mitochondrial","RP520",234,{"v":6e-70,"d":"6.00E-70"},"COG0740","pfam00574","CLP_protease","Clp protease. The Clp protease has an active site catalytic triad. In Escherichia coli Clp protease, ser-111, his-136 and asp-185 form the catalytic triad. Cyanophora parodoxa clpP-B has lost all of these active site residues and is therefore inactive. Some members contain one or two large insertions.","GO:0006515|protein quality control for misfolded or incompletely synthesized proteins;GO:0033619|membrane protein proteolysis;GO:0051603|proteolysis involved in cellular protein catabolic process;","GO:0005739|mitochondrion;GO:0005759|mitochondrial matrix;GO:0009368|endopeptidase Clp complex;","GO:0004175|endopeptidase activity;GO:0004176|ATP-dependent peptidase activity;GO:0004252|serine-type endopeptidase activity;GO:0005515|protein binding;GO:0042802|identical protein binding;GO:0051117|ATPase binding;","K01358","clpP, CLPP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]"]
["ENSRNOG00000009447",353,22.70864468,93,6.004252948,3.782093272,1.919184943,{"v":9.62972e-37,"d":"9.63E-37"},{"v":2.40272E-36,"d":"2.40E-36"},"up","yes","Fam221a","protein_coding","chr4:78337296-78358909:+","gi|148666193|gb|EDK98609.1|",1439,0,"RIKEN cDNA D330028D13, isoform CRA_b, partial [Mus musculus]","gi|672049609|ref|XM_006236468.2|",1344,0,"PREDICTED: Rattus norvegicus family with sequence similarity 221, member A (Fam221a), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam14753","DUF4475","Domain of unknown function (DUF4475). This family of proteins is found in eukaryotes. Proteins in this family are typically between 99 and 305 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000006931",824,53.00828106,389,25.11456341,2.110659071,1.077693563,{"v":3.14662e-36,"d":"3.15E-36"},{"v":7.7798e-36,"d":"7.78E-36"},"up","yes","Eepd1","protein_coding","chr8:23957255-24064340:+","gi|50511063|dbj|BAD32517.1|",3144,0,"mKIAA1706 protein [Mus musculus]","gi|672061281|ref|XM_006242726.2|",2694,0,"PREDICTED: Rattus norvegicus endonuclease/exonuclease/phosphatase family domain containing 1 (Eepd1), transcript variant X1, mRNA","Q5XI74",1174,0,"Endonuclease/exonuclease/phosphatase family domain-containing protein 1","TM1052",91.3,{"v":1e-19,"d":"1.00E-19"},"COG1555","pfam12836","HHH_3","Helix-hairpin-helix motif. The HhH domain is a short DNA-binding domain.","GO:0006281|DNA repair;GO:0010875|positive regulation of cholesterol efflux;","GO:0046658|anchored component of plasma membrane;","GO:0003677|DNA binding;",".","."]
["ENSRNOG00000048818",506,32.55120172,182,11.75025846,2.770254105,1.470018315,{"v":3.90385e-36,"d":"3.90E-36"},{"v":9.62283e-36,"d":"9.62E-36"},"up","yes","Catsperd","protein_coding","chr9:1460001-1498344:+","gi|564366897|ref|XP_006244402.1|",4059,0,"PREDICTED: cation channel sperm-associated protein subunit delta isoform X3 [Rattus norvegicus]","gi|672063991|ref|XM_006244344.2|",2273,0,"PREDICTED: Rattus norvegicus catsper channel auxiliary subunit delta (Catsperd), transcript variant X6, mRNA","B5DFM7",1420,0,"Cation channel sperm-associated protein subunit delta",".",".",".",".","pfam15020","CATSPERD","Cation channel sperm-associated protein subunit delta. The CATSPER (cation channel of sperm) complex is a tetrameric complex consisting of CATSPER1, CATSPER2, CATSPER3 and CATSPER4, it functions as an alkalinisation-activated calcium channel. This complex requires several auxiliary subunits, including CATSPERD. CATSPERD is essential for the cation channel function and may play a role in channel assembly or transport.","GO:0007283|spermatogenesis;GO:0030317|flagellated sperm motility;GO:0048240|sperm capacitation;","GO:0036128|CatSper complex;GO:0097228|sperm principal piece;",".","K16895","CATSPERD; cation channel sperm-associated protein subunit delta"]
["ENSRNOG00000015880",715,45.9962633,316,20.40154765,2.254547747,1.172838064,{"v":4.92856e-36,"d":"4.93E-36"},{"v":1.21069E-35,"d":"1.21E-35"},"up","yes","Dpep1","protein_coding","chr19:51219660-51235257:+","gi|16758372|ref|NP_446043.1|",2017,0,"dipeptidase 1 precursor [Rattus norvegicus]","gi|459932|gb|L07315.1|RATDPEP1Y",2157,0,"Rat dipeptidase (dpep1) mRNA, complete cds","P31430",781,0,"Dipeptidase 1","SPCC965.12",259,{"v":2e-77,"d":"2.00E-77"},"COG2355","pfam01244","Peptidase_M19","Membrane dipeptidase (Peptidase family M19).","GO:0006507|GPI anchor release;GO:0006508|proteolysis;GO:0006629|lipid metabolic process;GO:0006691|leukotriene metabolic process;GO:0006751|glutathione catabolic process;GO:0006915|apoptotic process;GO:0006954|inflammatory response;GO:0016999|antibiotic metabolic process;GO:0030336|negative regulation of cell migration;GO:0030593|neutrophil chemotaxis;GO:0032869|cellular response to insulin stimulus;GO:0043066|negative regulation of apoptotic process;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0050667|homocysteine metabolic process;GO:0071277|cellular response to calcium ion;GO:0071466|cellular response to xenobiotic stimulus;GO:0071732|cellular response to nitric oxide;","GO:0005615|extracellular space;GO:0005654|nucleoplasm;GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0016324|apical plasma membrane;GO:0030054|cell junction;GO:0031225|anchored component of membrane;GO:0031528|microvillus membrane;GO:0045177|apical part of cell;","GO:0008270|zinc ion binding;GO:0008800|beta-lactamase activity;GO:0016805|dipeptidase activity;GO:0034235|GPI anchor binding;GO:0042802|identical protein binding;GO:0043027|cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0070573|metallodipeptidase activity;GO:0072341|modified amino acid binding;","K01273","DPEP; membrane dipeptidase [EC:3.4.13.19]"]
["ENSRNOG00000020153",658,42.32942833,279,18.01275884,2.349969191,1.232641843,{"v":6.94037e-36,"d":"6.94E-36"},{"v":1.70123E-35,"d":"1.70E-35"},"up","yes","Supt3h","protein_coding","chr9:15868287-16206706:-","gi|568998626|ref|XP_006523540.1|",1826,0,"PREDICTED: transcription initiation protein SPT3 homolog isoform X4 [Mus musculus]","gi|672064531|ref|XM_008766909.1|",3321,0,"PREDICTED: Rattus norvegicus suppressor of Ty 3 homolog (S. cerevisiae) (Supt3h), transcript variant X6, mRNA","O75486",448,{"v":8e-144,"d":"8.00E-144"},"Transcription initiation protein SPT3 homolog",".",".",".",".","pfam02269","TFIID-18kDa","Transcription initiation factor IID, 18kD subunit. This family includes the Spt3 yeast transcription factors and the 18kD subunit from human transcription initiation factor IID (TFIID-18). Determination of the crystal structure reveals an atypical histone fold","GO:0006366|transcription by RNA polymerase II;GO:0008150|biological_process;GO:0016578|histone deubiquitination;GO:0043966|histone H3 acetylation;GO:0045893|positive regulation of transcription, DNA-templated;","GO:0000124|SAGA complex;GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0033276|transcription factor TFTC complex;","GO:0003674|molecular_function;GO:0003713|transcription coactivator activity;","K11313","SUPT3H, SPT3; transcription initiation protein SPT3"]
["ENSRNOG00000019372",686,44.13068059,298,19.23943418,2.293761874,1.197715626,{"v":9.28725e-36,"d":"9.29E-36"},{"v":2.26968e-35,"d":"2.27E-35"},"up","yes","Pc","protein_coding","chr1:201804267-201898380:+","gi|564332046|ref|XP_006230752.1|",5639,0,"PREDICTED: pyruvate carboxylase, mitochondrial isoform X3 [Rattus norvegicus]","gi|672039198|ref|XM_006230690.2|",4317,0,"PREDICTED: Rattus norvegicus pyruvate carboxylase (Pc), transcript variant X2, mRNA","P52873",2172,0,"Pyruvate carboxylase, mitochondrial","SPBC17G9.11c",1125,0,"COG1038","pfam02436","PYC_OADA","Conserved carboxylase domain. This domain represents a conserved region in pyruvate carboxylase (PYC), oxaloacetate decarboxylase alpha chain (OADA), and transcarboxylase 5s subunit. The domain is found adjacent to the HMGL-like domain (pfam00682) and often close to the biotin_lipoyl domain (pfam00364) of biotin requiring enzymes.","GO:0006090|pyruvate metabolic process;GO:0006094|gluconeogenesis;GO:0006107|oxaloacetate metabolic process;GO:0006629|lipid metabolic process;GO:0010629|negative regulation of gene expression;GO:0019074|viral RNA genome packaging;GO:0044791|positive regulation by host of viral release from host cell;GO:0044794|positive regulation by host of viral process;GO:0071073|positive regulation of phospholipid biosynthetic process;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005759|mitochondrial matrix;","GO:0004736|pyruvate carboxylase activity;GO:0005524|ATP binding;GO:0009374|biotin binding;GO:0031406|carboxylic acid binding;GO:0042802|identical protein binding;GO:0046872|metal ion binding;","K01958","PC, pyc; pyruvate carboxylase [EC:6.4.1.1]"]
["ENSRNOG00000053163",629,40.46384562,261,16.85064537,2.401323197,1.263829591,{"v":1.10353E-35,"d":"1.10E-35"},{"v":2.69456E-35,"d":"2.69E-35"},"up","yes","AABR07050084.1","snoRNA","chr5:144505211-144505346:+",".",".",".",".","gi|908662240|tpe|LN871982.1|",111,{"v":6e-50,"d":"6.00E-50"},"TPA: Mus musculus SNORA16 (ACA16) gene for small nucleolar RNA SNORA16 (ACA16)",".",".",".",".",".",".",".",".","pfam14026","DUF4242","Protein of unknown function (DUF4242). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 90 and 170 amino acids in length. There is a single completely conserved residue C that may be functionally important.",".",".",".",".","."]
["ENSRNOG00000001391",336,21.61502723,87,5.61688179,3.84822541,1.944193308,{"v":1.23404e-35,"d":"1.23E-35"},{"v":3.0094e-35,"d":"3.01E-35"},"up","yes","Sdsl","protein_coding","chr12:36099693-36109906:+","gi|157820447|ref|NP_001101806.1|",1483,0,"serine dehydratase-like [Rattus norvegicus]","gi|157820446|ref|NM_001108336.1|",909,0,"Rattus norvegicus serine dehydratase-like (Sdsl), mRNA","Q8R238",526,0,"Serine dehydratase-like","YCL064c",147,{"v":9e-39,"d":"9.00E-39"},"COG1171","pfam00291","PALP","Pyridoxal-phosphate dependent enzyme. Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.","GO:0006567|threonine catabolic process;GO:0008150|biological_process;GO:0009097|isoleucine biosynthetic process;","GO:0005575|cellular_component;","GO:0003674|molecular_function;GO:0004794|L-threonine ammonia-lyase activity;GO:0042802|identical protein binding;","K17989","SDS, SDH, CHA1; L-serine/L-threonine ammonia-lyase [EC:4.3.1.17 4.3.1.19]"]
["ENSRNOG00000018938",650,41.81478482,275,17.75451141,2.355163928,1.23582748,{"v":1.31713e-35,"d":"1.32E-35"},{"v":3.2079e-35,"d":"3.21E-35"},"up","yes","Mkx","protein_coding","chr17:55077540-55156124:-","gi|148691080|gb|EDL23027.1|",1927,0,"mohawk, partial [Mus musculus]","gi|672030195|ref|XM_008774010.1|",3133,0,"PREDICTED: Rattus norvegicus mohawk homeobox (Mkx), transcript variant X2, mRNA","Q8BIA3",662,0,"Homeobox protein Mohawk",".",".",".",".","pfam05920","Homeobox_KN","Homeobox KN domain. This is a homeobox transcription factor KN domain conserved from fungi to human and plants.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0002932|tendon sheath development;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007517|muscle organ development;GO:0010468|regulation of gene expression;GO:0010628|positive regulation of gene expression;GO:0030199|collagen fibril organization;GO:0030279|negative regulation of ossification;GO:0032331|negative regulation of chondrocyte differentiation;GO:0032967|positive regulation of collagen biosynthetic process;GO:0035990|tendon cell differentiation;GO:0035992|tendon formation;GO:0036077|intratendonous ossification;GO:0045599|negative regulation of fat cell differentiation;GO:0045662|negative regulation of myoblast differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048468|cell development;GO:0071260|cellular response to mechanical stimulus;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;","K24890","MKX; homeobox protein Mohawk"]
["ENSRNOG00000003063",793,51.01403748,371,23.95244993,2.129804576,1.09072106,{"v":1.38619e-35,"d":"1.39E-35"},{"v":3.37322e-35,"d":"3.37E-35"},"up","yes","Phka1","protein_coding","chrX:67601302-67738455:-","gi|815891310|ref|NP_072148.2|",6498,0,"phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform [Rattus norvegicus]","gi|815891309|ref|NM_022626.2|",4359,0,"Rattus norvegicus phosphorylase kinase, alpha 1 (Phka1), mRNA","Q64649",2456,0,"Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform",".",".",".",".","pfam00723","Glyco_hydro_15","Glycosyl hydrolases family 15. In higher organisms this family is represented by phosphorylase kinase subunits.","GO:0005977|glycogen metabolic process;GO:0006656|phosphatidylcholine biosynthetic process;GO:0006657|CDP-choline pathway;GO:0046777|protein autophosphorylation;","GO:0005886|plasma membrane;GO:0005964|phosphorylase kinase complex;","GO:0004105|choline-phosphate cytidylyltransferase activity;GO:0005516|calmodulin binding;","K07190","PHKA_B; phosphorylase kinase alpha/beta subunit"]
["ENSRNOG00000019990",858,55.19551596,416,26.85773362,2.055106985,1.0392135,{"v":1.39857E-35,"d":"1.40E-35"},{"v":3.40191E-35,"d":"3.40E-35"},"up","yes","Rex1bd","protein_coding","chr16:18922037-18924526:+","gi|564388564|ref|XP_006252958.1|",623,{"v":7e-78,"d":"7.00E-78"},"PREDICTED: uncharacterized protein C19orf60 homolog isoform X1 [Rattus norvegicus]","gi|354793648|gb|JN958149.1|",410,0,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele 2810422J05Rik:tm1e(EUCOMM)Hmgu; transgenic",".",".",".",".",".",".",".",".","pfam14966","DNA_repr_REX1B","DNA repair REX1-B. This family of proteins includes Chlamydomonas reinhardtii REX1-B (Required for Excision 1-B) which is involved in a light-independent DNA repair pathway.",".",".",".",".","."]
["ENSRNOG00000004332",447,28.75570587,149,9.619717089,2.989246524,1.579781881,{"v":1.60528e-35,"d":"1.61E-35"},{"v":3.89805e-35,"d":"3.90E-35"},"up","yes","Egfr","protein_coding","chr14:91177067-91344382:+","gi|149044710|gb|EDL97896.1|",5998,0,"epidermal growth factor receptor, isoform CRA_b [Rattus norvegicus]","gi|25742616|ref|NM_031507.1|",4107,0,"Rattus norvegicus epidermal growth factor receptor (Egfr), mRNA","Q01279",2230,0,"Epidermal growth factor receptor",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0000902|cell morphogenesis;GO:0001889|liver development;GO:0001892|embryonic placenta development;GO:0001934|positive regulation of protein phosphorylation;GO:0001942|hair follicle development;GO:0006412|translation;GO:0006898|receptor-mediated endocytosis;GO:0006970|response to osmotic stress;GO:0006979|response to oxidative stress;GO:0007165|signal transduction;GO:0007166|cell surface receptor signaling pathway;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007173|epidermal growth factor receptor signaling pathway;GO:0007275|multicellular organism development;GO:0007435|salivary gland morphogenesis;GO:0007494|midgut development;GO:0007611|learning or memory;GO:0007623|circadian rhythm;GO:0008284|positive regulation of cell proliferation;GO:0008544|epidermis development;GO:0010750|positive regulation of nitric oxide mediated signal transduction;GO:0010960|magnesium ion homeostasis;GO:0014066|regulation of phosphatidylinositol 3-kinase signaling;GO:0014070|response to organic cyclic compound;GO:0016101|diterpenoid metabolic process;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0021795|cerebral cortex cell migration;GO:0030154|cell differentiation;GO:0030307|positive regulation of cell growth;GO:0030324|lung development;GO:0030335|positive regulation of cell migration;GO:0032355|response to estradiol;GO:0032930|positive regulation of superoxide anion generation;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0033590|response to cobalamin;GO:0033594|response to hydroxyisoflavone;GO:0033674|positive regulation of kinase activity;GO:0033993|response to lipid;GO:0034614|cellular response to reactive oxygen species;GO:0035556|intracellular signal transduction;GO:0038083|peptidyl-tyrosine autophosphorylation;GO:0042060|wound healing;GO:0042127|regulation of cell proliferation;GO:0042177|negative regulation of protein catabolic process;GO:0042311|vasodilation;GO:0042327|positive regulation of phosphorylation;GO:0042698|ovulation cycle;GO:0042743|hydrogen peroxide metabolic process;GO:0043066|negative regulation of apoptotic process;GO:0043406|positive regulation of MAP kinase activity;GO:0043410|positive regulation of MAPK cascade;GO:0043586|tongue development;GO:0045737|positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045739|positive regulation of DNA repair;GO:0045740|positive regulation of DNA replication;GO:0045780|positive regulation of bone resorption;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045907|positive regulation of vasoconstriction;GO:0045930|negative regulation of mitotic cell cycle;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046328|regulation of JNK cascade;GO:0046777|protein autophosphorylation;GO:0048143|astrocyte activation;GO:0048146|positive regulation of fibroblast proliferation;GO:0048546|digestive tract morphogenesis;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0048812|neuron projection morphogenesis;GO:0050679|positive regulation of epithelial cell proliferation;GO:0050729|positive regulation of inflammatory response;GO:0050730|regulation of peptidyl-tyrosine phosphorylation;GO:0050999|regulation of nitric-oxide synthase activity;GO:0051592|response to calcium ion;GO:0051897|positive regulation of protein kinase B signaling;GO:0051968|positive regulation of synaptic transmission, glutamatergic;GO:0060252|positive regulation of glial cell proliferation;GO:0060571|morphogenesis of an epithelial fold;GO:0061029|eyelid development in camera-type eye;GO:0070141|response to UV-A;GO:0070257|positive regulation of mucus secretion;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071230|cellular response to amino acid stimulus;GO:0071260|cellular response to mechanical stimulus;GO:0071276|cellular response to cadmium ion;GO:0071363|cellular response to growth factor stimulus;GO:0071364|cellular response to epidermal growth factor stimulus;GO:0071392|cellular response to estradiol stimulus;GO:0071466|cellular response to xenobiotic stimulus;GO:0071549|cellular response to dexamethasone stimulus;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:0097421|liver regeneration;GO:0098609|cell-cell adhesion;GO:1900020|positive regulation of protein kinase C activity;GO:1900087|positive regulation of G1/S transition of mitotic cell cycle;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1902722|positive regulation of prolactin secretion;GO:1903078|positive regulation of protein localization to plasma membrane;GO:1903800|positive regulation of production of miRNAs involved in gene silencing by miRNA;GO:1905208|negative regulation of cardiocyte differentiation;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009925|basal plasma membrane;GO:0009986|cell surface;GO:0010008|endosome membrane;GO:0016020|membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0030054|cell junction;GO:0030139|endocytic vesicle;GO:0031901|early endosome membrane;GO:0032587|ruffle membrane;GO:0032991|protein-containing complex;GO:0043235|receptor complex;GO:0045121|membrane raft;GO:0045202|synapse;GO:0048471|perinuclear region of cytoplasm;GO:0097489|multivesicular body, internal vesicle lumen;GO:0097708|intracellular vesicle;","GO:0003682|chromatin binding;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004888|transmembrane signaling receptor activity;GO:0005006|epidermal growth factor-activated receptor activity;GO:0005102|signaling receptor binding;GO:0005178|integrin binding;GO:0005515|protein binding;GO:0005516|calmodulin binding;GO:0005524|ATP binding;GO:0016301|kinase activity;GO:0019899|enzyme binding;GO:0019900|kinase binding;GO:0019901|protein kinase binding;GO:0019903|protein phosphatase binding;GO:0030235|nitric-oxide synthase regulator activity;GO:0031625|ubiquitin protein ligase binding;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;GO:0048408|epidermal growth factor binding;GO:0051015|actin filament binding;","K04361","EGFR, ERBB1; epidermal growth factor receptor [EC:2.7.10.1]"]
["ENSRNOG00000056651",716,46.06059374,320,20.65979509,2.229479699,1.156707063,{"v":2.4905e-35,"d":"2.49E-35"},{"v":6.03224e-35,"d":"6.03E-35"},"up","yes","ENSRNOG00000056651","protein_coding","chr1:84549831-84550664:-","gi|293355807|ref|XP_002728770.1|",222,{"v":7e-20,"d":"7.00E-20"},"PREDICTED: immortalization up-regulated protein-like [Rattus norvegicus]","gi|298886976|emb|FQ220383.1|",347,{"v":2E-180,"d":"2.00E-180"},"Rattus norvegicus TL0ADA43YB16 mRNA sequence",".",".",".",".",".",".",".",".","pfam07188","KSHV_K8","Kaposi's sarcoma-associated herpesvirus (KSHV) K8 protein. This family consists of Kaposi's sarcoma-associated herpesvirus (KSHV) K8 proteins. KSHV is a human Gammaherpesvirus related to Epstein-Barr virus (EBV) and herpesvirus saimiri. KSHV open reading frame K8 encodes a basic region-leucine zipper protein of 237 aa that homodimerises. K8 interacts and co-localizes with human pfam04855, a cellular chromatin-remodelling factor, both in vivo and in vitro. K8 is thought to function as a transcriptional activator under specific conditions and its transactivation activity requires its interaction with the cellular chromatin remodelling factor hSNF5.",".","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005829|cytosol;GO:0005886|plasma membrane;",".",".","."]
["ENSRNOG00000006096",176,11.32215712,16,1.032989754,10.96057059,3.454250999,{"v":6.00609e-35,"d":"6.01E-35"},{"v":1.44371E-34,"d":"1.44E-34"},"up","yes","Slc26a7","protein_coding","chr5:27887042-28021658:-","gi|568926289|ref|XP_006537785.1|",3239,0,"PREDICTED: anion exchange transporter isoform X1 [Mus musculus]","gi|755506183|ref|XM_006537723.2|",2033,0,"PREDICTED: Mus musculus solute carrier family 26, member 7 (Slc26a7), transcript variant X2, mRNA","Q8R2Z3",1165,0,"Anion exchange transporter","lin0529",113,{"v":3e-25,"d":"3.00E-25"},"COG0659","pfam00916","Sulfate_transp","Sulfate transporter family. Mutations in human SLC26A2 lead to several human diseases.","GO:0001696|gastric acid secretion;GO:0006820|anion transport;GO:0006821|chloride transport;GO:0008272|sulfate transport;GO:0015701|bicarbonate transport;GO:0019532|oxalate transport;GO:1902358|sulfate transmembrane transport;GO:1902476|chloride transmembrane transport;","GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005887|integral component of plasma membrane;GO:0016323|basolateral plasma membrane;","GO:0005253|anion channel activity;GO:0005254|chloride channel activity;GO:0008271|secondary active sulfate transmembrane transporter activity;GO:0015106|bicarbonate transmembrane transporter activity;GO:0015108|chloride transmembrane transporter activity;GO:0015116|sulfate transmembrane transporter activity;GO:0015301|anion:anion antiporter activity;GO:0019531|oxalate transmembrane transporter activity;","K13962","SLC26A7, SUT2; solute carrier family 26 (anion exchange transporter), member 7"]
["ENSRNOG00000004608",745,47.92617645,342,22.080156,2.17055425,1.118063481,{"v":7.8028e-35,"d":"7.80E-35"},{"v":1.87402E-34,"d":"1.87E-34"},"up","yes","Pam16","protein_coding","chr10:10943001-10950649:+","gi|562821831|ref|XP_006140806.1|",472,{"v":9e-57,"d":"9.00E-57"},"PREDICTED: mitochondrial import inner membrane translocase subunit TIM16 isoform X2 [Tupaia chinensis]","gi|298888551|emb|FQ220566.1|",506,0,"Rattus norvegicus TL0ADA42YG17 mRNA sequence","Q9CQV1",174,{"v":4e-54,"d":"4.00E-54"},"Mitochondrial import inner membrane translocase subunit TIM16",".",".",".",".","pfam03656","Pam16","Pam16. The Pam16 protein is the fifth essential subunit of the pre-sequence translocase-associated protein import motor (PAM). In Saccharomyces cerevisiae, Pam16 is required for preprotein translocation into the matrix, but not for protein insertion into the inner membrane. Pam16 has a degenerate J domain. J-domain proteins play important regulatory roles as co-chaperones, recruiting Hsp70 partners and accelerating the ATP-hydrolysis step of the chaperone cycle. Pam16's J-like domain strongly interacts with Pam18's J domain, leading to a productive interaction of Pam18 with mtHsp70 at the mitochondria import channel. Pam18 stimulates the ATPase activity of mtHsp70.","GO:0001503|ossification;GO:0030150|protein import into mitochondrial matrix;GO:0032780|negative regulation of ATPase activity;GO:0043066|negative regulation of apoptotic process;GO:0071897|DNA biosynthetic process;GO:0090201|negative regulation of release of cytochrome c from mitochondria;GO:1902511|negative regulation of apoptotic DNA fragmentation;GO:2001234|negative regulation of apoptotic signaling pathway;","GO:0001405|PAM complex, Tim23 associated import motor;GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005744|TIM23 mitochondrial import inner membrane translocase complex;GO:0005759|mitochondrial matrix;GO:0031314|extrinsic component of mitochondrial inner membrane;GO:0032991|protein-containing complex;","GO:0003674|molecular_function;","K17805","PAM16, TIM16; mitochondrial import inner membrane translocase subunit TIM16"]
["ENSRNOG00000019433",524,33.70914961,198,12.78324821,2.636978415,1.398885762,{"v":8.46873E-35,"d":"8.47E-35"},{"v":2.03054e-34,"d":"2.03E-34"},"up","yes","Rab3a","protein_coding","chr16:18684188-18688336:-","gi|6679593|ref|NP_033027.1|",1189,{"v":2e-157,"d":"2.00E-157"},"ras-related protein Rab-3A [Mus musculus]","gi|61098194|ref|NM_013018.2|",1268,0,"Rattus norvegicus RAB3A, member RAS oncogene family (Rab3a), mRNA","P63012",462,{"v":5e-159,"d":"5.00E-159"},"Ras-related protein Rab-3A",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0001778|plasma membrane repair;GO:0003016|respiratory system process;GO:0006887|exocytosis;GO:0006904|vesicle docking involved in exocytosis;GO:0007005|mitochondrion organization;GO:0007274|neuromuscular synaptic transmission;GO:0007409|axonogenesis;GO:0009306|protein secretion;GO:0009791|post-embryonic development;GO:0010807|regulation of synaptic vesicle priming;GO:0014059|regulation of dopamine secretion;GO:0016079|synaptic vesicle exocytosis;GO:0016188|synaptic vesicle maturation;GO:0017156|calcium ion regulated exocytosis;GO:0017157|regulation of exocytosis;GO:0030324|lung development;GO:0031630|regulation of synaptic vesicle fusion to presynaptic active zone membrane;GO:0032418|lysosome localization;GO:0032482|Rab protein signal transduction;GO:0036465|synaptic vesicle recycling;GO:0045055|regulated exocytosis;GO:0048172|regulation of short-term neuronal synaptic plasticity;GO:0048489|synaptic vesicle transport;GO:0048790|maintenance of presynaptic active zone structure;GO:0050790|regulation of catalytic activity;GO:0050975|sensory perception of touch;GO:0051602|response to electrical stimulus;GO:0060478|acrosomal vesicle exocytosis;GO:0061670|evoked neurotransmitter secretion;GO:0072659|protein localization to plasma membrane;GO:0097091|synaptic vesicle clustering;GO:1903307|positive regulation of regulated secretory pathway;GO:1905684|regulation of plasma membrane repair;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0001669|acrosomal vesicle;GO:0005764|lysosome;GO:0005768|endosome;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0008021|synaptic vesicle;GO:0016020|membrane;GO:0030141|secretory granule;GO:0030424|axon;GO:0032991|protein-containing complex;GO:0043195|terminal bouton;GO:0043229|intracellular organelle;GO:0048471|perinuclear region of cytoplasm;GO:0048786|presynaptic active zone;GO:0098993|anchored component of synaptic vesicle membrane;","GO:0001671|ATPase activator activity;GO:0003924|GTPase activity;GO:0005515|protein binding;GO:0005525|GTP binding;GO:0008022|protein C-terminus binding;GO:0030742|GTP-dependent protein binding;GO:0031489|myosin V binding;GO:0051021|GDP-dissociation inhibitor binding;GO:0051117|ATPase binding;","K07882","RAB3A; Ras-related protein Rab-3A"]
["ENSRNOG00000000033",488,31.39325383,176,11.3628873,2.762788454,1.4661251,{"v":8.85654e-35,"d":"8.86E-35"},{"v":2.12264e-34,"d":"2.12E-34"},"up","yes","Tmcc2","protein_coding","chr13:43794029-43831716:-","gi|760997468|ref|NP_001292057.1|",2836,0,"transmembrane and coiled-coil domains protein 2 [Rattus norvegicus]","gi|760997467|ref|NM_001305128.1|",3516,0,"Rattus norvegicus transmembrane and coiled-coil domain family 2 (Tmcc2), mRNA","Q80W04",1080,0,"Transmembrane and coiled-coil domains protein 2",".",".",".",".","pfam10267","Tmemb_cc2","Predicted transmembrane and coiled-coil 2 protein. This family of transmembrane coiled-coil containing proteins is conserved from worms to humans. Its function is unknown.","GO:0042982|amyloid precursor protein metabolic process;","GO:0005783|endoplasmic reticulum;GO:0012505|endomembrane system;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000012795",747,48.05483732,344,22.20927972,2.163727862,1.113519059,{"v":1.04922E-34,"d":"1.05E-34"},{"v":2.51044E-34,"d":"2.51E-34"},"up","yes","Cables1","protein_coding","chr18:3075524-3181181:+","gi|226371633|ref|NP_001139759.1|",2441,0,"CDK5 and ABL1 enzyme substrate 1 isoform 1 [Mus musculus]","gi|74220959|dbj|AK156273.1|",2567,0,"Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830014H21 product:Cdk5 and Abl enzyme substrate 1, full insert sequence","Q9ESJ1",877,0,"CDK5 and ABL1 enzyme substrate 1",".",".",".",".","pfam00134","Cyclin_N","Cyclin, N-terminal domain. Cyclins regulate cyclin dependent kinases (CDKs). Human cyclin-O is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.","GO:0007399|nervous system development;GO:0051726|regulation of cell cycle;","GO:0005829|cytosol;",".",".","."]
["ENSRNOG00000020635",854,54.93819421,419,27.0514192,2.030880296,1.022105207,{"v":1.6244E-34,"d":"1.62E-34"},{"v":3.86722e-34,"d":"3.87E-34"},"up","yes","Exosc5","protein_coding","chr1:81166023-81177265:+","gi|312596907|ref|NP_001100963.2|",797,{"v":3e-101,"d":"3.00E-101"},"exosome complex component RRP46 [Rattus norvegicus]","gi|672035068|ref|XM_006228437.2|",794,0,"PREDICTED: Rattus norvegicus exosome component 5 (Exosc5), transcript variant X1, mRNA","Q9CRA8",304,{"v":6e-100,"d":"6.00E-100"},"Exosome complex component RRP46","AF0493",61.6,{"v":5e-10,"d":"5.00E-10"},"COG0689","pfam01138","RNase_PH","3' exoribonuclease family, domain 1. This family includes 3'-5' exoribonucleases. Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of the domain. PNPase is involved in mRNA degradation in a 3'-5' direction. The exosome is a 3'-5' exoribonuclease complex that is required for 3' processing of the 5.8S rRNA. Three of its five protein components contain a copy of this domain. A hypothetical protein from S. pombe appears to belong to an uncharacterized subfamily. This subfamily is found in both eukaryotes and archaebacteria.","GO:0006401|RNA catabolic process;GO:0008150|biological_process;GO:0016075|rRNA catabolic process;GO:0034427|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5';GO:0034475|U4 snRNA 3'-end processing;GO:0043928|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;GO:0045006|DNA deamination;GO:0051607|defense response to virus;GO:0071028|nuclear mRNA surveillance;GO:0071051|polyadenylation-dependent snoRNA 3'-end processing;","GO:0000176|nuclear exosome (RNase complex);GO:0000177|cytoplasmic exosome (RNase complex);GO:0000178|exosome (RNase complex);GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0035327|transcriptionally active chromatin;","GO:0003674|molecular_function;","K12590","RRP46, EXOSC5; exosome complex component RRP46"]
["ENSRNOG00000067691",415,26.69713185,134,8.651289194,3.0859137,1.625697716,{"v":1.99446e-34,"d":"1.99E-34"},{"v":4.73835e-34,"d":"4.74E-34"},"up","yes","ENSRNOG00000067691","pseudogene","chr6:87540628-87541251:+","gi|393393852|ref|NP_001257315.1|",465,{"v":2e-57,"d":"2.00E-57"},"uncharacterized protein LOC688925 [Rattus norvegicus]","gi|393393851|ref|NM_001270386.1|",288,{"v":7e-148,"d":"7.00E-148"},"Rattus norvegicus similar to Glutathione S-transferase alpha-4 (LOC688925), mRNA","P14942",118,{"v":4e-32,"d":"4.00E-32"},"Glutathione S-transferase alpha-4",".",".",".",".","pfam02798","GST_N","Glutathione S-transferase, N-terminal domain. Function: conjugation of reduced glutathione to a variety of targets. Also included in the alignment, but are not GSTs: * S-crystallins from squid. Similarity to GST previously noted. * Eukaryotic elongation factors 1-gamma. Not known to have GST activity; similarity not previously recognized. * HSP26 family of stress-related proteins. including auxin-regulated proteins in plants and stringent starvation proteins in Escherichia coli. Not known to have GST activity. Similarity not previously recognized. The glutathione molecule binds in a cleft between N and C-terminal domains - the catalytically important residues are proposed to reside in the N-terminal domain.",".",".",".",".","."]
["ENSRNOG00000032946",445,28.62704499,152,9.813402668,2.917137507,1.544553393,{"v":2.79427e-34,"d":"2.79E-34"},{"v":6.61922e-34,"d":"6.62E-34"},"up","yes","Pdzd7","protein_coding","chr1:243888281-243906839:-","gi|569006117|ref|XP_006526603.1|",2242,0,"PREDICTED: PDZ domain-containing protein 7 isoform X4 [Mus musculus]","gi|755562629|ref|XR_877655.1|",2499,0,"PREDICTED: Mus musculus PDZ domain containing 7 (Pdzd7), transcript variant X10, misc_RNA","Q9H5P4",769,0,"PDZ domain-containing protein 7",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.","GO:0007605|sensory perception of sound;GO:0045184|establishment of protein localization;GO:0050910|detection of mechanical stimulus involved in sensory perception of sound;GO:0060088|auditory receptor cell stereocilium organization;GO:0060117|auditory receptor cell development;","GO:0001917|photoreceptor inner segment;GO:0002141|stereocilia ankle link;GO:0002142|stereocilia ankle link complex;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0005929|cilium;GO:0032391|photoreceptor connecting cilium;GO:0032420|stereocilium;GO:0032426|stereocilium tip;GO:1990696|USH2 complex;","GO:0042802|identical protein binding;","K21882","PDZD7; PDZ domain-containing protein 7"]
["ENSRNOG00000018644",470,30.23530595,167,10.78183056,2.804283166,1.487632035,{"v":2.94735e-34,"d":"2.95E-34"},{"v":6.97895e-34,"d":"6.98E-34"},"up","yes","Slc6a7","protein_coding","chr18:54448464-54467319:-","gi|205235|gb|AAA41541.1|",3136,0,"high affinity L-proline transporter [Rattus norvegicus]","gi|132814550|ref|NM_053996.2|",2721,0,"Rattus norvegicus solute carrier family 6 member 7 (Slc6a7), mRNA","P28573",1163,0,"Sodium-dependent proline transporter","VC2012",214,{"v":3e-59,"d":"3.00E-59"},"COG0733","pfam00209","SNF","Sodium:neurotransmitter symporter family.","GO:0006836|neurotransmitter transport;GO:0015824|proline transport;GO:0035524|proline transmembrane transport;GO:0035725|sodium ion transmembrane transport;GO:0055085|transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;GO:0030285|integral component of synaptic vesicle membrane;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098978|glutamatergic synapse;GO:0099056|integral component of presynaptic membrane;","GO:0015193|L-proline transmembrane transporter activity;GO:0015293|symporter activity;","K05040","SLC6A7, PROT; solute carrier family 6 (neurotransmitter transporter, L-proline) member 7"]
["ENSRNOG00000003510",345,22.19400117,96,6.197938527,3.580868232,1.840309432,{"v":4.59023e-34,"d":"4.59E-34"},{"v":1.08197E-33,"d":"1.08E-33"},"up","yes","Fmo2","protein_coding","chr13:75224402-75244308:-","gi|78214354|ref|NP_653338.2|",2873,0,"dimethylaniline monooxygenase [N-oxide-forming] 2 [Rattus norvegicus]","gi|78214353|ref|NM_144737.2|",2010,0,"Rattus norvegicus flavin containing monooxygenase 2 (Fmo2), mRNA","Q6IRI9",1106,0,"Dimethylaniline monooxygenase [N-oxide-forming] 2","CC0774",241,{"v":1E-70,"d":"1.00E-70"},"COG2072","pfam00743","FMO-like","Flavin-binding monooxygenase-like. This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.","GO:0006082|organic acid metabolic process;GO:0006739|NADP metabolic process;GO:0006805|xenobiotic metabolic process;GO:0009404|toxin metabolic process;GO:0070995|NADPH oxidation;GO:0072592|oxygen metabolic process;","GO:0005789|endoplasmic reticulum membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0004497|monooxygenase activity;GO:0004499|N,N-dimethylaniline monooxygenase activity;GO:0050660|flavin adenine dinucleotide binding;GO:0050661|NADP binding;","K00485","FMO; dimethylaniline monooxygenase (N-oxide forming) / hypotaurine monooxygenase [EC:1.14.13.8 1.8.1.-]"]
["ENSRNOG00000033658",508,32.6798626,191,12.33131519,2.650152241,1.406075239,{"v":4.8806e-34,"d":"4.88E-34"},{"v":1.14994E-33,"d":"1.15E-33"},"up","yes","Kntc1","protein_coding","chr12:32769020-32839561:-","gi|672072960|ref|XP_008767450.1|",11399,0,"PREDICTED: kinetochore-associated protein 1 isoform X1 [Rattus norvegicus]","gi|672072959|ref|XM_008769228.1|",6944,0,"PREDICTED: Rattus norvegicus kinetochore associated 1 (Kntc1), transcript variant X1, mRNA","Q8C3Y4",4054,0,"Kinetochore-associated protein 1",".",".",".",".","pfam10493","Rod_C","Rough deal protein C-terminal region. Rod, the Rough deal protein, displays a dynamic intracellular staining pattern, localizing first to kinetochores in pro-metaphase, but moving to kinetochore microtubules at metaphase. Early in anaphase the protein is once again restricted to the kinetochores, where it persists until the end of telophase. This behaviour is in all respects similar to that described for ZW10, and indeed the two proteins function together, localisation of each depending upon the other. These two proteins are found at the kinetochore in complex with a third, Zwilch, in both flies and humans. The C-terminus is the most conserved part of the protein. During pro-metaphase, the ZW10-Rod complex, dynein/dynactin, and Mad2 all accumulate on unattached kinetochores; microtubule capture leads to Mad2 depletion as it is carried off by dynein/dynactin; ZW10-Rod complex accumulation continues, replenishing kinetochore dynein. The continuing recruitment of the ZW10-Rod complex during metaphase may serve to maintain adequate dynein/dynactin complex on kinetochores for assisting chromatid movement during anaphase. The ZW10-Rod complex acts as a bridge whose association with Zwint-1 links Mad1 and Mad2, components that are directly responsible for generating the diffusible 'wait anaphase' signal, to a structural, inner kinetochore complex containing Mis12 and KNL-1AF15q14, the last of which has been proved to be essential for kinetochore assembly in C. elegans. Removal of ZW10 or Rod inactivates the mitotic checkpoint.","GO:0000070|mitotic sister chromatid segregation;GO:0007094|mitotic spindle assembly checkpoint;GO:1903394|protein localization to kinetochore involved in kinetochore assembly;","GO:0000922|spindle pole;GO:0005737|cytoplasm;GO:0005828|kinetochore microtubule;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0015629|actin cytoskeleton;GO:1990423|RZZ complex;","GO:0031267|small GTPase binding;","K11577","KNTC1, ROD; kinetochore-associated protein 1"]
["ENSRNOG00000019982",837,53.84457676,410,26.47036246,2.034145805,1.024423094,{"v":5.54464E-34,"d":"5.54E-34"},{"v":1.30425e-33,"d":"1.30E-33"},"up","yes","Ethe1","protein_coding","chr1:80183894-80199052:+","gi|157819563|ref|NP_001099704.1|",1349,0,"persulfide dioxygenase ETHE1, mitochondrial [Rattus norvegicus]","gi|157819562|ref|NM_001106234.1|",927,0,"Rattus norvegicus ethylmalonic encephalopathy 1 (Ethe1), mRNA","Q9DCM0",512,0,"Persulfide dioxygenase ETHE1, mitochondrial","slr1259",228,{"v":7E-72,"d":"7.00E-72"},"COG0491","pfam00753","Lactamase_B","Metallo-beta-lactamase superfamily.","GO:0006749|glutathione metabolic process;GO:0070813|hydrogen sulfide metabolic process;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005739|mitochondrion;","GO:0005506|iron ion binding;GO:0016788|hydrolase activity, acting on ester bonds;GO:0042802|identical protein binding;GO:0050313|sulfur dioxygenase activity;","K17725","ETHE1; sulfur dioxygenase [EC:1.13.11.18]"]
["ENSRNOG00000066565",577,37.11866283,235,15.17203702,2.446518077,1.290729943,{"v":6.49683E-34,"d":"6.50E-34"},{"v":1.52509E-33,"d":"1.53E-33"},"up","yes","ENSRNOG00000066565","protein_coding","chr7:112482229-112484632:+","gi|670998015|ref|XP_008689893.1|",299,{"v":8e-27,"d":"8.00E-27"},"PREDICTED: protein SREK1IP1 [Ursus maritimus]","gi|672060390|ref|XM_006242128.2|",2254,0,"PREDICTED: Rattus norvegicus CG3918-like (LOC100362980), transcript variant X2, mRNA","Q5RJP9",106,{"v":8e-25,"d":"8.00E-25"},"Protein SREK1IP1",".",".",".",".","pfam13917","zf-CCHC_3","Zinc knuckle. The zinc knuckle is a zinc binding motif composed of the the following CX2CX4HX4C where X can be any amino acid. The motifs are mostly from retroviral gag proteins (nucleocapsid). Prototype structure is from HIV. Also contains members involved in eukaryotic gene regulation, such as C. elegans GLH-1. Structure is an 18-residue zinc finger.",".",".",".",".","."]
["ENSRNOG00000004736",681,43.8090284,305,19.69136719,2.224783478,1.153664936,{"v":1.49518e-33,"d":"1.50E-33"},{"v":3.47698e-33,"d":"3.48E-33"},"up","yes","Ralgps2","protein_coding","chr13:68928474-69056549:-","gi|524937446|ref|XP_005071372.1|",2837,0,"PREDICTED: ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1 [Mesocricetus auratus]","gi|880889145|ref|XM_005071315.2|",1987,0,"PREDICTED: Mesocricetus auratus Ral GEF with PH domain and SH3 binding motif 2 (Ralgps2), transcript variant X1, mRNA","Q86X27",1092,0,"Ras-specific guanine nucleotide-releasing factor RalGPS2",".",".",".",".","pfam00617","RasGEF","RasGEF domain. Guanine nucleotide exchange factor for Ras-like small GTPases.","GO:0007264|small GTPase mediated signal transduction;GO:0032485|regulation of Ral protein signal transduction;GO:0050790|regulation of catalytic activity;",".","GO:0005085|guanyl-nucleotide exchange factor activity;","K24023","RALGPS; Ras-specific guanine nucleotide-releasing factor RalGPS"]
["ENSRNOG00000036897",193,12.41577457,25,1.614046491,7.692327722,2.943420228,{"v":2.66731e-33,"d":"2.67E-33"},{"v":6.16504e-33,"d":"6.17E-33"},"up","yes","Defb24","protein_coding","chr3:141046564-141052753:-","gi|82775357|ref|NP_001032597.1|",296,{"v":5e-32,"d":"5.00E-32"},"beta-defensin 119 precursor [Rattus norvegicus]","gi|82775356|ref|NM_001037508.1|",240,{"v":4e-121,"d":"4.00E-121"},"Rattus norvegicus defensin beta 24 (Defb24), mRNA","Q8K3I8",107,{"v":3e-29,"d":"3.00E-29"},"Beta-defensin 19",".",".",".",".","pfam13841","Defensin_beta_2","Beta defensin. The beta defensins are antimicrobial peptides implicated in the resistance of epithelial surfaces to microbial colonisation.","GO:0045087|innate immune response;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:0061760|antifungal innate immune response;",".","GO:0001530|lipopolysaccharide binding;","K25606","DEFB; defensin, beta"]
["ENSRNOG00000011260",331,21.29337504,91,5.875129229,3.62432454,1.857712147,{"v":3.76316e-33,"d":"3.76E-33"},{"v":8.68037e-33,"d":"8.68E-33"},"up","yes","Cmbl","protein_coding","chr2:82571888-82591009:+","gi|56912206|ref|NP_001008770.1|",1324,{"v":3e-177,"d":"3.00E-177"},"carboxymethylenebutenolidase homolog [Rattus norvegicus]","gi|672041568|ref|XM_006232097.2|",1113,0,"PREDICTED: Rattus norvegicus carboxymethylenebutenolidase homolog (Pseudomonas) (Cmbl), transcript variant X1, mRNA","Q7TP52",514,{"v":9e-179,"d":"9.00E-179"},"Carboxymethylenebutenolidase homolog","aq_1997",100,{"v":7e-23,"d":"7.00E-23"},"COG0412","pfam01738","DLH","Dienelactone hydrolase family.",".","GO:0005829|cytosol;","GO:0016787|hydrolase activity;","K01061","E3.1.1.45; carboxymethylenebutenolidase [EC:3.1.1.45]"]
["ENSRNOG00000009409",234,15.05332254,43,2.776159965,5.42235416,2.438919346,{"v":4.95816e-33,"d":"4.96E-33"},{"v":1.14138E-32,"d":"1.14E-32"},"up","yes","Fbxo2","protein_coding","chr5:158592925-158598355:+","gi|672054666|ref|XP_008762520.1|",1223,{"v":5e-164,"d":"5.00E-164"},"PREDICTED: F-box only protein 2 isoform X1 [Rattus norvegicus]","gi|672054665|ref|XM_008764298.1|",1201,0,"PREDICTED: Rattus norvegicus F-box protein 2 (Fbxo2), transcript variant X1, mRNA","Q80UW2",455,{"v":1e-157,"d":"1.00E-157"},"F-box only protein 2",".",".",".",".","pfam04300","FBA","F-box associated region. Members of this family are associated with F-box domains, hence the name FBA. This domain is probably involved in binding other proteins that will be targeted for ubiquitination. Human FBXO2 is involved in binding to N-glycosylated proteins.","GO:0006511|ubiquitin-dependent protein catabolic process;GO:0006516|glycoprotein catabolic process;GO:0008285|negative regulation of cell proliferation;GO:0016567|protein ubiquitination;GO:0030433|ubiquitin-dependent ERAD pathway;GO:0031146|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0031396|regulation of protein ubiquitination;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0019005|SCF ubiquitin ligase complex;GO:0043197|dendritic spine;","GO:0001540|amyloid-beta binding;GO:0030246|carbohydrate binding;GO:0061630|ubiquitin protein ligase activity;","K10099","FBXO2, NFB42; F-box protein 2"]
["ENSRNOG00000057042",743,47.79751557,350,22.59665088,2.115247778,1.080826669,{"v":5.5554E-33,"d":"5.56E-33"},{"v":1.27475e-32,"d":"1.27E-32"},"up","yes","Pcca","protein_coding","chr15:99627982-99968266:+","gi|149050263|gb|EDM02587.1|",3779,0,"rCG36968, isoform CRA_b [Rattus norvegicus]","gi|158303307|ref|NM_019330.1|",2116,0,"Rattus norvegicus propionyl-CoA carboxylase alpha subunit (Pcca), mRNA","P14882",1407,0,"Propionyl-CoA carboxylase alpha chain, mitochondrial","BMEI0800",674,0,"COG4770","pfam02786","CPSase_L_D2","Carbamoyl-phosphate synthase L chain, ATP binding domain. Carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from glutamine or ammonia and bicarbonate. This important enzyme initiates both the urea cycle and the biosynthesis of arginine and/or pyrimidines. The carbamoyl-phosphate synthase (CPS) enzyme in prokaryotes is a heterodimer of a small and large chain. The small chain promotes the hydrolysis of glutamine to ammonia, which is used by the large chain to synthesize carbamoyl phosphate. See pfam00988. The small chain has a GATase domain in the carboxyl terminus. See pfam00117. The ATP binding domain (this one) has an ATP-grasp fold.","GO:0009062|fatty acid catabolic process;GO:0009063|cellular amino acid catabolic process;GO:0016042|lipid catabolic process;","GO:0005739|mitochondrion;GO:0005759|mitochondrial matrix;","GO:0004658|propionyl-CoA carboxylase activity;GO:0005524|ATP binding;GO:0019899|enzyme binding;GO:0046872|metal ion binding;","K01965","PCCA, pccA; propionyl-CoA carboxylase alpha chain [EC:6.4.1.3]"]
["ENSRNOG00000016815",792,50.94970704,385,24.85631597,2.049769045,1.035461365,{"v":8.652E-33,"d":"8.65E-33"},{"v":1.97578e-32,"d":"1.98E-32"},"up","yes","Tmem135","protein_coding","chr1:143006344-143221171:-","gi|62078521|ref|NP_001013918.1|",2359,0,"transmembrane protein 135 [Rattus norvegicus]","gi|62078520|ref|NM_001013896.1|",3395,0,"Rattus norvegicus transmembrane protein 135 (Tmem135), mRNA","Q5U4F4",913,0,"Transmembrane protein 135",".",".",".",".","pfam02466","Tim17","Tim17/Tim22/Tim23/Pmp24 family. The pre-protein translocase of the mitochondrial outer membrane (Tom) allows the import of pre-proteins from the cytoplasm. Tom forms a complex with a number of proteins, including Tim17. Tim17 and Tim23 are thought to form the translocation channel of the inner membrane. This family includes Tim17, Tim22 and Tim23. This family also includes Pmp24 a peroxisomal protein. The involvement of this domain in the targeting of PMP24 remains to be proved. PMP24 was known as Pmp27 in.","GO:0007031|peroxisome organization;GO:0009409|response to cold;GO:0032094|response to food;GO:0090140|regulation of mitochondrial fission;","GO:0005739|mitochondrion;GO:0005777|peroxisome;GO:0005778|peroxisomal membrane;GO:0005811|lipid droplet;GO:0016021|integral component of membrane;GO:0031966|mitochondrial membrane;",".",".","."]
["ENSRNOG00000016888",329,21.16471416,91,5.875129229,3.602425298,1.848968514,{"v":9.23199e-33,"d":"9.23E-33"},{"v":2.1057e-32,"d":"2.11E-32"},"up","yes","Pask","protein_coding","chr9:93844278-93885111:-","gi|57164121|ref|NP_001009362.1|",6941,0,"PAS domain-containing serine/threonine-protein kinase [Rattus norvegicus]","gi|57164120|ref|NM_001009362.1|",4530,0,"Rattus norvegicus PAS domain containing serine/threonine kinase (Pask), mRNA","Q8CEE6",2323,0,"PAS domain-containing serine/threonine-protein kinase","YAL017w_2",184,{"v":9e-50,"d":"9.00E-50"},"COG0515","pfam00069","Pkinase","Protein kinase domain.","GO:0006468|protein phosphorylation;GO:0035556|intracellular signal transduction;GO:0043576|regulation of respiratory gaseous exchange;GO:0045719|negative regulation of glycogen biosynthetic process;GO:0046777|protein autophosphorylation;GO:0070092|regulation of glucagon secretion;GO:0097009|energy homeostasis;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;GO:0035091|phosphatidylinositol binding;","K08801","PASK; PAS domain containing serine/threonine kinase [EC:2.7.11.1]"]
["ENSRNOG00000068250",306,19.68511408,80,5.164948772,3.811289318,1.930279128,{"v":2.60056e-32,"d":"2.60E-32"},{"v":5.87525e-32,"d":"5.88E-32"},"up","yes","ENSRNOG00000068250","lncRNA","chr9:105766167-105772713:-","gi|377837122|ref|XP_003688804.1|",541,{"v":3e-55,"d":"3.00E-55"},"PREDICTED: sperm motility kinase W [Mus musculus]","gi|186965653|gb|AC103346.5|",330,{"v":7e-170,"d":"7.00E-170"},"Rattus norvegicus BAC CH230-2K7 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q8C0V7",208,{"v":2E-55,"d":"2.00E-55"},"Putative sperm motility kinase W",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.",".",".",".",".","."]
["ENSRNOG00000064337",181,11.64380931,22,1.420360912,8.197782134,3.035233649,{"v":3.16616e-32,"d":"3.17E-32"},{"v":7.14174e-32,"d":"7.14E-32"},"up","yes","ENSRNOG00000064337","lncRNA","chr17:66032603-66038403:+","gi|148705016|gb|EDL36963.1|",140,4e-07,"mCG1051106 [Mus musculus]","gi|240851455|gb|AC139609.2|",2206,0,"Rattus norvegicus CH230-381A11 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam10325","7TM_GPCR_Srz","Serpentine type 7TM GPCR chemoreceptor Srz. Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srz is a solo families amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srz appear to be under strong adaptive evolutionary pressure.",".",".",".",".","."]
["ENSRNOG00000031916",620,39.88487167,271,17.49626397,2.279622195,1.188794745,{"v":4.05509e-32,"d":"4.06E-32"},{"v":9.12525e-32,"d":"9.13E-32"},"up","yes","Timeless","protein_coding","chr7:654822-678738:+","gi|149029710|gb|EDL84881.1|",5336,0,"timeless homolog (Drosophila) [Rattus norvegicus]","gi|13786173|ref|NM_031340.1|",2147,0,"Rattus norvegicus timeless circadian clock (Timeless), mRNA","Q9Z2Y1",2050,0,"Protein timeless homolog",".",".",".",".","pfam05029","TIMELESS_C","Timeless protein C terminal region. The timeless (tim) gene is essential for circadian function in Drosophila. Putative homologues of Drosophila tim have been identified in both mice and humans (mTim and hTIM, respectively). Mammalian TIM is not the true orthologue of Drosophila TIM, but is the likely orthologue of a fly gene, timeout (also called tim-2). mTim has been shown to be essential for embryonic development, but does not have substantiated circadian function. Some family members contain a SANT domain in this region.","GO:0000076|DNA replication checkpoint;GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001658|branching involved in ureteric bud morphogenesis;GO:0001822|kidney development;GO:0002009|morphogenesis of an epithelium;GO:0006281|DNA repair;GO:0006974|cellular response to DNA damage stimulus;GO:0007623|circadian rhythm;GO:0030324|lung development;GO:0042752|regulation of circadian rhythm;GO:0042753|positive regulation of circadian rhythm;GO:0043111|replication fork arrest;GO:0044770|cell cycle phase transition;GO:0045892|negative regulation of transcription, DNA-templated;GO:0048478|replication fork protection;GO:0048754|branching morphogenesis of an epithelial tube;GO:0051301|cell division;GO:0072711|cellular response to hydroxyurea;GO:0072719|cellular response to cisplatin;GO:1904976|cellular response to bleomycin;GO:1905168|positive regulation of double-strand break repair via homologous recombination;GO:2000781|positive regulation of double-strand break repair;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0031298|replication fork protection complex;GO:0035861|site of double-strand break;","GO:0003677|DNA binding;GO:0005515|protein binding;GO:0042802|identical protein binding;","K03155","TIMELESS; timeless"]
["ENSRNOG00000042309",344,22.12967074,102,6.585309685,3.360460145,1.748658793,{"v":8.91693e-32,"d":"8.92E-32"},{"v":1.9948E-31,"d":"1.99E-31"},"up","yes","Kiaa0408L","protein_coding","chr1:28615606-28630309:-","gi|242117994|ref|NP_001138331.2|",3217,0,"uncharacterized protein KIAA0408 homolog [Rattus norvegicus]","gi|242117993|ref|NM_001144859.2|",4152,0,"Rattus norvegicus SOGA family member 3 (Soga3), mRNA",".",".",".",".",".",".",".",".","pfam14818","DUF4482","Domain of unknown function (DUF4482). This family is found in eukaryotes, and is approximately 140 amino acids in length. The family is found in association with pfam11365.",".",".",".",".","."]
["ENSRNOG00000006365",145,9.327913537,0,0.03228093,288.9604973,8.174728471,{"v":1.40942e-31,"d":"1.41E-31"},{"v":3.14315e-31,"d":"3.14E-31"},"up","yes","Asb15","protein_coding","chr4:53031692-53049928:+","gi|672018077|ref|XP_008773902.1|",3250,0,"PREDICTED: ankyrin repeat and SOCS box protein 15 isoform X2 [Rattus norvegicus]","gi|672018076|ref|XM_008775680.1|",1974,0,"PREDICTED: Rattus norvegicus ankyrin repeat and SOCS box containing 15 (Asb15), transcript variant X2, mRNA","Q8VHS6",1165,0,"Ankyrin repeat and SOCS box protein 15","all2748",108,{"v":4e-24,"d":"4.00E-24"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0016567|protein ubiquitination;GO:0035556|intracellular signal transduction;GO:0036371|protein localization to T-tubule;GO:0055117|regulation of cardiac muscle contraction;","GO:0030315|T-tubule;",".","K10337","ASB15; ankyrin repeat and SOCS box protein 15"]
["ENSRNOG00000031167",240,15.43930516,49,3.163531123,4.880402488,2.287000132,{"v":1.75255E-31,"d":"1.75E-31"},{"v":3.89923E-31,"d":"3.90E-31"},"up","yes","ENSRNOG00000031167","protein_coding","chr3:140599608-140628448:+","gi|672047421|ref|XP_008760530.1|",1186,{"v":2e-162,"d":"2.00E-162"},"PREDICTED: sulfiredoxin-1 isoform X1 [Rattus norvegicus]","gi|672047420|ref|XM_008762308.1|",767,0,"PREDICTED: Rattus norvegicus sulfiredoxin 1 (Srxn1), transcript variant X1, mRNA","Q9BYN0",179,{"v":9e-55,"d":"9.00E-55"},"Sulfiredoxin-1","SPBC106.02c",67.8,{"v":2e-13,"d":"2.00E-13"},"COG5119","pfam02195","ParBc","ParB-like nuclease domain.","GO:0006979|response to oxidative stress;GO:0098869|cellular oxidant detoxification;","GO:0005829|cytosol;","GO:0005524|ATP binding;GO:0016667|oxidoreductase activity, acting on a sulfur group of donors;","K12260","SRX1; sulfiredoxin [EC:1.8.98.2]"]
["ENSRNOG00000025245",553,35.57473232,231,14.91378958,2.385358337,1.254206009,{"v":3.1978e-31,"d":"3.20E-31"},{"v":7.07891e-31,"d":"7.08E-31"},"up","yes","RGD1311946","protein_coding","chr1:200945180-200962585:+","gi|71043854|ref|NP_001020854.1|",868,{"v":1e-104,"d":"1.00E-104"},"uncharacterized protein C11orf24 homolog precursor [Rattus norvegicus]","gi|71043853|ref|NM_001025683.1|",2067,0,"Rattus norvegicus similar to RIKEN cDNA 1810055G02 (RGD1311946), mRNA","Q4V7A5",338,{"v":3e-106,"d":"3.00E-106"},"Uncharacterized protein C11orf24 homolog",".",".",".",".","pfam05109","Herpes_BLLF1","Herpes virus major outer envelope glycoprotein (BLLF1). This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralizing antibodies in vivo.",".","GO:0005654|nucleoplasm;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;",".",".","."]
["ENSRNOG00000068016",420,27.01878404,148,9.555155229,2.827665631,1.499611533,{"v":3.85582e-31,"d":"3.86E-31"},{"v":8.51906e-31,"d":"8.52E-31"},"up","yes","ENSRNOG00000068016","protein_coding","chr19:21909754-22356833:-","gi|672083970|ref|XP_008770468.1|",1034,{"v":2E-125,"d":"2.00E-125"},"PREDICTED: LOW QUALITY PROTEIN: disks large homolog 5-like isoform X2 [Rattus norvegicus]","gi|425703057|gb|AC246664.5|",2331,0,"Rattus norvegicus Y Chr BAC RNAEX-360A21 (Amplicon Express Rat SHR-Akr BAC library) complete sequence","P11260",79,{"v":7e-14,"d":"7.00E-14"},"LINE-1 retrotransposable element ORF1 protein",".",".",".",".","pfam02994","Transposase_22","L1 transposable element.",".",".",".",".","."]
["ENSRNOG00000007947",526,33.83781049,214,13.81623797,2.449133445,1.292271384,{"v":4.0429e-31,"d":"4.04E-31"},{"v":8.92205e-31,"d":"8.92E-31"},"up","yes","Fam13a","protein_coding","chr4:88058403-88155860:-","gi|625289810|ref|XP_007636654.1|",3180,0,"PREDICTED: LOW QUALITY PROTEIN: protein FAM13A [Cricetulus griseus]","gi|672049861|ref|XM_006236586.2|",2397,0,"PREDICTED: Rattus norvegicus family with sequence similarity 13, member A (Fam13a), transcript variant X2, mRNA","Q8BGI4",1109,0,"Protein FAM13A",".",".",".",".","pfam13687","DUF4153","Domain of unknown function (DUF4153). Members of this family are annotated as putative inner membrane proteins.",".",".",".",".","."]
["ENSRNOG00000019305",793,51.01403748,395,25.50193456,2.000398729,1.000287593,{"v":4.18153e-31,"d":"4.18E-31"},{"v":9.21729e-31,"d":"9.22E-31"},"up","yes","Sh3tc2","protein_coding","chr18:55416413-55483083:+","gi|564320705|ref|XP_001059165.2|",6378,0,"PREDICTED: SH3 domain and tetratricopeptide repeat-containing protein 2 isoform X2 [Rattus norvegicus]","gi|672030743|ref|XM_001059165.5|",4647,0,"PREDICTED: Rattus norvegicus SH3 domain and tetratricopeptide repeats 2 (Sh3tc2), transcript variant X2, mRNA","Q80VA5",2277,0,"SH3 domain and tetratricopeptide repeat-containing protein 2",".",".",".",".","pfam00018","SH3_1","SH3 domain. SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta barrel.","GO:0022011|myelination in peripheral nervous system;GO:0032287|peripheral nervous system myelin maintenance;GO:0033157|regulation of intracellular protein transport;GO:1901184|regulation of ERBB signaling pathway;","GO:0005886|plasma membrane;GO:0031410|cytoplasmic vesicle;GO:0055037|recycling endosome;",".","K24313","SH3TC; SH3 domain and tetratricopeptide repeat-containing protein"]
["ENSRNOG00000020125",672,43.23005446,314,20.27242393,2.132456119,1.092516055,{"v":1.72603E-30,"d":"1.73E-30"},{"v":3.75824e-30,"d":"3.76E-30"},"up","yes","Cd79a","protein_coding","chr1:80493581-80497935:+","gi|392337482|ref|XP_003753271.1|",965,{"v":5e-128,"d":"5.00E-128"},"PREDICTED: B-cell antigen receptor complex-associated protein alpha chain isoform X1 [Rattus norvegicus]","gi|298904658|emb|FQ225076.1|",996,0,"Rattus norvegicus TL0AEA55YD17 mRNA sequence","P11911",339,{"v":5e-115,"d":"5.00E-115"},"B-cell antigen receptor complex-associated protein alpha chain",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0002250|adaptive immune response;GO:0030183|B cell differentiation;GO:0042100|B cell proliferation;GO:0042113|B cell activation;GO:0050853|B cell receptor signaling pathway;","GO:0005771|multivesicular body;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0019815|B cell receptor complex;GO:0045121|membrane raft;","GO:0004888|transmembrane signaling receptor activity;GO:0042802|identical protein binding;","K06506","CD79A, IGA; CD79A antigen"]
["ENSRNOG00000048411",598,38.46960203,265,17.10889281,2.248514995,1.168972505,{"v":2.90665e-30,"d":"2.91E-30"},{"v":6.30489e-30,"d":"6.30E-30"},"up","yes","Uhrf1","protein_coding","chr9:1134909-1154631:+","gi|57114344|ref|NP_001008882.1|",4040,0,"E3 ubiquitin-protein ligase UHRF1 [Rattus norvegicus]","gi|71051853|gb|BC099224.1|",2269,0,"Rattus norvegicus ubiquitin-like, containing PHD and RING finger domains, 1, mRNA (cDNA clone IMAGE:7388089), partial cds","Q7TPK1",1538,0,"E3 ubiquitin-protein ligase UHRF1","DR1533",120,{"v":2e-28,"d":"2.00E-28"},"COG3440","pfam02182","SAD_SRA","SAD/SRA domain. The domain goes by several names including SAD, SRA and YDG. It adopts a beta barrel, modified PUA-like, fold that is widely present in eukaryotic chromatin proteins and in bacteria. Versions of this domain are known to bind hemi-methylated CpG dinucleotides and also other 5mC containing dinucleotides. The domain binds DNA by flipping out the methylated cytosine base from the DNA double helix.The conserved tyrosine and aspartate residues and a glycine rich patch are critical for recognition of the flipped out base. Mammalian UHRF1 that contains this domain plays an important role in maintenance of methylation at CpG dinucleotides by recruiting DNMT1 to hemimethylated sites associated with replication forks. The SAD/SRA domain has been combined with other domains involved in the ubiquitin pathway on multiple occasions and such proteins link recognition of DNA methylation to chromatin-protein ubiquitination. The domain is also found in species that lack DNA methylation, such as certain apicomplexans, suggestive of other DNA-binding modes or functions. A highly derived and distinct version of the domain is also found in fungi where it is fused to AlkB-type 2OGFeDO domains. In bacteria, the domain is usually fused or associated with restriction endonucleases, many of which target methylated or hemi-methylated DNA.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006281|DNA repair;GO:0006511|ubiquitin-dependent protein catabolic process;GO:0010216|maintenance of DNA methylation;GO:0010390|histone monoubiquitination;GO:0016567|protein ubiquitination;GO:0016574|histone ubiquitination;GO:0032270|positive regulation of cellular protein metabolic process;GO:0043434|response to peptide hormone;GO:0050678|regulation of epithelial cell proliferation;GO:0051865|protein autoubiquitination;","GO:0000785|chromatin;GO:0000791|euchromatin;GO:0000792|heterochromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005657|replication fork;GO:0005886|plasma membrane;GO:0016363|nuclear matrix;GO:0031410|cytoplasmic vesicle;","GO:0000987|proximal promoter sequence-specific DNA binding;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0004842|ubiquitin-protein transferase activity;GO:0008270|zinc ion binding;GO:0008327|methyl-CpG binding;GO:0016740|transferase activity;GO:0031493|nucleosomal histone binding;GO:0035064|methylated histone binding;GO:0042393|histone binding;GO:0042802|identical protein binding;GO:0044729|hemi-methylated DNA-binding;GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;","K10638","UHRF1, NP95; E3 ubiquitin-protein ligase UHRF1 [EC:2.3.2.27]"]
["ENSRNOG00000010934",270,17.36921831,67,4.325644597,4.015405778,2.005545787,{"v":4.18111e-30,"d":"4.18E-30"},{"v":9.02138e-30,"d":"9.02E-30"},"up","yes","Spa17","protein_coding","chr8:37307557-37318639:-","gi|16758238|ref|NP_445934.1|",586,{"v":1E-73,"d":"1.00E-73"},"sperm surface protein Sp17 [Rattus norvegicus]","gi|672061334|ref|XM_006242812.2|",666,0,"PREDICTED: Rattus norvegicus sperm autoantigenic protein 17 (Spa17), transcript variant X1, mRNA","Q62252",210,{"v":3e-67,"d":"3.00E-67"},"Sperm surface protein Sp17",".",".",".",".","pfam02197","RIIa","Regulatory subunit of type II PKA R-subunit.","GO:0007339|binding of sperm to zona pellucida;","GO:0005737|cytoplasm;GO:0005929|cilium;GO:0009897|external side of plasma membrane;GO:0031514|motile cilium;GO:0035686|sperm fibrous sheath;GO:0097228|sperm principal piece;","GO:0005516|calmodulin binding;","K25633","SPA17; sperm surface protein Sp17"]
["ENSRNOG00000022321",250,16.08260955,57,3.680026,4.370243456,2.127713651,{"v":4.47517e-30,"d":"4.48E-30"},{"v":9.65221e-30,"d":"9.65E-30"},"up","yes","Hapln3","protein_coding","chr1:133046467-133080177:-","gi|564328981|ref|XP_006229459.1|",2541,0,"PREDICTED: hyaluronan and proteoglycan link protein 3 isoform X1 [Rattus norvegicus]","gi|672037089|ref|XM_006229397.2|",2194,0,"PREDICTED: Rattus norvegicus hyaluronan and proteoglycan link protein 3 (Hapln3), transcript variant X1, mRNA","P70490",860,0,"Lactadherin",".",".",".",".","pfam00193","Xlink","Extracellular link domain.","GO:0001501|skeletal system development;GO:0007155|cell adhesion;GO:0007417|central nervous system development;","GO:0005576|extracellular region;GO:0031012|extracellular matrix;","GO:0005540|hyaluronic acid binding;","K06852","HAPLN3; hyaluronan and proteoglycan link protein 3"]
["ENSRNOG00000065526",207,13.3164007,37,2.388788807,5.574540815,2.478852973,{"v":6.1787e-30,"d":"6.18E-30"},{"v":1.32913E-29,"d":"1.33E-29"},"up","yes","ENSRNOG00000065526","protein_coding","chr7:7330105-7345177:-","gi|15284007|dbj|BAB63448.1|",1817,0,"gonadotropin inducible ovarian transcription factor 2 beta [Rattus norvegicus]","gi|15284006|dbj|AB047638.1|",1034,0,"Rattus norvegicus GIOT2 beta mRNA for gonadotropin inducible ovarian transcription factor 2 beta, complete cds","E9QAG8",347,{"v":1E-107,"d":"1.00E-107"},"Zinc finger protein 431",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000013202",579,37.24732371,254,16.39871235,2.271356611,1.183554232,{"v":6.60639e-30,"d":"6.61E-30"},{"v":1.419e-29,"d":"1.42E-29"},"up","yes","Akap7","protein_coding","chr1:20087373-20217797:+","gi|49169847|ref|NP_001001801.1|",1831,0,"A-kinase anchor protein 7 isoforms delta and gamma [Rattus norvegicus]","gi|68534165|gb|BC098632.1|",3013,0,"Rattus norvegicus A kinase (PRKA) anchor protein 7, mRNA (cDNA clone MGC:112559 IMAGE:7315112), complete cds","Q6JP77",707,0,"A-kinase anchor protein 7 isoforms delta and gamma",".",".",".",".","pfam10469","AKAP7_NLS","AKAP7 2'5' RNA ligase-like domain. AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes. AKAP7_NLS carries the nuclear localisation signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein. Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains pfam02834. Presumably this domain carried out some as yet unknown enzymatic function.","GO:0008104|protein localization;GO:0010738|regulation of protein kinase A signaling;GO:0050804|modulation of chemical synaptic transmission;GO:0060306|regulation of membrane repolarization;GO:0071320|cellular response to cAMP;GO:1901381|positive regulation of potassium ion transmembrane transport;GO:1902261|positive regulation of delayed rectifier potassium channel activity;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016020|membrane;GO:0016324|apical plasma membrane;GO:0016328|lateral plasma membrane;GO:0016529|sarcoplasmic reticulum;GO:0030315|T-tubule;GO:0032991|protein-containing complex;GO:0070382|exocytic vesicle;GO:0098686|hippocampal mossy fiber to CA3 synapse;","GO:0005515|protein binding;GO:0008022|protein C-terminus binding;GO:0016208|AMP binding;GO:0019901|protein kinase binding;GO:0019904|protein domain specific binding;GO:0034237|protein kinase A regulatory subunit binding;GO:0051018|protein kinase A binding;","K16524","AKAP7; A-kinase anchor protein 7"]
["ENSRNOG00000003244",232,14.92466166,49,3.163531123,4.717722405,2.238090532,{"v":9.65648e-30,"d":"9.66E-30"},{"v":2.06869e-29,"d":"2.07E-29"},"up","yes","Ltc4s","protein_coding","chr10:34560360-34562651:-","gi|148701763|gb|EDL33710.1|",574,{"v":4E-70,"d":"4.00E-70"},"leukotriene C4 synthase, isoform CRA_b [Mus musculus]","gi|672067209|ref|XM_008767655.1|",776,0,"PREDICTED: Rattus norvegicus leukotriene C4 synthase (Ltc4s), transcript variant X1, mRNA","Q925U2",220,{"v":3e-70,"d":"3.00E-70"},"Leukotriene C4 synthase",".",".",".",".","pfam01124","MAPEG","MAPEG family. This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolizm). It includes proteins such as Prostaglandin E synthase. This enzyme catalyses the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.","GO:0006691|leukotriene metabolic process;GO:0009410|response to xenobiotic stimulus;GO:0010035|response to inorganic substance;GO:0019370|leukotriene biosynthetic process;GO:0032496|response to lipopolysaccharide;GO:0042759|long-chain fatty acid biosynthetic process;GO:0048678|response to axon injury;GO:0050790|regulation of catalytic activity;GO:0071222|cellular response to lipopolysaccharide;GO:0071299|cellular response to vitamin A;GO:0098869|cellular oxidant detoxification;","GO:0005635|nuclear envelope;GO:0005640|nuclear outer membrane;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0031965|nuclear membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0004364|glutathione transferase activity;GO:0004464|leukotriene-C4 synthase activity;GO:0004602|glutathione peroxidase activity;GO:0008047|enzyme activator activity;GO:0008289|lipid binding;GO:0042802|identical protein binding;GO:0043295|glutathione binding;GO:0044877|protein-containing complex binding;","K00807","LTC4S; leukotriene-C4 synthase [EC:4.4.1.20]"]
["ENSRNOG00000001692",264,16.98323568,65,4.196520878,4.046979909,2.016845687,{"v":1.11922E-29,"d":"1.12E-29"},{"v":2.39408E-29,"d":"2.39E-29"},"up","yes","Chaf1b","protein_coding","chr11:33200981-33221070:+","gi|67078530|ref|NP_001019912.1|",2789,0,"chromatin assembly factor 1 subunit B [Rattus norvegicus]","gi|67078529|ref|NM_001024741.1|",1933,0,"Rattus norvegicus chromatin assembly factor 1 subunit B (Chaf1b), mRNA","Q9D0N7",1015,0,"Chromatin assembly factor 1 subunit B",".",".",".",".","pfam15512","CAF-1_p60_C","Chromatin assembly factor complex 1 subunit p60, C-terminal. CAF-1_p60_C is a family of vertebral proteins that is involved in chromatin assembly. CAF-1_p60 is one of the three subunits of the CAF-1 complex, and this domain binds to the C-terminal region of CAF-1_p150, family pfam12253. The N-terminal part of the CAF-1_p60 proteins is a WD-repeat structure, pfam00400.","GO:0006334|nucleosome assembly;GO:0006335|DNA replication-dependent nucleosome assembly;GO:0031497|chromatin assembly;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0032991|protein-containing complex;GO:0033186|CAF-1 complex;",".","K10751","CHAF1B; chromatin assembly factor 1 subunit B"]
["ENSRNOG00000053675",398,25.6035144,140,9.038660352,2.832666944,1.502160984,{"v":1.14655e-29,"d":"1.15E-29"},{"v":2.45164e-29,"d":"2.45E-29"},"up","yes","Dhh","protein_coding","chr7:130050910-130056406:-","gi|444515377|gb|ELV10876.1|",1691,0,"Protein LMBR1L [Tupaia chinensis]","gi|274327781|ref|NM_053367.1|",2479,0,"Rattus norvegicus desert hedgehog (Dhh), mRNA","Q61488",653,0,"Desert hedgehog protein",".",".",".",".","pfam01085","HH_signal","Hedgehog amino-terminal signalling domain. For the carboxyl Hint module, see pfam01079. Hedgehog is a family of secreted signal molecules required for embryonic cell differentiation.","GO:0001649|osteoblast differentiation;GO:0001708|cell fate specification;GO:0007224|smoothened signaling pathway;GO:0007267|cell-cell signaling;GO:0007286|spermatid development;GO:0010468|regulation of gene expression;GO:0016539|intein-mediated protein splicing;GO:0016540|protein autoprocessing;GO:0030238|male sex determination;GO:0032355|response to estradiol;GO:0033327|Leydig cell differentiation;GO:0042552|myelination;GO:0043627|response to estrogen;GO:0050810|regulation of steroid biosynthetic process;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005886|plasma membrane;","GO:0003674|molecular_function;GO:0005113|patched binding;GO:0005509|calcium ion binding;GO:0008233|peptidase activity;GO:0008270|zinc ion binding;","K11990","DHH; desert hedgehog"]
["ENSRNOG00000003832",494,31.77923646,201,12.97693379,2.448901796,1.292134921,{"v":2.5281e-29,"d":"2.53E-29"},{"v":5.3596e-29,"d":"5.36E-29"},"up","yes","Vash2","protein_coding","chr13:102529719-102560391:-","gi|564382294|ref|XP_006250525.1|",1948,0,"PREDICTED: vasohibin-2 isoform X2 [Rattus norvegicus]","gi|672075185|ref|XM_006250463.2|",3656,0,"PREDICTED: Rattus norvegicus vasohibin 2 (Vash2), transcript variant X3, mRNA","Q8C5G2",635,0,"Vasohibin-2",".",".",".",".","pfam14822","Vasohibin","Vasohibin. This family of proteins function as angiogenesis inhibitors in animals.","GO:0000768|syncytium formation by plasma membrane fusion;GO:0001938|positive regulation of endothelial cell proliferation;GO:0006508|proteolysis;GO:0045765|regulation of angiogenesis;GO:0045766|positive regulation of angiogenesis;GO:0060674|placenta blood vessel development;GO:0060711|labyrinthine layer development;GO:0060716|labyrinthine layer blood vessel development;GO:0061564|axon development;GO:0140253|cell-cell fusion;","GO:0005737|cytoplasm;","GO:0003779|actin binding;GO:0004181|metallocarboxypeptidase activity;GO:0008017|microtubule binding;","K23355","VASH; tubulinyl-Tyr carboxypeptidase [EC:3.4.17.17]"]
["ENSRNOG00000061215",680,43.74469797,326,21.04716625,2.078412716,1.055482163,{"v":3.06168E-29,"d":"3.06E-29"},{"v":6.47638e-29,"d":"6.48E-29"},"up","yes","Crym","protein_coding","chr1:174560416-174575633:-","gi|16758840|ref|NP_446407.1|",1592,0,"ketimine reductase mu-crystallin [Rattus norvegicus]","gi|56789443|gb|BC088121.1|",732,0,"Rattus norvegicus crystallin, mu, mRNA (cDNA clone MGC:108623 IMAGE:7323247), complete cds","Q9QYU4",617,0,"Ketimine reductase mu-crystallin","MA3252",139,{"v":5E-36,"d":"5.00E-36"},"COG2423","pfam02423","OCD_Mu_crystall","Ornithine cyclodeaminase/mu-crystallin family. This family contains the bacterial Ornithine cyclodeaminase enzyme EC:4.3.1.12, which catalyses the deamination of ornithine to proline. This family also contains mu-Crystallin the major component of the eye lens in several Australian marsupials, mRNA for this protein has also been found in human retina.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006839|mitochondrial transport;GO:0007605|sensory perception of sound;GO:0009725|response to hormone;GO:0033280|response to vitamin D;GO:0042403|thyroid hormone metabolic process;GO:0070327|thyroid hormone transport;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;","GO:0003674|molecular_function;GO:0003714|transcription corepressor activity;GO:0042562|hormone binding;GO:0042803|protein homodimerization activity;GO:0047127|thiomorpholine-carboxylate dehydrogenase activity;GO:0050661|NADP binding;GO:0070324|thyroid hormone binding;","K18258","CRYM; thiomorpholine-carboxylate dehydrogenase [EC:1.5.1.25]"]
["ENSRNOG00000014075",279,17.94819225,74,4.777577614,3.756755767,1.909487327,{"v":3.30468e-29,"d":"3.30E-29"},{"v":6.98005E-29,"d":"6.98E-29"},"up","yes","Clybl","protein_coding","chr15:99283650-99505695:+","gi|213512607|ref|NP_001094155.1|",1794,0,"citrate lyase subunit beta-like protein, mitochondrial precursor [Rattus norvegicus]","gi|213512606|ref|NM_001100685.1|",1225,0,"Rattus norvegicus citrate lyase beta like (Clybl), mRNA","Q5I0K3",695,0,"Citramalyl-CoA lyase, mitochondrial","VNG0627G",158,{"v":2e-43,"d":"2.00E-43"},"COG2301","pfam03328","HpcH_HpaI","HpcH/HpaI aldolase/citrate lyase family. This family includes 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase and 4-hydroxy-2-oxovalerate aldolase.","GO:0070207|protein homotrimerization;GO:0106064|regulation of cobalamin metabolic process;GO:0106121|positive regulation of cobalamin metabolic process;","GO:0005739|mitochondrion;","GO:0000287|magnesium ion binding;GO:0004474|malate synthase activity;GO:0016787|hydrolase activity;GO:0047777|(3S)-citramalyl-CoA lyase activity;","K11390","CLYBL; citrate lyase subunit beta-like protein [EC:4.1.-.-]"]
["ENSRNOG00000014844",542,34.8670975,233,15.0429133,2.317842083,1.212782277,{"v":3.82493e-29,"d":"3.82E-29"},{"v":8.06698e-29,"d":"8.07E-29"},"up","yes","Kif21a","protein_coding","chr7:122062537-122178999:-","gi|672022268|ref|XP_008774783.1|",7979,0,"PREDICTED: kinesin-like protein KIF21A isoform X2 [Rattus norvegicus]","gi|672060488|ref|XM_008765828.1|",6312,0,"PREDICTED: Rattus norvegicus kinesin family member 21A (Kif21a), transcript variant X16, mRNA","Q9QXL2",2936,0,"Kinesin-like protein KIF21A","ECU05g0060_1",252,{"v":8e-71,"d":"8.00E-71"},"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0007018|microtubule-based movement;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005829|cytosol;GO:0005871|kinesin complex;GO:0005874|microtubule;GO:0005886|plasma membrane;","GO:0003674|molecular_function;GO:0003777|microtubule motor activity;GO:0005524|ATP binding;GO:0008017|microtubule binding;GO:0016887|ATPase activity;GO:0071532|ankyrin repeat binding;","K24185","KIF21; kinesin family member 21"]
["ENSRNOG00000046890",485,31.20026252,196,12.65412449,2.465620007,1.301950474,{"v":3.8567e-29,"d":"3.86E-29"},{"v":8.13098e-29,"d":"8.13E-29"},"up","yes","Abca6","protein_coding","chr10:95142966-95211530:-","gi|564313554|ref|XP_006220946.1|",8247,0,"PREDICTED: ATP-binding cassette sub-family A member 6 isoform X1 [Rattus norvegicus]","gi|672025392|ref|XM_008775463.1|",5670,0,"PREDICTED: Rattus norvegicus ATP-binding cassette, subfamily A (ABC1), member 6 (Abca6), transcript variant X3, mRNA","Q8K441",2669,0,"ATP-binding cassette sub-family A member 6","PAB1703",155,{"v":7e-40,"d":"7.00E-40"},"COG1131","pfam00005","ABC_tran","ABC transporter. ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide or belong in different polypeptide chains.","GO:0006869|lipid transport;GO:0008150|biological_process;GO:0055085|transmembrane transport;","GO:0000139|Golgi membrane;GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0003674|molecular_function;GO:0005319|lipid transporter activity;GO:0005524|ATP binding;GO:0042626|ATPase activity, coupled to transmembrane movement of substances;","K05649","ABCA6; ATP-binding cassette, subfamily A (ABC1), member 6"]
["ENSRNOG00000015075",406,26.1181579,147,9.490593369,2.752004736,1.460482953,{"v":4.64261e-29,"d":"4.64E-29"},{"v":9.76265e-29,"d":"9.76E-29"},"up","yes","Stc1","protein_coding","chr15:44299621-44310264:+","gi|803011834|ref|XP_004004231.2|",1291,{"v":4e-168,"d":"4.00E-168"},"PREDICTED: stanniocalcin-1 [Ovis aries]","gi|51036665|ref|NM_031123.2|",2434,0,"Rattus norvegicus stanniocalcin 1 (Stc1), mRNA","P97574",485,{"v":4E-165,"d":"4.00E-165"},"Stanniocalcin-1",".",".",".",".","pfam03298","Stanniocalcin","Stanniocalcin family.","GO:0001503|ossification;GO:0001886|endothelial cell morphogenesis;GO:0003421|growth plate cartilage axis specification;GO:0006874|cellular calcium ion homeostasis;GO:0007165|signal transduction;GO:0007566|embryo implantation;GO:0010596|negative regulation of endothelial cell migration;GO:0014070|response to organic cyclic compound;GO:0030336|negative regulation of cell migration;GO:0033280|response to vitamin D;GO:0035988|chondrocyte proliferation;GO:0044070|regulation of anion transport;GO:0046697|decidualization;GO:0051926|negative regulation of calcium ion transport;GO:0060348|bone development;GO:0071320|cellular response to cAMP;GO:0071385|cellular response to glucocorticoid stimulus;GO:0071456|cellular response to hypoxia;GO:0086004|regulation of cardiac muscle cell contraction;GO:0090280|positive regulation of calcium ion import;GO:1903403|negative regulation of renal phosphate excretion;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0016324|apical plasma membrane;","GO:0003674|molecular_function;GO:0005179|hormone activity;GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000015156",207,13.3164007,39,2.517912527,5.288666927,2.402904119,{"v":6.13987e-29,"d":"6.14E-29"},{"v":1.28922E-28,"d":"1.29E-28"},"up","yes","Gal","protein_coding","chr1:200650439-200654959:-","gi|15147221|ref|NP_150240.1|",513,{"v":2e-63,"d":"2.00E-63"},"galanin peptides preproprotein [Rattus norvegicus]","gi|15147220|ref|NM_033237.1|",555,0,"Rattus norvegicus galanin/GMAP prepropeptide (Gal), mRNA","P10683",202,{"v":7e-65,"d":"7.00E-65"},"Galanin peptides",".",".",".",".","pfam06540","GMAP","Galanin message associated peptide (GMAP). This family consists of several galanin message associated peptides. In rat preprogalanin, galanin is C-terminally flanked by a 60 amino acid long peptide: galanin message-associated peptide (GMAP). GMAP sequences in different species show high degree of homology, but the biological function of this family is unknown.","GO:0006954|inflammatory response;GO:0007218|neuropeptide signaling pathway;GO:0007399|nervous system development;GO:0007631|feeding behavior;GO:0008285|negative regulation of cell proliferation;GO:0009410|response to xenobiotic stimulus;GO:0010737|protein kinase A signaling;GO:0019933|cAMP-mediated signaling;GO:0031943|regulation of glucocorticoid metabolic process;GO:0032868|response to insulin;GO:0035902|response to immobilization stress;GO:0043065|positive regulation of apoptotic process;GO:0043627|response to estrogen;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050672|negative regulation of lymphocyte proliferation;GO:0050776|regulation of immune response;GO:0051464|positive regulation of cortisol secretion;GO:0051795|positive regulation of timing of catagen;GO:0090274|positive regulation of somatostatin secretion;GO:0090275|negative regulation of somatostatin secretion;GO:1902608|positive regulation of large conductance calcium-activated potassium channel activity;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0030141|secretory granule;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0044306|neuron projection terminus;","GO:0001664|G protein-coupled receptor binding;GO:0004966|galanin receptor activity;GO:0005184|neuropeptide hormone activity;GO:0031763|galanin receptor binding;GO:0031764|type 1 galanin receptor binding;GO:0031765|type 2 galanin receptor binding;GO:0031766|type 3 galanin receptor binding;","K05244","GAL; galanin"]
["ENSRNOG00000013969",675,43.42304577,326,21.04716625,2.06313027,1.044834918,{"v":1.37753E-28,"d":"1.38E-28"},{"v":2.87031e-28,"d":"2.87E-28"},"up","yes","Ahi1","protein_coding","chr1:15762462-15891041:+","gi|50511316|ref|NP_001002277.1|",4997,0,"jouberin [Rattus norvegicus]","gi|298883929|emb|FQ226565.1|",3144,0,"Rattus norvegicus TL0AEA24YM19 mRNA sequence","Q6DTM3",1922,0,"Jouberin",".",".",".",".","pfam00018","SH3_1","SH3 domain. SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta barrel.","GO:0001738|morphogenesis of a polarized epithelium;GO:0001947|heart looping;GO:0002092|positive regulation of receptor internalization;GO:0006903|vesicle targeting;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007417|central nervous system development;GO:0010628|positive regulation of gene expression;GO:0010842|retina layer formation;GO:0010976|positive regulation of neuron projection development;GO:0016192|vesicle-mediated transport;GO:0021510|spinal cord development;GO:0030862|positive regulation of polarized epithelial cell differentiation;GO:0030902|hindbrain development;GO:0032094|response to food;GO:0033365|protein localization to organelle;GO:0034613|cellular protein localization;GO:0035844|cloaca development;GO:0035845|photoreceptor cell outer segment organization;GO:0039008|pronephric nephron tubule morphogenesis;GO:0039023|pronephric duct morphogenesis;GO:0042462|eye photoreceptor cell development;GO:0043066|negative regulation of apoptotic process;GO:0045927|positive regulation of growth;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046325|negative regulation of glucose import;GO:0046548|retinal rod cell development;GO:0046549|retinal cone cell development;GO:0050708|regulation of protein secretion;GO:0050795|regulation of behavior;GO:0060041|retina development in camera-type eye;GO:0060271|cilium assembly;GO:0065001|specification of axis polarity;GO:0070121|Kupffer's vesicle development;GO:0070986|left/right axis specification;GO:0071599|otic vesicle development;GO:1905515|non-motile cilium assembly;GO:1990403|embryonic brain development;","GO:0001750|photoreceptor outer segment;GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0005814|centriole;GO:0005911|cell-cell junction;GO:0005912|adherens junction;GO:0005929|cilium;GO:0036038|MKS complex;GO:0036064|ciliary basal body;GO:0097730|non-motile cilium;","GO:0005515|protein binding;GO:0042802|identical protein binding;","K16740","AHI1; jouberin"]
["ENSRNOG00000067370",672,43.23005446,324,20.91804253,2.066639572,1.047286801,{"v":1.43119e-28,"d":"1.43E-28"},{"v":2.98102e-28,"d":"2.98E-28"},"up","yes","ENSRNOG00000067370","protein_coding","chr16:1627605-1636979:+","gi|564318467|ref|XP_006222143.1|",806,{"v":2E-100,"d":"2.00E-100"},"PREDICTED: uncharacterized protein LOC100911661 isoform X1 [Rattus norvegicus]","gi|672029006|ref|XM_006222081.2|",1071,0,"PREDICTED: Rattus norvegicus uncharacterized LOC100911661 (LOC100911661), transcript variant X1, mRNA","E9Q9R9",48.5,{"v":2e-11,"d":"2.00E-11"},"Disks large homolog 5",".",".",".",".","pfam12484","PE_PPE_C","Polymorphic PE/PPE proteins C terminal. This domain family is found in bacteria, and is approximately 90 amino acids in length. The family is found in association with pfam00823. There is a conserved SVP sequence motif. There is a single completely conserved residue W that may be functionally important. The proteins in this family are PE/PPE proteins implicated in immunostimulation and virulence.",".",".",".",".","."]
["ENSRNOG00000069664",128,8.234296088,0,0.03228093,255.08237,7.994819381,{"v":1.5139E-28,"d":"1.51E-28"},{"v":3.14985e-28,"d":"3.15E-28"},"up","yes","ENSRNOG00000069664","protein_coding","chr11:4144721-4148339:-","gi|70778812|ref|NP_780421.2|",411,{"v":2E-45,"d":"2.00E-45"},"transmembrane protein 65 [Mus musculus]","gi|14389324|gb|AC087775.2|",371,0,"Rattus norvegicus strain Brown Norway clone RP31-464J4, complete sequence","Q4VAE3",162,{"v":7e-47,"d":"7.00E-47"},"Transmembrane protein 65",".",".",".",".","pfam10507","DUF2453","Protein of unknown function (DUF2453). Some members of this family are purported to contain GAF domains but this could not be confirmed. The function is not known. It is likely to be a transmembrane protein.",".",".",".",".","."]
["ENSRNOG00000010784",215,13.83104421,44,2.840721825,4.868848505,2.283580612,{"v":2.49776E-28,"d":"2.50E-28"},{"v":5.17802e-28,"d":"5.18E-28"},"up","yes","Scg3","protein_coding","chr8:76399777-76442015:-","gi|149019137|gb|EDL77778.1|",2470,0,"secretogranin III, isoform CRA_a [Rattus norvegicus]","gi|402692420|ref|NM_053856.2|",2132,0,"Rattus norvegicus secretogranin III (Scg3), mRNA","P47868",953,0,"Secretogranin-3",".",".",".",".","pfam15467","SGIII","Secretogranin-3. Secretogranin_3 is a family of vertebrate proteins that is one of the granin family. Granins are rich in acidic amino acids, exhibit aggregation at low pH, and possess a high capacity for calcium binding. Because granins are restricted in their localisation to secretory granules of neuroendocrine cells, two interesting characteristics of their sorting mechanisms have been observed. These are, first, that they aggregate on low pH/high calcium concentrations and second that two of them carry an N-terminal disulfide loop, mutations in which lead to mis-sorting. Thus, granins are thought to be essential for the sorting of secretory proteins at the trans-Golgi network. Chromogranin A (CgA) binds to SGIII in secretory granules of endocrine cells. SGIII directly binds to cholesterol components of the secretory granule membrane and targets CgA to secretory granules in pituitary and pancreatic endocrine cells. Mutations in the SGIII gene may influence the risk of obesity through possible regulation of hypothalamic neuropeptide secretion.","GO:0033366|protein localization to secretory granule;","GO:0005576|extracellular region;GO:0030658|transport vesicle membrane;GO:0030667|secretory granule membrane;GO:0031410|cytoplasmic vesicle;","GO:0005515|protein binding;",".","."]
["ENSRNOG00000009790",259,16.66158349,66,4.261082737,3.910176009,1.967233549,{"v":2.89446e-28,"d":"2.89E-28"},{"v":5.98087e-28,"d":"5.98E-28"},"up","yes","Kcnk3","protein_coding","chr6:25763228-25799153:-","gi|15431283|ref|NP_203694.1|",1909,0,"potassium channel subfamily K member 3 [Rattus norvegicus]","gi|15431282|ref|NM_033376.1|",2011,0,"Rattus norvegicus potassium two pore domain channel subfamily K member 3 (Kcnk3), mRNA","O54912",739,0,"Potassium channel subfamily K member 3","YJL093c",56.2,2e-07,"COG1226","pfam07885","Ion_trans_2","Ion channel. This family includes the two membrane helix type ion channels found in bacteria.","GO:0006813|potassium ion transport;GO:0007420|brain development;GO:0009410|response to xenobiotic stimulus;GO:0030322|stabilization of membrane potential;GO:0034220|ion transmembrane transport;GO:0051481|negative regulation of cytosolic calcium ion concentration;GO:0071294|cellular response to zinc ion;GO:0071456|cellular response to hypoxia;GO:0071805|potassium ion transmembrane transport;GO:0090102|cochlea development;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;","GO:0005216|ion channel activity;GO:0005252|open rectifier potassium channel activity;GO:0005515|protein binding;GO:0008022|protein C-terminus binding;GO:0022841|potassium ion leak channel activity;GO:0044548|S100 protein binding;","K04914","KCNK3, K2P3.1; potassium channel subfamily K member 3"]
["ENSRNOG00000018964",699,44.96697629,346,22.33840344,2.012989711,1.009339798,{"v":5.27277e-28,"d":"5.27E-28"},{"v":1.08442e-27,"d":"1.08E-27"},"up","yes","Gss","protein_coding","chr3:144047850-144078198:-","gi|149030883|gb|EDL85910.1|",2475,0,"glutathione synthetase, isoform CRA_c [Rattus norvegicus]","gi|672047404|ref|XM_008762303.1|",1844,0,"PREDICTED: Rattus norvegicus glutathione synthetase (Gss), transcript variant X1, mRNA","P46413",954,0,"Glutathione synthetase",".",".",".",".","pfam03917","GSH_synth_ATP","Eukaryotic glutathione synthase, ATP binding domain.","GO:0006750|glutathione biosynthetic process;GO:0007568|aging;GO:0009410|response to xenobiotic stimulus;GO:0031667|response to nutrient levels;GO:0034612|response to tumor necrosis factor;GO:0043200|response to amino acid;GO:0046686|response to cadmium ion;","GO:0005829|cytosol;","GO:0000287|magnesium ion binding;GO:0004363|glutathione synthase activity;GO:0005524|ATP binding;GO:0016594|glycine binding;GO:0042277|peptide binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0043295|glutathione binding;","K21456","GSS; glutathione synthase [EC:6.3.2.3]"]
["ENSRNOG00000007454",293,18.84881839,85,5.487758071,3.434702869,1.780185299,{"v":5.88506e-28,"d":"5.89E-28"},{"v":1.20991e-27,"d":"1.21E-27"},"up","yes","Aloxe3","protein_coding","chr10:53831264-53854328:+","gi|157786622|ref|NP_001099263.1|",3760,0,"hydroperoxide isomerase ALOXE3 [Rattus norvegicus]","gi|672067783|ref|XM_006246617.2|",2517,0,"PREDICTED: Rattus norvegicus arachidonate lipoxygenase 3 (Aloxe3), transcript variant X1, mRNA","D3ZKX9",1452,0,"Hydroperoxide isomerase ALOXE3",".",".",".",".","pfam00305","Lipoxygenase","Lipoxygenase.","GO:0006665|sphingolipid metabolic process;GO:0008150|biological_process;GO:0019233|sensory perception of pain;GO:0019369|arachidonic acid metabolic process;GO:0019372|lipoxygenase pathway;GO:0035357|peroxisome proliferator activated receptor signaling pathway;GO:0043651|linoleic acid metabolic process;GO:0045444|fat cell differentiation;GO:0046513|ceramide biosynthetic process;GO:0051122|hepoxilin biosynthetic process;GO:0061436|establishment of skin barrier;","GO:0005575|cellular_component;GO:0005737|cytoplasm;","GO:0003674|molecular_function;GO:0005506|iron ion binding;GO:0016702|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;GO:0050486|intramolecular transferase activity, transferring hydroxy groups;GO:0051120|hepoxilin A3 synthase activity;","K18684","ALOXE3; hydroperoxy icosatetraenoate dehydratase/isomerase [EC:4.2.1.152 5.4.4.7]"]
["ENSRNOG00000067687",430,27.66208842,167,10.78183056,2.565620769,1.359307938,{"v":1.07509E-27,"d":"1.08E-27"},{"v":2.19763e-27,"d":"2.20E-27"},"up","yes","ENSRNOG00000067687","lncRNA","chr18:2174748-2187554:-","gi|5764030|emb|CAB53342.1|",291,{"v":7e-28,"d":"7.00E-28"},"GATA-6 [Homo sapiens]","gi|564392645|ref|XR_361202.1|",1337,0,"PREDICTED: Rattus norvegicus uncharacterized LOC100909782 (LOC100909782), ncRNA","P39017",58.2,6e-08,"40S ribosomal protein S6",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSRNOG00000011323",203,13.05907895,40,2.582474386,5.056808703,2.338227203,{"v":1.45194E-27,"d":"1.45E-27"},{"v":2.9616e-27,"d":"2.96E-27"},"up","yes","Lgi3","protein_coding","chr15:45605611-45612739:+","gi|157822677|ref|NP_001100747.1|",2702,0,"leucine-rich repeat LGI family member 3 precursor [Rattus norvegicus]","gi|157822676|ref|NM_001107277.1|",3319,0,"Rattus norvegicus leucine-rich repeat LGI family, member 3 (Lgi3), mRNA","Q8K406",1030,0,"Leucine-rich repeat LGI family member 3",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.","GO:0017157|regulation of exocytosis;","GO:0005576|extracellular region;GO:0008021|synaptic vesicle;","GO:0003824|catalytic activity;","K19999","LGI3; leucine-rich repeat LGI family member 3"]
["ENSRNOG00000027350",468,30.10664507,192,12.39587705,2.428762801,1.2802216,{"v":1.7122e-27,"d":"1.71E-27"},{"v":3.485e-27,"d":"3.49E-27"},"up","yes","Tns4","protein_coding","chr10:84021966-84041346:-","gi|149054153|gb|EDM05970.1|",3378,0,"tensin 4 [Rattus norvegicus]","gi|67846031|ref|NM_001024881.1|",2467,0,"Rattus norvegicus tensin 4 (Tns4), mRNA","Q4V8I3",1304,0,"Tensin-4",".",".",".",".","pfam08416","PTB","Phosphotyrosine-binding domain. The phosphotyrosine-binding domain (PTB, also phosphotyrosine-interaction or PI domain) in the protein tensin tends to be found at the C-terminus. Tensin is a multi-domain protein that binds to actin filaments and functions as a focal-adhesion molecule (focal adhesions are regions of plasma membrane through which cells attach to the extracellular matrix). Human tensin has actin-binding sites, an SH2 (pfam00017) domain and a region similar to the tumor suppressor PTEN. The PTB domain interacts with the cytoplasmic tails of beta integrin by binding to an NPXY motif.","GO:0006915|apoptotic process;GO:0008104|protein localization;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005925|focal adhesion;","GO:0003779|actin binding;","K18080","TNS; tensin"]
["ENSRNOG00000057470",581,37.37598459,267,17.23801653,2.168230001,1.116517802,{"v":1.77578e-27,"d":"1.78E-27"},{"v":3.61313e-27,"d":"3.61E-27"},"up","yes","Pla2g12a","protein_coding","chr2:218436513-218452740:+","gi|672044253|ref|XP_008759737.1|",819,{"v":6e-104,"d":"6.00E-104"},"PREDICTED: group XIIA secretory phospholipase A2 isoform X1 [Rattus norvegicus]","gi|672044252|ref|XM_008761515.1|",1501,0,"PREDICTED: Rattus norvegicus phospholipase A2, group XIIA (Pla2g12a), transcript variant X1, mRNA","Q9EPR2",314,{"v":2e-103,"d":"2.00E-103"},"Group XIIA secretory phospholipase A2",".",".",".",".","pfam06951","PLA2G12","Group XII secretory phospholipase A2 precursor (PLA2G12). This family consists of several group XII secretory phospholipase A2 precursor (PLA2G12) (EC:3.1.1.4) proteins. Group XII and group V PLA(2)s are thought to participate in helper T cell immune response through release of immediate second signals and generation of downstream eicosanoids.","GO:0006644|phospholipid metabolic process;GO:0016042|lipid catabolic process;GO:0050482|arachidonic acid secretion;","GO:0005576|extracellular region;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;","GO:0004623|phospholipase A2 activity;GO:0005509|calcium ion binding;","K01047","PLA2G, SPLA2; secretory phospholipase A2 [EC:3.1.1.4]"]
["ENSRNOG00000005719",488,31.39325383,206,13.29974309,2.360440621,1.239056191,{"v":2.96169e-27,"d":"2.96E-27"},{"v":5.99614e-27,"d":"6.00E-27"},"up","yes","Emc4","protein_coding","chr3:99169711-99174729:-","gi|507689725|ref|XP_004712730.1|",842,{"v":6e-108,"d":"6.00E-108"},"PREDICTED: ER membrane protein complex subunit 4 [Echinops telfairi]","gi|157817407|ref|NM_001106495.1|",1423,0,"Rattus norvegicus ER membrane protein complex subunit 4 (Emc4), mRNA","Q9CZX9",328,{"v":3e-109,"d":"3.00E-109"},"ER membrane protein complex subunit 4",".",".",".",".","pfam06417","DUF1077","Protein of unknown function (DUF1077). This family consists of several hypothetical eukaryotic proteins of unknown function.","GO:0045050|protein insertion into ER membrane by stop-transfer membrane-anchor sequence;GO:0071816|tail-anchored membrane protein insertion into ER membrane;","GO:0016021|integral component of membrane;GO:0030176|integral component of endoplasmic reticulum membrane;GO:0072546|ER membrane protein complex;","GO:0032977|membrane insertase activity;","K23565","EMC4, TMEM85; ER membrane protein complex subunit 4"]
["ENSRNOG00000070506",400,25.73217527,151,9.748840808,2.639511279,1.400270831,{"v":5.35538E-27,"d":"5.36E-27"},{"v":1.07736e-26,"d":"1.08E-26"},"up","yes","Chst8","pseudogene","chr1:87294540-87435900:-","gi|157819451|ref|NP_001100974.1|",2062,0,"carbohydrate sulfotransferase 8 [Rattus norvegicus]","gi|172353768|ref|NM_001107504.2|",1646,0,"Rattus norvegicus carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 (Chst8), mRNA","Q8BQ86",772,0,"Carbohydrate sulfotransferase 8",".",".",".",".","pfam03567","Sulfotransfer_2","Sulfotransferase family. This family includes a variety of sulfotransferase enzymes. Chondroitin 6-sulfotransferase catalyses the transfer of sulfate to position 6 of the N-acetylgalactosamine residue of chondroitin. This family also includes Heparan sulfate 2-O-sulfotransferase (HS2ST) and Heparan sulfate 6-sulfotransferase (HS6ST). Heparan sulfate (HS) is a co-receptor for a number of growth factors, morphogens, and adhesion proteins. HS biosynthetic modifications may determine the strength and outcome of HS-ligand interactions. Mice that lack HS2ST undergo developmental failure only after midgestation,the most dramatic effect being the complete failure of kidney development. Heparan sulphate 6- O -sulfotransferase (HS6ST) catalyses the transfer of sulphate from adenosine 3'-phosphate, 5'-phosphosulphate to the 6th position of the N -sulphoglucosamine residue in heparan sulphate.",".",".",".",".","."]
["ENSRNOG00000007805",293,18.84881839,88,5.68144365,3.317610725,1.730144616,{"v":6.2117E-27,"d":"6.21E-27"},{"v":1.24568E-26,"d":"1.25E-26"},"up","yes","Mybl2","protein_coding","chr3:151705288-151733708:+","gi|157817067|ref|NP_001100006.1|",3408,0,"myb-related protein B [Rattus norvegicus]","gi|157817066|ref|NM_001106536.1|",3710,0,"Rattus norvegicus myeloblastosis oncogene-like 2 (Mybl2), mRNA","P48972",1206,0,"Myb-related protein B","ECU11g1690",146,{"v":4e-38,"d":"4.00E-38"},"COG5147","pfam09316","Cmyb_C","C-myb, C-terminal. Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumorigenesis.","GO:0000278|mitotic cell cycle;GO:0006355|regulation of transcription, DNA-templated;GO:0043525|positive regulation of neuron apoptotic process;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0090307|mitotic spindle assembly;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0031523|Myb complex;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837|sequence-specific double-stranded DNA binding;","K21769","MYBL2, B-MYB; myb-related protein B"]
["ENSRNOG00000009974",419,26.9544536,164,10.58814498,2.545720109,1.34807381,{"v":1.04275E-26,"d":"1.04E-26"},{"v":2.08087e-26,"d":"2.08E-26"},"up","yes","Coq3","protein_coding","chr5:35429574-35460607:+","gi|57015268|sp|Q63159.2|COQ3_RAT",1862,0,"RecName: Full=Ubiquinone biosynthesis O-methyltransferase, mitochondrial; AltName: Full=3-demethylubiquinol 3-O-methyltransferase; AltName: Full=Polyprenyldihydroxybenzoate methyltransferase; Flags: Precursor","gi|298901212|emb|FQ216025.1|",1234,0,"Rattus norvegicus TL0ACA45YD23 mRNA sequence","Q63159",721,0,"Ubiquinone biosynthesis O-methyltransferase, mitochondrial","AGl2640",199,{"v":1E-59,"d":"1.00E-59"},"COG2227","pfam08241","Methyltransf_11","Methyltransferase domain. Members of this family are SAM dependent methyltransferases.","GO:0006071|glycerol metabolic process;GO:0006744|ubiquinone biosynthetic process;GO:0010795|regulation of ubiquinone biosynthetic process;GO:0032259|methylation;","GO:0005739|mitochondrion;GO:0031314|extrinsic component of mitochondrial inner membrane;","GO:0004395|hexaprenyldihydroxybenzoate methyltransferase activity;GO:0008171|O-methyltransferase activity;GO:0008425|2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity;GO:0008689|3-demethylubiquinone-9 3-O-methyltransferase activity;","K00591","COQ3; polyprenyldihydroxybenzoate methyltransferase / 3-demethylubiquinol 3-O-methyltransferase [EC:2.1.1.114 2.1.1.64]"]
["ENSRNOG00000046468",284,18.26984444,84,5.423196211,3.368833384,1.752249077,{"v":1.35378e-26,"d":"1.35E-26"},{"v":2.69779e-26,"d":"2.70E-26"},"up","yes","Ptgfr","protein_coding","chr2:240733375-240765650:-","gi|6981436|ref|NP_037247.1|",1826,0,"prostaglandin F2-alpha receptor [Rattus norvegicus]","gi|6981435|ref|NM_013115.1|",2979,0,"Rattus norvegicus prostaglandin F receptor (Ptgfr), mRNA","P43118",707,0,"Prostaglandin F2-alpha receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0006954|inflammatory response;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0008284|positive regulation of cell proliferation;GO:0010628|positive regulation of gene expression;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0035584|calcium-mediated signaling using intracellular calcium source;GO:0043066|negative regulation of apoptotic process;GO:0071799|cellular response to prostaglandin D stimulus;","GO:0005576|extracellular region;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004958|prostaglandin F receptor activity;","K04262","PTGFR; prostaglandin F receptor"]
["ENSRNOG00000070740",407,26.18248834,157,10.13621197,2.583064406,1.369083616,{"v":1.42369e-26,"d":"1.42E-26"},{"v":2.83512e-26,"d":"2.84E-26"},"up","yes","ENSRNOG00000070740","lncRNA","chr8:20499124-20500415:+","gi|68062262|ref|XP_673136.1|",126,4e-06,"hypothetical protein [Plasmodium berghei strain ANKA], partial [Plasmodium berghei ANKA]","gi|354787999|gb|JN952500.1|",102,{"v":7e-44,"d":"7.00E-44"},"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Memo1:tm1a(EUCOMM)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.",".",".",".",".","."]
["ENSRNOG00000021805",666,42.84407183,331,21.36997555,2.004872291,1.003510341,{"v":1.60463e-26,"d":"1.60E-26"},{"v":3.18877e-26,"d":"3.19E-26"},"up","yes","Rft1","protein_coding","chr16:5827088-5861120:+","gi|578806701|ref|XP_006713447.1|",1179,{"v":1E-179,"d":"1.00E-179"},"PREDICTED: protein RFT1 homolog isoform X3 [Homo sapiens]","gi|209529742|ref|NM_001135866.1|",1295,0,"Rattus norvegicus RFT1 homolog (Rft1), mRNA","Q8C3B8",482,{"v":3E-160,"d":"3.00E-160"},"Protein RFT1 homolog",".",".",".",".","pfam04506","Rft-1","Rft protein.","GO:0006488|dolichol-linked oligosaccharide biosynthetic process;GO:0034203|glycolipid translocation;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;",".","K06316","RFT1; oligosaccharide translocation protein RFT1"]
["ENSRNOG00000023440",254,16.3399313,68,4.390206457,3.721904986,1.896041226,{"v":1.67763e-26,"d":"1.68E-26"},{"v":3.33268e-26,"d":"3.33E-26"},"up","yes","Phex","protein_coding","chrX:37610760-37854469:+","gi|149042404|gb|EDL96111.1|",3958,0,"phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets), isoform CRA_a [Rattus norvegicus]","gi|6981355|ref|NM_013004.1|",4165,0,"Rattus norvegicus phosphate regulating endopeptidase homolog, X-linked (Phex), mRNA","P70669",1521,0,"Metalloendopeptidase homolog PEX","MA2001",296,{"v":2E-85,"d":"2.00E-85"},"COG3590","pfam05649","Peptidase_M13_N","Peptidase family M13. M13 peptidases are well-studied proteases found in a wide range of organisms including mammals and bacteria. In mammals they participate in processes such as cardiovascular development, blood-pressure regulation, nervous control of respiration, and regulation of the function of neuropeptides in the central nervous system. In bacteria they may be used for digestion of milk.","GO:0006508|proteolysis;GO:0016485|protein processing;GO:0019637|organophosphate metabolic process;GO:0030282|bone mineralization;GO:0030324|lung development;GO:0033280|response to vitamin D;GO:0042476|odontogenesis;GO:0060348|bone development;GO:0060416|response to growth hormone;GO:0071305|cellular response to vitamin D;GO:0071374|cellular response to parathyroid hormone stimulus;GO:1904383|response to sodium phosphate;GO:1990418|response to insulin-like growth factor stimulus;","GO:0005575|cellular_component;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0048471|perinuclear region of cytoplasm;","GO:0003674|molecular_function;GO:0004222|metalloendopeptidase activity;GO:0046872|metal ion binding;","K08636","PHEX; phosphate-regulating neutral endopeptidase [EC:3.4.24.-]"]
["ENSRNOG00000020689",285,18.33417488,85,5.487758071,3.340922586,1.740246554,{"v":1.9169e-26,"d":"1.92E-26"},{"v":3.80271e-26,"d":"3.80E-26"},"up","yes","Cpeb3","protein_coding","chr1:234751733-234931560:-","gi|672040273|ref|XP_008758601.1|",2998,0,"PREDICTED: cytoplasmic polyadenylation element-binding protein 3 isoform X1 [Rattus norvegicus]","gi|672014818|ref|XM_008774796.1|",4932,0,"PREDICTED: Rattus norvegicus cytoplasmic polyadenylation element binding protein 3 (Cpeb3), transcript variant X3, mRNA","Q7TN99",1144,0,"Cytoplasmic polyadenylation element-binding protein 3",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006412|translation;GO:0007616|long-term memory;GO:0017148|negative regulation of translation;GO:0045727|positive regulation of translation;GO:0048167|regulation of synaptic plasticity;GO:0050955|thermoception;GO:0060213|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening;GO:0060998|regulation of dendritic spine development;GO:0060999|positive regulation of dendritic spine development;GO:0061158|3'-UTR-mediated mRNA destabilization;GO:0071230|cellular response to amino acid stimulus;GO:1900153|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:1900248|negative regulation of cytoplasmic translational elongation;GO:1900273|positive regulation of long-term synaptic potentiation;GO:1900365|positive regulation of mRNA polyadenylation;GO:2000766|negative regulation of cytoplasmic translation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0030014|CCR4-NOT complex;GO:0030425|dendrite;GO:0030496|midbody;GO:0043005|neuron projection;GO:0045202|synapse;GO:0097440|apical dendrite;GO:0098794|postsynapse;GO:1990124|messenger ribonucleoprotein complex;","GO:0000900|translation repressor activity, mRNA regulatory element binding;GO:0003723|RNA binding;GO:0003730|mRNA 3'-UTR binding;GO:0008135|translation factor activity, RNA binding;GO:0035613|RNA stem-loop binding;GO:0035925|mRNA 3'-UTR AU-rich region binding;GO:0043022|ribosome binding;","K02602","CPEB, ORB; cytoplasmic polyadenylation element-binding protein"]
["ENSRNOG00000008480",220,14.1526964,51,3.292654842,4.298262976,2.103753752,{"v":2.61519e-26,"d":"2.62E-26"},{"v":5.17538e-26,"d":"5.18E-26"},"up","yes","Kcnab3","protein_coding","chr10:54047825-54054174:+","gi|13928902|ref|NP_113840.1|",1832,0,"voltage-gated potassium channel subunit beta-3 [Rattus norvegicus]","gi|672068038|ref|XM_008767862.1|",2105,0,"PREDICTED: Rattus norvegicus potassium voltage-gated channel, shaker-related subfamily, beta member 3 (Kcnab3), transcript variant X1, mRNA","Q63494",710,0,"Voltage-gated potassium channel subunit beta-3","TM0313",278,{"v":8e-86,"d":"8.00E-86"},"COG0667","pfam00248","Aldo_ket_red","Aldo/keto reductase family. This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.","GO:0071805|potassium ion transmembrane transport;GO:1901379|regulation of potassium ion transmembrane transport;","GO:0005737|cytoplasm;GO:0008076|voltage-gated potassium channel complex;","GO:0004033|aldo-keto reductase (NADP) activity;GO:0005249|voltage-gated potassium channel activity;GO:0015459|potassium channel regulator activity;GO:0044325|ion channel binding;GO:0047834|D-threo-aldose 1-dehydrogenase activity;","K04884","KCNAB3; potassium voltage-gated channel Shaker-related subfamily A, beta member 3"]
["ENSRNOG00000047106",410,26.37547966,160,10.32989754,2.553314739,1.352371385,{"v":2.7334e-26,"d":"2.73E-26"},{"v":5.40557e-26,"d":"5.41E-26"},"up","yes","Mtrf1","protein_coding","chr15:54776937-54804704:+","gi|109502759|ref|XP_001073018.1|",2319,0,"PREDICTED: peptide chain release factor 1, mitochondrial isoform X1 [Rattus norvegicus]","gi|672028784|ref|XM_001073018.5|",1945,0,"PREDICTED: Rattus norvegicus mitochondrial translational release factor 1 (Mtrf1), transcript variant X1, mRNA","Q8K126",815,0,"Peptide chain release factor 1, mitochondrial","PA4665",257,{"v":7e-78,"d":"7.00E-78"},"COG0216","pfam00472","RF-1","RF-1 domain. This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.","GO:0070126|mitochondrial translational termination;","GO:0005739|mitochondrion;","GO:0003747|translation release factor activity;","K02835","prfA, MTRF1, MRF1; peptide chain release factor 1"]
["ENSRNOG00000065944",622,40.01353255,302,19.49768162,2.05222002,1.037185411,{"v":3.56048e-26,"d":"3.56E-26"},{"v":7.01692e-26,"d":"7.02E-26"},"up","yes","Sc5d","protein_coding","chr8:42632672-42641273:-","gi|149041411|gb|EDL95252.1|",1433,0,"sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae), isoform CRA_b [Rattus norvegicus]","gi|52138614|ref|NM_053642.2|",1696,0,"Rattus norvegicus sterol-C5-desaturase (Sc5d), mRNA","Q9EQS5",551,0,"Lathosterol oxidase","SPAC1687.16c",219,{"v":9e-65,"d":"9.00E-65"},"COG3000","pfam04116","FA_hydroxylase","Fatty acid hydroxylase superfamily. This superfamily includes fatty acid and carotene hydroxylases and sterol desaturases. Beta-carotene hydroxylase is involved in zeaxanthin synthesis by hydroxylating beta-carotene, but the enzyme may be involved in other pathways. This family includes C-5 sterol desaturase and C-4 sterol methyl oxidase. Members of this family are involved in cholesterol biosynthesis and biosynthesis a plant cuticular wax. These enzymes contain two copies of a HXHH motif. Members of this family are integral membrane proteins.",".",".",".",".","."]
["ENSRNOG00000034075",287,18.46283576,87,5.61688179,3.287025871,1.716782811,{"v":3.79364e-26,"d":"3.79E-26"},{"v":7.46355e-26,"d":"7.46E-26"},"up","yes","Ube2ql1","protein_coding","chr1:33548814-33589174:+","gi|223555981|ref|NP_001138634.1|",1066,{"v":1E-134,"d":"1.00E-134"},"ubiquitin-conjugating enzyme E2Q-like protein 1 [Mus musculus]","gi|223555982|ref|NM_001145163.1|",2653,0,"Rattus norvegicus ubiquitin-conjugating enzyme E2Q family-like 1 (Ube2ql1), mRNA","A0PJN4",339,{"v":4E-109,"d":"4.00E-109"},"Ubiquitin-conjugating enzyme E2Q-like protein 1",".",".",".",".","pfam00179","UQ_con","Ubiquitin-conjugating enzyme. Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. TSG101 is one of several UBC homologues that lacks this active site cysteine.","GO:0000209|protein polyubiquitination;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;","GO:0061631|ubiquitin conjugating enzyme activity;","K10582","UBE2Q; ubiquitin-conjugating enzyme E2 Q [EC:2.3.2.23]"]
["ENSRNOG00000070490",448,28.82003631,185,11.94394404,2.412941338,1.270792842,{"v":4.18339E-26,"d":"4.18E-26"},{"v":8.21335e-26,"d":"8.21E-26"},"up","yes","ENSRNOG00000070490","lncRNA","chr3:56733057-56734666:-",".",".",".",".","gi|672045726|ref|XM_006234352.2|",1610,0,"PREDICTED: Rattus norvegicus pyruvate dehydrogenase kinase, isozyme 1 (Pdk1), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam00660","SRP1_TIP1","Seripauperin and TIP1 family.",".",".",".",".","."]
["ENSRNOG00000053661",153,9.842557042,21,1.355799053,7.259598701,2.859889801,{"v":4.90398e-26,"d":"4.90E-26"},{"v":9.61159e-26,"d":"9.61E-26"},"up","yes","Klra17","protein_coding","chr4:163368380-163455261:-","gi|672051537|ref|XP_008761655.1|",1409,0,"PREDICTED: killer cell lectin-like receptor 7 isoform X6 [Rattus norvegicus]","gi|672018818|ref|XM_003753951.3|",1045,0,"PREDICTED: Rattus norvegicus similar to immunoreceptor Ly49si3 (LOC690097), transcript variant X1, mRNA","Q60654",309,{"v":6e-101,"d":"6.00E-101"},"Killer cell lectin-like receptor 7",".",".",".",".","pfam08391","Ly49","Ly49-like protein, N-terminal region. The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000011841",232,14.92466166,58,3.74458786,3.985662032,1.994819381,{"v":6.25658e-26,"d":"6.26E-26"},{"v":1.22332e-25,"d":"1.22E-25"},"up","yes","Map2","protein_coding","chr9:67723371-67979809:+","gi|672065487|ref|XP_008765425.1|",7966,0,"PREDICTED: microtubule-associated protein 2 isoform X6 [Rattus norvegicus]","gi|672065486|ref|XM_008767203.1|",5426,0,"PREDICTED: Rattus norvegicus microtubule-associated protein 2 (Map2), transcript variant X7, mRNA","P15146",2900,0,"Microtubule-associated protein 2",".",".",".",".","pfam08377","MAP2_projctn","MAP2/Tau projection domain. This domain is found in the MAP2/Tau family of proteins which includes MAP2, MAP4, Tau, and their homologs. All isoforms contain a conserved C-terminal domain containing tubulin-binding repeats (pfam00418), and a N-terminal projection domain of varying size. This domain has a net negative charge and exerts a long-range repulsive force. This provides a mechanism that can regulate microtubule spacing which might facilitate efficient organelle transport.","GO:0000226|microtubule cytoskeleton organization;GO:0001578|microtubule bundle formation;GO:0007026|negative regulation of microtubule depolymerization;GO:0007409|axonogenesis;GO:0016358|dendrite development;GO:0021954|central nervous system neuron development;GO:0030010|establishment of cell polarity;GO:0030517|negative regulation of axon extension;GO:0031115|negative regulation of microtubule polymerization;GO:0031175|neuron projection development;GO:0032355|response to estradiol;GO:0032570|response to progesterone;GO:0048813|dendrite morphogenesis;GO:0071310|cellular response to organic substance;GO:1901953|positive regulation of anterograde dense core granule transport;GO:1902513|regulation of organelle transport along microtubule;GO:1903744|positive regulation of anterograde synaptic vesicle transport;GO:1903827|regulation of cellular protein localization;GO:1904527|negative regulation of microtubule binding;","GO:0005737|cytoplasm;GO:0005790|smooth endoplasmic reticulum;GO:0005791|rough endoplasmic reticulum;GO:0005874|microtubule;GO:0014069|postsynaptic density;GO:0015629|actin cytoskeleton;GO:0015630|microtubule cytoskeleton;GO:0030424|axon;GO:0030425|dendrite;GO:0032587|ruffle membrane;GO:0032839|dendrite cytoplasm;GO:0032991|protein-containing complex;GO:0034399|nuclear periphery;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043194|axon initial segment;GO:0043198|dendritic shaft;GO:0043203|axon hillock;GO:0044294|dendritic growth cone;GO:0044297|cell body;GO:0044307|dendritic branch;GO:0097440|apical dendrite;GO:0097441|basal dendrite;GO:0097442|CA3 pyramidal cell dendrite;GO:0150001|primary dendrite;GO:0150002|distal dendrite;GO:0150014|apical distal dendrite;GO:1902737|dendritic filopodium;GO:1990635|proximal dendrite;GO:1990769|proximal neuron projection;","GO:0002162|dystroglycan binding;GO:0003779|actin binding;GO:0005515|protein binding;GO:0005516|calmodulin binding;GO:0008017|microtubule binding;GO:0015631|tubulin binding;GO:0019901|protein kinase binding;","K10430","MAP2; microtubule-associated protein 2"]
["ENSRNOG00000068218",534,34.35245399,243,15.6885319,2.189653832,1.130702809,{"v":7.10423E-26,"d":"7.10E-26"},{"v":1.38669E-25,"d":"1.39E-25"},"up","yes","ENSRNOG00000068218","lncRNA","chr9:26405945-26416745:-","gi|392342270|ref|XP_003754547.1|",468,{"v":1E-50,"d":"1.00E-50"},"PREDICTED: UPF0369 protein C6orf57 homolog isoform X1 [Rattus norvegicus]","gi|672023828|ref|XM_003754499.2|",1129,0,"PREDICTED: Rattus norvegicus hypothetical protein LOC685888 (LOC685888), transcript variant X1, mRNA","Q8BTE0",155,{"v":7e-42,"d":"7.00E-42"},"Succinate dehydrogenase assembly factor 4, mitochondrial",".",".",".",".","pfam07896","DUF1674","Protein of unknown function (DUF1674). The members of this family are sequences derived from hypothetical eukaryotic and bacterial proteins. The region in question is approximately 60 residues long.",".",".",".",".","."]
["ENSRNOG00000042714",157,10.0998788,23,1.484922772,6.801618902,2.765878173,{"v":7.87198e-26,"d":"7.87E-26"},{"v":1.53392E-25,"d":"1.53E-25"},"up","yes","RGD1559459","protein_coding","chr14:21145827-21167704:+","gi|392333006|ref|XP_003752765.1|",2720,0,"PREDICTED: UDP-glucuronosyltransferase 2B31-like isoform X1 [Rattus norvegicus]","gi|672076000|ref|XM_006250809.2|",3122,0,"PREDICTED: Rattus norvegicus similar to Expressed sequence AI788959 (RGD1559459), transcript variant X4, mRNA","Q6K1J1",772,0,"UDP-glucuronosyltransferase 2B31","slr1125",72,{"v":4e-12,"d":"4.00E-12"},"COG1819","pfam00201","UDPGT","UDP-glucoronosyl and UDP-glucosyl transferase.","GO:0008202|steroid metabolic process;GO:0052697|xenobiotic glucuronidation;","GO:0005640|nuclear outer membrane;GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0008194|UDP-glycosyltransferase activity;GO:0015020|glucuronosyltransferase activity;","K00699","UGT; glucuronosyltransferase [EC:2.4.1.17]"]
["ENSRNOG00000032311",184,11.83680063,35,2.259665088,5.238298671,2.38909832,{"v":9.62265e-26,"d":"9.62E-26"},{"v":1.86995e-25,"d":"1.87E-25"},"up","yes","Ttll8","protein_coding","chr7:120001794-120045075:-","gi|295293121|ref|NP_766406.2|",3797,0,"protein monoglycylase TTLL8 [Mus musculus]","gi|672060698|ref|XR_593743.1|",2612,0,"PREDICTED: Rattus norvegicus similar to RIKEN cDNA 1700019P01 (RGD1306462), transcript variant X2, misc_RNA","A4Q9F1",1467,0,"Protein monoglycylase TTLL8",".",".",".",".","pfam03133","TTL","Tubulin-tyrosine ligase family. Tubulins and microtubules are subjected to several post-translational modifications of which the reversible detyrosination/tyrosination of the carboxy-terminal end of most alpha-tubulins has been extensively analysed. This modification cycle involves a specific carboxypeptidase and the activity of the tubulin-tyrosine ligase (TTL). The true physiological function of TTL has so far not been established. Tubulin-tyrosine ligase (TTL) catalyses the ATP-dependent post-translational addition of a tyrosine to the carboxy terminal end of detyrosinated alpha-tubulin. In normally cycling cells, the tyrosinated form of tubulin predominates. However, in breast cancer cells, the detyrosinated form frequently predominates, with a correlation to tumor aggressiveness. On the other hand, 3-nitrotyrosine has been shown to be incorporated, by TTL, into the carboxy terminal end of detyrosinated alpha-tubulin. This reaction is not reversible by the carboxypeptidase enzyme. Cells cultured in 3-nitrotyrosine rich medium showed evidence of altered microtubule structure and function, including altered cell morphology, epithelial barrier dysfunction, and apoptosis. Bacterial homologs of TTL are predicted to form peptide tags. Some of these are fused to a 2-oxoglutarate Fe(II)-dependent dioxygenase domain.",".",".",".",".","."]
["ENSRNOG00000066099",211,13.57372246,48,3.098969263,4.380076504,2.130956069,{"v":1.09324e-25,"d":"1.09E-25"},{"v":2.12376e-25,"d":"2.12E-25"},"up","yes","ENSRNOG00000066099","lncRNA","chr1:53816738-53818753:-","gi|149028494|gb|EDL83879.1|",251,{"v":1e-23,"d":"1.00E-23"},"rCG22859 [Rattus norvegicus]","gi|31455626|gb|AC111648.6|",513,0,"Rattus norvegicus 2 BAC CH230-103N18 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam02093","Gag_p30","Gag P30 core shell protein. According to Swiss-Prot annotation this protein is the viral core shell protein. P30 is essential for viral assembly.",".",".",".",".","."]
["ENSRNOG00000071212",138,8.87760047,16,1.032989754,8.594083756,3.103343837,{"v":1.87552E-25,"d":"1.88E-25"},{"v":3.62003e-25,"d":"3.62E-25"},"up","yes","ENSRNOG00000071212","lncRNA","chr19:47467970-47480763:-","gi|148701441|gb|EDL33388.1|",220,{"v":2E-19,"d":"2.00E-19"},"mCG1045525, partial [Mus musculus]","gi|354785512|gb|JN950013.1|",138,{"v":5e-64,"d":"5.00E-64"},"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Nkiras2:tm1e(EUCOMM)Wtsi; transgenic","P46935",52.4,4e-06,"E3 ubiquitin-protein ligase NEDD4",".",".",".",".","pfam09898","DUF2125","Uncharacterized protein conserved in bacteria (DUF2125). This domain, found in various hypothetical prokaryotic proteins, has no known function.",".",".",".",".","."]
["ENSRNOG00000026937",639,41.10715,318,20.53067137,2.002231162,1.001608546,{"v":1.94496e-25,"d":"1.94E-25"},{"v":3.75027e-25,"d":"3.75E-25"},"up","yes","Arsk","protein_coding","chr2:5574322-5631467:-","gi|114145523|ref|NP_001041382.1|",2901,0,"arylsulfatase K precursor [Rattus norvegicus]","gi|114145522|ref|NM_001047917.1|",1692,0,"Rattus norvegicus arylsulfatase family, member K (Arsk), mRNA","Q32KJ2",1122,0,"Arylsulfatase K","PA0031",139,{"v":2e-33,"d":"2.00E-33"},"COG3119","pfam00884","Sulfatase","Sulfatase.",".","GO:0005576|extracellular region;GO:0005764|lysosome;","GO:0004065|arylsulfatase activity;GO:0015024|glucuronate-2-sulfatase activity;GO:0046872|metal ion binding;","K12376","ARSK; arylsulfatase K [EC:3.1.6.-]"]
["ENSRNOG00000004555",157,10.0998788,24,1.549484632,6.518218115,2.704477629,{"v":2.88987e-25,"d":"2.89E-25"},{"v":5.54789e-25,"d":"5.55E-25"},"up","yes","Sec14l4","protein_coding","chr14:78912750-78956099:+","gi|29427387|sp|Q9Z1J8.1|S14L3_RAT",1935,0,"RecName: Full=SEC14-like protein 3; AltName: Full=45 kDa secretory protein; Short=rsec45","gi|4164417|emb|AJ132352.1|",1119,0,"Rattus norvegicus mRNA for 45 kDa secretory protein, partial","Q9Z1J8",749,0,"SEC14-like protein 3",".",".",".",".","pfam00650","CRAL_TRIO","CRAL/TRIO domain.",".",".","GO:0008289|lipid binding;",".","."]
["ENSRNOG00000037449",462,29.72066244,198,12.78324821,2.324969519,1.217211802,{"v":3.20614E-25,"d":"3.21E-25"},{"v":6.14471e-25,"d":"6.14E-25"},"up","yes","Pole","protein_coding","chr12:46345420-46393939:-","gi|312922377|ref|NP_001100622.2|",12000,0,"DNA polymerase epsilon catalytic subunit A [Rattus norvegicus]","gi|312922376|ref|NM_001107152.2|",7101,0,"Rattus norvegicus polymerase (DNA directed), epsilon, catalytic subunit (Pole), mRNA","Q9WVF7",4556,0,"DNA polymerase epsilon catalytic subunit A","SPBC25H2.13c",1760,0,"COG0417","pfam08490","DUF1744","Domain of unknown function (DUF1744). This domain is found on the epsilon catalytic subunit of DNA polymerase. It is found C terminal to pfam03104 and pfam00136.","GO:0000082|G1/S transition of mitotic cell cycle;GO:0000278|mitotic cell cycle;GO:0000731|DNA synthesis involved in DNA repair;GO:0006260|DNA replication;GO:0006272|leading strand elongation;GO:0006287|base-excision repair, gap-filling;GO:0006297|nucleotide-excision repair, DNA gap filling;GO:0045004|DNA replication proofreading;GO:0048568|embryonic organ development;GO:0071897|DNA biosynthetic process;GO:0090305|nucleic acid phosphodiester bond hydrolysis;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0008622|epsilon DNA polymerase complex;","GO:0000166|nucleotide binding;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003887|DNA-directed DNA polymerase activity;GO:0008270|zinc ion binding;GO:0008310|single-stranded DNA 3'-5' exodeoxyribonuclease activity;GO:0051539|4 iron, 4 sulfur cluster binding;","K02324","POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]"]
["ENSRNOG00000010868",112,7.205009077,7,0.451933018,15.94264813,3.994819381,{"v":3.74375e-25,"d":"3.74E-25"},{"v":7.15586e-25,"d":"7.16E-25"},"up","yes","Rims4","protein_coding","chr3:152524095-152584780:-","gi|33942097|ref|NP_898844.1|",1426,0,"regulating synaptic membrane exocytosis protein 4 [Mus musculus]","gi|672047994|ref|XM_008762471.1|",1845,0,"PREDICTED: Rattus norvegicus regulating synaptic membrane exocytosis 4 (Rims4), transcript variant X1, mRNA","P60191",553,0,"Regulating synaptic membrane exocytosis protein 4",".",".",".",".","pfam00168","C2","C2 domain.","GO:0006836|neurotransmitter transport;GO:0006887|exocytosis;GO:0007269|neurotransmitter secretion;GO:0042391|regulation of membrane potential;GO:0050807|regulation of synapse organization;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0045202|synapse;GO:0097060|synaptic membrane;GO:0098793|presynapse;GO:0098978|glutamatergic synapse;","GO:0031267|small GTPase binding;GO:0044325|ion channel binding;","K15299","RIMS4, RIM4; regulating synaptic membrane exocytosis protein 4"]
["ENSRNOG00000027040",420,27.01878404,171,11.040078,2.447336335,1.291212383,{"v":3.75663e-25,"d":"3.76E-25"},{"v":7.17808e-25,"d":"7.18E-25"},"up","yes","ENSRNOG00000027040","protein_coding","chr15:99968282-99993455:-","gi|849568472|ref|NP_001020805.2|",812,{"v":1e-98,"d":"1.00E-98"},"gamma-glutamylaminecyclotransferase [Rattus norvegicus]","gi|672079162|ref|XM_006252522.2|",1179,0,"PREDICTED: Rattus norvegicus gamma-glutamylamine cyclotransferase (Ggact), transcript variant X11, mRNA","Q4KM86",301,{"v":2e-94,"d":"2.00E-94"},"Gamma-glutamylaminecyclotransferase","MJ1514",57.8,1E-8,"COG2105","pfam06094","AIG2","AIG2-like family. AIG2 is an Arabidopsis proteins that exhibit RPS2- and avrRpt2-dependent induction early after infection with Pseudomonas syringae pv maculicola strain ES4326 carrying avrRpt2.","GO:0042219|cellular modified amino acid catabolic process;","GO:0005829|cytosol;","GO:0061929|gamma-glutamylaminecyclotransferase activity;","K19761","GGACT; gamma-glutamylaminecyclotransferase [EC:2.3.2.-]"]
["ENSRNOG00000015084",192,12.35144413,40,2.582474386,4.782794438,2.257853786,{"v":3.78054E-25,"d":"3.78E-25"},{"v":7.22135e-25,"d":"7.22E-25"},"up","yes","Necab2","protein_coding","chr19:47501302-47527684:+","gi|16905129|ref|NP_473436.1|",1811,0,"N-terminal EF-hand calcium-binding protein 2 [Mus musculus]","gi|19173781|ref|NM_133415.1|",1502,0,"Rattus norvegicus N-terminal EF-hand calcium binding protein 2 (Necab2), mRNA","F1LQY6",721,0,"N-terminal EF-hand calcium-binding protein 2",".",".",".",".","pfam03992","ABM","Antibiotic biosynthesis monooxygenase. This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.","GO:0019722|calcium-mediated signaling;GO:0042984|regulation of amyloid precursor protein biosynthetic process;GO:0060168|positive regulation of adenosine receptor signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:1900451|positive regulation of glutamate receptor signaling pathway;GO:1904021|negative regulation of G protein-coupled receptor internalization;GO:1905477|positive regulation of protein localization to membrane;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0030424|axon;GO:0030425|dendrite;","GO:0005509|calcium ion binding;GO:0031687|A2A adenosine receptor binding;GO:0031802|type 5 metabotropic glutamate receptor binding;GO:0042802|identical protein binding;","K23854","NECAB; N-terminal EF-hand calcium-binding protein"]
["ENSRNOG00000016949",412,26.50414053,166,10.7172687,2.473031261,1.306280476,{"v":4.01952e-25,"d":"4.02E-25"},{"v":7.67256E-25,"d":"7.67E-25"},"up","yes","Slc25a33","pseudogene","chr5:160195042-160219961:-","gi|189011685|ref|NP_001121046.1|",1640,0,"solute carrier family 25 member 33 [Rattus norvegicus]","gi|189011684|ref|NM_001127574.1|",1351,0,"Rattus norvegicus solute carrier family 25 member 33 (Slc25a33), mRNA","Q3TZX3",612,0,"Solute carrier family 25 member 33",".",".",".",".","pfam00153","Mito_carr","Mitochondrial carrier protein.","GO:0000002|mitochondrial genome maintenance;GO:0002082|regulation of oxidative phosphorylation;GO:0006390|mitochondrial transcription;GO:0006864|pyrimidine nucleotide transport;GO:0007005|mitochondrion organization;GO:0008284|positive regulation of cell proliferation;GO:0030307|positive regulation of cell growth;GO:0031930|mitochondria-nucleus signaling pathway;GO:0032869|cellular response to insulin stimulus;GO:0034551|mitochondrial respiratory chain complex III assembly;GO:0051881|regulation of mitochondrial membrane potential;GO:1903426|regulation of reactive oxygen species biosynthetic process;GO:1990314|cellular response to insulin-like growth factor stimulus;GO:1990519|pyrimidine nucleotide import into mitochondrion;","GO:0016021|integral component of membrane;GO:0031966|mitochondrial membrane;","GO:0015218|pyrimidine nucleotide transmembrane transporter activity;","K15116","SLC25A33_36, RIM2; solute carrier family 25, member 33/36"]
["ENSRNOG00000009571",550,35.381741,258,16.65695979,2.124141587,1.086879934,{"v":4.67697E-25,"d":"4.68E-25"},{"v":8.90091e-25,"d":"8.90E-25"},"up","yes","Wipf3","protein_coding","chr4:83550468-83629386:+","gi|22219452|ref|NP_671744.1|",915,{"v":2E-107,"d":"2.00E-107"},"WAS/WASL-interacting protein family member 3 [Rattus norvegicus]","gi|22219451|ref|NM_147211.1|",3786,0,"Rattus norvegicus WAS/WASL interacting protein family, member 3 (Wipf3), mRNA","Q9Z0G8",335,{"v":1E-100,"d":"1.00E-100"},"WAS/WASL-interacting protein family member 3",".",".",".",".","pfam02205","WH2","WH2 motif. The WH2 motif (for Wiskott Aldrich syndrome homology region 2) has been shown in WASP and Scar1 (mammalian homologue) to be the region that interacts with actin.","GO:0007283|spermatogenesis;GO:0030048|actin filament-based movement;GO:0030154|cell differentiation;","GO:0005737|cytoplasm;GO:0005884|actin filament;","GO:0003779|actin binding;GO:0017124|SH3 domain binding;","K19475","WIPF; WAS/WASL-interacting protein"]
["ENSRNOG00000014427",114,7.333669953,8,0.516494877,14.19892099,3.827709395,{"v":6.36546e-25,"d":"6.37E-25"},{"v":1.20661E-24,"d":"1.21E-24"},"up","yes","Chrnb4","protein_coding","chr8:55418313-55437027:-","gi|16258821|ref|NP_434693.1|",2463,0,"neuronal acetylcholine receptor subunit beta-4 precursor [Rattus norvegicus]","gi|1150980|gb|U42976.1|RNU42976",1595,0,"Rattus norvegicus neuronal nicotinic acetylcholine receptor subunit beta4 mRNA, complete cds","P12392",947,0,"Neuronal acetylcholine receptor subunit beta-4",".",".",".",".","pfam02932","Neur_chan_memb","Neurotransmitter-gated ion-channel transmembrane region. This family includes the four transmembrane helices that form the ion channel.","GO:0001508|action potential;GO:0006939|smooth muscle contraction;GO:0006940|regulation of smooth muscle contraction;GO:0007165|signal transduction;GO:0007268|chemical synaptic transmission;GO:0007271|synaptic transmission, cholinergic;GO:0007626|locomotory behavior;GO:0034220|ion transmembrane transport;GO:0035094|response to nicotine;GO:0035095|behavioral response to nicotine;GO:0042391|regulation of membrane potential;GO:0050877|nervous system process;GO:0051971|positive regulation of transmission of nerve impulse;GO:0060079|excitatory postsynaptic potential;GO:0060084|synaptic transmission involved in micturition;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005892|acetylcholine-gated channel complex;GO:0016020|membrane;GO:0032991|protein-containing complex;GO:0043005|neuron projection;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0098981|cholinergic synapse;","GO:0005515|protein binding;GO:0015464|acetylcholine receptor activity;GO:0022848|acetylcholine-gated cation-selective channel activity;GO:0030594|neurotransmitter receptor activity;GO:0042166|acetylcholine binding;GO:0044877|protein-containing complex binding;GO:1901363|heterocyclic compound binding;GO:1904315|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K04815","CHRNB4; nicotinic acetylcholine receptor beta-4"]
["ENSRNOG00000002408",299,19.23480102,98,6.327062246,3.04008405,1.604111211,{"v":8.09828e-25,"d":"8.10E-25"},{"v":1.53355E-24,"d":"1.53E-24"},"up","yes","Rbm47","protein_coding","chr14:42154142-42189431:+","gi|54312090|ref|NP_001005882.1|",2660,0,"RNA-binding protein 47 [Rattus norvegicus]","gi|672076156|ref|XM_006250949.2|",2367,0,"PREDICTED: Rattus norvegicus RNA binding motif protein 47 (Rbm47), transcript variant X3, mRNA","Q66H68",1029,0,"RNA-binding protein 47",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0002244|hematopoietic progenitor cell differentiation;GO:0016554|cytidine to uridine editing;","GO:0005634|nucleus;","GO:0003723|RNA binding;GO:0003729|mRNA binding;","K25083","RBM47; RNA-binding protein 47"]
["ENSRNOG00000007147",281,18.07685313,88,5.68144365,3.181735883,1.669814082,{"v":1.0334E-24,"d":"1.03E-24"},{"v":1.95109e-24,"d":"1.95E-24"},"up","yes","Cyp46a1","protein_coding","chr6:127243315-127274760:+","gi|564357223|ref|XP_006240610.1|",2337,0,"PREDICTED: cholesterol 24-hydroxylase isoform X1 [Rattus norvegicus]","gi|157817886|ref|NM_001108723.1|",2458,0,"Rattus norvegicus cytochrome P450, family 46, subfamily a, polypeptide 1 (Cyp46a1), mRNA","Q9WVK8",891,0,"Cholesterol 24-hydroxylase","BH0579",144,{"v":5E-36,"d":"5.00E-36"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0006707|cholesterol catabolic process;GO:0006805|xenobiotic metabolic process;GO:0042448|progesterone metabolic process;GO:1900271|regulation of long-term synaptic potentiation;GO:1903044|protein localization to membrane raft;","GO:0005789|endoplasmic reticulum membrane;GO:0030425|dendrite;GO:0098793|presynapse;GO:0098794|postsynapse;","GO:0005506|iron ion binding;GO:0008395|steroid hydroxylase activity;GO:0020037|heme binding;GO:0033781|cholesterol 24-hydroxylase activity;","K07440","CYP46A1; cholesterol 24-hydroxylase [EC:1.14.14.25]"]
["ENSRNOG00000039865",116,7.462330829,9,0.581056737,12.84268877,3.682875374,{"v":1.06029e-24,"d":"1.06E-24"},{"v":2.0012e-24,"d":"2.00E-24"},"up","yes","Vnn3","protein_coding","chr1:21571364-21583626:-","gi|157820363|ref|NP_001102606.1|",2702,0,"vascular non-inflammatory molecule 3 precursor [Rattus norvegicus]","gi|157820362|ref|NM_001109136.1|",1753,0,"Rattus norvegicus vanin 3 (Vnn3), mRNA","Q9QZ25",978,0,"Vascular non-inflammatory molecule 3","PH0642",68.6,{"v":4e-12,"d":"4.00E-12"},"COG0388","pfam00795","CN_hydrolase","Carbon-nitrogen hydrolase. This family contains hydrolases that break carbon-nitrogen bonds. The family includes: Nitrilase EC:3.5.5.1, Aliphatic amidase EC:3.5.1.4, Biotidinase EC:3.5.1.12, Beta-ureidopropionase EC:3.5.1.6. Nitrilase-related proteins generally have a conserved E-K-C catalytic triad, and are multimeric alpha-beta-beta-alpha sandwich proteins.","GO:0015939|pantothenate metabolic process;","GO:0005615|extracellular space;","GO:0017159|pantetheine hydrolase activity;","K08069","VNN; pantetheine hydrolase [EC:3.5.1.92]"]
["ENSRNOG00000049349",420,27.01878404,174,11.23376358,2.405140881,1.266121402,{"v":1.91698E-24,"d":"1.92E-24"},{"v":3.59673E-24,"d":"3.60E-24"},"up","yes","Tafa5","protein_coding","chr7:118613889-118834353:+","gi|625284690|ref|XP_007634048.1|",845,{"v":2e-103,"d":"2.00E-103"},"PREDICTED: uncharacterized protein LOC103158622 isoform X2 [Cricetulus griseus]","gi|300795380|ref|NM_001191991.1|",1827,0,"Rattus norvegicus family with sequence similarity 19 (chemokine (C-C motif)-like), member A5 (Fam19a5), mRNA","Q91WE9",266,{"v":2e-84,"d":"2.00E-84"},"Protein FAM19A5",".",".",".",".","pfam12020","TAFA","TAFA family. This family of secreted proteins are brain specific and thought to be chemokines. These proteins are found in vertebrates. Proteins in this family are typically between 94 to 133 amino acids in length and contain a number of conserved cysteines.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0061044|negative regulation of vascular wound healing;GO:1904706|negative regulation of vascular smooth muscle cell proliferation;GO:1904753|negative regulation of vascular associated smooth muscle cell migration;","GO:0005615|extracellular space;GO:0005737|cytoplasm;","GO:0001664|G protein-coupled receptor binding;GO:0005125|cytokine activity;GO:0048018|receptor ligand activity;","K25545","TAFA5, FAM19A5; chemokine-like protein TAFA5"]
["ENSRNOG00000046484",234,15.05332254,63,4.067397158,3.700971887,1.887904177,{"v":2.06521e-24,"d":"2.07E-24"},{"v":3.87103e-24,"d":"3.87E-24"},"up","yes","ENSRNOG00000046484","protein_coding","chrX:132468213-132478431:+","gi|672032811|ref|XP_006227616.2|",1883,0,"PREDICTED: coiled-coil domain-containing protein 160 isoform X1 [Rattus norvegicus]","gi|672088746|ref|XM_006257581.2|",1611,0,"PREDICTED: Rattus norvegicus coiled-coil domain containing 160 (Ccdc160), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam05701","WEMBL","Weak chloroplast movement under blue light. WEMBL consists of several plant proteins required for the chloroplast avoidance response under high intensity blue light. This avoidance response consists in the relocation of chloroplasts on the anticlinal side of exposed cells. Acts in association with PMI2 to maintain the velocity of chloroplast photo-relocation movement via the regulation of cp-actin filaments. Thus several member-sequences are described as \"myosin heavy chain-like\".",".",".",".",".","."]
["ENSRNOG00000008595",382,24.57422739,150,9.684278948,2.53753816,1.343429518,{"v":2.25484E-24,"d":"2.25E-24"},{"v":4.21679e-24,"d":"4.22E-24"},"up","yes","Ttc12","protein_coding","chr8:49799920-49847087:-","gi|564363561|ref|XP_006243066.1|",3696,0,"PREDICTED: tetratricopeptide repeat protein 12 isoform X2 [Rattus norvegicus]","gi|672061771|ref|XM_006243004.2|",3024,0,"PREDICTED: Rattus norvegicus tetratricopeptide repeat domain 12 (Ttc12), transcript variant X1, mRNA","Q8BW49",1267,0,"Tetratricopeptide repeat protein 12","ECU09g1180",68.6,{"v":8e-12,"d":"8.00E-12"},"COG0457","pfam13414","TPR_11","TPR repeat.","GO:0007288|sperm axoneme assembly;GO:0070286|axonemal dynein complex assembly;","GO:0005737|cytoplasm;GO:0005813|centrosome;",".","K24652","TTC12; tetratricopeptide repeat protein 12"]
["ENSRNOG00000005362",575,36.99000196,280,18.0773207,2.046210418,1.03295451,{"v":3.61341E-24,"d":"3.61E-24"},{"v":6.70478e-24,"d":"6.70E-24"},"up","yes","Rab3ip","protein_coding","chr7:52532401-52561043:-","gi|120474981|ref|NP_059009.2|",2188,0,"rab-3A-interacting protein [Rattus norvegicus]","gi|672058737|ref|XM_006241357.2|",1332,0,"PREDICTED: Rattus norvegicus RAB3A interacting protein (Rab3ip), transcript variant X1, mRNA","Q62739",838,0,"Rab-3A-interacting protein",".",".",".",".","pfam06428","Sec2p","GDP/GTP exchange factor Sec2p. In Saccharomyces cerevisiae, Sec2p is a GDP/GTP exchange factor for Sec4p, which is required for vesicular transport at the post-Golgi stage of yeast secretion.","GO:0006612|protein targeting to membrane;GO:0006887|exocytosis;GO:0033365|protein localization to organelle;GO:0050790|regulation of catalytic activity;GO:0051490|negative regulation of filopodium assembly;GO:0060271|cilium assembly;","GO:0005634|nucleus;GO:0005794|Golgi apparatus;GO:0005813|centrosome;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0030027|lamellipodium;GO:0048471|perinuclear region of cytoplasm;GO:0070319|Golgi to plasma membrane transport vesicle;GO:1990635|proximal dendrite;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0005515|protein binding;GO:0042802|identical protein binding;GO:0051020|GTPase binding;","K16779","RAB3IP, RABIN8; Rab-3A-interacting protein"]
["ENSRNOG00000016405",363,23.35194906,139,8.974098492,2.602149852,1.379704046,{"v":3.85775e-24,"d":"3.86E-24"},{"v":7.1535e-24,"d":"7.15E-24"},"up","yes","Pcsk4","protein_coding","chr7:9381361-9389585:+","gi|149034559|gb|EDL89296.1|",3131,0,"proprotein convertase subtilisin/kexin type 4, isoform CRA_b [Rattus norvegicus]","gi|19424239|ref|NM_133559.1|",2429,0,"Rattus norvegicus proprotein convertase subtilisin/kexin type 4 (Pcsk4), mRNA","Q78EH2",1076,0,"Proprotein convertase subtilisin/kexin type 4","SPAC22E12.09c_1",284,{"v":1e-85,"d":"1.00E-85"},"COG1404","pfam00082","Peptidase_S8","Subtilase family. Subtilases are a family of serine proteases. They appear to have independently and convergently evolved an Asp/Ser/His catalytic triad, like that found in the trypsin serine proteases (see pfam00089). Structure is an alpha/beta fold containing a 7-stranded parallel beta sheet, order 2314567.","GO:0007339|binding of sperm to zona pellucida;GO:0007340|acrosome reaction;GO:0009566|fertilization;GO:0016485|protein processing;GO:0016486|peptide hormone processing;GO:0022414|reproductive process;GO:0048240|sperm capacitation;","GO:0001669|acrosomal vesicle;GO:0002080|acrosomal membrane;GO:0005802|trans-Golgi network;GO:0016020|membrane;GO:0030173|integral component of Golgi membrane;","GO:0004252|serine-type endopeptidase activity;","K08671","PCSK4; proprotein convertase subtilisin/kexin type 4 [EC:3.4.21.-]"]
["ENSRNOG00000038375",287,18.46283576,94,6.068814808,3.042247349,1.605137456,{"v":6.58757e-24,"d":"6.59E-24"},{"v":1.21249e-23,"d":"1.21E-23"},"up","yes","AABR07026311.1","protein_coding","chr16:66654287-66655279:+","gi|958714273|ref|XP_014701553.1|",610,{"v":9e-76,"d":"9.00E-76"},"PREDICTED: histone H2A.Z [Equus asinus]","gi|298903825|emb|FQ213837.1|",962,0,"Rattus norvegicus TL0AAA45YF14 mRNA sequence","Q6YNC8",239,{"v":3e-77,"d":"3.00E-77"},"Histone H2A.Z","SPBC11B10.10c",167,{"v":3E-49,"d":"3.00E-49"},"COG5262","pfam00125","Histone","Core histone H2A/H2B/H3/H4.",".",".",".",".","."]
["ENSRNOG00000019390",151,9.713896166,24,1.549484632,6.269114238,2.648261619,{"v":7.42722e-24,"d":"7.43E-24"},{"v":1.36484e-23,"d":"1.36E-23"},"up","yes","Klhl40","protein_coding","chr8:121441287-121446800:+","gi|564366312|ref|XP_006244168.1|",3198,0,"PREDICTED: kelch-like protein 40 isoform X1 [Rattus norvegicus]","gi|672063610|ref|XM_006244106.2|",2331,0,"PREDICTED: Rattus norvegicus kelch-like family member 40 (Klhl40), transcript variant X1, mRNA","Q9D783",1222,0,"Kelch-like protein 40",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.","GO:0031397|negative regulation of protein ubiquitination;GO:0031398|positive regulation of protein ubiquitination;GO:0032435|negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032436|positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0048741|skeletal muscle fiber development;GO:0098528|skeletal muscle fiber differentiation;","GO:0005737|cytoplasm;GO:0031463|Cul3-RING ubiquitin ligase complex;GO:0031672|A band;GO:0031674|I band;",".","K10473","KBTBD5_10; kelch repeat and BTB domain-containing protein 5/10"]
["ENSRNOG00000006653",308,19.81377496,107,6.908118983,2.868186696,1.520138935,{"v":1.02956E-23,"d":"1.03E-23"},{"v":1.88284e-23,"d":"1.88E-23"},"up","yes","Slc38a4","protein_coding","chr7:128144807-128202995:-","gi|18543357|ref|NP_570104.1|",2680,0,"sodium-coupled neutral amino acid transporter 4 [Rattus norvegicus]","gi|66910541|gb|BC097292.1|",1929,0,"Rattus norvegicus solute carrier family 38, member 4, mRNA (cDNA clone MGC:114273 IMAGE:7462761), complete cds","Q9EQ25",1036,0,"Sodium-coupled neutral amino acid transporter 4","YEL064c",65.9,{"v":2e-10,"d":"2.00E-10"},"COG0814","pfam01490","Aa_trans","Transmembrane amino acid transporter protein. This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.","GO:0003333|amino acid transmembrane transport;GO:0006814|sodium ion transport;","GO:0005887|integral component of plasma membrane;","GO:0015171|amino acid transmembrane transporter activity;GO:0015293|symporter activity;","K14991","SLC38A4, SNAT4; solute carrier family 38 (sodium-coupled neutral amino acid transporter), member 4"]
["ENSRNOG00000014481",179,11.51514844,37,2.388788807,4.820496647,2.269181792,{"v":1.08789E-23,"d":"1.09E-23"},{"v":1.98761E-23,"d":"1.99E-23"},"up","yes","Adtrp","protein_coding","chr17:22930740-22993826:+","gi|62079023|ref|NP_001014166.1|",1048,{"v":6e-140,"d":"6.00E-140"},"androgen-dependent TFPI-regulating protein [Rattus norvegicus]","gi|62079022|ref|NM_001014144.1|",1096,0,"Rattus norvegicus androgen-dependent TFPI-regulating protein (Adtrp), mRNA","Q5M828",408,{"v":2e-141,"d":"2.00E-141"},"Androgen-dependent TFPI-regulating protein",".",".",".",".","pfam04750","Far-17a_AIG1","FAR-17a/AIG1-like protein. This family includes the hamster androgen-induced FAR-17a protein, and its human homologue, the AIG1 protein. The function of these proteins is unknown. This family also includes homologous regions from a number of other metazoan proteins.","GO:0001934|positive regulation of protein phosphorylation;GO:0002042|cell migration involved in sprouting angiogenesis;GO:0002686|negative regulation of leukocyte migration;GO:0003332|negative regulation of extracellular matrix constituent secretion;GO:0010628|positive regulation of gene expression;GO:0030195|negative regulation of blood coagulation;GO:0042758|long-chain fatty acid catabolic process;GO:0043491|protein kinase B signaling;GO:0050709|negative regulation of protein secretion;GO:0071383|cellular response to steroid hormone stimulus;GO:0140052|cellular response to oxidised low-density lipoprotein particle stimulus;GO:1903038|negative regulation of leukocyte cell-cell adhesion;GO:2000402|negative regulation of lymphocyte migration;","GO:0005901|caveola;GO:0009986|cell surface;GO:0012505|endomembrane system;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0016787|hydrolase activity;",".","."]
["ENSRNOG00000067047",366,23.54494038,143,9.232345931,2.550266265,1.350647882,{"v":1.33755e-23,"d":"1.34E-23"},{"v":2.43596e-23,"d":"2.44E-23"},"up","yes","ENSRNOG00000067047","lncRNA","chrX:645177-647888:-","gi|149045626|gb|EDL98626.1|",357,{"v":1E-35,"d":"1.00E-35"},"putative retrovirus-related gag protein, partial [Rattus norvegicus]","gi|46240867|gb|AC107531.8|",1223,0,"Rattus norvegicus 1 BAC CH230-158N3 (Children's Hospital Oakland Research Institute) complete sequence","P31790",71.2,{"v":3e-12,"d":"3.00E-12"},"Intracisternal A-particle Gag-related polyprotein",".",".",".",".","pfam02337","Gag_p10","Retroviral GAG p10 protein. This family consists of various retroviral GAG (core) polyproteins and encompasses the p10 region producing the p10 protein upon proteolytic cleavage of GAG by retroviral protease. The p10 or matrix protein (MA) is associated with the virus envelope glycoproteins in most mammalian retroviruses and may be involved in virus particle assembly, transport and budding. Some of the GAG polyproteins have alternate cleavage sites leading to the production of alternative and longer cleavage products (e.g. p19) the alignment of this family only covers the approximately N-terminal (GAG) 100 amino acid region of homology to p10.",".",".",".",".","."]
["ENSRNOG00000004588",542,34.8670975,261,16.85064537,2.069184695,1.049062425,{"v":2.02347e-23,"d":"2.02E-23"},{"v":3.66878E-23,"d":"3.67E-23"},"up","yes","Zbed4","protein_coding","chr7:119843169-119883899:+","gi|198278471|ref|NP_001128272.1|",5978,0,"zinc finger BED domain-containing protein 4 [Rattus norvegicus]","gi|688953326|ref|NM_001134800.3|",5104,0,"Rattus norvegicus zinc finger, BED-type containing 4 (Zbed4), mRNA","Q80WQ9",2204,0,"Zinc finger BED domain-containing protein 4",".",".",".",".","pfam02892","zf-BED","BED zinc finger.","GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0003723|RNA binding;GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0046983|protein dimerization activity;","K24640","ZBED4; zinc finger BED domain-containing protein 4"]
["ENSRNOG00000005269",126,8.105635211,15,0.968427895,8.369890267,3.065208709,{"v":3.9305e-23,"d":"3.93E-23"},{"v":7.07032e-23,"d":"7.07E-23"},"up","yes","Srl","protein_coding","chr10:11034035-11078101:+","gi|392351018|ref|XP_003750819.1|",3740,0,"PREDICTED: sarcalumenin isoform X1 [Rattus norvegicus]","gi|672066674|ref|XM_003750771.3|",5040,0,"PREDICTED: Rattus norvegicus sarcalumenin (Srl), transcript variant X1, mRNA","Q7TQ48",1282,0,"Sarcalumenin",".",".",".",".","pfam00350","Dynamin_N","Dynamin family.","GO:0002115|store-operated calcium entry;GO:0006897|endocytosis;GO:0014873|response to muscle activity involved in regulation of muscle adaptation;GO:0016197|endosomal transport;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0005525|GTP binding;",".","."]
["ENSRNOG00000002951",101,6.497374257,6,0.387371158,16.77299438,4.068068363,{"v":4.47508e-23,"d":"4.48E-23"},{"v":8.03981e-23,"d":"8.04E-23"},"up","yes","Ccnb3","protein_coding","chrX:15478065-15542885:+","gi|109510506|ref|XP_228779.4|",6179,0,"PREDICTED: G2/mitotic-specific cyclin-B3 isoform X2 [Rattus norvegicus]","gi|672032089|ref|XM_001064448.3|",3969,0,"PREDICTED: Rattus norvegicus cyclin B3 (Ccnb3), transcript variant X3, mRNA","Q810T2",1714,0,"G2/mitotic-specific cyclin-B3","SPAPB2B4.03",122,{"v":4e-28,"d":"4.00E-28"},"COG5024","pfam00134","Cyclin_N","Cyclin, N-terminal domain. Cyclins regulate cyclin dependent kinases (CDKs). Human cyclin-O is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.","GO:0000079|regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0010389|regulation of G2/M transition of mitotic cell cycle;GO:0044772|mitotic cell cycle phase transition;","GO:0000307|cyclin-dependent protein kinase holoenzyme complex;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0016607|nuclear speck;","GO:0016538|cyclin-dependent protein serine/threonine kinase regulator activity;GO:0019901|protein kinase binding;","K21771","CCNB3; G2/mitotic-specific cyclin-B3"]
["ENSRNOG00000011253",361,23.22328818,142,9.167784071,2.533140834,1.340927288,{"v":4.62988e-23,"d":"4.63E-23"},{"v":8.31269e-23,"d":"8.31E-23"},"up","yes","Trmt9b","protein_coding","chr16:55743018-55792144:-","gi|157823389|ref|NP_001100784.1|",2414,0,"putative methyltransferase KIAA1456 homolog [Rattus norvegicus]","gi|157823388|ref|NM_001107314.1|",2491,0,"Rattus norvegicus similar to 6430573F11Rik protein (RGD1304810), mRNA","Q80WQ4",814,0,"Probable tRNA methyltransferase 9B","SPAC13D6.03c",147,{"v":9e-39,"d":"9.00E-39"},"COG0500","pfam08241","Methyltransf_11","Methyltransferase domain. Members of this family are SAM dependent methyltransferases.","GO:0002098|tRNA wobble uridine modification;GO:0030488|tRNA methylation;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0000049|tRNA binding;GO:0008175|tRNA methyltransferase activity;GO:0016300|tRNA (uracil) methyltransferase activity;",".","."]
["ENSRNOG00000057616",542,34.8670975,263,16.97976909,2.05344945,1.038049433,{"v":4.78529e-23,"d":"4.79E-23"},{"v":8.58632e-23,"d":"8.59E-23"},"up","yes","Ptch2","protein_coding","chr5:130572312-130592405:+","gi|672053793|ref|XP_008762272.1|",5381,0,"PREDICTED: protein patched homolog 2 isoform X1 [Rattus norvegicus]","gi|672053792|ref|XM_008764050.1|",4304,0,"PREDICTED: Rattus norvegicus patched 2 (Ptch2), transcript variant X1, mRNA","O35595",2005,0,"Protein patched homolog 2",".",".",".",".","pfam12349","Sterol-sensing","Sterol-sensing domain of SREBP cleavage-activation. Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.","GO:0001558|regulation of cell growth;GO:0001709|cell fate determination;GO:0007224|smoothened signaling pathway;GO:0008544|epidermis development;GO:0009957|epidermal cell fate specification;GO:0042633|hair cycle;GO:0043588|skin development;GO:0045606|positive regulation of epidermal cell differentiation;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0005119|smoothened binding;GO:0008158|hedgehog receptor activity;GO:0097108|hedgehog family protein binding;",".","."]
["ENSRNOG00000017981",287,18.46283576,97,6.262500387,2.948157225,1.559813465,{"v":5.32863e-23,"d":"5.33E-23"},{"v":9.54027E-23,"d":"9.54E-23"},"up","yes","Mcm10","protein_coding","chr17:73266095-73287364:+","gi|157819197|ref|NP_001100836.1|",4354,0,"protein MCM10 homolog [Rattus norvegicus]","gi|157819196|ref|NM_001107366.1|",3942,0,"Rattus norvegicus minichromosome maintenance 10 replication initiation factor (Mcm10), mRNA","Q0VBD2",1438,0,"Protein MCM10 homolog",".",".",".",".","pfam09332","Mcm10","Mcm10 replication factor. Mcm10 is a eukaryotic DNA replication factor that regulates the stability and chromatin association of DNA polymerase alpha.","GO:0006270|DNA replication initiation;GO:0006974|cellular response to DNA damage stimulus;GO:0008283|cell proliferation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0031298|replication fork protection complex;","GO:0003688|DNA replication origin binding;GO:0003697|single-stranded DNA binding;GO:0019899|enzyme binding;GO:0042802|identical protein binding;GO:0046872|metal ion binding;","K10736","MCM10; minichromosome maintenance protein 10"]
["ENSRNOG00000032178",518,33.32316698,247,15.94677933,2.089648717,1.063260437,{"v":6.44038e-23,"d":"6.44E-23"},{"v":1.15127e-22,"d":"1.15E-22"},"up","yes","Cenpa","protein_coding","chr6:25700142-25711675:-","gi|149050808|gb|EDM02981.1|",554,{"v":6e-62,"d":"6.00E-62"},"similar to centromere protein A (predicted), isoform CRA_a [Rattus norvegicus]","gi|672055491|ref|XM_006239798.2|",2343,0,"PREDICTED: Rattus norvegicus centromere protein A (Cenpa), transcript variant X1, mRNA","O35216",139,{"v":1E-35,"d":"1.00E-35"},"Histone H3-like centromeric protein A","ECU09g0450",69.7,{"v":3e-12,"d":"3.00E-12"},"COG2036","pfam00125","Histone","Core histone H2A/H2B/H3/H4.","GO:0000132|establishment of mitotic spindle orientation;GO:0000281|mitotic cytokinesis;GO:0051382|kinetochore assembly;GO:0071459|protein localization to chromosome, centromeric region;","GO:0000775|chromosome, centromeric region;GO:0000776|kinetochore;GO:0000779|condensed chromosome, centromeric region;GO:0000786|nucleosome;GO:0000939|condensed chromosome inner kinetochore;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005721|pericentric heterochromatin;","GO:0003677|DNA binding;GO:0046982|protein heterodimerization activity;","K11495","CENPA; histone H3-like centromeric protein A"]
["ENSRNOG00000016260",459,29.52767113,207,13.36430495,2.209443083,1.143682767,{"v":7.45036e-23,"d":"7.45E-23"},{"v":1.3289E-22,"d":"1.33E-22"},"up","yes","Polr3g","protein_coding","chr2:11945217-11986125:-","gi|157822871|ref|NP_001102938.1|",564,{"v":3e-62,"d":"3.00E-62"},"DNA-directed RNA polymerase III subunit RPC7 [Rattus norvegicus]","gi|157822870|ref|NM_001109468.1|",3567,0,"Rattus norvegicus polymerase (RNA) III (DNA directed) polypeptide G (Polr3g), mRNA","Q6NXY9",207,{"v":9e-59,"d":"9.00E-59"},"DNA-directed RNA polymerase III subunit RPC7",".",".",".",".","pfam11705","RNA_pol_3_Rpc31","DNA-directed RNA polymerase III subunit Rpc31. RNA polymerase III contains seventeen subunits in yeasts and in human cells. Twelve of these are akin to RNA polymerase I or II and the other five are RNA pol III-specific, and form the functionally distinct groups (i) Rpc31-Rpc34-Rpc82, and (ii) Rpc37-Rpc53. Rpc31, Rpc34 and Rpc82 form a cluster of enzyme-specific subunits that contribute to transcription initiation in S.cerevisiae and H.sapiens. There is evidence that these subunits are anchored at or near the N-terminal Zn-fold of Rpc1, itself prolonged by a highly conserved but RNA polymerase III-specific domain.","GO:0006383|transcription by RNA polymerase III;GO:0008150|biological_process;GO:0008283|cell proliferation;GO:0032728|positive regulation of interferon-beta production;GO:0045089|positive regulation of innate immune response;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005666|RNA polymerase III complex;GO:0005829|cytosol;GO:0016604|nuclear body;","GO:0003674|molecular_function;GO:0003682|chromatin binding;","K03024","RPC7, POLR3G; DNA-directed RNA polymerase III subunit RPC7"]
["ENSRNOG00000013238",384,24.70288826,158,10.20077383,2.42166807,1.276001133,{"v":9.65587e-23,"d":"9.66E-23"},{"v":1.71586e-22,"d":"1.72E-22"},"up","yes","Tmem14a","protein_coding","chr9:23640594-23652379:+","gi|148682440|gb|EDL14387.1|",457,{"v":1E-52,"d":"1.00E-52"},"transmembrane protein 14A, isoform CRA_a, partial [Mus musculus]","gi|672064613|ref|XM_008766934.1|",1082,0,"PREDICTED: Rattus norvegicus transmembrane protein 14A (Tmem14a), transcript variant X1, mRNA","P56983",164,{"v":5e-48,"d":"5.00E-48"},"Transmembrane protein 14A",".",".",".",".","pfam03647","Tmemb_14","Transmembrane proteins 14C. This family of short membrane proteins are as yet uncharacterized.","GO:0006839|mitochondrial transport;GO:0043066|negative regulation of apoptotic process;GO:1901029|negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0031966|mitochondrial membrane;",".",".","."]
["ENSRNOG00000017637",192,12.35144413,46,2.969845544,4.158951685,2.056219925,{"v":1.51388E-22,"d":"1.51E-22"},{"v":2.6752e-22,"d":"2.68E-22"},"up","yes","Fbp2","protein_coding","chr17:2236336-2253698:+","gi|537210347|gb|ERE80540.1|",1820,0,"fructose-1,6-bisphosphatase isozyme 2-like protein [Cricetulus griseus]","gi|16758953|ref|NM_053716.1|",1259,0,"Rattus norvegicus fructose-bisphosphatase 2 (Fbp2), mRNA","Q9Z1N1",694,0,"Fructose-1,6-bisphosphatase isozyme 2","VC2544",301,{"v":9e-98,"d":"9.00E-98"},"COG0158","pfam00316","FBPase","Fructose-1-6-bisphosphatase.","GO:0005986|sucrose biosynthetic process;GO:0006000|fructose metabolic process;GO:0006002|fructose 6-phosphate metabolic process;GO:0006094|gluconeogenesis;GO:0016311|dephosphorylation;GO:0030388|fructose 1,6-bisphosphate metabolic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0030018|Z disc;GO:0030054|cell junction;","GO:0042132|fructose 1,6-bisphosphate 1-phosphatase activity;GO:0042802|identical protein binding;GO:0046872|metal ion binding;","K03841","FBP, fbp; fructose-1,6-bisphosphatase I [EC:3.1.3.11]"]
["ENSRNOG00000007069",213,13.70238333,57,3.680026,3.723447425,1.896638987,{"v":1.7049E-22,"d":"1.70E-22"},{"v":3.00625e-22,"d":"3.01E-22"},"up","yes","Adhfe1","protein_coding","chr5:9705970-9732517:-","gi|70794742|ref|NP_001020594.1|",2309,0,"hydroxyacid-oxoacid transhydrogenase, mitochondrial [Rattus norvegicus]","gi|672051852|ref|XM_008763508.1|",1733,0,"PREDICTED: Rattus norvegicus alcohol dehydrogenase, iron containing, 1 (Adhfe1), transcript variant X2, mRNA","Q4QQW3",894,0,"Hydroxyacid-oxoacid transhydrogenase, mitochondrial","TVN1284",315,{"v":3e-99,"d":"3.00E-99"},"COG1454","pfam00465","Fe-ADH","Iron-containing alcohol dehydrogenase.","GO:0006539|glutamate catabolic process via 2-oxoglutarate;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005739|mitochondrion;","GO:0003674|molecular_function;GO:0004022|alcohol dehydrogenase (NAD) activity;GO:0046872|metal ion binding;GO:0047988|hydroxyacid-oxoacid transhydrogenase activity;","K11173","ADHFE1; hydroxyacid-oxoacid transhydrogenase [EC:1.1.99.24]"]
["ENSRNOG00000010100",417,26.82579272,181,11.6856966,2.295609209,1.198877067,{"v":2.04274E-22,"d":"2.04E-22"},{"v":3.58976e-22,"d":"3.59E-22"},"up","yes","Tyw5","protein_coding","chr9:58961106-58979188:-","gi|281427194|ref|NP_001163944.1|",1687,0,"tRNA wybutosine-synthesizing protein 5 [Rattus norvegicus]","gi|281427193|ref|NM_001170473.1|",1472,0,"Rattus norvegicus tRNA-yW synthesizing protein 5 (Tyw5), transcript variant 1, mRNA","A2RSX7",636,0,"tRNA wybutosine-synthesizing protein 5",".",".",".",".","pfam13621","Cupin_8","Cupin-like domain. This cupin like domain shares similarity to the JmjC domain.","GO:0031591|wybutosine biosynthetic process;",".","GO:0000049|tRNA binding;GO:0005506|iron ion binding;GO:0016706|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0042803|protein homodimerization activity;GO:0102524|tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity;","K18066","TYW5; tRNA wybutosine-synthesizing protein 5 [EC:1.14.11.42]"]
["ENSRNOG00000013834",133,8.555948279,19,1.226675333,6.974908556,2.802174303,{"v":2.08141e-22,"d":"2.08E-22"},{"v":3.65546e-22,"d":"3.66E-22"},"up","yes","Svs5","protein_coding","chr3:152996146-152997756:+","gi|19424158|ref|NP_598200.1|",422,{"v":3E-49,"d":"3.00E-49"},"seminal vesicle secretory protein 5 precursor [Rattus norvegicus]","gi|672089715|ref|XM_008773873.1|",628,0,"PREDICTED: Rattus norvegicus seminal vesicle secretory protein 5 (LOC103694892), mRNA","P04812",165,{"v":4E-50,"d":"4.00E-50"},"Seminal vesicle secretory protein 5",".",".",".",".","pfam03038","Herpes_UL95","UL95 family. Members of this family, found in several herpesviruses, include EBV BGLF3 and other UL95 proteins (e.g. HCMV UL95, HVS-1 34, HSV6 U67). Their function is unknown.",".","GO:0005615|extracellular space;",".",".","."]
["ENSRNOG00000012324",147,9.456574413,25,1.614046491,5.858923187,2.550635536,{"v":2.16739E-22,"d":"2.17E-22"},{"v":3.80412e-22,"d":"3.80E-22"},"up","yes","Soga3","protein_coding","chr1:28620293-28701796:-","gi|149032835|gb|EDL87690.1|",3541,0,"similar to intracellular protein transport like (XM453) (predicted) [Rattus norvegicus]","gi|120953218|ref|NM_026138.2|",2587,0,"Mus musculus SOGA family member 3 (Soga3), mRNA","Q6NZL0",1323,0,"Protein SOGA3",".",".",".",".","pfam14818","DUF4482","Domain of unknown function (DUF4482). This family is found in eukaryotes, and is approximately 140 amino acids in length. The family is found in association with pfam11365.","GO:0010506|regulation of autophagy;","GO:0005615|extracellular space;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000051816",457,29.39901025,208,13.42886681,2.189239842,1.130430018,{"v":2.27538E-22,"d":"2.28E-22"},{"v":3.99017e-22,"d":"3.99E-22"},"up","yes","Tigar","protein_coding","chr4:159927139-159946029:-","gi|564349300|ref|XP_006237563.1|",1424,0,"PREDICTED: fructose-2,6-bisphosphatase TIGAR isoform X1 [Rattus norvegicus]","gi|672051083|ref|XM_006237501.2|",2707,0,"PREDICTED: Rattus norvegicus hypothetical protein LOC502894 (LOC502894), transcript variant X1, mRNA","Q8BZA9",501,{"v":1E-169,"d":"1.00E-169"},"Fructose-2,6-bisphosphatase TIGAR","Cgl2299",75.9,{"v":3e-14,"d":"3.00E-14"},"COG0406","pfam00300","His_Phos_1","Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centres on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.","GO:0002931|response to ischemia;GO:0006003|fructose 2,6-bisphosphate metabolic process;GO:0006974|cellular response to DNA damage stimulus;GO:0009410|response to xenobiotic stimulus;GO:0010332|response to gamma radiation;GO:0010666|positive regulation of cardiac muscle cell apoptotic process;GO:0016311|dephosphorylation;GO:0030388|fructose 1,6-bisphosphate metabolic process;GO:0043069|negative regulation of programmed cell death;GO:0043456|regulation of pentose-phosphate shunt;GO:0045739|positive regulation of DNA repair;GO:0045820|negative regulation of glycolytic process;GO:0060576|intestinal epithelial cell development;GO:0071279|cellular response to cobalt ion;GO:0071456|cellular response to hypoxia;GO:1901215|negative regulation of neuron death;GO:1901525|negative regulation of mitophagy;GO:1902153|regulation of response to DNA damage checkpoint signaling;GO:1903301|positive regulation of hexokinase activity;GO:1904024|negative regulation of glucose catabolic process to lactate via pyruvate;GO:2000378|negative regulation of reactive oxygen species metabolic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0005829|cytosol;","GO:0004083|bisphosphoglycerate 2-phosphatase activity;GO:0004331|fructose-2,6-bisphosphate 2-phosphatase activity;","K14634","TIGAR; fructose-2,6-bisphosphatase [EC:3.1.3.46]"]
["ENSRNOG00000065772",280,18.01252269,95,6.133376667,2.936803602,1.554246789,{"v":2.27548e-22,"d":"2.28E-22"},{"v":3.99017e-22,"d":"3.99E-22"},"up","yes","ENSRNOG00000065772","protein_coding","chr17:74728811-74736094:+","gi|672030279|ref|XP_008772248.1|",1703,0,"PREDICTED: uncharacterized protein LOC102547897 [Rattus norvegicus]","gi|672030278|ref|XM_008774026.1|",2427,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102547897 (LOC102547897), mRNA","Q6AYB4",147,{"v":1E-35,"d":"1.00E-35"},"Heat shock 70 kDa protein 14","SPAC22A12.15c",80.1,{"v":2E-14,"d":"2.00E-14"},"COG0443","pfam00012","HSP70","Hsp70 protein. Hsp70 chaperones help to fold many proteins. Hsp70 assisted folding involves repeated cycles of substrate binding and release. Hsp70 activity is ATP dependent. Hsp70 proteins are made up of two regions: the amino terminus is the ATPase domain and the carboxyl terminus is the substrate binding region.",".",".",".",".","."]
["ENSRNOG00000025757",326,20.97172285,123,7.941108738,2.640906143,1.40103303,{"v":2.54603E-22,"d":"2.55E-22"},{"v":4.45365e-22,"d":"4.45E-22"},"up","yes","Myh6","protein_coding","chr15:28417616-28441720:-","gi|186659510|ref|NP_058935.2|",9186,0,"myosin-6 [Rattus norvegicus]","gi|186659509|ref|NM_017239.2|",5914,0,"Rattus norvegicus myosin, heavy chain 6, cardiac muscle, alpha (Myh6), mRNA","P02563",3523,0,"Myosin-6","SPCC645.05c",775,0,"COG5022","pfam01576","Myosin_tail_1","Myosin tail. The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.","GO:0001701|in utero embryonic development;GO:0002026|regulation of the force of heart contraction;GO:0002027|regulation of heart rate;GO:0006936|muscle contraction;GO:0006941|striated muscle contraction;GO:0007512|adult heart development;GO:0007522|visceral muscle development;GO:0007568|aging;GO:0008016|regulation of heart contraction;GO:0008217|regulation of blood pressure;GO:0009408|response to heat;GO:0014898|cardiac muscle hypertrophy in response to stress;GO:0030048|actin filament-based movement;GO:0030049|muscle filament sliding;GO:0030239|myofibril assembly;GO:0043462|regulation of ATPase activity;GO:0045214|sarcomere organization;GO:0046034|ATP metabolic process;GO:0055009|atrial cardiac muscle tissue morphogenesis;GO:0055010|ventricular cardiac muscle tissue morphogenesis;GO:0055013|cardiac muscle cell development;GO:0060048|cardiac muscle contraction;GO:0060420|regulation of heart growth;GO:1905243|cellular response to 3,3',5-triiodo-L-thyronine;","GO:0001725|stress fiber;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005859|muscle myosin complex;GO:0016459|myosin complex;GO:0030016|myofibril;GO:0030018|Z disc;GO:0032982|myosin filament;","GO:0000146|microfilament motor activity;GO:0005516|calmodulin binding;GO:0005524|ATP binding;GO:0019901|protein kinase binding;GO:0030899|calcium-dependent ATPase activity;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;GO:0051015|actin filament binding;","K17751","MYH6_7; myosin heavy chain 6/7"]
["ENSRNOG00000000512",319,20.52140978,119,7.682861299,2.671063421,1.417414231,{"v":3.09995E-22,"d":"3.10E-22"},{"v":5.40604e-22,"d":"5.41E-22"},"up","yes","Slc26a8","protein_coding","chr20:6697723-6749478:-","gi|392338379|ref|XP_003753515.1|",4681,0,"PREDICTED: testis anion transporter 1 isoform X1 [Rattus norvegicus]","gi|672031539|ref|XM_003753467.3|",3351,0,"PREDICTED: Rattus norvegicus solute carrier family 26 (anion exchanger), member 8 (Slc26a8), transcript variant X1, mRNA","Q8R0C3",1541,0,"Testis anion transporter 1","SPBC3H7.02",105,{"v":4e-22,"d":"4.00E-22"},"COG0659","pfam00916","Sulfate_transp","Sulfate transporter family. Mutations in human SLC26A2 lead to several human diseases.","GO:0006820|anion transport;GO:0006821|chloride transport;GO:0008272|sulfate transport;GO:0015701|bicarbonate transport;GO:0019532|oxalate transport;GO:0030317|flagellated sperm motility;GO:0048240|sperm capacitation;GO:0051321|meiotic cell cycle;GO:1902358|sulfate transmembrane transport;GO:1902476|chloride transmembrane transport;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;","GO:0005254|chloride channel activity;GO:0008271|secondary active sulfate transmembrane transporter activity;GO:0015106|bicarbonate transmembrane transporter activity;GO:0015108|chloride transmembrane transporter activity;GO:0015116|sulfate transmembrane transporter activity;GO:0015301|anion:anion antiporter activity;GO:0019531|oxalate transmembrane transporter activity;","K14705","SLC26A8, TAT1; solute carrier family 26 (testis anion transporter), member 8"]
["ENSRNOG00000008596",232,14.92466166,68,4.390206457,3.399535263,1.765337535,{"v":3.10347e-22,"d":"3.10E-22"},{"v":5.41053e-22,"d":"5.41E-22"},"up","yes","Ttll9","protein_coding","chr3:141429444-141475865:+","gi|62078835|ref|NP_001014073.1|",2506,0,"probable tubulin polyglutamylase TTLL9 [Rattus norvegicus]","gi|62078834|ref|NM_001014051.1|",1746,0,"Rattus norvegicus tubulin tyrosine ligase like 9 (Ttll9), mRNA","Q641W7",969,0,"Probable tubulin polyglutamylase TTLL9",".",".",".",".","pfam03133","TTL","Tubulin-tyrosine ligase family. Tubulins and microtubules are subjected to several post-translational modifications of which the reversible detyrosination/tyrosination of the carboxy-terminal end of most alpha-tubulins has been extensively analysed. This modification cycle involves a specific carboxypeptidase and the activity of the tubulin-tyrosine ligase (TTL). The true physiological function of TTL has so far not been established. Tubulin-tyrosine ligase (TTL) catalyses the ATP-dependent post-translational addition of a tyrosine to the carboxy terminal end of detyrosinated alpha-tubulin. In normally cycling cells, the tyrosinated form of tubulin predominates. However, in breast cancer cells, the detyrosinated form frequently predominates, with a correlation to tumor aggressiveness. On the other hand, 3-nitrotyrosine has been shown to be incorporated, by TTL, into the carboxy terminal end of detyrosinated alpha-tubulin. This reaction is not reversible by the carboxypeptidase enzyme. Cells cultured in 3-nitrotyrosine rich medium showed evidence of altered microtubule structure and function, including altered cell morphology, epithelial barrier dysfunction, and apoptosis. Bacterial homologs of TTL are predicted to form peptide tags. Some of these are fused to a 2-oxoglutarate Fe(II)-dependent dioxygenase domain.","GO:0000226|microtubule cytoskeleton organization;GO:0006464|cellular protein modification process;GO:0018095|protein polyglutamylation;GO:0030317|flagellated sperm motility;","GO:0005737|cytoplasm;GO:0005874|microtubule;GO:0005929|cilium;GO:0036064|ciliary basal body;","GO:0005524|ATP binding;GO:0015631|tubulin binding;GO:0070740|tubulin-glutamic acid ligase activity;","K16603","TTLL9; tubulin polyglutamylase TTLL9 [EC:6.3.2.61]"]
["ENSRNOG00000028908",377,24.2525752,156,10.07165011,2.408004144,1.267837875,{"v":3.77332E-22,"d":"3.77E-22"},{"v":6.56031e-22,"d":"6.56E-22"},"up","yes","Eppin","protein_coding","chr3:153312396-153319310:-","gi|157822521|ref|NP_001102927.1|",594,{"v":1e-74,"d":"1.00E-74"},"eppin precursor [Rattus norvegicus]","gi|157822520|ref|NM_001109457.1|",731,0,"Rattus norvegicus epididymal peptidase inhibitor (Eppin), mRNA","D4A2Z2",233,{"v":5e-76,"d":"5.00E-76"},"Eppin",".",".",".",".","pfam00014","Kunitz_BPTI","Kunitz/Bovine pancreatic trypsin inhibitor domain. Indicative of a protease inhibitor, usually a serine protease inhibitor. Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure. Certain family members are similar to the tick anticoagulant peptide (TAP). This is a highly selective inhibitor of factor Xa in the blood coagulation pathways. TAP molecules are highly dipolar, and are arranged to form a twisted two- stranded antiparallel beta-sheet followed by an alpha helix.","GO:0010466|negative regulation of peptidase activity;GO:0010951|negative regulation of endopeptidase activity;GO:0042742|defense response to bacterium;GO:0090281|negative regulation of calcium ion import;GO:1901318|negative regulation of flagellated sperm motility;","GO:0001669|acrosomal vesicle;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0009986|cell surface;GO:0032991|protein-containing complex;","GO:0004867|serine-type endopeptidase inhibitor activity;","K23622","EPPIN; eppin"]
["ENSRNOG00000061085",486,31.26459296,229,14.78466586,2.11466348,1.080428096,{"v":3.95431E-22,"d":"3.95E-22"},{"v":6.8687e-22,"d":"6.87E-22"},"up","yes","Fancd2","protein_coding","chr4:146679179-146743412:+","gi|48843737|ref|NP_001001719.1|",7422,0,"Fanconi anemia group D2 protein homolog [Rattus norvegicus]","gi|48843736|ref|NM_001001719.1|",4365,0,"Rattus norvegicus Fanconi anemia, complementation group D2 (Fancd2), mRNA","Q6IV68",2831,0,"Fanconi anemia group D2 protein homolog",".",".",".",".","pfam14631","FancD2","Fanconi anaemia protein FancD2 nuclease. The Fanconi anaemia protein FancD2 is a nuclease necessary for the repair of DNA interstrand-crosslinks.","GO:0006281|DNA repair;GO:0006974|cellular response to DNA damage stimulus;GO:0007129|synapsis;GO:0007276|gamete generation;GO:0008150|biological_process;GO:0010332|response to gamma radiation;GO:0031573|intra-S DNA damage checkpoint;GO:0034599|cellular response to oxidative stress;GO:0036297|interstrand cross-link repair;GO:0045589|regulation of regulatory T cell differentiation;GO:0048854|brain morphogenesis;GO:0050727|regulation of inflammatory response;GO:0051090|regulation of DNA-binding transcription factor activity;GO:0097150|neuronal stem cell population maintenance;GO:1990918|double-strand break repair involved in meiotic recombination;GO:2000348|regulation of CD40 signaling pathway;","GO:0000793|condensed chromosome;GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005829|cytosol;GO:0016604|nuclear body;","GO:0003674|molecular_function;GO:0070182|DNA polymerase binding;","K10891","FANCD2; fanconi anemia group D2 protein"]
["ENSRNOG00000017545",478,30.74994945,224,14.46185656,2.126279522,1.088331267,{"v":4.9496e-22,"d":"4.95E-22"},{"v":8.56886e-22,"d":"8.57E-22"},"up","yes","Mrs2","protein_coding","chr17:40063962-40081887:+","gi|71051779|gb|AAH98916.1|",2232,0,"Mrs2 protein [Rattus norvegicus]","gi|672081844|ref|XM_006253937.2|",2303,0,"PREDICTED: Rattus norvegicus MRS2 magnesium transporter (Mrs2), transcript variant X1, mRNA","Q9ET09",754,0,"Magnesium transporter MRS2 homolog, mitochondrial",".",".",".",".","pfam01544","CorA","CorA-like Mg2+ transporter protein. The CorA transport system is the primary Mg2+ influx system of Salmonella typhimurium and Escherichia coli. CorA is virtually ubiquitous in the Bacteria and Archaea. There are also eukaryotic relatives of this protein. The family includes the MRS2 protein from yeast that is thought to be an RNA splicing protein. However its membership of this family suggests that its effect on splicing is due to altered magnesium levels in the cell.","GO:0006089|lactate metabolic process;GO:0015693|magnesium ion transport;GO:0045016|mitochondrial magnesium ion transmembrane transport;","GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0016021|integral component of membrane;","GO:0015095|magnesium ion transmembrane transporter activity;","K16075","MRS2, MFM1; magnesium transporter"]
["ENSRNOG00000026607",125,8.041304773,17,1.097551614,7.326584618,2.873140824,{"v":1.16506e-21,"d":"1.17E-21"},{"v":1.997E-21,"d":"2.00E-21"},"up","yes","Tnfsf18","protein_coding","chr13:73831252-73843169:+","gi|672027248|ref|XP_008760830.1|",867,{"v":1E-108,"d":"1.00E-108"},"PREDICTED: tumor necrosis factor ligand superfamily member 18 [Rattus norvegicus]","gi|672074632|ref|XM_008769705.1|",1924,0,"PREDICTED: Rattus norvegicus tumor necrosis factor (ligand) superfamily, member 18 (Tnfsf18), mRNA","Q7TS55",269,{"v":8e-84,"d":"8.00E-84"},"Tumor necrosis factor ligand superfamily member 18",".",".",".",".","pfam00229","TNF","TNF(tumor Necrosis Factor) family.","GO:0002309|T cell proliferation involved in immune response;GO:0002687|positive regulation of leukocyte migration;GO:0010759|positive regulation of macrophage chemotaxis;GO:0033209|tumor necrosis factor-mediated signaling pathway;GO:0042129|regulation of T cell proliferation;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0043254|regulation of protein complex assembly;GO:0045785|positive regulation of cell adhesion;GO:0050729|positive regulation of inflammatory response;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0090026|positive regulation of monocyte chemotaxis;GO:2000329|negative regulation of T-helper 17 cell lineage commitment;GO:2000508|regulation of dendritic cell chemotaxis;","GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0032813|tumor necrosis factor receptor superfamily binding;GO:0042802|identical protein binding;","K05479","TNFSF18, GITRL; tumor necrosis factor ligand superfamily member 18"]
["ENSRNOG00000052294",212,13.6380529,59,3.80914972,3.580340469,1.840096786,{"v":1.45839E-21,"d":"1.46E-21"},{"v":2.49082e-21,"d":"2.49E-21"},"up","yes","Spint3","protein_coding","chr3:153294010-153296779:-","gi|392339673|ref|XP_002726340.2|",473,{"v":9e-58,"d":"9.00E-58"},"PREDICTED: kunitz-type protease inhibitor 3 [Rattus norvegicus]","gi|672017715|ref|XM_002726294.4|",572,0,"PREDICTED: Rattus norvegicus serine peptidase inhibitor, Kunitz type, 3 (Spint3), mRNA","P49223",74.3,{"v":7e-16,"d":"7.00E-16"},"Kunitz-type protease inhibitor 3",".",".",".",".","pfam00014","Kunitz_BPTI","Kunitz/Bovine pancreatic trypsin inhibitor domain. Indicative of a protease inhibitor, usually a serine protease inhibitor. Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure. Certain family members are similar to the tick anticoagulant peptide (TAP). This is a highly selective inhibitor of factor Xa in the blood coagulation pathways. TAP molecules are highly dipolar, and are arranged to form a twisted two- stranded antiparallel beta-sheet followed by an alpha helix.","GO:0010951|negative regulation of endopeptidase activity;",".",".","K23422","SPINT3; Kunitz-type protease inhibitor 3"]
["ENSRNOG00000015003",467,30.04231463,219,14.13904726,2.124776449,1.087311061,{"v":1.56737e-21,"d":"1.57E-21"},{"v":2.67376e-21,"d":"2.67E-21"},"up","yes","Pex11a","protein_coding","chr1:133680091-133687172:-","gi|16758246|ref|NP_445939.1|",1123,{"v":1e-145,"d":"1.00E-145"},"peroxisomal membrane protein 11A [Rattus norvegicus]","gi|77628155|ref|NM_053487.2|",2256,0,"Rattus norvegicus peroxisomal biogenesis factor 11 alpha (Pex11a), mRNA","O70597",437,{"v":5e-147,"d":"5.00E-147"},"Peroxisomal membrane protein 11A",".",".",".",".","pfam05648","PEX11","Peroxisomal biogenesis factor 11 (PEX11). This family consists of several peroxisomal biogenesis factor 11 (PEX11) proteins from several eukaryotic species. The PEX11 peroxisomal membrane proteins promote peroxisome division in multiple eukaryotes.","GO:0007031|peroxisome organization;GO:0007165|signal transduction;GO:0016557|peroxisome membrane biogenesis;GO:0016559|peroxisome fission;GO:0044375|regulation of peroxisome size;GO:0050873|brown fat cell differentiation;","GO:0005777|peroxisome;GO:0005778|peroxisomal membrane;GO:0005779|integral component of peroxisomal membrane;GO:0032991|protein-containing complex;","GO:0042803|protein homodimerization activity;","K13351","PEX11A; peroxin-11A"]
["ENSRNOG00000005359",171,11.00050493,38,2.453350667,4.483869786,2.164744382,{"v":1.6336e-21,"d":"1.63E-21"},{"v":2.78424e-21,"d":"2.78E-21"},"up","yes","Csrnp3","protein_coding","chr3:50498633-50685950:+","gi|148695060|gb|EDL27007.1|",2587,0,"RIKEN cDNA A330102K23, partial [Mus musculus]","gi|403420593|ref|NM_001271225.1|",2535,0,"Rattus norvegicus cysteine-serine-rich nuclear protein 3 (Csrnp3), mRNA","P59055",986,0,"Cysteine/serine-rich nuclear protein 3",".",".",".",".","pfam01500","Keratin_B2","Keratin, high sulfur B2 protein. High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0043065|positive regulation of apoptotic process;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0043565|sequence-specific DNA binding;","K17494","CSRNP; cysteine/serine-rich nuclear protein"]
["ENSRNOG00000006926",152,9.778226604,29,1.87229393,5.222591628,2.384765899,{"v":1.66691e-21,"d":"1.67E-21"},{"v":2.83932e-21,"d":"2.84E-21"},"up","yes","Atp6v0d2","protein_coding","chr5:33336264-33385354:-","gi|58865520|ref|NP_001011972.1|",1882,0,"V-type proton ATPase subunit d 2 [Rattus norvegicus]","gi|58865519|ref|NM_001011972.1|",1299,0,"Rattus norvegicus ATPase H+ transporting V0 subunit D2 (Atp6v0d2), mRNA","Q5FVL0",729,0,"V-type proton ATPase subunit d 2","SPAC17A2.03c",357,{"v":4e-119,"d":"4.00E-119"},"COG1527","pfam01992","vATP-synt_AC39","ATP synthase (C/AC39) subunit. This family includes the AC39 subunit from vacuolar ATP synthase, and the C subunit from archaebacterial ATP synthase. The family also includes subunit C from the Sodium transporting ATP synthase from Enterococcus hirae.","GO:0007034|vacuolar transport;GO:0007035|vacuolar acidification;GO:0008150|biological_process;GO:1902600|proton transmembrane transport;","GO:0005768|endosome;GO:0005769|early endosome;GO:0016020|membrane;GO:0016324|apical plasma membrane;GO:0016471|vacuolar proton-transporting V-type ATPase complex;GO:0033179|proton-transporting V-type ATPase, V0 domain;GO:0033181|plasma membrane proton-transporting V-type ATPase complex;","GO:0003674|molecular_function;GO:0015078|proton transmembrane transporter activity;","K02146","ATPeV0D, ATP6D; V-type H+-transporting ATPase subunit d"]
["ENSRNOG00000023337",352,22.64431424,144,9.29690779,2.435682353,1.284325998,{"v":3.54405e-21,"d":"3.54E-21"},{"v":5.99205e-21,"d":"5.99E-21"},"up","yes","Sema3a","protein_coding","chr4:21287982-21494432:-","gi|8394255|ref|NP_059006.1|",4203,0,"semaphorin-3A precursor [Rattus norvegicus]","gi|672048845|ref|XM_006235990.2|",5183,0,"PREDICTED: Rattus norvegicus sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A (Sema3a), transcript variant X3, mRNA","Q63548",1623,0,"Semaphorin-3A",".",".",".",".","pfam01403","Sema","Sema domain. The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and human plexin A-3.","GO:0001755|neural crest cell migration;GO:0001764|neuron migration;GO:0002027|regulation of heart rate;GO:0006915|apoptotic process;GO:0007399|nervous system development;GO:0007411|axon guidance;GO:0007413|axonal fasciculation;GO:0008045|motor neuron axon guidance;GO:0010633|negative regulation of epithelial cell migration;GO:0010977|negative regulation of neuron projection development;GO:0021612|facial nerve structural organization;GO:0021637|trigeminal nerve structural organization;GO:0021675|nerve development;GO:0021772|olfactory bulb development;GO:0021785|branchiomotor neuron axon guidance;GO:0021828|gonadotrophin-releasing hormone neuronal migration to the hypothalamus;GO:0030335|positive regulation of cell migration;GO:0030517|negative regulation of axon extension;GO:0036486|ventral trunk neural crest cell migration;GO:0048813|dendrite morphogenesis;GO:0048841|regulation of axon extension involved in axon guidance;GO:0048843|negative regulation of axon extension involved in axon guidance;GO:0048846|axon extension involved in axon guidance;GO:0050919|negative chemotaxis;GO:0060385|axonogenesis involved in innervation;GO:0060666|dichotomous subdivision of terminal units involved in salivary gland branching;GO:0061549|sympathetic ganglion development;GO:0061551|trigeminal ganglion development;GO:0071526|semaphorin-plexin signaling pathway;GO:0097490|sympathetic neuron projection extension;GO:0097491|sympathetic neuron projection guidance;GO:0150020|basal dendrite arborization;GO:1901166|neural crest cell migration involved in autonomic nervous system development;GO:1902285|semaphorin-plexin signaling pathway involved in neuron projection guidance;GO:1902287|semaphorin-plexin signaling pathway involved in axon guidance;GO:1903045|neural crest cell migration involved in sympathetic nervous system development;GO:1903375|facioacoustic ganglion development;GO:2000020|positive regulation of male gonad development;GO:2001224|positive regulation of neuron migration;","GO:0005615|extracellular space;GO:0005887|integral component of plasma membrane;GO:0030424|axon;GO:0030425|dendrite;","GO:0030215|semaphorin receptor binding;GO:0038191|neuropilin binding;GO:0045499|chemorepellent activity;","K06840","SEMA3; semaphorin 3"]
["ENSRNOG00000046053",496,31.90789734,241,15.55940818,2.050714075,1.036126355,{"v":3.62778e-21,"d":"3.63E-21"},{"v":6.12999e-21,"d":"6.13E-21"},"up","yes","Nudt10","protein_coding","chrX:16326598-16333145:+","gi|674041728|ref|XP_008826691.1|",665,{"v":1E-78,"d":"1.00E-78"},"PREDICTED: diphosphoinositol polyphosphate phosphohydrolase 3-beta [Nannospalax galili]","gi|672032093|ref|XM_006227291.2|",1761,0,"PREDICTED: Rattus norvegicus nudix (nucleoside diphosphate linked moiety X)-type motif 11 (Nudt11), transcript variant X1, mRNA","P0C028",260,{"v":6e-80,"d":"6.00E-80"},"Diphosphoinositol polyphosphate phosphohydrolase 3-beta",".",".",".",".","pfam00293","NUDIX","NUDIX domain.","GO:0071543|diphosphoinositol polyphosphate metabolic process;GO:1901907|diadenosine pentaphosphate catabolic process;GO:1901909|diadenosine hexaphosphate catabolic process;GO:1901911|adenosine 5'-(hexahydrogen pentaphosphate) catabolic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0000298|endopolyphosphatase activity;GO:0008486|diphosphoinositol-polyphosphate diphosphatase activity;GO:0034431|bis(5'-adenosyl)-hexaphosphatase activity;GO:0034432|bis(5'-adenosyl)-pentaphosphatase activity;GO:0050072|m7G(5')pppN diphosphatase activity;","K07766","E3.6.1.52; diphosphoinositol-polyphosphate diphosphatase [EC:3.6.1.52]"]
["ENSRNOG00000022844",163,10.48586142,35,2.259665088,4.640449366,2.214264518,{"v":4.02219e-21,"d":"4.02E-21"},{"v":6.78439e-21,"d":"6.78E-21"},"up","yes","Pdzrn4","protein_coding","chr7:123816961-123965491:+","gi|257196174|ref|NP_001101577.2|",3738,0,"PDZ domain containing RING finger 4 [Rattus norvegicus]","gi|257196173|ref|NM_001108107.2|",3368,0,"Rattus norvegicus PDZ domain containing RING finger 4 (Pdzrn4), mRNA","Q6ZMN7",1203,0,"PDZ domain-containing RING finger protein 4",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.",".",".",".","K15682","PDZRN3_4, LNX3_4; ligand of Numb protein X 3/4 [EC:2.3.2.27]"]
["ENSRNOG00000037302",242,15.56796604,77,4.971263193,3.131591597,1.646896077,{"v":4.06391e-21,"d":"4.06E-21"},{"v":6.85275e-21,"d":"6.85E-21"},"up","yes","Rad51","protein_coding","chr3:106100381-106125035:+","gi|444706842|gb|ELW48160.1|",1768,0,"Protein CASC5 [Tupaia chinensis]","gi|672046590|ref|XM_006234784.2|",2132,0,"PREDICTED: Rattus norvegicus RAD51 recombinase (Rad51), transcript variant X1, mRNA","Q2KJ94",668,0,"DNA repair protein RAD51 homolog 1","SPAC644.14c",510,{"v":7E-175,"d":"7.00E-175"},"COG0468","pfam08423","Rad51","Rad51. Rad51 is a DNA repair and recombination protein and is a homologue of the bacterial ATPase RecA protein.","GO:0000722|telomere maintenance via recombination;GO:0000724|double-strand break repair via homologous recombination;GO:0000730|DNA recombinase assembly;GO:0001932|regulation of protein phosphorylation;GO:0006268|DNA unwinding involved in DNA replication;GO:0006312|mitotic recombination;GO:0006974|cellular response to DNA damage stimulus;GO:0007127|meiosis I;GO:0007131|reciprocal meiotic recombination;GO:0009410|response to xenobiotic stimulus;GO:0009636|response to toxic substance;GO:0010165|response to X-ray;GO:0010569|regulation of double-strand break repair via homologous recombination;GO:0010833|telomere maintenance via telomere lengthening;GO:0014070|response to organic cyclic compound;GO:0031297|replication fork processing;GO:0032200|telomere organization;GO:0036297|interstrand cross-link repair;GO:0042148|strand invasion;GO:0051106|positive regulation of DNA ligation;GO:0051321|meiotic cell cycle;GO:0070192|chromosome organization involved in meiotic cell cycle;GO:0071312|cellular response to alkaloid;GO:0071479|cellular response to ionizing radiation;GO:0071480|cellular response to gamma radiation;GO:0072711|cellular response to hydroxyurea;GO:0072719|cellular response to cisplatin;GO:0072757|cellular response to camptothecin;GO:1904631|response to glucoside;GO:1990414|replication-born double-strand break repair via sister chromatid exchange;GO:1990426|mitotic recombination-dependent replication fork processing;","GO:0000228|nuclear chromosome;GO:0000781|chromosome, telomeric region;GO:0000785|chromatin;GO:0000793|condensed chromosome;GO:0000794|condensed nuclear chromosome;GO:0000800|lateral element;GO:0005634|nucleus;GO:0005694|chromosome;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0016605|PML body;GO:0032991|protein-containing complex;GO:0035861|site of double-strand break;GO:0048471|perinuclear region of cytoplasm;","GO:0000150|recombinase activity;GO:0003674|molecular_function;GO:0003682|chromatin binding;GO:0003690|double-stranded DNA binding;GO:0003697|single-stranded DNA binding;GO:0005524|ATP binding;GO:0008022|protein C-terminus binding;GO:0008094|DNA-dependent ATPase activity;GO:0017116|single-stranded DNA-dependent ATP-dependent DNA helicase activity;GO:0019899|enzyme binding;GO:0042802|identical protein binding;GO:0070182|DNA polymerase binding;","K04482","RAD51; DNA repair protein RAD51"]
["ENSRNOG00000025522",183,11.77247019,45,2.905283684,4.052089732,2.018666123,{"v":4.29118e-21,"d":"4.29E-21"},{"v":7.22957e-21,"d":"7.23E-21"},"up","yes","Atf7ip2","protein_coding","chr10:5403105-5446142:-","gi|564370396|ref|XP_006245794.1|",2281,0,"PREDICTED: activating transcription factor 7-interacting protein 2 isoform X2 [Rattus norvegicus]","gi|672066595|ref|XM_006245732.2|",2020,0,"PREDICTED: Rattus norvegicus activating transcription factor 7 interacting protein 2 (Atf7ip2), transcript variant X2, mRNA","Q3UL97",773,0,"Activating transcription factor 7-interacting protein 2",".",".",".",".","pfam00041","fn3","Fibronectin type III domain.",".","GO:0005634|nucleus;",".",".","."]
["ENSRNOG00000019296",120,7.719652582,16,1.032989754,7.47311631,2.901709976,{"v":4.7598e-21,"d":"4.76E-21"},{"v":8.00255e-21,"d":"8.00E-21"},"up","yes","Gnat2","protein_coding","chr2:195726762-195735866:+","gi|148670000|gb|EDL01947.1|",1940,0,"mCG4057, isoform CRA_b, partial [Mus musculus]","gi|312836783|ref|NM_001108950.2|",1525,0,"Rattus norvegicus guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 (Gnat2), mRNA","P50149",723,0,"Guanine nucleotide-binding protein G(t) subunit alpha-2",".",".",".",".","pfam00503","G-alpha","G-protein alpha subunit. G proteins couple receptors of extracellular signals to intracellular signaling pathways. The G protein alpha subunit binds guanyl nucleotide and is a weak GTPase. A set of residues that are unique to G-alpha as compared to its ancestor the Arf-like family form a ring of residues centered on the nucleotide binding site. A Ggamma is found fused to an inactive Galpha in the Dictyostelium protein gbqA.","GO:0001580|detection of chemical stimulus involved in sensory perception of bitter taste;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007188|adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007601|visual perception;GO:0007602|phototransduction;GO:0009642|response to light intensity;GO:0046549|retinal cone cell development;GO:0050908|detection of light stimulus involved in visual perception;","GO:0001750|photoreceptor outer segment;GO:0001917|photoreceptor inner segment;GO:0005834|heterotrimeric G-protein complex;","GO:0001664|G protein-coupled receptor binding;GO:0003674|molecular_function;GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0031683|G-protein beta/gamma-subunit complex binding;","K04631","GNAT1_2; guanine nucleotide-binding protein G(t) subunit alpha 1/2"]
["ENSRNOG00000013970",310,19.94243584,118,7.618299439,2.617701758,1.388300737,{"v":4.94264e-21,"d":"4.94E-21"},{"v":8.30263e-21,"d":"8.30E-21"},"up","yes","Cdt1","protein_coding","chr19:50620713-50625659:+","gi|157818675|ref|NP_001099662.1|",2259,0,"DNA replication factor Cdt1 [Rattus norvegicus]","gi|157818674|ref|NM_001106192.1|",2239,0,"Rattus norvegicus chromatin licensing and DNA replication factor 1 (Cdt1), mRNA","Q8R4E9",795,0,"DNA replication factor Cdt1",".",".",".",".","pfam08839","CDT1","DNA replication factor CDT1 like. CDT1 is a component of the replication licensing system and promotes the loading of the mini-chromosome maintenance complex onto chromatin. Geminin is an inhibitor of CDT1 and prevents inappropriate re-initiation of replication on an already fired origin. This region of CDT1 binds to Geminin.","GO:0000076|DNA replication checkpoint;GO:0000278|mitotic cell cycle;GO:0007059|chromosome segregation;GO:0030174|regulation of DNA-dependent DNA replication initiation;GO:0031334|positive regulation of protein complex assembly;GO:0033044|regulation of chromosome organization;GO:0033262|regulation of nuclear cell cycle DNA replication;GO:0035563|positive regulation of chromatin binding;GO:0045740|positive regulation of DNA replication;GO:0051301|cell division;GO:0051315|attachment of mitotic spindle microtubules to kinetochore;GO:0051383|kinetochore organization;GO:0071163|DNA replication preinitiation complex assembly;GO:0072708|response to sorbitol;GO:1902426|deactivation of mitotic spindle assembly checkpoint;GO:1902595|regulation of DNA replication origin binding;GO:1905341|negative regulation of protein localization to kinetochore;GO:1905342|positive regulation of protein localization to kinetochore;GO:2000105|positive regulation of DNA-dependent DNA replication;","GO:0000776|kinetochore;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0016604|nuclear body;","GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0070182|DNA polymerase binding;","K10727","CDT1; chromatin licensing and DNA replication factor 1"]
["ENSRNOG00000018748",145,9.327913537,27,1.743170211,5.351120321,2.419840968,{"v":6.49186E-21,"d":"6.49E-21"},{"v":1.08667e-20,"d":"1.09E-20"},"up","yes","Slc16a11","protein_coding","chr10:54927725-54942915:+","gi|53850584|ref|NP_001005530.1|",1164,{"v":8e-139,"d":"8.00E-139"},"monocarboxylate transporter 13 [Rattus norvegicus]","gi|354794370|gb|JN958871.1|",1737,0,"Mus musculus targeted deletion, lacZ-tagged mutant allele Slc16a11:tm1(KOMP)Ucd; transgenic","Q66HE2",452,{"v":3e-140,"d":"3.00E-140"},"Monocarboxylate transporter 13","AF0367",63.5,5e-09,"COG0477","pfam07690","MFS_1","Major Facilitator Superfamily.","GO:0006629|lipid metabolic process;GO:0015718|monocarboxylic acid transport;GO:1901475|pyruvate transmembrane transport;","GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;","GO:0008028|monocarboxylic acid transmembrane transporter activity;GO:0050833|pyruvate transmembrane transporter activity;","K08188","SLC16A11; MFS transporter, MCT family, solute carrier family 16 (monocarboxylic acid transporters), member 11"]
["ENSRNOG00000027145",180,11.57947887,44,2.840721825,4.07624526,2.027240858,{"v":7.02105e-21,"d":"7.02E-21"},{"v":1.17421e-20,"d":"1.17E-20"},"up","yes","Rora","protein_coding","chr8:69301733-70025931:+","gi|7305439|ref|NP_038674.1|",2599,0,"nuclear receptor ROR-alpha isoform 1 [Mus musculus]","gi|672062535|ref|XM_008766410.1|",2031,0,"PREDICTED: Rattus norvegicus RAR-related orphan receptor A (Rora), transcript variant X4, mRNA","P51448",1004,0,"Nuclear receptor ROR-alpha",".",".",".",".","pfam00105","zf-C4","Zinc finger, C4 type (two domains). In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.","GO:0001525|angiogenesis;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006805|xenobiotic metabolic process;GO:0006809|nitric oxide biosynthetic process;GO:0007623|circadian rhythm;GO:0008589|regulation of smoothened signaling pathway;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0010906|regulation of glucose metabolic process;GO:0019218|regulation of steroid metabolic process;GO:0021702|cerebellar Purkinje cell differentiation;GO:0021930|cerebellar granule cell precursor proliferation;GO:0030522|intracellular receptor signaling pathway;GO:0032922|circadian regulation of gene expression;GO:0036315|cellular response to sterol;GO:0042632|cholesterol homeostasis;GO:0042692|muscle cell differentiation;GO:0042752|regulation of circadian rhythm;GO:0042753|positive regulation of circadian rhythm;GO:0043030|regulation of macrophage activation;GO:0043124|negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045599|negative regulation of fat cell differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046068|cGMP metabolic process;GO:0050728|negative regulation of inflammatory response;GO:0070328|triglyceride homeostasis;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071456|cellular response to hypoxia;GO:0072539|T-helper 17 cell differentiation;","GO:0005634|nucleus;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001222|transcription corepressor binding;GO:0001223|transcription coactivator binding;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0004879|nuclear receptor activity;GO:0005515|protein binding;GO:0008013|beta-catenin binding;GO:0008142|oxysterol binding;GO:0008270|zinc ion binding;GO:0043565|sequence-specific DNA binding;GO:0098531|transcription factor activity, direct ligand regulated sequence-specific DNA binding;","K08532","NR1F1, RORA; RAR-related orphan receptor alpha"]
["ENSRNOG00000012835",441,28.36972324,205,13.23518123,2.143508483,1.099974127,{"v":8.88331e-21,"d":"8.88E-21"},{"v":1.48219E-20,"d":"1.48E-20"},"up","yes","Espl1","protein_coding","chr7:133424130-133450984:+","gi|282158055|ref|NP_001164073.1|",10127,0,"separin [Rattus norvegicus]","gi|282158054|ref|NM_001170602.1|",5291,0,"Rattus norvegicus extra spindle pole bodies like 1, separase (Espl1), mRNA","P60330",3487,0,"Separin","SPCC5E4.04",144,{"v":2e-33,"d":"2.00E-33"},"COG5155","pfam03568","Peptidase_C50","Peptidase family C50.","GO:0000070|mitotic sister chromatid segregation;GO:0000212|meiotic spindle organization;GO:0000278|mitotic cell cycle;GO:0006508|proteolysis;GO:0007059|chromosome segregation;GO:0007127|meiosis I;GO:0045143|homologous chromosome segregation;GO:0051307|meiotic chromosome separation;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0072686|mitotic spindle;","GO:0004197|cysteine-type endopeptidase activity;GO:0008233|peptidase activity;GO:0008234|cysteine-type peptidase activity;","K02365","ESP1; separase [EC:3.4.22.49]"]
["ENSRNOG00000024411",461,29.656332,219,14.13904726,2.097477394,1.068655261,{"v":9.94693e-21,"d":"9.95E-21"},{"v":1.65482e-20,"d":"1.65E-20"},"up","yes","Cbr4","protein_coding","chr16:28617224-28645712:-","gi|32996723|ref|NP_872613.1|",1156,{"v":1E-155,"d":"1.00E-155"},"carbonyl reductase family member 4 [Rattus norvegicus]","gi|402745872|ref|NM_182672.2|",1167,0,"Rattus norvegicus carbonyl reductase 4 (Cbr4), mRNA","Q7TS56",449,{"v":3E-157,"d":"3.00E-157"},"Carbonyl reductase family member 4","aq_1716",171,{"v":2e-49,"d":"2.00E-49"},"COG1028","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.","GO:0006633|fatty acid biosynthetic process;GO:0044597|daunorubicin metabolic process;GO:0044598|doxorubicin metabolic process;GO:0051289|protein homotetramerization;GO:0051290|protein heterotetramerization;","GO:0005759|mitochondrial matrix;GO:1990204|oxidoreductase complex;","GO:0003955|NAD(P)H dehydrogenase (quinone) activity;GO:0004316|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity;GO:0008753|NADPH dehydrogenase (quinone) activity;GO:0016616|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0048038|quinone binding;GO:0070402|NADPH binding;","K11539","CBR4; carbonyl reductase 4 / 3-oxoacyl-[acyl-carrier protein] reductase beta subunit [EC:1.1.1.-]"]
["ENSRNOG00000017693",255,16.40426174,86,5.55231993,2.954487843,1.562908063,{"v":1.1424e-20,"d":"1.14E-20"},{"v":1.89558E-20,"d":"1.90E-20"},"up","yes","Slc2a5","protein_coding","chr5:160583234-160611106:+","gi|1170105|sp|P43427.1|GTR5_RAT",2387,0,"RecName: Full=Solute carrier family 2, facilitated glucose transporter member 5; AltName: Full=Fructose transporter; AltName: Full=Glucose transporter type 5, small intestine; Short=GLUT-5","gi|13929043|ref|NM_031741.1|",2142,0,"Rattus norvegicus solute carrier family 2 member 5 (Slc2a5), mRNA","P43427",924,0,"Solute carrier family 2, facilitated glucose transporter member 5",".",".",".",".","pfam00083","Sugar_tr","Sugar (and other) transporter.","GO:0003044|regulation of systemic arterial blood pressure mediated by a chemical signal;GO:0009750|response to fructose;GO:0015755|fructose transmembrane transport;GO:0071332|cellular response to fructose stimulus;GO:1904659|glucose transmembrane transport;GO:1990539|fructose import across plasma membrane;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0016324|apical plasma membrane;GO:0042383|sarcolemma;","GO:0005353|fructose transmembrane transporter activity;GO:0005355|glucose transmembrane transporter activity;GO:0070061|fructose binding;","K08143","SLC2A5, GLUT5; MFS transporter, SP family, solute carrier family 2 (facilitated glucose/fructose transporter), member 5"]
["ENSRNOG00000006996",301,19.36346189,114,7.360052001,2.630886561,1.395549043,{"v":1.28436E-20,"d":"1.28E-20"},{"v":2.12743E-20,"d":"2.13E-20"},"up","yes","Mms22l","protein_coding","chr5:38197779-38313745:+","gi|209413780|ref|NP_001129252.1|",6358,0,"protein MMS22-like [Rattus norvegicus]","gi|209413779|ref|NM_001135780.1|",4379,0,"Rattus norvegicus MMS22-like, DNA repair protein (Mms22l), mRNA","B1AUR6",2222,0,"Protein MMS22-like",".",".",".",".","pfam14910","MMS22L_N","S-phase genomic integrity recombination mediator, N-terminal. MMS22L (Methyl methanesulfonate-sensitivity protein 22-like) is found in yeast, plants and vertebrates, and is integrally concerned with DNA forking and repair mechanisms during replication. MMS22L complexes with TONSL and this complex accumulates at regions of ssDNA associated with distressed replication forks or at processed DNA breaks. Its depletion results in high levels of endogenous DNA double-strand breaks caused by an inability to complete DNA synthesis after replication fork collapse. Thus the complex mediates recovery from replication stress and homologous recombination in vertebrates, yeasts and plants. This family is the more N-terminal region of the proteins.","GO:0000724|double-strand break repair via homologous recombination;GO:0031297|replication fork processing;","GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0043596|nuclear replication fork;",".",".","."]
["ENSRNOG00000016640",300,19.29913146,114,7.360052001,2.622146074,1.390748057,{"v":1.86569e-20,"d":"1.87E-20"},{"v":3.06987e-20,"d":"3.07E-20"},"up","yes","Dner","protein_coding","chr9:85586987-85902637:-","gi|149016288|gb|EDL75534.1|",3605,0,"rCG23980, isoform CRA_a [Rattus norvegicus]","gi|672024220|ref|XM_008758063.1|",2892,0,"PREDICTED: Rattus norvegicus delta/notch-like EGF repeat containing (Dner), transcript variant X1, mRNA","Q8JZM4",1358,0,"Delta and Notch-like epidermal growth factor-related receptor",".",".",".",".","pfam06247","Plasmod_Pvs28","Plasmodium ookinete surface protein Pvs28. This family consists of several ookinete surface protein (Pvs28) from several species of Plasmodium. Pvs25 and Pvs28 are expressed on the surface of ookinetes. These proteins are potential candidates for vaccine and induce antibodies that block the infectivity of Plasmodium vivax in immunised animals.","GO:0007220|Notch receptor processing;GO:0007417|central nervous system development;GO:0010001|glial cell differentiation;GO:0048741|skeletal muscle fiber development;","GO:0005769|early endosome;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0043025|neuronal cell body;","GO:0005112|Notch binding;GO:0005509|calcium ion binding;","K24463","DNER; delta and Notch-like epidermal growth factor-related receptor"]
["ENSRNOG00000020622",170,10.93617449,40,2.582474386,4.234765909,2.082282222,{"v":1.89944e-20,"d":"1.90E-20"},{"v":3.1227E-20,"d":"3.12E-20"},"up","yes","Cilp2","protein_coding","chr16:19539706-19547191:+","gi|157822257|ref|NP_001100777.1|",5683,0,"cartilage intermediate layer protein 2 precursor [Rattus norvegicus]","gi|157822256|ref|NM_001107307.1|",4081,0,"Rattus norvegicus cartilage intermediate layer protein 2 (Cilp2), mRNA","D3Z7H8",2004,0,"Cartilage intermediate layer protein 2",".",".",".",".","pfam13330","Mucin2_WxxW","Mucin-2 protein WxxW repeating region. This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in a member from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.","GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0003674|molecular_function;","K24436","CILP; cartilage intermediate layer protein"]
["ENSRNOG00000028616",90,5.789739437,6,0.387371158,14.94623262,3.901709976,{"v":3.01029E-20,"d":"3.01E-20"},{"v":4.91922e-20,"d":"4.92E-20"},"up","yes","Pck1","protein_coding","chr3:161930256-161936191:+","gi|158430173|pdb|2QF2|A",3273,0,"Chain A, Rat Cytosolic Pepck In Complex With Oxaloacetic Acid And Gdp.","gi|61835220|ref|NM_198780.3|",2621,0,"Rattus norvegicus phosphoenolpyruvate carboxykinase 1 (Pck1), mRNA","P07379",1264,0,"Phosphoenolpyruvate carboxykinase, cytosolic [GTP]","CPn0851",622,0,"COG1274","pfam00821","PEPCK","Phosphoenolpyruvate carboxykinase. Catalyses the formation of phosphoenolpyruvate by decarboxylation of oxaloacetate.","GO:0006006|glucose metabolic process;GO:0006094|gluconeogenesis;GO:0006107|oxaloacetate metabolic process;GO:0006165|nucleoside diphosphate phosphorylation;GO:0006629|lipid metabolic process;GO:0007568|aging;GO:0009617|response to bacterium;GO:0014823|response to activity;GO:0018105|peptidyl-serine phosphorylation;GO:0019543|propionate catabolic process;GO:0032496|response to lipopolysaccharide;GO:0032868|response to insulin;GO:0032869|cellular response to insulin stimulus;GO:0033993|response to lipid;GO:0042593|glucose homeostasis;GO:0042594|response to starvation;GO:0043382|positive regulation of memory T cell differentiation;GO:0046327|glycerol biosynthetic process from pyruvate;GO:0046890|regulation of lipid biosynthetic process;GO:0051365|cellular response to potassium ion starvation;GO:0061402|positive regulation of transcription from RNA polymerase II promoter in response to acidic pH;GO:0070365|hepatocyte differentiation;GO:0070741|response to interleukin-6;GO:0071300|cellular response to retinoic acid;GO:0071320|cellular response to cAMP;GO:0071332|cellular response to fructose stimulus;GO:0071333|cellular response to glucose stimulus;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071377|cellular response to glucagon stimulus;GO:0071456|cellular response to hypoxia;GO:0071549|cellular response to dexamethasone stimulus;GO:1904640|response to methionine;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;","GO:0000287|magnesium ion binding;GO:0004550|nucleoside diphosphate kinase activity;GO:0004611|phosphoenolpyruvate carboxykinase activity;GO:0004613|phosphoenolpyruvate carboxykinase (GTP) activity;GO:0005525|GTP binding;GO:0019003|GDP binding;GO:0030145|manganese ion binding;GO:0031406|carboxylic acid binding;","K01596","E4.1.1.32, pckA, PCK; phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32]"]
["ENSRNOG00000003841",367,23.60927081,158,10.20077383,2.314458807,1.210674885,{"v":3.31786e-20,"d":"3.32E-20"},{"v":5.41564e-20,"d":"5.42E-20"},"up","yes","Kcnh1","protein_coding","chr13:103722245-104024740:+","gi|149041059|gb|EDL95016.1|",5029,0,"potassium voltage-gated channel, subfamily H (eag-related), member 1, isoform CRA_a [Rattus norvegicus]","gi|755496542|ref|XR_373887.2|",3592,0,"PREDICTED: Mus musculus potassium voltage-gated channel, subfamily H (eag-related), member 1 (Kcnh1), transcript variant X1, misc_RNA","Q60603",1919,0,"Potassium voltage-gated channel subfamily H member 1","CC0285_1",76.3,{"v":5e-14,"d":"5.00E-14"},"COG2202","pfam13426","PAS_9","PAS domain.","GO:0001964|startle response;GO:0034220|ion transmembrane transport;GO:0034765|regulation of ion transmembrane transport;GO:0042127|regulation of cell proliferation;GO:0042391|regulation of membrane potential;GO:0048015|phosphatidylinositol-mediated signaling;GO:0071277|cellular response to calcium ion;GO:0071805|potassium ion transmembrane transport;GO:0099505|regulation of presynaptic membrane potential;GO:0099509|regulation of presynaptic cytosolic calcium ion concentration;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0005637|nuclear inner membrane;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0008076|voltage-gated potassium channel complex;GO:0009986|cell surface;GO:0030424|axon;GO:0030425|dendrite;GO:0030673|axolemma;GO:0031901|early endosome membrane;GO:0034705|potassium channel complex;GO:0042734|presynaptic membrane;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0043231|intracellular membrane-bounded organelle;GO:0045202|synapse;GO:0048471|perinuclear region of cytoplasm;GO:0098688|parallel fiber to Purkinje cell synapse;GO:0098839|postsynaptic density membrane;GO:0099056|integral component of presynaptic membrane;","GO:0005249|voltage-gated potassium channel activity;GO:0005251|delayed rectifier potassium channel activity;GO:0005515|protein binding;GO:0005516|calmodulin binding;GO:0019901|protein kinase binding;GO:0042802|identical protein binding;GO:0044325|ion channel binding;GO:0044877|protein-containing complex binding;GO:0071889|14-3-3 protein binding;GO:0099508|voltage-gated ion channel activity involved in regulation of presynaptic membrane potential;GO:1902936|phosphatidylinositol bisphosphate binding;","K04904","KCNH1, KV10.1; potassium voltage-gated channel Eag-related subfamily H member 1"]
["ENSRNOG00000062470",420,27.01878404,194,12.52500077,2.157188213,1.109152056,{"v":4.12378e-20,"d":"4.12E-20"},{"v":6.71194e-20,"d":"6.71E-20"},"up","yes","ENSRNOG00000062470","lncRNA","chr18:76385516-76386517:-",".",".",".",".","gi|672083299|ref|XM_008772100.1|",1002,0,"PREDICTED: Rattus norvegicus zinc finger protein 516 (Zfp516), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam07666","MpPF26","M penetrans paralogue family 26. These proteins include those ascribed to M penetrans paralogue family 26 in.",".",".",".",".","."]
["ENSRNOG00000015768",108,6.947687324,13,0.839304176,8.277913451,3.049267165,{"v":5.77442e-20,"d":"5.77E-20"},{"v":9.35588e-20,"d":"9.36E-20"},"up","yes","Nat8f5","protein_coding","chr4:118260252-118285704:-","gi|198278521|ref|NP_543160.1|",1047,{"v":9e-136,"d":"9.00E-136"},"probable N-acetyltransferase CML5 [Rattus norvegicus]","gi|198278520|ref|NM_080884.1|",1191,0,"Rattus norvegicus N-acetyltransferase 8 (GCN5-related) family member 5 (Nat8f5), mRNA","Q9QXS7",375,{"v":1e-124,"d":"1.00E-124"},"Probable N-acetyltransferase CML5",".",".",".",".","pfam00583","Acetyltransf_1","Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.","GO:0001702|gastrulation with mouth forming second;GO:0007368|determination of left/right symmetry;GO:0007507|heart development;","GO:0016021|integral component of membrane;","GO:0008080|N-acetyltransferase activity;","K20838","NAT8; N-acetyltransferase 8 [EC:2.3.1.80 2.3.1.-]"]
["ENSRNOG00000012314",485,31.20026252,240,15.49484632,2.013589672,1.009769722,{"v":6.14876e-20,"d":"6.15E-20"},{"v":9.95393e-20,"d":"9.95E-20"},"up","yes","Slirp","protein_coding","chr6:107088403-107097791:+","gi|157824057|ref|NP_001102977.1|",588,{"v":1e-67,"d":"1.00E-67"},"SRA stem-loop-interacting RNA-binding protein, mitochondrial [Rattus norvegicus]","gi|157824056|ref|NM_001109507.1|",2780,0,"Rattus norvegicus SRA stem-loop interacting RNA binding protein (Slirp), mRNA","Q9D8T7",209,{"v":2e-61,"d":"2.00E-61"},"SRA stem-loop-interacting RNA-binding protein, mitochondrial",".",".",".",".","pfam14259","RRM_6","RNA recognition motif (a.k.a. RRM, RBD, or RNP domain).","GO:0000961|negative regulation of mitochondrial RNA catabolic process;GO:0007286|spermatid development;GO:0007338|single fertilization;GO:0030317|flagellated sperm motility;GO:0070584|mitochondrion morphogenesis;","GO:0001669|acrosomal vesicle;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0036126|sperm flagellum;GO:0048471|perinuclear region of cytoplasm;GO:1990904|ribonucleoprotein complex;","GO:0003723|RNA binding;","K25095","SLIRP; SRA stem-loop-interacting RNA-binding protein, mitochondrial"]
["ENSRNOG00000005964",209,13.44506158,62,4.002835299,3.358884535,1.747982202,{"v":6.19956e-20,"d":"6.20E-20"},{"v":1.00333E-19,"d":"1.00E-19"},"up","yes","Nr4a3","protein_coding","chr5:62361822-62402733:+","gi|672052568|ref|XP_008761925.1|",2752,0,"PREDICTED: nuclear receptor subfamily 4 group A member 3 isoform X2 [Rattus norvegicus]","gi|82393808|gb|DQ268830.1|",5368,0,"Rattus norvegicus neuron-derived orphan receptor 1 mRNA, complete cds","P51179",1009,0,"Nuclear receptor subfamily 4 group A member 3",".",".",".",".","pfam00105","zf-C4","Zinc finger, C4 type (two domains). In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001707|mesoderm formation;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007369|gastrulation;GO:0007411|axon guidance;GO:0009444|pyruvate oxidation;GO:0010613|positive regulation of cardiac muscle hypertrophy;GO:0010828|positive regulation of glucose transmembrane transport;GO:0021766|hippocampus development;GO:0030522|intracellular receptor signaling pathway;GO:0030534|adult behavior;GO:0031100|animal organ regeneration;GO:0032765|positive regulation of mast cell cytokine production;GO:0035726|common myeloid progenitor cell proliferation;GO:0038097|positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway;GO:0042472|inner ear morphogenesis;GO:0042542|response to hydrogen peroxide;GO:0043066|negative regulation of apoptotic process;GO:0043303|mast cell degranulation;GO:0043434|response to peptide hormone;GO:0043524|negative regulation of neuron apoptotic process;GO:0044320|cellular response to leptin stimulus;GO:0045333|cellular respiration;GO:0045444|fat cell differentiation;GO:0045787|positive regulation of cell cycle;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046321|positive regulation of fatty acid oxidation;GO:0048008|platelet-derived growth factor receptor signaling pathway;GO:0048660|regulation of smooth muscle cell proliferation;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0048752|semicircular canal morphogenesis;GO:0050679|positive regulation of epithelial cell proliferation;GO:0050885|neuromuscular process controlling balance;GO:0060005|vestibular reflex;GO:0061469|regulation of type B pancreatic cell proliferation;GO:0071376|cellular response to corticotropin-releasing hormone stimulus;GO:0071870|cellular response to catecholamine stimulus;GO:0097009|energy homeostasis;GO:1900625|positive regulation of monocyte aggregation;GO:1903204|negative regulation of oxidative stress-induced neuron death;GO:1903208|negative regulation of hydrogen peroxide-induced neuron death;GO:1904707|positive regulation of vascular smooth muscle cell proliferation;GO:1904754|positive regulation of vascular associated smooth muscle cell migration;GO:2000108|positive regulation of leukocyte apoptotic process;GO:2000253|positive regulation of feeding behavior;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001223|transcription coactivator binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0004879|nuclear receptor activity;GO:0005515|protein binding;GO:0008270|zinc ion binding;GO:0019901|protein kinase binding;GO:0035035|histone acetyltransferase binding;GO:0035259|glucocorticoid receptor binding;GO:0035497|cAMP response element binding;GO:0042803|protein homodimerization activity;GO:0043565|sequence-specific DNA binding;","K08559","NR4A3, NOR1; nuclear receptor subfamily 4 group A member 3"]
["ENSRNOG00000016135",478,30.74994945,236,15.23659888,2.018163614,1.013043139,{"v":9.0558e-20,"d":"9.06E-20"},{"v":1.45815E-19,"d":"1.46E-19"},"up","yes","Fars2","protein_coding","chr17:28319280-28746337:-","gi|672081501|ref|XP_008769799.1|",2393,0,"PREDICTED: phenylalanine--tRNA ligase, mitochondrial isoform X2 [Rattus norvegicus]","gi|672081500|ref|XM_008771577.1|",1738,0,"PREDICTED: Rattus norvegicus phenylalanyl-tRNA synthetase 2, mitochondrial (Fars2), transcript variant X7, mRNA","Q6AYQ3",836,0,"Phenylalanine--tRNA ligase, mitochondrial","SPCC736.03c_1",232,{"v":7e-69,"d":"7.00E-69"},"COG0016","pfam01409","tRNA-synt_2d","tRNA synthetases class II core domain (F). Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only phenylalanyl-tRNA synthetases. This is the core catalytic domain.","GO:0006432|phenylalanyl-tRNA aminoacylation;GO:0008033|tRNA processing;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005759|mitochondrial matrix;","GO:0000049|tRNA binding;GO:0004826|phenylalanine-tRNA ligase activity;GO:0005524|ATP binding;","K01889","FARSA, pheS; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]"]
["ENSRNOG00000037206",373,23.99525344,164,10.58814498,2.26623771,1.180299196,{"v":9.20349e-20,"d":"9.20E-20"},{"v":1.48151E-19,"d":"1.48E-19"},"up","yes","Ccdc77","protein_coding","chr4:153534187-153566545:-","gi|564348683|ref|XP_006237298.1|",2763,0,"PREDICTED: coiled-coil domain-containing protein 77 isoform X2 [Rattus norvegicus]","gi|672050858|ref|XM_006237236.2|",2685,0,"PREDICTED: Rattus norvegicus coiled-coil domain containing 77 (Ccdc77), transcript variant X1, mRNA","Q9CZH8",757,0,"Coiled-coil domain-containing protein 77",".",".",".",".","pfam02375","JmjN","jmjN domain.",".","GO:0005813|centrosome;",".","K16757","CCDC77; coiled-coil domain-containing protein 77"]
["ENSRNOG00000017286",377,24.2525752,167,10.78183056,2.249393093,1.169535801,{"v":1.0844e-19,"d":"1.08E-19"},{"v":1.7402e-19,"d":"1.74E-19"},"up","yes","Ephx2","protein_coding","chr15:40289902-40327615:-","gi|55716049|gb|AAH85732.1|",2548,0,"Epoxide hydrolase 2, cytoplasmic [Rattus norvegicus]","gi|55716048|gb|BC085732.1|",950,0,"Rattus norvegicus epoxide hydrolase 2, cytoplasmic, mRNA (cDNA clone MGC:93421 IMAGE:7188942), complete cds","P80299",979,0,"Bifunctional epoxide hydrolase 2",".",".",".",".","pfam13419","HAD_2","Haloacid dehalogenase-like hydrolase.","GO:0002539|prostaglandin production involved in inflammatory response;GO:0006954|inflammatory response;GO:0009636|response to toxic substance;GO:0010628|positive regulation of gene expression;GO:0016311|dephosphorylation;GO:0019233|sensory perception of pain;GO:0042632|cholesterol homeostasis;GO:0043651|linoleic acid metabolic process;GO:0045777|positive regulation of blood pressure;GO:0046272|stilbene catabolic process;GO:0046839|phospholipid dephosphorylation;GO:0090181|regulation of cholesterol metabolic process;GO:0097176|epoxide metabolic process;","GO:0005777|peroxisome;GO:0005829|cytosol;","GO:0000287|magnesium ion binding;GO:0004301|epoxide hydrolase activity;GO:0015643|toxic substance binding;GO:0016787|hydrolase activity;GO:0016791|phosphatase activity;GO:0033885|10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity;GO:0042577|lipid phosphatase activity;GO:0042803|protein homodimerization activity;GO:0052642|lysophosphatidic acid phosphatase activity;","K08726","EPHX2; soluble epoxide hydrolase / lipid-phosphate phosphatase [EC:3.3.2.10 3.1.3.76]"]
["ENSRNOG00000024008",227,14.60300947,73,4.713015755,3.098442744,1.631543309,{"v":1.1584e-19,"d":"1.16E-19"},{"v":1.85686E-19,"d":"1.86E-19"},"up","yes","Cdc25c","protein_coding","chr18:26335834-26356185:-","gi|564393060|ref|XP_006254641.1|",2351,0,"PREDICTED: M-phase inducer phosphatase 3 isoform X1 [Rattus norvegicus]","gi|672083039|ref|XM_008772039.1|",1620,0,"PREDICTED: Rattus norvegicus cell division cycle 25C (Cdc25c), transcript variant X2, mRNA","P48967",763,0,"M-phase inducer phosphatase 3","SPAC24H6.05",137,{"v":2e-33,"d":"2.00E-33"},"COG5105","pfam06617","M-inducer_phosp","M-phase inducer phosphatase. This family represents a region within eukaryotic M-phase inducer phosphatases (EC:3.1.3.48), which also contain the pfam00581 domain. These proteins are involved in the control of mitosis.","GO:0000086|G2/M transition of mitotic cell cycle;GO:0007283|spermatogenesis;GO:0010971|positive regulation of G2/M transition of mitotic cell cycle;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0051301|cell division;GO:0110032|positive regulation of G2/MI transition of meiotic cell cycle;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005758|mitochondrial intermembrane space;GO:0016607|nuclear speck;GO:0048471|perinuclear region of cytoplasm;","GO:0004725|protein tyrosine phosphatase activity;GO:0005515|protein binding;GO:0019901|protein kinase binding;GO:0050699|WW domain binding;","K05867","CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]"]
["ENSRNOG00000069705",190,12.22278326,53,3.421778562,3.572055595,1.836754534,{"v":1.91174E-19,"d":"1.91E-19"},{"v":3.04308e-19,"d":"3.04E-19"},"up","yes","ENSRNOG00000069705","lncRNA","chr16:46842387-46854011:-","gi|73532753|ref|NP_001020228.2|",177,{"v":2e-11,"d":"2.00E-11"},"uncharacterized protein LOC502176 [Rattus norvegicus]","gi|959093084|ref|NG_046269.1|",482,0,"Rattus norvegicus Y-linked testis-specific protein 1-like (LOC103694772) pseudogene on chromosome Y",".",".",".",".",".",".",".",".","pfam10110","GPDPase_memb","Membrane domain of glycerophosphoryl diester phosphodiesterase. Members of this family comprise the membrane domain of the prokaryotic enzyme glycerophosphoryl diester phosphodiesterase.",".",".",".",".","."]
["ENSRNOG00000013371",98,6.304382942,10,0.645618597,9.764871978,3.28760113,{"v":1.95712e-19,"d":"1.96E-19"},{"v":3.11184e-19,"d":"3.11E-19"},"up","yes","ENSRNOG00000013371","protein_coding","chr3:142381374-142395308:+","gi|564343773|ref|XP_006235379.1|",2300,0,"PREDICTED: BPI fold-containing family B member 6 isoform X1 [Rattus norvegicus]","gi|564343772|ref|XM_006235317.1|",1520,0,"PREDICTED: Rattus norvegicus BPI fold containing family B, member 6 (Bpifb6), transcript variant X1, mRNA","Q8BU51",810,0,"BPI fold-containing family B member 6",".",".",".",".","pfam01273","LBP_BPI_CETP","LBP / BPI / CETP family, N-terminal domain. The N and C terminal domains of the LBP/BPI/CETP family are structurally similar.",".","GO:0005576|extracellular region;","GO:0008289|lipid binding;",".","."]
["ENSRNOG00000011213",321,20.65007066,132,8.522165474,2.423101349,1.276854748,{"v":2.73395e-19,"d":"2.73E-19"},{"v":4.32892e-19,"d":"4.33E-19"},"up","yes","Blm","protein_coding","chr1:134409857-134484312:-","gi|564329133|ref|XP_006229520.1|",6630,0,"PREDICTED: Bloom syndrome protein isoform X4 [Rattus norvegicus]","gi|672037352|ref|XM_006229458.2|",4618,0,"PREDICTED: Rattus norvegicus Bloom syndrome, RecQ helicase-like (Blm), transcript variant X4, mRNA","O88700",2170,0,"Bloom syndrome protein homolog","SPAC2G11.12",423,{"v":3e-123,"d":"3.00E-123"},"COG0514","pfam00270","DEAD","DEAD/DEAH box helicase. Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolizm, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.","GO:0000079|regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0000723|telomere maintenance;GO:0000724|double-strand break repair via homologous recombination;GO:0000729|DNA double-strand break processing;GO:0006260|DNA replication;GO:0006268|DNA unwinding involved in DNA replication;GO:0006281|DNA repair;GO:0006310|DNA recombination;GO:0006974|cellular response to DNA damage stimulus;GO:0007095|mitotic G2 DNA damage checkpoint;GO:0008150|biological_process;GO:0010165|response to X-ray;GO:0031297|replication fork processing;GO:0032508|DNA duplex unwinding;GO:0044806|G-quadruplex DNA unwinding;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045910|negative regulation of DNA recombination;GO:0045950|negative regulation of mitotic recombination;GO:0046632|alpha-beta T cell differentiation;GO:0046641|positive regulation of alpha-beta T cell proliferation;GO:0051098|regulation of binding;GO:0051259|protein complex oligomerization;GO:0051260|protein homooligomerization;GO:0051276|chromosome organization;GO:0051782|negative regulation of cell division;GO:0061820|telomeric D-loop disassembly;GO:0070244|negative regulation of thymocyte apoptotic process;GO:0071466|cellular response to xenobiotic stimulus;GO:0071479|cellular response to ionizing radiation;GO:0072711|cellular response to hydroxyurea;GO:0072757|cellular response to camptothecin;GO:0090329|regulation of DNA-dependent DNA replication;GO:1905168|positive regulation of double-strand break repair via homologous recombination;GO:1990414|replication-born double-strand break repair via sister chromatid exchange;","GO:0000228|nuclear chromosome;GO:0000781|chromosome, telomeric region;GO:0000800|lateral element;GO:0001673|male germ cell nucleus;GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005657|replication fork;GO:0005694|chromosome;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016363|nuclear matrix;GO:0016605|PML body;GO:0032991|protein-containing complex;GO:0045120|pronucleus;","GO:0000400|four-way junction DNA binding;GO:0000403|Y-form DNA binding;GO:0000405|bubble DNA binding;GO:0002039|p53 binding;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0003678|DNA helicase activity;GO:0003697|single-stranded DNA binding;GO:0004386|helicase activity;GO:0005524|ATP binding;GO:0008094|DNA-dependent ATPase activity;GO:0008270|zinc ion binding;GO:0009378|four-way junction helicase activity;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0043138|3'-5' DNA helicase activity;GO:0051880|G-quadruplex DNA binding;GO:0061749|forked DNA-dependent helicase activity;GO:0061821|telomeric D-loop binding;GO:1905773|8-hydroxy-2'-deoxyguanosine DNA binding;GO:1990814|DNA/DNA annealing activity;","K10901","BLM, RECQL3, SGS1; bloom syndrome protein [EC:5.6.2.4]"]
["ENSRNOG00000069674",158,10.16420923,37,2.388788807,4.254963521,2.089146763,{"v":3.44212e-19,"d":"3.44E-19"},{"v":5.43217e-19,"d":"5.43E-19"},"up","yes","ENSRNOG00000069674","lncRNA","chr10:54884768-54921688:-","gi|74138308|dbj|BAE38023.1|",216,{"v":6e-17,"d":"6.00E-17"},"unnamed protein product [Mus musculus]","gi|47777619|gb|AC147563.4|",642,0,"Mus musculus BAC clone RP23-231H21 from chromosome 10, complete sequence",".",".",".",".",".",".",".",".","pfam15103","G0-G1_switch_2","G0/G1 switch protein 2. This family of proteins regulate apoptosis by binding to Bcl-2 and preventing the formation of the anti-apoptotic BAX-BCL2 heterodimers.",".",".",".",".","."]
["ENSRNOG00000002474",379,24.38123607,171,11.040078,2.208429693,1.143020904,{"v":3.93554e-19,"d":"3.94E-19"},{"v":6.19716e-19,"d":"6.20E-19"},"up","yes","Tom1l1","protein_coding","chr10:75464577-75508250:-","gi|197246515|gb|AAI69112.1|",2409,0,"Unknown (protein for IMAGE:7131236) [Rattus norvegicus]","gi|359718965|ref|NM_001253859.1|",2233,0,"Rattus norvegicus target of myb1 like 1 membrane trafficking protein (Tom1l1), mRNA","F1LM81",927,0,"TOM1-like protein 1",".",".",".",".","pfam03127","GAT","GAT domain. The GAT domain is responsible for binding of GGA proteins to several members of the ARF family including ARF1 and ARF3. The GAT domain stabilizes membrane bound ARF1 in its GTP bound state, by interfering with GAP proteins.","GO:0006886|intracellular protein transport;GO:0007165|signal transduction;GO:0015031|protein transport;GO:0031954|positive regulation of protein autophosphorylation;GO:0032147|activation of protein kinase activity;GO:0045839|negative regulation of mitotic nuclear division;","GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005795|Golgi stack;GO:0005829|cytosol;GO:0010008|endosome membrane;GO:0016020|membrane;","GO:0017124|SH3 domain binding;GO:0019901|protein kinase binding;GO:0030276|clathrin binding;GO:0030295|protein kinase activator activity;GO:0035091|phosphatidylinositol binding;GO:0043130|ubiquitin binding;",".","."]
["ENSRNOG00000011167",430,27.66208842,206,13.29974309,2.079896449,1.056511703,{"v":4.12619e-19,"d":"4.13E-19"},{"v":6.49558e-19,"d":"6.50E-19"},"up","yes","Wdhd1","protein_coding","chr15:20489291-20523096:-","gi|564385757|ref|XP_006251857.1|",5857,0,"PREDICTED: WD repeat and HMG-box DNA-binding protein 1 isoform X1 [Rattus norvegicus]","gi|672077517|ref|XM_006251795.2|",4220,0,"PREDICTED: Rattus norvegicus WD repeat and HMG-box DNA binding protein 1 (Wdhd1), transcript variant X1, mRNA","P59328",2033,0,"WD repeat and HMG-box DNA-binding protein 1",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.","GO:0000278|mitotic cell cycle;GO:0006261|DNA-dependent DNA replication;GO:0006281|DNA repair;GO:0006396|RNA processing;GO:0033044|regulation of chromosome organization;","GO:0000775|chromosome, centromeric region;GO:0005654|nucleoplasm;GO:0043596|nuclear replication fork;","GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003723|RNA binding;GO:0070063|RNA polymerase binding;","K11274","WDHD1, CTF4; chromosome transmission fidelity protein 4"]
["ENSRNOG00000028541",91,5.854069875,8,0.516494877,11.3342264,3.502614021,{"v":4.77534e-19,"d":"4.78E-19"},{"v":7.50714e-19,"d":"7.51E-19"},"up","yes","Btnl2","protein_coding","chr20:4489517-4503341:-","gi|258679494|ref|NP_446267.1|",2618,0,"butyrophilin-like protein 2 [Rattus norvegicus]","gi|258679493|ref|NM_053815.1|",1542,0,"Rattus norvegicus butyrophilin-like 2 (Btnl2), mRNA","Q6MG97",929,0,"Butyrophilin-like protein 2",".",".",".",".","pfam08205","C2-set_2","CD80-like C2-set immunoglobulin domain. These domains belong to the immunoglobulin superfamily.","GO:0001817|regulation of cytokine production;GO:0008150|biological_process;GO:0032743|positive regulation of interleukin-2 production;GO:0042102|positive regulation of T cell proliferation;GO:0050852|T cell receptor signaling pathway;GO:0050860|negative regulation of T cell receptor signaling pathway;","GO:0005575|cellular_component;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0005102|signaling receptor binding;",".","."]
["ENSRNOG00000008728",202,12.99474851,61,3.938273439,3.299605453,1.722293526,{"v":5.9027e-19,"d":"5.90E-19"},{"v":9.24633e-19,"d":"9.25E-19"},"up","yes","Unc79","protein_coding","chr6:122080308-122327591:+","gi|564357097|ref|XP_006240563.1|",13203,0,"PREDICTED: protein unc-79 homolog isoform X1 [Rattus norvegicus]","gi|404247478|ref|NM_001271253.1|",8311,0,"Rattus norvegicus unc-79 homolog (C. elegans) (Unc79), mRNA","Q0KK59",4739,0,"Protein unc-79 homolog",".",".",".",".","pfam14776","UNC-79","Cation-channel complex subunit UNC-79. This family is a component of a cation-channel complex.","GO:0030534|adult behavior;GO:0035264|multicellular organism growth;GO:0048149|behavioral response to ethanol;",".",".","K24014","UNC79; protein unc-79"]
["ENSRNOG00000068801",209,13.44506158,65,4.196520878,3.203859095,1.6798107,{"v":6.18343e-19,"d":"6.18E-19"},{"v":9.67547e-19,"d":"9.68E-19"},"up","yes","ENSRNOG00000068801","lncRNA","chr9:3501033-3507130:-",".",".",".",".","gi|42517252|gb|AC125140.3|",491,0,"Mus musculus chromosome 17 clone RP24-327D1, complete sequence",".",".",".",".",".",".",".",".","pfam15461","BCD","Beta-carotene 15,15'-dioxygenase. BCD is a family of bacterial and archaeal proteins is found in bacteria and archaea that catalyse or regulate the conversion of beta-carotene to retinal. Characterisation of BCD proteins shows them to cleave beta-carotene at its central double bond (15,15###) to yield two molecules of all-trans-retinal. However, the oxygen atom of retinal originated not from water but from molecular oxygen, suggesting that the enzyme was a beta-carotene 15,15###-dioxygenase, rather than a mono-oxygenase that catalyzes the same biochemical reaction.",".",".",".",".","."]
["ENSRNOG00000063437",376,24.18824476,170,10.97551614,2.203836653,1.140017296,{"v":6.41854e-19,"d":"6.42E-19"},{"v":1.00351E-18,"d":"1.00E-18"},"up","yes","ENSRNOG00000063437","protein_coding","chr9:80115077-80129504:+","gi|564369291|ref|XP_006245370.1|",3725,0,"PREDICTED: U3 small nucleolar RNA-associated protein 14 homolog B [Rattus norvegicus]","gi|672065925|ref|XM_006245308.2|",3723,0,"PREDICTED: Rattus norvegicus U3 small nucleolar RNA-associated protein 14 homolog B-like (LOC102551819), transcript variant X2, mRNA","Q6EJB6",1242,0,"U3 small nucleolar RNA-associated protein 14 homolog B","YML093w",135,{"v":7e-31,"d":"7.00E-31"},"COG5644","pfam04615","Utp14","Utp14 protein. This protein is found to be part of a large ribonucleoprotein complex containing the U3 snoRNA. Depletion of the Utp proteins impedes production of the 18S rRNA, indicating that they are part of the active pre-rRNA processing complex. This large RNP complex has been termed the small subunit (SSU) processome.",".",".",".",".","."]
["ENSRNOG00000070046",295,18.97747926,117,7.55373758,2.5123297,1.329025805,{"v":6.76536e-19,"d":"6.77E-19"},{"v":1.05658E-18,"d":"1.06E-18"},"up","yes","Cdc45","protein_coding","chr11:82185473-82210619:+","gi|157786756|ref|NP_001099336.1|",2808,0,"cell division control protein 45 homolog [Rattus norvegicus]","gi|672071687|ref|XM_008768866.1|",2105,0,"PREDICTED: Rattus norvegicus cell division cycle 45 (Cdc45), transcript variant X1, mRNA","Q9Z1X9",1041,0,"Cell division control protein 45 homolog",".",".",".",".","pfam02724","CDC45","CDC45-like protein. CDC45 is an essential gene required for initiation of DNA replication in S. cerevisiae, forming a complex with MCM5/CDC46. Homologues of CDC45 have been identified in human, mouse and smut fungus among others.",".",".",".",".","."]
["ENSRNOG00000004207",243,15.63229648,85,5.487758071,2.848576099,1.510240948,{"v":7.06172e-19,"d":"7.06E-19"},{"v":1.10166E-18,"d":"1.10E-18"},"up","yes","Eml5","protein_coding","chr6:118046655-118175831:-","gi|402692201|ref|NP_001003402.2|",10307,0,"echinoderm microtubule-associated protein-like 5 [Rattus norvegicus]","gi|402692200|ref|NM_001003402.2|",6526,0,"Rattus norvegicus echinoderm microtubule associated protein like 5 (Eml5), mRNA","Q6ED65",3945,0,"Echinoderm microtubule-associated protein-like 5",".",".",".",".","pfam03451","HELP","HELP motif. The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.",".","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005874|microtubule;","GO:0008017|microtubule binding;","K18597","EML5; echinoderm microtubule-associated protein-like 5"]
["ENSRNOG00000017521",172,11.06483537,45,2.905283684,3.808521497,1.929231039,{"v":7.37128e-19,"d":"7.37E-19"},{"v":1.14775e-18,"d":"1.15E-18"},"up","yes","Gpr55","protein_coding","chr9:86590885-86640613:-","gi|564311905|ref|XP_006226976.1|",1624,0,"PREDICTED: G-protein coupled receptor 55 isoform X2 [Rattus norvegicus]","gi|672024239|ref|XM_006226917.2|",2470,0,"PREDICTED: Rattus norvegicus G protein-coupled receptor 55 (Gpr55), transcript variant X4, mRNA","Q3UJF0",488,{"v":6e-165,"d":"6.00E-165"},"G-protein coupled receptor 55",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007202|activation of phospholipase C activity;GO:0035025|positive regulation of Rho protein signal transduction;GO:0038171|cannabinoid signaling pathway;GO:0045453|bone resorption;GO:0045671|negative regulation of osteoclast differentiation;GO:0051482|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;","GO:0005887|integral component of plasma membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004949|cannabinoid receptor activity;","K08413","GPR55; G protein-coupled receptor 55"]
["ENSRNOG00000046639",380,24.44556651,173,11.16920172,2.188658341,1.130046761,{"v":7.38925E-19,"d":"7.39E-19"},{"v":1.14993e-18,"d":"1.15E-18"},"up","yes","Itgae","protein_coding","chr10:57591753-57764093:+","gi|386781426|ref|NP_113956.2|",5471,0,"integrin alpha-E precursor [Rattus norvegicus]","gi|386781425|ref|NM_031768.2|",3084,0,"Rattus norvegicus integrin subunit alpha E (Itgae), mRNA","Q60677",1842,0,"Integrin alpha-E",".",".",".",".","pfam08441","Integrin_alpha2","Integrin alpha. This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.","GO:0007155|cell adhesion;GO:0007229|integrin-mediated signaling pathway;","GO:0005575|cellular_component;GO:0008305|integrin complex;GO:0009897|external side of plasma membrane;","GO:0003674|molecular_function;GO:0046872|metal ion binding;","K06524","ITGAE, CD103; integrin alpha E"]
["ENSRNOG00000022267",259,16.66158349,95,6.133376667,2.716543332,1.44177206,{"v":8.71655e-19,"d":"8.72E-19"},{"v":1.3528E-18,"d":"1.35E-18"},"up","yes","AABR07039334.1","protein_coding","chrX:68023294-68024825:+","gi|564322934|ref|XP_006227465.1|",1029,{"v":1E-139,"d":"1.00E-139"},"PREDICTED: polyadenylate-binding protein 1-like 2 [Rattus norvegicus]","gi|672032477|ref|XM_006227403.2|",612,0,"PREDICTED: Rattus norvegicus poly(A) binding protein, cytoplasmic 1-like 2A (Pabpc1l2a), mRNA","Q5JQF8",379,{"v":3e-133,"d":"3.00E-133"},"Polyadenylate-binding protein 1-like 2",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.",".",".",".","K13126","PABPC; polyadenylate-binding protein"]
["ENSRNOG00000020315",427,27.4690971,206,13.29974309,2.065385543,1.046411113,{"v":1.02223E-18,"d":"1.02E-18"},{"v":1.58348E-18,"d":"1.58E-18"},"up","yes","Taf13","protein_coding","chr2:196205243-196215878:+","gi|677462861|gb|KFQ52275.1|",516,{"v":6e-61,"d":"6.00E-61"},"Transcription initiation factor TFIID subunit 13, partial [Pelecanus crispus]","gi|746817453|ref|NR_130639.1|",855,0,"Rattus norvegicus TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor (Taf13), transcript variant 2, non-coding RNA","Q5R9W6",203,{"v":4e-62,"d":"4.00E-62"},"Transcription initiation factor TFIID subunit 13","SPCC1494.02c",80.5,{"v":4e-17,"d":"4.00E-17"},"COG5248","pfam02269","TFIID-18kDa","Transcription initiation factor IID, 18kD subunit. This family includes the Spt3 yeast transcription factors and the 18kD subunit from human transcription initiation factor IID (TFIID-18). Determination of the crystal structure reveals an atypical histone fold","GO:0006366|transcription by RNA polymerase II;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005669|transcription factor TFIID complex;GO:0005730|nucleolus;","GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0008022|protein C-terminus binding;GO:0017025|TBP-class protein binding;GO:0046982|protein heterodimerization activity;","K03127","TAF13; transcription initiation factor TFIID subunit 13"]
["ENSRNOG00000051405",124,7.976974335,22,1.420360912,5.616160136,2.489584072,{"v":1.15904e-18,"d":"1.16E-18"},{"v":1.792e-18,"d":"1.79E-18"},"up","yes","AABR07021465.1","protein_coding","chr13:68458411-68544172:-","gi|672027354|ref|XP_008761118.1|",4258,0,"PREDICTED: axonemal dynein light chain domain-containing protein 1 isoform X1 [Rattus norvegicus]","gi|755471695|ref|XM_011251715.1|",2153,0,"PREDICTED: Mus musculus axonemal dynein light chain domain containing 1 (Axdnd1), mRNA",".",".",".",".",".",".",".",".","pfam10211","Ax_dynein_light","Axonemal dynein light chain. Axonemal dynein light chain proteins play a dynamic role in flagellar and cilia motility. Eukaryotic cilia and flagella are complex organelles consisting of a core structure, the axoneme, which is composed of nine microtubule doublets forming a cylinder that surrounds a pair of central singlet microtubules. This ultra-structural arrangement seems to be one of the most stable micro-tubular assemblies known and is responsible for the flagellar and ciliary movement of a large number of organisms ranging from protozoan to mammals. This light chain interacts directly with the N-terminal half of the heavy chains.",".",".",".",".","."]
["ENSRNOG00000019582",282,18.14118357,110,7.101804562,2.55444703,1.35301102,{"v":1.35773e-18,"d":"1.36E-18"},{"v":2.09127e-18,"d":"2.09E-18"},"up","yes","Mthfd1l","protein_coding","chr1:40444008-40632905:+","gi|313151179|ref|NP_001101932.2|",4876,0,"monofunctional C1-tetrahydrofolate synthase, mitochondrial [Rattus norvegicus]","gi|313151178|ref|NM_001108462.2|",3522,0,"Rattus norvegicus methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (Mthfd1l), mRNA","Q3V3R1",1788,0,"Monofunctional C1-tetrahydrofolate synthase, mitochondrial","SPBC839.16_2",699,0,"COG2759","pfam01268","FTHFS","Formate--tetrahydrofolate ligase.","GO:0001843|neural tube closure;GO:0006760|folic acid-containing compound metabolic process;GO:0008150|biological_process;GO:0009257|10-formyltetrahydrofolate biosynthetic process;GO:0015942|formate metabolic process;GO:0035999|tetrahydrofolate interconversion;GO:0048702|embryonic neurocranium morphogenesis;GO:0048703|embryonic viscerocranium morphogenesis;","GO:0005575|cellular_component;GO:0005739|mitochondrion;GO:0005829|cytosol;","GO:0003674|molecular_function;GO:0004329|formate-tetrahydrofolate ligase activity;GO:0004488|methylenetetrahydrofolate dehydrogenase (NADP+) activity;GO:0005524|ATP binding;GO:0042803|protein homodimerization activity;","K13402","MTHFD1L; monofunctional C1-tetrahydrofolate synthase, mitochondrial [EC:6.3.4.3]"]
["ENSRNOG00000028330",143,9.19925266,31,2.001417649,4.596368311,2.200494407,{"v":1.3623e-18,"d":"1.36E-18"},{"v":2.09774e-18,"d":"2.10E-18"},"up","yes","AABR07067600.1","protein_coding","chr9:48763742-48764305:-","gi|507572163|ref|XP_004669676.1|",367,{"v":3e-53,"d":"3.00E-53"},"PREDICTED: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [Jaculus jaculus]","gi|480359913|gb|KC660101.1|",458,0,"Rattus norvegicus BCL2/adenovirus E1B interacting protein 3 variant (Bnip3) mRNA, complete cds, alternatively spliced","O55003",154,{"v":6e-46,"d":"6.00E-46"},"BCL2/adenovirus E1B 19 kDa protein-interacting protein 3",".",".",".",".","pfam06553","BNIP3","BNIP3. This family consists of several mammalian specific BCL2/adenovirus E1B 19-kDa protein-interacting protein 3 or BNIP3 sequences. BNIP3 belongs to the Bcl-2 homology 3 (BH3)-only family, a Bcl-2-related family possessing an atypical Bcl-2 homology 3 (BH3) domain, which regulates PCD from mitochondrial sites by selective Bcl-2/Bcl-XL interactions. BNIP3 family members contain a C-terminal transmembrane domain that is required for their mitochondrial localisation, homodimerization, as well as regulation of their pro-apoptotic activities. BNIP3-mediated apoptosis has been reported to be independent of caspase activation and cytochrome c release and is characterized by early plasma membrane and mitochondrial damage, prior to the appearance of chromatin condensation or DNA fragmentation.",".",".",".",".","."]
["ENSRNOG00000053640",408,26.24681878,194,12.52500077,2.095554264,1.06733188,{"v":1.71439E-18,"d":"1.71E-18"},{"v":2.62857E-18,"d":"2.63E-18"},"up","yes","Kcng2","protein_coding","chr18:73743074-73808723:-","gi|157817231|ref|NP_001100842.1|",1708,0,"potassium voltage-gated channel subfamily G member 2 [Rattus norvegicus]","gi|157817230|ref|NM_001107372.1|",1838,0,"Rattus norvegicus potassium voltage-gated channel modifier subfamily G member 2 (Kcng2), mRNA","Q9QYU3",662,0,"Potassium voltage-gated channel subfamily G member 2","mll3241_1",54.7,1e-07,"COG1226","pfam02214","BTB_2","BTB/POZ domain. In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.","GO:0034765|regulation of ion transmembrane transport;GO:0051260|protein homooligomerization;GO:0071805|potassium ion transmembrane transport;","GO:0008076|voltage-gated potassium channel complex;GO:0016021|integral component of membrane;","GO:0005249|voltage-gated potassium channel activity;","K04901","KCNG2, KV6.2; potassium voltage-gated channel subfamily G member 2"]
["ENSRNOG00000017473",331,21.29337504,142,9.167784071,2.322630515,1.215759668,{"v":1.72645E-18,"d":"1.73E-18"},{"v":2.64635e-18,"d":"2.65E-18"},"up","yes","Odad4","protein_coding","chr10:85480094-85508603:+","gi|157817049|ref|NP_001100519.1|",3025,0,"tetratricopeptide repeat protein 25 [Rattus norvegicus]","gi|672068683|ref|XM_006247310.2|",2215,0,"PREDICTED: Rattus norvegicus tetratricopeptide repeat domain 25 (Ttc25), transcript variant X1, mRNA","Q9D4B2",1004,0,"Tetratricopeptide repeat protein 25",".",".",".",".","pfam13414","TPR_11","TPR repeat.","GO:0003341|cilium movement;GO:0007420|brain development;GO:0007507|heart development;GO:0030324|lung development;GO:0036158|outer dynein arm assembly;GO:0060287|epithelial cilium movement involved in determination of left/right asymmetry;GO:0090660|cerebrospinal fluid circulation;","GO:0005576|extracellular region;GO:0005737|cytoplasm;GO:0005930|axoneme;GO:0097728|9+0 motile cilium;GO:0097729|9+2 motile cilium;",".","K24254","TTC25; tetratricopeptide repeat protein 25"]
["ENSRNOG00000009855",104,6.690365571,14,0.903866035,7.401943774,2.887904177,{"v":2.26032e-18,"d":"2.26E-18"},{"v":3.45633e-18,"d":"3.46E-18"},"up","yes","Serpina5","protein_coding","chr6:123023306-123028407:+","gi|347921897|ref|NP_075246.3|",1866,0,"plasma serine protease inhibitor isoform 2 precursor [Rattus norvegicus]","gi|347921896|ref|NM_022957.3|",2158,0,"Rattus norvegicus serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 (Serpina5), transcript variant 2, mRNA","P70458",610,0,"Plasma serine protease inhibitor","all0778",135,{"v":1e-33,"d":"1.00E-33"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0007283|spermatogenesis;GO:0010951|negative regulation of endopeptidase activity;GO:0045861|negative regulation of proteolysis;GO:0051346|negative regulation of hydrolase activity;GO:0061107|seminal vesicle development;","GO:0002080|acrosomal membrane;GO:0005615|extracellular space;GO:0009897|external side of plasma membrane;GO:0016020|membrane;GO:0031091|platelet alpha granule;GO:0031094|platelet dense tubular network;GO:0032991|protein-containing complex;GO:0036024|protein C inhibitor-TMPRSS7 complex;GO:0036025|protein C inhibitor-TMPRSS11E complex;GO:0036026|protein C inhibitor-PLAT complex;GO:0036027|protein C inhibitor-PLAU complex;GO:0036028|protein C inhibitor-thrombin complex;GO:0036029|protein C inhibitor-KLK3 complex;GO:0036030|protein C inhibitor-plasma kallikrein complex;GO:0070062|extracellular exosome;GO:0097181|protein C inhibitor-coagulation factor V complex;GO:0097182|protein C inhibitor-coagulation factor Xa complex;GO:0097183|protein C inhibitor-coagulation factor XI complex;","GO:0001972|retinoic acid binding;GO:0002020|protease binding;GO:0004867|serine-type endopeptidase inhibitor activity;GO:0031210|phosphatidylcholine binding;GO:0032190|acrosin binding;","K03913","SERPINA5, PCI; protein C inhibitor"]
["ENSRNOG00000007332",380,24.44556651,176,11.3628873,2.151351665,1.10524337,{"v":2.99695e-18,"d":"3.00E-18"},{"v":4.56563e-18,"d":"4.57E-18"},"up","yes","Sstr3","protein_coding","chr7:110092575-110099769:-","gi|19424168|ref|NP_598206.1|",1504,0,"somatostatin receptor type 3 [Rattus norvegicus]","gi|19424167|ref|NM_133522.1|",3826,0,"Rattus norvegicus somatostatin receptor 3 (Sstr3), mRNA","P30936",583,0,"Somatostatin receptor type 3",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007218|neuropeptide signaling pathway;GO:0007283|spermatogenesis;GO:0021549|cerebellum development;GO:0030900|forebrain development;GO:0038170|somatostatin signaling pathway;GO:0042594|response to starvation;GO:0060125|negative regulation of growth hormone secretion;GO:0071385|cellular response to glucocorticoid stimulus;GO:0071392|cellular response to estradiol stimulus;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005929|cilium;GO:0043005|neuron projection;GO:0060170|ciliary membrane;GO:0097730|non-motile cilium;","GO:0004930|G protein-coupled receptor activity;GO:0004994|somatostatin receptor activity;GO:0005102|signaling receptor binding;GO:0042277|peptide binding;GO:0042923|neuropeptide binding;","K04219","SSTR3; somatostatin receptor 3"]
["ENSRNOG00000061450",207,13.3164007,66,4.261082737,3.125121366,1.643912219,{"v":3.01119e-18,"d":"3.01E-18"},{"v":4.58609e-18,"d":"4.59E-18"},"up","yes","Homer2","protein_coding","chr1:135567414-135659772:-","gi|16758006|ref|NP_445761.1|",1876,0,"homer protein homolog 2 [Rattus norvegicus]","gi|16758005|ref|NM_053309.1|",1962,0,"Rattus norvegicus homer scaffolding protein 2 (Homer2), mRNA","O88801",727,0,"Homer protein homolog 2",".",".",".",".","pfam00568","WH1","WH1 domain. WASp Homology domain 1 (WH1) domain. WASP is the protein that is defective in Wiskott-Aldrich syndrome (WAS). The majority of point mutations occur within the amino- terminal WH1 domain. The metabotropic glutamate receptors mGluR1alpha and mGluR5 bind a protein called homer, which is a WH1 domain homologue. A subset of WH1 domains has been termed a \"EVH1\" domain and appear to bind a polyproline motif.","GO:0007216|G protein-coupled glutamate receptor signaling pathway;GO:0007605|sensory perception of sound;GO:0008277|regulation of G protein-coupled receptor signaling pathway;GO:0032703|negative regulation of interleukin-2 production;GO:0035584|calcium-mediated signaling using intracellular calcium source;GO:0048148|behavioral response to cocaine;GO:0048875|chemical homeostasis within a tissue;GO:0070885|negative regulation of calcineurin-NFAT signaling cascade;GO:2001256|regulation of store-operated calcium entry;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0030425|dendrite;GO:0032426|stereocilium tip;GO:0043025|neuronal cell body;GO:0043229|intracellular organelle;GO:0045177|apical part of cell;GO:0098978|glutamatergic synapse;","GO:0003779|actin binding;GO:0005515|protein binding;GO:0019904|protein domain specific binding;GO:0030160|GKAP/Homer scaffold activity;GO:0035254|glutamate receptor binding;GO:0035256|G protein-coupled glutamate receptor binding;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;","K15010","HOMER; homer"]
["ENSRNOG00000007061",219,14.08836596,73,4.713015755,2.989246524,1.579781881,{"v":3.12967E-18,"d":"3.13E-18"},{"v":4.764e-18,"d":"4.76E-18"},"up","yes","Arhgef33","protein_coding","chr6:14551495-14725292:-","gi|672020375|ref|XP_008774394.1|",4121,0,"PREDICTED: rho guanine nucleotide exchange factor 33 isoform X2 [Rattus norvegicus]","gi|672055234|ref|XM_008764442.1|",3022,0,"PREDICTED: Rattus norvegicus Rho guanine nucleotide exchange factor (GEF) 33 (Arhgef33), transcript variant X2, mRNA","Q8BW86",1451,0,"Rho guanine nucleotide exchange factor 33","PA4016_1",63.9,1e-09,"COG4642","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0050790|regulation of catalytic activity;",".","GO:0005085|guanyl-nucleotide exchange factor activity;",".","."]
["ENSRNOG00000042717",115,7.398000391,19,1.226675333,6.030935969,2.592381918,{"v":3.71908e-18,"d":"3.72E-18"},{"v":5.64314e-18,"d":"5.64E-18"},"up","yes","Ciart","protein_coding","chr2:183419819-183423313:-","gi|197385188|ref|NP_001128065.1|",1707,0,"circadian associated repressor of transcription [Rattus norvegicus]","gi|197385187|ref|NM_001134593.1|",1418,0,"Rattus norvegicus circadian associated repressor of transcription (Ciart), mRNA","Q3TQ03",600,0,"Circadian-associated transcriptional repressor",".",".",".",".","pfam15449","Retinal","Retinal protein. This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.","GO:0032922|circadian regulation of gene expression;GO:0045475|locomotor rhythm;GO:0045892|negative regulation of transcription, DNA-templated;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0070888|E-box binding;","K21599","CIART, CHRONO, GM129; circadian-associated transcriptional repressor"]
["ENSRNOG00000020013",307,19.74944452,128,8.263918036,2.38984032,1.256914226,{"v":4.18161e-18,"d":"4.18E-18"},{"v":6.33655e-18,"d":"6.34E-18"},"up","yes","Psrc1","protein_coding","chr2:196022361-196026874:+","gi|112983728|ref|NP_001037767.1|",1387,0,"proline/serine-rich coiled-coil protein 1 [Rattus norvegicus]","gi|672043837|ref|XM_006233177.2|",1643,0,"PREDICTED: Rattus norvegicus proline/serine-rich coiled-coil 1 (Psrc1), transcript variant X3, mRNA","Q3KR66",538,0,"Proline/serine-rich coiled-coil protein 1",".",".",".",".","pfam15259","GTSE1_N","G-2 and S-phase expressed 1. This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S phase-expressed-1) protein is specifically expressed during S and G2 phases of the cell cycle. It is mainly localized to the microtubules and when overexpressed delays the G2 to M transition. the full protein negatively regulates p53 transactivation function, protein levels, and p53-dependent apoptosis. This domain family is found in eukaryotes, and is approximately 140 amino acids in length. There is a conserved FDFD sequence motif.","GO:0001578|microtubule bundle formation;GO:0007080|mitotic metaphase plate congression;GO:0009987|cellular process;GO:0030308|negative regulation of cell growth;GO:0031116|positive regulation of microtubule polymerization;GO:0045737|positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045893|positive regulation of transcription, DNA-templated;GO:0051301|cell division;GO:0060236|regulation of mitotic spindle organization;","GO:0000922|spindle pole;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005819|spindle;GO:0005829|cytosol;GO:0005876|spindle microtubule;GO:0015630|microtubule cytoskeleton;GO:0030496|midbody;","GO:0008017|microtubule binding;","K21443","PSRC1; proline/serine-rich coiled-coil protein 1"]
["ENSRNOG00000002425",439,28.24106236,218,14.0744854,2.006543156,1.004712185,{"v":4.66089e-18,"d":"4.66E-18"},{"v":7.05534e-18,"d":"7.06E-18"},"up","yes","Pctp","protein_coding","chr10:74808887-74849867:-","gi|8393922|ref|NP_058921.1|",1141,{"v":6e-151,"d":"6.00E-151"},"phosphatidylcholine transfer protein [Rattus norvegicus]","gi|51259303|gb|BC078854.1|",1738,0,"Rattus norvegicus phosphatidylcholine transfer protein, mRNA (cDNA clone MGC:93515 IMAGE:7113616), complete cds","P53809",444,{"v":2e-152,"d":"2.00E-152"},"Phosphatidylcholine transfer protein",".",".",".",".","pfam01852","START","START domain.","GO:0008203|cholesterol metabolic process;GO:0015914|phospholipid transport;GO:0120163|negative regulation of cold-induced thermogenesis;","GO:0005829|cytosol;","GO:0008525|phosphatidylcholine transporter activity;GO:0031210|phosphatidylcholine binding;",".","."]
["ENSRNOG00000007590",194,12.48010501,60,3.873711579,3.221743476,1.687841627,{"v":8.49109e-18,"d":"8.49E-18"},{"v":1.27384E-17,"d":"1.27E-17"},"up","yes","Eya1","protein_coding","chr5:4955543-5101483:+","gi|537216149|gb|ERE81808.1|",2585,0,"putative eyes absent [Cricetulus griseus]","gi|672019010|ref|XM_006225171.2|",3552,0,"PREDICTED: Rattus norvegicus EYA transcriptional coactivator and phosphatase 1 (Eya1), transcript variant X5, mRNA","P97767",989,0,"Eyes absent homolog 1",".",".",".",".","pfam07223","DUF1421","Protein of unknown function (DUF1421). This family represents a conserved region approximately 350 residues long within a number of plant proteins of unknown function.",".",".",".",".","."]
["ENSRNOG00000010555",280,18.01252269,112,7.230928281,2.49103877,1.316747476,{"v":8.82262e-18,"d":"8.82E-18"},{"v":1.32254e-17,"d":"1.32E-17"},"up","yes","Phyhip","protein_coding","chr15:45533974-45545221:+","gi|77046155|gb|AAH30494.2|",1778,0,"Phyhip protein, partial [Mus musculus]","gi|672078624|ref|XM_008770837.1|",2776,0,"PREDICTED: Rattus norvegicus phytanoyl-CoA 2-hydroxylase interacting protein (Phyhip), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam00041","fn3","Fibronectin type III domain.","GO:0008104|protein localization;","GO:0005737|cytoplasm;","GO:1990782|protein tyrosine kinase binding;",".","."]
["ENSRNOG00000004708",96,6.175722066,12,0.774742316,7.971324064,2.994819381,{"v":1.21442E-17,"d":"1.21E-17"},{"v":1.80953E-17,"d":"1.81E-17"},"up","yes","Aard","protein_coding","chr7:83364204-83369317:+","gi|149066401|gb|EDM16274.1|",828,{"v":6e-105,"d":"6.00E-105"},"alanine and arginine rich domain containing protein [Rattus norvegicus]","gi|21489992|ref|NM_145093.1|",1244,0,"Rattus norvegicus alanine and arginine rich domain containing protein (Aard), mRNA","Q91ZF7",217,{"v":4e-66,"d":"4.00E-66"},"Alanine and arginine-rich domain-containing protein",".",".",".",".","pfam00429","TLV_coat","ENV polyprotein (coat polyprotein).","GO:0030324|lung development;","GO:0005575|cellular_component;","GO:0003674|molecular_function;",".","."]
["ENSRNOG00000047706",224,14.41001815,78,5.035825053,2.861500946,1.516772084,{"v":1.26223e-17,"d":"1.26E-17"},{"v":1.87881e-17,"d":"1.88E-17"},"up","yes","RT1-CE2","protein_coding","chr20:3537809-3541790:-","gi|57012402|ref|NP_001008840.1|",1652,0,"RT1 class I, locus CE2 precursor [Rattus norvegicus]","gi|110350025|gb|AC130591.5|",1653,0,"Rattus norvegicus BAC CH230-312A21 () complete sequence","P16391",528,{"v":2E-179,"d":"2.00E-179"},"RT1 class I histocompatibility antigen, AA alpha chain",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.",".",".",".",".","."]
["ENSRNOG00000006930",189,12.15845282,58,3.74458786,3.24694019,1.69908081,{"v":1.57962e-17,"d":"1.58E-17"},{"v":2.34574E-17,"d":"2.35E-17"},"up","yes","Casq1","protein_coding","chr13:84670649-84680339:-","gi|227430324|ref|NP_001153066.1|",1829,0,"calsequestrin-1 precursor [Rattus norvegicus]","gi|227430323|ref|NM_001159594.1|",1848,0,"Rattus norvegicus calsequestrin 1 (Casq1), mRNA","P19633",710,0,"Calsequestrin-1",".",".",".",".","pfam01216","Calsequestrin","Calsequestrin.","GO:0007029|endoplasmic reticulum organization;GO:0007519|skeletal muscle tissue development;GO:0009408|response to heat;GO:0010033|response to organic substance;GO:0010880|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0014809|regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion;GO:0014870|response to muscle inactivity;GO:0014894|response to denervation involved in regulation of muscle adaptation;GO:0045214|sarcomere organization;GO:0051258|protein polymerization;GO:0051279|regulation of release of sequestered calcium ion into cytosol;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;GO:0051282|regulation of sequestering of calcium ion;GO:1901341|positive regulation of store-operated calcium channel activity;GO:2001256|regulation of store-operated calcium entry;","GO:0005737|cytoplasm;GO:0005759|mitochondrial matrix;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0014802|terminal cisterna;GO:0014804|terminal cisterna lumen;GO:0016529|sarcoplasmic reticulum;GO:0030016|myofibril;GO:0030018|Z disc;GO:0030315|T-tubule;GO:0031674|I band;GO:0033017|sarcoplasmic reticulum membrane;GO:0033018|sarcoplasmic reticulum lumen;GO:0042383|sarcolemma;GO:0043231|intracellular membrane-bounded organelle;","GO:0005509|calcium ion binding;GO:0042802|identical protein binding;","K23468","CASQ1; calsequestrin 1"]
["ENSRNOG00000011376",180,11.57947887,53,3.421778562,3.384052669,1.758752022,{"v":1.60521e-17,"d":"1.61E-17"},{"v":2.38312E-17,"d":"2.38E-17"},"up","yes","Bbof1","protein_coding","chr6:104055241-104082071:+","gi|672056720|ref|XP_008763051.1|",2509,0,"PREDICTED: basal body-orientation factor 1 isoform X1 [Rattus norvegicus]","gi|672056719|ref|XM_008764829.1|",3158,0,"PREDICTED: Rattus norvegicus coiled-coil domain containing 176 (Ccdc176), transcript variant X1, mRNA","Q3V079",850,0,"Basal body-orientation factor 1","PA0747",89.7,{"v":3e-17,"d":"3.00E-17"},"COG1012","pfam14988","DUF4515","Domain of unknown function (DUF4515). This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 198 and 469 amino acids in length. There are two completely conserved L residues that may be functionally important.",".","GO:0005737|cytoplasm;GO:0036064|ciliary basal body;",".","K25473","BBOF1; basal body-orientation factor 1"]
["ENSRNOG00000001143",388,24.96021002,186,12.0085059,2.078544178,1.055573412,{"v":2.25446e-17,"d":"2.25E-17"},{"v":3.33056e-17,"d":"3.33E-17"},"up","yes","Cit","protein_coding","chr12:40605563-40763860:-","gi|564379703|ref|XP_006249533.1|",10291,0,"PREDICTED: citron Rho-interacting kinase isoform X5 [Rattus norvegicus]","gi|672073104|ref|XM_006249471.2|",6239,0,"PREDICTED: Rattus norvegicus citron rho-interacting serine/threonine kinase (Cit), transcript variant X5, mRNA","P49025",3838,0,"Citron Rho-interacting kinase",".",".",".",".","pfam00780","CNH","CNH domain. Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished observations.","GO:0000070|mitotic sister chromatid segregation;GO:0000086|G2/M transition of mitotic cell cycle;GO:0000278|mitotic cell cycle;GO:0000281|mitotic cytokinesis;GO:0001889|liver development;GO:0006468|protein phosphorylation;GO:0007030|Golgi organization;GO:0007091|metaphase/anaphase transition of mitotic cell cycle;GO:0007283|spermatogenesis;GO:0008064|regulation of actin polymerization or depolymerization;GO:0016358|dendrite development;GO:0032467|positive regulation of cytokinesis;GO:0035331|negative regulation of hippo signaling;GO:0035556|intracellular signal transduction;GO:0043086|negative regulation of catalytic activity;GO:0048699|generation of neurons;GO:0050774|negative regulation of dendrite morphogenesis;GO:0051402|neuron apoptotic process;","GO:0001726|ruffle;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005773|vacuole;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0015629|actin cytoskeleton;GO:0030496|midbody;GO:0031985|Golgi cisterna;GO:0032154|cleavage furrow;GO:0043025|neuronal cell body;","GO:0001223|transcription coactivator binding;GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;GO:0019901|protein kinase binding;GO:0030165|PDZ domain binding;GO:0030291|protein serine/threonine kinase inhibitor activity;GO:0046872|metal ion binding;GO:0097110|scaffold protein binding;","K16308","CIT; citron Rho-interacting kinase [EC:2.7.11.1]"]
["ENSRNOG00000021704",303,19.49212277,129,8.328479896,2.340417821,1.226766109,{"v":2.80496e-17,"d":"2.80E-17"},{"v":4.13526e-17,"d":"4.14E-17"},"up","yes","Atp8b5p","protein_coding","chr5:57506466-57620056:+","gi|672019256|ref|XP_008774160.1|",5941,0,"PREDICTED: phospholipid-transporting ATPase FetA isoform X2 [Rattus norvegicus]","gi|672019255|ref|XM_008775938.1|",4291,0,"PREDICTED: Rattus norvegicus ATPase, class I, type 8B, member 5, pseudogene (Atp8b5p), transcript variant X2, mRNA","A3FIN4",2161,0,"Phospholipid-transporting ATPase FetA","YAL026c",718,0,"COG0474","pfam13246","Hydrolase_like2","Putative hydrolase of sodium-potassium ATPase alpha subunit. This is a putative hydrolase of the sodium-potassium ATPase alpha subunit.","GO:0007030|Golgi organization;GO:0045332|phospholipid translocation;","GO:0001669|acrosomal vesicle;GO:0005802|trans-Golgi network;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0000287|magnesium ion binding;GO:0005524|ATP binding;GO:0090555|phosphatidylethanolamine-translocating ATPase activity;","K01530","E7.6.2.1; phospholipid-translocating ATPase [EC:7.6.2.1]"]
["ENSRNOG00000018415",286,18.39850532,118,7.618299439,2.415040977,1.272047668,{"v":2.90233e-17,"d":"2.90E-17"},{"v":4.27771E-17,"d":"4.28E-17"},"up","yes","Acot13","protein_coding","chr17:40240378-40252851:+","gi|157817043|ref|NP_001099581.1|",738,{"v":3e-96,"d":"3.00E-96"},"acyl-coenzyme A thioesterase 13 [Rattus norvegicus]","gi|157817042|ref|NM_001106111.1|",743,0,"Rattus norvegicus acyl-CoA thioesterase 13 (Acot13), mRNA","Q9CQR4",280,{"v":2e-94,"d":"2.00E-94"},"Acyl-coenzyme A thioesterase 13","SPBC31F10.02",85.9,{"v":1e-19,"d":"1.00E-19"},"COG2050","pfam03061","4HBT","Thioesterase superfamily. This family contains a wide variety of enzymes, principally thioesterases. This family includes 4HBT (EC 3.1.2.23) which catalyses the final step in the biosynthesis of 4-hydroxybenzoate from 4-chlorobenzoate in the soil dwelling microbe Pseudomonas CBS-3. This family includes various cytosolic long-chain acyl-CoA thioester hydrolases. Long-chain acyl-CoA hydrolases hydrolyse palmitoyl-CoA to CoA and palmitate, they also catalyse the hydrolysis of other long chain fatty acyl-CoA thioesters.","GO:0051289|protein homotetramerization;GO:0120163|negative regulation of cold-induced thermogenesis;","GO:0005739|mitochondrion;GO:0005759|mitochondrial matrix;","GO:0047617|acyl-CoA hydrolase activity;","K17362","ACOT13; acyl-coenzyme A thioesterase 13 [EC:3.1.2.-]"]
["ENSRNOG00000050072",278,17.88386182,113,7.295490141,2.451358506,1.293581491,{"v":3.14948E-17,"d":"3.15E-17"},{"v":4.636e-17,"d":"4.64E-17"},"up","yes","Jmjd7","protein_coding","chr3:106998477-107004538:+","gi|167900431|ref|NP_001108128.1|",1683,0,"jmjC domain-containing protein 7 [Rattus norvegicus]","gi|167900430|ref|NM_001114656.1|",1335,0,"Rattus norvegicus jumonji domain containing 7 (Jmjd7), mRNA","P0C872",639,0,"JmjC domain-containing protein 7",".",".",".",".","pfam13621","Cupin_8","Cupin-like domain. This cupin like domain shares similarity to the JmjC domain.","GO:0006508|proteolysis;GO:0018126|protein hydroxylation;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0004175|endopeptidase activity;GO:0004177|aminopeptidase activity;GO:0004497|monooxygenase activity;GO:0016706|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0035064|methylated histone binding;","K19219","JMJD7; peptidyl-lysine (3S)-dioxygenase / protease [EC:1.14.11.63 3.4.-.-]"]
["ENSRNOG00000048961",262,16.8545748,103,6.649871544,2.534571486,1.341741855,{"v":3.49172e-17,"d":"3.49E-17"},{"v":5.13051e-17,"d":"5.13E-17"},"up","yes","Bhlhe41","protein_coding","chr4:178834271-178838468:-","gi|20137186|sp|O35779.2|BHE41_RAT",1495,0,"RecName: Full=Class E basic helix-loop-helix protein 41; Short=bHLHe41; AltName: Full=Class B basic helix-loop-helix protein 3; Short=bHLHb3; AltName: Full=Enhancer-of-split and hairy-related protein 1; Short=SHARP-1","gi|2267586|gb|AF009329.1|AF009329",2949,0,"Rattus norvegicus enhancer-of-split and hairy-related protein 1 (SHARP-1) mRNA, complete cds","O35779",580,0,"Class E basic helix-loop-helix protein 41",".",".",".",".","pfam00010","HLH","Helix-loop-helix DNA-binding domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007399|nervous system development;GO:0007623|circadian rhythm;GO:0009952|anterior/posterior pattern specification;GO:0010832|negative regulation of myotube differentiation;GO:0010944|negative regulation of transcription by competitive promoter binding;GO:0032922|circadian regulation of gene expression;GO:0045892|negative regulation of transcription, DNA-templated;GO:0048168|regulation of neuronal synaptic plasticity;GO:0050767|regulation of neurogenesis;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0042803|protein homodimerization activity;GO:0042826|histone deacetylase binding;GO:0043425|bHLH transcription factor binding;GO:0043426|MRF binding;GO:0046982|protein heterodimerization activity;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;GO:0070888|E-box binding;GO:1990837|sequence-specific double-stranded DNA binding;","K03730","BHLHB3, DEC2; class B basic helix-loop-helix protein 3"]
["ENSRNOG00000016783",415,26.69713185,206,13.29974309,2.007341921,1.00528638,{"v":3.59937E-17,"d":"3.60E-17"},{"v":5.28325E-17,"d":"5.28E-17"},"up","yes","Fshr","protein_coding","chr6:5198825-5406785:+","gi|40385885|ref|NP_954707.1|",3396,0,"follicle-stimulating hormone receptor precursor [Rattus norvegicus]","gi|40385884|ref|NM_199237.1|",2303,0,"Rattus norvegicus follicle stimulating hormone receptor (Fshr), mRNA","P20395",1311,0,"Follicle-stimulating hormone receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001541|ovarian follicle development;GO:0001545|primary ovarian follicle growth;GO:0001932|regulation of protein phosphorylation;GO:0003073|regulation of systemic arterial blood pressure;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007188|adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007190|activation of adenylate cyclase activity;GO:0007193|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007283|spermatogenesis;GO:0007286|spermatid development;GO:0007626|locomotory behavior;GO:0008584|male gonad development;GO:0009755|hormone-mediated signaling pathway;GO:0009992|cellular water homeostasis;GO:0010640|regulation of platelet-derived growth factor receptor signaling pathway;GO:0010738|regulation of protein kinase A signaling;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0022602|ovulation cycle process;GO:0031175|neuron projection development;GO:0032350|regulation of hormone metabolic process;GO:0033044|regulation of chromosome organization;GO:0033146|regulation of intracellular estrogen receptor signaling pathway;GO:0033148|positive regulation of intracellular estrogen receptor signaling pathway;GO:0035092|sperm chromatin condensation;GO:0035093|spermatogenesis, exchange of chromosomal proteins;GO:0042699|follicle-stimulating hormone signaling pathway;GO:0043408|regulation of MAPK cascade;GO:0045056|transcytosis;GO:0045670|regulation of osteoclast differentiation;GO:0045779|negative regulation of bone resorption;GO:0060009|Sertoli cell development;GO:0060011|Sertoli cell proliferation;GO:0060065|uterus development;GO:0060408|regulation of acetylcholine metabolic process;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0071711|basement membrane organization;","GO:0005768|endosome;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0043235|receptor complex;","GO:0004930|G protein-coupled receptor activity;GO:0004963|follicle-stimulating hormone receptor activity;GO:0005515|protein binding;GO:0008528|G protein-coupled peptide receptor activity;GO:0017046|peptide hormone binding;","K04247","FSHR; follicle stimulating hormone receptor"]
["ENSRNOG00000059997",146,9.392243975,36,2.324226948,4.041018449,2.014718938,{"v":4.17238e-17,"d":"4.17E-17"},{"v":6.10081e-17,"d":"6.10E-17"},"up","yes","Brip1","protein_coding","chr10:70907371-71030324:-","gi|109488700|ref|XP_340870.3|",6064,0,"PREDICTED: Fanconi anemia group J protein [Rattus norvegicus]","gi|672025061|ref|XM_001081096.4|",3797,0,"PREDICTED: Rattus norvegicus BRCA1 interacting protein C-terminal helicase 1 (Brip1), transcript variant X1, mRNA","Q5SXJ3",2058,0,"Fanconi anemia group J protein homolog","ECU02g1090",335,{"v":4e-99,"d":"4.00E-99"},"COG1199","pfam06733","DEAD_2","DEAD_2. This represents a conserved region within a number of RAD3-like DNA-binding helicases that are seemingly ubiquitous - members include proteins of eukaryotic, bacterial and archaeal origin. RAD3 is involved in nucleotide excision repair, and forms part of the transcription factor TFIIH in yeast.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0007129|synapsis;GO:0007283|spermatogenesis;GO:0007284|spermatogonial cell division;GO:0007286|spermatid development;GO:0008285|negative regulation of cell proliferation;GO:0008584|male gonad development;GO:0009636|response to toxic substance;GO:0010629|negative regulation of gene expression;GO:0010705|meiotic DNA double-strand break processing involved in reciprocal meiotic recombination;GO:0032508|DNA duplex unwinding;GO:0051026|chiasma assembly;GO:0071295|cellular response to vitamin;GO:0071456|cellular response to hypoxia;GO:0072520|seminiferous tubule development;GO:1904385|cellular response to angiotensin;GO:1990918|double-strand break repair involved in meiotic recombination;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0031965|nuclear membrane;","GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0005524|ATP binding;GO:0016818|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;GO:0043139|5'-3' DNA helicase activity;","K15362","BRIP1, BACH1, FANCJ; fanconi anemia group J protein [EC:5.6.2.3]"]
["ENSRNOG00000050630",255,16.40426174,99,6.391624106,2.566524793,1.359816197,{"v":4.42247e-17,"d":"4.42E-17"},{"v":6.46318e-17,"d":"6.46E-17"},"up","yes","AABR07070043.1","protein_coding","chr8:41698712-41717583:+","gi|8393418|ref|NP_058704.1|",1734,0,"glyceraldehyde-3-phosphate dehydrogenase [Rattus norvegicus]","gi|402691727|ref|NM_017008.4|",1197,0,"Rattus norvegicus glyceraldehyde-3-phosphate dehydrogenase (Gapdh), mRNA","P04797",672,0,"Glyceraldehyde-3-phosphate dehydrogenase","SPBC354.12",494,{"v":1E-172,"d":"1.00E-172"},"COG0057","pfam02800","Gp_dh_C","Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain. GAPDH is a tetrameric NAD-binding enzyme involved in glycolysis and glyconeogenesis. C-terminal domain is a mixed alpha/antiparallel beta fold.",".",".",".",".","."]
["ENSRNOG00000021272",157,10.0998788,42,2.711598106,3.724696066,1.897122707,{"v":5.33581e-17,"d":"5.34E-17"},{"v":7.74841e-17,"d":"7.75E-17"},"up","yes","Mcm8","protein_coding","chr3:120086763-120117008:+","gi|157816943|ref|NP_001099984.1|",4312,0,"DNA helicase MCM8 [Rattus norvegicus]","gi|157816942|ref|NM_001106514.1|",3226,0,"Rattus norvegicus minichromosome maintenance 8 homologous recombination repair factor (Mcm8), mRNA","D3ZVK1",1668,0,"DNA helicase MCM8","SSO0774",335,{"v":5e-100,"d":"5.00E-100"},"COG1241","pfam00493","MCM","MCM2/3/5 family.","GO:0000724|double-strand break repair via homologous recombination;GO:0006974|cellular response to DNA damage stimulus;GO:0007292|female gamete generation;GO:0032508|DNA duplex unwinding;GO:0036298|recombinational interstrand cross-link repair;GO:0048232|male gamete generation;GO:0050821|protein stabilization;GO:0071168|protein localization to chromatin;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005694|chromosome;GO:0005829|cytosol;GO:0042555|MCM complex;GO:0097362|MCM8-MCM9 complex;","GO:0003682|chromatin binding;GO:0003697|single-stranded DNA binding;GO:0005524|ATP binding;GO:0017116|single-stranded DNA-dependent ATP-dependent DNA helicase activity;GO:0019899|enzyme binding;GO:0032406|MutLbeta complex binding;GO:0032407|MutSalpha complex binding;GO:0032408|MutSbeta complex binding;","K10737","MCM8; DNA helicase MCM8 [EC:5.6.2.4]"]
["ENSRNOG00000007041",151,9.713896166,39,2.517912527,3.857916454,1.947821901,{"v":6.10492e-17,"d":"6.10E-17"},{"v":8.85176e-17,"d":"8.85E-17"},"up","yes","Abcg2","protein_coding","chr4:87745319-87802409:+","gi|564347060|ref|XP_006236634.1|",3394,0,"PREDICTED: ATP-binding cassette sub-family G member 2 isoform X1 [Rattus norvegicus]","gi|31341306|ref|NM_181381.2|",2169,0,"Rattus norvegicus ATP-binding cassette, subfamily G (WHITE), member 2 (Abcg2), mRNA","Q80W57",1311,0,"ATP-binding cassette sub-family G member 2","YCR011c_2",209,{"v":2e-60,"d":"2.00E-60"},"COG1131","pfam01061","ABC2_membrane","ABC-2 type transporter.","GO:0007568|aging;GO:0010039|response to iron ion;GO:0015711|organic anion transport;GO:0015747|urate transport;GO:0015878|biotin transport;GO:0019389|glucuronoside metabolic process;GO:0032218|riboflavin transport;GO:0032496|response to lipopolysaccharide;GO:0032868|response to insulin;GO:0043278|response to morphine;GO:0046415|urate metabolic process;GO:0051593|response to folic acid;GO:0055085|transmembrane transport;GO:0060136|embryonic process involved in female pregnancy;GO:0065003|protein-containing complex assembly;GO:0070633|transepithelial transport;GO:0071392|cellular response to estradiol stimulus;GO:0071549|cellular response to dexamethasone stimulus;GO:0097744|urate salt excretion;GO:0140115|export across plasma membrane;GO:1904479|negative regulation of intestinal absorption;GO:1904612|response to 2,3,7,8-tetrachlorodibenzodioxine;GO:1990748|cellular detoxification;GO:1990961|drug transmembrane export;GO:1990962|drug transport across blood-brain barrier;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0031526|brush border membrane;GO:0031966|mitochondrial membrane;GO:0045121|membrane raft;GO:0098591|external side of apical plasma membrane;","GO:0005524|ATP binding;GO:0008092|cytoskeletal protein binding;GO:0008514|organic anion transmembrane transporter activity;GO:0008559|xenobiotic transmembrane transporting ATPase activity;GO:0015143|urate transmembrane transporter activity;GO:0015225|biotin transmembrane transporter activity;GO:0015562|efflux transmembrane transporter activity;GO:0032217|riboflavin transmembrane transporter activity;GO:0042626|ATPase activity, coupled to transmembrane movement of substances;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0042887|amide transmembrane transporter activity;GO:0042910|xenobiotic transmembrane transporter activity;","K05681","ABCG2, CD338; ATP-binding cassette, subfamily G (WHITE), member 2"]
["ENSRNOG00000031662",74,4.760452426,5,0.322809298,14.74694952,3.882344651,{"v":7.08759e-17,"d":"7.09E-17"},{"v":1.02428E-16,"d":"1.02E-16"},"up","yes","Slc6a5","protein_coding","chr1:99645389-99697010:+","gi|978128196|sp|P58295.2|SC6A5_RAT",4048,0,"RecName: Full=Sodium- and chloride-dependent glycine transporter 2; Short=GlyT-2; Short=GlyT2; AltName: Full=Solute carrier family 6 member 5","gi|42627862|ref|NM_203334.1|",7029,0,"Rattus norvegicus solute carrier family 6 (neurotransmitter transporter), member 5 (Slc6a5), mRNA","P58295",1565,0,"Sodium- and chloride-dependent glycine transporter 2","BH3439",212,{"v":4e-57,"d":"4.00E-57"},"COG0733","pfam00209","SNF","Sodium:neurotransmitter symporter family.","GO:0001504|neurotransmitter uptake;GO:0015816|glycine transport;GO:0035725|sodium ion transmembrane transport;GO:0060012|synaptic transmission, glycinergic;GO:0098810|neurotransmitter reuptake;GO:1903804|glycine import across plasma membrane;","GO:0005768|endosome;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0031045|dense core granule;GO:0098690|glycinergic synapse;GO:0099056|integral component of presynaptic membrane;","GO:0015187|glycine transmembrane transporter activity;GO:0015375|glycine:sodium symporter activity;GO:0046872|metal ion binding;","K05038","SLC6A5_9, GLYT; solute carrier family 6 (neurotransmitter transporter, glycine) member 5/9"]
["ENSRNOG00000018310",180,11.57947887,55,3.550902281,3.260996208,1.705312763,{"v":7.60108e-17,"d":"7.60E-17"},{"v":1.09599E-16,"d":"1.10E-16"},"up","yes","Eno4","protein_coding","chr1:258096432-258128984:+","gi|564334485|ref|XP_006231731.1|",2849,0,"PREDICTED: enolase-like protein ENO4 isoform X1 [Rattus norvegicus]","gi|672040743|ref|XM_006231669.2|",3145,0,"PREDICTED: Rattus norvegicus enolase family member 4 (Eno4), transcript variant X1, mRNA","Q8C042",988,0,"Enolase 4","FN1764",100,{"v":2e-21,"d":"2.00E-21"},"COG0148","pfam00113","Enolase_C","Enolase, C-terminal TIM barrel domain.","GO:0006096|glycolytic process;GO:0008150|biological_process;GO:0030317|flagellated sperm motility;GO:0044782|cilium organization;","GO:0000015|phosphopyruvate hydratase complex;GO:0005575|cellular_component;GO:0097228|sperm principal piece;","GO:0000287|magnesium ion binding;GO:0003674|molecular_function;GO:0004634|phosphopyruvate hydratase activity;","K01689","ENO, eno; enolase [EC:4.2.1.11]"]
["ENSRNOG00000025781",167,10.74318318,48,3.098969263,3.466695622,1.793561172,{"v":8.94778e-17,"d":"8.95E-17"},{"v":1.28659e-16,"d":"1.29E-16"},"up","yes","Sec31b","protein_coding","chr1:243378456-243404557:-","gi|564333979|ref|XP_006231546.1|",5520,0,"PREDICTED: protein transport protein Sec31B isoform X1 [Rattus norvegicus]","gi|672040430|ref|XM_006231484.2|",4103,0,"PREDICTED: Rattus norvegicus SEC31 homolog B (S. cerevisiae) (Sec31b), transcript variant X1, mRNA","Q3TZ89",1857,0,"Protein transport protein Sec31B",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.","GO:0006886|intracellular protein transport;GO:0007029|endoplasmic reticulum organization;GO:0090110|cargo loading into COPII-coated vesicle;","GO:0005789|endoplasmic reticulum membrane;GO:0030120|vesicle coat;GO:0030127|COPII vesicle coat;GO:0070971|endoplasmic reticulum exit site;","GO:0005198|structural molecule activity;","K14005","SEC31; protein transport protein SEC31"]
["ENSRNOG00000011892",73,4.696121987,5,0.322809298,14.54766642,3.862715845,{"v":1.2827e-16,"d":"1.28E-16"},{"v":1.83782e-16,"d":"1.84E-16"},"up","yes","Slc36a2","protein_coding","chr10:39278046-39306082:-","gi|149052650|gb|EDM04467.1|",2381,0,"rCG34384 [Rattus norvegicus]","gi|183985819|gb|BC166414.1|",2285,0,"Rattus norvegicus solute carrier family 36 (proton/amino acid symporter), member 2, mRNA (cDNA clone MGC:187323 IMAGE:9027758), complete cds","Q8K415",894,0,"Proton-coupled amino acid transporter 2","YNL101w",132,{"v":5e-31,"d":"5.00E-31"},"COG0814","pfam01490","Aa_trans","Transmembrane amino acid transporter protein. This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.","GO:0003333|amino acid transmembrane transport;GO:0010155|regulation of proton transport;GO:0015808|L-alanine transport;GO:0015816|glycine transport;GO:0015824|proline transport;GO:0032973|amino acid export across plasma membrane;GO:0035524|proline transmembrane transport;GO:0070881|regulation of proline transport;GO:1900925|positive regulation of glycine import across plasma membrane;GO:1902600|proton transmembrane transport;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0005280|amino acid:proton symporter activity;GO:0015171|amino acid transmembrane transporter activity;GO:0015180|L-alanine transmembrane transporter activity;GO:0015187|glycine transmembrane transporter activity;GO:0015193|L-proline transmembrane transporter activity;","K14209","SLC36A, PAT; solute carrier family 36 (proton-coupled amino acid transporter)"]
["ENSRNOG00000012030",243,15.63229648,94,6.068814808,2.57584009,1.365043033,{"v":1.94978e-16,"d":"1.95E-16"},{"v":2.77355E-16,"d":"2.77E-16"},"up","yes","Wwox","protein_coding","chr19:42432152-43359391:+","gi|672084805|ref|XP_008770713.1|",1811,0,"PREDICTED: WW domain-containing oxidoreductase isoform X2 [Rattus norvegicus]","gi|672084804|ref|XM_008772491.1|",1130,0,"PREDICTED: Rattus norvegicus WW domain-containing oxidoreductase (Wwox), transcript variant X2, mRNA","Q91WL8",686,0,"WW domain-containing oxidoreductase","VNG0479G",148,{"v":9e-38,"d":"9.00E-38"},"COG1028","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.",".",".",".",".","."]
["ENSRNOG00000019177",95,6.111391628,14,0.903866035,6.761390947,2.757320067,{"v":3.31331e-16,"d":"3.31E-16"},{"v":4.67936E-16,"d":"4.68E-16"},"up","yes","Psd2","protein_coding","chr18:27565587-27616672:+","gi|564393056|ref|XP_006254639.1|",3334,0,"PREDICTED: PH and SEC7 domain-containing protein 2 isoform X1 [Rattus norvegicus]","gi|672083033|ref|XM_006254577.2|",4392,0,"PREDICTED: Rattus norvegicus pleckstrin and Sec7 domain containing 2 (Psd2), transcript variant X1, mRNA","Q6P1I6",1170,0,"PH and SEC7 domain-containing protein 2","YDR170c",95.1,{"v":1e-18,"d":"1.00E-18"},"COG5307","pfam01369","Sec7","Sec7 domain. The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.","GO:0032012|regulation of ARF protein signal transduction;GO:0050790|regulation of catalytic activity;","GO:0030425|dendrite;GO:0032154|cleavage furrow;GO:0032587|ruffle membrane;GO:0043025|neuronal cell body;GO:0098794|postsynapse;GO:0098978|glutamatergic synapse;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0005543|phospholipid binding;","K12494","PSD; PH and SEC7 domain-containing protein"]
["ENSRNOG00000019100",372,23.930923,182,11.75025846,2.0366295,1.026183552,{"v":4.9297E-16,"d":"4.93E-16"},{"v":6.92621e-16,"d":"6.93E-16"},"up","yes","Kif2c","protein_coding","chr5:130637347-130662637:-","gi|564352294|ref|XP_006238695.1|",3441,0,"PREDICTED: kinesin-like protein KIF2C isoform X2 [Rattus norvegicus]","gi|564352293|ref|XM_006238633.1|",2580,0,"PREDICTED: Rattus norvegicus kinesin family member 2C (Kif2c), transcript variant X2, mRNA","Q62909",1317,0,"Kinesin-like protein KIF2C","ECU11g0470",234,{"v":1e-65,"d":"1.00E-65"},"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0007018|microtubule-based movement;GO:0007019|microtubule depolymerization;GO:0007080|mitotic metaphase plate congression;GO:0030951|establishment or maintenance of microtubule cytoskeleton polarity;GO:0051301|cell division;GO:0051310|metaphase plate congression;GO:0051315|attachment of mitotic spindle microtubules to kinetochore;GO:0051983|regulation of chromosome segregation;","GO:0000775|chromosome, centromeric region;GO:0000776|kinetochore;GO:0005634|nucleus;GO:0005813|centrosome;GO:0005819|spindle;GO:0005871|kinesin complex;GO:0005874|microtubule;GO:0005881|cytoplasmic microtubule;GO:0015630|microtubule cytoskeleton;GO:0035371|microtubule plus-end;","GO:0003777|microtubule motor activity;GO:0005524|ATP binding;GO:0008017|microtubule binding;GO:0016887|ATPase activity;GO:0051010|microtubule plus-end binding;","K10393","KIF2_24, MCAK; kinesin family member 2/24"]
["ENSRNOG00000010736",108,6.947687324,20,1.291237193,5.380643743,2.427778788,{"v":4.97468e-16,"d":"4.97E-16"},{"v":6.98597E-16,"d":"6.99E-16"},"up","yes","Pbx4","protein_coding","chr16:19555090-19590014:-","gi|157822083|ref|NP_001101869.1|",1821,0,"pre-B-cell leukemia transcription factor 4 [Rattus norvegicus]","gi|157822082|ref|NM_001108399.1|",1384,0,"Rattus norvegicus pre-B-cell leukemia homeobox 4 (Pbx4), mRNA","Q99NE9",632,0,"Pre-B-cell leukemia transcription factor 4",".",".",".",".","pfam03792","PBC","PBC domain. The PBC domain is a member of the TALE (three-amino-acid loop extension) superclass of homeodomain proteins.","GO:0001654|eye development;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007420|brain development;GO:0009887|animal organ morphogenesis;GO:0048568|embryonic organ development;GO:0048666|neuron development;","GO:0001741|XY body;GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565|sequence-specific DNA binding;","K15611","PBX4; pre-B-cell leukemia transcription factor 4"]
["ENSRNOG00000012486",294,18.91314883,129,8.328479896,2.27090046,1.18326447,{"v":5.80342e-16,"d":"5.80E-16"},{"v":8.12978e-16,"d":"8.13E-16"},"up","yes","Prim2","protein_coding","chr9:35692376-35903030:-","gi|564367798|ref|XP_006244748.1|",2584,0,"PREDICTED: DNA primase large subunit isoform X1 [Rattus norvegicus]","gi|672064681|ref|XM_006244686.2|",2003,0,"PREDICTED: Rattus norvegicus primase, DNA, polypeptide 2 (Prim2), transcript variant X1, mRNA","O89044",999,0,"DNA primase large subunit","SPBC17D11.06",303,{"v":4e-94,"d":"4.00E-94"},"COG2219","pfam04104","DNA_primase_lrg","Eukaryotic and archaeal DNA primase, large subunit. DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. DNA primase is a heterodimer of two subunits, the small subunit Pri1 (48 kDa in yeast), and the large subunit Pri2 (58 kDa in the yeast S. cerevisiae). The large subunit of DNA primase forms interactions with the small subunit and the structure implicates that it is not directly involved in catalysis, but plays roles in correctly positioning the primase/DNA complex, and in the transfer of RNA to DNA polymerase.","GO:0006260|DNA replication;GO:0006269|DNA replication, synthesis of RNA primer;GO:1903934|positive regulation of DNA primase activity;","GO:0005575|cellular_component;GO:0005658|alpha DNA polymerase:primase complex;","GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0046872|metal ion binding;GO:0051539|4 iron, 4 sulfur cluster binding;GO:0071667|DNA/RNA hybrid binding;","K02685","PRI2; DNA primase large subunit"]
["ENSRNOG00000025587",326,20.97172285,151,9.748840808,2.151201693,1.105142796,{"v":7.12955e-16,"d":"7.13E-16"},{"v":9.95333E-16,"d":"9.95E-16"},"up","yes","Plagl1","protein_coding","chr1:7477177-7517228:+","gi|6981166|ref|NP_036892.1|",2080,0,"zinc finger protein PLAGL1 [Rattus norvegicus]","gi|158819032|ref|NM_012760.3|",2453,0,"Rattus norvegicus PLAG1 like zinc finger 1 (Plagl1), mRNA","Q9UM63",578,0,"Zinc finger protein PLAGL1","ECU03g0790",72,{"v":1e-12,"d":"1.00E-12"},"COG5048","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0006355|regulation of transcription, DNA-templated;GO:0010468|regulation of gene expression;GO:0035914|skeletal muscle cell differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005794|Golgi apparatus;GO:0016604|nuclear body;GO:0043231|intracellular membrane-bounded organelle;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;","K19485","PLAGL1; zinc finger protein PLAGL1"]
["ENSRNOG00000052725",91,5.854069875,13,0.839304176,6.974908556,2.802174303,{"v":7.96346e-16,"d":"7.96E-16"},{"v":1.11012E-15,"d":"1.11E-15"},"up","yes","Shisal1","protein_coding","chr7:115509035-115575449:-","gi|568993424|ref|XP_006521503.1|",876,{"v":1e-104,"d":"1.00E-104"},"PREDICTED: uncharacterized protein KIAA1644 isoform X2 [Mus musculus]","gi|672060434|ref|XR_593666.1|",3776,0,"PREDICTED: Rattus norvegicus similar to mKIAA1644 protein (RGD1566029), transcript variant X12, misc_RNA","Q0VBP7",320,{"v":2e-98,"d":"2.00E-98"},"Protein shisa-like-1",".",".",".",".","pfam13908","Shisa","Wnt and FGF inhibitory regulator. Shisa is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000064025",100,6.433043818,17,1.097551614,5.861267694,2.551212729,{"v":9.81396e-16,"d":"9.81E-16"},{"v":1.36205e-15,"d":"1.36E-15"},"up","yes","ENSRNOG00000064025","protein_coding","chr17:41574520-41575555:-","gi|586484892|ref|XP_006872940.1|",420,{"v":2e-47,"d":"2.00E-47"},"PREDICTED: histone H4-like [Chrysochloris asiatica]","gi|672030058|ref|XM_003752983.3|",466,0,"PREDICTED: Rattus norvegicus similar to germinal histone H4 gene (LOC680097), mRNA","Q28DR4",162,{"v":9e-48,"d":"9.00E-48"},"Histone H4",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.",".",".",".",".","."]
["ENSRNOG00000022391",102,6.561704695,18,1.162113474,5.646354545,2.497319721,{"v":1.12642e-15,"d":"1.13E-15"},{"v":1.56035E-15,"d":"1.56E-15"},"up","yes","ENSRNOG00000022391","protein_coding","chrX:77646558-77678045:+","gi|293351051|ref|XP_002727665.1|",4092,0,"PREDICTED: zinc finger protein 711 [Rattus norvegicus]","gi|672088039|ref|XM_002730265.4|",2528,0,"PREDICTED: Rattus norvegicus zinc finger protein 711 (Zfp711), transcript variant X3, mRNA","A2ANX9",1459,0,"Zinc finger protein 711","SPAC144.09c",85.5,{"v":6e-17,"d":"6.00E-17"},"COG5048","pfam04704","Zfx_Zfy_act","Zfx / Zfy transcription activation region. Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0045893|positive regulation of transcription, DNA-templated;","GO:0005634|nucleus;GO:0005694|chromosome;","GO:0043035|chromatin insulator sequence binding;GO:0043565|sequence-specific DNA binding;GO:0046872|metal ion binding;","K24376","ZNF711; zinc finger protein 711"]
["ENSRNOG00000023664",242,15.56796604,97,6.262500387,2.485902608,1.313769776,{"v":1.58188E-15,"d":"1.58E-15"},{"v":2.17806e-15,"d":"2.18E-15"},"up","yes","Lepr","protein_coding","chr5:116289823-116475908:+","gi|149044573|gb|EDL97832.1|",6168,0,"rCG53475, isoform CRA_b [Rattus norvegicus]","gi|6981149|ref|NM_012596.1|",3611,0,"Rattus norvegicus leptin receptor (Lepr), mRNA","Q62959",2375,0,"Leptin receptor",".",".",".",".","pfam06328","Lep_receptor_Ig","Ig-like C2-type domain. This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.","GO:0001525|angiogenesis;GO:0001542|ovulation from ovarian follicle;GO:0001666|response to hypoxia;GO:0001934|positive regulation of protein phosphorylation;GO:0005977|glycogen metabolic process;GO:0006091|generation of precursor metabolites and energy;GO:0006909|phagocytosis;GO:0007565|female pregnancy;GO:0007568|aging;GO:0007584|response to nutrient;GO:0008203|cholesterol metabolic process;GO:0008584|male gonad development;GO:0010507|negative regulation of autophagy;GO:0014009|glial cell proliferation;GO:0019221|cytokine-mediated signaling pathway;GO:0019953|sexual reproduction;GO:0030217|T cell differentiation;GO:0033210|leptin-mediated signaling pathway;GO:0033993|response to lipid;GO:0035094|response to nicotine;GO:0035774|positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0042060|wound healing;GO:0042593|glucose homeostasis;GO:0042755|eating behavior;GO:0043410|positive regulation of MAPK cascade;GO:0043627|response to estrogen;GO:0044321|response to leptin;GO:0045721|negative regulation of gluconeogenesis;GO:0046850|regulation of bone remodeling;GO:0051049|regulation of transport;GO:0051346|negative regulation of hydrolase activity;GO:0060259|regulation of feeding behavior;GO:0071310|cellular response to organic substance;GO:0071548|response to dexamethasone;GO:0097009|energy homeostasis;GO:0098868|bone growth;GO:0120162|positive regulation of cold-induced thermogenesis;GO:1903999|negative regulation of eating behavior;GO:1904060|negative regulation of locomotor rhythm;","GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016328|lateral plasma membrane;GO:0043235|receptor complex;","GO:0004896|cytokine receptor activity;GO:0016500|protein-hormone receptor activity;GO:0017046|peptide hormone binding;GO:0019955|cytokine binding;GO:0038021|leptin receptor activity;GO:0042802|identical protein binding;","K05062","LEPR, CD295; leptin receptor"]
["ENSRNOG00000027837",136,8.748939593,35,2.259665088,3.871785974,1.952999205,{"v":1.85181E-15,"d":"1.85E-15"},{"v":2.54481E-15,"d":"2.54E-15"},"up","yes","ENSRNOG00000027837","protein_coding","chrX:115675427-115725925:-","gi|149059998|gb|EDM10814.1|",2618,0,"similar to novel protein (predicted), partial [Rattus norvegicus]","gi|755490487|ref|XM_006544556.2|",1435,0,"PREDICTED: Mus musculus predicted gene 14569 (Gm14569), transcript variant X3, mRNA","E9Q0C6",484,{"v":3e-140,"d":"3.00E-140"},"Acrosomal protein KIAA1210",".",".",".",".","pfam15262","DUF4592","Domain of unknown function (DUF4592). This protein family is a domain of unknown function, which lies to the N-terminus of the protein. This domain family is found in eukaryotes, and is typically between 114 and 130 amino acids in length. There are two completely conserved residues (L and A) that may be functionally important. In humans, the gene that encodes this protein lies in the position, chromosome 2 open reading frame 55.",".","GO:0001669|acrosomal vesicle;GO:0061832|basal ectoplasmic specialization;",".",".","."]
["ENSRNOG00000062817",119,7.655322144,27,1.743170211,4.391609091,2.134749642,{"v":3.34102E-15,"d":"3.34E-15"},{"v":4.53891e-15,"d":"4.54E-15"},"up","yes","ENSRNOG00000062817","protein_coding","chr9:113819937-113848167:+","gi|672070372|ref|XP_008766741.1|",444,{"v":1E-51,"d":"1.00E-51"},"PREDICTED: zinc finger protein 431-like isoform X2, partial [Rattus norvegicus]","gi|672070371|ref|XM_008768519.1|",323,{"v":3e-167,"d":"3.00E-167"},"PREDICTED: Rattus norvegicus zinc finger protein 120-like (LOC102547688), transcript variant X2, partial mRNA","E9QAG8",118,{"v":2e-30,"d":"2.00E-30"},"Zinc finger protein 431",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000065497",271,17.43354875,118,7.618299439,2.288377989,1.194325373,{"v":4.95835e-15,"d":"4.96E-15"},{"v":6.69631e-15,"d":"6.70E-15"},"up","yes","ENSRNOG00000065497","lncRNA","chr1:111056725-111100648:-",".",".",".",".","gi|672013721|ref|XR_598849.1|",1096,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102547183 (LOC102547183), ncRNA",".",".",".",".",".",".",".",".","pfam14897","EpsG","EpsG family. This family of proteins are related to the EpsG protein from B. subtilis. These proteins are likely glycosyl transferases belonging to the membrane protein GT-C clan.",".",".",".",".","."]
["ENSRNOG00000047848",61,3.924156729,3,0.193685579,20.26044866,4.340594217,{"v":5.08485e-15,"d":"5.08E-15"},{"v":6.86228E-15,"d":"6.86E-15"},"up","yes","Cbr1","pseudogene","chr11:32908950-32911393:+","gi|564376239|ref|XP_006248171.1|",1585,0,"PREDICTED: carbonyl reductase [NADPH] 1 [Rattus norvegicus]","gi|672070752|ref|XM_006248109.2|",1023,0,"PREDICTED: Rattus norvegicus carbonyl reductase [NADPH] 1-like (LOC102556347), mRNA","P47727",524,0,"Carbonyl reductase [NADPH] 1","all0352",126,{"v":6e-33,"d":"6.00E-33"},"COG1028","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.","GO:0001542|ovulation from ovarian follicle;GO:0006706|steroid catabolic process;GO:0006805|xenobiotic metabolic process;GO:0030855|epithelial cell differentiation;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0032570|response to progesterone;GO:0033574|response to testosterone;GO:0034698|response to gonadotropin;GO:0042373|vitamin K metabolic process;GO:0042376|phylloquinone catabolic process;GO:1905344|prostaglandin catabolic process;GO:2000379|positive regulation of reactive oxygen species metabolic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005902|microvillus;GO:0035003|subapical complex;GO:0043231|intracellular membrane-bounded organelle;","GO:0004090|carbonyl reductase (NADPH) activity;GO:0005515|protein binding;GO:0016491|oxidoreductase activity;GO:0016655|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0047020|15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity;GO:0047021|15-hydroxyprostaglandin dehydrogenase (NADP+) activity;GO:0050221|prostaglandin-E2 9-reductase activity;","K00079","CBR1; carbonyl reductase 1 [EC:1.1.1.184 1.1.1.189 1.1.1.197]"]
["ENSRNOG00000022609",321,20.65007066,152,9.813402668,2.104272224,1.073321354,5.34E-15,{"v":7.19812e-15,"d":"7.20E-15"},"up","yes","Mrps10","protein_coding","chr9:13614897-13624779:-","gi|564367172|ref|XP_006244526.1|",944,{"v":1e-122,"d":"1.00E-122"},"PREDICTED: 28S ribosomal protein S10, mitochondrial isoform X1 [Rattus norvegicus]","gi|672064361|ref|XM_006244464.2|",617,0,"PREDICTED: Rattus norvegicus mitochondrial ribosomal protein S10 (Mrps10), transcript variant X1, mRNA","P82664",302,{"v":3E-98,"d":"3.00E-98"},"28S ribosomal protein S10, mitochondrial","SMc01310",55.5,2E-8,"COG0051","pfam00338","Ribosomal_S10","Ribosomal protein S10p/S20e. This family includes small ribosomal subunit S10 from prokaryotes and S20 from eukaryotes.",".","GO:0005739|mitochondrion;GO:0005763|mitochondrial small ribosomal subunit;",".","K02946","RP-S10, MRPS10, rpsJ; small subunit ribosomal protein S10"]
["ENSRNOG00000011970",302,19.42779233,139,8.974098492,2.164873981,1.114283047,{"v":5.39078e-15,"d":"5.39E-15"},{"v":7.2597e-15,"d":"7.26E-15"},"up","yes","Tmem82","protein_coding","chr5:153927471-153936979:-","gi|845633169|ref|NP_001013958.2|",1544,0,"solute carrier family 25 member 34 [Rattus norvegicus]","gi|845633168|ref|NM_001013936.2|",2228,0,"Rattus norvegicus solute carrier family 25, member 34 (Slc25a34), mRNA","Q5XIF9",599,0,"Solute carrier family 25 member 34",".",".",".",".","pfam00153","Mito_carr","Mitochondrial carrier protein.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000055383",99,6.36871338,18,1.162113474,5.480285294,2.454250999,{"v":5.47411e-15,"d":"5.47E-15"},{"v":7.36845e-15,"d":"7.37E-15"},"up","yes","AABR07067762.1","protein_coding","chr9:56634648-56635789:+","gi|126723054|ref|NP_598282.2|",573,{"v":4e-72,"d":"4.00E-72"},"glycine cleavage system H protein, mitochondrial precursor [Rattus norvegicus]","gi|32362328|gb|AC103419.6|",350,0,"Rattus norvegicus 9 BAC CH230-145A24 (Children's Hospital Oakland Research Institute) complete sequence","Q5I0P2",225,{"v":1E-73,"d":"1.00E-73"},"Glycine cleavage system H protein, mitochondrial","TM0212",92.4,{"v":4e-23,"d":"4.00E-23"},"COG0509","pfam01597","GCV_H","Glycine cleavage H-protein. This is a family of glycine cleavage H-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyses the catabolism of glycine in eukaryotes. A lipoyl group is attached to a completely conserved lysine residue. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.",".",".",".",".","."]
["ENSRNOG00000065699",99,6.36871338,18,1.162113474,5.480285294,2.454250999,{"v":5.47411e-15,"d":"5.47E-15"},{"v":7.36845e-15,"d":"7.37E-15"},"up","yes","ENSRNOG00000065699","protein_coding","chr14:100606613-100607588:+","gi|913513001|ref|XP_013208915.1|",1103,{"v":4e-147,"d":"4.00E-147"},"PREDICTED: 60 kDa heat shock protein, mitochondrial [Microtus ochrogaster]","gi|302318920|ref|NG_023470.1|",638,0,"Rattus norvegicus heat shock protein 1, pseudogene 1 (Hspd1-ps1) on chromosome 14","P63039",430,{"v":2e-147,"d":"2.00E-147"},"60 kDa heat shock protein, mitochondrial","SPAC12G12.04",280,{"v":2e-89,"d":"2.00E-89"},"COG0459","pfam00118","Cpn60_TCP1","TCP-1/cpn60 chaperonin family. This family includes members from the HSP60 chaperone family and the TCP-1 (T-complex protein) family.",".",".",".",".","."]
["ENSRNOG00000016689",328,21.10038372,157,10.13621197,2.081683354,1.057750636,{"v":5.72727e-15,"d":"5.73E-15"},{"v":7.70196e-15,"d":"7.70E-15"},"up","yes","Fanci","protein_coding","chr1:133327297-133383640:+","gi|392337748|ref|XP_003753343.1|",6356,0,"PREDICTED: Fanconi anemia group I protein isoform X1 [Rattus norvegicus]","gi|672013877|ref|XM_003753295.3|",4383,0,"PREDICTED: Rattus norvegicus Fanconi anemia, complementation group I (Fanci), transcript variant X1, mRNA","Q8K368",2314,0,"Fanconi anemia group I protein homolog",".",".",".",".","pfam14678","FANCI_S4","FANCI solenoid 4. This is the solenoid 4 (S4) domain of the Fanconi anemia group I protein.","GO:0006281|DNA repair;GO:0008150|biological_process;GO:0031398|positive regulation of protein ubiquitination;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0003674|molecular_function;GO:0070182|DNA polymerase binding;","K10895","FANCI; fanconi anemia group I protein"]
["ENSRNOG00000070970",222,14.28135728,87,5.61688179,2.542577503,1.346291751,{"v":7.31391e-15,"d":"7.31E-15"},{"v":9.7758e-15,"d":"9.78E-15"},"up","yes","ENSRNOG00000070970","lncRNA","chr9:55359467-55361607:+",".",".",".",".","gi|672065137|ref|XM_006244912.2|",2141,0,"PREDICTED: Rattus norvegicus HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 (Hecw2), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.",".",".",".",".","."]
["ENSRNOG00000050848",262,16.8545748,113,7.295490141,2.310273125,1.20806342,{"v":8.04283e-15,"d":"8.04E-15"},{"v":1.07275e-14,"d":"1.07E-14"},"up","yes","Dtx1","protein_coding","chr12:35849617-35880838:+","gi|60360548|dbj|BAD90518.1|",2979,0,"mKIAA4160 protein [Mus musculus]","gi|672073190|ref|XM_006249412.2|",3596,0,"PREDICTED: Rattus norvegicus deltex 1, E3 ubiquitin ligase (Dtx1), transcript variant X1, mRNA","Q61010",1058,0,"E3 ubiquitin-protein ligase DTX1",".",".",".",".","pfam02825","WWE","WWE domain. The WWE domain is named after three of its conserved residues and is predicted to mediate specific protein- protein interactions in ubiquitin and ADP ribose conjugation systems.","GO:0007219|Notch signaling pathway;GO:0008593|regulation of Notch signaling pathway;GO:0010001|glial cell differentiation;GO:0016567|protein ubiquitination;GO:0045581|negative regulation of T cell differentiation;GO:0045665|negative regulation of neuron differentiation;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0016604|nuclear body;","GO:0005112|Notch binding;GO:0008270|zinc ion binding;GO:0031625|ubiquitin protein ligase binding;GO:0061630|ubiquitin protein ligase activity;","K06058","DTX; deltex [EC:2.3.2.27]"]
["ENSRNOG00000013971",179,11.51514844,61,3.938273439,2.923907802,1.54789782,{"v":8.81141e-15,"d":"8.81E-15"},{"v":1.17389E-14,"d":"1.17E-14"},"up","yes","Psat1","protein_coding","chr1:213196709-213218682:-","gi|61889115|ref|NP_942033.2|",1916,0,"phosphoserine aminotransferase [Rattus norvegicus]","gi|61889114|ref|NM_198738.2|",2050,0,"Rattus norvegicus phosphoserine aminotransferase 1 (Psat1), mRNA","Q99K85",726,0,"Phosphoserine aminotransferase","PA3167",360,{"v":1e-116,"d":"1.00E-116"},"COG1932","pfam00266","Aminotran_5","Aminotransferase class-V. This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.","GO:0006564|L-serine biosynthetic process;","GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004648|O-phospho-L-serine:2-oxoglutarate aminotransferase activity;GO:0030170|pyridoxal phosphate binding;GO:0042802|identical protein binding;","K00831","serC, PSAT1; phosphoserine aminotransferase [EC:2.6.1.52]"]
["ENSRNOG00000057162",121,7.78398302,29,1.87229393,4.157457809,2.055701623,{"v":8.85207e-15,"d":"8.85E-15"},{"v":1.17903e-14,"d":"1.18E-14"},"up","yes","RGD1564409","protein_coding","chr7:17311697-17330495:+","gi|392349284|ref|XP_234980.5|",2508,0,"PREDICTED: sperm motility kinase W-like [Rattus norvegicus]","gi|672058347|ref|XM_008765277.1|",4550,0,"PREDICTED: Rattus norvegicus similar to hypothetical protein 4930509O22 (RGD1566251), transcript variant X11, mRNA","Q8C0V7",562,{"v":1e-178,"d":"1.00E-178"},"Putative sperm motility kinase W",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.",".",".","GO:0005524|ATP binding;",".","."]
["ENSRNOG00000050482",341,21.93667942,168,10.84639242,2.022486239,1.016129887,{"v":1.30722E-14,"d":"1.31E-14"},{"v":1.72743e-14,"d":"1.73E-14"},"up","yes","Dbf4","protein_coding","chr4:25676634-25701066:+","gi|300795635|ref|NP_001178677.1|",3399,0,"protein DBF4 homolog A [Rattus norvegicus]","gi|300795634|ref|NM_001191748.1|",2239,0,"Rattus norvegicus DBF4 homolog (S. cerevisiae) (Dbf4), mRNA","Q9QZ41",1043,0,"Protein DBF4 homolog A",".",".",".",".","pfam07535","zf-DBF","DBF zinc finger. This domain is predicted to bind metal ions and is often found associated with pfam00533 and pfam02178. It was first identified in the Drosophila chiffon gene product, and is associated with initiation of DNA replication.","GO:0010571|positive regulation of nuclear cell cycle DNA replication;GO:0071902|positive regulation of protein serine/threonine kinase activity;GO:1901987|regulation of cell cycle phase transition;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0016604|nuclear body;GO:0031431|Dbf4-dependent protein kinase complex;","GO:0003676|nucleic acid binding;GO:0008270|zinc ion binding;GO:0043539|protein serine/threonine kinase activator activity;","K06629","ASK, DBF4; activator of S phase kinase"]
["ENSRNOG00000053638",116,7.462330829,27,1.743170211,4.280896257,2.097912874,{"v":1.44548e-14,"d":"1.45E-14"},{"v":1.90636e-14,"d":"1.91E-14"},"up","yes","Clec12b","protein_coding","chr4:162827462-162838946:-","gi|157819437|ref|NP_001102823.1|",1367,0,"C-type lectin domain family 12 member B [Rattus norvegicus]","gi|157819436|ref|NM_001109353.1|",1487,0,"Rattus norvegicus C-type lectin domain family 12, member B (Clec12b), mRNA","Q149M0",473,{"v":3e-164,"d":"3.00E-164"},"C-type lectin domain family 12 member B",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0002769|natural killer cell inhibitory signaling pathway;GO:0045953|negative regulation of natural killer cell mediated cytotoxicity;GO:2000272|negative regulation of signaling receptor activity;","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0032991|protein-containing complex;","GO:0019903|protein phosphatase binding;GO:0030246|carbohydrate binding;GO:0030547|receptor inhibitor activity;","K17517","CLEC12B; C-type lectin domain family 12 member B"]
["ENSRNOG00000033763",65,4.181478482,5,0.322809298,12.9534016,3.695259099,{"v":1.47126E-14,"d":"1.47E-14"},{"v":1.93881e-14,"d":"1.94E-14"},"up","yes","RGD1307537","protein_coding","chr17:29929780-29966579:-","gi|149045215|gb|EDL98301.1|",1064,{"v":8e-144,"d":"8.00E-144"},"similar to RIKEN cDNA 4933417A18 [Rattus norvegicus]","gi|50927387|gb|BC079269.1|",695,0,"Rattus norvegicus similar to RIKEN cDNA 4933417A18, mRNA (cDNA clone MGC:94380 IMAGE:7133712), complete cds","Q6AXY2",413,{"v":8e-145,"d":"8.00E-145"},"Uncharacterized protein C6orf201 homolog",".",".",".",".","pfam15023","DUF4523","Protein of unknown function (DUF4523). This family of proteins is functionally uncharacterized. This family of proteins is found in mammals.",".",".","GO:0003676|nucleic acid binding;",".","."]
["ENSRNOG00000040201",137,8.813270031,38,2.453350667,3.592340121,1.84492395,{"v":1.57883e-14,"d":"1.58E-14"},{"v":2.07673E-14,"d":"2.08E-14"},"up","yes","Atp6ap1l","protein_coding","chr2:22037563-22065038:-","gi|300797587|ref|NP_001178772.1|",1440,0,"V-type proton ATPase subunit S1-like protein precursor [Rattus norvegicus]","gi|300797586|ref|NM_001191843.1|",1132,0,"Rattus norvegicus ATPase H+ transporting accessory protein 1 like (Atp6ap1l), mRNA","Q52LC2",224,{"v":2e-69,"d":"2.00E-69"},"V-type proton ATPase subunit S1-like protein",".",".",".",".","pfam01299","Lamp","Lysosome-associated membrane glycoprotein (Lamp).","GO:0030641|regulation of cellular pH;GO:1902600|proton transmembrane transport;","GO:0016021|integral component of membrane;GO:0033180|proton-transporting V-type ATPase, V1 domain;GO:0033181|plasma membrane proton-transporting V-type ATPase complex;",".",".","."]
["ENSRNOG00000042152",207,13.3164007,79,5.100386913,2.610860888,1.38452559,{"v":1.66917e-14,"d":"1.67E-14"},{"v":2.19305e-14,"d":"2.19E-14"},"up","yes","Gipc2","protein_coding","chr2:241030770-241110236:-","gi|81295361|ref|NP_001032287.1|",1573,0,"PDZ domain-containing protein GIPC2 [Rattus norvegicus]","gi|81295360|ref|NM_001037210.1|",1253,0,"Rattus norvegicus GIPC PDZ domain containing family, member 2 (Gipc2), mRNA","Q498D9",585,0,"PDZ domain-containing protein GIPC2",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.",".","GO:0005737|cytoplasm;","GO:0042802|identical protein binding;","K20056","GIPC, SEMCAP; PDZ domain-containing protein GIPC"]
["ENSRNOG00000003068",133,8.555948279,36,2.324226948,3.681201738,1.880176815,{"v":1.77927e-14,"d":"1.78E-14"},{"v":2.33501e-14,"d":"2.34E-14"},"up","yes","Mrnip","protein_coding","chr10:34501384-34525469:+","gi|187937161|ref|NP_001102500.2|",1495,0,"UPF0544 protein C5orf45 homolog [Rattus norvegicus]","gi|672067353|ref|XM_008767694.1|",1009,0,"PREDICTED: Rattus norvegicus similar to RIKEN cDNA 3010026O09 (RGD1564036), transcript variant X1, mRNA","Q9D1F5",424,{"v":7e-145,"d":"7.00E-145"},"MRN complex-interacting protein",".",".",".",".","pfam04929","Herpes_DNAp_acc","Herpes DNA replication accessory factor. Replicative DNA polymerases are capable of polymerising tens of thousands of nucleotides without dissociating from their DNA templates. The high processivity of these polymerases is dependent upon accessory proteins that bind to the catalytic subunit of the polymerase or to the substrate. The Epstein-Barr virus (EBV) BMRF1 protein is an essential component of the viral DNA polymerase and is absolutely required for lytic virus replication. BMRF1 is also a transactivator. This family is predicted to have a UL42 like structure.","GO:0006974|cellular response to DNA damage stimulus;GO:0007095|mitotic G2 DNA damage checkpoint;GO:0008150|biological_process;GO:0010212|response to ionizing radiation;GO:0045860|positive regulation of protein kinase activity;GO:0071168|protein localization to chromatin;GO:1905168|positive regulation of double-strand break repair via homologous recombination;GO:2001032|regulation of double-strand break repair via nonhomologous end joining;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0030870|Mre11 complex;","GO:0003674|molecular_function;GO:0003682|chromatin binding;",".","."]
["ENSRNOG00000050553",180,11.57947887,63,4.067397158,2.846901451,1.509392553,{"v":2.27096e-14,"d":"2.27E-14"},{"v":2.96392e-14,"d":"2.96E-14"},"up","yes","Atp6v1c2","protein_coding","chr6:40080547-40120028:-","gi|354478153|ref|XP_003501280.1|",2230,0,"PREDICTED: V-type proton ATPase subunit C 2 isoform X1 [Cricetulus griseus]","gi|755541464|ref|XM_006515194.2|",1319,0,"PREDICTED: Mus musculus ATPase, H+ transporting, lysosomal V1 subunit C2 (Atp6v1c2), transcript variant X1, mRNA","Q6AYE4",830,0,"V-type proton ATPase subunit C 2","SPAPB2B4.05",192,{"v":3e-54,"d":"3.00E-54"},"COG5127","pfam03223","V-ATPase_C","V-ATPase subunit C.","GO:0030177|positive regulation of Wnt signaling pathway;GO:1902600|proton transmembrane transport;","GO:0000221|vacuolar proton-transporting V-type ATPase, V1 domain;GO:0033180|proton-transporting V-type ATPase, V1 domain;","GO:0015078|proton transmembrane transporter activity;GO:0042802|identical protein binding;GO:0046961|proton-transporting ATPase activity, rotational mechanism;","K02148","ATPeV1C, ATP6C; V-type H+-transporting ATPase subunit C"]
["ENSRNOG00000003831",248,15.95394867,106,6.843557123,2.331236283,1.221095236,{"v":2.52059E-14,"d":"2.52E-14"},{"v":3.28448e-14,"d":"3.28E-14"},"up","yes","Tdp1","protein_coding","chr6:119163166-119231021:+","gi|564356903|ref|XP_006240494.1|",3246,0,"PREDICTED: tyrosyl-DNA phosphodiesterase 1 isoform X1 [Rattus norvegicus]","gi|672056624|ref|XM_006240432.2|",2400,0,"PREDICTED: Rattus norvegicus tyrosyl-DNA phosphodiesterase 1 (Tdp1), transcript variant X1, mRNA","Q4G056",1219,0,"Tyrosyl-DNA phosphodiesterase 1",".",".",".",".","pfam06087","Tyr-DNA_phospho","Tyrosyl-DNA phosphodiesterase. Covalent intermediates between topoisomerase I and DNA can become dead-end complexes that lead to cell death. Tyrosyl-DNA phosphodiesterase can hydrolyse the bond between topoisomerase I and DNA.","GO:0000012|single strand break repair;GO:0006281|DNA repair;GO:0006302|double-strand break repair;GO:0008150|biological_process;GO:0090305|nucleic acid phosphodiester bond hydrolysis;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0003674|molecular_function;GO:0003690|double-stranded DNA binding;GO:0003697|single-stranded DNA binding;GO:0004527|exonuclease activity;GO:0017005|3'-tyrosyl-DNA phosphodiesterase activity;","K10862","TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]"]
["ENSRNOG00000009700",64,4.117148044,5,0.322809298,12.7541185,3.672891286,{"v":2.65966e-14,"d":"2.66E-14"},{"v":3.46096E-14,"d":"3.46E-14"},"up","yes","Dync1i1","protein_coding","chr4:33852927-34166149:+","gi|149064952|gb|EDM15028.1|",3249,0,"dynein cytoplasmic 1 intermediate chain 1, isoform CRA_c [Rattus norvegicus]","gi|11276090|ref|NM_019234.1|",2626,0,"Rattus norvegicus dynein cytoplasmic 1 intermediate chain 1 (Dync1i1), mRNA","Q63100",1249,0,"Cytoplasmic dynein 1 intermediate chain 1",".",".",".",".","pfam11540","Dynein_IC2","Cytoplasmic dynein 1 intermediate chain 2. Intermediate chain IC 2 forms part of the complex cytoplasmic dynein 1 along with a heavy chain (HC), two light intermediate chains (LICs) and three light chains (LCs). The complex is responsible for hydrolysing ATP to generate force toward the minus end of microtubules. IC binds to the HC via the N terminal binding domain on the HC and ICs contain binding sites for the LCs. The ICs are responsible for binding to kinetochores and the Golgi apparatus through an interaction with the p150Glued subunit of dynactin which is another complex.","GO:0007018|microtubule-based movement;GO:0007420|brain development;GO:0010970|transport along microtubule;GO:0047496|vesicle transport along microtubule;GO:0075733|intracellular transport of virus;","GO:0000776|kinetochore;GO:0000922|spindle pole;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005868|cytoplasmic dynein complex;GO:0005874|microtubule;GO:0031982|vesicle;GO:0036464|cytoplasmic ribonucleoprotein granule;GO:0048471|perinuclear region of cytoplasm;GO:0055037|recycling endosome;GO:1904115|axon cytoplasm;GO:1990257|piccolo-bassoon transport vesicle;","GO:0003777|microtubule motor activity;GO:0005515|protein binding;GO:0008017|microtubule binding;GO:0030507|spectrin binding;GO:0045503|dynein light chain binding;GO:0045504|dynein heavy chain binding;","K10415","DYNC1I, DNCI; dynein cytoplasmic 1 intermediate chain"]
["ENSRNOG00000068365",89,5.725408998,15,0.968427895,5.912065347,2.563662216,{"v":3.07183e-14,"d":"3.07E-14"},{"v":3.99095e-14,"d":"3.99E-14"},"up","yes","ENSRNOG00000068365","lncRNA","chr4:81647412-81648449:+",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","pfam04082","Fungal_trans","Fungal specific transcription factor domain.",".",".",".",".","."]
["ENSRNOG00000008489",189,12.15845282,69,4.454768316,2.729312044,1.448537348,{"v":3.27408e-14,"d":"3.27E-14"},{"v":4.24502E-14,"d":"4.25E-14"},"up","yes","Ppih","protein_coding","chr5:132906328-132924267:-","gi|148698503|gb|EDL30450.1|",946,{"v":1e-124,"d":"1.00E-124"},"mCG4207, isoform CRA_b, partial [Mus musculus]","gi|672019868|ref|XM_006225500.2|",1189,0,"PREDICTED: Rattus norvegicus peptidylprolyl isomerase H (cyclophilin H) (Ppih), transcript variant X3, mRNA","O43447",364,{"v":1e-124,"d":"1.00E-124"},"Peptidyl-prolyl cis-trans isomerase H","SPBC1709.04c",219,{"v":1e-68,"d":"1.00E-68"},"COG0652","pfam00160","Pro_isomerase","Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD. The peptidyl-prolyl cis-trans isomerases, also known as cyclophilins, share this domain of about 109 amino acids. Cyclophilins have been found in all organisms studied so far and catalyse peptidyl-prolyl isomerization during which the peptide bond preceding proline (the peptidyl-prolyl bond) is stabilized in the cis conformation. Mammalian cyclophilin A (CypA) is a major cellular target for the immunosuppressive drug cyclosporin A (CsA). Other roles for cyclophilins may include chaperone and cell signalling function.","GO:0000413|protein peptidyl-prolyl isomerization;GO:0006457|protein folding;GO:0008150|biological_process;GO:0045070|positive regulation of viral genome replication;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0016607|nuclear speck;GO:0043231|intracellular membrane-bounded organelle;GO:0046540|U4/U6 x U5 tri-snRNP complex;GO:0071001|U4/U6 snRNP;","GO:0003674|molecular_function;GO:0003755|peptidyl-prolyl cis-trans isomerase activity;GO:0016018|cyclosporin A binding;GO:0043021|ribonucleoprotein complex binding;","K09567","PPIH, CYPH; peptidyl-prolyl isomerase H (cyclophilin H) [EC:5.2.1.8]"]
["ENSRNOG00000030914",55,3.5381741,2,0.129123719,27.40142647,4.776179094,{"v":3.42291e-14,"d":"3.42E-14"},{"v":4.43195e-14,"d":"4.43E-14"},"up","yes","Lexm","protein_coding","chr5:121375998-121401869:-","gi|157824111|ref|NP_001102732.1|",2038,0,"uncharacterized protein C1orf177 homolog [Rattus norvegicus]","gi|240255464|ref|NM_001109262.2|",1950,0,"Rattus norvegicus lymphocyte expansion molecule (Lexm), mRNA","B1H283",789,0,"Lymphocyte expansion molecule",".",".",".",".","pfam07004","SHIPPO-rpt","Sperm-tail PG-rich repeat. This family represents a short conserved region carrying a PGP motif that is repeated in eukaryotic proteins of sperm-tails. Shippo orthologues from some species may include up to 40 Pro-Gly-Pro repeats.","GO:0008284|positive regulation of cell proliferation;GO:1903862|positive regulation of oxidative phosphorylation;","GO:0005739|mitochondrion;","GO:0097177|mitochondrial ribosome binding;",".","."]
["ENSRNOG00000070554",79,5.082104617,11,0.710180456,7.156075012,2.83916851,{"v":4.17581e-14,"d":"4.18E-14"},{"v":5.37875e-14,"d":"5.38E-14"},"up","yes","ENSRNOG00000070554","lncRNA","chr1:23123683-23127067:-","gi|149028494|gb|EDL83879.1|",225,{"v":8e-20,"d":"8.00E-20"},"rCG22859 [Rattus norvegicus]","gi|27545029|gb|AC091712.3|",734,0,"Rattus norvegicus strain Brown Norway clone RP31-64M17, complete sequence",".",".",".",".",".",".",".",".","pfam02093","Gag_p30","Gag P30 core shell protein. According to Swiss-Prot annotation this protein is the viral core shell protein. P30 is essential for viral assembly.",".",".",".",".","."]
["ENSRNOG00000020951",95,6.111391628,18,1.162113474,5.258859625,2.394749988,{"v":4.42659e-14,"d":"4.43E-14"},{"v":5.69535e-14,"d":"5.70E-14"},"up","yes","Slc4a1","protein_coding","chr10:87306872-87323117:-","gi|76443687|ref|NP_036783.2|",3965,0,"band 3 anion transport protein [Rattus norvegicus]","gi|55250403|gb|BC085748.1|",3538,0,"Rattus norvegicus solute carrier family 4 (anion exchanger), member 1, mRNA (cDNA clone MGC:93554 IMAGE:7126960), complete cds","P23562",1523,0,"Band 3 anion transport protein",".",".",".",".","pfam00955","HCO3_cotransp","HCO3- transporter family. This family contains Band 3 anion exchange proteins that exchange CL-/HCO3-. This family also includes cotransporters of Na+/HCO3-.","GO:0006820|anion transport;GO:0006821|chloride transport;GO:0007596|blood coagulation;GO:0007623|circadian rhythm;GO:0009414|response to water deprivation;GO:0010037|response to carbon dioxide;GO:0010446|response to alkaline pH;GO:0010447|response to acidic pH;GO:0014823|response to activity;GO:0015698|inorganic anion transport;GO:0015701|bicarbonate transport;GO:0017121|phospholipid scrambling;GO:0031667|response to nutrient levels;GO:0035811|negative regulation of urine volume;GO:0042102|positive regulation of T cell proliferation;GO:0042542|response to hydrogen peroxide;GO:0045852|pH elevation;GO:0046685|response to arsenic-containing substance;GO:0048821|erythrocyte development;GO:0050801|ion homeostasis;GO:0051354|negative regulation of oxidoreductase activity;GO:0051453|regulation of intracellular pH;GO:0055085|transmembrane transport;GO:0072659|protein localization to plasma membrane;GO:0098656|anion transmembrane transport;GO:1902476|chloride transmembrane transport;GO:1904539|negative regulation of glycolytic process through fructose-6-phosphate;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009898|cytoplasmic side of plasma membrane;GO:0009986|cell surface;GO:0014704|intercalated disc;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0030018|Z disc;GO:0030863|cortical cytoskeleton;","GO:0003779|actin binding;GO:0005452|inorganic anion exchanger activity;GO:0008022|protein C-terminus binding;GO:0015106|bicarbonate transmembrane transporter activity;GO:0015108|chloride transmembrane transporter activity;GO:0015301|anion:anion antiporter activity;GO:0019899|enzyme binding;GO:0022857|transmembrane transporter activity;GO:0030492|hemoglobin binding;GO:0030506|ankyrin binding;GO:0042803|protein homodimerization activity;GO:0044877|protein-containing complex binding;","K06573","SLC4A1, AE1, CD233; solute carrier family 4 (anion exchanger), member 1"]
["ENSRNOG00000001124",220,14.1526964,89,5.746005509,2.46304957,1.300445663,{"v":4.70798e-14,"d":"4.71E-14"},{"v":6.05329e-14,"d":"6.05E-14"},"up","yes","Rnft2","protein_coding","chr12:38329269-38387290:+","gi|537175625|gb|ERE74912.1|",2315,0,"RING finger and transmembrane domain-containing protein 2 [Cricetulus griseus]","gi|157820470|ref|NM_001107144.1|",4169,0,"Rattus norvegicus ring finger protein, transmembrane 2 (Rnft2), mRNA","Q3UF64",855,0,"RING finger and transmembrane domain-containing protein 2",".",".",".",".","pfam13639","zf-RING_2","Ring finger domain.","GO:0016567|protein ubiquitination;GO:1904294|positive regulation of ERAD pathway;","GO:0016021|integral component of membrane;","GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;",".","."]
["ENSRNOG00000065846",60,3.859826291,4,0.258247439,14.94623262,3.901709976,{"v":5.19407e-14,"d":"5.19E-14"},{"v":6.66777e-14,"d":"6.67E-14"},"up","yes","ENSRNOG00000065846","lncRNA","chr17:8578585-8627035:-",".",".",".",".","gi|77020544|gb|AC163338.5|",231,{"v":2e-115,"d":"2.00E-115"},"Mus musculus BAC clone RP24-574A13 from chromosome 13, complete sequence",".",".",".",".",".",".",".",".","pfam02445","NadA","Quinolinate synthetase A protein. Quinolinate synthetase catalyses the second step of the de novo biosynthetic pathway of pyridine nucleotide formation. In particular, quinolinate synthetase is involved in the condensation of dihydroxyacetone phosphate and iminoaspartate to form quinolinic acid. This synthesis requires two enzymes, a FAD-containing \"B protein\" and an \"A protein\".",".",".",".",".","."]
["ENSRNOG00000054311",81,5.210765493,12,0.774742316,6.725804679,2.749706883,{"v":5.26664e-14,"d":"5.27E-14"},{"v":6.75942e-14,"d":"6.76E-14"},"up","yes","ENSRNOG00000054311","lncRNA","chr12:36918224-36920511:-",".",".",".",".","gi|672026799|ref|XR_339554.2|",961,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102551526 (LOC102551526), ncRNA",".",".",".",".",".",".",".",".","pfam01027","Bax1-I","Inhibitor of apoptosis-promoting Bax1. Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner.",".",".",".",".","."]
["ENSRNOG00000027770",194,12.48010501,73,4.713015755,2.648008336,1.404907664,{"v":5.834e-14,"d":"5.83E-14"},{"v":7.47189e-14,"d":"7.47E-14"},"up","yes","Trpm3","protein_coding","chr1:219672892-220560717:+","gi|54144620|ref|NP_796315.2|",6689,0,"transient receptor potential cation channel subfamily M member 3 isoform f [Mus musculus]","gi|133892589|ref|NM_177341.4|",4542,0,"Mus musculus transient receptor potential cation channel, subfamily M, member 3 (Trpm3), transcript variant 6, mRNA","Q9HCF6",2498,0,"Transient receptor potential cation channel subfamily M member 3",".",".",".",".","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0006812|cation transport;GO:0016048|detection of temperature stimulus;GO:0050951|sensory perception of temperature stimulus;GO:0051262|protein tetramerization;GO:0098655|cation transmembrane transport;","GO:0005887|integral component of plasma membrane;","GO:0005227|calcium activated cation channel activity;GO:0005261|cation channel activity;","K04978","TRPM3; transient receptor potential cation channel subfamily M member 3"]
["ENSRNOG00000015465",250,16.08260955,109,7.037242702,2.28535667,1.192419341,{"v":5.95677e-14,"d":"5.96E-14"},{"v":7.62118e-14,"d":"7.62E-14"},"up","yes","Cep72","protein_coding","chr1:29225361-29255271:+","gi|109457649|ref|XP_217737.4|",3272,0,"PREDICTED: centrosomal protein of 72 kDa isoform X4 [Rattus norvegicus]","gi|672012596|ref|XM_001056326.5|",2447,0,"PREDICTED: Rattus norvegicus centrosomal protein 72 (Cep72), transcript variant X4, mRNA","Q9D3R3",1167,0,"Centrosomal protein of 72 kDa",".",".",".",".","pfam14580","LRR_9","Leucine-rich repeat.","GO:0007051|spindle organization;GO:0007099|centriole replication;GO:0033566|gamma-tubulin complex localization;GO:1904779|regulation of protein localization to centrosome;","GO:0005813|centrosome;GO:0034451|centriolar satellite;","GO:0042802|identical protein binding;","K16532","CEP72; centrosomal protein CEP72"]
["ENSRNOG00000014819",263,16.91890524,118,7.618299439,2.220824395,1.151095321,{"v":6.97643e-14,"d":"6.98E-14"},{"v":8.89388e-14,"d":"8.89E-14"},"up","yes","Hap1","protein_coding","chr10:85277890-85286126:-","gi|13162306|ref|NP_077047.1|",2474,0,"huntingtin-associated protein 1 isoform A [Rattus norvegicus]","gi|30061492|ref|NM_024133.2|",3602,0,"Rattus norvegicus huntingtin-associated protein 1 (Hap1), transcript variant 1, mRNA","P54256",916,0,"Huntingtin-associated protein 1",".",".",".",".","pfam04849","HAP1_N","HAP1 N-terminal conserved region. This family represents an N-terminal conserved region found in several huntingtin-associated protein 1 (HAP1) homologues. HAP1 binds to huntingtin in a polyglutamine repeat-length-dependent manner. However, its possible role in the pathogenesis of Huntington's disease is unclear. This family also includes a similar N-terminal conserved region from hypothetical protein products of ALS2CR3 genes found in the human juvenile amyotrophic lateral sclerosis critical region 2q33-2q34.","GO:0006605|protein targeting;GO:0006887|exocytosis;GO:0006914|autophagy;GO:0008089|anterograde axonal transport;GO:0008090|retrograde axonal transport;GO:0008104|protein localization;GO:0010976|positive regulation of neuron projection development;GO:0017157|regulation of exocytosis;GO:0021549|cerebellum development;GO:0021979|hypothalamus cell differentiation;GO:0022008|neurogenesis;GO:0030030|cell projection organization;GO:0031175|neuron projection development;GO:0031587|positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity;GO:0032230|positive regulation of synaptic transmission, GABAergic;GO:0032901|positive regulation of neurotrophin production;GO:0045022|early endosome to late endosome transport;GO:0045742|positive regulation of epidermal growth factor receptor signaling pathway;GO:0047496|vesicle transport along microtubule;GO:0048011|neurotrophin TRK receptor signaling pathway;GO:0048311|mitochondrion distribution;GO:0050769|positive regulation of neurogenesis;GO:0071363|cellular response to growth factor stimulus;GO:0090261|positive regulation of inclusion body assembly;GO:0098957|anterograde axonal transport of mitochondrion;GO:0099149|regulation of postsynaptic neurotransmitter receptor internalization;GO:1902430|negative regulation of amyloid-beta formation;GO:1902513|regulation of organelle transport along microtubule;GO:1902857|positive regulation of non-motile cilium assembly;","GO:0005634|nucleus;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005764|lysosome;GO:0005769|early endosome;GO:0005770|late endosome;GO:0005776|autophagosome;GO:0005783|endoplasmic reticulum;GO:0005813|centrosome;GO:0005814|centriole;GO:0005829|cytosol;GO:0008021|synaptic vesicle;GO:0016234|inclusion body;GO:0030425|dendrite;GO:0030426|growth cone;GO:0031410|cytoplasmic vesicle;GO:0043005|neuron projection;GO:0043197|dendritic spine;GO:0043679|axon terminus;GO:0048471|perinuclear region of cytoplasm;GO:0098982|GABA-ergic synapse;GO:0099523|presynaptic cytosol;GO:0099524|postsynaptic cytosol;GO:1904115|axon cytoplasm;","GO:0005102|signaling receptor binding;GO:0005515|protein binding;GO:0017022|myosin binding;GO:0019904|protein domain specific binding;GO:0042802|identical protein binding;GO:0044325|ion channel binding;GO:0048403|brain-derived neurotrophic factor binding;","K04647","HAP1; huntingtin-associated protein 1"]
["ENSRNOG00000039494",85,5.468087246,14,0.903866035,6.049665584,2.596855395,{"v":7.68549e-14,"d":"7.69E-14"},{"v":9.78035e-14,"d":"9.78E-14"},"up","yes","Aass","protein_coding","chr4:51606462-51663136:-","gi|155369281|ref|NP_001094433.1|",4813,0,"alpha-aminoadipic semialdehyde synthase, mitochondrial precursor [Rattus norvegicus]","gi|155369280|ref|NM_001100963.1|",3272,0,"Rattus norvegicus aminoadipate-semialdehyde synthase (Aass), mRNA","A2VCW9",1858,0,"Alpha-aminoadipic semialdehyde synthase, mitochondrial","YNR050c",322,{"v":8e-98,"d":"8.00E-98"},"COG1748","pfam03435","Saccharop_dh","Saccharopine dehydrogenase. This family comprised of three structural domains that can not be separated in the linear sequence. In some organisms this enzyme is found as a bifunctional polypeptide with lysine ketoglutarate reductase. The saccharopine dehydrogenase can also function as a saccharopine reductase.","GO:0008150|biological_process;GO:0019477|L-lysine catabolic process;GO:0019878|lysine biosynthetic process via aminoadipic acid;GO:0033512|L-lysine catabolic process to acetyl-CoA via saccharopine;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0043231|intracellular membrane-bounded organelle;","GO:0003674|molecular_function;GO:0004753|saccharopine dehydrogenase activity;GO:0047130|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity;GO:0047131|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity;","K14157","AASS; alpha-aminoadipic semialdehyde synthase [EC:1.5.1.8 1.5.1.9]"]
["ENSRNOG00000065578",286,18.39850532,134,8.651289194,2.126677875,1.088601527,{"v":8.30782e-14,"d":"8.31E-14"},{"v":1.05582E-13,"d":"1.06E-13"},"up","yes","ENSRNOG00000065578","lncRNA","chr6:9646577-9648597:-","gi|537170863|gb|ERE74260.1|",231,{"v":4e-20,"d":"4.00E-20"},"hypothetical protein H671_5g13563 [Cricetulus griseus]","gi|396941654|ref|NM_001270620.1|",337,{"v":2E-174,"d":"2.00E-174"},"Rattus norvegicus protein phosphatase, Mg2+/Mn2+ dependent, 1B (Ppm1b), transcript variant 3, mRNA",".",".",".",".",".",".",".",".","pfam02284","COX5A","Cytochrome c oxidase subunit Va. Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of cytochrome c oxidase subunit Va.",".",".",".",".","."]
["ENSRNOG00000032327",209,13.44506158,83,5.358634351,2.509046279,1.327139081,{"v":8.32412e-14,"d":"8.32E-14"},{"v":1.05766E-13,"d":"1.06E-13"},"up","yes","Pdia5","protein_coding","chr11:65272155-65359084:+","gi|62078977|ref|NP_001014147.1|",2580,0,"protein disulfide-isomerase A5 precursor [Rattus norvegicus]","gi|62078976|ref|NM_001014125.1|",1739,0,"Rattus norvegicus protein disulfide isomerase family A, member 5 (Pdia5), mRNA","Q5I0H9",1000,0,"Protein disulfide-isomerase A5","SPAC17H9.14c",84.3,{"v":7e-17,"d":"7.00E-17"},"COG0526","pfam00085","Thioredoxin","Thioredoxin. Thioredoxins are small enzymes that participate in redox reactions, via the reversible oxidation of an active centre disulfide bond. Some members with only the active site are not separated from the noise.","GO:0006457|protein folding;","GO:0005788|endoplasmic reticulum lumen;","GO:0003756|protein disulfide isomerase activity;GO:0015035|protein disulfide oxidoreductase activity;","K09583","PDIA5; protein disulfide-isomerase A5 [EC:5.3.4.1]"]
["ENSRNOG00000025108",133,8.555948279,38,2.453350667,3.487454278,1.802174303,{"v":9.50403e-14,"d":"9.50E-14"},{"v":1.20543E-13,"d":"1.21E-13"},"up","yes","Ankrd35","protein_coding","chr2:184207071-184227063:+","gi|564300719|ref|XP_006224285.1|",3749,0,"PREDICTED: ankyrin repeat domain-containing protein 35 isoform X2 [Rattus norvegicus]","gi|672016109|ref|XM_001063190.5|",3363,0,"PREDICTED: Rattus norvegicus ankyrin repeat domain 35 (Ankrd35), transcript variant X1, mRNA",".",".",".",".","all2748",92.8,{"v":7e-19,"d":"7.00E-19"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).",".",".",".",".","."]
["ENSRNOG00000033321",178,11.450818,64,4.131959018,2.771280632,1.470552812,{"v":9.59645E-14,"d":"9.60E-14"},{"v":1.21661e-13,"d":"1.22E-13"},"up","yes","Hmgb2l1","protein_coding","chr11:47252569-47253669:-","gi|625292335|ref|XP_007637920.1|",948,{"v":1e-122,"d":"1.00E-122"},"PREDICTED: high mobility group protein B2 isoform X2 [Cricetulus griseus]","gi|564376626|ref|XM_573272.5|",1087,0,"PREDICTED: Rattus norvegicus high mobility group box 2-like 1 (Hmgb2l1), mRNA","P52925",346,{"v":2e-117,"d":"2.00E-117"},"High mobility group protein B2","YPR052c",65.9,{"v":2E-12,"d":"2.00E-12"},"COG5648","pfam09011","HMG_box_2","HMG-box domain. This short 71 residue domain is an HMG-box domain. HMG-box domains mediate re-modelling of chromatin-structure. Mammalian HMG-box proteins are of two types: those that are non-sequence-specific DNA-binding proteins with two HMG-box domains and a long highly acidic C-tail; and a diverse group of sequence-specific transcription factor-proteins with either a single HMG-box or up to six copies, and no acidic C-tail.","GO:0001938|positive regulation of endothelial cell proliferation;GO:0002437|inflammatory response to antigenic stimulus;GO:0006265|DNA topological change;GO:0006310|DNA recombination;GO:0006334|nucleosome assembly;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007283|spermatogenesis;GO:0007289|spermatid nucleus differentiation;GO:0007399|nervous system development;GO:0008150|biological_process;GO:0008584|male gonad development;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0031100|animal organ regeneration;GO:0032075|positive regulation of nuclease activity;GO:0032496|response to lipopolysaccharide;GO:0032728|positive regulation of interferon-beta production;GO:0043388|positive regulation of DNA binding;GO:0045087|innate immune response;GO:0045089|positive regulation of innate immune response;GO:0045648|positive regulation of erythrocyte differentiation;GO:0045654|positive regulation of megakaryocyte differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048545|response to steroid hormone;GO:0050767|regulation of neurogenesis;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:0050918|positive chemotaxis;GO:0051054|positive regulation of DNA metabolic process;GO:0060326|cell chemotaxis;GO:0071222|cellular response to lipopolysaccharide;GO:0072091|regulation of stem cell proliferation;GO:1902042|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;","GO:0000785|chromatin;GO:0000793|condensed chromosome;GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0032991|protein-containing complex;GO:0048471|perinuclear region of cytoplasm;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000987|proximal promoter sequence-specific DNA binding;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0003684|damaged DNA binding;GO:0003690|double-stranded DNA binding;GO:0003697|single-stranded DNA binding;GO:0003713|transcription coactivator activity;GO:0008289|lipid binding;GO:0008301|DNA binding, bending;GO:0019904|protein domain specific binding;GO:0031493|nucleosomal histone binding;GO:0042056|chemoattractant activity;GO:0044378|non-sequence-specific DNA binding, bending;GO:0050786|RAGE receptor binding;GO:0097100|supercoiled DNA binding;","K11295","HMGB2; high mobility group protein B2"]
["ENSRNOG00000011775",186,11.9654615,69,4.454768316,2.68598963,1.425453735,{"v":1.03556E-13,"d":"1.04E-13"},{"v":1.30966e-13,"d":"1.31E-13"},"up","yes","Mfap3l","protein_coding","chr16:29415849-29430863:-","gi|148696689|gb|EDL28636.1|",2166,0,"microfibrillar-associated protein 3-like, isoform CRA_b, partial [Mus musculus]","gi|58865673|ref|NM_001012049.1|",1925,0,"Rattus norvegicus microfibrillar-associated protein 3-like (Mfap3l), mRNA","Q6AYP2",801,0,"Microfibrillar-associated protein 3-like",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.",".","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030054|cell junction;",".","K25408","MFAP3L; microfibrillar-associated protein 3-like"]
["ENSRNOG00000014642",215,13.83104421,88,5.68144365,2.434424252,1.283580612,{"v":1.60122E-13,"d":"1.60E-13"},{"v":2.0077e-13,"d":"2.01E-13"},"up","yes","Morn1","protein_coding","chr5:165646991-165704892:+","gi|53850616|ref|NP_001005544.1|",2522,0,"MORN repeat-containing protein 1 [Rattus norvegicus]","gi|53850615|ref|NM_001005544.1|",1607,0,"Rattus norvegicus MORN repeat containing 1 (Morn1), mRNA",".",".",".",".","slr1485",91.7,{"v":2E-19,"d":"2.00E-19"},"COG4642","pfam02493","MORN","MORN repeat. The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22).  #=GF CC   A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesised to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.",".",".",".",".","."]
["ENSRNOG00000067409",165,10.6145223,57,3.680026,2.884360681,1.528251581,{"v":1.6258E-13,"d":"1.63E-13"},{"v":2.03762E-13,"d":"2.04E-13"},"up","yes","Cfap299","protein_coding","chr14:10787203-11272943:-","gi|66841374|ref|NP_001019785.1|",1195,{"v":3e-163,"d":"3.00E-163"},"uncharacterized protein C4orf22 homolog [Mus musculus]","gi|66841373|ref|NM_001024614.1|",635,0,"Mus musculus RIKEN cDNA 1700007G11 gene (1700007G11Rik), mRNA",".",".",".",".",".",".",".",".","pfam14713","DUF4464","Domain of unknown function (DUF4464). This family of proteins is found in eukaryotes. Proteins in this family are typically between 224 and 241 amino acids in length. There is a conserved YID sequence motif.",".",".",".",".","."]
["ENSRNOG00000012665",218,14.02403552,90,5.810567369,2.413539786,1.271150609,{"v":1.65976E-13,"d":"1.66E-13"},{"v":2.07836e-13,"d":"2.08E-13"},"up","yes","Nmrk1","protein_coding","chr1:216049437-216076791:+","gi|66730337|ref|NP_001019463.1|",1050,{"v":2e-138,"d":"2.00E-138"},"nicotinamide riboside kinase 1 [Rattus norvegicus]","gi|66730336|ref|NM_001024292.1|",1566,0,"Rattus norvegicus nicotinamide riboside kinase 1 (Nmrk1), mRNA","Q6AY91",409,{"v":7e-140,"d":"7.00E-140"},"Nicotinamide riboside kinase 1","SPBP22H7.06",71.2,{"v":3e-13,"d":"3.00E-13"},"COG0572","pfam13238","AAA_18","AAA domain.","GO:0008150|biological_process;GO:0009435|NAD biosynthetic process;GO:0016310|phosphorylation;","GO:0005575|cellular_component;GO:0005737|cytoplasm;","GO:0003674|molecular_function;GO:0005524|ATP binding;GO:0046872|metal ion binding;GO:0050262|ribosylnicotinamide kinase activity;GO:0061769|ribosylnicotinate kinase activity;","K10524","NRK1_2; nicotinamide/nicotinate riboside kinase [EC:2.7.1.22 2.7.1.173]"]
["ENSRNOG00000011112",137,8.813270031,41,2.647036246,3.329485966,1.735299459,{"v":1.79649E-13,"d":"1.80E-13"},{"v":2.24809e-13,"d":"2.25E-13"},"up","yes","Fam161b","protein_coding","chr6:103992170-104018776:-","gi|149025130|gb|EDL81497.1|",2691,0,"rCG20883 [Rattus norvegicus]","gi|672020966|ref|XR_601531.1|",1978,0,"PREDICTED: Rattus norvegicus family with sequence similarity 161, member B (Fam161b), misc_RNA","Q8CB59",950,0,"Protein FAM161B",".",".",".",".","pfam10595","UPF0564","Uncharacterized protein family UPF0564. This family of proteins has no known function. However, one of the members is annotated as an EF-hand family protein.","GO:0044782|cilium organization;","GO:0005881|cytoplasmic microtubule;GO:0005929|cilium;GO:0015630|microtubule cytoskeleton;",".",".","."]
["ENSRNOG00000033776",135,8.684609155,40,2.582474386,3.362902339,1.749706883,{"v":1.96004e-13,"d":"1.96E-13"},{"v":2.44633E-13,"d":"2.45E-13"},"up","yes","ENSRNOG00000033776","protein_coding","chr6:73242608-73253291:-","gi|1706910|sp|P49945.2|FRIL2_MOUSE",854,{"v":2E-107,"d":"2.00E-107"},"RecName: Full=Ferritin light chain 2; AltName: Full=Ferritin L subunit 2; AltName: Full=Ferritin subunit LG","gi|672020722|ref|XR_601444.1|",921,0,"PREDICTED: Rattus norvegicus ferritin light chain 2 (LOC100359668), misc_RNA","P49945",333,{"v":6e-109,"d":"6.00E-109"},"Ferritin light chain 2",".",".",".",".","pfam00210","Ferritin","Ferritin-like domain. This family contains ferritins and other ferritin-like proteins such as members of the DPS family and bacterioferritins.","GO:0006826|iron ion transport;GO:0006880|intracellular sequestering of iron ion;","GO:0005737|cytoplasm;","GO:0008198|ferrous iron binding;GO:0008199|ferric iron binding;",".","."]
["ENSRNOG00000014465",267,17.176227,123,7.941108738,2.162950737,1.113000807,{"v":2.07821e-13,"d":"2.08E-13"},{"v":2.59042e-13,"d":"2.59E-13"},"up","yes","Oca2","protein_coding","chr1:107116278-107446074:+","gi|407339767|ref|NP_001258422.1|",3858,0,"P protein [Rattus norvegicus]","gi|407339766|ref|NM_001271493.1|",2733,0,"Rattus norvegicus pink-eyed dilution-like (LOC100365773), mRNA","Q62052",1390,0,"P protein","TM0934",118,{"v":3e-27,"d":"3.00E-27"},"COG1055","pfam03600","CitMHS","Citrate transporter.","GO:0007286|spermatid development;GO:0008150|biological_process;GO:0008283|cell proliferation;GO:0030318|melanocyte differentiation;GO:0042438|melanin biosynthetic process;GO:0043473|pigmentation;GO:0048066|developmental pigmentation;GO:0055085|transmembrane transport;","GO:0005575|cellular_component;GO:0005765|lysosomal membrane;GO:0005789|endoplasmic reticulum membrane;GO:0010008|endosome membrane;GO:0016021|integral component of membrane;GO:0033162|melanosome membrane;","GO:0003674|molecular_function;","K24200","OCA2; P protein"]
["ENSRNOG00000038413",51,3.280852347,0,0.03228093,101.6343818,6.667244723,{"v":2.08363E-13,"d":"2.08E-13"},{"v":2.59604e-13,"d":"2.60E-13"},"up","yes","Olr1433","protein_coding","chr10:43037857-43046701:+","gi|47576039|ref|NP_001000525.1|",1491,0,"olfactory receptor Olr1433 [Rattus norvegicus]","gi|34849931|gb|AC109605.14|",1186,0,"Mus musculus strain 129S6/SvEvTac clone rp22-470o15 map 11, complete sequence","Q7Z3T1",459,{"v":7e-152,"d":"7.00E-152"},"Olfactory receptor 2W3",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0050911|detection of chemical stimulus involved in sensory perception of smell;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004984|olfactory receptor activity;","K04257","OLFR; olfactory receptor"]
["ENSRNOG00000065794",149,9.58523529,48,3.098969263,3.093039806,1.6290254,{"v":2.09567e-13,"d":"2.10E-13"},{"v":2.61047e-13,"d":"2.61E-13"},"up","yes","Mafk","lncRNA","chr12:14832249-14858888:-","gi|149035030|gb|EDL89750.1|",720,{"v":1E-83,"d":"1.00E-83"},"v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) [Rattus norvegicus]","gi|47575873|ref|NM_145673.2|",2646,0,"Rattus norvegicus v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K (Mafk), mRNA","Q61827",268,{"v":1e-80,"d":"1.00E-80"},"Transcription factor MafK",".",".",".",".","pfam03131","bZIP_Maf","bZIP Maf transcription factor. Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerization and DNA binding property. Thus, this family is probably related to pfam00170. This family also includes the DNA_binding domain of Skn-1, this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer.",".",".",".",".","."]
["ENSRNOG00000001874",170,10.93617449,61,3.938273439,2.776895678,1.473472979,{"v":3.14953E-13,"d":"3.15E-13"},{"v":3.89349e-13,"d":"3.89E-13"},"up","yes","Slc7a4","protein_coding","chr11:83435211-83438881:+","gi|157819067|ref|NP_001100548.1|",2615,0,"cationic amino acid transporter 4 [Rattus norvegicus]","gi|672071714|ref|XM_006248697.2|",2465,0,"PREDICTED: Rattus norvegicus solute carrier family 7, member 4 (Slc7a4), transcript variant X4, mRNA","Q8BLQ7",991,0,"Cationic amino acid transporter 4","BS_yfnA",183,{"v":3E-49,"d":"3.00E-49"},"COG0531","pfam13520","AA_permease_2","Amino acid permease.","GO:0003333|amino acid transmembrane transport;GO:0006865|amino acid transport;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0015171|amino acid transmembrane transporter activity;","K13866","SLC7A4; solute carrier family 7 (cationic amino acid transporter), member 4"]
["ENSRNOG00000023366",165,10.6145223,58,3.74458786,2.834630324,1.5031606,{"v":3.1706e-13,"d":"3.17E-13"},{"v":3.91674e-13,"d":"3.92E-13"},"up","yes","Styxl1","protein_coding","chr12:20907435-20939752:+","gi|564378957|ref|XP_006249242.1|",1621,0,"PREDICTED: serine/threonine/tyrosine-interacting-like protein 1 isoform X1 [Rattus norvegicus]","gi|672072688|ref|XM_006249180.2|",1460,0,"PREDICTED: Rattus norvegicus serine/threonine/tyrosine interacting-like 1 (Styxl1), transcript variant X1, mRNA","Q9Y6J8",439,{"v":2E-150,"d":"2.00E-150"},"Serine/threonine/tyrosine-interacting-like protein 1",".",".",".",".","pfam00782","DSPc","Dual specificity phosphatase, catalytic domain. Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a \"recognition\" region.","GO:0006470|protein dephosphorylation;GO:0010976|positive regulation of neuron projection development;GO:0032515|negative regulation of phosphoprotein phosphatase activity;GO:0062030|negative regulation of stress granule assembly;GO:2001242|regulation of intrinsic apoptotic signaling pathway;GO:2001244|positive regulation of intrinsic apoptotic signaling pathway;","GO:0005739|mitochondrion;","GO:0001691|pseudophosphatase activity;GO:0004864|protein phosphatase inhibitor activity;GO:0008138|protein tyrosine/serine/threonine phosphatase activity;GO:0019903|protein phosphatase binding;","K18047","STYXL1, DUSP24, MKSTYX; serine/threonine/tyrosine-interacting-like protein 1"]
["ENSRNOG00000056819",231,14.86033122,100,6.456185966,2.301719823,1.202712232,{"v":3.66536e-13,"d":"3.67E-13"},{"v":4.50872e-13,"d":"4.51E-13"},"up","yes","Susd1","protein_coding","chr5:74157773-74276291:-","gi|261598994|ref|NP_001156760.2|",3332,0,"sushi domain-containing protein 1 precursor [Mus musculus]","gi|672019394|ref|XM_008775964.1|",2071,0,"PREDICTED: Rattus norvegicus sushi domain containing 1 (Susd1), transcript variant X3, mRNA","Q6UWL2",1033,0,"Sushi domain-containing protein 1",".",".",".",".","pfam12947","EGF_3","EGF domain. This family includes a variety of EGF-like domain homologues. This family includes the C-terminal domain of the malaria parasite MSP1 protein.",".",".","GO:0005509|calcium ion binding;","K23819","SUSD1; sushi domain-containing protein 1"]
["ENSRNOG00000037079",243,15.63229648,108,6.972680843,2.241934893,1.164744382,{"v":3.70022e-13,"d":"3.70E-13"},{"v":4.54867e-13,"d":"4.55E-13"},"up","yes","Padi6","protein_coding","chr5:153021965-153037414:-","gi|672054422|ref|XP_008762454.1|",3690,0,"PREDICTED: protein-arginine deiminase type-6 isoform X1 [Rattus norvegicus]","gi|672054421|ref|XM_008764232.1|",2230,0,"PREDICTED: Rattus norvegicus peptidyl arginine deiminase, type VI (Padi6), transcript variant X1, mRNA","Q8K3V4",1192,0,"Protein-arginine deiminase type-6",".",".",".",".","pfam03068","PAD","Protein-arginine deiminase (PAD). Members of this family are found in mammals. In the presence of calcium ions, PAD enzymes EC:3.5.3.15 catalyse the post-translational modification reaction responsible for the formation of citrulline residues: Protein L-arginine + H2O <=> Protein L-citrulline + NH3. Several types are recognized (and included in the family) on the basis of molecular mass, substrate specificity, and tissue localisation. The expression of type I PAD is known to be under the control of oestrogen.","GO:0007010|cytoskeleton organization;GO:0007028|cytoplasm organization;GO:0018101|protein citrullination;GO:0034613|cellular protein localization;GO:0036414|histone citrullination;GO:0040016|embryonic cleavage;GO:0043143|regulation of translation by machinery localization;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0045111|intermediate filament cytoskeleton;GO:0060473|cortical granule;","GO:0004668|protein-arginine deiminase activity;GO:0005509|calcium ion binding;","K01481","E3.5.3.15; protein-arginine deiminase [EC:3.5.3.15]"]
["ENSRNOG00000003280",115,7.398000391,30,1.93685579,3.819592781,1.933418836,{"v":3.79709e-13,"d":"3.80E-13"},{"v":4.66674e-13,"d":"4.67E-13"},"up","yes","Grin2c","protein_coding","chr10:100488431-100506427:-","gi|148747563|ref|NP_036707.3|",6015,0,"glutamate receptor ionotropic, NMDA 2C [Rattus norvegicus]","gi|564375186|ref|XM_006247707.1|",4669,0,"PREDICTED: Rattus norvegicus glutamate receptor, ionotropic, N-methyl D-aspartate 2C (Grin2c), transcript variant X2, mRNA","Q00961",2311,0,"Glutamate receptor ionotropic, NMDA 2C",".",".",".",".","pfam00060","Lig_chan","Ligand-gated ion channel. This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.","GO:0009611|response to wounding;GO:0019722|calcium-mediated signaling;GO:0033058|directional locomotion;GO:0035235|ionotropic glutamate receptor signaling pathway;GO:0042177|negative regulation of protein catabolic process;GO:0042391|regulation of membrane potential;GO:0050885|neuromuscular process controlling balance;GO:0060079|excitatory postsynaptic potential;GO:0060291|long-term synaptic potentiation;GO:0097553|calcium ion transmembrane import into cytosol;GO:1903539|protein localization to postsynaptic membrane;","GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0017146|NMDA selective glutamate receptor complex;GO:0045211|postsynaptic membrane;GO:0098839|postsynaptic density membrane;GO:0098978|glutamatergic synapse;","GO:0004970|ionotropic glutamate receptor activity;GO:0004972|NMDA glutamate receptor activity;GO:0005261|cation channel activity;GO:0005515|protein binding;GO:0015276|ligand-gated ion channel activity;GO:0022849|glutamate-gated calcium ion channel activity;GO:0030165|PDZ domain binding;GO:0038023|signaling receptor activity;GO:0047485|protein N-terminus binding;GO:1904315|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K05211","GRIN2C; glutamate receptor ionotropic, NMDA 2C"]
["ENSRNOG00000021029",75,4.824782864,11,0.710180456,6.7937421,2.764206453,{"v":3.84299e-13,"d":"3.84E-13"},{"v":4.72214e-13,"d":"4.72E-13"},"up","yes","Hamp","protein_coding","chr1:86170901-86172891:-","gi|16758218|ref|NP_445921.1|",249,{"v":5e-25,"d":"5.00E-25"},"hepcidin precursor [Rattus norvegicus]","gi|298914155|emb|FQ222617.1|",411,0,"Rattus norvegicus TL0ADA20YP17 mRNA sequence","Q99MH3",100,{"v":2e-26,"d":"2.00E-26"},"Hepcidin",".",".",".",".","pfam06446","Hepcidin","Hepcidin. Hepcidin is a antibacterial and antifungal protein expressed in the liver and is also a signaling molecule in iron metabolizm. The hepcidin protein is cysteine-rich and forms a distorted beta-sheet with an unusual disulphide bond found at the turn of the hairpin.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0002092|positive regulation of receptor internalization;GO:0002262|myeloid cell homeostasis;GO:0006879|cellular iron ion homeostasis;GO:0006953|acute-phase response;GO:0007259|JAK-STAT cascade;GO:0007568|aging;GO:0010039|response to iron ion;GO:0010043|response to zinc ion;GO:0031640|killing of cells of other organism;GO:0032413|negative regulation of ion transmembrane transporter activity;GO:0033189|response to vitamin A;GO:0034760|negative regulation of iron ion transmembrane transport;GO:0036017|response to erythropoietin;GO:0042742|defense response to bacterium;GO:0043032|positive regulation of macrophage activation;GO:0045471|response to ethanol;GO:0045779|negative regulation of bone resorption;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050728|negative regulation of inflammatory response;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:0050832|defense response to fungus;GO:0055072|iron ion homeostasis;GO:0060586|multicellular organismal iron ion homeostasis;GO:0061051|positive regulation of cell growth involved in cardiac muscle cell development;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0071222|cellular response to lipopolysaccharide;GO:0071354|cellular response to interleukin-6;GO:0071356|cellular response to tumor necrosis factor;GO:0071481|cellular response to X-ray;GO:0097421|liver regeneration;GO:1902916|positive regulation of protein polyubiquitination;GO:1903364|positive regulation of cellular protein catabolic process;GO:1903413|cellular response to bile acid;GO:1904039|negative regulation of ferrous iron export;GO:1904255|negative regulation of iron channel activity;GO:1904479|negative regulation of intestinal absorption;GO:1990641|response to iron ion starvation;GO:2000646|positive regulation of receptor catabolic process;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0014704|intercalated disc;GO:0045179|apical cortex;","GO:0003674|molecular_function;GO:0005102|signaling receptor binding;GO:0005179|hormone activity;GO:0005507|copper ion binding;GO:0097690|iron channel inhibitor activity;","K23106","HAMP; hepcidin"]
["ENSRNOG00000067168",137,8.813270031,42,2.711598106,3.25021249,1.700534041,{"v":3.89343E-13,"d":"3.89E-13"},{"v":4.78103e-13,"d":"4.78E-13"},"up","yes","Prelid2","protein_coding","chr18:33873599-33961225:-","gi|404501506|ref|NP_001258262.1|",882,{"v":3e-112,"d":"3.00E-112"},"PRELI domain-containing protein 2 [Rattus norvegicus]","gi|404501505|ref|NM_001271333.1|",497,0,"Rattus norvegicus PRELI domain containing 2 (Prelid2), mRNA","Q0VBB0",343,{"v":1e-113,"d":"1.00E-113"},"PRELI domain-containing protein 2",".",".",".",".","pfam04707","PRELI","PRELI-like family. This family includes a conserved region found in the PRELI protein and yeast YLR168C gene MSF1 product. The function of this protein is unknown, though it is thought to be involved in intra-mitochondrial protein sorting. This region is also found in a number of other eukaryotic proteins.",".",".",".",".","."]
["ENSRNOG00000032729",256,16.46859218,117,7.55373758,2.180191197,1.124454661,{"v":4.15559e-13,"d":"4.16E-13"},{"v":5.09858e-13,"d":"5.10E-13"},"up","yes","ENSRNOG00000032729","protein_coding","chrX:99019000-99021503:-","gi|116829778|ref|NP_001070903.1|",570,{"v":6e-67,"d":"6.00E-67"},"protein BEX2 [Rattus norvegicus]","gi|22213663|emb|AL671914.9|",838,0,"Mouse DNA sequence from clone RP23-1A3 on chromosome X, complete sequence","Q3MKQ1",224,{"v":2e-68,"d":"2.00E-68"},"Protein BEX2",".",".",".",".","pfam04538","BEX","Brain expressed X-linked like family. This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.","GO:0006915|apoptotic process;GO:0007165|signal transduction;GO:0042981|regulation of apoptotic process;GO:0051726|regulation of cell cycle;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0005102|signaling receptor binding;",".","."]
["ENSRNOG00000013872",174,11.19349624,64,4.131959018,2.709004662,1.437762876,{"v":4.51823E-13,"d":"4.52E-13"},{"v":5.54112e-13,"d":"5.54E-13"},"up","yes","P2ry14","protein_coding","chr2:143372697-143413141:-","gi|564336567|ref|XP_006232458.1|",1685,0,"PREDICTED: P2Y purinoceptor 14 isoform X1 [Rattus norvegicus]","gi|672042325|ref|XM_006232396.2|",1659,0,"PREDICTED: Rattus norvegicus purinergic receptor P2Y, G-protein coupled, 14 (P2ry14), transcript variant X2, mRNA","Q9ESG6",593,0,"P2Y purinoceptor 14",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0006955|immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0035589|G protein-coupled purinergic nucleotide receptor signaling pathway;GO:0061484|hematopoietic stem cell homeostasis;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0045028|G protein-coupled purinergic nucleotide receptor activity;","K04299","P2RY14; P2Y purinoceptor 14"]
["ENSRNOG00000018505",255,16.40426174,117,7.55373758,2.171674825,1.118808098,{"v":5.72271e-13,"d":"5.72E-13"},{"v":6.97486E-13,"d":"6.97E-13"},"up","yes","Cidea","protein_coding","chr18:60894874-60920481:+","gi|281427180|ref|NP_001163938.1|",997,{"v":1e-130,"d":"1.00E-130"},"cell death activator CIDE-A [Rattus norvegicus]","gi|281427179|ref|NM_001170467.1|",870,0,"Rattus norvegicus cell death-inducing DFFA-like effector a (Cidea), mRNA","O70302",359,{"v":1e-120,"d":"1.00E-120"},"Cell death activator CIDE-A",".",".",".",".","pfam02017","CIDE-N","CIDE-N domain. This domain is found in CAD nuclease, and in ICAD, the inhibitor of CAD nuclease. The two proteins interact through this domain.","GO:0001659|temperature homeostasis;GO:0001818|negative regulation of cytokine production;GO:0006629|lipid metabolic process;GO:0006915|apoptotic process;GO:0008150|biological_process;GO:0008219|cell death;GO:0010890|positive regulation of sequestering of triglyceride;GO:0019915|lipid storage;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0032720|negative regulation of tumor necrosis factor production;GO:0035634|response to stilbenoid;GO:0042981|regulation of apoptotic process;GO:0050995|negative regulation of lipid catabolic process;GO:0070417|cellular response to cold;GO:0120163|negative regulation of cold-induced thermogenesis;GO:1900118|negative regulation of execution phase of apoptosis;GO:1902510|regulation of apoptotic DNA fragmentation;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005740|mitochondrial envelope;GO:0005811|lipid droplet;","GO:0003674|molecular_function;GO:0042803|protein homodimerization activity;",".","."]
["ENSRNOG00000046971",94,6.047061189,20,1.291237193,4.683152888,2.227480137,{"v":6.52973e-13,"d":"6.53E-13"},{"v":7.94151e-13,"d":"7.94E-13"},"up","yes","Ccer2","protein_coding","chr1:84043328-84046228:+","gi|672013308|ref|XP_008772694.1|",882,{"v":2E-113,"d":"2.00E-113"},"PREDICTED: coiled-coil domain-containing glutamate-rich protein 2 [Rattus norvegicus]","gi|672013307|ref|XM_008774472.1|",1213,0,"PREDICTED: Rattus norvegicus coiled-coil glutamate-rich protein 2 (Ccer2), mRNA","I3L3R5",175,{"v":6e-50,"d":"6.00E-50"},"Coiled-coil domain-containing glutamate-rich protein 2",".",".",".",".","pfam15358","TSKS","Testis-specific serine kinase substrate. TSKS, testis-specific serine kinase substrate, is expressed in the testis and is downregulated in cancerous testicular tissue, in comparison with adjacent normal tissue. TSKS expression is very low to undetectable in seminoma, teratocarcinoma, embryonal, and Leydig cell tumors, while high in testicular tissue adjacent to tumors which contain pre-malignant carcinoma in situ. Recently it has been shown in human testis to be localized to the equatorial segment of ejaculated human sperm. The finding of a TSKS family member in mature sperm suggests that this family of kinases might play a role in sperm function. TSKS is localized during spermiogenesis to the centrioles of post-meiotic spermatids, where it reaches its greatest concentration during the period of flagellogenesis.",".",".",".",".","."]
["ENSRNOG00000000201",81,5.210765493,14,0.903866035,5.764975439,2.527314461,{"v":6.56218e-13,"d":"6.56E-13"},{"v":7.97927E-13,"d":"7.98E-13"},"up","yes","Gsta5","protein_coding","chr8:79105661-79117472:+","gi|58331251|ref|NP_001010921.1|",1171,{"v":3E-160,"d":"3.00E-160"},"glutathione S-transferase alpha-2 [Rattus norvegicus]","gi|672061818|ref|XM_006243421.2|",830,0,"PREDICTED: Rattus norvegicus glutathione S-transferase alpha 2 (Gsta2), transcript variant X1, mRNA","P04903",452,{"v":1e-160,"d":"1.00E-160"},"Glutathione S-transferase alpha-2","AGc1530",52.8,2e-07,"COG0625","pfam00043","GST_C","Glutathione S-transferase, C-terminal domain. GST conjugates reduced glutathione to a variety of targets including S-crystallin from squid, the eukaryotic elongation factor 1-gamma, the HSP26 family of stress-related proteins and auxin-regulated proteins in plants. Stringent starvation proteins in Escherichia coli are also included in the alignment but are not known to have GST activity.     The glutathione molecule binds in a cleft between N and C-terminal domains. The catalytically important residues are proposed to reside in the N-terminal domain. In plants, GSTs are encoded by a large gene family (48 GST genes in Arabidopsis) and can be divided into the phi, tau, theta, zeta, and lambda classes.","GO:0006693|prostaglandin metabolic process;GO:0006749|glutathione metabolic process;GO:0006805|xenobiotic metabolic process;GO:0007568|aging;GO:0009617|response to bacterium;GO:0030855|epithelial cell differentiation;GO:0035634|response to stilbenoid;GO:0042178|xenobiotic catabolic process;GO:0098869|cellular oxidant detoxification;GO:1901687|glutathione derivative biosynthetic process;","GO:0005829|cytosol;","GO:0004364|glutathione transferase activity;GO:0004769|steroid delta-isomerase activity;GO:0035731|dinitrosyl-iron complex binding;GO:0042803|protein homodimerization activity;GO:0043295|glutathione binding;","K00799","GST, gst; glutathione S-transferase [EC:2.5.1.18]"]
["ENSRNOG00000016222",69,4.438800235,9,0.581056737,7.639185561,2.933418836,{"v":7.1127e-13,"d":"7.11E-13"},{"v":8.6303e-13,"d":"8.63E-13"},"up","yes","Ppp1r3g","protein_coding","chr17:28876482-28877525:-","gi|564319774|ref|XP_006222440.1|",1534,0,"PREDICTED: protein phosphatase 1 regulatory subunit 3G [Rattus norvegicus]","gi|564319773|ref|XM_006222378.1|",1044,0,"PREDICTED: Rattus norvegicus protein phosphatase 1, regulatory subunit 3G (Ppp1r3g), mRNA","Q9CW07",526,0,"Protein phosphatase 1 regulatory subunit 3G",".",".",".",".","pfam03370","CBM_21","Putative phosphatase regulatory subunit. This family consists of several eukaryotic proteins that are thought to be involved in the regulation of glycogen metabolizm. For instance, the mouse PTG protein has been shown to interact with glycogen synthase, phosphorylase kinase, phosphorylase a: these three enzymes have key roles in the regulation of glycogen metabolizm. PTG also binds the catalytic subunit of protein phosphatase 1 (PP1C) and localizes it to glycogen. Subsets of similar interactions have been observed with several other members of this family, such as the yeast PIG1, PIG2, GAC1 and GIP2 proteins. While the precise function of these proteins is not known, they may serve a scaffold function, bringing together the key enzymes in glycogen metabolizm. This family is a carbohydrate binding domain.","GO:0005979|regulation of glycogen biosynthetic process;GO:0042593|glucose homeostasis;GO:0045725|positive regulation of glycogen biosynthetic process;GO:2000467|positive regulation of glycogen (starch) synthase activity;","GO:0000164|protein phosphatase type 1 complex;GO:0005737|cytoplasm;","GO:0008157|protein phosphatase 1 binding;GO:0019903|protein phosphatase binding;GO:2001069|glycogen binding;",".","."]
["ENSRNOG00000007189",143,9.19925266,47,3.034407404,3.031647184,1.600101866,{"v":1.23879E-12,"d":"1.24E-12"},{"v":1.48855E-12,"d":"1.49E-12"},"up","yes","Ttc22","protein_coding","chr5:121406326-121423130:+","gi|157821039|ref|NP_001100141.1|",2853,0,"tetratricopeptide repeat protein 22 [Rattus norvegicus]","gi|157821038|ref|NM_001106671.1|",2553,0,"Rattus norvegicus tetratricopeptide repeat domain 22 (Ttc22), mRNA",".",".",".",".",".",".",".",".","pfam13414","TPR_11","TPR repeat.",".",".",".","K24933","TTC22; tetratricopeptide repeat protein 22"]
["ENSRNOG00000065095",249,16.01827911,115,7.42461386,2.157456187,1.109331262,{"v":1.51707e-12,"d":"1.52E-12"},{"v":1.81341E-12,"d":"1.81E-12"},"up","yes","ENSRNOG00000065095","protein_coding","chr18:60282810-60284019:-","gi|852773041|ref|XP_012879948.1|",549,{"v":5e-66,"d":"5.00E-66"},"PREDICTED: cytochrome c, somatic [Dipodomys ordii]","gi|203718|gb|K03238.1|RATCYCP09",1210,0,"Rat (Sprague-Dawley) cytochrome c pseudogene, clone Ch4A-RC9","P62898",216,{"v":2e-67,"d":"2.00E-67"},"Cytochrome c, somatic","SPCC191.07",160,{"v":1E-46,"d":"1.00E-46"},"COG3474","pfam00034","Cytochrom_C","Cytochrome c. The Pfam entry does not include all Prosite members. The cytochrome 556 and cytochrome c' families are not included. All these are now in a new clan together. The C-terminus of DUF989, pfam06181, has now been merged into this family.",".",".",".",".","."]
["ENSRNOG00000010853",70,4.503130673,10,0.645618597,6.974908556,2.802174303,{"v":1.61206e-12,"d":"1.61E-12"},{"v":1.92333E-12,"d":"1.92E-12"},"up","yes","Chrna7","protein_coding","chr1:116714711-116837240:-","gi|144922602|ref|NP_036964.3|",2475,0,"neuronal acetylcholine receptor subunit alpha-7 precursor [Rattus norvegicus]","gi|3478618|gb|L31619.1|RATNARAD",2080,0,"Rattus rattus nicotinic acetylcholine receptor alpha 7 subunit mRNA, complete cds","Q05941",954,0,"Neuronal acetylcholine receptor subunit alpha-7",".",".",".",".","pfam02931","Neur_chan_LBD","Neurotransmitter-gated ion-channel ligand binding domain. This family is the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.","GO:0001666|response to hypoxia;GO:0001933|negative regulation of protein phosphorylation;GO:0001934|positive regulation of protein phosphorylation;GO:0001988|positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure;GO:0006811|ion transport;GO:0006816|calcium ion transport;GO:0006874|cellular calcium ion homeostasis;GO:0006897|endocytosis;GO:0007165|signal transduction;GO:0007268|chemical synaptic transmission;GO:0007271|synaptic transmission, cholinergic;GO:0007611|learning or memory;GO:0007613|memory;GO:0008284|positive regulation of cell proliferation;GO:0008306|associative learning;GO:0009409|response to cold;GO:0014061|regulation of norepinephrine secretion;GO:0019228|neuronal action potential;GO:0030317|flagellated sperm motility;GO:0032094|response to food;GO:0032225|regulation of synaptic transmission, dopaminergic;GO:0032691|negative regulation of interleukin-1 beta production;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0034220|ion transmembrane transport;GO:0035094|response to nicotine;GO:0035095|behavioral response to nicotine;GO:0042110|T cell activation;GO:0042113|B cell activation;GO:0042391|regulation of membrane potential;GO:0042416|dopamine biosynthetic process;GO:0042698|ovulation cycle;GO:0043410|positive regulation of MAPK cascade;GO:0045471|response to ethanol;GO:0045766|positive regulation of angiogenesis;GO:0048149|behavioral response to ethanol;GO:0050727|regulation of inflammatory response;GO:0050728|negative regulation of inflammatory response;GO:0050804|modulation of chemical synaptic transmission;GO:0050808|synapse organization;GO:0050877|nervous system process;GO:0050890|cognition;GO:0050893|sensory processing;GO:0051247|positive regulation of protein metabolic process;GO:0060079|excitatory postsynaptic potential;GO:0060112|generation of ovulation cycle rhythm;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0095500|acetylcholine receptor signaling pathway;GO:0097061|dendritic spine organization;GO:0098815|modulation of excitatory postsynaptic potential;GO:0140059|dendrite arborization;GO:1900273|positive regulation of long-term synaptic potentiation;GO:1901214|regulation of neuron death;GO:1902004|positive regulation of amyloid-beta formation;GO:1902430|negative regulation of amyloid-beta formation;GO:1902991|regulation of amyloid precursor protein catabolic process;GO:1904645|response to amyloid-beta;GO:1905144|response to acetylcholine;GO:1905906|regulation of amyloid fibril formation;GO:1905920|positive regulation of CoA-transferase activity;GO:2000300|regulation of synaptic vesicle exocytosis;GO:2000463|positive regulation of excitatory postsynaptic potential;GO:2001023|regulation of response to drug;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005892|acetylcholine-gated channel complex;GO:0009897|external side of plasma membrane;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0030426|growth cone;GO:0030673|axolemma;GO:0032279|asymmetric synapse;GO:0042734|presynaptic membrane;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043197|dendritic spine;GO:0043198|dendritic shaft;GO:0044853|plasma membrane raft;GO:0045121|membrane raft;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0098690|glycinergic synapse;GO:0098981|cholinergic synapse;GO:0099055|integral component of postsynaptic membrane;GO:0099056|integral component of presynaptic membrane;GO:0099060|integral component of postsynaptic specialization membrane;GO:0099065|integral component of spine apparatus membrane;","GO:0001540|amyloid-beta binding;GO:0004888|transmembrane signaling receptor activity;GO:0005216|ion channel activity;GO:0005515|protein binding;GO:0008179|adenylate cyclase binding;GO:0015464|acetylcholine receptor activity;GO:0015643|toxic substance binding;GO:0017081|chloride channel regulator activity;GO:0019901|protein kinase binding;GO:0022848|acetylcholine-gated cation-selective channel activity;GO:0030594|neurotransmitter receptor activity;GO:0042166|acetylcholine binding;GO:0042803|protein homodimerization activity;GO:0051117|ATPase binding;GO:0097110|scaffold protein binding;GO:1904315|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K04809","CHRNA7; nicotinic acetylcholine receptor alpha-7"]
["ENSRNOG00000054935",121,7.78398302,35,2.259665088,3.444750756,1.784399601,{"v":1.72194E-12,"d":"1.72E-12"},{"v":2.04929E-12,"d":"2.05E-12"},"up","yes","AC119007.4","lncRNA","chr7:132408978-132413672:+","gi|149031988|gb|EDL86900.1|",392,{"v":2E-41,"d":"2.00E-41"},"rCG50756, partial [Rattus norvegicus]","gi|672022400|ref|XR_602000.1|",1987,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103692985 (LOC103692985), ncRNA",".",".",".",".",".",".",".",".","pfam15091","DUF4554","Domain of unknown function (DUF4554). This family of proteins is functionally uncharacterized. This family of proteins is found in some vertebrates. This family includes human protein C11orf80.",".",".",".",".","."]
["ENSRNOG00000070702",106,6.819026448,27,1.743170211,3.911853476,1.967852333,{"v":1.73117E-12,"d":"1.73E-12"},{"v":2.05862E-12,"d":"2.06E-12"},"up","yes","Smkr1","protein_coding","chr4:58601660-58609229:+","gi|672018241|ref|XP_008773937.1|",383,{"v":1E-41,"d":"1.00E-41"},"PREDICTED: small lysine-rich protein 1 isoform X1 [Rattus norvegicus]","gi|672018240|ref|XM_008775715.1|",712,0,"PREDICTED: Rattus norvegicus small lysine-rich protein 1 (Smkr1), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam07845","DUF1636","Protein of unknown function (DUF1636). The sequences featured in this family are derived from a number of hypothetical prokaryotic proteins. The region in question is approximately 130 amino acids long.",".",".",".",".","."]
["ENSRNOG00000013719",247,15.88961823,114,7.360052001,2.158900267,1.110296598,{"v":1.79681e-12,"d":"1.80E-12"},{"v":2.13617e-12,"d":"2.14E-12"},"up","yes","Dph5","protein_coding","chr2:203804936-203840433:+","gi|672043983|ref|XP_008759676.1|",1722,0,"PREDICTED: diphthine synthase isoform X2 [Rattus norvegicus]","gi|672043982|ref|XM_008761454.1|",1361,0,"PREDICTED: Rattus norvegicus diphthamide biosynthesis 5 (Dph5), transcript variant X1, mRNA","Q9CWQ0",575,0,"Diphthine methyl ester synthase","SPCC576.14",345,{"v":5e-109,"d":"5.00E-109"},"COG1798","pfam00590","TP_methylase","Tetrapyrrole (Corrin/Porphyrin) Methylases. This family uses S-AdoMet in the methylation of diverse substrates. This family includes a related group of bacterial proteins of unknown function. This family includes the methylase Dipthine synthase.","GO:0008150|biological_process;GO:0017183|peptidyl-diphthamide biosynthetic process from peptidyl-histidine;GO:0032259|methylation;","GO:0005575|cellular_component;","GO:0003674|molecular_function;GO:0004164|diphthine synthase activity;","K00586","DPH5; diphthine methyl ester synthase [EC:2.1.1.314]"]
["ENSRNOG00000064983",46,2.959200157,1,0.06456186,45.83511337,5.518381337,{"v":1.86956E-12,"d":"1.87E-12"},{"v":2.22174e-12,"d":"2.22E-12"},"up","yes","ENSRNOG00000064983","processed_pseudogene","chr1:64480247-64481182:+","gi|568906221|ref|XP_006495974.1|",1628,0,"PREDICTED: eukaryotic translation initiation factor 5B isoform X1 [Mus musculus]","gi|225637554|ref|NG_006708.1|",936,0,"Rattus norvegicus vomeronasal 2 receptor, pseudogene 40 (Vom2r-ps40) on chromosome 14","Q05D44",624,0,"Eukaryotic translation initiation factor 5B","SPAC56F8.03",277,{"v":9e-84,"d":"9.00E-84"},"COG0532","pfam11987","IF-2","Translation-initiation factor 2. IF-2 is a translation initiator in each of the three main phylogenetic domains (Eukaryotes, Bacteria and Archaea). IF2 interacts with formylmethionine-tRNA, GTP, IF1, IF3 and both ribosomal subunits. Through these interactions, IF2 promotes the binding of the initiator tRNA to the A site in the smaller ribosomal subunit and catalyses the hydrolysis of GTP following initiation-complex formation.",".",".",".",".","."]
["ENSRNOG00000013496",51,3.280852347,3,0.193685579,16.93906364,4.082282222,{"v":1.96438e-12,"d":"1.96E-12"},{"v":2.33248e-12,"d":"2.33E-12"},"up","yes","Crisp3","protein_coding","chr9:20450908-20472658:+","gi|12408314|ref|NP_074050.1|",1130,{"v":2e-153,"d":"2.00E-153"},"cysteine-rich secretory protein 1 precursor [Rattus norvegicus]","gi|56112|emb|X04643.1|",864,0,"Rat mRNA for epididymal secretory glycoproteins","P12020",439,{"v":7e-155,"d":"7.00E-155"},"Cysteine-rich secretory protein 1",".",".",".",".","pfam08562","Crisp","Crisp. This domain is found on Crisp proteins which contain pfam00188 and has been termed the Crisp domain. It is found in the mammalian reproductive tract and the venom of reptiles, and has been shown to regulate ryanodine receptor Ca2+ signalling. It contains 10 conserved cysteines which are all involved in disulphide bonds and is structurally related to the ion channel inhibitor toxins BgK and ShK.",".","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0042581|specific granule;",".",".","."]
["ENSRNOG00000029055",247,15.88961823,115,7.42461386,2.140127221,1.097696561,{"v":2.85583E-12,"d":"2.86E-12"},{"v":3.36994e-12,"d":"3.37E-12"},"up","yes","Ttk","protein_coding","chr8:84754315-84792651:+","gi|564364700|ref|XP_006243523.1|",4529,0,"PREDICTED: dual specificity protein kinase TTK isoform X2 [Rattus norvegicus]","gi|672062099|ref|XM_006243461.2|",3052,0,"PREDICTED: Rattus norvegicus Ttk protein kinase (Ttk), transcript variant X2, mRNA","P35761",1438,0,"Dual specificity protein kinase TTK",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0007059|chromosome segregation;GO:0007094|mitotic spindle assembly checkpoint;GO:0016321|female meiosis chromosome segregation;GO:0018105|peptidyl-serine phosphorylation;GO:0018107|peptidyl-threonine phosphorylation;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0033316|meiotic spindle assembly checkpoint;GO:0034501|protein localization to kinetochore;GO:0034502|protein localization to chromosome;GO:0046777|protein autophosphorylation;GO:0051304|chromosome separation;GO:1903096|protein localization to meiotic spindle midzone;","GO:0000776|kinetochore;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005819|spindle;","GO:0004674|protein serine/threonine kinase activity;GO:0004712|protein serine/threonine/tyrosine kinase activity;GO:0005524|ATP binding;GO:0042802|identical protein binding;GO:0043515|kinetochore binding;","K08866","TTK, MPS1; serine/threonine-protein kinase TTK/MPS1 [EC:2.7.12.1]"]
["ENSRNOG00000042308",202,12.99474851,85,5.487758071,2.367952148,1.243639927,{"v":3.00478E-12,"d":"3.00E-12"},{"v":3.54058e-12,"d":"3.54E-12"},"up","yes","ENSRNOG00000042308","protein_coding","chr1:34927303-34944121:-","gi|213385283|ref|NP_001132963.1|",2508,0,"zinc finger protein 455-like [Rattus norvegicus]","gi|213385282|ref|NM_001139491.1|",1529,0,"Rattus norvegicus similar to zinc finger protein 455 (LOC680200), mRNA","P16372",491,{"v":2E-167,"d":"2.00E-167"},"Zinc finger protein 58",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006357|regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0046872|metal ion binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSRNOG00000042658",78,5.017774178,14,0.903866035,5.55145783,2.472866677,{"v":3.22966e-12,"d":"3.23E-12"},{"v":3.80086e-12,"d":"3.80E-12"},"up","yes","Nxnl1","protein_coding","chr16:18262688-18279987:-","gi|404501522|ref|NP_001258270.1|",1085,{"v":3e-142,"d":"3.00E-142"},"nucleoredoxin-like protein 1 [Rattus norvegicus]","gi|672079662|ref|XM_006252894.2|",1212,0,"PREDICTED: Rattus norvegicus nucleoredoxin-like 1 (Nxnl1), transcript variant X3, mRNA","Q8VC33",395,{"v":6e-133,"d":"6.00E-133"},"Nucleoredoxin-like protein 1",".",".",".",".","pfam13905","Thioredoxin_8","Thioredoxin-like. Thioredoxins are small enzymes that participate in redox reactions, via the reversible oxidation of an active centre disulfide bond.","GO:0045494|photoreceptor cell maintenance;",".",".",".","."]
["ENSRNOG00000071128",167,10.74318318,63,4.067397158,2.641291902,1.40124375,{"v":3.50842e-12,"d":"3.51E-12"},{"v":4.11958e-12,"d":"4.12E-12"},"up","yes","B3gnt4","protein_coding","chr12:33060416-33073854:-","gi|157786938|ref|NP_001099408.1|",1738,0,"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 precursor [Rattus norvegicus]","gi|672072940|ref|XM_006249335.2|",1956,0,"PREDICTED: Rattus norvegicus UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 (B3gnt4), transcript variant X1, mRNA","Q1RLK6",644,0,"N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4",".",".",".",".","pfam01762","Galactosyl_T","Galactosyltransferase. This family includes the galactosyltransferases UDP-galactose:2-acetamido-2-deoxy-D-glucose3beta-galactosyltransferase and UDP-Gal:beta-GlcNAc beta 1,3-galactosyltranferase. Specific galactosyltransferases transfer galactose to GlcNAc terminal chains in the synthesis of the lacto-series oligosaccharides types 1 and 2.",".",".",".",".","."]
["ENSRNOG00000001711",179,11.51514844,71,4.583892036,2.512089802,1.328888038,{"v":4.65952e-12,"d":"4.66E-12"},{"v":5.44101e-12,"d":"5.44E-12"},"up","yes","Plaat1","protein_coding","chr11:71517493-71527020:-","gi|157786776|ref|NP_001099341.1|",814,{"v":4e-99,"d":"4.00E-99"},"phospholipid-metabolizing enzyme A-C1 [Rattus norvegicus]","gi|672071388|ref|XM_006248510.2|",2826,0,"PREDICTED: Rattus norvegicus HRAS-like suppressor (Hrasls), transcript variant X1, mRNA","Q9QZU4",303,{"v":6e-95,"d":"6.00E-95"},"Phospholipid-metabolizing enzyme A-C1",".",".",".",".","pfam04970","LRAT","Lecithin retinol acyltransferase. The full-length members of this family are representatives of a novel class II tumor-suppressor family, designated as H-REV107-like. This domain is the catalytic N-terminal proline-rich region of the protein. The downstream region is a putative C-terminal transmembrane domain which is found to be crucial for cellular localisation, but not necessary for the enzyme activity. H-REV107-like proteins are homologous to lecithin retinol acyltransferase (LRAT), an enzyme that catalyses the transfer of the sn-1 acyl group of phosphatidylcholine to all-trans-retinol and forming a retinyl ester.","GO:0007031|peroxisome organization;GO:0016042|lipid catabolic process;GO:0046470|phosphatidylcholine metabolic process;GO:0046485|ether lipid metabolic process;GO:0070292|N-acylphosphatidylethanolamine metabolic process;GO:0070306|lens fiber cell differentiation;GO:1903008|organelle disassembly;","GO:0005634|nucleus;GO:0005641|nuclear envelope lumen;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005764|lysosome;GO:0005777|peroxisome;GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;GO:0016021|integral component of membrane;","GO:0004620|phospholipase activity;GO:0004623|phospholipase A2 activity;GO:0008374|O-acyltransferase activity;GO:0008970|phospholipase A1 activity;GO:0016410|N-acyltransferase activity;GO:0052739|phosphatidylserine 1-acylhydrolase activity;GO:0052740|1-acyl-2-lysophosphatidylserine acylhydrolase activity;",".","."]
["ENSRNOG00000065348",75,4.824782864,13,0.839304176,5.748551008,2.523198353,{"v":4.82714e-12,"d":"4.83E-12"},{"v":5.63329e-12,"d":"5.63E-12"},"up","yes","Pax9","protein_coding","chr6:74182568-74203506:+","gi|88014534|ref|NP_001034628.1|",1732,0,"paired box protein Pax-9 [Rattus norvegicus]","gi|88014533|ref|NM_001039539.1|",3743,0,"Rattus norvegicus paired box 9 (Pax9), mRNA","Q2L4T2",668,0,"Paired box protein Pax-9",".",".",".",".","pfam00292","PAX","'Paired box' domain.",".",".",".",".","."]
["ENSRNOG00000015275",177,11.38648756,70,4.519330176,2.519507784,1.333141914,{"v":5.43341E-12,"d":"5.43E-12"},{"v":6.32658e-12,"d":"6.33E-12"},"up","yes","Ska1","protein_coding","chr18:67794725-67805037:-","gi|157817406|ref|NP_001099604.1|",1160,{"v":1e-154,"d":"1.00E-154"},"spindle and kinetochore-associated protein 1 [Rattus norvegicus]","gi|157817405|ref|NM_001106134.1|",1440,0,"Rattus norvegicus spindle and kinetochore associated complex subunit 1 (Ska1), mRNA","B0BN28",451,{"v":3e-156,"d":"3.00E-156"},"Spindle and kinetochore-associated protein 1",".",".",".",".","pfam07160","DUF1395","Protein of unknown function (DUF1395). This family consists of several hypothetical eukaryotic proteins of around 250 residues in length. The function of this family is unknown.","GO:0000278|mitotic cell cycle;GO:0007059|chromosome segregation;GO:0031110|regulation of microtubule polymerization or depolymerization;GO:0051301|cell division;","GO:0000940|condensed chromosome outer kinetochore;GO:0005737|cytoplasm;GO:0005876|spindle microtubule;GO:0015630|microtubule cytoskeleton;GO:0072686|mitotic spindle;","GO:0008017|microtubule binding;",".","."]
["ENSRNOG00000029427",81,5.210765493,16,1.032989754,5.044353509,2.334669384,{"v":6.6143e-12,"d":"6.61E-12"},{"v":7.65633e-12,"d":"7.66E-12"},"up","yes","Grhl3","protein_coding","chr5:147774160-147806160:-","gi|672054381|ref|XP_008762438.1|",3152,0,"PREDICTED: grainyhead-like protein 3 homolog isoform X1 [Rattus norvegicus]","gi|672054380|ref|XM_008764216.1|",2641,0,"PREDICTED: Rattus norvegicus grainyhead-like 3 (Drosophila) (Grhl3), transcript variant X1, mRNA","Q5FWH3",1180,0,"Grainyhead-like protein 3 homolog",".",".",".",".","pfam04516","CP2","CP2 transcription factor. This family represents a conserved region in the CP2 transcription factor family.","GO:0001736|establishment of planar polarity;GO:0001843|neural tube closure;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007389|pattern specification process;GO:0007398|ectoderm development;GO:0007417|central nervous system development;GO:0008544|epidermis development;GO:0010628|positive regulation of gene expression;GO:0032956|regulation of actin cytoskeleton organization;GO:0042060|wound healing;GO:0043547|positive regulation of GTPase activity;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0061029|eyelid development in camera-type eye;GO:0061436|establishment of skin barrier;GO:0090103|cochlea morphogenesis;GO:0090179|planar cell polarity pathway involved in neural tube closure;","GO:0005634|nucleus;GO:0005654|nucleoplasm;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0031490|chromatin DNA binding;GO:0043565|sequence-specific DNA binding;","K09275","TFCP2; transcription factor CP2 and related proteins"]
["ENSRNOG00000067139",224,14.41001815,102,6.585309685,2.188206606,1.129748961,{"v":9.9101e-12,"d":"9.91E-12"},{"v":1.13837E-11,"d":"1.14E-11"},"up","yes","Rpl10l","protein_coding","chr6:84543540-84545816:-","gi|946668211|ref|XP_014419151.1|",1145,{"v":5e-149,"d":"5.00E-149"},"PREDICTED: 60S ribosomal protein L10 isoform X1 [Camelus ferus]","gi|22296791|gb|AC125344.2|",1308,0,"Mus musculus BAC clone RP24-332H21 from 12, complete sequence","P86048",443,{"v":7e-150,"d":"7.00E-150"},"60S ribosomal protein L10-like","SPAP7G5.05",315,{"v":1E-100,"d":"1.00E-100"},"COG0197","pfam00252","Ribosomal_L16","Ribosomal protein L16p/L10e.",".",".",".",".","."]
["ENSRNOG00000024456",164,10.55019186,63,4.067397158,2.593843545,1.375091462,{"v":1.08307E-11,"d":"1.08E-11"},{"v":1.24112E-11,"d":"1.24E-11"},"up","yes","Radil","protein_coding","chr12:12024395-12088540:+","gi|149034989|gb|EDL89709.1|",5256,0,"rCG42648, isoform CRA_b [Rattus norvegicus]","gi|575771879|ref|NM_001289588.1|",2951,0,"Mus musculus Ras association and DIL domains (Radil), transcript variant 1, mRNA","Q69Z89",1917,0,"Ras-associating and dilute domain-containing protein",".",".",".",".","pfam01843","DIL","DIL domain. The DIL domain has no known function.","GO:0001755|neural crest cell migration;GO:0007165|signal transduction;GO:0034446|substrate adhesion-dependent cell spreading;","GO:0005874|microtubule;GO:0032991|protein-containing complex;","GO:0051020|GTPase binding;",".","."]
["ENSRNOG00000022537",151,9.713896166,55,3.550902281,2.735613486,1.451864406,{"v":1.09689E-11,"d":"1.10E-11"},{"v":1.25646e-11,"d":"1.26E-11"},"up","yes","E2f8","protein_coding","chr1:98565717-98584098:-","gi|109462000|ref|XP_001080259.1|",4545,0,"PREDICTED: transcription factor E2F8 isoform X1 [Rattus norvegicus]","gi|672013602|ref|XM_001080259.5|",5122,0,"PREDICTED: Rattus norvegicus E2F transcription factor 8 (E2f8), transcript variant X1, mRNA","F1LMN3",1680,0,"Transcription factor E2F8",".",".",".",".","pfam02319","E2F_TDP","E2F/DP family winged-helix DNA-binding domain. This family contains the transcription factor E2F and its dimerization partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001890|placenta development;GO:0002040|sprouting angiogenesis;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008283|cell proliferation;GO:0032466|negative regulation of cytokinesis;GO:0032877|positive regulation of DNA endoreduplication;GO:0033301|cell cycle comprising mitosis without cytokinesis;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0060707|trophoblast giant cell differentiation;GO:0060718|chorionic trophoblast cell differentiation;GO:0070365|hepatocyte differentiation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005730|nucleolus;GO:0005829|cytosol;GO:0090575|RNA polymerase II transcription factor complex;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987|proximal promoter sequence-specific DNA binding;GO:0001217|bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0042802|identical protein binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09391","E2F7_8; transcription factor E2F7/8"]
["ENSRNOG00000003620",80,5.146435055,16,1.032989754,4.98207754,2.316747476,{"v":1.10652E-11,"d":"1.11E-11"},{"v":1.26723E-11,"d":"1.27E-11"},"up","yes","Fmo3","protein_coding","chr13:75309374-75328028:-","gi|148539991|ref|NP_445885.2|",2702,0,"dimethylaniline monooxygenase [N-oxide-forming] 3 [Rattus norvegicus]","gi|672074545|ref|XR_595502.1|",2034,0,"PREDICTED: Rattus norvegicus flavin containing monooxygenase 3 (Fmo3), transcript variant X1, misc_RNA","Q9EQ76",1041,0,"Dimethylaniline monooxygenase [N-oxide-forming] 3","CC0774",191,{"v":3E-52,"d":"3.00E-52"},"COG2072","pfam00743","FMO-like","Flavin-binding monooxygenase-like. This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.","GO:0006805|xenobiotic metabolic process;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0004497|monooxygenase activity;GO:0004499|N,N-dimethylaniline monooxygenase activity;GO:0016597|amino acid binding;GO:0034899|trimethylamine monooxygenase activity;GO:0050660|flavin adenine dinucleotide binding;GO:0050661|NADP binding;","K00485","FMO; dimethylaniline monooxygenase (N-oxide forming) / hypotaurine monooxygenase [EC:1.14.13.8 1.8.1.-]"]
["ENSRNOG00000048472",102,6.561704695,27,1.743170211,3.764236363,1.91235722,{"v":1.12112e-11,"d":"1.12E-11"},{"v":1.28292e-11,"d":"1.28E-11"},"up","yes","Comp","protein_coding","chr16:19047207-19055845:-","gi|6978679|ref|NP_036966.1|",2749,0,"cartilage oligomeric matrix protein precursor [Rattus norvegicus]","gi|672079513|ref|XM_006252822.2|",2022,0,"PREDICTED: Rattus norvegicus cartilage oligomeric matrix protein (Comp), transcript variant X1, mRNA","P35444",1063,0,"Cartilage oligomeric matrix protein",".",".",".",".","pfam05735","TSP_C","Thrombospondin C-terminal region. This region is found at the C-terminus of thrombospondin and related proteins.","GO:0001501|skeletal system development;GO:0001503|ossification;GO:0002063|chondrocyte development;GO:0003416|endochondral bone growth;GO:0003417|growth plate cartilage development;GO:0006915|apoptotic process;GO:0006986|response to unfolded protein;GO:0007155|cell adhesion;GO:0007596|blood coagulation;GO:0009306|protein secretion;GO:0010259|multicellular organism aging;GO:0010260|animal organ senescence;GO:0010468|regulation of gene expression;GO:0014829|vascular smooth muscle contraction;GO:0016485|protein processing;GO:0030199|collagen fibril organization;GO:0030282|bone mineralization;GO:0030500|regulation of bone mineralization;GO:0030509|BMP signaling pathway;GO:0035264|multicellular organism growth;GO:0035988|chondrocyte proliferation;GO:0035989|tendon development;GO:0043066|negative regulation of apoptotic process;GO:0043588|skin development;GO:0048844|artery morphogenesis;GO:0050881|musculoskeletal movement;GO:0050905|neuromuscular process;GO:0051216|cartilage development;GO:0055001|muscle cell development;GO:0060173|limb development;GO:0060349|bone morphogenesis;GO:0070527|platelet aggregation;GO:0097084|vascular smooth muscle cell development;GO:0098868|bone growth;GO:1900047|negative regulation of hemostasis;GO:1902732|positive regulation of chondrocyte proliferation;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0032991|protein-containing complex;GO:0062023|collagen-containing extracellular matrix;","GO:0001968|fibronectin binding;GO:0002020|protease binding;GO:0005178|integrin binding;GO:0005201|extracellular matrix structural constituent;GO:0005499|vitamin D binding;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0005518|collagen binding;GO:0008201|heparin binding;GO:0036122|BMP binding;GO:0043394|proteoglycan binding;GO:0043395|heparan sulfate proteoglycan binding;","K04659","THBS2S; thrombospondin 2/3/4/5"]
["ENSRNOG00000019447",64,4.117148044,9,0.581056737,7.08562139,2.824894379,{"v":1.17742E-11,"d":"1.18E-11"},{"v":1.34519e-11,"d":"1.35E-11"},"up","yes","Ecel1","protein_coding","chr9:87816718-87826675:-","gi|148708241|gb|EDL40188.1|",3882,0,"endothelin converting enzyme-like 1, isoform CRA_a, partial [Mus musculus]","gi|564369656|ref|XM_006245475.1|",3289,0,"PREDICTED: Rattus norvegicus endothelin converting enzyme-like 1 (Ecel1), transcript variant X1, mRNA","Q9JHL3",1484,0,"Endothelin-converting enzyme-like 1","MA2001",329,{"v":1e-95,"d":"1.00E-95"},"COG3590","pfam05649","Peptidase_M13_N","Peptidase family M13. M13 peptidases are well-studied proteases found in a wide range of organisms including mammals and bacteria. In mammals they participate in processes such as cardiovascular development, blood-pressure regulation, nervous control of respiration, and regulation of the function of neuropeptides in the central nervous system. In bacteria they may be used for digestion of milk.","GO:0003016|respiratory system process;GO:0006508|proteolysis;GO:0007218|neuropeptide signaling pathway;GO:0016485|protein processing;GO:0035556|intracellular signal transduction;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004222|metalloendopeptidase activity;GO:0046872|metal ion binding;","K09610","ECEL1; endothelin-converting enzyme-like 1 [EC:3.4.24.-]"]
["ENSRNOG00000039856",116,7.462330829,35,2.259665088,3.302405684,1.723517359,{"v":1.55054e-11,"d":"1.55E-11"},{"v":1.76091e-11,"d":"1.76E-11"},"up","yes","Lrrc73","protein_coding","chr9:14726158-14729158:-","gi|66730525|ref|NP_001019531.1|",1419,0,"leucine-rich repeat-containing protein 73 [Rattus norvegicus]","gi|119310198|ref|NM_001024360.2|",1298,0,"Rattus norvegicus leucine rich repeat containing 73 (Lrrc73), mRNA",".",".",".",".",".",".",".",".","pfam15143","DUF4575","Domain of unknown function (DUF4575). This family of uncharacterized proteins is found in eukaryotes.",".",".",".",".","."]
["ENSRNOG00000065255",101,6.497374257,27,1.743170211,3.727332085,1.898143361,{"v":1.78045e-11,"d":"1.78E-11"},{"v":2.0144E-11,"d":"2.01E-11"},"up","yes","Gsg1l","protein_coding","chr1:180442630-180654134:-","gi|442580958|sp|D3ZK93.1|GSG1L_RAT",1442,0,"RecName: Full=Germ cell-specific gene 1-like protein; Short=GSG1-like protein","gi|672038614|ref|XM_008759923.1|",1402,0,"PREDICTED: Rattus norvegicus GSG1-like (Gsg1l), transcript variant X2, mRNA","D3ZK93",560,0,"Germ cell-specific gene 1-like protein",".",".",".",".","pfam07803","GSG-1","GSG1-like protein. This family contains sequences bearing similarity to a region of GSG1, a protein specifically expressed in testicular germ cells. It is possible that overexpression of the human homolog may be involved in tumorigenesis of human testicular germ cell tumors. The region in question has four highly-conserved cysteine residues.",".",".",".",".","."]
["ENSRNOG00000002754",44,2.83053928,2,0.129123719,21.92114118,4.454250999,{"v":2.28392e-11,"d":"2.28E-11"},{"v":2.57383e-11,"d":"2.57E-11"},"up","yes","Areg","protein_coding","chr14:16972187-16981535:-","gi|8392917|ref|NP_058819.1|",719,{"v":2e-89,"d":"2.00E-89"},"amphiregulin preproprotein [Rattus norvegicus]","gi|8392916|ref|NM_017123.1|",1122,0,"Rattus norvegicus amphiregulin (Areg), mRNA","P24338",281,{"v":7e-91,"d":"7.00E-91"},"Amphiregulin",".",".",".",".","pfam05541","Spheroidin","Entomopoxvirus spheroidin protein. Entomopoxviruses (EPVs) are large (300-400 nm) oval-shaped viruses replicating in the cytoplasm of their insect host cells. At the end of their replicative cycle EPVs virions are occluded in a highly expressed protein called spheroidin. This protein forms large (5-20 mm long) oval-shaped occlusion bodies (OBs) called spherules. The infectious cycle of EPVs begins with the ingestion by the insect host of the spherules, their dissolution by the alkaline reducing conditions of the midgut fluid and the release of virions in the midgut lumen. The infective particles first replicate in midgut epithelial cells, then pass the gut barrier to colonise the internal tissues, mainly the fat body cells. Whilst spheroidin has been demonstrated to be non-essential for viral replication, it plays an essential role in the natural biological cycle of the virus in protecting virions from adverse environmental conditions (e.g. UV degradation) and thus improving transmission efficacy. In this respect, spheroidins are functionally similar to polyhedrins of baculoviruses or cypoviruses.","GO:0007173|epidermal growth factor receptor signaling pathway;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007417|central nervous system development;GO:0008284|positive regulation of cell proliferation;GO:0014009|glial cell proliferation;GO:0014070|response to organic cyclic compound;GO:0031175|neuron projection development;GO:0032355|response to estradiol;GO:0042327|positive regulation of phosphorylation;GO:0042542|response to hydrogen peroxide;GO:0043434|response to peptide hormone;GO:0045668|negative regulation of osteoblast differentiation;GO:0045741|positive regulation of epidermal growth factor-activated receptor activity;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0051384|response to glucocorticoid;GO:0051591|response to cAMP;GO:0060598|dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis;GO:0060744|mammary gland branching involved in thelarche;GO:0060749|mammary gland alveolus development;GO:0060750|epithelial cell proliferation involved in mammary gland duct elongation;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0005125|cytokine activity;GO:0005154|epidermal growth factor receptor binding;GO:0008083|growth factor activity;","K09782","AREG; amphiregulin"]
["ENSRNOG00000020701",218,14.02403552,100,6.456185966,2.172185807,1.119147516,{"v":2.64273e-11,"d":"2.64E-11"},{"v":2.96765e-11,"d":"2.97E-11"},"up","yes","Brca1","protein_coding","chr10:86418000-86477304:-","gi|672068852|ref|XP_008766314.1|",9060,0,"PREDICTED: breast cancer type 1 susceptibility protein homolog isoform X1 [Rattus norvegicus]","gi|672068851|ref|XM_008768092.1|",5419,0,"PREDICTED: Rattus norvegicus breast cancer 1, early onset (Brca1), transcript variant X1, mRNA","O54952",3447,0,"Breast cancer type 1 susceptibility protein homolog",".",".",".",".","pfam04873","EIN3","Ethylene insensitive 3. Ethylene insensitive 3 (EIN3) proteins are a family of plant DNA-binding proteins that regulate transcription in response to the gaseous plant hormone ethylene, and are essential for ethylene-mediated responses including the triple response, cell growth inhibition, and accelerated senescence.","GO:0000724|double-strand break repair via homologous recombination;GO:0006301|postreplication repair;GO:0006302|double-strand break repair;GO:0006349|regulation of gene expression by genetic imprinting;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006633|fatty acid biosynthetic process;GO:0006974|cellular response to DNA damage stimulus;GO:0007059|chromosome segregation;GO:0007095|mitotic G2 DNA damage checkpoint;GO:0007098|centrosome cycle;GO:0007420|brain development;GO:0007584|response to nutrient;GO:0008630|intrinsic apoptotic signaling pathway in response to DNA damage;GO:0009048|dosage compensation by inactivation of X chromosome;GO:0010033|response to organic substance;GO:0010212|response to ionizing radiation;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0010628|positive regulation of gene expression;GO:0016567|protein ubiquitination;GO:0031398|positive regulation of protein ubiquitination;GO:0032355|response to estradiol;GO:0033147|negative regulation of intracellular estrogen receptor signaling pathway;GO:0033993|response to lipid;GO:0035066|positive regulation of histone acetylation;GO:0035067|negative regulation of histone acetylation;GO:0042307|positive regulation of protein import into nucleus;GO:0043009|chordate embryonic development;GO:0043627|response to estrogen;GO:0044030|regulation of DNA methylation;GO:0044818|mitotic G2/M transition checkpoint;GO:0045717|negative regulation of fatty acid biosynthetic process;GO:0045739|positive regulation of DNA repair;GO:0045766|positive regulation of angiogenesis;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051571|positive regulation of histone H3-K4 methylation;GO:0051572|negative regulation of histone H3-K4 methylation;GO:0051573|negative regulation of histone H3-K9 methylation;GO:0051574|positive regulation of histone H3-K9 methylation;GO:0051726|regulation of cell cycle;GO:0051865|protein autoubiquitination;GO:0070512|positive regulation of histone H4-K20 methylation;GO:0071356|cellular response to tumor necrosis factor;GO:0071681|cellular response to indole-3-methanol;GO:0085020|protein K6-linked ubiquitination;GO:1902042|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:2000378|negative regulation of reactive oxygen species metabolic process;GO:2000617|positive regulation of histone H3-K9 acetylation;GO:2000620|positive regulation of histone H4-K16 acetylation;","GO:0000793|condensed chromosome;GO:0000794|condensed nuclear chromosome;GO:0000800|lateral element;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005694|chromosome;GO:0005737|cytoplasm;GO:0005759|mitochondrial matrix;GO:0005886|plasma membrane;GO:0016604|nuclear body;GO:0031436|BRCA1-BARD1 complex;GO:0032991|protein-containing complex;GO:0070531|BRCA1-A complex;GO:1990904|ribonucleoprotein complex;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0003682|chromatin binding;GO:0003684|damaged DNA binding;GO:0003713|transcription coactivator activity;GO:0003723|RNA binding;GO:0004842|ubiquitin-protein transferase activity;GO:0005515|protein binding;GO:0008270|zinc ion binding;GO:0019899|enzyme binding;GO:0031625|ubiquitin protein ligase binding;GO:0070063|RNA polymerase binding;","K10605","BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]"]
["ENSRNOG00000009436",41,2.637547966,1,0.06456186,40.85303583,5.352371385,{"v":3.17446e-11,"d":"3.17E-11"},{"v":3.55566E-11,"d":"3.56E-11"},"up","yes","Hemgn","protein_coding","chr5:60679633-60698669:-","gi|672052524|ref|XP_008761915.1|",2627,0,"PREDICTED: hemogen isoform X1 [Rattus norvegicus]","gi|672052525|ref|XM_008763694.1|",2639,0,"PREDICTED: Rattus norvegicus hemogen (Hemgn), transcript variant X2, mRNA","Q6AZ54",1016,0,"Hemogen",".",".",".",".","pfam11489","DUF3210","Protein of unknown function (DUF3210). This is a family of proteins conserved in yeasts. The function is not known. The Schizosaccharomyces pombe member is SPBC18E5.07 and the Saccharomyces cerevisiae member is AIM21.","GO:0030154|cell differentiation;GO:0045667|regulation of osteoblast differentiation;","GO:0005654|nucleoplasm;",".",".","."]
["ENSRNOG00000050318",198,12.73742676,87,5.61688179,2.26770426,1.181232505,{"v":3.29472e-11,"d":"3.29E-11"},{"v":3.6853e-11,"d":"3.69E-11"},"up","yes","ENSRNOG00000050318","protein_coding","chr9:818263-828185:+","gi|149028240|gb|EDL83678.1|",2583,0,"similar to fibronectin type 3 and SPRY domain-containing protein, isoform CRA_a [Rattus norvegicus]","gi|169642778|gb|BC160924.1|",1630,0,"Rattus norvegicus fibronectin type III and SPRY domain containing 1, mRNA (cDNA clone MGC:188678 IMAGE:8362685), complete cds","Q7TPM6",954,0,"Fibronectin type III and SPRY domain-containing protein 1",".",".",".",".","pfam00622","SPRY","SPRY domain. SPRY Domain is named from SPla and the RYanodine Receptor. Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.",".",".",".",".","."]
["ENSRNOG00000022483",82,5.275095931,18,1.162113474,4.539226203,2.182446384,{"v":3.35236e-11,"d":"3.35E-11"},{"v":3.74904e-11,"d":"3.75E-11"},"up","yes","Trim50","protein_coding","chr12:21300785-21317668:-","gi|564378852|ref|XP_006249190.1|",2506,0,"PREDICTED: E3 ubiquitin-protein ligase TRIM50 isoform X2 [Rattus norvegicus]","gi|672072627|ref|XM_006249128.2|",1942,0,"PREDICTED: Rattus norvegicus tripartite motif-containing 50 (Trim50), transcript variant X1, mRNA","Q810I1",963,0,"E3 ubiquitin-protein ligase TRIM50",".",".",".",".","pfam13765","PRY","SPRY-associated domain. SPRY and PRY domains occur on PYRIN proteins. Their function is not known.","GO:0016567|protein ubiquitination;GO:0070201|regulation of establishment of protein localization;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016235|aggresome;","GO:0008270|zinc ion binding;GO:0042802|identical protein binding;GO:0061630|ubiquitin protein ligase activity;","K12024","TRIM50_73_74; tripartite motif-containing protein 50/73/74"]
["ENSRNOG00000028636",121,7.78398302,39,2.517912527,3.091442986,1.628280399,{"v":3.72562E-11,"d":"3.73E-11"},{"v":4.15915e-11,"d":"4.16E-11"},"up","yes","ENSRNOG00000028636","protein_coding","chr16:70875093-70892967:+","gi|148690274|gb|EDL22221.1|",2833,0,"X Kell blood group precursor-related family, member 5, isoform CRA_b [Mus musculus]","gi|58866029|ref|NM_001012228.1|",2135,0,"Rattus norvegicus XK related 5 (Xkr5), mRNA","Q5GH66",1094,0,"XK-related protein 5",".",".",".",".","pfam09815","XK-related","XK-related protein. Members of this family comprise various XK-related proteins, that are involved in sodium-dependent transport of neutral amino acids or oligopeptides. These proteins are responsible for the Kx blood group system - defects results in McLeod syndrome, an X-linked multi-system disorder characterized by late onset abnormalities in the neuromuscular and hematopoietic systems.","GO:0043652|engulfment of apoptotic cell;GO:0070782|phosphatidylserine exposure on apoptotic cell surface;GO:1902742|apoptotic process involved in development;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000008219",186,11.9654615,80,5.164948772,2.316666056,1.212050097,{"v":5.33735e-11,"d":"5.34E-11"},{"v":5.90875e-11,"d":"5.91E-11"},"up","yes","Ccdc33","protein_coding","chr8:58435661-58534370:-","gi|568961656|ref|XP_006511315.1|",4477,0,"PREDICTED: coiled-coil domain-containing protein 33 isoform X1 [Mus musculus]","gi|62078914|ref|NM_001014091.1|",1876,0,"Rattus norvegicus coiled-coil domain containing 33 (Ccdc33), mRNA","Q3ULW6",1595,0,"Coiled-coil domain-containing protein 33",".",".",".",".","pfam14672","LCE","Late cornified envelope. This is a family of late cornified envelope proteins that are expressed in skin.",".","GO:0005777|peroxisome;",".",".","."]
["ENSRNOG00000038330",253,16.27560086,126,8.134794317,2.000739076,1.000533032,{"v":5.65218e-11,"d":"5.65E-11"},{"v":6.25123e-11,"d":"6.25E-11"},"up","yes","RGD1359508","protein_coding","chr2:124769940-124832449:+","gi|564336321|ref|XP_006232371.1|",602,{"v":8e-72,"d":"8.00E-72"},"PREDICTED: UPF0462 protein C4orf33 homolog isoform X2 [Rattus norvegicus]","gi|305410909|gb|AC241961.3|",854,0,"Rattus norvegicus Y Chr BAC RNECO-233P23 (Amplicon Express Rat SHR-Akr (EcoR1 Digest) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam02673","BacA","Bacitracin resistance protein BacA. Bacitracin resistance protein (BacA) is a putative undecaprenol kinase. BacA confers resistance to bacitracin, probably by phosphorylation of undecaprenol.",".",".",".",".","."]
["ENSRNOG00000031286",243,15.63229648,119,7.682861299,2.034697214,1.024814121,{"v":5.75063E-11,"d":"5.75E-11"},{"v":6.35642e-11,"d":"6.36E-11"},"up","yes","Spin2a","protein_coding","chrX:17511022-17513001:-","gi|319996608|ref|NP_001121129.2|",1252,{"v":3e-169,"d":"3.00E-169"},"spindlin-2 [Rattus norvegicus]","gi|672087135|ref|XM_003752019.3|",1337,0,"PREDICTED: Rattus norvegicus spindlin-2-like (LOC100909485), mRNA","Q6NVE3",467,{"v":4e-163,"d":"4.00E-163"},"Spindlin-2C",".",".",".",".","pfam02513","Spin-Ssty","Spin/Ssty Family. Spindlin (Spin) is a novel maternal transcript present in the unfertilised egg and early embryo. The Y-linked spermiogenesis -specific transcript (Ssty) is also expressed during gametogenesis and forms part of this Pfam family. Members of this family contain three copies of this 50 residue repeat. The repeat is predicted to contain four beta strands.","GO:0006355|regulation of transcription, DNA-templated;GO:0007276|gamete generation;GO:0051726|regulation of cell cycle;","GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0035064|methylated histone binding;",".","."]
["ENSRNOG00000017982",40,2.573217527,0,0.03228093,79.71324064,6.316747476,{"v":5.85887e-11,"d":"5.86E-11"},{"v":6.47355e-11,"d":"6.47E-11"},"up","yes","Pnliprp2","protein_coding","chr1:257897766-257916434:+","gi|17105374|ref|NP_476554.1|",2597,0,"pancreatic lipase-related protein 2 precursor [Rattus norvegicus]","gi|17105373|ref|NM_057206.1|",1536,0,"Rattus norvegicus pancreatic lipase related protein 2 (Pnliprp2), mRNA","P54318",976,0,"Pancreatic lipase-related protein 2",".",".",".",".","pfam00151","Lipase","Lipase.","GO:0006644|phospholipid metabolic process;GO:0006968|cellular defense response;GO:0009395|phospholipid catabolic process;GO:0009617|response to bacterium;GO:0009791|post-embryonic development;GO:0016042|lipid catabolic process;GO:0019376|galactolipid catabolic process;GO:0019433|triglyceride catabolic process;GO:0032094|response to food;GO:0033993|response to lipid;GO:0034638|phosphatidylcholine catabolic process;GO:0043434|response to peptide hormone;GO:0044258|intestinal lipid catabolic process;GO:0051384|response to glucocorticoid;","GO:0005615|extracellular space;GO:0042589|zymogen granule membrane;GO:0043005|neuron projection;","GO:0004620|phospholipase activity;GO:0004806|triglyceride lipase activity;GO:0005509|calcium ion binding;GO:0016298|lipase activity;GO:0047372|acylglycerol lipase activity;GO:0047714|galactolipase activity;GO:0102549|1-18:1-2-16:0-monogalactosyldiacylglycerol lipase activity;","K14075","PNLIPRP2, PLRP2; pancreatic lipase-related protein 2 [EC:3.1.1.3]"]
["ENSRNOG00000067016",130,8.362956964,45,2.905283684,2.87853369,1.525334097,{"v":6.22159e-11,"d":"6.22E-11"},{"v":6.86503e-11,"d":"6.87E-11"},"up","yes","ENSRNOG00000067016","lncRNA","chr17:4937597-4942625:-","gi|149039763|gb|EDL93879.1|",288,{"v":1E-27,"d":"1.00E-27"},"rCG24170, isoform CRA_a [Rattus norvegicus]","gi|672080997|ref|XR_360701.2|",312,{"v":2E-160,"d":"2.00E-160"},"PREDICTED: Rattus norvegicus uncharacterized LOC102547829 (LOC102547829), transcript variant X2, ncRNA",".",".",".",".",".",".",".",".","pfam03708","Avian_gp85","Avian retrovirus envelope protein, gp85. Family of a vain specific viral glycoproteins that forms a receptor-binding gp85 polypeptide that is linked through disulfide to a membrane-spanning gp37 spike. Gp85 confers a high degree of subgroup specificity for interaction with distinct cell receptors.",".",".",".",".","."]
["ENSRNOG00000001092",70,4.503130673,13,0.839304176,5.365314274,2.423662679,{"v":6.82525e-11,"d":"6.83E-11"},{"v":7.51806e-11,"d":"7.52E-11"},"up","yes","Kl","protein_coding","chr12:490399-530080:+","gi|13786168|ref|NP_112626.1|",4910,0,"klotho precursor [Rattus norvegicus]","gi|13786167|ref|NM_031336.1|",3500,0,"Rattus norvegicus Klotho (Kl), mRNA","Q9Z2Y9",1897,0,"Klotho","BH1923",198,{"v":1E-53,"d":"1.00E-53"},"COG2723","pfam00232","Glyco_hydro_1","Glycosyl hydrolase family 1.","GO:0002526|acute inflammatory response;GO:0003085|negative regulation of systemic arterial blood pressure;GO:0005975|carbohydrate metabolic process;GO:0006112|energy reserve metabolic process;GO:0007568|aging;GO:0008286|insulin receptor signaling pathway;GO:0008543|fibroblast growth factor receptor signaling pathway;GO:0014823|response to activity;GO:0030501|positive regulation of bone mineralization;GO:0033280|response to vitamin D;GO:0042421|norepinephrine biosynthetic process;GO:0055074|calcium ion homeostasis;GO:0071774|response to fibroblast growth factor;GO:0090080|positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway;GO:1990776|response to angiotensin;","GO:0005615|extracellular space;GO:0005783|endoplasmic reticulum;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;","GO:0004553|hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0004566|beta-glucuronidase activity;GO:0005104|fibroblast growth factor receptor binding;GO:0008422|beta-glucosidase activity;GO:0017134|fibroblast growth factor binding;","K14756","KL; klotho [EC:3.2.1.31]"]
["ENSRNOG00000006350",109,7.012017762,33,2.130541369,3.291190617,1.718609586,{"v":6.87314e-11,"d":"6.87E-11"},{"v":7.56788e-11,"d":"7.57E-11"},"up","yes","Tle6","protein_coding","chr7:8107207-8118639:+","gi|564358366|ref|XP_006241092.1|",2470,0,"PREDICTED: transducin-like enhancer protein 6 isoform X7 [Rattus norvegicus]","gi|672057938|ref|XM_006241030.2|",1315,0,"PREDICTED: Rattus norvegicus transducin-like enhancer of split 6 (Tle6), transcript variant X7, mRNA","Q9WVB3",697,0,"Transducin-like enhancer protein 6",".",".",".",".","pfam14187","DUF4310","Domain of unknown function (DUF4310). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 214 and 231 amino acids in length.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0007015|actin filament organization;GO:0007284|spermatogonial cell division;GO:0040019|positive regulation of embryonic development;GO:0045666|positive regulation of neuron differentiation;GO:0050769|positive regulation of neurogenesis;GO:0051293|establishment of spindle localization;GO:0051302|regulation of cell division;GO:0051643|endoplasmic reticulum localization;GO:0051646|mitochondrion localization;GO:0060136|embryonic process involved in female pregnancy;GO:0090090|negative regulation of canonical Wnt signaling pathway;","GO:0005634|nucleus;GO:0005667|transcription factor complex;GO:0005737|cytoplasm;GO:0005938|cell cortex;GO:0032991|protein-containing complex;","GO:0003714|transcription corepressor activity;","K04497","GRO, TLE; groucho"]
["ENSRNOG00000013257",128,8.234296088,44,2.840721825,2.898663296,1.535387762,{"v":7.06742e-11,"d":"7.07E-11"},{"v":7.77581E-11,"d":"7.78E-11"},"up","yes","Hecw2","protein_coding","chr9:55365203-55580327:-","gi|157817476|ref|NP_001101688.1|",8253,0,"E3 ubiquitin-protein ligase HECW2 [Rattus norvegicus]","gi|157817475|ref|NM_001108218.1|",5296,0,"Rattus norvegicus HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 (Hecw2), mRNA","Q6I6G8",3086,0,"E3 ubiquitin-protein ligase HECW2","YER125w",409,{"v":3E-122,"d":"3.00E-122"},"COG5021","pfam00632","HECT","HECT-domain (ubiquitin-transferase). The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.","GO:0000209|protein polyubiquitination;GO:0016567|protein ubiquitination;GO:0030071|regulation of mitotic metaphase/anaphase transition;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045732|positive regulation of protein catabolic process;GO:0048814|regulation of dendrite morphogenesis;GO:2000650|negative regulation of sodium ion transmembrane transporter activity;","GO:0005737|cytoplasm;GO:0072686|mitotic spindle;","GO:0016874|ligase activity;GO:0061630|ubiquitin protein ligase activity;","K12168","HECW2; E3 ubiquitin-protein ligase HECW2 [EC:2.3.2.26]"]
["ENSRNOG00000015562",74,4.760452426,15,0.968427895,4.915649839,2.297382151,{"v":8.06249E-11,"d":"8.06E-11"},{"v":8.84506E-11,"d":"8.85E-11"},"up","yes","Cdh17","protein_coding","chr5:25262758-25314884:+","gi|16758872|ref|NP_446429.1|",4316,0,"cadherin-17 precursor [Rattus norvegicus]","gi|505562|emb|X78997.1|",3440,0,"R.norvegicus (Sprague Dawley) mRNA for cadherin","P55281",1667,0,"Cadherin-17",".",".",".",".","pfam00028","Cadherin","Cadherin domain.","GO:0002314|germinal center B cell differentiation;GO:0002315|marginal zone B cell differentiation;GO:0006857|oligopeptide transport;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007229|integrin-mediated signaling pathway;GO:0016339|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0030183|B cell differentiation;GO:0033626|positive regulation of integrin activation by cell surface receptor linked signal transduction;GO:0035672|oligopeptide transmembrane transport;GO:0048536|spleen development;GO:0098742|cell-cell adhesion via plasma-membrane adhesion molecules;","GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016342|catenin complex;GO:0030054|cell junction;","GO:0005178|integrin binding;GO:0005427|proton-dependent oligopeptide secondary active transmembrane transporter activity;GO:0005509|calcium ion binding;GO:0045296|cadherin binding;","K06811","CDH17; cadherin 17, LI cadherin"]
["ENSRNOG00000002826",88,5.66107856,22,1.420360912,3.985662032,1.994819381,{"v":8.84566e-11,"d":"8.85E-11"},{"v":9.68564e-11,"d":"9.69E-11"},"up","yes","Hsd17b7","protein_coding","chr13:82173179-82190017:-","gi|564381646|ref|XP_006250277.1|",1801,0,"PREDICTED: 3-keto-steroid reductase isoform X1 [Rattus norvegicus]","gi|672074766|ref|XM_006250215.2|",1676,0,"PREDICTED: Rattus norvegicus hydroxysteroid (17-beta) dehydrogenase 7 (Hsd17b7), transcript variant X1, mRNA","Q62904",696,0,"3-keto-steroid reductase",".",".",".",".","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.","GO:0006695|cholesterol biosynthetic process;GO:0006703|estrogen biosynthetic process;GO:0007399|nervous system development;GO:0007420|brain development;GO:0008209|androgen metabolic process;GO:0009410|response to xenobiotic stimulus;GO:0014070|response to organic cyclic compound;GO:0021766|hippocampus development;GO:0030154|cell differentiation;GO:0032355|response to estradiol;GO:0048568|embryonic organ development;GO:0048706|embryonic skeletal system development;GO:0060135|maternal process involved in female pregnancy;GO:1990637|response to prolactin;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0000253|3-keto sterol reductase activity;GO:0004303|estradiol 17-beta-dehydrogenase activity;GO:0005148|prolactin receptor binding;GO:0047024|5alpha-androstane-3beta,17beta-diol dehydrogenase activity;GO:0072582|17-beta-hydroxysteroid dehydrogenase (NADP+) activity;","K13373","HSD17B7; 17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase [EC:1.1.1.62 1.1.1.270]"]
["ENSRNOG00000002379",84,5.403756808,20,1.291237193,4.184945134,2.065208709,{"v":9.14722e-11,"d":"9.15E-11"},{"v":1.00082E-10,"d":"1.00E-10"},"up","yes","ENSRNOG00000002379","protein_coding","chrX:132821347-132985668:-","gi|67846068|ref|NP_001020065.1|",936,{"v":2E-120,"d":"2.00E-120"},"placenta-specific protein 1 precursor [Rattus norvegicus]","gi|298908373|emb|FQ228726.1|",1351,0,"Rattus norvegicus TL0ADA52YG08 mRNA sequence","Q4V7E2",365,{"v":6e-122,"d":"6.00E-122"},"Placenta-specific protein 1",".",".",".",".","pfam00100","Zona_pellucida","Zona pellucida-like domain.","GO:0001890|placenta development;GO:0090214|spongiotrophoblast layer developmental growth;","GO:0005576|extracellular region;",".","K25718","PLAC1; placenta-specific protein 1"]
["ENSRNOG00000005038",129,8.298626526,45,2.905283684,2.856391123,1.51419354,{"v":9.29199e-11,"d":"9.29E-11"},{"v":1.01549e-10,"d":"1.02E-10"},"up","yes","Ube2t","protein_coding","chr13:46403375-46414835:+","gi|226823227|ref|NP_001101814.2|",989,{"v":2e-127,"d":"2.00E-127"},"ubiquitin-conjugating enzyme E2 T [Rattus norvegicus]","gi|226823226|ref|NM_001108344.2|",966,0,"Rattus norvegicus ubiquitin-conjugating enzyme E2T (Ube2t), mRNA","Q9CQ37",365,{"v":5e-121,"d":"5.00E-121"},"Ubiquitin-conjugating enzyme E2 T","YDR092w",141,{"v":5e-38,"d":"5.00E-38"},"COG5078","pfam00179","UQ_con","Ubiquitin-conjugating enzyme. Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. TSG101 is one of several UBC homologues that lacks this active site cysteine.","GO:0000209|protein polyubiquitination;GO:0006281|DNA repair;GO:0006513|protein monoubiquitination;GO:0006974|cellular response to DNA damage stimulus;GO:0035519|protein K29-linked ubiquitination;GO:0044314|protein K27-linked ubiquitination;GO:0051865|protein autoubiquitination;GO:0070534|protein K63-linked ubiquitination;GO:0070936|protein K48-linked ubiquitination;GO:0070979|protein K11-linked ubiquitination;GO:0085020|protein K6-linked ubiquitination;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;","GO:0003682|chromatin binding;GO:0004842|ubiquitin-protein transferase activity;GO:0005524|ATP binding;GO:0031625|ubiquitin protein ligase binding;GO:0061631|ubiquitin conjugating enzyme activity;","K13960","UBE2T, HSPC150; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]"]
["ENSRNOG00000011723",244,15.69662692,121,7.811985018,2.009300694,1.006693481,{"v":9.94626E-11,"d":"9.95E-11"},{"v":1.08554E-10,"d":"1.09E-10"},"up","yes","Slc44a3","protein_coding","chr2:209552144-209629044:-","gi|149025835|gb|EDL82078.1|",3113,0,"rCG29044 [Rattus norvegicus]","gi|50925728|gb|BC079142.1|",2244,0,"Rattus norvegicus solute carrier family 44, member 3, mRNA (cDNA clone MGC:94154 IMAGE:7128044), complete cds","Q921V7",1113,0,"Choline transporter-like protein 3",".",".",".",".","pfam04515","Choline_transpo","Plasma-membrane choline transporter. This family represents a high-affinity plasma-membrane choline transporter in C.elegans which is thought to be rate-limiting for ACh synthesis in cholinergic nerve terminals.","GO:0055085|transmembrane transport;","GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0022857|transmembrane transporter activity;","K15282","SLC44A3; solute carrier family 44 (choline transporter-like protein), member 3"]
["ENSRNOG00000001911",39,2.508887089,1,0.06456186,38.86020481,5.2802216,{"v":9.97086e-11,"d":"9.97E-11"},{"v":1.08739E-10,"d":"1.09E-10"},"up","yes","Map6d1","protein_coding","chr11:80734148-80740377:+","gi|157819433|ref|NP_001102314.1|",984,{"v":1e-129,"d":"1.00E-129"},"MAP6 domain-containing protein 1 [Rattus norvegicus]","gi|157819432|ref|NM_001108844.1|",1331,0,"Rattus norvegicus MAP6 domain containing 1 (Map6d1), mRNA","Q14BB9",363,{"v":3e-123,"d":"3.00E-123"},"MAP6 domain-containing protein 1",".",".",".",".","pfam05217","STOP","STOP protein. Neurons contain abundant subsets of highly stable microtubules that resist de-polymerising conditions such as exposure to the cold. Stable microtubules are thought to be essential for neuronal development, maintenance, and function. STOP is a major factor responsible for the intriguing stability properties of neuronal microtubules and is important for synaptic plasticity. Additionally knowledge of STOPs function and properties may help in the treatment of neuroleptics in illnesses such as schizophrenia, currently thought to result from synaptic defects.","GO:0000226|microtubule cytoskeleton organization;GO:0007026|negative regulation of microtubule depolymerization;GO:0018009|N-terminal peptidyl-L-cysteine N-palmitoylation;GO:0030705|cytoskeleton-dependent intracellular transport;GO:0070507|regulation of microtubule cytoskeleton organization;","GO:0005798|Golgi-associated vesicle;GO:0005801|cis-Golgi network;GO:0005874|microtubule;","GO:0005516|calmodulin binding;GO:0008017|microtubule binding;",".","."]
["ENSRNOG00000050123",39,2.508887089,1,0.06456186,38.86020481,5.2802216,{"v":9.97086e-11,"d":"9.97E-11"},{"v":1.08739E-10,"d":"1.09E-10"},"up","yes","Gdf5","protein_coding","chr3:144454338-144458612:-","gi|109471161|ref|XP_001066344.1|",2260,0,"PREDICTED: growth/differentiation factor 5 [Rattus norvegicus]","gi|672017615|ref|XM_001066344.5|",2327,0,"PREDICTED: Rattus norvegicus growth differentiation factor 5 (Gdf5), mRNA","P43027",849,0,"Growth/differentiation factor 5",".",".",".",".","pfam00019","TGF_beta","Transforming growth factor beta like domain.","GO:0007178|transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0009612|response to mechanical stimulus;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0030326|embryonic limb morphogenesis;GO:0030509|BMP signaling pathway;GO:0030513|positive regulation of BMP signaling pathway;GO:0032331|negative regulation of chondrocyte differentiation;GO:0032332|positive regulation of chondrocyte differentiation;GO:0035136|forelimb morphogenesis;GO:0035137|hindlimb morphogenesis;GO:0040014|regulation of multicellular organism growth;GO:0043524|negative regulation of neuron apoptotic process;GO:0043932|ossification involved in bone remodeling;GO:0045666|positive regulation of neuron differentiation;GO:0050680|negative regulation of epithelial cell proliferation;GO:0060390|regulation of SMAD protein signal transduction;GO:0060395|SMAD protein signal transduction;GO:0060591|chondroblast differentiation;GO:2001054|negative regulation of mesenchymal cell apoptotic process;","GO:0005575|cellular_component;GO:0005615|extracellular space;","GO:0005102|signaling receptor binding;GO:0005125|cytokine activity;GO:0008083|growth factor activity;GO:0036122|BMP binding;GO:0042802|identical protein binding;","K04664","GDF5; growth differentiation factor 5"]
["ENSRNOG00000062859",39,2.508887089,1,0.06456186,38.86020481,5.2802216,{"v":9.97086e-11,"d":"9.97E-11"},{"v":1.08739E-10,"d":"1.09E-10"},"up","yes","RGD1565622","protein_coding","chr5:158198851-158228089:-","gi|672020249|ref|XP_008774368.1|",3671,0,"PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 260-like isoform X1, partial [Rattus norvegicus]","gi|672020248|ref|XM_008776146.1|",2205,0,"PREDICTED: Rattus norvegicus RGD1565622 (RGD1565622), transcript variant X1, partial mRNA","Q8TAQ5",550,0,"Zinc finger protein 420",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000046635",156,10.03554836,62,4.002835299,2.507109988,1.326025289,{"v":1.15373E-10,"d":"1.15E-10"},{"v":1.25248e-10,"d":"1.25E-10"},"up","yes","Cdca5","protein_coding","chr1:203378577-203392023:+","gi|672039504|ref|XP_008758398.1|",1097,{"v":4e-143,"d":"4.00E-143"},"PREDICTED: sororin isoform X1 [Rattus norvegicus]","gi|672039503|ref|XM_008760176.1|",1880,0,"PREDICTED: Rattus norvegicus cell division cycle associated 5 (Cdca5), transcript variant X1, mRNA","Q9CPY3",323,{"v":3e-104,"d":"3.00E-104"},"Sororin",".",".",".",".","pfam09666","Sororin","Sororin protein. Sororin is an essential, cell cycle-dependent mediator of sister chromatid cohesion. The protein is nuclear in interphase cells, dispersed from the chromatin in mitosis, and interacts with the cohesin complex.","GO:0000278|mitotic cell cycle;GO:0006302|double-strand break repair;GO:0007064|mitotic sister chromatid cohesion;GO:0007076|mitotic chromosome condensation;GO:0007080|mitotic metaphase plate congression;GO:0031536|positive regulation of exit from mitosis;GO:0051301|cell division;GO:0071922|regulation of cohesin loading;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;","GO:0044877|protein-containing complex binding;","K17390","CDCA5; sororin"]
["ENSRNOG00000026502",179,11.51514844,77,4.971263193,2.316342545,1.211848617,{"v":1.22894e-10,"d":"1.23E-10"},{"v":1.33185e-10,"d":"1.33E-10"},"up","yes","Dscc1","protein_coding","chr7:86482588-86498212:-","gi|765099185|ref|NP_001292165.1|",2019,0,"sister chromatid cohesion protein DCC1 [Rattus norvegicus]","gi|765099184|ref|NM_001305236.1|",1527,0,"Rattus norvegicus DNA replication and sister chromatid cohesion 1 (Dscc1), mRNA","Q14AI0",731,0,"Sister chromatid cohesion protein DCC1",".",".",".",".","pfam09724","DUF2036","Uncharacterized conserved protein (DUF2036). This family of proteins includes members ranging in size from approximately 300 to 460 residues. There are a number of well-conserved domains along the length.","GO:0006260|DNA replication;GO:0006275|regulation of DNA replication;GO:0032508|DNA duplex unwinding;GO:0034088|maintenance of mitotic sister chromatid cohesion;GO:0034421|post-translational protein acetylation;GO:1900264|positive regulation of DNA-directed DNA polymerase activity;","GO:0000775|chromosome, centromeric region;GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0031390|Ctf18 RFC-like complex;","GO:0003689|DNA clamp loader activity;GO:0017116|single-stranded DNA-dependent ATP-dependent DNA helicase activity;","K11271","DSCC1, DCC1; sister chromatid cohesion protein DCC1"]
["ENSRNOG00000030981",162,10.42153099,66,4.261082737,2.445747156,1.290275264,{"v":1.27004e-10,"d":"1.27E-10"},{"v":1.37535e-10,"d":"1.38E-10"},"up","yes","Scnn1b","protein_coding","chr1:176430103-176484451:+","gi|672037689|ref|XP_008757904.1|",3384,0,"PREDICTED: amiloride-sensitive sodium channel subunit beta isoform X1 [Rattus norvegicus]","gi|672037688|ref|XM_008759682.1|",2424,0,"PREDICTED: Rattus norvegicus sodium channel, non-voltage-gated 1, beta subunit (Scnn1b), transcript variant X1, mRNA","P37090",1303,0,"Amiloride-sensitive sodium channel subunit beta",".",".",".",".","pfam00858","ASC","Amiloride-sensitive sodium channel.","GO:0001666|response to hypoxia;GO:0002028|regulation of sodium ion transport;GO:0002269|leukocyte activation involved in inflammatory response;GO:0002283|neutrophil activation involved in immune response;GO:0006814|sodium ion transport;GO:0009410|response to xenobiotic stimulus;GO:0010467|gene expression;GO:0014824|artery smooth muscle contraction;GO:0032094|response to food;GO:0032341|aldosterone metabolic process;GO:0034101|erythrocyte homeostasis;GO:0035264|multicellular organism growth;GO:0035313|wound healing, spreading of epidermal cells;GO:0035725|sodium ion transmembrane transport;GO:0042045|epithelial fluid transport;GO:0050891|multicellular organismal water homeostasis;GO:0050909|sensory perception of taste;GO:0055075|potassium ion homeostasis;GO:0055078|sodium ion homeostasis;GO:0070254|mucus secretion;GO:0070944|neutrophil mediated killing of bacterium;GO:0097274|urea homeostasis;GO:1904045|cellular response to aldosterone;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0030659|cytoplasmic vesicle membrane;GO:0034706|sodium channel complex;GO:0070062|extracellular exosome;GO:0098797|plasma membrane protein complex;","GO:0005272|sodium channel activity;GO:0005515|protein binding;GO:0015081|sodium ion transmembrane transporter activity;GO:0015280|ligand-gated sodium channel activity;GO:0050699|WW domain binding;","K04825","SCNN1B, ENACB; amiloride-sensitive sodium channel subunit beta"]
["ENSRNOG00000064059",41,2.637547966,2,0.129123719,20.42651791,4.352371385,{"v":1.36867e-10,"d":"1.37E-10"},{"v":1.47879E-10,"d":"1.48E-10"},"up","yes","Olr155","protein_coding","chr1:158863230-158867028:+","gi|672037797|ref|XP_006229973.2|",1685,0,"PREDICTED: olfactory receptor Olr155 isoform X1 [Rattus norvegicus]","gi|49615119|gb|AC113720.6|",3063,0,"Rattus norvegicus 1 BAC CH230-117B1 (Children's Hospital Oakland Research Institute) complete sequence","Q8NGI2",330,{"v":3E-102,"d":"3.00E-102"},"Olfactory receptor 52N4",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.",".",".",".",".","."]
["ENSRNOG00000014164",81,5.210765493,19,1.226675333,4.247876639,2.08674187,{"v":1.49346E-10,"d":"1.49E-10"},{"v":1.60936e-10,"d":"1.61E-10"},"up","yes","Paqr5","protein_coding","chr8:62431867-62513688:-","gi|62078917|ref|NP_001014114.1|",1742,0,"membrane progestin receptor gamma [Rattus norvegicus]","gi|62078916|ref|NM_001014092.1|",3701,0,"Rattus norvegicus progestin and adipoQ receptor family member V (Paqr5), mRNA","Q9DCU0",662,0,"Membrane progestin receptor gamma","SPBC12C2.09c",79.3,{"v":6e-15,"d":"6.00E-15"},"COG1272","pfam03006","HlyIII","Haemolysin-III related. Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolizm. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea.",".","GO:0016021|integral component of membrane;","GO:0038023|signaling receptor activity;","K25041","PAQR5, MPRG; membrane progestin receptor gamma"]
["ENSRNOG00000049099",131,8.427287402,47,3.034407404,2.777243224,1.473653531,{"v":1.57344E-10,"d":"1.57E-10"},{"v":1.68949e-10,"d":"1.69E-10"},"up","yes","AABR07017250.1","protein_coding","chr15:18308615-18309382:+","gi|507531076|ref|XP_004649621.1|",655,{"v":2e-84,"d":"2.00E-84"},"PREDICTED: 40S ribosomal protein S10 isoform X2 [Jaculus jaculus]","gi|37194696|gb|BC058141.1|",449,0,"Rattus norvegicus ribosomal protein S10, mRNA (cDNA clone MGC:72791 IMAGE:6921499), complete cds","P63326",241,{"v":7e-80,"d":"7.00E-80"},"40S ribosomal protein S10","SPBP22H7.08",128,{"v":2e-36,"d":"2.00E-36"},"COG5045","pfam03501","S10_plectin","Plectin/S10 domain. This presumed domain is found at the N-terminus of some isoforms of the cytoskeletal muscle protein plectin as well as the ribosomal S10 protein. This domain may be involved in RNA binding.",".",".",".",".","."]
["ENSRNOG00000020106",206,13.25207027,96,6.197938527,2.138141611,1.096357407,{"v":1.86155e-10,"d":"1.86E-10"},{"v":1.99136e-10,"d":"1.99E-10"},"up","yes","Tnfrsf4","protein_coding","chr5:166606909-166609599:+","gi|6981688|ref|NP_037181.1|",1232,{"v":9e-168,"d":"9.00E-168"},"tumor necrosis factor receptor superfamily member 4 precursor [Rattus norvegicus]","gi|6981687|ref|NM_013049.1|",1017,0,"Rattus norvegicus tumor necrosis factor receptor superfamily, member 4 (Tnfrsf4), mRNA","P15725",479,{"v":3e-169,"d":"3.00E-169"},"Tumor necrosis factor receptor superfamily member 4",".",".",".",".","pfam00020","TNFR_c6","TNFR/NGFR cysteine-rich region.","GO:0001818|negative regulation of cytokine production;GO:0002639|positive regulation of immunoglobulin production;GO:0006954|inflammatory response;GO:0006968|cellular defense response;GO:0030890|positive regulation of B cell proliferation;GO:0033209|tumor necrosis factor-mediated signaling pathway;GO:0042098|T cell proliferation;GO:0042981|regulation of apoptotic process;GO:0043433|negative regulation of DNA-binding transcription factor activity;GO:0045859|regulation of protein kinase activity;GO:0045892|negative regulation of transcription, DNA-templated;GO:0070236|negative regulation of activation-induced cell death of T cells;GO:2001237|negative regulation of extrinsic apoptotic signaling pathway;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0005031|tumor necrosis factor-activated receptor activity;","K05142","TNFRSF4, OX40, CD134; tumor necrosis factor receptor superfamily member 4"]
["ENSRNOG00000017873",46,2.959200157,4,0.258247439,11.45877834,3.518381337,{"v":2.13589E-10,"d":"2.14E-10"},{"v":2.27759e-10,"d":"2.28E-10"},"up","yes","Sct","protein_coding","chr1:196382856-196383658:-","gi|12083603|ref|NP_073161.1|",536,{"v":6e-67,"d":"6.00E-67"},"secretin precursor [Rattus norvegicus]","gi|206887|gb|M31495.1|RATSECR",513,0,"Rat secretin mRNA, complete cds","P11384",211,{"v":2e-68,"d":"2.00E-68"},"Secretin",".",".",".",".","pfam00123","Hormone_2","Peptide hormone. This family contains glucagon, GIP, secretin and VIP.","GO:0002024|diet induced thermogenesis;GO:0007165|signal transduction;GO:0007420|brain development;GO:0008542|visual learning;GO:0009992|cellular water homeostasis;GO:0021542|dentate gyrus development;GO:0021766|hippocampus development;GO:0031667|response to nutrient levels;GO:0032098|regulation of appetite;GO:0043524|negative regulation of neuron apoptotic process;GO:0043950|positive regulation of cAMP-mediated signaling;GO:0048167|regulation of synaptic plasticity;GO:0048566|embryonic digestive tract development;GO:0050996|positive regulation of lipid catabolic process;GO:0090187|positive regulation of pancreatic juice secretion;GO:0090274|positive regulation of somatostatin secretion;GO:0097150|neuronal stem cell population maintenance;GO:1903640|negative regulation of gastrin-induced gastric acid secretion;","GO:0005615|extracellular space;","GO:0001664|G protein-coupled receptor binding;GO:0005102|signaling receptor binding;GO:0005179|hormone activity;GO:0046659|digestive hormone activity;GO:0047485|protein N-terminus binding;","K05263","SCT; secretin"]
["ENSRNOG00000027949",46,2.959200157,4,0.258247439,11.45877834,3.518381337,{"v":2.13589E-10,"d":"2.14E-10"},{"v":2.27759e-10,"d":"2.28E-10"},"up","yes","Rfx6","protein_coding","chr20:31019829-31073147:+","gi|564397930|ref|XP_006256506.1|",4823,0,"PREDICTED: DNA-binding protein RFX6 isoform X2 [Rattus norvegicus]","gi|672086182|ref|XM_006256444.2|",3396,0,"PREDICTED: Rattus norvegicus regulatory factor X, 6 (Rfx6), transcript variant X2, mRNA","Q8C7R7",1716,0,"DNA-binding protein RFX6",".",".",".",".","pfam02257","RFX_DNA_binding","RFX DNA-binding domain. RFX is a regulatory factor which binds to the X box of MHC class II genes and is essential for their expression. The DNA-binding domain of RFX is the central domain of the protein and binds ssDNA as either a monomer or homodimer. It recognize X-boxes (DNA of the sequence 5'-GTNRCC(0-3N)RGYAAC-3', where N is any nucleotide, R is a purine and Y is a pyrimidine) using a highly conserved 76-residue DNA-binding domain (DBD).","GO:0003309|type B pancreatic cell differentiation;GO:0003310|pancreatic A cell differentiation;GO:0003311|pancreatic D cell differentiation;GO:0006357|regulation of transcription by RNA polymerase II;GO:0031018|endocrine pancreas development;GO:0035774|positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0042593|glucose homeostasis;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050796|regulation of insulin secretion;GO:0090104|pancreatic epsilon cell differentiation;","GO:0005634|nucleus;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;","K19521","RFX6; regulatory factor X 6"]
["ENSRNOG00000009528",74,4.760452426,16,1.032989754,4.608421724,2.204272746,{"v":2.33599e-10,"d":"2.34E-10"},{"v":2.48585e-10,"d":"2.49E-10"},"up","yes","Sdcbp2","protein_coding","chr3:140070540-140098057:+","gi|71043614|ref|NP_001020863.1|",1487,0,"syntenin-2 [Rattus norvegicus]","gi|672047462|ref|XM_008762326.1|",1412,0,"PREDICTED: Rattus norvegicus syndecan binding protein (syntenin) 2 (Sdcbp2), transcript variant X2, mRNA","Q4KLN0",577,0,"Syntenin-2",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.","GO:0008283|cell proliferation;","GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016607|nuclear speck;","GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0008022|protein C-terminus binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0046982|protein heterodimerization activity;","K17254","SDCBP; syntenin-1"]
["ENSRNOG00000009439",106,6.819026448,33,2.130541369,3.200607389,1.678345716,{"v":2.51151e-10,"d":"2.51E-10"},{"v":2.66816e-10,"d":"2.67E-10"},"up","yes","Eef1a1","protein_coding","chr8:79341557-79344839:-","gi|965955645|ref|XP_014953624.1|",2167,0,"PREDICTED: elongation factor 1-alpha 1-like [Ovis aries]","gi|118764357|gb|BC128723.1|",1341,0,"Rattus norvegicus eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:156575 IMAGE:7312569), complete cds","P62630",800,0,"Elongation factor 1-alpha 1","SPCC794.09c",662,0,"COG5256","pfam00009","GTP_EFTU","Elongation factor Tu GTP binding domain. This domain contains a P-loop motif, also found in several other families such as pfam00071, pfam00025 and pfam00063. Elongation factor Tu consists of three structural domains, this plus two C-terminal beta barrel domains.","GO:0006412|translation;GO:0006414|translational elongation;GO:0007568|aging;GO:0010942|positive regulation of cell death;GO:0010976|positive regulation of neuron projection development;GO:0071364|cellular response to epidermal growth factor stimulus;GO:0071466|cellular response to xenobiotic stimulus;GO:1900022|regulation of D-erythro-sphingosine kinase activity;GO:1903427|negative regulation of reactive oxygen species biosynthetic process;GO:1990090|cellular response to nerve growth factor stimulus;","GO:0005634|nucleus;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005765|lysosomal membrane;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0030864|cortical actin cytoskeleton;GO:0032587|ruffle membrane;","GO:0000049|tRNA binding;GO:0003729|mRNA binding;GO:0003746|translation elongation factor activity;GO:0003924|GTPase activity;GO:0005516|calmodulin binding;GO:0005525|GTP binding;GO:0019900|kinase binding;GO:0019901|protein kinase binding;GO:0042802|identical protein binding;GO:1901363|heterocyclic compound binding;","K03231","EEF1A; elongation factor 1-alpha"]
["ENSRNOG00000066624",116,7.462330829,39,2.517912527,2.963697408,1.567398157,{"v":2.96778e-10,"d":"2.97E-10"},{"v":3.13887e-10,"d":"3.14E-10"},"up","yes","ENSRNOG00000066624","lncRNA","chr14:94563775-94574801:-",".",".",".",".","gi|672028179|ref|XR_340440.2|",2547,0,"PREDICTED: Rattus norvegicus uncharacterized LOC100911950 (LOC100911950), ncRNA",".",".",".",".",".",".",".",".","pfam10977","DUF2797","Protein of unknown function (DUF2797). This family of proteins has no known function.",".",".",".",".","."]
["ENSRNOG00000039949",223,14.34568772,109,7.037242702,2.038538149,1.027534956,{"v":3.20686e-10,"d":"3.21E-10"},{"v":3.38109e-10,"d":"3.38E-10"},"up","yes","Rad54b","protein_coding","chr5:25032066-25104616:+","gi|564350366|ref|XP_006237952.1|",4509,0,"PREDICTED: fibrinogen silencer-binding protein isoform X1 [Rattus norvegicus]","gi|672051958|ref|XM_006237890.2|",2822,0,"PREDICTED: Rattus norvegicus RAD54 homolog B (S. cerevisiae) (Rad54b), transcript variant X1, mRNA","Q6PFE3",1527,0,"DNA repair and recombination protein RAD54B","SPAC15A10.03c",471,{"v":8e-150,"d":"8.00E-150"},"COG0553","pfam00176","SNF2_N","SNF2 family N-terminal domain. This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1).","GO:0000724|double-strand break repair via homologous recombination;GO:0006974|cellular response to DNA damage stimulus;GO:0007131|reciprocal meiotic recombination;GO:0008150|biological_process;GO:0008340|determination of adult lifespan;GO:0009410|response to xenobiotic stimulus;GO:0010212|response to ionizing radiation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;","GO:0003674|molecular_function;GO:0005524|ATP binding;GO:0015616|DNA translocase activity;GO:0042802|identical protein binding;","K10877","RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]"]
["ENSRNOG00000069198",164,10.55019186,69,4.454768316,2.368291932,1.243846928,{"v":3.21884e-10,"d":"3.22E-10"},{"v":3.39247e-10,"d":"3.39E-10"},"up","yes","Lrmda","protein_coding","chr15:1225710-2284749:-","gi|157822121|ref|NP_001102911.1|",1027,{"v":3e-137,"d":"3.00E-137"},"leucine-rich repeat-containing protein C10orf11 homolog [Rattus norvegicus]","gi|157822120|ref|NM_001109441.1|",921,0,"Rattus norvegicus similar to Protein C10orf11 homolog (LOC681383), mRNA","Q9D9B4",360,{"v":3e-123,"d":"3.00E-123"},"Leucine-rich melanocyte differentiation-associated protein",".",".",".",".","pfam14580","LRR_9","Leucine-rich repeat.",".",".",".",".","."]
["ENSRNOG00000020833",220,14.1526964,107,6.908118983,2.048704783,1.034712108,{"v":3.34675e-10,"d":"3.35E-10"},{"v":3.52078e-10,"d":"3.52E-10"},"up","yes","Cspg5","protein_coding","chr8:110220653-110234758:+","gi|41281651|ref|NP_598413.1|",2658,0,"chondroitin sulfate proteoglycan 5 isoform 2 precursor [Rattus norvegicus]","gi|41281650|ref|NM_133652.1|",1704,0,"Rattus norvegicus chondroitin sulfate proteoglycan 5 (Cspg5), transcript variant 2, mRNA","Q9ERQ6",1030,0,"Chondroitin sulfate proteoglycan 5",".",".",".",".","pfam06566","Chon_Sulph_att","Chondroitin sulphate attachment domain. This family represents the chondroitin sulphate attachment domain of vertebrate neural transmembrane proteoglycans that contain EGF modules. Evidence has been accumulated to support the idea that neural proteoglycans are involved in various cellular events including mitogenesis, differentiation, axonal outgrowth and synaptogenesis. This domain contains several potential sites of chondroitin sulphate attachment, as well as potential sites of N-linked glycosylation.","GO:0007010|cytoskeleton organization;GO:0007399|nervous system development;GO:0031103|axon regeneration;GO:0040008|regulation of growth;GO:0048858|cell projection morphogenesis;GO:0050804|modulation of chemical synaptic transmission;GO:0099550|trans-synaptic signaling, modulating synaptic transmission;GO:0106091|glial cell projection elongation;GO:1900026|positive regulation of substrate adhesion-dependent cell spreading;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0000139|Golgi membrane;GO:0005789|endoplasmic reticulum membrane;GO:0005794|Golgi apparatus;GO:0009986|cell surface;GO:0030660|Golgi-associated vesicle membrane;GO:0045202|synapse;GO:0098978|glutamatergic synapse;GO:0098982|GABA-ergic synapse;GO:0099055|integral component of postsynaptic membrane;","GO:0005515|protein binding;","K08116","CSPG5; chondroitin sulfate proteoglycan 5"]
["ENSRNOG00000021303",129,8.298626526,47,3.034407404,2.734842564,1.451457784,{"v":3.44013e-10,"d":"3.44E-10"},{"v":3.61635e-10,"d":"3.62E-10"},"up","yes","Drc3","protein_coding","chr10:45157354-45199369:+","gi|62078449|ref|NP_001013879.1|",2593,0,"dynein regulatory complex subunit 3 [Rattus norvegicus]","gi|672067741|ref|XM_006246465.2|",1814,0,"PREDICTED: Rattus norvegicus leucine rich repeat containing 48 (Lrrc48), transcript variant X6, mRNA","Q5XI54",1003,0,"Dynein regulatory complex subunit 3","SPAC4A8.12c",63.9,{"v":4e-10,"d":"4.00E-10"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.",".","GO:0005737|cytoplasm;GO:0005930|axoneme;GO:0031514|motile cilium;",".","K25443","DRC3; dynein regulatory complex subunit 3"]
["ENSRNOG00000066746",140,9.006261346,54,3.486340421,2.583299465,1.369214895,{"v":3.9072e-10,"d":"3.91E-10"},{"v":4.09829e-10,"d":"4.10E-10"},"up","yes","ENSRNOG00000066746","protein_coding","chr5:69853979-69855728:-","gi|8393418|ref|NP_058704.1|",1671,0,"glyceraldehyde-3-phosphate dehydrogenase [Rattus norvegicus]","gi|402691727|ref|NM_017008.4|",720,0,"Rattus norvegicus glyceraldehyde-3-phosphate dehydrogenase (Gapdh), mRNA","P04797",648,0,"Glyceraldehyde-3-phosphate dehydrogenase","SPBC354.12",478,{"v":3e-167,"d":"3.00E-167"},"COG0057","pfam02800","Gp_dh_C","Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain. GAPDH is a tetrameric NAD-binding enzyme involved in glycolysis and glyconeogenesis. C-terminal domain is a mixed alpha/antiparallel beta fold.",".",".",".",".","."]
["ENSRNOG00000047459",77,4.95344374,18,1.162113474,4.262444117,2.09168092,{"v":3.96773e-10,"d":"3.97E-10"},{"v":4.16103e-10,"d":"4.16E-10"},"up","yes","H1f4","protein_coding","chr17:41486560-41487403:+","gi|281345275|gb|EFB20859.1|",316,{"v":4e-32,"d":"4.00E-32"},"hypothetical protein PANDA_018553, partial [Ailuropoda melanoleuca]","gi|287651|emb|X67320.1|",838,0,"R.norvegicus genes for H1d-histone and H2B-histone","P15865",127,{"v":2e-33,"d":"2.00E-33"},"Histone H1.4",".",".",".",".","pfam00538","Linker_histone","linker histone H1 and H5 family. Linker histone H1 is an essential component of chromatin structure. H1 links nucleosomes into higher order structures Histone H1 is replaced by histone H5 in some cell types.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006334|nucleosome assembly;GO:0006357|regulation of transcription by RNA polymerase II;GO:0016584|nucleosome positioning;GO:0030261|chromosome condensation;GO:0080182|histone H3-K4 trimethylation;GO:0098532|histone H3-K27 trimethylation;","GO:0000785|chromatin;GO:0000786|nucleosome;GO:0000792|heterochromatin;GO:0005634|nucleus;","GO:0000166|nucleotide binding;GO:0003677|DNA binding;GO:0003690|double-stranded DNA binding;GO:0005509|calcium ion binding;GO:0005524|ATP binding;GO:0005525|GTP binding;GO:0016208|AMP binding;GO:0031490|chromatin DNA binding;GO:0032564|dATP binding;GO:0043531|ADP binding;","K11275","H1_5; histone H1/5"]
["ENSRNOG00000004459",121,7.78398302,43,2.776159965,2.803866895,1.487417863,{"v":5.95276E-10,"d":"5.95E-10"},{"v":6.18483e-10,"d":"6.18E-10"},"up","yes","Sdr9c7","protein_coding","chr7:63707071-63721480:+","gi|564308558|ref|XP_006226116.1|",1670,0,"PREDICTED: short-chain dehydrogenase/reductase family 9C member 7 [Rattus norvegicus]","gi|672021766|ref|XM_006226055.2|",2551,0,"PREDICTED: Rattus norvegicus short chain dehydrogenase/reductase family 9C, member 7 (Sdr9c7), transcript variant X4, mRNA","Q8K3P0",617,0,"Short-chain dehydrogenase/reductase family 9C member 7",".",".",".",".","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.",".",".","GO:0004745|retinol dehydrogenase activity;","K24425","SDR9C7; short-chain dehydrogenase/reductase family 9C member 7 [EC:1.1.1.-]"]
["ENSRNOG00000008025",168,10.80751362,73,4.713015755,2.293120621,1.197312245,{"v":6.59206e-10,"d":"6.59E-10"},{"v":6.82176e-10,"d":"6.82E-10"},"up","yes","Bend5","protein_coding","chr5:125254956-126534367:+","gi|545746414|ref|NP_001271119.1|",2618,0,"cytosolic carboxypeptidase 6 isoform 3 [Mus musculus]","gi|672019738|ref|XM_008776038.1|",2062,0,"PREDICTED: Rattus norvegicus cytosolic carboxypeptidase 6-like (LOC100911395), transcript variant X1, mRNA","Q5VU57",949,0,"Cytosolic carboxypeptidase 6","RSc2008",119,{"v":2e-27,"d":"2.00E-27"},"COG2866","pfam00246","Peptidase_M14","Zinc carboxypeptidase.","GO:0045892|negative regulation of transcription, DNA-templated;","GO:0005794|Golgi apparatus;","GO:0003677|DNA binding;",".","."]
["ENSRNOG00000067648",212,13.6380529,103,6.649871544,2.050874638,1.036239308,{"v":6.6586e-10,"d":"6.66E-10"},{"v":6.88688e-10,"d":"6.89E-10"},"up","yes","ENSRNOG00000067648","protein_coding","chr4:169672423-169672734:-","gi|351709298|gb|EHB12217.1|",416,{"v":2E-50,"d":"2.00E-50"},"Histone H4 [Heterocephalus glaber]","gi|672051585|ref|XM_008763448.1|",312,{"v":3e-161,"d":"3.00E-161"},"PREDICTED: Rattus norvegicus histone H4 variant H4-v.1 (RGD1562378), mRNA","Q28DR4",163,{"v":3E-51,"d":"3.00E-51"},"Histone H4",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.",".",".",".",".","."]
["ENSRNOG00000009116",219,14.08836596,108,6.972680843,2.020509225,1.014718938,{"v":6.92752e-10,"d":"6.93E-10"},{"v":7.15723e-10,"d":"7.16E-10"},"up","yes","Itgb3bp","protein_coding","chr5:114460221-114525704:-","gi|61557307|ref|NP_001013231.1|",901,{"v":2e-117,"d":"2.00E-117"},"centromere protein R [Rattus norvegicus]","gi|61557306|ref|NM_001013213.1|",705,0,"Rattus norvegicus integrin subunit beta 3 binding protein (Itgb3bp), mRNA","Q5U1Z7",351,{"v":7e-119,"d":"7.00E-119"},"Centromere protein R",".",".",".",".","pfam06729","CENP-R","Kinetochore component, CENP-R. This family consists of mammalian kinetochore sub-complex proteins CENP-R, also referred to as nuclear receptor co-activator NRIF3 proteins. NRIF3 exhibits a distinct receptor specificity in interacting with and potentiating the activity of only TRs and RXRs but not other examined nuclear receptors. NRIF3 as a co-regulator that possesses both transactivation and transrepression domains and/or functions. Collectively, the NRIF3 family of co-regulators may play dual roles in mediating both positive and negative regulatory effects on gene expression. CENP-R is one of the 15 components that make up the constitutive centromere associated complex (CCAN) part of the kinetochore. A sub-complex of CCAN, consisting of CENP-P/O/R/Q/U self-assembles on kinetochores with varying stoichiometry and undergoes a pre-mitotic maturation step. Kinetochore assembly is a cell cycle regulated multi-step process. The initial step occurs during interphase and involves loading of the 15-subunit constitutive centromere associated complex (CCAN). Kinetochores are multi-protein megadalton assemblies that are required for attachment of microtubules to centromeres and, in turn, the segregation of chromosomes in mitosis.","GO:0006355|regulation of transcription, DNA-templated;GO:0006915|apoptotic process;GO:0034080|CENP-A containing nucleosome assembly;GO:0051301|cell division;","GO:0000776|kinetochore;GO:0005634|nucleus;GO:0005654|nucleoplasm;",".","K11510","ITGB3BP, CENPR; centromere protein R"]
["ENSRNOG00000025126",209,13.44506158,101,6.520747825,2.061889517,1.04396703,{"v":6.93321e-10,"d":"6.93E-10"},{"v":7.16182e-10,"d":"7.16E-10"},"up","yes","Palb2","protein_coding","chr1:176665076-176688990:-","gi|300797913|ref|NP_001178532.1|",5499,0,"partner and localizer of BRCA2 [Rattus norvegicus]","gi|300797912|ref|NM_001191603.1|",3525,0,"Rattus norvegicus partner and localizer of BRCA2 (Palb2), mRNA","Q3U0P1",1719,0,"Partner and localizer of BRCA2",".",".",".",".","pfam05109","Herpes_BLLF1","Herpes virus major outer envelope glycoprotein (BLLF1). This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralizing antibodies in vivo.","GO:0000724|double-strand break repair via homologous recombination;GO:0001701|in utero embryonic development;GO:0001756|somitogenesis;GO:0001833|inner cell mass cell proliferation;GO:0007498|mesoderm development;GO:0008150|biological_process;GO:0009887|animal organ morphogenesis;GO:0035264|multicellular organism growth;GO:0036342|post-anal tail morphogenesis;GO:0043066|negative regulation of apoptotic process;GO:0048568|embryonic organ development;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0032991|protein-containing complex;","GO:0003674|molecular_function;GO:0003677|DNA binding;","K10897","PALB2, FANCN; partner and localizer of BRCA2"]
["ENSRNOG00000057458",191,12.28711369,89,5.746005509,2.138374854,1.096514778,{"v":8.42677E-10,"d":"8.43E-10"},{"v":8.64987E-10,"d":"8.65E-10"},"up","yes","Oip5","protein_coding","chr3:106593760-106603250:-","gi|149023022|gb|EDL79916.1|",1258,{"v":2e-164,"d":"2.00E-164"},"similar to Opa-interacting protein 5 (predicted) [Rattus norvegicus]","gi|672017204|ref|XR_085783.4|",1480,0,"PREDICTED: Rattus norvegicus Opa interacting protein 5 (Oip5), misc_RNA","A2AQ14",388,{"v":9e-127,"d":"9.00E-127"},"Protein Mis18-beta",".",".",".",".","pfam03226","Yippee-Mis18","Yippee zinc-binding/DNA-binding /Mis18, centromere assembly. This family includes both Yippee-type proteins and Mis18 kinetochore proteins. Yippee are putative zinc-binding/DNA-binding proteins. Mis18 are proteins involved in the priming of centromeres for recruiting CENP-A. Mis18-alpha and beta form part of a small complex with Mis18-binding protein. Mis18-alpha is found to interact with DNA de-methylases through a Leu-rich region located at its carboxyl terminus.","GO:0051301|cell division;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0010369|chromocenter;GO:0015030|Cajal body;GO:0016607|nuclear speck;GO:0043231|intracellular membrane-bounded organelle;","GO:0042802|identical protein binding;GO:0046872|metal ion binding;","K11565","OIP5; opa-interacting protein 5"]
["ENSRNOG00000067479",155,9.971217919,65,4.196520878,2.37606775,1.248575973,{"v":8.72731e-10,"d":"8.73E-10"},{"v":8.95354e-10,"d":"8.95E-10"},"up","yes","Hlf","protein_coding","chr10:75154507-75211935:-","gi|564313180|ref|XP_006220842.1|",1301,{"v":9e-162,"d":"9.00E-162"},"PREDICTED: hepatic leukemia factor isoform X1 [Rattus norvegicus]","gi|564373807|ref|XM_006247136.1|",5303,0,"PREDICTED: Rattus norvegicus similar to hepatic leukemia factor (LOC690286), transcript variant X1, mRNA","Q64709",496,{"v":1e-159,"d":"1.00E-159"},"Hepatic leukemia factor",".",".",".",".","pfam07716","bZIP_2","Basic region leucine zipper.",".",".",".",".","."]
["ENSRNOG00000001872",205,13.18773983,99,6.391624106,2.063284638,1.04494286,{"v":9.77907e-10,"d":"9.78E-10"},{"v":1.0011E-9,"d":"1.00E-09"},"up","yes","Lrrc74b","protein_coding","chr11:83450624-83468922:+","gi|672026317|ref|XP_003752590.2|",1911,0,"PREDICTED: LOW QUALITY PROTEIN: leucine-rich repeat-containing protein homolog [Rattus norvegicus]","gi|672071833|ref|XM_003751096.3|",1771,0,"PREDICTED: Rattus norvegicus nucleotide-binding oligomerization domain containing 2-like (LOC100361946), mRNA",".",".",".",".",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.",".",".",".",".","."]
["ENSRNOG00000067344",150,9.649565728,62,4.002835299,2.410682681,1.269441761,{"v":9.95919e-10,"d":"9.96E-10"},{"v":1.01826E-9,"d":"1.02E-09"},"up","yes","ENSRNOG00000067344","protein_coding","chr9:113440157-113676688:+","gi|672070366|ref|XP_008766739.1|",2337,0,"PREDICTED: zinc finger protein 431-like isoform X3 [Rattus norvegicus]","gi|672018984|ref|XR_600914.1|",1708,0,"PREDICTED: Rattus norvegicus zinc finger protein 120-like (LOC102557117), misc_RNA","Q6P3V2",673,0,"Zinc finger protein 585A",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000066293",92,5.918400313,27,1.743170211,3.395193583,1.763493835,{"v":1.04739E-9,"d":"1.05E-09"},{"v":1.06973E-9,"d":"1.07E-09"},"up","yes","ENSRNOG00000066293","lncRNA","chr19:13740964-13768610:-","gi|672033587|ref|XP_008756475.1|",339,{"v":1e-34,"d":"1.00E-34"},"PREDICTED: uncharacterized protein LOC501421 isoform X1 [Rattus norvegicus]","gi|425703057|gb|AC246664.5|",604,0,"Rattus norvegicus Y Chr BAC RNAEX-360A21 (Amplicon Express Rat SHR-Akr BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam09727","CortBP2","Cortactin-binding protein-2. This entry is the first approximately 250 residues of cortactin-binding protein 2. In addition to being a positional candidate for autism this protein is expressed at highest levels in the brain in humans. The human protein has six associated ankyrin repeat domains pfam00023 towards the C-terminus which act as protein-protein interaction domains.",".",".",".",".","."]
["ENSRNOG00000023496",58,3.731165415,10,0.645618597,5.779209946,2.530872281,{"v":1.14693e-09,"d":"1.15E-09"},{"v":1.16973e-09,"d":"1.17E-09"},"up","yes","Fam189a1","protein_coding","chr1:118288379-118700671:-","gi|166795260|ref|NP_898910.2|",2266,0,"protein FAM189A1 [Mus musculus]","gi|166795259|ref|NM_183087.4|",3018,0,"Mus musculus family with sequence similarity 189, member A1 (Fam189a1), mRNA","Q6A044",877,0,"Protein FAM189A1",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000052080",86,5.532417684,24,1.549484632,3.570488904,1.836121635,{"v":1.31273e-09,"d":"1.31E-09"},{"v":1.33382e-09,"d":"1.33E-09"},"up","yes","Camk2b","protein_coding","chr14:80845238-80933994:-","gi|532046912|ref|XP_005366245.1|",3059,0,"PREDICTED: calcium/calmodulin-dependent protein kinase type II subunit beta isoform X5 [Microtus ochrogaster]","gi|755536160|ref|XM_006514465.2|",3340,0,"PREDICTED: Mus musculus calcium/calmodulin-dependent protein kinase II, beta (Camk2b), transcript variant X3, mRNA","Q13554",1172,0,"Calcium/calmodulin-dependent protein kinase type II subunit beta",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0000082|G1/S transition of mitotic cell cycle;GO:0002030|inhibitory G protein-coupled receptor phosphorylation;GO:0006468|protein phosphorylation;GO:0006816|calcium ion transport;GO:0010976|positive regulation of neuron projection development;GO:0018105|peptidyl-serine phosphorylation;GO:0032222|regulation of synaptic transmission, cholinergic;GO:0032430|positive regulation of phospholipase A2 activity;GO:0046686|response to cadmium ion;GO:0046777|protein autophosphorylation;GO:0048169|regulation of long-term neuronal synaptic plasticity;GO:0048858|cell projection morphogenesis;GO:0050885|neuromuscular process controlling balance;GO:0060291|long-term synaptic potentiation;GO:0060466|activation of meiosis involved in egg activation;GO:0061003|positive regulation of dendritic spine morphogenesis;GO:0090129|positive regulation of synapse maturation;GO:0098974|postsynaptic actin cytoskeleton organization;GO:0110088|hippocampal neuron apoptotic process;GO:1903076|regulation of protein localization to plasma membrane;GO:1905375|cellular response to homocysteine;GO:1990911|response to psychosocial stress;GO:2001222|regulation of neuron migration;GO:2001235|positive regulation of apoptotic signaling pathway;","GO:0005737|cytoplasm;GO:0005815|microtubule organizing center;GO:0005829|cytosol;GO:0005954|calcium- and calmodulin-dependent protein kinase complex;GO:0014069|postsynaptic density;GO:0030425|dendrite;GO:0033017|sarcoplasmic reticulum membrane;GO:0043005|neuron projection;GO:0043204|perikaryon;GO:0051233|spindle midzone;GO:0098978|glutamatergic synapse;","GO:0004674|protein serine/threonine kinase activity;GO:0004683|calmodulin-dependent protein kinase activity;GO:0005515|protein binding;GO:0005516|calmodulin binding;GO:0005524|ATP binding;GO:0019901|protein kinase binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0043274|phospholipase binding;GO:0098973|structural constituent of postsynaptic actin cytoskeleton;","K04515","CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]"]
["ENSRNOG00000018250",179,11.51514844,82,5.294072492,2.175102145,1.121083153,{"v":1.46588e-09,"d":"1.47E-09"},{"v":1.48363E-9,"d":"1.48E-09"},"up","yes","Tnni3","protein_coding","chr1:69299900-69303580:+","gi|8394469|ref|NP_058840.1|",877,{"v":7e-116,"d":"7.00E-116"},"troponin I, cardiac muscle [Rattus norvegicus]","gi|402744875|ref|NM_017144.2|",802,0,"Rattus norvegicus troponin I3, cardiac type (Tnni3), mRNA","P23693",342,{"v":2e-117,"d":"2.00E-117"},"Troponin I, cardiac muscle",".",".",".",".","pfam00992","Troponin","Troponin. Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). this Pfam contains members of the TnT subunit. Troponin is a complex of three proteins, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). The troponin complex regulates Ca++ induced muscle contraction. This family includes troponin T and troponin I. Troponin I binds to actin and troponin T binds to tropomyosin.","GO:0001570|vasculogenesis;GO:0001980|regulation of systemic arterial blood pressure by ischemic conditions;GO:0003009|skeletal muscle contraction;GO:0006874|cellular calcium ion homeostasis;GO:0006936|muscle contraction;GO:0006937|regulation of muscle contraction;GO:0006940|regulation of smooth muscle contraction;GO:0006941|striated muscle contraction;GO:0007507|heart development;GO:0010882|regulation of cardiac muscle contraction by calcium ion signaling;GO:0032780|negative regulation of ATPase activity;GO:0055010|ventricular cardiac muscle tissue morphogenesis;GO:0060047|heart contraction;GO:0060048|cardiac muscle contraction;","GO:0005737|cytoplasm;GO:0005861|troponin complex;GO:0030016|myofibril;GO:0030017|sarcomere;GO:0043292|contractile fiber;GO:0097512|cardiac myofibril;GO:1990584|cardiac Troponin complex;","GO:0003779|actin binding;GO:0005515|protein binding;GO:0019855|calcium channel inhibitor activity;GO:0019901|protein kinase binding;GO:0019904|protein domain specific binding;GO:0030172|troponin C binding;GO:0031014|troponin T binding;GO:0046872|metal ion binding;GO:0048306|calcium-dependent protein binding;GO:0051015|actin filament binding;","K12044","TNNI3; troponin I, cardiac muscle"]
["ENSRNOG00000000499",82,5.275095931,22,1.420360912,3.713912348,1.892939767,{"v":1.47984e-09,"d":"1.48E-09"},{"v":1.49696E-9,"d":"1.50E-09"},"up","yes","Tcp11","protein_coding","chr20:6126269-6136055:-","gi|56090245|ref|NP_001007696.1|",2625,0,"T-complex protein 11 homolog [Rattus norvegicus]","gi|56090244|ref|NM_001007695.1|",1909,0,"Rattus norvegicus t-complex protein 11 (Tcp11), mRNA","Q5XI00",1015,0,"T-complex protein 11 homolog",".",".",".",".","pfam05794","Tcp11","T-complex protein 11. This family consists of several eukaryotic T-complex protein 11 (Tcp11) related sequences. Tcp11 is only expressed in fertile adult mammalian testes and is thought to be important in sperm function and fertility. The family also contains the yeast Sok1 protein which is known to suppress cyclic AMP-dependent protein kinase mutants.","GO:0007165|signal transduction;GO:0007283|spermatogenesis;GO:0010737|protein kinase A signaling;GO:0030154|cell differentiation;GO:0043949|regulation of cAMP-mediated signaling;GO:0045920|negative regulation of exocytosis;GO:1902490|regulation of sperm capacitation;","GO:0001669|acrosomal vesicle;GO:0016021|integral component of membrane;GO:0036126|sperm flagellum;GO:0097225|sperm midpiece;",".","K25628","TCP11; T-complex protein 11"]
["ENSRNOG00000021009",82,5.275095931,22,1.420360912,3.713912348,1.892939767,{"v":1.47984e-09,"d":"1.48E-09"},{"v":1.49696E-9,"d":"1.50E-09"},"up","yes","Gapdhs","protein_coding","chr1:85979098-85993640:-","gi|564327416|ref|XP_006228852.1|",1831,0,"PREDICTED: glyceraldehyde-3-phosphate dehydrogenase, testis-specific isoform X1 [Rattus norvegicus]","gi|672035865|ref|XM_006228790.2|",1438,0,"PREDICTED: Rattus norvegicus glyceraldehyde-3-phosphate dehydrogenase, spermatogenic (Gapdhs), transcript variant X1, mRNA","Q9ESV6",709,0,"Glyceraldehyde-3-phosphate dehydrogenase, testis-specific","SPBC354.12",481,{"v":2E-167,"d":"2.00E-167"},"COG0057","pfam02800","Gp_dh_C","Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain. GAPDH is a tetrameric NAD-binding enzyme involved in glycolysis and glyconeogenesis. C-terminal domain is a mixed alpha/antiparallel beta fold.","GO:0006006|glucose metabolic process;GO:0006096|glycolytic process;GO:0007286|spermatid development;GO:0030317|flagellated sperm motility;","GO:0001669|acrosomal vesicle;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005929|cilium;GO:0031514|motile cilium;GO:0035686|sperm fibrous sheath;GO:0097228|sperm principal piece;","GO:0003674|molecular_function;GO:0004365|glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity;GO:0050661|NADP binding;GO:0051287|NAD binding;","K10705","GAPDHS; glyceraldehyde-3-phosphate dehydrogenase (phosphorylating), spermatogenic [EC:1.2.1.12]"]
["ENSRNOG00000004461",205,13.18773983,100,6.456185966,2.042651791,1.03044329,{"v":1.50978e-09,"d":"1.51E-09"},{"v":1.5267e-09,"d":"1.53E-09"},"up","yes","NEWGENE_6497122","protein_coding","chr10:12798762-12806439:-","gi|149051960|gb|EDM03777.1|",605,{"v":1e-75,"d":"1.00E-75"},"rCG33321, isoform CRA_b [Rattus norvegicus]","gi|672024573|ref|XM_008774681.1|",493,0,"PREDICTED: Rattus norvegicus FLYWCH-type zinc finger 1 (Flywch1), transcript variant X6, mRNA",".",".",".",".",".",".",".",".","pfam15423","FLYWCH_N","FLYWCH-type zinc finger-containing protein. This family is the N-terminus of some FLYWCH-zinc-finger proteins, found in eukaryotes. The family is found in association with pfam04500. There are two conserved sequence motifs: EQE and QEPS.","GO:0008150|biological_process;","GO:0005575|cellular_component;","GO:0003674|molecular_function;",".","."]
["ENSRNOG00000008463",80,5.146435055,21,1.355799053,3.795868602,1.924430053,{"v":1.55396e-09,"d":"1.55E-09"},{"v":1.56915e-09,"d":"1.57E-09"},"up","yes","Rundc3b","protein_coding","chr4:25462752-25599471:+","gi|564345554|ref|XP_006236065.1|",2142,0,"PREDICTED: RUN domain-containing protein 3B isoform X1 [Rattus norvegicus]","gi|672048919|ref|XM_006236003.2|",3740,0,"PREDICTED: Rattus norvegicus RUN domain containing 3B (Rundc3b), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam02759","RUN","RUN domain. This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.",".",".",".","K24787","RUNDC3; RUN domain-containing protein 3"]
["ENSRNOG00000062479",105,6.754696009,35,2.259665088,2.989246524,1.579781881,{"v":1.65292e-09,"d":"1.65E-09"},{"v":1.66555e-09,"d":"1.67E-09"},"up","yes","ENSRNOG00000062479","protein_coding","chr2:215692196-215697408:+","gi|293347239|ref|XP_002726534.1|",651,{"v":2e-69,"d":"2.00E-69"},"PREDICTED: uncharacterized protein LOC100364265 [Rattus norvegicus]","gi|33457292|gb|AC131744.3|",1640,0,"Mus musculus BAC clone RP23-50E10 from chromosome 3, complete sequence","P11260",155,{"v":3e-39,"d":"3.00E-39"},"LINE-1 retrotransposable element ORF1 protein",".",".",".",".","pfam02994","Transposase_22","L1 transposable element.",".",".",".",".","."]
["ENSRNOG00000064022",74,4.760452426,18,1.162113474,4.096374866,2.034347745,{"v":1.70485E-9,"d":"1.70E-09"},{"v":1.71667E-9,"d":"1.72E-09"},"up","yes","ENSRNOG00000064022","lncRNA","chr10:5273404-5277370:+",".",".",".",".","gi|672024497|ref|XR_598611.1|",690,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102553451 (LOC102553451), transcript variant X3, ncRNA",".",".",".",".",".",".",".",".","pfam11477","PM0188","Sialyltransferase PMO188. PMO188 is a sialyltransferase from P.multocida. It transfers sialic acid from cytidine 5'-monophosphonuraminic acid to an acceptor sugar. It has important catalytic residues such as Asp141, His311, Glu338, Ser355 and Ser356.",".",".",".",".","."]
["ENSRNOG00000020484",89,5.725408998,26,1.678608351,3.410806931,1.770113093,{"v":1.77325e-09,"d":"1.77E-09"},{"v":1.78365e-09,"d":"1.78E-09"},"up","yes","Trpm5","protein_coding","chr1:198255723-198277654:-","gi|672039451|ref|XP_008758382.1|",6111,0,"PREDICTED: transient receptor potential cation channel subfamily M member 5 isoform X1 [Rattus norvegicus]","gi|300798669|ref|NM_001191896.1|",3471,0,"Rattus norvegicus transient receptor potential cation channel, subfamily M, member 5 (Trpm5), mRNA","Q9JJH7",2234,0,"Transient receptor potential cation channel subfamily M member 5",".",".",".",".","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0019722|calcium-mediated signaling;GO:0034220|ion transmembrane transport;GO:0035725|sodium ion transmembrane transport;GO:0050909|sensory perception of taste;GO:0070588|calcium ion transmembrane transport;GO:0071805|potassium ion transmembrane transport;GO:0098655|cation transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0030425|dendrite;GO:0043025|neuronal cell body;","GO:0005227|calcium activated cation channel activity;GO:0005261|cation channel activity;GO:0005267|potassium channel activity;GO:0005272|sodium channel activity;GO:0099604|ligand-gated calcium channel activity;","K04980","TRPM5; transient receptor potential cation channel subfamily M member 5"]
["ENSRNOG00000056226",157,10.0998788,68,4.390206457,2.30054757,1.201977288,{"v":2.11918e-09,"d":"2.12E-09"},{"v":2.1245e-09,"d":"2.12E-09"},"up","yes","Cenpq","protein_coding","chr9:19957048-19972789:+","gi|62079165|ref|NP_001014237.1|",1323,{"v":3e-179,"d":"3.00E-179"},"centromere protein Q [Rattus norvegicus]","gi|62079164|ref|NM_001014215.1|",1415,0,"Rattus norvegicus centromere protein Q (Cenpq), mRNA","Q66H02",514,{"v":1E-180,"d":"1.00E-180"},"Centromere protein Q",".",".",".",".","pfam13094","CENP-Q","CENP-Q, a CENPA-CAD centromere complex subunit. CENP-Q is one of the components that assembles onto the CENPA-nucleosome distal (CAD) centromere. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENPA nucleosomes directly recruit a proximal CENPA-nucleosome-associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENPA NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENPA-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC. Fta7 is the equivalent component of the fission yeast Sim4 complex.",".",".",".",".","."]
["ENSRNOG00000013698",42,2.701878404,4,0.258247439,10.46236283,3.387136803,{"v":2.27519e-09,"d":"2.28E-09"},{"v":2.2769e-09,"d":"2.28E-09"},"up","yes","ENSRNOG00000013698","protein_coding","chrX:114965767-115005278:+","gi|564323265|ref|XP_006227579.1|",2198,0,"PREDICTED: testin [Rattus norvegicus]","gi|672032704|ref|XM_006227517.2|",1453,0,"PREDICTED: Rattus norvegicus similar to hypothetical protein (RGD1566387), transcript variant X1, mRNA","Q2LAP6",668,0,"Testin",".",".",".",".","pfam06297","PET","PET Domain. This domain is suggested to be involved in protein-protein interactions. The family is found in conjunction with pfam00412.","GO:0042127|regulation of cell proliferation;","GO:0005737|cytoplasm;GO:0005925|focal adhesion;","GO:0008270|zinc ion binding;",".","."]
["ENSRNOG00000048195",196,12.60876588,95,6.133376667,2.055762522,1.039673616,{"v":2.63961e-09,"d":"2.64E-09"},{"v":2.631e-09,"d":"2.63E-09"},"up","yes","Nudt13","protein_coding","chr15:4001794-4022293:-","gi|189083707|ref|NP_001121108.1|",1754,0,"nucleoside diphosphate-linked moiety X motif 13 [Rattus norvegicus]","gi|189083706|ref|NM_001127636.1|",2394,0,"Rattus norvegicus nudix hydrolase 13 (Nudt13), mRNA","Q8JZU0",635,0,"Nucleoside diphosphate-linked moiety X motif 13","mll5500",137,{"v":2e-34,"d":"2.00E-34"},"COG2816","pfam09296","NUDIX-like","NADH pyrophosphatase-like rudimentary NUDIX domain. The N-terminal domain in NADH pyrophosphatase, which has a rudiment Nudix fold according to SCOP.","GO:0006734|NADH metabolic process;GO:0006742|NADP catabolic process;","GO:0005739|mitochondrion;","GO:0000210|NAD+ diphosphatase activity;GO:0035529|NADH pyrophosphatase activity;GO:0046872|metal ion binding;",".","."]
["ENSRNOG00000062469",100,6.433043818,33,2.130541369,3.019440933,1.594281451,{"v":3.17083e-09,"d":"3.17E-09"},{"v":3.14676E-9,"d":"3.15E-09"},"up","yes","Ccdc194","protein_coding","chr16:18205095-18209283:-","gi|407263515|ref|XP_003945491.1|",558,{"v":6e-64,"d":"6.00E-64"},"PREDICTED: nestin [Mus musculus]","gi|755526175|ref|XM_011242347.1|",795,0,"PREDICTED: Mus musculus RIKEN cDNA C430049E01 gene (C430049E01Rik), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam15547","DUF4654","Domain of unknown function (DUF4654). This family of proteins is found in eukaryotes. Proteins in this family are typically between 145 and 169 amino acids in length. There is a conserved IDC sequence motif.",".",".",".",".","."]
["ENSRNOG00000017716",56,3.602504538,10,0.645618597,5.579926845,2.480246208,{"v":3.34682e-09,"d":"3.35E-09"},{"v":3.31681e-09,"d":"3.32E-09"},"up","yes","Ucp3","protein_coding","chr1:154815777-154828762:+","gi|7110733|ref|NP_037299.1|",1653,0,"mitochondrial uncoupling protein 3 [Rattus norvegicus]","gi|48675842|ref|NM_013167.2|",2373,0,"Rattus norvegicus uncoupling protein 3 (mitochondrial, proton carrier) (Ucp3), mRNA","P56499",641,0,"Mitochondrial uncoupling protein 3",".",".",".",".","pfam00153","Mito_carr","Mitochondrial carrier protein.","GO:0000303|response to superoxide;GO:0001666|response to hypoxia;GO:0006631|fatty acid metabolic process;GO:0007568|aging;GO:0007584|response to nutrient;GO:0009409|response to cold;GO:0014823|response to activity;GO:0032868|response to insulin;GO:0032870|cellular response to hormone stimulus;GO:0048545|response to steroid hormone;GO:0051384|response to glucocorticoid;GO:1902600|proton transmembrane transport;GO:1990542|mitochondrial transmembrane transport;GO:1990845|adaptive thermogenesis;","GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0016021|integral component of membrane;","GO:0015078|proton transmembrane transporter activity;GO:0017077|oxidative phosphorylation uncoupler activity;","K15103","UCP2_3, SLC25A8_9; solute carrier family 25 (mitochondrial uncoupling protein), member 8/9"]
["ENSRNOG00000065214",123,7.912643897,47,3.034407404,2.607640585,1.382745034,{"v":3.43035e-09,"d":"3.43E-09"},{"v":3.39545e-09,"d":"3.40E-09"},"up","yes","ENSRNOG00000065214","protein_coding","chr1:117222298-117223587:+","gi|149055516|gb|EDM07100.1|",528,{"v":4e-59,"d":"4.00E-59"},"rCG38177, isoform CRA_a [Rattus norvegicus]","gi|451958139|ref|NM_001276434.1|",1206,0,"Rattus norvegicus high mobility group nucleosome binding domain 5 (Hmgn5), mRNA","B4F777",207,{"v":2e-60,"d":"2.00E-60"},"High mobility group nucleosome-binding domain-containing protein 5",".",".",".",".","pfam01101","HMG14_17","HMG14 and HMG17.",".",".",".",".","."]
["ENSRNOG00000021493",82,5.275095931,23,1.484922772,3.552437898,1.828809429,{"v":3.48442e-09,"d":"3.48E-09"},{"v":3.44718e-09,"d":"3.45E-09"},"up","yes","Prdm9","protein_coding","chr1:56505579-56525652:-","gi|281485597|ref|NP_001102373.2|",4297,0,"histone-lysine N-methyltransferase PRDM9 [Rattus norvegicus]","gi|281485596|ref|NM_001108903.2|",2688,0,"Rattus norvegicus PR domain 9 (Prdm9), mRNA","P0C6Y7",1659,0,"Histone-lysine N-methyltransferase PRDM9",".",".",".",".","pfam09514","SSXRD","SSXRD motif. SSX1 can repress transcription, and this has been attributed to a putative Kruppel associated box (KRAB) repression domain at the N-terminus. However, from the analysis of these deletion constructs further repression activity was found at the C-terminus of SSX1. Which has been called the SSXRD (SSX Repression Domain). The potent repression exerted by full-length SSX1 appears to localize to this region.","GO:0006311|meiotic gene conversion;GO:0007129|synapsis;GO:0007283|spermatogenesis;GO:0007292|female gamete generation;GO:0008150|biological_process;GO:0010468|regulation of gene expression;GO:0010845|positive regulation of reciprocal meiotic recombination;GO:0016571|histone methylation;GO:0016584|nucleosome positioning;GO:0034968|histone lysine methylation;GO:0043066|negative regulation of apoptotic process;GO:0044648|histone H3-K4 dimethylation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048232|male gamete generation;GO:0051567|histone H3-K9 methylation;GO:0051568|histone H3-K4 methylation;GO:0060903|positive regulation of meiosis I;GO:0080182|histone H3-K4 trimethylation;GO:0097198|histone H3-K36 trimethylation;GO:0097676|histone H3-K36 dimethylation;GO:0097692|histone H3-K4 monomethylation;GO:1905437|positive regulation of histone H3-K4 trimethylation;GO:1905516|positive regulation of fertilization;GO:1990918|double-strand break repair involved in meiotic recombination;GO:2001255|positive regulation of histone H3-K36 trimethylation;","GO:0000785|chromatin;GO:0005575|cellular_component;GO:0005634|nucleus;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0003674|molecular_function;GO:0010844|recombination hotspot binding;GO:0018024|histone-lysine N-methyltransferase activity;GO:0042800|histone methyltransferase activity (H3-K4 specific);GO:0042803|protein homodimerization activity;GO:0043565|sequence-specific DNA binding;GO:0046872|metal ion binding;GO:0046975|histone methyltransferase activity (H3-K36 specific);","K20796","PRDM7_9; [histone H3]-lysine4 N-trimethyltransferase PRDM7/9 [EC:2.1.1.354]"]
["ENSRNOG00000067962",195,12.54443545,95,6.133376667,2.045273937,1.032294086,{"v":3.57453e-09,"d":"3.57E-09"},{"v":3.53388e-09,"d":"3.53E-09"},"up","yes","Nat8f3","protein_coding","chr4:118239304-118285500:-","gi|564303970|ref|XP_006225036.1|",913,{"v":1E-108,"d":"1.00E-108"},"PREDICTED: probable N-acetyltransferase CML3 [Rattus norvegicus]","gi|672050325|ref|XM_006236798.2|",3391,0,"PREDICTED: Rattus norvegicus camello-like 3 (Cml3), mRNA","Q9QXS4",356,{"v":3e-110,"d":"3.00E-110"},"N-acetyltransferase family 8 member 3",".",".",".",".","pfam00583","Acetyltransf_1","Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.",".",".",".",".","."]
["ENSRNOG00000004018",76,4.889113302,20,1.291237193,3.78637893,1.920818799,{"v":4.14267e-09,"d":"4.14E-09"},{"v":4.08003e-09,"d":"4.08E-09"},"up","yes","Tdrd5","protein_coding","chr13:68394061-68441319:-","gi|564381186|ref|XP_006250099.1|",4930,0,"PREDICTED: tudor domain-containing protein 5 isoform X1 [Rattus norvegicus]","gi|672074337|ref|XM_008769616.1|",3158,0,"PREDICTED: Rattus norvegicus tudor domain containing 5 (Tdrd5), transcript variant X4, mRNA","B4F7C4",1760,0,"Tudor domain-containing protein 5",".",".",".",".","pfam00567","TUDOR","Tudor domain.","GO:0007286|spermatid development;GO:0030719|P granule organization;GO:0043046|DNA methylation involved in gamete generation;","GO:0005737|cytoplasm;GO:0033391|chromatoid body;GO:0071546|pi-body;",".","K18407","TDRD5; tudor domain-containing protein 5"]
["ENSRNOG00000003221",161,10.35720055,72,4.648453895,2.228095789,1.155811257,{"v":4.14939e-09,"d":"4.15E-09"},{"v":4.08524e-09,"d":"4.09E-09"},"up","yes","Myoc","protein_coding","chr13:74976730-74987127:+","gi|149058242|gb|EDM09399.1|",2612,0,"rCG46529 [Rattus norvegicus]","gi|3845606|dbj|AB019393.1|",2024,0,"Rattus norvegicus mRNA for myocilin, complete cds","Q9R1J4",1006,0,"Myocilin",".",".",".",".","pfam02191","OLF","Olfactomedin-like domain.","GO:0001649|osteoblast differentiation;GO:0001953|negative regulation of cell-matrix adhesion;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0014734|skeletal muscle hypertrophy;GO:0021675|nerve development;GO:0022011|myelination in peripheral nervous system;GO:0030335|positive regulation of cell migration;GO:0031175|neuron projection development;GO:0035024|negative regulation of Rho protein signal transduction;GO:0038031|non-canonical Wnt signaling pathway via JNK cascade;GO:0038133|ERBB2-ERBB3 signaling pathway;GO:0043408|regulation of MAPK cascade;GO:0045162|clustering of voltage-gated sodium channels;GO:0051496|positive regulation of stress fiber assembly;GO:0051497|negative regulation of stress fiber assembly;GO:0051894|positive regulation of focal adhesion assembly;GO:0051897|positive regulation of protein kinase B signaling;GO:0051901|positive regulation of mitochondrial depolarization;GO:0060348|bone development;GO:1900026|positive regulation of substrate adhesion-dependent cell spreading;GO:1990090|cellular response to nerve growth factor stimulus;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005741|mitochondrial outer membrane;GO:0005743|mitochondrial inner membrane;GO:0005758|mitochondrial intermembrane space;GO:0005783|endoplasmic reticulum;GO:0005791|rough endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005929|cilium;GO:0031410|cytoplasmic vesicle;GO:0033268|node of Ranvier;GO:0035748|myelin sheath abaxonal region;GO:0043220|Schmidt-Lanterman incisure;GO:0062023|collagen-containing extracellular matrix;GO:0070062|extracellular exosome;GO:0097453|mesaxon;","GO:0001968|fibronectin binding;GO:0003674|molecular_function;GO:0005109|frizzled binding;GO:0030971|receptor tyrosine kinase binding;GO:0032027|myosin light chain binding;GO:0046872|metal ion binding;","K23027","MYOC; myocilin"]
["ENSRNOG00000025404",51,3.280852347,8,0.516494877,6.352148863,2.667244723,{"v":4.2177e-09,"d":"4.22E-09"},{"v":4.15106e-09,"d":"4.15E-09"},"up","yes","Dppa4","protein_coding","chr11:52570286-52578797:-","gi|293352174|ref|XP_001063552.2|",1224,{"v":3e-163,"d":"3.00E-163"},"PREDICTED: developmental pluripotency-associated protein 4 isoform X1 [Rattus norvegicus]","gi|672026020|ref|XM_003752488.3|",1220,0,"PREDICTED: Rattus norvegicus similar to developmental pluripotency associated 4 isoform 1 (LOC685378), transcript variant X1, mRNA","D3Z8Y2",471,{"v":8e-163,"d":"8.00E-163"},"Developmental pluripotency-associated protein 4",".",".",".",".","pfam14047","DCR","Dppa2/4 conserved region. This domain has been characterized in the finding of a developmental pluripotency associated gene (Dppa) in the lower vertebrate Xenopus laevis. Previous to this discovery, Dppa genes were known only in higher vertebrates. The domain is subject to structure determination by the Joint Center of Structural Genomics.","GO:0048731|system development;GO:0060484|lung-associated mesenchyme development;","GO:0005634|nucleus;","GO:0003682|chromatin binding;",".","."]
["ENSRNOG00000033059",187,12.02979194,90,5.810567369,2.07033,1.049860744,{"v":4.60326e-09,"d":"4.60E-09"},{"v":4.51885E-9,"d":"4.52E-09"},"up","yes","Galnt6","protein_coding","chr7:131789839-131819661:-","gi|285026454|ref|NP_001165534.1|",3274,0,"polypeptide N-acetylgalactosaminyltransferase 6 [Rattus norvegicus]","gi|298892755|emb|FQ211776.1|",3692,0,"Rattus norvegicus TL0AAA80YH07 mRNA sequence","Q8C7U7",1207,0,"Polypeptide N-acetylgalactosaminyltransferase 6",".",".",".",".","pfam00652","Ricin_B_lectin","Ricin-type beta-trefoil lectin domain.","GO:0006486|protein glycosylation;","GO:0000139|Golgi membrane;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;GO:0048471|perinuclear region of cytoplasm;","GO:0004653|polypeptide N-acetylgalactosaminyltransferase activity;GO:0030246|carbohydrate binding;GO:0046872|metal ion binding;","K00710","GALNT; polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41]"]
["ENSRNOG00000023712",85,5.468087246,25,1.614046491,3.387812727,1.760354127,{"v":4.68404e-09,"d":"4.68E-09"},{"v":4.59419e-09,"d":"4.59E-09"},"up","yes","Stox1","protein_coding","chr20:30598168-30666939:-","gi|300795079|ref|NP_001178649.1|",4923,0,"storkhead-box protein 1 [Rattus norvegicus]","gi|300795078|ref|NM_001191720.1|",2937,0,"Rattus norvegicus storkhead box 1 (Stox1), mRNA","B2RQL2",1526,0,"Storkhead-box protein 1",".",".",".",".","pfam10264","Stork_head","Winged helix Storkhead-box1 domain. This is the conserved N-terminal winged helix domain of Storkhead-box1 protein which is likely to be a DNA binding domain. In humans the full-length protein controls polyploidization of extravillus trophoblast and is implicated in pre-eclampsia.","GO:0008150|biological_process;GO:0008284|positive regulation of cell proliferation;GO:0010468|regulation of gene expression;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010800|positive regulation of peptidyl-threonine phosphorylation;GO:0010821|regulation of mitochondrion organization;GO:0010971|positive regulation of G2/M transition of mitotic cell cycle;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0045787|positive regulation of cell cycle;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048839|inner ear development;GO:0050679|positive regulation of epithelial cell proliferation;GO:0051881|regulation of mitochondrial membrane potential;GO:0051897|positive regulation of protein kinase B signaling;GO:0061418|regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0071500|cellular response to nitrosative stress;GO:1901858|regulation of mitochondrial DNA metabolic process;GO:1902882|regulation of response to oxidative stress;GO:1904031|positive regulation of cyclin-dependent protein kinase activity;GO:1904120|positive regulation of otic vesicle morphogenesis;","GO:0001650|fibrillar center;GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0005829|cytosol;GO:0005938|cell cortex;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003674|molecular_function;",".","."]
["ENSRNOG00000002381",43,2.766208842,5,0.322809298,8.569173369,3.09915604,{"v":6.00813E-9,"d":"6.01E-09"},{"v":5.85268e-09,"d":"5.85E-09"},"up","yes","Bmp3","protein_coding","chr14:10712489-10737153:-","gi|149046840|gb|EDL99614.1|",2434,0,"bone morphogenetic protein 3, isoform CRA_b [Rattus norvegicus]","gi|8392992|ref|NM_017105.1|",2140,0,"Rattus norvegicus bone morphogenetic protein 3 (Bmp3), mRNA","P49002",917,0,"Bone morphogenetic protein 3",".",".",".",".","pfam00019","TGF_beta","Transforming growth factor beta like domain.","GO:0001649|osteoblast differentiation;GO:0007165|signal transduction;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051216|cartilage development;GO:0060395|SMAD protein signal transduction;","GO:0005615|extracellular space;GO:0031982|vesicle;","GO:0005125|cytokine activity;GO:0008083|growth factor activity;GO:0070700|BMP receptor binding;","K05496","BMP3; bone morphogenetic protein 3"]
["ENSRNOG00000067461",105,6.754696009,37,2.388788807,2.827665631,1.499611533,{"v":6.52134e-09,"d":"6.52E-09"},{"v":6.3472e-09,"d":"6.35E-09"},"up","yes","Rps12l2","protein_coding","chr1:252597664-252598155:+","gi|823458574|ref|XP_002191710.2|",677,{"v":2E-87,"d":"2.00E-87"},"PREDICTED: 40S ribosomal protein S12 [Taeniopygia guttata]","gi|298911600|emb|FQ222422.1|",483,0,"Rattus norvegicus TL0ADA23YK16 mRNA sequence","P46405",259,{"v":7e-88,"d":"7.00E-88"},"40S ribosomal protein S12","SPCC962.04",151,{"v":1e-45,"d":"1.00E-45"},"COG1358","pfam01248","Ribosomal_L7Ae","Ribosomal protein L7Ae/L30e/S12e/Gadd45 family. This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118.",".",".",".",".","."]
["ENSRNOG00000028767",61,3.924156729,13,0.839304176,4.675488153,2.225117,{"v":7.14907E-9,"d":"7.15E-09"},{"v":6.94161E-9,"d":"6.94E-09"},"up","yes","AABR07001926.1","protein_coding","chr1:62509056-62528102:-","gi|148673829|gb|EDL05776.1|",1795,0,"mCG22919 [Mus musculus]","gi|331028450|ref|NG_028550.1|",676,0,"Mus musculus zinc finger protein 945 pseudogene (LOC100534296) on chromosome 17","Q8TAQ5",398,{"v":6e-127,"d":"6.00E-127"},"Zinc finger protein 420",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000029342",61,3.924156729,13,0.839304176,4.675488153,2.225117,{"v":7.14907E-9,"d":"7.15E-09"},{"v":6.94161E-9,"d":"6.94E-09"},"up","yes","Scn7a","protein_coding","chr3:51335841-51438256:-","gi|564341195|ref|XP_006234358.1|",8480,0,"PREDICTED: sodium channel protein type 7 subunit alpha isoform X1 [Rattus norvegicus]","gi|672045864|ref|XM_006234296.2|",6630,0,"PREDICTED: Rattus norvegicus sodium channel, voltage-gated, type VII, alpha subunit (Scn7a), transcript variant X1, mRNA","Q01118",2394,0,"Sodium channel protein type 7 subunit alpha",".",".",".",".","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0006814|sodium ion transport;GO:0006936|muscle contraction;GO:0009617|response to bacterium;GO:0019228|neuronal action potential;GO:0034765|regulation of ion transmembrane transport;GO:0035725|sodium ion transmembrane transport;GO:0055078|sodium ion homeostasis;GO:0086010|membrane depolarization during action potential;","GO:0001518|voltage-gated sodium channel complex;GO:0005886|plasma membrane;GO:0030424|axon;GO:0097386|glial cell projection;","GO:0005244|voltage-gated ion channel activity;GO:0005248|voltage-gated sodium channel activity;GO:0005272|sodium channel activity;","K04839","SCN7A, SCN6A; voltage-gated sodium channel type VII alpha"]
["ENSRNOG00000012591",31,1.994243584,0,0.03228093,61.7777615,5.949015691,{"v":7.23084e-09,"d":"7.23E-09"},{"v":7.01623e-09,"d":"7.02E-09"},"up","yes","Pkd2l1","protein_coding","chr1:243032913-243070031:-","gi|672040343|ref|XP_008758621.1|",3781,0,"PREDICTED: polycystic kidney disease 2-like 1 protein isoform X1 [Rattus norvegicus]","gi|672040342|ref|XM_008760399.1|",3174,0,"PREDICTED: Rattus norvegicus polycystic kidney disease 2-like 1 (Pkd2l1), transcript variant X1, mRNA","A2A259",1321,0,"Polycystic kidney disease 2-like 1 protein",".",".",".",".","pfam08016","PKD_channel","Polycystin cation channel. This family contains the cation channel region of PKD1 and PKD2 proteins.","GO:0001581|detection of chemical stimulus involved in sensory perception of sour taste;GO:0006812|cation transport;GO:0007224|smoothened signaling pathway;GO:0009415|response to water;GO:0035725|sodium ion transmembrane transport;GO:0050912|detection of chemical stimulus involved in sensory perception of taste;GO:0050915|sensory perception of sour taste;GO:0050982|detection of mechanical stimulus;GO:0051262|protein tetramerization;GO:0051289|protein homotetramerization;GO:0070588|calcium ion transmembrane transport;GO:0071467|cellular response to pH;GO:0071468|cellular response to acidic pH;GO:0071805|potassium ion transmembrane transport;GO:0098662|inorganic cation transmembrane transport;","GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0031410|cytoplasmic vesicle;GO:0034703|cation channel complex;GO:0034704|calcium channel complex;GO:0043231|intracellular membrane-bounded organelle;GO:0043235|receptor complex;GO:0060170|ciliary membrane;GO:0097730|non-motile cilium;","GO:0005227|calcium activated cation channel activity;GO:0005261|cation channel activity;GO:0005262|calcium channel activity;GO:0005272|sodium channel activity;GO:0005509|calcium ion binding;GO:0008092|cytoskeletal protein binding;GO:0008324|cation transmembrane transporter activity;GO:0015269|calcium-activated potassium channel activity;GO:0033040|sour taste receptor activity;GO:0042802|identical protein binding;GO:0051371|muscle alpha-actinin binding;GO:0051393|alpha-actinin binding;","K04990","PKD2L1; polycystin 2L1"]
["ENSRNOG00000009610",45,2.894869718,6,0.387371158,7.47311631,2.901709976,{"v":8.16149e-09,"d":"8.16E-09"},{"v":7.90182e-09,"d":"7.90E-09"},"up","yes","ENSRNOG00000009610","protein_coding","chr2:179135796-179138202:+","gi|149033027|gb|EDL87856.1|",3005,0,"rCG40952 [Rattus norvegicus]","gi|672043340|ref|XR_145852.3|",1777,0,"PREDICTED: Rattus norvegicus trichohyalin-like 1 (Tchhl1), misc_RNA","Q9D3P1",863,0,"Trichohyalin-like protein 1",".",".",".",".","pfam01023","S_100","S-100/ICaBP type calcium binding domain. The S-100 domain is a subfamily of the EF-hand calcium binding proteins.",".",".","GO:0005509|calcium ion binding;GO:0046914|transition metal ion binding;",".","."]
["ENSRNOG00000010634",130,8.362956964,53,3.421778562,2.444038038,1.289266739,{"v":8.55324e-09,"d":"8.55E-09"},{"v":8.26848e-09,"d":"8.27E-09"},"up","yes","Megf11","protein_coding","chr8:64892387-65216061:+","gi|49022876|dbj|BAC65837.2|",5257,0,"mKIAA1781 protein [Mus musculus]","gi|672022931|ref|XM_006226432.2|",3963,0,"PREDICTED: Rattus norvegicus multiple EGF-like-domains 11 (Megf11), transcript variant X1, mRNA","Q80T91",1960,0,"Multiple epidermal growth factor-like domains protein 11",".",".",".",".","pfam07546","EMI","EMI domain. The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.","GO:0010842|retina layer formation;GO:0034109|homotypic cell-cell adhesion;","GO:0016021|integral component of membrane;",".","K24068","MEGF10_11; multiple epidermal growth factor-like domains protein 10/11"]
["ENSRNOG00000014970",87,5.596748122,27,1.743170211,3.210672192,1.682875374,{"v":9.34114e-09,"d":"9.34E-09"},{"v":9.01489e-09,"d":"9.01E-09"},"up","yes","Kif17","protein_coding","chr5:150481578-150519638:+","gi|564353823|ref|XP_006239352.1|",5123,0,"PREDICTED: kinesin-like protein KIF17 isoform X5 [Rattus norvegicus]","gi|672054702|ref|XM_006239290.2|",3185,0,"PREDICTED: Rattus norvegicus kinesin family member 17 (Kif17), transcript variant X1, mRNA","Q99PW8",1831,0,"Kinesin-like protein KIF17","SPAC1834.07",249,{"v":1e-69,"d":"1.00E-69"},"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0007017|microtubule-based process;GO:0007018|microtubule-based movement;GO:0016192|vesicle-mediated transport;GO:0030030|cell projection organization;GO:0031503|protein-containing complex localization;GO:0098971|anterograde dendritic transport of neurotransmitter receptor complex;","GO:0005815|microtubule organizing center;GO:0005871|kinesin complex;GO:0005874|microtubule;GO:0005929|cilium;GO:0005930|axoneme;GO:0015630|microtubule cytoskeleton;GO:0030992|intraciliary transport particle B;GO:0032391|photoreceptor connecting cilium;GO:0032839|dendrite cytoplasm;GO:0036064|ciliary basal body;GO:0043005|neuron projection;GO:1990075|periciliary membrane compartment;","GO:0003777|microtubule motor activity;GO:0005524|ATP binding;GO:0008017|microtubule binding;GO:0008574|ATP-dependent microtubule motor activity, plus-end-directed;GO:0016887|ATPase activity;","K20198","KIF17; kinesin family member 17"]
["ENSRNOG00000009503",177,11.38648756,85,5.487758071,2.074888764,1.053033995,{"v":1.0897E-8,"d":"1.09E-08"},{"v":1.04704e-08,"d":"1.05E-08"},"up","yes","Depdc1","protein_coding","chr2:248684523-248717951:+","gi|762205487|ref|NP_001292134.1|",3978,0,"DEP domain-containing protein 1A [Rattus norvegicus]","gi|762205486|ref|NM_001305205.1|",3327,0,"Rattus norvegicus DEP domain containing 1 (Depdc1), mRNA","Q8CIG0",1403,0,"DEP domain-containing protein 1A",".",".",".",".","pfam00610","DEP","Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP). The DEP domain is responsible for mediating intracellular protein targeting and regulation of protein stability in the cell. The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit.","GO:0035556|intracellular signal transduction;GO:0045892|negative regulation of transcription, DNA-templated;","GO:0005634|nucleus;GO:0017053|transcriptional repressor complex;",".",".","."]
["ENSRNOG00000016717",72,4.631791549,19,1.226675333,3.775890346,1.916816869,{"v":1.1058E-8,"d":"1.11E-08"},{"v":1.06161e-08,"d":"1.06E-08"},"up","yes","Gas2","protein_coding","chr1:101482591-101582619:+","gi|189011542|ref|NP_001120976.1|",1496,0,"growth arrest-specific protein 2 [Rattus norvegicus]","gi|189011541|ref|NM_001127504.1|",2056,0,"Rattus norvegicus growth arrest-specific 2 (Gas2), mRNA","P11862",578,0,"Growth arrest-specific protein 2",".",".",".",".","pfam02187","GAS2","Growth-Arrest-Specific Protein 2 Domain.","GO:0001544|initiation of primordial ovarian follicle growth;GO:0001547|antral ovarian follicle growth;GO:0006915|apoptotic process;GO:0008593|regulation of Notch signaling pathway;GO:0030728|ovulation;GO:0051764|actin crosslink formation;GO:0071711|basement membrane organization;","GO:0005884|actin filament;","GO:0008017|microtubule binding;GO:0008093|cytoskeletal adaptor activity;GO:0051015|actin filament binding;","K24627","GAS2, GAS2L; growth arrest-specific protein 2"]
["ENSRNOG00000031726",66,4.24580892,16,1.032989754,4.11021397,2.0392135,{"v":1.21525e-08,"d":"1.22E-08"},{"v":1.16317E-8,"d":"1.16E-08"},"up","yes","Oas1e","protein_coding","chr12:35750359-35759301:+","gi|57222312|ref|NP_001009492.1|",1941,0,"2'-5' oligoadenylate synthetase 1E [Rattus norvegicus]","gi|57222311|ref|NM_001009492.1|",1667,0,"Rattus norvegicus 2'-5' oligoadenylate synthetase 1E (Oas1e), mRNA","Q8VI95",533,0,"Inactive 2'-5'-oligoadenylate synthase 1D",".",".",".",".","pfam10421","OAS1_C","2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus. This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between 320 and 344 at the extreme C-terminal end. Oligoadenylate synthetases are antiviral enzymes that counteract vial attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesize 2'.5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication. This domain is often associated with NTP_transf_2 pfam01909.","GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0051607|defense response to virus;GO:0060700|regulation of ribonuclease activity;","GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0016020|membrane;","GO:0003725|double-stranded RNA binding;",".","."]
["ENSRNOG00000018785",133,8.555948279,56,3.615464141,2.366486831,1.242746894,{"v":1.52663e-08,"d":"1.53E-08"},{"v":1.45318E-8,"d":"1.45E-08"},"up","yes","Slc16a13","protein_coding","chr10:54926760-54937788:-","gi|53850584|ref|NP_001005530.1|",1511,0,"monocarboxylate transporter 13 [Rattus norvegicus]","gi|53850583|ref|NM_001005530.1|",1367,0,"Rattus norvegicus solute carrier family 16, member 13 (Slc16a13), mRNA","Q66HE2",586,0,"Monocarboxylate transporter 13",".",".",".",".","pfam07690","MFS_1","Major Facilitator Superfamily.","GO:0015718|monocarboxylic acid transport;GO:0055085|transmembrane transport;","GO:0000139|Golgi membrane;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;","GO:0008028|monocarboxylic acid transmembrane transporter activity;GO:0015293|symporter activity;","K08189","SLC16A13; MFS transporter, MCT family, solute carrier family 16 (monocarboxylic acid transporters), member 13"]
["ENSRNOG00000003997",36,2.315895775,3,0.193685579,11.9569861,3.579781881,{"v":1.54776E-8,"d":"1.55E-08"},{"v":1.47207E-8,"d":"1.47E-08"},"up","yes","Pld5","protein_coding","chr13:87896369-88232868:-","gi|880927737|ref|XP_012974586.1|",2786,0,"PREDICTED: inactive phospholipase D5 isoform X1 [Mesocricetus auratus]","gi|300794157|ref|NM_001191674.1|",1531,0,"Rattus norvegicus phospholipase D family, member 5 (Pld5), mRNA","Q3UNN8",956,0,"Inactive phospholipase D5",".",".",".",".","pfam13918","PLDc_3","PLD-like domain.","GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0003824|catalytic activity;","K16861","PLD5; inactive phospholipase D5"]
["ENSRNOG00000069767",75,4.824782864,21,1.355799053,3.558626814,1.831320648,{"v":1.56281e-08,"d":"1.56E-08"},{"v":1.48612e-08,"d":"1.49E-08"},"up","yes","Vom2r6","protein_coding","chr1:1161832-1224262:+","gi|153791928|ref|NP_001092929.1|",4360,0,"vomeronasal 2 receptor 6 precursor [Rattus norvegicus]","gi|153791927|ref|NM_001099459.1|",2526,0,"Rattus norvegicus vomeronasal 2 receptor, 6 (Vom2r6), mRNA","E9Q6I0",809,0,"Vomeronasal type-2 receptor 116",".",".",".",".","pfam02994","Transposase_22","L1 transposable element.",".",".",".",".","."]
["ENSRNOG00000017409",164,10.55019186,77,4.971263193,2.122235627,1.085584845,{"v":1.69657e-08,"d":"1.70E-08"},{"v":1.61011e-08,"d":"1.61E-08"},"up","yes","Wnt6","protein_coding","chr9:76329882-76343523:+","gi|533163811|ref|XP_005395678.1|",1549,0,"PREDICTED: protein Wnt-6 [Chinchilla lanigera]","gi|157822842|ref|NM_001108226.1|",2060,0,"Rattus norvegicus wingless-type MMTV integration site family, member 6 (Wnt6), mRNA","P22727",598,0,"Protein Wnt-6",".",".",".",".","pfam00110","wnt","wnt family. Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.","GO:0001658|branching involved in ureteric bud morphogenesis;GO:0008150|biological_process;GO:0009798|axis specification;GO:0010628|positive regulation of gene expression;GO:0016055|Wnt signaling pathway;GO:0030182|neuron differentiation;GO:0042475|odontogenesis of dentin-containing tooth;GO:0045165|cell fate commitment;GO:0045893|positive regulation of transcription, DNA-templated;GO:0060070|canonical Wnt signaling pathway;GO:0060684|epithelial-mesenchymal cell signaling;GO:0070172|positive regulation of tooth mineralization;GO:0072079|nephron tubule formation;GO:0072080|nephron tubule development;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0009986|cell surface;GO:0031012|extracellular matrix;","GO:0003674|molecular_function;GO:0005109|frizzled binding;GO:0005125|cytokine activity;","K00445","WNT6; wingless-type MMTV integration site family, member 6"]
["ENSRNOG00000001193",61,3.924156729,14,0.903866035,4.341524713,2.118201796,{"v":1.99623E-8,"d":"2.00E-08"},{"v":1.8851e-08,"d":"1.89E-08"},"up","yes","Hsf2bp","protein_coding","chr20:10035562-10121242:-","gi|672086023|ref|XP_008771048.1|",1526,0,"PREDICTED: heat shock factor 2-binding protein isoform X1 [Rattus norvegicus]","gi|189085372|ref|NM_001127683.1|",2766,0,"Rattus norvegicus heat shock transcription factor 2 binding protein (Hsf2bp), mRNA","Q9D4G2",565,0,"Heat shock factor 2-binding protein",".",".",".",".","pfam10100","DUF2338","Uncharacterized protein conserved in bacteria (DUF2338). Members of this family of hypothetical bacterial proteins have no known function.","GO:0007141|male meiosis I;GO:0007144|female meiosis I;GO:0007283|spermatogenesis;GO:1990918|double-strand break repair involved in meiotic recombination;","GO:0005694|chromosome;",".",".","."]
["ENSRNOG00000021269",54,3.473843662,11,0.710180456,4.891494312,2.290275264,{"v":2.99496e-08,"d":"2.99E-08"},{"v":2.79907e-08,"d":"2.80E-08"},"up","yes","Chgb","protein_coding","chr3:120043738-120057166:+","gi|564343142|ref|XP_006235134.1|",2695,0,"PREDICTED: secretogranin-1 isoform X1 [Rattus norvegicus]","gi|672046753|ref|XM_006235072.2|",2226,0,"PREDICTED: Rattus norvegicus chromogranin B (secretogranin 1) (Chgb), transcript variant X1, mRNA","O35314",1040,0,"Secretogranin-1",".",".",".",".","pfam01271","Granin","Granin (chromogranin or secretogranin).",".","GO:0005615|extracellular space;GO:0030141|secretory granule;",".","K19991","CHGB; chromogranin-B"]
["ENSRNOG00000068352",32,2.058574022,2,0.129123719,15.94264813,3.994819381,{"v":3.05943e-08,"d":"3.06E-08"},{"v":2.85652e-08,"d":"2.86E-08"},"up","yes","ENSRNOG00000068352","protein_coding","chr3:9485412-9489543:+","gi|392346165|ref|XP_001060674.3|",574,{"v":2E-70,"d":"2.00E-70"},"PREDICTED: uncharacterized protein LOC681186 isoform X3 [Rattus norvegicus]","gi|672016532|ref|XR_600102.1|",480,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102547612 (LOC102547612), transcript variant X2, ncRNA","Q62472",51.6,1e-06,"Vomeronasal secretory protein 2",".",".",".",".","pfam00061","Lipocalin","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.",".",".",".",".","."]
["ENSRNOG00000004640",134,8.620278717,58,3.74458786,2.302063415,1.202927576,{"v":3.09713e-08,"d":"3.10E-08"},{"v":2.89078e-08,"d":"2.89E-08"},"up","yes","Mtfp1","protein_coding","chr14:78968442-78972274:-","gi|880877024|ref|XP_005068976.2|",912,{"v":4e-117,"d":"4.00E-117"},"PREDICTED: mitochondrial fission process protein 1 [Mesocricetus auratus]","gi|55741521|ref|NM_001006960.1|",1346,0,"Rattus norvegicus mitochondrial fission process 1 (Mtfp1), mRNA","Q9CRB8",317,{"v":2e-105,"d":"2.00E-105"},"Mitochondrial fission process protein 1",".",".",".",".","pfam10558","MTP18","Mitochondrial 18 KDa protein (MTP18). This family of proteins are mitochondrial 18KDa proteins that are often misannotated as carbonic anhydrases. It was shown that knockdown of MTP18 protein results in a cytochrome c release from mitochondria and consequently leads to apoptosis. Overexpression studies suggest that MTP18 is required for mitochondrial fission.","GO:0000266|mitochondrial fission;GO:0006915|apoptotic process;GO:0007005|mitochondrion organization;GO:0014850|response to muscle activity;","GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;","GO:0003674|molecular_function;","K17981","MTFP1, MTP18; mitochondrial fission process protein 1"]
["ENSRNOG00000055769",101,6.497374257,37,2.388788807,2.719945035,1.443577498,{"v":3.16591e-08,"d":"3.17E-08"},{"v":2.95256e-08,"d":"2.95E-08"},"up","yes","AABR07054286.1","protein_coding","chr3:139344037-139365237:-","gi|672017532|ref|XP_008773787.1|",1714,0,"PREDICTED: sperm motility kinase X-like [Rattus norvegicus]","gi|672017537|ref|XR_600409.1|",3631,0,"PREDICTED: Rattus norvegicus similar to serine/threonine kinase (RGD1565143), transcript variant X5, misc_RNA","Q9R0N0",304,{"v":2E-109,"d":"2.00E-109"},"Galactokinase",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.",".",".",".",".","."]
["ENSRNOG00000011672",58,3.731165415,13,0.839304176,4.445546113,2.152360658,{"v":3.23878e-08,"d":"3.24E-08"},{"v":3.01707e-08,"d":"3.02E-08"},"up","yes","Tph1","protein_coding","chr1:97157409-97178344:-","gi|564328425|ref|XP_006229280.1|",2402,0,"PREDICTED: tryptophan 5-hydroxylase 1 isoform X2 [Rattus norvegicus]","gi|257900503|ref|NM_001100634.2|",3892,0,"Rattus norvegicus tryptophan hydroxylase 1 (Tph1), mRNA","P09810",922,0,"Tryptophan 5-hydroxylase 1","RSc3355",127,{"v":2e-30,"d":"2.00E-30"},"COG3186","pfam00351","Biopterin_H","Biopterin-dependent aromatic amino acid hydroxylase. This family includes phenylalanine-4-hydroxylase, the phenylketonuria disease protein.","GO:0002576|platelet degranulation;GO:0006587|serotonin biosynthetic process from tryptophan;GO:0007623|circadian rhythm;GO:0030279|negative regulation of ossification;GO:0035902|response to immobilization stress;GO:0042427|serotonin biosynthetic process;GO:0045600|positive regulation of fat cell differentiation;GO:0046849|bone remodeling;GO:0060749|mammary gland alveolus development;GO:1900046|regulation of hemostasis;","GO:0005737|cytoplasm;GO:0043005|neuron projection;","GO:0004510|tryptophan 5-monooxygenase activity;GO:0005506|iron ion binding;","K00502","TPH1_2; tryptophan 5-monooxygenase [EC:1.14.16.4]"]
["ENSRNOG00000014874",62,3.988487167,15,0.968427895,4.118517433,2.042125095,{"v":3.25166e-08,"d":"3.25E-08"},{"v":3.02858E-8,"d":"3.03E-08"},"up","yes","Zfyve28","protein_coding","chr14:76468424-76554039:+","gi|564384371|ref|XP_006251318.1|",4789,0,"PREDICTED: lateral signaling target protein 2 homolog isoform X1 [Rattus norvegicus]","gi|672076706|ref|XM_006251256.2|",3997,0,"PREDICTED: Rattus norvegicus zinc finger, FYVE domain containing 28 (Zfyve28), transcript variant X1, mRNA","Q6ZPK7",1746,0,"Lateral signaling target protein 2 homolog",".",".",".",".","pfam01363","FYVE","FYVE zinc finger. The FYVE zinc finger is named after four proteins that it has been found in: Fab1, YOTB/ZK632.12, Vac1, and EEA1. The FYVE finger has been shown to bind two Zn++ ions. The FYVE finger has eight potential zinc coordinating cysteine positions. Many members of this family also include two histidines in a motif R+HHC+XCG, where + represents a charged residue and X any residue. We have included members which do not conserve these histidine residues but are clearly related.","GO:0007175|negative regulation of epidermal growth factor-activated receptor activity;GO:0042059|negative regulation of epidermal growth factor receptor signaling pathway;","GO:0005829|cytosol;GO:0031901|early endosome membrane;","GO:0032266|phosphatidylinositol-3-phosphate binding;GO:0046872|metal ion binding;","K24780","ZFYVE28, LST2; lateral signaling target protein 2"]
["ENSRNOG00000039740",109,7.012017762,42,2.711598106,2.585935485,1.370686283,{"v":3.27427e-08,"d":"3.27E-08"},{"v":3.04914E-8,"d":"3.05E-08"},"up","yes","Cenpk","protein_coding","chr2:35360132-35385706:+","gi|157823361|ref|NP_001099877.1|",1580,0,"centromere protein K [Rattus norvegicus]","gi|157823360|ref|NM_001106407.1|",1641,0,"Rattus norvegicus centromere protein K (Cenpk), mRNA","Q9ESN5",311,{"v":3e-100,"d":"3.00E-100"},"Centromere protein K",".",".",".",".","pfam11802","CENP-K","Centromere-associated protein K. CENP-K is one of seven new CENP-A-nucleosome distal (CAD) centromere components (the others being CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S) that are identified as assembling on the CENP-A nucleosome associated complex, NAC. The CENP-A NAC is essential, as disruption of the complex causes errors of chromosome alignment and segregation that preclude cell survival despite continued centromere-derived mitotic checkpoint signalling. CENP-K is centromere-associated through its interaction with one or more components of the CENP-A NAC.","GO:0000070|mitotic sister chromatid segregation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051382|kinetochore assembly;","GO:0000775|chromosome, centromeric region;GO:0005634|nucleus;",".","K11503","CENPK; centromere protein K"]
["ENSRNOG00000033335",159,10.22853967,75,4.842139474,2.112400877,1.078883645,{"v":3.27836e-08,"d":"3.28E-08"},{"v":3.05245e-08,"d":"3.05E-08"},"up","yes","Cenpi","protein_coding","chrX:97515972-97567657:+","gi|564399935|ref|XP_006257277.1|",3685,0,"PREDICTED: centromere protein I isoform X1 [Rattus norvegicus]","gi|672088146|ref|XM_006257215.2|",3165,0,"PREDICTED: Rattus norvegicus centromere protein I (Cenpi), transcript variant X3, mRNA","Q63517",1402,0,"Centromere protein I",".",".",".",".","pfam07778","CENP-I","Mis6. Mis6 is an essential centromere connector protein acting during G1-S phase of the cell cycle. Mis6 is thought to be required for recruiting CENP-A, the centromere- specific histone H3 variant, an important event for centromere function and chromosome segregation during mitosis.","GO:0034508|centromere complex assembly;GO:0042699|follicle-stimulating hormone signaling pathway;","GO:0000776|kinetochore;GO:0005634|nucleus;GO:0005829|cytosol;GO:0016604|nuclear body;",".","K11501","CENPI; centromere protein I"]
["ENSRNOG00000007730",29,1.865582707,1,0.06456186,28.89604973,4.852800376,{"v":3.3989e-08,"d":"3.40E-08"},{"v":3.16108E-8,"d":"3.16E-08"},"up","yes","Vom2r53","protein_coding","chr7:10267390-10300054:+","gi|149034697|gb|EDL89434.1|",4381,0,"rCG29211 [Rattus norvegicus]","gi|31581527|ref|NM_173131.2|",2697,0,"Rattus norvegicus vomeronasal 2 receptor, 53 (Vom2r53), mRNA","E9Q6I0",650,0,"Vomeronasal type-2 receptor 116",".",".",".",".","pfam00003","7tm_3","7 transmembrane sweet-taste receptor of 3 GCPR. This is a domain of seven transmembrane regions that forms the C-terminus of some subclass 3 G-coupled-protein receptors. It is often associated with a downstream cysteine-rich linker domain, NCD3G pfam07562, which is the human sweet-taste receptor, and the N-terminal domain, ANF_receptor pfam01094. The seven TM regions assemble in such a way as to produce a docking pocket into which such molecules as cyclamate and lactisole have been found to bind and consequently confer the taste of sweetness.","GO:0007186|G protein-coupled receptor signaling pathway;","GO:0005887|integral component of plasma membrane;","GO:0004930|G protein-coupled receptor activity;","K04613","V2R; vomeronasal 2 receptor"]
["ENSRNOG00000043199",132,8.49161784,57,3.680026,2.307488545,1.206323486,{"v":3.65712e-08,"d":"3.66E-08"},{"v":3.39515e-08,"d":"3.40E-08"},"up","yes","Bves","protein_coding","chr20:48822308-48857472:+","gi|117606391|ref|NP_001071058.1|",1849,0,"blood vessel epicardial substance [Rattus norvegicus]","gi|117606390|ref|NM_001077590.1|",1471,0,"Rattus norvegicus blood vessel epicardial substance (Bves), mRNA","Q3BCU4",716,0,"Blood vessel epicardial substance",".",".",".",".","pfam04831","Popeye","Popeye protein conserved region. The function of Popeye proteins is not well understood. They are predominantly expressed in cardiac and skeletal muscle. This family represents a conserved region which includes three potential transmembrane domains.","GO:0001921|positive regulation of receptor recycling;GO:0002027|regulation of heart rate;GO:0002244|hematopoietic progenitor cell differentiation;GO:0002931|response to ischemia;GO:0007507|heart development;GO:0007519|skeletal muscle tissue development;GO:0008360|regulation of cell shape;GO:0016192|vesicle-mediated transport;GO:0034446|substrate adhesion-dependent cell spreading;GO:0040017|positive regulation of locomotion;GO:0042391|regulation of membrane potential;GO:0043087|regulation of GTPase activity;GO:0048278|vesicle docking;GO:0051146|striated muscle cell differentiation;GO:0060931|sinoatrial node cell development;GO:0060973|cell migration involved in heart development;GO:0090136|epithelial cell-cell adhesion;GO:2001135|regulation of endocytic recycling;","GO:0005886|plasma membrane;GO:0005901|caveola;GO:0005923|bicellular tight junction;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016328|lateral plasma membrane;GO:0030054|cell junction;GO:0031253|cell projection membrane;GO:0042383|sarcolemma;","GO:0005198|structural molecule activity;GO:0030552|cAMP binding;","K21108","BVES; blood vessel epicardial substance"]
["ENSRNOG00000009073",73,4.696121987,21,1.355799053,3.463730099,1.792326517,{"v":3.86631e-08,"d":"3.87E-08"},{"v":3.58528e-08,"d":"3.59E-08"},"up","yes","Tnni1","protein_coding","chr13:47229216-47241644:+","gi|149058525|gb|EDM09682.1|",865,{"v":4e-113,"d":"4.00E-113"},"troponin I, skeletal, slow 1 [Rattus norvegicus]","gi|672074084|ref|XM_006249865.2|",1048,0,"PREDICTED: Rattus norvegicus troponin I type 1 (skeletal, slow) (Tnni1), transcript variant X3, mRNA","P02645",317,{"v":2e-106,"d":"2.00E-106"},"Troponin I, slow skeletal muscle",".",".",".",".","pfam00992","Troponin","Troponin. Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). this Pfam contains members of the TnT subunit. Troponin is a complex of three proteins, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). The troponin complex regulates Ca++ induced muscle contraction. This family includes troponin T and troponin I. Troponin I binds to actin and troponin T binds to tropomyosin.","GO:0003009|skeletal muscle contraction;GO:0006936|muscle contraction;GO:0006937|regulation of muscle contraction;GO:0014883|transition between fast and slow fiber;GO:0055010|ventricular cardiac muscle tissue morphogenesis;GO:0060048|cardiac muscle contraction;","GO:0005861|troponin complex;","GO:0003779|actin binding;GO:0046872|metal ion binding;","K10371","TNNI1; troponin I, slow skeletal muscle"]
["ENSRNOG00000009863",71,4.567461111,20,1.291237193,3.537275053,1.822638405,{"v":4.16216e-08,"d":"4.16E-08"},{"v":3.85211e-08,"d":"3.85E-08"},"up","yes","Prrt3","protein_coding","chr4:146641173-146650317:-","gi|827475627|ref|NP_001296392.1|",3176,0,"proline-rich transmembrane protein 3 precursor [Rattus norvegicus]","gi|827475626|ref|NM_001309463.1|",4342,0,"Rattus norvegicus proline-rich transmembrane protein 3 (Prrt3), mRNA","Q6PE13",1059,0,"Proline-rich transmembrane protein 3",".",".",".",".","pfam05518","Totivirus_coat","Totivirus coat protein.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000068075",92,5.918400313,32,2.065979509,2.864694585,1.518381337,{"v":4.20909e-08,"d":"4.21E-08"},{"v":3.89365e-08,"d":"3.89E-08"},"up","yes","ENSRNOG00000068075","lncRNA","chr6:14075793-14125737:+",".",".",".",".","gi|74096673|gb|AC163903.4|",882,0,"Mus musculus BAC clone RP24-314J18 from chromosome 17, complete sequence",".",".",".",".",".",".",".",".","pfam09419","PGP_phosphatase","Mitochondrial PGP phosphatase. This is a family of proteins that acts as a mitochondrial phosphatase in cardiolipin biosynthesis. Cardiolipin is a unique dimeric phosphoglycerolipid predominantly present in mitochondrial membranes. The inverted phosphatase motif includes the highly conserved DKD triad.",".",".",".",".","."]
["ENSRNOG00000021555",161,10.35720055,77,4.971263193,2.083414244,1.058949718,{"v":4.33396e-08,"d":"4.33E-08"},{"v":4.00333e-08,"d":"4.00E-08"},"up","yes","Mis18a","protein_coding","chr11:29967701-29981062:-","gi|189230091|ref|NP_001120995.2|",1001,{"v":7e-132,"d":"7.00E-132"},"protein Mis18-alpha [Rattus norvegicus]","gi|189230090|ref|NM_001127523.2|",992,0,"Rattus norvegicus MIS18 kinetochore protein A (Mis18a), mRNA","B2RZC4",390,{"v":2e-133,"d":"2.00E-133"},"Protein Mis18-alpha",".",".",".",".","pfam03226","Yippee-Mis18","Yippee zinc-binding/DNA-binding /Mis18, centromere assembly. This family includes both Yippee-type proteins and Mis18 kinetochore proteins. Yippee are putative zinc-binding/DNA-binding proteins. Mis18 are proteins involved in the priming of centromeres for recruiting CENP-A. Mis18-alpha and beta form part of a small complex with Mis18-binding protein. Mis18-alpha is found to interact with DNA de-methylases through a Leu-rich region located at its carboxyl terminus.","GO:0007059|chromosome segregation;GO:0034080|CENP-A containing nucleosome assembly;GO:0044030|regulation of DNA methylation;GO:0051301|cell division;","GO:0000775|chromosome, centromeric region;GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0042802|identical protein binding;GO:0046872|metal ion binding;","K11564","MIS18, FASP1; kinetochore protein Mis18"]
["ENSRNOG00000019170",51,3.280852347,10,0.645618597,5.081719091,2.345316628,{"v":4.6902e-08,"d":"4.69E-08"},{"v":4.32539e-08,"d":"4.33E-08"},"up","yes","Il27","protein_coding","chr1:181173372-181178582:-","gi|149067881|gb|EDM17433.1|",756,{"v":1E-97,"d":"1.00E-97"},"rCG40370 [Rattus norvegicus]","gi|672014257|ref|XM_002725687.4|",705,0,"PREDICTED: Rattus norvegicus interleukin 27 (Il27), mRNA","Q8K3I6",268,{"v":2e-88,"d":"2.00E-88"},"Interleukin-27 subunit alpha",".",".",".",".","pfam15449","Retinal","Retinal protein. This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.","GO:0002230|positive regulation of defense response to virus by host;GO:0009617|response to bacterium;GO:0032729|positive regulation of interferon-gamma production;GO:0042129|regulation of T cell proliferation;GO:0045625|regulation of T-helper 1 cell differentiation;","GO:0005575|cellular_component;GO:0005615|extracellular space;","GO:0003674|molecular_function;GO:0005102|signaling receptor binding;GO:0045523|interleukin-27 receptor binding;","K22629","IL27, IL27A; interleukin 27 subunit alpha"]
["ENSRNOG00000011332",165,10.6145223,80,5.164948772,2.055106985,1.0392135,{"v":4.77213e-08,"d":"4.77E-08"},{"v":4.3967e-08,"d":"4.40E-08"},"up","yes","Clspn","protein_coding","chr5:138850128-138885034:+","gi|564352826|ref|XP_006238925.1|",5270,0,"PREDICTED: claspin isoform X1 [Rattus norvegicus]","gi|672053671|ref|XM_006238863.2|",5059,0,"PREDICTED: Rattus norvegicus claspin (Clspn), transcript variant X2, mRNA","Q80YR7",1748,0,"Claspin",".",".",".",".","pfam15482","CCER1","Coiled-coil domain-containing glutamate-rich protein family 1. This is a family of coiled-coil family proteins found in eukaryotes. Proteins in this family are typically between 160 and 397 amino acids in length.","GO:0000076|DNA replication checkpoint;GO:0000077|DNA damage checkpoint;GO:0007095|mitotic G2 DNA damage checkpoint;GO:0018105|peptidyl-serine phosphorylation;GO:0032147|activation of protein kinase activity;GO:0033314|mitotic DNA replication checkpoint;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005794|Golgi apparatus;","GO:0000217|DNA secondary structure binding;GO:0010997|anaphase-promoting complex binding;",".","."]
["ENSRNOG00000047860",53,3.409513224,11,0.710180456,4.800911084,2.263308217,{"v":5.01022e-08,"d":"5.01E-08"},{"v":4.60862e-08,"d":"4.61E-08"},"up","yes","Plin5","protein_coding","chr9:939747-946120:-","gi|197385053|ref|NP_001128109.1|",2495,0,"perilipin-5 [Rattus norvegicus]","gi|197385052|ref|NM_001134637.1|",1934,0,"Rattus norvegicus perilipin 5 (Plin5), mRNA","M0R7Z9",965,0,"Perilipin-5",".",".",".",".","pfam03036","Perilipin","Perilipin family. The perilipin family includes lipid droplet-associated protein (perilipin) and adipose differentiation-related protein (adipophilin).","GO:0010867|positive regulation of triglyceride biosynthetic process;GO:0010884|positive regulation of lipid storage;GO:0010890|positive regulation of sequestering of triglyceride;GO:0010897|negative regulation of triglyceride catabolic process;GO:0019915|lipid storage;GO:0031999|negative regulation of fatty acid beta-oxidation;GO:0032000|positive regulation of fatty acid beta-oxidation;GO:0034389|lipid droplet organization;GO:0035359|negative regulation of peroxisome proliferator activated receptor signaling pathway;GO:0050995|negative regulation of lipid catabolic process;GO:0051646|mitochondrion localization;GO:0060192|negative regulation of lipase activity;GO:0060193|positive regulation of lipase activity;GO:2000378|negative regulation of reactive oxygen species metabolic process;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005811|lipid droplet;GO:0005829|cytosol;GO:0043231|intracellular membrane-bounded organelle;","GO:0005515|protein binding;GO:0035473|lipase binding;GO:0042802|identical protein binding;","K20255","PLIN5; perilipin-5"]
["ENSRNOG00000004195",125,8.041304773,53,3.421778562,2.350036575,1.232683211,{"v":5.0145e-08,"d":"5.01E-08"},{"v":4.61181e-08,"d":"4.61E-08"},"up","yes","Dtl","protein_coding","chr13:103117186-103154890:-","gi|564316400|ref|XP_001068900.3|",3322,0,"PREDICTED: denticleless protein homolog isoform X1 [Rattus norvegicus]","gi|564382379|ref|XM_223074.7|",2817,0,"PREDICTED: Rattus norvegicus denticleless E3 ubiquitin protein ligase homolog (Drosophila) (Dtl), transcript variant X1, mRNA","Q3TLR7",1186,0,"Denticleless protein homolog",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.","GO:0000209|protein polyubiquitination;GO:0006511|ubiquitin-dependent protein catabolic process;GO:0006513|protein monoubiquitination;GO:0006974|cellular response to DNA damage stimulus;GO:0007095|mitotic G2 DNA damage checkpoint;GO:0009411|response to UV;GO:0010971|positive regulation of G2/M transition of mitotic cell cycle;GO:0019985|translesion synthesis;GO:0045732|positive regulation of protein catabolic process;GO:0051726|regulation of cell cycle;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005813|centrosome;GO:0005829|cytosol;GO:0031464|Cul4A-RING E3 ubiquitin ligase complex;GO:0031465|Cul4B-RING E3 ubiquitin ligase complex;GO:0080008|Cul4-RING E3 ubiquitin ligase complex;","GO:0004842|ubiquitin-protein transferase activity;","K11790","DTL, CDT2, DCAF2; denticleless"]
["ENSRNOG00000003544",55,3.5381741,12,0.774742316,4.566904412,2.191216593,{"v":5.22282E-8,"d":"5.22E-08"},{"v":4.79876e-08,"d":"4.80E-08"},"up","yes","Tbx4","protein_coding","chr10:70731163-70760825:+","gi|157820223|ref|NP_001100504.1|",2946,0,"T-box transcription factor TBX4 [Rattus norvegicus]","gi|157820222|ref|NM_001107034.1|",3254,0,"Rattus norvegicus T-box 4 (Tbx4), mRNA","P70325",1105,0,"T-box transcription factor TBX4",".",".",".",".","pfam00907","T-box","T-box. The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.","GO:0001525|angiogenesis;GO:0001708|cell fate specification;GO:0002009|morphogenesis of an epithelium;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008150|biological_process;GO:0030324|lung development;GO:0030326|embryonic limb morphogenesis;GO:0035108|limb morphogenesis;GO:0035116|embryonic hindlimb morphogenesis;GO:0048705|skeletal system morphogenesis;GO:1990401|embryonic lung development;","GO:0005575|cellular_component;GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003674|molecular_function;","K10178","TBX4; T-box protein 4"]
["ENSRNOG00000033923",114,7.333669953,46,2.969845544,2.469377563,1.304147439,{"v":5.34483E-8,"d":"5.34E-08"},{"v":4.90456e-08,"d":"4.90E-08"},"up","yes","Aox2","protein_coding","chr9:59828084-59916146:+","gi|672065175|ref|XP_008765328.1|",6863,0,"PREDICTED: aldehyde oxidase 2 isoform X1 [Rattus norvegicus]","gi|672065174|ref|XM_008767106.1|",4403,0,"PREDICTED: Rattus norvegicus aldehyde oxidase 2 (Aox2), transcript variant X1, mRNA","Q5QE78",2608,0,"Aldehyde oxidase 2","SMb21287",476,{"v":3e-147,"d":"3.00E-147"},"COG4631","pfam02738","Ald_Xan_dh_C2","Molybdopterin-binding domain of aldehyde dehydrogenase.","GO:0006805|xenobiotic metabolic process;","GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004031|aldehyde oxidase activity;GO:0005506|iron ion binding;GO:0016491|oxidoreductase activity;GO:0042803|protein homodimerization activity;GO:0043546|molybdopterin cofactor binding;GO:0050250|retinal oxidase activity;GO:0050660|flavin adenine dinucleotide binding;GO:0051287|NAD binding;GO:0051537|2 iron, 2 sulfur cluster binding;GO:0071949|FAD binding;GO:0102797|geranial:oxygen oxidoreductase activity;GO:0102798|heptaldehyde:oxygen oxidoreductase activity;","K00157","AOX; aldehyde oxidase [EC:1.2.3.1]"]
["ENSRNOG00000014003",129,8.298626526,56,3.615464141,2.295314295,1.198691714,{"v":6.07974e-08,"d":"6.08E-08"},{"v":5.55572e-08,"d":"5.56E-08"},"up","yes","Fbxo16","protein_coding","chr15:39492377-39541480:+","gi|61557048|ref|NP_001013150.1|",1556,0,"F-box only protein 16 [Rattus norvegicus]","gi|672078311|ref|XM_006252201.2|",972,0,"PREDICTED: Rattus norvegicus F-box protein 16 (Fbxo16), transcript variant X1, mRNA","Q9QZM9",571,0,"F-box only protein 16",".",".",".",".","pfam12937","F-box-like","F-box-like. This is an F-box-like family.",".",".",".","K10299","FBXO16; F-box protein 16"]
["ENSRNOG00000052665",27,1.736921831,0,0.03228093,53.80643743,5.749706883,{"v":6.59686e-08,"d":"6.60E-08"},{"v":6.01576e-08,"d":"6.02E-08"},"up","yes","Onecut2","protein_coding","chr18:57832111-57879629:+","gi|119220568|ref|NP_919244.2|",2066,0,"one cut domain family member 2 [Mus musculus]","gi|672083727|ref|XM_008772203.1|",2063,0,"PREDICTED: Rattus norvegicus one cut homeobox 2 (Onecut2), transcript variant X2, mRNA","Q6XBJ3",800,0,"One cut domain family member 2",".",".",".",".","pfam02376","CUT","CUT domain. The CUT domain is a DNA-binding motif which can bind independently or in cooperation with the homeodomain, often found downstream of the CUT domain. Multiple copies of the CUT domain can exist in one protein.","GO:0001889|liver development;GO:0001952|regulation of cell-matrix adhesion;GO:0002064|epithelial cell development;GO:0009653|anatomical structure morphogenesis;GO:0030335|positive regulation of cell migration;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0031016|pancreas development;GO:0031018|endocrine pancreas development;GO:0045165|cell fate commitment;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048935|peripheral nervous system neuron development;GO:0060271|cilium assembly;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0015629|actin cytoskeleton;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:1990837|sequence-specific double-stranded DNA binding;","K24170","ONECUT2; one cut domain family member 2"]
["ENSRNOG00000046365",107,6.883356886,42,2.711598106,2.538487127,1.343968944,{"v":6.9153e-08,"d":"6.92E-08"},{"v":6.29911e-08,"d":"6.30E-08"},"up","yes","Oit3","protein_coding","chr20:27390113-27410692:-","gi|48040437|ref|NP_001001507.1|",2907,0,"oncoprotein-induced transcript 3 protein precursor [Rattus norvegicus]","gi|48040436|ref|NM_001001507.1|",2280,0,"Rattus norvegicus oncoprotein induced transcript 3 (Oit3), mRNA","Q6V0K7",1124,0,"Oncoprotein-induced transcript 3 protein",".",".",".",".","pfam00100","Zona_pellucida","Zona pellucida-like domain.","GO:1903118|urate homeostasis;","GO:0005615|extracellular space;GO:0005635|nuclear envelope;GO:0009986|cell surface;","GO:0005201|extracellular matrix structural constituent;GO:0005509|calcium ion binding;GO:0005515|protein binding;","K24431","OPA3; oncoprotein-induced transcript 3 protein"]
["ENSRNOG00000047236",121,7.78398302,51,3.292654842,2.364044637,1.241257276,{"v":6.96165e-08,"d":"6.96E-08"},{"v":6.34032E-8,"d":"6.34E-08"},"up","yes","AABR07008066.2","protein_coding","chr2:41527707-41527895:+","gi|74146039|dbj|BAE24218.1|",275,{"v":3e-30,"d":"3.00E-30"},"unnamed protein product [Mus musculus]","gi|672041403|ref|XM_008760723.1|",189,{"v":4e-93,"d":"4.00E-93"},"PREDICTED: Rattus norvegicus phosphodiesterase 4D, cAMP-specific (Pde4d), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam10271","Tmp39","Putative transmembrane protein. This is a family of conserved proteins found from worms to humans. They are putative transmembrane proteins but the function is unknown.",".",".",".",".","."]
["ENSRNOG00000042787",68,4.374469797,19,1.226675333,3.56611866,1.834354708,{"v":7.03531E-8,"d":"7.04E-08"},{"v":6.40332e-08,"d":"6.40E-08"},"up","yes","Fam229a","protein_coding","chr5:141828664-141830705:+","gi|148230322|ref|NP_001078960.1|",528,{"v":9e-63,"d":"9.00E-63"},"protein FAM229A [Mus musculus]","gi|157824219|ref|NM_001109266.1|",806,0,"Rattus norvegicus family with sequence similarity 229, member A (Fam229a), mRNA",".",".",".",".",".",".",".",".","pfam14982","UPF0731","UPF0731 family. The UPF0731 family of uncharacterized proteins is found in mammals.",".",".",".",".","."]
["ENSRNOG00000023721",110,7.0763482,44,2.840721825,2.49103877,1.316747476,{"v":7.32483e-08,"d":"7.32E-08"},{"v":6.6594e-08,"d":"6.66E-08"},"up","yes","ENSRNOG00000023721","protein_coding","chr3:140872460-140907719:+","gi|564343607|ref|XP_006235308.1|",1839,0,"PREDICTED: uncharacterized protein C20orf96 homolog isoform X1 [Rattus norvegicus]","gi|672017572|ref|XM_002726251.4|",2492,0,"PREDICTED: Rattus norvegicus zinc finger, CCHC domain containing 3 (Zcchc3), mRNA","Q9NUD5",516,{"v":2e-168,"d":"2.00E-168"},"Zinc finger CCHC domain-containing protein 3",".",".",".",".","pfam15397","DUF4618","Domain of unknown function (DUF4618). This family of proteins is found in eukaryotes. Proteins in this family are typically between 238 and 363 amino acids in length. There are two conserved sequence motifs: EYP and KCTPD.",".",".",".",".","."]
["ENSRNOG00000049734",41,2.637547966,6,0.387371158,6.808839305,2.767408885,{"v":7.79636e-08,"d":"7.80E-08"},{"v":7.07346e-08,"d":"7.07E-08"},"up","yes","Slc5a4","protein_coding","chr20:12475644-12518738:-","gi|157823978|ref|NP_001099853.1|",2751,0,"low affinity sodium-glucose cotransporter [Rattus norvegicus]","gi|157823977|ref|NM_001106383.1|",2079,0,"Rattus norvegicus solute carrier family 5 (glucose activated ion channel), member 4 (Slc5a4), mRNA","Q9ET37",951,0,"Solute carrier family 5 member 4A","BH2222",153,{"v":8e-39,"d":"8.00E-39"},"COG4146","pfam00474","SSF","Sodium:solute symporter family. Membership of this family is supported by a significant blast score.","GO:0006814|sodium ion transport;GO:1902600|proton transmembrane transport;GO:1904659|glucose transmembrane transport;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0005412|glucose:sodium symporter activity;GO:0015078|proton transmembrane transporter activity;","K14384","SLC5A4, SGLT3; solute carrier family 5 (low affinity sodium-glucose cotransporter), member 4"]
["ENSRNOG00000010545",108,6.947687324,43,2.776159965,2.502624997,1.323442128,{"v":8.56714e-08,"d":"8.57E-08"},{"v":7.74938e-08,"d":"7.75E-08"},"up","yes","Mrap2","protein_coding","chr8:88088272-88143886:+","gi|157817506|ref|NP_001102244.1|",1108,{"v":2e-148,"d":"2.00E-148"},"melanocortin-2 receptor accessory protein 2 [Rattus norvegicus]","gi|157817505|ref|NM_001108774.1|",1313,0,"Rattus norvegicus melanocortin 2 receptor accessory protein 2 (Mrap2), mRNA","D3Z1Q2",413,{"v":9E-143,"d":"9.00E-143"},"Melanocortin-2 receptor accessory protein 2",".",".",".",".","pfam15183","MRAP","Melanocortin-2 receptor accessory protein family. This family is thought to be involved in cell trafficking. It is required for MC2R expression in certain cell types, suggesting that it is involved in the processing, trafficking or function of MC2R. MRAP may be involved in the intracellular trafficking pathways in adipocyte cells. This family of proteins is found in eukaryotes. Proteins in this family are typically between 47 and 205 amino acids in length.","GO:0006112|energy reserve metabolic process;GO:0007631|feeding behavior;GO:0072659|protein localization to plasma membrane;GO:0097009|energy homeostasis;GO:0106070|regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0106071|positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0106072|negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:1903077|negative regulation of protein localization to plasma membrane;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0030545|receptor regulator activity;GO:0031780|corticotropin hormone receptor binding;GO:0031781|type 3 melanocortin receptor binding;GO:0031782|type 4 melanocortin receptor binding;GO:0031783|type 5 melanocortin receptor binding;GO:0042802|identical protein binding;GO:0070996|type 1 melanocortin receptor binding;",".","."]
["ENSRNOG00000063551",30,1.929913146,2,0.129123719,14.94623262,3.901709976,{"v":1.02433E-7,"d":"1.02E-07"},{"v":9.23048e-08,"d":"9.23E-08"},"up","yes","ENSRNOG00000063551","lncRNA","chr5:70168476-70171183:+","gi|37361874|gb|AAQ91050.1|",125,{"v":2e-11,"d":"2.00E-11"},"LRRGT00094 [Rattus norvegicus]","gi|49457876|gb|AC129700.8|",1588,0,"Rattus norvegicus 4 BAC CH230-10L17 (Children's Hospital Oakland Research Institute) complete sequence","P51517",53.9,7e-06,"Gag-Pro-Pol polyprotein",".",".",".",".","pfam14828","Amnionless","Amnionless. The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.",".",".",".",".","."]
["ENSRNOG00000066903",69,4.438800235,20,1.291237193,3.437633503,1.781415743,{"v":1.0283E-7,"d":"1.03E-07"},{"v":9.26182E-8,"d":"9.26E-08"},"up","yes","ENSRNOG00000066903","lncRNA","chr12:33051678-33053140:-",".",".",".",".","gi|89111957|gb|AC114147.5|",88,{"v":5E-36,"d":"5.00E-36"},"Rattus norvegicus BAC CH230-144F3 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam03063","Prismane","Prismane/CO dehydrogenase family. This family includes both hybrid-cluster proteins and the beta chain of carbon monoxide dehydrogenase. The hybrid-cluster proteins contain two Fe/S centres - a [4Fe-4S] cubane cluster, and a hybrid [4Fe-2S-2O] cluster. The physiological role of this protein is as yet unknown, although a role in nitrate/nitrite respiration has been suggested. The prismane protein from Escherichia coli was shown to contain hydroxylamine reductase activity (NH2OH + 2e + 2 H+ -> NH3 + H2O). This activity is rather low. Hydroxylamine reductase activity was also found in CO-dehydrogenase in which the active site Ni was replaced by Fe. The CO dehydrogenase contains a Ni-3Fe-2S-3O centre.",".",".",".",".","."]
["ENSRNOG00000054458",83,5.339426369,28,1.80773207,2.953660256,1.56250389,{"v":1.05315E-7,"d":"1.05E-07"},{"v":9.47373E-8,"d":"9.47E-08"},"up","yes","Kcnmb4","protein_coding","chr7:52066136-52119278:-","gi|13027406|ref|NP_076450.1|",1062,{"v":9e-142,"d":"9.00E-142"},"calcium-activated potassium channel subunit beta-4 [Rattus norvegicus]","gi|171846555|gb|BC161829.1|",1201,0,"Rattus norvegicus potassium large conductance calcium-activated channel, subfamily M, beta member 4, mRNA (cDNA clone MGC:187309 IMAGE:9033053), complete cds","Q9ESK8",413,{"v":3e-143,"d":"3.00E-143"},"Calcium-activated potassium channel subunit beta-4",".",".",".",".","pfam03185","CaKB","Calcium-activated potassium channel, beta subunit.","GO:0001508|action potential;GO:0005513|detection of calcium ion;GO:0006813|potassium ion transport;GO:0019228|neuronal action potential;GO:0071805|potassium ion transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0008076|voltage-gated potassium channel complex;","GO:0015269|calcium-activated potassium channel activity;GO:0015459|potassium channel regulator activity;","K04941","KCNMB4; potassium large conductance calcium-activated channel subfamily M beta member 4"]
["ENSRNOG00000023101",26,1.672591393,0,0.03228093,51.81360642,5.695259099,{"v":1.15537E-7,"d":"1.16E-07"},{"v":1.0359E-7,"d":"1.04E-07"},"up","yes","AABR07047835.1","protein_coding","chr5:48925362-48927475:+","gi|564348552|ref|XP_006237244.1|",1348,0,"PREDICTED: chondroitin sulfate N-acetylgalactosaminyltransferase 2 isoform X2 [Rattus norvegicus]","gi|672050825|ref|XM_006237182.2|",735,0,"PREDICTED: Rattus norvegicus chondroitin sulfate N-acetylgalactosaminyltransferase 2 (Csgalnact2), transcript variant X2, mRNA","Q8C1F4",507,{"v":3E-176,"d":"3.00E-176"},"Chondroitin sulfate N-acetylgalactosaminyltransferase 2",".",".",".",".","pfam05679","CHGN","Chondroitin N-acetylgalactosaminyltransferase.",".",".",".",".","."]
["ENSRNOG00000067144",152,9.778226604,73,4.713015755,2.074728181,1.052922335,{"v":1.17955E-7,"d":"1.18E-07"},{"v":1.05708E-7,"d":"1.06E-07"},"up","yes","RGD1304870","protein_coding","chr10:73747952-73750403:+","gi|602634398|ref|XP_007424071.1|",372,{"v":2E-41,"d":"2.00E-41"},"PREDICTED: transcription elongation factor B polypeptide 2-like isoform X2 [Python bivittatus]","gi|148539564|ref|NR_003564.1|",179,{"v":7e-87,"d":"7.00E-87"},"Mus musculus predicted gene 15698 (Gm15698), non-coding RNA","P62870",142,{"v":9e-41,"d":"9.00E-41"},"Elongin-B",".",".",".",".","pfam00240","ubiquitin","Ubiquitin family. This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) Nedd8, Elongin B, Rub1, and Parkin. A number of them are thought to carry a distinctive five-residue motif termed the proteasome-interacting motif (PIM), which may have a biologically significant role in protein delivery to proteasomes and recruitment of proteasomes to transcription sites.",".",".",".",".","."]
["ENSRNOG00000037039",65,4.181478482,18,1.162113474,3.598167112,1.847262192,{"v":1.18855E-7,"d":"1.19E-07"},{"v":1.06465e-07,"d":"1.06E-07"},"up","yes","RGD1306186","protein_coding","chr5:156075011-156081591:+","gi|68163415|ref|NP_001020157.1|",2451,0,"uncharacterized protein LOC298621 [Rattus norvegicus]","gi|68163414|ref|NM_001024986.1|",1821,0,"Rattus norvegicus similar to RIKEN cDNA 4930569K13 (RGD1306186), mRNA","Q3UWY1",589,0,"Oogenesin-3",".",".",".",".","pfam12799","LRR_4","Leucine Rich repeats (2 copies). Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.","GO:0008284|positive regulation of cell proliferation;GO:0043066|negative regulation of apoptotic process;GO:0045596|negative regulation of cell differentiation;GO:0045892|negative regulation of transcription, DNA-templated;","GO:0005737|cytoplasm;",".",".","."]
["ENSRNOG00000045679",99,6.36871338,38,2.453350667,2.595924613,1.376248487,{"v":1.27232e-07,"d":"1.27E-07"},{"v":1.13719E-7,"d":"1.14E-07"},"up","yes","Apoa1","protein_coding","chr8:46527144-46529035:+","gi|6978515|ref|NP_036870.1|",1264,{"v":1E-172,"d":"1.00E-172"},"apolipoprotein A-I preproprotein [Rattus norvegicus]","gi|298915444|emb|FQ210161.1|",888,0,"Rattus norvegicus TL0ABA33YH12 mRNA sequence","P04639",491,{"v":5e-174,"d":"5.00E-174"},"Apolipoprotein A-I",".",".",".",".","pfam01442","Apolipoprotein","Apolipoprotein A1/A4/E domain. These proteins contain several 22 residue repeats which form a pair of alpha helices. This family includes: Apolipoprotein A-I. Apolipoprotein A-IV, and Apolipoprotein E.","GO:0001932|regulation of protein phosphorylation;GO:0001935|endothelial cell proliferation;GO:0002719|negative regulation of cytokine production involved in immune response;GO:0006644|phospholipid metabolic process;GO:0006656|phosphatidylcholine biosynthetic process;GO:0006695|cholesterol biosynthetic process;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007229|integrin-mediated signaling pathway;GO:0007584|response to nutrient;GO:0008203|cholesterol metabolic process;GO:0008211|glucocorticoid metabolic process;GO:0009410|response to xenobiotic stimulus;GO:0010804|negative regulation of tumor necrosis factor-mediated signaling pathway;GO:0010873|positive regulation of cholesterol esterification;GO:0010875|positive regulation of cholesterol efflux;GO:0010898|positive regulation of triglyceride catabolic process;GO:0010903|negative regulation of very-low-density lipoprotein particle remodeling;GO:0014012|peripheral nervous system axon regeneration;GO:0015914|phospholipid transport;GO:0018158|protein oxidation;GO:0018206|peptidyl-methionine modification;GO:0019915|lipid storage;GO:0030300|regulation of intestinal cholesterol absorption;GO:0030301|cholesterol transport;GO:0030325|adrenal gland development;GO:0031100|animal organ regeneration;GO:0032489|regulation of Cdc42 protein signal transduction;GO:0032691|negative regulation of interleukin-1 beta production;GO:0033344|cholesterol efflux;GO:0033700|phospholipid efflux;GO:0034115|negative regulation of heterotypic cell-cell adhesion;GO:0034372|very-low-density lipoprotein particle remodeling;GO:0034375|high-density lipoprotein particle remodeling;GO:0034380|high-density lipoprotein particle assembly;GO:0035025|positive regulation of Rho protein signal transduction;GO:0042157|lipoprotein metabolic process;GO:0042158|lipoprotein biosynthetic process;GO:0042632|cholesterol homeostasis;GO:0043534|blood vessel endothelial cell migration;GO:0043627|response to estrogen;GO:0043691|reverse cholesterol transport;GO:0045723|positive regulation of fatty acid biosynthetic process;GO:0046470|phosphatidylcholine metabolic process;GO:0046889|positive regulation of lipid biosynthetic process;GO:0050728|negative regulation of inflammatory response;GO:0050766|positive regulation of phagocytosis;GO:0050821|protein stabilization;GO:0050919|negative chemotaxis;GO:0051006|positive regulation of lipoprotein lipase activity;GO:0051180|vitamin transport;GO:0051345|positive regulation of hydrolase activity;GO:0051346|negative regulation of hydrolase activity;GO:0051496|positive regulation of stress fiber assembly;GO:0055091|phospholipid homeostasis;GO:0060192|negative regulation of lipase activity;GO:0060354|negative regulation of cell adhesion molecule production;GO:0060761|negative regulation of response to cytokine stimulus;GO:0070328|triglyceride homeostasis;GO:0070508|cholesterol import;GO:0120009|intermembrane lipid transfer;GO:1900026|positive regulation of substrate adhesion-dependent cell spreading;GO:1902995|positive regulation of phospholipid efflux;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0009986|cell surface;GO:0030139|endocytic vesicle;GO:0031410|cytoplasmic vesicle;GO:0034361|very-low-density lipoprotein particle;GO:0034362|low-density lipoprotein particle;GO:0034363|intermediate-density lipoprotein particle;GO:0034364|high-density lipoprotein particle;GO:0034365|discoidal high-density lipoprotein particle;GO:0034366|spherical high-density lipoprotein particle;GO:0042627|chylomicron;","GO:0001540|amyloid-beta binding;GO:0005102|signaling receptor binding;GO:0005319|lipid transporter activity;GO:0005515|protein binding;GO:0005543|phospholipid binding;GO:0008035|high-density lipoprotein particle binding;GO:0008289|lipid binding;GO:0015485|cholesterol binding;GO:0019899|enzyme binding;GO:0031072|heat shock protein binding;GO:0031210|phosphatidylcholine binding;GO:0034190|apolipoprotein receptor binding;GO:0034191|apolipoprotein A-I receptor binding;GO:0042802|identical protein binding;GO:0045499|chemorepellent activity;GO:0055102|lipase inhibitor activity;GO:0060228|phosphatidylcholine-sterol O-acyltransferase activator activity;GO:0070653|high-density lipoprotein particle receptor binding;GO:0071813|lipoprotein particle binding;GO:0120020|intermembrane cholesterol transfer activity;","K08757","APOA1; apolipoprotein A-I"]
["ENSRNOG00000066849",40,2.573217527,6,0.387371158,6.642770053,2.731784975,{"v":1.36426e-07,"d":"1.36E-07"},{"v":1.21784E-7,"d":"1.22E-07"},"up","yes","RGD1564748","protein_coding","chrX:4755173-4762467:+","gi|672032027|ref|XP_008756584.1|",7400,0,"PREDICTED: collagen alpha-1(III) chain-like isoform X11 [Rattus norvegicus]","gi|672032009|ref|XM_008758354.1|",3616,0,"PREDICTED: Rattus norvegicus similar to Mortality factor 4-like protein 2 (MORF-related gene X protein) (RGD1564748), transcript variant X2, mRNA","Q4R578",256,{"v":2e-74,"d":"2.00E-74"},"Mortality factor 4-like protein 2",".",".",".",".","pfam05712","MRG","MRG. This family consists of three different eukaryotic proteins (mortality factor 4 (MORF4/MRG15), male-specific lethal 3(MSL-3) and ESA1-associated factor 3(EAF3)). It is thought that the MRG family is involved in transcriptional regulation via histone acetylation. It contains 2 chromo domains and a leucine zipper motif.",".",".",".",".","."]
["ENSRNOG00000019864",134,8.620278717,61,3.938273439,2.188847181,1.130171234,{"v":1.38656e-07,"d":"1.39E-07"},{"v":1.23735e-07,"d":"1.24E-07"},"up","yes","C1qtnf12","protein_coding","chr5:166551628-166556003:+","gi|157819319|ref|NP_001101470.1|",1341,0,"protein FAM132A precursor [Rattus norvegicus]","gi|157819318|ref|NM_001108000.1|",1313,0,"Rattus norvegicus family with sequence similarity 132, member A (Fam132a), mRNA","Q8R2Z0",480,{"v":2E-167,"d":"2.00E-167"},"Adipolin",".",".",".",".","pfam00229","TNF","TNF(tumor Necrosis Factor) family.","GO:0007165|signal transduction;GO:0010906|regulation of glucose metabolic process;GO:0035774|positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0045721|negative regulation of gluconeogenesis;GO:0046324|regulation of glucose import;GO:0046326|positive regulation of glucose import;GO:0046628|positive regulation of insulin receptor signaling pathway;GO:0050728|negative regulation of inflammatory response;GO:0051897|positive regulation of protein kinase B signaling;","GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0005179|hormone activity;","K21410","C1QTNF12, FAM132A; adipolin"]
["ENSRNOG00000037082",51,3.280852347,11,0.710180456,4.619744628,2.207813104,{"v":1.39122e-07,"d":"1.39E-07"},{"v":1.24132e-07,"d":"1.24E-07"},"up","yes","Mybphl","protein_coding","chr2:196005325-196018824:+","gi|62078815|ref|NP_001014064.1|",1842,0,"myosin-binding protein H-like [Rattus norvegicus]","gi|62078814|ref|NM_001014042.1|",1306,0,"Rattus norvegicus myosin binding protein H-like (Mybphl), mRNA","Q5PQM4",714,0,"Myosin-binding protein H-like",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0001701|in utero embryonic development;","GO:0030017|sarcomere;GO:0036379|myofilament;",".","K24494","MYBPH; myosin-binding protein H"]
["ENSRNOG00000052887",68,4.374469797,20,1.291237193,3.387812727,1.760354127,{"v":1.60946e-07,"d":"1.61E-07"},{"v":1.42868e-07,"d":"1.43E-07"},"up","yes","Dnajc6","protein_coding","chr5:116119676-116283448:+","gi|564351832|ref|XP_006238508.1|",4387,0,"PREDICTED: putative tyrosine-protein phosphatase auxilin isoform X1 [Rattus norvegicus]","gi|672053166|ref|XM_006238448.2|",4959,0,"PREDICTED: Rattus norvegicus DnaJ (Hsp40) homolog, subfamily C, member 6 (Dnajc6), transcript variant X3, mRNA","Q80TZ3",1673,0,"Putative tyrosine-protein phosphatase auxilin",".",".",".",".","pfam10409","PTEN_C2","C2 domain of PTEN tumor-suppressor protein. This is the C2 domain-like domain, in greek key form, of the PTEN protein, phosphatidyl-inositol triphosphate phosphatase, and it is the C-terminus. This domain may well include a CBR3 loop which means it plays a central role in membrane binding. This domain associates across an extensive interface with the N-terminal phosphatase domain DSPc (pfam00782) suggesting that the C2 domain productively positions the catalytic part of the protein onto the membrane.","GO:0008150|biological_process;GO:0016191|synaptic vesicle uncoating;GO:0016311|dephosphorylation;GO:0072318|clathrin coat disassembly;GO:2000369|regulation of clathrin-dependent endocytosis;","GO:0005575|cellular_component;GO:0014069|postsynaptic density;GO:0045202|synapse;GO:0098793|presynapse;","GO:0003674|molecular_function;GO:0016791|phosphatase activity;","K09526","DNAJC6; DnaJ homolog subfamily C member 6"]
["ENSRNOG00000065770",121,7.78398302,53,3.421778562,2.274835405,1.185762163,{"v":1.98373E-7,"d":"1.98E-07"},{"v":1.74625e-07,"d":"1.75E-07"},"up","yes","Rmi2","protein_coding","chr10:4830553-4837235:-","gi|62655636|ref|XP_573037.1|",692,{"v":1E-83,"d":"1.00E-83"},"PREDICTED: recQ-mediated genome instability protein 2 [Rattus norvegicus]","gi|672024491|ref|XM_001078307.3|",2038,0,"PREDICTED: Rattus norvegicus RecQ mediated genome instability 2 (Rmi2), transcript variant X1, mRNA","Q3UPE3",249,{"v":4e-77,"d":"4.00E-77"},"RecQ-mediated genome instability protein 2",".",".",".",".","pfam07111","HCR","Alpha helical coiled-coil rod protein (HCR). This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.",".",".",".",".","."]
["ENSRNOG00000001451",62,3.988487167,17,1.097551614,3.63398597,1.86155285,{"v":2.00661E-7,"d":"2.01E-07"},{"v":1.76585e-07,"d":"1.77E-07"},"up","yes","Fkbp6","protein_coding","chr12:21319568-21390350:+","gi|564378858|ref|XP_006249193.1|",1541,0,"PREDICTED: inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform X2 [Rattus norvegicus]","gi|672072630|ref|XM_006249131.2|",1387,0,"PREDICTED: Rattus norvegicus FK506 binding protein 6 (Fkbp6), transcript variant X1, mRNA","Q91XW8",573,0,"Inactive peptidyl-prolyl cis-trans isomerase FKBP6","DR1839",72.4,{"v":5e-14,"d":"5.00E-14"},"COG0545","pfam00254","FKBP_C","FKBP-type peptidyl-prolyl cis-trans isomerase.","GO:0006457|protein folding;GO:0007283|spermatogenesis;GO:0030154|cell differentiation;GO:0031047|gene silencing by RNA;GO:0034587|piRNA metabolic process;GO:0043046|DNA methylation involved in gamete generation;GO:0045070|positive regulation of viral genome replication;GO:0051321|meiotic cell cycle;","GO:0000795|synaptonemal complex;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0042802|identical protein binding;GO:0051879|Hsp90 protein binding;","K09572","FKBP6; FK506-binding protein 6 [EC:5.2.1.8]"]
["ENSRNOG00000063398",46,2.959200157,9,0.581056737,5.092790374,2.348456335,{"v":2.07927e-07,"d":"2.08E-07"},{"v":1.82698e-07,"d":"1.83E-07"},"up","yes","Nat8","protein_coding","chr4:118270954-118281763:-","gi|12018332|ref|NP_072157.1|",976,{"v":2E-116,"d":"2.00E-116"},"N-acetyltransferase 8 [Rattus norvegicus]","gi|746817484|ref|NR_130141.1|",1450,0,"Rattus norvegicus uncharacterized LOC100910827 (LOC100910827), long non-coding RNA","Q9QXT3",380,{"v":5e-118,"d":"5.00E-118"},"N-acetyltransferase 8",".",".",".",".","pfam00583","Acetyltransf_1","Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.",".",".",".",".","."]
["ENSRNOG00000047928",50,3.216521909,11,0.710180456,4.5291614,2.179243952,{"v":2.30877e-07,"d":"2.31E-07"},{"v":2.02055e-07,"d":"2.02E-07"},"up","yes","AABR07048653.1","protein_coding","chr5:84280919-84281822:-","gi|16758928|ref|NP_446460.1|",439,{"v":2E-50,"d":"2.00E-50"},"regulator of cell cycle RGCC [Rattus norvegicus]","gi|16758927|ref|NM_054008.1|",834,0,"Rattus norvegicus regulator of cell cycle (Rgcc), mRNA","Q9Z2P4",173,{"v":6E-52,"d":"6.00E-52"},"Regulator of cell cycle RGCC",".",".",".",".","pfam15151","RGCC","Response gene to complement 32 protein family. This family of proteins is found in eukaryotes. Proteins in this family are typically between 44 and 130 amino acids in length. There is a conserved KLGDT sequence motif.",".",".",".",".","."]
["ENSRNOG00000037160",151,9.713896166,74,4.777577614,2.033226239,1.023770754,{"v":2.48246e-07,"d":"2.48E-07"},{"v":2.16857e-07,"d":"2.17E-07"},"up","yes","Bloc1s6","lncRNA","chr3:109816366-109828308:+","gi|9790039|ref|NP_062762.1|",348,{"v":3e-58,"d":"3.00E-58"},"biogenesis of lysosome-related organelles complex 1 subunit 6 [Mus musculus]","gi|71043867|ref|NM_001025714.1|",2074,0,"Rattus norvegicus biogenesis of lysosomal organelles complex 1 subunit 6 (Bloc1s6), mRNA","Q9R0C0",138,{"v":1E-59,"d":"1.00E-59"},"Biogenesis of lysosome-related organelles complex 1 subunit 6",".",".",".",".","pfam14712","Snapin_Pallidin","Snapin/Pallidin. This family of proteins includes Snapin, this protein is associated with the SNARE complex, which mediates synaptic vesicle docking and fusion. It also includes the yeast snapin-like protein SNN1, which is a part of a complex involved in endosomal cargo sorting. The family also includes pallidin, a component of a complex involved in biogenesis of lysosome-related organelles.","GO:0007596|blood coagulation;GO:0008089|anterograde axonal transport;GO:0030318|melanocyte differentiation;GO:0031175|neuron projection development;GO:0032402|melanosome transport;GO:0032816|positive regulation of natural killer cell activation;GO:0033299|secretion of lysosomal enzymes;GO:0035646|endosome to melanosome transport;GO:0043473|pigmentation;GO:0046907|intracellular transport;GO:0048490|anterograde synaptic vesicle transport;GO:0050942|positive regulation of pigment cell differentiation;GO:0061025|membrane fusion;","GO:0005737|cytoplasm;GO:0005768|endosome;GO:0019898|extrinsic component of membrane;GO:0030133|transport vesicle;GO:0031083|BLOC-1 complex;GO:1904115|axon cytoplasm;","GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0051015|actin filament binding;","K20188","BLOC1S6; biogenesis of lysosome-related organelles complex 1 subunit 6"]
["ENSRNOG00000069359",74,4.760452426,24,1.549484632,3.07228115,1.619310246,{"v":2.57294E-7,"d":"2.57E-07"},{"v":2.24486e-07,"d":"2.24E-07"},"up","yes","ENSRNOG00000069359","lncRNA","chr1:14671111-14673538:-","gi|148695124|gb|EDL27071.1|",271,{"v":3E-24,"d":"3.00E-24"},"mCG12966 [Mus musculus]","gi|22204781|emb|AL831793.4|",221,{"v":7e-110,"d":"7.00E-110"},"Mouse DNA sequence from clone RP23-9F23 on chromosome 4, complete sequence",".",".",".",".",".",".",".",".","pfam09997","DUF2238","Predicted membrane protein (DUF2238). This domain, found in various hypothetical bacterial proteins, has no known function.",".",".",".",".","."]
["ENSRNOG00000062931",142,9.134922222,68,4.390206457,2.080750031,1.057103659,{"v":2.80576e-07,"d":"2.81E-07"},{"v":2.44124E-7,"d":"2.44E-07"},"up","yes","ENSRNOG00000062931","protein_coding","chr7:7602683-7651352:+","gi|251823941|ref|NP_001156535.1|",1996,0,"zinc finger protein 878 [Rattus norvegicus]","gi|672057882|ref|XR_355238.2|",1127,0,"PREDICTED: Rattus norvegicus zinc finger protein 709-like 1 (Zfp709l1), transcript variant X1, misc_RNA","E9QAG8",495,{"v":7e-161,"d":"7.00E-161"},"Zinc finger protein 431",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000037124",103,6.626035133,42,2.711598106,2.443590412,1.289002485,{"v":2.99533e-07,"d":"3.00E-07"},{"v":2.60029e-07,"d":"2.60E-07"},"up","yes","Fam227b","protein_coding","chr3:113233205-113392320:-","gi|158341649|ref|NP_001013942.2|",2923,0,"protein FAM227B [Rattus norvegicus]","gi|158341648|ref|NM_001013920.2|",1820,0,"Rattus norvegicus family with sequence similarity 227, member B (Fam227b), mRNA",".",".",".",".",".",".",".",".","pfam14922","FWWh","Protein of unknown function. This is a family of eukaryotic proteins. Most members carry a highly distinctive, conserved sequence motif of FWWh, where h represents a hydrophobic residue. The function of the family is not known.",".",".",".",".","."]
["ENSRNOG00000059045",61,3.924156729,17,1.097551614,3.575373293,1.838093877,{"v":3.18115e-07,"d":"3.18E-07"},{"v":2.75364E-7,"d":"2.75E-07"},"up","yes","AABR07071195.2","snoRNA","chr8:96789997-96790154:-",".",".",".",".","gi|672060403|ref|XR_593658.1|",89,{"v":1e-37,"d":"1.00E-37"},"PREDICTED: Rattus norvegicus uncharacterized LOC102549144 (LOC102549144), transcript variant X4, ncRNA",".",".",".",".",".",".",".",".","pfam00475","IGPD","Imidazoleglycerol-phosphate dehydratase.",".",".",".",".","."]
["ENSRNOG00000004120",112,7.205009077,48,3.098969263,2.324969519,1.217211802,{"v":3.24738e-07,"d":"3.25E-07"},{"v":2.808e-07,"d":"2.81E-07"},"up","yes","ENSRNOG00000004120","protein_coding","chrX:30739413-30740613:+","gi|157818255|ref|NP_001101725.1|",1150,{"v":1e-154,"d":"1.00E-154"},"E3 ubiquitin-protein ligase RNF138-like [Rattus norvegicus]","gi|478733056|ref|NM_001108255.2|",1073,0,"Rattus norvegicus similar to RIKEN cDNA 1700045I19 (RGD1565844), mRNA","Q32LN5",355,{"v":5e-120,"d":"5.00E-120"},"E3 ubiquitin-protein ligase RNF138",".",".",".",".","pfam13923","zf-C3HC4_2","Zinc finger, C3HC4 type (RING finger).","GO:0000724|double-strand break repair via homologous recombination;GO:0008150|biological_process;GO:0010792|DNA double-strand break processing involved in repair via single-strand annealing;GO:0016567|protein ubiquitination;","GO:0005575|cellular_component;GO:0035861|site of double-strand break;","GO:0003674|molecular_function;GO:0003697|single-stranded DNA binding;GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;","K10668","RNF138; E3 ubiquitin-protein ligase RNF138 [EC:2.3.2.27]"]
["ENSRNOG00000068502",115,7.398000391,50,3.228092983,2.291755668,1.196453242,{"v":3.28156e-07,"d":"3.28E-07"},{"v":2.83711e-07,"d":"2.84E-07"},"up","yes","ENSRNOG00000068502","lncRNA","chr11:29981120-29989348:+",".",".",".",".","gi|34368620|gb|AC094784.13|",2850,0,"Rattus norvegicus 11 BAC CH230-4O6 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam07773","DUF1619","Protein of unknown function (DUF1619). This is a family of sequences derived from hypothetical eukaryotic proteins. The region in question is approximately 330 residues long and has a cysteine rich amino-terminus.",".",".",".",".","."]
["ENSRNOG00000007256",68,4.374469797,21,1.355799053,3.226488312,1.689964799,{"v":3.54686E-7,"d":"3.55E-07"},{"v":3.05631e-07,"d":"3.06E-07"},"up","yes","Necab1","protein_coding","chr5:28330206-28357152:+","gi|755505878|ref|XP_011248190.1|",624,{"v":7e-73,"d":"7.00E-73"},"PREDICTED: uncharacterized protein C8orf88 homolog isoform X2 [Mus musculus]","gi|295054745|gb|AC109757.5|",1873,0,"Rattus norvegicus BAC CH230-218I7 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P0DMB2",209,{"v":7e-62,"d":"7.00E-62"},"Uncharacterized protein C8orf88",".",".",".",".","pfam03585","Herpes_ICP4_C","Herpesvirus ICP4-like protein C-terminal region. The immediate-early protein ICP4 (infected-cell polypeptide 4) is required for efficient transcription of early and late viral genes and is thus essential for productive infection. ICP4 is a large phosphoprotein that binds DNA in a sequence specific manner as a homodimer. ICP4 represses transcription from LAT, ICP4 and ORF-P that have high-affinity a ICP4 binding site that spans the transcription initiation site. ICP4 proteins have two highly conserved regions, this family contains the C-terminal region that probably acts as an enhancer for the N-terminal region.","GO:0001835|blastocyst hatching;GO:0042984|regulation of amyloid precursor protein biosynthetic process;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0005509|calcium ion binding;GO:0042802|identical protein binding;","K23854","NECAB; N-terminal EF-hand calcium-binding protein"]
["ENSRNOG00000017027",25,1.608260955,1,0.06456186,24.9103877,4.63867557,{"v":3.69925E-7,"d":"3.70E-07"},{"v":3.18522e-07,"d":"3.19E-07"},"up","yes","Adam2","protein_coding","chr15:40242783-40283952:-","gi|149030319|gb|EDL85375.1|",3744,0,"a disintegrin and metalloprotease domain 2 [Rattus norvegicus]","gi|9910119|ref|NM_020077.1|",2409,0,"Rattus norvegicus ADAM metallopeptidase domain 2 (Adam2), mRNA","Q63202",1439,0,"Disintegrin and metalloproteinase domain-containing protein 2",".",".",".",".","pfam01421","Reprolysin","Reprolysin (M12B) family zinc metalloprotease. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as human ADAM8 and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.","GO:0006508|proteolysis;GO:0007155|cell adhesion;GO:0007229|integrin-mediated signaling pathway;GO:0007283|spermatogenesis;GO:0007338|single fertilization;GO:0007339|binding of sperm to zona pellucida;GO:0008542|visual learning;GO:0008584|male gonad development;GO:0010628|positive regulation of gene expression;GO:0030534|adult behavior;","GO:0001669|acrosomal vesicle;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0032991|protein-containing complex;","GO:0003674|molecular_function;GO:0004222|metalloendopeptidase activity;","K06833","ADAM2; disintegrin and metalloproteinase domain-containing protein 2 [EC:3.4.24.-]"]
["ENSRNOG00000017510",51,3.280852347,12,0.774742316,4.234765909,2.082282222,{"v":3.85061e-07,"d":"3.85E-07"},{"v":3.30956e-07,"d":"3.31E-07"},"up","yes","Mfge8","protein_coding","chr1:133064665-133080073:-","gi|93277126|ref|NP_001035276.1|",2309,0,"lactadherin isoform 1 precursor [Rattus norvegicus]","gi|403310694|ref|NM_001040186.2|",2150,0,"Rattus norvegicus milk fat globule-EGF factor 8 protein (Mfge8), transcript variant 1, mRNA","P21956",824,0,"Lactadherin",".",".",".",".","pfam00754","F5_F8_type_C","F5/8 type C domain. This domain is also known as the discoidin (DS) domain family.","GO:0001525|angiogenesis;GO:0006910|phagocytosis, recognition;GO:0006911|phagocytosis, engulfment;GO:0007155|cell adhesion;GO:0007338|single fertilization;GO:0008284|positive regulation of cell proliferation;GO:0043277|apoptotic cell clearance;GO:0043627|response to estrogen;GO:0050766|positive regulation of phagocytosis;","GO:0002080|acrosomal membrane;GO:0005615|extracellular space;GO:0009897|external side of plasma membrane;GO:0019897|extrinsic component of plasma membrane;","GO:0001786|phosphatidylserine binding;GO:0005178|integrin binding;GO:0008429|phosphatidylethanolamine binding;","K17253","MFGE8; lactadherin"]
["ENSRNOG00000015799",142,9.134922222,69,4.454768316,2.050594234,1.036042043,{"v":4.36926e-07,"d":"4.37E-07"},{"v":3.74182e-07,"d":"3.74E-07"},"up","yes","Nat8f1","protein_coding","chr4:118332862-118344035:-","gi|564347547|ref|XP_006236850.1|",1111,{"v":9e-139,"d":"9.00E-139"},"PREDICTED: probable N-acetyltransferase CML1 isoform X1 [Rattus norvegicus]","gi|227498777|ref|NM_021668.3|",2152,0,"Rattus norvegicus N-acetyltransferase 8 (GCN5-related) family member 1 (Nat8f1), mRNA","Q9QXT4",386,{"v":2e-123,"d":"2.00E-123"},"Probable N-acetyltransferase CML1",".",".",".",".","pfam00583","Acetyltransf_1","Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.","GO:0001702|gastrulation with mouth forming second;","GO:0016021|integral component of membrane;","GO:0008080|N-acetyltransferase activity;","K20838","NAT8; N-acetyltransferase 8 [EC:2.3.1.80 2.3.1.-]"]
["ENSRNOG00000002167",97,6.240052504,39,2.517912527,2.478264212,1.309330004,{"v":4.83069e-07,"d":"4.83E-07"},{"v":4.12523e-07,"d":"4.13E-07"},"up","yes","Dmp1","protein_coding","chr14:5528431-5539323:-","gi|672075644|ref|XP_008768216.1|",1015,{"v":9e-123,"d":"9.00E-123"},"PREDICTED: dentin matrix acidic phosphoprotein 1 isoform X1 [Rattus norvegicus]","gi|672075645|ref|XM_006250622.2|",2774,0,"PREDICTED: Rattus norvegicus dentin matrix acidic phosphoprotein 1 (Dmp1), transcript variant X2, mRNA","P98193",359,{"v":1e-111,"d":"1.00E-111"},"Dentin matrix acidic phosphoprotein 1",".",".",".",".","pfam07263","DMP1","Dentin matrix protein 1 (DMP1). This family consists of several mammalian dentin matrix protein 1 (DMP1) sequences. The dentin matrix acidic phosphoprotein 1 (DMP1) gene has been mapped to human chromosome 4q21. DMP1 is a bone and teeth specific protein initially identified from mineralised dentin. DMP1 is primarily localized in the nuclear compartment of undifferentiated osteoblasts. In the nucleus, DMP1 acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the early phase of osteoblast maturation, Ca(2+) surges into the nucleus from the cytoplasm, triggering the phosphorylation of DMP1 by a nuclear isoform of casein kinase II. This phosphorylated DMP1 is then exported out into the extracellular matrix, where it regulates nucleation of hydroxyapatite. DMP1 is a unique molecule that initiates osteoblast differentiation by transcription in the nucleus and orchestrates mineralised matrix formation extracellularly, at later stages of osteoblast maturation. The DMP1 gene has been found to be ectopically expressed in lung cancer although the reason for this is unknown.","GO:0001503|ossification;GO:0010811|positive regulation of cell-substrate adhesion;GO:0030198|extracellular matrix organization;GO:0030500|regulation of bone mineralization;GO:0031214|biomineral tissue development;GO:0070173|regulation of enamel mineralization;","GO:0005576|extracellular region;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0031012|extracellular matrix;","GO:0030544|Hsp70 protein binding;GO:0050840|extracellular matrix binding;","K23328","DMP1; dentin matrix acidic phosphoprotein 1"]
["ENSRNOG00000068600",69,4.438800235,22,1.420360912,3.125121366,1.643912219,{"v":4.92262e-07,"d":"4.92E-07"},{"v":4.2006e-07,"d":"4.20E-07"},"up","yes","ENSRNOG00000068600","protein_coding","chr2:136282917-136284328:+","gi|578808863|ref|XP_006714189.1|",1047,{"v":5e-142,"d":"5.00E-142"},"PREDICTED: eukaryotic translation initiation factor 4E isoform X1 [Homo sapiens]","gi|672044159|ref|XM_008761488.1|",573,0,"PREDICTED: Rattus norvegicus eukaryotic translation initiation factor 4E (Eif4e), transcript variant X1, mRNA","P63074",405,{"v":3e-143,"d":"3.00E-143"},"Eukaryotic translation initiation factor 4E","SPAC16E8.15",137,{"v":1e-38,"d":"1.00E-38"},"COG5053","pfam01652","IF4E","Eukaryotic initiation factor 4E.",".",".",".",".","."]
["ENSRNOG00000023847",103,6.626035133,43,2.776159965,2.386762728,1.255055153,{"v":5.21484e-07,"d":"5.21E-07"},{"v":4.44067E-7,"d":"4.44E-07"},"up","yes","Nlrp14","protein_coding","chr1:161061165-161089222:+","gi|149068415|gb|EDM17967.1|",4986,0,"rCG39476, isoform CRA_b [Rattus norvegicus]","gi|672014120|ref|XM_001072321.4|",3228,0,"PREDICTED: Rattus norvegicus NLR family, pyrin domain containing 14 (Nlrp14), transcript variant X1, mRNA","Q6B966",1573,0,"NACHT, LRR and PYD domains-containing protein 14",".",".",".",".","pfam05729","NACHT","NACHT domain. This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.","GO:0007283|spermatogenesis;",".",".","K22666","NLRP14, NALP14; NACHT, LRR and PYD domains-containing protein 14"]
["ENSRNOG00000000386",79,5.082104617,28,1.80773207,2.811315183,1.491245207,{"v":5.37196e-07,"d":"5.37E-07"},{"v":4.56901E-7,"d":"4.57E-07"},"up","yes","Pbld1","protein_coding","chr20:25551275-25565614:-","gi|51491893|ref|NP_612539.2|",1541,0,"phenazine biosynthesis-like domain-containing protein [Rattus norvegicus]","gi|672086121|ref|XM_006256372.2|",1985,0,"PREDICTED: Rattus norvegicus phenazine biosynthesis-like protein domain containing 1 (Pbld1), transcript variant X1, mRNA","Q68G31",598,0,"Phenazine biosynthesis-like domain-containing protein","PA2770",178,{"v":6e-50,"d":"6.00E-50"},"COG0384","pfam02567","PhzC-PhzF","Phenazine biosynthesis-like protein. PhzC/PhzF is involved in dimerization of two 2,3-dihydro-3-oxo-anthranilic acid molecules to create PCA by P. fluorescens. This family also contains an uncharacterized protein Rv2715 from Mycobacterium tuberculosis, though there is no significant sequence similarity to pfam00303 members. This family appears to be distantly related to pfam01678, including containing a weak internal duplication. However members of this family do not contain the conserved cysteines that are hypothesised to be active site residues (Bateman A pers obs).","GO:0009058|biosynthetic process;GO:0030277|maintenance of gastrointestinal epithelium;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0060392|negative regulation of SMAD protein signal transduction;","GO:0005737|cytoplasm;","GO:0016853|isomerase activity;GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000003562",144,9.263583099,71,4.583892036,2.020899058,1.014997263,{"v":5.66078E-7,"d":"5.66E-07"},{"v":4.80893e-07,"d":"4.81E-07"},"up","yes","Susd4","protein_coding","chr13:94455165-94577750:+","gi|221040808|dbj|BAH12105.1|",1777,0,"unnamed protein product [Homo sapiens]","gi|672075061|ref|XM_006250375.2|",2391,0,"PREDICTED: Rattus norvegicus sushi domain containing 4 (Susd4), transcript variant X6, mRNA","Q8BH32",666,0,"Sushi domain-containing protein 4",".",".",".",".","pfam00084","Sushi","Sushi domain (SCR repeat).","GO:0030449|regulation of complement activation;GO:0045957|negative regulation of complement activation, alternative pathway;GO:0045959|negative regulation of complement activation, classical pathway;","GO:0016021|integral component of membrane;",".","K23822","SUSD4; sushi domain-containing protein 4"]
["ENSRNOG00000017246",35,2.251565336,5,0.322809298,6.974908556,2.802174303,{"v":5.87301E-7,"d":"5.87E-07"},{"v":4.97812e-07,"d":"4.98E-07"},"up","yes","Adad1","protein_coding","chr2:119948926-120005913:+","gi|564336241|ref|XP_006232340.1|",2998,0,"PREDICTED: adenosine deaminase domain-containing protein 1 isoform X1 [Rattus norvegicus]","gi|672042074|ref|XM_006232278.2|",2037,0,"PREDICTED: Rattus norvegicus adenosine deaminase domain containing 1 (testis specific) (Adad1), transcript variant X1, mRNA","Q3KR54",1119,0,"Adenosine deaminase domain-containing protein 1",".",".",".",".","pfam02137","A_deamin","Adenosine-deaminase (editase) domain. Adenosine deaminases acting on RNA (ADARs) can deaminate adenosine to form inosine. In long double-stranded RNA, this process is non-specific; it occurs site-specifically in RNA transcripts. The former is important in defence against viruses, whereas the latter may affect splicing or untranslated regions. They are primarily nuclear proteins, but a longer isoform of ADAR1 is found predominantly in the cytoplasm. ADARs are derived from the Tad1-like tRNA deaminases that are present across eukaryotes. These in turn belong to the nucleotide/nucleic acid deaminase superfamily and are characterized by a distinct insert between the two conserved cysteines that are involved in binding zinc.","GO:0006382|adenosine to inosine editing;GO:0006396|RNA processing;GO:0007286|spermatid development;","GO:0005634|nucleus;GO:0005730|nucleolus;GO:0005737|cytoplasm;","GO:0003723|RNA binding;GO:0003725|double-stranded RNA binding;GO:0003726|double-stranded RNA adenosine deaminase activity;GO:0004000|adenosine deaminase activity;GO:0008251|tRNA-specific adenosine deaminase activity;",".","."]
["ENSRNOG00000036675",98,6.304382942,40,2.582474386,2.441217995,1.28760113,{"v":5.92612e-07,"d":"5.93E-07"},{"v":5.0224e-07,"d":"5.02E-07"},"up","yes","Btbd16","protein_coding","chr1:185335725-185389517:+","gi|62945284|ref|NP_001017464.1|",2734,0,"BTB/POZ domain-containing protein 16 [Rattus norvegicus]","gi|402744057|ref|NM_001017464.2|",1845,0,"Rattus norvegicus BTB domain containing 16 (Btbd16), mRNA","Q6AXU1",1057,0,"BTB/POZ domain-containing protein 16",".",".",".",".","pfam04361","DUF494","Protein of unknown function (DUF494). Members of this family of uncharacterized proteins are often named Smg.",".",".",".","K10487","BTBD16; BTB/POZ domain-containing protein 16"]
["ENSRNOG00000014907",24,1.543930516,1,0.06456186,23.91397219,4.579781881,{"v":6.75397e-07,"d":"6.75E-07"},{"v":5.69022e-07,"d":"5.69E-07"},"up","yes","Aldh8a1","protein_coding","chr1:16183940-16203385:+","gi|564324672|ref|XP_006227736.1|",2532,0,"PREDICTED: aldehyde dehydrogenase family 8 member A1 isoform X1 [Rattus norvegicus]","gi|672033831|ref|XM_006227674.2|",1660,0,"PREDICTED: Rattus norvegicus aldehyde dehydrogenase 8 family, member A1 (Aldh8a1), transcript variant X1, mRNA","Q8BH00",916,0,"Aldehyde dehydrogenase family 8 member A1","STM1102",382,{"v":4E-125,"d":"4.00E-125"},"COG1012","pfam00171","Aldedh","Aldehyde dehydrogenase family. This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:1.2.1.3. Succinate-semialdehyde dehydrogenase EC:1.2.1.16. Lactaldehyde dehydrogenase EC:1.2.1.22. Benzaldehyde dehydrogenase EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase EC: 1.5.1.12. Acetaldehyde dehydrogenase EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase EC:1.2.1.41. This family also includes omega crystallin, an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.","GO:0042573|retinoic acid metabolic process;GO:0042574|retinal metabolic process;GO:0042904|9-cis-retinoic acid biosynthetic process;",".","GO:0001758|retinal dehydrogenase activity;GO:0016620|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor;","K23234","ALDH8A1; aminomuconate-semialdehyde dehydrogenase [EC:1.2.1.32]"]
["ENSRNOG00000018039",24,1.543930516,1,0.06456186,23.91397219,4.579781881,{"v":6.75397e-07,"d":"6.75E-07"},{"v":5.69022e-07,"d":"5.69E-07"},"up","yes","Sncb","protein_coding","chr17:9846802-9855012:+","gi|970705124|ref|XP_015090439.1|",475,{"v":1E-53,"d":"1.00E-53"},"PREDICTED: beta-synuclein [Vicugna pacos]","gi|672081072|ref|XM_006253594.2|",1114,0,"PREDICTED: Rattus norvegicus synuclein, beta (Sncb), transcript variant X1, mRNA","P33567",181,{"v":3e-53,"d":"3.00E-53"},"Beta-synuclein",".",".",".",".","pfam01387","Synuclein","Synuclein. There are three types of synucleins in humans, these are called alpha, beta and gamma. Alpha synuclein has been found mutated in families with autosomal dominant Parkinson's disease. A peptide of alpha synuclein has also been found in amyloid plaques in Alzheimer's patients.","GO:0007268|chemical synaptic transmission;GO:0042417|dopamine metabolic process;GO:0043524|negative regulation of neuron apoptotic process;GO:0048488|synaptic vesicle endocytosis;GO:0050808|synapse organization;GO:1901214|regulation of neuron death;","GO:0005737|cytoplasm;GO:0016234|inclusion body;GO:0030426|growth cone;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0043679|axon terminus;GO:0045202|synapse;GO:0098793|presynapse;GO:0099523|presynaptic cytosol;","GO:0005509|calcium ion binding;GO:0043014|alpha-tubulin binding;GO:0046914|transition metal ion binding;GO:0048487|beta-tubulin binding;GO:1903136|cuprous ion binding;","K24201","SNCB; beta-synuclein"]
["ENSRNOG00000031391",24,1.543930516,1,0.06456186,23.91397219,4.579781881,{"v":6.75397e-07,"d":"6.75E-07"},{"v":5.69022e-07,"d":"5.69E-07"},"up","yes","Ceacam16","protein_coding","chr1:79514975-79524871:-","gi|391738042|sp|D3ZQE1.1|CEA16_RAT",2072,0,"RecName: Full=Carcinoembryonic antigen-related cell adhesion molecule 16; Flags: Precursor","gi|281371399|ref|NM_001169579.1|",1615,0,"Rattus norvegicus carcinoembryonic antigen-related cell adhesion molecule 16 (Ceacam16), mRNA","D3ZQE1",802,0,"Carcinoembryonic antigen-related cell adhesion molecule 16",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0007605|sensory perception of sound;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0032426|stereocilium tip;","GO:0003674|molecular_function;GO:0042802|identical protein binding;","K06499","CEACAM, CD66; carcinoembryonic antigen-related cell adhesion molecule"]
["ENSRNOG00000025823",123,7.912643897,57,3.680026,2.15015978,1.104443872,{"v":7.29397e-07,"d":"7.29E-07"},{"v":6.13251e-07,"d":"6.13E-07"},"up","yes","Rbm46","protein_coding","chr2:168198463-168242011:-","gi|344239872|gb|EGV95975.1|",2445,0,"putative RNA-binding protein 46 [Cricetulus griseus]","gi|111038158|gb|AC105842.5|",3470,0,"Rattus norvegicus Renin BAC CH230-29P15 () complete sequence","P86049",941,0,"Probable RNA-binding protein 46",".",".",".",".","pfam14709","DND1_DSRM","double strand RNA binding domain from DEAD END PROTEIN 1. A C-terminal domain in human dead end protein 1 (DND1_HUMAN) homologous to double strand RNA binding domains (PF00035, PF00333)","GO:0001829|trophectodermal cell differentiation;GO:0048255|mRNA stabilization;","GO:0005634|nucleus;","GO:0003723|RNA binding;GO:0003729|mRNA binding;","K25082","RBM46; RNA-binding protein 46"]
["ENSRNOG00000066755",51,3.280852347,13,0.839304176,3.909014685,1.966805004,{"v":1.0002E-6,"d":"1.00E-06"},{"v":8.32719e-07,"d":"8.33E-07"},"up","yes","ENSRNOG00000066755","protein_coding","chr6:16144204-16145608:+","gi|589935503|ref|XP_006980523.1|",1567,0,"PREDICTED: heterogeneous nuclear ribonucleoprotein F-like [Peromyscus maniculatus bairdii]","gi|672055185|ref|XR_354487.2|",712,0,"PREDICTED: Rattus norvegicus similar to heterogeneous nuclear ribonucleoprotein F (LOC679604), transcript variant X2, misc_RNA","Q794E4",607,0,"Heterogeneous nuclear ribonucleoprotein F",".",".",".",".","pfam14259","RRM_6","RNA recognition motif (a.k.a. RRM, RBD, or RNP domain).",".",".",".",".","."]
["ENSRNOG00000005955",110,7.0763482,49,3.163531123,2.23685114,1.16146925,{"v":1.0732e-06,"d":"1.07E-06"},{"v":8.90443E-7,"d":"8.90E-07"},"up","yes","Naalad2","protein_coding","chr8:15407043-15479714:-","gi|157818601|ref|NP_001100272.1|",4212,0,"N-acetylated-alpha-linked acidic dipeptidase 2 [Rattus norvegicus]","gi|157818600|ref|NM_001106802.1|",2993,0,"Rattus norvegicus N-acetylated alpha-linked acidic dipeptidase 2 (Naalad2), mRNA","Q9CZR2",1479,0,"N-acetylated-alpha-linked acidic dipeptidase 2",".",".",".",".","pfam04253","TFR_dimer","Transferrin receptor-like dimerization domain. This domain is involved in dimerization of the transferrin receptor as shown in its crystal structure.","GO:0006508|proteolysis;GO:0042135|neurotransmitter catabolic process;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004180|carboxypeptidase activity;GO:0008233|peptidase activity;GO:0008235|metalloexopeptidase activity;GO:0050129|N-formylglutamate deformylase activity;","K01301","NAALAD; N-acetylated-alpha-linked acidic dipeptidase [EC:3.4.17.21]"]
["ENSRNOG00000001434",126,8.105635211,60,3.873711579,2.092472567,1.065208709,{"v":1.12563e-06,"d":"1.13E-06"},{"v":9.31581e-07,"d":"9.32E-07"},"up","yes","Zp3","protein_coding","chr12:20690547-20697513:-","gi|119850984|gb|AAI27489.1|",2095,0,"Zona pellucida glycoprotein 3 (sperm receptor) [Rattus norvegicus]","gi|119850983|gb|BC127488.1|",1320,0,"Rattus norvegicus zona pellucida glycoprotein 3 (sperm receptor), mRNA (cDNA clone MGC:156611 IMAGE:7308805), complete cds","P97708",805,0,"Zona pellucida sperm-binding protein 3",".",".",".",".","pfam00100","Zona_pellucida","Zona pellucida-like domain.","GO:0001809|positive regulation of type IV hypersensitivity;GO:0001825|blastocyst formation;GO:0002455|humoral immune response mediated by circulating immunoglobulin;GO:0002687|positive regulation of leukocyte migration;GO:0002922|positive regulation of humoral immune response;GO:0007165|signal transduction;GO:0007339|binding of sperm to zona pellucida;GO:0010469|regulation of signaling receptor activity;GO:0032729|positive regulation of interferon-gamma production;GO:0032753|positive regulation of interleukin-4 production;GO:0035803|egg coat formation;GO:0042102|positive regulation of T cell proliferation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0048599|oocyte development;GO:0050729|positive regulation of inflammatory response;GO:2000344|positive regulation of acrosome reaction;GO:2000360|negative regulation of binding of sperm to zona pellucida;GO:2000368|positive regulation of acrosomal vesicle exocytosis;GO:2000386|positive regulation of ovarian follicle development;GO:2000388|positive regulation of antral ovarian follicle growth;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0031012|extracellular matrix;GO:0035805|egg coat;GO:0062023|collagen-containing extracellular matrix;","GO:0030246|carbohydrate binding;GO:0032190|acrosin binding;GO:0035804|structural constituent of egg coat;GO:0042802|identical protein binding;GO:0048018|receptor ligand activity;","K19928","ZP3; zona pellucida sperm-binding protein 3"]
["ENSRNOG00000033844",123,7.912643897,58,3.74458786,2.11308806,1.079352891,{"v":1.16247e-06,"d":"1.16E-06"},{"v":9.61506e-07,"d":"9.62E-07"},"up","yes","Bex1","protein_coding","chrX:99219014-99220958:-","gi|82654212|ref|NP_001032442.1|",575,{"v":4E-70,"d":"4.00E-70"},"protein BEX1 [Rattus norvegicus]","gi|672036837|ref|XM_006229316.2|",762,0,"PREDICTED: Rattus norvegicus protein BEX1-like (LOC100912195), mRNA","Q3MKQ2",213,{"v":1e-66,"d":"1.00E-66"},"Protein BEX1",".",".",".",".","pfam04538","BEX","Brain expressed X-linked like family. This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.","GO:0002052|positive regulation of neuroblast proliferation;GO:0007165|signal transduction;GO:0031103|axon regeneration;GO:0045665|negative regulation of neuron differentiation;GO:0048011|neurotrophin TRK receptor signaling pathway;GO:0061564|axon development;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0005102|signaling receptor binding;GO:0005515|protein binding;",".","."]
["ENSRNOG00000005116",133,8.555948279,65,4.196520878,2.038819424,1.027734003,{"v":1.1907e-06,"d":"1.19E-06"},{"v":9.83863e-07,"d":"9.84E-07"},"up","yes","ENSRNOG00000005116","pseudogene","chr3:141273822-141274716:+","gi|2920825|gb|AAC04621.1|",791,{"v":4e-132,"d":"4.00E-132"},"ribosomal protein S2 [Rattus norvegicus]","gi|2920828|gb|U92698.1|RNU92698",795,0,"Rattus norvegicus ribosomal protein S2 mRNA, complete cds","P27952",310,{"v":2e-130,"d":"2.00E-130"},"40S ribosomal protein S2","SPCC576.08c",190,{"v":3e-82,"d":"3.00E-82"},"COG0098","pfam03719","Ribosomal_S5_C","Ribosomal protein S5, C-terminal domain.",".",".",".",".","."]
["ENSRNOG00000032895",23,1.479600078,1,0.06456186,22.91755668,4.518381337,{"v":1.23573e-06,"d":"1.24E-06"},{"v":1.01989e-06,"d":"1.02E-06"},"up","yes","Cyp4f4","protein_coding","chr7:11717208-11733506:+","gi|27465575|ref|NP_775146.1|",2462,0,"cytochrome P450 4F4 [Rattus norvegicus]","gi|27465574|ref|NM_173123.1|",1549,0,"Rattus norvegicus cytochrome P450, family 4, subfamily f, polypeptide 4 (Cyp4f4), mRNA","P51869",951,0,"Cytochrome P450 4F4","AGc2890",147,{"v":4e-37,"d":"4.00E-37"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0019369|arachidonic acid metabolic process;GO:0036101|leukotriene B4 catabolic process;GO:0042361|menaquinone catabolic process;GO:0042376|phylloquinone catabolic process;GO:0042377|vitamin K catabolic process;GO:0097267|omega-hydroxylase P450 pathway;GO:1905344|prostaglandin catabolic process;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0005506|iron ion binding;GO:0008391|arachidonic acid monooxygenase activity;GO:0020037|heme binding;GO:0050051|leukotriene-B4 20-monooxygenase activity;","K00490","CYP4F; cytochrome P450 family 4 subfamily F [EC:1.14.14.1]"]
["ENSRNOG00000047368",23,1.479600078,1,0.06456186,22.91755668,4.518381337,{"v":1.23573e-06,"d":"1.24E-06"},{"v":1.01989e-06,"d":"1.02E-06"},"up","yes","Acer1","protein_coding","chr9:1793139-1824434:-","gi|157822473|ref|NP_001100345.1|",1454,0,"alkaline ceramidase 1 [Rattus norvegicus]","gi|157822472|ref|NM_001106875.1|",2328,0,"Rattus norvegicus alkaline ceramidase 1 (Acer1), mRNA","Q8R4X1",524,{"v":4e-180,"d":"4.00E-180"},"Alkaline ceramidase 1",".",".",".",".","pfam05875","Ceramidase","Ceramidase. This family consists of several ceramidases. Ceramidases are enzymes involved in regulating cellular levels of ceramides, sphingoid bases, and their phosphates, EC:3.5.1.23.","GO:0006665|sphingolipid metabolic process;GO:0008544|epidermis development;GO:0010446|response to alkaline pH;GO:0019216|regulation of lipid metabolic process;GO:0030148|sphingolipid biosynthetic process;GO:0030154|cell differentiation;GO:0030216|keratinocyte differentiation;GO:0033561|regulation of water loss via skin;GO:0046512|sphingosine biosynthetic process;GO:0046514|ceramide catabolic process;GO:0048733|sebaceous gland development;GO:0071277|cellular response to calcium ion;","GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;","GO:0017040|N-acylsphingosine amidohydrolase activity;GO:0071633|dihydroceramidase activity;GO:0102121|ceramidase activity;","K01441","ACER1_2, ASAH3; alkaline ceramidase [EC:3.5.1.23]"]
["ENSRNOG00000032300",36,2.315895775,6,0.387371158,5.978493048,2.579781881,{"v":1.251E-6,"d":"1.25E-06"},{"v":1.03219E-6,"d":"1.03E-06"},"up","yes","Rpl39l","protein_coding","chr10:5454559-5462029:-","gi|655886300|ref|XP_008246941.1|",255,{"v":4e-23,"d":"4.00E-23"},"PREDICTED: 60S ribosomal protein L39 [Oryctolagus cuniculus]","gi|306922344|ref|NM_001195471.1|",508,0,"Rattus norvegicus ribosomal protein L39-like (Rpl39l), mRNA","Q90YS9",90.9,{"v":1e-20,"d":"1.00E-20"},"60S ribosomal protein L39","SPCC663.04",68.9,{"v":2e-13,"d":"2.00E-13"},"COG2167","pfam00832","Ribosomal_L39","Ribosomal L39 protein.","GO:0006412|translation;GO:0007283|spermatogenesis;","GO:0022625|cytosolic large ribosomal subunit;","GO:0003735|structural constituent of ribosome;","K02924","RP-L39e, RPL39; large subunit ribosomal protein L39e"]
["ENSRNOG00000013532",134,8.620278717,66,4.261082737,2.023025425,1.016514452,{"v":1.35464E-6,"d":"1.35E-06"},{"v":1.11432E-6,"d":"1.11E-06"},"up","yes","Pgam2","protein_coding","chr14:80681776-80683940:-","gi|8393948|ref|NP_059024.1|",1356,0,"phosphoglycerate mutase 2 [Rattus norvegicus]","gi|298883338|emb|FQ217291.1|",829,0,"Rattus norvegicus TL0ACA30YD11 mRNA sequence","P16290",526,0,"Phosphoglycerate mutase 2","RSc0353",295,{"v":3E-98,"d":"3.00E-98"},"COG0588","pfam00300","His_Phos_1","Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centres on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.","GO:0006094|gluconeogenesis;GO:0006096|glycolytic process;GO:0006941|striated muscle contraction;GO:0007219|Notch signaling pathway;GO:0007283|spermatogenesis;GO:0010035|response to inorganic substance;GO:0046689|response to mercury ion;","GO:0005634|nucleus;GO:0005829|cytosol;","GO:0004082|bisphosphoglycerate mutase activity;GO:0004619|phosphoglycerate mutase activity;GO:0016787|hydrolase activity;GO:0042802|identical protein binding;GO:0046538|2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity;","K01834","PGAM, gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]"]
["ENSRNOG00000012593",31,1.994243584,4,0.258247439,7.722220187,2.949015691,{"v":1.41209e-06,"d":"1.41E-06"},{"v":1.15974e-06,"d":"1.16E-06"},"up","yes","Mmel1","protein_coding","chr5:165431343-165461716:+","gi|157819215|ref|NP_001101467.1|",4134,0,"membrane metallo-endopeptidase-like 1 [Rattus norvegicus]","gi|157819214|ref|NM_001107997.1|",2806,0,"Rattus norvegicus membrane metallo-endopeptidase-like 1 (Mmel1), mRNA","P0C1T0",1584,0,"Membrane metallo-endopeptidase-like 1","MA2001",323,{"v":1e-96,"d":"1.00E-96"},"COG3590","pfam05649","Peptidase_M13_N","Peptidase family M13. M13 peptidases are well-studied proteases found in a wide range of organisms including mammals and bacteria. In mammals they participate in processes such as cardiovascular development, blood-pressure regulation, nervous control of respiration, and regulation of the function of neuropeptides in the central nervous system. In bacteria they may be used for digestion of milk.","GO:0006508|proteolysis;GO:0008150|biological_process;GO:0016485|protein processing;","GO:0005615|extracellular space;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0004175|endopeptidase activity;GO:0004222|metalloendopeptidase activity;GO:0008270|zinc ion binding;GO:0046872|metal ion binding;","K08635","MMEL1, NEP; neprilysin [EC:3.4.24.11]"]
["ENSRNOG00000007495",68,4.374469797,23,1.484922772,2.945924111,1.558720266,{"v":1.5522e-06,"d":"1.55E-06"},{"v":1.27153E-6,"d":"1.27E-06"},"up","yes","ENSRNOG00000007495","protein_coding","chrX:37234294-37276708:-","gi|16758124|ref|NP_445847.1|",366,{"v":5e-41,"d":"5.00E-41"},"small muscular protein [Rattus norvegicus]","gi|672087512|ref|XM_006256945.2|",654,0,"PREDICTED: Rattus norvegicus small muscle protein, X-linked (Smpx), transcript variant X1, mRNA","Q925F0",145,{"v":2e-42,"d":"2.00E-42"},"Small muscular protein",".",".",".",".","pfam15355","Chisel","Stretch-responsive small skeletal muscle X protein, Chisel. The murine X-linked gene Chisel (Csl/Smpx) is selectively expressed in cardiac and skeletal muscle cells. It localizes to the costameric cytoskeleton of muscle cells through its association with focal adhesion proteins, where it may participate in regulating the dynamics of actin through the Rac1/p38 kinase pathway. Thus it is implicated in the maintenance of muscle integrity and in responses to biomechanical stress.",".","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005927|muscle tendon junction;GO:0031430|M band;GO:0043034|costamere;GO:0043292|contractile fiber;",".","K24209","SMPX; small muscular protein"]
["ENSRNOG00000059837",122,7.848313459,58,3.74458786,2.095908482,1.067575723,{"v":1.59399E-6,"d":"1.59E-06"},{"v":1.30389e-06,"d":"1.30E-06"},"up","yes","Cdkn2a","protein_coding","chr5:103984949-104003149:-","gi|13928746|ref|NP_113738.1|",574,{"v":2E-70,"d":"2.00E-70"},"cyclin-dependent kinase inhibitor 2A [Rattus norvegicus]","gi|18644699|gb|AF474974.1|",701,0,"Rattus norvegicus strain ACI/SegHsd cyclin-dependent kinase inhibitor 2a p19Arf (Cdkn2a) mRNA, complete cds","Q9R0Z3",225,{"v":6e-72,"d":"6.00E-72"},"Cyclin-dependent kinase inhibitor 2A",".",".",".",".","pfam07392","P19Arf_N","Cyclin-dependent kinase inhibitor 2a p19Arf N-terminus. This family represents the N-terminus (approximately 50 residues) of cyclin-dependent kinase inhibitor 2a p19Arf, which seems to be restricted to mammals. This is a tumor-suppressor protein that has been shown to inhibit the growth of human tumor cells lacking functional p53 by inducing a transient G2 arrest and subsequently apoptosis.","GO:0000079|regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0000082|G1/S transition of mitotic cell cycle;GO:0000209|protein polyubiquitination;GO:0000422|autophagy of mitochondrion;GO:0001953|negative regulation of cell-matrix adhesion;GO:0006364|rRNA processing;GO:0006469|negative regulation of protein kinase activity;GO:0006915|apoptotic process;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007265|Ras protein signal transduction;GO:0007568|aging;GO:0007569|cell aging;GO:0008285|negative regulation of cell proliferation;GO:0008544|epidermis development;GO:0008637|apoptotic mitochondrial changes;GO:0009303|rRNA transcription;GO:0009410|response to xenobiotic stimulus;GO:0009651|response to salt stress;GO:0010033|response to organic substance;GO:0010243|response to organonitrogen compound;GO:0010389|regulation of G2/M transition of mitotic cell cycle;GO:0010468|regulation of gene expression;GO:0010628|positive regulation of gene expression;GO:0014070|response to organic cyclic compound;GO:0021549|cerebellum development;GO:0022008|neurogenesis;GO:0030308|negative regulation of cell growth;GO:0030889|negative regulation of B cell proliferation;GO:0031647|regulation of protein stability;GO:0031648|protein destabilization;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0032091|negative regulation of protein binding;GO:0033088|negative regulation of immature T cell proliferation in thymus;GO:0033235|positive regulation of protein sumoylation;GO:0033600|negative regulation of mammary gland epithelial cell proliferation;GO:0034393|positive regulation of smooth muscle cell apoptotic process;GO:0035019|somatic stem cell population maintenance;GO:0042326|negative regulation of phosphorylation;GO:0042593|glucose homeostasis;GO:0043065|positive regulation of apoptotic process;GO:0043517|positive regulation of DNA damage response, signal transduction by p53 class mediator;GO:0045736|negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045786|negative regulation of cell cycle;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046822|regulation of nucleocytoplasmic transport;GO:0046825|regulation of protein export from nucleus;GO:0048103|somatic stem cell division;GO:0050821|protein stabilization;GO:0051090|regulation of DNA-binding transcription factor activity;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051444|negative regulation of ubiquitin-protein transferase activity;GO:0051726|regulation of cell cycle;GO:0051882|mitochondrial depolarization;GO:0060058|positive regulation of apoptotic process involved in mammary gland involution;GO:0061771|response to caloric restriction;GO:0070301|cellular response to hydrogen peroxide;GO:0070534|protein K63-linked ubiquitination;GO:0070542|response to fatty acid;GO:0071333|cellular response to glucose stimulus;GO:0090398|cellular senescence;GO:0090399|replicative senescence;GO:1900182|positive regulation of protein localization to nucleus;GO:1901798|positive regulation of signal transduction by p53 class mediator;GO:1902510|regulation of apoptotic DNA fragmentation;GO:1903051|negative regulation of proteolysis involved in cellular protein catabolic process;GO:1903214|regulation of protein targeting to mitochondrion;GO:1904667|negative regulation of ubiquitin protein ligase activity;GO:1990000|amyloid fibril formation;GO:2000059|negative regulation of ubiquitin-dependent protein catabolic process;GO:2000111|positive regulation of macrophage apoptotic process;GO:2000346|negative regulation of hepatocyte proliferation;GO:2000435|negative regulation of protein neddylation;GO:2000774|positive regulation of cellular senescence;","GO:0001652|granular component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0016604|nuclear body;GO:0032991|protein-containing complex;GO:0035985|senescence-associated heterochromatin focus;","GO:0002039|p53 binding;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0004861|cyclin-dependent protein serine/threonine kinase inhibitor activity;GO:0019789|SUMO transferase activity;GO:0019901|protein kinase binding;GO:0047485|protein N-terminus binding;GO:0051059|NF-kappaB binding;GO:0055105|ubiquitin-protein transferase inhibitor activity;GO:0097371|MDM2/MDM4 family protein binding;GO:0097718|disordered domain specific binding;GO:1990948|ubiquitin ligase inhibitor activity;","K06621","CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A"]
["ENSRNOG00000008683",119,7.655322144,56,3.615464141,2.117382954,1.082282222,{"v":1.64497e-06,"d":"1.64E-06"},{"v":1.34444E-6,"d":"1.34E-06"},"up","yes","Alk","protein_coding","chr6:22880625-23598034:+","gi|281182643|ref|NP_001162572.1|",7302,0,"ALK tyrosine kinase receptor precursor [Rattus norvegicus]","gi|408772020|ref|NM_001169101.2|",5440,0,"Rattus norvegicus anaplastic lymphoma receptor tyrosine kinase (Alk), mRNA","P97793",2718,0,"ALK tyrosine kinase receptor",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007275|multicellular organism development;GO:0007399|nervous system development;GO:0007420|brain development;GO:0016310|phosphorylation;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0021766|hippocampus development;GO:0030534|adult behavior;GO:0033674|positive regulation of kinase activity;GO:0036269|swimming behavior;GO:0042127|regulation of cell proliferation;GO:0043410|positive regulation of MAPK cascade;GO:0045664|regulation of neuron differentiation;GO:0046777|protein autophosphorylation;GO:0048666|neuron development;GO:0050995|negative regulation of lipid catabolic process;GO:0060159|regulation of dopamine receptor signaling pathway;GO:0090648|response to environmental enrichment;GO:0097009|energy homeostasis;GO:1900006|positive regulation of dendrite development;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0032991|protein-containing complex;GO:0043235|receptor complex;","GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0005524|ATP binding;GO:0042802|identical protein binding;","K05119","ALK, CD246; anaplastic lymphoma kinase [EC:2.7.10.1]"]
["ENSRNOG00000039191",42,2.701878404,9,0.581056737,4.649939037,2.217211802,{"v":1.6536e-06,"d":"1.65E-06"},{"v":1.3511e-06,"d":"1.35E-06"},"up","yes","Yjefn3","protein_coding","chr16:19533788-19539728:+","gi|392333569|ref|XP_001071564.3|",1254,{"v":8e-173,"d":"8.00E-173"},"PREDICTED: yjeF N-terminal domain-containing protein 3 isoform X1 [Rattus norvegicus]","gi|672029267|ref|XM_001071564.5|",756,0,"PREDICTED: Rattus norvegicus YjeF N-terminal domain containing 3 (Yjefn3), transcript variant X1, mRNA",".",".",".",".","YNL200c",134,{"v":2e-36,"d":"2.00E-36"},"COG0062","pfam03853","YjeF_N","YjeF-related protein N-terminus. YjeF-N domain is a novel version of the Rossmann fold with a set of catalytic residues and structural features that are different from the conventional dehydrogenases. YjeF-N domain is fused to Ribokinases in bacteria (YjeF), where they may be phosphatases, and to divergent Sm and the FDF domain in eukaryotes (Dcp3p and FLJ21128), where they may be involved in decapping and catalyze hydrolytic RNA-processing reactions.",".","GO:0005739|mitochondrion;","GO:0052856|NADHX epimerase activity;",".","."]
["ENSRNOG00000037798",44,2.83053928,10,0.645618597,4.384228235,2.132322904,{"v":1.69629e-06,"d":"1.70E-06"},{"v":1.3852e-06,"d":"1.39E-06"},"up","yes","Erich4","protein_coding","chr1:81123556-81125296:-","gi|157822377|ref|NP_001102923.1|",633,{"v":3E-79,"d":"3.00E-79"},"glutamate-rich protein 4 [Rattus norvegicus]","gi|157822376|ref|NM_001109453.1|",937,0,"Rattus norvegicus glutamate-rich 4 (Erich4), mRNA",".",".",".",".",".",".",".",".","pfam15039","DUF4530","Domain of unknown function (DUF4530). This family of proteins is found in eukaryotes. Proteins in this family are typically around 140 amino acids in length. The human member of this family is C19orf69.",".",".",".",".","."]
["ENSRNOG00000042224",87,5.596748122,35,2.259665088,2.476804263,1.30847986,{"v":1.89754e-06,"d":"1.90E-06"},{"v":1.54556E-6,"d":"1.55E-06"},"up","yes","Cyp2j10","protein_coding","chr5:110960317-110995115:-","gi|201066389|ref|NP_001128452.1|",2617,0,"cytochrome P450, family 2, subfamily j, polypeptide 10 [Rattus norvegicus]","gi|201066388|ref|NM_001134980.1|",1903,0,"Rattus norvegicus cytochrome P450, family 2, subfamily j, polypeptide 10 (Cyp2j10), mRNA","P51590",777,0,"Cytochrome P450 2J3","alr1450",135,{"v":3e-33,"d":"3.00E-33"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0006082|organic acid metabolic process;GO:0006805|xenobiotic metabolic process;GO:0019373|epoxygenase P450 pathway;GO:0042178|xenobiotic catabolic process;GO:0043651|linoleic acid metabolic process;","GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0005506|iron ion binding;GO:0008395|steroid hydroxylase activity;GO:0008404|arachidonic acid 14,15-epoxygenase activity;GO:0008405|arachidonic acid 11,12-epoxygenase activity;GO:0016712|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0016853|isomerase activity;GO:0020037|heme binding;GO:0071614|linoleic acid epoxygenase activity;","K07418","CYP2J; cytochrome P450 family 2 subfamily J [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]"]
["ENSRNOG00000069455",111,7.140678639,51,3.292654842,2.168669047,1.116809905,{"v":2.05397e-06,"d":"2.05E-06"},{"v":1.66513e-06,"d":"1.67E-06"},"up","yes","ENSRNOG00000069455","lncRNA","chr13:55352567-55355339:-",".",".",".",".","gi|924182123|ref|NM_145991.2|",1215,0,"Mus musculus cell division cycle 73, Paf1/RNA polymerase II complex component (Cdc73), mRNA",".",".",".",".",".",".",".",".","pfam14897","EpsG","EpsG family. This family of proteins are related to the EpsG protein from B. subtilis. These proteins are likely glycosyl transferases belonging to the membrane protein GT-C clan.",".",".",".",".","."]
["ENSRNOG00000019472",105,6.754696009,47,3.034407404,2.226034645,1.154476047,{"v":2.1097e-06,"d":"2.11E-06"},{"v":1.70837E-6,"d":"1.71E-06"},"up","yes","Ackr2","protein_coding","chr8:121561211-121573582:+","gi|55926223|ref|NP_511176.2|",1634,0,"atypical chemokine receptor 2 [Rattus norvegicus]","gi|672063550|ref|XM_008766664.1|",2729,0,"PREDICTED: Rattus norvegicus atypical chemokine receptor 2 (Ackr2), transcript variant X1, mRNA","O09027",630,0,"Atypical chemokine receptor 2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0006897|endocytosis;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007165|signal transduction;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0019722|calcium-mediated signaling;GO:0060326|cell chemotaxis;GO:0070098|chemokine-mediated signaling pathway;","GO:0005654|nucleoplasm;GO:0005769|early endosome;GO:0005829|cytosol;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0031965|nuclear membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0055037|recycling endosome;","GO:0005044|scavenger receptor activity;GO:0016493|C-C chemokine receptor activity;GO:0019957|C-C chemokine binding;","K04187","ACKR2, CCBP2; atypical chemokine receptor 2"]
["ENSRNOG00000069679",25,1.608260955,2,0.129123719,12.45519385,3.63867557,{"v":2.11217e-06,"d":"2.11E-06"},{"v":1.71013e-06,"d":"1.71E-06"},"up","yes","ENSRNOG00000069679","lncRNA","chr7:127402737-127422676:-",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","pfam03568","Peptidase_C50","Peptidase family C50.",".",".",".",".","."]
["ENSRNOG00000007049",121,7.78398302,58,3.74458786,2.078728905,1.055701623,{"v":2.18038e-06,"d":"2.18E-06"},{"v":1.76286e-06,"d":"1.76E-06"},"up","yes","Bcl11a","protein_coding","chr14:98030461-98124180:+","gi|300794336|ref|NP_001178612.1|",3539,0,"B-cell lymphoma/leukemia 11A [Rattus norvegicus]","gi|672077186|ref|XM_006251587.2|",3347,0,"PREDICTED: Rattus norvegicus B-cell CLL/lymphoma 11A (zinc finger protein) (Bcl11a), transcript variant X5, mRNA","Q9H165",1355,0,"B-cell lymphoma/leukemia 11A",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010976|positive regulation of neuron projection development;GO:0010977|negative regulation of neuron projection development;GO:0016925|protein sumoylation;GO:0030183|B cell differentiation;GO:0030217|T cell differentiation;GO:0048671|negative regulation of collateral sprouting;GO:0048672|positive regulation of collateral sprouting;GO:0050773|regulation of dendrite development;GO:1903860|negative regulation of dendrite extension;GO:1904800|negative regulation of neuron remodeling;GO:1905232|cellular response to L-glutamate;GO:2000171|negative regulation of dendrite development;GO:2000173|negative regulation of branching morphogenesis of a nerve;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0014069|postsynaptic density;GO:0016604|nuclear body;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001067|regulatory region nucleic acid binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0003712|transcription coregulator activity;GO:0003714|transcription corepressor activity;GO:0019901|protein kinase binding;GO:0046982|protein heterodimerization activity;","K22045","BCL11A; B-cell lymphoma/leukemia 11A"]
["ENSRNOG00000019942",62,3.988487167,20,1.291237193,3.088888075,1.627087596,{"v":2.21926e-06,"d":"2.22E-06"},{"v":1.79277E-6,"d":"1.79E-06"},"up","yes","Fbxo17","protein_coding","chr1:84002267-84024453:+","gi|149056450|gb|EDM07881.1|",665,{"v":3e-78,"d":"3.00E-78"},"rCG53655 [Rattus norvegicus]","gi|171543847|ref|NM_001013064.2|",836,0,"Rattus norvegicus F-box protein 17 (Fbxo17), mRNA","Q9QZM8",244,{"v":5e-72,"d":"5.00E-72"},"F-box only protein 17",".",".",".",".","pfam04300","FBA","F-box associated region. Members of this family are associated with F-box domains, hence the name FBA. This domain is probably involved in binding other proteins that will be targeted for ubiquitination. Human FBXO2 is involved in binding to N-glycosylated proteins.","GO:0006516|glycoprotein catabolic process;GO:0016567|protein ubiquitination;GO:0030433|ubiquitin-dependent ERAD pathway;GO:0031146|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;","GO:0005737|cytoplasm;GO:0019005|SCF ubiquitin ligase complex;","GO:0061630|ubiquitin protein ligase activity;","K10101","FBXO17, FBXO26; F-box protein 17"]
["ENSRNOG00000015903",22,1.41526964,1,0.06456186,21.92114118,4.454250999,{"v":2.26575e-06,"d":"2.27E-06"},{"v":1.82903E-6,"d":"1.83E-06"},"up","yes","Add2","protein_coding","chr4:118497416-118538505:+","gi|6978449|ref|NP_036623.1|",3051,0,"beta-adducin isoform b [Rattus norvegicus]","gi|158081760|ref|NM_012491.2|",3251,0,"Rattus norvegicus adducin 2 (Add2), transcript variant 2, mRNA","Q9QYB8",1123,0,"Beta-adducin","CC1201",144,{"v":1e-36,"d":"1.00E-36"},"COG0235","pfam00596","Aldolase_II","Class II Aldolase and Adducin N-terminal domain. This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.","GO:0006811|ion transport;GO:0007416|synapse assembly;GO:0030097|hemopoiesis;GO:0032092|positive regulation of protein binding;GO:0050900|leukocyte migration;GO:0050901|leukocyte tethering or rolling;GO:0051016|barbed-end actin filament capping;GO:0051017|actin filament bundle assembly;GO:0065003|protein-containing complex assembly;","GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0008290|F-actin capping protein complex;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0031410|cytoplasmic vesicle;GO:0044853|plasma membrane raft;GO:0098794|postsynapse;GO:0098978|glutamatergic synapse;","GO:0003779|actin binding;GO:0005200|structural constituent of cytoskeleton;GO:0005516|calmodulin binding;GO:0019901|protein kinase binding;GO:0030507|spectrin binding;GO:0042803|protein homodimerization activity;GO:0046982|protein heterodimerization activity;GO:0051015|actin filament binding;","K18622","ADD; adducin"]
["ENSRNOG00000062794",22,1.41526964,1,0.06456186,21.92114118,4.454250999,{"v":2.26575e-06,"d":"2.27E-06"},{"v":1.82903E-6,"d":"1.83E-06"},"up","yes","Gypa","protein_coding","chr19:27450308-27465822:-","gi|149037943|gb|EDL92303.1|",499,{"v":9e-58,"d":"9.00E-58"},"rCG51636 [Rattus norvegicus]","gi|298904585|emb|FQ225003.1|",1211,0,"Rattus norvegicus TL0AEA55YH08 mRNA sequence","P14220",76.3,{"v":9e-15,"d":"9.00E-15"},"Glycophorin-A",".",".",".",".","pfam01102","Glycophorin_A","Glycophorin A.",".",".",".",".","."]
["ENSRNOG00000010158",37,2.380226213,7,0.451933018,5.266767685,2.396917824,{"v":2.44204e-06,"d":"2.44E-06"},{"v":1.9644e-06,"d":"1.96E-06"},"up","yes","Magel2","protein_coding","chr1:115880474-115884250:+","gi|392344312|ref|XP_001054803.2|",4326,0,"PREDICTED: MAGE-like protein 2 [Rattus norvegicus]","gi|672013777|ref|XM_002725637.4|",3777,0,"PREDICTED: Rattus norvegicus MAGE-like 2 (Magel2), mRNA","Q9QZ04",1477,0,"MAGE-like protein 2",".",".",".",".","pfam01454","MAGE","MAGE family. The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumors but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0034314|Arp2/3 complex-mediated actin nucleation;GO:0042147|retrograde transport, endosome to Golgi;GO:0042752|regulation of circadian rhythm;GO:0045892|negative regulation of transcription, DNA-templated;GO:0051127|positive regulation of actin nucleation;GO:0070534|protein K63-linked ubiquitination;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005829|cytosol;GO:0030904|retromer complex;","GO:0004842|ubiquitin-protein transferase activity;","K23950","MAGEL2; MAGE-like protein 2"]
["ENSRNOG00000020165",37,2.380226213,7,0.451933018,5.266767685,2.396917824,{"v":2.44204e-06,"d":"2.44E-06"},{"v":1.9644e-06,"d":"1.96E-06"},"up","yes","Ahsp","protein_coding","chr1:182880076-182885506:+","gi|157820931|ref|NP_001099769.1|",469,{"v":9e-56,"d":"9.00E-56"},"alpha-hemoglobin-stabilizing protein [Rattus norvegicus]","gi|157820930|ref|NM_001106299.1|",499,0,"Rattus norvegicus alpha hemoglobin stabilizing protein (Ahsp), mRNA","Q9CY02",153,{"v":7E-45,"d":"7.00E-45"},"Alpha-hemoglobin-stabilizing protein",".",".",".",".","pfam09236","AHSP","Alpha-haemoglobin stabilizing protein. Alpha-haemoglobin stabilizing protein (AHSP) acts a molecular chaperone for free alpha-haemoglobin, preventing the harmful aggregation of alpha-haemoglobin during normal erythroid cell development: it specifically protects free alpha-haemoglobin from precipitation. AHSP adopts a helical secondary structure consisting of an elongated antiparallel three alpha-helix bundle.","GO:0006457|protein folding;GO:0008150|biological_process;GO:0030218|erythrocyte differentiation;GO:0050821|protein stabilization;","GO:0005575|cellular_component;GO:0005737|cytoplasm;","GO:0003674|molecular_function;GO:0030492|hemoglobin binding;",".","."]
["ENSRNOG00000001005",51,3.280852347,14,0.903866035,3.629799351,1.859889801,{"v":2.45067e-06,"d":"2.45E-06"},{"v":1.97106e-06,"d":"1.97E-06"},"up","yes","Fcer2","protein_coding","chr12:1742815-1754476:-","gi|76781460|ref|NP_001029096.1|",1572,0,"low affinity immunoglobulin epsilon Fc receptor isoform a [Rattus norvegicus]","gi|76781459|ref|NM_001033924.1|",1995,0,"Rattus norvegicus Fc fragment of IgE receptor II (Fcer2), transcript variant 1, mRNA","P20693",555,0,"Low affinity immunoglobulin epsilon Fc receptor",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0002925|positive regulation of humoral immune response mediated by circulating immunoglobulin;GO:0051000|positive regulation of nitric-oxide synthase activity;GO:0051712|positive regulation of killing of cells of other organism;GO:0051770|positive regulation of nitric-oxide synthase biosynthetic process;","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0030246|carbohydrate binding;","K06468","FCER2, CD23; low affinity immunoglobulin epsilon Fc receptor"]
["ENSRNOG00000026112",103,6.626035133,46,2.969845544,2.23110429,1.157757952,{"v":2.50267e-06,"d":"2.50E-06"},{"v":2.01119e-06,"d":"2.01E-06"},"up","yes","Tmem202","protein_coding","chr8:59910824-59916609:-","gi|157820301|ref|NP_001103106.1|",1415,0,"transmembrane protein 202 [Rattus norvegicus]","gi|157820300|ref|NM_001109636.1|",1282,0,"Rattus norvegicus transmembrane protein 202 (Tmem202), mRNA","Q80W35",391,{"v":2e-133,"d":"2.00E-133"},"Transmembrane protein 202",".",".",".",".","pfam00822","PMP22_Claudin","PMP-22/EMP/MP20/Claudin family.",".","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000013840",30,1.929913146,4,0.258247439,7.47311631,2.901709976,{"v":2.51174e-06,"d":"2.51E-06"},{"v":2.01763e-06,"d":"2.02E-06"},"up","yes","Ankrd2","protein_coding","chr1:240847072-240856566:+","gi|157820209|ref|NP_001101059.1|",1542,0,"ankyrin repeat domain-containing protein 2 [Rattus norvegicus]","gi|157820208|ref|NM_001107589.1|",1032,0,"Rattus norvegicus ankyrin repeat domain 2 (Ankrd2), mRNA","Q9WV06",563,0,"Ankyrin repeat domain-containing protein 2","all2748",92.8,{"v":1e-19,"d":"1.00E-19"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001817|regulation of cytokine production;GO:0006357|regulation of transcription by RNA polymerase II;GO:0010832|negative regulation of myotube differentiation;GO:0035914|skeletal muscle cell differentiation;GO:0043619|regulation of transcription from RNA polymerase II promoter in response to oxidative stress;GO:0045662|negative regulation of myoblast differentiation;GO:1902253|regulation of intrinsic apoptotic signaling pathway by p53 class mediator;GO:2000291|regulation of myoblast proliferation;","GO:0000791|euchromatin;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016605|PML body;GO:0030016|myofibril;GO:0030017|sarcomere;GO:0031674|I band;GO:0043231|intracellular membrane-bounded organelle;","GO:0003682|chromatin binding;GO:0031432|titin binding;GO:0043422|protein kinase B binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;","K21434","ANKRD2; ankyrin repeat domain-containing protein 2"]
["ENSRNOG00000062835",30,1.929913146,4,0.258247439,7.47311631,2.901709976,{"v":2.51174e-06,"d":"2.51E-06"},{"v":2.01763e-06,"d":"2.02E-06"},"up","yes","ENSRNOG00000062835","protein_coding","chr5:60256314-60276810:-","gi|37361874|gb|AAQ91050.1|",282,{"v":1e-24,"d":"1.00E-24"},"LRRGT00094 [Rattus norvegicus]","gi|401461827|gb|AC246663.5|",855,0,"Rattus norvegicus Y Chr BAC RNECO-121H12 (Amplicon Express Rat SHR-Akr (EcoR1 Digest) BAC library) complete sequence","P31789",91.3,{"v":6e-18,"d":"6.00E-18"},"Envelope glycoprotein",".",".",".",".","pfam01500","Keratin_B2","Keratin, high sulfur B2 protein. High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.",".",".",".",".","."]
["ENSRNOG00000013586",49,3.152191471,13,0.839304176,3.755719992,1.909089507,{"v":2.59137e-06,"d":"2.59E-06"},{"v":2.07779E-6,"d":"2.08E-06"},"up","yes","Snai3","protein_coding","chr19:50516771-50523486:-","gi|157823589|ref|NP_001100909.1|",1511,0,"zinc finger protein SNAI3 [Rattus norvegicus]","gi|672085234|ref|XM_008772612.1|",1594,0,"PREDICTED: Rattus norvegicus snail family zinc finger 3 (Snai3), transcript variant X2, mRNA","Q9QY31",541,0,"Zinc finger protein SNAI3",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:1990837|sequence-specific double-stranded DNA binding;","K09217","SNAI3; snail 3"]
["ENSRNOG00000065187",39,2.508887089,8,0.516494877,4.857525601,2.2802216,{"v":2.63924e-06,"d":"2.64E-06"},{"v":2.11558E-6,"d":"2.12E-06"},"up","yes","ENSRNOG00000065187","protein_coding","chr8:57909697-57913141:+","gi|690448686|ref|XP_009324661.1|",177,{"v":8E-14,"d":"8.00E-14"},"PREDICTED: 60S ribosomal protein L12 [Pygoscelis adeliae]","gi|751662876|ref|NG_041833.1|",111,{"v":2e-49,"d":"2.00E-49"},"Rattus norvegicus ribosomal protein L12, pseudogene 1 (Rpl12-ps1) on chromosome 8","P30050",69.3,{"v":4E-14,"d":"4.00E-14"},"60S ribosomal protein L12","SPCC31H12.04c",58.2,{"v":9e-11,"d":"9.00E-11"},"COG0080","pfam03946","Ribosomal_L11_N","Ribosomal protein L11, N-terminal domain. The N-terminal domain of Ribosomal protein L11 adopts an alpha/beta fold and is followed by the RNA binding C-terminal domain.",".",".",".",".","."]
["ENSRNOG00000008693",47,3.023530595,12,0.774742316,3.902627406,1.964445732,{"v":2.70362E-6,"d":"2.70E-06"},{"v":2.16476e-06,"d":"2.16E-06"},"up","yes","Tssk3","protein_coding","chr5:141827606-141829255:-","gi|504161247|ref|XP_004591677.1|",1436,0,"PREDICTED: testis-specific serine/threonine-protein kinase 3 [Ochotona princeps]","gi|56090248|ref|NM_001007650.1|",1003,0,"Rattus norvegicus testis-specific serine kinase 3 (Tssk3), mRNA","Q9D2E1",555,0,"Testis-specific serine/threonine-protein kinase 3",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006468|protein phosphorylation;GO:0007283|spermatogenesis;GO:0035556|intracellular signal transduction;",".","GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;","K08811","TSSK, STK22; testis-specific serine kinase [EC:2.7.11.1]"]
["ENSRNOG00000024420",78,5.017774178,30,1.93685579,2.590680321,1.373331004,{"v":2.84699e-06,"d":"2.85E-06"},{"v":2.27477e-06,"d":"2.27E-06"},"up","yes","Eme1","protein_coding","chr10:79586729-79595435:-","gi|164663911|ref|NP_001099300.2|",2516,0,"crossover junction endonuclease EME1 [Rattus norvegicus]","gi|672068455|ref|XM_006247179.2|",1603,0,"PREDICTED: Rattus norvegicus essential meiotic structure-specific endonuclease 1 (Eme1), transcript variant X1, mRNA","Q8BJW7",793,0,"Crossover junction endonuclease EME1",".",".",".",".","pfam15265","FAM196","FAM196 family. This protein family is a domain of unknown function. This family of proteins is found in eukaryotes and are typically between 441 and 534 amino acids in length.","GO:0000712|resolution of meiotic recombination intermediates;GO:0006302|double-strand break repair;GO:0031297|replication fork processing;GO:0031573|intra-S DNA damage checkpoint;GO:0072429|response to intra-S DNA damage checkpoint signaling;GO:0090305|nucleic acid phosphodiester bond hydrolysis;","GO:0000785|chromatin;GO:0000792|heterochromatin;GO:0005634|nucleus;GO:0048476|Holliday junction resolvase complex;","GO:0003677|DNA binding;GO:0004519|endonuclease activity;","K10882","EME1, MMS4; crossover junction endonuclease EME1 [EC:3.1.22.-]"]
["ENSRNOG00000017130",32,2.058574022,5,0.322809298,6.377059251,2.672891286,{"v":3.1726e-06,"d":"3.17E-06"},{"v":2.52715E-6,"d":"2.53E-06"},"up","yes","Rhd","protein_coding","chr5:147087518-147121715:+","gi|11968076|ref|NP_071950.1|",2164,0,"blood group Rh(D) polypeptide [Rattus norvegicus]","gi|40254767|ref|NM_022505.2|",1482,0,"Rattus norvegicus Rh blood group, D antigen (Rhd), mRNA","O88298",838,0,"Blood group Rh(D) polypeptide",".",".",".",".","pfam00909","Ammonium_transp","Ammonium Transporter Family.","GO:0015696|ammonium transport;GO:0048821|erythrocyte development;GO:0060586|multicellular organismal iron ion homeostasis;GO:0072488|ammonium transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0016020|membrane;","GO:0008519|ammonium transmembrane transporter activity;","K06579","RH, CD240; Rhesus blood group glycoprotein"]
["ENSRNOG00000029339",111,7.140678639,52,3.357216702,2.126963873,1.088795529,{"v":3.29585E-6,"d":"3.30E-06"},{"v":2.62204e-06,"d":"2.62E-06"},"up","yes","Ndufs5","protein_coding","chr2:182339360-182339853:+","gi|149023886|gb|EDL80383.1|",564,{"v":4e-71,"d":"4.00E-71"},"rCG31129, isoform CRA_a [Rattus norvegicus]","gi|298897114|emb|FQ224355.1|",487,0,"Rattus norvegicus TL0ACA69YI02 mRNA sequence","Q99LY9",203,{"v":4e-66,"d":"4.00E-66"},"NADH dehydrogenase [ubiquinone] iron-sulfur protein 5",".",".",".",".","pfam10200","Ndufs5","NADH:ubiquinone oxidoreductase, NDUFS5-15kDa. This is a family of short, approximately 105 amino acid residue, proteins which form part of NADH:ubiquinone oxidoreductase complex I. Complex I is the first multisubunit inner membrane protein complex of the mitochondrial electron transport chain and it transfers two electrons from NADH to ubiquinone. The protein carries four highly conserved cysteine residues but these do not appear to be in a configuration which would favour metal binding so the exact function of the protein is uncertain.",".",".",".","K03938","NDUFS5; NADH dehydrogenase (ubiquinone) Fe-S protein 5"]
["ENSRNOG00000038228",90,5.789739437,38,2.453350667,2.359931466,1.238744964,{"v":3.43362e-06,"d":"3.43E-06"},{"v":2.72519e-06,"d":"2.73E-06"},"up","yes","Serp2","protein_coding","chr15:51879877-51904785:-","gi|568988885|ref|XP_006519662.1|",517,{"v":2e-59,"d":"2.00E-59"},"PREDICTED: stress-associated endoplasmic reticulum protein 2 isoform X1 [Mus musculus]","gi|157819352|ref|NM_001109104.1|",739,0,"Rattus norvegicus stress-associated endoplasmic reticulum protein family member 2 (Serp2), mRNA","Q6TAW2",111,{"v":4e-28,"d":"4.00E-28"},"Stress-associated endoplasmic reticulum protein 2",".",".",".",".","pfam06624","RAMP4","Ribosome associated membrane protein RAMP4. This family consists of several ribosome associated membrane protein RAMP4 (or SERP1) sequences. Stabilisation of membrane proteins in response to stress involves the concerted action of a rescue unit in the ER membrane comprised of SERP1/RAMP4, other components of the translocon, and molecular chaperones in the ER.","GO:0006486|protein glycosylation;GO:0015031|protein transport;GO:0030968|endoplasmic reticulum unfolded protein response;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000065586",20,1.286608764,0,0.03228093,39.85662032,5.316747476,{"v":3.58651e-06,"d":"3.59E-06"},{"v":2.84337e-06,"d":"2.84E-06"},"up","yes","ENSRNOG00000065586","lncRNA","chr8:49847620-49849412:+","gi|149065155|gb|EDM15231.1|",183,{"v":1E-13,"d":"1.00E-13"},"rCG28366 [Rattus norvegicus]","gi|49615128|gb|AC106169.5|",246,{"v":6E-124,"d":"6.00E-124"},"Rattus norvegicus x BAC CH230-105D14 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam01757","Acyl_transf_3","Acyltransferase family. This family includes a range of acyltransferase enzymes. This domain is found in many as yet uncharacterized C. elegans proteins and it is approximately 300 amino acids long.",".",".",".",".","."]
["ENSRNOG00000069960",20,1.286608764,0,0.03228093,39.85662032,5.316747476,{"v":3.58651e-06,"d":"3.59E-06"},{"v":2.84337e-06,"d":"2.84E-06"},"up","yes","5_8S_rRNA","rRNA","chr3:2234750-2234902:+","gi|954258002|gb|KRX51787.1|",138,1E-8,"hypothetical protein T09_8305 [Trichinella sp. T9]","gi|958786664|ref|XM_014867045.1|",153,{"v":3e-73,"d":"3.00E-73"},"PREDICTED: Equus asinus translation initiation factor IF-2-like (LOC106847650), mRNA",".",".",".",".",".",".",".",".","pfam05346","DUF747","Eukaryotic membrane protein family. This family is a family of eukaryotic membrane proteins. It was previously annotated as including a putative receptor for human cytomegalovirus gH but this has has since been disputed. Analysis of the mouse Tapt1 protein (transmembrane anterior posterior transformation 1) has shown it to be involved in patterning of the vertebrate axial skeleton.",".",".",".",".","."]
["ENSRNOG00000015061",24,1.543930516,2,0.129123719,11.9569861,3.579781881,{"v":3.86983e-06,"d":"3.87E-06"},{"v":3.06034E-6,"d":"3.06E-06"},"up","yes","Igfals","protein_coding","chr10:13898395-13902677:+","gi|149052066|gb|EDM03883.1|",2667,0,"insulin-like growth factor binding protein, acid labile subunit, isoform CRA_a [Rattus norvegicus]","gi|3093473|gb|AF006203.1|AF006203",2070,0,"Rattus norvegicus insulin-like growth factor binding protein complex acid-labile subunit gene, complete cds","P35859",1024,0,"Insulin-like growth factor-binding protein complex acid labile subunit","SPy1798",88.6,{"v":4e-17,"d":"4.00E-17"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0007155|cell adhesion;GO:0007568|aging;GO:0031667|response to nutrient levels;GO:0071347|cellular response to interleukin-1;GO:0071364|cellular response to epidermal growth factor stimulus;GO:0071378|cellular response to growth hormone stimulus;GO:0071549|cellular response to dexamethasone stimulus;","GO:0005615|extracellular space;GO:0031012|extracellular matrix;GO:0042567|insulin-like growth factor ternary complex;","GO:0005520|insulin-like growth factor binding;","K17256","IGFALS, ALS; insulin-like growth factor-binding protein complex acid labile subunit"]
["ENSRNOG00000007980",50,3.216521909,14,0.903866035,3.558626814,1.831320648,{"v":3.89522e-06,"d":"3.90E-06"},{"v":3.07872E-6,"d":"3.08E-06"},"up","yes","Anxa13","protein_coding","chr7:89884356-89936907:-","gi|201027432|ref|NP_001128382.1|",1634,0,"annexin A13 [Rattus norvegicus]","gi|201027431|ref|NM_001134910.1|",1571,0,"Rattus norvegicus annexin A13 (Anxa13), mRNA","Q99JG3",603,0,"Annexin A13",".",".",".",".","pfam00191","Annexin","Annexin. This family of annexins also includes giardin that has been shown to function as an annexin.","GO:0042997|negative regulation of Golgi to plasma membrane protein transport;GO:0042998|positive regulation of Golgi to plasma membrane protein transport;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0019898|extrinsic component of membrane;GO:0045121|membrane raft;GO:0070382|exocytic vesicle;","GO:0001786|phosphatidylserine binding;GO:0005509|calcium ion binding;GO:0005544|calcium-dependent phospholipid binding;GO:1901611|phosphatidylglycerol binding;","K17099","ANXA13; annexin A13"]
["ENSRNOG00000062997",88,5.66107856,37,2.388788807,2.3698531,1.244797634,{"v":4.05132e-06,"d":"4.05E-06"},{"v":3.1937E-6,"d":"3.19E-06"},"up","yes","ENSRNOG00000062997","protein_coding","chr9:95976958-95981417:+","gi|37654232|gb|AAQ96221.1|",697,{"v":6e-172,"d":"6.00E-172"},"LRRGT00008 [Rattus norvegicus]","gi|46810386|gb|AC147047.2|",1090,0,"Mus musculus BAC clone RP23-97D19 from chromosome 6, complete sequence","P11260",305,{"v":8e-93,"d":"8.00E-93"},"LINE-1 retrotransposable element ORF1 protein",".",".",".",".","pfam02994","Transposase_22","L1 transposable element.",".",".",".",".","."]
["ENSRNOG00000066763",97,6.240052504,43,2.776159965,2.247728006,1.168467468,{"v":4.17564e-06,"d":"4.18E-06"},{"v":3.28717e-06,"d":"3.29E-06"},"up","yes","ENSRNOG00000066763","protein_coding","chr1:7270339-7270828:+","gi|291230978|ref|XP_002735441.1|",215,{"v":2e-20,"d":"2.00E-20"},"PREDICTED: U6 snRNA-associated Sm-like protein LSm2-like [Saccoglossus kowalevskii]",".",".",".",".","O35900",80.9,{"v":3e-19,"d":"3.00E-19"},"U6 snRNA-associated Sm-like protein LSm2",".",".",".",".","pfam15625","CC2D2AN-C2","CC2D2A N-terminal C2 domain. Many ciliary proteins are involved in ciliogenesis and implicated for ciliophathies. A recent study has shown that many of them contain various new versions of C2 domains which are predicted to mediate membrane localizations for Y-shaped linkers of transition zone of cilia. This is the first C2 domain of ciliary CC2D2A proteins which also have another C2 domain (CC2D2AC-C2) and a new inactive transglutaminase-like peptidase domain (CC2D2A-TGL).",".",".",".",".","."]
["ENSRNOG00000006236",113,7.269339515,54,3.486340421,2.085091711,1.060110841,{"v":4.38366e-06,"d":"4.38E-06"},{"v":3.44617e-06,"d":"3.45E-06"},"up","yes","Dsn1","protein_coding","chr3:145652737-145665856:-","gi|564343903|ref|XP_006235437.1|",1670,0,"PREDICTED: kinetochore-associated protein DSN1 homolog isoform X2 [Rattus norvegicus]","gi|672047617|ref|XM_006235375.2|",2066,0,"PREDICTED: Rattus norvegicus DSN1, MIS12 kinetochore complex component (Dsn1), transcript variant X1, mRNA","Q9CYC5",584,0,"Kinetochore-associated protein DSN1 homolog","SPCC576.08c",141,{"v":8e-36,"d":"8.00E-36"},"COG0098","pfam08202","MIS13","Mis12-Mtw1 protein family. Mis12-Mtw1 is a eukaryotic conserved kinetochore protein that is involved in chromosome segregation.","GO:0000070|mitotic sister chromatid segregation;GO:0051301|cell division;","GO:0000444|MIS12/MIND type complex;GO:0000776|kinetochore;GO:0000818|nuclear MIS12/MIND complex;GO:0001650|fibrillar center;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005829|cytosol;GO:0016604|nuclear body;",".","K11544","DSN1; kinetochore-associated protein DSN1"]
["ENSRNOG00000015259",29,1.865582707,4,0.258247439,7.224012433,2.852800376,{"v":4.45853e-06,"d":"4.46E-06"},{"v":3.50166E-6,"d":"3.50E-06"},"up","yes","Pth2r","protein_coding","chr9:66706050-66810036:+","gi|149045964|gb|EDL98857.1|",2790,0,"parathyroid hormone receptor 2, isoform CRA_a [Rattus norvegicus]","gi|451958082|ref|NM_031089.2|",1960,0,"Rattus norvegicus parathyroid hormone 2 receptor (Pth2r), mRNA","P70555",1069,0,"Parathyroid hormone 2 receptor",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0007166|cell surface receptor signaling pathway;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007188|adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0120162|positive regulation of cold-induced thermogenesis;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004991|parathyroid hormone receptor activity;GO:0008528|G protein-coupled peptide receptor activity;GO:0017046|peptide hormone binding;","K04586","PTHR2; parathyroid hormone receptor 2"]
["ENSRNOG00000060310",67,4.310139358,24,1.549484632,2.78165996,1.47594607,{"v":4.62919e-06,"d":"4.63E-06"},{"v":3.6317e-06,"d":"3.63E-06"},"up","yes","ENSRNOG00000060310","protein_coding","chr19:8695215-8696228:+","gi|6679299|ref|NP_032857.1|",1209,{"v":4e-164,"d":"4.00E-164"},"prohibitin [Mus musculus]","gi|672031037|ref|XR_342138.2|",1001,0,"PREDICTED: Rattus norvegicus similar to prohibitin (LOC688815), misc_RNA","P67779",470,{"v":1E-165,"d":"1.00E-165"},"Prohibitin","YGR132c",263,{"v":8e-85,"d":"8.00E-85"},"COG0330","pfam01145","Band_7","SPFH domain / Band 7 family. This family has been called SPFH, Band 7 or PHB domain. Recent phylogenetic analysis has shown this domain to be a slipin or Stomatin-like integral membrane domain conserved from protozoa to mammals.",".",".",".",".","."]
["ENSRNOG00000032639",101,6.497374257,46,2.969845544,2.187781876,1.129468907,{"v":4.86754e-06,"d":"4.87E-06"},{"v":3.81292e-06,"d":"3.81E-06"},"up","yes","Foxo6","protein_coding","chr5:133856072-133876573:-","gi|109475418|ref|XP_001057233.1|",1080,{"v":8e-131,"d":"8.00E-131"},"PREDICTED: forkhead box protein O6 [Rattus norvegicus]","gi|564352641|ref|XM_001057233.4|",2124,0,"PREDICTED: Rattus norvegicus forkhead box O6 (Foxo6), mRNA","Q70KY4",417,{"v":4e-131,"d":"4.00E-131"},"Forkhead box protein O6","ECU01g0470",60.8,2e-09,"COG5025","pfam00250","Fork_head","Fork head domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0007613|memory;GO:0060999|positive regulation of dendritic spine development;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;","K17847","FOXO6; forkhead box protein O6"]
["ENSRNOG00000066247",114,7.333669953,55,3.550902281,2.065297598,1.046349681,{"v":5.02887e-06,"d":"5.03E-06"},{"v":3.93552e-06,"d":"3.94E-06"},"up","yes","Sugct","protein_coding","chr17:47376521-48234376:+","gi|62079027|ref|NP_001014168.1|",2224,0,"succinate--hydroxymethylglutarate CoA-transferase [Rattus norvegicus]","gi|62079026|ref|NM_001014146.1|",1704,0,"Rattus norvegicus succinylCoA:glutarate-CoA transferase (Sugct), mRNA","Q68FU4",861,0,"Succinate--hydroxymethylglutarate CoA-transferase","RSc0796",363,{"v":1e-118,"d":"1.00E-118"},"COG1804","pfam02515","CoA_transf_3","CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.",".",".",".",".","."]
["ENSRNOG00000065802",65,4.181478482,23,1.484922772,2.81595687,1.493625238,{"v":5.31091e-06,"d":"5.31E-06"},{"v":4.14999e-06,"d":"4.15E-06"},"up","yes","ENSRNOG00000065802","lncRNA","chr8:70033349-70034736:-",".",".",".",".","gi|672062535|ref|XM_008766410.1|",1388,0,"PREDICTED: Rattus norvegicus RAR-related orphan receptor A (Rora), transcript variant X4, mRNA",".",".",".",".",".",".",".",".","pfam10959","DUF2761","Protein of unknown function (DUF2761). Members in this family of proteins are annotated as KleF however no function is known.",".",".",".",".","."]
["ENSRNOG00000062781",31,1.994243584,5,0.322809298,6.17777615,2.627087596,{"v":5.53885e-06,"d":"5.54E-06"},{"v":4.31746e-06,"d":"4.32E-06"},"up","yes","Ugt2b10","protein_coding","chr14:21108006-21127828:+","gi|300794198|ref|NP_001178605.1|",2688,0,"UDP-glucuronosyltransferase 2B10 precursor [Rattus norvegicus]","gi|300794197|ref|NM_001191676.1|",1599,0,"Rattus norvegicus UDP glucuronosyltransferase 2 family, polypeptide B10 (Ugt2b10), mRNA","Q6K1J1",766,0,"UDP-glucuronosyltransferase 2B31","slr1125",70.1,{"v":7e-12,"d":"7.00E-12"},"COG1819","pfam00201","UDPGT","UDP-glucoronosyl and UDP-glucosyl transferase.",".",".",".",".","."]
["ENSRNOG00000068643",76,4.889113302,30,1.93685579,2.52425262,1.335856298,{"v":6.05852e-06,"d":"6.06E-06"},{"v":4.70648E-6,"d":"4.71E-06"},"up","yes","ENSRNOG00000068643","lncRNA","chr2:147812346-147825166:+","gi|37654254|gb|AAQ96232.1|",224,{"v":2E-16,"d":"2.00E-16"},"LRRGT00019 [Rattus norvegicus]","gi|25711613|gb|AC121840.3|",363,0,"Mus musculus BAC clone RP24-79E2 from chromosome 3, complete sequence",".",".",".",".",".",".",".",".","pfam15350","ETAA1","Ewing's tumor-associated antigen 1 homologue. This family of proteins is found in eukaryotes, where members are expressed at high levels in the brain, liver kidney and Ewing tumor cell lines. Proteins in this family are typically between 648 and 898 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000050177",49,3.152191471,14,0.903866035,3.487454278,1.802174303,{"v":6.16861e-06,"d":"6.17E-06"},{"v":4.7868e-06,"d":"4.79E-06"},"up","yes","ENSRNOG00000050177","protein_coding","chrX:150990735-151003268:-","gi|392344403|ref|XP_003748951.1|",1247,{"v":1E-168,"d":"1.00E-168"},"PREDICTED: X-linked lymphocyte-regulated protein 3A-like isoform X4 [Rattus norvegicus]","gi|672037449|ref|XM_006229620.2|",1100,0,"PREDICTED: Rattus norvegicus synaptonemal complex protein 3-like (LOC100911002), transcript variant X7, mRNA","Q9JJR2",249,{"v":4E-79,"d":"4.00E-79"},"X-linked lymphocyte-regulated protein 5C",".",".",".",".","pfam04803","Cor1","Cor1/Xlr/Xmr conserved region. Cor1 is a component of the chromosome core in the meiotic prophase chromosomes. Xlr is a lymphoid cell specific protein. Xlm is abundantly transcribed in testis in a tissue-specific and developmentally regulated manner. The protein is located in the nuclei of spermatocytes, early in the prophase of the first meiotic division, and later becomes concentrated in the XY nuclear subregion where it is in particular associated with the axes of sex chromosomes.",".",".",".",".","."]
["ENSRNOG00000070692",49,3.152191471,14,0.903866035,3.487454278,1.802174303,{"v":6.16861e-06,"d":"6.17E-06"},{"v":4.7868e-06,"d":"4.79E-06"},"up","yes","ENSRNOG00000070692","protein_coding","chr15:4782866-4790453:+","gi|564385445|ref|XP_006251744.1|",666,{"v":1E-78,"d":"1.00E-78"},"PREDICTED: uncharacterized protein LOC102547093 isoform X2 [Rattus norvegicus]","gi|672077354|ref|XR_595997.1|",795,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103693798 (LOC103693798), ncRNA",".",".",".",".",".",".",".",".","pfam04822","Takusan","Takusan. This domain is named takusan, which is a Japanese word meaning 'many'. Members of this family regulate synaptic activity.",".",".",".",".","."]
["ENSRNOG00000008100",106,6.819026448,50,3.228092983,2.112400877,1.078883645,{"v":6.42622e-06,"d":"6.43E-06"},{"v":4.97589e-06,"d":"4.98E-06"},"up","yes","Rgs20","protein_coding","chr5:14534775-14614084:+","gi|149060975|gb|EDM11585.1|",1116,{"v":9e-147,"d":"9.00E-147"},"similar to Regulator of G-protein signaling 20 (RGS20) (Regulator of G-protein signaling Z1) [Rattus norvegicus]","gi|169642748|gb|BC160842.1|",1679,0,"Rattus norvegicus regulator of G-protein signaling 20, mRNA (cDNA clone MGC:187568 IMAGE:8361585), complete cds","Q9QZB1",404,{"v":2E-136,"d":"2.00E-136"},"Regulator of G-protein signaling 20",".",".",".",".","pfam00615","RGS","Regulator of G protein signaling domain. RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.","GO:0001975|response to amphetamine;","GO:0005737|cytoplasm;GO:0005802|trans-Golgi network;",".","K16449","RGS; regulator of G-protein signaling"]
["ENSRNOG00000018426",113,7.269339515,55,3.550902281,2.047180953,1.03363863,{"v":6.8524e-06,"d":"6.85E-06"},{"v":5.29654e-06,"d":"5.30E-06"},"up","yes","NEWGENE_2134","protein_coding","chr1:79346136-79350375:-","gi|564401235|ref|XP_003752293.2|",291,{"v":7e-27,"d":"7.00E-27"},"PREDICTED: apolipoprotein C-I-like [Rattus norvegicus]","gi|354798497|gb|JN962998.1|",317,{"v":7e-163,"d":"7.00E-163"},"Mus musculus targeted deletion, lacZ-tagged mutant allele Apoc4:tm1(KOMP)Ucd; transgenic","P19939",86.3,{"v":6e-18,"d":"6.00E-18"},"Apolipoprotein C-I",".",".",".",".","pfam04691","ApoC-I","Apolipoprotein C-I (ApoC-1). Apolipoprotein C-I (ApoC-1) is a water-soluble protein component of plasma lipoprotein. It solubalises lipids and regulates lipid metabolizm. ApoC-1 transfers among HDL (high density lipoprotein), VLDL (very low-density lipoprotein) and chylomicrons. ApoC-1 activates lecithin:choline acetyltransferase (LCAT), inhibits cholesteryl ester transfer protein, can inhibit hepatic lipase and phospholipase 2 and can stimulate cell growth. ApoC-1 delays the clearance of beta-VLDL by inhibiting its uptake via the LDL receptor-related pathway. ApoC-1 has been implicated in hypertriglyceridemia, and Alzheimer's disease.","GO:0006641|triglyceride metabolic process;GO:0006869|lipid transport;GO:0008203|cholesterol metabolic process;GO:0010900|negative regulation of phosphatidylcholine catabolic process;GO:0010916|negative regulation of very-low-density lipoprotein particle clearance;GO:0032368|regulation of lipid transport;GO:0032375|negative regulation of cholesterol transport;GO:0033344|cholesterol efflux;GO:0033700|phospholipid efflux;GO:0034369|plasma lipoprotein particle remodeling;GO:0034382|chylomicron remnant clearance;GO:0034447|very-low-density lipoprotein particle clearance;GO:0042157|lipoprotein metabolic process;GO:0045717|negative regulation of fatty acid biosynthetic process;GO:0045833|negative regulation of lipid metabolic process;GO:0048261|negative regulation of receptor-mediated endocytosis;GO:0050995|negative regulation of lipid catabolic process;GO:0051005|negative regulation of lipoprotein lipase activity;","GO:0005576|extracellular region;GO:0005783|endoplasmic reticulum;GO:0034361|very-low-density lipoprotein particle;GO:0034364|high-density lipoprotein particle;","GO:0003674|molecular_function;GO:0004859|phospholipase inhibitor activity;GO:0005504|fatty acid binding;GO:0055102|lipase inhibitor activity;","K22286","APOC1; apolipoprotein C-I"]
["ENSRNOG00000025251",45,2.894869718,12,0.774742316,3.736558155,1.901709976,{"v":7.01673e-06,"d":"7.02E-06"},{"v":5.41989e-06,"d":"5.42E-06"},"up","yes","H1f8","protein_coding","chr4:148993133-148998254:+","gi|157819381|ref|NP_001102821.1|",1499,0,"H1 histone family, member O, oocyte-specific [Rattus norvegicus]","gi|157819380|ref|NM_001109351.1|",1149,0,"Rattus norvegicus H1 histone family, member O, oocyte-specific (H1foo), mRNA","Q8VIK3",403,{"v":3e-138,"d":"3.00E-138"},"Histone H1oo",".",".",".",".","pfam00538","Linker_histone","linker histone H1 and H5 family. Linker histone H1 is an essential component of chromatin structure. H1 links nucleosomes into higher order structures Histone H1 is replaced by histone H5 in some cell types.","GO:0006334|nucleosome assembly;GO:0016584|nucleosome positioning;GO:0030261|chromosome condensation;GO:0044030|regulation of DNA methylation;GO:0045910|negative regulation of DNA recombination;GO:2000737|negative regulation of stem cell differentiation;","GO:0000786|nucleosome;GO:0001674|female germ cell nucleus;GO:0005634|nucleus;","GO:0003690|double-stranded DNA binding;GO:0031492|nucleosomal DNA binding;",".","."]
["ENSRNOG00000049882",20,1.286608764,1,0.06456186,19.92831016,4.316747476,{"v":7.66623E-6,"d":"7.67E-06"},{"v":5.89449e-06,"d":"5.89E-06"},"up","yes","Adcyap1","protein_coding","chr9:113103718-113109773:-","gi|8392855|ref|NP_058685.1|",920,{"v":8e-117,"d":"8.00E-117"},"pituitary adenylate cyclase-activating polypeptide precursor [Rattus norvegicus]","gi|205957|gb|M63006.1|RATPACAP",2092,0,"Rat pituitary adenylate cyclase activating polypeptide precursor protein mRNA, complete cds","P13589",358,{"v":3e-118,"d":"3.00E-118"},"Pituitary adenylate cyclase-activating polypeptide",".",".",".",".","pfam00123","Hormone_2","Peptide hormone. This family contains glucagon, GIP, secretin and VIP.","GO:0001541|ovarian follicle development;GO:0001662|behavioral fear response;GO:0001821|histamine secretion;GO:0001932|regulation of protein phosphorylation;GO:0002865|negative regulation of acute inflammatory response to antigenic stimulus;GO:0002878|negative regulation of acute inflammatory response to non-antigenic stimulus;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007218|neuropeptide signaling pathway;GO:0008277|regulation of G protein-coupled receptor signaling pathway;GO:0008284|positive regulation of cell proliferation;GO:0010628|positive regulation of gene expression;GO:0010656|negative regulation of muscle cell apoptotic process;GO:0010976|positive regulation of neuron projection development;GO:0019233|sensory perception of pain;GO:0019933|cAMP-mediated signaling;GO:0021983|pituitary gland development;GO:0030073|insulin secretion;GO:0031175|neuron projection development;GO:0032755|positive regulation of interleukin-6 production;GO:0032880|regulation of protein localization;GO:0034260|negative regulation of GTPase activity;GO:0042311|vasodilation;GO:0042594|response to starvation;GO:0043267|negative regulation of potassium ion transport;GO:0043547|positive regulation of GTPase activity;GO:0043950|positive regulation of cAMP-mediated signaling;GO:0045471|response to ethanol;GO:0045786|negative regulation of cell cycle;GO:0045860|positive regulation of protein kinase activity;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046034|ATP metabolic process;GO:0051968|positive regulation of synaptic transmission, glutamatergic;GO:0060078|regulation of postsynaptic membrane potential;GO:0060124|positive regulation of growth hormone secretion;GO:0060253|negative regulation of glial cell proliferation;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070445|regulation of oligodendrocyte progenitor proliferation;GO:0071385|cellular response to glucocorticoid stimulus;GO:0071651|positive regulation of chemokine (C-C motif) ligand 5 production;GO:0090274|positive regulation of somatostatin secretion;GO:0120162|positive regulation of cold-induced thermogenesis;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005829|cytosol;GO:0043005|neuron projection;GO:0043195|terminal bouton;GO:0043204|perikaryon;","GO:0005102|signaling receptor binding;GO:0005184|neuropeptide hormone activity;GO:0016521|pituitary adenylate cyclase activating polypeptide activity;GO:0031858|pituitary adenylate cyclase-activating polypeptide receptor binding;GO:0051428|peptide hormone receptor binding;","K05262","ADCYAP; pituitary adenylate cyclase-activating polypeptide"]
["ENSRNOG00000067701",20,1.286608764,1,0.06456186,19.92831016,4.316747476,{"v":7.66623E-6,"d":"7.67E-06"},{"v":5.89449e-06,"d":"5.89E-06"},"up","yes","ENSRNOG00000067701","lncRNA","chr4:161398170-161446081:-",".",".",".",".","gi|41237737|gb|AC119177.11|",334,{"v":2e-172,"d":"2.00E-172"},"Mus musculus chromosome 15, clone RP24-559L16, complete sequence",".",".",".",".",".",".",".",".","pfam05675","DUF817","Protein of unknown function (DUF817). This family consists of several bacterial proteins of unknown function.",".",".",".",".","."]
["ENSRNOG00000068516",59,3.795495853,20,1.291237193,2.939425749,1.555534335,{"v":7.87714e-06,"d":"7.88E-06"},{"v":6.05095e-06,"d":"6.05E-06"},"up","yes","Hist1h2ail1","protein_coding","chr17:41568471-41569109:-","gi|562869414|ref|XP_006162733.1|",715,{"v":4e-93,"d":"4.00E-93"},"PREDICTED: histone H3.1 [Tupaia chinensis]","gi|298889922|emb|FQ227095.1|",623,0,"Rattus norvegicus TL0AEA15YD03 mRNA sequence","Q6LED0",274,{"v":1e-92,"d":"1.00E-92"},"Histone H3.1",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.",".",".",".",".","."]
["ENSRNOG00000015797",52,3.345182786,16,1.032989754,3.238350401,1.695259099,{"v":8.10093e-06,"d":"8.10E-06"},{"v":6.21533E-6,"d":"6.22E-06"},"up","yes","Neurl2","protein_coding","chr3:153566660-153569380:-","gi|157821687|ref|NP_001101272.1|",1486,0,"neuralized-like protein 2 [Rattus norvegicus]","gi|442734429|ref|NM_001107802.2|",1456,0,"Rattus norvegicus neuralized E3 ubiquitin protein ligase 2 (Neurl2), mRNA","Q9D0S4",546,0,"Neuralized-like protein 2",".",".",".",".","pfam07177","Neuralized","Neuralized. This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.","GO:0008150|biological_process;GO:0016567|protein ubiquitination;GO:0030239|myofibril assembly;GO:0035556|intracellular signal transduction;GO:0045214|sarcomere organization;","GO:0005575|cellular_component;GO:0005927|muscle tendon junction;GO:0030891|VCB complex;","GO:0003674|molecular_function;GO:0061630|ubiquitin protein ligase activity;","K16782","NEURL2; neuralized-like protein 2"]
["ENSRNOG00000013260",115,7.398000391,57,3.680026,2.01031199,1.007419417,{"v":8.87591e-06,"d":"8.88E-06"},{"v":6.7924e-06,"d":"6.79E-06"},"up","yes","Calr3","protein_coding","chr16:17396247-17423015:+","gi|58866000|ref|NP_001012212.1|",1952,0,"calreticulin-3 precursor [Rattus norvegicus]","gi|58865999|ref|NM_001012212.1|",1213,0,"Rattus norvegicus calreticulin 3 (Calr3), mRNA","Q9D9Q6",726,0,"Calreticulin-3",".",".",".",".","pfam00262","Calreticulin","Calreticulin family.","GO:0006457|protein folding;GO:0030433|ubiquitin-dependent ERAD pathway;","GO:0005635|nuclear envelope;GO:0005788|endoplasmic reticulum lumen;GO:0005789|endoplasmic reticulum membrane;","GO:0044183|protein binding involved in protein folding;GO:0051082|unfolded protein binding;","K10098","CALR3; calreticulin 3"]
["ENSRNOG00000004778",30,1.929913146,5,0.322809298,5.978493048,2.579781881,{"v":9.64263e-06,"d":"9.64E-06"},{"v":7.3498e-06,"d":"7.35E-06"},"up","yes","Cnga1","protein_coding","chr14:35567125-35605065:+","gi|2493742|sp|Q62927.1|CNGA1_RAT",3096,0,"RecName: Full=cGMP-gated cation channel alpha-1; AltName: Full=Cyclic nucleotide-gated cation channel 1; AltName: Full=Cyclic nucleotide-gated channel alpha-1; Short=CNG channel alpha-1; Short=CNG-1; Short=CNG1; AltName: Full=Cyclic nucleotide-gated channel, photoreceptor; AltName: Full=Rod photoreceptor cGMP-gated channel subunit alpha","gi|16758253|ref|NM_053497.1|",2103,0,"Rattus norvegicus cyclic nucleotide gated channel alpha 1 (Cnga1), mRNA","Q62927",1174,0,"cGMP-gated cation channel alpha-1",".",".",".",".","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0007283|spermatogenesis;GO:0007601|visual perception;GO:0051480|regulation of cytosolic calcium ion concentration;GO:0051899|membrane depolarization;GO:0098655|cation transmembrane transport;","GO:0001750|photoreceptor outer segment;GO:0005737|cytoplasm;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0017071|intracellular cyclic nucleotide activated cation channel complex;GO:0042622|photoreceptor outer segment membrane;GO:0043195|terminal bouton;","GO:0005221|intracellular cyclic nucleotide activated cation channel activity;GO:0005222|intracellular cAMP-activated cation channel activity;GO:0005223|intracellular cGMP-activated cation channel activity;GO:0030553|cGMP binding;","K04948","CNGA1; cyclic nucleotide gated channel alpha 1"]
["ENSRNOG00000015403",30,1.929913146,5,0.322809298,5.978493048,2.579781881,{"v":9.64263e-06,"d":"9.64E-06"},{"v":7.3498e-06,"d":"7.35E-06"},"up","yes","Cd52","protein_coding","chr5:146319969-146321348:-","gi|149024204|gb|EDL80701.1|",210,{"v":1e-19,"d":"1.00E-19"},"CD52 antigen [Rattus norvegicus]","gi|158937237|ref|NM_013706.2|",141,{"v":3e-66,"d":"3.00E-66"},"Mus musculus CD52 antigen (Cd52), mRNA","Q63064",82.8,{"v":5e-20,"d":"5.00E-20"},"CAMPATH-1 antigen",".",".",".",".","pfam15116","CD52","CAMPATH-1 antigen.","GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0009617|response to bacterium;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0031225|anchored component of membrane;GO:0097225|sperm midpiece;",".","K06488","CD52; CDW52 antigen"]
["ENSRNOG00000042731",60,3.859826291,21,1.355799053,2.846901451,1.509392553,{"v":1.04503e-05,"d":"1.05E-05"},{"v":7.93576e-06,"d":"7.94E-06"},"up","yes","Slc25a18","protein_coding","chr4:154000990-154021372:+","gi|402744047|ref|NP_001037745.2|",1603,0,"mitochondrial glutamate carrier 2 [Rattus norvegicus]","gi|402744046|ref|NM_001044280.2|",1964,0,"Rattus norvegicus solute carrier family 25 (glutamate carrier), member 18 (Slc25a18), mRNA","Q505J6",622,0,"Mitochondrial glutamate carrier 2",".",".",".",".","pfam00153","Mito_carr","Mitochondrial carrier protein.","GO:0006810|transport;GO:0015810|aspartate transmembrane transport;GO:0015813|L-glutamate transmembrane transport;GO:0043490|malate-aspartate shuttle;GO:0070778|L-aspartate transmembrane transport;","GO:0005743|mitochondrial inner membrane;GO:0016021|integral component of membrane;","GO:0005313|L-glutamate transmembrane transporter activity;GO:0015183|L-aspartate transmembrane transporter activity;GO:0015293|symporter activity;GO:0022857|transmembrane transporter activity;","K15107","SLC25A18_22, GC; solute carrier family 25 (mitochondrial glutamate transporter), member 18/22"]
["ENSRNOG00000025957",103,6.626035133,49,3.163531123,2.094506068,1.066610064,{"v":1.05143E-5,"d":"1.05E-05"},{"v":7.9801E-6,"d":"7.98E-06"},"up","yes","Ooep","protein_coding","chr8:79223375-79224541:-","gi|149019093|gb|EDL77734.1|",815,{"v":5E-108,"d":"5.00E-108"},"rCG25286 [Rattus norvegicus]","gi|672023099|ref|XM_008757824.1|",671,0,"PREDICTED: Rattus norvegicus oocyte expressed protein (Ooep), mRNA","Q9CWE6",211,{"v":2e-67,"d":"2.00E-67"},"Oocyte-expressed protein homolog",".",".",".",".","pfam14356","DUF4403","Domain of unknown function (DUF4403). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 455 and 518 amino acids in length. There is a single completely conserved residue W that may be functionally important.","GO:0001701|in utero embryonic development;GO:0006468|protein phosphorylation;GO:0007015|actin filament organization;GO:0007566|embryo implantation;GO:0009566|fertilization;GO:0009880|embryonic pattern specification;GO:0010468|regulation of gene expression;GO:0031297|replication fork processing;GO:0032880|regulation of protein localization;GO:0034622|cellular protein-containing complex assembly;GO:0035088|establishment or maintenance of apical/basal cell polarity;GO:0045836|positive regulation of meiotic nuclear division;GO:0051293|establishment of spindle localization;GO:0051302|regulation of cell division;GO:0070201|regulation of establishment of protein localization;GO:1905168|positive regulation of double-strand break repair via homologous recombination;GO:2000781|positive regulation of double-strand break repair;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005938|cell cortex;GO:0032991|protein-containing complex;GO:0045177|apical part of cell;","GO:0003723|RNA binding;GO:0003729|mRNA binding;","K25077","OOEP; oocyte-expressed protein"]
["ENSRNOG00000055596",25,1.608260955,3,0.193685579,8.303462567,3.05371307,{"v":1.05989e-05,"d":"1.06E-05"},{"v":8.04327e-06,"d":"8.04E-06"},"up","yes","Csn1s1","protein_coding","chr14:20343619-20359614:-","gi|32306545|ref|NP_620229.2|",507,{"v":3e-56,"d":"3.00E-56"},"alpha-S1-casein precursor [Rattus norvegicus]","gi|32306544|ref|NM_138874.2|",650,0,"Rattus norvegicus casein alpha s1 (Csn1s1), mRNA","P02661",195,{"v":6e-56,"d":"6.00E-56"},"Alpha-S1-casein",".",".",".",".","pfam00363","Casein","Casein.","GO:0032355|response to estradiol;GO:0032570|response to progesterone;GO:1903494|response to dehydroepiandrosterone;GO:1903496|response to 11-deoxycorticosterone;","GO:0005576|extracellular region;GO:0005615|extracellular space;",".",".","."]
["ENSRNOG00000003476",97,6.240052504,45,2.905283684,2.147828984,1.102879127,{"v":1.1141e-05,"d":"1.11E-05"},{"v":8.43895e-06,"d":"8.44E-06"},"up","yes","Slc6a4","protein_coding","chr10:61826123-61858384:+","gi|77627875|ref|NP_037166.2|",3274,0,"sodium-dependent serotonin transporter [Rattus norvegicus]","gi|207086|gb|M79450.1|RATSTRP",2167,0,"Rat serotonin transporter mRNA, complete cds","P31652",1265,0,"Sodium-dependent serotonin transporter","VC2012",239,{"v":9e-69,"d":"9.00E-69"},"COG0733","pfam00209","SNF","Sodium:neurotransmitter symporter family.","GO:0001666|response to hypoxia;GO:0006836|neurotransmitter transport;GO:0006837|serotonin transport;GO:0007420|brain development;GO:0007584|response to nutrient;GO:0007613|memory;GO:0007623|circadian rhythm;GO:0007626|locomotory behavior;GO:0009410|response to xenobiotic stimulus;GO:0009636|response to toxic substance;GO:0010033|response to organic substance;GO:0010628|positive regulation of gene expression;GO:0014064|positive regulation of serotonin secretion;GO:0015844|monoamine transport;GO:0021941|negative regulation of cerebellar granule cell precursor proliferation;GO:0032227|negative regulation of synaptic transmission, dopaminergic;GO:0032355|response to estradiol;GO:0035176|social behavior;GO:0035725|sodium ion transmembrane transport;GO:0042310|vasoconstriction;GO:0042713|sperm ejaculation;GO:0045665|negative regulation of neuron differentiation;GO:0045787|positive regulation of cell cycle;GO:0046621|negative regulation of organ growth;GO:0048854|brain morphogenesis;GO:0051610|serotonin uptake;GO:0071300|cellular response to retinoic acid;GO:0071310|cellular response to organic substance;GO:0071321|cellular response to cGMP;GO:0090067|regulation of thalamus size;GO:0098810|neurotransmitter reuptake;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005925|focal adhesion;GO:0010008|endosome membrane;GO:0012505|endomembrane system;GO:0043005|neuron projection;GO:0045121|membrane raft;GO:0045202|synapse;GO:0099055|integral component of postsynaptic membrane;GO:0099056|integral component of presynaptic membrane;GO:0099154|serotonergic synapse;","GO:0005326|neurotransmitter transporter activity;GO:0005335|serotonin:sodium symporter activity;GO:0005515|protein binding;GO:0008504|monoamine transmembrane transporter activity;GO:0017075|syntaxin-1 binding;GO:0019811|cocaine binding;GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0050998|nitric-oxide synthase binding;GO:0051015|actin filament binding;GO:0051378|serotonin binding;","K05037","SLC6A4, SERT; solute carrier family 6 (neurotransmitter transporter, serotonin) member 4"]
["ENSRNOG00000007229",79,5.082104617,33,2.130541369,2.385358337,1.254206009,{"v":1.12034E-5,"d":"1.12E-05"},{"v":8.47276e-06,"d":"8.47E-06"},"up","yes","Nr0b2","protein_coding","chr5:145779294-145782609:+","gi|16930821|ref|NP_476474.1|",1273,{"v":1E-173,"d":"1.00E-173"},"nuclear receptor subfamily 0 group B member 2 [Rattus norvegicus]","gi|16930820|ref|NM_057133.1|",1111,0,"Rattus norvegicus nuclear receptor subfamily 0, group B, member 2 (Nr0b2), mRNA","P97947",494,{"v":4E-175,"d":"4.00E-175"},"Nuclear receptor subfamily 0 group B member 2",".",".",".",".","pfam00104","Hormone_recep","Ligand-binding domain of nuclear hormone receptor. This all helical domain is involved in binding the hormone in these receptors.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0007219|Notch signaling pathway;GO:0007623|circadian rhythm;GO:0009749|response to glucose;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0014070|response to organic cyclic compound;GO:0015721|bile acid and bile salt transport;GO:0031100|animal organ regeneration;GO:0032024|positive regulation of insulin secretion;GO:0032922|circadian regulation of gene expression;GO:0043433|negative regulation of DNA-binding transcription factor activity;GO:0045471|response to ethanol;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0032991|protein-containing complex;","GO:0003714|transcription corepressor activity;GO:0008134|transcription factor binding;GO:0019904|protein domain specific binding;GO:0042803|protein homodimerization activity;GO:0042974|retinoic acid receptor binding;GO:0042975|peroxisome proliferator activated receptor binding;GO:0044877|protein-containing complex binding;GO:0046965|retinoid X receptor binding;GO:0046966|thyroid hormone receptor binding;","K08563","NR0B2, SHP; nuclear receptor subfamily 0 group B member 2"]
["ENSRNOG00000020655",44,2.83053928,12,0.774742316,3.653523529,1.869288499,{"v":1.12398E-5,"d":"1.12E-05"},{"v":8.49916e-06,"d":"8.50E-06"},"up","yes","Ucn2","protein_coding","chr8:109638285-109639172:+","gi|254675174|ref|NP_596876.2|",360,{"v":3e-39,"d":"3.00E-39"},"urocortin-2 precursor [Rattus norvegicus]","gi|254675173|ref|NM_133385.2|",882,0,"Rattus norvegicus urocortin 2 (Ucn2), mRNA","Q91WW1",141,{"v":6e-40,"d":"6.00E-40"},"Urocortin-2",".",".",".",".","pfam11613","UCN2","Agonist of corticotropin releasing factor R2, Urocortin-2. This family of proteins represents urocortin 2, a member of the corticoliberin family which is a selective agnonist of corticotropin releasing factor 2. The backbone of the protein is mainly alpha-helical but it contains a helix-loop-helix motif.","GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007586|digestion;GO:0008283|cell proliferation;GO:0009755|hormone-mediated signaling pathway;GO:0010629|negative regulation of gene expression;GO:0031669|cellular response to nutrient levels;GO:0033685|negative regulation of luteinizing hormone secretion;GO:0035902|response to immobilization stress;GO:0042246|tissue regeneration;GO:0046882|negative regulation of follicle-stimulating hormone secretion;GO:0071385|cellular response to glucocorticoid stimulus;GO:0071456|cellular response to hypoxia;","GO:0005615|extracellular space;","GO:0001664|G protein-coupled receptor binding;GO:0005179|hormone activity;GO:0042562|hormone binding;GO:0051429|corticotropin-releasing hormone receptor binding;GO:0051431|corticotropin-releasing hormone receptor 2 binding;","K05257","UCN2_3; urocortin 2/3"]
["ENSRNOG00000012878",53,3.409513224,17,1.097551614,3.106471878,1.635276994,{"v":1.12724e-05,"d":"1.13E-05"},{"v":8.5204e-06,"d":"8.52E-06"},"up","yes","Atp7b","protein_coding","chr16:69951778-70023636:+","gi|564389728|ref|XP_006253408.1|",7593,0,"PREDICTED: copper-transporting ATPase 2 isoform X1 [Rattus norvegicus]","gi|672080488|ref|XM_006253346.2|",6182,0,"PREDICTED: Rattus norvegicus ATPase, Cu++ transporting, beta polypeptide (Atp7b), transcript variant X1, mRNA","Q64535",2794,0,"Copper-transporting ATPase 2","SA2344",605,0,"COG2217","pfam00122","E1-E2_ATPase","E1-E2 ATPase.","GO:0006825|copper ion transport;GO:0006878|cellular copper ion homeostasis;GO:0006882|cellular zinc ion homeostasis;GO:0007595|lactation;GO:0007623|circadian rhythm;GO:0010043|response to zinc ion;GO:0015677|copper ion import;GO:0015680|protein maturation by copper ion transfer;GO:0035434|copper ion transmembrane transport;GO:0046688|response to copper ion;GO:0051208|sequestering of calcium ion;GO:0051591|response to cAMP;GO:0055070|copper ion homeostasis;GO:0060003|copper ion export;GO:0071280|cellular response to copper ion;GO:0071287|cellular response to manganese ion;GO:1990637|response to prolactin;","GO:0005770|late endosome;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005802|trans-Golgi network;GO:0005886|plasma membrane;GO:0005923|bicellular tight junction;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0031410|cytoplasmic vesicle;GO:0032588|trans-Golgi network membrane;GO:0045177|apical part of cell;GO:0048471|perinuclear region of cytoplasm;GO:0070160|tight junction;","GO:0005375|copper ion transmembrane transporter activity;GO:0005507|copper ion binding;GO:0005524|ATP binding;GO:0008270|zinc ion binding;GO:0043682|copper-transporting ATPase activity;","K17686","copA, ctpA, ATP7; P-type Cu+ transporter [EC:7.2.2.8]"]
["ENSRNOG00000014960",94,6.047061189,43,2.776159965,2.178210645,1.123143478,{"v":1.13712E-5,"d":"1.14E-05"},{"v":8.58827E-6,"d":"8.59E-06"},"up","yes","Bard1","protein_coding","chr9:72623155-72694265:-","gi|149015988|gb|EDL75269.1|",3422,0,"BRCA1 associated RING domain 1 [Rattus norvegicus]","gi|12018307|ref|NM_022622.1|",2230,0,"Rattus norvegicus BRCA1 associated RING domain 1 (Bard1), mRNA","Q9QZH2",1319,0,"BRCA1-associated RING domain protein 1",".",".",".",".","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0006281|DNA repair;GO:0007283|spermatogenesis;GO:0042325|regulation of phosphorylation;GO:0043065|positive regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0046826|negative regulation of protein export from nucleus;GO:0085020|protein K6-linked ubiquitination;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0016607|nuclear speck;GO:0031436|BRCA1-BARD1 complex;GO:0036464|cytoplasmic ribonucleoprotein granule;GO:0070531|BRCA1-A complex;","GO:0003674|molecular_function;GO:0003723|RNA binding;GO:0004842|ubiquitin-protein transferase activity;GO:0042803|protein homodimerization activity;GO:0046872|metal ion binding;GO:0046982|protein heterodimerization activity;","K10683","BARD1; BRCA1-associated RING domain protein 1"]
["ENSRNOG00000004939",51,3.280852347,16,1.032989754,3.176074432,1.667244723,{"v":1.25676E-5,"d":"1.26E-05"},{"v":9.45682e-06,"d":"9.46E-06"},"up","yes","Ttll6","protein_coding","chr10:81091975-81127234:+","gi|672025198|ref|XP_008773524.1|",3417,0,"PREDICTED: tubulin polyglutamylase TTLL6-like [Rattus norvegicus]","gi|672025199|ref|XM_008775303.1|",1674,0,"PREDICTED: Rattus norvegicus tubulin tyrosine ligase-like family, member 6 (Ttll6), transcript variant X3, mRNA","A4Q9E8",1298,0,"Tubulin polyglutamylase TTLL6",".",".",".",".","pfam03133","TTL","Tubulin-tyrosine ligase family. Tubulins and microtubules are subjected to several post-translational modifications of which the reversible detyrosination/tyrosination of the carboxy-terminal end of most alpha-tubulins has been extensively analysed. This modification cycle involves a specific carboxypeptidase and the activity of the tubulin-tyrosine ligase (TTL). The true physiological function of TTL has so far not been established. Tubulin-tyrosine ligase (TTL) catalyses the ATP-dependent post-translational addition of a tyrosine to the carboxy terminal end of detyrosinated alpha-tubulin. In normally cycling cells, the tyrosinated form of tubulin predominates. However, in breast cancer cells, the detyrosinated form frequently predominates, with a correlation to tumor aggressiveness. On the other hand, 3-nitrotyrosine has been shown to be incorporated, by TTL, into the carboxy terminal end of detyrosinated alpha-tubulin. This reaction is not reversible by the carboxypeptidase enzyme. Cells cultured in 3-nitrotyrosine rich medium showed evidence of altered microtubule structure and function, including altered cell morphology, epithelial barrier dysfunction, and apoptosis. Bacterial homologs of TTL are predicted to form peptide tags. Some of these are fused to a 2-oxoglutarate Fe(II)-dependent dioxygenase domain.","GO:0000226|microtubule cytoskeleton organization;GO:0001578|microtubule bundle formation;GO:0003353|positive regulation of cilium movement;GO:0018095|protein polyglutamylation;GO:0051013|microtubule severing;","GO:0005929|cilium;GO:0036064|ciliary basal body;GO:0097731|9+0 non-motile cilium;","GO:0015631|tubulin binding;GO:0070739|protein-glutamic acid ligase activity;GO:0070740|tubulin-glutamic acid ligase activity;","K16582","TTLL6_13; tubulin polyglutamylase TTLL6/13 [EC:6.3.2.61]"]
["ENSRNOG00000048187",56,3.602504538,19,1.226675333,2.936803602,1.554246789,{"v":1.35657E-5,"d":"1.36E-05"},{"v":1.01797E-5,"d":"1.02E-05"},"up","yes","Epop","protein_coding","chr10:82624392-82625912:-","gi|157820061|ref|NP_001103097.1|",1268,{"v":8e-169,"d":"8.00E-169"},"uncharacterized protein C17orf96 homolog [Rattus norvegicus]","gi|157820060|ref|NM_001109627.1|",1521,0,"Rattus norvegicus hypothetical protein LOC691153 (LOC691153), mRNA","Q7TNS8",407,{"v":5E-137,"d":"5.00E-137"},"Elongin BC and Polycomb repressive complex 2-associated protein",".",".",".",".","pfam15223","DUF4584","Domain of unknown function (DUF4584). This family of proteins is found in eukaryotes. Proteins in this family are approximately 835 amino acids in length. The family is found in association with pfam02437.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0035616|histone H2B conserved C-terminal lysine deubiquitination;GO:0048663|neuron fate commitment;GO:0048863|stem cell differentiation;","GO:0035098|ESC/E(Z) complex;GO:0070449|elongin complex;","GO:0003682|chromatin binding;",".","."]
["ENSRNOG00000027916",19,1.222278326,1,0.06456186,18.93189465,4.242746894,{"v":1.41471E-5,"d":"1.41E-05"},{"v":1.06007E-5,"d":"1.06E-05"},"up","yes","Txndc2","protein_coding","chr9:105230578-105235126:-","gi|225579141|ref|NP_001139476.1|",2828,0,"thioredoxin domain-containing protein 2 isoform 1 [Rattus norvegicus]","gi|225579140|ref|NM_001146004.1|",1783,0,"Rattus norvegicus thioredoxin domain containing 2 (spermatozoa) (Txndc2), transcript variant 1, mRNA","Q5XHX6",1093,0,"Thioredoxin domain-containing protein 2","SPAC7D4.07c",81.3,{"v":3e-17,"d":"3.00E-17"},"COG0526","pfam00085","Thioredoxin","Thioredoxin. Thioredoxins are small enzymes that participate in redox reactions, via the reversible oxidation of an active centre disulfide bond. Some members with only the active site are not separated from the noise.","GO:0007283|spermatogenesis;GO:0030154|cell differentiation;GO:0030317|flagellated sperm motility;GO:0034614|cellular response to reactive oxygen species;GO:0098869|cellular oxidant detoxification;","GO:0001520|outer dense fiber;GO:0005737|cytoplasm;GO:0036126|sperm flagellum;","GO:0003756|protein disulfide isomerase activity;GO:0004791|thioredoxin-disulfide reductase activity;",".","."]
["ENSRNOG00000042716",19,1.222278326,1,0.06456186,18.93189465,4.242746894,{"v":1.41471E-5,"d":"1.41E-05"},{"v":1.06007E-5,"d":"1.06E-05"},"up","yes","RGD1562699","protein_coding","chr18:57827117-57827989:-","gi|564393782|ref|XP_006254908.1|",365,{"v":2E-41,"d":"2.00E-41"},"PREDICTED: uncharacterized protein LOC291558 isoform X1 [Rattus norvegicus]","gi|672083370|ref|XM_008772122.1|",389,0,"PREDICTED: Rattus norvegicus RGD1562699 (RGD1562699), transcript variant X6, mRNA",".",".",".",".",".",".",".",".","pfam01927","Mut7-C","Mut7-C RNAse domain. RNAse domain of the PIN fold with an inserted Zinc Ribbon at the C terminus.",".",".",".",".","."]
["ENSRNOG00000016505",99,6.36871338,47,3.034407404,2.098832666,1.069587149,{"v":1.4929e-05,"d":"1.49E-05"},{"v":1.11734E-5,"d":"1.12E-05"},"up","yes","Fam169a","protein_coding","chr2:28383784-28438910:+","gi|564299653|ref|XP_006224049.1|",2980,0,"PREDICTED: soluble lamin-associated protein of 75 kDa isoform X1 [Rattus norvegicus]","gi|672041296|ref|XM_006231831.2|",2455,0,"PREDICTED: Rattus norvegicus family with sequence similarity 169, member A (Fam169a), transcript variant X1, mRNA","Q5XG69",1018,0,"Soluble lamin-associated protein of 75 kDa",".",".",".",".","pfam07223","DUF1421","Protein of unknown function (DUF1421). This family represents a conserved region approximately 350 residues long within a number of plant proteins of unknown function.",".",".",".",".","."]
["ENSRNOG00000032664",62,3.988487167,23,1.484922772,2.68598963,1.425453735,{"v":1.76012E-5,"d":"1.76E-05"},{"v":1.31133E-5,"d":"1.31E-05"},"up","yes","RT1-S2","protein_coding","chr20:2649964-2652027:+","gi|57012392|ref|NP_001008857.1|",763,{"v":2e-97,"d":"2.00E-97"},"RT1 class Ib, locus S2 precursor [Rattus norvegicus]","gi|672085586|ref|XM_008772705.1|",804,0,"PREDICTED: Rattus norvegicus RT1 class Ib, locus S2 (RT1-S2), transcript variant X1, mRNA","P01896",190,{"v":9e-57,"d":"9.00E-57"},"H-2 class I histocompatibility antigen, alpha chain (Fragment)",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.",".",".",".","K06751","MHC1; MHC class I antigen"]
["ENSRNOG00000062668",57,3.666834977,20,1.291237193,2.839784198,1.5057813,{"v":1.79932e-05,"d":"1.80E-05"},{"v":1.33913E-5,"d":"1.34E-05"},"up","yes","ENSRNOG00000062668","lncRNA","chr1:83268461-83272734:-","gi|149056493|gb|EDM07924.1|",171,{"v":1e-11,"d":"1.00E-11"},"rCG53654 [Rattus norvegicus]","gi|672013290|ref|XR_342821.2|",529,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102549611 (LOC102549611), transcript variant X1, ncRNA",".",".",".",".",".",".",".",".","pfam04529","Herpes_U59","Herpesvirus U59 protein. The proteins in this family have no known function. Cytomegalovirus UL88 is also a member of this family.",".",".",".",".","."]
["ENSRNOG00000011357",73,4.696121987,30,1.93685579,2.424611069,1.277753344,{"v":1.834e-05,"d":"1.83E-05"},{"v":1.36369E-5,"d":"1.36E-05"},"up","yes","Shbg","protein_coding","chr10:54332941-54351057:-","gi|672067694|ref|XP_008765993.1|",1936,0,"PREDICTED: sex hormone-binding globulin isoform X2 [Rattus norvegicus]","gi|672067693|ref|XM_008767771.1|",1422,0,"PREDICTED: Rattus norvegicus sex hormone binding globulin (Shbg), transcript variant X2, mRNA","P08689",659,0,"Sex hormone-binding globulin",".",".",".",".","pfam00054","Laminin_G_1","Laminin G domain.","GO:0007285|primary spermatocyte growth;","GO:0005615|extracellular space;","GO:0005496|steroid binding;GO:0005515|protein binding;",".","."]
["ENSRNOG00000026162",104,6.690365571,51,3.292654842,2.031906134,1.022833757,{"v":1.88355e-05,"d":"1.88E-05"},{"v":1.39908E-5,"d":"1.40E-05"},"up","yes","Cetn4","protein_coding","chr2:120199942-120203348:-","gi|403043600|ref|NP_001258080.1|",851,{"v":3e-111,"d":"3.00E-111"},"centrin 4 [Rattus norvegicus]","gi|403043599|ref|NM_001271151.1|",1016,0,"Rattus norvegicus centrin 4 (Cetn4), mRNA","Q8K4K1",323,{"v":4E-109,"d":"4.00E-109"},"Centrin-4","YOR257w",151,{"v":5e-43,"d":"5.00E-43"},"COG5126","pfam13499","EF-hand_7","EF-hand domain pair.","GO:0000278|mitotic cell cycle;GO:0007099|centriole replication;","GO:0005813|centrosome;GO:0005814|centriole;GO:0036064|ciliary basal body;","GO:0005509|calcium ion binding;GO:0031683|G-protein beta/gamma-subunit complex binding;GO:0032795|heterotrimeric G-protein binding;","K25390","CETN4; centrin-4"]
["ENSRNOG00000063680",65,4.181478482,25,1.614046491,2.590680321,1.373331004,{"v":1.9229e-05,"d":"1.92E-05"},{"v":1.42701e-05,"d":"1.43E-05"},"up","yes","ENSRNOG00000063680","lncRNA","chr10:91012772-91015516:-","gi|149022070|gb|EDL78964.1|",138,1e-06,"rCG27106 [Rattus norvegicus]","gi|354793352|gb|JN957853.1|",346,{"v":4e-179,"d":"4.00E-179"},"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Taco1:tm1e(EUCOMM)Hmgu; transgenic",".",".",".",".",".",".",".",".","pfam10277","Frag1","Frag1/DRAM/Sfk1 family. This family includes Frag1, DRAM and Sfk1 proteins. Frag1 (FGF receptor activating protein 1) is a protein that is conserved from fungi to humans. There are four potential iso-prenylation sites throughout the peptide, viz CILW, CIIW and CIGL. Frag1 is a membrane-spanning protein that is ubiquitously expressed in adult tissues suggesting an important cellular function. Dram is a family of proteins conserved from nematodes to humans with six hydrophobic transmembrane regions and an Endoplasmic Reticulum signal peptide. It is a lysosomal protein that induces macro-autophagy as an effector of p53-mediated death, where p53 is the tumor-suppressor gene that is frequently mutated in cancer. Expression of Dram is stress-induced. This region is also part of a family of small plasma membrane proteins, referred to as Sfk1, that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, thus allowing proper localisation of Stt4p to the actin cytoskeleton.",".",".",".",".","."]
["ENSRNOG00000031665",101,6.497374257,49,3.163531123,2.053836047,1.038321019,{"v":1.96813e-05,"d":"1.97E-05"},{"v":1.45906e-05,"d":"1.46E-05"},"up","yes","ENSRNOG00000031665","protein_coding","chrX:30293589-30340977:-","gi|58865588|ref|NP_001012006.1|",4081,0,"angiotensin-converting enzyme 2 precursor [Rattus norvegicus]","gi|194473666|ref|NM_001130513.1|",2590,0,"Mus musculus angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (Ace2), transcript variant 1, mRNA","Q5EGZ1",1576,0,"Angiotensin-converting enzyme 2",".",".",".",".","pfam01401","Peptidase_M2","Angiotensin-converting enzyme. Members of this family are dipeptidyl carboxydipeptidases (cleave carboxyl dipeptides) and most notably convert angiotensin I to angiotensin II. Many members of this family contain a tandem duplication of the 600 amino acid peptidase domain, both of these are catalytically active. Most members are secreted membrane bound ectoenzymes.","GO:0003051|angiotensin-mediated drinking behavior;GO:0003081|regulation of systemic arterial blood pressure by renin-angiotensin;GO:0006508|proteolysis;GO:0015827|tryptophan transport;GO:0022898|regulation of transmembrane transporter activity;GO:0046718|viral entry into host cell;GO:0046813|receptor-mediated virion attachment to host cell;GO:0048662|negative regulation of smooth muscle cell proliferation;GO:0051957|positive regulation of amino acid transport;GO:0060135|maternal process involved in female pregnancy;GO:0060452|positive regulation of cardiac muscle contraction;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:1903598|positive regulation of gap junction assembly;GO:1903779|regulation of cardiac conduction;GO:1905737|positive regulation of L-proline import across plasma membrane;GO:2000272|negative regulation of signaling receptor activity;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005929|cilium;GO:0009986|cell surface;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0031526|brush border membrane;","GO:0001618|virus receptor activity;GO:0004175|endopeptidase activity;GO:0004180|carboxypeptidase activity;GO:0004181|metallocarboxypeptidase activity;GO:0005515|protein binding;GO:0008237|metallopeptidase activity;GO:0008241|peptidyl-dipeptidase activity;GO:0042802|identical protein binding;GO:0046872|metal ion binding;","K09708","ACE2, ACEH; angiotensin-converting enzyme 2 [EC:3.4.17.23]"]
["ENSRNOG00000018167",33,2.12290446,7,0.451933018,4.697387395,2.231858578,{"v":2.0024E-5,"d":"2.00E-05"},{"v":1.48389e-05,"d":"1.48E-05"},"up","yes","Tmem221","protein_coding","chr16:18262052-18266967:-","gi|392333550|ref|XP_003752924.1|",582,{"v":7e-67,"d":"7.00E-67"},"PREDICTED: transmembrane protein 221 isoform X2 [Rattus norvegicus]","gi|672079940|ref|XM_002728393.4|",1908,0,"PREDICTED: Rattus norvegicus transmembrane protein 221 (Tmem221), transcript variant X2, mRNA","Q8K071",212,{"v":3e-62,"d":"3.00E-62"},"Transmembrane protein 221",".",".",".",".","pfam15038","Jiraiya","Jiraiya. Jiraiya inhibits bone morphogenetic protein (BMP) signaling during embryogenesis. The human member of this family is TMEM221.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000051630",17,1.093617449,0,0.03228093,33.87812727,5.082282222,{"v":2.10658e-05,"d":"2.11E-05"},{"v":1.55705e-05,"d":"1.56E-05"},"up","yes","AABR07069587.2","lncRNA","chr8:29911090-29977779:+",".",".",".",".","gi|77020636|gb|AC167244.2|",158,{"v":4e-75,"d":"4.00E-75"},"Mus musculus BAC clone RP24-84C23 from chromosome 9, complete sequence",".",".",".",".",".",".",".",".","pfam00003","7tm_3","7 transmembrane sweet-taste receptor of 3 GCPR. This is a domain of seven transmembrane regions that forms the C-terminus of some subclass 3 G-coupled-protein receptors. It is often associated with a downstream cysteine-rich linker domain, NCD3G pfam07562, which is the human sweet-taste receptor, and the N-terminal domain, ANF_receptor pfam01094. The seven TM regions assemble in such a way as to produce a docking pocket into which such molecules as cyclamate and lactisole have been found to bind and consequently confer the taste of sweetness.",".",".",".",".","."]
["ENSRNOG00000070558",71,4.567461111,29,1.87229393,2.439500037,1.286585505,{"v":2.15879E-5,"d":"2.16E-05"},{"v":1.59378e-05,"d":"1.59E-05"},"up","yes","ENSRNOG00000070558","protein_coding","chr15:36677527-36701211:-","gi|568900759|ref|XP_006543249.1|",1599,0,"PREDICTED: uncharacterized protein Gm4131 [Mus musculus]","gi|672078538|ref|XM_006252194.2|",1631,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102554746 (LOC102554746), mRNA",".",".",".",".",".",".",".",".","pfam03925","SeqA","SeqA protein. The binding of SeqA protein to hemimethylated GATC sequences is important in the negative modulation of chromosomal initiation at oriC, and in the formation of SeqA foci necessary for Escherichia coli chromosome segregation. SeqA tetramers are able to aggregate or multimerize in a reversible, concentration-dependent manner. Apart from its function in the control of DNA replication, SeqA may also be a specific transcription factor.",".",".",".",".","."]
["ENSRNOG00000016672",46,2.959200157,14,0.903866035,3.273936669,1.711026415,{"v":2.39327e-05,"d":"2.39E-05"},{"v":1.76075E-5,"d":"1.76E-05"},"up","yes","Fam217a","protein_coding","chr17:29966651-29981455:+","gi|568982056|ref|XP_006516846.1|",2586,0,"PREDICTED: protein FAM217A isoform X2 [Mus musculus]","gi|402747040|ref|NM_001271083.1|",1876,0,"Rattus norvegicus family with sequence similarity 217, member A (Fam217a), mRNA",".",".",".",".",".",".",".",".","pfam15344","FAM217","FAM217 family. This family of proteins is found in eukaryotes. Proteins in this family are typically between 329 and 507 amino acids in length. There is a conserved YPDFLP sequence motif.",".",".",".",".","."]
["ENSRNOG00000062590",26,1.672591393,4,0.258247439,6.476700802,2.695259099,{"v":2.45808E-5,"d":"2.46E-05"},{"v":1.8075e-05,"d":"1.81E-05"},"up","yes","ENSRNOG00000062590","protein_coding","chr9:10025210-10085199:+","gi|564324403|ref|XP_006227191.1|",698,{"v":2e-81,"d":"2.00E-81"},"PREDICTED: disks large homolog 5-like [Rattus norvegicus]","gi|50925914|gb|BC079433.1|",1164,0,"Rattus norvegicus similar to RIKEN cDNA 4930555G01, mRNA (cDNA clone IMAGE:7115184)",".",".",".",".",".",".",".",".","pfam04822","Takusan","Takusan. This domain is named takusan, which is a Japanese word meaning 'many'. Members of this family regulate synaptic activity.",".",".",".",".","."]
["ENSRNOG00000053820",103,6.626035133,51,3.292654842,2.012368575,1.008894566,{"v":2.55619E-5,"d":"2.56E-05"},{"v":1.87698e-05,"d":"1.88E-05"},"up","yes","Zcwpw2","protein_coding","chr8:117681238-117773739:-","gi|672023431|ref|XP_008756103.1|",1742,0,"PREDICTED: zinc finger CW-type PWWP domain protein 2 isoform X2 [Rattus norvegicus]","gi|672023430|ref|XM_008757881.1|",1537,0,"PREDICTED: Rattus norvegicus zinc finger, CW type with PWWP domain 2 (Zcwpw2), transcript variant X2, mRNA","Q504Y3",364,{"v":9e-117,"d":"9.00E-117"},"Zinc finger CW-type PWWP domain protein 2",".",".",".",".","pfam07496","zf-CW","CW-type Zinc Finger. This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a \"highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development.\" Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteristic of vertebrates, higher plants and other animals in which these domain is found.",".",".","GO:0008270|zinc ion binding;GO:0035064|methylated histone binding;","K24690","ZCWPW2; zinc finger CW-type PWWP domain protein 2"]
["ENSRNOG00000029841",18,1.157947887,1,0.06456186,17.93547914,4.164744382,{"v":2.61626e-05,"d":"2.62E-05"},{"v":1.91912E-5,"d":"1.92E-05"},"up","yes","Cdh19","protein_coding","chr13:27936668-28019310:-","gi|57222296|ref|NP_001009448.1|",3818,0,"cadherin-19 precursor [Rattus norvegicus]","gi|672073793|ref|XM_006249653.2|",1754,0,"PREDICTED: Rattus norvegicus cadherin 19, type 2 (Cdh19), transcript variant X1, mRNA","Q9H159",1132,0,"Cadherin-19",".",".",".",".","pfam01049","Cadherin_C","Cadherin cytoplasmic region. Cadherins are vital in cell-cell adhesion during tissue differentiation. Cadherins are linked to the cytoskeleton by catenins. Catenins bind to the cytoplasmic tail of the cadherin. Cadherins cluster to form foci of homophilic binding units. A key determinant to the strength of the binding that it is mediated by cadherins is the juxtamembrane region of the cadherin. This region induces clustering and also binds to the protein p120ctn.","GO:0000902|cell morphogenesis;GO:0007043|cell-cell junction assembly;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007275|multicellular organism development;GO:0016339|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0034332|adherens junction organization;GO:0098742|cell-cell adhesion via plasma-membrane adhesion molecules;","GO:0005912|adherens junction;GO:0016021|integral component of membrane;GO:0016342|catenin complex;","GO:0005509|calcium ion binding;GO:0045296|cadherin binding;","K06806","CDH19; cadherin 19, type 2"]
["ENSRNOG00000064970",51,3.280852347,17,1.097551614,2.989246524,1.579781881,{"v":2.65053e-05,"d":"2.65E-05"},{"v":1.94351E-5,"d":"1.94E-05"},"up","yes","Zfp939","protein_coding","chr1:91128294-91140943:+","gi|564297297|ref|XP_006223276.1|",2972,0,"PREDICTED: zinc finger protein OZF-like isoform X1 [Rattus norvegicus]","gi|672036623|ref|XM_006228931.2|",2587,0,"PREDICTED: Rattus norvegicus zinc finger protein 939 (Zfp939), transcript variant X1, mRNA","Q96RE9",469,{"v":2E-149,"d":"2.00E-149"},"Zinc finger protein 300",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000025638",84,5.403756808,38,2.453350667,2.202602702,1.13920929,{"v":2.70568e-05,"d":"2.71E-05"},{"v":1.9814E-5,"d":"1.98E-05"},"up","yes","Npm2","protein_coding","chr15:45722400-45729726:-","gi|42714644|ref|NP_976085.1|",775,{"v":2E-100,"d":"2.00E-100"},"nucleoplasmin-2 [Rattus norvegicus]","gi|672078571|ref|XM_006252261.2|",673,0,"PREDICTED: Rattus norvegicus nucleophosmin/nucleoplasmin 2 (Npm2), transcript variant X1, mRNA","Q80W85",262,{"v":3e-86,"d":"3.00E-86"},"Nucleoplasmin-2",".",".",".",".","pfam03066","Nucleoplasmin","Nucleoplasmin. Nucleoplasmins are also known as chromatin decondensation proteins. They bind to core histones and transfer DNA to them in a reaction that requires ATP. This is thought to play a role in the assembly of regular nucleosomal arrays.","GO:0001824|blastocyst development;GO:0006338|chromatin remodeling;GO:0007096|regulation of exit from mitosis;GO:0007338|single fertilization;GO:0009994|oocyte differentiation;GO:0043085|positive regulation of catalytic activity;GO:0045740|positive regulation of DNA replication;GO:0045836|positive regulation of meiotic nuclear division;GO:0051054|positive regulation of DNA metabolic process;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;","GO:0003682|chromatin binding;GO:0003723|RNA binding;GO:0019899|enzyme binding;GO:0042393|histone binding;GO:0042802|identical protein binding;","K11277","NPM2; nucleophosmin 2"]
["ENSRNOG00000009897",97,6.240052504,47,3.034407404,2.056432006,1.040143371,{"v":2.80044e-05,"d":"2.80E-05"},{"v":2.04712e-05,"d":"2.05E-05"},"up","yes","Clcnkb","protein_coding","chr5:153710094-153732153:-","gi|564353904|ref|XP_006239382.1|",2633,0,"PREDICTED: chloride channel protein ClC-Kb isoform X1 [Rattus norvegicus]","gi|90819596|gb|DQ437671.1|",2303,0,"Rattus norvegicus ClC-K2a (Clck2) mRNA, complete cds, alternatively spliced","P51802",1017,0,"Chloride channel protein ClC-Kb",".",".",".",".","pfam00654","Voltage_CLC","Voltage gated chloride channel. This family of ion channels contains 10 or 12 transmembrane helices. Each protein forms a single pore. It has been shown that some members of this family form homodimers. In terms of primary structure, they are unrelated to known cation channels or other types of anion channels. Three ClC subfamilies are found in animals. ClC-1 is involved in setting and restoring the resting membrane potential of skeletal muscle, while other channels play important parts in solute concentration mechanisms in the kidney. These proteins contain two pfam00571 domains.","GO:0006821|chloride transport;GO:0030321|transepithelial chloride transport;GO:0034220|ion transmembrane transport;GO:0034765|regulation of ion transmembrane transport;","GO:0000139|Golgi membrane;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;GO:0034707|chloride channel complex;","GO:0005247|voltage-gated chloride channel activity;GO:0005254|chloride channel activity;GO:0046872|metal ion binding;","K05018","CLCNKB; chloride channel Kb"]
["ENSRNOG00000039183",97,6.240052504,47,3.034407404,2.056432006,1.040143371,{"v":2.80044e-05,"d":"2.80E-05"},{"v":2.04712e-05,"d":"2.05E-05"},"up","yes","Cip2a","protein_coding","chr11:51795024-51822938:-","gi|109493232|ref|XP_340983.3|",4435,0,"PREDICTED: protein CIP2A [Rattus norvegicus]","gi|672071002|ref|XM_340982.7|",3432,0,"PREDICTED: Rattus norvegicus similar to RIKEN cDNA C330027C09 (RGD1310335), mRNA","Q8BWY9",1615,0,"Protein CIP2A",".",".",".",".","pfam02463","SMC_N","RecF/RecN/SMC N terminal domain. This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics.   This family also includes the RecF and RecN proteins that are involved in DNA metabolizm and recombination.","GO:0007283|spermatogenesis;GO:2000179|positive regulation of neural precursor cell proliferation;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0042803|protein homodimerization activity;",".","."]
["ENSRNOG00000068121",64,4.117148044,25,1.614046491,2.5508237,1.350963191,{"v":2.81684E-5,"d":"2.82E-05"},{"v":2.05859e-05,"d":"2.06E-05"},"up","yes","ENSRNOG00000068121","lncRNA","chr18:30489217-30568888:+","gi|672083161|ref|XP_008770290.1|",574,{"v":1e-63,"d":"1.00E-63"},"PREDICTED: rho GTPase-activating protein 26 isoform X1 [Rattus norvegicus]","gi|672083160|ref|XM_008772068.1|",442,0,"PREDICTED: Rattus norvegicus Rho GTPase activating protein 26 (Arhgap26), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam06248","Zw10","Centromere/kinetochore Zw10. Zw10 and rough deal proteins are both required for correct metaphase check-pointing during mitosis. These proteins bind to the centromere/kinetochore.",".",".",".",".","."]
["ENSRNOG00000069710",40,2.573217527,11,0.710180456,3.62332912,1.857315857,{"v":3.05577e-05,"d":"3.06E-05"},{"v":2.22835e-05,"d":"2.23E-05"},"up","yes","Nat8f2","protein_coding","chr4:118319988-118324395:-","gi|291045290|ref|NP_001166920.1|",1195,{"v":5e-157,"d":"5.00E-157"},"probable N-acetyltransferase CML2 [Rattus norvegicus]","gi|672050328|ref|XM_006236801.2|",2010,0,"PREDICTED: Rattus norvegicus probable N-acetyltransferase CML2-like (LOC100910829), transcript variant X3, mRNA","P85118",462,{"v":1e-157,"d":"1.00E-157"},"N-acetyltransferase family 8 member 2",".",".",".",".","pfam00583","Acetyltransf_1","Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.",".",".",".",".","."]
["ENSRNOG00000068010",47,3.023530595,15,0.968427895,3.122101925,1.642517637,{"v":3.34976e-05,"d":"3.35E-05"},{"v":2.43342e-05,"d":"2.43E-05"},"up","yes","Myh8","protein_coding","chr10:51963510-51993232:+","gi|281604096|ref|NP_001093955.1|",9288,0,"myosin-8 [Rattus norvegicus]","gi|281604095|ref|NM_001100485.1|",6026,0,"Rattus norvegicus myosin, heavy chain 8, skeletal muscle, perinatal (Myh8), mRNA","P13542",3559,0,"Myosin-8","SPCC645.05c",747,0,"COG5022","pfam01576","Myosin_tail_1","Myosin tail. The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.",".",".",".",".","."]
["ENSRNOG00000011011",36,2.315895775,9,0.581056737,3.985662032,1.994819381,{"v":3.35222e-05,"d":"3.35E-05"},{"v":2.43459E-5,"d":"2.43E-05"},"up","yes","Nmb","protein_coding","chr1:134869446-134872190:-","gi|157820747|ref|NP_001102619.1|",495,{"v":3e-60,"d":"3.00E-60"},"neuromedin-B precursor [Rattus norvegicus]","gi|157820746|ref|NM_001109149.1|",660,0,"Rattus norvegicus neuromedin B (Nmb), mRNA","Q9CR53",176,{"v":2e-54,"d":"2.00E-54"},"Neuromedin-B",".",".",".",".","pfam05109","Herpes_BLLF1","Herpes virus major outer envelope glycoprotein (BLLF1). This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralizing antibodies in vivo.","GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007218|neuropeptide signaling pathway;GO:0008284|positive regulation of cell proliferation;GO:0042593|glucose homeostasis;GO:0046887|positive regulation of hormone secretion;GO:0046888|negative regulation of hormone secretion;GO:0050482|arachidonic acid secretion;","GO:0005576|extracellular region;GO:0043005|neuron projection;","GO:0005184|neuropeptide hormone activity;GO:0031710|neuromedin B receptor binding;","K05223","NMB; neuromedin B"]
["ENSRNOG00000068360",36,2.315895775,9,0.581056737,3.985662032,1.994819381,{"v":3.35222e-05,"d":"3.35E-05"},{"v":2.43459E-5,"d":"2.43E-05"},"up","yes","ENSRNOG00000068360","lncRNA","chr3:117805072-117806295:+",".",".",".",".","gi|354790020|gb|JN954521.1|",442,0,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Ubox5:tm1e(EUCOMM)Hmgu; transgenic",".",".",".",".",".",".",".",".","pfam15242","FAM53","Family of FAM53. The FAM53 protein family refers to a family of proteins, which bind to a transcriptional regulator that modulates cell proliferation. It is known to be highly important in neural tube development. It is found in eukaryotes and is typically between 303 and 413 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000017159",23,1.479600078,3,0.193685579,7.639185561,2.933418836,{"v":3.41619e-05,"d":"3.42E-05"},{"v":2.47947e-05,"d":"2.48E-05"},"up","yes","Dsc3","protein_coding","chr18:11377347-11413797:-","gi|157823393|ref|NP_001100872.1|",4809,0,"desmocollin-3 [Rattus norvegicus]","gi|133778946|ref|NM_007882.3|",3235,0,"Mus musculus desmocollin 3 (Dsc3), transcript variant 1, mRNA","P55850",1729,0,"Desmocollin-3",".",".",".",".","pfam01049","Cadherin_C","Cadherin cytoplasmic region. Cadherins are vital in cell-cell adhesion during tissue differentiation. Cadherins are linked to the cytoskeleton by catenins. Catenins bind to the cytoplasmic tail of the cadherin. Cadherins cluster to form foci of homophilic binding units. A key determinant to the strength of the binding that it is mediated by cadherins is the juxtamembrane region of the cadherin. This region induces clustering and also binds to the protein p120ctn.","GO:0001701|in utero embryonic development;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0050821|protein stabilization;GO:0098609|cell-cell adhesion;","GO:0005576|extracellular region;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0016021|integral component of membrane;GO:0030054|cell junction;GO:0030057|desmosome;","GO:0005509|calcium ion binding;GO:0045295|gamma-catenin binding;","K07602","DSC3; desmocollin 3"]
["ENSRNOG00000017821",83,5.339426369,38,2.453350667,2.176381241,1.121931299,{"v":3.77376e-05,"d":"3.77E-05"},{"v":2.72755E-5,"d":"2.73E-05"},"up","yes","Agxt2","protein_coding","chr2:59336283-59377926:+","gi|13929196|ref|NP_114023.1|",2781,0,"alanine--glyoxylate aminotransferase 2, mitochondrial [Rattus norvegicus]","gi|1944135|dbj|AB002584.1|",2146,0,"Rattus norvegicus mRNA for beta-alanine-pyruvate aminotransferase, complete cds","Q64565",1075,0,"Alanine--glyoxylate aminotransferase 2, mitochondrial","BMEII0348",301,{"v":6e-93,"d":"6.00E-93"},"COG0160","pfam00202","Aminotran_3","Aminotransferase class-III.","GO:0009436|glyoxylate catabolic process;GO:0019265|glycine biosynthetic process, by transamination of glyoxylate;GO:0019481|L-alanine catabolic process, by transamination;GO:0045429|positive regulation of nitric oxide biosynthetic process;","GO:0005739|mitochondrion;GO:0005759|mitochondrial matrix;","GO:0008453|alanine-glyoxylate transaminase activity;GO:0016223|beta-alanine-pyruvate transaminase activity;GO:0030170|pyridoxal phosphate binding;GO:0047305|(R)-3-amino-2-methylpropionate-pyruvate transaminase activity;","K00827","AGXT2; alanine-glyoxylate transaminase / (R)-3-amino-2-methylpropionate-pyruvate transaminase [EC:2.6.1.44 2.6.1.40]"]
["ENSRNOG00000059582",16,1.029287011,0,0.03228093,31.88529626,4.994819381,{"v":3.83485e-05,"d":"3.83E-05"},{"v":2.76995e-05,"d":"2.77E-05"},"up","yes","Odaph","protein_coding","chr14:16073058-16080129:-","gi|392333003|ref|XP_003752764.1|",307,{"v":3e-33,"d":"3.00E-33"},"PREDICTED: uncharacterized protein C4orf26 homolog [Rattus norvegicus]","gi|672027733|ref|XM_003752716.3|",387,0,"PREDICTED: Rattus norvegicus uncharacterized LOC100911949 (LOC100911949), mRNA","A0A0G2K6Z9",122,{"v":1e-34,"d":"1.00E-34"},"Odontogenesis-associated phosphoprotein",".",".",".",".","pfam00456","Transketolase_N","Transketolase, thiamine diphosphate binding domain. This family includes transketolase enzymes EC:2.2.1.1. and also partially matches to 2-oxoisovalerate dehydrogenase beta subunit EC:1.2.4.4. Both these enzymes utilize thiamine pyrophosphate as a cofactor, suggesting there may be common aspects in their mechanism of catalysis.","GO:0070169|positive regulation of biomineral tissue development;GO:0070175|positive regulation of enamel mineralization;","GO:0005576|extracellular region;",".","K24398","ODAPH; odontogenesis associated phosphoprotein"]
["ENSRNOG00000003025",60,3.859826291,23,1.484922772,2.599344803,1.37814802,{"v":3.83898e-05,"d":"3.84E-05"},{"v":2.77223e-05,"d":"2.77E-05"},"up","yes","AABR07039336.2","protein_coding","chrX:68173987-68176666:-","gi|67078440|ref|NP_001019960.1|",1987,0,"nucleosome assembly protein 1-like 2 [Rattus norvegicus]","gi|67078439|ref|NM_001024789.1|",2399,0,"Rattus norvegicus nucleosome assembly protein 1-like 2 (Nap1l2), mRNA","P51860",729,0,"Nucleosome assembly protein 1-like 2",".",".",".",".","pfam00956","NAP","Nucleosome assembly protein (NAP). NAP proteins are involved in moving histones into the nucleus, nucleosome assembly and chromatin fluidity. They affect the transcription of many genes.","GO:0035066|positive regulation of histone acetylation;GO:0045666|positive regulation of neuron differentiation;GO:0071442|positive regulation of histone H3-K14 acetylation;GO:2000035|regulation of stem cell division;GO:2000617|positive regulation of histone H3-K9 acetylation;",".","GO:0003682|chromatin binding;GO:0042393|histone binding;","K11280","NAP1L2, BPX; nucleosome assembly protein 1-like 2"]
["ENSRNOG00000020879",60,3.859826291,23,1.484922772,2.599344803,1.37814802,{"v":3.83898e-05,"d":"3.84E-05"},{"v":2.77223e-05,"d":"2.77E-05"},"up","yes","Nags","protein_coding","chr10:87098330-87102465:+","gi|564374250|ref|XP_006247390.1|",2409,0,"PREDICTED: N-acetylglutamate synthase, mitochondrial isoform X1 [Rattus norvegicus]","gi|157817439|ref|NM_001107053.1|",2111,0,"Rattus norvegicus N-acetylglutamate synthase (Nags), mRNA","Q8R4H7",883,0,"N-acetylglutamate synthase, mitochondrial","YER069w_1",122,{"v":2e-28,"d":"2.00E-28"},"COG0548","pfam04768","DUF619","Protein of unknown function (DUF619). This region of unknown function is found at the C-terminus of Neurospora crassa acetylglutamate synthase (amino-acid acetyltransferase, EC: 2.3.1.1). It is also found C-terminal to the amino acid kinase region (pfam00696) in some fungal acetylglutamate kinase enzymes.","GO:0006526|arginine biosynthetic process;GO:0006536|glutamate metabolic process;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005739|mitochondrion;GO:0005759|mitochondrial matrix;","GO:0004042|acetyl-CoA:L-glutamate N-acetyltransferase activity;GO:0034618|arginine binding;","K11067","NAGS; N-acetylglutamate synthase [EC:2.3.1.1]"]
["ENSRNOG00000050207",55,3.5381741,20,1.291237193,2.740142647,1.454250999,{"v":4.04552e-05,"d":"4.05E-05"},{"v":2.91549e-05,"d":"2.92E-05"},"up","yes","Utf1","protein_coding","chr1:194740339-194741465:+","gi|149061439|gb|EDM11862.1|",1400,0,"rCG47962 [Rattus norvegicus]","gi|196259784|ref|NM_001131032.1|",1011,0,"Rattus norvegicus undifferentiated embryonic cell transcription factor 1 (Utf1), mRNA","Q6J1H4",506,{"v":1e-178,"d":"1.00E-178"},"Undifferentiated embryonic cell transcription factor 1",".",".",".",".","pfam13837","Myb_DNA-bind_4","Myb/SANT-like DNA-binding domain. This presumed domain appears to be related to other Myb/SANT-like DNA binding domains. In particular pfam10545 seems most related. This family is greatly expanded in plants and appears in several proteins annotated as transposon proteins.","GO:0008584|male gonad development;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0003713|transcription coactivator activity;GO:0017025|TBP-class protein binding;GO:0071837|HMG box domain binding;",".","."]
["ENSRNOG00000047002",25,1.608260955,4,0.258247439,6.227596925,2.63867557,{"v":4.31835e-05,"d":"4.32E-05"},{"v":3.10232e-05,"d":"3.10E-05"},"up","yes","Fstl5","protein_coding","chr2:160856291-161526589:+","gi|403225027|ref|NP_001258124.1|",4560,0,"follistatin-related protein 5 precursor [Rattus norvegicus]","gi|403225026|ref|NM_001271195.1|",5084,0,"Rattus norvegicus follistatin-like 5 (Fstl5), mRNA","Q8BFR2",1718,0,"Follistatin-related protein 5",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0007275|multicellular organism development;GO:0030154|cell differentiation;","GO:0005576|extracellular region;","GO:0005509|calcium ion binding;","K23915","FSTL5; follistatin-related protein 5"]
["ENSRNOG00000002771",20,1.286608764,2,0.129123719,9.96415508,3.316747476,{"v":4.34624e-05,"d":"4.35E-05"},{"v":3.1213e-05,"d":"3.12E-05"},"up","yes","Ereg","protein_coding","chr14:17027287-17041062:-","gi|11078689|ref|NP_067721.1|",781,{"v":7e-102,"d":"7.00E-102"},"proepiregulin preproprotein [Rattus norvegicus]","gi|11078688|ref|NM_021689.1|",828,0,"Rattus norvegicus epiregulin (Ereg), mRNA","Q9Z0L5",305,{"v":2e-103,"d":"2.00E-103"},"Proepiregulin",".",".",".",".","pfam00008","EGF","EGF-like domain. There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.","GO:0001525|angiogenesis;GO:0001550|ovarian cumulus expansion;GO:0001556|oocyte maturation;GO:0001819|positive regulation of cytokine production;GO:0007143|female meiotic nuclear division;GO:0007173|epidermal growth factor receptor signaling pathway;GO:0007267|cell-cell signaling;GO:0008283|cell proliferation;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0009299|mRNA transcription;GO:0019221|cytokine-mediated signaling pathway;GO:0030728|ovulation;GO:0032755|positive regulation of interleukin-6 production;GO:0042327|positive regulation of phosphorylation;GO:0042700|luteinizing hormone signaling pathway;GO:0043434|response to peptide hormone;GO:0043616|keratinocyte proliferation;GO:0045089|positive regulation of innate immune response;GO:0045740|positive regulation of DNA replication;GO:0045741|positive regulation of epidermal growth factor-activated receptor activity;GO:0045766|positive regulation of angiogenesis;GO:0045840|positive regulation of mitotic nuclear division;GO:0045860|positive regulation of protein kinase activity;GO:0045892|negative regulation of transcription, DNA-templated;GO:0048146|positive regulation of fibroblast proliferation;GO:0048160|primary follicle stage;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0051151|negative regulation of smooth muscle cell differentiation;GO:0051781|positive regulation of cell division;","GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0005154|epidermal growth factor receptor binding;GO:0008083|growth factor activity;","K09784","EREG; epiregulin"]
["ENSRNOG00000022353",97,6.240052504,48,3.098969263,2.013589672,1.009769722,{"v":4.34641e-05,"d":"4.35E-05"},{"v":3.1213e-05,"d":"3.12E-05"},"up","yes","Klk13","protein_coding","chr1:94165381-94177002:+","gi|281427274|ref|NP_001163876.1|",1383,0,"kallikrein-13 precursor [Rattus norvegicus]","gi|281427273|ref|NM_001170405.1|",1038,0,"Rattus norvegicus kallikrein related-peptidase 13 (Klk13), mRNA","Q9UKR3",419,{"v":2e-145,"d":"2.00E-145"},"Kallikrein-13","mlr3307",85.9,{"v":3e-18,"d":"3.00E-18"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0016485|protein processing;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0030141|secretory granule;","GO:0004175|endopeptidase activity;GO:0004252|serine-type endopeptidase activity;GO:0016787|hydrolase activity;","K09463","KLK13; kallikrein 13 [EC:3.4.21.119]"]
["ENSRNOG00000069563",69,4.438800235,29,1.87229393,2.370781726,1.245362842,{"v":4.45666e-05,"d":"4.46E-05"},{"v":3.19766e-05,"d":"3.20E-05"},"up","yes","ENSRNOG00000069563","lncRNA","chr1:135772095-135773248:-",".",".",".",".","gi|354797786|gb|JN962287.1|",227,{"v":2E-113,"d":"2.00E-113"},"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Btbd1:tm1e(KOMP)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSRNOG00000021463",61,3.924156729,24,1.549484632,2.532556083,1.340594217,{"v":4.8161e-05,"d":"4.82E-05"},{"v":3.44387e-05,"d":"3.44E-05"},"up","yes","Ppara","protein_coding","chr7:116832756-116895346:+","gi|564361358|ref|XP_006242213.1|",2383,0,"PREDICTED: peroxisome proliferator-activated receptor alpha isoform X2 [Rattus norvegicus]","gi|6981381|ref|NM_013196.1|",2017,0,"Rattus norvegicus peroxisome proliferator activated receptor alpha (Ppara), mRNA","P37230",885,0,"Peroxisome proliferator-activated receptor alpha",".",".",".",".","pfam00105","zf-C4","Zinc finger, C4 type (two domains). In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001666|response to hypoxia;GO:0006355|regulation of transcription, DNA-templated;GO:0006631|fatty acid metabolic process;GO:0007507|heart development;GO:0008544|epidermis development;GO:0009267|cellular response to starvation;GO:0009755|hormone-mediated signaling pathway;GO:0010468|regulation of gene expression;GO:0010565|regulation of cellular ketone metabolic process;GO:0010745|negative regulation of macrophage derived foam cell differentiation;GO:0010876|lipid localization;GO:0010883|regulation of lipid storage;GO:0010887|negative regulation of cholesterol storage;GO:0010891|negative regulation of sequestering of triglyceride;GO:0014070|response to organic cyclic compound;GO:0019216|regulation of lipid metabolic process;GO:0019217|regulation of fatty acid metabolic process;GO:0030154|cell differentiation;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030522|intracellular receptor signaling pathway;GO:0032091|negative regulation of protein binding;GO:0032099|negative regulation of appetite;GO:0032868|response to insulin;GO:0032922|circadian regulation of gene expression;GO:0033993|response to lipid;GO:0035095|behavioral response to nicotine;GO:0042060|wound healing;GO:0042157|lipoprotein metabolic process;GO:0042752|regulation of circadian rhythm;GO:0043401|steroid hormone mediated signaling pathway;GO:0045070|positive regulation of viral genome replication;GO:0045471|response to ethanol;GO:0045722|positive regulation of gluconeogenesis;GO:0045776|negative regulation of blood pressure;GO:0045820|negative regulation of glycolytic process;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045923|positive regulation of fatty acid metabolic process;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046321|positive regulation of fatty acid oxidation;GO:0046889|positive regulation of lipid biosynthetic process;GO:0050728|negative regulation of inflammatory response;GO:0051898|negative regulation of protein kinase B signaling;GO:0061052|negative regulation of cell growth involved in cardiac muscle cell development;GO:0070166|enamel mineralization;GO:1900016|negative regulation of cytokine production involved in inflammatory response;GO:1901215|negative regulation of neuron death;GO:1902894|negative regulation of pri-miRNA transcription by RNA polymerase II;GO:1903038|negative regulation of leukocyte cell-cell adhesion;GO:1903427|negative regulation of reactive oxygen species biosynthetic process;GO:1903944|negative regulation of hepatocyte apoptotic process;GO:2000272|negative regulation of signaling receptor activity;GO:2001171|positive regulation of ATP biosynthetic process;","GO:0005634|nucleus;GO:0005654|nucleoplasm;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001223|transcription coactivator binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0003707|steroid hormone receptor activity;GO:0004879|nuclear receptor activity;GO:0005515|protein binding;GO:0008270|zinc ion binding;GO:0008289|lipid binding;GO:0019902|phosphatase binding;GO:0019904|protein domain specific binding;GO:0031624|ubiquitin conjugating enzyme binding;GO:0038023|signaling receptor activity;GO:0043565|sequence-specific DNA binding;GO:0044877|protein-containing complex binding;GO:0051525|NFAT protein binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;GO:0097371|MDM2/MDM4 family protein binding;","K07294","NR1C1, PPARA; peroxisome proliferator-activated receptor alpha"]
["ENSRNOG00000064667",17,1.093617449,1,0.06456186,16.93906364,4.082282222,{"v":4.84862e-05,"d":"4.85E-05"},{"v":3.46627e-05,"d":"3.47E-05"},"up","yes","Tmem86b","pseudogene","chr1:69218608-69220124:+","gi|564326271|ref|XP_006228351.1|",882,{"v":5E-117,"d":"5.00E-117"},"PREDICTED: lysoplasmalogenase isoform X1 [Rattus norvegicus]","gi|672035218|ref|XM_006228289.2|",591,0,"PREDICTED: Rattus norvegicus transmembrane protein 86B (Tmem86b), transcript variant X1, mRNA","B0BNF0",344,{"v":2E-118,"d":"2.00E-118"},"Lysoplasmalogenase",".",".",".",".","pfam07947","YhhN","YhhN-like protein. The members of this family are similar to the hypothetical protein yhhN expressed by Escherichia coli. Many of the members of this family are annotated as being possible transmembrane proteins, and in fact they all have a high proportion of hydrophobic residues.",".",".",".",".","."]
["ENSRNOG00000020242",39,2.508887089,11,0.710180456,3.532745892,1.820789981,{"v":4.87607e-05,"d":"4.88E-05"},{"v":3.48458e-05,"d":"3.48E-05"},"up","yes","Art5","protein_coding","chr1:156473362-156483324:-","gi|564330007|ref|XP_006229905.1|",1639,0,"PREDICTED: ecto-ADP-ribosyltransferase 5 isoform X1 [Rattus norvegicus]","gi|61556766|ref|NM_001013039.1|",1981,0,"Rattus norvegicus ADP-ribosyltransferase 5 (Art5), mRNA","Q5XHY4",629,0,"Ecto-ADP-ribosyltransferase 5",".",".",".",".","pfam01129","ART","NAD:arginine ADP-ribosyltransferase.","GO:0006471|protein ADP-ribosylation;GO:0018120|peptidyl-arginine ADP-ribosylation;","GO:0005576|extracellular region;GO:0016020|membrane;","GO:0003950|NAD+ ADP-ribosyltransferase activity;GO:0003953|NAD+ nucleosidase activity;","K19977","ART5; ADP-ribosyltransferase 5 [EC:2.4.2.31]"]
["ENSRNOG00000064312",39,2.508887089,11,0.710180456,3.532745892,1.820789981,{"v":4.87607e-05,"d":"4.88E-05"},{"v":3.48458e-05,"d":"3.48E-05"},"up","yes","ENSRNOG00000064312","lncRNA","chr8:118235396-118241659:+","gi|300797432|ref|NP_001178009.1|",286,{"v":3e-46,"d":"3.00E-46"},"golgin subfamily A member 4 [Rattus norvegicus]","gi|672063646|ref|XM_006244133.2|",380,0,"PREDICTED: Rattus norvegicus golgin A4 (Golga4), transcript variant X8, mRNA","Q5U4E6",114,{"v":3e-47,"d":"3.00E-47"},"Golgin subfamily A member 4",".",".",".",".","pfam15070","GOLGA2L5","Putative golgin subfamily A member 2-like protein 5. The function of the GOLGA2L5 protein family remains unknown. This family of proteins is thought to be found in the Golgi apparatus of eukaryotes. Proteins in this family are typically between and 840 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000060988",27,1.736921831,5,0.322809298,5.380643743,2.427778788,{"v":4.99091E-5,"d":"4.99E-05"},{"v":3.56219e-05,"d":"3.56E-05"},"up","yes","Kcnc4","protein_coding","chr2:195071769-195099233:-","gi|533149300|ref|XP_005388971.1|",2600,0,"PREDICTED: potassium voltage-gated channel subfamily C member 4 isoform X1 [Chinchilla lanigera]","gi|755504914|ref|XM_006502475.2|",5152,0,"PREDICTED: Mus musculus potassium voltage gated channel, Shaw-related subfamily, member 4 (Kcnc4), transcript variant X1, mRNA","Q63734",919,0,"Potassium voltage-gated channel subfamily C member 4","DR0830",59.7,3e-08,"COG1226","pfam02214","BTB_2","BTB/POZ domain. In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.","GO:0030900|forebrain development;GO:0034765|regulation of ion transmembrane transport;GO:0046928|regulation of neurotransmitter secretion;GO:0051260|protein homooligomerization;GO:0060078|regulation of postsynaptic membrane potential;GO:0071805|potassium ion transmembrane transport;GO:0099505|regulation of presynaptic membrane potential;GO:1904057|negative regulation of sensory perception of pain;GO:1904456|negative regulation of neuronal action potential;","GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0008021|synaptic vesicle;GO:0008076|voltage-gated potassium channel complex;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0031594|neuromuscular junction;GO:0032590|dendrite membrane;GO:0032809|neuronal cell body membrane;GO:0043025|neuronal cell body;GO:0043679|axon terminus;GO:0044305|calyx of Held;GO:0098690|glycinergic synapse;GO:0098794|postsynapse;GO:0098978|glutamatergic synapse;GO:0099055|integral component of postsynaptic membrane;GO:0099056|integral component of presynaptic membrane;","GO:0005249|voltage-gated potassium channel activity;GO:0005251|delayed rectifier potassium channel activity;GO:0005515|protein binding;GO:0099508|voltage-gated ion channel activity involved in regulation of presynaptic membrane potential;GO:1905030|voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K04890","KCNC4, KV3.4; potassium voltage-gated channel Shaw-related subfamily C member 4"]
["ENSRNOG00000060054",64,4.117148044,26,1.678608351,2.452715097,1.294379663,{"v":5.0798e-05,"d":"5.08E-05"},{"v":3.62337e-05,"d":"3.62E-05"},"up","yes","Doc2b","protein_coding","chr10:60628029-60653267:-","gi|13592129|ref|NP_112404.1|",1664,0,"double C2-like domain-containing protein beta [Rattus norvegicus]","gi|13592128|ref|NM_031142.1|",1067,0,"Rattus norvegicus double C2-like domains, beta (Doc2b), mRNA","P70610",645,0,"Double C2-like domain-containing protein beta","YNL087w",57.8,8e-08,"COG5038","pfam00168","C2","C2 domain.","GO:0006886|intracellular protein transport;GO:0006887|exocytosis;GO:0008104|protein localization;GO:0031340|positive regulation of vesicle fusion;GO:0032024|positive regulation of insulin secretion;GO:0045956|positive regulation of calcium ion-dependent exocytosis;GO:0048791|calcium ion-regulated exocytosis of neurotransmitter;GO:0061669|spontaneous neurotransmitter secretion;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0045202|synapse;GO:0098793|presynapse;","GO:0005509|calcium ion binding;GO:0005544|calcium-dependent phospholipid binding;GO:0019905|syntaxin binding;","K19917","DOC2B; double C2-like domain-containing protein beta"]
["ENSRNOG00000016110",95,6.111391628,47,3.034407404,2.014031346,1.010086137,{"v":5.18941e-05,"d":"5.19E-05"},{"v":3.69832e-05,"d":"3.70E-05"},"up","yes","Kcnk12","protein_coding","chr6:6739991-6790661:+","gi|562868708|ref|XP_006162413.1|",1538,0,"PREDICTED: potassium channel subfamily K member 12 [Tupaia chinensis]","gi|67972619|gb|AC124316.32|",1553,0,"Mus musculus chromosome 17, clone RP24-222O13, complete sequence","Q9ERS1",555,0,"Potassium channel subfamily K member 12",".",".",".",".","pfam07885","Ion_trans_2","Ion channel. This family includes the two membrane helix type ion channels found in bacteria.","GO:0030322|stabilization of membrane potential;GO:0034765|regulation of ion transmembrane transport;GO:0071805|potassium ion transmembrane transport;","GO:0005887|integral component of plasma membrane;","GO:0005244|voltage-gated ion channel activity;GO:0022841|potassium ion leak channel activity;","K04921","KCNK12, K2P12.1; potassium channel subfamily K member 12"]
["ENSRNOG00000015675",56,3.602504538,21,1.355799053,2.657108021,1.40985688,{"v":5.19713e-05,"d":"5.20E-05"},{"v":3.70244e-05,"d":"3.70E-05"},"up","yes","Nell1","protein_coding","chr1:99709793-100573860:+","gi|149055782|gb|EDM07213.1|",4231,0,"NEL-like 1 (chicken), isoform CRA_a [Rattus norvegicus]","gi|13592010|ref|NM_031069.1|",2869,0,"Rattus norvegicus neural EGFL like 1 (Nell1), mRNA","Q62919",1624,0,"Protein kinase C-binding protein NELL1",".",".",".",".","pfam00093","VWC","von Willebrand factor type C domain. The high cutoff was used to prevent overlap with pfam00094.","GO:0010468|regulation of gene expression;GO:0030154|cell differentiation;GO:0030501|positive regulation of bone mineralization;GO:0033689|negative regulation of osteoblast proliferation;GO:0043065|positive regulation of apoptotic process;GO:0045667|regulation of osteoblast differentiation;GO:0045669|positive regulation of osteoblast differentiation;GO:0045778|positive regulation of ossification;GO:1903363|negative regulation of cellular protein catabolic process;","GO:0005615|extracellular space;GO:0005635|nuclear envelope;GO:0005737|cytoplasm;GO:0048471|perinuclear region of cytoplasm;","GO:0005080|protein kinase C binding;GO:0005509|calcium ion binding;GO:0008201|heparin binding;GO:0042802|identical protein binding;","K24342","NELL; protein kinase C-binding protein NELL"]
["ENSRNOG00000046181",37,2.380226213,10,0.645618597,3.68673738,1.882344651,{"v":5.20282e-05,"d":"5.20E-05"},{"v":3.70556e-05,"d":"3.71E-05"},"up","yes","Anks4b","protein_coding","chr1:174547473-174557797:+","gi|189083739|ref|NP_001121122.1|",1973,0,"ankyrin repeat and SAM domain-containing protein 4B [Rattus norvegicus]","gi|189083738|ref|NM_001127650.1|",1993,0,"Rattus norvegicus ankyrin repeat and sterile alpha motif domain containing 4B (Anks4b), mRNA","Q8K3X6",699,0,"Ankyrin repeat and SAM domain-containing protein 4B","FN0178",60.8,4e-09,"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0034622|cellular protein-containing complex assembly;GO:0034976|response to endoplasmic reticulum stress;GO:1904106|protein localization to microvillus;GO:1904970|brush border assembly;","GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0005902|microvillus;GO:0005903|brush border;",".","K21414","ANKS4B, HARP; ankyrin repeat and SAM domain-containing protein 4B"]
["ENSRNOG00000000840",67,4.310139358,28,1.80773207,2.384279966,1.253553649,{"v":5.26485e-05,"d":"5.26E-05"},{"v":3.7474e-05,"d":"3.75E-05"},"up","yes","Atp6v1g2","protein_coding","chr20:3587686-3590481:-","gi|47059104|ref|NP_997655.1|",303,{"v":3e-29,"d":"3.00E-29"},"V-type proton ATPase subunit G 2 [Rattus norvegicus]","gi|110350025|gb|AC130591.5|",1660,0,"Rattus norvegicus BAC CH230-312A21 () complete sequence","Q5WR09",117,{"v":2e-29,"d":"2.00E-29"},"V-type proton ATPase subunit G 1",".",".",".",".","pfam03179","V-ATPase_G","Vacuolar (H+)-ATPase G subunit. This family represents the eukaryotic vacuolar (H+)-ATPase (V-ATPase) G subunit. V-ATPases generate an acidic environment in several intracellular compartments. Correspondingly, they are found as membrane-attached proteins in several organelles. They are also found in the plasma membranes of some specialized cells. V-ATPases consist of peripheral (V1) and membrane integral (V0) heteromultimeric complexes. The G subunit is part of the V1 subunit, but is also thought to be strongly attached to the V0 complex. It may be involved in the coupling of ATP degradation to H+ translocation.","GO:1902600|proton transmembrane transport;","GO:0016471|vacuolar proton-transporting V-type ATPase complex;GO:0030285|integral component of synaptic vesicle membrane;","GO:0008553|proton-exporting ATPase activity, phosphorylative mechanism;GO:0016887|ATPase activity;GO:0046961|proton-transporting ATPase activity, rotational mechanism;","K02152","ATPeV1G, ATP6G; V-type H+-transporting ATPase subunit G"]
["ENSRNOG00000012620",51,3.280852347,18,1.162113474,2.823177273,1.497319721,{"v":5.35465E-5,"d":"5.35E-05"},{"v":3.80942e-05,"d":"3.81E-05"},"up","yes","Syngr3","protein_coding","chr10:13704998-13715669:-","gi|831227424|ref|XP_003790837.2|",961,{"v":1e-120,"d":"1.00E-120"},"PREDICTED: synaptogyrin-3 [Otolemur garnettii]","gi|672066853|ref|XM_006245947.2|",1993,0,"PREDICTED: Rattus norvegicus synaptogyrin 3 (Syngr3), transcript variant X1, mRNA","Q8R191",367,{"v":1E-119,"d":"1.00E-119"},"Synaptogyrin-3",".",".",".",".","pfam01284","MARVEL","Membrane-associating domain. MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.","GO:0001504|neurotransmitter uptake;GO:0021762|substantia nigra development;GO:0032411|positive regulation of transporter activity;GO:0045055|regulated exocytosis;","GO:0008021|synaptic vesicle;GO:0016021|integral component of membrane;GO:0030672|synaptic vesicle membrane;GO:0031594|neuromuscular junction;GO:0045202|synapse;","GO:0042169|SH2 domain binding;GO:0047485|protein N-terminus binding;",".","."]
["ENSRNOG00000047682",29,1.865582707,6,0.387371158,4.816008289,2.267837875,{"v":5.41357e-05,"d":"5.41E-05"},{"v":3.84895e-05,"d":"3.85E-05"},"up","yes","AABR07065031.1","protein_coding","chr6:101256172-101265662:-","gi|672020940|ref|XP_008774512.1|",3897,0,"PREDICTED: disintegrin and metalloproteinase domain-containing protein 21 [Rattus norvegicus]","gi|672056892|ref|XM_008764883.1|",2623,0,"PREDICTED: Rattus norvegicus disintegrin and metalloproteinase domain-containing protein 21-like (LOC103690152), mRNA","Q9JI76",1303,0,"Disintegrin and metalloproteinase domain-containing protein 21",".",".",".",".","pfam01421","Reprolysin","Reprolysin (M12B) family zinc metalloprotease. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as human ADAM8 and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.",".",".",".",".","."]
["ENSRNOG00000061731",29,1.865582707,6,0.387371158,4.816008289,2.267837875,{"v":5.41357e-05,"d":"5.41E-05"},{"v":3.84895e-05,"d":"3.85E-05"},"up","yes","Plxnb3","protein_coding","chrX:151494207-151508674:+","gi|209529650|ref|NP_001129350.1|",9274,0,"plexin-B3 precursor [Rattus norvegicus]","gi|672088967|ref|XM_006229587.2|",6100,0,"PREDICTED: Rattus norvegicus plexin B3 (Plxnb3), transcript variant X3, mRNA","D3ZLH5",3573,0,"Plexin-B3",".",".",".",".","pfam08337","Plexin_cytopl","Plexin cytoplasmic RasGAP domain. This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.","GO:0001938|positive regulation of endothelial cell proliferation;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007162|negative regulation of cell adhesion;GO:0008360|regulation of cell shape;GO:0010593|negative regulation of lamellipodium assembly;GO:0010976|positive regulation of neuron projection development;GO:0030334|regulation of cell migration;GO:0030336|negative regulation of cell migration;GO:0034260|negative regulation of GTPase activity;GO:0043087|regulation of GTPase activity;GO:0050772|positive regulation of axonogenesis;GO:0050918|positive chemotaxis;GO:0060326|cell chemotaxis;GO:0071526|semaphorin-plexin signaling pathway;GO:1902287|semaphorin-plexin signaling pathway involved in axon guidance;","GO:0002116|semaphorin receptor complex;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;","GO:0017154|semaphorin receptor activity;GO:0019904|protein domain specific binding;GO:0051022|Rho GDP-dissociation inhibitor binding;GO:0098632|cell-cell adhesion mediator activity;","K06821","PLXNB; plexin B"]
["ENSRNOG00000010337",31,1.994243584,7,0.451933018,4.41269725,2.141660769,{"v":5.60602e-05,"d":"5.61E-05"},{"v":3.97964e-05,"d":"3.98E-05"},"up","yes","Slc13a2","protein_coding","chr10:63291815-63319127:-","gi|13929048|ref|NP_113934.1|",2731,0,"solute carrier family 13 member 2 [Rattus norvegicus]","gi|13929047|ref|NM_031746.1|",2425,0,"Rattus norvegicus solute carrier family 13 member 2 (Slc13a2), mRNA","P70545",1019,0,"Solute carrier family 13 member 2","SA1732",261,{"v":3e-76,"d":"3.00E-76"},"COG0471","pfam00939","Na_sulph_symp","Sodium:sulfate symporter transmembrane region. There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.","GO:0006814|sodium ion transport;GO:0055085|transmembrane transport;GO:0071422|succinate transmembrane transport;GO:0098656|anion transmembrane transport;","GO:0016021|integral component of membrane;","GO:0015141|succinate transmembrane transporter activity;GO:0015293|symporter activity;GO:0022857|transmembrane transporter activity;","K14445","SLC13A2_3_5; solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2/3/5"]
["ENSRNOG00000063177",33,2.12290446,8,0.516494877,4.11021397,2.0392135,{"v":5.60645e-05,"d":"5.61E-05"},{"v":3.97964e-05,"d":"3.98E-05"},"up","yes","ENSRNOG00000063177","lncRNA","chr19:22369252-22370454:+","gi|149026742|gb|EDL82735.1|",239,{"v":6e-22,"d":"6.00E-22"},"rCG51697 [Rattus norvegicus]","gi|672084642|ref|XR_361784.2|",636,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102550991 (LOC102550991), ncRNA",".",".",".",".",".",".",".",".","pfam12292","DUF3624","Protein of unknown function (DUF3624). This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length. There is a conserved GRC sequence motif.",".",".",".",".","."]
["ENSRNOG00000056825",59,3.795495853,23,1.484922772,2.55602239,1.353900474,{"v":5.63564e-05,"d":"5.64E-05"},{"v":3.99986E-5,"d":"4.00E-05"},"up","yes","AABR07072539.4","lncRNA","chr6:123970709-123978469:-","gi|564379463|ref|XP_006249439.1|",728,{"v":3e-125,"d":"3.00E-125"},"PREDICTED: 60S ribosomal protein L6 isoform X2 [Rattus norvegicus]","gi|672021090|ref|XR_601595.1|",568,0,"PREDICTED: Rattus norvegicus ribosomal protein L6, pseudogene 1 (Rpl6-ps1), misc_RNA","P21533",283,{"v":3e-126,"d":"3.00E-126"},"60S ribosomal protein L6","SPCC622.18",72,{"v":1E-22,"d":"1.00E-22"},"COG2163","pfam01159","Ribosomal_L6e","Ribosomal protein L6e.",".",".",".",".","."]
["ENSRNOG00000065542",22,1.41526964,3,0.193685579,7.307047059,2.869288499,{"v":6.11313e-05,"d":"6.11E-05"},{"v":4.32908e-05,"d":"4.33E-05"},"up","yes","ENSRNOG00000065542","lncRNA","chr6:26151158-26153468:-",".",".",".",".","gi|308818313|gb|AC241618.4|",573,0,"Mus musculus BAC clone CH25-471I10 from chromosome 5, complete sequence",".",".",".",".",".",".",".",".","pfam12217","End_beta_propel","Catalytic beta propeller domain of bacteriophage endosialidase. This domain family is found in bacteria and viruses, and is typically between 443 and 460 amino acids in length. This domain is the highly conserved beta propeller of bacteriophage endosialidase which represents the catalytically active part of the enzymes. This core domain forms stable SDS-resistant trimers. There is a nested beta barrel domain in this domain (pfam12195). The endosialidase protein complexes to form a homotrimeric molecule.",".",".",".",".","."]
["ENSRNOG00000042751",52,3.345182786,19,1.226675333,2.727031917,1.447331585,{"v":6.97554E-5,"d":"6.98E-05"},{"v":4.91057E-5,"d":"4.91E-05"},"up","yes","ENSRNOG00000042751","protein_coding","chrX:50966208-50967245:-","gi|157819847|ref|NP_001102837.1|",1673,0,"melanoma antigen, family B, 7 [Rattus norvegicus]","gi|672087665|ref|XM_006256984.2|",1038,0,"PREDICTED: Rattus norvegicus melanoma antigen, family B, 7 (Mageb7), transcript variant X1, mRNA","A2A9R3",304,{"v":1e-96,"d":"1.00E-96"},"Melanoma-associated antigen B4",".",".",".",".","pfam01454","MAGE","MAGE family. The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumors but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.",".",".",".","K24127","MAGE; melanoma-associated antigen"]
["ENSRNOG00000022848",47,3.023530595,16,1.032989754,2.926970555,1.549408232,{"v":6.98549e-05,"d":"6.99E-05"},{"v":4.91697e-05,"d":"4.92E-05"},"up","yes","ENSRNOG00000022848","protein_coding","chrX:56659405-56734641:-","gi|67846038|ref|NP_001020051.1|",1820,0,"uncharacterized protein LOC302434 [Rattus norvegicus]","gi|672087627|ref|XM_006257009.2|",1442,0,"PREDICTED: Rattus norvegicus similar to MAGEB3 (MGC114483), transcript variant X1, mRNA","O15481",267,{"v":6e-83,"d":"6.00E-83"},"Melanoma-associated antigen B4",".",".",".",".","pfam01454","MAGE","MAGE family. The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumors but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.","GO:0000122|negative regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;",".","K24127","MAGE; melanoma-associated antigen"]
["ENSRNOG00000007232",15,0.964956573,0,0.03228093,29.89246524,4.901709976,{"v":7.01451e-05,"d":"7.01E-05"},{"v":4.93496e-05,"d":"4.93E-05"},"up","yes","Lao1","protein_coding","chr5:132573698-132583582:+","gi|157817668|ref|NP_001100152.1|",2519,0,"L-amino acid oxidase 1 precursor [Rattus norvegicus]","gi|157817667|ref|NM_001106682.1|",1887,0,"Rattus norvegicus L-amino acid oxidase 1 (Lao1), mRNA","A8QL52",464,{"v":3e-155,"d":"3.00E-155"},"L-amino-acid oxidase","BS_yobN",218,{"v":2e-62,"d":"2.00E-62"},"COG1231","pfam01593","Amino_oxidase","Flavin containing amine oxidoreductase. This family consists of various amine oxidases, including maze polyamine oxidase (PAO) and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.","GO:0009063|cellular amino acid catabolic process;","GO:0005576|extracellular region;","GO:0001716|L-amino-acid oxidase activity;GO:0016491|oxidoreductase activity;GO:0046592|polyamine oxidase activity;","K03334","IL4I1; L-amino-acid oxidase [EC:1.4.3.2]"]
["ENSRNOG00000010459",15,0.964956573,0,0.03228093,29.89246524,4.901709976,{"v":7.01451e-05,"d":"7.01E-05"},{"v":4.93496e-05,"d":"4.93E-05"},"up","yes","Fbxo43","protein_coding","chr7:67333162-67346751:-","gi|209915571|ref|NP_001012117.2|",3170,0,"F-box only protein 43 [Rattus norvegicus]","gi|58865803|ref|NM_001012117.1|",2525,0,"Rattus norvegicus F-box protein 43 (Fbxo43), mRNA","Q66H04",1223,0,"F-box only protein 43",".",".",".",".","pfam01485","IBR","IBR domain. The IBR (In Between Ring fingers) domain is often found to occur between pairs of ring fingers (pfam00097). This domain has also been called the C6HC domain and DRIL (for double RING finger linked) domain. Proteins that contain two Ring fingers and an IBR domain (these proteins are also termed RBR family proteins) are thought to exist in all eukaryotic organisms. RBR family members play roles in protein quality control and can indirectly regulate transcription. Evidence suggests that RBR proteins are often parts of cullin-containing ubiquitin ligase complexes. The ubiquitin ligase Parkin is an RBR family protein whose mutations are involved in forms of familial Parkinson's disease.","GO:0007088|regulation of mitotic nuclear division;GO:0016567|protein ubiquitination;GO:0040020|regulation of meiotic nuclear division;GO:0042177|negative regulation of protein catabolic process;GO:0045835|negative regulation of meiotic nuclear division;GO:0051321|meiotic cell cycle;","GO:0005634|nucleus;","GO:0046872|metal ion binding;","K10318","FBXO43, EMI2; F-box protein 43"]
["ENSRNOG00000004440",60,3.859826291,24,1.549484632,2.49103877,1.316747476,{"v":7.01972e-05,"d":"7.02E-05"},{"v":4.93742e-05,"d":"4.94E-05"},"up","yes","Fignl1","protein_coding","chr14:86368675-86377455:-","gi|58865396|ref|NP_001011913.1|",3643,0,"fidgetin-like protein 1 [Rattus norvegicus]","gi|672076617|ref|XM_006251477.2|",2843,0,"PREDICTED: Rattus norvegicus fidgetin-like 1 (Fignl1), transcript variant X3, mRNA","Q6GX84",1407,0,"Fidgetin-like protein 1","ECU11g1030",384,{"v":2e-122,"d":"2.00E-122"},"COG0464","pfam00004","AAA","ATPase family associated with various cellular activities (AAA). AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.","GO:0001649|osteoblast differentiation;GO:0007140|male meiotic nuclear division;GO:0010569|regulation of double-strand break repair via homologous recombination;GO:0033687|osteoblast proliferation;GO:0043066|negative regulation of apoptotic process;GO:0046034|ATP metabolic process;GO:0051013|microtubule severing;GO:0051726|regulation of cell cycle;GO:0071479|cellular response to ionizing radiation;GO:2001243|negative regulation of intrinsic apoptotic signaling pathway;","GO:0000228|nuclear chromosome;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0048471|perinuclear region of cytoplasm;","GO:0000287|magnesium ion binding;GO:0005524|ATP binding;GO:0008568|microtubule-severing ATPase activity;GO:0016787|hydrolase activity;","K22766","FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]"]
["ENSRNOG00000010658",60,3.859826291,24,1.549484632,2.49103877,1.316747476,{"v":7.01972e-05,"d":"7.02E-05"},{"v":4.93742e-05,"d":"4.94E-05"},"up","yes","Cth","protein_coding","chr2:246975894-247002234:-","gi|672044593|ref|XP_008759796.1|",2074,0,"PREDICTED: cystathionine gamma-lyase [Rattus norvegicus]","gi|51261010|gb|BC078869.1|",1769,0,"Rattus norvegicus cystathionase (cystathionine gamma-lyase), mRNA (cDNA clone MGC:93537 IMAGE:7109746), complete cds","P18757",795,0,"Cystathionine gamma-lyase","APE1226",407,{"v":7e-136,"d":"7.00E-136"},"COG0626","pfam01053","Cys_Met_Meta_PP","Cys/Met metabolizm PLP-dependent enzyme. This family includes enzymes involved in cysteine and methionine metabolizm. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.","GO:0006749|glutathione metabolic process;GO:0008285|negative regulation of cell proliferation;GO:0018272|protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine;GO:0019343|cysteine biosynthetic process via cystathionine;GO:0019344|cysteine biosynthetic process;GO:0019346|transsulfuration;GO:0030308|negative regulation of cell growth;GO:0043066|negative regulation of apoptotic process;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0044524|protein sulfhydration;GO:0050667|homocysteine metabolic process;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051289|protein homotetramerization;GO:0070814|hydrogen sulfide biosynthetic process;GO:1904831|positive regulation of aortic smooth muscle cell differentiation;GO:1990830|cellular response to leukemia inhibitory factor;GO:2001234|negative regulation of apoptotic signaling pathway;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004121|cystathionine beta-lyase activity;GO:0004123|cystathionine gamma-lyase activity;GO:0005516|calmodulin binding;GO:0016846|carbon-sulfur lyase activity;GO:0030170|pyridoxal phosphate binding;GO:0042802|identical protein binding;GO:0044540|L-cystine L-cysteine-lyase (deaminating);GO:0080146|L-cysteine desulfhydrase activity;","K01758","CTH; cystathionine gamma-lyase [EC:4.4.1.1]"]
["ENSRNOG00000064088",24,1.543930516,4,0.258247439,5.978493048,2.579781881,{"v":7.56205e-05,"d":"7.56E-05"},{"v":5.30124e-05,"d":"5.30E-05"},"up","yes","ENSRNOG00000064088","protein_coding","chr9:106027363-106052080:-","gi|672033317|ref|XP_008756392.1|",2641,0,"PREDICTED: sperm motility kinase W-like [Rattus norvegicus]","gi|672033318|ref|XM_008758171.1|",5117,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102555328 (LOC102555328), transcript variant X2, mRNA","Q8C0V7",559,{"v":1E-175,"d":"1.00E-175"},"Putative sperm motility kinase W",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.",".",".",".",".","."]
["ENSRNOG00000069245",24,1.543930516,4,0.258247439,5.978493048,2.579781881,{"v":7.56205e-05,"d":"7.56E-05"},{"v":5.30124e-05,"d":"5.30E-05"},"up","yes","ENSRNOG00000069245","protein_coding","chr17:41570273-41571049:-","gi|537211922|gb|ERE80724.1|",551,{"v":1e-67,"d":"1.00E-67"},"histone H2A type 1-F-like protein [Cricetulus griseus]","gi|56345|emb|X59961.1|",706,0,"R.norvegicus genes for H2A and H2B histones","Q8CGP5",215,{"v":9e-69,"d":"9.00E-69"},"Histone H2A type 1-F","SPCC622.08c",179,{"v":2E-55,"d":"2.00E-55"},"COG5262","pfam00125","Histone","Core histone H2A/H2B/H3/H4.",".",".",".",".","."]
["ENSRNOG00000061237",26,1.672591393,5,0.322809298,5.181360642,2.373331004,{"v":8.57079e-05,"d":"8.57E-05"},{"v":5.97758e-05,"d":"5.98E-05"},"up","yes","Dio1","protein_coding","chr5:122074279-122090970:-","gi|2654263|emb|CAA41063.1|",1305,{"v":2e-173,"d":"2.00E-173"},"thyroxine deiodinase [Rattus norvegicus]","gi|57330|emb|X57999.1|",2051,0,"Rattus norvegicus mRNA for type I thyroxine deiodinase","P24389",507,{"v":5E-175,"d":"5.00E-175"},"Type I iodothyronine deiodinase",".",".",".",".","pfam00837","T4_deiodinase","Iodothyronine deiodinase. Iodothyronine deiodinase converts thyroxine (T4) to 3,5,3'-triiodothyronine (T3).","GO:0006091|generation of precursor metabolites and energy;GO:0006520|cellular amino acid metabolic process;GO:0042403|thyroid hormone metabolic process;GO:0042446|hormone biosynthetic process;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0004800|thyroxine 5'-deiodinase activity;GO:0008430|selenium binding;","K01562","DIO1; type I thyroxine 5'-deiodinase [EC:1.21.99.4]"]
["ENSRNOG00000067267",61,3.924156729,25,1.614046491,2.431253839,1.281700528,{"v":8.64835E-5,"d":"8.65E-05"},{"v":6.02726e-05,"d":"6.03E-05"},"up","yes","ENSRNOG00000067267","lncRNA","chr14:97284302-97285408:+",".",".",".",".","gi|27764053|emb|AL772359.8|",370,0,"Mouse DNA sequence from clone RP23-305E10 on chromosome 11, complete sequence",".",".",".",".",".",".",".",".","pfam15223","DUF4584","Domain of unknown function (DUF4584). This family of proteins is found in eukaryotes. Proteins in this family are approximately 835 amino acids in length. The family is found in association with pfam02437.",".",".",".",".","."]
["ENSRNOG00000067280",34,2.187234898,9,0.581056737,3.764236363,1.91235722,{"v":8.84682e-05,"d":"8.85E-05"},{"v":6.16107e-05,"d":"6.16E-05"},"up","yes","ENSRNOG00000067280","protein_coding","chr9:12941405-12943070:+","gi|392342242|ref|XP_003754540.1|",966,{"v":1e-128,"d":"1.00E-128"},"PREDICTED: histone H3.v1-like isoform X2 [Rattus norvegicus]","gi|672064478|ref|XM_003750642.3|",802,0,"PREDICTED: Rattus norvegicus uncharacterized LOC100911489 (LOC100911489), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.",".",".",".",".","."]
["ENSRNOG00000020907",43,2.766208842,14,0.903866035,3.06041906,1.613729213,{"v":8.93652e-05,"d":"8.94E-05"},{"v":6.2205e-05,"d":"6.22E-05"},"up","yes","Zp1","protein_coding","chr1:207560881-207567261:-","gi|149062430|gb|EDM12853.1|",2998,0,"rCG47565 [Rattus norvegicus]","gi|16758239|ref|NM_053509.1|",1944,0,"Rattus norvegicus zona pellucida glycoprotein 1 (Zp1), mRNA","O54766",1153,0,"Zona pellucida sperm-binding protein 1",".",".",".",".","pfam00100","Zona_pellucida","Zona pellucida-like domain.","GO:0007338|single fertilization;","GO:0005576|extracellular region;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0035805|egg coat;GO:0062023|collagen-containing extracellular matrix;","GO:0035804|structural constituent of egg coat;","K19926","ZP1; zona pellucida sperm-binding protein 1"]
["ENSRNOG00000008001",30,1.929913146,7,0.451933018,4.270352177,2.094355054,{"v":9.31965e-05,"d":"9.32E-05"},{"v":6.47929e-05,"d":"6.48E-05"},"up","yes","Rab3b","protein_coding","chr5:123644423-123697401:+","gi|564352032|ref|XP_006238593.1|",1233,{"v":2e-168,"d":"2.00E-168"},"PREDICTED: ras-related protein Rab-3B isoform X1 [Rattus norvegicus]","gi|672053258|ref|XM_006238531.2|",1051,0,"PREDICTED: Rattus norvegicus RAB3B, member RAS oncogene family (Rab3b), transcript variant X1, mRNA","Q63941",450,{"v":2e-158,"d":"2.00E-158"},"Ras-related protein Rab-3B",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0006904|vesicle docking involved in exocytosis;GO:0009306|protein secretion;GO:0017157|regulation of exocytosis;GO:0018125|peptidyl-cysteine methylation;GO:0019882|antigen processing and presentation;GO:0051586|positive regulation of dopamine uptake involved in synaptic transmission;GO:0072659|protein localization to plasma membrane;GO:0097494|regulation of vesicle size;GO:0098693|regulation of synaptic vesicle cycle;","GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0008021|synaptic vesicle;GO:0030141|secretory granule;GO:0031982|vesicle;GO:0048471|perinuclear region of cytoplasm;GO:0098691|dopaminergic synapse;GO:0098993|anchored component of synaptic vesicle membrane;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0019003|GDP binding;GO:0030742|GTP-dependent protein binding;GO:0031489|myosin V binding;","K06108","RAB3B; Ras-related protein Rab-3B"]
["ENSRNOG00000019339",41,2.637547966,13,0.839304176,3.142541217,1.651931667,1.00113E-4,{"v":6.94579e-05,"d":"6.95E-05"},"up","yes","Ttll11","protein_coding","chr3:19110284-19335969:-","gi|392346263|ref|XP_001071863.3|",3596,0,"PREDICTED: tubulin polyglutamylase TTLL11 isoform X3 [Rattus norvegicus]","gi|672045460|ref|XM_001071863.5|",2101,0,"PREDICTED: Rattus norvegicus tubulin tyrosine ligase-like family, member 11 (Ttll11), transcript variant X3, mRNA","A4Q9F4",1228,0,"Tubulin polyglutamylase TTLL11",".",".",".",".","pfam03133","TTL","Tubulin-tyrosine ligase family. Tubulins and microtubules are subjected to several post-translational modifications of which the reversible detyrosination/tyrosination of the carboxy-terminal end of most alpha-tubulins has been extensively analysed. This modification cycle involves a specific carboxypeptidase and the activity of the tubulin-tyrosine ligase (TTL). The true physiological function of TTL has so far not been established. Tubulin-tyrosine ligase (TTL) catalyses the ATP-dependent post-translational addition of a tyrosine to the carboxy terminal end of detyrosinated alpha-tubulin. In normally cycling cells, the tyrosinated form of tubulin predominates. However, in breast cancer cells, the detyrosinated form frequently predominates, with a correlation to tumor aggressiveness. On the other hand, 3-nitrotyrosine has been shown to be incorporated, by TTL, into the carboxy terminal end of detyrosinated alpha-tubulin. This reaction is not reversible by the carboxypeptidase enzyme. Cells cultured in 3-nitrotyrosine rich medium showed evidence of altered microtubule structure and function, including altered cell morphology, epithelial barrier dysfunction, and apoptosis. Bacterial homologs of TTL are predicted to form peptide tags. Some of these are fused to a 2-oxoglutarate Fe(II)-dependent dioxygenase domain.","GO:0018095|protein polyglutamylation;GO:0051013|microtubule severing;","GO:0036064|ciliary basal body;",".","K16604","TTLL11; tubulin polyglutamylase TTLL11 [EC:6.3.2.-]"]
["ENSRNOG00000002471",80,5.146435055,38,2.453350667,2.097716859,1.068819962,1.003E-4,{"v":6.95537e-05,"d":"6.96E-05"},"up","yes","Polq","protein_coding","chr11:63673816-63775878:-","gi|157786800|ref|NP_001099348.1|",12889,0,"DNA polymerase theta [Rattus norvegicus]","gi|157786799|ref|NM_001105878.1|",8524,0,"Rattus norvegicus polymerase (DNA directed), theta (Polq), mRNA","Q8CGS6",4273,0,"DNA polymerase theta","MA3203",222,{"v":1E-58,"d":"1.00E-58"},"COG1204","pfam00476","DNA_pol_A","DNA polymerase family A.","GO:0006261|DNA-dependent DNA replication;GO:0006281|DNA repair;GO:0006284|base-excision repair;GO:0006302|double-strand break repair;GO:0006974|cellular response to DNA damage stimulus;GO:0016446|somatic hypermutation of immunoglobulin genes;GO:0032508|DNA duplex unwinding;GO:0051260|protein homooligomerization;GO:0071897|DNA biosynthetic process;GO:0097681|double-strand break repair via alternative nonhomologous end joining;GO:2000042|negative regulation of double-strand break repair via homologous recombination;","GO:0005654|nucleoplasm;GO:0005794|Golgi apparatus;GO:0005829|cytosol;","GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003887|DNA-directed DNA polymerase activity;GO:0005524|ATP binding;GO:0017116|single-stranded DNA-dependent ATP-dependent DNA helicase activity;GO:0042802|identical protein binding;GO:0051575|5'-deoxyribose-5-phosphate lyase activity;","K02349","POLQ; DNA polymerase theta [EC:2.7.7.7]"]
["ENSRNOG00000068860",51,3.280852347,19,1.226675333,2.674588995,1.419317209,1.03921E-4,{"v":7.19335e-05,"d":"7.19E-05"},"up","yes","ENSRNOG00000068860","protein_coding","chr6:15424590-15427213:-","gi|149050617|gb|EDM02790.1|",1636,0,"rCG61765 [Rattus norvegicus]","gi|672055163|ref|XM_008764422.1|",1079,0,"PREDICTED: Rattus norvegicus regulator of microtubule dynamics 2 (Rmdn2), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam07023","DUF1315","Protein of unknown function (DUF1315). This family consists of several bacterial proteins of around 90 residues in length. The function of this family is unknown.",".",".",".",".","."]
["ENSRNOG00000001407",62,3.988487167,26,1.678608351,2.37606775,1.248575973,1.05474E-4,{"v":7.29734e-05,"d":"7.30E-05"},"up","yes","Tfr2","protein_coding","chr12:19107673-19124591:-","gi|564378828|ref|XP_006249178.1|",4004,0,"PREDICTED: transferrin receptor protein 2 isoform X2 [Rattus norvegicus]","gi|157786883|ref|NM_001105916.1|",2964,0,"Rattus norvegicus transferrin receptor 2 (Tfr2), mRNA","B2GUY2",1531,0,"Transferrin receptor protein 2",".",".",".",".","pfam04253","TFR_dimer","Transferrin receptor-like dimerization domain. This domain is involved in dimerization of the transferrin receptor as shown in its crystal structure.","GO:0006508|proteolysis;GO:0006898|receptor-mediated endocytosis;GO:0006953|acute-phase response;GO:0010039|response to iron ion;GO:0033572|transferrin transport;GO:0045807|positive regulation of endocytosis;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0055072|iron ion homeostasis;GO:0071281|cellular response to iron ion;GO:0090277|positive regulation of peptide hormone secretion;GO:1903319|positive regulation of protein maturation;","GO:0005575|cellular_component;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0031410|cytoplasmic vesicle;GO:1990712|HFE-transferrin receptor complex;","GO:0003674|molecular_function;GO:0004998|transferrin receptor activity;GO:0008235|metalloexopeptidase activity;GO:0039706|co-receptor binding;","K23910","TFR2; transferrin receptor protein 2"]
["ENSRNOG00000011729",21,1.350939202,3,0.193685579,6.974908556,2.802174303,1.09113E-4,{"v":7.53724e-05,"d":"7.54E-05"},"up","yes","Nxf2","protein_coding","chrX:98135950-98157089:-","gi|392343366|ref|XP_002727670.2|",3149,0,"PREDICTED: nuclear RNA export factor 2 isoform X1 [Rattus norvegicus]","gi|672032573|ref|XM_002727624.4|",2100,0,"PREDICTED: Rattus norvegicus nuclear RNA export factor 2 (Nxf2), transcript variant X1, mRNA","Q9GZY0",578,0,"Nuclear RNA export factor 2",".",".",".",".","pfam09162","Tap-RNA_bind","Tap, RNA-binding. Members of this family adopt a structure consisting of an alpha+beta sandwich with an antiparallel beta-sheet, arranged in a 2(beta-alpha-beta) motif. They are mainly found in mRNA export factors, and mediate the sequence nonspecific nuclear export of cellular mRNAs as well as the sequence-specific export of retroviral mRNAs bearing the constitutive transport element.","GO:0008150|biological_process;GO:0016973|poly(A)+ mRNA export from nucleus;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;","GO:0003674|molecular_function;GO:0003723|RNA binding;GO:0003729|mRNA binding;","K14284","NXF, TAP, MEX67; nuclear RNA export factor"]
["ENSRNOG00000021892",21,1.350939202,3,0.193685579,6.974908556,2.802174303,1.09113E-4,{"v":7.53724e-05,"d":"7.54E-05"},"up","yes","Ccdc38","protein_coding","chr7:28059798-28130441:+","gi|109481859|ref|XP_001080322.1|",2946,0,"PREDICTED: coiled-coil domain-containing protein 38 isoform X1 [Rattus norvegicus]","gi|672021556|ref|XM_001080322.3|",2296,0,"PREDICTED: Rattus norvegicus coiled-coil domain containing 38 (Ccdc38), transcript variant X1, mRNA","Q8CDN8",855,0,"Coiled-coil domain-containing protein 38",".",".",".",".","pfam13863","DUF4200","Domain of unknown function (DUF4200). This family is found in eukaryotes. It is a coiled-coil domain of unknwon function.",".","GO:0005813|centrosome;",".",".","."]
["ENSRNOG00000028348",21,1.350939202,3,0.193685579,6.974908556,2.802174303,1.09113E-4,{"v":7.53724e-05,"d":"7.54E-05"},"up","yes","Lhx8","protein_coding","chr2:243244961-243269416:-","gi|564339378|ref|XP_006233590.1|",1793,0,"PREDICTED: LIM/homeobox protein Lhx8 isoform X1 [Rattus norvegicus]","gi|672044562|ref|XM_006233528.2|",1778,0,"PREDICTED: Rattus norvegicus LIM homeobox 8 (Lhx8), transcript variant X1, mRNA","O35652",689,0,"LIM/homeobox protein Lhx8",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0007611|learning or memory;GO:0008585|female gonad development;GO:0021879|forebrain neuron differentiation;GO:0021884|forebrain neuron development;GO:0030182|neuron differentiation;GO:0042475|odontogenesis of dentin-containing tooth;","GO:0001674|female germ cell nucleus;GO:0005634|nucleus;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0046872|metal ion binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09375","LHX6_8; LIM homeobox protein 6/8"]
["ENSRNOG00000004843",84,5.403756808,41,2.647036246,2.041436651,1.029584799,0.000110725,{"v":7.63842e-05,"d":"7.64E-05"},"up","yes","Pole3","protein_coding","chr7:109236321-109236758:-","gi|532017852|ref|XP_005352678.1|",495,{"v":4e-61,"d":"4.00E-61"},"PREDICTED: DNA polymerase epsilon subunit 3 [Microtus ochrogaster]","gi|672022077|ref|XM_002726945.4|",438,0,"PREDICTED: Rattus norvegicus DNA-directed DNA polymerase epsilon 3 (LOC100362333), mRNA","Q5R4W3",195,{"v":2e-62,"d":"2.00E-62"},"DNA polymerase epsilon subunit 3",".",".",".",".","pfam00808","CBFD_NFYB_HMF","Histone-like transcription factor (CBF/NF-Y) and archaeal histone. This family includes archaebacterial histones and histone like transcription factors from eukaryotes.","GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0008622|epsilon DNA polymerase complex;","GO:0003674|molecular_function;GO:0046982|protein heterodimerization activity;","K02326","POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]"]
["ENSRNOG00000051180",54,3.473843662,21,1.355799053,2.562211306,1.35738946,1.1305E-4,{"v":7.79225e-05,"d":"7.79E-05"},"up","yes","Chchd2","protein_coding","chr9:94500432-94501128:-","gi|392350892|ref|XP_003750791.1|",478,{"v":5e-57,"d":"5.00E-57"},"PREDICTED: coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial [Rattus norvegicus]","gi|49615114|gb|AC118069.8|",697,0,"Rattus norvegicus 9 BAC CH230-343O14 (Children's Hospital Oakland Research Institute) complete sequence","Q9D1L0",169,{"v":8e-51,"d":"8.00E-51"},"Coiled-coil-helix-coiled-coil-helix domain-containing protein 2",".",".",".",".","pfam06747","CHCH","CHCH domain. we have identified a conserved motif in the LOC118487 protein that we have called the CHCH motif. Alignment of this protein with related members showed the presence of three subgroups of proteins, which are called the S (Small), N (N-terminal extended) and C (C-terminal extended) subgroups. All three sub-groups of proteins have in common that they contain a predicted conserved [coiled coil 1]-[helix 1]-[coiled coil 2]-[helix 2] domain (CHCH domain). Within each helix of the CHCH domain, there are two cysteines present in a C-X9-C motif. The N-group contains an additional double helix domain, and each helix contains the C-X9-C motif. This family contains a number of characterized proteins: Cox19 protein - a nuclear gene of Saccharomyces cerevisiae, codes for an 11-kDa protein (Cox19p) required for expression of cytochrome oxidase. Because cox19 mutants are able to synthesize the mitochondrial and nuclear gene products of cytochrome oxidase, Cox19p probably functions post-translationally during assembly of the enzyme. Cox19p is present in the cytoplasm and mitochondria, where it exists as a soluble intermembrane protein. This dual location is similar to what was previously reported for Cox17p, a low molecular weight copper protein thought to be required for maturation of the CuA centre of subunit 2 of cytochrome oxidase. Cox19p have four conserved potential metal ligands, these are three cysteines and one histidine. Mrp10 - belongs to the class of yeast mitochondrial ribosomal proteins that are essential for translation. Eukaryotic NADH-ubiquinone oxidoreductase 19 kDa (NDUFA8) subunit. The CHCH domain was previously called DUF657.","GO:0007005|mitochondrion organization;GO:0034599|cellular response to oxidative stress;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:1900037|regulation of cellular response to hypoxia;GO:1905448|positive regulation of mitochondrial ATP synthesis coupled electron transport;","GO:0005634|nucleus;GO:0005739|mitochondrion;GO:0005758|mitochondrial intermembrane space;","GO:0043565|sequence-specific DNA binding;","K22758","CHCHD2; coiled-coil-helix-coiled-coil-helix domain-containing protein 2"]
["ENSRNOG00000066766",57,3.666834977,23,1.484922772,2.469377563,1.304147439,0.000119934,{"v":8.2518e-05,"d":"8.25E-05"},"up","yes","ENSRNOG00000066766","protein_coding","chr14:4692271-4708839:+","gi|672027632|ref|XP_006221724.2|",2013,0,"PREDICTED: LOW QUALITY PROTEIN: guanylate-binding protein 6-like [Rattus norvegicus]","gi|672075863|ref|XM_006250610.2|",715,0,"PREDICTED: Rattus norvegicus guanylate-binding protein 6-like (LOC102554096), transcript variant X2, mRNA","Q6ZN66",523,{"v":2E-179,"d":"2.00E-179"},"Guanylate-binding protein 6",".",".",".",".","pfam02841","GBP_C","Guanylate-binding protein, C-terminal domain. Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.",".",".",".",".","."]
["ENSRNOG00000059840",37,2.380226213,11,0.710180456,3.351579436,1.744841128,1.2244E-4,{"v":8.41408e-05,"d":"8.41E-05"},"up","yes","Unc5a","protein_coding","chr17:9614838-9670526:-","gi|11559980|ref|NP_071542.1|",4546,0,"netrin receptor UNC5A precursor [Rattus norvegicus]","gi|568982913|ref|XM_006517037.1|",3335,0,"PREDICTED: Mus musculus unc-5 homolog A (C. elegans) (Unc5a), transcript variant X1, mRNA","Q8K1S4",1744,0,"Netrin receptor UNC5A",".",".",".",".","pfam00791","ZU5","ZU5 domain. Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.","GO:0006915|apoptotic process;GO:0007411|axon guidance;GO:0031175|neuron projection development;GO:0033564|anterior/posterior axon guidance;GO:0038007|netrin-activated signaling pathway;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0031226|intrinsic component of plasma membrane;GO:0032589|neuron projection membrane;GO:0032809|neuronal cell body membrane;GO:0045121|membrane raft;","GO:0005042|netrin receptor activity;","K07521","UNC5; netrin receptor unc-5"]
["ENSRNOG00000060021",37,2.380226213,11,0.710180456,3.351579436,1.744841128,1.2244E-4,{"v":8.41408e-05,"d":"8.41E-05"},"up","yes","Txlnb","protein_coding","chr1:12404859-12449975:+","gi|209529675|ref|NP_001129331.1|",2980,0,"beta-taxilin [Rattus norvegicus]","gi|209529674|ref|NM_001135859.1|",4044,0,"Rattus norvegicus taxilin beta (Txlnb), mRNA","Q8VBT1",927,0,"Beta-taxilin",".",".",".",".","pfam09728","Taxilin","Myosin-like coiled-coil protein. Taxilin contains an extraordinarily long coiled-coil domain in its C-terminal half and is ubiquitously expressed. It is a novel binding partner of several syntaxin family members and is possibly involved in Ca2+-dependent exocytosis in neuroendocrine cells. Gamma-taxilin, described as leucine zipper protein Factor Inhibiting ATF4-mediated Transcription (FIAT), localizes to the nucleus in osteoblasts and dimerises with ATF4 to form inactive dimers, thus inhibiting ATF4-mediated transcription.",".","GO:0005737|cytoplasm;","GO:0019905|syntaxin binding;",".","."]
["ENSRNOG00000050360",66,4.24580892,29,1.87229393,2.26770426,1.181232505,0.000128449,{"v":8.79524e-05,"d":"8.80E-05"},"up","yes","Urad","protein_coding","chr12:7709312-7718923:+","gi|109496535|ref|XP_001068703.1|",1126,{"v":3E-152,"d":"3.00E-152"},"PREDICTED: putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [Rattus norvegicus]","gi|672026479|ref|XM_001068703.4|",1052,0,"PREDICTED: Rattus norvegicus ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase (Urad), mRNA","Q283N4",275,{"v":3e-90,"d":"3.00E-90"},"2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase","CC2606",112,{"v":2e-28,"d":"2.00E-28"},"COG3195","pfam09349","OHCU_decarbox","OHCU decarboxylase. The proteins in this family are OHCU decarboxylase - enzymes of the purine catabolism that catalyse the conversion of OHCU into S(+)-allantoin. This is the third step of the conversion of uric acid (a purine derivative) to allantoin. Step one is catalysed by urate oxidase (pfam01014) and step two is catalysed by HIUases (pfam00576).","GO:0000255|allantoin metabolic process;GO:0006144|purine nucleobase metabolic process;GO:0006147|guanine catabolic process;GO:0006148|inosine catabolic process;GO:0006149|deoxyinosine catabolic process;GO:0006154|adenosine catabolic process;GO:0006157|deoxyadenosine catabolic process;GO:0006161|deoxyguanosine catabolic process;GO:0006196|AMP catabolic process;GO:0006204|IMP catabolic process;GO:0009114|hypoxanthine catabolic process;GO:0009115|xanthine catabolic process;GO:0019628|urate catabolic process;GO:0046038|GMP catabolic process;GO:0046055|dGMP catabolic process;GO:0046059|dAMP catabolic process;","GO:0005777|peroxisome;","GO:0016831|carboxy-lyase activity;GO:0051997|2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity;","K13485","PRHOXNB, URAD; 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [EC:4.1.1.97]"]
["ENSRNOG00000015401",14,0.900626135,0,0.03228093,27.89963422,4.802174303,0.000128951,{"v":8.82648e-05,"d":"8.83E-05"},"up","yes","Mapk4","protein_coding","chr18:67512807-67661842:-","gi|402794629|ref|NP_062192.1|",3015,0,"mitogen-activated protein kinase 4 [Rattus norvegicus]","gi|672083546|ref|XM_008772166.1|",4545,0,"PREDICTED: Rattus norvegicus mitogen-activated protein kinase 4 (Mapk4), transcript variant X1, mRNA","Q6P5G0",1152,0,"Mitogen-activated protein kinase 4",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0000165|MAPK cascade;GO:0006468|protein phosphorylation;GO:0035556|intracellular signal transduction;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0004674|protein serine/threonine kinase activity;GO:0004707|MAP kinase activity;GO:0005524|ATP binding;GO:0019901|protein kinase binding;GO:0042803|protein homodimerization activity;GO:0046982|protein heterodimerization activity;","K06855","MAPK4_6; mitogen-activated protein kinase 4/6 [EC:2.7.11.24]"]
["ENSRNOG00000063114",14,0.900626135,0,0.03228093,27.89963422,4.802174303,0.000128951,{"v":8.82648e-05,"d":"8.83E-05"},"up","yes","ENSRNOG00000063114","lncRNA","chr1:224187736-224189816:-",".",".",".",".","gi|46240889|gb|AC118249.11|",169,{"v":1e-81,"d":"1.00E-81"},"Mus musculus chromosome 19, clone RP23-397G23, complete sequence",".",".",".",".",".",".",".",".","pfam11045","YbjM","Putative inner membrane protein of Enterobacteriaceae. This family is conserved in the Enterobacteriaceae. It is a putative inner membrane protein, named YbjM, but the function is not known.",".",".",".",".","."]
["ENSRNOG00000068910",14,0.900626135,0,0.03228093,27.89963422,4.802174303,0.000128951,{"v":8.82648e-05,"d":"8.83E-05"},"up","yes","Olr157","protein_coding","chr1:158885881-158893038:+","gi|47576421|ref|NP_001000169.1|",1729,0,"olfactory receptor Olr157 [Rattus norvegicus]","gi|49615119|gb|AC113720.6|",3277,0,"Rattus norvegicus 1 BAC CH230-117B1 (Children's Hospital Oakland Research Institute) complete sequence","Q8NH57",591,0,"Putative olfactory receptor 52P1",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.",".",".",".",".","."]
["ENSRNOG00000063759",23,1.479600078,4,0.258247439,5.729389171,2.518381337,0.000131955,{"v":9.02558e-05,"d":"9.03E-05"},"up","yes","ENSRNOG00000063759","lncRNA","chr9:106024644-106026682:-","gi|56789200|gb|AAH88270.1|",147,5e-08,"Wash2 protein [Rattus norvegicus]","gi|672033602|ref|XM_008758262.1|",553,0,"PREDICTED: Rattus norvegicus WAS protein family homolog (Wash), transcript variant X1, mRNA","Q8VDD8",60.5,2E-8,"WASH complex subunit 1",".",".",".",".","pfam15557","CAF1-p150_N","CAF1 complex subunit p150, region binding to PCNA. CAF1-p150_N is part of the N-terminus of the CAF1 complex p150 subunit that binds to PCNA - proliferating cell nuclear antigen. The PCNA mediates the connection between CAF-1 and the DNA replication fork. The CAF1 complex is essential in human cells for the de novo deposition of histones H3 and H4 at the DNA replication fork.",".",".",".",".","."]
["ENSRNOG00000030788",52,3.345182786,20,1.291237193,2.590680321,1.373331004,1.32118E-4,{"v":9.03565e-05,"d":"9.04E-05"},"up","yes","Olr35","protein_coding","chr1:154041306-154043257:+","gi|47577201|ref|NP_001000121.1|",1277,{"v":2E-171,"d":"2.00E-171"},"olfactory receptor Olr35 [Rattus norvegicus]","gi|51372035|gb|AC115040.7|",967,0,"Mus musculus chromosome 7, clone RP24-281E19, complete sequence","A6NND4",433,{"v":3E-148,"d":"3.00E-148"},"Olfactory receptor 2AT4",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0050911|detection of chemical stimulus involved in sensory perception of smell;GO:0070374|positive regulation of ERK1 and ERK2 cascade;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004984|olfactory receptor activity;","K04257","OLFR; olfactory receptor"]
["ENSRNOG00000020908",82,5.275095931,40,2.582474386,2.042651791,1.03044329,0.00013231,{"v":9.04769e-05,"d":"9.05E-05"},"up","yes","Hrob","protein_coding","chr10:87206049-87222483:+","gi|564374252|ref|XP_006247391.1|",2921,0,"PREDICTED: uncharacterized protein C17orf53 homolog isoform X1 [Rattus norvegicus]","gi|672068707|ref|XM_006247329.2|",2719,0,"PREDICTED: Rattus norvegicus E2F1-inducible gene (LOC303566), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam15072","DUF4539","Domain of unknown function (DUF4539). This family of proteins is found in eukaryotes. Proteins in this family are typically between 230 and 625 amino acids in length.","GO:0000725|recombinational repair;GO:0000731|DNA synthesis involved in DNA repair;GO:0006974|cellular response to DNA damage stimulus;GO:0007292|female gamete generation;GO:0036297|interstrand cross-link repair;GO:0048232|male gamete generation;","GO:0005634|nucleus;GO:0090734|site of DNA damage;","GO:0003697|single-stranded DNA binding;",".","."]
["ENSRNOG00000016622",42,2.701878404,14,0.903866035,2.989246524,1.579781881,0.000137359,{"v":9.38063e-05,"d":"9.38E-05"},"up","yes","Ankra2","protein_coding","chrX:75939719-75941326:-","gi|46485431|ref|NP_997478.1|",1683,0,"ankyrin repeat family A protein 2 [Rattus norvegicus]","gi|564299675|ref|XM_003753510.2|",1095,0,"PREDICTED: Rattus norvegicus ankyrin repeat family A protein 2-like (LOC100910438), transcript variant X1, mRNA","Q2KI79",639,0,"Ankyrin repeat family A protein 2","all2748",89.4,{"v":7e-19,"d":"7.00E-19"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0010468|regulation of gene expression;GO:0043254|regulation of protein complex assembly;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016020|membrane;GO:0032991|protein-containing complex;","GO:0019901|protein kinase binding;GO:0031625|ubiquitin protein ligase binding;GO:0042826|histone deacetylase binding;GO:0050750|low-density lipoprotein particle receptor binding;","K21486","ANKRA2; ankyrin repeat family A protein 2"]
["ENSRNOG00000019680",42,2.701878404,14,0.903866035,2.989246524,1.579781881,0.000137359,{"v":9.38063e-05,"d":"9.38E-05"},"up","yes","Mst1","protein_coding","chr8:108768839-108773416:+","gi|564365338|ref|XP_006243768.1|",3856,0,"PREDICTED: hepatocyte growth factor-like protein isoform X1 [Rattus norvegicus]","gi|564365337|ref|XM_006243706.1|",2298,0,"PREDICTED: Rattus norvegicus Macrophage stimulating 1 (hepatocyte growth factor-like) (Mst1), transcript variant X1, mRNA","P26928",1361,0,"Hepatocyte growth factor-like protein","VC1649",73.9,{"v":7e-13,"d":"7.00E-13"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;GO:0007283|spermatogenesis;GO:0007566|embryo implantation;GO:0010628|positive regulation of gene expression;GO:0010758|regulation of macrophage chemotaxis;GO:0030317|flagellated sperm motility;GO:0030879|mammary gland development;GO:0033601|positive regulation of mammary gland epithelial cell proliferation;GO:0035978|histone H2A-S139 phosphorylation;GO:0045721|negative regulation of gluconeogenesis;GO:0046425|regulation of JAK-STAT cascade;GO:0060763|mammary duct terminal end bud growth;GO:0071456|cellular response to hypoxia;GO:1904036|negative regulation of epithelial cell apoptotic process;GO:2000479|regulation of cAMP-dependent protein kinase activity;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005773|vacuole;","GO:0005102|signaling receptor binding;GO:0019899|enzyme binding;GO:0030971|receptor tyrosine kinase binding;","K23441","MST1; hepatocyte growth factor-like protein"]
["ENSRNOG00000030160",73,4.696121987,34,2.195103228,2.139362708,1.097181098,1.47236E-4,0.000100168,"up","yes","Zfp819","protein_coding","chr1:94035679-94048760:+","gi|62078765|ref|NP_001014039.1|",3272,0,"zinc finger protein 175 [Rattus norvegicus]","gi|672036387|ref|XM_006229044.2|",2338,0,"PREDICTED: Rattus norvegicus zinc finger protein 819 (Zfp819), transcript variant X4, mRNA","Q9Y473",584,0,"Zinc finger protein 175",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;GO:0043065|positive regulation of apoptotic process;GO:0045892|negative regulation of transcription, DNA-templated;","GO:0005634|nucleus;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0046872|metal ion binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSRNOG00000070476",31,1.994243584,8,0.516494877,3.861110093,1.949015691,1.50118E-4,1.02032E-4,"up","yes","ENSRNOG00000070476","lncRNA","chr15:44659512-44683691:+",".",".",".",".","gi|354793148|gb|JN957649.1|",276,{"v":1e-140,"d":"1.00E-140"},"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Entpd4:tm1e(EUCOMM)Hmgu tm2e(EUCOMM)Hmgu; transgenic",".",".",".",".",".",".",".",".","pfam00629","MAM","MAM domain. An extracellular domain found in many receptors.",".",".",".",".","."]
["ENSRNOG00000030714",50,3.216521909,19,1.226675333,2.622146074,1.390748057,1.54115E-4,1.04586E-4,"up","yes","Bsn","protein_coding","chr8:108788542-108875819:-","gi|158749559|ref|NP_062019.2|",9561,0,"protein bassoon [Rattus norvegicus]","gi|3413503|emb|Y16563.1|",12246,0,"Rattus norvegicus mRNA for brain-specific synapse-associated protein, Bassoon","O88778",3650,0,"Protein bassoon",".",".",".",".","pfam05715","zf-piccolo","Piccolo Zn-finger. This (predicted) Zinc finger is found in the bassoon and piccolo proteins. There are eight conserved cysteines, suggesting that it coordinates two zinc ligands.","GO:0007010|cytoskeleton organization;GO:0007416|synapse assembly;GO:0008088|axo-dendritic transport;GO:0008090|retrograde axonal transport;GO:0035418|protein localization to synapse;GO:0048790|maintenance of presynaptic active zone structure;GO:0050808|synapse organization;GO:0098693|regulation of synaptic vesicle cycle;GO:0099526|presynapse to nucleus signaling pathway;GO:1904071|presynaptic active zone assembly;GO:1904666|regulation of ubiquitin protein ligase activity;","GO:0005798|Golgi-associated vesicle;GO:0005802|trans-Golgi network;GO:0008021|synaptic vesicle;GO:0009986|cell surface;GO:0014069|postsynaptic density;GO:0019898|extrinsic component of membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0030672|synaptic vesicle membrane;GO:0043025|neuronal cell body;GO:0044306|neuron projection terminus;GO:0045202|synapse;GO:0048786|presynaptic active zone;GO:0048788|cytoskeleton of presynaptic active zone;GO:0060076|excitatory synapse;GO:0060077|inhibitory synapse;GO:0097060|synaptic membrane;GO:0097470|ribbon synapse;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098686|hippocampal mossy fiber to CA3 synapse;GO:0098793|presynapse;GO:0098831|presynaptic active zone cytoplasmic component;GO:0098978|glutamatergic synapse;GO:0098982|GABA-ergic synapse;GO:1904115|axon cytoplasm;GO:1990257|piccolo-bassoon transport vesicle;","GO:0001222|transcription corepressor binding;GO:0005515|protein binding;GO:0045503|dynein light chain binding;GO:0046872|metal ion binding;GO:0098882|structural constituent of presynaptic active zone;",".","."]
["ENSRNOG00000000542",29,1.865582707,7,0.451933018,4.128007105,2.045445454,1.5421E-4,1.04638E-4,"up","yes","Dnah8","protein_coding","chr20:8692963-8946772:+","gi|14335446|gb|AAK60621.1|AF356520_1",23278,0,"axonemal dynein heavy chain 8 long form [Mus musculus]","gi|755555913|ref|XM_006523588.2|",10842,0,"PREDICTED: Mus musculus dynein, axonemal, heavy chain 8 (Dnah8), transcript variant X1, mRNA","Q91XQ0",8968,0,"Dynein heavy chain 8, axonemal","YKR054c",641,0,"COG5245","pfam03028","Dynein_heavy","Dynein heavy chain and region D6 of dynein motor. This family represents the C-terminal region of dynein heavy chain. The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained.","GO:0007018|microtubule-based movement;GO:0008150|biological_process;GO:0036158|outer dynein arm assembly;","GO:0005575|cellular_component;GO:0005874|microtubule;GO:0005930|axoneme;GO:0030286|dynein complex;GO:0036126|sperm flagellum;GO:0036157|outer dynein arm;GO:0097228|sperm principal piece;","GO:0003674|molecular_function;GO:0005524|ATP binding;GO:0008569|ATP-dependent microtubule motor activity, minus-end-directed;GO:0045505|dynein intermediate chain binding;GO:0051959|dynein light intermediate chain binding;","K10408","DNAH; dynein axonemal heavy chain"]
["ENSRNOG00000008157",40,2.573217527,13,0.839304176,3.065893871,1.616307757,0.000154951,1.05104E-4,"up","yes","Syn2","protein_coding","chr4:148186270-148344192:+","gi|161168987|ref|NP_001104485.1|",2230,0,"synapsin-2 isoform IIa [Mus musculus]","gi|77404241|ref|NM_001034020.1|",2617,0,"Rattus norvegicus synapsin II (Syn2), transcript variant 1, mRNA","Q64332",835,0,"Synapsin-2",".",".",".",".","pfam02750","Synapsin_C","Synapsin, ATP binding domain. Ca dependent ATP binding in this ATP grasp fold. Function unknown.","GO:0007269|neurotransmitter secretion;GO:0017156|calcium ion regulated exocytosis;GO:0046928|regulation of neurotransmitter secretion;GO:0097091|synaptic vesicle clustering;GO:0099504|synaptic vesicle cycle;","GO:0005886|plasma membrane;GO:0008021|synaptic vesicle;GO:0014069|postsynaptic density;GO:0030672|synaptic vesicle membrane;GO:0031201|SNARE complex;GO:0043195|terminal bouton;GO:0045202|synapse;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098850|extrinsic component of synaptic vesicle membrane;GO:0098978|glutamatergic synapse;","GO:0005515|protein binding;GO:0005524|ATP binding;GO:0008092|cytoskeletal protein binding;GO:0042802|identical protein binding;GO:0048306|calcium-dependent protein binding;","K19941","SYN; synapsin"]
["ENSRNOG00000056746",40,2.573217527,13,0.839304176,3.065893871,1.616307757,0.000154951,1.05104E-4,"up","yes","Tchh","protein_coding","chr2:179109609-179110985:+","gi|672015998|ref|XP_008773413.1|",212,{"v":1e-15,"d":"1.00E-15"},"PREDICTED: trichohyalin isoform X3 [Rattus norvegicus]","gi|672043308|ref|XM_006232820.2|",547,0,"PREDICTED: Rattus norvegicus trichohyalin (Tchh), transcript variant X1, mRNA","P37709",67.4,{"v":8e-11,"d":"8.00E-11"},"Trichohyalin",".",".",".",".","pfam03814","KdpA","Potassium-transporting ATPase A subunit.","GO:0045109|intermediate filament organization;",".","GO:0005509|calcium ion binding;GO:0030674|protein binding, bridging;GO:0046914|transition metal ion binding;","K18626","TCHH; trichohyalin"]
["ENSRNOG00000024197",45,2.894869718,16,1.032989754,2.802418616,1.486672477,1.60328E-4,1.08557E-4,"up","yes","AABR07049149.1","protein_coding","chr5:103767458-103767925:-","gi|56090351|ref|NP_001007738.1|",579,{"v":2E-73,"d":"2.00E-73"},"uncharacterized protein C9orf85 homolog [Rattus norvegicus]","gi|56090350|ref|NM_001007737.1|",459,0,"Rattus norvegicus similar to RIKEN cDNA 1110059E24 (RGD1359158), mRNA",".",".",".",".",".",".",".",".","pfam10217","DUF2039","Uncharacterized conserved protein (DUF2039). This entry is a region of approximately 100 residues containing three pairs of cysteine residues. The region is conserved from plants to humans but its function is unknown.",".",".",".",".","."]
["ENSRNOG00000071113",45,2.894869718,16,1.032989754,2.802418616,1.486672477,1.60328E-4,1.08557E-4,"up","yes","ENSRNOG00000071113","protein_coding","chr7:89437557-89446328:-","gi|674066742|ref|XP_008840320.1|",322,{"v":6E-34,"d":"6.00E-34"},"PREDICTED: 60S ribosomal protein L37 [Nannospalax galili]","gi|672059266|ref|XR_355676.2|",608,0,"PREDICTED: Rattus norvegicus 60S ribosomal protein L37-like (LOC100912472), ncRNA","P61928",119,{"v":1e-31,"d":"1.00E-31"},"60S ribosomal protein L37","YLR185w",74.3,{"v":4e-16,"d":"4.00E-16"},"COG2126","pfam01907","Ribosomal_L37e","Ribosomal protein L37e. This family includes ribosomal protein L37 from eukaryotes and archaebacteria. The family contains many conserved cysteines and histidines suggesting that this protein may bind to zinc.",".",".",".",".","."]
["ENSRNOG00000013262",15,0.964956573,1,0.06456186,14.94623262,3.901709976,0.000167571,1.1326E-4,"up","yes","Myl1","protein_coding","chr9:68437517-68458261:-","gi|149016008|gb|EDL75289.1|",942,{"v":3E-122,"d":"3.00E-122"},"fast myosin alkali light chain, isoform CRA_c [Rattus norvegicus]","gi|298896366|emb|FQ215500.1|",1532,0,"Rattus norvegicus TL0ACA48YA04 mRNA sequence","P02600",291,{"v":3e-94,"d":"3.00E-94"},"Myosin light chain 1/3, skeletal muscle isoform","SPAC3A12.14",106,{"v":6e-26,"d":"6.00E-26"},"COG5126","pfam13499","EF-hand_7","EF-hand domain pair.","GO:0006936|muscle contraction;GO:0060048|cardiac muscle contraction;","GO:0016459|myosin complex;GO:0030016|myofibril;GO:0043292|contractile fiber;","GO:0005509|calcium ion binding;GO:0008307|structural constituent of muscle;","K05738","MYL1; myosin light chain 1"]
["ENSRNOG00000039396",15,0.964956573,1,0.06456186,14.94623262,3.901709976,0.000167571,1.1326E-4,"up","yes","Btnl3","protein_coding","chr20:4474056-4489024:-","gi|261599028|ref|NP_001002803.2|",2517,0,"butyrophilin-like protein 1 [Rattus norvegicus]","gi|261599027|ref|NM_001002803.2|",2040,0,"Rattus norvegicus butyrophilin-like 3 (Btnl3), mRNA","Q7TST0",793,0,"Butyrophilin-like protein 1",".",".",".",".","pfam00622","SPRY","SPRY domain. SPRY Domain is named from SPla and the RYanodine Receptor. Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.","GO:0001817|regulation of cytokine production;GO:0050852|T cell receptor signaling pathway;","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0005102|signaling receptor binding;","K06712","BTN, CD277; butyrophilin"]
["ENSRNOG00000006575",74,4.760452426,35,2.259665088,2.106707074,1.074989729,0.00017078,1.15375E-4,"up","yes","Ccdc96","protein_coding","chr14:74276960-74278888:-","gi|109499890|ref|XP_223518.4|",2172,0,"PREDICTED: coiled-coil domain-containing protein 96 [Rattus norvegicus]","gi|672028047|ref|XM_001063560.4|",1711,0,"PREDICTED: Rattus norvegicus coiled-coil domain containing 96 (Ccdc96), mRNA","Q9CR92",693,0,"Coiled-coil domain-containing protein 96",".",".",".",".","pfam13870","DUF4201","Domain of unknown function (DUF4201). This is a family of coiled-coil proteins from eukaryotes. The function is not known.","GO:0060271|cilium assembly;","GO:0005930|axoneme;GO:0036064|ciliary basal body;",".",".","."]
["ENSRNOG00000013290",59,3.795495853,25,1.614046491,2.351540599,1.23360624,0.000178948,1.20764E-4,"up","yes","Nrip3","protein_coding","chr1:163789738-163815600:-","gi|49117530|gb|AAH72641.1|",1172,{"v":5e-147,"d":"5.00E-147"},"Nrip3 protein [Mus musculus]","gi|157817419|ref|NM_001108498.1|",3770,0,"Rattus norvegicus nuclear receptor interacting protein 3 (Nrip3), mRNA","Q9JJR9",427,{"v":7e-138,"d":"7.00E-138"},"Nuclear receptor-interacting protein 3",".",".",".",".","pfam09668","Asp_protease","Aspartyl protease. This family of eukaryotic aspartyl proteases have a fold similar to retroviral proteases which implies they function proteolytically during regulated protein turnover.","GO:0006508|proteolysis;",".","GO:0004190|aspartic-type endopeptidase activity;",".","."]
["ENSRNOG00000046132",62,3.988487167,27,1.743170211,2.288065241,1.194128189,0.000181329,1.22328E-4,"up","yes","AABR07024439.1","protein_coding","chr16:35586200-35651524:-","gi|672063869|ref|XP_008764956.1|",734,{"v":2e-94,"d":"2.00E-94"},"PREDICTED: disks large homolog 5-like isoform X1 [Rattus norvegicus]","gi|672087250|ref|XR_597568.1|",196,{"v":2e-96,"d":"2.00E-96"},"PREDICTED: Rattus norvegicus hypothetical protein LOC680236 (LOC680236), transcript variant X3, misc_RNA",".",".",".",".",".",".",".",".","pfam04822","Takusan","Takusan. This domain is named takusan, which is a Japanese word meaning 'many'. Members of this family regulate synaptic activity.",".",".",".",".","."]
["ENSRNOG00000049446",78,5.017774178,38,2.453350667,2.045273937,1.032294086,0.000189041,0.000127245,"up","yes","ENSRNOG00000049446","protein_coding","chr14:4869196-4938277:-","gi|295444960|ref|NP_001171380.1|",394,{"v":1e-44,"d":"1.00E-44"},"rCG37858-like [Rattus norvegicus]","gi|295444959|ref|NM_001177909.1|",313,{"v":3e-161,"d":"3.00E-161"},"Rattus norvegicus rCG37858-like (LOC100366030), mRNA","E9QAG8",106,{"v":3E-24,"d":"3.00E-24"},"Zinc finger protein 431",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006355|regulation of transcription, DNA-templated;",".",".",".","."]
["ENSRNOG00000030522",72,4.631791549,34,2.195103228,2.11005637,1.077281541,0.000203997,0.000136989,"up","yes","ENSRNOG00000030522","protein_coding","chr4:162009857-162024625:+","gi|66730461|ref|NP_001019508.1|",1123,{"v":1e-149,"d":"1.00E-149"},"C-type lectin domain family 2 member D-related protein [Rattus norvegicus]","gi|66730460|ref|NM_001024337.1|",1434,0,"Rattus norvegicus similar to osteoclast inhibitory lectin (LOC500331), mRNA","Q5M9I1",437,{"v":5E-151,"d":"5.00E-151"},"C-type lectin domain family 2 member D-related protein",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type",".","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0030246|carbohydrate binding;GO:0046703|natural killer cell lectin-like receptor binding;",".","."]
["ENSRNOG00000000605",34,2.187234898,10,0.645618597,3.387812727,1.760354127,0.000211443,0.000141806,"up","yes","Hs3st5","protein_coding","chr20:40106876-40417653:+","gi|157822673|ref|NP_001099862.1|",1751,0,"heparan sulfate glucosamine 3-O-sulfotransferase 5 [Rattus norvegicus]","gi|157822672|ref|NM_001106392.1|",3043,0,"Rattus norvegicus heparan sulfate-glucosamine 3-sulfotransferase 5 (Hs3st5), mRNA","Q8BSL4",672,0,"Heparan sulfate glucosamine 3-O-sulfotransferase 5",".",".",".",".","pfam00685","Sulfotransfer_1","Sulfotransferase domain.","GO:0006477|protein sulfation;GO:0015015|heparan sulfate proteoglycan biosynthetic process, enzymatic modification;GO:0046596|regulation of viral entry into host cell;GO:0050819|negative regulation of coagulation;","GO:0005794|Golgi apparatus;","GO:0008467|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity;","K08104","HS3ST5; [heparan sulfate]-glucosamine 3-sulfotransferase 5 [EC:2.8.2.23]"]
["ENSRNOG00000008806",49,3.152191471,19,1.226675333,2.569703152,1.361601711,0.000227477,0.000152023,"up","yes","Clip4","protein_coding","chr6:23616281-23677874:-","gi|62078611|ref|NP_001013964.1|",2363,0,"CAP-Gly domain-containing linker protein 4 [Rattus norvegicus]","gi|62078610|ref|NM_001013942.1|",1444,0,"Rattus norvegicus CAP-GLY domain containing linker protein family, member 4 (Clip4), mRNA","Q66HD5",914,0,"CAP-Gly domain-containing linker protein 4","YPL174c",70.9,{"v":6e-12,"d":"6.00E-12"},"COG5244","pfam01302","CAP_GLY","CAP-Gly domain. Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove.","GO:0031122|cytoplasmic microtubule organization;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0035371|microtubule plus-end;GO:0043231|intracellular membrane-bounded organelle;","GO:0051010|microtubule plus-end binding;","K10423","CLIP3_4; CAP-Gly domain-containing linker protein 3/4"]
["ENSRNOG00000016835",22,1.41526964,4,0.258247439,5.480285294,2.454250999,2.29366E-4,1.53268E-4,"up","yes","Sycp1","protein_coding","chr2:190296954-190456737:-","gi|149030467|gb|EDL85504.1|",4558,0,"synaptonemal complex protein 1, isoform CRA_a [Rattus norvegicus]","gi|6981615|ref|NM_012810.1|",3230,0,"Rattus norvegicus synaptonemal complex protein 1 (Sycp1), mRNA","Q03410",1756,0,"Synaptonemal complex protein 1",".",".",".",".","pfam05483","SCP-1","Synaptonemal complex protein 1 (SCP-1). Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.","GO:0000711|meiotic DNA repair synthesis;GO:0007129|synapsis;GO:0007130|synaptonemal complex assembly;GO:0007131|reciprocal meiotic recombination;GO:0007283|spermatogenesis;GO:0032880|regulation of protein localization;GO:0035092|sperm chromatin condensation;GO:0051026|chiasma assembly;GO:0051289|protein homotetramerization;GO:0051301|cell division;GO:0051878|lateral element assembly;","GO:0000775|chromosome, centromeric region;GO:0000794|condensed nuclear chromosome;GO:0000795|synaptonemal complex;GO:0000801|central element;GO:0000802|transverse filament;GO:0001673|male germ cell nucleus;GO:0005634|nucleus;GO:0005694|chromosome;","GO:0003690|double-stranded DNA binding;","K19533","SYCP1; synaptonemal complex protein 1"]
["ENSRNOG00000008849",13,0.836295696,0,0.03228093,25.90680321,4.695259099,0.000238312,1.58689E-4,"up","yes","Guca2a","protein_coding","chr5:133237177-133239018:+","gi|6980994|ref|NP_037250.1|",484,{"v":4e-59,"d":"4.00E-59"},"guanylin precursor [Rattus norvegicus]","gi|6980993|ref|NM_013118.1|",557,0,"Rattus norvegicus guanylate cyclase activator 2A (Guca2a), mRNA","P28902",191,{"v":1e-60,"d":"1.00E-60"},"Guanylin",".",".",".",".","pfam02058","Guanylin","Guanylin precursor.","GO:0031284|positive regulation of guanylate cyclase activity;","GO:0005576|extracellular region;","GO:0030249|guanylate cyclase regulator activity;GO:0030250|guanylate cyclase activator activity;","K25556","GUCA2; guanylate cyclase activator 2"]
["ENSRNOG00000012750",13,0.836295696,0,0.03228093,25.90680321,4.695259099,0.000238312,1.58689E-4,"up","yes","Pabpc1l","protein_coding","chr3:152693700-152725997:+","gi|392346932|ref|XP_230831.6|",3125,0,"PREDICTED: polyadenylate-binding protein 1-like isoform X2 [Rattus norvegicus]","gi|672048257|ref|XM_230831.8|",1830,0,"PREDICTED: Rattus norvegicus poly(A) binding protein, cytoplasmic 1-like (Pabpc1l), transcript variant X2, mRNA","Q4VXU2",908,0,"Polyadenylate-binding protein 1-like",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0001556|oocyte maturation;GO:0006338|chromatin remodeling;GO:0006378|mRNA polyadenylation;GO:0048096|chromatin-mediated maintenance of transcription;GO:0051647|nucleus localization;","GO:0005634|nucleus;GO:0005829|cytosol;GO:0010494|cytoplasmic stress granule;GO:1990904|ribonucleoprotein complex;","GO:0003723|RNA binding;GO:0003730|mRNA 3'-UTR binding;GO:0008143|poly(A) binding;GO:0008266|poly(U) RNA binding;","K13126","PABPC; polyadenylate-binding protein"]
["ENSRNOG00000048230",13,0.836295696,0,0.03228093,25.90680321,4.695259099,0.000238312,1.58689E-4,"up","yes","ENSRNOG00000048230","protein_coding","chr7:15821379-15838813:+","gi|392349284|ref|XP_234980.5|",2159,0,"PREDICTED: sperm motility kinase W-like [Rattus norvegicus]","gi|672058325|ref|XR_593312.1|",1678,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102557062 (LOC102557062), transcript variant X7, ncRNA","Q8C0V7",577,0,"Putative sperm motility kinase W",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006468|protein phosphorylation;GO:0035556|intracellular signal transduction;GO:0043066|negative regulation of apoptotic process;","GO:0005737|cytoplasm;","GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;",".","."]
["ENSRNOG00000064961",39,2.508887089,13,0.839304176,2.989246524,1.579781881,0.000238616,0.000158873,"up","yes","ENSRNOG00000064961","lncRNA","chr3:140486224-140488668:-","gi|759100021|ref|XP_011375277.1|",330,{"v":2e-33,"d":"2.00E-33"},"PREDICTED: LOW QUALITY PROTEIN: 40S ribosomal protein S29 [Pteropus vampyrus]","gi|298901498|emb|FQ221640.1|",338,{"v":4E-175,"d":"4.00E-175"},"Rattus norvegicus TL0ADA33YJ17 mRNA sequence","P62275",120,{"v":4e-32,"d":"4.00E-32"},"40S ribosomal protein S29","YLR388w",83.2,{"v":3e-19,"d":"3.00E-19"},"COG0199","pfam00253","Ribosomal_S14","Ribosomal protein S14p/S29e. This family includes both ribosomal S14 from prokaryotes and S29 from eukaryotes.",".",".",".",".","."]
["ENSRNOG00000067240",52,3.345182786,21,1.355799053,2.467314591,1.302941676,0.000241543,0.000160709,"up","yes","ENSRNOG00000067240","protein_coding","chr9:9954138-10010311:-","gi|45478228|gb|AAS66285.1|",782,0,"LRRGT00194 [Rattus norvegicus]","gi|672077211|ref|XM_008770438.1|",1986,0,"PREDICTED: Rattus norvegicus similar to RIKEN cDNA 1700001E04 (LOC301748), transcript variant X2, mRNA","O00370",235,{"v":5e-136,"d":"5.00E-136"},"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam04822","Takusan","Takusan. This domain is named takusan, which is a Japanese word meaning 'many'. Members of this family regulate synaptic activity.",".",".",".",".","."]
["ENSRNOG00000069485",52,3.345182786,21,1.355799053,2.467314591,1.302941676,0.000241543,0.000160709,"up","yes","ENSRNOG00000069485","lncRNA","chr20:6549166-6575490:-",".",".",".",".","gi|672086007|ref|XM_006256224.2|",753,0,"PREDICTED: Rattus norvegicus FK506 binding protein 5 (Fkbp5), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam05110","AF-4","AF-4 proto-oncoprotein. This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.",".",".",".",".","."]
["ENSRNOG00000001251",24,1.543930516,5,0.322809298,4.782794438,2.257853786,0.000249565,0.000165795,"up","yes","Grifin","protein_coding","chr12:14080910-14082877:+","gi|149035009|gb|EDL89729.1|",758,{"v":4e-100,"d":"4.00E-100"},"galectin-related inter-fiber protein, isoform CRA_b [Rattus norvegicus]","gi|451958076|ref|NM_057187.2|",553,0,"Rattus norvegicus galectin-related inter-fiber protein (Grifin), mRNA","O88644",295,{"v":6e-101,"d":"6.00E-101"},"Grifin",".",".",".",".","pfam00337","Gal-bind_lectin","Galactoside-binding lectin. This family contains galactoside binding lectins.   The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).",".","GO:0005737|cytoplasm;","GO:0030246|carbohydrate binding;",".","."]
["ENSRNOG00000056287",28,1.801252269,7,0.451933018,3.985662032,1.994819381,0.0002539,0.000168342,"up","yes","Snora26","snoRNA","chr14:34127640-34127760:-","gi|26337233|dbj|BAC32301.1|",189,{"v":1e-16,"d":"1.00E-16"},"unnamed protein product [Mus musculus]","gi|222350115|emb|FM991919.1|",106,{"v":3e-47,"d":"3.00E-47"},"Mus musculus AK172090 snRNA, strain C57BL/6J",".",".",".",".",".",".",".",".","pfam12834","Phage_int_SAM_2","Phage integrase, N-terminal. This is a family of DNA-binding prophage integrases. It is found largely in Proteobacteria.",".",".",".",".","."]
["ENSRNOG00000070972",28,1.801252269,7,0.451933018,3.985662032,1.994819381,0.0002539,0.000168342,"up","yes","ENSRNOG00000070972","protein_coding","chr15:4625982-4688858:-","gi|564385445|ref|XP_006251744.1|",1093,{"v":3e-145,"d":"3.00E-145"},"PREDICTED: uncharacterized protein LOC102547093 isoform X2 [Rattus norvegicus]","gi|672028263|ref|XM_006221886.2|",1096,0,"PREDICTED: Rattus norvegicus disks large homolog 5-like (LOC102547212), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam04822","Takusan","Takusan. This domain is named takusan, which is a Japanese word meaning 'many'. Members of this family regulate synaptic activity.",".",".",".",".","."]
["ENSRNOG00000004484",58,3.731165415,25,1.614046491,2.311683979,1.208944186,0.000255733,0.000169439,"up","yes","Commd5","protein_coding","chr7:108598673-108624764:+","gi|564360784|ref|XP_006241977.1|",1151,{"v":4e-145,"d":"4.00E-145"},"PREDICTED: COMM domain-containing protein 5 [Rattus norvegicus]","gi|672059684|ref|XM_006241916.2|",1611,0,"PREDICTED: Rattus norvegicus COMM domain-containing protein 5-like (LOC100910472), transcript variant X2, mRNA","Q9ERR2",442,{"v":1e-144,"d":"1.00E-144"},"COMM domain-containing protein 5",".",".",".",".","pfam07258","HCaRG","HCaRG protein. This family consists of several mammalian HCaRG(hypertension-related, calcium-regulated gene) proteins. HCaRG is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals. HCaRG is a nuclear protein potentially involved in the control of cell proliferation.","GO:0030307|positive regulation of cell growth;GO:0030858|positive regulation of epithelial cell differentiation;GO:0051726|regulation of cell cycle;GO:0072158|proximal tubule morphogenesis;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;",".","K22561","COMMD5, HCARG; COMM domain containing 5"]
["ENSRNOG00000012686",58,3.731165415,25,1.614046491,2.311683979,1.208944186,0.000255733,0.000169439,"up","yes","Pomc","protein_coding","chr6:26939837-26945664:+","gi|149050847|gb|EDM03020.1|",1119,{"v":5E-151,"d":"5.00E-151"},"pro-opiomelanocortin, isoform CRA_b [Rattus norvegicus]","gi|40254726|ref|NM_139326.2|",932,0,"Rattus norvegicus proopiomelanocortin (Pomc), mRNA","P01194",416,{"v":3e-145,"d":"3.00E-145"},"Pro-opiomelanocortin",".",".",".",".","pfam08384","NPP","Pro-opiomelanocortin, N-terminal region. This family features the N-terminal peptide of pro-opiomelanocortin (NPP). It is thought to represent an important pituitary peptide, given its high yield from pituitary glands, and exhibits a potent in vitro aldosterone-stimulating activity.","GO:0006091|generation of precursor metabolites and energy;GO:0007165|signal transduction;GO:0007218|neuropeptide signaling pathway;GO:0007267|cell-cell signaling;GO:0007631|feeding behavior;GO:0008217|regulation of blood pressure;GO:0019722|calcium-mediated signaling;GO:0031640|killing of cells of other organism;GO:0032098|regulation of appetite;GO:0032720|negative regulation of tumor necrosis factor production;GO:0033059|cellular pigmentation;GO:0035821|modification of morphology or physiology of other organism;GO:0035902|response to immobilization stress;GO:0042593|glucose homeostasis;GO:0043400|cortisol secretion;GO:0043950|positive regulation of cAMP-mediated signaling;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070873|regulation of glycogen metabolic process;GO:0070965|positive regulation of neutrophil mediated killing of fungus;GO:1990680|response to melanocyte-stimulating hormone;GO:2000852|regulation of corticosterone secretion;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005782|peroxisomal matrix;GO:0030141|secretory granule;","GO:0001664|G protein-coupled receptor binding;GO:0003674|molecular_function;GO:0005102|signaling receptor binding;GO:0005179|hormone activity;GO:0031781|type 3 melanocortin receptor binding;GO:0031782|type 4 melanocortin receptor binding;GO:0070996|type 1 melanocortin receptor binding;","K05228","POMC; proopiomelanocortin"]
["ENSRNOG00000025233",37,2.380226213,12,0.774742316,3.07228115,1.619310246,0.000269235,0.000177993,"up","yes","Tcl1a","protein_coding","chr6:124125032-124131025:-","gi|575501723|ref|NP_001276397.1|",646,{"v":8E-79,"d":"8.00E-79"},"T-cell leukemia/lymphoma protein 1A isoform 2 [Mus musculus]","gi|157819356|ref|NM_001109601.1|",1324,0,"Rattus norvegicus T-cell leukemia/lymphoma 1A (Tcl1a), mRNA","P56280",170,{"v":2e-49,"d":"2.00E-49"},"T-cell leukemia/lymphoma protein 1A",".",".",".",".","pfam01840","TCL1_MTCP1","TCL1/MTCP1 family. Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell prolymphocytic leukaemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28. This family contains two repeated motifs that form a single globular domain.","GO:0008150|biological_process;GO:0008284|positive regulation of cell proliferation;GO:0010629|negative regulation of gene expression;GO:0010918|positive regulation of mitochondrial membrane potential;GO:0019827|stem cell population maintenance;GO:0031334|positive regulation of protein complex assembly;GO:0032148|activation of protein kinase B activity;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0043066|negative regulation of apoptotic process;GO:0071356|cellular response to tumor necrosis factor;GO:0071902|positive regulation of protein serine/threonine kinase activity;GO:2000036|regulation of stem cell population maintenance;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;GO:0005938|cell cortex;GO:0032991|protein-containing complex;GO:0045120|pronucleus;","GO:0003674|molecular_function;GO:0019901|protein kinase binding;GO:0042802|identical protein binding;GO:0043539|protein serine/threonine kinase activator activity;","K10167","TCL1A; T-cell leukemia/lymphoma 1A"]
["ENSRNOG00000063594",74,4.760452426,36,2.324226948,2.048187433,1.034347745,2.70337E-4,0.00017868,"up","yes","ENSRNOG00000063594","lncRNA","chr5:104003369-104008178:+","gi|148701441|gb|EDL33388.1|",227,{"v":1e-18,"d":"1.00E-18"},"mCG1045525, partial [Mus musculus]","gi|33942029|emb|AL831719.6|",285,{"v":4e-145,"d":"4.00E-145"},"Mouse DNA sequence from clone RP23-166I8 on chromosome 4, complete sequence","P46935",54.3,7e-06,"E3 ubiquitin-protein ligase NEDD4",".",".",".",".","pfam11188","DUF2975","Protein of unknown function (DUF2975). This family of bacterial proteins have no known function. These proteins are likely to be integral membrane proteins. The proteins contain a highly conserved glutamic acid close to their C-terminus.",".",".",".",".","."]
["ENSRNOG00000005309",53,3.409513224,22,1.420360912,2.400455542,1.263308217,0.000296634,0.000195406,"up","yes","Scn8a","protein_coding","chr7:131982480-132151292:+","gi|3309115|gb|AAC26015.1|",9077,0,"voltage-gated sodium channel variant rPN4a [Rattus norvegicus]","gi|3309114|gb|AF049240.1|AF049240",6552,0,"Rattus norvegicus voltage-gated sodium channel variant rPN4a mRNA, complete cds","O88420",3472,0,"Sodium channel protein type 8 subunit alpha",".",".",".",".","pfam06512","Na_trans_assoc","Sodium ion transport-associated. Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.","GO:0006814|sodium ion transport;GO:0007422|peripheral nervous system development;GO:0007517|muscle organ development;GO:0007605|sensory perception of sound;GO:0007626|locomotory behavior;GO:0007628|adult walking behavior;GO:0008344|adult locomotory behavior;GO:0009636|response to toxic substance;GO:0019228|neuronal action potential;GO:0034765|regulation of ion transmembrane transport;GO:0035725|sodium ion transmembrane transport;GO:0042552|myelination;GO:0050905|neuromuscular process;GO:0086010|membrane depolarization during action potential;","GO:0001518|voltage-gated sodium channel complex;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030018|Z disc;GO:0030054|cell junction;GO:0030424|axon;GO:0030425|dendrite;GO:0033268|node of Ranvier;GO:0034706|sodium channel complex;GO:0043025|neuronal cell body;GO:0043194|axon initial segment;GO:0098688|parallel fiber to Purkinje cell synapse;GO:0098978|glutamatergic synapse;GO:0099059|integral component of presynaptic active zone membrane;GO:0099061|integral component of postsynaptic density membrane;","GO:0005244|voltage-gated ion channel activity;GO:0005248|voltage-gated sodium channel activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0031402|sodium ion binding;","K04840","SCN8A, NAV1.6; voltage-gated sodium channel type VIII alpha"]
["ENSRNOG00000000473",65,4.181478482,30,1.93685579,2.158900267,1.110296598,0.000298896,0.000196759,"up","yes","Pfdn6","protein_coding","chr20:4945959-4947433:+","gi|545838985|ref|XP_005665938.1|",643,{"v":5e-82,"d":"5.00E-82"},"PREDICTED: prefoldin subunit 6 isoform X1 [Sus scrofa]","gi|257900464|ref|NM_001164718.1|",588,0,"Rattus norvegicus prefoldin subunit 6 (Pfdn6), mRNA","Q03958",244,{"v":2e-81,"d":"2.00E-81"},"Prefoldin subunit 6","YLR200w",79.3,{"v":5e-18,"d":"5.00E-18"},"COG1382","pfam01920","Prefoldin_2","Prefoldin subunit. This family includes prefoldin subunits that are not detected by pfam02996.","GO:0006457|protein folding;GO:0008150|biological_process;GO:0051131|chaperone-mediated protein complex assembly;GO:1905907|negative regulation of amyloid fibril formation;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0016272|prefoldin complex;","GO:0001540|amyloid-beta binding;GO:0003674|molecular_function;GO:0051082|unfolded protein binding;GO:0051087|chaperone binding;","K04798","pfdB, PFDN6; prefoldin beta subunit"]
["ENSRNOG00000032516",65,4.181478482,30,1.93685579,2.158900267,1.110296598,0.000298896,0.000196759,"up","yes","AABR07049223.1","protein_coding","chr5:106982882-106983121:-","gi|625242789|ref|XP_007612621.1|",350,{"v":2e-40,"d":"2.00E-40"},"PREDICTED: LOW QUALITY PROTEIN: cyclin-dependent kinases regulatory subunit 1-like [Cricetulus griseus]","gi|197245983|gb|BC168780.1|",237,{"v":1E-119,"d":"1.00E-119"},"Rattus norvegicus RGD1561797, mRNA (cDNA clone MGC:188935 IMAGE:6918892), complete cds","P61025",136,{"v":2E-41,"d":"2.00E-41"},"Cyclin-dependent kinases regulatory subunit 1",".",".",".",".","pfam01111","CKS","Cyclin-dependent kinase regulatory subunit.","GO:0045737|positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0051301|cell division;",".",".",".","."]
["ENSRNOG00000063146",35,2.251565336,11,0.710180456,3.17041298,1.664670779,0.00030135,0.000198101,"up","yes","Rab39a","protein_coding","chr8:54088129-54106483:-","gi|157822741|ref|NP_001101618.1|",1160,{"v":1e-152,"d":"1.00E-152"},"ras-related protein Rab-39A [Rattus norvegicus]","gi|133891651|ref|NM_175562.3|",1019,0,"Mus musculus RAB39, member RAS oncogene family (Rab39), mRNA","Q8BHD0",439,{"v":1e-149,"d":"1.00E-149"},"Ras-related protein Rab-39A",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.",".",".",".",".","."]
["ENSRNOG00000066520",35,2.251565336,11,0.710180456,3.17041298,1.664670779,0.00030135,0.000198101,"up","yes","ENSRNOG00000066520","protein_coding","chr9:20660322-20662313:-","gi|672023860|ref|XP_008756222.1|",225,{"v":8e-22,"d":"8.00E-22"},"PREDICTED: polyubiquitin 8-like isoform X1 [Rattus norvegicus]","gi|672064669|ref|XM_008766948.1|",123,{"v":2e-56,"d":"2.00E-56"},"PREDICTED: Rattus norvegicus polyubiquitin 12-like (LOC102557398), transcript variant X2, partial mRNA",".",".",".",".",".",".",".",".","pfam02141","DENN","DENN (AEX-3) domain. DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.",".",".",".",".","."]
["ENSRNOG00000049983",75,4.824782864,37,2.388788807,2.019761165,1.014184706,0.000308786,0.000202779,"up","yes","Shd","protein_coding","chr9:795674-808371:+","gi|157817626|ref|NP_001101693.1|",1677,0,"SH2 domain-containing adapter protein D [Rattus norvegicus]","gi|157817625|ref|NM_001108223.1|",1201,0,"Rattus norvegicus src homology 2 domain-containing transforming protein D (Shd), mRNA","O88834",611,0,"SH2 domain-containing adapter protein D",".",".",".",".","pfam04502","DUF572","Family of unknown function (DUF572). Family of eukaryotic proteins with undetermined function.",".",".","GO:0001784|phosphotyrosine residue binding;","K23697","SHB_D_E_F; SH2 domain-containing adapter protein B/D/E/F"]
["ENSRNOG00000040333",14,0.900626135,1,0.06456186,13.94981711,3.802174303,0.000312456,2.04954E-4,"up","yes","ENSRNOG00000040333","protein_coding","chr3:5756621-5987008:+","gi|149039457|gb|EDL93677.1|",1306,{"v":2E-180,"d":"2.00E-180"},"rCG45929 [Rattus norvegicus]","gi|672016681|ref|XM_008775346.1|",736,0,"PREDICTED: Rattus norvegicus neurexophilin 2 (Nxph2), partial mRNA","Q61199",452,{"v":4E-160,"d":"4.00E-160"},"Neurexophilin-2",".",".",".",".","pfam06312","Neurexophilin","Neurexophilin. This family consists of mammalian neurexophilin proteins. Mammalian brains contain four different neurexophilin proteins. Neurexophilins form a family of related glycoproteins that are proteolytically processed after synthesis and bind to alpha-neurexins. The structure and characteristics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins.",".","GO:0005576|extracellular region;",".","K16657","NXPH2; neurexophilin-2"]
["ENSRNOG00000066805",14,0.900626135,1,0.06456186,13.94981711,3.802174303,0.000312456,2.04954E-4,"up","yes","ENSRNOG00000066805","lncRNA","chrX:16297627-16300926:-","gi|148675219|gb|EDL07166.1|",171,{"v":4e-12,"d":"4.00E-12"},"mCG1028420, partial [Mus musculus]","gi|73760428|gb|AC159503.10|",169,{"v":4e-81,"d":"4.00E-81"},"Mus musculus 10 BAC RP24-293I2 (Roswell Park Cancer Institute (C57BL/6J Male) Mouse BAC Library) complete sequence",".",".",".",".",".",".",".",".","pfam09771","Tmemb_18A","Transmembrane protein 188. The function of this family of transmembrane proteins has not, as yet, been determined.",".",".",".",".","."]
["ENSRNOG00000069467",14,0.900626135,1,0.06456186,13.94981711,3.802174303,0.000312456,2.04954E-4,"up","yes","ENSRNOG00000069467","protein_coding","chr11:64896331-64896753:+","gi|149025948|gb|EDL82191.1|",305,{"v":6e-33,"d":"6.00E-33"},"caspase 6, isoform CRA_b [Rattus norvegicus]","gi|672044118|ref|XM_008761477.1|",147,{"v":1e-69,"d":"1.00E-69"},"PREDICTED: Rattus norvegicus caspase-6 (LOC103689977), transcript variant X2, mRNA","O08738",119,{"v":8e-33,"d":"8.00E-33"},"Caspase-6",".",".",".",".","pfam00656","Peptidase_C14","Caspase domain.",".",".",".",".","."]
["ENSRNOG00000070829",14,0.900626135,1,0.06456186,13.94981711,3.802174303,0.000312456,2.04954E-4,"up","yes","ENSRNOG00000070829","lncRNA","chr4:118778737-118786092:-","gi|149036607|gb|EDL91225.1|",455,{"v":5E-53,"d":"5.00E-53"},"rCG56442 [Rattus norvegicus]","gi|62079335|gb|AC155947.8|",154,{"v":7e-73,"d":"7.00E-73"},"Mus musculus 6 BAC RP24-417N21 (Roswell Park Cancer Institute (C57BL/6J Male) Mouse BAC Library) complete sequence","P46935",53.1,2e-06,"E3 ubiquitin-protein ligase NEDD4",".",".",".",".","pfam15262","DUF4592","Domain of unknown function (DUF4592). This protein family is a domain of unknown function, which lies to the N-terminus of the protein. This domain family is found in eukaryotes, and is typically between 114 and 130 amino acids in length. There are two completely conserved residues (L and A) that may be functionally important. In humans, the gene that encodes this protein lies in the position, chromosome 2 open reading frame 55.",".",".",".",".","."]
["ENSRNOG00000011552",40,2.573217527,14,0.903866035,2.846901451,1.509392553,0.000319662,2.09497E-4,"up","yes","Mon1b","protein_coding","chr19:41617364-41625347:+","gi|564395952|ref|XP_006255736.1|",2583,0,"PREDICTED: vacuolar fusion protein MON1 homolog B isoform X1 [Rattus norvegicus]","gi|672084884|ref|XM_006255674.2|",3205,0,"PREDICTED: Rattus norvegicus MON1 secretory trafficking family member B (Mon1b), transcript variant X2, mRNA","Q8BMQ8",957,0,"Vacuolar fusion protein MON1 homolog B",".",".",".",".","pfam03164","Mon1","Trafficking protein Mon1. Members of this family have been called SAND proteins although these proteins do not contain a SAND domain. In Saccharomyces cerevisiae a protein complex of Mon1 and Ccz1 functions with the small GTPase Ypt7 to mediate vesicle trafficking to the vacuole. The Mon1/Ccz1 complex is conserved in eukaryotic evolution and members of this family (previously known as DUF254) are distant homologues to domains of known structure that assemble into cargo vesicle adapter (AP) complexes. describes orthologues in Fugu rubripes.","GO:0006623|protein targeting to vacuole;GO:0016192|vesicle-mediated transport;GO:0019085|early viral transcription;GO:0019086|late viral transcription;","GO:0005737|cytoplasm;GO:0035658|Mon1-Ccz1 complex;",".","K20195","MON1; vacuolar fusion protein MON1"]
["ENSRNOG00000011141",33,2.12290446,10,0.645618597,3.288171176,1.717285405,0.000333968,0.000218262,"up","yes","Serpina11","protein_coding","chr6:122903250-122912670:-","gi|261599054|ref|NP_001159824.1|",2089,0,"serpin A11 isoform 2 precursor [Rattus norvegicus]","gi|261599053|ref|NM_001166352.1|",1463,0,"Rattus norvegicus serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 (Serpina11), transcript variant 2, mRNA","Q7TPA5",810,0,"Serpin A11","all0778",139,{"v":1E-35,"d":"1.00E-35"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0010951|negative regulation of endopeptidase activity;","GO:0005615|extracellular space;","GO:0004867|serine-type endopeptidase inhibitor activity;","K04525","SERPINA; serpin A"]
["ENSRNOG00000031099",63,4.052817606,29,1.87229393,2.164626793,1.114118309,3.56879E-4,2.32332E-4,"up","yes","Tmprss12","protein_coding","chr7:131433484-131445791:+","gi|564309423|ref|XP_003754410.2|",1561,0,"PREDICTED: transmembrane protease serine 12 [Rattus norvegicus]","gi|672022391|ref|XM_003754362.3|",1294,0,"PREDICTED: Rattus norvegicus transmembrane (C-terminal) protease, serine 12 (Tmprss12), mRNA","Q3V0Q7",525,0,"Transmembrane protease serine 12","VC1649",118,{"v":4e-28,"d":"4.00E-28"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0007339|binding of sperm to zona pellucida;GO:0016485|protein processing;","GO:0001669|acrosomal vesicle;","GO:0004252|serine-type endopeptidase activity;",".","."]
["ENSRNOG00000050067",43,2.766208842,16,1.032989754,2.677866678,1.421084135,0.000360809,0.00023481,"up","yes","ENSRNOG00000050067","protein_coding","chr16:58156236-58166965:-","gi|545487328|ref|XP_533590.3|",843,{"v":1e-104,"d":"1.00E-104"},"PREDICTED: 40S ribosomal protein S9 [Canis lupus familiaris]","gi|672080369|ref|XR_596500.1|",731,0,"PREDICTED: Rattus norvegicus ribosomal protein S9-like (LOC100364509), misc_RNA","P29314",325,{"v":2e-105,"d":"2.00E-105"},"40S ribosomal protein S9","SPBC29A3.12",261,{"v":4e-81,"d":"4.00E-81"},"COG0522","pfam00163","Ribosomal_S4","Ribosomal protein S4/S9 N-terminal domain. This family includes small ribosomal subunit S9 from prokaryotes and S16 from metazoans. This domain is predicted to bind to ribosomal RNA. This domain is composed of four helices in the known structure. However the domain is discontinuous in sequence and the alignment for this family contains only the first three helices.","GO:0006412|translation;",".",".",".","."]
["ENSRNOG00000020873",57,3.666834977,25,1.614046491,2.271827358,1.183853205,0.000363818,0.000236687,"up","yes","Nphs1","protein_coding","chr1:85720812-85749078:+","gi|12018318|ref|NP_072150.1|",5372,0,"nephrin precursor [Rattus norvegicus]","gi|12018317|ref|NM_022628.1|",3538,0,"Rattus norvegicus NPHS1 nephrin (Nphs1), mRNA","Q9R044",2069,0,"Nephrin",".",".",".",".","pfam08205","C2-set_2","CD80-like C2-set immunoglobulin domain. These domains belong to the immunoglobulin superfamily.","GO:0000165|MAPK cascade;GO:0003094|glomerular filtration;GO:0007155|cell adhesion;GO:0007254|JNK cascade;GO:0007519|skeletal muscle tissue development;GO:0007520|myoblast fusion;GO:0030838|positive regulation of actin filament polymerization;GO:0032836|glomerular basement membrane development;GO:0035418|protein localization to synapse;GO:0044062|regulation of excretion;GO:0072015|glomerular visceral epithelial cell development;GO:0098609|cell-cell adhesion;","GO:0005604|basement membrane;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005911|cell-cell junction;GO:0005925|focal adhesion;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0032991|protein-containing complex;GO:0036057|slit diaphragm;GO:0042995|cell projection;GO:0045121|membrane raft;","GO:0005515|protein binding;GO:0017022|myosin binding;GO:0019904|protein domain specific binding;GO:0030507|spectrin binding;GO:0050839|cell adhesion molecule binding;GO:0051393|alpha-actinin binding;","K24496","NPHS1; nephron"]
["ENSRNOG00000013610",31,1.994243584,9,0.581056737,3.432097861,1.77909069,0.00036556,0.00023774,"up","yes","Chrna5","protein_coding","chr8:55369794-55398146:+","gi|158534079|ref|NP_058774.2|",2205,0,"neuronal acetylcholine receptor subunit alpha-5 precursor [Rattus norvegicus]","gi|158534078|ref|NM_017078.2|",3007,0,"Rattus norvegicus cholinergic receptor nicotinic alpha 5 subunit (Chrna5), mRNA","P20420",852,0,"Neuronal acetylcholine receptor subunit alpha-5",".",".",".",".","pfam02931","Neur_chan_LBD","Neurotransmitter-gated ion-channel ligand binding domain. This family is the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.","GO:0007165|signal transduction;GO:0007268|chemical synaptic transmission;GO:0007271|synaptic transmission, cholinergic;GO:0034220|ion transmembrane transport;GO:0035094|response to nicotine;GO:0035095|behavioral response to nicotine;GO:0042391|regulation of membrane potential;GO:0050877|nervous system process;GO:0060079|excitatory postsynaptic potential;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005892|acetylcholine-gated channel complex;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0098691|dopaminergic synapse;","GO:0004888|transmembrane signaling receptor activity;GO:0005230|extracellular ligand-gated ion channel activity;GO:0005515|protein binding;GO:0015464|acetylcholine receptor activity;GO:0022848|acetylcholine-gated cation-selective channel activity;GO:0030594|neurotransmitter receptor activity;GO:0042166|acetylcholine binding;GO:0044877|protein-containing complex binding;","K04807","CHRNA5; nicotinic acetylcholine receptor alpha-5"]
["ENSRNOG00000042533",46,2.959200157,18,1.162113474,2.546395187,1.348456335,0.000392134,0.000254277,"up","yes","Accsl","protein_coding","chr3:79826464-79841163:-","gi|157819169|ref|NP_001103064.1|",3137,0,"probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2 [Rattus norvegicus]","gi|157819168|ref|NM_001109594.1|",2167,0,"Rattus norvegicus 1-aminocyclopropane-1-carboxylate synthase-like (Accsl), mRNA","Q3UX83",906,0,"Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2","TM1255",91.7,{"v":5e-19,"d":"5.00E-19"},"COG0436","pfam00155","Aminotran_1_2","Aminotransferase class I and II.","GO:0006520|cellular amino acid metabolic process;GO:0009058|biosynthetic process;",".","GO:0003824|catalytic activity;GO:0008483|transaminase activity;GO:0030170|pyridoxal phosphate binding;",".","."]
["ENSRNOG00000064150",21,1.350939202,4,0.258247439,5.231181417,2.387136803,0.000396989,0.0002573,"up","yes","ENSRNOG00000064150","lncRNA","chr17:83659433-83682702:+",".",".",".",".","gi|672030333|ref|XR_598232.1|",492,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102550221 (LOC102550221), transcript variant X1, ncRNA",".",".",".",".",".",".",".",".","pfam05875","Ceramidase","Ceramidase. This family consists of several ceramidases. Ceramidases are enzymes involved in regulating cellular levels of ceramides, sphingoid bases, and their phosphates, EC:3.5.1.23.",".",".",".",".","."]
["ENSRNOG00000007375",23,1.479600078,5,0.322809298,4.583511337,2.196453242,0.000422857,0.000273383,"up","yes","Ccdc105","protein_coding","chr7:10902182-10907671:+","gi|71043918|ref|NP_001020945.1|",2553,0,"coiled-coil domain-containing protein 105 [Rattus norvegicus]","gi|71043917|ref|NM_001025774.1|",1697,0,"Rattus norvegicus coiled-coil domain containing 105 (Ccdc105), mRNA",".",".",".",".",".",".",".",".","pfam03148","Tektin","Tektin family. Tektins are cytoskeletal proteins. They have been demonstrated in such cellular sites as centrioles, basal bodies, and along ciliary and flagellar doublet microtubules. Tektins form unique protofilaments, organized as longitudinal polymers of tektin heterodimers with axial periodicity matching tubulin. Tektin polypeptides consist of several alpha-helical regions that are predicted to form coiled coils. Indeed, tektins share considerable structural similarities with intermediate filament proteins. Possible functional roles for tektins are: stabilisation of tubulin protofilaments; attachment of A and B-tubules in ciliary/flagellar microtubule doublets and C-tubules in centrioles; binding of axonemal components.",".",".",".",".","."]
["ENSRNOG00000070797",52,3.345182786,22,1.420360912,2.355163928,1.23582748,0.000427175,0.000276005,"up","yes","ENSRNOG00000070797","lncRNA","chr14:83406164-83425204:-","gi|74212867|dbj|BAE33389.1|",166,{"v":1E-10,"d":"1.00E-10"},"unnamed protein product [Mus musculus]","gi|672028134|ref|XR_594133.1|",609,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102557304 (LOC102557304), transcript variant X1, ncRNA",".",".",".",".",".",".",".",".","pfam13765","PRY","SPRY-associated domain. SPRY and PRY domains occur on PYRIN proteins. Their function is not known.",".",".",".",".","."]
["ENSRNOG00000021381",25,1.608260955,6,0.387371158,4.151731283,2.05371307,0.000427202,0.000276005,"up","yes","Ccdc68","protein_coding","chr18:63541896-63584119:+","gi|149064570|gb|EDM14773.1|",1572,0,"similar to CTCL tumor antigen se57-1 (predicted), isoform CRA_b [Rattus norvegicus]","gi|755561085|ref|XM_006526071.2|",919,0,"PREDICTED: Mus musculus coiled-coil domain containing 68 (Ccdc68), transcript variant X2, mRNA","Q8BVC4",496,{"v":3e-172,"d":"3.00E-172"},"Coiled-coil domain-containing protein 68",".",".",".",".","pfam15619","Lebercilin","Ciliary protein causing Leber congenital amaurosis disease. Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.","GO:0008104|protein localization;GO:0034454|microtubule anchoring at centrosome;GO:0035556|intracellular signal transduction;","GO:0005622|intracellular;GO:0005814|centriole;GO:0120103|centriolar subdistal appendage;",".","K25398","CCDC68; coiled-coil domain containing protein 68"]
["ENSRNOG00000070022",25,1.608260955,6,0.387371158,4.151731283,2.05371307,0.000427202,0.000276005,"up","yes","ENSRNOG00000070022","lncRNA","chr7:17177556-17192039:-","gi|149031650|gb|EDL86613.1|",173,{"v":1e-11,"d":"1.00E-11"},"similar to hypothetical protein 4930509O22 [Rattus norvegicus]","gi|672058333|ref|XM_008765270.1|",3610,0,"PREDICTED: Rattus norvegicus similar to hypothetical protein 4930509O22 (RGD1566251), transcript variant X4, mRNA",".",".",".",".",".",".",".",".","pfam07313","DUF1460","Protein of unknown function (DUF1460). This family consists of several hypothetical bacterial proteins of around 260 residues in length. The function of this family is unknown.",".",".",".",".","."]
["ENSRNOG00000022635",71,4.567461111,35,2.259665088,2.02130003,1.015283483,0.000442373,0.000284904,"up","yes","Dlg2","protein_coding","chr1:144451472-146499475:+","gi|589932495|ref|XP_006979045.1|",4423,0,"PREDICTED: disks large homolog 2-like isoform X2 [Peromyscus maniculatus bairdii]","gi|795347427|ref|XM_012075517.1|",2627,0,"PREDICTED: Cercocebus atys discs, large homolog 2 (Drosophila) (DLG2), transcript variant X14, mRNA","Q15700",1699,0,"Disks large homolog 2","YDR454c",102,{"v":1E-22,"d":"1.00E-22"},"COG0194","pfam00625","Guanylate_kin","Guanylate kinase.","GO:0007268|chemical synaptic transmission;GO:0009790|embryo development;GO:0019233|sensory perception of pain;GO:0035865|cellular response to potassium ion;GO:0043113|receptor clustering;GO:0045161|neuronal ion channel clustering;GO:0045197|establishment or maintenance of epithelial cell apical/basal polarity;GO:0097120|receptor localization to synapse;GO:0098609|cell-cell adhesion;GO:0099562|maintenance of postsynaptic density structure;GO:0099641|anterograde axonal protein transport;GO:0099642|retrograde axonal protein transport;GO:0099645|neurotransmitter receptor localization to postsynaptic specialization membrane;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0016323|basolateral plasma membrane;GO:0030054|cell junction;GO:0030425|dendrite;GO:0030672|synaptic vesicle membrane;GO:0031594|neuromuscular junction;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0044224|juxtaparanode region of axon;GO:0045211|postsynaptic membrane;GO:0098839|postsynaptic density membrane;GO:0098978|glutamatergic synapse;GO:0099031|anchored component of postsynaptic density membrane;GO:1904115|axon cytoplasm;","GO:0005515|protein binding;GO:0008022|protein C-terminus binding;GO:0019900|kinase binding;GO:0019903|protein phosphatase binding;GO:0030165|PDZ domain binding;GO:0044877|protein-containing complex binding;GO:0098919|structural constituent of postsynaptic density;","K12075","DLG2; discs large protein 2"]
["ENSRNOG00000048823",12,0.771965258,0,0.03228093,23.91397219,4.579781881,0.000442871,0.000285096,"up","yes","AABR07007146.1","protein_coding","chr19:28520-37732:-","gi|392334284|ref|XP_001056053.3|",3011,0,"PREDICTED: pyrethroid hydrolase Ces2e [Rattus norvegicus]","gi|672030984|ref|XM_001056053.5|",1968,0,"PREDICTED: Rattus norvegicus similar to carboxylesterase 5 (LOC679368), mRNA","Q8BK48",1053,0,"Pyrethroid hydrolase Ces2e","BS_pnbA",268,{"v":2e-80,"d":"2.00E-80"},"COG2272","pfam00135","COesterase","Carboxylesterase family.",".",".",".",".","."]
["ENSRNOG00000066561",12,0.771965258,0,0.03228093,23.91397219,4.579781881,0.000442871,0.000285096,"up","yes","ENSRNOG00000066561","protein_coding","chr9:2780475-2782261:-","gi|564365534|ref|XP_006243865.1|",1088,{"v":1e-145,"d":"1.00E-145"},"PREDICTED: poly(rC)-binding protein 4 isoform X2 [Rattus norvegicus]","gi|672063078|ref|XM_006243803.2|",397,0,"PREDICTED: Rattus norvegicus poly(rC) binding protein 4 (Pcbp4), transcript variant X2, mRNA","P57724",387,{"v":7e-132,"d":"7.00E-132"},"Poly(rC)-binding protein 4",".",".",".",".","pfam00013","KH_1","KH domain. KH motifs bind RNA in vitro. Autoantibodies to Nova, a KH domain protein, cause paraneoplastic opsoclonus ataxia.",".",".",".",".","."]
["ENSRNOG00000009153",16,1.029287011,2,0.129123719,7.971324064,2.994819381,4.80939E-4,0.000308628,"up","yes","Cidec","protein_coding","chr4:146569289-146582173:-","gi|348605174|ref|NP_001019504.2|",1177,{"v":1E-153,"d":"1.00E-153"},"cell death activator CIDE-3 isoform 1 [Rattus norvegicus]","gi|348605177|ref|NM_001244798.1|",1539,0,"Rattus norvegicus cell death-inducing DFFA-like effector c (Cidec), transcript variant 3, mRNA","Q5XI33",453,{"v":1E-153,"d":"1.00E-153"},"Cell death activator CIDE-3",".",".",".",".","pfam02017","CIDE-N","CIDE-N domain. This domain is found in CAD nuclease, and in ICAD, the inhibitor of CAD nuclease. The two proteins interact through this domain.","GO:0006915|apoptotic process;GO:0034389|lipid droplet organization;GO:0042981|regulation of apoptotic process;GO:0097194|execution phase of apoptosis;","GO:0005634|nucleus;GO:0005783|endoplasmic reticulum;GO:0005811|lipid droplet;GO:0005829|cytosol;",".",".","."]
["ENSRNOG00000011471",47,3.023530595,19,1.226675333,2.464817309,1.301480719,0.000488326,0.000313052,"up","yes","Fgf9","protein_coding","chr15:32210074-32253309:+","gi|74177316|dbj|BAE34566.1|",611,{"v":5e-84,"d":"5.00E-84"},"unnamed protein product [Mus musculus]","gi|755547794|ref|XM_006518554.2|",1348,0,"PREDICTED: Mus musculus fibroblast growth factor 9 (Fgf9), transcript variant X2, mRNA","P36364",240,{"v":9e-71,"d":"9.00E-71"},"Fibroblast growth factor 9",".",".",".",".","pfam00167","FGF","Fibroblast growth factor. Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide range of contexts. They are found in a wide range of organisms, from nematodes to humans. Most share an internal core region of high similarity, conserved residues in which are involved in binding with their receptors. On binding, they cause dimerization of their tyrosine kinase receptors leading to intracellular signalling. There are currently four known tyrosine kinase receptors for fibroblast growth factors. These receptors can each bind several different members of this family. Members of this family have a beta trefoil structure. Most have N-terminal signal peptides and are secreted. A few lack signal sequences but are secreted anyway; still others also lack the signal peptide but are found on the cell surface and within the extracellular matrix. A third group remain intracellular. They have central roles in development, regulating cell proliferation, migration and differentiation. On the other hand, they are important in tissue repair following injury in adult organisms.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001525|angiogenesis;GO:0001649|osteoblast differentiation;GO:0001654|eye development;GO:0001934|positive regulation of protein phosphorylation;GO:0002053|positive regulation of mesenchymal cell proliferation;GO:0002062|chondrocyte differentiation;GO:0006606|protein import into nucleus;GO:0007267|cell-cell signaling;GO:0008284|positive regulation of cell proliferation;GO:0008543|fibroblast growth factor receptor signaling pathway;GO:0008584|male gonad development;GO:0009887|animal organ morphogenesis;GO:0010628|positive regulation of gene expression;GO:0021762|substantia nigra development;GO:0030154|cell differentiation;GO:0030178|negative regulation of Wnt signaling pathway;GO:0030238|male sex determination;GO:0030324|lung development;GO:0030326|embryonic limb morphogenesis;GO:0030334|regulation of cell migration;GO:0030949|positive regulation of vascular endothelial growth factor receptor signaling pathway;GO:0032927|positive regulation of activin receptor signaling pathway;GO:0042472|inner ear morphogenesis;GO:0043410|positive regulation of MAPK cascade;GO:0045880|positive regulation of smoothened signaling pathway;GO:0048505|regulation of timing of cell differentiation;GO:0048566|embryonic digestive tract development;GO:0048706|embryonic skeletal system development;GO:0050679|positive regulation of epithelial cell proliferation;GO:0051781|positive regulation of cell division;GO:0060045|positive regulation of cardiac muscle cell proliferation;GO:0060484|lung-associated mesenchyme development;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:1904707|positive regulation of vascular smooth muscle cell proliferation;GO:1904754|positive regulation of vascular associated smooth muscle cell migration;GO:1905931|negative regulation of vascular smooth muscle cell differentiation involved in phenotypic switching;","GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0005737|cytoplasm;","GO:0005104|fibroblast growth factor receptor binding;GO:0008083|growth factor activity;GO:0008201|heparin binding;","K04358","FGF; fibroblast growth factor"]
["ENSRNOG00000068340",32,2.058574022,10,0.645618597,3.188529626,1.672891286,0.000524547,0.000335069,"up","yes","ENSRNOG00000068340","lncRNA","chr4:117675777-117682519:+","gi|564303945|ref|XP_006225032.1|",494,{"v":2E-55,"d":"2.00E-55"},"PREDICTED: uncharacterized protein LOC102554508 [Rattus norvegicus]","gi|672050314|ref|XR_353419.2|",736,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102554796 (LOC102554796), transcript variant X3, ncRNA",".",".",".",".",".",".",".",".","pfam15499","Peptidase_C98","Ubiquitin-specific peptidase-like, SUMO isopeptidase. Peptidase_C98 is a small family of SUMO - small ubiquitin-related modifier - isopeptidases found in eukaryotes. Reversible attachment of SUMO is an essential protein modification in all eukaryotic cells, The family neither binds nor cleaves ubiquitin, but is a potent SUMO isopeptidase, and the invariant residues required for SUMO binding and cleavage, in UniProtKB:Q5W0Q7, are Cys-236, His-456 and Asp-472, all of which are fully conserved in the family. Member proteins are low-abundance proteins that colocalize with coilin in Cajal bodies. Peptidase_C98 depletion does not affect global sumoylation, but causes striking coilin mis-localisation and impairs cell proliferation, functions that are not dependent on the catalytic activity. Thus, Peptidase_C98 represents a third type of SUMO protease, with essential functions in Cajal body biology.",".",".",".",".","."]
["ENSRNOG00000069367",45,2.894869718,18,1.162113474,2.49103877,1.316747476,0.000575334,0.000365751,"up","yes","ENSRNOG00000069367","lncRNA","chr3:87787183-87806688:-","gi|149041561|gb|EDL95402.1|",188,{"v":3e-14,"d":"3.00E-14"},"rCG57925 [Rattus norvegicus]","gi|672046442|ref|XR_352469.2|",1896,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102548073 (LOC102548073), ncRNA",".",".",".",".",".",".",".",".","pfam06681","DUF1182","Protein of unknown function (DUF1182). This family consists of several hypothetical proteins of around 360 residues in length and seems to be specific to Caenorhabditis elegans. The function of this family is unknown.",".",".",".",".","."]
["ENSRNOG00000012821",13,0.836295696,1,0.06456186,12.9534016,3.695259099,0.000583706,0.000370497,"up","yes","Cnmd","protein_coding","chr15:55041561-55066297:-","gi|117558828|gb|AAI27494.1|",1786,0,"Leukocyte cell derived chemotaxin 1 [Rattus norvegicus]","gi|13540670|ref|NM_030854.1|",1361,0,"Rattus norvegicus leukocyte cell derived chemotaxin 1 (Lect1), mRNA","O70367",691,0,"Leukocyte cell-derived chemotaxin 1",".",".",".",".","pfam04089","BRICHOS","BRICHOS domain. The BRICHOS domain is about 100 amino acids long. It is found in a variety of proteins implicated in dementia, respiratory distress and cancer. Its exact function is unknown; roles that have been proposed for it include (a) in targeting of the protein to the secretory pathway, (b) intramolecular chaperone-like function, and (c) assisting the specialized intracellular protease processing system. This C-terminal domain is embedded in the endoplasmic reticulum lumen, and binds to the N-terminal, transmembrane, SP_C, pfam08999, provided that it is in non-helical conformation. Thus the Brichos domain of proSP-C is a chaperone that induces alpha-helix formation of an aggregation-prone TM region.","GO:0001886|endothelial cell morphogenesis;GO:0001937|negative regulation of endothelial cell proliferation;GO:0016525|negative regulation of angiogenesis;GO:0030948|negative regulation of vascular endothelial growth factor receptor signaling pathway;GO:0051216|cartilage development;","GO:0005576|extracellular region;GO:0012505|endomembrane system;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000013372",13,0.836295696,1,0.06456186,12.9534016,3.695259099,0.000583706,0.000370497,"up","yes","Shisal2b","protein_coding","chr2:36002651-36019123:-","gi|672015373|ref|XP_001072885.2|",720,{"v":7e-93,"d":"7.00E-93"},"PREDICTED: membrane protein FAM159B [Rattus norvegicus]","gi|672015372|ref|XM_001072885.5|",535,0,"PREDICTED: Rattus norvegicus family with sequence similarity 159, member B (Fam159b), mRNA","Q9D1Y9",253,{"v":1E-84,"d":"1.00E-84"},"Protein shisa-like-2B",".",".",".",".","pfam13908","Shisa","Wnt and FGF inhibitory regulator. Shisa is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000015690",13,0.836295696,1,0.06456186,12.9534016,3.695259099,0.000583706,0.000370497,"up","yes","Adad2","protein_coding","chr19:47665309-47669436:+","gi|672085353|ref|XP_008770874.1|",2588,0,"PREDICTED: LOW QUALITY PROTEIN: adenosine deaminase domain-containing protein 2 isoform X2 [Rattus norvegicus]","gi|672085352|ref|XM_008772652.1|",1736,0,"PREDICTED: Rattus norvegicus adenosine deaminase domain containing 2 (Adad2), transcript variant X2, mRNA","Q9D5P4",812,0,"Adenosine deaminase domain-containing protein 2",".",".",".",".","pfam02137","A_deamin","Adenosine-deaminase (editase) domain. Adenosine deaminases acting on RNA (ADARs) can deaminate adenosine to form inosine. In long double-stranded RNA, this process is non-specific; it occurs site-specifically in RNA transcripts. The former is important in defence against viruses, whereas the latter may affect splicing or untranslated regions. They are primarily nuclear proteins, but a longer isoform of ADAR1 is found predominantly in the cytoplasm. ADARs are derived from the Tad1-like tRNA deaminases that are present across eukaryotes. These in turn belong to the nucleotide/nucleic acid deaminase superfamily and are characterized by a distinct insert between the two conserved cysteines that are involved in binding zinc.","GO:0006382|adenosine to inosine editing;GO:0006396|RNA processing;","GO:0005730|nucleolus;GO:0005737|cytoplasm;","GO:0003725|double-stranded RNA binding;GO:0003726|double-stranded RNA adenosine deaminase activity;GO:0008251|tRNA-specific adenosine deaminase activity;",".","."]
["ENSRNOG00000033020",13,0.836295696,1,0.06456186,12.9534016,3.695259099,0.000583706,0.000370497,"up","yes","Lcn1","protein_coding","chr3:9532915-9536577:+","gi|12621114|ref|NP_075234.1|",851,{"v":6e-114,"d":"6.00E-114"},"von Ebner gland protein 1 precursor [Rattus norvegicus]","gi|12621113|ref|NM_022945.1|",534,0,"Rattus norvegicus lipocalin 1 (Lcn1), mRNA","P20289",332,{"v":2e-115,"d":"2.00E-115"},"von Ebner gland protein 1",".",".",".",".","pfam00061","Lipocalin","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.","GO:0001895|retina homeostasis;GO:0050909|sensory perception of taste;","GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0005102|signaling receptor binding;GO:0008270|zinc ion binding;GO:0031404|chloride ion binding;GO:0036094|small molecule binding;","K25351","LCN1; lipocalin-1"]
["ENSRNOG00000066622",13,0.836295696,1,0.06456186,12.9534016,3.695259099,0.000583706,0.000370497,"up","yes","ENSRNOG00000066622","lncRNA","chr7:62784299-62787126:-",".",".",".",".","gi|672021747|ref|XR_601776.1|",302,{"v":2E-155,"d":"2.00E-155"},"PREDICTED: Rattus norvegicus uncharacterized LOC103690358 (LOC103690358), ncRNA",".",".",".",".",".",".",".",".","pfam03188","Cytochrom_B561","Eukaryotic cytochrome b561. Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.",".",".",".",".","."]
["ENSRNOG00000067538",13,0.836295696,1,0.06456186,12.9534016,3.695259099,0.000583706,0.000370497,"up","yes","ENSRNOG00000067538","lncRNA","chr6:14081555-14149061:-","gi|149057382|gb|EDM08705.1|",216,{"v":8e-18,"d":"8.00E-18"},"similar to RIKEN cDNA 3110040N11, isoform CRA_b [Rattus norvegicus]","gi|755489069|ref|XR_883762.1|",82,{"v":1e-32,"d":"1.00E-32"},"PREDICTED: Mus musculus RIKEN cDNA C230072F16 gene (C230072F16Rik), transcript variant X11, ncRNA",".",".",".",".",".",".",".",".","pfam11122","Spore-coat_CotD","Inner spore coat protein D. This family is conserved in the Enterobacteriaceae family. CotD is an inner spore coat protein that is expressed in the middle phase of mother cell gene expression. Along with CotD, CotH, CotS and CotT it is assumed to assemble into the loose skeleton of the matrix, between the shells of SpoIVA and CotE. Coat proteins do not share much sequence similarity between species, but this does not imply they do not share secondary, tertiary, or quaternary features.",".",".",".",".","."]
["ENSRNOG00000010696",48,3.087861033,20,1.291237193,2.391397219,1.257853786,0.000599812,3.80212E-4,"up","yes","Neil2","protein_coding","chr15:37445381-37454863:-","gi|157822593|ref|NP_001100740.1|",1675,0,"endonuclease 8-like 2 [Rattus norvegicus]","gi|157822592|ref|NM_001107270.1|",1042,0,"Rattus norvegicus nei-like DNA glycosylase 2 (Neil2), mRNA","Q6R2P8",583,0,"Endonuclease 8-like 2",".",".",".",".","pfam06831","H2TH","Formamidopyrimidine-DNA glycosylase H2TH domain. Formamidopyrimidine-DNA glycosylase (Fpg) is a DNA repair enzyme that excises oxidized purines from damaged DNA. This family is the central domain containing the DNA-binding helix-two turn-helix domain.","GO:0006284|base-excision repair;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0015630|microtubule cytoskeleton;GO:0043231|intracellular membrane-bounded organelle;GO:0072686|mitotic spindle;","GO:0003684|damaged DNA binding;GO:0003906|DNA-(apurinic or apyrimidinic site) endonuclease activity;GO:0008017|microtubule binding;GO:0008270|zinc ion binding;GO:0019104|DNA N-glycosylase activity;GO:0140078|class I DNA-(apurinic or apyrimidinic site) endonuclease activity;","K10568","NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]"]
["ENSRNOG00000012609",18,1.157947887,3,0.193685579,5.978493048,2.579781881,0.000608903,3.8559E-4,"up","yes","Trdn","protein_coding","chr1:23955651-24410595:-","gi|149032864|gb|EDL87719.1|",1014,{"v":3e-120,"d":"3.00E-120"},"triadin, isoform CRA_d [Rattus norvegicus]","gi|31340608|ref|NM_021666.2|",4147,0,"Rattus norvegicus triadin (Trdn), mRNA","Q9QX75",386,{"v":8E-116,"d":"8.00E-116"},"Triadin",".",".",".",".","pfam05279","Asp-B-Hydro_N","Aspartyl beta-hydroxylase N-terminal region. This family includes the N-terminal regions of the junctin, junctate and aspartyl beta-hydroxylase proteins. Junctate is an integral ER/SR membrane calcium binding protein, which comes from an alternatively spliced form of the same gene that generates aspartyl beta-hydroxylase and junctin. Aspartyl beta-hydroxylase catalyses the post-translational hydroxylation of aspartic acid or asparagine residues contained within epidermal growth factor (EGF) domains of proteins.","GO:0006874|cellular calcium ion homeostasis;GO:0009617|response to bacterium;GO:0010880|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0014070|response to organic cyclic compound;GO:0014808|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0014902|myotube differentiation;GO:0031122|cytoplasmic microtubule organization;GO:0051280|negative regulation of release of sequestered calcium ion into cytosol;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;GO:0060047|heart contraction;GO:0060316|positive regulation of ryanodine-sensitive calcium-release channel activity;GO:0086036|regulation of cardiac muscle cell membrane potential;GO:0090158|endoplasmic reticulum membrane organization;GO:1901846|positive regulation of cell communication by electrical coupling involved in cardiac conduction;","GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0014701|junctional sarcoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0016529|sarcoplasmic reticulum;GO:0030314|junctional membrane complex;GO:0033017|sarcoplasmic reticulum membrane;GO:0034704|calcium channel complex;GO:0042383|sarcolemma;GO:0043231|intracellular membrane-bounded organelle;","GO:0005102|signaling receptor binding;GO:0005515|protein binding;GO:0030674|protein binding, bridging;GO:0044325|ion channel binding;","K23449","TRDN; triadin"]
["ENSRNOG00000049495",18,1.157947887,3,0.193685579,5.978493048,2.579781881,0.000608903,3.8559E-4,"up","yes","Krt71","protein_coding","chr7:132873540-132882325:-","gi|449310818|ref|NP_001263369.1|",2121,0,"keratin 71 [Rattus norvegicus]","gi|672060279|ref|XM_008765783.1|",2154,0,"PREDICTED: Rattus norvegicus keratin 71 (Krt71), transcript variant X1, mRNA","Q9R0H5",810,0,"Keratin, type II cytoskeletal 71",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0031069|hair follicle morphogenesis;GO:0045109|intermediate filament organization;","GO:0045095|keratin filament;",".","K07605","KRT2; type II keratin, basic"]
["ENSRNOG00000070362",18,1.157947887,3,0.193685579,5.978493048,2.579781881,0.000608903,3.8559E-4,"up","yes","Hist1h2bg","protein_coding","chr17:41571210-41571896:+","gi|45768638|gb|AAH67485.1|",491,{"v":3e-59,"d":"3.00E-59"},"HIST1H2BM protein, partial [Homo sapiens]","gi|56345|emb|X59961.1|",619,0,"R.norvegicus genes for H2A and H2B histones","Q93079",188,{"v":6e-59,"d":"6.00E-59"},"Histone H2B type 1-H",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.",".",".",".",".","."]
["ENSRNOG00000068539",51,3.280852347,22,1.420360912,2.309872314,1.207813104,0.000612151,3.87518E-4,"up","yes","ENSRNOG00000068539","lncRNA","chr1:20229465-20235866:-","gi|149062621|gb|EDM13044.1|",131,9e-06,"rCG63645 [Rattus norvegicus]","gi|755481919|ref|XR_392793.2|",577,0,"PREDICTED: Mus musculus predicted gene, 36313 (Gm36313), transcript variant X2, ncRNA",".",".",".",".",".",".",".",".","pfam07999","RHSP","Retrotransposon hot spot protein. Members of this family are retrotransposon hot spot proteins. They are associated with polymorphic subtelomeric regions in Trypanosoma. These proteins contain a P-loop motif.",".",".",".",".","."]
["ENSRNOG00000062945",40,2.573217527,15,0.968427895,2.657108021,1.40985688,0.00062625,0.000396004,"up","yes","ENSRNOG00000062945","pseudogene","chr11:82504956-82505359:-","gi|148665111|gb|EDK97527.1|",293,{"v":4e-31,"d":"4.00E-31"},"mCG126588, isoform CRA_a, partial [Mus musculus]","gi|53734299|gb|BC083922.1|",386,0,"Rattus norvegicus cDNA clone IMAGE:7135213",".",".",".",".",".",".",".",".","pfam12250","AftA_N","Arabinofuranosyltransferase N terminal. This domain family is found in bacteria, and is typically between 430 and 441 amino acids in length. This family is the N terminal region of AftA. The enzyme catalyses the addition of the first key arabinofuranosyl residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol to the galactan domain of the cell wall, thus priming the galactan for further elaboration by the arabinofuranosyltransferases. The N terminal region has been predicted to span 11 transmembrane regions.",".",".",".",".","."]
["ENSRNOG00000025360",28,1.801252269,8,0.516494877,3.487454278,1.802174303,0.000632698,3.99727E-4,"up","yes","Exd1","protein_coding","chr3:106508076-106535922:-","gi|157820709|ref|NP_001101231.1|",2945,0,"exonuclease 3'-5' domain-containing protein 1 [Rattus norvegicus]","gi|157820708|ref|NM_001107761.1|",3435,0,"Rattus norvegicus exonuclease 3'-5' domain containing 1 (Exd1), mRNA","Q8CDF7",992,0,"piRNA biogenesis protein EXD1",".",".",".",".","pfam01612","DNA_pol_A_exo1","3'-5' exonuclease. This domain is responsible for the 3'-5' exonuclease proofreading activity of Escherichia coli DNA polymerase I (polI) and other enzymes, it catalyses the hydrolysis of unpaired or mismatched nucleotides. This domain consists of the amino-terminal half of the Klenow fragment in Escherichia coli polI it is also found in the Werner syndrome helicase (WRN), focus forming activity 1 protein (FFA-1) and ribonuclease D (RNase D). Werner syndrome is a human genetic disorder causing premature aging; the WRN protein has helicase activity in the 3'-5' direction. The FFA-1 protein is required for formation of a replication foci and also has helicase activity; it is a homologue of the WRN protein. RNase D is a 3'-5' exonuclease involved in tRNA processing. Also found in this family is the autoantigen PM/Scl thought to be involved in polymyositis-scleroderma overlap syndrome.","GO:0031047|gene silencing by RNA;GO:0034587|piRNA metabolic process;GO:0090305|nucleic acid phosphodiester bond hydrolysis;","GO:1990923|PET complex;","GO:0003676|nucleic acid binding;GO:0008408|3'-5' exonuclease activity;","K18740","EXD1, EGL; exonuclease 3'-5' domain-containing protein 1"]
["ENSRNOG00000057769",28,1.801252269,8,0.516494877,3.487454278,1.802174303,0.000632698,3.99727E-4,"up","yes","Oas1h","protein_coding","chr12:35683699-35693366:-","gi|57222310|ref|NP_001009491.1|",1932,0,"2 ' -5 ' oligoadenylate synthetase 1H [Rattus norvegicus]","gi|57222309|ref|NM_001009491.1|",1701,0,"Rattus norvegicus 2 ' -5 ' oligoadenylate synthetase 1H (Oas1h), mRNA","Q924S2",455,{"v":7e-155,"d":"7.00E-155"},"Inactive 2'-5' oligoadenylate synthetase 1C",".",".",".",".","pfam10421","OAS1_C","2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus. This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between 320 and 344 at the extreme C-terminal end. Oligoadenylate synthetases are antiviral enzymes that counteract vial attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesize 2'.5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication. This domain is often associated with NTP_transf_2 pfam01909.","GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0051607|defense response to virus;GO:0060700|regulation of ribonuclease activity;","GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0016020|membrane;","GO:0001730|2'-5'-oligoadenylate synthetase activity;GO:0003725|double-stranded RNA binding;",".","."]
["ENSRNOG00000066012",35,2.251565336,12,0.774742316,2.906211898,1.539139897,6.37621E-4,0.00040257,"up","yes","ENSRNOG00000066012","lncRNA","chr19:13736990-13760943:-","gi|672085018|ref|XP_008770774.1|",173,{"v":3E-10,"d":"3.00E-10"},"PREDICTED: uncharacterized protein LOC363324 isoform X5 [Rattus norvegicus]","gi|425703057|gb|AC246664.5|",1798,0,"Rattus norvegicus Y Chr BAC RNAEX-360A21 (Amplicon Express Rat SHR-Akr BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam02994","Transposase_22","L1 transposable element.",".",".",".",".","."]
["ENSRNOG00000039473",43,2.766208842,17,1.097551614,2.520345108,1.333621294,6.76871E-4,0.000426315,"up","yes","Ccdc152","protein_coding","chr2:52507981-52532826:-","gi|300794723|ref|NP_001178888.1|",1221,{"v":1e-164,"d":"1.00E-164"},"coiled-coil domain-containing protein 152 [Rattus norvegicus]","gi|672041608|ref|XM_006231988.2|",1320,0,"PREDICTED: Rattus norvegicus coiled-coil domain containing 152 (Ccdc152), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam02463","SMC_N","RecF/RecN/SMC N terminal domain. This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics.   This family also includes the RecF and RecN proteins that are involved in DNA metabolizm and recombination.",".",".",".",".","."]
["ENSRNOG00000065746",61,3.924156729,29,1.87229393,2.095908482,1.067575723,0.00069017,0.000434355,"up","yes","ENSRNOG00000065746","protein_coding","chr19:22863313-23006750:-","gi|564321260|ref|XP_006222749.1|",710,{"v":2e-86,"d":"2.00E-86"},"PREDICTED: uncharacterized protein RGD1562660 isoform X2 [Rattus norvegicus]","gi|672034008|ref|XM_008758657.1|",710,0,"PREDICTED: Rattus norvegicus similar to RIKEN cDNA 5031410I06 (LOC679711), transcript variant X4, mRNA",".",".",".",".",".",".",".",".","pfam04822","Takusan","Takusan. This domain is named takusan, which is a Japanese word meaning 'many'. Members of this family regulate synaptic activity.",".",".",".",".","."]
["ENSRNOG00000011705",24,1.543930516,6,0.387371158,3.985662032,1.994819381,0.000706815,0.000444341,"up","yes","Stmn2","protein_coding","chr2:93204692-93252011:-","gi|16758184|ref|NP_445892.1|",880,{"v":2e-111,"d":"2.00E-111"},"stathmin-2 [Rattus norvegicus]","gi|56799413|ref|NM_053440.2|",1802,0,"Rattus norvegicus stathmin 2 (Stmn2), mRNA","P21818",343,{"v":6e-113,"d":"6.00E-113"},"Stathmin-2",".",".",".",".","pfam00836","Stathmin","Stathmin family. The Stathmin family of proteins play an important role in the regulation of the microtubule cytoskeleton. They regulate microtubule dynamics by promoting depolymerization of microtubules and/or preventing polymerization of tubulin heterodimers.","GO:0007019|microtubule depolymerization;GO:0007026|negative regulation of microtubule depolymerization;GO:0010976|positive regulation of neuron projection development;GO:0010977|negative regulation of neuron projection development;GO:0031110|regulation of microtubule polymerization or depolymerization;GO:0031115|negative regulation of microtubule polymerization;GO:0031117|positive regulation of microtubule depolymerization;GO:0031175|neuron projection development;GO:1990090|cellular response to nerve growth factor stimulus;","GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005794|Golgi apparatus;GO:0016020|membrane;GO:0030027|lamellipodium;GO:0030426|growth cone;GO:0031982|vesicle;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0048471|perinuclear region of cytoplasm;","GO:0005515|protein binding;GO:0015631|tubulin binding;GO:0048306|calcium-dependent protein binding;",".","."]
["ENSRNOG00000021657",24,1.543930516,6,0.387371158,3.985662032,1.994819381,0.000706815,0.000444341,"up","yes","Pld6","protein_coding","chr10:44577675-44581077:-","gi|27671958|ref|XP_220517.1|",864,{"v":3e-110,"d":"3.00E-110"},"PREDICTED: mitochondrial cardiolipin hydrolase isoform X1 [Rattus norvegicus]","gi|672024824|ref|XM_001077240.5|",1354,0,"PREDICTED: Rattus norvegicus phospholipase D family, member 6 (Pld6), transcript variant X1, mRNA","Q5SWZ9",326,{"v":2E-107,"d":"2.00E-107"},"Mitochondrial cardiolipin hydrolase","PA3727",97.1,{"v":7e-22,"d":"7.00E-22"},"COG1502","pfam13091","PLDc_2","PLD-like domain.","GO:0007286|spermatid development;GO:0008053|mitochondrial fusion;GO:0008150|biological_process;GO:0010636|positive regulation of mitochondrial fusion;GO:0016042|lipid catabolic process;GO:0030719|P granule organization;GO:0034587|piRNA metabolic process;GO:0043046|DNA methylation involved in gamete generation;GO:0051321|meiotic cell cycle;","GO:0005575|cellular_component;GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;","GO:0003674|molecular_function;GO:0016891|endoribonuclease activity, producing 5'-phosphomonoesters;GO:0035755|cardiolipin hydrolase activity;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;","K16862","PLD6; mitochondrial cardiolipin hydrolase [EC:3.1.4.-]"]
["ENSRNOG00000013781",55,3.5381741,25,1.614046491,2.192114118,1.132322904,0.000726078,4.55799E-4,"up","yes","Kcnq5","protein_coding","chr9:23833087-24394704:-","gi|403225003|ref|NP_001128115.2|",4645,0,"potassium voltage-gated channel subfamily KQT member 5 [Rattus norvegicus]","gi|403225002|ref|NM_001134643.2|",3631,0,"Rattus norvegicus potassium voltage-gated channel subfamily Q member 5 (Kcnq5), mRNA","Q9JK45",1702,0,"Potassium voltage-gated channel subfamily KQT member 5","all4633",83.2,{"v":2E-16,"d":"2.00E-16"},"COG1226","pfam03520","KCNQ_channel","KCNQ voltage-gated potassium channel. This family matches to the C-terminal tail of KCNQ type potassium channels.","GO:0006813|potassium ion transport;GO:0034765|regulation of ion transmembrane transport;GO:0071805|potassium ion transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0008076|voltage-gated potassium channel complex;GO:0016021|integral component of membrane;GO:0030118|clathrin coat;","GO:0005249|voltage-gated potassium channel activity;GO:0005251|delayed rectifier potassium channel activity;GO:0005516|calmodulin binding;","K04930","KCNQ5, KV7.5; potassium voltage-gated channel KQT-like subfamily member 5"]
["ENSRNOG00000064728",55,3.5381741,25,1.614046491,2.192114118,1.132322904,0.000726078,4.55799E-4,"up","yes","ENSRNOG00000064728","lncRNA","chr7:52119551-52120658:+","gi|12855414|dbj|BAB30329.1|",153,2E-8,"unnamed protein product [Mus musculus]","gi|259089668|gb|AC136025.3|",1104,0,"Rattus norvegicus CH230-236M3 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam05956","APC_basic","APC basic domain. This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.",".",".",".",".","."]
["ENSRNOG00000070092",52,3.345182786,23,1.484922772,2.252765496,1.171697143,0.000732222,0.000459403,"up","yes","Dnah14","protein_coding","chr13:93322711-93538646:+","gi|672027563|ref|XP_008762213.1|",24012,0,"PREDICTED: dynein heavy chain 14, axonemal isoform X1 [Rattus norvegicus]","gi|755496242|ref|XM_011238901.1|",8621,0,"PREDICTED: Mus musculus dynein, axonemal, heavy chain 14 (Dnah14), transcript variant X6, mRNA","Q9C0G6",2227,0,"Dynein heavy chain 6, axonemal","YKR054c",315,{"v":2e-84,"d":"2.00E-84"},"COG5245","pfam03028","Dynein_heavy","Dynein heavy chain and region D6 of dynein motor. This family represents the C-terminal region of dynein heavy chain. The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained.",".",".",".",".","."]
["ENSRNOG00000002126",41,2.637547966,16,1.032989754,2.553314739,1.352371385,0.000794968,0.000496914,"up","yes","Ncam2","protein_coding","chr11:20104925-20591984:+","gi|42821116|ref|NP_981954.1|",3844,0,"neural cell adhesion molecule 2 precursor [Rattus norvegicus]","gi|42821115|ref|NM_203409.1|",4078,0,"Rattus norvegicus neural cell adhesion molecule 2 (Ncam2), mRNA","O35136",1479,0,"Neural cell adhesion molecule 2",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0007155|cell adhesion;GO:0007413|axonal fasciculation;GO:0007608|sensory perception of smell;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016604|nuclear body;GO:0030424|axon;GO:0043005|neuron projection;","GO:0042802|identical protein binding;","K06491","NCAM, CD56; neural cell adhesion molecule"]
["ENSRNOG00000038738",41,2.637547966,16,1.032989754,2.553314739,1.352371385,0.000794968,0.000496914,"up","yes","ENSRNOG00000038738","protein_coding","chr9:48568409-48584831:+","gi|564311549|ref|XP_006226886.1|",482,{"v":2e-57,"d":"2.00E-57"},"PREDICTED: small membrane A-kinase anchor protein [Rattus norvegicus]","gi|672065301|ref|XM_008767147.1|",894,0,"PREDICTED: Rattus norvegicus hypothetical protein LOC685203 (LOC685203), transcript variant X5, mRNA","Q9CPS8",162,{"v":4e-48,"d":"4.00E-48"},"Small membrane A-kinase anchor protein",".",".",".",".","pfam15127","DUF4565","Protein of unknown function (DUF4565). This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. This family includes the human protein C2orf88.",".","GO:0005886|plasma membrane;","GO:0034237|protein kinase A regulatory subunit binding;",".","."]
["ENSRNOG00000031065",11,0.70763482,0,0.03228093,21.92114118,4.454250999,0.000827864,0.000515615,"up","yes","RT1-M1-2","protein_coding","chr20:1910656-1917936:-","gi|57012410|ref|NP_001008849.1|",1659,0,"RT1 class I, locus M1, gene 2 precursor [Rattus norvegicus]","gi|672085546|ref|XM_006255884.2|",1448,0,"PREDICTED: Rattus norvegicus RT1 class I, locus M1, gene 2 (RT1-M1-2), transcript variant X1, mRNA","P30375",331,{"v":1e-106,"d":"1.00E-106"},"Class I histocompatibility antigen, Gogo-A*0101 alpha chain",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.",".",".",".","K06751","MHC1; MHC class I antigen"]
["ENSRNOG00000057750",11,0.70763482,0,0.03228093,21.92114118,4.454250999,0.000827864,0.000515615,"up","yes","AABR07018058.1","protein_coding","chr15:31592001-31592384:-","gi|731501926|ref|XP_003417074.2|",638,{"v":6e-83,"d":"6.00E-83"},"PREDICTED: nuclear transport factor 2 isoform X1 [Loxodonta africana]","gi|672084785|ref|XM_006255480.2|",336,{"v":2E-174,"d":"2.00E-174"},"PREDICTED: Rattus norvegicus nuclear transport factor 2 (Nutf2), transcript variant X1, mRNA","P61972",249,{"v":3e-84,"d":"3.00E-84"},"Nuclear transport factor 2",".",".",".",".","pfam02136","NTF2","Nuclear transport factor 2 (NTF2) domain. This family includes the NTF2-like Delta-5-3-ketosteroid isomerase proteins.",".",".",".",".","."]
["ENSRNOG00000062998",11,0.70763482,0,0.03228093,21.92114118,4.454250999,0.000827864,0.000515615,"up","yes","Lcn15l1","protein_coding","chr3:8615948-8620216:+","gi|507539821|ref|XP_004653918.1|",672,{"v":2E-85,"d":"2.00E-85"},"PREDICTED: salivary lipocalin-like [Jaculus jaculus]","gi|880953661|ref|XM_013123260.1|",178,{"v":2e-86,"d":"2.00E-86"},"PREDICTED: Mesocricetus auratus epididymal-specific lipocalin-9-like (LOC101842827), mRNA","Q6UWW0",52.8,2e-07,"Lipocalin-15",".",".",".",".","pfam00061","Lipocalin","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.",".",".",".",".","."]
["ENSRNOG00000064787",44,2.83053928,18,1.162113474,2.435682353,1.284325998,0.000839611,0.000522419,"up","yes","ENSRNOG00000064787","protein_coding","chr2:148724348-148725132:+","gi|149045010|gb|EDL98096.1|",729,{"v":1e-95,"d":"1.00E-95"},"rCG44018, isoform CRA_b [Rattus norvegicus]","gi|672028988|ref|XM_003752855.3|",254,{"v":8e-129,"d":"8.00E-129"},"PREDICTED: Rattus norvegicus spindlin-1-like (LOC100363675), transcript variant X1, mRNA","Q61142",181,{"v":1e-55,"d":"1.00E-55"},"Spindlin-1",".",".",".",".","pfam02513","Spin-Ssty","Spin/Ssty Family. Spindlin (Spin) is a novel maternal transcript present in the unfertilised egg and early embryo. The Y-linked spermiogenesis -specific transcript (Ssty) is also expressed during gametogenesis and forms part of this Pfam family. Members of this family contain three copies of this 50 residue repeat. The repeat is predicted to contain four beta strands.",".",".",".",".","."]
["ENSRNOG00000019404",56,3.602504538,26,1.678608351,2.14612571,1.101734585,0.000851045,0.000529302,"up","yes","Hhatl","protein_coding","chr8:121447002-121454001:-","gi|157822045|ref|NP_001100338.1|",2570,0,"protein-cysteine N-palmitoyltransferase HHAT-like protein [Rattus norvegicus]","gi|157822044|ref|NM_001106868.1|",1626,0,"Rattus norvegicus hedgehog acyltransferase-like (Hhatl), mRNA","Q9D1G3",974,0,"Protein-cysteine N-palmitoyltransferase HHAT-like protein","YGL084c",67.4,{"v":6E-11,"d":"6.00E-11"},"COG1696","pfam03062","MBOAT","MBOAT, membrane-bound O-acyltransferase family. The MBOAT (membrane bound O-acyl transferase) family of membrane proteins contains a variety of acyltransferase enzymes. A conserved histidine has been suggested to be the active site residue.","GO:0060262|negative regulation of N-terminal protein palmitoylation;","GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;GO:0048471|perinuclear region of cytoplasm;","GO:0016746|transferase activity, transferring acyl groups;","K24679","HHATL; protein-cysteine N-palmitoyltransferase HHAT-like protein"]
["ENSRNOG00000027309",50,3.216521909,22,1.420360912,2.2645807,1.179243952,0.000872801,0.000542242,"up","yes","AABR07026805.1","protein_coding","chr17:267508-454102:+","gi|124487467|ref|NP_001074598.1|",5910,0,"contactin-associated protein-like 3 precursor [Mus musculus]","gi|672029647|ref|XR_146664.3|",4439,0,"PREDICTED: Rattus norvegicus similar to Contactin associated protein-like 3 precursor (Cell recognition molecule Caspr3) (RGD1563615), transcript variant X1, misc_RNA","Q9BZ76",1841,0,"Contactin-associated protein-like 3",".",".",".",".","pfam00754","F5_F8_type_C","F5/8 type C domain. This domain is also known as the discoidin (DS) domain family.",".",".",".",".","."]
["ENSRNOG00000012719",15,0.964956573,2,0.129123719,7.47311631,2.901709976,0.000873231,5.42451E-4,"up","yes","Tdrd12","protein_coding","chr1:88133373-88205705:-","gi|672013426|ref|XP_008772725.1|",4403,0,"PREDICTED: putative ATP-dependent RNA helicase TDRD12 [Rattus norvegicus]","gi|672013425|ref|XM_008774503.1|",4553,0,"PREDICTED: Rattus norvegicus tudor domain containing 12 (Tdrd12), mRNA","Q587J7",1181,0,"Putative ATP-dependent RNA helicase TDRD12","ECU08g1080",67.8,{"v":3E-10,"d":"3.00E-10"},"COG0513","pfam00567","TUDOR","Tudor domain.","GO:0007140|male meiotic nuclear division;GO:0007283|spermatogenesis;GO:0008150|biological_process;GO:0009566|fertilization;GO:0030154|cell differentiation;GO:0031047|gene silencing by RNA;GO:0034587|piRNA metabolic process;GO:0043046|DNA methylation involved in gamete generation;","GO:0005575|cellular_component;GO:1990923|PET complex;","GO:0003674|molecular_function;GO:0003676|nucleic acid binding;GO:0005524|ATP binding;","K18409","TDRD12; ATP-dependent RNA helicase TDRD12 [EC:3.6.4.13]"]
["ENSRNOG00000018143",29,1.865582707,9,0.581056737,3.210672192,1.682875374,0.000915441,0.000567253,"up","yes","Hpdl","protein_coding","chr5:130286631-130288233:-","gi|62078869|ref|NP_001014090.1|",1895,0,"4-hydroxyphenylpyruvate dioxygenase-like protein [Rattus norvegicus]","gi|62078868|ref|NM_001014068.1|",1600,0,"Rattus norvegicus 4-hydroxyphenylpyruvate dioxygenase-like (Hpdl), mRNA","Q5XIH9",731,0,"4-hydroxyphenylpyruvate dioxygenase-like protein","all0771",106,{"v":2e-24,"d":"2.00E-24"},"COG3185","pfam12681","Glyoxalase_2","Glyoxalase-like domain. This domain is related to the Glyoxalase domain pfam00903.","GO:0009072|aromatic amino acid family metabolic process;","GO:0005739|mitochondrion;","GO:0003868|4-hydroxyphenylpyruvate dioxygenase activity;GO:0046872|metal ion binding;","K24788","HPDL; 4-hydroxyphenylpyruvate dioxygenase-like protein [EC:1.13.-.-]"]
["ENSRNOG00000063922",39,2.508887089,15,0.968427895,2.590680321,1.373331004,0.000931758,0.000577113,"up","yes","ENSRNOG00000063922","lncRNA","chr7:7287515-7327827:+","gi|672021339|ref|XP_008774590.1|",303,{"v":3E-28,"d":"3.00E-28"},"PREDICTED: zinc finger protein 57 isoform X4 [Rattus norvegicus]","gi|672021438|ref|XM_008776395.1|",1390,0,"PREDICTED: Rattus norvegicus zinc finger protein 709-like (LOC102550588), transcript variant X1, mRNA","P31623",62,{"v":2e-17,"d":"2.00E-17"},"Gag-Pro-Pol polyprotein",".",".",".",".","pfam00607","Gag_p24","gag gene protein p24 (core nucleocapsid protein). p24 forms inner protein layer of the nucleocapsid. ELISA tests for p24 is the most commonly used method to demonstrate virus replication both in vivo and in vitro.",".",".",".",".","."]
["ENSRNOG00000056537",34,2.187234898,12,0.774742316,2.823177273,1.497319721,0.000972708,0.000601237,"up","yes","AABR07021863.1","protein_coding","chr13:89819244-89950979:+","gi|149040837|gb|EDL94794.1|",3037,0,"rCG20269, partial [Rattus norvegicus]","gi|672027436|ref|XM_008763683.1|",1839,0,"PREDICTED: Rattus norvegicus similar to hypothetical protein MGC33370 (RGD1565309), transcript variant X6, mRNA","P0DP43",1030,0,"Cation channel sperm-associated protein subunit epsilon",".",".",".",".","pfam15020","CATSPERD","Cation channel sperm-associated protein subunit delta. The CATSPER (cation channel of sperm) complex is a tetrameric complex consisting of CATSPER1, CATSPER2, CATSPER3 and CATSPER4, it functions as an alkalinisation-activated calcium channel. This complex requires several auxiliary subunits, including CATSPERD. CATSPERD is essential for the cation channel function and may play a role in channel assembly or transport.",".",".",".",".","."]
["ENSRNOG00000052802",57,3.666834977,27,1.743170211,2.10354385,1.072821893,0.000989724,0.000611623,"up","yes","Aldoa","protein_coding","chr1:181402275-181406182:-","gi|564330881|ref|XP_006230271.1|",2133,0,"PREDICTED: fructose-bisphosphate aldolase A isoform X2 [Rattus norvegicus]","gi|672038361|ref|XM_006230210.2|",1545,0,"PREDICTED: Rattus norvegicus aldolase A, fructose-bisphosphate (Aldoa), transcript variant X1, mRNA","P05065",715,0,"Fructose-bisphosphate aldolase A","AGl2190",323,{"v":8e-105,"d":"8.00E-105"},"COG3588","pfam00274","Glycolytic","Fructose-bisphosphate aldolase class-I.","GO:0001666|response to hypoxia;GO:0006000|fructose metabolic process;GO:0006096|glycolytic process;GO:0006754|ATP biosynthetic process;GO:0006941|striated muscle contraction;GO:0007339|binding of sperm to zona pellucida;GO:0008360|regulation of cell shape;GO:0009408|response to heat;GO:0019242|methylglyoxal biosynthetic process;GO:0030335|positive regulation of cell migration;GO:0030388|fructose 1,6-bisphosphate metabolic process;GO:0032496|response to lipopolysaccharide;GO:0035094|response to nicotine;GO:0043627|response to estrogen;GO:0046716|muscle cell cellular homeostasis;GO:0051289|protein homotetramerization;","GO:0000792|heterochromatin;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0015629|actin cytoskeleton;GO:0016020|membrane;GO:0030018|Z disc;GO:0031430|M band;GO:0032991|protein-containing complex;GO:0035686|sperm fibrous sheath;GO:0061827|sperm head;GO:0070062|extracellular exosome;","GO:0002020|protease binding;GO:0003674|molecular_function;GO:0004332|fructose-bisphosphate aldolase activity;GO:0005515|protein binding;GO:0008092|cytoskeletal protein binding;GO:0042802|identical protein binding;GO:0070061|fructose binding;","K01623","ALDO; fructose-bisphosphate aldolase, class I [EC:4.1.2.13]"]
["ENSRNOG00000042404",42,2.701878404,17,1.097551614,2.461732431,1.299673962,0.000991822,0.000612787,"up","yes","Ccdc122","protein_coding","chr15:52407717-52470163:+","gi|672028747|ref|XP_008768280.1|",1518,0,"PREDICTED: coiled-coil domain-containing protein 122 [Rattus norvegicus]","gi|672078865|ref|XM_008770913.1|",1702,0,"PREDICTED: Rattus norvegicus coiled-coil domain containing 122 (Ccdc122), mRNA",".",".",".",".",".",".",".",".","pfam05483","SCP-1","Synaptonemal complex protein 1 (SCP-1). Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.",".",".",".",".","."]
["ENSRNOG00000007084",27,1.736921831,8,0.516494877,3.362902339,1.749706883,1.01016E-3,0.000623645,"up","yes","Marchf10","protein_coding","chr10:90332784-90421588:-","gi|62078675|ref|NP_001013995.1|",3716,0,"probable E3 ubiquitin-protein ligase MARCH10 [Rattus norvegicus]","gi|62078674|ref|NM_001013973.1|",2979,0,"Rattus norvegicus membrane associated ring-CH-type finger 10 (March10), mRNA","Q5XIV2",1436,0,"Probable E3 ubiquitin-protein ligase MARCH10","SPBC14F5.07",56.6,4e-07,"COG5183","pfam12906","RINGv","RING-variant domain.","GO:0016567|protein ubiquitination;",".","GO:0008270|zinc ion binding;GO:0016740|transferase activity;GO:0016874|ligase activity;","K10665","MARCH10; E3 ubiquitin-protein ligase MARCH10 [EC:2.3.2.27]"]
["ENSRNOG00000007266",27,1.736921831,8,0.516494877,3.362902339,1.749706883,1.01016E-3,0.000623645,"up","yes","RGD1311251","protein_coding","chr8:53796366-53824748:+","gi|564363724|ref|XP_006243138.1|",1816,0,"PREDICTED: uncharacterized protein C11orf65 homolog isoform X2 [Rattus norvegicus]","gi|672062002|ref|XM_006243076.2|",1370,0,"PREDICTED: Rattus norvegicus similar to RIKEN cDNA 4930550C14 (RGD1311251), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam03155","Alg6_Alg8","ALG6, ALG8 glycosyltransferase family. N-linked (asparagine-linked) glycosylation of proteins is mediated by a highly conserved pathway in eukaryotes, in which a lipid (dolichol phosphate)-linked oligosaccharide is assembled at the endoplasmic reticulum membrane prior to the transfer of the oligosaccharide moiety to the target asparagine residues. This oligosaccharide is composed of Glc(3)Man(9)GlcNAc(2). The addition of the three glucose residues is the final series of steps in the synthesis of the oligosaccharide precursor. Alg6 transfers the first glucose residue, and Alg8 transfers the second one. In the human alg6 gene, a C->T transition, which causes Ala333 to be replaced with Val, has been identified as the cause of a congenital disorder of glycosylation, designated as type Ic OMIM:603147.","GO:0090258|negative regulation of mitochondrial fission;GO:1903215|negative regulation of protein targeting to mitochondrion;","GO:0005741|mitochondrial outer membrane;GO:0005829|cytosol;",".",".","."]
["ENSRNOG00000068241",54,3.473843662,25,1.614046491,2.152257497,1.105850693,1.018295E-3,0.000628395,"up","yes","ENSRNOG00000068241","protein_coding","chr7:7759282-7780082:-","gi|251823941|ref|NP_001156535.1|",1659,0,"zinc finger protein 878 [Rattus norvegicus]","gi|672057921|ref|XM_008765141.1|",1164,0,"PREDICTED: Rattus norvegicus zinc finger protein 709-like (LOC100909526), transcript variant X2, mRNA","E9QAG8",407,{"v":2e-127,"d":"2.00E-127"},"Zinc finger protein 431",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000033010",51,3.280852347,23,1.484922772,2.209443083,1.143682767,0.001036196,0.000637994,"up","yes","Akr1c12","protein_coding","chr17:66045378-66108329:-","gi|148230802|ref|NP_001014262.3|",1726,0,"aldo-keto reductase family 1, member C13 [Rattus norvegicus]","gi|33187770|gb|AY327508.1|",1221,0,"Rattus norvegicus liver regeneration-related protein LRRG07 mRNA, complete cds","Q8VC28",598,0,"Aldo-keto reductase family 1 member C13","YOR120w",194,{"v":1e-55,"d":"1.00E-55"},"COG0656","pfam00248","Aldo_ket_red","Aldo/keto reductase family. This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.","GO:0008202|steroid metabolic process;","GO:0005829|cytosol;","GO:0004032|alditol:NADP+ 1-oxidoreductase activity;GO:0016229|steroid dehydrogenase activity;GO:0047086|ketosteroid monooxygenase activity;GO:0047834|D-threo-aldose 1-dehydrogenase activity;",".","."]
["ENSRNOG00000046740",48,3.087861033,21,1.355799053,2.277521161,1.187464459,0.001040208,0.000640119,"up","yes","ENSRNOG00000046740","protein_coding","chr6:76623866-76625392:+","gi|795321963|ref|XP_011725748.1|",1765,0,"PREDICTED: eukaryotic initiation factor 4A-I isoform X1 [Macaca nemestrina]","gi|672056186|ref|XR_146036.3|",906,0,"PREDICTED: Rattus norvegicus similar to eukaryotic translation initiation factor 4A, isoform 1 (LOC688672), misc_RNA","P60843",680,0,"Eukaryotic initiation factor 4A-I","SPAC1006.07",487,{"v":9e-171,"d":"9.00E-171"},"COG0513","pfam00270","DEAD","DEAD/DEAH box helicase. Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolizm, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.",".",".",".",".","."]
["ENSRNOG00000064936",48,3.087861033,21,1.355799053,2.277521161,1.187464459,0.001040208,0.000640119,"up","yes","ENSRNOG00000064936","lncRNA","chr8:103583889-103588475:-",".",".",".",".","gi|672063251|ref|XR_594108.1|",2642,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102549824 (LOC102549824), transcript variant X1, ncRNA",".",".",".",".",".",".",".",".","pfam05539","Pneumo_att_G","Pneumovirinae attachment membrane glycoprotein G.",".",".",".",".","."]
["ENSRNOG00000002164",17,1.093617449,3,0.193685579,5.646354545,2.497319721,0.001071763,0.000657978,"up","yes","Nmu","protein_coding","chr14:31844728-31872192:+","gi|149035201|gb|EDL89905.1|",559,{"v":5e-68,"d":"5.00E-68"},"neuromedin U, isoform CRA_c [Rattus norvegicus]","gi|148747286|ref|NM_022239.2|",554,0,"Rattus norvegicus neuromedin U (Nmu), mRNA","P12760",208,{"v":1e-64,"d":"1.00E-64"},"Neuromedin-U",".",".",".",".","pfam02070","NMU","Neuromedin U.","GO:0001659|temperature homeostasis;GO:0001696|gastric acid secretion;GO:0003084|positive regulation of systemic arterial blood pressure;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007218|neuropeptide signaling pathway;GO:0009648|photoperiodism;GO:0010460|positive regulation of heart rate;GO:0019233|sensory perception of pain;GO:0031652|positive regulation of heat generation;GO:0042755|eating behavior;GO:0045187|regulation of circadian sleep/wake cycle, sleep;GO:0045987|positive regulation of smooth muscle contraction;GO:0046887|positive regulation of hormone secretion;GO:0050806|positive regulation of synaptic transmission;GO:0060259|regulation of feeding behavior;GO:0060455|negative regulation of gastric acid secretion;GO:0097009|energy homeostasis;GO:0120061|negative regulation of gastric emptying;GO:0120069|positive regulation of stomach fundus smooth muscle contraction;GO:1902722|positive regulation of prolactin secretion;GO:1903999|negative regulation of eating behavior;GO:1904058|positive regulation of sensory perception of pain;GO:2000252|negative regulation of feeding behavior;GO:2000821|regulation of grooming behavior;","GO:0005576|extracellular region;GO:0043195|terminal bouton;","GO:0031839|type 1 neuromedin U receptor binding;GO:0031840|type 2 neuromedin U receptor binding;GO:0042922|neuromedin U receptor binding;","K05249","NMU; neuromedin U"]
["ENSRNOG00000007395",17,1.093617449,3,0.193685579,5.646354545,2.497319721,0.001071763,0.000657978,"up","yes","Baat","protein_coding","chr5:63850705-63860685:-","gi|148747510|ref|NP_058996.2|",2145,0,"bile acid-CoA:amino acid N-acyltransferase [Rattus norvegicus]","gi|298901365|emb|FQ218773.1|",2705,0,"Rattus norvegicus TL0ABA4YD13 mRNA sequence","Q63276",830,0,"Bile acid-CoA:amino acid N-acyltransferase","CAC3407",130,{"v":4e-31,"d":"4.00E-31"},"COG1073","pfam08840","BAAT_C","BAAT / Acyl-CoA thioester hydrolase C terminal. This catalytic domain is found at the C terminal of acyl-CoA thioester hydrolases and bile acid-CoA:amino acid N-acetyltransferases (BAAT).","GO:0001889|liver development;GO:0002152|bile acid conjugation;GO:0006544|glycine metabolic process;GO:0006631|fatty acid metabolic process;GO:0006637|acyl-CoA metabolic process;GO:0006699|bile acid biosynthetic process;GO:0008206|bile acid metabolic process;GO:0019530|taurine metabolic process;GO:0031100|animal organ regeneration;","GO:0005777|peroxisome;GO:0005829|cytosol;","GO:0003674|molecular_function;GO:0016290|palmitoyl-CoA hydrolase activity;GO:0016410|N-acyltransferase activity;GO:0033882|choloyl-CoA hydrolase activity;GO:0047617|acyl-CoA hydrolase activity;GO:0047963|glycine N-choloyltransferase activity;GO:0052689|carboxylic ester hydrolase activity;GO:0052815|medium-chain acyl-CoA hydrolase activity;GO:0052816|long-chain acyl-CoA hydrolase activity;GO:0052817|very long chain acyl-CoA hydrolase activity;GO:0102991|myristoyl-CoA hydrolase activity;","K00659","BAAT; bile acid-CoA:amino acid N-acyltransferase [EC:2.3.1.65 3.1.2.2]"]
["ENSRNOG00000050602",17,1.093617449,3,0.193685579,5.646354545,2.497319721,0.001071763,0.000657978,"up","yes","Kif28p","protein_coding","chr13:91427736-91482237:-","gi|393393850|ref|NP_001257314.1|",5134,0,"kinesin-like protein KIF28P [Rattus norvegicus]","gi|393393849|ref|NM_001270385.1|",3105,0,"Rattus norvegicus kinesin family member 28, pseudogene (Kif28p), mRNA","F8WLE0",1982,0,"Kinesin-like protein KIF28P","SPAC1834.07",211,{"v":2e-57,"d":"2.00E-57"},"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0007005|mitochondrion organization;GO:0007018|microtubule-based movement;GO:0072384|organelle transport along microtubule;","GO:0005871|kinesin complex;GO:0005874|microtubule;GO:0031966|mitochondrial membrane;","GO:0003777|microtubule motor activity;GO:0005524|ATP binding;GO:0008017|microtubule binding;GO:0016887|ATPase activity;",".","."]
["ENSRNOG00000063038",17,1.093617449,3,0.193685579,5.646354545,2.497319721,0.001071763,0.000657978,"up","yes","ENSRNOG00000063038","protein_coding","chr17:54151623-54154198:+","gi|564319956|ref|XP_001057382.3|",1276,{"v":1E-173,"d":"1.00E-173"},"PREDICTED: ral guanine nucleotide dissociation stimulator-like [Rattus norvegicus]","gi|672082209|ref|XM_341541.7|",1164,0,"PREDICTED: Rattus norvegicus similar to hypothetical protein 4930474N05 (RGD1564129), transcript variant X2, mRNA","Q03386",109,{"v":2e-24,"d":"2.00E-24"},"Ral guanine nucleotide dissociation stimulator",".",".",".",".","pfam00618","RasGEF_N","RasGEF N-terminal motif. A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this motif/domain N-terminal to the RasGef (Cdc25-like) domain.",".",".",".",".","."]
["ENSRNOG00000017444",12,0.771965258,1,0.06456186,11.9569861,3.579781881,0.001092332,0.000669454,"up","yes","Nrsn1","protein_coding","chr17:39806238-39823813:+","gi|148700512|gb|EDL32459.1|",979,{"v":1E-127,"d":"1.00E-127"},"neurensin 1, isoform CRA_b, partial [Mus musculus]","gi|187937119|ref|NM_001106109.2|",1373,0,"Rattus norvegicus neurensin 1 (Nrsn1), mRNA","P97799",334,{"v":2e-111,"d":"2.00E-111"},"Neurensin-1",".",".",".",".","pfam14927","Neurensin","Neurensin. The neurensin family includes the neuronal membrane proteins neurensin-1 and neurensin-2. Neurensin-1 plays a role in neurite extension.","GO:0007399|nervous system development;","GO:0016021|integral component of membrane;GO:0030133|transport vesicle;GO:0030426|growth cone;GO:0031410|cytoplasmic vesicle;GO:0043005|neuron projection;GO:0043025|neuronal cell body;",".",".","."]
["ENSRNOG00000031927",12,0.771965258,1,0.06456186,11.9569861,3.579781881,0.001092332,0.000669454,"up","yes","Klk6","protein_coding","chr1:94280340-94286121:+","gi|9506997|ref|NP_062048.1|",1349,0,"kallikrein-6 precursor [Rattus norvegicus]","gi|672036301|ref|XM_006228982.2|",897,0,"PREDICTED: Rattus norvegicus kallikrein related-peptidase 6 (Klk6), transcript variant X1, mRNA","Q92876",361,{"v":7e-124,"d":"7.00E-124"},"Kallikrein-6","mlr3307",117,{"v":3e-29,"d":"3.00E-29"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;GO:0010975|regulation of neuron projection development;GO:0045745|positive regulation of G protein-coupled receptor signaling pathway;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005737|cytoplasm;GO:0030141|secretory granule;","GO:0004252|serine-type endopeptidase activity;GO:0008233|peptidase activity;","K08667","KLK6, PRSS9; kallikrein 6 [EC:3.4.21.-]"]
["ENSRNOG00000046151",12,0.771965258,1,0.06456186,11.9569861,3.579781881,0.001092332,0.000669454,"up","yes","Tubb1","protein_coding","chr3:163247967-163256063:+","gi|109471451|ref|XP_001055765.1|",2238,0,"PREDICTED: tubulin beta-1 chain [Rattus norvegicus]","gi|672017834|ref|XM_001055765.5|",1672,0,"PREDICTED: Rattus norvegicus tubulin, beta 1 class VI (Tubb1), mRNA","A2AQ07",857,0,"Tubulin beta-1 chain","ECU03g0820i",661,0,"COG5023","pfam03953","Tubulin_C","Tubulin C-terminal domain. This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).","GO:0000226|microtubule cytoskeleton organization;GO:0000278|mitotic cell cycle;GO:0007017|microtubule-based process;GO:0051225|spindle assembly;","GO:0005737|cytoplasm;GO:0005874|microtubule;","GO:0003924|GTPase activity;GO:0005200|structural constituent of cytoskeleton;GO:0005525|GTP binding;","K07375","TUBB; tubulin beta"]
["ENSRNOG00000059753",12,0.771965258,1,0.06456186,11.9569861,3.579781881,0.001092332,0.000669454,"up","yes","Gys2","protein_coding","chr4:175365054-175406228:-","gi|752993063|ref|NP_037221.2|",3501,0,"glycogen [starch] synthase, liver [Rattus norvegicus]","gi|752993062|ref|NM_013089.2|",2574,0,"Rattus norvegicus glycogen synthase 2 (Gys2), mRNA","P17625",1349,0,"Glycogen [starch] synthase, liver","YFR015c",671,0,"COG0438","pfam05693","Glycogen_syn","Glycogen synthase. This family consists of the eukaryotic glycogen synthase proteins GYS1, GYS2 and GYS3. Glycogen synthase (GS) is the enzyme responsible for the synthesis of -1,4-linked glucose chains in glycogen. It is the rate limiting enzyme in the synthesis of the polysaccharide, and its activity is highly regulated through phosphorylation at multiple sites and also by allosteric effectors, mainly glucose 6-phosphate (G6P).","GO:0005977|glycogen metabolic process;GO:0005978|glycogen biosynthetic process;GO:0009749|response to glucose;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0005938|cell cortex;GO:0030864|cortical actin cytoskeleton;GO:0043265|ectoplasm;","GO:0004373|glycogen (starch) synthase activity;GO:0005536|glucose binding;","K00693","GYS; glycogen synthase [EC:2.4.1.11]"]
["ENSRNOG00000064934",12,0.771965258,1,0.06456186,11.9569861,3.579781881,0.001092332,0.000669454,"up","yes","ENSRNOG00000064934","lncRNA","chr1:243164572-243168980:-",".",".",".",".","gi|32362325|gb|AC105487.6|",1625,0,"Rattus norvegicus 1 BAC CH230-229J7 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam11894","DUF3414","Protein of unknown function (DUF3414). This family of proteins are functionally uncharacterized. The family is found in eukaryotes and has a conserved LLG sequence motif.",".",".",".",".","."]
["ENSRNOG00000057256",25,1.608260955,7,0.451933018,3.558626814,1.831320648,1.096044E-3,0.000671297,"up","yes","Slc19a3","protein_coding","chr9:84277024-84299337:-","gi|157822875|ref|NP_001101698.1|",2539,0,"thiamine transporter 2 [Rattus norvegicus]","gi|157822874|ref|NM_001108228.1|",1579,0,"Rattus norvegicus solute carrier family 19 member 3 (Slc19a3), mRNA","Q99PL8",859,0,"Thiamine transporter 2",".",".",".",".","pfam01770","Folate_carrier","Reduced folate carrier. The reduced folate carrier (a transmembrane glycoprotein) transports reduced folate into mammalian cells via the carrier mediated mechanism (as opposed to the receptor mediated mechanism) it also transports cytotoxic folate analogues used in chemotherapy, such as methotrexate (MTX). Mammalian cells have an absolute requirement for exogenous folates which are needed for growth, and biosynthesis of macromolecules.","GO:0055085|transmembrane transport;GO:0071934|thiamine transmembrane transport;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0015234|thiamine transmembrane transporter activity;","K14610","SLC19A2_3, THTR; solute carrier family 19 (thiamine transporter), member 2/3"]
["ENSRNOG00000014870",32,2.058574022,11,0.710180456,2.898663296,1.535387762,0.001115679,0.000682738,"up","yes","Slc13a5","protein_coding","chr10:56866249-56890945:-","gi|564372546|ref|XP_006246664.1|",2975,0,"PREDICTED: solute carrier family 13 member 5 isoform X1 [Rattus norvegicus]","gi|672067721|ref|XM_006246602.2|",3501,0,"PREDICTED: Rattus norvegicus solute carrier family 13 (sodium-dependent citrate transporter), member 5 (Slc13a5), transcript variant X1, mRNA","Q8CJ44",1047,0,"Solute carrier family 13 member 5","SA1732",238,{"v":1e-66,"d":"1.00E-66"},"COG0471","pfam00939","Na_sulph_symp","Sodium:sulfate symporter transmembrane region. There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.","GO:0006814|sodium ion transport;GO:0006842|tricarboxylic acid transport;GO:0015729|oxaloacetate transport;GO:0015741|fumarate transport;GO:0015742|alpha-ketoglutarate transport;GO:0015744|succinate transport;GO:0015746|citrate transport;GO:0035674|tricarboxylic acid transmembrane transport;GO:0071285|cellular response to lithium ion;GO:0071422|succinate transmembrane transport;GO:0098656|anion transmembrane transport;","GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;","GO:0005343|organic acid:sodium symporter activity;GO:0015137|citrate transmembrane transporter activity;GO:0015141|succinate transmembrane transporter activity;GO:0015142|tricarboxylic acid transmembrane transporter activity;GO:0017153|sodium:dicarboxylate symporter activity;","K14445","SLC13A2_3_5; solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2/3/5"]
["ENSRNOG00000052510",19,1.222278326,4,0.258247439,4.732973663,2.242746894,0.001172046,7.15239E-4,"up","yes","Wnt10a","protein_coding","chr9:76349931-76362400:+","gi|157817686|ref|NP_001101697.1|",1848,0,"protein Wnt-10a precursor [Rattus norvegicus]","gi|157817685|ref|NM_001108227.1|",2456,0,"Rattus norvegicus wingless-type MMTV integration site family, member 10A (Wnt10a), mRNA","P70701",707,0,"Protein Wnt-10a",".",".",".",".","pfam00110","wnt","wnt family. Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.","GO:0001942|hair follicle development;GO:0008150|biological_process;GO:0010628|positive regulation of gene expression;GO:0014033|neural crest cell differentiation;GO:0030182|neuron differentiation;GO:0031069|hair follicle morphogenesis;GO:0042476|odontogenesis;GO:0042487|regulation of odontogenesis of dentin-containing tooth;GO:0043586|tongue development;GO:0043588|skin development;GO:0045165|cell fate commitment;GO:0048730|epidermis morphogenesis;GO:0048733|sebaceous gland development;GO:0060070|canonical Wnt signaling pathway;GO:0071560|cellular response to transforming growth factor beta stimulus;","GO:0005575|cellular_component;GO:0005615|extracellular space;","GO:0003674|molecular_function;GO:0005109|frizzled binding;GO:0005125|cytokine activity;GO:0048018|receptor ligand activity;","K01357","WNT10; wingless-type MMTV integration site family, member 10"]
["ENSRNOG00000012566",21,1.350939202,5,0.322809298,4.184945134,2.065208709,1.194446E-3,0.00072813,"up","yes","Kcnv2","protein_coding","chr1:224999552-225014062:+","gi|157822321|ref|NP_001099840.1|",2749,0,"potassium voltage-gated channel subfamily V member 2 [Rattus norvegicus]","gi|157822320|ref|NM_001106370.1|",5195,0,"Rattus norvegicus potassium voltage-gated channel modifier subfamily V member 2 (Kcnv2), mRNA","Q8CFS6",996,0,"Potassium voltage-gated channel subfamily V member 2","DR0830",80.1,{"v":5E-15,"d":"5.00E-15"},"COG1226","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0034765|regulation of ion transmembrane transport;GO:0051260|protein homooligomerization;GO:0071805|potassium ion transmembrane transport;","GO:0008076|voltage-gated potassium channel complex;GO:0016021|integral component of membrane;","GO:0005249|voltage-gated potassium channel activity;","K04935","KCNV2, KV8.2; potassium channel subfamily V member 2"]
["ENSRNOG00000069402",21,1.350939202,5,0.322809298,4.184945134,2.065208709,1.194446E-3,0.00072813,"up","yes","ENSRNOG00000069402","lncRNA","chr1:20235912-20250149:-",".",".",".",".","gi|755533507|ref|XR_871535.1|",579,0,"PREDICTED: Mus musculus predicted gene, 36313 (Gm36313), transcript variant X10, ncRNA",".",".",".",".",".",".",".",".","pfam02928","zf-C5HC2","C5HC2 zinc finger. Predicted zinc finger with eight potential zinc ligand binding residues. This domain is found in Jumonji. This domain may have a DNA binding function.",".",".",".",".","."]
["ENSRNOG00000056973",46,2.959200157,20,1.291237193,2.291755668,1.196453242,0.001239468,0.00075477,"up","yes","Snora17","snoRNA","chr3:9466700-9466831:-",".",".",".",".","gi|908662265|tpe|LN871987.1|",108,{"v":3e-48,"d":"3.00E-48"},"TPA: Mus musculus SNORA17 (ACA17) gene for small nucleolar RNA SNORA17 (ACA17)",".",".",".",".",".",".",".",".","pfam15257","DUF4590","Domain of unknown function (DUF4590). This family of proteins remains to be characterized and is a domain of unknown function. This domain family is found in eukaryotes, and is approximately 120 amino acids in length. There are two conserved sequence motifs: CCE and PCY. In humans, the gene encoding this protein lies in the position, chromosome 1 open reading frame 173.",".",".",".",".","."]
["ENSRNOG00000067389",38,2.444556651,15,0.968427895,2.52425262,1.335856298,1.378158E-3,0.00083646,"up","yes","ENSRNOG00000067389","lncRNA","chr20:47679707-47798211:-","gi|537225155|gb|ERE83089.1|",471,{"v":5e-50,"d":"5.00E-50"},"putative ribosome biogeneis protein NSA2 like protein [Cricetulus griseus]","gi|672031914|ref|XR_343957.2|",737,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102554815 (LOC102554815), transcript variant X4, ncRNA","O95478",166,{"v":7e-44,"d":"7.00E-44"},"Ribosome biogenesis protein NSA2 homolog","SPCP1E11.08",119,{"v":2e-28,"d":"2.00E-28"},"COG2007","pfam01201","Ribosomal_S8e","Ribosomal protein S8e.",".",".",".",".","."]
["ENSRNOG00000022964",28,1.801252269,9,0.581056737,3.099959358,1.632249301,0.001435177,0.000869127,"up","yes","Rnf222","protein_coding","chr10:53596751-53603300:+","gi|116089300|ref|NP_796034.2|",788,{"v":5e-95,"d":"5.00E-95"},"RING finger protein 222 [Mus musculus]","gi|672067984|ref|XM_008767846.1|",2685,0,"PREDICTED: Rattus norvegicus ring finger protein 222 (Rnf222), transcript variant X4, mRNA","Q8CEF8",308,{"v":2e-96,"d":"2.00E-96"},"RING finger protein 222",".",".",".",".","pfam13639","zf-RING_2","Ring finger domain.",".","GO:0016021|integral component of membrane;","GO:0046872|metal ion binding;",".","."]
["ENSRNOG00000023474",28,1.801252269,9,0.581056737,3.099959358,1.632249301,0.001435177,0.000869127,"up","yes","Dazl","protein_coding","chr9:10695592-10712323:+","gi|564367198|ref|XP_006244539.1|",1324,{"v":3E-171,"d":"3.00E-171"},"PREDICTED: deleted in azoospermia-like isoform X1 [Rattus norvegicus]","gi|672064401|ref|XM_006244477.2|",2687,0,"PREDICTED: Rattus norvegicus deleted in azoospermia-like (Dazl), transcript variant X1, mRNA","Q64368",513,{"v":2e-172,"d":"2.00E-172"},"Deleted in azoospermia-like",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0001556|oocyte maturation;GO:0007147|female meiosis II;GO:0007281|germ cell development;GO:0007283|spermatogenesis;GO:0045836|positive regulation of meiotic nuclear division;GO:0045948|positive regulation of translational initiation;GO:0070935|3'-UTR-mediated mRNA stabilization;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005844|polysome;GO:0032991|protein-containing complex;","GO:0003730|mRNA 3'-UTR binding;GO:0008494|translation activator activity;GO:0042802|identical protein binding;","K24980","DAZ; deleted in azoospermia protein"]
["ENSRNOG00000064838",28,1.801252269,9,0.581056737,3.099959358,1.632249301,0.001435177,0.000869127,"up","yes","ENSRNOG00000064838","protein_coding","chr2:23582194-23585966:-","gi|300794684|ref|NP_001178886.1|",841,{"v":1e-101,"d":"1.00E-101"},"DNA mismatch repair protein Msh3 [Rattus norvegicus]","gi|672041094|ref|XM_006231768.2|",602,0,"PREDICTED: Rattus norvegicus mutS homolog 3 (Msh3), transcript variant X1, mRNA","P13705",281,{"v":5e-86,"d":"5.00E-86"},"DNA mismatch repair protein Msh3",".",".",".",".","pfam12349","Sterol-sensing","Sterol-sensing domain of SREBP cleavage-activation. Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.",".",".",".",".","."]
["ENSRNOG00000004341",50,3.216521909,23,1.484922772,2.16612067,1.115113614,0.001458749,0.000882934,"up","yes","ENSRNOG00000004341","protein_coding","chr13:42188609-42201426:+","gi|281306791|ref|NP_001094258.1|",2615,0,"specifically androgen-regulated gene protein [Rattus norvegicus]","gi|281306790|ref|NM_001100788.1|",2866,0,"Rattus norvegicus similar to specifically androgen-regulated protein (LOC498222), mRNA","Q499V8",1011,0,"Specifically androgen-regulated gene protein",".",".",".",".","pfam15385","SARG","Specifically androgen-regulated gene protein. This family of proteins is found in eukaryotes, the function of this protein is still unknown but it is thought to be an androgen receptor. Protein expression is up-regulated in the presence of androgens, but not in the presence of glucocorticoids. SARG tends to be highly expressed in prostate tissue. Proteins in this family are typically between 340 and 587 amino acids in length. There is a conserved EETI sequence motif.",".","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;",".",".","."]
["ENSRNOG00000068492",50,3.216521909,23,1.484922772,2.16612067,1.115113614,0.001458749,0.000882934,"up","yes","Omp","protein_coding","chr1:152433652-152441922:-","gi|537195894|gb|ERE78208.1|",871,{"v":4e-101,"d":"4.00E-101"},"olfactory marker protein [Cricetulus griseus]","gi|405963|gb|M26926.1|RNM26926",3288,0,"Rat olfactory marker protein (OMP) gene, complete cds","P08523",332,{"v":2e-102,"d":"2.00E-102"},"Olfactory marker protein",".",".",".",".","pfam06554","Olfactory_mark","Olfactory marker protein. This family consists of several olfactory marker proteins. Expression of the olfactory marker protein (OMP) is highly restricted to mature olfactory receptor neurons in virtually all vertebrate species from fish to man.",".",".",".",".","."]
["ENSRNOG00000029980",44,2.83053928,19,1.226675333,2.307488545,1.206323486,0.001476496,0.000893014,"up","yes","Zbtb16","protein_coding","chr8:48994566-49177011:-","gi|61557206|ref|NP_001013199.1|",3523,0,"zinc finger and BTB domain-containing protein 16 [Rattus norvegicus]","gi|55669172|gb|AY781103.1|",2331,0,"Rattus norvegicus strain BN/Cub promyelocytic leukemia zinc finger protein (Zfp145) mRNA, complete cds","Q05516",1308,0,"Zinc finger and BTB domain-containing protein 16",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001501|skeletal system development;GO:0001823|mesonephros development;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007417|central nervous system development;GO:0008285|negative regulation of cell proliferation;GO:0009880|embryonic pattern specification;GO:0009952|anterior/posterior pattern specification;GO:0030097|hemopoiesis;GO:0030326|embryonic limb morphogenesis;GO:0032332|positive regulation of chondrocyte differentiation;GO:0034504|protein localization to nucleus;GO:0035116|embryonic hindlimb morphogenesis;GO:0035136|forelimb morphogenesis;GO:0035137|hindlimb morphogenesis;GO:0042733|embryonic digit morphogenesis;GO:0043065|positive regulation of apoptotic process;GO:0043931|ossification involved in bone maturation;GO:0045600|positive regulation of fat cell differentiation;GO:0045638|negative regulation of myeloid cell differentiation;GO:0045778|positive regulation of ossification;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048133|male germ-line stem cell asymmetric division;GO:0051138|positive regulation of NK T cell differentiation;GO:0051216|cartilage development;GO:0061036|positive regulation of cartilage development;","GO:0005634|nucleus;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016604|nuclear body;GO:0016605|PML body;GO:0016607|nuclear speck;GO:0017053|transcriptional repressor complex;GO:0032991|protein-containing complex;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001222|transcription corepressor binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003690|double-stranded DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0005515|protein binding;GO:0008022|protein C-terminus binding;GO:0019904|protein domain specific binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;","K10055","ZBTB16, PLZF; zinc finger and BTB domain-containing protein 16"]
["ENSRNOG00000000384",10,0.643304382,0,0.03228093,19.92831016,4.316747476,0.0015572,0.000936568,"up","yes","Atoh7","protein_coding","chr20:25530826-25531275:-","gi|281427231|ref|NP_001163953.1|",557,{"v":3e-70,"d":"3.00E-70"},"protein atonal homolog 7 [Rattus norvegicus]","gi|281427230|ref|NM_001170482.1|",450,0,"Rattus norvegicus atonal bHLH transcription factor 7 (Atoh7), mRNA","Q9Z2E5",211,{"v":8e-69,"d":"8.00E-69"},"Protein atonal homolog 7",".",".",".",".","pfam00010","HLH","Helix-loop-helix DNA-binding domain.","GO:0003407|neural retina development;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007623|circadian rhythm;GO:0008150|biological_process;GO:0009649|entrainment of circadian clock;GO:0021554|optic nerve development;GO:0030182|neuron differentiation;GO:0043153|entrainment of circadian clock by photoperiod;","GO:0005575|cellular_component;GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0046983|protein dimerization activity;GO:1990837|sequence-specific double-stranded DNA binding;","K09083","ATOH1_7; atonal protein 1/7"]
["ENSRNOG00000006142",10,0.643304382,0,0.03228093,19.92831016,4.316747476,0.0015572,0.000936568,"up","yes","Mymk","protein_coding","chr3:10388361-10397343:-","gi|672044873|ref|XP_008759857.1|",1145,{"v":1e-148,"d":"1.00E-148"},"PREDICTED: protein myomaker isoform X1 [Rattus norvegicus]","gi|197386535|ref|NM_001134517.1|",1418,0,"Rattus norvegicus transmembrane protein 8C (Tmem8c), mRNA","Q9D1N4",390,{"v":5e-133,"d":"5.00E-133"},"Protein myomaker",".",".",".",".","pfam12036","DUF3522","Protein of unknown function (DUF3522). This family of proteins is functionally uncharacterized. This protein is found in eukaryotes. Proteins in this family are typically between 220 to 787 amino acids in length.","GO:0007520|myoblast fusion;GO:0014905|myoblast fusion involved in skeletal muscle regeneration;GO:0043403|skeletal muscle tissue regeneration;GO:0045026|plasma membrane fusion;GO:1904206|positive regulation of skeletal muscle hypertrophy;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0030173|integral component of Golgi membrane;",".",".","."]
["ENSRNOG00000010261",10,0.643304382,0,0.03228093,19.92831016,4.316747476,0.0015572,0.000936568,"up","yes","ENSRNOG00000010261","protein_coding","chr15:24226691-24228561:+","gi|564385932|ref|XP_006251930.1|",1192,{"v":2e-163,"d":"2.00E-163"},"PREDICTED: inactive ribonuclease-like protein 10 isoform X1 [Rattus norvegicus]","gi|672077518|ref|XM_006251868.2|",750,0,"PREDICTED: Rattus norvegicus ribonuclease, RNase A family, 10 (non-active) (Rnase10), transcript variant X1, mRNA","Q5GAM0",389,{"v":5e-136,"d":"5.00E-136"},"Inactive ribonuclease-like protein 10",".",".",".",".","pfam00074","RnaseA","Pancreatic ribonuclease. Ribonucleases. Members include pancreatic RNAase A and angiogenins. Structure is an alpha+beta fold -- long curved beta sheet and three helices.","GO:0003382|epithelial cell morphogenesis;GO:0007338|single fertilization;GO:0008584|male gonad development;GO:0022409|positive regulation of cell-cell adhesion;GO:0034113|heterotypic cell-cell adhesion;GO:0072520|seminiferous tubule development;GO:0080154|regulation of fertilization;GO:1902093|positive regulation of flagellated sperm motility;","GO:0005576|extracellular region;","GO:0003676|nucleic acid binding;",".","."]
["ENSRNOG00000017725",10,0.643304382,0,0.03228093,19.92831016,4.316747476,0.0015572,0.000936568,"up","yes","Pnlip","protein_coding","chr1:257798581-257811654:+","gi|149040500|gb|EDL94538.1|",2514,0,"pancreatic lipase, isoform CRA_a [Rattus norvegicus]","gi|402692544|ref|NM_013161.2|",1439,0,"Rattus norvegicus pancreatic lipase (Pnlip), mRNA","P27657",967,0,"Pancreatic triacylglycerol lipase",".",".",".",".","pfam00151","Lipase","Lipase.","GO:0006629|lipid metabolic process;GO:0009791|post-embryonic development;GO:0016042|lipid catabolic process;GO:0030299|intestinal cholesterol absorption;GO:0033993|response to lipid;GO:0042572|retinol metabolic process;GO:0043434|response to peptide hormone;GO:0061365|positive regulation of triglyceride lipase activity;","GO:0005615|extracellular space;","GO:0004806|triglyceride lipase activity;GO:0016298|lipase activity;GO:0046872|metal ion binding;GO:0047376|all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity;","K14073","PNLIP, PL; pancreatic triacylglycerol lipase [EC:3.1.1.3]"]
["ENSRNOG00000021656",10,0.643304382,0,0.03228093,19.92831016,4.316747476,0.0015572,0.000936568,"up","yes","RGD1359334","protein_coding","chr2:182814793-182818512:-","gi|56090341|ref|NP_001007639.1|",1382,0,"protein MENT precursor [Rattus norvegicus]","gi|56090340|ref|NM_001007638.1|",1218,0,"Rattus norvegicus similar to hypothetical protein FLJ20519 (RGD1359334), mRNA","Q5XI62",536,0,"Protein MENT",".",".",".",".","pfam15322","PMSI1","Protein missing in infertile sperm 1, putative. This family of proteins is found in eukaryotes. Proteins in this family are typically between 249 and 341 amino acids in length.","GO:0042127|regulation of cell proliferation;","GO:0005576|extracellular region;",".","K25382","MENT; protein MENT"]
["ENSRNOG00000049523",10,0.643304382,0,0.03228093,19.92831016,4.316747476,0.0015572,0.000936568,"up","yes","AC097153.2","pseudogene","chr2:5243284-5243809:+","gi|61557307|ref|NP_001013231.1|",551,{"v":6e-69,"d":"6.00E-69"},"centromere protein R [Rattus norvegicus]","gi|672053206|ref|XM_008763884.1|",243,{"v":1e-122,"d":"1.00E-122"},"PREDICTED: Rattus norvegicus integrin beta 3 binding protein (beta3-endonexin) (Itgb3bp), transcript variant X5, mRNA","Q5U1Z7",216,{"v":2E-70,"d":"2.00E-70"},"Centromere protein R",".",".",".",".","pfam06729","CENP-R","Kinetochore component, CENP-R. This family consists of mammalian kinetochore sub-complex proteins CENP-R, also referred to as nuclear receptor co-activator NRIF3 proteins. NRIF3 exhibits a distinct receptor specificity in interacting with and potentiating the activity of only TRs and RXRs but not other examined nuclear receptors. NRIF3 as a co-regulator that possesses both transactivation and transrepression domains and/or functions. Collectively, the NRIF3 family of co-regulators may play dual roles in mediating both positive and negative regulatory effects on gene expression. CENP-R is one of the 15 components that make up the constitutive centromere associated complex (CCAN) part of the kinetochore. A sub-complex of CCAN, consisting of CENP-P/O/R/Q/U self-assembles on kinetochores with varying stoichiometry and undergoes a pre-mitotic maturation step. Kinetochore assembly is a cell cycle regulated multi-step process. The initial step occurs during interphase and involves loading of the 15-subunit constitutive centromere associated complex (CCAN). Kinetochores are multi-protein megadalton assemblies that are required for attachment of microtubules to centromeres and, in turn, the segregation of chromosomes in mitosis.",".",".",".",".","."]
["ENSRNOG00000016388",14,0.900626135,2,0.129123719,6.974908556,2.802174303,0.001581302,0.000950263,"up","yes","Sphkap","protein_coding","chr9:84510964-84657559:-","gi|564369074|ref|XP_006245296.1|",8737,0,"PREDICTED: A-kinase anchor protein SPHKAP isoform X5 [Rattus norvegicus]","gi|672065639|ref|XM_006245234.2|",5215,0,"PREDICTED: Rattus norvegicus SPHK1 interactor, AKAP domain containing (Sphkap), transcript variant X5, mRNA","P0C6C0",3224,0,"A-kinase anchor protein SPHKAP",".",".",".",".","pfam05716","AKAP_110","A-kinase anchor protein 110 kDa (AKAP 110). This family consists of several mammalian protein kinase A anchoring protein 3 (PRKA3) or A-kinase anchor protein 110 kDa (AKAP 110) sequences. Agents that increase intracellular cAMP are potent stimulators of sperm motility. Anchoring inhibitor peptides, designed to disrupt the interaction of the cAMP-dependent protein kinase A (PKA) with A kinase-anchoring proteins (AKAPs), are potent inhibitors of sperm motility. PKA anchoring is a key biochemical mechanism controlling motility. AKAP110 shares compartments with both RI and RII isoforms of PKA and may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.",".","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0030018|Z disc;","GO:0051018|protein kinase A binding;",".","."]
["ENSRNOG00000034087",14,0.900626135,2,0.129123719,6.974908556,2.802174303,0.001581302,0.000950263,"up","yes","Krt42","protein_coding","chr10:85185181-85192595:-","gi|57012446|ref|NP_001008816.1|",2224,0,"keratin, type I cytoskeletal 42 [Rattus norvegicus]","gi|57012445|ref|NM_001008816.1|",1359,0,"Rattus norvegicus keratin 42 (Krt42), mRNA","Q6IFU7",861,0,"Keratin, type I cytoskeletal 42",".",".",".",".","pfam00038","Filament","Intermediate filament protein.",".","GO:0005737|cytoplasm;GO:0005882|intermediate filament;","GO:0005198|structural molecule activity;","K07604","KRT1; type I keratin, acidic"]
["ENSRNOG00000065556",14,0.900626135,2,0.129123719,6.974908556,2.802174303,0.001581302,0.000950263,"up","yes","ENSRNOG00000065556","pseudogene","chr12:8843401-8845916:+","gi|568939055|ref|XP_006504916.1|",817,{"v":1e-104,"d":"1.00E-104"},"PREDICTED: predicted gene 6370 isoform X1 [Mus musculus]","gi|755521300|ref|XM_006541198.2|",233,{"v":8e-117,"d":"8.00E-117"},"PREDICTED: Mus musculus RIKEN cDNA 4933421I07 gene (4933421I07Rik), transcript variant X1, mRNA","Q03386",67,{"v":6E-11,"d":"6.00E-11"},"Ral guanine nucleotide dissociation stimulator",".",".",".",".","pfam00618","RasGEF_N","RasGEF N-terminal motif. A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this motif/domain N-terminal to the RasGef (Cdc25-like) domain.",".",".",".",".","."]
["ENSRNOG00000067908",14,0.900626135,2,0.129123719,6.974908556,2.802174303,0.001581302,0.000950263,"up","yes","Gadl1","protein_coding","chr8:115605873-115784410:+","gi|109485549|ref|XP_001076997.1|",3169,0,"PREDICTED: glutamate decarboxylase-like protein 1 isoform X1 [Rattus norvegicus]","gi|564310763|ref|XM_001076997.4|",2348,0,"PREDICTED: Rattus norvegicus glutamate decarboxylase-like 1 (Gadl1), transcript variant X1, mRNA","Q80WP8",1015,0,"Acidic amino acid decarboxylase GADL1","BH2623",205,{"v":1E-56,"d":"1.00E-56"},"COG0076","pfam00282","Pyridoxal_deC","Pyridoxal-dependent decarboxylase conserved domain.",".",".",".",".","."]
["ENSRNOG00000063293",31,1.994243584,11,0.710180456,2.808080068,1.489584072,1.704753E-3,1.02144E-3,"up","yes","Pdrg1","lncRNA","chr3:141476501-141483858:-","gi|62244083|ref|NP_001014762.1|",540,{"v":3e-61,"d":"3.00E-61"},"p53 and DNA damage-regulated protein 1 [Rattus norvegicus]","gi|86439996|gb|AC129342.5|",1363,0,"Rattus norvegicus BAC CH230-229B21 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q642A0",212,{"v":1E-62,"d":"1.00E-62"},"p53 and DNA damage-regulated protein 1",".",".",".",".","pfam01920","Prefoldin_2","Prefoldin subunit. This family includes prefoldin subunits that are not detected by pfam02996.",".",".",".",".","."]
["ENSRNOG00000064489",24,1.543930516,7,0.451933018,3.416281742,1.772426959,1.762595E-3,1.054328E-3,"up","yes","ENSRNOG00000064489","protein_coding","chr17:54219696-54230645:+","gi|148701441|gb|EDL33388.1|",249,{"v":4e-23,"d":"4.00E-23"},"mCG1045525, partial [Mus musculus]","gi|37591381|gb|AC124336.10|",230,{"v":4e-115,"d":"4.00E-115"},"Mus musculus chromosome 18, clone RP24-125A2, complete sequence",".",".",".",".",".",".",".",".","pfam10436","BCDHK_Adom3","Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase. Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal.",".",".",".",".","."]
["ENSRNOG00000057072",34,2.187234898,13,0.839304176,2.60600979,1.381842504,0.001899866,1.131485E-3,"up","yes","Slc12a3","protein_coding","chr19:10631393-10669091:-","gi|158186720|ref|NP_062218.3|",5208,0,"solute carrier family 12 member 3 [Rattus norvegicus]","gi|158186719|ref|NM_019345.3|",3683,0,"Rattus norvegicus solute carrier family 12 (sodium/chloride transporters), member 3 (Slc12a3), mRNA","P55018",2006,0,"Solute carrier family 12 member 3","SPBC18H10.16",257,{"v":7e-70,"d":"7.00E-70"},"COG0531","pfam00324","AA_permease","Amino acid permease.","GO:0006814|sodium ion transport;GO:0006821|chloride transport;GO:0006884|cell volume homeostasis;GO:0015698|inorganic anion transport;GO:0035725|sodium ion transmembrane transport;GO:0055064|chloride ion homeostasis;GO:0055075|potassium ion homeostasis;GO:0055078|sodium ion homeostasis;GO:0070294|renal sodium ion absorption;GO:1902476|chloride transmembrane transport;GO:1990573|potassium ion import across plasma membrane;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0031982|vesicle;GO:0070062|extracellular exosome;","GO:0008511|sodium:potassium:chloride symporter activity;GO:0015081|sodium ion transmembrane transporter activity;GO:0015377|cation:chloride symporter activity;GO:0015378|sodium:chloride symporter activity;GO:0015379|potassium:chloride symporter activity;GO:0019899|enzyme binding;","K14426","SLC12A3, TSC; solute carrier family 12 (sodium/chloride transporter), member 3"]
["ENSRNOG00000066901",34,2.187234898,13,0.839304176,2.60600979,1.381842504,0.001899866,1.131485E-3,"up","yes","ENSRNOG00000066901","protein_coding","chr17:42425861-42486187:-","gi|724873241|ref|XP_010371584.1|",487,{"v":3e-59,"d":"3.00E-59"},"PREDICTED: histone H2B type 2-F isoform X1 [Rhinopithecus roxellana]","gi|672082112|ref|XM_006254120.2|",358,0,"PREDICTED: Rattus norvegicus histone cluster 1, H2bc-like (LOC100359692), mRNA","Q5R893",187,{"v":1E-59,"d":"1.00E-59"},"Histone H2B type 1",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.",".",".",".",".","."]
["ENSRNOG00000015682",20,1.286608764,5,0.322809298,3.985662032,1.994819381,0.001989319,0.001181549,"up","yes","Kel","protein_coding","chr4:70568243-70585631:-","gi|300798081|ref|NP_001178540.1|",3626,0,"kell blood group glycoprotein [Rattus norvegicus]","gi|672049507|ref|XM_006236377.2|",2456,0,"PREDICTED: Rattus norvegicus Kell blood group, metallo-endopeptidase (Kel), transcript variant X1, mRNA","Q9EQF2",1257,0,"Kell blood group glycoprotein homolog","MA2001",208,{"v":2e-56,"d":"2.00E-56"},"COG3590","pfam05649","Peptidase_M13_N","Peptidase family M13. M13 peptidases are well-studied proteases found in a wide range of organisms including mammals and bacteria. In mammals they participate in processes such as cardiovascular development, blood-pressure regulation, nervous control of respiration, and regulation of the function of neuropeptides in the central nervous system. In bacteria they may be used for digestion of milk.","GO:0006874|cellular calcium ion homeostasis;GO:0008361|regulation of cell size;GO:0010961|cellular magnesium ion homeostasis;GO:0016485|protein processing;GO:0031133|regulation of axon diameter;GO:0042552|myelination;GO:0048741|skeletal muscle fiber development;GO:1901380|negative regulation of potassium ion transmembrane transport;","GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0004222|metalloendopeptidase activity;GO:0008237|metallopeptidase activity;GO:0046872|metal ion binding;","K06577","KEL, CD238; Kell blood group glycoprotein [EC:3.4.24.-]"]
["ENSRNOG00000030318",18,1.157947887,4,0.258247439,4.483869786,2.164744382,0.001997148,0.001185936,"up","yes","Gpr83","protein_coding","chr8:11693540-11704028:+","gi|17939358|ref|NP_536336.1|",1979,0,"probable G-protein coupled receptor 83 precursor [Rattus norvegicus]","gi|17939357|ref|NM_080411.1|",3565,0,"Rattus norvegicus G protein-coupled receptor 83 (Gpr83), mRNA","P30731",745,0,"Probable G-protein coupled receptor 83",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007218|neuropeptide signaling pathway;GO:0051384|response to glucocorticoid;","GO:0005887|integral component of plasma membrane;GO:0005929|cilium;GO:0097730|non-motile cilium;","GO:0004983|neuropeptide Y receptor activity;GO:0008188|neuropeptide receptor activity;","K04210","GPR83, GPR72; G protein-coupled receptor 83"]
["ENSRNOG00000067655",49,3.152191471,23,1.484922772,2.122798256,1.085967269,0.002042638,1.211689E-3,"up","yes","ENSRNOG00000067655","protein_coding","chr1:181402275-181417714:-","gi|795122734|ref|XP_011788908.1|",2276,0,"PREDICTED: LOW QUALITY PROTEIN: fructose-bisphosphate aldolase A [Colobus angolensis palliatus]","gi|672038362|ref|XM_006230209.2|",1453,0,"PREDICTED: Rattus norvegicus aldolase A, fructose-bisphosphate (Aldoa), transcript variant X2, mRNA","P05065",717,0,"Fructose-bisphosphate aldolase A","AGl2190",322,{"v":1E-100,"d":"1.00E-100"},"COG3588","pfam00274","Glycolytic","Fructose-bisphosphate aldolase class-I.",".",".",".",".","."]
["ENSRNOG00000034229",11,0.70763482,1,0.06456186,10.96057059,3.454250999,0.002047326,0.001213713,"up","yes","Serpinb1b","protein_coding","chr17:31320556-31327935:-","gi|293342714|ref|XP_001066387.2|",1932,0,"PREDICTED: leukocyte elastase inhibitor A-like [Rattus norvegicus]","gi|672029959|ref|XM_001066387.4|",1122,0,"PREDICTED: Rattus norvegicus serine (or cysteine) peptidase inhibitor, clade B, member 1b (Serpinb1b), mRNA","Q4G075",632,0,"Leukocyte elastase inhibitor A","MA2246",174,{"v":7e-49,"d":"7.00E-49"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0010951|negative regulation of endopeptidase activity;GO:0032691|negative regulation of interleukin-1 beta production;","GO:0005615|extracellular space;","GO:0004867|serine-type endopeptidase inhibitor activity;","K23425","SERPINB1; leukocyte elastase inhibitor"]
["ENSRNOG00000059092",11,0.70763482,1,0.06456186,10.96057059,3.454250999,0.002047326,0.001213713,"up","yes","Olr154","protein_coding","chr1:158845078-158851922:+","gi|47576371|ref|NP_001000547.1|",1555,0,"olfactory receptor Olr154 [Rattus norvegicus]","gi|49615119|gb|AC113720.6|",2610,0,"Rattus norvegicus 1 BAC CH230-117B1 (Children's Hospital Oakland Research Institute) complete sequence","Q9H346",367,{"v":8e-117,"d":"8.00E-117"},"Olfactory receptor 52D1",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0050911|detection of chemical stimulus involved in sensory perception of smell;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004984|olfactory receptor activity;","K04257","OLFR; olfactory receptor"]
["ENSRNOG00000064874",11,0.70763482,1,0.06456186,10.96057059,3.454250999,0.002047326,0.001213713,"up","yes","ENSRNOG00000064874","protein_coding","chr1:158993924-158995771:-","gi|672038322|ref|XP_008758066.1|",2575,0,"PREDICTED: ubiquitin carboxyl-terminal hydrolase 17-like protein A [Rattus norvegicus]","gi|90855788|gb|AC128039.4|",1563,0,"Rattus norvegicus BAC CH230-394A24 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q7M764",662,0,"Ubiquitin carboxyl-terminal hydrolase 17-like protein E",".",".",".",".","pfam00443","UCH","Ubiquitin carboxyl-terminal hydrolase.",".",".",".",".","."]
["ENSRNOG00000070010",11,0.70763482,1,0.06456186,10.96057059,3.454250999,0.002047326,0.001213713,"up","yes","Hist1h2ak","protein_coding","chr17:42799652-42800381:-","gi|671000624|ref|XP_008691171.1|",551,{"v":3E-68,"d":"3.00E-68"},"PREDICTED: histone H2A type 1-like [Ursus maritimus]","gi|157821614|ref|NM_001109423.1|",393,0,"Rattus norvegicus histone cluster 1, H2ak (Hist1h2ak), mRNA","Q4FZT6",216,{"v":1e-69,"d":"1.00E-69"},"Histone H2A type 3","SPAC19G12.06c",180,{"v":7e-56,"d":"7.00E-56"},"COG5262","pfam00125","Histone","Core histone H2A/H2B/H3/H4.",".",".",".",".","."]
["ENSRNOG00000025489",40,2.573217527,17,1.097551614,2.344507078,1.229284634,0.002092774,1.239113E-3,"up","yes","Pkd2l2","protein_coding","chr18:26007797-26042428:+","gi|157821995|ref|NP_001099626.1|",2887,0,"polycystic kidney disease 2-like 2 protein [Rattus norvegicus]","gi|157821994|ref|NM_001106156.1|",2473,0,"Rattus norvegicus polycystin 2 like 2, transient receptor potential cation channel (Pkd2l2), mRNA","Q9JLG4",994,0,"Polycystic kidney disease 2-like 2 protein",".",".",".",".","pfam08016","PKD_channel","Polycystin cation channel. This family contains the cation channel region of PKD1 and PKD2 proteins.","GO:0050982|detection of mechanical stimulus;GO:0070588|calcium ion transmembrane transport;","GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0005262|calcium channel activity;GO:0005509|calcium ion binding;","K04991","PKD2L2; polycystin 2L2"]
["ENSRNOG00000031947",40,2.573217527,17,1.097551614,2.344507078,1.229284634,0.002092774,1.239113E-3,"up","yes","AABR07071986.1","protein_coding","chr1:180985438-180986209:+","gi|148706231|gb|EDL38178.1|",427,{"v":4E-50,"d":"4.00E-50"},"mCG5564, partial [Mus musculus]","gi|34849735|gb|BC058475.1|",370,0,"Rattus norvegicus ribosomal protein L36, mRNA (cDNA clone MGC:72835 IMAGE:6888196), complete cds","Q5RAZ9",166,{"v":8e-51,"d":"8.00E-51"},"60S ribosomal protein L36","SPCC970.05",87.4,{"v":4e-21,"d":"4.00E-21"},"COG5051","pfam01158","Ribosomal_L36e","Ribosomal protein L36e.",".",".",".",".","."]
["ENSRNOG00000063817",40,2.573217527,17,1.097551614,2.344507078,1.229284634,0.002092774,1.239113E-3,"up","yes","ENSRNOG00000063817","lncRNA","chr10:12601522-12614081:-","gi|537162618|gb|ERE73245.1|",430,{"v":1e-43,"d":"1.00E-43"},"HERV-K-3q27.3 provirus ancestral Pol protein [Cricetulus griseus]","gi|76362955|gb|AC158789.4|",295,{"v":9e-151,"d":"9.00E-151"},"Mus musculus chromosome 5, clone RP23-192C21, complete sequence",".",".",".",".",".",".",".",".","pfam00665","rve","Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyses the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.",".",".",".",".","."]
["ENSRNOG00000069049",27,1.736921831,9,0.581056737,2.989246524,1.579781881,0.002234893,1.320112E-3,"up","yes","ENSRNOG00000069049","lncRNA","chr3:105728113-105733411:-","gi|918590437|ref|XP_013368055.1|",344,{"v":2e-31,"d":"2.00E-31"},"PREDICTED: putative transmembrane protein INAFM2 [Chinchilla lanigera]","gi|354798321|gb|JN962822.1|",2375,0,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele A430105I19Rik:tm1a(KOMP)Ucd; transgenic","P0DMQ5",102,{"v":8e-23,"d":"8.00E-23"},"Putative transmembrane protein INAFM2",".",".",".",".","pfam15018","InaF-motif","TRP-interacting helix. This highly conserved motif is thought to be a transmembrane helix that binds to transient receptor potential (TRP) calcium channel. It is known that proline-rich proteins inactivate tannins found in food compounds, and it is putatively thought that PRR24 does too. This is important since tannins often inhibit the uptake of iron. InaF is a protein required for TRP calcium channel function in Drosophila. TRP-related channels have been suggested to mediate store-operated calcium entry, important for Ca2+ homeostasis in a wide variety of cell types. The amino acid sequence of PRR-24 contains two completely conserved Y residues that may be functionally important. This domain family is found in eukaryotes, and is approximately 40 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000070097",50,3.216521909,24,1.549484632,2.075865642,1.05371307,0.002368235,1.394405E-3,"up","yes","ENSRNOG00000070097","protein_coding","chr1:85530950-85543455:+","gi|12839128|dbj|BAB24441.1|",324,{"v":3E-32,"d":"3.00E-32"},"unnamed protein product [Mus musculus]","gi|672036229|ref|XM_008759297.1|",85,{"v":2e-34,"d":"2.00E-34"},"PREDICTED: Rattus norvegicus THAP domain containing 8 (Thap8), mRNA",".",".",".",".",".",".",".",".","pfam15380","DUF4607","Domain of unknown function (DUF4607). This family of proteins is found in eukaryotes. Proteins in this family are typically between 207 and 359 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000000588",44,2.83053928,20,1.291237193,2.192114118,1.132322904,0.002504893,0.001471531,"up","yes","Slc16a10","protein_coding","chr20:43459709-43567839:-","gi|672086586|ref|XP_008771196.1|",2346,0,"PREDICTED: monocarboxylate transporter 10 isoform X1 [Rattus norvegicus]","gi|672086585|ref|XM_008772974.1|",2481,0,"PREDICTED: Rattus norvegicus solute carrier family 16 (aromatic amino acid transporter), member 10 (Slc16a10), transcript variant X1, mRNA","Q91Y77",904,0,"Monocarboxylate transporter 10","AF0367",50.8,1e-05,"COG0477","pfam07690","MFS_1","Major Facilitator Superfamily.","GO:0006590|thyroid hormone generation;GO:0015801|aromatic amino acid transport;GO:0055085|transmembrane transport;GO:0070327|thyroid hormone transport;GO:0070460|thyroid-stimulating hormone secretion;","GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0030054|cell junction;GO:0043231|intracellular membrane-bounded organelle;","GO:0015173|aromatic amino acid transmembrane transporter activity;GO:0015349|thyroid hormone transmembrane transporter activity;","K08187","SLC16A10; MFS transporter, MCT family, solute carrier family 16 (monocarboxylic acid transporters), member 10"]
["ENSRNOG00000007003",30,1.929913146,11,0.710180456,2.71749684,1.442278358,0.00258741,0.001517976,"up","yes","Mei1","protein_coding","chr7:113590142-113643511:+","gi|194474002|ref|NP_001124027.1|",6455,0,"meiosis inhibitor protein 1 [Rattus norvegicus]","gi|194474001|ref|NM_001130555.1|",4018,0,"Rattus norvegicus meiotic double-stranded break formation protein 1 (Mei1), mRNA","Q9D4I2",2265,0,"Meiosis inhibitor protein 1",".",".",".",".","pfam10373","EST1_DNA_bind","Est1 DNA/RNA binding domain. Est1 is a protein which recruits or activates telomerase at the site of polymerization. This is the DNA/RNA binding domain of EST1.","GO:0000212|meiotic spindle organization;GO:0007127|meiosis I;GO:0007141|male meiosis I;GO:0007276|gamete generation;GO:0007283|spermatogenesis;GO:0007286|spermatid development;GO:0040038|polar body extrusion after meiotic divisions;GO:0045141|meiotic telomere clustering;GO:0048477|oogenesis;GO:0051321|meiotic cell cycle;",".",".","K25318","MEI1; meiosis inhibitor protein 1"]
["ENSRNOG00000031707",33,2.12290446,13,0.839304176,2.529362443,1.338773782,0.002823806,0.001650392,"up","yes","Tuba3b","protein_coding","chr4:158075083-158083972:-","gi|195157178|ref|XP_002019473.1|",2271,0,"GL12416 [Drosophila persimilis]","gi|90962991|ref|NM_001040008.1|",1442,0,"Rattus norvegicus tubulin, alpha 3A (Tuba3a), mRNA","Q68FR8",867,0,"Tubulin alpha-3 chain","SPBC800.05c",699,0,"COG5023","pfam03953","Tubulin_C","Tubulin C-terminal domain. This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).",".","GO:0015630|microtubule cytoskeleton;","GO:0003924|GTPase activity;","K07374","TUBA; tubulin alpha"]
["ENSRNOG00000042296",13,0.836295696,2,0.129123719,6.476700802,2.695259099,0.002854285,0.00166667,"up","yes","Kpna7","protein_coding","chr12:9576378-9612833:+","gi|392352334|ref|XP_001074637.3|",2569,0,"PREDICTED: importin subunit alpha-8 [Rattus norvegicus]","gi|392352333|ref|XM_001074637.3|",1503,0,"PREDICTED: Rattus norvegicus karyopherin alpha 7 (Kpna7), mRNA","C0LLJ0",806,0,"Importin subunit alpha-8","SPBC1604.08c",339,{"v":8e-109,"d":"8.00E-109"},"COG5064","pfam01749","IBB","Importin beta binding domain. This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.","GO:0001824|blastocyst development;GO:0006607|NLS-bearing protein import into nucleus;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:1902466|positive regulation of histone H3-K27 trimethylation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005819|spindle;","GO:0008139|nuclear localization sequence binding;GO:0061608|nuclear import signal receptor activity;","K15043","KPNA2_7; importin subunit alpha-1/8"]
["ENSRNOG00000068402",13,0.836295696,2,0.129123719,6.476700802,2.695259099,0.002854285,0.00166667,"up","yes","ENSRNOG00000068402","lncRNA","chr2:211047043-211055815:-",".",".",".",".","gi|672044097|ref|XR_352002.2|",402,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102550474 (LOC102550474), ncRNA",".",".",".",".",".",".",".",".","pfam01366","PRTP","Herpesvirus processing and transport protein. The members of this family are associate with capsid intermediates during packaging of the virus.",".",".",".",".","."]
["ENSRNOG00000017198",9,0.578973944,0,0.03228093,17.93547914,4.164744382,0.002948557,1.714356E-3,"up","yes","Hif3a","protein_coding","chr1:77722471-77749758:-","gi|11968112|ref|NP_071973.1|",3144,0,"hypoxia-inducible factor 3-alpha [Rattus norvegicus]","gi|402745390|ref|NM_022528.2|",2014,0,"Rattus norvegicus hypoxia inducible factor 3, alpha subunit (Hif3a), mRNA","Q9JHS2",1218,0,"Hypoxia-inducible factor 3-alpha",".",".",".",".","pfam14598","PAS_11","PAS domain. This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).","GO:0001525|angiogenesis;GO:0001666|response to hypoxia;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006366|transcription by RNA polymerase II;GO:0006915|apoptotic process;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0071456|cellular response to hypoxia;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016607|nuclear speck;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0005515|protein binding;GO:0046983|protein dimerization activity;","K09096","HIF3A; hypoxia-inducible factor 3 alpha"]
["ENSRNOG00000028362",9,0.578973944,0,0.03228093,17.93547914,4.164744382,0.002948557,1.714356E-3,"up","yes","Unc80","protein_coding","chr9:68011728-68187659:+","gi|589924308|ref|XP_006975032.1|",15895,0,"PREDICTED: protein unc-80 homolog isoform X1 [Peromyscus maniculatus bairdii]","gi|755492569|ref|XM_006496086.2|",9348,0,"PREDICTED: Mus musculus unc-80 homolog (C. elegans) (Unc80), transcript variant X5, mRNA","Q8BLN6",3494,0,"Protein unc-80 homolog",".",".",".",".","pfam15449","Retinal","Retinal protein. This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.","GO:0055080|cation homeostasis;GO:0098655|cation transmembrane transport;","GO:0030424|axon;GO:0034703|cation channel complex;","GO:0005261|cation channel activity;","K24015","UNC80; protein unc-80"]
["ENSRNOG00000030840",9,0.578973944,0,0.03228093,17.93547914,4.164744382,0.002948557,1.714356E-3,"up","yes","Cadm2","protein_coding","chr11:4555159-5525400:-","gi|568997528|ref|XP_006523091.1|",2045,0,"PREDICTED: cell adhesion molecule 2 isoform X3 [Mus musculus]","gi|755554972|ref|XM_006523028.2|",2329,0,"PREDICTED: Mus musculus cell adhesion molecule 2 (Cadm2), transcript variant X3, mRNA","Q8BLQ9",792,0,"Cell adhesion molecule 2",".",".",".",".","pfam08205","C2-set_2","CD80-like C2-set immunoglobulin domain. These domains belong to the immunoglobulin superfamily.","GO:0007155|cell adhesion;GO:0007420|brain development;","GO:0005737|cytoplasm;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0032809|neuronal cell body membrane;GO:0045202|synapse;","GO:0005515|protein binding;","K06782","CADM2, IGSF4D, NECL3; cell adhesion molecule 2"]
["ENSRNOG00000046776",9,0.578973944,0,0.03228093,17.93547914,4.164744382,0.002948557,1.714356E-3,"up","yes","Msx3","protein_coding","chr1:194839041-194841969:-","gi|30704771|gb|AAH51983.1|",721,{"v":4e-86,"d":"4.00E-86"},"Msx3 protein, partial [Mus musculus]","gi|282154796|ref|NM_053712.1|",2310,0,"Rattus norvegicus msh homeobox 3 (Msx3), mRNA","P70354",267,{"v":3e-82,"d":"3.00E-82"},"Homeobox protein MSX-3",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008150|biological_process;GO:0035067|negative regulation of histone acetylation;GO:0048598|embryonic morphogenesis;","GO:0005575|cellular_component;GO:0005634|nucleus;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003674|molecular_function;","K09341","MSX; homeobox protein MSX"]
["ENSRNOG00000056183",9,0.578973944,0,0.03228093,17.93547914,4.164744382,0.002948557,1.714356E-3,"up","yes","AABR07030781.1","snoRNA","chr10:100770794-100770925:-",".",".",".",".","gi|298897740|emb|FQ227960.1|",98,{"v":1E-42,"d":"1.00E-42"},"Rattus norvegicus TL0AEA11YB07 mRNA sequence",".",".",".",".",".",".",".",".","pfam08995","NIP_1","Necrosis inducing protein-1. Necrosis inducing protein-1, a fungal avirulence protein produced by plants, consists of two parts containing beta-sheets of two and three anti-parallel strands, respectively. Five intramolecular disulfide bonds, stabilize these parts and their position with respect to each other, providing a high level of stability.",".",".",".",".","."]
["ENSRNOG00000062425",9,0.578973944,0,0.03228093,17.93547914,4.164744382,0.002948557,1.714356E-3,"up","yes","ENSRNOG00000062425","protein_coding","chr9:2926288-2935264:-","gi|564310981|ref|XP_006226724.1|",900,{"v":2E-116,"d":"2.00E-116"},"PREDICTED: disks large homolog 5-like isoform X1 [Rattus norvegicus]","gi|71043739|ref|NM_001025755.1|",1243,0,"Rattus norvegicus similar to RIKEN cDNA 1700001E04 (MGC116197), mRNA",".",".",".",".",".",".",".",".","pfam04822","Takusan","Takusan. This domain is named takusan, which is a Japanese word meaning 'many'. Members of this family regulate synaptic activity.",".",".",".",".","."]
["ENSRNOG00000066322",9,0.578973944,0,0.03228093,17.93547914,4.164744382,0.002948557,1.714356E-3,"up","yes","Olr159","protein_coding","chr1:158916975-158920576:+","gi|47576465|ref|NP_001000170.1|",1578,0,"olfactory receptor Olr159 [Rattus norvegicus]","gi|49615119|gb|AC113720.6|",1614,0,"Rattus norvegicus 1 BAC CH230-117B1 (Children's Hospital Oakland Research Institute) complete sequence","Q8NGI2",547,0,"Olfactory receptor 52N4",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.",".",".",".",".","."]
["ENSRNOG00000066556",9,0.578973944,0,0.03228093,17.93547914,4.164744382,0.002948557,1.714356E-3,"up","yes","Fgf23","protein_coding","chr4:159914272-159923821:+","gi|18543369|ref|NP_570110.1|",1202,{"v":8e-156,"d":"8.00E-156"},"fibroblast growth factor 23 precursor [Rattus norvegicus]","gi|471434825|ref|NM_022657.4|",944,0,"Mus musculus fibroblast growth factor 23 (Fgf23), mRNA","Q8VI82",467,{"v":3E-157,"d":"3.00E-157"},"Fibroblast growth factor 23",".",".",".",".","pfam00167","FGF","Fibroblast growth factor. Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide range of contexts. They are found in a wide range of organisms, from nematodes to humans. Most share an internal core region of high similarity, conserved residues in which are involved in binding with their receptors. On binding, they cause dimerization of their tyrosine kinase receptors leading to intracellular signalling. There are currently four known tyrosine kinase receptors for fibroblast growth factors. These receptors can each bind several different members of this family. Members of this family have a beta trefoil structure. Most have N-terminal signal peptides and are secreted. A few lack signal sequences but are secreted anyway; still others also lack the signal peptide but are found on the cell surface and within the extracellular matrix. A third group remain intracellular. They have central roles in development, regulating cell proliferation, migration and differentiation. On the other hand, they are important in tissue repair following injury in adult organisms.",".",".",".",".","."]
["ENSRNOG00000066817",9,0.578973944,0,0.03228093,17.93547914,4.164744382,0.002948557,1.714356E-3,"up","yes","ENSRNOG00000066817","lncRNA","chr4:153521057-153533698:-",".",".",".",".","gi|31581812|gb|AC135963.3|",90,{"v":1e-37,"d":"1.00E-37"},"Mus musculus BAC clone RP23-346N11 from chromosome 7, complete sequence",".",".",".",".",".",".",".",".","pfam15324","TALPID3","Hedgehog signalling target. TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.",".",".",".",".","."]
["ENSRNOG00000067297",9,0.578973944,0,0.03228093,17.93547914,4.164744382,0.002948557,1.714356E-3,"up","yes","ENSRNOG00000067297","lncRNA","chr14:75005623-75010326:+",".",".",".",".","gi|46395439|gb|AC141898.3|",392,0,"Mus musculus BAC clone RP23-155I18 from chromosome 5, complete sequence",".",".",".",".",".",".",".",".","pfam07990","NABP","Nucleic acid binding protein NABP. Many members of this family are putative nucleic acid binding proteins. One member of this family has been partially characterized and contains two putative phosphorylation sites and a possible dimerization / leucine zipper domain.",".",".",".",".","."]
["ENSRNOG00000068353",9,0.578973944,0,0.03228093,17.93547914,4.164744382,0.002948557,1.714356E-3,"up","yes","ENSRNOG00000068353","protein_coding","chr1:258030937-258037823:+","gi|975107385|ref|XP_015269135.1|",539,{"v":1e-68,"d":"1.00E-68"},"PREDICTED: transcription elongation factor SPT4 isoform X1 [Gekko japonicus]","gi|298894371|emb|FQ224188.1|",261,{"v":7e-133,"d":"7.00E-133"},"Rattus norvegicus TL0ACA74YF17 mRNA sequence","Q4R941",209,{"v":5e-69,"d":"5.00E-69"},"Transcription elongation factor SPT4","ECU08g1660",85.1,{"v":6e-21,"d":"6.00E-21"},"COG5204","pfam06093","Spt4","Spt4/RpoE2 zinc finger. This family consists of several eukaryotic transcription elongation Spt4 proteins as well as archaebacterial RpoE2. Three transcription-elongation factors Spt4, Spt5, and Spt6 are conserved among eukaryotes and are essential for transcription via the modulation of chromatin structure. Spt4 and Spt5 are tightly associated in a complex, while the physical association of the Spt4-Spt5 complex with Spt6 is considerably weaker. It has been demonstrated that Spt4, Spt5, and Spt6 play roles in transcription elongation in both yeast and humans including a role in activation by Tat. It is known that Spt4, Spt5, and Spt6 are general transcription-elongation factors, controlling transcription both positively and negatively in important regulatory and developmental roles. RpoE2 is one of 13 subunits in the archaeal RNA polymerase. These proteins contain a C4-type zinc finger, and the structure has been solved in. The structure reveals that Spt4-Spt5 binding is governed by an acid-dipole interaction between Spt5 and Spt4, and the complex binds to and travels along the elongating RNA polymerase. The Spt4-Spt5 complex is likely to be an ancient, core component of the transcription elongation machinery.",".",".",".",".","."]
["ENSRNOG00000006110",36,2.315895775,15,0.968427895,2.391397219,1.257853786,2.959265E-3,0.001720225,"up","yes","Jph1","protein_coding","chr5:2030281-2125284:+","gi|148682412|gb|EDL14359.1|",2958,0,"junctophilin 1, partial [Mus musculus]","gi|157820160|ref|NM_001106630.1|",2461,0,"Rattus norvegicus junctophilin 1 (Jph1), mRNA","Q9ET80",1094,0,"Junctophilin-1",".",".",".",".","pfam02493","MORN","MORN repeat. The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22).  #=GF CC   A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesised to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.","GO:0007517|muscle organ development;","GO:0005654|nucleoplasm;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0014701|junctional sarcoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0016529|sarcoplasmic reticulum;GO:0030018|Z disc;GO:0030314|junctional membrane complex;","GO:0008307|structural constituent of muscle;","K19530","JPH; junctophilin"]
["ENSRNOG00000015438",42,2.701878404,19,1.226675333,2.202602702,1.13920929,0.003000673,1.743061E-3,"up","yes","Cesl1","protein_coding","chr19:13796623-13912035:+","gi|140969642|ref|NP_579829.3|",2772,0,"carboxylesterase 1D precursor [Rattus norvegicus]","gi|140969641|ref|NM_133295.3|",1566,0,"Rattus norvegicus carboxylesterase 1D (Ces1d), mRNA","P16303",1069,0,"Carboxylesterase 1D","DR2626",224,{"v":2e-63,"d":"2.00E-63"},"COG2272","pfam00135","COesterase","Carboxylesterase family.","GO:0001523|retinoid metabolic process;GO:0016042|lipid catabolic process;GO:0042572|retinol metabolic process;","GO:0005783|endoplasmic reticulum;GO:0005788|endoplasmic reticulum lumen;GO:0005811|lipid droplet;GO:0005829|cytosol;GO:0043231|intracellular membrane-bounded organelle;","GO:0003723|RNA binding;GO:0016787|hydrolase activity;GO:0047376|all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity;GO:0052689|carboxylic ester hydrolase activity;GO:0080030|methyl indole-3-acetate esterase activity;","K01044","CES1; carboxylesterase 1 [EC:3.1.1.1]"]
["ENSRNOG00000050784",42,2.701878404,19,1.226675333,2.202602702,1.13920929,0.003000673,1.743061E-3,"up","yes","AABR07054000.1","protein_coding","chr3:127720181-129734492:+","gi|148227060|ref|NP_001013824.2|",1938,0,"O-acetyl-ADP-ribose deacetylase MACROD2 isoform 1 [Mus musculus]","gi|315604109|ref|NM_001013802.3|",1398,0,"Mus musculus MACRO domain containing 2 (Macrod2), transcript variant 1, mRNA","Q3UYG8",751,0,"O-acetyl-ADP-ribose deacetylase MACROD2","RSc0334",174,{"v":3e-50,"d":"3.00E-50"},"COG2110","pfam01661","Macro","Macro domain. This domain is an ADP-ribose binding module. It is found in a number of otherwise unrelated proteins. It is found at the C-terminus of the macro-H2A histone protein. This domain is found in the non-structural proteins of several types of ssRNA viruses such as NSP3 from alphaviruses. This domain is also found on its own in a family of proteins from bacteria, archaebacteria, and eukaryotes.",".",".",".",".","."]
["ENSRNOG00000033000",39,2.508887089,17,1.097551614,2.285894401,1.192758758,0.00301225,1.74943E-3,"up","yes","Oog1","protein_coding","chr5:155838197-155843863:+","gi|564306396|ref|XP_006225657.1|",2489,0,"PREDICTED: putative PRAME family member 24 [Rattus norvegicus]","gi|672020074|ref|XM_006225595.2|",1532,0,"PREDICTED: Rattus norvegicus oogenesin 1 (Oog1), mRNA","Q3UWY1",564,0,"Oogenesin-3",".",".",".",".","pfam01228","Gly_radical","Glycine radical.","GO:0008284|positive regulation of cell proliferation;GO:0043066|negative regulation of apoptotic process;GO:0045596|negative regulation of cell differentiation;GO:0045892|negative regulation of transcription, DNA-templated;","GO:0005737|cytoplasm;",".",".","."]
["ENSRNOG00000007137",15,0.964956573,3,0.193685579,4.98207754,2.316747476,0.003271709,0.001890887,"up","yes","Ly6i","protein_coding","chr7:107062325-107067310:-","gi|21245088|ref|NP_640350.1|",537,{"v":4e-65,"d":"4.00E-65"},"lymphocyte antigen 6B precursor [Rattus norvegicus]","gi|672059387|ref|XM_008765545.1|",898,0,"PREDICTED: Rattus norvegicus lymphocyte antigen 6 complex, locus I (Ly6i), transcript variant X3, mRNA","Q63317",211,{"v":1e-66,"d":"1.00E-66"},"Lymphocyte antigen 6B",".",".",".",".","pfam00021","UPAR_LY6","u-PAR/Ly-6 domain. This extracellular disulphide bond rich domain is related to pfam00087.","GO:0095500|acetylcholine receptor signaling pathway;GO:2000272|negative regulation of signaling receptor activity;","GO:0005886|plasma membrane;GO:0031225|anchored component of membrane;GO:0045202|synapse;","GO:0030550|acetylcholine receptor inhibitor activity;GO:0033130|acetylcholine receptor binding;","K06846","LY6D_E_F_G6_H; lymphocyte antigen 6 complex locus protein D/E/F/G6/H"]
["ENSRNOG00000009031",15,0.964956573,3,0.193685579,4.98207754,2.316747476,0.003271709,0.001890887,"up","yes","Gucy2c","protein_coding","chr4:169568529-169649092:-","gi|6981000|ref|NP_037302.1|",5665,0,"heat-stable enterotoxin receptor precursor [Rattus norvegicus]","gi|6980999|ref|NM_013170.1|",3770,0,"Rattus norvegicus guanylate cyclase 2C (Gucy2c), mRNA","P23897",2186,0,"Heat-stable enterotoxin receptor","all0661",169,{"v":2e-43,"d":"2.00E-43"},"COG2114","pfam00211","Guanylate_cyc","Adenylate and Guanylate cyclase catalytic domain.","GO:0006182|cGMP biosynthetic process;GO:0006468|protein phosphorylation;GO:0007165|signal transduction;GO:0007168|receptor guanylyl cyclase signaling pathway;GO:0009636|response to toxic substance;GO:0035556|intracellular signal transduction;GO:0042127|regulation of cell proliferation;","GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0001653|peptide receptor activity;GO:0004383|guanylate cyclase activity;GO:0004672|protein kinase activity;GO:0005524|ATP binding;GO:0005525|GTP binding;GO:0015643|toxic substance binding;GO:0016941|natriuretic peptide receptor activity;GO:0017046|peptide hormone binding;","K12320","GUCY2C; heat-stable enterotoxin receptor [EC:4.6.1.2]"]
["ENSRNOG00000061511",15,0.964956573,3,0.193685579,4.98207754,2.316747476,0.003271709,0.001890887,"up","yes","ENSRNOG00000061511","protein_coding","chrX:152340658-152341853:+","gi|564323885|ref|XP_006227268.1|",1023,{"v":2e-139,"d":"2.00E-139"},"PREDICTED: EKC/KEOPS complex subunit LAGE3-like [Rattus norvegicus]","gi|672088904|ref|XM_006229616.2|",597,0,"PREDICTED: Rattus norvegicus L antigen family member 3-like (LOC102552182), mRNA","Q9CR70",72.8,{"v":7e-15,"d":"7.00E-15"},"EKC/KEOPS complex subunit Lage3",".",".",".",".","pfam09341","Pcc1","Transcription factor Pcc1. Pcc1 is a transcription factor that functions in regulating genes involved in cell cycle progression and polarised growth.","GO:0070525|tRNA threonylcarbamoyladenosine metabolic process;","GO:0000408|EKC/KEOPS complex;",".",".","."]
["ENSRNOG00000068252",15,0.964956573,3,0.193685579,4.98207754,2.316747476,0.003271709,0.001890887,"up","yes","Olr1646","protein_coding","chr15:27729827-27736945:-","gi|47576567|ref|NP_001000103.1|",1426,{"v":3e-177,"d":"3.00E-177"},"olfactory receptor Olr1646 [Rattus norvegicus]","gi|218511252|gb|AC097037.8|",6375,0,"Rattus norvegicus CH230-20D8 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q9Z1V0",514,{"v":9e-165,"d":"9.00E-165"},"Olfactory receptor 49",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.",".",".",".",".","."]
["ENSRNOG00000066392",19,1.222278326,5,0.322809298,3.78637893,1.920818799,0.003290671,1.901268E-3,"up","yes","ENSRNOG00000066392","lncRNA","chr4:62593370-62597292:+",".",".",".",".","gi|62988373|gb|AC153817.6|",663,0,"Mus musculus BAC RP23-11P24 (Roswell Park Cancer Institute (C57BL/6J Female) Mouse BAC Library) complete sequence",".",".",".",".",".",".",".",".","pfam03849","Tfb2","Transcription factor Tfb2.",".",".",".",".","."]
["ENSRNOG00000065189",26,1.672591393,9,0.581056737,2.87853369,1.525334097,0.003455453,0.001991841,"up","yes","ENSRNOG00000065189","protein_coding","chr15:4589987-4599799:-","gi|564317541|ref|XP_006221948.1|",1022,{"v":3E-134,"d":"3.00E-134"},"PREDICTED: disks large homolog 5-like isoform X1 [Rattus norvegicus]","gi|672077738|ref|XM_008770593.1|",878,0,"PREDICTED: Rattus norvegicus disks large homolog 5-like (LOC102550466), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam04822","Takusan","Takusan. This domain is named takusan, which is a Japanese word meaning 'many'. Members of this family regulate synaptic activity.",".",".",".",".","."]
["ENSRNOG00000005726",37,2.380226213,16,1.032989754,2.304210862,1.204272746,0.003597007,2.070929E-3,"up","yes","Pclo","protein_coding","chr4:19695315-20049885:-","gi|10048483|ref|NP_064483.1|",18877,0,"protein piccolo isoform 1 [Rattus norvegicus]","gi|10048482|ref|NM_020098.1|",15599,0,"Rattus norvegicus piccolo (presynaptic cytomatrix protein) (Pclo), transcript variant 1, mRNA","Q9JKS6",7276,0,"Protein piccolo","YOR086c",58.9,5e-07,"COG5038","pfam05715","zf-piccolo","Piccolo Zn-finger. This (predicted) Zinc finger is found in the bassoon and piccolo proteins. There are eight conserved cysteines, suggesting that it coordinates two zinc ligands.","GO:0007010|cytoskeleton organization;GO:0007416|synapse assembly;GO:0016080|synaptic vesicle targeting;GO:0017157|regulation of exocytosis;GO:0030073|insulin secretion;GO:0035418|protein localization to synapse;GO:0048790|maintenance of presynaptic active zone structure;GO:0050808|synapse organization;GO:0051036|regulation of endosome size;GO:0097091|synaptic vesicle clustering;GO:0098815|modulation of excitatory postsynaptic potential;GO:0099526|presynapse to nucleus signaling pathway;GO:1903423|positive regulation of synaptic vesicle recycling;GO:1904071|presynaptic active zone assembly;GO:1904666|regulation of ubiquitin protein ligase activity;","GO:0005798|Golgi-associated vesicle;GO:0005802|trans-Golgi network;GO:0014069|postsynaptic density;GO:0030133|transport vesicle;GO:0030424|axon;GO:0030425|dendrite;GO:0030426|growth cone;GO:0031594|neuromuscular junction;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0044316|cone cell pedicle;GO:0044317|rod spherule;GO:0045202|synapse;GO:0048471|perinuclear region of cytoplasm;GO:0048786|presynaptic active zone;GO:0048788|cytoskeleton of presynaptic active zone;GO:0060077|inhibitory synapse;GO:0097470|ribbon synapse;GO:0098688|parallel fiber to Purkinje cell synapse;GO:0098831|presynaptic active zone cytoplasmic component;GO:0098978|glutamatergic synapse;GO:0098982|GABA-ergic synapse;","GO:0001222|transcription corepressor binding;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0005522|profilin binding;GO:0005544|calcium-dependent phospholipid binding;GO:0098882|structural constituent of presynaptic active zone;","K16882","PCLO; protein piccolo"]
["ENSRNOG00000027821",10,0.643304382,1,0.06456186,9.96415508,3.316747476,0.003842201,2.202992E-3,"up","yes","Lcn9","protein_coding","chr3:8636548-8652200:+","gi|672044786|ref|XP_008759844.1|",765,{"v":2e-96,"d":"2.00E-96"},"PREDICTED: epididymal-specific lipocalin-9 isoform X1 [Rattus norvegicus]","gi|108947877|gb|DQ537496.1|",427,0,"Rattus norvegicus lipocalin 9 (Lcn9) mRNA, complete cds","Q9D267",232,{"v":2e-72,"d":"2.00E-72"},"Epididymal-specific lipocalin-9",".",".",".",".","pfam00061","Lipocalin","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.",".","GO:0005615|extracellular space;","GO:0005550|pheromone binding;GO:0036094|small molecule binding;",".","."]
["ENSRNOG00000029591",10,0.643304382,1,0.06456186,9.96415508,3.316747476,0.003842201,2.202992E-3,"up","yes","Pkdrej","protein_coding","chr7:116909094-116915468:-","gi|198442901|ref|NP_001128338.1|",10759,0,"polycystic kidney disease and receptor for egg jelly-related protein precursor [Rattus norvegicus]","gi|198442900|ref|NM_001134866.1|",6375,0,"Rattus norvegicus polycystin (PKD) family receptor for egg jelly (Pkdrej), mRNA","Q9Z0T6",3396,0,"Polycystic kidney disease and receptor for egg jelly-related protein",".",".",".",".","pfam08016","PKD_channel","Polycystin cation channel. This family contains the cation channel region of PKD1 and PKD2 proteins.","GO:0050982|detection of mechanical stimulus;GO:0060046|regulation of acrosome reaction;GO:0070588|calcium ion transmembrane transport;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0005262|calcium channel activity;GO:0005509|calcium ion binding;","K19921","PKDREJ; polycystic kidney disease and receptor for egg jelly-related protein"]
["ENSRNOG00000050840",10,0.643304382,1,0.06456186,9.96415508,3.316747476,0.003842201,2.202992E-3,"up","yes","Mir155","miRNA","chr11:23774654-23774718:+",".",".",".",".","gi|827342590|ref|NR_132107.1|",65,{"v":8e-25,"d":"8.00E-25"},"Rattus norvegicus Mir155 host gene (Mir155hg), long non-coding RNA",".",".",".",".",".",".",".",".","pfam11872","DUF3392","Protein of unknown function (DUF3392). This family of proteins are functionally uncharacterized. This protein is found in bacteria. Proteins in this family are about 110 amino acids in length.","GO:0002437|inflammatory response to antigenic stimulus;GO:0010629|negative regulation of gene expression;GO:0030307|positive regulation of cell growth;GO:0032729|positive regulation of interferon-gamma production;GO:0035195|gene silencing by miRNA;GO:0060218|hematopoietic stem cell differentiation;GO:0070482|response to oxygen levels;GO:0071222|cellular response to lipopolysaccharide;GO:0071230|cellular response to amino acid stimulus;GO:0071354|cellular response to interleukin-6;GO:0071549|cellular response to dexamethasone stimulus;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0097011|cellular response to granulocyte macrophage colony-stimulating factor stimulus;",".",".","K17009","MIR155; microRNA 155"]
["ENSRNOG00000058033",10,0.643304382,1,0.06456186,9.96415508,3.316747476,0.003842201,2.202992E-3,"up","yes","Gm23202","snoRNA","chr12:8269905-8270033:-",".",".",".",".","gi|908662927|tpe|LN872378.1|",125,{"v":9e-58,"d":"9.00E-58"},"TPA: Mus musculus SNORA27 (ACA27) gene for small nucleolar RNA SNORA27 (ACA27)",".",".",".",".",".",".",".",".","pfam03142","Chitin_synth_2","Chitin synthase. Members of this family are fungal chitin synthase EC:2.4.1.16 enzymes. They catalyse chitin synthesis as follows: UDP-N-acetyl-D-glucosamine + {(1,4)-(N-acetyl-beta-D-glucosaminyl)}(N) <=> UDP + {(1,4)-(N-acetyl-beta-D-glucosaminyl)}(N+1).",".",".",".",".","."]
["ENSRNOG00000062839",10,0.643304382,1,0.06456186,9.96415508,3.316747476,0.003842201,2.202992E-3,"up","yes","ENSRNOG00000062839","protein_coding","chr19:29819856-29820542:-","gi|672031222|ref|XP_008772446.1|",777,{"v":1e-102,"d":"1.00E-102"},"PREDICTED: LOW QUALITY PROTEIN: AP-3 complex subunit sigma-1-like [Rattus norvegicus]","gi|672031221|ref|XM_008774224.1|",355,0,"PREDICTED: Rattus norvegicus similar to AP-3 complex subunit sigma-1 (Adapter-related protein complex 3 sigma-1 subunit) (Sigma-adaptin 3a) (AP-3 complex sigma-3A subunit) (Sigma-3A-adaptin) (LOC689488), mRNA","Q9DCR2",293,{"v":2E-100,"d":"2.00E-100"},"AP-3 complex subunit sigma-1","SPAC30D11.05",159,{"v":1e-48,"d":"1.00E-48"},"COG5030","pfam01217","Clat_adaptor_s","Clathrin adaptor complex small chain.",".",".",".",".","."]
["ENSRNOG00000064017",10,0.643304382,1,0.06456186,9.96415508,3.316747476,0.003842201,2.202992E-3,"up","yes","ENSRNOG00000064017","lncRNA","chr9:111386455-111398868:+","gi|293349986|ref|XP_001056555.2|",342,{"v":7e-31,"d":"7.00E-31"},"PREDICTED: structural maintenance of chromosomes flexible hinge domain-containing protein 1 isoform X1 [Rattus norvegicus]","gi|39930807|gb|AC107664.8|",542,0,"Mus musculus chromosome 17, clone RP23-103F2, complete sequence","Q6P5D8",115,{"v":7e-26,"d":"7.00E-26"},"Structural maintenance of chromosomes flexible hinge domain-containing protein 1",".",".",".",".","pfam03152","UFD1","Ubiquitin fusion degradation protein UFD1. Post-translational ubiquitin-protein conjugates are recognized for degradation by the ubiquitin fusion degradation (UFD) pathway. Several proteins involved in this pathway have been identified. This family includes UFD1, a 40kD protein that is essential for vegetative cell viability. The human UFD1 gene is expressed at high levels during embryogenesis, especially in the eyes and in the inner ear primordia and is thought to be important in the determination of ectoderm-derived structures, including neural crest cells. In addition, this gene is deleted in the CATCH-22 (cardiac defects, abnormal facies, thymic hypoplasia, cleft palate and hypocalcaemia with deletions on chromosome 22) syndrome. This clinical syndrome is associated with a variety of developmental defects, all characterized by microdeletions on 22q11.2. Two such developmental defects are the DiGeorge syndrome OMIM:188400, and the velo-cardio- facial syndrome OMIM:145410. Several of the abnormalities associated with these conditions are thought to be due to defective neural crest cell differentiation.",".",".",".",".","."]
["ENSRNOG00000066489",10,0.643304382,1,0.06456186,9.96415508,3.316747476,0.003842201,2.202992E-3,"up","yes","ENSRNOG00000066489","protein_coding","chr1:260287649-260304266:+","gi|564334560|ref|XP_006231754.1|",344,{"v":3e-36,"d":"3.00E-36"},"PREDICTED: zinc finger protein 431-like isoform X2 [Rattus norvegicus]","gi|672040970|ref|XM_006231692.2|",905,0,"PREDICTED: Rattus norvegicus zinc finger protein 120-like (LOC102550729), transcript variant X3, mRNA","E9QAG8",115,{"v":8e-27,"d":"8.00E-27"},"Zinc finger protein 431",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000066874",10,0.643304382,1,0.06456186,9.96415508,3.316747476,0.003842201,2.202992E-3,"up","yes","ENSRNOG00000066874","protein_coding","chr1:92898827-92899972:+","gi|40254752|ref|NP_445743.2|",1023,{"v":2e-135,"d":"2.00E-135"},"phosphoglycerate kinase 1 [Rattus norvegicus]","gi|298891607|emb|FQ215125.1|",420,0,"Rattus norvegicus TL0ACA49YL03 mRNA sequence","P16617",398,{"v":6e-137,"d":"6.00E-137"},"Phosphoglycerate kinase 1","SPBC14F5.04c",259,{"v":4e-83,"d":"4.00E-83"},"COG0126","pfam00162","PGK","Phosphoglycerate kinase.",".",".",".",".","."]
["ENSRNOG00000063019",29,1.865582707,11,0.710180456,2.626913612,1.393368757,3.899376E-3,0.002233532,"up","yes","ENSRNOG00000063019","protein_coding","chr1:78365496-78375824:-","gi|672013157|ref|XP_006223150.2|",450,{"v":2E-52,"d":"2.00E-52"},"PREDICTED: homeobox protein goosecoid-like [Rattus norvegicus]","gi|672013156|ref|XM_006223088.2|",316,{"v":6e-163,"d":"6.00E-163"},"PREDICTED: Rattus norvegicus paired box protein Pax-7-like (LOC102553890), mRNA",".",".",".",".",".",".",".",".","pfam00046","Homeobox","Homeobox domain.",".",".",".",".","."]
["ENSRNOG00000020720",24,1.543930516,8,0.516494877,2.989246524,1.579781881,0.003948314,0.002259976,"up","yes","Fbxw12","protein_coding","chr8:109786815-109801813:-","gi|672023340|ref|XP_001075538.3|",2307,0,"PREDICTED: F-box/WD repeat-containing protein 12 [Rattus norvegicus]","gi|672023339|ref|XM_001075538.3|",1291,0,"PREDICTED: Rattus norvegicus F-box and WD repeat domain containing 12 (Fbxw12), mRNA","L7N1X6",580,0,"F-box/WD repeat-containing protein 15",".",".",".",".","pfam12937","F-box-like","F-box-like. This is an F-box-like family.",".",".",".","K10267","FBXW12S; F-box and WD-40 domain protein 12/13/14/15/16/17/19"]
["ENSRNOG00000030104",32,2.058574022,13,0.839304176,2.452715097,1.294379663,0.004168226,0.002380127,"up","yes","Vom2r44","protein_coding","chr2:148500170-148531880:+","gi|564336661|ref|XP_006232500.1|",4745,0,"PREDICTED: vomeronasal type-2 receptor 1 isoform X1 [Rattus norvegicus]","gi|672042496|ref|XM_006232438.2|",2903,0,"PREDICTED: Rattus norvegicus vomeronasal 2 receptor 44 (Vom2r44), transcript variant X1, mRNA","O70410",1705,0,"Vomeronasal type-2 receptor 1",".",".",".",".","pfam00003","7tm_3","7 transmembrane sweet-taste receptor of 3 GCPR. This is a domain of seven transmembrane regions that forms the C-terminus of some subclass 3 G-coupled-protein receptors. It is often associated with a downstream cysteine-rich linker domain, NCD3G pfam07562, which is the human sweet-taste receptor, and the N-terminal domain, ANF_receptor pfam01094. The seven TM regions assemble in such a way as to produce a docking pocket into which such molecules as cyclamate and lactisole have been found to bind and consequently confer the taste of sweetness.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0050911|detection of chemical stimulus involved in sensory perception of smell;","GO:0005887|integral component of plasma membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004984|olfactory receptor activity;","K04613","V2R; vomeronasal 2 receptor"]
["ENSRNOG00000063781",41,2.637547966,19,1.226675333,2.15015978,1.104443872,0.00423877,0.002418232,"up","yes","ENSRNOG00000063781","protein_coding","chr5:127376764-127398397:+","gi|300797222|ref|NP_001178499.1|",1849,0,"ankyrin repeat domain-containing protein 13C [Rattus norvegicus]","gi|672053518|ref|XM_008763971.1|",1927,0,"PREDICTED: Rattus norvegicus ankyrin repeat domain-containing protein 13C-like (LOC102548397), transcript variant X2, mRNA","Q3UX43",701,0,"Ankyrin repeat domain-containing protein 13C",".",".",".",".","pfam11904","GPCR_chapero_1","GPCR-chaperone. This domain, and the associated ANK family repeat pfam00023 domain, together act as a chaperone for biogenesis and folding of the DP receptor for prostaglandin D2.",".",".",".",".","."]
["ENSRNOG00000002504",35,2.251565336,15,0.968427895,2.324969519,1.217211802,4.293804E-3,0.002447185,"up","yes","Spata17","protein_coding","chr13:98605986-98784929:-","gi|564316357|ref|XP_006221663.1|",1624,0,"PREDICTED: spermatogenesis-associated protein 17 [Rattus norvegicus]","gi|672027488|ref|XM_008763837.1|",1400,0,"PREDICTED: Rattus norvegicus spermatogenesis associated 17 (Spata17), transcript variant X1, mRNA","Q9D552",555,0,"Spermatogenesis-associated protein 17",".",".",".",".","pfam15279","SOBP","Sine oculis-binding protein. SOBP is associated with syndromic and nonsyndromic intellectual disability. It carries a zinc-finger of the zf-C2H2 type at the N-terminus, and a highly characteristic C-terminal PhPhPhPhPhPh motif. The deduced 873-amino acid protein contains an N-terminal nuclear localisation signal (NLS), followed by 2 FCS-type zinc finger motifs, a proline-rich region (PR1), a putative RNA-binding motif region, and a C-terminal NLS embedded in a second proline-rich motif. SOBP is expressed in various human tissues, including developing mouse brain at embryonic day 14. In postnatal and adult mouse brain SOBP is expressed in all neurons, with intense staining in the limbic system. Highest expression is in layer V cortical neurons, hippocampus, pyriform cortex, dorsomedial nucleus of thalamus, amygdala, and hypothalamus. Postnatal expression of SOBP in the limbic system corresponds to a time of active synaptogenesis. the family is also referred to as Jackson circler, JXC1. In seven affected siblings from a consanguineous Israeli Arab family with mental retardation, anterior maxillary protrusion, and strabismus mutations were found in this protein.",".",".","GO:0005516|calmodulin binding;","K25546","SPATA17; spermatogenesis-associated protein 17"]
["ENSRNOG00000031773",35,2.251565336,15,0.968427895,2.324969519,1.217211802,4.293804E-3,0.002447185,"up","yes","Cngb1","protein_coding","chr19:9726595-9791173:+","gi|149032406|gb|EDL87297.1|",3402,0,"rCG39000, isoform CRA_c [Rattus norvegicus]","gi|13929147|ref|NM_031809.1|",3840,0,"Rattus norvegicus cyclic nucleotide gated channel beta 1 (Cngb1), mRNA","Q28181",1143,0,"Cyclic nucleotide-gated cation channel beta-1",".",".",".",".","pfam00027","cNMP_binding","Cyclic nucleotide-binding domain.","GO:0001895|retina homeostasis;GO:0006812|cation transport;GO:0007601|visual perception;GO:0007602|phototransduction;GO:0007608|sensory perception of smell;GO:0010628|positive regulation of gene expression;GO:0021630|olfactory nerve maturation;GO:0033365|protein localization to organelle;GO:0035845|photoreceptor cell outer segment organization;GO:0045494|photoreceptor cell maintenance;GO:0050908|detection of light stimulus involved in visual perception;GO:0050911|detection of chemical stimulus involved in sensory perception of smell;GO:0051480|regulation of cytosolic calcium ion concentration;GO:0051899|membrane depolarization;GO:0098655|cation transmembrane transport;GO:0099105|ion channel modulating, G protein-coupled receptor signaling pathway;GO:1990834|response to odorant;","GO:0001750|photoreceptor outer segment;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0017071|intracellular cyclic nucleotide activated cation channel complex;GO:0043195|terminal bouton;GO:1902495|transmembrane transporter complex;","GO:0005221|intracellular cyclic nucleotide activated cation channel activity;GO:0005222|intracellular cAMP-activated cation channel activity;GO:0005223|intracellular cGMP-activated cation channel activity;GO:0030553|cGMP binding;GO:0043855|cyclic nucleotide-gated ion channel activity;GO:0044877|protein-containing complex binding;","K04952","CNGB1; cyclic nucleotide gated channel beta 1"]
["ENSRNOG00000016648",38,2.444556651,17,1.097551614,2.227281724,1.155284053,0.004307964,0.002454521,"up","yes","Gulo","protein_coding","chr15:40205665-40227874:-","gi|60097943|ref|NP_071556.2|",2246,0,"L-gulonolactone oxidase [Rattus norvegicus]","gi|298913904|emb|FQ219632.1|",2276,0,"Rattus norvegicus TL0ABA43YP11 mRNA sequence","P10867",867,0,"L-gulonolactone oxidase","Rv1771",241,{"v":3e-70,"d":"3.00E-70"},"COG0277","pfam04030","ALO","D-arabinono-1,4-lactone oxidase. This domain is specific to D-arabinono-1,4-lactone oxidase EC:1.1.3.-, which is involved in the final step of the D-erythroascorbic acid biosynthesis pathway.","GO:0019853|L-ascorbic acid biosynthetic process;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0003885|D-arabinono-1,4-lactone oxidase activity;GO:0016491|oxidoreductase activity;GO:0050105|L-gulonolactone oxidase activity;GO:0050660|flavin adenine dinucleotide binding;GO:0071949|FAD binding;","K00103","GULO; L-gulonolactone oxidase [EC:1.1.3.8]"]
["ENSRNOG00000021984",22,1.41526964,7,0.451933018,3.131591597,1.646896077,0.004461722,0.002537823,"up","yes","Rgs7","protein_coding","chr13:86979279-87408888:-","gi|149040811|gb|EDL94768.1|",2339,0,"regulator of G-protein signaling 7, isoform CRA_b [Rattus norvegicus]","gi|9507046|ref|NM_019343.1|",1414,0,"Rattus norvegicus regulator of G-protein signaling 7 (Rgs7), mRNA","P49803",903,0,"Regulator of G-protein signaling 7",".",".",".",".","pfam00615","RGS","Regulator of G protein signaling domain. RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.","GO:0001975|response to amphetamine;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007420|brain development;GO:0008277|regulation of G protein-coupled receptor signaling pathway;GO:0009409|response to cold;GO:0009968|negative regulation of signal transduction;GO:0035556|intracellular signal transduction;GO:0043547|positive regulation of GTPase activity;GO:0045471|response to ethanol;GO:0060078|regulation of postsynaptic membrane potential;GO:1901381|positive regulation of potassium ion transmembrane transport;","GO:0005634|nucleus;GO:0005635|nuclear envelope;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0032991|protein-containing complex;GO:0044292|dendrite terminus;GO:0045121|membrane raft;GO:0045211|postsynaptic membrane;GO:0098793|presynapse;GO:0098978|glutamatergic synapse;","GO:0001965|G-protein alpha-subunit binding;GO:0005096|GTPase activator activity;GO:0005515|protein binding;GO:0031681|G-protein beta-subunit binding;","K16449","RGS; regulator of G-protein signaling"]
["ENSRNOG00000049615",45,2.894869718,22,1.420360912,2.03812263,1.027240858,0.004740179,2.686576E-3,"up","yes","Fam228b","protein_coding","chr6:27754506-27786537:-","gi|672020486|ref|XP_008774422.1|",1649,0,"PREDICTED: protein FAM228B isoform X1 [Rattus norvegicus]","gi|672055674|ref|XM_008764562.1|",1234,0,"PREDICTED: Rattus norvegicus family with sequence similarity 228, member B (Fam228b), transcript variant X7, mRNA",".",".",".",".",".",".",".",".","pfam02487","CLN3","CLN3 protein. This is a family of proteins from the CLN3 gene. A missense mutation of glutamic acid (E) to lysine (K) at position 295 in the human protein has been implicated in Juvenile neuronal ceroid lipofuscinosis (Batten disease).",".",".",".",".","."]
["ENSRNOG00000043300",30,1.929913146,12,0.774742316,2.49103877,1.316747476,0.004935962,0.002794766,"up","yes","Enho","protein_coding","chr5:56800980-56802777:-","gi|26341256|dbj|BAC34290.1|",391,{"v":5e-43,"d":"5.00E-43"},"unnamed protein product [Mus musculus]","gi|537361057|ref|NM_001282336.1|",952,0,"Rattus norvegicus energy homeostasis associated (Enho), mRNA","Q8K1D8",65.9,{"v":2E-12,"d":"2.00E-12"},"Adropin",".",".",".",".","pfam15548","DUF4655","Domain of unknown function (DUF4655). This family of proteins is found in eukaryotes. Proteins in this family are typically between 533 and 570 amino acids in length.","GO:0007165|signal transduction;GO:0045747|positive regulation of Notch signaling pathway;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0005179|hormone activity;","K25411","ENHO; adropin"]
["ENSRNOG00000047100",20,1.286608764,6,0.387371158,3.321385027,1.731784975,0.004964724,0.002808267,"up","yes","ENSRNOG00000047100","protein_coding","chrX:116800208-116805516:-","gi|120586989|ref|NP_001073365.1|",864,{"v":3e-111,"d":"3.00E-111"},"uncharacterized protein LOC367975 [Rattus norvegicus]","gi|120586988|ref|NM_001079896.1|",1406,0,"Rattus norvegicus similar to B-cell translocation gene 1 (LOC367975), mRNA","Q63073",306,{"v":2E-100,"d":"2.00E-100"},"Protein BTG1",".",".",".",".","pfam07742","BTG","BTG family.","GO:0008285|negative regulation of cell proliferation;GO:0045930|negative regulation of mitotic cell cycle;","GO:0005634|nucleus;GO:0005737|cytoplasm;",".","K14443","TOB; protein Tob/BTG"]
["ENSRNOG00000068552",33,2.12290446,14,0.903866035,2.348693697,1.231858578,0.00512309,0.002893261,"up","yes","ENSRNOG00000068552","lncRNA","chr4:105288091-105294156:-",".",".",".",".","gi|672018450|ref|XR_600719.1|",849,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103692155 (LOC103692155), ncRNA",".",".",".",".",".",".",".",".","pfam01941","AdoMet_Synthase","S-adenosylmethionine synthetase (AdoMet synthetase). This family consists of several archaebacterial S-adenosylmethionine synthetase C(AdoMet synthetase or MAT) (EC 2.5.1.6). S-Adenosylmethionine (AdoMet) occupies a central role in the metabolizm of all cells. The biological roles of AdoMet include acting as the primary methyl group donor, as a precursor to the polyamines, and as a progenitor of a 5'-deoxyadenosyl radical. S-Adenosylmethionine synthetase catalyses the only known route of AdoMet biosynthesis. The synthetic process occurs in a unique reaction in which the complete triphosphate chain is displaced from ATP and a sulfonium ion formed. MATs from various organisms contain ~400-amino acid polypeptide chains.",".",".",".",".","."]
["ENSRNOG00000032740",12,0.771965258,2,0.129123719,5.978493048,2.579781881,0.005131868,0.0028965,"up","yes","Tmem258b","protein_coding","chr9:56450406-56450645:+","gi|52346184|ref|NP_001005138.1|",311,{"v":3e-35,"d":"3.00E-35"},"transmembrane protein 258 [Xenopus tropicalis]","gi|672024011|ref|XM_002727225.4|",240,{"v":2E-121,"d":"2.00E-121"},"PREDICTED: Rattus norvegicus transmembrane protein 258 B (Tmem258b), mRNA","Q6DDB3",124,{"v":1e-36,"d":"1.00E-36"},"Transmembrane protein 258",".",".",".",".","pfam05251","UPF0197","Uncharacterized protein family (UPF0197). This family of proteins is functionally uncharacterized.","GO:0006487|protein N-linked glycosylation;","GO:0016021|integral component of membrane;GO:0032991|protein-containing complex;GO:0034998|oligosaccharyltransferase I complex;GO:0043227|membrane-bounded organelle;",".",".","."]
["ENSRNOG00000055965",12,0.771965258,2,0.129123719,5.978493048,2.579781881,0.005131868,0.0028965,"up","yes","U6","snRNA","chr2:174157426-174157535:-",".",".",".",".","gi|937346970|ref|NG_044746.1|",46,{"v":6e-14,"d":"6.00E-14"},"Homo sapiens RNA, U6 small nuclear 869, pseudogene (RNU6-869P) on chromosome 8",".",".",".",".",".",".",".",".","pfam08298","AAA_PrkA","PrkA AAA domain. This is a family of PrkA bacterial and archaeal serine kinases approximately 630 residues long. This is the N-terminal AAA domain.",".",".",".",".","."]
["ENSRNOG00000064252",12,0.771965258,2,0.129123719,5.978493048,2.579781881,0.005131868,0.0028965,"up","yes","ENSRNOG00000064252","lncRNA","chr2:82453554-82455282:+",".",".",".",".","gi|672015550|ref|XR_344219.2|",1122,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102553736 (LOC102553736), ncRNA",".",".",".",".",".",".",".",".","pfam14637","FNIP_M","Folliculin-interacting protein middle domain. This is the middle domain of folliculin-interacting proteins.",".",".",".",".","."]
["ENSRNOG00000065740",12,0.771965258,2,0.129123719,5.978493048,2.579781881,0.005131868,0.0028965,"up","yes","Myh2","protein_coding","chr10:51856738-51883236:+","gi|205830436|ref|NP_001128629.1|",9186,0,"myosin heavy chain IIa [Rattus norvegicus]","gi|205830435|ref|NM_001135157.1|",6041,0,"Rattus norvegicus myosin, heavy chain 2, skeletal muscle, adult (Myh2), mRNA","Q076A7",3490,0,"Myosin-2","SPCC645.05c",749,0,"COG5022","pfam01576","Myosin_tail_1","Myosin tail. The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.",".",".",".",".","."]
["ENSRNOG00000068444",12,0.771965258,2,0.129123719,5.978493048,2.579781881,0.005131868,0.0028965,"up","yes","Kcnj10","protein_coding","chr13:84802009-84835461:+","gi|564381811|ref|XP_006250347.1|",1942,0,"PREDICTED: ATP-sensitive inward rectifier potassium channel 10 isoform X2 [Rattus norvegicus]","gi|672074769|ref|XM_006250285.2|",2066,0,"PREDICTED: Rattus norvegicus potassium inwardly-rectifying channel, subfamily J, member 10 (Kcnj10), transcript variant X1, mRNA","P49655",747,0,"ATP-sensitive inward rectifier potassium channel 10",".",".",".",".","pfam01007","IRK","Inward rectifier potassium channel.",".",".",".",".","."]
["ENSRNOG00000053366",25,1.608260955,9,0.581056737,2.767820856,1.468750569,0.005302201,2.984675E-3,"up","yes","AABR07002784.1","protein_coding","chr1:83309355-83330251:-","gi|672013294|ref|XP_008772690.1|",3668,0,"PREDICTED: zinc finger protein 60-like isoform X1 [Rattus norvegicus]","gi|672013293|ref|XM_008774468.1|",2864,0,"PREDICTED: Rattus norvegicus zinc finger protein 59 (Zfp59), transcript variant X1, mRNA","P16374",786,0,"Zinc finger protein 60","SPAC144.09c",99.4,{"v":3e-21,"d":"3.00E-21"},"COG5048","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000055020",25,1.608260955,9,0.581056737,2.767820856,1.468750569,0.005302201,2.984675E-3,"up","yes","ENSRNOG00000055020","pseudogene","chr1:39601959-39603122:-","gi|507640871|ref|XP_004701506.1|",986,{"v":8e-129,"d":"8.00E-129"},"PREDICTED: heterogeneous nuclear ribonucleoprotein A3 isoform X3 [Echinops telfairi]","gi|34333453|gb|AY363226.1|",1125,0,"Rattus norvegicus heterogeneous nuclear ribonucleoprotein A3 variant a mRNA, complete cds; alternatively spliced","P51991",371,{"v":2e-124,"d":"2.00E-124"},"Heterogeneous nuclear ribonucleoprotein A3",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.",".",".",".",".","."]
["ENSRNOG00000015527",18,1.157947887,5,0.322809298,3.587095829,1.842816287,0.005402878,0.003038353,"up","yes","ENSRNOG00000015527","protein_coding","chr1:70426161-70457919:-","gi|293343720|ref|XP_001070253.2|",4636,0,"PREDICTED: NACHT, LRR and PYD domains-containing protein 4B-like [Rattus norvegicus]","gi|672013086|ref|XM_001070253.3|",2107,0,"PREDICTED: Rattus norvegicus NLR family, pyrin domain containing 4B (Nlrp4b), mRNA","Q8C6J9",1177,0,"NACHT, LRR and PYD domains-containing protein 4B",".",".",".",".","pfam05729","NACHT","NACHT domain. This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.",".",".",".","K22265","NLRP4; NACHT, LRR and PYD domains-containing protein 4"]
["ENSRNOG00000033136",18,1.157947887,5,0.322809298,3.587095829,1.842816287,0.005402878,0.003038353,"up","yes","RT1-M5","protein_coding","chr20:1546511-1548775:-","gi|270133009|ref|NP_001161825.1|",1854,0,"RT1 class Ib, locus M5 isoform 1 precursor [Rattus norvegicus]","gi|270133008|ref|NM_001168353.1|",1074,0,"Rattus norvegicus RT1 class Ib, locus M5 (RT1-M5), transcript variant 1, mRNA","P13749",419,{"v":5e-144,"d":"5.00E-144"},"Patr class I histocompatibility antigen, A-126 alpha chain",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.","GO:0001916|positive regulation of T cell mediated cytotoxicity;GO:0002476|antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002486|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0006955|immune response;","GO:0005615|extracellular space;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0005102|signaling receptor binding;GO:0042605|peptide antigen binding;","K06751","MHC1; MHC class I antigen"]
["ENSRNOG00000063221",18,1.157947887,5,0.322809298,3.587095829,1.842816287,0.005402878,0.003038353,"up","yes","Ncoa4","protein_coding","chr16:7366542-7409641:+","gi|564387996|ref|XP_006252722.1|",3153,0,"PREDICTED: nuclear receptor coactivator 4 isoform X1 [Rattus norvegicus]","gi|77628144|ref|NM_001034008.1|",3325,0,"Rattus norvegicus nuclear receptor coactivator 4 (Ncoa4), transcript variant 2, mRNA","Q13772",903,0,"Nuclear receptor coactivator 4",".",".",".",".","pfam12489","ARA70","Nuclear coactivator. This domain family is found in eukaryotes, and is typically between 127 and 138 amino acids in length. This family is ARA70, a nuclear coactivator which interacts with peroxisome proliferator-activated receptor gamma (PPARgamma) to regulate transcription and the addition of the PPARgamma ligand (prostaglandin J2) enhances this interaction.",".",".",".",".","."]
["ENSRNOG00000015877",8,0.514643505,0,0.03228093,15.94264813,3.994819381,0.00562286,3.141338E-3,"up","yes","Figla","protein_coding","chr4:118432765-118436690:+","gi|62647725|ref|XP_575589.1|",1023,{"v":2e-139,"d":"2.00E-139"},"PREDICTED: factor in the germline alpha isoform X2 [Rattus norvegicus]","gi|672050339|ref|XM_575589.5|",588,0,"PREDICTED: Rattus norvegicus folliculogenesis specific basic helix-loop-helix (Figla), mRNA","O55208",356,{"v":3E-124,"d":"3.00E-124"},"Factor in the germline alpha",".",".",".",".","pfam00010","HLH","Helix-loop-helix DNA-binding domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0032502|developmental process;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005667|transcription factor complex;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0043565|sequence-specific DNA binding;GO:0046983|protein dimerization activity;GO:1990837|sequence-specific double-stranded DNA binding;","K09066","FIGLA; factor in the germline alpha"]
["ENSRNOG00000027801",8,0.514643505,0,0.03228093,15.94264813,3.994819381,0.00562286,3.141338E-3,"up","yes","Zpbp","protein_coding","chr14:85833548-86033095:-","gi|564384926|ref|XP_006251567.1|",1820,0,"PREDICTED: zona pellucida-binding protein 1 isoform X1 [Rattus norvegicus]","gi|672076903|ref|XM_006251505.2|",1438,0,"PREDICTED: Rattus norvegicus zona pellucida binding protein (Zpbp), transcript variant X1, mRNA","Q62522",629,0,"Zona pellucida-binding protein 1",".",".",".",".","pfam07354","Sp38","Zona-pellucida-binding protein (Sp38). This family contains a number of zona-pellucida-binding proteins that seem to be restricted to mammals. These are sperm proteins that bind to the 90-kDa family of zona pellucida glycoproteins in a calcium-dependent manner. These represent some of the specific molecules that mediate the first steps of gamete interaction, allowing fertilisation to occur.","GO:0001675|acrosome assembly;GO:0007339|binding of sperm to zona pellucida;","GO:0001669|acrosomal vesicle;GO:0002199|zona pellucida receptor complex;GO:0005576|extracellular region;GO:0016021|integral component of membrane;GO:0044297|cell body;",".",".","."]
["ENSRNOG00000027836",8,0.514643505,0,0.03228093,15.94264813,3.994819381,0.00562286,3.141338E-3,"up","yes","Kcnmb3","protein_coding","chr2:115253761-115270142:-","gi|157151708|ref|NP_001098030.1|",1185,{"v":8e-158,"d":"8.00E-158"},"calcium-activated potassium channel subunit beta-3 [Rattus norvegicus]","gi|402744437|ref|NM_001104560.2|",1637,0,"Rattus norvegicus potassium calcium-activated channel subfamily M regulatory beta subunit 3 (Kcnmb3), mRNA","A7VL23",461,{"v":3e-159,"d":"3.00E-159"},"Calcium-activated potassium channel subunit beta-3",".",".",".",".","pfam03185","CaKB","Calcium-activated potassium channel, beta subunit.","GO:0001508|action potential;GO:0005513|detection of calcium ion;GO:0006813|potassium ion transport;GO:0019228|neuronal action potential;GO:0071805|potassium ion transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0008076|voltage-gated potassium channel complex;","GO:0015269|calcium-activated potassium channel activity;GO:0015459|potassium channel regulator activity;","K04939","KCNMB3; potassium large conductance calcium-activated channel subfamily M beta member 3"]
["ENSRNOG00000035516",8,0.514643505,0,0.03228093,15.94264813,3.994819381,0.00562286,3.141338E-3,"up","yes","Mir132","miRNA","chr10:60023696-60023796:+","gi|635086817|ref|XP_008008006.1|",159,{"v":2E-12,"d":"2.00E-12"},"PREDICTED: transcription initiation factor TFIID subunit 4-like, partial [Chlorocebus sabaeus]","gi|731442366|ref|NR_129072.1|",101,{"v":1e-44,"d":"1.00E-44"},"Eptesicus fuscus microRNA mir-132 (MIR132), microRNA",".",".",".",".",".",".",".",".","pfam11456","DUF3019","Protein of unknown function (DUF3019). This is a bacterial family of uncharacterized proteins.","GO:0007569|cell aging;GO:0014041|regulation of neuron maturation;GO:0050773|regulation of dendrite development;GO:0060291|long-term synaptic potentiation;GO:0070482|response to oxygen levels;GO:0071241|cellular response to inorganic substance;GO:1904322|cellular response to forskolin;","GO:0014069|postsynaptic density;",".",".","."]
["ENSRNOG00000063491",8,0.514643505,0,0.03228093,15.94264813,3.994819381,0.00562286,3.141338E-3,"up","yes","ENSRNOG00000063491","protein_coding","chr16:35225583-35226806:+","gi|62132952|gb|AAH92212.1|",591,{"v":4e-72,"d":"4.00E-72"},"Lonp1 protein, partial [Mus musculus]","gi|19173765|ref|NM_133404.1|",339,{"v":4E-176,"d":"4.00E-176"},"Rattus norvegicus lon peptidase 1, mitochondrial (Lonp1), mRNA","Q924S5",237,{"v":7E-72,"d":"7.00E-72"},"Lon protease homolog, mitochondrial","CT344",141,{"v":3e-38,"d":"3.00E-38"},"COG0466","pfam05362","Lon_C","Lon protease (S16) C-terminal proteolytic domain. The Lon serine proteases must hydrolyse ATP to degrade protein substrates. In Escherichia coli, these proteases are involved in turnover of intracellular proteins, including abnormal proteins following heat-shock. The active site for protease activity resides in a C-terminal domain. The Lon proteases are classified as family S16 in Merops.",".",".",".",".","."]
["ENSRNOG00000065831",8,0.514643505,0,0.03228093,15.94264813,3.994819381,0.00562286,3.141338E-3,"up","yes","Olr162","protein_coding","chr1:158954795-158958503:+","gi|47576529|ref|NP_001000950.1|",1430,0,"olfactory receptor Olr162 [Rattus norvegicus]","gi|90855788|gb|AC128039.4|",1753,0,"Rattus norvegicus BAC CH230-394A24 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q8NGI1",442,{"v":5e-148,"d":"5.00E-148"},"Putative olfactory receptor 56B2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.",".",".",".",".","."]
["ENSRNOG00000066826",8,0.514643505,0,0.03228093,15.94264813,3.994819381,0.00562286,3.141338E-3,"up","yes","ENSRNOG00000066826","protein_coding","chr2:45405314-45405970:-","gi|114052555|ref|NP_001040560.1|",375,{"v":9e-43,"d":"9.00E-43"},"nucleolar protein 16 [Rattus norvegicus]","gi|675644374|ref|XM_002744520.3|",155,{"v":7e-74,"d":"7.00E-74"},"PREDICTED: Callithrix jacchus NOP16 nucleolar protein (NOP16), mRNA","Q1RP77",149,{"v":3e-44,"d":"3.00E-44"},"Nucleolar protein 16",".",".",".",".","pfam09420","Nop16","Ribosome biogenesis protein Nop16. Nop16 is a protein involved in ribosome biogenesis.",".",".",".",".","."]
["ENSRNOG00000005542",14,0.900626135,3,0.193685579,4.649939037,2.217211802,5.666188E-3,0.003163278,"up","yes","Apob","protein_coding","chr6:30844368-30892497:+","gi|161783809|ref|NP_062160.2|",23667,0,"apolipoprotein B-100 precursor [Rattus norvegicus]","gi|161783808|ref|NM_019287.2|",13871,0,"Rattus norvegicus apolipoprotein B (Apob), mRNA","Q7TMA5",8973,0,"Apolipoprotein B-100",".",".",".",".","pfam01347","Vitellogenin_N","Lipoprotein amino terminal region. This family contains regions from: Vitellogenin, Microsomal triglyceride transfer protein and apolipoprotein B-100. These proteins are all involved in lipid transport. This family contains the LV1n chain from lipovitellin, that contains two structural domains.","GO:0001701|in utero embryonic development;GO:0006629|lipid metabolic process;GO:0006642|triglyceride mobilization;GO:0006869|lipid transport;GO:0007283|spermatogenesis;GO:0007399|nervous system development;GO:0008203|cholesterol metabolic process;GO:0009566|fertilization;GO:0009615|response to virus;GO:0009743|response to carbohydrate;GO:0009791|post-embryonic development;GO:0010033|response to organic substance;GO:0010269|response to selenium ion;GO:0010628|positive regulation of gene expression;GO:0010744|positive regulation of macrophage derived foam cell differentiation;GO:0010884|positive regulation of lipid storage;GO:0010886|positive regulation of cholesterol storage;GO:0016042|lipid catabolic process;GO:0019433|triglyceride catabolic process;GO:0030301|cholesterol transport;GO:0030317|flagellated sperm motility;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0033344|cholesterol efflux;GO:0034374|low-density lipoprotein particle remodeling;GO:0034383|low-density lipoprotein particle clearance;GO:0042157|lipoprotein metabolic process;GO:0042158|lipoprotein biosynthetic process;GO:0042159|lipoprotein catabolic process;GO:0042632|cholesterol homeostasis;GO:0042953|lipoprotein transport;GO:0045540|regulation of cholesterol biosynthetic process;GO:0048844|artery morphogenesis;GO:0071356|cellular response to tumor necrosis factor;GO:0071379|cellular response to prostaglandin stimulus;GO:0120009|intermembrane lipid transfer;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005811|lipid droplet;GO:0005829|cytosol;GO:0012506|vesicle membrane;GO:0031983|vesicle lumen;GO:0034359|mature chylomicron;GO:0034361|very-low-density lipoprotein particle;GO:0034362|low-density lipoprotein particle;GO:0034363|intermediate-density lipoprotein particle;GO:0034364|high-density lipoprotein particle;GO:0042627|chylomicron;GO:0043025|neuronal cell body;GO:0043231|intracellular membrane-bounded organelle;GO:0070971|endoplasmic reticulum exit site;","GO:0005319|lipid transporter activity;GO:0005515|protein binding;GO:0005543|phospholipid binding;GO:0008201|heparin binding;GO:0035473|lipase binding;GO:0050750|low-density lipoprotein particle receptor binding;GO:0120020|intermembrane cholesterol transfer activity;","K14462","APOB; apolipoprotein B"]
["ENSRNOG00000013953",14,0.900626135,3,0.193685579,4.649939037,2.217211802,5.666188E-3,0.003163278,"up","yes","Ntrk1","protein_coding","chr2:173236963-173253770:-","gi|11024666|ref|NP_067600.1|",3923,0,"high affinity nerve growth factor receptor precursor [Rattus norvegicus]","gi|11024665|ref|NM_021589.1|",2617,0,"Rattus norvegicus neurotrophic tyrosine kinase, receptor, type 1 (Ntrk1), mRNA","P35739",1515,0,"High affinity nerve growth factor receptor",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001934|positive regulation of protein phosphorylation;GO:0006468|protein phosphorylation;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007178|transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0007275|multicellular organism development;GO:0007399|nervous system development;GO:0007411|axon guidance;GO:0007568|aging;GO:0007611|learning or memory;GO:0007623|circadian rhythm;GO:0008285|negative regulation of cell proliferation;GO:0009314|response to radiation;GO:0009410|response to xenobiotic stimulus;GO:0010623|programmed cell death involved in cell development;GO:0010976|positive regulation of neuron projection development;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0014823|response to activity;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0019233|sensory perception of pain;GO:0021553|olfactory nerve development;GO:0030183|B cell differentiation;GO:0031175|neuron projection development;GO:0031667|response to nutrient levels;GO:0033674|positive regulation of kinase activity;GO:0035094|response to nicotine;GO:0038083|peptidyl-tyrosine autophosphorylation;GO:0038179|neurotrophin signaling pathway;GO:0038180|nerve growth factor signaling pathway;GO:0042490|mechanoreceptor differentiation;GO:0043068|positive regulation of programmed cell death;GO:0043410|positive regulation of MAPK cascade;GO:0043524|negative regulation of neuron apoptotic process;GO:0043547|positive regulation of GTPase activity;GO:0045471|response to ethanol;GO:0045766|positive regulation of angiogenesis;GO:0046579|positive regulation of Ras protein signal transduction;GO:0046777|protein autophosphorylation;GO:0048011|neurotrophin TRK receptor signaling pathway;GO:0048013|ephrin receptor signaling pathway;GO:0048485|sympathetic nervous system development;GO:0048666|neuron development;GO:0048678|response to axon injury;GO:0050965|detection of temperature stimulus involved in sensory perception of pain;GO:0050966|detection of mechanical stimulus involved in sensory perception of pain;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051599|response to hydrostatic pressure;GO:0051602|response to electrical stimulus;GO:0051896|regulation of protein kinase B signaling;GO:0051965|positive regulation of synapse assembly;GO:0051968|positive regulation of synaptic transmission, glutamatergic;GO:0060009|Sertoli cell development;GO:0060384|innervation;GO:0060385|axonogenesis involved in innervation;GO:0061368|behavioral response to formalin induced pain;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071316|cellular response to nicotine;GO:0071363|cellular response to growth factor stimulus;GO:1901215|negative regulation of neuron death;GO:1990090|cellular response to nerve growth factor stimulus;","GO:0000139|Golgi membrane;GO:0005737|cytoplasm;GO:0005769|early endosome;GO:0005770|late endosome;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0030424|axon;GO:0030425|dendrite;GO:0031410|cytoplasmic vesicle;GO:0031901|early endosome membrane;GO:0031902|late endosome membrane;GO:0032991|protein-containing complex;GO:0043025|neuronal cell body;GO:0043235|receptor complex;GO:0055037|recycling endosome;GO:0055038|recycling endosome membrane;","GO:0004675|transmembrane receptor protein serine/threonine kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0005004|GPI-linked ephrin receptor activity;GO:0005030|neurotrophin receptor activity;GO:0005166|neurotrophin p75 receptor binding;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0010465|nerve growth factor receptor activity;GO:0019900|kinase binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0043121|neurotrophin binding;GO:0048406|nerve growth factor binding;","K03176","NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]"]
["ENSRNOG00000019963",14,0.900626135,3,0.193685579,4.649939037,2.217211802,5.666188E-3,0.003163278,"up","yes","Spats1","protein_coding","chr9:15527142-15562280:+","gi|31077120|ref|NP_852041.1|",1302,{"v":2E-176,"d":"2.00E-176"},"spermatogenesis-associated serine-rich protein 1 [Rattus norvegicus]","gi|31341076|ref|NM_181376.2|",838,0,"Rattus norvegicus spermatogenesis associated, serine-rich 1 (Spats1), mRNA",".",".",".",".",".",".",".",".","pfam15160","SASRP1","Spermatogenesis-associated serine-rich protein 1. Spermatogenesis-associated serine-rich protein 1 is a serine-rich protein differentially expressed during spermatogenesis.",".",".",".",".","."]
["ENSRNOG00000049759",14,0.900626135,3,0.193685579,4.649939037,2.217211802,5.666188E-3,0.003163278,"up","yes","Nlrp2","protein_coding","chr1:69515505-69554454:-","gi|109461167|ref|XP_001070923.1|",5236,0,"PREDICTED: NACHT, LRR and PYD domains-containing protein 2 isoform X1 [Rattus norvegicus]","gi|672013108|ref|XM_001070923.2|",3147,0,"PREDICTED: Rattus norvegicus similar to NACHT, leucine rich repeat and PYD containing 2 (LOC684545), transcript variant X1, mRNA","Q9NX02",813,0,"NACHT, LRR and PYD domains-containing protein 2",".",".",".",".","pfam05729","NACHT","NACHT domain. This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.","GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0032731|positive regulation of interleukin-1 beta production;GO:0043280|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;","GO:0000781|chromosome, telomeric region;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0043231|intracellular membrane-bounded organelle;","GO:0032090|Pyrin domain binding;","K19409","NLRP2; NACHT, LRR and PYD domains-containing protein 2"]
["ENSRNOG00000070513",14,0.900626135,3,0.193685579,4.649939037,2.217211802,5.666188E-3,0.003163278,"up","yes","ENSRNOG00000070513","protein_coding","chr17:41525999-41526621:-","gi|953881761|ref|XP_014590042.1|",406,{"v":5e-46,"d":"5.00E-46"},"PREDICTED: histone H4 [Equus caballus]","gi|672030048|ref|XM_008773972.1|",414,0,"PREDICTED: Rattus norvegicus histone H4-like (LOC102551184), mRNA","Q28DR4",150,{"v":8e-45,"d":"8.00E-45"},"Histone H4",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.",".",".",".",".","."]
["ENSRNOG00000055025",16,1.029287011,4,0.258247439,3.985662032,1.994819381,0.005685133,3.173024E-3,"up","yes","Fam25a","protein_coding","chr16:9680668-9684474:-","gi|148692929|gb|EDL24876.1|",229,{"v":6e-22,"d":"6.00E-22"},"RIKEN cDNA 2200001I15, partial [Mus musculus]","gi|198442839|ref|NM_001134849.1|",399,0,"Rattus norvegicus family with sequence similarity 25, member A (Fam25a), mRNA",".",".",".",".",".",".",".",".","pfam09900","DUF2127","Predicted membrane protein (DUF2127). This domain, found in various hypothetical prokaryotic and archaeal proteins, has no known function.",".",".",".",".","."]
["ENSRNOG00000026056",40,2.573217527,19,1.226675333,2.097716859,1.068819962,0.005949576,0.003313816,"up","yes","Ccnb1ip1","protein_coding","chr15:24014908-24028475:-","gi|564386005|ref|XP_006251963.1|",1583,0,"PREDICTED: E3 ubiquitin-protein ligase CCNB1IP1 isoform X3 [Rattus norvegicus]","gi|672077652|ref|XM_008770567.1|",1784,0,"PREDICTED: Rattus norvegicus cyclin B1 interacting protein 1, E3 ubiquitin protein ligase (Ccnb1ip1), transcript variant X5, mRNA","D3Z3K2",555,0,"E3 ubiquitin-protein ligase CCNB1IP1",".",".",".",".","pfam14634","zf-RING_5","zinc-RING finger domain.","GO:0001825|blastocyst formation;GO:0007131|reciprocal meiotic recombination;GO:0007286|spermatid development;GO:0016567|protein ubiquitination;GO:0051026|chiasma assembly;","GO:0000794|condensed nuclear chromosome;GO:0000795|synaptonemal complex;","GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;","K10639","CCNB1IP1, HEI10; E3 ubiquitin-protein ligase CCNP1IP1 [EC:2.3.2.27]"]
["ENSRNOG00000039379",31,1.994243584,13,0.839304176,2.37606775,1.248575973,0.006108409,3.397976E-3,"up","yes","C17h6orf52","protein_coding","chr17:23762746-23776245:+","gi|222537723|ref|NP_001138493.1|",829,{"v":1e-105,"d":"1.00E-105"},"putative uncharacterized protein C6orf52 homolog [Rattus norvegicus]","gi|222537722|ref|NM_001145021.1|",1581,0,"Rattus norvegicus similar to chromosome 6 open reading frame 52 (RGD1562963), mRNA",".",".",".",".",".",".",".",".","pfam05536","Neurochondrin","Neurochondrin. This family contains several eukaryotic neurochondrin proteins. Neurochondrin induces hydroxyapatite resorptive activity in bone marrow cells resistant to bafilomycin A1, an inhibitor of macrophage- and osteoclast-mediated resorption. Expression of the gene is localized to chondrocyte, osteoblast, and osteocyte in the bone and to the hippocampus and Purkinje cell layer of cerebellum in the brain.",".",".",".",".","."]
["ENSRNOG00000053317",31,1.994243584,13,0.839304176,2.37606775,1.248575973,0.006108409,3.397976E-3,"up","yes","Efcab11","protein_coding","chr6:119008919-119162046:-","gi|66730501|ref|NP_001019521.1|",857,{"v":3e-110,"d":"3.00E-110"},"EF-hand calcium-binding domain-containing protein 11 [Rattus norvegicus]","gi|66730500|ref|NM_001024350.1|",1463,0,"Rattus norvegicus EF-hand calcium binding domain 11 (Efcab11), mRNA","Q6AXQ2",334,{"v":9e-112,"d":"9.00E-112"},"EF-hand calcium-binding domain-containing protein 11","SPAC3A12.14",61.6,{"v":3E-10,"d":"3.00E-10"},"COG5126","pfam13499","EF-hand_7","EF-hand domain pair.",".",".","GO:0005509|calcium ion binding;","K23853","EFCAB11; EF-hand calcium-binding domain-containing protein 11"]
["ENSRNOG00000066215",31,1.994243584,13,0.839304176,2.37606775,1.248575973,0.006108409,3.397976E-3,"up","yes","ENSRNOG00000066215","protein_coding","chr13:74984404-74992395:-","gi|294831984|ref|NP_001171052.1|",186,{"v":4e-16,"d":"4.00E-16"},"uncharacterized protein LOC100038657 [Mus musculus]","gi|74193821|dbj|AK136134.1|",126,{"v":4e-58,"d":"4.00E-58"},"Mus musculus in vitro fertilized eggs cDNA, RIKEN full-length enriched library, clone:7420461P10 product:hypothetical protein, full insert sequence",".",".",".",".",".",".",".",".","pfam03443","Glyco_hydro_61","Glycosyl hydrolase family 61. Although weak endoglucanase activity has been demonstrated in several members of this family, they lack the clustered conserved catalytic acidic amino acids present in most glycoside hydrolases. Many members of this family lack measurable cellulase activity on their own, but enhance the activity of other cellulolytic enzymes. They are therefore unlikely to be true glycoside hydrolases.",".",".",".",".","."]
["ENSRNOG00000022286",23,1.479600078,8,0.516494877,2.864694585,1.518381337,0.006126747,3.407181E-3,"up","yes","AABR07039316.1","protein_coding","chrX:67928231-67963076:-","gi|672087893|ref|XP_008771551.1|",1292,{"v":8e-173,"d":"8.00E-173"},"PREDICTED: doublesex- and mab-3-related transcription factor C1-like isoform X3 [Rattus norvegicus]","gi|672032476|ref|XM_002727634.4|",1312,0,"PREDICTED: Rattus norvegicus DMRT-like family C1b (Dmrtc1b), transcript variant X2, mRNA","Q4QR87",99.8,{"v":3e-22,"d":"3.00E-22"},"Doublesex- and mab-3-related transcription factor C1",".",".",".",".","pfam06797","DUF1229","Protein of unknown function (DUF1229). This family consists of several hypothetical proteins of around 415 residues in length which seem to be specific to the bacterium Leptospira interrogans.",".",".",".","K19494","DMRT8, DMRTC1; doublesex- and mab-3-related transcription factor 8"]
["ENSRNOG00000015148",26,1.672591393,10,0.645618597,2.590680321,1.373331004,0.006873791,3.790879E-3,"up","yes","Erc2","protein_coding","chr16:2848620-3670776:+","gi|37360977|ref|NP_808482.2|",4265,0,"ERC protein 2 [Mus musculus]","gi|22138112|gb|AY049038.1|",2851,0,"Rattus norvegicus CAST1 mRNA, complete cds","Q8K3M6",1565,0,"ERC protein 2",".",".",".",".","pfam10174","Cast","RIM-binding protein of the cytomatrix active zone. This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.","GO:0007274|neuromuscular synaptic transmission;GO:0007416|synapse assembly;GO:0016082|synaptic vesicle priming;GO:0048167|regulation of synaptic plasticity;GO:0048790|maintenance of presynaptic active zone structure;GO:0050808|synapse organization;","GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005798|Golgi-associated vesicle;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0030426|growth cone;GO:0032991|protein-containing complex;GO:0042734|presynaptic membrane;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0045202|synapse;GO:0048786|presynaptic active zone;GO:0048788|cytoskeleton of presynaptic active zone;GO:0098831|presynaptic active zone cytoplasmic component;GO:0098978|glutamatergic synapse;GO:0098982|GABA-ergic synapse;","GO:0005515|protein binding;GO:0030165|PDZ domain binding;GO:0044877|protein-containing complex binding;GO:0098882|structural constituent of presynaptic active zone;","K19878","ERC2, CAST; ELKS/RAB6-interacting/CAST family member 2"]
["ENSRNOG00000068720",26,1.672591393,10,0.645618597,2.590680321,1.373331004,0.006873791,3.790879E-3,"up","yes","ENSRNOG00000068720","lncRNA","chr1:20232998-20265349:+","gi|149062621|gb|EDM13044.1|",131,5e-06,"rCG63645 [Rattus norvegicus]","gi|68532101|gb|AC153549.5|",542,0,"Mus musculus 10 BAC RP23-222O23 (Roswell Park Cancer Institute (C57BL/6J Female) Mouse BAC Library) complete sequence",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["ENSRNOG00000025480",41,2.637547966,20,1.291237193,2.042651791,1.03044329,0.006879047,3.793046E-3,"up","yes","AC135142.1","protein_coding","chr17:9832230-9835137:-","gi|672029758|ref|XP_008772153.1|",1017,{"v":6e-137,"d":"6.00E-137"},"PREDICTED: eukaryotic translation initiation factor 4E type 1B [Rattus norvegicus]","gi|672029757|ref|XM_008773931.1|",652,0,"PREDICTED: Rattus norvegicus eukaryotic translation initiation factor 4E family member 1B (Eif4e1b), mRNA","Q3UTA9",344,{"v":5e-118,"d":"5.00E-118"},"Eukaryotic translation initiation factor 4E type 1B","SPBC1709.18",111,{"v":3E-28,"d":"3.00E-28"},"COG5053","pfam01652","IF4E","Eukaryotic initiation factor 4E.",".",".",".","K03259","EIF4E; translation initiation factor 4E"]
["ENSRNOG00000004946",21,1.350939202,7,0.451933018,2.989246524,1.579781881,0.007015471,0.003863047,"up","yes","Cst12","protein_coding","chr3:136235041-136238909:+","gi|149041155|gb|EDL95088.1|",687,{"v":1E-89,"d":"1.00E-89"},"cystatin TE-1, isoform CRA_b [Rattus norvegicus]","gi|24308501|ref|NM_153734.1|",517,0,"Rattus norvegicus cystatin 12 (Cst12), mRNA","Q8VII2",261,{"v":5e-88,"d":"5.00E-88"},"Cystatin-12",".",".",".",".","pfam00031","Cystatin","Cystatin domain. Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 are related to this family but have not been included.","GO:0010951|negative regulation of endopeptidase activity;","GO:0005576|extracellular region;","GO:0004869|cysteine-type endopeptidase inhibitor activity;",".","."]
["ENSRNOG00000023299",21,1.350939202,7,0.451933018,2.989246524,1.579781881,0.007015471,0.003863047,"up","yes","Hfm1","protein_coding","chr14:2856599-2939238:+","gi|300797867|ref|NP_001178030.1|",7586,0,"probable ATP-dependent DNA helicase HFM1 [Rattus norvegicus]","gi|300797866|ref|NM_001191101.1|",4305,0,"Rattus norvegicus HFM1, ATP-dependent DNA helicase homolog (Hfm1), mRNA","D3Z4R1",2587,0,"Probable ATP-dependent DNA helicase HFM1","YGL251c",440,{"v":4e-130,"d":"4.00E-130"},"COG1204","pfam02889","Sec63","Sec63 Brl domain. This domain (also known as the Brl domain) is required for assembly of functional endoplasmic reticulum translocons.","GO:0000712|resolution of meiotic recombination intermediates;GO:0032508|DNA duplex unwinding;","GO:0005634|nucleus;","GO:0003676|nucleic acid binding;GO:0003678|DNA helicase activity;GO:0005524|ATP binding;","K15271","HFM1, MER3; ATP-dependent DNA helicase HFM1/MER3 [EC:5.6.2.4]"]
["ENSRNOG00000067261",21,1.350939202,7,0.451933018,2.989246524,1.579781881,0.007015471,0.003863047,"up","yes","ENSRNOG00000067261","lncRNA","chr7:90383054-90386387:+","gi|148675219|gb|EDL07166.1|",150,1E-8,"mCG1028420, partial [Mus musculus]","gi|307775457|gb|AC242295.4|",161,{"v":2e-76,"d":"2.00E-76"},"Rattus norvegicus Y Chr BAC RNAEX-220I17 (Amplicon Express Rat SHR-Akr BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam08449","UAA","UAA transporter family. This family includes transporters with a specificity for UDP-N-acetylglucosamine.",".",".",".",".","."]
["ENSRNOG00000019350",38,2.444556651,18,1.162113474,2.10354385,1.072821893,0.007165043,0.003935922,"up","yes","Lyzl4","protein_coding","chr8:121248168-121255353:-","gi|672063637|ref|XP_006244185.2|",876,{"v":6e-106,"d":"6.00E-106"},"PREDICTED: lysozyme-like protein 4 isoform X2 [Rattus norvegicus]","gi|672063638|ref|XM_006244125.2|",694,0,"PREDICTED: Rattus norvegicus lysozyme-like 4 (Lyzl4), transcript variant X2, mRNA","D4ABW7",275,{"v":2E-85,"d":"2.00E-85"},"Lysozyme-like protein 4",".",".",".",".","pfam00062","Lys","C-type lysozyme/alpha-lactalbumin family. Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.","GO:0007342|fusion of sperm to egg plasma membrane involved in single fertilization;GO:0009566|fertilization;","GO:0001669|acrosomal vesicle;GO:0005615|extracellular space;GO:0036126|sperm flagellum;",".","K25438","LYZL4; lysozyme-like protein 4"]
["ENSRNOG00000006251",9,0.578973944,1,0.06456186,8.967739572,3.164744382,7.217383E-3,0.003959722,"up","yes","Fam83a","protein_coding","chr7:89522826-89547388:+","gi|194474024|ref|NP_001124048.1|",2168,0,"protein FAM83A [Rattus norvegicus]","gi|672059232|ref|XM_008765518.1|",1577,0,"PREDICTED: Rattus norvegicus family with sequence similarity 83, member A (Fam83a), transcript variant X1, mRNA","Q8K2P2",800,0,"Protein FAM83A",".",".",".",".","pfam07894","DUF1669","Protein of unknown function (DUF1669). This family is composed of sequences derived from hypothetical eukaryotic proteins of unknown function. Some members of this family are annotated as being potential phospholipases but no literature was found to support this.","GO:0007165|signal transduction;GO:0007173|epidermal growth factor receptor signaling pathway;GO:0008283|cell proliferation;",".","GO:0019901|protein kinase binding;GO:0036312|phosphatidylinositol 3-kinase regulatory subunit binding;GO:0042802|identical protein binding;","K23930","FAM83; protein FAM83"]
["ENSRNOG00000017438",9,0.578973944,1,0.06456186,8.967739572,3.164744382,7.217383E-3,0.003959722,"up","yes","AABR07007068.1","protein_coding","chr1:257321742-257551473:-","gi|6978888|ref|NP_037091.1|",2291,0,"GDNF family receptor alpha-1 precursor [Rattus norvegicus]","gi|1399862|gb|U59486.1|RNU59486",2134,0,"Rattus norvegicus GDNF receptor alpha mRNA, complete cds","Q62997",882,0,"GDNF family receptor alpha-1",".",".",".",".","pfam02351","GDNF","GDNF/GAS1 domain. This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.",".",".",".",".","."]
["ENSRNOG00000047549",9,0.578973944,1,0.06456186,8.967739572,3.164744382,7.217383E-3,0.003959722,"up","yes","ENSRNOG00000047549","protein_coding","chr9:1704674-1727634:+","gi|564366863|ref|XP_006244385.1|",3701,0,"PREDICTED: uncharacterized protein LOC316124 isoform X1 [Rattus norvegicus]","gi|672063949|ref|XM_006244323.2|",2473,0,"PREDICTED: Rattus norvegicus similar to gonadotropin-regulated long chain acyl-CoA synthetase (LOC316124), transcript variant X1, mRNA","Q7ZYC4",599,0,"Long-chain-fatty-acid--CoA ligase ACSBG2","AF0200",169,{"v":3E-43,"d":"3.00E-43"},"COG1022","pfam00501","AMP-binding","AMP-binding enzyme.","GO:0008150|biological_process;GO:0042759|long-chain fatty acid biosynthetic process;","GO:0005575|cellular_component;GO:0005737|cytoplasm;","GO:0003674|molecular_function;GO:0004467|long-chain fatty acid-CoA ligase activity;GO:0016405|CoA-ligase activity;","K15013","ACSBG; long-chain-fatty-acid--CoA ligase ACSBG [EC:6.2.1.3]"]
["ENSRNOG00000051714",9,0.578973944,1,0.06456186,8.967739572,3.164744382,7.217383E-3,0.003959722,"up","yes","SNORA70","snoRNA","chr4:165144932-165145065:-","gi|859922493|ref|XP_012902851.1|",111,6e-06,"PREDICTED: 60S ribosomal protein L10-like [Mustela putorius furo]","gi|908663336|tpe|LN872540.1|",119,{"v":2e-54,"d":"2.00E-54"},"TPA: Mus musculus SNORA70 (U70) gene for small nucleolar RNA SNORA70 (U70)",".",".",".",".",".",".",".",".","pfam06267","DUF1028","Family of unknown function (DUF1028). Family of bacterial and archaeal proteins with unknown function. Some members are associated with a C-terminal peptidoglycan binding domain. So perhaps this could be an enzyme involved in peptidoglycan metabolizm.",".",".",".",".","."]
["ENSRNOG00000062961",9,0.578973944,1,0.06456186,8.967739572,3.164744382,7.217383E-3,0.003959722,"up","yes","ENSRNOG00000062961","lncRNA","chr1:35318705-35326361:-","gi|672064193|ref|XP_008765045.1|",304,{"v":1e-29,"d":"1.00E-29"},"PREDICTED: uncharacterized protein LOC685976 isoform X4 [Rattus norvegicus]","gi|672042620|ref|XR_591124.1|",476,0,"PREDICTED: Rattus norvegicus similar to nidogen 2 (LOC365085), transcript variant X16, misc_RNA","Q8R1R5",89.7,{"v":9e-19,"d":"9.00E-19"},"CD99 antigen-like protein 2",".",".",".",".","pfam06022","Cir_Bir_Yir","Plasmodium variant antigen protein Cir/Yir/Bir. This family consists of several Cir, Yir and Bir proteins from the Plasmodium species P.chabaudi, P.yoelii and P.berghei.",".",".",".",".","."]
["ENSRNOG00000063290",9,0.578973944,1,0.06456186,8.967739572,3.164744382,7.217383E-3,0.003959722,"up","yes","Hs3st4","protein_coding","chr1:178539093-178944107:+","gi|354983489|ref|NP_001239001.1|",1903,0,"heparan sulfate glucosamine 3-O-sulfotransferase 4 [Mus musculus]","gi|354983488|ref|NM_001252072.1|",1436,0,"Mus musculus heparan sulfate (glucosamine) 3-O-sulfotransferase 4 (Hs3st4), mRNA","Q9Y661",634,0,"Heparan sulfate glucosamine 3-O-sulfotransferase 4",".",".",".",".","pfam00685","Sulfotransfer_1","Sulfotransferase domain.",".",".",".",".","."]
["ENSRNOG00000066049",9,0.578973944,1,0.06456186,8.967739572,3.164744382,7.217383E-3,0.003959722,"up","yes","ENSRNOG00000066049","lncRNA","chr7:107854715-107856810:+","gi|149066135|gb|EDM16008.1|",154,{"v":5e-10,"d":"5.00E-10"},"rCG60114, isoform CRA_a [Rattus norvegicus]","gi|672059653|ref|XR_593605.1|",978,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102548374 (LOC102548374), transcript variant X7, ncRNA",".",".",".",".",".",".",".",".","pfam15005","IZUMO","Izumo sperm-egg fusion. Izumo is a molecule with a single immunoglobulin (Ig) domain. It is thought that Izumo bind to putative Izumo receptors on the oocyte. Izumo is not detectable on the surface of fresh sperm but becomes exposed only after an exocytotic process, the acrosome reaction, has occurred. Studies have shown that knock-out mice (Izumo-/- males) were sterile despite normal mating behaviour and ejaculation, indicating the importance of the protein in fertilization. There are cysteine residues thought to form a disulphide bridge. Izumo is a typical type I membrane glycoprotein with one immunoglobulin-like domain and a putative N-glycoside link motif (Asn 204). There is a conserved GCL sequence motif. Izumo expression has been found to be testis-specific. This family of proteins is found in eukaryotes and are typically between 193 and 305 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000067472",9,0.578973944,1,0.06456186,8.967739572,3.164744382,7.217383E-3,0.003959722,"up","yes","ENSRNOG00000067472","protein_coding","chr18:69179195-69180840:-","gi|157817320|ref|NP_001100845.1|",1148,{"v":1E-155,"d":"1.00E-155"},"peroxisomal biogenesis factor 19 isoform 1 [Rattus norvegicus]","gi|672030860|ref|XR_598361.1|",768,0,"PREDICTED: Rattus norvegicus peroxisomal biogenesis factor 19-like (LOC102548286), transcript variant X1, misc_RNA","Q9QYU1",445,{"v":1E-156,"d":"1.00E-156"},"Peroxisomal biogenesis factor 19",".",".",".",".","pfam04614","Pex19","Pex19 protein family.",".",".",".",".","."]
["ENSRNOG00000068596",9,0.578973944,1,0.06456186,8.967739572,3.164744382,7.217383E-3,0.003959722,"up","yes","ENSRNOG00000068596","lncRNA","chr17:10110742-10113602:-","gi|350537301|ref|NP_001233663.1|",163,{"v":8e-11,"d":"8.00E-11"},"uncharacterized protein LOC100689233 [Cricetulus griseus]","gi|672081208|ref|XR_596625.1|",489,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102551420 (LOC102551420), transcript variant X4, ncRNA",".",".",".",".",".",".",".",".","pfam02365","NAM","No apical meristem (NAM) protein. This is a family of no apical meristem (NAM) proteins these are plant development proteins. Mutations in NAM result in the failure to develop a shoot apical meristem in petunia embryos. NAM is indicated as having a role in determining positions of meristems and primordial. One member of this family NAP (NAC-like, activated by AP3/PI) is encoded by the target genes of the AP3/PI transcriptional activators and functions in the transition between growth by cell division and cell expansion in stamens and petals.",".",".",".",".","."]
["ENSRNOG00000071064",9,0.578973944,1,0.06456186,8.967739572,3.164744382,7.217383E-3,0.003959722,"up","yes","ENSRNOG00000071064","lncRNA","chr11:67518262-67522385:+",".",".",".",".","gi|320469099|gb|AC125727.5|",171,{"v":3e-82,"d":"3.00E-82"},"Rattus norvegicus BAC CH230-5G21 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam06189","5-nucleotidase","5'-nucleotidase. This family consists of both eukaryotic and prokaryotic 5'-nucleotidase sequences (EC:3.1.3.5).",".",".",".",".","."]
["ENSRNOG00000014256",35,2.251565336,16,1.032989754,2.179658924,1.124102398,0.00735825,0.004031585,"up","yes","Foxa3","protein_coding","chr1:78662431-78672155:-","gi|3461895|dbj|BAA32535.1|",1291,{"v":5e-173,"d":"5.00E-173"},"hepatocyte nuclear factor 3 gamma [Rattus norvegicus]","gi|3461894|dbj|AB017044.1|",1419,0,"Rattus norvegicus gene for hepatocyte nuclear factor 3 gamma, partial cds","P32183",501,{"v":7e-174,"d":"7.00E-174"},"Hepatocyte nuclear factor 3-gamma","ECU11g1330",94,{"v":1e-20,"d":"1.00E-20"},"COG5025","pfam00250","Fork_head","Fork head domain.","GO:0001678|cellular glucose homeostasis;GO:0006325|chromatin organization;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007283|spermatogenesis;GO:0008285|negative regulation of cell proliferation;GO:0009267|cellular response to starvation;GO:0009653|anatomical structure morphogenesis;GO:0030154|cell differentiation;GO:0031667|response to nutrient levels;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0061484|hematopoietic stem cell homeostasis;GO:0070368|positive regulation of hepatocyte differentiation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0015629|actin cytoskeleton;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0019904|protein domain specific binding;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K08038","FOXA3, HNF3G; forkhead box protein A3, hepatocyte nuclear factor 3-gamma"]
["ENSRNOG00000064929",32,2.058574022,14,0.903866035,2.277521161,1.187464459,0.007414416,0.004060411,"up","yes","ENSRNOG00000064929","processed_pseudogene","chr12:2069580-2070041:-","gi|157820113|ref|NP_001101794.1|",623,{"v":2E-79,"d":"2.00E-79"},"ran-specific GTPase-activating protein [Rattus norvegicus]","gi|157820112|ref|NM_001108324.1|",435,0,"Rattus norvegicus RAN binding protein 1 (Ranbp1), mRNA","P34022",242,{"v":3e-80,"d":"3.00E-80"},"Ran-specific GTPase-activating protein","SPBC1773.07c",130,{"v":1e-36,"d":"1.00E-36"},"COG5171","pfam00638","Ran_BP1","RanBP1 domain.",".",".",".",".","."]
["ENSRNOG00000023920",19,1.222278326,6,0.387371158,3.155315775,1.657784393,0.007930741,0.004328642,"up","yes","Zfp791","protein_coding","chr19:23018918-23033504:+","gi|672031152|ref|XP_008772431.1|",2948,0,"PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 791-like isoform X1 [Rattus norvegicus]","gi|672084603|ref|XM_008772433.1|",1746,0,"PREDICTED: Rattus norvegicus rCG51614-like (LOC100363196), transcript variant X3, mRNA","Q5REI6",758,0,"Zinc finger protein 791",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000063053",24,1.543930516,9,0.581056737,2.657108021,1.40985688,0.00807048,0.004401548,"up","yes","ENSRNOG00000063053","protein_coding","chr5:19001071-19001525:+","gi|157818349|ref|NP_001100012.1|",377,{"v":1e-43,"d":"1.00E-43"},"ubiquitin-conjugating enzyme E2 C [Rattus norvegicus]","gi|298911650|emb|FQ222472.1|",242,{"v":2e-122,"d":"2.00E-122"},"Rattus norvegicus TL0ADA23YA06 mRNA sequence","Q4R9D1",145,{"v":1e-43,"d":"1.00E-43"},"Ubiquitin-conjugating enzyme E2 C",".",".",".",".","pfam00179","UQ_con","Ubiquitin-conjugating enzyme. Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. TSG101 is one of several UBC homologues that lacks this active site cysteine.",".",".",".",".","."]
["ENSRNOG00000003062",39,2.508887089,19,1.226675333,2.045273937,1.032294086,0.00829577,0.004514933,"up","yes","AABR07039218.1","protein_coding","chrX:67672596-67673816:+","gi|77627906|ref|NP_001029305.1|",2161,0,"kelch domain-containing protein 2 [Rattus norvegicus]","gi|77627905|ref|NM_001034133.1|",1158,0,"Rattus norvegicus kelch domain containing 2 (Klhdc2), mRNA","Q3KRE6",837,0,"Kelch domain-containing protein 2",".",".",".",".","pfam13418","Kelch_4","Galactose oxidase, central domain.",".",".",".",".","."]
["ENSRNOG00000033515",17,1.093617449,5,0.322809298,3.387812727,1.760354127,0.008798512,0.004773084,"up","yes","ENSRNOG00000033515","protein_coding","chr13:82172573-82192948:+","gi|295391913|ref|NP_001171301.1|",1898,0,"uncharacterized protein LOC100366054 [Rattus norvegicus]","gi|295391912|ref|NM_001177830.1|",1195,0,"Rattus norvegicus Da1-10-like (LOC100366054), mRNA","Q62904",235,{"v":7E-72,"d":"7.00E-72"},"3-keto-steroid reductase",".",".",".",".","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.",".",".",".",".","."]
["ENSRNOG00000066982",17,1.093617449,5,0.322809298,3.387812727,1.760354127,0.008798512,0.004773084,"up","yes","ENSRNOG00000066982","protein_coding","chr9:113729880-113776907:+","gi|672018981|ref|XP_008774104.1|",2302,0,"PREDICTED: zinc finger protein 431-like isoform X1 [Rattus norvegicus]","gi|672018984|ref|XR_600914.1|",1686,0,"PREDICTED: Rattus norvegicus zinc finger protein 120-like (LOC102557117), misc_RNA","E9QAG8",669,0,"Zinc finger protein 431",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000069130",17,1.093617449,5,0.322809298,3.387812727,1.760354127,0.008798512,0.004773084,"up","yes","ENSRNOG00000069130","protein_coding","chr2:23585644-23607712:+","gi|45478192|gb|AAS66267.1|",1819,0,"LRRGT00176 [Rattus norvegicus]","gi|50838842|gb|AC099449.6|",2399,0,"Rattus norvegicus 1 BAC CH230-57B2 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P11260",496,{"v":3E-160,"d":"3.00E-160"},"LINE-1 retrotransposable element ORF1 protein","SPCC1223.08c_2",103,{"v":4e-23,"d":"4.00E-23"},"COG0262","pfam02994","Transposase_22","L1 transposable element.",".",".",".",".","."]
["ENSRNOG00000069551",17,1.093617449,5,0.322809298,3.387812727,1.760354127,0.008798512,0.004773084,"up","yes","ENSRNOG00000069551","lncRNA","chr19:56703631-56704783:-","gi|564396440|ref|XP_006255905.1|",157,6E-9,"PREDICTED: collagen alpha-1(I) chain-like [Rattus norvegicus]","gi|70721514|gb|AC156608.10|",331,{"v":3E-171,"d":"3.00E-171"},"Mus musculus chromosome 8, clone RP23-303A11, complete sequence",".",".",".",".",".",".",".",".","pfam02517","Abi","CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.",".",".",".",".","."]
["ENSRNOG00000039305",33,2.12290446,15,0.968427895,2.192114118,1.132322904,8.850452E-3,0.004800348,"up","yes","ENSRNOG00000039305","protein_coding","chrX:16368962-16372256:-","gi|672087112|ref|XP_006256826.2|",1348,{"v":2E-174,"d":"2.00E-174"},"PREDICTED: LOW QUALITY PROTEIN: retinitis pigmentosa 1-like 1 protein isoform X2 [Rattus norvegicus]","gi|672087111|ref|XM_006256764.2|",1700,0,"PREDICTED: Rattus norvegicus retinitis pigmentosa 1-like 1 protein-like (LOC102547118), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam07827","KNTase_C","KNTase C-terminal domain. Kanamycin nucleotidyltransferase (KNTase) is involved in conferring resistance to aminoglycoside antibiotics and catalyses the transfer of a nucleoside monophosphate group from a nucleotide to kanamycin. This enzyme is dimeric with each subunit being composed of two domains. The C-terminal domain contains five alpha helices, four of which are organized into an up-and-down alpha helical bundle. Residues found in this domain may contribute to this enzyme's active site.","GO:0048599|oocyte development;GO:0061086|negative regulation of histone H3-K27 methylation;GO:1902465|negative regulation of histone H3-K27 trimethylation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0044877|protein-containing complex binding;",".","."]
["ENSRNOG00000058291",30,1.929913146,13,0.839304176,2.299420403,1.201270258,0.008884071,0.004816672,"up","yes","AC126581.1","protein_coding","chr1:202110352-202110961:+","gi|589931307|ref|XP_006978458.1|",447,{"v":6e-54,"d":"6.00E-54"},"PREDICTED: 60S ribosomal protein L29 [Peromyscus maniculatus bairdii]","gi|51233511|gb|AC118628.11|",196,{"v":1e-96,"d":"1.00E-96"},"Mus musculus chromosome 19, clone RP24-92P15, complete sequence","P47915",159,{"v":2e-48,"d":"2.00E-48"},"60S ribosomal protein L29",".",".",".",".","pfam01779","Ribosomal_L29e","Ribosomal L29e protein family.",".",".",".",".","."]
["ENSRNOG00000002158",11,0.70763482,2,0.129123719,5.480285294,2.454250999,0.009182956,0.004961845,"up","yes","Ibsp","protein_coding","chr14:5439829-5452693:-","gi|149046722|gb|EDL99496.1|",1122,{"v":9e-145,"d":"9.00E-145"},"integrin binding sialoprotein, isoform CRA_a [Rattus norvegicus]","gi|158303313|ref|NM_012587.2|",1930,0,"Rattus norvegicus integrin-binding sialoprotein (Ibsp), mRNA","P13839",370,{"v":6e-121,"d":"6.00E-121"},"Bone sialoprotein 2",".",".",".",".","pfam05432","BSP_II","Bone sialoprotein II (BSP-II). Bone sialoprotein (BSP) is a major structural protein of the bone matrix that is specifically expressed by fully-differentiated osteoblasts. The expression of bone sialoprotein (BSP) is normally restricted to mineralised connective tissues of bones and teeth where it has been associated with mineral crystal formation. However, it has been found that ectopic expression of BSP occurs in various lesions, including oral and extraoral carcinomas, in which it has been associated with the formation of microcrystalline deposits and the metastasis of cancer cells to bone.","GO:0001503|ossification;GO:0007155|cell adhesion;GO:0007229|integrin-mediated signaling pathway;GO:0030198|extracellular matrix organization;GO:0030282|bone mineralization;GO:0045785|positive regulation of cell adhesion;GO:0071363|cellular response to growth factor stimulus;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0031012|extracellular matrix;GO:0031982|vesicle;","GO:0005178|integrin binding;","K06253","IBSP; integrin binding sialoprotein"]
["ENSRNOG00000007509",11,0.70763482,2,0.129123719,5.480285294,2.454250999,0.009182956,0.004961845,"up","yes","Slc1a6","protein_coding","chr7:10841837-10870449:-","gi|672058057|ref|XP_008763404.1|",2653,0,"PREDICTED: excitatory amino acid transporter 4 isoform X1 [Rattus norvegicus]","gi|672058056|ref|XM_008765182.1|",2014,0,"PREDICTED: Rattus norvegicus solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 (Slc1a6), transcript variant X1, mRNA","O35921",1020,0,"Excitatory amino acid transporter 4","aq_1330",161,{"v":2e-42,"d":"2.00E-42"},"COG1301","pfam00375","SDF","Sodium:dicarboxylate symporter family.","GO:0001504|neurotransmitter uptake;GO:0015813|L-glutamate transmembrane transport;GO:0042391|regulation of membrane potential;GO:0098712|L-glutamate import across plasma membrane;","GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0045111|intermediate filament cytoskeleton;GO:0098688|parallel fiber to Purkinje cell synapse;GO:0098796|membrane protein complex;GO:0098978|glutamatergic synapse;GO:0099055|integral component of postsynaptic membrane;GO:0099056|integral component of presynaptic membrane;","GO:0005313|L-glutamate transmembrane transporter activity;GO:0005314|high-affinity glutamate transmembrane transporter activity;GO:0008509|anion transmembrane transporter activity;GO:0015293|symporter activity;GO:0046872|metal ion binding;","K05617","SLC1A6, EAAT4; solute carrier family 1 (high affinity glutamate/aspartate transporter), member 6"]
["ENSRNOG00000017775",11,0.70763482,2,0.129123719,5.480285294,2.454250999,0.009182956,0.004961845,"up","yes","Slc5a1","protein_coding","chr14:77553843-77618547:-","gi|6981552|ref|NP_037165.1|",2947,0,"sodium/glucose cotransporter 1 [Rattus norvegicus]","gi|414571|gb|U03120.1|RNU03120",2624,0,"Rattus norvegicus Sprague-Dawley sodium-glucose cotransporter 1 mRNA, complete cds","P53790",1139,0,"Sodium/glucose cotransporter 1","yidK",121,{"v":9e-28,"d":"9.00E-28"},"COG4146","pfam00474","SSF","Sodium:solute symporter family. Membership of this family is supported by a significant blast score.","GO:0000017|alpha-glucoside transport;GO:0001656|metanephros development;GO:0001951|intestinal D-glucose absorption;GO:0006814|sodium ion transport;GO:0010035|response to inorganic substance;GO:0032409|regulation of transporter activity;GO:0035377|transepithelial water transport;GO:0050892|intestinal absorption;GO:0098708|glucose import across plasma membrane;GO:0098719|sodium ion import across plasma membrane;GO:1904659|glucose transmembrane transport;","GO:0005769|early endosome;GO:0005886|plasma membrane;GO:0005903|brush border;GO:0005911|cell-cell junction;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0031526|brush border membrane;GO:0043229|intracellular organelle;GO:0048471|perinuclear region of cytoplasm;","GO:0005355|glucose transmembrane transporter activity;GO:0005372|water transmembrane transporter activity;GO:0005412|glucose:sodium symporter activity;GO:0015151|alpha-glucoside transmembrane transporter activity;GO:0055056|D-glucose transmembrane transporter activity;","K14158","SLC5A1, SGLT1; solute carrier family 5 (sodium/glucose cotransporter), member 1"]
["ENSRNOG00000019661",11,0.70763482,2,0.129123719,5.480285294,2.454250999,0.009182956,0.004961845,"up","yes","Gdf15","protein_coding","chr16:18805239-18808055:+","gi|149036052|gb|EDL90718.1|",1249,{"v":5e-169,"d":"5.00E-169"},"growth differentiation factor 15 [Rattus norvegicus]","gi|257153310|ref|NM_019216.2|",906,0,"Rattus norvegicus growth differentiation factor 15 (Gdf15), mRNA","Q9Z0J6",481,{"v":1E-168,"d":"1.00E-168"},"Growth/differentiation factor 15",".",".",".",".","pfam00019","TGF_beta","Transforming growth factor beta like domain.","GO:0002023|reduction of food intake in response to dietary excess;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0030509|BMP signaling pathway;GO:0035860|glial cell-derived neurotrophic factor receptor signaling pathway;GO:0040015|negative regulation of multicellular organism growth;GO:0043410|positive regulation of MAPK cascade;GO:0051897|positive regulation of protein kinase B signaling;GO:0060395|SMAD protein signal transduction;GO:0060400|negative regulation of growth hormone receptor signaling pathway;GO:1901741|positive regulation of myoblast fusion;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;","GO:0005125|cytokine activity;GO:0008083|growth factor activity;GO:0042803|protein homodimerization activity;GO:0070700|BMP receptor binding;","K05504","GDF15; growth differentiation factor 15"]
["ENSRNOG00000026247",11,0.70763482,2,0.129123719,5.480285294,2.454250999,0.009182956,0.004961845,"up","yes","AABR07018326.1","protein_coding","chr15:44921886-45134191:+","gi|149049873|gb|EDM02197.1|",1107,{"v":6e-149,"d":"6.00E-149"},"rCG37031, isoform CRA_b [Rattus norvegicus]","gi|554790270|ref|NM_028560.4|",576,0,"Mus musculus phosphatidylethanolamine binding protein 4 (Pebp4), transcript variant 1, mRNA","Q9D9G2",318,{"v":3e-106,"d":"3.00E-106"},"Phosphatidylethanolamine-binding protein 4",".",".",".",".","pfam01161","PBP","Phosphatidylethanolamine-binding protein.",".",".",".",".","."]
["ENSRNOG00000030243",11,0.70763482,2,0.129123719,5.480285294,2.454250999,0.009182956,0.004961845,"up","yes","Lrp1b","protein_coding","chr3:24594991-26715505:-","gi|153792247|ref|NP_443737.2|",22681,0,"low-density lipoprotein receptor-related protein 1B precursor [Mus musculus]","gi|153792246|ref|NM_053011.2|",12360,0,"Mus musculus low density lipoprotein-related protein 1B (deleted in tumors) (Lrp1b), mRNA","Q9JI18",8739,0,"Low-density lipoprotein receptor-related protein 1B",".",".",".",".","pfam00057","Ldl_recept_a","Low-density lipoprotein receptor domain class A.",".",".",".",".","."]
["ENSRNOG00000046852",11,0.70763482,2,0.129123719,5.480285294,2.454250999,0.009182956,0.004961845,"up","yes","B3gat2","protein_coding","chr9:26167174-26250153:+","gi|12018284|ref|NP_072131.1|",1727,0,"galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 precursor [Rattus norvegicus]","gi|451958053|ref|NM_022609.2|",1993,0,"Rattus norvegicus beta-1,3-glucuronyltransferase 2 (B3gat2), mRNA","Q9Z137",669,0,"Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2",".",".",".",".","pfam03360","Glyco_transf_43","Glycosyltransferase family 43.","GO:0005975|carbohydrate metabolic process;GO:0006486|protein glycosylation;GO:0016051|carbohydrate biosynthetic process;GO:0050650|chondroitin sulfate proteoglycan biosynthetic process;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0015018|galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity;GO:0046872|metal ion binding;","K10157","B3GAT2; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 [EC:2.4.1.135]"]
["ENSRNOG00000054444",11,0.70763482,2,0.129123719,5.480285294,2.454250999,0.009182956,0.004961845,"up","yes","RNaseP_nuc","ribozyme","chr20:46304592-46305062:-",".",".",".",".","gi|49615144|gb|AC094571.8|",471,0,"Rattus norvegicus 20 BAC CH230-4L21 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam15351","JCAD","Junctional protein associated with coronary artery disease. JCAD is a component of VE-cadherin-based cell-cell junctions in endothelial cells. The cell-cell or adherens junction is an adhesion complex that plays a crucial role in the organisation and function of epithelial and endothelial cellular sheets. These junctions join the actin cytoskeleton to the plasma membrane to form adhesive contacts between cells or between cells and extracellular matrix. The junctions also mediate both cell adhesion and cell-signalling. JCAD localizes close to the apical membrane in epithelial cells. This family is found in eukaryotes.",".",".",".",".","."]
["ENSRNOG00000066257",11,0.70763482,2,0.129123719,5.480285294,2.454250999,0.009182956,0.004961845,"up","yes","ENSRNOG00000066257","lncRNA","chr1:87300676-87436420:-","gi|149066522|gb|EDM16395.1|",146,2E-8,"rCG59786 [Rattus norvegicus]","gi|28604194|gb|AC123805.4|",642,0,"Mus musculus BAC clone RP24-150A12 from chromosome 7, complete sequence",".",".",".",".",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.",".",".",".",".","."]
["ENSRNOG00000066701",11,0.70763482,2,0.129123719,5.480285294,2.454250999,0.009182956,0.004961845,"up","yes","ENSRNOG00000066701","protein_coding","chr1:168472329-168472610:-","gi|385178598|sp|D3Z9R8.1|68MP_RAT",268,{"v":1e-28,"d":"1.00E-28"},"RecName: Full=6.8 kDa mitochondrial proteolipid","gi|672021183|ref|XR_347572.2|",279,{"v":6e-143,"d":"6.00E-143"},"PREDICTED: Rattus norvegicus 6.8 kDa mitochondrial proteolipid-like (LOC100912557), ncRNA","D3Z9R8",107,{"v":3e-30,"d":"3.00E-30"},"6.8 kDa mitochondrial proteolipid",".",".",".",".","pfam08039","Mit_proteolip","Mitochondrial proteolipid. This family consists of proteins with similarity to the mitochondrial proteolipids. Mitochondrial proteolipid consists of about 60 amino acids residues and is about 6.8 kDa in size.",".",".",".",".","."]
["ENSRNOG00000051294",22,1.41526964,8,0.516494877,2.740142647,1.454250999,0.009427694,0.005085425,"up","yes","AABR07034923.1","protein_coding","chr12:46534-56425:-","gi|293340970|ref|XP_002724811.1|",1394,0,"PREDICTED: ZAR1-like protein isoform X1 [Rattus norvegicus]","gi|293340969|ref|XM_002724765.1|",879,0,"PREDICTED: Rattus norvegicus zygote arrest 1-like (Zar1l), transcript variant X1, mRNA","A6NP61",300,{"v":8e-99,"d":"8.00E-99"},"ZAR1-like protein",".",".",".",".","pfam13695","zf-3CxxC","Zinc-binding domain. This is a family with several pairs of CxxC motifs possibly representing a multiple zinc-binding region. Only one pair of cysteines is associated with a highly conserved histidine residue.",".",".",".",".","."]
["ENSRNOG00000054529",13,0.836295696,3,0.193685579,4.317800535,2.110296598,0.009744625,0.005244494,"up","yes","Gm25395","scaRNA","chr9:88442065-88442334:+",".",".",".",".","gi|354789701|gb|JN954202.1|",223,{"v":8e-112,"d":"8.00E-112"},"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Atg16l1:tm1a(EUCOMM)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam06517","Orthopox_A43R","Orthopoxvirus A43R protein. This family consists of several Orthopoxvirus A43R proteins. The function of this family is unknown.",".",".",".",".","."]
["ENSRNOG00000062927",13,0.836295696,3,0.193685579,4.317800535,2.110296598,0.009744625,0.005244494,"up","yes","ENSRNOG00000062927","protein_coding","chr2:183779559-183809469:+","gi|27372732|gb|AAO06264.1|",792,{"v":1e-94,"d":"1.00E-94"},"histone protein Hist2h3c1 [Mus musculus]","gi|516302|emb|X80330.1|",1798,0,"C.longicaudatus genes for histones H2a.2 and H3.2","P84239",274,{"v":3e-84,"d":"3.00E-84"},"Histone H3",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.",".",".",".",".","."]
["ENSRNOG00000069782",13,0.836295696,3,0.193685579,4.317800535,2.110296598,0.009744625,0.005244494,"up","yes","ENSRNOG00000069782","protein_coding","chr14:83991841-83992591:+","gi|752383373|ref|XP_011231108.1|",990,{"v":5e-131,"d":"5.00E-131"},"PREDICTED: transmembrane protein 161B isoform X3 [Ailuropoda melanoleuca]","gi|672028140|ref|XM_008766650.1|",546,0,"PREDICTED: Rattus norvegicus similar to CG7638-PA (LOC685655), mRNA","Q8C2L6",327,{"v":3e-108,"d":"3.00E-108"},"Transmembrane protein 161B",".",".",".",".","pfam10268","Tmemb_161AB","Predicted transmembrane protein 161AB. Transmemb_161AB is a family of conserved proteins found from worms to humans. Members are putative transmembrane proteins but otherwise the function is not known.",".",".",".",".","."]
["ENSRNOG00000064521",37,2.380226213,18,1.162113474,2.048187433,1.034347745,0.010012145,0.005379347,"up","yes","Hist2h3c2","protein_coding","chr17:41560880-41561441:-","gi|170053486|ref|XP_001862696.1|",712,{"v":7e-93,"d":"7.00E-93"},"Histone H3c [Culex quinquefasciatus]","gi|672081879|ref|XM_006253990.2|",562,0,"PREDICTED: Rattus norvegicus similar to CG31613-PA (LOC684841), mRNA","P84239",275,{"v":3e-93,"d":"3.00E-93"},"Histone H3",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.",".",".",".",".","."]
["ENSRNOG00000047473",25,1.608260955,10,0.645618597,2.49103877,1.316747476,0.010280546,5.517844E-3,"up","yes","Dchs2","protein_coding","chr2:168478826-168682732:+","gi|564300462|ref|XP_006224215.1|",16915,0,"PREDICTED: protocadherin-23-like [Rattus norvegicus]","gi|672042786|ref|XM_006232535.2|",10044,0,"PREDICTED: Rattus norvegicus dachsous cadherin-related 2 (Dchs2), mRNA","Q6V1P9",3657,0,"Protocadherin-23",".",".",".",".","pfam00028","Cadherin","Cadherin domain.",".",".",".",".","."]
["ENSRNOG00000064760",34,2.187234898,16,1.032989754,2.117382954,1.082282222,0.010412036,5.58422E-3,"up","yes","ENSRNOG00000064760","lncRNA","chr9:109308360-109321450:-","gi|149036268|gb|EDL90927.1|",285,{"v":1E-27,"d":"1.00E-27"},"rCG35633 [Rattus norvegicus]","gi|672024416|ref|XR_589357.1|",1558,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102552880 (LOC102552880), ncRNA",".",".",".",".",".",".",".",".","pfam11819","DUF3338","Domain of unknown function (DUF3338). This family of proteins are functionally uncharacterized. This family is found in eukaryotes. This presumed domain is about 130 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000029871",31,1.994243584,14,0.903866035,2.206348625,1.141660769,0.010649376,0.005685882,"up","yes","Slc8a3","protein_coding","chr6:100874369-101007508:-","gi|149025046|gb|EDL81413.1|",4785,0,"rCG20829, isoform CRA_b [Rattus norvegicus]","gi|767172179|ref|NM_078620.2|",4296,0,"Rattus norvegicus solute carrier family 8 member A3 (Slc8a3), mRNA","S4R2P9",1820,0,"Sodium/calcium exchanger 3",".",".",".",".","pfam03160","Calx-beta","Calx-beta domain.","GO:0002244|hematopoietic progenitor cell differentiation;GO:0006814|sodium ion transport;GO:0006851|mitochondrial calcium ion transmembrane transport;GO:0006874|cellular calcium ion homeostasis;GO:0007154|cell communication;GO:0007611|learning or memory;GO:0007612|learning;GO:0007613|memory;GO:0014819|regulation of skeletal muscle contraction;GO:0021537|telencephalon development;GO:0030001|metal ion transport;GO:0035725|sodium ion transmembrane transport;GO:0042552|myelination;GO:0048709|oligodendrocyte differentiation;GO:0050808|synapse organization;GO:0051560|mitochondrial calcium ion homeostasis;GO:0060291|long-term synaptic potentiation;GO:0060402|calcium ion transport into cytosol;GO:0070588|calcium ion transmembrane transport;GO:0071320|cellular response to cAMP;GO:0071456|cellular response to hypoxia;GO:0071901|negative regulation of protein serine/threonine kinase activity;GO:0098703|calcium ion import across plasma membrane;GO:0098815|modulation of excitatory postsynaptic potential;GO:0099566|regulation of postsynaptic cytosolic calcium ion concentration;GO:1990034|calcium ion export across plasma membrane;","GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0005789|endoplasmic reticulum membrane;GO:0005874|microtubule;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0016528|sarcoplasm;GO:0030424|axon;GO:0030425|dendrite;GO:0031226|intrinsic component of plasma membrane;GO:0031594|neuromuscular junction;GO:0042383|sarcolemma;GO:0042995|cell projection;GO:0043025|neuronal cell body;GO:0043197|dendritic spine;GO:0043204|perikaryon;GO:0043679|axon terminus;GO:0045202|synapse;GO:0048471|perinuclear region of cytoplasm;GO:0098794|postsynapse;GO:0099055|integral component of postsynaptic membrane;","GO:0005432|calcium:sodium antiporter activity;GO:0005516|calmodulin binding;GO:0015368|calcium:cation antiporter activity;GO:0015491|cation:cation antiporter activity;GO:0046872|metal ion binding;GO:0099580|ion antiporter activity involved in regulation of postsynaptic membrane potential;GO:1905060|calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration;","K05849","SLC8A, NCX; solute carrier family 8 (sodium/calcium exchanger)"]
["ENSRNOG00000040242",31,1.994243584,14,0.903866035,2.206348625,1.141660769,0.010649376,0.005685882,"up","yes","Epm2a","protein_coding","chr1:5727066-5920555:+","gi|454522491|ref|NP_001263691.1|",1591,0,"laforin [Rattus norvegicus]","gi|14335441|gb|AF347030.1|AF347030",2394,0,"Rattus norvegicus dual-specificity phosphatase laforin (Epm2a) mRNA, partial cds","Q91XQ2",617,0,"Laforin",".",".",".",".","pfam00782","DSPc","Dual specificity phosphatase, catalytic domain. Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a \"recognition\" region.","GO:0000045|autophagosome assembly;GO:0001558|regulation of cell growth;GO:0001932|regulation of protein phosphorylation;GO:0005977|glycogen metabolic process;GO:0005978|glycogen biosynthetic process;GO:0006470|protein dephosphorylation;GO:0006816|calcium ion transport;GO:0006914|autophagy;GO:0007005|mitochondrion organization;GO:0007399|nervous system development;GO:0010468|regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010923|negative regulation of phosphatase activity;GO:0014009|glial cell proliferation;GO:0015813|L-glutamate transmembrane transport;GO:0016055|Wnt signaling pathway;GO:0016239|positive regulation of macroautophagy;GO:0016311|dephosphorylation;GO:0031396|regulation of protein ubiquitination;GO:0032007|negative regulation of TOR signaling;GO:0033137|negative regulation of peptidyl-serine phosphorylation;GO:0035305|negative regulation of dephosphorylation;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0042306|regulation of protein import into nucleus;GO:0042325|regulation of phosphorylation;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0044260|cellular macromolecule metabolic process;GO:0045786|negative regulation of cell cycle;GO:0045859|regulation of protein kinase activity;GO:0046835|carbohydrate phosphorylation;GO:0046838|phosphorylated carbohydrate dephosphorylation;GO:0046959|habituation;GO:0061136|regulation of proteasomal protein catabolic process;GO:1903076|regulation of protein localization to plasma membrane;GO:1904666|regulation of ubiquitin protein ligase activity;GO:2000465|regulation of glycogen (starch) synthase activity;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005844|polysome;GO:0005886|plasma membrane;GO:0030425|dendrite;GO:0043204|perikaryon;GO:0098554|cytoplasmic side of endoplasmic reticulum membrane;GO:0098556|cytoplasmic side of rough endoplasmic reticulum membrane;","GO:0004373|glycogen (starch) synthase activity;GO:0004721|phosphoprotein phosphatase activity;GO:0004722|protein serine/threonine phosphatase activity;GO:0004725|protein tyrosine phosphatase activity;GO:0008138|protein tyrosine/serine/threonine phosphatase activity;GO:0016791|phosphatase activity;GO:0019203|carbohydrate phosphatase activity;GO:0030246|carbohydrate binding;GO:0030247|polysaccharide binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0046983|protein dimerization activity;GO:2001069|glycogen binding;GO:2001070|starch binding;","K14165","K14165; atypical dual specificity phosphatase [EC:3.1.3.16 3.1.3.48]"]
["ENSRNOG00000000508",7,0.450313067,0,0.03228093,13.94981711,3.802174303,0.010805042,0.005753933,"up","yes","Armc12","protein_coding","chr20:6587859-6598352:+","gi|166157536|ref|NP_001107249.1|",1790,0,"armadillo repeat-containing protein 12 [Rattus norvegicus]","gi|166157535|ref|NM_001113777.1|",1213,0,"Rattus norvegicus armadillo repeat containing 12 (Armc12), mRNA",".",".",".",".",".",".",".",".","pfam04826","Arm_2","Armadillo-like. This domain contains armadillo-like repeats. Proteins containing this domain interact with numerous other proteins, through these interactions they are involved in a wide variety of processes including carcinogenesis, control of cellular ageing and survival, regulation of circadian rhythm and lysosomal sorting of G protein-coupled receptors.",".",".",".","K24168","ARMC12; armadillo repeat-containing protein 12"]
["ENSRNOG00000002911",7,0.450313067,0,0.03228093,13.94981711,3.802174303,0.010805042,0.005753933,"up","yes","Alb","protein_coding","chr14:17607381-17622836:-","gi|158138568|ref|NP_599153.2|",3178,0,"serum albumin precursor [Rattus norvegicus]","gi|158138567|ref|NM_134326.2|",1801,0,"Rattus norvegicus albumin (Alb), mRNA","P02770",1227,0,"Serum albumin",".",".",".",".","pfam00273","Serum_albumin","Serum albumin family.","GO:0001895|retina homeostasis;GO:0006810|transport;GO:0007584|response to nutrient;GO:0009267|cellular response to starvation;GO:0010033|response to organic substance;GO:0042311|vasodilation;GO:0043066|negative regulation of apoptotic process;GO:0046010|positive regulation of circadian sleep/wake cycle, non-REM sleep;GO:0046689|response to mercury ion;GO:0051659|maintenance of mitochondrion location;GO:0070541|response to platinum ion;","GO:0005576|extracellular region;GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0032991|protein-containing complex;GO:0070062|extracellular exosome;","GO:0003677|DNA binding;GO:0005504|fatty acid binding;GO:0008270|zinc ion binding;GO:0015643|toxic substance binding;GO:0019825|oxygen binding;GO:0019899|enzyme binding;GO:0030170|pyridoxal phosphate binding;GO:0036094|small molecule binding;GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0051087|chaperone binding;GO:0072341|modified amino acid binding;GO:1903981|enterobactin binding;","K16141","ALB; serum albumin"]
["ENSRNOG00000011225",7,0.450313067,0,0.03228093,13.94981711,3.802174303,0.010805042,0.005753933,"up","yes","ENSRNOG00000011225","protein_coding","chr18:37761420-37763069:+","gi|672030654|ref|XP_008772346.1|",1407,0,"PREDICTED: LOW QUALITY PROTEIN: ELMO domain-containing protein 2-like isoform X1 [Rattus norvegicus]","gi|672083588|ref|XM_008772180.1|",603,0,"PREDICTED: Rattus norvegicus ELMO domain-containing protein 2-like (LOC102554034), transcript variant X2, mRNA","Q8BGF6",524,0,"ELMO domain-containing protein 2",".",".",".",".","pfam04727","ELMO_CED12","ELMO/CED-12 family. This family represents a conserved domain which is found in a number of eukaryotic proteins including CED-12, ELMO I and ELMO II. ELMO1 is a component of signalling pathways that regulate phagocytosis and cell migration and is the mammalian orthologue of the C. elegans gene, ced-12. CED-12 is required for the engulfment of dying cells and cell migration. In mammalian cells, ELMO1 interacts with Dock180 as part of the CrkII/Dock180/Rac pathway responsible for phagocytosis and cell migration. ELMO1 is ubiquitously expressed, although its expression is highest in the spleen, an organ rich in immune cells. ELMO1 has a PH domain and a polyproline sequence motif at its C terminus which are not present in this alignment.",".",".",".",".","."]
["ENSRNOG00000026848",7,0.450313067,0,0.03228093,13.94981711,3.802174303,0.010805042,0.005753933,"up","yes","Tex36","protein_coding","chr1:188390064-188404377:-","gi|66730345|ref|NP_001019459.1|",1159,{"v":2e-158,"d":"2.00E-158"},"testis-expressed sequence 36 protein [Rattus norvegicus]","gi|66730344|ref|NM_001024288.1|",814,0,"Rattus norvegicus testis expressed 36 (Tex36), mRNA",".",".",".",".",".",".",".",".","pfam15115","HDNR","Domain of unknown function with conserved HDNR motif. This family of proteins is found in eukaryotes. Proteins in this family are typically between 117 and 219 amino acids in length. There is a conserved HDNR sequence motif. The function is not known.",".",".",".",".","."]
["ENSRNOG00000027478",7,0.450313067,0,0.03228093,13.94981711,3.802174303,0.010805042,0.005753933,"up","yes","Krtap11-1","protein_coding","chr11:28810341-28810892:-","gi|392332254|ref|XP_003752520.1|",896,{"v":1e-120,"d":"1.00E-120"},"PREDICTED: keratin-associated protein 11-1 [Rattus norvegicus]","gi|672025861|ref|XM_003752472.3|",552,0,"PREDICTED: Rattus norvegicus keratin associated protein 11-1 (Krtap11-1), mRNA","Q8IUC1",241,{"v":9e-80,"d":"9.00E-80"},"Keratin-associated protein 11-1",".",".",".",".","pfam05287","PMG","PMG protein. This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteristic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.",".",".",".",".","."]
["ENSRNOG00000038095",7,0.450313067,0,0.03228093,13.94981711,3.802174303,0.010805042,0.005753933,"up","yes","Ccdc169","protein_coding","chr2:139321670-139351161:+","gi|157821783|ref|NP_001102654.1|",1011,{"v":4e-129,"d":"4.00E-129"},"coiled-coil domain-containing protein 169 [Rattus norvegicus]","gi|157821782|ref|NM_001109184.1|",2271,0,"Rattus norvegicus coiled-coil domain containing 169 (Ccdc169), mRNA",".",".",".",".",".",".",".",".","pfam15372","DUF4600","Domain of unknown function (DUF4600).",".",".",".",".","."]
["ENSRNOG00000042692",7,0.450313067,0,0.03228093,13.94981711,3.802174303,0.010805042,0.005753933,"up","yes","AABR07027750.1","protein_coding","chr17:41222049-41253304:-","gi|51036671|ref|NP_598238.2|",2377,0,"sodium-dependent phosphate transport protein 1 [Rattus norvegicus]","gi|51036670|ref|NM_133554.2|",1823,0,"Rattus norvegicus solute carrier family 17 member 1 (Slc17a1), mRNA","Q62795",913,0,"Sodium-dependent phosphate transport protein 1",".",".",".",".","pfam07690","MFS_1","Major Facilitator Superfamily.",".",".",".",".","."]
["ENSRNOG00000060338",7,0.450313067,0,0.03228093,13.94981711,3.802174303,0.010805042,0.005753933,"up","yes","Lipc","protein_coding","chr8:71509635-71635464:-","gi|564364442|ref|XP_006243421.1|",2754,0,"PREDICTED: hepatic triacylglycerol lipase isoform X2 [Rattus norvegicus]","gi|672061820|ref|XM_006243359.2|",1722,0,"PREDICTED: Rattus norvegicus lipase, hepatic (Lipc), transcript variant X1, mRNA","P07867",1004,0,"Hepatic triacylglycerol lipase",".",".",".",".","pfam00151","Lipase","Lipase.","GO:0001666|response to hypoxia;GO:0001889|liver development;GO:0006629|lipid metabolic process;GO:0006631|fatty acid metabolic process;GO:0006633|fatty acid biosynthetic process;GO:0006641|triglyceride metabolic process;GO:0006658|phosphatidylserine metabolic process;GO:0007623|circadian rhythm;GO:0008203|cholesterol metabolic process;GO:0009410|response to xenobiotic stimulus;GO:0009725|response to hormone;GO:0009743|response to carbohydrate;GO:0010034|response to acetate;GO:0010035|response to inorganic substance;GO:0014070|response to organic cyclic compound;GO:0015012|heparan sulfate proteoglycan biosynthetic process;GO:0016042|lipid catabolic process;GO:0019433|triglyceride catabolic process;GO:0030301|cholesterol transport;GO:0031667|response to nutrient levels;GO:0032026|response to magnesium ion;GO:0032870|cellular response to hormone stimulus;GO:0033993|response to lipid;GO:0034371|chylomicron remodeling;GO:0034372|very-low-density lipoprotein particle remodeling;GO:0034374|low-density lipoprotein particle remodeling;GO:0034375|high-density lipoprotein particle remodeling;GO:0034382|chylomicron remnant clearance;GO:0034383|low-density lipoprotein particle clearance;GO:0042632|cholesterol homeostasis;GO:0043200|response to amino acid;GO:0043434|response to peptide hormone;GO:0046337|phosphatidylethanolamine metabolic process;GO:0046461|neutral lipid catabolic process;GO:0046470|phosphatidylcholine metabolic process;GO:0046473|phosphatidic acid metabolic process;GO:0046475|glycerophospholipid catabolic process;GO:0046688|response to copper ion;GO:0048589|developmental growth;GO:0051384|response to glucocorticoid;GO:0051592|response to calcium ion;GO:0070328|triglyceride homeostasis;GO:0070542|response to fatty acid;GO:0097006|regulation of plasma lipoprotein particle levels;","GO:0005615|extracellular space;GO:0005769|early endosome;GO:0005770|late endosome;GO:0005902|microvillus;GO:0009986|cell surface;GO:0034364|high-density lipoprotein particle;","GO:0004465|lipoprotein lipase activity;GO:0004620|phospholipase activity;GO:0004622|lysophospholipase activity;GO:0004806|triglyceride lipase activity;GO:0008201|heparin binding;GO:0008289|lipid binding;GO:0008970|phospholipase A1 activity;GO:0016298|lipase activity;GO:0016746|transferase activity, transferring acyl groups;GO:0030169|low-density lipoprotein particle binding;GO:0034185|apolipoprotein binding;GO:0035478|chylomicron binding;GO:0042802|identical protein binding;GO:0043395|heparan sulfate proteoglycan binding;GO:0046872|metal ion binding;GO:0047372|acylglycerol lipase activity;GO:0052689|carboxylic ester hydrolase activity;GO:0052739|phosphatidylserine 1-acylhydrolase activity;GO:0052740|1-acyl-2-lysophosphatidylserine acylhydrolase activity;GO:0102545|phosphatidyl phospholipase B activity;","K22283","LIPC; hepatic triacylglycerol lipase [EC:3.1.1.3]"]
["ENSRNOG00000063167",7,0.450313067,0,0.03228093,13.94981711,3.802174303,0.010805042,0.005753933,"up","yes","Hist1h3b","protein_coding","chr17:42723450-42723911:+","gi|564320036|ref|XP_002725328.3|",746,{"v":4e-96,"d":"4.00E-96"},"PREDICTED: uncharacterized protein LOC680498 [Rattus norvegicus]","gi|672082321|ref|XM_001057443.4|",462,0,"PREDICTED: Rattus norvegicus similar to CG31613-PA (LOC680498), mRNA","Q6LED0",275,{"v":3e-94,"d":"3.00E-94"},"Histone H3.1",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.",".",".",".",".","."]
["ENSRNOG00000063726",7,0.450313067,0,0.03228093,13.94981711,3.802174303,0.010805042,0.005753933,"up","yes","Zfp42l","protein_coding","chr4:157334760-157345452:+","gi|564349006|ref|XP_006237450.1|",1577,0,"PREDICTED: zinc finger protein 42-like isoform X2 [Rattus norvegicus]","gi|672051090|ref|XM_006237388.2|",1763,0,"PREDICTED: Rattus norvegicus Zinc finger protein 42-like (Zfp42l), transcript variant X2, mRNA","P22227",448,{"v":1e-140,"d":"1.00E-140"},"Zinc finger protein 42",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.",".",".",".",".","."]
["ENSRNOG00000065032",7,0.450313067,0,0.03228093,13.94981711,3.802174303,0.010805042,0.005753933,"up","yes","ENSRNOG00000065032","lncRNA","chr9:105812119-105817907:+","gi|45478186|gb|AAS66264.1|",240,{"v":3e-19,"d":"3.00E-19"},"LRRGT00173 [Rattus norvegicus]","gi|82465629|gb|AC158530.2|",151,{"v":3e-71,"d":"3.00E-71"},"Mus musculus BAC clone RP23-255H12 from chromosome 17, complete sequence","P11369",90.1,{"v":2e-18,"d":"2.00E-18"},"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam00078","RVT_1","Reverse transcriptase (RNA-dependent DNA polymerase). A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs, hepadnaviruses, and caulimoviruses.",".",".",".",".","."]
["ENSRNOG00000065438",7,0.450313067,0,0.03228093,13.94981711,3.802174303,0.010805042,0.005753933,"up","yes","Fam163b","protein_coding","chr3:10437383-10466458:-","gi|157822553|ref|NP_001102928.1|",766,{"v":3e-97,"d":"3.00E-97"},"protein FAM163B [Rattus norvegicus]","gi|157822552|ref|NM_001109458.1|",1313,0,"Rattus norvegicus family with sequence similarity 163, member B (Fam163b), mRNA","Q8BUM6",298,{"v":4e-98,"d":"4.00E-98"},"Protein FAM163B",".",".",".",".","pfam15069","FAM163","FAM163 family. This protein family is alternatively named Neuroblastoma-derived secretory proteins. Highly expressed in neuroblastoma compared to other tissues, suggesting that it may be used as a marker for metastasis in bone marrow.",".",".",".",".","."]
["ENSRNOG00000066027",7,0.450313067,0,0.03228093,13.94981711,3.802174303,0.010805042,0.005753933,"up","yes","Necab1","protein_coding","chr5:28357859-28578642:-","gi|568927338|ref|XP_006538297.1|",1471,0,"PREDICTED: N-terminal EF-hand calcium-binding protein 1 isoform X1 [Mus musculus]","gi|11560136|ref|NM_022302.1|",1170,0,"Rattus norvegicus N-terminal EF-hand calcium binding protein 1 (Necab1), mRNA","Q9ESB5",566,0,"N-terminal EF-hand calcium-binding protein 1",".",".",".",".","pfam03992","ABM","Antibiotic biosynthesis monooxygenase. This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.",".",".",".",".","."]
["ENSRNOG00000066153",7,0.450313067,0,0.03228093,13.94981711,3.802174303,0.010805042,0.005753933,"up","yes","ENSRNOG00000066153","protein_coding","chr10:81068011-81069397:-","gi|149053970|gb|EDM05787.1|",436,{"v":1E-52,"d":"1.00E-52"},"similar to nuclear domain 10 protein (predicted), partial [Rattus norvegicus]","gi|672069430|ref|XM_008768252.1|",239,{"v":1e-120,"d":"1.00E-120"},"PREDICTED: Rattus norvegicus calcium binding and coiled-coil domain 2 (Calcoco2), transcript variant X2, mRNA","A2A6M5",137,{"v":1e-38,"d":"1.00E-38"},"Calcium-binding and coiled-coil domain-containing protein 2",".",".",".",".","pfam07888","CALCOCO1","Calcium binding and coiled-coil domain (CALCOCO1) like. Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.",".",".",".",".","."]
["ENSRNOG00000066640",7,0.450313067,0,0.03228093,13.94981711,3.802174303,0.010805042,0.005753933,"up","yes","ENSRNOG00000066640","lncRNA","chr9:58947007-58949768:-",".",".",".",".","gi|672024020|ref|XR_349052.2|",982,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102549484 (LOC102549484), transcript variant X2, ncRNA",".",".",".",".",".",".",".",".","pfam14121","DUF4289","Domain of unknown function (DUF4289). This family of membrane bet-barrel proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 655 and 722 amino acids in length. One member is identified by Gene3D as a membrane bound beta-barrel.",".",".",".",".","."]
["ENSRNOG00000067781",7,0.450313067,0,0.03228093,13.94981711,3.802174303,0.010805042,0.005753933,"up","yes","U6","snRNA","chr20:30667294-30667400:+","gi|537152882|gb|ERE72362.1|",174,{"v":2E-14,"d":"2.00E-14"},"membralin-like protein [Cricetulus griseus]","gi|354781831|gb|JN946332.1|",104,{"v":3e-46,"d":"3.00E-46"},"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Creld2:tm1e(EUCOMM)Hmgu tm1e(EUCOMM)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam08538","DUF1749","Protein of unknown function (DUF1749). This is a plant and fungal family of unknown function. This family contains many hypothetical proteins.",".",".",".",".","."]
["ENSRNOG00000043103",23,1.479600078,9,0.581056737,2.546395187,1.348456335,0.012178825,6.445241E-3,"up","yes","Frrs1l","protein_coding","chr5:71659284-71690108:-","gi|442580969|sp|D3ZE85.1|FRS1L_RAT",1380,{"v":3e-179,"d":"3.00E-179"},"RecName: Full=DOMON domain-containing protein FRRS1L; AltName: Full=Ferric-chelate reductase 1-like protein; Flags: Precursor","gi|672052704|ref|XM_345535.8|",3257,0,"PREDICTED: Rattus norvegicus ferric-chelate reductase 1-like (Frrs1l), transcript variant X2, mRNA","D3ZE85",536,{"v":1E-180,"d":"1.00E-180"},"DOMON domain-containing protein FRRS1L",".",".",".",".","pfam03351","DOMON","DOMON domain. The DOMON (named after dopamine beta-monooxygenase N-terminal) domain is 110-125 residues long. It is predicted to form an all beta fold with up to 11 strands and is secreted to the extracellular compartment. The beta-strand folding produces a hydrophobic pocket which appears to bind soluble haem. This is consistent with the predominant architectures where the protein is associated with cytochromes or enzymatic domains whose activity involves redox or electron transfer reactions potentially as a direct participant in the electron transfer process. The DOMON domain superfamily, of which this is just one member, shows (1) multiple hydrophobic residues that contribute to the hydrophobic core of the strands of the beta-sandwich, and small residues found at the boundaries of strands and loops, (2) a strongly conserved charged residue (usually arginine/lysine) at the end of strand 9, which possibly stabilizes the loop between 9 and 10, and (3) a polar residue (usually histidine, lysine or arginine), that interacts or coordinates with ligands. The suggested superfamily includes both haem- and sugar-binding members: the haem-binding families being the ethyl-Benzoate dehydrogenase family EB_dh, pfam09459, the cellobiose dehydrogenase family CBDH and this family, and the sugar-binding families being the xylanases, CBM_4_9, pfam02018. The common feature of the superfamily is the 11-beta-strand structure, although the first and eleventh strands are not well conserved either within families or between families.","GO:0099072|regulation of postsynaptic membrane neurotransmitter receptor levels;GO:1900449|regulation of glutamate receptor signaling pathway;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0045202|synapse;",".","K25381","FRRS1L; DOMON domain-contaning protein FRRS1L"]
["ENSRNOG00000064376",23,1.479600078,9,0.581056737,2.546395187,1.348456335,0.012178825,6.445241E-3,"up","yes","RGD1562660","protein_coding","chr19:22509598-22514258:+","gi|564323679|ref|XP_006227195.1|",1140,{"v":9e-155,"d":"9.00E-155"},"PREDICTED: uncharacterized protein LOC367516 [Rattus norvegicus]","gi|672033535|ref|XM_006227133.2|",853,0,"PREDICTED: Rattus norvegicus hypothetical LOC367516 (LOC367516), mRNA",".",".",".",".",".",".",".",".","pfam04822","Takusan","Takusan. This domain is named takusan, which is a Japanese word meaning 'many'. Members of this family regulate synaptic activity.",".",".",".",".","."]
["ENSRNOG00000065573",23,1.479600078,9,0.581056737,2.546395187,1.348456335,0.012178825,6.445241E-3,"up","yes","ENSRNOG00000065573","lncRNA","chr4:119016421-119030519:+","gi|149036634|gb|EDL91252.1|",298,{"v":1e-29,"d":"1.00E-29"},"rCG56486 [Rattus norvegicus]","gi|672018511|ref|XR_345941.2|",1214,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102554372 (LOC102554372), ncRNA",".",".",".",".",".",".",".",".","pfam14971","DUF4510","Domain of unknown function (DUF4510). This family of proteins is found in eukaryotes. Proteins in this family are typically between 242 and 452 amino acids in length. There are two conserved sequence motifs: LEA and WMD.",".",".",".",".","."]
["ENSRNOG00000069840",23,1.479600078,9,0.581056737,2.546395187,1.348456335,0.012178825,6.445241E-3,"up","yes","Pcdh11x","protein_coding","chrX:86058394-86747036:+","gi|403420604|ref|NP_001258157.1|",6915,0,"protocadherin-11 X-linked precursor [Rattus norvegicus]","gi|672088065|ref|XM_008773375.1|",4385,0,"PREDICTED: Rattus norvegicus protocadherin 11 X-linked (Pcdh11x), transcript variant X1, mRNA","Q6X862",2235,0,"Protocadherin-11 X-linked",".",".",".",".","pfam08374","Protocadherin","Protocadherin. The structure of protocadherins is similar to that of classic cadherins (pfam00028), but particularly on the cytoplasmic domains they also have some unique features. They are expressed in a variety of organisms and are found in high concentrations in the brain where they seem to be localized mainly at cell-cell contact sites. Their expression seems to be developmentally regulated.",".",".",".",".","."]
["ENSRNOG00000060281",32,2.058574022,15,0.968427895,2.125686417,1.087928785,0.012564877,0.006637246,"up","yes","AABR07031691.1","protein_coding","chr18:26022706-26023633:-","gi|45478146|gb|AAS66244.1|",181,{"v":8e-16,"d":"8.00E-16"},"LRRGT00153 [Rattus norvegicus]","gi|672030573|ref|XM_008774109.1|",231,{"v":2E-116,"d":"2.00E-116"},"PREDICTED: Rattus norvegicus protein SET-like (LOC103694185), mRNA",".",".",".",".",".",".",".",".","pfam00956","NAP","Nucleosome assembly protein (NAP). NAP proteins are involved in moving histones into the nucleus, nucleosome assembly and chromatin fluidity. They affect the transcription of many genes.",".",".",".",".","."]
["ENSRNOG00000068893",32,2.058574022,15,0.968427895,2.125686417,1.087928785,0.012564877,0.006637246,"up","yes","ENSRNOG00000068893","protein_coding","chr9:106007571-106018505:-","gi|148706381|gb|EDL38328.1|",1115,{"v":4e-147,"d":"4.00E-147"},"DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae), isoform CRA_b, partial [Mus musculus]","gi|672033321|ref|XM_008758172.1|",513,0,"PREDICTED: Rattus norvegicus DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 (Ddx11), transcript variant X2, mRNA","Q6AXC6",429,{"v":8e-141,"d":"8.00E-141"},"ATP-dependent DNA helicase DDX11","SPAC3G6.11",103,{"v":4e-23,"d":"4.00E-23"},"COG1199","pfam06733","DEAD_2","DEAD_2. This represents a conserved region within a number of RAD3-like DNA-binding helicases that are seemingly ubiquitous - members include proteins of eukaryotic, bacterial and archaeal origin. RAD3 is involved in nucleotide excision repair, and forms part of the transcription factor TFIIH in yeast.",".",".",".",".","."]
["ENSRNOG00000062084",29,1.865582707,13,0.839304176,2.222773056,1.152360658,0.012818569,0.006760002,"up","yes","ENSRNOG00000062084","protein_coding","chr13:3545171-3547153:-","gi|74188945|dbj|BAE39243.1|",2102,0,"unnamed protein product [Mus musculus]","gi|672073561|ref|XR_595423.1|",829,0,"PREDICTED: Rattus norvegicus similar to heat shock protein 1, alpha (LOC680491), transcript variant X2, misc_RNA","P07901",813,0,"Heat shock protein HSP 90-alpha","SPAC926.04c",506,{"v":3E-171,"d":"3.00E-171"},"COG0326","pfam00183","HSP90","Hsp90 protein.",".",".",".",".","."]
["ENSRNOG00000009050",8,0.514643505,1,0.06456186,7.971324064,2.994819381,0.013563572,0.007108907,"up","yes","Amn","protein_coding","chr6:130311372-130318815:+","gi|157823609|ref|NP_001101531.1|",2103,0,"protein amnionless precursor [Rattus norvegicus]","gi|157823608|ref|NM_001108061.1|",1759,0,"Rattus norvegicus amnion associated transmembrane protein (Amn), mRNA","Q99JB7",740,0,"Protein amnionless",".",".",".",".","pfam14828","Amnionless","Amnionless. The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.","GO:0006898|receptor-mediated endocytosis;GO:0007588|excretion;GO:0008104|protein localization;GO:0008150|biological_process;GO:0015889|cobalamin transport;GO:0043001|Golgi to plasma membrane protein transport;","GO:0005615|extracellular space;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0030139|endocytic vesicle;GO:0031526|brush border membrane;GO:0032991|protein-containing complex;GO:0045177|apical part of cell;","GO:0003674|molecular_function;GO:0005102|signaling receptor binding;","K18259","AMN; protein amnionless"]
["ENSRNOG00000010162",8,0.514643505,1,0.06456186,7.971324064,2.994819381,0.013563572,0.007108907,"up","yes","Tex38","protein_coding","chr5:129261552-129264673:-","gi|564352464|ref|XP_006238780.1|",1044,{"v":1e-140,"d":"1.00E-140"},"PREDICTED: testis-expressed sequence 38 protein isoform X1 [Rattus norvegicus]","gi|672053569|ref|XM_006238718.2|",888,0,"PREDICTED: Rattus norvegicus testis expressed 38 (Tex38), transcript variant X1, mRNA","A2A8T7",345,{"v":4e-118,"d":"4.00E-118"},"Testis-expressed protein 38",".",".",".",".","pfam04780","DUF629","Protein of unknown function (DUF629). This family represents a region of several plant proteins of unknown function. A C2H2 zinc finger is predicted in this region in some family members, but the spacing between the cysteine residues is not conserved throughout the family.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000012340",8,0.514643505,1,0.06456186,7.971324064,2.994819381,0.013563572,0.007108907,"up","yes","Tmco2","protein_coding","chr5:134664692-134669291:-","gi|293359506|ref|XP_002729571.1|",977,{"v":3e-130,"d":"3.00E-130"},"PREDICTED: transmembrane and coiled-coil domain-containing protein 2 [Rattus norvegicus]","gi|672053986|ref|XM_002729525.4|",1021,0,"PREDICTED: Rattus norvegicus transmembrane and coiled-coil domains 2 (Tmco2), mRNA","P0C1V4",349,{"v":3e-119,"d":"3.00E-119"},"Transmembrane and coiled-coil domain-containing protein 2",".",".",".",".","pfam15489","CTC1","CST, telomere maintenance, complex subunit CTC1. CTC1 is one of the three components of the CST complex that assists Shelterin to protect the ends of telomeres from attack by DNA-repair mechanisms. Mutations in human CTC1 have been recognized as contributing to cerebroretinal microangiopathy.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000013768",8,0.514643505,1,0.06456186,7.971324064,2.994819381,0.013563572,0.007108907,"up","yes","Defb1","protein_coding","chr16:70298863-70313604:-","gi|13929150|ref|NP_113998.1|",360,{"v":8e-42,"d":"8.00E-42"},"beta-defensin 1 precursor [Rattus norvegicus]","gi|13929149|ref|NM_031810.1|",392,0,"Rattus norvegicus defensin beta 1 (Defb1), mRNA","O89117",143,{"v":3E-43,"d":"3.00E-43"},"Beta-defensin 1",".",".",".",".","pfam00711","Defensin_beta","Beta defensin. The beta defensins are antimicrobial peptides implicated in the resistance of epithelial surfaces to microbial colonisation.","GO:0002227|innate immune response in mucosa;GO:0002526|acute inflammatory response;GO:0009617|response to bacterium;GO:0019731|antibacterial humoral response;GO:0019933|cAMP-mediated signaling;GO:0031640|killing of cells of other organism;GO:0033574|response to testosterone;GO:0035584|calcium-mediated signaling using intracellular calcium source;GO:0042742|defense response to bacterium;GO:0045087|innate immune response;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:0060474|positive regulation of flagellated sperm motility involved in capacitation;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;","GO:0005615|extracellular space;GO:0019898|extrinsic component of membrane;GO:0097225|sperm midpiece;GO:1990742|microvesicle;","GO:0003674|molecular_function;GO:0003690|double-stranded DNA binding;GO:0031731|CCR6 chemokine receptor binding;GO:0042802|identical protein binding;","K23125","DEFB1; beta-defensin 1"]
["ENSRNOG00000019607",8,0.514643505,1,0.06456186,7.971324064,2.994819381,0.013563572,0.007108907,"up","yes","Bglap","protein_coding","chr2:173838518-173839495:-","gi|11761543|ref|NP_038200.1|",465,{"v":8e-57,"d":"8.00E-57"},"osteocalcin preproprotein [Rattus norvegicus]","gi|672042873|ref|XM_006232594.2|",487,0,"PREDICTED: Rattus norvegicus bone gamma-carboxyglutamate (gla) protein (Bglap), transcript variant X1, mRNA","P04640",183,{"v":3e-58,"d":"3.00E-58"},"Osteocalcin",".",".",".",".","pfam00594","Gla","Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain. This domain is responsible for the high-affinity binding of calcium ions. This domain contains post-translational modifications of many glutamate residues by Vitamin K-dependent carboxylation to form gamma-carboxyglutamate (Gla).","GO:0001503|ossification;GO:0001649|osteoblast differentiation;GO:0002076|osteoblast development;GO:0007568|aging;GO:0007569|cell aging;GO:0009410|response to xenobiotic stimulus;GO:0009612|response to mechanical stimulus;GO:0009629|response to gravity;GO:0010035|response to inorganic substance;GO:0010043|response to zinc ion;GO:0014070|response to organic cyclic compound;GO:0014823|response to activity;GO:0030500|regulation of bone mineralization;GO:0031214|biomineral tissue development;GO:0031667|response to nutrient levels;GO:0032571|response to vitamin K;GO:0033280|response to vitamin D;GO:0033574|response to testosterone;GO:0033594|response to hydroxyisoflavone;GO:0042476|odontogenesis;GO:0043627|response to estrogen;GO:0045471|response to ethanol;GO:0051384|response to glucocorticoid;GO:0060348|bone development;GO:0071305|cellular response to vitamin D;GO:0071363|cellular response to growth factor stimulus;GO:0071773|cellular response to BMP stimulus;GO:1900076|regulation of cellular response to insulin stimulus;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005791|rough endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0030425|dendrite;GO:0031982|vesicle;GO:0042995|cell projection;GO:0043204|perikaryon;GO:0062023|collagen-containing extracellular matrix;","GO:0005509|calcium ion binding;GO:0008147|structural constituent of bone;GO:0046848|hydroxyapatite binding;GO:0046914|transition metal ion binding;GO:0048306|calcium-dependent protein binding;","K22609","BGLAP; osteocalcin"]
["ENSRNOG00000037687",8,0.514643505,1,0.06456186,7.971324064,2.994819381,0.013563572,0.007108907,"up","yes","Rspo2","protein_coding","chr7:74103090-74238933:-","gi|194474018|ref|NP_001124047.1|",1195,{"v":5e-153,"d":"5.00E-153"},"R-spondin-2 precursor [Rattus norvegicus]","gi|194474017|ref|NM_001130575.1|",3223,0,"Rattus norvegicus R-spondin 2 (Rspo2), mRNA","Q8BFU0",425,{"v":6e-139,"d":"6.00E-139"},"R-spondin-2",".",".",".",".","pfam03302","VSP","Giardia variant-specific surface protein.","GO:0001649|osteoblast differentiation;GO:0008150|biological_process;GO:0016055|Wnt signaling pathway;GO:0030177|positive regulation of Wnt signaling pathway;GO:0030282|bone mineralization;GO:0035115|embryonic forelimb morphogenesis;GO:0035116|embryonic hindlimb morphogenesis;GO:0042489|negative regulation of odontogenesis of dentin-containing tooth;GO:0060173|limb development;GO:0060437|lung growth;GO:0060441|epithelial tube branching involved in lung morphogenesis;GO:0060535|trachea cartilage morphogenesis;GO:0071542|dopaminergic neuron differentiation;GO:0090263|positive regulation of canonical Wnt signaling pathway;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0009986|cell surface;","GO:0003674|molecular_function;GO:0005102|signaling receptor binding;GO:0008201|heparin binding;","K23097","RSPO2; R-spondin 2"]
["ENSRNOG00000038165",8,0.514643505,1,0.06456186,7.971324064,2.994819381,0.013563572,0.007108907,"up","yes","Pjvk","protein_coding","chr3:61596641-61605045:+","gi|564301884|ref|XP_006224560.1|",1804,0,"PREDICTED: pejvakin isoform X1 [Rattus norvegicus]","gi|672016995|ref|XM_006224498.2|",1104,0,"PREDICTED: Rattus norvegicus deafness, autosomal recessive 59 (Dfnb59), transcript variant X1, mRNA","Q0ZLH2",693,0,"Pejvakin",".",".",".",".","pfam04598","Gasdermin","Gasdermin family. The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein","GO:0000302|response to reactive oxygen species;GO:0000425|pexophagy;GO:0007605|sensory perception of sound;GO:0008219|cell death;GO:0050910|detection of mechanical stimulus involved in sensory perception of sound;GO:0097468|programmed cell death in response to reactive oxygen species;GO:0120045|stereocilium maintenance;GO:1900063|regulation of peroxisome organization;","GO:0005737|cytoplasm;GO:0005778|peroxisomal membrane;GO:0030864|cortical actin cytoskeleton;GO:0035253|ciliary rootlet;GO:0043025|neuronal cell body;GO:0120044|stereocilium base;",".","K22147","PJVK, DFNB59; pejvakin"]
["ENSRNOG00000042727",8,0.514643505,1,0.06456186,7.971324064,2.994819381,0.013563572,0.007108907,"up","yes","RGD1563159","protein_coding","chr18:29480474-29481239:-","gi|157822805|ref|NP_001101898.1|",642,{"v":1e-82,"d":"1.00E-82"},"uncharacterized protein LOC361312 [Rattus norvegicus]","gi|157822804|ref|NM_001108428.1|",634,0,"Rattus norvegicus RGD1563159 (RGD1563159), mRNA",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSRNOG00000053082",8,0.514643505,1,0.06456186,7.971324064,2.994819381,0.013563572,0.007108907,"up","yes","AABR07029741.1","snoRNA","chr10:47272113-47272242:+",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","pfam15471","TMEM171","Transmembrane protein family 171. This family of proteins is found in eukaryotes. TMEM171 is also known as parturition-related protein 2. Proteins in this family are typically between 242 and 326 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000063033",8,0.514643505,1,0.06456186,7.971324064,2.994819381,0.013563572,0.007108907,"up","yes","ENSRNOG00000063033","lncRNA","chr15:98883429-98884679:+",".",".",".",".","gi|74218175|gb|AC165155.2|",582,0,"Mus musculus BAC clone RP23-293N22 from chromosome 14, complete sequence",".",".",".",".",".",".",".",".","pfam06952","PsiA","PsiA protein. This family consists of several Enterobacterial PsiA proteins. The function of PsiA is unknown although it is thought that it may affect the generation of an SOS signal in Escherichia coli.",".",".",".",".","."]
["ENSRNOG00000065937",8,0.514643505,1,0.06456186,7.971324064,2.994819381,0.013563572,0.007108907,"up","yes","ENSRNOG00000065937","protein_coding","chr3:45456139-45457335:-","gi|74204612|dbj|BAE35376.1|",918,{"v":9e-121,"d":"9.00E-121"},"unnamed protein product [Mus musculus]","gi|298915721|emb|FQ213223.1|",494,0,"Rattus norvegicus TL0AAA49YA18 mRNA sequence","Q9CX56",357,{"v":6e-121,"d":"6.00E-121"},"26S proteasome non-ATPase regulatory subunit 8",".",".",".",".","pfam03399","SAC3_GANP","SAC3/GANP/Nin1/mts3/eIF-3 p25 family. This large family includes diverse proteins involved in large complexes. The alignment contains one highly conserved negatively charged residue and one highly conserved positively charged residue that are probably important for the function of these proteins. The family includes the yeast nuclear export factor Sac3, and mammalian GANP/MCM3-associated proteins, which facilitate the nuclear localisation of MCM3, a protein that associates with chromatin in the G1 phase of the cell-cycle. The 26S protease (or 26S proteasome) is responsible for degrading ubiquitin conjugates. It consists of 19S regulatory complexes associated with the ends of 20S proteasomes. The 19S regulatory complex is composed of about 20 different polypeptides and confers ATP-dependence and substrate specificity to the 26S enzyme. The conserved region occurs at the C-terminal of the Nin1-like regulatory subunit. This family includes several eukaryotic translation initiation factor 3 subunit 11 (eIF-3 p25) proteins. Eukaryotic initiation factor 3 (eIF3) is a multisubunit complex that is required for binding of mRNA to 40 S ribosomal subunits, stabilisation of ternary complex binding to 40 S subunits, and dissociation of 40 and 60 S subunits.",".",".",".",".","."]
["ENSRNOG00000066676",8,0.514643505,1,0.06456186,7.971324064,2.994819381,0.013563572,0.007108907,"up","yes","ENSRNOG00000066676","lncRNA","chr4:11773595-11783462:+","gi|149036607|gb|EDL91225.1|",133,{"v":4e-11,"d":"4.00E-11"},"rCG56442 [Rattus norvegicus]","gi|644988607|tpe|HG979546.1|",123,{"v":1e-55,"d":"1.00E-55"},"TPA: Mus musculus long non-coding RNA OTTMUST00000120169.1 (RP23-443N7.2 gene), lincRNA",".",".",".",".",".",".",".",".","pfam12449","DUF3684","Protein of unknown function (DUF3684). This domain family is found in eukaryotes, and is typically between 1072 and 1090 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000066961",8,0.514643505,1,0.06456186,7.971324064,2.994819381,0.013563572,0.007108907,"up","yes","ENSRNOG00000066961","lncRNA","chr1:16088167-16092477:-",".",".",".",".","gi|66792979|gb|AC153557.8|",515,0,"Mus musculus 10 BAC RP23-203H20 (Roswell Park Cancer Institute (C57BL/6J Female) Mouse BAC Library) complete sequence",".",".",".",".",".",".",".",".","pfam05287","PMG","PMG protein. This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteristic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.",".",".",".",".","."]
["ENSRNOG00000003370",16,1.029287011,5,0.322809298,3.188529626,1.672891286,0.014199627,0.007412345,"up","yes","Otc","protein_coding","chrX:12453834-12566918:-","gi|56789151|gb|AAH88158.1|",1840,0,"Otc protein [Rattus norvegicus]","gi|6981311|ref|NM_013078.1|",1106,0,"Rattus norvegicus ornithine carbamoyltransferase (Otc), mRNA","P00481",696,0,"Ornithine carbamoyltransferase, mitochondrial","SPAC4G9.10",302,{"v":9e-93,"d":"9.00E-93"},"COG0078","pfam02729","OTCace_N","Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain.","GO:0000050|urea cycle;GO:0001889|liver development;GO:0006591|ornithine metabolic process;GO:0006593|ornithine catabolic process;GO:0007494|midgut development;GO:0009410|response to xenobiotic stimulus;GO:0010043|response to zinc ion;GO:0019240|citrulline biosynthetic process;GO:0031667|response to nutrient levels;GO:0032868|response to insulin;GO:0042450|arginine biosynthetic process via ornithine;GO:0055081|anion homeostasis;GO:0070781|response to biotin;GO:0097272|ammonia homeostasis;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0005759|mitochondrial matrix;GO:0043231|intracellular membrane-bounded organelle;","GO:0004585|ornithine carbamoyltransferase activity;GO:0005543|phospholipid binding;GO:0016597|amino acid binding;GO:0042301|phosphate ion binding;GO:0042802|identical protein binding;","K00611","OTC, argF, argI; ornithine carbamoyltransferase [EC:2.1.3.3]"]
["ENSRNOG00000024073",16,1.029287011,5,0.322809298,3.188529626,1.672891286,0.014199627,0.007412345,"up","yes","Syce1","protein_coding","chr1:195852172-195863174:-","gi|224451138|ref|NP_001020229.2|",1410,0,"synaptonemal complex central element protein 1 [Rattus norvegicus]","gi|224451137|ref|NM_001025058.2|",1446,0,"Rattus norvegicus synaptonemal complex central element protein 1 (Syce1), mRNA","Q5XHZ2",547,0,"Synaptonemal complex central element protein 1",".",".",".",".","pfam15233","SYCE1","Synaptonemal complex central element protein 1. This family of proteins includes synaptonemal complex central element protein 1, a component of the synaptonemal complex involved in meiosis, and synaptonemal complex central element protein 1-like, which may be involved in meiosis.","GO:0007130|synaptonemal complex assembly;GO:0051301|cell division;","GO:0000795|synaptonemal complex;GO:0000801|central element;GO:0005654|nucleoplasm;GO:0005694|chromosome;GO:0005829|cytosol;GO:0043231|intracellular membrane-bounded organelle;",".","K19534","SYCE1; synaptonemal complex central element protein 1"]
["ENSRNOG00000014702",21,1.350939202,8,0.516494877,2.615590708,1.387136803,0.014377261,7.500273E-3,"up","yes","Elovl2","protein_coding","chr17:23544568-23584848:+","gi|532023594|ref|XP_005355137.1|",1506,0,"PREDICTED: elongation of very long chain fatty acids protein 2 [Microtus ochrogaster]","gi|672081513|ref|XM_006253779.2|",3607,0,"PREDICTED: Rattus norvegicus ELOVL fatty acid elongase 2 (Elovl2), transcript variant X1, mRNA","D4A612",580,0,"Elongation of very long chain fatty acids protein 2",".",".",".",".","pfam01151","ELO","GNS1/SUR4 family. Members of this family are involved in long chain fatty acid elongation systems that produce the 26-carbon precursors for ceramide and sphingolipid synthesis. Predicted to be integral membrane proteins, in eukaryotes they are probably located on the endoplasmic reticulum. Yeast ELO3 affects plasma membrane H+-ATPase activity, and may act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1.","GO:0000038|very long-chain fatty acid metabolic process;GO:0006636|unsaturated fatty acid biosynthetic process;GO:0019367|fatty acid elongation, saturated fatty acid;GO:0030148|sphingolipid biosynthetic process;GO:0034625|fatty acid elongation, monounsaturated fatty acid;GO:0034626|fatty acid elongation, polyunsaturated fatty acid;GO:0042761|very long-chain fatty acid biosynthetic process;","GO:0005783|endoplasmic reticulum;GO:0030176|integral component of endoplasmic reticulum membrane;","GO:0009922|fatty acid elongase activity;GO:0016747|transferase activity, transferring acyl groups other than amino-acyl groups;GO:0102336|3-oxo-arachidoyl-CoA synthase activity;GO:0102337|3-oxo-cerotoyl-CoA synthase activity;GO:0102338|3-oxo-lignoceronyl-CoA synthase activity;GO:0102756|very-long-chain 3-ketoacyl-CoA synthase activity;","K10205","ELOVL2; elongation of very long chain fatty acids protein 2 [EC:2.3.1.199]"]
["ENSRNOG00000025235",21,1.350939202,8,0.516494877,2.615590708,1.387136803,0.014377261,7.500273E-3,"up","yes","Tmem130","protein_coding","chr12:9837055-9862840:+","gi|281371438|ref|NP_001163870.1|",2264,0,"transmembrane protein 130 precursor [Rattus norvegicus]","gi|281371437|ref|NM_001170399.1|",2755,0,"Rattus norvegicus transmembrane protein 130 (Tmem130), mRNA","Q6NXM3",788,0,"Transmembrane protein 130",".",".",".",".","pfam00801","PKD","PKD domain. This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.",".","GO:0005794|Golgi apparatus;GO:0005887|integral component of plasma membrane;",".",".","."]
["ENSRNOG00000004918",30,1.929913146,14,0.903866035,2.135176089,1.094355054,0.015174624,0.007885268,"up","yes","Kcna4","protein_coding","chr3:93756446-93769162:+","gi|564342168|ref|XP_006234735.1|",2506,0,"PREDICTED: potassium voltage-gated channel subfamily A member 4 isoform X1 [Rattus norvegicus]","gi|755498782|ref|XM_006498812.2|",6020,0,"PREDICTED: Mus musculus potassium voltage-gated channel, shaker-related subfamily, member 4 (Kcna4), transcript variant X1, mRNA","Q61423",967,0,"Potassium voltage-gated channel subfamily A member 4","MA2034",70.9,{"v":7e-12,"d":"7.00E-12"},"COG1226","pfam02214","BTB_2","BTB/POZ domain. In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.","GO:0006813|potassium ion transport;GO:0034765|regulation of ion transmembrane transport;GO:0051260|protein homooligomerization;GO:0071805|potassium ion transmembrane transport;","GO:0005783|endoplasmic reticulum;GO:0005887|integral component of plasma membrane;GO:0008076|voltage-gated potassium channel complex;GO:0009986|cell surface;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0032279|asymmetric synapse;GO:0043197|dendritic spine;GO:0043198|dendritic shaft;GO:0098978|glutamatergic synapse;GO:0099055|integral component of postsynaptic membrane;GO:0099056|integral component of presynaptic membrane;","GO:0005216|ion channel activity;GO:0005249|voltage-gated potassium channel activity;GO:0005251|delayed rectifier potassium channel activity;GO:0005267|potassium channel activity;GO:0005515|protein binding;GO:0030955|potassium ion binding;","K04877","KCNA4, KV1.4; potassium voltage-gated channel Shaker-related subfamily A member 4"]
["ENSRNOG00000060843",30,1.929913146,14,0.903866035,2.135176089,1.094355054,0.015174624,0.007885268,"up","yes","AABR07061385.2","protein_coding","chr4:121605127-121610076:+","gi|74193754|dbj|BAE22814.1|",322,{"v":1e-32,"d":"1.00E-32"},"unnamed protein product [Mus musculus]","gi|652700236|ref|NR_121593.1|",314,{"v":1E-161,"d":"1.00E-161"},"Mus musculus predicted gene 1965 (Gm1965), transcript variant 1, long non-coding RNA",".",".",".",".",".",".",".",".","pfam11282","DUF3082","Protein of unknown function (DUF3082). This family of proteins has no known function.",".",".",".",".","."]
["ENSRNOG00000064401",30,1.929913146,14,0.903866035,2.135176089,1.094355054,0.015174624,0.007885268,"up","yes","ENSRNOG00000064401","lncRNA","chr7:113445610-113451983:-",".",".",".",".","gi|672022155|ref|XR_348124.2|",649,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102549144 (LOC102549144), transcript variant X1, ncRNA",".",".",".",".",".",".",".",".","pfam08975","2H-phosphodiest","Domain of unknown function (DUF1868). This group of 2H-phosphodiesterases comprises a single family typified by the protein mlr3352 from M.loti. Members are also present in various alpha-proteobacteria, Synechocystis, Streptococcus and Chilo iridescent virus. The presence of a member of this predominantly bacterial group in a large eukaryotic DNA virus represents a potential case of horizontal transfer from a bacterial source into a virus. Several proteins of bacterial origin have been noticed in the insect viruses (L.M.Iyer, E.V.Koonin and L.Aravind, unpublished observations and these appear to have been acquired from endo-symbiotic or parasitic bacteria that share the same host cells with the viruses. Presence of 2H proteins in the proteomes of large DNA viruses (e.g. T4 57B protein and the Fowl-pox virus FPV025) may point to some role for these proteins in regulating the viral tRNA metabolizm. Each member of this family contains an internal duplication, each of which contains an HXTX motif that defines the family.",".",".",".",".","."]
["ENSRNOG00000000274",24,1.543930516,10,0.645618597,2.391397219,1.257853786,0.015242033,0.007918134,"up","yes","Phyhipl","protein_coding","chr20:18024666-18065478:+","gi|564397621|ref|XP_006256409.1|",1949,0,"PREDICTED: phytanoyl-CoA hydroxylase-interacting protein-like isoform X1 [Rattus norvegicus]","gi|672086224|ref|XM_006256347.2|",1639,0,"PREDICTED: Rattus norvegicus phytanoyl-CoA 2-hydroxylase interacting protein-like (Phyhipl), transcript variant X1, mRNA","Q6AYN4",753,0,"Phytanoyl-CoA hydroxylase-interacting protein-like",".",".",".",".","pfam00041","fn3","Fibronectin type III domain.",".","GO:0005737|cytoplasm;",".","K24497","PHYHIP; phytanoyl-CoA hydroxylate-interacting protein"]
["ENSRNOG00000001860",14,0.900626135,4,0.258247439,3.487454278,1.802174303,0.015678211,0.008124773,"up","yes","Ccdc116","protein_coding","chr11:83845557-83850607:+","gi|568996538|ref|XP_006522770.1|",2543,0,"PREDICTED: coiled-coil domain-containing protein 116 isoform X2 [Mus musculus]","gi|755554208|ref|XM_006522710.2|",1405,0,"PREDICTED: Mus musculus coiled-coil domain containing 116 (Ccdc116), transcript variant X5, mRNA","Q4V8B5",775,0,"Coiled-coil domain-containing protein 116",".",".",".",".","pfam10277","Frag1","Frag1/DRAM/Sfk1 family. This family includes Frag1, DRAM and Sfk1 proteins. Frag1 (FGF receptor activating protein 1) is a protein that is conserved from fungi to humans. There are four potential iso-prenylation sites throughout the peptide, viz CILW, CIIW and CIGL. Frag1 is a membrane-spanning protein that is ubiquitously expressed in adult tissues suggesting an important cellular function. Dram is a family of proteins conserved from nematodes to humans with six hydrophobic transmembrane regions and an Endoplasmic Reticulum signal peptide. It is a lysosomal protein that induces macro-autophagy as an effector of p53-mediated death, where p53 is the tumor-suppressor gene that is frequently mutated in cancer. Expression of Dram is stress-induced. This region is also part of a family of small plasma membrane proteins, referred to as Sfk1, that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, thus allowing proper localisation of Stt4p to the actin cytoskeleton.",".","GO:0005737|cytoplasm;GO:0005813|centrosome;",".",".","."]
["ENSRNOG00000003756",14,0.900626135,4,0.258247439,3.487454278,1.802174303,0.015678211,0.008124773,"up","yes","ENSRNOG00000003756","protein_coding","chrX:13480311-13609678:-","gi|300795244|ref|NP_001178657.1|",2146,0,"lanC-like protein 3 [Rattus norvegicus]","gi|238637327|ref|NM_173414.3|",1354,0,"Mus musculus LanC lantibiotic synthetase component C-like 3 (bacterial) (Lancl3), mRNA","Q6ZV70",817,0,"LanC-like protein 3",".",".",".",".","pfam05147","LANC_like","Lanthionine synthetase C-like protein. Lanthionines are thioether bridges that are putatively generated by dehydration of Ser and Thr residues followed by addition of cysteine residues within the peptide. This family contains the lanthionine synthetase C-like proteins 1 and 2 which are related to the bacterial lanthionine synthetase components C (LanC). LANCL1 (P40 seven-transmembrane-domain protein) and LANCL2 (testes-specific adriamycin sensitivity protein) are thought to be peptide-modifying enzyme components in eukaryotic cells. Both proteins are produced in large quantities in the brain and testes and may have role in the immune surveillance of these organs. Lanthionines are found in lantibiotics, which are peptide-derived, post-translationally modified antimicrobials produced by several bacterial strains. This region contains seven internal repeats.","GO:0005975|carbohydrate metabolic process;","GO:0005886|plasma membrane;",".",".","."]
["ENSRNOG00000029197",14,0.900626135,4,0.258247439,3.487454278,1.802174303,0.015678211,0.008124773,"up","yes","Diablo","protein_coding","chr12:33055263-33070387:+","gi|564306161|ref|XP_002726674.2|",969,{"v":1e-121,"d":"1.00E-121"},"PREDICTED: diablo homolog, mitochondrial-like isoform X1 [Rattus norvegicus]","gi|56605641|ref|NM_001008292.1|",1290,0,"Rattus norvegicus diablo, IAP-binding mitochondrial protein (Diablo), mRNA","Q9JIQ3",339,{"v":5E-110,"d":"5.00E-110"},"Diablo homolog, mitochondrial",".",".",".",".","pfam09057","Smac_DIABLO","Second Mitochondria-derived Activator of Caspases. Second Mitochondria-derived Activator of Caspases promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway, and by opposing the inhibitory activity of inhibitor of apoptosis proteins (XIAP-BIR3). The protein assumes an elongated three-helix bundle structure, and forms a dimer in solution.","GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0008631|intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0008635|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c;GO:0043065|positive regulation of apoptotic process;GO:0051402|neuron apoptotic process;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;GO:0009898|cytoplasmic side of plasma membrane;GO:0035631|CD40 receptor complex;",".","K10522","DIABLO, SMAC; diablo"]
["ENSRNOG00000064437",14,0.900626135,4,0.258247439,3.487454278,1.802174303,0.015678211,0.008124773,"up","yes","ENSRNOG00000064437","protein_coding","chr1:7184991-7188111:-","gi|126352304|ref|NP_001075250.1|",827,{"v":3E-152,"d":"3.00E-152"},"elongation factor 1-alpha 1 [Equus caballus]","gi|672088889|ref|XR_597813.1|",992,0,"PREDICTED: Rattus norvegicus eukaryotic translation elongation factor 1 alpha 1-like (LOC100360413), misc_RNA","A2Q0Z0",323,{"v":8e-154,"d":"8.00E-154"},"Elongation factor 1-alpha 1","SPCC794.09c",272,{"v":1e-118,"d":"1.00E-118"},"COG5256","pfam03143","GTP_EFTU_D3","Elongation factor Tu C-terminal domain. Elongation factor Tu consists of three structural domains, this is the third domain. This domain adopts a beta barrel structure. This the third domain is involved in binding to both charged tRNA and binding to EF-Ts pfam00889.",".",".",".",".","."]
["ENSRNOG00000069787",14,0.900626135,4,0.258247439,3.487454278,1.802174303,0.015678211,0.008124773,"up","yes","ENSRNOG00000069787","lncRNA","chr3:62277369-62278419:-","gi|742177570|ref|XP_010851909.1|",630,{"v":8e-128,"d":"8.00E-128"},"PREDICTED: ribosome biogenesis protein NSA2 homolog [Bison bison bison]","gi|68534731|gb|BC098657.1|",881,0,"Rattus norvegicus CDK105 protein, mRNA (cDNA clone MGC:112601 IMAGE:7378282), complete cds","Q3SX11",245,{"v":7e-129,"d":"7.00E-129"},"Ribosome biogenesis protein NSA2 homolog","SPCP1E11.08",197,{"v":1E-59,"d":"1.00E-59"},"COG2007","pfam01201","Ribosomal_S8e","Ribosomal protein S8e.",".",".",".",".","."]
["ENSRNOG00000009033",10,0.643304382,2,0.129123719,4.98207754,2.316747476,0.016336776,0.008433151,"up","yes","Cntn2","protein_coding","chr13:43947265-43975887:-","gi|564380454|ref|XP_006249808.1|",5257,0,"PREDICTED: contactin-2 isoform X1 [Rattus norvegicus]","gi|672073641|ref|XM_008769427.1|",5024,0,"PREDICTED: Rattus norvegicus contactin 2 (axonal) (Cntn2), transcript variant X2, mRNA","P22063",2024,0,"Contactin-2",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0000226|microtubule cytoskeleton organization;GO:0001764|neuron migration;GO:0007160|cell-matrix adhesion;GO:0007409|axonogenesis;GO:0007411|axon guidance;GO:0007413|axonal fasciculation;GO:0007612|learning;GO:0007628|adult walking behavior;GO:0010769|regulation of cell morphogenesis involved in differentiation;GO:0010954|positive regulation of protein processing;GO:0021853|cerebral cortex GABAergic interneuron migration;GO:0022010|central nervous system myelination;GO:0031133|regulation of axon diameter;GO:0031175|neuron projection development;GO:0031623|receptor internalization;GO:0045163|clustering of voltage-gated potassium channels;GO:0045665|negative regulation of neuron differentiation;GO:0048168|regulation of neuronal synaptic plasticity;GO:0048710|regulation of astrocyte differentiation;GO:0060168|positive regulation of adenosine receptor signaling pathway;GO:0071205|protein localization to juxtaparanode region of axon;GO:0071206|establishment of protein localization to juxtaparanode region of axon;GO:0097090|presynaptic membrane organization;","GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0030424|axon;GO:0033268|node of Ranvier;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043209|myelin sheath;GO:0044224|juxtaparanode region of axon;GO:0045202|synapse;GO:0099025|anchored component of postsynaptic membrane;","GO:0030246|carbohydrate binding;GO:0043621|protein self-association;","K06760","CNTN2; contactin 2"]
["ENSRNOG00000020245",10,0.643304382,2,0.129123719,4.98207754,2.316747476,0.016336776,0.008433151,"up","yes","Syt8","protein_coding","chr1:197590149-197593504:+","gi|149061706|gb|EDM12129.1|",1820,0,"synaptotagmin 8, isoform CRA_b [Rattus norvegicus]","gi|14210275|gb|AF375467.1|AF375467",1173,0,"Rattus norvegicus synaptotagmin 8 mRNA, complete cds","Q925B4",697,0,"Synaptotagmin-8",".",".",".",".","pfam00168","C2","C2 domain.","GO:0006887|exocytosis;GO:0007340|acrosome reaction;GO:0014059|regulation of dopamine secretion;GO:0016192|vesicle-mediated transport;GO:0017156|calcium ion regulated exocytosis;GO:0017158|regulation of calcium ion-dependent exocytosis;GO:0048488|synaptic vesicle endocytosis;GO:0048791|calcium ion-regulated exocytosis of neurotransmitter;GO:0071277|cellular response to calcium ion;","GO:0001669|acrosomal vesicle;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0030672|synaptic vesicle membrane;GO:0031045|dense core granule;GO:0031982|vesicle;GO:0070382|exocytic vesicle;","GO:0000149|SNARE binding;GO:0001786|phosphatidylserine binding;GO:0005509|calcium ion binding;GO:0030276|clathrin binding;GO:0048306|calcium-dependent protein binding;","K19908","SYT8; synaptotagmin-8"]
["ENSRNOG00000026745",10,0.643304382,2,0.129123719,4.98207754,2.316747476,0.016336776,0.008433151,"up","yes","Acsl6","protein_coding","chr10:38440080-38498757:+","gi|564371650|ref|XP_006246283.1|",4095,0,"PREDICTED: long-chain-fatty-acid--CoA ligase 6 isoform X1 [Rattus norvegicus]","gi|672067212|ref|XM_006246221.2|",2719,0,"PREDICTED: Rattus norvegicus acyl-CoA synthetase long-chain family member 6 (Acsl6), transcript variant X1, mRNA","P33124",1418,0,"Long-chain-fatty-acid--CoA ligase 6","YER015w",310,{"v":5E-91,"d":"5.00E-91"},"COG1022","pfam00501","AMP-binding","AMP-binding enzyme.","GO:0000038|very long-chain fatty acid metabolic process;GO:0001666|response to hypoxia;GO:0001676|long-chain fatty acid metabolic process;GO:0007405|neuroblast proliferation;GO:0007584|response to nutrient;GO:0008610|lipid biosynthetic process;GO:0008654|phospholipid biosynthetic process;GO:0009629|response to gravity;GO:0010747|positive regulation of plasma membrane long-chain fatty acid transport;GO:0010976|positive regulation of neuron projection development;GO:0015908|fatty acid transport;GO:0019432|triglyceride biosynthetic process;GO:0032869|cellular response to insulin stimulus;GO:0035338|long-chain fatty-acyl-CoA biosynthetic process;GO:0048545|response to steroid hormone;GO:0048666|neuron development;","GO:0005634|nucleus;GO:0005741|mitochondrial outer membrane;GO:0005778|peroxisomal membrane;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0004467|long-chain fatty acid-CoA ligase activity;GO:0005524|ATP binding;GO:0019899|enzyme binding;GO:0042803|protein homodimerization activity;GO:0047676|arachidonate-CoA ligase activity;","K01897","ACSL, fadD; long-chain acyl-CoA synthetase [EC:6.2.1.3]"]
["ENSRNOG00000033983",10,0.643304382,2,0.129123719,4.98207754,2.316747476,0.016336776,0.008433151,"up","yes","Sohlh1","protein_coding","chr3:8663318-8667388:-","gi|300797768|ref|NP_001178781.1|",1622,0,"spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1 [Rattus norvegicus]","gi|300797767|ref|NM_001191852.1|",1074,0,"Rattus norvegicus spermatogenesis and oogenesis specific basic helix-loop-helix 1 (Sohlh1), mRNA","Q6IUP1",551,0,"Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1",".",".",".",".","pfam03154","Atrophin-1","Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.","GO:0001541|ovarian follicle development;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007283|spermatogenesis;GO:0009994|oocyte differentiation;GO:0010468|regulation of gene expression;GO:0030154|cell differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048477|oogenesis;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0046982|protein heterodimerization activity;","K22495","SOHLH1; spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1"]
["ENSRNOG00000058009",10,0.643304382,2,0.129123719,4.98207754,2.316747476,0.016336776,0.008433151,"up","yes","SNORA70","snoRNA","chr11:44586288-44586425:+","gi|664730342|ref|XP_008522378.1|",120,3e-07,"PREDICTED: 60S ribosomal protein L10-like [Equus przewalskii]","gi|589968209|ref|XM_006996537.1|",118,{"v":8e-54,"d":"8.00E-54"},"PREDICTED: Peromyscus maniculatus bairdii tRNA methyltransferase 10 homolog C (S. cerevisiae) (Trmt10c), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam00777","Glyco_transf_29","Glycosyltransferase family 29 (sialyltransferase). Members of this family belong to glycosyltransferase family 29.",".",".",".",".","."]
["ENSRNOG00000000618",12,0.771965258,3,0.193685579,3.985662032,1.994819381,0.016624219,0.008564501,"up","yes","Mdga2","protein_coding","chr6:84761941-85608126:-","gi|74200521|dbj|BAE23453.1|",5108,0,"unnamed protein product [Mus musculus]","gi|672056215|ref|XM_008764688.1|",3090,0,"PREDICTED: Rattus norvegicus MAM domain containing glycosylphosphatidylinositol anchor 2 (Mdga2), transcript variant X1, mRNA","Q7Z553",1916,0,"MAM domain-containing glycosylphosphatidylinositol anchor protein 2",".",".",".",".","pfam00629","MAM","MAM domain. An extracellular domain found in many receptors.","GO:0001764|neuron migration;GO:0007389|pattern specification process;GO:0021522|spinal cord motor neuron differentiation;GO:0099179|regulation of synaptic membrane adhesion;GO:1905606|regulation of presynapse assembly;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0031225|anchored component of membrane;GO:0098978|glutamatergic synapse;GO:0098982|GABA-ergic synapse;",".",".","."]
["ENSRNOG00000002484",12,0.771965258,3,0.193685579,3.985662032,1.994819381,0.016624219,0.008564501,"up","yes","Chrna9","protein_coding","chr14:42235226-42242192:-","gi|68067466|sp|P43144.2|ACHA9_RAT",2455,0,"RecName: Full=Neuronal acetylcholine receptor subunit alpha-9; AltName: Full=Nicotinic acetylcholine receptor subunit alpha-9; Short=NACHR alpha-9; Flags: Precursor","gi|12621087|ref|NM_022930.1|",1769,0,"Rattus norvegicus cholinergic receptor nicotinic alpha 9 subunit (Chrna9), mRNA","P43144",950,0,"Neuronal acetylcholine receptor subunit alpha-9",".",".",".",".","pfam02931","Neur_chan_LBD","Neurotransmitter-gated ion-channel ligand binding domain. This family is the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.","GO:0006812|cation transport;GO:0007165|signal transduction;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007268|chemical synaptic transmission;GO:0007605|sensory perception of sound;GO:0034220|ion transmembrane transport;GO:0042391|regulation of membrane potential;GO:0042472|inner ear morphogenesis;GO:0050877|nervous system process;GO:0050910|detection of mechanical stimulus involved in sensory perception of sound;GO:0060079|excitatory postsynaptic potential;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0070588|calcium ion transmembrane transport;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005892|acetylcholine-gated channel complex;GO:0043005|neuron projection;GO:0045202|synapse;GO:0098981|cholinergic synapse;GO:0099060|integral component of postsynaptic specialization membrane;","GO:0004888|transmembrane signaling receptor activity;GO:0005262|calcium channel activity;GO:0022848|acetylcholine-gated cation-selective channel activity;GO:0030594|neurotransmitter receptor activity;GO:1904315|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K04810","CHRNA9; nicotinic acetylcholine receptor alpha-9"]
["ENSRNOG00000016628",12,0.771965258,3,0.193685579,3.985662032,1.994819381,0.016624219,0.008564501,"up","yes","Scgn","protein_coding","chr17:41106467-41148667:+","gi|672081799|ref|XP_008769875.1|",1452,0,"PREDICTED: secretagogin isoform X1 [Rattus norvegicus]","gi|672081798|ref|XM_008771653.1|",1477,0,"PREDICTED: Rattus norvegicus secretagogin, EF-hand calcium binding protein (Scgn), transcript variant X1, mRNA","Q6R556",560,0,"Secretagogin",".",".",".",".","pfam13499","EF-hand_7","EF-hand domain pair.","GO:0051480|regulation of cytosolic calcium ion concentration;GO:0099509|regulation of presynaptic cytosolic calcium ion concentration;GO:1900271|regulation of long-term synaptic potentiation;","GO:0005576|extracellular region;GO:0005634|nucleus;GO:0005829|cytosol;GO:0030425|dendrite;GO:0030658|transport vesicle membrane;GO:0043005|neuron projection;GO:0043195|terminal bouton;GO:0045202|synapse;","GO:0005509|calcium ion binding;","K23928","SCGN; secretagogin"]
["ENSRNOG00000064689",12,0.771965258,3,0.193685579,3.985662032,1.994819381,0.016624219,0.008564501,"up","yes","ENSRNOG00000064689","lncRNA","chr8:99216863-99239322:+",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","pfam00967","Barwin","Barwin family.",".",".",".",".","."]
["ENSRNOG00000066139",12,0.771965258,3,0.193685579,3.985662032,1.994819381,0.016624219,0.008564501,"up","yes","ENSRNOG00000066139","pseudogene","chr7:12662391-12664176:-","gi|56090329|ref|NP_001007652.1|",763,{"v":1E-97,"d":"1.00E-97"},"peflin [Rattus norvegicus]","gi|56090328|ref|NM_001007651.1|",262,{"v":5e-133,"d":"5.00E-133"},"Rattus norvegicus penta-EF hand domain containing 1 (Pef1), mRNA","Q641Z8",298,{"v":3e-99,"d":"3.00E-99"},"Peflin",".",".",".",".","pfam13499","EF-hand_7","EF-hand domain pair.",".",".",".",".","."]
["ENSRNOG00000020985",19,1.222278326,7,0.451933018,2.704556379,1.435391972,0.016887158,0.008690556,"up","yes","Atp4a","protein_coding","chr1:85961708-85974844:+","gi|281306811|ref|NP_036641.1|",5271,0,"potassium-transporting ATPase alpha chain 1 [Rattus norvegicus]","gi|203036|gb|J02649.1|RATATPAST",3383,0,"Rat stomach (H+,K+)-ATPase mRNA, complete cds","P09626",2027,0,"Potassium-transporting ATPase alpha chain 1","MA4378",627,0,"COG0474","pfam00122","E1-E2_ATPase","E1-E2 ATPase.","GO:0001696|gastric acid secretion;GO:0006883|cellular sodium ion homeostasis;GO:0009410|response to xenobiotic stimulus;GO:0010155|regulation of proton transport;GO:0010248|establishment or maintenance of transmembrane electrochemical gradient;GO:0030007|cellular potassium ion homeostasis;GO:0036376|sodium ion export across plasma membrane;GO:0045851|pH reduction;GO:0071805|potassium ion transmembrane transport;GO:1902600|proton transmembrane transport;GO:1990573|potassium ion import across plasma membrane;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;","GO:0000287|magnesium ion binding;GO:0005391|sodium:potassium-exchanging ATPase activity;GO:0005524|ATP binding;GO:0008900|potassium:proton exchanging ATPase activity;GO:0030955|potassium ion binding;","K01542","ATP4A; H+/K+-exchanging ATPase subunit alpha [EC:7.2.2.19]"]
["ENSRNOG00000051867",19,1.222278326,7,0.451933018,2.704556379,1.435391972,0.016887158,0.008690556,"up","yes","Zfp758","protein_coding","chr1:61942116-61989490:-","gi|564296578|ref|XP_006223031.1|",3394,0,"PREDICTED: zinc finger protein 260-like [Rattus norvegicus]","gi|672070789|ref|XM_006228088.2|",2384,0,"PREDICTED: Rattus norvegicus zinc finger protein 758 (Zfp758), mRNA","A2VDQ7",596,0,"Zinc finger protein 420",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0016604|nuclear body;","GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0043565|sequence-specific DNA binding;GO:0046872|metal ion binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSRNOG00000027791",31,1.994243584,15,0.968427895,2.059258717,1.042125095,0.017697447,0.009078918,"up","yes","AABR07015346.1","protein_coding","chr14:51301168-51301633:+","gi|11968072|ref|NP_071948.1|",438,{"v":4e-53,"d":"4.00E-53"},"cytochrome c oxidase subunit 7A2, mitochondrial precursor [Rattus norvegicus]","gi|298905467|emb|FQ209801.1|",449,0,"Rattus norvegicus TL0ABA39YP13 mRNA sequence","P35171",173,{"v":1E-54,"d":"1.00E-54"},"Cytochrome c oxidase subunit 7A2, mitochondrial",".",".",".",".","pfam02238","COX7a","Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase, a 13 sub-unit complex, is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of the heart and liver isoforms of cytochrome c oxidase subunit VIIa.","GO:0006123|mitochondrial electron transport, cytochrome c to oxygen;","GO:0005751|mitochondrial respiratory chain complex IV;GO:0016021|integral component of membrane;","GO:0009055|electron transfer activity;","K02270","COX7A; cytochrome c oxidase subunit 7a"]
["ENSRNOG00000067832",31,1.994243584,15,0.968427895,2.059258717,1.042125095,0.017697447,0.009078918,"up","yes","ENSRNOG00000067832","protein_coding","chr3:145431037-145454326:-","gi|62078575|ref|NP_001013945.1|",1583,0,"protein NDRG3 [Rattus norvegicus]","gi|62078574|ref|NM_001013923.1|",2340,0,"Rattus norvegicus NDRG family member 3 (Ndrg3), mRNA","Q6AYR2",614,0,"Protein NDRG3",".",".",".",".","pfam03096","Ndr","Ndr family. This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, and Ndr3. Their similarity was previously noted. The precise molecular and cellular function of members of this family is still unknown. Yet, they are known to be involved in cellular differentiation events. The Ndr1 group was the first to be discovered. Their expression is repressed by the proto-oncogenes N-myc and c-myc, and in line with this observation, Ndr1 protein expression is down-regulated in neoplastic cells, and is reactivated when differentiation is induced by chemicals such as retinoic acid. Ndr2 and Ndr3 expression is not under the control of N-myc or c-myc. Ndr1 expression is also activated by several chemicals: tunicamycin and homocysteine induce Ndr1 in human umbilical endothelial cells; nickel induces Ndr1 in several cell types. Members of this family are found in wide variety of multicellular eukaryotes, including an Ndr1 type protein in Helianthus annuus (sunflower), known as Sf21. Interestingly, the highest scoring matches in the noise are all alpha/beta hydrolases pfam00561, suggesting that this family may have an enzymatic function (Bateman A pers. obs.).",".",".",".",".","."]
["ENSRNOG00000002636",22,1.41526964,9,0.581056737,2.435682353,1.284325998,0.018210614,0.009323752,"up","yes","Abat","protein_coding","chr10:6999819-7092835:-","gi|564370487|ref|XP_006245822.1|",2709,0,"PREDICTED: 4-aminobutyrate aminotransferase, mitochondrial isoform X1 [Rattus norvegicus]","gi|402743899|ref|NM_031003.2|",1713,0,"Rattus norvegicus 4-aminobutyrate aminotransferase (Abat), mRNA","P50554",1048,0,"4-aminobutyrate aminotransferase, mitochondrial","SPAC19D5.07",403,{"v":2e-133,"d":"2.00E-133"},"COG0160","pfam00202","Aminotran_3","Aminotransferase class-III.","GO:0001666|response to hypoxia;GO:0007568|aging;GO:0007620|copulation;GO:0007626|locomotory behavior;GO:0009410|response to xenobiotic stimulus;GO:0009448|gamma-aminobutyric acid metabolic process;GO:0009449|gamma-aminobutyric acid biosynthetic process;GO:0009450|gamma-aminobutyric acid catabolic process;GO:0010039|response to iron ion;GO:0014053|negative regulation of gamma-aminobutyric acid secretion;GO:0021549|cerebellum development;GO:0031652|positive regulation of heat generation;GO:0032024|positive regulation of insulin secretion;GO:0033602|negative regulation of dopamine secretion;GO:0035094|response to nicotine;GO:0035640|exploration behavior;GO:0042135|neurotransmitter catabolic process;GO:0042220|response to cocaine;GO:0045471|response to ethanol;GO:0045776|negative regulation of blood pressure;GO:0045964|positive regulation of dopamine metabolic process;GO:0048148|behavioral response to cocaine;GO:0070474|positive regulation of uterine smooth muscle contraction;GO:0090331|negative regulation of platelet aggregation;GO:0097151|positive regulation of inhibitory postsynaptic potential;GO:1902722|positive regulation of prolactin secretion;GO:1904450|positive regulation of aspartate secretion;","GO:0005739|mitochondrion;GO:0005759|mitochondrial matrix;GO:0032144|4-aminobutyrate transaminase complex;GO:0043005|neuron projection;","GO:0003867|4-aminobutyrate transaminase activity;GO:0030170|pyridoxal phosphate binding;GO:0032145|succinate-semialdehyde dehydrogenase binding;GO:0034386|4-aminobutyrate:2-oxoglutarate transaminase activity;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0046872|metal ion binding;GO:0047298|(S)-3-amino-2-methylpropionate transaminase activity;GO:0051536|iron-sulfur cluster binding;","K13524","ABAT; 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase [EC:2.6.1.19 2.6.1.22]"]
["ENSRNOG00000059624",22,1.41526964,9,0.581056737,2.435682353,1.284325998,0.018210614,0.009323752,"up","yes","AABR07015889.1","protein_coding","chr14:78776373-78776700:+","gi|533160022|ref|XP_005393885.1|",368,{"v":5e-44,"d":"5.00E-44"},"PREDICTED: transcription initiation factor IIA subunit 2 [Chinchilla lanigera]","gi|918613380|ref|XM_005393828.2|",153,{"v":5e-73,"d":"5.00E-73"},"PREDICTED: Chinchilla lanigera general transcription factor IIA, 2, 12kDa (Gtf2a2), mRNA","P52657",130,{"v":9e-39,"d":"9.00E-39"},"Transcription initiation factor IIA subunit 2","SPCC553.11c",57.8,{"v":3E-11,"d":"3.00E-11"},"COG5123","pfam02751","TFIIA_gamma_C","Transcription initiation factor IIA, gamma subunit. Accurate transcription in vivo requires at least six general transcription initiation factors, in addition to RNA polymerase II. Transcription initiation factor IIA (TFIIA) is a multimeric protein which facilitates the binding of TFIID to the TATA box. The C-terminal domain of the gamma subunit is a 12 stranded beta-barrel.",".",".",".",".","."]
["ENSRNOG00000004112",6,0.385982629,0,0.03228093,11.9569861,3.579781881,0.020936565,0.010565047,"up","yes","RGD1308775","protein_coding","chr14:78781315-78789956:-","gi|157821851|ref|NP_001100703.1|",882,{"v":7e-110,"d":"7.00E-110"},"uncharacterized protein C5orf52 homolog [Rattus norvegicus]","gi|157821850|ref|NM_001107233.1|",2518,0,"Rattus norvegicus similar to RIKEN cDNA 4921536K21 (RGD1308775), mRNA",".",".",".",".",".",".",".",".","pfam11561","Saw1","Single strand annealing-weakened 1. This family of yeast proteins is involved in single-strand-annealing, or SSA. SSA entails multiple steps: end resection and ssDNA formation; annealing of complementary ssDNAs; removal of 3' single-stranded non-homologous tails; gap fill-in synthesis; and ligation. Saw1 in combination with Slx4 catalyses the 3' non-homologous tail removal during recombination. Saw1 interacts physically with Rad1/Rad10, Msh2/Msh3, and Rad52 proteins, and works by targeting Rad1/Rad10 to Rad52-coated recombination intermediates.",".",".",".",".","."]
["ENSRNOG00000012195",6,0.385982629,0,0.03228093,11.9569861,3.579781881,0.020936565,0.010565047,"up","yes","Tas2r108","protein_coding","chr4:69287667-69288581:+","gi|67010021|ref|NP_001019857.1|",1347,0,"taste receptor type 2 member 4 [Rattus norvegicus]","gi|67010020|ref|NM_001024686.1|",915,0,"Rattus norvegicus taste receptor, type 2, member 108 (Tas2r108), mRNA","Q67ET0",523,0,"Taste receptor type 2 member 4",".",".",".",".","pfam05296","TAS2R","Mammalian taste receptor protein (TAS2R). This family consists of several forms of mammalian taste receptor proteins (TAS2Rs). TAS2Rs are G protein-coupled receptors expressed in subsets of taste receptor cells of the tongue and palate epithelia and are organized in the genome in clusters. The proteins are genetically linked to loci that influence bitter perception in mice and humans.","GO:0001580|detection of chemical stimulus involved in sensory perception of bitter taste;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007585|respiratory gaseous exchange;","GO:0016021|integral component of membrane;GO:0060170|ciliary membrane;","GO:0004930|G protein-coupled receptor activity;GO:0033038|bitter taste receptor activity;","K08474","TAS2R; taste receptor type 2"]
["ENSRNOG00000018215",6,0.385982629,0,0.03228093,11.9569861,3.579781881,0.020936565,0.010565047,"up","yes","Slc22a6","protein_coding","chr1:205522729-205531173:+","gi|8393886|ref|NP_058920.1|",2855,0,"solute carrier family 22 member 6 [Rattus norvegicus]","gi|2361034|dbj|AB004559.1|",2209,0,"Rattus norvegicus mRNA for multispecific organic anion transporter, complete cds","O35956",1101,0,"Solute carrier family 22 member 6",".",".",".",".","pfam00083","Sugar_tr","Sugar (and other) transporter.","GO:0006820|anion transport;GO:0015698|inorganic anion transport;GO:0015711|organic anion transport;GO:0015742|alpha-ketoglutarate transport;GO:0031427|response to methotrexate;GO:0043252|sodium-independent organic anion transport;GO:0097254|renal tubular secretion;GO:0098656|anion transmembrane transport;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005901|caveola;GO:0016323|basolateral plasma membrane;GO:0032991|protein-containing complex;","GO:0005452|inorganic anion exchanger activity;GO:0005515|protein binding;GO:0008514|organic anion transmembrane transporter activity;GO:0015301|anion:anion antiporter activity;GO:0015347|sodium-independent organic anion transmembrane transporter activity;GO:0031404|chloride ion binding;GO:0042802|identical protein binding;","K08203","SLC22A6, OAT1; MFS transporter, OCT family, solute carrier family 22 (organic anion transporter), member 6"]
["ENSRNOG00000024093",6,0.385982629,0,0.03228093,11.9569861,3.579781881,0.020936565,0.010565047,"up","yes","Dmrta1","protein_coding","chr5:104415893-104422433:+","gi|157822065|ref|NP_001101415.1|",2163,0,"doublesex- and mab-3-related transcription factor A1 [Rattus norvegicus]","gi|157822064|ref|NM_001107945.1|",4030,0,"Rattus norvegicus DMRT-like family A1 (Dmrta1), mRNA","Q8CFG4",775,0,"Doublesex- and mab-3-related transcription factor A1",".",".",".",".","pfam00751","DM","DM DNA binding domain. The DM domain is named after dsx and mab-3. dsx contains a single amino-terminal DM domain, whereas mab-3 contains two amino-terminal domains. The DM domain has a pattern of conserved zinc chelating residues C2H2C4. The dsx DM domain has been shown to dimerise and bind palindromic DNA.","GO:0001541|ovarian follicle development;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007281|germ cell development;GO:0007548|sex differentiation;GO:0060179|male mating behavior;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0042802|identical protein binding;GO:0043565|sequence-specific DNA binding;GO:0046872|metal ion binding;GO:1990837|sequence-specific double-stranded DNA binding;","K19491","DMRT4_5, DMRTA; doublesex- and mab-3-related transcription factor 4/5"]
["ENSRNOG00000026675",6,0.385982629,0,0.03228093,11.9569861,3.579781881,0.020936565,0.010565047,"up","yes","ENSRNOG00000026675","protein_coding","chr4:121571797-121573140:+","gi|672018540|ref|XP_008774013.1|",915,{"v":6e-123,"d":"6.00E-123"},"PREDICTED: proline-rich protein 20A-like [Rattus norvegicus]","gi|672018539|ref|XM_008775791.1|",557,0,"PREDICTED: Rattus norvegicus hypothetical protein LOC685621 (LOC685621), mRNA",".",".",".",".",".",".",".",".","pfam05110","AF-4","AF-4 proto-oncoprotein. This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.",".",".","GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000026883",6,0.385982629,0,0.03228093,11.9569861,3.579781881,0.020936565,0.010565047,"up","yes","Smco2","protein_coding","chr4:179765442-179791066:+","gi|392340192|ref|XP_003754008.1|",1766,0,"PREDICTED: single-pass membrane and coiled-coil domain-containing protein 2 isoform X1 [Rattus norvegicus]","gi|672018928|ref|XM_008775870.1|",1251,0,"PREDICTED: Rattus norvegicus single-pass membrane protein with coiled-coil domains 2 (Smco2), transcript variant X2, mRNA","Q9DA21",535,0,"Single-pass membrane and coiled-coil domain-containing protein 2",".",".",".",".","pfam14992","TMCO5","TMCO5 family. The TMCO5 family includes human transmembrane and coiled-coil domain-containing proteins 5A and 5B.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000027908",6,0.385982629,0,0.03228093,11.9569861,3.579781881,0.020936565,0.010565047,"up","yes","Actrt3","protein_coding","chr2:112799011-112801075:+","gi|157822087|ref|NP_001102412.1|",1996,0,"actin-related protein T3 [Rattus norvegicus]","gi|157822086|ref|NM_001108942.1|",1116,0,"Rattus norvegicus actin-related protein T3 (Actrt3), mRNA","Q8BXF8",714,0,"Actin-related protein T3","YFL039c",395,{"v":4e-134,"d":"4.00E-134"},"COG5277","pfam00022","Actin","Actin.",".","GO:0001673|male germ cell nucleus;",".",".","."]
["ENSRNOG00000033981",6,0.385982629,0,0.03228093,11.9569861,3.579781881,0.020936565,0.010565047,"up","yes","ENSRNOG00000033981","protein_coding","chr8:34024114-34050517:+","gi|74195000|dbj|BAE26067.1|",609,{"v":3e-78,"d":"3.00E-78"},"unnamed protein product [Mus musculus]","gi|74194999|dbj|AK144787.1|",290,{"v":7e-149,"d":"7.00E-149"},"Mus musculus lung RCB-0558 LLC cDNA, RIKEN full-length enriched library, clone:G730034J08 product:hypothetical protein, full insert sequence","Q3UW31",173,{"v":2e-54,"d":"2.00E-54"},"Prostate and testis expressed protein 2",".",".",".",".","pfam00858","ASC","Amiloride-sensitive sodium channel.",".","GO:0005615|extracellular space;",".","K25370","PATE; prostate and testis expressed protein"]
["ENSRNOG00000037481",6,0.385982629,0,0.03228093,11.9569861,3.579781881,0.020936565,0.010565047,"up","yes","AC095390.1","protein_coding","chr12:45908683-45909048:-","gi|157819229|ref|NP_001100054.1|",600,{"v":1e-77,"d":"1.00E-77"},"replication protein A 14 kDa subunit [Rattus norvegicus]","gi|33342292|gb|AC095390.9|",366,0,"Rattus norvegicus 12 BAC CH230-7C24 (Children's Hospital Oakland Research Institute) complete sequence","Q9CQ71",222,{"v":8e-74,"d":"8.00E-74"},"Replication protein A 14 kDa subunit",".",".",".",".","pfam08661","Rep_fac-A_3","Replication factor A protein 3. Replication factor A is involved in eukaryotic DNA replication, recombination and repair.",".",".",".",".","."]
["ENSRNOG00000047175",6,0.385982629,0,0.03228093,11.9569861,3.579781881,0.020936565,0.010565047,"up","yes","Cryaa","pseudogene","chr20:9783605-9787349:+","gi|19526477|ref|NP_036666.2|",814,{"v":2e-105,"d":"2.00E-105"},"alpha-crystallin A chain isoform 1 [Rattus norvegicus]","gi|576583437|ref|NM_012534.4|",1060,0,"Rattus norvegicus crystallin, alpha A (Cryaa), transcript variant 1, mRNA","P68406",318,{"v":7e-107,"d":"7.00E-107"},"Alpha-crystallin A chain",".",".",".",".","pfam00011","HSP20","Hsp20/alpha crystallin family.","GO:0001666|response to hypoxia;GO:0001934|positive regulation of protein phosphorylation;GO:0002088|lens development in camera-type eye;GO:0002089|lens morphogenesis in camera-type eye;GO:0006457|protein folding;GO:0006915|apoptotic process;GO:0007005|mitochondrion organization;GO:0007015|actin filament organization;GO:0007017|microtubule-based process;GO:0007021|tubulin complex assembly;GO:0007601|visual perception;GO:0009410|response to xenobiotic stimulus;GO:0010259|multicellular organism aging;GO:0010288|response to lead ion;GO:0010629|negative regulation of gene expression;GO:0030307|positive regulation of cell growth;GO:0032387|negative regulation of intracellular transport;GO:0042542|response to hydrogen peroxide;GO:0043010|camera-type eye development;GO:0043066|negative regulation of apoptotic process;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0048596|embryonic camera-type eye morphogenesis;GO:0050821|protein stabilization;GO:0051384|response to glucocorticoid;GO:0060561|apoptotic process involved in morphogenesis;GO:0070141|response to UV-A;GO:0070309|lens fiber cell morphogenesis;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0032991|protein-containing complex;","GO:0005198|structural molecule activity;GO:0005212|structural constituent of eye lens;GO:0005515|protein binding;GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0051082|unfolded protein binding;","K09541","CRYAA; crystallin, alpha A"]
["ENSRNOG00000058811",6,0.385982629,0,0.03228093,11.9569861,3.579781881,0.020936565,0.010565047,"up","yes","U6","snRNA","chr17:67008651-67008754:+","gi|925678112|gb|KOX75182.1|",136,2e-09,"hypothetical protein WN51_12896 [Melipona quadrifasciata]","gi|953267268|ref|NG_045885.1|",80,{"v":7e-33,"d":"7.00E-33"},"Homo sapiens RNA, U6 small nuclear 558, pseudogene (RNU6-558P) on chromosome 12",".",".",".",".",".",".",".",".","pfam10240","DUF2464","Protein of unknown function (DUF2464). This is a family of proteins conserved from worms to humans. Members have been annotated as FAM125A proteins, but their function is unknown.",".",".",".",".","."]
["ENSRNOG00000062994",6,0.385982629,0,0.03228093,11.9569861,3.579781881,0.020936565,0.010565047,"up","yes","ENSRNOG00000062994","protein_coding","chrX:132703263-132703769:+","gi|109511234|ref|XP_228669.3|",681,{"v":2e-88,"d":"2.00E-88"},"PREDICTED: high mobility group protein B4-like [Rattus norvegicus]","gi|672033140|ref|XM_008758130.1|",507,0,"PREDICTED: Rattus norvegicus similar to RIKEN cDNA 1700001F22 (RGD1561558), mRNA","Q6P8W9",175,{"v":6e-54,"d":"6.00E-54"},"High mobility group protein B4","SPAC57A10.09c",47,1e-06,"COG5648","pfam00505","HMG_box","HMG (high mobility group) box.",".",".",".",".","."]
["ENSRNOG00000063934",6,0.385982629,0,0.03228093,11.9569861,3.579781881,0.020936565,0.010565047,"up","yes","ENSRNOG00000063934","lncRNA","chr17:17761256-17766039:-",".",".",".",".","gi|755544681|ref|XM_011244376.1|",142,{"v":1e-66,"d":"1.00E-66"},"PREDICTED: Mus musculus kinesin family member 13A (Kif13a), transcript variant X6, mRNA",".",".",".",".",".",".",".",".","pfam06607","Prokineticin","Prokineticin. This family consists of several prokineticin proteins and related BM8 sequences. The suprachiasmatic nucleus (SCN) controls the circadian rhythm of physiological and behavioural processes in mammals. It has been shown that prokineticin 2 (PK2), a cysteine-rich secreted protein, functions as an output molecule from the SCN circadian clock. PK2 messenger RNA is rhythmically expressed in the SCN, and the phase of PK2 rhythm is responsive to light entrainment. Molecular and genetic studies have revealed that PK2 is a gene that is controlled by a circadian clock.",".",".",".",".","."]
["ENSRNOG00000065574",6,0.385982629,0,0.03228093,11.9569861,3.579781881,0.020936565,0.010565047,"up","yes","Mug2","protein_coding","chr4:155164011-155236475:+","gi|50657404|ref|NP_001002826.1|",7196,0,"murinoglobulin-2 precursor [Rattus norvegicus]","gi|672050893|ref|XM_006237282.2|",2117,0,"PREDICTED: Rattus norvegicus murinoglobulin 1 (Mug1), transcript variant X1, mRNA","Q6IE52",2776,0,"Murinoglobulin-2","TM0984",72,{"v":1e-11,"d":"1.00E-11"},"COG2373","pfam07678","A2M_comp","A-macroglobulin complement component. This family includes the complement components region of the alpha-2-macroglobulin family.",".",".",".",".","."]
["ENSRNOG00000068990",6,0.385982629,0,0.03228093,11.9569861,3.579781881,0.020936565,0.010565047,"up","yes","Olr161","protein_coding","chr1:158941776-158944225:+","gi|47576505|ref|NP_001001000.1|",1549,0,"olfactory receptor Olr161 [Rattus norvegicus]","gi|90855788|gb|AC128039.4|",1253,0,"Rattus norvegicus BAC CH230-394A24 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q8NGI1",507,{"v":4E-176,"d":"4.00E-176"},"Putative olfactory receptor 56B2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.",".",".",".",".","."]
["ENSRNOG00000069096",6,0.385982629,0,0.03228093,11.9569861,3.579781881,0.020936565,0.010565047,"up","yes","ENSRNOG00000069096","lncRNA","chr17:44826628-44843909:+","gi|70938310|ref|XP_739846.1|",240,{"v":5e-19,"d":"5.00E-19"},"hypothetical protein, partial [Plasmodium chabaudi chabaudi]","gi|27261692|gb|AC126555.3|",500,0,"Mus musculus BAC clone RP23-474A17 from chromosome 13, complete sequence","P11369",95.1,{"v":1e-18,"d":"1.00E-18"},"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam07415","Herpes_LMP2","Gammaherpesvirus latent membrane protein (LMP2) protein. This family consists of several Gammaherpesvirus latent membrane protein (LMP2) proteins. Epstein-Barr virus is a human Gammaherpesvirus that infects and establishes latency in B lymphocytes in vivo. The latent membrane protein 2 (LMP2) gene is expressed in latently infected B cells and encodes two protein isoforms, LMP2A and LMP2B, that are identical except for an additional N-terminal 119 aa cytoplasmic domain which is present in the LMP2A isoform. LMP2A is thought to play a key role in either the establishment or the maintenance of latency and/or the reactivation of productive infection from the latent state. The significance of LMP2B and its role in pathogenesis remain unclear.",".",".",".",".","."]
["ENSRNOG00000069327",6,0.385982629,0,0.03228093,11.9569861,3.579781881,0.020936565,0.010565047,"up","yes","SNORD63","snoRNA","chr18:26541469-26541541:-",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","pfam04515","Choline_transpo","Plasma-membrane choline transporter. This family represents a high-affinity plasma-membrane choline transporter in C.elegans which is thought to be rate-limiting for ACh synthesis in cholinergic nerve terminals.",".",".",".",".","."]
["ENSRNOG00000070210",6,0.385982629,0,0.03228093,11.9569861,3.579781881,0.020936565,0.010565047,"up","yes","ENSRNOG00000070210","lncRNA","chr3:6116157-6148480:-","gi|149032848|gb|EDL87703.1|",172,{"v":8e-12,"d":"8.00E-12"},"putative RNA methylase MDS024, isoform CRA_b [Rattus norvegicus]","gi|62860465|gb|AC156832.2|",90,{"v":4e-37,"d":"4.00E-37"},"Mus musculus BAC clone RP24-212B22 from chromosome 9, complete sequence",".",".",".",".",".",".",".",".","pfam04747","DUF612","Protein of unknown function, DUF612. This family includes several uncharacterized proteins from Caenorhabditis elegans.",".",".",".",".","."]
["ENSRNOG00000070243",6,0.385982629,0,0.03228093,11.9569861,3.579781881,0.020936565,0.010565047,"up","yes","ENSRNOG00000070243","lncRNA","chr3:115425261-115447917:+","gi|148675219|gb|EDL07166.1|",129,2e-07,"mCG1028420, partial [Mus musculus]","gi|672017320|ref|XR_345179.2|",368,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102555576 (LOC102555576), transcript variant X1, ncRNA",".",".",".",".",".",".",".",".","pfam00852","Glyco_transf_10","Glycosyltransferase family 10 (fucosyltransferase). This family of Fucosyltransferases are the enzymes transferring fucose from GDP-Fucose to GlcNAc in an alpha1,3 linkage. This family is know as glycosyltransferase family 10.",".",".",".",".","."]
["ENSRNOG00000070466",6,0.385982629,0,0.03228093,11.9569861,3.579781881,0.020936565,0.010565047,"up","yes","ENSRNOG00000070466","pseudogene","chr9:15260659-15261424:+","gi|148691515|gb|EDL23462.1|",341,{"v":4e-39,"d":"4.00E-39"},"mCG147804 [Mus musculus]","gi|755559088|ref|XM_006524968.2|",222,{"v":3e-111,"d":"3.00E-111"},"PREDICTED: Mus musculus RIKEN cDNA 1600014C23 gene (1600014C23Rik), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam15242","FAM53","Family of FAM53. The FAM53 protein family refers to a family of proteins, which bind to a transcriptional regulator that modulates cell proliferation. It is known to be highly important in neural tube development. It is found in eukaryotes and is typically between 303 and 413 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000070710",6,0.385982629,0,0.03228093,11.9569861,3.579781881,0.020936565,0.010565047,"up","yes","ENSRNOG00000070710","lncRNA","chr9:105782280-105791235:-","gi|672024373|ref|XP_008756314.1|",181,{"v":2E-12,"d":"2.00E-12"},"PREDICTED: LOW QUALITY PROTEIN: spindlin-2B-like isoform X1 [Rattus norvegicus]","gi|672066281|ref|XM_008767409.1|",165,{"v":5E-79,"d":"5.00E-79"},"PREDICTED: Rattus norvegicus hypothetical LOC367333 (LOC367333), mRNA",".",".",".",".",".",".",".",".","pfam04749","PLAC8","PLAC8 family. This family includes the Placenta-specific gene 8 protein.",".",".",".",".","."]
["ENSRNOG00000071183",6,0.385982629,0,0.03228093,11.9569861,3.579781881,0.020936565,0.010565047,"up","yes","ENSRNOG00000071183","protein_coding","chrX:56619985-56621013:-","gi|672032358|ref|XP_001063822.2|",1508,0,"PREDICTED: melanoma-associated antigen B5-like [Rattus norvegicus]","gi|672032357|ref|XM_001063822.2|",1029,0,"PREDICTED: Rattus norvegicus similar to melanoma antigen 2 (RGD1563590), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam01454","MAGE","MAGE family. The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumors but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.",".",".",".",".","."]
["ENSRNOG00000059428",26,1.672591393,12,0.774742316,2.158900267,1.110296598,0.022188892,0.011152656,"up","yes","ENSRNOG00000059428","protein_coding","chr5:160314964-160317098:+","gi|2920825|gb|AAC04621.1|",886,{"v":2e-111,"d":"2.00E-111"},"ribosomal protein S2 [Rattus norvegicus]","gi|38014845|gb|BC060584.1|",891,0,"Rattus norvegicus hypothetical protein LOC100125366, mRNA (cDNA clone MGC:72931 IMAGE:6886957), complete cds","P46791",333,{"v":4E-109,"d":"4.00E-109"},"40S ribosomal protein S2 (Fragment)","SPCC576.08c",246,{"v":3e-75,"d":"3.00E-75"},"COG0098","pfam00333","Ribosomal_S5","Ribosomal protein S5, N-terminal domain.",".",".",".",".","."]
["ENSRNOG00000065546",26,1.672591393,12,0.774742316,2.158900267,1.110296598,0.022188892,0.011152656,"up","yes","ENSRNOG00000065546","protein_coding","chr3:153397580-153399505:-","gi|358439426|ref|NP_001240606.1|",293,{"v":4e-31,"d":"4.00E-31"},"protein WFDC11 precursor [Rattus norvegicus]","gi|358439425|ref|NM_001253677.1|",167,{"v":2e-80,"d":"2.00E-80"},"Rattus norvegicus WAP four-disulfide core domain 11 (Wfdc11), mRNA","A2A5H7",110,{"v":4e-30,"d":"4.00E-30"},"Protein WFDC11",".",".",".",".","pfam14745","WASH-7_N","WASH complex subunit 7, N-terminal. This family is the conserved N-terminal region of proteins that form subunit 7 of the WASH complex. In species such as Drosophila this protein is the only component of the 'complex'. This complex is a nucleation promoting factor necessary for the activation of Arp2/3 that nucleates and organizes actin filaments by associating with a pre-existing filament to induce the assembly of a branching filament. WASH thus effectively nucleates actin on endosomes.",".",".",".",".","."]
["ENSRNOG00000029107",23,1.479600078,10,0.645618597,2.291755668,1.196453242,0.022389272,0.011245455,"up","yes","AABR07015743.1","protein_coding","chr14:69045641-69046640:+","gi|8393536|ref|NP_058883.1|",851,{"v":5e-111,"d":"5.00E-111"},"high mobility group protein B2 [Rattus norvegicus]","gi|564376626|ref|XM_573272.5|",967,0,"PREDICTED: Rattus norvegicus high mobility group box 2-like 1 (Hmgb2l1), mRNA","P52925",332,{"v":2e-112,"d":"2.00E-112"},"High mobility group protein B2","SPAC57A10.09c",59.3,{"v":4e-10,"d":"4.00E-10"},"COG5648","pfam09011","HMG_box_2","HMG-box domain. This short 71 residue domain is an HMG-box domain. HMG-box domains mediate re-modelling of chromatin-structure. Mammalian HMG-box proteins are of two types: those that are non-sequence-specific DNA-binding proteins with two HMG-box domains and a long highly acidic C-tail; and a diverse group of sequence-specific transcription factor-proteins with either a single HMG-box or up to six copies, and no acidic C-tail.","GO:0002437|inflammatory response to antigenic stimulus;GO:0008150|biological_process;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0032496|response to lipopolysaccharide;GO:0045087|innate immune response;GO:0050767|regulation of neurogenesis;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:0072091|regulation of stem cell proliferation;","GO:0000785|chromatin;GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0000987|proximal promoter sequence-specific DNA binding;GO:0003674|molecular_function;","K11295","HMGB2; high mobility group protein B2"]
["ENSRNOG00000003790",15,0.964956573,5,0.322809298,2.989246524,1.579781881,0.022689204,0.011388089,"up","yes","Mael","protein_coding","chr13:78457073-78496657:-","gi|157819729|ref|NP_001102327.1|",2221,0,"protein maelstrom homolog [Rattus norvegicus]","gi|157819728|ref|NM_001108857.1|",1559,0,"Rattus norvegicus maelstrom spermatogenic transposon silencer (Mael), mRNA","Q8BVN9",846,0,"Protein maelstrom homolog",".",".",".",".","pfam13017","Maelstrom","piRNA pathway germ-plasm component. Maelstrom is a germ-plasm component protein, that is shown to be functionally involved in the piRNA pathway. It is conserved throughout Eukaryota, though it appears to have been lost from all examined teleost fish species. The domain architecture shows that it is coupled with several DNA- and RNA- related domains such as HMG box, SR-25-like and HDAC_interact domains. Sequence analysis and fold recognition have found a distant similarity between Maelstrom domain and the DnaQ 3'-5' exonuclease family with the RNase H fold (Exonuc_X-T, pfam00929); notably, that the Maelstrom domains from basal eukaryotes contain the conserved 3'-5' exonuclease active site residues (Asp-Glu-Asp-His-Asp, DEDHD). However, the animal and some amoeba maelstrom contain another set of conserved residues (Glu-His-His-Cys-His-Cys, EHHCHC). This evolutionary link together with structural examinations leads to the hypothesis that Maelstrom domains may have a potential nuclease-transposase activity or RNA-binding ability that may be implicated in piRNA biogenesis. A protein function evolution mode, namely \"active site switch\", has been proposed, in which the amoeba Maelstrom domains are the possible evolutionary intermediates due to their harbouring of the specific characteristics of both 3'-5' exonuclease and Maelstrom domains.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0000902|cell morphogenesis;GO:0006974|cellular response to DNA damage stimulus;GO:0007129|synapsis;GO:0007140|male meiotic nuclear division;GO:0007283|spermatogenesis;GO:0008630|intrinsic apoptotic signaling pathway in response to DNA damage;GO:0009566|fertilization;GO:0010629|negative regulation of gene expression;GO:0031047|gene silencing by RNA;GO:0034587|piRNA metabolic process;GO:0043046|DNA methylation involved in gamete generation;GO:0043066|negative regulation of apoptotic process;GO:0045892|negative regulation of transcription, DNA-templated;GO:0046620|regulation of organ growth;GO:0060964|regulation of gene silencing by miRNA;","GO:0000785|chromatin;GO:0001741|XY body;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0030849|autosome;GO:0033391|chromatoid body;GO:0043186|P granule;GO:0048471|perinuclear region of cytoplasm;GO:0071547|piP-body;","GO:0043565|sequence-specific DNA binding;","K18411","MAEL; protein maelstrom"]
["ENSRNOG00000031951",15,0.964956573,5,0.322809298,2.989246524,1.579781881,0.022689204,0.011388089,"up","yes","ENSRNOG00000031951","protein_coding","chr3:44581068-44630051:+","gi|295391840|ref|NP_001171287.1|",3053,0,"uncharacterized protein LOC100361645 [Rattus norvegicus]","gi|295391839|ref|NM_001177816.1|",1755,0,"Rattus norvegicus LRRGT00075-like (LOC100361645), mRNA","P11369",185,{"v":6e-48,"d":"6.00E-48"},"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam12488","DUF3704","Protein of unknown function (DUF3704). This domain family is found in eukaryotes, and is approximately 30 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000049045",15,0.964956573,5,0.322809298,2.989246524,1.579781881,0.022689204,0.011388089,"up","yes","AABR07045032.1","protein_coding","chr20:30335628-30373867:-","gi|21703836|ref|NP_663394.1|",4727,0,"putative hexokinase HKDC1 [Mus musculus]","gi|21703835|ref|NM_145419.1|",2535,0,"Mus musculus hexokinase domain containing 1 (Hkdc1), mRNA","Q91W97",1825,0,"Putative hexokinase HKDC1","SPAC24H6.04",282,{"v":5e-83,"d":"5.00E-83"},"COG5026","pfam03727","Hexokinase_2","Hexokinase. Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam00349. Some members of the family have two copies of each of these domains.",".",".",".",".","."]
["ENSRNOG00000057108",15,0.964956573,5,0.322809298,2.989246524,1.579781881,0.022689204,0.011388089,"up","yes","AABR07066109.1","snoRNA","chr9:4281481-4281609:-",".",".",".",".","gi|672060403|ref|XR_593658.1|",129,{"v":6e-60,"d":"6.00E-60"},"PREDICTED: Rattus norvegicus uncharacterized LOC102549144 (LOC102549144), transcript variant X4, ncRNA",".",".",".",".",".",".",".",".","pfam05940","NnrS","NnrS protein. This family consists of several bacterial NnrS like proteins. NnrS is a putative heme-Cu protein (NnrS) and a member of the short-chain dehydrogenase family. Expression of nnrS is dependent on the transcriptional regulator NnrR, which also regulates expression of genes required for the reduction of nitrite to nitrous oxide, including nirK and nor. NnrS is a haem- and copper-containing membrane protein. Genes encoding putative orthologues of NnrS are sometimes but not always found in bacteria encoding nitrite and/or nitric oxide reductase.",".",".",".",".","."]
["ENSRNOG00000004443",7,0.450313067,1,0.06456186,6.974908556,2.802174303,0.025483974,0.012652948,"up","yes","Sptlc3","protein_coding","chr3:126847878-126978010:+","gi|157817891|ref|NP_001099987.1|",2923,0,"serine palmitoyltransferase 3 [Rattus norvegicus]","gi|157817890|ref|NM_001106517.1|",2837,0,"Rattus norvegicus serine palmitoyltransferase, long chain base subunit 3 (Sptlc3), mRNA","Q8BG54",991,0,"Serine palmitoyltransferase 3","YDR062w",399,{"v":4e-126,"d":"4.00E-126"},"COG0156","pfam00155","Aminotran_1_2","Aminotransferase class I and II.","GO:0008150|biological_process;GO:0046512|sphingosine biosynthetic process;GO:0046513|ceramide biosynthetic process;GO:0046520|sphingoid biosynthetic process;","GO:0005575|cellular_component;GO:0016021|integral component of membrane;GO:0017059|serine C-palmitoyltransferase complex;","GO:0003674|molecular_function;GO:0004758|serine C-palmitoyltransferase activity;GO:0008483|transaminase activity;GO:0030170|pyridoxal phosphate binding;","K00654","SPT; serine palmitoyltransferase [EC:2.3.1.50]"]
["ENSRNOG00000005652",7,0.450313067,1,0.06456186,6.974908556,2.802174303,0.025483974,0.012652948,"up","yes","Cntn4","protein_coding","chr4:139099152-139621090:+","gi|16758746|ref|NP_446331.1|",5410,0,"contactin-4 precursor [Rattus norvegicus]","gi|16758745|ref|NM_053879.1|",4244,0,"Rattus norvegicus contactin 4 (Cntn4), mRNA","Q62845",2088,0,"Contactin-4",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0007155|cell adhesion;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007399|nervous system development;GO:0007411|axon guidance;GO:0007420|brain development;GO:0031175|neuron projection development;GO:0045665|negative regulation of neuron differentiation;GO:0070593|dendrite self-avoidance;","GO:0005576|extracellular region;GO:0005886|plasma membrane;GO:0030424|axon;GO:0031225|anchored component of membrane;","GO:0098632|cell-cell adhesion mediator activity;","K06762","CNTN4; contactin 4"]
["ENSRNOG00000011671",7,0.450313067,1,0.06456186,6.974908556,2.802174303,0.025483974,0.012652948,"up","yes","ENSRNOG00000011671","protein_coding","chr19:28669059-28704508:+","gi|71043912|ref|NP_001020935.1|",833,{"v":9e-106,"d":"9.00E-106"},"uncharacterized protein C4orf51 homolog [Rattus norvegicus]","gi|71043911|ref|NM_001025764.1|",1519,0,"Rattus norvegicus LOC498933 (LOC498933), mRNA",".",".",".",".",".",".",".",".","pfam03363","Herpes_LP","Herpesvirus leader protein.",".",".",".",".","."]
["ENSRNOG00000015448",7,0.450313067,1,0.06456186,6.974908556,2.802174303,0.025483974,0.012652948,"up","yes","Dipk1c","protein_coding","chr18:78087991-78109904:+","gi|62664711|ref|XP_574179.1|",1825,0,"PREDICTED: protein FAM69C [Rattus norvegicus]","gi|672030959|ref|XM_001061354.5|",2045,0,"PREDICTED: Rattus norvegicus family with sequence similarity 69, member C (Fam69c), mRNA","Q8BQT2",671,0,"Protein FAM69C",".",".",".",".","pfam12260","PIP49_C","Protein-kinase domain of FAM69. This is the C-terminal region of a family of FAM69 proteins from Metazoa and Viridiplantae that are active protein-kinases. The family members have a short transmembrane helix close to the N-terminus, and thereafter are highly enriched with cysteines. FAM69 proteins are localized to the endoplasmic reticulum. Many members also have a short EF-hand, calcium-binding, domain just upstream of the kinase domain. The exact function of the more N-terminal family is uncertain.",".","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000020492",7,0.450313067,1,0.06456186,6.974908556,2.802174303,0.025483974,0.012652948,"up","yes","Rps27a-ps28","protein_coding","chr18:24242880-24243492:-","gi|13195690|ref|NP_077239.1|",608,{"v":6e-78,"d":"6.00E-78"},"ubiquitin-40S ribosomal protein S27a precursor [Mus musculus]","gi|796616106|ref|NG_042075.1|",372,0,"Rattus norvegicus ribosomal protein S27a, pseudogene 1 (Rps27a-ps1) on chromosome 5","P62982",238,{"v":2E-79,"d":"2.00E-79"},"Ubiquitin-40S ribosomal protein S27a","ECU02g0740i",139,{"v":7e-42,"d":"7.00E-42"},"COG5272","pfam00240","ubiquitin","Ubiquitin family. This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) Nedd8, Elongin B, Rub1, and Parkin. A number of them are thought to carry a distinctive five-residue motif termed the proteasome-interacting motif (PIM), which may have a biologically significant role in protein delivery to proteasomes and recruitment of proteasomes to transcription sites.","GO:0006412|translation;",".","GO:0046872|metal ion binding;",".","."]
["ENSRNOG00000021020",7,0.450313067,1,0.06456186,6.974908556,2.802174303,0.025483974,0.012652948,"up","yes","Gpha2","protein_coding","chr1:203526122-203527270:+","gi|19424340|ref|NP_598303.1|",685,{"v":3e-88,"d":"3.00E-88"},"glycoprotein hormone alpha-2 precursor [Rattus norvegicus]","gi|24475801|ref|NM_133619.2|",766,0,"Rattus norvegicus glycoprotein hormone alpha 2 (Gpha2), mRNA","Q925Q4",268,{"v":1E-89,"d":"1.00E-89"},"Glycoprotein hormone alpha-2",".",".",".",".","pfam00236","Hormone_6","Glycoprotein hormone.","GO:0007166|cell surface receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;","GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0005179|hormone activity;GO:0031531|thyrotropin-releasing hormone receptor binding;GO:0046982|protein heterodimerization activity;GO:0051427|hormone receptor binding;","K25483","GPHA2; glycoprotein hormone alpha-2"]
["ENSRNOG00000025300",7,0.450313067,1,0.06456186,6.974908556,2.802174303,0.025483974,0.012652948,"up","yes","Fer1l6","protein_coding","chr7:90061924-90215214:+","gi|672021879|ref|XP_008774693.1|",9242,0,"PREDICTED: fer-1-like protein 6 isoform X1 [Rattus norvegicus]","gi|672021878|ref|XM_008776471.1|",6019,0,"PREDICTED: Rattus norvegicus fer-1-like family member 6 (Fer1l6), transcript variant X1, mRNA","Q2WGJ9",3140,0,"Fer-1-like protein 6",".",".",".",".","pfam08151","FerI","FerI (NUC094) domain. This domain is present in proteins of the Ferlin family. It is often located between two C2 domains.","GO:0007009|plasma membrane organization;GO:0009617|response to bacterium;","GO:0016021|integral component of membrane;","GO:0046872|metal ion binding;","K22127","FER1L6; fer-1-like protein 6"]
["ENSRNOG00000034258",7,0.450313067,1,0.06456186,6.974908556,2.802174303,0.025483974,0.012652948,"up","yes","Xirp2","protein_coding","chr3:51870092-52213091:+","gi|42538984|ref|NP_973718.1|",16449,0,"xin actin-binding repeat-containing protein 2 [Rattus norvegicus]","gi|42538983|ref|NM_201989.1|",12011,0,"Rattus norvegicus xin actin-binding repeat containing 2 (Xirp2), mRNA","Q71LX6",6336,0,"Xin actin-binding repeat-containing protein 2",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.","GO:0003281|ventricular septum development;GO:0007015|actin filament organization;GO:0007507|heart development;GO:0030036|actin cytoskeleton organization;GO:0045216|cell-cell junction organization;GO:0055008|cardiac muscle tissue morphogenesis;","GO:0001725|stress fiber;GO:0005925|focal adhesion;GO:0030018|Z disc;","GO:0051015|actin filament binding;GO:0051393|alpha-actinin binding;",".","."]
["ENSRNOG00000046864",7,0.450313067,1,0.06456186,6.974908556,2.802174303,0.025483974,0.012652948,"up","yes","Acot4","protein_coding","chr6:103668753-103673917:+","gi|157822089|ref|NP_001102910.1|",2072,0,"acyl-coenzyme A thioesterase 4 [Rattus norvegicus]","gi|157822088|ref|NM_001109440.1|",2434,0,"Rattus norvegicus acyl-CoA thioesterase 4 (Acot4), mRNA","Q8BWN8",744,0,"Acyl-coenzyme A thioesterase 4","CAC3407",135,{"v":5e-33,"d":"5.00E-33"},"COG1073","pfam08840","BAAT_C","BAAT / Acyl-CoA thioester hydrolase C terminal. This catalytic domain is found at the C terminal of acyl-CoA thioester hydrolases and bile acid-CoA:amino acid N-acetyltransferases (BAAT).","GO:0000038|very long-chain fatty acid metabolic process;GO:0001676|long-chain fatty acid metabolic process;GO:0006104|succinyl-CoA metabolic process;GO:0006631|fatty acid metabolic process;GO:0006637|acyl-CoA metabolic process;GO:0032788|saturated monocarboxylic acid metabolic process;GO:0032789|unsaturated monocarboxylic acid metabolic process;GO:0043648|dicarboxylic acid metabolic process;GO:0043649|dicarboxylic acid catabolic process;GO:0046459|short-chain fatty acid metabolic process;","GO:0005777|peroxisome;","GO:0004778|succinyl-CoA hydrolase activity;GO:0047617|acyl-CoA hydrolase activity;","K01068","ACOT1_2_4; acyl-coenzyme A thioesterase 1/2/4 [EC:3.1.2.2]"]
["ENSRNOG00000061131",7,0.450313067,1,0.06456186,6.974908556,2.802174303,0.025483974,0.012652948,"up","yes","U6","snRNA","chr13:92897631-92897736:+",".",".",".",".","gi|354799747|gb|JN964248.1|",75,{"v":4e-30,"d":"4.00E-30"},"Mus musculus targeted non-conditional, lacZ-tagged mutant allele E130309F12Rik:tm1e(EUCOMM)Hmgu; transgenic",".",".",".",".",".",".",".",".","pfam00757","Furin-like","Furin-like cysteine rich region.",".",".",".",".","."]
["ENSRNOG00000063027",7,0.450313067,1,0.06456186,6.974908556,2.802174303,0.025483974,0.012652948,"up","yes","ENSRNOG00000063027","pseudogene","chr2:173029694-173031251:+","gi|589935503|ref|XP_006980523.1|",1658,0,"PREDICTED: heterogeneous nuclear ribonucleoprotein F-like [Peromyscus maniculatus bairdii]","gi|672055185|ref|XR_354487.2|",586,0,"PREDICTED: Rattus norvegicus similar to heterogeneous nuclear ribonucleoprotein F (LOC679604), transcript variant X2, misc_RNA","Q794E4",643,0,"Heterogeneous nuclear ribonucleoprotein F",".",".",".",".","pfam08080","zf-RNPHF","RNPHF zinc finger. This domain is a putative zinc-binding domain (CHHC motif) in RNP H and F. The domain is often associated with pfam00076.",".",".",".",".","."]
["ENSRNOG00000063029",7,0.450313067,1,0.06456186,6.974908556,2.802174303,0.025483974,0.012652948,"up","yes","ENSRNOG00000063029","lncRNA","chr1:193753396-193759800:+",".",".",".",".","gi|672038915|ref|XM_008760004.1|",581,0,"PREDICTED: Rattus norvegicus janus kinase and microtubule interacting protein 3 (Jakmip3), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam07142","DUF1388","Repeat of unknown function (DUF1388). This family consists of several repeats of around 29 residues in length. Members of this family are found in the variable surface lipoproteins in Mycoplasma bovis and in mammalian neurofilament triplet H (NefH or NF-H) proteins. This repeat contains several Lys-Ser-Pro (KSP) motifs and in NefH these are thought to function as the main target for neurofilament directed protein kinases in vivo.",".",".",".",".","."]
["ENSRNOG00000063174",7,0.450313067,1,0.06456186,6.974908556,2.802174303,0.025483974,0.012652948,"up","yes","ENSRNOG00000063174","protein_coding","chr17:54800564-54803205:-","gi|564391905|ref|XP_006254195.1|",1436,0,"PREDICTED: ral guanine nucleotide dissociation stimulator-like isoform X1 [Rattus norvegicus]","gi|672082245|ref|XM_006254133.2|",1250,0,"PREDICTED: Rattus norvegicus similar to Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS) (LOC686142), transcript variant X1, mRNA","Q03386",93.2,{"v":6e-19,"d":"6.00E-19"},"Ral guanine nucleotide dissociation stimulator",".",".",".",".","pfam00618","RasGEF_N","RasGEF N-terminal motif. A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this motif/domain N-terminal to the RasGef (Cdc25-like) domain.",".",".",".",".","."]
["ENSRNOG00000063537",7,0.450313067,1,0.06456186,6.974908556,2.802174303,0.025483974,0.012652948,"up","yes","ENSRNOG00000063537","lncRNA","chr4:90149070-90154178:-","gi|149037052|gb|EDL91613.1|",230,{"v":9e-20,"d":"9.00E-20"},"rCG55335 [Rattus norvegicus]","gi|672018386|ref|XR_345863.2|",1520,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102556581 (LOC102556581), transcript variant X1, ncRNA",".",".",".",".",".",".",".",".","pfam15498","Dendrin","Nephrin and CD2AP-binding protein, Dendrin. Dendrin is a family of eukaryotic proteins found in the podocytes of the kidneys. Dendrin, originally identified in telencephalic dendrites, is a constituent of the slit diaphragm, SD, complex of podocytes, where it directly binds to nephrin and CD2AP. Kidney podocytes and their slit diaphragms (SDs) form the final barrier to urinary protein loss. SD proteins also participate in intracellular signalling pathways. Dendrin appears to prevent programmed cell death (apoptosis) through its binding to nephrin. The SD protein nephrin serves as a component of a signalling complex that directly links podocyte junctional integrity to actin cytoskeletal dynamics. Thus, dendrin is identified as an SD family with proapoptotic signalling properties that accumulates in the podocyte nucleus in response to glomerular injury.",".",".",".",".","."]
["ENSRNOG00000064063",7,0.450313067,1,0.06456186,6.974908556,2.802174303,0.025483974,0.012652948,"up","yes","ENSRNOG00000064063","protein_coding","chr9:23672586-23674431:-","gi|564346357|ref|XP_006236363.1|",1782,0,"PREDICTED: E3 ubiquitin-protein ligase makorin-1 isoform X1 [Rattus norvegicus]","gi|672049122|ref|XM_006236304.2|",861,0,"PREDICTED: Rattus norvegicus makorin ring finger protein 1 (Mkrn1), transcript variant X4, mRNA","Q9QXP6",672,0,"E3 ubiquitin-protein ligase makorin-1",".",".",".",".","pfam12678","zf-rbx1","RING-H2 zinc finger. There are 8 cysteine/ histidine residues which are proposed to be the conserved residues involved in zinc binding. The protein, of which this domain is the conserved region, participates in diverse functions relevant to chromosome metabolizm and cell cycle control.",".",".",".",".","."]
["ENSRNOG00000065544",7,0.450313067,1,0.06456186,6.974908556,2.802174303,0.025483974,0.012652948,"up","yes","Olr1341","protein_coding","chr8:40533033-40541586:+","gi|47576203|ref|NP_001000482.1|",1502,0,"olfactory receptor Olr1341 [Rattus norvegicus]","gi|51870916|gb|AC136021.5|",1602,0,"Mus musculus BAC clone RP24-473P10 from 9, complete sequence","Q8NH79",498,{"v":3e-164,"d":"3.00E-164"},"Olfactory receptor 6X1",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.",".",".",".",".","."]
["ENSRNOG00000065948",7,0.450313067,1,0.06456186,6.974908556,2.802174303,0.025483974,0.012652948,"up","yes","ENSRNOG00000065948","lncRNA","chr20:17904326-17921740:-",".",".",".",".","gi|38198748|gb|AC122896.4|",132,{"v":1e-60,"d":"1.00E-60"},"Mus musculus BAC clone RP23-69N8 from chromosome 10, complete sequence",".",".",".",".",".",".",".",".","pfam00554","RHD","Rel homology domain (RHD). Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See pfam01833) that binds to DNA.",".",".",".",".","."]
["ENSRNOG00000067792",7,0.450313067,1,0.06456186,6.974908556,2.802174303,0.025483974,0.012652948,"up","yes","ENSRNOG00000067792","protein_coding","chr1:238567690-238602876:-","gi|26337919|dbj|BAC32645.1|",558,{"v":4e-62,"d":"4.00E-62"},"unnamed protein product [Mus musculus]","gi|260441710|gb|AC120070.6|",2690,0,"Rattus norvegicus BAC CH230-481C18 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q64458",103,{"v":2e-21,"d":"2.00E-21"},"Cytochrome P450 2C29",".",".",".",".","pfam02337","Gag_p10","Retroviral GAG p10 protein. This family consists of various retroviral GAG (core) polyproteins and encompasses the p10 region producing the p10 protein upon proteolytic cleavage of GAG by retroviral protease. The p10 or matrix protein (MA) is associated with the virus envelope glycoproteins in most mammalian retroviruses and may be involved in virus particle assembly, transport and budding. Some of the GAG polyproteins have alternate cleavage sites leading to the production of alternative and longer cleavage products (e.g. p19) the alignment of this family only covers the approximately N-terminal (GAG) 100 amino acid region of homology to p10.",".",".",".",".","."]
["ENSRNOG00000069867",7,0.450313067,1,0.06456186,6.974908556,2.802174303,0.025483974,0.012652948,"up","yes","ENSRNOG00000069867","protein_coding","chr3:118062938-118064209:+","gi|393393852|ref|NP_001257315.1|",512,{"v":2e-64,"d":"2.00E-64"},"uncharacterized protein LOC688925 [Rattus norvegicus]","gi|393393851|ref|NM_001270386.1|",269,{"v":3e-137,"d":"3.00E-137"},"Rattus norvegicus similar to Glutathione S-transferase alpha-4 (LOC688925), mRNA","P14942",138,{"v":5e-40,"d":"5.00E-40"},"Glutathione S-transferase alpha-4",".",".",".",".","pfam02798","GST_N","Glutathione S-transferase, N-terminal domain. Function: conjugation of reduced glutathione to a variety of targets. Also included in the alignment, but are not GSTs: * S-crystallins from squid. Similarity to GST previously noted. * Eukaryotic elongation factors 1-gamma. Not known to have GST activity; similarity not previously recognized. * HSP26 family of stress-related proteins. including auxin-regulated proteins in plants and stringent starvation proteins in Escherichia coli. Not known to have GST activity. Similarity not previously recognized. The glutathione molecule binds in a cleft between N and C-terminal domains - the catalytically important residues are proposed to reside in the N-terminal domain.",".",".",".",".","."]
["ENSRNOG00000070087",7,0.450313067,1,0.06456186,6.974908556,2.802174303,0.025483974,0.012652948,"up","yes","ENSRNOG00000070087","lncRNA","chr3:118480706-118483267:-",".",".",".",".","gi|22759520|emb|AL808128.4|",226,{"v":2e-112,"d":"2.00E-112"},"Mouse DNA sequence from clone RP23-387C21 on chromosome 2, complete sequence",".",".",".",".",".",".",".",".","pfam08395","7tm_7","7tm Chemosensory receptor. This family includes a number of gustatory and odorant receptors mainly from insect species such as A. gambiae and D. melanogaster. They are classified as G-protein-coupled receptors (GPCRs), or seven-transmembrane receptors. They show high sequence divergence, consistent with an ancient origin for the family.",".",".",".",".","."]
["ENSRNOG00000008988",13,0.836295696,4,0.258247439,3.238350401,1.695259099,0.02566471,0.012730511,"up","yes","Cyp2d2","protein_coding","chr7:113935138-113939209:-","gi|117242|sp|P10634.2|CP2DQ_RAT",2503,0,"RecName: Full=Cytochrome P450 2D26; AltName: Full=CYPIID26; AltName: Full=Cytochrome P450-CMF2; AltName: Full=Cytochrome P450-DB2; AltName: Full=Debrisoquine 4-hydroxylase","gi|6978746|ref|NM_012730.1|",1668,0,"Rattus norvegicus cytochrome P450, family 2, subfamily d, polypeptide 2 (Cyp2d2), mRNA","P10634",973,0,"Cytochrome P450 2D26","alr1450",81.3,{"v":2e-15,"d":"2.00E-15"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0006082|organic acid metabolic process;GO:0006805|xenobiotic metabolic process;GO:0007565|female pregnancy;GO:0009410|response to xenobiotic stimulus;GO:0019369|arachidonic acid metabolic process;GO:0042178|xenobiotic catabolic process;","GO:0005737|cytoplasm;GO:0005789|endoplasmic reticulum membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0004497|monooxygenase activity;GO:0005506|iron ion binding;GO:0008395|steroid hydroxylase activity;GO:0016712|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0020037|heme binding;GO:0070330|aromatase activity;","K07414","CYP2D; cytochrome P450 family 2 subfamily D [EC:1.14.14.1]"]
["ENSRNOG00000019058",13,0.836295696,4,0.258247439,3.238350401,1.695259099,0.02566471,0.012730511,"up","yes","Gstm3l","protein_coding","chr2:195607289-195612475:-","gi|149025659|gb|EDL81902.1|",1174,{"v":2E-159,"d":"2.00E-159"},"rCG28672, isoform CRA_a [Rattus norvegicus]","gi|324711004|ref|NM_010359.2|",692,0,"Mus musculus glutathione S-transferase, mu 3 (Gstm3), mRNA","P19639",435,{"v":1e-152,"d":"1.00E-152"},"Glutathione S-transferase Mu 3",".",".",".",".","pfam00043","GST_C","Glutathione S-transferase, C-terminal domain. GST conjugates reduced glutathione to a variety of targets including S-crystallin from squid, the eukaryotic elongation factor 1-gamma, the HSP26 family of stress-related proteins and auxin-regulated proteins in plants. Stringent starvation proteins in Escherichia coli are also included in the alignment but are not known to have GST activity.     The glutathione molecule binds in a cleft between N and C-terminal domains. The catalytically important residues are proposed to reside in the N-terminal domain. In plants, GSTs are encoded by a large gene family (48 GST genes in Arabidopsis) and can be divided into the phi, tau, theta, zeta, and lambda classes.","GO:0006749|glutathione metabolic process;","GO:0005829|cytosol;GO:0045171|intercellular bridge;","GO:0004364|glutathione transferase activity;GO:0042802|identical protein binding;","K00799","GST, gst; glutathione S-transferase [EC:2.5.1.18]"]
["ENSRNOG00000066189",13,0.836295696,4,0.258247439,3.238350401,1.695259099,0.02566471,0.012730511,"up","yes","ENSRNOG00000066189","lncRNA","chr7:95726722-95741941:-","gi|148671381|gb|EDL03328.1|",151,3e-08,"mCG1026209, isoform CRA_a [Mus musculus]","gi|84875700|gb|AC174724.3|",760,0,"Mus musculus BAC clone RP23-101A6 from chromosome 15, complete sequence",".",".",".",".",".",".",".",".","pfam15441","ARHGEF5_35","Rho guanine nucleotide exchange factor 5/35. This family includes Rho guanine nucleotide exchange factor 5 and Rho guanine nucleotide exchange factor 35.",".",".",".",".","."]
["ENSRNOG00000067969",13,0.836295696,4,0.258247439,3.238350401,1.695259099,0.02566471,0.012730511,"up","yes","ENSRNOG00000067969","lncRNA","chr8:109263313-109264986:+",".",".",".",".","gi|568963087|ref|XM_006511792.1|",1032,0,"PREDICTED: Mus musculus DALR anticodon binding domain containing 3 (Dalrd3), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam13340","DUF4096","Putative transposase of IS4/5 family (DUF4096).",".",".",".",".","."]
["ENSRNOG00000001379",18,1.157947887,7,0.451933018,2.562211306,1.35738946,0.025814584,0.012797073,"up","yes","Cyp3a62","protein_coding","chr12:16397998-16433833:+","gi|149035099|gb|EDL89819.1|",2376,0,"rCG42677 [Rattus norvegicus]","gi|66730478|ref|NM_001024232.1|",1775,0,"Rattus norvegicus cytochrome P450, family 3, subfamily a, polypeptide 62 (Cyp3a62), mRNA","P51538",778,0,"Cytochrome P450 3A9","BH0579",114,{"v":2e-26,"d":"2.00E-26"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0008202|steroid metabolic process;GO:0036378|calcitriol biosynthetic process from calciol;GO:0070989|oxidative demethylation;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0008395|steroid hydroxylase activity;GO:0020037|heme binding;GO:0050649|testosterone 6-beta-hydroxylase activity;GO:0070330|aromatase activity;","K07424","CYP3A; cytochrome P450 family 3 subfamily A [EC:1.14.14.1]"]
["ENSRNOG00000019704",18,1.157947887,7,0.451933018,2.562211306,1.35738946,0.025814584,0.012797073,"up","yes","Resp18","protein_coding","chr9:76764590-76778722:-","gi|9507041|ref|NP_062151.1|",751,{"v":4E-92,"d":"4.00E-92"},"regulated endocrine-specific protein 18 precursor [Rattus norvegicus]","gi|113205094|gb|AC121001.5|",1599,0,"Rattus norvegicus BAC CH230-189D6 () complete sequence","P47940",293,{"v":1e-93,"d":"1.00E-93"},"Regulated endocrine-specific protein 18",".",".",".",".","pfam14948","RESP18","RESP18 domain. This domain is found in the glucocorticoid-responsive protein regulated endocrine-specific protein 18 (RESP18) and in the N-terminal extracellular region of receptor-type tyrosine-protein phosphatases containing the protein-tyrosine phosphatase receptor IA-2 domain (pfam11548).","GO:0001701|in utero embryonic development;GO:0008150|biological_process;","GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0030141|secretory granule;GO:0043204|perikaryon;GO:0048237|rough endoplasmic reticulum lumen;","GO:0003674|molecular_function;",".","."]
["ENSRNOG00000019914",18,1.157947887,7,0.451933018,2.562211306,1.35738946,0.025814584,0.012797073,"up","yes","Tlcd3b","protein_coding","chr1:181422830-181439743:+","gi|564330937|ref|XP_006230299.1|",1391,0,"PREDICTED: protein FAM57B isoform X1 [Rattus norvegicus]","gi|672038419|ref|XM_006230237.2|",1671,0,"PREDICTED: Rattus norvegicus family with sequence similarity 57, member B (Fam57b), transcript variant X1, mRNA","Q7TNV1",453,{"v":5e-155,"d":"5.00E-155"},"Protein FAM57B",".",".",".",".","pfam03798","TRAM_LAG1_CLN8","TLC domain.","GO:0045599|negative regulation of fat cell differentiation;GO:0046513|ceramide biosynthetic process;GO:0055088|lipid homeostasis;","GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;","GO:0050291|sphingosine N-acyltransferase activity;",".","."]
["ENSRNOG00000069302",18,1.157947887,7,0.451933018,2.562211306,1.35738946,0.025814584,0.012797073,"up","yes","ENSRNOG00000069302","lncRNA","chr9:1046547-1049874:+",".",".",".",".","gi|672064133|ref|XR_594271.1|",1628,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103693194 (LOC103693194), ncRNA",".",".",".",".",".",".",".",".","pfam06444","NADH_dehy_S2_C","NADH dehydrogenase subunit 2 C-terminus. This family consists of the C-terminal region specific to the eukaryotic NADH dehydrogenase subunit 2 protein and is found in conjunction with pfam00361.",".",".",".",".","."]
["ENSRNOG00000060587",27,1.736921831,13,0.839304176,2.069478363,1.049267165,0.026014601,0.012888397,"up","yes","AABR07002627.1","protein_coding","chr1:76911602-76914024:-","gi|676263391|gb|KFO20116.1|",964,{"v":1e-120,"d":"1.00E-120"},"Transmembrane protein 64 [Fukomys damarensis]","gi|672013612|ref|XR_598820.1|",2409,0,"PREDICTED: Rattus norvegicus hypothetical protein LOC686461 (LOC686461), misc_RNA","Q6YI46",365,{"v":8e-117,"d":"8.00E-117"},"Transmembrane protein 64","slr0305",65.9,{"v":3E-11,"d":"3.00E-11"},"COG0398","pfam09335","SNARE_assoc","SNARE associated Golgi protein. This is a family of SNARE associated Golgi proteins. The yeast member of this family localizes with the t-SNARE Tlg2.",".",".",".",".","."]
["ENSRNOG00000067637",27,1.736921831,13,0.839304176,2.069478363,1.049267165,0.026014601,0.012888397,"up","yes","ENSRNOG00000067637","lncRNA","chr1:183318398-183320897:-",".",".",".",".","gi|354794353|gb|JN958854.1|",133,{"v":4e-61,"d":"4.00E-61"},"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Sec23ip:tm1e(EUCOMM)Hmgu; transgenic",".",".",".",".",".",".",".",".","pfam11996","DUF3491","Protein of unknown function (DUF3491). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 286 to 3225 amino acids in length. This protein is found associated with pfam04488. This protein is found associated with pfam04488.",".",".",".",".","."]
["ENSRNOG00000068246",27,1.736921831,13,0.839304176,2.069478363,1.049267165,0.026014601,0.012888397,"up","yes","ENSRNOG00000068246","lncRNA","chr3:18372888-18387230:+","gi|149054000|gb|EDM05817.1|",172,{"v":1e-12,"d":"1.00E-12"},"rCG33163 [Rattus norvegicus]","gi|672016645|ref|XR_600126.1|",515,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103691771 (LOC103691771), ncRNA",".",".",".",".",".",".",".",".","pfam02093","Gag_p30","Gag P30 core shell protein. According to Swiss-Prot annotation this protein is the viral core shell protein. P30 is essential for viral assembly.",".",".",".",".","."]
["ENSRNOG00000070140",24,1.543930516,11,0.710180456,2.173997472,1.120350263,0.026867996,0.01328699,"up","yes","ENSRNOG00000070140","lncRNA","chr8:110508213-110510706:+",".",".",".",".","gi|672063476|ref|XR_594141.1|",1348,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102550415 (LOC102550415), transcript variant X1, ncRNA",".",".",".",".",".",".",".",".","pfam14724","mit_SMPDase","Mitochondrial-associated sphingomyelin phosphodiesterase. The GO annotation for this family indicates that it is a single-pass membrane protein, and it appears to be found in mitochondrial membranes. Sphingolipids play important roles in regulating cellular responses, and although mitochondria contain sphingolipids, direct regulation of their levels in mitochondria or mitochondria-associated membranes is mostly unclear. Sphingomyelin phosphodiesterases catalyse the hydrolysis of sphingomyelin to ceramide and phosphocholine, and these metabolites are involved in signalling pathways.",".",".",".",".","."]
["ENSRNOG00000064283",21,1.350939202,9,0.581056737,2.324969519,1.217211802,0.02696403,0.013327557,"up","yes","ENSRNOG00000064283","pseudogene","chr7:99446712-99447959:-","gi|672021948|ref|XP_008774698.1|",2068,0,"PREDICTED: LOW QUALITY PROTEIN: putative ribosomal RNA methyltransferase NOP2 [Rattus norvegicus]","gi|672021947|ref|XM_008776476.1|",710,0,"PREDICTED: Rattus norvegicus similar to nucleolar protein 1 (LOC500881), mRNA","Q922K7",631,0,"Probable 28S rRNA (cytosine-C(5))-methyltransferase","SPBP8B7.20c",300,{"v":3e-94,"d":"3.00E-94"},"COG0144","pfam01189","Nol1_Nop2_Fmu","NOL1/NOP2/sun family.",".",".",".",".","."]
["ENSRNOG00000026446",11,0.70763482,3,0.193685579,3.653523529,1.869288499,0.02809796,0.013837671,"up","yes","Wee2","protein_coding","chr4:69239299-69261093:+","gi|109473386|ref|XP_001070431.1|",3009,0,"PREDICTED: wee1-like protein kinase 2 isoform X1 [Rattus norvegicus]","gi|672018189|ref|XM_001070431.5|",1674,0,"PREDICTED: Rattus norvegicus WEE1 homolog 2 (S. pombe) (Wee2), transcript variant X1, mRNA","Q66JT0",1004,0,"Wee1-like protein kinase 2",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0000278|mitotic cell cycle;GO:0007143|female meiotic nuclear division;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0035038|female pronucleus assembly;GO:0042327|positive regulation of phosphorylation;GO:0045736|negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0060631|regulation of meiosis I;GO:0080154|regulation of fertilization;GO:1900194|negative regulation of oocyte maturation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0000287|magnesium ion binding;GO:0004672|protein kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0005524|ATP binding;","K06632","WEE1; wee1-like protein kinase [EC:2.7.11.1]"]
["ENSRNOG00000036882",11,0.70763482,3,0.193685579,3.653523529,1.869288499,0.02809796,0.013837671,"up","yes","Fbxo47","protein_coding","chr10:82849730-82879538:-","gi|672069264|ref|XP_008766423.1|",2385,0,"PREDICTED: LOW QUALITY PROTEIN: F-box only protein 47 isoform X2 [Rattus norvegicus]","gi|672069263|ref|XM_008768201.1|",1457,0,"PREDICTED: Rattus norvegicus F-box protein 47 (Fbxo47), transcript variant X2, mRNA","A2A6H3",883,0,"F-box only protein 47",".",".",".",".","pfam00646","F-box","F-box domain. This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.",".",".",".","K10321","FBXO47; F-box protein 47"]
["ENSRNOG00000051590",11,0.70763482,3,0.193685579,3.653523529,1.869288499,0.02809796,0.013837671,"up","yes","ENSRNOG00000051590","protein_coding","chr14:97493658-97496679:-","gi|157818849|ref|NP_001103052.1|",963,{"v":3e-128,"d":"3.00E-128"},"uncharacterized protein C2orf74 homolog [Rattus norvegicus]","gi|157818848|ref|NM_001109582.1|",976,0,"Rattus norvegicus hypothetical protein LOC690352 (LOC690352), mRNA","Q810S2",245,{"v":1E-78,"d":"1.00E-78"},"Uncharacterized protein C2orf74 homolog",".",".",".",".","pfam15484","DUF4642","Domain of unknown function (DUF4642). This family of proteins is found in eukaryotes. Proteins in this family are typically between 115 and 196 amino acids in length.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000065631",11,0.70763482,3,0.193685579,3.653523529,1.869288499,0.02809796,0.013837671,"up","yes","ENSRNOG00000065631","protein_coding","chrX:109596284-109597410:-","gi|50949850|emb|CAH10474.1|",226,{"v":9e-23,"d":"9.00E-23"},"hypothetical protein [Homo sapiens]","gi|56605725|ref|NM_001008324.1|",146,{"v":3e-69,"d":"3.00E-69"},"Rattus norvegicus eukaryotic translation initiation factor 4B (Eif4b), mRNA","Q8BGD9",82,{"v":3e-18,"d":"3.00E-18"},"Eukaryotic translation initiation factor 4B",".",".",".",".","pfam10936","DUF2617","Protein of unknown function DUF2617. This bacterial family of proteins has no known function.",".",".",".",".","."]
["ENSRNOG00000067412",11,0.70763482,3,0.193685579,3.653523529,1.869288499,0.02809796,0.013837671,"up","yes","ENSRNOG00000067412","lncRNA","chr3:22726862-22730706:+","gi|1587031|prf||2205312A",365,{"v":3e-33,"d":"3.00E-33"},"cis-Golgi matrix protein GM130","gi|672016722|ref|XR_344874.2|",1076,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102554600 (LOC102554600), transcript variant X2, ncRNA","Q62839",145,{"v":6E-34,"d":"6.00E-34"},"Golgin subfamily A member 2",".",".",".",".","pfam15070","GOLGA2L5","Putative golgin subfamily A member 2-like protein 5. The function of the GOLGA2L5 protein family remains unknown. This family of proteins is thought to be found in the Golgi apparatus of eukaryotes. Proteins in this family are typically between and 840 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000000975",9,0.578973944,2,0.129123719,4.483869786,2.164744382,0.028857805,0.01417405,"up","yes","Mcoln1","protein_coding","chr12:1560359-1574252:+","gi|564377912|ref|XP_006248817.1|",3028,0,"PREDICTED: mucolipin-1 isoform X2 [Rattus norvegicus]","gi|672071910|ref|XM_006248755.2|",2126,0,"PREDICTED: Rattus norvegicus mucolipin 1 (Mcoln1), transcript variant X2, mRNA","Q99J21",1058,0,"Mucolipin-1",".",".",".",".","pfam08016","PKD_channel","Polycystin cation channel. This family contains the cation channel region of PKD1 and PKD2 proteins.","GO:0019722|calcium-mediated signaling;GO:0051209|release of sequestered calcium ion into cytosol;GO:0051289|protein homotetramerization;GO:0070588|calcium ion transmembrane transport;GO:0071277|cellular response to calcium ion;GO:0071467|cellular response to pH;GO:0090382|phagosome maturation;GO:0097352|autophagosome maturation;GO:0098655|cation transmembrane transport;","GO:0005654|nucleoplasm;GO:0005764|lysosome;GO:0005765|lysosomal membrane;GO:0005770|late endosome;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0010008|endosome membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0043235|receptor complex;GO:0097708|intracellular vesicle;","GO:0042802|identical protein binding;GO:0072345|NAADP-sensitive calcium-release channel activity;GO:0097682|intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity;GO:0099604|ligand-gated calcium channel activity;","K04992","MCOLN1, TRPML1; mucolipin 1"]
["ENSRNOG00000009461",9,0.578973944,2,0.129123719,4.483869786,2.164744382,0.028857805,0.01417405,"up","yes","Scp2d1","protein_coding","chr3:132200744-132212725:+","gi|157821359|ref|NP_001101255.1|",823,{"v":6e-109,"d":"6.00E-109"},"SCP2 sterol-binding domain-containing protein 1 [Rattus norvegicus]","gi|157821358|ref|NM_001107785.1|",615,0,"Rattus norvegicus SCP2 sterol-binding domain containing 1 (Scp2d1), mRNA","Q9DAH1",295,{"v":3e-100,"d":"3.00E-100"},"SCP2 sterol-binding domain-containing protein 1",".",".",".",".","pfam02036","SCP2","SCP-2 sterol transfer family. This domain is involved in binding sterols. It is found in the SCP2 protein, as well as the C terminus of the enzyme estradiol 17 beta-dehydrogenase EC:1.1.1.62. The UNC-24 protein contains an SPFH domain pfam01145.","GO:0006694|steroid biosynthetic process;GO:0015914|phospholipid transport;GO:0032385|positive regulation of intracellular cholesterol transport;",".","GO:0032934|sterol binding;",".","."]
["ENSRNOG00000031344",9,0.578973944,2,0.129123719,4.483869786,2.164744382,0.028857805,0.01417405,"up","yes","AABR07048770.1","protein_coding","chr5:88097665-88098141:-","gi|114145756|ref|NP_001041329.1|",829,{"v":3e-111,"d":"3.00E-111"},"developmental pluripotency-associated protein 3 [Rattus norvegicus]","gi|672052968|ref|XR_592552.1|",477,0,"PREDICTED: Rattus norvegicus developmental pluripotency-associated 3, pseudogene 2 (Dppa3-ps2), misc_RNA","Q6IMK0",323,{"v":1e-112,"d":"1.00E-112"},"Developmental pluripotency-associated protein 3",".",".",".",".","pfam15549","PGC7_Stella","PGC7/Stella/Dppa3 domain. The domain belongs to a fast evolving family known only from the placental mammals. The PGC7/Stella/Dppa3 protein protects imprinted regions from demethylation post-fertilization. This suggests that it might bind methylated DNA sequences directly. The conserved core includes a postively charged helical segment and a C-terminal CXCXXC motif that is predicted to chelate a metal ion. Most placental mammals contain 3-6 paralogs of this domain family. The CXCXXC motif is also conserved in a subset of fungal MBD4-like proteins.",".",".",".",".","."]
["ENSRNOG00000055118",9,0.578973944,2,0.129123719,4.483869786,2.164744382,0.028857805,0.01417405,"up","yes","Gm25820","scaRNA","chr2:174156951-174157078:+",".",".",".",".","gi|354797476|gb|JN961977.1|",113,{"v":4E-51,"d":"4.00E-51"},"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele 2810403A07Rik:tm1a(EUCOMM)Hmgu; transgenic",".",".",".",".",".",".",".",".","pfam01912","eIF-6","eIF-6 family. This family includes eukaryotic translation initiation factor 6 as well as presumed archaebacterial homologues.",".",".",".",".","."]
["ENSRNOG00000062584",9,0.578973944,2,0.129123719,4.483869786,2.164744382,0.028857805,0.01417405,"up","yes","ENSRNOG00000062584","lncRNA","chr4:161157352-161161301:-","gi|26333403|dbj|BAC30419.1|",164,{"v":1e-15,"d":"1.00E-15"},"unnamed protein product [Mus musculus]","gi|672051169|ref|XR_592290.1|",238,{"v":5e-119,"d":"5.00E-119"},"PREDICTED: Rattus norvegicus uncharacterized LOC102556820 (LOC102556820), transcript variant X3, ncRNA",".",".",".",".",".",".",".",".","pfam04749","PLAC8","PLAC8 family. This family includes the Placenta-specific gene 8 protein.",".",".",".",".","."]
["ENSRNOG00000062603",9,0.578973944,2,0.129123719,4.483869786,2.164744382,0.028857805,0.01417405,"up","yes","ENSRNOG00000062603","lncRNA","chr14:95591640-95599406:+","gi|148698732|gb|EDL30679.1|",171,{"v":2e-11,"d":"2.00E-11"},"mCG148064 [Mus musculus]","gi|24366514|emb|AL772195.4|",259,{"v":7e-131,"d":"7.00E-131"},"Mouse DNA sequence from clone RP23-218C5 on chromosome 11, complete sequence",".",".",".",".",".",".",".",".","pfam01221","Dynein_light","Dynein light chain type 1.",".",".",".",".","."]
["ENSRNOG00000064636",9,0.578973944,2,0.129123719,4.483869786,2.164744382,0.028857805,0.01417405,"up","yes","ENSRNOG00000064636","lncRNA","chr7:365492-369191:-","gi|149050529|gb|EDM02702.1|",329,{"v":2e-29,"d":"2.00E-29"},"zinc finger protein 36, C3H type-like 2 [Rattus norvegicus]","gi|672057587|ref|XM_008765049.1|",1298,0,"PREDICTED: Rattus norvegicus zinc finger protein 36, C3H1 type-like 2-like (LOC100911319), transcript variant X1, mRNA","P23949",127,{"v":2e-29,"d":"2.00E-29"},"mRNA decay activator protein ZFP36L2",".",".",".",".","pfam00642","zf-CCCH","Zinc finger C-x8-C-x5-C-x3-H type (and similar).",".",".",".",".","."]
["ENSRNOG00000068793",9,0.578973944,2,0.129123719,4.483869786,2.164744382,0.028857805,0.01417405,"up","yes","ENSRNOG00000068793","protein_coding","chr18:55573642-55573960:-","gi|528759865|gb|EPY79524.1|",304,{"v":4e-31,"d":"4.00E-31"},"proteinase-activated receptor 1 [Camelus ferus]","gi|672041289|ref|XM_008760685.1|",179,{"v":1E-87,"d":"1.00E-87"},"PREDICTED: Rattus norvegicus IQ motif containing GTPase activating protein 2 (Iqgap2), transcript variant X3, mRNA","Q3UQ44",117,{"v":2e-30,"d":"2.00E-30"},"Ras GTPase-activating-like protein IQGAP2",".",".",".",".","pfam03836","RasGAP_C","RasGAP C-terminus.",".",".",".",".","."]
["ENSRNOG00000068851",9,0.578973944,2,0.129123719,4.483869786,2.164744382,0.028857805,0.01417405,"up","yes","ENSRNOG00000068851","lncRNA","chr3:104330477-104340411:+","gi|449269011|gb|EMC79822.1|",167,{"v":2e-10,"d":"2.00E-10"},"hypothetical protein A306_12632, partial [Columba livia]","gi|28372104|emb|AL929110.10|",387,0,"Mouse DNA sequence from clone RP23-275P20 on chromosome 2, complete sequence",".",".",".",".",".",".",".",".","pfam02389","Cornifin","Cornifin (SPRR) family. SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteristic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid.",".",".",".",".","."]
["ENSRNOG00000069150",9,0.578973944,2,0.129123719,4.483869786,2.164744382,0.028857805,0.01417405,"up","yes","U1","snRNA","chr6:72227044-72227207:-","gi|927196956|ref|XP_013836555.1|",275,{"v":1E-26,"d":"1.00E-26"},"PREDICTED: inactive serine/threonine-protein kinase TEX14 [Sus scrofa]","gi|354799381|gb|JN963882.1|",164,{"v":3E-79,"d":"3.00E-79"},"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Tex14:tm1e(EUCOMM)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam02317","Octopine_DH","NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain. This group of enzymes act on the CH-NH substrate bond using NAD(+) or NADP(+) as an acceptor. The Pfam family consists mainly of octopine and nopaline dehydrogenases from Ti plasmids.",".",".",".",".","."]
["ENSRNOG00000033881",16,1.029287011,6,0.387371158,2.657108021,1.40985688,0.030542227,0.014944835,"up","yes","Insyn2a","protein_coding","chr1:189697878-189752922:-","gi|219801793|ref|NP_001137275.1|",2509,0,"protein FAM196A [Rattus norvegicus]","gi|219801792|ref|NM_001143803.1|",4422,0,"Rattus norvegicus family with sequence similarity 196, member A (Fam196a), mRNA",".",".",".",".",".",".",".",".","pfam15265","FAM196","FAM196 family. This protein family is a domain of unknown function. This family of proteins is found in eukaryotes and are typically between 441 and 534 amino acids in length.","GO:0060080|inhibitory postsynaptic potential;","GO:0014069|postsynaptic density;",".",".","."]
["ENSRNOG00000036588",16,1.029287011,6,0.387371158,2.657108021,1.40985688,0.030542227,0.014944835,"up","yes","AC121209.1","protein_coding","chr1:243817905-243818462:-","gi|31560385|ref|NP_062621.2|",792,{"v":3e-105,"d":"3.00E-105"},"60S ribosomal protein L21 [Mus musculus]","gi|189163511|ref|NG_007893.1|",492,0,"Rattus norvegicus ribosomal protein L21, pseudogene 1 (Rpl21-ps1) on chromosome 9","P49666",309,{"v":2e-106,"d":"2.00E-106"},"60S ribosomal protein L21","YBR191w",184,{"v":4e-58,"d":"4.00E-58"},"COG2139","pfam01157","Ribosomal_L21e","Ribosomal protein L21e.",".",".",".",".","."]
["ENSRNOG00000065234",16,1.029287011,6,0.387371158,2.657108021,1.40985688,0.030542227,0.014944835,"up","yes","ENSRNOG00000065234","protein_coding","chr2:222103047-222141520:+","gi|576080555|ref|NP_001276655.1|",1107,{"v":1E-161,"d":"1.00E-161"},"glyceraldehyde-3-phosphate dehydrogenase isoform 1 [Mus musculus]","gi|402691727|ref|NM_017008.4|",881,0,"Rattus norvegicus glyceraldehyde-3-phosphate dehydrogenase (Gapdh), mRNA","P16858",431,{"v":2E-160,"d":"2.00E-160"},"Glyceraldehyde-3-phosphate dehydrogenase","SPBC354.12",325,{"v":4e-115,"d":"4.00E-115"},"COG0057","pfam02800","Gp_dh_C","Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain. GAPDH is a tetrameric NAD-binding enzyme involved in glycolysis and glyconeogenesis. C-terminal domain is a mixed alpha/antiparallel beta fold.",".",".",".",".","."]
["ENSRNOG00000033891",25,1.608260955,12,0.774742316,2.075865642,1.05371307,0.031604081,0.015430047,"up","yes","AABR07045058.1","protein_coding","chr20:31505701-31507171:+","gi|224967128|ref|NP_001009344.2|",1747,0,"transforming growth factor beta regulator 1 [Rattus norvegicus]","gi|672086557|ref|XR_597417.1|",1461,0,"PREDICTED: Rattus norvegicus transforming growth factor beta regulator 1-like (LOC100361475), misc_RNA","Q5PQK8",677,0,"Transforming growth factor beta regulator 1",".",".",".",".","pfam05964","FYRN","F/Y-rich N-terminus. This region is normally found in the trithorax/ALL1 family proteins. It is similar to SMART:SM00541.",".",".",".",".","."]
["ENSRNOG00000052628",25,1.608260955,12,0.774742316,2.075865642,1.05371307,0.031604081,0.015430047,"up","yes","ENSRNOG00000052628","protein_coding","chr18:26356474-26363577:+","gi|393716308|ref|NP_001257345.1|",893,{"v":3e-118,"d":"3.00E-118"},"uncharacterized protein LOC100363294 [Rattus norvegicus]","gi|393716307|ref|NM_001270416.1|",925,0,"Rattus norvegicus stem-loop binding protein-like (LOC100363294), mRNA","Q9YGP6",117,{"v":2e-29,"d":"2.00E-29"},"Oocyte-specific histone RNA stem-loop-binding protein 2",".",".",".",".","pfam15247","SLBP_RNA_bind","Histone RNA hairpin-binding protein RNA-binding domain. This family represents the RNA-binding domain of histone RNA hairpin-binding protein.","GO:0006398|mRNA 3'-end processing by stem-loop binding and cleavage;GO:0051028|mRNA transport;","GO:0005737|cytoplasm;GO:0071204|histone pre-mRNA 3'end processing complex;","GO:0003729|mRNA binding;GO:0071207|histone pre-mRNA stem-loop binding;",".","."]
["ENSRNOG00000069437",25,1.608260955,12,0.774742316,2.075865642,1.05371307,0.031604081,0.015430047,"up","yes","ENSRNOG00000069437","lncRNA","chr3:105821651-105824102:+","gi|33086552|gb|AAP92588.1|",154,1e-07,"Ab2-076 [Rattus norvegicus]","gi|755472881|ref|XR_886101.1|",310,{"v":3e-159,"d":"3.00E-159"},"PREDICTED: Mus musculus uncharacterized LOC105244272 (LOC105244272), transcript variant X1, ncRNA",".",".",".",".",".",".",".",".","pfam14540","NTF-like","Nucleotidyltransferase-like. Structural comparisons with PDB:1kny indicate that this N-terminal domain resembles a nucleotidyltransferase fold.",".",".",".",".","."]
["ENSRNOG00000030910",19,1.222278326,8,0.516494877,2.366486831,1.242746894,0.032458097,0.015822656,"up","yes","Grik4","protein_coding","chr8:42905056-43193751:-","gi|10242377|ref|NP_036704.1|",5007,0,"glutamate receptor ionotropic, kainate 4 precursor [Rattus norvegicus]","gi|10242376|ref|NM_012572.1|",3237,0,"Rattus norvegicus glutamate ionotropic receptor kainate type subunit 4 (Grik4), mRNA","Q01812",1926,0,"Glutamate receptor ionotropic, kainate 4","TM0593",55.8,2e-07,"COG0834","pfam00060","Lig_chan","Ligand-gated ion channel. This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.","GO:0006811|ion transport;GO:0007268|chemical synaptic transmission;GO:0031960|response to corticosteroid;GO:0034220|ion transmembrane transport;GO:0035235|ionotropic glutamate receptor signaling pathway;GO:0035249|synaptic transmission, glutamatergic;GO:0050804|modulation of chemical synaptic transmission;GO:0060078|regulation of postsynaptic membrane potential;","GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0008328|ionotropic glutamate receptor complex;GO:0016020|membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0032983|kainate selective glutamate receptor complex;GO:0042734|presynaptic membrane;GO:0043195|terminal bouton;GO:0043204|perikaryon;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0098686|hippocampal mossy fiber to CA3 synapse;GO:0098978|glutamatergic synapse;GO:0099055|integral component of postsynaptic membrane;GO:0099056|integral component of presynaptic membrane;","GO:0004970|ionotropic glutamate receptor activity;GO:0008066|glutamate receptor activity;GO:0015276|ligand-gated ion channel activity;GO:0015277|kainate selective glutamate receptor activity;GO:0038023|signaling receptor activity;GO:1904315|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K05204","GRIK4; glutamate receptor, ionotropic kainate 4"]
["ENSRNOG00000009599",22,1.41526964,10,0.645618597,2.192114118,1.132322904,0.032565,0.015870705,"up","yes","Rwdd2a","protein_coding","chr8:87536176-87539300:+","gi|157817480|ref|NP_001102243.1|",1375,0,"RWD domain-containing protein 2A [Rattus norvegicus]","gi|157817479|ref|NM_001108773.1|",1513,0,"Rattus norvegicus RWD domain containing 2A (Rwdd2a), mRNA",".",".",".",".",".",".",".",".","pfam06544","DUF1115","Protein of unknown function (DUF1115). This family represents the C-terminus of hypothetical eukaryotic proteins of unknown function.",".",".",".",".","."]
["ENSRNOG00000024918",22,1.41526964,10,0.645618597,2.192114118,1.132322904,0.032565,0.015870705,"up","yes","Fam229b","protein_coding","chr20:42538868-42552248:-","gi|537235612|gb|ERE85265.1|",329,{"v":1E-35,"d":"1.00E-35"},"hypothetical protein H671_2g5373 [Cricetulus griseus]","gi|197927413|ref|NM_001134695.1|",672,0,"Rattus norvegicus family with sequence similarity 229, member B (Fam229b), mRNA",".",".",".",".",".",".",".",".","pfam14982","UPF0731","UPF0731 family. The UPF0731 family of uncharacterized proteins is found in mammals.",".",".",".",".","."]
["ENSRNOG00000068945",22,1.41526964,10,0.645618597,2.192114118,1.132322904,0.032565,0.015870705,"up","yes","ENSRNOG00000068945","lncRNA","chr2:30931621-30933322:+",".",".",".",".","gi|672041314|ref|XR_351331.2|",771,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102553545 (LOC102553545), ncRNA",".",".",".",".",".",".",".",".","pfam13543","KSR1-SAM","SAM like domain present in kinase suppressor RAS 1.",".",".",".",".","."]
["ENSRNOG00000010463",14,0.900626135,5,0.322809298,2.789963422,1.480246208,0.035856555,0.017350495,"up","yes","Cpa4","protein_coding","chr4:59188284-59212255:+","gi|157819247|ref|NP_001102816.1|",2213,0,"carboxypeptidase A4 precursor [Rattus norvegicus]","gi|422011076|ref|NM_001109346.2|",2781,0,"Rattus norvegicus carboxypeptidase A4 (Cpa4), mRNA","Q6P8K8",801,0,"Carboxypeptidase A4","YHR132c",194,{"v":6e-53,"d":"6.00E-53"},"COG2866","pfam00246","Peptidase_M14","Zinc carboxypeptidase.","GO:0006508|proteolysis;","GO:0005615|extracellular space;","GO:0004181|metallocarboxypeptidase activity;GO:0008270|zinc ion binding;","K08637","CPA4; carboxypeptidase A4 [EC:3.4.17.-]"]
["ENSRNOG00000049579",14,0.900626135,5,0.322809298,2.789963422,1.480246208,0.035856555,0.017350495,"up","yes","ENSRNOG00000049579","protein_coding","chrX:139965509-140255887:+","gi|71043648|ref|NP_001019479.1|",299,{"v":6e-33,"d":"6.00E-33"},"uncharacterized protein LOC499742 [Rattus norvegicus]","gi|672032856|ref|XM_006227586.2|",557,0,"PREDICTED: Rattus norvegicus pre-mRNA-splicing factor CWC22 homolog (LOC102549073), mRNA",".",".",".",".",".",".",".",".","pfam01275","Myelin_PLP","Myelin proteolipid protein (PLP or lipophilin).",".",".",".",".","."]
["ENSRNOG00000066549",14,0.900626135,5,0.322809298,2.789963422,1.480246208,0.035856555,0.017350495,"up","yes","ENSRNOG00000066549","protein_coding","chr10:53609400-53611103:-","gi|16758348|ref|NP_446028.1|",717,{"v":4E-92,"d":"4.00E-92"},"peroxiredoxin-6 [Rattus norvegicus]","gi|298896634|emb|FQ218168.1|",276,{"v":7e-141,"d":"7.00E-141"},"Rattus norvegicus TL0ABA8YD06 mRNA sequence","O35244",280,{"v":1e-93,"d":"1.00E-93"},"Peroxiredoxin-6","mll2432",160,{"v":3e-47,"d":"3.00E-47"},"COG0450","pfam00578","AhpC-TSA","AhpC/TSA family. This family contains proteins related to alkyl hydroperoxide reductase (AhpC) and thiol specific antioxidant (TSA).",".",".",".",".","."]
["ENSRNOG00000070952",14,0.900626135,5,0.322809298,2.789963422,1.480246208,0.035856555,0.017350495,"up","yes","ENSRNOG00000070952","protein_coding","chr15:16513382-16609779:-","gi|1791243|gb|AAB41224.1|",486,{"v":8e-75,"d":"8.00E-75"},"ORF2 [Rattus norvegicus]","gi|31455630|gb|AC096039.7|",658,0,"Rattus norvegicus 4 BAC CH230-29I22 (Children's Hospital Oakland Research Institute) complete sequence","P11369",185,{"v":3e-74,"d":"3.00E-74"},"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam12488","DUF3704","Protein of unknown function (DUF3704). This domain family is found in eukaryotes, and is approximately 30 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000004989",17,1.093617449,7,0.451933018,2.419866234,1.2749273,0.039029688,0.018757206,"up","yes","Cst8","protein_coding","chr3:136244636-136251273:+","gi|9506525|ref|NP_062131.1|",659,{"v":2e-84,"d":"2.00E-84"},"cystatin-8 precursor [Rattus norvegicus]","gi|9506524|ref|NM_019258.1|",704,0,"Rattus norvegicus cystatin 8 (Cst8), mRNA","O88969",258,{"v":6e-86,"d":"6.00E-86"},"Cystatin-8",".",".",".",".","pfam00031","Cystatin","Cystatin domain. Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 are related to this family but have not been included.","GO:0010951|negative regulation of endopeptidase activity;","GO:0005576|extracellular region;GO:0005737|cytoplasm;GO:0009986|cell surface;","GO:0004869|cysteine-type endopeptidase inhibitor activity;","K13904","CST8; cystatin-8"]
["ENSRNOG00000043019",17,1.093617449,7,0.451933018,2.419866234,1.2749273,0.039029688,0.018757206,"up","yes","Btnl10","protein_coding","chr10:43694073-43700926:+","gi|392331746|ref|XP_003752381.1|",2482,0,"PREDICTED: butyrophilin-like protein 10 [Rattus norvegicus]","gi|672068115|ref|XM_006246534.2|",2666,0,"PREDICTED: Rattus norvegicus similar to butyrophilin related 1 (RGD1559732), transcript variant X1, mRNA","Q9JK39",429,{"v":8e-142,"d":"8.00E-142"},"Butyrophilin-like protein 10",".",".",".",".","pfam00622","SPRY","SPRY domain. SPRY Domain is named from SPla and the RYanodine Receptor. Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.","GO:0001817|regulation of cytokine production;GO:0050852|T cell receptor signaling pathway;","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0005102|signaling receptor binding;","K06712","BTN, CD277; butyrophilin"]
["ENSRNOG00000063647",17,1.093617449,7,0.451933018,2.419866234,1.2749273,0.039029688,0.018757206,"up","yes","ENSRNOG00000063647","protein_coding","chrX:134320773-134325672:+","gi|537128405|gb|ERE65415.1|",294,{"v":3e-30,"d":"3.00E-30"},"protein DDX26B [Cricetulus griseus]","gi|755490553|ref|XM_006544571.2|",237,{"v":2E-119,"d":"2.00E-119"},"PREDICTED: Mus musculus predicted gene 10477 (Gm10477), mRNA","Q5JSJ4",68.9,{"v":2E-12,"d":"2.00E-12"},"Integrator complex subunit 6-like",".",".",".",".","pfam15300","INT_SG_DDX_CT_C","INTS6/SAGE1/DDX26B/CT45 C-terminus. This domain is found at the C-terminus of integrator complex subunit 6 (INTS6), sarcoma antigen 1 (SAGE1), protein DDX26B (DDX26B) and members of the cancer/testis antigen family 45.",".",".",".",".","."]
["ENSRNOG00000067308",17,1.093617449,7,0.451933018,2.419866234,1.2749273,0.039029688,0.018757206,"up","yes","ENSRNOG00000067308","protein_coding","chr1:67553726-67555499:-","gi|564296772|ref|XP_006223098.1|",400,{"v":1e-47,"d":"1.00E-47"},"PREDICTED: zinc finger protein 582-like isoform X1 [Rattus norvegicus]","gi|672013065|ref|XM_006223036.2|",227,{"v":5e-114,"d":"5.00E-114"},"PREDICTED: Rattus norvegicus zinc finger protein 582-like (LOC102548162), transcript variant X1, mRNA","Q96NG8",114,{"v":2e-29,"d":"2.00E-29"},"Zinc finger protein 582",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000063126",20,1.286608764,9,0.581056737,2.214256684,1.146822474,0.03950833,0.018976058,"up","yes","ENSRNOG00000063126","lncRNA","chr11:29437492-29456542:-",".",".",".",".","gi|672025864|ref|XR_601265.1|",742,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103693514 (LOC103693514), ncRNA",".",".",".",".",".",".",".",".","pfam13705","TRC8_N","TRC8 N-terminal domain. This region is found at the N-terminus of the TRC8 protein. TRC8 is an E3 ubiquitin-protein ligase also known as RNF139. This region contains 12 transmembrane domains. This region has been suggested to contain a sterol sensing domain. It has been found that TRC8 protein levels are sterol responsive and that it binds and stimulates ubiquitylation of the endoplasmic reticulum anchor protein INSIG.",".",".",".",".","."]
["ENSRNOG00000001416",5,0.321652191,0,0.03228093,9.96415508,3.316747476,0.04094083,0.019417518,"up","yes","Vgf","protein_coding","chr12:19637320-19640341:-","gi|564378870|ref|XP_006249199.1|",1825,0,"PREDICTED: neurosecretory protein VGF isoform X2 [Rattus norvegicus]","gi|13591863|ref|NM_030997.1|",2636,0,"Rattus norvegicus VGF nerve growth factor inducible (Vgf), mRNA","P20156",691,0,"Neurosecretory protein VGF",".",".",".",".","pfam15279","SOBP","Sine oculis-binding protein. SOBP is associated with syndromic and nonsyndromic intellectual disability. It carries a zinc-finger of the zf-C2H2 type at the N-terminus, and a highly characteristic C-terminal PhPhPhPhPhPh motif. The deduced 873-amino acid protein contains an N-terminal nuclear localisation signal (NLS), followed by 2 FCS-type zinc finger motifs, a proline-rich region (PR1), a putative RNA-binding motif region, and a C-terminal NLS embedded in a second proline-rich motif. SOBP is expressed in various human tissues, including developing mouse brain at embryonic day 14. In postnatal and adult mouse brain SOBP is expressed in all neurons, with intense staining in the limbic system. Highest expression is in layer V cortical neurons, hippocampus, pyriform cortex, dorsomedial nucleus of thalamus, amygdala, and hypothalamus. Postnatal expression of SOBP in the limbic system corresponds to a time of active synaptogenesis. the family is also referred to as Jackson circler, JXC1. In seven affected siblings from a consanguineous Israeli Arab family with mental retardation, anterior maxillary protrusion, and strabismus mutations were found in this protein.","GO:0001541|ovarian follicle development;GO:0002021|response to dietary excess;GO:0006091|generation of precursor metabolites and energy;GO:0007165|signal transduction;GO:0009409|response to cold;GO:0019953|sexual reproduction;GO:0030073|insulin secretion;GO:0030182|neuron differentiation;GO:0032868|response to insulin;GO:0033500|carbohydrate homeostasis;GO:0042593|glucose homeostasis;GO:0043084|penile erection;GO:0048167|regulation of synaptic plasticity;GO:0048168|regulation of neuronal synaptic plasticity;GO:0051591|response to cAMP;","GO:0005615|extracellular space;GO:0005794|Golgi apparatus;GO:0030133|transport vesicle;GO:0030667|secretory granule membrane;GO:0031410|cytoplasmic vesicle;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043231|intracellular membrane-bounded organelle;GO:0045202|synapse;","GO:0005179|hormone activity;GO:0005184|neuropeptide hormone activity;GO:0008083|growth factor activity;","K25695","VGF; neurosecretory protein VGF"]
["ENSRNOG00000001691",5,0.321652191,0,0.03228093,9.96415508,3.316747476,0.04094083,0.019417518,"up","yes","Cldn14","protein_coding","chr11:33232220-33329171:-","gi|355560293|gb|EHH16979.1|",914,{"v":2e-117,"d":"2.00E-117"},"Claudin-14 [Macaca mulatta]","gi|672070590|ref|XM_006248058.2|",1456,0,"PREDICTED: Rattus norvegicus claudin 14 (Cldn14), transcript variant X1, mRNA","Q9Z0S3",344,{"v":4e-114,"d":"4.00E-114"},"Claudin-14",".",".",".",".","pfam00822","PMP22_Claudin","PMP-22/EMP/MP20/Claudin family.","GO:0007155|cell adhesion;GO:0008150|biological_process;GO:0070830|bicellular tight junction assembly;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0005923|bicellular tight junction;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0005198|structural molecule activity;","K06087","CLDN; claudin"]
["ENSRNOG00000007456",5,0.321652191,0,0.03228093,9.96415508,3.316747476,0.04094083,0.019417518,"up","yes","Calb1","protein_coding","chr5:29375642-29402431:+","gi|110590202|pdb|2G9B|A",1363,0,"Chain A, Nmr Solution Structure Of Ca2+-Loaded Calbindin D28k","gi|130492139|ref|NM_031984.2|",1704,0,"Rattus norvegicus calbindin 1 (Calb1), mRNA","P07171",529,0,"Calbindin",".",".",".",".","pfam13499","EF-hand_7","EF-hand domain pair.","GO:0007611|learning or memory;GO:0007614|short-term memory;GO:0007616|long-term memory;GO:0007626|locomotory behavior;GO:0010842|retina layer formation;GO:0035502|metanephric part of ureteric bud development;GO:0042359|vitamin D metabolic process;GO:0048167|regulation of synaptic plasticity;GO:0051480|regulation of cytosolic calcium ion concentration;GO:0060041|retina development in camera-type eye;GO:0071310|cellular response to organic substance;GO:0072205|metanephric collecting duct development;GO:0072221|metanephric distal convoluted tubule development;GO:0072286|metanephric connecting tubule development;GO:0090102|cochlea development;GO:0099509|regulation of presynaptic cytosolic calcium ion concentration;GO:0099566|regulation of postsynaptic cytosolic calcium ion concentration;GO:1900271|regulation of long-term synaptic potentiation;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0030424|axon;GO:0030425|dendrite;GO:0032420|stereocilium;GO:0032437|cuticular plate;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0043197|dendritic spine;GO:0044297|cell body;GO:0044305|calyx of Held;GO:0045202|synapse;GO:0098686|hippocampal mossy fiber to CA3 synapse;GO:0098794|postsynapse;GO:0098978|glutamatergic synapse;GO:0098982|GABA-ergic synapse;GO:0099523|presynaptic cytosol;GO:0099524|postsynaptic cytosol;","GO:0005499|vitamin D binding;GO:0005509|calcium ion binding;GO:0008270|zinc ion binding;GO:0099534|calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration;GO:0099567|calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration;","K14757","CALB1, CALB; calbindin"]
["ENSRNOG00000008914",5,0.321652191,0,0.03228093,9.96415508,3.316747476,0.04094083,0.019417518,"up","yes","AABR07049348.1","pseudogene","chr5:113976353-113976705:+","gi|26338059|dbj|BAC32715.1|",385,{"v":2E-45,"d":"2.00E-45"},"unnamed protein product [Mus musculus]","gi|672019620|ref|XR_346633.2|",313,{"v":9e-162,"d":"9.00E-162"},"PREDICTED: Rattus norvegicus uncharacterized LOC102556219 (LOC102556219), ncRNA",".",".",".",".",".",".",".",".","pfam15552","DUF4657","Domain of unknown function (DUF4657). This family of proteins is found in eukaryotes. Proteins in this family are typically between 305 and 370 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000020212",5,0.321652191,0,0.03228093,9.96415508,3.316747476,0.04094083,0.019417518,"up","yes","Prr35","protein_coding","chr10:14962162-14964152:-","gi|392331674|ref|XP_003752356.1|",2391,0,"PREDICTED: proline-rich protein 35 [Rattus norvegicus]","gi|672024625|ref|XM_003752308.3|",1713,0,"PREDICTED: Rattus norvegicus similar to tripartite motif protein 32 (LOC302999), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam15269","zf-C2H2_7","Zinc-finger. this is a family of eukaryotic zinc-fingers.",".",".",".",".","."]
["ENSRNOG00000020538",5,0.321652191,0,0.03228093,9.96415508,3.316747476,0.04094083,0.019417518,"up","yes","AC121639.1","protein_coding","chr1:80970586-80971373:+","gi|26347045|dbj|BAC37171.1|",517,{"v":2e-64,"d":"2.00E-64"},"unnamed protein product [Mus musculus]","gi|395132479|ref|NR_073028.1|",226,{"v":3e-113,"d":"3.00E-113"},"Mus musculus RIKEN cDNA 4732471J01 gene (4732471J01Rik), transcript variant 3, long non-coding RNA","P15304",201,{"v":5e-59,"d":"5.00E-59"},"Hormone-sensitive lipase",".",".",".",".","pfam06350","HSL_N","Hormone-sensitive lipase (HSL) N-terminus. This family consists of several mammalian hormone-sensitive lipase (HSL) proteins (EC:3.1.1.-). Hormone-sensitive lipase, a key enzyme in fatty acid mobilisation, overall energy homeostasis, and possibly steroidogenesis, is acutely controlled through reversible phosphorylation by catecholamines and insulin.",".",".",".",".","."]
["ENSRNOG00000032353",5,0.321652191,0,0.03228093,9.96415508,3.316747476,0.04094083,0.019417518,"up","yes","Mmp1","protein_coding","chr8:4658588-4679097:+","gi|197384336|ref|NP_001128002.1|",2359,0,"matrix metallopeptidase 1a precursor [Rattus norvegicus]","gi|197384335|ref|NM_001134530.1|",1994,0,"Rattus norvegicus matrix metallopeptidase 1 (Mmp1), mRNA","Q9EPL5",819,0,"Interstitial collagenase A",".",".",".",".","pfam00413","Peptidase_M10","Matrixin. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.","GO:0001553|luteinization;GO:0001554|luteolysis;GO:0006508|proteolysis;GO:0009410|response to xenobiotic stimulus;GO:0009612|response to mechanical stimulus;GO:0010763|positive regulation of fibroblast migration;GO:0014854|response to inactivity;GO:0014911|positive regulation of smooth muscle cell migration;GO:0030574|collagen catabolic process;GO:0031334|positive regulation of protein complex assembly;GO:0071222|cellular response to lipopolysaccharide;GO:0071283|cellular response to iron(III) ion;GO:0071305|cellular response to vitamin D;GO:0071312|cellular response to alkaloid;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071375|cellular response to peptide hormone stimulus;GO:0071407|cellular response to organic cyclic compound;GO:0071466|cellular response to xenobiotic stimulus;GO:0071492|cellular response to UV-A;GO:0071498|cellular response to fluid shear stress;GO:0071680|response to indole-3-methanol;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0031012|extracellular matrix;","GO:0004175|endopeptidase activity;GO:0004222|metalloendopeptidase activity;GO:0004252|serine-type endopeptidase activity;GO:0005515|protein binding;GO:0008233|peptidase activity;GO:0008237|metallopeptidase activity;GO:0008270|zinc ion binding;","K01388","MMP1; matrix metalloproteinase-1 (interstitial collagenase) [EC:3.4.24.7]"]
["ENSRNOG00000035567",5,0.321652191,0,0.03228093,9.96415508,3.316747476,0.04094083,0.019417518,"up","yes","Mir30c1","miRNA","chr5:134349237-134349325:-",".",".",".",".","gi|262205484|ref|NR_029716.1|",89,{"v":6e-38,"d":"6.00E-38"},"Mus musculus microRNA 30c-1 (Mir30c-1), microRNA",".",".",".",".",".",".",".",".","pfam06460","NSP13","Coronavirus NSP13. This family covers the NSP13 region of the coronavirus polyprotein. This protein has the predicted function of an mRNA cap-1 methyltransferase function.","GO:0009617|response to bacterium;GO:0010629|negative regulation of gene expression;GO:0045668|negative regulation of osteoblast differentiation;GO:0060291|long-term synaptic potentiation;GO:0071222|cellular response to lipopolysaccharide;GO:0071241|cellular response to inorganic substance;GO:1904322|cellular response to forskolin;","GO:0016442|RISC complex;",".","K17040","MIR30C; microRNA 30c"]
["ENSRNOG00000046368",5,0.321652191,0,0.03228093,9.96415508,3.316747476,0.04094083,0.019417518,"up","yes","Dusp14l1","protein_coding","chr2:138738101-138739486:-","gi|392338778|ref|XP_003753637.1|",1066,{"v":1E-141,"d":"1.00E-141"},"PREDICTED: dual specificity protein phosphatase 14-like [Rattus norvegicus]","gi|672042442|ref|XM_003749277.3|",1354,0,"PREDICTED: Rattus norvegicus dual specificity phosphatase 14-like 1 (Dusp14l1), mRNA","Q9JLY7",408,{"v":2E-140,"d":"2.00E-140"},"Dual specificity protein phosphatase 14","YIL113w",76.3,{"v":6e-15,"d":"6.00E-15"},"COG2453","pfam00782","DSPc","Dual specificity phosphatase, catalytic domain. Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a \"recognition\" region.","GO:0035335|peptidyl-tyrosine dephosphorylation;",".","GO:0004725|protein tyrosine phosphatase activity;GO:0017017|MAP kinase tyrosine/serine/threonine phosphatase activity;","K14165","K14165; atypical dual specificity phosphatase [EC:3.1.3.16 3.1.3.48]"]
["ENSRNOG00000047125",5,0.321652191,0,0.03228093,9.96415508,3.316747476,0.04094083,0.019417518,"up","yes","Foxl1","protein_coding","chr19:49197400-49198425:+","gi|564321597|ref|XP_006222839.1|",1354,0,"PREDICTED: forkhead box protein L1 [Rattus norvegicus]","gi|672031372|ref|XM_006222777.2|",1026,0,"PREDICTED: Rattus norvegicus similar to Forkhead box protein L1 (Forkhead-related protein FKHL11) (Transcription factor FKH-6) (LOC687553), mRNA","Q64731",463,{"v":5e-162,"d":"5.00E-162"},"Forkhead box protein L1","SPBC4C3.05",102,{"v":8e-23,"d":"8.00E-23"},"COG5025","pfam00250","Fork_head","Fork head domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0007495|visceral mesoderm-endoderm interaction involved in midgut development;GO:0007507|heart development;GO:0009653|anatomical structure morphogenesis;GO:0030111|regulation of Wnt signaling pathway;GO:0030154|cell differentiation;GO:0030166|proteoglycan biosynthetic process;GO:0061146|Peyer's patch morphogenesis;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0043565|sequence-specific DNA binding;","K09405","FOXL; forkhead box protein L"]
["ENSRNOG00000047578",5,0.321652191,0,0.03228093,9.96415508,3.316747476,0.04094083,0.019417518,"up","yes","Ccdc28b","protein_coding","chr5:141962276-141967382:-","gi|672054196|ref|XP_008762393.1|",845,{"v":2e-108,"d":"2.00E-108"},"PREDICTED: coiled-coil domain-containing protein 28B isoform X1 [Rattus norvegicus]","gi|672054195|ref|XM_008764171.1|",747,0,"PREDICTED: Rattus norvegicus coiled coil domain containing 28B (Ccdc28b), transcript variant X1, mRNA","Q8CEG5",307,{"v":2e-102,"d":"2.00E-102"},"Coiled-coil domain-containing protein 28B",".",".",".",".","pfam13270","DUF4061","Domain of unknown function (DUF4061). This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is approximately 90 amino acids in length. There is a conserved AFG sequence motif.","GO:0008150|biological_process;GO:0060271|cilium assembly;","GO:0005575|cellular_component;GO:0005813|centrosome;","GO:0003674|molecular_function;",".","."]
["ENSRNOG00000058967",5,0.321652191,0,0.03228093,9.96415508,3.316747476,0.04094083,0.019417518,"up","yes","U6","snRNA","chr1:164181113-164181219:+","gi|965792038|ref|XP_014963564.1|",134,3e-08,"PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC106992171 [Ovis aries musimon]","gi|21425260|emb|AL731728.10|",66,{"v":5e-25,"d":"5.00E-25"},"Mouse DNA sequence from clone RP24-531N10 on chromosome 11, complete sequence",".",".",".",".",".",".",".",".","pfam05783","DLIC","Dynein light intermediate chain (DLIC). This family consists of several eukaryotic dynein light intermediate chain proteins. The light intermediate chains (LICs) of cytoplasmic dynein consist of multiple isoforms, which undergo post-translational modification to produce a large number of species. DLIC1 is known to be involved in assembly, organisation, and function of centrosomes and mitotic spindles when bound to pericentrin. DLIC2 is a subunit of cytoplasmic dynein 2 that may play a role in maintaining Golgi organisation by binding cytoplasmic dynein 2 to its Golgi-associated cargo.",".",".",".",".","."]
["ENSRNOG00000060355",5,0.321652191,0,0.03228093,9.96415508,3.316747476,0.04094083,0.019417518,"up","yes","H1f5","protein_coding","chr17:42726127-42769160:+","gi|157821427|ref|NP_001102887.1|",325,{"v":1e-31,"d":"1.00E-31"},"histone H1.5 [Rattus norvegicus]","gi|157821426|ref|NM_001109417.1|",669,0,"Rattus norvegicus histone cluster 1, H1b (Hist1h1b), mRNA","D3ZBN0",129,{"v":4e-33,"d":"4.00E-33"},"Histone H1.5",".",".",".",".","pfam00538","Linker_histone","linker histone H1 and H5 family. Linker histone H1 is an essential component of chromatin structure. H1 links nucleosomes into higher order structures Histone H1 is replaced by histone H5 in some cell types.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006325|chromatin organization;GO:0006334|nucleosome assembly;GO:0007517|muscle organ development;GO:0016584|nucleosome positioning;GO:0030261|chromosome condensation;GO:0030307|positive regulation of cell growth;GO:0045910|negative regulation of DNA recombination;GO:0050821|protein stabilization;GO:0051574|positive regulation of histone H3-K9 methylation;GO:0071169|establishment of protein localization to chromatin;","GO:0000785|chromatin;GO:0000786|nucleosome;GO:0000792|heterochromatin;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0003690|double-stranded DNA binding;GO:0031490|chromatin DNA binding;GO:0031492|nucleosomal DNA binding;GO:0042826|histone deacetylase binding;","K11275","H1_5; histone H1/5"]
["ENSRNOG00000063059",5,0.321652191,0,0.03228093,9.96415508,3.316747476,0.04094083,0.019417518,"up","yes","Olr167","protein_coding","chr1:159075031-159075990:-","gi|47576625|ref|NP_001000173.1|",1478,0,"olfactory receptor Olr167 [Rattus norvegicus]","gi|90855788|gb|AC128039.4|",960,0,"Rattus norvegicus BAC CH230-394A24 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q8NGI1",439,{"v":5e-153,"d":"5.00E-153"},"Putative olfactory receptor 56B2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.",".",".",".",".","."]
["ENSRNOG00000063450",5,0.321652191,0,0.03228093,9.96415508,3.316747476,0.04094083,0.019417518,"up","yes","Nrg3","protein_coding","chr16:14235157-15352368:-","gi|223460986|gb|AAI37839.1|",2912,0,"Neuregulin 3 [Mus musculus]","gi|298231175|ref|NM_008734.3|",2869,0,"Mus musculus neuregulin 3 (Nrg3), transcript variant 1, mRNA","O35181",1126,0,"Pro-neuregulin-3, membrane-bound isoform",".",".",".",".","pfam02158","Neuregulin","Neuregulin family.",".",".",".",".","."]
["ENSRNOG00000063546",5,0.321652191,0,0.03228093,9.96415508,3.316747476,0.04094083,0.019417518,"up","yes","ENSRNOG00000063546","lncRNA","chr17:52366830-52426157:-",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","pfam02705","K_trans","K+ potassium transporter. This is a family of K+ potassium transporters that are conserved across phyla, having both bacterial (KUP), yeast (HAK), and plant (AtKT) sequences as members.",".",".",".",".","."]
["ENSRNOG00000063593",5,0.321652191,0,0.03228093,9.96415508,3.316747476,0.04094083,0.019417518,"up","yes","ENSRNOG00000063593","lncRNA","chr7:90831219-90833380:-",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","pfam14745","WASH-7_N","WASH complex subunit 7, N-terminal. This family is the conserved N-terminal region of proteins that form subunit 7 of the WASH complex. In species such as Drosophila this protein is the only component of the 'complex'. This complex is a nucleation promoting factor necessary for the activation of Arp2/3 that nucleates and organizes actin filaments by associating with a pre-existing filament to induce the assembly of a branching filament. WASH thus effectively nucleates actin on endosomes.",".",".",".",".","."]
["ENSRNOG00000063643",5,0.321652191,0,0.03228093,9.96415508,3.316747476,0.04094083,0.019417518,"up","yes","ENSRNOG00000063643","pseudogene","chr6:103651386-103651852:-","gi|704246978|ref|XP_010146640.1|",489,{"v":3e-60,"d":"3.00E-60"},"PREDICTED: 60S ribosomal protein L23a, partial [Eurypyga helias]","gi|334358929|gb|AC097863.7|",366,0,"Rattus norvegicus BAC CH230-84I23 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P62752",188,{"v":7e-60,"d":"7.00E-60"},"60S ribosomal protein L23a","YOL127w",122,{"v":7e-35,"d":"7.00E-35"},"COG0089","pfam00276","Ribosomal_L23","Ribosomal protein L23.",".",".",".",".","."]
["ENSRNOG00000064068",5,0.321652191,0,0.03228093,9.96415508,3.316747476,0.04094083,0.019417518,"up","yes","ENSRNOG00000064068","protein_coding","chr15:47570820-47636167:-","gi|755687372|ref|XP_011280011.1|",9222,0,"PREDICTED: SCO-spondin-like [Felis catus]","gi|568900760|ref|XM_006543187.1|",3980,0,"PREDICTED: Mus musculus uncharacterized LOC675947 (LOC675947), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam07699","GCC2_GCC3","GCC2 and GCC3.",".",".",".",".","."]
["ENSRNOG00000064881",5,0.321652191,0,0.03228093,9.96415508,3.316747476,0.04094083,0.019417518,"up","yes","ENSRNOG00000064881","lncRNA","chr7:17236582-17250869:-",".",".",".",".","gi|672058306|ref|XR_593300.1|",1986,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103692791 (LOC103692791), ncRNA",".",".",".",".",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.",".",".",".",".","."]
["ENSRNOG00000066446",5,0.321652191,0,0.03228093,9.96415508,3.316747476,0.04094083,0.019417518,"up","yes","ENSRNOG00000066446","protein_coding","chr3:22428219-22429612:+","gi|157822143|ref|NP_001101871.1|",398,{"v":1e-43,"d":"1.00E-43"},"GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase [Rattus norvegicus]","gi|67678036|gb|BC097962.1|",211,{"v":5e-105,"d":"5.00E-105"},"Rattus norvegicus cDNA clone IMAGE:7387549, containing frame-shift errors","Q3TZM9",147,{"v":2E-41,"d":"2.00E-41"},"GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase","SPCC330.08",52.8,4e-08,"COG0438","pfam13268","DUF4059","Protein of unknown function (DUF4059). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 70 amino acids in length. There is a conserved DKT sequence motif.",".",".",".",".","."]
["ENSRNOG00000066545",5,0.321652191,0,0.03228093,9.96415508,3.316747476,0.04094083,0.019417518,"up","yes","Olr834","protein_coding","chr5:57960219-57965853:-","gi|47576769|ref|NP_001000407.1|",1542,0,"olfactory receptor Olr834 [Rattus norvegicus]","gi|25136988|emb|AL732626.8|",1795,0,"Mouse DNA sequence from clone RP23-191F22 on chromosome 4, complete sequence","Q8NGT2",487,{"v":5e-157,"d":"5.00E-157"},"Olfactory receptor 13J1",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.",".",".",".",".","."]
["ENSRNOG00000066981",5,0.321652191,0,0.03228093,9.96415508,3.316747476,0.04094083,0.019417518,"up","yes","ENSRNOG00000066981","protein_coding","chr16:20083155-20248231:-","gi|672029288|ref|XP_008770139.1|",1261,{"v":2e-148,"d":"2.00E-148"},"PREDICTED: uncharacterized protein RGD1564941 isoform X2 [Rattus norvegicus]","gi|672080031|ref|XM_008771215.1|",2482,0,"PREDICTED: Rattus norvegicus similar to ankyrin-like protein (RGD1563748), transcript variant X3, mRNA","Q811D2",144,{"v":7e-33,"d":"7.00E-33"},"Ankyrin repeat domain-containing protein 26","SPAC2F7.10_1",72.8,{"v":2E-12,"d":"2.00E-12"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).",".",".",".",".","."]
["ENSRNOG00000067046",5,0.321652191,0,0.03228093,9.96415508,3.316747476,0.04094083,0.019417518,"up","yes","ENSRNOG00000067046","protein_coding","chr9:2785787-2794154:+","gi|564310981|ref|XP_006226724.1|",904,{"v":7e-118,"d":"7.00E-118"},"PREDICTED: disks large homolog 5-like isoform X1 [Rattus norvegicus]","gi|71043739|ref|NM_001025755.1|",1081,0,"Rattus norvegicus similar to RIKEN cDNA 1700001E04 (MGC116197), mRNA",".",".",".",".",".",".",".",".","pfam04822","Takusan","Takusan. This domain is named takusan, which is a Japanese word meaning 'many'. Members of this family regulate synaptic activity.",".",".",".",".","."]
["ENSRNOG00000067111",5,0.321652191,0,0.03228093,9.96415508,3.316747476,0.04094083,0.019417518,"up","yes","ENSRNOG00000067111","protein_coding","chr14:13850057-13852806:-","gi|672027701|ref|XP_008762845.1|",999,{"v":7e-132,"d":"7.00E-132"},"PREDICTED: PRAME family member 12-like isoform X1 [Rattus norvegicus]","gi|672027702|ref|XM_002724946.2|",566,0,"PREDICTED: Rattus norvegicus similar to PRAME family member 9 (LOC685782), transcript variant X2, mRNA","O95522",144,{"v":8e-38,"d":"8.00E-38"},"PRAME family member 12",".",".",".",".","pfam12799","LRR_4","Leucine Rich repeats (2 copies). Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.",".",".",".",".","."]
["ENSRNOG00000067810",5,0.321652191,0,0.03228093,9.96415508,3.316747476,0.04094083,0.019417518,"up","yes","Olr287","protein_coding","chr1:194973745-194980682:+","gi|27545426|ref|NP_775456.1|",1458,0,"olfactory receptor 287 [Rattus norvegicus]","gi|55168455|gb|AC109205.12|",1080,0,"Mus musculus chromosome 7, clone RP23-137A4, complete sequence","P23267",566,0,"Olfactory receptor 287",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.",".",".",".",".","."]
["ENSRNOG00000068538",5,0.321652191,0,0.03228093,9.96415508,3.316747476,0.04094083,0.019417518,"up","yes","ENSRNOG00000068538","protein_coding","chr3:164943258-164944393:+","gi|149034077|gb|EDL88860.1|",1126,{"v":6E-153,"d":"6.00E-153"},"rCG64216, partial [Rattus norvegicus]","gi|672048370|ref|XM_008762577.1|",460,0,"PREDICTED: Rattus norvegicus zinc finger protein 239-like (LOC103691980), partial mRNA","Q8BZW4",357,{"v":7e-120,"d":"7.00E-120"},"Zinc finger protein 120",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.",".",".",".",".","."]
["ENSRNOG00000069208",5,0.321652191,0,0.03228093,9.96415508,3.316747476,0.04094083,0.019417518,"up","yes","ENSRNOG00000069208","pseudogene","chr3:2233522-2234359:-","gi|672034032|ref|XP_008756887.1|",577,{"v":1e-69,"d":"1.00E-69"},"PREDICTED: serine/arginine repetitive matrix protein 1-like [Rattus norvegicus]","gi|374429560|ref|NR_046239.1|",674,0,"Rattus norvegicus 45S pre-ribosomal RNA (Rn45s), ribosomal RNA",".",".",".",".",".",".",".",".","pfam07420","DUF1509","Protein of unknown function (DUF1509). This family consists of several uncharacterized viral proteins from the Marek's disease-like viruses. Members of this family are typically around 400 residues in length. The function of this family is unknown.",".",".",".",".","."]
["ENSRNOG00000069609",5,0.321652191,0,0.03228093,9.96415508,3.316747476,0.04094083,0.019417518,"up","yes","ENSRNOG00000069609","lncRNA","chr19:44412478-44418669:-","gi|440901667|gb|ELR52566.1|",652,{"v":4e-80,"d":"4.00E-80"},"40S ribosomal protein S14, partial [Bos mutus]","gi|298896846|emb|FQ221312.1|",375,0,"Rattus norvegicus TL0ADA38YA10 mRNA sequence","P62264",247,{"v":3e-78,"d":"3.00E-78"},"40S ribosomal protein S14","YCR031c",174,{"v":3E-51,"d":"3.00E-51"},"COG0100","pfam00411","Ribosomal_S11","Ribosomal protein S11.",".",".",".",".","."]
["ENSRNOG00000070082",5,0.321652191,0,0.03228093,9.96415508,3.316747476,0.04094083,0.019417518,"up","yes","ENSRNOG00000070082","protein_coding","chr5:157866501-157868689:+","gi|672020101|ref|XP_008774341.1|",1867,0,"PREDICTED: zinc finger protein 431-like [Rattus norvegicus]","gi|672020100|ref|XM_008776119.1|",794,0,"PREDICTED: Rattus norvegicus zinc finger protein 665-like (LOC102557083), mRNA","Q96NI8",346,{"v":8e-112,"d":"8.00E-112"},"Zinc finger protein 570",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.",".",".",".",".","."]
["ENSRNOG00000070257",5,0.321652191,0,0.03228093,9.96415508,3.316747476,0.04094083,0.019417518,"up","yes","ENSRNOG00000070257","protein_coding","chr1:284652-287551:-","gi|672070366|ref|XP_008766739.1|",2448,0,"PREDICTED: zinc finger protein 431-like isoform X3 [Rattus norvegicus]","gi|672070365|ref|XM_008768517.1|",1382,0,"PREDICTED: Rattus norvegicus zinc finger protein 120-like (LOC102548076), transcript variant X3, mRNA","E9QAG8",638,0,"Zinc finger protein 431",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000070420",5,0.321652191,0,0.03228093,9.96415508,3.316747476,0.04094083,0.019417518,"up","yes","ENSRNOG00000070420","protein_coding","chr19:21951768-22072838:-","gi|62079279|ref|NP_001014293.1|",1627,0,"uncharacterized protein LOC367515 [Rattus norvegicus]","gi|62079278|ref|NM_001014271.1|",953,0,"Rattus norvegicus similar to RIKEN cDNA 1700081O22 (LOC367515), mRNA",".",".",".",".",".",".",".",".","pfam00612","IQ","IQ calmodulin-binding motif. Calmodulin-binding motif.",".",".",".",".","."]
["ENSRNOG00000002919",12,0.771965258,4,0.258247439,2.989246524,1.579781881,0.041543284,0.019677107,"up","yes","Gfap","protein_coding","chr10:87852890-87861589:-","gi|158186732|ref|NP_058705.2|",2180,0,"glial fibrillary acidic protein [Rattus norvegicus]","gi|158186731|ref|NM_017009.2|",2688,0,"Rattus norvegicus glial fibrillary acidic protein (Gfap), mRNA","P47819",822,0,"Glial fibrillary acidic protein",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0006886|intracellular protein transport;GO:0009611|response to wounding;GO:0010467|gene expression;GO:0010625|positive regulation of Schwann cell proliferation;GO:0010977|negative regulation of neuron projection development;GO:0014002|astrocyte development;GO:0030198|extracellular matrix organization;GO:0031102|neuron projection regeneration;GO:0045103|intermediate filament-based process;GO:0045109|intermediate filament organization;GO:0051580|regulation of neurotransmitter uptake;GO:0060020|Bergmann glial cell differentiation;GO:0060252|positive regulation of glial cell proliferation;GO:0060291|long-term synaptic potentiation;GO:0070779|D-aspartate import across plasma membrane;GO:1904714|regulation of chaperone-mediated autophagy;","GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0005765|lysosomal membrane;GO:0005856|cytoskeleton;GO:0005882|intermediate filament;GO:0016020|membrane;GO:0042995|cell projection;GO:0044297|cell body;GO:0045111|intermediate filament cytoskeleton;GO:0097386|glial cell projection;GO:0097449|astrocyte projection;GO:0097450|astrocyte end-foot;GO:0098574|cytoplasmic side of lysosomal membrane;","GO:0005178|integrin binding;GO:0005200|structural constituent of cytoskeleton;GO:0005515|protein binding;GO:0019900|kinase binding;GO:0042802|identical protein binding;","K05640","GFAP; glial fibrillary acidic protein"]
["ENSRNOG00000013605",12,0.771965258,4,0.258247439,2.989246524,1.579781881,0.041543284,0.019677107,"up","yes","AC120568.1","protein_coding","chr4:104566211-104574118:-","gi|672018429|ref|XP_008773992.1|",1655,0,"PREDICTED: SH2 domain-containing protein 6 [Rattus norvegicus]","gi|672018428|ref|XM_008775770.1|",709,0,"PREDICTED: Rattus norvegicus hypothetical protein LOC691161 (LOC691161), mRNA","Q9D413",423,{"v":2e-144,"d":"2.00E-144"},"SH2 domain-containing protein 6",".",".",".",".","pfam00017","SH2","SH2 domain.",".",".",".",".","."]
["ENSRNOG00000029147",12,0.771965258,4,0.258247439,2.989246524,1.579781881,0.041543284,0.019677107,"up","yes","Rbm11","protein_coding","chr11:14234890-14244090:+","gi|564375907|ref|XP_006248056.1|",1008,{"v":1E-127,"d":"1.00E-127"},"PREDICTED: splicing regulator RBM11 isoform X1 [Rattus norvegicus]","gi|672070391|ref|XM_006247994.2|",1683,0,"PREDICTED: Rattus norvegicus RNA binding motif protein 11 (Rbm11), transcript variant X1, mRNA","Q80YT9",347,{"v":1e-111,"d":"1.00E-111"},"Splicing regulator RBM11",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0000381|regulation of alternative mRNA splicing, via spliceosome;GO:0034599|cellular response to oxidative stress;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0016607|nuclear speck;","GO:0003727|single-stranded RNA binding;GO:0008266|poly(U) RNA binding;GO:0042803|protein homodimerization activity;","K25005","RBM11; splicing regulator RBM11"]
["ENSRNOG00000039568",12,0.771965258,4,0.258247439,2.989246524,1.579781881,0.041543284,0.019677107,"up","yes","Mgat4e","protein_coding","chr13:45982164-46001050:-","gi|564315792|ref|XP_006221537.1|",2335,0,"PREDICTED: alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein [Rattus norvegicus]","gi|672027117|ref|XM_008762290.1|",1556,0,"PREDICTED: Rattus norvegicus similar to 40S ribosomal protein S7 (S8) (RGD1308112), transcript variant X3, mRNA","A6H684",615,0,"Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4E",".",".",".",".","pfam04666","Glyco_transf_54","N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region. The complex-type of oligosaccharides are synthesized through elongation by glycosyltransferases after trimming of the precursor oligosaccharides transferred to proteins in the endoplasmic reticulum. N-Acetylglucosaminyltransferases (GnTs) take part in the formation of branches in the biosynthesis of complex-type sugar chains. In vertebrates, six GnTs, designated as GnT-I to -VI, which catalyse the transfer of GlcNAc to the core mannose residues of Asn-linked sugar chains, have been identified. GnT-IV (EC:2.4.1.145) catalyses the transfer of GlcNAc from UDP-GlcNAc to the GlcNAc1-2Man1-3 arm of core oligosaccharide [Gn2(22)core oligosaccharide] and forms GlcNAc1-4(GlcNAc1-2)Man1-3 structure on the core oligosaccharide (Gn3(2,4,2)core oligosaccharide). In some members the conserved region occupies all but the very for N-terminal, where there is a signal sequence on all members. For other members the conserved region does not occupy the entire protein but is still to the N-terminus of the protein.","GO:0006487|protein N-linked glycosylation;","GO:0016021|integral component of membrane;","GO:0008375|acetylglucosaminyltransferase activity;",".","."]
["ENSRNOG00000052061",12,0.771965258,4,0.258247439,2.989246524,1.579781881,0.041543284,0.019677107,"up","yes","Ppef2","protein_coding","chr14:15797435-15831491:+","gi|157821531|ref|NP_001100680.1|",3933,0,"serine/threonine-protein phosphatase with EF-hands 2 [Rattus norvegicus]","gi|157821530|ref|NM_001107210.1|",3095,0,"Rattus norvegicus protein phosphatase with EF-hand domain 2 (Ppef2), mRNA","O35385",1457,0,"Serine/threonine-protein phosphatase with EF-hands 2","SPBC3F6.01c_2",126,{"v":2e-30,"d":"2.00E-30"},"COG0639","pfam00149","Metallophos","Calcineurin-like phosphoesterase. This family includes a diverse range of phosphoesterases, including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD or yeast MRE11. The most conserved regions in this superfamily centre around the metal chelating residues.","GO:0006470|protein dephosphorylation;GO:0010801|negative regulation of peptidyl-threonine phosphorylation;GO:0043409|negative regulation of MAPK cascade;GO:0050906|detection of stimulus involved in sensory perception;","GO:0005634|nucleus;GO:0005829|cytosol;","GO:0004722|protein serine/threonine phosphatase activity;GO:0005506|iron ion binding;GO:0005509|calcium ion binding;GO:0030145|manganese ion binding;GO:0030544|Hsp70 protein binding;GO:0031435|mitogen-activated protein kinase kinase kinase binding;GO:0051879|Hsp90 protein binding;","K13807","PPEF, PPP7C; serine/threonine-protein phosphatase with EF-hands [EC:3.1.3.16]"]
["ENSRNOG00000054461",12,0.771965258,4,0.258247439,2.989246524,1.579781881,0.041543284,0.019677107,"up","yes","RNaseP_nuc","ribozyme","chr3:37398482-37398789:+","gi|426376198|ref|XP_004054894.1|",100,1E-8,"PREDICTED: uncharacterized protein LOC101140100 [Gorilla gorilla gorilla]","gi|157742930|gb|BC116202.1|",158,{"v":1e-75,"d":"1.00E-75"},"Mus musculus cDNA clone IMAGE:40090112",".",".",".",".",".",".",".",".","pfam04817","Umbravirus_LDM","Umbravirus long distance movement (LDM) family. The long distance movement protein of Umbraviruses mediates the movement of viral RNA through the phloem of infected plants.",".",".",".",".","."]
["ENSRNOG00000063651",12,0.771965258,4,0.258247439,2.989246524,1.579781881,0.041543284,0.019677107,"up","yes","ENSRNOG00000063651","lncRNA","chr20:17943254-18024429:-","gi|148677466|gb|EDL09413.1|",185,{"v":8E-14,"d":"8.00E-14"},"mCG147326 [Mus musculus]","gi|672031653|ref|XR_599394.1|",583,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102548544 (LOC102548544), ncRNA",".",".",".",".",".",".",".",".","pfam04632","FUSC","Fusaric acid resistance protein family. This family includes a conserved region found in two proteins associated with fusaric acid resistance, from Burkholderia cepacia and Klebsiella oxytoca. These proteins are likely to be membrane transporter proteins.",".",".",".",".","."]
["ENSRNOG00000064644",12,0.771965258,4,0.258247439,2.989246524,1.579781881,0.041543284,0.019677107,"up","yes","ENSRNOG00000064644","protein_coding","chr2:102238973-102239962:+","gi|820974507|ref|XP_012360476.1|",168,{"v":6e-13,"d":"6.00E-13"},"PREDICTED: CCR4-NOT transcription complex subunit 8 isoform X2 [Nomascus leucogenys]",".",".",".",".","Q9UFF9",65.9,{"v":2e-13,"d":"2.00E-13"},"CCR4-NOT transcription complex subunit 8",".",".",".",".","pfam04857","CAF1","CAF1 family ribonuclease. The major pathways of mRNA turnover in eukaryotes initiate with shortening of the polyA tail. CAF1 encodes a critical component of the major cytoplasmic deadenylase in yeast. Both Caf1p is required for normal mRNA deadenylation in vivo and localizes to the cytoplasm. Caf1p copurifies with a Ccr4p-dependent polyA-specific exonuclease activity. Some members of this family include and inserted RNA binding domain pfam01424. This family of proteins is related to other exonucleases pfam00929 (Bateman A pers. obs.). The crystal structure of Saccharomyces cerevisiae Pop2 has been resolved at 2.3 Angstrom#resolution.",".",".",".",".","."]
["ENSRNOG00000005936",15,0.964956573,6,0.387371158,2.49103877,1.316747476,0.046833114,0.021968695,"up","yes","Foxm1","protein_coding","chr4:161638816-161650684:+","gi|564349102|ref|XP_006237479.1|",3437,0,"PREDICTED: forkhead box protein M1 isoform X2 [Rattus norvegicus]","gi|672051236|ref|XM_006237421.2|",3349,0,"PREDICTED: Rattus norvegicus forkhead box M1 (Foxm1), transcript variant X6, mRNA","P97691",1318,0,"Forkhead box protein M1","YCR065w",87.8,{"v":8e-17,"d":"8.00E-17"},"COG5025","pfam00250","Fork_head","Fork head domain.","GO:0000086|G2/M transition of mitotic cell cycle;GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001570|vasculogenesis;GO:0001889|liver development;GO:0006281|DNA repair;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;GO:0008284|positive regulation of cell proliferation;GO:0032873|negative regulation of stress-activated MAPK cascade;GO:0034698|response to gonadotropin;GO:0042127|regulation of cell proliferation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046578|regulation of Ras protein signal transduction;GO:0051591|response to cAMP;GO:0051726|regulation of cell cycle;GO:0090344|negative regulation of cell aging;GO:2000377|regulation of reactive oxygen species metabolic process;GO:2000781|positive regulation of double-strand break repair;","GO:0005575|cellular_component;GO:0005634|nucleus;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0019901|protein kinase binding;GO:0043565|sequence-specific DNA binding;","K09406","FOXM; forkhead box protein M"]
["ENSRNOG00000064890",15,0.964956573,6,0.387371158,2.49103877,1.316747476,0.046833114,0.021968695,"up","yes","ENSRNOG00000064890","pseudogene","chr14:46603666-46604536:-","gi|612002131|ref|XP_007485990.1|",556,{"v":2E-66,"d":"2.00E-66"},"PREDICTED: transformer-2 protein homolog beta-like isoform X1 [Monodelphis domestica]","gi|672076320|ref|XR_359545.2|",703,0,"PREDICTED: Rattus norvegicus similar to splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) (LOC685935), transcript variant X2, misc_RNA","P62997",213,{"v":4e-66,"d":"4.00E-66"},"Transformer-2 protein homolog beta",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.",".",".",".",".","."]
["ENSRNOG00000069067",15,0.964956573,6,0.387371158,2.49103877,1.316747476,0.046833114,0.021968695,"up","yes","ENSRNOG00000069067","protein_coding","chr1:208547234-208561558:+","gi|223461200|gb|AAI41229.1|",672,{"v":1e-86,"d":"1.00E-86"},"Gene model 97, (NCBI) [Mus musculus]","gi|223461199|gb|BC141228.1|",222,{"v":6e-111,"d":"6.00E-111"},"Mus musculus gene model 97, (NCBI), mRNA (cDNA clone MGC:176189 IMAGE:9055840), complete cds","Q925U0",55.5,1E-8,"Oocyte-secreted protein 1",".",".",".",".","pfam00100","Zona_pellucida","Zona pellucida-like domain.",".",".",".",".","."]
["ENSRNOG00000017974",21,1.350939202,10,0.645618597,2.092472567,1.065208709,0.046870354,0.021968695,"up","yes","Gprin1","protein_coding","chr17:9863571-9876915:+","gi|564390601|ref|XP_344572.6|",4083,0,"PREDICTED: LOW QUALITY PROTEIN: G protein-regulated inducer of neurite outgrowth 1 isoform X2 [Rattus norvegicus]","gi|672081205|ref|XM_344571.7|",3805,0,"PREDICTED: Rattus norvegicus G protein-regulated inducer of neurite outgrowth 1 (Gprin1), transcript variant X2, mRNA","Q3UNH4",1222,0,"G protein-regulated inducer of neurite outgrowth 1",".",".",".",".","pfam15235","GRIN_C","G protein-regulated inducer of neurite outgrowth C-terminus. This represents the C-terminus of the G protein-regulated inducer of neurite outgrowth proteins.","GO:0031175|neuron projection development;","GO:0005886|plasma membrane;","GO:0051219|phosphoprotein binding;",".","."]
["ENSRNOG00000049849",21,1.350939202,10,0.645618597,2.092472567,1.065208709,0.046870354,0.021968695,"up","yes","ENSRNOG00000049849","protein_coding","chrX:100384225-100414938:+","gi|148691944|gb|EDL23891.1|",1665,0,"cDNA sequence BC031748, partial [Mus musculus]","gi|274320576|ref|NM_146261.2|",2018,0,"Mus musculus family with sequence similarity 199, X-linked (Fam199x), mRNA",".",".",".",".",".",".",".",".","pfam06278","DUF1032","Protein of unknown function (DUF1032). This family consists of several conserved eukaryotic proteins of unknown function.",".",".",".",".","."]
["ENSRNOG00000058474",21,1.350939202,10,0.645618597,2.092472567,1.065208709,0.046870354,0.021968695,"up","yes","AABR07015941.1","protein_coding","chr14:81556417-81557011:-","gi|591350391|ref|XP_007069732.1|",300,{"v":3e-33,"d":"3.00E-33"},"PREDICTED: 40S ribosomal protein S19-like [Chelonia mydas]","gi|672064502|ref|XM_003750647.3|",155,{"v":5E-74,"d":"5.00E-74"},"PREDICTED: Rattus norvegicus 40S ribosomal protein S19-like (LOC100910336), transcript variant X1, mRNA","P17074",118,{"v":2e-33,"d":"2.00E-33"},"40S ribosomal protein S19","SPBC649.02",80.9,{"v":1e-19,"d":"1.00E-19"},"COG2238","pfam01090","Ribosomal_S19e","Ribosomal protein S19e.",".",".",".",".","."]
["ENSRNOG00000063087",21,1.350939202,10,0.645618597,2.092472567,1.065208709,0.046870354,0.021968695,"up","yes","ENSRNOG00000063087","protein_coding","chr3:143138332-143139527:+","gi|344250492|gb|EGW06596.1|",918,{"v":5e-118,"d":"5.00E-118"},"Elongation factor 1-alpha 1 [Cricetulus griseus]","gi|672047760|ref|XR_591795.1|",774,0,"PREDICTED: Rattus norvegicus elongation factor 1-alpha 1 pseudogene (LOC103691939), misc_RNA","P62630",262,{"v":1e-82,"d":"1.00E-82"},"Elongation factor 1-alpha 1","SPBC839.15c",230,{"v":4e-71,"d":"4.00E-71"},"COG5256","pfam03143","GTP_EFTU_D3","Elongation factor Tu C-terminal domain. Elongation factor Tu consists of three structural domains, this is the third domain. This domain adopts a beta barrel structure. This the third domain is involved in binding to both charged tRNA and binding to EF-Ts pfam00889.",".",".",".",".","."]
["ENSRNOG00000066111",21,1.350939202,10,0.645618597,2.092472567,1.065208709,0.046870354,0.021968695,"up","yes","Kcns2","protein_coding","chr7:66022352-66028422:+","gi|674047392|ref|XP_008829765.1|",2561,0,"PREDICTED: potassium voltage-gated channel subfamily S member 2 [Nannospalax galili]","gi|242397613|gb|AC119540.6|",4980,0,"Rattus norvegicus CH230-490H7 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q9ER26",955,0,"Potassium voltage-gated channel subfamily S member 2","MA2034",90.1,{"v":3e-18,"d":"3.00E-18"},"COG1226","pfam02214","BTB_2","BTB/POZ domain. In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.",".",".",".",".","."]
["ENSRNOG00000012022",10,0.643304382,3,0.193685579,3.321385027,1.731784975,0.046979557,0.021969606,"up","yes","RGD1562914","protein_coding","chr8:51607763-51648628:-","gi|148693832|gb|EDL25779.1|",1277,{"v":3e-172,"d":"3.00E-172"},"mCG4182, partial [Mus musculus]","gi|672022802|ref|XM_008776709.1|",1058,0,"PREDICTED: Rattus norvegicus RGD1562914 (RGD1562914), mRNA",".",".",".",".",".",".",".",".","pfam04078","Rcd1","Cell differentiation family, Rcd1-like. Two of the members in this family have been characterized as being involved in regulation of Ste11 regulated sex genes. Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation.",".",".",".",".","."]
["ENSRNOG00000013222",10,0.643304382,3,0.193685579,3.321385027,1.731784975,0.046979557,0.021969606,"up","yes","Cd207","protein_coding","chr4:116155212-116161518:-","gi|392340083|ref|XP_002726471.2|",1794,0,"PREDICTED: C-type lectin domain family 4 member K [Rattus norvegicus]","gi|672018474|ref|XM_002726425.4|",1469,0,"PREDICTED: Rattus norvegicus CD207 molecule, langerin (Cd207), mRNA","Q8VBX4",613,0,"C-type lectin domain family 4 member K",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0051607|defense response to virus;","GO:0016021|integral component of membrane;","GO:0030246|carbohydrate binding;","K06561","CD207; CD207 antigen"]
["ENSRNOG00000021800",10,0.643304382,3,0.193685579,3.321385027,1.731784975,0.046979557,0.021969606,"up","yes","Zfp541","protein_coding","chr1:76750236-76786567:+","gi|392337463|ref|XP_003753266.1|",6015,0,"PREDICTED: zinc finger protein 541 [Rattus norvegicus]","gi|672035365|ref|XM_008759028.1|",6234,0,"PREDICTED: Rattus norvegicus zinc finger protein 541 (Zfp541), transcript variant X6, mRNA","Q0GGX2",1469,0,"Zinc finger protein 541",".",".",".",".","pfam01448","ELM2","ELM2 domain. The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in a member from Arabidopsis thaliana. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0016575|histone deacetylation;GO:0045892|negative regulation of transcription, DNA-templated;","GO:0000118|histone deacetylase complex;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0003714|transcription corepressor activity;",".","."]
["ENSRNOG00000039832",10,0.643304382,3,0.193685579,3.321385027,1.731784975,0.046979557,0.021969606,"up","yes","Gpr12","protein_coding","chr12:8522953-8527973:+","gi|13540628|ref|NP_110458.1|",1645,0,"G-protein coupled receptor 12 [Rattus norvegicus]","gi|91982768|ref|NM_001010941.2|",1594,0,"Mus musculus G-protein coupled receptor 12 (Gpr12), transcript variant 1, mRNA","P30951",638,0,"G-protein coupled receptor 12",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0006874|cellular calcium ion homeostasis;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0019222|regulation of metabolic process;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0031210|phosphatidylcholine binding;","K04315","GPR12; G protein-coupled receptor 12"]
["ENSRNOG00000052109",10,0.643304382,3,0.193685579,3.321385027,1.731784975,0.046979557,0.021969606,"up","yes","AABR07043389.1","lncRNA","chr19:13741284-13768111:+","gi|564394342|ref|XP_006255099.1|",172,{"v":5e-13,"d":"5.00E-13"},"PREDICTED: uncharacterized protein LOC102547811 isoform X2 [Rattus norvegicus]","gi|672084606|ref|XM_006255351.2|",335,{"v":6e-174,"d":"6.00E-174"},"PREDICTED: Rattus norvegicus uncharacterized LOC102552540 (LOC102552540), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam04647","AgrB","Accessory gene regulator B. The arg locus consists of two transcripts: RNAII and RNAIII. RNAII encodes four genes (agrA, B, C, and D) whose gene products assemble a quorum sensing system. AgrB and AgrD are essential for the production of the autoinducing peptide which functions as a signal for quorum sensing. AgrB is a transmembrane protein.",".",".",".",".","."]
["ENSRNOG00000052948",10,0.643304382,3,0.193685579,3.321385027,1.731784975,0.046979557,0.021969606,"up","yes","AABR07049134.4","lncRNA","chr5:103365187-103372237:-","gi|564305767|ref|XP_006225482.1|",1011,{"v":2e-126,"d":"2.00E-126"},"PREDICTED: uncharacterized protein LOC102556773 [Rattus norvegicus]","gi|71057062|emb|CR937053.2|",1305,0,"Rattus norvegicus chromosome 1 BAC CH230-476F3, complete sequence",".",".",".",".",".",".",".",".","pfam11864","DUF3384","Domain of unknown function (DUF3384). This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is typically between 422 to 486 amino acids in length. This domain is found associated with pfam02145.",".",".",".",".","."]
["ENSRNOG00000059833",10,0.643304382,3,0.193685579,3.321385027,1.731784975,0.046979557,0.021969606,"up","yes","AABR07073270.1","snoRNA","chr7:834295-834439:-",".",".",".",".","gi|908663415|tpe|LN872606.1|",95,{"v":5e-41,"d":"5.00E-41"},"TPA: Mus musculus SNORA79 (ACA65) gene for small nucleolar RNA SNORA79 (ACA65)",".",".",".",".",".",".",".",".","pfam01081","Aldolase","KDPG and KHG aldolase. This family includes the following members: 4-hydroxy-2-oxoglutarate aldolase (KHG-aldolase) Phospho-2-dehydro-3-deoxygluconate aldolase (KDPG-aldolase)",".",".",".",".","."]
["ENSRNOG00000062465",10,0.643304382,3,0.193685579,3.321385027,1.731784975,0.046979557,0.021969606,"up","yes","ENSRNOG00000062465","protein_coding","chr14:97517407-97518328:+","gi|589958246|ref|XP_006991719.1|",774,{"v":9e-101,"d":"9.00E-101"},"PREDICTED: deoxycytidine kinase [Peromyscus maniculatus bairdii]","gi|298900663|emb|FQ212366.1|",320,{"v":2E-165,"d":"2.00E-165"},"Rattus norvegicus TL0AAA57YJ12 mRNA sequence","P43346",295,{"v":2E-99,"d":"2.00E-99"},"Deoxycytidine kinase",".",".",".",".","pfam01712","dNK","Deoxynucleoside kinase. This family consists of various deoxynucleoside kinases cytidine EC:2.7.1.74, guanosine EC:2.7.1.113, adenosine EC:2.7.1.76 and thymidine kinase EC:2.7.1.21 (which also phosphorylates deoxyuridine and deoxycytosine.) These enzymes catalyse the production of deoxynucleotide 5'-monophosphate from a deoxynucleoside. Using ATP and yielding ADP in the process.",".",".",".",".","."]
["ENSRNOG00000063514",10,0.643304382,3,0.193685579,3.321385027,1.731784975,0.046979557,0.021969606,"up","yes","ENSRNOG00000063514","lncRNA","chr13:43945144-43946212:+",".",".",".",".","gi|672073641|ref|XM_008769427.1|",1069,0,"PREDICTED: Rattus norvegicus contactin 2 (axonal) (Cntn2), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam10600","PDZ_assoc","PDZ-associated domain of NMDA receptors. This domain is found in higher eukaryotes between the second and third PDZ domains, pfam00595, of glutamate receptor like proteins. Its exact function is not known.",".",".",".",".","."]
["ENSRNOG00000066037",10,0.643304382,3,0.193685579,3.321385027,1.731784975,0.046979557,0.021969606,"up","yes","ENSRNOG00000066037","lncRNA","chr17:73347582-73350610:+",".",".",".",".","gi|49406050|gb|AC084310.16|",78,{"v":5e-31,"d":"5.00E-31"},"Mus musculus chromosome 1, clone RP23-10C10, complete sequence",".",".",".",".",".",".",".",".","pfam00710","Asparaginase","Asparaginase.",".",".",".",".","."]
["ENSRNOG00000066292",10,0.643304382,3,0.193685579,3.321385027,1.731784975,0.046979557,0.021969606,"up","yes","ENSRNOG00000066292","lncRNA","chr19:48159387-48161711:-",".",".",".",".","gi|3068810|gb|AF059580.1|",126,{"v":2e-57,"d":"2.00E-57"},"Murine genomic DNA; partially digested Sau3A fragment, cloned into cosmid vector pEMBLcos2, complete sequence",".",".",".",".",".",".",".",".","pfam00840","Glyco_hydro_7","Glycosyl hydrolase family 7.",".",".",".",".","."]
["ENSRNOG00000002224",6,0.385982629,1,0.06456186,5.978493048,2.579781881,0.047823264,0.02230025,"up","yes","Yipf7","protein_coding","chr14:38571066-38599055:+","gi|564383867|ref|XP_006251101.1|",1354,0,"PREDICTED: protein YIPF7 isoform X2 [Rattus norvegicus]","gi|298901146|emb|FQ215959.1|",1182,0,"Rattus norvegicus TL0ACA45YK06 mRNA sequence","Q9JIM5",475,{"v":4E-167,"d":"4.00E-167"},"Protein YIPF7","SPCC61.04c",166,{"v":2e-47,"d":"2.00E-47"},"COG5080","pfam04893","Yip1","Yip1 domain. The Yip1 integral membrane domain contains four transmembrane alpha helices. The domain is characterized by the motifs DLYGP and GY. The Yip1 protein is a golgi protein involved in vesicular transport that interacts with GTPases.","GO:0006888|ER to Golgi vesicle-mediated transport;GO:0048280|vesicle fusion with Golgi apparatus;","GO:0005802|trans-Golgi network;GO:0016021|integral component of membrane;",".","K20363","YIPF5_7, YIP1; protein YIPF5/7"]
["ENSRNOG00000002593",6,0.385982629,1,0.06456186,5.978493048,2.579781881,0.047823264,0.02230025,"up","yes","Esrrg","protein_coding","chr13:99564669-99783397:+","gi|6753774|ref|NP_036065.1|",2372,0,"estrogen-related receptor gamma isoform1 [Mus musculus]","gi|672075170|ref|XM_006250443.2|",3074,0,"PREDICTED: Rattus norvegicus estrogen-related receptor gamma (Esrrg), transcript variant X1, mRNA","P62510",917,0,"Estrogen-related receptor gamma",".",".",".",".","pfam00105","zf-C4","Zinc finger, C4 type (two domains). In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.","GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0043401|steroid hormone mediated signaling pathway;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048384|retinoic acid receptor signaling pathway;GO:0120162|positive regulation of cold-induced thermogenesis;","GO:0005634|nucleus;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003707|steroid hormone receptor activity;GO:0004879|nuclear receptor activity;GO:0005496|steroid binding;GO:0008270|zinc ion binding;GO:0042802|identical protein binding;GO:0050682|AF-2 domain binding;GO:1990837|sequence-specific double-stranded DNA binding;","K08554","NR3B3, ESRRG; estrogen-related receptor gamma"]
["ENSRNOG00000003469",6,0.385982629,1,0.06456186,5.978493048,2.579781881,0.047823264,0.02230025,"up","yes","MAST1","protein_coding","chr19:23207991-23244235:+","gi|30842796|ref|NP_851603.1|",7191,0,"microtubule-associated serine/threonine-protein kinase 1 [Rattus norvegicus]","gi|30842795|ref|NM_181089.1|",4654,0,"Rattus norvegicus microtubule associated serine/threonine kinase 1 (MAST1), mRNA","Q810W7",2774,0,"Microtubule-associated serine/threonine-protein kinase 1",".",".",".",".","pfam08926","DUF1908","Domain of unknown function (DUF1908). This domain is found in a set of hypothetical/structural eukaryotic proteins.","GO:0006468|protein phosphorylation;GO:0007010|cytoskeleton organization;GO:0007420|brain development;GO:0018105|peptidyl-serine phosphorylation;GO:0035556|intracellular signal transduction;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0043005|neuron projection;GO:0043025|neuronal cell body;","GO:0000287|magnesium ion binding;GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;GO:0008017|microtubule binding;","K08789","MAST; microtubule-associated serine/threonine kinase [EC:2.7.11.1]"]
["ENSRNOG00000011374",6,0.385982629,1,0.06456186,5.978493048,2.579781881,0.047823264,0.02230025,"up","yes","Catsper3","protein_coding","chr17:8815561-8840864:-","gi|564390364|ref|XP_006253634.1|",1795,0,"PREDICTED: cation channel sperm-associated protein 3 isoform X1 [Rattus norvegicus]","gi|672080876|ref|XM_006253572.2|",1340,0,"PREDICTED: Rattus norvegicus cation channel, sperm associated 3 (Catsper3), transcript variant X1, mRNA","Q80W99",566,0,"Cation channel sperm-associated protein 3",".",".",".",".","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0006814|sodium ion transport;GO:0030317|flagellated sperm motility;GO:0048240|sperm capacitation;GO:0070588|calcium ion transmembrane transport;","GO:0001669|acrosomal vesicle;GO:0005783|endoplasmic reticulum;GO:0036128|CatSper complex;","GO:0005245|voltage-gated calcium channel activity;","K16891","CATSPER3; cation channel sperm-associated protein 3"]
["ENSRNOG00000012720",6,0.385982629,1,0.06456186,5.978493048,2.579781881,0.047823264,0.02230025,"up","yes","Irx4","protein_coding","chr1:30030561-30039549:-","gi|157823705|ref|NP_001100800.1|",2133,0,"iroquois-class homeodomain protein IRX-4 [Rattus norvegicus]","gi|157823704|ref|NM_001107330.1|",2526,0,"Rattus norvegicus iroquois homeobox 4 (Irx4), mRNA","Q9QY61",784,0,"Iroquois-class homeodomain protein IRX-4",".",".",".",".","pfam05920","Homeobox_KN","Homeobox KN domain. This is a homeobox transcription factor KN domain conserved from fungi to human and plants.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0007507|heart development;GO:0030182|neuron differentiation;GO:0048468|cell development;GO:0048561|establishment of animal organ orientation;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;","K24889","IRX; iroquois-class homeodomain protein IRX"]
["ENSRNOG00000013573",6,0.385982629,1,0.06456186,5.978493048,2.579781881,0.047823264,0.02230025,"up","yes","Atp6v1b1","protein_coding","chr4:116223799-116242475:+","gi|164607173|ref|NP_001101337.2|",2756,0,"V-type proton ATPase subunit B, kidney isoform [Rattus norvegicus]","gi|164607172|ref|NM_001107867.2|",2447,0,"Rattus norvegicus ATPase H+ transporting V1 subunit B1 (Atp6v1b1), mRNA","P15313",1010,0,"V-type proton ATPase subunit B, kidney isoform","SPAC637.05c",785,0,"COG1156","pfam00006","ATP-synt_ab","ATP synthase alpha/beta family, nucleotide-binding domain. This family includes the ATP synthase alpha and beta subunits, the ATP synthase associated with flagella and the termination factor Rho.","GO:0001503|ossification;GO:0003091|renal water homeostasis;GO:0003096|renal sodium ion transport;GO:0006693|prostaglandin metabolic process;GO:0006885|regulation of pH;GO:0007588|excretion;GO:0007605|sensory perception of sound;GO:0008150|biological_process;GO:0010468|regulation of gene expression;GO:0030534|adult behavior;GO:0035812|renal sodium excretion;GO:0042048|olfactory behavior;GO:0042472|inner ear morphogenesis;GO:0045851|pH reduction;GO:0046034|ATP metabolic process;GO:0055064|chloride ion homeostasis;GO:0055074|calcium ion homeostasis;GO:0055075|potassium ion homeostasis;GO:0070072|vacuolar proton-transporting V-type ATPase complex assembly;GO:0097401|synaptic vesicle lumen acidification;GO:1902600|proton transmembrane transport;","GO:0000221|vacuolar proton-transporting V-type ATPase, V1 domain;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005902|microvillus;GO:0008021|synaptic vesicle;GO:0016020|membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0016328|lateral plasma membrane;GO:0016471|vacuolar proton-transporting V-type ATPase complex;GO:0098850|extrinsic component of synaptic vesicle membrane;","GO:0005524|ATP binding;GO:0015078|proton transmembrane transporter activity;GO:0044877|protein-containing complex binding;","K02147","ATPeV1B, ATP6B; V-type H+-transporting ATPase subunit B"]
["ENSRNOG00000020045",6,0.385982629,1,0.06456186,5.978493048,2.579781881,0.047823264,0.02230025,"up","yes","Drgx","protein_coding","chr16:7854849-7900600:+","gi|568986424|ref|XP_006518472.1|",1364,{"v":2E-179,"d":"2.00E-179"},"PREDICTED: dorsal root ganglia homeobox protein isoform X2 [Mus musculus]","gi|21955175|ref|NM_145767.1|",2374,0,"Rattus norvegicus dorsal root ganglia homeobox (Drgx), mRNA","Q62798",491,{"v":4E-167,"d":"4.00E-167"},"Dorsal root ganglia homeobox protein","ECU03g1170",50.1,8e-06,"COG5576","pfam00046","Homeobox","Homeobox domain.","GO:0001764|neuron migration;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007399|nervous system development;GO:0007409|axonogenesis;GO:0007411|axon guidance;GO:0009593|detection of chemical stimulus;GO:0016048|detection of temperature stimulus;GO:0021516|dorsal spinal cord development;GO:0021559|trigeminal nerve development;GO:0030182|neuron differentiation;GO:0050954|sensory perception of mechanical stimulus;","GO:0005634|nucleus;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K24895","DRGX, PRRXL1; dorsal root ganglia homeobox protein"]
["ENSRNOG00000022476",6,0.385982629,1,0.06456186,5.978493048,2.579781881,0.047823264,0.02230025,"up","yes","ENSRNOG00000022476","protein_coding","chrX:77453357-77469158:-","gi|254587982|ref|NP_001157015.1|",3708,0,"spermidine/spermine N(1)-acetyltransferase-like protein 1 [Rattus norvegicus]","gi|672087911|ref|XM_006257190.2|",2407,0,"PREDICTED: Rattus norvegicus spermidine/spermine N1-acetyl transferase-like 1 (Satl1), transcript variant X1, mRNA","Q9D5N8",978,0,"Spermidine/spermine N(1)-acetyltransferase-like protein 1",".",".",".",".","pfam03157","Glutenin_hmw","High molecular weight glutenin subunit. Members of this family include high molecular weight subunits of glutenin. This group of gluten proteins is thought to be largely responsible for the elastic properties of gluten, and hence, doughs. Indeed, glutenin high molecular weight subunits are classified as elastomeric proteins, because the glutenin network can withstand significant deformations without breaking, and return to the original conformation when the stress is removed. Elastomeric proteins differ considerably in amino acid sequence, but they are all polymers whose subunits consist of elastomeric domains, composed of repeated motifs, and non-elastic domains that mediate cross-linking between the subunits. The elastomeric domain motifs are all rich in glycine residues in addition to other hydrophobic residues. High molecular weight glutenin subunits have an extensive central elastomeric domain, flanked by two terminal non-elastic domains that form disulphide cross-links. The central elastomeric domain is characterized by the following three repeated motifs: PGQGQQ, GYYPTS[P/L]QQ, GQQ. It possesses overlapping beta-turns within and between the repeated motifs, and assumes a regular helical secondary structure with a diameter of approx. 1.9 nm and a pitch of approx. 1.5 nm.",".",".","GO:0008080|N-acetyltransferase activity;",".","."]
["ENSRNOG00000029859",6,0.385982629,1,0.06456186,5.978493048,2.579781881,0.047823264,0.02230025,"up","yes","AABR07021384.1","protein_coding","chr13:63894996-63895466:-","gi|355750095|gb|EHH54433.1|",630,{"v":4e-81,"d":"4.00E-81"},"hypothetical protein EGM_15272 [Macaca fascicularis]","gi|298916685|emb|FQ210401.1|",432,0,"Rattus norvegicus TL0ABA29YG01 mRNA sequence","P62752",244,{"v":2e-81,"d":"2.00E-81"},"60S ribosomal protein L23a","YOL127w",162,{"v":3e-50,"d":"3.00E-50"},"COG0089","pfam03939","Ribosomal_L23eN","Ribosomal protein L23, N-terminal domain. The N-terminal domain appears to be specific to the eukaryotic ribosomal proteins L25, L23, and L23a.","GO:0006412|translation;",".",".",".","."]
["ENSRNOG00000032461",6,0.385982629,1,0.06456186,5.978493048,2.579781881,0.047823264,0.02230025,"up","yes","Bin2a","protein_coding","chr8:25248570-25287173:-","gi|564362841|ref|XP_006242799.1|",3402,0,"PREDICTED: beta-galactosidase-like protein isoform X1 [Rattus norvegicus]","gi|57222331|ref|NM_001009524.1|",2584,0,"Rattus norvegicus beta-galactosidase-like protein (Bin2a), mRNA","Q8IW92",597,0,"Beta-galactosidase-1-like protein 2","XF0840",342,{"v":5e-105,"d":"5.00E-105"},"COG1874","pfam01301","Glyco_hydro_35","Glycosyl hydrolases family 35.","GO:0005975|carbohydrate metabolic process;","GO:0005773|vacuole;","GO:0004565|beta-galactosidase activity;",".","."]
["ENSRNOG00000035618",6,0.385982629,1,0.06456186,5.978493048,2.579781881,0.047823264,0.02230025,"up","yes","Mir345","miRNA","chr6:127754027-127754122:+",".",".",".",".","gi|354794315|gb|JN958816.1|",96,{"v":8e-42,"d":"8.00E-42"},"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Slc25a29:tm1a(KOMP)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam15402","Spc7_N","N-terminus of kinetochore NMS complex subunit Spc7.","GO:0007605|sensory perception of sound;GO:0009617|response to bacterium;GO:0060291|long-term synaptic potentiation;GO:0071222|cellular response to lipopolysaccharide;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0016442|RISC complex;",".","K17375","MIR345; microRNA 345"]
["ENSRNOG00000046438",6,0.385982629,1,0.06456186,5.978493048,2.579781881,0.047823264,0.02230025,"up","yes","AABR07000583.1","protein_coding","chr1:17691637-17692974:-","gi|564391750|ref|XP_006254139.1|",1144,{"v":1e-152,"d":"1.00E-152"},"PREDICTED: ral guanine nucleotide dissociation stimulator-like isoform X1 [Rattus norvegicus]","gi|672082214|ref|XM_006254078.2|",935,0,"PREDICTED: Rattus norvegicus ral guanine nucleotide dissociation stimulator-like (LOC102553208), transcript variant X2, mRNA","Q03386",105,{"v":5e-23,"d":"5.00E-23"},"Ral guanine nucleotide dissociation stimulator",".",".",".",".","pfam00618","RasGEF_N","RasGEF N-terminal motif. A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this motif/domain N-terminal to the RasGef (Cdc25-like) domain.",".",".",".",".","."]
["ENSRNOG00000047085",6,0.385982629,1,0.06456186,5.978493048,2.579781881,0.047823264,0.02230025,"up","yes","Lrrtm2","protein_coding","chr18:26817816-26822864:-","gi|28972213|dbj|BAC65560.1|",2739,0,"mKIAA0416 protein [Mus musculus]","gi|157822902|ref|NM_001109469.1|",4715,0,"Rattus norvegicus leucine rich repeat transmembrane neuronal 2 (Lrrtm2), mRNA","D4A7P2",1036,0,"Leucine-rich repeat transmembrane neuronal protein 2","SPy1798",101,{"v":2e-20,"d":"2.00E-20"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0002091|negative regulation of receptor internalization;GO:0050808|synapse organization;GO:0051965|positive regulation of synapse assembly;GO:0060291|long-term synaptic potentiation;GO:0099151|regulation of postsynaptic density assembly;","GO:0005615|extracellular space;GO:0060076|excitatory synapse;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098686|hippocampal mossy fiber to CA3 synapse;GO:0098978|glutamatergic synapse;GO:0098982|GABA-ergic synapse;GO:0099060|integral component of postsynaptic specialization membrane;GO:0099061|integral component of postsynaptic density membrane;","GO:0042043|neurexin family protein binding;","K16665","LRRTM1_2; leucine-rich repeat transmembrane neuronal protein 1/2"]
["ENSRNOG00000050690",6,0.385982629,1,0.06456186,5.978493048,2.579781881,0.047823264,0.02230025,"up","yes","Nr2e3","protein_coding","chr8:60366124-60373163:-","gi|7305323|ref|NP_038736.1|",1951,0,"photoreceptor-specific nuclear receptor [Mus musculus]","gi|133892966|ref|NM_013708.4|",957,0,"Mus musculus nuclear receptor subfamily 2, group E, member 3 (Nr2e3), mRNA","Q9QXZ7",756,0,"Photoreceptor-specific nuclear receptor",".",".",".",".","pfam00105","zf-C4","Zinc finger, C4 type (two domains). In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008285|negative regulation of cell proliferation;GO:0010628|positive regulation of gene expression;GO:0030154|cell differentiation;GO:0030522|intracellular receptor signaling pathway;GO:0042462|eye photoreceptor cell development;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048856|anatomical structure development;GO:0060041|retina development in camera-type eye;","GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0004879|nuclear receptor activity;GO:0008270|zinc ion binding;GO:0043565|sequence-specific DNA binding;","K08546","NR2E3, PNR; nuclear receptor subfamily 2 group E member 3"]
["ENSRNOG00000050761",6,0.385982629,1,0.06456186,5.978493048,2.579781881,0.047823264,0.02230025,"up","yes","Serpina10","protein_coding","chr6:122756108-122764544:-","gi|56961653|ref|NP_598301.2|",2256,0,"protein Z-dependent protease inhibitor precursor [Rattus norvegicus]","gi|672057051|ref|XM_003750227.3|",1596,0,"PREDICTED: Rattus norvegicus protein Z-dependent protease inhibitor-like (LOC100909524), transcript variant X1, mRNA","Q62975",873,0,"Protein Z-dependent protease inhibitor","all0778",132,{"v":2e-33,"d":"2.00E-33"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0007596|blood coagulation;GO:0010951|negative regulation of endopeptidase activity;GO:0097421|liver regeneration;","GO:0005575|cellular_component;GO:0005615|extracellular space;","GO:0003674|molecular_function;GO:0004867|serine-type endopeptidase inhibitor activity;GO:0008201|heparin binding;","K04525","SERPINA; serpin A"]
["ENSRNOG00000055586",6,0.385982629,1,0.06456186,5.978493048,2.579781881,0.047823264,0.02230025,"up","yes","ENSRNOG00000055586","protein_coding","chr11:67976794-67982396:+","gi|392332348|ref|XP_003752550.1|",741,{"v":2e-96,"d":"2.00E-96"},"PREDICTED: uncharacterized protein LOC100910650 isoform X1 [Rattus norvegicus]","gi|672026141|ref|XM_003752502.3|",743,0,"PREDICTED: Rattus norvegicus uncharacterized LOC100910650 (LOC100910650), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam01033","Somatomedin_B","Somatomedin B domain.",".",".",".",".","."]
["ENSRNOG00000057027",6,0.385982629,1,0.06456186,5.978493048,2.579781881,0.047823264,0.02230025,"up","yes","Gm22728","scaRNA","chr14:16016556-16016682:+",".",".",".",".","gi|354799112|gb|JN963613.1|",92,{"v":2e-39,"d":"2.00E-39"},"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele G3bp2:tm1a(EUCOMM)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam05749","Rubella_E2","Rubella membrane glycoprotein E2. Rubella virus (RV), the sole member of the genus Rubivirus within the family Togaviridae, is a small enveloped, positive strand RNA virus. The nucleocapsid consists of 40S genomic RNA and a single species of capsid protein which is enveloped within a host-derived lipid bilayer containing two viral glycoproteins, E1 (58 kDa) and E2 (42-46 kDa). In virus infected cells, RV matures by budding either at the plasma membrane, or at the internal membranes depending on the cell type and enters adjacent uninfected cells by a membrane fusion process in the endosome, directed by E1-E2 heterodimers. The heterodimer formation is crucial for E1 transport out of the endoplasmic reticulum to the Golgi and plasma membrane. In RV E1, a cysteine at position 82 is crucial for the E1-E2 heterodimer formation and cell surface expression of the two proteins.",".",".",".",".","."]
["ENSRNOG00000060156",6,0.385982629,1,0.06456186,5.978493048,2.579781881,0.047823264,0.02230025,"up","yes","SNORD28","snoRNA","chr1:205620424-205620501:+",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","pfam00827","Ribosomal_L15e","Ribosomal L15.",".",".",".",".","."]
["ENSRNOG00000063179",6,0.385982629,1,0.06456186,5.978493048,2.579781881,0.047823264,0.02230025,"up","yes","ENSRNOG00000063179","lncRNA","chr14:42054617-42113743:+",".",".",".",".","gi|672076157|ref|XM_006250954.2|",424,0,"PREDICTED: Rattus norvegicus RNA binding motif protein 47 (Rbm47), transcript variant X4, mRNA",".",".",".",".",".",".",".",".","pfam10783","DUF2599","Protein of unknown function (DUF2599). This family is conserved in Actinobacteria. The function is not known.",".",".",".",".","."]
["ENSRNOG00000067795",6,0.385982629,1,0.06456186,5.978493048,2.579781881,0.047823264,0.02230025,"up","yes","U6","snRNA","chr2:61082240-61082346:+","gi|965792038|ref|XP_014963564.1|",140,5e-09,"PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC106992171 [Ovis aries musimon]","gi|28372754|gb|AC124724.4|",86,{"v":3e-36,"d":"3.00E-36"},"Mus musculus BAC clone RP23-446L16 from chromosome 19, complete sequence",".",".",".",".",".",".",".",".","pfam08298","AAA_PrkA","PrkA AAA domain. This is a family of PrkA bacterial and archaeal serine kinases approximately 630 residues long. This is the N-terminal AAA domain.",".",".",".",".","."]
["ENSRNOG00000069214",6,0.385982629,1,0.06456186,5.978493048,2.579781881,0.047823264,0.02230025,"up","yes","ENSRNOG00000069214","protein_coding","chr8:55695514-55696790:+","gi|558140157|ref|XP_006092183.1|",1485,0,"PREDICTED: F-box/LRR-repeat protein 14 isoform X3 [Myotis lucifugus]","gi|158711671|ref|NM_138523.2|",491,0,"Rattus norvegicus PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae) (Prpf18), mRNA","Q8BID8",555,0,"F-box/LRR-repeat protein 14",".",".",".",".","pfam08926","DUF1908","Domain of unknown function (DUF1908). This domain is found in a set of hypothetical/structural eukaryotic proteins.",".",".",".",".","."]
["ENSRNOG00000070220",6,0.385982629,1,0.06456186,5.978493048,2.579781881,0.047823264,0.02230025,"up","yes","ENSRNOG00000070220","protein_coding","chr19:21632293-21650799:-","gi|295391809|ref|NP_001171294.1|",722,{"v":3e-93,"d":"3.00E-93"},"uncharacterized protein LOC100363129 [Rattus norvegicus]","gi|295391808|ref|NM_001177823.1|",648,0,"Rattus norvegicus LRRGT00018-like (LOC100363129), mRNA",".",".",".",".",".",".",".",".","pfam10272","Tmpp129","Putative transmembrane protein precursor. This is a family of proteins conserved from worms to humans. The proteins are purported to be transmembrane protein-precursors but the function is unknown.",".",".",".",".","."]
["ENSRNOG00000070633",6,0.385982629,1,0.06456186,5.978493048,2.579781881,0.047823264,0.02230025,"up","yes","ENSRNOG00000070633","protein_coding","chr15:24257489-24258627:+","gi|575403030|ref|NP_001276405.1|",437,{"v":4E-51,"d":"4.00E-51"},"proteasome subunit alpha type-7 isoform 2 [Mus musculus]","gi|14198317|gb|BC008222.1|",233,{"v":5E-117,"d":"5.00E-117"},"Mus musculus proteasome (prosome, macropain) subunit, alpha type 7, mRNA (cDNA clone MGC:6440 IMAGE:2581897), complete cds","O14818",173,{"v":5E-52,"d":"5.00E-52"},"Proteasome subunit alpha type-7",".",".",".",".","pfam00227","Proteasome","Proteasome subunit. The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria. The second is call beta-proteobacteria proteasome homologue (BPH).",".",".",".",".","."]
["ENSRNOG00000070980",6,0.385982629,1,0.06456186,5.978493048,2.579781881,0.047823264,0.02230025,"up","yes","ENSRNOG00000070980","lncRNA","chr8:58170918-58191455:+","gi|149041814|gb|EDL95655.1|",209,{"v":9e-19,"d":"9.00E-19"},"rCG58194, isoform CRA_b [Rattus norvegicus]","gi|672062360|ref|XR_593937.1|",330,{"v":6e-171,"d":"6.00E-171"},"PREDICTED: Rattus norvegicus uncharacterized LOC103690224 (LOC103690224), ncRNA",".",".",".",".",".",".",".",".","pfam04625","DEC-1_N","DEC-1 protein, N-terminal region. The defective chorion-1 gene (dec-1) in Drosophila encodes follicle cell proteins necessary for proper eggshell assembly. Multiple products of the dec-1 gene are formed by alternative RNA splicing and proteolytic processing. Cleavage products include S80 (80 kDa) which is incorporated into the eggshell, and further proteolysis of S80 gives S60 (60 kDa).",".",".",".",".","."]
["ENSRNOG00000019613",18,1.157947887,8,0.516494877,2.241934893,1.164744382,0.04797705,0.022359287,"up","yes","Syt9","protein_coding","chr1:161275734-161455007:+","gi|564330267|ref|XP_006230023.1|",2232,0,"PREDICTED: synaptotagmin-9 isoform X2 [Rattus norvegicus]","gi|755522995|ref|XR_378262.2|",1999,0,"PREDICTED: Mus musculus synaptotagmin IX (Syt9), transcript variant X1, misc_RNA","Q925C0",860,0,"Synaptotagmin-9","SPCP31B10.06",55.1,1e-06,"COG5038","pfam00168","C2","C2 domain.","GO:0005513|detection of calcium ion;GO:0014059|regulation of dopamine secretion;GO:0016192|vesicle-mediated transport;GO:0017156|calcium ion regulated exocytosis;GO:0017158|regulation of calcium ion-dependent exocytosis;GO:0045956|positive regulation of calcium ion-dependent exocytosis;GO:0050796|regulation of insulin secretion;GO:0071277|cellular response to calcium ion;GO:0099502|calcium-dependent activation of synaptic vesicle fusion;","GO:0005886|plasma membrane;GO:0030141|secretory granule;GO:0030285|integral component of synaptic vesicle membrane;GO:0030667|secretory granule membrane;GO:0031045|dense core granule;GO:0070382|exocytic vesicle;GO:0098686|hippocampal mossy fiber to CA3 synapse;","GO:0000149|SNARE binding;GO:0001786|phosphatidylserine binding;GO:0005509|calcium ion binding;GO:0005544|calcium-dependent phospholipid binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0019905|syntaxin binding;GO:0030276|clathrin binding;GO:0042802|identical protein binding;","K19909","SYT9; synaptotagmin-9"]
["ENSRNOG00000056434",18,1.157947887,8,0.516494877,2.241934893,1.164744382,0.04797705,0.022359287,"up","yes","Gm25663","snoRNA","chr13:55522359-55522493:+",".",".",".",".","gi|564380983|ref|XR_358970.1|",135,{"v":3e-63,"d":"3.00E-63"},"PREDICTED: Rattus norvegicus uncharacterized LOC102549528 (LOC102549528), ncRNA",".",".",".",".",".",".",".",".","pfam10143","PhosphMutase","2,3-bisphosphoglycerate-independent phosphoglycerate mutase. Members of this family are found in various bacterial 2,3-bisphosphoglycerate-independent phosphoglycerate mutase enzymes, which catalyse the interconversion of 2-phosphoglycerate and 3-phosphoglycerate in the reaction: [2-phospho-D-glycerate + 2,3-diphosphoglycerate = 3-phospho-D-glycerate + 2,3-diphosphoglycerate].",".",".",".",".","."]
["ENSRNOG00000066101",18,1.157947887,8,0.516494877,2.241934893,1.164744382,0.04797705,0.022359287,"up","yes","Gm9999","protein_coding","chr1:97524328-97529198:+","gi|148691005|gb|EDL22952.1|",181,{"v":3e-14,"d":"3.00E-14"},"mCG123190 [Mus musculus]","gi|672036780|ref|XR_145763.3|",490,0,"PREDICTED: Rattus norvegicus uncharacterized LOC100911574 (LOC100911574), transcript variant X2, ncRNA","A0A0U1RRN3",64.7,{"v":4e-12,"d":"4.00E-12"},"Putative transmembrane protein SPTY2D1OS",".",".",".",".","pfam03268","DUF267","Caenorhabditis protein of unknown function, DUF267.",".",".",".",".","."]

{"sheet":"2D_CTX_down","index":2,"n_rows":1178,"n_cols":38,"rows_kept":1178}
["Gene","2D_count","2D_normalize","CTX_count","CTX_normalize","FoldChange","Log2FoldChange","pval","padj","Up/Down","Significant","GeneName","Biotype","Position","NR:Seq-id","NR:Score","NR:Evalue","NR:Description","NT:Seq-id","NT:Score","NT:Evalue","NT:Description","Uniprot:UniProtKB-AC","Uniprot:Score","Uniprot:Evalue","Uniprot:Description","COG:gene","COG:Score","COG:Eval","COG:num","Pfam:pfam_ID","Pfam:pfam_Name","Pfam:pfam_Description","GO:biological_process","GO:cellular_component","GO:molecular_function","KEGG:KO","KEGG:Description"]
["ENSRNOG00000029886",9165,760.9393437,48066,3092.106842,0.246090896,-2.022736807,0,0,"down","yes","Hba-a2","protein_coding","chr10:15307815-15338392:-","gi|392331680|ref|XP_002724712.2|",1102,{"v":3E-148,"d":"3.00E-148"},"PREDICTED: hemoglobin subunit theta-1-like isoform X1 [Rattus norvegicus]","gi|672067068|ref|XM_002727758.4|",1089,0,"PREDICTED: Rattus norvegicus hemoglobin, theta 1B (Hbq1b), transcript variant X1, mRNA","P09105",201,{"v":1E-61,"d":"1.00E-61"},"Hemoglobin subunit theta-1",".",".",".",".","pfam00042","Globin","Globin.","GO:0001701|in utero embryonic development;GO:0009617|response to bacterium;GO:0015671|oxygen transport;GO:0035634|response to stilbenoid;GO:0042744|hydrogen peroxide catabolic process;GO:0045776|negative regulation of blood pressure;GO:0048821|erythrocyte development;GO:0051930|regulation of sensory perception of pain;GO:0098869|cellular oxidant detoxification;","GO:0005833|hemoglobin complex;GO:0031838|haptoglobin-hemoglobin complex;GO:0045202|synapse;","GO:0001540|amyloid-beta binding;GO:0004601|peroxidase activity;GO:0005344|oxygen carrier activity;GO:0005506|iron ion binding;GO:0005515|protein binding;GO:0019825|oxygen binding;GO:0020037|heme binding;GO:0031720|haptoglobin binding;GO:0043177|organic acid binding;","K13822","HBA; hemoglobin subunit alpha"]
["ENSRNOG00000017531",23102,1918.081911,76285,4907.447477,0.390851236,-1.355308495,0,0,"down","yes","Akr1c3","protein_coding","chr17:66110963-66127873:+","gi|55824739|gb|AAH86579.1|",1808,0,"Akr1c18 protein, partial [Rattus norvegicus]","gi|55824738|gb|BC086579.1|",1220,0,"Rattus norvegicus aldo-keto reductase family 1, member C18, mRNA (cDNA clone IMAGE:7307445), partial cds","P51652",674,0,"Aldo-keto reductase family 1 member C18","slr0942",214,{"v":1e-64,"d":"1.00E-64"},"COG0656","pfam00248","Aldo_ket_red","Aldo/keto reductase family. This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.","GO:0006693|prostaglandin metabolic process;GO:0006709|progesterone catabolic process;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007565|female pregnancy;GO:0007567|parturition;GO:0007584|response to nutrient;GO:0008202|steroid metabolic process;GO:0008284|positive regulation of cell proliferation;GO:0008584|male gonad development;GO:0009267|cellular response to starvation;GO:0010942|positive regulation of cell death;GO:0016488|farnesol catabolic process;GO:0030216|keratinocyte differentiation;GO:0034614|cellular response to reactive oxygen species;GO:0042448|progesterone metabolic process;GO:0042574|retinal metabolic process;GO:0043170|macromolecule metabolic process;GO:0044597|daunorubicin metabolic process;GO:0044598|doxorubicin metabolic process;GO:0048385|regulation of retinoic acid receptor signaling pathway;GO:0050810|regulation of steroid biosynthetic process;GO:0051897|positive regulation of protein kinase B signaling;GO:0061370|testosterone biosynthetic process;GO:0071276|cellular response to cadmium ion;GO:0071277|cellular response to calcium ion;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0071379|cellular response to prostaglandin stimulus;GO:0071384|cellular response to corticosteroid stimulus;GO:0071394|cellular response to testosterone stimulus;GO:0071395|cellular response to jasmonic acid stimulus;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0071799|cellular response to prostaglandin D stimulus;GO:0097211|cellular response to gonadotropin-releasing hormone;GO:1900053|negative regulation of retinoic acid biosynthetic process;GO:1904322|cellular response to forskolin;GO:1990646|cellular response to prolactin;GO:2000224|regulation of testosterone biosynthetic process;GO:2000353|positive regulation of endothelial cell apoptotic process;GO:2000379|positive regulation of reactive oxygen species metabolic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0001758|retinal dehydrogenase activity;GO:0004032|alditol:NADP+ 1-oxidoreductase activity;GO:0004033|aldo-keto reductase (NADP) activity;GO:0004745|retinol dehydrogenase activity;GO:0016229|steroid dehydrogenase activity;GO:0016655|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0018636|phenanthrene 9,10-monooxygenase activity;GO:0032052|bile acid binding;GO:0035410|dihydrotestosterone 17-beta-dehydrogenase activity;GO:0045550|geranylgeranyl reductase activity;GO:0045703|ketoreductase activity;GO:0047006|17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity;GO:0047020|15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity;GO:0047023|androsterone dehydrogenase activity;GO:0047086|ketosteroid monooxygenase activity;GO:0047787|delta4-3-oxosteroid 5beta-reductase activity;GO:0047834|D-threo-aldose 1-dehydrogenase activity;","K05295","E1.1.1.149; 20alpha-hydroxysteroid dehydrogenase [EC:1.1.1.149]"]
["ENSRNOG00000069830",2457,203.9965049,14560,936.65118,0.217793464,-2.198967437,0,0,"down","yes","ENSRNOG00000069830","protein_coding","chr3:74282149-74287593:-","gi|852749799|ref|XP_012872059.1|",1849,0,"PREDICTED: endogenous retrovirus group K member 8 Pol protein-like [Dipodomys ordii]","gi|46240867|gb|AC107531.8|",5002,0,"Rattus norvegicus 1 BAC CH230-158N3 (Children's Hospital Oakland Research Institute) complete sequence","P04026",563,0,"Intracisternal A-particle Pol-related polyprotein (Fragment)","YIL082w-a_2",80.5,{"v":4E-14,"d":"4.00E-14"},"COG2801","pfam00078","RVT_1","Reverse transcriptase (RNA-dependent DNA polymerase). A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs, hepadnaviruses, and caulimoviruses.",".",".",".",".","."]
["ENSRNOG00000013279",181,15.02782556,5601,360.3147843,0.041707491,-4.58354967,0,0,"down","yes","ENSRNOG00000013279","protein_coding","chr1:243078774-243114229:+","gi|672014957|ref|XP_008773072.1|",1789,0,"PREDICTED: acyl-CoA desaturase 1-like [Rattus norvegicus]","gi|672014956|ref|XM_008774850.1|",1268,0,"PREDICTED: Rattus norvegicus similar to stearoyl-coenzyme A desaturase 3 (LOC681458), mRNA","Q99PL7",661,0,"Acyl-CoA desaturase 3","SPCC1281.06c_1",205,{"v":4e-57,"d":"4.00E-57"},"COG1398","pfam00487","FA_desaturase","Fatty acid desaturase.","GO:0006636|unsaturated fatty acid biosynthetic process;GO:0070542|response to fatty acid;GO:1903966|monounsaturated fatty acid biosynthetic process;","GO:0005789|endoplasmic reticulum membrane;GO:0030176|integral component of endoplasmic reticulum membrane;","GO:0004768|stearoyl-CoA 9-desaturase activity;GO:0005506|iron ion binding;GO:0032896|palmitoyl-CoA 9-desaturase activity;","K00507","SCD, desC; stearoyl-CoA desaturase (Delta-9 desaturase) [EC:1.14.19.1]"]
["ENSRNOG00000071185",9037,750.3119312,26213,1686.293776,0.444947341,-1.168293491,0,0,"down","yes","ENSRNOG00000071185","lncRNA","chr4:78274962-78293658:+","gi|667282457|ref|XP_008574777.1|",340,{"v":6e-61,"d":"6.00E-61"},"PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103593548 [Galeopterus variegatus]","gi|241982901|gb|AC136178.3|",2627,0,"Rattus norvegicus CH230-435P16 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P03359",99,{"v":1E-53,"d":"1.00E-53"},"Gag-Pol polyprotein",".",".",".",".","pfam02093","Gag_p30","Gag P30 core shell protein. According to Swiss-Prot annotation this protein is the viral core shell protein. P30 is essential for viral assembly.",".",".",".",".","."]
["ENSRNOG00000029811",34,2.822906458,3874,249.2161175,0.011327142,-6.464072241,0,0,"down","yes","Kcne2","protein_coding","chr11:31295614-31530043:+","gi|19424314|ref|NP_598287.1|",657,{"v":2E-78,"d":"2.00E-78"},"potassium voltage-gated channel subfamily E member 2 [Rattus norvegicus]","gi|672070506|ref|XM_006248023.2|",2148,0,"PREDICTED: Rattus norvegicus potassium voltage-gated channel, Isk-related family, member 2 (Kcne2), transcript variant X2, mRNA","P63161",257,{"v":7e-80,"d":"7.00E-80"},"Potassium voltage-gated channel subfamily E member 2",".",".",".",".","pfam02060","ISK_Channel","Slow voltage-gated potassium channel.","GO:0007568|aging;GO:0015705|iodide transport;GO:0015798|myo-inositol transport;GO:0033555|multicellular organismal response to stress;GO:0034613|cellular protein localization;GO:0043586|tongue development;GO:0060306|regulation of membrane repolarization;GO:0060307|regulation of ventricular cardiac muscle cell membrane repolarization;GO:0071466|cellular response to xenobiotic stimulus;GO:0071805|potassium ion transmembrane transport;GO:0086002|cardiac muscle cell action potential involved in contraction;GO:0086005|ventricular cardiac muscle cell action potential;GO:0086009|membrane repolarization;GO:0086011|membrane repolarization during action potential;GO:0086091|regulation of heart rate by cardiac conduction;GO:0097623|potassium ion export across plasma membrane;GO:0098915|membrane repolarization during ventricular cardiac muscle cell action potential;GO:1901379|regulation of potassium ion transmembrane transport;GO:1901387|positive regulation of voltage-gated calcium channel activity;GO:1901800|positive regulation of proteasomal protein catabolic process;GO:1901979|regulation of inward rectifier potassium channel activity;GO:1902159|regulation of cyclic nucleotide-gated ion channel activity;GO:1902259|regulation of delayed rectifier potassium channel activity;GO:1902260|negative regulation of delayed rectifier potassium channel activity;GO:1903817|negative regulation of voltage-gated potassium channel activity;GO:1990573|potassium ion import across plasma membrane;","GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0008076|voltage-gated potassium channel complex;GO:0009986|cell surface;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0005242|inward rectifier potassium channel activity;GO:0005249|voltage-gated potassium channel activity;GO:0005251|delayed rectifier potassium channel activity;GO:0005261|cation channel activity;GO:0005515|protein binding;GO:0015459|potassium channel regulator activity;GO:0042802|identical protein binding;GO:0044325|ion channel binding;GO:1902282|voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization;","K04896","KCNE2; potassium voltage-gated channel Isk-related subfamily E member 2"]
["ENSRNOG00000047098",192,15.94111882,4055,260.8599268,0.06110988,-4.032450542,0,0,"down","yes","Hbb-b1","protein_coding","chr1:158120200-158252012:-","gi|40445397|ref|NP_942071.1|",744,{"v":1e-96,"d":"1.00E-96"},"hemoglobin, beta adult major chain [Rattus norvegicus]","gi|298901836|emb|FQ228130.1|",564,0,"Rattus norvegicus TL0AEA10YG08 mRNA sequence","P11517",284,{"v":2E-95,"d":"2.00E-95"},"Hemoglobin subunit beta-2",".",".",".",".","pfam00042","Globin","Globin.","GO:0015671|oxygen transport;GO:0098869|cellular oxidant detoxification;","GO:0005833|hemoglobin complex;","GO:0005344|oxygen carrier activity;GO:0019825|oxygen binding;GO:0020037|heme binding;GO:0046872|metal ion binding;","K13823","HBB; hemoglobin subunit beta"]
["ENSRNOG00000019018",1176,97.63935278,6728,432.8151881,0.225591327,-2.148216489,0,0,"down","yes","Plat","protein_coding","chr16:69240585-69268223:-","gi|564389730|ref|XP_006253409.1|",2820,0,"PREDICTED: tissue-type plasminogen activator isoform X2 [Rattus norvegicus]","gi|672080489|ref|XM_006253347.2|",2441,0,"PREDICTED: Rattus norvegicus plasminogen activator, tissue (Plat), transcript variant X1, mRNA","P19637",1067,0,"Tissue-type plasminogen activator","mlr3307",109,{"v":8e-25,"d":"8.00E-25"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0001666|response to hypoxia;GO:0006508|proteolysis;GO:0014909|smooth muscle cell migration;GO:0031639|plasminogen activation;GO:0035249|synaptic transmission, glutamatergic;GO:0042060|wound healing;GO:0045861|negative regulation of proteolysis;GO:0048008|platelet-derived growth factor receptor signaling pathway;GO:0048167|regulation of synaptic plasticity;GO:0051591|response to cAMP;GO:0060279|positive regulation of ovulation;GO:0060468|prevention of polyspermy;GO:0070542|response to fatty acid;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0071373|cellular response to luteinizing hormone stimulus;GO:0071549|cellular response to dexamethasone stimulus;GO:0099183|trans-synaptic signaling by BDNF, modulating synaptic transmission;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0009986|cell surface;GO:0030141|secretory granule;GO:0045177|apical part of cell;GO:0045202|synapse;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098794|postsynapse;GO:0098978|glutamatergic synapse;GO:0098992|neuronal dense core vesicle;GO:0099544|perisynaptic space;","GO:0003674|molecular_function;GO:0004252|serine-type endopeptidase activity;GO:0005102|signaling receptor binding;GO:0051219|phosphoprotein binding;","K01343","PLAT; tissue plasminogen activator [EC:3.4.21.68]"]
["ENSRNOG00000071023",3191,264.9380737,11016,708.664107,0.373855641,-1.419446795,0,0,"down","yes","Zfp347","protein_coding","chr7:7459701-7484430:+","gi|149034382|gb|EDL89119.1|",3574,0,"rCG29513 [Rattus norvegicus]","gi|19173743|ref|NM_133390.1|",2340,0,"Rattus norvegicus zinc finger protein 347 (Zfp347), mRNA","Q5TYW1",595,{"v":3e-180,"d":"3.00E-180"},"Zinc finger protein 658",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000068973",48,3.985279705,2998,192.8626537,0.020663823,-5.596749011,0,0,"down","yes","ENSRNOG00000068973","protein_coding","chr1:15046564-15050125:-","gi|45478088|gb|AAS66215.1|",680,{"v":1e-77,"d":"1.00E-77"},"LRRG00124 [Rattus norvegicus]","gi|34555688|gb|AY343914.1|",520,0,"Rattus norvegicus genomic sequence","P11369",230,{"v":8e-69,"d":"8.00E-69"},"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam12488","DUF3704","Protein of unknown function (DUF3704). This domain family is found in eukaryotes, and is approximately 30 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000015354",1564,129.8536971,7281,468.3899204,0.277234183,-1.85082294,0,0,"down","yes","Aox1","protein_coding","chr9:59579649-59658770:+","gi|149046117|gb|EDL99010.1|",6822,0,"aldehyde oxidase 1 [Rattus norvegicus]","gi|281599344|gb|AC115467.4|",4219,0,"Rattus norvegicus BAC CH230-184L19 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q9Z0U5",2627,0,"Aldehyde oxidase 1","PA1523",497,{"v":2e-151,"d":"2.00E-151"},"COG4631","pfam02738","Ald_Xan_dh_C2","Molybdopterin-binding domain of aldehyde dehydrogenase.","GO:0006805|xenobiotic metabolic process;","GO:0005829|cytosol;","GO:0004031|aldehyde oxidase activity;GO:0005506|iron ion binding;GO:0016491|oxidoreductase activity;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0043546|molybdopterin cofactor binding;GO:0050250|retinal oxidase activity;GO:0050660|flavin adenine dinucleotide binding;GO:0051287|NAD binding;GO:0051537|2 iron, 2 sulfur cluster binding;GO:0071949|FAD binding;GO:0102797|geranial:oxygen oxidoreductase activity;GO:0102798|heptaldehyde:oxygen oxidoreductase activity;","K00157","AOX; aldehyde oxidase [EC:1.2.3.1]"]
["ENSRNOG00000005387",3484,289.2648853,11445,736.261865,0.392883156,-1.347827778,0,0,"down","yes","ENSRNOG00000005387","protein_coding","chrX:14348910-14353580:+","gi|148702008|gb|EDL33955.1|",492,{"v":8e-54,"d":"8.00E-54"},"mCG116386, isoform CRA_e, partial [Mus musculus]","gi|564398624|ref|XM_006256694.1|",686,0,"PREDICTED: Rattus norvegicus RNA binding motif (RNP1, RRM) protein 3 (Rbm3), transcript variant X1, mRNA","O89086",177,{"v":9e-50,"d":"9.00E-50"},"RNA-binding protein 3","TP0356",72.4,{"v":8E-14,"d":"8.00E-14"},"COG0724","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0006412|translation;GO:0006417|regulation of translation;GO:0009409|response to cold;GO:0035196|production of miRNAs involved in gene silencing by miRNA;GO:0045727|positive regulation of translation;GO:0048026|positive regulation of mRNA splicing, via spliceosome;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005681|spliceosomal complex;GO:0005737|cytoplasm;GO:0030425|dendrite;","GO:0003723|RNA binding;GO:0005515|protein binding;GO:0043023|ribosomal large subunit binding;","K13186","RBM3; RNA-binding protein 3"]
["ENSRNOG00000068679",882,73.22951458,5064,325.769339,0.224789462,-2.153353688,0,0,"down","yes","Rpl30","lncRNA","chr7:65645991-65651363:-","gi|589934517|ref|XP_006980039.1|",329,{"v":1e-31,"d":"1.00E-31"},"PREDICTED: 60S ribosomal protein L30-like [Peromyscus maniculatus bairdii]","gi|435126|gb|K02928.1|MUSRPL30",469,0,"Mouse ribosomal protein L30 gene, complete cds","P62890",130,{"v":4e-33,"d":"4.00E-33"},"60S ribosomal protein L30","SPAC1250.05",88.2,{"v":8e-19,"d":"8.00E-19"},"COG1911","pfam01248","Ribosomal_L7Ae","Ribosomal protein L7Ae/L30e/S12e/Gadd45 family. This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118.",".",".",".",".","."]
["ENSRNOG00000067242",829,68.82910158,4457,286.720763,0.240056217,-2.058555798,0,0,"down","yes","ENSRNOG00000067242","protein_coding","chrX:111691855-111700281:-","gi|148676020|gb|EDL07967.1|",1103,{"v":4e-135,"d":"4.00E-135"},"mCG1029965 [Mus musculus]","gi|46240867|gb|AC107531.8|",2301,0,"Rattus norvegicus 1 BAC CH230-158N3 (Children's Hospital Oakland Research Institute) complete sequence","P31789",206,{"v":3e-55,"d":"3.00E-55"},"Envelope glycoprotein",".",".",".",".","pfam00517","GP41","Retroviral envelope protein. This family includes envelope protein from a variety of retroviruses. It includes the GP41 subunit of the envelope protein complex from human and simian immunodeficiency viruses (HIV and SIV) which mediate membrane fusion during viral entry. The family also includes bovine immunodeficiency virus, feline immunodeficiency virus and Equine infectious anaemia (EIAV). The family also includes the Gp36 protein from mouse mammary tumor virus (MMTV) and human endogenous retroviruses (HERVs).",".",".",".",".","."]
["ENSRNOG00000003687",1078,89.50274005,5012,322.4241562,0.277593159,-1.84895608,0,0,"down","yes","Rgs2","protein_coding","chr13:55798829-55802385:-","gi|16758194|ref|NP_445905.1|",1018,{"v":6e-133,"d":"6.00E-133"},"regulator of G-protein signaling 2 [Rattus norvegicus]","gi|298897112|emb|FQ224353.1|",1632,0,"Rattus norvegicus TL0ACA69YI09 mRNA sequence","Q9JHX0",396,{"v":2e-134,"d":"2.00E-134"},"Regulator of G-protein signaling 2",".",".",".",".","pfam00615","RGS","Regulator of G protein signaling domain. RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.","GO:0001975|response to amphetamine;GO:0007283|spermatogenesis;GO:0007420|brain development;GO:0008277|regulation of G protein-coupled receptor signaling pathway;GO:0010519|negative regulation of phospholipase activity;GO:0010614|negative regulation of cardiac muscle hypertrophy;GO:0010976|positive regulation of neuron projection development;GO:0017148|negative regulation of translation;GO:0030728|ovulation;GO:0043407|negative regulation of MAP kinase activity;GO:0045471|response to ethanol;GO:0045744|negative regulation of G protein-coupled receptor signaling pathway;GO:0050873|brown fat cell differentiation;GO:0055119|relaxation of cardiac muscle;GO:0060087|relaxation of vascular smooth muscle;GO:0060135|maternal process involved in female pregnancy;GO:0060452|positive regulation of cardiac muscle contraction;GO:0061052|negative regulation of cell growth involved in cardiac muscle cell development;GO:0140194|negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process;GO:1900924|negative regulation of glycine import across plasma membrane;","GO:0005634|nucleus;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0009898|cytoplasmic side of plasma membrane;GO:0043005|neuron projection;","GO:0001965|G-protein alpha-subunit binding;GO:0005096|GTPase activator activity;GO:0010855|adenylate cyclase inhibitor activity;GO:0048487|beta-tubulin binding;","K18154","RGS2; regulator of G-protein signaling 2"]
["ENSRNOG00000017481",2133,177.0958669,7053,453.7225805,0.390317508,-1.357279918,0,0,"down","yes","Sucla2","protein_coding","chr15:48752312-48805138:+","gi|158749584|ref|NP_001101857.2|",2242,0,"succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial [Rattus norvegicus]","gi|158749583|ref|NM_001108387.2|",1325,0,"Rattus norvegicus succinate-CoA ligase, ADP-forming, beta subunit (Sucla2), mRNA","Q9Z2I9",832,0,"Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial","SPCC1620.08",448,{"v":8e-149,"d":"8.00E-149"},"COG0045","pfam08442","ATP-grasp_2","ATP-grasp domain.","GO:0006099|tricarboxylic acid cycle;GO:0006104|succinyl-CoA metabolic process;GO:0006105|succinate metabolic process;","GO:0005739|mitochondrion;GO:0042709|succinate-CoA ligase complex;","GO:0000287|magnesium ion binding;GO:0004775|succinate-CoA ligase (ADP-forming) activity;GO:0004776|succinate-CoA ligase (GDP-forming) activity;GO:0005524|ATP binding;","K01900","LSC2; succinyl-CoA synthetase beta subunit [EC:6.2.1.4 6.2.1.5]"]
["ENSRNOG00000017243",834,69.24423488,4114,264.6554227,0.261639207,-1.934349349,0,0,"down","yes","Bnip3","protein_coding","chr1:193708167-193725359:-","gi|16758160|ref|NP_445872.1|",711,{"v":2e-84,"d":"2.00E-84"},"BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [Rattus norvegicus]","gi|186973219|gb|AC131400.5|",2082,0,"Rattus norvegicus BAC CH230-139P17 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","O55003",276,{"v":4e-85,"d":"4.00E-85"},"BCL2/adenovirus E1B 19 kDa protein-interacting protein 3",".",".",".",".","pfam06553","BNIP3","BNIP3. This family consists of several mammalian specific BCL2/adenovirus E1B 19-kDa protein-interacting protein 3 or BNIP3 sequences. BNIP3 belongs to the Bcl-2 homology 3 (BH3)-only family, a Bcl-2-related family possessing an atypical Bcl-2 homology 3 (BH3) domain, which regulates PCD from mitochondrial sites by selective Bcl-2/Bcl-XL interactions. BNIP3 family members contain a C-terminal transmembrane domain that is required for their mitochondrial localisation, homodimerization, as well as regulation of their pro-apoptotic activities. BNIP3-mediated apoptosis has been reported to be independent of caspase activation and cytochrome c release and is characterized by early plasma membrane and mitochondrial damage, prior to the appearance of chromatin condensation or DNA fragmentation.","GO:0001666|response to hypoxia;GO:0006915|apoptotic process;GO:0008219|cell death;GO:0009617|response to bacterium;GO:0010637|negative regulation of mitochondrial fusion;GO:0010659|cardiac muscle cell apoptotic process;GO:0010666|positive regulation of cardiac muscle cell apoptotic process;GO:0010821|regulation of mitochondrion organization;GO:0010917|negative regulation of mitochondrial membrane potential;GO:0010940|positive regulation of necrotic cell death;GO:0016239|positive regulation of macroautophagy;GO:0021987|cerebral cortex development;GO:0035694|mitochondrial protein catabolic process;GO:0043065|positive regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0043067|regulation of programmed cell death;GO:0043068|positive regulation of programmed cell death;GO:0043243|positive regulation of protein complex disassembly;GO:0043653|mitochondrial fragmentation involved in apoptotic process;GO:0045837|negative regulation of membrane potential;GO:0046902|regulation of mitochondrial membrane permeability;GO:0048102|autophagic cell death;GO:0048678|response to axon injury;GO:0048709|oligodendrocyte differentiation;GO:0050873|brown fat cell differentiation;GO:0051402|neuron apoptotic process;GO:0051561|positive regulation of mitochondrial calcium ion concentration;GO:0051607|defense response to virus;GO:0055093|response to hyperoxia;GO:0060548|negative regulation of cell death;GO:0070301|cellular response to hydrogen peroxide;GO:0071260|cellular response to mechanical stimulus;GO:0071279|cellular response to cobalt ion;GO:0071456|cellular response to hypoxia;GO:0072593|reactive oxygen species metabolic process;GO:0090141|positive regulation of mitochondrial fission;GO:0090200|positive regulation of release of cytochrome c from mitochondria;GO:0090649|response to oxygen-glucose deprivation;GO:0097193|intrinsic apoptotic signaling pathway;GO:0097345|mitochondrial outer membrane permeabilization;GO:1901998|toxin transport;GO:1902109|negative regulation of mitochondrial membrane permeability involved in apoptotic process;GO:1903599|positive regulation of autophagy of mitochondrion;GO:1903715|regulation of aerobic respiration;GO:1990144|intrinsic apoptotic signaling pathway in response to hypoxia;GO:2000378|negative regulation of reactive oxygen species metabolic process;","GO:0005634|nucleus;GO:0005635|nuclear envelope;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0005783|endoplasmic reticulum;GO:0014069|postsynaptic density;GO:0030425|dendrite;GO:0031307|integral component of mitochondrial outer membrane;GO:0031966|mitochondrial membrane;","GO:0005515|protein binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0051020|GTPase binding;","K15464","BNIP3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3"]
["ENSRNOG00000020361",2170,180.1678533,7036,452.6289631,0.398047558,-1.328987284,0,0,"down","yes","Ip6k2","protein_coding","chr8:109484310-109510166:+","gi|961743782|ref|XP_014932518.1|",2223,0,"PREDICTED: inositol hexakisphosphate kinase 2 isoform X1 [Acinonyx jubatus]","gi|672063133|ref|XM_008766564.1|",1550,0,"PREDICTED: Rattus norvegicus inositol hexakisphosphate kinase 2 (Ip6k2), transcript variant X1, mRNA","Q9R0U1",843,0,"Inositol hexakisphosphate kinase 2",".",".",".",".","pfam03770","IPK","Inositol polyphosphate kinase. ArgRIII has has been demonstrated to be an inositol polyphosphate kinase.","GO:0006817|phosphate ion transport;GO:0016310|phosphorylation;GO:0030308|negative regulation of cell growth;GO:0032958|inositol phosphate biosynthetic process;GO:0043065|positive regulation of apoptotic process;GO:0043647|inositol phosphate metabolic process;GO:0046854|phosphatidylinositol phosphorylation;GO:1905396|cellular response to flavonoid;","GO:0001650|fibrillar center;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0030054|cell junction;","GO:0000828|inositol hexakisphosphate kinase activity;GO:0000832|inositol hexakisphosphate 5-kinase activity;GO:0005524|ATP binding;GO:0016301|kinase activity;GO:0097243|flavonoid binding;","K07756","IP6K, IHPK; inositol-hexakisphosphate 5-kinase [EC:2.7.4.21]"]
["ENSRNOG00000005513",4077,338.499695,10554,678.9434446,0.498568324,-1.004136871,0,0,"down","yes","Srsf5","protein_coding","chr6:100605456-100610177:+","gi|119601416|gb|EAW81010.1|",717,{"v":8e-89,"d":"8.00E-89"},"splicing factor, arginine/serine-rich 5, isoform CRA_e, partial [Homo sapiens]","gi|306774129|ref|NM_001195506.1|",1383,0,"Rattus norvegicus serine/arginine-rich splicing factor 5 (Srsf5), transcript variant 3, mRNA","Q09167",280,{"v":3e-89,"d":"3.00E-89"},"Serine/arginine-rich splicing factor 5","SPAC16.02c",133,{"v":7e-34,"d":"7.00E-34"},"COG0724","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0000398|mRNA splicing, via spliceosome;GO:0001889|liver development;GO:0009611|response to wounding;GO:0032868|response to insulin;GO:0032869|cellular response to insulin stimulus;GO:0033120|positive regulation of RNA splicing;GO:0051726|regulation of cell cycle;GO:0097421|liver regeneration;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005829|cytosol;GO:0016607|nuclear speck;","GO:0003723|RNA binding;GO:0003729|mRNA binding;GO:0005515|protein binding;GO:0043422|protein kinase B binding;GO:0050733|RS domain binding;","K12893","SRSF4_5_6, SFRS4_5_6; serine/arginine-rich splicing factor 4/5/6"]
["ENSRNOG00000005371",1402,116.4033781,5140,330.6584523,0.35203509,-1.506208854,0,0,"down","yes","Klhl29","protein_coding","chr6:28086489-28390647:-","gi|28972876|dbj|BAC65854.1|",4441,0,"mKIAA1921 protein [Mus musculus]","gi|256818757|ref|NM_001106713.2|",6980,0,"Rattus norvegicus kelch-like family member 29 (Klhl29), mRNA","Q80T74",1571,0,"Kelch-like protein 29",".",".",".",".","pfam07707","BACK","BTB And C-terminal Kelch. This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).",".",".",".","K10465","KLHL29, KBTBD9; kelch-like protein 29"]
["ENSRNOG00000016479",668,55.46180923,3350,215.5069679,0.257355063,-1.958167932,{"v":4.3931e-304,"d":"4.39E-304"},{"v":3.1211e-302,"d":"3.12E-302"},"down","yes","Plekhg4","protein_coding","chr19:33249706-33266357:+","gi|564395506|ref|XP_006255545.1|",5844,0,"PREDICTED: puratrophin-1 [Rattus norvegicus]","gi|672031236|ref|XM_008774228.1|",3828,0,"PREDICTED: Rattus norvegicus pleckstrin homology domain containing, family G (with RhoGef domain) member 4 (Plekhg4), mRNA","Q58EX7",1590,0,"Puratrophin-1",".",".",".",".","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0008150|biological_process;GO:0090630|activation of GTPase activity;","GO:0005575|cellular_component;","GO:0003674|molecular_function;GO:0005085|guanyl-nucleotide exchange factor activity;","K23860","PLEKHG4; pleckstrin homology domain-containing family G member 4"]
["ENSRNOG00000064007",683,56.70720914,3264,209.9745502,0.270067058,-1.888610418,{"v":1.7535e-282,"d":"1.75E-282"},{"v":1.0992E-280,"d":"1.10E-280"},"down","yes","ENSRNOG00000064007","protein_coding","chrX:40582255-40585197:-","gi|947316624|ref|XP_014448704.1|",568,{"v":5e-88,"d":"5.00E-88"},"PREDICTED: endogenous retrovirus group K member 18 Pol protein-like [Tupaia chinensis]","gi|153791782|ref|NG_006339.2|",1123,0,"Rattus norvegicus vomeronasal 2 receptor, pseudogene 55 (Vom2r-ps55) on chromosome 1","P04026",210,{"v":2e-81,"d":"2.00E-81"},"Intracisternal A-particle Pol-related polyprotein (Fragment)",".",".",".",".","pfam00665","rve","Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyses the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.",".",".",".",".","."]
["ENSRNOG00000019962",437,36.28265065,2609,167.8381132,0.216176469,-2.209718603,{"v":1.3802e-276,"d":"1.38E-276"},{"v":8.0964e-275,"d":"8.10E-275"},"down","yes","Sars2","protein_coding","chr1:84028986-84040725:+","gi|157819737|ref|NP_001099710.1|",2578,0,"serine--tRNA ligase, mitochondrial [Rattus norvegicus]","gi|157819736|ref|NM_001106240.1|",1859,0,"Rattus norvegicus seryl-tRNA synthetase 2, mitochondrial (Sars2), mRNA","Q9JJL8",966,0,"Serine--tRNA ligase, mitochondrial","BB0226",268,{"v":2e-81,"d":"2.00E-81"},"COG0172","pfam00587","tRNA-synt_2b","tRNA synthetase class II core domain (G, H, P, S and T). Other tRNA synthetase sub-families are too dissimilar to be included. This domain is the core catalytic domain of tRNA synthetases and includes glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases.","GO:0006434|seryl-tRNA aminoacylation;GO:0070158|mitochondrial seryl-tRNA aminoacylation;GO:0097056|selenocysteinyl-tRNA(Sec) biosynthetic process;","GO:0005739|mitochondrion;","GO:0000049|tRNA binding;GO:0004828|serine-tRNA ligase activity;GO:0005524|ATP binding;","K01875","SARS, serS; seryl-tRNA synthetase [EC:6.1.1.11]"]
["ENSRNOG00000027847",690,57.28839576,3198,205.7287413,0.278465689,-1.844428516,{"v":3.7207e-268,"d":"3.72E-268"},{"v":2.1242e-266,"d":"2.12E-266"},"down","yes","Nxpe2","protein_coding","chr8:48661708-48698035:-","gi|149041573|gb|EDL95414.1|",2880,0,"rCG58102, isoform CRA_b [Rattus norvegicus]","gi|672022774|ref|XM_003754424.3|",3044,0,"PREDICTED: Rattus norvegicus neurexophilin and PC-esterase domain family, member 2 (Nxpe2), transcript variant X1, mRNA","Q3U095",961,0,"NXPE family member 2",".",".",".",".","pfam06312","Neurexophilin","Neurexophilin. This family consists of mammalian neurexophilin proteins. Mammalian brains contain four different neurexophilin proteins. Neurexophilins form a family of related glycoproteins that are proteolytically processed after synthesis and bind to alpha-neurexins. The structure and characteristics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000017283",1068,88.67247344,4049,260.4739442,0.340427422,-1.55458084,{"v":1.0614e-266,"d":"1.06E-266"},{"v":6.0058e-265,"d":"6.01E-265"},"down","yes","Kcnt1","protein_coding","chr3:8682113-8736667:+","gi|564339775|ref|XP_006233769.1|",6032,0,"PREDICTED: potassium channel subfamily T member 1 isoform X11 [Rattus norvegicus]","gi|672044814|ref|XM_006233707.2|",4683,0,"PREDICTED: Rattus norvegicus potassium channel, subfamily T, member 1 (Kcnt1), transcript variant X11, mRNA","Q9Z258",2244,0,"Potassium channel subfamily T member 1",".",".",".",".","pfam03493","BK_channel_a","Calcium-activated BK potassium channel alpha subunit.","GO:0006813|potassium ion transport;GO:0071805|potassium ion transmembrane transport;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0005228|intracellular sodium activated potassium channel activity;GO:0005267|potassium channel activity;GO:0015271|outward rectifier potassium channel activity;","K04946","KCNT1, KNA1.1; potassium channel subfamily T member 1"]
["ENSRNOG00000049911",1149,95.39763294,4199,270.1235099,0.353163014,-1.501593834,{"v":7.2871E-263,"d":"7.29E-263"},{"v":4.0872E-261,"d":"4.09E-261"},"down","yes","Cbr1","protein_coding","chr11:32857991-32895275:+","gi|564376239|ref|XP_006248171.1|",1663,0,"PREDICTED: carbonyl reductase [NADPH] 1 [Rattus norvegicus]","gi|1217650|emb|X95986.1|",1480,0,"R.norvegicus CBR gene","P47727",546,0,"Carbonyl reductase [NADPH] 1","all0352",126,{"v":1e-30,"d":"1.00E-30"},"COG1028","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.",".",".","GO:0004090|carbonyl reductase (NADPH) activity;GO:0016491|oxidoreductase activity;","K00079","CBR1; carbonyl reductase 1 [EC:1.1.1.184 1.1.1.189 1.1.1.197]"]
["ENSRNOG00000062568",854,70.90476809,3498,225.0278728,0.315093269,-1.666149158,{"v":1.0205E-254,"d":"1.02E-254"},{"v":5.6252e-253,"d":"5.63E-253"},"down","yes","ENSRNOG00000062568","protein_coding","chr8:5386797-5392957:+","gi|852807785|ref|XP_012892095.1|",457,{"v":5e-67,"d":"5.00E-67"},"PREDICTED: uncharacterized protein LOC106001575 [Dipodomys ordii]","gi|345091104|gb|AC244812.3|",764,0,"Rattus norvegicus Y Chr BAC RNAEX-259L10 (Amplicon Express Rat SHR-Akr BAC library) complete sequence","P12894",187,{"v":2e-65,"d":"2.00E-65"},"Intracisternal A-particle Pol-related polyprotein (Fragment)",".",".",".",".","pfam02994","Transposase_22","L1 transposable element.",".",".",".",".","."]
["ENSRNOG00000006052",2306,191.4594792,6338,407.7263172,0.469578418,-1.090561991,{"v":1.5824E-241,"d":"1.58E-241"},{"v":8.0945e-240,"d":"8.09E-240"},"down","yes","Sulf2","protein_coding","chr3:154822085-154904415:-","gi|672048121|ref|XP_008760728.1|",4655,0,"PREDICTED: extracellular sulfatase Sulf-2 isoform X2 [Rattus norvegicus]","gi|110626130|ref|NM_001034927.1|",4172,0,"Rattus norvegicus sulfatase 2 (Sulf2), mRNA","Q8CFG0",1685,0,"Extracellular sulfatase Sulf-2","yidJ",95.9,{"v":2E-19,"d":"2.00E-19"},"COG3119","pfam12548","DUF3740","Sulfatase protein. This domain family is found in eukaryotes, and is typically between 144 and 173 amino acids in length. The family is found in association with pfam00884.","GO:0001822|kidney development;GO:0002063|chondrocyte development;GO:0003094|glomerular filtration;GO:0009611|response to wounding;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0014846|esophagus smooth muscle contraction;GO:0030177|positive regulation of Wnt signaling pathway;GO:0030201|heparan sulfate proteoglycan metabolic process;GO:0032836|glomerular basement membrane development;GO:0035860|glial cell-derived neurotrophic factor receptor signaling pathway;GO:0040037|negative regulation of fibroblast growth factor receptor signaling pathway;GO:0048706|embryonic skeletal system development;GO:0051216|cartilage development;GO:0060348|bone development;GO:0060384|innervation;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:0097421|liver regeneration;GO:2000345|regulation of hepatocyte proliferation;","GO:0005615|extracellular space;GO:0005783|endoplasmic reticulum;GO:0005795|Golgi stack;GO:0005886|plasma membrane;GO:0009986|cell surface;","GO:0004065|arylsulfatase activity;GO:0005509|calcium ion binding;GO:0005539|glycosaminoglycan binding;GO:0008449|N-acetylglucosamine-6-sulfatase activity;","K14607","SULF; extracellular sulfatase Sulf [EC:3.1.6.-]"]
["ENSRNOG00000050317",1670,138.6545231,5103,328.2782261,0.42236893,-1.243424383,{"v":9.3474e-240,"d":"9.35E-240"},{"v":4.6694e-238,"d":"4.67E-238"},"down","yes","Uhrf1bp1l","protein_coding","chr7:24181644-24261720:+","gi|157816897|ref|NP_001102223.1|",7599,0,"UHRF1-binding protein 1-like [Rattus norvegicus]","gi|157816896|ref|NM_001108753.1|",7053,0,"Rattus norvegicus UHRF1 binding protein 1-like (Uhrf1bp1l), mRNA","A2RSJ4",2660,0,"UHRF1-binding protein 1-like",".",".",".",".","pfam12624","Chorein_N","N-terminal region of Chorein, a TM vesicle-mediated sorter. Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.",".","GO:0005769|early endosome;GO:0005829|cytosol;","GO:0042803|protein homodimerization activity;GO:0062069|GARP complex binding;",".","."]
["ENSRNOG00000020579",375,31.1349977,2234,143.7141989,0.216645244,-2.206593529,{"v":9.9938e-237,"d":"9.99E-237"},{"v":4.841e-235,"d":"4.84E-235"},"down","yes","Col7a1","protein_coding","chr8:109604861-109637252:+","gi|157819015|ref|NP_001100328.1|",6441,0,"collagen alpha-1(VII) chain precursor [Rattus norvegicus]","gi|672062939|ref|XM_006243759.2|",9219,0,"PREDICTED: Rattus norvegicus collagen, type VII, alpha 1 (Col7a1), transcript variant X1, mRNA","Q63870",2256,0,"Collagen alpha-1(VII) chain",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0008150|biological_process;GO:0035987|endodermal cell differentiation;","GO:0005575|cellular_component;GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0062023|collagen-containing extracellular matrix;","GO:0003674|molecular_function;GO:0042802|identical protein binding;","K16628","COL7A; collagen type VII alpha"]
["ENSRNOG00000053239",503,41.76241024,2544,163.6566347,0.255183117,-1.970395209,{"v":2.528e-233,"d":"2.53E-233"},{"v":1.1974e-231,"d":"1.20E-231"},"down","yes","Clmp","protein_coding","chr8:41060799-41168838:+","gi|35215304|ref|NP_775177.1|",1573,0,"CXADR-like membrane protein precursor [Rattus norvegicus]","gi|35215303|ref|NM_173154.1|",3862,0,"Rattus norvegicus CXADR-like membrane protein (Clmp), mRNA","Q8K1G0",610,0,"CXADR-like membrane protein",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0008150|biological_process;GO:0048565|digestive tract development;","GO:0005881|cytoplasmic microtubule;GO:0005886|plasma membrane;GO:0005923|bicellular tight junction;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;","K06789","ASAM, CLMP; adipocyte-specific adhesion molecule"]
["ENSRNOG00000019830",1871,155.3428818,5416,348.4136532,0.445857619,-1.165345024,{"v":9.8642e-230,"d":"9.86E-230"},{"v":4.6038E-228,"d":"4.60E-228"},"down","yes","Hsd17b1","protein_coding","chr10:86009728-86011927:+","gi|6981048|ref|NP_036983.1|",1809,0,"estradiol 17-beta-dehydrogenase 1 [Rattus norvegicus]","gi|402693121|ref|NM_012851.2|",1418,0,"Rattus norvegicus hydroxysteroid (17-beta) dehydrogenase 1 (Hsd17b1), mRNA","P51657",701,0,"Estradiol 17-beta-dehydrogenase 1","CAC3335",122,{"v":1e-30,"d":"1.00E-30"},"COG1028","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.","GO:0006703|estrogen biosynthetic process;GO:0060348|bone development;GO:0061370|testosterone biosynthetic process;GO:0071248|cellular response to metal ion;","GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004303|estradiol 17-beta-dehydrogenase activity;GO:0005496|steroid binding;GO:0030283|testosterone dehydrogenase [NAD(P)] activity;GO:0042803|protein homodimerization activity;GO:0044594|17-beta-hydroxysteroid dehydrogenase (NAD+) activity;GO:0047035|testosterone dehydrogenase (NAD+) activity;GO:0050661|NADP binding;GO:0070401|NADP+ binding;GO:0072582|17-beta-hydroxysteroid dehydrogenase (NADP+) activity;GO:1903924|estradiol binding;","K00044","HSD17B1; 17beta-estradiol 17-dehydrogenase [EC:1.1.1.62]"]
["ENSRNOG00000015160",1083,89.91787335,3801,244.5199955,0.36773219,-1.443272626,{"v":1.2722E-224,"d":"1.27E-224"},{"v":5.7693e-223,"d":"5.77E-223"},"down","yes","Gem","protein_coding","chr5:25214309-25225222:+","gi|157817444|ref|NP_001100107.1|",1509,0,"GTP-binding protein GEM [Rattus norvegicus]","gi|157817443|ref|NM_001106637.1|",2093,0,"Rattus norvegicus GTP binding protein overexpressed in skeletal muscle (Gem), mRNA","P55041",571,0,"GTP-binding protein GEM",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0000278|mitotic cell cycle;GO:0051276|chromosome organization;GO:0051310|metaphase plate congression;","GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0009898|cytoplasmic side of plasma membrane;GO:0030496|midbody;GO:0051233|spindle midzone;GO:0072686|mitotic spindle;","GO:0000287|magnesium ion binding;GO:0003924|GTPase activity;GO:0005246|calcium channel regulator activity;GO:0005525|GTP binding;GO:0019003|GDP binding;","K07846","GEM; GTP binding protein overexpressed in skeletal muscle"]
["ENSRNOG00000011861",156,12.95215904,1536,98.81155305,0.1310794,-2.931487126,{"v":1.4625E-223,"d":"1.46E-223"},{"v":6.5393e-222,"d":"6.54E-222"},"down","yes","Aadat","protein_coding","chr16:29509394-29544332:-","gi|8393641|ref|NP_058889.1|",2022,0,"kynurenine/alpha-aminoadipate aminotransferase, mitochondrial [Rattus norvegicus]","gi|672080048|ref|XM_006253067.2|",1326,0,"PREDICTED: Rattus norvegicus aminoadipate aminotransferase (Aadat), transcript variant X1, mRNA","Q64602",783,0,"Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial","SPCC569.07",225,{"v":2e-65,"d":"2.00E-65"},"COG1167","pfam00155","Aminotran_1_2","Aminotransferase class I and II.","GO:0006103|2-oxoglutarate metabolic process;GO:0006536|glutamate metabolic process;GO:0009058|biosynthetic process;GO:0033512|L-lysine catabolic process to acetyl-CoA via saccharopine;GO:0070189|kynurenine metabolic process;GO:0097052|L-kynurenine metabolic process;GO:1901605|alpha-amino acid metabolic process;","GO:0005739|mitochondrion;","GO:0003824|catalytic activity;GO:0008483|transaminase activity;GO:0016212|kynurenine-oxoglutarate transaminase activity;GO:0030170|pyridoxal phosphate binding;GO:0042803|protein homodimerization activity;GO:0047536|2-aminoadipate transaminase activity;","K00825","AADAT, KAT2; kynurenine/2-aminoadipate aminotransferase [EC:2.6.1.7 2.6.1.39]"]
["ENSRNOG00000063373",272,22.58325166,1857,119.4616237,0.189041894,-2.403222103,{"v":3.3801e-218,"d":"3.38E-218"},{"v":1.4505e-216,"d":"1.45E-216"},"down","yes","Socs3","protein_coding","chr10:103193537-103197787:-","gi|672069906|ref|XP_008766620.1|",1113,{"v":2e-141,"d":"2.00E-141"},"PREDICTED: suppressor of cytokine signaling 3 isoform X1 [Rattus norvegicus]","gi|672069905|ref|XM_008768398.1|",2480,0,"PREDICTED: Rattus norvegicus suppressor of cytokine signaling 3 (Socs3), transcript variant X1, mRNA","O88583",428,{"v":4e-141,"d":"4.00E-141"},"Suppressor of cytokine signaling 3",".",".",".",".","pfam00017","SH2","SH2 domain.",".",".",".",".","."]
["ENSRNOG00000010389",1193,99.05080601,3963,254.9415265,0.388523625,-1.363925768,{"v":4.4652E-215,"d":"4.47E-215"},{"v":1.8783e-213,"d":"1.88E-213"},"down","yes","Ndrg2","protein_coding","chr15:24600982-24609626:-","gi|354505215|ref|XP_003514667.1|",1751,0,"PREDICTED: protein NDRG2 isoform X1 [Cricetulus griseus]","gi|399498532|ref|NM_001270863.1|",1960,0,"Rattus norvegicus NDRG family member 2 (Ndrg2), transcript variant 3, mRNA","Q9QYG0",672,0,"Protein NDRG2",".",".",".",".","pfam03096","Ndr","Ndr family. This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, and Ndr3. Their similarity was previously noted. The precise molecular and cellular function of members of this family is still unknown. Yet, they are known to be involved in cellular differentiation events. The Ndr1 group was the first to be discovered. Their expression is repressed by the proto-oncogenes N-myc and c-myc, and in line with this observation, Ndr1 protein expression is down-regulated in neoplastic cells, and is reactivated when differentiation is induced by chemicals such as retinoic acid. Ndr2 and Ndr3 expression is not under the control of N-myc or c-myc. Ndr1 expression is also activated by several chemicals: tunicamycin and homocysteine induce Ndr1 in human umbilical endothelial cells; nickel induces Ndr1 in several cell types. Members of this family are found in wide variety of multicellular eukaryotes, including an Ndr1 type protein in Helianthus annuus (sunflower), known as Sf21. Interestingly, the highest scoring matches in the noise are all alpha/beta hydrolases pfam00561, suggesting that this family may have an enzymatic function (Bateman A pers. obs.).","GO:0001818|negative regulation of cytokine production;GO:0007165|signal transduction;GO:0007399|nervous system development;GO:0010574|regulation of vascular endothelial growth factor production;GO:0016055|Wnt signaling pathway;GO:0021762|substantia nigra development;GO:0030154|cell differentiation;GO:0048662|negative regulation of smooth muscle cell proliferation;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0090361|regulation of platelet-derived growth factor production;GO:0099173|postsynapse organization;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0030426|growth cone;GO:0048471|perinuclear region of cytoplasm;GO:0098978|glutamatergic synapse;",".",".","."]
["ENSRNOG00000029535",1123,93.23893977,3806,244.8416477,0.380813234,-1.392844478,{"v":2.8219e-213,"d":"2.82E-213"},{"v":1.1668E-211,"d":"1.17E-211"},"down","yes","Nrbp2","protein_coding","chr7:107799497-107805230:-","gi|564360701|ref|XP_006241947.1|",2528,0,"PREDICTED: nuclear receptor-binding protein 2 isoform X1 [Rattus norvegicus]","gi|672059557|ref|XM_006241885.2|",2647,0,"PREDICTED: Rattus norvegicus nuclear receptor binding protein 2 (Nrbp2), transcript variant X1, mRNA","Q91V36",976,0,"Nuclear receptor-binding protein 2",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006468|protein phosphorylation;GO:0006888|ER to Golgi vesicle-mediated transport;GO:0016242|negative regulation of macroautophagy;GO:0030182|neuron differentiation;GO:0035556|intracellular signal transduction;GO:0043524|negative regulation of neuron apoptotic process;","GO:0005737|cytoplasm;GO:0012505|endomembrane system;","GO:0003674|molecular_function;GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;","K08875","NRBP; nuclear receptor-binding protein"]
["ENSRNOG00000015441",1690,140.3150563,4820,310.0727121,0.452523072,-1.143936744,{"v":9.3167e-199,"d":"9.32E-199"},{"v":3.6547E-197,"d":"3.65E-197"},"down","yes","Il4r","protein_coding","chr1:180115120-180139980:+","gi|158534071|ref|NP_596871.2|",3755,0,"interleukin-4 receptor subunit alpha precursor [Rattus norvegicus]","gi|158534070|ref|NM_133380.2|",3346,0,"Rattus norvegicus interleukin 4 receptor (Il4r), mRNA","Q63257",1451,0,"Interleukin-4 receptor subunit alpha",".",".",".",".","pfam09238","IL4Ra_N","Interleukin-4 receptor alpha chain, N-terminal. Members of this family are related in overall topology to fibronectin type III modules and fold into a sandwich comprising seven antiparallel beta sheets arranged in a three-strand and a four-strand beta-pleated sheet. They are required for binding of interleukin-4 to the receptor alpha chain, which is a crucial event for the generation of a Th2-dominated early immune response.","GO:0002532|production of molecular mediator involved in inflammatory response;GO:0002639|positive regulation of immunoglobulin production;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0016064|immunoglobulin mediated immune response;GO:0019221|cytokine-mediated signaling pathway;GO:0030728|ovulation;GO:0032722|positive regulation of chemokine production;GO:0042127|regulation of cell proliferation;GO:0042832|defense response to protozoan;GO:0043032|positive regulation of macrophage activation;GO:0043306|positive regulation of mast cell degranulation;GO:0043627|response to estrogen;GO:0045626|negative regulation of T-helper 1 cell differentiation;GO:0045630|positive regulation of T-helper 2 cell differentiation;GO:0120162|positive regulation of cold-induced thermogenesis;GO:1901741|positive regulation of myoblast fusion;GO:1990834|response to odorant;","GO:0005615|extracellular space;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0034451|centriolar satellite;GO:0043235|receptor complex;","GO:0003674|molecular_function;GO:0004896|cytokine receptor activity;GO:0044877|protein-containing complex binding;","K05071","IL4R, CD124; interleukin 4 receptor"]
["ENSRNOG00000052498",1834,152.2708954,5053,325.0617041,0.468436895,-1.094073385,{"v":5.6831E-194,"d":"5.68E-194"},{"v":2.1502e-192,"d":"2.15E-192"},"down","yes","Grb14","protein_coding","chr3:49568210-49683889:-","gi|149022123|gb|EDL79017.1|",2843,0,"rCG26210 [Rattus norvegicus]","gi|13928857|ref|NM_031623.1|",1734,0,"Rattus norvegicus growth factor receptor bound protein 14 (Grb14), mRNA","O88900",1096,0,"Growth factor receptor-bound protein 14",".",".",".",".","pfam08947","BPS","BPS (Between PH and SH2). The BPS (Between PH and SH2) domain, comprised of 2 beta strands and a C-terminal helix, is an approximately 45 residue region found in the adaptor proteins Grb7/10/14 that mediates inhibition of the tyrosine kinase domain of the insulin receptor by binding of the N-terminal portion of the BPS domain to the substrate peptide groove of the kinase, acting as a pseudosubstrate inhibitor.","GO:0007165|signal transduction;GO:0008286|insulin receptor signaling pathway;GO:0032869|cellular response to insulin stimulus;GO:0035556|intracellular signal transduction;GO:0046627|negative regulation of insulin receptor signaling pathway;GO:1904145|negative regulation of meiotic cell cycle process involved in oocyte maturation;","GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0010008|endosome membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0005515|protein binding;GO:0030674|protein binding, bridging;GO:0030971|receptor tyrosine kinase binding;GO:0051219|phosphoprotein binding;","K23696","GRB14; growth factor receptor-bound protein 14"]
["ENSRNOG00000009629",102,8.468719374,1221,78.54746502,0.107816584,-3.213348987,{"v":6.1583e-194,"d":"6.16E-194"},{"v":2.3163e-192,"d":"2.32E-192"},"down","yes","Car2","protein_coding","chr2:86741626-86756818:-","gi|9506445|ref|NP_062164.1|",1191,{"v":4e-157,"d":"4.00E-157"},"carbonic anhydrase 2 [Rattus norvegicus]","gi|298916112|emb|FQ213417.1|",723,0,"Rattus norvegicus TL0AAA47YP08 mRNA sequence","P27139",463,{"v":1e-158,"d":"1.00E-158"},"Carbonic anhydrase 2","all2929",114,{"v":3e-27,"d":"3.00E-27"},"COG3338","pfam00194","Carb_anhydrase","Eukaryotic-type carbonic anhydrase.","GO:0001822|kidney development;GO:0002009|morphogenesis of an epithelium;GO:0006730|one-carbon metabolic process;GO:0009268|response to pH;GO:0010033|response to organic substance;GO:0010043|response to zinc ion;GO:0015670|carbon dioxide transport;GO:0030316|osteoclast differentiation;GO:0030641|regulation of cellular pH;GO:0032230|positive regulation of synaptic transmission, GABAergic;GO:0032849|positive regulation of cellular pH reduction;GO:0038166|angiotensin-activated signaling pathway;GO:0042475|odontogenesis of dentin-containing tooth;GO:0043627|response to estrogen;GO:0044070|regulation of anion transport;GO:0045124|regulation of bone resorption;GO:0045672|positive regulation of osteoclast differentiation;GO:0045780|positive regulation of bone resorption;GO:0046903|secretion;GO:0048545|response to steroid hormone;GO:0051453|regulation of intracellular pH;GO:0071498|cellular response to fluid shear stress;GO:2001150|positive regulation of dipeptide transmembrane transport;GO:2001225|regulation of chloride transport;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005902|microvillus;GO:0016323|basolateral plasma membrane;GO:0030424|axon;GO:0043209|myelin sheath;GO:0045177|apical part of cell;","GO:0004064|arylesterase activity;GO:0004089|carbonate dehydratase activity;GO:0005515|protein binding;GO:0008270|zinc ion binding;GO:0016836|hydro-lyase activity;","K18245","CA2; carbonic anhydrase 2 [EC:4.2.1.1]"]
["ENSRNOG00000007808",132,10.95951919,1317,84.72318709,0.129356786,-2.950572355,{"v":3.3875e-193,"d":"3.39E-193"},{"v":1.2593e-191,"d":"1.26E-191"},"down","yes","Nap1l5","protein_coding","chr4:88022569-88024654:-","gi|149033227|gb|EDL88028.1|",836,{"v":3e-104,"d":"3.00E-104"},"rCG52514 [Rattus norvegicus]","gi|112983817|ref|NM_001044293.1|",1606,0,"Rattus norvegicus nucleosome assembly protein 1-like 5 (Nap1l5), mRNA","Q5PPG6",195,{"v":3E-57,"d":"3.00E-57"},"Nucleosome assembly protein 1-like 5",".",".",".",".","pfam00956","NAP","Nucleosome assembly protein (NAP). NAP proteins are involved in moving histones into the nucleus, nucleosome assembly and chromatin fluidity. They affect the transcription of many genes.","GO:0006334|nucleosome assembly;","GO:0000785|chromatin;GO:0005634|nucleus;","GO:0003682|chromatin binding;GO:0042393|histone binding;","K11283","NAP1L5; nucleosome assembly protein 1-like 5"]
["ENSRNOG00000001607",1290,107.1043921,3916,251.9179959,0.42515578,-1.233936543,{"v":2.7681e-182,"d":"2.77E-182"},{"v":9.6718e-181,"d":"9.67E-181"},"down","yes","Adamts1","protein_coding","chr11:24931761-24941103:-","gi|148747506|ref|NP_077376.2|",5000,0,"A disintegrin and metalloproteinase with thrombospondin motifs 1 precursor [Rattus norvegicus]","gi|4929477|gb|AF149118.1|AF149118",4783,0,"Rattus norvegicus a disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS-1) mRNA, complete cds","Q9WUQ1",1927,0,"A disintegrin and metalloproteinase with thrombospondin motifs 1",".",".",".",".","pfam05986","ADAM_spacer1","ADAM-TS Spacer 1. This family represents the Spacer-1 region from the ADAM-TS family of metalloproteinases.","GO:0001542|ovulation from ovarian follicle;GO:0001822|kidney development;GO:0006508|proteolysis;GO:0007229|integrin-mediated signaling pathway;GO:0010976|positive regulation of neuron projection development;GO:0016525|negative regulation of angiogenesis;GO:0030198|extracellular matrix organization;GO:0030728|ovulation;GO:0044691|tooth eruption;GO:0060347|heart trabecula formation;GO:0071305|cellular response to vitamin D;GO:0071374|cellular response to parathyroid hormone stimulus;GO:0071380|cellular response to prostaglandin E stimulus;GO:1900087|positive regulation of G1/S transition of mitotic cell cycle;GO:1904707|positive regulation of vascular smooth muscle cell proliferation;GO:1904754|positive regulation of vascular associated smooth muscle cell migration;","GO:0005576|extracellular region;GO:0005604|basement membrane;GO:0031012|extracellular matrix;GO:0031410|cytoplasmic vesicle;GO:0062023|collagen-containing extracellular matrix;","GO:0003674|molecular_function;GO:0004222|metalloendopeptidase activity;GO:0008201|heparin binding;GO:0008270|zinc ion binding;","K08617","ADAMTS1; a disintegrin and metalloproteinase with thrombospondin motifs 1 [EC:3.4.24.-]"]
["ENSRNOG00000019587",161,13.36729234,1335,85.88113498,0.155648762,-2.683633992,{"v":7.1076e-178,"d":"7.11E-178"},{"v":2.4046e-176,"d":"2.40E-176"},"down","yes","Ptprn","protein_coding","chr9:76741016-76756190:-","gi|564368872|ref|XP_006245196.1|",4282,0,"PREDICTED: receptor-type tyrosine-protein phosphatase-like N isoform X1 [Rattus norvegicus]","gi|672065437|ref|XM_006245134.2|",3515,0,"PREDICTED: Rattus norvegicus protein tyrosine phosphatase, receptor type, N (Ptprn), transcript variant X1, mRNA","Q63259",1647,0,"Receptor-type tyrosine-protein phosphatase-like N","SPAC26F1.10c",135,{"v":4e-32,"d":"4.00E-32"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0000302|response to reactive oxygen species;GO:0001553|luteinization;GO:0009749|response to glucose;GO:0019221|cytokine-mediated signaling pathway;GO:0019932|second-messenger-mediated signaling;GO:0030073|insulin secretion;GO:0032868|response to insulin;GO:0035773|insulin secretion involved in cellular response to glucose stimulus;GO:0043627|response to estrogen;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051591|response to cAMP;GO:1904692|positive regulation of type B pancreatic cell proliferation;GO:1990502|dense core granule maturation;","GO:0005634|nucleus;GO:0005768|endosome;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030141|secretory granule;GO:0030658|transport vesicle membrane;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0043679|axon terminus;GO:0045202|synapse;","GO:0030507|spectrin binding;GO:0044389|ubiquitin-like protein ligase binding;GO:0051020|GTPase binding;","K07817","PTPRN; receptor-type tyrosine-protein phosphatase N [EC:3.1.3.48]"]
["ENSRNOG00000032401",308,25.57221144,1730,111.2916581,0.229776534,-2.121696626,{"v":4.3013e-175,"d":"4.30E-175"},{"v":1.425E-173,"d":"1.43E-173"},"down","yes","H3f3c","protein_coding","chr7:86501071-86502140:+","gi|755472894|ref|XP_006543746.2|",760,{"v":1e-96,"d":"1.00E-96"},"PREDICTED: LOW QUALITY PROTEIN: histone H3.3C isoform X1 [Mus musculus]","gi|672021859|ref|XM_003754308.3|",1050,0,"PREDICTED: Rattus norvegicus H3 histone, family 3C (H3f3c), mRNA","Q6P823",271,{"v":2e-89,"d":"2.00E-89"},"Histone H3.3",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.","GO:0001649|osteoblast differentiation;GO:0006334|nucleosome assembly;GO:0006336|DNA replication-independent nucleosome assembly;GO:0007283|spermatogenesis;GO:0007338|single fertilization;GO:0008150|biological_process;GO:0008283|cell proliferation;GO:0030307|positive regulation of cell growth;GO:0031508|pericentric heterochromatin assembly;GO:0031509|telomeric heterochromatin assembly;GO:0035264|multicellular organism growth;GO:0042692|muscle cell differentiation;GO:0048477|oogenesis;GO:1902340|negative regulation of chromosome condensation;","GO:0000228|nuclear chromosome;GO:0000781|chromosome, telomeric region;GO:0000786|nucleosome;GO:0001740|Barr body;GO:0005575|cellular_component;GO:0005634|nucleus;GO:0032991|protein-containing complex;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000979|RNA polymerase II core promoter sequence-specific DNA binding;GO:0003674|molecular_function;GO:0031492|nucleosomal DNA binding;GO:0046982|protein heterodimerization activity;","K11253","H3; histone H3"]
["ENSRNOG00000021027",1207,100.2131793,3682,236.8646734,0.423081998,-1.240990794,{"v":4.8818e-173,"d":"4.88E-173"},{"v":1.5686E-171,"d":"1.57E-171"},"down","yes","Dbp","protein_coding","chr1:96175440-96180745:+","gi|7549756|ref|NP_036675.1|",1054,{"v":9e-132,"d":"9.00E-132"},"D site-binding protein isoform 1 [Rattus norvegicus]","gi|88023877|gb|AC136191.5|",2150,0,"Rattus norvegicus BAC CH230-52I17 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P16443",406,{"v":9e-132,"d":"9.00E-132"},"D site-binding protein",".",".",".",".","pfam07716","bZIP_2","Basic region leucine zipper.","GO:0001889|liver development;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007623|circadian rhythm;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:1990837|sequence-specific double-stranded DNA binding;","K09056","DBP; albumin D box-binding protein"]
["ENSRNOG00000014456",1328,110.2594052,3918,252.0466568,0.437456329,-1.192789095,{"v":5.6877E-173,"d":"5.69E-173"},{"v":1.8184E-171,"d":"1.82E-171"},"down","yes","Coq10b","protein_coding","chr9:56553758-56573663:+","gi|57528275|ref|NP_001009671.1|",1086,{"v":6e-143,"d":"6.00E-143"},"coenzyme Q-binding protein COQ10 homolog B, mitochondrial [Rattus norvegicus]","gi|57528274|ref|NM_001009671.1|",1600,0,"Rattus norvegicus coenzyme Q10B (Coq10b), mRNA","Q5I0I9",422,{"v":3e-144,"d":"3.00E-144"},"Coenzyme Q-binding protein COQ10 homolog B, mitochondrial","RSc1425",75.9,{"v":4e-15,"d":"4.00E-15"},"COG2867","pfam03364","Polyketide_cyc","Polyketide cyclase / dehydrase and lipid transport. This family contains polyketide cylcases/dehydrases which are enzymes involved in polyketide synthesis. The family also includes proteins which are involved in the binding/transport of lipids.","GO:0006744|ubiquinone biosynthetic process;GO:0045333|cellular respiration;","GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;","GO:0048039|ubiquinone binding;","K18588","COQ10; coenzyme Q-binding protein COQ10"]
["ENSRNOG00000006709",114,9.4650393,1160,74.62330829,0.126837573,-2.97894592,{"v":5.5079e-172,"d":"5.51E-172"},{"v":1.7521E-170,"d":"1.75E-170"},"down","yes","Pzp","protein_coding","chr4:161759182-161805276:-","gi|307746876|ref|NP_665722.2|",7768,0,"alpha-1-macroglobulin precursor [Rattus norvegicus]","gi|307746875|ref|NM_145779.2|",2925,0,"Rattus norvegicus pregnancy-zone protein (Pzp), mRNA","Q63041",2972,0,"Alpha-1-macroglobulin","TM0984",84,{"v":3e-15,"d":"3.00E-15"},"COG2373","pfam07678","A2M_comp","A-macroglobulin complement component. This family includes the complement components region of the alpha-2-macroglobulin family.","GO:0007566|embryo implantation;GO:0010951|negative regulation of endopeptidase activity;","GO:0005615|extracellular space;","GO:0002020|protease binding;GO:0004866|endopeptidase inhibitor activity;GO:0004867|serine-type endopeptidase inhibitor activity;GO:0044877|protein-containing complex binding;GO:0048403|brain-derived neurotrophic factor binding;GO:0048406|nerve growth factor binding;","K23589","PZP; pregnancy zone protein"]
["ENSRNOG00000014117",1763,146.3760025,4706,302.7390421,0.483505535,-1.04839569,{"v":8.486E-169,"d":"8.49E-169"},{"v":2.634e-167,"d":"2.63E-167"},"down","yes","Hmox1","protein_coding","chr19:13467244-13474079:+","gi|6981032|ref|NP_036712.1|",1496,0,"heme oxygenase 1 [Rattus norvegicus]","gi|61098187|ref|NM_012580.2|",1494,0,"Rattus norvegicus heme oxygenase 1 (Hmox1), mRNA","P06762",559,0,"Heme oxygenase 1","sll1184",205,{"v":6e-61,"d":"6.00E-61"},"COG5398","pfam01126","Heme_oxygenase","Heme oxygenase.","GO:0001525|angiogenesis;GO:0001666|response to hypoxia;GO:0002246|wound healing involved in inflammatory response;GO:0006644|phospholipid metabolic process;GO:0006788|heme oxidation;GO:0006879|cellular iron ion homeostasis;GO:0006979|response to oxidative stress;GO:0007264|small GTPase mediated signal transduction;GO:0008217|regulation of blood pressure;GO:0008219|cell death;GO:0008285|negative regulation of cell proliferation;GO:0008630|intrinsic apoptotic signaling pathway in response to DNA damage;GO:0009410|response to xenobiotic stimulus;GO:0010656|negative regulation of muscle cell apoptotic process;GO:0016239|positive regulation of macroautophagy;GO:0016242|negative regulation of macroautophagy;GO:0031670|cellular response to nutrient;GO:0032764|negative regulation of mast cell cytokine production;GO:0034101|erythrocyte homeostasis;GO:0034395|regulation of transcription from RNA polymerase II promoter in response to iron;GO:0034605|cellular response to heat;GO:0035094|response to nicotine;GO:0035556|intracellular signal transduction;GO:0042167|heme catabolic process;GO:0042168|heme metabolic process;GO:0042542|response to hydrogen peroxide;GO:0043065|positive regulation of apoptotic process;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043305|negative regulation of mast cell degranulation;GO:0043392|negative regulation of DNA binding;GO:0043433|negative regulation of DNA-binding transcription factor activity;GO:0043524|negative regulation of neuron apoptotic process;GO:0043619|regulation of transcription from RNA polymerase II promoter in response to oxidative stress;GO:0043627|response to estrogen;GO:0043922|negative regulation by host of viral transcription;GO:0045766|positive regulation of angiogenesis;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0048662|negative regulation of smooth muscle cell proliferation;GO:0051090|regulation of DNA-binding transcription factor activity;GO:0055072|iron ion homeostasis;GO:0071243|cellular response to arsenic-containing substance;GO:0071276|cellular response to cadmium ion;GO:0071456|cellular response to hypoxia;GO:0072719|cellular response to cisplatin;GO:0090050|positive regulation of cell migration involved in sprouting angiogenesis;GO:0097421|liver regeneration;GO:1902042|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1903589|positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:1903901|negative regulation of viral life cycle;GO:1904036|negative regulation of epithelial cell apoptotic process;GO:1904706|negative regulation of vascular smooth muscle cell proliferation;","GO:0005634|nucleus;GO:0005730|nucleolus;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005901|caveola;GO:0048471|perinuclear region of cytoplasm;","GO:0004392|heme oxygenase (decyclizing) activity;GO:0004630|phospholipase D activity;GO:0005198|structural molecule activity;GO:0005515|protein binding;GO:0019899|enzyme binding;GO:0020037|heme binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0046872|metal ion binding;","K00510","HMOX1; heme oxygenase 1 [EC:1.14.14.18]"]
["ENSRNOG00000034038",276,22.9153583,1594,102.5427185,0.223471336,-2.161838301,{"v":2.7189e-165,"d":"2.72E-165"},{"v":8.3985e-164,"d":"8.40E-164"},"down","yes","AABR07005844.1","protein_coding","chr1:185617480-185900277:+","gi|672014845|ref|XP_006223754.2|",3764,0,"PREDICTED: LOW QUALITY PROTEIN: deleted in malignant brain tumors 1 protein-like isoform X6, partial [Rattus norvegicus]","gi|43429891|gb|AY548057.1|",2273,0,"Rattus norvegicus pancrin mRNA, complete cds","Q9UGM3",1397,0,"Deleted in malignant brain tumors 1 protein",".",".",".",".","pfam00530","SRCR","Scavenger receptor cysteine-rich domain. These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.",".",".",".",".","."]
["ENSRNOG00000056457",749,62.18696873,2662,171.2476264,0.363140617,-1.461399791,{"v":7.2581e-161,"d":"7.26E-161"},{"v":2.1586E-159,"d":"2.16E-159"},"down","yes","Gpd1","protein_coding","chr7:130844138-130851529:+","gi|57527919|ref|NP_071551.2|",1666,0,"glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic [Rattus norvegicus]","gi|564400292|ref|XM_006257376.1|",1859,0,"PREDICTED: Rattus norvegicus glycerol-3-phosphate dehydrogenase 1 (soluble) (Gpd1), transcript variant X1, mRNA","O35077",646,0,"Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic","SPBC215.05",326,{"v":2E-99,"d":"2.00E-99"},"COG0240","pfam01210","NAD_Gly3P_dh_N","NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus. NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyses the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain.","GO:0005975|carbohydrate metabolic process;GO:0006072|glycerol-3-phosphate metabolic process;GO:0006094|gluconeogenesis;GO:0006116|NADH oxidation;GO:0006127|glycerophosphate shuttle;GO:0006734|NADH metabolic process;GO:0045821|positive regulation of glycolytic process;GO:0046168|glycerol-3-phosphate catabolic process;GO:0046486|glycerolipid metabolic process;GO:0071320|cellular response to cAMP;GO:0071356|cellular response to tumor necrosis factor;","GO:0005829|cytosol;GO:0009331|glycerol-3-phosphate dehydrogenase complex;","GO:0004367|glycerol-3-phosphate dehydrogenase [NAD+] activity;GO:0004368|glycerol-3-phosphate dehydrogenase (quinone) activity;GO:0042803|protein homodimerization activity;GO:0051287|NAD binding;","K00006","GPD1; glycerol-3-phosphate dehydrogenase (NAD+) [EC:1.1.1.8]"]
["ENSRNOG00000007607",1401,116.3203514,3961,254.8128657,0.456493243,-1.131334589,{"v":7.5667e-161,"d":"7.57E-161"},{"v":2.2399e-159,"d":"2.24E-159"},"down","yes","Nr4a1","protein_coding","chr7:132374840-132389297:+","gi|399498497|ref|NP_077364.2|",2573,0,"nuclear receptor subfamily 4 group A member 1 [Rattus norvegicus]","gi|399498496|ref|NM_024388.2|",2488,0,"Rattus norvegicus nuclear receptor subfamily 4, group A, member 1 (Nr4a1), mRNA","P22829",995,0,"Nuclear receptor subfamily 4 group A member 1",".",".",".",".","pfam00105","zf-C4","Zinc finger, C4 type (two domains). In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.","GO:0001938|positive regulation of endothelial cell proliferation;GO:0001975|response to amphetamine;GO:0002042|cell migration involved in sprouting angiogenesis;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006915|apoptotic process;GO:0014860|neurotransmitter secretion involved in regulation of skeletal muscle contraction;GO:0030522|intracellular receptor signaling pathway;GO:0032496|response to lipopolysaccharide;GO:0035767|endothelial cell chemotaxis;GO:0035914|skeletal muscle cell differentiation;GO:0035924|cellular response to vascular endothelial growth factor stimulus;GO:0043065|positive regulation of apoptotic process;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0045444|fat cell differentiation;GO:0045786|negative regulation of cell cycle;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051602|response to electrical stimulus;GO:0061469|regulation of type B pancreatic cell proliferation;GO:0071310|cellular response to organic substance;GO:0071376|cellular response to corticotropin-releasing hormone stimulus;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;GO:0031965|nuclear membrane;GO:0098793|presynapse;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0004879|nuclear receptor activity;GO:0005515|protein binding;GO:0008270|zinc ion binding;GO:0035259|glucocorticoid receptor binding;GO:0042802|identical protein binding;GO:0043565|sequence-specific DNA binding;GO:0046982|protein heterodimerization activity;GO:1990837|sequence-specific double-stranded DNA binding;","K04465","NR4A1, HMR; nuclear receptor subfamily 4 group A member 1"]
["ENSRNOG00000011923",185,15.3599322,1318,84.78751753,0.181157942,-2.464680038,{"v":5.2121e-160,"d":"5.21E-160"},{"v":1.5287E-158,"d":"1.53E-158"},"down","yes","Mgarp","protein_coding","chr2:135431283-135439612:-","gi|157818123|ref|NP_001103026.1|",744,{"v":8e-93,"d":"8.00E-93"},"protein MGARP [Rattus norvegicus]","gi|157818122|ref|NM_001109556.1|",1161,0,"Rattus norvegicus mitochondria-localized glutamic acid-rich protein (Mgarp), mRNA","Q8VI64",207,{"v":8e-62,"d":"8.00E-62"},"Protein MGARP",".",".",".",".","pfam14962","AIF-MLS","Mitochondria Localisation Sequence. This family contains a protein found in eukaryotes. Proteins in this family are typically between 240 and 613 amino acids in length. The family is found in association with pfam07992. This protein family is an N-terminal domain for the mitochondrial localisation sequence for an apoptosis-inducing factor. The protein is also known as Corneal endothelium-specific protein 1 or as Ovary-specific acidic protein. It is thought to be important for membrane function and is expressed in the ovary and corneal endothelium.","GO:0006626|protein targeting to mitochondrion;GO:0008089|anterograde axonal transport;GO:0008090|retrograde axonal transport;GO:0010822|positive regulation of mitochondrion organization;GO:0019896|axonal transport of mitochondrion;GO:0071383|cellular response to steroid hormone stimulus;GO:0071456|cellular response to hypoxia;GO:0097211|cellular response to gonadotropin-releasing hormone;","GO:0005739|mitochondrion;GO:0031307|integral component of mitochondrial outer membrane;GO:1904115|axon cytoplasm;",".",".","."]
["ENSRNOG00000004303",842,69.90844816,2847,183.1487575,0.381703098,-1.389477198,{"v":1.7944e-159,"d":"1.79E-159"},{"v":5.2152e-158,"d":"5.22E-158"},"down","yes","Timp3","protein_coding","chr7:17521919-17571839:-","gi|67972654|ref|NP_037018.2|",1030,{"v":2e-134,"d":"2.00E-134"},"metalloproteinase inhibitor 3 precursor [Rattus norvegicus]","gi|67972653|ref|NM_012886.2|",1743,0,"Rattus norvegicus TIMP metallopeptidase inhibitor 3 (Timp3), mRNA","P39876",400,{"v":3e-135,"d":"3.00E-135"},"Metalloproteinase inhibitor 3",".",".",".",".","pfam00965","TIMP","Tissue inhibitor of metalloproteinase. Members of this family are common in extracellular regions of vertebrate species","GO:0007417|central nervous system development;GO:0007568|aging;GO:0009612|response to mechanical stimulus;GO:0009725|response to hormone;GO:0010033|response to organic substance;GO:0010951|negative regulation of endopeptidase activity;GO:0014070|response to organic cyclic compound;GO:0034097|response to cytokine;GO:0042246|tissue regeneration;GO:0043200|response to amino acid;GO:0043627|response to estrogen;GO:0045861|negative regulation of proteolysis;GO:0051045|negative regulation of membrane protein ectodomain proteolysis;GO:0051593|response to folic acid;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0071310|cellular response to organic substance;GO:1903984|positive regulation of TRAIL-activated apoptotic signaling pathway;GO:1904684|negative regulation of metalloendopeptidase activity;","GO:0005576|extracellular region;GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0031012|extracellular matrix;","GO:0002020|protease binding;GO:0003674|molecular_function;GO:0008191|metalloendopeptidase inhibitor activity;GO:0008270|zinc ion binding;GO:0046872|metal ion binding;","K16866","TIMP3; metalloproteinase inhibitor 3"]
["ENSRNOG00000001295",892,74.05978119,2924,188.1022013,0.39372097,-1.34475454,{"v":7.4247e-156,"d":"7.42E-156"},{"v":2.11e-154,"d":"2.11E-154"},"down","yes","S100b","protein_coding","chr20:12372881-12394743:-","gi|149043704|gb|EDL97155.1|",313,{"v":3e-36,"d":"3.00E-36"},"S100 protein, beta polypeptide, isoform CRA_a [Rattus norvegicus]","gi|672086144|ref|XM_008772868.1|",1484,0,"PREDICTED: Rattus norvegicus S100 calcium binding protein B (S100b), transcript variant X1, mRNA","P04631",139,{"v":1e-37,"d":"1.00E-37"},"Protein S100-B",".",".",".",".","pfam01023","S_100","S-100/ICaBP type calcium binding domain. The S-100 domain is a subfamily of the EF-hand calcium binding proteins.","GO:0007611|learning or memory;GO:0007613|memory;GO:0008284|positive regulation of cell proliferation;GO:0008360|regulation of cell shape;GO:0031643|positive regulation of myelination;GO:0043065|positive regulation of apoptotic process;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0048168|regulation of neuronal synaptic plasticity;GO:0048708|astrocyte differentiation;GO:0050806|positive regulation of synaptic transmission;GO:0051384|response to glucocorticoid;GO:0051597|response to methylmercury;GO:0060291|long-term synaptic potentiation;GO:0071456|cellular response to hypoxia;GO:2001015|negative regulation of skeletal muscle cell differentiation;","GO:0001726|ruffle;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0043025|neuronal cell body;GO:0043231|intracellular membrane-bounded organelle;GO:0048471|perinuclear region of cytoplasm;","GO:0005102|signaling receptor binding;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0008270|zinc ion binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0044548|S100 protein binding;GO:0048156|tau protein binding;GO:0048306|calcium-dependent protein binding;GO:0050786|RAGE receptor binding;","K23770","S100B; protein S100-B"]
["ENSRNOG00000036816",1729,143.553096,4529,291.3525545,0.492712673,-1.021181514,{"v":9.5989e-156,"d":"9.60E-156"},{"v":2.7158e-154,"d":"2.72E-154"},"down","yes","Wls","protein_coding","chr2:248931903-249048298:+","gi|148679892|gb|EDL11839.1|",2839,0,"G protein-coupled receptor 177, isoform CRA_a, partial [Mus musculus]","gi|54262192|ref|NM_199408.2|",2865,0,"Rattus norvegicus wntless Wnt ligand secretion mediator (Wls), transcript variant 1, mRNA","Q6P689",1095,0,"Protein wntless homolog",".",".",".",".","pfam06664","MIG-14_Wnt-bd","Wnt-binding factor required for Wnt secretion. MIG-14 is a Wnt-binding factor. Newly synthesized EGL-20/Wnt binds to MIG-14 in the Golgi, targetting the Wnt to the cell membrane for secretion. AP-2-mediated endocytosis and retromer retrieval at the sorting endosome would recycle MIG-14 to the Golgi, where it can bind to EGL-20/Wnt for next cycle of secretion.","GO:0001707|mesoderm formation;GO:0006886|intracellular protein transport;GO:0008150|biological_process;GO:0009948|anterior/posterior axis specification;GO:0016055|Wnt signaling pathway;GO:0030177|positive regulation of Wnt signaling pathway;GO:0030901|midbrain development;GO:0030902|hindbrain development;GO:0031017|exocrine pancreas development;GO:0061355|Wnt protein secretion;GO:0061357|positive regulation of Wnt protein secretion;GO:0090263|positive regulation of canonical Wnt signaling pathway;","GO:0000139|Golgi membrane;GO:0005769|early endosome;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005794|Golgi apparatus;GO:0005802|trans-Golgi network;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0012505|endomembrane system;GO:0016021|integral component of membrane;GO:0031301|integral component of organelle membrane;GO:0031410|cytoplasmic vesicle;GO:0031901|early endosome membrane;GO:0032590|dendrite membrane;GO:0032839|dendrite cytoplasm;","GO:0005515|protein binding;GO:0017147|Wnt-protein binding;GO:0031852|mu-type opioid receptor binding;GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000007907",774,64.26263525,2675,172.0839221,0.373437765,-1.421060264,{"v":4.465e-155,"d":"4.47E-155"},{"v":1.2577e-153,"d":"1.26E-153"},"down","yes","Tmem178a","protein_coding","chr6:14004630-14063549:-","gi|51948534|ref|NP_001004282.1|",1323,{"v":2e-177,"d":"2.00E-177"},"transmembrane protein 178A precursor [Rattus norvegicus]","gi|51260761|gb|BC079338.1|",1671,0,"Rattus norvegicus transmembrane protein 178, mRNA (cDNA clone MGC:94782 IMAGE:7106500), complete cds","Q68FV0",514,{"v":5e-179,"d":"5.00E-179"},"Transmembrane protein 178A",".",".",".",".","pfam13903","Claudin_2","PMP-22/EMP/MP20/Claudin tight junction. Members of this family are claudins, that form tight junctions between cells.","GO:0045671|negative regulation of osteoclast differentiation;GO:0051480|regulation of cytosolic calcium ion concentration;","GO:0005789|endoplasmic reticulum membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000000195",1393,115.6561381,3879,249.5377697,0.463481493,-1.109416362,{"v":9.8721e-153,"d":"9.87E-153"},{"v":2.7445e-151,"d":"2.74E-151"},"down","yes","Vwa5a","protein_coding","chr8:38815210-38839112:+","gi|564344233|ref|XP_006235566.1|",4171,0,"PREDICTED: von Willebrand factor A domain-containing protein 5A isoform X6 [Rattus norvegicus]","gi|672047906|ref|XM_006242841.2|",3849,0,"PREDICTED: Rattus norvegicus von Willebrand factor A domain containing 5A (Vwa5a), transcript variant X4, mRNA",".",".",".",".","alr4412",127,{"v":7e-29,"d":"7.00E-29"},"COG2304","pfam13768","VWA_3","von Willebrand factor type A domain.",".","GO:0005654|nucleoplasm;",".",".","."]
["ENSRNOG00000033402",402,33.37671753,1820,117.0813975,0.285072763,-1.810597888,{"v":1.0234e-149,"d":"1.02E-149"},{"v":2.7847E-148,"d":"2.78E-148"},"down","yes","Gsta6","protein_coding","chr9:23744288-23801131:-","gi|66730521|ref|NP_001019532.1|",1180,{"v":3E-160,"d":"3.00E-160"},"glutathione S-transferase A6 [Rattus norvegicus]","gi|672064615|ref|XM_006244656.2|",1062,0,"PREDICTED: Rattus norvegicus similar to Glutathione S-transferase A1 (GTH1) (HA subunit 1) (GST-epsilon) (GSTA1-1) (GST class-alpha) (LOC501110), transcript variant X1, mRNA","Q6AXY0",459,{"v":9e-162,"d":"9.00E-162"},"Glutathione S-transferase A6",".",".",".",".","pfam00043","GST_C","Glutathione S-transferase, C-terminal domain. GST conjugates reduced glutathione to a variety of targets including S-crystallin from squid, the eukaryotic elongation factor 1-gamma, the HSP26 family of stress-related proteins and auxin-regulated proteins in plants. Stringent starvation proteins in Escherichia coli are also included in the alignment but are not known to have GST activity.     The glutathione molecule binds in a cleft between N and C-terminal domains. The catalytically important residues are proposed to reside in the N-terminal domain. In plants, GSTs are encoded by a large gene family (48 GST genes in Arabidopsis) and can be divided into the phi, tau, theta, zeta, and lambda classes.","GO:0006749|glutathione metabolic process;GO:0006805|xenobiotic metabolic process;GO:0009617|response to bacterium;GO:0035634|response to stilbenoid;","GO:0005829|cytosol;","GO:0004364|glutathione transferase activity;","K00799","GST, gst; glutathione S-transferase [EC:2.5.1.18]"]
["ENSRNOG00000016977",567,47.07611652,2173,139.7900422,0.336763018,-1.570194378,{"v":3.6042e-146,"d":"3.60E-146"},{"v":9.6022e-145,"d":"9.60E-145"},"down","yes","Calb2","protein_coding","chr19:38114424-38141438:-","gi|672084703|ref|XP_008770688.1|",1282,{"v":4e-171,"d":"4.00E-171"},"PREDICTED: calretinin isoform X1 [Rattus norvegicus]","gi|672084702|ref|XM_008772466.1|",1304,0,"PREDICTED: Rattus norvegicus calbindin 2 (Calb2), transcript variant X1, mRNA","P47728",494,{"v":3e-172,"d":"3.00E-172"},"Calretinin",".",".",".",".","pfam13499","EF-hand_7","EF-hand domain pair.","GO:0008150|biological_process;GO:0051480|regulation of cytosolic calcium ion concentration;GO:0099509|regulation of presynaptic cytosolic calcium ion concentration;GO:1900271|regulation of long-term synaptic potentiation;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005921|gap junction;GO:0030425|dendrite;GO:0032420|stereocilium;GO:0032437|cuticular plate;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0045202|synapse;GO:0097060|synaptic membrane;GO:0098688|parallel fiber to Purkinje cell synapse;GO:0099096|vestibular calyx terminal;","GO:0005509|calcium ion binding;GO:0099534|calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration;","K23908","CALB2; calretinin"]
["ENSRNOG00000011951",405,33.62579751,1806,116.1807714,0.28942653,-1.788730924,{"v":3.773E-146,"d":"3.77E-146"},{"v":1.001E-144,"d":"1.00E-144"},"down","yes","Plk2","protein_coding","chr2:41969176-41974947:+","gi|625183267|ref|XP_003496249.2|",3420,0,"PREDICTED: serine/threonine-protein kinase PLK2 [Cricetulus griseus]","gi|47481733|gb|BC070878.1|",2708,0,"Rattus norvegicus polo-like kinase 2 (Drosophila), mRNA (cDNA clone MGC:91616 IMAGE:7096750), complete cds","Q9R012",1313,0,"Serine/threonine-protein kinase PLK2",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0000082|G1/S transition of mitotic cell cycle;GO:0000278|mitotic cell cycle;GO:0006468|protein phosphorylation;GO:0007052|mitotic spindle organization;GO:0007265|Ras protein signal transduction;GO:0007613|memory;GO:0010508|positive regulation of autophagy;GO:0016525|negative regulation of angiogenesis;GO:0018105|peptidyl-serine phosphorylation;GO:0032092|positive regulation of protein binding;GO:0032436|positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032465|regulation of cytokinesis;GO:0032486|Rap protein signal transduction;GO:0043066|negative regulation of apoptotic process;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045732|positive regulation of protein catabolic process;GO:0046599|regulation of centriole replication;GO:0048167|regulation of synaptic plasticity;GO:0060291|long-term synaptic potentiation;GO:0060292|long-term synaptic depression;GO:0061000|negative regulation of dendritic spine development;GO:0071866|negative regulation of apoptotic process in bone marrow;GO:0090050|positive regulation of cell migration involved in sprouting angiogenesis;GO:2000773|negative regulation of cellular senescence;","GO:0000785|chromatin;GO:0000922|spindle pole;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0005814|centriole;GO:0030425|dendrite;","GO:0004674|protein serine/threonine kinase activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0043008|ATP-dependent protein binding;GO:0044877|protein-containing complex binding;","K08861","PLK2; polo-like kinase 2 [EC:2.7.11.21]"]
["ENSRNOG00000020139",1136,94.31828636,3308,212.8050895,0.44321443,-1.173923243,{"v":9.643e-143,"d":"9.64E-143"},{"v":2.5167e-141,"d":"2.52E-141"},"down","yes","ENSRNOG00000020139","protein_coding","chr2:174149141-174177504:+","gi|109466882|ref|XP_001070697.1|",2334,0,"PREDICTED: UPF0469 protein KIAA0907 homolog [Rattus norvegicus]","gi|564300541|ref|XM_001070697.4|",2916,0,"PREDICTED: Rattus norvegicus similar to RIKEN cDNA 2810403A07 (RGD1565775), mRNA","Q3TCX3",887,0,"KH homology domain-containing protein 4",".",".",".",".","pfam11751","DUF3308","Protein of unknown function (DUF3308). Some members of this family of bacterial proteins are annotated as being one of the several TonB-dependent siderophore receptors, but this could not be confirmed.","GO:0006376|mRNA splice site selection;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005681|spliceosomal complex;GO:0005737|cytoplasm;","GO:0003723|RNA binding;",".","."]
["ENSRNOG00000007682",907,75.3051811,2841,182.7627749,0.412037851,-1.279151219,{"v":2.2651e-140,"d":"2.27E-140"},{"v":5.8399e-139,"d":"5.84E-139"},"down","yes","ENSRNOG00000007682","protein_coding","chrX:120238534-120504096:+","gi|60360568|dbj|BAD90527.1|",4554,0,"mKIAA4184 protein [Mus musculus]","gi|163792202|ref|NM_032990.2|",5024,0,"Rattus norvegicus glutamate ionotropic receptor AMPA type subunit 3 (Gria3), transcript variant 1, mRNA","Q9Z2W9",1725,0,"Glutamate receptor 3",".",".",".",".","pfam00060","Lig_chan","Ligand-gated ion channel. This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.","GO:0001919|regulation of receptor recycling;GO:0010226|response to lithium ion;GO:0034220|ion transmembrane transport;GO:0035235|ionotropic glutamate receptor signaling pathway;GO:0060078|regulation of postsynaptic membrane potential;GO:0060992|response to fungicide;","GO:0005886|plasma membrane;GO:0008328|ionotropic glutamate receptor complex;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0032279|asymmetric synapse;GO:0032281|AMPA glutamate receptor complex;GO:0032991|protein-containing complex;GO:0043025|neuronal cell body;GO:0043083|synaptic cleft;GO:0043195|terminal bouton;GO:0043197|dendritic spine;GO:0043198|dendritic shaft;GO:0043204|perikaryon;GO:0045211|postsynaptic membrane;GO:0098688|parallel fiber to Purkinje cell synapse;GO:0098978|glutamatergic synapse;GO:0099055|integral component of postsynaptic membrane;GO:0099056|integral component of presynaptic membrane;GO:0099061|integral component of postsynaptic density membrane;","GO:0001540|amyloid-beta binding;GO:0004970|ionotropic glutamate receptor activity;GO:0004971|AMPA glutamate receptor activity;GO:0005515|protein binding;GO:0015276|ligand-gated ion channel activity;GO:0030165|PDZ domain binding;GO:0038023|signaling receptor activity;GO:1904315|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K05199","GRIA3; glutamate receptor 3"]
["ENSRNOG00000007830",362,30.05565111,1657,106.5955361,0.281959754,-1.826438844,{"v":4.2159e-138,"d":"4.22E-138"},{"v":1.0655e-136,"d":"1.07E-136"},"down","yes","Apold1","protein_coding","chr4:167818271-167825706:+","gi|50979282|ref|NP_001003403.1|",890,{"v":4e-108,"d":"4.00E-108"},"apolipoprotein L domain-containing protein 1 [Rattus norvegicus]","gi|50979281|ref|NM_001003403.1|",2883,0,"Rattus norvegicus apolipoprotein L domain containing 1 (Apold1), mRNA","Q6B959",345,{"v":7e-109,"d":"7.00E-109"},"Apolipoprotein L domain-containing protein 1",".",".",".",".","pfam10070","DUF2309","Uncharacterized protein conserved in bacteria (DUF2309). Members of this family of hypothetical bacterial proteins have no known function.","GO:0001525|angiogenesis;GO:0001666|response to hypoxia;GO:0006869|lipid transport;GO:0030154|cell differentiation;GO:0042118|endothelial cell activation;GO:0042157|lipoprotein metabolic process;GO:0045601|regulation of endothelial cell differentiation;","GO:0005576|extracellular region;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0008289|lipid binding;",".","."]
["ENSRNOG00000069423",489,40.600037,1937,124.6080588,0.32582192,-1.617844427,{"v":3.3991e-136,"d":"3.40E-136"},{"v":8.5233e-135,"d":"8.52E-135"},"down","yes","ENSRNOG00000069423","protein_coding","chr8:2791853-2797967:+","gi|852749799|ref|XP_012872059.1|",906,{"v":6e-110,"d":"6.00E-110"},"PREDICTED: endogenous retrovirus group K member 8 Pol protein-like [Dipodomys ordii]","gi|153791782|ref|NG_006339.2|",1765,0,"Rattus norvegicus vomeronasal 2 receptor, pseudogene 55 (Vom2r-ps55) on chromosome 1","P04026",298,{"v":3e-91,"d":"3.00E-91"},"Intracisternal A-particle Pol-related polyprotein (Fragment)",".",".",".",".","pfam00665","rve","Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyses the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.",".",".",".",".","."]
["ENSRNOG00000028711",1050,87.17799355,3089,198.7167236,0.438704866,-1.188677387,{"v":4.631e-136,"d":"4.63E-136"},{"v":1.1522e-134,"d":"1.15E-134"},"down","yes","Dgat1","protein_coding","chr7:108218524-108234299:-","gi|26453324|dbj|BAC43739.1|",2221,0,"diacylglycerol acyltransferase [Rattus norvegicus]","gi|26453331|dbj|AB062763.1|",1457,0,"Rattus norvegicus DGAT mRNA for diacylglycerol acyltransferase, complete cds, strain:Sprague-Dawley","Q9ERM3",842,0,"Diacylglycerol O-acyltransferase 1","ECU10g0300",138,{"v":5e-34,"d":"5.00E-34"},"COG5056","pfam03062","MBOAT","MBOAT, membrane-bound O-acyltransferase family. The MBOAT (membrane bound O-acyl transferase) family of membrane proteins contains a variety of acyltransferase enzymes. A conserved histidine has been suggested to be the active site residue.","GO:0006640|monoacylglycerol biosynthetic process;GO:0010867|positive regulation of triglyceride biosynthetic process;GO:0019432|triglyceride biosynthetic process;GO:0019915|lipid storage;GO:0030073|insulin secretion;GO:0034379|very-low-density lipoprotein particle assembly;GO:0035336|long-chain fatty-acyl-CoA metabolic process;GO:0042572|retinol metabolic process;GO:0044752|response to human chorionic gonadotropin;GO:0046321|positive regulation of fatty acid oxidation;GO:0046339|diacylglycerol metabolic process;GO:0046486|glycerolipid metabolic process;GO:0055089|fatty acid homeostasis;GO:1901738|regulation of vitamin A metabolic process;GO:1902224|ketone body metabolic process;GO:1903998|regulation of eating behavior;GO:1904729|regulation of intestinal lipid absorption;GO:2000491|positive regulation of hepatic stellate cell activation;","GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0003846|2-acylglycerol O-acyltransferase activity;GO:0004144|diacylglycerol O-acyltransferase activity;GO:0005504|fatty acid binding;GO:0008374|O-acyltransferase activity;GO:0016746|transferase activity, transferring acyl groups;GO:0019992|diacylglycerol binding;GO:0042802|identical protein binding;GO:0050252|retinol O-fatty-acyltransferase activity;","K11155","DGAT1; diacylglycerol O-acyltransferase 1 [EC:2.3.1.20 2.3.1.75 2.3.1.76]"]
["ENSRNOG00000058436",13,1.079346587,617,39.69188036,0.027193133,-5.200613805,{"v":1.3486E-129,"d":"1.35E-129"},{"v":3.2175e-128,"d":"3.22E-128"},"down","yes","ENSRNOG00000058436","protein_coding","chr1:61427039-61448888:+","gi|564296543|ref|XP_006223014.1|",4101,0,"PREDICTED: zinc finger protein 52 isoform X1 [Rattus norvegicus]","gi|672034453|ref|XM_008758764.1|",2537,0,"PREDICTED: Rattus norvegicus zinc finger protein 52 (Zfp52), transcript variant X5, mRNA","Q8TAQ5",660,0,"Zinc finger protein 420",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0045944|positive regulation of transcription by RNA polymerase II;",".","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0046872|metal ion binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSRNOG00000027433",278,23.08141163,1375,88.4543525,0.260941502,-1.938201674,{"v":2.3819e-124,"d":"2.38E-124"},{"v":5.3816e-123,"d":"5.38E-123"},"down","yes","Akr1b8","protein_coding","chr4:62997161-63010097:+","gi|149065228|gb|EDM15304.1|",1536,0,"rCG27994 [Rattus norvegicus]","gi|51480423|gb|BC080239.1|",2994,0,"Rattus norvegicus aldo-keto reductase family 1, member B8, mRNA (cDNA clone IMAGE:7100613), with apparent retained intron","P45377",567,0,"Aldose reductase-related protein 2","slr0942",223,{"v":4e-64,"d":"4.00E-64"},"COG0656","pfam00248","Aldo_ket_red","Aldo/keto reductase family. This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.",".",".",".",".","."]
["ENSRNOG00000067040",300,24.90799816,1424,91.60654398,0.271901952,-1.878841584,{"v":1.5282e-123,"d":"1.53E-123"},{"v":3.4048e-122,"d":"3.40E-122"},"down","yes","ENSRNOG00000067040","protein_coding","chr3:138654777-138675861:-","gi|889029083|ref|NP_001297574.1|",1844,0,"zinc finger protein 442 [Mus musculus]","gi|23274125|gb|BC023805.1|",841,0,"Mus musculus zinc finger protein 442, mRNA (cDNA clone MGC:38507 IMAGE:5352880), complete cds","Q8BZW4",540,{"v":1E-175,"d":"1.00E-175"},"Zinc finger protein 120",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000071035",555,46.07979659,1994,128.2748937,0.359226932,-1.477032577,{"v":6.6776e-123,"d":"6.68E-123"},{"v":1.4825E-121,"d":"1.48E-121"},"down","yes","ENSRNOG00000071035","lncRNA","chr14:2664232-2665383:+",".",".",".",".","gi|229577251|ref|NM_011578.3|",847,0,"Mus musculus transforming growth factor, beta receptor III (Tgfbr3), mRNA",".",".",".",".",".",".",".",".","pfam09423","PhoD","PhoD-like phosphatase.",".",".",".",".","."]
["ENSRNOG00000020384",1410,117.0675913,3648,234.6774385,0.498844678,-1.003337411,{"v":2.7609e-122,"d":"2.76E-122"},{"v":6.0875e-121,"d":"6.09E-121"},"down","yes","Fam13b","protein_coding","chr18:26040285-26106587:-","gi|672083019|ref|XP_008770252.1|",4014,0,"PREDICTED: protein FAM13B isoform X1 [Rattus norvegicus]","gi|672083018|ref|XM_008772030.1|",4719,0,"PREDICTED: Rattus norvegicus family with sequence similarity 13, member B (Fam13b), transcript variant X1, mRNA","Q8K2H3",1435,0,"Protein FAM13B",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0007165|signal transduction;",".",".",".","."]
["ENSRNOG00000047581",7,0.581186624,553,35.57473232,0.016337062,-5.935707592,{"v":1.8097e-117,"d":"1.81E-117"},{"v":3.8315e-116,"d":"3.83E-116"},"down","yes","AABR07066700.1","protein_coding","chr9:2849456-2916360:-","gi|672033554|ref|XP_008756458.1|",724,{"v":9e-112,"d":"9.00E-112"},"PREDICTED: uncharacterized protein LOC102557335 [Rattus norvegicus]","gi|672033553|ref|XM_008758236.1|",1256,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102557335 (LOC102557335), mRNA",".",".",".",".",".",".",".",".","pfam04822","Takusan","Takusan. This domain is named takusan, which is a Japanese word meaning 'many'. Members of this family regulate synaptic activity.",".",".",".",".","."]
["ENSRNOG00000015279",339,28.14603792,1479,95.14471808,0.295823441,-1.757191718,{"v":3.5764e-117,"d":"3.58E-117"},{"v":7.5222e-116,"d":"7.52E-116"},"down","yes","Vtcn1","protein_coding","chr2:188253594-188321658:+","gi|66730411|ref|NP_001019415.1|",1294,{"v":4e-169,"d":"4.00E-169"},"V-set domain-containing T-cell activation inhibitor 1 precursor [Rattus norvegicus]","gi|66730410|ref|NM_001024244.1|",2619,0,"Rattus norvegicus V-set domain containing T cell activation inhibitor 1 (Vtcn1), mRNA","Q501W4",503,{"v":1e-170,"d":"1.00E-170"},"V-set domain-containing T-cell activation inhibitor 1",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0001562|response to protozoan;GO:0001817|regulation of cytokine production;GO:0002250|adaptive immune response;GO:0032743|positive regulation of interleukin-2 production;GO:0042102|positive regulation of T cell proliferation;GO:0042130|negative regulation of T cell proliferation;GO:0043066|negative regulation of apoptotic process;GO:0050852|T cell receptor signaling pathway;GO:0050868|negative regulation of T cell activation;","GO:0009897|external side of plasma membrane;GO:0031225|anchored component of membrane;","GO:0005102|signaling receptor binding;","K06747","B7H4, VTCN1; immune costimulatory protein B7-H4"]
["ENSRNOG00000010797",159,13.20123902,1028,66.13169045,0.199620468,-2.324668438,{"v":4.334e-117,"d":"4.33E-117"},{"v":9.0268e-116,"d":"9.03E-116"},"down","yes","Esm1","protein_coding","chr2:44876067-44884804:+","gi|12018274|ref|NP_072126.1|",889,{"v":4e-112,"d":"4.00E-112"},"endothelial cell-specific molecule 1 precursor [Rattus norvegicus]","gi|47575857|ref|NM_022604.2|",2084,0,"Rattus norvegicus endothelial cell-specific molecule 1 (Esm1), mRNA","P97682",347,{"v":1e-113,"d":"1.00E-113"},"Endothelial cell-specific molecule 1",".",".",".",".","pfam00219","IGFBP","Insulin-like growth factor binding protein.","GO:0001525|angiogenesis;GO:0002040|sprouting angiogenesis;GO:0008284|positive regulation of cell proliferation;GO:1902204|positive regulation of hepatocyte growth factor receptor signaling pathway;","GO:0005576|extracellular region;","GO:0005171|hepatocyte growth factor receptor binding;GO:0005178|integrin binding;GO:0005520|insulin-like growth factor binding;","K25036","ESM1; endothelial cell-specific molecule 1"]
["ENSRNOG00000048043",928,77.04874097,2697,173.4991918,0.444087031,-1.171085655,{"v":2.6681e-116,"d":"2.67E-116"},{"v":5.5034E-115,"d":"5.50E-115"},"down","yes","F2r","protein_coding","chr2:26868404-26885870:-","gi|82617583|ref|NP_037082.2|",2065,0,"proteinase-activated receptor 1 precursor [Rattus norvegicus]","gi|82617582|ref|NM_012950.2|",3002,0,"Rattus norvegicus coagulation factor II (thrombin) receptor (F2r), mRNA","P26824",795,0,"Proteinase-activated receptor 1",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0002248|connective tissue replacement involved in inflammatory response wound healing;GO:0003105|negative regulation of glomerular filtration;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006954|inflammatory response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007205|protein kinase C-activating G protein-coupled receptor signaling pathway;GO:0007529|establishment of synaptic specificity at neuromuscular junction;GO:0007596|blood coagulation;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0009611|response to wounding;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0030168|platelet activation;GO:0030193|regulation of blood coagulation;GO:0030194|positive regulation of blood coagulation;GO:0030335|positive regulation of cell migration;GO:0032496|response to lipopolysaccharide;GO:0032651|regulation of interleukin-1 beta production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0032967|positive regulation of collagen biosynthetic process;GO:0035025|positive regulation of Rho protein signal transduction;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043280|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043410|positive regulation of MAPK cascade;GO:0043524|negative regulation of neuron apoptotic process;GO:0043547|positive regulation of GTPase activity;GO:0045217|cell-cell junction maintenance;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045907|positive regulation of vasoconstriction;GO:0045987|positive regulation of smooth muscle contraction;GO:0046427|positive regulation of JAK-STAT cascade;GO:0048873|homeostasis of number of cells within a tissue;GO:0051209|release of sequestered calcium ion into cytosol;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;GO:0051482|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway;GO:0051928|positive regulation of calcium ion transport;GO:0051930|regulation of sensory perception of pain;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070493|thrombin-activated receptor signaling pathway;GO:0099553|trans-synaptic signaling by endocannabinoid, modulating synaptic transmission;GO:1900134|negative regulation of renin secretion into blood stream;","GO:0005769|early endosome;GO:0005770|late endosome;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005901|caveola;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0031094|platelet dense tubular network;GO:0031594|neuromuscular junction;GO:0045202|synapse;GO:0045211|postsynaptic membrane;","GO:0001965|G-protein alpha-subunit binding;GO:0004930|G protein-coupled receptor activity;GO:0005102|signaling receptor binding;GO:0015057|thrombin-activated receptor activity;GO:0031681|G-protein beta-subunit binding;","K03914","F2R, PAR1; coagulation factor II (thrombin) receptor"]
["ENSRNOG00000038746",681,56.54115582,2209,142.105938,0.397880318,-1.329593559,{"v":3.1882e-116,"d":"3.19E-116"},{"v":6.5548e-115,"d":"6.55E-115"},"down","yes","Bco2","protein_coding","chr8:50882181-50915467:-","gi|189181706|ref|NP_001121184.1|",2800,0,"beta,beta-carotene 9',10'-oxygenase [Rattus norvegicus]","gi|189181705|ref|NM_001127712.1|",2509,0,"Rattus norvegicus beta-carotene oxygenase 2 (Bco2), mRNA","Q99NF1",1017,0,"Beta,beta-carotene 9',10'-oxygenase","all1106",94,{"v":3e-19,"d":"3.00E-19"},"COG3670","pfam03055","RPE65","Retinal pigment epithelial membrane protein. This family represents a retinal pigment epithelial membrane receptor which is abundantly expressed in retinal pigment epithelium, and binds plasma retinal binding protein. The family also includes the sequence related neoxanthin cleavage enzyme in plants and lignostilbene-alpha,beta-dioxygenase in bacteria.","GO:0006412|translation;GO:0016116|carotenoid metabolic process;GO:0016119|carotene metabolic process;GO:0016121|carotene catabolic process;GO:0016122|xanthophyll metabolic process;GO:0042574|retinal metabolic process;GO:0051881|regulation of mitochondrial membrane potential;GO:2000377|regulation of reactive oxygen species metabolic process;","GO:0005739|mitochondrion;GO:0005840|ribosome;","GO:0003735|structural constituent of ribosome;GO:0003834|beta-carotene 15,15'-monooxygenase activity;GO:0010436|carotenoid dioxygenase activity;GO:0016702|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;GO:0046872|metal ion binding;","K10252","BCDO2; beta,beta-carotene 9',10'-dioxygenase [EC:1.13.11.71]"]
["ENSRNOG00000033192",258,21.42087842,1276,82.08563912,0.260957686,-1.938112202,{"v":1.5673E-115,"d":"1.57E-115"},{"v":3.1916e-114,"d":"3.19E-114"},"down","yes","Osmr","protein_coding","chr2:55907132-55961262:-","gi|564335465|ref|XP_006232074.1|",5038,0,"PREDICTED: oncostatin-M-specific receptor subunit beta isoform X1 [Rattus norvegicus]","gi|672041560|ref|XM_006232012.2|",4611,0,"PREDICTED: Rattus norvegicus oncostatin M receptor (Osmr), transcript variant X1, mRNA","Q65Z14",1944,0,"Oncostatin-M-specific receptor subunit beta",".",".",".",".","pfam00041","fn3","Fibronectin type III domain.","GO:0008284|positive regulation of cell proliferation;GO:0019221|cytokine-mediated signaling pathway;GO:0034097|response to cytokine;GO:0038165|oncostatin-M-mediated signaling pathway;GO:0048861|leukemia inhibitory factor signaling pathway;","GO:0005900|oncostatin-M receptor complex;GO:0009897|external side of plasma membrane;GO:0016020|membrane;GO:0016324|apical plasma membrane;GO:0043235|receptor complex;","GO:0004896|cytokine receptor activity;GO:0004923|leukemia inhibitory factor receptor activity;GO:0004924|oncostatin-M receptor activity;GO:0005127|ciliary neurotrophic factor receptor binding;GO:0019838|growth factor binding;GO:0019955|cytokine binding;","K05057","OSMR; oncostatin M receptor"]
["ENSRNOG00000068412",760,63.100262,2354,151.4338515,0.416685314,-1.262969841,{"v":2.1522e-114,"d":"2.15E-114"},{"v":4.3548e-113,"d":"4.35E-113"},"down","yes","Fosl2","protein_coding","chr6:24300956-24320034:-","gi|363548413|sp|P51145.2|FOSL2_RAT",1089,{"v":2e-133,"d":"2.00E-133"},"RecName: Full=Fos-related antigen 2; Short=FRA-2","gi|74219059|dbj|AK145822.1|",937,0,"Mus musculus 15 days pregnant adult female placenta cDNA, RIKEN full-length enriched library, clone:I530001P11 product:fos-like antigen 2, full insert sequence","P51145",424,{"v":8e-135,"d":"8.00E-135"},"Fos-related antigen 2",".",".",".",".","pfam00999","Na_H_Exchanger","Sodium/hydrogen exchanger family. Na/H antiporters are key transporters in maintaining the pH of actively metabolizing cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.",".",".",".",".","."]
["ENSRNOG00000043445",325,26.98366467,1421,91.41355266,0.295182321,-1.760321775,{"v":6.2706e-113,"d":"6.27E-113"},{"v":1.253E-111,"d":"1.25E-111"},"down","yes","Them5","protein_coding","chr2:181980783-181986002:+","gi|157819023|ref|NP_001102028.1|",1261,{"v":2E-171,"d":"2.00E-171"},"acyl-coenzyme A thioesterase THEM5 [Rattus norvegicus]","gi|157819022|ref|NM_001108558.1|",1203,0,"Rattus norvegicus thioesterase superfamily member 5 (Them5), mRNA","Q9CQJ0",457,{"v":4E-160,"d":"4.00E-160"},"Acyl-coenzyme A thioesterase THEM5",".",".",".",".","pfam03061","4HBT","Thioesterase superfamily. This family contains a wide variety of enzymes, principally thioesterases. This family includes 4HBT (EC 3.1.2.23) which catalyses the final step in the biosynthesis of 4-hydroxybenzoate from 4-chlorobenzoate in the soil dwelling microbe Pseudomonas CBS-3. This family includes various cytosolic long-chain acyl-CoA thioester hydrolases. Long-chain acyl-CoA hydrolases hydrolyse palmitoyl-CoA to CoA and palmitate, they also catalyse the hydrolysis of other long chain fatty acyl-CoA thioesters.","GO:0035336|long-chain fatty-acyl-CoA metabolic process;GO:0035965|cardiolipin acyl-chain remodeling;","GO:0005759|mitochondrial matrix;","GO:0016290|palmitoyl-CoA hydrolase activity;","K22554","THEM5; acyl-coenzyme A thioesterase THEM5 [EC:3.1.2.2]"]
["ENSRNOG00000066193",411,34.12395748,1615,103.8936577,0.328450824,-1.60625071,{"v":9.9456e-113,"d":"9.95E-113"},{"v":1.9811e-111,"d":"1.98E-111"},"down","yes","Zfp862","protein_coding","chr4:77453037-77481995:+","gi|672018269|ref|XP_008773951.1|",5440,0,"PREDICTED: zinc finger protein 862 [Rattus norvegicus]","gi|169235008|gb|AC135090.3|",6728,0,"Rattus norvegicus BAC CH230-446D1 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","O60290",1522,0,"Zinc finger protein 862",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000015093",1260,104.6135923,3284,211.261159,0.495186114,-1.013957237,{"v":3.5437e-112,"d":"3.54E-112"},{"v":6.9935e-111,"d":"6.99E-111"},"down","yes","Sparcl1","protein_coding","chr14:5632569-5663865:+","gi|149046729|gb|EDL99503.1|",3014,0,"SPARC-like 1 (mast9, hevin), isoform CRA_a [Rattus norvegicus]","gi|38197695|gb|BC061755.1|",2629,0,"Rattus norvegicus SPARC-like 1 (hevin), mRNA (cDNA clone MGC:72541 IMAGE:5600008), complete cds","P24054",1159,0,"SPARC-like protein 1",".",".",".",".","pfam10591","SPARC_Ca_bdg","Secreted protein acidic and rich in cysteine Ca binding region. The SPARC_Ca_bdg domain of Secreted Protein Acidic and Rich in Cysteine is responsible for the anti-spreading activity of human urothelial cells. It is rich in alpha-helices. This extracellular calcium-binding domain contains two EF-hands that each coordinates one Ca2+ ion, forming a helix-loop-helix structure that not only drives the conformation of the protein but is also necessary for biological activity. The anti-spreading activity was dependent on the coordination of Ca2+ by a Glu residue at the Z position of EF-hand 2.","GO:0007165|signal transduction;GO:0048856|anatomical structure development;GO:0050807|regulation of synapse organization;GO:0099560|synaptic membrane adhesion;","GO:0005615|extracellular space;GO:0045202|synapse;GO:0062023|collagen-containing extracellular matrix;GO:0098965|extracellular matrix of synaptic cleft;GO:0098978|glutamatergic synapse;","GO:0005509|calcium ion binding;GO:0005518|collagen binding;GO:0050840|extracellular matrix binding;",".","."]
["ENSRNOG00000018028",162,13.45031901,1010,64.97374257,0.207011609,-2.272216419,{"v":5.2107e-112,"d":"5.21E-112"},{"v":1.0252E-110,"d":"1.03E-110"},"down","yes","Testin","protein_coding","chr17:3846899-3859385:+","gi|27465595|ref|NP_775155.1|",1819,0,"testin-2 precursor [Rattus norvegicus]","gi|402693052|ref|NM_173132.2|",1358,0,"Rattus norvegicus testin gene (Testin), mRNA","P15242",705,0,"Testin-2","AF1946_2",72,{"v":2e-13,"d":"2.00E-13"},"COG4870","pfam00112","Peptidase_C1","Papain family cysteine protease.","GO:0006955|immune response;GO:0051603|proteolysis involved in cellular protein catabolic process;","GO:0005615|extracellular space;GO:0005764|lysosome;GO:0030054|cell junction;","GO:0004197|cysteine-type endopeptidase activity;","K24271","Testin; testin-2"]
["ENSRNOG00000068605",533,44.25321006,1866,120.0405977,0.36865203,-1.439668392,{"v":6.9162e-111,"d":"6.92E-111"},{"v":1.3483E-109,"d":"1.35E-109"},"down","yes","ENSRNOG00000068605","protein_coding","chr1:7387083-7395497:+","gi|148676020|gb|EDL07967.1|",1100,{"v":9e-135,"d":"9.00E-135"},"mCG1029965 [Mus musculus]","gi|46240867|gb|AC107531.8|",2360,0,"Rattus norvegicus 1 BAC CH230-158N3 (Children's Hospital Oakland Research Institute) complete sequence","P31789",197,{"v":3E-52,"d":"3.00E-52"},"Envelope glycoprotein",".",".",".",".","pfam11822","DUF3342","Domain of unknown function (DUF3342). This family of proteins are functionally uncharacterized. This family is found in bacteria. This presumed domain is typically between 170 to 303 amino acids in length. The N-terminal half of this family is a BTB-like domain.",".",".",".",".","."]
["ENSRNOG00000069240",144,11.95583912,946,60.85659452,0.19645922,-2.347698216,{"v":3.7146e-109,"d":"3.71E-109"},{"v":7.1326e-108,"d":"7.13E-108"},"down","yes","ENSRNOG00000069240","protein_coding","chr11:12193771-12199421:-","gi|852749799|ref|XP_012872059.1|",906,{"v":1E-108,"d":"1.00E-108"},"PREDICTED: endogenous retrovirus group K member 8 Pol protein-like [Dipodomys ordii]","gi|153791782|ref|NG_006339.2|",1903,0,"Rattus norvegicus vomeronasal 2 receptor, pseudogene 55 (Vom2r-ps55) on chromosome 1","P04026",299,{"v":3e-91,"d":"3.00E-91"},"Intracisternal A-particle Pol-related polyprotein (Fragment)",".",".",".",".","pfam00665","rve","Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyses the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.",".",".",".",".","."]
["ENSRNOG00000000800",1071,88.92155342,2893,186.1079577,0.477795547,-1.065534687,{"v":2.7855e-107,"d":"2.79E-107"},{"v":5.2079e-106,"d":"5.21E-106"},"down","yes","Man1a1","protein_coding","chr20:33202517-33385824:-","gi|564398053|ref|XP_006256559.1|",3676,0,"PREDICTED: mannosyl-oligosaccharide 1,2-alpha-mannosidase IA isoform X1 [Rattus norvegicus]","gi|75905482|ref|NM_001033656.1|",3857,0,"Rattus norvegicus mannosidase, alpha, class 1A, member 1 (Man1a1), mRNA","P45700",1238,0,"Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA",".",".",".",".","pfam01532","Glyco_hydro_47","Glycosyl hydrolase family 47. Members of this family are alpha-mannosidases that catalyse the hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2).","GO:0005975|carbohydrate metabolic process;GO:0006491|N-glycan processing;GO:0030433|ubiquitin-dependent ERAD pathway;GO:0045047|protein targeting to ER;GO:1904382|mannose trimming involved in glycoprotein ERAD pathway;","GO:0000139|Golgi membrane;GO:0005783|endoplasmic reticulum;GO:0005793|endoplasmic reticulum-Golgi intermediate compartment;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0016021|integral component of membrane;GO:0031410|cytoplasmic vesicle;","GO:0004571|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity;GO:0005509|calcium ion binding;","K01230","MAN1A_C, MNS1_2; mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113]"]
["ENSRNOG00000061910",200,16.6053321,1082,69.60553412,0.238563389,-2.067555438,{"v":9.4991e-107,"d":"9.50E-107"},{"v":1.7554e-105,"d":"1.76E-105"},"down","yes","Igfbp3","protein_coding","chr14:82056347-82064083:-","gi|124064|sp|P15473.2|IBP3_RAT",1160,{"v":1e-149,"d":"1.00E-149"},"RecName: Full=Insulin-like growth factor-binding protein 3; Short=IBP-3; Short=IGF-binding protein 3; Short=IGFBP-3; Flags: Precursor","gi|298231181|ref|NM_012588.2|",2416,0,"Rattus norvegicus insulin-like growth factor binding protein 3 (Igfbp3), mRNA","P15473",451,{"v":3e-151,"d":"3.00E-151"},"Insulin-like growth factor-binding protein 3",".",".",".",".","pfam00086","Thyroglobulin_1","Thyroglobulin type-1 repeat. Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.","GO:0001558|regulation of cell growth;GO:0001649|osteoblast differentiation;GO:0001666|response to hypoxia;GO:0001933|negative regulation of protein phosphorylation;GO:0006468|protein phosphorylation;GO:0007565|female pregnancy;GO:0007568|aging;GO:0008285|negative regulation of cell proliferation;GO:0009410|response to xenobiotic stimulus;GO:0010666|positive regulation of cardiac muscle cell apoptotic process;GO:0010906|regulation of glucose metabolic process;GO:0014912|negative regulation of smooth muscle cell migration;GO:0032496|response to lipopolysaccharide;GO:0032868|response to insulin;GO:0040008|regulation of growth;GO:0043065|positive regulation of apoptotic process;GO:0043410|positive regulation of MAPK cascade;GO:0043567|regulation of insulin-like growth factor receptor signaling pathway;GO:0043568|positive regulation of insulin-like growth factor receptor signaling pathway;GO:0044342|type B pancreatic cell proliferation;GO:0045663|positive regulation of myoblast differentiation;GO:0048662|negative regulation of smooth muscle cell proliferation;GO:0050790|regulation of catalytic activity;GO:0060416|response to growth hormone;GO:0061771|response to caloric restriction;GO:0071392|cellular response to estradiol stimulus;GO:1902512|positive regulation of apoptotic DNA fragmentation;GO:1904017|cellular response to Thyroglobulin triiodothyronine;GO:1990418|response to insulin-like growth factor stimulus;GO:2000844|negative regulation of testosterone secretion;","GO:0000792|heterochromatin;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0031091|platelet alpha granule;GO:0042567|insulin-like growth factor ternary complex;GO:0042568|insulin-like growth factor binary complex;","GO:0001968|fibronectin binding;GO:0005515|protein binding;GO:0005520|insulin-like growth factor binding;GO:0008160|protein tyrosine phosphatase activator activity;GO:0031994|insulin-like growth factor I binding;GO:0031995|insulin-like growth factor II binding;","K10138","IGFBP3; insulin-like growth factor-binding protein 3"]
["ENSRNOG00000007152",654,54.29943598,2081,133.8716419,0.405608202,-1.301841268,{"v":3.7528e-106,"d":"3.75E-106"},{"v":6.8953e-105,"d":"6.90E-105"},"down","yes","Bhlhe40","protein_coding","chr4:141618476-141624774:+","gi|744579291|ref|XP_010983292.1|",1906,0,"PREDICTED: class E basic helix-loop-helix protein 40 [Camelus dromedarius]","gi|16758031|ref|NM_053328.1|",2314,0,"Rattus norvegicus basic helix-loop-helix family, member e40 (Bhlhe40), mRNA","O35780",729,0,"Class E basic helix-loop-helix protein 40",".",".",".",".","pfam00010","HLH","Helix-loop-helix DNA-binding domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007399|nervous system development;GO:0007623|circadian rhythm;GO:0009416|response to light stimulus;GO:0009952|anterior/posterior pattern specification;GO:0032922|circadian regulation of gene expression;GO:0042752|regulation of circadian rhythm;GO:0043153|entrainment of circadian clock by photoperiod;GO:0043433|negative regulation of DNA-binding transcription factor activity;GO:0045892|negative regulation of transcription, DNA-templated;GO:0048168|regulation of neuronal synaptic plasticity;GO:0050767|regulation of neurogenesis;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0016604|nuclear body;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0019904|protein domain specific binding;GO:0042803|protein homodimerization activity;GO:0043425|bHLH transcription factor binding;GO:0043426|MRF binding;GO:0046982|protein heterodimerization activity;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;GO:0070888|E-box binding;GO:1990837|sequence-specific double-stranded DNA binding;","K03729","BHLHB2, DEC1; class B basic helix-loop-helix protein 2"]
["ENSRNOG00000050869",477,39.60371707,1713,110.1980406,0.359386763,-1.476390824,{"v":8.6245e-106,"d":"8.62E-106"},{"v":1.5756e-104,"d":"1.58E-104"},"down","yes","Cebpd","protein_coding","chr11:84764565-84765829:+","gi|6978643|ref|NP_037286.1|",1282,{"v":5e-174,"d":"5.00E-174"},"CCAAT/enhancer-binding protein delta [Rattus norvegicus]","gi|125656964|ref|NM_013154.2|",1139,0,"Rattus norvegicus CCAAT/enhancer binding protein delta (Cebpd), mRNA","Q03484",498,{"v":2E-175,"d":"2.00E-175"},"CCAAT/enhancer-binding protein delta",".",".",".",".","pfam07716","bZIP_2","Basic region leucine zipper.","GO:0002244|hematopoietic progenitor cell differentiation;GO:0006357|regulation of transcription by RNA polymerase II;GO:0045444|fat cell differentiation;GO:0045595|regulation of cell differentiation;GO:0045669|positive regulation of osteoblast differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048839|inner ear development;","GO:0005634|nucleus;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0042802|identical protein binding;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K10050","CEBPD; CCAAT/enhancer binding protein (C/EBP), delta"]
["ENSRNOG00000065003",234,19.42823856,1161,74.68763873,0.26012656,-1.942714381,{"v":1.2751e-105,"d":"1.28E-105"},{"v":2.3228E-104,"d":"2.32E-104"},"down","yes","Abcg3l4","protein_coding","chr14:4545223-4585347:-","gi|81295367|ref|NP_001032282.1|",3224,0,"ATP-binding cassette, subfamily G (WHITE), member 3-like 4 [Rattus norvegicus]","gi|81295366|ref|NM_001037205.1|",2710,0,"Rattus norvegicus ATP-binding cassette, subfamily G (WHITE), member 3-like 4 (Abcg3l4), mRNA","Q99P81",951,0,"ATP-binding cassette sub-family G member 3","SPCC18B5.01c_2",132,{"v":2e-32,"d":"2.00E-32"},"COG1131","pfam01061","ABC2_membrane","ABC-2 type transporter.",".",".",".",".","."]
["ENSRNOG00000051563",670,55.62786255,2104,135.3512419,0.410988933,-1.282828548,{"v":6.3246E-105,"d":"6.32E-105"},{"v":1.1424E-103,"d":"1.14E-103"},"down","yes","Giot1","protein_coding","chr7:10202982-10237099:-","gi|149034696|gb|EDL89433.1|",3512,0,"rCG29351 [Rattus norvegicus]","gi|19424247|ref|NM_133563.1|",2544,0,"Rattus norvegicus gonadotropin inducible ovarian transcription factor 1 (Giot1), mRNA","Q8N972",582,0,"Zinc finger protein 709",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0000122|negative regulation of transcription by RNA polymerase II;","GO:0005737|cytoplasm;","GO:0046872|metal ion binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSRNOG00000018602",832,69.07818156,2420,155.6796604,0.443720017,-1.172278458,{"v":1.0106e-104,"d":"1.01E-104"},{"v":1.8202e-103,"d":"1.82E-103"},"down","yes","Camta1","protein_coding","chr5:161510283-162356723:-","gi|307133744|ref|NP_001182488.1|",8450,0,"calmodulin-binding transcription activator 1 isoform 1 [Rattus norvegicus]","gi|307133743|ref|NM_001195559.1|",8460,0,"Rattus norvegicus calmodulin binding transcription activator 1 (Camta1), transcript variant 1, mRNA","A2A891",3160,0,"Calmodulin-binding transcription activator 1",".",".",".",".","pfam03859","CG-1","CG-1 domain. CG-1 domains are highly conserved domains of about 130 amino-acid residues containing a predicted bipartite NLS and named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs.","GO:0035307|positive regulation of protein dephosphorylation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050885|neuromuscular process controlling balance;GO:0070886|positive regulation of calcineurin-NFAT signaling cascade;","GO:0005730|nucleolus;GO:0005829|cytosol;","GO:0043565|sequence-specific DNA binding;","K21596","CAMTA; calmodulin-binding transcription activator"]
["ENSRNOG00000028426",437,36.28265065,1599,102.8643707,0.352723206,-1.503391598,{"v":1.6047e-101,"d":"1.60E-101"},{"v":2.7657e-100,"d":"2.77E-100"},"down","yes","Mcf2l","protein_coding","chr16:76507133-76652733:-","gi|564389916|ref|XP_006253483.1|",6041,0,"PREDICTED: guanine nucleotide exchange factor DBS isoform X4 [Rattus norvegicus]","gi|672080666|ref|XM_006253421.2|",8099,0,"PREDICTED: Rattus norvegicus MCF.2 cell line derived transforming sequence-like (Mcf2l), transcript variant X4, mRNA","Q63406",2076,0,"Guanine nucleotide exchange factor DBS",".",".",".",".","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0007266|Rho protein signal transduction;GO:0035025|positive regulation of Rho protein signal transduction;GO:0035556|intracellular signal transduction;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050790|regulation of catalytic activity;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0012505|endomembrane system;GO:0016020|membrane;GO:0019898|extrinsic component of membrane;GO:0030027|lamellipodium;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0005545|1-phosphatidylinositol binding;GO:0035091|phosphatidylinositol binding;","K20685","MCF2, ARHGEF14_21_22; guanine nucleotide exchange factor MCF2"]
["ENSRNOG00000000167",29,2.407773155,547,35.18874969,0.068424516,-3.869342871,{"v":2.532e-101,"d":"2.53E-101"},{"v":4.3288E-100,"d":"4.33E-100"},"down","yes","ENSRNOG00000000167","protein_coding","chrX:19463171-19486519:+","gi|51980582|gb|AAH81857.1|",3064,0,"Aminolevulinate, delta-, synthase 2 [Rattus norvegicus]","gi|156255175|ref|NM_001102446.1|",1674,0,"Mus musculus aminolevulinic acid synthase 2, erythroid (Alas2), transcript variant 2, mRNA","Q63147",1183,0,"5-aminolevulinate synthase, erythroid-specific, mitochondrial","AGc4738",412,{"v":2E-136,"d":"2.00E-136"},"COG0156","pfam00155","Aminotran_1_2","Aminotransferase class I and II.","GO:0001666|response to hypoxia;GO:0006782|protoporphyrinogen IX biosynthetic process;GO:0006783|heme biosynthetic process;GO:0006879|cellular iron ion homeostasis;GO:0007595|lactation;GO:0009410|response to xenobiotic stimulus;GO:0010288|response to lead ion;GO:0030218|erythrocyte differentiation;GO:0032025|response to cobalt ion;GO:0042541|hemoglobin biosynthetic process;GO:0048821|erythrocyte development;GO:0060135|maternal process involved in female pregnancy;GO:0070542|response to fatty acid;GO:0097421|liver regeneration;GO:1901423|response to benzene;","GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0005759|mitochondrial matrix;","GO:0003870|5-aminolevulinate synthase activity;GO:0030170|pyridoxal phosphate binding;","K00643","E2.3.1.37, ALAS; 5-aminolevulinate synthase [EC:2.3.1.37]"]
["ENSRNOG00000017601",344,28.56117122,1356,87.23207418,0.327415936,-1.610803552,{"v":2.42529E-95,"d":"2.43E-95"},{"v":3.94594e-94,"d":"3.95E-94"},"down","yes","Srd5a1","protein_coding","chr1:33686391-33720461:+","gi|2507119|sp|P24008.2|S5A1_RAT",1195,{"v":2e-154,"d":"2.00E-154"},"RecName: Full=3-oxo-5-alpha-steroid 4-dehydrogenase 1; AltName: Full=SR type 1; AltName: Full=Steroid 5-alpha-reductase 1; Short=S5AR 1","gi|117558799|gb|BC127454.1|",2613,0,"Rattus norvegicus steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1), mRNA (cDNA clone MGC:156498 IMAGE:7313862), complete cds","P24008",464,{"v":7e-156,"d":"7.00E-156"},"3-oxo-5-alpha-steroid 4-dehydrogenase 1",".",".",".",".","pfam02544","Steroid_dh","3-oxo-5-alpha-steroid 4-dehydrogenase. This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalysed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor <=> 3-oxo-delta(4)-steroid + reduced acceptor. The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally. A related enzyme is also found in plants is DET2, a steroid reductase from Arabidopsis. Mutations in this enzyme cause defects in light-regulated development.","GO:0001655|urogenital system development;GO:0001889|liver development;GO:0006694|steroid biosynthetic process;GO:0006702|androgen biosynthetic process;GO:0006710|androgen catabolic process;GO:0008209|androgen metabolic process;GO:0008584|male gonad development;GO:0009267|cellular response to starvation;GO:0009410|response to xenobiotic stimulus;GO:0014070|response to organic cyclic compound;GO:0014850|response to muscle activity;GO:0016101|diterpenoid metabolic process;GO:0021510|spinal cord development;GO:0021766|hippocampus development;GO:0021794|thalamus development;GO:0021854|hypothalamus development;GO:0021983|pituitary gland development;GO:0021987|cerebral cortex development;GO:0030154|cell differentiation;GO:0030539|male genitalia development;GO:0030540|female genitalia development;GO:0032354|response to follicle-stimulating hormone;GO:0032355|response to estradiol;GO:0032869|cellular response to insulin stimulus;GO:0033574|response to testosterone;GO:0042428|serotonin metabolic process;GO:0042448|progesterone metabolic process;GO:0042747|circadian sleep/wake cycle, REM sleep;GO:0043627|response to estrogen;GO:0046661|male sex differentiation;GO:0060348|bone development;GO:0060416|response to growth hormone;GO:0060992|response to fungicide;GO:0071320|cellular response to cAMP;GO:0071363|cellular response to growth factor stimulus;GO:0071392|cellular response to estradiol stimulus;GO:0071394|cellular response to testosterone stimulus;GO:0071407|cellular response to organic cyclic compound;GO:0071549|cellular response to dexamethasone stimulus;GO:0071872|cellular response to epinephrine stimulus;","GO:0005737|cytoplasm;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0043025|neuronal cell body;GO:0043209|myelin sheath;GO:0043231|intracellular membrane-bounded organelle;GO:0048471|perinuclear region of cytoplasm;GO:0070852|cell body fiber;","GO:0003865|3-oxo-5-alpha-steroid 4-dehydrogenase activity;GO:0016491|oxidoreductase activity;GO:0033218|amide binding;GO:0047751|cholestenone 5-alpha-reductase activity;GO:0050213|progesterone 5-alpha-reductase activity;GO:0070402|NADPH binding;","K12343","SRD5A1; 3-oxo-5-alpha-steroid 4-dehydrogenase 1 [EC:1.3.1.22]"]
["ENSRNOG00000002011",1005,83.44179383,2655,170.7973134,0.488542777,-1.033443203,{"v":6.77461e-94,"d":"6.77E-94"},{"v":1.08294e-92,"d":"1.08E-92"},"down","yes","Gnrhr","protein_coding","chr14:21856871-21874861:+","gi|407039|gb|AAA41265.1|",1756,0,"gonadotropin-releasing hormone receptor [Rattus norvegicus]","gi|77812701|ref|NM_031038.3|",2611,0,"Rattus norvegicus gonadotropin releasing hormone receptor (Gnrhr), mRNA","P30969",622,0,"Gonadotropin-releasing hormone receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0007623|circadian rhythm;GO:0008285|negative regulation of cell proliferation;GO:0097211|cellular response to gonadotropin-releasing hormone;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004968|gonadotropin-releasing hormone receptor activity;GO:0005515|protein binding;GO:0016500|protein-hormone receptor activity;GO:0016520|growth hormone-releasing hormone receptor activity;GO:0042277|peptide binding;","K04280","GNRHR; gonadotropin-releasing hormone receptor"]
["ENSRNOG00000005660",171,14.19755895,937,60.27762058,0.235536154,-2.085979567,{"v":9.71416e-94,"d":"9.71E-94"},{"v":1.54511e-92,"d":"1.55E-92"},"down","yes","Fam110c","protein_coding","chr6:47638276-47644634:+","gi|68163531|ref|NP_001020222.1|",1318,{"v":1E-169,"d":"1.00E-169"},"protein FAM110C [Rattus norvegicus]","gi|68163530|ref|NM_001025051.1|",3024,0,"Rattus norvegicus family with sequence similarity 110, member C (Fam110c), mRNA","Q5RKJ0",512,{"v":4e-171,"d":"4.00E-171"},"Protein FAM110C",".",".",".",".","pfam14160","FAM110_C","Centrosome-associated C terminus. This is the C-terminus of a family of proteins that colocalize with the centrosome/microtubule organisation centre in interphase and at the spindle poles in mitosis.","GO:0030335|positive regulation of cell migration;GO:0051897|positive regulation of protein kinase B signaling;GO:0060491|regulation of cell projection assembly;","GO:0000922|spindle pole;GO:0005634|nucleus;GO:0005815|microtubule organizing center;GO:0005874|microtubule;GO:0005938|cell cortex;","GO:0043014|alpha-tubulin binding;",".","."]
["ENSRNOG00000029651",143,11.87281246,854,54.93819421,0.216112172,-2.210147767,{"v":6.58916e-92,"d":"6.59E-92"},{"v":1.03518e-90,"d":"1.04E-90"},"down","yes","Rdh16","protein_coding","chr7:63597536-63624124:+","gi|40363270|ref|NP_954678.1|",1686,0,"retinol dehydrogenase 2 precursor [Rattus norvegicus]","gi|40363269|ref|NM_199208.1|",1821,0,"Rattus norvegicus retinol dehydrogenase 16 (all-trans) (Rdh16), mRNA","P50170",654,0,"Retinol dehydrogenase 2",".",".",".",".","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.","GO:0001523|retinoid metabolic process;GO:0008202|steroid metabolic process;GO:0042572|retinol metabolic process;GO:0042573|retinoic acid metabolic process;GO:0042904|9-cis-retinoic acid biosynthetic process;GO:1900054|positive regulation of retinoic acid biosynthetic process;","GO:0005788|endoplasmic reticulum lumen;GO:0005789|endoplasmic reticulum membrane;GO:0031301|integral component of organelle membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0004745|retinol dehydrogenase activity;GO:0042802|identical protein binding;GO:0047023|androsterone dehydrogenase activity;GO:0047044|androstan-3-alpha,17-beta-diol dehydrogenase activity;","K11154","RDH16; retinol dehydrogenase 16 [EC:1.1.1.-]"]
["ENSRNOG00000000903",729,60.52643552,2118,136.2518681,0.444224629,-1.170638713,{"v":1.08095E-91,"d":"1.08E-91"},{"v":1.69405e-90,"d":"1.69E-90"},"down","yes","Asl","protein_coding","chr12:26659565-26679662:+","gi|31377525|ref|NP_067588.2|",2465,0,"argininosuccinate lyase [Rattus norvegicus]","gi|148747348|ref|NM_021577.3|",2073,0,"Rattus norvegicus argininosuccinate lyase (Asl), mRNA","P20673",947,0,"Argininosuccinate lyase","SPBC1539.03c",566,0,"COG0165","pfam00206","Lyase_1","Lyase.","GO:0000050|urea cycle;GO:0000053|argininosuccinate metabolic process;GO:0001822|kidney development;GO:0001889|liver development;GO:0006520|cellular amino acid metabolic process;GO:0006526|arginine biosynthetic process;GO:0007494|midgut development;GO:0007568|aging;GO:0007584|response to nutrient;GO:0007626|locomotory behavior;GO:0009410|response to xenobiotic stimulus;GO:0009636|response to toxic substance;GO:0009791|post-embryonic development;GO:0010043|response to zinc ion;GO:0014075|response to amine;GO:0019676|ammonia assimilation cycle;GO:0032496|response to lipopolysaccharide;GO:0042450|arginine biosynthetic process via ornithine;GO:0043434|response to peptide hormone;GO:0048545|response to steroid hormone;GO:0060416|response to growth hormone;GO:0060539|diaphragm development;GO:0071242|cellular response to ammonium ion;GO:0071320|cellular response to cAMP;GO:0071346|cellular response to interferon-gamma;GO:0071356|cellular response to tumor necrosis factor;GO:0071377|cellular response to glucagon stimulus;GO:0071385|cellular response to glucocorticoid stimulus;GO:0071456|cellular response to hypoxia;GO:0071549|cellular response to dexamethasone stimulus;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005741|mitochondrial outer membrane;GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0048471|perinuclear region of cytoplasm;GO:0070852|cell body fiber;","GO:0004056|argininosuccinate lyase activity;GO:0042802|identical protein binding;","K01755","argH, ASL; argininosuccinate lyase [EC:4.3.2.1]"]
["ENSRNOG00000020254",946,78.54322086,2525,162.4343564,0.483538228,-1.048298143,{"v":1.83828E-91,"d":"1.84E-91"},{"v":2.85989e-90,"d":"2.86E-90"},"down","yes","Per2","protein_coding","chr9:92007296-92049459:-","gi|13928942|ref|NP_113866.1|",5815,0,"period circadian protein homolog 2 [Rattus norvegicus]","gi|13928941|ref|NM_031678.1|",5751,0,"Rattus norvegicus period circadian clock 2 (Per2), mRNA","Q9Z301",2244,0,"Period circadian protein homolog 2",".",".",".",".","pfam12114","Period_C","Period protein 2/3C-terminal region. This domain is found in eukaryotes. This domain is typically between 164 to 200 amino acids in length. This domain is found associated with pfam08447.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0002931|response to ischemia;GO:0005978|glycogen biosynthetic process;GO:0006094|gluconeogenesis;GO:0006631|fatty acid metabolic process;GO:0007623|circadian rhythm;GO:0019229|regulation of vasoconstriction;GO:0019249|lactate biosynthetic process;GO:0031397|negative regulation of protein ubiquitination;GO:0032922|circadian regulation of gene expression;GO:0042752|regulation of circadian rhythm;GO:0042754|negative regulation of circadian rhythm;GO:0043153|entrainment of circadian clock by photoperiod;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0050767|regulation of neurogenesis;GO:0050796|regulation of insulin secretion;GO:0050872|white fat cell differentiation;GO:0051726|regulation of cell cycle;GO:0051946|regulation of glutamate uptake involved in transmission of nerve impulse;GO:0060567|negative regulation of DNA-templated transcription, termination;GO:0070345|negative regulation of fat cell proliferation;GO:0070932|histone H3 deacetylation;GO:0097167|circadian regulation of translation;GO:0120162|positive regulation of cold-induced thermogenesis;GO:2000678|negative regulation of transcription regulatory region DNA binding;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0048471|perinuclear region of cytoplasm;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001222|transcription corepressor binding;GO:0003713|transcription coactivator activity;GO:0005515|protein binding;GO:0016922|nuclear receptor binding;GO:0019900|kinase binding;GO:0036002|pre-mRNA binding;GO:0042802|identical protein binding;GO:0042826|histone deacetylase binding;GO:0070063|RNA polymerase binding;GO:1990226|histone methyltransferase binding;","K02633","PER2; period circadian protein 2"]
["ENSRNOG00000011135",643,53.38614272,1944,125.0583718,0.426889795,-1.22806442,{"v":8.20969e-91,"d":"8.21E-91"},{"v":1.27412E-89,"d":"1.27E-89"},"down","yes","Gtf2b","protein_coding","chr2:231767238-231785651:+","gi|635106759|ref|XP_007976241.1|",1378,{"v":2E-179,"d":"2.00E-179"},"PREDICTED: transcription initiation factor IIB [Chlorocebus sabaeus]","gi|298898349|emb|FQ231337.1|",851,0,"Rattus norvegicus TL0AEA6YN24 mRNA sequence","P62916",530,{"v":5e-180,"d":"5.00E-180"},"Transcription initiation factor IIB","SPAC16E8.16",206,{"v":5e-58,"d":"5.00E-58"},"COG1405","pfam00382","TFIIB","Transcription factor TFIIB repeat.","GO:0001174|transcriptional start site selection at RNA polymerase II promoter;GO:0006352|DNA-templated transcription, initiation;GO:0006366|transcription by RNA polymerase II;GO:0006367|transcription initiation from RNA polymerase II promoter;GO:0006473|protein acetylation;GO:0016573|histone acetylation;GO:0019083|viral transcription;GO:0051123|RNA polymerase II preinitiation complex assembly;GO:0070897|transcription preinitiation complex assembly;GO:1904798|positive regulation of core promoter binding;GO:1990114|RNA polymerase II core complex assembly;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005669|transcription factor TFIID complex;GO:0005694|chromosome;GO:0016604|nuclear body;GO:0032993|protein-DNA complex;GO:0090575|RNA polymerase II transcription factor complex;GO:0097550|transcriptional preinitiation complex;","GO:0000979|RNA polymerase II core promoter sequence-specific DNA binding;GO:0000993|RNA polymerase II complex binding;GO:0003677|DNA binding;GO:0004402|histone acetyltransferase activity;GO:0008270|zinc ion binding;GO:0016251|RNA polymerase II general transcription initiation factor activity;GO:0016407|acetyltransferase activity;GO:0017025|TBP-class protein binding;GO:0046966|thyroid hormone receptor binding;GO:1990841|promoter-specific chromatin binding;","K03124","TFIIB, GTF2B, SUA7, tfb; transcription initiation factor TFIIB"]
["ENSRNOG00000002093",170,14.11453229,915,58.86235094,0.239788796,-2.060163841,{"v":3.65554E-90,"d":"3.66E-90"},{"v":5.65188e-89,"d":"5.65E-89"},"down","yes","Tgfbr3","protein_coding","chr14:2489397-2663341:+","gi|8394446|ref|NP_058952.1|",4411,0,"transforming growth factor beta receptor type 3 precursor [Rattus norvegicus]","gi|8394445|ref|NM_017256.1|",3913,0,"Rattus norvegicus transforming growth factor, beta receptor III (Tgfbr3), mRNA","P26342",1703,0,"Transforming growth factor beta receptor type 3",".",".",".",".","pfam00100","Zona_pellucida","Zona pellucida-like domain.","GO:0001568|blood vessel development;GO:0001570|vasculogenesis;GO:0001649|osteoblast differentiation;GO:0001666|response to hypoxia;GO:0001701|in utero embryonic development;GO:0001824|blastocyst development;GO:0001837|epithelial to mesenchymal transition;GO:0001889|liver development;GO:0001974|blood vessel remodeling;GO:0003150|muscular septum morphogenesis;GO:0003151|outflow tract morphogenesis;GO:0003223|ventricular compact myocardium morphogenesis;GO:0006955|immune response;GO:0007165|signal transduction;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0007181|transforming growth factor beta receptor complex assembly;GO:0008284|positive regulation of cell proliferation;GO:0010629|negative regulation of gene expression;GO:0010633|negative regulation of epithelial cell migration;GO:0010719|negative regulation of epithelial to mesenchymal transition;GO:0016477|cell migration;GO:0017015|regulation of transforming growth factor beta receptor signaling pathway;GO:0030509|BMP signaling pathway;GO:0030511|positive regulation of transforming growth factor beta receptor signaling pathway;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030513|positive regulation of BMP signaling pathway;GO:0031100|animal organ regeneration;GO:0032354|response to follicle-stimulating hormone;GO:0032963|collagen metabolic process;GO:0034695|response to prostaglandin E;GO:0034699|response to luteinizing hormone;GO:0035556|intracellular signal transduction;GO:0043393|regulation of protein binding;GO:0050680|negative regulation of epithelial cell proliferation;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051271|negative regulation of cellular component movement;GO:0055010|ventricular cardiac muscle tissue morphogenesis;GO:0060021|roof of mouth development;GO:0060038|cardiac muscle cell proliferation;GO:0060045|positive regulation of cardiac muscle cell proliferation;GO:0060216|definitive hemopoiesis;GO:0060317|cardiac epithelial to mesenchymal transition;GO:0060318|definitive erythrocyte differentiation;GO:0060347|heart trabecula formation;GO:0060389|pathway-restricted SMAD protein phosphorylation;GO:0060412|ventricular septum morphogenesis;GO:0060939|epicardium-derived cardiac fibroblast cell development;GO:0060979|vasculogenesis involved in coronary vascular morphogenesis;GO:0061384|heart trabecula morphogenesis;GO:0062009|secondary palate development;GO:0065003|protein-containing complex assembly;GO:1902338|negative regulation of apoptotic process involved in morphogenesis;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0031012|extracellular matrix;GO:0034673|inhibin-betaglycan-ActRII complex;GO:0043235|receptor complex;GO:0062023|collagen-containing extracellular matrix;","GO:0005024|transforming growth factor beta-activated receptor activity;GO:0005114|type II transforming growth factor beta receptor binding;GO:0005160|transforming growth factor beta receptor binding;GO:0005515|protein binding;GO:0005539|glycosaminoglycan binding;GO:0008201|heparin binding;GO:0015026|coreceptor activity;GO:0017134|fibroblast growth factor binding;GO:0030165|PDZ domain binding;GO:0046332|SMAD binding;GO:0048185|activin binding;GO:0050431|transforming growth factor beta binding;GO:0070123|transforming growth factor beta receptor activity, type III;","K05843","TGFBR3; transforming growth factor, beta receptor III"]
["ENSRNOG00000020196",422,35.03725074,1463,94.11543106,0.372279554,-1.425541709,{"v":4.26299e-86,"d":"4.26E-86"},{"v":6.30972e-85,"d":"6.31E-85"},"down","yes","Scgb1a1","protein_coding","chr1:205977060-205980610:-","gi|6981694|ref|NP_037183.1|",420,{"v":3e-50,"d":"3.00E-50"},"uteroglobin precursor [Rattus norvegicus]","gi|6981693|ref|NM_013051.1|",454,0,"Rattus norvegicus secretoglobin family 1A member 1 (Scgb1a1), mRNA","P17559",166,{"v":1E-51,"d":"1.00E-51"},"Uteroglobin",".",".",".",".","pfam01099","Uteroglobin","Uteroglobin family. Uteroglobin is a homodimer of two identical 70 amino acid polypeptides linked by two disulphide bridges. The precise role of uteroglobin has still to be elucidated.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0007165|signal transduction;GO:0009410|response to xenobiotic stimulus;GO:0010033|response to organic substance;GO:0010193|response to ozone;GO:0032496|response to lipopolysaccharide;GO:0032689|negative regulation of interferon-gamma production;GO:0032696|negative regulation of interleukin-13 production;GO:0032713|negative regulation of interleukin-4 production;GO:0032714|negative regulation of interleukin-5 production;GO:0034021|response to silicon dioxide;GO:0034097|response to cytokine;GO:0042130|negative regulation of T cell proliferation;GO:0043086|negative regulation of catalytic activity;GO:0043488|regulation of mRNA stability;GO:0050727|regulation of inflammatory response;GO:0051384|response to glucocorticoid;GO:0071774|response to fibroblast growth factor;","GO:0005615|extracellular space;GO:0005635|nuclear envelope;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005791|rough endoplasmic reticulum;GO:0030141|secretory granule;","GO:0019834|phospholipase A2 inhibitor activity;GO:0097160|polychlorinated biphenyl binding;","K25464","SCGB1A, CC10; secretoglobin family 1A (uteroglobin)"]
["ENSRNOG00000003616",399,33.12763755,1411,90.77024828,0.364961407,-1.45418418,{"v":1.44967e-85,"d":"1.45E-85"},{"v":2.13088e-84,"d":"2.13E-84"},"down","yes","Grem2","protein_coding","chr13:86778500-86871615:-","gi|157787016|ref|NP_001099444.1|",802,{"v":9e-96,"d":"9.00E-96"},"gremlin-2 precursor [Rattus norvegicus]","gi|157787015|ref|NM_001105974.1|",3716,0,"Rattus norvegicus gremlin 2 (Grem2), mRNA","O88273",312,{"v":9e-97,"d":"9.00E-97"},"Gremlin-2",".",".",".",".","pfam03045","DAN","DAN domain. This domain contains 9 conserved cysteines and is extracellular. Therefore the cysteines may form disulphide bridges. This family of proteins has been termed the DAN family after the first member to be reported. This family includes DAN, Cerberus and Gremlin. The gremlin protein is an antagonist of bone morphogenetic protein signaling. It is postulated that all members of this family antagonise different TGF beta pfam00019 ligands. Recent work shows that the DAN protein is not an efficient antagonist of BMP-2/4 class signals, we found that DAN was able to interact with GDF-5 in a frog embryo assay, suggesting that DAN may regulate signaling by the GDF-5/6/7 class of BMPs in vivo.","GO:0009887|animal organ morphogenesis;GO:0010172|embryonic body morphogenesis;GO:0019221|cytokine-mediated signaling pathway;GO:0030514|negative regulation of BMP signaling pathway;GO:0038098|sequestering of BMP from receptor via BMP binding;GO:0048263|determination of dorsal identity;GO:0060300|regulation of cytokine activity;","GO:0005615|extracellular space;","GO:0005125|cytokine activity;GO:0008201|heparin binding;GO:0036122|BMP binding;GO:0042802|identical protein binding;GO:0048018|receptor ligand activity;","K23318","GREM; gremlin"]
["ENSRNOG00000006076",132,10.95951919,787,50.62805485,0.216471267,-2.20775255,{"v":9.78925e-85,"d":"9.79E-85"},{"v":1.43234E-83,"d":"1.43E-83"},"down","yes","Steap2","protein_coding","chr4:28348362-28375791:+","gi|537250304|gb|ERE88353.1|",2501,0,"metalloreductase STEAP2 [Cricetulus griseus]","gi|157822622|ref|NM_001107846.1|",3376,0,"Rattus norvegicus STEAP2 metalloreductase (Steap2), mRNA","Q8BWB6",952,0,"Metalloreductase STEAP2","RSp1147",70.1,{"v":3e-12,"d":"3.00E-12"},"COG2085","pfam03807","F420_oxidored","NADP oxidoreductase coenzyme F420-dependent.","GO:0006893|Golgi to plasma membrane transport;GO:0006897|endocytosis;GO:0009725|response to hormone;GO:0015677|copper ion import;GO:0045055|regulated exocytosis;GO:0098705|copper ion import across plasma membrane;GO:0098711|iron ion import across plasma membrane;","GO:0005768|endosome;GO:0005769|early endosome;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0010008|endosome membrane;GO:0030140|trans-Golgi network transport vesicle;GO:0030173|integral component of Golgi membrane;","GO:0008823|cupric reductase activity;GO:0052851|ferric-chelate reductase (NADPH) activity;","K14738","STEAP2; metalloreductase STEAP2 [EC:1.16.1.-]"]
["ENSRNOG00000063577",655,54.38246264,1920,123.5144413,0.440292342,-1.183466343,{"v":1.00801E-84,"d":"1.01E-84"},{"v":1.47153E-83,"d":"1.47E-83"},"down","yes","ENSRNOG00000063577","protein_coding","chr1:61368076-61395282:+","gi|672034684|ref|XP_008757045.1|",3362,0,"PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 678-like isoform X2 [Rattus norvegicus]","gi|672034683|ref|XM_008758823.1|",2088,0,"PREDICTED: Rattus norvegicus zinc finger protein 420-like (LOC102550851), transcript variant X2, mRNA","Q8TAQ5",548,0,"Zinc finger protein 420",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000005176",474,39.35463709,1559,100.2911531,0.392403875,-1.349588808,{"v":1.84293e-84,"d":"1.84E-84"},{"v":2.66603e-83,"d":"2.67E-83"},"down","yes","ENSRNOG00000005176","protein_coding","chrX:35372700-35488091:-","gi|576796148|ref|NP_001276707.1|",1599,0,"MAP7 domain-containing protein 2 [Rattus norvegicus]","gi|298913449|emb|FQ214474.1|",2333,0,"Rattus norvegicus TL0AAA41YI02 mRNA sequence","A2AG50",526,{"v":6e-168,"d":"6.00E-168"},"MAP7 domain-containing protein 2",".",".",".",".","pfam05672","MAP7","MAP7 (E-MAP-115) family. The organisation of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilizing protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.","GO:0000226|microtubule cytoskeleton organization;","GO:0015630|microtubule cytoskeleton;",".","K24203","MAP7D2; MAP7 domain-containing protein 2"]
["ENSRNOG00000033663",496,41.18122362,1589,102.2210663,0.402864352,-1.311633943,{"v":1.9536E-82,"d":"1.95E-82"},{"v":2.78208e-81,"d":"2.78E-81"},"down","yes","P4ha2","protein_coding","chr10:38243139-38287314:+","gi|148701600|gb|EDL33547.1|",2957,0,"procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide, isoform CRA_e, partial [Mus musculus]","gi|672067340|ref|XM_008767691.1|",2195,0,"PREDICTED: Rattus norvegicus prolyl 4-hydroxylase, alpha polypeptide II (P4ha2), transcript variant X2, mRNA","Q60716",1031,0,"Prolyl 4-hydroxylase subunit alpha-2",".",".",".",".","pfam08336","P4Ha_N","Prolyl 4-Hydroxylase alpha-subunit, N-terminal region. The members of this family are eukaryotic proteins, and include all three isoforms of the prolyl 4-hydroxylase alpha subunit. This enzyme (EC:1.14.11.2) is important in the post-translational modification of collagen, as it catalyses the formation of 4-hydroxyproline. In vertebrates, the complete enzyme is an alpha2-beta2 tetramer; the beta-subunit is identical to protein disulphide isomerase. The function of the N-terminal region featured in this family does not seem to be known.","GO:0018401|peptidyl-proline hydroxylation to 4-hydroxy-L-proline;","GO:0005581|collagen trimer;GO:0005654|nucleoplasm;GO:0005783|endoplasmic reticulum;GO:0005788|endoplasmic reticulum lumen;GO:0005829|cytosol;GO:0016222|procollagen-proline 4-dioxygenase complex;GO:0043231|intracellular membrane-bounded organelle;","GO:0004656|procollagen-proline 4-dioxygenase activity;GO:0005506|iron ion binding;GO:0031418|L-ascorbic acid binding;","K00472","P4HA; prolyl 4-hydroxylase [EC:1.14.11.2]"]
["ENSRNOG00000009358",644,53.46916938,1878,120.8125629,0.442579547,-1.175991313,{"v":4.2472e-82,"d":"4.25E-82"},{"v":6.02151e-81,"d":"6.02E-81"},"down","yes","Osgin2","protein_coding","chr5:29500408-29520831:-","gi|293347270|ref|XP_001056612.2|",2872,0,"PREDICTED: oxidative stress-induced growth inhibitor 2 isoform X1 [Rattus norvegicus]","gi|672019168|ref|XM_001056612.5|",2363,0,"PREDICTED: Rattus norvegicus oxidative stress induced growth inhibitor family member 2 (Osgin2), transcript variant X1, mRNA","Q9Y236",949,0,"Oxidative stress-induced growth inhibitor 2",".",".",".",".","pfam13738","Pyr_redox_3","Pyridine nucleotide-disulphide oxidoreductase.","GO:0007165|signal transduction;GO:0030308|negative regulation of cell growth;",".","GO:0008083|growth factor activity;",".","."]
["ENSRNOG00000019949",652,54.13338266,1893,121.7775195,0.444526895,-1.169657385,{"v":4.78845e-82,"d":"4.79E-82"},{"v":6.74401e-81,"d":"6.74E-81"},"down","yes","Mrps12","protein_coding","chr1:84025899-84028780:-","gi|157819713|ref|NP_001099709.1|",722,{"v":2e-93,"d":"2.00E-93"},"28S ribosomal protein S12, mitochondrial [Rattus norvegicus]","gi|564327094|ref|XM_006228651.1|",793,0,"PREDICTED: Rattus norvegicus mitochondrial ribosomal protein S12 (Mrps12), transcript variant X2, mRNA","O35680",273,{"v":5E-91,"d":"5.00E-91"},"28S ribosomal protein S12, mitochondrial","FN1558",117,{"v":3e-31,"d":"3.00E-31"},"COG0048","pfam00164","Ribosom_S12_S23","Ribosomal protein S12/S23. This protein is known as S12 in bacteria and archaea and S23 in eukaryotes.","GO:0006412|translation;","GO:0005763|mitochondrial small ribosomal subunit;GO:0005840|ribosome;","GO:0003735|structural constituent of ribosome;","K02950","RP-S12, MRPS12, rpsL; small subunit ribosomal protein S12"]
["ENSRNOG00000024426",199,16.52230544,930,59.82730751,0.276166622,-1.856389129,{"v":4.51538e-80,"d":"4.52E-80"},{"v":6.20899e-79,"d":"6.21E-79"},"down","yes","AABR07032520.1","protein_coding","chr18:67450595-67467044:+","gi|564320831|ref|XP_006222676.1|",1531,0,"PREDICTED: protein maestro isoform X1 [Rattus norvegicus]","gi|672030818|ref|XM_006222615.2|",1403,0,"PREDICTED: Rattus norvegicus maestro (Mro), transcript variant X2, mRNA","Q7TNB4",437,{"v":6e-151,"d":"6.00E-151"},"Protein maestro",".",".",".",".","pfam03999","MAP65_ASE1","Microtubule associated protein (MAP65/ASE1 family).",".",".",".",".","."]
["ENSRNOG00000042560",837,69.49331486,2220,142.8135728,0.486601613,-1.039186993,{"v":1.59156e-79,"d":"1.59E-79"},{"v":2.16985e-78,"d":"2.17E-78"},"down","yes","Bag4","protein_coding","chr16:66288678-66308663:+","gi|68341993|ref|NP_001020301.1|",1287,{"v":1e-158,"d":"1.00E-158"},"BAG family molecular chaperone regulator 4 [Rattus norvegicus]","gi|116686110|ref|NM_026121.3|",2550,0,"Mus musculus BCL2-associated athanogene 4 (Bag4), mRNA","Q8CI61",442,{"v":8e-139,"d":"8.00E-139"},"BAG family molecular chaperone regulator 4",".",".",".",".","pfam02179","BAG","BAG domain. Domain present in Hsp70 regulators.",".",".",".",".","."]
["ENSRNOG00000067321",82,6.808186163,619,39.82054124,0.170971713,-2.548170438,{"v":4.92629e-79,"d":"4.93E-79"},{"v":6.65945E-78,"d":"6.66E-78"},"down","yes","ENSRNOG00000067321","protein_coding","chr16:35360433-35367378:-","gi|33086528|gb|AAP92576.1|",443,{"v":1e-49,"d":"1.00E-49"},"Ab2-051 [Rattus norvegicus]","gi|49615118|gb|AC114512.5|",636,0,"Rattus norvegicus 5 BAC CH230-5N9 (Children's Hospital Oakland Research Institute) complete sequence","P11369",189,{"v":3e-47,"d":"3.00E-47"},"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam10507","DUF2453","Protein of unknown function (DUF2453). Some members of this family are purported to contain GAF domains but this could not be confirmed. The function is not known. It is likely to be a transmembrane protein.",".",".",".",".","."]
["ENSRNOG00000066314",522,43.33991679,1613,103.7649968,0.417673764,-1.25955157,{"v":1.16193e-78,"d":"1.16E-78"},{"v":1.56741e-77,"d":"1.57E-77"},"down","yes","Bean1","protein_coding","chr19:739551-787537:-","gi|564321041|ref|XP_006222720.1|",844,{"v":4e-99,"d":"4.00E-99"},"PREDICTED: protein BEAN1 [Rattus norvegicus]","gi|672031012|ref|XM_008774191.1|",2480,0,"PREDICTED: Rattus norvegicus brain expressed, associated with NEDD4, 1 (Bean1), transcript variant X2, mRNA","Q9EQG5",286,{"v":1e-85,"d":"1.00E-85"},"Protein BEAN1",".",".",".",".","pfam12723","DUF3809","Protein of unknown function (DUF3809). This family of proteins is functionally uncharacterized. This family of proteins is found in Deinococci bacteria. Proteins in this family are typically between 117 and 157 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000015911",889,73.81070121,2302,148.0886687,0.498422343,-1.004559353,{"v":5.02723e-78,"d":"5.03E-78"},{"v":6.72481e-77,"d":"6.72E-77"},"down","yes","Lrp5","protein_coding","chr1:200814250-200917581:-","gi|564332118|ref|XP_006230788.1|",7681,0,"PREDICTED: low-density lipoprotein receptor-related protein 5 isoform X1 [Rattus norvegicus]","gi|672039242|ref|XM_006230726.2|",5125,0,"PREDICTED: Rattus norvegicus low density lipoprotein receptor-related protein 5 (Lrp5), transcript variant X1, mRNA","Q91VN0",2936,0,"Low-density lipoprotein receptor-related protein 5","MT0958_2",55.1,5e-07,"COG3391","pfam00057","Ldl_recept_a","Low-density lipoprotein receptor domain class A.","GO:0001702|gastrulation with mouth forming second;GO:0001944|vasculature development;GO:0002053|positive regulation of mesenchymal cell proliferation;GO:0002076|osteoblast development;GO:0006007|glucose catabolic process;GO:0006897|endocytosis;GO:0008203|cholesterol metabolic process;GO:0008217|regulation of blood pressure;GO:0008284|positive regulation of cell proliferation;GO:0009314|response to radiation;GO:0009952|anterior/posterior pattern specification;GO:0033690|positive regulation of osteoblast proliferation;GO:0035019|somatic stem cell population maintenance;GO:0035108|limb morphogenesis;GO:0035426|extracellular matrix-cell signaling;GO:0042074|cell migration involved in gastrulation;GO:0042632|cholesterol homeostasis;GO:0042733|embryonic digit morphogenesis;GO:0042981|regulation of apoptotic process;GO:0043434|response to peptide hormone;GO:0045600|positive regulation of fat cell differentiation;GO:0045668|negative regulation of osteoblast differentiation;GO:0045669|positive regulation of osteoblast differentiation;GO:0045840|positive regulation of mitotic nuclear division;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046849|bone remodeling;GO:0048539|bone marrow development;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0060033|anatomical structure regression;GO:0060042|retina morphogenesis in camera-type eye;GO:0060070|canonical Wnt signaling pathway;GO:0060348|bone development;GO:0060349|bone morphogenesis;GO:0060444|branching involved in mammary gland duct morphogenesis;GO:0060603|mammary gland duct morphogenesis;GO:0060612|adipose tissue development;GO:0060764|cell-cell signaling involved in mammary gland development;GO:0061178|regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0061299|retina vasculature morphogenesis in camera-type eye;GO:0061304|retinal blood vessel morphogenesis;GO:0071901|negative regulation of protein serine/threonine kinase activity;GO:1902262|apoptotic process involved in blood vessel morphogenesis;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0043235|receptor complex;","GO:0003674|molecular_function;GO:0015026|coreceptor activity;GO:0017147|Wnt-protein binding;GO:0042813|Wnt-activated receptor activity;GO:0071936|coreceptor activity involved in Wnt signaling pathway;","K03068","LRP5_6; low density lipoprotein receptor-related protein 5/6"]
["ENSRNOG00000010780",769,63.84750194,2079,133.742981,0.477389553,-1.066761099,{"v":8.96508e-78,"d":"8.97E-78"},{"v":1.19176E-76,"d":"1.19E-76"},"down","yes","Dlc1","protein_coding","chr16:55291584-55671439:+","gi|302699221|ref|NP_001181869.1|",6949,0,"rho GTPase-activating protein 7 isoform 1 [Mus musculus]","gi|374349250|ref|NM_001194940.2|",4511,0,"Mus musculus deleted in liver cancer 1 (Dlc1), transcript variant 1, mRNA","Q96QB1",2364,0,"Rho GTPase-activating protein 7",".",".",".",".","pfam01852","START","START domain.","GO:0001843|neural tube closure;GO:0003007|heart morphogenesis;GO:0006915|apoptotic process;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007010|cytoskeleton organization;GO:0007165|signal transduction;GO:0007202|activation of phospholipase C activity;GO:0008285|negative regulation of cell proliferation;GO:0008360|regulation of cell shape;GO:0021575|hindbrain morphogenesis;GO:0030036|actin cytoskeleton organization;GO:0030336|negative regulation of cell migration;GO:0030900|forebrain development;GO:0032869|cellular response to insulin stimulus;GO:0032956|regulation of actin cytoskeleton organization;GO:0035023|regulation of Rho protein signal transduction;GO:0035024|negative regulation of Rho protein signal transduction;GO:0035307|positive regulation of protein dephosphorylation;GO:0048041|focal adhesion assembly;GO:0050790|regulation of catalytic activity;GO:0051497|negative regulation of stress fiber assembly;GO:0051895|negative regulation of focal adhesion assembly;GO:1900119|positive regulation of execution phase of apoptosis;","GO:0001725|stress fiber;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005884|actin filament;GO:0005901|caveola;GO:0005925|focal adhesion;GO:0016020|membrane;GO:0030864|cortical actin cytoskeleton;GO:0032587|ruffle membrane;GO:0045121|membrane raft;","GO:0005096|GTPase activator activity;GO:0008289|lipid binding;GO:0017166|vinculin binding;GO:0042169|SH2 domain binding;GO:0043274|phospholipase binding;","K20632","DLC; deleted in liver cancer protein"]
["ENSRNOG00000053691",693,57.53747574,1930,124.1577457,0.463422362,-1.109600434,{"v":5.53951e-77,"d":"5.54E-77"},{"v":7.28811e-76,"d":"7.29E-76"},"down","yes","Lama5","protein_coding","chr3:167270296-167318451:-","gi|300798041|ref|NP_001178538.1|",18755,0,"laminin subunit alpha-5 precursor [Rattus norvegicus]","gi|300798040|ref|NM_001191609.1|",11307,0,"Rattus norvegicus laminin subunit alpha 5 (Lama5), mRNA","Q61001",6720,0,"Laminin subunit alpha-5",".",".",".",".","pfam00055","Laminin_N","Laminin N-terminal (Domain VI).","GO:0001658|branching involved in ureteric bud morphogenesis;GO:0001738|morphogenesis of a polarized epithelium;GO:0001755|neural crest cell migration;GO:0001822|kidney development;GO:0001942|hair follicle development;GO:0007229|integrin-mediated signaling pathway;GO:0007411|axon guidance;GO:0007517|muscle organ development;GO:0009887|animal organ morphogenesis;GO:0009888|tissue development;GO:0016331|morphogenesis of embryonic epithelium;GO:0016477|cell migration;GO:0030155|regulation of cell adhesion;GO:0030324|lung development;GO:0030334|regulation of cell migration;GO:0034446|substrate adhesion-dependent cell spreading;GO:0042127|regulation of cell proliferation;GO:0042475|odontogenesis of dentin-containing tooth;GO:0045995|regulation of embryonic development;GO:0048754|branching morphogenesis of an epithelial tube;GO:0060271|cilium assembly;GO:0060445|branching involved in salivary gland morphogenesis;GO:0072659|protein localization to plasma membrane;GO:0098609|cell-cell adhesion;","GO:0005604|basement membrane;GO:0005610|laminin-5 complex;GO:0005615|extracellular space;GO:0016020|membrane;GO:0031012|extracellular matrix;GO:0031594|neuromuscular junction;GO:0043083|synaptic cleft;GO:0043259|laminin-10 complex;","GO:0005178|integrin binding;GO:0005201|extracellular matrix structural constituent;","K06240","LAMA3_5; laminin, alpha 3/5"]
["ENSRNOG00000063011",493,40.93214364,1536,98.81155305,0.414244513,-1.271445508,{"v":4.46538E-76,"d":"4.47E-76"},{"v":5.75648e-75,"d":"5.76E-75"},"down","yes","ENSRNOG00000063011","protein_coding","chr1:158035673-158044726:+","gi|148676020|gb|EDL07967.1|",1110,{"v":3E-134,"d":"3.00E-134"},"mCG1029965 [Mus musculus]","gi|46240867|gb|AC107531.8|",3250,0,"Rattus norvegicus 1 BAC CH230-158N3 (Children's Hospital Oakland Research Institute) complete sequence","P11369",214,{"v":3e-55,"d":"3.00E-55"},"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam12488","DUF3704","Protein of unknown function (DUF3704). This domain family is found in eukaryotes, and is approximately 30 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000026171",810,67.25159503,2134,137.2811551,0.489882205,-1.029493207,{"v":2.23563e-75,"d":"2.24E-75"},{"v":2.85897E-74,"d":"2.86E-74"},"down","yes","Bbs4","protein_coding","chr8:59731912-59765607:-","gi|672061891|ref|XP_008764446.1|",2439,0,"PREDICTED: Bardet-Biedl syndrome 4 protein isoform X1 [Rattus norvegicus]","gi|672061890|ref|XM_008766224.1|",2639,0,"PREDICTED: Rattus norvegicus Bardet-Biedl syndrome 4 (Bbs4), transcript variant X1, mRNA","Q8C1Z7",884,0,"Bardet-Biedl syndrome 4 protein homolog","MA1362",89.4,{"v":7e-18,"d":"7.00E-18"},"COG0457","pfam13414","TPR_11","TPR repeat.","GO:0000226|microtubule cytoskeleton organization;GO:0000281|mitotic cytokinesis;GO:0001764|neuron migration;GO:0001843|neural tube closure;GO:0001895|retina homeostasis;GO:0003085|negative regulation of systemic arterial blood pressure;GO:0007098|centrosome cycle;GO:0007286|spermatid development;GO:0007608|sensory perception of smell;GO:0008104|protein localization;GO:0008150|biological_process;GO:0010629|negative regulation of gene expression;GO:0016358|dendrite development;GO:0019216|regulation of lipid metabolic process;GO:0021591|ventricular system development;GO:0021756|striatum development;GO:0021766|hippocampus development;GO:0021987|cerebral cortex development;GO:0030534|adult behavior;GO:0030837|negative regulation of actin filament polymerization;GO:0032465|regulation of cytokinesis;GO:0033210|leptin-mediated signaling pathway;GO:0033365|protein localization to organelle;GO:0034260|negative regulation of GTPase activity;GO:0034454|microtubule anchoring at centrosome;GO:0035176|social behavior;GO:0035845|photoreceptor cell outer segment organization;GO:0038108|negative regulation of appetite by leptin-mediated signaling pathway;GO:0040018|positive regulation of multicellular organism growth;GO:0044321|response to leptin;GO:0045444|fat cell differentiation;GO:0045494|photoreceptor cell maintenance;GO:0045724|positive regulation of cilium assembly;GO:0046548|retinal rod cell development;GO:0048854|brain morphogenesis;GO:0051457|maintenance of protein location in nucleus;GO:0051492|regulation of stress fiber assembly;GO:0060271|cilium assembly;GO:0060296|regulation of cilium beat frequency involved in ciliary motility;GO:0060324|face development;GO:0060613|fat pad development;GO:0061512|protein localization to cilium;GO:0071539|protein localization to centrosome;GO:1902855|regulation of non-motile cilium assembly;GO:1903546|protein localization to photoreceptor outer segment;GO:1905515|non-motile cilium assembly;","GO:0000242|pericentriolar material;GO:0001750|photoreceptor outer segment;GO:0001917|photoreceptor inner segment;GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005813|centrosome;GO:0005814|centriole;GO:0005829|cytosol;GO:0005929|cilium;GO:0016020|membrane;GO:0031514|motile cilium;GO:0032391|photoreceptor connecting cilium;GO:0034451|centriolar satellite;GO:0034464|BBSome;GO:0035869|ciliary transition zone;GO:0036064|ciliary basal body;GO:0060170|ciliary membrane;GO:0097730|non-motile cilium;","GO:0003674|molecular_function;GO:0030674|protein binding, bridging;GO:0034452|dynactin binding;GO:0043014|alpha-tubulin binding;GO:0048487|beta-tubulin binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;","K16531","BBS4; Bardet-Biedl syndrome 4 protein"]
["ENSRNOG00000012701",394,32.71250425,1315,84.59452621,0.386697647,-1.370722109,{"v":3.284e-73,"d":"3.28E-73"},{"v":4.07733e-72,"d":"4.08E-72"},"down","yes","Map7","protein_coding","chr1:14910551-15037574:+","gi|310772205|ref|NP_001099740.2|",1617,0,"ensconsin isoform 1 [Rattus norvegicus]","gi|310772204|ref|NM_001106270.2|",1113,0,"Rattus norvegicus microtubule-associated protein 7 (Map7), transcript variant 1, mRNA","O88735",444,{"v":1E-136,"d":"1.00E-136"},"Ensconsin",".",".",".",".","pfam15402","Spc7_N","N-terminus of kinetochore NMS complex subunit Spc7.","GO:0000226|microtubule cytoskeleton organization;GO:0000902|cell morphogenesis;GO:0001578|microtubule bundle formation;GO:0006687|glycosphingolipid metabolic process;GO:0006970|response to osmotic stress;GO:0006997|nucleus organization;GO:0007281|germ cell development;GO:0007283|spermatogenesis;GO:0008283|cell proliferation;GO:0009566|fertilization;GO:0032526|response to retinoic acid;GO:0033327|Leydig cell differentiation;GO:0035265|organ growth;GO:0048872|homeostasis of number of cells;GO:0060009|Sertoli cell development;GO:0072659|protein localization to plasma membrane;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0015630|microtubule cytoskeleton;GO:0030424|axon;","GO:0005102|signaling receptor binding;","K10433","MAP7; microtubule-associated protein 7"]
["ENSRNOG00000051531",306,25.40615812,1126,72.4360734,0.35073903,-1.511530113,{"v":1.2989E-72,"d":"1.30E-72"},{"v":1.60334E-71,"d":"1.60E-71"},"down","yes","Ctu2","protein_coding","chr19:50539352-50544623:+","gi|50926101|gb|AAH79393.1|",2630,0,"LOC292069 protein, partial [Rattus norvegicus]","gi|50926100|gb|BC079393.1|",1682,0,"Rattus norvegicus similar to RIKEN cDNA 2310061F22, mRNA (cDNA clone IMAGE:7111976), partial cds","Q3B7U4",976,0,"Cytoplasmic tRNA 2-thiolation protein 2",".",".",".",".","pfam10288","DUF2392","Protein of unknown function (DUF2392). This is a family of proteins conserved from plants to humans. The function is not known. It carries a characteristic GRG sequence motif.","GO:0002098|tRNA wobble uridine modification;GO:0002143|tRNA wobble position uridine thiolation;GO:0008150|biological_process;GO:0032447|protein urmylation;GO:0034227|tRNA thio-modification;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0032991|protein-containing complex;","GO:0000049|tRNA binding;GO:0003674|molecular_function;GO:0016779|nucleotidyltransferase activity;GO:0016783|sulfurtransferase activity;","K14169","CTU2, NCS2; cytoplasmic tRNA 2-thiolation protein 2"]
["ENSRNOG00000020526",619,51.39350286,1752,112.7069277,0.455992404,-1.132918304,{"v":2.22685E-72,"d":"2.23E-72"},{"v":2.74349e-71,"d":"2.74E-71"},"down","yes","Mau2","protein_coding","chr16:19383492-19408727:+","gi|564388528|ref|XP_006252940.1|",3250,0,"PREDICTED: MAU2 chromatid cohesion factor homolog isoform X2 [Rattus norvegicus]","gi|672079606|ref|XM_006252878.2|",1974,0,"PREDICTED: Rattus norvegicus MAU2 sister chromatid cohesion factor (Mau2), transcript variant X2, mRNA","Q9D2X5",1147,0,"MAU2 chromatid cohesion factor homolog",".",".",".",".","pfam10345","Cohesin_load","Cohesin loading factor. Cohesin_load is a common cohesin loading factor protein that is conserved in fungi. It is associated with the cohesin complex and is required in G1 for cohesin binding to chromosomes but dispensable in G2 when cohesion has been established. It is referred to as both Ssl3, in pombe, and Scc4, in S.cerevisiae. It complexes with Mis4.","GO:0034088|maintenance of mitotic sister chromatid cohesion;GO:0071921|cohesin loading;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0016604|nuclear body;GO:0032116|SMC loading complex;GO:0090694|Scc2-Scc4 cohesin loading complex;","GO:0003690|double-stranded DNA binding;GO:0047485|protein N-terminus binding;","K11266","MAU2; MAternally affected uncoordination"]
["ENSRNOG00000011200",153,12.70307906,770,49.5344374,0.256449447,-1.963253637,{"v":1.18198E-71,"d":"1.18E-71"},{"v":1.44783e-70,"d":"1.45E-70"},"down","yes","Bhmt","protein_coding","chr2:24859873-24879742:-","gi|49259376|pdb|1UMY|A",2120,0,"Chain A, Bhmt From Rat Liver","gi|50926805|gb|BC078811.1|",1850,0,"Rattus norvegicus betaine-homocysteine methyltransferase, mRNA (cDNA clone MGC:93402 IMAGE:7130736), complete cds","O09171",816,0,"Betaine--homocysteine S-methyltransferase 1","BS_yitJ_1",96.3,{"v":7e-21,"d":"7.00E-21"},"COG0646","pfam02574","S-methyl_trans","Homocysteine S-methyltransferase. This is a family of related homocysteine S-methyltransferases enzymes: 5-methyltetrahydrofolate--homocysteine S-methyltransferases also known EC:2.1.1.13; Betaine--homocysteine S-methyltransferase (vitamin B12 dependent), EC:2.1.1.5,; and Homocysteine S-methyltransferase, EC:2.1.1.10,.","GO:0006479|protein methylation;GO:0006577|amino-acid betaine metabolic process;GO:0006579|amino-acid betaine catabolic process;GO:0009086|methionine biosynthetic process;GO:0010243|response to organonitrogen compound;GO:0032259|methylation;GO:0071267|L-methionine salvage;","GO:0005829|cytosol;GO:0032991|protein-containing complex;GO:0070062|extracellular exosome;","GO:0008168|methyltransferase activity;GO:0008270|zinc ion binding;GO:0044877|protein-containing complex binding;GO:0047150|betaine-homocysteine S-methyltransferase activity;","K00544","BHMT; betaine-homocysteine S-methyltransferase [EC:2.1.1.5]"]
["ENSRNOG00000023861",187,15.52598552,840,54.03756808,0.287318361,-1.799277902,{"v":1.49735E-69,"d":"1.50E-69"},{"v":1.77629e-68,"d":"1.78E-68"},"down","yes","Snap91","protein_coding","chr8:87738824-87852367:-","gi|564364792|ref|XP_006243556.1|",2792,0,"PREDICTED: clathrin coat assembly protein AP180 isoform X3 [Rattus norvegicus]","gi|13994176|ref|NM_031728.1|",2737,0,"Rattus norvegicus synaptosomal-associated protein 91 (Snap91), mRNA","Q61548",725,0,"Clathrin coat assembly protein AP180",".",".",".",".","pfam07651","ANTH","ANTH domain. AP180 is an endocytotic accessory proteins that has been implicated in the formation of clathrin-coated pits.  The domain is involved in phosphatidylinositol 4,5-bisphosphate binding and is a universal adaptor for nucleation of clathrin coats.","GO:0006900|vesicle budding from membrane;GO:0007163|establishment or maintenance of cell polarity;GO:0007268|chemical synaptic transmission;GO:0007269|neurotransmitter secretion;GO:0007409|axonogenesis;GO:0015031|protein transport;GO:0016185|synaptic vesicle budding from presynaptic endocytic zone membrane;GO:0030100|regulation of endocytosis;GO:0048268|clathrin coat assembly;GO:0048488|synaptic vesicle endocytosis;GO:0048666|neuron development;GO:0050772|positive regulation of axonogenesis;GO:0051223|regulation of protein transport;GO:0051899|membrane depolarization;GO:0072583|clathrin-dependent endocytosis;GO:1900242|regulation of synaptic vesicle endocytosis;GO:1900244|positive regulation of synaptic vesicle endocytosis;GO:1900275|negative regulation of phospholipase C activity;GO:1904006|negative regulation of phospholipase D activity;GO:1905445|positive regulation of clathrin coat assembly;GO:2000331|regulation of terminal button organization;GO:2000369|regulation of clathrin-dependent endocytosis;GO:2000809|positive regulation of synaptic vesicle clustering;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005905|clathrin-coated pit;GO:0008021|synaptic vesicle;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0030136|clathrin-coated vesicle;GO:0031313|extrinsic component of endosome membrane;GO:0042734|presynaptic membrane;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0043679|axon terminus;GO:0045211|postsynaptic membrane;GO:0048787|presynaptic active zone membrane;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098688|parallel fiber to Purkinje cell synapse;GO:0098830|presynaptic endosome;GO:0098833|presynaptic endocytic zone;GO:0098894|extrinsic component of presynaptic endocytic zone membrane;","GO:0000149|SNARE binding;GO:0000822|inositol hexakisphosphate binding;GO:0005515|protein binding;GO:0005545|1-phosphatidylinositol binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0019901|protein kinase binding;GO:0030276|clathrin binding;GO:0032050|clathrin heavy chain binding;GO:0035615|clathrin adaptor activity;GO:0042169|SH2 domain binding;GO:0043274|phospholipase binding;","K20043","SNAP91, AP180, CALM; clathrin coat assembly protein AP180"]
["ENSRNOG00000027006",323,26.81761135,1134,72.9507169,0.367612718,-1.443741414,{"v":2.05816e-68,"d":"2.06E-68"},{"v":2.42359e-67,"d":"2.42E-67"},"down","yes","ENSRNOG00000027006","protein_coding","chr10:78217761-78218895:+","gi|585645604|ref|XP_006882199.1|",1080,{"v":1E-142,"d":"1.00E-142"},"PREDICTED: heterogeneous nuclear ribonucleoprotein A3-like [Elephantulus edwardii]","gi|672045838|ref|XM_008761912.1|",824,0,"PREDICTED: Rattus norvegicus heterogeneous nuclear ribonucleoprotein A3 (Hnrnpa3), transcript variant X2, mRNA","P51991",384,{"v":2e-130,"d":"2.00E-130"},"Heterogeneous nuclear ribonucleoprotein A3",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.",".","GO:0005634|nucleus;","GO:0003723|RNA binding;",".","."]
["ENSRNOG00000008931",99,8.219639392,613,39.43455861,0.208437464,-2.262313487,{"v":2.24366E-68,"d":"2.24E-68"},{"v":2.63716e-67,"d":"2.64E-67"},"down","yes","Slc25a21","protein_coding","chr6:74203440-74702680:-","gi|19424330|ref|NP_598298.1|",1580,0,"mitochondrial 2-oxodicarboxylate carrier [Rattus norvegicus]","gi|58037555|ref|NM_133614.2|",2437,0,"Rattus norvegicus solute carrier family 25 member 21 (Slc25a21), mRNA","Q99JD3",613,0,"Mitochondrial 2-oxodicarboxylate carrier",".",".",".",".","pfam00153","Mito_carr","Mitochondrial carrier protein.","GO:1990550|mitochondrial alpha-ketoglutarate transmembrane transport;","GO:0005743|mitochondrial inner membrane;GO:0016021|integral component of membrane;","GO:0015139|alpha-ketoglutarate transmembrane transporter activity;","K15110","SLC25A21, ODC; solute carrier family 25 (mitochondrial 2-oxodicarboxylate transporter), member 21"]
["ENSRNOG00000046912",714,59.28103561,1896,121.9705108,0.486027608,-1.040889829,{"v":2.28075e-68,"d":"2.28E-68"},{"v":2.67584e-67,"d":"2.68E-67"},"down","yes","Nr1d2","protein_coding","chr15:7524257-7550553:+","gi|584277018|ref|NP_671743.2|",2855,0,"nuclear receptor subfamily 1 group D member 2 [Rattus norvegicus]","gi|584277017|ref|NM_147210.2|",4610,0,"Rattus norvegicus nuclear receptor subfamily 1, group D, member 2 (Nr1d2), mRNA","Q63504",1093,0,"Nuclear receptor subfamily 1 group D member 2",".",".",".",".","pfam00105","zf-C4","Zinc finger, C4 type (two domains). In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006355|regulation of transcription, DNA-templated;GO:0009755|hormone-mediated signaling pathway;GO:0019216|regulation of lipid metabolic process;GO:0030154|cell differentiation;GO:0030522|intracellular receptor signaling pathway;GO:0042752|regulation of circadian rhythm;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048512|circadian behavior;GO:0050727|regulation of inflammatory response;GO:0050728|negative regulation of inflammatory response;GO:0055088|lipid homeostasis;GO:0097009|energy homeostasis;GO:2001014|regulation of skeletal muscle cell differentiation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000987|proximal promoter sequence-specific DNA binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0004879|nuclear receptor activity;GO:0008270|zinc ion binding;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K08531","NR1D2; nuclear receptor subfamily 1 group D member 2"]
["ENSRNOG00000055648",540,44.83439668,1558,100.2268227,0.447329322,-1.160590765,{"v":4.83464e-67,"d":"4.83E-67"},{"v":5.55992e-66,"d":"5.56E-66"},"down","yes","ENSRNOG00000055648","protein_coding","chrX:151154979-151180577:-","gi|471434814|ref|NP_001264201.1|",1283,{"v":2e-168,"d":"2.00E-168"},"HAUS augmin-like complex subunit 7 [Rattus norvegicus]","gi|471434813|ref|NM_001277272.1|",929,0,"Rattus norvegicus HAUS augmin-like complex, subunit 7 (Haus7), mRNA","Q8BKT8",474,{"v":2E-160,"d":"2.00E-160"},"HAUS augmin-like complex subunit 7",".",".",".",".","pfam04258","Peptidase_A22B","Signal peptide peptidase. The members of this family are membrane proteins. In some proteins this region is found associated with pfam02225. This family corresponds with Merops subfamily A22B, the type example of which is signal peptide peptidase. There is a sequence-similarity relationship with pfam01080.","GO:0007098|centrosome cycle;GO:0051225|spindle assembly;","GO:0005813|centrosome;GO:0070652|HAUS complex;GO:1990498|mitotic spindle microtubule;","GO:0031996|thioesterase binding;GO:0051011|microtubule minus-end binding;","K16590","HAUS7, UIP1; HAUS augmin-like complex subunit 7"]
["ENSRNOG00000021176",624,51.80863617,1717,110.4553624,0.469045912,-1.092198949,{"v":5.2784e-67,"d":"5.28E-67"},{"v":6.05936e-66,"d":"6.06E-66"},"down","yes","Mtmr11","protein_coding","chr2:183723530-183732148:+","gi|300797762|ref|NP_001178025.1|",3354,0,"myotubularin-related protein 11 [Rattus norvegicus]","gi|300797761|ref|NM_001191096.1|",2638,0,"Rattus norvegicus myotubularin related protein 11 (Mtmr11), mRNA","Q3V1L6",1239,0,"Myotubularin-related protein 11",".",".",".",".","pfam06602","Myotub-related","Myotubularin-like phosphatase domain. This family represents the phosphatase domain within eukaryotic myotubularin-related proteins. Myotubularin is a dual-specific lipid phosphatase that dephosphorylates phosphatidylinositol 3-phosphate and phosphatidylinositol (3,5)-bi-phosphate. Mutations in gene encoding myotubularin-related proteins have been associated with disease.","GO:0046856|phosphatidylinositol dephosphorylation;","GO:0005737|cytoplasm;GO:0016020|membrane;","GO:0004438|phosphatidylinositol-3-phosphatase activity;","K18085","MTMR10_11_12; myotubularin-related protein 10/11/12"]
["ENSRNOG00000009296",287,23.82865157,1048,67.41829922,0.353444864,-1.500442919,{"v":5.34418e-67,"d":"5.34E-67"},{"v":6.12388e-66,"d":"6.12E-66"},"down","yes","Snapc1","protein_coding","chr6:92684752-92707746:+","gi|157820321|ref|NP_001101503.1|",1941,0,"snRNA-activating protein complex subunit 1 [Rattus norvegicus]","gi|171847085|gb|BC161969.1|",1706,0,"Rattus norvegicus small nuclear RNA activating complex, polypeptide 1, mRNA (cDNA clone MGC:187778 IMAGE:9028949), complete cds","Q8K0S9",673,0,"snRNA-activating protein complex subunit 1",".",".",".",".","pfam09808","SNAPc_SNAP43","Small nuclear RNA activating complex (SNAPc), subunit SNAP43. Members of this family are part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. They bind to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Furthermore, they also recruit TBP and BRF2 to the U6 snRNA TATA box.","GO:0042795|snRNA transcription by RNA polymerase II;GO:0042796|snRNA transcription by RNA polymerase III;","GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0019185|snRNA-activating protein complex;","GO:0043565|sequence-specific DNA binding;","K15208","SNAPC1; snRNA-activating protein complex subunit 1"]
["ENSRNOG00000032989",272,22.58325166,1012,65.10240344,0.34688814,-1.527457577,{"v":1.93984E-66,"d":"1.94E-66"},{"v":2.21097e-65,"d":"2.21E-65"},"down","yes","Lrrn4","protein_coding","chr3:120139410-120150831:-","gi|109470864|ref|XP_001081242.1|",3504,0,"PREDICTED: leucine-rich repeat neuronal protein 4 [Rattus norvegicus]","gi|672017367|ref|XM_001081242.4|",3172,0,"PREDICTED: Rattus norvegicus leucine rich repeat neuronal 4 (Lrrn4), mRNA","P59383",1113,0,"Leucine-rich repeat neuronal protein 4",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.","GO:0007616|long-term memory;GO:0008542|visual learning;","GO:0005887|integral component of plasma membrane;",".","K24493","LRRN4; leucine-rich repeat neuronal protein 4"]
["ENSRNOG00000037753",40,3.321066421,429,27.59775798,0.120338269,-3.054832586,{"v":2.37553e-66,"d":"2.38E-66"},{"v":2.69315e-65,"d":"2.69E-65"},"down","yes","Slc10a2","protein_coding","chr16:84374862-84409475:+","gi|8394281|ref|NP_058918.1|",1734,0,"ileal sodium/bile acid cotransporter [Rattus norvegicus]","gi|15011856|ref|NM_017222.2|",4145,0,"Rattus norvegicus solute carrier family 10 (sodium/bile acid cotransporter), member 2 (Slc10a2), mRNA","Q62633",672,0,"Ileal sodium/bile acid cotransporter","BS_yocS",113,{"v":8e-26,"d":"8.00E-26"},"COG0385","pfam01758","SBF","Sodium Bile acid symporter family. This family consists of Na+/bile acid co-transporters. These transmembrane proteins function in the liver in the uptake of bile acids from portal blood plasma a process mediated by the co-transport of Na+. Also in the family is ARC3 from S. cerevisiae, a putative transmembrane protein involved in resistance to arsenic compounds.","GO:0006814|sodium ion transport;GO:0008206|bile acid metabolic process;GO:0009617|response to bacterium;GO:0015721|bile acid and bile salt transport;GO:0055085|transmembrane transport;","GO:0000502|proteasome complex;GO:0005634|nucleus;GO:0005902|microvillus;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;","GO:0008508|bile acid:sodium symporter activity;","K14342","SLC10A2, ASBT; solute carrier family 10 (sodium/bile acid cotransporter), member 2"]
["ENSRNOG00000018782",324,26.90063801,1121,72.11442121,0.373027164,-1.422647404,{"v":3.28478e-66,"d":"3.28E-66"},{"v":3.70427e-65,"d":"3.70E-65"},"down","yes","Gmnn","protein_coding","chr17:40301808-40310054:+","gi|157820093|ref|NP_001099582.1|",1083,{"v":3e-145,"d":"3.00E-145"},"geminin [Rattus norvegicus]","gi|157820092|ref|NM_001106112.1|",1178,0,"Rattus norvegicus geminin, DNA replication inhibitor (Gmnn), mRNA","O88513",375,{"v":1e-128,"d":"1.00E-128"},"Geminin",".",".",".",".","pfam07412","Geminin","Geminin. This family contains the eukaryotic protein geminin (approximately 200 residues long). Geminin inhibits DNA replication by preventing the incorporation of MCM complex into prereplication complex, and is degraded during the mitotic phase of the cell cycle. It has been proposed that geminin inhibits DNA replication during S, G2, and M phases and that geminin destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.","GO:0006275|regulation of DNA replication;GO:0008156|negative regulation of DNA replication;GO:0009887|animal organ morphogenesis;GO:0035563|positive regulation of chromatin binding;GO:0045786|negative regulation of cell cycle;GO:0045892|negative regulation of transcription, DNA-templated;GO:0065003|protein-containing complex assembly;GO:0071163|DNA replication preinitiation complex assembly;GO:2000104|negative regulation of DNA-dependent DNA replication;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0003682|chromatin binding;GO:0003714|transcription corepressor activity;GO:0042826|histone deacetylase binding;","K10749","GMNN; geminin"]
["ENSRNOG00000053766",160,13.28426568,751,48.31215908,0.274967336,-1.862667846,{"v":2.61957E-65,"d":"2.62E-65"},{"v":2.92829e-64,"d":"2.93E-64"},"down","yes","Ramp3","protein_coding","chr14:81527385-81544902:+","gi|31377486|ref|NP_064485.2|",645,{"v":1E-79,"d":"1.00E-79"},"receptor activity-modifying protein 3 precursor [Rattus norvegicus]","gi|298891943|emb|FQ220789.1|",1221,0,"Rattus norvegicus TL0ADA41YK17 mRNA sequence","Q9JJ73",253,{"v":4e-81,"d":"4.00E-81"},"Receptor activity-modifying protein 3",".",".",".",".","pfam04901","RAMP","Receptor activity modifying family. The calcitonin-receptor-like receptor can function as either a calcitonin-gene-related peptide or an adrenomedullin receptor. The receptors function is modified by receptor-activity-modifying protein or RAMP. RAMPs are single-transmembrane-domain proteins.","GO:0001921|positive regulation of receptor recycling;GO:0006816|calcium ion transport;GO:0006886|intracellular protein transport;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0010628|positive regulation of gene expression;GO:0010739|positive regulation of protein kinase A signaling;GO:0010942|positive regulation of cell death;GO:0015031|protein transport;GO:0031623|receptor internalization;GO:0032870|cellular response to hormone stimulus;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0038041|cross-receptor inhibition within G protein-coupled receptor heterodimer;GO:0051897|positive regulation of protein kinase B signaling;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071392|cellular response to estradiol stimulus;GO:0072659|protein localization to plasma membrane;GO:0086103|G protein-coupled receptor signaling pathway involved in heart process;GO:0097647|amylin receptor signaling pathway;GO:1903078|positive regulation of protein localization to plasma membrane;GO:1904645|response to amyloid-beta;GO:1905665|positive regulation of calcium ion import across plasma membrane;GO:1990410|adrenomedullin receptor signaling pathway;","GO:0005764|lysosome;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0043235|receptor complex;GO:0150058|amylin receptor complex 3;GO:1903143|adrenomedullin receptor complex;","GO:0001605|adrenomedullin receptor activity;GO:0001664|G protein-coupled receptor binding;GO:0015026|coreceptor activity;GO:0097643|amylin receptor activity;","K08449","RAMP3; receptor activity modifying protein 3"]
["ENSRNOG00000028319",228,18.9300786,907,58.34770743,0.324435688,-1.62399557,{"v":3.9293E-65,"d":"3.93E-65"},{"v":4.35431E-64,"d":"4.35E-64"},"down","yes","Cryz","protein_coding","chr2:243552119-243579758:+","gi|58865938|ref|NP_001012183.1|",1561,0,"quinone oxidoreductase [Rattus norvegicus]","gi|672044561|ref|XM_006233520.2|",1869,0,"PREDICTED: Rattus norvegicus crystallin, zeta (quinone reductase) (Cryz), transcript variant X1, mRNA","Q6AYT0",605,0,"Quinone oxidoreductase","BH0935",163,{"v":6e-44,"d":"6.00E-44"},"COG0604","pfam00107","ADH_zinc_N","Zinc-binding dehydrogenase.","GO:0008150|biological_process;GO:0042178|xenobiotic catabolic process;GO:0051289|protein homotetramerization;","GO:0005829|cytosol;","GO:0003730|mRNA 3'-UTR binding;GO:0003960|NADPH:quinone reductase activity;GO:0008270|zinc ion binding;GO:0042802|identical protein binding;GO:0070402|NADPH binding;","K00344","qor, CRYZ; NADPH:quinone reductase [EC:1.6.5.5]"]
["ENSRNOG00000058003",259,21.50390508,971,62.46485548,0.344256061,-1.538446042,{"v":1.7739E-64,"d":"1.77E-64"},{"v":1.94221e-63,"d":"1.94E-63"},"down","yes","Spon1","protein_coding","chr1:167928972-168228226:+","gi|78070801|gb|AAI07656.1|",3916,0,"Spondin 1, extracellular matrix protein [Rattus norvegicus]","gi|78070800|gb|BC107655.1|",4091,0,"Rattus norvegicus spondin 1, extracellular matrix protein, mRNA (cDNA clone MGC:124557 IMAGE:7935103), complete cds","P35446",1511,0,"Spondin-1",".",".",".",".","pfam06468","Spond_N","Spondin_N. This conserved region is found at the in the N-terminal half of several Spondin proteins. Spondins are involved in patterning axonal growth trajectory through either inhibiting or promoting adhesion of embryonic nerve cells.","GO:0007155|cell adhesion;GO:0010954|positive regulation of protein processing;GO:0032092|positive regulation of protein binding;GO:1902430|negative regulation of amyloid-beta formation;GO:1902993|positive regulation of amyloid precursor protein catabolic process;","GO:0005576|extracellular region;GO:0031012|extracellular matrix;","GO:0046872|metal ion binding;GO:0050693|LBD domain binding;","K24427","SPON1; spondin-1"]
["ENSRNOG00000059715",436,36.19962399,1335,85.88113498,0.421508449,-1.246366546,{"v":2.19386e-64,"d":"2.19E-64"},{"v":2.38974E-63,"d":"2.39E-63"},"down","yes","Cc2d2a","protein_coding","chr14:67351353-67435949:-","gi|392333084|ref|XP_003752787.1|",7751,0,"PREDICTED: coiled-coil and C2 domain-containing protein 2A isoform X1 [Rattus norvegicus]","gi|672028003|ref|XM_006221784.2|",5448,0,"PREDICTED: Rattus norvegicus coiled-coil and C2 domain containing 2A (Cc2d2a), transcript variant X1, mRNA","Q8CFW7",2840,0,"Coiled-coil and C2 domain-containing protein 2A",".",".",".",".","pfam15625","CC2D2AN-C2","CC2D2A N-terminal C2 domain. Many ciliary proteins are involved in ciliogenesis and implicated for ciliophathies. A recent study has shown that many of them contain various new versions of C2 domains which are predicted to mediate membrane localizations for Y-shaped linkers of transition zone of cilia. This is the first C2 domain of ciliary CC2D2A proteins which also have another C2 domain (CC2D2AC-C2) and a new inactive transglutaminase-like peptidase domain (CC2D2A-TGL).","GO:0001822|kidney development;GO:0001843|neural tube closure;GO:0007224|smoothened signaling pathway;GO:0007368|determination of left/right symmetry;GO:0007507|heart development;GO:0008150|biological_process;GO:0035082|axoneme assembly;GO:0043010|camera-type eye development;GO:0044458|motile cilium assembly;GO:0060271|cilium assembly;GO:1904491|protein localization to ciliary transition zone;GO:1905515|non-motile cilium assembly;GO:1990403|embryonic brain development;","GO:0005575|cellular_component;GO:0035869|ciliary transition zone;GO:0036038|MKS complex;","GO:0003674|molecular_function;","K19352","CC2D2A; coiled-coil and C2 domain-containing protein 2A"]
["ENSRNOG00000000442",538,44.66834336,1522,97.91092692,0.456214079,-1.132217125,{"v":4.6582e-63,"d":"4.66E-63"},{"v":4.93947e-62,"d":"4.94E-62"},"down","yes","Notch4","protein_coding","chr20:4160445-4184465:-","gi|50657364|ref|NP_001002827.1|",8976,0,"neurogenic locus notch homolog protein 4 precursor [Rattus norvegicus]","gi|50657363|ref|NM_001002827.1|",6483,0,"Rattus norvegicus notch 4 (Notch4), mRNA","P31695",3155,0,"Neurogenic locus notch homolog protein 4","FN0178",91.7,{"v":2e-18,"d":"2.00E-18"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001569|branching involved in blood vessel morphogenesis;GO:0001763|morphogenesis of a branching structure;GO:0001837|epithelial to mesenchymal transition;GO:0001886|endothelial cell morphogenesis;GO:0001944|vasculature development;GO:0007219|Notch signaling pathway;GO:0008593|regulation of Notch signaling pathway;GO:0030879|mammary gland development;GO:0032880|regulation of protein localization;GO:0042060|wound healing;GO:0045446|endothelial cell differentiation;GO:0045602|negative regulation of endothelial cell differentiation;GO:0045746|negative regulation of Notch signaling pathway;GO:0045766|positive regulation of angiogenesis;GO:0048845|venous blood vessel morphogenesis;GO:0060354|negative regulation of cell adhesion molecule production;GO:0070613|regulation of protein processing;GO:1903849|positive regulation of aorta morphogenesis;GO:2000048|negative regulation of cell-cell adhesion mediated by cadherin;","GO:0005634|nucleus;GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0031410|cytoplasmic vesicle;","GO:0005112|Notch binding;GO:0005509|calcium ion binding;GO:0038023|signaling receptor activity;","K20996","NOTCH4; Notch 4"]
["ENSRNOG00000025184",470,39.02253045,1391,89.48363952,0.436085643,-1.197316602,{"v":5.18544e-63,"d":"5.19E-63"},{"v":5.48944e-62,"d":"5.49E-62"},"down","yes","Prss35","protein_coding","chr8:87714966-87731009:+","gi|672062704|ref|XP_008764668.1|",2097,0,"PREDICTED: inactive serine protease 35 isoform X1 [Rattus norvegicus]","gi|56676349|ref|NM_001008560.1|",3095,0,"Rattus norvegicus protease, serine, 35 (Prss35), mRNA","Q5R212",809,0,"Inactive serine protease 35",".",".",".",".","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;","GO:0005576|extracellular region;","GO:0004252|serine-type endopeptidase activity;",".","."]
["ENSRNOG00000008936",139,11.54070581,684,44.00201972,0.262276729,-1.930838286,{"v":1.66911e-62,"d":"1.67E-62"},{"v":1.74672e-61,"d":"1.75E-61"},"down","yes","Map3k6","protein_coding","chr5:145440346-145452212:+","gi|157816917|ref|NP_001101379.1|",5894,0,"mitogen-activated protein kinase kinase kinase 6 [Rattus norvegicus]","gi|157816916|ref|NM_001107909.1|",4339,0,"Rattus norvegicus mitogen-activated protein kinase kinase kinase 6 (Map3k6), mRNA","Q9WTR2",2156,0,"Mitogen-activated protein kinase kinase kinase 6",".",".",".",".","pfam13281","DUF4071","Domain of unknown function (DUF4071). This domain is found at the N-terminus of many serine-threonine kinase-like proteins.","GO:0000165|MAPK cascade;GO:0006468|protein phosphorylation;GO:0033554|cellular response to stress;",".","GO:0000287|magnesium ion binding;GO:0004672|protein kinase activity;GO:0004709|MAP kinase kinase kinase activity;GO:0005524|ATP binding;","K04425","MAP3K6, ASK2; mitogen-activated protein kinase kinase kinase 6 [EC:2.7.11.25]"]
["ENSRNOG00000008943",327,27.14971799,1099,70.69915157,0.384017593,-1.380755689,{"v":3.7355E-62,"d":"3.74E-62"},{"v":3.87746e-61,"d":"3.88E-61"},"down","yes","Penk","protein_coding","chr5:17183806-17189129:-","gi|564350204|ref|XP_006237897.1|",1433,0,"PREDICTED: proenkephalin-A isoform X1 [Rattus norvegicus]","gi|564350203|ref|XM_006237835.1|",1282,0,"PREDICTED: Rattus norvegicus proenkephalin (Penk), transcript variant X1, mRNA","P04094",556,0,"Proenkephalin-A",".",".",".",".","pfam01160","Opiods_neuropep","Vertebrate endogenous opioids neuropeptide.","GO:0001649|osteoblast differentiation;GO:0001662|behavioral fear response;GO:0001666|response to hypoxia;GO:0001964|startle response;GO:0002118|aggressive behavior;GO:0007218|neuropeptide signaling pathway;GO:0007268|chemical synaptic transmission;GO:0007568|aging;GO:0007600|sensory perception;GO:0007626|locomotory behavior;GO:0009314|response to radiation;GO:0009617|response to bacterium;GO:0009636|response to toxic substance;GO:0014009|glial cell proliferation;GO:0019233|sensory perception of pain;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0034599|cellular response to oxidative stress;GO:0035094|response to nicotine;GO:0035641|locomotory exploration behavior;GO:0043278|response to morphine;GO:0045471|response to ethanol;GO:0051592|response to calcium ion;GO:0051867|general adaptation syndrome, behavioral process;GO:0071305|cellular response to vitamin D;GO:0071320|cellular response to cAMP;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0071871|response to epinephrine;GO:0098586|cellular response to virus;GO:0099538|synaptic signaling via neuropeptide;GO:2000987|positive regulation of behavioral fear response;","GO:0005576|extracellular region;GO:0005886|plasma membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0032280|symmetric synapse;GO:0034466|chromaffin granule lumen;GO:0034592|synaptic vesicle lumen;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0043679|axon terminus;GO:0070852|cell body fiber;GO:0099013|neuronal dense core vesicle lumen;","GO:0001515|opioid peptide activity;GO:0003674|molecular_function;GO:0031628|opioid receptor binding;","K18832","PENK; proenkephalin A"]
["ENSRNOG00000006368",294,24.40983819,1029,66.19602089,0.368750838,-1.439281766,{"v":5.72124e-62,"d":"5.72E-62"},{"v":5.91945e-61,"d":"5.92E-61"},"down","yes","Lrrn3","protein_coding","chr6:58489010-58520330:-","gi|51980290|gb|AAH81791.1|",3594,0,"Leucine rich repeat neuronal 3 [Rattus norvegicus]","gi|13540674|ref|NM_030856.1|",3032,0,"Rattus norvegicus leucine rich repeat neuronal 3 (Lrrn3), mRNA","Q9ESY6",1382,0,"Leucine-rich repeat neuronal protein 3","alr0124_1",58.5,8e-08,"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0001934|positive regulation of protein phosphorylation;GO:0051965|positive regulation of synapse assembly;","GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030131|clathrin adaptor complex;GO:0031012|extracellular matrix;","GO:0044877|protein-containing complex binding;","K24492","LRRN1_2_3; leucine-rich repeat neuronal protein 1/2/3"]
["ENSRNOG00000011771",672,55.79391587,1760,113.2215712,0.492785211,-1.020969135,{"v":1.14802E-61,"d":"1.15E-61"},{"v":1.17826E-60,"d":"1.18E-60"},"down","yes","Ptp4a1","protein_coding","chr9:33214208-33221964:-","gi|148682476|gb|EDL14423.1|",944,{"v":1E-119,"d":"1.00E-119"},"protein tyrosine phosphatase 4a1, isoform CRA_b, partial [Mus musculus]","gi|827836142|ref|NM_031579.3|",1357,0,"Rattus norvegicus protein tyrosine phosphatase type IVA, member 1 (Ptp4a1), mRNA","Q78EG7",364,{"v":1E-119,"d":"1.00E-119"},"Protein tyrosine phosphatase type IVA 1","DR2161",56.2,4e-08,"COG2453","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0030335|positive regulation of cell migration;GO:0035335|peptidyl-tyrosine dephosphorylation;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005769|early endosome;GO:0005783|endoplasmic reticulum;GO:0005819|spindle;GO:0009898|cytoplasmic side of plasma membrane;","GO:0004725|protein tyrosine phosphatase activity;GO:0008138|protein tyrosine/serine/threonine phosphatase activity;","K18041","PTP4A; protein tyrosine phosphatase type IVA [EC:3.1.3.48]"]
["ENSRNOG00000016351",345,28.64419788,1129,72.62906471,0.39439029,-1.342304063,{"v":3.49407e-61,"d":"3.49E-61"},{"v":3.56323e-60,"d":"3.56E-60"},"down","yes","Frrs1","protein_coding","chr2:204823025-204895540:+","gi|672016242|ref|XP_008773478.1|",3035,0,"PREDICTED: ferric-chelate reductase 1 isoform X1 [Rattus norvegicus]","gi|672016241|ref|XM_008775256.1|",1886,0,"PREDICTED: Rattus norvegicus ferric-chelate reductase 1 (Frrs1), transcript variant X1, mRNA","Q8K385",1062,0,"Ferric-chelate reductase 1",".",".",".",".","pfam02014","Reeler","Reeler domain.","GO:0006879|cellular iron ion homeostasis;","GO:0016021|integral component of membrane;","GO:0016722|oxidoreductase activity, oxidizing metal ions;",".","."]
["ENSRNOG00000003927",103,8.551746034,576,37.05433239,0.23078937,-2.115351318,{"v":2.3448e-59,"d":"2.34E-59"},{"v":2.34631e-58,"d":"2.35E-58"},"down","yes","Cd55","protein_coding","chr13:41857395-41885831:-","gi|625186847|ref|XP_007614661.1|",1977,0,"PREDICTED: complement decay-accelerating factor isoform X2 [Cricetulus griseus]","gi|38511537|gb|BC061869.1|",1396,0,"Rattus norvegicus Cd55 molecule, mRNA (cDNA clone MGC:72267 IMAGE:5598916), complete cds","Q61475",449,{"v":7e-145,"d":"7.00E-145"},"Complement decay-accelerating factor, GPI-anchored",".",".",".",".","pfam05109","Herpes_BLLF1","Herpes virus major outer envelope glycoprotein (BLLF1). This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralizing antibodies in vivo.","GO:0002456|T cell mediated immunity;GO:0002726|positive regulation of T cell cytokine production;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007283|spermatogenesis;GO:0030449|regulation of complement activation;GO:0030450|regulation of complement activation, classical pathway;GO:0031664|regulation of lipopolysaccharide-mediated signaling pathway;GO:0043086|negative regulation of catalytic activity;GO:0043434|response to peptide hormone;GO:0045916|negative regulation of complement activation;GO:0045959|negative regulation of complement activation, classical pathway;GO:0046718|viral entry into host cell;GO:0060137|maternal process involved in parturition;GO:1903659|regulation of complement-dependent cytotoxicity;GO:2000516|positive regulation of CD4-positive, alpha-beta T cell activation;GO:2000563|positive regulation of CD4-positive, alpha-beta T cell proliferation;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016324|apical plasma membrane;GO:0045121|membrane raft;GO:0097225|sperm midpiece;","GO:0001618|virus receptor activity;GO:0004857|enzyme inhibitor activity;GO:0008289|lipid binding;","K04006","DAF, CD55; decay accelerating factor"]
["ENSRNOG00000007002",13,1.079346587,300,19.29913146,0.05592721,-4.160305816,{"v":7.03729e-59,"d":"7.04E-59"},{"v":6.97631e-58,"d":"6.98E-58"},"down","yes","Lif","protein_coding","chr14:79134574-79140482:+","gi|162287188|ref|NP_071532.2|",1079,{"v":9e-135,"d":"9.00E-135"},"leukemia inhibitory factor precursor [Rattus norvegicus]","gi|672076932|ref|XM_006251364.2|",2002,0,"PREDICTED: Rattus norvegicus leukemia inhibitory factor (Lif), transcript variant X1, mRNA","P17777",410,{"v":2E-132,"d":"2.00E-132"},"Leukemia inhibitory factor",".",".",".",".","pfam01291","LIF_OSM","LIF / OSM family.","GO:0001974|blood vessel remodeling;GO:0006955|immune response;GO:0007260|tyrosine phosphorylation of STAT protein;GO:0007566|embryo implantation;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0010628|positive regulation of gene expression;GO:0010976|positive regulation of neuron projection development;GO:0016525|negative regulation of angiogenesis;GO:0019827|stem cell population maintenance;GO:0030324|lung development;GO:0031100|animal organ regeneration;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0033141|positive regulation of peptidyl-serine phosphorylation of STAT protein;GO:0033630|positive regulation of cell adhesion mediated by integrin;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0043410|positive regulation of MAPK cascade;GO:0045595|regulation of cell differentiation;GO:0045651|positive regulation of macrophage differentiation;GO:0045835|negative regulation of meiotic nuclear division;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046697|decidualization;GO:0046888|negative regulation of hormone secretion;GO:0048286|lung alveolus development;GO:0048644|muscle organ morphogenesis;GO:0048666|neuron development;GO:0048708|astrocyte differentiation;GO:0048711|positive regulation of astrocyte differentiation;GO:0048861|leukemia inhibitory factor signaling pathway;GO:0048863|stem cell differentiation;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0051461|positive regulation of corticotropin secretion;GO:0060041|retina development in camera-type eye;GO:0060135|maternal process involved in female pregnancy;GO:0060290|transdifferentiation;GO:0060426|lung vasculature development;GO:0060463|lung lobe morphogenesis;GO:0060707|trophoblast giant cell differentiation;GO:0060708|spongiotrophoblast differentiation;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0072108|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0072307|regulation of metanephric nephron tubule epithelial cell differentiation;GO:1900182|positive regulation of protein localization to nucleus;GO:1901676|positive regulation of histone H3-K27 acetylation;GO:1903025|regulation of RNA polymerase II regulatory region sequence-specific DNA binding;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005829|cytosol;","GO:0005102|signaling receptor binding;GO:0005125|cytokine activity;GO:0005146|leukemia inhibitory factor receptor binding;GO:0008083|growth factor activity;","K05419","LIF; leukemia inhibitory factor"]
["ENSRNOG00000007447",338,28.06301126,1098,70.63482113,0.397297124,-1.331709747,{"v":7.44631e-59,"d":"7.45E-59"},{"v":7.37035E-58,"d":"7.37E-58"},"down","yes","Pla2g4b","protein_coding","chr3:107005489-107013853:+","gi|167900429|ref|NP_001101234.2|",3993,0,"cytosolic phospholipase A2 beta [Rattus norvegicus]","gi|167900428|ref|NM_001107764.2|",2812,0,"Rattus norvegicus phospholipase A2 group IVB (Pla2g4b), mRNA","P0C871",1425,0,"Cytosolic phospholipase A2 beta",".",".",".",".","pfam01735","PLA2_B","Lysophospholipase catalytic domain. This family consists of Lysophospholipase / phospholipase B EC:3.1.1.5 and cytosolic phospholipase A2 EC:3.1.4 which also has a C2 domain pfam00168. Phospholipase B enzymes catalyse the release of fatty acids from lysophsopholipids and are capable in vitro of hydrolysing all phospholipids extractable form yeast cells. Cytosolic phospholipase A2 associates with natural membranes in response to physiological increases in Ca2+ and selectively hydrolyses arachidonyl phospholipids, the aligned region corresponds the the carboxy-terminal Ca2+-independent catalytic domain of the protein as discussed in.","GO:0036151|phosphatidylcholine acyl-chain remodeling;GO:0036152|phosphatidylethanolamine acyl-chain remodeling;GO:0046475|glycerophospholipid catabolic process;","GO:0005743|mitochondrial inner membrane;GO:0005829|cytosol;GO:0031901|early endosome membrane;","GO:0004622|lysophospholipase activity;GO:0004623|phospholipase A2 activity;GO:0005509|calcium ion binding;GO:0005544|calcium-dependent phospholipid binding;GO:0008970|phospholipase A1 activity;GO:0047498|calcium-dependent phospholipase A2 activity;","K16342","PLA2G4, CPLA2; cytosolic phospholipase A2 [EC:3.1.1.4]"]
["ENSRNOG00000029450",500,41.51333026,1409,90.6415874,0.457994299,-1.126598455,{"v":4.63981e-58,"d":"4.64E-58"},{"v":4.54325e-57,"d":"4.54E-57"},"down","yes","Adgrb1","protein_coding","chr7:106404958-106476902:+","gi|294345428|ref|NP_001164068.2|",7384,0,"brain-specific angiogenesis inhibitor 1 precursor [Rattus norvegicus]","gi|294345427|ref|NM_001170597.2|",5511,0,"Rattus norvegicus brain-specific angiogenesis inhibitor 1 (Bai1), mRNA","C0HL12",2848,0,"Adhesion G protein-coupled receptor B1",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0006910|phagocytosis, recognition;GO:0006911|phagocytosis, engulfment;GO:0007166|cell surface receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007399|nervous system development;GO:0007517|muscle organ development;GO:0010596|negative regulation of endothelial cell migration;GO:0016525|negative regulation of angiogenesis;GO:0031397|negative regulation of protein ubiquitination;GO:0042177|negative regulation of protein catabolic process;GO:0043277|apoptotic cell clearance;GO:0043652|engulfment of apoptotic cell;GO:0045087|innate immune response;GO:0048167|regulation of synaptic plasticity;GO:0050829|defense response to Gram-negative bacterium;GO:0051963|regulation of synapse assembly;GO:0051965|positive regulation of synapse assembly;GO:0098974|postsynaptic actin cytoskeleton organization;GO:1901741|positive regulation of myoblast fusion;GO:1903428|positive regulation of reactive oxygen species biosynthetic process;","GO:0001891|phagocytic cup;GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005925|focal adhesion;GO:0014069|postsynaptic density;GO:0030425|dendrite;GO:0043197|dendritic spine;GO:0048471|perinuclear region of cytoplasm;GO:0098978|glutamatergic synapse;GO:0099055|integral component of postsynaptic membrane;","GO:0001530|lipopolysaccharide binding;GO:0001786|phosphatidylserine binding;GO:0004888|transmembrane signaling receptor activity;GO:0004930|G protein-coupled receptor activity;GO:0005515|protein binding;GO:0030165|PDZ domain binding;","K04596","ADGRB1, BAI1; adhesion G protein-coupled receptor B1"]
["ENSRNOG00000006670",346,28.72722454,1106,71.14946463,0.403758829,-1.308434286,{"v":9.95134e-58,"d":"9.95E-58"},{"v":9.72935e-57,"d":"9.73E-57"},"down","yes","Rai2","protein_coding","chrX:32948656-33011264:-","gi|157818399|ref|NP_001102786.1|",1291,{"v":4E-165,"d":"4.00E-165"},"retinoic acid-induced protein 2 [Rattus norvegicus]","gi|157818398|ref|NM_001109316.1|",2564,0,"Rattus norvegicus retinoic acid induced 2 (Rai2), mRNA",".",".",".",".",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.",".",".",".",".","."]
["ENSRNOG00000010078",113,9.382012639,590,37.95495853,0.247188062,-2.016319026,{"v":3.09746e-57,"d":"3.10E-57"},{"v":3.00539e-56,"d":"3.01E-56"},"down","yes","Spag1","protein_coding","chr7:67361477-67421368:+","gi|58865802|ref|NP_001012116.1|",4448,0,"sperm-associated antigen 1 [Rattus norvegicus]","gi|58865801|ref|NM_001012116.1|",3650,0,"Rattus norvegicus sperm associated antigen 1 (Spag1), mRNA","Q5U2X2",1717,0,"Sperm-associated antigen 1",".",".",".",".","pfam13877","RPAP3_C","Potential Monad-binding region of RPAP3. This domain is found at the C-terminus of RNA-polymerase II-associated proteins. These proteins bind to Monad and are involved in regulating apoptosis.   They contain TPR-repeats towards the N_terminus.","GO:0007338|single fertilization;GO:0070286|axonemal dynein complex assembly;","GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0005525|GTP binding;GO:0016787|hydrolase activity;","K19870","SPAG1; sperm-associated antigen 1"]
["ENSRNOG00000006615",418,34.7051441,1244,80.0270651,0.433667586,-1.205338482,{"v":3.97842e-57,"d":"3.98E-57"},{"v":3.84848e-56,"d":"3.85E-56"},"down","yes","Mtap","protein_coding","chr5:103873020-103939406:+","gi|148699009|gb|EDL30956.1|",1559,0,"methylthioadenosine phosphorylase, isoform CRA_b, partial [Mus musculus]","gi|672053093|ref|XM_006238382.2|",1695,0,"PREDICTED: Rattus norvegicus methylthioadenosine phosphorylase (Mtap), transcript variant X1, mRNA","Q9CQ65",578,0,"S-methyl-5'-thioadenosine phosphorylase","PAB2264",245,{"v":1e-75,"d":"1.00E-75"},"COG0005","pfam01048","PNP_UDP_1","Phosphorylase superfamily. Members of this family include: purine nucleoside phosphorylase (PNP) Uridine phosphorylase (UdRPase) 5'-methylthioadenosine phosphorylase (MTA phosphorylase)","GO:0006166|purine ribonucleoside salvage;GO:0019509|L-methionine salvage from methylthioadenosine;GO:0032259|methylation;GO:0033574|response to testosterone;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0017061|S-methyl-5-thioadenosine phosphorylase activity;","K00772","mtaP, MTAP; 5'-methylthioadenosine phosphorylase [EC:2.4.2.28]"]
["ENSRNOG00000027491",511,42.42662353,1419,91.28489178,0.464771582,-1.105406237,{"v":9.46868e-57,"d":"9.47E-57"},{"v":9.10432e-56,"d":"9.10E-56"},"down","yes","Vldlr","protein_coding","chr1:224814377-224845920:+","gi|293597511|ref|NP_037287.2|",4306,0,"very low-density lipoprotein receptor precursor [Rattus norvegicus]","gi|293597510|ref|NM_013155.2|",3411,0,"Rattus norvegicus very low density lipoprotein receptor (Vldlr), mRNA","P98166",1665,0,"Very low-density lipoprotein receptor",".",".",".",".","pfam00057","Ldl_recept_a","Low-density lipoprotein receptor domain class A.","GO:0001666|response to hypoxia;GO:0006869|lipid transport;GO:0006898|receptor-mediated endocytosis;GO:0007166|cell surface receptor signaling pathway;GO:0007507|heart development;GO:0007584|response to nutrient;GO:0008203|cholesterol metabolic process;GO:0009410|response to xenobiotic stimulus;GO:0009725|response to hormone;GO:0021517|ventral spinal cord development;GO:0021987|cerebral cortex development;GO:0032496|response to lipopolysaccharide;GO:0032869|cellular response to insulin stimulus;GO:0034436|glycoprotein transport;GO:0034447|very-low-density lipoprotein particle clearance;GO:0038026|reelin-mediated signaling pathway;GO:0042149|cellular response to glucose starvation;GO:0045860|positive regulation of protein kinase activity;GO:0048813|dendrite morphogenesis;GO:0061098|positive regulation of protein tyrosine kinase activity;GO:0071222|cellular response to lipopolysaccharide;GO:0071347|cellular response to interleukin-1;GO:0071456|cellular response to hypoxia;GO:1900006|positive regulation of dendrite development;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0005905|clathrin-coated pit;GO:0009986|cell surface;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0034361|very-low-density lipoprotein particle;GO:0043235|receptor complex;GO:0045177|apical part of cell;GO:0048471|perinuclear region of cytoplasm;","GO:0005509|calcium ion binding;GO:0030229|very-low-density lipoprotein particle receptor activity;GO:0030296|protein tyrosine kinase activator activity;GO:0034185|apolipoprotein binding;GO:0034189|very-low-density lipoprotein particle binding;GO:0038024|cargo receptor activity;GO:0038025|reelin receptor activity;GO:0048306|calcium-dependent protein binding;","K20053","VLDLR; very low-density lipoprotein receptor"]
["ENSRNOG00000054272",638,52.97100941,1652,106.2738839,0.498438633,-1.004512201,{"v":1.65157e-56,"d":"1.65E-56"},{"v":1.58088E-55,"d":"1.58E-55"},"down","yes","Dhx57","protein_coding","chr6:14725303-14776321:+","gi|300793704|ref|NP_001178836.1|",6889,0,"putative ATP-dependent RNA helicase DHX57 [Rattus norvegicus]","gi|695917248|ref|NM_001191907.2|",4674,0,"Rattus norvegicus DEAH-box helicase 57 (Dhx57), mRNA","Q6P5D3",2541,0,"Putative ATP-dependent RNA helicase DHX57",".",".",".",".","pfam04408","HA2","Helicase associated domain (HA2). This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.",".","GO:0005622|intracellular;","GO:0003723|RNA binding;GO:0004386|helicase activity;GO:0005524|ATP binding;GO:0046872|metal ion binding;","K13026","DHX57; ATP-dependent RNA helicase DHX57 [EC:3.6.4.13]"]
["ENSRNOG00000008515",139,11.54070581,649,41.75045438,0.276421083,-1.855060439,{"v":2.20837e-56,"d":"2.21E-56"},{"v":2.10755E-55,"d":"2.11E-55"},"down","yes","Tmem45b","protein_coding","chr8:29865278-29910453:-","gi|74271857|ref|NP_001028239.1|",1477,0,"transmembrane protein 45B [Rattus norvegicus]","gi|74271856|ref|NM_001033067.1|",3446,0,"Rattus norvegicus transmembrane protein 45b (Tmem45b), mRNA","Q497B2",573,0,"Transmembrane protein 45B",".",".",".",".","pfam04819","DUF716","Family of unknown function (DUF716). This family is equally distributed in both metazoa and plants. Annotation associated with a member from Nicotiana tabacum suggest that it may be involved in response to viral attack in plants. However, no clear function has been assigned to this family.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000030715",366,30.38775775,1134,72.9507169,0.416551873,-1.26343193,{"v":4.14807e-56,"d":"4.15E-56"},{"v":3.92936E-55,"d":"3.93E-55"},"down","yes","Cfh","protein_coding","chr13:51511828-51613838:-","gi|77861917|ref|NP_569093.2|",6580,0,"complement factor H precursor [Rattus norvegicus]","gi|77861916|ref|NM_130409.2|",4250,0,"Rattus norvegicus complement factor H (Cfh), mRNA","P06909",2063,0,"Complement factor H",".",".",".",".","pfam00084","Sushi","Sushi domain (SCR repeat).","GO:0001525|angiogenesis;GO:0001780|neutrophil homeostasis;GO:0001822|kidney development;GO:0001905|activation of membrane attack complex;GO:0002021|response to dietary excess;GO:0002251|organ or tissue specific immune response;GO:0002434|immune complex clearance;GO:0003406|retinal pigment epithelium development;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0006956|complement activation;GO:0006957|complement activation, alternative pathway;GO:0007005|mitochondrion organization;GO:0007601|visual perception;GO:0008340|determination of adult lifespan;GO:0010467|gene expression;GO:0016064|immunoglobulin mediated immune response;GO:0030449|regulation of complement activation;GO:0032042|mitochondrial DNA metabolic process;GO:0032835|glomerulus development;GO:0034097|response to cytokine;GO:0035886|vascular smooth muscle cell differentiation;GO:0046034|ATP metabolic process;GO:0046530|photoreceptor cell differentiation;GO:0046548|retinal rod cell development;GO:0050905|neuromuscular process;GO:0051216|cartilage development;GO:0051640|organelle localization;GO:0060041|retina development in camera-type eye;GO:0060348|bone development;GO:0070301|cellular response to hydrogen peroxide;GO:0070487|monocyte aggregation;GO:0070527|platelet aggregation;GO:0071222|cellular response to lipopolysaccharide;GO:0071346|cellular response to interferon-gamma;GO:0090594|inflammatory response to wounding;GO:0097273|creatinine homeostasis;GO:0140053|mitochondrial gene expression;GO:1903659|regulation of complement-dependent cytotoxicity;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0030424|axon;GO:0043025|neuronal cell body;","GO:0001851|complement component C3b binding;GO:0003674|molecular_function;GO:0008201|heparin binding;GO:0042802|identical protein binding;GO:0043395|heparan sulfate proteoglycan binding;","K04004","CFH, HF1; complement factor H"]
["ENSRNOG00000007637",174,14.44663893,727,46.76822856,0.30889857,-1.694794902,{"v":9.48892e-56,"d":"9.49E-56"},{"v":8.94884e-55,"d":"8.95E-55"},"down","yes","Acer2","protein_coding","chr5:101391885-101442614:+","gi|157817955|ref|NP_001101413.1|",1444,0,"alkaline ceramidase 2 [Rattus norvegicus]","gi|157817954|ref|NM_001107943.1|",5147,0,"Rattus norvegicus alkaline ceramidase 2 (Acer2), mRNA","Q8VD53",553,0,"Alkaline ceramidase 2",".",".",".",".","pfam05875","Ceramidase","Ceramidase. This family consists of several ceramidases. Ceramidases are enzymes involved in regulating cellular levels of ceramides, sphingoid bases, and their phosphates, EC:3.5.1.23.","GO:0001953|negative regulation of cell-matrix adhesion;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006974|cellular response to DNA damage stimulus;GO:0008150|biological_process;GO:0008284|positive regulation of cell proliferation;GO:0010506|regulation of autophagy;GO:0010942|positive regulation of cell death;GO:0030330|DNA damage response, signal transduction by p53 class mediator;GO:0032526|response to retinoic acid;GO:0033629|negative regulation of cell adhesion mediated by integrin;GO:0042981|regulation of apoptotic process;GO:0046512|sphingosine biosynthetic process;GO:0046514|ceramide catabolic process;GO:0071466|cellular response to xenobiotic stimulus;GO:0090285|negative regulation of protein glycosylation in Golgi;","GO:0005575|cellular_component;GO:0005794|Golgi apparatus;GO:0030173|integral component of Golgi membrane;","GO:0003674|molecular_function;GO:0017040|N-acylsphingosine amidohydrolase activity;GO:0071633|dihydroceramidase activity;GO:0102121|ceramidase activity;","K01441","ACER1_2, ASAH3; alkaline ceramidase [EC:3.5.1.23]"]
["ENSRNOG00000016550",570,47.3251965,1517,97.58927473,0.484942599,-1.044114105,{"v":2.45167e-55,"d":"2.45E-55"},{"v":2.2885e-54,"d":"2.29E-54"},"down","yes","Dclk2","protein_coding","chr2:172208706-172338250:-","gi|564337259|ref|XP_006232747.1|",3093,0,"PREDICTED: serine/threonine-protein kinase DCLK2 isoform X7 [Rattus norvegicus]","gi|672043021|ref|XR_351805.2|",3912,0,"PREDICTED: Rattus norvegicus doublecortin-like kinase 2 (Dclk2), transcript variant X7, misc_RNA","Q5MPA9",1180,0,"Serine/threonine-protein kinase DCLK2",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0000226|microtubule cytoskeleton organization;GO:0006468|protein phosphorylation;GO:0018105|peptidyl-serine phosphorylation;GO:0021766|hippocampus development;GO:0021860|pyramidal neuron development;GO:0035556|intracellular signal transduction;GO:1900181|negative regulation of protein localization to nucleus;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;","GO:0004672|protein kinase activity;GO:0005524|ATP binding;GO:0008017|microtubule binding;","K08805","DCLK1_2; doublecortin-like kinase 1/2 [EC:2.7.11.1]"]
["ENSRNOG00000009729",356,29.55749115,1108,71.27812551,0.414678289,-1.269935579,{"v":2.72877e-55,"d":"2.73E-55"},{"v":2.54345e-54,"d":"2.54E-54"},"down","yes","Ubp1","protein_coding","chr8:113869979-113915625:+","gi|300797079|ref|NP_001178748.1|",2781,0,"upstream-binding protein 1 [Rattus norvegicus]","gi|300797078|ref|NM_001191819.1|",2456,0,"Rattus norvegicus upstream binding protein 1 (LBP-1a) (Ubp1), mRNA","Q811S7",1064,0,"Upstream-binding protein 1",".",".",".",".","pfam04516","CP2","CP2 transcription factor. This family represents a conserved region in the CP2 transcription factor family.","GO:0001525|angiogenesis;GO:0006357|regulation of transcription by RNA polymerase II;GO:0032897|negative regulation of viral transcription;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837|sequence-specific double-stranded DNA binding;","K09275","TFCP2; transcription factor CP2 and related proteins"]
["ENSRNOG00000007202",108,8.966879337,563,36.2180367,0.247580492,-2.014030454,{"v":1.2755E-54,"d":"1.28E-54"},{"v":1.18198E-53,"d":"1.18E-53"},"down","yes","Sema3d","protein_coding","chr4:22316779-22505930:-","gi|157277992|ref|NP_001098103.1|",4147,0,"semaphorin-3D [Rattus norvegicus]","gi|157277991|ref|NM_001104633.1|",4912,0,"Rattus norvegicus semaphorin 3D (Sema3d), mRNA","Q8BH34",1566,0,"Semaphorin-3D",".",".",".",".","pfam01403","Sema","Sema domain. The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and human plexin A-3.","GO:0001755|neural crest cell migration;GO:0007411|axon guidance;GO:0030335|positive regulation of cell migration;GO:0048843|negative regulation of axon extension involved in axon guidance;GO:0050919|negative chemotaxis;GO:0071526|semaphorin-plexin signaling pathway;","GO:0005615|extracellular space;GO:0005887|integral component of plasma membrane;","GO:0030215|semaphorin receptor binding;GO:0045499|chemorepellent activity;","K06840","SEMA3; semaphorin 3"]
["ENSRNOG00000022937",74,6.143972879,469,30.17097551,0.203638523,-2.295917591,{"v":1.16944E-53,"d":"1.17E-53"},{"v":1.06822e-52,"d":"1.07E-52"},"down","yes","Bpifc","protein_coding","chr7:17861007-17905919:+","gi|157818469|ref|NP_001100243.1|",2684,0,"BPI fold-containing family C protein precursor [Rattus norvegicus]","gi|157818468|ref|NM_001106773.1|",2158,0,"Rattus norvegicus BPI fold containing family C (Bpifc), mRNA","Q8C186",945,0,"BPI fold-containing family C protein",".",".",".",".","pfam01273","LBP_BPI_CETP","LBP / BPI / CETP family, N-terminal domain. The N and C terminal domains of the LBP/BPI/CETP family are structurally similar.",".","GO:0005615|extracellular space;","GO:0008289|lipid binding;","K25377","BPIFC; BPI fold-containing family C"]
["ENSRNOG00000019718",56,4.649492989,417,26.82579272,0.173321737,-2.528475495,{"v":2.15946e-53,"d":"2.16E-53"},{"v":1.96692e-52,"d":"1.97E-52"},"down","yes","Galnt15","protein_coding","chr16:7227271-7267014:+","gi|392333503|ref|XP_003752912.1|",3313,0,"PREDICTED: polypeptide N-acetylgalactosaminyltransferase 15 isoform X1 [Rattus norvegicus]","gi|672029069|ref|XM_003752864.3|",2746,0,"PREDICTED: Rattus norvegicus polypeptide N-acetylgalactosaminyltransferase 15 (Galnt15), transcript variant X1, mRNA","Q9D2N8",1095,0,"Polypeptide N-acetylgalactosaminyltransferase 15",".",".",".",".","pfam00535","Glycos_transf_2","Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.","GO:0006486|protein glycosylation;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;GO:0030133|transport vesicle;","GO:0004653|polypeptide N-acetylgalactosaminyltransferase activity;GO:0030246|carbohydrate binding;GO:0046872|metal ion binding;","K00710","GALNT; polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41]"]
["ENSRNOG00000008694",166,13.78242565,694,44.6453241,0.308709275,-1.695679265,{"v":2.44379E-53,"d":"2.44E-53"},{"v":2.21958e-52,"d":"2.22E-52"},"down","yes","Miox","protein_coding","chr7:120405031-120407537:+","gi|56090638|ref|NP_665714.2|",1415,0,"inositol oxygenase [Rattus norvegicus]","gi|298906354|emb|FQ219187.1|",1010,0,"Rattus norvegicus TL0ABA47YA19 mRNA sequence","Q9QXN4",549,0,"Inositol oxygenase",".",".",".",".","pfam05153","DUF706","Family of unknown function (DUF706). Family of uncharacterized eukaryotic function. Some members have a described putative function, but a common theme is not evident.","GO:0019310|inositol catabolic process;","GO:0005737|cytoplasm;GO:0016234|inclusion body;","GO:0004033|aldo-keto reductase (NADP) activity;GO:0008199|ferric iron binding;GO:0016651|oxidoreductase activity, acting on NAD(P)H;GO:0016701|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen;GO:0050113|inositol oxygenase activity;GO:0050661|NADP binding;","K00469","MIOX; inositol oxygenase [EC:1.13.99.1]"]
["ENSRNOG00000018246",565,46.9100632,1490,95.8523529,0.489399183,-1.030916402,{"v":2.68059e-53,"d":"2.68E-53"},{"v":2.42776e-52,"d":"2.43E-52"},"down","yes","Tdp2","protein_coding","chr17:40228947-40240313:-","gi|149031531|gb|EDL86498.1|",1838,0,"similar to putative TRAF and TNF receptor associated protein, isoform CRA_c [Rattus norvegicus]","gi|77917591|ref|NM_001034947.1|",1917,0,"Rattus norvegicus tyrosyl-DNA phosphodiesterase 2 (Tdp2), mRNA","Q3T1H5",709,0,"Tyrosyl-DNA phosphodiesterase 2",".",".",".",".","pfam03372","Exo_endo_phos","Endonuclease/Exonuclease/phosphatase family. This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins EC:4.2.99.18, DNase I proteins EC:3.1.21.1, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56, Sphingomyelinase EC:3.1.4.12 and Nocturnin.","GO:0006302|double-strand break repair;GO:0048666|neuron development;GO:0090305|nucleic acid phosphodiester bond hydrolysis;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0016235|aggresome;GO:0016604|nuclear body;GO:0016605|PML body;","GO:0000287|magnesium ion binding;GO:0003697|single-stranded DNA binding;GO:0004518|nuclease activity;GO:0030145|manganese ion binding;GO:0036317|tyrosyl-RNA phosphodiesterase activity;GO:0070260|5'-tyrosyl-DNA phosphodiesterase activity;","K19619","TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]"]
["ENSRNOG00000011039",422,35.03725074,1213,78.03282152,0.449006585,-1.15519149,{"v":3.19893e-52,"d":"3.20E-52"},{"v":2.84879e-51,"d":"2.85E-51"},"down","yes","Gch1","protein_coding","chr15:20402527-20437698:-","gi|13242245|ref|NP_077332.1|",1290,{"v":2e-168,"d":"2.00E-168"},"GTP cyclohydrolase 1 precursor [Rattus norvegicus]","gi|13542897|gb|BC005643.1|",1365,0,"Mus musculus GTP cyclohydrolase 1, mRNA (cDNA clone MGC:12095 IMAGE:3709238), complete cds","P22288",501,{"v":5e-170,"d":"5.00E-170"},"GTP cyclohydrolase 1","alr5287",260,{"v":7e-79,"d":"7.00E-79"},"COG0302","pfam01227","GTP_cyclohydroI","GTP cyclohydrolase I. This family includes GTP cyclohydrolase enzymes and a family of related bacterial proteins.","GO:0006729|tetrahydrobiopterin biosynthetic process;GO:0008217|regulation of blood pressure;GO:0010460|positive regulation of heart rate;GO:0014916|regulation of lung blood pressure;GO:0032496|response to lipopolysaccharide;GO:0034341|response to interferon-gamma;GO:0034612|response to tumor necrosis factor;GO:0035998|7,8-dihydroneopterin 3'-triphosphate biosynthetic process;GO:0042311|vasodilation;GO:0042416|dopamine biosynthetic process;GO:0042559|pteridine-containing compound biosynthetic process;GO:0045776|negative regulation of blood pressure;GO:0046654|tetrahydrofolate biosynthetic process;GO:0048265|response to pain;GO:0050884|neuromuscular process controlling posture;GO:0051000|positive regulation of nitric-oxide synthase activity;GO:0051066|dihydrobiopterin metabolic process;GO:0065003|protein-containing complex assembly;GO:2000121|regulation of removal of superoxide radicals;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0031410|cytoplasmic vesicle;GO:0031965|nuclear membrane;GO:0032991|protein-containing complex;","GO:0003924|GTPase activity;GO:0003934|GTP cyclohydrolase I activity;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0005525|GTP binding;GO:0008270|zinc ion binding;GO:0030742|GTP-dependent protein binding;GO:0031369|translation initiation factor binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0044877|protein-containing complex binding;GO:0051019|mitogen-activated protein kinase binding;","K01495","GCH1, folE; GTP cyclohydrolase IA [EC:3.5.4.16]"]
["ENSRNOG00000029861",486,40.35095702,1334,85.81680454,0.470198783,-1.088657291,{"v":3.38664e-52,"d":"3.39E-52"},{"v":3.01175e-51,"d":"3.01E-51"},"down","yes","Gsta2","protein_coding","chr8:79184322-79196798:-","gi|51036637|ref|NP_058709.2|",1006,{"v":2e-129,"d":"2.00E-129"},"glutathione S-transferase alpha-1 [Rattus norvegicus]","gi|50927556|gb|BC078706.1|",896,0,"Rattus norvegicus glutathione S-transferase A2, mRNA (cDNA clone MGC:93118 IMAGE:7128611), complete cds","P00502",392,{"v":7e-131,"d":"7.00E-131"},"Glutathione S-transferase alpha-1",".",".",".",".","pfam00043","GST_C","Glutathione S-transferase, C-terminal domain. GST conjugates reduced glutathione to a variety of targets including S-crystallin from squid, the eukaryotic elongation factor 1-gamma, the HSP26 family of stress-related proteins and auxin-regulated proteins in plants. Stringent starvation proteins in Escherichia coli are also included in the alignment but are not known to have GST activity.     The glutathione molecule binds in a cleft between N and C-terminal domains. The catalytically important residues are proposed to reside in the N-terminal domain. In plants, GSTs are encoded by a large gene family (48 GST genes in Arabidopsis) and can be divided into the phi, tau, theta, zeta, and lambda classes.","GO:0006693|prostaglandin metabolic process;GO:0006749|glutathione metabolic process;GO:0006805|xenobiotic metabolic process;GO:0007568|aging;GO:0009617|response to bacterium;GO:0030855|epithelial cell differentiation;GO:0035634|response to stilbenoid;GO:0042178|xenobiotic catabolic process;GO:0098869|cellular oxidant detoxification;GO:1901687|glutathione derivative biosynthetic process;","GO:0005829|cytosol;","GO:0004364|glutathione transferase activity;GO:0004769|steroid delta-isomerase activity;GO:0035731|dinitrosyl-iron complex binding;GO:0042803|protein homodimerization activity;GO:0043295|glutathione binding;","K00799","GST, gst; glutathione S-transferase [EC:2.5.1.18]"]
["ENSRNOG00000049351",37,3.071986439,352,22.64431424,0.135662595,-2.881905097,{"v":7.46716e-52,"d":"7.47E-52"},{"v":6.56751e-51,"d":"6.57E-51"},"down","yes","Nat8l","protein_coding","chr14:76756077-76763411:-","gi|134288912|ref|NP_001001985.3|",1097,{"v":2e-135,"d":"2.00E-135"},"N-acetylaspartate synthetase [Mus musculus]","gi|300794295|ref|NM_001191681.1|",3279,0,"Rattus norvegicus N-acetyltransferase 8-like (Nat8l), mRNA","D3ZVU9",425,{"v":4E-136,"d":"4.00E-136"},"N-acetylaspartate synthetase","YPO3444",56.6,5e-08,"COG0454","pfam00583","Acetyltransf_1","Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.","GO:0051586|positive regulation of dopamine uptake involved in synaptic transmission;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0030867|rough endoplasmic reticulum membrane;GO:0031966|mitochondrial membrane;","GO:0008080|N-acetyltransferase activity;GO:0017188|aspartate N-acetyltransferase activity;","K18309","NAT8L; aspartate N-acetyltransferase [EC:2.3.1.17]"]
["ENSRNOG00000027002",548,45.49860997,1443,92.8288223,0.490134517,-1.028750345,{"v":1.67901e-51,"d":"1.68E-51"},{"v":1.46264e-50,"d":"1.46E-50"},"down","yes","Mast4","protein_coding","chr2:33894436-34483723:-","gi|672015368|ref|XP_008773279.1|",10778,0,"PREDICTED: microtubule-associated serine/threonine-protein kinase 4 isoform X1 [Rattus norvegicus]","gi|672041354|ref|XM_008760704.1|",8470,0,"PREDICTED: Rattus norvegicus microtubule associated serine/threonine kinase family member 4 (Mast4), transcript variant X1, mRNA","Q811L6",4127,0,"Microtubule-associated serine/threonine-protein kinase 4",".",".",".",".","pfam08926","DUF1908","Domain of unknown function (DUF1908). This domain is found in a set of hypothetical/structural eukaryotic proteins.",".",".",".","K08789","MAST; microtubule-associated serine/threonine kinase [EC:2.7.11.1]"]
["ENSRNOG00000018752",82,6.808186163,479,30.81427989,0.220942569,-2.178256685,{"v":1.85217E-51,"d":"1.85E-51"},{"v":1.60692e-50,"d":"1.61E-50"},"down","yes","ENSRNOG00000018752","protein_coding","chr1:201507859-201517605:+","gi|533139327|ref|XP_005384395.1|",1468,0,"PREDICTED: cardiotrophin-like cytokine factor 1 isoform X1 [Chinchilla lanigera]","gi|76563943|ref|NM_207615.2|",1602,0,"Rattus norvegicus cardiotrophin-like cytokine factor 1 (Clcf1), mRNA","Q9QZM3",464,{"v":1e-158,"d":"1.00E-158"},"Cardiotrophin-like cytokine factor 1",".",".",".",".","pfam06875","PRF","Plethodontid receptivity factor PRF. This family consists of several plethodontid receptivity factor (PRF) proteins which seem to be specific to Plethodon jordani (Jordan's salamander). PRF is a courtship pheromone produced by males increase female receptivity.","GO:0002639|positive regulation of immunoglobulin production;GO:0007166|cell surface receptor signaling pathway;GO:0007259|JAK-STAT cascade;GO:0008284|positive regulation of cell proliferation;GO:0030183|B cell differentiation;GO:0030890|positive regulation of B cell proliferation;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0043524|negative regulation of neuron apoptotic process;GO:0048295|positive regulation of isotype switching to IgE isotypes;GO:0048711|positive regulation of astrocyte differentiation;","GO:0005576|extracellular region;GO:0097058|CRLF-CLCF1 complex;GO:0097059|CNTFR-CLCF1 complex;","GO:0005102|signaling receptor binding;GO:0005125|cytokine activity;GO:0005127|ciliary neurotrophic factor receptor binding;","K05421","CLCF1, BSF3, CLC; cardiotrophin-like cytokine factor 1"]
["ENSRNOG00000017766",425,35.28633072,1206,77.58250845,0.454823277,-1.136622005,{"v":1.20692e-50,"d":"1.21E-50"},{"v":1.02759E-49,"d":"1.03E-49"},"down","yes","Ca12","protein_coding","chr8:67274359-67330440:+","gi|564364325|ref|XP_006243372.1|",1817,0,"PREDICTED: carbonic anhydrase 12 isoform X1 [Rattus norvegicus]","gi|672062154|ref|XM_006243310.2|",3749,0,"PREDICTED: Rattus norvegicus carbonic anyhydrase 12 (Car12), transcript variant X1, mRNA","Q8CI85",678,0,"Carbonic anhydrase 12","BH0360",104,{"v":3E-23,"d":"3.00E-23"},"COG3338","pfam00194","Carb_anhydrase","Eukaryotic-type carbonic anhydrase.","GO:0006730|one-carbon metabolic process;GO:0055064|chloride ion homeostasis;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004089|carbonate dehydratase activity;GO:0008270|zinc ion binding;GO:0016836|hydro-lyase activity;","K01672","CA; carbonic anhydrase [EC:4.2.1.1]"]
["ENSRNOG00000064680",310,25.73826476,980,63.04382942,0.408259857,-1.292440378,{"v":2.01886e-50,"d":"2.02E-50"},{"v":1.70751E-49,"d":"1.71E-49"},"down","yes","Gpihbp1","protein_coding","chr7:107285654-107288702:+","gi|194474096|ref|NP_001124019.1|",1037,{"v":2e-133,"d":"2.00E-133"},"glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 precursor [Rattus norvegicus]","gi|194474095|ref|NM_001130547.1|",2080,0,"Rattus norvegicus glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 (Gpihbp1), mRNA","Q9D1N2",318,{"v":6E-102,"d":"6.00E-102"},"Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1",".",".",".",".","pfam15240","Pro-rich","Proline-rich. This family includes several eukaryotic proline-rich proteins.",".",".",".",".","."]
["ENSRNOG00000047761",470,39.02253045,1289,82.92193482,0.470593583,-1.087446446,{"v":2.08045E-50,"d":"2.08E-50"},{"v":1.75728e-49,"d":"1.76E-49"},"down","yes","Zfp326","protein_coding","chr14:3941958-3980384:-","gi|672027704|ref|XP_008762849.1|",2303,0,"PREDICTED: DBIRD complex subunit ZNF326-like isoform X1, partial [Rattus norvegicus]","gi|269784643|ref|NM_018759.2|",1530,0,"Mus musculus zinc finger protein 326 (Zfp326), transcript variant 1, mRNA","O88291",845,0,"DBIRD complex subunit ZNF326",".",".",".",".","pfam04988","AKAP95","A-kinase anchoring protein 95 (AKAP95). A-kinase (or PKA)-anchoring protein AKAP95 is implicated in mitotic chromosome condensation by acting as a targeting molecule for the condensin complex. The protein contains two zinc fingers which are thought to mediate the binding of AKAP95 to DNA.","GO:0032784|regulation of DNA-templated transcription, elongation;GO:0043484|regulation of RNA splicing;GO:0045893|positive regulation of transcription, DNA-templated;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0016363|nuclear matrix;GO:0043231|intracellular membrane-bounded organelle;GO:0044609|DBIRD complex;","GO:0000993|RNA polymerase II complex binding;GO:0003677|DNA binding;GO:0008270|zinc ion binding;","K13204","ZNF326; zinc finger protein 326"]
["ENSRNOG00000049629",203,16.85441209,757,48.69814171,0.346099697,-1.530740417,{"v":2.62605E-50,"d":"2.63E-50"},{"v":2.21228e-49,"d":"2.21E-49"},"down","yes","Reep2","protein_coding","chr18:26438346-26447161:+","gi|532025987|ref|XP_005355979.1|",1223,{"v":2E-160,"d":"2.00E-160"},"PREDICTED: receptor expression-enhancing protein 2 isoform X1 [Microtus ochrogaster]","gi|114158667|ref|NM_001048047.1|",1751,0,"Rattus norvegicus receptor accessory protein 2 (Reep2), mRNA","Q8VCD6",461,{"v":2e-156,"d":"2.00E-156"},"Receptor expression-enhancing protein 2","SPBC30D10.09c",65.9,{"v":3E-11,"d":"3.00E-11"},"COG5052","pfam03134","TB2_DP1_HVA22","TB2/DP1, HVA22 family. This family includes members from a wide variety of eukaryotes. It includes the TB2/DP1 (deleted in polyposis) protein, which in humans is deleted in severe forms of familial adenomatous polyposis, an autosomal dominant oncological inherited disease. The family also includes the plant protein of known similarity to TB2/DP1, the HVA22 abscisic acid-induced protein, which is thought to be a regulatory protein.","GO:0032386|regulation of intracellular transport;GO:0032596|protein transport into membrane raft;GO:0050913|sensory perception of bitter taste;GO:0050916|sensory perception of sweet taste;GO:0071786|endoplasmic reticulum tubular network organization;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005881|cytoplasmic microtubule;GO:0005887|integral component of plasma membrane;","GO:0031883|taste receptor binding;","K17338","REEP1_2_3_4; receptor expression-enhancing protein 1/2/3/4"]
["ENSRNOG00000065430",416,34.53909078,1186,76.29589969,0.452699174,-1.14337542,{"v":2.71011e-50,"d":"2.71E-50"},{"v":2.28009E-49,"d":"2.28E-49"},"down","yes","Zfp958","protein_coding","chr12:3953455-3975514:+","gi|218505767|ref|NP_001136230.1|",2257,0,"zinc finger protein 878 [Rattus norvegicus]","gi|218505766|ref|NM_001142758.1|",1511,0,"Rattus norvegicus zinc finger protein 958 (Zfp958), mRNA","E9QAG8",579,0,"Zinc finger protein 431",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000001275",313,25.98734474,984,63.30115117,0.410535105,-1.284422502,{"v":3.77051e-50,"d":"3.77E-50"},{"v":3.16392e-49,"d":"3.16E-49"},"down","yes","Tmem184a","protein_coding","chr12:14822898-14832065:+","gi|564378401|ref|XP_006249000.1|",2016,0,"PREDICTED: transmembrane protein 184A isoform X2 [Rattus norvegicus]","gi|672072001|ref|XM_006248938.2|",2022,0,"PREDICTED: Rattus norvegicus transmembrane protein 184A (Tmem184a), transcript variant X1, mRNA","Q4QQS1",733,0,"Transmembrane protein 184A",".",".",".",".","pfam03619","Solute_trans_a","Organic solute transporter Ostalpha. This family is a transmembrane organic solute transport protein. In vertebrates these proteins form a complex with Ostbeta, and function as bile transporters. In plants they may transport brassinosteroid-like compounds and act as regulators of cell death.","GO:0006810|transport;GO:0018992|germ-line sex determination;GO:0032880|regulation of protein localization;GO:0051046|regulation of secretion;","GO:0005768|endosome;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030658|transport vesicle membrane;GO:0030659|cytoplasmic vesicle membrane;GO:0030667|secretory granule membrane;GO:0031901|early endosome membrane;GO:0048471|perinuclear region of cytoplasm;","GO:0005215|transporter activity;GO:0008201|heparin binding;",".","."]
["ENSRNOG00000019416",499,41.4303036,1334,85.81680454,0.482776116,-1.05057379,{"v":2.35079e-49,"d":"2.35E-49"},{"v":1.93951e-48,"d":"1.94E-48"},"down","yes","ENSRNOG00000019416","protein_coding","chr1:79850014-79871249:-","gi|672035156|ref|XP_008757184.1|",3130,0,"PREDICTED: zinc finger protein 61 isoform X1 [Rattus norvegicus]","gi|672035155|ref|XM_008758962.1|",2406,0,"PREDICTED: Rattus norvegicus zinc finger protein 61 (Zfp61), transcript variant X1, mRNA","Q9NYT6",573,0,"Zinc finger protein 226",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;",".","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0046872|metal ion binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSRNOG00000046662",541,44.91742334,1408,90.57725696,0.495901784,-1.011873679,{"v":5.42347e-49,"d":"5.42E-49"},{"v":4.45735e-48,"d":"4.46E-48"},"down","yes","ENSRNOG00000046662","protein_coding","chrX:134258125-134309617:+","gi|569010022|ref|XP_006528039.1|",4155,0,"PREDICTED: protein DDX26B isoform X1 [Mus musculus]","gi|569010023|ref|XM_006527977.1|",2486,0,"PREDICTED: Mus musculus DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B (Ddx26b), transcript variant X2, mRNA","Q8BND4",1514,0,"Integrator complex subunit 6-like",".",".",".",".","pfam15300","INT_SG_DDX_CT_C","INTS6/SAGE1/DDX26B/CT45 C-terminus. This domain is found at the C-terminus of integrator complex subunit 6 (INTS6), sarcoma antigen 1 (SAGE1), protein DDX26B (DDX26B) and members of the cancer/testis antigen family 45.",".","GO:0016021|integral component of membrane;",".","K13180","DDX26B; ATP-dependent RNA helicase DDX26B [EC:3.6.4.-]"]
["ENSRNOG00000059579",438,36.36567731,1213,78.03282152,0.466030532,-1.101503619,{"v":1.67065e-48,"d":"1.67E-48"},{"v":1.35048E-47,"d":"1.35E-47"},"down","yes","Gpt2","protein_coding","chr19:21517621-21560610:-","gi|589917004|ref|XP_006971817.1|",2755,0,"PREDICTED: alanine aminotransferase 2 isoform X1 [Peromyscus maniculatus bairdii]","gi|672084459|ref|XM_008772406.1|",3649,0,"PREDICTED: Rattus norvegicus glutamic pyruvate transaminase (alanine aminotransferase) 2 (Gpt2), transcript variant X2, mRNA","Q8BGT5",1039,0,"Alanine aminotransferase 2","YDR111c",425,{"v":5e-134,"d":"5.00E-134"},"COG0436","pfam00155","Aminotran_1_2","Aminotransferase class I and II.","GO:0006103|2-oxoglutarate metabolic process;GO:0009058|biosynthetic process;GO:0032869|cellular response to insulin stimulus;GO:0033574|response to testosterone;GO:0042594|response to starvation;GO:0042851|L-alanine metabolic process;GO:0045722|positive regulation of gluconeogenesis;","GO:0005615|extracellular space;GO:0005739|mitochondrion;","GO:0004021|L-alanine:2-oxoglutarate aminotransferase activity;GO:0030170|pyridoxal phosphate binding;","K00814","GPT, ALT; alanine transaminase [EC:2.6.1.2]"]
["ENSRNOG00000020525",191,15.85809216,718,46.18925462,0.343328601,-1.54233805,{"v":2.55148e-48,"d":"2.55E-48"},{"v":2.05471E-47,"d":"2.05E-47"},"down","yes","Col5a3","protein_coding","chr8:19304571-19349853:-","gi|672061032|ref|XP_008764201.1|",1927,0,"PREDICTED: collagen alpha-3(V) chain isoform X1 [Rattus norvegicus]","gi|672061031|ref|XM_008765979.1|",6117,0,"PREDICTED: Rattus norvegicus collagen, type V, alpha 3 (Col5a3), transcript variant X1, mRNA","P25940",499,{"v":1e-144,"d":"1.00E-144"},"Collagen alpha-3(V) chain",".",".",".",".","pfam01410","COLFI","Fibrillar collagen C-terminal domain. Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1 alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.","GO:0007160|cell-matrix adhesion;GO:0030198|extracellular matrix organization;","GO:0005588|collagen type V trimer;GO:0005615|extracellular space;GO:0031012|extracellular matrix;GO:0062023|collagen-containing extracellular matrix;","GO:0005201|extracellular matrix structural constituent;GO:0008201|heparin binding;GO:0043394|proteoglycan binding;","K19721","COL5AS; collagen type V/XI/XXIV/XXVII, alpha"]
["ENSRNOG00000013436",173,14.36361227,676,43.48737621,0.330293835,-1.598178052,{"v":6.32151e-48,"d":"6.32E-48"},{"v":5.03995e-47,"d":"5.04E-47"},"down","yes","Pde7b","protein_coding","chr1:15182704-15492900:-","gi|672033732|ref|XP_008756813.1|",2685,0,"PREDICTED: cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [Rattus norvegicus]","gi|672033731|ref|XM_008758591.1|",2073,0,"PREDICTED: Rattus norvegicus phosphodiesterase 7B (Pde7b), transcript variant X1, mRNA","Q9QXQ1",850,0,"cAMP-specific 3',5'-cyclic phosphodiesterase 7B",".",".",".",".","pfam00233","PDEase_I","3'5'-cyclic nucleotide phosphodiesterase.","GO:0007165|signal transduction;GO:0019933|cAMP-mediated signaling;",".","GO:0004114|3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0004115|3',5'-cyclic-AMP phosphodiesterase activity;GO:0046872|metal ion binding;","K18436","PDE7; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7 [EC:3.1.4.53]"]
["ENSRNOG00000007937",509,42.26057021,1338,86.07412629,0.490978788,-1.026267398,{"v":1.0615E-47,"d":"1.06E-47"},{"v":8.44195e-47,"d":"8.44E-47"},"down","yes","Krit1","protein_coding","chr4:30299203-30333359:-","gi|157820449|ref|NP_001102088.1|",3904,0,"krev interaction trapped protein 1 [Rattus norvegicus]","gi|157820448|ref|NM_001108618.1|",3045,0,"Rattus norvegicus KRIT1, ankyrin repeat containing (Krit1), mRNA","Q6S5J6",1484,0,"Krev interaction trapped protein 1","FN0178",53.1,2e-06,"COG0666","pfam00373","FERM_M","FERM central domain. This domain is the central structural domain of the FERM domain.","GO:0001937|negative regulation of endothelial cell proliferation;GO:0008150|biological_process;GO:0010596|negative regulation of endothelial cell migration;GO:0016525|negative regulation of angiogenesis;GO:0032092|positive regulation of protein binding;GO:0045454|cell redox homeostasis;GO:2000114|regulation of establishment of cell polarity;GO:2000352|negative regulation of endothelial cell apoptotic process;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0032991|protein-containing complex;","GO:0003674|molecular_function;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0008017|microtubule binding;","K17705","KRIT1; Krev interaction trapped protein 1"]
["ENSRNOG00000045738",140,11.62373247,598,38.46960203,0.302153697,-1.726645501,{"v":2.36597e-47,"d":"2.37E-47"},{"v":1.86769e-46,"d":"1.87E-46"},"down","yes","Ak4","protein_coding","chr5:116039616-116098618:+","gi|564351830|ref|XP_006238507.1|",1185,{"v":2e-148,"d":"2.00E-148"},"PREDICTED: adenylate kinase 4, mitochondrial isoform X1 [Rattus norvegicus]","gi|672053113|ref|XM_006238445.2|",3755,0,"PREDICTED: Rattus norvegicus adenylate kinase 4 (Ak4), transcript variant X1, mRNA","Q9WUS0",455,{"v":7e-149,"d":"7.00E-149"},"Adenylate kinase 4, mitochondrial","BH0155",162,{"v":1e-43,"d":"1.00E-43"},"COG0563","pfam00406","ADK","Adenylate kinase.","GO:0001889|liver development;GO:0002082|regulation of oxidative phosphorylation;GO:0006165|nucleoside diphosphate phosphorylation;GO:0006172|ADP biosynthetic process;GO:0007420|brain development;GO:0009142|nucleoside triphosphate biosynthetic process;GO:0009410|response to xenobiotic stimulus;GO:0046033|AMP metabolic process;GO:0046034|ATP metabolic process;GO:0046039|GTP metabolic process;GO:0046940|nucleoside monophosphate phosphorylation;GO:0071456|cellular response to hypoxia;GO:2001169|regulation of ATP biosynthetic process;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005759|mitochondrial matrix;","GO:0003674|molecular_function;GO:0004017|adenylate kinase activity;GO:0004550|nucleoside diphosphate kinase activity;GO:0005524|ATP binding;GO:0005525|GTP binding;GO:0046899|nucleoside triphosphate adenylate kinase activity;","K00939","adk, AK; adenylate kinase [EC:2.7.4.3]"]
["ENSRNOG00000009329",121,10.04622592,553,35.57473232,0.282397794,-1.824199277,{"v":2.95589e-47,"d":"2.96E-47"},{"v":2.33049e-46,"d":"2.33E-46"},"down","yes","Nr1d1","protein_coding","chr10:83728318-83735705:-","gi|625254396|ref|XP_007618538.1|",2592,0,"PREDICTED: nuclear receptor subfamily 1 group D member 1 isoform X2 [Cricetulus griseus]","gi|583828531|ref|NM_145434.4|",1915,0,"Mus musculus nuclear receptor subfamily 1, group D, member 1 (Nr1d1), mRNA","Q63503",962,0,"Nuclear receptor subfamily 1 group D member 1",".",".",".",".","pfam00105","zf-C4","Zinc finger, C4 type (two domains). In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001678|cellular glucose homeostasis;GO:0005978|glycogen biosynthetic process;GO:0006355|regulation of transcription, DNA-templated;GO:0007623|circadian rhythm;GO:0009648|photoperiodism;GO:0009755|hormone-mediated signaling pathway;GO:0010498|proteasomal protein catabolic process;GO:0019216|regulation of lipid metabolic process;GO:0030154|cell differentiation;GO:0030522|intracellular receptor signaling pathway;GO:0031648|protein destabilization;GO:0032922|circadian regulation of gene expression;GO:0034144|negative regulation of toll-like receptor 4 signaling pathway;GO:0042632|cholesterol homeostasis;GO:0042749|regulation of circadian sleep/wake cycle;GO:0042752|regulation of circadian rhythm;GO:0042753|positive regulation of circadian rhythm;GO:0043124|negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0044321|response to leptin;GO:0045598|regulation of fat cell differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050728|negative regulation of inflammatory response;GO:0060086|circadian temperature homeostasis;GO:0061178|regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0061469|regulation of type B pancreatic cell proliferation;GO:0061889|negative regulation of astrocyte activation;GO:0070859|positive regulation of bile acid biosynthetic process;GO:0071222|cellular response to lipopolysaccharide;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0120163|negative regulation of cold-induced thermogenesis;GO:0150079|negative regulation of neuroinflammatory response;GO:1903979|negative regulation of microglial cell activation;GO:2000489|regulation of hepatic stellate cell activation;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0016604|nuclear body;GO:0030425|dendrite;GO:0043025|neuronal cell body;GO:0043197|dendritic spine;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001222|transcription corepressor binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0004879|nuclear receptor activity;GO:0005515|protein binding;GO:0008270|zinc ion binding;GO:0020037|heme binding;GO:0043565|sequence-specific DNA binding;GO:0070888|E-box binding;GO:1990837|sequence-specific double-stranded DNA binding;","K03728","NR1D1; nuclear receptor subfamily 1 group D member 1"]
["ENSRNOG00000026128",333,27.64787795,999,64.26610775,0.430209311,-1.216889345,{"v":6.66186e-47,"d":"6.66E-47"},{"v":5.24589e-46,"d":"5.25E-46"},"down","yes","Cpne8","protein_coding","chr7:121615294-121790377:-","gi|149017588|gb|EDL76592.1|",2258,0,"rCG59255, isoform CRA_b [Rattus norvegicus]","gi|755552026|ref|XM_006521286.2|",2941,0,"PREDICTED: Mus musculus copine VIII (Cpne8), transcript variant X2, mRNA",".",".",".",".","YOR086c",53.5,6e-06,"COG5038","pfam07002","Copine","Copine. This family represents a conserved region approximately 180 residues long within eukaryotic copines. Copines are Ca(2+)-dependent phospholipid-binding proteins that are thought to be involved in membrane-trafficking, and may also be involved in cell division and growth.","GO:0071277|cellular response to calcium ion;","GO:0005886|plasma membrane;","GO:0005544|calcium-dependent phospholipid binding;","K24523","CPNE5_8_9; copine 5/8/9"]
["ENSRNOG00000063040",156,12.95215904,630,40.52817606,0.31958406,-1.645732643,{"v":1.22829e-46,"d":"1.23E-46"},{"v":9.60124e-46,"d":"9.60E-46"},"down","yes","ENSRNOG00000063040","protein_coding","chr9:114137793-114149279:+","gi|564349900|ref|XP_006237777.1|",738,{"v":2e-142,"d":"2.00E-142"},"PREDICTED: zinc finger protein 431-like isoform X3 [Rattus norvegicus]","gi|672051756|ref|XR_353790.2|",713,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102550336 (LOC102550336), ncRNA","E9QAG8",303,{"v":1E-108,"d":"1.00E-108"},"Zinc finger protein 431",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000011100",326,27.06669133,983,63.23682074,0.428021065,-1.224246296,{"v":1.3254e-46,"d":"1.33E-46"},{"v":1.0335E-45,"d":"1.03E-45"},"down","yes","AABR07040947.1","protein_coding","chr13:65941100-65942227:-","gi|585645604|ref|XP_006882199.1|",1080,{"v":3e-142,"d":"3.00E-142"},"PREDICTED: heterogeneous nuclear ribonucleoprotein A3-like [Elephantulus edwardii]","gi|831228654|ref|XM_012806181.1|",843,0,"PREDICTED: Otolemur garnettii heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3), mRNA","P51991",384,{"v":5e-130,"d":"5.00E-130"},"Heterogeneous nuclear ribonucleoprotein A3",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.",".",".",".",".","."]
["ENSRNOG00000042826",150,12.45399908,614,39.49888905,0.315299984,-1.665202999,{"v":3.08412e-46,"d":"3.08E-46"},{"v":2.38743e-45,"d":"2.39E-45"},"down","yes","Zfp52","protein_coding","chr1:61335270-61363102:+","gi|62079051|ref|NP_001014180.1|",3913,0,"zinc finger protein 52 [Rattus norvegicus]","gi|62079050|ref|NM_001014158.1|",2385,0,"Rattus norvegicus zinc finger protein 52 (Zfp52), mRNA","Q8TAQ5",621,0,"Zinc finger protein 420",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;",".","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0046872|metal ion binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSRNOG00000019931",142,11.78978579,595,38.27661072,0.308015406,-1.698925583,{"v":4.20147e-46,"d":"4.20E-46"},{"v":3.23281e-45,"d":"3.23E-45"},"down","yes","Map3k21","protein_coding","chr19:53880238-53913576:+","gi|672085451|ref|XP_008770896.1|",4117,0,"PREDICTED: LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase MLK4 isoform X2 [Rattus norvegicus]","gi|672085450|ref|XM_008772674.1|",5701,0,"PREDICTED: Rattus norvegicus similar to Mixed lineage kinase 4 (RGD1306091), transcript variant X2, mRNA","Q8VDG6",1424,0,"Mitogen-activated protein kinase kinase kinase 21",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0000165|MAPK cascade;GO:0006468|protein phosphorylation;",".","GO:0004672|protein kinase activity;GO:0004706|JUN kinase kinase kinase activity;GO:0004709|MAP kinase kinase kinase activity;GO:0005524|ATP binding;","K17534","MLK4, KIAA1804; mitogen-activated protein kinase kinase kinase MLK4 [EC:2.7.11.25]"]
["ENSRNOG00000014004",287,23.82865157,897,57.70440305,0.412943386,-1.275984092,{"v":2.01315e-45,"d":"2.01E-45"},{"v":1.53059E-44,"d":"1.53E-44"},"down","yes","Ncoa7","protein_coding","chr1:26856530-27015871:+","gi|564324906|ref|XP_006227820.1|",4682,0,"PREDICTED: nuclear receptor coactivator 7 isoform X4 [Rattus norvegicus]","gi|672034067|ref|XM_006227758.2|",3866,0,"PREDICTED: Rattus norvegicus nuclear receptor coactivator 7 (Ncoa7), transcript variant X4, mRNA","Q6DFV7",1581,0,"Nuclear receptor coactivator 7","YPL196w",71.6,{"v":1e-12,"d":"1.00E-12"},"COG5142","pfam07534","TLD","TLD. This domain is predicted to be an enzyme and is often found associated with pfam01476. It's structure consists of a beta-sandwich surrounded by two helices and two one-turn helices.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0006979|response to oxidative stress;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:1900408|negative regulation of cellular response to oxidative stress;GO:1902083|negative regulation of peptidyl-cysteine S-nitrosylation;GO:1903204|negative regulation of oxidative stress-induced neuron death;","GO:0005634|nucleus;","GO:0016922|nuclear receptor binding;GO:0030374|nuclear receptor transcription coactivator activity;","K25442","NCOA7; nuclear receptor coactivator 7"]
["ENSRNOG00000010617",367,30.47078441,1050,67.54696009,0.451105192,-1.148464204,{"v":4.9019e-45,"d":"4.90E-45"},{"v":3.68744e-44,"d":"3.69E-44"},"down","yes","Scube1","protein_coding","chr7:114759010-114880940:-","gi|564361208|ref|XP_006242154.1|",4750,0,"PREDICTED: signal peptide, CUB and EGF-like domain-containing protein 1 isoform X1 [Rattus norvegicus]","gi|672060007|ref|XM_006242092.2|",2817,0,"PREDICTED: Rattus norvegicus signal peptide, CUB domain, EGF-like 1 (Scube1), transcript variant X1, mRNA","Q6NZL8",1772,0,"Signal peptide, CUB and EGF-like domain-containing protein 1",".",".",".",".","pfam00431","CUB","CUB domain.","GO:0007165|signal transduction;GO:0045880|positive regulation of smoothened signaling pathway;","GO:0005615|extracellular space;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0019897|extrinsic component of plasma membrane;","GO:0005509|calcium ion binding;GO:0042802|identical protein binding;","K24468","SCUBE1_3; signal peptide, CUB and EGF-like domain-containing protein 1/3"]
["ENSRNOG00000065022",177,14.69571891,665,42.77974139,0.343520518,-1.541531824,{"v":7.51973e-45,"d":"7.52E-45"},{"v":5.65005e-44,"d":"5.65E-44"},"down","yes","RGD1560394","protein_coding","chr14:76768146-76773575:-","gi|564384243|ref|XP_006251255.1|",472,{"v":1E-50,"d":"1.00E-50"},"PREDICTED: neuropeptide-like protein C4orf48 homolog isoform X1 [Rattus norvegicus]","gi|672076586|ref|XM_006251193.2|",509,0,"PREDICTED: Rattus norvegicus RGD1560394 (RGD1560394), transcript variant X1, mRNA","Q3UR78",126,{"v":6e-32,"d":"6.00E-32"},"Neuropeptide-like protein C4orf48 homolog",".",".",".",".","pfam15161","Neuropep_like","Neuropeptide-like. This family contains putative neuropeptides.",".",".",".",".","."]
["ENSRNOG00000029401",335,27.81393128,970,62.40052504,0.445732328,-1.165750496,{"v":1.05082E-42,"d":"1.05E-42"},{"v":7.5836E-42,"d":"7.58E-42"},"down","yes","Actg2","protein_coding","chr4:116021832-116046465:-","gi|528767717|gb|EPY87376.1|",2078,0,"hypothetical protein CB1_000252031 [Camelus ferus]","gi|672050141|ref|XM_006236728.2|",1343,0,"PREDICTED: Rattus norvegicus actin, gamma 2, smooth muscle, enteric (Actg2), transcript variant X1, mRNA","P63269",786,0,"Actin, gamma-enteric smooth muscle","SPBC32H8.12c",711,0,"COG5277","pfam00022","Actin","Actin.","GO:0008150|biological_process;GO:0010628|positive regulation of gene expression;GO:0014829|vascular smooth muscle contraction;GO:0090131|mesenchyme migration;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005869|dynactin complex;GO:0030027|lamellipodium;GO:0030175|filopodium;GO:0032982|myosin filament;GO:0044297|cell body;GO:0071944|cell periphery;","GO:0003674|molecular_function;GO:0005524|ATP binding;","K12315","ACTG2; actin, gamma-enteric smooth muscle"]
["ENSRNOG00000068024",53,4.400413008,352,22.64431424,0.194327501,-2.363438008,{"v":4.39104e-42,"d":"4.39E-42"},{"v":3.12659e-41,"d":"3.13E-41"},"down","yes","B3gnt8","protein_coding","chr1:81135499-81142263:+","gi|157819259|ref|NP_001100962.1|",1890,0,"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 [Rattus norvegicus]","gi|672035067|ref|XM_006228434.2|",2663,0,"PREDICTED: Rattus norvegicus UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 (B3gnt8), transcript variant X3, mRNA","Q8R3I9",717,0,"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8","VNG1926G",67.4,{"v":1E-10,"d":"1.00E-10"},"COG1071","pfam01762","Galactosyl_T","Galactosyltransferase. This family includes the galactosyltransferases UDP-galactose:2-acetamido-2-deoxy-D-glucose3beta-galactosyltransferase and UDP-Gal:beta-GlcNAc beta 1,3-galactosyltranferase. Specific galactosyltransferases transfer galactose to GlcNAc terminal chains in the synthesis of the lacto-series oligosaccharides types 1 and 2.",".",".",".",".","."]
["ENSRNOG00000014692",113,9.382012639,500,32.16521909,0.291681913,-1.777532166,{"v":1.87288E-41,"d":"1.87E-41"},{"v":1.31887e-40,"d":"1.32E-40"},"down","yes","Mogat1","protein_coding","chr9:79956649-79988513:+","gi|229577408|ref|NP_080989.2|",1370,0,"2-acylglycerol O-acyltransferase 1 [Mus musculus]","gi|229577407|ref|NM_026713.3|",590,0,"Mus musculus monoacylglycerol O-acyltransferase 1 (Mogat1), mRNA","Q91ZV4",532,0,"2-acylglycerol O-acyltransferase 1",".",".",".",".","pfam03982","DAGAT","Diacylglycerol acyltransferase. The terminal step of triacylglycerol (TAG) formation is catalysed by the enzyme diacylglycerol acyltransferase (DAGAT).","GO:0006629|lipid metabolic process;GO:0006651|diacylglycerol biosynthetic process;GO:0019432|triglyceride biosynthetic process;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016020|membrane;","GO:0003846|2-acylglycerol O-acyltransferase activity;GO:0004144|diacylglycerol O-acyltransferase activity;GO:0008374|O-acyltransferase activity;","K14458","MOGAT1, MGAT1; 2-acylglycerol O-acyltransferase 1 [EC:2.3.1.22]"]
["ENSRNOG00000014320",180,14.94479889,649,41.75045438,0.357955359,-1.482148415,{"v":1.91831e-41,"d":"1.92E-41"},{"v":1.34938E-40,"d":"1.35E-40"},"down","yes","Inhba","protein_coding","chr17:49095920-49108982:-","gi|880891048|ref|XP_012970113.1|",2087,0,"PREDICTED: inhibin beta A chain [Mesocricetus auratus]","gi|672081983|ref|XM_008771716.1|",1544,0,"PREDICTED: Rattus norvegicus inhibin beta-A (Inhba), transcript variant X6, mRNA","P18331",806,0,"Inhibin beta A chain",".",".",".",".","pfam00019","TGF_beta","Transforming growth factor beta like domain.","GO:0000082|G1/S transition of mitotic cell cycle;GO:0001541|ovarian follicle development;GO:0001707|mesoderm formation;GO:0001942|hair follicle development;GO:0002244|hematopoietic progenitor cell differentiation;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008285|negative regulation of cell proliferation;GO:0008584|male gonad development;GO:0009410|response to xenobiotic stimulus;GO:0010628|positive regulation of gene expression;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0021773|striatal medium spiny neuron differentiation;GO:0030308|negative regulation of cell growth;GO:0032270|positive regulation of cellular protein metabolic process;GO:0032924|activin receptor signaling pathway;GO:0035987|endodermal cell differentiation;GO:0042476|odontogenesis;GO:0042541|hemoglobin biosynthetic process;GO:0042701|progesterone secretion;GO:0045648|positive regulation of erythrocyte differentiation;GO:0045786|negative regulation of cell cycle;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046880|regulation of follicle-stimulating hormone secretion;GO:0048333|mesodermal cell differentiation;GO:0051726|regulation of cell cycle;GO:0051799|negative regulation of hair follicle development;GO:0060021|roof of mouth development;GO:0060279|positive regulation of ovulation;GO:0060395|SMAD protein signal transduction;GO:0061029|eyelid development in camera-type eye;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0071397|cellular response to cholesterol;GO:0097154|GABAergic neuron differentiation;GO:0097191|extrinsic apoptotic signaling pathway;GO:2001241|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0043509|activin A complex;GO:0043512|inhibin A complex;GO:0048471|perinuclear region of cytoplasm;","GO:0005102|signaling receptor binding;GO:0005125|cytokine activity;GO:0005179|hormone activity;GO:0008083|growth factor activity;GO:0017046|peptide hormone binding;GO:0034711|inhibin binding;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;GO:0070699|type II activin receptor binding;","K04667","INHBA; inhibin beta A chain"]
["ENSRNOG00000000552",243,20.17547851,775,49.85608959,0.404674307,-1.30516684,{"v":7.86152e-41,"d":"7.86E-41"},{"v":5.46979e-40,"d":"5.47E-40"},"down","yes","Col13a1","protein_coding","chr20:29783965-29924032:-","gi|157821425|ref|NP_001102642.1|",1062,{"v":2e-126,"d":"2.00E-126"},"collagen alpha-1(XIII) chain [Rattus norvegicus]","gi|157821424|ref|NM_001109172.1|",3146,0,"Rattus norvegicus collagen, type XIII, alpha 1 (Col13a1), mRNA","Q9R1N9",390,{"v":4e-119,"d":"4.00E-119"},"Collagen alpha-1(XIII) chain",".",".",".",".","pfam01391","Collagen","Collagen triple helix repeat (20 copies). Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxyproline. Collagens are post translationally modified by proline hydroxylase to form the hydroxyproline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure.","GO:0001501|skeletal system development;GO:0001763|morphogenesis of a branching structure;GO:0001958|endochondral ossification;GO:0007160|cell-matrix adhesion;GO:0030198|extracellular matrix organization;GO:0030199|collagen fibril organization;GO:0030903|notochord development;GO:0098609|cell-cell adhesion;","GO:0005581|collagen trimer;GO:0005615|extracellular space;GO:0005911|cell-cell junction;GO:0031012|extracellular matrix;","GO:0005201|extracellular matrix structural constituent;GO:0008201|heparin binding;","K16617","COL13A; collagen type XIII alpha"]
["ENSRNOG00000029220",383,31.79921098,1045,67.2253079,0.473024401,-1.080013489,{"v":9.20881e-41,"d":"9.21E-41"},{"v":6.39328e-40,"d":"6.39E-40"},"down","yes","Zmym5","protein_coding","chr15:30923241-30941240:-","gi|392333305|ref|XP_002725142.2|",3068,0,"PREDICTED: zinc finger MYM-type protein 5 [Rattus norvegicus]","gi|672028533|ref|XM_006221946.2|",2240,0,"PREDICTED: Rattus norvegicus similar to Zinc finger protein 198 (Fused in myeloproliferative disorders protein) (Rearranged in atypical myeloproliferative disorder protein) (RGD1306353), transcript variant X2, mRNA","Q3U2E2",1013,0,"Zinc finger MYM-type protein 5",".",".",".",".","pfam06467","zf-FCS","MYM-type Zinc finger with FCS sequence motif. MYM-type zinc fingers were identified in MYM family proteins. Human protein ZMYM3 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. ZMYM2 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.","GO:0000122|negative regulation of transcription by RNA polymerase II;",".","GO:0008270|zinc ion binding;","K24676","ZMYM5; zinc finger MYM-type protein 5"]
["ENSRNOG00000000010",119,9.880172602,503,32.35821041,0.305337424,-1.71152367,{"v":1.22849E-39,"d":"1.23E-39"},{"v":8.3476e-39,"d":"8.35E-39"},"down","yes","Cbln1","protein_coding","chr19:19608716-19612572:+","gi|507654072|ref|XP_004704743.1|",942,{"v":2E-118,"d":"2.00E-118"},"PREDICTED: cerebellin-1 [Echinops telfairi]","gi|157820084|ref|NM_001109127.1|",2444,0,"Rattus norvegicus cerebellin 1 precursor (Cbln1), mRNA","Q9R171",367,{"v":9E-120,"d":"9.00E-120"},"Cerebellin-1",".",".",".",".","pfam00386","C1q","C1q domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.","GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0009306|protein secretion;GO:0021707|cerebellar granule cell differentiation;GO:0050808|synapse organization;GO:0051965|positive regulation of synapse assembly;GO:0090394|negative regulation of excitatory postsynaptic potential;GO:0099151|regulation of postsynaptic density assembly;GO:0099558|maintenance of synapse structure;GO:1900454|positive regulation of long-term synaptic depression;GO:1905606|regulation of presynapse assembly;GO:1905703|negative regulation of inhibitory synapse assembly;","GO:0005576|extracellular region;GO:0043083|synaptic cleft;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0098688|parallel fiber to Purkinje cell synapse;GO:0098978|glutamatergic synapse;","GO:0042802|identical protein binding;","K24235","CBLN; cerebellin"]
["ENSRNOG00000002802",58,4.81554631,353,22.70864468,0.212057848,-2.237470222,{"v":1.2816e-39,"d":"1.28E-39"},{"v":8.69922e-39,"d":"8.70E-39"},"down","yes","Cxcl1","protein_coding","chr14:17193365-17195215:-","gi|13540652|ref|NP_110472.1|",442,{"v":5E-51,"d":"5.00E-51"},"growth-regulated alpha protein precursor [Rattus norvegicus]","gi|13540651|ref|NM_030845.1|",909,0,"Rattus norvegicus chemokine (C-X-C motif) ligand 1 (Cxcl1), mRNA","P14095",174,{"v":2E-52,"d":"2.00E-52"},"Growth-regulated alpha protein",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0001975|response to amphetamine;GO:0002526|acute inflammatory response;GO:0006952|defense response;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007165|signal transduction;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0009408|response to heat;GO:0010332|response to gamma radiation;GO:0010765|positive regulation of sodium ion transport;GO:0030593|neutrophil chemotaxis;GO:0031640|killing of cells of other organism;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0032930|positive regulation of superoxide anion generation;GO:0043268|positive regulation of potassium ion transport;GO:0051384|response to glucocorticoid;GO:0060326|cell chemotaxis;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098|chemokine-mediated signaling pathway;GO:0070965|positive regulation of neutrophil mediated killing of fungus;GO:0071222|cellular response to lipopolysaccharide;GO:1902035|positive regulation of hematopoietic stem cell proliferation;","GO:0005615|extracellular space;","GO:0008009|chemokine activity;GO:0008083|growth factor activity;GO:0045236|CXCR chemokine receptor binding;","K05505","CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3"]
["ENSRNOG00000022309",30,2.490799816,272,17.49787919,0.142348669,-2.812499089,{"v":1.59412e-39,"d":"1.59E-39"},{"v":1.07862E-38,"d":"1.08E-38"},"down","yes","Frem1","protein_coding","chr5:97322538-97469543:-","gi|300795821|ref|NP_001178686.1|",11472,0,"FRAS1-related extracellular matrix protein 1 precursor [Rattus norvegicus]","gi|300795820|ref|NM_001191757.1|",6630,0,"Rattus norvegicus Fras1 related extracellular matrix 1 (Frem1), mRNA","Q684R7",3979,0,"FRAS1-related extracellular matrix protein 1",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0007154|cell communication;GO:0007160|cell-matrix adhesion;GO:0008150|biological_process;GO:0097094|craniofacial suture morphogenesis;","GO:0005575|cellular_component;GO:0005604|basement membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;","K23380","FREM1_2; FRAS1-related extracelluar matrix protein 1/2"]
["ENSRNOG00000023257",131,10.87649253,527,33.90214092,0.320820226,-1.640162994,{"v":4.07507e-39,"d":"4.08E-39"},{"v":2.74278e-38,"d":"2.74E-38"},"down","yes","Adamts9","protein_coding","chr4:125291490-125462929:-","gi|564347897|ref|XP_006236978.1|",8264,0,"PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X3 [Rattus norvegicus]","gi|672050431|ref|XM_008763126.1|",2154,0,"PREDICTED: Rattus norvegicus ADAM metallopeptidase with thrombospondin type 1 motif, 9 (Adamts9), transcript variant X2, mRNA","Q9P2N4",2703,0,"A disintegrin and metalloproteinase with thrombospondin motifs 9",".",".",".",".","pfam08685","GON","GON domain. The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) family of proteins. It contains several conserved cysteine residues.","GO:0003179|heart valve morphogenesis;GO:0003229|ventricular cardiac muscle tissue development;GO:0006508|proteolysis;GO:0007229|integrin-mediated signaling pathway;GO:0009617|response to bacterium;GO:0010596|negative regulation of endothelial cell migration;GO:0030198|extracellular matrix organization;GO:0035909|aorta morphogenesis;GO:0045636|positive regulation of melanocyte differentiation;GO:0048070|regulation of developmental pigmentation;GO:0090673|endothelial cell-matrix adhesion;GO:1903671|negative regulation of sprouting angiogenesis;","GO:0005615|extracellular space;GO:0005783|endoplasmic reticulum;GO:0009986|cell surface;GO:0031012|extracellular matrix;GO:0043231|intracellular membrane-bounded organelle;","GO:0004175|endopeptidase activity;GO:0004222|metalloendopeptidase activity;GO:0008237|metallopeptidase activity;GO:0008270|zinc ion binding;","K08624","ADAMTS9; a disintegrin and metalloproteinase with thrombospondin motifs 9 [EC:3.4.24.-]"]
["ENSRNOG00000003973",324,26.90063801,919,59.11967269,0.455020077,-1.135997892,{"v":5.61561e-39,"d":"5.62E-39"},{"v":3.76777e-38,"d":"3.77E-38"},"down","yes","Cyb5r1","protein_coding","chr13:45849091-45855458:+","gi|149058572|gb|EDM09729.1|",1189,{"v":3E-157,"d":"3.00E-157"},"cytochrome b5 reductase 1 [Rattus norvegicus]","gi|672074092|ref|XR_358907.2|",1638,0,"PREDICTED: Rattus norvegicus cytochrome b5 reductase 1 (Cyb5r1), transcript variant X1, misc_RNA","Q5EB81",460,{"v":6E-158,"d":"6.00E-158"},"NADH-cytochrome b5 reductase 1","SPCC970.03",159,{"v":3E-43,"d":"3.00E-43"},"COG0543","pfam00970","FAD_binding_6","Oxidoreductase FAD-binding domain.","GO:0016126|sterol biosynthetic process;","GO:0016021|integral component of membrane;","GO:0004128|cytochrome-b5 reductase activity, acting on NAD(P)H;GO:0071949|FAD binding;","K00326","E1.6.2.2; cytochrome-b5 reductase [EC:1.6.2.2]"]
["ENSRNOG00000023548",335,27.81393128,937,60.27762058,0.461430478,-1.115814796,{"v":1.25927e-38,"d":"1.26E-38"},{"v":8.37865e-38,"d":"8.38E-38"},"down","yes","Sned1","protein_coding","chr9:93774119-93830694:+","gi|564369824|ref|XP_006245588.1|",7023,0,"PREDICTED: sushi, nidogen and EGF-like domain-containing protein 1 isoform X3 [Rattus norvegicus]","gi|672066159|ref|XM_006245526.2|",5615,0,"PREDICTED: Rattus norvegicus sushi, nidogen and EGF-like domains 1 (Sned1), transcript variant X4, mRNA","Q5ZQU0",2708,0,"Sushi, nidogen and EGF-like domain-containing protein 1",".",".",".",".","pfam06119","NIDO","Nidogen-like. This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function.","GO:0007160|cell-matrix adhesion;","GO:0005576|extracellular region;","GO:0005112|Notch binding;GO:0005509|calcium ion binding;","K24470","SNED1, IRE-BP1; insulin-responsive sequence DNA-binding protein 1"]
["ENSRNOG00000057153",349,28.97630452,963,61.95021197,0.467735357,-1.096235605,{"v":1.40008E-38,"d":"1.40E-38"},{"v":9.28658e-38,"d":"9.29E-38"},"down","yes","Pla1a","protein_coding","chr11:62320493-62357779:+","gi|20302059|ref|NP_620237.1|",2343,0,"phospholipase A1 member A precursor [Rattus norvegicus]","gi|51261143|gb|BC078727.1|",1717,0,"Rattus norvegicus phospholipase A1 member A, mRNA (cDNA clone MGC:93173 IMAGE:7124402), complete cds","P97535",907,0,"Phospholipase A1 member A",".",".",".",".","pfam00151","Lipase","Lipase.","GO:0016042|lipid catabolic process;","GO:0002080|acrosomal membrane;GO:0005615|extracellular space;","GO:0004806|triglyceride lipase activity;GO:0008970|phospholipase A1 activity;GO:0016298|lipase activity;","K13618","PLA1A; phosphatidylserine sn-1 acylhydrolase [EC:3.1.1.111]"]
["ENSRNOG00000067047",65,5.396732934,366,23.54494038,0.229209879,-2.125258869,{"v":1.40729E-38,"d":"1.41E-38"},{"v":9.32471e-38,"d":"9.32E-38"},"down","yes","ENSRNOG00000067047","lncRNA","chrX:645177-647888:-","gi|149045626|gb|EDL98626.1|",357,{"v":1E-35,"d":"1.00E-35"},"putative retrovirus-related gag protein, partial [Rattus norvegicus]","gi|46240867|gb|AC107531.8|",1223,0,"Rattus norvegicus 1 BAC CH230-158N3 (Children's Hospital Oakland Research Institute) complete sequence","P31790",71.2,{"v":3e-12,"d":"3.00E-12"},"Intracisternal A-particle Gag-related polyprotein",".",".",".",".","pfam02337","Gag_p10","Retroviral GAG p10 protein. This family consists of various retroviral GAG (core) polyproteins and encompasses the p10 region producing the p10 protein upon proteolytic cleavage of GAG by retroviral protease. The p10 or matrix protein (MA) is associated with the virus envelope glycoproteins in most mammalian retroviruses and may be involved in virus particle assembly, transport and budding. Some of the GAG polyproteins have alternate cleavage sites leading to the production of alternative and longer cleavage products (e.g. p19) the alignment of this family only covers the approximately N-terminal (GAG) 100 amino acid region of homology to p10.",".",".",".",".","."]
["ENSRNOG00000004050",363,30.13867777,987,63.49414249,0.474668632,-1.07500738,{"v":2.55943e-38,"d":"2.56E-38"},{"v":1.68541e-37,"d":"1.69E-37"},"down","yes","Snrk","protein_coding","chr8:121793302-121832323:+","gi|20301962|ref|NP_620188.1|",3279,0,"SNF-related serine/threonine-protein kinase [Rattus norvegicus]","gi|20301961|ref|NM_138833.1|",2985,0,"Rattus norvegicus SNF related kinase (Snrk), mRNA","Q63553",1267,0,"SNF-related serine/threonine-protein kinase",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006468|protein phosphorylation;GO:0035556|intracellular signal transduction;GO:0043523|regulation of neuron apoptotic process;","GO:0005634|nucleus;","GO:0000287|magnesium ion binding;GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;","K08802","SNRK; SNF related kinase [EC:2.7.11.1]"]
["ENSRNOG00000028390",120,9.963199263,489,31.45758427,0.316718511,-1.658726903,{"v":5.54888e-37,"d":"5.55E-37"},{"v":3.55869e-36,"d":"3.56E-36"},"down","yes","Hhipl1","protein_coding","chr6:127220014-127242564:+","gi|293360094|ref|XP_343108.4|",3608,0,"PREDICTED: HHIP-like protein 1 [Rattus norvegicus]","gi|672057077|ref|XM_343107.7|",3643,0,"PREDICTED: Rattus norvegicus HHIP-like 1 (Hhipl1), mRNA","Q14DK5",1319,0,"HHIP-like protein 1","slr1608",87.4,{"v":4e-17,"d":"4.00E-17"},"COG2133","pfam00530","SRCR","Scavenger receptor cysteine-rich domain. These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.","GO:0006897|endocytosis;","GO:0016020|membrane;","GO:0003824|catalytic activity;GO:0005044|scavenger receptor activity;","K25557","HHIPL; HHIP-like protein"]
["ENSRNOG00000048118",271,22.500225,800,51.46435055,0.437200213,-1.193633992,{"v":8.08186e-37,"d":"8.08E-37"},{"v":5.14703e-36,"d":"5.15E-36"},"down","yes","Ankra2","protein_coding","chr2:29612925-29623730:+","gi|46485431|ref|NP_997478.1|",1683,0,"ankyrin repeat family A protein 2 [Rattus norvegicus]","gi|564299675|ref|XM_003753510.2|",1807,0,"PREDICTED: Rattus norvegicus ankyrin repeat family A protein 2-like (LOC100910438), transcript variant X1, mRNA","Q2KI79",639,0,"Ankyrin repeat family A protein 2","all2748",89.4,{"v":3e-18,"d":"3.00E-18"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0010468|regulation of gene expression;GO:0043254|regulation of protein complex assembly;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016020|membrane;GO:0032991|protein-containing complex;","GO:0019901|protein kinase binding;GO:0031625|ubiquitin protein ligase binding;GO:0042826|histone deacetylase binding;GO:0050750|low-density lipoprotein particle receptor binding;","K21486","ANKRA2; ankyrin repeat family A protein 2"]
["ENSRNOG00000017523",389,32.29737094,1017,65.42405563,0.493662012,-1.018404463,{"v":3.10411e-36,"d":"3.10E-36"},{"v":1.95162E-35,"d":"1.95E-35"},"down","yes","H6pd","protein_coding","chr5:160438697-160470171:-","gi|157821675|ref|NP_001100168.1|",4150,0,"GDH/6PGL endoplasmic bifunctional protein precursor [Rattus norvegicus]","gi|157821674|ref|NM_001106698.1|",4449,0,"Rattus norvegicus hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) (H6pd), mRNA","Q8CFX1",1524,0,"GDH/6PGL endoplasmic bifunctional protein","YNL241c",195,{"v":1E-51,"d":"1.00E-51"},"COG0364","pfam01182","Glucosamine_iso","Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase.","GO:0005975|carbohydrate metabolic process;GO:0006006|glucose metabolic process;GO:0006098|pentose-phosphate shunt;GO:0006739|NADP metabolic process;GO:0009051|pentose-phosphate shunt, oxidative branch;GO:0097305|response to alcohol;GO:2000064|regulation of cortisol biosynthetic process;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005783|endoplasmic reticulum;GO:0005788|endoplasmic reticulum lumen;GO:0016529|sarcoplasmic reticulum;GO:0043231|intracellular membrane-bounded organelle;","GO:0004345|glucose-6-phosphate dehydrogenase activity;GO:0017057|6-phosphogluconolactonase activity;GO:0030246|carbohydrate binding;GO:0050661|NADP binding;","K13937","H6PD; hexose-6-phosphate dehydrogenase [EC:1.1.1.47 3.1.1.31]"]
["ENSRNOG00000001414",121,10.04622592,486,31.26459296,0.321329177,-1.63787611,{"v":3.87616e-36,"d":"3.88E-36"},{"v":2.43224e-35,"d":"2.43E-35"},"down","yes","Serpine1","protein_coding","chr12:19601272-19611657:+","gi|6981332|ref|NP_036752.1|",2140,0,"plasminogen activator inhibitor 1 precursor [Rattus norvegicus]","gi|6981331|ref|NM_012620.1|",2982,0,"Rattus norvegicus serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (Serpine1), mRNA","P20961",828,0,"Plasminogen activator inhibitor 1","all0778",168,{"v":4e-44,"d":"4.00E-44"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0000302|response to reactive oxygen species;GO:0001525|angiogenesis;GO:0001890|placenta development;GO:0008585|female gonad development;GO:0010469|regulation of signaling receptor activity;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010757|negative regulation of plasminogen activation;GO:0010951|negative regulation of endopeptidase activity;GO:0014912|negative regulation of smooth muscle cell migration;GO:0030194|positive regulation of blood coagulation;GO:0030336|negative regulation of cell migration;GO:0031667|response to nutrient levels;GO:0032496|response to lipopolysaccharide;GO:0032757|positive regulation of interleukin-8 production;GO:0032869|cellular response to insulin stimulus;GO:0032967|positive regulation of collagen biosynthetic process;GO:0033629|negative regulation of cell adhesion mediated by integrin;GO:0034097|response to cytokine;GO:0034616|response to laminar fluid shear stress;GO:0035491|positive regulation of leukotriene production involved in inflammatory response;GO:0035865|cellular response to potassium ion;GO:0036120|cellular response to platelet-derived growth factor stimulus;GO:0042127|regulation of cell proliferation;GO:0042246|tissue regeneration;GO:0042593|glucose homeostasis;GO:0042594|response to starvation;GO:0043627|response to estrogen;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0045576|mast cell activation;GO:0045765|regulation of angiogenesis;GO:0045766|positive regulation of angiogenesis;GO:0046697|decidualization;GO:0048146|positive regulation of fibroblast proliferation;GO:0048260|positive regulation of receptor-mediated endocytosis;GO:0050729|positive regulation of inflammatory response;GO:0050820|positive regulation of coagulation;GO:0050829|defense response to Gram-negative bacterium;GO:0051549|positive regulation of keratinocyte migration;GO:0051918|negative regulation of fibrinolysis;GO:0055093|response to hyperoxia;GO:0061044|negative regulation of vascular wound healing;GO:0070301|cellular response to hydrogen peroxide;GO:0070849|response to epidermal growth factor;GO:0071222|cellular response to lipopolysaccharide;GO:0071248|cellular response to metal ion;GO:0071258|cellular response to gravity;GO:0071260|cellular response to mechanical stimulus;GO:0071316|cellular response to nicotine;GO:0071318|cellular response to ATP;GO:0071320|cellular response to cAMP;GO:0071321|cellular response to cGMP;GO:0071333|cellular response to glucose stimulus;GO:0071347|cellular response to interleukin-1;GO:0071363|cellular response to growth factor stimulus;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0071377|cellular response to glucagon stimulus;GO:0071404|cellular response to low-density lipoprotein particle stimulus;GO:0071407|cellular response to organic cyclic compound;GO:0071409|cellular response to cycloheximide;GO:0071456|cellular response to hypoxia;GO:0071466|cellular response to xenobiotic stimulus;GO:0071549|cellular response to dexamethasone stimulus;GO:0071559|response to transforming growth factor beta;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0090026|positive regulation of monocyte chemotaxis;GO:0090280|positive regulation of calcium ion import;GO:0090399|replicative senescence;GO:0097187|dentinogenesis;GO:1901331|positive regulation of odontoblast differentiation;GO:1902042|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1904045|cellular response to aldosterone;GO:1904385|cellular response to angiotensin;GO:1904639|cellular response to resveratrol;GO:1905043|positive regulation of epithelium regeneration;GO:1990090|cellular response to nerve growth factor stimulus;GO:1990830|cellular response to leukemia inhibitory factor;GO:2000098|negative regulation of smooth muscle cell-matrix adhesion;GO:2000352|negative regulation of endothelial cell apoptotic process;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0042583|chromaffin granule;GO:0062023|collagen-containing extracellular matrix;GO:0070062|extracellular exosome;","GO:0002020|protease binding;GO:0004867|serine-type endopeptidase inhibitor activity;GO:0005102|signaling receptor binding;","K03982","SERPINE1, PAI1; plasminogen activator inhibitor 1"]
["ENSRNOG00000005266",16,1.328426568,210,13.50939202,0.098333557,-3.346172361,{"v":4.66199e-36,"d":"4.66E-36"},{"v":2.91675e-35,"d":"2.92E-35"},"down","yes","Amdhd1","protein_coding","chr7:28043716-28059156:-","gi|300796311|ref|NP_001178710.1|",2143,0,"probable imidazolonepropionase [Rattus norvegicus]","gi|300796310|ref|NM_001191781.1|",1290,0,"Rattus norvegicus amidohydrolase domain containing 1 (Amdhd1), mRNA","Q9DBA8",776,0,"Probable imidazolonepropionase","FN0740",234,{"v":5e-70,"d":"5.00E-70"},"COG1228","pfam13147","Amidohydro_4","Amidohydrolase. This family of enzymes are a part of a large metal dependent hydrolase superfamily. The family includes Adenine deaminase EC:3.5.4.2 that hydrolyses adenine to form hypoxanthine and ammonia. Adenine deaminases reaction is important for adenine utilisation as a purine and also as a nitrogen source. This family also includes dihydroorotase and N-acetylglucosamine-6-phosphate deacetylases, EC:3.5.1.25 These enzymes catalyse the reaction N-acetyl-D-glucosamine 6-phosphate + H2O <=> D-glucosamine 6-phosphate + acetate. This family includes the catalytic domain of urease alpha subunit. Dihydroorotases (EC:3.5.2.3) are also included.","GO:0006548|histidine catabolic process;GO:0019556|histidine catabolic process to glutamate and formamide;GO:0019557|histidine catabolic process to glutamate and formate;","GO:0005737|cytoplasm;","GO:0050480|imidazolonepropionase activity;","K01468","hutI, AMDHD1; imidazolonepropionase [EC:3.5.2.7]"]
["ENSRNOG00000067388",57,4.73251965,329,21.16471416,0.223604232,-2.160980603,{"v":1.48975e-35,"d":"1.49E-35"},{"v":9.19461e-35,"d":"9.19E-35"},"down","yes","ENSRNOG00000067388","protein_coding","chr9:45262374-45264366:-","gi|635071251|ref|XP_008004461.1|",771,{"v":2e-94,"d":"2.00E-94"},"PREDICTED: actin-related protein 2/3 complex subunit 5-like protein [Chlorocebus sabaeus]","gi|291045276|ref|NG_016699.1|",1115,0,"Rattus norvegicus actin related protein 2/3 complex, subunit 5-like, pseudogene 1 (Arpc5l-ps1) on chromosome 9","A1L108",291,{"v":6e-93,"d":"6.00E-93"},"Actin-related protein 2/3 complex subunit 5-like protein",".",".",".",".","pfam04699","P16-Arc","ARP2/3 complex 16 kDa subunit (p16-Arc). The Arp2/3 protein complex has been implicated in the control of actin polymerization. The human complex consists of seven subunits which include the actin related proteins Arp2 and Arp3, and five others referred to as p41-Arc, p34-Arc, p21-Arc, p20-Arc, and p16-Arc. The precise function of p16-Arc is currently unknown. Its structure consists of a single domain containing a bundle of seven alpha helices.",".",".",".",".","."]
["ENSRNOG00000032048",331,27.48182463,902,58.02605524,0.473611803,-1.07822306,{"v":2.49784e-35,"d":"2.50E-35"},{"v":1.53277E-34,"d":"1.53E-34"},"down","yes","Zfp462","protein_coding","chr5:69670328-69810327:+","gi|672052667|ref|XP_008761951.1|",12273,0,"PREDICTED: zinc finger protein 462 isoform X4 [Rattus norvegicus]","gi|672052666|ref|XM_008763729.1|",9819,0,"PREDICTED: Rattus norvegicus zinc finger protein 462 (Zfp462), transcript variant X6, mRNA","Q96JM2",3569,0,"Zinc finger protein 462",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0006325|chromatin organization;GO:0010468|regulation of gene expression;GO:0043392|negative regulation of DNA binding;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;",".","K24853","ZNF462; zinc finger protein 462"]
["ENSRNOG00000006019",64,5.313706274,343,22.0653403,0.240816874,-2.05399161,{"v":8.63277e-35,"d":"8.63E-35"},{"v":5.25703e-34,"d":"5.26E-34"},"down","yes","G0s2","protein_coding","chr13:104806156-104807451:-","gi|57526884|ref|NP_001009632.1|",427,{"v":3e-48,"d":"3.00E-48"},"G0/G1 switch protein 2 [Rattus norvegicus]","gi|57526883|ref|NM_001009632.1|",729,0,"Rattus norvegicus G0/G1switch 2 (G0s2), mRNA","Q5M840",169,{"v":9e-50,"d":"9.00E-50"},"G0/G1 switch protein 2",".",".",".",".","pfam15103","G0-G1_switch_2","G0/G1 switch protein 2. This family of proteins regulate apoptosis by binding to Bcl-2 and preventing the formation of the anti-apoptotic BAX-BCL2 heterodimers.","GO:0097191|extrinsic apoptotic signaling pathway;GO:0120162|positive regulation of cold-induced thermogenesis;GO:2001238|positive regulation of extrinsic apoptotic signaling pathway;","GO:0005739|mitochondrion;",".",".","."]
["ENSRNOG00000008709",256,21.25482509,755,48.56948083,0.437616889,-1.192259678,{"v":8.77006e-35,"d":"8.77E-35"},{"v":5.33556e-34,"d":"5.34E-34"},"down","yes","Arhgap32","protein_coding","chr8:30421515-30678454:+","gi|672022663|ref|XP_006226422.2|",10068,0,"PREDICTED: rho GTPase-activating protein 32 isoform X4 [Rattus norvegicus]","gi|672022666|ref|XM_008776684.1|",6304,0,"PREDICTED: Rattus norvegicus Rho GTPase activating protein 32 (Arhgap32), transcript variant X7, mRNA","Q811P8",3701,0,"Rho GTPase-activating protein 32",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0007264|small GTPase mediated signal transduction;GO:0050790|regulation of catalytic activity;","GO:0001650|fibrillar center;GO:0005654|nucleoplasm;GO:0005794|Golgi apparatus;GO:0005938|cell cortex;GO:0014069|postsynaptic density;GO:0015629|actin cytoskeleton;","GO:0005096|GTPase activator activity;GO:1901981|phosphatidylinositol phosphate binding;","K20647","ARHGAP32; Rho GTPase-activating protein 32"]
["ENSRNOG00000043387",291,24.16075821,821,52.81528975,0.457457648,-1.128289913,{"v":1.21745E-34,"d":"1.22E-34"},{"v":7.37867e-34,"d":"7.38E-34"},"down","yes","Cpe","protein_coding","chr16:25030276-25142233:+","gi|55249691|gb|AAH85762.1|",2182,0,"Carboxypeptidase E [Rattus norvegicus]","gi|55249690|gb|BC085762.1|",2090,0,"Rattus norvegicus carboxypeptidase E, mRNA (cDNA clone MGC:93638 IMAGE:7193151), complete cds","P15087",843,0,"Carboxypeptidase E","BH3831",57,8e-08,"COG2866","pfam00246","Peptidase_M14","Zinc carboxypeptidase.","GO:0003214|cardiac left ventricle morphogenesis;GO:0006518|peptide metabolic process;GO:0016055|Wnt signaling pathway;GO:0016485|protein processing;GO:0016486|peptide hormone processing;GO:0030070|insulin processing;GO:0030072|peptide hormone secretion;GO:0033366|protein localization to secretory granule;GO:0034230|enkephalin processing;GO:0043171|peptide catabolic process;GO:0072657|protein localization to membrane;GO:2000173|negative regulation of branching morphogenesis of a nerve;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005794|Golgi apparatus;GO:0030141|secretory granule;GO:0030425|dendrite;GO:0030658|transport vesicle membrane;GO:0030667|secretory granule membrane;GO:0031045|dense core granule;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0045121|membrane raft;GO:0097060|synaptic membrane;","GO:0004180|carboxypeptidase activity;GO:0004181|metallocarboxypeptidase activity;GO:0005515|protein binding;GO:0008270|zinc ion binding;GO:0019904|protein domain specific binding;GO:0042043|neurexin family protein binding;GO:0050839|cell adhesion molecule binding;GO:0050897|cobalt ion binding;","K01294","CPE; carboxypeptidase E [EC:3.4.17.10]"]
["ENSRNOG00000061215",220,18.26586532,680,43.74469797,0.417556096,-1.259958066,{"v":3.32126e-34,"d":"3.32E-34"},{"v":1.98843e-33,"d":"1.99E-33"},"down","yes","Crym","protein_coding","chr1:174560416-174575633:-","gi|16758840|ref|NP_446407.1|",1592,0,"ketimine reductase mu-crystallin [Rattus norvegicus]","gi|56789443|gb|BC088121.1|",732,0,"Rattus norvegicus crystallin, mu, mRNA (cDNA clone MGC:108623 IMAGE:7323247), complete cds","Q9QYU4",617,0,"Ketimine reductase mu-crystallin","MA3252",139,{"v":5E-36,"d":"5.00E-36"},"COG2423","pfam02423","OCD_Mu_crystall","Ornithine cyclodeaminase/mu-crystallin family. This family contains the bacterial Ornithine cyclodeaminase enzyme EC:4.3.1.12, which catalyses the deamination of ornithine to proline. This family also contains mu-Crystallin the major component of the eye lens in several Australian marsupials, mRNA for this protein has also been found in human retina.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006839|mitochondrial transport;GO:0007605|sensory perception of sound;GO:0009725|response to hormone;GO:0033280|response to vitamin D;GO:0042403|thyroid hormone metabolic process;GO:0070327|thyroid hormone transport;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;","GO:0003674|molecular_function;GO:0003714|transcription corepressor activity;GO:0042562|hormone binding;GO:0042803|protein homodimerization activity;GO:0047127|thiomorpholine-carboxylate dehydrogenase activity;GO:0050661|NADP binding;GO:0070324|thyroid hormone binding;","K18258","CRYM; thiomorpholine-carboxylate dehydrogenase [EC:1.5.1.25]"]
["ENSRNOG00000060867",106,8.800826016,440,28.3053928,0.310924002,-1.685366103,{"v":3.56776e-34,"d":"3.57E-34"},{"v":2.13202e-33,"d":"2.13E-33"},"down","yes","Rln1","protein_coding","chr1:227079966-227082882:-","gi|564333247|ref|XP_006231258.1|",899,{"v":1E-119,"d":"1.00E-119"},"PREDICTED: prorelaxin 1 isoform X1 [Rattus norvegicus]","gi|672040050|ref|XM_006231196.2|",781,0,"PREDICTED: Rattus norvegicus relaxin 1 (Rln1), transcript variant X1, mRNA","P01347",345,{"v":4e-119,"d":"4.00E-119"},"Prorelaxin 1",".",".",".",".","pfam00049","Insulin","Insulin/IGF/Relaxin family. Superfamily includes insulins; relaxins; insulin-like growth factor; and bombyxin. All are secreted regulatory hormones. Disulfide rich, all-alpha fold. Alignment includes B chain, linker (which is processed out of the final product), and A chain.","GO:0007188|adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007283|spermatogenesis;GO:0010749|regulation of nitric oxide mediated signal transduction;GO:0042127|regulation of cell proliferation;GO:0042981|regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0048589|developmental growth;GO:0050878|regulation of body fluid levels;GO:0060443|mammary gland morphogenesis;GO:0060618|nipple development;GO:0060736|prostate gland growth;","GO:0005576|extracellular region;","GO:0005102|signaling receptor binding;GO:0005179|hormone activity;","K21998","RLN1_2; relaxin 1/2"]
["ENSRNOG00000011718",227,18.84705194,687,44.19501103,0.426452025,-1.229544645,{"v":2.64035E-33,"d":"2.64E-33"},{"v":1.5418e-32,"d":"1.54E-32"},"down","yes","C1rl","protein_coding","chr4:157394200-157410134:+","gi|149049502|gb|EDM01956.1|",2619,0,"complement component 1, r subcomponent-like [Rattus norvegicus]","gi|50657415|ref|NM_001002804.1|",1378,0,"Rattus norvegicus complement component 1, r subcomponent-like (C1rl), mRNA","Q6IE64",954,0,"Complement C1r subcomponent-like protein","mlr3307",79,{"v":5E-15,"d":"5.00E-15"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;GO:0006958|complement activation, classical pathway;GO:0031638|zymogen activation;GO:0045087|innate immune response;","GO:0005615|extracellular space;GO:0072562|blood microparticle;","GO:0004252|serine-type endopeptidase activity;","K24791","C1RL; complement C1r subcomponent-like protein [EC:3.4.21.-]"]
["ENSRNOG00000018076",366,30.38775775,947,60.92092496,0.498806572,-1.003447621,{"v":4.4081e-33,"d":"4.41E-33"},{"v":2.56235e-32,"d":"2.56E-32"},"down","yes","Fmo5","protein_coding","chr2:185222204-185249693:+","gi|47477815|gb|AAH70883.1|",2871,0,"Flavin containing monooxygenase 5 [Rattus norvegicus]","gi|21426796|ref|NM_144739.1|",2634,0,"Rattus norvegicus flavin containing monooxygenase 5 (Fmo5), mRNA","Q8K4C0",1102,0,"Dimethylaniline monooxygenase [N-oxide-forming] 5","CC0774",257,{"v":6e-75,"d":"6.00E-75"},"COG2072","pfam00743","FMO-like","Flavin-binding monooxygenase-like. This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.","GO:0006805|xenobiotic metabolic process;GO:0070995|NADPH oxidation;GO:0090181|regulation of cholesterol metabolic process;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005829|cytosol;GO:0016021|integral component of membrane;","GO:0004031|aldehyde oxidase activity;GO:0004497|monooxygenase activity;GO:0004499|N,N-dimethylaniline monooxygenase activity;GO:0050660|flavin adenine dinucleotide binding;GO:0050661|NADP binding;","K00485","FMO; dimethylaniline monooxygenase (N-oxide forming) / hypotaurine monooxygenase [EC:1.14.13.8 1.8.1.-]"]
["ENSRNOG00000069713",337,27.9799846,893,57.4470813,0.487056678,-1.037838428,{"v":5.56822e-33,"d":"5.57E-33"},{"v":3.23083e-32,"d":"3.23E-32"},"down","yes","ENSRNOG00000069713","lncRNA","chrX:15395785-15398610:-","gi|149061698|gb|EDM12121.1|",421,{"v":5e-45,"d":"5.00E-45"},"rCG47580, partial [Rattus norvegicus]","gi|228480382|gb|AC122990.5|",1389,0,"Rattus norvegicus CH230-360O12 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P10273",129,{"v":1e-40,"d":"1.00E-40"},"Gag-Pol polyprotein",".",".",".",".","pfam00429","TLV_coat","ENV polyprotein (coat polyprotein).",".",".",".",".","."]
["ENSRNOG00000013851",268,22.25114502,762,49.0197939,0.453921636,-1.139484841,{"v":9.20597e-33,"d":"9.21E-33"},{"v":5.30784e-32,"d":"5.31E-32"},"down","yes","Spry4","protein_coding","chr18:30436443-30453004:-","gi|672083159|ref|XP_008770289.1|",1383,{"v":2e-173,"d":"2.00E-173"},"PREDICTED: protein sprouty homolog 4 isoform X1 [Rattus norvegicus]","gi|157817802|ref|NM_001106150.1|",4728,0,"Rattus norvegicus sprouty RTK signaling antagonist 4 (Spry4), mRNA","Q9WTP2",494,{"v":4E-160,"d":"4.00E-160"},"Protein sprouty homolog 4",".",".",".",".","pfam05210","Sprouty","Sprouty protein (Spry). This family consists of eukaryotic Sprouty protein homologues. Sprouty proteins have been revealed as inhibitors of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases. The sprouty gene has found to be expressed in the the brain, cochlea, nasal organs, teeth, salivary gland, lungs, digestive tract, kidneys and limb buds in mice.","GO:0040037|negative regulation of fibroblast growth factor receptor signaling pathway;GO:0043407|negative regulation of MAP kinase activity;GO:0046580|negative regulation of Ras protein signal transduction;GO:0048513|animal organ development;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:1900025|negative regulation of substrate adhesion-dependent cell spreading;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016020|membrane;","GO:0004860|protein kinase inhibitor activity;","K17385","SPRY4; protein sprouty homolog 4"]
["ENSRNOG00000011976",210,17.43559871,648,41.68612394,0.418259053,-1.257531329,{"v":1.39493E-32,"d":"1.39E-32"},{"v":8.02096e-32,"d":"8.02E-32"},"down","yes","Nudt7","protein_coding","chr19:42125711-42151081:+","gi|149038257|gb|EDL92617.1|",1339,0,"nudix (nucleoside diphosphate linked moiety X)-type motif 7 (predicted), isoform CRA_d [Rattus norvegicus]","gi|779927948|ref|NM_001305427.1|",866,0,"Rattus norvegicus nudix hydrolase 7 (Nudt7), transcript variant 2, mRNA","Q99P30",374,{"v":2e-127,"d":"2.00E-127"},"Peroxisomal coenzyme A diphosphatase NUDT7","RSc0937",88.6,{"v":2E-19,"d":"2.00E-19"},"COG0494","pfam00293","NUDIX","NUDIX domain.","GO:0009132|nucleoside diphosphate metabolic process;GO:0015938|coenzyme A catabolic process;GO:0036114|medium-chain fatty-acyl-CoA catabolic process;GO:0044580|butyryl-CoA catabolic process;GO:0046356|acetyl-CoA catabolic process;GO:0050873|brown fat cell differentiation;GO:1901289|succinyl-CoA catabolic process;GO:1902858|propionyl-CoA metabolic process;GO:1902859|propionyl-CoA catabolic process;GO:2001294|malonyl-CoA catabolic process;","GO:0005777|peroxisome;","GO:0000287|magnesium ion binding;GO:0003986|acetyl-CoA hydrolase activity;GO:0010945|CoA pyrophosphatase activity;GO:0030145|manganese ion binding;GO:0030515|snoRNA binding;","K17879","NUDT7; peroxisomal coenzyme A diphosphatase NUDT7 [EC:3.6.1.-]"]
["ENSRNOG00000032699",98,8.136612731,410,26.37547966,0.308491555,-1.696697099,{"v":3.01274e-32,"d":"3.01E-32"},{"v":1.71233E-31,"d":"1.71E-31"},"down","yes","Ttyh1","protein_coding","chr1:70053324-70071845:-","gi|157819361|ref|NP_001099695.1|",1592,0,"protein tweety homolog 1 [Rattus norvegicus]","gi|672034966|ref|XM_006228216.2|",3076,0,"PREDICTED: Rattus norvegicus tweety family member 1 (Ttyh1), transcript variant X1, mRNA","P0C5X8",617,0,"Protein tweety homolog 1",".",".",".",".","pfam04906","Tweety","Tweety. The tweety (tty) gene has not been characterized at the protein level. However, it is thought to form a membrane protein with five potential membrane-spanning regions. A number of potential functions have been suggested in.","GO:0000278|mitotic cell cycle;GO:0006821|chloride transport;GO:0031589|cell-substrate adhesion;GO:0046847|filopodium assembly;GO:0098609|cell-cell adhesion;","GO:0005886|plasma membrane;GO:0030868|smooth endoplasmic reticulum membrane;GO:0031527|filopodium membrane;GO:0032433|filopodium tip;GO:0034707|chloride channel complex;GO:0045202|synapse;","GO:0005229|intracellular calcium activated chloride channel activity;GO:0005509|calcium ion binding;GO:0072320|volume-sensitive chloride channel activity;","K22641","TTYH; protein tweety"]
["ENSRNOG00000005589",287,23.82865157,793,51.01403748,0.467099895,-1.098196973,{"v":3.69809e-32,"d":"3.70E-32"},{"v":2.09442e-31,"d":"2.09E-31"},"down","yes","Dhrs7","protein_coding","chr6:91251323-91347892:-","gi|406035360|ref|NP_001258323.1|",1697,0,"uncharacterized protein LOC299135 [Rattus norvegicus]","gi|406035359|ref|NM_001271394.1|",1282,0,"Rattus norvegicus similar to Dehydrogenase/reductase SDR family member 7 precursor (Retinal short-chain dehydrogenase/reductase 4) (RGD1565002), mRNA","Q9CXR1",607,0,"Dehydrogenase/reductase SDR family member 7",".",".",".",".","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.",".",".","GO:0016491|oxidoreductase activity;","K11165","DHRS7; dehydrogenase/reductase SDR family member 7 [EC:1.1.-.-]"]
["ENSRNOG00000042536",98,8.136612731,408,26.24681878,0.310003768,-1.689642342,{"v":6.40623e-32,"d":"6.41E-32"},{"v":3.61218e-31,"d":"3.61E-31"},"down","yes","Pde4d","protein_coding","chr2:40019933-41525884:+","gi|568984459|ref|XP_006517708.1|",3690,0,"PREDICTED: cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X3 [Mus musculus]","gi|880862234|ref|XM_005065552.2|",2896,0,"PREDICTED: Mesocricetus auratus phosphodiesterase 4D, cAMP-specific (Pde4d), transcript variant X4, mRNA","P14270",1331,0,"cAMP-specific 3',5'-cyclic phosphodiesterase 4D",".",".",".",".","pfam00233","PDEase_I","3'5'-cyclic nucleotide phosphodiesterase.","GO:0001934|positive regulation of protein phosphorylation;GO:0002027|regulation of heart rate;GO:0006198|cAMP catabolic process;GO:0006939|smooth muscle contraction;GO:0007165|signal transduction;GO:0007568|aging;GO:0007613|memory;GO:0008277|regulation of G protein-coupled receptor signaling pathway;GO:0010469|regulation of signaling receptor activity;GO:0010880|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0014911|positive regulation of smooth muscle cell migration;GO:0022409|positive regulation of cell-cell adhesion;GO:0030324|lung development;GO:0030593|neutrophil chemotaxis;GO:0032729|positive regulation of interferon-gamma production;GO:0032743|positive regulation of interleukin-2 production;GO:0032754|positive regulation of interleukin-5 production;GO:0033137|negative regulation of peptidyl-serine phosphorylation;GO:0034622|cellular protein-containing complex assembly;GO:0035264|multicellular organism growth;GO:0043949|regulation of cAMP-mediated signaling;GO:0043951|negative regulation of cAMP-mediated signaling;GO:0045822|negative regulation of heart contraction;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0050852|T cell receptor signaling pathway;GO:0050900|leukocyte migration;GO:0060314|regulation of ryanodine-sensitive calcium-release channel activity;GO:0061028|establishment of endothelial barrier;GO:0071222|cellular response to lipopolysaccharide;GO:0071320|cellular response to cAMP;GO:0071872|cellular response to epinephrine stimulus;GO:0071875|adrenergic receptor signaling pathway;GO:0086004|regulation of cardiac muscle cell contraction;GO:0086024|adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate;GO:1901898|negative regulation of relaxation of cardiac muscle;","GO:0005634|nucleus;GO:0005794|Golgi apparatus;GO:0005813|centrosome;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005891|voltage-gated calcium channel complex;GO:0016020|membrane;GO:0016324|apical plasma membrane;GO:0030016|myofibril;GO:0032991|protein-containing complex;GO:0034704|calcium channel complex;GO:0034705|potassium channel complex;GO:0048471|perinuclear region of cytoplasm;","GO:0004112|cyclic-nucleotide phosphodiesterase activity;GO:0004114|3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0004115|3',5'-cyclic-AMP phosphodiesterase activity;GO:0005515|protein binding;GO:0019899|enzyme binding;GO:0030552|cAMP binding;GO:0031698|beta-2 adrenergic receptor binding;GO:0044325|ion channel binding;GO:0046872|metal ion binding;GO:0051117|ATPase binding;GO:0097110|scaffold protein binding;GO:1901363|heterocyclic compound binding;","K13293","PDE4; cAMP-specific phosphodiesterase 4 [EC:3.1.4.53]"]
["ENSRNOG00000050404",115,9.54806596,443,28.49838412,0.335038854,-1.577599681,{"v":1.94631e-31,"d":"1.95E-31"},{"v":1.08217e-30,"d":"1.08E-30"},"down","yes","Pmepa1","protein_coding","chr3:162012751-162060454:-","gi|564344754|ref|XP_006235751.1|",1186,{"v":6E-158,"d":"6.00E-158"},"PREDICTED: transmembrane prostate androgen-induced protein isoform X1 [Rattus norvegicus]","gi|119508427|ref|NM_022995.3|",1154,0,"Mus musculus prostate transmembrane protein, androgen induced 1 (Pmepa1), mRNA","Q9D7R2",446,{"v":8e-154,"d":"8.00E-154"},"Protein TMEPAI",".",".",".",".","pfam15449","Retinal","Retinal protein. This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.","GO:0008150|biological_process;GO:0010991|negative regulation of SMAD protein complex assembly;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0060394|negative regulation of pathway-restricted SMAD protein phosphorylation;","GO:0000139|Golgi membrane;GO:0005575|cellular_component;GO:0010008|endosome membrane;GO:0016021|integral component of membrane;GO:0031901|early endosome membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0003674|molecular_function;GO:0050699|WW domain binding;GO:0070412|R-SMAD binding;",".","."]
["ENSRNOG00000025273",179,14.86177223,577,37.11866283,0.400385442,-1.320538575,{"v":2.28741e-31,"d":"2.29E-31"},{"v":1.26741e-30,"d":"1.27E-30"},"down","yes","AABR07068728.1","protein_coding","chr9:108329669-108747774:+","gi|569000585|ref|XP_006524479.1|",3049,0,"PREDICTED: lethal(3)malignant brain tumor-like protein 4 isoform X1 [Mus musculus]","gi|569000586|ref|XM_006524417.1|",2080,0,"PREDICTED: Mus musculus l(3)mbt-like 4 (Drosophila) (L3mbtl4), transcript variant X2, mRNA","B1B1A0",1170,0,"Lethal(3)malignant brain tumor-like protein 4",".",".",".",".","pfam02820","MBT","mbt repeat. The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.",".",".",".",".","."]
["ENSRNOG00000017637",17,1.411453229,192,12.35144413,0.114274348,-3.129426503,{"v":2.56182e-31,"d":"2.56E-31"},{"v":1.41333E-30,"d":"1.41E-30"},"down","yes","Fbp2","protein_coding","chr17:2236336-2253698:+","gi|537210347|gb|ERE80540.1|",1820,0,"fructose-1,6-bisphosphatase isozyme 2-like protein [Cricetulus griseus]","gi|16758953|ref|NM_053716.1|",1259,0,"Rattus norvegicus fructose-bisphosphatase 2 (Fbp2), mRNA","Q9Z1N1",694,0,"Fructose-1,6-bisphosphatase isozyme 2","VC2544",301,{"v":9e-98,"d":"9.00E-98"},"COG0158","pfam00316","FBPase","Fructose-1-6-bisphosphatase.","GO:0005986|sucrose biosynthetic process;GO:0006000|fructose metabolic process;GO:0006002|fructose 6-phosphate metabolic process;GO:0006094|gluconeogenesis;GO:0016311|dephosphorylation;GO:0030388|fructose 1,6-bisphosphate metabolic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0030018|Z disc;GO:0030054|cell junction;","GO:0042132|fructose 1,6-bisphosphate 1-phosphatase activity;GO:0042802|identical protein binding;GO:0046872|metal ion binding;","K03841","FBP, fbp; fructose-1,6-bisphosphatase I [EC:3.1.3.11]"]
["ENSRNOG00000004330",82,6.808186163,367,23.60927081,0.288369184,-1.794011092,{"v":2.95552e-31,"d":"2.96E-31"},{"v":1.62493e-30,"d":"1.62E-30"},"down","yes","Chrdl1","protein_coding","chrX:106889125-106992921:-","gi|41054820|ref|NP_955796.1|",2791,0,"chordin-like protein 1 [Rattus norvegicus]","gi|672088215|ref|XM_006257373.2|",4098,0,"PREDICTED: Rattus norvegicus chordin-like 1 (Chrdl1), transcript variant X1, mRNA","Q76LD0",929,0,"Chordin-like protein 1",".",".",".",".","pfam00093","VWC","von Willebrand factor type C domain. The high cutoff was used to prevent overlap with pfam00094.","GO:0001503|ossification;GO:0001654|eye development;GO:0001709|cell fate determination;GO:0030182|neuron differentiation;GO:0030514|negative regulation of BMP signaling pathway;","GO:0005576|extracellular region;",".","K24520","CHRDL1; chordin-like protein 1"]
["ENSRNOG00000069743",92,7.638452768,389,25.02454045,0.305238483,-1.711991233,{"v":4.73647e-31,"d":"4.74E-31"},{"v":2.57968e-30,"d":"2.58E-30"},"down","yes","Nxpe5l1","protein_coding","chr12:17186134-17196403:+","gi|672072443|ref|XP_008767296.1|",2942,0,"PREDICTED: NXPE family member 3-like isoform X2 [Rattus norvegicus]","gi|672072442|ref|XM_008769074.1|",1656,0,"PREDICTED: Rattus norvegicus neurexophilin and PC-esterase domain family, member 5 (Nxpe5), transcript variant X2, mRNA","A2VDP6",328,{"v":7e-103,"d":"7.00E-103"},"NXPE family member 3",".",".",".",".","pfam06312","Neurexophilin","Neurexophilin. This family consists of mammalian neurexophilin proteins. Mammalian brains contain four different neurexophilin proteins. Neurexophilins form a family of related glycoproteins that are proteolytically processed after synthesis and bind to alpha-neurexins. The structure and characteristics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins.",".",".",".",".","."]
["ENSRNOG00000036918",291,24.16075821,791,50.8853766,0.474807495,-1.074585385,{"v":4.99856e-31,"d":"5.00E-31"},{"v":2.71549E-30,"d":"2.72E-30"},"down","yes","Etfbkmt","protein_coding","chr4:182140559-182150305:+","gi|38454282|ref|NP_942067.1|",1359,0,"protein N-lysine methyltransferase METTL20 [Rattus norvegicus]","gi|38454281|ref|NM_198772.1|",1572,0,"Rattus norvegicus electron transfer flavoprotein beta subunit lysine methyltransferase (Etfbkmt), mRNA","Q6P7Q0",528,0,"Electron transfer flavoprotein beta subunit lysine methyltransferase","SMc03226",133,{"v":2e-34,"d":"2.00E-34"},"COG3897","pfam06325","PrmA","Ribosomal protein L11 methyltransferase (PrmA). This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.","GO:0018022|peptidyl-lysine methylation;GO:0018023|peptidyl-lysine trimethylation;GO:1904733|negative regulation of electron transfer activity;GO:1904736|negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase;","GO:0005737|cytoplasm;GO:0005759|mitochondrial matrix;GO:0032991|protein-containing complex;","GO:0008276|protein methyltransferase activity;GO:0016279|protein-lysine N-methyltransferase activity;GO:0031072|heat shock protein binding;","K22843","ETFBKMT, METTL20; ETFB lysine methyltransferase [EC:2.1.1.-]"]
["ENSRNOG00000001926",330,27.39879797,861,55.38850728,0.494665759,-1.015474057,{"v":8.49149e-31,"d":"8.49E-31"},{"v":4.59352e-30,"d":"4.59E-30"},"down","yes","Cldn1","protein_coding","chr11:74421569-74436724:+","gi|62296502|sp|P56745.2|CLD1_RAT",883,{"v":2E-107,"d":"2.00E-107"},"RecName: Full=Claudin-1","gi|61889098|ref|NM_031699.2|",3171,0,"Rattus norvegicus claudin 1 (Cldn1), mRNA","P56745",344,{"v":7e-109,"d":"7.00E-109"},"Claudin-1",".",".",".",".","pfam00822","PMP22_Claudin","PMP-22/EMP/MP20/Claudin family.","GO:0007155|cell adhesion;GO:0007568|aging;GO:0008065|establishment of blood-nerve barrier;GO:0009636|response to toxic substance;GO:0016338|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;GO:0030335|positive regulation of cell migration;GO:0032496|response to lipopolysaccharide;GO:0034331|cell junction maintenance;GO:0042538|hyperosmotic salinity response;GO:0045216|cell-cell junction organization;GO:0045471|response to ethanol;GO:0046718|viral entry into host cell;GO:0051259|protein complex oligomerization;GO:0060054|positive regulation of epithelial cell proliferation involved in wound healing;GO:0061436|establishment of skin barrier;GO:0061772|drug transport across blood-nerve barrier;GO:0070673|response to interleukin-18;GO:0070830|bicellular tight junction assembly;GO:0071284|cellular response to lead ion;GO:0071346|cellular response to interferon-gamma;GO:0071356|cellular response to tumor necrosis factor;GO:0071548|response to dexamethasone;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0090303|positive regulation of wound healing;GO:0090557|establishment of endothelial intestinal barrier;GO:0097421|liver regeneration;GO:1903348|positive regulation of bicellular tight junction assembly;GO:1903545|cellular response to butyrate;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005911|cell-cell junction;GO:0005923|bicellular tight junction;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0016328|lateral plasma membrane;GO:0030054|cell junction;GO:0032991|protein-containing complex;GO:0070160|tight junction;","GO:0001618|virus receptor activity;GO:0005198|structural molecule activity;GO:0042802|identical protein binding;","K06087","CLDN; claudin"]
["ENSRNOG00000021478",115,9.54806596,438,28.17673192,0.338863499,-1.561223852,{"v":1.17158E-30,"d":"1.17E-30"},{"v":6.3217e-30,"d":"6.32E-30"},"down","yes","Tpd52l1","protein_coding","chr1:26172170-26291109:+","gi|112983804|ref|NP_001037760.1|",859,{"v":8e-110,"d":"8.00E-110"},"tumor protein D53 [Rattus norvegicus]","gi|672034060|ref|XM_006227737.2|",1571,0,"PREDICTED: Rattus norvegicus tumor protein D52-like 1 (Tpd52l1), transcript variant X2, mRNA","O54818",298,{"v":2e-96,"d":"2.00E-96"},"Tumor protein D53",".",".",".",".","pfam04201","TPD52","tumor protein D52 family. The hD52 gene was originally identified through its elevated expression level in human breast carcinoma. Cloning of D52 homologues from other species has indicated that D52 may play roles in calcium-mediated signal transduction and cell proliferation. Two human homologues of hD52, hD53 and hD54, have also been identified, demonstrating the existence of a novel gene/protein family. These proteins have an amino terminal coiled-coil that allows members to form homo- and heterodimers with each other.","GO:0000086|G2/M transition of mitotic cell cycle;GO:0043406|positive regulation of MAP kinase activity;GO:0046330|positive regulation of JNK cascade;GO:2001235|positive regulation of apoptotic signaling pathway;","GO:0005737|cytoplasm;GO:0048471|perinuclear region of cytoplasm;","GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;",".","."]
["ENSRNOG00000012436",323,26.81761135,846,54.4235507,0.492757474,-1.021050342,{"v":1.50346E-30,"d":"1.50E-30"},{"v":8.08516e-30,"d":"8.09E-30"},"down","yes","Adh6","protein_coding","chr2:226797303-226808892:+","gi|21070353|gb|AAM34269.1|AF508795_1",1809,0,"ADH-like protein [Rattus norvegicus]","gi|685156909|ref|NM_019286.4|",1806,0,"Rattus norvegicus alcohol dehydrogenase 1 (class I) (Adh1), mRNA","P06757",701,0,"Alcohol dehydrogenase 1","YPO1502",366,{"v":5e-120,"d":"5.00E-120"},"COG1062","pfam08240","ADH_N","Alcohol dehydrogenase GroES-like domain. This is the catalytic domain of alcohol dehydrogenases. Many of them contain an inserted zinc binding domain. This domain has a GroES-like structure.","GO:0001523|retinoid metabolic process;GO:0006068|ethanol catabolic process;GO:0006069|ethanol oxidation;GO:0008150|biological_process;GO:0031100|animal organ regeneration;GO:0032526|response to retinoic acid;GO:0032570|response to progesterone;GO:0033574|response to testosterone;GO:0042572|retinol metabolic process;GO:0042573|retinoic acid metabolic process;GO:0046186|acetaldehyde biosynthetic process;GO:0048149|behavioral response to ethanol;GO:0048545|response to steroid hormone;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0003674|molecular_function;GO:0004022|alcohol dehydrogenase (NAD) activity;GO:0004024|alcohol dehydrogenase activity, zinc-dependent;GO:0004745|retinol dehydrogenase activity;GO:0008270|zinc ion binding;GO:0016491|oxidoreductase activity;GO:0035276|ethanol binding;GO:0042802|identical protein binding;GO:0051287|NAD binding;GO:0097159|organic cyclic compound binding;","K13951","ADH1_7; alcohol dehydrogenase 1/7 [EC:1.1.1.1]K13951; K13952"]
["ENSRNOG00000025394",302,25.07405148,807,51.91466362,0.482985918,-1.049946968,{"v":1.64969E-30,"d":"1.65E-30"},{"v":8.86409e-30,"d":"8.86E-30"},"down","yes","Tanc1","protein_coding","chr3:44134016-44331627:+","gi|564340980|ref|XP_006234266.1|",8878,0,"PREDICTED: protein TANC1 isoform X1 [Rattus norvegicus]","gi|564340979|ref|XM_006234204.1|",5738,0,"PREDICTED: Rattus norvegicus tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 (Tanc1), transcript variant X1, mRNA","Q6F6B3",3363,0,"Protein TANC1","all2748",133,{"v":1e-31,"d":"1.00E-31"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0007520|myoblast fusion;GO:0008542|visual learning;GO:0097062|dendritic spine maintenance;GO:0099175|regulation of postsynapse organization;","GO:0030425|dendrite;GO:0043025|neuronal cell body;GO:0043679|axon terminus;GO:0098978|glutamatergic synapse;GO:0099092|postsynaptic density, intracellular component;","GO:0005515|protein binding;",".","."]
["ENSRNOG00000019584",42,3.487119742,261,16.79024437,0.207687254,-2.267515418,{"v":3.39269E-30,"d":"3.39E-30"},{"v":1.79728E-29,"d":"1.80E-29"},"down","yes","Dlk1","protein_coding","chr6:128410316-128417522:+","gi|16758572|ref|NP_446196.1|",1896,0,"protein delta homolog 1 precursor [Rattus norvegicus]","gi|189442750|gb|BC167752.1|",1562,0,"Rattus norvegicus delta-like 1 homolog (Drosophila), mRNA (cDNA clone MGC:187346 IMAGE:8365650), complete cds","Q09163",696,0,"Protein delta homolog 1",".",".",".",".","pfam00008","EGF","EGF-like domain. There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.","GO:0001503|ossification;GO:0001649|osteoblast differentiation;GO:0001819|positive regulation of cytokine production;GO:0009791|post-embryonic development;GO:0010468|regulation of gene expression;GO:0030154|cell differentiation;GO:0030282|bone mineralization;GO:0035264|multicellular organism growth;GO:0045599|negative regulation of fat cell differentiation;GO:0045746|negative regulation of Notch signaling pathway;GO:0045780|positive regulation of bone resorption;GO:0048706|embryonic skeletal system development;GO:1905563|negative regulation of vascular endothelial cell proliferation;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0009897|external side of plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;GO:0005515|protein binding;","K24461","DLK1; protein delta homolog 1"]
["ENSRNOG00000003832",143,11.87281246,494,31.77923646,0.373602823,-1.420422739,{"v":4.36771E-30,"d":"4.37E-30"},{"v":2.30997e-29,"d":"2.31E-29"},"down","yes","Vash2","protein_coding","chr13:102529719-102560391:-","gi|564382294|ref|XP_006250525.1|",1948,0,"PREDICTED: vasohibin-2 isoform X2 [Rattus norvegicus]","gi|672075185|ref|XM_006250463.2|",3656,0,"PREDICTED: Rattus norvegicus vasohibin 2 (Vash2), transcript variant X3, mRNA","Q8C5G2",635,0,"Vasohibin-2",".",".",".",".","pfam14822","Vasohibin","Vasohibin. This family of proteins function as angiogenesis inhibitors in animals.","GO:0000768|syncytium formation by plasma membrane fusion;GO:0001938|positive regulation of endothelial cell proliferation;GO:0006508|proteolysis;GO:0045765|regulation of angiogenesis;GO:0045766|positive regulation of angiogenesis;GO:0060674|placenta blood vessel development;GO:0060711|labyrinthine layer development;GO:0060716|labyrinthine layer blood vessel development;GO:0061564|axon development;GO:0140253|cell-cell fusion;","GO:0005737|cytoplasm;","GO:0003779|actin binding;GO:0004181|metallocarboxypeptidase activity;GO:0008017|microtubule binding;","K23355","VASH; tubulinyl-Tyr carboxypeptidase [EC:3.4.17.17]"]
["ENSRNOG00000024346",53,4.400413008,289,18.59149664,0.236689552,-2.078932072,{"v":5.15682E-30,"d":"5.16E-30"},{"v":2.71385e-29,"d":"2.71E-29"},"down","yes","Plet1","protein_coding","chr8:50841854-50853659:+","gi|62079153|ref|NP_001014231.1|",945,{"v":2e-122,"d":"2.00E-122"},"placenta-expressed transcript 1 protein precursor [Rattus norvegicus]","gi|298910792|emb|FQ228964.1|",1325,0,"Rattus norvegicus TL0ADA50YB20 mRNA sequence","Q5HZW7",351,{"v":3e-117,"d":"3.00E-117"},"Placenta-expressed transcript 1 protein",".",".",".",".","pfam02112","PDEase_II","cAMP phosphodiesterases class-II.","GO:0001953|negative regulation of cell-matrix adhesion;GO:0030154|cell differentiation;GO:0030335|positive regulation of cell migration;GO:0035313|wound healing, spreading of epidermal cells;","GO:0009897|external side of plasma membrane;GO:0016324|apical plasma membrane;GO:0031225|anchored component of membrane;",".",".","."]
["ENSRNOG00000068250",60,4.981599631,306,19.68511408,0.253064301,-1.982424091,{"v":6.8954e-30,"d":"6.90E-30"},{"v":3.61986E-29,"d":"3.62E-29"},"down","yes","ENSRNOG00000068250","lncRNA","chr9:105766167-105772713:-","gi|377837122|ref|XP_003688804.1|",541,{"v":3e-55,"d":"3.00E-55"},"PREDICTED: sperm motility kinase W [Mus musculus]","gi|186965653|gb|AC103346.5|",330,{"v":7e-170,"d":"7.00E-170"},"Rattus norvegicus BAC CH230-2K7 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q8C0V7",208,{"v":2E-55,"d":"2.00E-55"},"Putative sperm motility kinase W",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.",".",".",".",".","."]
["ENSRNOG00000001627",285,23.66259825,769,49.47010696,0.478321146,-1.063948523,{"v":9.42259e-30,"d":"9.42E-30"},{"v":4.92231e-29,"d":"4.92E-29"},"down","yes","Abi3bp","protein_coding","chr11:43913043-44128929:-","gi|568995590|ref|XP_006522315.1|",6588,0,"PREDICTED: target of Nesh-SH3 isoform X2 [Mus musculus]","gi|672025990|ref|XM_008776584.1|",2137,0,"PREDICTED: Rattus norvegicus ABI family, member 3 (NESH) binding protein (Abi3bp), transcript variant X3, mRNA","Q7Z7G0",822,0,"Target of Nesh-SH3",".",".",".",".","pfam05109","Herpes_BLLF1","Herpes virus major outer envelope glycoprotein (BLLF1). This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralizing antibodies in vivo.","GO:0002357|defense response to tumor cell;GO:0008285|negative regulation of cell proliferation;GO:0010811|positive regulation of cell-substrate adhesion;GO:0030198|extracellular matrix organization;GO:0061001|regulation of dendritic spine morphogenesis;GO:0099151|regulation of postsynaptic density assembly;GO:1904597|negative regulation of connective tissue replacement involved in inflammatory response wound healing;GO:1905209|positive regulation of cardiocyte differentiation;GO:2000249|regulation of actin cytoskeleton reorganization;GO:2000774|positive regulation of cellular senescence;","GO:0005614|interstitial matrix;GO:0014069|postsynaptic density;GO:0030027|lamellipodium;GO:0031012|extracellular matrix;GO:0043197|dendritic spine;GO:0043198|dendritic shaft;","GO:0005518|collagen binding;GO:0005539|glycosaminoglycan binding;GO:0008201|heparin binding;GO:0051015|actin filament binding;","K24477","ABI3BP; target of Nesh-SH3"]
["ENSRNOG00000012928",326,27.06669133,842,54.16622895,0.499696801,-1.000875113,{"v":1.75589e-29,"d":"1.76E-29"},{"v":9.12049e-29,"d":"9.12E-29"},"down","yes","Prmt9","protein_coding","chr19:30380124-30414458:-","gi|300797830|ref|NP_001178528.1|",4187,0,"putative protein arginine N-methyltransferase 9 [Rattus norvegicus]","gi|300797829|ref|NM_001191599.1|",2434,0,"Rattus norvegicus protein arginine methyltransferase 9 (Prmt9), mRNA","Q3U3W5",1503,0,"Protein arginine N-methyltransferase 9",".",".",".",".","pfam13414","TPR_11","TPR repeat.","GO:0006397|mRNA processing;GO:0019918|peptidyl-arginine methylation, to symmetrical-dimethyl arginine;","GO:0005737|cytoplasm;","GO:0016274|protein-arginine N-methyltransferase activity;GO:0035241|protein-arginine omega-N monomethyltransferase activity;GO:0035243|protein-arginine omega-N symmetric methyltransferase activity;","K19737","PRMT9; type II protein arginine methyltransferase [EC:2.1.1.320]"]
["ENSRNOG00000029148",227,18.84705194,654,42.07210657,0.447970246,-1.158525182,{"v":4.49211e-29,"d":"4.49E-29"},{"v":2.30337e-28,"d":"2.30E-28"},"down","yes","Pdgfd","protein_coding","chr8:3488423-3722395:+","gi|25742601|ref|NP_076452.1|",1881,0,"platelet-derived growth factor D precursor [Rattus norvegicus]","gi|755528236|ref|XM_006509885.2|",1465,0,"PREDICTED: Mus musculus platelet-derived growth factor, D polypeptide (Pdgfd), transcript variant X1, mRNA","Q9EQT1",729,0,"Platelet-derived growth factor D",".",".",".",".","pfam00431","CUB","CUB domain.","GO:0008284|positive regulation of cell proliferation;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0030335|positive regulation of cell migration;GO:0031954|positive regulation of protein autophosphorylation;GO:0036120|cellular response to platelet-derived growth factor stimulus;GO:0043406|positive regulation of MAP kinase activity;GO:0048008|platelet-derived growth factor receptor signaling pathway;GO:0048146|positive regulation of fibroblast proliferation;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0050730|regulation of peptidyl-tyrosine phosphorylation;GO:0051781|positive regulation of cell division;GO:0070301|cellular response to hydrogen peroxide;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071230|cellular response to amino acid stimulus;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0071673|positive regulation of smooth muscle cell chemotaxis;GO:0072126|positive regulation of glomerular mesangial cell proliferation;GO:2000439|positive regulation of monocyte extravasation;","GO:0005615|extracellular space;GO:0016020|membrane;","GO:0003674|molecular_function;GO:0005161|platelet-derived growth factor receptor binding;GO:0008083|growth factor activity;GO:0070851|growth factor receptor binding;","K05450","PDGFC_D; platelet derived growth factor C/D"]
["ENSRNOG00000006116",145,12.03886578,488,31.39325383,0.383485759,-1.382755091,{"v":1.27398e-28,"d":"1.27E-28"},{"v":6.4548e-28,"d":"6.45E-28"},"down","yes","Hk2","protein_coding","chr4:115234509-115283530:-","gi|7549765|ref|NP_036867.1|",4892,0,"hexokinase-2 [Rattus norvegicus]","gi|402692979|ref|NM_012735.2|",3630,0,"Rattus norvegicus hexokinase 2 (Hk2), mRNA","P27881",1889,0,"Hexokinase-2","SPAC24H6.04",282,{"v":1e-82,"d":"1.00E-82"},"COG5026","pfam03727","Hexokinase_2","Hexokinase. Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam00349. Some members of the family have two copies of each of these domains.","GO:0001666|response to hypoxia;GO:0001678|cellular glucose homeostasis;GO:0002931|response to ischemia;GO:0006002|fructose 6-phosphate metabolic process;GO:0006006|glucose metabolic process;GO:0006007|glucose catabolic process;GO:0006096|glycolytic process;GO:0007595|lactation;GO:0008637|apoptotic mitochondrial changes;GO:0035795|negative regulation of mitochondrial membrane permeability;GO:0045766|positive regulation of angiogenesis;GO:0046324|regulation of glucose import;GO:0046835|carbohydrate phosphorylation;GO:0051156|glucose 6-phosphate metabolic process;GO:0072655|establishment of protein localization to mitochondrion;GO:0072656|maintenance of protein location in mitochondrion;GO:1904925|positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization;GO:1990830|cellular response to leukemia inhibitory factor;GO:2000378|negative regulation of reactive oxygen species metabolic process;","GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0005813|centrosome;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016529|sarcoplasmic reticulum;GO:0043231|intracellular membrane-bounded organelle;","GO:0004340|glucokinase activity;GO:0004396|hexokinase activity;GO:0005524|ATP binding;GO:0005536|glucose binding;GO:0008865|fructokinase activity;GO:0019158|mannokinase activity;","K00844","HK; hexokinase [EC:2.7.1.1]"]
["ENSRNOG00000001517",173,14.36361227,544,34.99575837,0.410438663,-1.284761457,{"v":1.67429e-28,"d":"1.67E-28"},{"v":8.44953e-28,"d":"8.45E-28"},"down","yes","Pdk1","protein_coding","chr3:56705871-56733038:+","gi|59709473|ref|NP_446278.2|",2153,0,"pyruvate dehydrogenase kinase, isozyme 1 precursor [Rattus norvegicus]","gi|59709472|ref|NM_053826.2|",1579,0,"Rattus norvegicus pyruvate dehydrogenase kinase 1 (Pdk1), mRNA","Q63065",832,0,"[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial","SPAC644.11c",196,{"v":1e-55,"d":"1.00E-55"},"COG0642","pfam10436","BCDHK_Adom3","Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase. Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal.","GO:0006006|glucose metabolic process;GO:0006468|protein phosphorylation;GO:0007166|cell surface receptor signaling pathway;GO:0008283|cell proliferation;GO:0008631|intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0010510|regulation of acetyl-CoA biosynthetic process from pyruvate;GO:0010906|regulation of glucose metabolic process;GO:0018105|peptidyl-serine phosphorylation;GO:0097411|hypoxia-inducible factor-1alpha signaling pathway;","GO:0005739|mitochondrion;GO:0005967|mitochondrial pyruvate dehydrogenase complex;GO:0045254|pyruvate dehydrogenase complex;","GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0004740|pyruvate dehydrogenase (acetyl-transferring) kinase activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;","K12077","PDK1; pyruvate dehydrogenase kinase isoform 1 [EC:2.7.11.2]"]
["ENSRNOG00000014555",104,8.634772695,399,25.66784484,0.336404274,-1.571732062,{"v":2.45956E-28,"d":"2.46E-28"},{"v":1.23638E-27,"d":"1.24E-27"},"down","yes","Aox4","protein_coding","chr9:59664809-59818169:+","gi|564368520|ref|XP_006245049.1|",6660,0,"PREDICTED: aldehyde oxidase 4 isoform X1 [Rattus norvegicus]","gi|672065176|ref|XM_006244987.2|",4176,0,"PREDICTED: Rattus norvegicus aldehyde oxidase 4 (Aox4), transcript variant X1, mRNA","Q5QE79",2564,0,"Aldehyde oxidase 4","PA1523",516,{"v":1e-160,"d":"1.00E-160"},"COG4631","pfam02738","Ald_Xan_dh_C2","Molybdopterin-binding domain of aldehyde dehydrogenase.","GO:0006805|xenobiotic metabolic process;","GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004031|aldehyde oxidase activity;GO:0005506|iron ion binding;GO:0016491|oxidoreductase activity;GO:0042803|protein homodimerization activity;GO:0043546|molybdopterin cofactor binding;GO:0050250|retinal oxidase activity;GO:0050660|flavin adenine dinucleotide binding;GO:0051287|NAD binding;GO:0051537|2 iron, 2 sulfur cluster binding;GO:0071949|FAD binding;GO:0102797|geranial:oxygen oxidoreductase activity;GO:0102798|heptaldehyde:oxygen oxidoreductase activity;","K00157","AOX; aldehyde oxidase [EC:1.2.3.1]"]
["ENSRNOG00000000033",146,12.12189244,488,31.39325383,0.386130488,-1.372839623,{"v":2.50598E-28,"d":"2.51E-28"},{"v":1.25872e-27,"d":"1.26E-27"},"down","yes","Tmcc2","protein_coding","chr13:43794029-43831716:-","gi|760997468|ref|NP_001292057.1|",2836,0,"transmembrane and coiled-coil domains protein 2 [Rattus norvegicus]","gi|760997467|ref|NM_001305128.1|",3516,0,"Rattus norvegicus transmembrane and coiled-coil domain family 2 (Tmcc2), mRNA","Q80W04",1080,0,"Transmembrane and coiled-coil domains protein 2",".",".",".",".","pfam10267","Tmemb_cc2","Predicted transmembrane and coiled-coil 2 protein. This family of transmembrane coiled-coil containing proteins is conserved from worms to humans. Its function is unknown.","GO:0042982|amyloid precursor protein metabolic process;","GO:0005783|endoplasmic reticulum;GO:0012505|endomembrane system;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000048433",231,19.17915858,648,41.68612394,0.460084958,-1.120027805,{"v":2.17971E-27,"d":"2.18E-27"},{"v":1.06636e-26,"d":"1.07E-26"},"down","yes","Tshz2","protein_coding","chr3:158405423-158850128:+","gi|564302924|ref|XP_006224810.1|",4823,0,"PREDICTED: teashirt homolog 2 [Rattus norvegicus]","gi|672048349|ref|XM_006235659.2|",3765,0,"PREDICTED: Rattus norvegicus teashirt zinc finger homeobox 2 (Tshz2), mRNA","Q68FE9",1800,0,"Teashirt homolog 2",".",".",".",".","pfam03154","Atrophin-1","Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.",".",".",".",".","."]
["ENSRNOG00000067517",139,11.54070581,466,29.97798419,0.38497271,-1.377171916,{"v":3.01291e-27,"d":"3.01E-27"},{"v":1.46389e-26,"d":"1.46E-26"},"down","yes","ENSRNOG00000067517","protein_coding","chr17:2755682-2782723:+","gi|672080959|ref|XP_008769681.1|",2995,0,"PREDICTED: zinc finger protein 431-like isoform X5 [Rattus norvegicus]","gi|672029659|ref|XR_597997.1|",2840,0,"PREDICTED: Rattus norvegicus zinc finger protein 845-like (LOC100912742), misc_RNA","Q05481",753,0,"Zinc finger protein 91",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000056651",268,22.25114502,716,46.06059374,0.483084199,-1.049653431,{"v":3.03552e-27,"d":"3.04E-27"},{"v":1.47376e-26,"d":"1.47E-26"},"down","yes","ENSRNOG00000056651","protein_coding","chr1:84549831-84550664:-","gi|293355807|ref|XP_002728770.1|",222,{"v":7e-20,"d":"7.00E-20"},"PREDICTED: immortalization up-regulated protein-like [Rattus norvegicus]","gi|298886976|emb|FQ220383.1|",347,{"v":2E-180,"d":"2.00E-180"},"Rattus norvegicus TL0ADA43YB16 mRNA sequence",".",".",".",".",".",".",".",".","pfam07188","KSHV_K8","Kaposi's sarcoma-associated herpesvirus (KSHV) K8 protein. This family consists of Kaposi's sarcoma-associated herpesvirus (KSHV) K8 proteins. KSHV is a human Gammaherpesvirus related to Epstein-Barr virus (EBV) and herpesvirus saimiri. KSHV open reading frame K8 encodes a basic region-leucine zipper protein of 237 aa that homodimerises. K8 interacts and co-localizes with human pfam04855, a cellular chromatin-remodelling factor, both in vivo and in vitro. K8 is thought to function as a transcriptional activator under specific conditions and its transactivation activity requires its interaction with the cellular chromatin remodelling factor hSNF5.",".","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005829|cytosol;GO:0005886|plasma membrane;",".",".","."]
["ENSRNOG00000033087",66,5.479759595,305,19.62078365,0.279283422,-1.840198157,{"v":3.96567e-27,"d":"3.97E-27"},{"v":1.91952E-26,"d":"1.92E-26"},"down","yes","Cdh23","protein_coding","chr20:28240645-28622419:-","gi|17865345|ref|NP_446096.1|",17024,0,"cadherin-23 precursor [Rattus norvegicus]","gi|17865344|ref|NM_053644.1|",10780,0,"Rattus norvegicus cadherin-related 23 (Cdh23), mRNA","P58365",6546,0,"Cadherin-23",".",".",".",".","pfam00028","Cadherin","Cadherin domain.",".",".",".",".","."]
["ENSRNOG00000015816",206,17.10349207,595,38.27661072,0.446839251,-1.162172175,{"v":1.00147E-26,"d":"1.00E-26"},{"v":4.79661e-26,"d":"4.80E-26"},"down","yes","Bbs7","protein_coding","chr2:119434760-119474396:-","gi|58865932|ref|NP_001012180.1|",3555,0,"Bardet-Biedl syndrome 7 protein [Rattus norvegicus]","gi|58865931|ref|NM_001012180.1|",2116,0,"Rattus norvegicus Bardet-Biedl syndrome 7 (Bbs7), mRNA","Q8K2G4",1315,0,"Bardet-Biedl syndrome 7 protein homolog",".",".",".",".","pfam14783","BBS2_Mid","Ciliary BBSome complex subunit 2, middle region. The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialized for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction. BBS2 is one of the three Bardet-Biedl syndrome subunits that is required for leptin receptor signalling in the hypothalamus, and BBS2 and 4 are also required for the localisation of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia.","GO:0001654|eye development;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007224|smoothened signaling pathway;GO:0007420|brain development;GO:0007507|heart development;GO:0008104|protein localization;GO:0008150|biological_process;GO:0015031|protein transport;GO:0032436|positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0045444|fat cell differentiation;GO:0046907|intracellular transport;GO:0060173|limb development;GO:0060271|cilium assembly;GO:1903929|primary palate development;GO:1905515|non-motile cilium assembly;","GO:0001750|photoreceptor outer segment;GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005813|centrosome;GO:0005930|axoneme;GO:0016020|membrane;GO:0034464|BBSome;GO:0036064|ciliary basal body;GO:0043005|neuron projection;","GO:0003674|molecular_function;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;","K16749","BBS7; Bardet-Biedl syndrome 7 protein"]
["ENSRNOG00000017693",47,3.902253045,255,16.40426174,0.237880443,-2.071691429,{"v":1.44608e-26,"d":"1.45E-26"},{"v":6.90546e-26,"d":"6.91E-26"},"down","yes","Slc2a5","protein_coding","chr5:160583234-160611106:+","gi|1170105|sp|P43427.1|GTR5_RAT",2387,0,"RecName: Full=Solute carrier family 2, facilitated glucose transporter member 5; AltName: Full=Fructose transporter; AltName: Full=Glucose transporter type 5, small intestine; Short=GLUT-5","gi|13929043|ref|NM_031741.1|",2142,0,"Rattus norvegicus solute carrier family 2 member 5 (Slc2a5), mRNA","P43427",924,0,"Solute carrier family 2, facilitated glucose transporter member 5",".",".",".",".","pfam00083","Sugar_tr","Sugar (and other) transporter.","GO:0003044|regulation of systemic arterial blood pressure mediated by a chemical signal;GO:0009750|response to fructose;GO:0015755|fructose transmembrane transport;GO:0071332|cellular response to fructose stimulus;GO:1904659|glucose transmembrane transport;GO:1990539|fructose import across plasma membrane;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0016324|apical plasma membrane;GO:0042383|sarcolemma;","GO:0005353|fructose transmembrane transporter activity;GO:0005355|glucose transmembrane transporter activity;GO:0070061|fructose binding;","K08143","SLC2A5, GLUT5; MFS transporter, SP family, solute carrier family 2 (facilitated glucose/fructose transporter), member 5"]
["ENSRNOG00000031641",114,9.4650393,409,26.31114922,0.359734925,-1.474993863,{"v":1.45977e-26,"d":"1.46E-26"},{"v":6.96559e-26,"d":"6.97E-26"},"down","yes","Rpl35a","protein_coding","chr5:158537765-158544128:+","gi|148665412|gb|EDK97828.1|",596,{"v":6e-76,"d":"6.00E-76"},"mCG130125, isoform CRA_b, partial [Mus musculus]","gi|298891855|emb|FQ217774.1|",452,0,"Rattus norvegicus TL0ACA18YC08 mRNA sequence","P04646",227,{"v":3e-75,"d":"3.00E-75"},"60S ribosomal protein L35a","YOR234c",108,{"v":2e-29,"d":"2.00E-29"},"COG2451","pfam01247","Ribosomal_L35Ae","Ribosomal protein L35Ae.","GO:0006364|rRNA processing;GO:0008150|biological_process;GO:0042273|ribosomal large subunit biogenesis;","GO:0022625|cytosolic large ribosomal subunit;GO:0022626|cytosolic ribosome;","GO:0000049|tRNA binding;GO:0003735|structural constituent of ribosome;GO:0043021|ribonucleoprotein complex binding;","K02917","RP-L35Ae, RPL35A; large subunit ribosomal protein L35Ae"]
["ENSRNOG00000016364",249,20.67363847,674,43.35871534,0.476804682,-1.068529693,{"v":1.87172e-26,"d":"1.87E-26"},{"v":8.91802e-26,"d":"8.92E-26"},"down","yes","Gba2","protein_coding","chr5:57822389-57834072:-","gi|189217893|ref|NP_001013109.2|",4522,0,"non-lysosomal glucosylceramidase [Rattus norvegicus]","gi|189217892|ref|NM_001013091.2|",3022,0,"Rattus norvegicus glucosidase beta 2 (Gba2), mRNA","Q5M868",1716,0,"Non-lysosomal glucosylceramidase","alr2816",363,{"v":3e-109,"d":"3.00E-109"},"COG4354","pfam04685","DUF608","Protein of unknown function, DUF608. This family represents a conserved region with a pankaryotic distribution in a number of uncharacterized proteins.","GO:0005975|carbohydrate metabolic process;GO:0006680|glucosylceramide catabolic process;GO:0007417|central nervous system development;GO:0008203|cholesterol metabolic process;GO:0008206|bile acid metabolic process;GO:0016139|glycoside catabolic process;GO:0021954|central nervous system neuron development;GO:0030259|lipid glycosylation;GO:0030833|regulation of actin filament polymerization;GO:0031113|regulation of microtubule polymerization;GO:0097035|regulation of membrane lipid distribution;","GO:0000139|Golgi membrane;GO:0005789|endoplasmic reticulum membrane;GO:0005829|cytosol;GO:0016021|integral component of membrane;GO:0019898|extrinsic component of membrane;GO:0042406|extrinsic component of endoplasmic reticulum membrane;GO:0090498|extrinsic component of Golgi membrane;","GO:0004348|glucosylceramidase activity;GO:0008422|beta-glucosidase activity;GO:0046527|glucosyltransferase activity;GO:0050295|steryl-beta-glucosidase activity;","K17108","GBA2; non-lysosomal glucosylceramidase [EC:3.2.1.45]"]
["ENSRNOG00000046566",58,4.81554631,280,18.01252269,0.267344358,-1.903228866,{"v":3.96148e-26,"d":"3.96E-26"},{"v":1.86388e-25,"d":"1.86E-25"},"down","yes","Tub","protein_coding","chr1:162951931-163026812:+","gi|795247956|ref|XP_011809763.1|",2058,0,"PREDICTED: tubby protein homolog isoform X1 [Colobus angolensis palliatus]","gi|672037725|ref|XM_008759690.1|",1536,0,"PREDICTED: Rattus norvegicus tubby bipartite transcription factor (Tub), transcript variant X1, mRNA","P50607",747,0,"Tubby protein homolog",".",".",".",".","pfam01167","Tub","Tub family.","GO:0006910|phagocytosis, recognition;GO:0007605|sensory perception of sound;GO:0008277|regulation of G protein-coupled receptor signaling pathway;GO:0009725|response to hormone;GO:0042073|intraciliary transport;GO:0045494|photoreceptor cell maintenance;GO:0050766|positive regulation of phagocytosis;GO:0060041|retina development in camera-type eye;GO:0061512|protein localization to cilium;GO:0097500|receptor localization to non-motile cilium;GO:1903546|protein localization to photoreceptor outer segment;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005929|cilium;","GO:0001664|G protein-coupled receptor binding;GO:0003674|molecular_function;GO:0044877|protein-containing complex binding;GO:0120160|intraciliary transport particle A binding;","K19600","TUB, TULP; tubby and related proteins"]
["ENSRNOG00000013928",143,11.87281246,464,29.84932332,0.397758178,-1.330036502,{"v":8.17639e-26,"d":"8.18E-26"},{"v":3.78846e-25,"d":"3.79E-25"},"down","yes","Dsp","protein_coding","chr17:26623588-26671800:-","gi|109504778|ref|XP_225259.4|",13599,0,"PREDICTED: desmoplakin [Rattus norvegicus]","gi|672029930|ref|XM_001058477.5|",9624,0,"PREDICTED: Rattus norvegicus desmoplakin (Dsp), mRNA","E9Q557",5166,0,"Desmoplakin",".",".",".",".","pfam01576","Myosin_tail_1","Myosin tail. The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.","GO:0002934|desmosome organization;GO:0003223|ventricular compact myocardium morphogenesis;GO:0018149|peptide cross-linking;GO:0030216|keratinocyte differentiation;GO:0034332|adherens junction organization;GO:0042060|wound healing;GO:0043588|skin development;GO:0045104|intermediate filament cytoskeleton organization;GO:0045109|intermediate filament organization;GO:0086073|bundle of His cell-Purkinje myocyte adhesion involved in cell communication;GO:0086091|regulation of heart rate by cardiac conduction;GO:0090136|epithelial cell-cell adhesion;GO:0098609|cell-cell adhesion;GO:0098911|regulation of ventricular cardiac muscle cell action potential;","GO:0001533|cornified envelope;GO:0005737|cytoplasm;GO:0005882|intermediate filament;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0005916|fascia adherens;GO:0014704|intercalated disc;GO:0016020|membrane;GO:0016323|basolateral plasma membrane;GO:0030057|desmosome;","GO:0005080|protein kinase C binding;GO:0005198|structural molecule activity;GO:0050839|cell adhesion molecule binding;GO:0097110|scaffold protein binding;","K10381","DSP; desmoplakin"]
["ENSRNOG00000006698",130,10.79346587,437,28.11240149,0.38393966,-1.3810485,{"v":9.32242e-26,"d":"9.32E-26"},{"v":4.30387e-25,"d":"4.30E-25"},"down","yes","Rab33a","protein_coding","chrX:127694964-127706378:+","gi|332226374|ref|XP_003262364.1|",1362,0,"PREDICTED: ras-related protein Rab-33A [Nomascus leucogenys]","gi|157818280|ref|NM_001108257.1|",995,0,"Rattus norvegicus RAB33A, member RAS oncogene family (Rab33a), mRNA","Q14088",493,{"v":1E-175,"d":"1.00E-175"},"Ras-related protein Rab-33A",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0019882|antigen processing and presentation;GO:0032482|Rab protein signal transduction;","GO:0005768|endosome;GO:0005794|Golgi apparatus;","GO:0003924|GTPase activity;GO:0005525|GTP binding;","K07919","RAB33A; Ras-related protein Rab-33A"]
["ENSRNOG00000023664",44,3.653173063,242,15.56796604,0.234659624,-2.091358462,{"v":1.39155e-25,"d":"1.39E-25"},{"v":6.39205e-25,"d":"6.39E-25"},"down","yes","Lepr","protein_coding","chr5:116289823-116475908:+","gi|149044573|gb|EDL97832.1|",6168,0,"rCG53475, isoform CRA_b [Rattus norvegicus]","gi|6981149|ref|NM_012596.1|",3611,0,"Rattus norvegicus leptin receptor (Lepr), mRNA","Q62959",2375,0,"Leptin receptor",".",".",".",".","pfam06328","Lep_receptor_Ig","Ig-like C2-type domain. This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.","GO:0001525|angiogenesis;GO:0001542|ovulation from ovarian follicle;GO:0001666|response to hypoxia;GO:0001934|positive regulation of protein phosphorylation;GO:0005977|glycogen metabolic process;GO:0006091|generation of precursor metabolites and energy;GO:0006909|phagocytosis;GO:0007565|female pregnancy;GO:0007568|aging;GO:0007584|response to nutrient;GO:0008203|cholesterol metabolic process;GO:0008584|male gonad development;GO:0010507|negative regulation of autophagy;GO:0014009|glial cell proliferation;GO:0019221|cytokine-mediated signaling pathway;GO:0019953|sexual reproduction;GO:0030217|T cell differentiation;GO:0033210|leptin-mediated signaling pathway;GO:0033993|response to lipid;GO:0035094|response to nicotine;GO:0035774|positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0042060|wound healing;GO:0042593|glucose homeostasis;GO:0042755|eating behavior;GO:0043410|positive regulation of MAPK cascade;GO:0043627|response to estrogen;GO:0044321|response to leptin;GO:0045721|negative regulation of gluconeogenesis;GO:0046850|regulation of bone remodeling;GO:0051049|regulation of transport;GO:0051346|negative regulation of hydrolase activity;GO:0060259|regulation of feeding behavior;GO:0071310|cellular response to organic substance;GO:0071548|response to dexamethasone;GO:0097009|energy homeostasis;GO:0098868|bone growth;GO:0120162|positive regulation of cold-induced thermogenesis;GO:1903999|negative regulation of eating behavior;GO:1904060|negative regulation of locomotor rhythm;","GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016328|lateral plasma membrane;GO:0043235|receptor complex;","GO:0004896|cytokine receptor activity;GO:0016500|protein-hormone receptor activity;GO:0017046|peptide hormone binding;GO:0019955|cytokine binding;GO:0038021|leptin receptor activity;GO:0042802|identical protein binding;","K05062","LEPR, CD295; leptin receptor"]
["ENSRNOG00000011775",24,1.992639853,186,11.9654615,0.166532637,-2.586123154,{"v":2.40539e-25,"d":"2.41E-25"},{"v":1.09624e-24,"d":"1.10E-24"},"down","yes","Mfap3l","protein_coding","chr16:29415849-29430863:-","gi|148696689|gb|EDL28636.1|",2166,0,"microfibrillar-associated protein 3-like, isoform CRA_b, partial [Mus musculus]","gi|58865673|ref|NM_001012049.1|",1925,0,"Rattus norvegicus microfibrillar-associated protein 3-like (Mfap3l), mRNA","Q6AYP2",801,0,"Microfibrillar-associated protein 3-like",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.",".","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030054|cell junction;",".","K25408","MFAP3L; microfibrillar-associated protein 3-like"]
["ENSRNOG00000028910",66,5.479759595,294,18.91314883,0.289732802,-1.787205069,{"v":3.03902e-25,"d":"3.04E-25"},{"v":1.37912e-24,"d":"1.38E-24"},"down","yes","Ccdc9b","protein_coding","chr3:105739174-105744697:-","gi|155029554|ref|NP_001001982.2|",2200,0,"uncharacterized protein C15orf52 homolog [Mus musculus]","gi|564302149|ref|XR_085782.2|",1766,0,"PREDICTED: Rattus norvegicus similar to hypothetical protein (RGD1565536), misc_RNA",".",".",".",".",".",".",".",".","pfam15266","DUF4594","Domain of unknown function (DUF4594). This protein family is a domain of unknown function. The protein family is found in eukaryotes, and is typically between 170 and 183 amino acids in length.In humans, the gene encoding this protein lies in the position, chromosome 15 open reading frame 52.",".",".",".",".","."]
["ENSRNOG00000027392",108,8.966879337,386,24.83154914,0.361108334,-1.469496379,{"v":4.97183e-25,"d":"4.97E-25"},{"v":2.24034e-24,"d":"2.24E-24"},"down","yes","Ccdc187","protein_coding","chr3:9070185-9126946:-","gi|755497662|ref|XP_011237420.1|",7423,0,"PREDICTED: uncharacterized protein LOC329366 isoform X3 [Mus musculus]","gi|755497667|ref|XM_011239121.1|",4170,0,"PREDICTED: Mus musculus RIKEN cDNA 4932418E24 gene (4932418E24Rik), transcript variant X6, mRNA","Q8C5V8",1281,0,"Coiled-coil domain-containing protein 187",".",".",".",".","pfam14817","HAUS5","HAUS augmin-like complex subunit 5. This family includes HAUS augmin-like complex subunit 5. The HAUS augmin-like complex contributes to mitotic spindle assembly, maintenance of chromosome integrity and completion of cytokinesis.","GO:0034453|microtubule anchoring;","GO:0005813|centrosome;","GO:0008017|microtubule binding;",".","."]
["ENSRNOG00000006096",22,1.826586532,176,11.32215712,0.161328492,-2.631926844,{"v":1.661e-24,"d":"1.66E-24"},{"v":7.36009e-24,"d":"7.36E-24"},"down","yes","Slc26a7","protein_coding","chr5:27887042-28021658:-","gi|568926289|ref|XP_006537785.1|",3239,0,"PREDICTED: anion exchange transporter isoform X1 [Mus musculus]","gi|755506183|ref|XM_006537723.2|",2033,0,"PREDICTED: Mus musculus solute carrier family 26, member 7 (Slc26a7), transcript variant X2, mRNA","Q8R2Z3",1165,0,"Anion exchange transporter","lin0529",113,{"v":3e-25,"d":"3.00E-25"},"COG0659","pfam00916","Sulfate_transp","Sulfate transporter family. Mutations in human SLC26A2 lead to several human diseases.","GO:0001696|gastric acid secretion;GO:0006820|anion transport;GO:0006821|chloride transport;GO:0008272|sulfate transport;GO:0015701|bicarbonate transport;GO:0019532|oxalate transport;GO:1902358|sulfate transmembrane transport;GO:1902476|chloride transmembrane transport;","GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005887|integral component of plasma membrane;GO:0016323|basolateral plasma membrane;","GO:0005253|anion channel activity;GO:0005254|chloride channel activity;GO:0008271|secondary active sulfate transmembrane transporter activity;GO:0015106|bicarbonate transmembrane transporter activity;GO:0015108|chloride transmembrane transporter activity;GO:0015116|sulfate transmembrane transporter activity;GO:0015301|anion:anion antiporter activity;GO:0019531|oxalate transmembrane transporter activity;","K13962","SLC26A7, SUT2; solute carrier family 26 (anion exchange transporter), member 7"]
["ENSRNOG00000010731",28,2.324746495,192,12.35144413,0.188216574,-2.409534422,{"v":3.19243e-24,"d":"3.19E-24"},{"v":1.39813E-23,"d":"1.40E-23"},"down","yes","Gpm6a","protein_coding","chr16:36641284-36973475:-","gi|390460231|ref|XP_002745248.2|",1379,{"v":2E-179,"d":"2.00E-179"},"PREDICTED: neuronal membrane glycoprotein M6-a isoform X1 [Callithrix jacchus]","gi|672080110|ref|XM_006253093.2|",2737,0,"PREDICTED: Rattus norvegicus glycoprotein m6a (Gpm6a), transcript variant X1, mRNA","Q812E9",509,{"v":5e-172,"d":"5.00E-172"},"Neuronal membrane glycoprotein M6-a",".",".",".",".","pfam01275","Myelin_PLP","Myelin proteolipid protein (PLP or lipophilin).","GO:0001764|neuron migration;GO:0003407|neural retina development;GO:0007416|synapse assembly;GO:0009617|response to bacterium;GO:0031175|neuron projection development;GO:0048812|neuron projection morphogenesis;GO:0048863|stem cell differentiation;GO:0050807|regulation of synapse organization;GO:0051491|positive regulation of filopodium assembly;GO:0070588|calcium ion transmembrane transport;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030175|filopodium;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043197|dendritic spine;GO:0044295|axonal growth cone;GO:0098978|glutamatergic synapse;GO:0099059|integral component of presynaptic active zone membrane;","GO:0005262|calcium channel activity;GO:0005515|protein binding;",".","."]
["ENSRNOG00000017424",58,4.81554631,269,17.30488787,0.278276655,-1.845408211,{"v":3.31686e-24,"d":"3.32E-24"},{"v":1.45064e-23,"d":"1.45E-23"},"down","yes","Chrna2","protein_coding","chr15:40342317-40358601:+","gi|672078229|ref|XP_008768957.1|",2690,0,"PREDICTED: neuronal acetylcholine receptor subunit alpha-2 isoform X1 [Rattus norvegicus]","gi|19173791|ref|NM_133420.1|",1931,0,"Rattus norvegicus cholinergic receptor nicotinic alpha 2 subunit (Chrna2), mRNA","P12389",990,0,"Neuronal acetylcholine receptor subunit alpha-2",".",".",".",".","pfam02931","Neur_chan_LBD","Neurotransmitter-gated ion-channel ligand binding domain. This family is the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.","GO:0007165|signal transduction;GO:0007268|chemical synaptic transmission;GO:0007271|synaptic transmission, cholinergic;GO:0034220|ion transmembrane transport;GO:0035094|response to nicotine;GO:0042391|regulation of membrane potential;GO:0050877|nervous system process;GO:0060079|excitatory postsynaptic potential;","GO:0005887|integral component of plasma membrane;GO:0005892|acetylcholine-gated channel complex;GO:0016020|membrane;GO:0032991|protein-containing complex;GO:0043005|neuron projection;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0071944|cell periphery;","GO:0015464|acetylcholine receptor activity;GO:0022848|acetylcholine-gated cation-selective channel activity;GO:0030594|neurotransmitter receptor activity;","K04804","CHRNA2; nicotinic acetylcholine receptor alpha-2"]
["ENSRNOG00000070388",162,13.45031901,490,31.52191471,0.426697399,-1.22871478,{"v":3.32177E-24,"d":"3.32E-24"},{"v":1.45179e-23,"d":"1.45E-23"},"down","yes","ENSRNOG00000070388","lncRNA","chr4:59815882-59990223:+","gi|148681769|gb|EDL13716.1|",152,6e-08,"mCG4750, isoform CRA_b [Mus musculus]","gi|66793662|gb|AC158658.4|",1852,0,"Mus musculus 6 BAC RP23-400L4 (Roswell Park Cancer Institute (C57BL/6J Female) Mouse BAC Library) complete sequence",".",".",".",".",".",".",".",".","pfam08907","DUF1853","Domain of unknown function (DUF1853). This family of proteins are functionally uncharacterized.",".",".",".",".","."]
["ENSRNOG00000016196",177,14.69571891,519,33.38749742,0.440156347,-1.183912022,{"v":3.54683e-24,"d":"3.55E-24"},{"v":1.5491e-23,"d":"1.55E-23"},"down","yes","Dlgap1","protein_coding","chr9:110167448-110726817:+","gi|748585196|ref|NP_075235.3|",4701,0,"disks large-associated protein 1 isoform 1 [Rattus norvegicus]","gi|748585195|ref|NM_022946.3|",6417,0,"Rattus norvegicus discs large homolog associated protein 1 (Dlgap1), transcript variant 1, mRNA","P97836",1808,0,"Disks large-associated protein 1",".",".",".",".","pfam03359","GKAP","Guanylate-kinase-associated protein (GKAP) protein.","GO:0007268|chemical synaptic transmission;GO:0035418|protein localization to synapse;GO:0061136|regulation of proteasomal protein catabolic process;GO:0070842|aggresome assembly;GO:0098962|regulation of postsynaptic neurotransmitter receptor activity;GO:0099562|maintenance of postsynaptic density structure;","GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0098978|glutamatergic synapse;GO:0099092|postsynaptic density, intracellular component;GO:0099572|postsynaptic specialization;","GO:0005515|protein binding;GO:0019904|protein domain specific binding;GO:0044877|protein-containing complex binding;GO:0060090|molecular adaptor activity;GO:0098919|structural constituent of postsynaptic density;","K15008","DLGAP1, GKAP; discs, large-associated protein 1"]
["ENSRNOG00000013123",56,4.649492989,264,16.98323568,0.273769562,-1.868966041,{"v":3.59642E-24,"d":"3.60E-24"},{"v":1.56862E-23,"d":"1.57E-23"},"down","yes","Scube2","protein_coding","chr1:163832015-163899393:-","gi|392337862|ref|XP_003753378.1|",5085,0,"PREDICTED: signal peptide, CUB and EGF-like domain-containing protein 2 isoform X1 [Rattus norvegicus]","gi|672014129|ref|XM_003753330.3|",3506,0,"PREDICTED: Rattus norvegicus signal peptide, CUB domain, EGF-like 2 (Scube2), transcript variant X1, mRNA","Q9JJS0",1737,0,"Signal peptide, CUB and EGF-like domain-containing protein 2",".",".",".",".","pfam00431","CUB","CUB domain.","GO:0003413|chondrocyte differentiation involved in endochondral bone morphogenesis;GO:0007165|signal transduction;GO:0045669|positive regulation of osteoblast differentiation;GO:0045778|positive regulation of ossification;GO:0045880|positive regulation of smoothened signaling pathway;GO:1902732|positive regulation of chondrocyte proliferation;","GO:0005615|extracellular space;GO:0009986|cell surface;","GO:0005509|calcium ion binding;GO:0097108|hedgehog family protein binding;","K24706","SCUBE2; signal peptide, CUB and EGF-like domain-containing protein 2"]
["ENSRNOG00000018477",178,14.77874557,520,33.45182786,0.44179187,-1.178561226,{"v":4.66255e-24,"d":"4.66E-24"},{"v":2.02533E-23,"d":"2.03E-23"},"down","yes","Otud4","protein_coding","chr19:28236713-28279815:-","gi|300794663|ref|NP_001178629.1|",5178,0,"OTU domain-containing protein 4 [Rattus norvegicus]","gi|300794662|ref|NM_001191700.1|",3193,0,"Rattus norvegicus OTU deubiquitinase 4 (Otud4), mRNA","B2RRE7",1920,0,"OTU domain-containing protein 4",".",".",".",".","pfam02338","OTU","OTU-like cysteine protease. This family is comprised of a group of predicted cysteine proteases, homologous to the Ovarian tumor (OTU) gene in Drosophila. Members include proteins from eukaryotes, viruses and pathogenic bacterium. The conserved cysteine and histidine, and possibly the aspartate, represent the catalytic residues in this putative group of proteases.","GO:0016579|protein deubiquitination;GO:0034122|negative regulation of toll-like receptor signaling pathway;GO:0070536|protein K63-linked deubiquitination;GO:0071108|protein K48-linked deubiquitination;GO:1901537|positive regulation of DNA demethylation;GO:1903093|regulation of protein K48-linked deubiquitination;GO:2000660|negative regulation of interleukin-1-mediated signaling pathway;","GO:0005829|cytosol;","GO:0004843|thiol-dependent ubiquitin-specific protease activity;GO:0060090|molecular adaptor activity;GO:0061578|Lys63-specific deubiquitinase activity;","K13718","OTUD4; OTU domain-containing protein 4 [EC:3.4.19.12]"]
["ENSRNOG00000014504",255,21.17179843,663,42.65108052,0.496395359,-1.010438467,{"v":6.5495e-24,"d":"6.55E-24"},{"v":2.82579e-23,"d":"2.83E-23"},"down","yes","Il1r1","protein_coding","chr9:42504735-42579937:+","gi|148747433|ref|NP_037255.3|",3033,0,"interleukin-1 receptor type 1 [Rattus norvegicus]","gi|672064797|ref|XM_006244748.2|",3886,0,"PREDICTED: Rattus norvegicus interleukin 1 receptor, type I (Il1r1), transcript variant X3, mRNA","Q02955",1164,0,"Interleukin-1 receptor type 1",".",".",".",".","pfam01582","TIR","TIR domain. The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.","GO:0006954|inflammatory response;GO:0009314|response to radiation;GO:0010286|heat acclimation;GO:0019221|cytokine-mediated signaling pathway;GO:0030728|ovulation;GO:0032729|positive regulation of interferon-gamma production;GO:0050727|regulation of inflammatory response;GO:0070498|interleukin-1-mediated signaling pathway;GO:0070555|response to interleukin-1;GO:0070849|response to epidermal growth factor;GO:0071333|cellular response to glucose stimulus;GO:0071559|response to transforming growth factor beta;GO:0071731|response to nitric oxide;GO:1990834|response to odorant;GO:2000391|positive regulation of neutrophil extravasation;GO:2000556|positive regulation of T-helper 1 cell cytokine production;GO:2000661|positive regulation of interleukin-1-mediated signaling pathway;GO:2001224|positive regulation of neuron migration;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0032991|protein-containing complex;","GO:0002020|protease binding;GO:0003953|NAD+ nucleosidase activity;GO:0004908|interleukin-1 receptor activity;GO:0004909|interleukin-1, type I, activating receptor activity;GO:0005161|platelet-derived growth factor receptor binding;GO:0005515|protein binding;GO:0019966|interleukin-1 binding;GO:0035255|ionotropic glutamate receptor binding;GO:0050135|NAD(P)+ nucleosidase activity;GO:0061809|NAD+ nucleotidase, cyclic ADP-ribose generating;","K04386","IL1R1, CD121a; interleukin 1 receptor type I"]
["ENSRNOG00000062470",129,10.71043921,420,27.01878404,0.396407151,-1.334945106,{"v":1.20735E-23,"d":"1.21E-23"},{"v":5.16728e-23,"d":"5.17E-23"},"down","yes","ENSRNOG00000062470","lncRNA","chr18:76385516-76386517:-",".",".",".",".","gi|672083299|ref|XM_008772100.1|",1002,0,"PREDICTED: Rattus norvegicus zinc finger protein 516 (Zfp516), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam07666","MpPF26","M penetrans paralogue family 26. These proteins include those ascribed to M penetrans paralogue family 26 in.",".",".",".",".","."]
["ENSRNOG00000058645",178,14.77874557,516,33.1945061,0.445216613,-1.167420668,{"v":1.49863E-23,"d":"1.50E-23"},{"v":6.37978E-23,"d":"6.38E-23"},"down","yes","Tnc","protein_coding","chr5:77375851-77460624:-","gi|672052772|ref|XP_008761976.1|",11592,0,"PREDICTED: tenascin isoform X2 [Rattus norvegicus]","gi|672052771|ref|XM_008763754.1|",7527,0,"PREDICTED: Rattus norvegicus tenascin C (Tnc), transcript variant X1, mRNA","P24821",3703,0,"Tenascin",".",".",".",".","pfam00147","Fibrinogen_C","Fibrinogen beta and gamma chains, C-terminal globular domain.","GO:0007155|cell adhesion;GO:0007162|negative regulation of cell adhesion;GO:0007528|neuromuscular junction development;GO:0008284|positive regulation of cell proliferation;GO:0009611|response to wounding;GO:0009612|response to mechanical stimulus;GO:0010628|positive regulation of gene expression;GO:0014012|peripheral nervous system axon regeneration;GO:0031175|neuron projection development;GO:0042060|wound healing;GO:0042475|odontogenesis of dentin-containing tooth;GO:0045471|response to ethanol;GO:0060447|bud outgrowth involved in lung branching;GO:0060739|mesenchymal-epithelial cell signaling involved in prostate gland development;GO:0060740|prostate gland epithelium morphogenesis;GO:0071300|cellular response to retinoic acid;GO:0071305|cellular response to vitamin D;GO:0071774|response to fibroblast growth factor;GO:0071799|cellular response to prostaglandin D stimulus;","GO:0005576|extracellular region;GO:0005604|basement membrane;GO:0005614|interstitial matrix;GO:0031012|extracellular matrix;GO:0098966|perisynaptic extracellular matrix;","GO:0003674|molecular_function;GO:0045545|syndecan binding;","K06252","TN; tenascin"]
["ENSRNOG00000029986",113,9.382012639,385,24.7672187,0.378807679,-1.400462517,{"v":2.43116e-23,"d":"2.43E-23"},{"v":1.0254e-22,"d":"1.03E-22"},"down","yes","Insr","protein_coding","chr12:1197100-1330883:-","gi|298231200|ref|NP_058767.2|",7161,0,"insulin receptor preproprotein [Rattus norvegicus]","gi|298231199|ref|NM_017071.2|",5390,0,"Rattus norvegicus insulin receptor (Insr), mRNA","P15127",2749,0,"Insulin receptor","YAR019c",95.5,{"v":9e-19,"d":"9.00E-19"},"COG0515","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0000380|alternative mRNA splicing, via spliceosome;GO:0001666|response to hypoxia;GO:0001889|liver development;GO:0001933|negative regulation of protein phosphorylation;GO:0001934|positive regulation of protein phosphorylation;GO:0002092|positive regulation of receptor internalization;GO:0003007|heart morphogenesis;GO:0006111|regulation of gluconeogenesis;GO:0006355|regulation of transcription, DNA-templated;GO:0006468|protein phosphorylation;GO:0006898|receptor-mediated endocytosis;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007275|multicellular organism development;GO:0008284|positive regulation of cell proliferation;GO:0008286|insulin receptor signaling pathway;GO:0008544|epidermis development;GO:0008584|male gonad development;GO:0009725|response to hormone;GO:0009749|response to glucose;GO:0009887|animal organ morphogenesis;GO:0010033|response to organic substance;GO:0010042|response to manganese ion;GO:0010310|regulation of hydrogen peroxide metabolic process;GO:0010560|positive regulation of glycoprotein biosynthetic process;GO:0010629|negative regulation of gene expression;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0014823|response to activity;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0021549|cerebellum development;GO:0021766|hippocampus development;GO:0030238|male sex determination;GO:0030325|adrenal gland development;GO:0030335|positive regulation of cell migration;GO:0031017|exocrine pancreas development;GO:0031667|response to nutrient levels;GO:0032094|response to food;GO:0032147|activation of protein kinase activity;GO:0032148|activation of protein kinase B activity;GO:0032355|response to estradiol;GO:0032410|negative regulation of transporter activity;GO:0032868|response to insulin;GO:0032869|cellular response to insulin stimulus;GO:0033280|response to vitamin D;GO:0033574|response to testosterone;GO:0033674|positive regulation of kinase activity;GO:0034612|response to tumor necrosis factor;GO:0038083|peptidyl-tyrosine autophosphorylation;GO:0042327|positive regulation of phosphorylation;GO:0042593|glucose homeostasis;GO:0042594|response to starvation;GO:0043243|positive regulation of protein complex disassembly;GO:0043406|positive regulation of MAP kinase activity;GO:0043410|positive regulation of MAPK cascade;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0045444|fat cell differentiation;GO:0045471|response to ethanol;GO:0045719|negative regulation of glycogen biosynthetic process;GO:0045725|positive regulation of glycogen biosynthetic process;GO:0045821|positive regulation of glycolytic process;GO:0045840|positive regulation of mitotic nuclear division;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045995|regulation of embryonic development;GO:0046326|positive regulation of glucose import;GO:0046777|protein autophosphorylation;GO:0048639|positive regulation of developmental growth;GO:0051384|response to glucocorticoid;GO:0051446|positive regulation of meiotic cell cycle;GO:0051897|positive regulation of protein kinase B signaling;GO:0060267|positive regulation of respiratory burst;GO:0071363|cellular response to growth factor stimulus;GO:0097062|dendritic spine maintenance;GO:0097242|amyloid-beta clearance;GO:0097421|liver regeneration;GO:1902438|response to vanadate(3-);GO:1904638|response to resveratrol;GO:1990402|embryonic liver development;GO:1990535|neuron projection maintenance;GO:2000194|regulation of female gonad development;GO:2000252|negative regulation of feeding behavior;","GO:0005634|nucleus;GO:0005635|nuclear envelope;GO:0005764|lysosome;GO:0005768|endosome;GO:0005770|late endosome;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005899|insulin receptor complex;GO:0005901|caveola;GO:0009897|external side of plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0031410|cytoplasmic vesicle;GO:0031981|nuclear lumen;GO:0032590|dendrite membrane;GO:0032809|neuronal cell body membrane;GO:0043025|neuronal cell body;GO:0043231|intracellular membrane-bounded organelle;GO:0043235|receptor complex;GO:0044297|cell body;GO:0045202|synapse;GO:0060417|yolk;","GO:0001540|amyloid-beta binding;GO:0004672|protein kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0005009|insulin-activated receptor activity;GO:0005159|insulin-like growth factor receptor binding;GO:0005198|structural molecule activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0005525|GTP binding;GO:0019901|protein kinase binding;GO:0019903|protein phosphatase binding;GO:0019904|protein domain specific binding;GO:0031405|lipoic acid binding;GO:0031994|insulin-like growth factor I binding;GO:0031995|insulin-like growth factor II binding;GO:0038024|cargo receptor activity;GO:0042802|identical protein binding;GO:0043423|3-phosphoinositide-dependent protein kinase binding;GO:0043548|phosphatidylinositol 3-kinase binding;GO:0043559|insulin binding;GO:0043560|insulin receptor substrate binding;GO:0044877|protein-containing complex binding;GO:0051425|PTB domain binding;","K04527","INSR, CD220; insulin receptor [EC:2.7.10.1]"]
["ENSRNOG00000069152",113,9.382012639,385,24.7672187,0.378807679,-1.400462517,{"v":2.43116e-23,"d":"2.43E-23"},{"v":1.0254e-22,"d":"1.03E-22"},"down","yes","ENSRNOG00000069152","lncRNA","chr12:9352241-9353979:-","gi|149038339|gb|EDL92699.1|",194,{"v":5E-15,"d":"5.00E-15"},"rCG63222 [Rattus norvegicus]","gi|672026501|ref|XR_339408.2|",537,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102554162 (LOC102554162), ncRNA",".",".",".",".",".",".",".",".","pfam00509","Hemagglutinin","Haemagglutinin. Hemagglutinin from influenza virus causes membrane fusion of the viral membrane with the host membrane. Fusion occurs after the host cell internalises the virus by endocytosis. The drop of pH causes release of a hydrophobic fusion peptide and a large conformational change leading to membrane fusion.",".",".",".",".","."]
["ENSRNOG00000025781",21,1.743559871,167,10.74318318,0.162294531,-2.623313714,{"v":2.93869e-23,"d":"2.94E-23"},{"v":1.23539E-22,"d":"1.24E-22"},"down","yes","Sec31b","protein_coding","chr1:243378456-243404557:-","gi|564333979|ref|XP_006231546.1|",5520,0,"PREDICTED: protein transport protein Sec31B isoform X1 [Rattus norvegicus]","gi|672040430|ref|XM_006231484.2|",4103,0,"PREDICTED: Rattus norvegicus SEC31 homolog B (S. cerevisiae) (Sec31b), transcript variant X1, mRNA","Q3TZ89",1857,0,"Protein transport protein Sec31B",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.","GO:0006886|intracellular protein transport;GO:0007029|endoplasmic reticulum organization;GO:0090110|cargo loading into COPII-coated vesicle;","GO:0005789|endoplasmic reticulum membrane;GO:0030120|vesicle coat;GO:0030127|COPII vesicle coat;GO:0070971|endoplasmic reticulum exit site;","GO:0005198|structural molecule activity;","K14005","SEC31; protein transport protein SEC31"]
["ENSRNOG00000069664",9,0.747239945,128,8.234296088,0.090747277,-3.462001842,{"v":3.21668e-23,"d":"3.22E-23"},{"v":1.34871e-22,"d":"1.35E-22"},"down","yes","ENSRNOG00000069664","protein_coding","chr11:4144721-4148339:-","gi|70778812|ref|NP_780421.2|",411,{"v":2E-45,"d":"2.00E-45"},"transmembrane protein 65 [Mus musculus]","gi|14389324|gb|AC087775.2|",371,0,"Rattus norvegicus strain Brown Norway clone RP31-464J4, complete sequence","Q4VAE3",162,{"v":7e-47,"d":"7.00E-47"},"Transmembrane protein 65",".",".",".",".","pfam10507","DUF2453","Protein of unknown function (DUF2453). Some members of this family are purported to contain GAF domains but this could not be confirmed. The function is not known. It is likely to be a transmembrane protein.",".",".",".",".","."]
["ENSRNOG00000066099",37,3.071986439,211,13.57372246,0.226318642,-2.143572667,{"v":3.54961e-23,"d":"3.55E-23"},{"v":1.48441e-22,"d":"1.48E-22"},"down","yes","ENSRNOG00000066099","lncRNA","chr1:53816738-53818753:-","gi|149028494|gb|EDL83879.1|",251,{"v":1e-23,"d":"1.00E-23"},"rCG22859 [Rattus norvegicus]","gi|31455626|gb|AC111648.6|",513,0,"Rattus norvegicus 2 BAC CH230-103N18 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam02093","Gag_p30","Gag P30 core shell protein. According to Swiss-Prot annotation this protein is the viral core shell protein. P30 is essential for viral assembly.",".",".",".",".","."]
["ENSRNOG00000014293",234,19.42823856,616,39.62754992,0.490271001,-1.028348665,{"v":6.14751E-23,"d":"6.15E-23"},{"v":2.5508e-22,"d":"2.55E-22"},"down","yes","Nkd1","protein_coding","chr19:18476344-18549380:-","gi|405778354|ref|NP_001258310.1|",2311,0,"protein naked cuticle homolog 1 [Rattus norvegicus]","gi|405778353|ref|NM_001271381.1|",2557,0,"Rattus norvegicus naked cuticle homolog 1 (Drosophila) (Nkd1), mRNA","Q99MH6",865,0,"Protein naked cuticle homolog 1",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.","GO:0016055|Wnt signaling pathway;GO:0030178|negative regulation of Wnt signaling pathway;GO:0045732|positive regulation of protein catabolic process;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:1901231|positive regulation of non-canonical Wnt signaling pathway via JNK cascade;GO:1901233|negative regulation of convergent extension involved in axis elongation;GO:2000096|positive regulation of Wnt signaling pathway, planar cell polarity pathway;","GO:0000159|protein phosphatase type 2A complex;GO:0005737|cytoplasm;GO:0005886|plasma membrane;","GO:0005509|calcium ion binding;GO:0030165|PDZ domain binding;","K03213","NKD; naked cuticle"]
["ENSRNOG00000008492",72,5.977919558,292,18.78448795,0.318237025,-1.651826401,{"v":1.26101e-22,"d":"1.26E-22"},{"v":5.18522e-22,"d":"5.19E-22"},"down","yes","Cfap45","protein_coding","chr13:84981728-85012878:+","gi|851330416|ref|NP_001020053.2|",2145,0,"coiled-coil domain-containing protein 19, mitochondrial [Rattus norvegicus]","gi|851330415|ref|NM_001024882.2|",1766,0,"Rattus norvegicus cilia and flagella associated protein 45 (Cfap45), mRNA","Q9UL16",719,0,"Cilia- and flagella-associated protein 45",".",".",".",".","pfam13868","Trichoplein","tumor suppressor, Mitostatin. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs).","GO:0030317|flagellated sperm motility;GO:0060287|epithelial cilium movement involved in determination of left/right asymmetry;GO:0060296|regulation of cilium beat frequency involved in ciliary motility;GO:0061966|establishment of left/right asymmetry;GO:0090660|cerebrospinal fluid circulation;","GO:0005576|extracellular region;GO:0005654|nucleoplasm;GO:0005930|axoneme;GO:0097728|9+0 motile cilium;GO:0097729|9+2 motile cilium;","GO:0016208|AMP binding;","K25551","CFAP45; cilia- and flagella-associated protein 45"]
["ENSRNOG00000022772",213,17.68467869,574,36.92567152,0.478926394,-1.06212415,{"v":1.45463E-22,"d":"1.45E-22"},{"v":5.9546E-22,"d":"5.95E-22"},"down","yes","Prickle1","protein_coding","chr7:124639142-124658113:-","gi|209915609|ref|NP_955428.1|",4021,0,"prickle-like protein 1 [Rattus norvegicus]","gi|209915608|ref|NM_199396.1|",4485,0,"Rattus norvegicus prickle planar cell polarity protein 1 (Prickle1), mRNA","Q71QF9",1550,0,"Prickle-like protein 1",".",".",".",".","pfam06297","PET","PET Domain. This domain is suggested to be involved in protein-protein interactions. The family is found in conjunction with pfam00412.","GO:0001843|neural tube closure;GO:0006606|protein import into nucleus;GO:0031398|positive regulation of protein ubiquitination;GO:0032436|positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0035904|aorta development;GO:0045892|negative regulation of transcription, DNA-templated;GO:0060976|coronary vasculature development;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:2000691|negative regulation of cardiac muscle cell myoblast differentiation;","GO:0005634|nucleus;GO:0005829|cytosol;GO:0031965|nuclear membrane;","GO:0005515|protein binding;GO:0008270|zinc ion binding;","K04511","PRICKLE; prickle"]
["ENSRNOG00000063592",94,7.804506089,338,21.74368811,0.358932029,-1.478217428,{"v":2.67081e-22,"d":"2.67E-22"},{"v":1.08428e-21,"d":"1.08E-21"},"down","yes","Lyve1","pseudogene","chr1:164962872-164976309:-","gi|61889129|ref|NP_058961.4|",1518,0,"3 beta-hydroxysteroid dehydrogenase/Delta 5-->gi|157820637|ref|NP_001099756.1| lymphatic vessel endothelial hyaluronic acid receptor 1 [Rattus norvegicus]","gi|157820636|ref|NM_001106286.1|",2982,0,"Rattus norvegicus lymphatic vessel endothelial hyaluronan receptor 1 (Lyve1), mRNA","Q8BHC0",449,{"v":1e-147,"d":"1.00E-147"},"Lymphatic vessel endothelial hyaluronic acid receptor 1",".",".",".",".","pfam00193","Xlink","Extracellular link domain.",".",".",".",".","."]
["ENSRNOG00000001701",93,7.721479429,335,21.55069679,0.358293725,-1.480785318,{"v":3.60849e-22,"d":"3.61E-22"},{"v":1.45663E-21,"d":"1.46E-21"},"down","yes","Cbr3","protein_coding","chr11:33008615-33016875:+","gi|157819653|ref|NP_001100580.1|",1471,0,"carbonyl reductase [NADPH] 3 [Rattus norvegicus]","gi|157819652|ref|NM_001107110.1|",1175,0,"Rattus norvegicus carbonyl reductase 3 (Cbr3), mRNA","Q8K354",560,0,"Carbonyl reductase [NADPH] 3","all0352",145,{"v":2e-39,"d":"2.00E-39"},"COG1028","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.","GO:0042376|phylloquinone catabolic process;GO:0050890|cognition;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0000253|3-keto sterol reductase activity;GO:0004090|carbonyl reductase (NADPH) activity;GO:0016491|oxidoreductase activity;GO:0070402|NADPH binding;","K00084","CBR3; carbonyl reductase 3 [EC:1.1.1.184]"]
["ENSRNOG00000015088",123,10.21227924,397,25.53918396,0.399867093,-1.322407536,{"v":3.88103e-22,"d":"3.88E-22"},{"v":1.56369e-21,"d":"1.56E-21"},"down","yes","Prune2","protein_coding","chr1:214352955-214622650:+","gi|672014895|ref|XP_008773046.1|",13330,0,"PREDICTED: protein prune homolog 2 isoform X1 [Rattus norvegicus]","gi|672039938|ref|XM_006231152.2|",8315,0,"PREDICTED: Rattus norvegicus prune homolog 2 (Drosophila) (Prune2), transcript variant X2, mRNA","Q52KR3",4795,0,"Protein prune homolog 2",".",".",".",".","pfam12496","BNIP2","Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2. This domain family is found in eukaryotes, and is typically between 119 and 133 amino acids in length. There is a conserved HGGY sequence motif. This family is Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2. It interacts with pro- and anti- apoptotic molecules in the cell.",".",".",".",".","."]
["ENSRNOG00000003221",21,1.743559871,161,10.35720055,0.168342774,-2.570526299,{"v":5.10057e-22,"d":"5.10E-22"},{"v":2.05117e-21,"d":"2.05E-21"},"down","yes","Myoc","protein_coding","chr13:74976730-74987127:+","gi|149058242|gb|EDM09399.1|",2612,0,"rCG46529 [Rattus norvegicus]","gi|3845606|dbj|AB019393.1|",2024,0,"Rattus norvegicus mRNA for myocilin, complete cds","Q9R1J4",1006,0,"Myocilin",".",".",".",".","pfam02191","OLF","Olfactomedin-like domain.","GO:0001649|osteoblast differentiation;GO:0001953|negative regulation of cell-matrix adhesion;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0014734|skeletal muscle hypertrophy;GO:0021675|nerve development;GO:0022011|myelination in peripheral nervous system;GO:0030335|positive regulation of cell migration;GO:0031175|neuron projection development;GO:0035024|negative regulation of Rho protein signal transduction;GO:0038031|non-canonical Wnt signaling pathway via JNK cascade;GO:0038133|ERBB2-ERBB3 signaling pathway;GO:0043408|regulation of MAPK cascade;GO:0045162|clustering of voltage-gated sodium channels;GO:0051496|positive regulation of stress fiber assembly;GO:0051497|negative regulation of stress fiber assembly;GO:0051894|positive regulation of focal adhesion assembly;GO:0051897|positive regulation of protein kinase B signaling;GO:0051901|positive regulation of mitochondrial depolarization;GO:0060348|bone development;GO:1900026|positive regulation of substrate adhesion-dependent cell spreading;GO:1990090|cellular response to nerve growth factor stimulus;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005741|mitochondrial outer membrane;GO:0005743|mitochondrial inner membrane;GO:0005758|mitochondrial intermembrane space;GO:0005783|endoplasmic reticulum;GO:0005791|rough endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005929|cilium;GO:0031410|cytoplasmic vesicle;GO:0033268|node of Ranvier;GO:0035748|myelin sheath abaxonal region;GO:0043220|Schmidt-Lanterman incisure;GO:0062023|collagen-containing extracellular matrix;GO:0070062|extracellular exosome;GO:0097453|mesaxon;","GO:0001968|fibronectin binding;GO:0003674|molecular_function;GO:0005109|frizzled binding;GO:0030971|receptor tyrosine kinase binding;GO:0032027|myosin light chain binding;GO:0046872|metal ion binding;","K23027","MYOC; myocilin"]
["ENSRNOG00000031211",30,2.490799816,186,11.9654615,0.208165796,-2.264195059,{"v":5.94753e-22,"d":"5.95E-22"},{"v":2.38577e-21,"d":"2.39E-21"},"down","yes","Acsm5","protein_coding","chr1:173863041-173898588:+","gi|33086508|gb|AAP92566.1|",5048,0,"Aa2-174 [Rattus norvegicus]","gi|33086665|gb|AY325244.1|",2865,0,"Rattus norvegicus Cc1-38 mRNA, complete cds","Q6AYT9",1127,0,"Acyl-coenzyme A synthetase ACSM5, mitochondrial","MA2912",363,{"v":8e-113,"d":"8.00E-113"},"COG0365","pfam00501","AMP-binding","AMP-binding enzyme.","GO:0006633|fatty acid biosynthetic process;GO:0006637|acyl-CoA metabolic process;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005759|mitochondrial matrix;","GO:0003674|molecular_function;GO:0004321|fatty-acyl-CoA synthase activity;GO:0005524|ATP binding;GO:0005525|GTP binding;GO:0015645|fatty acid ligase activity;GO:0031956|medium-chain fatty acid-CoA ligase activity;GO:0046872|metal ion binding;GO:0047760|butyrate-CoA ligase activity;","K01896","ACSM; medium-chain acyl-CoA synthetase [EC:6.2.1.2]"]
["ENSRNOG00000007886",28,2.324746495,180,11.57947887,0.200764345,-2.316425018,{"v":7.61234e-22,"d":"7.61E-22"},{"v":3.04594e-21,"d":"3.05E-21"},"down","yes","Orm1","protein_coding","chr5:76772941-76776154:+","gi|16757980|ref|NP_445740.1|",528,{"v":2e-62,"d":"2.00E-62"},"alpha-1-acid glycoprotein precursor [Rattus norvegicus]","gi|298906865|emb|FQ228584.1|",478,0,"Rattus norvegicus TL0ADA6YH24 mRNA sequence","P02764",207,{"v":5e-64,"d":"5.00E-64"},"Alpha-1-acid glycoprotein",".",".",".",".","pfam00061","Lipocalin","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.","GO:0002438|acute inflammatory response to antigenic stimulus;GO:0002439|chronic inflammatory response to antigenic stimulus;GO:0002682|regulation of immune system process;GO:0006953|acute-phase response;GO:0009410|response to xenobiotic stimulus;GO:0014070|response to organic cyclic compound;GO:0031100|animal organ regeneration;GO:0032496|response to lipopolysaccharide;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032732|positive regulation of interleukin-1 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0033197|response to vitamin E;GO:0071300|cellular response to retinoic acid;GO:0071378|cellular response to growth hormone stimulus;GO:0071385|cellular response to glucocorticoid stimulus;","GO:0005615|extracellular space;","GO:0036094|small molecule binding;","K17308","ORM, AGP; alpha-1-acid glycoprotein"]
["ENSRNOG00000056658",96,7.97055941,339,21.80801854,0.365487557,-1.452105806,{"v":8.13258e-22,"d":"8.13E-22"},{"v":3.25004E-21,"d":"3.25E-21"},"down","yes","Xylt1","protein_coding","chr1:171643925-171926783:+","gi|564298206|ref|XP_006223520.1|",4562,0,"PREDICTED: xylosyltransferase 1 isoform X1 [Rattus norvegicus]","gi|672014162|ref|XM_006223458.2|",5997,0,"PREDICTED: Rattus norvegicus xylosyltransferase 1 (Xylt1), transcript variant X1, mRNA","Q9EPI1",1685,0,"Xylosyltransferase 1 (Fragment)",".",".",".",".","pfam12529","Xylo_C","Xylosyltransferase C terminal. This domain family is found in eukaryotes, and is typically between 169 and 183 amino acids in length. The family is found in association with pfam02485. There is a single completely conserved residue G that may be functionally important. Xylosyltransferases are enzymes involved in the biosynthesis of the glycosaminoglycan linker region in proteoglycans.","GO:0015012|heparan sulfate proteoglycan biosynthetic process;GO:0030166|proteoglycan biosynthetic process;GO:0030206|chondroitin sulfate biosynthetic process;GO:0034605|cellular response to heat;GO:0043931|ossification involved in bone maturation;GO:0048681|negative regulation of axon regeneration;GO:0048706|embryonic skeletal system development;GO:0050650|chondroitin sulfate proteoglycan biosynthetic process;GO:0070555|response to interleukin-1;","GO:0000137|Golgi cis cisterna;GO:0000139|Golgi membrane;GO:0005575|cellular_component;GO:0005615|extracellular space;","GO:0003674|molecular_function;GO:0030158|protein xylosyltransferase activity;GO:0046872|metal ion binding;","K00771","XYLT; protein xylosyltransferase [EC:2.4.2.26]"]
["ENSRNOG00000039076",230,19.09613192,598,38.46960203,0.496395359,-1.010438467,{"v":1.00632E-21,"d":"1.01E-21"},{"v":4.00157e-21,"d":"4.00E-21"},"down","yes","Spaca6","protein_coding","chr1:58677797-58688562:+","gi|209180413|ref|NP_001129192.1|",1607,0,"uncharacterized protein LOC688452 precursor [Rattus norvegicus]","gi|209180412|ref|NM_001135720.1|",1112,0,"Rattus norvegicus hypothetical protein LOC688452 (LOC688452), mRNA","E9Q8Q8",498,{"v":4E-175,"d":"4.00E-175"},"Sperm acrosome membrane-associated protein 6",".",".",".",".","pfam00047","ig","Immunoglobulin domain. Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions. The Pfam alignments do not include the first and last strand of the immunoglobulin-like domain.","GO:0007342|fusion of sperm to egg plasma membrane involved in single fertilization;","GO:0001669|acrosomal vesicle;GO:0016021|integral component of membrane;",".","K25514","SPACA6; sperm acrosome membrane-associated protein 6"]
["ENSRNOG00000004753",48,3.985279705,229,14.73167034,0.270524632,-1.886168131,{"v":2.01246e-21,"d":"2.01E-21"},{"v":7.93824e-21,"d":"7.94E-21"},"down","yes","Napb","protein_coding","chr3:136133428-136179345:-","gi|29789104|ref|NP_062606.1|",1550,0,"beta-soluble NSF attachment protein [Mus musculus]","gi|672047296|ref|XM_008762275.1|",3097,0,"PREDICTED: Rattus norvegicus N-ethylmaleimide-sensitive factor attachment protein, beta (Napb), transcript variant X1, mRNA","P28663",601,0,"Beta-soluble NSF attachment protein",".",".",".",".","pfam14938","SNAP","Soluble NSF attachment protein, SNAP. The soluble NSF attachment protein (SNAP) proteins are involved in vesicular transport between the endoplasmic reticulum and Golgi apparatus. They act as adaptors between SNARE (integral membrane SNAP receptor) proteins and NSF (N-ethylmaleimide-sensitive factor). They are structurally similar to TPR repeats.","GO:0002090|regulation of receptor internalization;GO:0006886|intracellular protein transport;GO:0008150|biological_process;GO:0010807|regulation of synaptic vesicle priming;GO:0032984|protein-containing complex disassembly;GO:0035249|synaptic transmission, glutamatergic;GO:0035494|SNARE complex disassembly;GO:0043462|regulation of ATPase activity;","GO:0005575|cellular_component;GO:0005774|vacuolar membrane;GO:0031201|SNARE complex;GO:0070044|synaptobrevin 2-SNAP-25-syntaxin-1a complex;GO:0098793|presynapse;GO:0098794|postsynapse;GO:0098978|glutamatergic synapse;","GO:0000149|SNARE binding;GO:0003674|molecular_function;GO:0005483|soluble NSF attachment protein activity;GO:0019905|syntaxin binding;",".","."]
["ENSRNOG00000003538",73,6.060946218,286,18.39850532,0.329426011,-1.601973622,{"v":2.62714e-21,"d":"2.63E-21"},{"v":1.03374E-20,"d":"1.03E-20"},"down","yes","Adamts4","protein_coding","chr13:83670183-83680065:+","gi|149040662|gb|EDL94619.1|",4090,0,"a disintegrin and metallopeptidase with thrombospondin motifs 4 [Rattus norvegicus]","gi|281306770|ref|NM_023959.1|",3309,0,"Rattus norvegicus ADAM metallopeptidase with thrombospondin type 1 motif, 4 (Adamts4), mRNA","Q8BNJ2",1497,0,"A disintegrin and metalloproteinase with thrombospondin motifs 4",".",".",".",".","pfam05986","ADAM_spacer1","ADAM-TS Spacer 1. This family represents the Spacer-1 region from the ADAM-TS family of metalloproteinases.","GO:0006508|proteolysis;GO:0030198|extracellular matrix organization;GO:0042742|defense response to bacterium;GO:0044691|tooth eruption;","GO:0005615|extracellular space;GO:0016607|nuclear speck;GO:0031012|extracellular matrix;","GO:0002020|protease binding;GO:0004222|metalloendopeptidase activity;GO:0008233|peptidase activity;GO:0008237|metallopeptidase activity;GO:0046872|metal ion binding;","K07764","ADAMTS4; a disintegrin and metalloproteinase with thrombospondin motifs 4 [EC:3.4.24.82]"]
["ENSRNOG00000008706",149,12.37097242,442,28.43405368,0.435075932,-1.200660883,{"v":2.91826e-21,"d":"2.92E-21"},{"v":1.14406E-20,"d":"1.14E-20"},"down","yes","Tbx3","protein_coding","chr12:36881445-36893708:-","gi|31745146|ref|NP_853669.1|",3037,0,"T-box transcription factor TBX3 [Rattus norvegicus]","gi|672072989|ref|XM_006249416.2|",3317,0,"PREDICTED: Rattus norvegicus T-box 3 (Tbx3), transcript variant X2, mRNA","Q7TST9",1174,0,"T-box transcription factor TBX3",".",".",".",".","pfam00907","T-box","T-box. The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001501|skeletal system development;GO:0001568|blood vessel development;GO:0001701|in utero embryonic development;GO:0001708|cell fate specification;GO:0001947|heart looping;GO:0003007|heart morphogenesis;GO:0003151|outflow tract morphogenesis;GO:0003167|atrioventricular bundle cell differentiation;GO:0003205|cardiac chamber development;GO:0003272|endocardial cushion formation;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007417|central nervous system development;GO:0007569|cell aging;GO:0008284|positive regulation of cell proliferation;GO:0008595|anterior/posterior axis specification, embryo;GO:0009887|animal organ morphogenesis;GO:0010159|specification of animal organ position;GO:0019827|stem cell population maintenance;GO:0021761|limbic system development;GO:0030539|male genitalia development;GO:0030540|female genitalia development;GO:0030857|negative regulation of epithelial cell differentiation;GO:0030879|mammary gland development;GO:0032275|luteinizing hormone secretion;GO:0035050|embryonic heart tube development;GO:0035108|limb morphogenesis;GO:0035115|embryonic forelimb morphogenesis;GO:0035116|embryonic hindlimb morphogenesis;GO:0035136|forelimb morphogenesis;GO:0036302|atrioventricular canal development;GO:0042127|regulation of cell proliferation;GO:0042733|embryonic digit morphogenesis;GO:0043066|negative regulation of apoptotic process;GO:0045662|negative regulation of myoblast differentiation;GO:0045787|positive regulation of cell cycle;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046884|follicle-stimulating hormone secretion;GO:0048332|mesoderm morphogenesis;GO:0051145|smooth muscle cell differentiation;GO:0055007|cardiac muscle cell differentiation;GO:0060021|roof of mouth development;GO:0060317|cardiac epithelial to mesenchymal transition;GO:0060412|ventricular septum morphogenesis;GO:0060444|branching involved in mammary gland duct morphogenesis;GO:0060596|mammary placode formation;GO:0060923|cardiac muscle cell fate commitment;GO:0060931|sinoatrial node cell development;GO:0072105|ureteric peristalsis;GO:0090398|cellular senescence;GO:1905072|cardiac jelly development;GO:1905222|atrioventricular canal morphogenesis;GO:2000137|negative regulation of cell proliferation involved in heart morphogenesis;GO:2000648|positive regulation of stem cell proliferation;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0043565|sequence-specific DNA binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;GO:1990837|sequence-specific double-stranded DNA binding;","K10177","TBX3; T-box protein 3"]
["ENSRNOG00000011964",179,14.86177223,499,32.10088865,0.462970742,-1.111007072,{"v":3.31815e-21,"d":"3.32E-21"},{"v":1.29924e-20,"d":"1.30E-20"},"down","yes","Abcd4","protein_coding","chr6:104246468-104280276:-","gi|117414145|ref|NP_001013118.2|",2265,0,"ATP-binding cassette sub-family D member 4 [Rattus norvegicus]","gi|58400822|gb|BC089214.1|",1765,0,"Rattus norvegicus ATP-binding cassette, sub-family D (ALD), member 4, mRNA (cDNA clone IMAGE:7302205), complete cds","O89016",846,0,"ATP-binding cassette sub-family D member 4","sll0182",130,{"v":1e-30,"d":"1.00E-30"},"COG4178","pfam06472","ABC_membrane_2","ABC transporter transmembrane region 2. This domain covers the transmembrane of a small family of ABC transporters and shares sequence similarity with pfam00664. Mutations in this domain in human ABCD3 (PMP70) are believed responsible for Zellweger Syndrome-2; mutations in human ABCD1 (ALD) are responsible for recessive X-linked adrenoleukodystrophy. A Saccharomyces cerevisiae homolog is involved in the import of long-chain fatty acids.","GO:0006635|fatty acid beta-oxidation;GO:0007031|peroxisome organization;GO:0009235|cobalamin metabolic process;GO:0015889|cobalamin transport;GO:0015910|peroxisomal long-chain fatty acid import;GO:0042760|very long-chain fatty acid catabolic process;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0005765|lysosomal membrane;GO:0005777|peroxisome;GO:0005778|peroxisomal membrane;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0005324|long-chain fatty acid transporter activity;GO:0005524|ATP binding;GO:0015420|cobalamin-transporting ATPase activity;GO:0042626|ATPase activity, coupled to transmembrane movement of substances;","K05678","ABCD4, PXMP1L; ATP-binding cassette, subfamily D (ALD), member 4"]
["ENSRNOG00000004019",155,12.86913238,453,29.1416885,0.441605584,-1.179169679,{"v":3.51112e-21,"d":"3.51E-21"},{"v":1.37228E-20,"d":"1.37E-20"},"down","yes","Phlda1","protein_coding","chr7:46967409-46969861:+","gi|256985148|ref|NP_058876.2|",1254,{"v":1e-163,"d":"1.00E-163"},"pleckstrin homology-like domain family A member 1 [Rattus norvegicus]","gi|256985147|ref|NM_017180.2|",1811,0,"Rattus norvegicus pleckstrin homology-like domain, family A, member 1 (Phlda1), mRNA","Q9QZA1",487,{"v":4E-165,"d":"4.00E-165"},"Pleckstrin homology-like domain family A member 1",".",".",".",".","pfam13796","Sensor","Putative sensor. This family is often found at the N-terminus of proteins containing pfam07730 and pfam02518. The N-termini of proteins containing these two domains often function in stimulus sensing.","GO:0006915|apoptotic process;GO:0021879|forebrain neuron differentiation;GO:0043065|positive regulation of apoptotic process;GO:0045210|FasL biosynthetic process;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0031410|cytoplasmic vesicle;","GO:1901981|phosphatidylinositol phosphate binding;","K23793","PHLDA; pleckstrin homology-like domain family A"]
["ENSRNOG00000009043",97,8.053586071,336,21.61502723,0.372591993,-1.424331424,{"v":4.59243e-21,"d":"4.59E-21"},{"v":1.78399e-20,"d":"1.78E-20"},"down","yes","Piwil4","protein_coding","chr8:11536520-11579761:-","gi|402794768|ref|NP_001258062.1|",4386,0,"piwi-like protein 4 [Rattus norvegicus]","gi|402794767|ref|NM_001271133.1|",3109,0,"Rattus norvegicus piwi-like RNA-mediated gene silencing 4 (Piwil4), mRNA","Q4G033",1672,0,"Piwi-like protein 4",".",".",".",".","pfam02171","Piwi","Piwi domain. This domain is found in the protein Piwi and its relatives. The function of this domain is the dsRNA guided hydrolysis of ssRNA. Determination of the crystal structure of Argonaute reveals that PIWI is an RNase H domain, and identifies Argonaute as Slicer, the enzyme that cleaves mRNA in the RNAi RISC complex. In addition, Mg+2 dependence and production of 3'-OH and 5' phosphate products are shared characteristics of RNaseH and RISC. The PIWI domain core has a tertiary structure belonging to the RNase H family of enzymes. RNase H fold proteins all have a five-stranded mixed beta-sheet surrounded by helices. By analogy to RNase H enzymes which cleave single-stranded RNA guided by the DNA strand in an RNA/DNA hybrid, the PIWI domain can be inferred to cleave single-stranded RNA, for example mRNA, guided by double stranded siRNA.","GO:0006417|regulation of translation;GO:0007283|spermatogenesis;GO:0010529|negative regulation of transposition;GO:0010669|epithelial structure maintenance;GO:0030154|cell differentiation;GO:0031047|gene silencing by RNA;GO:0034587|piRNA metabolic process;GO:0043046|DNA methylation involved in gamete generation;GO:0051321|meiotic cell cycle;GO:0061178|regulation of insulin secretion involved in cellular response to glucose stimulus;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0043186|P granule;GO:0071547|piP-body;","GO:0003723|RNA binding;GO:0034584|piRNA binding;","K02156","AUB, PIWI; aubergine"]
["ENSRNOG00000058271",116,9.631092621,375,24.12391432,0.399234241,-1.324692634,{"v":4.73776E-21,"d":"4.74E-21"},{"v":1.83933e-20,"d":"1.84E-20"},"down","yes","Chpt1","protein_coding","chr7:22863027-22915103:-","gi|564358905|ref|XP_006241290.1|",2328,0,"PREDICTED: cholinephosphotransferase 1 isoform X1 [Rattus norvegicus]","gi|672058253|ref|XM_006241228.2|",1540,0,"PREDICTED: Rattus norvegicus choline phosphotransferase 1 (Chpt1), transcript variant X1, mRNA","Q66H21",717,0,"Cholinephosphotransferase 1","SPAC22A12.10",118,{"v":1E-27,"d":"1.00E-27"},"COG5050","pfam01066","CDP-OH_P_transf","CDP-alcohol phosphatidyltransferase. All of these members have the ability to catalyse the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.","GO:0006656|phosphatidylcholine biosynthetic process;GO:0006657|CDP-choline pathway;GO:0006663|platelet activating factor biosynthetic process;","GO:0000139|Golgi membrane;GO:0005789|endoplasmic reticulum membrane;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;","GO:0004142|diacylglycerol cholinephosphotransferase activity;GO:0016780|phosphotransferase activity, for other substituted phosphate groups;GO:0046872|metal ion binding;","K00994","CHPT1, CPT1; diacylglycerol cholinephosphotransferase [EC:2.7.8.2]"]
["ENSRNOG00000065772",72,5.977919558,280,18.01252269,0.331875754,-1.591284859,{"v":1.04514E-20,"d":"1.05E-20"},{"v":4.01364e-20,"d":"4.01E-20"},"down","yes","ENSRNOG00000065772","protein_coding","chr17:74728811-74736094:+","gi|672030279|ref|XP_008772248.1|",1703,0,"PREDICTED: uncharacterized protein LOC102547897 [Rattus norvegicus]","gi|672030278|ref|XM_008774026.1|",2427,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102547897 (LOC102547897), mRNA","Q6AYB4",147,{"v":1E-35,"d":"1.00E-35"},"Heat shock 70 kDa protein 14","SPAC22A12.15c",80.1,{"v":2E-14,"d":"2.00E-14"},"COG0443","pfam00012","HSP70","Hsp70 protein. Hsp70 chaperones help to fold many proteins. Hsp70 assisted folding involves repeated cycles of substrate binding and release. Hsp70 activity is ATP dependent. Hsp70 proteins are made up of two regions: the amino terminus is the ATPase domain and the carboxyl terminus is the substrate binding region.",".",".",".",".","."]
["ENSRNOG00000020951",0,0.04151333,95,6.111391628,0.006792779,-7.201782452,{"v":1.34816E-20,"d":"1.35E-20"},{"v":5.14029e-20,"d":"5.14E-20"},"down","yes","Slc4a1","protein_coding","chr10:87306872-87323117:-","gi|76443687|ref|NP_036783.2|",3965,0,"band 3 anion transport protein [Rattus norvegicus]","gi|55250403|gb|BC085748.1|",3538,0,"Rattus norvegicus solute carrier family 4 (anion exchanger), member 1, mRNA (cDNA clone MGC:93554 IMAGE:7126960), complete cds","P23562",1523,0,"Band 3 anion transport protein",".",".",".",".","pfam00955","HCO3_cotransp","HCO3- transporter family. This family contains Band 3 anion exchange proteins that exchange CL-/HCO3-. This family also includes cotransporters of Na+/HCO3-.","GO:0006820|anion transport;GO:0006821|chloride transport;GO:0007596|blood coagulation;GO:0007623|circadian rhythm;GO:0009414|response to water deprivation;GO:0010037|response to carbon dioxide;GO:0010446|response to alkaline pH;GO:0010447|response to acidic pH;GO:0014823|response to activity;GO:0015698|inorganic anion transport;GO:0015701|bicarbonate transport;GO:0017121|phospholipid scrambling;GO:0031667|response to nutrient levels;GO:0035811|negative regulation of urine volume;GO:0042102|positive regulation of T cell proliferation;GO:0042542|response to hydrogen peroxide;GO:0045852|pH elevation;GO:0046685|response to arsenic-containing substance;GO:0048821|erythrocyte development;GO:0050801|ion homeostasis;GO:0051354|negative regulation of oxidoreductase activity;GO:0051453|regulation of intracellular pH;GO:0055085|transmembrane transport;GO:0072659|protein localization to plasma membrane;GO:0098656|anion transmembrane transport;GO:1902476|chloride transmembrane transport;GO:1904539|negative regulation of glycolytic process through fructose-6-phosphate;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009898|cytoplasmic side of plasma membrane;GO:0009986|cell surface;GO:0014704|intercalated disc;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0030018|Z disc;GO:0030863|cortical cytoskeleton;","GO:0003779|actin binding;GO:0005452|inorganic anion exchanger activity;GO:0008022|protein C-terminus binding;GO:0015106|bicarbonate transmembrane transporter activity;GO:0015108|chloride transmembrane transporter activity;GO:0015301|anion:anion antiporter activity;GO:0019899|enzyme binding;GO:0022857|transmembrane transporter activity;GO:0030492|hemoglobin binding;GO:0030506|ankyrin binding;GO:0042803|protein homodimerization activity;GO:0044877|protein-containing complex binding;","K06573","SLC4A1, AE1, CD233; solute carrier family 4 (anion exchanger), member 1"]
["ENSRNOG00000006653",86,7.140292805,308,19.81377496,0.360370137,-1.47244863,{"v":2.36622E-20,"d":"2.37E-20"},{"v":8.92616e-20,"d":"8.93E-20"},"down","yes","Slc38a4","protein_coding","chr7:128144807-128202995:-","gi|18543357|ref|NP_570104.1|",2680,0,"sodium-coupled neutral amino acid transporter 4 [Rattus norvegicus]","gi|66910541|gb|BC097292.1|",1929,0,"Rattus norvegicus solute carrier family 38, member 4, mRNA (cDNA clone MGC:114273 IMAGE:7462761), complete cds","Q9EQ25",1036,0,"Sodium-coupled neutral amino acid transporter 4","YEL064c",65.9,{"v":2e-10,"d":"2.00E-10"},"COG0814","pfam01490","Aa_trans","Transmembrane amino acid transporter protein. This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.","GO:0003333|amino acid transmembrane transport;GO:0006814|sodium ion transport;","GO:0005887|integral component of plasma membrane;","GO:0015171|amino acid transmembrane transporter activity;GO:0015293|symporter activity;","K14991","SLC38A4, SNAT4; solute carrier family 38 (sodium-coupled neutral amino acid transporter), member 4"]
["ENSRNOG00000010100",140,11.62373247,417,26.82579272,0.433304342,-1.2065474,{"v":2.71437e-20,"d":"2.71E-20"},{"v":1.02275E-19,"d":"1.02E-19"},"down","yes","Tyw5","protein_coding","chr9:58961106-58979188:-","gi|281427194|ref|NP_001163944.1|",1687,0,"tRNA wybutosine-synthesizing protein 5 [Rattus norvegicus]","gi|281427193|ref|NM_001170473.1|",1472,0,"Rattus norvegicus tRNA-yW synthesizing protein 5 (Tyw5), transcript variant 1, mRNA","A2RSX7",636,0,"tRNA wybutosine-synthesizing protein 5",".",".",".",".","pfam13621","Cupin_8","Cupin-like domain. This cupin like domain shares similarity to the JmjC domain.","GO:0031591|wybutosine biosynthetic process;",".","GO:0000049|tRNA binding;GO:0005506|iron ion binding;GO:0016706|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0042803|protein homodimerization activity;GO:0102524|tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity;","K18066","TYW5; tRNA wybutosine-synthesizing protein 5 [EC:1.14.11.42]"]
["ENSRNOG00000018310",31,2.573826476,180,11.57947887,0.222274811,-2.16958363,{"v":2.75676e-20,"d":"2.76E-20"},{"v":1.0381E-19,"d":"1.04E-19"},"down","yes","Eno4","protein_coding","chr1:258096432-258128984:+","gi|564334485|ref|XP_006231731.1|",2849,0,"PREDICTED: enolase-like protein ENO4 isoform X1 [Rattus norvegicus]","gi|672040743|ref|XM_006231669.2|",3145,0,"PREDICTED: Rattus norvegicus enolase family member 4 (Eno4), transcript variant X1, mRNA","Q8C042",988,0,"Enolase 4","FN1764",100,{"v":2e-21,"d":"2.00E-21"},"COG0148","pfam00113","Enolase_C","Enolase, C-terminal TIM barrel domain.","GO:0006096|glycolytic process;GO:0008150|biological_process;GO:0030317|flagellated sperm motility;GO:0044782|cilium organization;","GO:0000015|phosphopyruvate hydratase complex;GO:0005575|cellular_component;GO:0097228|sperm principal piece;","GO:0000287|magnesium ion binding;GO:0003674|molecular_function;GO:0004634|phosphopyruvate hydratase activity;","K01689","ENO, eno; enolase [EC:4.2.1.11]"]
["ENSRNOG00000029330",170,14.11453229,474,30.4926277,0.462883436,-1.111279157,{"v":3.1365e-20,"d":"3.14E-20"},{"v":1.17832e-19,"d":"1.18E-19"},"down","yes","Ca5b","protein_coding","chrX:30474784-30533837:+","gi|53850632|ref|NP_001005551.1|",1602,0,"carbonic anhydrase 5B, mitochondrial precursor [Rattus norvegicus]","gi|672087334|ref|XM_006256859.2|",1811,0,"PREDICTED: Rattus norvegicus carbonic anhydrase 5b, mitochondrial (Car5b), transcript variant X1, mRNA","Q66HG6",621,0,"Carbonic anhydrase 5B, mitochondrial","BH0360",114,{"v":4e-27,"d":"4.00E-27"},"COG3338","pfam00194","Carb_anhydrase","Eukaryotic-type carbonic anhydrase.","GO:0006730|one-carbon metabolic process;GO:0009617|response to bacterium;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;","GO:0004089|carbonate dehydratase activity;GO:0008270|zinc ion binding;GO:0016836|hydro-lyase activity;","K01672","CA; carbonic anhydrase [EC:4.2.1.1]"]
["ENSRNOG00000027151",130,10.79346587,396,25.47485352,0.423690988,-1.238915651,{"v":4.1573e-20,"d":"4.16E-20"},{"v":1.55361E-19,"d":"1.55E-19"},"down","yes","Lrrc58","protein_coding","chr11:62847562-62862829:-","gi|312434031|ref|NP_001182487.1|",1198,{"v":2e-148,"d":"2.00E-148"},"leucine-rich repeat-containing protein 58 [Rattus norvegicus]","gi|110347494|ref|NM_177093.3|",1476,0,"Mus musculus leucine rich repeat containing 58 (Lrrc58), mRNA",".",".",".",".","alr0124_1",69.3,{"v":4e-11,"d":"4.00E-11"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.",".",".",".",".","."]
["ENSRNOG00000049289",208,17.26954539,543,34.93142793,0.494384181,-1.016295513,{"v":4.7821e-20,"d":"4.78E-20"},{"v":1.77982e-19,"d":"1.78E-19"},"down","yes","ENSRNOG00000049289","protein_coding","chr8:37119988-37132519:+","gi|764020103|ref|NP_001292144.1|",4554,0,"roundabout homolog 4-like [Rattus norvegicus]","gi|764020102|ref|NM_001305215.1|",3762,0,"Rattus norvegicus roundabout homolog 4-like (LOC100911068), mRNA","Q80W87",1624,0,"Roundabout homolog 4",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0030334|regulation of cell migration;GO:0030336|negative regulation of cell migration;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;","GO:0038023|signaling receptor activity;","K06784","ROBO4; roundabout, axon guidance receptor 4"]
["ENSRNOG00000061768",85,7.057266145,302,19.42779233,0.363256207,-1.460940647,{"v":8.99377e-20,"d":"8.99E-20"},{"v":3.30881e-19,"d":"3.31E-19"},"down","yes","Slc43a3","protein_coding","chr3:70009313-70029749:+","gi|564341663|ref|XP_006234532.1|",2308,0,"PREDICTED: solute carrier family 43 member 3 isoform X1 [Rattus norvegicus]","gi|157820138|ref|NM_001107743.1|",2027,0,"Rattus norvegicus solute carrier family 43, member 3 (Slc43a3), mRNA","A2AVZ9",790,0,"Solute carrier family 43 member 3",".",".",".",".","pfam07690","MFS_1","Major Facilitator Superfamily.","GO:0055085|transmembrane transport;","GO:0016021|integral component of membrane;","GO:0022857|transmembrane transporter activity;","K08230","SLC43A3; MFS transporter, LAT3 family, solute carrier family 43, member 3"]
["ENSRNOG00000067139",50,4.151333026,224,14.41001815,0.288086592,-1.795425576,{"v":9.93793e-20,"d":"9.94E-20"},{"v":3.64568e-19,"d":"3.65E-19"},"down","yes","Rpl10l","protein_coding","chr6:84543540-84545816:-","gi|946668211|ref|XP_014419151.1|",1145,{"v":5e-149,"d":"5.00E-149"},"PREDICTED: 60S ribosomal protein L10 isoform X1 [Camelus ferus]","gi|22296791|gb|AC125344.2|",1308,0,"Mus musculus BAC clone RP24-332H21 from 12, complete sequence","P86048",443,{"v":7e-150,"d":"7.00E-150"},"60S ribosomal protein L10-like","SPAP7G5.05",315,{"v":1E-100,"d":"1.00E-100"},"COG0197","pfam00252","Ribosomal_L16","Ribosomal protein L16p/L10e.",".",".",".",".","."]
["ENSRNOG00000025757",97,8.053586071,326,20.97172285,0.384021195,-1.380742156,{"v":1.29036E-19,"d":"1.29E-19"},{"v":4.7066e-19,"d":"4.71E-19"},"down","yes","Myh6","protein_coding","chr15:28417616-28441720:-","gi|186659510|ref|NP_058935.2|",9186,0,"myosin-6 [Rattus norvegicus]","gi|186659509|ref|NM_017239.2|",5914,0,"Rattus norvegicus myosin, heavy chain 6, cardiac muscle, alpha (Myh6), mRNA","P02563",3523,0,"Myosin-6","SPCC645.05c",775,0,"COG5022","pfam01576","Myosin_tail_1","Myosin tail. The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.","GO:0001701|in utero embryonic development;GO:0002026|regulation of the force of heart contraction;GO:0002027|regulation of heart rate;GO:0006936|muscle contraction;GO:0006941|striated muscle contraction;GO:0007512|adult heart development;GO:0007522|visceral muscle development;GO:0007568|aging;GO:0008016|regulation of heart contraction;GO:0008217|regulation of blood pressure;GO:0009408|response to heat;GO:0014898|cardiac muscle hypertrophy in response to stress;GO:0030048|actin filament-based movement;GO:0030049|muscle filament sliding;GO:0030239|myofibril assembly;GO:0043462|regulation of ATPase activity;GO:0045214|sarcomere organization;GO:0046034|ATP metabolic process;GO:0055009|atrial cardiac muscle tissue morphogenesis;GO:0055010|ventricular cardiac muscle tissue morphogenesis;GO:0055013|cardiac muscle cell development;GO:0060048|cardiac muscle contraction;GO:0060420|regulation of heart growth;GO:1905243|cellular response to 3,3',5-triiodo-L-thyronine;","GO:0001725|stress fiber;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005859|muscle myosin complex;GO:0016459|myosin complex;GO:0030016|myofibril;GO:0030018|Z disc;GO:0032982|myosin filament;","GO:0000146|microfilament motor activity;GO:0005516|calmodulin binding;GO:0005524|ATP binding;GO:0019901|protein kinase binding;GO:0030899|calcium-dependent ATPase activity;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;GO:0051015|actin filament binding;","K17751","MYH6_7; myosin heavy chain 6/7"]
["ENSRNOG00000065844",97,8.053586071,326,20.97172285,0.384021195,-1.380742156,{"v":1.29036E-19,"d":"1.29E-19"},{"v":4.7066e-19,"d":"4.71E-19"},"down","yes","ENSRNOG00000065844","protein_coding","chr10:105518792-105520817:-","gi|26330153|dbj|BAC28815.1|",215,{"v":3e-17,"d":"3.00E-17"},"unnamed protein product [Mus musculus]","gi|74188009|dbj|AK162948.1|",951,0,"Mus musculus adult male spinal cord cDNA, RIKEN full-length enriched library, clone:A330069N23 product:hypothetical protein, full insert sequence",".",".",".",".",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.",".",".",".",".","."]
["ENSRNOG00000010608",189,15.69203884,504,32.42254085,0.483985475,-1.046964343,{"v":1.407E-19,"d":"1.41E-19"},{"v":5.11748e-19,"d":"5.12E-19"},"down","yes","Cep162","protein_coding","chr8:88149726-88206830:-","gi|456367253|ref|NP_001263989.1|",6890,0,"centrosomal protein of 162 kDa [Rattus norvegicus]","gi|672062689|ref|XM_006243475.2|",5499,0,"PREDICTED: Rattus norvegicus centrosomal protein 162 (Cep162), transcript variant X1, mRNA","Q4KLH6",2633,0,"Centrosomal protein of 162 kDa",".",".",".",".","pfam10174","Cast","RIM-binding protein of the cytomatrix active zone. This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.","GO:0060271|cilium assembly;","GO:0005634|nucleus;GO:0005813|centrosome;GO:0005814|centriole;GO:0005819|spindle;GO:0005879|axonemal microtubule;",".","K16809","CEP162; centrosomal protein CEP162"]
["ENSRNOG00000070490",160,13.28426568,448,28.82003631,0.460938548,-1.117353671,{"v":2.31132e-19,"d":"2.31E-19"},{"v":8.34492e-19,"d":"8.34E-19"},"down","yes","ENSRNOG00000070490","lncRNA","chr3:56733057-56734666:-",".",".",".",".","gi|672045726|ref|XM_006234352.2|",1610,0,"PREDICTED: Rattus norvegicus pyruvate dehydrogenase kinase, isozyme 1 (Pdk1), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam00660","SRP1_TIP1","Seripauperin and TIP1 family.",".",".",".",".","."]
["ENSRNOG00000053638",11,0.913293266,116,7.462330829,0.122387132,-3.03047622,{"v":4.94618e-19,"d":"4.95E-19"},{"v":1.75702e-18,"d":"1.76E-18"},"down","yes","Clec12b","protein_coding","chr4:162827462-162838946:-","gi|157819437|ref|NP_001102823.1|",1367,0,"C-type lectin domain family 12 member B [Rattus norvegicus]","gi|157819436|ref|NM_001109353.1|",1487,0,"Rattus norvegicus C-type lectin domain family 12, member B (Clec12b), mRNA","Q149M0",473,{"v":3e-164,"d":"3.00E-164"},"C-type lectin domain family 12 member B",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0002769|natural killer cell inhibitory signaling pathway;GO:0045953|negative regulation of natural killer cell mediated cytotoxicity;GO:2000272|negative regulation of signaling receptor activity;","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0032991|protein-containing complex;","GO:0019903|protein phosphatase binding;GO:0030246|carbohydrate binding;GO:0030547|receptor inhibitor activity;","K17517","CLEC12B; C-type lectin domain family 12 member B"]
["ENSRNOG00000021795",109,9.049905997,345,22.19400117,0.407763608,-1.294195071,{"v":7.36429e-19,"d":"7.36E-19"},{"v":2.58158e-18,"d":"2.58E-18"},"down","yes","Fam227a","protein_coding","chr7:111174362-111216483:-","gi|256000825|ref|NP_001124053.2|",3181,0,"protein FAM227A [Rattus norvegicus]","gi|686661133|ref|NM_001130581.3|",3219,0,"Rattus norvegicus family with sequence similarity 227, member A (Fam227a), mRNA",".",".",".",".",".",".",".",".","pfam14922","FWWh","Protein of unknown function. This is a family of eukaryotic proteins. Most members carry a highly distinctive, conserved sequence motif of FWWh, where h represents a hydrophobic residue. The function of the family is not known.",".",".",".",".","."]
["ENSRNOG00000025551",51,4.234359687,221,14.21702684,0.297837216,-1.747404061,{"v":7.9658E-19,"d":"7.97E-19"},{"v":2.78939e-18,"d":"2.79E-18"},"down","yes","Rgs22","protein_coding","chr7:67188519-67308875:-","gi|564359806|ref|XP_006241610.1|",6347,0,"PREDICTED: regulator of G-protein signaling 22 isoform X2 [Rattus norvegicus]","gi|672059064|ref|XM_006241548.2|",5189,0,"PREDICTED: Rattus norvegicus regulator of G-protein signaling 22 (Rgs22), transcript variant X2, mRNA","G3UYX5",2183,0,"Regulator of G-protein signaling 22",".",".",".",".","pfam00615","RGS","Regulator of G protein signaling domain. RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.","GO:0009966|regulation of signal transduction;","GO:0001650|fibrillar center;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0015629|actin cytoskeleton;","GO:0001965|G-protein alpha-subunit binding;",".","."]
["ENSRNOG00000033658",195,16.1901988,508,32.6798626,0.495418203,-1.013281217,{"v":9.01331e-19,"d":"9.01E-19"},{"v":3.15446e-18,"d":"3.15E-18"},"down","yes","Kntc1","protein_coding","chr12:32769020-32839561:-","gi|672072960|ref|XP_008767450.1|",11399,0,"PREDICTED: kinetochore-associated protein 1 isoform X1 [Rattus norvegicus]","gi|672072959|ref|XM_008769228.1|",6944,0,"PREDICTED: Rattus norvegicus kinetochore associated 1 (Kntc1), transcript variant X1, mRNA","Q8C3Y4",4054,0,"Kinetochore-associated protein 1",".",".",".",".","pfam10493","Rod_C","Rough deal protein C-terminal region. Rod, the Rough deal protein, displays a dynamic intracellular staining pattern, localizing first to kinetochores in pro-metaphase, but moving to kinetochore microtubules at metaphase. Early in anaphase the protein is once again restricted to the kinetochores, where it persists until the end of telophase. This behaviour is in all respects similar to that described for ZW10, and indeed the two proteins function together, localisation of each depending upon the other. These two proteins are found at the kinetochore in complex with a third, Zwilch, in both flies and humans. The C-terminus is the most conserved part of the protein. During pro-metaphase, the ZW10-Rod complex, dynein/dynactin, and Mad2 all accumulate on unattached kinetochores; microtubule capture leads to Mad2 depletion as it is carried off by dynein/dynactin; ZW10-Rod complex accumulation continues, replenishing kinetochore dynein. The continuing recruitment of the ZW10-Rod complex during metaphase may serve to maintain adequate dynein/dynactin complex on kinetochores for assisting chromatid movement during anaphase. The ZW10-Rod complex acts as a bridge whose association with Zwint-1 links Mad1 and Mad2, components that are directly responsible for generating the diffusible 'wait anaphase' signal, to a structural, inner kinetochore complex containing Mis12 and KNL-1AF15q14, the last of which has been proved to be essential for kinetochore assembly in C. elegans. Removal of ZW10 or Rod inactivates the mitotic checkpoint.","GO:0000070|mitotic sister chromatid segregation;GO:0007094|mitotic spindle assembly checkpoint;GO:1903394|protein localization to kinetochore involved in kinetochore assembly;","GO:0000922|spindle pole;GO:0005737|cytoplasm;GO:0005828|kinetochore microtubule;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0015629|actin cytoskeleton;GO:1990423|RZZ complex;","GO:0031267|small GTPase binding;","K11577","KNTC1, ROD; kinetochore-associated protein 1"]
["ENSRNOG00000027770",40,3.321066421,194,12.48010501,0.266108852,-1.909911591,{"v":1.12729E-18,"d":"1.13E-18"},{"v":3.91527e-18,"d":"3.92E-18"},"down","yes","Trpm3","protein_coding","chr1:219672892-220560717:+","gi|54144620|ref|NP_796315.2|",6689,0,"transient receptor potential cation channel subfamily M member 3 isoform f [Mus musculus]","gi|133892589|ref|NM_177341.4|",4542,0,"Mus musculus transient receptor potential cation channel, subfamily M, member 3 (Trpm3), transcript variant 6, mRNA","Q9HCF6",2498,0,"Transient receptor potential cation channel subfamily M member 3",".",".",".",".","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0006812|cation transport;GO:0016048|detection of temperature stimulus;GO:0050951|sensory perception of temperature stimulus;GO:0051262|protein tetramerization;GO:0098655|cation transmembrane transport;","GO:0005887|integral component of plasma membrane;","GO:0005227|calcium activated cation channel activity;GO:0005261|cation channel activity;","K04978","TRPM3; transient receptor potential cation channel subfamily M member 3"]
["ENSRNOG00000060460",85,7.057266145,294,18.91314883,0.373140729,-1.422208253,{"v":1.36889E-18,"d":"1.37E-18"},{"v":4.73389e-18,"d":"4.73E-18"},"down","yes","Clec1a","protein_coding","chr4:162877346-162901247:-","gi|157823785|ref|NP_001102723.1|",1317,{"v":5e-170,"d":"5.00E-170"},"C-type lectin domain family 1 member A [Rattus norvegicus]","gi|157823784|ref|NM_001109253.1|",3299,0,"Rattus norvegicus C-type lectin domain family 1, member A (Clec1a), mRNA","Q8BWY2",494,{"v":6e-165,"d":"6.00E-165"},"C-type lectin domain family 1 member A",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type",".","GO:0016021|integral component of membrane;","GO:0030246|carbohydrate binding;","K10069","CLEC1A; C-type lectin domain family 1 member A"]
["ENSRNOG00000016724",191,15.85809216,499,32.10088865,0.494007887,-1.017394021,{"v":1.40131e-18,"d":"1.40E-18"},{"v":4.83809E-18,"d":"4.84E-18"},"down","yes","Epb41l3","protein_coding","chr9:109016113-109260607:+","gi|16758808|ref|NP_446379.1|",4985,0,"band 4.1-like protein 3 [Rattus norvegicus]","gi|16758807|ref|NM_053927.1|",4528,0,"Rattus norvegicus erythrocyte membrane protein band 4.1-like 3 (Epb41l3), mRNA","Q9Y2J2",1575,0,"Band 4.1-like protein 3",".",".",".",".","pfam05902","4_1_CTD","4.1 protein C-terminal domain (CTD). At the C-terminus of all known 4.1 proteins is a sequence domain unique to these proteins, known as the C-terminal domain (CTD). Mammalian CTDs are associated with a growing number of protein-protein interactions, although such activities have yet to be associated with invertebrate CTDs. Mammalian CTDs are generally defined by sequence alignment as encoded by exons 18-21. Comparison of known vertebrate 4.1 proteins with invertebrate 4.1 proteins indicates that mammalian 4.1 exon 19 represents a vertebrate adaptation that extends the sequence of the CTD with a Ser/Thr-rich sequence. The CTD was first described as a 22/24-kDa domain by chymotryptic digestion of erythrocyte 4.1 (4.1R). CTD is thought to represent an independent folding structure which has gained function since the divergence of vertebrates from invertebrates.","GO:0001558|regulation of cell growth;GO:0002175|protein localization to paranode region of axon;GO:0008360|regulation of cell shape;GO:0030866|cortical actin cytoskeleton organization;GO:0030913|paranodal junction assembly;GO:0031032|actomyosin structure organization;GO:0043217|myelin maintenance;GO:0048812|neuron projection morphogenesis;GO:0071205|protein localization to juxtaparanode region of axon;GO:0072659|protein localization to plasma membrane;","GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0014069|postsynaptic density;GO:0030054|cell junction;GO:0030673|axolemma;GO:0033270|paranode region of axon;GO:0044224|juxtaparanode region of axon;","GO:0003779|actin binding;GO:0005198|structural molecule activity;","K23961","EPB41L1_2_3; band 4.1-like protein 1/2/3"]
["ENSRNOG00000022844",28,2.324746495,163,10.48586142,0.221702958,-2.173300076,{"v":1.48465E-18,"d":"1.48E-18"},{"v":5.12029e-18,"d":"5.12E-18"},"down","yes","Pdzrn4","protein_coding","chr7:123816961-123965491:+","gi|257196174|ref|NP_001101577.2|",3738,0,"PDZ domain containing RING finger 4 [Rattus norvegicus]","gi|257196173|ref|NM_001108107.2|",3368,0,"Rattus norvegicus PDZ domain containing RING finger 4 (Pdzrn4), mRNA","Q6ZMN7",1203,0,"PDZ domain-containing RING finger protein 4",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.",".",".",".","K15682","PDZRN3_4, LNX3_4; ligand of Numb protein X 3/4 [EC:2.3.2.27]"]
["ENSRNOG00000043416",140,11.62373247,403,25.92516659,0.448357099,-1.157279855,{"v":1.67086E-18,"d":"1.67E-18"},{"v":5.75939e-18,"d":"5.76E-18"},"down","yes","Bcl3","protein_coding","chr1:79471369-79485607:-","gi|157821585|ref|NP_001102892.1|",1841,0,"B-cell lymphoma 3 protein [Rattus norvegicus]","gi|157821584|ref|NM_001109422.1|",1788,0,"Rattus norvegicus B-cell CLL/lymphoma 3 (Bcl3), mRNA","Q9Z2F6",679,0,"B-cell lymphoma 3 protein homolog","all2748",82,{"v":8e-16,"d":"8.00E-16"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0002268|follicular dendritic cell differentiation;GO:0002315|marginal zone B cell differentiation;GO:0002455|humoral immune response mediated by circulating immunoglobulin;GO:0002467|germinal center formation;GO:0006606|protein import into nucleus;GO:0006974|cellular response to DNA damage stimulus;GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0009615|response to virus;GO:0010225|response to UV-C;GO:0019730|antimicrobial humoral response;GO:0030198|extracellular matrix organization;GO:0030330|DNA damage response, signal transduction by p53 class mediator;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0032717|negative regulation of interleukin-8 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032729|positive regulation of interferon-gamma production;GO:0032733|positive regulation of interleukin-10 production;GO:0042088|T-helper 1 type immune response;GO:0042742|defense response to bacterium;GO:0042771|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0042832|defense response to protozoan;GO:0042981|regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0045064|T-helper 2 cell differentiation;GO:0045727|positive regulation of translation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046426|negative regulation of JAK-STAT cascade;GO:0048536|spleen development;GO:0051101|regulation of DNA binding;GO:1901222|regulation of NIK/NF-kappaB signaling;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0030496|midbody;GO:0032991|protein-containing complex;GO:0032996|Bcl3-Bcl10 complex;GO:0033257|Bcl3/NF-kappaB2 complex;GO:0043231|intracellular membrane-bounded organelle;","GO:0003713|transcription coactivator activity;GO:0003714|transcription corepressor activity;GO:0030674|protein binding, bridging;GO:0042826|histone deacetylase binding;","K09258","BCL3; B-cell CLL/lymphoma 3 protein"]
["ENSRNOG00000005600",118,9.797145942,360,23.15895775,0.423039156,-1.241136891,{"v":1.80535e-18,"d":"1.81E-18"},{"v":6.20958e-18,"d":"6.21E-18"},"down","yes","Nr4a2","protein_coding","chr3:41689851-41697877:-","gi|803020647|ref|XP_011992369.1|",2767,0,"PREDICTED: nuclear receptor subfamily 4 group A member 2 isoform X2 [Ovis aries]","gi|73476626|gb|DQ092632.1|",1786,0,"Rattus norvegicus nuclear receptor subfamily 4 group A member 2 variant NURR1b (Nr4a2) mRNA, complete cds, alternatively spliced","P43354",1028,0,"Nuclear receptor subfamily 4 group A member 2",".",".",".",".","pfam00105","zf-C4","Zinc finger, C4 type (two domains). In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001666|response to hypoxia;GO:0001764|neuron migration;GO:0001975|response to amphetamine;GO:0006351|transcription, DNA-templated;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007399|nervous system development;GO:0007611|learning or memory;GO:0008344|adult locomotory behavior;GO:0009791|post-embryonic development;GO:0010035|response to inorganic substance;GO:0010467|gene expression;GO:0010468|regulation of gene expression;GO:0017085|response to insecticide;GO:0021952|central nervous system projection neuron axonogenesis;GO:0021953|central nervous system neuron differentiation;GO:0021986|habenula development;GO:0021987|cerebral cortex development;GO:0030182|neuron differentiation;GO:0030522|intracellular receptor signaling pathway;GO:0031668|cellular response to extracellular stimulus;GO:0034599|cellular response to oxidative stress;GO:0042053|regulation of dopamine metabolic process;GO:0042416|dopamine biosynthetic process;GO:0042417|dopamine metabolic process;GO:0042551|neuron maturation;GO:0043085|positive regulation of catalytic activity;GO:0043524|negative regulation of neuron apoptotic process;GO:0043576|regulation of respiratory gaseous exchange;GO:0045444|fat cell differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051866|general adaptation syndrome;GO:0060041|retina development in camera-type eye;GO:0071376|cellular response to corticotropin-releasing hormone stimulus;GO:0071542|dopaminergic neuron differentiation;GO:2001234|negative regulation of apoptotic signaling pathway;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005667|transcription factor complex;GO:0005737|cytoplasm;GO:0016607|nuclear speck;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0004879|nuclear receptor activity;GO:0008270|zinc ion binding;GO:0035259|glucocorticoid receptor binding;GO:0043565|sequence-specific DNA binding;GO:0046982|protein heterodimerization activity;GO:1990837|sequence-specific double-stranded DNA binding;","K08558","NR4A2, NURR1; nuclear receptor subfamily 4 group A member 2"]
["ENSRNOG00000005299",181,15.02782556,479,30.81427989,0.487690305,-1.035962802,{"v":2.16546E-18,"d":"2.17E-18"},{"v":7.4282e-18,"d":"7.43E-18"},"down","yes","Kif5a","protein_coding","chr7:63049424-63092858:-","gi|47058980|ref|NP_997688.1|",4979,0,"kinesin heavy chain isoform 5A [Rattus norvegicus]","gi|298898969|emb|FQ212220.1|",5952,0,"Rattus norvegicus TL0AAA65YC10 mRNA sequence","Q6QLM7",1922,0,"Kinesin heavy chain isoform 5A","SPAC1834.07",323,{"v":1e-94,"d":"1.00E-94"},"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0007017|microtubule-based process;GO:0007018|microtubule-based movement;GO:0007411|axon guidance;GO:0016192|vesicle-mediated transport;GO:0021766|hippocampus development;GO:0021794|thalamus development;GO:0021987|cerebral cortex development;GO:0030705|cytoskeleton-dependent intracellular transport;GO:0048489|synaptic vesicle transport;GO:0048666|neuron development;GO:0071361|cellular response to ethanol;GO:0098971|anterograde dendritic transport of neurotransmitter receptor complex;GO:0099641|anterograde axonal protein transport;GO:1904647|response to rotenone;GO:1990049|retrograde neuronal dense core vesicle transport;GO:1990090|cellular response to nerve growth factor stimulus;","GO:0000932|P-body;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005871|kinesin complex;GO:0005874|microtubule;GO:0030424|axon;GO:0030425|dendrite;GO:0032839|dendrite cytoplasm;GO:0035253|ciliary rootlet;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0048471|perinuclear region of cytoplasm;GO:0090724|central region of growth cone;GO:0097440|apical dendrite;GO:1904115|axon cytoplasm;","GO:0003777|microtubule motor activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0008017|microtubule binding;GO:0008574|ATP-dependent microtubule motor activity, plus-end-directed;GO:0016887|ATPase activity;GO:0019894|kinesin binding;GO:0044877|protein-containing complex binding;GO:0097110|scaffold protein binding;","K10396","KIF5; kinesin family member 5"]
["ENSRNOG00000007189",21,1.743559871,143,9.19925266,0.189532774,-2.399480758,{"v":2.30303E-18,"d":"2.30E-18"},{"v":7.89163e-18,"d":"7.89E-18"},"down","yes","Ttc22","protein_coding","chr5:121406326-121423130:+","gi|157821039|ref|NP_001100141.1|",2853,0,"tetratricopeptide repeat protein 22 [Rattus norvegicus]","gi|157821038|ref|NM_001106671.1|",2553,0,"Rattus norvegicus tetratricopeptide repeat domain 22 (Ttc22), mRNA",".",".",".",".",".",".",".",".","pfam13414","TPR_11","TPR repeat.",".",".",".","K24933","TTC22; tetratricopeptide repeat protein 22"]
["ENSRNOG00000007426",97,8.053586071,317,20.3927489,0.394924005,-1.340353032,{"v":2.4412e-18,"d":"2.44E-18"},{"v":8.35169e-18,"d":"8.35E-18"},"down","yes","Tmem64","protein_coding","chr5:28698918-28745330:+","gi|392340363|ref|XP_003754051.1|",1291,{"v":3e-172,"d":"3.00E-172"},"PREDICTED: transmembrane protein 64 [Rattus norvegicus]","gi|672019166|ref|XM_003754003.3|",1375,0,"PREDICTED: Rattus norvegicus transmembrane protein 64 (Tmem64), mRNA","Q3U145",466,{"v":1e-159,"d":"1.00E-159"},"Transmembrane protein 64","slr0305",63.5,{"v":1E-10,"d":"1.00E-10"},"COG0398","pfam09335","SNARE_assoc","SNARE associated Golgi protein. This is a family of SNARE associated Golgi proteins. The yeast member of this family localizes with the t-SNARE Tlg2.","GO:0043462|regulation of ATPase activity;GO:0045600|positive regulation of fat cell differentiation;GO:0045668|negative regulation of osteoblast differentiation;GO:0045672|positive regulation of osteoclast differentiation;GO:0045780|positive regulation of bone resorption;GO:0051480|regulation of cytosolic calcium ion concentration;GO:0090090|negative regulation of canonical Wnt signaling pathway;","GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000029528",15,1.245399908,125,8.041304773,0.154875352,-2.690820533,{"v":2.93822e-18,"d":"2.94E-18"},{"v":1.00199E-17,"d":"1.00E-17"},"down","yes","Cbs","protein_coding","chr20:9708090-9732764:-","gi|543960|sp|P32232.3|CBS_RAT",2948,0,"RecName: Full=Cystathionine beta-synthase; AltName: Full=Beta-thionase; AltName: Full=Hemoprotein H-450; AltName: Full=Serine sulfhydrase","gi|1364273|gb|M88344.1|RATRCBSA",2504,0,"Rat cystathionine beta-synthase (CBS) mRNA, complete cds (type 1 of four alternatively spliced mRNAs)","P32232",1140,0,"Cystathionine beta-synthase","YGR155w_1",338,{"v":1e-106,"d":"1.00E-106"},"COG0031","pfam00291","PALP","Pyridoxal-phosphate dependent enzyme. Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.","GO:0001958|endochondral ossification;GO:0001974|blood vessel remodeling;GO:0006535|cysteine biosynthetic process from serine;GO:0006563|L-serine metabolic process;GO:0006565|L-serine catabolic process;GO:0006801|superoxide metabolic process;GO:0010749|regulation of nitric oxide mediated signal transduction;GO:0019343|cysteine biosynthetic process via cystathionine;GO:0019344|cysteine biosynthetic process;GO:0019346|transsulfuration;GO:0019448|L-cysteine catabolic process;GO:0021587|cerebellum morphogenesis;GO:0031667|response to nutrient levels;GO:0042262|DNA protection;GO:0043066|negative regulation of apoptotic process;GO:0043418|homocysteine catabolic process;GO:0043506|regulation of JUN kinase activity;GO:0050667|homocysteine metabolic process;GO:0051593|response to folic acid;GO:0060135|maternal process involved in female pregnancy;GO:0060351|cartilage development involved in endochondral bone morphogenesis;GO:0070814|hydrogen sulfide biosynthetic process;GO:0071456|cellular response to hypoxia;GO:0097746|regulation of blood vessel diameter;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004122|cystathionine beta-synthase activity;GO:0019825|oxygen binding;GO:0019899|enzyme binding;GO:0020037|heme binding;GO:0030170|pyridoxal phosphate binding;GO:0031625|ubiquitin protein ligase binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0046872|metal ion binding;GO:0050421|nitrite reductase (NO-forming) activity;GO:0070025|carbon monoxide binding;GO:0070026|nitric oxide binding;GO:0072341|modified amino acid binding;GO:1904047|S-adenosyl-L-methionine binding;","K01697","CBS; cystathionine beta-synthase [EC:4.2.1.22]"]
["ENSRNOG00000047005",72,5.977919558,264,16.98323568,0.351989437,-1.506395962,{"v":3.18748e-18,"d":"3.19E-18"},{"v":1.0841E-17,"d":"1.08E-17"},"down","yes","Kcnk5","protein_coding","chr15:4122442-4164718:+","gi|87252701|ref|NP_001034605.1|",2418,0,"potassium channel subfamily K member 5 [Rattus norvegicus]","gi|121583860|ref|NM_001039516.2|",3464,0,"Rattus norvegicus potassium two pore domain channel subfamily K member 5 (Kcnk5), mRNA","O95279",815,0,"Potassium channel subfamily K member 5","MA2218",50.8,3e-06,"COG1226","pfam07885","Ion_trans_2","Ion channel. This family includes the two membrane helix type ion channels found in bacteria.","GO:0030322|stabilization of membrane potential;GO:0060075|regulation of resting membrane potential;GO:0071805|potassium ion transmembrane transport;GO:0097623|potassium ion export across plasma membrane;GO:1990573|potassium ion import across plasma membrane;","GO:0005887|integral component of plasma membrane;","GO:0005249|voltage-gated potassium channel activity;GO:0005267|potassium channel activity;GO:0022841|potassium ion leak channel activity;","K04916","KCNK5, K2P5.1; potassium channel subfamily K member 5"]
["ENSRNOG00000054695",125,10.37833257,371,23.86659257,0.434847687,-1.201417936,{"v":4.08392e-18,"d":"4.08E-18"},{"v":1.38164E-17,"d":"1.38E-17"},"down","yes","Calcrl","protein_coding","chr3:69430120-69525910:-","gi|6978587|ref|NP_036849.1|",2240,0,"calcitonin gene-related peptide type 1 receptor precursor [Rattus norvegicus]","gi|672046080|ref|XM_006234438.2|",3152,0,"PREDICTED: Rattus norvegicus calcitonin receptor-like (Calcrl), transcript variant X1, mRNA","Q63118",867,0,"Calcitonin gene-related peptide type 1 receptor",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0001525|angiogenesis;GO:0006816|calcium ion transport;GO:0007166|cell surface receptor signaling pathway;GO:0007188|adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007507|heart development;GO:0008284|positive regulation of cell proliferation;GO:0015031|protein transport;GO:0031623|receptor internalization;GO:0045986|negative regulation of smooth muscle contraction;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0050728|negative regulation of inflammatory response;GO:0071329|cellular response to sucrose stimulus;GO:1990408|calcitonin gene-related peptide receptor signaling pathway;GO:1990410|adrenomedullin receptor signaling pathway;","GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0005768|endosome;GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:1903143|adrenomedullin receptor complex;GO:1990406|CGRP receptor complex;","GO:0001605|adrenomedullin receptor activity;GO:0001635|calcitonin gene-related peptide receptor activity;GO:0004948|calcitonin receptor activity;GO:0008528|G protein-coupled peptide receptor activity;GO:1990409|adrenomedullin binding;","K04577","CALCRL; calcitonin receptor-like"]
["ENSRNOG00000062479",9,0.747239945,105,6.754696009,0.110625251,-3.17624736,{"v":4.4549e-18,"d":"4.45E-18"},{"v":1.50556e-17,"d":"1.51E-17"},"down","yes","ENSRNOG00000062479","protein_coding","chr2:215692196-215697408:+","gi|293347239|ref|XP_002726534.1|",651,{"v":2e-69,"d":"2.00E-69"},"PREDICTED: uncharacterized protein LOC100364265 [Rattus norvegicus]","gi|33457292|gb|AC131744.3|",1640,0,"Mus musculus BAC clone RP23-50E10 from chromosome 3, complete sequence","P11260",155,{"v":3e-39,"d":"3.00E-39"},"LINE-1 retrotransposable element ORF1 protein",".",".",".",".","pfam02994","Transposase_22","L1 transposable element.",".",".",".",".","."]
["ENSRNOG00000013692",93,7.721479429,306,19.68511408,0.392249666,-1.350155875,{"v":6.13588e-18,"d":"6.14E-18"},{"v":2.05734e-17,"d":"2.06E-17"},"down","yes","Abhd18","protein_coding","chr2:123872386-123920231:+","gi|158563777|sp|Q4V7A8.2|ABD18_RAT",2462,0,"RecName: Full=Protein ABHD18; AltName: Full=Alpha/beta hydrolase domain-containing protein 18; Short=Abhydrolase domain-containing protein 18; Flags: Precursor","gi|167830471|ref|NM_001025039.2|",2274,0,"Rattus norvegicus abhydrolase domain containing 18 (Abhd18), mRNA","Q4V7A8",952,0,"Protein ABHD18",".",".",".",".","pfam09752","DUF2048","Uncharacterized conserved protein (DUF2048). The proteins in this family are conserved from plants to vertebrates. The function is unknown.",".","GO:0005576|extracellular region;",".",".","."]
["ENSRNOG00000026607",16,1.328426568,125,8.041304773,0.165200376,-2.597711128,{"v":1.24028E-17,"d":"1.24E-17"},{"v":4.10055e-17,"d":"4.10E-17"},"down","yes","Tnfsf18","protein_coding","chr13:73831252-73843169:+","gi|672027248|ref|XP_008760830.1|",867,{"v":1E-108,"d":"1.00E-108"},"PREDICTED: tumor necrosis factor ligand superfamily member 18 [Rattus norvegicus]","gi|672074632|ref|XM_008769705.1|",1924,0,"PREDICTED: Rattus norvegicus tumor necrosis factor (ligand) superfamily, member 18 (Tnfsf18), mRNA","Q7TS55",269,{"v":8e-84,"d":"8.00E-84"},"Tumor necrosis factor ligand superfamily member 18",".",".",".",".","pfam00229","TNF","TNF(tumor Necrosis Factor) family.","GO:0002309|T cell proliferation involved in immune response;GO:0002687|positive regulation of leukocyte migration;GO:0010759|positive regulation of macrophage chemotaxis;GO:0033209|tumor necrosis factor-mediated signaling pathway;GO:0042129|regulation of T cell proliferation;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0043254|regulation of protein complex assembly;GO:0045785|positive regulation of cell adhesion;GO:0050729|positive regulation of inflammatory response;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0090026|positive regulation of monocyte chemotaxis;GO:2000329|negative regulation of T-helper 17 cell lineage commitment;GO:2000508|regulation of dendritic cell chemotaxis;","GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0032813|tumor necrosis factor receptor superfamily binding;GO:0042802|identical protein binding;","K05479","TNFSF18, GITRL; tumor necrosis factor ligand superfamily member 18"]
["ENSRNOG00000006841",21,1.743559871,139,8.941930908,0.194986954,-2.358550494,{"v":1.44422e-17,"d":"1.44E-17"},{"v":4.7625e-17,"d":"4.76E-17"},"down","yes","Ano4","protein_coding","chr7:23329070-23738434:-","gi|568967784|ref|XP_006513818.1|",5729,0,"PREDICTED: anoctamin-4 isoform X2 [Mus musculus]","gi|755534677|ref|XM_006513755.2|",3859,0,"PREDICTED: Mus musculus anoctamin 4 (Ano4), transcript variant X1, mRNA","Q8C5H1",1915,0,"Anoctamin-4",".",".",".",".","pfam04547","Anoctamin","Calcium-activated chloride channel. The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.","GO:0006821|chloride transport;GO:0055085|transmembrane transport;GO:0061589|calcium activated phosphatidylserine scrambling;GO:0061590|calcium activated phosphatidylcholine scrambling;GO:0061591|calcium activated galactosylceramide scrambling;GO:1902476|chloride transmembrane transport;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0005229|intracellular calcium activated chloride channel activity;GO:0005254|chloride channel activity;GO:0017128|phospholipid scramblase activity;GO:0046983|protein dimerization activity;","K19499","ANO4, TMEM16D; anoctamin-4"]
["ENSRNOG00000017820",96,7.97055941,309,19.8781054,0.400971785,-1.318427371,{"v":1.66472e-17,"d":"1.66E-17"},{"v":5.47833e-17,"d":"5.48E-17"},"down","yes","Nqo2","protein_coding","chr17:30909187-30938320:-","gi|51948400|ref|NP_001004214.1|",1129,{"v":7e-149,"d":"7.00E-149"},"ribosyldihydronicotinamide dehydrogenase [quinone] [Rattus norvegicus]","gi|672081604|ref|XM_006253868.2|",834,0,"PREDICTED: Rattus norvegicus NAD(P)H dehydrogenase, quinone 2 (Nqo2), transcript variant X2, mRNA","Q6AY80",439,{"v":2E-150,"d":"2.00E-150"},"Ribosyldihydronicotinamide dehydrogenase [quinone]","MA0326",150,{"v":1e-40,"d":"1.00E-40"},"COG2249","pfam02525","Flavodoxin_2","Flavodoxin-like fold. This family consists of a domain with a flavodoxin-like fold. The family includes bacterial and eukaryotic NAD(P)H dehydrogenase (quinone) EC:1.6.99.2. These enzymes catalyse the NAD(P)H-dependent two-electron reductions of quinones and protect cells against damage by free radicals and reactive oxygen species.  This enzyme uses a FAD co-factor. The equation for this reaction is:- NAD(P)H + acceptor <=> NAD(P)(+) + reduced acceptor. This enzyme is also involved in the bioactivation of prodrugs used in chemotherapy. The family also includes acyl carrier protein phosphodiesterase EC:3.1.4.14. This enzyme converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine residue from ACP. This family is related to pfam03358 and pfam00258.","GO:0007613|memory;GO:0022900|electron transport chain;GO:0043525|positive regulation of neuron apoptotic process;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:1901662|quinone catabolic process;GO:1904707|positive regulation of vascular smooth muscle cell proliferation;GO:2000379|positive regulation of reactive oxygen species metabolic process;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0001512|dihydronicotinamide riboside quinone reductase activity;GO:0003674|molecular_function;GO:0003955|NAD(P)H dehydrogenase (quinone) activity;GO:0008270|zinc ion binding;GO:0009055|electron transfer activity;GO:0016491|oxidoreductase activity;GO:0016661|oxidoreductase activity, acting on other nitrogenous compounds as donors;GO:0031404|chloride ion binding;GO:0042803|protein homodimerization activity;GO:0071949|FAD binding;GO:1904408|melatonin binding;GO:1905594|resveratrol binding;","K08071","NQO2; ribosyldihydronicotinamide dehydrogenase (quinone) [EC:1.10.5.1]"]
["ENSRNOG00000013503",148,12.28794576,410,26.37547966,0.465885205,-1.101953578,{"v":1.71843e-17,"d":"1.72E-17"},{"v":5.64638e-17,"d":"5.65E-17"},"down","yes","Cdh24","protein_coding","chr15:28091637-28101340:-","gi|672028474|ref|XP_008766904.1|",3440,0,"PREDICTED: cadherin-24 [Rattus norvegicus]","gi|672028473|ref|XM_008768682.1|",3359,0,"PREDICTED: Rattus norvegicus cadherin 24, type 2 (Cdh24), mRNA","Q6PFX6",1303,0,"Cadherin-24",".",".",".",".","pfam01049","Cadherin_C","Cadherin cytoplasmic region. Cadherins are vital in cell-cell adhesion during tissue differentiation. Cadherins are linked to the cytoskeleton by catenins. Catenins bind to the cytoplasmic tail of the cadherin. Cadherins cluster to form foci of homophilic binding units. A key determinant to the strength of the binding that it is mediated by cadherins is the juxtamembrane region of the cadherin. This region induces clustering and also binds to the protein p120ctn.","GO:0000902|cell morphogenesis;GO:0007043|cell-cell junction assembly;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007275|multicellular organism development;GO:0008150|biological_process;GO:0016339|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0034332|adherens junction organization;GO:0098609|cell-cell adhesion;GO:0098742|cell-cell adhesion via plasma-membrane adhesion molecules;","GO:0005575|cellular_component;GO:0005911|cell-cell junction;GO:0005912|adherens junction;GO:0016021|integral component of membrane;GO:0016342|catenin complex;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;GO:0008013|beta-catenin binding;GO:0045294|alpha-catenin binding;GO:0045296|cadherin binding;GO:0070097|delta-catenin binding;","K06814","CDH24; cadherin-like 24"]
["ENSRNOG00000024027",175,14.52966559,459,29.52767113,0.492069474,-1.023066075,{"v":2.32975e-17,"d":"2.33E-17"},{"v":7.612e-17,"d":"7.61E-17"},"down","yes","Lemd3","protein_coding","chr7:56305448-56502474:-","gi|564359447|ref|XP_006241472.1|",3611,0,"PREDICTED: inner nuclear membrane protein Man1 isoform X1 [Rattus norvegicus]","gi|672021697|ref|XR_601757.1|",2868,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103692865 (LOC103692865), ncRNA","Q9WU40",1206,0,"Inner nuclear membrane protein Man1","STM1291",167,{"v":2E-45,"d":"2.00E-45"},"COG0229","pfam01641","SelR","SelR domain. Methionine sulfoxide reduction is an important process, by which cells regulate biological processes and cope with oxidative stress. MsrA, a protein involved in the reduction of methionine sulfoxides in proteins, has been known for four decades and has been extensively characterized with respect to structure and function. However, recent studies revealed that MsrA is only specific for methionine-S-sulfoxides. Because oxidized methionines occur in a mixture of R and S isomers in vivo, it was unclear how stereo-specific MsrA could be responsible for the reduction of all protein methionine sulfoxides. It appears that a second methionine sulfoxide reductase, SelR, evolved that is specific for methionine-R-sulfoxides, the activity that is different but complementary to that of MsrA. Thus, these proteins, working together, could reduce both stereoisomers of methionine sulfoxide. This domain is found both in SelR proteins and fused with the peptide methionine sulfoxide reductase enzymatic domain pfam01625. The domain has two conserved cysteine and histidines. The domain binds both selenium and zinc. The final cysteine is found to be replaced by the rare amino acid selenocysteine in some members of the family. This family has methionine-R-sulfoxide reductase activity.","GO:0001525|angiogenesis;GO:0002044|blood vessel endothelial cell migration involved in intussusceptive angiogenesis;GO:0006997|nucleus organization;GO:0006998|nuclear envelope organization;GO:0008150|biological_process;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030514|negative regulation of BMP signaling pathway;GO:0032926|negative regulation of activin receptor signaling pathway;GO:0035914|skeletal muscle cell differentiation;GO:0051726|regulation of cell cycle;GO:1902531|regulation of intracellular signal transduction;GO:1903053|regulation of extracellular matrix organization;","GO:0005575|cellular_component;GO:0005635|nuclear envelope;GO:0005637|nuclear inner membrane;GO:0005639|integral component of nuclear inner membrane;GO:0016021|integral component of membrane;GO:0031965|nuclear membrane;","GO:0003674|molecular_function;GO:0031490|chromatin DNA binding;","K19410","LEMD3; inner nuclear membrane protein Man1"]
["ENSRNOG00000008766",45,3.736199724,198,12.73742676,0.29332453,-1.769430368,{"v":2.67087E-17,"d":"2.67E-17"},{"v":8.70872E-17,"d":"8.71E-17"},"down","yes","Grin2b","protein_coding","chr4:168599546-169042279:-","gi|149049163|gb|EDM01617.1|",7896,0,"glutamate receptor, ionotropic, N-methyl D-aspartate 2B, isoform CRA_a [Rattus norvegicus]","gi|6980983|ref|NM_012574.1|",5253,0,"Rattus norvegicus glutamate ionotropic receptor NMDA type subunit 2B (Grin2b), mRNA","Q00960",3041,0,"Glutamate receptor ionotropic, NMDA 2B",".",".",".",".","pfam10565","NMDAR2_C","N-methyl D-aspartate receptor 2B3 C-terminus. This domain is found at the C-terminus of many NMDA-receptor proteins, many of which also carry the Ligated ion-channel family pfam00060 further upstream as well as the ANF_receptor family pfam01094. This region is predicted to be a large extra-cellular domain of the NMDA receptor proteins, being highly hydrophilic, and is thought to be integrally involved in the function of the receptor. The region also carries a number of potential N-glycosylation sites.","GO:0001508|action potential;GO:0001662|behavioral fear response;GO:0001666|response to hypoxia;GO:0001701|in utero embryonic development;GO:0001964|startle response;GO:0001967|suckling behavior;GO:0001975|response to amphetamine;GO:0006812|cation transport;GO:0006816|calcium ion transport;GO:0007268|chemical synaptic transmission;GO:0007423|sensory organ development;GO:0007611|learning or memory;GO:0007612|learning;GO:0007613|memory;GO:0007616|long-term memory;GO:0008306|associative learning;GO:0009612|response to mechanical stimulus;GO:0009636|response to toxic substance;GO:0009743|response to carbohydrate;GO:0010042|response to manganese ion;GO:0010243|response to organonitrogen compound;GO:0010350|cellular response to magnesium starvation;GO:0010738|regulation of protein kinase A signaling;GO:0010942|positive regulation of cell death;GO:0014049|positive regulation of glutamate secretion;GO:0014070|response to organic cyclic compound;GO:0014075|response to amine;GO:0019722|calcium-mediated signaling;GO:0021766|hippocampus development;GO:0021987|cerebral cortex development;GO:0032026|response to magnesium ion;GO:0033555|multicellular organismal response to stress;GO:0034097|response to cytokine;GO:0035235|ionotropic glutamate receptor signaling pathway;GO:0042220|response to cocaine;GO:0042596|fear response;GO:0043113|receptor clustering;GO:0043408|regulation of MAPK cascade;GO:0045471|response to ethanol;GO:0046960|sensitization;GO:0048167|regulation of synaptic plasticity;GO:0048169|regulation of long-term neuronal synaptic plasticity;GO:0048266|behavioral response to pain;GO:0048511|rhythmic process;GO:0050806|positive regulation of synaptic transmission;GO:0050966|detection of mechanical stimulus involved in sensory perception of pain;GO:0051290|protein heterotetramerization;GO:0051592|response to calcium ion;GO:0051597|response to methylmercury;GO:0051602|response to electrical stimulus;GO:0051707|response to other organism;GO:0060078|regulation of postsynaptic membrane potential;GO:0060079|excitatory postsynaptic potential;GO:0060291|long-term synaptic potentiation;GO:0060416|response to growth hormone;GO:0060992|response to fungicide;GO:0071230|cellular response to amino acid stimulus;GO:0071287|cellular response to manganese ion;GO:0071359|cellular response to dsRNA;GO:0071363|cellular response to growth factor stimulus;GO:0071386|cellular response to corticosterone stimulus;GO:0071396|cellular response to lipid;GO:0071407|cellular response to organic cyclic compound;GO:0097553|calcium ion transmembrane import into cytosol;GO:0098989|NMDA selective glutamate receptor signaling pathway;GO:0099566|regulation of postsynaptic cytosolic calcium ion concentration;GO:1901216|positive regulation of neuron death;GO:1902951|negative regulation of dendritic spine maintenance;GO:1904322|cellular response to forskolin;GO:1904644|cellular response to curcumin;GO:2001056|positive regulation of cysteine-type endopeptidase activity;","GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0005770|late endosome;GO:0005789|endoplasmic reticulum membrane;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0008021|synaptic vesicle;GO:0009986|cell surface;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0017146|NMDA selective glutamate receptor complex;GO:0030018|Z disc;GO:0042734|presynaptic membrane;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043083|synaptic cleft;GO:0043195|terminal bouton;GO:0043197|dendritic spine;GO:0044307|dendritic branch;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0097060|synaptic membrane;GO:0097440|apical dendrite;GO:0098686|hippocampal mossy fiber to CA3 synapse;GO:0098688|parallel fiber to Purkinje cell synapse;GO:0098794|postsynapse;GO:0098839|postsynaptic density membrane;GO:0098978|glutamatergic synapse;GO:0099056|integral component of presynaptic membrane;GO:0099061|integral component of postsynaptic density membrane;","GO:0004970|ionotropic glutamate receptor activity;GO:0004972|NMDA glutamate receptor activity;GO:0005102|signaling receptor binding;GO:0005149|interleukin-1 receptor binding;GO:0005234|extracellularly glutamate-gated ion channel activity;GO:0005261|cation channel activity;GO:0005262|calcium channel activity;GO:0005515|protein binding;GO:0008013|beta-catenin binding;GO:0008270|zinc ion binding;GO:0015276|ligand-gated ion channel activity;GO:0016594|glycine binding;GO:0016595|glutamate binding;GO:0022849|glutamate-gated calcium ion channel activity;GO:0031749|D2 dopamine receptor binding;GO:0035255|ionotropic glutamate receptor binding;GO:0036094|small molecule binding;GO:0038023|signaling receptor activity;GO:0042165|neurotransmitter binding;GO:0044877|protein-containing complex binding;GO:0050839|cell adhesion molecule binding;GO:0097110|scaffold protein binding;GO:0099529|neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential;GO:0099583|neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration;GO:1901363|heterocyclic compound binding;GO:1904315|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K05210","GRIN2B; glutamate receptor ionotropic, NMDA 2B"]
["ENSRNOG00000050072",82,6.808186163,278,17.88386182,0.380688815,-1.393315912,{"v":3.59603e-17,"d":"3.60E-17"},{"v":1.16689e-16,"d":"1.17E-16"},"down","yes","Jmjd7","protein_coding","chr3:106998477-107004538:+","gi|167900431|ref|NP_001108128.1|",1683,0,"jmjC domain-containing protein 7 [Rattus norvegicus]","gi|167900430|ref|NM_001114656.1|",1335,0,"Rattus norvegicus jumonji domain containing 7 (Jmjd7), mRNA","P0C872",639,0,"JmjC domain-containing protein 7",".",".",".",".","pfam13621","Cupin_8","Cupin-like domain. This cupin like domain shares similarity to the JmjC domain.","GO:0006508|proteolysis;GO:0018126|protein hydroxylation;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0004175|endopeptidase activity;GO:0004177|aminopeptidase activity;GO:0004497|monooxygenase activity;GO:0016706|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0035064|methylated histone binding;","K19219","JMJD7; peptidyl-lysine (3S)-dioxygenase / protease [EC:1.14.11.63 3.4.-.-]"]
["ENSRNOG00000020689",86,7.140292805,285,18.33417488,0.38945264,-1.360480198,{"v":5.4165e-17,"d":"5.42E-17"},{"v":1.74214e-16,"d":"1.74E-16"},"down","yes","Cpeb3","protein_coding","chr1:234751733-234931560:-","gi|672040273|ref|XP_008758601.1|",2998,0,"PREDICTED: cytoplasmic polyadenylation element-binding protein 3 isoform X1 [Rattus norvegicus]","gi|672014818|ref|XM_008774796.1|",4932,0,"PREDICTED: Rattus norvegicus cytoplasmic polyadenylation element binding protein 3 (Cpeb3), transcript variant X3, mRNA","Q7TN99",1144,0,"Cytoplasmic polyadenylation element-binding protein 3",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006412|translation;GO:0007616|long-term memory;GO:0017148|negative regulation of translation;GO:0045727|positive regulation of translation;GO:0048167|regulation of synaptic plasticity;GO:0050955|thermoception;GO:0060213|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening;GO:0060998|regulation of dendritic spine development;GO:0060999|positive regulation of dendritic spine development;GO:0061158|3'-UTR-mediated mRNA destabilization;GO:0071230|cellular response to amino acid stimulus;GO:1900153|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:1900248|negative regulation of cytoplasmic translational elongation;GO:1900273|positive regulation of long-term synaptic potentiation;GO:1900365|positive regulation of mRNA polyadenylation;GO:2000766|negative regulation of cytoplasmic translation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0030014|CCR4-NOT complex;GO:0030425|dendrite;GO:0030496|midbody;GO:0043005|neuron projection;GO:0045202|synapse;GO:0097440|apical dendrite;GO:0098794|postsynapse;GO:1990124|messenger ribonucleoprotein complex;","GO:0000900|translation repressor activity, mRNA regulatory element binding;GO:0003723|RNA binding;GO:0003730|mRNA 3'-UTR binding;GO:0008135|translation factor activity, RNA binding;GO:0035613|RNA stem-loop binding;GO:0035925|mRNA 3'-UTR AU-rich region binding;GO:0043022|ribosome binding;","K02602","CPEB, ORB; cytoplasmic polyadenylation element-binding protein"]
["ENSRNOG00000068016",156,12.95215904,420,27.01878404,0.47937609,-1.060770143,{"v":6.71078e-17,"d":"6.71E-17"},{"v":2.15409e-16,"d":"2.15E-16"},"down","yes","ENSRNOG00000068016","protein_coding","chr19:21909754-22356833:-","gi|672083970|ref|XP_008770468.1|",1034,{"v":2E-125,"d":"2.00E-125"},"PREDICTED: LOW QUALITY PROTEIN: disks large homolog 5-like isoform X2 [Rattus norvegicus]","gi|425703057|gb|AC246664.5|",2331,0,"Rattus norvegicus Y Chr BAC RNAEX-360A21 (Amplicon Express Rat SHR-Akr BAC library) complete sequence","P11260",79,{"v":7e-14,"d":"7.00E-14"},"LINE-1 retrotransposable element ORF1 protein",".",".",".",".","pfam02994","Transposase_22","L1 transposable element.",".",".",".",".","."]
["ENSRNOG00000025587",108,8.966879337,326,20.97172285,0.42756999,-1.225767496,{"v":1.41917e-16,"d":"1.42E-16"},{"v":4.49002e-16,"d":"4.49E-16"},"down","yes","Plagl1","protein_coding","chr1:7477177-7517228:+","gi|6981166|ref|NP_036892.1|",2080,0,"zinc finger protein PLAGL1 [Rattus norvegicus]","gi|158819032|ref|NM_012760.3|",2453,0,"Rattus norvegicus PLAG1 like zinc finger 1 (Plagl1), mRNA","Q9UM63",578,0,"Zinc finger protein PLAGL1","ECU03g0790",72,{"v":1e-12,"d":"1.00E-12"},"COG5048","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0006355|regulation of transcription, DNA-templated;GO:0010468|regulation of gene expression;GO:0035914|skeletal muscle cell differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005794|Golgi apparatus;GO:0016604|nuclear body;GO:0043231|intracellular membrane-bounded organelle;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;","K19485","PLAGL1; zinc finger protein PLAGL1"]
["ENSRNOG00000011892",2,0.166053321,73,4.696121987,0.035359669,-4.821751403,{"v":1.60632e-16,"d":"1.61E-16"},{"v":5.06707e-16,"d":"5.07E-16"},"down","yes","Slc36a2","protein_coding","chr10:39278046-39306082:-","gi|149052650|gb|EDM04467.1|",2381,0,"rCG34384 [Rattus norvegicus]","gi|183985819|gb|BC166414.1|",2285,0,"Rattus norvegicus solute carrier family 36 (proton/amino acid symporter), member 2, mRNA (cDNA clone MGC:187323 IMAGE:9027758), complete cds","Q8K415",894,0,"Proton-coupled amino acid transporter 2","YNL101w",132,{"v":5e-31,"d":"5.00E-31"},"COG0814","pfam01490","Aa_trans","Transmembrane amino acid transporter protein. This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.","GO:0003333|amino acid transmembrane transport;GO:0010155|regulation of proton transport;GO:0015808|L-alanine transport;GO:0015816|glycine transport;GO:0015824|proline transport;GO:0032973|amino acid export across plasma membrane;GO:0035524|proline transmembrane transport;GO:0070881|regulation of proline transport;GO:1900925|positive regulation of glycine import across plasma membrane;GO:1902600|proton transmembrane transport;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0005280|amino acid:proton symporter activity;GO:0015171|amino acid transmembrane transporter activity;GO:0015180|L-alanine transmembrane transporter activity;GO:0015187|glycine transmembrane transporter activity;GO:0015193|L-proline transmembrane transporter activity;","K14209","SLC36A, PAT; solute carrier family 36 (proton-coupled amino acid transporter)"]
["ENSRNOG00000069161",158,13.11821236,420,27.01878404,0.485521937,-1.042391613,{"v":1.81834e-16,"d":"1.82E-16"},{"v":5.72176e-16,"d":"5.72E-16"},"down","yes","ENSRNOG00000069161","lncRNA","chr17:66027501-66033568:-","gi|149032233|gb|EDL87139.1|",593,{"v":5e-66,"d":"5.00E-66"},"rCG63135 [Rattus norvegicus]","gi|240851455|gb|AC139609.2|",5421,0,"Rattus norvegicus CH230-381A11 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P11369",227,{"v":2e-58,"d":"2.00E-58"},"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam12488","DUF3704","Protein of unknown function (DUF3704). This domain family is found in eukaryotes, and is approximately 30 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000007224",170,14.11453229,441,28.36972324,0.497520972,-1.007170753,{"v":2.37088e-16,"d":"2.37E-16"},{"v":7.42757e-16,"d":"7.43E-16"},"down","yes","Bmt2","protein_coding","chr4:41879993-41945539:-","gi|157822869|ref|NP_001102691.1|",1819,0,"probable methyltransferase BTM2 homolog [Rattus norvegicus]","gi|158749562|ref|NM_175312.4|",2403,0,"Mus musculus RIKEN cDNA B630005N14 gene (B630005N14Rik), mRNA","Q8BXK4",692,0,"S-adenosylmethionine sensor upstream of mTORC1",".",".",".",".","pfam03901","Glyco_transf_22","Alg9-like mannosyltransferase family. Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.","GO:0032259|methylation;GO:0034198|cellular response to amino acid starvation;GO:1904262|negative regulation of TORC1 signaling;","GO:0140007|KICSTOR complex;GO:1990130|GATOR1 complex;","GO:0008168|methyltransferase activity;GO:1904047|S-adenosyl-L-methionine binding;","K18849","BMT2; 25S rRNA (adenine2142-N1)-methyltransferase [EC:2.1.1.286]"]
["ENSRNOG00000014323",97,8.053586071,302,19.42779233,0.414539436,-1.270418741,{"v":2.8547e-16,"d":"2.85E-16"},{"v":8.91707E-16,"d":"8.92E-16"},"down","yes","Extl2","protein_coding","chr2:203922187-203943653:+","gi|189181704|ref|NP_001094174.1|",1636,0,"exostosin-like 2 [Rattus norvegicus]","gi|672043998|ref|XM_006233215.2|",2348,0,"PREDICTED: Rattus norvegicus exostosin-like glycosyltransferase 2 (Extl2), transcript variant X1, mRNA","Q9ES89",602,0,"Exostosin-like 2",".",".",".",".","pfam09258","Glyco_transf_64","Glycosyl transferase family 64 domain. Members of this family catalyse the transfer reaction of N-acetylglucosamine and N-acetylgalactosamine from the respective UDP-sugars to the non-reducing end of [glucuronic acid]beta 1-3[galactose]beta 1-O-naphthalenemethanol, an acceptor substrate analog of the natural common linker of various glycosylaminoglycans. They are also required for the biosynthesis of heparan-sulphate.","GO:0006044|N-acetylglucosamine metabolic process;GO:0006486|protein glycosylation;GO:0019276|UDP-N-acetylgalactosamine metabolic process;","GO:0005654|nucleoplasm;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005829|cytosol;GO:0016021|integral component of membrane;","GO:0001888|glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity;GO:0005539|glycosaminoglycan binding;GO:0030145|manganese ion binding;GO:0035248|alpha-1,4-N-acetylgalactosaminyltransferase activity;GO:0047237|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity;","K02369","EXTL2; alpha-1,4-N-acetylglucosaminyltransferase EXTL2 [EC:2.4.1.223]"]
["ENSRNOG00000016103",107,8.883852676,321,20.65007066,0.430209311,-1.216889345,{"v":3.5604e-16,"d":"3.56E-16"},{"v":1.10512e-15,"d":"1.11E-15"},"down","yes","Nkd2","protein_coding","chr1:29441328-29470821:+","gi|672034128|ref|XP_008756915.1|",2118,0,"PREDICTED: protein naked cuticle homolog 2 isoform X3 [Rattus norvegicus]","gi|672034127|ref|XM_008758693.1|",4539,0,"PREDICTED: Rattus norvegicus naked cuticle homolog 2 (Drosophila) (Nkd2), transcript variant X3, mRNA","Q8VE28",745,0,"Protein naked cuticle homolog 2",".",".",".",".","pfam07271","Cytadhesin_P30","Cytadhesin P30/P32. This family consists of several Mycoplasma species specific Cytadhesin P32 and P30 proteins. P30 has been found to be membrane associated and localized on the tip organelle. It is thought that it is important in cytadherence and virulence.","GO:0010954|positive regulation of protein processing;GO:0016055|Wnt signaling pathway;GO:0030178|negative regulation of Wnt signaling pathway;GO:0032436|positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0048210|Golgi vesicle fusion to target membrane;GO:0072659|protein localization to plasma membrane;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:1903078|positive regulation of protein localization to plasma membrane;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016323|basolateral plasma membrane;GO:0016328|lateral plasma membrane;GO:0031410|cytoplasmic vesicle;GO:0070382|exocytic vesicle;GO:0071944|cell periphery;","GO:0005509|calcium ion binding;GO:0019838|growth factor binding;GO:0031625|ubiquitin protein ligase binding;GO:0032036|myosin heavy chain binding;GO:0051117|ATPase binding;","K03213","NKD; naked cuticle"]
["ENSRNOG00000067971",40,3.321066421,179,11.51514844,0.288408477,-1.793814526,{"v":4.64493e-16,"d":"4.64E-16"},{"v":1.43133e-15,"d":"1.43E-15"},"down","yes","Sprn","protein_coding","chr1:194943826-194948460:-","gi|149061483|gb|EDM11906.1|",482,{"v":9e-53,"d":"9.00E-53"},"rCG47900, isoform CRA_c [Rattus norvegicus]","gi|672038941|ref|XM_006230573.2|",2992,0,"PREDICTED: Rattus norvegicus shadow of prion protein homolog (zebrafish) (Sprn), transcript variant X1, mRNA","Q5BIV7",103,{"v":2e-23,"d":"2.00E-23"},"Shadow of prion protein",".",".",".",".","pfam14999","Shadoo","Shadow of prion protein, neuroprotective. This protein family is a Prion-like protein and its function is neuroprotective and similar to PrP(C)-like. Shadoo is mainly expressed in the brain, and highly expressed in the hippocampus, the area of the brain which co-ordinates memory as well as spatial memory and navigation. This protein may also alter the biological actions of normal and abnormal Prion Protein (PrP) which lead to lethal neurodegenerative diseases. This family of proteins is found in eukaryotes. Proteins in this family are approximately 150 amino acids in length, of which the first 90 are alanine rich.",".",".",".",".","."]
["ENSRNOG00000006553",139,11.54070581,381,24.50989695,0.47085901,-1.086632959,{"v":4.96709e-16,"d":"4.97E-16"},{"v":1.5284e-15,"d":"1.53E-15"},"down","yes","Bnc2","protein_coding","chr5:98687410-99079426:-","gi|625200748|ref|XP_007642184.1|",5342,0,"PREDICTED: zinc finger protein basonuclin-2 isoform X1 [Cricetulus griseus]","gi|672052839|ref|XM_008763775.1|",4086,0,"PREDICTED: Rattus norvegicus basonuclin 2 (Bnc2), transcript variant X1, mRNA","Q8BMQ3",2061,0,"Zinc finger protein basonuclin-2",".",".",".",".","pfam13894","zf-C2H2_4","C2H2-type zinc finger. This family contains a number of divergent C2H2 type zinc fingers.","GO:0003416|endochondral bone growth;GO:0006355|regulation of transcription, DNA-templated;GO:0043586|tongue development;GO:0060021|roof of mouth development;GO:0060485|mesenchyme development;","GO:0005634|nucleus;GO:0005654|nucleoplasm;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0003677|DNA binding;","K24146","BNC; zinc finger protein basonuclin"]
["ENSRNOG00000015075",153,12.70307906,406,26.1181579,0.48636964,-1.039874918,{"v":6.52573e-16,"d":"6.53E-16"},{"v":1.9917E-15,"d":"1.99E-15"},"down","yes","Stc1","protein_coding","chr15:44299621-44310264:+","gi|803011834|ref|XP_004004231.2|",1291,{"v":4e-168,"d":"4.00E-168"},"PREDICTED: stanniocalcin-1 [Ovis aries]","gi|51036665|ref|NM_031123.2|",2434,0,"Rattus norvegicus stanniocalcin 1 (Stc1), mRNA","P97574",485,{"v":4E-165,"d":"4.00E-165"},"Stanniocalcin-1",".",".",".",".","pfam03298","Stanniocalcin","Stanniocalcin family.","GO:0001503|ossification;GO:0001886|endothelial cell morphogenesis;GO:0003421|growth plate cartilage axis specification;GO:0006874|cellular calcium ion homeostasis;GO:0007165|signal transduction;GO:0007566|embryo implantation;GO:0010596|negative regulation of endothelial cell migration;GO:0014070|response to organic cyclic compound;GO:0030336|negative regulation of cell migration;GO:0033280|response to vitamin D;GO:0035988|chondrocyte proliferation;GO:0044070|regulation of anion transport;GO:0046697|decidualization;GO:0051926|negative regulation of calcium ion transport;GO:0060348|bone development;GO:0071320|cellular response to cAMP;GO:0071385|cellular response to glucocorticoid stimulus;GO:0071456|cellular response to hypoxia;GO:0086004|regulation of cardiac muscle cell contraction;GO:0090280|positive regulation of calcium ion import;GO:1903403|negative regulation of renal phosphate excretion;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0016324|apical plasma membrane;","GO:0003674|molecular_function;GO:0005179|hormone activity;GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000019177",9,0.747239945,95,6.111391628,0.122270015,-3.031857451,{"v":7.13791e-16,"d":"7.14E-16"},{"v":2.17647E-15,"d":"2.18E-15"},"down","yes","Psd2","protein_coding","chr18:27565587-27616672:+","gi|564393056|ref|XP_006254639.1|",3334,0,"PREDICTED: PH and SEC7 domain-containing protein 2 isoform X1 [Rattus norvegicus]","gi|672083033|ref|XM_006254577.2|",4392,0,"PREDICTED: Rattus norvegicus pleckstrin and Sec7 domain containing 2 (Psd2), transcript variant X1, mRNA","Q6P1I6",1170,0,"PH and SEC7 domain-containing protein 2","YDR170c",95.1,{"v":1e-18,"d":"1.00E-18"},"COG5307","pfam01369","Sec7","Sec7 domain. The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.","GO:0032012|regulation of ARF protein signal transduction;GO:0050790|regulation of catalytic activity;","GO:0030425|dendrite;GO:0032154|cleavage furrow;GO:0032587|ruffle membrane;GO:0043025|neuronal cell body;GO:0098794|postsynapse;GO:0098978|glutamatergic synapse;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0005543|phospholipid binding;","K12494","PSD; PH and SEC7 domain-containing protein"]
["ENSRNOG00000055142",27,2.241719834,146,9.392243975,0.238677769,-2.066863901,{"v":7.65327E-16,"d":"7.65E-16"},{"v":2.32917e-15,"d":"2.33E-15"},"down","yes","Ect2l","protein_coding","chr1:12778922-12855449:-","gi|564295993|ref|XP_006222887.1|",4356,0,"PREDICTED: epithelial cell-transforming sequence 2 oncogene-like isoform X3 [Rattus norvegicus]","gi|672012470|ref|XM_006222829.2|",1411,0,"PREDICTED: Rattus norvegicus epithelial cell transforming 2 like (Ect2l), transcript variant X7, mRNA","Q008S8",1190,0,"Epithelial cell-transforming sequence 2 oncogene-like",".",".",".",".","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0050790|regulation of catalytic activity;",".","GO:0005085|guanyl-nucleotide exchange factor activity;",".","."]
["ENSRNOG00000016696",132,10.95951919,366,23.54494038,0.46547237,-1.103232563,{"v":8.32856e-16,"d":"8.33E-16"},{"v":2.52627e-15,"d":"2.53E-15"},"down","yes","Angpt2","protein_coding","chr16:71088364-71138804:+","gi|198278529|ref|NP_604449.1|",2672,0,"angiopoietin-2 precursor [Rattus norvegicus]","gi|198278528|ref|NM_134454.1|",2269,0,"Rattus norvegicus angiopoietin 2 (Angpt2), mRNA","O35462",1033,0,"Angiopoietin-2",".",".",".",".","pfam00147","Fibrinogen_C","Fibrinogen beta and gamma chains, C-terminal globular domain.","GO:0001525|angiogenesis;GO:0001666|response to hypoxia;GO:0007281|germ cell development;GO:0009314|response to radiation;GO:0009612|response to mechanical stimulus;GO:0009749|response to glucose;GO:0010467|gene expression;GO:0010812|negative regulation of cell-substrate adhesion;GO:0014070|response to organic cyclic compound;GO:0014823|response to activity;GO:0016525|negative regulation of angiogenesis;GO:0031100|animal organ regeneration;GO:0043537|negative regulation of blood vessel endothelial cell migration;GO:0045766|positive regulation of angiogenesis;GO:0048014|Tie signaling pathway;GO:0048514|blood vessel morphogenesis;GO:0050928|negative regulation of positive chemotaxis;GO:0060135|maternal process involved in female pregnancy;GO:0071363|cellular response to growth factor stimulus;GO:0072012|glomerulus vasculature development;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0042995|cell projection;GO:0062023|collagen-containing extracellular matrix;","GO:0003674|molecular_function;GO:0005102|signaling receptor binding;GO:0030971|receptor tyrosine kinase binding;GO:0046872|metal ion binding;","K05466","ANGPT2; angiopoietin 2"]
["ENSRNOG00000022267",79,6.559106181,259,16.66158349,0.393666435,-1.344954383,{"v":2.44978e-15,"d":"2.45E-15"},{"v":7.25864e-15,"d":"7.26E-15"},"down","yes","AABR07039334.1","protein_coding","chrX:68023294-68024825:+","gi|564322934|ref|XP_006227465.1|",1029,{"v":1E-139,"d":"1.00E-139"},"PREDICTED: polyadenylate-binding protein 1-like 2 [Rattus norvegicus]","gi|672032477|ref|XM_006227403.2|",612,0,"PREDICTED: Rattus norvegicus poly(A) binding protein, cytoplasmic 1-like 2A (Pabpc1l2a), mRNA","Q5JQF8",379,{"v":3e-133,"d":"3.00E-133"},"Polyadenylate-binding protein 1-like 2",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.",".",".",".","K13126","PABPC; polyadenylate-binding protein"]
["ENSRNOG00000007147",90,7.472399447,281,18.07685313,0.413368377,-1.274500068,{"v":2.5831e-15,"d":"2.58E-15"},{"v":7.6395e-15,"d":"7.64E-15"},"down","yes","Cyp46a1","protein_coding","chr6:127243315-127274760:+","gi|564357223|ref|XP_006240610.1|",2337,0,"PREDICTED: cholesterol 24-hydroxylase isoform X1 [Rattus norvegicus]","gi|157817886|ref|NM_001108723.1|",2458,0,"Rattus norvegicus cytochrome P450, family 46, subfamily a, polypeptide 1 (Cyp46a1), mRNA","Q9WVK8",891,0,"Cholesterol 24-hydroxylase","BH0579",144,{"v":5E-36,"d":"5.00E-36"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0006707|cholesterol catabolic process;GO:0006805|xenobiotic metabolic process;GO:0042448|progesterone metabolic process;GO:1900271|regulation of long-term synaptic potentiation;GO:1903044|protein localization to membrane raft;","GO:0005789|endoplasmic reticulum membrane;GO:0030425|dendrite;GO:0098793|presynapse;GO:0098794|postsynapse;","GO:0005506|iron ion binding;GO:0008395|steroid hydroxylase activity;GO:0020037|heme binding;GO:0033781|cholesterol 24-hydroxylase activity;","K07440","CYP46A1; cholesterol 24-hydroxylase [EC:1.14.14.25]"]
["ENSRNOG00000006037",40,3.321066421,174,11.19349624,0.296696077,-1.752942245,{"v":3.2893E-15,"d":"3.29E-15"},{"v":9.66993e-15,"d":"9.67E-15"},"down","yes","Snap25","protein_coding","chr3:124041898-124123760:+","gi|537150988|gb|ERE71496.1|",1122,{"v":4e-146,"d":"4.00E-146"},"synaptosomal-associated protein 25 [Cricetulus griseus]","gi|396080313|ref|NM_001270575.1|",2103,0,"Rattus norvegicus synaptosomal-associated protein 25 (Snap25), transcript variant 1, mRNA","P60881",398,{"v":3e-133,"d":"3.00E-133"},"Synaptosomal-associated protein 25",".",".",".",".","pfam05739","SNARE","SNARE domain. Most if not all vesicular membrane fusion events in eukaryotic cells are believed to be mediated by a conserved fusion machinery, the SNARE [soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) receptors] machinery. The SNARE domain is thought to act as a protein-protein interaction module in the assembly of a SNARE protein complex.",".",".",".",".","."]
["ENSRNOG00000070543",29,2.407773155,147,9.456574413,0.254613674,-1.973618194,{"v":4.22329E-15,"d":"4.22E-15"},{"v":1.23532E-14,"d":"1.24E-14"},"down","yes","ENSRNOG00000070543","lncRNA","chr12:4295298-4298566:-","gi|852808253|ref|XP_012892261.1|",334,{"v":3e-55,"d":"3.00E-55"},"PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC106001845 [Dipodomys ordii]","gi|27228809|gb|AC137484.2|",1941,0,"Rattus Norvegicus Strain BN/SsNHsd/MCW BAC, CH230-349A03, complete sequence","P03355",138,{"v":4e-39,"d":"4.00E-39"},"Gag-Pol polyprotein",".",".",".",".","pfam00665","rve","Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyses the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.",".",".",".",".","."]
["ENSRNOG00000051915",152,12.6200524,397,25.53918396,0.4941447,-1.016994528,{"v":4.35418e-15,"d":"4.35E-15"},{"v":1.27303e-14,"d":"1.27E-14"},"down","yes","Spred3","protein_coding","chr1:84459314-84470249:-","gi|672035712|ref|XP_008757366.1|",1134,{"v":3e-140,"d":"3.00E-140"},"PREDICTED: sprouty-related, EVH1 domain-containing protein 3 isoform X1 [Rattus norvegicus]","gi|672035715|ref|XM_008759146.1|",3500,0,"PREDICTED: Rattus norvegicus sprouty-related, EVH1 domain containing 3 (Spred3), transcript variant X3, mRNA","Q6P6N5",422,{"v":2e-134,"d":"2.00E-134"},"Sprouty-related, EVH1 domain-containing protein 3",".",".",".",".","pfam05210","Sprouty","Sprouty protein (Spry). This family consists of eukaryotic Sprouty protein homologues. Sprouty proteins have been revealed as inhibitors of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases. The sprouty gene has found to be expressed in the the brain, cochlea, nasal organs, teeth, salivary gland, lungs, digestive tract, kidneys and limb buds in mice.","GO:0010719|negative regulation of epithelial to mesenchymal transition;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0043409|negative regulation of MAPK cascade;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:1902747|negative regulation of lens fiber cell differentiation;","GO:0005886|plasma membrane;","GO:0019901|protein kinase binding;","K04703","SPRED; sprouty-related, EVH1 domain-containing protein"]
["ENSRNOG00000016102",90,7.472399447,279,17.94819225,0.416331592,-1.264195059,{"v":4.81682E-15,"d":"4.82E-15"},{"v":1.40315e-14,"d":"1.40E-14"},"down","yes","Ebf3","protein_coding","chr1:191996730-192114359:-","gi|157817660|ref|NP_001101976.1|",3120,0,"transcription factor COE3 [Rattus norvegicus]","gi|672038900|ref|XM_006230463.2|",4568,0,"PREDICTED: Rattus norvegicus early B-cell factor 3 (Ebf3), transcript variant X6, mRNA","O08791",1206,0,"Transcription factor COE3",".",".",".",".","pfam01833","TIG","IPT/TIG domain. This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0046872|metal ion binding;","K09103","EBF, COE; early B-cell factor"]
["ENSRNOG00000067598",128,10.62741255,352,22.64431424,0.469319249,-1.091358462,{"v":5.07869e-15,"d":"5.08E-15"},{"v":1.47742e-14,"d":"1.48E-14"},"down","yes","ENSRNOG00000067598","lncRNA","chr2:173499695-173508313:+",".",".",".",".","gi|354789111|gb|JN953612.1|",613,0,"Mus musculus targeted deletion, lacZ-tagged mutant allele Gpatch4:tm3(EUCOMM)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam14880","COX14","Cytochrome oxidase c assembly. COX14 plays an essential role in cytochrome oxidase assembly. The COX14 product is a low-molecular weight membrane protein of mitochondria, but it is not a subunit of cytochrome oxidase. Orthology-prediction methods have identified the vertebrate C12orf62 orthologues to be orthologues of the yeast COX14.",".",".",".",".","."]
["ENSRNOG00000027024",64,5.313706274,225,14.47434859,0.367111946,-1.445708035,{"v":6.50573e-15,"d":"6.51E-15"},{"v":1.88398E-14,"d":"1.88E-14"},"down","yes","Rgs16","protein_coding","chr13:65887530-65892857:+","gi|117606399|ref|NP_001071057.1|",947,{"v":3e-119,"d":"3.00E-119"},"regulator of G-protein signaling 16 [Rattus norvegicus]","gi|672074469|ref|XM_006250010.2|",2483,0,"PREDICTED: Rattus norvegicus regulator of G-protein signaling 16 (Rgs16), transcript variant X2, mRNA","P56700",366,{"v":1E-119,"d":"1.00E-119"},"Regulator of G-protein signaling 16",".",".",".",".","pfam00615","RGS","Regulator of G protein signaling domain. RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0009968|negative regulation of signal transduction;GO:0043547|positive regulation of GTPase activity;","GO:0005737|cytoplasm;GO:0031224|intrinsic component of membrane;GO:0045121|membrane raft;","GO:0005096|GTPase activator activity;","K16449","RGS; regulator of G-protein signaling"]
["ENSRNOG00000010555",91,7.555426108,280,18.01252269,0.419454079,-1.253415221,{"v":6.52959e-15,"d":"6.53E-15"},{"v":1.89003E-14,"d":"1.89E-14"},"down","yes","Phyhip","protein_coding","chr15:45533974-45545221:+","gi|77046155|gb|AAH30494.2|",1778,0,"Phyhip protein, partial [Mus musculus]","gi|672078624|ref|XM_008770837.1|",2776,0,"PREDICTED: Rattus norvegicus phytanoyl-CoA 2-hydroxylase interacting protein (Phyhip), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam00041","fn3","Fibronectin type III domain.","GO:0008104|protein localization;","GO:0005737|cytoplasm;","GO:1990782|protein tyrosine kinase binding;",".","."]
["ENSRNOG00000028330",28,2.324746495,143,9.19925266,0.252710365,-1.984443259,{"v":7.94377e-15,"d":"7.94E-15"},{"v":2.28799e-14,"d":"2.29E-14"},"down","yes","AABR07067600.1","protein_coding","chr9:48763742-48764305:-","gi|507572163|ref|XP_004669676.1|",367,{"v":3e-53,"d":"3.00E-53"},"PREDICTED: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [Jaculus jaculus]","gi|480359913|gb|KC660101.1|",458,0,"Rattus norvegicus BCL2/adenovirus E1B interacting protein 3 variant (Bnip3) mRNA, complete cds, alternatively spliced","O55003",154,{"v":6e-46,"d":"6.00E-46"},"BCL2/adenovirus E1B 19 kDa protein-interacting protein 3",".",".",".",".","pfam06553","BNIP3","BNIP3. This family consists of several mammalian specific BCL2/adenovirus E1B 19-kDa protein-interacting protein 3 or BNIP3 sequences. BNIP3 belongs to the Bcl-2 homology 3 (BH3)-only family, a Bcl-2-related family possessing an atypical Bcl-2 homology 3 (BH3) domain, which regulates PCD from mitochondrial sites by selective Bcl-2/Bcl-XL interactions. BNIP3 family members contain a C-terminal transmembrane domain that is required for their mitochondrial localisation, homodimerization, as well as regulation of their pro-apoptotic activities. BNIP3-mediated apoptosis has been reported to be independent of caspase activation and cytochrome c release and is characterized by early plasma membrane and mitochondrial damage, prior to the appearance of chromatin condensation or DNA fragmentation.",".",".",".",".","."]
["ENSRNOG00000066988",93,7.721479429,283,18.20551401,0.424128614,-1.237426276,{"v":8.73553e-15,"d":"8.74E-15"},{"v":2.50925e-14,"d":"2.51E-14"},"down","yes","Tbpl1","protein_coding","chr1:22778459-22803122:+","gi|564324813|ref|XP_006227783.1|",975,{"v":2e-122,"d":"2.00E-122"},"PREDICTED: TATA box-binding protein-like protein 1 isoform X1 [Rattus norvegicus]","gi|672033832|ref|XM_006227721.2|",804,0,"PREDICTED: Rattus norvegicus TBP-like 1 (Tbpl1), transcript variant X1, mRNA","Q5R7U8",337,{"v":4e-108,"d":"4.00E-108"},"TATA box-binding protein-like protein 1","SPAC29E6.08",124,{"v":2e-30,"d":"2.00E-30"},"COG2101","pfam00352","TBP","Transcription factor TFIID (or TATA-binding protein, TBP).",".",".",".",".","."]
["ENSRNOG00000042283",135,11.20859917,363,23.35194906,0.479985595,-1.058936985,{"v":8.92881e-15,"d":"8.93E-15"},{"v":2.56362e-14,"d":"2.56E-14"},"down","yes","Zfp267","protein_coding","chr2:119017285-119031900:+","gi|672015709|ref|XP_008773344.1|",4248,0,"PREDICTED: zinc finger protein 345 isoform X1 [Rattus norvegicus]","gi|672015708|ref|XM_008775122.1|",2708,0,"PREDICTED: Rattus norvegicus regulator of sex-limitation candidate 18 (Rslcan18), transcript variant X1, mRNA","Q05481",623,0,"Zinc finger protein 91",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0046872|metal ion binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSRNOG00000005853",27,2.241719834,140,9.006261346,0.248906816,-2.006322359,{"v":9.79481e-15,"d":"9.79E-15"},{"v":2.80596e-14,"d":"2.81E-14"},"down","yes","Tacr1","protein_coding","chr4:114920844-115089733:+","gi|6981628|ref|NP_036799.1|",2031,0,"substance-P receptor [Rattus norvegicus]","gi|155369728|ref|NM_012667.2|",3383,0,"Rattus norvegicus tachykinin receptor 1 (Tacr1), mRNA","P14600",781,0,"Substance-P receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0002118|aggressive behavior;GO:0002526|acute inflammatory response;GO:0002687|positive regulation of leukocyte migration;GO:0003051|angiotensin-mediated drinking behavior;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007217|tachykinin receptor signaling pathway;GO:0007218|neuropeptide signaling pathway;GO:0007611|learning or memory;GO:0007616|long-term memory;GO:0008217|regulation of blood pressure;GO:0008306|associative learning;GO:0009408|response to heat;GO:0009725|response to hormone;GO:0010193|response to ozone;GO:0010634|positive regulation of epithelial cell migration;GO:0010996|response to auditory stimulus;GO:0014070|response to organic cyclic compound;GO:0014910|regulation of smooth muscle cell migration;GO:0019233|sensory perception of pain;GO:0032224|positive regulation of synaptic transmission, cholinergic;GO:0032230|positive regulation of synaptic transmission, GABAergic;GO:0032355|response to estradiol;GO:0032570|response to progesterone;GO:0035094|response to nicotine;GO:0035106|operant conditioning;GO:0035815|positive regulation of renal sodium excretion;GO:0042713|sperm ejaculation;GO:0042755|eating behavior;GO:0043117|positive regulation of vascular permeability;GO:0043278|response to morphine;GO:0045471|response to ethanol;GO:0045760|positive regulation of action potential;GO:0045777|positive regulation of blood pressure;GO:0045778|positive regulation of ossification;GO:0045907|positive regulation of vasoconstriction;GO:0046878|positive regulation of saliva secretion;GO:0046887|positive regulation of hormone secretion;GO:0048265|response to pain;GO:0048266|behavioral response to pain;GO:0048660|regulation of smooth muscle cell proliferation;GO:0050671|positive regulation of lymphocyte proliferation;GO:0050679|positive regulation of epithelial cell proliferation;GO:0051496|positive regulation of stress fiber assembly;GO:0051602|response to electrical stimulus;GO:0060083|smooth muscle contraction involved in micturition;GO:0070472|regulation of uterine smooth muscle contraction;GO:0070474|positive regulation of uterine smooth muscle contraction;GO:1902093|positive regulation of flagellated sperm motility;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0036126|sperm flagellum;GO:0044297|cell body;GO:0061827|sperm head;GO:0071944|cell periphery;GO:0097225|sperm midpiece;","GO:0004995|tachykinin receptor activity;GO:0016496|substance P receptor activity;","K04222","TACR1; tachykinin receptor 1"]
["ENSRNOG00000070376",24,1.992639853,132,8.49161784,0.234659624,-2.091358462,{"v":1.15025e-14,"d":"1.15E-14"},{"v":3.27902E-14,"d":"3.28E-14"},"down","yes","ENSRNOG00000070376","lncRNA","chr19:19550144-19608206:-","gi|149032645|gb|EDL87515.1|",161,{"v":7e-10,"d":"7.00E-10"},"rCG44317, partial [Rattus norvegicus]","gi|672084529|ref|XR_597164.1|",6658,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102550863 (LOC102550863), transcript variant X3, ncRNA",".",".",".",".",".",".",".",".","pfam14972","Mito_morph_reg","Mitochondrial morphogenesis regulator. This family of proteins regulate mitochondrial morphogenesis via a mechanism which is independent of mitofusins and dynamin-related protein 1.",".",".",".",".","."]
["ENSRNOG00000013938",125,10.37833257,343,22.0653403,0.470345457,-1.088207325,{"v":1.29653e-14,"d":"1.30E-14"},{"v":3.67959e-14,"d":"3.68E-14"},"down","yes","Tshz3","protein_coding","chr1:89381858-89460874:+","gi|564327667|ref|XP_006228955.1|",4785,0,"PREDICTED: teashirt homolog 3 isoform X1 [Rattus norvegicus]","gi|564327666|ref|XM_006228893.1|",4917,0,"PREDICTED: Rattus norvegicus teashirt zinc finger homeobox 3 (Tshz3), transcript variant X1, mRNA","D3ZKB9",1847,0,"Teashirt homolog 3",".",".",".",".","pfam03157","Glutenin_hmw","High molecular weight glutenin subunit. Members of this family include high molecular weight subunits of glutenin. This group of gluten proteins is thought to be largely responsible for the elastic properties of gluten, and hence, doughs. Indeed, glutenin high molecular weight subunits are classified as elastomeric proteins, because the glutenin network can withstand significant deformations without breaking, and return to the original conformation when the stress is removed. Elastomeric proteins differ considerably in amino acid sequence, but they are all polymers whose subunits consist of elastomeric domains, composed of repeated motifs, and non-elastic domains that mediate cross-linking between the subunits. The elastomeric domain motifs are all rich in glycine residues in addition to other hydrophobic residues. High molecular weight glutenin subunits have an extensive central elastomeric domain, flanked by two terminal non-elastic domains that form disulphide cross-links. The central elastomeric domain is characterized by the following three repeated motifs: PGQGQQ, GYYPTS[P/L]QQ, GQQ. It possesses overlapping beta-turns within and between the repeated motifs, and assumes a regular helical secondary structure with a diameter of approx. 1.9 nm and a pitch of approx. 1.5 nm.","GO:0001656|metanephros development;GO:0001657|ureteric bud development;GO:0001701|in utero embryonic development;GO:0002087|regulation of respiratory gaseous exchange by neurological system process;GO:0006357|regulation of transcription by RNA polymerase II;GO:0030324|lung development;GO:0045892|negative regulation of transcription, DNA-templated;GO:0048745|smooth muscle tissue development;GO:0050881|musculoskeletal movement;GO:0050975|sensory perception of touch;GO:0051152|positive regulation of smooth muscle cell differentiation;GO:0051968|positive regulation of synaptic transmission, glutamatergic;GO:0060291|long-term synaptic potentiation;GO:0060993|kidney morphogenesis;GO:0072105|ureteric peristalsis;GO:0072193|ureter smooth muscle cell differentiation;GO:0072195|kidney smooth muscle cell differentiation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0030426|growth cone;","GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0005515|protein binding;GO:0046872|metal ion binding;","K09236","TSHZ; teashirt"]
["ENSRNOG00000000281",117,9.714119281,327,21.03605329,0.461784307,-1.11470895,{"v":1.69058E-14,"d":"1.69E-14"},{"v":4.77673e-14,"d":"4.78E-14"},"down","yes","Prodh1","protein_coding","chr11:82910137-82927305:+","gi|564377641|ref|XP_006248705.1|",2823,0,"PREDICTED: proline dehydrogenase 1, mitochondrial isoform X2 [Rattus norvegicus]","gi|564377640|ref|XM_006248643.1|",2121,0,"PREDICTED: Rattus norvegicus proline dehydrogenase (oxidase) 1 (Prodh), transcript variant X2, mRNA","Q9WU79",1004,0,"Proline dehydrogenase 1, mitochondrial","SPCC70.03c",118,{"v":3e-27,"d":"3.00E-27"},"COG0506","pfam01619","Pro_dh","Proline dehydrogenase.","GO:0010133|proline catabolic process to glutamate;GO:0010942|positive regulation of cell death;","GO:0005654|nucleoplasm;GO:0005739|mitochondrion;GO:0043231|intracellular membrane-bounded organelle;","GO:0004657|proline dehydrogenase activity;GO:0016597|amino acid binding;GO:0071949|FAD binding;","K00318","PRODH, fadM, putB; proline dehydrogenase [EC:1.5.5.2]"]
["ENSRNOG00000052157",48,3.985279705,187,12.02979194,0.331284176,-1.593858803,{"v":2.26268e-14,"d":"2.26E-14"},{"v":6.35668e-14,"d":"6.36E-14"},"down","yes","Nav3","protein_coding","chr7:45054296-45840698:-","gi|124486648|ref|NP_001074504.1|",9485,0,"neuron navigator 3 [Mus musculus]","gi|300796330|ref|NM_001191782.1|",6641,0,"Rattus norvegicus neuron navigator 3 (Nav3), mRNA","Q80TN7",3638,0,"Neuron navigator 3","ECU09g0290",71.6,{"v":2e-11,"d":"2.00E-11"},"COG5069","pfam00307","CH","Calponin homology (CH) domain. The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.","GO:0007026|negative regulation of microtubule depolymerization;GO:0022008|neurogenesis;GO:0030336|negative regulation of cell migration;GO:0031116|positive regulation of microtubule polymerization;GO:0032703|negative regulation of interleukin-2 production;","GO:0005634|nucleus;GO:0005635|nuclear envelope;GO:1990752|microtubule end;","GO:0005524|ATP binding;GO:0008017|microtubule binding;","K23919","NAV3; neuron navigator 3"]
["ENSRNOG00000021441",77,6.39305286,248,15.95394867,0.400719157,-1.319336614,{"v":2.30274e-14,"d":"2.30E-14"},{"v":6.46637e-14,"d":"6.47E-14"},"down","yes","Reln","protein_coding","chr4:12736130-13162211:+","gi|149046582|gb|EDL99407.1|",18132,0,"reelin [Rattus norvegicus]","gi|17221617|dbj|AB049473.1|",10563,0,"Rattus norvegicus mRNA for reelin, complete cds","P58751",6975,0,"Reelin",".",".",".",".","pfam02014","Reeler","Reeler domain.","GO:0000904|cell morphogenesis involved in differentiation;GO:0001764|neuron migration;GO:0006508|proteolysis;GO:0007155|cell adhesion;GO:0007411|axon guidance;GO:0007417|central nervous system development;GO:0007420|brain development;GO:0007494|midgut development;GO:0007612|learning;GO:0007613|memory;GO:0007616|long-term memory;GO:0007626|locomotory behavior;GO:0008306|associative learning;GO:0009410|response to xenobiotic stimulus;GO:0009612|response to mechanical stimulus;GO:0009636|response to toxic substance;GO:0009725|response to hormone;GO:0010001|glial cell differentiation;GO:0010226|response to lithium ion;GO:0010468|regulation of gene expression;GO:0010976|positive regulation of neuron projection development;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0014070|response to organic cyclic compound;GO:0016358|dendrite development;GO:0016477|cell migration;GO:0017085|response to insecticide;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0021511|spinal cord patterning;GO:0021517|ventral spinal cord development;GO:0021542|dentate gyrus development;GO:0021766|hippocampus development;GO:0021769|orbitofrontal cortex development;GO:0021800|cerebral cortex tangential migration;GO:0021819|layer formation in cerebral cortex;GO:0021854|hypothalamus development;GO:0021987|cerebral cortex development;GO:0030900|forebrain development;GO:0032008|positive regulation of TOR signaling;GO:0032570|response to progesterone;GO:0032793|positive regulation of CREB transcription factor activity;GO:0035176|social behavior;GO:0035418|protein localization to synapse;GO:0038026|reelin-mediated signaling pathway;GO:0042403|thyroid hormone metabolic process;GO:0043200|response to amino acid;GO:0045471|response to ethanol;GO:0045860|positive regulation of protein kinase activity;GO:0048265|response to pain;GO:0048678|response to axon injury;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050795|regulation of behavior;GO:0050804|modulation of chemical synaptic transmission;GO:0051057|positive regulation of small GTPase mediated signal transduction;GO:0051412|response to corticosterone;GO:0051602|response to electrical stimulus;GO:0051968|positive regulation of synaptic transmission, glutamatergic;GO:0060291|long-term synaptic potentiation;GO:0061003|positive regulation of dendritic spine morphogenesis;GO:0061098|positive regulation of protein tyrosine kinase activity;GO:0070542|response to fatty acid;GO:0071549|cellular response to dexamethasone stimulus;GO:0090129|positive regulation of synapse maturation;GO:0097114|NMDA glutamate receptor clustering;GO:0097119|postsynaptic density protein 95 clustering;GO:0097120|receptor localization to synapse;GO:0097477|lateral motor column neuron migration;GO:1900273|positive regulation of long-term synaptic potentiation;GO:1902078|positive regulation of lateral motor column neuron migration;GO:2000310|regulation of NMDA receptor activity;GO:2000463|positive regulation of excitatory postsynaptic potential;GO:2000969|positive regulation of AMPA receptor activity;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0031012|extracellular matrix;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043204|perikaryon;","GO:0003674|molecular_function;GO:0008236|serine-type peptidase activity;GO:0016787|hydrolase activity;GO:0046872|metal ion binding;GO:0070325|lipoprotein particle receptor binding;GO:0070326|very-low-density lipoprotein particle receptor binding;","K06249","RELN; reelin [EC:3.4.21.-]"]
["ENSRNOG00000008489",49,4.068306366,189,12.15845282,0.334607242,-1.579459424,{"v":2.43799e-14,"d":"2.44E-14"},{"v":6.82818e-14,"d":"6.83E-14"},"down","yes","Ppih","protein_coding","chr5:132906328-132924267:-","gi|148698503|gb|EDL30450.1|",946,{"v":1e-124,"d":"1.00E-124"},"mCG4207, isoform CRA_b, partial [Mus musculus]","gi|672019868|ref|XM_006225500.2|",1189,0,"PREDICTED: Rattus norvegicus peptidylprolyl isomerase H (cyclophilin H) (Ppih), transcript variant X3, mRNA","O43447",364,{"v":1e-124,"d":"1.00E-124"},"Peptidyl-prolyl cis-trans isomerase H","SPBC1709.04c",219,{"v":1e-68,"d":"1.00E-68"},"COG0652","pfam00160","Pro_isomerase","Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD. The peptidyl-prolyl cis-trans isomerases, also known as cyclophilins, share this domain of about 109 amino acids. Cyclophilins have been found in all organisms studied so far and catalyse peptidyl-prolyl isomerization during which the peptide bond preceding proline (the peptidyl-prolyl bond) is stabilized in the cis conformation. Mammalian cyclophilin A (CypA) is a major cellular target for the immunosuppressive drug cyclosporin A (CsA). Other roles for cyclophilins may include chaperone and cell signalling function.","GO:0000413|protein peptidyl-prolyl isomerization;GO:0006457|protein folding;GO:0008150|biological_process;GO:0045070|positive regulation of viral genome replication;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0016607|nuclear speck;GO:0043231|intracellular membrane-bounded organelle;GO:0046540|U4/U6 x U5 tri-snRNP complex;GO:0071001|U4/U6 snRNP;","GO:0003674|molecular_function;GO:0003755|peptidyl-prolyl cis-trans isomerase activity;GO:0016018|cyclosporin A binding;GO:0043021|ribonucleoprotein complex binding;","K09567","PPIH, CYPH; peptidyl-prolyl isomerase H (cyclophilin H) [EC:5.2.1.8]"]
["ENSRNOG00000037206",143,11.87281246,373,23.99525344,0.494798377,-1.015087327,{"v":3.15662e-14,"d":"3.16E-14"},{"v":8.78318e-14,"d":"8.78E-14"},"down","yes","Ccdc77","protein_coding","chr4:153534187-153566545:-","gi|564348683|ref|XP_006237298.1|",2763,0,"PREDICTED: coiled-coil domain-containing protein 77 isoform X2 [Rattus norvegicus]","gi|672050858|ref|XM_006237236.2|",2685,0,"PREDICTED: Rattus norvegicus coiled-coil domain containing 77 (Ccdc77), transcript variant X1, mRNA","Q9CZH8",757,0,"Coiled-coil domain-containing protein 77",".",".",".",".","pfam02375","JmjN","jmjN domain.",".","GO:0005813|centrosome;",".","K16757","CCDC77; coiled-coil domain-containing protein 77"]
["ENSRNOG00000056550",103,8.551746034,298,19.17047058,0.446089521,-1.164594837,{"v":3.29903e-14,"d":"3.30E-14"},{"v":9.16748e-14,"d":"9.17E-14"},"down","yes","Epb41l4b","protein_coding","chr5:71694331-71851990:-","gi|568927034|ref|XP_006538150.1|",4158,0,"PREDICTED: band 4.1-like protein 4B isoform X2 [Mus musculus]","gi|755506619|ref|XM_006538087.2|",3166,0,"PREDICTED: Mus musculus erythrocyte protein band 4.1-like 4b (Epb4.1l4b), transcript variant X2, mRNA","Q9H329",1505,0,"Band 4.1-like protein 4B",".",".",".",".","pfam09380","FERM_C","FERM C-terminal PH-like domain.","GO:0010628|positive regulation of gene expression;GO:0031032|actomyosin structure organization;GO:0042060|wound healing;GO:0045785|positive regulation of cell adhesion;GO:0051549|positive regulation of keratinocyte migration;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0005923|bicellular tight junction;GO:0045177|apical part of cell;","GO:0008092|cytoskeletal protein binding;","K21111","EPB41L4B, EHM2, LULU2; band 4.1-like protein 4B"]
["ENSRNOG00000062541",69,5.728839576,230,14.79600078,0.38718838,-1.368892438,{"v":3.99512e-14,"d":"4.00E-14"},{"v":1.10156E-13,"d":"1.10E-13"},"down","yes","ENSRNOG00000062541","protein_coding","chr4:29310091-29312643:+","gi|532030848|ref|XP_005358366.1|",2841,0,"PREDICTED: frizzled-1 [Microtus ochrogaster]","gi|158186717|ref|NM_021266.3|",1656,0,"Rattus norvegicus frizzled class receptor 1 (Fzd1), mRNA","Q9UP38",1087,0,"Frizzled-1",".",".",".",".","pfam01534","Frizzled","Frizzled/Smoothened family membrane region. This family contains the membrane spanning region of frizzled and smoothened receptors. This membrane region is predicted to contain seven transmembrane alpha helices. Proteins related to Drosophila frizzled are receptors for Wnt (mediating the beta-catenin signalling pathway), but also the planar cell polarity (PCP) pathway and the Wnt/calcium pathway. The predominantly alpha-helical Cys-rich ligand-binding region (CRD) of Frizzled is both necessary and sufficient for Wnt binding. The smoothened receptor mediates hedgehog signalling.",".",".",".",".","."]
["ENSRNOG00000028616",10,0.830266605,90,5.789739437,0.143403104,-2.801851845,{"v":4.27666e-14,"d":"4.28E-14"},{"v":1.17817e-13,"d":"1.18E-13"},"down","yes","Pck1","protein_coding","chr3:161930256-161936191:+","gi|158430173|pdb|2QF2|A",3273,0,"Chain A, Rat Cytosolic Pepck In Complex With Oxaloacetic Acid And Gdp.","gi|61835220|ref|NM_198780.3|",2621,0,"Rattus norvegicus phosphoenolpyruvate carboxykinase 1 (Pck1), mRNA","P07379",1264,0,"Phosphoenolpyruvate carboxykinase, cytosolic [GTP]","CPn0851",622,0,"COG1274","pfam00821","PEPCK","Phosphoenolpyruvate carboxykinase. Catalyses the formation of phosphoenolpyruvate by decarboxylation of oxaloacetate.","GO:0006006|glucose metabolic process;GO:0006094|gluconeogenesis;GO:0006107|oxaloacetate metabolic process;GO:0006165|nucleoside diphosphate phosphorylation;GO:0006629|lipid metabolic process;GO:0007568|aging;GO:0009617|response to bacterium;GO:0014823|response to activity;GO:0018105|peptidyl-serine phosphorylation;GO:0019543|propionate catabolic process;GO:0032496|response to lipopolysaccharide;GO:0032868|response to insulin;GO:0032869|cellular response to insulin stimulus;GO:0033993|response to lipid;GO:0042593|glucose homeostasis;GO:0042594|response to starvation;GO:0043382|positive regulation of memory T cell differentiation;GO:0046327|glycerol biosynthetic process from pyruvate;GO:0046890|regulation of lipid biosynthetic process;GO:0051365|cellular response to potassium ion starvation;GO:0061402|positive regulation of transcription from RNA polymerase II promoter in response to acidic pH;GO:0070365|hepatocyte differentiation;GO:0070741|response to interleukin-6;GO:0071300|cellular response to retinoic acid;GO:0071320|cellular response to cAMP;GO:0071332|cellular response to fructose stimulus;GO:0071333|cellular response to glucose stimulus;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071377|cellular response to glucagon stimulus;GO:0071456|cellular response to hypoxia;GO:0071549|cellular response to dexamethasone stimulus;GO:1904640|response to methionine;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;","GO:0000287|magnesium ion binding;GO:0004550|nucleoside diphosphate kinase activity;GO:0004611|phosphoenolpyruvate carboxykinase activity;GO:0004613|phosphoenolpyruvate carboxykinase (GTP) activity;GO:0005525|GTP binding;GO:0019003|GDP binding;GO:0030145|manganese ion binding;GO:0031406|carboxylic acid binding;","K01596","E4.1.1.32, pckA, PCK; phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32]"]
["ENSRNOG00000022321",79,6.559106181,250,16.08260955,0.407838427,-1.29393038,{"v":4.39318E-14,"d":"4.39E-14"},{"v":1.20819e-13,"d":"1.21E-13"},"down","yes","Hapln3","protein_coding","chr1:133046467-133080177:-","gi|564328981|ref|XP_006229459.1|",2541,0,"PREDICTED: hyaluronan and proteoglycan link protein 3 isoform X1 [Rattus norvegicus]","gi|672037089|ref|XM_006229397.2|",2194,0,"PREDICTED: Rattus norvegicus hyaluronan and proteoglycan link protein 3 (Hapln3), transcript variant X1, mRNA","P70490",860,0,"Lactadherin",".",".",".",".","pfam00193","Xlink","Extracellular link domain.","GO:0001501|skeletal system development;GO:0007155|cell adhesion;GO:0007417|central nervous system development;","GO:0005576|extracellular region;GO:0031012|extracellular matrix;","GO:0005540|hyaluronic acid binding;","K06852","HAPLN3; hyaluronan and proteoglycan link protein 3"]
["ENSRNOG00000008480",65,5.396732934,220,14.1526964,0.38132189,-1.390918744,{"v":7.13752e-14,"d":"7.14E-14"},{"v":1.9437e-13,"d":"1.94E-13"},"down","yes","Kcnab3","protein_coding","chr10:54047825-54054174:+","gi|13928902|ref|NP_113840.1|",1832,0,"voltage-gated potassium channel subunit beta-3 [Rattus norvegicus]","gi|672068038|ref|XM_008767862.1|",2105,0,"PREDICTED: Rattus norvegicus potassium voltage-gated channel, shaker-related subfamily, beta member 3 (Kcnab3), transcript variant X1, mRNA","Q63494",710,0,"Voltage-gated potassium channel subunit beta-3","TM0313",278,{"v":8e-86,"d":"8.00E-86"},"COG0667","pfam00248","Aldo_ket_red","Aldo/keto reductase family. This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.","GO:0071805|potassium ion transmembrane transport;GO:1901379|regulation of potassium ion transmembrane transport;","GO:0005737|cytoplasm;GO:0008076|voltage-gated potassium channel complex;","GO:0004033|aldo-keto reductase (NADP) activity;GO:0005249|voltage-gated potassium channel activity;GO:0015459|potassium channel regulator activity;GO:0044325|ion channel binding;GO:0047834|D-threo-aldose 1-dehydrogenase activity;","K04884","KCNAB3; potassium voltage-gated channel Shaker-related subfamily A, beta member 3"]
["ENSRNOG00000047653",50,4.151333026,188,12.09412238,0.34325211,-1.542659506,{"v":7.70538e-14,"d":"7.71E-14"},{"v":2.09566E-13,"d":"2.10E-13"},"down","yes","Crybb1","protein_coding","chr12:44369735-44383344:-","gi|568935244|ref|XP_006534815.1|",1039,{"v":3e-137,"d":"3.00E-137"},"PREDICTED: beta-crystallin B1 isoform X2 [Mus musculus]","gi|162287072|ref|NM_012936.2|",979,0,"Rattus norvegicus crystallin, beta B1 (Crybb1), mRNA","Q9WVJ5",391,{"v":3e-135,"d":"3.00E-135"},"Beta-crystallin B1",".",".",".",".","pfam00030","Crystall","Beta/Gamma crystallin. The alignment comprises two Greek key motifs since the similarity between them is very low.","GO:0002088|lens development in camera-type eye;GO:0007601|visual perception;",".","GO:0005212|structural constituent of eye lens;","K23482","CRYB; beta-crystallin"]
["ENSRNOG00000049056",109,9.049905997,306,19.68511408,0.45973348,-1.121130362,{"v":8.90429E-14,"d":"8.90E-14"},{"v":2.41557e-13,"d":"2.42E-13"},"down","yes","AABR07051450.1","protein_coding","chr3:15912485-15923041:+","gi|830005084|ref|XP_004677358.2|",954,{"v":2E-121,"d":"2.00E-121"},"PREDICTED: adenylate kinase isoenzyme 1 isoform X1 [Condylura cristata]","gi|467091434|ref|NM_024349.3|",1974,0,"Rattus norvegicus adenylate kinase 1 (Ak1), mRNA","P39069",366,{"v":3e-121,"d":"3.00E-121"},"Adenylate kinase isoenzyme 1","YKL024c",157,{"v":5e-43,"d":"5.00E-43"},"COG0563","pfam00406","ADK","Adenylate kinase.",".",".",".",".","."]
["ENSRNOG00000023496",1,0.083026661,58,3.731165415,0.022252206,-5.489907839,{"v":8.93195e-14,"d":"8.93E-14"},{"v":2.42204E-13,"d":"2.42E-13"},"down","yes","Fam189a1","protein_coding","chr1:118288379-118700671:-","gi|166795260|ref|NP_898910.2|",2266,0,"protein FAM189A1 [Mus musculus]","gi|166795259|ref|NM_183087.4|",3018,0,"Mus musculus family with sequence similarity 189, member A1 (Fam189a1), mRNA","Q6A044",877,0,"Protein FAM189A1",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000019208",128,10.62741255,339,21.80801854,0.487316742,-1.037068307,{"v":1.75738E-13,"d":"1.76E-13"},{"v":4.67035e-13,"d":"4.67E-13"},"down","yes","P2rx5","protein_coding","chr10:57777819-57789423:+","gi|149053319|gb|EDM05136.1|",2314,0,"purinergic receptor P2X, ligand-gated ion channel, 5 [Rattus norvegicus]","gi|31377507|ref|NM_080780.2|",2387,0,"Rattus norvegicus purinergic receptor P2X 5 (P2rx5), mRNA","P51578",893,0,"P2X purinoceptor 5",".",".",".",".","pfam00864","P2X_receptor","ATP P2X receptor.","GO:0006812|cation transport;GO:0009268|response to pH;GO:0010043|response to zinc ion;GO:0033198|response to ATP;GO:0035590|purinergic nucleotide receptor signaling pathway;GO:0043416|regulation of skeletal muscle tissue regeneration;GO:0048630|skeletal muscle tissue growth;GO:0051592|response to calcium ion;GO:0060079|excitatory postsynaptic potential;GO:0098655|cation transmembrane transport;GO:1905665|positive regulation of calcium ion import across plasma membrane;","GO:0005639|integral component of nuclear inner membrane;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0098794|postsynapse;","GO:0001614|purinergic nucleotide receptor activity;GO:0004931|extracellularly ATP-gated cation channel activity;GO:0005244|voltage-gated ion channel activity;GO:0005524|ATP binding;GO:0042802|identical protein binding;","K05219","P2RX5; P2X purinoceptor 5"]
["ENSRNOG00000008336",89,7.389372787,265,17.04756612,0.433456174,-1.206041962,{"v":1.90598E-13,"d":"1.91E-13"},{"v":5.05475e-13,"d":"5.05E-13"},"down","yes","Tnfrsf11b","protein_coding","chr7:85566520-85594538:-","gi|6981306|ref|NP_037002.1|",2094,0,"tumor necrosis factor receptor superfamily member 11B precursor [Rattus norvegicus]","gi|52138596|ref|NM_012870.2|",2106,0,"Rattus norvegicus tumor necrosis factor receptor superfamily, member 11b (Tnfrsf11b), mRNA","O08727",811,0,"Tumor necrosis factor receptor superfamily member 11B",".",".",".",".","pfam00531","Death","Death domain.","GO:0006915|apoptotic process;GO:0007165|signal transduction;GO:0007584|response to nutrient;GO:0009410|response to xenobiotic stimulus;GO:0010035|response to inorganic substance;GO:0030198|extracellular matrix organization;GO:0032026|response to magnesium ion;GO:0042489|negative regulation of odontogenesis of dentin-containing tooth;GO:0043627|response to estrogen;GO:0045779|negative regulation of bone resorption;GO:0046685|response to arsenic-containing substance;","GO:0005615|extracellular space;GO:0031012|extracellular matrix;","GO:0003674|molecular_function;GO:0005125|cytokine activity;","K05148","TNFRSF11B, OPG; tumor necrosis factor receptor superfamily member 11B"]
["ENSRNOG00000060849",76,6.3100262,239,15.37497473,0.410408883,-1.284866138,{"v":2.12536e-13,"d":"2.13E-13"},{"v":5.62957e-13,"d":"5.63E-13"},"down","yes","Rcor2","protein_coding","chr1:204454360-204460838:+","gi|672039306|ref|XP_008758335.1|",2143,0,"PREDICTED: REST corepressor 2 isoform X2 [Rattus norvegicus]","gi|62078716|ref|NM_001013994.1|",2434,0,"Rattus norvegicus REST corepressor 2 (Rcor2), mRNA","Q5FWT8",804,0,"REST corepressor 2",".",".",".",".","pfam01448","ELM2","ELM2 domain. The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in a member from Arabidopsis thaliana. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0016575|histone deacetylation;GO:0045892|negative regulation of transcription, DNA-templated;","GO:0000118|histone deacetylase complex;GO:0000785|chromatin;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0003714|transcription corepressor activity;GO:0005515|protein binding;GO:0019899|enzyme binding;",".","."]
["ENSRNOG00000018254",57,4.73251965,199,12.8017572,0.369677348,-1.43566145,{"v":3.06855e-13,"d":"3.07E-13"},{"v":8.04784e-13,"d":"8.05E-13"},"down","yes","Sncaip","protein_coding","chr18:46207152-46343929:+","gi|157817380|ref|NP_001100849.1|",4612,0,"synphilin-1 [Rattus norvegicus]","gi|157817379|ref|NM_001107379.1|",3803,0,"Rattus norvegicus synuclein, alpha interacting protein (Sncaip), mRNA","Q99ME3",1656,0,"Synphilin-1","Ta0196",53.9,5e-07,"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0008219|cell death;GO:0042417|dopamine metabolic process;GO:0046928|regulation of neurotransmitter secretion;GO:0090083|regulation of inclusion body assembly;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0036464|cytoplasmic ribonucleoprotein granule;","GO:0031625|ubiquitin protein ligase binding;GO:0042802|identical protein binding;","K04558","SNCAIP; synphilin-1"]
["ENSRNOG00000059163",134,11.12557251,347,22.32266205,0.498398107,-1.004629506,{"v":3.8691e-13,"d":"3.87E-13"},{"v":1.00936e-12,"d":"1.01E-12"},"down","yes","AABR07069454.1","protein_coding","chr8:20696311-20702855:+","gi|564309661|ref|XP_006226388.1|",2101,0,"PREDICTED: zinc finger protein 439 isoform X1 [Rattus norvegicus]","gi|564309660|ref|XM_006226326.1|",3139,0,"PREDICTED: Rattus norvegicus zinc finger protein 564-like (LOC102547901), transcript variant X1, mRNA","Q8TBZ8",385,{"v":2E-118,"d":"2.00E-118"},"Zinc finger protein 564",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000068418",78,6.476079521,241,15.5036356,0.417713605,-1.259413961,{"v":3.95089e-13,"d":"3.95E-13"},{"v":1.02944e-12,"d":"1.03E-12"},"down","yes","Gbp6","protein_coding","chr14:4730453-4839062:+","gi|190194427|ref|NP_001121783.1|",3241,0,"ATP-binding cassette, subfamily G (WHITE), member 3 [Rattus norvegicus]","gi|190194426|ref|NM_001128311.1|",2270,0,"Rattus norvegicus ATP-binding cassette, subfamily G (WHITE), member 3 (Abcg3), mRNA","Q99P81",1022,0,"ATP-binding cassette sub-family G member 3","SPCC18B5.01c_2",128,{"v":5e-30,"d":"5.00E-30"},"COG1131","pfam02263","GBP","Guanylate-binding protein, N-terminal domain. Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.",".",".",".",".","."]
["ENSRNOG00000003510",133,11.04254585,345,22.19400117,0.497546421,-1.00709696,{"v":4.05275e-13,"d":"4.05E-13"},{"v":1.05512e-12,"d":"1.06E-12"},"down","yes","Fmo2","protein_coding","chr13:75224402-75244308:-","gi|78214354|ref|NP_653338.2|",2873,0,"dimethylaniline monooxygenase [N-oxide-forming] 2 [Rattus norvegicus]","gi|78214353|ref|NM_144737.2|",2010,0,"Rattus norvegicus flavin containing monooxygenase 2 (Fmo2), mRNA","Q6IRI9",1106,0,"Dimethylaniline monooxygenase [N-oxide-forming] 2","CC0774",241,{"v":1E-70,"d":"1.00E-70"},"COG2072","pfam00743","FMO-like","Flavin-binding monooxygenase-like. This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.","GO:0006082|organic acid metabolic process;GO:0006739|NADP metabolic process;GO:0006805|xenobiotic metabolic process;GO:0009404|toxin metabolic process;GO:0070995|NADPH oxidation;GO:0072592|oxygen metabolic process;","GO:0005789|endoplasmic reticulum membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0004497|monooxygenase activity;GO:0004499|N,N-dimethylaniline monooxygenase activity;GO:0050660|flavin adenine dinucleotide binding;GO:0050661|NADP binding;","K00485","FMO; dimethylaniline monooxygenase (N-oxide forming) / hypotaurine monooxygenase [EC:1.14.13.8 1.8.1.-]"]
["ENSRNOG00000032846",93,7.721479429,270,17.36921831,0.444549622,-1.16958363,{"v":4.30869e-13,"d":"4.31E-13"},{"v":1.12038e-12,"d":"1.12E-12"},"down","yes","Cdpf1","protein_coding","chr7:116901003-116905406:-","gi|194733721|ref|NP_001124168.1|",855,{"v":1e-110,"d":"1.00E-110"},"cysteine-rich DPF motif domain-containing protein 1 [Rattus norvegicus]","gi|564361382|ref|XM_006242163.1|",908,0,"PREDICTED: Rattus norvegicus similar to 2210021J22Rik protein (RGD1306001), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam10170","C6_DPF","Cysteine-rich domain. This is the N-terminal approximately 100 amino acids of a family of proteins found from nematodes to humans. It contains between six and eight highly conserved cysteine residues and a characteristic DPF sequence motif. One member is putatively named as receptor for egg jelly protein but this could not confirmed.",".",".",".",".","."]
["ENSRNOG00000001692",90,7.472399447,264,16.98323568,0.439986796,-1.184467867,{"v":4.58648e-13,"d":"4.59E-13"},{"v":1.19116e-12,"d":"1.19E-12"},"down","yes","Chaf1b","protein_coding","chr11:33200981-33221070:+","gi|67078530|ref|NP_001019912.1|",2789,0,"chromatin assembly factor 1 subunit B [Rattus norvegicus]","gi|67078529|ref|NM_001024741.1|",1933,0,"Rattus norvegicus chromatin assembly factor 1 subunit B (Chaf1b), mRNA","Q9D0N7",1015,0,"Chromatin assembly factor 1 subunit B",".",".",".",".","pfam15512","CAF-1_p60_C","Chromatin assembly factor complex 1 subunit p60, C-terminal. CAF-1_p60_C is a family of vertebral proteins that is involved in chromatin assembly. CAF-1_p60 is one of the three subunits of the CAF-1 complex, and this domain binds to the C-terminal region of CAF-1_p150, family pfam12253. The N-terminal part of the CAF-1_p60 proteins is a WD-repeat structure, pfam00400.","GO:0006334|nucleosome assembly;GO:0006335|DNA replication-dependent nucleosome assembly;GO:0031497|chromatin assembly;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0032991|protein-containing complex;GO:0033186|CAF-1 complex;",".","K10751","CHAF1B; chromatin assembly factor 1 subunit B"]
["ENSRNOG00000019068",106,8.800826016,294,18.91314883,0.465328439,-1.103678734,{"v":5.33125e-13,"d":"5.33E-13"},{"v":1.37177e-12,"d":"1.37E-12"},"down","yes","Ctrb1","protein_coding","chr19:39652933-39657688:-","gi|6978717|ref|NP_036668.1|",1278,{"v":2E-175,"d":"2.00E-175"},"chymotrypsinogen B precursor [Rattus norvegicus]","gi|298893397|emb|FQ234339.1|",795,0,"Rattus norvegicus TL0AEA59YF09 mRNA sequence","P07338",496,{"v":6e-177,"d":"6.00E-177"},"Chymotrypsinogen B","VC1649",105,{"v":2e-24,"d":"2.00E-24"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;GO:0007584|response to nutrient;GO:0007586|digestion;GO:0009636|response to toxic substance;GO:0030163|protein catabolic process;GO:0032094|response to food;GO:0034097|response to cytokine;GO:0043065|positive regulation of apoptotic process;GO:0043434|response to peptide hormone;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005764|lysosome;","GO:0004252|serine-type endopeptidase activity;GO:0005515|protein binding;GO:0008233|peptidase activity;","K01310","CTRB; chymotrypsin [EC:3.4.21.1]"]
["ENSRNOG00000019390",36,2.988959779,151,9.713896166,0.307699375,-1.700406582,{"v":6.70486e-13,"d":"6.70E-13"},{"v":1.71349E-12,"d":"1.71E-12"},"down","yes","Klhl40","protein_coding","chr8:121441287-121446800:+","gi|564366312|ref|XP_006244168.1|",3198,0,"PREDICTED: kelch-like protein 40 isoform X1 [Rattus norvegicus]","gi|672063610|ref|XM_006244106.2|",2331,0,"PREDICTED: Rattus norvegicus kelch-like family member 40 (Klhl40), transcript variant X1, mRNA","Q9D783",1222,0,"Kelch-like protein 40",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.","GO:0031397|negative regulation of protein ubiquitination;GO:0031398|positive regulation of protein ubiquitination;GO:0032435|negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032436|positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0048741|skeletal muscle fiber development;GO:0098528|skeletal muscle fiber differentiation;","GO:0005737|cytoplasm;GO:0031463|Cul3-RING ubiquitin ligase complex;GO:0031672|A band;GO:0031674|I band;",".","K10473","KBTBD5_10; kelch repeat and BTB domain-containing protein 5/10"]
["ENSRNOG00000066766",2,0.166053321,57,3.666834977,0.045285191,-4.464816858,{"v":6.98966e-13,"d":"6.99E-13"},{"v":1.78342e-12,"d":"1.78E-12"},"down","yes","ENSRNOG00000066766","protein_coding","chr14:4692271-4708839:+","gi|672027632|ref|XP_006221724.2|",2013,0,"PREDICTED: LOW QUALITY PROTEIN: guanylate-binding protein 6-like [Rattus norvegicus]","gi|672075863|ref|XM_006250610.2|",715,0,"PREDICTED: Rattus norvegicus guanylate-binding protein 6-like (LOC102554096), transcript variant X2, mRNA","Q6ZN66",523,{"v":2E-179,"d":"2.00E-179"},"Guanylate-binding protein 6",".",".",".",".","pfam02841","GBP_C","Guanylate-binding protein, C-terminal domain. Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.",".",".",".",".","."]
["ENSRNOG00000018342",106,8.800826016,293,18.84881839,0.46691659,-1.098763244,{"v":7.05736e-13,"d":"7.06E-13"},{"v":1.79998E-12,"d":"1.80E-12"},"down","yes","ENSRNOG00000018342","protein_coding","chr18:69059519-69327385:-","gi|569003943|ref|XP_006526036.1|",2823,0,"PREDICTED: CBP80/20-dependent translation initiation factor isoform X2 [Mus musculus]","gi|755560937|ref|XM_006525973.2|",1970,0,"PREDICTED: Mus musculus CBP80/20-dependent translation initiation factor (Ctif), transcript variant X3, mRNA","Q6PEE2",1089,0,"CBP80/20-dependent translation initiation factor",".",".",".",".","pfam02854","MIF4G","MIF4G domain. MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.","GO:0000184|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006446|regulation of translational initiation;GO:0045727|positive regulation of translation;","GO:0005829|cytosol;GO:0048471|perinuclear region of cytoplasm;","GO:0003723|RNA binding;GO:0008494|translation activator activity;",".","."]
["ENSRNOG00000003400",74,6.143972879,230,14.79600078,0.415245509,-1.267963529,{"v":1.02404e-12,"d":"1.02E-12"},{"v":2.57686E-12,"d":"2.58E-12"},"down","yes","Fmo4","protein_coding","chr13:75154684-75172874:-","gi|564381432|ref|XP_006250206.1|",2907,0,"PREDICTED: dimethylaniline monooxygenase [N-oxide-forming] 4 isoform X1 [Rattus norvegicus]","gi|402744366|ref|NM_144561.2|",2271,0,"Rattus norvegicus flavin containing monooxygenase 4 (Fmo4), transcript variant 2, mRNA","Q8K4B7",1124,0,"Dimethylaniline monooxygenase [N-oxide-forming] 4","CC0774",181,{"v":1e-48,"d":"1.00E-48"},"COG2072","pfam00743","FMO-like","Flavin-binding monooxygenase-like. This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.","GO:0042178|xenobiotic catabolic process;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0004497|monooxygenase activity;GO:0004499|N,N-dimethylaniline monooxygenase activity;GO:0050660|flavin adenine dinucleotide binding;GO:0050661|NADP binding;","K00485","FMO; dimethylaniline monooxygenase (N-oxide forming) / hypotaurine monooxygenase [EC:1.14.13.8 1.8.1.-]"]
["ENSRNOG00000018054",7,0.581186624,74,4.760452426,0.122086426,-3.034025287,{"v":1.05458e-12,"d":"1.05E-12"},{"v":2.65267e-12,"d":"2.65E-12"},"down","yes","F2rl2","protein_coding","chr2:26972054-26977098:+","gi|39930489|ref|NP_445765.1|",1931,0,"proteinase-activated receptor 3 precursor [Rattus norvegicus]","gi|39930488|ref|NM_053313.1|",1472,0,"Rattus norvegicus coagulation factor II (thrombin) receptor-like 2 (F2rl2), mRNA","Q920E1",748,0,"Proteinase-activated receptor 3",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007596|blood coagulation;GO:0009611|response to wounding;GO:0035025|positive regulation of Rho protein signal transduction;GO:0051482|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway;GO:0070493|thrombin-activated receptor signaling pathway;","GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0032991|protein-containing complex;","GO:0004930|G protein-coupled receptor activity;GO:0015057|thrombin-activated receptor activity;","K04235","F2RL2, PAR3; coagulation factor II (thrombin) receptor-like 2"]
["ENSRNOG00000052725",13,1.079346587,91,5.854069875,0.184375419,-2.439281766,{"v":1.92049E-12,"d":"1.92E-12"},{"v":4.76887e-12,"d":"4.77E-12"},"down","yes","Shisal1","protein_coding","chr7:115509035-115575449:-","gi|568993424|ref|XP_006521503.1|",876,{"v":1e-104,"d":"1.00E-104"},"PREDICTED: uncharacterized protein KIAA1644 isoform X2 [Mus musculus]","gi|672060434|ref|XR_593666.1|",3776,0,"PREDICTED: Rattus norvegicus similar to mKIAA1644 protein (RGD1566029), transcript variant X12, misc_RNA","Q0VBP7",320,{"v":2e-98,"d":"2.00E-98"},"Protein shisa-like-1",".",".",".",".","pfam13908","Shisa","Wnt and FGF inhibitory regulator. Shisa is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000071170",100,8.302666052,278,17.88386182,0.464254653,-1.107011727,{"v":1.99854e-12,"d":"2.00E-12"},{"v":4.95496e-12,"d":"4.95E-12"},"down","yes","ENSRNOG00000071170","protein_coding","chr14:1406798-1433187:-","gi|293341562|ref|XP_002724970.1|",5010,0,"PREDICTED: GPI ethanolamine phosphate transferase 2 isoform X1 [Rattus norvegicus]","gi|672027597|ref|XM_002724924.4|",3398,0,"PREDICTED: Rattus norvegicus phosphatidylinositol glycan anchor biosynthesis, class G (Pigg), transcript variant X1, mRNA","Q5H8A4",1528,0,"GPI ethanolamine phosphate transferase 2","SPAC13G6.03",268,{"v":3e-75,"d":"3.00E-75"},"COG1524","pfam01663","Phosphodiest","Type I phosphodiesterase / nucleotide pyrophosphatase. This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyse the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars. Also in this family is ATX an autotaxin, tumor cell motility-stimulating protein which exhibits type I phosphodiesterases activity. The alignment encompasses the active site. Also present with in this family is 60-kDa Ca2+-ATPase form F. odoratum.",".",".",".",".","."]
["ENSRNOG00000007662",97,8.053586071,272,17.49787919,0.460260697,-1.119476843,{"v":2.19615e-12,"d":"2.20E-12"},{"v":5.43017e-12,"d":"5.43E-12"},"down","yes","Zfp800","protein_coding","chr4:56826997-56849791:-","gi|672049251|ref|XP_008761034.1|",3217,0,"PREDICTED: zinc finger protein 800 isoform X2 [Rattus norvegicus]","gi|672049256|ref|XM_008762815.1|",2802,0,"PREDICTED: Rattus norvegicus zinc finger protein 800 (Zfp800), transcript variant X4, mRNA","Q0VEE6",1209,0,"Zinc finger protein 800",".",".",".",".","pfam13912","zf-C2H2_6","C2H2-type zinc finger.",".",".",".",".","."]
["ENSRNOG00000067812",53,4.400413008,184,11.83680063,0.371756959,-1.427568345,{"v":2.92191E-12,"d":"2.92E-12"},{"v":7.14455e-12,"d":"7.14E-12"},"down","yes","ENSRNOG00000067812","protein_coding","chr16:19762596-19855715:+","gi|564388777|ref|XP_006253050.1|",3586,0,"PREDICTED: zinc finger protein 14 isoform X1 [Rattus norvegicus]","gi|672079968|ref|XM_006252988.2|",2539,0,"PREDICTED: Rattus norvegicus zinc finger protein 709-like (LOC102551257), transcript variant X1, mRNA","Q8N972",680,0,"Zinc finger protein 709","SPAC144.09c",109,{"v":6e-24,"d":"6.00E-24"},"COG5048","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000000563",121,10.04622592,315,20.26408803,0.495765016,-1.012271625,{"v":3.38829e-12,"d":"3.39E-12"},{"v":8.25021e-12,"d":"8.25E-12"},"down","yes","Adamts14","protein_coding","chr20:29144354-29219866:-","gi|564397940|ref|XP_006256511.1|",6184,0,"PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 14 isoform X1 [Rattus norvegicus]","gi|672086218|ref|XM_006256449.2|",3776,0,"PREDICTED: Rattus norvegicus ADAM metallopeptidase with thrombospondin type 1 motif, 14 (Adamts14), transcript variant X1, mRNA","Q8WXS8",1941,0,"A disintegrin and metalloproteinase with thrombospondin motifs 14",".",".",".",".","pfam05986","ADAM_spacer1","ADAM-TS Spacer 1. This family represents the Spacer-1 region from the ADAM-TS family of metalloproteinases.","GO:0006508|proteolysis;GO:0008150|biological_process;GO:0030198|extracellular matrix organization;GO:0030199|collagen fibril organization;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0031012|extracellular matrix;","GO:0003674|molecular_function;GO:0004222|metalloendopeptidase activity;GO:0008233|peptidase activity;GO:0046872|metal ion binding;","K08628","ADAMTS14; a disintegrin and metalloproteinase with thrombospondin motifs 14 [EC:3.4.24.-]"]
["ENSRNOG00000011841",77,6.39305286,232,14.92466166,0.428354961,-1.223121298,{"v":3.4301e-12,"d":"3.43E-12"},{"v":8.34884e-12,"d":"8.35E-12"},"down","yes","Map2","protein_coding","chr9:67723371-67979809:+","gi|672065487|ref|XP_008765425.1|",7966,0,"PREDICTED: microtubule-associated protein 2 isoform X6 [Rattus norvegicus]","gi|672065486|ref|XM_008767203.1|",5426,0,"PREDICTED: Rattus norvegicus microtubule-associated protein 2 (Map2), transcript variant X7, mRNA","P15146",2900,0,"Microtubule-associated protein 2",".",".",".",".","pfam08377","MAP2_projctn","MAP2/Tau projection domain. This domain is found in the MAP2/Tau family of proteins which includes MAP2, MAP4, Tau, and their homologs. All isoforms contain a conserved C-terminal domain containing tubulin-binding repeats (pfam00418), and a N-terminal projection domain of varying size. This domain has a net negative charge and exerts a long-range repulsive force. This provides a mechanism that can regulate microtubule spacing which might facilitate efficient organelle transport.","GO:0000226|microtubule cytoskeleton organization;GO:0001578|microtubule bundle formation;GO:0007026|negative regulation of microtubule depolymerization;GO:0007409|axonogenesis;GO:0016358|dendrite development;GO:0021954|central nervous system neuron development;GO:0030010|establishment of cell polarity;GO:0030517|negative regulation of axon extension;GO:0031115|negative regulation of microtubule polymerization;GO:0031175|neuron projection development;GO:0032355|response to estradiol;GO:0032570|response to progesterone;GO:0048813|dendrite morphogenesis;GO:0071310|cellular response to organic substance;GO:1901953|positive regulation of anterograde dense core granule transport;GO:1902513|regulation of organelle transport along microtubule;GO:1903744|positive regulation of anterograde synaptic vesicle transport;GO:1903827|regulation of cellular protein localization;GO:1904527|negative regulation of microtubule binding;","GO:0005737|cytoplasm;GO:0005790|smooth endoplasmic reticulum;GO:0005791|rough endoplasmic reticulum;GO:0005874|microtubule;GO:0014069|postsynaptic density;GO:0015629|actin cytoskeleton;GO:0015630|microtubule cytoskeleton;GO:0030424|axon;GO:0030425|dendrite;GO:0032587|ruffle membrane;GO:0032839|dendrite cytoplasm;GO:0032991|protein-containing complex;GO:0034399|nuclear periphery;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043194|axon initial segment;GO:0043198|dendritic shaft;GO:0043203|axon hillock;GO:0044294|dendritic growth cone;GO:0044297|cell body;GO:0044307|dendritic branch;GO:0097440|apical dendrite;GO:0097441|basal dendrite;GO:0097442|CA3 pyramidal cell dendrite;GO:0150001|primary dendrite;GO:0150002|distal dendrite;GO:0150014|apical distal dendrite;GO:1902737|dendritic filopodium;GO:1990635|proximal dendrite;GO:1990769|proximal neuron projection;","GO:0002162|dystroglycan binding;GO:0003779|actin binding;GO:0005515|protein binding;GO:0005516|calmodulin binding;GO:0008017|microtubule binding;GO:0015631|tubulin binding;GO:0019901|protein kinase binding;","K10430","MAP2; microtubule-associated protein 2"]
["ENSRNOG00000050630",89,7.389372787,255,16.40426174,0.450454455,-1.15054685,{"v":3.66244e-12,"d":"3.66E-12"},{"v":8.89404e-12,"d":"8.89E-12"},"down","yes","AABR07070043.1","protein_coding","chr8:41698712-41717583:+","gi|8393418|ref|NP_058704.1|",1734,0,"glyceraldehyde-3-phosphate dehydrogenase [Rattus norvegicus]","gi|402691727|ref|NM_017008.4|",1197,0,"Rattus norvegicus glyceraldehyde-3-phosphate dehydrogenase (Gapdh), mRNA","P04797",672,0,"Glyceraldehyde-3-phosphate dehydrogenase","SPBC354.12",494,{"v":1E-172,"d":"1.00E-172"},"COG0057","pfam02800","Gp_dh_C","Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain. GAPDH is a tetrameric NAD-binding enzyme involved in glycolysis and glyconeogenesis. C-terminal domain is a mixed alpha/antiparallel beta fold.",".",".",".",".","."]
["ENSRNOG00000011323",63,5.230679613,203,13.05907895,0.400539704,-1.319982838,{"v":4.91568e-12,"d":"4.92E-12"},{"v":1.18564e-11,"d":"1.19E-11"},"down","yes","Lgi3","protein_coding","chr15:45605611-45612739:+","gi|157822677|ref|NP_001100747.1|",2702,0,"leucine-rich repeat LGI family member 3 precursor [Rattus norvegicus]","gi|157822676|ref|NM_001107277.1|",3319,0,"Rattus norvegicus leucine-rich repeat LGI family, member 3 (Lgi3), mRNA","Q8K406",1030,0,"Leucine-rich repeat LGI family member 3",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.","GO:0017157|regulation of exocytosis;","GO:0005576|extracellular region;GO:0008021|synaptic vesicle;","GO:0003824|catalytic activity;","K19999","LGI3; leucine-rich repeat LGI family member 3"]
["ENSRNOG00000013825",52,4.317386347,180,11.57947887,0.37284807,-1.423340222,{"v":5.59015e-12,"d":"5.59E-12"},{"v":1.34174e-11,"d":"1.34E-11"},"down","yes","Rap1gap","protein_coding","chr5:149892019-149939253:+","gi|406362832|ref|NP_001094183.1|",3802,0,"rap1 GTPase-activating protein 1 [Rattus norvegicus]","gi|406362831|ref|NM_001100713.1|",3297,0,"Rattus norvegicus Rap1 GTPase-activating protein (Rap1gap), mRNA","A2ALS5",1251,0,"Rap1 GTPase-activating protein 1",".",".",".",".","pfam02145","Rap_GAP","Rap/ran-GAP.","GO:0022409|positive regulation of cell-cell adhesion;GO:0043087|regulation of GTPase activity;GO:0043547|positive regulation of GTPase activity;GO:0045665|negative regulation of neuron differentiation;GO:0050766|positive regulation of phagocytosis;GO:0051056|regulation of small GTPase mediated signal transduction;GO:0090630|activation of GTPase activity;GO:1903697|negative regulation of microvillus assembly;GO:1904425|negative regulation of GTP binding;GO:1904442|negative regulation of thyroid gland epithelial cell proliferation;GO:1990792|cellular response to glial cell derived neurotrophic factor;","GO:0005737|cytoplasm;GO:0005769|early endosome;GO:0005829|cytosol;GO:0016020|membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0043025|neuronal cell body;","GO:0005096|GTPase activator activity;GO:0005515|protein binding;GO:0031267|small GTPase binding;GO:0042803|protein homodimerization activity;","K17700","RAP1GAP, RAPGAP; RAP1 GTPase activating protein 1"]
["ENSRNOG00000014652",15,1.245399908,94,6.047061189,0.205951266,-2.2796251,{"v":6.22065e-12,"d":"6.22E-12"},{"v":1.49028e-11,"d":"1.49E-11"},"down","yes","Aqp8","protein_coding","chr1:177993305-177999158:+","gi|564330829|ref|XP_006230249.1|",1239,{"v":3e-166,"d":"3.00E-166"},"PREDICTED: aquaporin-8 isoform X1 [Rattus norvegicus]","gi|672037739|ref|XM_006230187.2|",1512,0,"PREDICTED: Rattus norvegicus aquaporin 8 (Aqp8), transcript variant X1, mRNA","P56405",477,{"v":7e-166,"d":"7.00E-166"},"Aquaporin-8","SMc01870",73.9,{"v":5e-14,"d":"5.00E-14"},"COG0580","pfam00230","MIP","Major intrinsic protein. MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.","GO:0006833|water transport;GO:0015722|canalicular bile acid transport;GO:0055085|transmembrane transport;GO:0071320|cellular response to cAMP;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0045177|apical part of cell;GO:0046691|intracellular canaliculus;GO:0046930|pore complex;","GO:0015250|water channel activity;GO:0015288|porin activity;","K09869","AQP8; aquaporin-8"]
["ENSRNOG00000070692",1,0.083026661,49,3.152191471,0.026339346,-5.246636688,{"v":8.41555E-12,"d":"8.42E-12"},{"v":2.00111e-11,"d":"2.00E-11"},"down","yes","ENSRNOG00000070692","protein_coding","chr15:4782866-4790453:+","gi|564385445|ref|XP_006251744.1|",666,{"v":1E-78,"d":"1.00E-78"},"PREDICTED: uncharacterized protein LOC102547093 isoform X2 [Rattus norvegicus]","gi|672077354|ref|XR_595997.1|",795,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103693798 (LOC103693798), ncRNA",".",".",".",".",".",".",".",".","pfam04822","Takusan","Takusan. This domain is named takusan, which is a Japanese word meaning 'many'. Members of this family regulate synaptic activity.",".",".",".",".","."]
["ENSRNOG00000015675",3,0.249079982,56,3.602504538,0.069140782,-3.854319265,{"v":8.55969e-12,"d":"8.56E-12"},{"v":2.03312E-11,"d":"2.03E-11"},"down","yes","Nell1","protein_coding","chr1:99709793-100573860:+","gi|149055782|gb|EDM07213.1|",4231,0,"NEL-like 1 (chicken), isoform CRA_a [Rattus norvegicus]","gi|13592010|ref|NM_031069.1|",2869,0,"Rattus norvegicus neural EGFL like 1 (Nell1), mRNA","Q62919",1624,0,"Protein kinase C-binding protein NELL1",".",".",".",".","pfam00093","VWC","von Willebrand factor type C domain. The high cutoff was used to prevent overlap with pfam00094.","GO:0010468|regulation of gene expression;GO:0030154|cell differentiation;GO:0030501|positive regulation of bone mineralization;GO:0033689|negative regulation of osteoblast proliferation;GO:0043065|positive regulation of apoptotic process;GO:0045667|regulation of osteoblast differentiation;GO:0045669|positive regulation of osteoblast differentiation;GO:0045778|positive regulation of ossification;GO:1903363|negative regulation of cellular protein catabolic process;","GO:0005615|extracellular space;GO:0005635|nuclear envelope;GO:0005737|cytoplasm;GO:0048471|perinuclear region of cytoplasm;","GO:0005080|protein kinase C binding;GO:0005509|calcium ion binding;GO:0008201|heparin binding;GO:0042802|identical protein binding;","K24342","NELL; protein kinase C-binding protein NELL"]
["ENSRNOG00000018858",74,6.143972879,223,14.34568772,0.428280122,-1.223373378,{"v":8.87468e-12,"d":"8.87E-12"},{"v":2.10559e-11,"d":"2.11E-11"},"down","yes","Myct1","protein_coding","chr1:42018137-42029410:+","gi|880862699|ref|XP_005065952.2|",1103,{"v":5e-146,"d":"5.00E-146"},"PREDICTED: myc target protein 1 [Mesocricetus auratus]","gi|157818952|ref|NM_001106207.1|",1560,0,"Rattus norvegicus myc target 1 (Myct1), mRNA","Q8R411",363,{"v":2e-122,"d":"2.00E-122"},"Myc target protein 1",".",".",".",".","pfam15179","Myc_target_1","Myc target protein 1. This family of proteins is regulated by the c-Myc oncoprotein. It regulates the expression of several other c-Myc target genes.","GO:0061484|hematopoietic stem cell homeostasis;","GO:0005654|nucleoplasm;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;",".",".","."]
["ENSRNOG00000062469",18,1.494479889,100,6.433043818,0.232313028,-2.105858032,{"v":1.47583E-11,"d":"1.48E-11"},{"v":3.44024e-11,"d":"3.44E-11"},"down","yes","Ccdc194","protein_coding","chr16:18205095-18209283:-","gi|407263515|ref|XP_003945491.1|",558,{"v":6e-64,"d":"6.00E-64"},"PREDICTED: nestin [Mus musculus]","gi|755526175|ref|XM_011242347.1|",795,0,"PREDICTED: Mus musculus RIKEN cDNA C430049E01 gene (C430049E01Rik), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam15547","DUF4654","Domain of unknown function (DUF4654). This family of proteins is found in eukaryotes. Proteins in this family are typically between 145 and 169 amino acids in length. There is a conserved IDC sequence motif.",".",".",".",".","."]
["ENSRNOG00000026036",77,6.39305286,227,14.60300947,0.437790092,-1.19168879,{"v":1.54927e-11,"d":"1.55E-11"},{"v":3.60618e-11,"d":"3.61E-11"},"down","yes","Pdyn","protein_coding","chr3:116900992-116913334:-","gi|186700610|ref|NP_062247.2|",1191,{"v":6e-155,"d":"6.00E-155"},"proenkephalin-B preproprotein [Rattus norvegicus]","gi|186700609|ref|NM_019374.3|",2439,0,"Rattus norvegicus prodynorphin (Pdyn), mRNA","P06300",460,{"v":3e-155,"d":"3.00E-155"},"Proenkephalin-B",".",".",".",".","pfam01160","Opiods_neuropep","Vertebrate endogenous opioids neuropeptide.","GO:0007218|neuropeptide signaling pathway;GO:0007268|chemical synaptic transmission;GO:0007600|sensory perception;GO:0046928|regulation of neurotransmitter secretion;","GO:0005576|extracellular region;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0008021|synaptic vesicle;GO:0030425|dendrite;GO:0043025|neuronal cell body;GO:0043679|axon terminus;GO:0045202|synapse;GO:0099013|neuronal dense core vesicle lumen;","GO:0001515|opioid peptide activity;GO:0005515|protein binding;GO:0031628|opioid receptor binding;","K15840","PDYN, PENKB; proenkephalin B (prodynorphin)"]
["ENSRNOG00000002338",72,5.977919558,217,13.95970509,0.42822678,-1.223553075,{"v":1.67325e-11,"d":"1.67E-11"},{"v":3.88346e-11,"d":"3.88E-11"},"down","yes","Dgke","protein_coding","chr10:73855583-73877100:-","gi|564373655|ref|XP_006247132.1|",2984,0,"PREDICTED: diacylglycerol kinase epsilon isoform X1 [Rattus norvegicus]","gi|672068870|ref|XM_006247070.2|",3007,0,"PREDICTED: Rattus norvegicus diacylglycerol kinase, epsilon 64kDa (Dgke), transcript variant X1, mRNA","Q9R1C6",1083,0,"Diacylglycerol kinase epsilon",".",".",".",".","pfam00609","DAGK_acc","Diacylglycerol kinase accessory domain. Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. This domain is assumed to be an accessory domain: its function is unknown.","GO:0006654|phosphatidic acid biosynthetic process;GO:0006661|phosphatidylinositol biosynthetic process;GO:0007205|protein kinase C-activating G protein-coupled receptor signaling pathway;GO:0035556|intracellular signal transduction;GO:0046339|diacylglycerol metabolic process;GO:0046834|lipid phosphorylation;GO:0050804|modulation of chemical synaptic transmission;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0098978|glutamatergic synapse;","GO:0003951|NAD+ kinase activity;GO:0004143|diacylglycerol kinase activity;GO:0005524|ATP binding;GO:0016301|kinase activity;","K00901","dgkA, DGK; diacylglycerol kinase (ATP) [EC:2.7.1.107]"]
["ENSRNOG00000038413",2,0.166053321,51,3.280852347,0.05061286,-4.304352186,{"v":1.6759E-11,"d":"1.68E-11"},{"v":3.8882e-11,"d":"3.89E-11"},"down","yes","Olr1433","protein_coding","chr10:43037857-43046701:+","gi|47576039|ref|NP_001000525.1|",1491,0,"olfactory receptor Olr1433 [Rattus norvegicus]","gi|34849931|gb|AC109605.14|",1186,0,"Mus musculus strain 129S6/SvEvTac clone rp22-470o15 map 11, complete sequence","Q7Z3T1",459,{"v":7e-152,"d":"7.00E-152"},"Olfactory receptor 2W3",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0050911|detection of chemical stimulus involved in sensory perception of smell;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004984|olfactory receptor activity;","K04257","OLFR; olfactory receptor"]
["ENSRNOG00000007949",64,5.313706274,201,12.93041808,0.410946208,-1.282978535,{"v":1.76615E-11,"d":"1.77E-11"},{"v":4.08869e-11,"d":"4.09E-11"},"down","yes","Rgn","protein_coding","chrX:1619032-1634450:-","gi|13928740|ref|NP_113734.1|",1597,0,"regucalcin [Rattus norvegicus]","gi|50927600|gb|BC078794.1|",1591,0,"Rattus norvegicus regucalcin (senescence marker protein-30), mRNA (cDNA clone MGC:93360 IMAGE:7126233), complete cds","Q03336",619,0,"Regucalcin","BS_yvrE",174,{"v":6E-49,"d":"6.00E-49"},"COG3386","pfam08450","SGL","SMP-30/Gluconolaconase/LRE-like region. This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.","GO:0001822|kidney development;GO:0001889|liver development;GO:0001933|negative regulation of protein phosphorylation;GO:0006469|negative regulation of protein kinase activity;GO:0006874|cellular calcium ion homeostasis;GO:0007283|spermatogenesis;GO:0007568|aging;GO:0010867|positive regulation of triglyceride biosynthetic process;GO:0010907|positive regulation of glucose metabolic process;GO:0010922|positive regulation of phosphatase activity;GO:0019853|L-ascorbic acid biosynthetic process;GO:0032515|negative regulation of phosphoprotein phosphatase activity;GO:0032781|positive regulation of ATPase activity;GO:0034260|negative regulation of GTPase activity;GO:0043066|negative regulation of apoptotic process;GO:0043547|positive regulation of GTPase activity;GO:0045019|negative regulation of nitric oxide biosynthetic process;GO:0045723|positive regulation of fatty acid biosynthetic process;GO:0050680|negative regulation of epithelial cell proliferation;GO:0050848|regulation of calcium-mediated signaling;GO:0051344|negative regulation of cyclic-nucleotide phosphodiesterase activity;GO:0097421|liver regeneration;GO:1901318|negative regulation of flagellated sperm motility;GO:1901671|positive regulation of superoxide dismutase activity;GO:1901896|positive regulation of calcium-transporting ATPase activity;GO:1902679|negative regulation of RNA biosynthetic process;GO:1903011|negative regulation of bone development;GO:1903052|positive regulation of proteolysis involved in cellular protein catabolic process;GO:1903611|negative regulation of calcium-dependent ATPase activity;GO:1903625|negative regulation of DNA catabolic process;GO:1903629|positive regulation of dUTP diphosphatase activity;GO:1903634|negative regulation of leucine-tRNA ligase activity;GO:2000279|negative regulation of DNA biosynthetic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004341|gluconolactonase activity;GO:0005509|calcium ion binding;GO:0008270|zinc ion binding;GO:0030234|enzyme regulator activity;","K01053","gnl, RGN; gluconolactonase [EC:3.1.1.17]"]
["ENSRNOG00000048472",19,1.57750655,102,6.561704695,0.240411086,-2.056424672,{"v":1.88497E-11,"d":"1.88E-11"},{"v":4.35588e-11,"d":"4.36E-11"},"down","yes","Comp","protein_coding","chr16:19047207-19055845:-","gi|6978679|ref|NP_036966.1|",2749,0,"cartilage oligomeric matrix protein precursor [Rattus norvegicus]","gi|672079513|ref|XM_006252822.2|",2022,0,"PREDICTED: Rattus norvegicus cartilage oligomeric matrix protein (Comp), transcript variant X1, mRNA","P35444",1063,0,"Cartilage oligomeric matrix protein",".",".",".",".","pfam05735","TSP_C","Thrombospondin C-terminal region. This region is found at the C-terminus of thrombospondin and related proteins.","GO:0001501|skeletal system development;GO:0001503|ossification;GO:0002063|chondrocyte development;GO:0003416|endochondral bone growth;GO:0003417|growth plate cartilage development;GO:0006915|apoptotic process;GO:0006986|response to unfolded protein;GO:0007155|cell adhesion;GO:0007596|blood coagulation;GO:0009306|protein secretion;GO:0010259|multicellular organism aging;GO:0010260|animal organ senescence;GO:0010468|regulation of gene expression;GO:0014829|vascular smooth muscle contraction;GO:0016485|protein processing;GO:0030199|collagen fibril organization;GO:0030282|bone mineralization;GO:0030500|regulation of bone mineralization;GO:0030509|BMP signaling pathway;GO:0035264|multicellular organism growth;GO:0035988|chondrocyte proliferation;GO:0035989|tendon development;GO:0043066|negative regulation of apoptotic process;GO:0043588|skin development;GO:0048844|artery morphogenesis;GO:0050881|musculoskeletal movement;GO:0050905|neuromuscular process;GO:0051216|cartilage development;GO:0055001|muscle cell development;GO:0060173|limb development;GO:0060349|bone morphogenesis;GO:0070527|platelet aggregation;GO:0097084|vascular smooth muscle cell development;GO:0098868|bone growth;GO:1900047|negative regulation of hemostasis;GO:1902732|positive regulation of chondrocyte proliferation;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0032991|protein-containing complex;GO:0062023|collagen-containing extracellular matrix;","GO:0001968|fibronectin binding;GO:0002020|protease binding;GO:0005178|integrin binding;GO:0005201|extracellular matrix structural constituent;GO:0005499|vitamin D binding;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0005518|collagen binding;GO:0008201|heparin binding;GO:0036122|BMP binding;GO:0043394|proteoglycan binding;GO:0043395|heparan sulfate proteoglycan binding;","K04659","THBS2S; thrombospondin 2/3/4/5"]
["ENSRNOG00000053875",65,5.396732934,202,12.99474851,0.415301068,-1.267770514,{"v":2.41345e-11,"d":"2.41E-11"},{"v":5.53509e-11,"d":"5.54E-11"},"down","yes","Nacad","protein_coding","chr14:81465299-81473781:-","gi|695917192|ref|NP_001094125.2|",3344,0,"NAC-alpha domain-containing protein 1 [Rattus norvegicus]","gi|695917191|ref|NM_001100655.2|",2299,0,"Rattus norvegicus NAC alpha domain containing (Nacad), mRNA","Q5SWP3",1031,0,"NAC-alpha domain-containing protein 1","SPBC25H2.05",113,{"v":9e-27,"d":"9.00E-27"},"COG1308","pfam01849","NAC","NAC domain.","GO:0006612|protein targeting to membrane;","GO:0005737|cytoplasm;GO:0005854|nascent polypeptide-associated complex;","GO:0051082|unfolded protein binding;",".","."]
["ENSRNOG00000000177",72,5.977919558,215,13.83104421,0.432210285,-1.210194692,{"v":3.07101e-11,"d":"3.07E-11"},{"v":7.00048e-11,"d":"7.00E-11"},"down","yes","Plpp2","protein_coding","chr7:10175948-10184071:+","gi|21245102|ref|NP_640345.1|",1296,{"v":5e-174,"d":"5.00E-174"},"phospholipid phosphatase 2 [Rattus norvegicus]","gi|21245101|ref|NM_139252.1|",1595,0,"Rattus norvegicus phospholipid phosphatase 2 (Plpp2), mRNA","Q8K593",503,{"v":2E-175,"d":"2.00E-175"},"Phospholipid phosphatase 2","ECU10g1440",80.5,{"v":4e-16,"d":"4.00E-16"},"COG0671","pfam01569","PAP2","PAP2 superfamily. This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidizing halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.","GO:0006644|phospholipid metabolic process;GO:0006670|sphingosine metabolic process;GO:0006672|ceramide metabolic process;GO:0007165|signal transduction;GO:0046839|phospholipid dephosphorylation;GO:1902806|regulation of cell cycle G1/S phase transition;","GO:0005769|early endosome;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005901|caveola;GO:0016021|integral component of membrane;GO:0031901|early endosome membrane;","GO:0008195|phosphatidate phosphatase activity;GO:0042392|sphingosine-1-phosphate phosphatase activity;GO:0042577|lipid phosphatase activity;","K01080","PLPP1_2_3; phosphatidate phosphatase [EC:3.1.3.4]"]
["ENSRNOG00000065794",40,3.321066421,149,9.58523529,0.346477298,-1.529167269,{"v":3.78873e-11,"d":"3.79E-11"},{"v":8.56328e-11,"d":"8.56E-11"},"down","yes","Mafk","lncRNA","chr12:14832249-14858888:-","gi|149035030|gb|EDL89750.1|",720,{"v":1E-83,"d":"1.00E-83"},"v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) [Rattus norvegicus]","gi|47575873|ref|NM_145673.2|",2646,0,"Rattus norvegicus v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K (Mafk), mRNA","Q61827",268,{"v":1e-80,"d":"1.00E-80"},"Transcription factor MafK",".",".",".",".","pfam03131","bZIP_Maf","bZIP Maf transcription factor. Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerization and DNA binding property. Thus, this family is probably related to pfam00170. This family also includes the DNA_binding domain of Skn-1, this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer.",".",".",".",".","."]
["ENSRNOG00000038877",108,8.966879337,282,18.14118357,0.494283039,-1.016590694,{"v":3.86772e-11,"d":"3.87E-11"},{"v":8.73256e-11,"d":"8.73E-11"},"down","yes","Btn2a2","protein_coding","chr17:41620839-41632618:+","gi|392333918|ref|XP_001072372.3|",2612,0,"PREDICTED: butyrophilin subfamily 2 member A2 [Rattus norvegicus]","gi|672030060|ref|XM_001072372.5|",2149,0,"PREDICTED: Rattus norvegicus butyrophilin, subfamily 2, member A2 (Btn2a2), mRNA","A4QPC6",905,0,"Butyrophilin subfamily 2 member A2",".",".",".",".","pfam13765","PRY","SPRY-associated domain. SPRY and PRY domains occur on PYRIN proteins. Their function is not known.","GO:0001817|regulation of cytokine production;GO:0001818|negative regulation of cytokine production;GO:0014067|negative regulation of phosphatidylinositol 3-kinase signaling;GO:0031324|negative regulation of cellular metabolic process;GO:0045591|positive regulation of regulatory T cell differentiation;GO:0046007|negative regulation of activated T cell proliferation;GO:0050852|T cell receptor signaling pathway;GO:0050860|negative regulation of T cell receptor signaling pathway;GO:0051898|negative regulation of protein kinase B signaling;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:2000134|negative regulation of G1/S transition of mitotic cell cycle;","GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0005102|signaling receptor binding;","K06712","BTN, CD277; butyrophilin"]
["ENSRNOG00000050647",89,7.389372787,245,15.76095736,0.468840352,-1.092831352,{"v":6.34728e-11,"d":"6.35E-11"},{"v":1.41412E-10,"d":"1.41E-10"},"down","yes","ENSRNOG00000050647","protein_coding","chr20:3856006-3873240:+","gi|47059179|ref|NP_997669.1|",2882,0,"heat shock 70kD protein 1B [Rattus norvegicus]","gi|260064044|ref|NM_031971.2|",1919,0,"Rattus norvegicus heat shock 70kD protein 1A (Hspa1a), mRNA","P0DMW1",1114,0,"Heat shock 70 kDa protein 1B",".",".",".",".","pfam00012","HSP70","Hsp70 protein. Hsp70 chaperones help to fold many proteins. Hsp70 assisted folding involves repeated cycles of substrate binding and release. Hsp70 activity is ATP dependent. Hsp70 proteins are made up of two regions: the amino terminus is the ATPase domain and the carboxyl terminus is the substrate binding region.","GO:0000723|telomere maintenance;GO:0001916|positive regulation of T cell mediated cytotoxicity;GO:0002931|response to ischemia;GO:0006281|DNA repair;GO:0006402|mRNA catabolic process;GO:0006457|protein folding;GO:0006952|defense response;GO:0006986|response to unfolded protein;GO:0007041|lysosomal transport;GO:0007339|binding of sperm to zona pellucida;GO:0008285|negative regulation of cell proliferation;GO:0009314|response to radiation;GO:0009408|response to heat;GO:0009612|response to mechanical stimulus;GO:0010628|positive regulation of gene expression;GO:0016192|vesicle-mediated transport;GO:0030182|neuron differentiation;GO:0030308|negative regulation of cell growth;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0031396|regulation of protein ubiquitination;GO:0031397|negative regulation of protein ubiquitination;GO:0032436|positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032757|positive regulation of interleukin-8 production;GO:0033120|positive regulation of RNA splicing;GO:0034605|cellular response to heat;GO:0034620|cellular response to unfolded protein;GO:0042026|protein refolding;GO:0043066|negative regulation of apoptotic process;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045471|response to ethanol;GO:0045648|positive regulation of erythrocyte differentiation;GO:0045666|positive regulation of neuron differentiation;GO:0045906|negative regulation of vasoconstriction;GO:0046034|ATP metabolic process;GO:0050821|protein stabilization;GO:0051085|chaperone cofactor-dependent protein refolding;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051131|chaperone-mediated protein complex assembly;GO:0060548|negative regulation of cell death;GO:0070370|cellular heat acclimation;GO:0070434|positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0090063|positive regulation of microtubule nucleation;GO:0090084|negative regulation of inclusion body assembly;GO:0097201|negative regulation of transcription from RNA polymerase II promoter in response to stress;GO:1901029|negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;GO:1901673|regulation of mitotic spindle assembly;GO:1902236|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:1902380|positive regulation of endoribonuclease activity;GO:1903265|positive regulation of tumor necrosis factor-mediated signaling pathway;GO:2001240|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;","GO:0002199|zona pellucida receptor complex;GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005813|centrosome;GO:0005814|centriole;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016234|inclusion body;GO:0016235|aggresome;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0016607|nuclear speck;GO:0032991|protein-containing complex;GO:0044297|cell body;GO:0045121|membrane raft;GO:0048471|perinuclear region of cytoplasm;GO:1990904|ribonucleoprotein complex;","GO:0001664|G protein-coupled receptor binding;GO:0002020|protease binding;GO:0003674|molecular_function;GO:0003714|transcription corepressor activity;GO:0005102|signaling receptor binding;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0016887|ATPase activity;GO:0019899|enzyme binding;GO:0031072|heat shock protein binding;GO:0031249|denatured protein binding;GO:0031625|ubiquitin protein ligase binding;GO:0042826|histone deacetylase binding;GO:0044183|protein binding involved in protein folding;GO:0047485|protein N-terminus binding;GO:0051059|NF-kappaB binding;GO:0051082|unfolded protein binding;GO:0051787|misfolded protein binding;GO:0055131|C3HC4-type RING finger domain binding;GO:0097718|disordered domain specific binding;","K03283","HSPA1s; heat shock 70kDa protein 1/2/6/8"]
["ENSRNOG00000071002",78,6.476079521,224,14.41001815,0.449415084,-1.153879547,{"v":6.6383e-11,"d":"6.64E-11"},{"v":1.47587E-10,"d":"1.48E-10"},"down","yes","Kcne4","protein_coding","chr9:80247379-80250979:+","gi|589917750|ref|XP_006972183.1|",669,{"v":2e-83,"d":"2.00E-83"},"PREDICTED: potassium voltage-gated channel subfamily E member 4 [Peromyscus maniculatus bairdii]","gi|672065764|ref|XM_008767283.1|",2985,0,"PREDICTED: Rattus norvegicus potassium voltage-gated channel, Isk-related family, member 4 (Kcne4), transcript variant X1, mRNA","Q9WTW3",251,{"v":1e-75,"d":"1.00E-75"},"Potassium voltage-gated channel subfamily E member 4",".",".",".",".","pfam02060","ISK_Channel","Slow voltage-gated potassium channel.",".",".",".",".","."]
["ENSRNOG00000012324",40,3.321066421,147,9.456574413,0.351191275,-1.509671094,{"v":7.72836e-11,"d":"7.73E-11"},{"v":1.71088e-10,"d":"1.71E-10"},"down","yes","Soga3","protein_coding","chr1:28620293-28701796:-","gi|149032835|gb|EDL87690.1|",3541,0,"similar to intracellular protein transport like (XM453) (predicted) [Rattus norvegicus]","gi|120953218|ref|NM_026138.2|",2587,0,"Mus musculus SOGA family member 3 (Soga3), mRNA","Q6NZL0",1323,0,"Protein SOGA3",".",".",".",".","pfam14818","DUF4482","Domain of unknown function (DUF4482). This family is found in eukaryotes, and is approximately 140 amino acids in length. The family is found in association with pfam11365.","GO:0010506|regulation of autophagy;","GO:0005615|extracellular space;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000010994",15,1.245399908,88,5.66107856,0.219993398,-2.184467867,{"v":9.18389e-11,"d":"9.18E-11"},{"v":2.02353E-10,"d":"2.02E-10"},"down","yes","Has1","protein_coding","chr1:58693411-58705397:-","gi|27229296|ref|NP_758826.1|",2554,0,"hyaluronan synthase 1 [Rattus norvegicus]","gi|27229295|ref|NM_172323.1|",2092,0,"Rattus norvegicus hyaluronan synthase 1 (Has1), mRNA","Q61647",949,0,"Hyaluronan synthase 1","SMa0866",130,{"v":2e-31,"d":"2.00E-31"},"COG1215","pfam13641","Glyco_tranf_2_3","Glycosyltransferase like family 2. Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.","GO:0010764|negative regulation of fibroblast migration;GO:0030213|hyaluronan biosynthetic process;GO:0036120|cellular response to platelet-derived growth factor stimulus;GO:0044849|estrous cycle;GO:0045226|extracellular polysaccharide biosynthetic process;GO:0085029|extracellular matrix assembly;","GO:0005737|cytoplasm;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;","GO:0042802|identical protein binding;GO:0050501|hyaluronan synthase activity;","K00752","hasA; hyaluronan synthase [EC:2.4.1.212]"]
["ENSRNOG00000004555",45,3.736199724,157,10.0998788,0.369925204,-1.434694496,{"v":9.60221e-11,"d":"9.60E-11"},{"v":2.11279e-10,"d":"2.11E-10"},"down","yes","Sec14l4","protein_coding","chr14:78912750-78956099:+","gi|29427387|sp|Q9Z1J8.1|S14L3_RAT",1935,0,"RecName: Full=SEC14-like protein 3; AltName: Full=45 kDa secretory protein; Short=rsec45","gi|4164417|emb|AJ132352.1|",1119,0,"Rattus norvegicus mRNA for 45 kDa secretory protein, partial","Q9Z1J8",749,0,"SEC14-like protein 3",".",".",".",".","pfam00650","CRAL_TRIO","CRAL/TRIO domain.",".",".","GO:0008289|lipid binding;",".","."]
["ENSRNOG00000065526",70,5.811866237,207,13.3164007,0.436444229,-1.196130784,{"v":1.05866E-10,"d":"1.06E-10"},{"v":2.32298E-10,"d":"2.32E-10"},"down","yes","ENSRNOG00000065526","protein_coding","chr7:7330105-7345177:-","gi|15284007|dbj|BAB63448.1|",1817,0,"gonadotropin inducible ovarian transcription factor 2 beta [Rattus norvegicus]","gi|15284006|dbj|AB047638.1|",1034,0,"Rattus norvegicus GIOT2 beta mRNA for gonadotropin inducible ovarian transcription factor 2 beta, complete cds","E9QAG8",347,{"v":1E-107,"d":"1.00E-107"},"Zinc finger protein 431",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000070245",3,0.249079982,51,3.280852347,0.07591929,-3.719389685,{"v":1.21458E-10,"d":"1.21E-10"},{"v":2.6569e-10,"d":"2.66E-10"},"down","yes","Vstm1","protein_coding","chr1:65687375-65701188:+","gi|564296753|ref|XP_002725553.3|",895,{"v":1e-114,"d":"1.00E-114"},"PREDICTED: V-set and transmembrane domain-containing protein 1 [Rattus norvegicus]","gi|34368610|gb|AC103574.7|",915,0,"Rattus norvegicus 1 BAC CH230-205C19 (Children's Hospital Oakland Research Institute) complete sequence","Q6UX27",167,{"v":2E-46,"d":"2.00E-46"},"V-set and transmembrane domain-containing protein 1",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.",".",".",".",".","."]
["ENSRNOG00000027380",13,1.079346587,82,5.275095931,0.204611746,-2.28903913,{"v":1.22072e-10,"d":"1.22E-10"},{"v":2.66852e-10,"d":"2.67E-10"},"down","yes","Upk1b","protein_coding","chr11:61953648-61991029:+","gi|564376894|ref|XP_006248429.1|",1479,0,"PREDICTED: uroplakin-1b isoform X2 [Rattus norvegicus]","gi|672071154|ref|XM_006248367.2|",1980,0,"PREDICTED: Rattus norvegicus uroplakin 1B (Upk1b), transcript variant X1, mRNA","Q566D0",545,0,"Uroplakin-1b",".",".",".",".","pfam00335","Tetraspannin","Tetraspanin family.","GO:0009617|response to bacterium;GO:0030855|epithelial cell differentiation;","GO:0005887|integral component of plasma membrane;GO:0016324|apical plasma membrane;GO:0120001|apical plasma membrane urothelial plaque;",".","K17347","UPK1; uroplakin-1"]
["ENSRNOG00000048193",93,7.721479429,249,16.01827911,0.482041758,-1.052769965,{"v":1.64644E-10,"d":"1.65E-10"},{"v":3.57227e-10,"d":"3.57E-10"},"down","yes","Hnrnph3","protein_coding","chr20:25614733-25625750:+","gi|767962730|ref|XP_011538044.1|",605,{"v":2e-67,"d":"2.00E-67"},"PREDICTED: heterogeneous nuclear ribonucleoprotein H3 isoform X3 [Homo sapiens]","gi|672086235|ref|XM_006256376.2|",1791,0,"PREDICTED: Rattus norvegicus heterogeneous nuclear ribonucleoprotein H3 (2H9) (Hnrnph3), transcript variant X1, mRNA","P31942",177,{"v":2E-46,"d":"2.00E-46"},"Heterogeneous nuclear ribonucleoprotein H3","YJL177w",56.2,7e-08,"COG0091","pfam14259","RRM_6","RNA recognition motif (a.k.a. RRM, RBD, or RNP domain).","GO:0008150|biological_process;GO:0030855|epithelial cell differentiation;GO:0043484|regulation of RNA splicing;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:1990904|ribonucleoprotein complex;","GO:0003674|molecular_function;GO:0003723|RNA binding;","K12898","HNRNPF_H; heterogeneous nuclear ribonucleoprotein F/H"]
["ENSRNOG00000027837",36,2.988959779,136,8.748939593,0.341636806,-1.549464684,{"v":1.78881e-10,"d":"1.79E-10"},{"v":3.86545e-10,"d":"3.87E-10"},"down","yes","ENSRNOG00000027837","protein_coding","chrX:115675427-115725925:-","gi|149059998|gb|EDM10814.1|",2618,0,"similar to novel protein (predicted), partial [Rattus norvegicus]","gi|755490487|ref|XM_006544556.2|",1435,0,"PREDICTED: Mus musculus predicted gene 14569 (Gm14569), transcript variant X3, mRNA","E9Q0C6",484,{"v":3e-140,"d":"3.00E-140"},"Acrosomal protein KIAA1210",".",".",".",".","pfam15262","DUF4592","Domain of unknown function (DUF4592). This protein family is a domain of unknown function, which lies to the N-terminus of the protein. This domain family is found in eukaryotes, and is typically between 114 and 130 amino acids in length. There are two completely conserved residues (L and A) that may be functionally important. In humans, the gene that encodes this protein lies in the position, chromosome 2 open reading frame 55.",".","GO:0001669|acrosomal vesicle;GO:0061832|basal ectoplasmic specialization;",".",".","."]
["ENSRNOG00000054311",13,1.079346587,81,5.210765493,0.207137817,-2.271337129,{"v":1.92268e-10,"d":"1.92E-10"},{"v":4.1449e-10,"d":"4.14E-10"},"down","yes","ENSRNOG00000054311","lncRNA","chr12:36918224-36920511:-",".",".",".",".","gi|672026799|ref|XR_339554.2|",961,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102551526 (LOC102551526), ncRNA",".",".",".",".",".",".",".",".","pfam01027","Bax1-I","Inhibitor of apoptosis-promoting Bax1. Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner.",".",".",".",".","."]
["ENSRNOG00000006783",75,6.226999539,214,13.76671377,0.452322874,-1.14457514,{"v":2.29802e-10,"d":"2.30E-10"},{"v":4.9176e-10,"d":"4.92E-10"},"down","yes","Neb","protein_coding","chr3:36613716-36811574:-","gi|537146910|gb|ERE70307.1|",36392,0,"nebulin-like protein [Cricetulus griseus]","gi|568913112|ref|XM_006497765.1|",17931,0,"PREDICTED: Mus musculus nebulin (Neb), transcript variant X17, mRNA","P20929",8955,0,"Nebulin",".",".",".",".","pfam14604","SH3_9","Variant SH3 domain.","GO:0071691|cardiac muscle thin filament assembly;","GO:0030016|myofibril;GO:0030018|Z disc;GO:0043292|contractile fiber;","GO:0051015|actin filament binding;","K18267","NEB; nebulin"]
["ENSRNOG00000046983",35,2.905933118,133,8.555948279,0.33963893,-1.557926262,{"v":2.40647e-10,"d":"2.41E-10"},{"v":5.13249e-10,"d":"5.13E-10"},"down","yes","Adat2","protein_coding","chr1:7954631-7975251:+","gi|169234864|ref|NP_001108500.1|",1023,{"v":4e-138,"d":"4.00E-138"},"tRNA-specific adenosine deaminase 2 [Rattus norvegicus]","gi|169234863|ref|NM_001115028.1|",655,0,"Rattus norvegicus adenosine deaminase, tRNA-specific 2 (Adat2), mRNA","Q6P6J0",391,{"v":1E-136,"d":"1.00E-136"},"tRNA-specific adenosine deaminase 2","YJL035c",124,{"v":1e-32,"d":"1.00E-32"},"COG0590","pfam00383","dCMP_cyt_deam_1","Cytidine and deoxycytidylate deaminase zinc-binding region.",".","GO:0016021|integral component of membrane;",".","K15441","TAD2, ADAT2; tRNA-specific adenosine deaminase 2 [EC:3.5.4.-]"]
["ENSRNOG00000069756",74,6.143972879,211,13.57372246,0.452637285,-1.143572667,{"v":3.15513E-10,"d":"3.16E-10"},{"v":6.68242e-10,"d":"6.68E-10"},"down","yes","Ccdc92b","protein_coding","chr10:59479743-59501495:+","gi|62000658|ref|NP_001013806.1|",742,{"v":1e-85,"d":"1.00E-85"},"uncharacterized protein LOC432582 [Mus musculus]","gi|672068321|ref|XM_008767929.1|",2934,0,"PREDICTED: Rattus norvegicus similar to novel protein (RGD1562276), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam14916","CCDC92","Coiled-coil domain of unknown function. This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The function is not known and the proteins carry no other domains.",".",".",".",".","."]
["ENSRNOG00000014231",5,0.415133303,56,3.602504538,0.115234637,-3.117353671,{"v":3.48513e-10,"d":"3.49E-10"},{"v":7.35212E-10,"d":"7.35E-10"},"down","yes","Pnoc","protein_coding","chr15:39624641-39651867:-","gi|6981378|ref|NP_037139.1|",765,{"v":3E-98,"d":"3.00E-98"},"prepronociceptin precursor [Rattus norvegicus]","gi|672078247|ref|XM_006252199.2|",1015,0,"PREDICTED: Rattus norvegicus prepronociceptin (Pnoc), transcript variant X2, mRNA","Q62923",299,{"v":9e-100,"d":"9.00E-100"},"Prepronociceptin",".",".",".",".","pfam01160","Opiods_neuropep","Vertebrate endogenous opioids neuropeptide.","GO:0007218|neuropeptide signaling pathway;GO:0007268|chemical synaptic transmission;GO:0007565|female pregnancy;GO:0007600|sensory perception;","GO:0005576|extracellular region;GO:0005886|plasma membrane;GO:0030425|dendrite;GO:0043025|neuronal cell body;GO:0043679|axon terminus;","GO:0001515|opioid peptide activity;GO:0031628|opioid receptor binding;","K25696","PNOC; prepronociceptin"]
["ENSRNOG00000018505",98,8.136612731,255,16.40426174,0.49600603,-1.011570437,{"v":3.87177e-10,"d":"3.87E-10"},{"v":8.14359e-10,"d":"8.14E-10"},"down","yes","Cidea","protein_coding","chr18:60894874-60920481:+","gi|281427180|ref|NP_001163938.1|",997,{"v":1e-130,"d":"1.00E-130"},"cell death activator CIDE-A [Rattus norvegicus]","gi|281427179|ref|NM_001170467.1|",870,0,"Rattus norvegicus cell death-inducing DFFA-like effector a (Cidea), mRNA","O70302",359,{"v":1e-120,"d":"1.00E-120"},"Cell death activator CIDE-A",".",".",".",".","pfam02017","CIDE-N","CIDE-N domain. This domain is found in CAD nuclease, and in ICAD, the inhibitor of CAD nuclease. The two proteins interact through this domain.","GO:0001659|temperature homeostasis;GO:0001818|negative regulation of cytokine production;GO:0006629|lipid metabolic process;GO:0006915|apoptotic process;GO:0008150|biological_process;GO:0008219|cell death;GO:0010890|positive regulation of sequestering of triglyceride;GO:0019915|lipid storage;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0032720|negative regulation of tumor necrosis factor production;GO:0035634|response to stilbenoid;GO:0042981|regulation of apoptotic process;GO:0050995|negative regulation of lipid catabolic process;GO:0070417|cellular response to cold;GO:0120163|negative regulation of cold-induced thermogenesis;GO:1900118|negative regulation of execution phase of apoptosis;GO:1902510|regulation of apoptotic DNA fragmentation;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005740|mitochondrial envelope;GO:0005811|lipid droplet;","GO:0003674|molecular_function;GO:0042803|protein homodimerization activity;",".","."]
["ENSRNOG00000004585",51,4.234359687,165,10.6145223,0.398921361,-1.325823716,{"v":4.12605e-10,"d":"4.13E-10"},{"v":8.65564e-10,"d":"8.66E-10"},"down","yes","Tmtc2","protein_coding","chr7:40394220-40807298:-","gi|330340424|ref|NP_001164648.2|",3839,0,"transmembrane and TPR repeat-containing protein 2 precursor [Rattus norvegicus]","gi|755534631|ref|XR_380404.2|",2503,0,"PREDICTED: Mus musculus transmembrane and tetratricopeptide repeat containing 2 (Tmtc2), transcript variant X1, misc_RNA","Q56A06",1452,0,"Transmembrane and TPR repeat-containing protein 2",".",".",".",".","pfam08409","DUF1736","Domain of unknown function (DUF1736). This domain of unknown function is found in various hypothetical metazoan proteins.","GO:0008150|biological_process;GO:0035269|protein O-linked mannosylation;GO:0055074|calcium ion homeostasis;","GO:0005575|cellular_component;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0000030|mannosyltransferase activity;GO:0003674|molecular_function;GO:0004169|dolichyl-phosphate-mannose-protein mannosyltransferase activity;","K23424","TMTC; protein O-mannosyl-transferase [EC:2.4.1.-]"]
["ENSRNOG00000011241",83,6.891212824,227,14.60300947,0.471903606,-1.0834359,{"v":4.19091e-10,"d":"4.19E-10"},{"v":8.78882e-10,"d":"8.79E-10"},"down","yes","Tfdp2","protein_coding","chr8:96760504-96896682:+","gi|564364970|ref|XP_006243625.1|",1702,0,"PREDICTED: transcription factor Dp-2 isoform X7 [Rattus norvegicus]","gi|672062850|ref|XM_006243566.2|",2568,0,"PREDICTED: Rattus norvegicus transcription factor Dp-2 (E2F dimerization partner 2) (Tfdp2), transcript variant X12, mRNA","Q14188",602,0,"Transcription factor Dp-2",".",".",".",".","pfam08781","DP","Transcription factor DP. DP forms a heterodimer with E2F and regulates genes involved in cell cycle progression. The transcriptional activity of E2F is inhibited by the retinoblastoma protein which binds to the E2F-DP heterodimer and negatively regulates the G1-S transition.","GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007507|heart development;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051726|regulation of cell cycle;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0072686|mitotic spindle;GO:0090575|RNA polymerase II transcription factor complex;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003700|DNA-binding transcription factor activity;GO:0019904|protein domain specific binding;","K09392","TFDP2; transcription factor Dp-2"]
["ENSRNOG00000002167",20,1.66053321,97,6.240052504,0.266108852,-1.909911591,{"v":4.43547e-10,"d":"4.44E-10"},{"v":9.27734e-10,"d":"9.28E-10"},"down","yes","Dmp1","protein_coding","chr14:5528431-5539323:-","gi|672075644|ref|XP_008768216.1|",1015,{"v":9e-123,"d":"9.00E-123"},"PREDICTED: dentin matrix acidic phosphoprotein 1 isoform X1 [Rattus norvegicus]","gi|672075645|ref|XM_006250622.2|",2774,0,"PREDICTED: Rattus norvegicus dentin matrix acidic phosphoprotein 1 (Dmp1), transcript variant X2, mRNA","P98193",359,{"v":1e-111,"d":"1.00E-111"},"Dentin matrix acidic phosphoprotein 1",".",".",".",".","pfam07263","DMP1","Dentin matrix protein 1 (DMP1). This family consists of several mammalian dentin matrix protein 1 (DMP1) sequences. The dentin matrix acidic phosphoprotein 1 (DMP1) gene has been mapped to human chromosome 4q21. DMP1 is a bone and teeth specific protein initially identified from mineralised dentin. DMP1 is primarily localized in the nuclear compartment of undifferentiated osteoblasts. In the nucleus, DMP1 acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the early phase of osteoblast maturation, Ca(2+) surges into the nucleus from the cytoplasm, triggering the phosphorylation of DMP1 by a nuclear isoform of casein kinase II. This phosphorylated DMP1 is then exported out into the extracellular matrix, where it regulates nucleation of hydroxyapatite. DMP1 is a unique molecule that initiates osteoblast differentiation by transcription in the nucleus and orchestrates mineralised matrix formation extracellularly, at later stages of osteoblast maturation. The DMP1 gene has been found to be ectopically expressed in lung cancer although the reason for this is unknown.","GO:0001503|ossification;GO:0010811|positive regulation of cell-substrate adhesion;GO:0030198|extracellular matrix organization;GO:0030500|regulation of bone mineralization;GO:0031214|biomineral tissue development;GO:0070173|regulation of enamel mineralization;","GO:0005576|extracellular region;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0031012|extracellular matrix;","GO:0030544|Hsp70 protein binding;GO:0050840|extracellular matrix binding;","K23328","DMP1; dentin matrix acidic phosphoprotein 1"]
["ENSRNOG00000069705",64,5.313706274,190,12.22278326,0.43473783,-1.201782452,{"v":5.27831e-10,"d":"5.28E-10"},{"v":1.09828e-09,"d":"1.10E-09"},"down","yes","ENSRNOG00000069705","lncRNA","chr16:46842387-46854011:-","gi|73532753|ref|NP_001020228.2|",177,{"v":2e-11,"d":"2.00E-11"},"uncharacterized protein LOC502176 [Rattus norvegicus]","gi|959093084|ref|NG_046269.1|",482,0,"Rattus norvegicus Y-linked testis-specific protein 1-like (LOC103694772) pseudogene on chromosome Y",".",".",".",".",".",".",".",".","pfam10110","GPDPase_memb","Membrane domain of glycerophosphoryl diester phosphodiesterase. Members of this family comprise the membrane domain of the prokaryotic enzyme glycerophosphoryl diester phosphodiesterase.",".",".",".",".","."]
["ENSRNOG00000020484",17,1.411453229,89,5.725408998,0.246524437,-2.020197434,{"v":5.62844e-10,"d":"5.63E-10"},{"v":1.16885e-09,"d":"1.17E-09"},"down","yes","Trpm5","protein_coding","chr1:198255723-198277654:-","gi|672039451|ref|XP_008758382.1|",6111,0,"PREDICTED: transient receptor potential cation channel subfamily M member 5 isoform X1 [Rattus norvegicus]","gi|300798669|ref|NM_001191896.1|",3471,0,"Rattus norvegicus transient receptor potential cation channel, subfamily M, member 5 (Trpm5), mRNA","Q9JJH7",2234,0,"Transient receptor potential cation channel subfamily M member 5",".",".",".",".","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0019722|calcium-mediated signaling;GO:0034220|ion transmembrane transport;GO:0035725|sodium ion transmembrane transport;GO:0050909|sensory perception of taste;GO:0070588|calcium ion transmembrane transport;GO:0071805|potassium ion transmembrane transport;GO:0098655|cation transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0030425|dendrite;GO:0043025|neuronal cell body;","GO:0005227|calcium activated cation channel activity;GO:0005261|cation channel activity;GO:0005267|potassium channel activity;GO:0005272|sodium channel activity;GO:0099604|ligand-gated calcium channel activity;","K04980","TRPM5; transient receptor potential cation channel subfamily M member 5"]
["ENSRNOG00000010853",10,0.830266605,70,4.503130673,0.184375419,-2.439281766,{"v":6.63279E-10,"d":"6.63E-10"},{"v":1.37119e-09,"d":"1.37E-09"},"down","yes","Chrna7","protein_coding","chr1:116714711-116837240:-","gi|144922602|ref|NP_036964.3|",2475,0,"neuronal acetylcholine receptor subunit alpha-7 precursor [Rattus norvegicus]","gi|3478618|gb|L31619.1|RATNARAD",2080,0,"Rattus rattus nicotinic acetylcholine receptor alpha 7 subunit mRNA, complete cds","Q05941",954,0,"Neuronal acetylcholine receptor subunit alpha-7",".",".",".",".","pfam02931","Neur_chan_LBD","Neurotransmitter-gated ion-channel ligand binding domain. This family is the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.","GO:0001666|response to hypoxia;GO:0001933|negative regulation of protein phosphorylation;GO:0001934|positive regulation of protein phosphorylation;GO:0001988|positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure;GO:0006811|ion transport;GO:0006816|calcium ion transport;GO:0006874|cellular calcium ion homeostasis;GO:0006897|endocytosis;GO:0007165|signal transduction;GO:0007268|chemical synaptic transmission;GO:0007271|synaptic transmission, cholinergic;GO:0007611|learning or memory;GO:0007613|memory;GO:0008284|positive regulation of cell proliferation;GO:0008306|associative learning;GO:0009409|response to cold;GO:0014061|regulation of norepinephrine secretion;GO:0019228|neuronal action potential;GO:0030317|flagellated sperm motility;GO:0032094|response to food;GO:0032225|regulation of synaptic transmission, dopaminergic;GO:0032691|negative regulation of interleukin-1 beta production;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0034220|ion transmembrane transport;GO:0035094|response to nicotine;GO:0035095|behavioral response to nicotine;GO:0042110|T cell activation;GO:0042113|B cell activation;GO:0042391|regulation of membrane potential;GO:0042416|dopamine biosynthetic process;GO:0042698|ovulation cycle;GO:0043410|positive regulation of MAPK cascade;GO:0045471|response to ethanol;GO:0045766|positive regulation of angiogenesis;GO:0048149|behavioral response to ethanol;GO:0050727|regulation of inflammatory response;GO:0050728|negative regulation of inflammatory response;GO:0050804|modulation of chemical synaptic transmission;GO:0050808|synapse organization;GO:0050877|nervous system process;GO:0050890|cognition;GO:0050893|sensory processing;GO:0051247|positive regulation of protein metabolic process;GO:0060079|excitatory postsynaptic potential;GO:0060112|generation of ovulation cycle rhythm;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0095500|acetylcholine receptor signaling pathway;GO:0097061|dendritic spine organization;GO:0098815|modulation of excitatory postsynaptic potential;GO:0140059|dendrite arborization;GO:1900273|positive regulation of long-term synaptic potentiation;GO:1901214|regulation of neuron death;GO:1902004|positive regulation of amyloid-beta formation;GO:1902430|negative regulation of amyloid-beta formation;GO:1902991|regulation of amyloid precursor protein catabolic process;GO:1904645|response to amyloid-beta;GO:1905144|response to acetylcholine;GO:1905906|regulation of amyloid fibril formation;GO:1905920|positive regulation of CoA-transferase activity;GO:2000300|regulation of synaptic vesicle exocytosis;GO:2000463|positive regulation of excitatory postsynaptic potential;GO:2001023|regulation of response to drug;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005892|acetylcholine-gated channel complex;GO:0009897|external side of plasma membrane;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0030426|growth cone;GO:0030673|axolemma;GO:0032279|asymmetric synapse;GO:0042734|presynaptic membrane;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043197|dendritic spine;GO:0043198|dendritic shaft;GO:0044853|plasma membrane raft;GO:0045121|membrane raft;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0098690|glycinergic synapse;GO:0098981|cholinergic synapse;GO:0099055|integral component of postsynaptic membrane;GO:0099056|integral component of presynaptic membrane;GO:0099060|integral component of postsynaptic specialization membrane;GO:0099065|integral component of spine apparatus membrane;","GO:0001540|amyloid-beta binding;GO:0004888|transmembrane signaling receptor activity;GO:0005216|ion channel activity;GO:0005515|protein binding;GO:0008179|adenylate cyclase binding;GO:0015464|acetylcholine receptor activity;GO:0015643|toxic substance binding;GO:0017081|chloride channel regulator activity;GO:0019901|protein kinase binding;GO:0022848|acetylcholine-gated cation-selective channel activity;GO:0030594|neurotransmitter receptor activity;GO:0042166|acetylcholine binding;GO:0042803|protein homodimerization activity;GO:0051117|ATPase binding;GO:0097110|scaffold protein binding;GO:1904315|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K04809","CHRNA7; nicotinic acetylcholine receptor alpha-7"]
["ENSRNOG00000036897",66,5.479759595,193,12.41577457,0.44135463,-1.179989762,{"v":6.86427e-10,"d":"6.86E-10"},{"v":1.41629e-09,"d":"1.42E-09"},"down","yes","Defb24","protein_coding","chr3:141046564-141052753:-","gi|82775357|ref|NP_001032597.1|",296,{"v":5e-32,"d":"5.00E-32"},"beta-defensin 119 precursor [Rattus norvegicus]","gi|82775356|ref|NM_001037508.1|",240,{"v":4e-121,"d":"4.00E-121"},"Rattus norvegicus defensin beta 24 (Defb24), mRNA","Q8K3I8",107,{"v":3e-29,"d":"3.00E-29"},"Beta-defensin 19",".",".",".",".","pfam13841","Defensin_beta_2","Beta defensin. The beta defensins are antimicrobial peptides implicated in the resistance of epithelial surfaces to microbial colonisation.","GO:0045087|innate immune response;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:0061760|antifungal innate immune response;",".","GO:0001530|lipopolysaccharide binding;","K25606","DEFB; defensin, beta"]
["ENSRNOG00000009700",8,0.664213284,64,4.117148044,0.161328492,-2.631926844,{"v":7.22033e-10,"d":"7.22E-10"},{"v":1.48592E-9,"d":"1.49E-09"},"down","yes","Dync1i1","protein_coding","chr4:33852927-34166149:+","gi|149064952|gb|EDM15028.1|",3249,0,"dynein cytoplasmic 1 intermediate chain 1, isoform CRA_c [Rattus norvegicus]","gi|11276090|ref|NM_019234.1|",2626,0,"Rattus norvegicus dynein cytoplasmic 1 intermediate chain 1 (Dync1i1), mRNA","Q63100",1249,0,"Cytoplasmic dynein 1 intermediate chain 1",".",".",".",".","pfam11540","Dynein_IC2","Cytoplasmic dynein 1 intermediate chain 2. Intermediate chain IC 2 forms part of the complex cytoplasmic dynein 1 along with a heavy chain (HC), two light intermediate chains (LICs) and three light chains (LCs). The complex is responsible for hydrolysing ATP to generate force toward the minus end of microtubules. IC binds to the HC via the N terminal binding domain on the HC and ICs contain binding sites for the LCs. The ICs are responsible for binding to kinetochores and the Golgi apparatus through an interaction with the p150Glued subunit of dynactin which is another complex.","GO:0007018|microtubule-based movement;GO:0007420|brain development;GO:0010970|transport along microtubule;GO:0047496|vesicle transport along microtubule;GO:0075733|intracellular transport of virus;","GO:0000776|kinetochore;GO:0000922|spindle pole;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005868|cytoplasmic dynein complex;GO:0005874|microtubule;GO:0031982|vesicle;GO:0036464|cytoplasmic ribonucleoprotein granule;GO:0048471|perinuclear region of cytoplasm;GO:0055037|recycling endosome;GO:1904115|axon cytoplasm;GO:1990257|piccolo-bassoon transport vesicle;","GO:0003777|microtubule motor activity;GO:0005515|protein binding;GO:0008017|microtubule binding;GO:0030507|spectrin binding;GO:0045503|dynein light chain binding;GO:0045504|dynein heavy chain binding;","K10415","DYNC1I, DNCI; dynein cytoplasmic 1 intermediate chain"]
["ENSRNOG00000015695",89,7.389372787,236,15.18198341,0.486719856,-1.038836462,{"v":7.52832e-10,"d":"7.53E-10"},{"v":1.54582e-09,"d":"1.55E-09"},"down","yes","Sult5a1","protein_coding","chr19:51189287-51204362:-","gi|318104594|ref|NP_001188298.1|",1625,0,"sulfotransferase family 5A, member 1 isoform 1 [Rattus norvegicus]","gi|318104593|ref|NM_001201369.1|",1045,0,"Rattus norvegicus sulfotransferase family 5A, member 1 (Sult5a1), transcript variant 1, mRNA","O35400",238,{"v":1e-72,"d":"1.00E-72"},"Sulfotransferase family cytosolic 2B member 1",".",".",".",".","pfam00685","Sulfotransfer_1","Sulfotransferase domain.","GO:0051923|sulfation;","GO:0005737|cytoplasm;","GO:0008146|sulfotransferase activity;",".","."]
["ENSRNOG00000013496",4,0.332106642,51,3.280852347,0.10122572,-3.304352186,{"v":7.96456e-10,"d":"7.96E-10"},{"v":1.6312e-09,"d":"1.63E-09"},"down","yes","Crisp3","protein_coding","chr9:20450908-20472658:+","gi|12408314|ref|NP_074050.1|",1130,{"v":2e-153,"d":"2.00E-153"},"cysteine-rich secretory protein 1 precursor [Rattus norvegicus]","gi|56112|emb|X04643.1|",864,0,"Rat mRNA for epididymal secretory glycoproteins","P12020",439,{"v":7e-155,"d":"7.00E-155"},"Cysteine-rich secretory protein 1",".",".",".",".","pfam08562","Crisp","Crisp. This domain is found on Crisp proteins which contain pfam00188 and has been termed the Crisp domain. It is found in the mammalian reproductive tract and the venom of reptiles, and has been shown to regulate ryanodine receptor Ca2+ signalling. It contains 10 conserved cysteines which are all involved in disulphide bonds and is structurally related to the ion channel inhibitor toxins BgK and ShK.",".","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0042581|specific granule;",".",".","."]
["ENSRNOG00000033528",4,0.332106642,51,3.280852347,0.10122572,-3.304352186,{"v":7.96456e-10,"d":"7.96E-10"},{"v":1.6312e-09,"d":"1.63E-09"},"down","yes","Tll1","protein_coding","chr16:25509146-25709543:+","gi|157823867|ref|NP_001099551.1|",5487,0,"tolloid-like protein 1 precursor [Rattus norvegicus]","gi|157823866|ref|NM_001106081.1|",4721,0,"Rattus norvegicus tolloid-like 1 (Tll1), mRNA","Q62381",2086,0,"Tolloid-like protein 1",".",".",".",".","pfam01400","Astacin","Astacin (Peptidase family M12A). The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family contain two conserved disulphide bridges, these are joined 1-4 and 2-3. Members of this family have an amino terminal propeptide which is cleaved to give the active protease domain. All other linked domains are found to the carboxyl terminus of this domain. This family includes: Astacin, a digestive enzyme from Crayfish. Meprin, a multiple domain membrane component that is constructed from a homologous alpha and beta chain. Proteins involved in morphogenesis, and Tolloid from drosophila.","GO:0006508|proteolysis;GO:0030154|cell differentiation;",".","GO:0004222|metalloendopeptidase activity;GO:0005509|calcium ion binding;GO:0005518|collagen binding;GO:0008270|zinc ion binding;","K09608","TLL1; tolloid-like protein 1 [EC:3.4.24.-]"]
["ENSRNOG00000016603",64,5.313706274,188,12.09412238,0.439362701,-1.186515695,{"v":9.62531e-10,"d":"9.63E-10"},{"v":1.95754e-09,"d":"1.96E-09"},"down","yes","Rtn2","protein_coding","chr1:78935104-78948069:+","gi|42476339|ref|NP_963856.1|",2098,0,"reticulon-2 [Rattus norvegicus]","gi|42521116|tpg|BK001788.2|",1961,0,"TPA_inf: Rattus norvegicus RTN2-B (Rtn2) mRNA, complete cds","O70622",758,0,"Reticulon-2",".",".",".",".","pfam02453","Reticulon","Reticulon. Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of unknown function which associates with the endoplasmic reticulum. This family represents the C-terminal domain of the three reticulon isoforms and their homologues.","GO:0010467|gene expression;GO:0015031|protein transport;GO:0046324|regulation of glucose import;GO:0065002|intracellular protein transmembrane transport;GO:1902430|negative regulation of amyloid-beta formation;","GO:0005783|endoplasmic reticulum;GO:0005882|intermediate filament;GO:0009986|cell surface;GO:0014802|terminal cisterna;GO:0016021|integral component of membrane;GO:0030018|Z disc;GO:0030315|T-tubule;GO:0033017|sarcoplasmic reticulum membrane;","GO:0005515|protein binding;","K20722","RTN2; reticulon-2"]
["ENSRNOG00000016222",10,0.830266605,69,4.438800235,0.187047527,-2.418523206,{"v":1.06016E-9,"d":"1.06E-09"},{"v":2.14995E-9,"d":"2.15E-09"},"down","yes","Ppp1r3g","protein_coding","chr17:28876482-28877525:-","gi|564319774|ref|XP_006222440.1|",1534,0,"PREDICTED: protein phosphatase 1 regulatory subunit 3G [Rattus norvegicus]","gi|564319773|ref|XM_006222378.1|",1044,0,"PREDICTED: Rattus norvegicus protein phosphatase 1, regulatory subunit 3G (Ppp1r3g), mRNA","Q9CW07",526,0,"Protein phosphatase 1 regulatory subunit 3G",".",".",".",".","pfam03370","CBM_21","Putative phosphatase regulatory subunit. This family consists of several eukaryotic proteins that are thought to be involved in the regulation of glycogen metabolizm. For instance, the mouse PTG protein has been shown to interact with glycogen synthase, phosphorylase kinase, phosphorylase a: these three enzymes have key roles in the regulation of glycogen metabolizm. PTG also binds the catalytic subunit of protein phosphatase 1 (PP1C) and localizes it to glycogen. Subsets of similar interactions have been observed with several other members of this family, such as the yeast PIG1, PIG2, GAC1 and GIP2 proteins. While the precise function of these proteins is not known, they may serve a scaffold function, bringing together the key enzymes in glycogen metabolizm. This family is a carbohydrate binding domain.","GO:0005979|regulation of glycogen biosynthetic process;GO:0042593|glucose homeostasis;GO:0045725|positive regulation of glycogen biosynthetic process;GO:2000467|positive regulation of glycogen (starch) synthase activity;","GO:0000164|protein phosphatase type 1 complex;GO:0005737|cytoplasm;","GO:0008157|protein phosphatase 1 binding;GO:0019903|protein phosphatase binding;GO:2001069|glycogen binding;",".","."]
["ENSRNOG00000037348",6,0.498159963,57,3.666834977,0.135855572,-2.879854357,{"v":1.09667e-09,"d":"1.10E-09"},{"v":2.21976e-09,"d":"2.22E-09"},"down","yes","AABR07003187.1","protein_coding","chr1:93693837-93694943:-","gi|56090375|ref|NP_001007742.1|",1686,0,"interferon-stimulated 20 kDa exonuclease-like 2 [Rattus norvegicus]","gi|56090374|ref|NM_001007741.1|",1066,0,"Rattus norvegicus interferon stimulated exonuclease gene 20-like 2 (Isg20l2), mRNA","Q6AXU3",654,0,"Interferon-stimulated 20 kDa exonuclease-like 2","YOL080c",139,{"v":4e-37,"d":"4.00E-37"},"COG0847","pfam00929","RNase_T","Exonuclease. This family includes a variety of exonuclease proteins, such as ribonuclease T and the epsilon subunit of DNA polymerase III.;",".",".",".",".","."]
["ENSRNOG00000004265",9,0.747239945,66,4.24580892,0.175994718,-2.506395962,{"v":1.13388E-9,"d":"1.13E-09"},{"v":2.29144e-09,"d":"2.29E-09"},"down","yes","Dipk2b","protein_coding","chrX:4205490-4271574:+","gi|589962887|ref|XP_006993995.1|",1913,0,"PREDICTED: deleted in autism-related protein 1 homolog [Peromyscus maniculatus bairdii]","gi|672086942|ref|XM_008773060.1|",2013,0,"PREDICTED: Rattus norvegicus similar to RIKEN cDNA 4930578C19 (RGD1559731), transcript variant X3, partial mRNA","Q8C3I9",734,0,"Deleted in autism-related protein 1 homolog",".",".",".",".","pfam12260","PIP49_C","Protein-kinase domain of FAM69. This is the C-terminal region of a family of FAM69 proteins from Metazoa and Viridiplantae that are active protein-kinases. The family members have a short transmembrane helix close to the N-terminus, and thereafter are highly enriched with cysteines. FAM69 proteins are localized to the endoplasmic reticulum. Many members also have a short EF-hand, calcium-binding, domain just upstream of the kinase domain. The exact function of the more N-terminal family is uncertain.",".","GO:0005576|extracellular region;",".",".","."]
["ENSRNOG00000009311",63,5.230679613,185,11.90113106,0.439511134,-1.186028381,{"v":1.32338E-9,"d":"1.32E-09"},{"v":2.66346e-09,"d":"2.66E-09"},"down","yes","Fstl3","protein_coding","chr7:9923576-9939639:-","gi|16758958|ref|NP_446081.1|",1028,{"v":7e-132,"d":"7.00E-132"},"follistatin-related protein 3 precursor [Rattus norvegicus]","gi|23095928|dbj|AB071603.1|",1758,0,"Rattus norvegicus flrg mRNA for follistatin-like protein, complete cds","Q99PW7",400,{"v":2e-133,"d":"2.00E-133"},"Follistatin-related protein 3",".",".",".",".","pfam07648","Kazal_2","Kazal-type serine protease inhibitor domain. Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.","GO:0001503|ossification;GO:0001822|kidney development;GO:0002244|hematopoietic progenitor cell differentiation;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007275|multicellular organism development;GO:0007283|spermatogenesis;GO:0008584|male gonad development;GO:0022409|positive regulation of cell-cell adhesion;GO:0030154|cell differentiation;GO:0030324|lung development;GO:0030325|adrenal gland development;GO:0030510|regulation of BMP signaling pathway;GO:0030514|negative regulation of BMP signaling pathway;GO:0032926|negative regulation of activin receptor signaling pathway;GO:0045671|negative regulation of osteoclast differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0071248|cellular response to metal ion;GO:0090101|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005794|Golgi apparatus;GO:0030141|secretory granule;GO:0044306|neuron projection terminus;","GO:0001968|fibronectin binding;GO:0048185|activin binding;","K23913","FSTL3; follistatin-related protein 3"]
["ENSRNOG00000009439",25,2.075666513,106,6.819026448,0.304393381,-1.715991109,{"v":1.36984e-09,"d":"1.37E-09"},{"v":2.75351e-09,"d":"2.75E-09"},"down","yes","Eef1a1","protein_coding","chr8:79341557-79344839:-","gi|965955645|ref|XP_014953624.1|",2167,0,"PREDICTED: elongation factor 1-alpha 1-like [Ovis aries]","gi|118764357|gb|BC128723.1|",1341,0,"Rattus norvegicus eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:156575 IMAGE:7312569), complete cds","P62630",800,0,"Elongation factor 1-alpha 1","SPCC794.09c",662,0,"COG5256","pfam00009","GTP_EFTU","Elongation factor Tu GTP binding domain. This domain contains a P-loop motif, also found in several other families such as pfam00071, pfam00025 and pfam00063. Elongation factor Tu consists of three structural domains, this plus two C-terminal beta barrel domains.","GO:0006412|translation;GO:0006414|translational elongation;GO:0007568|aging;GO:0010942|positive regulation of cell death;GO:0010976|positive regulation of neuron projection development;GO:0071364|cellular response to epidermal growth factor stimulus;GO:0071466|cellular response to xenobiotic stimulus;GO:1900022|regulation of D-erythro-sphingosine kinase activity;GO:1903427|negative regulation of reactive oxygen species biosynthetic process;GO:1990090|cellular response to nerve growth factor stimulus;","GO:0005634|nucleus;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005765|lysosomal membrane;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0030864|cortical actin cytoskeleton;GO:0032587|ruffle membrane;","GO:0000049|tRNA binding;GO:0003729|mRNA binding;GO:0003746|translation elongation factor activity;GO:0003924|GTPase activity;GO:0005516|calmodulin binding;GO:0005525|GTP binding;GO:0019900|kinase binding;GO:0019901|protein kinase binding;GO:0042802|identical protein binding;GO:1901363|heterocyclic compound binding;","K03231","EEF1A; elongation factor 1-alpha"]
["ENSRNOG00000055383",22,1.826586532,99,6.36871338,0.286806208,-1.801851845,{"v":1.38094E-9,"d":"1.38E-09"},{"v":2.77319E-9,"d":"2.77E-09"},"down","yes","AABR07067762.1","protein_coding","chr9:56634648-56635789:+","gi|126723054|ref|NP_598282.2|",573,{"v":4e-72,"d":"4.00E-72"},"glycine cleavage system H protein, mitochondrial precursor [Rattus norvegicus]","gi|32362328|gb|AC103419.6|",350,0,"Rattus norvegicus 9 BAC CH230-145A24 (Children's Hospital Oakland Research Institute) complete sequence","Q5I0P2",225,{"v":1E-73,"d":"1.00E-73"},"Glycine cleavage system H protein, mitochondrial","TM0212",92.4,{"v":4e-23,"d":"4.00E-23"},"COG0509","pfam01597","GCV_H","Glycine cleavage H-protein. This is a family of glycine cleavage H-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyses the catabolism of glycine in eukaryotes. A lipoyl group is attached to a completely conserved lysine residue. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.",".",".",".",".","."]
["ENSRNOG00000058870",70,5.811866237,198,12.73742676,0.456282603,-1.132000447,{"v":1.49856E-9,"d":"1.50E-09"},{"v":3.00375e-09,"d":"3.00E-09"},"down","yes","Mroh7","protein_coding","chr5:121463827-121503755:-","gi|155369285|ref|NP_001094435.1|",5360,0,"maestro heat-like repeat-containing protein family member 7 [Rattus norvegicus]","gi|402693335|ref|NM_001100965.2|",4160,0,"Rattus norvegicus maestro heat-like repeat family member 7 (Mroh7), mRNA","A2RUW0",2069,0,"Maestro heat-like repeat-containing protein family member 7",".",".",".",".","pfam10468","Inhibitor_I68","Carboxypeptidase inhibitor I68. This is a family of tick carboxypetidase inhibitors.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000043199",37,3.071986439,132,8.49161784,0.361766921,-1.466867598,{"v":1.59221E-9,"d":"1.59E-09"},{"v":3.18248E-9,"d":"3.18E-09"},"down","yes","Bves","protein_coding","chr20:48822308-48857472:+","gi|117606391|ref|NP_001071058.1|",1849,0,"blood vessel epicardial substance [Rattus norvegicus]","gi|117606390|ref|NM_001077590.1|",1471,0,"Rattus norvegicus blood vessel epicardial substance (Bves), mRNA","Q3BCU4",716,0,"Blood vessel epicardial substance",".",".",".",".","pfam04831","Popeye","Popeye protein conserved region. The function of Popeye proteins is not well understood. They are predominantly expressed in cardiac and skeletal muscle. This family represents a conserved region which includes three potential transmembrane domains.","GO:0001921|positive regulation of receptor recycling;GO:0002027|regulation of heart rate;GO:0002244|hematopoietic progenitor cell differentiation;GO:0002931|response to ischemia;GO:0007507|heart development;GO:0007519|skeletal muscle tissue development;GO:0008360|regulation of cell shape;GO:0016192|vesicle-mediated transport;GO:0034446|substrate adhesion-dependent cell spreading;GO:0040017|positive regulation of locomotion;GO:0042391|regulation of membrane potential;GO:0043087|regulation of GTPase activity;GO:0048278|vesicle docking;GO:0051146|striated muscle cell differentiation;GO:0060931|sinoatrial node cell development;GO:0060973|cell migration involved in heart development;GO:0090136|epithelial cell-cell adhesion;GO:2001135|regulation of endocytic recycling;","GO:0005886|plasma membrane;GO:0005901|caveola;GO:0005923|bicellular tight junction;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016328|lateral plasma membrane;GO:0030054|cell junction;GO:0031253|cell projection membrane;GO:0042383|sarcolemma;","GO:0005198|structural molecule activity;GO:0030552|cAMP binding;","K21108","BVES; blood vessel epicardial substance"]
["ENSRNOG00000028624",41,3.404093082,140,9.006261346,0.377969609,-1.403657856,{"v":1.82562e-09,"d":"1.83E-09"},{"v":3.63311e-09,"d":"3.63E-09"},"down","yes","Kif26b","protein_coding","chr13:90283404-90682811:+","gi|239582739|ref|NP_001102549.2|",9223,0,"kinesin-like protein KIF26B [Rattus norvegicus]","gi|239582738|ref|NM_001109079.2|",7421,0,"Rattus norvegicus kinesin family member 26B (Kif26b), mRNA","Q7TNC6",3362,0,"Kinesin-like protein KIF26B","YGL216w",106,{"v":5e-22,"d":"5.00E-22"},"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0022409|positive regulation of cell-cell adhesion;GO:0030010|establishment of cell polarity;GO:0072092|ureteric bud invasion;","GO:0005871|kinesin complex;GO:0005874|microtubule;","GO:0003777|microtubule motor activity;GO:0005524|ATP binding;GO:0008017|microtubule binding;","K10404","KIF26; kinesin family member 26"]
["ENSRNOG00000046132",8,0.664213284,62,3.988487167,0.166532637,-2.586123154,{"v":1.90041e-09,"d":"1.90E-09"},{"v":3.77725E-9,"d":"3.78E-09"},"down","yes","AABR07024439.1","protein_coding","chr16:35586200-35651524:-","gi|672063869|ref|XP_008764956.1|",734,{"v":2e-94,"d":"2.00E-94"},"PREDICTED: disks large homolog 5-like isoform X1 [Rattus norvegicus]","gi|672087250|ref|XR_597568.1|",196,{"v":2e-96,"d":"2.00E-96"},"PREDICTED: Rattus norvegicus hypothetical protein LOC680236 (LOC680236), transcript variant X3, misc_RNA",".",".",".",".",".",".",".",".","pfam04822","Takusan","Takusan. This domain is named takusan, which is a Japanese word meaning 'many'. Members of this family regulate synaptic activity.",".",".",".",".","."]
["ENSRNOG00000008966",25,2.075666513,105,6.754696009,0.307292365,-1.702316172,{"v":2.0165e-09,"d":"2.02E-09"},{"v":4.00301e-09,"d":"4.00E-09"},"down","yes","Slco5a1","protein_coding","chr5:6228973-6352913:+","gi|564349979|ref|XP_006237805.1|",4201,0,"PREDICTED: solute carrier organic anion transporter family member 5A1 isoform X1 [Rattus norvegicus]","gi|157821922|ref|NM_001107898.1|",3177,0,"Rattus norvegicus solute carrier organic anion transporter family, member 5A1 (Slco5a1), mRNA","Q9H2Y9",1399,0,"Solute carrier organic anion transporter family member 5A1",".",".",".",".","pfam03137","OATP","Organic Anion Transporter Polypeptide (OATP) family. This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.","GO:0043252|sodium-independent organic anion transport;GO:0055085|transmembrane transport;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0015347|sodium-independent organic anion transmembrane transporter activity;","K14356","SLCO5A; solute carrier organic anion transporter family, member 5A"]
["ENSRNOG00000035606",26,2.158693174,107,6.883356886,0.313610526,-1.672954112,{"v":2.24169e-09,"d":"2.24E-09"},{"v":4.43902e-09,"d":"4.44E-09"},"down","yes","Mir3554","miRNA","chr5:103599032-103599149:+",".",".",".",".","gi|312147245|ref|NR_037332.1|",118,{"v":6e-54,"d":"6.00E-54"},"Rattus norvegicus microRNA 3554 (Mir3554), microRNA",".",".",".",".",".",".",".",".","pfam07817","GLE1","GLE1-like protein. The members of this family are sequences that are similar to the human protein GLE1. This protein is localized at the nuclear pore complexes and functions in poly(A)+ RNA export to the cytoplasm.",".",".",".",".","."]
["ENSRNOG00000007069",79,6.559106181,213,13.70238333,0.4786836,-1.062855716,{"v":2.56417e-09,"d":"2.56E-09"},{"v":5.05567e-09,"d":"5.06E-09"},"down","yes","Adhfe1","protein_coding","chr5:9705970-9732517:-","gi|70794742|ref|NP_001020594.1|",2309,0,"hydroxyacid-oxoacid transhydrogenase, mitochondrial [Rattus norvegicus]","gi|672051852|ref|XM_008763508.1|",1733,0,"PREDICTED: Rattus norvegicus alcohol dehydrogenase, iron containing, 1 (Adhfe1), transcript variant X2, mRNA","Q4QQW3",894,0,"Hydroxyacid-oxoacid transhydrogenase, mitochondrial","TVN1284",315,{"v":3e-99,"d":"3.00E-99"},"COG1454","pfam00465","Fe-ADH","Iron-containing alcohol dehydrogenase.","GO:0006539|glutamate catabolic process via 2-oxoglutarate;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005739|mitochondrion;","GO:0003674|molecular_function;GO:0004022|alcohol dehydrogenase (NAD) activity;GO:0046872|metal ion binding;GO:0047988|hydroxyacid-oxoacid transhydrogenase activity;","K11173","ADHFE1; hydroxyacid-oxoacid transhydrogenase [EC:1.1.99.24]"]
["ENSRNOG00000022391",24,1.992639853,102,6.561704695,0.303677161,-1.719389685,{"v":2.65163e-09,"d":"2.65E-09"},{"v":5.22007e-09,"d":"5.22E-09"},"down","yes","ENSRNOG00000022391","protein_coding","chrX:77646558-77678045:+","gi|293351051|ref|XP_002727665.1|",4092,0,"PREDICTED: zinc finger protein 711 [Rattus norvegicus]","gi|672088039|ref|XM_002730265.4|",2528,0,"PREDICTED: Rattus norvegicus zinc finger protein 711 (Zfp711), transcript variant X3, mRNA","A2ANX9",1459,0,"Zinc finger protein 711","SPAC144.09c",85.5,{"v":6e-17,"d":"6.00E-17"},"COG5048","pfam04704","Zfx_Zfy_act","Zfx / Zfy transcription activation region. Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0045893|positive regulation of transcription, DNA-templated;","GO:0005634|nucleus;GO:0005694|chromosome;","GO:0043035|chromatin insulator sequence binding;GO:0043565|sequence-specific DNA binding;GO:0046872|metal ion binding;","K24376","ZNF711; zinc finger protein 711"]
["ENSRNOG00000000840",10,0.830266605,67,4.310139358,0.192631035,-2.376087939,{"v":2.69557E-9,"d":"2.70E-09"},{"v":5.29842e-09,"d":"5.30E-09"},"down","yes","Atp6v1g2","protein_coding","chr20:3587686-3590481:-","gi|47059104|ref|NP_997655.1|",303,{"v":3e-29,"d":"3.00E-29"},"V-type proton ATPase subunit G 2 [Rattus norvegicus]","gi|110350025|gb|AC130591.5|",1660,0,"Rattus norvegicus BAC CH230-312A21 () complete sequence","Q5WR09",117,{"v":2e-29,"d":"2.00E-29"},"V-type proton ATPase subunit G 1",".",".",".",".","pfam03179","V-ATPase_G","Vacuolar (H+)-ATPase G subunit. This family represents the eukaryotic vacuolar (H+)-ATPase (V-ATPase) G subunit. V-ATPases generate an acidic environment in several intracellular compartments. Correspondingly, they are found as membrane-attached proteins in several organelles. They are also found in the plasma membranes of some specialized cells. V-ATPases consist of peripheral (V1) and membrane integral (V0) heteromultimeric complexes. The G subunit is part of the V1 subunit, but is also thought to be strongly attached to the V0 complex. It may be involved in the coupling of ATP degradation to H+ translocation.","GO:1902600|proton transmembrane transport;","GO:0016471|vacuolar proton-transporting V-type ATPase complex;GO:0030285|integral component of synaptic vesicle membrane;","GO:0008553|proton-exporting ATPase activity, phosphorylative mechanism;GO:0016887|ATPase activity;GO:0046961|proton-transporting ATPase activity, rotational mechanism;","K02152","ATPeV1G, ATP6G; V-type H+-transporting ATPase subunit G"]
["ENSRNOG00000030788",5,0.415133303,52,3.345182786,0.12409884,-3.010438467,{"v":2.69744e-09,"d":"2.70E-09"},{"v":5.30046e-09,"d":"5.30E-09"},"down","yes","Olr35","protein_coding","chr1:154041306-154043257:+","gi|47577201|ref|NP_001000121.1|",1277,{"v":2E-171,"d":"2.00E-171"},"olfactory receptor Olr35 [Rattus norvegicus]","gi|51372035|gb|AC115040.7|",967,0,"Mus musculus chromosome 7, clone RP24-281E19, complete sequence","A6NND4",433,{"v":3E-148,"d":"3.00E-148"},"Olfactory receptor 2AT4",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0050911|detection of chemical stimulus involved in sensory perception of smell;GO:0070374|positive regulation of ERK1 and ERK2 cascade;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004984|olfactory receptor activity;","K04257","OLFR; olfactory receptor"]
["ENSRNOG00000022796",34,2.822906458,124,7.976974335,0.353881853,-1.498660313,{"v":2.79943e-09,"d":"2.80E-09"},{"v":5.4958E-9,"d":"5.50E-09"},"down","yes","Fgfbp3","protein_coding","chr1:234644019-234646547:-","gi|157821225|ref|NP_001102635.1|",917,{"v":9e-115,"d":"9.00E-115"},"fibroblast growth factor-binding protein 3 precursor [Rattus norvegicus]","gi|157821224|ref|NM_001109165.1|",1722,0,"Rattus norvegicus fibroblast growth factor binding protein 3 (Fgfbp3), mRNA","Q1HCM0",297,{"v":2e-93,"d":"2.00E-93"},"Fibroblast growth factor-binding protein 3",".",".",".",".","pfam06473","FGF-BP1","FGF binding protein 1 (FGF-BP1). This family consists of several mammalian FGF binding protein 1. Fibroblast growth factors (FGFs) play important roles during fetal and embryonic development. Fibroblast growth factor-binding protein (FGF-BP) 1 is a secreted protein that can bind fibroblast growth factors (FGFs) 1 and 2.","GO:0007267|cell-cell signaling;GO:0030534|adult behavior;GO:0031646|positive regulation of neurological system process;GO:0043117|positive regulation of vascular permeability;GO:0045743|positive regulation of fibroblast growth factor receptor signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;","GO:0005576|extracellular region;","GO:0008201|heparin binding;GO:0017134|fibroblast growth factor binding;GO:0019838|growth factor binding;","K25535","FGFBP; fibroblast growth factor-binding protein"]
["ENSRNOG00000020165",1,0.083026661,37,2.380226213,0.034881836,-4.841380209,{"v":4.19941e-09,"d":"4.20E-09"},{"v":8.12942e-09,"d":"8.13E-09"},"down","yes","Ahsp","protein_coding","chr1:182880076-182885506:+","gi|157820931|ref|NP_001099769.1|",469,{"v":9e-56,"d":"9.00E-56"},"alpha-hemoglobin-stabilizing protein [Rattus norvegicus]","gi|157820930|ref|NM_001106299.1|",499,0,"Rattus norvegicus alpha hemoglobin stabilizing protein (Ahsp), mRNA","Q9CY02",153,{"v":7E-45,"d":"7.00E-45"},"Alpha-hemoglobin-stabilizing protein",".",".",".",".","pfam09236","AHSP","Alpha-haemoglobin stabilizing protein. Alpha-haemoglobin stabilizing protein (AHSP) acts a molecular chaperone for free alpha-haemoglobin, preventing the harmful aggregation of alpha-haemoglobin during normal erythroid cell development: it specifically protects free alpha-haemoglobin from precipitation. AHSP adopts a helical secondary structure consisting of an elongated antiparallel three alpha-helix bundle.","GO:0006457|protein folding;GO:0008150|biological_process;GO:0030218|erythrocyte differentiation;GO:0050821|protein stabilization;","GO:0005575|cellular_component;GO:0005737|cytoplasm;","GO:0003674|molecular_function;GO:0030492|hemoglobin binding;",".","."]
["ENSRNOG00000008423",13,1.079346587,74,4.760452426,0.226731934,-2.140940491,{"v":4.41758e-09,"d":"4.42E-09"},{"v":8.53626e-09,"d":"8.54E-09"},"down","yes","Gpr22","protein_coding","chr6:48310505-48317486:-","gi|26339128|dbj|BAC33235.1|",2268,0,"unnamed protein product [Mus musculus]","gi|157818248|ref|NM_001106722.1|",4531,0,"Rattus norvegicus G protein-coupled receptor 22 (Gpr22), mRNA","Q8BZL4",769,0,"Probable G-protein coupled receptor 22",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0030030|cell projection organization;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0042277|peptide binding;","K04319","GPR22; G protein-coupled receptor 22"]
["ENSRNOG00000017510",5,0.415133303,51,3.280852347,0.12653215,-2.982424091,{"v":4.48798e-09,"d":"4.49E-09"},{"v":8.66444e-09,"d":"8.66E-09"},"down","yes","Mfge8","protein_coding","chr1:133064665-133080073:-","gi|93277126|ref|NP_001035276.1|",2309,0,"lactadherin isoform 1 precursor [Rattus norvegicus]","gi|403310694|ref|NM_001040186.2|",2150,0,"Rattus norvegicus milk fat globule-EGF factor 8 protein (Mfge8), transcript variant 1, mRNA","P21956",824,0,"Lactadherin",".",".",".",".","pfam00754","F5_F8_type_C","F5/8 type C domain. This domain is also known as the discoidin (DS) domain family.","GO:0001525|angiogenesis;GO:0006910|phagocytosis, recognition;GO:0006911|phagocytosis, engulfment;GO:0007155|cell adhesion;GO:0007338|single fertilization;GO:0008284|positive regulation of cell proliferation;GO:0043277|apoptotic cell clearance;GO:0043627|response to estrogen;GO:0050766|positive regulation of phagocytosis;","GO:0002080|acrosomal membrane;GO:0005615|extracellular space;GO:0009897|external side of plasma membrane;GO:0019897|extrinsic component of plasma membrane;","GO:0001786|phosphatidylserine binding;GO:0005178|integrin binding;GO:0008429|phosphatidylethanolamine binding;","K17253","MFGE8; lactadherin"]
["ENSRNOG00000042152",77,6.39305286,207,13.3164007,0.480088652,-1.058627261,{"v":4.80664e-09,"d":"4.81E-09"},{"v":9.23501e-09,"d":"9.24E-09"},"down","yes","Gipc2","protein_coding","chr2:241030770-241110236:-","gi|81295361|ref|NP_001032287.1|",1573,0,"PDZ domain-containing protein GIPC2 [Rattus norvegicus]","gi|81295360|ref|NM_001037210.1|",1253,0,"Rattus norvegicus GIPC PDZ domain containing family, member 2 (Gipc2), mRNA","Q498D9",585,0,"PDZ domain-containing protein GIPC2",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.",".","GO:0005737|cytoplasm;","GO:0042802|identical protein binding;","K20056","GIPC, SEMCAP; PDZ domain-containing protein GIPC"]
["ENSRNOG00000053190",75,6.226999539,203,13.05907895,0.476832981,-1.068444071,{"v":5.19792e-09,"d":"5.20E-09"},{"v":9.95389e-09,"d":"9.95E-09"},"down","yes","AABR07012635.1","protein_coding","chr2:186188624-186202949:+","gi|37654274|gb|AAQ96242.1|",213,{"v":1e-20,"d":"1.00E-20"},"LRRGT00029 [Rattus norvegicus]","gi|37654273|gb|AY383684.1|",228,{"v":1e-114,"d":"1.00E-114"},"Rattus norvegicus LRRGT00029 mRNA, complete cds",".",".",".",".",".",".",".",".","pfam11911","DUF3429","Protein of unknown function (DUF3429). This family of proteins are functionally uncharacterized. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 147 to 245 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000022635",12,0.996319926,71,4.567461111,0.218134299,-2.196711463,{"v":5.20199e-09,"d":"5.20E-09"},{"v":9.9587e-09,"d":"9.96E-09"},"down","yes","Dlg2","protein_coding","chr1:144451472-146499475:+","gi|589932495|ref|XP_006979045.1|",4423,0,"PREDICTED: disks large homolog 2-like isoform X2 [Peromyscus maniculatus bairdii]","gi|795347427|ref|XM_012075517.1|",2627,0,"PREDICTED: Cercocebus atys discs, large homolog 2 (Drosophila) (DLG2), transcript variant X14, mRNA","Q15700",1699,0,"Disks large homolog 2","YDR454c",102,{"v":1E-22,"d":"1.00E-22"},"COG0194","pfam00625","Guanylate_kin","Guanylate kinase.","GO:0007268|chemical synaptic transmission;GO:0009790|embryo development;GO:0019233|sensory perception of pain;GO:0035865|cellular response to potassium ion;GO:0043113|receptor clustering;GO:0045161|neuronal ion channel clustering;GO:0045197|establishment or maintenance of epithelial cell apical/basal polarity;GO:0097120|receptor localization to synapse;GO:0098609|cell-cell adhesion;GO:0099562|maintenance of postsynaptic density structure;GO:0099641|anterograde axonal protein transport;GO:0099642|retrograde axonal protein transport;GO:0099645|neurotransmitter receptor localization to postsynaptic specialization membrane;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0016323|basolateral plasma membrane;GO:0030054|cell junction;GO:0030425|dendrite;GO:0030672|synaptic vesicle membrane;GO:0031594|neuromuscular junction;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0044224|juxtaparanode region of axon;GO:0045211|postsynaptic membrane;GO:0098839|postsynaptic density membrane;GO:0098978|glutamatergic synapse;GO:0099031|anchored component of postsynaptic density membrane;GO:1904115|axon cytoplasm;","GO:0005515|protein binding;GO:0008022|protein C-terminus binding;GO:0019900|kinase binding;GO:0019903|protein phosphatase binding;GO:0030165|PDZ domain binding;GO:0044877|protein-containing complex binding;GO:0098919|structural constituent of postsynaptic density;","K12075","DLG2; discs large protein 2"]
["ENSRNOG00000028108",38,3.1550131,130,8.362956964,0.377260473,-1.406367143,{"v":6.53913e-09,"d":"6.54E-09"},{"v":1.24366e-08,"d":"1.24E-08"},"down","yes","Cytl1","protein_coding","chr14:73053877-73058886:-","gi|197384591|ref|NP_001128076.1|",634,{"v":6e-76,"d":"6.00E-76"},"cytokine-like protein 1 precursor [Rattus norvegicus]","gi|197384590|ref|NM_001134604.1|",1846,0,"Rattus norvegicus cytokine like 1 (Cytl1), mRNA","Q9NRR1",179,{"v":2E-51,"d":"2.00E-51"},"Cytokine-like protein 1",".",".",".",".","pfam15153","CYTL1","Cytokine-like protein 1. The function of this family of proteins, CYTL1, has not, as yet, been determined. However it is thought to be a secretory protein expressed in CD34+ haemopoietic cells. This family of proteins is found in eukaryotes. Proteins in this family are typically between 134 and 145 amino acids in length. There are two conserved sequence motifs: PPTCYSR and DDC.","GO:0002062|chondrocyte differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048839|inner ear development;GO:0050650|chondroitin sulfate proteoglycan biosynthetic process;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:1990079|cartilage homeostasis;",".",".","K25418","CYTL1; cytokine-like protein 1"]
["ENSRNOG00000018394",1,0.083026661,36,2.315895775,0.035850776,-4.801851845,{"v":7.10689e-09,"d":"7.11E-09"},{"v":1.34883e-08,"d":"1.35E-08"},"down","yes","Chrdl2","protein_coding","chr1:154343201-154370640:+","gi|157820135|ref|NP_001101007.1|",2210,0,"chordin-like protein 2 precursor [Rattus norvegicus]","gi|157820134|ref|NM_001107537.1|",1529,0,"Rattus norvegicus chordin-like 2 (Chrdl2), mRNA","Q8VEA6",817,0,"Chordin-like protein 2",".",".",".",".","pfam00093","VWC","von Willebrand factor type C domain. The high cutoff was used to prevent overlap with pfam00094.","GO:0030154|cell differentiation;GO:0030514|negative regulation of BMP signaling pathway;",".",".","K17280","CHRDL2; chordin-like protein 2"]
["ENSRNOG00000069674",52,4.317386347,158,10.16420923,0.424763624,-1.235267874,{"v":7.13898e-09,"d":"7.14E-09"},{"v":1.35452e-08,"d":"1.35E-08"},"down","yes","ENSRNOG00000069674","lncRNA","chr10:54884768-54921688:-","gi|74138308|dbj|BAE38023.1|",216,{"v":6e-17,"d":"6.00E-17"},"unnamed protein product [Mus musculus]","gi|47777619|gb|AC147563.4|",642,0,"Mus musculus BAC clone RP23-231H21 from chromosome 10, complete sequence",".",".",".",".",".",".",".",".","pfam15103","G0-G1_switch_2","G0/G1 switch protein 2. This family of proteins regulate apoptosis by binding to Bcl-2 and preventing the formation of the anti-apoptotic BAX-BCL2 heterodimers.",".",".",".",".","."]
["ENSRNOG00000006999",65,5.396732934,183,11.77247019,0.458419758,-1.125258869,{"v":7.32954e-09,"d":"7.33E-09"},{"v":1.38985E-8,"d":"1.39E-08"},"down","yes","Dnai4","protein_coding","chr5:117788464-117876127:-","gi|67078448|ref|NP_001019957.1|",3842,0,"WD repeat-containing protein 78 [Rattus norvegicus]","gi|67078447|ref|NM_001024786.1|",2315,0,"Rattus norvegicus WD repeat domain 78 (Wdr78), mRNA","Q4V8G4",1476,0,"WD repeat-containing protein 78",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.","GO:0002244|hematopoietic progenitor cell differentiation;GO:0003341|cilium movement;GO:0007018|microtubule-based movement;GO:0070286|axonemal dynein complex assembly;","GO:0005858|axonemal dynein complex;GO:0005930|axoneme;GO:0031514|motile cilium;","GO:0045503|dynein light chain binding;GO:0045504|dynein heavy chain binding;","K24723","DNAI4, WDR78; dynein axonemal intermediate chain 4"]
["ENSRNOG00000031739",61,5.064626292,175,11.25782668,0.449876023,-1.152400618,{"v":8.18492e-09,"d":"8.18E-09"},{"v":1.54746e-08,"d":"1.55E-08"},"down","yes","Fam71e1","protein_coding","chr1:94988613-94993539:+","gi|672013525|ref|XP_008772744.1|",929,{"v":9e-121,"d":"9.00E-121"},"PREDICTED: protein FAM71E1 isoform X3 [Rattus norvegicus]","gi|672013524|ref|XM_008774522.1|",1389,0,"PREDICTED: Rattus norvegicus family with sequence similarity 71, member E1 (Fam71e1), transcript variant X3, mRNA","A1L3C1",290,{"v":3e-94,"d":"3.00E-94"},"Protein FAM71E1",".",".",".",".","pfam12480","DUF3699","Protein of unknown function (DUF3699). This domain family is found in eukaryotes, and is approximately 80 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000028015",45,3.736199724,143,9.19925266,0.406141658,-1.299945084,{"v":1.00577E-8,"d":"1.01E-08"},{"v":1.89147e-08,"d":"1.89E-08"},"down","yes","Pf4","protein_coding","chr14:17298308-17299365:-","gi|56090531|ref|NP_001007730.1|",478,{"v":8e-58,"d":"8.00E-58"},"platelet factor 4 precursor [Rattus norvegicus]","gi|156713446|ref|NM_019932.4|",356,0,"Mus musculus platelet factor 4 (Pf4), mRNA","P06765",188,{"v":3e-59,"d":"3.00E-59"},"Platelet factor 4",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0010628|positive regulation of gene expression;GO:0010744|positive regulation of macrophage derived foam cell differentiation;GO:0016525|negative regulation of angiogenesis;GO:0019221|cytokine-mediated signaling pathway;GO:0030168|platelet activation;GO:0030593|neutrophil chemotaxis;GO:0030595|leukocyte chemotaxis;GO:0031640|killing of cells of other organism;GO:0032760|positive regulation of tumor necrosis factor production;GO:0042127|regulation of cell proliferation;GO:0042832|defense response to protozoan;GO:0045347|negative regulation of MHC class II biosynthetic process;GO:0045651|positive regulation of macrophage differentiation;GO:0045653|negative regulation of megakaryocyte differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051873|killing by host of symbiont cells;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0065003|protein-containing complex assembly;GO:0070098|chemokine-mediated signaling pathway;GO:0071222|cellular response to lipopolysaccharide;GO:2001240|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0031091|platelet alpha granule;GO:0031982|vesicle;GO:0032991|protein-containing complex;","GO:0003674|molecular_function;GO:0008009|chemokine activity;GO:0008201|heparin binding;GO:0045236|CXCR chemokine receptor binding;GO:0048248|CXCR3 chemokine receptor binding;","K05407","PF4, CXCL4; platelet factor 4"]
["ENSRNOG00000009151",72,5.977919558,195,12.54443545,0.476539545,-1.069332156,{"v":1.01418E-8,"d":"1.01E-08"},{"v":1.90617e-08,"d":"1.91E-08"},"down","yes","Mipol1","protein_coding","chr6:74755395-75086811:+","gi|392348833|ref|XP_003750210.1|",1976,0,"PREDICTED: mirror-image polydactyly gene 1 protein isoform X2 [Rattus norvegicus]","gi|672056182|ref|XM_003750162.3|",1871,0,"PREDICTED: Rattus norvegicus mirror-image polydactyly 1 (Mipol1), transcript variant X3, mRNA","Q8TD10",578,0,"Mirror-image polydactyly gene 1 protein",".",".",".",".","pfam05622","HOOK","HOOK protein. This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organisms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas the central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head.",".","GO:0005634|nucleus;","GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000063355",0,0.04151333,34,2.187234898,0.018979823,-5.719389685,{"v":1.09549e-08,"d":"1.10E-08"},{"v":2.05537E-8,"d":"2.06E-08"},"down","yes","ENSRNOG00000063355","miRNA","chr6:103752180-103752264:-",".",".",".",".","gi|755511150|ref|XR_880878.1|",85,{"v":9e-36,"d":"9.00E-36"},"PREDICTED: Mus musculus small ubiquitin-related modifier 2 pseudogene (LOC102636299), transcript variant X2, misc_RNA",".",".",".",".",".",".",".",".","pfam05141","DIT1_PvcA","Pyoverdine/dityrosine biosynthesis protein. DIT1 is involved in synthesising dityrosine. Dityrosine is a sporulation-specific component of the yeast ascospore wall that is essential for the resistance of the spores to adverse environmental conditions. Pyoverdine biosynthesis protein PvcA is involved in the biosynthesis of pyoverdine, a cyclized isocyano derivative of tyrosine. It has a modified Rossmann fold.",".",".",".",".","."]
["ENSRNOG00000003544",7,0.581186624,55,3.5381741,0.164261737,-2.605931635,{"v":1.34153e-08,"d":"1.34E-08"},{"v":2.49794E-8,"d":"2.50E-08"},"down","yes","Tbx4","protein_coding","chr10:70731163-70760825:+","gi|157820223|ref|NP_001100504.1|",2946,0,"T-box transcription factor TBX4 [Rattus norvegicus]","gi|157820222|ref|NM_001107034.1|",3254,0,"Rattus norvegicus T-box 4 (Tbx4), mRNA","P70325",1105,0,"T-box transcription factor TBX4",".",".",".",".","pfam00907","T-box","T-box. The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.","GO:0001525|angiogenesis;GO:0001708|cell fate specification;GO:0002009|morphogenesis of an epithelium;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008150|biological_process;GO:0030324|lung development;GO:0030326|embryonic limb morphogenesis;GO:0035108|limb morphogenesis;GO:0035116|embryonic hindlimb morphogenesis;GO:0048705|skeletal system morphogenesis;GO:1990401|embryonic lung development;","GO:0005575|cellular_component;GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003674|molecular_function;","K10178","TBX4; T-box protein 4"]
["ENSRNOG00000070554",16,1.328426568,79,5.082104617,0.261392999,-1.935707592,{"v":1.34682e-08,"d":"1.35E-08"},{"v":2.50705e-08,"d":"2.51E-08"},"down","yes","ENSRNOG00000070554","lncRNA","chr1:23123683-23127067:-","gi|149028494|gb|EDL83879.1|",225,{"v":8e-20,"d":"8.00E-20"},"rCG22859 [Rattus norvegicus]","gi|27545029|gb|AC091712.3|",734,0,"Rattus norvegicus strain Brown Norway clone RP31-64M17, complete sequence",".",".",".",".",".",".",".",".","pfam02093","Gag_p30","Gag P30 core shell protein. According to Swiss-Prot annotation this protein is the viral core shell protein. P30 is essential for viral assembly.",".",".",".",".","."]
["ENSRNOG00000028460",49,4.068306366,150,9.649565728,0.421605125,-1.24603569,{"v":1.36479E-8,"d":"1.36E-08"},{"v":2.53902e-08,"d":"2.54E-08"},"down","yes","Lrrc8e","protein_coding","chr12:2578315-2589412:+","gi|77627869|ref|NP_001029311.1|",3910,0,"volume-regulated anion channel subunit LRRC8E [Rattus norvegicus]","gi|672071954|ref|XM_006248764.2|",3123,0,"PREDICTED: Rattus norvegicus leucine rich repeat containing 8 family, member E (Lrrc8e), transcript variant X3, mRNA","Q3KRC6",1507,0,"Volume-regulated anion channel subunit LRRC8E","alr0124_1",85.5,{"v":2E-16,"d":"2.00E-16"},"COG4886","pfam12534","DUF3733","Leucine-rich repeat containing protein 8. This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00560. There are two completely conserved residues (W and Y) that may be functionally important. Many of the proteins in this family are annotated as leucine-rich repeat containing protein 8 however there is little accompanying literature to back this up.","GO:0006884|cell volume homeostasis;GO:0015698|inorganic anion transport;GO:0015810|aspartate transmembrane transport;GO:0071470|cellular response to osmotic stress;GO:0098656|anion transmembrane transport;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0030176|integral component of endoplasmic reticulum membrane;GO:0034702|ion channel complex;GO:1905103|integral component of lysosomal membrane;","GO:0005225|volume-sensitive anion channel activity;","K22038","LRRC8; volume-regulated anion channel"]
["ENSRNOG00000018426",31,2.573826476,113,7.269339515,0.35406607,-1.497909496,{"v":1.41865e-08,"d":"1.42E-08"},{"v":2.63615e-08,"d":"2.64E-08"},"down","yes","NEWGENE_2134","protein_coding","chr1:79346136-79350375:-","gi|564401235|ref|XP_003752293.2|",291,{"v":7e-27,"d":"7.00E-27"},"PREDICTED: apolipoprotein C-I-like [Rattus norvegicus]","gi|354798497|gb|JN962998.1|",317,{"v":7e-163,"d":"7.00E-163"},"Mus musculus targeted deletion, lacZ-tagged mutant allele Apoc4:tm1(KOMP)Ucd; transgenic","P19939",86.3,{"v":6e-18,"d":"6.00E-18"},"Apolipoprotein C-I",".",".",".",".","pfam04691","ApoC-I","Apolipoprotein C-I (ApoC-1). Apolipoprotein C-I (ApoC-1) is a water-soluble protein component of plasma lipoprotein. It solubalises lipids and regulates lipid metabolizm. ApoC-1 transfers among HDL (high density lipoprotein), VLDL (very low-density lipoprotein) and chylomicrons. ApoC-1 activates lecithin:choline acetyltransferase (LCAT), inhibits cholesteryl ester transfer protein, can inhibit hepatic lipase and phospholipase 2 and can stimulate cell growth. ApoC-1 delays the clearance of beta-VLDL by inhibiting its uptake via the LDL receptor-related pathway. ApoC-1 has been implicated in hypertriglyceridemia, and Alzheimer's disease.","GO:0006641|triglyceride metabolic process;GO:0006869|lipid transport;GO:0008203|cholesterol metabolic process;GO:0010900|negative regulation of phosphatidylcholine catabolic process;GO:0010916|negative regulation of very-low-density lipoprotein particle clearance;GO:0032368|regulation of lipid transport;GO:0032375|negative regulation of cholesterol transport;GO:0033344|cholesterol efflux;GO:0033700|phospholipid efflux;GO:0034369|plasma lipoprotein particle remodeling;GO:0034382|chylomicron remnant clearance;GO:0034447|very-low-density lipoprotein particle clearance;GO:0042157|lipoprotein metabolic process;GO:0045717|negative regulation of fatty acid biosynthetic process;GO:0045833|negative regulation of lipid metabolic process;GO:0048261|negative regulation of receptor-mediated endocytosis;GO:0050995|negative regulation of lipid catabolic process;GO:0051005|negative regulation of lipoprotein lipase activity;","GO:0005576|extracellular region;GO:0005783|endoplasmic reticulum;GO:0034361|very-low-density lipoprotein particle;GO:0034364|high-density lipoprotein particle;","GO:0003674|molecular_function;GO:0004859|phospholipase inhibitor activity;GO:0005504|fatty acid binding;GO:0055102|lipase inhibitor activity;","K22286","APOC1; apolipoprotein C-I"]
["ENSRNOG00000042717",32,2.656853137,115,7.398000391,0.359131251,-1.477416895,{"v":1.48841E-8,"d":"1.49E-08"},{"v":2.76176e-08,"d":"2.76E-08"},"down","yes","Ciart","protein_coding","chr2:183419819-183423313:-","gi|197385188|ref|NP_001128065.1|",1707,0,"circadian associated repressor of transcription [Rattus norvegicus]","gi|197385187|ref|NM_001134593.1|",1418,0,"Rattus norvegicus circadian associated repressor of transcription (Ciart), mRNA","Q3TQ03",600,0,"Circadian-associated transcriptional repressor",".",".",".",".","pfam15449","Retinal","Retinal protein. This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.","GO:0032922|circadian regulation of gene expression;GO:0045475|locomotor rhythm;GO:0045892|negative regulation of transcription, DNA-templated;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0070888|E-box binding;","K21599","CIART, CHRONO, GM129; circadian-associated transcriptional repressor"]
["ENSRNOG00000003479",69,5.728839576,188,12.09412238,0.473687912,-1.077991239,{"v":1.49945e-08,"d":"1.50E-08"},{"v":2.77902E-8,"d":"2.78E-08"},"down","yes","Rnf150","protein_coding","chr19:25006611-25228678:-","gi|300797709|ref|NP_001178022.1|",2189,0,"RING finger protein 150 precursor [Rattus norvegicus]","gi|672084500|ref|XM_008772417.1|",2427,0,"PREDICTED: Rattus norvegicus ring finger protein 150 (Rnf150), transcript variant X1, mRNA","Q5DTZ6",832,0,"RING finger protein 150",".",".",".",".","pfam13639","zf-RING_2","Ring finger domain.","GO:0006511|ubiquitin-dependent protein catabolic process;GO:0016567|protein ubiquitination;","GO:0005737|cytoplasm;GO:0016021|integral component of membrane;","GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;",".","."]
["ENSRNOG00000029427",17,1.411453229,81,5.210765493,0.270872529,-1.884314005,{"v":1.61527e-08,"d":"1.62E-08"},{"v":2.98073E-8,"d":"2.98E-08"},"down","yes","Grhl3","protein_coding","chr5:147774160-147806160:-","gi|672054381|ref|XP_008762438.1|",3152,0,"PREDICTED: grainyhead-like protein 3 homolog isoform X1 [Rattus norvegicus]","gi|672054380|ref|XM_008764216.1|",2641,0,"PREDICTED: Rattus norvegicus grainyhead-like 3 (Drosophila) (Grhl3), transcript variant X1, mRNA","Q5FWH3",1180,0,"Grainyhead-like protein 3 homolog",".",".",".",".","pfam04516","CP2","CP2 transcription factor. This family represents a conserved region in the CP2 transcription factor family.","GO:0001736|establishment of planar polarity;GO:0001843|neural tube closure;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007389|pattern specification process;GO:0007398|ectoderm development;GO:0007417|central nervous system development;GO:0008544|epidermis development;GO:0010628|positive regulation of gene expression;GO:0032956|regulation of actin cytoskeleton organization;GO:0042060|wound healing;GO:0043547|positive regulation of GTPase activity;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0061029|eyelid development in camera-type eye;GO:0061436|establishment of skin barrier;GO:0090103|cochlea morphogenesis;GO:0090179|planar cell polarity pathway involved in neural tube closure;","GO:0005634|nucleus;GO:0005654|nucleoplasm;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0031490|chromatin DNA binding;GO:0043565|sequence-specific DNA binding;","K09275","TFCP2; transcription factor CP2 and related proteins"]
["ENSRNOG00000054935",35,2.905933118,121,7.78398302,0.37332213,-1.421507064,{"v":1.66787E-8,"d":"1.67E-08"},{"v":3.07335e-08,"d":"3.07E-08"},"down","yes","AC119007.4","lncRNA","chr7:132408978-132413672:+","gi|149031988|gb|EDL86900.1|",392,{"v":2E-41,"d":"2.00E-41"},"rCG50756, partial [Rattus norvegicus]","gi|672022400|ref|XR_602000.1|",1987,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103692985 (LOC103692985), ncRNA",".",".",".",".",".",".",".",".","pfam15091","DUF4554","Domain of unknown function (DUF4554). This family of proteins is functionally uncharacterized. This family of proteins is found in some vertebrates. This family includes human protein C11orf80.",".",".",".",".","."]
["ENSRNOG00000018748",47,3.902253045,145,9.327913537,0.418341468,-1.257247082,{"v":1.89183e-08,"d":"1.89E-08"},{"v":3.47304e-08,"d":"3.47E-08"},"down","yes","Slc16a11","protein_coding","chr10:54927725-54942915:+","gi|53850584|ref|NP_001005530.1|",1164,{"v":8e-139,"d":"8.00E-139"},"monocarboxylate transporter 13 [Rattus norvegicus]","gi|354794370|gb|JN958871.1|",1737,0,"Mus musculus targeted deletion, lacZ-tagged mutant allele Slc16a11:tm1(KOMP)Ucd; transgenic","Q66HE2",452,{"v":3e-140,"d":"3.00E-140"},"Monocarboxylate transporter 13","AF0367",63.5,5e-09,"COG0477","pfam07690","MFS_1","Major Facilitator Superfamily.","GO:0006629|lipid metabolic process;GO:0015718|monocarboxylic acid transport;GO:1901475|pyruvate transmembrane transport;","GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;","GO:0008028|monocarboxylic acid transmembrane transporter activity;GO:0050833|pyruvate transmembrane transporter activity;","K08188","SLC16A11; MFS transporter, MCT family, solute carrier family 16 (monocarboxylic acid transporters), member 11"]
["ENSRNOG00000040201",43,3.570146403,137,8.813270031,0.4050876,-1.303694172,{"v":1.90096e-08,"d":"1.90E-08"},{"v":3.48679E-8,"d":"3.49E-08"},"down","yes","Atp6ap1l","protein_coding","chr2:22037563-22065038:-","gi|300797587|ref|NP_001178772.1|",1440,0,"V-type proton ATPase subunit S1-like protein precursor [Rattus norvegicus]","gi|300797586|ref|NM_001191843.1|",1132,0,"Rattus norvegicus ATPase H+ transporting accessory protein 1 like (Atp6ap1l), mRNA","Q52LC2",224,{"v":2e-69,"d":"2.00E-69"},"V-type proton ATPase subunit S1-like protein",".",".",".",".","pfam01299","Lamp","Lysosome-associated membrane glycoprotein (Lamp).","GO:0030641|regulation of cellular pH;GO:1902600|proton transmembrane transport;","GO:0016021|integral component of membrane;GO:0033180|proton-transporting V-type ATPase, V1 domain;GO:0033181|plasma membrane proton-transporting V-type ATPase complex;",".",".","."]
["ENSRNOG00000031612",76,6.3100262,200,12.86608764,0.490438615,-1.02785552,{"v":1.9484e-08,"d":"1.95E-08"},{"v":3.56971e-08,"d":"3.57E-08"},"down","yes","Gls2","protein_coding","chr7:617288-633426:+","gi|951613627|gb|ALN69381.1|",2518,0,"glutaminase variant 6 [Rattus norvegicus]","gi|672057463|ref|XM_006240730.2|",1888,0,"PREDICTED: Rattus norvegicus glutaminase 2 (liver, mitochondrial) (Gls2), transcript variant X2, mRNA","P28492",973,0,"Glutaminase liver isoform, mitochondrial","all2934",248,{"v":2e-72,"d":"2.00E-72"},"COG2066","pfam04960","Glutaminase","Glutaminase. This family of enzymes deaminates glutamine to glutamate EC:3.5.1.2.","GO:0006537|glutamate biosynthetic process;GO:0006541|glutamine metabolic process;GO:0006543|glutamine catabolic process;GO:0042981|regulation of apoptotic process;GO:0072593|reactive oxygen species metabolic process;","GO:0005739|mitochondrion;GO:0005759|mitochondrial matrix;","GO:0004359|glutaminase activity;","K01425","glsA, GLS; glutaminase [EC:3.5.1.2]"]
["ENSRNOG00000007256",12,0.996319926,68,4.374469797,0.227757871,-2.134427184,{"v":1.97637e-08,"d":"1.98E-08"},{"v":3.61992e-08,"d":"3.62E-08"},"down","yes","Necab1","protein_coding","chr5:28330206-28357152:+","gi|755505878|ref|XP_011248190.1|",624,{"v":7e-73,"d":"7.00E-73"},"PREDICTED: uncharacterized protein C8orf88 homolog isoform X2 [Mus musculus]","gi|295054745|gb|AC109757.5|",1873,0,"Rattus norvegicus BAC CH230-218I7 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P0DMB2",209,{"v":7e-62,"d":"7.00E-62"},"Uncharacterized protein C8orf88",".",".",".",".","pfam03585","Herpes_ICP4_C","Herpesvirus ICP4-like protein C-terminal region. The immediate-early protein ICP4 (infected-cell polypeptide 4) is required for efficient transcription of early and late viral genes and is thus essential for productive infection. ICP4 is a large phosphoprotein that binds DNA in a sequence specific manner as a homodimer. ICP4 represses transcription from LAT, ICP4 and ORF-P that have high-affinity a ICP4 binding site that spans the transcription initiation site. ICP4 proteins have two highly conserved regions, this family contains the C-terminal region that probably acts as an enhancer for the N-terminal region.","GO:0001835|blastocyst hatching;GO:0042984|regulation of amyloid precursor protein biosynthetic process;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0005509|calcium ion binding;GO:0042802|identical protein binding;","K23854","NECAB; N-terminal EF-hand calcium-binding protein"]
["ENSRNOG00000022738",60,4.981599631,170,10.93617449,0.455515741,-1.134427184,{"v":2.01755e-08,"d":"2.02E-08"},{"v":3.69111e-08,"d":"3.69E-08"},"down","yes","AC098459.1","protein_coding","chr6:75727440-75728627:-","gi|564328458|ref|XP_006229294.1|",1580,0,"PREDICTED: L-lactate dehydrogenase A chain isoform X1 [Rattus norvegicus]","gi|197245746|gb|BC168737.1|",722,0,"Rattus norvegicus lactate dehydrogenase A, mRNA (cDNA clone MGC:188833 IMAGE:6917937), complete cds","P04642",597,0,"L-lactate dehydrogenase A chain","CAC0267",236,{"v":5E-74,"d":"5.00E-74"},"COG0039","pfam00056","Ldh_1_N","lactate/malate dehydrogenase, NAD binding domain. L-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate. The enzyme participates in the citric acid cycle. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes. N-terminus (this family) is a Rossmann NAD-binding fold. C-terminus is an unusual alpha+beta fold.",".",".",".",".","."]
["ENSRNOG00000027463",18,1.494479889,82,5.275095931,0.283308571,-1.819553847,{"v":2.85323E-8,"d":"2.85E-08"},{"v":5.158e-08,"d":"5.16E-08"},"down","yes","Adamts3","protein_coding","chr14:18231165-18435556:+","gi|564383161|ref|XP_006250836.1|",6271,0,"PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 3 isoform X2 [Rattus norvegicus]","gi|672075767|ref|XM_006250773.2|",4293,0,"PREDICTED: Rattus norvegicus ADAM metallopeptidase with thrombospondin type 1, motif 3 (Adamts3), transcript variant X1, mRNA","O15072",2133,0,"A disintegrin and metalloproteinase with thrombospondin motifs 3",".",".",".",".","pfam01562","Pep_M12B_propep","Reprolysin family propeptide. This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the \"cysteine switch\" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.","GO:0001701|in utero embryonic development;GO:0007229|integrin-mediated signaling pathway;GO:0010573|vascular endothelial growth factor production;GO:0016485|protein processing;GO:0030198|extracellular matrix organization;GO:0032964|collagen biosynthetic process;GO:1900748|positive regulation of vascular endothelial growth factor signaling pathway;","GO:0005615|extracellular space;GO:0031012|extracellular matrix;","GO:0004175|endopeptidase activity;GO:0004222|metalloendopeptidase activity;GO:0008233|peptidase activity;GO:0046872|metal ion binding;","K08619","ADAMTS3; a disintegrin and metalloproteinase with thrombospondin motifs 3 [EC:3.4.24.-]"]
["ENSRNOG00000001704",66,5.479759595,180,11.57947887,0.473230242,-1.079385821,{"v":2.92809E-8,"d":"2.93E-08"},{"v":5.28437e-08,"d":"5.28E-08"},"down","yes","Runx1","protein_coding","chr11:31843764-32074542:-","gi|8392900|ref|NP_059021.1|",2098,0,"runt-related transcription factor 1 [Rattus norvegicus]","gi|830260147|ref|NM_017325.2|",2135,0,"Rattus norvegicus runt-related transcription factor 1 (Runx1), mRNA","Q63046",812,0,"Runt-related transcription factor 1",".",".",".",".","pfam00853","Runt","Runt domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001501|skeletal system development;GO:0001503|ossification;GO:0001701|in utero embryonic development;GO:0001889|liver development;GO:0002062|chondrocyte differentiation;GO:0002318|myeloid progenitor cell differentiation;GO:0002573|myeloid leukocyte differentiation;GO:0002667|regulation of T cell anergy;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007417|central nervous system development;GO:0008285|negative regulation of cell proliferation;GO:0009966|regulation of signal transduction;GO:0014894|response to denervation involved in regulation of muscle adaptation;GO:0030097|hemopoiesis;GO:0030099|myeloid cell differentiation;GO:0030182|neuron differentiation;GO:0030728|ovulation;GO:0030853|negative regulation of granulocyte differentiation;GO:0030854|positive regulation of granulocyte differentiation;GO:0031069|hair follicle morphogenesis;GO:0032526|response to retinoic acid;GO:0032729|positive regulation of interferon-gamma production;GO:0032743|positive regulation of interleukin-2 production;GO:0035162|embryonic hemopoiesis;GO:0043371|negative regulation of CD4-positive, alpha-beta T cell differentiation;GO:0043378|positive regulation of CD8-positive, alpha-beta T cell differentiation;GO:0045595|regulation of cell differentiation;GO:0045766|positive regulation of angiogenesis;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048266|behavioral response to pain;GO:0048663|neuron fate commitment;GO:0048666|neuron development;GO:0060216|definitive hemopoiesis;GO:0071336|regulation of hair follicle cell proliferation;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:1903431|positive regulation of cell maturation;GO:2000872|positive regulation of progesterone secretion;","GO:0000785|chromatin;GO:0005604|basement membrane;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0016513|core-binding factor complex;GO:0043231|intracellular membrane-bounded organelle;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0005509|calcium ion binding;GO:0005524|ATP binding;GO:0042803|protein homodimerization activity;GO:0046982|protein heterodimerization activity;GO:1990837|sequence-specific double-stranded DNA binding;GO:1990841|promoter-specific chromatin binding;","K08367","RUNX1, AML1; runt-related transcription factor 1"]
["ENSRNOG00000003899",57,4.73251965,163,10.48586142,0.451323879,-1.147764984,{"v":2.93075E-8,"d":"2.93E-08"},{"v":5.28699e-08,"d":"5.29E-08"},"down","yes","Krt15","protein_coding","chr10:85066802-85171799:-","gi|56912233|ref|NP_001008751.1|",2017,0,"keratin, type I cytoskeletal 14 [Rattus norvegicus]","gi|56912232|ref|NM_001008751.1|",1458,0,"Rattus norvegicus keratin 14, type I (Krt14), mRNA","Q6IFV1",781,0,"Keratin, type I cytoskeletal 14",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0007568|aging;GO:0010043|response to zinc ion;GO:0010212|response to ionizing radiation;GO:0030855|epithelial cell differentiation;GO:0042633|hair cycle;GO:0045110|intermediate filament bundle assembly;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005882|intermediate filament;GO:0045095|keratin filament;GO:0045178|basal part of cell;GO:0071944|cell periphery;","GO:0003674|molecular_function;GO:0005198|structural molecule activity;GO:1990254|keratin filament binding;","K07604","KRT1; type I keratin, acidic"]
["ENSRNOG00000033531",9,0.747239945,59,3.795495853,0.196875448,-2.344644892,{"v":3.04377e-08,"d":"3.04E-08"},{"v":5.4823e-08,"d":"5.48E-08"},"down","yes","Cacna2d1","protein_coding","chr4:18951002-19374969:-","gi|31542335|ref|NP_037051.2|",5405,0,"voltage-dependent calcium channel subunit alpha-2/delta-1 isoform 1 precursor [Rattus norvegicus]","gi|402744513|ref|NM_012919.3|",3242,0,"Rattus norvegicus calcium voltage-gated channel auxiliary subunit alpha2delta 1 (Cacna2d1), transcript variant 1, mRNA","O08532",2055,0,"Voltage-dependent calcium channel subunit alpha-2/delta-1",".",".",".",".","pfam08399","VWA_N","VWA N-terminal. This domain is found at the N-terminus of proteins containing von Willebrand factor type A (VWA, pfam00092) and Cache (pfam02743) domains. It has been found in vertebrates, Drosophila and C. elegans but has not yet been identified in other eukaryotes. It is probably involved in the function of some voltage-dependent calcium channel subunits.","GO:0006816|calcium ion transport;GO:0034765|regulation of ion transmembrane transport;GO:0051924|regulation of calcium ion transport;GO:0060307|regulation of ventricular cardiac muscle cell membrane repolarization;GO:0060402|calcium ion transport into cytosol;GO:0061577|calcium ion transmembrane transport via high voltage-gated calcium channel;GO:0070588|calcium ion transmembrane transport;GO:0086002|cardiac muscle cell action potential involved in contraction;GO:0086048|membrane depolarization during bundle of His cell action potential;GO:0086091|regulation of heart rate by cardiac conduction;GO:0098903|regulation of membrane repolarization during action potential;GO:1901387|positive regulation of voltage-gated calcium channel activity;GO:1901843|positive regulation of high voltage-gated calcium channel activity;GO:1902514|regulation of calcium ion transmembrane transport via high voltage-gated calcium channel;GO:1904646|cellular response to amyloid-beta;","GO:0005891|voltage-gated calcium channel complex;GO:0016021|integral component of membrane;GO:0016529|sarcoplasmic reticulum;GO:0030315|T-tubule;GO:0098978|glutamatergic synapse;GO:0099025|anchored component of postsynaptic membrane;GO:0099029|anchored component of presynaptic active zone membrane;GO:1990454|L-type voltage-gated calcium channel complex;","GO:0005244|voltage-gated ion channel activity;GO:0005245|voltage-gated calcium channel activity;GO:0005262|calcium channel activity;GO:0005515|protein binding;GO:0046872|metal ion binding;GO:0086057|voltage-gated calcium channel activity involved in bundle of His cell action potential;","K04858","CACNA2D1; voltage-dependent calcium channel alpha-2/delta-1"]
["ENSRNOG00000054385",27,2.241719834,102,6.561704695,0.341636806,-1.549464684,{"v":3.31552e-08,"d":"3.32E-08"},{"v":5.955e-08,"d":"5.96E-08"},"down","yes","Rhebl1","protein_coding","chr7:130026341-130030248:-","gi|33414521|ref|NP_877977.1|",978,{"v":1e-129,"d":"1.00E-129"},"GTPase RhebL1 precursor [Rattus norvegicus]","gi|33414520|ref|NM_182825.1|",1182,0,"Rattus norvegicus Ras homolog enriched in brain like 1 (Rhebl1), mRNA","Q7TNZ5",381,{"v":4e-131,"d":"4.00E-131"},"GTPase RhebL1",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0007264|small GTPase mediated signal transduction;GO:0031929|TOR signaling;GO:0051092|positive regulation of NF-kappaB transcription factor activity;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0012505|endomembrane system;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0019003|GDP binding;GO:0046872|metal ion binding;","K07849","RHEBL1; Ras homolog enriched in brain like 1"]
["ENSRNOG00000068121",11,0.913293266,64,4.117148044,0.221826676,-2.172495225,{"v":3.64742e-08,"d":"3.65E-08"},{"v":6.52912e-08,"d":"6.53E-08"},"down","yes","ENSRNOG00000068121","lncRNA","chr18:30489217-30568888:+","gi|672083161|ref|XP_008770290.1|",574,{"v":1e-63,"d":"1.00E-63"},"PREDICTED: rho GTPase-activating protein 26 isoform X1 [Rattus norvegicus]","gi|672083160|ref|XM_008772068.1|",442,0,"PREDICTED: Rattus norvegicus Rho GTPase activating protein 26 (Arhgap26), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam06248","Zw10","Centromere/kinetochore Zw10. Zw10 and rough deal proteins are both required for correct metaphase check-pointing during mitosis. These proteins bind to the centromere/kinetochore.",".",".",".",".","."]
["ENSRNOG00000063519",15,1.245399908,74,4.760452426,0.26161377,-1.934489614,{"v":3.90642e-08,"d":"3.91E-08"},{"v":6.96349e-08,"d":"6.96E-08"},"down","yes","ENSRNOG00000063519","lncRNA","chr13:45843939-45846361:-","gi|148701441|gb|EDL33388.1|",198,{"v":1e-16,"d":"1.00E-16"},"mCG1045525, partial [Mus musculus]","gi|672074167|ref|XR_595471.1|",219,{"v":3e-109,"d":"3.00E-109"},"PREDICTED: Rattus norvegicus uncharacterized LOC102552665 (LOC102552665), ncRNA",".",".",".",".",".",".",".",".","pfam09961","DUF2195","Uncharacterized protein conserved in bacteria (DUF2195). This domain, found in various hypothetical bacterial proteins, has no known function.",".",".",".",".","."]
["ENSRNOG00000003881",48,3.985279705,144,9.263583099,0.430209311,-1.216889345,{"v":4.75017e-08,"d":"4.75E-08"},{"v":8.40429e-08,"d":"8.40E-08"},"down","yes","Nit1","protein_coding","chr13:83765941-83773332:-","gi|128485833|ref|NP_872609.2|",1605,0,"nitrilase homolog 1 isoform a [Rattus norvegicus]","gi|128485843|ref|NM_001082580.1|",1256,0,"Rattus norvegicus nitrilase 1 (Nit1), transcript variant 2, mRNA","Q7TQ94",622,0,"Deaminated glutathione amidase","SPBC651.02",228,{"v":2e-68,"d":"2.00E-68"},"COG0388","pfam00795","CN_hydrolase","Carbon-nitrogen hydrolase. This family contains hydrolases that break carbon-nitrogen bonds. The family includes: Nitrilase EC:3.5.5.1, Aliphatic amidase EC:3.5.1.4, Biotidinase EC:3.5.1.12, Beta-ureidopropionase EC:3.5.1.6. Nitrilase-related proteins generally have a conserved E-K-C catalytic triad, and are multimeric alpha-beta-beta-alpha sandwich proteins.","GO:0043605|cellular amide catabolic process;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;","GO:0110050|deaminated glutathione amidase activity;","K11206","NIT1, ybeM; deaminated glutathione amidase [EC:3.5.1.128]"]
["ENSRNOG00000013866",55,4.566466329,157,10.0998788,0.452130805,-1.145187879,{"v":5.55055E-8,"d":"5.55E-08"},{"v":9.75826e-08,"d":"9.76E-08"},"down","yes","Usp49","protein_coding","chr9:13308178-13366132:-","gi|210147497|ref|NP_001129942.1|",3479,0,"ubiquitin carboxyl-terminal hydrolase 49 [Rattus norvegicus]","gi|210147496|ref|NM_001136470.1|",5363,0,"Rattus norvegicus ubiquitin specific peptidase 49 (Usp49), mRNA","Q6P9L4",1299,0,"Ubiquitin carboxyl-terminal hydrolase 49",".",".",".",".","pfam00443","UCH","Ubiquitin carboxyl-terminal hydrolase.","GO:0000398|mRNA splicing, via spliceosome;GO:0006511|ubiquitin-dependent protein catabolic process;GO:0016579|protein deubiquitination;GO:0035616|histone H2B conserved C-terminal lysine deubiquitination;","GO:0005737|cytoplasm;","GO:0004197|cysteine-type endopeptidase activity;GO:0004843|thiol-dependent ubiquitin-specific protease activity;GO:0008270|zinc ion binding;GO:0042393|histone binding;","K11834","USP44_49; ubiquitin carboxyl-terminal hydrolase 44/49 [EC:3.4.19.12]"]
["ENSRNOG00000016672",5,0.415133303,46,2.959200157,0.140285645,-2.833560705,{"v":5.62067e-08,"d":"5.62E-08"},{"v":9.87339e-08,"d":"9.87E-08"},"down","yes","Fam217a","protein_coding","chr17:29966651-29981455:+","gi|568982056|ref|XP_006516846.1|",2586,0,"PREDICTED: protein FAM217A isoform X2 [Mus musculus]","gi|402747040|ref|NM_001271083.1|",1876,0,"Rattus norvegicus family with sequence similarity 217, member A (Fam217a), mRNA",".",".",".",".",".",".",".",".","pfam15344","FAM217","FAM217 family. This family of proteins is found in eukaryotes. Proteins in this family are typically between 329 and 507 amino acids in length. There is a conserved YPDFLP sequence motif.",".",".",".",".","."]
["ENSRNOG00000007118",39,3.23803976,125,8.041304773,0.402675915,-1.31230891,{"v":6.79951E-8,"d":"6.80E-08"},{"v":1.18465E-7,"d":"1.18E-07"},"down","yes","Eva1a","protein_coding","chr4:114593341-114643011:+","gi|672050069|ref|XP_008761249.1|",683,{"v":2e-82,"d":"2.00E-82"},"PREDICTED: protein eva-1 homolog A isoform X2 [Rattus norvegicus]","gi|157823488|ref|NM_001109243.1|",1741,0,"Rattus norvegicus eva-1 homolog A, regulator of programmed cell death (Eva1a), mRNA","Q91WM6",204,{"v":1e-60,"d":"1.00E-60"},"Protein eva-1 homolog A",".",".",".",".","pfam14851","FAM176","FAM176 family. Members of the FAM176 family regulate autophagy and apoptosis.","GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0003674|molecular_function;",".","."]
["ENSRNOG00000015783",41,3.404093082,129,8.298626526,0.410199576,-1.285602095,{"v":6.83713E-8,"d":"6.84E-08"},{"v":1.19088E-7,"d":"1.19E-07"},"down","yes","Abca16","protein_coding","chr1:174795082-174974937:+","gi|564298271|ref|XP_006223538.1|",8394,0,"PREDICTED: ATP-binding cassette sub-family A member 3-like isoform X1 [Rattus norvegicus]","gi|672014204|ref|XM_006223476.2|",5348,0,"PREDICTED: Rattus norvegicus ATP-binding cassette, subfamily A (ABC1), member 16 (Abca16), transcript variant X1, mRNA","Q99758",1417,0,"ATP-binding cassette sub-family A member 3","MA0868",157,{"v":4E-41,"d":"4.00E-41"},"COG1131","pfam00005","ABC_tran","ABC transporter. ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide or belong in different polypeptide chains.","GO:0006869|lipid transport;GO:0055085|transmembrane transport;","GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0005319|lipid transporter activity;GO:0005524|ATP binding;GO:0042626|ATPase activity, coupled to transmembrane movement of substances;","K05643","ABCA3; ATP-binding cassette, subfamily A (ABC1), member 3"]
["ENSRNOG00000063551",0,0.04151333,30,1.929913146,0.021510466,-5.538817439,{"v":8.12674e-08,"d":"8.13E-08"},{"v":1.40365E-7,"d":"1.40E-07"},"down","yes","ENSRNOG00000063551","lncRNA","chr5:70168476-70171183:+","gi|37361874|gb|AAQ91050.1|",125,{"v":2e-11,"d":"2.00E-11"},"LRRGT00094 [Rattus norvegicus]","gi|49457876|gb|AC129700.8|",1588,0,"Rattus norvegicus 4 BAC CH230-10L17 (Children's Hospital Oakland Research Institute) complete sequence","P51517",53.9,7e-06,"Gag-Pro-Pol polyprotein",".",".",".",".","pfam14828","Amnionless","Amnionless. The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.",".",".",".",".","."]
["ENSRNOG00000013698",4,0.332106642,42,2.701878404,0.122916946,-3.024244267,{"v":8.40669e-08,"d":"8.41E-08"},{"v":1.44888e-07,"d":"1.45E-07"},"down","yes","ENSRNOG00000013698","protein_coding","chrX:114965767-115005278:+","gi|564323265|ref|XP_006227579.1|",2198,0,"PREDICTED: testin [Rattus norvegicus]","gi|672032704|ref|XM_006227517.2|",1453,0,"PREDICTED: Rattus norvegicus similar to hypothetical protein (RGD1566387), transcript variant X1, mRNA","Q2LAP6",668,0,"Testin",".",".",".",".","pfam06297","PET","PET Domain. This domain is suggested to be involved in protein-protein interactions. The family is found in conjunction with pfam00412.","GO:0042127|regulation of cell proliferation;","GO:0005737|cytoplasm;GO:0005925|focal adhesion;","GO:0008270|zinc ion binding;",".","."]
["ENSRNOG00000016760",67,5.562786255,178,11.450818,0.485798155,-1.041571084,{"v":8.48164e-08,"d":"8.48E-08"},{"v":1.4614e-07,"d":"1.46E-07"},"down","yes","Kctd19","protein_coding","chr19:33259970-33292006:-","gi|762006002|ref|NP_001292128.1|",4825,0,"potassium channel tetramerization domain containing 19 [Rattus norvegicus]","gi|672031234|ref|XM_008774227.1|",2893,0,"PREDICTED: Rattus norvegicus potassium channel tetramerization domain containing 19 (Kctd19), transcript variant X2, mRNA","Q562E2",1774,0,"BTB/POZ domain-containing protein KCTD19",".",".",".",".","pfam02214","BTB_2","BTB/POZ domain. In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.","GO:0051260|protein homooligomerization;",".",".",".","."]
["ENSRNOG00000021269",8,0.664213284,54,3.473843662,0.191204138,-2.386814346,{"v":8.55395e-08,"d":"8.55E-08"},{"v":1.47267e-07,"d":"1.47E-07"},"down","yes","Chgb","protein_coding","chr3:120043738-120057166:+","gi|564343142|ref|XP_006235134.1|",2695,0,"PREDICTED: secretogranin-1 isoform X1 [Rattus norvegicus]","gi|672046753|ref|XM_006235072.2|",2226,0,"PREDICTED: Rattus norvegicus chromogranin B (secretogranin 1) (Chgb), transcript variant X1, mRNA","O35314",1040,0,"Secretogranin-1",".",".",".",".","pfam01271","Granin","Granin (chromogranin or secretogranin).",".","GO:0005615|extracellular space;GO:0030141|secretory granule;",".","K19991","CHGB; chromogranin-B"]
["ENSRNOG00000066520",2,0.166053321,35,2.251565336,0.073750168,-3.761209861,{"v":8.60525e-08,"d":"8.61E-08"},{"v":1.4807E-7,"d":"1.48E-07"},"down","yes","ENSRNOG00000066520","protein_coding","chr9:20660322-20662313:-","gi|672023860|ref|XP_008756222.1|",225,{"v":8e-22,"d":"8.00E-22"},"PREDICTED: polyubiquitin 8-like isoform X1 [Rattus norvegicus]","gi|672064669|ref|XM_008766948.1|",123,{"v":2e-56,"d":"2.00E-56"},"PREDICTED: Rattus norvegicus polyubiquitin 12-like (LOC102557398), transcript variant X2, partial mRNA",".",".",".",".",".",".",".",".","pfam02141","DENN","DENN (AEX-3) domain. DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.",".",".",".",".","."]
["ENSRNOG00000033923",34,2.822906458,114,7.333669953,0.384924121,-1.377354017,{"v":8.87889e-08,"d":"8.88E-08"},{"v":1.52328e-07,"d":"1.52E-07"},"down","yes","Aox2","protein_coding","chr9:59828084-59916146:+","gi|672065175|ref|XP_008765328.1|",6863,0,"PREDICTED: aldehyde oxidase 2 isoform X1 [Rattus norvegicus]","gi|672065174|ref|XM_008767106.1|",4403,0,"PREDICTED: Rattus norvegicus aldehyde oxidase 2 (Aox2), transcript variant X1, mRNA","Q5QE78",2608,0,"Aldehyde oxidase 2","SMb21287",476,{"v":3e-147,"d":"3.00E-147"},"COG4631","pfam02738","Ald_Xan_dh_C2","Molybdopterin-binding domain of aldehyde dehydrogenase.","GO:0006805|xenobiotic metabolic process;","GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004031|aldehyde oxidase activity;GO:0005506|iron ion binding;GO:0016491|oxidoreductase activity;GO:0042803|protein homodimerization activity;GO:0043546|molybdopterin cofactor binding;GO:0050250|retinal oxidase activity;GO:0050660|flavin adenine dinucleotide binding;GO:0051287|NAD binding;GO:0051537|2 iron, 2 sulfur cluster binding;GO:0071949|FAD binding;GO:0102797|geranial:oxygen oxidoreductase activity;GO:0102798|heptaldehyde:oxygen oxidoreductase activity;","K00157","AOX; aldehyde oxidase [EC:1.2.3.1]"]
["ENSRNOG00000066624",35,2.905933118,116,7.462330829,0.389413601,-1.360624822,{"v":9.04436e-08,"d":"9.04E-08"},{"v":1.55042e-07,"d":"1.55E-07"},"down","yes","ENSRNOG00000066624","lncRNA","chr14:94563775-94574801:-",".",".",".",".","gi|672028179|ref|XR_340440.2|",2547,0,"PREDICTED: Rattus norvegicus uncharacterized LOC100911950 (LOC100911950), ncRNA",".",".",".",".",".",".",".",".","pfam10977","DUF2797","Protein of unknown function (DUF2797). This family of proteins has no known function.",".",".",".",".","."]
["ENSRNOG00000068201",70,5.811866237,183,11.77247019,0.493682816,-1.018343665,{"v":9.7362e-08,"d":"9.74E-08"},{"v":1.66144e-07,"d":"1.66E-07"},"down","yes","ENSRNOG00000068201","protein_coding","chrX:17118816-17129381:-","gi|564322560|ref|XP_006227357.1|",1615,0,"PREDICTED: spindlin-2B-like isoform X1 [Rattus norvegicus]","gi|672032098|ref|XM_006227295.2|",1909,0,"PREDICTED: Rattus norvegicus similar to Spindlin-like protein 2 (SPIN-2) (RGD1565862), transcript variant X1, mRNA","Q5RA80",311,{"v":5e-98,"d":"5.00E-98"},"Spindlin-2",".",".",".",".","pfam02513","Spin-Ssty","Spin/Ssty Family. Spindlin (Spin) is a novel maternal transcript present in the unfertilised egg and early embryo. The Y-linked spermiogenesis -specific transcript (Ssty) is also expressed during gametogenesis and forms part of this Pfam family. Members of this family contain three copies of this 50 residue repeat. The repeat is predicted to contain four beta strands.",".",".",".",".","."]
["ENSRNOG00000003765",67,5.562786255,177,11.38648756,0.488542777,-1.033443203,{"v":1.11267E-7,"d":"1.11E-07"},{"v":1.88564e-07,"d":"1.89E-07"},"down","yes","Nr0b1","protein_coding","chrX:50756886-50761011:+","gi|149042339|gb|EDL96046.1|",2515,0,"nuclear receptor subfamily 0, group B, member 1 [Rattus norvegicus]","gi|16758011|ref|NM_053317.1|",1725,0,"Rattus norvegicus nuclear receptor subfamily 0, group B, member 1 (Nr0b1), mRNA","P70503",953,0,"Nuclear receptor subfamily 0 group B member 1",".",".",".",".","pfam14046","NR_Repeat","Nuclear receptor repeat. This is a repeat domain involved in dimerization of nuclear receptors proteins and in transcriptional regulation in general. It contains a Leu-Xaa-Xaa-Leu-Leu motif which has been characterized for the orphan nuclear receptor Dax-1, which represses the constitutively expressed protein Ad4BP/SF-1. The LXXLL motif plays in important role in binding of Dax-1 to Ad4BP/SF-1. The domain is subject to structure determination by the Joint Center of Structural Genomics.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0007283|spermatogenesis;GO:0007530|sex determination;GO:0008104|protein localization;GO:0008406|gonad development;GO:0008584|male gonad development;GO:0010033|response to organic substance;GO:0010894|negative regulation of steroid biosynthetic process;GO:0030154|cell differentiation;GO:0030238|male sex determination;GO:0030325|adrenal gland development;GO:0033144|negative regulation of intracellular steroid hormone receptor signaling pathway;GO:0033327|Leydig cell differentiation;GO:0035902|response to immobilization stress;GO:0043433|negative regulation of DNA-binding transcription factor activity;GO:0043434|response to peptide hormone;GO:0045892|negative regulation of transcription, DNA-templated;GO:0050810|regulation of steroid biosynthetic process;GO:0060008|Sertoli cell differentiation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0016020|membrane;GO:0016607|nuclear speck;GO:0034451|centriolar satellite;GO:0042788|polysomal ribosome;GO:0043231|intracellular membrane-bounded organelle;","GO:0003677|DNA binding;GO:0003690|double-stranded DNA binding;GO:0003714|transcription corepressor activity;GO:0003723|RNA binding;GO:0008134|transcription factor binding;GO:0016922|nuclear receptor binding;GO:0019904|protein domain specific binding;GO:0032448|DNA hairpin binding;GO:0042803|protein homodimerization activity;GO:0043565|sequence-specific DNA binding;GO:0050682|AF-2 domain binding;","K08562","NR0B1, DAX1; nuclear receptor subfamily 0 group B member 1"]
["ENSRNOG00000011566",67,5.562786255,177,11.38648756,0.488542777,-1.033443203,{"v":1.11267E-7,"d":"1.11E-07"},{"v":1.88564e-07,"d":"1.89E-07"},"down","yes","Cecr2","protein_coding","chr4:153890206-153993451:+","gi|672050898|ref|XP_008761473.1|",6383,0,"PREDICTED: cat eye syndrome critical region protein 2 isoform X1 [Rattus norvegicus]","gi|672050897|ref|XM_008763251.1|",4838,0,"PREDICTED: Rattus norvegicus cat eye syndrome chromosome region, candidate 2 (Cecr2), transcript variant X1, mRNA","E9Q2Z1",2276,0,"Cat eye syndrome critical region protein 2 homolog","YGR252w",89,{"v":2e-17,"d":"2.00E-17"},"COG5076","pfam00439","Bromodomain","Bromodomain. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.","GO:0001842|neural fold formation;GO:0001843|neural tube closure;GO:0006338|chromatin remodeling;GO:0007338|single fertilization;GO:0021915|neural tube development;GO:0060122|inner ear receptor cell stereocilium organization;GO:0090102|cochlea development;GO:0097194|execution phase of apoptosis;","GO:0000791|euchromatin;GO:0005634|nucleus;GO:0031010|ISWI-type complex;GO:0090537|CERF complex;",".",".","."]
["ENSRNOG00000006236",34,2.822906458,113,7.269339515,0.388330529,-1.364642965,{"v":1.24152e-07,"d":"1.24E-07"},{"v":2.08906E-7,"d":"2.09E-07"},"down","yes","Dsn1","protein_coding","chr3:145652737-145665856:-","gi|564343903|ref|XP_006235437.1|",1670,0,"PREDICTED: kinetochore-associated protein DSN1 homolog isoform X2 [Rattus norvegicus]","gi|672047617|ref|XM_006235375.2|",2066,0,"PREDICTED: Rattus norvegicus DSN1, MIS12 kinetochore complex component (Dsn1), transcript variant X1, mRNA","Q9CYC5",584,0,"Kinetochore-associated protein DSN1 homolog","SPCC576.08c",141,{"v":8e-36,"d":"8.00E-36"},"COG0098","pfam08202","MIS13","Mis12-Mtw1 protein family. Mis12-Mtw1 is a eukaryotic conserved kinetochore protein that is involved in chromosome segregation.","GO:0000070|mitotic sister chromatid segregation;GO:0051301|cell division;","GO:0000444|MIS12/MIND type complex;GO:0000776|kinetochore;GO:0000818|nuclear MIS12/MIND complex;GO:0001650|fibrillar center;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005829|cytosol;GO:0016604|nuclear body;",".","K11544","DSN1; kinetochore-associated protein DSN1"]
["ENSRNOG00000065214",39,3.23803976,123,7.912643897,0.409223491,-1.28903913,{"v":1.29629E-7,"d":"1.30E-07"},{"v":2.17548e-07,"d":"2.18E-07"},"down","yes","ENSRNOG00000065214","protein_coding","chr1:117222298-117223587:+","gi|149055516|gb|EDM07100.1|",528,{"v":4e-59,"d":"4.00E-59"},"rCG38177, isoform CRA_a [Rattus norvegicus]","gi|451958139|ref|NM_001276434.1|",1206,0,"Rattus norvegicus high mobility group nucleosome binding domain 5 (Hmgn5), mRNA","B4F777",207,{"v":2e-60,"d":"2.00E-60"},"High mobility group nucleosome-binding domain-containing protein 5",".",".",".",".","pfam01101","HMG14_17","HMG14 and HMG17.",".",".",".",".","."]
["ENSRNOG00000039494",21,1.743559871,85,5.468087246,0.318861019,-1.649000357,{"v":1.32923e-07,"d":"1.33E-07"},{"v":2.22844e-07,"d":"2.23E-07"},"down","yes","Aass","protein_coding","chr4:51606462-51663136:-","gi|155369281|ref|NP_001094433.1|",4813,0,"alpha-aminoadipic semialdehyde synthase, mitochondrial precursor [Rattus norvegicus]","gi|155369280|ref|NM_001100963.1|",3272,0,"Rattus norvegicus aminoadipate-semialdehyde synthase (Aass), mRNA","A2VCW9",1858,0,"Alpha-aminoadipic semialdehyde synthase, mitochondrial","YNR050c",322,{"v":8e-98,"d":"8.00E-98"},"COG1748","pfam03435","Saccharop_dh","Saccharopine dehydrogenase. This family comprised of three structural domains that can not be separated in the linear sequence. In some organisms this enzyme is found as a bifunctional polypeptide with lysine ketoglutarate reductase. The saccharopine dehydrogenase can also function as a saccharopine reductase.","GO:0008150|biological_process;GO:0019477|L-lysine catabolic process;GO:0019878|lysine biosynthetic process via aminoadipic acid;GO:0033512|L-lysine catabolic process to acetyl-CoA via saccharopine;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0043231|intracellular membrane-bounded organelle;","GO:0003674|molecular_function;GO:0004753|saccharopine dehydrogenase activity;GO:0047130|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity;GO:0047131|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity;","K14157","AASS; alpha-aminoadipic semialdehyde synthase [EC:1.5.1.8 1.5.1.9]"]
["ENSRNOG00000004647",15,1.245399908,71,4.567461111,0.272667873,-1.874783368,{"v":1.35966e-07,"d":"1.36E-07"},{"v":2.27481E-7,"d":"2.27E-07"},"down","yes","Il10","protein_coding","chr13:42472839-42477313:+","gi|148747382|ref|NP_036986.2|",910,{"v":7e-119,"d":"7.00E-119"},"interleukin-10 precursor [Rattus norvegicus]","gi|296620|emb|X60675.1|",1274,0,"R.norvegicus mRNA for interleukin 10","P29456",355,{"v":2E-120,"d":"2.00E-120"},"Interleukin-10",".",".",".",".","pfam00726","IL10","Interleukin 10.","GO:0001818|negative regulation of cytokine production;GO:0001819|positive regulation of cytokine production;GO:0001938|positive regulation of endothelial cell proliferation;GO:0002237|response to molecule of bacterial origin;GO:0002639|positive regulation of immunoglobulin production;GO:0002719|negative regulation of cytokine production involved in immune response;GO:0002875|negative regulation of chronic inflammatory response to antigenic stimulus;GO:0002904|positive regulation of B cell apoptotic process;GO:0006955|immune response;GO:0007165|signal transduction;GO:0007568|aging;GO:0008285|negative regulation of cell proliferation;GO:0009410|response to xenobiotic stimulus;GO:0010033|response to organic substance;GO:0010468|regulation of gene expression;GO:0010507|negative regulation of autophagy;GO:0014823|response to activity;GO:0014854|response to inactivity;GO:0030886|negative regulation of myeloid dendritic cell activation;GO:0030889|negative regulation of B cell proliferation;GO:0032496|response to lipopolysaccharide;GO:0032689|negative regulation of interferon-gamma production;GO:0032695|negative regulation of interleukin-12 production;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032868|response to insulin;GO:0034115|negative regulation of heterotypic cell-cell adhesion;GO:0034465|response to carbon monoxide;GO:0035729|cellular response to hepatocyte growth factor stimulus;GO:0042742|defense response to bacterium;GO:0042832|defense response to protozoan;GO:0043032|positive regulation of macrophage activation;GO:0043066|negative regulation of apoptotic process;GO:0043524|negative regulation of neuron apoptotic process;GO:0045019|negative regulation of nitric oxide biosynthetic process;GO:0045347|negative regulation of MHC class II biosynthetic process;GO:0045348|positive regulation of MHC class II biosynthetic process;GO:0045787|positive regulation of cell cycle;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046427|positive regulation of JAK-STAT cascade;GO:0050728|negative regulation of inflammatory response;GO:0050807|regulation of synapse organization;GO:0051045|negative regulation of membrane protein ectodomain proteolysis;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051384|response to glucocorticoid;GO:0051930|regulation of sensory perception of pain;GO:0060302|negative regulation of cytokine activity;GO:0060670|branching involved in labyrinthine layer morphogenesis;GO:0071222|cellular response to lipopolysaccharide;GO:0071392|cellular response to estradiol stimulus;GO:0097421|liver regeneration;GO:1900100|positive regulation of plasma cell differentiation;GO:1902895|positive regulation of pri-miRNA transcription by RNA polymerase II;GO:1903034|regulation of response to wounding;GO:1903208|negative regulation of hydrogen peroxide-induced neuron death;GO:1903672|positive regulation of sprouting angiogenesis;GO:1904057|negative regulation of sensory perception of pain;GO:1904706|negative regulation of vascular smooth muscle cell proliferation;GO:2000273|positive regulation of signaling receptor activity;GO:2000352|negative regulation of endothelial cell apoptotic process;","GO:0005615|extracellular space;","GO:0005125|cytokine activity;GO:0005141|interleukin-10 receptor binding;GO:0046983|protein dimerization activity;","K05443","IL10, CSIF; interleukin 10"]
["ENSRNOG00000070558",15,1.245399908,71,4.567461111,0.272667873,-1.874783368,{"v":1.35966e-07,"d":"1.36E-07"},{"v":2.27481E-7,"d":"2.27E-07"},"down","yes","ENSRNOG00000070558","protein_coding","chr15:36677527-36701211:-","gi|568900759|ref|XP_006543249.1|",1599,0,"PREDICTED: uncharacterized protein Gm4131 [Mus musculus]","gi|672078538|ref|XM_006252194.2|",1631,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102554746 (LOC102554746), mRNA",".",".",".",".",".",".",".",".","pfam03925","SeqA","SeqA protein. The binding of SeqA protein to hemimethylated GATC sequences is important in the negative modulation of chromosomal initiation at oriC, and in the formation of SeqA foci necessary for Escherichia coli chromosome segregation. SeqA tetramers are able to aggregate or multimerize in a reversible, concentration-dependent manner. Apart from its function in the control of DNA replication, SeqA may also be a specific transcription factor.",".",".",".",".","."]
["ENSRNOG00000020655",5,0.415133303,44,2.83053928,0.146662265,-2.769430368,{"v":1.53005e-07,"d":"1.53E-07"},{"v":2.54906e-07,"d":"2.55E-07"},"down","yes","Ucn2","protein_coding","chr8:109638285-109639172:+","gi|254675174|ref|NP_596876.2|",360,{"v":3e-39,"d":"3.00E-39"},"urocortin-2 precursor [Rattus norvegicus]","gi|254675173|ref|NM_133385.2|",882,0,"Rattus norvegicus urocortin 2 (Ucn2), mRNA","Q91WW1",141,{"v":6e-40,"d":"6.00E-40"},"Urocortin-2",".",".",".",".","pfam11613","UCN2","Agonist of corticotropin releasing factor R2, Urocortin-2. This family of proteins represents urocortin 2, a member of the corticoliberin family which is a selective agnonist of corticotropin releasing factor 2. The backbone of the protein is mainly alpha-helical but it contains a helix-loop-helix motif.","GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007586|digestion;GO:0008283|cell proliferation;GO:0009755|hormone-mediated signaling pathway;GO:0010629|negative regulation of gene expression;GO:0031669|cellular response to nutrient levels;GO:0033685|negative regulation of luteinizing hormone secretion;GO:0035902|response to immobilization stress;GO:0042246|tissue regeneration;GO:0046882|negative regulation of follicle-stimulating hormone secretion;GO:0071385|cellular response to glucocorticoid stimulus;GO:0071456|cellular response to hypoxia;","GO:0005615|extracellular space;","GO:0001664|G protein-coupled receptor binding;GO:0005179|hormone activity;GO:0042562|hormone binding;GO:0051429|corticotropin-releasing hormone receptor binding;GO:0051431|corticotropin-releasing hormone receptor 2 binding;","K05257","UCN2_3; urocortin 2/3"]
["ENSRNOG00000017521",65,5.396732934,172,11.06483537,0.487737301,-1.035823785,{"v":1.59121e-07,"d":"1.59E-07"},{"v":2.6482e-07,"d":"2.65E-07"},"down","yes","Gpr55","protein_coding","chr9:86590885-86640613:-","gi|564311905|ref|XP_006226976.1|",1624,0,"PREDICTED: G-protein coupled receptor 55 isoform X2 [Rattus norvegicus]","gi|672024239|ref|XM_006226917.2|",2470,0,"PREDICTED: Rattus norvegicus G protein-coupled receptor 55 (Gpr55), transcript variant X4, mRNA","Q3UJF0",488,{"v":6e-165,"d":"6.00E-165"},"G-protein coupled receptor 55",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007202|activation of phospholipase C activity;GO:0035025|positive regulation of Rho protein signal transduction;GO:0038171|cannabinoid signaling pathway;GO:0045453|bone resorption;GO:0045671|negative regulation of osteoclast differentiation;GO:0051482|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;","GO:0005887|integral component of plasma membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004949|cannabinoid receptor activity;","K08413","GPR55; G protein-coupled receptor 55"]
["ENSRNOG00000030160",16,1.328426568,73,4.696121987,0.282877355,-1.821751403,{"v":1.59618e-07,"d":"1.60E-07"},{"v":2.65508E-7,"d":"2.66E-07"},"down","yes","Zfp819","protein_coding","chr1:94035679-94048760:+","gi|62078765|ref|NP_001014039.1|",3272,0,"zinc finger protein 175 [Rattus norvegicus]","gi|672036387|ref|XM_006229044.2|",2338,0,"PREDICTED: Rattus norvegicus zinc finger protein 819 (Zfp819), transcript variant X4, mRNA","Q9Y473",584,0,"Zinc finger protein 175",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;GO:0043065|positive regulation of apoptotic process;GO:0045892|negative regulation of transcription, DNA-templated;","GO:0005634|nucleus;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0046872|metal ion binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSRNOG00000016046",20,1.66053321,82,5.275095931,0.314787301,-1.667550754,{"v":1.76699e-07,"d":"1.77E-07"},{"v":2.9293e-07,"d":"2.93E-07"},"down","yes","Hecw1","protein_coding","chr17:50670954-51080720:+","gi|672081938|ref|XP_008769919.1|",7773,0,"PREDICTED: E3 ubiquitin-protein ligase HECW1 isoform X1 [Rattus norvegicus]","gi|672081937|ref|XM_008771697.1|",5096,0,"PREDICTED: Rattus norvegicus HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 (Hecw1), transcript variant X1, mRNA","Q8K4P8",2876,0,"E3 ubiquitin-protein ligase HECW1","SPBC16E9.11c",384,{"v":9e-114,"d":"9.00E-114"},"COG5021","pfam00632","HECT","HECT-domain (ubiquitin-transferase). The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.","GO:0000209|protein polyubiquitination;GO:0016567|protein ubiquitination;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045732|positive regulation of protein catabolic process;GO:0048814|regulation of dendrite morphogenesis;GO:2000650|negative regulation of sodium ion transmembrane transporter activity;","GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0016874|ligase activity;GO:0061630|ubiquitin protein ligase activity;","K12167","HECW1; E3 ubiquitin-protein ligase HECW1 [EC:2.3.2.26]"]
["ENSRNOG00000033763",13,1.079346587,65,4.181478482,0.258125587,-1.953854939,{"v":2.16976E-7,"d":"2.17E-07"},{"v":3.56742e-07,"d":"3.57E-07"},"down","yes","RGD1307537","protein_coding","chr17:29929780-29966579:-","gi|149045215|gb|EDL98301.1|",1064,{"v":8e-144,"d":"8.00E-144"},"similar to RIKEN cDNA 4933417A18 [Rattus norvegicus]","gi|50927387|gb|BC079269.1|",695,0,"Rattus norvegicus similar to RIKEN cDNA 4933417A18, mRNA (cDNA clone MGC:94380 IMAGE:7133712), complete cds","Q6AXY2",413,{"v":8e-145,"d":"8.00E-145"},"Uncharacterized protein C6orf201 homolog",".",".",".",".","pfam15023","DUF4523","Protein of unknown function (DUF4523). This family of proteins is functionally uncharacterized. This family of proteins is found in mammals.",".",".","GO:0003676|nucleic acid binding;",".","."]
["ENSRNOG00000064277",7,0.581186624,49,3.152191471,0.184375419,-2.439281766,{"v":2.39098e-07,"d":"2.39E-07"},{"v":3.90902e-07,"d":"3.91E-07"},"down","yes","ENSRNOG00000064277","lncRNA","chr1:154032905-154040564:+","gi|148692777|gb|EDL24724.1|",142,5e-07,"interleukin 17 receptor D [Mus musculus]","gi|51372035|gb|AC115040.7|",992,0,"Mus musculus chromosome 7, clone RP24-281E19, complete sequence",".",".",".",".",".",".",".",".","pfam03224","V-ATPase_H_N","V-ATPase subunit H. The yeast Saccharomyces cerevisiae vacuolar H+-ATPase (V-ATPase) is a multisubunit complex responsible for acidifying organelles. It functions as an ATP dependent proton pump that transports protons across a lipid bilayer. This domain corresponds to the N terminal domain of the H subunit of V-ATPase. The N-terminal domain is required for the activation of the complex whereas the C-terminal domain is required for coupling ATP hydrolysis to proton translocation.",".",".",".",".","."]
["ENSRNOG00000027949",6,0.498159963,46,2.959200157,0.168342774,-2.570526299,{"v":2.52135E-7,"d":"2.52E-07"},{"v":4.10955e-07,"d":"4.11E-07"},"down","yes","Rfx6","protein_coding","chr20:31019829-31073147:+","gi|564397930|ref|XP_006256506.1|",4823,0,"PREDICTED: DNA-binding protein RFX6 isoform X2 [Rattus norvegicus]","gi|672086182|ref|XM_006256444.2|",3396,0,"PREDICTED: Rattus norvegicus regulatory factor X, 6 (Rfx6), transcript variant X2, mRNA","Q8C7R7",1716,0,"DNA-binding protein RFX6",".",".",".",".","pfam02257","RFX_DNA_binding","RFX DNA-binding domain. RFX is a regulatory factor which binds to the X box of MHC class II genes and is essential for their expression. The DNA-binding domain of RFX is the central domain of the protein and binds ssDNA as either a monomer or homodimer. It recognize X-boxes (DNA of the sequence 5'-GTNRCC(0-3N)RGYAAC-3', where N is any nucleotide, R is a purine and Y is a pyrimidine) using a highly conserved 76-residue DNA-binding domain (DBD).","GO:0003309|type B pancreatic cell differentiation;GO:0003310|pancreatic A cell differentiation;GO:0003311|pancreatic D cell differentiation;GO:0006357|regulation of transcription by RNA polymerase II;GO:0031018|endocrine pancreas development;GO:0035774|positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0042593|glucose homeostasis;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050796|regulation of insulin secretion;GO:0090104|pancreatic epsilon cell differentiation;","GO:0005634|nucleus;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;","K19521","RFX6; regulatory factor X 6"]
["ENSRNOG00000013017",52,4.317386347,146,9.392243975,0.459675703,-1.121311685,{"v":2.59139E-7,"d":"2.59E-07"},{"v":4.21618e-07,"d":"4.22E-07"},"down","yes","Arnt2","protein_coding","chr1:138189940-138393153:-","gi|1470080|gb|AAB05247.1|",2892,0,"aryl hydrocarbon receptor nuclear translocator 2, partial [Rattus norvegicus]","gi|672037414|ref|XM_008759608.1|",4960,0,"PREDICTED: Rattus norvegicus aryl hydrocarbon receptor nuclear translocator 2 (Arnt2), transcript variant X12, mRNA","Q78E60",1117,0,"Aryl hydrocarbon receptor nuclear translocator 2","all0219_1",55.8,1e-07,"COG2202","pfam14598","PAS_11","PAS domain. This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).","GO:0001666|response to hypoxia;GO:0001701|in utero embryonic development;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007417|central nervous system development;GO:0007420|brain development;GO:0008284|positive regulation of cell proliferation;GO:0032355|response to estradiol;GO:0043066|negative regulation of apoptotic process;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005737|cytoplasm;GO:0034751|aryl hydrocarbon receptor complex;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0017162|aryl hydrocarbon receptor binding;GO:0044877|protein-containing complex binding;GO:0046982|protein heterodimerization activity;GO:1990837|sequence-specific double-stranded DNA binding;","K15589","ARNT2; aryl hydrocarbon receptor nuclear translocator 2"]
["ENSRNOG00000067278",65,5.396732934,170,10.93617449,0.493475387,-1.018949967,{"v":2.72936E-7,"d":"2.73E-07"},{"v":4.43052e-07,"d":"4.43E-07"},"down","yes","ENSRNOG00000067278","protein_coding","chr1:163050070-163051381:+","gi|148673911|gb|EDL05858.1|",922,{"v":1E-119,"d":"1.00E-119"},"mCG144566, partial [Mus musculus]","gi|694953645|ref|XM_509611.5|",878,0,"PREDICTED: Pan troglodytes high mobility group box 1 (HMGB1), transcript variant X1, mRNA","P63159",305,{"v":3e-100,"d":"3.00E-100"},"High mobility group protein B1","YBR089c-a",61.2,{"v":1E-10,"d":"1.00E-10"},"COG5648","pfam09011","HMG_box_2","HMG-box domain. This short 71 residue domain is an HMG-box domain. HMG-box domains mediate re-modelling of chromatin-structure. Mammalian HMG-box proteins are of two types: those that are non-sequence-specific DNA-binding proteins with two HMG-box domains and a long highly acidic C-tail; and a diverse group of sequence-specific transcription factor-proteins with either a single HMG-box or up to six copies, and no acidic C-tail.",".",".",".",".","."]
["ENSRNOG00000031662",17,1.411453229,74,4.760452426,0.296495606,-1.753917368,{"v":2.74061e-07,"d":"2.74E-07"},{"v":4.44765E-7,"d":"4.45E-07"},"down","yes","Slc6a5","protein_coding","chr1:99645389-99697010:+","gi|978128196|sp|P58295.2|SC6A5_RAT",4048,0,"RecName: Full=Sodium- and chloride-dependent glycine transporter 2; Short=GlyT-2; Short=GlyT2; AltName: Full=Solute carrier family 6 member 5","gi|42627862|ref|NM_203334.1|",7029,0,"Rattus norvegicus solute carrier family 6 (neurotransmitter transporter), member 5 (Slc6a5), mRNA","P58295",1565,0,"Sodium- and chloride-dependent glycine transporter 2","BH3439",212,{"v":4e-57,"d":"4.00E-57"},"COG0733","pfam00209","SNF","Sodium:neurotransmitter symporter family.","GO:0001504|neurotransmitter uptake;GO:0015816|glycine transport;GO:0035725|sodium ion transmembrane transport;GO:0060012|synaptic transmission, glycinergic;GO:0098810|neurotransmitter reuptake;GO:1903804|glycine import across plasma membrane;","GO:0005768|endosome;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0031045|dense core granule;GO:0098690|glycinergic synapse;GO:0099056|integral component of presynaptic membrane;","GO:0015187|glycine transmembrane transporter activity;GO:0015375|glycine:sodium symporter activity;GO:0046872|metal ion binding;","K05038","SLC6A5_9, GLYT; solute carrier family 6 (neurotransmitter transporter, glycine) member 5/9"]
["ENSRNOG00000004578",63,5.230679613,166,10.67885274,0.489816626,-1.029686352,{"v":2.9852E-7,"d":"2.99E-07"},{"v":4.83111e-07,"d":"4.83E-07"},"down","yes","Cthrc1","protein_coding","chr7:70122474-70132756:+","gi|149066481|gb|EDM16354.1|",1305,{"v":1e-177,"d":"1.00E-177"},"collagen triple helix repeat containing 1 [Rattus norvegicus]","gi|404351656|ref|NM_172333.2|",1216,0,"Rattus norvegicus collagen triple helix repeat containing 1 (Cthrc1), transcript variant 1, mRNA","Q8CG08",468,{"v":4e-164,"d":"4.00E-164"},"Collagen triple helix repeat-containing protein 1",".",".",".",".","pfam01391","Collagen","Collagen triple helix repeat (20 copies). Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxyproline. Collagens are post translationally modified by proline hydroxylase to form the hydroxyproline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure.","GO:0016477|cell migration;GO:0032092|positive regulation of protein binding;GO:0033690|positive regulation of osteoblast proliferation;GO:0043932|ossification involved in bone remodeling;GO:0045669|positive regulation of osteoblast differentiation;GO:0060071|Wnt signaling pathway, planar cell polarity pathway;GO:0060122|inner ear receptor cell stereocilium organization;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0090103|cochlea morphogenesis;GO:0090177|establishment of planar polarity involved in neural tube closure;","GO:0005581|collagen trimer;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0031012|extracellular matrix;","GO:0005109|frizzled binding;GO:0017147|Wnt-protein binding;","K25700","CTHRC1; collagen triple helix repeat-containing protein 1"]
["ENSRNOG00000002212",67,5.562786255,173,11.12916581,0.499838564,-1.000465881,{"v":3.24458e-07,"d":"3.24E-07"},{"v":5.23232e-07,"d":"5.23E-07"},"down","yes","Hsd17b13","protein_coding","chr14:5752132-5768166:+","gi|57527356|ref|NP_001009684.1|",1514,0,"17-beta-hydroxysteroid dehydrogenase 13 precursor [Rattus norvegicus]","gi|57527355|ref|NM_001009684.1|",1297,0,"Rattus norvegicus hydroxysteroid (17-beta) dehydrogenase 13 (Hsd17b13), mRNA","Q5M875",587,0,"17-beta-hydroxysteroid dehydrogenase 13","all0968",114,{"v":1E-27,"d":"1.00E-27"},"COG1028","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.","GO:0046889|positive regulation of lipid biosynthetic process;","GO:0005783|endoplasmic reticulum;GO:0005811|lipid droplet;","GO:0016229|steroid dehydrogenase activity;GO:0016616|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;",".","."]
["ENSRNOG00000010736",33,2.739879797,108,6.947687324,0.394358535,-1.342420227,{"v":3.31812e-07,"d":"3.32E-07"},{"v":5.34688e-07,"d":"5.35E-07"},"down","yes","Pbx4","protein_coding","chr16:19555090-19590014:-","gi|157822083|ref|NP_001101869.1|",1821,0,"pre-B-cell leukemia transcription factor 4 [Rattus norvegicus]","gi|157822082|ref|NM_001108399.1|",1384,0,"Rattus norvegicus pre-B-cell leukemia homeobox 4 (Pbx4), mRNA","Q99NE9",632,0,"Pre-B-cell leukemia transcription factor 4",".",".",".",".","pfam03792","PBC","PBC domain. The PBC domain is a member of the TALE (three-amino-acid loop extension) superclass of homeodomain proteins.","GO:0001654|eye development;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007420|brain development;GO:0009887|animal organ morphogenesis;GO:0048568|embryonic organ development;GO:0048666|neuron development;","GO:0001741|XY body;GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565|sequence-specific DNA binding;","K15611","PBX4; pre-B-cell leukemia transcription factor 4"]
["ENSRNOG00000062383",53,4.400413008,147,9.456574413,0.465328439,-1.103678734,{"v":3.34534e-07,"d":"3.35E-07"},{"v":5.38666e-07,"d":"5.39E-07"},"down","yes","Dio2","protein_coding","chr6:109665523-109679809:-","gi|132566529|ref|NP_113908.3|",1398,{"v":1E-174,"d":"1.00E-174"},"type II iodothyronine deiodinase [Rattus norvegicus]","gi|2959448|dbj|AB011068.1|",3423,0,"Rattus rattus mRNA for type II iodothyronine deiodinase, complete cds","P70551",543,{"v":4E-176,"d":"4.00E-176"},"Type II iodothyronine deiodinase",".",".",".",".","pfam00837","T4_deiodinase","Iodothyronine deiodinase. Iodothyronine deiodinase converts thyroxine (T4) to 3,5,3'-triiodothyronine (T3).",".",".",".",".","."]
["ENSRNOG00000009863",16,1.328426568,71,4.567461111,0.290845732,-1.781673963,{"v":3.57443e-07,"d":"3.57E-07"},{"v":5.73533e-07,"d":"5.74E-07"},"down","yes","Prrt3","protein_coding","chr4:146641173-146650317:-","gi|827475627|ref|NP_001296392.1|",3176,0,"proline-rich transmembrane protein 3 precursor [Rattus norvegicus]","gi|827475626|ref|NM_001309463.1|",4342,0,"Rattus norvegicus proline-rich transmembrane protein 3 (Prrt3), mRNA","Q6PE13",1059,0,"Proline-rich transmembrane protein 3",".",".",".",".","pfam05518","Totivirus_coat","Totivirus coat protein.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000069950",0,0.04151333,27,1.736921831,0.023900517,-5.386814346,{"v":3.74557e-07,"d":"3.75E-07"},{"v":5.99789e-07,"d":"6.00E-07"},"down","yes","ENSRNOG00000069950","lncRNA","chr1:244135543-244141053:+","gi|37654282|gb|AAQ96246.1|",1450,0,"LRRGT00033 [Rattus norvegicus]","gi|969987293|gb|KU095826.1|",3682,0,"Rattus norvegicus strain SHR.BN-D1Mit3/Igf2 folate receptor 1 (FOLr1) gene, promoter region","P11227",503,0,"Gag-Pol polyprotein","SPAC167.08",78.6,{"v":2e-13,"d":"2.00E-13"},"COG2801","pfam02093","Gag_p30","Gag P30 core shell protein. According to Swiss-Prot annotation this protein is the viral core shell protein. P30 is essential for viral assembly.",".",".",".",".","."]
["ENSRNOG00000050123",4,0.332106642,39,2.508887089,0.132372096,-2.917329063,{"v":3.89808e-07,"d":"3.90E-07"},{"v":6.23429e-07,"d":"6.23E-07"},"down","yes","Gdf5","protein_coding","chr3:144454338-144458612:-","gi|109471161|ref|XP_001066344.1|",2260,0,"PREDICTED: growth/differentiation factor 5 [Rattus norvegicus]","gi|672017615|ref|XM_001066344.5|",2327,0,"PREDICTED: Rattus norvegicus growth differentiation factor 5 (Gdf5), mRNA","P43027",849,0,"Growth/differentiation factor 5",".",".",".",".","pfam00019","TGF_beta","Transforming growth factor beta like domain.","GO:0007178|transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0009612|response to mechanical stimulus;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0030326|embryonic limb morphogenesis;GO:0030509|BMP signaling pathway;GO:0030513|positive regulation of BMP signaling pathway;GO:0032331|negative regulation of chondrocyte differentiation;GO:0032332|positive regulation of chondrocyte differentiation;GO:0035136|forelimb morphogenesis;GO:0035137|hindlimb morphogenesis;GO:0040014|regulation of multicellular organism growth;GO:0043524|negative regulation of neuron apoptotic process;GO:0043932|ossification involved in bone remodeling;GO:0045666|positive regulation of neuron differentiation;GO:0050680|negative regulation of epithelial cell proliferation;GO:0060390|regulation of SMAD protein signal transduction;GO:0060395|SMAD protein signal transduction;GO:0060591|chondroblast differentiation;GO:2001054|negative regulation of mesenchymal cell apoptotic process;","GO:0005575|cellular_component;GO:0005615|extracellular space;","GO:0005102|signaling receptor binding;GO:0005125|cytokine activity;GO:0008083|growth factor activity;GO:0036122|BMP binding;GO:0042802|identical protein binding;","K04664","GDF5; growth differentiation factor 5"]
["ENSRNOG00000067344",55,4.566466329,150,9.649565728,0.473230242,-1.079385821,{"v":4.13817e-07,"d":"4.14E-07"},{"v":6.60178e-07,"d":"6.60E-07"},"down","yes","ENSRNOG00000067344","protein_coding","chr9:113440157-113676688:+","gi|672070366|ref|XP_008766739.1|",2337,0,"PREDICTED: zinc finger protein 431-like isoform X3 [Rattus norvegicus]","gi|672018984|ref|XR_600914.1|",1708,0,"PREDICTED: Rattus norvegicus zinc finger protein 120-like (LOC102557117), misc_RNA","Q6P3V2",673,0,"Zinc finger protein 585A",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000064160",2,0.166053321,32,2.058574022,0.080664246,-3.631926844,{"v":4.29512e-07,"d":"4.30E-07"},{"v":6.8385e-07,"d":"6.84E-07"},"down","yes","ENSRNOG00000064160","lncRNA","chr1:39020173-39029307:-","gi|672033170|ref|XP_008756361.1|",348,{"v":1e-37,"d":"1.00E-37"},"PREDICTED: LOW QUALITY PROTEIN: T-cell activation Rho GTPase-activating protein-like [Rattus norvegicus]","gi|672012669|ref|XR_598633.1|",325,{"v":2e-168,"d":"2.00E-168"},"PREDICTED: Rattus norvegicus rho GTPase-activating protein 20-like (LOC102556805), transcript variant X8, misc_RNA",".",".",".",".",".",".",".",".","pfam06398","Pex24p","Integral peroxisomal membrane peroxin. Peroxisomes play diverse roles in the cell, compartmentalising many activities related to lipid metabolizm and functioning in the decomposition of toxic hydrogen peroxide. Sequence similarity was identified between two hypothetical proteins and the peroxin integral membrane protein Pex24p.",".",".",".",".","."]
["ENSRNOG00000016505",29,2.407773155,99,6.36871338,0.378062728,-1.403302469,{"v":4.30082E-7,"d":"4.30E-07"},{"v":6.84588e-07,"d":"6.85E-07"},"down","yes","Fam169a","protein_coding","chr2:28383784-28438910:+","gi|564299653|ref|XP_006224049.1|",2980,0,"PREDICTED: soluble lamin-associated protein of 75 kDa isoform X1 [Rattus norvegicus]","gi|672041296|ref|XM_006231831.2|",2455,0,"PREDICTED: Rattus norvegicus family with sequence similarity 169, member A (Fam169a), transcript variant X1, mRNA","Q5XG69",1018,0,"Soluble lamin-associated protein of 75 kDa",".",".",".",".","pfam07223","DUF1421","Protein of unknown function (DUF1421). This family represents a conserved region approximately 350 residues long within a number of plant proteins of unknown function.",".",".",".",".","."]
["ENSRNOG00000017954",59,4.898572971,157,10.0998788,0.485013045,-1.043904543,{"v":4.65753e-07,"d":"4.66E-07"},{"v":7.38609e-07,"d":"7.39E-07"},"down","yes","Prelid3a","protein_coding","chr18:61017764-61031883:+","gi|149064529|gb|EDM14732.1|",958,{"v":5e-122,"d":"5.00E-122"},"rCG46806, isoform CRA_c [Rattus norvegicus]","gi|672083568|ref|XM_006254886.2|",1478,0,"PREDICTED: Rattus norvegicus slowmo homolog 1 (Drosophila) (Slmo1), transcript variant X3, mRNA","Q8VE85",348,{"v":2e-114,"d":"2.00E-114"},"PRELI domain containing protein 3A",".",".",".",".","pfam04707","PRELI","PRELI-like family. This family includes a conserved region found in the PRELI protein and yeast YLR168C gene MSF1 product. The function of this protein is unknown, though it is thought to be involved in intra-mitochondrial protein sorting. This region is also found in a number of other eukaryotic proteins.","GO:0015914|phospholipid transport;GO:0120009|intermembrane lipid transfer;","GO:0005758|mitochondrial intermembrane space;","GO:1990050|phosphatidic acid transporter activity;",".","."]
["ENSRNOG00000070030",28,2.324746495,96,6.175722066,0.376433147,-1.409534422,{"v":5.89382e-07,"d":"5.89E-07"},{"v":9.24576e-07,"d":"9.25E-07"},"down","yes","ENSRNOG00000070030","lncRNA","chr1:73565662-73568411:+","gi|68063179|ref|XP_673599.1|",179,{"v":4e-12,"d":"4.00E-12"},"hypothetical protein [Plasmodium berghei strain ANKA] [Plasmodium berghei ANKA]","gi|354787663|gb|JN952164.1|",169,{"v":7e-81,"d":"7.00E-81"},"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Sort1:tm1e(EUCOMM)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices",".",".",".",".","."]
["ENSRNOG00000005269",43,3.570146403,126,8.105635211,0.44045239,-1.182942013,{"v":5.89714e-07,"d":"5.90E-07"},{"v":9.24869e-07,"d":"9.25E-07"},"down","yes","Srl","protein_coding","chr10:11034035-11078101:+","gi|392351018|ref|XP_003750819.1|",3740,0,"PREDICTED: sarcalumenin isoform X1 [Rattus norvegicus]","gi|672066674|ref|XM_003750771.3|",5040,0,"PREDICTED: Rattus norvegicus sarcalumenin (Srl), transcript variant X1, mRNA","Q7TQ48",1282,0,"Sarcalumenin",".",".",".",".","pfam00350","Dynamin_N","Dynamin family.","GO:0002115|store-operated calcium entry;GO:0006897|endocytosis;GO:0014873|response to muscle activity involved in regulation of muscle adaptation;GO:0016197|endosomal transport;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0005525|GTP binding;",".","."]
["ENSRNOG00000051405",42,3.487119742,124,7.976974335,0.437148171,-1.193805731,{"v":6.01124e-07,"d":"6.01E-07"},{"v":9.41361e-07,"d":"9.41E-07"},"down","yes","AABR07021465.1","protein_coding","chr13:68458411-68544172:-","gi|672027354|ref|XP_008761118.1|",4258,0,"PREDICTED: axonemal dynein light chain domain-containing protein 1 isoform X1 [Rattus norvegicus]","gi|755471695|ref|XM_011251715.1|",2153,0,"PREDICTED: Mus musculus axonemal dynein light chain domain containing 1 (Axdnd1), mRNA",".",".",".",".",".",".",".",".","pfam10211","Ax_dynein_light","Axonemal dynein light chain. Axonemal dynein light chain proteins play a dynamic role in flagellar and cilia motility. Eukaryotic cilia and flagella are complex organelles consisting of a core structure, the axoneme, which is composed of nine microtubule doublets forming a cylinder that surrounds a pair of central singlet microtubules. This ultra-structural arrangement seems to be one of the most stable micro-tubular assemblies known and is responsible for the flagellar and ciliary movement of a large number of organisms ranging from protozoan to mammals. This light chain interacts directly with the N-terminal half of the heavy chains.",".",".",".",".","."]
["ENSRNOG00000070234",32,2.656853137,104,6.690365571,0.397116287,-1.332366562,{"v":6.3533e-07,"d":"6.35E-07"},{"v":9.92031E-7,"d":"9.92E-07"},"down","yes","Zfp141","protein_coding","chr1:93130598-93163404:+","gi|564297338|ref|XP_006223288.1|",4042,0,"PREDICTED: zinc finger protein 2-like [Rattus norvegicus]","gi|564297337|ref|XM_006223226.1|",2756,0,"PREDICTED: Rattus norvegicus zinc finger protein 141 (Zfp141), mRNA","Q9HCG1",544,{"v":3e-178,"d":"3.00E-178"},"Zinc finger protein 160",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000004754",50,4.151333026,139,8.941930908,0.464254653,-1.107011727,{"v":6.55216e-07,"d":"6.55E-07"},{"v":1.02158E-6,"d":"1.02E-06"},"down","yes","Tc2n","protein_coding","chr6:120761119-120849326:-","gi|68342017|ref|NP_001020323.1|",2419,0,"tandem C2 domains nuclear protein [Rattus norvegicus]","gi|672056732|ref|XM_008764834.1|",2396,0,"PREDICTED: Rattus norvegicus tandem C2 domains, nuclear (Tc2n), transcript variant X4, mRNA","Q91XT6",892,0,"Tandem C2 domains nuclear protein",".",".",".",".","pfam00168","C2","C2 domain.",".","GO:0005634|nucleus;",".","K17287","TC2N; tandem C2 domains nuclear protein"]
["ENSRNOG00000068365",25,2.075666513,89,5.725408998,0.362535937,-1.463804085,{"v":7.516e-07,"d":"7.52E-07"},{"v":1.16476E-6,"d":"1.16E-06"},"down","yes","ENSRNOG00000068365","lncRNA","chr4:81647412-81648449:+",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","pfam04082","Fungal_trans","Fungal specific transcription factor domain.",".",".",".",".","."]
["ENSRNOG00000057645",24,1.992639853,86,5.532417684,0.360175237,-1.473229098,{"v":1.0251e-06,"d":"1.03E-06"},{"v":1.56583e-06,"d":"1.57E-06"},"down","yes","Micb","protein_coding","chr1:78495779-78512827:+","gi|62945292|ref|NP_001017468.1|",1532,0,"MHC class I-like located near the LRC, 2 precursor [Rattus norvegicus]","gi|53850435|dbj|AB114034.1|",543,0,"Rattus norvegicus Mill2 gene for MHC class I-like located near the LRC, 2, exon 4, partial cds, strain:PVG","Q9GL42",119,{"v":7e-29,"d":"7.00E-29"},"Hereditary hemochromatosis protein homolog",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.","GO:0002429|immune response-activating cell surface receptor signaling pathway;GO:0006955|immune response;GO:0006979|response to oxidative stress;GO:0009408|response to heat;GO:0032526|response to retinoic acid;GO:0046629|gamma-delta T cell activation;GO:0050689|negative regulation of defense response to virus by host;","GO:0005615|extracellular space;GO:0009897|external side of plasma membrane;GO:0031225|anchored component of membrane;","GO:0046703|natural killer cell lectin-like receptor binding;",".","."]
["ENSRNOG00000038228",26,2.158693174,90,5.789739437,0.37284807,-1.423340222,{"v":1.10608E-6,"d":"1.11E-06"},{"v":1.6827E-6,"d":"1.68E-06"},"down","yes","Serp2","protein_coding","chr15:51879877-51904785:-","gi|568988885|ref|XP_006519662.1|",517,{"v":2e-59,"d":"2.00E-59"},"PREDICTED: stress-associated endoplasmic reticulum protein 2 isoform X1 [Mus musculus]","gi|157819352|ref|NM_001109104.1|",739,0,"Rattus norvegicus stress-associated endoplasmic reticulum protein family member 2 (Serp2), mRNA","Q6TAW2",111,{"v":4e-28,"d":"4.00E-28"},"Stress-associated endoplasmic reticulum protein 2",".",".",".",".","pfam06624","RAMP4","Ribosome associated membrane protein RAMP4. This family consists of several ribosome associated membrane protein RAMP4 (or SERP1) sequences. Stabilisation of membrane proteins in response to stress involves the concerted action of a rescue unit in the ER membrane comprised of SERP1/RAMP4, other components of the translocon, and molecular chaperones in the ER.","GO:0006486|protein glycosylation;GO:0015031|protein transport;GO:0030968|endoplasmic reticulum unfolded protein response;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000056746",5,0.415133303,40,2.573217527,0.161328492,-2.631926844,{"v":1.11124e-06,"d":"1.11E-06"},{"v":1.68934e-06,"d":"1.69E-06"},"down","yes","Tchh","protein_coding","chr2:179109609-179110985:+","gi|672015998|ref|XP_008773413.1|",212,{"v":1e-15,"d":"1.00E-15"},"PREDICTED: trichohyalin isoform X3 [Rattus norvegicus]","gi|672043308|ref|XM_006232820.2|",547,0,"PREDICTED: Rattus norvegicus trichohyalin (Tchh), transcript variant X1, mRNA","P37709",67.4,{"v":8e-11,"d":"8.00E-11"},"Trichohyalin",".",".",".",".","pfam03814","KdpA","Potassium-transporting ATPase A subunit.","GO:0045109|intermediate filament organization;",".","GO:0005509|calcium ion binding;GO:0030674|protein binding, bridging;GO:0046914|transition metal ion binding;","K18626","TCHH; trichohyalin"]
["ENSRNOG00000047848",13,1.079346587,61,3.924156729,0.275051855,-1.862224463,{"v":1.15496e-06,"d":"1.15E-06"},{"v":1.75123E-6,"d":"1.75E-06"},"down","yes","Cbr1","pseudogene","chr11:32908950-32911393:+","gi|564376239|ref|XP_006248171.1|",1585,0,"PREDICTED: carbonyl reductase [NADPH] 1 [Rattus norvegicus]","gi|672070752|ref|XM_006248109.2|",1023,0,"PREDICTED: Rattus norvegicus carbonyl reductase [NADPH] 1-like (LOC102556347), mRNA","P47727",524,0,"Carbonyl reductase [NADPH] 1","all0352",126,{"v":6e-33,"d":"6.00E-33"},"COG1028","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.","GO:0001542|ovulation from ovarian follicle;GO:0006706|steroid catabolic process;GO:0006805|xenobiotic metabolic process;GO:0030855|epithelial cell differentiation;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0032570|response to progesterone;GO:0033574|response to testosterone;GO:0034698|response to gonadotropin;GO:0042373|vitamin K metabolic process;GO:0042376|phylloquinone catabolic process;GO:1905344|prostaglandin catabolic process;GO:2000379|positive regulation of reactive oxygen species metabolic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005902|microvillus;GO:0035003|subapical complex;GO:0043231|intracellular membrane-bounded organelle;","GO:0004090|carbonyl reductase (NADPH) activity;GO:0005515|protein binding;GO:0016491|oxidoreductase activity;GO:0016655|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0047020|15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity;GO:0047021|15-hydroxyprostaglandin dehydrogenase (NADP+) activity;GO:0050221|prostaglandin-E2 9-reductase activity;","K00079","CBR1; carbonyl reductase 1 [EC:1.1.1.184 1.1.1.189 1.1.1.197]"]
["ENSRNOG00000037082",9,0.747239945,51,3.280852347,0.227757871,-2.134427184,{"v":1.16256e-06,"d":"1.16E-06"},{"v":1.76108E-6,"d":"1.76E-06"},"down","yes","Mybphl","protein_coding","chr2:196005325-196018824:+","gi|62078815|ref|NP_001014064.1|",1842,0,"myosin-binding protein H-like [Rattus norvegicus]","gi|62078814|ref|NM_001014042.1|",1306,0,"Rattus norvegicus myosin binding protein H-like (Mybphl), mRNA","Q5PQM4",714,0,"Myosin-binding protein H-like",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0001701|in utero embryonic development;","GO:0030017|sarcomere;GO:0036379|myofilament;",".","K24494","MYBPH; myosin-binding protein H"]
["ENSRNOG00000004708",29,2.407773155,96,6.175722066,0.389877188,-1.358908349,{"v":1.18756E-6,"d":"1.19E-06"},{"v":1.79683e-06,"d":"1.80E-06"},"down","yes","Aard","protein_coding","chr7:83364204-83369317:+","gi|149066401|gb|EDM16274.1|",828,{"v":6e-105,"d":"6.00E-105"},"alanine and arginine rich domain containing protein [Rattus norvegicus]","gi|21489992|ref|NM_145093.1|",1244,0,"Rattus norvegicus alanine and arginine rich domain containing protein (Aard), mRNA","Q91ZF7",217,{"v":4e-66,"d":"4.00E-66"},"Alanine and arginine-rich domain-containing protein",".",".",".",".","pfam00429","TLV_coat","ENV polyprotein (coat polyprotein).","GO:0030324|lung development;","GO:0005575|cellular_component;","GO:0003674|molecular_function;",".","."]
["ENSRNOG00000006956",30,2.490799816,98,6.304382942,0.395090184,-1.339746092,{"v":1.20431e-06,"d":"1.20E-06"},{"v":1.82002e-06,"d":"1.82E-06"},"down","yes","Adamtsl1","protein_coding","chr5:99964486-100918384:+","gi|568927629|ref|XP_006538438.1|",9126,0,"PREDICTED: ADAMTS-like protein 1 isoform X2 [Mus musculus]","gi|672019521|ref|XM_008775991.1|",6227,0,"PREDICTED: Rattus norvegicus ADAMTS-like 1 (Adamtsl1), transcript variant X1, mRNA","Q8BLI0",3318,0,"ADAMTS-like protein 1",".",".",".",".","pfam08686","PLAC","PLAC (protease and lacunin) domain. The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.",".",".",".",".","."]
["ENSRNOG00000000017",34,2.822906458,106,6.819026448,0.413974998,-1.272384457,{"v":1.22449E-6,"d":"1.22E-06"},{"v":1.84615e-06,"d":"1.85E-06"},"down","yes","Steap1","protein_coding","chr4:28276909-28287479:+","gi|157817514|ref|NP_001100099.1|",1712,0,"metalloreductase STEAP1 [Rattus norvegicus]","gi|157817513|ref|NM_001106629.1|",1195,0,"Rattus norvegicus six transmembrane epithelial antigen of the prostate 1 (Steap1), mRNA","Q9CWR7",622,0,"Metalloreductase STEAP1",".",".",".",".","pfam01794","Ferric_reduct","Ferric reductase like transmembrane component. This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane. The Frp1 protein from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake. Cytochrome B-245 heavy chain is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterized by the absence of a functional plasma membrane associated NADPH oxidase. The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease.",".","GO:0005768|endosome;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;",".","K14737","STEAP1; metalloreductase STEAP1 [EC:1.16.1.-]"]
["ENSRNOG00000017420",43,3.570146403,123,7.912643897,0.451195131,-1.148176594,{"v":1.4453E-6,"d":"1.45E-06"},{"v":2.16477E-6,"d":"2.16E-06"},"down","yes","Nudt6","protein_coding","chr2:120290847-120306230:-","gi|31077146|ref|NP_852028.1|",1269,{"v":5e-172,"d":"5.00E-172"},"nucleoside diphosphate-linked moiety X motif 6 precursor [Rattus norvegicus]","gi|31343426|ref|NM_181363.2|",1006,0,"Rattus norvegicus nudix hydrolase 6 (Nudt6), mRNA","P70563",493,{"v":2e-173,"d":"2.00E-173"},"Nucleoside diphosphate-linked moiety X motif 6","BS_yjhB",53.1,1e-07,"COG1051","pfam00293","NUDIX","NUDIX domain.","GO:0008285|negative regulation of cell proliferation;GO:0045786|negative regulation of cell cycle;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;","GO:0035529|NADH pyrophosphatase activity;GO:0047631|ADP-ribose diphosphatase activity;GO:0051287|NAD binding;",".","."]
["ENSRNOG00000022438",12,0.996319926,58,3.731165415,0.267026469,-1.904945338,{"v":1.47106e-06,"d":"1.47E-06"},{"v":2.19975E-6,"d":"2.20E-06"},"down","yes","Jmjd4","protein_coding","chr10:44234549-44240065:+","gi|157786610|ref|NP_001099254.1|",2294,0,"jmjC domain-containing protein 4 [Rattus norvegicus]","gi|157786609|ref|NM_001105784.1|",1281,0,"Rattus norvegicus jumonji domain containing 4 (Jmjd4), mRNA",".",".",".",".",".",".",".",".","pfam13621","Cupin_8","Cupin-like domain. This cupin like domain shares similarity to the JmjC domain.","GO:0018126|protein hydroxylation;GO:0045905|positive regulation of translational termination;","GO:0005737|cytoplasm;","GO:0016706|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;",".","."]
["ENSRNOG00000025074",12,0.996319926,58,3.731165415,0.267026469,-1.904945338,{"v":1.47106e-06,"d":"1.47E-06"},{"v":2.19975E-6,"d":"2.20E-06"},"down","yes","Fgg","protein_coding","chr2:168355013-168362322:+","gi|564336900|ref|XP_006232587.1|",2279,0,"PREDICTED: fibrinogen gamma chain isoform X1 [Rattus norvegicus]","gi|564336899|ref|XM_006232525.1|",1672,0,"PREDICTED: Rattus norvegicus fibrinogen gamma chain (Fgg), transcript variant X1, mRNA","P02680",882,0,"Fibrinogen gamma chain",".",".",".",".","pfam00147","Fibrinogen_C","Fibrinogen beta and gamma chains, C-terminal globular domain.","GO:0007160|cell-matrix adhesion;GO:0009306|protein secretion;GO:0031639|plasminogen activation;GO:0034116|positive regulation of heterotypic cell-cell adhesion;GO:0034622|cellular protein-containing complex assembly;GO:0036345|platelet maturation;GO:0042730|fibrinolysis;GO:0045907|positive regulation of vasoconstriction;GO:0045921|positive regulation of exocytosis;GO:0050714|positive regulation of protein secretion;GO:0051258|protein polymerization;GO:0051592|response to calcium ion;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070527|platelet aggregation;GO:0071347|cellular response to interleukin-1;GO:0071354|cellular response to interleukin-6;GO:0072378|blood coagulation, fibrin clot formation;GO:0090277|positive regulation of peptide hormone secretion;GO:0090331|negative regulation of platelet aggregation;GO:1902042|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:2000352|negative regulation of endothelial cell apoptotic process;","GO:0005577|fibrinogen complex;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005938|cell cortex;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0031091|platelet alpha granule;GO:0045202|synapse;GO:0062023|collagen-containing extracellular matrix;GO:0072562|blood microparticle;","GO:0005102|signaling receptor binding;GO:0005198|structural molecule activity;GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0050839|cell adhesion molecule binding;","K03905","FGG; fibrinogen gamma chain"]
["ENSRNOG00000015148",1,0.083026661,26,1.672591393,0.049639536,-4.332366562,{"v":1.47652e-06,"d":"1.48E-06"},{"v":2.20584E-6,"d":"2.21E-06"},"down","yes","Erc2","protein_coding","chr16:2848620-3670776:+","gi|37360977|ref|NP_808482.2|",4265,0,"ERC protein 2 [Mus musculus]","gi|22138112|gb|AY049038.1|",2851,0,"Rattus norvegicus CAST1 mRNA, complete cds","Q8K3M6",1565,0,"ERC protein 2",".",".",".",".","pfam10174","Cast","RIM-binding protein of the cytomatrix active zone. This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.","GO:0007274|neuromuscular synaptic transmission;GO:0007416|synapse assembly;GO:0016082|synaptic vesicle priming;GO:0048167|regulation of synaptic plasticity;GO:0048790|maintenance of presynaptic active zone structure;GO:0050808|synapse organization;","GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005798|Golgi-associated vesicle;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0030426|growth cone;GO:0032991|protein-containing complex;GO:0042734|presynaptic membrane;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0045202|synapse;GO:0048786|presynaptic active zone;GO:0048788|cytoskeleton of presynaptic active zone;GO:0098831|presynaptic active zone cytoplasmic component;GO:0098978|glutamatergic synapse;GO:0098982|GABA-ergic synapse;","GO:0005515|protein binding;GO:0030165|PDZ domain binding;GO:0044877|protein-containing complex binding;GO:0098882|structural constituent of presynaptic active zone;","K19878","ERC2, CAST; ELKS/RAB6-interacting/CAST family member 2"]
["ENSRNOG00000012878",10,0.830266605,53,3.409513224,0.243514705,-2.037919203,{"v":1.49401e-06,"d":"1.49E-06"},{"v":2.22989e-06,"d":"2.23E-06"},"down","yes","Atp7b","protein_coding","chr16:69951778-70023636:+","gi|564389728|ref|XP_006253408.1|",7593,0,"PREDICTED: copper-transporting ATPase 2 isoform X1 [Rattus norvegicus]","gi|672080488|ref|XM_006253346.2|",6182,0,"PREDICTED: Rattus norvegicus ATPase, Cu++ transporting, beta polypeptide (Atp7b), transcript variant X1, mRNA","Q64535",2794,0,"Copper-transporting ATPase 2","SA2344",605,0,"COG2217","pfam00122","E1-E2_ATPase","E1-E2 ATPase.","GO:0006825|copper ion transport;GO:0006878|cellular copper ion homeostasis;GO:0006882|cellular zinc ion homeostasis;GO:0007595|lactation;GO:0007623|circadian rhythm;GO:0010043|response to zinc ion;GO:0015677|copper ion import;GO:0015680|protein maturation by copper ion transfer;GO:0035434|copper ion transmembrane transport;GO:0046688|response to copper ion;GO:0051208|sequestering of calcium ion;GO:0051591|response to cAMP;GO:0055070|copper ion homeostasis;GO:0060003|copper ion export;GO:0071280|cellular response to copper ion;GO:0071287|cellular response to manganese ion;GO:1990637|response to prolactin;","GO:0005770|late endosome;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005802|trans-Golgi network;GO:0005886|plasma membrane;GO:0005923|bicellular tight junction;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0031410|cytoplasmic vesicle;GO:0032588|trans-Golgi network membrane;GO:0045177|apical part of cell;GO:0048471|perinuclear region of cytoplasm;GO:0070160|tight junction;","GO:0005375|copper ion transmembrane transporter activity;GO:0005507|copper ion binding;GO:0005524|ATP binding;GO:0008270|zinc ion binding;GO:0043682|copper-transporting ATPase activity;","K17686","copA, ctpA, ATP7; P-type Cu+ transporter [EC:7.2.2.8]"]
["ENSRNOG00000069541",10,0.830266605,53,3.409513224,0.243514705,-2.037919203,{"v":1.49401e-06,"d":"1.49E-06"},{"v":2.22989e-06,"d":"2.23E-06"},"down","yes","ENSRNOG00000069541","lncRNA","chr5:123530978-123534173:+",".",".",".",".","gi|21621601|emb|AL607070.19|",222,{"v":1e-110,"d":"1.00E-110"},"Mouse DNA sequence from clone RP23-31C9 on chromosome 4, complete sequence",".",".",".",".",".",".",".",".","pfam02665","Nitrate_red_gam","Nitrate reductase gamma subunit. This family is the gamma subunit of the nitrate reductase enzyme, the gamma subunit is a b-type cytochrome that receives electrons from the quinone pool.  It then transfers these via the iron-sulfur clusters of the beta subunit to the molybdenum cofactor found in the alpha subunit. The nitrate reductase enzyme, EC:1.7.99.4 catalyses the conversion of nitrite to nitrate via the reduction of an acceptor. The nitrate reductase enzyme is composed of three subunits. Nitrate is the most widely used alternative electron acceptor after oxygen.",".",".",".",".","."]
["ENSRNOG00000062817",41,3.404093082,119,7.655322144,0.444670129,-1.169192603,{"v":1.51792E-6,"d":"1.52E-06"},{"v":2.26399E-6,"d":"2.26E-06"},"down","yes","ENSRNOG00000062817","protein_coding","chr9:113819937-113848167:+","gi|672070372|ref|XP_008766741.1|",444,{"v":1E-51,"d":"1.00E-51"},"PREDICTED: zinc finger protein 431-like isoform X2, partial [Rattus norvegicus]","gi|672070371|ref|XM_008768519.1|",323,{"v":3e-167,"d":"3.00E-167"},"PREDICTED: Rattus norvegicus zinc finger protein 120-like (LOC102547688), transcript variant X2, partial mRNA","E9QAG8",118,{"v":2e-30,"d":"2.00E-30"},"Zinc finger protein 431",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000068603",41,3.404093082,119,7.655322144,0.444670129,-1.169192603,{"v":1.51792E-6,"d":"1.52E-06"},{"v":2.26399E-6,"d":"2.26E-06"},"down","yes","ENSRNOG00000068603","lncRNA","chr12:19323608-19326012:-","gi|148701441|gb|EDL33388.1|",210,{"v":2E-16,"d":"2.00E-16"},"mCG1045525, partial [Mus musculus]","gi|755477074|ref|XR_861418.1|",278,{"v":2e-141,"d":"2.00E-141"},"PREDICTED: Mus musculus uncharacterized LOC105242538 (LOC105242538), ncRNA",".",".",".",".",".",".",".",".","pfam00336","DNA_pol_viral_C","DNA polymerase (viral) C-terminal domain.",".",".",".",".","."]
["ENSRNOG00000017833",50,4.151333026,136,8.748939593,0.474495564,-1.075533495,{"v":1.53629e-06,"d":"1.54E-06"},{"v":2.29033e-06,"d":"2.29E-06"},"down","yes","Actn2","protein_coding","chr17:58142625-58210622:+","gi|157951643|ref|NP_150371.4|",4057,0,"alpha-actinin-2 [Mus musculus]","gi|281332156|ref|NM_001170325.1|",2557,0,"Rattus norvegicus actinin alpha 2 (Actn2), mRNA","Q9JI91",1567,0,"Alpha-actinin-2","SPAC15A10.08",247,{"v":1e-69,"d":"1.00E-69"},"COG5069","pfam00307","CH","Calponin homology (CH) domain. The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.","GO:0006936|muscle contraction;GO:0030035|microspike assembly;GO:0030036|actin cytoskeleton organization;GO:0042391|regulation of membrane potential;GO:0043267|negative regulation of potassium ion transport;GO:0043268|positive regulation of potassium ion transport;GO:0045214|sarcomere organization;GO:0045893|positive regulation of transcription, DNA-templated;GO:0048041|focal adhesion assembly;GO:0051695|actin filament uncapping;GO:0055001|muscle cell development;GO:0055013|cardiac muscle cell development;GO:0072659|protein localization to plasma membrane;GO:0086097|phospholipase C-activating angiotensin-activated signaling pathway;GO:1901017|negative regulation of potassium ion transmembrane transporter activity;GO:1901018|positive regulation of potassium ion transmembrane transporter activity;GO:2000009|negative regulation of protein localization to cell surface;GO:2001137|positive regulation of endocytic recycling;GO:2001259|positive regulation of cation channel activity;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005925|focal adhesion;GO:0030017|sarcomere;GO:0030018|Z disc;GO:0030054|cell junction;GO:0030175|filopodium;GO:0030864|cortical actin cytoskeleton;GO:0042995|cell projection;GO:0098839|postsynaptic density membrane;GO:0098978|glutamatergic synapse;GO:0099092|postsynaptic density, intracellular component;","GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0008092|cytoskeletal protein binding;GO:0019904|protein domain specific binding;GO:0030274|LIM domain binding;GO:0030374|nuclear receptor transcription coactivator activity;GO:0031432|titin binding;GO:0042802|identical protein binding;GO:0044325|ion channel binding;GO:0051015|actin filament binding;GO:0051373|FATZ binding;GO:0070080|titin Z domain binding;","K21073","ACTN2_3; actinin alpha 2/3"]
["ENSRNOG00000006575",19,1.57750655,74,4.760452426,0.331377443,-1.593452696,{"v":1.57207E-6,"d":"1.57E-06"},{"v":2.33984e-06,"d":"2.34E-06"},"down","yes","Ccdc96","protein_coding","chr14:74276960-74278888:-","gi|109499890|ref|XP_223518.4|",2172,0,"PREDICTED: coiled-coil domain-containing protein 96 [Rattus norvegicus]","gi|672028047|ref|XM_001063560.4|",1711,0,"PREDICTED: Rattus norvegicus coiled-coil domain containing 96 (Ccdc96), mRNA","Q9CR92",693,0,"Coiled-coil domain-containing protein 96",".",".",".",".","pfam13870","DUF4201","Domain of unknown function (DUF4201). This is a family of coiled-coil proteins from eukaryotes. The function is not known.","GO:0060271|cilium assembly;","GO:0005930|axoneme;GO:0036064|ciliary basal body;",".",".","."]
["ENSRNOG00000006025",27,2.241719834,91,5.854069875,0.382933563,-1.384833982,{"v":1.60152E-6,"d":"1.60E-06"},{"v":2.37869e-06,"d":"2.38E-06"},"down","yes","Lamb3","protein_coding","chr13:104833873-104875405:+","gi|281371337|ref|NP_001094311.1|",5742,0,"laminin subunit beta-3 precursor [Rattus norvegicus]","gi|281371336|ref|NM_001100841.1|",4078,0,"Rattus norvegicus laminin subunit beta 3 (Lamb3), mRNA","Q61087",2065,0,"Laminin subunit beta-3",".",".",".",".","pfam00055","Laminin_N","Laminin N-terminal (Domain VI).","GO:0008150|biological_process;GO:0009887|animal organ morphogenesis;GO:0009888|tissue development;GO:0016477|cell migration;GO:0034446|substrate adhesion-dependent cell spreading;GO:0035987|endodermal cell differentiation;GO:0050873|brown fat cell differentiation;GO:0070831|basement membrane assembly;","GO:0005575|cellular_component;GO:0005604|basement membrane;GO:0005610|laminin-5 complex;GO:0043256|laminin complex;","GO:0005201|extracellular matrix structural constituent;GO:0044877|protein-containing complex binding;","K06244","LAMB3; laminin, beta 3"]
["ENSRNOG00000067461",34,2.822906458,105,6.754696009,0.417917617,-1.25870952,{"v":1.68342E-6,"d":"1.68E-06"},{"v":2.49512e-06,"d":"2.50E-06"},"down","yes","Rps12l2","protein_coding","chr1:252597664-252598155:+","gi|823458574|ref|XP_002191710.2|",677,{"v":2E-87,"d":"2.00E-87"},"PREDICTED: 40S ribosomal protein S12 [Taeniopygia guttata]","gi|298911600|emb|FQ222422.1|",483,0,"Rattus norvegicus TL0ADA23YK16 mRNA sequence","P46405",259,{"v":7e-88,"d":"7.00E-88"},"40S ribosomal protein S12","SPCC962.04",151,{"v":1e-45,"d":"1.00E-45"},"COG1358","pfam01248","Ribosomal_L7Ae","Ribosomal protein L7Ae/L30e/S12e/Gadd45 family. This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118.",".",".",".",".","."]
["ENSRNOG00000018039",0,0.04151333,24,1.543930516,0.026888082,-5.216889345,{"v":1.76725e-06,"d":"1.77E-06"},{"v":2.61211e-06,"d":"2.61E-06"},"down","yes","Sncb","protein_coding","chr17:9846802-9855012:+","gi|970705124|ref|XP_015090439.1|",475,{"v":1E-53,"d":"1.00E-53"},"PREDICTED: beta-synuclein [Vicugna pacos]","gi|672081072|ref|XM_006253594.2|",1114,0,"PREDICTED: Rattus norvegicus synuclein, beta (Sncb), transcript variant X1, mRNA","P33567",181,{"v":3e-53,"d":"3.00E-53"},"Beta-synuclein",".",".",".",".","pfam01387","Synuclein","Synuclein. There are three types of synucleins in humans, these are called alpha, beta and gamma. Alpha synuclein has been found mutated in families with autosomal dominant Parkinson's disease. A peptide of alpha synuclein has also been found in amyloid plaques in Alzheimer's patients.","GO:0007268|chemical synaptic transmission;GO:0042417|dopamine metabolic process;GO:0043524|negative regulation of neuron apoptotic process;GO:0048488|synaptic vesicle endocytosis;GO:0050808|synapse organization;GO:1901214|regulation of neuron death;","GO:0005737|cytoplasm;GO:0016234|inclusion body;GO:0030426|growth cone;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0043679|axon terminus;GO:0045202|synapse;GO:0098793|presynapse;GO:0099523|presynaptic cytosol;","GO:0005509|calcium ion binding;GO:0043014|alpha-tubulin binding;GO:0046914|transition metal ion binding;GO:0048487|beta-tubulin binding;GO:1903136|cuprous ion binding;","K24201","SNCB; beta-synuclein"]
["ENSRNOG00000005291",46,3.819226384,128,8.234296088,0.463819414,-1.108364888,{"v":1.77026E-6,"d":"1.77E-06"},{"v":2.61534E-6,"d":"2.62E-06"},"down","yes","Slc38a1","protein_coding","chr7:127738226-127802218:-","gi|20301960|ref|NP_620187.1|",2287,0,"sodium-coupled neutral amino acid transporter 1 [Rattus norvegicus]","gi|20301959|ref|NM_138832.1|",2110,0,"Rattus norvegicus solute carrier family 38, member 1 (Slc38a1), mRNA","Q9JM15",885,0,"Sodium-coupled neutral amino acid transporter 1","YEL064c",94,{"v":2E-19,"d":"2.00E-19"},"COG0814","pfam01490","Aa_trans","Transmembrane amino acid transporter protein. This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.","GO:0003333|amino acid transmembrane transport;GO:0006814|sodium ion transport;GO:0006868|glutamine transport;GO:0007565|female pregnancy;GO:0015804|neutral amino acid transport;GO:0015807|L-amino acid transport;GO:1902475|L-alpha-amino acid transmembrane transport;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0016323|basolateral plasma membrane;GO:0030424|axon;GO:0043025|neuronal cell body;GO:0098591|external side of apical plasma membrane;","GO:0005295|neutral amino acid:sodium symporter activity;GO:0015171|amino acid transmembrane transporter activity;GO:0015179|L-amino acid transmembrane transporter activity;GO:0015186|L-glutamine transmembrane transporter activity;","K14990","SLC38A1, SNAT1, GLNT; solute carrier family 38 (sodium-coupled neutral amino acid transporter), member 1"]
["ENSRNOG00000062859",5,0.415133303,39,2.508887089,0.16546512,-2.595400968,{"v":1.81557e-06,"d":"1.82E-06"},{"v":2.67796e-06,"d":"2.68E-06"},"down","yes","RGD1565622","protein_coding","chr5:158198851-158228089:-","gi|672020249|ref|XP_008774368.1|",3671,0,"PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 260-like isoform X1, partial [Rattus norvegicus]","gi|672020248|ref|XM_008776146.1|",2205,0,"PREDICTED: Rattus norvegicus RGD1565622 (RGD1565622), transcript variant X1, partial mRNA","Q8TAQ5",550,0,"Zinc finger protein 420",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000069775",5,0.415133303,39,2.508887089,0.16546512,-2.595400968,{"v":1.81557e-06,"d":"1.82E-06"},{"v":2.67796e-06,"d":"2.68E-06"},"down","yes","ENSRNOG00000069775","lncRNA","chr2:39508461-39526936:-",".",".",".",".","gi|672041438|ref|XR_590885.1|",1423,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102549347 (LOC102549347), transcript variant X4, ncRNA",".",".",".",".",".",".",".",".","pfam04388","Hamartin","Hamartin protein. This family includes the hamartin protein which is thought to function as a tumor suppressor. The hamartin protein interacts with the tuberin protein pfam03542. Tuberous sclerosis complex (TSC) is an autosomal dominant disorder and is characterized by the presence of hamartomas in many organs, such as brain, skin, heart, lung, and kidney. It is caused by mutation either TSC1 or TSC2 tumor suppressor gene. TSC1 encodes a protein, hamartin, containing two coiled-coil regions, which have been shown to mediate binding to tuberin. The TSC2 gene codes for tuberin pfam03542. These two proteins function within the same pathway(s) regulating cell cycle, cell growth, adhesion, and vesicular trafficking.",".",".",".",".","."]
["ENSRNOG00000014874",14,1.162373247,62,3.988487167,0.291432114,-1.778768232,{"v":2.02006e-06,"d":"2.02E-06"},{"v":2.96453e-06,"d":"2.96E-06"},"down","yes","Zfyve28","protein_coding","chr14:76468424-76554039:+","gi|564384371|ref|XP_006251318.1|",4789,0,"PREDICTED: lateral signaling target protein 2 homolog isoform X1 [Rattus norvegicus]","gi|672076706|ref|XM_006251256.2|",3997,0,"PREDICTED: Rattus norvegicus zinc finger, FYVE domain containing 28 (Zfyve28), transcript variant X1, mRNA","Q6ZPK7",1746,0,"Lateral signaling target protein 2 homolog",".",".",".",".","pfam01363","FYVE","FYVE zinc finger. The FYVE zinc finger is named after four proteins that it has been found in: Fab1, YOTB/ZK632.12, Vac1, and EEA1. The FYVE finger has been shown to bind two Zn++ ions. The FYVE finger has eight potential zinc coordinating cysteine positions. Many members of this family also include two histidines in a motif R+HHC+XCG, where + represents a charged residue and X any residue. We have included members which do not conserve these histidine residues but are clearly related.","GO:0007175|negative regulation of epidermal growth factor-activated receptor activity;GO:0042059|negative regulation of epidermal growth factor receptor signaling pathway;","GO:0005829|cytosol;GO:0031901|early endosome membrane;","GO:0032266|phosphatidylinositol-3-phosphate binding;GO:0046872|metal ion binding;","K24780","ZFYVE28, LST2; lateral signaling target protein 2"]
["ENSRNOG00000010205",8,0.664213284,47,3.023530595,0.21968135,-2.186515695,{"v":2.15521E-6,"d":"2.16E-06"},{"v":3.15202e-06,"d":"3.15E-06"},"down","yes","Mturn","protein_coding","chr4:83807579-83824950:+","gi|56090335|ref|NP_001007646.1|",653,{"v":1E-79,"d":"1.00E-79"},"maturin [Rattus norvegicus]","gi|56090334|ref|NM_001007645.1|",1578,0,"Rattus norvegicus maturin, neural progenitor differentiation regulator homolog (Xenopus) (Mturn), mRNA","Q5XI20",256,{"v":3e-81,"d":"3.00E-81"},"Maturin",".",".",".",".","pfam15167","DUF4581","Domain of unknown function (DUF4581). This family of proteins is found in eukaryotes. Proteins in this family are typically 131 amino acids in length.","GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0045654|positive regulation of megakaryocyte differentiation;GO:0046330|positive regulation of JNK cascade;GO:0070374|positive regulation of ERK1 and ERK2 cascade;","GO:0005737|cytoplasm;",".",".","."]
["ENSRNOG00000006957",1,0.083026661,25,1.608260955,0.051625117,-4.275783034,{"v":2.53683E-6,"d":"2.54E-06"},{"v":3.67401e-06,"d":"3.67E-06"},"down","yes","Gria4","protein_coding","chr8:1562119-2034979:-","gi|940757567|ref|XP_006098893.2|",4726,0,"PREDICTED: glutamate receptor 4 isoform X1 [Myotis lucifugus]","gi|164419760|ref|NM_017263.2|",4124,0,"Rattus norvegicus glutamate ionotropic receptor AMPA type subunit 4 (Gria4), transcript variant 1, mRNA","Q9Z2W8",1813,0,"Glutamate receptor 4","YPO1846",54.3,7e-07,"COG0834","pfam00060","Lig_chan","Ligand-gated ion channel. This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.","GO:0007268|chemical synaptic transmission;GO:0034220|ion transmembrane transport;GO:0035235|ionotropic glutamate receptor signaling pathway;GO:0050803|regulation of synapse structure or activity;GO:0050804|modulation of chemical synaptic transmission;GO:0051968|positive regulation of synaptic transmission, glutamatergic;GO:0060078|regulation of postsynaptic membrane potential;GO:0060992|response to fungicide;","GO:0005886|plasma membrane;GO:0008328|ionotropic glutamate receptor complex;GO:0014069|postsynaptic density;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0032281|AMPA glutamate receptor complex;GO:0032983|kainate selective glutamate receptor complex;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0043197|dendritic spine;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0098978|glutamatergic synapse;GO:0099061|integral component of postsynaptic density membrane;","GO:0004970|ionotropic glutamate receptor activity;GO:0004971|AMPA glutamate receptor activity;GO:0005515|protein binding;GO:0015276|ligand-gated ion channel activity;GO:0038023|signaling receptor activity;GO:0042802|identical protein binding;GO:1904315|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K05200","GRIA4; glutamate receptor 4"]
["ENSRNOG00000047002",1,0.083026661,25,1.608260955,0.051625117,-4.275783034,{"v":2.53683E-6,"d":"2.54E-06"},{"v":3.67401e-06,"d":"3.67E-06"},"down","yes","Fstl5","protein_coding","chr2:160856291-161526589:+","gi|403225027|ref|NP_001258124.1|",4560,0,"follistatin-related protein 5 precursor [Rattus norvegicus]","gi|403225026|ref|NM_001271195.1|",5084,0,"Rattus norvegicus follistatin-like 5 (Fstl5), mRNA","Q8BFR2",1718,0,"Follistatin-related protein 5",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0007275|multicellular organism development;GO:0030154|cell differentiation;","GO:0005576|extracellular region;","GO:0005509|calcium ion binding;","K23915","FSTL5; follistatin-related protein 5"]
["ENSRNOG00000026344",16,1.328426568,66,4.24580892,0.312879499,-1.676320963,{"v":2.56759e-06,"d":"2.57E-06"},{"v":3.71603e-06,"d":"3.72E-06"},"down","yes","Togaram2","protein_coding","chr6:23771052-23828499:-","gi|672020443|ref|XP_002726744.3|",5366,0,"PREDICTED: protein FAM179A [Rattus norvegicus]","gi|672020442|ref|XM_002726698.4|",3232,0,"PREDICTED: Rattus norvegicus family with sequence similarity 179, member A (Fam179a), mRNA",".",".",".",".",".",".",".",".","pfam12348","CLASP_N","CLASP N terminal. This region is found at the N terminal of CLIP-associated proteins (CLASPs).  CLASPs are widely conserved microtubule plus-end-tracking proteins that regulate the stability of dynamic microtubules. In yeast, Drosophila, and Xenopus, a single CLASP orthologue is present. In mammals, a second paralogue (CLASP2) exists which has some functional overlap with CLASP1.","GO:0000226|microtubule cytoskeleton organization;GO:0090307|mitotic spindle assembly;","GO:0005815|microtubule organizing center;GO:0005876|spindle microtubule;GO:0005881|cytoplasmic microtubule;GO:0005929|cilium;GO:0072686|mitotic spindle;","GO:0008017|microtubule binding;","K24886","TOGARAM; TOG array regulator of axonemal microtubules protein"]
["ENSRNOG00000002004",3,0.249079982,32,2.058574022,0.120996369,-3.046964343,{"v":2.68414e-06,"d":"2.68E-06"},{"v":3.87332e-06,"d":"3.87E-06"},"down","yes","Prdm8","protein_coding","chr14:11404407-11410993:-","gi|672027688|ref|XP_008762818.1|",2506,0,"PREDICTED: PR domain zinc finger protein 8 isoform X2 [Rattus norvegicus]","gi|672075930|ref|XM_008770082.1|",3075,0,"PREDICTED: Rattus norvegicus PR domain containing 8 (Prdm8), transcript variant X4, mRNA","Q9NQV8",867,0,"PR domain zinc finger protein 8",".",".",".",".","pfam00096","zf-C2H2","Zinc finger, C2H2 type. The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.","GO:0006355|regulation of transcription, DNA-templated;GO:0008150|biological_process;GO:0014003|oligodendrocyte development;GO:0016571|histone methylation;GO:0021540|corpus callosum morphogenesis;GO:0021952|central nervous system projection neuron axonogenesis;GO:0021957|corticospinal tract morphogenesis;GO:0022008|neurogenesis;GO:0045892|negative regulation of transcription, DNA-templated;GO:0051567|histone H3-K9 methylation;","GO:0005575|cellular_component;GO:0005634|nucleus;","GO:0003674|molecular_function;GO:0003682|chromatin binding;GO:0003714|transcription corepressor activity;GO:0042054|histone methyltransferase activity;GO:0046974|histone methyltransferase activity (H3-K9 specific);","K20797","PRDM8; PR domain zinc finger protein 8 [EC:2.1.1.-]"]
["ENSRNOG00000045741",50,4.151333026,134,8.620278717,0.481577587,-1.054159845,{"v":2.6854e-06,"d":"2.69E-06"},{"v":3.87426e-06,"d":"3.87E-06"},"down","yes","AABR07071891.2","protein_coding","chr1:61123043-61148954:+","gi|672012885|ref|XP_008772576.1|",221,{"v":4e-20,"d":"4.00E-20"},"PREDICTED: zinc finger protein 525-like isoform X2 [Rattus norvegicus]","gi|672034827|ref|XM_008758857.1|",117,{"v":5E-53,"d":"5.00E-53"},"PREDICTED: Rattus norvegicus zinc finger protein 679-like (LOC103691005), transcript variant X3, mRNA","Q95K52",75.9,{"v":6e-16,"d":"6.00E-16"},"Zinc finger protein 283",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000063993",22,1.826586532,79,5.082104617,0.359415374,-1.476275973,{"v":2.7205E-6,"d":"2.72E-06"},{"v":3.92312e-06,"d":"3.92E-06"},"down","yes","ENSRNOG00000063993","lncRNA","chr16:36104701-36157250:-","gi|355779658|gb|EHH64134.1|",465,{"v":7e-43,"d":"7.00E-43"},"Histone acetyltransferase MYST3 [Macaca fascicularis]","gi|308044617|gb|AC240962.4|",3458,0,"Rattus norvegicus Y Chr BAC RNECO-87N03 (Amplicon Express Rat SHR-Akr (EcoR1 Digest) BAC library) complete sequence","B5DFC9",95.1,{"v":2e-27,"d":"2.00E-27"},"Nidogen-2",".",".",".",".","pfam06119","NIDO","Nidogen-like. This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function.",".",".",".",".","."]
["ENSRNOG00000067016",48,3.985279705,130,8.362956964,0.476539545,-1.069332156,{"v":2.90871e-06,"d":"2.91E-06"},{"v":4.18234E-6,"d":"4.18E-06"},"down","yes","ENSRNOG00000067016","lncRNA","chr17:4937597-4942625:-","gi|149039763|gb|EDL93879.1|",288,{"v":1E-27,"d":"1.00E-27"},"rCG24170, isoform CRA_a [Rattus norvegicus]","gi|672080997|ref|XR_360701.2|",312,{"v":2E-160,"d":"2.00E-160"},"PREDICTED: Rattus norvegicus uncharacterized LOC102547829 (LOC102547829), transcript variant X2, ncRNA",".",".",".",".",".",".",".",".","pfam03708","Avian_gp85","Avian retrovirus envelope protein, gp85. Family of a vain specific viral glycoproteins that forms a receptor-binding gp85 polypeptide that is linked through disulfide to a membrane-spanning gp37 spike. Gp85 confers a high degree of subgroup specificity for interaction with distinct cell receptors.",".",".",".",".","."]
["ENSRNOG00000063185",54,4.483439668,141,9.070591784,0.494283039,-1.016590694,{"v":2.96405E-6,"d":"2.96E-06"},{"v":4.25802e-06,"d":"4.26E-06"},"down","yes","ENSRNOG00000063185","protein_coding","chr17:3063877-3091699:-","gi|672029680|ref|XP_008772142.1|",2720,0,"PREDICTED: zinc finger protein 431-like isoform X3 [Rattus norvegicus]","gi|672029634|ref|XM_008773616.1|",1906,0,"PREDICTED: Rattus norvegicus zinc finger protein 845-like (LOC102556556), mRNA","Q8TF20",549,0,"Zinc finger protein 721","SPAC144.09c",119,{"v":1E-27,"d":"1.00E-27"},"COG5048","pfam13465","zf-H2C2_2","Zinc-finger double domain.",".",".",".",".","."]
["ENSRNOG00000062931",55,4.566466329,142,9.134922222,0.499891101,-1.00031425,{"v":3.69599E-6,"d":"3.70E-06"},{"v":5.24701e-06,"d":"5.25E-06"},"down","yes","ENSRNOG00000062931","protein_coding","chr7:7602683-7651352:+","gi|251823941|ref|NP_001156535.1|",1996,0,"zinc finger protein 878 [Rattus norvegicus]","gi|672057882|ref|XR_355238.2|",1127,0,"PREDICTED: Rattus norvegicus zinc finger protein 709-like 1 (Zfp709l1), transcript variant X1, misc_RNA","E9QAG8",495,{"v":7e-161,"d":"7.00E-161"},"Zinc finger protein 431",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000055001",52,4.317386347,136,8.748939593,0.493475387,-1.018949967,{"v":4.25629e-06,"d":"4.26E-06"},{"v":6.01706e-06,"d":"6.02E-06"},"down","yes","AABR07005004.3","snoRNA","chr1:163540664-163540793:+",".",".",".",".","gi|908662943|tpe|LN872384.1|",110,{"v":2e-49,"d":"2.00E-49"},"TPA: Mus musculus SNORA3 (ACA3) gene for small nucleolar RNA SNORA3 (ACA3)",".",".",".",".",".",".",".",".","pfam10951","DUF2776","Protein of unknown function (DUF2776). This bacterial family of proteins has no known function.",".",".",".",".","."]
["ENSRNOG00000029798",11,0.913293266,53,3.409513224,0.267866175,-1.90041568,{"v":4.31585e-06,"d":"4.32E-06"},{"v":6.09587E-6,"d":"6.10E-06"},"down","yes","Lrrc4c","protein_coding","chr3:83483851-83687774:+","gi|157820475|ref|NP_001101223.1|",3330,0,"leucine-rich repeat-containing protein 4C precursor [Rattus norvegicus]","gi|45752212|emb|BX813336.4|",3072,0,"Mouse DNA sequence from clone RP23-207B5 on chromosome 2, complete sequence","Q8C031",1284,0,"Leucine-rich repeat-containing protein 4C","SPy1798",75.5,{"v":3e-12,"d":"3.00E-12"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0008150|biological_process;GO:0050770|regulation of axonogenesis;GO:0050804|modulation of chemical synaptic transmission;GO:0099560|synaptic membrane adhesion;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098978|glutamatergic synapse;GO:0099061|integral component of postsynaptic density membrane;","GO:0003674|molecular_function;GO:0050839|cell adhesion molecule binding;GO:0098632|cell-cell adhesion mediator activity;","K07523","LRRC4C, NGL1; netrin-G1 ligand"]
["ENSRNOG00000064088",1,0.083026661,24,1.543930516,0.053776164,-4.216889345,{"v":4.36451e-06,"d":"4.36E-06"},{"v":6.16097e-06,"d":"6.16E-06"},"down","yes","ENSRNOG00000064088","protein_coding","chr9:106027363-106052080:-","gi|672033317|ref|XP_008756392.1|",2641,0,"PREDICTED: sperm motility kinase W-like [Rattus norvegicus]","gi|672033318|ref|XM_008758171.1|",5117,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102555328 (LOC102555328), transcript variant X2, mRNA","Q8C0V7",559,{"v":1E-175,"d":"1.00E-175"},"Putative sperm motility kinase W",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.",".",".",".",".","."]
["ENSRNOG00000064025",33,2.739879797,100,6.433043818,0.425907218,-1.231388914,{"v":4.36904e-06,"d":"4.37E-06"},{"v":6.16555e-06,"d":"6.17E-06"},"down","yes","ENSRNOG00000064025","protein_coding","chr17:41574520-41575555:-","gi|586484892|ref|XP_006872940.1|",420,{"v":2e-47,"d":"2.00E-47"},"PREDICTED: histone H4-like [Chrysochloris asiatica]","gi|672030058|ref|XM_003752983.3|",466,0,"PREDICTED: Rattus norvegicus similar to germinal histone H4 gene (LOC680097), mRNA","Q28DR4",162,{"v":9e-48,"d":"9.00E-48"},"Histone H4",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.",".",".",".",".","."]
["ENSRNOG00000020879",14,1.162373247,60,3.859826291,0.301146518,-1.731462517,{"v":4.49045e-06,"d":"4.49E-06"},{"v":6.32849e-06,"d":"6.33E-06"},"down","yes","Nags","protein_coding","chr10:87098330-87102465:+","gi|564374250|ref|XP_006247390.1|",2409,0,"PREDICTED: N-acetylglutamate synthase, mitochondrial isoform X1 [Rattus norvegicus]","gi|157817439|ref|NM_001107053.1|",2111,0,"Rattus norvegicus N-acetylglutamate synthase (Nags), mRNA","Q8R4H7",883,0,"N-acetylglutamate synthase, mitochondrial","YER069w_1",122,{"v":2e-28,"d":"2.00E-28"},"COG0548","pfam04768","DUF619","Protein of unknown function (DUF619). This region of unknown function is found at the C-terminus of Neurospora crassa acetylglutamate synthase (amino-acid acetyltransferase, EC: 2.3.1.1). It is also found C-terminal to the amino acid kinase region (pfam00696) in some fungal acetylglutamate kinase enzymes.","GO:0006526|arginine biosynthetic process;GO:0006536|glutamate metabolic process;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005739|mitochondrion;GO:0005759|mitochondrial matrix;","GO:0004042|acetyl-CoA:L-glutamate N-acetyltransferase activity;GO:0034618|arginine binding;","K11067","NAGS; N-acetylglutamate synthase [EC:2.3.1.1]"]
["ENSRNOG00000014081",5,0.415133303,37,2.380226213,0.17440918,-2.519452115,{"v":4.81503E-6,"d":"4.82E-06"},{"v":6.75912e-06,"d":"6.76E-06"},"down","yes","Nmur2","protein_coding","chr10:40166226-40182078:-","gi|149052674|gb|EDM04491.1|",2161,0,"neuromedin U receptor 2 [Rattus norvegicus]","gi|399154158|ref|NM_022275.3|",3302,0,"Rattus norvegicus neuromedin U receptor 2 (Nmur2), mRNA","Q9ESQ4",752,0,"Neuromedin-U receptor 2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0002023|reduction of food intake in response to dietary excess;GO:0006816|calcium ion transport;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007218|neuropeptide signaling pathway;GO:0007417|central nervous system development;GO:0007625|grooming behavior;GO:0015698|inorganic anion transport;GO:0043006|activation of phospholipase A2 activity by calcium-mediated signaling;GO:0048016|inositol phosphate-mediated signaling;GO:0048265|response to pain;GO:0050482|arachidonic acid secretion;GO:0051930|regulation of sensory perception of pain;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0001607|neuromedin U receptor activity;GO:0004930|G protein-coupled receptor activity;GO:0005229|intracellular calcium activated chloride channel activity;GO:0005525|GTP binding;GO:0008188|neuropeptide receptor activity;GO:0042924|neuromedin U binding;","K05053","NMUR2; neuromedin U receptor 2"]
["ENSRNOG00000060021",5,0.415133303,37,2.380226213,0.17440918,-2.519452115,{"v":4.81503E-6,"d":"4.82E-06"},{"v":6.75912e-06,"d":"6.76E-06"},"down","yes","Txlnb","protein_coding","chr1:12404859-12449975:+","gi|209529675|ref|NP_001129331.1|",2980,0,"beta-taxilin [Rattus norvegicus]","gi|209529674|ref|NM_001135859.1|",4044,0,"Rattus norvegicus taxilin beta (Txlnb), mRNA","Q8VBT1",927,0,"Beta-taxilin",".",".",".",".","pfam09728","Taxilin","Myosin-like coiled-coil protein. Taxilin contains an extraordinarily long coiled-coil domain in its C-terminal half and is ubiquitously expressed. It is a novel binding partner of several syntaxin family members and is possibly involved in Ca2+-dependent exocytosis in neuroendocrine cells. Gamma-taxilin, described as leucine zipper protein Factor Inhibiting ATF4-mediated Transcription (FIAT), localizes to the nucleus in osteoblasts and dimerises with ATF4 to form inactive dimers, thus inhibiting ATF4-mediated transcription.",".","GO:0005737|cytoplasm;","GO:0019905|syntaxin binding;",".","."]
["ENSRNOG00000060816",16,1.328426568,64,4.117148044,0.322656983,-1.631926844,{"v":5.54429e-06,"d":"5.54E-06"},{"v":7.7218e-06,"d":"7.72E-06"},"down","yes","Gm22988","snoRNA","chr10:54387185-54387327:-",".",".",".",".","gi|755540011|ref|XM_006534485.2|",109,{"v":8e-49,"d":"8.00E-49"},"PREDICTED: Mus musculus Sec24 related gene family, member A (S. cerevisiae) (Sec24a), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam10070","DUF2309","Uncharacterized protein conserved in bacteria (DUF2309). Members of this family of hypothetical bacterial proteins have no known function.",".",".",".",".","."]
["ENSRNOG00000026112",35,2.905933118,103,6.626035133,0.43856289,-1.189144354,{"v":5.77261e-06,"d":"5.77E-06"},{"v":8.02929e-06,"d":"8.03E-06"},"down","yes","Tmem202","protein_coding","chr8:59910824-59916609:-","gi|157820301|ref|NP_001103106.1|",1415,0,"transmembrane protein 202 [Rattus norvegicus]","gi|157820300|ref|NM_001109636.1|",1282,0,"Rattus norvegicus transmembrane protein 202 (Tmem202), mRNA","Q80W35",391,{"v":2e-133,"d":"2.00E-133"},"Transmembrane protein 202",".",".",".",".","pfam00822","PMP22_Claudin","PMP-22/EMP/MP20/Claudin family.",".","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000066818",2,0.166053321,27,1.736921831,0.095602069,-3.386814346,{"v":6.23768e-06,"d":"6.24E-06"},{"v":8.6386e-06,"d":"8.64E-06"},"down","yes","ENSRNOG00000066818","lncRNA","chr1:39289190-39330338:+","gi|672072106|ref|XP_006248795.2|",361,{"v":1E-73,"d":"1.00E-73"},"PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC302022 isoform X1 [Rattus norvegicus]","gi|672033277|ref|XR_349384.2|",1173,0,"PREDICTED: Rattus norvegicus similar to nidogen 2 (LOC367597), transcript variant X5, misc_RNA","B5DFC9",115,{"v":6e-66,"d":"6.00E-66"},"Nidogen-2",".",".",".",".","pfam06119","NIDO","Nidogen-like. This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function.",".",".",".",".","."]
["ENSRNOG00000067311",18,1.494479889,68,4.374469797,0.341636806,-1.549464684,{"v":6.4753e-06,"d":"6.48E-06"},{"v":8.95023e-06,"d":"8.95E-06"},"down","yes","ENSRNOG00000067311","lncRNA","chr2:148725364-148727966:+",".",".",".",".","gi|672015838|ref|XR_344406.2|",1001,0,"PREDICTED: Rattus norvegicus spindlin-1-like (LOC102549890), transcript variant X1, misc_RNA",".",".",".",".",".",".",".",".","pfam04146","YTH","YT521-B-like domain. A protein of the YTH family has been shown to selectively remove transcripts of meiosis-specific genes expressed in mitotic cells. It has been speculated that in higher eukaryotic YTH-family members may be involved in similar mechanisms to suppress gene regulation during gametogenesis or general silencing. The rat protein YT521-B is a tyrosine-phosphorylated nuclear protein, that interacts with the nuclear transcriptosomal component scaffold attachment factor B, and the 68-kDa Src substrate associated during mitosis, Sam68. In vivo splicing assays demonstrated that YT521-B modulates alternative splice site selection in a concentration-dependent manner. The YTH domain has been identified as part of the PUA superfamily.",".",".",".",".","."]
["ENSRNOG00000070099",6,0.498159963,39,2.508887089,0.198558144,-2.332366562,{"v":7.14754E-6,"d":"7.15E-06"},{"v":9.82208e-06,"d":"9.82E-06"},"down","yes","Crb3","protein_coding","chr9:1896623-1903859:+","gi|564366823|ref|XP_006244365.1|",519,{"v":2e-62,"d":"2.00E-62"},"PREDICTED: protein crumbs homolog 3 isoform X1 [Rattus norvegicus]","gi|298889082|emb|FQ223867.1|",955,0,"Rattus norvegicus TL0ACA84YK03 mRNA sequence","Q8QZT4",128,{"v":1e-34,"d":"1.00E-34"},"Protein crumbs homolog 3",".",".",".",".","pfam14610","DUF4448","Protein of unknown function (DUF4448). This is a family of predicted membrane glycoproteins from fungi. However there appears, visually, to be some similarity with the family of GPI-anchored fungal proteins, pfam10342.",".",".",".",".","."]
["ENSRNOG00000025160",37,3.071986439,106,6.819026448,0.450502203,-1.150393933,{"v":7.45748e-06,"d":"7.46E-06"},{"v":1.02216e-05,"d":"1.02E-05"},"down","yes","Tlcd4","protein_coding","chr2:209289732-209341353:-","gi|209529652|ref|NP_001129351.1|",1374,0,"transmembrane protein 56 [Rattus norvegicus]","gi|672044036|ref|XM_006233246.2|",1282,0,"PREDICTED: Rattus norvegicus transmembrane protein 56 (Tmem56), transcript variant X3, mRNA","Q8CGF5",474,{"v":1E-165,"d":"1.00E-165"},"Transmembrane protein 56",".",".",".",".","pfam03798","TRAM_LAG1_CLN8","TLC domain.","GO:0008150|biological_process;GO:0055088|lipid homeostasis;","GO:0005575|cellular_component;GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;",".","."]
["ENSRNOG00000017159",1,0.083026661,23,1.479600078,0.056114258,-4.1554888,{"v":7.5191e-06,"d":"7.52E-06"},{"v":1.02906e-05,"d":"1.03E-05"},"down","yes","Dsc3","protein_coding","chr18:11377347-11413797:-","gi|157823393|ref|NP_001100872.1|",4809,0,"desmocollin-3 [Rattus norvegicus]","gi|133778946|ref|NM_007882.3|",3235,0,"Mus musculus desmocollin 3 (Dsc3), transcript variant 1, mRNA","P55850",1729,0,"Desmocollin-3",".",".",".",".","pfam01049","Cadherin_C","Cadherin cytoplasmic region. Cadherins are vital in cell-cell adhesion during tissue differentiation. Cadherins are linked to the cytoskeleton by catenins. Catenins bind to the cytoplasmic tail of the cadherin. Cadherins cluster to form foci of homophilic binding units. A key determinant to the strength of the binding that it is mediated by cadherins is the juxtamembrane region of the cadherin. This region induces clustering and also binds to the protein p120ctn.","GO:0001701|in utero embryonic development;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0050821|protein stabilization;GO:0098609|cell-cell adhesion;","GO:0005576|extracellular region;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0016021|integral component of membrane;GO:0030054|cell junction;GO:0030057|desmosome;","GO:0005509|calcium ion binding;GO:0045295|gamma-catenin binding;","K07602","DSC3; desmocollin 3"]
["ENSRNOG00000047368",1,0.083026661,23,1.479600078,0.056114258,-4.1554888,{"v":7.5191e-06,"d":"7.52E-06"},{"v":1.02906e-05,"d":"1.03E-05"},"down","yes","Acer1","protein_coding","chr9:1793139-1824434:-","gi|157822473|ref|NP_001100345.1|",1454,0,"alkaline ceramidase 1 [Rattus norvegicus]","gi|157822472|ref|NM_001106875.1|",2328,0,"Rattus norvegicus alkaline ceramidase 1 (Acer1), mRNA","Q8R4X1",524,{"v":4e-180,"d":"4.00E-180"},"Alkaline ceramidase 1",".",".",".",".","pfam05875","Ceramidase","Ceramidase. This family consists of several ceramidases. Ceramidases are enzymes involved in regulating cellular levels of ceramides, sphingoid bases, and their phosphates, EC:3.5.1.23.","GO:0006665|sphingolipid metabolic process;GO:0008544|epidermis development;GO:0010446|response to alkaline pH;GO:0019216|regulation of lipid metabolic process;GO:0030148|sphingolipid biosynthetic process;GO:0030154|cell differentiation;GO:0030216|keratinocyte differentiation;GO:0033561|regulation of water loss via skin;GO:0046512|sphingosine biosynthetic process;GO:0046514|ceramide catabolic process;GO:0048733|sebaceous gland development;GO:0071277|cellular response to calcium ion;","GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;","GO:0017040|N-acylsphingosine amidohydrolase activity;GO:0071633|dihydroceramidase activity;GO:0102121|ceramidase activity;","K01441","ACER1_2, ASAH3; alkaline ceramidase [EC:3.5.1.23]"]
["ENSRNOG00000069840",1,0.083026661,23,1.479600078,0.056114258,-4.1554888,{"v":7.5191e-06,"d":"7.52E-06"},{"v":1.02906e-05,"d":"1.03E-05"},"down","yes","Pcdh11x","protein_coding","chrX:86058394-86747036:+","gi|403420604|ref|NP_001258157.1|",6915,0,"protocadherin-11 X-linked precursor [Rattus norvegicus]","gi|672088065|ref|XM_008773375.1|",4385,0,"PREDICTED: Rattus norvegicus protocadherin 11 X-linked (Pcdh11x), transcript variant X1, mRNA","Q6X862",2235,0,"Protocadherin-11 X-linked",".",".",".",".","pfam08374","Protocadherin","Protocadherin. The structure of protocadherins is similar to that of classic cadherins (pfam00028), but particularly on the cytoplasmic domains they also have some unique features. They are expressed in a variety of organisms and are found in high concentrations in the brain where they seem to be localized mainly at cell-cell contact sites. Their expression seems to be developmentally regulated.",".",".",".",".","."]
["ENSRNOG00000015403",3,0.249079982,30,1.929913146,0.129062793,-2.953854939,{"v":7.55703e-06,"d":"7.56E-06"},{"v":1.03293E-5,"d":"1.03E-05"},"down","yes","Cd52","protein_coding","chr5:146319969-146321348:-","gi|149024204|gb|EDL80701.1|",210,{"v":1e-19,"d":"1.00E-19"},"CD52 antigen [Rattus norvegicus]","gi|158937237|ref|NM_013706.2|",141,{"v":3e-66,"d":"3.00E-66"},"Mus musculus CD52 antigen (Cd52), mRNA","Q63064",82.8,{"v":5e-20,"d":"5.00E-20"},"CAMPATH-1 antigen",".",".",".",".","pfam15116","CD52","CAMPATH-1 antigen.","GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0009617|response to bacterium;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0031225|anchored component of membrane;GO:0097225|sperm midpiece;",".","K06488","CD52; CDW52 antigen"]
["ENSRNOG00000064638",45,3.736199724,121,7.78398302,0.479985595,-1.058936985,{"v":7.58597e-06,"d":"7.59E-06"},{"v":1.03644E-5,"d":"1.04E-05"},"down","yes","Hdhd3","protein_coding","chr5:75946013-75955266:-","gi|157824168|ref|NP_001102981.1|",1223,{"v":3e-150,"d":"3.00E-150"},"haloacid dehalogenase-like hydrolase domain-containing protein 3 [Rattus norvegicus]","gi|154354993|ref|NM_022261.2|",1330,0,"Rattus norvegicus B-box and SPRY domain containing (Bspry), mRNA","Q9CYW4",436,{"v":1e-137,"d":"1.00E-137"},"Haloacid dehalogenase-like hydrolase domain-containing protein 3","alr4095",116,{"v":3e-27,"d":"3.00E-27"},"COG1011","pfam13419","HAD_2","Haloacid dehalogenase-like hydrolase.",".",".",".",".","."]
["ENSRNOG00000009022",22,1.826586532,76,4.889113302,0.373602823,-1.420422739,{"v":7.82486e-06,"d":"7.82E-06"},{"v":1.06657E-5,"d":"1.07E-05"},"down","yes","Rtkn","protein_coding","chr4:115640774-115657952:+","gi|148666652|gb|EDK99068.1|",2840,0,"rhotekin, isoform CRA_b, partial [Mus musculus]","gi|34576548|ref|NM_184046.1|",2567,0,"Rattus norvegicus rhotekin (Rtkn), mRNA","Q6V7V2",1065,0,"Rhotekin",".",".",".",".","pfam08174","Anillin","Cell division protein anillin. Anillin is a protein involved in septin organisation during cell division.  It is an actin binding protein that is localized to the cleavage furrow, and it maintains the localisation of active myosin, which ensures the spatial control of concerted contraction during cytokinesis.","GO:0000281|mitotic cytokinesis;GO:0000915|actomyosin contractile ring assembly;GO:0006915|apoptotic process;GO:0007165|signal transduction;GO:0007266|Rho protein signal transduction;GO:0031106|septin ring organization;GO:0032185|septin cytoskeleton organization;GO:0042981|regulation of apoptotic process;GO:0043086|negative regulation of catalytic activity;","GO:0005826|actomyosin contractile ring;","GO:0005095|GTPase inhibitor activity;GO:0005525|GTP binding;GO:0031267|small GTPase binding;","K24024","RTKN; rhotekin"]
["ENSRNOG00000011445",22,1.826586532,76,4.889113302,0.373602823,-1.420422739,{"v":7.82486e-06,"d":"7.82E-06"},{"v":1.06657E-5,"d":"1.07E-05"},"down","yes","Nkain1","protein_coding","chr5:142747505-142791863:+","gi|133777687|gb|AAI16393.1|",1019,{"v":3E-131,"d":"3.00E-131"},"Nkain1 protein, partial [Mus musculus]","gi|672019956|ref|XM_008776102.1|",1588,0,"PREDICTED: Rattus norvegicus Na+/K+ transporting ATPase interacting 1 (Nkain1), transcript variant X1, mRNA","Q9D035",246,{"v":5e-114,"d":"5.00E-114"},"Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1",".",".",".",".","pfam05640","NKAIN","Na,K-Atpase Interacting protein. NKAIN (Na,K-Atpase INteracting) proteins are a family of evolutionary conserved transmembrane proteins that localize to neurons, that are critical for neuronal function, and that interact with the beta subunits, beta1 in vertebrates and beta in Drosophila, of Na,K-ATPase. NKAINs have highly conserved trans-membrane domains but otherwise no other characterized domains. NKAINs may function as subunits of pore or channel structures in neurons or they may affect the function of other membrane proteins. They are likely to function within the membrane bilayer.","GO:0002028|regulation of sodium ion transport;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0051117|ATPase binding;","K22735","NKAIN; sodium/potassium-transporting ATPase subunit beta-1-interacting protein"]
["ENSRNOG00000066172",4,0.332106642,33,2.12290446,0.15643975,-2.676320963,{"v":8.03272e-06,"d":"8.03E-06"},{"v":1.09352E-5,"d":"1.09E-05"},"down","yes","ENSRNOG00000066172","pseudogene","chr4:125334071-125357800:+","gi|26335481|dbj|BAC31441.1|",380,{"v":6e-44,"d":"6.00E-44"},"unnamed protein product [Mus musculus]","gi|755518147|ref|XR_035139.5|",181,{"v":3e-88,"d":"3.00E-88"},"PREDICTED: Mus musculus RIKEN cDNA A730049H05 gene (A730049H05Rik), transcript variant X2, misc_RNA",".",".",".",".",".",".",".",".","pfam00090","TSP_1","Thrombospondin type 1 domain.",".",".",".",".","."]
["ENSRNOG00000008716",24,1.992639853,80,5.146435055,0.38718838,-1.368892438,{"v":8.22234e-06,"d":"8.22E-06"},{"v":1.11789e-05,"d":"1.12E-05"},"down","yes","Nefh","protein_coding","chr14:79830362-79840351:-","gi|158341642|ref|NP_036739.2|",1706,0,"neurofilament heavy polypeptide [Rattus norvegicus]","gi|158341641|ref|NM_012607.2|",3843,0,"Rattus norvegicus neurofilament, heavy polypeptide (Nefh), mRNA","P16884",637,0,"Neurofilament heavy polypeptide","YPO0743",57.4,1e-07,"COG3144","pfam00038","Filament","Intermediate filament protein.","GO:0000226|microtubule cytoskeleton organization;GO:0001552|ovarian follicle atresia;GO:0007420|brain development;GO:0021510|spinal cord development;GO:0021766|hippocampus development;GO:0021987|cerebral cortex development;GO:0031103|axon regeneration;GO:0031175|neuron projection development;GO:0033693|neurofilament bundle assembly;GO:0034599|cellular response to oxidative stress;GO:0042220|response to cocaine;GO:0045104|intermediate filament cytoskeleton organization;GO:0045110|intermediate filament bundle assembly;GO:0048936|peripheral nervous system neuron axonogenesis;GO:0060052|neurofilament cytoskeleton organization;GO:0061564|axon development;GO:0071392|cellular response to estradiol stimulus;GO:0071447|cellular response to hydroperoxide;GO:0099185|postsynaptic intermediate filament cytoskeleton organization;GO:1902513|regulation of organelle transport along microtubule;GO:1903935|response to sodium arsenite;GO:1903937|response to acrylamide;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005882|intermediate filament;GO:0005883|neurofilament;GO:0014069|postsynaptic density;GO:0030424|axon;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0097418|neurofibrillary tangle;GO:0097440|apical dendrite;GO:0098685|Schaffer collateral - CA1 synapse;GO:0099160|postsynaptic intermediate filament cytoskeleton;GO:0150017|basal proximal dendrite;","GO:0005200|structural constituent of cytoskeleton;GO:0015643|toxic substance binding;GO:0019901|protein kinase binding;GO:0030674|protein binding, bridging;GO:0044877|protein-containing complex binding;GO:0099184|structural constituent of postsynaptic intermediate filament cytoskeleton;","K04574","NEFH, NF-H; neurofilament heavy polypeptide"]
["ENSRNOG00000011310",29,2.407773155,90,5.789739437,0.415869001,-1.265798945,{"v":8.48997e-06,"d":"8.49E-06"},{"v":1.15256E-5,"d":"1.15E-05"},"down","yes","Pde10a","protein_coding","chr1:51770132-52216563:-","gi|42600933|gb|AAS21243.1|",4505,0,"PDE10A11 [Rattus norvegicus]","gi|13489074|ref|NM_022236.1|",3042,0,"Rattus norvegicus phosphodiesterase 10A (Pde10a), mRNA","Q8CA95",1616,0,"cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A",".",".",".",".","pfam00233","PDEase_I","3'5'-cyclic nucleotide phosphodiesterase.","GO:0006198|cAMP catabolic process;GO:0007165|signal transduction;GO:0010738|regulation of protein kinase A signaling;GO:0010754|negative regulation of cGMP-mediated signaling;GO:0043951|negative regulation of cAMP-mediated signaling;GO:0046069|cGMP catabolic process;GO:0106070|regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway;","GO:0005737|cytoplasm;GO:0016020|membrane;GO:0043025|neuronal cell body;GO:0043204|perikaryon;","GO:0004112|cyclic-nucleotide phosphodiesterase activity;GO:0004114|3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0004115|3',5'-cyclic-AMP phosphodiesterase activity;GO:0004118|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity;GO:0030552|cAMP binding;GO:0030553|cGMP binding;GO:0046872|metal ion binding;GO:0047555|3',5'-cyclic-GMP phosphodiesterase activity;","K18438","PDE10; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10 [EC:3.1.4.17 3.1.4.35]"]
["ENSRNOG00000006726",48,3.985279705,126,8.105635211,0.491667784,-1.024244267,{"v":8.78566e-06,"d":"8.79E-06"},{"v":1.18892E-5,"d":"1.19E-05"},"down","yes","Zfp9","protein_coding","chr4:151638711-151656803:-","gi|189083704|ref|NP_001121107.1|",2385,0,"zinc finger protein 25 [Rattus norvegicus]","gi|219282699|ref|NM_001127635.2|",2284,0,"Rattus norvegicus zinc finger protein 9 (Zfp9), mRNA","P17030",729,0,"Zinc finger protein 25",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006355|regulation of transcription, DNA-templated;",".","GO:0046872|metal ion binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSRNOG00000060520",48,3.985279705,126,8.105635211,0.491667784,-1.024244267,{"v":8.78566e-06,"d":"8.79E-06"},{"v":1.18892E-5,"d":"1.19E-05"},"down","yes","AABR07048387.1","protein_coding","chr5:73866334-73956444:-","gi|672019425|ref|XP_008774197.1|",6948,0,"PREDICTED: uncharacterized protein C9orf84 homolog [Rattus norvegicus]","gi|672052764|ref|XM_008763751.1|",4045,0,"PREDICTED: Rattus norvegicus hypothetical protein LOC686050 (LOC686050), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam08928","DUF1910","Domain of unknown function (DUF1910). This domain is found in a set of hypothetical bacterial proteins.",".",".",".",".","."]
["ENSRNOG00000004712",40,3.321066421,111,7.140678639,0.465091147,-1.104414615,{"v":9.13859e-06,"d":"9.14E-06"},{"v":1.23459E-5,"d":"1.23E-05"},"down","yes","ENSRNOG00000004712","protein_coding","chr13:68962991-68992570:+","gi|149058319|gb|EDM09476.1|",2312,0,"rCG46196 [Rattus norvegicus]","gi|74210754|dbj|AK142319.1|",1238,0,"Mus musculus 13 days embryo heart cDNA, RIKEN full-length enriched library, clone:D330049I06 product:angiopoietin-like 1, full insert sequence","Q640P2",856,0,"Angiopoietin-related protein 1",".",".",".",".","pfam00147","Fibrinogen_C","Fibrinogen beta and gamma chains, C-terminal globular domain.","GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;","GO:0005615|extracellular space;GO:0062023|collagen-containing extracellular matrix;","GO:0005102|signaling receptor binding;","K25356","ANGPTL1, ANG3; angiopoietin-related protein 1"]
["ENSRNOG00000058329",39,3.23803976,109,7.012017762,0.461784307,-1.11470895,{"v":9.44381E-6,"d":"9.44E-06"},{"v":1.2731e-05,"d":"1.27E-05"},"down","yes","Prrx2","protein_coding","chr3:14094004-14168535:+","gi|157787036|ref|NP_001099209.1|",693,{"v":1E-84,"d":"1.00E-84"},"paired mesoderm homeobox protein 2 [Rattus norvegicus]","gi|157787035|ref|NM_001105739.1|",1215,0,"Rattus norvegicus paired related homeobox 2 (Prrx2), mRNA","Q99811",266,{"v":3e-84,"d":"3.00E-84"},"Paired mesoderm homeobox protein 2","ECU03g1170",50.8,2e-06,"COG5576","pfam00046","Homeobox","Homeobox domain.","GO:0002053|positive regulation of mesenchymal cell proliferation;GO:0006357|regulation of transcription by RNA polymerase II;GO:0030326|embryonic limb morphogenesis;GO:0042472|inner ear morphogenesis;GO:0042474|middle ear morphogenesis;GO:0045880|positive regulation of smoothened signaling pathway;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048701|embryonic cranial skeleton morphogenesis;GO:0048704|embryonic skeletal system morphogenesis;GO:0048844|artery morphogenesis;GO:0051216|cartilage development;","GO:0005634|nucleus;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0071837|HMG box domain binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09329","PRRX, PMX; paired mesoderm homeobox protein"]
["ENSRNOG00000009436",7,0.581186624,41,2.637547966,0.220351111,-2.182123926,{"v":9.86992e-06,"d":"9.87E-06"},{"v":1.32722E-5,"d":"1.33E-05"},"down","yes","Hemgn","protein_coding","chr5:60679633-60698669:-","gi|672052524|ref|XP_008761915.1|",2627,0,"PREDICTED: hemogen isoform X1 [Rattus norvegicus]","gi|672052525|ref|XM_008763694.1|",2639,0,"PREDICTED: Rattus norvegicus hemogen (Hemgn), transcript variant X2, mRNA","Q6AZ54",1016,0,"Hemogen",".",".",".",".","pfam11489","DUF3210","Protein of unknown function (DUF3210). This is a family of proteins conserved in yeasts. The function is not known. The Schizosaccharomyces pombe member is SPBC18E5.07 and the Saccharomyces cerevisiae member is AIM21.","GO:0030154|cell differentiation;GO:0045667|regulation of osteoblast differentiation;","GO:0005654|nucleoplasm;",".",".","."]
["ENSRNOG00000025404",11,0.913293266,51,3.280852347,0.278370731,-1.844920567,{"v":9.93117e-06,"d":"9.93E-06"},{"v":1.33517E-5,"d":"1.34E-05"},"down","yes","Dppa4","protein_coding","chr11:52570286-52578797:-","gi|293352174|ref|XP_001063552.2|",1224,{"v":3e-163,"d":"3.00E-163"},"PREDICTED: developmental pluripotency-associated protein 4 isoform X1 [Rattus norvegicus]","gi|672026020|ref|XM_003752488.3|",1220,0,"PREDICTED: Rattus norvegicus similar to developmental pluripotency associated 4 isoform 1 (LOC685378), transcript variant X1, mRNA","D3Z8Y2",471,{"v":8e-163,"d":"8.00E-163"},"Developmental pluripotency-associated protein 4",".",".",".",".","pfam14047","DCR","Dppa2/4 conserved region. This domain has been characterized in the finding of a developmental pluripotency associated gene (Dppa) in the lower vertebrate Xenopus laevis. Previous to this discovery, Dppa genes were known only in higher vertebrates. The domain is subject to structure determination by the Joint Center of Structural Genomics.","GO:0048731|system development;GO:0060484|lung-associated mesenchyme development;","GO:0005634|nucleus;","GO:0003682|chromatin binding;",".","."]
["ENSRNOG00000023101",2,0.166053321,26,1.672591393,0.099279072,-3.332366562,{"v":1.06378E-5,"d":"1.06E-05"},{"v":1.42478e-05,"d":"1.42E-05"},"down","yes","AABR07047835.1","protein_coding","chr5:48925362-48927475:+","gi|564348552|ref|XP_006237244.1|",1348,0,"PREDICTED: chondroitin sulfate N-acetylgalactosaminyltransferase 2 isoform X2 [Rattus norvegicus]","gi|672050825|ref|XM_006237182.2|",735,0,"PREDICTED: Rattus norvegicus chondroitin sulfate N-acetylgalactosaminyltransferase 2 (Csgalnact2), transcript variant X2, mRNA","Q8C1F4",507,{"v":3E-176,"d":"3.00E-176"},"Chondroitin sulfate N-acetylgalactosaminyltransferase 2",".",".",".",".","pfam05679","CHGN","Chondroitin N-acetylgalactosaminyltransferase.",".",".",".",".","."]
["ENSRNOG00000065189",2,0.166053321,26,1.672591393,0.099279072,-3.332366562,{"v":1.06378E-5,"d":"1.06E-05"},{"v":1.42478e-05,"d":"1.42E-05"},"down","yes","ENSRNOG00000065189","protein_coding","chr15:4589987-4599799:-","gi|564317541|ref|XP_006221948.1|",1022,{"v":3E-134,"d":"3.00E-134"},"PREDICTED: disks large homolog 5-like isoform X1 [Rattus norvegicus]","gi|672077738|ref|XM_008770593.1|",878,0,"PREDICTED: Rattus norvegicus disks large homolog 5-like (LOC102550466), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam04822","Takusan","Takusan. This domain is named takusan, which is a Japanese word meaning 'many'. Members of this family regulate synaptic activity.",".",".",".",".","."]
["ENSRNOG00000052128",6,0.498159963,38,2.444556651,0.203783358,-2.294891857,{"v":1.14122e-05,"d":"1.14E-05"},{"v":1.52117E-5,"d":"1.52E-05"},"down","yes","Clec2e","protein_coding","chr4:162534278-162541971:-","gi|672051253|ref|XP_008761558.1|",1052,{"v":4e-132,"d":"4.00E-132"},"PREDICTED: C-type lectin domain family 2 member E isoform X1 [Rattus norvegicus]","gi|672051252|ref|XM_008763336.1|",1653,0,"PREDICTED: Rattus norvegicus C-type lectin domain family 2, member E (Clec2e), transcript variant X1, mRNA","Q80XD9",304,{"v":2e-94,"d":"2.00E-94"},"C-type lectin domain family 2 member E",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type",".","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0030246|carbohydrate binding;GO:0046703|natural killer cell lectin-like receptor binding;","K10072","CLEC2D; C-type lectin domain family 2 member D"]
["ENSRNOG00000070106",48,3.985279705,125,8.041304773,0.495601127,-1.012748628,{"v":1.15216E-5,"d":"1.15E-05"},{"v":1.53511e-05,"d":"1.54E-05"},"down","yes","ENSRNOG00000070106","protein_coding","chr17:2513964-2557102:+","gi|564319318|ref|XP_006222365.1|",3182,0,"PREDICTED: zinc finger protein 431-like [Rattus norvegicus]","gi|672029658|ref|XM_006222309.2|",2246,0,"PREDICTED: Rattus norvegicus zinc finger protein 665-like (LOC102551451), transcript variant X1, mRNA","Q96IR2",724,0,"Zinc finger protein 845",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000027240",12,0.996319926,53,3.409513224,0.292217645,-1.774884798,{"v":1.15247E-5,"d":"1.15E-05"},{"v":1.53521e-05,"d":"1.54E-05"},"down","yes","Kndc1","protein_coding","chr1:194690135-194738362:+","gi|564299095|ref|XP_006223762.1|",8487,0,"PREDICTED: protein very KIND isoform X1 [Rattus norvegicus]","gi|145864472|ref|NM_177261.4|",5670,0,"Mus musculus kinase non-catalytic C-lobe domain (KIND) containing 1 (Kndc1), mRNA","Q0KK55",3216,0,"Kinase non-catalytic C-lobe domain-containing protein 1",".",".",".",".","pfam00617","RasGEF","RasGEF domain. Guanine nucleotide exchange factor for Ras-like small GTPases.","GO:0001934|positive regulation of protein phosphorylation;GO:0007264|small GTPase mediated signal transduction;GO:0008150|biological_process;GO:0021707|cerebellar granule cell differentiation;GO:0048814|regulation of dendrite morphogenesis;GO:0050773|regulation of dendrite development;GO:0050790|regulation of catalytic activity;","GO:0005575|cellular_component;GO:0030425|dendrite;GO:0032045|guanyl-nucleotide exchange factor complex;GO:0043025|neuronal cell body;","GO:0003674|molecular_function;GO:0005085|guanyl-nucleotide exchange factor activity;",".","."]
["ENSRNOG00000026053",28,2.324746495,87,5.596748122,0.415374507,-1.267515418,{"v":1.17467e-05,"d":"1.17E-05"},{"v":1.5624e-05,"d":"1.56E-05"},"down","yes","Grem1","protein_coding","chr3:100512313-100524082:-","gi|585648865|ref|XP_006883110.1|",775,{"v":1E-91,"d":"1.00E-91"},"PREDICTED: gremlin-1 isoform X1 [Elephantulus edwardii]","gi|393794769|ref|NM_019282.3|",3656,0,"Rattus norvegicus gremlin 1 (Grem1), mRNA","O35793",302,{"v":5e-93,"d":"5.00E-93"},"Gremlin-1",".",".",".",".","pfam03045","DAN","DAN domain. This domain contains 9 conserved cysteines and is extracellular. Therefore the cysteines may form disulphide bridges. This family of proteins has been termed the DAN family after the first member to be reported. This family includes DAN, Cerberus and Gremlin. The gremlin protein is an antagonist of bone morphogenetic protein signaling. It is postulated that all members of this family antagonise different TGF beta pfam00019 ligands. Recent work shows that the DAN protein is not an efficient antagonist of BMP-2/4 class signals, we found that DAN was able to interact with GDF-5 in a frog embryo assay, suggesting that DAN may regulate signaling by the GDF-5/6/7 class of BMPs in vivo.","GO:0000902|cell morphogenesis;GO:0001525|angiogenesis;GO:0002042|cell migration involved in sprouting angiogenesis;GO:0002092|positive regulation of receptor internalization;GO:0002689|negative regulation of leukocyte chemotaxis;GO:0003257|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation;GO:0003337|mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0006915|apoptotic process;GO:0007165|signal transduction;GO:0007171|activation of transmembrane receptor protein tyrosine kinase activity;GO:0007267|cell-cell signaling;GO:0008284|positive regulation of cell proliferation;GO:0009887|animal organ morphogenesis;GO:0009954|proximal/distal pattern formation;GO:0010717|regulation of epithelial to mesenchymal transition;GO:0030199|collagen fibril organization;GO:0030308|negative regulation of cell growth;GO:0030326|embryonic limb morphogenesis;GO:0030502|negative regulation of bone mineralization;GO:0030514|negative regulation of BMP signaling pathway;GO:0032331|negative regulation of chondrocyte differentiation;GO:0033689|negative regulation of osteoblast proliferation;GO:0038098|sequestering of BMP from receptor via BMP binding;GO:0043066|negative regulation of apoptotic process;GO:0043542|endothelial cell migration;GO:0045668|negative regulation of osteoblast differentiation;GO:0045766|positive regulation of angiogenesis;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046851|negative regulation of bone remodeling;GO:0048263|determination of dorsal identity;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051893|regulation of focal adhesion assembly;GO:0051973|positive regulation of telomerase activity;GO:0060173|limb development;GO:0060394|negative regulation of pathway-restricted SMAD protein phosphorylation;GO:0060676|ureteric bud formation;GO:0061098|positive regulation of protein tyrosine kinase activity;GO:0090027|negative regulation of monocyte chemotaxis;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0090190|positive regulation of branching involved in ureteric bud morphogenesis;GO:0090291|negative regulation of osteoclast proliferation;GO:1900086|positive regulation of peptidyl-tyrosine autophosphorylation;GO:1900155|negative regulation of bone trabecula formation;GO:1900158|negative regulation of bone mineralization involved in bone maturation;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:2000273|positive regulation of signaling receptor activity;GO:2000727|positive regulation of cardiac muscle cell differentiation;","GO:0005615|extracellular space;GO:0009986|cell surface;","GO:0005125|cytokine activity;GO:0005515|protein binding;GO:0030297|transmembrane receptor protein tyrosine kinase activator activity;GO:0036122|BMP binding;GO:0042803|protein homodimerization activity;GO:0043184|vascular endothelial growth factor receptor 2 binding;GO:0048018|receptor ligand activity;","K23318","GREM; gremlin"]
["ENSRNOG00000010868",41,3.404093082,112,7.205009077,0.472462012,-1.081729761,{"v":1.17484e-05,"d":"1.17E-05"},{"v":1.5624e-05,"d":"1.56E-05"},"down","yes","Rims4","protein_coding","chr3:152524095-152584780:-","gi|33942097|ref|NP_898844.1|",1426,0,"regulating synaptic membrane exocytosis protein 4 [Mus musculus]","gi|672047994|ref|XM_008762471.1|",1845,0,"PREDICTED: Rattus norvegicus regulating synaptic membrane exocytosis 4 (Rims4), transcript variant X1, mRNA","P60191",553,0,"Regulating synaptic membrane exocytosis protein 4",".",".",".",".","pfam00168","C2","C2 domain.","GO:0006836|neurotransmitter transport;GO:0006887|exocytosis;GO:0007269|neurotransmitter secretion;GO:0042391|regulation of membrane potential;GO:0050807|regulation of synapse organization;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0045202|synapse;GO:0097060|synaptic membrane;GO:0098793|presynapse;GO:0098978|glutamatergic synapse;","GO:0031267|small GTPase binding;GO:0044325|ion channel binding;","K15299","RIMS4, RIM4; regulating synaptic membrane exocytosis protein 4"]
["ENSRNOG00000012363",46,3.819226384,121,7.78398302,0.490651942,-1.027228125,{"v":1.26295E-5,"d":"1.26E-05"},{"v":1.67089e-05,"d":"1.67E-05"},"down","yes","Peli2","protein_coding","chr15:21393262-21535106:+","gi|157822359|ref|NP_001100729.1|",2271,0,"E3 ubiquitin-protein ligase pellino homolog 2 [Rattus norvegicus]","gi|157822358|ref|NM_001107259.1|",3239,0,"Rattus norvegicus pellino E3 ubiquitin protein ligase family member 2 (Peli2), mRNA","Q8BST6",850,0,"E3 ubiquitin-protein ligase pellino homolog 2",".",".",".",".","pfam04710","Pellino","Pellino. Pellino is involved in Toll-like signalling pathways, and associates with the kinase domain of the Pelle Ser/Thr kinase.","GO:0000209|protein polyubiquitination;GO:0001934|positive regulation of protein phosphorylation;GO:0008063|Toll signaling pathway;GO:0008150|biological_process;GO:0008592|regulation of Toll signaling pathway;GO:0043410|positive regulation of MAPK cascade;","GO:0005575|cellular_component;GO:0005829|cytosol;GO:0016020|membrane;","GO:0003674|molecular_function;GO:0030674|protein binding, bridging;GO:0061630|ubiquitin protein ligase activity;","K11964","PELI; pellino [EC:2.3.2.27]"]
["ENSRNOG00000061731",3,0.249079982,29,1.865582707,0.133513235,-2.904945338,{"v":1.26504E-5,"d":"1.27E-05"},{"v":1.67331e-05,"d":"1.67E-05"},"down","yes","Plxnb3","protein_coding","chrX:151494207-151508674:+","gi|209529650|ref|NP_001129350.1|",9274,0,"plexin-B3 precursor [Rattus norvegicus]","gi|672088967|ref|XM_006229587.2|",6100,0,"PREDICTED: Rattus norvegicus plexin B3 (Plxnb3), transcript variant X3, mRNA","D3ZLH5",3573,0,"Plexin-B3",".",".",".",".","pfam08337","Plexin_cytopl","Plexin cytoplasmic RasGAP domain. This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.","GO:0001938|positive regulation of endothelial cell proliferation;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007162|negative regulation of cell adhesion;GO:0008360|regulation of cell shape;GO:0010593|negative regulation of lamellipodium assembly;GO:0010976|positive regulation of neuron projection development;GO:0030334|regulation of cell migration;GO:0030336|negative regulation of cell migration;GO:0034260|negative regulation of GTPase activity;GO:0043087|regulation of GTPase activity;GO:0050772|positive regulation of axonogenesis;GO:0050918|positive chemotaxis;GO:0060326|cell chemotaxis;GO:0071526|semaphorin-plexin signaling pathway;GO:1902287|semaphorin-plexin signaling pathway involved in axon guidance;","GO:0002116|semaphorin receptor complex;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;","GO:0017154|semaphorin receptor activity;GO:0019904|protein domain specific binding;GO:0051022|Rho GDP-dissociation inhibitor binding;GO:0098632|cell-cell adhesion mediator activity;","K06821","PLXNB; plexin B"]
["ENSRNOG00000062794",1,0.083026661,22,1.41526964,0.058664906,-4.091358462,{"v":1.29709E-5,"d":"1.30E-05"},{"v":1.71252E-5,"d":"1.71E-05"},"down","yes","Gypa","protein_coding","chr19:27450308-27465822:-","gi|149037943|gb|EDL92303.1|",499,{"v":9e-58,"d":"9.00E-58"},"rCG51636 [Rattus norvegicus]","gi|298904585|emb|FQ225003.1|",1211,0,"Rattus norvegicus TL0AEA55YH08 mRNA sequence","P14220",76.3,{"v":9e-15,"d":"9.00E-15"},"Glycophorin-A",".",".",".",".","pfam01102","Glycophorin_A","Glycophorin A.",".",".",".",".","."]
["ENSRNOG00000017130",4,0.332106642,32,2.058574022,0.161328492,-2.631926844,{"v":1.32091E-5,"d":"1.32E-05"},{"v":1.74001E-5,"d":"1.74E-05"},"down","yes","Rhd","protein_coding","chr5:147087518-147121715:+","gi|11968076|ref|NP_071950.1|",2164,0,"blood group Rh(D) polypeptide [Rattus norvegicus]","gi|40254767|ref|NM_022505.2|",1482,0,"Rattus norvegicus Rh blood group, D antigen (Rhd), mRNA","O88298",838,0,"Blood group Rh(D) polypeptide",".",".",".",".","pfam00909","Ammonium_transp","Ammonium Transporter Family.","GO:0015696|ammonium transport;GO:0048821|erythrocyte development;GO:0060586|multicellular organismal iron ion homeostasis;GO:0072488|ammonium transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0016020|membrane;","GO:0008519|ammonium transmembrane transporter activity;","K06579","RH, CD240; Rhesus blood group glycoprotein"]
["ENSRNOG00000066847",36,2.988959779,102,6.561704695,0.455515741,-1.134427184,{"v":1.38731e-05,"d":"1.39E-05"},{"v":1.82335e-05,"d":"1.82E-05"},"down","yes","Gnrh1","protein_coding","chr15:41942339-41976690:+","gi|157820083|ref|NP_001102341.1|",1971,0,"BTB/POZ domain-containing protein KCTD9 [Rattus norvegicus]","gi|672078361|ref|XM_006252142.2|",3393,0,"PREDICTED: Rattus norvegicus potassium channel tetramerization domain containing 9 (Kctd9), transcript variant X2, mRNA","Q7L273",753,0,"BTB/POZ domain-containing protein KCTD9","MA3328",114,{"v":5e-26,"d":"5.00E-26"},"COG1357","pfam02214","BTB_2","BTB/POZ domain. In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.",".",".",".",".","."]
["ENSRNOG00000029342",16,1.328426568,61,3.924156729,0.33852536,-1.562664181,{"v":1.7208e-05,"d":"1.72E-05"},{"v":2.24321e-05,"d":"2.24E-05"},"down","yes","Scn7a","protein_coding","chr3:51335841-51438256:-","gi|564341195|ref|XP_006234358.1|",8480,0,"PREDICTED: sodium channel protein type 7 subunit alpha isoform X1 [Rattus norvegicus]","gi|672045864|ref|XM_006234296.2|",6630,0,"PREDICTED: Rattus norvegicus sodium channel, voltage-gated, type VII, alpha subunit (Scn7a), transcript variant X1, mRNA","Q01118",2394,0,"Sodium channel protein type 7 subunit alpha",".",".",".",".","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0006814|sodium ion transport;GO:0006936|muscle contraction;GO:0009617|response to bacterium;GO:0019228|neuronal action potential;GO:0034765|regulation of ion transmembrane transport;GO:0035725|sodium ion transmembrane transport;GO:0055078|sodium ion homeostasis;GO:0086010|membrane depolarization during action potential;","GO:0001518|voltage-gated sodium channel complex;GO:0005886|plasma membrane;GO:0030424|axon;GO:0097386|glial cell projection;","GO:0005244|voltage-gated ion channel activity;GO:0005248|voltage-gated sodium channel activity;GO:0005272|sodium channel activity;","K04839","SCN7A, SCN6A; voltage-gated sodium channel type VII alpha"]
["ENSRNOG00000069679",2,0.166053321,25,1.608260955,0.103250235,-3.275783034,{"v":1.8129e-05,"d":"1.81E-05"},{"v":2.35559e-05,"d":"2.36E-05"},"down","yes","ENSRNOG00000069679","lncRNA","chr7:127402737-127422676:-",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","pfam03568","Peptidase_C50","Peptidase family C50.",".",".",".",".","."]
["ENSRNOG00000032639",36,2.988959779,101,6.497374257,0.460025798,-1.120213325,{"v":1.8618E-5,"d":"1.86E-05"},{"v":2.4152e-05,"d":"2.42E-05"},"down","yes","Foxo6","protein_coding","chr5:133856072-133876573:-","gi|109475418|ref|XP_001057233.1|",1080,{"v":8e-131,"d":"8.00E-131"},"PREDICTED: forkhead box protein O6 [Rattus norvegicus]","gi|564352641|ref|XM_001057233.4|",2124,0,"PREDICTED: Rattus norvegicus forkhead box O6 (Foxo6), mRNA","Q70KY4",417,{"v":4e-131,"d":"4.00E-131"},"Forkhead box protein O6","ECU01g0470",60.8,2e-09,"COG5025","pfam00250","Fork_head","Fork head domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0007613|memory;GO:0060999|positive regulation of dendritic spine development;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;","K17847","FOXO6; forkhead box protein O6"]
["ENSRNOG00000019680",8,0.664213284,42,2.701878404,0.245833892,-2.024244267,{"v":1.99889e-05,"d":"2.00E-05"},{"v":2.58048e-05,"d":"2.58E-05"},"down","yes","Mst1","protein_coding","chr8:108768839-108773416:+","gi|564365338|ref|XP_006243768.1|",3856,0,"PREDICTED: hepatocyte growth factor-like protein isoform X1 [Rattus norvegicus]","gi|564365337|ref|XM_006243706.1|",2298,0,"PREDICTED: Rattus norvegicus Macrophage stimulating 1 (hepatocyte growth factor-like) (Mst1), transcript variant X1, mRNA","P26928",1361,0,"Hepatocyte growth factor-like protein","VC1649",73.9,{"v":7e-13,"d":"7.00E-13"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;GO:0007283|spermatogenesis;GO:0007566|embryo implantation;GO:0010628|positive regulation of gene expression;GO:0010758|regulation of macrophage chemotaxis;GO:0030317|flagellated sperm motility;GO:0030879|mammary gland development;GO:0033601|positive regulation of mammary gland epithelial cell proliferation;GO:0035978|histone H2A-S139 phosphorylation;GO:0045721|negative regulation of gluconeogenesis;GO:0046425|regulation of JAK-STAT cascade;GO:0060763|mammary duct terminal end bud growth;GO:0071456|cellular response to hypoxia;GO:1904036|negative regulation of epithelial cell apoptotic process;GO:2000479|regulation of cAMP-dependent protein kinase activity;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005773|vacuole;","GO:0005102|signaling receptor binding;GO:0019899|enzyme binding;GO:0030971|receptor tyrosine kinase binding;","K23441","MST1; hepatocyte growth factor-like protein"]
["ENSRNOG00000010278",3,0.249079982,28,1.801252269,0.138281564,-2.854319265,{"v":2.11391e-05,"d":"2.11E-05"},{"v":2.71854e-05,"d":"2.72E-05"},"down","yes","Il6","protein_coding","chr4:5213394-5219178:-","gi|7549769|ref|NP_036721.1|",1097,{"v":2e-142,"d":"2.00E-142"},"interleukin-6 precursor [Rattus norvegicus]","gi|204919|gb|M26745.1|RATIL6G",1710,0,"Rat interleukin 6 (IL6) gene, complete cds","P20607",427,{"v":6e-144,"d":"6.00E-144"},"Interleukin-6",".",".",".",".","pfam00489","IL6","Interleukin-6/G-CSF/MGF family.","GO:0001781|neutrophil apoptotic process;GO:0001878|response to yeast;GO:0002262|myeloid cell homeostasis;GO:0002314|germinal center B cell differentiation;GO:0002384|hepatic immune response;GO:0002526|acute inflammatory response;GO:0002639|positive regulation of immunoglobulin production;GO:0002675|positive regulation of acute inflammatory response;GO:0006469|negative regulation of protein kinase activity;GO:0006953|acute-phase response;GO:0006954|inflammatory response;GO:0007568|aging;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0008360|regulation of cell shape;GO:0009408|response to heat;GO:0009409|response to cold;GO:0009410|response to xenobiotic stimulus;GO:0009611|response to wounding;GO:0009612|response to mechanical stimulus;GO:0009617|response to bacterium;GO:0010467|gene expression;GO:0010573|vascular endothelial growth factor production;GO:0010574|regulation of vascular endothelial growth factor production;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0010628|positive regulation of gene expression;GO:0010718|positive regulation of epithelial to mesenchymal transition;GO:0010976|positive regulation of neuron projection development;GO:0010996|response to auditory stimulus;GO:0014015|positive regulation of gliogenesis;GO:0014070|response to organic cyclic compound;GO:0014823|response to activity;GO:0019221|cytokine-mediated signaling pathway;GO:0031000|response to caffeine;GO:0031018|endocrine pancreas development;GO:0031175|neuron projection development;GO:0031294|lymphocyte costimulation;GO:0031667|response to nutrient levels;GO:0031669|cellular response to nutrient levels;GO:0032496|response to lipopolysaccharide;GO:0032682|negative regulation of chemokine production;GO:0032722|positive regulation of chemokine production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032733|positive regulation of interleukin-10 production;GO:0032740|positive regulation of interleukin-17 production;GO:0032745|positive regulation of interleukin-21 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032868|response to insulin;GO:0032966|negative regulation of collagen biosynthetic process;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0034097|response to cytokine;GO:0035729|cellular response to hepatocyte growth factor stimulus;GO:0042060|wound healing;GO:0042102|positive regulation of T cell proliferation;GO:0042110|T cell activation;GO:0042127|regulation of cell proliferation;GO:0042307|positive regulation of protein import into nucleus;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0042593|glucose homeostasis;GO:0042832|defense response to protozoan;GO:0042981|regulation of apoptotic process;GO:0043065|positive regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043200|response to amino acid;GO:0043410|positive regulation of MAPK cascade;GO:0045188|regulation of circadian sleep/wake cycle, non-REM sleep;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0045454|cell redox homeostasis;GO:0045630|positive regulation of T-helper 2 cell differentiation;GO:0045666|positive regulation of neuron differentiation;GO:0045669|positive regulation of osteoblast differentiation;GO:0045721|negative regulation of gluconeogenesis;GO:0045727|positive regulation of translation;GO:0045740|positive regulation of DNA replication;GO:0045779|negative regulation of bone resorption;GO:0045837|negative regulation of membrane potential;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046427|positive regulation of JAK-STAT cascade;GO:0046677|response to antibiotic;GO:0046716|muscle cell cellular homeostasis;GO:0046849|bone remodeling;GO:0046888|negative regulation of hormone secretion;GO:0048635|negative regulation of muscle organ development;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0050679|positive regulation of epithelial cell proliferation;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050796|regulation of insulin secretion;GO:0050871|positive regulation of B cell activation;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051384|response to glucocorticoid;GO:0051592|response to calcium ion;GO:0051602|response to electrical stimulus;GO:0051607|defense response to virus;GO:0051897|positive regulation of protein kinase B signaling;GO:0051971|positive regulation of transmission of nerve impulse;GO:0060252|positive regulation of glial cell proliferation;GO:0060445|branching involved in salivary gland morphogenesis;GO:0060664|epithelial cell proliferation involved in salivary gland morphogenesis;GO:0061470|T follicular helper cell differentiation;GO:0070091|glucagon secretion;GO:0070092|regulation of glucagon secretion;GO:0070102|interleukin-6-mediated signaling pathway;GO:0070301|cellular response to hydrogen peroxide;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071222|cellular response to lipopolysaccharide;GO:0071345|cellular response to cytokine stimulus;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071392|cellular response to estradiol stimulus;GO:0071549|cellular response to dexamethasone stimulus;GO:0071864|positive regulation of cell proliferation in bone marrow;GO:0072540|T-helper 17 cell lineage commitment;GO:0072574|hepatocyte proliferation;GO:0090091|positive regulation of extracellular matrix disassembly;GO:0097421|liver regeneration;GO:0098586|cellular response to virus;GO:1900017|positive regulation of cytokine production involved in inflammatory response;GO:1901215|negative regulation of neuron death;GO:1901731|positive regulation of platelet aggregation;GO:1902512|positive regulation of apoptotic DNA fragmentation;GO:1903800|positive regulation of production of miRNAs involved in gene silencing by miRNA;GO:1904894|positive regulation of STAT cascade;GO:1904996|positive regulation of leukocyte adhesion to vascular endothelial cell;GO:1990646|cellular response to prolactin;GO:2000553|positive regulation of T-helper 2 cell cytokine production;GO:2000635|negative regulation of primary miRNA processing;GO:2000660|negative regulation of interleukin-1-mediated signaling pathway;GO:2000866|positive regulation of estradiol secretion;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005896|interleukin-6 receptor complex;GO:0009897|external side of plasma membrane;","GO:0005102|signaling receptor binding;GO:0005125|cytokine activity;GO:0005138|interleukin-6 receptor binding;GO:0008083|growth factor activity;","K05405","IL6; interleukin 6"]
["ENSRNOG00000015035",3,0.249079982,28,1.801252269,0.138281564,-2.854319265,{"v":2.11391e-05,"d":"2.11E-05"},{"v":2.71854e-05,"d":"2.72E-05"},"down","yes","Myo7b","protein_coding","chr18:23588307-23669809:-","gi|564393105|ref|XP_006254662.1|",11336,0,"PREDICTED: unconventional myosin-VIIb isoform X1 [Rattus norvegicus]","gi|672083075|ref|XM_006254600.2|",6617,0,"PREDICTED: Rattus norvegicus myosin VIIb (Myo7b), transcript variant X1, mRNA","Q99MZ6",4081,0,"Unconventional myosin-VIIb","SPCC1919.10c",547,{"v":1e-162,"d":"1.00E-162"},"COG5022","pfam00063","Myosin_head","Myosin head (motor domain).","GO:0007015|actin filament organization;GO:0007423|sensory organ development;GO:0007605|sensory perception of sound;GO:0030050|vesicle transport along actin filament;GO:1904970|brush border assembly;","GO:0005737|cytoplasm;GO:0005902|microvillus;GO:0005903|brush border;GO:0015629|actin cytoskeleton;GO:0016459|myosin complex;GO:0031982|vesicle;GO:0090651|apical cytoplasm;","GO:0000146|microfilament motor activity;GO:0005524|ATP binding;GO:0051015|actin filament binding;","K21868","MYO7B; myosin VIIb"]
["ENSRNOG00000019404",14,1.162373247,56,3.602504538,0.322656983,-1.631926844,{"v":2.1411e-05,"d":"2.14E-05"},{"v":2.74963E-5,"d":"2.75E-05"},"down","yes","Hhatl","protein_coding","chr8:121447002-121454001:-","gi|157822045|ref|NP_001100338.1|",2570,0,"protein-cysteine N-palmitoyltransferase HHAT-like protein [Rattus norvegicus]","gi|157822044|ref|NM_001106868.1|",1626,0,"Rattus norvegicus hedgehog acyltransferase-like (Hhatl), mRNA","Q9D1G3",974,0,"Protein-cysteine N-palmitoyltransferase HHAT-like protein","YGL084c",67.4,{"v":6E-11,"d":"6.00E-11"},"COG1696","pfam03062","MBOAT","MBOAT, membrane-bound O-acyltransferase family. The MBOAT (membrane bound O-acyl transferase) family of membrane proteins contains a variety of acyltransferase enzymes. A conserved histidine has been suggested to be the active site residue.","GO:0060262|negative regulation of N-terminal protein palmitoylation;","GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;GO:0048471|perinuclear region of cytoplasm;","GO:0016746|transferase activity, transferring acyl groups;","K24679","HHATL; protein-cysteine N-palmitoyltransferase HHAT-like protein"]
["ENSRNOG00000021619",30,2.490799816,89,5.725408998,0.435043124,-1.200769679,{"v":2.1591E-5,"d":"2.16E-05"},{"v":2.77164e-05,"d":"2.77E-05"},"down","yes","Cela3b","protein_coding","chr5:149628773-149636937:-","gi|672054392|ref|XP_008762442.1|",1435,0,"PREDICTED: chymotrypsin-like elastase family member 3B isoform X1 [Rattus norvegicus]","gi|672054391|ref|XM_008764220.1|",949,0,"PREDICTED: Rattus norvegicus chymotrypsin-like elastase family, member 3B (Cela3b), transcript variant X1, mRNA","Q9CQ52",473,{"v":3e-167,"d":"3.00E-167"},"Chymotrypsin-like elastase family member 3B","VC1649",85.1,{"v":1e-17,"d":"1.00E-17"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;","GO:0005615|extracellular space;","GO:0004252|serine-type endopeptidase activity;","K01345","CELA3; pancreatic endopeptidase E [EC:3.4.21.70]"]
["ENSRNOG00000065348",23,1.909613192,75,4.824782864,0.395792566,-1.337183578,{"v":2.22592e-05,"d":"2.23E-05"},{"v":2.84941e-05,"d":"2.85E-05"},"down","yes","Pax9","protein_coding","chr6:74182568-74203506:+","gi|88014534|ref|NP_001034628.1|",1732,0,"paired box protein Pax-9 [Rattus norvegicus]","gi|88014533|ref|NM_001039539.1|",3743,0,"Rattus norvegicus paired box 9 (Pax9), mRNA","Q2L4T2",668,0,"Paired box protein Pax-9",".",".",".",".","pfam00292","PAX","'Paired box' domain.",".",".",".",".","."]
["ENSRNOG00000070584",9,0.747239945,44,2.83053928,0.263992077,-1.921433461,{"v":2.46316E-5,"d":"2.46E-05"},{"v":3.13864e-05,"d":"3.14E-05"},"down","yes","ENSRNOG00000070584","lncRNA","chr5:160127228-160135822:+",".",".",".",".","gi|149695906|emb|CU207384.8|",76,{"v":1e-29,"d":"1.00E-29"},"Mouse DNA sequence from clone DN-105C13 on chromosome 4, complete sequence",".",".",".",".",".",".",".",".","pfam15462","Barttin","Bartter syndrome, infantile, with sensorineural deafness (Barttin). Barttin is a family of mammalian proteins that are chloride ion channel beta-subunits crucial for renal Cl-re-absorption and inner ear K+ secretion. Bartter syndrome is a term covering a heterogeneous group of autosomal recessive salt-losing nephropathies that are caused by disturbed transepithelial sodium chloride re-absorption in the distal nephron. Mutations in the BCD proteins lead to sensorial deafness.",".",".",".",".","."]
["ENSRNOG00000025494",0,0.04151333,19,1.222278326,0.033963893,-4.879854357,{"v":2.4857e-05,"d":"2.49E-05"},{"v":3.1661e-05,"d":"3.17E-05"},"down","yes","Nsun7","protein_coding","chr14:41879293-41934949:-","gi|564383618|ref|XP_006251008.1|",3627,0,"PREDICTED: putative methyltransferase NSUN7 isoform X1 [Rattus norvegicus]","gi|672076151|ref|XM_006250946.2|",3508,0,"PREDICTED: Rattus norvegicus NOP2/Sun domain family, member 7 (Nsun7), transcript variant X1, mRNA","Q14AW5",1120,0,"Putative methyltransferase NSUN7","SPAC2C4.06c",72.8,{"v":2E-12,"d":"2.00E-12"},"COG0144","pfam03379","CcmB","CcmB protein. CcmB is the product of one of a cluster of Ccm genes that are necessary for cytochrome c biosynthesis in eubacteria. Expression of these proteins is induced when the organisms are grown under anaerobic conditions with nitrate or nitrite as the final electron acceptor. CcmB is required for the export of haem to the periplasm.","GO:0030317|flagellated sperm motility;GO:0030382|sperm mitochondrion organization;GO:0032259|methylation;",".","GO:0003723|RNA binding;GO:0008168|methyltransferase activity;",".","."]
["ENSRNOG00000069455",42,3.487119742,111,7.140678639,0.488345705,-1.034025287,{"v":2.61286e-05,"d":"2.61E-05"},{"v":3.32277E-5,"d":"3.32E-05"},"down","yes","ENSRNOG00000069455","lncRNA","chr13:55352567-55355339:-",".",".",".",".","gi|924182123|ref|NM_145991.2|",1215,0,"Mus musculus cell division cycle 73, Paf1/RNA polymerase II complex component (Cdc73), mRNA",".",".",".",".",".",".",".",".","pfam14897","EpsG","EpsG family. This family of proteins are related to the EpsG protein from B. subtilis. These proteins are likely glycosyl transferases belonging to the membrane protein GT-C clan.",".",".",".",".","."]
["ENSRNOG00000066548",21,1.743559871,70,4.503130673,0.38718838,-1.368892438,{"v":3.02863e-05,"d":"3.03E-05"},{"v":3.82035e-05,"d":"3.82E-05"},"down","yes","Rnf113a1","protein_coding","chrX:116427684-116433762:+","gi|62339353|ref|NP_001014791.1|",1744,0,"RING finger protein 113A [Rattus norvegicus]","gi|672088464|ref|XM_008773490.1|",1150,0,"PREDICTED: Rattus norvegicus ring finger protein 113A (Rnf113a), mRNA","O15541",585,0,"RING finger protein 113A","YLR323c",145,{"v":2e-38,"d":"2.00E-38"},"COG5152","pfam13923","zf-C3HC4_2","Zinc finger, C3HC4 type (RING finger).",".",".",".",".","."]
["ENSRNOG00000016717",22,1.826586532,72,4.631791549,0.394358535,-1.342420227,{"v":3.07637e-05,"d":"3.08E-05"},{"v":3.87828e-05,"d":"3.88E-05"},"down","yes","Gas2","protein_coding","chr1:101482591-101582619:+","gi|189011542|ref|NP_001120976.1|",1496,0,"growth arrest-specific protein 2 [Rattus norvegicus]","gi|189011541|ref|NM_001127504.1|",2056,0,"Rattus norvegicus growth arrest-specific 2 (Gas2), mRNA","P11862",578,0,"Growth arrest-specific protein 2",".",".",".",".","pfam02187","GAS2","Growth-Arrest-Specific Protein 2 Domain.","GO:0001544|initiation of primordial ovarian follicle growth;GO:0001547|antral ovarian follicle growth;GO:0006915|apoptotic process;GO:0008593|regulation of Notch signaling pathway;GO:0030728|ovulation;GO:0051764|actin crosslink formation;GO:0071711|basement membrane organization;","GO:0005884|actin filament;","GO:0008017|microtubule binding;GO:0008093|cytoskeletal adaptor activity;GO:0051015|actin filament binding;","K24627","GAS2, GAS2L; growth arrest-specific protein 2"]
["ENSRNOG00000051152",26,2.158693174,80,5.146435055,0.419454079,-1.253415221,{"v":3.10451e-05,"d":"3.10E-05"},{"v":3.91067e-05,"d":"3.91E-05"},"down","yes","ENSRNOG00000051152","protein_coding","chr7:7136861-7225513:-","gi|564307957|ref|XP_006225983.1|",696,{"v":1E-87,"d":"1.00E-87"},"PREDICTED: zinc finger protein 431-like isoform X3 [Rattus norvegicus]","gi|672057640|ref|XM_006240825.2|",786,0,"PREDICTED: Rattus norvegicus zinc finger protein 124-like (LOC102549817), transcript variant X4, mRNA","E9QAG8",101,{"v":5e-22,"d":"5.00E-22"},"Zinc finger protein 431",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006355|regulation of transcription, DNA-templated;",".",".",".","."]
["ENSRNOG00000017816",11,0.913293266,48,3.087861033,0.295768902,-1.757457726,{"v":3.38518E-5,"d":"3.39E-05"},{"v":4.24083e-05,"d":"4.24E-05"},"down","yes","Pde6a","protein_coding","chr18:54676863-54748816:+","gi|157817494|ref|NP_001100856.1|",4256,0,"rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha [Rattus norvegicus]","gi|157817493|ref|NM_001107386.1|",3292,0,"Rattus norvegicus phosphodiesterase 6A (Pde6a), mRNA","P27664",1630,0,"Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha",".",".",".",".","pfam00233","PDEase_I","3'5'-cyclic nucleotide phosphodiesterase.","GO:0007165|signal transduction;GO:0007601|visual perception;GO:0008150|biological_process;GO:0045494|photoreceptor cell maintenance;GO:0060041|retina development in camera-type eye;","GO:0005575|cellular_component;GO:0042622|photoreceptor outer segment membrane;","GO:0003674|molecular_function;GO:0004114|3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0046872|metal ion binding;GO:0047555|3',5'-cyclic-GMP phosphodiesterase activity;","K08718","PDE6A; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha [EC:3.1.4.35]"]
["ENSRNOG00000031290",3,0.249079982,27,1.736921831,0.143403104,-2.801851845,{"v":3.52555e-05,"d":"3.53E-05"},{"v":4.40202e-05,"d":"4.40E-05"},"down","yes","Trappc3l","protein_coding","chr20:25967502-26078989:+","gi|26324706|dbj|BAC26107.1|",922,{"v":1e-112,"d":"1.00E-112"},"unnamed protein product [Mus musculus]","gi|298913382|emb|FQ214407.1|",1026,0,"Rattus norvegicus TL0AAA41YN21 mRNA sequence","Q4KL14",343,{"v":3e-110,"d":"3.00E-110"},"Trafficking protein particle complex subunit 3-like protein",".",".",".",".","pfam14798","Ca_hom_mod","Calcium homeostasis modulator. This family of proteins control cytosolic calcium concentration. They are transmembrane proteins which may be pore-forming ion channels.","GO:0006888|ER to Golgi vesicle-mediated transport;GO:0006891|intra-Golgi vesicle-mediated transport;","GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;GO:0030008|TRAPP complex;GO:0033106|cis-Golgi network membrane;",".","K20302","TRAPPC3, BET3; trafficking protein particle complex subunit 3"]
["ENSRNOG00000052665",3,0.249079982,27,1.736921831,0.143403104,-2.801851845,{"v":3.52555e-05,"d":"3.53E-05"},{"v":4.40202e-05,"d":"4.40E-05"},"down","yes","Onecut2","protein_coding","chr18:57832111-57879629:+","gi|119220568|ref|NP_919244.2|",2066,0,"one cut domain family member 2 [Mus musculus]","gi|672083727|ref|XM_008772203.1|",2063,0,"PREDICTED: Rattus norvegicus one cut homeobox 2 (Onecut2), transcript variant X2, mRNA","Q6XBJ3",800,0,"One cut domain family member 2",".",".",".",".","pfam02376","CUT","CUT domain. The CUT domain is a DNA-binding motif which can bind independently or in cooperation with the homeodomain, often found downstream of the CUT domain. Multiple copies of the CUT domain can exist in one protein.","GO:0001889|liver development;GO:0001952|regulation of cell-matrix adhesion;GO:0002064|epithelial cell development;GO:0009653|anatomical structure morphogenesis;GO:0030335|positive regulation of cell migration;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0031016|pancreas development;GO:0031018|endocrine pancreas development;GO:0045165|cell fate commitment;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048935|peripheral nervous system neuron development;GO:0060271|cilium assembly;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0015629|actin cytoskeleton;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:1990837|sequence-specific double-stranded DNA binding;","K24170","ONECUT2; one cut domain family member 2"]
["ENSRNOG00000000138",4,0.332106642,30,1.929913146,0.172083725,-2.538817439,{"v":3.54603e-05,"d":"3.55E-05"},{"v":4.42499e-05,"d":"4.42E-05"},"down","yes","Glis1","protein_coding","chr5:122222128-122412141:+","gi|564305844|ref|XP_006225510.1|",3160,0,"PREDICTED: zinc finger protein GLIS1 [Rattus norvegicus]","gi|672019711|ref|XM_006225448.2|",2816,0,"PREDICTED: Rattus norvegicus GLIS family zinc finger 1 (Glis1), mRNA","Q8K1M4",1153,0,"Zinc finger protein GLIS1",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001649|osteoblast differentiation;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008150|biological_process;GO:0010454|negative regulation of cell fate commitment;GO:0045444|fat cell differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005575|cellular_component;GO:0005634|nucleus;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0046872|metal ion binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09232","GLIS1_3; zinc finger protein GLIS1/3"]
["ENSRNOG00000032208",32,2.656853137,91,5.854069875,0.453847186,-1.139721484,{"v":3.78519e-05,"d":"3.79E-05"},{"v":4.7069e-05,"d":"4.71E-05"},"down","yes","Eda","protein_coding","chrX:65078673-65480172:+","gi|765099177|ref|NP_001292172.1|",994,{"v":4e-118,"d":"4.00E-118"},"ectodysplasin-A [Rattus norvegicus]","gi|765099176|ref|NM_001305243.1|",4917,0,"Rattus norvegicus ectodysplasin-A (Eda), mRNA","O54693",325,{"v":3e-97,"d":"3.00E-97"},"Ectodysplasin-A",".",".",".",".","pfam00229","TNF","TNF(tumor Necrosis Factor) family.","GO:0001942|hair follicle development;GO:0006955|immune response;GO:0007160|cell-matrix adhesion;GO:0007165|signal transduction;GO:0008150|biological_process;GO:0010467|gene expression;GO:0010628|positive regulation of gene expression;GO:0019221|cytokine-mediated signaling pathway;GO:0042475|odontogenesis of dentin-containing tooth;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043473|pigmentation;GO:0043588|skin development;GO:0048513|animal organ development;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0060662|salivary gland cavitation;GO:0060789|hair follicle placode formation;GO:0061153|trachea gland development;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:1901222|regulation of NIK/NF-kappaB signaling;GO:1901224|positive regulation of NIK/NF-kappaB signaling;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005789|endoplasmic reticulum membrane;GO:0005811|lipid droplet;GO:0005887|integral component of plasma membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0045177|apical part of cell;","GO:0003674|molecular_function;GO:0005102|signaling receptor binding;GO:0005123|death receptor binding;GO:0005164|tumor necrosis factor receptor binding;GO:0038177|death receptor agonist activity;GO:0048018|receptor ligand activity;","K05480","EDA; ectodysplasin-A"]
["ENSRNOG00000063932",32,2.656853137,91,5.854069875,0.453847186,-1.139721484,{"v":3.78519e-05,"d":"3.79E-05"},{"v":4.7069e-05,"d":"4.71E-05"},"down","yes","ENSRNOG00000063932","lncRNA","chr4:30642554-30645588:+","gi|148680200|gb|EDL12147.1|",147,3e-08,"mCG145184, partial [Mus musculus]","gi|672048786|ref|XM_008762679.1|",3035,0,"PREDICTED: Rattus norvegicus cyclin-dependent kinase 6 (Cdk6), transcript variant X4, mRNA",".",".",".",".",".",".",".",".","pfam03025","Papilloma_E5","Papillomavirus E5. The E5 protein from papillomaviruses is about 80 amino acids long. The proteins are contain three regions that are predicted to be transmembrane alpha helices. The function of this protein is unknown.",".",".",".",".","."]
["ENSRNOG00000030048",12,0.996319926,50,3.216521909,0.309750704,-1.690820533,{"v":3.81831e-05,"d":"3.82E-05"},{"v":4.74625e-05,"d":"4.75E-05"},"down","yes","AABR07038355.1","protein_coding","chrX:43263490-43616852:-","gi|880971402|ref|XP_012981921.1|",7644,0,"PREDICTED: calponin homology domain-containing protein 2 [Mesocricetus auratus]","gi|672087576|ref|XM_006256978.2|",3633,0,"PREDICTED: Rattus norvegicus hypothetical protein LOC680813 (LOC680813), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam07948","Nairovirus_M","Nairovirus M polyprotein-like. The sequences in this family are similar to the Dugbe virus M polyprotein precursor, which includes glycoproteins G1 and G2. Both are thought to be inserted in the membrane of the Golgi complex of the infected host cell, and G1 is known to have a role in infection of vertebrate hosts.",".",".",".","K25552","CFAP47; cilia- and flagella-associated protein 47"]
["ENSRNOG00000046791",20,1.66053321,67,4.310139358,0.38526207,-1.376087939,{"v":4.18037e-05,"d":"4.18E-05"},{"v":5.17115e-05,"d":"5.17E-05"},"down","yes","Sh3rf3","protein_coding","chr20:26765015-27099257:+","gi|148700264|gb|EDL32211.1|",3624,0,"RIKEN cDNA 4831416G18, isoform CRA_b, partial [Mus musculus]","gi|672031765|ref|XM_008774966.1|",2412,0,"PREDICTED: Rattus norvegicus SH3 domain containing ring finger 3 (Sh3rf3), mRNA","Q8C120",1399,0,"SH3 domain-containing RING finger protein 3",".",".",".",".","pfam14604","SH3_9","Variant SH3 domain.","GO:0006915|apoptotic process;GO:0046330|positive regulation of JNK cascade;GO:0051865|protein autoubiquitination;",".","GO:0061630|ubiquitin protein ligase activity;","K12171","SH3RF, POSH; E3 ubiquitin-protein ligase SH3RF [EC:2.3.2.27]"]
["ENSRNOG00000069967",6,0.498159963,35,2.251565336,0.221250503,-2.17624736,{"v":4.56296e-05,"d":"4.56E-05"},{"v":5.62803e-05,"d":"5.63E-05"},"down","yes","Sumo4","protein_coding","chr5:15099419-15099706:+","gi|293359129|ref|XP_002729504.1|",507,{"v":2e-64,"d":"2.00E-64"},"PREDICTED: small ubiquitin-related modifier 2 [Rattus norvegicus]","gi|672052018|ref|XM_002729458.4|",288,{"v":6E-148,"d":"6.00E-148"},"PREDICTED: Rattus norvegicus SMT3 suppressor of mif two 3 homolog 2-like (Sumo2l), mRNA","P61959",192,{"v":5e-63,"d":"5.00E-63"},"Small ubiquitin-related modifier 2","SPBC365.06",89.4,{"v":7e-23,"d":"7.00E-23"},"COG5227","pfam11976","Rad60-SLD","Ubiquitin-2 like Rad60 SUMO-like. The small ubiquitin-related modifier SUMO-1 is a Ub/Ubl family member, and although SUMO-1 shares structural similarity to Ub, SUMO's cellular functions remain distinct insomuch as SUMO modification alters protein function through changes in activity, cellular localisation, or by protecting substrates from ubiquitination. Rad60 family members contain functionally enigmatic, integral SUMO-like domains (SLDs). Despite their divergence from SUMO, each Rad60 SLD interacts with a subset of SUMO pathway enzymes: SLD2 specifically binds the SUMO E2 conjugating enzyme (Ubc9)), whereas SLD1 binds the SUMO E1 (Fub2, also called Uba2) activating and E3 (Pli1, also called Siz1 and Siz2) specificity enzymes. Structural analysis of PDB:2uyz reveals a mechanistic basis for the near-synonymous roles of Rad60 and SUMO in survival of genotoxic stress and suggest unprecedented DNA-damage-response functions for SLDs in regulating SUMOylation. The Rad60 branch of this family is also known as RENi (Rad60-Esc2-Nip45), and biologically it should be two distinct families SUMO and RENi (Rad60-Esc2-Nip45).",".",".",".",".","."]
["ENSRNOG00000063759",2,0.166053321,23,1.479600078,0.112228516,-3.1554888,{"v":5.25103e-05,"d":"5.25E-05"},{"v":6.41001e-05,"d":"6.41E-05"},"down","yes","ENSRNOG00000063759","lncRNA","chr9:106024644-106026682:-","gi|56789200|gb|AAH88270.1|",147,5e-08,"Wash2 protein [Rattus norvegicus]","gi|672033602|ref|XM_008758262.1|",553,0,"PREDICTED: Rattus norvegicus WAS protein family homolog (Wash), transcript variant X1, mRNA","Q8VDD8",60.5,2E-8,"WASH complex subunit 1",".",".",".",".","pfam15557","CAF1-p150_N","CAF1 complex subunit p150, region binding to PCNA. CAF1-p150_N is part of the N-terminus of the CAF1 complex p150 subunit that binds to PCNA - proliferating cell nuclear antigen. The PCNA mediates the connection between CAF-1 and the DNA replication fork. The CAF1 complex is essential in human cells for the de novo deposition of histones H3 and H4 at the DNA replication fork.",".",".",".",".","."]
["ENSRNOG00000023230",38,3.1550131,101,6.497374257,0.485582787,-1.042210813,{"v":5.41465e-05,"d":"5.41E-05"},{"v":6.59464e-05,"d":"6.59E-05"},"down","yes","RGD1307621","protein_coding","chr6:82965328-82972558:+","gi|157820079|ref|NP_001101495.1|",1671,0,"uncharacterized protein C14orf28 homolog [Rattus norvegicus]","gi|157820078|ref|NM_001108025.1|",1185,0,"Rattus norvegicus hypothetical LOC314168 (RGD1307621), mRNA",".",".",".",".",".",".",".",".","pfam05997","Nop52","Nucleolar protein,Nop52. Nop52 believed to be involved in the generation of 28S rRNA.",".",".",".",".","."]
["ENSRNOG00000046390",18,1.494479889,62,3.988487167,0.374698432,-1.416198153,{"v":5.6201e-05,"d":"5.62E-05"},{"v":6.82924e-05,"d":"6.83E-05"},"down","yes","Tceal3","protein_coding","chrX:100010690-100012654:+","gi|148691879|gb|EDL23826.1|",628,{"v":9e-77,"d":"9.00E-77"},"mCG114170, isoform CRA_a, partial [Mus musculus]","gi|672088353|ref|XM_577026.6|",1080,0,"PREDICTED: Rattus norvegicus transcription elongation factor A (SII)-like 3 (Tceal3), mRNA","Q8R0A5",224,{"v":4E-70,"d":"4.00E-70"},"Transcription elongation factor A protein-like 3",".",".",".",".","pfam04538","BEX","Brain expressed X-linked like family. This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.",".","GO:0005634|nucleus;","GO:0050699|WW domain binding;",".","."]
["ENSRNOG00000065699",37,3.071986439,99,6.36871338,0.482355895,-1.051830098,{"v":5.65005e-05,"d":"5.65E-05"},{"v":6.86043e-05,"d":"6.86E-05"},"down","yes","ENSRNOG00000065699","protein_coding","chr14:100606613-100607588:+","gi|913513001|ref|XP_013208915.1|",1103,{"v":4e-147,"d":"4.00E-147"},"PREDICTED: 60 kDa heat shock protein, mitochondrial [Microtus ochrogaster]","gi|302318920|ref|NG_023470.1|",638,0,"Rattus norvegicus heat shock protein 1, pseudogene 1 (Hspd1-ps1) on chromosome 14","P63039",430,{"v":2e-147,"d":"2.00E-147"},"60 kDa heat shock protein, mitochondrial","SPAC12G12.04",280,{"v":2e-89,"d":"2.00E-89"},"COG0459","pfam00118","Cpn60_TCP1","TCP-1/cpn60 chaperonin family. This family includes members from the HSP60 chaperone family and the TCP-1 (T-complex protein) family.",".",".",".",".","."]
["ENSRNOG00000049446",26,2.158693174,78,5.017774178,0.430209311,-1.216889345,{"v":5.85071e-05,"d":"5.85E-05"},{"v":7.08658e-05,"d":"7.09E-05"},"down","yes","ENSRNOG00000049446","protein_coding","chr14:4869196-4938277:-","gi|295444960|ref|NP_001171380.1|",394,{"v":1e-44,"d":"1.00E-44"},"rCG37858-like [Rattus norvegicus]","gi|295444959|ref|NM_001177909.1|",313,{"v":3e-161,"d":"3.00E-161"},"Rattus norvegicus rCG37858-like (LOC100366030), mRNA","E9QAG8",106,{"v":3E-24,"d":"3.00E-24"},"Zinc finger protein 431",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006355|regulation of transcription, DNA-templated;",".",".",".","."]
["ENSRNOG00000047967",20,1.66053321,66,4.24580892,0.391099374,-1.354392868,{"v":5.88066E-5,"d":"5.88E-05"},{"v":7.12016e-05,"d":"7.12E-05"},"down","yes","Arhgef19","protein_coding","chr5:153536013-153554203:+","gi|157822717|ref|NP_001102162.1|",4179,0,"rho guanine nucleotide exchange factor 19 [Rattus norvegicus]","gi|157822716|ref|NM_001108692.1|",3648,0,"Rattus norvegicus Rho guanine nucleotide exchange factor 19 (Arhgef19), mRNA","Q8BWA8",1387,0,"Rho guanine nucleotide exchange factor 19","SPCC645.07",72.8,{"v":5e-12,"d":"5.00E-12"},"COG5422","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0032956|regulation of actin cytoskeleton organization;GO:0042060|wound healing;GO:0043547|positive regulation of GTPase activity;GO:0090630|activation of GTPase activity;",".","GO:0005085|guanyl-nucleotide exchange factor activity;","K20691","ARHGEF19, WGEF; Rho guanine nucleotide exchange factor 19"]
["ENSRNOG00000010158",7,0.581186624,37,2.380226213,0.244172852,-2.034025287,{"v":5.92864e-05,"d":"5.93E-05"},{"v":7.17418e-05,"d":"7.17E-05"},"down","yes","Magel2","protein_coding","chr1:115880474-115884250:+","gi|392344312|ref|XP_001054803.2|",4326,0,"PREDICTED: MAGE-like protein 2 [Rattus norvegicus]","gi|672013777|ref|XM_002725637.4|",3777,0,"PREDICTED: Rattus norvegicus MAGE-like 2 (Magel2), mRNA","Q9QZ04",1477,0,"MAGE-like protein 2",".",".",".",".","pfam01454","MAGE","MAGE family. The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumors but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0034314|Arp2/3 complex-mediated actin nucleation;GO:0042147|retrograde transport, endosome to Golgi;GO:0042752|regulation of circadian rhythm;GO:0045892|negative regulation of transcription, DNA-templated;GO:0051127|positive regulation of actin nucleation;GO:0070534|protein K63-linked ubiquitination;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005829|cytosol;GO:0030904|retromer complex;","GO:0004842|ubiquitin-protein transferase activity;","K23950","MAGEL2; MAGE-like protein 2"]
["ENSRNOG00000001092",22,1.826586532,70,4.503130673,0.405625922,-1.301778242,{"v":5.99023e-05,"d":"5.99E-05"},{"v":7.24459e-05,"d":"7.24E-05"},"down","yes","Kl","protein_coding","chr12:490399-530080:+","gi|13786168|ref|NP_112626.1|",4910,0,"klotho precursor [Rattus norvegicus]","gi|13786167|ref|NM_031336.1|",3500,0,"Rattus norvegicus Klotho (Kl), mRNA","Q9Z2Y9",1897,0,"Klotho","BH1923",198,{"v":1E-53,"d":"1.00E-53"},"COG2723","pfam00232","Glyco_hydro_1","Glycosyl hydrolase family 1.","GO:0002526|acute inflammatory response;GO:0003085|negative regulation of systemic arterial blood pressure;GO:0005975|carbohydrate metabolic process;GO:0006112|energy reserve metabolic process;GO:0007568|aging;GO:0008286|insulin receptor signaling pathway;GO:0008543|fibroblast growth factor receptor signaling pathway;GO:0014823|response to activity;GO:0030501|positive regulation of bone mineralization;GO:0033280|response to vitamin D;GO:0042421|norepinephrine biosynthetic process;GO:0055074|calcium ion homeostasis;GO:0071774|response to fibroblast growth factor;GO:0090080|positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway;GO:1990776|response to angiotensin;","GO:0005615|extracellular space;GO:0005783|endoplasmic reticulum;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;","GO:0004553|hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0004566|beta-glucuronidase activity;GO:0005104|fibroblast growth factor receptor binding;GO:0008422|beta-glucosidase activity;GO:0017134|fibroblast growth factor binding;","K14756","KL; klotho [EC:3.2.1.31]"]
["ENSRNOG00000065376",23,1.909613192,72,4.631791549,0.412283923,-1.278289889,{"v":5.99557e-05,"d":"6.00E-05"},{"v":7.2483e-05,"d":"7.25E-05"},"down","yes","ENSRNOG00000065376","lncRNA","chr3:156392971-156394687:-",".",".",".",".","gi|31616713|emb|AL935060.17|",197,{"v":2e-96,"d":"2.00E-96"},"Mouse DNA sequence from clone RP24-151H6 on chromosome 2, complete sequence",".",".",".",".",".",".",".",".","pfam02948","Amelogenin","Amelogenin. Amelogenins play a role in biomineralisation. They seem to regulate the formation of crystallites during the secretory stage of tooth enamel development. thought to play a major role in the structural organisation and mineralisation of developing enamel. They are found in the extracellular matrix. Mutations in X-chromosomal amelogenin can cause Amelogenesis imperfecta.",".",".",".",".","."]
["ENSRNOG00000018003",35,2.905933118,95,6.111391628,0.475494502,-1.072499435,{"v":6.12575e-05,"d":"6.13E-05"},{"v":7.39171e-05,"d":"7.39E-05"},"down","yes","F2rl1","protein_coding","chr2:26772278-26785226:-","gi|16758770|ref|NP_446349.1|",1962,0,"proteinase-activated receptor 2 precursor [Rattus norvegicus]","gi|71534284|ref|NM_053897.2|",2952,0,"Rattus norvegicus F2R like trypsin receptor 1 (F2rl1), mRNA","Q63645",760,0,"Proteinase-activated receptor 2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0002286|T cell activation involved in immune response;GO:0002690|positive regulation of leukocyte chemotaxis;GO:0002720|positive regulation of cytokine production involved in immune response;GO:0003104|positive regulation of glomerular filtration;GO:0006954|inflammatory response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007596|blood coagulation;GO:0009306|protein secretion;GO:0010804|negative regulation of tumor necrosis factor-mediated signaling pathway;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0030193|regulation of blood coagulation;GO:0030335|positive regulation of cell migration;GO:0030836|positive regulation of actin filament depolymerization;GO:0031274|positive regulation of pseudopodium assembly;GO:0032682|negative regulation of chemokine production;GO:0032722|positive regulation of chemokine production;GO:0032729|positive regulation of interferon-gamma production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032733|positive regulation of interleukin-10 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0032930|positive regulation of superoxide anion generation;GO:0034137|positive regulation of toll-like receptor 2 signaling pathway;GO:0034140|negative regulation of toll-like receptor 3 signaling pathway;GO:0034141|positive regulation of toll-like receptor 3 signaling pathway;GO:0034145|positive regulation of toll-like receptor 4 signaling pathway;GO:0035025|positive regulation of Rho protein signal transduction;GO:0042119|neutrophil activation;GO:0042311|vasodilation;GO:0043122|regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043311|positive regulation of eosinophil degranulation;GO:0043547|positive regulation of GTPase activity;GO:0045087|innate immune response;GO:0045217|cell-cell junction maintenance;GO:0045907|positive regulation of vasoconstriction;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046328|regulation of JNK cascade;GO:0046329|negative regulation of JNK cascade;GO:0046330|positive regulation of JNK cascade;GO:0050900|leukocyte migration;GO:0050921|positive regulation of chemotaxis;GO:0050927|positive regulation of positive chemotaxis;GO:0051482|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway;GO:0051607|defense response to virus;GO:0060100|positive regulation of phagocytosis, engulfment;GO:0061028|establishment of endothelial barrier;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070493|thrombin-activated receptor signaling pathway;GO:0070661|leukocyte proliferation;GO:0070963|positive regulation of neutrophil mediated killing of gram-negative bacterium;GO:0097029|mature conventional dendritic cell differentiation;GO:1900135|positive regulation of renin secretion into blood stream;GO:2000341|regulation of chemokine (C-X-C motif) ligand 2 production;","GO:0005769|early endosome;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0031143|pseudopodium;","GO:0001965|G-protein alpha-subunit binding;GO:0004930|G protein-coupled receptor activity;GO:0005515|protein binding;GO:0015057|thrombin-activated receptor activity;GO:0031681|G-protein beta-subunit binding;","K04234","F2RL1, PAR2; coagulation factor II (thrombin) receptor-like 1"]
["ENSRNOG00000018792",0,0.04151333,17,1.093617449,0.037959645,-4.719389685,{"v":7.31998e-05,"d":"7.32E-05"},{"v":8.73548e-05,"d":"8.74E-05"},"down","yes","Tekt4","protein_coding","chr10:14487760-14492936:+","gi|62078659|ref|NP_001013987.1|",2347,0,"tektin-4 [Rattus norvegicus]","gi|62078658|ref|NM_001013965.1|",1515,0,"Rattus norvegicus tektin 4 (Tekt4), mRNA","Q6AXV2",908,0,"Tektin-4",".",".",".",".","pfam03148","Tektin","Tektin family. Tektins are cytoskeletal proteins. They have been demonstrated in such cellular sites as centrioles, basal bodies, and along ciliary and flagellar doublet microtubules. Tektins form unique protofilaments, organized as longitudinal polymers of tektin heterodimers with axial periodicity matching tubulin. Tektin polypeptides consist of several alpha-helical regions that are predicted to form coiled coils. Indeed, tektins share considerable structural similarities with intermediate filament proteins. Possible functional roles for tektins are: stabilisation of tubulin protofilaments; attachment of A and B-tubules in ciliary/flagellar microtubule doublets and C-tubules in centrioles; binding of axonemal components.","GO:0060271|cilium assembly;GO:0060294|cilium movement involved in cell motility;GO:0060378|regulation of brood size;","GO:0015630|microtubule cytoskeleton;GO:0036126|sperm flagellum;GO:0097225|sperm midpiece;GO:0097228|sperm principal piece;",".","K18631","TEKT4; tektin-4"]
["ENSRNOG00000064667",0,0.04151333,17,1.093617449,0.037959645,-4.719389685,{"v":7.31998e-05,"d":"7.32E-05"},{"v":8.73548e-05,"d":"8.74E-05"},"down","yes","Tmem86b","pseudogene","chr1:69218608-69220124:+","gi|564326271|ref|XP_006228351.1|",882,{"v":5E-117,"d":"5.00E-117"},"PREDICTED: lysoplasmalogenase isoform X1 [Rattus norvegicus]","gi|672035218|ref|XM_006228289.2|",591,0,"PREDICTED: Rattus norvegicus transmembrane protein 86B (Tmem86b), transcript variant X1, mRNA","B0BNF0",344,{"v":2E-118,"d":"2.00E-118"},"Lysoplasmalogenase",".",".",".",".","pfam07947","YhhN","YhhN-like protein. The members of this family are similar to the hypothetical protein yhhN expressed by Escherichia coli. Many of the members of this family are annotated as being possible transmembrane proteins, and in fact they all have a high proportion of hydrophobic residues.",".",".",".",".","."]
["ENSRNOG00000066982",0,0.04151333,17,1.093617449,0.037959645,-4.719389685,{"v":7.31998e-05,"d":"7.32E-05"},{"v":8.73548e-05,"d":"8.74E-05"},"down","yes","ENSRNOG00000066982","protein_coding","chr9:113729880-113776907:+","gi|672018981|ref|XP_008774104.1|",2302,0,"PREDICTED: zinc finger protein 431-like isoform X1 [Rattus norvegicus]","gi|672018984|ref|XR_600914.1|",1686,0,"PREDICTED: Rattus norvegicus zinc finger protein 120-like (LOC102557117), misc_RNA","E9QAG8",669,0,"Zinc finger protein 431",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000011646",16,1.328426568,57,3.666834977,0.362281525,-1.464816858,{"v":7.44937e-05,"d":"7.45E-05"},{"v":8.88657e-05,"d":"8.89E-05"},"down","yes","Rem2","protein_coding","chr15:27933950-27938429:+","gi|259490277|ref|NP_073176.2|",1503,0,"GTP-binding protein REM 2 [Rattus norvegicus]","gi|259490276|ref|NM_022685.2|",1810,0,"Rattus norvegicus RAS (RAD and GEM) like GTP binding 2 (Rem2), mRNA","Q9WTY2",583,0,"GTP-binding protein REM 2","SPAC17H9.09c",85.5,{"v":1e-17,"d":"1.00E-17"},"COG1100","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.",".","GO:0005886|plasma membrane;GO:0016020|membrane;","GO:0003924|GTPase activity;GO:0005246|calcium channel regulator activity;GO:0005525|GTP binding;","K07848","REM2; Rad and Gem related GTP binding protein 2"]
["ENSRNOG00000063398",11,0.913293266,46,2.959200157,0.308628419,-1.696057181,{"v":7.53635e-05,"d":"7.54E-05"},{"v":8.98196e-05,"d":"8.98E-05"},"down","yes","Nat8","protein_coding","chr4:118270954-118281763:-","gi|12018332|ref|NP_072157.1|",976,{"v":2E-116,"d":"2.00E-116"},"N-acetyltransferase 8 [Rattus norvegicus]","gi|746817484|ref|NR_130141.1|",1450,0,"Rattus norvegicus uncharacterized LOC100910827 (LOC100910827), long non-coding RNA","Q9QXT3",380,{"v":5e-118,"d":"5.00E-118"},"N-acetyltransferase 8",".",".",".",".","pfam00583","Acetyltransf_1","Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.",".",".",".",".","."]
["ENSRNOG00000067218",17,1.411453229,59,3.795495853,0.371875845,-1.427107052,{"v":7.73893e-05,"d":"7.74E-05"},{"v":9.20346e-05,"d":"9.20E-05"},"down","yes","ENSRNOG00000067218","lncRNA","chr1:205619695-205622491:-","gi|149062285|gb|EDM12708.1|",247,{"v":3E-23,"d":"3.00E-23"},"rCG47316, isoform CRA_d [Rattus norvegicus]","gi|672014639|ref|XR_599158.1|",845,0,"PREDICTED: Rattus norvegicus uncharacterized LOC100912041 (LOC100912041), transcript variant X9, ncRNA",".",".",".",".",".",".",".",".","pfam11046","HycA_repressor","Transcriptional repressor of hyc and hyp operons. This family is conserved in Proteobacteria. It is likely to be the transcriptional repressor molecule for the hyc and hyp operons, which express, amongst others, the protein HycA. This protein may be harnessed for the reduction of technetium oxide, an unwelcome product of radio-nucleotide bioaccumulation. HycA produces formate hydrogenlyase, one of the key proteins necessary for metal compound reduction.",".",".",".",".","."]
["ENSRNOG00000031378",25,2.075666513,75,4.824782864,0.430209311,-1.216889345,{"v":8.12405e-05,"d":"8.12E-05"},{"v":9.62498e-05,"d":"9.62E-05"},"down","yes","AABR07009715.1","protein_coding","chr2:104591786-104592794:+","gi|67078426|ref|NP_001019967.1|",1305,{"v":5e-180,"d":"5.00E-180"},"spindlin-1 [Rattus norvegicus]","gi|672042019|ref|XR_591014.1|",752,0,"PREDICTED: Rattus norvegicus similar to spindlin (LOC682571), transcript variant X2, misc_RNA","Q4V8J7",507,0,"Spindlin-1",".",".",".",".","pfam02513","Spin-Ssty","Spin/Ssty Family. Spindlin (Spin) is a novel maternal transcript present in the unfertilised egg and early embryo. The Y-linked spermiogenesis -specific transcript (Ssty) is also expressed during gametogenesis and forms part of this Pfam family. Members of this family contain three copies of this 50 residue repeat. The repeat is predicted to contain four beta strands.",".",".",".",".","."]
["ENSRNOG00000020072",9,0.747239945,41,2.637547966,0.283308571,-1.819553847,{"v":8.68776e-05,"d":"8.69E-05"},1.02416E-4,"down","yes","Pcdhb9","protein_coding","chr18:29105298-29108468:+","gi|157820663|ref|NP_001102860.1|",4117,0,"protocadherin beta 9 [Rattus norvegicus]","gi|157820662|ref|NM_001109390.1|",3171,0,"Rattus norvegicus protocadherin beta 9 (Pcdhb9), mRNA","Q5DRD0",1229,0,"Protocadherin beta-4",".",".",".",".","pfam08266","Cadherin_2","Cadherin-like. This cadherin domain is usually the most N-terminal copy of the domain.","GO:0007155|cell adhesion;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;","GO:0005887|integral component of plasma membrane;","GO:0005509|calcium ion binding;","K16494","PCDHB; protocadherin beta"]
["ENSRNOG00000015903",2,0.166053321,22,1.41526964,0.117329812,-3.091358462,{"v":8.92176e-05,"d":"8.92E-05"},1.04942E-4,"down","yes","Add2","protein_coding","chr4:118497416-118538505:+","gi|6978449|ref|NP_036623.1|",3051,0,"beta-adducin isoform b [Rattus norvegicus]","gi|158081760|ref|NM_012491.2|",3251,0,"Rattus norvegicus adducin 2 (Add2), transcript variant 2, mRNA","Q9QYB8",1123,0,"Beta-adducin","CC1201",144,{"v":1e-36,"d":"1.00E-36"},"COG0235","pfam00596","Aldolase_II","Class II Aldolase and Adducin N-terminal domain. This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.","GO:0006811|ion transport;GO:0007416|synapse assembly;GO:0030097|hemopoiesis;GO:0032092|positive regulation of protein binding;GO:0050900|leukocyte migration;GO:0050901|leukocyte tethering or rolling;GO:0051016|barbed-end actin filament capping;GO:0051017|actin filament bundle assembly;GO:0065003|protein-containing complex assembly;","GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0008290|F-actin capping protein complex;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0031410|cytoplasmic vesicle;GO:0044853|plasma membrane raft;GO:0098794|postsynapse;GO:0098978|glutamatergic synapse;","GO:0003779|actin binding;GO:0005200|structural constituent of cytoskeleton;GO:0005516|calmodulin binding;GO:0019901|protein kinase binding;GO:0030507|spectrin binding;GO:0042803|protein homodimerization activity;GO:0046982|protein heterodimerization activity;GO:0051015|actin filament binding;","K18622","ADD; adducin"]
["ENSRNOG00000070972",4,0.332106642,28,1.801252269,0.184375419,-2.439281766,{"v":9.41621e-05,"d":"9.42E-05"},1.10332E-4,"down","yes","ENSRNOG00000070972","protein_coding","chr15:4625982-4688858:-","gi|564385445|ref|XP_006251744.1|",1093,{"v":3e-145,"d":"3.00E-145"},"PREDICTED: uncharacterized protein LOC102547093 isoform X2 [Rattus norvegicus]","gi|672028263|ref|XM_006221886.2|",1096,0,"PREDICTED: Rattus norvegicus disks large homolog 5-like (LOC102547212), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam04822","Takusan","Takusan. This domain is named takusan, which is a Japanese word meaning 'many'. Members of this family regulate synaptic activity.",".",".",".",".","."]
["ENSRNOG00000005888",37,3.071986439,97,6.240052504,0.492301377,-1.02238632,{"v":9.84739e-05,"d":"9.85E-05"},0.000115131,"down","yes","Fsip1","protein_coding","chr3:105068543-105217167:-","gi|568918400|ref|XP_006500238.1|",2256,0,"PREDICTED: fibrous sheath-interacting protein 1 isoform X1 [Mus musculus]","gi|672017174|ref|XM_008775475.1|",1772,0,"PREDICTED: Rattus norvegicus fibrous sheath-interacting protein 1-like (LOC103691868), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam15554","FSIP1","FSIP1 family.",".",".",".",".","."]
["ENSRNOG00000042658",27,2.241719834,78,5.017774178,0.446755823,-1.162441561,0.000106479,0.000123686,"down","yes","Nxnl1","protein_coding","chr16:18262688-18279987:-","gi|404501522|ref|NP_001258270.1|",1085,{"v":3e-142,"d":"3.00E-142"},"nucleoredoxin-like protein 1 [Rattus norvegicus]","gi|672079662|ref|XM_006252894.2|",1212,0,"PREDICTED: Rattus norvegicus nucleoredoxin-like 1 (Nxnl1), transcript variant X3, mRNA","Q8VC33",395,{"v":6e-133,"d":"6.00E-133"},"Nucleoredoxin-like protein 1",".",".",".",".","pfam13905","Thioredoxin_8","Thioredoxin-like. Thioredoxins are small enzymes that participate in redox reactions, via the reversible oxidation of an active centre disulfide bond.","GO:0045494|photoreceptor cell maintenance;",".",".",".","."]
["ENSRNOG00000058148",16,1.328426568,56,3.602504538,0.368750838,-1.439281766,1.06531E-4,0.000123691,"down","yes","SNORD58","snoRNA","chr18:68581864-68581929:+",".",".",".",".","gi|908663701|tpe|LN872873.1|",54,{"v":1e-18,"d":"1.00E-18"},"TPA: Mus musculus SNORD58 gene for small nucleolar RNA SNORD58",".",".",".",".",".",".",".",".","pfam05787","DUF839","Bacterial protein of unknown function (DUF839). This family consists of several bacterial proteins of unknown function that contain a predicted beta-propeller repeats.",".",".",".",".","."]
["ENSRNOG00000004484",17,1.411453229,58,3.731165415,0.378287498,-1.402444998,1.09966E-4,1.27379E-4,"down","yes","Commd5","protein_coding","chr7:108598673-108624764:+","gi|564360784|ref|XP_006241977.1|",1151,{"v":4e-145,"d":"4.00E-145"},"PREDICTED: COMM domain-containing protein 5 [Rattus norvegicus]","gi|672059684|ref|XM_006241916.2|",1611,0,"PREDICTED: Rattus norvegicus COMM domain-containing protein 5-like (LOC100910472), transcript variant X2, mRNA","Q9ERR2",442,{"v":1e-144,"d":"1.00E-144"},"COMM domain-containing protein 5",".",".",".",".","pfam07258","HCaRG","HCaRG protein. This family consists of several mammalian HCaRG(hypertension-related, calcium-regulated gene) proteins. HCaRG is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals. HCaRG is a nuclear protein potentially involved in the control of cell proliferation.","GO:0030307|positive regulation of cell growth;GO:0030858|positive regulation of epithelial cell differentiation;GO:0051726|regulation of cell cycle;GO:0072158|proximal tubule morphogenesis;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;",".","K22561","COMMD5, HCARG; COMM domain containing 5"]
["ENSRNOG00000027831",25,2.075666513,74,4.760452426,0.436022951,-1.19752402,1.11086E-4,0.000128537,"down","yes","Map7d3","protein_coding","chrX:134619227-134685841:-","gi|672089029|ref|XP_008771871.1|",3831,0,"PREDICTED: MAP7 domain-containing protein 3 isoform X1 [Rattus norvegicus]","gi|404501490|ref|NM_001271327.1|",2867,0,"Rattus norvegicus MAP7 domain containing 3 (Map7d3), mRNA","A2AEY4",972,0,"MAP7 domain-containing protein 3",".",".",".",".","pfam05672","MAP7","MAP7 (E-MAP-115) family. The organisation of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilizing protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.","GO:0000226|microtubule cytoskeleton organization;GO:0046785|microtubule polymerization;","GO:0015630|microtubule cytoskeleton;","GO:0008017|microtubule binding;GO:0015631|tubulin binding;","K16807","MAP7D3; MAP7 domain-containing protein 3"]
["ENSRNOG00000049615",11,0.913293266,45,2.894869718,0.315486828,-1.664348322,0.000111825,0.000129322,"down","yes","Fam228b","protein_coding","chr6:27754506-27786537:-","gi|672020486|ref|XP_008774422.1|",1649,0,"PREDICTED: protein FAM228B isoform X1 [Rattus norvegicus]","gi|672055674|ref|XM_008764562.1|",1234,0,"PREDICTED: Rattus norvegicus family with sequence similarity 228, member B (Fam228b), transcript variant X7, mRNA",".",".",".",".",".",".",".",".","pfam02487","CLN3","CLN3 protein. This is a family of proteins from the CLN3 gene. A missense mutation of glutamic acid (E) to lysine (K) at position 295 in the human protein has been implicated in Juvenile neuronal ceroid lipofuscinosis (Batten disease).",".",".",".",".","."]
["ENSRNOG00000029841",1,0.083026661,18,1.157947887,0.071701552,-3.801851845,1.16313E-4,1.34148E-4,"down","yes","Cdh19","protein_coding","chr13:27936668-28019310:-","gi|57222296|ref|NP_001009448.1|",3818,0,"cadherin-19 precursor [Rattus norvegicus]","gi|672073793|ref|XM_006249653.2|",1754,0,"PREDICTED: Rattus norvegicus cadherin 19, type 2 (Cdh19), transcript variant X1, mRNA","Q9H159",1132,0,"Cadherin-19",".",".",".",".","pfam01049","Cadherin_C","Cadherin cytoplasmic region. Cadherins are vital in cell-cell adhesion during tissue differentiation. Cadherins are linked to the cytoskeleton by catenins. Catenins bind to the cytoplasmic tail of the cadherin. Cadherins cluster to form foci of homophilic binding units. A key determinant to the strength of the binding that it is mediated by cadherins is the juxtamembrane region of the cadherin. This region induces clustering and also binds to the protein p120ctn.","GO:0000902|cell morphogenesis;GO:0007043|cell-cell junction assembly;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007275|multicellular organism development;GO:0016339|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0034332|adherens junction organization;GO:0098742|cell-cell adhesion via plasma-membrane adhesion molecules;","GO:0005912|adherens junction;GO:0016021|integral component of membrane;GO:0016342|catenin complex;","GO:0005509|calcium ion binding;GO:0045296|cadherin binding;","K06806","CDH19; cadherin 19, type 2"]
["ENSRNOG00000063221",1,0.083026661,18,1.157947887,0.071701552,-3.801851845,1.16313E-4,1.34148E-4,"down","yes","Ncoa4","protein_coding","chr16:7366542-7409641:+","gi|564387996|ref|XP_006252722.1|",3153,0,"PREDICTED: nuclear receptor coactivator 4 isoform X1 [Rattus norvegicus]","gi|77628144|ref|NM_001034008.1|",3325,0,"Rattus norvegicus nuclear receptor coactivator 4 (Ncoa4), transcript variant 2, mRNA","Q13772",903,0,"Nuclear receptor coactivator 4",".",".",".",".","pfam12489","ARA70","Nuclear coactivator. This domain family is found in eukaryotes, and is typically between 127 and 138 amino acids in length. This family is ARA70, a nuclear coactivator which interacts with peroxisome proliferator-activated receptor gamma (PPARgamma) to regulate transcription and the addition of the PPARgamma ligand (prostaglandin J2) enhances this interaction.",".",".",".",".","."]
["ENSRNOG00000063848",1,0.083026661,18,1.157947887,0.071701552,-3.801851845,1.16313E-4,1.34148E-4,"down","yes","ENSRNOG00000063848","protein_coding","chr9:74231751-74237923:-","gi|672027568|ref|XP_008762237.1|",1460,0,"PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC102547825 isoform X1, partial [Rattus norvegicus]","gi|388240416|dbj|AP012456.1|",2704,0,"Rattus norvegicus DNA, BAC clone: RNB1-385K15, strain: F344/Stm, complete sequence","P03355",439,0,"Gag-Pol polyprotein",".",".",".",".","pfam02093","Gag_p30","Gag P30 core shell protein. According to Swiss-Prot annotation this protein is the viral core shell protein. P30 is essential for viral assembly.",".",".",".",".","."]
["ENSRNOG00000068010",12,0.996319926,47,3.023530595,0.329522026,-1.601553195,0.00012258,0.000140918,"down","yes","Myh8","protein_coding","chr10:51963510-51993232:+","gi|281604096|ref|NP_001093955.1|",9288,0,"myosin-8 [Rattus norvegicus]","gi|281604095|ref|NM_001100485.1|",6026,0,"Rattus norvegicus myosin, heavy chain 8, skeletal muscle, perinatal (Myh8), mRNA","P13542",3559,0,"Myosin-8","SPCC645.05c",747,0,"COG5022","pfam01576","Myosin_tail_1","Myosin tail. The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.",".",".",".",".","."]
["ENSRNOG00000033202",0,0.04151333,16,1.029287011,0.040332123,-4.631926844,0.000126282,1.44888E-4,"down","yes","Fbxo41","protein_coding","chr4:118010978-118039406:-","gi|296482725|tpg|DAA24840.1|",3424,0,"TPA: F-box protein 41-like [Bos taurus]","gi|157823332|ref|NM_001107871.1|",3107,0,"Rattus norvegicus F-box protein 41 (Fbxo41), mRNA","Q6NS60",1315,0,"F-box only protein 41",".",".",".",".","pfam12937","F-box-like","F-box-like. This is an F-box-like family.",".",".",".","K10316","FBXO41; F-box protein 41"]
["ENSRNOG00000069069",10,0.830266605,42,2.701878404,0.307292365,-1.702316172,1.4914E-4,0.000168692,"down","yes","ENSRNOG00000069069","protein_coding","chr19:9343901-9344893:-","gi|564394448|ref|XP_006255132.1|",218,{"v":2E-19,"d":"2.00E-19"},"PREDICTED: N-lysine methyltransferase SETD6 isoform X1 [Rattus norvegicus]","gi|672084057|ref|XM_006255070.2|",136,{"v":1e-63,"d":"1.00E-63"},"PREDICTED: Rattus norvegicus SET domain containing 6 (Setd6), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam06097","DUF945","Bacterial protein of unknown function (DUF945). This family consists of several hypothetical bacterial proteins of unknown function.",".",".",".",".","."]
["ENSRNOG00000030914",16,1.328426568,55,3.5381741,0.375455399,-1.413286557,1.51791E-4,1.71418E-4,"down","yes","Lexm","protein_coding","chr5:121375998-121401869:-","gi|157824111|ref|NP_001102732.1|",2038,0,"uncharacterized protein C1orf177 homolog [Rattus norvegicus]","gi|240255464|ref|NM_001109262.2|",1950,0,"Rattus norvegicus lymphocyte expansion molecule (Lexm), mRNA","B1H283",789,0,"Lymphocyte expansion molecule",".",".",".",".","pfam07004","SHIPPO-rpt","Sperm-tail PG-rich repeat. This family represents a short conserved region carrying a PGP motif that is repeated in eukaryotic proteins of sperm-tails. Shippo orthologues from some species may include up to 40 Pro-Gly-Pro repeats.","GO:0008284|positive regulation of cell proliferation;GO:1903862|positive regulation of oxidative phosphorylation;","GO:0005739|mitochondrion;","GO:0097177|mitochondrial ribosome binding;",".","."]
["ENSRNOG00000003374",4,0.332106642,27,1.736921831,0.191204138,-2.386814346,0.000152734,1.72392E-4,"down","yes","Ccdc85a","protein_coding","chr14:102129029-102359058:-","gi|568970157|ref|XP_006514717.1|",2415,0,"PREDICTED: coiled-coil domain-containing protein 85A isoform X1 [Mus musculus]","gi|755536347|ref|XM_006514654.2|",1983,0,"PREDICTED: Mus musculus coiled-coil domain containing 85A (Ccdc85a), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam10226","DUF2216","Uncharacterized conserved proteins (DUF2216). This is the conserved N-terminal half of a proteins which are found from worms to humans. some annotation suggests it might be PKR, the Hepatitis delta antigen-interacting protein A, but this could not be confirmed.","GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005912|adherens junction;","GO:0003674|molecular_function;",".","."]
["ENSRNOG00000003614",33,2.739879797,88,5.66107856,0.483985475,-1.046964343,0.000155395,0.000175227,"down","yes","Mgat5","protein_coding","chr13:38676119-38959513:+","gi|12831213|ref|NP_075583.1|",3771,0,"alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A [Rattus norvegicus]","gi|12831212|ref|NM_023095.1|",2516,0,"Rattus norvegicus mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase (Mgat5), mRNA","Q08834",1457,0,"Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A",".",".",".",".","pfam15024","Glyco_transf_18","Glycosyltransferase family 18. Enzymes belonging to glycosyltransferase family 18 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase) contribute to the creation of branches in complex-type N-glycans. This domain is responsible for the catalytic activity of the enzyme.","GO:0006487|protein N-linked glycosylation;GO:0018279|protein N-linked glycosylation via asparagine;GO:0030335|positive regulation of cell migration;GO:1903614|negative regulation of protein tyrosine phosphatase activity;GO:1904894|positive regulation of STAT cascade;","GO:0000139|Golgi membrane;GO:0005576|extracellular region;GO:0005794|Golgi apparatus;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0004864|protein phosphatase inhibitor activity;GO:0008375|acetylglucosaminyltransferase activity;GO:0016757|transferase activity, transferring glycosyl groups;GO:0030144|alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity;GO:0030145|manganese ion binding;","K00744","MGAT5; alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetyl-glucosaminyltransferase [EC:2.4.1.155]"]
["ENSRNOG00000063458",33,2.739879797,88,5.66107856,0.483985475,-1.046964343,0.000155395,0.000175227,"down","yes","ENSRNOG00000063458","lncRNA","chr8:889638-899464:+",".",".",".",".","gi|755528192|ref|XM_011242361.1|",1934,0,"PREDICTED: Mus musculus guanylate cyclase 1, soluble, alpha 2 (Gucy1a2), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam14093","DUF4271","Domain of unknown function (DUF4271). This family of integral membrane proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 221 and 326 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000028767",19,1.57750655,61,3.924156729,0.401998865,-1.314736668,1.5992E-4,1.79867E-4,"down","yes","AABR07001926.1","protein_coding","chr1:62509056-62528102:-","gi|148673829|gb|EDL05776.1|",1795,0,"mCG22919 [Mus musculus]","gi|331028450|ref|NG_028550.1|",676,0,"Mus musculus zinc finger protein 945 pseudogene (LOC100534296) on chromosome 17","Q8TAQ5",398,{"v":6e-127,"d":"6.00E-127"},"Zinc finger protein 420",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000031099",20,1.66053321,63,4.052817606,0.409723154,-1.287278672,1.60447E-4,1.80397E-4,"down","yes","Tmprss12","protein_coding","chr7:131433484-131445791:+","gi|564309423|ref|XP_003754410.2|",1561,0,"PREDICTED: transmembrane protease serine 12 [Rattus norvegicus]","gi|672022391|ref|XM_003754362.3|",1294,0,"PREDICTED: Rattus norvegicus transmembrane (C-terminal) protease, serine 12 (Tmprss12), mRNA","Q3V0Q7",525,0,"Transmembrane protease serine 12","VC1649",118,{"v":4e-28,"d":"4.00E-28"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0007339|binding of sperm to zona pellucida;GO:0016485|protein processing;","GO:0001669|acrosomal vesicle;","GO:0004252|serine-type endopeptidase activity;",".","."]
["ENSRNOG00000004854",3,0.249079982,24,1.543930516,0.161328492,-2.631926844,1.61337E-4,0.000181333,"down","yes","Has2","protein_coding","chr7:88113326-88128933:-","gi|6981008|ref|NP_037285.1|",2771,0,"hyaluronan synthase 2 precursor [Rattus norvegicus]","gi|6981007|ref|NM_013153.1|",3657,0,"Rattus norvegicus hyaluronan synthase 2 (Has2), mRNA","O35776",1070,0,"Hyaluronan synthase 2","SPy2200",138,{"v":2e-33,"d":"2.00E-33"},"COG1215","pfam03142","Chitin_synth_2","Chitin synthase. Members of this family are fungal chitin synthase EC:2.4.1.16 enzymes. They catalyse chitin synthesis as follows: UDP-N-acetyl-D-glucosamine + {(1,4)-(N-acetyl-beta-D-glucosaminyl)}(N) <=> UDP + {(1,4)-(N-acetyl-beta-D-glucosaminyl)}(N+1).","GO:0001570|vasculogenesis;GO:0001822|kidney development;GO:0008284|positive regulation of cell proliferation;GO:0010838|positive regulation of keratinocyte proliferation;GO:0014911|positive regulation of smooth muscle cell migration;GO:0030212|hyaluronan metabolic process;GO:0030213|hyaluronan biosynthetic process;GO:0030335|positive regulation of cell migration;GO:0035810|positive regulation of urine volume;GO:0036120|cellular response to platelet-derived growth factor stimulus;GO:0036302|atrioventricular canal development;GO:0044849|estrous cycle;GO:0045226|extracellular polysaccharide biosynthetic process;GO:0051549|positive regulation of keratinocyte migration;GO:0060349|bone morphogenesis;GO:0070295|renal water absorption;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071498|cellular response to fluid shear stress;GO:0085029|extracellular matrix assembly;GO:0090500|endocardial cushion to mesenchymal transition;GO:1900026|positive regulation of substrate adhesion-dependent cell spreading;GO:1900127|positive regulation of hyaluronan biosynthetic process;GO:1900625|positive regulation of monocyte aggregation;GO:1901201|regulation of extracellular matrix assembly;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005887|integral component of plasma membrane;GO:0031410|cytoplasmic vesicle;GO:0044853|plasma membrane raft;","GO:0003674|molecular_function;GO:0050501|hyaluronan synthase activity;","K00752","hasA; hyaluronan synthase [EC:2.4.1.212]"]
["ENSRNOG00000018839",3,0.249079982,24,1.543930516,0.161328492,-2.631926844,1.61337E-4,0.000181333,"down","yes","Ntrk2","protein_coding","chr17:5559043-5869136:-","gi|253683488|ref|NP_001156640.1|",2434,0,"BDNF/NT-3 growth factors receptor isoform 2 precursor [Rattus norvegicus]","gi|402534544|ref|NM_001163168.2|",6931,0,"Rattus norvegicus neurotrophic tyrosine kinase, receptor, type 2 (Ntrk2), transcript variant 2, mRNA","Q63604",923,0,"BDNF/NT-3 growth factors receptor",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0001570|vasculogenesis;GO:0001764|neuron migration;GO:0006954|inflammatory response;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007178|transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0007275|multicellular organism development;GO:0007528|neuromuscular junction development;GO:0007568|aging;GO:0007612|learning;GO:0007616|long-term memory;GO:0007623|circadian rhythm;GO:0007631|feeding behavior;GO:0008284|positive regulation of cell proliferation;GO:0009416|response to light stimulus;GO:0010628|positive regulation of gene expression;GO:0010976|positive regulation of neuron projection development;GO:0010996|response to auditory stimulus;GO:0014047|glutamate secretion;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0019222|regulation of metabolic process;GO:0019227|neuronal action potential propagation;GO:0021954|central nervous system neuron development;GO:0021987|cerebral cortex development;GO:0022011|myelination in peripheral nervous system;GO:0030182|neuron differentiation;GO:0031547|brain-derived neurotrophic factor receptor signaling pathway;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0033674|positive regulation of kinase activity;GO:0035584|calcium-mediated signaling using intracellular calcium source;GO:0038179|neurotrophin signaling pathway;GO:0042490|mechanoreceptor differentiation;GO:0043087|regulation of GTPase activity;GO:0043408|regulation of MAPK cascade;GO:0043410|positive regulation of MAPK cascade;GO:0043524|negative regulation of neuron apoptotic process;GO:0046548|retinal rod cell development;GO:0046777|protein autophosphorylation;GO:0046928|regulation of neurotransmitter secretion;GO:0048709|oligodendrocyte differentiation;GO:0048935|peripheral nervous system neuron development;GO:0050772|positive regulation of axonogenesis;GO:0050773|regulation of dendrite development;GO:0051896|regulation of protein kinase B signaling;GO:0051965|positive regulation of synapse assembly;GO:0051968|positive regulation of synaptic transmission, glutamatergic;GO:0060041|retina development in camera-type eye;GO:0060291|long-term synaptic potentiation;GO:0071230|cellular response to amino acid stimulus;GO:0071356|cellular response to tumor necrosis factor;GO:0099183|trans-synaptic signaling by BDNF, modulating synaptic transmission;GO:0099551|trans-synaptic signaling by neuropeptide, modulating synaptic transmission;GO:1902430|negative regulation of amyloid-beta formation;GO:1990090|cellular response to nerve growth factor stimulus;GO:1990416|cellular response to brain-derived neurotrophic factor stimulus;GO:2000324|positive regulation of glucocorticoid receptor signaling pathway;GO:2000811|negative regulation of anoikis;","GO:0000139|Golgi membrane;GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005769|early endosome;GO:0005791|rough endoplasmic reticulum;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0014069|postsynaptic density;GO:0030424|axon;GO:0030425|dendrite;GO:0030426|growth cone;GO:0031901|early endosome membrane;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0043197|dendritic spine;GO:0043204|perikaryon;GO:0043235|receptor complex;GO:0043679|axon terminus;GO:0045211|postsynaptic membrane;GO:0048471|perinuclear region of cytoplasm;GO:0048786|presynaptic active zone;GO:0060076|excitatory synapse;GO:0098794|postsynapse;GO:0098978|glutamatergic synapse;","GO:0002020|protease binding;GO:0004675|transmembrane receptor protein serine/threonine kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0005030|neurotrophin receptor activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0030971|receptor tyrosine kinase binding;GO:0042803|protein homodimerization activity;GO:0043121|neurotrophin binding;GO:0048403|brain-derived neurotrophic factor binding;GO:0060175|brain-derived neurotrophic factor-activated receptor activity;","K04360","NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2 [EC:2.7.10.1]"]
["ENSRNOG00000002937",8,0.664213284,37,2.380226213,0.279054688,-1.841380209,0.00017079,0.000191419,"down","yes","Ren","protein_coding","chr13:44796091-44807489:+","gi|148747255|ref|NP_036774.4|",2092,0,"renin precursor [Rattus norvegicus]","gi|206608|gb|J02941.1|RATREN",1558,0,"Rat renin mRNA, complete cds","P08424",810,0,"Renin",".",".",".",".","pfam00026","Asp","Eukaryotic aspartyl protease. Aspartyl (acid) proteases include pepsins, cathepsins, and renins. Two-domain structure, probably arising from ancestral duplication. This family does not include the retroviral nor retrotransposon proteases (pfam00077), which are much smaller and appear to be homologous to a single domain of the eukaryotic asp proteases.","GO:0001822|kidney development;GO:0001823|mesonephros development;GO:0002003|angiotensin maturation;GO:0002016|regulation of blood volume by renin-angiotensin;GO:0002018|renin-angiotensin regulation of aldosterone production;GO:0006508|proteolysis;GO:0008217|regulation of blood pressure;GO:0008584|male gonad development;GO:0009410|response to xenobiotic stimulus;GO:0009755|hormone-mediated signaling pathway;GO:0010033|response to organic substance;GO:0032496|response to lipopolysaccharide;GO:0035902|response to immobilization stress;GO:0042756|drinking behavior;GO:0043408|regulation of MAPK cascade;GO:0048469|cell maturation;GO:0050435|amyloid-beta metabolic process;GO:0051591|response to cAMP;GO:0070305|response to cGMP;GO:0071466|cellular response to xenobiotic stimulus;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0016020|membrane;GO:0045177|apical part of cell;","GO:0004175|endopeptidase activity;GO:0004190|aspartic-type endopeptidase activity;GO:0005102|signaling receptor binding;GO:0005159|insulin-like growth factor receptor binding;GO:0008233|peptidase activity;","K01380","REN; renin [EC:3.4.23.15]"]
["ENSRNOG00000021493",30,2.490799816,82,5.275095931,0.472180951,-1.082588253,1.75384E-4,0.000196259,"down","yes","Prdm9","protein_coding","chr1:56505579-56525652:-","gi|281485597|ref|NP_001102373.2|",4297,0,"histone-lysine N-methyltransferase PRDM9 [Rattus norvegicus]","gi|281485596|ref|NM_001108903.2|",2688,0,"Rattus norvegicus PR domain 9 (Prdm9), mRNA","P0C6Y7",1659,0,"Histone-lysine N-methyltransferase PRDM9",".",".",".",".","pfam09514","SSXRD","SSXRD motif. SSX1 can repress transcription, and this has been attributed to a putative Kruppel associated box (KRAB) repression domain at the N-terminus. However, from the analysis of these deletion constructs further repression activity was found at the C-terminus of SSX1. Which has been called the SSXRD (SSX Repression Domain). The potent repression exerted by full-length SSX1 appears to localize to this region.","GO:0006311|meiotic gene conversion;GO:0007129|synapsis;GO:0007283|spermatogenesis;GO:0007292|female gamete generation;GO:0008150|biological_process;GO:0010468|regulation of gene expression;GO:0010845|positive regulation of reciprocal meiotic recombination;GO:0016571|histone methylation;GO:0016584|nucleosome positioning;GO:0034968|histone lysine methylation;GO:0043066|negative regulation of apoptotic process;GO:0044648|histone H3-K4 dimethylation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048232|male gamete generation;GO:0051567|histone H3-K9 methylation;GO:0051568|histone H3-K4 methylation;GO:0060903|positive regulation of meiosis I;GO:0080182|histone H3-K4 trimethylation;GO:0097198|histone H3-K36 trimethylation;GO:0097676|histone H3-K36 dimethylation;GO:0097692|histone H3-K4 monomethylation;GO:1905437|positive regulation of histone H3-K4 trimethylation;GO:1905516|positive regulation of fertilization;GO:1990918|double-strand break repair involved in meiotic recombination;GO:2001255|positive regulation of histone H3-K36 trimethylation;","GO:0000785|chromatin;GO:0005575|cellular_component;GO:0005634|nucleus;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0003674|molecular_function;GO:0010844|recombination hotspot binding;GO:0018024|histone-lysine N-methyltransferase activity;GO:0042800|histone methyltransferase activity (H3-K4 specific);GO:0042803|protein homodimerization activity;GO:0043565|sequence-specific DNA binding;GO:0046872|metal ion binding;GO:0046975|histone methyltransferase activity (H3-K36 specific);","K20796","PRDM7_9; [histone H3]-lysine4 N-trimethyltransferase PRDM7/9 [EC:2.1.1.354]"]
["ENSRNOG00000069263",36,2.988959779,93,5.982730751,0.49959791,-1.001160653,0.00017841,0.000199436,"down","yes","ENSRNOG00000069263","lncRNA","chr12:6037377-6059145:+","gi|537170890|gb|ERE74287.1|",156,9e-08,"caltractin-like protein [Cricetulus griseus]","gi|50838840|gb|AC128270.3|",3374,0,"Rattus norvegicus 12 BAC CH230-48A22 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam11864","DUF3384","Domain of unknown function (DUF3384). This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is typically between 422 to 486 amino acids in length. This domain is found associated with pfam02145.",".",".",".",".","."]
["ENSRNOG00000002792",13,1.079346587,48,3.087861033,0.349545065,-1.516449626,1.91557E-4,0.000213163,"down","yes","Cxcl2","protein_coding","chr14:17181062-17183075:-","gi|16758460|ref|NP_446099.1|",440,{"v":2E-50,"d":"2.00E-50"},"C-X-C motif chemokine 2 precursor [Rattus norvegicus]","gi|16758459|ref|NM_053647.1|",1041,0,"Rattus norvegicus chemokine (C-X-C motif) ligand 2 (Cxcl2), mRNA","P30348",174,{"v":6E-52,"d":"6.00E-52"},"C-X-C motif chemokine 2",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0001975|response to amphetamine;GO:0002237|response to molecule of bacterial origin;GO:0006954|inflammatory response;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0009408|response to heat;GO:0010332|response to gamma radiation;GO:0030593|neutrophil chemotaxis;GO:0030595|leukocyte chemotaxis;GO:0031640|killing of cells of other organism;GO:0032355|response to estradiol;GO:0042060|wound healing;GO:0051384|response to glucocorticoid;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098|chemokine-mediated signaling pathway;GO:0070997|neuron death;GO:0071222|cellular response to lipopolysaccharide;GO:0071347|cellular response to interleukin-1;","GO:0005615|extracellular space;","GO:0008009|chemokine activity;GO:0045236|CXCR chemokine receptor binding;","K05505","CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3"]
["ENSRNOG00000001830",14,1.162373247,50,3.216521909,0.361375822,-1.468428112,0.000201551,0.0002237,"down","yes","Arntl2","protein_coding","chr4:179699502-179746949:+","gi|379135494|gb|AFC93435.1|",2986,0,"brain and muscle Arnt-like protein 2 variant d [Rattus norvegicus]","gi|297206837|ref|NM_133391.1|",1839,0,"Rattus norvegicus aryl hydrocarbon receptor nuclear translocator-like 2 (Arntl2), mRNA","Q2VPD4",946,0,"Aryl hydrocarbon receptor nuclear translocator-like protein 2",".",".",".",".","pfam14598","PAS_11","PAS domain. This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).","GO:0006357|regulation of transcription by RNA polymerase II;GO:0007623|circadian rhythm;GO:0042753|positive regulation of circadian rhythm;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0034751|aryl hydrocarbon receptor complex;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003700|DNA-binding transcription factor activity;GO:0046983|protein dimerization activity;GO:0070888|E-box binding;","K09099","ARNTL2, BMAL2; aryl hydrocarbon receptor nuclear translocator-like protein 2"]
["ENSRNOG00000003972",1,0.083026661,17,1.093617449,0.07591929,-3.719389685,0.000201849,2.2391499999999999E-4,"down","yes","Tshr","protein_coding","chr6:110341581-110474538:+","gi|149025304|gb|EDL81671.1|",3878,0,"rCG20940 [Rattus norvegicus]","gi|6981679|ref|NM_012888.1|",4431,0,"Rattus norvegicus thyroid stimulating hormone receptor (Tshr), mRNA","P21463",1487,0,"Thyrotropin receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007166|cell surface receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007190|activation of adenylate cyclase activity;GO:0008284|positive regulation of cell proliferation;GO:0008344|adult locomotory behavior;GO:0009755|hormone-mediated signaling pathway;GO:0030183|B cell differentiation;GO:0038194|thyroid-stimulating hormone signaling pathway;GO:0040012|regulation of locomotion;GO:0040018|positive regulation of multicellular organism growth;GO:0060122|inner ear receptor cell stereocilium organization;GO:0071542|dopaminergic neuron differentiation;GO:0090103|cochlea morphogenesis;GO:0120162|positive regulation of cold-induced thermogenesis;GO:1904588|cellular response to glycoprotein;GO:1905229|cellular response to thyrotropin-releasing hormone;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0043235|receptor complex;GO:0045121|membrane raft;","GO:0004996|thyroid-stimulating hormone receptor activity;GO:0008528|G protein-coupled peptide receptor activity;GO:0038023|signaling receptor activity;GO:0044877|protein-containing complex binding;","K04249","TSHR; thyrotropin receptor"]
["ENSRNOG00000058906",1,0.083026661,17,1.093617449,0.07591929,-3.719389685,0.000201849,2.2391499999999999E-4,"down","yes","Ptprh","protein_coding","chr1:69242321-69285077:+","gi|300794452|ref|NP_001178874.1|",4371,0,"receptor-type tyrosine-protein phosphatase H precursor [Rattus norvegicus]","gi|672034916|ref|XM_008758887.1|",2272,0,"PREDICTED: Rattus norvegicus protein tyrosine phosphatase, receptor type, H (Ptprh), transcript variant X1, mRNA","E9Q0N2",1371,0,"Receptor-type tyrosine-protein phosphatase H","SPAC11E3.09",129,{"v":7e-31,"d":"7.00E-31"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:1990264|peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity;","GO:0005902|microvillus;GO:0016021|integral component of membrane;","GO:0005001|transmembrane receptor protein tyrosine phosphatase activity;GO:0045296|cadherin binding;","K18034","PTPRH, SAP1; receptor-type tyrosine-protein phosphatase H [EC:3.1.3.48]"]
["ENSRNOG00000042224",33,2.739879797,87,5.596748122,0.489548527,-1.03047622,0.000205547,0.000227701,"down","yes","Cyp2j10","protein_coding","chr5:110960317-110995115:-","gi|201066389|ref|NP_001128452.1|",2617,0,"cytochrome P450, family 2, subfamily j, polypeptide 10 [Rattus norvegicus]","gi|201066388|ref|NM_001134980.1|",1903,0,"Rattus norvegicus cytochrome P450, family 2, subfamily j, polypeptide 10 (Cyp2j10), mRNA","P51590",777,0,"Cytochrome P450 2J3","alr1450",135,{"v":3e-33,"d":"3.00E-33"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0006082|organic acid metabolic process;GO:0006805|xenobiotic metabolic process;GO:0019373|epoxygenase P450 pathway;GO:0042178|xenobiotic catabolic process;GO:0043651|linoleic acid metabolic process;","GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0005506|iron ion binding;GO:0008395|steroid hydroxylase activity;GO:0008404|arachidonic acid 14,15-epoxygenase activity;GO:0008405|arachidonic acid 11,12-epoxygenase activity;GO:0016712|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0016853|isomerase activity;GO:0020037|heme binding;GO:0071614|linoleic acid epoxygenase activity;","K07418","CYP2J; cytochrome P450 family 2 subfamily J [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]"]
["ENSRNOG00000067940",15,1.245399908,52,3.345182786,0.372296519,-1.425475966,2.0949E-4,2.31747E-4,"down","yes","ENSRNOG00000067940","lncRNA","chr2:182593209-182598658:+","gi|67975423|ref|XP_668908.1|",162,{"v":5e-10,"d":"5.00E-10"},"hypothetical protein [Plasmodium berghei strain ANKA], partial [Plasmodium berghei ANKA]","gi|40841709|gb|AC130969.4|",4555,0,"Rattus norvegicus 2 BAC CH230-105B13 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam06085","Rz1","Lipoprotein Rz1 precursor. This family consists of several bacteria and phage lipoprotein Rz1 precursors. Rz1 is a proline-rich lipoprotein from bacteriophage lambda which is known to have fusogenic properties. Rz1-induced liposome fusion is thought to be mediated primarily by the generation of local perturbation in the bilayer lipid membrane and to a lesser extent by electrostatic forces. This family Rz1 and the Rz protein Rz (pfam03245) represent a unique example of two genes located in different reading frames in the same nucleotide sequence, which encode different proteins that are both required in the same physiological pathway.",".",".",".",".","."]
["ENSRNOG00000025117",5,0.415133303,29,1.865582707,0.222522058,-2.167979744,2.13666E-4,0.000236163,"down","yes","Noxo1","protein_coding","chr10:13721473-13726061:+","gi|564370938|ref|XP_006246010.1|",1556,0,"PREDICTED: NADPH oxidase organizer 1 isoform X1 [Rattus norvegicus]","gi|672066855|ref|XM_008767566.1|",1330,0,"PREDICTED: Rattus norvegicus NADPH oxidase organizer 1 (Noxo1), transcript variant X1, mRNA","Q8VCM2",529,0,"NADPH oxidase organizer 1",".",".",".",".","pfam00018","SH3_1","SH3 domain. SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta barrel.","GO:0006801|superoxide metabolic process;GO:0022617|extracellular matrix disassembly;GO:0042554|superoxide anion generation;GO:0050790|regulation of catalytic activity;","GO:0005737|cytoplasm;GO:0043020|NADPH oxidase complex;","GO:0016176|superoxide-generating NADPH oxidase activator activity;GO:0019899|enzyme binding;GO:0035091|phosphatidylinositol binding;","K17934","NOXO1, SNX28; NADPH oxidase organizer 1"]
["ENSRNOG00000007232",0,0.04151333,15,0.964956573,0.043020931,-4.538817439,2.18667E-4,2.41356E-4,"down","yes","Lao1","protein_coding","chr5:132573698-132583582:+","gi|157817668|ref|NP_001100152.1|",2519,0,"L-amino acid oxidase 1 precursor [Rattus norvegicus]","gi|157817667|ref|NM_001106682.1|",1887,0,"Rattus norvegicus L-amino acid oxidase 1 (Lao1), mRNA","A8QL52",464,{"v":3e-155,"d":"3.00E-155"},"L-amino-acid oxidase","BS_yobN",218,{"v":2e-62,"d":"2.00E-62"},"COG1231","pfam01593","Amino_oxidase","Flavin containing amine oxidoreductase. This family consists of various amine oxidases, including maze polyamine oxidase (PAO) and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.","GO:0009063|cellular amino acid catabolic process;","GO:0005576|extracellular region;","GO:0001716|L-amino-acid oxidase activity;GO:0016491|oxidoreductase activity;GO:0046592|polyamine oxidase activity;","K03334","IL4I1; L-amino-acid oxidase [EC:1.4.3.2]"]
["ENSRNOG00000067280",7,0.581186624,34,2.187234898,0.265717516,-1.912034763,0.000219164,0.00024178,"down","yes","ENSRNOG00000067280","protein_coding","chr9:12941405-12943070:+","gi|392342242|ref|XP_003754540.1|",966,{"v":1e-128,"d":"1.00E-128"},"PREDICTED: histone H3.v1-like isoform X2 [Rattus norvegicus]","gi|672064478|ref|XM_003750642.3|",802,0,"PREDICTED: Rattus norvegicus uncharacterized LOC100911489 (LOC100911489), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.",".",".",".",".","."]
["ENSRNOG00000019339",10,0.830266605,41,2.637547966,0.314787301,-1.667550754,0.000221858,0.000244583,"down","yes","Ttll11","protein_coding","chr3:19110284-19335969:-","gi|392346263|ref|XP_001071863.3|",3596,0,"PREDICTED: tubulin polyglutamylase TTLL11 isoform X3 [Rattus norvegicus]","gi|672045460|ref|XM_001071863.5|",2101,0,"PREDICTED: Rattus norvegicus tubulin tyrosine ligase-like family, member 11 (Ttll11), transcript variant X3, mRNA","A4Q9F4",1228,0,"Tubulin polyglutamylase TTLL11",".",".",".",".","pfam03133","TTL","Tubulin-tyrosine ligase family. Tubulins and microtubules are subjected to several post-translational modifications of which the reversible detyrosination/tyrosination of the carboxy-terminal end of most alpha-tubulins has been extensively analysed. This modification cycle involves a specific carboxypeptidase and the activity of the tubulin-tyrosine ligase (TTL). The true physiological function of TTL has so far not been established. Tubulin-tyrosine ligase (TTL) catalyses the ATP-dependent post-translational addition of a tyrosine to the carboxy terminal end of detyrosinated alpha-tubulin. In normally cycling cells, the tyrosinated form of tubulin predominates. However, in breast cancer cells, the detyrosinated form frequently predominates, with a correlation to tumor aggressiveness. On the other hand, 3-nitrotyrosine has been shown to be incorporated, by TTL, into the carboxy terminal end of detyrosinated alpha-tubulin. This reaction is not reversible by the carboxypeptidase enzyme. Cells cultured in 3-nitrotyrosine rich medium showed evidence of altered microtubule structure and function, including altered cell morphology, epithelial barrier dysfunction, and apoptosis. Bacterial homologs of TTL are predicted to form peptide tags. Some of these are fused to a 2-oxoglutarate Fe(II)-dependent dioxygenase domain.","GO:0018095|protein polyglutamylation;GO:0051013|microtubule severing;","GO:0036064|ciliary basal body;",".","K16604","TTLL11; tubulin polyglutamylase TTLL11 [EC:6.3.2.-]"]
["ENSRNOG00000066862",20,1.66053321,62,3.988487167,0.416331592,-1.264195059,2.2264E-4,0.000245318,"down","yes","ENSRNOG00000066862","protein_coding","chr1:116014375-116016228:-","gi|114145551|ref|NP_001041367.1|",1191,{"v":2e-154,"d":"2.00E-154"},"zinc finger CCCH domain-containing protein 11A [Rattus norvegicus]","gi|672013779|ref|XR_085718.4|",824,0,"PREDICTED: Rattus norvegicus similar to Zinc finger CCCH-type domain-containing protein 11A (LOC680017), transcript variant X1, misc_RNA","Q6NZF1",430,{"v":3e-143,"d":"3.00E-143"},"Zinc finger CCCH domain-containing protein 11A",".",".",".",".","pfam09533","DUF2380","Predicted lipoprotein of unknown function (DUF2380). This family consists of at least 9 paralogs in Myxococcus xanthus, a member of the Deltaproteobacteria. One appears truncated toward the N-terminus; the others are predicted lipoproteins. The function is unknown.",".",".",".",".","."]
["ENSRNOG00000002381",11,0.913293266,43,2.766208842,0.330160634,-1.59875998,0.000243311,0.000266442,"down","yes","Bmp3","protein_coding","chr14:10712489-10737153:-","gi|149046840|gb|EDL99614.1|",2434,0,"bone morphogenetic protein 3, isoform CRA_b [Rattus norvegicus]","gi|8392992|ref|NM_017105.1|",2140,0,"Rattus norvegicus bone morphogenetic protein 3 (Bmp3), mRNA","P49002",917,0,"Bone morphogenetic protein 3",".",".",".",".","pfam00019","TGF_beta","Transforming growth factor beta like domain.","GO:0001649|osteoblast differentiation;GO:0007165|signal transduction;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051216|cartilage development;GO:0060395|SMAD protein signal transduction;","GO:0005615|extracellular space;GO:0031982|vesicle;","GO:0005125|cytokine activity;GO:0008083|growth factor activity;GO:0070700|BMP receptor binding;","K05496","BMP3; bone morphogenetic protein 3"]
["ENSRNOG00000003997",8,0.664213284,36,2.315895775,0.286806208,-1.801851845,0.000259277,0.000282523,"down","yes","Pld5","protein_coding","chr13:87896369-88232868:-","gi|880927737|ref|XP_012974586.1|",2786,0,"PREDICTED: inactive phospholipase D5 isoform X1 [Mesocricetus auratus]","gi|300794157|ref|NM_001191674.1|",1531,0,"Rattus norvegicus phospholipase D family, member 5 (Pld5), mRNA","Q3UNN8",956,0,"Inactive phospholipase D5",".",".",".",".","pfam13918","PLDc_3","PLD-like domain.","GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0003824|catalytic activity;","K16861","PLD5; inactive phospholipase D5"]
["ENSRNOG00000069177",8,0.664213284,36,2.315895775,0.286806208,-1.801851845,0.000259277,0.000282523,"down","yes","ENSRNOG00000069177","lncRNA","chr2:172420539-172423316:-","gi|780025450|ref|XP_011665908.1|",451,{"v":7e-43,"d":"7.00E-43"},"PREDICTED: mucin-2-like [Strongylocentrotus purpuratus]","gi|354780612|gb|JN945113.1|",303,{"v":3e-155,"d":"3.00E-155"},"Mus musculus targeted deletion, lacZ-tagged mutant allele Cd1d1:tm1(KOMP)Wtsi; transgenic","P9WI15",82,{"v":2E-14,"d":"2.00E-14"},"Uncharacterized PPE family protein PPE24",".",".",".",".","pfam13440","Polysacc_synt_3","Polysaccharide biosynthesis protein.",".",".",".",".","."]
["ENSRNOG00000009815",12,0.996319926,45,2.894869718,0.344167449,-1.538817439,0.000261679,2.84849E-4,"down","yes","Pnma2","protein_coding","chr15:41112009-41121427:+","gi|157822619|ref|NP_001100742.1|",1763,0,"paraneoplastic antigen Ma2 [Rattus norvegicus]","gi|157822618|ref|NM_001107272.1|",3241,0,"Rattus norvegicus paraneoplastic Ma antigen 2 (Pnma2), mRNA","Q8BHK0",639,0,"Paraneoplastic antigen Ma2 homolog",".",".",".",".","pfam14893","PNMA","PNMA. The PNMA family includes paraneoplastic antigens Ma 1, 2 and 3, found in the serum of patients with paraneoplastic neurological disorders. The family also includes modulator of apoptosis 1, which has a role in death receptor-dependent apoptosis.",".","GO:0005730|nucleolus;",".",".","."]
["ENSRNOG00000031852",12,0.996319926,45,2.894869718,0.344167449,-1.538817439,0.000261679,2.84849E-4,"down","yes","Lsamp","protein_coding","chr11:58554805-60717029:-","gi|30425330|ref|NP_780757.1|",1527,0,"limbic system-associated membrane protein precursor [Mus musculus]","gi|672071129|ref|XM_006248339.2|",1423,0,"PREDICTED: Rattus norvegicus limbic system-associated membrane protein (Lsamp), transcript variant X1, mRNA","Q8BLK3",592,0,"Limbic system-associated membrane protein",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0007155|cell adhesion;GO:0035641|locomotory exploration behavior;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0031225|anchored component of membrane;",".","K06772","LSAMP, LAMP; limbic system-associated membrane protein"]
["ENSRNOG00000017421",26,2.158693174,73,4.696121987,0.459675703,-1.121311685,0.000270232,0.000293809,"down","yes","Alpk2","pseudogene","chr18:58775605-58906258:-","gi|564393878|ref|XP_006254949.1|",10586,0,"PREDICTED: alpha-protein kinase 2 [Rattus norvegicus]","gi|672083733|ref|XM_006254887.2|",6384,0,"PREDICTED: Rattus norvegicus alpha-kinase 2 (Alpk2), mRNA","Q91ZB0",3364,0,"Alpha-protein kinase 2",".",".",".",".","pfam02816","Alpha_kinase","Alpha-kinase family. This family is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional kinases. The family contains myosin heavy chain kinases and Elongation Factor-2 kinase and a bifunctional ion channel. This family is known as the alpha-kinase family. The structure of the kinase domain revealed unexpected similarity to eukaryotic protein kinases in the catalytic core as well as to metabolic enzymes with ATP-grasp domains.","GO:0003007|heart morphogenesis;GO:0003308|negative regulation of Wnt signaling pathway involved in heart development;GO:0006468|protein phosphorylation;GO:0010468|regulation of gene expression;GO:0030010|establishment of cell polarity;GO:0042981|regulation of apoptotic process;GO:0055013|cardiac muscle cell development;GO:1905223|epicardium morphogenesis;","GO:0016323|basolateral plasma membrane;","GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;","K08868","ALPK; alpha-kinase"]
["ENSRNOG00000010556",13,1.079346587,47,3.023530595,0.356982194,-1.486075977,0.000276902,3.00601E-4,"down","yes","NEWGENE_1309446","protein_coding","chr2:123609807-123682676:+","gi|564300251|ref|XP_006224171.1|",4317,0,"PREDICTED: protein inturned isoform X1 [Rattus norvegicus]","gi|672015722|ref|XM_006224109.2|",2050,0,"PREDICTED: Rattus norvegicus inturned planar cell polarity protein (Intu), transcript variant X1, mRNA","D4ACE5",1662,0,"Protein inturned",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.",".",".",".",".","."]
["ENSRNOG00000015076",13,1.079346587,47,3.023530595,0.356982194,-1.486075977,0.000276902,3.00601E-4,"down","yes","Cyp26b1","protein_coding","chr4:117041808-117058628:-","gi|148666702|gb|EDK99118.1|",2864,0,"cytochrome P450, family 26, subfamily b, polypeptide 1, isoform CRA_b, partial [Mus musculus]","gi|31342016|ref|NM_181087.2|",4532,0,"Rattus norvegicus cytochrome P450, family 26, subfamily b, polypeptide 1 (Cyp26b1), mRNA","G3V7X8",1019,0,"Cytochrome P450 26B1","slr0574",266,{"v":8e-77,"d":"8.00E-77"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0001709|cell fate determination;GO:0001768|establishment of T cell polarity;GO:0001822|kidney development;GO:0006805|xenobiotic metabolic process;GO:0006954|inflammatory response;GO:0007140|male meiotic nuclear division;GO:0007283|spermatogenesis;GO:0009954|proximal/distal pattern formation;GO:0010628|positive regulation of gene expression;GO:0016125|sterol metabolic process;GO:0030326|embryonic limb morphogenesis;GO:0032526|response to retinoic acid;GO:0033189|response to vitamin A;GO:0034653|retinoic acid catabolic process;GO:0042573|retinoic acid metabolic process;GO:0043587|tongue morphogenesis;GO:0045580|regulation of T cell differentiation;GO:0048384|retinoic acid receptor signaling pathway;GO:0048385|regulation of retinoic acid receptor signaling pathway;GO:0048387|negative regulation of retinoic acid receptor signaling pathway;GO:0060349|bone morphogenesis;GO:0061436|establishment of skin barrier;GO:0070268|cornification;GO:0071300|cellular response to retinoic acid;GO:2001037|positive regulation of tongue muscle cell differentiation;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005789|endoplasmic reticulum membrane;","GO:0001972|retinoic acid binding;GO:0004497|monooxygenase activity;GO:0005506|iron ion binding;GO:0008401|retinoic acid 4-hydroxylase activity;GO:0016491|oxidoreductase activity;GO:0016709|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;GO:0020037|heme binding;","K12664","CYP26B; cytochrome P450 family 26 subfamily B [EC:1.14.14.-]"]
["ENSRNOG00000004843",32,2.656853137,84,5.403756808,0.491667784,-1.024244267,0.000284087,0.000307774,"down","yes","Pole3","protein_coding","chr7:109236321-109236758:-","gi|532017852|ref|XP_005352678.1|",495,{"v":4e-61,"d":"4.00E-61"},"PREDICTED: DNA polymerase epsilon subunit 3 [Microtus ochrogaster]","gi|672022077|ref|XM_002726945.4|",438,0,"PREDICTED: Rattus norvegicus DNA-directed DNA polymerase epsilon 3 (LOC100362333), mRNA","Q5R4W3",195,{"v":2e-62,"d":"2.00E-62"},"DNA polymerase epsilon subunit 3",".",".",".",".","pfam00808","CBFD_NFYB_HMF","Histone-like transcription factor (CBF/NF-Y) and archaeal histone. This family includes archaebacterial histones and histone like transcription factors from eukaryotes.","GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0008622|epsilon DNA polymerase complex;","GO:0003674|molecular_function;GO:0046982|protein heterodimerization activity;","K02326","POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]"]
["ENSRNOG00000064496",24,1.992639853,69,4.438800235,0.448914064,-1.1554888,0.000286211,0.000309865,"down","yes","ENSRNOG00000064496","lncRNA","chr10:96054824-96060758:-",".",".",".",".","gi|672069706|ref|XM_006247567.2|",2849,0,"PREDICTED: Rattus norvegicus potassium inwardly-rectifying channel, subfamily J, member 2 (Kcnj2), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam03411","Peptidase_M74","Penicillin-insensitive murein endopeptidase.",".",".",".",".","."]
["ENSRNOG00000021553",16,1.328426568,53,3.409513224,0.389623527,-1.359847298,0.000304681,0.000328693,"down","yes","Nckap5","protein_coding","chr13:37370792-38283268:-","gi|672027054|ref|XP_008759654.1|",8222,0,"PREDICTED: nck-associated protein 5 isoform X2 [Rattus norvegicus]","gi|672073910|ref|XM_008769508.1|",5713,0,"PREDICTED: Rattus norvegicus NCK-associated protein 5 (Nckap5), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam15246","NCKAP5","Nck-associated protein 5, Peripheral clock protein. NCKAP5 is short for Nck-associated protein 5, which is also known as the Peripheral clock protein. NCKAP5 is a protein family, which interacts with the SH3-containing region of the adaptor protein Nck. Nck is a protein that interacts with receptor tyrosine kinases and guanine nucleotide exchange factor Sos. The role of Nck can be thought of as similar to Grb2. The role of NCKAP5 is to assist Nck with its adaptor protein role.","GO:0001578|microtubule bundle formation;GO:0007019|microtubule depolymerization;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0035371|microtubule plus-end;","GO:0003674|molecular_function;",".","."]
["ENSRNOG00000006802",20,1.66053321,61,3.924156729,0.4231567,-1.240736086,0.000307818,0.000331629,"down","yes","Lrrn1","protein_coding","chr4:140476324-140518620:+","gi|82654226|ref|NP_001032440.1|",3768,0,"leucine-rich repeat neuronal protein 1 precursor [Rattus norvegicus]","gi|672050690|ref|XM_006236985.2|",5674,0,"PREDICTED: Rattus norvegicus leucine rich repeat neuronal 1 (Lrrn1), transcript variant X2, mRNA","Q32Q07",1456,0,"Leucine-rich repeat neuronal protein 1","alr0124_1",86.7,{"v":2E-16,"d":"2.00E-16"},"COG4886","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0051965|positive regulation of synapse assembly;","GO:0005615|extracellular space;GO:0016021|integral component of membrane;GO:0031012|extracellular matrix;",".","K24492","LRRN1_2_3; leucine-rich repeat neuronal protein 1/2/3"]
["ENSRNOG00000013781",17,1.411453229,55,3.5381741,0.398921361,-1.325823716,0.000308615,0.000332432,"down","yes","Kcnq5","protein_coding","chr9:23833087-24394704:-","gi|403225003|ref|NP_001128115.2|",4645,0,"potassium voltage-gated channel subfamily KQT member 5 [Rattus norvegicus]","gi|403225002|ref|NM_001134643.2|",3631,0,"Rattus norvegicus potassium voltage-gated channel subfamily Q member 5 (Kcnq5), mRNA","Q9JK45",1702,0,"Potassium voltage-gated channel subfamily KQT member 5","all4633",83.2,{"v":2E-16,"d":"2.00E-16"},"COG1226","pfam03520","KCNQ_channel","KCNQ voltage-gated potassium channel. This family matches to the C-terminal tail of KCNQ type potassium channels.","GO:0006813|potassium ion transport;GO:0034765|regulation of ion transmembrane transport;GO:0071805|potassium ion transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0008076|voltage-gated potassium channel complex;GO:0016021|integral component of membrane;GO:0030118|clathrin coat;","GO:0005249|voltage-gated potassium channel activity;GO:0005251|delayed rectifier potassium channel activity;GO:0005516|calmodulin binding;","K04930","KCNQ5, KV7.5; potassium voltage-gated channel KQT-like subfamily member 5"]
["ENSRNOG00000008855",7,0.581186624,33,2.12290446,0.273769562,-1.868966041,0.000336142,0.00035978,"down","yes","Gjb2","protein_coding","chr15:31260357-31278177:-","gi|148704234|gb|EDL36181.1|",1403,0,"gap junction membrane channel protein beta 2, isoform CRA_b, partial [Mus musculus]","gi|51871606|ref|NM_001004099.1|",2421,0,"Rattus norvegicus gap junction protein, beta 2 (Gjb2), mRNA","P21994",470,{"v":4E-159,"d":"4.00E-159"},"Gap junction beta-2 protein",".",".",".",".","pfam00029","Connexin","Connexin.","GO:0002931|response to ischemia;GO:0007267|cell-cell signaling;GO:0007565|female pregnancy;GO:0007568|aging;GO:0007605|sensory perception of sound;GO:0010644|cell communication by electrical coupling;GO:0016264|gap junction assembly;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0032526|response to retinoic acid;GO:0032570|response to progesterone;GO:0034599|cellular response to oxidative stress;GO:0044752|response to human chorionic gonadotropin;GO:0046677|response to antibiotic;GO:0046697|decidualization;GO:0048839|inner ear development;GO:0055085|transmembrane transport;GO:0071377|cellular response to glucagon stimulus;GO:0071549|cellular response to dexamethasone stimulus;GO:1905867|epididymis development;GO:1990349|gap junction-mediated intercellular transport;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005921|gap junction;GO:0005922|connexin complex;GO:0016328|lateral plasma membrane;GO:0030054|cell junction;GO:0044297|cell body;GO:0048471|perinuclear region of cytoplasm;GO:0097449|astrocyte projection;","GO:0005243|gap junction channel activity;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0042802|identical protein binding;GO:1903763|gap junction channel activity involved in cell communication by electrical coupling;","K07621","GJB2, CX26; gap junction beta-2 protein"]
["ENSRNOG00000010280",7,0.581186624,33,2.12290446,0.273769562,-1.868966041,0.000336142,0.00035978,"down","yes","Pde8b","protein_coding","chr2:26276635-26509209:-","gi|672041232|ref|XP_008758892.1|",4744,0,"PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X3 [Rattus norvegicus]","gi|672041231|ref|XM_008760670.1|",3049,0,"PREDICTED: Rattus norvegicus phosphodiesterase 8B (Pde8b), transcript variant X3, mRNA","E9Q4S1",1768,0,"High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B",".",".",".",".","pfam00233","PDEase_I","3'5'-cyclic nucleotide phosphodiesterase.","GO:0001662|behavioral fear response;GO:0006198|cAMP catabolic process;GO:0007165|signal transduction;GO:0008542|visual learning;GO:0035106|operant conditioning;GO:0046676|negative regulation of insulin secretion;GO:0050885|neuromuscular process controlling balance;GO:0061179|negative regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0090032|negative regulation of steroid hormone biosynthetic process;","GO:0005575|cellular_component;","GO:0003674|molecular_function;GO:0004114|3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0004115|3',5'-cyclic-AMP phosphodiesterase activity;GO:0046872|metal ion binding;","K18437","PDE8; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 [EC:3.1.4.53]"]
["ENSRNOG00000064022",27,2.241719834,74,4.760452426,0.470904787,-1.086492707,3.50527E-4,0.000373972,"down","yes","ENSRNOG00000064022","lncRNA","chr10:5273404-5277370:+",".",".",".",".","gi|672024497|ref|XR_598611.1|",690,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102553451 (LOC102553451), transcript variant X3, ncRNA",".",".",".",".",".",".",".",".","pfam11477","PM0188","Sialyltransferase PMO188. PMO188 is a sialyltransferase from P.multocida. It transfers sialic acid from cytidine 5'-monophosphonuraminic acid to an acceptor sugar. It has important catalytic residues such as Asp141, His311, Glu338, Ser355 and Ser356.",".",".",".",".","."]
["ENSRNOG00000048919",1,0.083026661,16,1.029287011,0.080664246,-3.631926844,0.000350629,0.000373972,"down","yes","Iho1","protein_coding","chr8:109092758-109125434:-","gi|392342107|ref|XP_003754504.1|",2700,0,"PREDICTED: coiled-coil domain-containing protein 36 [Rattus norvegicus]","gi|672023330|ref|XM_003754456.3|",1804,0,"PREDICTED: Rattus norvegicus coiled-coil domain containing 36 (Ccdc36), mRNA","Q6PDM4",798,0,"Interactor of HORMAD1 protein 1",".",".",".",".","pfam15479","DUF4639","Domain of unknown function (DUF4639). This family of proteins is found in eukaryotes. Proteins in this family are typically between 161 and 601 amino acids in length.","GO:0006310|DNA recombination;GO:0007129|synapsis;GO:0007283|spermatogenesis;GO:0042138|meiotic DNA double-strand break formation;GO:0048477|oogenesis;GO:0060629|regulation of homologous chromosome segregation;","GO:0000794|condensed nuclear chromosome;",".",".","."]
["ENSRNOG00000055025",1,0.083026661,16,1.029287011,0.080664246,-3.631926844,0.000350629,0.000373972,"down","yes","Fam25a","protein_coding","chr16:9680668-9684474:-","gi|148692929|gb|EDL24876.1|",229,{"v":6e-22,"d":"6.00E-22"},"RIKEN cDNA 2200001I15, partial [Mus musculus]","gi|198442839|ref|NM_001134849.1|",399,0,"Rattus norvegicus family with sequence similarity 25, member A (Fam25a), mRNA",".",".",".",".",".",".",".",".","pfam09900","DUF2127","Predicted membrane protein (DUF2127). This domain, found in various hypothetical prokaryotic and archaeal proteins, has no known function.",".",".",".",".","."]
["ENSRNOG00000066846",1,0.083026661,16,1.029287011,0.080664246,-3.631926844,0.000350629,0.000373972,"down","yes","ENSRNOG00000066846","lncRNA","chr6:31355072-31362028:-",".",".",".",".","gi|77020598|gb|AC117236.4|",703,0,"Mus musculus BAC clone RP23-416K18 from chromosome 12, complete sequence",".",".",".",".",".",".",".",".","pfam05109","Herpes_BLLF1","Herpes virus major outer envelope glycoprotein (BLLF1). This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralizing antibodies in vivo.",".",".",".",".","."]
["ENSRNOG00000013953",0,0.04151333,14,0.900626135,0.046093855,-4.439281766,0.000380101,0.000403789,"down","yes","Ntrk1","protein_coding","chr2:173236963-173253770:-","gi|11024666|ref|NP_067600.1|",3923,0,"high affinity nerve growth factor receptor precursor [Rattus norvegicus]","gi|11024665|ref|NM_021589.1|",2617,0,"Rattus norvegicus neurotrophic tyrosine kinase, receptor, type 1 (Ntrk1), mRNA","P35739",1515,0,"High affinity nerve growth factor receptor",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001934|positive regulation of protein phosphorylation;GO:0006468|protein phosphorylation;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007178|transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0007275|multicellular organism development;GO:0007399|nervous system development;GO:0007411|axon guidance;GO:0007568|aging;GO:0007611|learning or memory;GO:0007623|circadian rhythm;GO:0008285|negative regulation of cell proliferation;GO:0009314|response to radiation;GO:0009410|response to xenobiotic stimulus;GO:0010623|programmed cell death involved in cell development;GO:0010976|positive regulation of neuron projection development;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0014823|response to activity;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0019233|sensory perception of pain;GO:0021553|olfactory nerve development;GO:0030183|B cell differentiation;GO:0031175|neuron projection development;GO:0031667|response to nutrient levels;GO:0033674|positive regulation of kinase activity;GO:0035094|response to nicotine;GO:0038083|peptidyl-tyrosine autophosphorylation;GO:0038179|neurotrophin signaling pathway;GO:0038180|nerve growth factor signaling pathway;GO:0042490|mechanoreceptor differentiation;GO:0043068|positive regulation of programmed cell death;GO:0043410|positive regulation of MAPK cascade;GO:0043524|negative regulation of neuron apoptotic process;GO:0043547|positive regulation of GTPase activity;GO:0045471|response to ethanol;GO:0045766|positive regulation of angiogenesis;GO:0046579|positive regulation of Ras protein signal transduction;GO:0046777|protein autophosphorylation;GO:0048011|neurotrophin TRK receptor signaling pathway;GO:0048013|ephrin receptor signaling pathway;GO:0048485|sympathetic nervous system development;GO:0048666|neuron development;GO:0048678|response to axon injury;GO:0050965|detection of temperature stimulus involved in sensory perception of pain;GO:0050966|detection of mechanical stimulus involved in sensory perception of pain;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051599|response to hydrostatic pressure;GO:0051602|response to electrical stimulus;GO:0051896|regulation of protein kinase B signaling;GO:0051965|positive regulation of synapse assembly;GO:0051968|positive regulation of synaptic transmission, glutamatergic;GO:0060009|Sertoli cell development;GO:0060384|innervation;GO:0060385|axonogenesis involved in innervation;GO:0061368|behavioral response to formalin induced pain;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071316|cellular response to nicotine;GO:0071363|cellular response to growth factor stimulus;GO:1901215|negative regulation of neuron death;GO:1990090|cellular response to nerve growth factor stimulus;","GO:0000139|Golgi membrane;GO:0005737|cytoplasm;GO:0005769|early endosome;GO:0005770|late endosome;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0030424|axon;GO:0030425|dendrite;GO:0031410|cytoplasmic vesicle;GO:0031901|early endosome membrane;GO:0031902|late endosome membrane;GO:0032991|protein-containing complex;GO:0043025|neuronal cell body;GO:0043235|receptor complex;GO:0055037|recycling endosome;GO:0055038|recycling endosome membrane;","GO:0004675|transmembrane receptor protein serine/threonine kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0005004|GPI-linked ephrin receptor activity;GO:0005030|neurotrophin receptor activity;GO:0005166|neurotrophin p75 receptor binding;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0010465|nerve growth factor receptor activity;GO:0019900|kinase binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0043121|neurotrophin binding;GO:0048406|nerve growth factor binding;","K03176","NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]"]
["ENSRNOG00000046280",0,0.04151333,14,0.900626135,0.046093855,-4.439281766,0.000380101,0.000403789,"down","yes","Tceal5","protein_coding","chrX:99204429-99207353:-","gi|148691903|gb|EDL23850.1|",723,{"v":2E-90,"d":"2.00E-90"},"transcription elongation factor A (SII)-like 5, partial [Mus musculus]","gi|672032616|ref|XM_006227465.2|",1169,0,"PREDICTED: Rattus norvegicus transcription elongation factor A (SII)-like 5 (Tceal5), transcript variant X1, mRNA","Q8CCT4",270,{"v":2E-87,"d":"2.00E-87"},"Transcription elongation factor A protein-like 5",".",".",".",".","pfam04538","BEX","Brain expressed X-linked like family. This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.",".","GO:0005634|nucleus;","GO:0050699|WW domain binding;",".","."]
["ENSRNOG00000067908",0,0.04151333,14,0.900626135,0.046093855,-4.439281766,0.000380101,0.000403789,"down","yes","Gadl1","protein_coding","chr8:115605873-115784410:+","gi|109485549|ref|XP_001076997.1|",3169,0,"PREDICTED: glutamate decarboxylase-like protein 1 isoform X1 [Rattus norvegicus]","gi|564310763|ref|XM_001076997.4|",2348,0,"PREDICTED: Rattus norvegicus glutamate decarboxylase-like 1 (Gadl1), transcript variant X1, mRNA","Q80WP8",1015,0,"Acidic amino acid decarboxylase GADL1","BH2623",205,{"v":1E-56,"d":"1.00E-56"},"COG0076","pfam00282","Pyridoxal_deC","Pyridoxal-dependent decarboxylase conserved domain.",".",".",".",".","."]
["ENSRNOG00000070829",0,0.04151333,14,0.900626135,0.046093855,-4.439281766,0.000380101,0.000403789,"down","yes","ENSRNOG00000070829","lncRNA","chr4:118778737-118786092:-","gi|149036607|gb|EDL91225.1|",455,{"v":5E-53,"d":"5.00E-53"},"rCG56442 [Rattus norvegicus]","gi|62079335|gb|AC155947.8|",154,{"v":7e-73,"d":"7.00E-73"},"Mus musculus 6 BAC RP24-417N21 (Roswell Park Cancer Institute (C57BL/6J Male) Mouse BAC Library) complete sequence","P46935",53.1,2e-06,"E3 ubiquitin-protein ligase NEDD4",".",".",".",".","pfam15262","DUF4592","Domain of unknown function (DUF4592). This protein family is a domain of unknown function, which lies to the N-terminus of the protein. This domain family is found in eukaryotes, and is typically between 114 and 130 amino acids in length. There are two completely conserved residues (L and A) that may be functionally important. In humans, the gene that encodes this protein lies in the position, chromosome 2 open reading frame 55.",".",".",".",".","."]
["ENSRNOG00000017246",8,0.664213284,35,2.251565336,0.295000671,-1.761209861,0.000391919,0.000415722,"down","yes","Adad1","protein_coding","chr2:119948926-120005913:+","gi|564336241|ref|XP_006232340.1|",2998,0,"PREDICTED: adenosine deaminase domain-containing protein 1 isoform X1 [Rattus norvegicus]","gi|672042074|ref|XM_006232278.2|",2037,0,"PREDICTED: Rattus norvegicus adenosine deaminase domain containing 1 (testis specific) (Adad1), transcript variant X1, mRNA","Q3KR54",1119,0,"Adenosine deaminase domain-containing protein 1",".",".",".",".","pfam02137","A_deamin","Adenosine-deaminase (editase) domain. Adenosine deaminases acting on RNA (ADARs) can deaminate adenosine to form inosine. In long double-stranded RNA, this process is non-specific; it occurs site-specifically in RNA transcripts. The former is important in defence against viruses, whereas the latter may affect splicing or untranslated regions. They are primarily nuclear proteins, but a longer isoform of ADAR1 is found predominantly in the cytoplasm. ADARs are derived from the Tad1-like tRNA deaminases that are present across eukaryotes. These in turn belong to the nucleotide/nucleic acid deaminase superfamily and are characterized by a distinct insert between the two conserved cysteines that are involved in binding zinc.","GO:0006382|adenosine to inosine editing;GO:0006396|RNA processing;GO:0007286|spermatid development;","GO:0005634|nucleus;GO:0005730|nucleolus;GO:0005737|cytoplasm;","GO:0003723|RNA binding;GO:0003725|double-stranded RNA binding;GO:0003726|double-stranded RNA adenosine deaminase activity;GO:0004000|adenosine deaminase activity;GO:0008251|tRNA-specific adenosine deaminase activity;",".","."]
["ENSRNOG00000009907",4,0.332106642,25,1.608260955,0.206500469,-2.275783034,0.000397659,0.000421251,"down","yes","Mmp8","protein_coding","chr8:4724029-4733520:+","gi|149020725|gb|EDL78530.1|",2517,0,"matrix metallopeptidase 8 [Rattus norvegicus]","gi|160333380|ref|NM_008611.4|",1447,0,"Mus musculus matrix metallopeptidase 8 (Mmp8), mRNA","O88766",971,0,"Neutrophil collagenase","MA4674",50.4,4e-06,"COG5549","pfam00413","Peptidase_M10","Matrixin. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.","GO:0001503|ossification;GO:0006508|proteolysis;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0030198|extracellular matrix organization;GO:0030574|collagen catabolic process;GO:0032693|negative regulation of interleukin-10 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0035987|endodermal cell differentiation;GO:0043388|positive regulation of DNA binding;GO:0043410|positive regulation of MAPK cascade;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0046330|positive regulation of JNK cascade;GO:0150078|positive regulation of neuroinflammatory response;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1903428|positive regulation of reactive oxygen species biosynthetic process;GO:1903980|positive regulation of microglial cell activation;","GO:0005615|extracellular space;GO:0031012|extracellular matrix;","GO:0004175|endopeptidase activity;GO:0004222|metalloendopeptidase activity;GO:0004252|serine-type endopeptidase activity;GO:0005509|calcium ion binding;GO:0008233|peptidase activity;GO:0008237|metallopeptidase activity;GO:0008270|zinc ion binding;","K01402","MMP8; matrix metalloproteinase-8 (neutrophil collagenase) [EC:3.4.24.34]"]
["ENSRNOG00000017027",4,0.332106642,25,1.608260955,0.206500469,-2.275783034,0.000397659,0.000421251,"down","yes","Adam2","protein_coding","chr15:40242783-40283952:-","gi|149030319|gb|EDL85375.1|",3744,0,"a disintegrin and metalloprotease domain 2 [Rattus norvegicus]","gi|9910119|ref|NM_020077.1|",2409,0,"Rattus norvegicus ADAM metallopeptidase domain 2 (Adam2), mRNA","Q63202",1439,0,"Disintegrin and metalloproteinase domain-containing protein 2",".",".",".",".","pfam01421","Reprolysin","Reprolysin (M12B) family zinc metalloprotease. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as human ADAM8 and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.","GO:0006508|proteolysis;GO:0007155|cell adhesion;GO:0007229|integrin-mediated signaling pathway;GO:0007283|spermatogenesis;GO:0007338|single fertilization;GO:0007339|binding of sperm to zona pellucida;GO:0008542|visual learning;GO:0008584|male gonad development;GO:0010628|positive regulation of gene expression;GO:0030534|adult behavior;","GO:0001669|acrosomal vesicle;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0032991|protein-containing complex;","GO:0003674|molecular_function;GO:0004222|metalloendopeptidase activity;","K06833","ADAM2; disintegrin and metalloproteinase domain-containing protein 2 [EC:3.4.24.-]"]
["ENSRNOG00000068476",4,0.332106642,25,1.608260955,0.206500469,-2.275783034,0.000397659,0.000421251,"down","yes","RGD1560314","protein_coding","chr7:12164922-12180383:-","gi|672058091|ref|XP_008763411.1|",3444,0,"PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 14 isoform X2 [Rattus norvegicus]","gi|672058090|ref|XM_008765189.1|",2914,0,"PREDICTED: Rattus norvegicus RGD1560314 (RGD1560314), transcript variant X2, mRNA","A2VDQ7",445,{"v":3e-141,"d":"3.00E-141"},"Zinc finger protein 420",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000070022",4,0.332106642,25,1.608260955,0.206500469,-2.275783034,0.000397659,0.000421251,"down","yes","ENSRNOG00000070022","lncRNA","chr7:17177556-17192039:-","gi|149031650|gb|EDL86613.1|",173,{"v":1e-11,"d":"1.00E-11"},"similar to hypothetical protein 4930509O22 [Rattus norvegicus]","gi|672058333|ref|XM_008765270.1|",3610,0,"PREDICTED: Rattus norvegicus similar to hypothetical protein 4930509O22 (RGD1566251), transcript variant X4, mRNA",".",".",".",".",".",".",".",".","pfam07313","DUF1460","Protein of unknown function (DUF1460). This family consists of several hypothetical bacterial proteins of around 260 residues in length. The function of this family is unknown.",".",".",".",".","."]
["ENSRNOG00000010696",14,1.162373247,48,3.087861033,0.376433147,-1.409534422,0.000412808,0.000436142,"down","yes","Neil2","protein_coding","chr15:37445381-37454863:-","gi|157822593|ref|NP_001100740.1|",1675,0,"endonuclease 8-like 2 [Rattus norvegicus]","gi|157822592|ref|NM_001107270.1|",1042,0,"Rattus norvegicus nei-like DNA glycosylase 2 (Neil2), mRNA","Q6R2P8",583,0,"Endonuclease 8-like 2",".",".",".",".","pfam06831","H2TH","Formamidopyrimidine-DNA glycosylase H2TH domain. Formamidopyrimidine-DNA glycosylase (Fpg) is a DNA repair enzyme that excises oxidized purines from damaged DNA. This family is the central domain containing the DNA-binding helix-two turn-helix domain.","GO:0006284|base-excision repair;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0015630|microtubule cytoskeleton;GO:0043231|intracellular membrane-bounded organelle;GO:0072686|mitotic spindle;","GO:0003684|damaged DNA binding;GO:0003906|DNA-(apurinic or apyrimidinic site) endonuclease activity;GO:0008017|microtubule binding;GO:0008270|zinc ion binding;GO:0019104|DNA N-glycosylase activity;GO:0140078|class I DNA-(apurinic or apyrimidinic site) endonuclease activity;","K10568","NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]"]
["ENSRNOG00000010758",14,1.162373247,48,3.087861033,0.376433147,-1.409534422,0.000412808,0.000436142,"down","yes","Lpar2","protein_coding","chr16:19595655-19599998:-","gi|40254539|ref|NP_064412.2|",1379,0,"lysophosphatidic acid receptor 2 [Mus musculus]","gi|157818488|ref|NM_001109109.1|",1612,0,"Rattus norvegicus lysophosphatidic acid receptor 2 (Lpar2), mRNA","Q9HBW0",505,{"v":4E-175,"d":"4.00E-175"},"Lysophosphatidic acid receptor 2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0019222|regulation of metabolic process;GO:0035025|positive regulation of Rho protein signal transduction;GO:0043410|positive regulation of MAPK cascade;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0030139|endocytic vesicle;GO:0098978|glutamatergic synapse;GO:0099059|integral component of presynaptic active zone membrane;","GO:0004930|G protein-coupled receptor activity;GO:0030165|PDZ domain binding;GO:0070915|lysophosphatidic acid receptor activity;","K04291","LPAR2, EDG4; lysophosphatidic acid receptor 2"]
["ENSRNOG00000028619",14,1.162373247,48,3.087861033,0.376433147,-1.409534422,0.000412808,0.000436142,"down","yes","Hoxc8","protein_coding","chr7:134127913-134130503:+","gi|471366946|ref|XP_004374005.1|",1184,{"v":1e-159,"d":"1.00E-159"},"PREDICTED: homeobox protein Hox-C8 [Trichechus manatus latirostris]","gi|309319782|ref|NM_001177326.2|",1228,0,"Rattus norvegicus homeobox C8 (Hoxc8), mRNA","P09025",460,{"v":7e-161,"d":"7.00E-161"},"Homeobox protein Hox-C8",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;GO:0009952|anterior/posterior pattern specification;GO:0030182|neuron differentiation;GO:0048705|skeletal system morphogenesis;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0015630|microtubule cytoskeleton;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09308","HOX_8; homeobox protein HoxB/C/D8"]
["ENSRNOG00000023920",2,0.166053321,19,1.222278326,0.135855572,-2.879854357,0.000433577,0.000456502,"down","yes","Zfp791","protein_coding","chr19:23018918-23033504:+","gi|672031152|ref|XP_008772431.1|",2948,0,"PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 791-like isoform X1 [Rattus norvegicus]","gi|672084603|ref|XM_008772433.1|",1746,0,"PREDICTED: Rattus norvegicus rCG51614-like (LOC100363196), transcript variant X3, mRNA","Q5REI6",758,0,"Zinc finger protein 791",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000052510",2,0.166053321,19,1.222278326,0.135855572,-2.879854357,0.000433577,0.000456502,"down","yes","Wnt10a","protein_coding","chr9:76349931-76362400:+","gi|157817686|ref|NP_001101697.1|",1848,0,"protein Wnt-10a precursor [Rattus norvegicus]","gi|157817685|ref|NM_001108227.1|",2456,0,"Rattus norvegicus wingless-type MMTV integration site family, member 10A (Wnt10a), mRNA","P70701",707,0,"Protein Wnt-10a",".",".",".",".","pfam00110","wnt","wnt family. Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.","GO:0001942|hair follicle development;GO:0008150|biological_process;GO:0010628|positive regulation of gene expression;GO:0014033|neural crest cell differentiation;GO:0030182|neuron differentiation;GO:0031069|hair follicle morphogenesis;GO:0042476|odontogenesis;GO:0042487|regulation of odontogenesis of dentin-containing tooth;GO:0043586|tongue development;GO:0043588|skin development;GO:0045165|cell fate commitment;GO:0048730|epidermis morphogenesis;GO:0048733|sebaceous gland development;GO:0060070|canonical Wnt signaling pathway;GO:0071560|cellular response to transforming growth factor beta stimulus;","GO:0005575|cellular_component;GO:0005615|extracellular space;","GO:0003674|molecular_function;GO:0005109|frizzled binding;GO:0005125|cytokine activity;GO:0048018|receptor ligand activity;","K01357","WNT10; wingless-type MMTV integration site family, member 10"]
["ENSRNOG00000062559",2,0.166053321,19,1.222278326,0.135855572,-2.879854357,0.000433577,0.000456502,"down","yes","ENSRNOG00000062559","lncRNA","chr18:27470677-27474178:+",".",".",".",".","gi|625276646|ref|XM_007631761.1|",71,{"v":4e-27,"d":"4.00E-27"},"PREDICTED: Cricetulus griseus collagen alpha-1(III) chain-like (LOC103162556), mRNA",".",".",".",".",".",".",".",".","pfam15268","Dapper","Dapper. This is a family of signalling proteins. They act in a diverse range of signaling pathways and have a range of binding partners. They act as homo- and heterodimers.",".",".",".",".","."]
["ENSRNOG00000066392",2,0.166053321,19,1.222278326,0.135855572,-2.879854357,0.000433577,0.000456502,"down","yes","ENSRNOG00000066392","lncRNA","chr4:62593370-62597292:+",".",".",".",".","gi|62988373|gb|AC153817.6|",663,0,"Mus musculus BAC RP23-11P24 (Roswell Park Cancer Institute (C57BL/6J Female) Mouse BAC Library) complete sequence",".",".",".",".",".",".",".",".","pfam03849","Tfb2","Transcription factor Tfb2.",".",".",".",".","."]
["ENSRNOG00000016835",3,0.249079982,22,1.41526964,0.175994718,-2.506395962,0.000438644,0.000461532,"down","yes","Sycp1","protein_coding","chr2:190296954-190456737:-","gi|149030467|gb|EDL85504.1|",4558,0,"synaptonemal complex protein 1, isoform CRA_a [Rattus norvegicus]","gi|6981615|ref|NM_012810.1|",3230,0,"Rattus norvegicus synaptonemal complex protein 1 (Sycp1), mRNA","Q03410",1756,0,"Synaptonemal complex protein 1",".",".",".",".","pfam05483","SCP-1","Synaptonemal complex protein 1 (SCP-1). Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.","GO:0000711|meiotic DNA repair synthesis;GO:0007129|synapsis;GO:0007130|synaptonemal complex assembly;GO:0007131|reciprocal meiotic recombination;GO:0007283|spermatogenesis;GO:0032880|regulation of protein localization;GO:0035092|sperm chromatin condensation;GO:0051026|chiasma assembly;GO:0051289|protein homotetramerization;GO:0051301|cell division;GO:0051878|lateral element assembly;","GO:0000775|chromosome, centromeric region;GO:0000794|condensed nuclear chromosome;GO:0000795|synaptonemal complex;GO:0000801|central element;GO:0000802|transverse filament;GO:0001673|male germ cell nucleus;GO:0005634|nucleus;GO:0005694|chromosome;","GO:0003690|double-stranded DNA binding;","K19533","SYCP1; synaptonemal complex protein 1"]
["ENSRNOG00000046547",3,0.249079982,22,1.41526964,0.175994718,-2.506395962,0.000438644,0.000461532,"down","yes","Rbm24","protein_coding","chr17:18275688-18288102:-","gi|300797848|ref|NP_001178029.1|",937,{"v":9e-115,"d":"9.00E-115"},"RNA-binding protein 24 [Rattus norvegicus]","gi|300797847|ref|NM_001191100.1|",2604,0,"Rattus norvegicus RNA binding motif protein 24 (Rbm24), mRNA","D3Z4I3",362,{"v":3e-115,"d":"3.00E-115"},"RNA-binding protein 24","TP0356",60.5,1e-09,"COG0724","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0000381|regulation of alternative mRNA splicing, via spliceosome;GO:0003197|endocardial cushion development;GO:0006974|cellular response to DNA damage stimulus;GO:0010830|regulation of myotube differentiation;GO:0010831|positive regulation of myotube differentiation;GO:0043488|regulation of mRNA stability;GO:0048255|mRNA stabilization;GO:0061157|mRNA destabilization;GO:0061158|3'-UTR-mediated mRNA destabilization;GO:1902811|positive regulation of skeletal muscle fiber differentiation;GO:1905870|positive regulation of 3'-UTR-mediated mRNA stabilization;GO:2000738|positive regulation of stem cell differentiation;GO:2000766|negative regulation of cytoplasmic translation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0003730|mRNA 3'-UTR binding;GO:0035925|mRNA 3'-UTR AU-rich region binding;GO:0097157|pre-mRNA intronic binding;GO:1990715|mRNA CDS binding;GO:1990825|sequence-specific mRNA binding;","K25006","RBM24_38; RNA-binding protein 24/38"]
["ENSRNOG00000069755",9,0.747239945,37,2.380226213,0.313936524,-1.671455208,0.000441725,0.000464469,"down","yes","Np4","protein_coding","chr16:70342529-70497202:-","gi|564389779|ref|XP_006253428.1|",564,{"v":5E-71,"d":"5.00E-71"},"PREDICTED: neutrophil antibiotic peptide NP-4 isoform X1 [Rattus norvegicus]","gi|564389778|ref|XM_006253366.1|",435,0,"PREDICTED: Rattus norvegicus defensin NP-4 precursor (Np4), transcript variant X1, mRNA","Q62714",158,{"v":5e-48,"d":"5.00E-48"},"Neutrophil antibiotic peptide NP-4",".",".",".",".","pfam00879","Defensin_propep","Defensin propeptide.",".",".",".",".","."]
["ENSRNOG00000000918",28,2.324746495,75,4.824782864,0.481834429,-1.053390612,0.000449329,0.000471844,"down","yes","Zbed5","protein_coding","chr12:26807600-26813664:-","gi|157786908|ref|NP_001099394.1|",3734,0,"coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial [Rattus norvegicus]","gi|157786907|ref|NM_001105924.1|",2445,0,"Rattus norvegicus zinc finger, BED-type containing 5 (Zbed5), mRNA","A4Z943",414,{"v":5e-131,"d":"5.00E-131"},"Zinc finger BED domain-containing protein 5",".",".",".",".","pfam06747","CHCH","CHCH domain. we have identified a conserved motif in the LOC118487 protein that we have called the CHCH motif. Alignment of this protein with related members showed the presence of three subgroups of proteins, which are called the S (Small), N (N-terminal extended) and C (C-terminal extended) subgroups. All three sub-groups of proteins have in common that they contain a predicted conserved [coiled coil 1]-[helix 1]-[coiled coil 2]-[helix 2] domain (CHCH domain). Within each helix of the CHCH domain, there are two cysteines present in a C-X9-C motif. The N-group contains an additional double helix domain, and each helix contains the C-X9-C motif. This family contains a number of characterized proteins: Cox19 protein - a nuclear gene of Saccharomyces cerevisiae, codes for an 11-kDa protein (Cox19p) required for expression of cytochrome oxidase. Because cox19 mutants are able to synthesize the mitochondrial and nuclear gene products of cytochrome oxidase, Cox19p probably functions post-translationally during assembly of the enzyme. Cox19p is present in the cytoplasm and mitochondria, where it exists as a soluble intermembrane protein. This dual location is similar to what was previously reported for Cox17p, a low molecular weight copper protein thought to be required for maturation of the CuA centre of subunit 2 of cytochrome oxidase. Cox19p have four conserved potential metal ligands, these are three cysteines and one histidine. Mrp10 - belongs to the class of yeast mitochondrial ribosomal proteins that are essential for translation. Eukaryotic NADH-ubiquinone oxidoreductase 19 kDa (NDUFA8) subunit. The CHCH domain was previously called DUF657.",".",".",".","K24642","ZBED5_7_8_9, BUSTER; zinc finger BED domain-containing protein 5/7/8/9"]
["ENSRNOG00000069767",28,2.324746495,75,4.824782864,0.481834429,-1.053390612,0.000449329,0.000471844,"down","yes","Vom2r6","protein_coding","chr1:1161832-1224262:+","gi|153791928|ref|NP_001092929.1|",4360,0,"vomeronasal 2 receptor 6 precursor [Rattus norvegicus]","gi|153791927|ref|NM_001099459.1|",2526,0,"Rattus norvegicus vomeronasal 2 receptor, 6 (Vom2r6), mRNA","E9Q6I0",809,0,"Vomeronasal type-2 receptor 116",".",".",".",".","pfam02994","Transposase_22","L1 transposable element.",".",".",".",".","."]
["ENSRNOG00000062597",10,0.830266605,39,2.508887089,0.330930239,-1.595400968,0.000484717,0.00050651,"down","yes","ENSRNOG00000062597","lncRNA","chr7:25678448-25680098:+",".",".",".",".","gi|672021530|ref|XR_601677.1|",988,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103692821 (LOC103692821), ncRNA",".",".",".",".",".",".",".",".","pfam09551","Spore_II_R","Stage II sporulation protein R (spore_II_R). SpoIIR is designated stage II sporulation protein R. A comparative genome analysis of all sequenced genomes of Firmicutes shows that the proteins are strictly conserved among the sub-set of endospore-forming species. SpoIIR is a signalling protein that links the activation of sigma E to the transcriptional activity of sigma F during sporulation.",".",".",".",".","."]
["ENSRNOG00000068600",25,2.075666513,69,4.438800235,0.467618817,-1.096595111,0.000505364,0.000526622,"down","yes","ENSRNOG00000068600","protein_coding","chr2:136282917-136284328:+","gi|578808863|ref|XP_006714189.1|",1047,{"v":5e-142,"d":"5.00E-142"},"PREDICTED: eukaryotic translation initiation factor 4E isoform X1 [Homo sapiens]","gi|672044159|ref|XM_008761488.1|",573,0,"PREDICTED: Rattus norvegicus eukaryotic translation initiation factor 4E (Eif4e), transcript variant X1, mRNA","P63074",405,{"v":3e-143,"d":"3.00E-143"},"Eukaryotic translation initiation factor 4E","SPAC16E8.15",137,{"v":1e-38,"d":"1.00E-38"},"COG5053","pfam01652","IF4E","Eukaryotic initiation factor 4E.",".",".",".",".","."]
["ENSRNOG00000068340",7,0.581186624,32,2.058574022,0.282324861,-1.824571922,0.000513283,0.000534351,"down","yes","ENSRNOG00000068340","lncRNA","chr4:117675777-117682519:+","gi|564303945|ref|XP_006225032.1|",494,{"v":2E-55,"d":"2.00E-55"},"PREDICTED: uncharacterized protein LOC102554508 [Rattus norvegicus]","gi|672050314|ref|XR_353419.2|",736,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102554796 (LOC102554796), transcript variant X3, ncRNA",".",".",".",".",".",".",".",".","pfam15499","Peptidase_C98","Ubiquitin-specific peptidase-like, SUMO isopeptidase. Peptidase_C98 is a small family of SUMO - small ubiquitin-related modifier - isopeptidases found in eukaryotes. Reversible attachment of SUMO is an essential protein modification in all eukaryotic cells, The family neither binds nor cleaves ubiquitin, but is a potent SUMO isopeptidase, and the invariant residues required for SUMO binding and cleavage, in UniProtKB:Q5W0Q7, are Cys-236, His-456 and Asp-472, all of which are fully conserved in the family. Member proteins are low-abundance proteins that colocalize with coilin in Cajal bodies. Peptidase_C98 depletion does not affect global sumoylation, but causes striking coilin mis-localisation and impairs cell proliferation, functions that are not dependent on the catalytic activity. Thus, Peptidase_C98 represents a third type of SUMO protease, with essential functions in Cajal body biology.",".",".",".",".","."]
["ENSRNOG00000014971",5,0.415133303,27,1.736921831,0.239005173,-2.064886251,5.32611E-4,0.000553302,"down","yes","Mas1","protein_coding","chr1:47880309-47911709:+","gi|6981186|ref|NP_036889.1|",1574,0,"proto-oncogene Mas [Rattus norvegicus]","gi|672034271|ref|XM_006227860.2|",1879,0,"PREDICTED: Rattus norvegicus MAS1 proto-oncogene, G protein-coupled receptor (Mas1), transcript variant X1, mRNA","P12526",610,0,"Proto-oncogene Mas",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001933|negative regulation of protein phosphorylation;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007250|activation of NF-kappaB-inducing kinase activity;GO:0007283|spermatogenesis;GO:0008284|positive regulation of cell proliferation;GO:0008584|male gonad development;GO:0009410|response to xenobiotic stimulus;GO:0014823|response to activity;GO:0021766|hippocampus development;GO:0034698|response to gonadotropin;GO:0038166|angiotensin-activated signaling pathway;GO:0043434|response to peptide hormone;GO:0045740|positive regulation of DNA replication;GO:0050727|regulation of inflammatory response;GO:0060732|positive regulation of inositol phosphate biosynthetic process;GO:0070528|protein kinase C signaling;GO:0071375|cellular response to peptide hormone stimulus;","GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0001595|angiotensin receptor activity;GO:0004930|G protein-coupled receptor activity;GO:0042277|peptide binding;","K04303","MAS1; proto-oncogene Mas"]
["ENSRNOG00000020136",12,0.996319926,43,2.766208842,0.360175237,-1.473229098,0.00054936,0.000569037,"down","yes","Tgm1","protein_coding","chr15:29191041-29204523:-","gi|13928912|ref|NP_113847.1|",3950,0,"protein-glutamine gamma-glutamyltransferase K [Rattus norvegicus]","gi|672078098|ref|XM_006252014.2|",2644,0,"PREDICTED: Rattus norvegicus transglutaminase 1 (Tgm1), transcript variant X1, mRNA","P23606",1516,0,"Protein-glutamine gamma-glutamyltransferase K",".",".",".",".","pfam00868","Transglut_N","Transglutaminase family.","GO:0009887|animal organ morphogenesis;GO:0010838|positive regulation of keratinocyte proliferation;GO:0018149|peptide cross-linking;GO:0030216|keratinocyte differentiation;GO:0031424|keratinization;GO:0045787|positive regulation of cell cycle;","GO:0005575|cellular_component;GO:0005912|adherens junction;GO:0016020|membrane;GO:0031224|intrinsic component of membrane;","GO:0003810|protein-glutamine gamma-glutamyltransferase activity;GO:0042802|identical protein binding;GO:0046872|metal ion binding;","K05619","TGM1; transglutaminase 1 [EC:2.3.2.13]"]
["ENSRNOG00000052802",19,1.57750655,57,3.666834977,0.430209311,-1.216889345,0.000591613,0.000608662,"down","yes","Aldoa","protein_coding","chr1:181402275-181406182:-","gi|564330881|ref|XP_006230271.1|",2133,0,"PREDICTED: fructose-bisphosphate aldolase A isoform X2 [Rattus norvegicus]","gi|672038361|ref|XM_006230210.2|",1545,0,"PREDICTED: Rattus norvegicus aldolase A, fructose-bisphosphate (Aldoa), transcript variant X1, mRNA","P05065",715,0,"Fructose-bisphosphate aldolase A","AGl2190",323,{"v":8e-105,"d":"8.00E-105"},"COG3588","pfam00274","Glycolytic","Fructose-bisphosphate aldolase class-I.","GO:0001666|response to hypoxia;GO:0006000|fructose metabolic process;GO:0006096|glycolytic process;GO:0006754|ATP biosynthetic process;GO:0006941|striated muscle contraction;GO:0007339|binding of sperm to zona pellucida;GO:0008360|regulation of cell shape;GO:0009408|response to heat;GO:0019242|methylglyoxal biosynthetic process;GO:0030335|positive regulation of cell migration;GO:0030388|fructose 1,6-bisphosphate metabolic process;GO:0032496|response to lipopolysaccharide;GO:0035094|response to nicotine;GO:0043627|response to estrogen;GO:0046716|muscle cell cellular homeostasis;GO:0051289|protein homotetramerization;","GO:0000792|heterochromatin;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0015629|actin cytoskeleton;GO:0016020|membrane;GO:0030018|Z disc;GO:0031430|M band;GO:0032991|protein-containing complex;GO:0035686|sperm fibrous sheath;GO:0061827|sperm head;GO:0070062|extracellular exosome;","GO:0002020|protease binding;GO:0003674|molecular_function;GO:0004332|fructose-bisphosphate aldolase activity;GO:0005515|protein binding;GO:0008092|cytoskeletal protein binding;GO:0042802|identical protein binding;GO:0070061|fructose binding;","K01623","ALDO; fructose-bisphosphate aldolase, class I [EC:4.1.2.13]"]
["ENSRNOG00000069297",15,1.245399908,49,3.152191471,0.395090184,-1.339746092,5.97056E-4,0.000613867,"down","yes","ENSRNOG00000069297","lncRNA","chr4:125686239-125714068:+",".",".",".",".","gi|33285454|gb|AC122015.3|",393,0,"Mus musculus BAC clone RP24-358M18 from chromosome 6, complete sequence",".",".",".",".",".",".",".",".","pfam02935","COX7C","Cytochrome c oxidase subunit VIIc. Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of cytochrome c oxidase subunit VIIc. The yeast member of this family is called COX VIII.",".",".",".",".","."]
["ENSRNOG00000064037",1,0.083026661,15,0.964956573,0.086041862,-3.538817439,0.000609591,0.000625146,"down","yes","Hpse2","protein_coding","chr1:241583187-242246118:-","gi|672040510|ref|XP_008758667.1|",2528,0,"PREDICTED: inactive heparanase-2 isoform X1 [Rattus norvegicus]","gi|672040509|ref|XM_008760445.1|",2378,0,"PREDICTED: Rattus norvegicus heparanase 2 (Hpse2), transcript variant X1, mRNA","B2RY83",962,0,"Inactive heparanase-2",".",".",".",".","pfam03662","Glyco_hydro_79n","Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesized as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumor cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity.",".",".",".",".","."]
["ENSRNOG00000064890",1,0.083026661,15,0.964956573,0.086041862,-3.538817439,0.000609591,0.000625146,"down","yes","ENSRNOG00000064890","pseudogene","chr14:46603666-46604536:-","gi|612002131|ref|XP_007485990.1|",556,{"v":2E-66,"d":"2.00E-66"},"PREDICTED: transformer-2 protein homolog beta-like isoform X1 [Monodelphis domestica]","gi|672076320|ref|XR_359545.2|",703,0,"PREDICTED: Rattus norvegicus similar to splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) (LOC685935), transcript variant X2, misc_RNA","P62997",213,{"v":4e-66,"d":"4.00E-66"},"Transformer-2 protein homolog beta",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.",".",".",".",".","."]
["ENSRNOG00000015259",6,0.498159963,29,1.865582707,0.267026469,-1.904945338,0.000662108,0.000675321,"down","yes","Pth2r","protein_coding","chr9:66706050-66810036:+","gi|149045964|gb|EDL98857.1|",2790,0,"parathyroid hormone receptor 2, isoform CRA_a [Rattus norvegicus]","gi|451958082|ref|NM_031089.2|",1960,0,"Rattus norvegicus parathyroid hormone 2 receptor (Pth2r), mRNA","P70555",1069,0,"Parathyroid hormone 2 receptor",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0007166|cell surface receptor signaling pathway;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007188|adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0120162|positive regulation of cold-induced thermogenesis;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004991|parathyroid hormone receptor activity;GO:0008528|G protein-coupled peptide receptor activity;GO:0017046|peptide hormone binding;","K04586","PTHR2; parathyroid hormone receptor 2"]
["ENSRNOG00000020073",0,0.04151333,13,0.836295696,0.049639536,-4.332366562,0.000663372,0.000676179,"down","yes","Pcdhb8","protein_coding","chr18:29065466-29067805:+","gi|62339302|ref|NP_001014779.1|",3931,0,"protocadherin beta 8 precursor [Rattus norvegicus]","gi|62339301|ref|NM_001014779.1|",2340,0,"Rattus norvegicus protocadherin beta 8 (Pcdhb8), mRNA","Q91XZ2",1397,0,"Protocadherin beta-8",".",".",".",".","pfam08266","Cadherin_2","Cadherin-like. This cadherin domain is usually the most N-terminal copy of the domain.","GO:0007155|cell adhesion;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005887|integral component of plasma membrane;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;GO:0042802|identical protein binding;","K16494","PCDHB; protocadherin beta"]
["ENSRNOG00000070127",0,0.04151333,13,0.836295696,0.049639536,-4.332366562,0.000663372,0.000676179,"down","yes","ENSRNOG00000070127","lncRNA","chr7:22915213-22917124:+",".",".",".",".","gi|672058466|ref|XR_593368.1|",306,{"v":1e-157,"d":"1.00E-157"},"PREDICTED: Rattus norvegicus uncharacterized LOC102554140 (LOC102554140), transcript variant X2, ncRNA",".",".",".",".",".",".",".",".","pfam10036","RLL","Putative carnitine deficiency-associated protein. This family of proteins conserved from nematodes to humans is of approximately 250 amino acids. It is purported to be carnitine deficiency-associated protein but this could not be confirmed. It carries a characteristic RLL sequence-motif. The function is unknown.",".",".",".",".","."]
["ENSRNOG00000017786",3,0.249079982,21,1.350939202,0.184375419,-2.439281766,0.000719681,0.000729852,"down","yes","Acta1","protein_coding","chr19:51883715-51886742:-","gi|625184696|ref|XP_007651673.1|",2064,0,"PREDICTED: actin, alpha skeletal muscle [Cricetulus griseus]","gi|298892557|emb|FQ215282.1|",1445,0,"Rattus norvegicus TL0ACA48YN09 mRNA sequence","P68136",790,0,"Actin, alpha skeletal muscle","SPBC32H8.12c",711,0,"COG5277","pfam00022","Actin","Actin.","GO:0009612|response to mechanical stimulus;GO:0009991|response to extracellular stimulus;GO:0010226|response to lithium ion;GO:0010628|positive regulation of gene expression;GO:0030240|skeletal muscle thin filament assembly;GO:0043503|skeletal muscle fiber adaptation;GO:0048545|response to steroid hormone;GO:0048741|skeletal muscle fiber development;GO:0071417|cellular response to organonitrogen compound;GO:0090131|mesenchyme migration;","GO:0001725|stress fiber;GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005865|striated muscle thin filament;GO:0005869|dynactin complex;GO:0005884|actin filament;GO:0015629|actin cytoskeleton;GO:0030017|sarcomere;GO:0030027|lamellipodium;GO:0030175|filopodium;GO:0044297|cell body;","GO:0005524|ATP binding;","K10354","ACTA1; actin, alpha skeletal muscle"]
["ENSRNOG00000064150",3,0.249079982,21,1.350939202,0.184375419,-2.439281766,0.000719681,0.000729852,"down","yes","ENSRNOG00000064150","lncRNA","chr17:83659433-83682702:+",".",".",".",".","gi|672030333|ref|XR_598232.1|",492,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102550221 (LOC102550221), transcript variant X1, ncRNA",".",".",".",".",".",".",".",".","pfam05875","Ceramidase","Ceramidase. This family consists of several ceramidases. Ceramidases are enzymes involved in regulating cellular levels of ceramides, sphingoid bases, and their phosphates, EC:3.5.1.23.",".",".",".",".","."]
["ENSRNOG00000030318",2,0.166053321,18,1.157947887,0.143403104,-2.801851845,0.000731521,0.000740098,"down","yes","Gpr83","protein_coding","chr8:11693540-11704028:+","gi|17939358|ref|NP_536336.1|",1979,0,"probable G-protein coupled receptor 83 precursor [Rattus norvegicus]","gi|17939357|ref|NM_080411.1|",3565,0,"Rattus norvegicus G protein-coupled receptor 83 (Gpr83), mRNA","P30731",745,0,"Probable G-protein coupled receptor 83",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007218|neuropeptide signaling pathway;GO:0051384|response to glucocorticoid;","GO:0005887|integral component of plasma membrane;GO:0005929|cilium;GO:0097730|non-motile cilium;","GO:0004983|neuropeptide Y receptor activity;GO:0008188|neuropeptide receptor activity;","K04210","GPR83, GPR72; G protein-coupled receptor 83"]
["ENSRNOG00000033136",2,0.166053321,18,1.157947887,0.143403104,-2.801851845,0.000731521,0.000740098,"down","yes","RT1-M5","protein_coding","chr20:1546511-1548775:-","gi|270133009|ref|NP_001161825.1|",1854,0,"RT1 class Ib, locus M5 isoform 1 precursor [Rattus norvegicus]","gi|270133008|ref|NM_001168353.1|",1074,0,"Rattus norvegicus RT1 class Ib, locus M5 (RT1-M5), transcript variant 1, mRNA","P13749",419,{"v":5e-144,"d":"5.00E-144"},"Patr class I histocompatibility antigen, A-126 alpha chain",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.","GO:0001916|positive regulation of T cell mediated cytotoxicity;GO:0002476|antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002486|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0006955|immune response;","GO:0005615|extracellular space;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0005102|signaling receptor binding;GO:0042605|peptide antigen binding;","K06751","MHC1; MHC class I antigen"]
["ENSRNOG00000070517",2,0.166053321,18,1.157947887,0.143403104,-2.801851845,0.000731521,0.000740098,"down","yes","Cesl1","protein_coding","chr19:22670712-22712608:-","gi|66730527|ref|NP_001019536.1|",2871,0,"liver carboxylesterase B-1 precursor [Rattus norvegicus]","gi|66730526|ref|NM_001024365.1|",1820,0,"Rattus norvegicus carboxylesterase-like 1 (Cesl1), mRNA","Q63010",1104,0,"Liver carboxylesterase B-1","BS_pnbA",209,{"v":7e-58,"d":"7.00E-58"},"COG2272","pfam00135","COesterase","Carboxylesterase family.",".",".",".",".","."]
["ENSRNOG00000062880",29,2.407773155,75,4.824782864,0.499042801,-1.002764539,0.000751532,0.000759022,"down","yes","ENSRNOG00000062880","lncRNA","chr2:763810-787844:-",".",".",".",".","gi|564360212|ref|XR_355699.1|",679,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102551151 (LOC102551151), ncRNA",".",".",".",".",".",".",".",".","pfam04247","SirB","Invasion gene expression up-regulator, SirB. SirB up-regulates Salmonella typhimurium invasion gene transcription. It is, however, not essential for the expression of these genes. Its function is unknown.",".",".",".",".","."]
["ENSRNOG00000020105",11,0.913293266,40,2.573217527,0.354922682,-1.49442332,0.000756357,0.000763052,"down","yes","Klhl30","protein_coding","chr9:91942504-91952730:+","gi|293349933|ref|XP_001067145.2|",3056,0,"PREDICTED: kelch-like protein 30 [Rattus norvegicus]","gi|672066084|ref|XM_003750733.2|",2057,0,"PREDICTED: Rattus norvegicus kelch-like family member 30 (Klhl30), mRNA","Q8C3F7",1137,0,"Kelch-like protein 30",".",".",".",".","pfam07707","BACK","BTB And C-terminal Kelch. This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).",".",".",".","K10466","KLHL30; kelch-like protein 30"]
["ENSRNOG00000062945",11,0.913293266,40,2.573217527,0.354922682,-1.49442332,0.000756357,0.000763052,"down","yes","ENSRNOG00000062945","pseudogene","chr11:82504956-82505359:-","gi|148665111|gb|EDK97527.1|",293,{"v":4e-31,"d":"4.00E-31"},"mCG126588, isoform CRA_a, partial [Mus musculus]","gi|53734299|gb|BC083922.1|",386,0,"Rattus norvegicus cDNA clone IMAGE:7135213",".",".",".",".",".",".",".",".","pfam12250","AftA_N","Arabinofuranosyltransferase N terminal. This domain family is found in bacteria, and is typically between 430 and 441 amino acids in length. This family is the N terminal region of AftA. The enzyme catalyses the addition of the first key arabinofuranosyl residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol to the galactan domain of the cell wall, thus priming the galactan for further elaboration by the arabinofuranosyltransferases. The N terminal region has been predicted to span 11 transmembrane regions.",".",".",".",".","."]
["ENSRNOG00000066849",11,0.913293266,40,2.573217527,0.354922682,-1.49442332,0.000756357,0.000763052,"down","yes","RGD1564748","protein_coding","chrX:4755173-4762467:+","gi|672032027|ref|XP_008756584.1|",7400,0,"PREDICTED: collagen alpha-1(III) chain-like isoform X11 [Rattus norvegicus]","gi|672032009|ref|XM_008758354.1|",3616,0,"PREDICTED: Rattus norvegicus similar to Mortality factor 4-like protein 2 (MORF-related gene X protein) (RGD1564748), transcript variant X2, mRNA","Q4R578",256,{"v":2e-74,"d":"2.00E-74"},"Mortality factor 4-like protein 2",".",".",".",".","pfam05712","MRG","MRG. This family consists of three different eukaryotic proteins (mortality factor 4 (MORF4/MRG15), male-specific lethal 3(MSL-3) and ESA1-associated factor 3(EAF3)). It is thought that the MRG family is involved in transcriptional regulation via histone acetylation. It contains 2 chromo domains and a leucine zipper motif.",".",".",".",".","."]
["ENSRNOG00000063293",7,0.581186624,31,1.994243584,0.291432114,-1.778768232,0.000780129,0.000785177,"down","yes","Pdrg1","lncRNA","chr3:141476501-141483858:-","gi|62244083|ref|NP_001014762.1|",540,{"v":3e-61,"d":"3.00E-61"},"p53 and DNA damage-regulated protein 1 [Rattus norvegicus]","gi|86439996|gb|AC129342.5|",1363,0,"Rattus norvegicus BAC CH230-229B21 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q642A0",212,{"v":1E-62,"d":"1.00E-62"},"p53 and DNA damage-regulated protein 1",".",".",".",".","pfam01920","Prefoldin_2","Prefoldin subunit. This family includes prefoldin subunits that are not detected by pfam02996.",".",".",".",".","."]
["ENSRNOG00000012767",20,1.66053321,58,3.731165415,0.445044115,-1.167979744,0.000795196,0.000799209,"down","yes","Micu3","protein_coding","chr16:51925225-52010613:-","gi|564389333|ref|XP_006253262.1|",2519,0,"PREDICTED: calcium uptake protein 3, mitochondrial isoform X1 [Rattus norvegicus]","gi|672080292|ref|XM_006253200.2|",1789,0,"PREDICTED: Rattus norvegicus mitochondrial calcium uptake family, member 3 (Micu3), transcript variant X1, mRNA","Q9CTY5",953,0,"Calcium uptake protein 3, mitochondrial",".",".",".",".","pfam13833","EF-hand_8","EF-hand domain pair.","GO:0036444|calcium import into the mitochondrion;GO:0051560|mitochondrial calcium ion homeostasis;","GO:1990246|uniplex complex;","GO:0005509|calcium ion binding;","K23843","MICU3; calcium uptake protein 3, mitochondrial"]
["ENSRNOG00000065901",19,1.57750655,56,3.602504538,0.43789162,-1.191354252,0.000812525,0.000815216,"down","yes","ENSRNOG00000065901","lncRNA","chr8:59728733-59731278:+",".",".",".",".","gi|113208190|emb|CT025587.11|",317,{"v":2e-163,"d":"2.00E-163"},"Mouse DNA sequence from clone RP23-325P15 on chromosome 9, complete sequence",".",".",".",".",".",".",".",".","pfam10277","Frag1","Frag1/DRAM/Sfk1 family. This family includes Frag1, DRAM and Sfk1 proteins. Frag1 (FGF receptor activating protein 1) is a protein that is conserved from fungi to humans. There are four potential iso-prenylation sites throughout the peptide, viz CILW, CIIW and CIGL. Frag1 is a membrane-spanning protein that is ubiquitously expressed in adult tissues suggesting an important cellular function. Dram is a family of proteins conserved from nematodes to humans with six hydrophobic transmembrane regions and an Endoplasmic Reticulum signal peptide. It is a lysosomal protein that induces macro-autophagy as an effector of p53-mediated death, where p53 is the tumor-suppressor gene that is frequently mutated in cancer. Expression of Dram is stress-induced. This region is also part of a family of small plasma membrane proteins, referred to as Sfk1, that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, thus allowing proper localisation of Stt4p to the actin cytoskeleton.",".",".",".",".","."]
["ENSRNOG00000033177",27,2.241719834,71,4.567461111,0.490802172,-1.026786461,0.000827115,0.000828294,"down","yes","AC118841.1","protein_coding","chr5:68280970-68281345:-","gi|55778620|gb|AAH86595.1|",202,{"v":5e-19,"d":"5.00E-19"},"Cbx3 protein [Rattus norvegicus]","gi|55778619|gb|BC086595.1|",213,{"v":2e-106,"d":"2.00E-106"},"Rattus norvegicus chromobox homolog 3 (HP1 gamma homolog, Drosophila), mRNA (cDNA clone IMAGE:7311933), complete cds","Q5R6X7",54.3,2e-09,"Chromobox protein homolog 3",".",".",".",".","pfam14061","Mtf2_C","Polycomb-like MTF2 factor 2. Mammalian Polycomb-like gene MTF2/PCL2 forms a complex with Polycomb repressive complex-2 (PRC2) and collaborates with PRC1 to achieve repression of Hox gene expression. The human MTF2 gene is expressed in three splicing variants, each of them contains the short C-terminal domain defined here. The domain is subject to structure determination by the Joint Center of Structural Genomics.",".",".",".",".","."]
["ENSRNOG00000070261",14,1.162373247,46,2.959200157,0.392799806,-1.348133878,0.000831288,0.000832343,"down","yes","ENSRNOG00000070261","lncRNA","chr4:162977700-162980187:-","gi|149036607|gb|EDL91225.1|",199,{"v":2E-16,"d":"2.00E-16"},"rCG56442 [Rattus norvegicus]","gi|672018807|ref|XR_600856.1|",446,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102554909 (LOC102554909), transcript variant X1, ncRNA",".",".",".",".",".",".",".",".","pfam14629","ORC4_C","Origin recognition complex (ORC) subunit 4 C-terminus. This entry represents the C-terminus of origin recognition complex subunit 4.",".",".",".",".","."]
["ENSRNOG00000022337",5,0.415133303,26,1.672591393,0.24819768,-2.010438467,0.000835401,0.0008362,"down","yes","Slitrk6","protein_coding","chr15:87563322-87570393:-","gi|157823385|ref|NP_001099527.1|",3858,0,"SLIT and NTRK-like protein 6 precursor [Rattus norvegicus]","gi|157823384|ref|NM_001106057.1|",4248,0,"Rattus norvegicus SLIT and NTRK-like family, member 6 (Slitrk6), mRNA","Q8C110",1431,0,"SLIT and NTRK-like protein 6",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.","GO:0001964|startle response;GO:0002088|lens development in camera-type eye;GO:0002093|auditory receptor cell morphogenesis;GO:0007409|axonogenesis;GO:0007416|synapse assembly;GO:0007601|visual perception;GO:0008344|adult locomotory behavior;GO:0021562|vestibulocochlear nerve development;GO:0031223|auditory behavior;GO:0035264|multicellular organism growth;GO:0042472|inner ear morphogenesis;GO:0043010|camera-type eye development;GO:0048812|neuron projection morphogenesis;GO:0051965|positive regulation of synapse assembly;GO:0060005|vestibular reflex;GO:0060007|linear vestibuloocular reflex;GO:0060384|innervation;GO:0090102|cochlea development;GO:1905606|regulation of presynapse assembly;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0071944|cell periphery;",".",".","."]
["ENSRNOG00000032991",5,0.415133303,26,1.672591393,0.24819768,-2.010438467,0.000835401,0.0008362,"down","yes","Rufy4","protein_coding","chr9:75703750-75723525:+","gi|564311777|ref|XP_006226938.1|",2672,0,"PREDICTED: RUN and FYVE domain-containing protein 4 [Rattus norvegicus]","gi|672065897|ref|XM_006245288.2|",2267,0,"PREDICTED: Rattus norvegicus RUN and FYVE domain containing 4 (Rufy4), mRNA","Q3TYX8",842,0,"RUN and FYVE domain-containing protein 4",".",".",".",".","pfam02759","RUN","RUN domain. This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.","GO:0000045|autophagosome assembly;GO:0016239|positive regulation of macroautophagy;GO:0071353|cellular response to interleukin-4;","GO:0005776|autophagosome;","GO:0032266|phosphatidylinositol-3-phosphate binding;GO:0046872|metal ion binding;",".","."]
["ENSRNOG00000014135",22,1.826586532,61,3.924156729,0.46547237,-1.103232563,1.015918E-3,0.001002606,"down","yes","Rab11fip4","protein_coding","chr10:64550177-64654759:+","gi|157823005|ref|NP_001100493.1|",2913,0,"rab11 family-interacting protein 4 [Rattus norvegicus]","gi|157823004|ref|NM_001107023.1|",3127,0,"Rattus norvegicus RAB11 family interacting protein 4 (class II) (Rab11fip4), mRNA","Q8BQP8",1088,0,"Rab11 family-interacting protein 4",".",".",".",".","pfam09457","RBD-FIP","FIP domain. The FIP domain is the Rab11-binding domain (RBD) at the C-terminus of a family of Rab11-interacting proteins (FIPs). The Rab proteins constitute the largest family of small GTPases (>60 members in mammals). Among them Rab11 is a well characterized regulator of endocytic and recycling pathways. Rab11 associates with a broad range of post-Golgi organelles, including recycling endosomes.","GO:0003407|neural retina development;GO:0032456|endocytic recycling;GO:0032465|regulation of cytokinesis;GO:1903452|positive regulation of G1 to G0 transition;","GO:0005768|endosome;GO:0005813|centrosome;GO:0030139|endocytic vesicle;GO:0030496|midbody;GO:0032154|cleavage furrow;GO:0048471|perinuclear region of cytoplasm;GO:0055038|recycling endosome membrane;","GO:0005509|calcium ion binding;GO:0031267|small GTPase binding;GO:0042803|protein homodimerization activity;","K12485","RAB11FIP3_4; Rab11 family-interacting protein 3/4"]
["ENSRNOG00000034177",6,0.498159963,28,1.801252269,0.276563129,-1.854319265,0.001018479,0.001004824,"down","yes","Efna5","protein_coding","chr9:102320295-102597413:-","gi|6753724|ref|NP_034239.1|",1011,{"v":1e-124,"d":"1.00E-124"},"ephrin-A5 isoform 2 precursor [Mus musculus]","gi|77020717|gb|AC154385.2|",1894,0,"Mus musculus BAC clone RP23-23O22 from chromosome 17, complete sequence","P97605",378,{"v":6e-120,"d":"6.00E-120"},"Ephrin-A5",".",".",".",".","pfam00812","Ephrin","Ephrin.","GO:0007411|axon guidance;GO:0007413|axonal fasciculation;GO:0007417|central nervous system development;GO:0007420|brain development;GO:0022407|regulation of cell-cell adhesion;GO:0022604|regulation of cell morphogenesis;GO:0031290|retinal ganglion cell axon guidance;GO:0032956|regulation of actin cytoskeleton organization;GO:0043087|regulation of GTPase activity;GO:0048013|ephrin receptor signaling pathway;GO:0048668|collateral sprouting;GO:0048672|positive regulation of collateral sprouting;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050919|negative chemotaxis;GO:0051893|regulation of focal adhesion assembly;GO:0051965|positive regulation of synapse assembly;GO:0061178|regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0070507|regulation of microtubule cytoskeleton organization;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0099560|synaptic membrane adhesion;GO:1900025|negative regulation of substrate adhesion-dependent cell spreading;GO:1904322|cellular response to forskolin;","GO:0005604|basement membrane;GO:0005886|plasma membrane;GO:0005901|caveola;GO:0005912|adherens junction;GO:0031362|anchored component of external side of plasma membrane;GO:0071944|cell periphery;GO:0098982|GABA-ergic synapse;","GO:0005169|neurotrophin TRKB receptor binding;GO:0045499|chemorepellent activity;GO:0046875|ephrin receptor binding;","K05462","EFNA; ephrin-A"]
["ENSRNOG00000015449",4,0.332106642,23,1.479600078,0.224457032,-2.1554888,0.001019003,0.00100503,"down","yes","Tmem171","protein_coding","chr2:30035278-30045049:-","gi|564334945|ref|XP_006231896.1|",1586,0,"PREDICTED: transmembrane protein 171 isoform X3 [Rattus norvegicus]","gi|672041192|ref|XM_006231834.2|",1161,0,"PREDICTED: Rattus norvegicus transmembrane protein 171 (Tmem171), transcript variant X2, mRNA","Q6K0P5",545,0,"Transmembrane protein 171",".",".",".",".","pfam15471","TMEM171","Transmembrane protein family 171. This family of proteins is found in eukaryotes. TMEM171 is also known as parturition-related protein 2. Proteins in this family are typically between 242 and 326 amino acids in length.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000020620",4,0.332106642,23,1.479600078,0.224457032,-2.1554888,0.001019003,0.00100503,"down","yes","Ppp1r32","protein_coding","chr1:207113809-207122358:-","gi|672039677|ref|XP_008758438.1|",2175,0,"PREDICTED: protein phosphatase 1 regulatory subunit 32 isoform X1 [Rattus norvegicus]","gi|21955165|ref|NM_145786.1|",1488,0,"Rattus norvegicus protein phosphatase 1, regulatory subunit 32 (Ppp1r32), mRNA","Q66HR9",842,0,"Protein phosphatase 1 regulatory subunit 32",".",".",".",".","pfam03157","Glutenin_hmw","High molecular weight glutenin subunit. Members of this family include high molecular weight subunits of glutenin. This group of gluten proteins is thought to be largely responsible for the elastic properties of gluten, and hence, doughs. Indeed, glutenin high molecular weight subunits are classified as elastomeric proteins, because the glutenin network can withstand significant deformations without breaking, and return to the original conformation when the stress is removed. Elastomeric proteins differ considerably in amino acid sequence, but they are all polymers whose subunits consist of elastomeric domains, composed of repeated motifs, and non-elastic domains that mediate cross-linking between the subunits. The elastomeric domain motifs are all rich in glycine residues in addition to other hydrophobic residues. High molecular weight glutenin subunits have an extensive central elastomeric domain, flanked by two terminal non-elastic domains that form disulphide cross-links. The central elastomeric domain is characterized by the following three repeated motifs: PGQGQQ, GYYPTS[P/L]QQ, GQQ. It possesses overlapping beta-turns within and between the repeated motifs, and assumes a regular helical secondary structure with a diameter of approx. 1.9 nm and a pitch of approx. 1.5 nm.",".","GO:0036064|ciliary basal body;","GO:0019902|phosphatase binding;","K17571","PPP1R32; protein phosphatase 1 regulatory subunit 32"]
["ENSRNOG00000014761",10,0.830266605,37,2.380226213,0.348818361,-1.519452115,1.03984E-3,0.00102416,"down","yes","Rasd2","protein_coding","chr19:13594291-13605016:+","gi|537193698|gb|ERE77608.1|",1808,0,"GTP-binding protein Rhes-like protein [Cricetulus griseus]","gi|21717662|ref|NM_133568.1|",3445,0,"Rattus norvegicus RASD family, member 2 (Rasd2), mRNA","P63033",561,0,"GTP-binding protein Rhes",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0001963|synaptic transmission, dopaminergic;GO:0007626|locomotory behavior;GO:0031397|negative regulation of protein ubiquitination;GO:0033235|positive regulation of protein sumoylation;GO:0043949|regulation of cAMP-mediated signaling;GO:0051897|positive regulation of protein kinase B signaling;","GO:0005886|plasma membrane;GO:0045202|synapse;","GO:0003924|GTPase activity;GO:0005515|protein binding;GO:0005525|GTP binding;GO:0031624|ubiquitin conjugating enzyme binding;GO:0031681|G-protein beta-subunit binding;GO:0043548|phosphatidylinositol 3-kinase binding;","K07844","RASD2; RASD family, member 2"]
["ENSRNOG00000010450",21,1.743559871,59,3.795495853,0.459376044,-1.12225247,0.001050426,0.001033631,"down","yes","Elovl7","protein_coding","chr2:39789250-39856845:+","gi|300797609|ref|NP_001178773.1|",1511,0,"elongation of very long chain fatty acids protein 7 [Rattus norvegicus]","gi|300797608|ref|NM_001191844.1|",1128,0,"Rattus norvegicus ELOVL fatty acid elongase 7 (Elovl7), mRNA","D4ADY9",586,0,"Elongation of very long chain fatty acids protein 7",".",".",".",".","pfam01151","ELO","GNS1/SUR4 family. Members of this family are involved in long chain fatty acid elongation systems that produce the 26-carbon precursors for ceramide and sphingolipid synthesis. Predicted to be integral membrane proteins, in eukaryotes they are probably located on the endoplasmic reticulum. Yeast ELO3 affects plasma membrane H+-ATPase activity, and may act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1.","GO:0006636|unsaturated fatty acid biosynthetic process;GO:0019367|fatty acid elongation, saturated fatty acid;GO:0030148|sphingolipid biosynthetic process;GO:0034625|fatty acid elongation, monounsaturated fatty acid;GO:0034626|fatty acid elongation, polyunsaturated fatty acid;GO:0035338|long-chain fatty-acyl-CoA biosynthetic process;GO:0042761|very long-chain fatty acid biosynthetic process;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0030176|integral component of endoplasmic reticulum membrane;","GO:0009922|fatty acid elongase activity;GO:0102336|3-oxo-arachidoyl-CoA synthase activity;GO:0102337|3-oxo-cerotoyl-CoA synthase activity;GO:0102338|3-oxo-lignoceronyl-CoA synthase activity;GO:0102756|very-long-chain 3-ketoacyl-CoA synthase activity;","K10250","ELOVL7; elongation of very long chain fatty acids protein 7 [EC:2.3.1.199]"]
["ENSRNOG00000047951",21,1.743559871,59,3.795495853,0.459376044,-1.12225247,0.001050426,0.001033631,"down","yes","Hoxa5","protein_coding","chr4:81302353-81306234:-","gi|564303752|ref|XP_003753945.2|",1614,0,"PREDICTED: homeobox protein Hox-A5 [Rattus norvegicus]","gi|564303751|ref|XM_003753897.2|",2920,0,"PREDICTED: Rattus norvegicus homeobox protein Hox-A5 (LOC103689922), mRNA","A2D5Y4",405,{"v":7e-132,"d":"7.00E-132"},"Homeobox protein Hox-A5",".",".",".",".","pfam00046","Homeobox","Homeobox domain.",".",".",".",".","."]
["ENSRNOG00000006255",1,0.083026661,14,0.900626135,0.09218771,-3.439281766,0.001060546,1.042306E-3,"down","yes","Nipal4","protein_coding","chr10:30583926-30600640:-","gi|157821563|ref|NP_001100465.1|",1859,0,"magnesium transporter NIPA4 [Rattus norvegicus]","gi|157821562|ref|NM_001106995.1|",3143,0,"Rattus norvegicus NIPA-like domain containing 4 (Nipal4), mRNA","Q8BZF2",682,0,"Magnesium transporter NIPA4",".",".",".",".","pfam05653","Mg_trans_NIPA","Magnesium transporter NIPA. NIPA (nonimprinted in Prader-Willi/Angelman syndrome) is a family of integral membrane proteins which function as magnesium transporters.","GO:0015693|magnesium ion transport;GO:1903830|magnesium ion transmembrane transport;","GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0015095|magnesium ion transmembrane transporter activity;","K22733","NIPA, SLC57A2S; magnesium transporter"]
["ENSRNOG00000008939",1,0.083026661,14,0.900626135,0.09218771,-3.439281766,0.001060546,1.042306E-3,"down","yes","Nxph1","protein_coding","chr4:36997669-37311132:+","gi|148681975|gb|EDL13922.1|",1628,0,"neurexophilin 1, isoform CRA_a, partial [Mus musculus]","gi|77404424|ref|NM_012994.2|",2440,0,"Rattus norvegicus neurexophilin 1 (Nxph1), mRNA","Q63366",564,0,"Neurexophilin-1",".",".",".",".","pfam06312","Neurexophilin","Neurexophilin. This family consists of mammalian neurexophilin proteins. Mammalian brains contain four different neurexophilin proteins. Neurexophilins form a family of related glycoproteins that are proteolytically processed after synthesis and bind to alpha-neurexins. The structure and characteristics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins.",".","GO:0005576|extracellular region;","GO:0005102|signaling receptor binding;","K16656","NXPH1; neurexophilin-1"]
["ENSRNOG00000057827",1,0.083026661,14,0.900626135,0.09218771,-3.439281766,0.001060546,1.042306E-3,"down","yes","Lmln2","protein_coding","chr15:28151019-28158129:-","gi|672028480|ref|XP_008766912.1|",3486,0,"PREDICTED: uncharacterized protein RGD1560492 isoform X2 [Rattus norvegicus]","gi|298916630|emb|FQ210346.1|",3032,0,"Rattus norvegicus TL0ABA2YL01 mRNA sequence","Q61YG1",122,{"v":4e-27,"d":"4.00E-27"},"Leishmanolysin-like peptidase",".",".",".",".","pfam01457","Peptidase_M8","Leishmanolysin.","GO:0006508|proteolysis;GO:0007155|cell adhesion;","GO:0016020|membrane;","GO:0004222|metalloendopeptidase activity;GO:0046872|metal ion binding;",".","."]
["ENSRNOG00000052634",26,2.158693174,68,4.374469797,0.493475387,-1.018949967,0.001147591,0.001119935,"down","yes","Lsmem2","protein_coding","chr8:108266345-108279115:-","gi|121583784|ref|NP_001073411.1|",3783,0,"semaphorin-3B precursor [Rattus norvegicus]","gi|672063083|ref|XM_008766551.1|",2747,0,"PREDICTED: Rattus norvegicus sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B (Sema3b), transcript variant X3, mRNA","Q62177",1374,0,"Semaphorin-3B",".",".",".",".","pfam01403","Sema","Sema domain. The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and human plexin A-3.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000012620",17,1.411453229,51,3.280852347,0.430209311,-1.216889345,0.001155708,1.127512E-3,"down","yes","Syngr3","protein_coding","chr10:13704998-13715669:-","gi|831227424|ref|XP_003790837.2|",961,{"v":1e-120,"d":"1.00E-120"},"PREDICTED: synaptogyrin-3 [Otolemur garnettii]","gi|672066853|ref|XM_006245947.2|",1993,0,"PREDICTED: Rattus norvegicus synaptogyrin 3 (Syngr3), transcript variant X1, mRNA","Q8R191",367,{"v":1E-119,"d":"1.00E-119"},"Synaptogyrin-3",".",".",".",".","pfam01284","MARVEL","Membrane-associating domain. MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.","GO:0001504|neurotransmitter uptake;GO:0021762|substantia nigra development;GO:0032411|positive regulation of transporter activity;GO:0045055|regulated exocytosis;","GO:0008021|synaptic vesicle;GO:0016021|integral component of membrane;GO:0030672|synaptic vesicle membrane;GO:0031594|neuromuscular junction;GO:0045202|synapse;","GO:0042169|SH2 domain binding;GO:0047485|protein N-terminus binding;",".","."]
["ENSRNOG00000021833",0,0.04151333,12,0.771965258,0.053776164,-4.216889345,0.001162605,1.132858E-3,"down","yes","Myrfl","protein_coding","chr7:52403650-52519907:-","gi|672021719|ref|XP_008774669.1|",4459,0,"PREDICTED: myelin regulatory factor-like protein isoform X1 [Rattus norvegicus]","gi|672021718|ref|XM_008776447.1|",2679,0,"PREDICTED: Rattus norvegicus myelin regulatory factor-like (Myrfl), transcript variant X1, mRNA","Q3UN70",1568,0,"Myelin regulatory factor-like protein",".",".",".",".","pfam13888","MRF_C2","Myelin gene regulatory factor C-terminal domain 2. This domain is found further downstream of Peptidase_S74, pfam13884, and MRF_C1, pfam13887. The function is not known.","GO:0016540|protein autoprocessing;GO:0045893|positive regulation of transcription, DNA-templated;","GO:0005634|nucleus;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0003700|DNA-binding transcription factor activity;GO:0043565|sequence-specific DNA binding;",".","."]
["ENSRNOG00000031927",0,0.04151333,12,0.771965258,0.053776164,-4.216889345,0.001162605,1.132858E-3,"down","yes","Klk6","protein_coding","chr1:94280340-94286121:+","gi|9506997|ref|NP_062048.1|",1349,0,"kallikrein-6 precursor [Rattus norvegicus]","gi|672036301|ref|XM_006228982.2|",897,0,"PREDICTED: Rattus norvegicus kallikrein related-peptidase 6 (Klk6), transcript variant X1, mRNA","Q92876",361,{"v":7e-124,"d":"7.00E-124"},"Kallikrein-6","mlr3307",117,{"v":3e-29,"d":"3.00E-29"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;GO:0010975|regulation of neuron projection development;GO:0045745|positive regulation of G protein-coupled receptor signaling pathway;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005737|cytoplasm;GO:0030141|secretory granule;","GO:0004252|serine-type endopeptidase activity;GO:0008233|peptidase activity;","K08667","KLK6, PRSS9; kallikrein 6 [EC:3.4.21.-]"]
["ENSRNOG00000032740",0,0.04151333,12,0.771965258,0.053776164,-4.216889345,0.001162605,1.132858E-3,"down","yes","Tmem258b","protein_coding","chr9:56450406-56450645:+","gi|52346184|ref|NP_001005138.1|",311,{"v":3e-35,"d":"3.00E-35"},"transmembrane protein 258 [Xenopus tropicalis]","gi|672024011|ref|XM_002727225.4|",240,{"v":2E-121,"d":"2.00E-121"},"PREDICTED: Rattus norvegicus transmembrane protein 258 B (Tmem258b), mRNA","Q6DDB3",124,{"v":1e-36,"d":"1.00E-36"},"Transmembrane protein 258",".",".",".",".","pfam05251","UPF0197","Uncharacterized protein family (UPF0197). This family of proteins is functionally uncharacterized.","GO:0006487|protein N-linked glycosylation;","GO:0016021|integral component of membrane;GO:0032991|protein-containing complex;GO:0034998|oligosaccharyltransferase I complex;GO:0043227|membrane-bounded organelle;",".",".","."]
["ENSRNOG00000064644",0,0.04151333,12,0.771965258,0.053776164,-4.216889345,0.001162605,1.132858E-3,"down","yes","ENSRNOG00000064644","protein_coding","chr2:102238973-102239962:+","gi|820974507|ref|XP_012360476.1|",168,{"v":6e-13,"d":"6.00E-13"},"PREDICTED: CCR4-NOT transcription complex subunit 8 isoform X2 [Nomascus leucogenys]",".",".",".",".","Q9UFF9",65.9,{"v":2e-13,"d":"2.00E-13"},"CCR4-NOT transcription complex subunit 8",".",".",".",".","pfam04857","CAF1","CAF1 family ribonuclease. The major pathways of mRNA turnover in eukaryotes initiate with shortening of the polyA tail. CAF1 encodes a critical component of the major cytoplasmic deadenylase in yeast. Both Caf1p is required for normal mRNA deadenylation in vivo and localizes to the cytoplasm. Caf1p copurifies with a Ccr4p-dependent polyA-specific exonuclease activity. Some members of this family include and inserted RNA binding domain pfam01424. This family of proteins is related to other exonucleases pfam00929 (Bateman A pers. obs.). The crystal structure of Saccharomyces cerevisiae Pop2 has been resolved at 2.3 Angstrom#resolution.",".",".",".",".","."]
["ENSRNOG00000066561",0,0.04151333,12,0.771965258,0.053776164,-4.216889345,0.001162605,1.132858E-3,"down","yes","ENSRNOG00000066561","protein_coding","chr9:2780475-2782261:-","gi|564365534|ref|XP_006243865.1|",1088,{"v":1e-145,"d":"1.00E-145"},"PREDICTED: poly(rC)-binding protein 4 isoform X2 [Rattus norvegicus]","gi|672063078|ref|XM_006243803.2|",397,0,"PREDICTED: Rattus norvegicus poly(rC) binding protein 4 (Pcbp4), transcript variant X2, mRNA","P57724",387,{"v":7e-132,"d":"7.00E-132"},"Poly(rC)-binding protein 4",".",".",".",".","pfam00013","KH_1","KH domain. KH motifs bind RNA in vitro. Autoantibodies to Nova, a KH domain protein, cause paraneoplastic opsoclonus ataxia.",".",".",".",".","."]
["ENSRNOG00000002771",3,0.249079982,20,1.286608764,0.19359419,-2.368892438,0.001176324,0.001145005,"down","yes","Ereg","protein_coding","chr14:17027287-17041062:-","gi|11078689|ref|NP_067721.1|",781,{"v":7e-102,"d":"7.00E-102"},"proepiregulin preproprotein [Rattus norvegicus]","gi|11078688|ref|NM_021689.1|",828,0,"Rattus norvegicus epiregulin (Ereg), mRNA","Q9Z0L5",305,{"v":2e-103,"d":"2.00E-103"},"Proepiregulin",".",".",".",".","pfam00008","EGF","EGF-like domain. There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.","GO:0001525|angiogenesis;GO:0001550|ovarian cumulus expansion;GO:0001556|oocyte maturation;GO:0001819|positive regulation of cytokine production;GO:0007143|female meiotic nuclear division;GO:0007173|epidermal growth factor receptor signaling pathway;GO:0007267|cell-cell signaling;GO:0008283|cell proliferation;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0009299|mRNA transcription;GO:0019221|cytokine-mediated signaling pathway;GO:0030728|ovulation;GO:0032755|positive regulation of interleukin-6 production;GO:0042327|positive regulation of phosphorylation;GO:0042700|luteinizing hormone signaling pathway;GO:0043434|response to peptide hormone;GO:0043616|keratinocyte proliferation;GO:0045089|positive regulation of innate immune response;GO:0045740|positive regulation of DNA replication;GO:0045741|positive regulation of epidermal growth factor-activated receptor activity;GO:0045766|positive regulation of angiogenesis;GO:0045840|positive regulation of mitotic nuclear division;GO:0045860|positive regulation of protein kinase activity;GO:0045892|negative regulation of transcription, DNA-templated;GO:0048146|positive regulation of fibroblast proliferation;GO:0048160|primary follicle stage;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0051151|negative regulation of smooth muscle cell differentiation;GO:0051781|positive regulation of cell division;","GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0005154|epidermal growth factor receptor binding;GO:0008083|growth factor activity;","K09784","EREG; epiregulin"]
["ENSRNOG00000060290",7,0.581186624,30,1.929913146,0.301146518,-1.731462517,1.179881E-3,1.147721E-3,"down","yes","Snord87","snoRNA","chr5:9297489-9297573:+",".",".",".",".","gi|18139791|gb|AF396685.1|",85,{"v":9e-36,"d":"9.00E-36"},"Rattus norvegicus C/D box U87 snoRNA gene, complete sequence",".",".",".",".",".",".",".",".","pfam09642","YonK","YonK protein. YonK protein is expressed by the bacterial prophage SPbetaC. It is a 63 residue protein that associates into a homo-octamer in the form of a beta-stranded barrel with four outer helical features at points of the compass. Its function is unknown.",".",".",".",".","."]
["ENSRNOG00000025238",2,0.166053321,17,1.093617449,0.15183858,-2.719389685,1.231116E-3,0.001194338,"down","yes","Bpifb5","protein_coding","chr3:142709530-142728344:+","gi|293346412|ref|XP_002726319.1|",2205,0,"PREDICTED: uncharacterized protein Bpifb5 [Rattus norvegicus]","gi|672017603|ref|XM_002726273.3|",1611,0,"PREDICTED: Rattus norvegicus BPI fold containing family B, member 5 (Bpifb5), mRNA",".",".",".",".",".",".",".",".","pfam01273","LBP_BPI_CETP","LBP / BPI / CETP family, N-terminal domain. The N and C terminal domains of the LBP/BPI/CETP family are structurally similar.",".",".","GO:0008289|lipid binding;",".","."]
["ENSRNOG00000021796",5,0.415133303,25,1.608260955,0.258125587,-1.953854939,1.304059E-3,0.001256523,"down","yes","RGD1565166","protein_coding","chr10:10361948-10371046:+","gi|157786582|ref|NP_001099232.1|",1865,0,"UPF0764 protein C16orf89 homolog precursor [Rattus norvegicus]","gi|157786581|ref|NM_001105762.1|",1529,0,"Rattus norvegicus similar to MGC45438 protein (RGD1565166), mRNA","Q3UST5",647,0,"UPF0764 protein C16orf89 homolog",".",".",".",".",".",".",".",".","GO:0005829|cytosol;GO:0016020|membrane;","GO:0042803|protein homodimerization activity;",".","."]
["ENSRNOG00000054420",8,0.664213284,32,2.058574022,0.322656983,-1.631926844,1.316181E-3,0.00126744,"down","yes","Vdr","protein_coding","chr7:128987981-129037677:-","gi|149032183|gb|EDL87095.1|",2066,0,"vitamin D receptor [Rattus norvegicus]","gi|8394528|ref|NM_017058.1|",2021,0,"Rattus norvegicus vitamin D (1,25- dihydroxyvitamin D3) receptor (Vdr), mRNA","P13053",798,0,"Vitamin D3 receptor",".",".",".",".","pfam00105","zf-C4","Zinc finger, C4 type (two domains). In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0000902|cell morphogenesis;GO:0001501|skeletal system development;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006816|calcium ion transport;GO:0006874|cellular calcium ion homeostasis;GO:0007275|multicellular organism development;GO:0007507|heart development;GO:0007568|aging;GO:0007595|lactation;GO:0008285|negative regulation of cell proliferation;GO:0009887|animal organ morphogenesis;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010839|negative regulation of keratinocyte proliferation;GO:0010980|positive regulation of vitamin D 24-hydroxylase activity;GO:0030154|cell differentiation;GO:0030279|negative regulation of ossification;GO:0032355|response to estradiol;GO:0038183|bile acid signaling pathway;GO:0045618|positive regulation of keratinocyte differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046697|decidualization;GO:0050892|intestinal absorption;GO:0051592|response to calcium ion;GO:0051924|regulation of calcium ion transport;GO:0060058|positive regulation of apoptotic process involved in mammary gland involution;GO:0060558|regulation of calcidiol 1-monooxygenase activity;GO:0060745|mammary gland branching involved in pregnancy;GO:0070561|vitamin D receptor signaling pathway;GO:0071305|cellular response to vitamin D;GO:0097190|apoptotic signaling pathway;GO:1900155|negative regulation of bone trabecula formation;GO:1904646|cellular response to amyloid-beta;GO:2000830|positive regulation of parathyroid hormone secretion;","GO:0000791|euchromatin;GO:0000792|heterochromatin;GO:0001651|dense fibrillar component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0005901|caveola;GO:0016363|nuclear matrix;GO:0030315|T-tubule;GO:0043231|intracellular membrane-bounded organelle;GO:0043235|receptor complex;GO:0048471|perinuclear region of cytoplasm;GO:0090575|RNA polymerase II transcription factor complex;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0004879|nuclear receptor activity;GO:0005499|vitamin D binding;GO:0005515|protein binding;GO:0008270|zinc ion binding;GO:0038186|lithocholic acid receptor activity;GO:0043565|sequence-specific DNA binding;GO:0046965|retinoid X receptor binding;GO:0070644|vitamin D response element binding;GO:1902098|calcitriol binding;GO:1902121|lithocholic acid binding;","K08539","VDR, NR1I1; vitamin D3 receptor"]
["ENSRNOG00000065976",22,1.826586532,60,3.859826291,0.473230242,-1.079385821,0.001365751,1.310634E-3,"down","yes","ENSRNOG00000065976","snoRNA","chr7:111625088-111625142:-",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","pfam14048","MBD_C","C-terminal domain of methyl-CpG binding protein 2 and 3. CpG-methylation is a frequently occurring epigenetic modification of vertebrate genomes resulting in transcriptional repression. This domain was found at the C-terminus of the methyl-CpG-binding domain (MBD) containing proteins MBD2 and MBD3, the latter was shown to not bind directly to methyl-CpG DNA but rather interact with components of the NuRD/Mi2 complex, an abundant deacetylase complex. The domain is subject to structure determination by the Joint Center of Structural Genomics.",".",".",".",".","."]
["ENSRNOG00000039504",21,1.743559871,58,3.731165415,0.467296321,-1.097590416,0.001417872,0.001356174,"down","yes","ENSRNOG00000039504","protein_coding","chr14:17478443-17525047:-","gi|392332999|ref|XP_003752762.1|",3296,0,"PREDICTED: alpha-fetoprotein isoform X1 [Rattus norvegicus]","gi|672027743|ref|XM_003752714.3|",2349,0,"PREDICTED: Rattus norvegicus similar to alpha-fetoprotein (LOC360919), transcript variant X1, mRNA","Q8MJU5",458,{"v":9e-150,"d":"9.00E-150"},"Alpha-fetoprotein",".",".",".",".","pfam00273","Serum_albumin","Serum albumin family.","GO:0006810|transport;","GO:0005615|extracellular space;GO:0005737|cytoplasm;","GO:0005504|fatty acid binding;GO:0008270|zinc ion binding;",".","."]
["ENSRNOG00000006110",10,0.830266605,36,2.315895775,0.358507759,-1.47992375,1.511854E-3,0.00143982,"down","yes","Jph1","protein_coding","chr5:2030281-2125284:+","gi|148682412|gb|EDL14359.1|",2958,0,"junctophilin 1, partial [Mus musculus]","gi|157820160|ref|NM_001106630.1|",2461,0,"Rattus norvegicus junctophilin 1 (Jph1), mRNA","Q9ET80",1094,0,"Junctophilin-1",".",".",".",".","pfam02493","MORN","MORN repeat. The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22).  #=GF CC   A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesised to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.","GO:0007517|muscle organ development;","GO:0005654|nucleoplasm;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0014701|junctional sarcoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0016529|sarcoplasmic reticulum;GO:0030018|Z disc;GO:0030314|junctional membrane complex;","GO:0008307|structural constituent of muscle;","K19530","JPH; junctophilin"]
["ENSRNOG00000007542",10,0.830266605,36,2.315895775,0.358507759,-1.47992375,1.511854E-3,0.00143982,"down","yes","Scg5","protein_coding","chr3:100544099-100588463:-","gi|149022924|gb|EDL79818.1|",1030,{"v":2E-137,"d":"2.00E-137"},"secretory granule neuroendocrine protein 1 [Rattus norvegicus]","gi|298912302|emb|FQ213100.1|",1133,0,"Rattus norvegicus TL0AAA49YL10 mRNA sequence","P27682",399,{"v":3e-138,"d":"3.00E-138"},"Neuroendocrine protein 7B2",".",".",".",".","pfam05281","Secretogranin_V","Neuroendocrine protein 7B2 precursor (Secretogranin V). The neuroendocrine protein 7B2 has a critical role in the proteolytic conversion and activation of proPC2, the enzyme responsible for the proteolytic conversion of many peptide hormone precursors. The 7B2 protein acts as an intracellular binding protein for proPC2, facilitates its maturation, and is required for its enzymatic activity. Processing of many important peptide precursors does not occur in 7B2 nulls. 7B2 null mice exhibit a unique form of Cushing's disease with many atypical symptoms, such as hypoglycemia.","GO:0006886|intracellular protein transport;GO:0007218|neuropeptide signaling pathway;GO:0016486|peptide hormone processing;GO:0043086|negative regulation of catalytic activity;GO:0046883|regulation of hormone secretion;","GO:0005576|extracellular region;GO:0005634|nucleus;GO:0030141|secretory granule;","GO:0004857|enzyme inhibitor activity;GO:0005515|protein binding;GO:0030234|enzyme regulator activity;GO:0051082|unfolded protein binding;",".","."]
["ENSRNOG00000011011",10,0.830266605,36,2.315895775,0.358507759,-1.47992375,1.511854E-3,0.00143982,"down","yes","Nmb","protein_coding","chr1:134869446-134872190:-","gi|157820747|ref|NP_001102619.1|",495,{"v":3e-60,"d":"3.00E-60"},"neuromedin-B precursor [Rattus norvegicus]","gi|157820746|ref|NM_001109149.1|",660,0,"Rattus norvegicus neuromedin B (Nmb), mRNA","Q9CR53",176,{"v":2e-54,"d":"2.00E-54"},"Neuromedin-B",".",".",".",".","pfam05109","Herpes_BLLF1","Herpes virus major outer envelope glycoprotein (BLLF1). This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralizing antibodies in vivo.","GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007218|neuropeptide signaling pathway;GO:0008284|positive regulation of cell proliferation;GO:0042593|glucose homeostasis;GO:0046887|positive regulation of hormone secretion;GO:0046888|negative regulation of hormone secretion;GO:0050482|arachidonic acid secretion;","GO:0005576|extracellular region;GO:0043005|neuron projection;","GO:0005184|neuropeptide hormone activity;GO:0031710|neuromedin B receptor binding;","K05223","NMB; neuromedin B"]
["ENSRNOG00000024657",10,0.830266605,36,2.315895775,0.358507759,-1.47992375,1.511854E-3,0.00143982,"down","yes","Mfsd4a","protein_coding","chr13:43469488-43510467:-","gi|564380547|ref|XP_006249853.1|",2589,0,"PREDICTED: major facilitator superfamily domain-containing protein 4 isoform X1 [Rattus norvegicus]","gi|672073824|ref|XM_006249791.2|",3742,0,"PREDICTED: Rattus norvegicus major facilitator superfamily domain containing 4 (Mfsd4), transcript variant X1, mRNA","Q6PDC8",961,0,"Major facilitator superfamily domain-containing protein 4A",".",".",".",".","pfam07690","MFS_1","Major Facilitator Superfamily.","GO:1904659|glucose transmembrane transport;","GO:0016021|integral component of membrane;","GO:0005355|glucose transmembrane transporter activity;",".","."]
["ENSRNOG00000012521",19,1.57750655,54,3.473843662,0.454109829,-1.138886833,1.513655E-3,0.001441106,"down","yes","Shisa2","protein_coding","chr15:33805958-33811013:+","gi|300794277|ref|NP_001178865.1|",1255,{"v":3e-167,"d":"3.00E-167"},"protein shisa-2 homolog precursor [Rattus norvegicus]","gi|256355184|ref|NM_145463.5|",1328,0,"Mus musculus shisa family member 2 (Shisa2), mRNA","Q8QZV2",484,{"v":4E-167,"d":"4.00E-167"},"Protein shisa-2 homolog",".",".",".",".","pfam13908","Shisa","Wnt and FGF inhibitory regulator. Shisa is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface.","GO:0030178|negative regulation of Wnt signaling pathway;GO:0040037|negative regulation of fibroblast growth factor receptor signaling pathway;","GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000065744",6,0.498159963,27,1.736921831,0.286806208,-1.801851845,1.558739E-3,0.001478087,"down","yes","ENSRNOG00000065744","lncRNA","chr3:1379622-1382303:+","gi|149021375|gb|EDL78838.1|",585,{"v":4e-67,"d":"4.00E-67"},"rCG59047, partial [Rattus norvegicus]","gi|86439999|gb|AC112083.7|",417,0,"Rattus norvegicus BAC CH230-288C21 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P11369",195,{"v":6e-53,"d":"6.00E-53"},"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam00607","Gag_p24","gag gene protein p24 (core nucleocapsid protein). p24 forms inner protein layer of the nucleocapsid. ELISA tests for p24 is the most commonly used method to demonstrate virus replication both in vivo and in vitro.",".",".",".",".","."]
["ENSRNOG00000001971",17,1.411453229,50,3.216521909,0.438813498,-1.188320192,0.001590577,0.001505152,"down","yes","Bbx","protein_coding","chr11:50381247-50623251:+","gi|672070864|ref|XP_008766856.1|",4571,0,"PREDICTED: HMG box transcription factor BBX isoform X2 [Rattus norvegicus]","gi|672070869|ref|XM_008768637.1|",2858,0,"PREDICTED: Rattus norvegicus bobby sox homolog (Drosophila) (Bbx), transcript variant X4, mRNA","Q8VBW5",1561,0,"HMG box transcription factor BBX",".",".",".",".","pfam09667","DUF2028","Domain of unknown function (DUF2028). This region of similarity is found in the vertebrate homologues of the drosophila Bobby Sox.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0008150|biological_process;GO:0060348|bone development;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:1990837|sequence-specific double-stranded DNA binding;","K21643","BBX, HBP2; HMG box transcription factor BBX"]
["ENSRNOG00000024506",17,1.411453229,50,3.216521909,0.438813498,-1.188320192,0.001590577,0.001505152,"down","yes","ENSRNOG00000024506","protein_coding","chr5:75971381-76002176:+","gi|66730490|ref|NP_001019517.1|",2052,0,"uncharacterized protein C9orf43 homolog [Rattus norvegicus]","gi|66730489|ref|NM_001024346.1|",1650,0,"Rattus norvegicus similar to hypothetical protein 4933430I17 (LOC500475), mRNA",".",".",".",".",".",".",".",".","pfam15504","DUF4647","Domain of unknown function (DUF4647). This family of proteins is found in eukaryotes. Proteins in this family are typically between 282 and 480 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000000041",12,0.996319926,40,2.573217527,0.38718838,-1.368892438,1.614873E-3,0.001526788,"down","yes","Slc26a1","protein_coding","chr14:1040243-1045849:+","gi|148540082|ref|NP_071623.2|",3584,0,"sulfate anion transporter 1 [Rattus norvegicus]","gi|148540081|ref|NM_022287.2|",3374,0,"Rattus norvegicus solute carrier family 26 (anion exchanger), member 1 (Slc26a1), mRNA","P45380",1377,0,"Sulfate anion transporter 1","Cgl1025",163,{"v":5e-41,"d":"5.00E-41"},"COG0659","pfam00916","Sulfate_transp","Sulfate transporter family. Mutations in human SLC26A2 lead to several human diseases.","GO:0006821|chloride transport;GO:0008272|sulfate transport;GO:0015701|bicarbonate transport;GO:0019532|oxalate transport;GO:1902358|sulfate transmembrane transport;GO:1902476|chloride transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0016323|basolateral plasma membrane;","GO:0008271|secondary active sulfate transmembrane transporter activity;GO:0015106|bicarbonate transmembrane transporter activity;GO:0015108|chloride transmembrane transporter activity;GO:0015116|sulfate transmembrane transporter activity;GO:0015301|anion:anion antiporter activity;GO:0019531|oxalate transmembrane transporter activity;","K14700","SLC26A1, SAT1; solute carrier family 26 (sulfate anion transporter), member 1"]
["ENSRNOG00000017982",12,0.996319926,40,2.573217527,0.38718838,-1.368892438,1.614873E-3,0.001526788,"down","yes","Pnliprp2","protein_coding","chr1:257897766-257916434:+","gi|17105374|ref|NP_476554.1|",2597,0,"pancreatic lipase-related protein 2 precursor [Rattus norvegicus]","gi|17105373|ref|NM_057206.1|",1536,0,"Rattus norvegicus pancreatic lipase related protein 2 (Pnliprp2), mRNA","P54318",976,0,"Pancreatic lipase-related protein 2",".",".",".",".","pfam00151","Lipase","Lipase.","GO:0006644|phospholipid metabolic process;GO:0006968|cellular defense response;GO:0009395|phospholipid catabolic process;GO:0009617|response to bacterium;GO:0009791|post-embryonic development;GO:0016042|lipid catabolic process;GO:0019376|galactolipid catabolic process;GO:0019433|triglyceride catabolic process;GO:0032094|response to food;GO:0033993|response to lipid;GO:0034638|phosphatidylcholine catabolic process;GO:0043434|response to peptide hormone;GO:0044258|intestinal lipid catabolic process;GO:0051384|response to glucocorticoid;","GO:0005615|extracellular space;GO:0042589|zymogen granule membrane;GO:0043005|neuron projection;","GO:0004620|phospholipase activity;GO:0004806|triglyceride lipase activity;GO:0005509|calcium ion binding;GO:0016298|lipase activity;GO:0047372|acylglycerol lipase activity;GO:0047714|galactolipase activity;GO:0102549|1-18:1-2-16:0-monogalactosyldiacylglycerol lipase activity;","K14075","PNLIPRP2, PLRP2; pancreatic lipase-related protein 2 [EC:3.1.1.3]"]
["ENSRNOG00000026056",12,0.996319926,40,2.573217527,0.38718838,-1.368892438,1.614873E-3,0.001526788,"down","yes","Ccnb1ip1","protein_coding","chr15:24014908-24028475:-","gi|564386005|ref|XP_006251963.1|",1583,0,"PREDICTED: E3 ubiquitin-protein ligase CCNB1IP1 isoform X3 [Rattus norvegicus]","gi|672077652|ref|XM_008770567.1|",1784,0,"PREDICTED: Rattus norvegicus cyclin B1 interacting protein 1, E3 ubiquitin protein ligase (Ccnb1ip1), transcript variant X5, mRNA","D3Z3K2",555,0,"E3 ubiquitin-protein ligase CCNB1IP1",".",".",".",".","pfam14634","zf-RING_5","zinc-RING finger domain.","GO:0001825|blastocyst formation;GO:0007131|reciprocal meiotic recombination;GO:0007286|spermatid development;GO:0016567|protein ubiquitination;GO:0051026|chiasma assembly;","GO:0000794|condensed nuclear chromosome;GO:0000795|synaptonemal complex;","GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;","K10639","CCNB1IP1, HEI10; E3 ubiquitin-protein ligase CCNP1IP1 [EC:2.3.2.27]"]
["ENSRNOG00000004229",13,1.079346587,42,2.701878404,0.399480075,-1.323804548,0.001637399,1.546941E-3,"down","yes","Tac3","protein_coding","chr7:63562552-63569170:+","gi|9507175|ref|NP_062035.1|",457,{"v":3e-54,"d":"3.00E-54"},"tachykinin-3 precursor [Rattus norvegicus]","gi|451958175|ref|NM_019162.2|",717,0,"Rattus norvegicus tachykinin 3 (Tac3), mRNA","P08435",180,{"v":1e-55,"d":"1.00E-55"},"Tachykinin-3",".",".",".",".","pfam03823","Neurokinin_B","Neurokinin B.","GO:0007217|tachykinin receptor signaling pathway;GO:0007218|neuropeptide signaling pathway;GO:0043278|response to morphine;GO:0045777|positive regulation of blood pressure;GO:1902093|positive regulation of flagellated sperm motility;","GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0031836|neuromedin K receptor binding;GO:0031837|substance K receptor binding;","K05240","TAC3; tachykinin 3"]
["ENSRNOG00000014771",7,0.581186624,29,1.865582707,0.311530881,-1.682552917,1.775207E-3,0.001666303,"down","yes","Wfdc8","protein_coding","chr3:153324413-153339842:-","gi|672017717|ref|XP_006224802.2|",1396,0,"PREDICTED: WAP four-disulfide core domain protein 8 [Rattus norvegicus]","gi|672017716|ref|XM_006224740.2|",1052,0,"PREDICTED: Rattus norvegicus WAP four-disulfide core domain 8 (Wfdc8), mRNA","Q4KUS1",412,{"v":1e-138,"d":"1.00E-138"},"WAP four-disulfide core domain protein 8",".",".",".",".","pfam00014","Kunitz_BPTI","Kunitz/Bovine pancreatic trypsin inhibitor domain. Indicative of a protease inhibitor, usually a serine protease inhibitor. Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure. Certain family members are similar to the tick anticoagulant peptide (TAP). This is a highly selective inhibitor of factor Xa in the blood coagulation pathways. TAP molecules are highly dipolar, and are arranged to form a twisted two- stranded antiparallel beta-sheet followed by an alpha helix.","GO:0010951|negative regulation of endopeptidase activity;","GO:0005576|extracellular region;","GO:0004867|serine-type endopeptidase inhibitor activity;","K23623","WFDC8; WAP four-disulfide core domain protein 8"]
["ENSRNOG00000018790",1,0.083026661,13,0.836295696,0.099279072,-3.332366562,1.84603E-3,1.726904E-3,"down","yes","Kcnh4","protein_coding","chr10:85668337-85688158:-","gi|149054246|gb|EDM06063.1|",4683,0,"potassium voltage-gated channel, subfamily H (eag-related), member 4 [Rattus norvegicus]","gi|16758435|ref|NM_053630.1|",3712,0,"Rattus norvegicus potassium voltage-gated channel subfamily H member 4 (Kcnh4), mRNA","Q9R1T9",1808,0,"Potassium voltage-gated channel subfamily H member 4","CC0285_1",92.8,{"v":2E-19,"d":"2.00E-19"},"COG2202","pfam13426","PAS_9","PAS domain.","GO:0034765|regulation of ion transmembrane transport;GO:0042391|regulation of membrane potential;GO:0071805|potassium ion transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;","GO:0005249|voltage-gated potassium channel activity;","K04907","KCNH4, KV12.3; potassium voltage-gated channel Eag-related subfamily H member 4"]
["ENSRNOG00000039476",1,0.083026661,13,0.836295696,0.099279072,-3.332366562,1.84603E-3,1.726904E-3,"down","yes","Pcdhb2","protein_coding","chr18:29005996-29008782:+","gi|157819959|ref|NP_001102593.1|",3896,0,"protocadherin beta-2 [Rattus norvegicus]","gi|86440007|gb|AC096374.7|",2787,0,"Rattus norvegicus BAC CH230-17K7 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q5DRD2",1154,0,"Protocadherin beta-2",".",".",".",".","pfam08266","Cadherin_2","Cadherin-like. This cadherin domain is usually the most N-terminal copy of the domain.","GO:0007155|cell adhesion;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;","GO:0005887|integral component of plasma membrane;","GO:0005509|calcium ion binding;","K16494","PCDHB; protocadherin beta"]
["ENSRNOG00000048230",1,0.083026661,13,0.836295696,0.099279072,-3.332366562,1.84603E-3,1.726904E-3,"down","yes","ENSRNOG00000048230","protein_coding","chr7:15821379-15838813:+","gi|392349284|ref|XP_234980.5|",2159,0,"PREDICTED: sperm motility kinase W-like [Rattus norvegicus]","gi|672058325|ref|XR_593312.1|",1678,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102557062 (LOC102557062), transcript variant X7, ncRNA","Q8C0V7",577,0,"Putative sperm motility kinase W",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006468|protein phosphorylation;GO:0035556|intracellular signal transduction;GO:0043066|negative regulation of apoptotic process;","GO:0005737|cytoplasm;","GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;",".","."]
["ENSRNOG00000013610",8,0.664213284,31,1.994243584,0.333065273,-1.586123154,0.001951076,0.001817774,"down","yes","Chrna5","protein_coding","chr8:55369794-55398146:+","gi|158534079|ref|NP_058774.2|",2205,0,"neuronal acetylcholine receptor subunit alpha-5 precursor [Rattus norvegicus]","gi|158534078|ref|NM_017078.2|",3007,0,"Rattus norvegicus cholinergic receptor nicotinic alpha 5 subunit (Chrna5), mRNA","P20420",852,0,"Neuronal acetylcholine receptor subunit alpha-5",".",".",".",".","pfam02931","Neur_chan_LBD","Neurotransmitter-gated ion-channel ligand binding domain. This family is the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.","GO:0007165|signal transduction;GO:0007268|chemical synaptic transmission;GO:0007271|synaptic transmission, cholinergic;GO:0034220|ion transmembrane transport;GO:0035094|response to nicotine;GO:0035095|behavioral response to nicotine;GO:0042391|regulation of membrane potential;GO:0050877|nervous system process;GO:0060079|excitatory postsynaptic potential;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005892|acetylcholine-gated channel complex;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0098691|dopaminergic synapse;","GO:0004888|transmembrane signaling receptor activity;GO:0005230|extracellular ligand-gated ion channel activity;GO:0005515|protein binding;GO:0015464|acetylcholine receptor activity;GO:0022848|acetylcholine-gated cation-selective channel activity;GO:0030594|neurotransmitter receptor activity;GO:0042166|acetylcholine binding;GO:0044877|protein-containing complex binding;","K04807","CHRNA5; nicotinic acetylcholine receptor alpha-5"]
["ENSRNOG00000061622",8,0.664213284,31,1.994243584,0.333065273,-1.586123154,0.001951076,0.001817774,"down","yes","Gm26083","scaRNA","chr10:102276365-102276548:+",".",".",".",".","gi|644990399|tpe|HG981309.1|",122,{"v":7e-56,"d":"7.00E-56"},"TPA: Mus musculus long non-coding RNA OTTMUST00000116901.1 (RP23-41E14.4 gene), lincRNA",".",".",".",".",".",".",".",".","pfam09937","DUF2169","Uncharacterized protein conserved in bacteria (DUF2169). This domain, found in various hypothetical prokaryotic proteins, has no known function.",".",".",".",".","."]
["ENSRNOG00000050207",20,1.66053321,55,3.5381741,0.469319249,-1.091358462,1.981029E-3,1.843531E-3,"down","yes","Utf1","protein_coding","chr1:194740339-194741465:+","gi|149061439|gb|EDM11862.1|",1400,0,"rCG47962 [Rattus norvegicus]","gi|196259784|ref|NM_001131032.1|",1011,0,"Rattus norvegicus undifferentiated embryonic cell transcription factor 1 (Utf1), mRNA","Q6J1H4",506,{"v":1e-178,"d":"1.00E-178"},"Undifferentiated embryonic cell transcription factor 1",".",".",".",".","pfam13837","Myb_DNA-bind_4","Myb/SANT-like DNA-binding domain. This presumed domain appears to be related to other Myb/SANT-like DNA binding domains. In particular pfam10545 seems most related. This family is greatly expanded in plants and appears in several proteins annotated as transposon proteins.","GO:0008584|male gonad development;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0003713|transcription coactivator activity;GO:0017025|TBP-class protein binding;GO:0071837|HMG box domain binding;",".","."]
["ENSRNOG00000063053",5,0.415133303,24,1.543930516,0.26888082,-1.89496125,0.002025182,0.001881608,"down","yes","ENSRNOG00000063053","protein_coding","chr5:19001071-19001525:+","gi|157818349|ref|NP_001100012.1|",377,{"v":1e-43,"d":"1.00E-43"},"ubiquitin-conjugating enzyme E2 C [Rattus norvegicus]","gi|298911650|emb|FQ222472.1|",242,{"v":2e-122,"d":"2.00E-122"},"Rattus norvegicus TL0ADA23YA06 mRNA sequence","Q4R9D1",145,{"v":1e-43,"d":"1.00E-43"},"Ubiquitin-conjugating enzyme E2 C",".",".",".",".","pfam00179","UQ_con","Ubiquitin-conjugating enzyme. Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. TSG101 is one of several UBC homologues that lacks this active site cysteine.",".",".",".",".","."]
["ENSRNOG00000009646",0,0.04151333,11,0.70763482,0.058664906,-4.091358462,0.002046457,0.001899718,"down","yes","Nyx","protein_coding","chrX:9280864-9301900:-","gi|155369289|ref|NP_001094437.1|",1924,0,"nyctalopin precursor [Rattus norvegicus]","gi|155369288|ref|NM_001100967.1|",1962,0,"Rattus norvegicus nyctalopin (Nyx), mRNA","P83503",701,0,"Nyctalopin",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.","GO:0007601|visual perception;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0031012|extracellular matrix;","GO:0003674|molecular_function;","K08129","NYX; nyctalopin"]
["ENSRNOG00000021434",0,0.04151333,11,0.70763482,0.058664906,-4.091358462,0.002046457,0.001899718,"down","yes","Usp51","protein_coding","chrX:18376930-18379888:-","gi|157818203|ref|NP_001101722.1|",2759,0,"ubiquitin carboxyl-terminal hydrolase 51 [Rattus norvegicus]","gi|672087031|ref|XM_006256768.2|",2221,0,"PREDICTED: Rattus norvegicus ubiquitin specific peptidase 51 (Usp51), transcript variant X2, mRNA","B1AY15",952,0,"Ubiquitin carboxyl-terminal hydrolase 51",".",".",".",".","pfam00443","UCH","Ubiquitin carboxyl-terminal hydrolase.","GO:0006511|ubiquitin-dependent protein catabolic process;GO:0010564|regulation of cell cycle process;GO:0010569|regulation of double-strand break repair via homologous recombination;GO:0016578|histone deubiquitination;GO:0016579|protein deubiquitination;GO:2001020|regulation of response to DNA damage stimulus;GO:2001032|regulation of double-strand break repair via nonhomologous end joining;",".","GO:0003682|chromatin binding;GO:0004843|thiol-dependent ubiquitin-specific protease activity;GO:0008270|zinc ion binding;GO:0042393|histone binding;","K11366","USP22_27_51, UBP8; ubiquitin carboxyl-terminal hydrolase 22/27/51 [EC:3.4.19.12]"]
["ENSRNOG00000057750",0,0.04151333,11,0.70763482,0.058664906,-4.091358462,0.002046457,0.001899718,"down","yes","AABR07018058.1","protein_coding","chr15:31592001-31592384:-","gi|731501926|ref|XP_003417074.2|",638,{"v":6e-83,"d":"6.00E-83"},"PREDICTED: nuclear transport factor 2 isoform X1 [Loxodonta africana]","gi|672084785|ref|XM_006255480.2|",336,{"v":2E-174,"d":"2.00E-174"},"PREDICTED: Rattus norvegicus nuclear transport factor 2 (Nutf2), transcript variant X1, mRNA","P61972",249,{"v":3e-84,"d":"3.00E-84"},"Nuclear transport factor 2",".",".",".",".","pfam02136","NTF2","Nuclear transport factor 2 (NTF2) domain. This family includes the NTF2-like Delta-5-3-ketosteroid isomerase proteins.",".",".",".",".","."]
["ENSRNOG00000000926",2,0.166053321,16,1.029287011,0.161328492,-2.631926844,0.00206591,0.001915409,"down","yes","Mrps17","protein_coding","chr12:26948730-26951737:-","gi|157786906|ref|NP_001099393.1|",664,{"v":2e-81,"d":"2.00E-81"},"28S ribosomal protein S17, mitochondrial [Rattus norvegicus]","gi|672072851|ref|XM_006249264.2|",758,0,"PREDICTED: Rattus norvegicus mitochondrial ribosomal protein S17 (Mrps17), transcript variant X1, mRNA","Q9CQE3",230,{"v":2e-71,"d":"2.00E-71"},"28S ribosomal protein S17, mitochondrial",".",".",".",".","pfam00366","Ribosomal_S17","Ribosomal protein S17.","GO:0006412|translation;","GO:0005763|mitochondrial small ribosomal subunit;","GO:0003735|structural constituent of ribosome;","K02961","RP-S17, MRPS17, rpsQ; small subunit ribosomal protein S17"]
["ENSRNOG00000003537",2,0.166053321,16,1.029287011,0.161328492,-2.631926844,0.00206591,0.001915409,"down","yes","Spta1","protein_coding","chr13:86203504-86279371:+","gi|158533972|ref|NP_001011908.2|",11985,0,"spectrin alpha chain, erythrocytic 1 [Rattus norvegicus]","gi|214830975|ref|NM_001011908.3|",7930,0,"Rattus norvegicus spectrin, alpha, erythrocytic 1 (Spta1), mRNA","P08032",4379,0,"Spectrin alpha chain, erythrocytic 1",".",".",".",".","pfam00435","Spectrin","Spectrin repeat. Spectrin repeat-domains are found in several proteins involved in cytoskeletal structure. These include spectrin, alpha-actinin and dystrophin. The sequence repeat used in this family is taken from the structural repeat in reference. The spectrin domain- repeat forms a three helix bundle. The second helix is interrupted by proline in some sequences. The repeats are defined by a characteristic tryptophan (W) residue at position 17 in helix A and a leucine (L) at 2 residues from the carboxyl end of helix C. Although the domain occurs in ultiple repeats along sequences, the domains are actually stable on their own - ie they act, biophysically, like domains rather than repeats that along function when aggregated.","GO:0002260|lymphocyte homeostasis;GO:0006779|porphyrin-containing compound biosynthetic process;GO:0007009|plasma membrane organization;GO:0008150|biological_process;GO:0008360|regulation of cell shape;GO:0030036|actin cytoskeleton organization;GO:0030097|hemopoiesis;GO:0032092|positive regulation of protein binding;GO:0042102|positive regulation of T cell proliferation;GO:0051693|actin filament capping;","GO:0005886|plasma membrane;GO:0008091|spectrin;GO:0009898|cytoplasmic side of plasma membrane;GO:0014731|spectrin-associated cytoskeleton;GO:0016020|membrane;GO:0030054|cell junction;GO:0030424|axon;GO:0030863|cortical cytoskeleton;GO:0030864|cortical actin cytoskeleton;GO:0032437|cuticular plate;GO:0042995|cell projection;","GO:0003674|molecular_function;GO:0003779|actin binding;GO:0005509|calcium ion binding;GO:0051015|actin filament binding;","K06114","SPTA; spectrin alpha"]
["ENSRNOG00000024073",2,0.166053321,16,1.029287011,0.161328492,-2.631926844,0.00206591,0.001915409,"down","yes","Syce1","protein_coding","chr1:195852172-195863174:-","gi|224451138|ref|NP_001020229.2|",1410,0,"synaptonemal complex central element protein 1 [Rattus norvegicus]","gi|224451137|ref|NM_001025058.2|",1446,0,"Rattus norvegicus synaptonemal complex central element protein 1 (Syce1), mRNA","Q5XHZ2",547,0,"Synaptonemal complex central element protein 1",".",".",".",".","pfam15233","SYCE1","Synaptonemal complex central element protein 1. This family of proteins includes synaptonemal complex central element protein 1, a component of the synaptonemal complex involved in meiosis, and synaptonemal complex central element protein 1-like, which may be involved in meiosis.","GO:0007130|synaptonemal complex assembly;GO:0051301|cell division;","GO:0000795|synaptonemal complex;GO:0000801|central element;GO:0005654|nucleoplasm;GO:0005694|chromosome;GO:0005829|cytosol;GO:0043231|intracellular membrane-bounded organelle;",".","K19534","SYCE1; synaptonemal complex central element protein 1"]
["ENSRNOG00000029071",9,0.747239945,33,2.12290446,0.351989437,-1.506395962,0.002087302,1.932584E-3,"down","yes","Unc5c","protein_coding","chr2:230180951-230535217:+","gi|148680122|gb|EDL12069.1|",5035,0,"unc-5 homolog C (C. elegans), isoform CRA_b, partial [Mus musculus]","gi|672044265|ref|XM_006233402.2|",8537,0,"PREDICTED: Rattus norvegicus unc-5 homolog C (C. elegans) (Unc5c), transcript variant X1, mRNA","Q761X5",1832,0,"Netrin receptor UNC5C",".",".",".",".","pfam00791","ZU5","ZU5 domain. Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.","GO:0006915|apoptotic process;GO:0007411|axon guidance;GO:0007420|brain development;GO:0030334|regulation of cell migration;GO:0033564|anterior/posterior axon guidance;GO:0038007|netrin-activated signaling pathway;GO:0043065|positive regulation of apoptotic process;GO:0061643|chemorepulsion of axon;GO:1990791|dorsal root ganglion development;","GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0030027|lamellipodium;GO:0030175|filopodium;GO:0030424|axon;GO:0030425|dendrite;GO:0030426|growth cone;GO:0043025|neuronal cell body;GO:0045202|synapse;","GO:0005042|netrin receptor activity;GO:0005043|netrin receptor activity involved in chemorepulsion;GO:0015631|tubulin binding;GO:0019901|protein kinase binding;","K07521","UNC5; netrin receptor unc-5"]
["ENSRNOG00000027869",16,1.328426568,47,3.023530595,0.439362701,-1.186515695,0.002230114,0.00205393,"down","yes","Sox5","protein_coding","chr4:176785892-177736852:-","gi|672051312|ref|XP_008761571.1|",2855,0,"PREDICTED: transcription factor SOX-5 isoform X2 [Rattus norvegicus]","gi|672051311|ref|XM_008763349.1|",2583,0,"PREDICTED: Rattus norvegicus SRY (sex determining region Y)-box 5 (Sox5), transcript variant X2, mRNA","P35710",1067,0,"Transcription factor SOX-5","SPAC57A10.09c",52,9e-07,"COG5648","pfam00505","HMG_box","HMG (high mobility group) box.","GO:0001502|cartilage condensation;GO:0001701|in utero embryonic development;GO:0002062|chondrocyte differentiation;GO:0006357|regulation of transcription by RNA polymerase II;GO:0021953|central nervous system neuron differentiation;GO:0032332|positive regulation of chondrocyte differentiation;GO:0045165|cell fate commitment;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048709|oligodendrocyte differentiation;GO:0051216|cartilage development;GO:0055059|asymmetric neuroblast division;GO:0060164|regulation of timing of neuron differentiation;GO:0061036|positive regulation of cartilage development;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:2000741|positive regulation of mesenchymal stem cell differentiation;","GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987|proximal promoter sequence-specific DNA binding;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;","K09269","SOX5_6_13; transcription factor SOX5/6/13 (SOX group D)"]
["ENSRNOG00000061358",12,0.996319926,39,2.508887089,0.397116287,-1.332366562,0.002290653,0.002104105,"down","yes","AC129365.1","protein_coding","chr2:141551434-141554016:+","gi|274321177|ref|NP_387500.1|",3531,0,"DNA replication licensing factor MCM4 [Rattus norvegicus]","gi|672071696|ref|XR_358444.2|",2005,0,"PREDICTED: Rattus norvegicus minichromosome maintenance complex component 4 (Mcm4), transcript variant X2, misc_RNA","P49717",1340,0,"DNA replication licensing factor MCM4","YPR019w",558,0,"COG1241","pfam00493","MCM","MCM2/3/5 family.",".",".",".",".","."]
["ENSRNOG00000008996",14,1.162373247,43,2.766208842,0.420204444,-1.250836676,2.295231E-3,0.002107704,"down","yes","Dpysl5","protein_coding","chr6:25575104-25659422:-","gi|12711692|ref|NP_075412.1|",3035,0,"dihydropyrimidinase-related protein 5 [Rattus norvegicus]","gi|12711691|ref|NM_023023.1|",4836,0,"Rattus norvegicus dihydropyrimidinase-like 5 (Dpysl5), mRNA","Q9JHU0",1173,0,"Dihydropyrimidinase-related protein 5","SMc01821",404,{"v":1e-124,"d":"1.00E-124"},"COG0044","pfam13594","Amidohydro_5","Amidohydrolase. This family of enzymes are a part of a large metal dependent hydrolase superfamily. The family includes Adenine deaminase EC:3.5.4.2 that hydrolyses adenine to form hypoxanthine and ammonia. Adenine deaminases reaction is important for adenine utilisation as a purine and also as a nitrogen source. This family also includes dihydroorotase and N-acetylglucosamine-6-phosphate deacetylases, EC:3.5.1.25 These enzymes catalyse the reaction N-acetyl-D-glucosamine 6-phosphate + H2O <=> D-glucosamine 6-phosphate + acetate. This family includes the catalytic domain of urease alpha subunit. Dihydroorotases (EC:3.5.2.3) are also included.","GO:0007411|axon guidance;GO:0030182|neuron differentiation;","GO:0005737|cytoplasm;GO:0030425|dendrite;GO:0032991|protein-containing complex;GO:0043025|neuronal cell body;","GO:0005515|protein binding;GO:0008017|microtubule binding;","K07529","DPYSL5, CRAM; dihydropyrimidinase-like 5"]
["ENSRNOG00000013515",23,1.909613192,60,3.859826291,0.494740708,-1.015255483,0.002325128,0.002133321,"down","yes","Ptpru","protein_coding","chr5:143950965-144024768:-","gi|564353148|ref|XP_006239059.1|",7099,0,"PREDICTED: receptor-type tyrosine-protein phosphatase U isoform X1 [Rattus norvegicus]","gi|672054043|ref|XM_006238997.2|",4889,0,"PREDICTED: Rattus norvegicus protein tyrosine phosphatase, receptor type, U (Ptpru), transcript variant X1, mRNA","B1AUH1",2706,0,"Receptor-type tyrosine-protein phosphatase U","SPAC11E3.09",137,{"v":3e-33,"d":"3.00E-33"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0006470|protein dephosphorylation;GO:0008285|negative regulation of cell proliferation;GO:0030182|neuron differentiation;GO:0030336|negative regulation of cell migration;GO:0031100|animal organ regeneration;GO:0034109|homotypic cell-cell adhesion;GO:0034394|protein localization to cell surface;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0051384|response to glucocorticoid;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:2000049|positive regulation of cell-cell adhesion mediated by cadherin;","GO:0005575|cellular_component;GO:0005911|cell-cell junction;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0004725|protein tyrosine phosphatase activity;GO:0008013|beta-catenin binding;","K16662","PTPRU; receptor-type tyrosine-protein phosphatase U [EC:3.1.3.48]"]
["ENSRNOG00000000412",22,1.826586532,58,3.731165415,0.489548527,-1.03047622,0.002438143,0.002222977,"down","yes","Slc35f1","protein_coding","chr20:32030368-32418611:+","gi|157819029|ref|NP_001102808.1|",2013,0,"solute carrier family 35 member F1 [Rattus norvegicus]","gi|157819028|ref|NM_001109338.1|",4773,0,"Rattus norvegicus solute carrier family 35, member F1 (Slc35f1), mRNA","Q8BGK5",768,0,"Solute carrier family 35 member F1","SPCC320.08",191,{"v":2E-50,"d":"2.00E-50"},"COG0697","pfam06027","DUF914","Eukaryotic protein of unknown function (DUF914). This family consists of several hypothetical proteins of unknown function. Some of the sequences in this family are annotated as being putative membrane proteins.","GO:0055085|transmembrane transport;","GO:0016021|integral component of membrane;","GO:0022857|transmembrane transporter activity;","K15287","SLC35F1_2; solute carrier family 35, member F1/2"]
["ENSRNOG00000016854",22,1.826586532,58,3.731165415,0.489548527,-1.03047622,0.002438143,0.002222977,"down","yes","Lrrc36","protein_coding","chr19:33292074-33360141:+","gi|282847351|ref|NP_001004088.3|",2644,0,"leucine-rich repeat-containing protein 36 [Rattus norvegicus]","gi|226192806|gb|AC116220.6|",3331,0,"Rattus norvegicus CH230-256P17 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q3V0M2",917,0,"Leucine-rich repeat-containing protein 36",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.",".",".",".","K16594","LRRC36; leucine-rich repeat-containing protein 36"]
["ENSRNOG00000047817",22,1.826586532,58,3.731165415,0.489548527,-1.03047622,0.002438143,0.002222977,"down","yes","Enox1","protein_coding","chr15:52515178-53079749:+","gi|672028764|ref|XP_008768296.1|",3166,0,"PREDICTED: ecto-NOX disulfide-thiol exchanger 1 isoform X3 [Rattus norvegicus]","gi|298915862|emb|FQ222793.1|",3448,0,"Rattus norvegicus TL0ADA19YN23 mRNA sequence","Q8BHR2",1165,0,"Ecto-NOX disulfide-thiol exchanger 1",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0007624|ultradian rhythm;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;","GO:0003674|molecular_function;GO:0003723|RNA binding;GO:0003756|protein disulfide isomerase activity;GO:0003954|NADH dehydrogenase activity;GO:0015035|protein disulfide oxidoreductase activity;","K24982","ENOX; ecto-NOX disulfide-thiol exchanger"]
["ENSRNOG00000049849",4,0.332106642,21,1.350939202,0.245833892,-2.024244267,2.562857E-3,0.002325529,"down","yes","ENSRNOG00000049849","protein_coding","chrX:100384225-100414938:+","gi|148691944|gb|EDL23891.1|",1665,0,"cDNA sequence BC031748, partial [Mus musculus]","gi|274320576|ref|NM_146261.2|",2018,0,"Mus musculus family with sequence similarity 199, X-linked (Fam199x), mRNA",".",".",".",".",".",".",".",".","pfam06278","DUF1032","Protein of unknown function (DUF1032). This family consists of several conserved eukaryotic proteins of unknown function.",".",".",".",".","."]
["ENSRNOG00000067525",19,1.57750655,52,3.345182786,0.471575591,-1.084439049,2.771202E-3,0.002495683,"down","yes","ENSRNOG00000067525","lncRNA","chr1:202046375-202047792:-","gi|149060708|gb|EDM11422.1|",131,1e-06,"rCG52991, isoform CRA_d [Rattus norvegicus]","gi|229220813|gb|AC126581.3|",908,0,"Rattus norvegicus CH230-12O23 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam11913","DUF3431","Protein of unknown function (DUF3431). This family of proteins are functionally uncharacterized. This protein is found in eukaryotes. Proteins in this family are typically between 291 to 390 amino acids in length. This protein has a conserved NLRC sequence motif.",".",".",".",".","."]
["ENSRNOG00000000277",8,0.664213284,30,1.929913146,0.344167449,-1.538817439,0.002876267,2.584842E-3,"down","yes","Tet1","protein_coding","chr20:25768120-25833052:+","gi|564322123|ref|XP_006223942.1|",10446,0,"PREDICTED: methylcytosine dioxygenase TET1 [Rattus norvegicus]","gi|672031733|ref|XM_008774952.1|",5241,0,"PREDICTED: Rattus norvegicus tet methylcytosine dioxygenase 1 (Tet1), transcript variant X2, mRNA","Q3URK3",3193,0,"Methylcytosine dioxygenase TET1",".",".",".",".","pfam12851","Tet_JBP","Oxygenase domain of the 2OGFeDO superfamily. A double-stranded beta helix (DSBH) fold domain of the 2-oxoglutarate (2OG)-Fe(II)-dependent dioxygenase (2OGFeDO) superfamily found in various eukaryotes, bacteria and bacteriophages. Members of this family catalyze nucleic acid modifications, such as thymidine hydroxylation during base J synthesis in kinetoplastids, and the conversion of 5 methyl-cytosine (5-mC) to 5-hydroxymethyl-cytosine (hmC), or further oxidation to 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). Metazoan TET proteins contain a cysteine-rich region inserted into the core of the DSBH fold. Vertebrate TET proteins are oncogenes that are mutated in various myeloid cancers. Fungal and algal versions of this family are linked to a predicted transposase and show lineage-specific expansions.","GO:0001826|inner cell mass cell differentiation;GO:0006211|5-methylcytosine catabolic process;GO:0006493|protein O-linked glycosylation;GO:0008150|biological_process;GO:0008284|positive regulation of cell proliferation;GO:0019827|stem cell population maintenance;GO:0031062|positive regulation of histone methylation;GO:0044030|regulation of DNA methylation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048813|dendrite morphogenesis;GO:0070989|oxidative demethylation;GO:0080111|DNA demethylation;GO:0090310|negative regulation of methylation-dependent chromatin silencing;GO:2000653|regulation of genetic imprinting;","GO:0005575|cellular_component;GO:0005634|nucleus;","GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0005506|iron ion binding;GO:0008270|zinc ion binding;GO:0008327|methyl-CpG binding;GO:0070579|methylcytosine dioxygenase activity;","K13097","TET1; methylcytosine dioxygenase [EC:1.14.11.-]"]
["ENSRNOG00000062835",8,0.664213284,30,1.929913146,0.344167449,-1.538817439,0.002876267,2.584842E-3,"down","yes","ENSRNOG00000062835","protein_coding","chr5:60256314-60276810:-","gi|37361874|gb|AAQ91050.1|",282,{"v":1e-24,"d":"1.00E-24"},"LRRGT00094 [Rattus norvegicus]","gi|401461827|gb|AC246663.5|",855,0,"Rattus norvegicus Y Chr BAC RNECO-121H12 (Amplicon Express Rat SHR-Akr (EcoR1 Digest) BAC library) complete sequence","P31789",91.3,{"v":6e-18,"d":"6.00E-18"},"Envelope glycoprotein",".",".",".",".","pfam01500","Keratin_B2","Keratin, high sulfur B2 protein. High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.",".",".",".",".","."]
["ENSRNOG00000067844",17,1.411453229,48,3.087861033,0.457097393,-1.129426503,0.002971573,0.002665247,"down","yes","ENSRNOG00000067844","protein_coding","chrX:19563517-19572953:-","gi|595582214|ref|NP_001277700.1|",1229,{"v":4E-160,"d":"4.00E-160"},"trophinin isoform 4 [Mus musculus]","gi|672032140|ref|XM_008758390.1|",754,0,"PREDICTED: Rattus norvegicus trophinin-like (LOC100912141), transcript variant X2, mRNA","Q12816",434,{"v":2e-139,"d":"2.00E-139"},"Trophinin",".",".",".",".","pfam01454","MAGE","MAGE family. The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumors but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.",".",".",".",".","."]
["ENSRNOG00000065957",5,0.415133303,23,1.479600078,0.28057129,-1.833560705,0.003127731,0.002791602,"down","yes","ENSRNOG00000065957","lncRNA","chr1:258564709-258606618:-","gi|149040521|gb|EDL94559.1|",215,{"v":8e-17,"d":"8.00E-17"},"rCG57731 [Rattus norvegicus]","gi|24476171|gb|AC098733.2|",1351,0,"Mus musculus BAC clone RP23-103C10 from 19, complete sequence",".",".",".",".",".",".",".",".","pfam10063","DUF2301","Uncharacterized integral membrane protein (DUF2301). This domain, found in various hypothetical bacterial proteins, has no known function.",".",".",".",".","."]
["ENSRNOG00000070845",5,0.415133303,23,1.479600078,0.28057129,-1.833560705,0.003127731,0.002791602,"down","yes","ENSRNOG00000070845","lncRNA","chr4:125689911-125697538:-",".",".",".",".","gi|672018575|ref|XR_345989.2|",288,{"v":3e-147,"d":"3.00E-147"},"PREDICTED: Rattus norvegicus uncharacterized LOC102555860 (LOC102555860), ncRNA",".",".",".",".",".",".",".",".","pfam00606","Glycoprotein_B","Herpesvirus Glycoprotein B. This family of proteins contains a transmembrane region.",".",".",".",".","."]
["ENSRNOG00000033570",15,1.245399908,44,2.83053928,0.439986796,-1.184467867,0.003131889,0.002794533,"down","yes","Arhgap8","protein_coding","chr7:115850654-115902093:+","gi|51948456|ref|NP_001004242.1|",2166,0,"rho GTPase-activating protein 8 [Rattus norvegicus]","gi|51948455|ref|NM_001004242.1|",1516,0,"Rattus norvegicus Rho GTPase activating protein 8 (Arhgap8), mRNA","Q9CXP4",813,0,"Rho GTPase-activating protein 8",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0007165|signal transduction;GO:0050790|regulation of catalytic activity;GO:0070374|positive regulation of ERK1 and ERK2 cascade;",".","GO:0005096|GTPase activator activity;","K20633","ARHGAP8, BPGAP1; Rho GTPase-activating protein 8"]
["ENSRNOG00000070148",15,1.245399908,44,2.83053928,0.439986796,-1.184467867,0.003131889,0.002794533,"down","yes","ENSRNOG00000070148","lncRNA","chrX:21421921-21430797:-","gi|149038339|gb|EDL92699.1|",211,{"v":4e-16,"d":"4.00E-16"},"rCG63222 [Rattus norvegicus]","gi|13173603|gb|AC084214.19|AC084214",856,0,"Mus musculus X BAC RP23-382J5 (Roswell Park Cancer Institute Mouse BAC Library) complete sequence",".",".",".",".",".",".",".",".","pfam01529","zf-DHHC","DHHC palmitoyltransferase. This family includes the well known DHHC zinc binding domain as well as three of the four conserved transmembrane regions found in this family of palmitoyltransferase enzymes.",".",".",".",".","."]
["ENSRNOG00000011688",10,0.830266605,34,2.187234898,0.379596451,-1.39746159,0.003145708,0.002804906,"down","yes","Neil3","protein_coding","chr16:38359371-38418527:+","gi|281332206|ref|NP_001163817.1|",3131,0,"endonuclease 8-like 3 [Rattus norvegicus]","gi|281332205|ref|NM_001170346.1|",1883,0,"Rattus norvegicus nei-like DNA glycosylase 3 (Neil3), mRNA","Q8K203",1031,0,"Endonuclease 8-like 3","Rv3297",75.1,{"v":5e-14,"d":"5.00E-14"},"COG0266","pfam06839","zf-GRF","GRF zinc finger. This presumed zinc binding domain is found in a variety of DNA-binding proteins. It seems likely that this domain is involved in nucleic acid binding. It is named GRF after three conserved residues in the centre of the alignment of the domain. This zinc finger may be related to pfam01396.","GO:0006284|base-excision repair;","GO:0005634|nucleus;GO:0005654|nucleoplasm;","GO:0000405|bubble DNA binding;GO:0003684|damaged DNA binding;GO:0003690|double-stranded DNA binding;GO:0003697|single-stranded DNA binding;GO:0003906|DNA-(apurinic or apyrimidinic site) endonuclease activity;GO:0008270|zinc ion binding;GO:0019104|DNA N-glycosylase activity;GO:0140078|class I DNA-(apurinic or apyrimidinic site) endonuclease activity;","K10569","NEIL3; endonuclease VIII-like 3"]
["ENSRNOG00000002484",1,0.083026661,12,0.771965258,0.107552328,-3.216889345,0.003214099,0.00285752,"down","yes","Chrna9","protein_coding","chr14:42235226-42242192:-","gi|68067466|sp|P43144.2|ACHA9_RAT",2455,0,"RecName: Full=Neuronal acetylcholine receptor subunit alpha-9; AltName: Full=Nicotinic acetylcholine receptor subunit alpha-9; Short=NACHR alpha-9; Flags: Precursor","gi|12621087|ref|NM_022930.1|",1769,0,"Rattus norvegicus cholinergic receptor nicotinic alpha 9 subunit (Chrna9), mRNA","P43144",950,0,"Neuronal acetylcholine receptor subunit alpha-9",".",".",".",".","pfam02931","Neur_chan_LBD","Neurotransmitter-gated ion-channel ligand binding domain. This family is the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.","GO:0006812|cation transport;GO:0007165|signal transduction;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007268|chemical synaptic transmission;GO:0007605|sensory perception of sound;GO:0034220|ion transmembrane transport;GO:0042391|regulation of membrane potential;GO:0042472|inner ear morphogenesis;GO:0050877|nervous system process;GO:0050910|detection of mechanical stimulus involved in sensory perception of sound;GO:0060079|excitatory postsynaptic potential;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0070588|calcium ion transmembrane transport;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005892|acetylcholine-gated channel complex;GO:0043005|neuron projection;GO:0045202|synapse;GO:0098981|cholinergic synapse;GO:0099060|integral component of postsynaptic specialization membrane;","GO:0004888|transmembrane signaling receptor activity;GO:0005262|calcium channel activity;GO:0022848|acetylcholine-gated cation-selective channel activity;GO:0030594|neurotransmitter receptor activity;GO:1904315|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K04810","CHRNA9; nicotinic acetylcholine receptor alpha-9"]
["ENSRNOG00000016483",1,0.083026661,12,0.771965258,0.107552328,-3.216889345,0.003214099,0.00285752,"down","yes","Myo16","protein_coding","chr16:78884406-79248388:-","gi|672080674|ref|XP_008769606.1|",9059,0,"PREDICTED: unconventional myosin-XVI isoform X1 [Rattus norvegicus]","gi|672080673|ref|XM_008771384.1|",6836,0,"PREDICTED: Rattus norvegicus myosin XVI (Myo16), transcript variant X1, mRNA","Q9ERC1",3476,0,"Unconventional myosin-XVI","YAL029c",321,{"v":3e-88,"d":"3.00E-88"},"COG5022","pfam00063","Myosin_head","Myosin head (motor domain).","GO:0008285|negative regulation of cell proliferation;GO:0014065|phosphatidylinositol 3-kinase signaling;GO:0021549|cerebellum development;GO:0048812|neuron projection morphogenesis;GO:2000134|negative regulation of G1/S transition of mitotic cell cycle;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016459|myosin complex;GO:0048471|perinuclear region of cytoplasm;","GO:0003774|motor activity;GO:0003779|actin binding;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0019903|protein phosphatase binding;GO:0044877|protein-containing complex binding;GO:0051015|actin filament binding;","K17481","MYO16; myosin XVI"]
["ENSRNOG00000016628",1,0.083026661,12,0.771965258,0.107552328,-3.216889345,0.003214099,0.00285752,"down","yes","Scgn","protein_coding","chr17:41106467-41148667:+","gi|672081799|ref|XP_008769875.1|",1452,0,"PREDICTED: secretagogin isoform X1 [Rattus norvegicus]","gi|672081798|ref|XM_008771653.1|",1477,0,"PREDICTED: Rattus norvegicus secretagogin, EF-hand calcium binding protein (Scgn), transcript variant X1, mRNA","Q6R556",560,0,"Secretagogin",".",".",".",".","pfam13499","EF-hand_7","EF-hand domain pair.","GO:0051480|regulation of cytosolic calcium ion concentration;GO:0099509|regulation of presynaptic cytosolic calcium ion concentration;GO:1900271|regulation of long-term synaptic potentiation;","GO:0005576|extracellular region;GO:0005634|nucleus;GO:0005829|cytosol;GO:0030425|dendrite;GO:0030658|transport vesicle membrane;GO:0043005|neuron projection;GO:0043195|terminal bouton;GO:0045202|synapse;","GO:0005509|calcium ion binding;","K23928","SCGN; secretagogin"]
["ENSRNOG00000017444",1,0.083026661,12,0.771965258,0.107552328,-3.216889345,0.003214099,0.00285752,"down","yes","Nrsn1","protein_coding","chr17:39806238-39823813:+","gi|148700512|gb|EDL32459.1|",979,{"v":1E-127,"d":"1.00E-127"},"neurensin 1, isoform CRA_b, partial [Mus musculus]","gi|187937119|ref|NM_001106109.2|",1373,0,"Rattus norvegicus neurensin 1 (Nrsn1), mRNA","P97799",334,{"v":2e-111,"d":"2.00E-111"},"Neurensin-1",".",".",".",".","pfam14927","Neurensin","Neurensin. The neurensin family includes the neuronal membrane proteins neurensin-1 and neurensin-2. Neurensin-1 plays a role in neurite extension.","GO:0007399|nervous system development;","GO:0016021|integral component of membrane;GO:0030133|transport vesicle;GO:0030426|growth cone;GO:0031410|cytoplasmic vesicle;GO:0043005|neuron projection;GO:0043025|neuronal cell body;",".",".","."]
["ENSRNOG00000020066",1,0.083026661,12,0.771965258,0.107552328,-3.216889345,0.003214099,0.00285752,"down","yes","Pcdhb11","protein_coding","chr18:29126669-29129062:+","gi|109506480|ref|XP_001055576.1|",3818,0,"PREDICTED: protocadherin-3 [Rattus norvegicus]","gi|564320525|ref|XM_001064927.4|",2394,0,"PREDICTED: Rattus norvegicus protocadherin beta 11 (Pcdhb11), mRNA","Q63418",1223,0,"Protocadherin-3",".",".",".",".","pfam08266","Cadherin_2","Cadherin-like. This cadherin domain is usually the most N-terminal copy of the domain.","GO:0007155|cell adhesion;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005887|integral component of plasma membrane;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;","K16494","PCDHB; protocadherin beta"]
["ENSRNOG00000055965",1,0.083026661,12,0.771965258,0.107552328,-3.216889345,0.003214099,0.00285752,"down","yes","U6","snRNA","chr2:174157426-174157535:-",".",".",".",".","gi|937346970|ref|NG_044746.1|",46,{"v":6e-14,"d":"6.00E-14"},"Homo sapiens RNA, U6 small nuclear 869, pseudogene (RNU6-869P) on chromosome 8",".",".",".",".",".",".",".",".","pfam08298","AAA_PrkA","PrkA AAA domain. This is a family of PrkA bacterial and archaeal serine kinases approximately 630 residues long. This is the N-terminal AAA domain.",".",".",".",".","."]
["ENSRNOG00000059753",1,0.083026661,12,0.771965258,0.107552328,-3.216889345,0.003214099,0.00285752,"down","yes","Gys2","protein_coding","chr4:175365054-175406228:-","gi|752993063|ref|NP_037221.2|",3501,0,"glycogen [starch] synthase, liver [Rattus norvegicus]","gi|752993062|ref|NM_013089.2|",2574,0,"Rattus norvegicus glycogen synthase 2 (Gys2), mRNA","P17625",1349,0,"Glycogen [starch] synthase, liver","YFR015c",671,0,"COG0438","pfam05693","Glycogen_syn","Glycogen synthase. This family consists of the eukaryotic glycogen synthase proteins GYS1, GYS2 and GYS3. Glycogen synthase (GS) is the enzyme responsible for the synthesis of -1,4-linked glucose chains in glycogen. It is the rate limiting enzyme in the synthesis of the polysaccharide, and its activity is highly regulated through phosphorylation at multiple sites and also by allosteric effectors, mainly glucose 6-phosphate (G6P).","GO:0005977|glycogen metabolic process;GO:0005978|glycogen biosynthetic process;GO:0009749|response to glucose;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0005938|cell cortex;GO:0030864|cortical actin cytoskeleton;GO:0043265|ectoplasm;","GO:0004373|glycogen (starch) synthase activity;GO:0005536|glucose binding;","K00693","GYS; glycogen synthase [EC:2.4.1.11]"]
["ENSRNOG00000064054",1,0.083026661,12,0.771965258,0.107552328,-3.216889345,0.003214099,0.00285752,"down","yes","ENSRNOG00000064054","lncRNA","chr7:108757729-108759258:-",".",".",".",".","gi|672022071|ref|XR_601909.1|",784,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102556690 (LOC102556690), ncRNA",".",".",".",".",".",".",".",".","pfam08670","MEKHLA","MEKHLA domain. The MEKHLA domain shares similarity with the PAS domain and is found in the 3' end of plant HD-ZIP III homeobox genes, and bacterial proteins.",".",".",".",".","."]
["ENSRNOG00000004679",21,1.743559871,55,3.5381741,0.492785211,-1.020969135,0.003399677,0.003009537,"down","yes","Fign","protein_coding","chr3:48642496-48760787:-","gi|157817141|ref|NP_001099954.1|",3512,0,"fidgetin [Rattus norvegicus]","gi|672045768|ref|XM_008761890.1|",3414,0,"PREDICTED: Rattus norvegicus fidgetin (Fign), transcript variant X3, mRNA","Q9ERZ6",1350,0,"Fidgetin","ECU11g1030",279,{"v":3e-82,"d":"3.00E-82"},"COG0464","pfam00004","AAA","ATPase family associated with various cellular activities (AAA). AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.","GO:0007626|locomotory behavior;GO:0051013|microtubule severing;","GO:0016363|nuclear matrix;","GO:0005524|ATP binding;GO:0008022|protein C-terminus binding;GO:0008568|microtubule-severing ATPase activity;",".","."]
["ENSRNOG00000001287",2,0.166053321,15,0.964956573,0.172083725,-2.538817439,0.003455126,0.003051862,"down","yes","Gper1","protein_coding","chr12:15217442-15221889:-","gi|564378353|ref|XP_006248976.1|",1905,0,"PREDICTED: G-protein coupled estrogen receptor 1 isoform X1 [Rattus norvegicus]","gi|672071889|ref|XM_006248914.2|",2147,0,"PREDICTED: Rattus norvegicus G protein-coupled estrogen receptor 1 (Gper1), transcript variant X1, mRNA","O08878",736,0,"G-protein coupled estrogen receptor 1",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001934|positive regulation of protein phosphorylation;GO:0001956|positive regulation of neurotransmitter secretion;GO:0002695|negative regulation of leukocyte activation;GO:0006954|inflammatory response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007210|serotonin receptor signaling pathway;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010948|negative regulation of cell cycle process;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0019228|neuronal action potential;GO:0030263|apoptotic chromosome condensation;GO:0030264|nuclear fragmentation involved in apoptotic nuclear change;GO:0030335|positive regulation of cell migration;GO:0030518|intracellular steroid hormone receptor signaling pathway;GO:0030520|intracellular estrogen receptor signaling pathway;GO:0032024|positive regulation of insulin secretion;GO:0032962|positive regulation of inositol trisphosphate biosynthetic process;GO:0042307|positive regulation of protein import into nucleus;GO:0042311|vasodilation;GO:0043065|positive regulation of apoptotic process;GO:0043280|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043401|steroid hormone mediated signaling pathway;GO:0043410|positive regulation of MAPK cascade;GO:0045087|innate immune response;GO:0045599|negative regulation of fat cell differentiation;GO:0045742|positive regulation of epidermal growth factor receptor signaling pathway;GO:0045745|positive regulation of G protein-coupled receptor signaling pathway;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050728|negative regulation of inflammatory response;GO:0050769|positive regulation of neurogenesis;GO:0050804|modulation of chemical synaptic transmission;GO:0051055|negative regulation of lipid biosynthetic process;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;GO:0051480|regulation of cytosolic calcium ion concentration;GO:0051726|regulation of cell cycle;GO:0051897|positive regulation of protein kinase B signaling;GO:0051898|negative regulation of protein kinase B signaling;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070474|positive regulation of uterine smooth muscle contraction;GO:0071333|cellular response to glucose stimulus;GO:0071356|cellular response to tumor necrosis factor;GO:0071375|cellular response to peptide hormone stimulus;GO:0071389|cellular response to mineralocorticoid stimulus;GO:0071392|cellular response to estradiol stimulus;GO:0090200|positive regulation of release of cytochrome c from mitochondria;GO:1900121|negative regulation of receptor binding;GO:1903078|positive regulation of protein localization to plasma membrane;GO:1904706|negative regulation of vascular smooth muscle cell proliferation;GO:1904753|negative regulation of vascular associated smooth muscle cell migration;GO:1905152|positive regulation of voltage-gated sodium channel activity;GO:2000353|positive regulation of endothelial cell apoptotic process;GO:2000724|positive regulation of cardiac vascular smooth muscle cell differentiation;GO:2001238|positive regulation of extrinsic apoptotic signaling pathway;","GO:0000139|Golgi membrane;GO:0005634|nucleus;GO:0005635|nuclear envelope;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005769|early endosome;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005794|Golgi apparatus;GO:0005802|trans-Golgi network;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0030659|cytoplasmic vesicle membrane;GO:0031966|mitochondrial membrane;GO:0032591|dendritic spine membrane;GO:0042734|presynaptic membrane;GO:0043025|neuronal cell body;GO:0043198|dendritic shaft;GO:0043231|intracellular membrane-bounded organelle;GO:0043679|axon terminus;GO:0044327|dendritic spine head;GO:0045095|keratin filament;GO:0048471|perinuclear region of cytoplasm;GO:0048786|presynaptic active zone;GO:0055037|recycling endosome;GO:0098686|hippocampal mossy fiber to CA3 synapse;","GO:0003682|chromatin binding;GO:0003707|steroid hormone receptor activity;GO:0004930|G protein-coupled receptor activity;GO:0005496|steroid binding;GO:0030284|estrogen receptor activity;GO:1903924|estradiol binding;GO:1990239|steroid hormone binding;","K04246","GPER1, GPR30; G-protein coupled estrogen receptor 1"]
["ENSRNOG00000029321",2,0.166053321,15,0.964956573,0.172083725,-2.538817439,0.003455126,0.003051862,"down","yes","Ccser1","protein_coding","chr4:90292780-91388786:+","gi|256222323|ref|NP_899133.2|",3839,0,"serine-rich coiled-coil domain-containing protein 1 [Mus musculus]","gi|256222359|ref|NM_001164316.1|",2645,0,"Mus musculus coiled-coil serine rich 1 (Ccser1), transcript variant 2, mRNA",".",".",".",".",".",".",".",".","pfam13870","DUF4201","Domain of unknown function (DUF4201). This is a family of coiled-coil proteins from eukaryotes. The function is not known.",".",".",".",".","."]
["ENSRNOG00000068054",2,0.166053321,15,0.964956573,0.172083725,-2.538817439,0.003455126,0.003051862,"down","yes","ENSRNOG00000068054","lncRNA","chrX:19419114-19461465:-",".",".",".",".","gi|22859064|emb|AL808140.5|",391,0,"Mouse DNA sequence from clone RP23-147K5 on chromosome X, complete sequence",".",".",".",".",".",".",".",".","pfam01728","FtsJ","FtsJ-like methyltransferase. This family consists of FtsJ from various bacterial and archaeal sources FtsJ is a methyltransferase, but actually has no effect on cell division. FtsJ's substrate is the 23S rRNA. The 1.5 A crystal structure of FtsJ in complex with its cofactor S-adenosylmethionine revealed that FtsJ has a methyltransferase fold. This family also includes the N terminus of flaviviral NS5 protein. It has been hypothesised that the N-terminal domain of NS5 is a methyltransferase involved in viral RNA capping.",".",".",".",".","."]
["ENSRNOG00000003349",20,1.66053321,53,3.409513224,0.487029409,-1.037919203,0.003562669,0.003139914,"down","yes","Col23a1","protein_coding","chr10:35549113-35836314:+","gi|119574218|gb|EAW53833.1|",623,{"v":3E-102,"d":"3.00E-102"},"collagen, type XXIII, alpha 1, isoform CRA_a [Homo sapiens]","gi|31795568|ref|NM_181636.2|",2719,0,"Rattus norvegicus collagen, type XXIII, alpha 1 (Col23a1), mRNA","Q810Y4",315,{"v":2e-94,"d":"2.00E-94"},"Collagen alpha-1(XXIII) chain",".",".",".",".","pfam01391","Collagen","Collagen triple helix repeat (20 copies). Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxyproline. Collagens are post translationally modified by proline hydroxylase to form the hydroxyproline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure.","GO:0030198|extracellular matrix organization;","GO:0005581|collagen trimer;GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0031012|extracellular matrix;","GO:0005201|extracellular matrix structural constituent;GO:0008201|heparin binding;GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000047473",6,0.498159963,25,1.608260955,0.309750704,-1.690820533,0.003591101,0.003159746,"down","yes","Dchs2","protein_coding","chr2:168478826-168682732:+","gi|564300462|ref|XP_006224215.1|",16915,0,"PREDICTED: protocadherin-23-like [Rattus norvegicus]","gi|672042786|ref|XM_006232535.2|",10044,0,"PREDICTED: Rattus norvegicus dachsous cadherin-related 2 (Dchs2), mRNA","Q6V1P9",3657,0,"Protocadherin-23",".",".",".",".","pfam00028","Cadherin","Cadherin domain.",".",".",".",".","."]
["ENSRNOG00000048039",6,0.498159963,25,1.608260955,0.309750704,-1.690820533,0.003591101,0.003159746,"down","yes","ENSRNOG00000048039","protein_coding","chr19:59989-74331:-","gi|155369680|ref|NP_001094469.1|",2977,0,"carboxylesterase 2-like precursor [Rattus norvegicus]","gi|155369679|ref|NM_001100999.1|",1895,0,"Rattus norvegicus similar to carboxylesterase 2 (intestine, liver) (LOC679149), mRNA","Q91WG0",974,0,"Acylcarnitine hydrolase","BS_pnbA",266,{"v":6e-80,"d":"6.00E-80"},"COG2272","pfam00135","COesterase","Carboxylesterase family.",".","GO:0043231|intracellular membrane-bounded organelle;","GO:0052689|carboxylic ester hydrolase activity;","K03927","CES2; carboxylesterase 2 [EC:3.1.1.1 3.1.1.84 3.1.1.56]"]
["ENSRNOG00000067276",6,0.498159963,25,1.608260955,0.309750704,-1.690820533,0.003591101,0.003159746,"down","yes","ENSRNOG00000067276","protein_coding","chr9:113440096-113461706:+","gi|148705231|gb|EDL37178.1|",2152,0,"mCG23594 [Mus musculus]","gi|672018984|ref|XR_600914.1|",1748,0,"PREDICTED: Rattus norvegicus zinc finger protein 120-like (LOC102557117), misc_RNA","A6NN14",759,0,"Zinc finger protein 729","SPAC144.09c",106,{"v":2e-23,"d":"2.00E-23"},"COG5048","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000067703",6,0.498159963,25,1.608260955,0.309750704,-1.690820533,0.003591101,0.003159746,"down","yes","ENSRNOG00000067703","lncRNA","chr7:110736200-110790539:+","gi|149065945|gb|EDM15818.1|",168,{"v":2E-12,"d":"2.00E-12"},"rCG59673 [Rattus norvegicus]","gi|672060372|ref|XR_593650.1|",435,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102550290 (LOC102550290), transcript variant X3, ncRNA",".",".",".",".",".",".",".",".","pfam15351","JCAD","Junctional protein associated with coronary artery disease. JCAD is a component of VE-cadherin-based cell-cell junctions in endothelial cells. The cell-cell or adherens junction is an adhesion complex that plays a crucial role in the organisation and function of epithelial and endothelial cellular sheets. These junctions join the actin cytoskeleton to the plasma membrane to form adhesive contacts between cells or between cells and extracellular matrix. The junctions also mediate both cell adhesion and cell-signalling. JCAD localizes close to the apical membrane in epithelial cells. This family is found in eukaryotes.",".",".",".",".","."]
["ENSRNOG00000013062",0,0.04151333,10,0.643304382,0.064531397,-3.953854939,0.003618725,0.003178322,"down","yes","Cyp24a1","protein_coding","chr3:159275947-159290383:-","gi|42761472|ref|NP_963966.1|",2756,0,"1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial precursor [Rattus norvegicus]","gi|71682172|gb|BC100059.1|",3212,0,"Rattus norvegicus cytochrome P450, subfamily 24, mRNA (cDNA clone MGC:112576 IMAGE:7129117), complete cds","Q09128",1066,0,"1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial","BH0579",129,{"v":9e-31,"d":"9.00E-31"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0001649|osteoblast differentiation;GO:0010430|fatty acid omega-oxidation;GO:0033280|response to vitamin D;GO:0042359|vitamin D metabolic process;GO:0042369|vitamin D catabolic process;","GO:0005654|nucleoplasm;GO:0005739|mitochondrion;","GO:0005506|iron ion binding;GO:0008403|25-hydroxycholecalciferol-24-hydroxylase activity;GO:0020037|heme binding;GO:0030342|1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity;GO:0070576|vitamin D 24-hydroxylase activity;GO:0070643|vitamin D 25-hydroxylase activity;","K07436","CYP24A1; vitamin D3 24-hydroxylase [EC:1.14.15.16]"]
["ENSRNOG00000017072",0,0.04151333,10,0.643304382,0.064531397,-3.953854939,0.003618725,0.003178322,"down","yes","Slc16a14","protein_coding","chr9:86112894-86137318:-","gi|564369481|ref|XP_006245450.1|",2626,0,"PREDICTED: monocarboxylate transporter 14 isoform X1 [Rattus norvegicus]","gi|672065655|ref|XM_006245388.2|",2480,0,"PREDICTED: Rattus norvegicus solute carrier family 16, member 14 (Slc16a14), transcript variant X1, mRNA","Q8K1C7",979,0,"Monocarboxylate transporter 14","AF0367",81.3,{"v":2e-15,"d":"2.00E-15"},"COG0477","pfam07690","MFS_1","Major Facilitator Superfamily.","GO:0015718|monocarboxylic acid transport;GO:0055085|transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;","GO:0008028|monocarboxylic acid transmembrane transporter activity;","K08190","SLC16A14; MFS transporter, MCT family, solute carrier family 16 (monocarboxylic acid transporters), member 14"]
["ENSRNOG00000026371",0,0.04151333,10,0.643304382,0.064531397,-3.953854939,0.003618725,0.003178322,"down","yes","Krt17","protein_coding","chr10:85178675-85183392:-","gi|47087085|ref|NP_997710.1|",1671,0,"keratin, type I cytoskeletal 17 [Rattus norvegicus]","gi|71896558|ref|NM_212545.2|",1260,0,"Rattus norvegicus keratin 17, type I (Krt17), mRNA","Q6IFU8",645,0,"Keratin, type I cytoskeletal 17",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0002009|morphogenesis of an epithelium;GO:0030307|positive regulation of cell growth;GO:0031069|hair follicle morphogenesis;GO:0031424|keratinization;GO:0045103|intermediate filament-based process;GO:0045109|intermediate filament organization;GO:0045727|positive regulation of translation;GO:0051798|positive regulation of hair follicle development;","GO:0005737|cytoplasm;GO:0005882|intermediate filament;GO:0045095|keratin filament;GO:0045111|intermediate filament cytoskeleton;GO:0071944|cell periphery;","GO:0005198|structural molecule activity;GO:0005200|structural constituent of cytoskeleton;","K07604","KRT1; type I keratin, acidic"]
["ENSRNOG00000027821",0,0.04151333,10,0.643304382,0.064531397,-3.953854939,0.003618725,0.003178322,"down","yes","Lcn9","protein_coding","chr3:8636548-8652200:+","gi|672044786|ref|XP_008759844.1|",765,{"v":2e-96,"d":"2.00E-96"},"PREDICTED: epididymal-specific lipocalin-9 isoform X1 [Rattus norvegicus]","gi|108947877|gb|DQ537496.1|",427,0,"Rattus norvegicus lipocalin 9 (Lcn9) mRNA, complete cds","Q9D267",232,{"v":2e-72,"d":"2.00E-72"},"Epididymal-specific lipocalin-9",".",".",".",".","pfam00061","Lipocalin","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.",".","GO:0005615|extracellular space;","GO:0005550|pheromone binding;GO:0036094|small molecule binding;",".","."]
["ENSRNOG00000033706",0,0.04151333,10,0.643304382,0.064531397,-3.953854939,0.003618725,0.003178322,"down","yes","Klk14","protein_coding","chr1:94131998-94137240:+","gi|293344027|ref|XP_001080394.2|",1231,{"v":7e-167,"d":"7.00E-167"},"PREDICTED: kallikrein-14 [Rattus norvegicus]","gi|672013508|ref|XM_001080394.5|",1202,0,"PREDICTED: Rattus norvegicus kallikrein related-peptidase 14 (Klk14), mRNA","Q8CGR5",442,{"v":5e-154,"d":"5.00E-154"},"Kallikrein-14","VC1200",103,{"v":1e-23,"d":"1.00E-23"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;GO:0009566|fertilization;GO:0045744|negative regulation of G protein-coupled receptor signaling pathway;GO:0045745|positive regulation of G protein-coupled receptor signaling pathway;GO:0048730|epidermis morphogenesis;GO:0070684|seminal clot liquefaction;","GO:0005615|extracellular space;GO:0030141|secretory granule;","GO:0004252|serine-type endopeptidase activity;","K09622","KLK14; kallikrein 14 [EC:3.4.21.-]"]
["ENSRNOG00000053333",0,0.04151333,10,0.643304382,0.064531397,-3.953854939,0.003618725,0.003178322,"down","yes","U6","snRNA","chr17:21277383-21277488:+","gi|686705190|ref|XP_009231420.1|",118,8e-07,"PREDICTED: actin, alpha skeletal muscle-like [Pongo abelii]","gi|937347072|ref|NG_044165.1|",60,{"v":1e-21,"d":"1.00E-21"},"Homo sapiens RNA, U6 small nuclear 1060, pseudogene (RNU6-1060P) on chromosome 6",".",".",".",".",".",".",".",".","pfam02313","Fumarate_red_D","Fumarate reductase subunit D. Fumarate reductase is a membrane-bound flavoenzyme consisting of four subunits, A-B. A and B comprise the membrane-extrinsic catalytic domain and C and D link the catalytic centres to the electron-transport chain. This family consists of the 13kD hydrophobic subunit D.",".",".",".",".","."]
["ENSRNOG00000057966",0,0.04151333,10,0.643304382,0.064531397,-3.953854939,0.003618725,0.003178322,"down","yes","Smim31","protein_coding","chr16:24604159-24640814:+","gi|148696741|gb|EDL28688.1|",307,{"v":7e-33,"d":"7.00E-33"},"mCG140493, partial [Mus musculus]","gi|672029299|ref|XR_596938.1|",449,0,"PREDICTED: Rattus norvegicus actin, cytoplasmic 2-like (LOC100910404), ncRNA",".",".",".",".",".",".",".",".","pfam10086","DUF2324","Putative membrane peptidase family (DUF2324). This domain, found in various hypothetical bacterial proteins, has no known function. This family appears to be related to the prenyl protease 2 family pfam02517, suggesting this family may be peptidases.",".","GO:0016021|integral component of membrane;GO:0030424|axon;",".",".","."]
["ENSRNOG00000058009",0,0.04151333,10,0.643304382,0.064531397,-3.953854939,0.003618725,0.003178322,"down","yes","SNORA70","snoRNA","chr11:44586288-44586425:+","gi|664730342|ref|XP_008522378.1|",120,3e-07,"PREDICTED: 60S ribosomal protein L10-like [Equus przewalskii]","gi|589968209|ref|XM_006996537.1|",118,{"v":8e-54,"d":"8.00E-54"},"PREDICTED: Peromyscus maniculatus bairdii tRNA methyltransferase 10 homolog C (S. cerevisiae) (Trmt10c), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam00777","Glyco_transf_29","Glycosyltransferase family 29 (sialyltransferase). Members of this family belong to glycosyltransferase family 29.",".",".",".",".","."]
["ENSRNOG00000062839",0,0.04151333,10,0.643304382,0.064531397,-3.953854939,0.003618725,0.003178322,"down","yes","ENSRNOG00000062839","protein_coding","chr19:29819856-29820542:-","gi|672031222|ref|XP_008772446.1|",777,{"v":1e-102,"d":"1.00E-102"},"PREDICTED: LOW QUALITY PROTEIN: AP-3 complex subunit sigma-1-like [Rattus norvegicus]","gi|672031221|ref|XM_008774224.1|",355,0,"PREDICTED: Rattus norvegicus similar to AP-3 complex subunit sigma-1 (Adapter-related protein complex 3 sigma-1 subunit) (Sigma-adaptin 3a) (AP-3 complex sigma-3A subunit) (Sigma-3A-adaptin) (LOC689488), mRNA","Q9DCR2",293,{"v":2E-100,"d":"2.00E-100"},"AP-3 complex subunit sigma-1","SPAC30D11.05",159,{"v":1e-48,"d":"1.00E-48"},"COG5030","pfam01217","Clat_adaptor_s","Clathrin adaptor complex small chain.",".",".",".",".","."]
["ENSRNOG00000065827",0,0.04151333,10,0.643304382,0.064531397,-3.953854939,0.003618725,0.003178322,"down","yes","ENSRNOG00000065827","protein_coding","chr4:23456894-23501158:-","gi|37654224|gb|AAQ96217.1|",2598,0,"LRRGT00004 [Rattus norvegicus]","gi|672048942|ref|XR_592001.1|",1668,0,"PREDICTED: Rattus norvegicus hypothetical LOC287992 (LOC287992), transcript variant X2, misc_RNA","P03385",52.4,9e-06,"Envelope glycoprotein",".",".",".",".","pfam00429","TLV_coat","ENV polyprotein (coat polyprotein).",".",".",".",".","."]
["ENSRNOG00000069543",0,0.04151333,10,0.643304382,0.064531397,-3.953854939,0.003618725,0.003178322,"down","yes","ENSRNOG00000069543","lncRNA","chr7:100988796-100995640:+","gi|149066259|gb|EDM16132.1|",165,{"v":9E-13,"d":"9.00E-13"},"KH domain containing, RNA binding, signal transduction associated 3, isoform CRA_c [Rattus norvegicus]","gi|672059363|ref|XR_593592.1|",321,{"v":5E-166,"d":"5.00E-166"},"PREDICTED: Rattus norvegicus uncharacterized LOC103692931 (LOC103692931), ncRNA",".",".",".",".",".",".",".",".","pfam10176","DUF2370","Protein of unknown function (DUF2370). This family is conserved from fungi to humans. The human member is annotated as a Golgi-associated protein-Nedd4 WW domain-binding protein but this could not be confirmed.",".",".",".",".","."]
["ENSRNOG00000071110",18,1.494479889,49,3.152191471,0.474108221,-1.076711686,0.003881728,3.387494E-3,"down","yes","ENSRNOG00000071110","lncRNA","chr12:41473664-41475204:-","gi|148701441|gb|EDL33388.1|",178,{"v":1e-12,"d":"1.00E-12"},"mCG1045525, partial [Mus musculus]","gi|354799899|gb|JN964400.1|",365,0,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Unc119b:tm1a(EUCOMM)Hmgu; transgenic",".",".",".",".",".",".",".",".","pfam15385","SARG","Specifically androgen-regulated gene protein. This family of proteins is found in eukaryotes, the function of this protein is still unknown but it is thought to be an androgen receptor. Protein expression is up-regulated in the presence of androgens, but not in the presence of glucocorticoids. SARG tends to be highly expressed in prostate tissue. Proteins in this family are typically between 340 and 587 amino acids in length. There is a conserved EETI sequence motif.",".",".",".",".","."]
["ENSRNOG00000007354",7,0.581186624,27,1.736921831,0.334607242,-1.579459424,0.003951377,0.003442169,"down","yes","Trpa1","protein_coding","chr5:4379999-4433570:+","gi|46485385|ref|NP_997491.1|",6015,0,"transient receptor potential cation channel subfamily A member 1 [Rattus norvegicus]","gi|46485384|ref|NM_207608.1|",3369,0,"Rattus norvegicus transient receptor potential cation channel, subfamily A, member 1 (Trpa1), mRNA","Q6RI86",2321,0,"Transient receptor potential cation channel subfamily A member 1","all2748",123,{"v":2e-28,"d":"2.00E-28"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0006816|calcium ion transport;GO:0006874|cellular calcium ion homeostasis;GO:0007166|cell surface receptor signaling pathway;GO:0009409|response to cold;GO:0009410|response to xenobiotic stimulus;GO:0010033|response to organic substance;GO:0014070|response to organic cyclic compound;GO:0014832|urinary bladder smooth muscle contraction;GO:0019233|sensory perception of pain;GO:0034605|cellular response to heat;GO:0035774|positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0042542|response to hydrogen peroxide;GO:0048265|response to pain;GO:0050955|thermoception;GO:0050966|detection of mechanical stimulus involved in sensory perception of pain;GO:0050968|detection of chemical stimulus involved in sensory perception of pain;GO:0051209|release of sequestered calcium ion into cytosol;GO:0051289|protein homotetramerization;GO:0070417|cellular response to cold;GO:0070588|calcium ion transmembrane transport;GO:0071244|cellular response to carbon dioxide;GO:0071310|cellular response to organic substance;GO:0071313|cellular response to caffeine;GO:0097553|calcium ion transmembrane import into cytosol;GO:0098908|regulation of neuronal action potential;GO:1903522|regulation of blood circulation;GO:1903793|positive regulation of anion transport;GO:1904058|positive regulation of sensory perception of pain;","GO:0005887|integral component of plasma membrane;GO:0016324|apical plasma membrane;GO:0030424|axon;GO:0032421|stereocilium bundle;","GO:0005216|ion channel activity;GO:0005245|voltage-gated calcium channel activity;GO:0005262|calcium channel activity;GO:0005515|protein binding;GO:0015267|channel activity;GO:0015278|calcium-release channel activity;GO:0042802|identical protein binding;GO:0097604|temperature-gated cation channel activity;GO:1990760|osmolarity-sensing cation channel activity;","K04984","TRPA1, ANKTM1; transient receptor potential cation channel subfamily A member 1"]
["ENSRNOG00000029449",7,0.581186624,27,1.736921831,0.334607242,-1.579459424,0.003951377,0.003442169,"down","yes","Ror1","protein_coding","chr5:114744304-115088155:+","gi|157822115|ref|NP_001102141.1|",4620,0,"tyrosine-protein kinase transmembrane receptor ROR1 precursor [Rattus norvegicus]","gi|157822114|ref|NM_001108671.1|",3533,0,"Rattus norvegicus receptor tyrosine kinase-like orphan receptor 1 (Ror1), mRNA","Q9Z139",1754,0,"Inactive tyrosine-protein kinase transmembrane receptor ROR1",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0006468|protein phosphorylation;GO:0007275|multicellular organism development;GO:0007605|sensory perception of sound;GO:0010976|positive regulation of neuron projection development;GO:0014002|astrocyte development;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0016055|Wnt signaling pathway;GO:0033674|positive regulation of kinase activity;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043410|positive regulation of MAPK cascade;GO:0048839|inner ear development;GO:0051092|positive regulation of NF-kappaB transcription factor activity;","GO:0001725|stress fiber;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0043235|receptor complex;GO:0043679|axon terminus;","GO:0005524|ATP binding;GO:0017147|Wnt-protein binding;GO:0042813|Wnt-activated receptor activity;","K05122","ROR1, NTRKR1; receptor tyrosine kinase-like orphan receptor 1 [EC:2.7.10.1]"]
["ENSRNOG00000016749",4,0.332106642,20,1.286608764,0.258125587,-1.953854939,0.004031846,0.00350626,"down","yes","Klhl10","protein_coding","chr10:85376442-85392720:+","gi|395826410|ref|XP_003786411.1|",3445,0,"PREDICTED: kelch-like protein 10 isoform X1 [Otolemur garnettii]","gi|48040498|ref|NM_001001510.1|",2009,0,"Rattus norvegicus kelch-like family member 10 (Klhl10), mRNA","Q6JEL3",1276,0,"Kelch-like protein 10",".",".",".",".","pfam07707","BACK","BTB And C-terminal Kelch. This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).","GO:0000902|cell morphogenesis;GO:0007286|spermatid development;GO:0008584|male gonad development;GO:0009566|fertilization;GO:0016567|protein ubiquitination;GO:0048808|male genitalia morphogenesis;GO:0048873|homeostasis of number of cells within a tissue;","GO:0005737|cytoplasm;",".","K10448","KLHL10; kelch-like protein 10"]
["ENSRNOG00000049047",4,0.332106642,20,1.286608764,0.258125587,-1.953854939,0.004031846,0.00350626,"down","yes","Rpl38","protein_coding","chr16:10182742-10182954:-","gi|327358533|gb|AEA51113.1|",277,{"v":7e-30,"d":"7.00E-30"},"60S ribosomal protein L38, partial [Oryzias melastigma]","gi|672079841|ref|XR_596381.1|",213,{"v":2e-106,"d":"2.00E-106"},"PREDICTED: Rattus norvegicus ribosomal protein L38, pseudogene 3 (Rpl38-ps3), misc_RNA","P63174",97.1,{"v":3e-26,"d":"3.00E-26"},"60S ribosomal protein L38",".",".",".",".","pfam01781","Ribosomal_L38e","Ribosomal L38e protein family.",".",".",".",".","."]
["ENSRNOG00000068325",4,0.332106642,20,1.286608764,0.258125587,-1.953854939,0.004031846,0.00350626,"down","yes","ENSRNOG00000068325","lncRNA","chr6:101245181-101246318:-","gi|82793898|ref|XP_728222.1|",243,{"v":2e-20,"d":"2.00E-20"},"hypothetical protein, partial [Plasmodium yoelii yoelii 17XNL]","gi|672020938|ref|XR_347372.2|",884,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103690066 (LOC103690066), transcript variant X1, ncRNA","P11369",98.2,{"v":6e-21,"d":"6.00E-21"},"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam08482","HrpB_C","ATP-dependent helicase C-terminal. This domain is found near the C-terminus of bacterial ATP-dependent helicases such as HrpB.",".",".",".",".","."]
["ENSRNOG00000008693",17,1.411453229,47,3.023530595,0.46682287,-1.099052854,0.004032627,0.00350626,"down","yes","Tssk3","protein_coding","chr5:141827606-141829255:-","gi|504161247|ref|XP_004591677.1|",1436,0,"PREDICTED: testis-specific serine/threonine-protein kinase 3 [Ochotona princeps]","gi|56090248|ref|NM_001007650.1|",1003,0,"Rattus norvegicus testis-specific serine kinase 3 (Tssk3), mRNA","Q9D2E1",555,0,"Testis-specific serine/threonine-protein kinase 3",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006468|protein phosphorylation;GO:0007283|spermatogenesis;GO:0035556|intracellular signal transduction;",".","GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;","K08811","TSSK, STK22; testis-specific serine kinase [EC:2.7.11.1]"]
["ENSRNOG00000015117",17,1.411453229,47,3.023530595,0.46682287,-1.099052854,0.004032627,0.00350626,"down","yes","Lrrc39","protein_coding","chr2:204516123-204535463:+","gi|157820333|ref|NP_001103107.1|",1670,0,"leucine-rich repeat-containing protein 39 [Rattus norvegicus]","gi|157820332|ref|NM_001109637.1|",2869,0,"Rattus norvegicus leucine rich repeat containing 39 (Lrrc39), mRNA","D3ZXS4",647,0,"Leucine-rich repeat-containing protein 39","alr0124_1",105,{"v":8e-23,"d":"8.00E-23"},"COG4886","pfam05206","TRM13","Methyltransferase TRM13. This is a family of eukaryotic proteins which are responsible for 2'-O-methylation of tRNA at position 4. TRM13 shows no sequence similarity to other known methyltransferases.","GO:0006470|protein dephosphorylation;GO:0007165|signal transduction;","GO:0005737|cytoplasm;GO:0031430|M band;GO:0043231|intracellular membrane-bounded organelle;","GO:0004722|protein serine/threonine phosphatase activity;",".","."]
["ENSRNOG00000057240",16,1.328426568,45,2.894869718,0.458889932,-1.12377994,0.004173336,0.003617881,"down","yes","Snord49b","snoRNA","chr10:47296946-47297016:+",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","pfam06434","Aconitase_2_N","Aconitate hydratase 2 N-terminus. This family represents the N-terminal region of several bacterial Aconitate hydratase 2 proteins and is found in conjunction with pfam00330.",".",".",".",".","."]
["ENSRNOG00000007837",8,0.664213284,29,1.865582707,0.356035292,-1.489907839,0.004215506,0.003651861,"down","yes","Acot11","protein_coding","chr5:121527435-121581538:-","gi|406035346|ref|NP_001258312.1|",3219,0,"acyl-coenzyme A thioesterase 11 [Rattus norvegicus]","gi|406035345|ref|NM_001271383.1|",2052,0,"Rattus norvegicus acyl-CoA thioesterase 11 (Acot11), mRNA","Q8VHQ9",1206,0,"Acyl-coenzyme A thioesterase 11","BH0798",92.8,{"v":1e-20,"d":"1.00E-20"},"COG1607","pfam01852","START","START domain.","GO:0006631|fatty acid metabolic process;GO:0006637|acyl-CoA metabolic process;GO:0009266|response to temperature stimulus;GO:0009409|response to cold;GO:0120163|negative regulation of cold-induced thermogenesis;","GO:0005737|cytoplasm;GO:0005759|mitochondrial matrix;GO:0005829|cytosol;","GO:0008289|lipid binding;GO:0016290|palmitoyl-CoA hydrolase activity;GO:0036042|long-chain fatty acyl-CoA binding;GO:0047617|acyl-CoA hydrolase activity;GO:0052689|carboxylic ester hydrolase activity;GO:0052816|long-chain acyl-CoA hydrolase activity;","K12417","ACOT11; acyl-CoA thioesteraes 11 [EC:3.1.2.-]"]
["ENSRNOG00000012593",9,0.747239945,31,1.994243584,0.374698432,-1.416198153,0.004394252,3.792321E-3,"down","yes","Mmel1","protein_coding","chr5:165431343-165461716:+","gi|157819215|ref|NP_001101467.1|",4134,0,"membrane metallo-endopeptidase-like 1 [Rattus norvegicus]","gi|157819214|ref|NM_001107997.1|",2806,0,"Rattus norvegicus membrane metallo-endopeptidase-like 1 (Mmel1), mRNA","P0C1T0",1584,0,"Membrane metallo-endopeptidase-like 1","MA2001",323,{"v":1e-96,"d":"1.00E-96"},"COG3590","pfam05649","Peptidase_M13_N","Peptidase family M13. M13 peptidases are well-studied proteases found in a wide range of organisms including mammals and bacteria. In mammals they participate in processes such as cardiovascular development, blood-pressure regulation, nervous control of respiration, and regulation of the function of neuropeptides in the central nervous system. In bacteria they may be used for digestion of milk.","GO:0006508|proteolysis;GO:0008150|biological_process;GO:0016485|protein processing;","GO:0005615|extracellular space;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0004175|endopeptidase activity;GO:0004222|metalloendopeptidase activity;GO:0008270|zinc ion binding;GO:0046872|metal ion binding;","K08635","MMEL1, NEP; neprilysin [EC:3.4.24.11]"]
["ENSRNOG00000064701",9,0.747239945,31,1.994243584,0.374698432,-1.416198153,0.004394252,3.792321E-3,"down","yes","Ncs1","protein_coding","chr3:14523220-14568829:+","gi|625228313|ref|XP_003515206.2|",896,{"v":8e-112,"d":"8.00E-112"},"PREDICTED: neuronal calcium sensor 1 isoform X1, partial [Cricetulus griseus]","gi|672045028|ref|XM_008761679.1|",1617,0,"PREDICTED: Rattus norvegicus neuronal calcium sensor 1 (Ncs1), transcript variant X2, mRNA","P62168",330,{"v":1e-105,"d":"1.00E-105"},"Neuronal calcium sensor 1","SPAC18B11.04",243,{"v":1E-73,"d":"1.00E-73"},"COG5126","pfam13499","EF-hand_7","EF-hand domain pair.",".",".",".",".","."]
["ENSRNOG00000029079",13,1.079346587,39,2.508887089,0.430209311,-1.216889345,0.004487583,0.003869114,"down","yes","Hspb7","protein_coding","chr5:153727588-153731266:+","gi|821034534|ref|XP_012353958.1|",794,{"v":2e-97,"d":"2.00E-97"},"PREDICTED: heat shock protein beta-7 isoform X3 [Nomascus leucogenys]","gi|158749560|ref|NM_031607.1|",1737,0,"Rattus norvegicus heat shock protein family B (small) member 7 (Hspb7), mRNA","P35385",274,{"v":2e-86,"d":"2.00E-86"},"Heat shock protein beta-7",".",".",".",".","pfam00011","HSP20","Hsp20/alpha crystallin family.","GO:0007507|heart development;GO:0009408|response to heat;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0015030|Cajal body;GO:0015629|actin cytoskeleton;GO:0016235|aggresome;","GO:0031005|filamin binding;","K09546","HSPB7; heat shock protein beta-7"]
["ENSRNOG00000018167",10,0.830266605,33,2.12290446,0.391099374,-1.354392868,0.004499568,0.003876931,"down","yes","Tmem221","protein_coding","chr16:18262052-18266967:-","gi|392333550|ref|XP_003752924.1|",582,{"v":7e-67,"d":"7.00E-67"},"PREDICTED: transmembrane protein 221 isoform X2 [Rattus norvegicus]","gi|672079940|ref|XM_002728393.4|",1908,0,"PREDICTED: Rattus norvegicus transmembrane protein 221 (Tmem221), transcript variant X2, mRNA","Q8K071",212,{"v":3e-62,"d":"3.00E-62"},"Transmembrane protein 221",".",".",".",".","pfam15038","Jiraiya","Jiraiya. Jiraiya inhibits bone morphogenetic protein (BMP) signaling during embryogenesis. The human member of this family is TMEM221.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000031773",11,0.913293266,35,2.251565336,0.405625922,-1.301778242,0.004543196,3.91136E-3,"down","yes","Cngb1","protein_coding","chr19:9726595-9791173:+","gi|149032406|gb|EDL87297.1|",3402,0,"rCG39000, isoform CRA_c [Rattus norvegicus]","gi|13929147|ref|NM_031809.1|",3840,0,"Rattus norvegicus cyclic nucleotide gated channel beta 1 (Cngb1), mRNA","Q28181",1143,0,"Cyclic nucleotide-gated cation channel beta-1",".",".",".",".","pfam00027","cNMP_binding","Cyclic nucleotide-binding domain.","GO:0001895|retina homeostasis;GO:0006812|cation transport;GO:0007601|visual perception;GO:0007602|phototransduction;GO:0007608|sensory perception of smell;GO:0010628|positive regulation of gene expression;GO:0021630|olfactory nerve maturation;GO:0033365|protein localization to organelle;GO:0035845|photoreceptor cell outer segment organization;GO:0045494|photoreceptor cell maintenance;GO:0050908|detection of light stimulus involved in visual perception;GO:0050911|detection of chemical stimulus involved in sensory perception of smell;GO:0051480|regulation of cytosolic calcium ion concentration;GO:0051899|membrane depolarization;GO:0098655|cation transmembrane transport;GO:0099105|ion channel modulating, G protein-coupled receptor signaling pathway;GO:1990834|response to odorant;","GO:0001750|photoreceptor outer segment;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0017071|intracellular cyclic nucleotide activated cation channel complex;GO:0043195|terminal bouton;GO:1902495|transmembrane transporter complex;","GO:0005221|intracellular cyclic nucleotide activated cation channel activity;GO:0005222|intracellular cAMP-activated cation channel activity;GO:0005223|intracellular cGMP-activated cation channel activity;GO:0030553|cGMP binding;GO:0043855|cyclic nucleotide-gated ion channel activity;GO:0044877|protein-containing complex binding;","K04952","CNGB1; cyclic nucleotide gated channel beta 1"]
["ENSRNOG00000066224",19,1.57750655,50,3.216521909,0.490438615,-1.02785552,0.004981137,0.004248354,"down","yes","ENSRNOG00000066224","protein_coding","chr1:61696583-61723282:+","gi|672012928|ref|XP_008772592.1|",2222,0,"PREDICTED: zinc finger protein 501-like isoform X3 [Rattus norvegicus]","gi|672012927|ref|XM_008774370.1|",2494,0,"PREDICTED: Rattus norvegicus zinc finger protein 845-like (LOC102548728), transcript variant X3, mRNA","A2VDQ7",322,{"v":3e-95,"d":"3.00E-95"},"Zinc finger protein 420",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000064936",18,1.494479889,48,3.087861033,0.483985475,-1.046964343,0.005215701,0.004431269,"down","yes","ENSRNOG00000064936","lncRNA","chr8:103583889-103588475:-",".",".",".",".","gi|672063251|ref|XR_594108.1|",2642,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102549824 (LOC102549824), transcript variant X1, ncRNA",".",".",".",".",".",".",".",".","pfam05539","Pneumo_att_G","Pneumovirinae attachment membrane glycoprotein G.",".",".",".",".","."]
["ENSRNOG00000052770",6,0.498159963,24,1.543930516,0.322656983,-1.631926844,0.005401774,0.004569926,"down","yes","U6","snRNA","chr6:14995891-14995987:-",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","pfam02460","Patched","Patched family. The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.",".",".",".",".","."]
["ENSRNOG00000054889",1,0.083026661,11,0.70763482,0.117329812,-3.091358462,0.005595724,0.004719024,"down","yes","Wdr72","protein_coding","chr8:74838318-75018229:+","gi|208973290|ref|NP_001129191.1|",5378,0,"WD repeat-containing protein 72 [Rattus norvegicus]","gi|208973289|ref|NM_001135719.1|",3133,0,"Rattus norvegicus WD repeat domain 72 (Wdr72), mRNA","D3YYM4",1946,0,"WD repeat-containing protein 72",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.","GO:0008150|biological_process;GO:0022617|extracellular matrix disassembly;GO:0070166|enamel mineralization;GO:0072659|protein localization to plasma membrane;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005768|endosome;","GO:0003674|molecular_function;","K24753","WDR72; WD repeat-containing protein 72"]
["ENSRNOG00000011044",16,1.328426568,44,2.83053928,0.469319249,-1.091358462,0.005665848,0.004773754,"down","yes","Clmn","protein_coding","chr6:123713507-123807272:-","gi|166157468|ref|NP_001100225.2|",4774,0,"calmin [Rattus norvegicus]","gi|166157467|ref|NM_001106755.2|",4069,0,"Rattus norvegicus calmin (Clmn), mRNA","Q8C5W0",1608,0,"Calmin","SPAC15A10.08",150,{"v":1e-36,"d":"1.00E-36"},"COG5069","pfam00307","CH","Calponin homology (CH) domain. The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.","GO:0007097|nuclear migration;GO:0008285|negative regulation of cell proliferation;GO:0031175|neuron projection development;","GO:0005640|nuclear outer membrane;GO:0005737|cytoplasm;GO:0016021|integral component of membrane;GO:0034993|meiotic nuclear membrane microtubule tethering complex;","GO:0051015|actin filament binding;",".","."]
["ENSRNOG00000025290",16,1.328426568,44,2.83053928,0.469319249,-1.091358462,0.005665848,0.004773754,"down","yes","AABR07038029.1","protein_coding","chrX:34713175-34858807:-","gi|392343155|ref|XP_001054480.3|",6444,0,"PREDICTED: mitogen-activated protein kinase kinase kinase 15 isoform X1 [Rattus norvegicus]","gi|672032266|ref|XM_001054480.5|",4316,0,"PREDICTED: Rattus norvegicus mitogen-activated protein kinase kinase kinase 15 (Map3k15), transcript variant X1, mRNA","A2AQW0",2442,0,"Mitogen-activated protein kinase kinase kinase 15",".",".",".",".","pfam13281","DUF4071","Domain of unknown function (DUF4071). This domain is found at the N-terminus of many serine-threonine kinase-like proteins.",".",".",".",".","."]
["ENSRNOG00000055049",16,1.328426568,44,2.83053928,0.469319249,-1.091358462,0.005665848,0.004773754,"down","yes","Aldh1a2","protein_coding","chr8:71877850-71957107:+","gi|225735575|ref|NP_446348.2|",2765,0,"retinal dehydrogenase 2 [Rattus norvegicus]","gi|225735574|ref|NM_053896.2|",2244,0,"Rattus norvegicus aldehyde dehydrogenase 1 family, member A2 (Aldh1a2), mRNA","Q63639",1069,0,"Retinal dehydrogenase 2","SPAC9E9.09c",551,0,"COG1012","pfam00171","Aldedh","Aldehyde dehydrogenase family. This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:1.2.1.3. Succinate-semialdehyde dehydrogenase EC:1.2.1.16. Lactaldehyde dehydrogenase EC:1.2.1.22. Benzaldehyde dehydrogenase EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase EC: 1.5.1.12. Acetaldehyde dehydrogenase EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase EC:1.2.1.41. This family also includes omega crystallin, an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.","GO:0001568|blood vessel development;GO:0001822|kidney development;GO:0001889|liver development;GO:0001936|regulation of endothelial cell proliferation;GO:0002138|retinoic acid biosynthetic process;GO:0003007|heart morphogenesis;GO:0007494|midgut development;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0009855|determination of bilateral symmetry;GO:0009952|anterior/posterior pattern specification;GO:0009954|proximal/distal pattern formation;GO:0010628|positive regulation of gene expression;GO:0014032|neural crest cell development;GO:0016331|morphogenesis of embryonic epithelium;GO:0021915|neural tube development;GO:0021983|pituitary gland development;GO:0030182|neuron differentiation;GO:0030324|lung development;GO:0030326|embryonic limb morphogenesis;GO:0030900|forebrain development;GO:0030902|hindbrain development;GO:0031016|pancreas development;GO:0031076|embryonic camera-type eye development;GO:0032355|response to estradiol;GO:0033189|response to vitamin A;GO:0034097|response to cytokine;GO:0035115|embryonic forelimb morphogenesis;GO:0035799|ureter maturation;GO:0042572|retinol metabolic process;GO:0042573|retinoic acid metabolic process;GO:0042574|retinal metabolic process;GO:0042904|9-cis-retinoic acid biosynthetic process;GO:0043010|camera-type eye development;GO:0043065|positive regulation of apoptotic process;GO:0048384|retinoic acid receptor signaling pathway;GO:0048566|embryonic digestive tract development;GO:0048738|cardiac muscle tissue development;GO:0051289|protein homotetramerization;GO:0060324|face development;GO:0071300|cellular response to retinoic acid;GO:0090242|retinoic acid receptor signaling pathway involved in somitogenesis;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0048471|perinuclear region of cytoplasm;","GO:0001758|retinal dehydrogenase activity;GO:0004028|3-chloroallyl aldehyde dehydrogenase activity;GO:0004029|aldehyde dehydrogenase (NAD) activity;GO:0016918|retinal binding;","K07249","ALDH1A; retinal dehydrogenase [EC:1.2.1.36]"]
["ENSRNOG00000016388",2,0.166053321,14,0.900626135,0.184375419,-2.439281766,0.005756006,0.00484461,"down","yes","Sphkap","protein_coding","chr9:84510964-84657559:-","gi|564369074|ref|XP_006245296.1|",8737,0,"PREDICTED: A-kinase anchor protein SPHKAP isoform X5 [Rattus norvegicus]","gi|672065639|ref|XM_006245234.2|",5215,0,"PREDICTED: Rattus norvegicus SPHK1 interactor, AKAP domain containing (Sphkap), transcript variant X5, mRNA","P0C6C0",3224,0,"A-kinase anchor protein SPHKAP",".",".",".",".","pfam05716","AKAP_110","A-kinase anchor protein 110 kDa (AKAP 110). This family consists of several mammalian protein kinase A anchoring protein 3 (PRKA3) or A-kinase anchor protein 110 kDa (AKAP 110) sequences. Agents that increase intracellular cAMP are potent stimulators of sperm motility. Anchoring inhibitor peptides, designed to disrupt the interaction of the cAMP-dependent protein kinase A (PKA) with A kinase-anchoring proteins (AKAPs), are potent inhibitors of sperm motility. PKA anchoring is a key biochemical mechanism controlling motility. AKAP110 shares compartments with both RI and RII isoforms of PKA and may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.",".","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0030018|Z disc;","GO:0051018|protein kinase A binding;",".","."]
["ENSRNOG00000063114",2,0.166053321,14,0.900626135,0.184375419,-2.439281766,0.005756006,0.00484461,"down","yes","ENSRNOG00000063114","lncRNA","chr1:224187736-224189816:-",".",".",".",".","gi|46240889|gb|AC118249.11|",169,{"v":1e-81,"d":"1.00E-81"},"Mus musculus chromosome 19, clone RP23-397G23, complete sequence",".",".",".",".",".",".",".",".","pfam11045","YbjM","Putative inner membrane protein of Enterobacteriaceae. This family is conserved in the Enterobacteriaceae. It is a putative inner membrane protein, named YbjM, but the function is not known.",".",".",".",".","."]
["ENSRNOG00000066805",2,0.166053321,14,0.900626135,0.184375419,-2.439281766,0.005756006,0.00484461,"down","yes","ENSRNOG00000066805","lncRNA","chrX:16297627-16300926:-","gi|148675219|gb|EDL07166.1|",171,{"v":4e-12,"d":"4.00E-12"},"mCG1028420, partial [Mus musculus]","gi|73760428|gb|AC159503.10|",169,{"v":4e-81,"d":"4.00E-81"},"Mus musculus 10 BAC RP24-293I2 (Roswell Park Cancer Institute (C57BL/6J Male) Mouse BAC Library) complete sequence",".",".",".",".",".",".",".",".","pfam09771","Tmemb_18A","Transmembrane protein 188. The function of this family of transmembrane proteins has not, as yet, been determined.",".",".",".",".","."]
["ENSRNOG00000023214",7,0.581186624,26,1.672591393,0.347476751,-1.52501164,0.005841715,0.004908994,"down","yes","Il20rb","protein_coding","chr8:100980383-101009942:-","gi|290746395|ref|NP_001166909.1|",1207,{"v":2e-158,"d":"2.00E-158"},"interleukin-20 receptor subunit beta [Rattus norvegicus]","gi|290746394|ref|NM_001173438.1|",767,0,"Rattus norvegicus interleukin 20 receptor subunit beta (Il20rb), mRNA","Q6UXL0",349,{"v":3e-113,"d":"3.00E-113"},"Interleukin-20 receptor subunit beta",".",".",".",".","pfam01108","Tissue_fac","Tissue factor. This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.","GO:0001808|negative regulation of type IV hypersensitivity;GO:0002437|inflammatory response to antigenic stimulus;GO:0002765|immune response-inhibiting signal transduction;GO:0019221|cytokine-mediated signaling pathway;GO:0032689|negative regulation of interferon-gamma production;GO:0032703|negative regulation of interleukin-2 production;GO:0032733|positive regulation of interleukin-10 production;GO:0032753|positive regulation of interleukin-4 production;GO:0042130|negative regulation of T cell proliferation;GO:0048873|homeostasis of number of cells within a tissue;GO:0050863|regulation of T cell activation;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004896|cytokine receptor activity;GO:0042015|interleukin-20 binding;","K05137","IL20RB; interleukin 20 receptor beta"]
["ENSRNOG00000016151",15,1.245399908,42,2.701878404,0.460938548,-1.117353671,5.871823E-3,0.004931702,"down","yes","Ankrd23","protein_coding","chr9:38773240-38779839:-","gi|564368071|ref|XP_006244876.1|",1366,{"v":5e-179,"d":"5.00E-179"},"PREDICTED: ankyrin repeat domain-containing protein 23 isoform X1 [Rattus norvegicus]","gi|672064892|ref|XM_006244814.2|",2250,0,"PREDICTED: Rattus norvegicus ankyrin repeat domain 23 (Ankrd23), transcript variant X1, mRNA","Q812A3",508,{"v":4e-172,"d":"4.00E-172"},"Ankyrin repeat domain-containing protein 23","TVN1399",85.9,{"v":1e-17,"d":"1.00E-17"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0006631|fatty acid metabolic process;GO:0009612|response to mechanical stimulus;GO:0035994|response to muscle stretch;GO:0060297|regulation of sarcomere organization;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0014704|intercalated disc;GO:0015629|actin cytoskeleton;GO:0030016|myofibril;GO:0031674|I band;","GO:0003674|molecular_function;GO:0031432|titin binding;","K21438","ANKRD23; ankyrin repeat domain-containing protein 23"]
["ENSRNOG00000022964",8,0.664213284,28,1.801252269,0.368750838,-1.439281766,0.006140384,5.147797E-3,"down","yes","Rnf222","protein_coding","chr10:53596751-53603300:+","gi|116089300|ref|NP_796034.2|",788,{"v":5e-95,"d":"5.00E-95"},"RING finger protein 222 [Mus musculus]","gi|672067984|ref|XM_008767846.1|",2685,0,"PREDICTED: Rattus norvegicus ring finger protein 222 (Rnf222), transcript variant X4, mRNA","Q8CEF8",308,{"v":2e-96,"d":"2.00E-96"},"RING finger protein 222",".",".",".",".","pfam13639","zf-RING_2","Ring finger domain.",".","GO:0016021|integral component of membrane;","GO:0046872|metal ion binding;",".","."]
["ENSRNOG00000051867",4,0.332106642,19,1.222278326,0.271711144,-1.879854357,0.006304793,0.00526905,"down","yes","Zfp758","protein_coding","chr1:61942116-61989490:-","gi|564296578|ref|XP_006223031.1|",3394,0,"PREDICTED: zinc finger protein 260-like [Rattus norvegicus]","gi|672070789|ref|XM_006228088.2|",2384,0,"PREDICTED: Rattus norvegicus zinc finger protein 758 (Zfp758), mRNA","A2VDQ7",596,0,"Zinc finger protein 420",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0016604|nuclear body;","GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0043565|sequence-specific DNA binding;GO:0046872|metal ion binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSRNOG00000057952",4,0.332106642,19,1.222278326,0.271711144,-1.879854357,0.006304793,0.00526905,"down","yes","Gm23130","snoRNA","chr1:21681557-21681630:+",".",".",".",".","gi|908663432|tpe|LN872617.1|",59,{"v":2e-21,"d":"2.00E-21"},"TPA: Mus musculus SNORD101 gene for small nucleolar RNA SNORD101",".",".",".",".",".",".",".",".","pfam09191","CD4-extracel","CD4, extracellular. Members of this family adopt an immunoglobulin-like beta-sandwich, with seven strands in 2 beta sheets, in a Greek key topology. They are predominantly found in the extracellular portion of CD4 proteins, where they enable interaction with major histocompatibility complex class II antigens.",".",".",".",".","."]
["ENSRNOG00000003443",9,0.747239945,30,1.929913146,0.38718838,-1.368892438,6.318911E-3,0.005280158,"down","yes","Klf1","protein_coding","chr19:23250631-23253758:-","gi|157820761|ref|NP_001100634.1|",1589,0,"Krueppel-like factor 1 [Rattus norvegicus]","gi|298890131|emb|FQ233857.1|",1346,0,"Rattus norvegicus TL0AEA60YC05 mRNA sequence","P46099",543,0,"Krueppel-like factor 1",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0001701|in utero embryonic development;GO:0001889|liver development;GO:0006338|chromatin remodeling;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0010628|positive regulation of gene expression;GO:0030218|erythrocyte differentiation;GO:0035162|embryonic hemopoiesis;GO:0043249|erythrocyte maturation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048821|erythrocyte development;GO:0060135|maternal process involved in female pregnancy;GO:1901653|cellular response to peptide;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987|proximal promoter sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0019904|protein domain specific binding;","K09204","KLF1; krueppel-like factor 1"]
["ENSRNOG00000006588",0,0.04151333,9,0.578973944,0.071701552,-3.801851845,0.006429621,0.00536006,"down","yes","Meox2","protein_coding","chr6:53856758-53917467:+","gi|795154920|ref|XP_011839342.1|",1163,{"v":1E-150,"d":"1.00E-150"},"PREDICTED: homeobox protein MOX-2 isoform X1 [Mandrillus leucophaeus]","gi|8393772|ref|NM_017149.1|",2201,0,"Rattus norvegicus mesenchyme homeobox 2 (Meox2), mRNA","P32443",447,{"v":2E-150,"d":"2.00E-150"},"Homeobox protein MOX-2",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0001525|angiogenesis;GO:0001757|somite specification;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007519|skeletal muscle tissue development;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0060021|roof of mouth development;GO:0060173|limb development;GO:0061053|somite development;GO:0090051|negative regulation of cell migration involved in sprouting angiogenesis;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0016607|nuclear speck;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09322","MEOX, MOX; homeobox protein MOX"]
["ENSRNOG00000012218",0,0.04151333,9,0.578973944,0.071701552,-3.801851845,0.006429621,0.00536006,"down","yes","Poteg","protein_coding","chr16:64488637-64670375:-","gi|672080422|ref|XP_008769552.1|",5273,0,"PREDICTED: POTE ankyrin domain family member H isoform X1 [Rattus norvegicus]","gi|672080421|ref|XM_008771330.1|",3209,0,"PREDICTED: Rattus norvegicus POTE ankyrin domain family, member G (Poteg), transcript variant X1, mRNA","Q811D2",219,{"v":1e-55,"d":"1.00E-55"},"Ankyrin repeat domain-containing protein 26","all2748",83.6,{"v":2e-15,"d":"2.00E-15"},"COG0666","pfam12001","DUF3496","Domain of unknown function (DUF3496). This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 110 amino acids in length.",".",".",".","K17299","POTE; POTE ankyrin domain family protein"]
["ENSRNOG00000031344",0,0.04151333,9,0.578973944,0.071701552,-3.801851845,0.006429621,0.00536006,"down","yes","AABR07048770.1","protein_coding","chr5:88097665-88098141:-","gi|114145756|ref|NP_001041329.1|",829,{"v":3e-111,"d":"3.00E-111"},"developmental pluripotency-associated protein 3 [Rattus norvegicus]","gi|672052968|ref|XR_592552.1|",477,0,"PREDICTED: Rattus norvegicus developmental pluripotency-associated 3, pseudogene 2 (Dppa3-ps2), misc_RNA","Q6IMK0",323,{"v":1e-112,"d":"1.00E-112"},"Developmental pluripotency-associated protein 3",".",".",".",".","pfam15549","PGC7_Stella","PGC7/Stella/Dppa3 domain. The domain belongs to a fast evolving family known only from the placental mammals. The PGC7/Stella/Dppa3 protein protects imprinted regions from demethylation post-fertilization. This suggests that it might bind methylated DNA sequences directly. The conserved core includes a postively charged helical segment and a C-terminal CXCXXC motif that is predicted to chelate a metal ion. Most placental mammals contain 3-6 paralogs of this domain family. The CXCXXC motif is also conserved in a subset of fungal MBD4-like proteins.",".",".",".",".","."]
["ENSRNOG00000051714",0,0.04151333,9,0.578973944,0.071701552,-3.801851845,0.006429621,0.00536006,"down","yes","SNORA70","snoRNA","chr4:165144932-165145065:-","gi|859922493|ref|XP_012902851.1|",111,6e-06,"PREDICTED: 60S ribosomal protein L10-like [Mustela putorius furo]","gi|908663336|tpe|LN872540.1|",119,{"v":2e-54,"d":"2.00E-54"},"TPA: Mus musculus SNORA70 (U70) gene for small nucleolar RNA SNORA70 (U70)",".",".",".",".",".",".",".",".","pfam06267","DUF1028","Family of unknown function (DUF1028). Family of bacterial and archaeal proteins with unknown function. Some members are associated with a C-terminal peptidoglycan binding domain. So perhaps this could be an enzyme involved in peptidoglycan metabolizm.",".",".",".",".","."]
["ENSRNOG00000062425",0,0.04151333,9,0.578973944,0.071701552,-3.801851845,0.006429621,0.00536006,"down","yes","ENSRNOG00000062425","protein_coding","chr9:2926288-2935264:-","gi|564310981|ref|XP_006226724.1|",900,{"v":2E-116,"d":"2.00E-116"},"PREDICTED: disks large homolog 5-like isoform X1 [Rattus norvegicus]","gi|71043739|ref|NM_001025755.1|",1243,0,"Rattus norvegicus similar to RIKEN cDNA 1700001E04 (MGC116197), mRNA",".",".",".",".",".",".",".",".","pfam04822","Takusan","Takusan. This domain is named takusan, which is a Japanese word meaning 'many'. Members of this family regulate synaptic activity.",".",".",".",".","."]
["ENSRNOG00000066049",0,0.04151333,9,0.578973944,0.071701552,-3.801851845,0.006429621,0.00536006,"down","yes","ENSRNOG00000066049","lncRNA","chr7:107854715-107856810:+","gi|149066135|gb|EDM16008.1|",154,{"v":5e-10,"d":"5.00E-10"},"rCG60114, isoform CRA_a [Rattus norvegicus]","gi|672059653|ref|XR_593605.1|",978,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102548374 (LOC102548374), transcript variant X7, ncRNA",".",".",".",".",".",".",".",".","pfam15005","IZUMO","Izumo sperm-egg fusion. Izumo is a molecule with a single immunoglobulin (Ig) domain. It is thought that Izumo bind to putative Izumo receptors on the oocyte. Izumo is not detectable on the surface of fresh sperm but becomes exposed only after an exocytotic process, the acrosome reaction, has occurred. Studies have shown that knock-out mice (Izumo-/- males) were sterile despite normal mating behaviour and ejaculation, indicating the importance of the protein in fertilization. There are cysteine residues thought to form a disulphide bridge. Izumo is a typical type I membrane glycoprotein with one immunoglobulin-like domain and a putative N-glycoside link motif (Asn 204). There is a conserved GCL sequence motif. Izumo expression has been found to be testis-specific. This family of proteins is found in eukaryotes and are typically between 193 and 305 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000066817",0,0.04151333,9,0.578973944,0.071701552,-3.801851845,0.006429621,0.00536006,"down","yes","ENSRNOG00000066817","lncRNA","chr4:153521057-153533698:-",".",".",".",".","gi|31581812|gb|AC135963.3|",90,{"v":1e-37,"d":"1.00E-37"},"Mus musculus BAC clone RP23-346N11 from chromosome 7, complete sequence",".",".",".",".",".",".",".",".","pfam15324","TALPID3","Hedgehog signalling target. TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.",".",".",".",".","."]
["ENSRNOG00000069150",0,0.04151333,9,0.578973944,0.071701552,-3.801851845,0.006429621,0.00536006,"down","yes","U1","snRNA","chr6:72227044-72227207:-","gi|927196956|ref|XP_013836555.1|",275,{"v":1E-26,"d":"1.00E-26"},"PREDICTED: inactive serine/threonine-protein kinase TEX14 [Sus scrofa]","gi|354799381|gb|JN963882.1|",164,{"v":3E-79,"d":"3.00E-79"},"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Tex14:tm1e(EUCOMM)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam02317","Octopine_DH","NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain. This group of enzymes act on the CH-NH substrate bond using NAD(+) or NADP(+) as an acceptor. The Pfam family consists mainly of octopine and nopaline dehydrogenases from Ti plasmids.",".",".",".",".","."]
["ENSRNOG00000027098",17,1.411453229,45,2.894869718,0.487570553,-1.036317099,0.007315352,0.006034721,"down","yes","Sez6l2","protein_coding","chr1:181557109-181577456:+","gi|157820407|ref|NP_001101020.1|",4296,0,"seizure 6-like protein 2 precursor [Rattus norvegicus]","gi|158138533|ref|NM_001107550.2|",4207,0,"Rattus norvegicus seizure related 6 homolog (mouse)-like 2 (Sez6l2), mRNA","Q4V9Z5",1603,0,"Seizure 6-like protein 2",".",".",".",".","pfam00431","CUB","CUB domain.","GO:0008344|adult locomotory behavior;GO:0021680|cerebellar Purkinje cell layer development;GO:0060074|synapse maturation;GO:0090036|regulation of protein kinase C signaling;","GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;GO:0043025|neuronal cell body;",".","K24363","SEZ6; seizure protein 6"]
["ENSRNOG00000001806",5,0.415133303,21,1.350939202,0.307292365,-1.702316172,0.007324912,6.041828E-3,"down","yes","Fetub","protein_coding","chr11:78082156-78095135:-","gi|564377401|ref|XP_006248611.1|",1906,0,"PREDICTED: fetuin-B isoform X1 [Rattus norvegicus]","gi|564377400|ref|XM_006248549.1|",1344,0,"PREDICTED: Rattus norvegicus fetuin B (Fetub), transcript variant X1, mRNA","Q9QX79",702,0,"Fetuin-B",".",".",".",".","pfam00031","Cystatin","Cystatin domain. Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 are related to this family but have not been included.","GO:0007338|single fertilization;GO:0007339|binding of sperm to zona pellucida;GO:0010951|negative regulation of endopeptidase activity;","GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0004866|endopeptidase inhibitor activity;GO:0004869|cysteine-type endopeptidase inhibitor activity;GO:0008191|metalloendopeptidase inhibitor activity;","K23411","FETUB; fetuin-B"]
["ENSRNOG00000022709",16,1.328426568,43,2.766208842,0.48023365,-1.058191599,7.651588E-3,0.006280494,"down","yes","AABR07046657.1","protein_coding","chr5:1451326-1453094:-","gi|564392471|ref|XP_006254406.1|",2383,0,"PREDICTED: acyl-CoA-binding domain-containing protein 5 isoform X2 [Rattus norvegicus]","gi|672018986|ref|XM_006225163.2|",1502,0,"PREDICTED: Rattus norvegicus similar to acyl-Coenzyme A binding domain containing 5 (LOC679565), mRNA","A0FKI7",915,0,"Acyl-CoA-binding domain-containing protein 5","RSc1366",62.4,{"v":9e-11,"d":"9.00E-11"},"COG4281","pfam00887","ACBP","Acyl CoA binding protein.",".",".",".",".","."]
["ENSRNOG00000002126",15,1.245399908,41,2.637547966,0.472180951,-1.082588253,0.00797543,0.006519526,"down","yes","Ncam2","protein_coding","chr11:20104925-20591984:+","gi|42821116|ref|NP_981954.1|",3844,0,"neural cell adhesion molecule 2 precursor [Rattus norvegicus]","gi|42821115|ref|NM_203409.1|",4078,0,"Rattus norvegicus neural cell adhesion molecule 2 (Ncam2), mRNA","O35136",1479,0,"Neural cell adhesion molecule 2",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0007155|cell adhesion;GO:0007413|axonal fasciculation;GO:0007608|sensory perception of smell;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016604|nuclear body;GO:0030424|axon;GO:0043005|neuron projection;","GO:0042802|identical protein binding;","K06491","NCAM, CD56; neural cell adhesion molecule"]
["ENSRNOG00000063781",15,1.245399908,41,2.637547966,0.472180951,-1.082588253,0.00797543,0.006519526,"down","yes","ENSRNOG00000063781","protein_coding","chr5:127376764-127398397:+","gi|300797222|ref|NP_001178499.1|",1849,0,"ankyrin repeat domain-containing protein 13C [Rattus norvegicus]","gi|672053518|ref|XM_008763971.1|",1927,0,"PREDICTED: Rattus norvegicus ankyrin repeat domain-containing protein 13C-like (LOC102548397), transcript variant X2, mRNA","Q3UX43",701,0,"Ankyrin repeat domain-containing protein 13C",".",".",".",".","pfam11904","GPCR_chapero_1","GPCR-chaperone. This domain, and the associated ANK family repeat pfam00023 domain, together act as a chaperone for biogenesis and folding of the DP receptor for prostaglandin D2.",".",".",".",".","."]
["ENSRNOG00000066478",3,0.249079982,16,1.029287011,0.241992738,-2.046964343,0.008013288,0.00654378,"down","yes","ENSRNOG00000066478","lncRNA","chr7:111383555-111403144:+","gi|884912773|ref|XP_013007310.1|",409,{"v":6e-56,"d":"6.00E-56"},"PREDICTED: LOW QUALITY PROTEIN: endogenous retrovirus group K member 113 Pol protein-like [Cavia porcellus]","gi|672022133|ref|XR_348114.2|",1440,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102547313 (LOC102547313), ncRNA",".",".",".",".",".",".",".",".","pfam00692","dUTPase","dUTPase. dUTPase hydrolyses dUTP to dUMP and pyrophosphate.",".",".",".",".","."]
["ENSRNOG00000023551",6,0.498159963,23,1.479600078,0.336685548,-1.570526299,0.008072204,0.006590208,"down","yes","Sp6","protein_coding","chr10:82005294-82011013:+","gi|402899442|ref|XP_003912706.1|",1761,0,"PREDICTED: transcription factor Sp6 isoform X1 [Papio anubis]","gi|157819102|ref|NM_001108833.1|",1995,0,"Rattus norvegicus Sp6 transcription factor (Sp6), mRNA","Q9ESX2",653,0,"Transcription factor Sp6",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0008284|positive regulation of cell proliferation;GO:0042481|regulation of odontogenesis;","GO:0005634|nucleus;GO:0005829|cytosol;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;","K09196","SP6; transcription factor Sp6"]
["ENSRNOG00000052173",14,1.162373247,39,2.508887089,0.463302335,-1.109974141,0.008278721,0.006743313,"down","yes","Ranbp3l","protein_coding","chr2:58058263-58113172:+","gi|564299910|ref|XP_006224097.1|",2465,0,"PREDICTED: ran-binding protein 3-like isoform X1 [Rattus norvegicus]","gi|672015484|ref|XM_006224035.2|",2866,0,"PREDICTED: Rattus norvegicus RAN binding protein 3-like (Ranbp3l), transcript variant X1, mRNA","Q6PDH4",795,0,"Ran-binding protein 3-like",".",".",".",".","pfam00638","Ran_BP1","RanBP1 domain.","GO:0045663|positive regulation of myoblast differentiation;GO:0045668|negative regulation of osteoblast differentiation;GO:0050790|regulation of catalytic activity;GO:1901706|mesenchymal cell differentiation involved in bone development;",".","GO:0046332|SMAD binding;",".","."]
["ENSRNOG00000066989",14,1.162373247,39,2.508887089,0.463302335,-1.109974141,0.008278721,0.006743313,"down","yes","ENSRNOG00000066989","lncRNA","chr19:25228881-25231042:-",".",".",".",".","gi|28372771|gb|AC124757.4|",389,0,"Mus musculus BAC clone RP23-116P5 from 8, complete sequence",".",".",".",".",".",".",".",".","pfam11032","ApoM","Apolipoprotein M (ApoM). ApoM is a 25 kDa plasma protein associated with high-density lipoproteins (HDLs). ApoM is important in the formation of pre-ss-HDL and also in increasing cholesterol efflux from macrophage foam cells. Lipoproteins consist of lipids solubilized by apolipoproteins. ApoM lacks an external amphipathic motif and is uniquely secreted to plasma without cleavage of its terminal signal peptide.",".",".",".",".","."]
["ENSRNOG00000067837",13,1.079346587,37,2.380226213,0.453463869,-1.140940491,0.008551219,0.006946274,"down","yes","ENSRNOG00000067837","lncRNA","chr16:69165481-69217498:+","gi|149036607|gb|EDL91225.1|",177,{"v":4e-12,"d":"4.00E-12"},"rCG56442 [Rattus norvegicus]","gi|32996900|gb|AC115361.5|",317,{"v":4e-163,"d":"4.00E-163"},"Mus musculus BAC clone RP24-76P12 from chromosome 8, complete sequence",".",".",".",".",".",".",".",".","pfam01603","B56","Protein phosphatase 2A regulatory B subunit (B56 family). Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolizm. The ability of this widely distributed heterotrimeric enzyme to act on a diverse array of substrates is largely controlled by the nature of its regulatory B subunit. There are multiple families of B subunits (See also pfam01240), this family is called the B56 family.",".",".",".",".","."]
["ENSRNOG00000021381",7,0.581186624,25,1.608260955,0.361375822,-1.468428112,0.00857976,0.006964565,"down","yes","Ccdc68","protein_coding","chr18:63541896-63584119:+","gi|149064570|gb|EDM14773.1|",1572,0,"similar to CTCL tumor antigen se57-1 (predicted), isoform CRA_b [Rattus norvegicus]","gi|755561085|ref|XM_006526071.2|",919,0,"PREDICTED: Mus musculus coiled-coil domain containing 68 (Ccdc68), transcript variant X2, mRNA","Q8BVC4",496,{"v":3e-172,"d":"3.00E-172"},"Coiled-coil domain-containing protein 68",".",".",".",".","pfam15619","Lebercilin","Ciliary protein causing Leber congenital amaurosis disease. Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.","GO:0008104|protein localization;GO:0034454|microtubule anchoring at centrosome;GO:0035556|intracellular signal transduction;","GO:0005622|intracellular;GO:0005814|centriole;GO:0120103|centriolar subdistal appendage;",".","K25398","CCDC68; coiled-coil domain containing protein 68"]
["ENSRNOG00000062702",7,0.581186624,25,1.608260955,0.361375822,-1.468428112,0.00857976,0.006964565,"down","yes","ENSRNOG00000062702","lncRNA","chr20:12420808-12423028:+",".",".",".",".","gi|672031625|ref|XR_599383.1|",520,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103694402 (LOC103694402), ncRNA",".",".",".",".",".",".",".",".","pfam01500","Keratin_B2","Keratin, high sulfur B2 protein. High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.",".",".",".",".","."]
["ENSRNOG00000014256",12,0.996319926,35,2.251565336,0.442501006,-1.17624736,0.008780152,0.007104683,"down","yes","Foxa3","protein_coding","chr1:78662431-78672155:-","gi|3461895|dbj|BAA32535.1|",1291,{"v":5e-173,"d":"5.00E-173"},"hepatocyte nuclear factor 3 gamma [Rattus norvegicus]","gi|3461894|dbj|AB017044.1|",1419,0,"Rattus norvegicus gene for hepatocyte nuclear factor 3 gamma, partial cds","P32183",501,{"v":7e-174,"d":"7.00E-174"},"Hepatocyte nuclear factor 3-gamma","ECU11g1330",94,{"v":1e-20,"d":"1.00E-20"},"COG5025","pfam00250","Fork_head","Fork head domain.","GO:0001678|cellular glucose homeostasis;GO:0006325|chromatin organization;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007283|spermatogenesis;GO:0008285|negative regulation of cell proliferation;GO:0009267|cellular response to starvation;GO:0009653|anatomical structure morphogenesis;GO:0030154|cell differentiation;GO:0031667|response to nutrient levels;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0061484|hematopoietic stem cell homeostasis;GO:0070368|positive regulation of hepatocyte differentiation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0015629|actin cytoskeleton;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0019904|protein domain specific binding;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K08038","FOXA3, HNF3G; forkhead box protein A3, hepatocyte nuclear factor 3-gamma"]
["ENSRNOG00000014691",12,0.996319926,35,2.251565336,0.442501006,-1.17624736,0.008780152,0.007104683,"down","yes","Ric3","protein_coding","chr1:163032158-163086519:-","gi|169234822|ref|NP_001108517.1|",1534,0,"protein RIC-3 isoform 1 [Rattus norvegicus]","gi|672038084|ref|XR_590390.1|",3953,0,"PREDICTED: Rattus norvegicus RIC3 acetylcholine receptor chaperone (Ric3), transcript variant X1, misc_RNA","Q8BPM6",549,0,"Protein RIC-3",".",".",".",".","pfam15361","RIC3","Resistance to inhibitors of cholinesterase homologue 3. RIC3 is a protein associated with nicotinic acetylcholine receptors (nAChRs), neurotransmitter-gated ion channels expressed at the neuromuscular junction and within the central and peripheral nervous systems. It can enhance functional expression of multiple nAChR subtypes. RIC3 promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface.","GO:0006457|protein folding;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007271|synaptic transmission, cholinergic;GO:0034394|protein localization to cell surface;GO:0034622|cellular protein-containing complex assembly;GO:2000010|positive regulation of protein localization to cell surface;","GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043231|intracellular membrane-bounded organelle;GO:0045202|synapse;","GO:0033130|acetylcholine receptor binding;GO:0044183|protein binding involved in protein folding;",".","."]
["ENSRNOG00000020054",12,0.996319926,35,2.251565336,0.442501006,-1.17624736,0.008780152,0.007104683,"down","yes","ENSRNOG00000020054","protein_coding","chr18:29181052-29183804:+","gi|293354902|ref|XP_001055818.2|",4047,0,"PREDICTED: protocadherin beta-7 isoform X2 [Rattus norvegicus]","gi|672083180|ref|XM_001055818.5|",2753,0,"PREDICTED: Rattus norvegicus similar to protocadherin beta 16 (LOC690826), transcript variant X2, mRNA","Q9Y5E2",1187,0,"Protocadherin beta-7",".",".",".",".","pfam08266","Cadherin_2","Cadherin-like. This cadherin domain is usually the most N-terminal copy of the domain.","GO:0007155|cell adhesion;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;","GO:0005887|integral component of plasma membrane;","GO:0005509|calcium ion binding;","K16494","PCDHB; protocadherin beta"]
["ENSRNOG00000021087",12,0.996319926,35,2.251565336,0.442501006,-1.17624736,0.008780152,0.007104683,"down","yes","Lgi4","protein_coding","chr1:86295074-86304874:+","gi|41054852|ref|NP_955793.1|",2732,0,"leucine-rich repeat LGI family member 4 precursor [Rattus norvegicus]","gi|41054851|ref|NM_199499.1|",2533,0,"Rattus norvegicus leucine-rich repeat LGI family, member 4 (Lgi4), mRNA","Q8K1S1",1030,0,"Leucine-rich repeat LGI family member 4",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.","GO:0008344|adult locomotory behavior;GO:0014009|glial cell proliferation;GO:0014044|Schwann cell development;GO:0021782|glial cell development;GO:0022011|myelination in peripheral nervous system;GO:0031641|regulation of myelination;GO:0042063|gliogenesis;GO:0042551|neuron maturation;GO:0042552|myelination;","GO:0005615|extracellular space;",".","K25430","LGI4; leucine-rich repeat LGI family member 4"]
["ENSRNOG00000066068",12,0.996319926,35,2.251565336,0.442501006,-1.17624736,0.008780152,0.007104683,"down","yes","Senp18","protein_coding","chr4:161065389-161067875:-","gi|50657410|ref|NP_001002834.1|",2563,0,"Sumo1/sentrin/SMT3 specific peptidase 18 [Rattus norvegicus]","gi|672051168|ref|XR_592289.1|",1732,0,"PREDICTED: Rattus norvegicus Sumo1/sentrin/SMT3 specific peptidase 18-like (LOC100362532), misc_RNA","Q5R7K7",398,{"v":3e-126,"d":"3.00E-126"},"Sentrin-specific protease 2","SPBC19G7.09",162,{"v":3e-41,"d":"3.00E-41"},"COG5160","pfam02902","Peptidase_C48","Ulp1 protease family, C-terminal catalytic domain. This domain contains the catalytic triad Cys-His-Asn.",".",".",".",".","."]
["ENSRNOG00000055429",8,0.664213284,27,1.736921831,0.382408277,-1.386814346,0.008886187,0.007175047,"down","yes","Snord4a","snoRNA","chr10:63077419-63077489:-",".",".",".",".","gi|908663764|tpe|LN872933.1|",53,{"v":4e-18,"d":"4.00E-18"},"TPA: Mus musculus snoZ17 gene for small nucleolar RNA snoZ17",".",".",".",".",".",".",".",".","pfam06330","TRI5","Trichodiene synthase (TRI5). This family consists of several fungal trichodiene synthase proteins (EC:4.2.3.6). TRI5 encodes the enzyme trichodiene synthase, which has been shown to catalyse the first step in the trichothecene pathways of Fusarium and Trichothecium species.",".",".",".",".","."]
["ENSRNOG00000062741",8,0.664213284,27,1.736921831,0.382408277,-1.386814346,0.008886187,0.007175047,"down","yes","Ldhal6b","protein_coding","chr1:45991991-45999272:-","gi|34328538|ref|NP_899163.1|",2021,0,"L-lactate dehydrogenase A-like 6B [Rattus norvegicus]","gi|34328537|ref|NM_183334.1|",1409,0,"Rattus norvegicus lactate dehydrogenase A-like 6B (Ldhal6b), mRNA","Q9BYZ2",598,0,"L-lactate dehydrogenase A-like 6B","CAC0267",266,{"v":6e-80,"d":"6.00E-80"},"COG0039","pfam00056","Ldh_1_N","lactate/malate dehydrogenase, NAD binding domain. L-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate. The enzyme participates in the citric acid cycle. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes. N-terminus (this family) is a Rossmann NAD-binding fold. C-terminus is an unusual alpha+beta fold.",".",".",".",".","."]
["ENSRNOG00000003705",11,0.913293266,33,2.12290446,0.430209311,-1.216889345,0.008949701,0.00721995,"down","yes","Bmx","protein_coding","chrX:30227251-30289993:+","gi|157824055|ref|NP_001102486.1|",3384,0,"cytoplasmic tyrosine-protein kinase BMX [Rattus norvegicus]","gi|157824054|ref|NM_001109016.1|",2984,0,"Rattus norvegicus BMX non-receptor tyrosine kinase (Bmx), mRNA","P97504",1246,0,"Cytoplasmic tyrosine-protein kinase BMX",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0002250|adaptive immune response;GO:0007165|signal transduction;GO:0035556|intracellular signal transduction;GO:0038083|peptidyl-tyrosine autophosphorylation;GO:0046777|protein autophosphorylation;GO:0050853|B cell receptor signaling pathway;","GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0032587|ruffle membrane;","GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0005524|ATP binding;GO:0046872|metal ion binding;","K08896","BMX, ETK; cytoplasmic tyrosine-protein kinase BMX [EC:2.7.10.2]"]
["ENSRNOG00000021513",11,0.913293266,33,2.12290446,0.430209311,-1.216889345,0.008949701,0.00721995,"down","yes","Rtn4rl2","protein_coding","chr3:69955169-69971488:-","gi|31077112|ref|NP_852045.1|",1905,0,"reticulon-4 receptor-like 2 precursor [Rattus norvegicus]","gi|880857448|ref|XM_005065082.2|",1392,0,"PREDICTED: Mesocricetus auratus reticulon 4 receptor-like 2 (Rtn4rl2), transcript variant X1, mRNA","Q80WD1",738,0,"Reticulon-4 receptor-like 2","SPy1798",72,{"v":3e-12,"d":"3.00E-12"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0007166|cell surface receptor signaling pathway;GO:0010977|negative regulation of neuron projection development;GO:0022038|corpus callosum development;","GO:0005615|extracellular space;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0030424|axon;GO:0030425|dendrite;GO:0031012|extracellular matrix;GO:0043005|neuron projection;GO:0043204|perikaryon;GO:0045121|membrane raft;GO:0046658|anchored component of plasma membrane;","GO:0005515|protein binding;GO:0038023|signaling receptor activity;","K16661","RTN4RL2, NGR2; reticulon-4 receptor-like 2"]
["ENSRNOG00000064373",11,0.913293266,33,2.12290446,0.430209311,-1.216889345,0.008949701,0.00721995,"down","yes","NEWGENE_1309147","protein_coding","chr1:78880862-78913056:+","gi|148691179|gb|EDL23126.1|",633,{"v":1e-74,"d":"1.00E-74"},"optic atrophy 3 (human), isoform CRA_b [Mus musculus]","gi|755478440|ref|XM_006544143.2|",775,0,"PREDICTED: Mus musculus optic atrophy 3 protein-like (LOC102637572), mRNA","Q9H6K4",170,{"v":1e-47,"d":"1.00E-47"},"Optic atrophy 3 protein",".",".",".",".","pfam07047","OPA3","Optic atrophy 3 protein (OPA3). This family consists of several optic atrophy 3 (OPA3) proteins. OPA3 deficiency causes type III 3-methylglutaconic aciduria (MGA) in humans. This disease manifests with early bilateral optic atrophy, spasticity, extrapyramidal dysfunction, ataxia, and cognitive deficits, but normal longevity.",".",".",".",".","."]
["ENSRNOG00000070919",11,0.913293266,33,2.12290446,0.430209311,-1.216889345,0.008949701,0.00721995,"down","yes","Foxc1","protein_coding","chr17:32633142-32634803:-","gi|403310668|ref|NP_599165.1|",1625,0,"forkhead box protein C1 [Rattus norvegicus]","gi|403310667|ref|NM_134338.1|",1659,0,"Rattus norvegicus forkhead box C1 (Foxc1), mRNA","Q61572",621,0,"Forkhead box protein C1","SPBC4C3.05",99.4,{"v":5e-21,"d":"5.00E-21"},"COG5025","pfam00250","Fork_head","Fork head domain.",".",".",".",".","."]
["ENSRNOG00000019716",9,0.747239945,29,1.865582707,0.400539704,-1.319982838,0.009028698,0.007275417,"down","yes","Ntf3","protein_coding","chr4:158914957-158984596:-","gi|399498548|ref|NP_112335.3|",1427,0,"neurotrophin-3 isoform 1 [Rattus norvegicus]","gi|672051086|ref|XM_008763294.1|",1372,0,"PREDICTED: Rattus norvegicus neurotrophin 3 (Ntf3), transcript variant X1, mRNA","P18280",540,0,"Neurotrophin-3",".",".",".",".","pfam00243","NGF","Nerve growth factor family.","GO:0002092|positive regulation of receptor internalization;GO:0007165|signal transduction;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007274|neuromuscular synaptic transmission;GO:0007399|nervous system development;GO:0007403|glial cell fate determination;GO:0007411|axon guidance;GO:0007420|brain development;GO:0007422|peripheral nervous system development;GO:0007613|memory;GO:0008284|positive regulation of cell proliferation;GO:0008544|epidermis development;GO:0021675|nerve development;GO:0030335|positive regulation of cell migration;GO:0032148|activation of protein kinase B activity;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0038180|nerve growth factor signaling pathway;GO:0042490|mechanoreceptor differentiation;GO:0042552|myelination;GO:0042981|regulation of apoptotic process;GO:0043406|positive regulation of MAP kinase activity;GO:0043523|regulation of neuron apoptotic process;GO:0043524|negative regulation of neuron apoptotic process;GO:0045664|regulation of neuron differentiation;GO:0045687|positive regulation of glial cell differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048484|enteric nervous system development;GO:0048666|neuron development;GO:0048699|generation of neurons;GO:0048812|neuron projection morphogenesis;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050732|negative regulation of peptidyl-tyrosine phosphorylation;GO:0050804|modulation of chemical synaptic transmission;GO:0050918|positive chemotaxis;GO:0050930|induction of positive chemotaxis;GO:0051145|smooth muscle cell differentiation;GO:0090630|activation of GTPase activity;GO:2000251|positive regulation of actin cytoskeleton reorganization;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0008021|synaptic vesicle;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0031410|cytoplasmic vesicle;","GO:0005163|nerve growth factor receptor binding;GO:0005165|neurotrophin receptor binding;GO:0008083|growth factor activity;GO:0042056|chemoattractant activity;GO:0048406|nerve growth factor binding;","K04356","NTF3; neurotrophin 3"]
["ENSRNOG00000029029",9,0.747239945,29,1.865582707,0.400539704,-1.319982838,0.009028698,0.007275417,"down","yes","Cxadrl1","protein_coding","chr8:99565421-99590972:-","gi|672063050|ref|XP_008764761.1|",2073,0,"PREDICTED: coxsackie virus and adenovirus receptor-like 1 isoform X1 [Rattus norvegicus]","gi|672063049|ref|XM_008766539.1|",1633,0,"PREDICTED: Rattus norvegicus coxsackie virus and adenovirus receptor-like 1 (Cxadrl1), transcript variant X1, mRNA","Q5R764",192,{"v":9e-54,"d":"9.00E-54"},"Coxsackievirus and adenovirus receptor homolog",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000009332",10,0.830266605,31,1.994243584,0.416331592,-1.264195059,0.00904043,0.007279366,"down","yes","Rec114","protein_coding","chr8:59063352-59149887:-","gi|564363936|ref|XP_006243219.1|",1361,0,"PREDICTED: meiotic recombination protein REC114 isoform X1 [Rattus norvegicus]","gi|672061886|ref|XM_006243157.2|",984,0,"PREDICTED: Rattus norvegicus REC114 meiotic recombination protein (Rec114), transcript variant X1, mRNA","Q9CWH4",442,{"v":8e-155,"d":"8.00E-155"},"Meiotic recombination protein REC114",".",".",".",".","pfam15165","REC114-like","Meiotic recombination protein REC114-like. REC114-like members are necessary for meiotic DNA double-strand break formation. It functions in conjunction with Mei4. This family of proteins is found in eukaryotes. Proteins in this family are typically between 43 and 259 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000012591",10,0.830266605,31,1.994243584,0.416331592,-1.264195059,0.00904043,0.007279366,"down","yes","Pkd2l1","protein_coding","chr1:243032913-243070031:-","gi|672040343|ref|XP_008758621.1|",3781,0,"PREDICTED: polycystic kidney disease 2-like 1 protein isoform X1 [Rattus norvegicus]","gi|672040342|ref|XM_008760399.1|",3174,0,"PREDICTED: Rattus norvegicus polycystic kidney disease 2-like 1 (Pkd2l1), transcript variant X1, mRNA","A2A259",1321,0,"Polycystic kidney disease 2-like 1 protein",".",".",".",".","pfam08016","PKD_channel","Polycystin cation channel. This family contains the cation channel region of PKD1 and PKD2 proteins.","GO:0001581|detection of chemical stimulus involved in sensory perception of sour taste;GO:0006812|cation transport;GO:0007224|smoothened signaling pathway;GO:0009415|response to water;GO:0035725|sodium ion transmembrane transport;GO:0050912|detection of chemical stimulus involved in sensory perception of taste;GO:0050915|sensory perception of sour taste;GO:0050982|detection of mechanical stimulus;GO:0051262|protein tetramerization;GO:0051289|protein homotetramerization;GO:0070588|calcium ion transmembrane transport;GO:0071467|cellular response to pH;GO:0071468|cellular response to acidic pH;GO:0071805|potassium ion transmembrane transport;GO:0098662|inorganic cation transmembrane transport;","GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0031410|cytoplasmic vesicle;GO:0034703|cation channel complex;GO:0034704|calcium channel complex;GO:0043231|intracellular membrane-bounded organelle;GO:0043235|receptor complex;GO:0060170|ciliary membrane;GO:0097730|non-motile cilium;","GO:0005227|calcium activated cation channel activity;GO:0005261|cation channel activity;GO:0005262|calcium channel activity;GO:0005272|sodium channel activity;GO:0005509|calcium ion binding;GO:0008092|cytoskeletal protein binding;GO:0008324|cation transmembrane transporter activity;GO:0015269|calcium-activated potassium channel activity;GO:0033040|sour taste receptor activity;GO:0042802|identical protein binding;GO:0051371|muscle alpha-actinin binding;GO:0051393|alpha-actinin binding;","K04990","PKD2L1; polycystin 2L1"]
["ENSRNOG00000046848",10,0.830266605,31,1.994243584,0.416331592,-1.264195059,0.00904043,0.007279366,"down","yes","PCOLCE2","protein_coding","chr8:96193461-96251114:+","gi|189083717|ref|NP_001121112.1|",1949,0,"procollagen C-endopeptidase enhancer 2 precursor [Rattus norvegicus]","gi|189083716|ref|NM_001127640.1|",1824,0,"Rattus norvegicus procollagen C-endopeptidase enhancer 2 (PCOLCE2), mRNA","Q8R4W6",744,0,"Procollagen C-endopeptidase enhancer 2",".",".",".",".","pfam00431","CUB","CUB domain.","GO:0010952|positive regulation of peptidase activity;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0005576|extracellular region;","GO:0005518|collagen binding;GO:0008201|heparin binding;GO:0016504|peptidase activator activity;","K24361","PCOLCE; procollagen C-endopeptidase enhancer"]
["ENSRNOG00000051819",10,0.830266605,31,1.994243584,0.416331592,-1.264195059,0.00904043,0.007279366,"down","yes","Sdr42e1","protein_coding","chr19:45715399-45727901:-","gi|404312655|ref|NP_001258198.1|",1922,0,"short-chain dehydrogenase/reductase family 42E member 1 [Rattus norvegicus]","gi|404312654|ref|NM_001271269.1|",2536,0,"Rattus norvegicus short chain dehydrogenase/reductase family 42E, member 1 (Sdr42e1), mRNA","Q9D665",659,0,"Short-chain dehydrogenase/reductase family 42E member 1","ML1942",140,{"v":6e-35,"d":"6.00E-35"},"COG0451","pfam01073","3Beta_HSD","3-beta hydroxysteroid dehydrogenase/isomerase family. The enzyme 3 beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase (3 beta-HSD) catalyses the oxidation and isomerization of 5-ene-3 beta-hydroxypregnene and 5-ene-hydroxyandrostene steroid precursors into the corresponding 4-ene-ketosteroids necessary for the formation of all classes of steroid hormones.","GO:0006694|steroid biosynthetic process;","GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;","GO:0003854|3-beta-hydroxy-delta5-steroid dehydrogenase activity;GO:0016616|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;",".","."]
["ENSRNOG00000070093",10,0.830266605,31,1.994243584,0.416331592,-1.264195059,0.00904043,0.007279366,"down","yes","ENSRNOG00000070093","lncRNA","chr14:78048312-78055698:-",".",".",".",".","gi|40841710|gb|AC094950.6|",469,0,"Rattus norvegicus 14 BAC CH230-6H12 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam07509","DUF1523","Protein of unknown function (DUF1523).",".",".",".",".","."]
["ENSRNOG00000003585",2,0.166053321,13,0.836295696,0.198558144,-2.332366562,0.009545669,0.00762664,"down","yes","ENSRNOG00000003585","protein_coding","chrX:12788698-13030175:-","gi|672086988|ref|XP_008771291.1|",3023,0,"PREDICTED: synaptotagmin-like protein 5 isoform X1 [Rattus norvegicus]","gi|672086987|ref|XM_008773069.1|",2194,0,"PREDICTED: Rattus norvegicus synaptotagmin-like 5 (Sytl5), transcript variant X1, mRNA","Q812E4",1167,0,"Synaptotagmin-like protein 5",".",".",".",".","pfam00168","C2","C2 domain.","GO:0006886|intracellular protein transport;GO:0006887|exocytosis;","GO:0005886|plasma membrane;GO:0070382|exocytic vesicle;","GO:0005543|phospholipid binding;GO:0031267|small GTPase binding;GO:0042043|neurexin family protein binding;GO:0046872|metal ion binding;","K17598","SYTL; synaptotagmin-like protein"]
["ENSRNOG00000006144",2,0.166053321,13,0.836295696,0.198558144,-2.332366562,0.009545669,0.00762664,"down","yes","Cntn3","protein_coding","chr4:134842266-135125613:-","gi|9506949|ref|NP_062202.1|",5256,0,"contactin-3 precursor [Rattus norvegicus]","gi|402745061|ref|NM_019329.2|",4084,0,"Rattus norvegicus contactin 3 (Cntn3), mRNA","Q62682",2029,0,"Contactin-3",".",".",".",".","pfam00041","fn3","Fibronectin type III domain.","GO:0007399|nervous system development;GO:0098609|cell-cell adhesion;","GO:0043005|neuron projection;GO:0046658|anchored component of plasma membrane;",".","K06761","CNTN3; contactin 3"]
["ENSRNOG00000008988",2,0.166053321,13,0.836295696,0.198558144,-2.332366562,0.009545669,0.00762664,"down","yes","Cyp2d2","protein_coding","chr7:113935138-113939209:-","gi|117242|sp|P10634.2|CP2DQ_RAT",2503,0,"RecName: Full=Cytochrome P450 2D26; AltName: Full=CYPIID26; AltName: Full=Cytochrome P450-CMF2; AltName: Full=Cytochrome P450-DB2; AltName: Full=Debrisoquine 4-hydroxylase","gi|6978746|ref|NM_012730.1|",1668,0,"Rattus norvegicus cytochrome P450, family 2, subfamily d, polypeptide 2 (Cyp2d2), mRNA","P10634",973,0,"Cytochrome P450 2D26","alr1450",81.3,{"v":2e-15,"d":"2.00E-15"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0006082|organic acid metabolic process;GO:0006805|xenobiotic metabolic process;GO:0007565|female pregnancy;GO:0009410|response to xenobiotic stimulus;GO:0019369|arachidonic acid metabolic process;GO:0042178|xenobiotic catabolic process;","GO:0005737|cytoplasm;GO:0005789|endoplasmic reticulum membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0004497|monooxygenase activity;GO:0005506|iron ion binding;GO:0008395|steroid hydroxylase activity;GO:0016712|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0020037|heme binding;GO:0070330|aromatase activity;","K07414","CYP2D; cytochrome P450 family 2 subfamily D [EC:1.14.14.1]"]
["ENSRNOG00000010063",2,0.166053321,13,0.836295696,0.198558144,-2.332366562,0.009545669,0.00762664,"down","yes","Htr2a","protein_coding","chr15:49950804-50020928:+","gi|8393583|ref|NP_058950.1|",2439,0,"5-hydroxytryptamine receptor 2A [Rattus norvegicus]","gi|204672|gb|M64867.1|RATHTR2",3590,0,"Rat serotonin receptor mRNA","P14842",944,0,"5-hydroxytryptamine receptor 2A",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001659|temperature homeostasis;GO:0006874|cellular calcium ion homeostasis;GO:0007187|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007202|activation of phospholipase C activity;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007208|phospholipase C-activating serotonin receptor signaling pathway;GO:0007268|chemical synaptic transmission;GO:0007568|aging;GO:0007613|memory;GO:0008219|cell death;GO:0008284|positive regulation of cell proliferation;GO:0009410|response to xenobiotic stimulus;GO:0010513|positive regulation of phosphatidylinositol biosynthetic process;GO:0014059|regulation of dopamine secretion;GO:0014065|phosphatidylinositol 3-kinase signaling;GO:0014824|artery smooth muscle contraction;GO:0014832|urinary bladder smooth muscle contraction;GO:0019233|sensory perception of pain;GO:0030431|sleep;GO:0033674|positive regulation of kinase activity;GO:0043267|negative regulation of potassium ion transport;GO:0043406|positive regulation of MAP kinase activity;GO:0044380|protein localization to cytoskeleton;GO:0045600|positive regulation of fat cell differentiation;GO:0045821|positive regulation of glycolytic process;GO:0045907|positive regulation of vasoconstriction;GO:0048148|behavioral response to cocaine;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050965|detection of temperature stimulus involved in sensory perception of pain;GO:0050966|detection of mechanical stimulus involved in sensory perception of pain;GO:0051209|release of sequestered calcium ion into cytosol;GO:0051967|negative regulation of synaptic transmission, glutamatergic;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0098664|G protein-coupled serotonin receptor signaling pathway;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005901|caveola;GO:0030424|axon;GO:0030425|dendrite;GO:0031410|cytoplasmic vesicle;GO:0043025|neuronal cell body;GO:0043198|dendritic shaft;GO:0070852|cell body fiber;GO:0098666|G protein-coupled serotonin receptor complex;GO:0098978|glutamatergic synapse;GO:0099055|integral component of postsynaptic membrane;GO:0099056|integral component of presynaptic membrane;","GO:0001587|Gq/11-coupled serotonin receptor activity;GO:0004993|G protein-coupled serotonin receptor activity;GO:0005515|protein binding;GO:0030594|neurotransmitter receptor activity;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;GO:0051378|serotonin binding;GO:0071886|1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding;","K04157","HTR2; 5-hydroxytryptamine receptor 2"]
["ENSRNOG00000013042",2,0.166053321,13,0.836295696,0.198558144,-2.332366562,0.009545669,0.00762664,"down","yes","Htr1b","protein_coding","chr8:82517360-82534549:-","gi|11560016|ref|NP_071561.1|",1960,0,"5-hydroxytryptamine receptor 1B [Rattus norvegicus]","gi|202542|gb|M89954.1|RAT5HT1BR",1545,0,"Rattus norvegicus 5-HT1B serotonin receptor gene, complete cds","P28564",759,0,"5-hydroxytryptamine receptor 1B",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0002031|G protein-coupled receptor internalization;GO:0007187|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007193|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007198|adenylate cyclase-inhibiting serotonin receptor signaling pathway;GO:0007205|protein kinase C-activating G protein-coupled receptor signaling pathway;GO:0007268|chemical synaptic transmission;GO:0007631|feeding behavior;GO:0009636|response to toxic substance;GO:0014053|negative regulation of gamma-aminobutyric acid secretion;GO:0014059|regulation of dopamine secretion;GO:0014063|negative regulation of serotonin secretion;GO:0032229|negative regulation of synaptic transmission, GABAergic;GO:0042220|response to cocaine;GO:0042310|vasoconstriction;GO:0042756|drinking behavior;GO:0045471|response to ethanol;GO:0046849|bone remodeling;GO:0050795|regulation of behavior;GO:0051385|response to mineralocorticoid;GO:0051967|negative regulation of synaptic transmission, glutamatergic;GO:0071312|cellular response to alkaloid;GO:0071466|cellular response to xenobiotic stimulus;GO:0071502|cellular response to temperature stimulus;GO:0099171|presynaptic modulation of chemical synaptic transmission;GO:0099509|regulation of presynaptic cytosolic calcium ion concentration;GO:1904707|positive regulation of vascular smooth muscle cell proliferation;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0030425|dendrite;GO:0044305|calyx of Held;GO:0098666|G protein-coupled serotonin receptor complex;GO:0099056|integral component of presynaptic membrane;GO:0099154|serotonergic synapse;","GO:0004993|G protein-coupled serotonin receptor activity;GO:0030594|neurotransmitter receptor activity;GO:0051378|serotonin binding;GO:0099626|voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels;GO:1901363|heterocyclic compound binding;","K04153","HTR1; 5-hydroxytryptamine receptor 1"]
["ENSRNOG00000013535",2,0.166053321,13,0.836295696,0.198558144,-2.332366562,0.009545669,0.00762664,"down","yes","Cdh6","protein_coding","chr2:62079137-62225228:-","gi|149027277|gb|EDL82944.1|",4100,0,"rCG23692 [Rattus norvegicus]","gi|25453399|ref|NM_012927.1|",3519,0,"Rattus norvegicus cadherin 6 (Cdh6), mRNA","P97326",1569,0,"Cadherin-6",".",".",".",".","pfam01049","Cadherin_C","Cadherin cytoplasmic region. Cadherins are vital in cell-cell adhesion during tissue differentiation. Cadherins are linked to the cytoskeleton by catenins. Catenins bind to the cytoplasmic tail of the cadherin. Cadherins cluster to form foci of homophilic binding units. A key determinant to the strength of the binding that it is mediated by cadherins is the juxtamembrane region of the cadherin. This region induces clustering and also binds to the protein p120ctn.","GO:0000902|cell morphogenesis;GO:0007043|cell-cell junction assembly;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007219|Notch signaling pathway;GO:0007275|multicellular organism development;GO:0008585|female gonad development;GO:0016339|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0034332|adherens junction organization;GO:0098742|cell-cell adhesion via plasma-membrane adhesion molecules;","GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005912|adherens junction;GO:0016021|integral component of membrane;GO:0016342|catenin complex;GO:0030054|cell junction;","GO:0005509|calcium ion binding;GO:0045296|cadherin binding;","K06798","CDH6; cadherin 6, type 2, K-cadherin"]
["ENSRNOG00000016953",2,0.166053321,13,0.836295696,0.198558144,-2.332366562,0.009545669,0.00762664,"down","yes","Chst4","protein_coding","chr19:37991417-38003608:-","gi|157818131|ref|NP_001100897.1|",2020,0,"carbohydrate sulfotransferase 4 [Rattus norvegicus]","gi|672084859|ref|XM_006255587.2|",4310,0,"PREDICTED: Rattus norvegicus carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 (Chst4), transcript variant X2, mRNA","Q9R1I1",714,0,"Carbohydrate sulfotransferase 4",".",".",".",".","pfam00685","Sulfotransfer_1","Sulfotransferase domain.","GO:0005975|carbohydrate metabolic process;GO:0006044|N-acetylglucosamine metabolic process;GO:0006477|protein sulfation;GO:0006790|sulfur compound metabolic process;GO:0050901|leukocyte tethering or rolling;GO:1903238|positive regulation of leukocyte tethering or rolling;","GO:0000139|Golgi membrane;GO:0005802|trans-Golgi network;","GO:0001517|N-acetylglucosamine 6-O-sulfotransferase activity;","K04746","CHST4; carbohydrate 6-sulfotransferase 4 [EC:2.8.2.-]"]
["ENSRNOG00000018853",2,0.166053321,13,0.836295696,0.198558144,-2.332366562,0.009545669,0.00762664,"down","yes","Slc28a3","protein_coding","chr17:6062549-6114038:+","gi|672080833|ref|XP_008769644.1|",3530,0,"PREDICTED: solute carrier family 28 member 3 isoform X1 [Rattus norvegicus]","gi|672080832|ref|XM_008771422.1|",2470,0,"PREDICTED: Rattus norvegicus solute carrier family 28 (concentrative nucleoside transporter), member 3 (Slc28a3), transcript variant X1, mRNA","Q8VIH3",1335,0,"Solute carrier family 28 member 3","all0378",306,{"v":3e-92,"d":"3.00E-92"},"COG1972","pfam07662","Nucleos_tra2_C","Na+ dependent nucleoside transporter C-terminus. This family consists of nucleoside transport proteins. Members include a purine-specific Na+-nucleoside cotransporter localized to the bile canalicular membrane and a Na+-dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine, which also transports the anti-viral nucleoside analogues AZT and ddC. This alignment covers the C-terminus of this family of transporters.","GO:0001895|retina homeostasis;GO:0015855|pyrimidine nucleobase transport;GO:0015860|purine nucleoside transmembrane transport;GO:0015862|uridine transport;GO:0015864|pyrimidine nucleoside transport;GO:0035725|sodium ion transmembrane transport;GO:0072531|pyrimidine-containing compound transmembrane transport;GO:1901642|nucleoside transmembrane transport;GO:1904823|purine nucleobase transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0031526|brush border membrane;","GO:0005337|nucleoside transmembrane transporter activity;GO:0005415|nucleoside:sodium symporter activity;GO:0015213|uridine transmembrane transporter activity;GO:0015293|symporter activity;GO:0015389|pyrimidine- and adenine-specific:sodium symporter activity;GO:0015390|purine-specific nucleoside:sodium symporter activity;","K11536","SLC28A; pyrimidine nucleoside transport protein"]
["ENSRNOG00000022957",2,0.166053321,13,0.836295696,0.198558144,-2.332366562,0.009545669,0.00762664,"down","yes","Ctxn3","protein_coding","chr18:50930235-50940641:+","gi|197927416|ref|NP_001128168.1|",329,{"v":1e-33,"d":"1.00E-33"},"cortexin-3 [Rattus norvegicus]","gi|197927415|ref|NM_001134696.1|",1476,0,"Rattus norvegicus cortexin 3 (Ctxn3), mRNA","Q8BXZ0",131,{"v":4E-35,"d":"4.00E-35"},"Cortexin-3",".",".",".",".","pfam11057","Cortexin","Cortexin of kidney. In the middle of cortexin protein there is a single membrane-spanning domain which indicates that this protein may be a membrane protein involved in intracellular or extracellular signalling of the kidney or brain, since it is expressed specifically in the kidneys and brain only. The protein is highly conserved among species. Cortexin is also thought to be important to neurons of both the developing and adult cerebral cortex.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000063238",2,0.166053321,13,0.836295696,0.198558144,-2.332366562,0.009545669,0.00762664,"down","yes","ENSRNOG00000063238","lncRNA","chr2:209823763-209826790:-",".",".",".",".","gi|672016260|ref|XR_599962.1|",1021,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102555482 (LOC102555482), ncRNA",".",".",".",".",".",".",".",".","pfam10521","DUF2454","Protein of unknown function (DUF2454). A Schizosaccharomyces pombe member of this family is known to interact with Tel2. Tel2 is a component of the TOR complexes.",".",".",".",".","."]
["ENSRNOG00000069579",2,0.166053321,13,0.836295696,0.198558144,-2.332366562,0.009545669,0.00762664,"down","yes","C1qtnf4","protein_coding","chr3:76857735-76874139:+","gi|157820195|ref|NP_001101215.1|",1568,0,"complement C1q tumor necrosis factor-related protein 4 precursor [Rattus norvegicus]","gi|197246042|gb|BC168928.1|",1370,0,"Rattus norvegicus C1q and tumor necrosis factor related protein 4, mRNA (cDNA clone MGC:189221 IMAGE:8368551), complete cds","Q8R066",592,0,"Complement C1q tumor necrosis factor-related protein 4",".",".",".",".","pfam00386","C1q","C1q domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.",".",".",".",".","."]
["ENSRNOG00000069740",2,0.166053321,13,0.836295696,0.198558144,-2.332366562,0.009545669,0.00762664,"down","yes","ENSRNOG00000069740","lncRNA","chr5:149255275-149283843:-","gi|149024333|gb|EDL80830.1|",203,{"v":6e-17,"d":"6.00E-17"},"rCG31004 [Rattus norvegicus]","gi|672054547|ref|XM_008764267.1|",201,{"v":6e-99,"d":"6.00E-99"},"PREDICTED: Rattus norvegicus zinc finger and BTB domain containing 40 (Zbtb40), transcript variant X5, mRNA",".",".",".",".",".",".",".",".","pfam14964","DUF4507","Domain of unknown function (DUF4507). This family of proteins is found in eukaryotes. Proteins in this family are typically between 346 and 434 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000071100",2,0.166053321,13,0.836295696,0.198558144,-2.332366562,0.009545669,0.00762664,"down","yes","ENSRNOG00000071100","protein_coding","chr6:129666394-129667403:-","gi|406855466|pdb|3J1T|A",337,{"v":2e-37,"d":"2.00E-37"},"Chain A, High Affinity Dynein Microtubule Binding Domain - Tubulin Complex","gi|402527|dbj|D13896.1|RATCDHC",200,{"v":6e-99,"d":"6.00E-99"},"Rattus norvegicus mRNA for cytoplasmic dynein heavy chain, complete cds","Q9JHU4",133,{"v":7e-35,"d":"7.00E-35"},"Cytoplasmic dynein 1 heavy chain 1","SPAC1093.06c",76.3,{"v":1e-15,"d":"1.00E-15"},"COG5245","pfam12777","MT","Microtubule-binding stalk of dynein motor. the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.",".",".",".",".","."]
["ENSRNOG00000000384",1,0.083026661,10,0.643304382,0.129062793,-2.953854939,0.009737708,0.007758743,"down","yes","Atoh7","protein_coding","chr20:25530826-25531275:-","gi|281427231|ref|NP_001163953.1|",557,{"v":3e-70,"d":"3.00E-70"},"protein atonal homolog 7 [Rattus norvegicus]","gi|281427230|ref|NM_001170482.1|",450,0,"Rattus norvegicus atonal bHLH transcription factor 7 (Atoh7), mRNA","Q9Z2E5",211,{"v":8e-69,"d":"8.00E-69"},"Protein atonal homolog 7",".",".",".",".","pfam00010","HLH","Helix-loop-helix DNA-binding domain.","GO:0003407|neural retina development;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007623|circadian rhythm;GO:0008150|biological_process;GO:0009649|entrainment of circadian clock;GO:0021554|optic nerve development;GO:0030182|neuron differentiation;GO:0043153|entrainment of circadian clock by photoperiod;","GO:0005575|cellular_component;GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0046983|protein dimerization activity;GO:1990837|sequence-specific double-stranded DNA binding;","K09083","ATOH1_7; atonal protein 1/7"]
["ENSRNOG00000013222",1,0.083026661,10,0.643304382,0.129062793,-2.953854939,0.009737708,0.007758743,"down","yes","Cd207","protein_coding","chr4:116155212-116161518:-","gi|392340083|ref|XP_002726471.2|",1794,0,"PREDICTED: C-type lectin domain family 4 member K [Rattus norvegicus]","gi|672018474|ref|XM_002726425.4|",1469,0,"PREDICTED: Rattus norvegicus CD207 molecule, langerin (Cd207), mRNA","Q8VBX4",613,0,"C-type lectin domain family 4 member K",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0051607|defense response to virus;","GO:0016021|integral component of membrane;","GO:0030246|carbohydrate binding;","K06561","CD207; CD207 antigen"]
["ENSRNOG00000023493",1,0.083026661,10,0.643304382,0.129062793,-2.953854939,0.009737708,0.007758743,"down","yes","Creb3l4","protein_coding","chr2:175690335-175695932:-","gi|672042937|ref|XP_008759369.1|",1594,0,"PREDICTED: cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2 [Rattus norvegicus]","gi|672042935|ref|XM_006232627.2|",1389,0,"PREDICTED: Rattus norvegicus cAMP responsive element binding protein 3-like 4 (Creb3l4), transcript variant X1, mRNA","Q5UEM7",614,0,"Cyclic AMP-responsive element-binding protein 3-like protein 4",".",".",".",".","pfam00170","bZIP_1","bZIP transcription factor. The Pfam entry includes the basic region and the leucine zipper region.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0007283|spermatogenesis;GO:0008150|biological_process;GO:0030968|endoplasmic reticulum unfolded protein response;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005739|mitochondrion;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;GO:0031965|nuclear membrane;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0035497|cAMP response element binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09048","CREB3; cyclic AMP-responsive element-binding protein 3"]
["ENSRNOG00000029591",1,0.083026661,10,0.643304382,0.129062793,-2.953854939,0.009737708,0.007758743,"down","yes","Pkdrej","protein_coding","chr7:116909094-116915468:-","gi|198442901|ref|NP_001128338.1|",10759,0,"polycystic kidney disease and receptor for egg jelly-related protein precursor [Rattus norvegicus]","gi|198442900|ref|NM_001134866.1|",6375,0,"Rattus norvegicus polycystin (PKD) family receptor for egg jelly (Pkdrej), mRNA","Q9Z0T6",3396,0,"Polycystic kidney disease and receptor for egg jelly-related protein",".",".",".",".","pfam08016","PKD_channel","Polycystin cation channel. This family contains the cation channel region of PKD1 and PKD2 proteins.","GO:0050982|detection of mechanical stimulus;GO:0060046|regulation of acrosome reaction;GO:0070588|calcium ion transmembrane transport;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0005262|calcium channel activity;GO:0005509|calcium ion binding;","K19921","PKDREJ; polycystic kidney disease and receptor for egg jelly-related protein"]
["ENSRNOG00000033983",1,0.083026661,10,0.643304382,0.129062793,-2.953854939,0.009737708,0.007758743,"down","yes","Sohlh1","protein_coding","chr3:8663318-8667388:-","gi|300797768|ref|NP_001178781.1|",1622,0,"spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1 [Rattus norvegicus]","gi|300797767|ref|NM_001191852.1|",1074,0,"Rattus norvegicus spermatogenesis and oogenesis specific basic helix-loop-helix 1 (Sohlh1), mRNA","Q6IUP1",551,0,"Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1",".",".",".",".","pfam03154","Atrophin-1","Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.","GO:0001541|ovarian follicle development;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007283|spermatogenesis;GO:0009994|oocyte differentiation;GO:0010468|regulation of gene expression;GO:0030154|cell differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048477|oogenesis;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0046982|protein heterodimerization activity;","K22495","SOHLH1; spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1"]
["ENSRNOG00000035642",1,0.083026661,10,0.643304382,0.129062793,-2.953854939,0.009737708,0.007758743,"down","yes","Mirlet7i","miRNA","chr7:58642480-58642571:-",".",".",".",".","gi|927130315|ref|XM_013997682.1|",92,{"v":1e-39,"d":"1.00E-39"},"PREDICTED: Sus scrofa translation initiation factor IF-2-like (LOC106510317), mRNA",".",".",".",".",".",".",".",".","pfam12675","DUF3795","Protein of unknown function (DUF3795). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 99 and 171 amino acids in length. This protein is likely to be zinc binding given the conserved cysteines.","GO:0007569|cell aging;GO:0009617|response to bacterium;GO:0060291|long-term synaptic potentiation;GO:0071230|cellular response to amino acid stimulus;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0016442|RISC complex;",".","K16980","MIRLET7; microRNA let-7"]
["ENSRNOG00000052948",1,0.083026661,10,0.643304382,0.129062793,-2.953854939,0.009737708,0.007758743,"down","yes","AABR07049134.4","lncRNA","chr5:103365187-103372237:-","gi|564305767|ref|XP_006225482.1|",1011,{"v":2e-126,"d":"2.00E-126"},"PREDICTED: uncharacterized protein LOC102556773 [Rattus norvegicus]","gi|71057062|emb|CR937053.2|",1305,0,"Rattus norvegicus chromosome 1 BAC CH230-476F3, complete sequence",".",".",".",".",".",".",".",".","pfam11864","DUF3384","Domain of unknown function (DUF3384). This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is typically between 422 to 486 amino acids in length. This domain is found associated with pfam02145.",".",".",".",".","."]
["ENSRNOG00000059833",1,0.083026661,10,0.643304382,0.129062793,-2.953854939,0.009737708,0.007758743,"down","yes","AABR07073270.1","snoRNA","chr7:834295-834439:-",".",".",".",".","gi|908663415|tpe|LN872606.1|",95,{"v":5e-41,"d":"5.00E-41"},"TPA: Mus musculus SNORA79 (ACA65) gene for small nucleolar RNA SNORA79 (ACA65)",".",".",".",".",".",".",".",".","pfam01081","Aldolase","KDPG and KHG aldolase. This family includes the following members: 4-hydroxy-2-oxoglutarate aldolase (KHG-aldolase) Phospho-2-dehydro-3-deoxygluconate aldolase (KDPG-aldolase)",".",".",".",".","."]
["ENSRNOG00000065876",1,0.083026661,10,0.643304382,0.129062793,-2.953854939,0.009737708,0.007758743,"down","yes","ENSRNOG00000065876","protein_coding","chr8:3488606-3573974:+","gi|37654232|gb|AAQ96221.1|",887,0,"LRRGT00008 [Rattus norvegicus]","gi|388240401|dbj|AP012441.1|",1382,0,"Rattus norvegicus DNA, BAC clone: RNB1-108K09, strain: F344/Stm, complete sequence","P11369",341,{"v":3e-94,"d":"3.00E-94"},"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam02994","Transposase_22","L1 transposable element.",".",".",".",".","."]
["ENSRNOG00000070965",1,0.083026661,10,0.643304382,0.129062793,-2.953854939,0.009737708,0.007758743,"down","yes","ENSRNOG00000070965","lncRNA","chr1:7396108-7401985:-","gi|759113103|ref|XP_011356048.1|",122,{"v":4e-12,"d":"4.00E-12"},"PREDICTED: LOW QUALITY PROTEIN: endogenous retrovirus group K member 18 Pol protein-like [Pteropus vampyrus]","gi|256985238|gb|AC118412.6|",651,0,"Rattus norvegicus CH230-221E17 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P31623",42.7,5e-09,"Gag-Pro-Pol polyprotein",".",".",".",".","pfam10322","7TM_GPCR_Sru","Serpentine type 7TM GPCR chemoreceptor Sru. Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sru is a member of the Srg superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.",".",".",".",".","."]
["ENSRNOG00000037798",17,1.411453229,44,2.83053928,0.498651702,-1.003895621,0.009775557,0.007783081,"down","yes","Erich4","protein_coding","chr1:81123556-81125296:-","gi|157822377|ref|NP_001102923.1|",633,{"v":3E-79,"d":"3.00E-79"},"glutamate-rich protein 4 [Rattus norvegicus]","gi|157822376|ref|NM_001109453.1|",937,0,"Rattus norvegicus glutamate-rich 4 (Erich4), mRNA",".",".",".",".",".",".",".",".","pfam15039","DUF4530","Domain of unknown function (DUF4530). This family of proteins is found in eukaryotes. Proteins in this family are typically around 140 amino acids in length. The human member of this family is C19orf69.",".",".",".",".","."]
["ENSRNOG00000020084",4,0.332106642,18,1.157947887,0.286806208,-1.801851845,0.009794463,0.007793282,"down","yes","Pcdhb5","protein_coding","chr18:29028382-29053259:+","gi|167736396|ref|NP_001108074.1|",3823,0,"protocadherin beta-4 [Rattus norvegicus]","gi|86440007|gb|AC096374.7|",2552,0,"Rattus norvegicus BAC CH230-17K7 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q5DRD0",1152,0,"Protocadherin beta-4",".",".",".",".","pfam08266","Cadherin_2","Cadherin-like. This cadherin domain is usually the most N-terminal copy of the domain.","GO:0007155|cell adhesion;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005887|integral component of plasma membrane;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;","K16494","PCDHB; protocadherin beta"]
["ENSRNOG00000048145",4,0.332106642,18,1.157947887,0.286806208,-1.801851845,0.009794463,0.007793282,"down","yes","Sstr1","protein_coding","chr6:75832530-75836802:+","gi|6981584|ref|NP_036851.1|",1856,0,"somatostatin receptor type 1 [Rattus norvegicus]","gi|451770400|ref|NM_012719.2|",3906,0,"Rattus norvegicus somatostatin receptor 1 (Sstr1), mRNA","P28646",719,0,"Somatostatin receptor type 1",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0007215|glutamate receptor signaling pathway;GO:0007218|neuropeptide signaling pathway;GO:0007283|spermatogenesis;GO:0021549|cerebellum development;GO:0030217|T cell differentiation;GO:0030900|forebrain development;GO:0038170|somatostatin signaling pathway;GO:0042594|response to starvation;GO:0071392|cellular response to estradiol stimulus;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0043005|neuron projection;","GO:0004930|G protein-coupled receptor activity;GO:0004994|somatostatin receptor activity;GO:0042277|peptide binding;GO:0042923|neuropeptide binding;","K04217","SSTR1; somatostatin receptor 1"]
["ENSRNOG00000015682",5,0.415133303,20,1.286608764,0.322656983,-1.631926844,0.011096447,0.008704678,"down","yes","Kel","protein_coding","chr4:70568243-70585631:-","gi|300798081|ref|NP_001178540.1|",3626,0,"kell blood group glycoprotein [Rattus norvegicus]","gi|672049507|ref|XM_006236377.2|",2456,0,"PREDICTED: Rattus norvegicus Kell blood group, metallo-endopeptidase (Kel), transcript variant X1, mRNA","Q9EQF2",1257,0,"Kell blood group glycoprotein homolog","MA2001",208,{"v":2e-56,"d":"2.00E-56"},"COG3590","pfam05649","Peptidase_M13_N","Peptidase family M13. M13 peptidases are well-studied proteases found in a wide range of organisms including mammals and bacteria. In mammals they participate in processes such as cardiovascular development, blood-pressure regulation, nervous control of respiration, and regulation of the function of neuropeptides in the central nervous system. In bacteria they may be used for digestion of milk.","GO:0006874|cellular calcium ion homeostasis;GO:0008361|regulation of cell size;GO:0010961|cellular magnesium ion homeostasis;GO:0016485|protein processing;GO:0031133|regulation of axon diameter;GO:0042552|myelination;GO:0048741|skeletal muscle fiber development;GO:1901380|negative regulation of potassium ion transmembrane transport;","GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0004222|metalloendopeptidase activity;GO:0008237|metallopeptidase activity;GO:0046872|metal ion binding;","K06577","KEL, CD238; Kell blood group glycoprotein [EC:3.4.24.-]"]
["ENSRNOG00000002753",14,1.162373247,38,2.444556651,0.475494502,-1.072499435,0.011250381,0.008813539,"down","yes","Adam11","protein_coding","chr10:87724234-87741562:+","gi|564374356|ref|XP_006247442.1|",3783,0,"PREDICTED: disintegrin and metalloproteinase domain-containing protein 11 isoform X2 [Rattus norvegicus]","gi|672068832|ref|XM_006247380.2|",3110,0,"PREDICTED: Rattus norvegicus ADAM metallopeptidase domain 11 (Adam11), transcript variant X2, mRNA","Q9R1V4",1440,0,"Disintegrin and metalloproteinase domain-containing protein 11",".",".",".",".","pfam01421","Reprolysin","Reprolysin (M12B) family zinc metalloprotease. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as human ADAM8 and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.","GO:0006508|proteolysis;GO:0007229|integrin-mediated signaling pathway;","GO:0016021|integral component of membrane;","GO:0004222|metalloendopeptidase activity;","K16067","ADAM11; disintegrin and metalloproteinase domain-containing protein 11 [EC:3.4.24.-]"]
["ENSRNOG00000003251",0,0.04151333,8,0.514643505,0.080664246,-3.631926844,0.011481418,0.008964877,"down","yes","B3galt2","protein_coding","chr13:55389406-55398419:+","gi|157823603|ref|NP_001102962.1|",2296,0,"beta-1,3-galactosyltransferase 2 [Rattus norvegicus]","gi|157823602|ref|NM_001109492.1|",4463,0,"Rattus norvegicus Beta-1,3-galactosyltransferase 2 (B3galt2), mRNA","O43825",860,0,"Beta-1,3-galactosyltransferase 2",".",".",".",".","pfam01762","Galactosyl_T","Galactosyltransferase. This family includes the galactosyltransferases UDP-galactose:2-acetamido-2-deoxy-D-glucose3beta-galactosyltransferase and UDP-Gal:beta-GlcNAc beta 1,3-galactosyltranferase. Specific galactosyltransferases transfer galactose to GlcNAc terminal chains in the synthesis of the lacto-series oligosaccharides types 1 and 2.","GO:0006486|protein glycosylation;GO:0006682|galactosylceramide biosynthetic process;GO:0009312|oligosaccharide biosynthetic process;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0008194|UDP-glycosyltransferase activity;GO:0008499|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity;GO:0016757|transferase activity, transferring glycosyl groups;","K07820","B3GALT2; beta-1,3-galactosyltransferase 2 [EC:2.4.1.86]"]
["ENSRNOG00000013768",0,0.04151333,8,0.514643505,0.080664246,-3.631926844,0.011481418,0.008964877,"down","yes","Defb1","protein_coding","chr16:70298863-70313604:-","gi|13929150|ref|NP_113998.1|",360,{"v":8e-42,"d":"8.00E-42"},"beta-defensin 1 precursor [Rattus norvegicus]","gi|13929149|ref|NM_031810.1|",392,0,"Rattus norvegicus defensin beta 1 (Defb1), mRNA","O89117",143,{"v":3E-43,"d":"3.00E-43"},"Beta-defensin 1",".",".",".",".","pfam00711","Defensin_beta","Beta defensin. The beta defensins are antimicrobial peptides implicated in the resistance of epithelial surfaces to microbial colonisation.","GO:0002227|innate immune response in mucosa;GO:0002526|acute inflammatory response;GO:0009617|response to bacterium;GO:0019731|antibacterial humoral response;GO:0019933|cAMP-mediated signaling;GO:0031640|killing of cells of other organism;GO:0033574|response to testosterone;GO:0035584|calcium-mediated signaling using intracellular calcium source;GO:0042742|defense response to bacterium;GO:0045087|innate immune response;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:0060474|positive regulation of flagellated sperm motility involved in capacitation;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;","GO:0005615|extracellular space;GO:0019898|extrinsic component of membrane;GO:0097225|sperm midpiece;GO:1990742|microvesicle;","GO:0003674|molecular_function;GO:0003690|double-stranded DNA binding;GO:0031731|CCR6 chemokine receptor binding;GO:0042802|identical protein binding;","K23125","DEFB1; beta-defensin 1"]
["ENSRNOG00000015086",0,0.04151333,8,0.514643505,0.080664246,-3.631926844,0.011481418,0.008964877,"down","yes","Plin1","protein_coding","chr1:133664892-133676828:-","gi|815890870|ref|NP_001295074.1|",2444,0,"perilipin-1 [Rattus norvegicus]","gi|815890869|ref|NM_001308145.1|",2025,0,"Rattus norvegicus perilipin 1 (Plin1), mRNA","P43884",927,0,"Perilipin-1",".",".",".",".","pfam03036","Perilipin","Perilipin family. The perilipin family includes lipid droplet-associated protein (perilipin) and adipose differentiation-related protein (adipophilin).","GO:0006629|lipid metabolic process;GO:0008150|biological_process;GO:0016042|lipid catabolic process;GO:0050995|negative regulation of lipid catabolic process;GO:0070417|cellular response to cold;","GO:0005783|endoplasmic reticulum;GO:0005811|lipid droplet;GO:0005829|cytosol;GO:0071944|cell periphery;","GO:0003674|molecular_function;","K08768","PLIN1; perilipin-1"]
["ENSRNOG00000035516",0,0.04151333,8,0.514643505,0.080664246,-3.631926844,0.011481418,0.008964877,"down","yes","Mir132","miRNA","chr10:60023696-60023796:+","gi|635086817|ref|XP_008008006.1|",159,{"v":2E-12,"d":"2.00E-12"},"PREDICTED: transcription initiation factor TFIID subunit 4-like, partial [Chlorocebus sabaeus]","gi|731442366|ref|NR_129072.1|",101,{"v":1e-44,"d":"1.00E-44"},"Eptesicus fuscus microRNA mir-132 (MIR132), microRNA",".",".",".",".",".",".",".",".","pfam11456","DUF3019","Protein of unknown function (DUF3019). This is a bacterial family of uncharacterized proteins.","GO:0007569|cell aging;GO:0014041|regulation of neuron maturation;GO:0050773|regulation of dendrite development;GO:0060291|long-term synaptic potentiation;GO:0070482|response to oxygen levels;GO:0071241|cellular response to inorganic substance;GO:1904322|cellular response to forskolin;","GO:0014069|postsynaptic density;",".",".","."]
["ENSRNOG00000043061",0,0.04151333,8,0.514643505,0.080664246,-3.631926844,0.011481418,0.008964877,"down","yes","Siah3","protein_coding","chr15:50770871-50834487:+","gi|300798222|ref|NP_001178047.1|",1304,{"v":4e-178,"d":"4.00E-178"},"seven in absentia homolog 3 [Rattus norvegicus]","gi|300798221|ref|NM_001191118.1|",807,0,"Rattus norvegicus siah E3 ubiquitin protein ligase family member 3 (Siah3), mRNA","Q8IW03",437,{"v":2e-152,"d":"2.00E-152"},"Seven in absentia homolog 3",".",".",".",".","pfam03145","Sina","Seven in absentia protein family. The seven in absentia (sina) gene was first identified in Drosophila. The Drosophila Sina protein is essential for the determination of the R7 pathway in photoreceptor cell development: the loss of functional Sina results in the transformation of the R7 precursor cell to a non- neuronal cell type. The Sina protein contains an N-terminal RING finger domain pfam00097. Through this domain, Sina binds E2 ubiquitin-conjugating enzymes (UbcD1) Sina also interacts with Tramtrack (TTK88) via PHYL. Tramtrack is a transcriptional repressor that blocks photoreceptor determination, while PHYL down-regulates the activity of TTK88. In turn, the activity of PHYL requires the activation of the Sevenless receptor tyrosine kinase, a process essential for R7 determination. It is thought that thus Sina targets TTK88 for degradation, therefore promoting the R7 pathway. Murine and human homologues of Sina have also been identified. The human homologue Siah-1 also binds E2 enzymes (UbcH5) and through a series of physical interactions, targets beta-catenin for ubiquitin degradation. Siah-1 expression is enhanced by p53, itself promoted by DNA damage. Thus this pathway links DNA damage to beta-catenin degradation. Sina proteins, therefore, physically interact with a variety of proteins. The N-terminal RING finger domain that binds ubiquitin conjugating enzymes is described in pfam00097, and does not form part of the alignment for this family. The remainder C-terminal part is involved in interactions with other proteins, and is included in this alignment. In addition to the Drosophila protein and mammalian homologues, whose similarity was noted previously, this family also includes putative homologues from Caenorhabditis elegans, Arabidopsis thaliana.","GO:0016567|protein ubiquitination;GO:0031647|regulation of protein stability;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:1903215|negative regulation of protein targeting to mitochondrion;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005739|mitochondrion;","GO:0031624|ubiquitin conjugating enzyme binding;GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;","K22256","SIAH3; seven in absentia homolog 3"]
["ENSRNOG00000057127",0,0.04151333,8,0.514643505,0.080664246,-3.631926844,0.011481418,0.008964877,"down","yes","Zg16b","protein_coding","chr10:12979020-12983572:-","gi|672066959|ref|XP_008765811.1|",859,{"v":2e-111,"d":"2.00E-111"},"PREDICTED: uncharacterized protein LOC363551 isoform X1 [Rattus norvegicus]","gi|672066958|ref|XM_008767589.1|",1049,0,"PREDICTED: Rattus norvegicus similar to Prostatic spermine-binding protein precursor (SBP) (RGD1562673), transcript variant X1, mRNA","P08723",219,{"v":3e-67,"d":"3.00E-67"},"Prostatic spermine-binding protein",".",".",".",".","pfam01419","Jacalin","Jacalin-like lectin domain. Proteins containing this domain are lectins. It is found in 1 to 6 copies in these proteins. The domain is also found in the animal prostatic spermine-binding protein.","GO:0001895|retina homeostasis;",".",".",".","."]
["ENSRNOG00000063491",0,0.04151333,8,0.514643505,0.080664246,-3.631926844,0.011481418,0.008964877,"down","yes","ENSRNOG00000063491","protein_coding","chr16:35225583-35226806:+","gi|62132952|gb|AAH92212.1|",591,{"v":4e-72,"d":"4.00E-72"},"Lonp1 protein, partial [Mus musculus]","gi|19173765|ref|NM_133404.1|",339,{"v":4E-176,"d":"4.00E-176"},"Rattus norvegicus lon peptidase 1, mitochondrial (Lonp1), mRNA","Q924S5",237,{"v":7E-72,"d":"7.00E-72"},"Lon protease homolog, mitochondrial","CT344",141,{"v":3e-38,"d":"3.00E-38"},"COG0466","pfam05362","Lon_C","Lon protease (S16) C-terminal proteolytic domain. The Lon serine proteases must hydrolyse ATP to degrade protein substrates. In Escherichia coli, these proteases are involved in turnover of intracellular proteins, including abnormal proteins following heat-shock. The active site for protease activity resides in a C-terminal domain. The Lon proteases are classified as family S16 in Merops.",".",".",".",".","."]
["ENSRNOG00000064382",0,0.04151333,8,0.514643505,0.080664246,-3.631926844,0.011481418,0.008964877,"down","yes","ENSRNOG00000064382","lncRNA","chr5:47653383-47654905:-","gi|344240604|gb|EGV96707.1|",152,3E-9,"hypothetical protein I79_017196 [Cricetulus griseus]","gi|354781541|gb|JN946042.1|",210,{"v":8e-104,"d":"8.00E-104"},"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Pnrc1:tm1e(EUCOMM)Hmgu; transgenic",".",".",".",".",".",".",".",".","pfam13347","MFS_2","MFS/sugar transport protein. This family is part of the major facilitator superfamily of membrane transport proteins.",".",".",".",".","."]
["ENSRNOG00000065831",0,0.04151333,8,0.514643505,0.080664246,-3.631926844,0.011481418,0.008964877,"down","yes","Olr162","protein_coding","chr1:158954795-158958503:+","gi|47576529|ref|NP_001000950.1|",1430,0,"olfactory receptor Olr162 [Rattus norvegicus]","gi|90855788|gb|AC128039.4|",1753,0,"Rattus norvegicus BAC CH230-394A24 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q8NGI1",442,{"v":5e-148,"d":"5.00E-148"},"Putative olfactory receptor 56B2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.",".",".",".",".","."]
["ENSRNOG00000067408",0,0.04151333,8,0.514643505,0.080664246,-3.631926844,0.011481418,0.008964877,"down","yes","ENSRNOG00000067408","lncRNA","chr8:34684180-34715465:+","gi|111813|pir||S21346",152,4e-08,"probable pol polyprotein-related protein 2 - rat","gi|14389324|gb|AC087775.2|",248,{"v":1e-124,"d":"1.00E-124"},"Rattus norvegicus strain Brown Norway clone RP31-464J4, complete sequence","P11369",55.8,3e-06,"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam07302","AroM","AroM protein. This family consists of several bacterial and archaeal AroM proteins. In Escherichia coli the aroM gene is cotranscribed with aroL. The function of this family is unknown.",".",".",".",".","."]
["ENSRNOG00000069314",0,0.04151333,8,0.514643505,0.080664246,-3.631926844,0.011481418,0.008964877,"down","yes","Lrrc3c","protein_coding","chr10:83608483-83611646:+","gi|27689263|ref|XP_220923.1|",1144,{"v":2e-147,"d":"2.00E-147"},"PREDICTED: leucine-rich repeat-containing protein 3C [Rattus norvegicus]","gi|672069267|ref|XM_220923.3|",960,0,"PREDICTED: Rattus norvegicus leucine rich repeat containing 3C (Lrrc3c), transcript variant X2, mRNA","A6NJW4",384,{"v":3e-125,"d":"3.00E-125"},"Leucine-rich repeat-containing protein 3C",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.",".",".",".",".","."]
["ENSRNOG00000017625",13,1.079346587,36,2.315895775,0.466060087,-1.101412127,0.011700006,0.009116628,"down","yes","Htr2b","protein_coding","chr9:86742102-86755108:-","gi|672065531|ref|XP_008765438.1|",2400,0,"PREDICTED: 5-hydroxytryptamine receptor 2B isoform X1 [Rattus norvegicus]","gi|672065530|ref|XM_008767216.1|",1971,0,"PREDICTED: Rattus norvegicus 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled (Htr2b), transcript variant X1, mRNA","P30994",922,0,"5-hydroxytryptamine receptor 2B",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001755|neural crest cell migration;GO:0001819|positive regulation of cytokine production;GO:0001938|positive regulation of endothelial cell proliferation;GO:0002031|G protein-coupled receptor internalization;GO:0003007|heart morphogenesis;GO:0003300|cardiac muscle hypertrophy;GO:0006874|cellular calcium ion homeostasis;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007187|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007202|activation of phospholipase C activity;GO:0007205|protein kinase C-activating G protein-coupled receptor signaling pathway;GO:0007208|phospholipase C-activating serotonin receptor signaling pathway;GO:0007268|chemical synaptic transmission;GO:0007507|heart development;GO:0008284|positive regulation of cell proliferation;GO:0009410|response to xenobiotic stimulus;GO:0010507|negative regulation of autophagy;GO:0010513|positive regulation of phosphatidylinositol biosynthetic process;GO:0014033|neural crest cell differentiation;GO:0014065|phosphatidylinositol 3-kinase signaling;GO:0014827|intestine smooth muscle contraction;GO:0016310|phosphorylation;GO:0019722|calcium-mediated signaling;GO:0019934|cGMP-mediated signaling;GO:0034220|ion transmembrane transport;GO:0035733|hepatic stellate cell activation;GO:0042310|vasoconstriction;GO:0043066|negative regulation of apoptotic process;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043406|positive regulation of MAP kinase activity;GO:0043647|inositol phosphate metabolic process;GO:0048598|embryonic morphogenesis;GO:0050795|regulation of behavior;GO:0051000|positive regulation of nitric-oxide synthase activity;GO:0051209|release of sequestered calcium ion into cytosol;GO:0051781|positive regulation of cell division;GO:0060548|negative regulation of cell death;GO:0070371|ERK1 and ERK2 cascade;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070528|protein kinase C signaling;GO:0071418|cellular response to amine stimulus;GO:0071502|cellular response to temperature stimulus;GO:0098664|G protein-coupled serotonin receptor signaling pathway;GO:1904015|cellular response to serotonin;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0030425|dendrite;GO:0043025|neuronal cell body;GO:0045202|synapse;GO:0098666|G protein-coupled serotonin receptor complex;","GO:0001587|Gq/11-coupled serotonin receptor activity;GO:0001965|G-protein alpha-subunit binding;GO:0004993|G protein-coupled serotonin receptor activity;GO:0005096|GTPase activator activity;GO:0005515|protein binding;GO:0030594|neurotransmitter receptor activity;GO:0051378|serotonin binding;","K04157","HTR2; 5-hydroxytryptamine receptor 2"]
["ENSRNOG00000032300",13,1.079346587,36,2.315895775,0.466060087,-1.101412127,0.011700006,0.009116628,"down","yes","Rpl39l","protein_coding","chr10:5454559-5462029:-","gi|655886300|ref|XP_008246941.1|",255,{"v":4e-23,"d":"4.00E-23"},"PREDICTED: 60S ribosomal protein L39 [Oryctolagus cuniculus]","gi|306922344|ref|NM_001195471.1|",508,0,"Rattus norvegicus ribosomal protein L39-like (Rpl39l), mRNA","Q90YS9",90.9,{"v":1e-20,"d":"1.00E-20"},"60S ribosomal protein L39","SPCC663.04",68.9,{"v":2e-13,"d":"2.00E-13"},"COG2167","pfam00832","Ribosomal_L39","Ribosomal L39 protein.","GO:0006412|translation;GO:0007283|spermatogenesis;","GO:0022625|cytosolic large ribosomal subunit;","GO:0003735|structural constituent of ribosome;","K02924","RP-L39e, RPL39; large subunit ribosomal protein L39e"]
["ENSRNOG00000063097",11,0.913293266,32,2.058574022,0.443653352,-1.172495225,0.012443663,0.009646711,"down","yes","ENSRNOG00000063097","lncRNA","chr2:183414511-183415673:-",".",".",".",".","gi|298903760|emb|FQ213772.1|",1154,0,"Rattus norvegicus TL0AAA45YM10 mRNA sequence",".",".",".",".",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.",".",".",".",".","."]
["ENSRNOG00000030151",7,0.581186624,24,1.543930516,0.376433147,-1.409534422,0.012513295,0.009686599,"down","yes","Thsd7a","protein_coding","chr4:40460814-40899583:-","gi|300794958|ref|NP_001178899.1|",8102,0,"thrombospondin type-1 domain-containing protein 7A precursor [Rattus norvegicus]","gi|300794957|ref|NM_001191970.1|",4936,0,"Rattus norvegicus thrombospondin, type I, domain containing 7A (Thsd7a), mRNA","Q69ZU6",3017,0,"Thrombospondin type-1 domain-containing protein 7A",".",".",".",".","pfam00090","TSP_1","Thrombospondin type 1 domain.","GO:0031532|actin cytoskeleton reorganization;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0098846|podocyte foot;",".",".","."]
["ENSRNOG00000056087",7,0.581186624,24,1.543930516,0.376433147,-1.409534422,0.012513295,0.009686599,"down","yes","Erich2","protein_coding","chr3:55310993-55347184:+","gi|66730305|ref|NP_001019482.1|",1643,0,"glutamate-rich protein 2 [Rattus norvegicus]","gi|66730304|ref|NM_001024311.1|",1653,0,"Rattus norvegicus glutamate-rich 2 (Erich2), mRNA",".",".",".",".",".",".",".",".","pfam15402","Spc7_N","N-terminus of kinetochore NMS complex subunit Spc7.",".",".",".",".","."]
["ENSRNOG00000069245",7,0.581186624,24,1.543930516,0.376433147,-1.409534422,0.012513295,0.009686599,"down","yes","ENSRNOG00000069245","protein_coding","chr17:41570273-41571049:-","gi|537211922|gb|ERE80724.1|",551,{"v":1e-67,"d":"1.00E-67"},"histone H2A type 1-F-like protein [Cricetulus griseus]","gi|56345|emb|X59961.1|",706,0,"R.norvegicus genes for H2A and H2B histones","Q8CGP5",215,{"v":9e-69,"d":"9.00E-69"},"Histone H2A type 1-F","SPCC622.08c",179,{"v":2E-55,"d":"2.00E-55"},"COG5262","pfam00125","Histone","Core histone H2A/H2B/H3/H4.",".",".",".",".","."]
["ENSRNOG00000054019",10,0.830266605,30,1.929913146,0.430209311,-1.216889345,0.012691092,0.009807609,"down","yes","SNORA72","snoRNA","chr7:65648758-65648889:-",".",".",".",".","gi|298892028|emb|FQ220874.1|",132,{"v":1E-61,"d":"1.00E-61"},"Rattus norvegicus TL0ADA41YF23 mRNA sequence",".",".",".",".",".",".",".",".","pfam09471","Peptidase_M64","IgA Peptidase M64. This is a family of highly selective metallo-endopeptidases. The primary structure of the Clostridium ramosum IgA proteinase shows no significant overall similarity to any other known metallo-endopeptidase.",".",".",".",".","."]
["ENSRNOG00000013519",3,0.249079982,15,0.964956573,0.258125587,-1.953854939,0.012760162,0.009856221,"down","yes","Tll2","protein_coding","chr1:239915508-240028120:-","gi|300798704|ref|NP_001178827.1|",5245,0,"tolloid-like protein 2 precursor [Rattus norvegicus]","gi|300798703|ref|NM_001191898.1|",3045,0,"Rattus norvegicus tolloid-like 2 (Tll2), mRNA","Q9WVM6",1959,0,"Tolloid-like protein 2",".",".",".",".","pfam01400","Astacin","Astacin (Peptidase family M12A). The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family contain two conserved disulphide bridges, these are joined 1-4 and 2-3. Members of this family have an amino terminal propeptide which is cleaved to give the active protease domain. All other linked domains are found to the carboxyl terminus of this domain. This family includes: Astacin, a digestive enzyme from Crayfish. Meprin, a multiple domain membrane component that is constructed from a homologous alpha and beta chain. Proteins involved in morphogenesis, and Tolloid from drosophila.","GO:0006508|proteolysis;GO:0030154|cell differentiation;GO:0048632|negative regulation of skeletal muscle tissue growth;",".","GO:0004222|metalloendopeptidase activity;GO:0005509|calcium ion binding;GO:0008270|zinc ion binding;","K13047","TLL2; tolloid-like protein 2 [EC:3.4.24.-]"]
["ENSRNOG00000065792",3,0.249079982,15,0.964956573,0.258125587,-1.953854939,0.012760162,0.009856221,"down","yes","Olr837","protein_coding","chr5:58031445-58035562:-","gi|47576753|ref|NP_001000897.1|",1513,0,"olfactory receptor Olr837 [Rattus norvegicus]","gi|47576752|ref|NM_001000897.1|",948,0,"Rattus norvegicus olfactory receptor 837 (Olr837), mRNA","P0DN81",536,0,"Olfactory receptor 13C7",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.",".",".",".",".","."]
["ENSRNOG00000068252",3,0.249079982,15,0.964956573,0.258125587,-1.953854939,0.012760162,0.009856221,"down","yes","Olr1646","protein_coding","chr15:27729827-27736945:-","gi|47576567|ref|NP_001000103.1|",1426,{"v":3e-177,"d":"3.00E-177"},"olfactory receptor Olr1646 [Rattus norvegicus]","gi|218511252|gb|AC097037.8|",6375,0,"Rattus norvegicus CH230-20D8 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q9Z1V0",514,{"v":9e-165,"d":"9.00E-165"},"Olfactory receptor 49",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.",".",".",".",".","."]
["ENSRNOG00000055361",8,0.664213284,26,1.672591393,0.397116287,-1.332366562,0.012771648,0.009862711,"down","yes","SNORD18","snoRNA","chr8:64673656-64673726:+",".",".",".",".","gi|908663639|tpe|LN872817.1|",65,{"v":9e-25,"d":"9.00E-25"},"TPA: Mus musculus SNORD18 gene for small nucleolar RNA SNORD18",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["ENSRNOG00000068158",9,0.747239945,28,1.801252269,0.414844693,-1.269356764,0.012814082,0.009888314,"down","yes","ENSRNOG00000068158","lncRNA","chr11:70709097-70740454:+",".",".",".",".","gi|354792375|gb|JN956876.1|",236,{"v":4e-118,"d":"4.00E-118"},"Mus musculus targeted deletion, lacZ-tagged mutant allele Hes1:tm1(KOMP)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam06087","Tyr-DNA_phospho","Tyrosyl-DNA phosphodiesterase. Covalent intermediates between topoisomerase I and DNA can become dead-end complexes that lead to cell death. Tyrosyl-DNA phosphodiesterase can hydrolyse the bond between topoisomerase I and DNA.",".",".",".",".","."]
["ENSRNOG00000007461",15,1.245399908,39,2.508887089,0.496395359,-1.010438467,0.014464234,0.011027282,"down","yes","Klhl41","protein_coding","chr3:54434234-54449222:+","gi|17105344|ref|NP_476539.1|",3143,0,"kelch-like protein 41 [Rattus norvegicus]","gi|17105343|ref|NM_057191.1|",2274,0,"Rattus norvegicus kelch-like family member 41 (Klhl41), mRNA","Q9ER30",1215,0,"Kelch-like protein 41",".",".",".",".","pfam07707","BACK","BTB And C-terminal Kelch. This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).","GO:0016567|protein ubiquitination;GO:0030239|myofibril assembly;GO:0035914|skeletal muscle cell differentiation;GO:0045214|sarcomere organization;GO:0045661|regulation of myoblast differentiation;GO:0048741|skeletal muscle fiber development;GO:2000291|regulation of myoblast proliferation;GO:2001014|regulation of skeletal muscle cell differentiation;","GO:0001726|ruffle;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005789|endoplasmic reticulum membrane;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0031143|pseudopodium;GO:0031430|M band;GO:0031463|Cul3-RING ubiquitin ligase complex;GO:0033017|sarcoplasmic reticulum membrane;","GO:0005515|protein binding;","K10473","KBTBD5_10; kelch repeat and BTB domain-containing protein 5/10"]
["ENSRNOG00000055499",15,1.245399908,39,2.508887089,0.496395359,-1.010438467,0.014464234,0.011027282,"down","yes","Grid1","protein_coding","chr16:10138925-10885808:+","gi|13259380|ref|NP_077354.1|",5250,0,"glutamate receptor ionotropic, delta-1 precursor [Rattus norvegicus]","gi|13259379|ref|NM_024378.1|",3323,0,"Rattus norvegicus glutamate ionotropic receptor delta type subunit 1 (Grid1), mRNA","Q62640",2027,0,"Glutamate receptor ionotropic, delta-1","alr3187_1",59.3,1E-8,"COG0834","pfam00060","Lig_chan","Ligand-gated ion channel. This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.","GO:0034220|ion transmembrane transport;GO:0035176|social behavior;GO:0035235|ionotropic glutamate receptor signaling pathway;GO:0035249|synaptic transmission, glutamatergic;GO:0050804|modulation of chemical synaptic transmission;GO:0060078|regulation of postsynaptic membrane potential;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0045211|postsynaptic membrane;GO:0098978|glutamatergic synapse;GO:0099061|integral component of postsynaptic density membrane;","GO:0004970|ionotropic glutamate receptor activity;GO:0008066|glutamate receptor activity;GO:0015276|ligand-gated ion channel activity;GO:0038023|signaling receptor activity;GO:0042802|identical protein binding;GO:1904315|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K05206","GRID1; glutamate receptor delta-1 subunit"]
["ENSRNOG00000004275",4,0.332106642,17,1.093617449,0.303677161,-1.719389685,0.015106311,0.011443743,"down","yes","Egfl6","protein_coding","chrX:27884125-27942044:+","gi|672087357|ref|XP_008771393.1|",2660,0,"PREDICTED: epidermal growth factor-like protein 6 isoform X1 [Rattus norvegicus]","gi|672087356|ref|XM_008773171.1|",2582,0,"PREDICTED: Rattus norvegicus EGF-like-domain, multiple 6 (Egfl6), transcript variant X1, mRNA","Q9JJZ5",945,0,"Epidermal growth factor-like protein 6",".",".",".",".","pfam00629","MAM","MAM domain. An extracellular domain found in many receptors.","GO:0007155|cell adhesion;GO:0010811|positive regulation of cell-substrate adhesion;GO:0030198|extracellular matrix organization;","GO:0005604|basement membrane;GO:0016020|membrane;GO:0031012|extracellular matrix;","GO:0005178|integrin binding;GO:0005509|calcium ion binding;","K25527","EGFL6, MAEG; epidermal growth factor-like protein 6"]
["ENSRNOG00000010262",4,0.332106642,17,1.093617449,0.303677161,-1.719389685,0.015106311,0.011443743,"down","yes","Hdc","protein_coding","chr3:113847260-113865341:-","gi|158186734|ref|NP_058712.2|",3475,0,"histidine decarboxylase [Rattus norvegicus]","gi|158186733|ref|NM_017016.2|",2338,0,"Rattus norvegicus histidine decarboxylase (Hdc), mRNA","P16453",1333,0,"Histidine decarboxylase","mll0712",288,{"v":4e-87,"d":"4.00E-87"},"COG0076","pfam00282","Pyridoxal_deC","Pyridoxal-dependent decarboxylase conserved domain.","GO:0001692|histamine metabolic process;GO:0001694|histamine biosynthetic process;GO:0006520|cellular amino acid metabolic process;GO:0006547|histidine metabolic process;GO:0006548|histidine catabolic process;GO:0042423|catecholamine biosynthetic process;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0030425|dendrite;GO:0043025|neuronal cell body;","GO:0004398|histidine decarboxylase activity;GO:0016597|amino acid binding;GO:0016831|carboxy-lyase activity;GO:0030170|pyridoxal phosphate binding;GO:0042802|identical protein binding;","K01590","hdc, HDC; histidine decarboxylase [EC:4.1.1.22]"]
["ENSRNOG00000014201",4,0.332106642,17,1.093617449,0.303677161,-1.719389685,0.015106311,0.011443743,"down","yes","ENSRNOG00000014201","protein_coding","chr8:107548352-107551438:-","gi|110625813|ref|NP_083379.2|",794,{"v":1e-101,"d":"1.00E-101"},"mesencephalic astrocyte-derived neurotrophic factor precursor [Mus musculus]","gi|564365477|ref|XM_006243775.1|",728,0,"PREDICTED: Rattus norvegicus mesencephalic astrocyte-derived neurotrophic factor (Manf), transcript variant X1, mRNA","P0C5H9",310,{"v":4e-103,"d":"4.00E-103"},"Mesencephalic astrocyte-derived neurotrophic factor",".",".",".",".","pfam10208","Armet","Degradation arginine-rich protein for mis-folding. This is a family of small proteins of approximately 170 residues which contain four di-sulfide bridges that are highly conserved from nematodes to humans. Armet is a soluble protein resident in the endoplasmic reticulum and induced by ER stress. It appears to be involved with dealing with mis-folded proteins in the ER, thus in quality control of ER stress.","GO:0002014|vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure;GO:0006986|response to unfolded protein;GO:0007165|signal transduction;GO:0008150|biological_process;GO:0031175|neuron projection development;GO:0071542|dopaminergic neuron differentiation;GO:1905897|regulation of response to endoplasmic reticulum stress;","GO:0005615|extracellular space;GO:0005783|endoplasmic reticulum;GO:0005788|endoplasmic reticulum lumen;GO:0033018|sarcoplasmic reticulum lumen;GO:0048471|perinuclear region of cytoplasm;","GO:0003674|molecular_function;GO:0008083|growth factor activity;GO:0120146|sulfatide binding;","K22556","MANF, ARMET; mesencephalic astrocyte-derived neurotrophic factor"]
["ENSRNOG00000032832",4,0.332106642,17,1.093617449,0.303677161,-1.719389685,0.015106311,0.011443743,"down","yes","Mmp10","protein_coding","chr8:4689840-4697748:+","gi|149020726|gb|EDL78531.1|",2457,0,"rCG31835 [Rattus norvegicus]","gi|57388|emb|X05083.1|",1702,0,"RAT mRNA for oncogene-induced transin-2","P07152",947,0,"Stromelysin-2",".",".",".",".","pfam00413","Peptidase_M10","Matrixin. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.","GO:0006508|proteolysis;GO:0030198|extracellular matrix organization;GO:0030334|regulation of cell migration;GO:0030574|collagen catabolic process;","GO:0005576|extracellular region;GO:0031012|extracellular matrix;","GO:0004222|metalloendopeptidase activity;GO:0008270|zinc ion binding;","K01396","MMP10; matrix metalloproteinase-10 (stromelysin 2) [EC:3.4.24.22]"]
["ENSRNOG00000050602",4,0.332106642,17,1.093617449,0.303677161,-1.719389685,0.015106311,0.011443743,"down","yes","Kif28p","protein_coding","chr13:91427736-91482237:-","gi|393393850|ref|NP_001257314.1|",5134,0,"kinesin-like protein KIF28P [Rattus norvegicus]","gi|393393849|ref|NM_001270385.1|",3105,0,"Rattus norvegicus kinesin family member 28, pseudogene (Kif28p), mRNA","F8WLE0",1982,0,"Kinesin-like protein KIF28P","SPAC1834.07",211,{"v":2e-57,"d":"2.00E-57"},"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0007005|mitochondrion organization;GO:0007018|microtubule-based movement;GO:0072384|organelle transport along microtubule;","GO:0005871|kinesin complex;GO:0005874|microtubule;GO:0031966|mitochondrial membrane;","GO:0003777|microtubule motor activity;GO:0005524|ATP binding;GO:0008017|microtubule binding;GO:0016887|ATPase activity;",".","."]
["ENSRNOG00000051630",4,0.332106642,17,1.093617449,0.303677161,-1.719389685,0.015106311,0.011443743,"down","yes","AABR07069587.2","lncRNA","chr8:29911090-29977779:+",".",".",".",".","gi|77020636|gb|AC167244.2|",158,{"v":4e-75,"d":"4.00E-75"},"Mus musculus BAC clone RP24-84C23 from chromosome 9, complete sequence",".",".",".",".",".",".",".",".","pfam00003","7tm_3","7 transmembrane sweet-taste receptor of 3 GCPR. This is a domain of seven transmembrane regions that forms the C-terminus of some subclass 3 G-coupled-protein receptors. It is often associated with a downstream cysteine-rich linker domain, NCD3G pfam07562, which is the human sweet-taste receptor, and the N-terminal domain, ANF_receptor pfam01094. The seven TM regions assemble in such a way as to produce a docking pocket into which such molecules as cyclamate and lactisole have been found to bind and consequently confer the taste of sweetness.",".",".",".",".","."]
["ENSRNOG00000069130",4,0.332106642,17,1.093617449,0.303677161,-1.719389685,0.015106311,0.011443743,"down","yes","ENSRNOG00000069130","protein_coding","chr2:23585644-23607712:+","gi|45478192|gb|AAS66267.1|",1819,0,"LRRGT00176 [Rattus norvegicus]","gi|50838842|gb|AC099449.6|",2399,0,"Rattus norvegicus 1 BAC CH230-57B2 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P11260",496,{"v":3E-160,"d":"3.00E-160"},"LINE-1 retrotransposable element ORF1 protein","SPCC1223.08c_2",103,{"v":4e-23,"d":"4.00E-23"},"COG0262","pfam02994","Transposase_22","L1 transposable element.",".",".",".",".","."]
["ENSRNOG00000055716",14,1.162373247,37,2.380226213,0.488345705,-1.034025287,0.015196916,0.011504932,"down","yes","Oscar","protein_coding","chr1:65607410-65613758:+","gi|564325642|ref|XP_006228082.1|",1273,{"v":1e-157,"d":"1.00E-157"},"PREDICTED: osteoclast-associated immunoglobulin-like receptor isoform X1 [Rattus norvegicus]","gi|34368610|gb|AC103574.7|",4382,0,"Rattus norvegicus 1 BAC CH230-205C19 (Children's Hospital Oakland Research Institute) complete sequence","Q8VBT3",417,{"v":3E-131,"d":"3.00E-131"},"Osteoclast-associated immunoglobulin-like receptor",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0030316|osteoclast differentiation;GO:0038065|collagen-activated signaling pathway;GO:0038094|Fc-gamma receptor signaling pathway;GO:0045780|positive regulation of bone resorption;GO:0072674|multinuclear osteoclast differentiation;","GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0038064|collagen receptor activity;","K14377","OSCAR; osteoclast-associated immunoglobulin-like receptor"]
["ENSRNOG00000010963",2,0.166053321,12,0.771965258,0.215104656,-2.216889345,0.015746685,0.011876143,"down","yes","RGD1563222","protein_coding","chr3:90484607-90486589:+","gi|157819727|ref|NP_001102055.1|",658,{"v":5e-83,"d":"5.00E-83"},"uncharacterized protein C11orf91 homolog [Rattus norvegicus]","gi|672046418|ref|XM_008762066.1|",815,0,"PREDICTED: Rattus norvegicus similar to RIKEN cDNA A930018P22 (RGD1563222), transcript variant X5, mRNA",".",".",".",".",".",".",".",".","pfam15119","APOC4","Apolipoprotein C4.",".",".",".",".","."]
["ENSRNOG00000050091",2,0.166053321,12,0.771965258,0.215104656,-2.216889345,0.015746685,0.011876143,"down","yes","Efcab1","protein_coding","chr11:85983304-85996538:-","gi|157817833|ref|NP_001100400.1|",1048,{"v":1E-139,"d":"1.00E-139"},"EF-hand calcium-binding domain-containing protein 1 [Rattus norvegicus]","gi|157817832|ref|NM_001106930.1|",1198,0,"Rattus norvegicus EF hand calcium binding domain 1 (Efcab1), mRNA","Q9D3N2",389,{"v":1e-133,"d":"1.00E-133"},"EF-hand calcium-binding domain-containing protein 1","YKL190w",77.4,{"v":8e-16,"d":"8.00E-16"},"COG5126","pfam13499","EF-hand_7","EF-hand domain pair.",".",".","GO:0005509|calcium ion binding;",".","."]
["ENSRNOG00000063651",2,0.166053321,12,0.771965258,0.215104656,-2.216889345,0.015746685,0.011876143,"down","yes","ENSRNOG00000063651","lncRNA","chr20:17943254-18024429:-","gi|148677466|gb|EDL09413.1|",185,{"v":8E-14,"d":"8.00E-14"},"mCG147326 [Mus musculus]","gi|672031653|ref|XR_599394.1|",583,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102548544 (LOC102548544), ncRNA",".",".",".",".",".",".",".",".","pfam04632","FUSC","Fusaric acid resistance protein family. This family includes a conserved region found in two proteins associated with fusaric acid resistance, from Burkholderia cepacia and Klebsiella oxytoca. These proteins are likely to be membrane transporter proteins.",".",".",".",".","."]
["ENSRNOG00000069700",2,0.166053321,12,0.771965258,0.215104656,-2.216889345,0.015746685,0.011876143,"down","yes","ENSRNOG00000069700","lncRNA","chr3:162425598-162427105:-",".",".",".",".","gi|672017823|ref|XR_600520.1|",113,{"v":6e-50,"d":"6.00E-50"},"PREDICTED: Rattus norvegicus uncharacterized LOC103691987 (LOC103691987), ncRNA",".",".",".",".",".",".",".",".","pfam00771","FHIPEP","FHIPEP family.",".",".",".",".","."]
["ENSRNOG00000010106",13,1.079346587,35,2.251565336,0.47937609,-1.060770143,0.015908911,0.011980124,"down","yes","Faxc","protein_coding","chr5:35480402-35544446:+","gi|585155919|ref|XP_006730289.1|",928,{"v":1E-174,"d":"1.00E-174"},"PREDICTED: failed axon connections homolog [Leptonychotes weddellii]","gi|672052183|ref|XM_006237944.2|",5373,0,"PREDICTED: Rattus norvegicus failed axon connections homolog (Drosophila) (Faxc), transcript variant X1, mRNA","D3ZAT9",371,{"v":8e-113,"d":"8.00E-113"},"Failed axon connections homolog",".",".",".",".","pfam14497","GST_C_3","Glutathione S-transferase, C-terminal domain. This domain is closely related to pfam00043.",".","GO:0005737|cytoplasm;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000017828",12,0.996319926,33,2.12290446,0.469319249,-1.091358462,0.01658078,0.012447955,"down","yes","Egr3","protein_coding","chr15:45150567-45154627:+","gi|119584053|gb|EAW63649.1|",2126,0,"early growth response 3 [Homo sapiens]","gi|186660186|gb|AC111804.5|",2301,0,"Rattus norvegicus BAC CH230-27O13 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P43301",801,0,"Early growth response protein 3","SPAC4G8.13c",86.3,{"v":2E-16,"d":"2.00E-16"},"COG5048","pfam11928","DUF3446","Domain of unknown function (DUF3446). This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 80 to 99 amino acids in length. This domain is found associated with pfam00096. This domain has a single completely conserved residue P that may be functionally important.","GO:0001938|positive regulation of endothelial cell proliferation;GO:0002042|cell migration involved in sprouting angiogenesis;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007274|neuromuscular synaptic transmission;GO:0007422|peripheral nervous system development;GO:0033089|positive regulation of T cell differentiation in thymus;GO:0035767|endothelial cell chemotaxis;GO:0035924|cellular response to vascular endothelial growth factor stimulus;GO:0043066|negative regulation of apoptotic process;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0045586|regulation of gamma-delta T cell differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;GO:0045202|synapse;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0043565|sequence-specific DNA binding;GO:0046872|metal ion binding;GO:1990837|sequence-specific double-stranded DNA binding;","K12497","EGR3; early growth response protein 3"]
["ENSRNOG00000018870",12,0.996319926,33,2.12290446,0.469319249,-1.091358462,0.01658078,0.012447955,"down","yes","Hapln2","protein_coding","chr2:173491160-173496588:-","gi|564337391|ref|XP_006232813.1|",1708,0,"PREDICTED: hyaluronan and proteoglycan link protein 2 isoform X1 [Rattus norvegicus]","gi|672043127|ref|XM_008761208.1|",1382,0,"PREDICTED: Rattus norvegicus hyaluronan and proteoglycan link protein 2 (Hapln2), transcript variant X1, mRNA","Q9ESM2",660,0,"Hyaluronan and proteoglycan link protein 2",".",".",".",".","pfam00193","Xlink","Extracellular link domain.","GO:0001501|skeletal system development;GO:0007155|cell adhesion;GO:0007417|central nervous system development;GO:0008065|establishment of blood-nerve barrier;GO:0085029|extracellular matrix assembly;","GO:0005576|extracellular region;GO:0031012|extracellular matrix;","GO:0005540|hyaluronic acid binding;","K06851","HAPLN2; hyaluronan and proteoglycan link protein 2"]
["ENSRNOG00000022248",12,0.996319926,33,2.12290446,0.469319249,-1.091358462,0.01658078,0.012447955,"down","yes","Fbxl16","protein_coding","chr10:14829449-14840986:+","gi|625196105|ref|XP_003501609.2|",2131,0,"PREDICTED: F-box/LRR-repeat protein 16 isoform X3 [Cricetulus griseus]","gi|672066960|ref|XM_006246020.2|",2758,0,"PREDICTED: Rattus norvegicus F-box and leucine-rich repeat protein 16 (Fbxl16), transcript variant X1, mRNA","Q5MJ12",817,0,"F-box/LRR-repeat protein 16",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.","GO:0031146|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;","GO:0005737|cytoplasm;GO:0019005|SCF ubiquitin ligase complex;",".","K10282","FBXL16; F-box and leucine-rich repeat protein 16"]
["ENSRNOG00000066918",5,0.415133303,19,1.222278326,0.33963893,-1.557926262,0.01668422,0.012515325,"down","yes","ENSRNOG00000066918","lncRNA","chr9:23830201-23832820:-",".",".",".",".","gi|30581645|gb|AC095904.7|",2620,0,"Rattus norvegicus 9 BAC CH230-10L20 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam09531","Ndc1_Nup","Nucleoporin protein Ndc1-Nup. Ndc1 is a nucleoporin protein that is a component of the Nuclear Pore Complex, and, in fungi, also of the Spindle Pole Body. It consists of six transmembrane segments, three lumenal loops, both concentrated at the N-terminus and cytoplasmic domains largely at the C-terminus, all of which are well conserved.",".",".",".",".","."]
["ENSRNOG00000000973",1,0.083026661,9,0.578973944,0.143403104,-2.801851845,0.016929193,0.01265603,"down","yes","Tex45","protein_coding","chr12:1521014-1538118:+","gi|157818089|ref|NP_001102529.1|",2389,0,"uncharacterized protein C19orf45 homolog [Rattus norvegicus]","gi|672072053|ref|XM_008768988.1|",1624,0,"PREDICTED: Rattus norvegicus similar to FLJ35784 protein (RGD1563425), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam15373","DUF4601","Domain of unknown function (DUF4601). This protein family is a domain of unknown function, which is found in eukaryotes. In humans, the gene encoding this protein is found in the position, chromosome 19 open reading frame 45.",".",".",".",".","."]
["ENSRNOG00000005792",1,0.083026661,9,0.578973944,0.143403104,-2.801851845,0.016929193,0.01265603,"down","yes","Ankef1","protein_coding","chr3:123847817-123883059:+","gi|157817863|ref|NP_001099986.1|",4075,0,"ankyrin repeat and EF-hand domain-containing protein 1 [Rattus norvegicus]","gi|672047197|ref|XR_591686.1|",3100,0,"PREDICTED: Rattus norvegicus ankyrin repeat and EF-hand domain containing 1 (Ankef1), transcript variant X6, misc_RNA",".",".",".",".","all2748",96.3,{"v":5e-20,"d":"5.00E-20"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).",".",".",".",".","."]
["ENSRNOG00000013209",1,0.083026661,9,0.578973944,0.143403104,-2.801851845,0.016929193,0.01265603,"down","yes","Barhl1","protein_coding","chr3:12241327-12248649:-","gi|148676454|gb|EDL08401.1|",1440,0,"BarH-like 1 (Drosophila), isoform CRA_b, partial [Mus musculus]","gi|16923955|ref|NM_057109.1|",2386,0,"Rattus norvegicus BarH-like homeobox 1 (Barhl1), mRNA","P63156",554,0,"BarH-like 1 homeobox protein",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0001764|neuron migration;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007605|sensory perception of sound;GO:0030901|midbrain development;GO:0043524|negative regulation of neuron apoptotic process;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837|sequence-specific double-stranded DNA binding;","K09360","BARHL; BarH-like"]
["ENSRNOG00000035553",1,0.083026661,9,0.578973944,0.143403104,-2.801851845,0.016929193,0.01265603,"down","yes","Mir202","miRNA","chr1:194754730-194754801:-",".",".",".",".","gi|297139716|ref|NR_032736.1|",72,{"v":1e-28,"d":"1.00E-28"},"Rattus norvegicus microRNA 202 (Mir202), microRNA",".",".",".",".",".",".",".",".","pfam05717","TnpB_IS66","IS66 Orf2 like protein. This protein is found in insertion sequences related to IS66. The function of these proteins is uncertain, but they are probably essential for transposition.","GO:0046661|male sex differentiation;GO:0071222|cellular response to lipopolysaccharide;",".",".","K17149","MIR202; microRNA 202"]
["ENSRNOG00000046776",1,0.083026661,9,0.578973944,0.143403104,-2.801851845,0.016929193,0.01265603,"down","yes","Msx3","protein_coding","chr1:194839041-194841969:-","gi|30704771|gb|AAH51983.1|",721,{"v":4e-86,"d":"4.00E-86"},"Msx3 protein, partial [Mus musculus]","gi|282154796|ref|NM_053712.1|",2310,0,"Rattus norvegicus msh homeobox 3 (Msx3), mRNA","P70354",267,{"v":3e-82,"d":"3.00E-82"},"Homeobox protein MSX-3",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008150|biological_process;GO:0035067|negative regulation of histone acetylation;GO:0048598|embryonic morphogenesis;","GO:0005575|cellular_component;GO:0005634|nucleus;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003674|molecular_function;","K09341","MSX; homeobox protein MSX"]
["ENSRNOG00000053830",1,0.083026661,9,0.578973944,0.143403104,-2.801851845,0.016929193,0.01265603,"down","yes","AC133055.1","snoRNA","chr10:91190227-91190352:+",".",".",".",".","gi|908663275|tpe|LN872480.1|",83,{"v":2e-34,"d":"2.00E-34"},"TPA: Mus musculus SNORA51 (ACA51) gene for small nucleolar RNA SNORA51 (ACA51)",".",".",".",".",".",".",".",".","pfam08424","NRDE-2","NRDE-2, necessary for RNA interference. This is a family of eukaryotic proteins. Eukaryotic cells express a wide variety of endogenous small regulatory RNAs that regulate heterochromatin formation, developmental timing, defence against parasitic nucleic acids, and genome rearrangement. Many small regulatory RNAs are thought to function in nuclei, and in plants and fungi small interfering (si)RNAs associate with nascent transcripts and direct chromatin and/or DNA modifications. This family protein, NRDE-2, is required for small interfering (si)RNA-mediated silencing in nuclei. NRDE-2 associates with the Argonaute protein NRDE-3 within nuclei and is recruited by NRDE-3/siRNA complexes to nascent transcripts that have been targeted by RNA interference, RNAi, the process whereby double-stranded RNA (dsRNA) directs the sequence-specific degradation of mRNA.",".",".",".",".","."]
["ENSRNOG00000055675",1,0.083026661,9,0.578973944,0.143403104,-2.801851845,0.016929193,0.01265603,"down","yes","Gm22486","snoRNA","chr4:103924328-103924464:-",".",".",".",".","gi|908663751|tpe|LN872920.1|",119,{"v":2e-54,"d":"2.00E-54"},"TPA: Mus musculus SNORD94 gene for small nucleolar RNA SNORD94",".",".",".",".",".",".",".",".","pfam02399","Herpes_ori_bp","Origin of replication binding protein. This Pfam family represents the herpesvirus origin of replication binding protein, probably involved in DNA replication.",".",".",".",".","."]
["ENSRNOG00000062603",1,0.083026661,9,0.578973944,0.143403104,-2.801851845,0.016929193,0.01265603,"down","yes","ENSRNOG00000062603","lncRNA","chr14:95591640-95599406:+","gi|148698732|gb|EDL30679.1|",171,{"v":2e-11,"d":"2.00E-11"},"mCG148064 [Mus musculus]","gi|24366514|emb|AL772195.4|",259,{"v":7e-131,"d":"7.00E-131"},"Mouse DNA sequence from clone RP23-218C5 on chromosome 11, complete sequence",".",".",".",".",".",".",".",".","pfam01221","Dynein_light","Dynein light chain type 1.",".",".",".",".","."]
["ENSRNOG00000062961",1,0.083026661,9,0.578973944,0.143403104,-2.801851845,0.016929193,0.01265603,"down","yes","ENSRNOG00000062961","lncRNA","chr1:35318705-35326361:-","gi|672064193|ref|XP_008765045.1|",304,{"v":1e-29,"d":"1.00E-29"},"PREDICTED: uncharacterized protein LOC685976 isoform X4 [Rattus norvegicus]","gi|672042620|ref|XR_591124.1|",476,0,"PREDICTED: Rattus norvegicus similar to nidogen 2 (LOC365085), transcript variant X16, misc_RNA","Q8R1R5",89.7,{"v":9e-19,"d":"9.00E-19"},"CD99 antigen-like protein 2",".",".",".",".","pfam06022","Cir_Bir_Yir","Plasmodium variant antigen protein Cir/Yir/Bir. This family consists of several Cir, Yir and Bir proteins from the Plasmodium species P.chabaudi, P.yoelii and P.berghei.",".",".",".",".","."]
["ENSRNOG00000063403",1,0.083026661,9,0.578973944,0.143403104,-2.801851845,0.016929193,0.01265603,"down","yes","ENSRNOG00000063403","lncRNA","chr2:196582337-196586744:-","gi|12838632|dbj|BAB24270.1|",284,{"v":3e-26,"d":"3.00E-26"},"unnamed protein product [Mus musculus]","gi|24743322|emb|AL671894.20|",480,0,"Mouse DNA sequence from clone RP23-316M11 on chromosome 3, complete sequence",".",".",".",".",".",".",".",".","pfam15635","Tox-GHH2","GHH signature containing HNH/Endo VII superfamily nuclease toxin 2. A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteristic s[AGP]HH signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or type secretion system.",".",".",".",".","."]
["ENSRNOG00000065859",1,0.083026661,9,0.578973944,0.143403104,-2.801851845,0.016929193,0.01265603,"down","yes","SNORD63","snoRNA","chr18:26540137-26540204:-",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","pfam03254","XG_FTase","Xyloglucan fucosyltransferase. Plant cell walls are crucial for development, signal transduction, and disease resistance in plants. Cell walls are made of cellulose, hemicelluloses, and pectins. Xyloglucan (XG), the principal load-bearing hemicellulose of dicotyledonous plants, has a terminal fucosyl residue. This fucosyltransferase adds this residue.",".",".",".",".","."]
["ENSRNOG00000068353",1,0.083026661,9,0.578973944,0.143403104,-2.801851845,0.016929193,0.01265603,"down","yes","ENSRNOG00000068353","protein_coding","chr1:258030937-258037823:+","gi|975107385|ref|XP_015269135.1|",539,{"v":1e-68,"d":"1.00E-68"},"PREDICTED: transcription elongation factor SPT4 isoform X1 [Gekko japonicus]","gi|298894371|emb|FQ224188.1|",261,{"v":7e-133,"d":"7.00E-133"},"Rattus norvegicus TL0ACA74YF17 mRNA sequence","Q4R941",209,{"v":5e-69,"d":"5.00E-69"},"Transcription elongation factor SPT4","ECU08g1660",85.1,{"v":6e-21,"d":"6.00E-21"},"COG5204","pfam06093","Spt4","Spt4/RpoE2 zinc finger. This family consists of several eukaryotic transcription elongation Spt4 proteins as well as archaebacterial RpoE2. Three transcription-elongation factors Spt4, Spt5, and Spt6 are conserved among eukaryotes and are essential for transcription via the modulation of chromatin structure. Spt4 and Spt5 are tightly associated in a complex, while the physical association of the Spt4-Spt5 complex with Spt6 is considerably weaker. It has been demonstrated that Spt4, Spt5, and Spt6 play roles in transcription elongation in both yeast and humans including a role in activation by Tat. It is known that Spt4, Spt5, and Spt6 are general transcription-elongation factors, controlling transcription both positively and negatively in important regulatory and developmental roles. RpoE2 is one of 13 subunits in the archaeal RNA polymerase. These proteins contain a C4-type zinc finger, and the structure has been solved in. The structure reveals that Spt4-Spt5 binding is governed by an acid-dipole interaction between Spt5 and Spt4, and the complex binds to and travels along the elongating RNA polymerase. The Spt4-Spt5 complex is likely to be an ancient, core component of the transcription elongation machinery.",".",".",".",".","."]
["ENSRNOG00000068793",1,0.083026661,9,0.578973944,0.143403104,-2.801851845,0.016929193,0.01265603,"down","yes","ENSRNOG00000068793","protein_coding","chr18:55573642-55573960:-","gi|528759865|gb|EPY79524.1|",304,{"v":4e-31,"d":"4.00E-31"},"proteinase-activated receptor 1 [Camelus ferus]","gi|672041289|ref|XM_008760685.1|",179,{"v":1E-87,"d":"1.00E-87"},"PREDICTED: Rattus norvegicus IQ motif containing GTPase activating protein 2 (Iqgap2), transcript variant X3, mRNA","Q3UQ44",117,{"v":2e-30,"d":"2.00E-30"},"Ras GTPase-activating-like protein IQGAP2",".",".",".",".","pfam03836","RasGAP_C","RasGAP C-terminus.",".",".",".",".","."]
["ENSRNOG00000068851",1,0.083026661,9,0.578973944,0.143403104,-2.801851845,0.016929193,0.01265603,"down","yes","ENSRNOG00000068851","lncRNA","chr3:104330477-104340411:+","gi|449269011|gb|EMC79822.1|",167,{"v":2e-10,"d":"2.00E-10"},"hypothetical protein A306_12632, partial [Columba livia]","gi|28372104|emb|AL929110.10|",387,0,"Mouse DNA sequence from clone RP23-275P20 on chromosome 2, complete sequence",".",".",".",".",".",".",".",".","pfam02389","Cornifin","Cornifin (SPRR) family. SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteristic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid.",".",".",".",".","."]
["ENSRNOG00000070307",1,0.083026661,9,0.578973944,0.143403104,-2.801851845,0.016929193,0.01265603,"down","yes","ENSRNOG00000070307","lncRNA","chr6:88958917-88960555:+",".",".",".",".","gi|354797392|gb|JN961893.1|",384,0,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Tmx1:tm1a(EUCOMM)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam13761","DUF4166","Domain of unknown function (DUF4166). This domain is often found at the C-terminus of proteins containing pfam03435.",".",".",".",".","."]
["ENSRNOG00000005003",11,0.913293266,31,1.994243584,0.457964751,-1.126691536,0.017186954,0.012830726,"down","yes","Ptprn2","protein_coding","chr6:137439540-138191575:+","gi|13928818|ref|NP_113788.1|",4923,0,"receptor-type tyrosine-protein phosphatase N2 precursor [Rattus norvegicus]","gi|13928817|ref|NM_031600.1|",4878,0,"Rattus norvegicus protein tyrosine phosphatase, receptor type N2 (Ptprn2), mRNA","Q63475",1902,0,"Receptor-type tyrosine-protein phosphatase N2","SPAC26F1.10c",127,{"v":2e-29,"d":"2.00E-29"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0006629|lipid metabolic process;GO:0007269|neurotransmitter secretion;GO:0034260|negative regulation of GTPase activity;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0035773|insulin secretion involved in cellular response to glucose stimulus;","GO:0005737|cytoplasm;GO:0005788|endoplasmic reticulum lumen;GO:0030141|secretory granule;GO:0030285|integral component of synaptic vesicle membrane;GO:0030667|secretory granule membrane;GO:0030672|synaptic vesicle membrane;GO:0043195|terminal bouton;GO:0043235|receptor complex;","GO:0004725|protein tyrosine phosphatase activity;GO:0005515|protein binding;","K07817","PTPRN; receptor-type tyrosine-protein phosphatase N [EC:3.1.3.48]"]
["ENSRNOG00000022723",11,0.913293266,31,1.994243584,0.457964751,-1.126691536,0.017186954,0.012830726,"down","yes","RGD1562029","protein_coding","chr9:60968310-61075626:+","gi|672024113|ref|XP_008756273.1|",3648,0,"PREDICTED: uncharacterized protein KIAA2012 homolog [Rattus norvegicus]","gi|672024112|ref|XM_008758051.1|",2127,0,"PREDICTED: Rattus norvegicus similar to KIAA2012 protein (RGD1562029), mRNA",".",".",".",".",".",".",".",".","pfam06728","PIG-U","GPI transamidase subunit PIG-U. Many eukaryotic proteins are anchored to the cell surface via glycosylphosphatidylinositol (GPI), which is posttranslationally attached to the carboxyl-terminus by GPI transamidase. The mammalian GPI transamidase is a complex of at least four subunits, GPI8, GAA1, PIG-S, and PIG-T. PIG-U is thought to represent a fifth subunit in this complex and may be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.",".",".",".",".","."]
["ENSRNOG00000036680",11,0.913293266,31,1.994243584,0.457964751,-1.126691536,0.017186954,0.012830726,"down","yes","Notum","protein_coding","chr10:105933249-105940315:-","gi|564375622|ref|XP_006247949.1|",2334,0,"PREDICTED: protein notum homolog isoform X1 [Rattus norvegicus]","gi|195927012|ref|NM_001013975.2|",2041,0,"Rattus norvegicus notum pectinacetylesterase homolog (Drosophila) (Notum), mRNA","Q8R116",888,0,"Palmitoleoyl-protein carboxylesterase NOTUM",".",".",".",".","pfam03283","PAE","Pectinacetylesterase.","GO:0030178|negative regulation of Wnt signaling pathway;GO:0030500|regulation of bone mineralization;GO:0060348|bone development;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:1990697|protein depalmitoleylation;",".","GO:0016298|lipase activity;GO:1990699|palmitoleyl hydrolase activity;","K19882","NOTUM; O-palmitoleoyl-L-serine hydrolase [EC:3.1.1.98]"]
["ENSRNOG00000007139",6,0.498159963,21,1.350939202,0.368750838,-1.439281766,0.017640773,0.013135779,"down","yes","Ttpa","protein_coding","chr5:33497137-33518073:+","gi|672052158|ref|XP_008761810.1|",1510,0,"PREDICTED: alpha-tocopherol transfer protein isoform X1 [Rattus norvegicus]","gi|672052157|ref|XM_008763588.1|",2121,0,"PREDICTED: Rattus norvegicus tocopherol (alpha) transfer protein (Ttpa), transcript variant X1, mRNA","P41034",439,{"v":6e-147,"d":"6.00E-147"},"Alpha-tocopherol transfer protein",".",".",".",".","pfam00650","CRAL_TRIO","CRAL/TRIO domain.","GO:0001890|placenta development;GO:0001892|embryonic placenta development;GO:0007584|response to nutrient;GO:0009268|response to pH;GO:0009636|response to toxic substance;GO:0032502|developmental process;GO:0042360|vitamin E metabolic process;GO:0051180|vitamin transport;GO:0051452|intracellular pH reduction;GO:0060548|negative regulation of cell death;GO:0090212|negative regulation of establishment of blood-brain barrier;GO:0120009|intermembrane lipid transfer;GO:1900223|positive regulation of amyloid-beta clearance;","GO:0005770|late endosome;GO:0005829|cytosol;","GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0008431|vitamin E binding;GO:0019842|vitamin binding;GO:0043325|phosphatidylinositol-3,4-bisphosphate binding;GO:0120013|intermembrane lipid transfer activity;GO:1902936|phosphatidylinositol bisphosphate binding;","K24455","TTPA; alpha-tocopherol transfer protein"]
["ENSRNOG00000023299",6,0.498159963,21,1.350939202,0.368750838,-1.439281766,0.017640773,0.013135779,"down","yes","Hfm1","protein_coding","chr14:2856599-2939238:+","gi|300797867|ref|NP_001178030.1|",7586,0,"probable ATP-dependent DNA helicase HFM1 [Rattus norvegicus]","gi|300797866|ref|NM_001191101.1|",4305,0,"Rattus norvegicus HFM1, ATP-dependent DNA helicase homolog (Hfm1), mRNA","D3Z4R1",2587,0,"Probable ATP-dependent DNA helicase HFM1","YGL251c",440,{"v":4e-130,"d":"4.00E-130"},"COG1204","pfam02889","Sec63","Sec63 Brl domain. This domain (also known as the Brl domain) is required for assembly of functional endoplasmic reticulum translocons.","GO:0000712|resolution of meiotic recombination intermediates;GO:0032508|DNA duplex unwinding;","GO:0005634|nucleus;","GO:0003676|nucleic acid binding;GO:0003678|DNA helicase activity;GO:0005524|ATP binding;","K15271","HFM1, MER3; ATP-dependent DNA helicase HFM1/MER3 [EC:5.6.2.4]"]
["ENSRNOG00000065697",6,0.498159963,21,1.350939202,0.368750838,-1.439281766,0.017640773,0.013135779,"down","yes","ENSRNOG00000065697","lncRNA","chr9:105805421-105816652:-","gi|149029743|gb|EDL84900.1|",161,{"v":3e-12,"d":"3.00E-12"},"rCG21031, partial [Rattus norvegicus]","gi|564370085|ref|XR_357299.1|",356,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102554935 (LOC102554935), ncRNA",".",".",".",".",".",".",".",".","pfam00383","dCMP_cyt_deam_1","Cytidine and deoxycytidylate deaminase zinc-binding region.",".",".",".",".","."]
["ENSRNOG00000005402",10,0.830266605,29,1.865582707,0.445044115,-1.167979744,0.017693955,0.013167712,"down","yes","AABR07040938.1","pseudogene","chrX:107587670-107590262:+","gi|149024815|gb|EDL81312.1|",2144,0,"rCG30717, isoform CRA_a [Rattus norvegicus]","gi|672054881|ref|XM_006239528.2|",2134,0,"PREDICTED: Rattus norvegicus cyclin-dependent kinase 11B (Cdk11b), transcript variant X2, mRNA","P24788",808,0,"Cyclin-dependent kinase 11B",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.",".",".",".",".","."]
["ENSRNOG00000012819",10,0.830266605,29,1.865582707,0.445044115,-1.167979744,0.017693955,0.013167712,"down","yes","Gdnf","protein_coding","chr2:56895010-56917209:+","gi|149016476|gb|EDL75694.1|",1114,{"v":7e-152,"d":"7.00E-152"},"glial cell line derived neurotrophic factor, isoform CRA_b [Rattus norvegicus]","gi|672041535|ref|XM_006232010.2|",735,0,"PREDICTED: Rattus norvegicus glial cell derived neurotrophic factor (Gdnf), transcript variant X4, mRNA","Q07731",374,{"v":3e-130,"d":"3.00E-130"},"Glial cell line-derived neurotrophic factor",".",".",".",".","pfam00019","TGF_beta","Transforming growth factor beta like domain.","GO:0001656|metanephros development;GO:0001657|ureteric bud development;GO:0001658|branching involved in ureteric bud morphogenesis;GO:0001755|neural crest cell migration;GO:0001759|organ induction;GO:0001941|postsynaptic membrane organization;GO:0003337|mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0007165|signal transduction;GO:0007399|nervous system development;GO:0007422|peripheral nervous system development;GO:0008283|cell proliferation;GO:0008284|positive regulation of cell proliferation;GO:0008584|male gonad development;GO:0009611|response to wounding;GO:0010468|regulation of gene expression;GO:0021516|dorsal spinal cord development;GO:0021784|postganglionic parasympathetic fiber development;GO:0030182|neuron differentiation;GO:0030432|peristalsis;GO:0030901|midbrain development;GO:0031175|neuron projection development;GO:0032770|positive regulation of monooxygenase activity;GO:0043524|negative regulation of neuron apoptotic process;GO:0045597|positive regulation of cell differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048255|mRNA stabilization;GO:0048484|enteric nervous system development;GO:0048485|sympathetic nervous system development;GO:0048568|embryonic organ development;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0051584|regulation of dopamine uptake involved in synaptic transmission;GO:0060041|retina development in camera-type eye;GO:0060676|ureteric bud formation;GO:0060688|regulation of morphogenesis of a branching structure;GO:0071549|cellular response to dexamethasone stimulus;GO:0071679|commissural neuron axon guidance;GO:0072106|regulation of ureteric bud formation;GO:0072107|positive regulation of ureteric bud formation;GO:0072108|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0090190|positive regulation of branching involved in ureteric bud morphogenesis;GO:2001240|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:2001260|regulation of semaphorin-plexin signaling pathway;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005794|Golgi apparatus;GO:0043235|receptor complex;","GO:0008083|growth factor activity;GO:0030116|glial cell-derived neurotrophic factor receptor binding;GO:0030971|receptor tyrosine kinase binding;GO:0042803|protein homodimerization activity;GO:0048018|receptor ligand activity;","K05452","GDNF; glial cell derived neurotrophic factor"]
["ENSRNOG00000025502",10,0.830266605,29,1.865582707,0.445044115,-1.167979744,0.017693955,0.013167712,"down","yes","Arhgef37","protein_coding","chr18:54949110-55000669:-","gi|564393678|ref|XP_006254869.1|",3438,0,"PREDICTED: rho guanine nucleotide exchange factor 37 isoform X1 [Rattus norvegicus]","gi|155369300|ref|NM_001100974.1|",4457,0,"Rattus norvegicus Rho guanine nucleotide exchange factor 37 (Arhgef37), mRNA","A1IGU3",1323,0,"Rho guanine nucleotide exchange factor 37",".",".",".",".","pfam03114","BAR","BAR domain. BAR domains are dimerization, lipid binding and curvature sensing modules found in many different protein families. A BAR domain with an additional N-terminal amphipathic helix (an N-BAR) can drive membrane curvature. These N-BAR domains are found in amphiphysin, endophilin, BRAP and Nadrin. BAR domains are also frequently found alongside domains that determine lipid specificity, like pfam00169 and pfam00787 domains in beta centaurins and sorting nexins respectively.","GO:0050790|regulation of catalytic activity;","GO:0005737|cytoplasm;","GO:0005085|guanyl-nucleotide exchange factor activity;","K20710","ARHGEF37; Rho guanine nucleotide exchange factor 37"]
["ENSRNOG00000047682",10,0.830266605,29,1.865582707,0.445044115,-1.167979744,0.017693955,0.013167712,"down","yes","AABR07065031.1","protein_coding","chr6:101256172-101265662:-","gi|672020940|ref|XP_008774512.1|",3897,0,"PREDICTED: disintegrin and metalloproteinase domain-containing protein 21 [Rattus norvegicus]","gi|672056892|ref|XM_008764883.1|",2623,0,"PREDICTED: Rattus norvegicus disintegrin and metalloproteinase domain-containing protein 21-like (LOC103690152), mRNA","Q9JI76",1303,0,"Disintegrin and metalloproteinase domain-containing protein 21",".",".",".",".","pfam01421","Reprolysin","Reprolysin (M12B) family zinc metalloprotease. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as human ADAM8 and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.",".",".",".",".","."]
["ENSRNOG00000011107",7,0.581186624,23,1.479600078,0.392799806,-1.348133878,0.018114779,0.013451141,"down","yes","Pcsk1","protein_coding","chr2:4395543-4442434:+","gi|8393919|ref|NP_058787.1|",3995,0,"neuroendocrine convertase 1 precursor [Rattus norvegicus]","gi|77695924|ref|NM_017091.2|",5046,0,"Rattus norvegicus proprotein convertase subtilisin/kexin type 1 (Pcsk1), mRNA","P28840",1543,0,"Neuroendocrine convertase 1","YNL238w_1",301,{"v":1e-88,"d":"1.00E-88"},"COG1404","pfam00082","Peptidase_S8","Subtilase family. Subtilases are a family of serine proteases. They appear to have independently and convergently evolved an Asp/Ser/His catalytic triad, like that found in the trypsin serine proteases (see pfam00089). Structure is an alpha/beta fold containing a 7-stranded parallel beta sheet, order 2314567.","GO:0006508|proteolysis;GO:0009410|response to xenobiotic stimulus;GO:0009749|response to glucose;GO:0010035|response to inorganic substance;GO:0010157|response to chlorate;GO:0014070|response to organic cyclic compound;GO:0016485|protein processing;GO:0016486|peptide hormone processing;GO:0016540|protein autoprocessing;GO:0021983|pituitary gland development;GO:0022008|neurogenesis;GO:0031016|pancreas development;GO:0031667|response to nutrient levels;GO:0032496|response to lipopolysaccharide;GO:0043043|peptide biosynthetic process;GO:0043278|response to morphine;GO:0043434|response to peptide hormone;GO:0048678|response to axon injury;GO:0050714|positive regulation of protein secretion;GO:0051384|response to glucocorticoid;GO:0051592|response to calcium ion;GO:0070542|response to fatty acid;GO:0070555|response to interleukin-1;","GO:0005615|extracellular space;GO:0005791|rough endoplasmic reticulum;GO:0005802|trans-Golgi network;GO:0016020|membrane;GO:0030133|transport vesicle;GO:0030141|secretory granule;GO:0030425|dendrite;GO:0034774|secretory granule lumen;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0043679|axon terminus;GO:0048471|perinuclear region of cytoplasm;","GO:0004175|endopeptidase activity;GO:0004252|serine-type endopeptidase activity;GO:0042802|identical protein binding;","K01359","PCSK1; proprotein convertase subtilisin/kexin type 1 [EC:3.4.21.93]"]
["ENSRNOG00000064376",7,0.581186624,23,1.479600078,0.392799806,-1.348133878,0.018114779,0.013451141,"down","yes","RGD1562660","protein_coding","chr19:22509598-22514258:+","gi|564323679|ref|XP_006227195.1|",1140,{"v":9e-155,"d":"9.00E-155"},"PREDICTED: uncharacterized protein LOC367516 [Rattus norvegicus]","gi|672033535|ref|XM_006227133.2|",853,0,"PREDICTED: Rattus norvegicus hypothetical LOC367516 (LOC367516), mRNA",".",".",".",".",".",".",".",".","pfam04822","Takusan","Takusan. This domain is named takusan, which is a Japanese word meaning 'many'. Members of this family regulate synaptic activity.",".",".",".",".","."]
["ENSRNOG00000067892",7,0.581186624,23,1.479600078,0.392799806,-1.348133878,0.018114779,0.013451141,"down","yes","ENSRNOG00000067892","lncRNA","chr1:205619205-205622461:+","gi|149062285|gb|EDM12708.1|",267,{"v":2e-26,"d":"2.00E-26"},"rCG47316, isoform CRA_d [Rattus norvegicus]","gi|766944340|ref|NR_131096.1|",568,0,"Rattus norvegicus uncharacterized LOC100912041 (LOC100912041), long non-coding RNA",".",".",".",".",".",".",".",".","pfam11046","HycA_repressor","Transcriptional repressor of hyc and hyp operons. This family is conserved in Proteobacteria. It is likely to be the transcriptional repressor molecule for the hyc and hyp operons, which express, amongst others, the protein HycA. This protein may be harnessed for the reduction of technetium oxide, an unwelcome product of radio-nucleotide bioaccumulation. HycA produces formate hydrogenlyase, one of the key proteins necessary for metal compound reduction.",".",".",".",".","."]
["ENSRNOG00000011334",8,0.664213284,25,1.608260955,0.413000939,-1.275783034,0.018222782,0.013509375,"down","yes","Tmem63c","protein_coding","chr6:106672934-106736990:+","gi|157820653|ref|NP_001101515.1|",4016,0,"calcium permeable stress-gated cation channel 1 [Rattus norvegicus]","gi|157820652|ref|NM_001108045.1|",3604,0,"Rattus norvegicus transmembrane protein 63c (Tmem63c), mRNA","Q8CBX0",1454,0,"Calcium permeable stress-gated cation channel 1","SPAC24H6.13",55.5,1e-06,"COG5594","pfam02714","DUF221","Domain of unknown function DUF221. This family consists of hypothetical transmembrane proteins none of which have any function, the aligned region is at 538 residues at maximum length.","GO:0003094|glomerular filtration;GO:0006812|cation transport;GO:0098655|cation transmembrane transport;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0005227|calcium activated cation channel activity;GO:1990760|osmolarity-sensing cation channel activity;","K21989","TMEM63, CSC1; calcium permeable stress-gated cation channel"]
["ENSRNOG00000067225",8,0.664213284,25,1.608260955,0.413000939,-1.275783034,0.018222782,0.013509375,"down","yes","ENSRNOG00000067225","lncRNA","chr12:16472828-16473949:+","gi|148698707|gb|EDL30654.1|",130,2e-06,"mCG146276, partial [Mus musculus]","gi|672072421|ref|XR_595276.1|",86,{"v":5e-35,"d":"5.00E-35"},"PREDICTED: Rattus norvegicus uncharacterized LOC102554019 (LOC102554019), transcript variant X2, ncRNA","P11369",52.8,4e-06,"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam13610","DDE_Tnp_IS240","DDE domain. This DDE domain is found in a wide variety of transposases including those found in IS240, IS26, IS6100 and IS26.",".",".",".",".","."]
["ENSRNOG00000011518",3,0.249079982,14,0.900626135,0.276563129,-1.854319265,0.020173348,0.014780621,"down","yes","Dusp26","protein_coding","chr16:61041792-61049051:-","gi|640815631|ref|XP_008064591.1|",973,{"v":8e-126,"d":"8.00E-126"},"PREDICTED: dual specificity protein phosphatase 26 [Tarsius syrichta]","gi|59891426|ref|NM_001012352.1|",1599,0,"Rattus norvegicus dual specificity phosphatase 26 (putative) (Dusp26), mRNA","Q5FVI9",368,{"v":1e-123,"d":"1.00E-123"},"Dual specificity protein phosphatase 26","SPBC17A3.06",63.2,{"v":5e-10,"d":"5.00E-10"},"COG2453","pfam00782","DSPc","Dual specificity phosphatase, catalytic domain. Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a \"recognition\" region.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006470|protein dephosphorylation;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0043409|negative regulation of MAPK cascade;GO:0044387|negative regulation of protein kinase activity by regulation of protein phosphorylation;GO:0045785|positive regulation of cell adhesion;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:1902310|positive regulation of peptidyl-serine dephosphorylation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;","GO:0002039|p53 binding;GO:0004721|phosphoprotein phosphatase activity;GO:0004725|protein tyrosine phosphatase activity;GO:0008138|protein tyrosine/serine/threonine phosphatase activity;GO:0033549|MAP kinase phosphatase activity;GO:0036424|L-phosphoserine phosphatase activity;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;","K14165","K14165; atypical dual specificity phosphatase [EC:3.1.3.16 3.1.3.48]"]
["ENSRNOG00000015401",3,0.249079982,14,0.900626135,0.276563129,-1.854319265,0.020173348,0.014780621,"down","yes","Mapk4","protein_coding","chr18:67512807-67661842:-","gi|402794629|ref|NP_062192.1|",3015,0,"mitogen-activated protein kinase 4 [Rattus norvegicus]","gi|672083546|ref|XM_008772166.1|",4545,0,"PREDICTED: Rattus norvegicus mitogen-activated protein kinase 4 (Mapk4), transcript variant X1, mRNA","Q6P5G0",1152,0,"Mitogen-activated protein kinase 4",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0000165|MAPK cascade;GO:0006468|protein phosphorylation;GO:0035556|intracellular signal transduction;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0004674|protein serine/threonine kinase activity;GO:0004707|MAP kinase activity;GO:0005524|ATP binding;GO:0019901|protein kinase binding;GO:0042803|protein homodimerization activity;GO:0046982|protein heterodimerization activity;","K06855","MAPK4_6; mitogen-activated protein kinase 4/6 [EC:2.7.11.24]"]
["ENSRNOG00000016894",3,0.249079982,14,0.900626135,0.276563129,-1.854319265,0.020173348,0.014780621,"down","yes","Dnd1","protein_coding","chr18:28378692-28381316:-","gi|157820299|ref|NP_001102849.1|",1523,0,"dead end protein homolog 1 [Rattus norvegicus]","gi|157820298|ref|NM_001109379.1|",1517,0,"Rattus norvegicus DND microRNA-mediated repression inhibitor 1 (Dnd1), mRNA","Q6VY05",573,0,"Dead end protein homolog 1",".",".",".",".","pfam14709","DND1_DSRM","double strand RNA binding domain from DEAD END PROTEIN 1. A C-terminal domain in human dead end protein 1 (DND1_HUMAN) homologous to double strand RNA binding domains (PF00035, PF00333)","GO:0007281|germ cell development;GO:0007283|spermatogenesis;GO:0048255|mRNA stabilization;GO:0060965|negative regulation of gene silencing by miRNA;GO:0061158|3'-UTR-mediated mRNA destabilization;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005739|mitochondrion;","GO:0003723|RNA binding;GO:0003729|mRNA binding;GO:0003730|mRNA 3'-UTR binding;","K24981","DND1; dead end 1"]
["ENSRNOG00000002911",0,0.04151333,7,0.450313067,0.09218771,-3.439281766,0.0206111,0.015037599,"down","yes","Alb","protein_coding","chr14:17607381-17622836:-","gi|158138568|ref|NP_599153.2|",3178,0,"serum albumin precursor [Rattus norvegicus]","gi|158138567|ref|NM_134326.2|",1801,0,"Rattus norvegicus albumin (Alb), mRNA","P02770",1227,0,"Serum albumin",".",".",".",".","pfam00273","Serum_albumin","Serum albumin family.","GO:0001895|retina homeostasis;GO:0006810|transport;GO:0007584|response to nutrient;GO:0009267|cellular response to starvation;GO:0010033|response to organic substance;GO:0042311|vasodilation;GO:0043066|negative regulation of apoptotic process;GO:0046010|positive regulation of circadian sleep/wake cycle, non-REM sleep;GO:0046689|response to mercury ion;GO:0051659|maintenance of mitochondrion location;GO:0070541|response to platinum ion;","GO:0005576|extracellular region;GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0032991|protein-containing complex;GO:0070062|extracellular exosome;","GO:0003677|DNA binding;GO:0005504|fatty acid binding;GO:0008270|zinc ion binding;GO:0015643|toxic substance binding;GO:0019825|oxygen binding;GO:0019899|enzyme binding;GO:0030170|pyridoxal phosphate binding;GO:0036094|small molecule binding;GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0051087|chaperone binding;GO:0072341|modified amino acid binding;GO:1903981|enterobactin binding;","K16141","ALB; serum albumin"]
["ENSRNOG00000004443",0,0.04151333,7,0.450313067,0.09218771,-3.439281766,0.0206111,0.015037599,"down","yes","Sptlc3","protein_coding","chr3:126847878-126978010:+","gi|157817891|ref|NP_001099987.1|",2923,0,"serine palmitoyltransferase 3 [Rattus norvegicus]","gi|157817890|ref|NM_001106517.1|",2837,0,"Rattus norvegicus serine palmitoyltransferase, long chain base subunit 3 (Sptlc3), mRNA","Q8BG54",991,0,"Serine palmitoyltransferase 3","YDR062w",399,{"v":4e-126,"d":"4.00E-126"},"COG0156","pfam00155","Aminotran_1_2","Aminotransferase class I and II.","GO:0008150|biological_process;GO:0046512|sphingosine biosynthetic process;GO:0046513|ceramide biosynthetic process;GO:0046520|sphingoid biosynthetic process;","GO:0005575|cellular_component;GO:0016021|integral component of membrane;GO:0017059|serine C-palmitoyltransferase complex;","GO:0003674|molecular_function;GO:0004758|serine C-palmitoyltransferase activity;GO:0008483|transaminase activity;GO:0030170|pyridoxal phosphate binding;","K00654","SPT; serine palmitoyltransferase [EC:2.3.1.50]"]
["ENSRNOG00000004928",0,0.04151333,7,0.450313067,0.09218771,-3.439281766,0.0206111,0.015037599,"down","yes","Sntg2","protein_coding","chr6:46801377-47003372:-","gi|564355593|ref|XP_006240029.1|",2738,0,"PREDICTED: gamma-2-syntrophin isoform X1 [Rattus norvegicus]","gi|568977790|ref|XM_006515109.1|",1878,0,"PREDICTED: Mus musculus syntrophin, gamma 2 (Sntg2), transcript variant X2, mRNA","Q925E0",1018,0,"Gamma-2-syntrophin",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.",".","GO:0005622|intracellular;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0016010|dystrophin-associated glycoprotein complex;","GO:0005198|structural molecule activity;GO:0030165|PDZ domain binding;GO:0097109|neuroligin family protein binding;","K24065","SNTG; gamma-syntrophin"]
["ENSRNOG00000008592",0,0.04151333,7,0.450313067,0.09218771,-3.439281766,0.0206111,0.015037599,"down","yes","Barx2","protein_coding","chr8:30251132-30319013:-","gi|392341840|ref|XP_003754445.1|",1203,{"v":2e-157,"d":"2.00E-157"},"PREDICTED: homeobox protein BarH-like 2 [Rattus norvegicus]","gi|672022652|ref|XM_003754397.3|",1828,0,"PREDICTED: Rattus norvegicus BARX homeobox 2 (Barx2), mRNA","O08686",448,{"v":1e-151,"d":"1.00E-151"},"Homeobox protein BarH-like 2",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001502|cartilage condensation;GO:0006357|regulation of transcription by RNA polymerase II;GO:0014902|myotube differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0015629|actin cytoskeleton;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003700|DNA-binding transcription factor activity;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09361","BARX; BarH-like homeobox"]
["ENSRNOG00000011671",0,0.04151333,7,0.450313067,0.09218771,-3.439281766,0.0206111,0.015037599,"down","yes","ENSRNOG00000011671","protein_coding","chr19:28669059-28704508:+","gi|71043912|ref|NP_001020935.1|",833,{"v":9e-106,"d":"9.00E-106"},"uncharacterized protein C4orf51 homolog [Rattus norvegicus]","gi|71043911|ref|NM_001025764.1|",1519,0,"Rattus norvegicus LOC498933 (LOC498933), mRNA",".",".",".",".",".",".",".",".","pfam03363","Herpes_LP","Herpesvirus leader protein.",".",".",".",".","."]
["ENSRNOG00000012450",0,0.04151333,7,0.450313067,0.09218771,-3.439281766,0.0206111,0.015037599,"down","yes","Dynlrb2","protein_coding","chr19:44520134-44531387:+","gi|25072207|ref|NP_083573.1|",428,{"v":4e-48,"d":"4.00E-48"},"dynein light chain roadblock-type 2 [Mus musculus]","gi|62945691|gb|AC112969.12|",655,0,"Mus musculus chromosome 8, clone RP24-331K7, complete sequence","Q9DAJ5",169,{"v":1e-49,"d":"1.00E-49"},"Dynein light chain roadblock-type 2",".",".",".",".","pfam03259","Robl_LC7","Roadblock/LC7 domain. This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.","GO:0007018|microtubule-based movement;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0005868|cytoplasmic dynein complex;GO:0005874|microtubule;","GO:0003674|molecular_function;GO:0045505|dynein intermediate chain binding;","K10419","DYNLRB, DNCL2; dynein light chain roadblock-type"]
["ENSRNOG00000013932",0,0.04151333,7,0.450313067,0.09218771,-3.439281766,0.0206111,0.015037599,"down","yes","Rbp2","protein_coding","chr8:99079104-99104473:+","gi|344244364|gb|EGW00468.1|",729,{"v":5e-92,"d":"5.00E-92"},"Retinol-binding protein 2 [Cricetulus griseus]","gi|564365074|ref|XM_006243607.1|",725,0,"PREDICTED: Rattus norvegicus retinol binding protein 2, cellular (Rbp2), transcript variant X1, mRNA","P06768",275,{"v":5e-92,"d":"5.00E-92"},"Retinol-binding protein 2",".",".",".",".","pfam00061","Lipocalin","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.","GO:0042572|retinol metabolic process;","GO:0005829|cytosol;","GO:0016918|retinal binding;GO:0019841|retinol binding;","K14622","RBP2, CRBP2; retinol binding protein 2"]
["ENSRNOG00000015321",0,0.04151333,7,0.450313067,0.09218771,-3.439281766,0.0206111,0.015037599,"down","yes","Moxd1","protein_coding","chr1:21075122-21161779:-","gi|293343514|ref|XP_001054130.2|",3225,0,"PREDICTED: DBH-like monooxygenase protein 1 [Rattus norvegicus]","gi|672012545|ref|XM_001054130.4|",3048,0,"PREDICTED: Rattus norvegicus monooxygenase, DBH-like 1 (Moxd1), mRNA","Q9CXI3",1169,0,"DBH-like monooxygenase protein 1",".",".",".",".","pfam01082","Cu2_monooxygen","Copper type II ascorbate-dependent monooxygenase, N-terminal domain. The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.","GO:0006589|octopamine biosynthetic process;GO:0042420|dopamine catabolic process;GO:0042421|norepinephrine biosynthetic process;","GO:0005615|extracellular space;GO:0005789|endoplasmic reticulum membrane;GO:0030667|secretory granule membrane;","GO:0004500|dopamine beta-monooxygenase activity;GO:0005507|copper ion binding;",".","."]
["ENSRNOG00000015448",0,0.04151333,7,0.450313067,0.09218771,-3.439281766,0.0206111,0.015037599,"down","yes","Dipk1c","protein_coding","chr18:78087991-78109904:+","gi|62664711|ref|XP_574179.1|",1825,0,"PREDICTED: protein FAM69C [Rattus norvegicus]","gi|672030959|ref|XM_001061354.5|",2045,0,"PREDICTED: Rattus norvegicus family with sequence similarity 69, member C (Fam69c), mRNA","Q8BQT2",671,0,"Protein FAM69C",".",".",".",".","pfam12260","PIP49_C","Protein-kinase domain of FAM69. This is the C-terminal region of a family of FAM69 proteins from Metazoa and Viridiplantae that are active protein-kinases. The family members have a short transmembrane helix close to the N-terminus, and thereafter are highly enriched with cysteines. FAM69 proteins are localized to the endoplasmic reticulum. Many members also have a short EF-hand, calcium-binding, domain just upstream of the kinase domain. The exact function of the more N-terminal family is uncertain.",".","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000024709",0,0.04151333,7,0.450313067,0.09218771,-3.439281766,0.0206111,0.015037599,"down","yes","Vwde","protein_coding","chr4:41455281-41533374:-","gi|672018235|ref|XP_008773934.1|",9152,0,"PREDICTED: von Willebrand factor D and EGF domain-containing protein [Rattus norvegicus]","gi|672018234|ref|XM_008775712.1|",5292,0,"PREDICTED: Rattus norvegicus von Willebrand factor D and EGF domains (Vwde), mRNA","Q8N2E2",1796,0,"von Willebrand factor D and EGF domain-containing protein",".",".",".",".","pfam00094","VWD","von Willebrand factor type D domain. Luciferin-2-monooxygenase from Vargula hilgendorfii contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.",".",".",".",".","."]
["ENSRNOG00000032827",0,0.04151333,7,0.450313067,0.09218771,-3.439281766,0.0206111,0.015037599,"down","yes","AABR07058412.1","protein_coding","chr7:105662744-105730060:-","gi|672021972|ref|XP_008774707.1|",6644,0,"PREDICTED: maestro heat-like repeat family member 5 isoform X4 [Rattus norvegicus]","gi|672021971|ref|XM_008776485.1|",3883,0,"PREDICTED: Rattus norvegicus maestro heat-like repeat family member 5 (Mroh5), transcript variant X4, mRNA",".",".",".",".",".",".",".",".","pfam15449","Retinal","Retinal protein. This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.",".",".",".",".","."]
["ENSRNOG00000037221",0,0.04151333,7,0.450313067,0.09218771,-3.439281766,0.0206111,0.015037599,"down","yes","Tipinl1","protein_coding","chr9:113543173-113605998:-","gi|293361862|ref|XP_002730112.1|",1176,{"v":1E-155,"d":"1.00E-155"},"PREDICTED: TIMELESS-interacting protein [Rattus norvegicus]","gi|672033025|ref|XM_003754721.3|",884,0,"PREDICTED: Rattus norvegicus TIMELESS interacting protein like 1 (Tipinl1), mRNA","Q4QR88",456,{"v":1E-156,"d":"1.00E-156"},"TIMELESS-interacting protein",".",".",".",".","pfam07962","Swi3","Replication Fork Protection Component Swi3. Replication fork pausing is required to initiate a recombination events. More specifically, Swi1 is required for recombination near the mat1 locus. Swi3 has been found to co-purify with Swi1 Swi3, together with Swi1, define a fork protection complex that coordinates leading- and lagging-strand synthesis and stabilizes stalled replication forks. The Swi1-Swi3 complex is required for accurate replication, fork protection and replication checkpoint signalling","GO:0000076|DNA replication checkpoint;GO:0006974|cellular response to DNA damage stimulus;GO:0043111|replication fork arrest;GO:0048478|replication fork protection;","GO:0031298|replication fork protection complex;","GO:0003677|DNA binding;","K10904","TIPIN; TIMELESS-interacting protein"]
["ENSRNOG00000050121",0,0.04151333,7,0.450313067,0.09218771,-3.439281766,0.0206111,0.015037599,"down","yes","Rhag","protein_coding","chr9:20069807-20097836:-","gi|149069231|gb|EDM18672.1|",2029,0,"Rhesus blood group-associated A glycoprotein [Rattus norvegicus]","gi|40254762|ref|NM_023022.2|",2126,0,"Rattus norvegicus Rh-associated glycoprotein (Rhag), mRNA","Q7TNK7",783,0,"Ammonium transporter Rh type A","sll1017",64.3,{"v":5e-10,"d":"5.00E-10"},"COG0004","pfam00909","Ammonium_transp","Ammonium Transporter Family.","GO:0006873|cellular ion homeostasis;GO:0008150|biological_process;GO:0015670|carbon dioxide transport;GO:0015696|ammonium transport;GO:0048821|erythrocyte development;GO:0060586|multicellular organismal iron ion homeostasis;GO:0072488|ammonium transmembrane transport;GO:0098662|inorganic cation transmembrane transport;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;","GO:0003674|molecular_function;GO:0008519|ammonium transmembrane transporter activity;GO:0022840|leak channel activity;GO:0030506|ankyrin binding;","K06580","SLC42A, RHAG, RHBG, RHCG, CD241; ammonium transporter Rh"]
["ENSRNOG00000063029",0,0.04151333,7,0.450313067,0.09218771,-3.439281766,0.0206111,0.015037599,"down","yes","ENSRNOG00000063029","lncRNA","chr1:193753396-193759800:+",".",".",".",".","gi|672038915|ref|XM_008760004.1|",581,0,"PREDICTED: Rattus norvegicus janus kinase and microtubule interacting protein 3 (Jakmip3), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam07142","DUF1388","Repeat of unknown function (DUF1388). This family consists of several repeats of around 29 residues in length. Members of this family are found in the variable surface lipoproteins in Mycoplasma bovis and in mammalian neurofilament triplet H (NefH or NF-H) proteins. This repeat contains several Lys-Ser-Pro (KSP) motifs and in NefH these are thought to function as the main target for neurofilament directed protein kinases in vivo.",".",".",".",".","."]
["ENSRNOG00000063049",0,0.04151333,7,0.450313067,0.09218771,-3.439281766,0.0206111,0.015037599,"down","yes","Pnma8c","protein_coding","chr1:77669078-77673858:+","gi|755520312|ref|XP_011249051.1|",843,{"v":4e-100,"d":"4.00E-100"},"PREDICTED: paraneoplastic antigen Ma2 homolog [Mus musculus]","gi|189164076|gb|AC118918.5|",4781,0,"Rattus norvegicus BAC CH230-334O19 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam14893","PNMA","PNMA. The PNMA family includes paraneoplastic antigens Ma 1, 2 and 3, found in the serum of patients with paraneoplastic neurological disorders. The family also includes modulator of apoptosis 1, which has a role in death receptor-dependent apoptosis.",".",".",".",".","."]
["ENSRNOG00000063719",0,0.04151333,7,0.450313067,0.09218771,-3.439281766,0.0206111,0.015037599,"down","yes","ENSRNOG00000063719","lncRNA","chr5:145798064-145800053:-",".",".",".",".","gi|672019997|ref|XM_001065500.4|",302,{"v":8e-155,"d":"8.00E-155"},"PREDICTED: Rattus norvegicus G patch domain containing 3 (Gpatch3), mRNA",".",".",".",".",".",".",".",".","pfam09381","Porin_OmpG","Outer membrane protein G (OmpG). Porins are channel proteins in the outer membrane of gram negative bacteria which mediate the uptake of molecules required for growth and survival. Escherichia coli OmpG forms a 14 stranded beta-barrel and in contrast to most porins, appears to function as a monomer. The central pore of OmpG is wider than other Escherichia coli porins and it is speculated that it may form a non-specific channel for the transport of larger oligosaccharides.",".",".",".",".","."]
["ENSRNOG00000063726",0,0.04151333,7,0.450313067,0.09218771,-3.439281766,0.0206111,0.015037599,"down","yes","Zfp42l","protein_coding","chr4:157334760-157345452:+","gi|564349006|ref|XP_006237450.1|",1577,0,"PREDICTED: zinc finger protein 42-like isoform X2 [Rattus norvegicus]","gi|672051090|ref|XM_006237388.2|",1763,0,"PREDICTED: Rattus norvegicus Zinc finger protein 42-like (Zfp42l), transcript variant X2, mRNA","P22227",448,{"v":1e-140,"d":"1.00E-140"},"Zinc finger protein 42",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.",".",".",".",".","."]
["ENSRNOG00000065024",0,0.04151333,7,0.450313067,0.09218771,-3.439281766,0.0206111,0.015037599,"down","yes","ENSRNOG00000065024","lncRNA","chr13:22303663-22308294:-","gi|149037240|gb|EDL91740.1|",131,4e-07,"rCG24047 [Rattus norvegicus]","gi|27261694|gb|AC124710.4|",213,{"v":1e-105,"d":"1.00E-105"},"Mus musculus BAC clone RP24-92A2 from chromosome 1, complete sequence",".",".",".",".",".",".",".",".","pfam06760","DUF1221","Protein of unknown function (DUF1221). This is a family of plant proteins, most of which are hypothetical and of unknown function. All members contain the pfam00069 domain, suggesting that they may possess kinase activity.",".",".",".",".","."]
["ENSRNOG00000067792",0,0.04151333,7,0.450313067,0.09218771,-3.439281766,0.0206111,0.015037599,"down","yes","ENSRNOG00000067792","protein_coding","chr1:238567690-238602876:-","gi|26337919|dbj|BAC32645.1|",558,{"v":4e-62,"d":"4.00E-62"},"unnamed protein product [Mus musculus]","gi|260441710|gb|AC120070.6|",2690,0,"Rattus norvegicus BAC CH230-481C18 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q64458",103,{"v":2e-21,"d":"2.00E-21"},"Cytochrome P450 2C29",".",".",".",".","pfam02337","Gag_p10","Retroviral GAG p10 protein. This family consists of various retroviral GAG (core) polyproteins and encompasses the p10 region producing the p10 protein upon proteolytic cleavage of GAG by retroviral protease. The p10 or matrix protein (MA) is associated with the virus envelope glycoproteins in most mammalian retroviruses and may be involved in virus particle assembly, transport and budding. Some of the GAG polyproteins have alternate cleavage sites leading to the production of alternative and longer cleavage products (e.g. p19) the alignment of this family only covers the approximately N-terminal (GAG) 100 amino acid region of homology to p10.",".",".",".",".","."]
["ENSRNOG00000068491",0,0.04151333,7,0.450313067,0.09218771,-3.439281766,0.0206111,0.015037599,"down","yes","ENSRNOG00000068491","processed_pseudogene","chrX:75549216-75549455:-","gi|635030032|ref|XP_007980173.1|",422,{"v":8e-50,"d":"8.00E-50"},"PREDICTED: 40S ribosomal protein S2 isoform X2 [Chlorocebus sabaeus]","gi|2920832|gb|U92700.1|RNU92700",234,{"v":5e-118,"d":"5.00E-118"},"Rattus norvegicus ribosomal protein S2 mRNA, complete cds","P27952",162,{"v":5e-49,"d":"5.00E-49"},"40S ribosomal protein S2","SPCC576.08c",77,{"v":1e-17,"d":"1.00E-17"},"COG0098","pfam03719","Ribosomal_S5_C","Ribosomal protein S5, C-terminal domain.",".",".",".",".","."]
["ENSRNOG00000017147",13,1.079346587,34,2.187234898,0.493475387,-1.018949967,0.021492237,0.015614419,"down","yes","Trim6","protein_coding","chr1:158683746-158696914:+","gi|281604214|ref|NP_001163932.1|",2508,0,"tripartite motif-containing protein 6 [Rattus norvegicus]","gi|281604213|ref|NM_001170461.1|",2430,0,"Rattus norvegicus tripartite motif containing 6 (Trim6), mRNA","Q8BGE7",913,0,"Tripartite motif-containing protein 6",".",".",".",".","pfam00622","SPRY","SPRY domain. SPRY Domain is named from SPla and the RYanodine Receptor. Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.","GO:0000209|protein polyubiquitination;GO:0002230|positive regulation of defense response to virus by host;GO:0002720|positive regulation of cytokine production involved in immune response;GO:0008150|biological_process;GO:0010468|regulation of gene expression;GO:0010508|positive regulation of autophagy;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010800|positive regulation of peptidyl-threonine phosphorylation;GO:0010994|free ubiquitin chain polymerization;GO:0016567|protein ubiquitination;GO:0032496|response to lipopolysaccharide;GO:0032880|regulation of protein localization;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0035458|cellular response to interferon-beta;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0045892|negative regulation of transcription, DNA-templated;GO:0046596|regulation of viral entry into host cell;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0060340|positive regulation of type I interferon-mediated signaling pathway;GO:0098586|cellular response to virus;GO:2000679|positive regulation of transcription regulatory region DNA binding;GO:2000737|negative regulation of stem cell differentiation;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0003674|molecular_function;GO:0008270|zinc ion binding;GO:0019901|protein kinase binding;GO:0030674|protein binding, bridging;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0061630|ubiquitin protein ligase activity;GO:1990782|protein tyrosine kinase binding;","K11999","TRIM6_22_34; tripartite motif-containing protein 6/22/34"]
["ENSRNOG00000015408",4,0.332106642,16,1.029287011,0.322656983,-1.631926844,0.023114974,0.016588052,"down","yes","Vil1","protein_coding","chr9:75991141-76018858:+","gi|157817658|ref|NP_001101694.1|",4268,0,"villin-1 [Rattus norvegicus]","gi|197927351|ref|NM_001108224.2|",3301,0,"Rattus norvegicus villin 1 (Vil1), mRNA","Q62468",1593,0,"Villin-1",".",".",".",".","pfam00626","Gelsolin","Gelsolin repeat.","GO:0001951|intestinal D-glucose absorption;GO:0006915|apoptotic process;GO:0007173|epidermal growth factor receptor signaling pathway;GO:0008150|biological_process;GO:0008154|actin polymerization or depolymerization;GO:0008360|regulation of cell shape;GO:0009617|response to bacterium;GO:0010634|positive regulation of epithelial cell migration;GO:0030041|actin filament polymerization;GO:0030042|actin filament depolymerization;GO:0030335|positive regulation of cell migration;GO:0030836|positive regulation of actin filament depolymerization;GO:0030855|epithelial cell differentiation;GO:0032233|positive regulation of actin filament bundle assembly;GO:0032532|regulation of microvillus length;GO:0035729|cellular response to hepatocyte growth factor stimulus;GO:0040018|positive regulation of multicellular organism growth;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045010|actin nucleation;GO:0051014|actin filament severing;GO:0051016|barbed-end actin filament capping;GO:0051125|regulation of actin nucleation;GO:0051693|actin filament capping;GO:0060327|cytoplasmic actin-based contraction involved in cell motility;GO:0061041|regulation of wound healing;GO:0071364|cellular response to epidermal growth factor stimulus;GO:1902896|terminal web assembly;GO:1903078|positive regulation of protein localization to plasma membrane;GO:2000392|regulation of lamellipodium morphogenesis;GO:2000394|positive regulation of lamellipodium morphogenesis;","GO:0001726|ruffle;GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005902|microvillus;GO:0005903|brush border;GO:0015629|actin cytoskeleton;GO:0030027|lamellipodium;GO:0030175|filopodium;GO:0032432|actin filament bundle;GO:0032433|filopodium tip;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0035727|lysophosphatidic acid binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0043027|cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0051015|actin filament binding;","K05761","VIL1; villin 1"]
["ENSRNOG00000020028",4,0.332106642,16,1.029287011,0.322656983,-1.631926844,0.023114974,0.016588052,"down","yes","Pcdhb22","protein_coding","chr18:29223149-29225536:+","gi|109506501|ref|XP_001056235.1|",4032,0,"PREDICTED: protocadherin beta-15 [Rattus norvegicus]","gi|672083183|ref|XM_001056235.5|",2388,0,"PREDICTED: Rattus norvegicus protocadherin beta 22 (Pcdhb22), transcript variant X2, mRNA","Q9Y5E8",1155,0,"Protocadherin beta-15",".",".",".",".","pfam08266","Cadherin_2","Cadherin-like. This cadherin domain is usually the most N-terminal copy of the domain.","GO:0007155|cell adhesion;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;","GO:0005887|integral component of plasma membrane;GO:0032391|photoreceptor connecting cilium;","GO:0005509|calcium ion binding;",".","."]
["ENSRNOG00000020062",4,0.332106642,16,1.029287011,0.322656983,-1.631926844,0.023114974,0.016588052,"down","yes","Pcdhb6l","protein_coding","chr18:29146313-29148703:+","gi|149017300|gb|EDL76351.1|",3942,0,"rCG49357 [Rattus norvegicus]","gi|86440007|gb|AC096374.7|",2391,0,"Rattus norvegicus BAC CH230-17K7 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q9Y5E3",1144,0,"Protocadherin beta-6",".",".",".",".","pfam08266","Cadherin_2","Cadherin-like. This cadherin domain is usually the most N-terminal copy of the domain.","GO:0007155|cell adhesion;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;","GO:0005887|integral component of plasma membrane;","GO:0005509|calcium ion binding;","K16494","PCDHB; protocadherin beta"]
["ENSRNOG00000038169",4,0.332106642,16,1.029287011,0.322656983,-1.631926844,0.023114974,0.016588052,"down","yes","AABR07038930.1","protein_coding","chrX:59891581-59892330:-","gi|672032375|ref|XP_008756666.1|",1166,{"v":2E-159,"d":"2.00E-159"},"PREDICTED: spindlin-4 [Rattus norvegicus]","gi|672032374|ref|XM_008758444.1|",750,0,"PREDICTED: Rattus norvegicus spindlin family, member 4 (Spin4), mRNA","Q8K1L2",451,{"v":3E-160,"d":"3.00E-160"},"Spindlin-4",".",".",".",".","pfam02513","Spin-Ssty","Spin/Ssty Family. Spindlin (Spin) is a novel maternal transcript present in the unfertilised egg and early embryo. The Y-linked spermiogenesis -specific transcript (Ssty) is also expressed during gametogenesis and forms part of this Pfam family. Members of this family contain three copies of this 50 residue repeat. The repeat is predicted to contain four beta strands.",".",".",".",".","."]
["ENSRNOG00000004438",5,0.415133303,18,1.157947887,0.358507759,-1.47992375,0.02488239,0.017715241,"down","yes","Cntn1","protein_coding","chr7:123372792-123558541:+","gi|16923964|ref|NP_476459.1|",5243,0,"contactin-1 precursor [Rattus norvegicus]","gi|402744779|ref|NM_057118.2|",3204,0,"Rattus norvegicus contactin 1 (Cntn1), mRNA","Q63198",2023,0,"Contactin-1",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0007155|cell adhesion;GO:0007219|Notch signaling pathway;GO:0010628|positive regulation of gene expression;GO:0010765|positive regulation of sodium ion transport;GO:0010976|positive regulation of neuron projection development;GO:0021549|cerebellum development;GO:0031175|neuron projection development;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;","GO:0005886|plasma membrane;GO:0045121|membrane raft;GO:0099025|anchored component of postsynaptic membrane;GO:0099026|anchored component of presynaptic membrane;","GO:0005515|protein binding;GO:0030246|carbohydrate binding;","K06759","CNTN1; contactin 1"]
["ENSRNOG00000012609",5,0.415133303,18,1.157947887,0.358507759,-1.47992375,0.02488239,0.017715241,"down","yes","Trdn","protein_coding","chr1:23955651-24410595:-","gi|149032864|gb|EDL87719.1|",1014,{"v":3e-120,"d":"3.00E-120"},"triadin, isoform CRA_d [Rattus norvegicus]","gi|31340608|ref|NM_021666.2|",4147,0,"Rattus norvegicus triadin (Trdn), mRNA","Q9QX75",386,{"v":8E-116,"d":"8.00E-116"},"Triadin",".",".",".",".","pfam05279","Asp-B-Hydro_N","Aspartyl beta-hydroxylase N-terminal region. This family includes the N-terminal regions of the junctin, junctate and aspartyl beta-hydroxylase proteins. Junctate is an integral ER/SR membrane calcium binding protein, which comes from an alternatively spliced form of the same gene that generates aspartyl beta-hydroxylase and junctin. Aspartyl beta-hydroxylase catalyses the post-translational hydroxylation of aspartic acid or asparagine residues contained within epidermal growth factor (EGF) domains of proteins.","GO:0006874|cellular calcium ion homeostasis;GO:0009617|response to bacterium;GO:0010880|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0014070|response to organic cyclic compound;GO:0014808|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0014902|myotube differentiation;GO:0031122|cytoplasmic microtubule organization;GO:0051280|negative regulation of release of sequestered calcium ion into cytosol;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;GO:0060047|heart contraction;GO:0060316|positive regulation of ryanodine-sensitive calcium-release channel activity;GO:0086036|regulation of cardiac muscle cell membrane potential;GO:0090158|endoplasmic reticulum membrane organization;GO:1901846|positive regulation of cell communication by electrical coupling involved in cardiac conduction;","GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0014701|junctional sarcoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0016529|sarcoplasmic reticulum;GO:0030314|junctional membrane complex;GO:0033017|sarcoplasmic reticulum membrane;GO:0034704|calcium channel complex;GO:0042383|sarcolemma;GO:0043231|intracellular membrane-bounded organelle;","GO:0005102|signaling receptor binding;GO:0005515|protein binding;GO:0030674|protein binding, bridging;GO:0044325|ion channel binding;","K23449","TRDN; triadin"]
["ENSRNOG00000056434",5,0.415133303,18,1.157947887,0.358507759,-1.47992375,0.02488239,0.017715241,"down","yes","Gm25663","snoRNA","chr13:55522359-55522493:+",".",".",".",".","gi|564380983|ref|XR_358970.1|",135,{"v":3e-63,"d":"3.00E-63"},"PREDICTED: Rattus norvegicus uncharacterized LOC102549528 (LOC102549528), ncRNA",".",".",".",".",".",".",".",".","pfam10143","PhosphMutase","2,3-bisphosphoglycerate-independent phosphoglycerate mutase. Members of this family are found in various bacterial 2,3-bisphosphoglycerate-independent phosphoglycerate mutase enzymes, which catalyse the interconversion of 2-phosphoglycerate and 3-phosphoglycerate in the reaction: [2-phospho-D-glycerate + 2,3-diphosphoglycerate = 3-phospho-D-glycerate + 2,3-diphosphoglycerate].",".",".",".",".","."]
["ENSRNOG00000065330",5,0.415133303,18,1.157947887,0.358507759,-1.47992375,0.02488239,0.017715241,"down","yes","Mrgpre","protein_coding","chr1:198963787-198969521:-","gi|50511332|ref|NP_001002288.1|",1296,{"v":7e-165,"d":"7.00E-165"},"mas-related G-protein coupled receptor member E [Rattus norvegicus]","gi|672039458|ref|XM_008760163.1|",3398,0,"PREDICTED: Rattus norvegicus MAS-related GPR, member E (Mrgpre), transcript variant X2, mRNA","Q7TN40",503,{"v":2e-166,"d":"2.00E-166"},"Mas-related G-protein coupled receptor member E",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.",".",".",".",".","."]
["ENSRNOG00000002031",9,0.747239945,26,1.672591393,0.446755823,-1.162441561,0.025258803,0.017963231,"down","yes","Naa11","protein_coding","chr14:12183651-12193686:+","gi|67078532|ref|NP_001019913.1|",1324,{"v":1e-171,"d":"1.00E-171"},"N-alpha-acetyltransferase 11 [Rattus norvegicus]","gi|67078531|ref|NM_001024742.1|",3229,0,"Rattus norvegicus N(alpha)-acetyltransferase 11, NatA catalytic subunit (Naa11), mRNA","Q4V8K3",514,{"v":3e-173,"d":"3.00E-173"},"N-alpha-acetyltransferase 11","SPAC15E1.08",220,{"v":8e-65,"d":"8.00E-65"},"COG0456","pfam00583","Acetyltransf_1","Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.","GO:0006474|N-terminal protein amino acid acetylation;GO:0017198|N-terminal peptidyl-serine acetylation;GO:0018002|N-terminal peptidyl-glutamic acid acetylation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005794|Golgi apparatus;GO:0005813|centrosome;GO:0005829|cytosol;GO:0031415|NatA complex;","GO:0004596|peptide alpha-N-acetyltransferase activity;GO:1990189|peptide-serine-N-acetyltransferase activity;GO:1990190|peptide-glutamate-N-acetyltransferase activity;","K20791","NAA10_11, ARD1_2; N-alpha-acetyltransferase 10/11 [EC:2.3.1.255]"]
["ENSRNOG00000067701",6,0.498159963,20,1.286608764,0.38718838,-1.368892438,0.025770486,0.018284417,"down","yes","ENSRNOG00000067701","lncRNA","chr4:161398170-161446081:-",".",".",".",".","gi|41237737|gb|AC119177.11|",334,{"v":2e-172,"d":"2.00E-172"},"Mus musculus chromosome 15, clone RP24-559L16, complete sequence",".",".",".",".",".",".",".",".","pfam05675","DUF817","Protein of unknown function (DUF817). This family consists of several bacterial proteins of unknown function.",".",".",".",".","."]
["ENSRNOG00000069420",6,0.498159963,20,1.286608764,0.38718838,-1.368892438,0.025770486,0.018284417,"down","yes","Sh2d1b2","protein_coding","chr13:82437428-82461509:+","gi|293352845|ref|XP_001065477.2|",605,{"v":9e-69,"d":"9.00E-69"},"PREDICTED: SH2 domain-containing protein 1B-like [Rattus norvegicus]","gi|672027330|ref|XM_003752656.3|",4394,0,"PREDICTED: Rattus norvegicus SH2 domain protein 1B2 (Sh2d1b2), mRNA","Q45HK4",196,{"v":6e-56,"d":"6.00E-56"},"SH2 domain-containing protein 1B2",".",".",".",".","pfam00017","SH2","SH2 domain.",".",".",".",".","."]
["ENSRNOG00000002525",8,0.664213284,24,1.543930516,0.430209311,-1.216889345,0.025800581,0.018295738,"down","yes","Ptgs2","protein_coding","chr13:62163932-62172188:+","gi|148747270|ref|NP_058928.3|",3077,0,"prostaglandin G/H synthase 2 precursor [Rattus norvegicus]","gi|7110562|gb|AF233596.1|AF233596",4200,0,"Rattus norvegicus cyclooxygenase-2 mRNA, complete cds","P35355",1188,0,"Prostaglandin G/H synthase 2",".",".",".",".","pfam03098","An_peroxidase","Animal haem peroxidase.","GO:0001516|prostaglandin biosynthetic process;GO:0001525|angiogenesis;GO:0006954|inflammatory response;GO:0006979|response to oxidative stress;GO:0007566|embryo implantation;GO:0007568|aging;GO:0007612|learning;GO:0007613|memory;GO:0008217|regulation of blood pressure;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0009314|response to radiation;GO:0009410|response to xenobiotic stimulus;GO:0009750|response to fructose;GO:0010033|response to organic substance;GO:0010042|response to manganese ion;GO:0010226|response to lithium ion;GO:0010243|response to organonitrogen compound;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0010942|positive regulation of cell death;GO:0014070|response to organic cyclic compound;GO:0019233|sensory perception of pain;GO:0019371|cyclooxygenase pathway;GO:0030282|bone mineralization;GO:0030728|ovulation;GO:0031394|positive regulation of prostaglandin biosynthetic process;GO:0031622|positive regulation of fever generation;GO:0031915|positive regulation of synaptic plasticity;GO:0032227|negative regulation of synaptic transmission, dopaminergic;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0033280|response to vitamin D;GO:0034097|response to cytokine;GO:0034605|cellular response to heat;GO:0034612|response to tumor necrosis factor;GO:0034644|cellular response to UV;GO:0035633|maintenance of permeability of blood-brain barrier;GO:0042127|regulation of cell proliferation;GO:0042307|positive regulation of protein import into nucleus;GO:0042633|hair cycle;GO:0043065|positive regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0045786|negative regulation of cell cycle;GO:0045907|positive regulation of vasoconstriction;GO:0045986|negative regulation of smooth muscle contraction;GO:0045987|positive regulation of smooth muscle contraction;GO:0046697|decidualization;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0050873|brown fat cell differentiation;GO:0051384|response to glucocorticoid;GO:0051926|negative regulation of calcium ion transport;GO:0051968|positive regulation of synaptic transmission, glutamatergic;GO:0070542|response to fatty acid;GO:0071260|cellular response to mechanical stimulus;GO:0071284|cellular response to lead ion;GO:0071318|cellular response to ATP;GO:0071456|cellular response to hypoxia;GO:0071471|cellular response to non-ionic osmotic stress;GO:0071498|cellular response to fluid shear stress;GO:0071636|positive regulation of transforming growth factor beta production;GO:0090050|positive regulation of cell migration involved in sprouting angiogenesis;GO:0090271|positive regulation of fibroblast growth factor production;GO:0090336|positive regulation of brown fat cell differentiation;GO:0090362|positive regulation of platelet-derived growth factor production;GO:0098869|cellular oxidant detoxification;GO:0150077|regulation of neuroinflammatory response;GO:1902219|negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress;GO:1990776|response to angiotensin;","GO:0005637|nuclear inner membrane;GO:0005640|nuclear outer membrane;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005901|caveola;GO:0032991|protein-containing complex;GO:0043005|neuron projection;","GO:0004601|peroxidase activity;GO:0004666|prostaglandin-endoperoxide synthase activity;GO:0005515|protein binding;GO:0016702|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;GO:0019899|enzyme binding;GO:0020037|heme binding;GO:0042803|protein homodimerization activity;GO:0046872|metal ion binding;","K11987","PTGS2, COX2; prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]"]
["ENSRNOG00000011453",2,0.166053321,11,0.70763482,0.234659624,-2.091358462,0.025815055,0.018295738,"down","yes","Kif6","protein_coding","chr9:11072824-11373006:-","gi|564311103|ref|XP_006226768.1|",4108,0,"PREDICTED: kinesin-like protein KIF6 [Rattus norvegicus]","gi|564311102|ref|XM_006226706.1|",3349,0,"PREDICTED: Rattus norvegicus kinesin family member 6 (Kif6), mRNA","Q6ZMV9",1281,0,"Kinesin-like protein KIF6","SPAC1834.07",221,{"v":1e-60,"d":"1.00E-60"},"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0007018|microtubule-based movement;GO:0007286|spermatid development;","GO:0001673|male germ cell nucleus;GO:0005871|kinesin complex;GO:0005874|microtubule;","GO:0003777|microtubule motor activity;GO:0005524|ATP binding;GO:0008017|microtubule binding;GO:0016887|ATPase activity;","K10397","KIF6_9; kinesin family member 6/9"]
["ENSRNOG00000013085",2,0.166053321,11,0.70763482,0.234659624,-2.091358462,0.025815055,0.018295738,"down","yes","Nkain3","protein_coding","chr5:33623713-34309381:-","gi|157817666|ref|NP_001103010.1|",956,{"v":4E-125,"d":"4.00E-125"},"sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3 precursor [Rattus norvegicus]","gi|157817665|ref|NM_001109540.1|",1428,0,"Rattus norvegicus Na+/K+ transporting ATPase interacting 3 (Nkain3), mRNA","Q3URJ8",369,{"v":2E-125,"d":"2.00E-125"},"Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3",".",".",".",".","pfam05640","NKAIN","Na,K-Atpase Interacting protein. NKAIN (Na,K-Atpase INteracting) proteins are a family of evolutionary conserved transmembrane proteins that localize to neurons, that are critical for neuronal function, and that interact with the beta subunits, beta1 in vertebrates and beta in Drosophila, of Na,K-ATPase. NKAINs have highly conserved trans-membrane domains but otherwise no other characterized domains. NKAINs may function as subunits of pore or channel structures in neurons or they may affect the function of other membrane proteins. They are likely to function within the membrane bilayer.","GO:0002028|regulation of sodium ion transport;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;",".","K22735","NKAIN; sodium/potassium-transporting ATPase subunit beta-1-interacting protein"]
["ENSRNOG00000020621",2,0.166053321,11,0.70763482,0.234659624,-2.091358462,0.025815055,0.018295738,"down","yes","Dcst1","protein_coding","chr2:174765350-174781806:-","gi|672043230|ref|XP_008759465.1|",3687,0,"PREDICTED: DC-STAMP domain-containing protein 1 [Rattus norvegicus]","gi|672043229|ref|XM_008761243.1|",2324,0,"PREDICTED: Rattus norvegicus DC-STAMP domain containing 1 (Dcst1), mRNA","Q059Y8",1121,0,"E3 ubiquitin-protein ligase DCST1",".",".",".",".","pfam07782","DC_STAMP","DC-STAMP-like protein. This is a family of sequences which are similar to a region of the dendritic cell-specific transmembrane protein (DC-STAMP). This is thought to be a novel receptor protein that shares no identity with other multimembrane-spanning proteins. It is thought to have seven putative transmembrane regions, two of which are found in the region featured in this family. DC-STAMP is also described as having potential N-linked glycosylation sites and a potential phosphorylation site for PKC, but these are not conserved throughout the family.","GO:0006511|ubiquitin-dependent protein catabolic process;GO:0016567|protein ubiquitination;GO:0060339|negative regulation of type I interferon-mediated signaling pathway;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;","K22375","DCST1; E3 ubiquitin-protein ligase DCST1 [EC:2.3.2.27]"]
["ENSRNOG00000030243",2,0.166053321,11,0.70763482,0.234659624,-2.091358462,0.025815055,0.018295738,"down","yes","Lrp1b","protein_coding","chr3:24594991-26715505:-","gi|153792247|ref|NP_443737.2|",22681,0,"low-density lipoprotein receptor-related protein 1B precursor [Mus musculus]","gi|153792246|ref|NM_053011.2|",12360,0,"Mus musculus low density lipoprotein-related protein 1B (deleted in tumors) (Lrp1b), mRNA","Q9JI18",8739,0,"Low-density lipoprotein receptor-related protein 1B",".",".",".",".","pfam00057","Ldl_recept_a","Low-density lipoprotein receptor domain class A.",".",".",".",".","."]
["ENSRNOG00000036882",2,0.166053321,11,0.70763482,0.234659624,-2.091358462,0.025815055,0.018295738,"down","yes","Fbxo47","protein_coding","chr10:82849730-82879538:-","gi|672069264|ref|XP_008766423.1|",2385,0,"PREDICTED: LOW QUALITY PROTEIN: F-box only protein 47 isoform X2 [Rattus norvegicus]","gi|672069263|ref|XM_008768201.1|",1457,0,"PREDICTED: Rattus norvegicus F-box protein 47 (Fbxo47), transcript variant X2, mRNA","A2A6H3",883,0,"F-box only protein 47",".",".",".",".","pfam00646","F-box","F-box domain. This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.",".",".",".","K10321","FBXO47; F-box protein 47"]
["ENSRNOG00000051590",2,0.166053321,11,0.70763482,0.234659624,-2.091358462,0.025815055,0.018295738,"down","yes","ENSRNOG00000051590","protein_coding","chr14:97493658-97496679:-","gi|157818849|ref|NP_001103052.1|",963,{"v":3e-128,"d":"3.00E-128"},"uncharacterized protein C2orf74 homolog [Rattus norvegicus]","gi|157818848|ref|NM_001109582.1|",976,0,"Rattus norvegicus hypothetical protein LOC690352 (LOC690352), mRNA","Q810S2",245,{"v":1E-78,"d":"1.00E-78"},"Uncharacterized protein C2orf74 homolog",".",".",".",".","pfam15484","DUF4642","Domain of unknown function (DUF4642). This family of proteins is found in eukaryotes. Proteins in this family are typically between 115 and 196 amino acids in length.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000054444",2,0.166053321,11,0.70763482,0.234659624,-2.091358462,0.025815055,0.018295738,"down","yes","RNaseP_nuc","ribozyme","chr20:46304592-46305062:-",".",".",".",".","gi|49615144|gb|AC094571.8|",471,0,"Rattus norvegicus 20 BAC CH230-4L21 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam15351","JCAD","Junctional protein associated with coronary artery disease. JCAD is a component of VE-cadherin-based cell-cell junctions in endothelial cells. The cell-cell or adherens junction is an adhesion complex that plays a crucial role in the organisation and function of epithelial and endothelial cellular sheets. These junctions join the actin cytoskeleton to the plasma membrane to form adhesive contacts between cells or between cells and extracellular matrix. The junctions also mediate both cell adhesion and cell-signalling. JCAD localizes close to the apical membrane in epithelial cells. This family is found in eukaryotes.",".",".",".",".","."]
["ENSRNOG00000062547",2,0.166053321,11,0.70763482,0.234659624,-2.091358462,0.025815055,0.018295738,"down","yes","ENSRNOG00000062547","protein_coding","chr3:5529038-5580167:+","gi|148694633|gb|EDL26580.1|",397,{"v":2e-44,"d":"2.00E-44"},"Cd99 antigen-like 2, isoform CRA_c [Mus musculus]","gi|672042599|ref|XM_008761070.1|",350,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103691573 (LOC103691573), transcript variant X2, mRNA","Q8R1R5",149,{"v":2e-42,"d":"2.00E-42"},"CD99 antigen-like protein 2",".",".",".",".","pfam12301","CD99L2","CD99 antigen like protein 2. This family of proteins is found in eukaryotes. Proteins in this family are typically between 165 and 237 amino acids in length. CD99L2 and CD99 are involved in trans-endothelial migration of neutrophils in vitro and in the recruitment of neutrophils into inflamed peritoneum.",".",".",".",".","."]
["ENSRNOG00000069446",2,0.166053321,11,0.70763482,0.234659624,-2.091358462,0.025815055,0.018295738,"down","yes","ENSRNOG00000069446","protein_coding","chr1:224814100-224831928:-","gi|148709700|gb|EDL41646.1|",416,{"v":3e-44,"d":"3.00E-44"},"very low density lipoprotein receptor, isoform CRA_b, partial [Mus musculus]","gi|672040053|ref|XM_006231199.2|",276,{"v":5e-141,"d":"5.00E-141"},"PREDICTED: Rattus norvegicus very low density lipoprotein receptor (Vldlr), transcript variant X3, mRNA","P98166",155,{"v":1E-42,"d":"1.00E-42"},"Very low-density lipoprotein receptor",".",".",".",".","pfam00057","Ldl_recept_a","Low-density lipoprotein receptor domain class A.",".",".",".",".","."]
["ENSRNOG00000017546",7,0.581186624,22,1.41526964,0.410654343,-1.28400354,0.026016271,0.018417929,"down","yes","Mylk3","protein_coding","chr19:21691929-21742954:+","gi|408407655|sp|E9PT87.1|MYLK3_RAT",3720,0,"RecName: Full=Myosin light chain kinase 3; AltName: Full=Cardiac-MyBP-C-associated Ca/CaM kinase; Short=Cardiac-MLCK","gi|160961484|ref|NM_001110810.1|",2402,0,"Rattus norvegicus myosin light chain kinase 3 (Mylk3), mRNA","E9PT87",1437,0,"Myosin light chain kinase 3",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0002528|regulation of vascular permeability involved in acute inflammatory response;GO:0006468|protein phosphorylation;GO:0045214|sarcomere organization;GO:0048769|sarcomerogenesis;GO:0055003|cardiac myofibril assembly;GO:0060298|positive regulation of sarcomere organization;GO:0071347|cellular response to interleukin-1;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0015629|actin cytoskeleton;","GO:0004683|calmodulin-dependent protein kinase activity;GO:0004687|myosin light chain kinase activity;GO:0005524|ATP binding;","K00907","MYLK; myosin-light-chain kinase [EC:2.7.11.18]"]
["ENSRNOG00000053586",7,0.581186624,22,1.41526964,0.410654343,-1.28400354,0.026016271,0.018417929,"down","yes","Snord19","snoRNA","chr16:6210838-6210914:-",".",".",".",".","gi|908663642|tpe|LN872820.1|",64,{"v":4e-24,"d":"4.00E-24"},"TPA: Mus musculus SNORD19 gene for small nucleolar RNA SNORD19",".",".",".",".",".",".",".",".","pfam11360","DUF3110","Protein of unknown function (DUF3110). This family of proteins has no known function.",".",".",".",".","."]
["ENSRNOG00000007031",1,0.083026661,8,0.514643505,0.161328492,-2.631926844,0.029383284,0.020488524,"down","yes","Trim9","protein_coding","chr6:88757303-88856542:-","gi|556522611|ref|NP_001273317.1|",4109,0,"E3 ubiquitin-protein ligase TRIM9 isoform f [Mus musculus]","gi|672056250|ref|XM_008764691.1|",3977,0,"PREDICTED: Rattus norvegicus tripartite motif-containing 9 (Trim9), transcript variant X1, mRNA","Q8C7M3",1549,0,"E3 ubiquitin-protein ligase TRIM9",".",".",".",".","pfam00622","SPRY","SPRY domain. SPRY Domain is named from SPla and the RYanodine Receptor. Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.","GO:0016079|synaptic vesicle exocytosis;GO:0016567|protein ubiquitination;GO:0035544|negative regulation of SNARE complex assembly;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045955|negative regulation of calcium ion-dependent exocytosis;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0008021|synaptic vesicle;GO:0030425|dendrite;GO:0099523|presynaptic cytosol;","GO:0000149|SNARE binding;GO:0008270|zinc ion binding;GO:0019904|protein domain specific binding;GO:0042803|protein homodimerization activity;GO:0061630|ubiquitin protein ligase activity;","K10649","TRIM9_67; tripartite motif-containing protein 9/67"]
["ENSRNOG00000011649",1,0.083026661,8,0.514643505,0.161328492,-2.631926844,0.029383284,0.020488524,"down","yes","Epb42","protein_coding","chr3:107979713-107997932:-","gi|157819871|ref|NP_001102060.1|",3708,0,"erythrocyte membrane protein band 4.2 [Rattus norvegicus]","gi|197927360|ref|NM_001108590.2|",2544,0,"Rattus norvegicus erythrocyte membrane protein band 4.2 (Epb42), mRNA","P49222",1282,0,"Erythrocyte membrane protein band 4.2",".",".",".",".","pfam00868","Transglut_N","Transglutaminase family.","GO:0000902|cell morphogenesis;GO:0008150|biological_process;GO:0018149|peptide cross-linking;GO:0020027|hemoglobin metabolic process;GO:0048536|spleen development;GO:0050801|ion homeostasis;GO:0055072|iron ion homeostasis;","GO:0005575|cellular_component;GO:0016020|membrane;GO:0030863|cortical cytoskeleton;","GO:0003674|molecular_function;GO:0003810|protein-glutamine gamma-glutamyltransferase activity;","K25094","EPB42; erythrocyte membrane protein band 4.2"]
["ENSRNOG00000015101",1,0.083026661,8,0.514643505,0.161328492,-2.631926844,0.029383284,0.020488524,"down","yes","Mak","protein_coding","chr17:23693878-23730001:+","gi|380865394|sp|P20793.2|MAK_RAT",3188,0,"RecName: Full=Serine/threonine-protein kinase MAK; AltName: Full=Male germ cell-associated kinase","gi|755544685|ref|XM_006516868.2|",1851,0,"PREDICTED: Mus musculus male germ cell-associated kinase (Mak), transcript variant X1, mRNA","P20793",1232,0,"Serine/threonine-protein kinase MAK",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006468|protein phosphorylation;GO:0007283|spermatogenesis;GO:0030154|cell differentiation;GO:0035556|intracellular signal transduction;GO:0042073|intraciliary transport;GO:0045494|photoreceptor cell maintenance;GO:0045893|positive regulation of transcription, DNA-templated;GO:0046777|protein autophosphorylation;GO:0060271|cilium assembly;GO:1902856|negative regulation of non-motile cilium assembly;","GO:0001750|photoreceptor outer segment;GO:0001917|photoreceptor inner segment;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0005929|cilium;GO:0005930|axoneme;GO:0030496|midbody;GO:0031514|motile cilium;GO:0032391|photoreceptor connecting cilium;GO:0072686|mitotic spindle;GO:0097542|ciliary tip;","GO:0003713|transcription coactivator activity;GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;GO:0046872|metal ion binding;","K08829","MAK; male germ cell-associated kinase [EC:2.7.11.22]"]
["ENSRNOG00000021745",1,0.083026661,8,0.514643505,0.161328492,-2.631926844,0.029383284,0.020488524,"down","yes","Bhlhe22","protein_coding","chr2:100486400-100489510:+","gi|157822033|ref|NP_001102410.1|",1160,{"v":4e-146,"d":"4.00E-146"},"class E basic helix-loop-helix protein 22 [Rattus norvegicus]","gi|157822032|ref|NM_001108940.1|",3106,0,"Rattus norvegicus basic helix-loop-helix family, member e22 (Bhlhe22), mRNA","Q8C6A8",437,{"v":2e-142,"d":"2.00E-142"},"Class E basic helix-loop-helix protein 22",".",".",".",".","pfam00010","HLH","Helix-loop-helix DNA-binding domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0021540|corpus callosum morphogenesis;GO:0021796|cerebral cortex regionalization;GO:0021952|central nervous system projection neuron axonogenesis;GO:0021957|corticospinal tract morphogenesis;GO:0021960|anterior commissure morphogenesis;GO:0030182|neuron differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0060040|retinal bipolar neuron differentiation;GO:0060042|retina morphogenesis in camera-type eye;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003682|chromatin binding;GO:0042802|identical protein binding;GO:0046983|protein dimerization activity;GO:1990837|sequence-specific double-stranded DNA binding;","K09086","BHLHB4_5, BETA; class B basic helix-loop-helix protein 4/5"]
["ENSRNOG00000024245",1,0.083026661,8,0.514643505,0.161328492,-2.631926844,0.029383284,0.020488524,"down","yes","Zkscan2","protein_coding","chr1:178009238-178028131:-","gi|109459369|ref|XP_001079250.1|",4831,0,"PREDICTED: zinc finger protein with KRAB and SCAN domains 2 [Rattus norvegicus]","gi|672038302|ref|XM_001079250.5|",3655,0,"PREDICTED: Rattus norvegicus zinc finger with KRAB and SCAN domains 2 (Zkscan2), transcript variant X1, mRNA","Q63HK3",1506,0,"Zinc finger protein with KRAB and SCAN domains 2",".",".",".",".","pfam02023","SCAN","SCAN domain. The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerization.","GO:0006357|regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0046872|metal ion binding;","K09229","ZKSCAN; KRAB and SCAN domains-containing zinc finger protein"]
["ENSRNOG00000027601",1,0.083026661,8,0.514643505,0.161328492,-2.631926844,0.029383284,0.020488524,"down","yes","Lhfpl1","protein_coding","chrX:108815596-108873460:-","gi|507550739|ref|XP_004659174.1|",1044,{"v":3e-139,"d":"3.00E-139"},"PREDICTED: lipoma HMGIC fusion partner-like 1 protein isoform X1 [Jaculus jaculus]","gi|31342032|ref|NM_181085.2|",1067,0,"Rattus norvegicus lipoma HMGIC fusion partner-like 1 (Lhfpl1), mRNA","Q80WE5",386,{"v":5e-133,"d":"5.00E-133"},"LHFPL tetraspan subfamily member 1 protein",".",".",".",".","pfam10242","L_HGMIC_fpl","Lipoma HMGIC fusion partner-like protein. This is a group of proteins expressed from a series of genes referred to as Lipoma HGMIC fusion partner-like. The proteins carry four highly conserved transmembrane domains in this entry. In certain instances, eg in LHFPL5, mutations cause deafness in humans and hypospadias, and LHFPL1 is transcribed in six liver tumor cell lines.",".","GO:0016020|membrane;GO:0016021|integral component of membrane;",".","K23893","LHFPL; LHFPL tetraspan subfamily member protein"]
["ENSRNOG00000027836",1,0.083026661,8,0.514643505,0.161328492,-2.631926844,0.029383284,0.020488524,"down","yes","Kcnmb3","protein_coding","chr2:115253761-115270142:-","gi|157151708|ref|NP_001098030.1|",1185,{"v":8e-158,"d":"8.00E-158"},"calcium-activated potassium channel subunit beta-3 [Rattus norvegicus]","gi|402744437|ref|NM_001104560.2|",1637,0,"Rattus norvegicus potassium calcium-activated channel subfamily M regulatory beta subunit 3 (Kcnmb3), mRNA","A7VL23",461,{"v":3e-159,"d":"3.00E-159"},"Calcium-activated potassium channel subunit beta-3",".",".",".",".","pfam03185","CaKB","Calcium-activated potassium channel, beta subunit.","GO:0001508|action potential;GO:0005513|detection of calcium ion;GO:0006813|potassium ion transport;GO:0019228|neuronal action potential;GO:0071805|potassium ion transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0008076|voltage-gated potassium channel complex;","GO:0015269|calcium-activated potassium channel activity;GO:0015459|potassium channel regulator activity;","K04939","KCNMB3; potassium large conductance calcium-activated channel subfamily M beta member 3"]
["ENSRNOG00000032871",1,0.083026661,8,0.514643505,0.161328492,-2.631926844,0.029383284,0.020488524,"down","yes","Mlc1","protein_coding","chr7:120046705-120067049:-","gi|157823887|ref|NP_001101575.1|",1886,0,"membrane protein MLC1 [Rattus norvegicus]","gi|157823886|ref|NM_001108105.1|",1736,0,"Rattus norvegicus megalencephalic leukoencephalopathy with subcortical cysts 1 (Mlc1), mRNA","Q8VHK5",667,0,"Membrane protein MLC1",".",".",".",".","pfam15282","BMP2K_C","BMP-2-inducible protein kinase C-terminus. This family represents the C-terminus of BMP2K and related proteins.","GO:0015031|protein transport;GO:0016192|vesicle-mediated transport;GO:0032388|positive regulation of intracellular transport;GO:0047484|regulation of response to osmotic stress;GO:0071397|cellular response to cholesterol;GO:0072584|caveolin-mediated endocytosis;","GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0005768|endosome;GO:0005769|early endosome;GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005901|caveola;GO:0005911|cell-cell junction;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0031410|cytoplasmic vesicle;GO:0045121|membrane raft;GO:0048471|perinuclear region of cytoplasm;GO:0055037|recycling endosome;GO:0097450|astrocyte end-foot;","GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;","K20070","MLC1; membrane protein MLC1"]
["ENSRNOG00000049295",1,0.083026661,8,0.514643505,0.161328492,-2.631926844,0.029383284,0.020488524,"down","yes","AABR07071891.3","protein_coding","chr1:83195271-83223764:-","gi|149056494|gb|EDM07925.1|",406,{"v":4e-45,"d":"4.00E-45"},"rCG54172, isoform CRA_a [Rattus norvegicus]","gi|47084435|gb|AC120085.5|",558,0,"Rattus norvegicus 10 BAC CH230-490B8 (Children's Hospital Oakland Research Institute) complete sequence","P16374",137,{"v":7e-34,"d":"7.00E-34"},"Zinc finger protein 60",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006355|regulation of transcription, DNA-templated;",".",".",".","."]
["ENSRNOG00000052723",1,0.083026661,8,0.514643505,0.161328492,-2.631926844,0.029383284,0.020488524,"down","yes","AABR07031154.1","snoRNA","chr18:1704945-1705053:-",".",".",".",".","gi|908662265|tpe|LN871987.1|",63,{"v":2e-23,"d":"2.00E-23"},"TPA: Mus musculus SNORA17 (ACA17) gene for small nucleolar RNA SNORA17 (ACA17)",".",".",".",".",".",".",".",".","pfam06317","Arena_RNA_pol","Arenavirus RNA polymerase. This family consists of several Arenavirus RNA polymerase proteins (EC:2.7.7.48).",".",".",".",".","."]
["ENSRNOG00000058449",1,0.083026661,8,0.514643505,0.161328492,-2.631926844,0.029383284,0.020488524,"down","yes","AC141169.3","snoRNA","chr9:64582070-64582201:+",".",".",".",".","gi|908663032|tpe|LN872437.1|",114,{"v":1E-51,"d":"1.00E-51"},"TPA: Mus musculus SNORA41 (ACA41) gene for small nucleolar RNA SNORA41 (ACA41)",".",".",".",".",".",".",".",".","pfam10272","Tmpp129","Putative transmembrane protein precursor. This is a family of proteins conserved from worms to humans. The proteins are purported to be transmembrane protein-precursors but the function is unknown.",".",".",".",".","."]
["ENSRNOG00000060407",1,0.083026661,8,0.514643505,0.161328492,-2.631926844,0.029383284,0.020488524,"down","yes","Cacna1i","protein_coding","chr7:111836012-111944688:+","gi|157057194|ref|NP_001037773.2|",8797,0,"voltage-dependent T-type calcium channel subunit alpha-1I [Mus musculus]","gi|113195658|ref|NM_020084.3|",6455,0,"Rattus norvegicus calcium voltage-gated channel subunit alpha1 I (Cacna1i), mRNA","Q9Z0Y8",3347,0,"Voltage-dependent T-type calcium channel subunit alpha-1I","BH1501",87,{"v":4e-17,"d":"4.00E-17"},"COG1226","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0006816|calcium ion transport;GO:0019228|neuronal action potential;GO:0030317|flagellated sperm motility;GO:0030431|sleep;GO:0034765|regulation of ion transmembrane transport;GO:0035725|sodium ion transmembrane transport;GO:0042391|regulation of membrane potential;GO:0045956|positive regulation of calcium ion-dependent exocytosis;GO:0060402|calcium ion transport into cytosol;GO:0070509|calcium ion import;GO:0070588|calcium ion transmembrane transport;GO:0086010|membrane depolarization during action potential;","GO:0001518|voltage-gated sodium channel complex;GO:0005891|voltage-gated calcium channel complex;GO:0043005|neuron projection;","GO:0005248|voltage-gated sodium channel activity;GO:0008332|low voltage-gated calcium channel activity;","K04856","CACNA1I, CAV3.3; voltage-dependent calcium channel T type alpha-1I"]
["ENSRNOG00000062824",1,0.083026661,8,0.514643505,0.161328492,-2.631926844,0.029383284,0.020488524,"down","yes","ENSRNOG00000062824","lncRNA","chr7:98397608-98399073:+",".",".",".",".","gi|77020467|gb|AC163443.6|",362,0,"Mus musculus chromosome 15, clone RP23-284G17, complete sequence",".",".",".",".",".",".",".",".","pfam03665","UPF0172","Uncharacterized protein family (UPF0172). In Chlamydomonas reinhardtii the protein TLA1 (truncated light-harvesting chlorophyll antenna size) apparently regulates genes that define the chlorophyll-a antenna size in the photosynthetic apparatus. This family was formerly known as UPF0172.",".",".",".",".","."]
["ENSRNOG00000063033",1,0.083026661,8,0.514643505,0.161328492,-2.631926844,0.029383284,0.020488524,"down","yes","ENSRNOG00000063033","lncRNA","chr15:98883429-98884679:+",".",".",".",".","gi|74218175|gb|AC165155.2|",582,0,"Mus musculus BAC clone RP23-293N22 from chromosome 14, complete sequence",".",".",".",".",".",".",".",".","pfam06952","PsiA","PsiA protein. This family consists of several Enterobacterial PsiA proteins. The function of PsiA is unknown although it is thought that it may affect the generation of an SOS signal in Escherichia coli.",".",".",".",".","."]
["ENSRNOG00000064793",1,0.083026661,8,0.514643505,0.161328492,-2.631926844,0.029383284,0.020488524,"down","yes","ENSRNOG00000064793","lncRNA","chr17:76130605-76133792:+",".",".",".",".","gi|672030289|ref|XR_598218.1|",795,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102548777 (LOC102548777), ncRNA",".",".",".",".",".",".",".",".","pfam14936","p53-inducible11","tumor protein p53-inducible protein 11. TP53 is a tumor suppressor gene, when switched on it suppresses tumor development by inducing stable growth arrest or cell apoptosis. The tumor protein TP53 inducible protein 11 encoded for by the gene TP53I11, has a protein sequence of 189 amino acids in length and 21 kDa in mass. The role of this protein is thought to negatively regulate cell proliferation in response to stress, and therefore suppress tumor formation.",".",".",".",".","."]
["ENSRNOG00000064824",1,0.083026661,8,0.514643505,0.161328492,-2.631926844,0.029383284,0.020488524,"down","yes","ENSRNOG00000064824","protein_coding","chr4:125510192-125670252:+","gi|45478126|gb|AAS66234.1|",737,{"v":9e-174,"d":"9.00E-174"},"LRRGT00143 [Rattus norvegicus]","gi|269847890|gb|AC120718.4|",864,0,"Rattus norvegicus BAC CH230-125I15 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P11369",265,{"v":4e-162,"d":"4.00E-162"},"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam08333","DUF1725","Protein of unknown function (DUF1725). This family include many eukaryotic and one bacterial sequence. Many of its members are annotated as being putative L1 retrotransposons or LINE-1 reverse transcriptase homologs. The region in question is found repeated in some family members.",".",".",".",".","."]
["ENSRNOG00000066676",1,0.083026661,8,0.514643505,0.161328492,-2.631926844,0.029383284,0.020488524,"down","yes","ENSRNOG00000066676","lncRNA","chr4:11773595-11783462:+","gi|149036607|gb|EDL91225.1|",133,{"v":4e-11,"d":"4.00E-11"},"rCG56442 [Rattus norvegicus]","gi|644988607|tpe|HG979546.1|",123,{"v":1e-55,"d":"1.00E-55"},"TPA: Mus musculus long non-coding RNA OTTMUST00000120169.1 (RP23-443N7.2 gene), lincRNA",".",".",".",".",".",".",".",".","pfam12449","DUF3684","Protein of unknown function (DUF3684). This domain family is found in eukaryotes, and is typically between 1072 and 1090 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000066826",1,0.083026661,8,0.514643505,0.161328492,-2.631926844,0.029383284,0.020488524,"down","yes","ENSRNOG00000066826","protein_coding","chr2:45405314-45405970:-","gi|114052555|ref|NP_001040560.1|",375,{"v":9e-43,"d":"9.00E-43"},"nucleolar protein 16 [Rattus norvegicus]","gi|675644374|ref|XM_002744520.3|",155,{"v":7e-74,"d":"7.00E-74"},"PREDICTED: Callithrix jacchus NOP16 nucleolar protein (NOP16), mRNA","Q1RP77",149,{"v":3e-44,"d":"3.00E-44"},"Nucleolar protein 16",".",".",".",".","pfam09420","Nop16","Ribosome biogenesis protein Nop16. Nop16 is a protein involved in ribosome biogenesis.",".",".",".",".","."]
["ENSRNOG00000068282",1,0.083026661,8,0.514643505,0.161328492,-2.631926844,0.029383284,0.020488524,"down","yes","U6","snRNA","chr4:146200474-146200580:+","gi|965792038|ref|XP_014963564.1|",128,2e-07,"PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC106992171 [Ovis aries musimon]","gi|937346585|ref|NG_044010.1|",59,{"v":4e-21,"d":"4.00E-21"},"Homo sapiens RNA, U6 small nuclear 73, pseudogene (RNU6-73P) on chromosome 13",".",".",".",".",".",".",".",".","pfam15110","TMEM141","TMEM141 protein family. The function of this family of transmembrane proteins, TMEM141, has not, as yet, been determined. Members of this family remain uncharacterized. TMEM141 protein family is found in eukaryotes. Proteins in this family are typically between 103 and 124 amino acids in length. There are two completely conserved residues (C and W) that may be functionally important.",".",".",".",".","."]
["ENSRNOG00000068846",1,0.083026661,8,0.514643505,0.161328492,-2.631926844,0.029383284,0.020488524,"down","yes","ENSRNOG00000068846","lncRNA","chr7:110968014-110981134:+",".",".",".",".","gi|354788923|gb|JN953424.1|",568,0,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Csnk1e:tm1a(KOMP)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam15374","CCDC71L","Coiled-coil domain-containing protein 71L. The protein family, Coiled-coil domain-containing protein 71L, is a domain of unknown function, which is found in eukaryotes.",".",".",".",".","."]
["ENSRNOG00000062781",12,0.996319926,31,1.994243584,0.49959791,-1.001160653,0.030481548,0.021182718,"down","yes","Ugt2b10","protein_coding","chr14:21108006-21127828:+","gi|300794198|ref|NP_001178605.1|",2688,0,"UDP-glucuronosyltransferase 2B10 precursor [Rattus norvegicus]","gi|300794197|ref|NM_001191676.1|",1599,0,"Rattus norvegicus UDP glucuronosyltransferase 2 family, polypeptide B10 (Ugt2b10), mRNA","Q6K1J1",766,0,"UDP-glucuronosyltransferase 2B31","slr1125",70.1,{"v":7e-12,"d":"7.00E-12"},"COG1819","pfam00201","UDPGT","UDP-glucoronosyl and UDP-glucosyl transferase.",".",".",".",".","."]
["ENSRNOG00000000507",3,0.249079982,13,0.836295696,0.297837216,-1.747404061,0.031636105,0.021880426,"down","yes","Tulp1","protein_coding","chr20:6412171-6424073:-","gi|564397273|ref|XP_006256279.1|",2046,0,"PREDICTED: tubby-related protein 1 isoform X1 [Rattus norvegicus]","gi|672085998|ref|XM_006256217.2|",2023,0,"PREDICTED: Rattus norvegicus tubby like protein 1 (Tulp1), transcript variant X1, mRNA","Q9Z273",726,0,"Tubby-related protein 1",".",".",".",".","pfam01167","Tub","Tub family.","GO:0001895|retina homeostasis;GO:0006910|phagocytosis, recognition;GO:0008150|biological_process;GO:0016192|vesicle-mediated transport;GO:0016358|dendrite development;GO:0042462|eye photoreceptor cell development;GO:0045494|photoreceptor cell maintenance;GO:0050766|positive regulation of phagocytosis;GO:0050908|detection of light stimulus involved in visual perception;GO:0060041|retina development in camera-type eye;GO:0061512|protein localization to cilium;GO:1903546|protein localization to photoreceptor outer segment;","GO:0001750|photoreceptor outer segment;GO:0001917|photoreceptor inner segment;GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005929|cilium;GO:0042995|cell projection;GO:0043679|axon terminus;GO:0045202|synapse;","GO:0003674|molecular_function;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0051015|actin filament binding;","K19600","TUB, TULP; tubby and related proteins"]
["ENSRNOG00000002800",3,0.249079982,13,0.836295696,0.297837216,-1.747404061,0.031636105,0.021880426,"down","yes","Gdpd2","protein_coding","chrX:65826574-65835361:+","gi|564399524|ref|XP_006257125.1|",2374,0,"PREDICTED: glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform X2 [Rattus norvegicus]","gi|157818782|ref|NM_001106944.1|",2500,0,"Rattus norvegicus glycerophosphodiester phosphodiesterase domain containing 2 (Gdpd2), mRNA","Q9ESM6",845,0,"Glycerophosphoinositol inositolphosphodiesterase GDPD2","PA2352",83.2,{"v":4e-16,"d":"4.00E-16"},"COG0584","pfam03009","GDPD","Glycerophosphoryl diester phosphodiesterase family. Escherichia coli has two sequence related isozymes of glycerophosphoryl diester phosphodiesterase (GDPD) - periplasmic and cytosolic. This family also includes agrocinopine synthase, the similarity to GDPD has been noted. This family appears to have weak but not significant matches to mammalian phospholipase C pfam00388, which suggests that this family may adopt a TIM barrel fold.","GO:0006629|lipid metabolic process;GO:0045669|positive regulation of osteoblast differentiation;GO:0090527|actin filament reorganization;","GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030027|lamellipodium;","GO:0008081|phosphoric diester hydrolase activity;","K01124","GDPD2; glycerophosphoinositol inositolphosphodiesterase [EC:3.1.4.43]"]
["ENSRNOG00000013372",3,0.249079982,13,0.836295696,0.297837216,-1.747404061,0.031636105,0.021880426,"down","yes","Shisal2b","protein_coding","chr2:36002651-36019123:-","gi|672015373|ref|XP_001072885.2|",720,{"v":7e-93,"d":"7.00E-93"},"PREDICTED: membrane protein FAM159B [Rattus norvegicus]","gi|672015372|ref|XM_001072885.5|",535,0,"PREDICTED: Rattus norvegicus family with sequence similarity 159, member B (Fam159b), mRNA","Q9D1Y9",253,{"v":1E-84,"d":"1.00E-84"},"Protein shisa-like-2B",".",".",".",".","pfam13908","Shisa","Wnt and FGF inhibitory regulator. Shisa is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000037688",3,0.249079982,13,0.836295696,0.297837216,-1.747404061,0.031636105,0.021880426,"down","yes","Ak9","protein_coding","chr20:44724496-44941136:+","gi|672031948|ref|XP_008773227.1|",6208,0,"PREDICTED: adenylate kinase 9 isoform X3, partial [Rattus norvegicus]","gi|672086760|ref|XM_008773020.1|",6196,0,"PREDICTED: Rattus norvegicus similar to novel protein (RGD1560386), transcript variant X5, mRNA","Q5TCS8",1544,0,"Adenylate kinase 9","CAC3112",71.2,{"v":3e-12,"d":"3.00E-12"},"COG0563","pfam00406","ADK","Adenylate kinase.","GO:0006174|dADP phosphorylation;GO:0006186|dGDP phosphorylation;GO:0006756|AMP phosphorylation;GO:0006757|ATP generation from ADP;GO:0061508|CDP phosphorylation;GO:0061565|dAMP phosphorylation;GO:0061566|CMP phosphorylation;GO:0061567|dCMP phosphorylation;GO:0061568|GDP phosphorylation;GO:0061569|UDP phosphorylation;GO:0061570|dCDP phosphorylation;GO:0061571|TDP phosphorylation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0031965|nuclear membrane;","GO:0004017|adenylate kinase activity;GO:0004550|nucleoside diphosphate kinase activity;GO:0005524|ATP binding;GO:0050145|nucleoside monophosphate kinase activity;","K18533","AK9; adenylate/nucleoside-diphosphate kinase [EC:2.7.4.3 2.7.4.6]"]
["ENSRNOG00000053406",3,0.249079982,13,0.836295696,0.297837216,-1.747404061,0.031636105,0.021880426,"down","yes","Gramd1c","protein_coding","chr11:56633227-56718570:+","gi|300797224|ref|NP_001178755.1|",3263,0,"GRAM domain-containing protein 1C [Rattus norvegicus]","gi|755553289|ref|XM_011245853.1|",2087,0,"PREDICTED: Mus musculus GRAM domain containing 1C (Gramd1c), transcript variant X1, mRNA","Q8IYS0",1052,0,"GRAM domain-containing protein 1C",".",".",".",".","pfam02893","GRAM","GRAM domain. The GRAM domain is found in in glucosyltransferases, myotubularins and other putative membrane-associated proteins.","GO:0015918|sterol transport;GO:0071397|cellular response to cholesterol;GO:0120009|intermembrane lipid transfer;","GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0015485|cholesterol binding;GO:0120020|intermembrane cholesterol transfer activity;",".","."]
["ENSRNOG00000058615",3,0.249079982,13,0.836295696,0.297837216,-1.747404061,0.031636105,0.021880426,"down","yes","U6","snRNA","chr1:181153246-181153352:-","gi|686705190|ref|XP_009231420.1|",124,9e-08,"PREDICTED: actin, alpha skeletal muscle-like [Pongo abelii]",".",".",".",".",".",".",".",".",".",".",".",".","pfam06750","DiS_P_DiS","Bacterial Peptidase A24 N-terminal domain. This family is found at the N-terminus of the pre-pilin peptidases (pfam01478). It's function has not been specifically determined; however some of the family have been characterized as bifunctional, and this domain may contain the N-methylation activity (EC:2.1.1.-). It consists of an intracellular region between a pair of transmembrane. This region contains an invariant proline and two almost fully conserved disulphide bridges - hence the name DiS-P-DiS. The cysteines have been shown to be essential to the overall function of the enzyme in, but their role was incorrectly ascribed.",".",".",".",".","."]
["ENSRNOG00000066622",3,0.249079982,13,0.836295696,0.297837216,-1.747404061,0.031636105,0.021880426,"down","yes","ENSRNOG00000066622","lncRNA","chr7:62784299-62787126:-",".",".",".",".","gi|672021747|ref|XR_601776.1|",302,{"v":2E-155,"d":"2.00E-155"},"PREDICTED: Rattus norvegicus uncharacterized LOC103690358 (LOC103690358), ncRNA",".",".",".",".",".",".",".",".","pfam03188","Cytochrom_B561","Eukaryotic cytochrome b561. Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.",".",".",".",".","."]
["ENSRNOG00000067538",3,0.249079982,13,0.836295696,0.297837216,-1.747404061,0.031636105,0.021880426,"down","yes","ENSRNOG00000067538","lncRNA","chr6:14081555-14149061:-","gi|149057382|gb|EDM08705.1|",216,{"v":8e-18,"d":"8.00E-18"},"similar to RIKEN cDNA 3110040N11, isoform CRA_b [Rattus norvegicus]","gi|755489069|ref|XR_883762.1|",82,{"v":1e-32,"d":"1.00E-32"},"PREDICTED: Mus musculus RIKEN cDNA C230072F16 gene (C230072F16Rik), transcript variant X11, ncRNA",".",".",".",".",".",".",".",".","pfam11122","Spore-coat_CotD","Inner spore coat protein D. This family is conserved in the Enterobacteriaceae family. CotD is an inner spore coat protein that is expressed in the middle phase of mother cell gene expression. Along with CotD, CotH, CotS and CotT it is assumed to assemble into the loose skeleton of the matrix, between the shells of SpoIVA and CotE. Coat proteins do not share much sequence similarity between species, but this does not imply they do not share secondary, tertiary, or quaternary features.",".",".",".",".","."]
["ENSRNOG00000067969",3,0.249079982,13,0.836295696,0.297837216,-1.747404061,0.031636105,0.021880426,"down","yes","ENSRNOG00000067969","lncRNA","chr8:109263313-109264986:+",".",".",".",".","gi|568963087|ref|XM_006511792.1|",1032,0,"PREDICTED: Mus musculus DALR anticodon binding domain containing 3 (Dalrd3), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam13340","DUF4096","Putative transposase of IS4/5 family (DUF4096).",".",".",".",".","."]
["ENSRNOG00000021916",11,0.913293266,29,1.865582707,0.489548527,-1.03047622,0.032098744,0.022174017,"down","yes","Slc16a12","protein_coding","chr1:232185907-232262141:-","gi|347300453|ref|NP_001178566.1|",2530,0,"monocarboxylate transporter 12 [Rattus norvegicus]","gi|347300452|ref|NM_001191637.1|",1876,0,"Rattus norvegicus solute carrier family 16, member 12 (Slc16a12), mRNA","Q8BGC3",932,0,"Monocarboxylate transporter 12","AF0367",107,{"v":7e-24,"d":"7.00E-24"},"COG0477","pfam07690","MFS_1","Major Facilitator Superfamily.","GO:0008150|biological_process;GO:0015718|monocarboxylic acid transport;GO:0015881|creatine transmembrane transport;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;","GO:0003674|molecular_function;GO:0005308|creatine transmembrane transporter activity;GO:0008028|monocarboxylic acid transmembrane transporter activity;GO:0015293|symporter activity;","K11810","SLC16A12; MFS transporter, MCT family, solute carrier family 16 (monocarboxylic acid transporters), member 12"]
["ENSRNOG00000010320",10,0.830266605,27,1.736921831,0.478010346,-1.064886251,0.033644637,0.023151884,"down","yes","Efnb3","protein_coding","chr10:54274506-54280471:-","gi|158303312|ref|NP_001094450.2|",1322,{"v":2E-170,"d":"2.00E-170"},"ephrin-B3 precursor [Rattus norvegicus]","gi|695130839|ref|NM_001100980.4|",3114,0,"Rattus norvegicus ephrin B3 (Efnb3), mRNA","O35393",503,{"v":8e-168,"d":"8.00E-168"},"Ephrin-B3",".",".",".",".","pfam00812","Ephrin","Ephrin.","GO:0007411|axon guidance;GO:0007628|adult walking behavior;GO:0016198|axon choice point recognition;GO:0031295|T cell costimulation;GO:0048013|ephrin receptor signaling pathway;GO:0050771|negative regulation of axonogenesis;GO:0099557|trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission;","GO:0005886|plasma membrane;GO:0098686|hippocampal mossy fiber to CA3 synapse;GO:0098978|glutamatergic synapse;GO:0099056|integral component of presynaptic membrane;GO:0099061|integral component of postsynaptic density membrane;","GO:0046875|ephrin receptor binding;","K05463","EFNB; ephrin-B"]
["ENSRNOG00000055020",9,0.747239945,25,1.608260955,0.464626056,-1.105858032,0.035053198,0.024018435,"down","yes","ENSRNOG00000055020","pseudogene","chr1:39601959-39603122:-","gi|507640871|ref|XP_004701506.1|",986,{"v":8e-129,"d":"8.00E-129"},"PREDICTED: heterogeneous nuclear ribonucleoprotein A3 isoform X3 [Echinops telfairi]","gi|34333453|gb|AY363226.1|",1125,0,"Rattus norvegicus heterogeneous nuclear ribonucleoprotein A3 variant a mRNA, complete cds; alternatively spliced","P51991",371,{"v":2e-124,"d":"2.00E-124"},"Heterogeneous nuclear ribonucleoprotein A3",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.",".",".",".",".","."]
["ENSRNOG00000010459",4,0.332106642,15,0.964956573,0.344167449,-1.538817439,0.035061687,0.024018435,"down","yes","Fbxo43","protein_coding","chr7:67333162-67346751:-","gi|209915571|ref|NP_001012117.2|",3170,0,"F-box only protein 43 [Rattus norvegicus]","gi|58865803|ref|NM_001012117.1|",2525,0,"Rattus norvegicus F-box protein 43 (Fbxo43), mRNA","Q66H04",1223,0,"F-box only protein 43",".",".",".",".","pfam01485","IBR","IBR domain. The IBR (In Between Ring fingers) domain is often found to occur between pairs of ring fingers (pfam00097). This domain has also been called the C6HC domain and DRIL (for double RING finger linked) domain. Proteins that contain two Ring fingers and an IBR domain (these proteins are also termed RBR family proteins) are thought to exist in all eukaryotic organisms. RBR family members play roles in protein quality control and can indirectly regulate transcription. Evidence suggests that RBR proteins are often parts of cullin-containing ubiquitin ligase complexes. The ubiquitin ligase Parkin is an RBR family protein whose mutations are involved in forms of familial Parkinson's disease.","GO:0007088|regulation of mitotic nuclear division;GO:0016567|protein ubiquitination;GO:0040020|regulation of meiotic nuclear division;GO:0042177|negative regulation of protein catabolic process;GO:0045835|negative regulation of meiotic nuclear division;GO:0051321|meiotic cell cycle;","GO:0005634|nucleus;","GO:0046872|metal ion binding;","K10318","FBXO43, EMI2; F-box protein 43"]
["ENSRNOG00000024717",4,0.332106642,15,0.964956573,0.344167449,-1.538817439,0.035061687,0.024018435,"down","yes","Espnl","protein_coding","chr9:91912049-91935292:+","gi|300796937|ref|NP_001178741.1|",4644,0,"espin-like protein [Rattus norvegicus]","gi|300796936|ref|NM_001191812.1|",3000,0,"Rattus norvegicus espin-like (Espnl), mRNA","Q3UYR4",1693,0,"Espin-like protein","all2748",93.6,{"v":3e-19,"d":"3.00E-19"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0007605|sensory perception of sound;GO:0051017|actin filament bundle assembly;","GO:0005737|cytoplasm;GO:0032426|stereocilium tip;","GO:0051015|actin filament binding;","K24047","ESPN; espin"]
["ENSRNOG00000031951",4,0.332106642,15,0.964956573,0.344167449,-1.538817439,0.035061687,0.024018435,"down","yes","ENSRNOG00000031951","protein_coding","chr3:44581068-44630051:+","gi|295391840|ref|NP_001171287.1|",3053,0,"uncharacterized protein LOC100361645 [Rattus norvegicus]","gi|295391839|ref|NM_001177816.1|",1755,0,"Rattus norvegicus LRRGT00075-like (LOC100361645), mRNA","P11369",185,{"v":6e-48,"d":"6.00E-48"},"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam12488","DUF3704","Protein of unknown function (DUF3704). This domain family is found in eukaryotes, and is approximately 30 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000047143",4,0.332106642,15,0.964956573,0.344167449,-1.538817439,0.035061687,0.024018435,"down","yes","Fkbp1b","protein_coding","chr6:27838802-27848653:-","gi|12083613|ref|NP_073166.1|",574,{"v":8E-70,"d":"8.00E-70"},"peptidyl-prolyl cis-trans isomerase FKBP1B [Rattus norvegicus]","gi|123173727|ref|NM_016863.3|",752,0,"Mus musculus FK506 binding protein 1b (Fkbp1b), mRNA","P97534",225,{"v":3e-71,"d":"3.00E-71"},"Peptidyl-prolyl cis-trans isomerase FKBP1B","SPBC839.17c",132,{"v":4e-36,"d":"4.00E-36"},"COG0545","pfam00254","FKBP_C","FKBP-type peptidyl-prolyl cis-trans isomerase.","GO:0000413|protein peptidyl-prolyl isomerization;GO:0002027|regulation of heart rate;GO:0006939|smooth muscle contraction;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0009749|response to glucose;GO:0010033|response to organic substance;GO:0010459|negative regulation of heart rate;GO:0010880|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0010881|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;GO:0019227|neuronal action potential propagation;GO:0030073|insulin secretion;GO:0032515|negative regulation of phosphoprotein phosphatase activity;GO:0033197|response to vitamin E;GO:0042098|T cell proliferation;GO:0042542|response to hydrogen peroxide;GO:0048680|positive regulation of axon regeneration;GO:0051209|release of sequestered calcium ion into cytosol;GO:0051280|negative regulation of release of sequestered calcium ion into cytosol;GO:0051284|positive regulation of sequestering of calcium ion;GO:0051480|regulation of cytosolic calcium ion concentration;GO:0051775|response to redox state;GO:0060314|regulation of ryanodine-sensitive calcium-release channel activity;GO:0060315|negative regulation of ryanodine-sensitive calcium-release channel activity;GO:0061077|chaperone-mediated protein folding;GO:0061179|negative regulation of insulin secretion involved in cellular response to glucose stimulus;","GO:0005737|cytoplasm;GO:0016020|membrane;GO:0016529|sarcoplasmic reticulum;GO:0030018|Z disc;GO:0033017|sarcoplasmic reticulum membrane;GO:0034704|calcium channel complex;GO:0043231|intracellular membrane-bounded organelle;","GO:0003755|peptidyl-prolyl cis-trans isomerase activity;GO:0005102|signaling receptor binding;GO:0005528|FK506 binding;GO:0019855|calcium channel inhibitor activity;GO:0030551|cyclic nucleotide binding;GO:0044325|ion channel binding;","K09568","FKBP1; FK506-binding protein 1 [EC:5.2.1.8]"]
["ENSRNOG00000057108",4,0.332106642,15,0.964956573,0.344167449,-1.538817439,0.035061687,0.024018435,"down","yes","AABR07066109.1","snoRNA","chr9:4281481-4281609:-",".",".",".",".","gi|672060403|ref|XR_593658.1|",129,{"v":6e-60,"d":"6.00E-60"},"PREDICTED: Rattus norvegicus uncharacterized LOC102549144 (LOC102549144), transcript variant X4, ncRNA",".",".",".",".",".",".",".",".","pfam05940","NnrS","NnrS protein. This family consists of several bacterial NnrS like proteins. NnrS is a putative heme-Cu protein (NnrS) and a member of the short-chain dehydrogenase family. Expression of nnrS is dependent on the transcriptional regulator NnrR, which also regulates expression of genes required for the reduction of nitrite to nitrous oxide, including nirK and nor. NnrS is a haem- and copper-containing membrane protein. Genes encoding putative orthologues of NnrS are sometimes but not always found in bacteria encoding nitrite and/or nitric oxide reductase.",".",".",".",".","."]
["ENSRNOG00000019771",8,0.664213284,23,1.479600078,0.448914064,-1.1554888,0.036231549,0.024729749,"down","yes","Tbx6","protein_coding","chr1:181388684-181392593:+","gi|157821423|ref|NP_001102390.1|",1998,0,"T-box transcription factor TBX6 [Rattus norvegicus]","gi|157821422|ref|NM_001108920.1|",1726,0,"Rattus norvegicus T-box 6 (Tbx6), mRNA","D3ZJK7",753,0,"T-box transcription factor TBX6",".",".",".",".","pfam00907","T-box","T-box. The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001707|mesoderm formation;GO:0001708|cell fate specification;GO:0001947|heart looping;GO:0003205|cardiac chamber development;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007417|central nervous system development;GO:0008150|biological_process;GO:0008284|positive regulation of cell proliferation;GO:0010977|negative regulation of neuron projection development;GO:0014043|negative regulation of neuron maturation;GO:0023019|signal transduction involved in regulation of gene expression;GO:0032525|somite rostral/caudal axis specification;GO:0043433|negative regulation of DNA-binding transcription factor activity;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0000785|chromatin;GO:0005575|cellular_component;GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;GO:1990837|sequence-specific double-stranded DNA binding;","K10180","TBX6; T-box protein 6"]
["ENSRNOG00000056599",5,0.415133303,17,1.093617449,0.379596451,-1.39746159,0.036781903,0.025025251,"down","yes","Gm24119","snoRNA","chr7:25613357-25613602:-",".",".",".",".","gi|908663278|tpe|LN872483.1|",200,{"v":4e-99,"d":"4.00E-99"},"TPA: Mus musculus SNORA53 (ACA53) gene for small nucleolar RNA SNORA53 (ACA53)",".",".",".",".",".",".",".",".","pfam09603","Fib_succ_major","Fibrobacter succinogenes major domain (Fib_succ_major). This domain of about 175 to 200 amino acids is found, in from one to five copies, in over 50 proteins in Fibrobacter succinogenes S85, an obligate anaerobe of the rumen. Many members of this family have an apparent lipoprotein signal sequence. Conserved cysteine residues, suggestive of disulfide bond formation, are also consistent with an extracytoplasmic location for this domain. This domain can also be found in small numbers of proteins in Chlorobium tepidum and Bacteroides thetaiotaomicron.",".",".",".",".","."]
["ENSRNOG00000012566",7,0.581186624,21,1.350939202,0.430209311,-1.216889345,0.037048808,0.025180052,"down","yes","Kcnv2","protein_coding","chr1:224999552-225014062:+","gi|157822321|ref|NP_001099840.1|",2749,0,"potassium voltage-gated channel subfamily V member 2 [Rattus norvegicus]","gi|157822320|ref|NM_001106370.1|",5195,0,"Rattus norvegicus potassium voltage-gated channel modifier subfamily V member 2 (Kcnv2), mRNA","Q8CFS6",996,0,"Potassium voltage-gated channel subfamily V member 2","DR0830",80.1,{"v":5E-15,"d":"5.00E-15"},"COG1226","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0034765|regulation of ion transmembrane transport;GO:0051260|protein homooligomerization;GO:0071805|potassium ion transmembrane transport;","GO:0008076|voltage-gated potassium channel complex;GO:0016021|integral component of membrane;","GO:0005249|voltage-gated potassium channel activity;","K04935","KCNV2, KV8.2; potassium channel subfamily V member 2"]
["ENSRNOG00000014702",7,0.581186624,21,1.350939202,0.430209311,-1.216889345,0.037048808,0.025180052,"down","yes","Elovl2","protein_coding","chr17:23544568-23584848:+","gi|532023594|ref|XP_005355137.1|",1506,0,"PREDICTED: elongation of very long chain fatty acids protein 2 [Microtus ochrogaster]","gi|672081513|ref|XM_006253779.2|",3607,0,"PREDICTED: Rattus norvegicus ELOVL fatty acid elongase 2 (Elovl2), transcript variant X1, mRNA","D4A612",580,0,"Elongation of very long chain fatty acids protein 2",".",".",".",".","pfam01151","ELO","GNS1/SUR4 family. Members of this family are involved in long chain fatty acid elongation systems that produce the 26-carbon precursors for ceramide and sphingolipid synthesis. Predicted to be integral membrane proteins, in eukaryotes they are probably located on the endoplasmic reticulum. Yeast ELO3 affects plasma membrane H+-ATPase activity, and may act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1.","GO:0000038|very long-chain fatty acid metabolic process;GO:0006636|unsaturated fatty acid biosynthetic process;GO:0019367|fatty acid elongation, saturated fatty acid;GO:0030148|sphingolipid biosynthetic process;GO:0034625|fatty acid elongation, monounsaturated fatty acid;GO:0034626|fatty acid elongation, polyunsaturated fatty acid;GO:0042761|very long-chain fatty acid biosynthetic process;","GO:0005783|endoplasmic reticulum;GO:0030176|integral component of endoplasmic reticulum membrane;","GO:0009922|fatty acid elongase activity;GO:0016747|transferase activity, transferring acyl groups other than amino-acyl groups;GO:0102336|3-oxo-arachidoyl-CoA synthase activity;GO:0102337|3-oxo-cerotoyl-CoA synthase activity;GO:0102338|3-oxo-lignoceronyl-CoA synthase activity;GO:0102756|very-long-chain 3-ketoacyl-CoA synthase activity;","K10205","ELOVL2; elongation of very long chain fatty acids protein 2 [EC:2.3.1.199]"]
["ENSRNOG00000017805",7,0.581186624,21,1.350939202,0.430209311,-1.216889345,0.037048808,0.025180052,"down","yes","Duoxa2","protein_coding","chr3:109245476-109248968:+","gi|300794845|ref|NP_001178894.1|",1250,{"v":3e-169,"d":"3.00E-169"},"dual oxidase maturation factor 2 [Rattus norvegicus]","gi|300794844|ref|NM_001191965.1|",963,0,"Rattus norvegicus dual oxidase maturation factor 2 (Duoxa2), mRNA","Q9D311",441,{"v":5e-153,"d":"5.00E-153"},"Dual oxidase maturation factor 2",".",".",".",".","pfam10204","DuoxA","Dual oxidase maturation factor. DuoxA (Dual oxidase maturation factor) is the essential protein necessary for the final release of DUOX2 (an NADPH:O2 oxidoreductase flavoprotein) from the endoplasmic reticulum. Dual oxidases (DUOX1 and DUOX2) constitute the catalytic core of the hydrogen peroxide generator, which generates H2O2 at the apical membrane of thyroid follicular cells, essential for iodination of thyroglobulin by thyroid peroxidases. DuoxA carries five membrane-integral regions including a reverse signal-anchor with external N-terminus (type III) and two N-glycosylation sites. It is conserved from nematodes to humans.","GO:0008104|protein localization;GO:0010729|positive regulation of hydrogen peroxide biosynthetic process;GO:0015031|protein transport;GO:0034613|cellular protein localization;GO:0042743|hydrogen peroxide metabolic process;GO:0050727|regulation of inflammatory response;GO:0051604|protein maturation;GO:2000147|positive regulation of cell motility;GO:2000609|regulation of thyroid hormone generation;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0031252|cell leading edge;GO:0045177|apical part of cell;","GO:0019899|enzyme binding;","K17232","DUOXA2; dual oxidase maturation factor 2"]
["ENSRNOG00000021892",7,0.581186624,21,1.350939202,0.430209311,-1.216889345,0.037048808,0.025180052,"down","yes","Ccdc38","protein_coding","chr7:28059798-28130441:+","gi|109481859|ref|XP_001080322.1|",2946,0,"PREDICTED: coiled-coil domain-containing protein 38 isoform X1 [Rattus norvegicus]","gi|672021556|ref|XM_001080322.3|",2296,0,"PREDICTED: Rattus norvegicus coiled-coil domain containing 38 (Ccdc38), transcript variant X1, mRNA","Q8CDN8",855,0,"Coiled-coil domain-containing protein 38",".",".",".",".","pfam13863","DUF4200","Domain of unknown function (DUF4200). This family is found in eukaryotes. It is a coiled-coil domain of unknwon function.",".","GO:0005813|centrosome;",".",".","."]
["ENSRNOG00000039086",7,0.581186624,21,1.350939202,0.430209311,-1.216889345,0.037048808,0.025180052,"down","yes","Ccdc153","protein_coding","chr8:44577836-44584338:+","gi|62078635|ref|NP_001013975.1|",759,{"v":2E-95,"d":"2.00E-95"},"coiled-coil domain-containing protein 153 [Rattus norvegicus]","gi|62078634|ref|NM_001013953.1|",1362,0,"Rattus norvegicus coiled-coil domain containing 153 (Ccdc153), mRNA",".",".",".",".",".",".",".",".","pfam04012","PspA_IM30","PspA/IM30 family. This family includes PspA a protein that suppresses sigma54-dependent transcription. The PspA protein, a negative regulator of the Escherichia coli phage shock psp operon, is produced when virulence factors are exported through secretins in many Gram-negative pathogenic bacteria and its homologue in plants, VIPP1, plays a critical role in thylakoid biogenesis, essential for photosynthesis. Activation of transcription by the enhancer-dependent bacterial sigma(54) containing RNA polymerase occurs through ATP hydrolysis-driven protein conformational changes enabled by activator proteins that belong to the large AAA(+) mechanochemical protein family. It has been shown that PspA directly and specifically acts upon and binds to the AAA(+) domain of the PspF transcription activator.",".",".","GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000001581",0,0.04151333,6,0.385982629,0.107552328,-3.216889345,0.037207666,0.025195532,"down","yes","Hoxd10","protein_coding","chr3:59594516-59597725:+","gi|880859841|ref|XP_005065198.2|",1863,0,"PREDICTED: homeobox protein Hox-D10 [Mesocricetus auratus]","gi|157819366|ref|NM_001107094.1|",1848,0,"Rattus norvegicus homeo box D10 (Hoxd10), mRNA","P28359",648,0,"Homeobox protein Hox-D10",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0001501|skeletal system development;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007338|single fertilization;GO:0007519|skeletal muscle tissue development;GO:0008344|adult locomotory behavior;GO:0009952|anterior/posterior pattern specification;GO:0009954|proximal/distal pattern formation;GO:0010468|regulation of gene expression;GO:0021520|spinal cord motor neuron cell fate specification;GO:0030326|embryonic limb morphogenesis;GO:0035136|forelimb morphogenesis;GO:0035137|hindlimb morphogenesis;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048704|embryonic skeletal system morphogenesis;GO:0048935|peripheral nervous system neuron development;GO:0050905|neuromuscular process;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0036464|cytoplasmic ribonucleoprotein granule;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003700|DNA-binding transcription factor activity;GO:1990837|sequence-specific double-stranded DNA binding;","K09295","HOXD10; homrobox protein Hox-D10"]
["ENSRNOG00000002346",0,0.04151333,6,0.385982629,0.107552328,-3.216889345,0.037207666,0.025195532,"down","yes","Tbx22","protein_coding","chrX:72723617-72774647:+","gi|564399798|ref|XP_006257223.1|",2433,0,"PREDICTED: T-box transcription factor TBX22 isoform X3 [Rattus norvegicus]","gi|157818350|ref|NM_001106937.1|",4834,0,"Rattus norvegicus T-box 22 (Tbx22), mRNA","Q8K402",823,0,"T-box transcription factor TBX22",".",".",".",".","pfam00907","T-box","T-box. The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001708|cell fate specification;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008150|biological_process;GO:0045892|negative regulation of transcription, DNA-templated;","GO:0005575|cellular_component;GO:0005634|nucleus;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003677|DNA binding;","K10186","TBX22; T-box protein 22"]
["ENSRNOG00000002593",0,0.04151333,6,0.385982629,0.107552328,-3.216889345,0.037207666,0.025195532,"down","yes","Esrrg","protein_coding","chr13:99564669-99783397:+","gi|6753774|ref|NP_036065.1|",2372,0,"estrogen-related receptor gamma isoform1 [Mus musculus]","gi|672075170|ref|XM_006250443.2|",3074,0,"PREDICTED: Rattus norvegicus estrogen-related receptor gamma (Esrrg), transcript variant X1, mRNA","P62510",917,0,"Estrogen-related receptor gamma",".",".",".",".","pfam00105","zf-C4","Zinc finger, C4 type (two domains). In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.","GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0043401|steroid hormone mediated signaling pathway;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048384|retinoic acid receptor signaling pathway;GO:0120162|positive regulation of cold-induced thermogenesis;","GO:0005634|nucleus;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003707|steroid hormone receptor activity;GO:0004879|nuclear receptor activity;GO:0005496|steroid binding;GO:0008270|zinc ion binding;GO:0042802|identical protein binding;GO:0050682|AF-2 domain binding;GO:1990837|sequence-specific double-stranded DNA binding;","K08554","NR3B3, ESRRG; estrogen-related receptor gamma"]
["ENSRNOG00000003469",0,0.04151333,6,0.385982629,0.107552328,-3.216889345,0.037207666,0.025195532,"down","yes","MAST1","protein_coding","chr19:23207991-23244235:+","gi|30842796|ref|NP_851603.1|",7191,0,"microtubule-associated serine/threonine-protein kinase 1 [Rattus norvegicus]","gi|30842795|ref|NM_181089.1|",4654,0,"Rattus norvegicus microtubule associated serine/threonine kinase 1 (MAST1), mRNA","Q810W7",2774,0,"Microtubule-associated serine/threonine-protein kinase 1",".",".",".",".","pfam08926","DUF1908","Domain of unknown function (DUF1908). This domain is found in a set of hypothetical/structural eukaryotic proteins.","GO:0006468|protein phosphorylation;GO:0007010|cytoskeleton organization;GO:0007420|brain development;GO:0018105|peptidyl-serine phosphorylation;GO:0035556|intracellular signal transduction;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0043005|neuron projection;GO:0043025|neuronal cell body;","GO:0000287|magnesium ion binding;GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;GO:0008017|microtubule binding;","K08789","MAST; microtubule-associated serine/threonine kinase [EC:2.7.11.1]"]
["ENSRNOG00000004706",0,0.04151333,6,0.385982629,0.107552328,-3.216889345,0.037207666,0.025195532,"down","yes","Vit","protein_coding","chr6:16445955-16565665:-","gi|672055181|ref|XP_008762649.1|",3485,0,"PREDICTED: vitrin [Rattus norvegicus]","gi|672055180|ref|XM_008764427.1|",2466,0,"PREDICTED: Rattus norvegicus vitrin (Vit), mRNA","Q8VHI5",1234,0,"Vitrin",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0010811|positive regulation of cell-substrate adhesion;GO:0021510|spinal cord development;GO:0030198|extracellular matrix organization;","GO:0005576|extracellular region;GO:0005614|interstitial matrix;GO:0031012|extracellular matrix;GO:0062023|collagen-containing extracellular matrix;","GO:0005539|glycosaminoglycan binding;","K24506","VIT; vitrin"]
["ENSRNOG00000012195",0,0.04151333,6,0.385982629,0.107552328,-3.216889345,0.037207666,0.025195532,"down","yes","Tas2r108","protein_coding","chr4:69287667-69288581:+","gi|67010021|ref|NP_001019857.1|",1347,0,"taste receptor type 2 member 4 [Rattus norvegicus]","gi|67010020|ref|NM_001024686.1|",915,0,"Rattus norvegicus taste receptor, type 2, member 108 (Tas2r108), mRNA","Q67ET0",523,0,"Taste receptor type 2 member 4",".",".",".",".","pfam05296","TAS2R","Mammalian taste receptor protein (TAS2R). This family consists of several forms of mammalian taste receptor proteins (TAS2Rs). TAS2Rs are G protein-coupled receptors expressed in subsets of taste receptor cells of the tongue and palate epithelia and are organized in the genome in clusters. The proteins are genetically linked to loci that influence bitter perception in mice and humans.","GO:0001580|detection of chemical stimulus involved in sensory perception of bitter taste;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007585|respiratory gaseous exchange;","GO:0016021|integral component of membrane;GO:0060170|ciliary membrane;","GO:0004930|G protein-coupled receptor activity;GO:0033038|bitter taste receptor activity;","K08474","TAS2R; taste receptor type 2"]
["ENSRNOG00000013407",0,0.04151333,6,0.385982629,0.107552328,-3.216889345,0.037207666,0.025195532,"down","yes","Slc5a11","protein_coding","chr1:177756561-177795193:+","gi|686661095|ref|NP_001093952.2|",3150,0,"sodium/myo-inositol cotransporter 2 [Rattus norvegicus]","gi|672037710|ref|XM_006230186.2|",2091,0,"PREDICTED: Rattus norvegicus solute carrier family 5 (sodium/inositol cotransporter), member 11 (Slc5a11), transcript variant X1, mRNA","Q9Z1F2",1192,0,"Sodium/myo-inositol cotransporter 2","BH2222",148,{"v":4e-37,"d":"4.00E-37"},"COG4146","pfam00474","SSF","Sodium:solute symporter family. Membership of this family is supported by a significant blast score.","GO:0006814|sodium ion transport;GO:0006915|apoptotic process;GO:0032409|regulation of transporter activity;GO:0055085|transmembrane transport;GO:1904659|glucose transmembrane transport;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;","GO:0005412|glucose:sodium symporter activity;GO:0022857|transmembrane transporter activity;","K14391","SLC5A11, SMIT2, SGLT6; solute carrier family 5 (sodium/myo-inositol cotransporter), member 11"]
["ENSRNOG00000015383",0,0.04151333,6,0.385982629,0.107552328,-3.216889345,0.037207666,0.025195532,"down","yes","Asxl3","protein_coding","chr18:13593985-13762427:+","gi|569003462|ref|XP_006525803.1|",9784,0,"PREDICTED: putative Polycomb group protein ASXL3 isoform X3 [Mus musculus]","gi|672082867|ref|XR_596915.1|",7534,0,"PREDICTED: Rattus norvegicus additional sex combs like transcriptional regulator 3 (Asxl3), transcript variant X3, misc_RNA","Q8C4A5",3773,0,"Putative Polycomb group protein ASXL3",".",".",".",".","pfam13919","ASXH","Asx homology domain. A conserved alpha helical domain with a characteristic LXXLL motif. The LXXLL motif is detected in diverse transcription factors, coactivators and corepressors and is implicated in mediating interactions between them. The ASXH domain is found in animals, fungi and plants and is predicted to play a role in mediating contact between transcription factors and chromatin-associated complexes. In Drosophila Asx and Human ASXL1, the ASXH domain is predicted to mediate interactions with the Calypso and BAP1 deubiquitinases (DUBs) which further belong to the UCHL5/UCH37 clade of DUBs.","GO:0051055|negative regulation of lipid biosynthetic process;",".","GO:0003677|DNA binding;GO:0046872|metal ion binding;",".","."]
["ENSRNOG00000017180",0,0.04151333,6,0.385982629,0.107552328,-3.216889345,0.037207666,0.025195532,"down","yes","Slc17a2","protein_coding","chr17:41319701-41336325:-","gi|157824099|ref|NP_001100823.1|",2082,0,"sodium-dependent phosphate transport protein 3 [Rattus norvegicus]","gi|157824098|ref|NM_001107353.1|",2822,0,"Rattus norvegicus solute carrier family 17, member 2 (Slc17a2), mRNA","Q5SZA1",766,0,"Sodium-dependent phosphate transport protein 3",".",".",".",".","pfam07690","MFS_1","Major Facilitator Superfamily.","GO:0006820|anion transport;GO:0015739|sialic acid transport;GO:0055085|transmembrane transport;","GO:0005764|lysosome;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;","GO:0015136|sialic acid transmembrane transporter activity;GO:0022857|transmembrane transporter activity;","K12300","SLC17A1S; MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 1/2/3/4"]
["ENSRNOG00000023457",0,0.04151333,6,0.385982629,0.107552328,-3.216889345,0.037207666,0.025195532,"down","yes","Stpg2","protein_coding","chr2:227764353-228285663:+","gi|155369668|ref|NP_001094463.1|",3009,0,"sperm-tail PG-rich repeat-containing protein 2 [Rattus norvegicus]","gi|155369667|ref|NM_001100993.1|",1900,0,"Rattus norvegicus sperm-tail PG-rich repeat containing 2 (Stpg2), mRNA",".",".",".",".",".",".",".",".","pfam00274","Glycolytic","Fructose-bisphosphate aldolase class-I.",".",".",".",".","."]
["ENSRNOG00000023828",0,0.04151333,6,0.385982629,0.107552328,-3.216889345,0.037207666,0.025195532,"down","yes","ENSRNOG00000023828","protein_coding","chr7:107838080-107845981:-","gi|392341530|ref|XP_003754360.1|",3590,0,"PREDICTED: uncharacterized protein LOC680875 [Rattus norvegicus]","gi|672022041|ref|XM_008776501.1|",2532,0,"PREDICTED: Rattus norvegicus similar to dystonin isoform 1 (LOC680875), transcript variant X2, mRNA","Q9UPN3",68.2,{"v":4e-10,"d":"4.00E-10"},"Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5",".",".",".",".","pfam02187","GAS2","Growth-Arrest-Specific Protein 2 Domain.","GO:0032886|regulation of microtubule-based process;GO:0042060|wound healing;GO:0045104|intermediate filament cytoskeleton organization;GO:0051893|regulation of focal adhesion assembly;","GO:0005737|cytoplasm;GO:0005874|microtubule;GO:0005882|intermediate filament;GO:0015629|actin cytoskeleton;GO:0016020|membrane;","GO:0005198|structural molecule activity;GO:0008017|microtubule binding;",".","."]
["ENSRNOG00000024093",0,0.04151333,6,0.385982629,0.107552328,-3.216889345,0.037207666,0.025195532,"down","yes","Dmrta1","protein_coding","chr5:104415893-104422433:+","gi|157822065|ref|NP_001101415.1|",2163,0,"doublesex- and mab-3-related transcription factor A1 [Rattus norvegicus]","gi|157822064|ref|NM_001107945.1|",4030,0,"Rattus norvegicus DMRT-like family A1 (Dmrta1), mRNA","Q8CFG4",775,0,"Doublesex- and mab-3-related transcription factor A1",".",".",".",".","pfam00751","DM","DM DNA binding domain. The DM domain is named after dsx and mab-3. dsx contains a single amino-terminal DM domain, whereas mab-3 contains two amino-terminal domains. The DM domain has a pattern of conserved zinc chelating residues C2H2C4. The dsx DM domain has been shown to dimerise and bind palindromic DNA.","GO:0001541|ovarian follicle development;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007281|germ cell development;GO:0007548|sex differentiation;GO:0060179|male mating behavior;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0042802|identical protein binding;GO:0043565|sequence-specific DNA binding;GO:0046872|metal ion binding;GO:1990837|sequence-specific double-stranded DNA binding;","K19491","DMRT4_5, DMRTA; doublesex- and mab-3-related transcription factor 4/5"]
["ENSRNOG00000026883",0,0.04151333,6,0.385982629,0.107552328,-3.216889345,0.037207666,0.025195532,"down","yes","Smco2","protein_coding","chr4:179765442-179791066:+","gi|392340192|ref|XP_003754008.1|",1766,0,"PREDICTED: single-pass membrane and coiled-coil domain-containing protein 2 isoform X1 [Rattus norvegicus]","gi|672018928|ref|XM_008775870.1|",1251,0,"PREDICTED: Rattus norvegicus single-pass membrane protein with coiled-coil domains 2 (Smco2), transcript variant X2, mRNA","Q9DA21",535,0,"Single-pass membrane and coiled-coil domain-containing protein 2",".",".",".",".","pfam14992","TMCO5","TMCO5 family. The TMCO5 family includes human transmembrane and coiled-coil domain-containing proteins 5A and 5B.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000032461",0,0.04151333,6,0.385982629,0.107552328,-3.216889345,0.037207666,0.025195532,"down","yes","Bin2a","protein_coding","chr8:25248570-25287173:-","gi|564362841|ref|XP_006242799.1|",3402,0,"PREDICTED: beta-galactosidase-like protein isoform X1 [Rattus norvegicus]","gi|57222331|ref|NM_001009524.1|",2584,0,"Rattus norvegicus beta-galactosidase-like protein (Bin2a), mRNA","Q8IW92",597,0,"Beta-galactosidase-1-like protein 2","XF0840",342,{"v":5e-105,"d":"5.00E-105"},"COG1874","pfam01301","Glyco_hydro_35","Glycosyl hydrolases family 35.","GO:0005975|carbohydrate metabolic process;","GO:0005773|vacuole;","GO:0004565|beta-galactosidase activity;",".","."]
["ENSRNOG00000033397",0,0.04151333,6,0.385982629,0.107552328,-3.216889345,0.037207666,0.025195532,"down","yes","Adamts20","protein_coding","chr7:125397734-125527777:-","gi|28804249|emb|CAD54808.3|",9380,0,"metalloprotease-disintegrin protease [Mus musculus]","gi|755551507|ref|XM_011245594.1|",4397,0,"PREDICTED: Mus musculus a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20 (Adamts20), transcript variant X6, mRNA","P59511",3617,0,"A disintegrin and metalloproteinase with thrombospondin motifs 20",".",".",".",".","pfam08685","GON","GON domain. The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) family of proteins. It contains several conserved cysteine residues.","GO:0006508|proteolysis;GO:0009967|positive regulation of signal transduction;GO:0030198|extracellular matrix organization;GO:0043066|negative regulation of apoptotic process;GO:0045636|positive regulation of melanocyte differentiation;GO:0048070|regulation of developmental pigmentation;","GO:0005615|extracellular space;GO:0031012|extracellular matrix;","GO:0004175|endopeptidase activity;GO:0004222|metalloendopeptidase activity;GO:0008270|zinc ion binding;","K09609","ADAMTS20; a disintegrin and metalloproteinase with thrombospondin motifs 20 [EC:3.4.24.-]"]
["ENSRNOG00000033981",0,0.04151333,6,0.385982629,0.107552328,-3.216889345,0.037207666,0.025195532,"down","yes","ENSRNOG00000033981","protein_coding","chr8:34024114-34050517:+","gi|74195000|dbj|BAE26067.1|",609,{"v":3e-78,"d":"3.00E-78"},"unnamed protein product [Mus musculus]","gi|74194999|dbj|AK144787.1|",290,{"v":7e-149,"d":"7.00E-149"},"Mus musculus lung RCB-0558 LLC cDNA, RIKEN full-length enriched library, clone:G730034J08 product:hypothetical protein, full insert sequence","Q3UW31",173,{"v":2e-54,"d":"2.00E-54"},"Prostate and testis expressed protein 2",".",".",".",".","pfam00858","ASC","Amiloride-sensitive sodium channel.",".","GO:0005615|extracellular space;",".","K25370","PATE; prostate and testis expressed protein"]
["ENSRNOG00000037481",0,0.04151333,6,0.385982629,0.107552328,-3.216889345,0.037207666,0.025195532,"down","yes","AC095390.1","protein_coding","chr12:45908683-45909048:-","gi|157819229|ref|NP_001100054.1|",600,{"v":1e-77,"d":"1.00E-77"},"replication protein A 14 kDa subunit [Rattus norvegicus]","gi|33342292|gb|AC095390.9|",366,0,"Rattus norvegicus 12 BAC CH230-7C24 (Children's Hospital Oakland Research Institute) complete sequence","Q9CQ71",222,{"v":8e-74,"d":"8.00E-74"},"Replication protein A 14 kDa subunit",".",".",".",".","pfam08661","Rep_fac-A_3","Replication factor A protein 3. Replication factor A is involved in eukaryotic DNA replication, recombination and repair.",".",".",".",".","."]
["ENSRNOG00000047175",0,0.04151333,6,0.385982629,0.107552328,-3.216889345,0.037207666,0.025195532,"down","yes","Cryaa","pseudogene","chr20:9783605-9787349:+","gi|19526477|ref|NP_036666.2|",814,{"v":2e-105,"d":"2.00E-105"},"alpha-crystallin A chain isoform 1 [Rattus norvegicus]","gi|576583437|ref|NM_012534.4|",1060,0,"Rattus norvegicus crystallin, alpha A (Cryaa), transcript variant 1, mRNA","P68406",318,{"v":7e-107,"d":"7.00E-107"},"Alpha-crystallin A chain",".",".",".",".","pfam00011","HSP20","Hsp20/alpha crystallin family.","GO:0001666|response to hypoxia;GO:0001934|positive regulation of protein phosphorylation;GO:0002088|lens development in camera-type eye;GO:0002089|lens morphogenesis in camera-type eye;GO:0006457|protein folding;GO:0006915|apoptotic process;GO:0007005|mitochondrion organization;GO:0007015|actin filament organization;GO:0007017|microtubule-based process;GO:0007021|tubulin complex assembly;GO:0007601|visual perception;GO:0009410|response to xenobiotic stimulus;GO:0010259|multicellular organism aging;GO:0010288|response to lead ion;GO:0010629|negative regulation of gene expression;GO:0030307|positive regulation of cell growth;GO:0032387|negative regulation of intracellular transport;GO:0042542|response to hydrogen peroxide;GO:0043010|camera-type eye development;GO:0043066|negative regulation of apoptotic process;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0048596|embryonic camera-type eye morphogenesis;GO:0050821|protein stabilization;GO:0051384|response to glucocorticoid;GO:0060561|apoptotic process involved in morphogenesis;GO:0070141|response to UV-A;GO:0070309|lens fiber cell morphogenesis;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0032991|protein-containing complex;","GO:0005198|structural molecule activity;GO:0005212|structural constituent of eye lens;GO:0005515|protein binding;GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0051082|unfolded protein binding;","K09541","CRYAA; crystallin, alpha A"]
["ENSRNOG00000049853",0,0.04151333,6,0.385982629,0.107552328,-3.216889345,0.037207666,0.025195532,"down","yes","ENSRNOG00000049853","protein_coding","chrX:106714868-106719794:+","gi|564323200|ref|XP_003754878.2|",6617,0,"PREDICTED: retrotransposon gag domain-containing protein 1 [Rattus norvegicus]","gi|672032662|ref|XM_008758535.1|",4333,0,"PREDICTED: Rattus norvegicus retrotransposon gag domain containing 1 (LOC100912526), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam05109","Herpes_BLLF1","Herpes virus major outer envelope glycoprotein (BLLF1). This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralizing antibodies in vivo.",".",".",".",".","."]
["ENSRNOG00000050761",0,0.04151333,6,0.385982629,0.107552328,-3.216889345,0.037207666,0.025195532,"down","yes","Serpina10","protein_coding","chr6:122756108-122764544:-","gi|56961653|ref|NP_598301.2|",2256,0,"protein Z-dependent protease inhibitor precursor [Rattus norvegicus]","gi|672057051|ref|XM_003750227.3|",1596,0,"PREDICTED: Rattus norvegicus protein Z-dependent protease inhibitor-like (LOC100909524), transcript variant X1, mRNA","Q62975",873,0,"Protein Z-dependent protease inhibitor","all0778",132,{"v":2e-33,"d":"2.00E-33"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0007596|blood coagulation;GO:0010951|negative regulation of endopeptidase activity;GO:0097421|liver regeneration;","GO:0005575|cellular_component;GO:0005615|extracellular space;","GO:0003674|molecular_function;GO:0004867|serine-type endopeptidase inhibitor activity;GO:0008201|heparin binding;","K04525","SERPINA; serpin A"]
["ENSRNOG00000051993",0,0.04151333,6,0.385982629,0.107552328,-3.216889345,0.037207666,0.025195532,"down","yes","Gdf10","protein_coding","chr16:9237261-9249343:+","gi|26335263|dbj|BAC31332.1|",2421,0,"unnamed protein product [Mus musculus]","gi|13242276|ref|NM_024375.1|",2408,0,"Rattus norvegicus growth differentiation factor 10 (Gdf10), mRNA","P55108",924,0,"Growth/differentiation factor 10",".",".",".",".","pfam00019","TGF_beta","Transforming growth factor beta like domain.","GO:0001649|osteoblast differentiation;GO:0007165|signal transduction;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0021549|cerebellum development;GO:0030278|regulation of ossification;GO:0042698|ovulation cycle;GO:0045444|fat cell differentiation;GO:0045668|negative regulation of osteoblast differentiation;GO:0045669|positive regulation of osteoblast differentiation;GO:0060395|SMAD protein signal transduction;GO:0071559|response to transforming growth factor beta;","GO:0005615|extracellular space;","GO:0005125|cytokine activity;GO:0008083|growth factor activity;","K22674","GDF10, BMP3B; growth differentiation factor 10"]
["ENSRNOG00000053259",0,0.04151333,6,0.385982629,0.107552328,-3.216889345,0.037207666,0.025195532,"down","yes","AC109844.1","protein_coding","chr1:195912167-195915668:+","gi|37654256|gb|AAQ96233.1|",705,{"v":4e-93,"d":"4.00E-93"},"LRRGT00020 [Rattus norvegicus]","gi|37654255|gb|AY383675.1|",402,0,"Rattus norvegicus LRRGT00020 mRNA, complete cds","P11260",75.1,{"v":2e-15,"d":"2.00E-15"},"LINE-1 retrotransposable element ORF1 protein",".",".",".",".","pfam02994","Transposase_22","L1 transposable element.",".",".",".",".","."]
["ENSRNOG00000058692",0,0.04151333,6,0.385982629,0.107552328,-3.216889345,0.037207666,0.025195532,"down","yes","Slc26a4","protein_coding","chr6:48107588-48145703:-","gi|9506965|ref|NP_062087.1|",3275,0,"pendrin [Rattus norvegicus]","gi|672055748|ref|XM_008764576.1|",2853,0,"PREDICTED: Rattus norvegicus solute carrier family 26 (anion exchanger), member 4 (Slc26a4), transcript variant X1, mRNA","Q9R154",1266,0,"Pendrin","SPAC869.05c",152,{"v":5e-37,"d":"5.00E-37"},"COG0659","pfam00916","Sulfate_transp","Sulfate transporter family. Mutations in human SLC26A2 lead to several human diseases.","GO:0006885|regulation of pH;GO:0015698|inorganic anion transport;GO:0015701|bicarbonate transport;GO:0015705|iodide transport;GO:0019532|oxalate transport;GO:0032880|regulation of protein localization;GO:1902358|sulfate transmembrane transport;GO:1902476|chloride transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0016324|apical plasma membrane;GO:0031526|brush border membrane;GO:0070062|extracellular exosome;","GO:0008271|secondary active sulfate transmembrane transporter activity;GO:0015106|bicarbonate transmembrane transporter activity;GO:0015108|chloride transmembrane transporter activity;GO:0015111|iodide transmembrane transporter activity;GO:0015116|sulfate transmembrane transporter activity;GO:0015301|anion:anion antiporter activity;GO:0019531|oxalate transmembrane transporter activity;","K14702","SLC26A4, PDS; solute carrier family 26 (sodium-independent chloride/iodide transporter), member 4"]
["ENSRNOG00000059798",0,0.04151333,6,0.385982629,0.107552328,-3.216889345,0.037207666,0.025195532,"down","yes","U6","snRNA","chr5:158992110-158992191:+",".",".",".",".","gi|323462216|gb|AC242221.3|",34,2e-07,"Tupaia belangeri clone CH275-105K19, complete sequence",".",".",".",".",".",".",".",".","pfam03376","Adeno_E3B","Adenovirus E3B protein.",".",".",".",".","."]
["ENSRNOG00000061530",0,0.04151333,6,0.385982629,0.107552328,-3.216889345,0.037207666,0.025195532,"down","yes","ENSRNOG00000061530","protein_coding","chrX:70817433-70878717:+","gi|11177916|ref|NP_068639.1|",1086,{"v":2e-143,"d":"2.00E-143"},"fibroblast growth factor 16 [Rattus norvegicus]","gi|55250401|gb|BC085738.1|",1630,0,"Rattus norvegicus fibroblast growth factor 16, mRNA (cDNA clone MGC:93457 IMAGE:7189721), complete cds","O54769",422,{"v":6e-145,"d":"6.00E-145"},"Fibroblast growth factor 16",".",".",".",".","pfam00167","FGF","Fibroblast growth factor. Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide range of contexts. They are found in a wide range of organisms, from nematodes to humans. Most share an internal core region of high similarity, conserved residues in which are involved in binding with their receptors. On binding, they cause dimerization of their tyrosine kinase receptors leading to intracellular signalling. There are currently four known tyrosine kinase receptors for fibroblast growth factors. These receptors can each bind several different members of this family. Members of this family have a beta trefoil structure. Most have N-terminal signal peptides and are secreted. A few lack signal sequences but are secreted anyway; still others also lack the signal peptide but are found on the cell surface and within the extracellular matrix. A third group remain intracellular. They have central roles in development, regulating cell proliferation, migration and differentiation. On the other hand, they are important in tissue repair following injury in adult organisms.","GO:0001934|positive regulation of protein phosphorylation;GO:0008284|positive regulation of cell proliferation;GO:0008543|fibroblast growth factor receptor signaling pathway;GO:0009887|animal organ morphogenesis;GO:0010628|positive regulation of gene expression;GO:0030154|cell differentiation;GO:0030334|regulation of cell migration;GO:0070349|positive regulation of brown fat cell proliferation;GO:2000546|positive regulation of endothelial cell chemotaxis to fibroblast growth factor;","GO:0005615|extracellular space;GO:0005737|cytoplasm;","GO:0005104|fibroblast growth factor receptor binding;GO:0008083|growth factor activity;","K04358","FGF; fibroblast growth factor"]
["ENSRNOG00000065910",0,0.04151333,6,0.385982629,0.107552328,-3.216889345,0.037207666,0.025195532,"down","yes","ENSRNOG00000065910","lncRNA","chr1:143276338-143279805:-","gi|755523156|ref|XP_011240215.1|",312,{"v":2e-28,"d":"2.00E-28"},"PREDICTED: transmembrane protein 135 isoform X4 [Mus musculus]","gi|38678662|gb|AC116326.5|",1187,0,"Mus musculus BAC clone RP24-64C6 from chromosome 7, complete sequence",".",".",".",".",".",".",".",".","pfam09407","DUF2005","Protein of unknown function (DUF2005). This is a family of proteins with unknown function.",".",".",".",".","."]
["ENSRNOG00000068163",0,0.04151333,6,0.385982629,0.107552328,-3.216889345,0.037207666,0.025195532,"down","yes","ENSRNOG00000068163","protein_coding","chr20:13475804-13476849:+","gi|931610396|ref|XP_014198725.1|",251,{"v":9e-26,"d":"9.00E-26"},"PREDICTED: active breakpoint cluster region-related protein-like isoform X2 [Pan paniscus]","gi|354794624|gb|JN959125.1|",157,{"v":4e-75,"d":"4.00E-75"},"Mus musculus targeted deletion, lacZ-tagged mutant allele Bcr:tm1(KOMP)Wtsi; transgenic","Q6PAJ1",94.4,{"v":1e-21,"d":"1.00E-21"},"Breakpoint cluster region protein",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.",".",".",".",".","."]
["ENSRNOG00000068990",0,0.04151333,6,0.385982629,0.107552328,-3.216889345,0.037207666,0.025195532,"down","yes","Olr161","protein_coding","chr1:158941776-158944225:+","gi|47576505|ref|NP_001001000.1|",1549,0,"olfactory receptor Olr161 [Rattus norvegicus]","gi|90855788|gb|AC128039.4|",1253,0,"Rattus norvegicus BAC CH230-394A24 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q8NGI1",507,{"v":4E-176,"d":"4.00E-176"},"Putative olfactory receptor 56B2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.",".",".",".",".","."]
["ENSRNOG00000069844",0,0.04151333,6,0.385982629,0.107552328,-3.216889345,0.037207666,0.025195532,"down","yes","ENSRNOG00000069844","lncRNA","chr13:92304945-92307559:-",".",".",".",".","gi|56847|emb|X65496.1|",236,{"v":2E-118,"d":"2.00E-118"},"R.norvegicus gene for poly(ADP-ribose) polymerase (clone pGrat5')",".",".",".",".",".",".",".",".","pfam03838","RecU","Recombination protein U.",".",".",".",".","."]
["ENSRNOG00000070466",0,0.04151333,6,0.385982629,0.107552328,-3.216889345,0.037207666,0.025195532,"down","yes","ENSRNOG00000070466","pseudogene","chr9:15260659-15261424:+","gi|148691515|gb|EDL23462.1|",341,{"v":4e-39,"d":"4.00E-39"},"mCG147804 [Mus musculus]","gi|755559088|ref|XM_006524968.2|",222,{"v":3e-111,"d":"3.00E-111"},"PREDICTED: Mus musculus RIKEN cDNA 1600014C23 gene (1600014C23Rik), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam15242","FAM53","Family of FAM53. The FAM53 protein family refers to a family of proteins, which bind to a transcriptional regulator that modulates cell proliferation. It is known to be highly important in neural tube development. It is found in eukaryotes and is typically between 303 and 413 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000004473",6,0.498159963,19,1.222278326,0.407566716,-1.294891857,0.037319865,0.025235665,"down","yes","Ppargc1a","protein_coding","chr14:58861144-59512656:+","gi|672076432|ref|XP_008768441.1|",2672,0,"PREDICTED: peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [Rattus norvegicus]","gi|880877600|ref|XM_005068780.2|",2538,0,"PREDICTED: Mesocricetus auratus peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (Ppargc1a), transcript variant X2, mRNA","Q9QYK2",1031,0,"Peroxisome proliferator-activated receptor gamma coactivator 1-alpha",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0000302|response to reactive oxygen species;GO:0000422|autophagy of mitochondrion;GO:0001666|response to hypoxia;GO:0001933|negative regulation of protein phosphorylation;GO:0002021|response to dietary excess;GO:0002931|response to ischemia;GO:0006012|galactose metabolic process;GO:0006094|gluconeogenesis;GO:0006355|regulation of transcription, DNA-templated;GO:0007005|mitochondrion organization;GO:0007568|aging;GO:0008209|androgen metabolic process;GO:0009409|response to cold;GO:0009410|response to xenobiotic stimulus;GO:0009750|response to fructose;GO:0010628|positive regulation of gene expression;GO:0010822|positive regulation of mitochondrion organization;GO:0014070|response to organic cyclic compound;GO:0014732|skeletal muscle atrophy;GO:0014823|response to activity;GO:0014850|response to muscle activity;GO:0014878|response to electrical stimulus involved in regulation of muscle adaptation;GO:0014912|negative regulation of smooth muscle cell migration;GO:0019395|fatty acid oxidation;GO:0021549|cerebellum development;GO:0022904|respiratory electron transport chain;GO:0030900|forebrain development;GO:0031325|positive regulation of cellular metabolic process;GO:0031667|response to nutrient levels;GO:0032922|circadian regulation of gene expression;GO:0034599|cellular response to oxidative stress;GO:0035865|cellular response to potassium ion;GO:0042594|response to starvation;GO:0042752|regulation of circadian rhythm;GO:0043201|response to leucine;GO:0043524|negative regulation of neuron apoptotic process;GO:0045820|negative regulation of glycolytic process;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046321|positive regulation of fatty acid oxidation;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0048662|negative regulation of smooth muscle cell proliferation;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051552|flavone metabolic process;GO:0051602|response to electrical stimulus;GO:0060612|adipose tissue development;GO:0071222|cellular response to lipopolysaccharide;GO:0071250|cellular response to nitrite;GO:0071313|cellular response to caffeine;GO:0071332|cellular response to fructose stimulus;GO:0071333|cellular response to glucose stimulus;GO:0071354|cellular response to interleukin-6;GO:0071356|cellular response to tumor necrosis factor;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0071392|cellular response to estradiol stimulus;GO:0071398|cellular response to fatty acid;GO:0071456|cellular response to hypoxia;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0071871|response to epinephrine;GO:0071873|response to norepinephrine;GO:0090258|negative regulation of mitochondrial fission;GO:0097009|energy homeostasis;GO:0097066|response to thyroid hormone;GO:0097067|cellular response to thyroid hormone stimulus;GO:0120162|positive regulation of cold-induced thermogenesis;GO:1901215|negative regulation of neuron death;GO:1901558|response to metformin;GO:1901857|positive regulation of cellular respiration;GO:1901860|positive regulation of mitochondrial DNA metabolic process;GO:1901863|positive regulation of muscle tissue development;GO:1904635|positive regulation of glomerular visceral epithelial cell apoptotic process;GO:1904637|cellular response to ionomycin;GO:1904639|cellular response to resveratrol;GO:1904640|response to methionine;GO:1990845|adaptive thermogenesis;GO:2000184|positive regulation of progesterone biosynthetic process;GO:2000272|negative regulation of signaling receptor activity;GO:2000310|regulation of NMDA receptor activity;GO:2001171|positive regulation of ATP biosynthetic process;","GO:0000791|euchromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;GO:0016605|PML body;GO:0022626|cytosolic ribosome;GO:0043025|neuronal cell body;GO:0043231|intracellular membrane-bounded organelle;GO:0097440|apical dendrite;","GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003713|transcription coactivator activity;GO:0003723|RNA binding;GO:0005515|protein binding;GO:0008134|transcription factor binding;GO:0016922|nuclear receptor binding;GO:0030331|estrogen receptor binding;GO:0030374|nuclear receptor transcription coactivator activity;GO:0031490|chromatin DNA binding;GO:0031625|ubiquitin protein ligase binding;GO:0042975|peroxisome proliferator activated receptor binding;GO:0043014|alpha-tubulin binding;GO:0043565|sequence-specific DNA binding;GO:1990841|promoter-specific chromatin binding;","K07202","PPARGC1A, PGC1A; alpha peroxisome proliferator-activated receptor gamma coactivator 1-alpha"]
["ENSRNOG00000009773",6,0.498159963,19,1.222278326,0.407566716,-1.294891857,0.037319865,0.025235665,"down","yes","Elovl4","protein_coding","chr8:84702362-84729697:-","gi|300796614|ref|NP_001178725.1|",1649,0,"elongation of very long chain fatty acids protein 4 [Rattus norvegicus]","gi|880899996|ref|XM_005073689.2|",949,0,"PREDICTED: Mesocricetus auratus ELOVL fatty acid elongase 4 (Elovl4), mRNA","Q9EQC4",620,0,"Elongation of very long chain fatty acids protein 4",".",".",".",".","pfam01151","ELO","GNS1/SUR4 family. Members of this family are involved in long chain fatty acid elongation systems that produce the 26-carbon precursors for ceramide and sphingolipid synthesis. Predicted to be integral membrane proteins, in eukaryotes they are probably located on the endoplasmic reticulum. Yeast ELO3 affects plasma membrane H+-ATPase activity, and may act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1.","GO:0006636|unsaturated fatty acid biosynthetic process;GO:0008150|biological_process;GO:0019367|fatty acid elongation, saturated fatty acid;GO:0030148|sphingolipid biosynthetic process;GO:0034625|fatty acid elongation, monounsaturated fatty acid;GO:0034626|fatty acid elongation, polyunsaturated fatty acid;GO:0035338|long-chain fatty-acyl-CoA biosynthetic process;GO:0042761|very long-chain fatty acid biosynthetic process;","GO:0005575|cellular_component;GO:0005783|endoplasmic reticulum;GO:0030176|integral component of endoplasmic reticulum membrane;","GO:0003674|molecular_function;GO:0009922|fatty acid elongase activity;GO:0102336|3-oxo-arachidoyl-CoA synthase activity;GO:0102337|3-oxo-cerotoyl-CoA synthase activity;GO:0102338|3-oxo-lignoceronyl-CoA synthase activity;GO:0102756|very-long-chain 3-ketoacyl-CoA synthase activity;","K10249","ELOVL4; elongation of very long chain fatty acids protein 4 [EC:2.3.1.199]"]
["ENSRNOG00000020985",6,0.498159963,19,1.222278326,0.407566716,-1.294891857,0.037319865,0.025235665,"down","yes","Atp4a","protein_coding","chr1:85961708-85974844:+","gi|281306811|ref|NP_036641.1|",5271,0,"potassium-transporting ATPase alpha chain 1 [Rattus norvegicus]","gi|203036|gb|J02649.1|RATATPAST",3383,0,"Rat stomach (H+,K+)-ATPase mRNA, complete cds","P09626",2027,0,"Potassium-transporting ATPase alpha chain 1","MA4378",627,0,"COG0474","pfam00122","E1-E2_ATPase","E1-E2 ATPase.","GO:0001696|gastric acid secretion;GO:0006883|cellular sodium ion homeostasis;GO:0009410|response to xenobiotic stimulus;GO:0010155|regulation of proton transport;GO:0010248|establishment or maintenance of transmembrane electrochemical gradient;GO:0030007|cellular potassium ion homeostasis;GO:0036376|sodium ion export across plasma membrane;GO:0045851|pH reduction;GO:0071805|potassium ion transmembrane transport;GO:1902600|proton transmembrane transport;GO:1990573|potassium ion import across plasma membrane;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;","GO:0000287|magnesium ion binding;GO:0005391|sodium:potassium-exchanging ATPase activity;GO:0005524|ATP binding;GO:0008900|potassium:proton exchanging ATPase activity;GO:0030955|potassium ion binding;","K01542","ATP4A; H+/K+-exchanging ATPase subunit alpha [EC:7.2.2.19]"]
["ENSRNOG00000028992",6,0.498159963,19,1.222278326,0.407566716,-1.294891857,0.037319865,0.025235665,"down","yes","Acan","protein_coding","chr1:132981582-133043627:+","gi|149057245|gb|EDM08568.1|",9991,0,"aggrecan 1, isoform CRA_a [Rattus norvegicus]","gi|11990615|ref|NM_022190.1|",6906,0,"Rattus norvegicus aggrecan (Acan), mRNA","P07897",3735,0,"Aggrecan core protein",".",".",".",".","pfam00193","Xlink","Extracellular link domain.","GO:0001501|skeletal system development;GO:0001502|cartilage condensation;GO:0001503|ossification;GO:0002063|chondrocyte development;GO:0007155|cell adhesion;GO:0007417|central nervous system development;GO:0007507|heart development;GO:0009314|response to radiation;GO:0009410|response to xenobiotic stimulus;GO:0009612|response to mechanical stimulus;GO:0009629|response to gravity;GO:0009749|response to glucose;GO:0010259|multicellular organism aging;GO:0010447|response to acidic pH;GO:0014070|response to organic cyclic compound;GO:0021510|spinal cord development;GO:0030166|proteoglycan biosynthetic process;GO:0030199|collagen fibril organization;GO:0030336|negative regulation of cell migration;GO:0060591|chondroblast differentiation;GO:0071363|cellular response to growth factor stimulus;","GO:0005576|extracellular region;GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0031012|extracellular matrix;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0072534|perineuronal net;GO:0098966|perisynaptic extracellular matrix;GO:0098978|glutamatergic synapse;GO:0098982|GABA-ergic synapse;","GO:0005509|calcium ion binding;GO:0005540|hyaluronic acid binding;GO:0030246|carbohydrate binding;","K06792","AGC1, CSPG1; aggrecan 1"]
["ENSRNOG00000030910",6,0.498159963,19,1.222278326,0.407566716,-1.294891857,0.037319865,0.025235665,"down","yes","Grik4","protein_coding","chr8:42905056-43193751:-","gi|10242377|ref|NP_036704.1|",5007,0,"glutamate receptor ionotropic, kainate 4 precursor [Rattus norvegicus]","gi|10242376|ref|NM_012572.1|",3237,0,"Rattus norvegicus glutamate ionotropic receptor kainate type subunit 4 (Grik4), mRNA","Q01812",1926,0,"Glutamate receptor ionotropic, kainate 4","TM0593",55.8,2e-07,"COG0834","pfam00060","Lig_chan","Ligand-gated ion channel. This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.","GO:0006811|ion transport;GO:0007268|chemical synaptic transmission;GO:0031960|response to corticosteroid;GO:0034220|ion transmembrane transport;GO:0035235|ionotropic glutamate receptor signaling pathway;GO:0035249|synaptic transmission, glutamatergic;GO:0050804|modulation of chemical synaptic transmission;GO:0060078|regulation of postsynaptic membrane potential;","GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0008328|ionotropic glutamate receptor complex;GO:0016020|membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0032983|kainate selective glutamate receptor complex;GO:0042734|presynaptic membrane;GO:0043195|terminal bouton;GO:0043204|perikaryon;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0098686|hippocampal mossy fiber to CA3 synapse;GO:0098978|glutamatergic synapse;GO:0099055|integral component of postsynaptic membrane;GO:0099056|integral component of presynaptic membrane;","GO:0004970|ionotropic glutamate receptor activity;GO:0008066|glutamate receptor activity;GO:0015276|ligand-gated ion channel activity;GO:0015277|kainate selective glutamate receptor activity;GO:0038023|signaling receptor activity;GO:1904315|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K05204","GRIK4; glutamate receptor, ionotropic kainate 4"]
["ENSRNOG00000060401",6,0.498159963,19,1.222278326,0.407566716,-1.294891857,0.037319865,0.025235665,"down","yes","Dusp13","protein_coding","chr15:2533547-2575539:+","gi|672077367|ref|XP_008768696.1|",1385,{"v":3E-176,"d":"3.00E-176"},"PREDICTED: dual specificity protein phosphatase 13 isoform B isoform X1 [Rattus norvegicus]","gi|672077368|ref|XM_003751425.3|",1067,0,"PREDICTED: Rattus norvegicus dual specificity protein phosphatase 13-like (LOC100909469), transcript variant X2, mRNA","Q9QYJ7",400,{"v":3e-128,"d":"3.00E-128"},"Dual specificity protein phosphatase 13 isoform B","SPBC17A3.06",58.5,5e-08,"COG2453","pfam00782","DSPc","Dual specificity phosphatase, catalytic domain. Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a \"recognition\" region.","GO:0016311|dephosphorylation;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0043409|negative regulation of MAPK cascade;","GO:0005737|cytoplasm;GO:0016021|integral component of membrane;","GO:0004725|protein tyrosine phosphatase activity;GO:0008138|protein tyrosine/serine/threonine phosphatase activity;GO:0016791|phosphatase activity;GO:0033549|MAP kinase phosphatase activity;","K14165","K14165; atypical dual specificity phosphatase [EC:3.1.3.16 3.1.3.48]"]
["ENSRNOG00000065346",6,0.498159963,19,1.222278326,0.407566716,-1.294891857,0.037319865,0.025235665,"down","yes","ENSRNOG00000065346","lncRNA","chr1:127609383-127628539:+","gi|1002594062|ref|XP_015675905.1|",262,{"v":5e-24,"d":"5.00E-24"},"PREDICTED: protein ZBED8-like [Protobothrops mucrosquamatus]","gi|672013853|ref|XR_598929.1|",865,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103691163 (LOC103691163), ncRNA",".",".",".",".",".",".",".",".","pfam03154","Atrophin-1","Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.",".",".",".",".","."]
["ENSRNOG00000011917",2,0.166053321,10,0.643304382,0.258125587,-1.953854939,0.042012343,0.028011604,"down","yes","Cd79b","protein_coding","chr10:91239356-91242625:-","gi|149054577|gb|EDM06394.1|",1019,{"v":2E-132,"d":"2.00E-132"},"CD79B antigen [Rattus norvegicus]","gi|298914808|emb|FQ232790.1|",610,0,"Rattus norvegicus TL0AEA64YG17 mRNA sequence","P15530",262,{"v":1e-82,"d":"1.00E-82"},"B-cell antigen receptor complex-associated protein beta chain",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0002250|adaptive immune response;GO:0008150|biological_process;GO:0009617|response to bacterium;GO:0030183|B cell differentiation;GO:0050853|B cell receptor signaling pathway;","GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0019815|B cell receptor complex;","GO:0003674|molecular_function;GO:0004888|transmembrane signaling receptor activity;GO:0042802|identical protein binding;","K06507","CD79B, IGB; CD79B antigen"]
["ENSRNOG00000013734",2,0.166053321,10,0.643304382,0.258125587,-1.953854939,0.042012343,0.028011604,"down","yes","Dnai1","protein_coding","chr5:56730179-56800925:+","gi|66730473|ref|NP_001019513.1|",3545,0,"dynein intermediate chain 1, axonemal [Rattus norvegicus]","gi|66730472|ref|NM_001024342.1|",2406,0,"Rattus norvegicus dynein, axonemal, intermediate chain 1 (Dnai1), mRNA","Q5XIL8",1364,0,"Dynein intermediate chain 1, axonemal",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.","GO:0003341|cilium movement;GO:0003351|epithelial cilium movement;GO:0007018|microtubule-based movement;GO:0007368|determination of left/right symmetry;GO:0007507|heart development;GO:0008150|biological_process;GO:0008286|insulin receptor signaling pathway;GO:0030317|flagellated sperm motility;GO:0036158|outer dynein arm assembly;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0005874|microtubule;GO:0005929|cilium;GO:0036157|outer dynein arm;GO:0097729|9+2 motile cilium;","GO:0005515|protein binding;GO:0045503|dynein light chain binding;GO:0045504|dynein heavy chain binding;","K10409","DNAI1; dynein axonemal intermediate chain 1"]
["ENSRNOG00000017725",2,0.166053321,10,0.643304382,0.258125587,-1.953854939,0.042012343,0.028011604,"down","yes","Pnlip","protein_coding","chr1:257798581-257811654:+","gi|149040500|gb|EDL94538.1|",2514,0,"pancreatic lipase, isoform CRA_a [Rattus norvegicus]","gi|402692544|ref|NM_013161.2|",1439,0,"Rattus norvegicus pancreatic lipase (Pnlip), mRNA","P27657",967,0,"Pancreatic triacylglycerol lipase",".",".",".",".","pfam00151","Lipase","Lipase.","GO:0006629|lipid metabolic process;GO:0009791|post-embryonic development;GO:0016042|lipid catabolic process;GO:0030299|intestinal cholesterol absorption;GO:0033993|response to lipid;GO:0042572|retinol metabolic process;GO:0043434|response to peptide hormone;GO:0061365|positive regulation of triglyceride lipase activity;","GO:0005615|extracellular space;","GO:0004806|triglyceride lipase activity;GO:0016298|lipase activity;GO:0046872|metal ion binding;GO:0047376|all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity;","K14073","PNLIP, PL; pancreatic triacylglycerol lipase [EC:3.1.1.3]"]
["ENSRNOG00000024221",2,0.166053321,10,0.643304382,0.258125587,-1.953854939,0.042012343,0.028011604,"down","yes","Mettl24","protein_coding","chr20:44142396-44261310:+","gi|68163513|ref|NP_001020209.1|",1628,0,"methyltransferase-like protein 24 precursor [Rattus norvegicus]","gi|68163512|ref|NM_001025038.1|",1418,0,"Rattus norvegicus methyltransferase like 24 (Mettl24), mRNA","Q5BK01",631,0,"Methyltransferase-like protein 24",".",".",".",".","pfam13383","Methyltransf_22","Methyltransferase domain. This family appears to be a methyltransferase domain.","GO:0032259|methylation;","GO:0005576|extracellular region;","GO:0008168|methyltransferase activity;",".","."]
["ENSRNOG00000029876",2,0.166053321,10,0.643304382,0.258125587,-1.953854939,0.042012343,0.028011604,"down","yes","ENSRNOG00000029876","protein_coding","chr8:500212-889203:+","gi|13027400|ref|NP_076446.1|",2716,0,"guanylate cyclase soluble subunit alpha-2 [Rattus norvegicus]","gi|13027399|ref|NM_023956.1|",1812,0,"Rattus norvegicus guanylate cyclase 1, soluble, alpha 2 (Gucy1a2), mRNA","Q9WVI4",1050,0,"Guanylate cyclase soluble subunit alpha-2","all0661",63.2,2e-09,"COG2114","pfam07701","HNOBA","Heme NO binding associated. The HNOBA domain is found associated with the HNOB domain and pfam00211 in soluble cyclases and signalling proteins. The HNOB domain is predicted to function as a heme-dependent sensor for gaseous ligands, and transduce diverse downstream signals, in both bacteria and animals.","GO:0006182|cGMP biosynthetic process;GO:0010750|positive regulation of nitric oxide mediated signal transduction;GO:0035556|intracellular signal transduction;","GO:0005829|cytosol;","GO:0004383|guanylate cyclase activity;GO:0005515|protein binding;GO:0005525|GTP binding;GO:0020037|heme binding;GO:0044877|protein-containing complex binding;","K12318","GUCY1A; guanylate cyclase soluble subunit alpha [EC:4.6.1.2]"]
["ENSRNOG00000033479",2,0.166053321,10,0.643304382,0.258125587,-1.953854939,0.042012343,0.028011604,"down","yes","Pcdhb21","protein_coding","chr18:29218225-29221142:+","gi|167736400|ref|NP_001108076.1|",3645,0,"protocadherin beta-11 [Rattus norvegicus]","gi|167736399|ref|NM_001114604.1|",2918,0,"Rattus norvegicus protocadherin beta 21 (Pcdhb21), mRNA","Q5DRD4",1080,0,"Protocadherin beta-18",".",".",".",".","pfam08266","Cadherin_2","Cadherin-like. This cadherin domain is usually the most N-terminal copy of the domain.","GO:0007155|cell adhesion;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005887|integral component of plasma membrane;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;","K16494","PCDHB; protocadherin beta"]
["ENSRNOG00000047466",2,0.166053321,10,0.643304382,0.258125587,-1.953854939,0.042012343,0.028011604,"down","yes","Bdnf","protein_coding","chr3:96165042-96215615:+","gi|397174766|ref|NP_036645.2|",1322,{"v":7e-168,"d":"7.00E-168"},"brain-derived neurotrophic factor isoform 2 preproprotein [Rattus norvegicus]","gi|397174765|ref|NM_012513.4|",4291,0,"Rattus norvegicus brain-derived neurotrophic factor (Bdnf), transcript variant 2, mRNA","P23363",497,{"v":4e-163,"d":"4.00E-163"},"Brain-derived neurotrophic factor",".",".",".",".","pfam00243","NGF","Nerve growth factor family.","GO:0001657|ureteric bud development;GO:0001662|behavioral fear response;GO:0001666|response to hypoxia;GO:0002544|chronic inflammatory response;GO:0006120|mitochondrial electron transport, NADH to ubiquinone;GO:0007165|signal transduction;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007214|gamma-aminobutyric acid signaling pathway;GO:0007399|nervous system development;GO:0007406|negative regulation of neuroblast proliferation;GO:0007411|axon guidance;GO:0007412|axon target recognition;GO:0007416|synapse assembly;GO:0007422|peripheral nervous system development;GO:0007568|aging;GO:0007611|learning or memory;GO:0007612|learning;GO:0007613|memory;GO:0007623|circadian rhythm;GO:0007631|feeding behavior;GO:0008038|neuron recognition;GO:0009410|response to xenobiotic stimulus;GO:0009416|response to light stimulus;GO:0009642|response to light intensity;GO:0009725|response to hormone;GO:0010832|negative regulation of myotube differentiation;GO:0010976|positive regulation of neuron projection development;GO:0010996|response to auditory stimulus;GO:0014047|glutamate secretion;GO:0014823|response to activity;GO:0016358|dendrite development;GO:0019222|regulation of metabolic process;GO:0021675|nerve development;GO:0030182|neuron differentiation;GO:0030516|regulation of axon extension;GO:0031099|regeneration;GO:0031667|response to nutrient levels;GO:0032094|response to food;GO:0032229|negative regulation of synaptic transmission, GABAergic;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0033189|response to vitamin A;GO:0034612|response to tumor necrosis factor;GO:0035864|response to potassium ion;GO:0038180|nerve growth factor signaling pathway;GO:0042490|mechanoreceptor differentiation;GO:0042596|fear response;GO:0043066|negative regulation of apoptotic process;GO:0043523|regulation of neuron apoptotic process;GO:0043524|negative regulation of neuron apoptotic process;GO:0045664|regulation of neuron differentiation;GO:0045666|positive regulation of neuron differentiation;GO:0045843|negative regulation of striated muscle tissue development;GO:0046668|regulation of retinal cell programmed cell death;GO:0048148|behavioral response to cocaine;GO:0048167|regulation of synaptic plasticity;GO:0048169|regulation of long-term neuronal synaptic plasticity;GO:0048170|positive regulation of long-term neuronal synaptic plasticity;GO:0048172|regulation of short-term neuronal synaptic plasticity;GO:0048668|collateral sprouting;GO:0048670|regulation of collateral sprouting;GO:0048672|positive regulation of collateral sprouting;GO:0048675|axon extension;GO:0048812|neuron projection morphogenesis;GO:0048839|inner ear development;GO:0050804|modulation of chemical synaptic transmission;GO:0050890|cognition;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051602|response to electrical stimulus;GO:0051965|positive regulation of synapse assembly;GO:0055093|response to hyperoxia;GO:0060079|excitatory postsynaptic potential;GO:0060080|inhibitory postsynaptic potential;GO:0060548|negative regulation of cell death;GO:0061193|taste bud development;GO:0071356|cellular response to tumor necrosis factor;GO:0071874|cellular response to norepinephrine stimulus;GO:0072347|response to anesthetic;GO:0097484|dendrite extension;GO:0099083|retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission;GO:1900122|positive regulation of receptor binding;GO:1901215|negative regulation of neuron death;GO:1902065|response to L-glutamate;GO:1990089|response to nerve growth factor;GO:1990090|cellular response to nerve growth factor stimulus;GO:1990138|neuron projection extension;GO:1990708|conditioned place preference;GO:2000324|positive regulation of glucocorticoid receptor signaling pathway;GO:2001234|negative regulation of apoptotic signaling pathway;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0008021|synaptic vesicle;GO:0016607|nuclear speck;GO:0030061|mitochondrial crista;GO:0030141|secretory granule;GO:0030424|axon;GO:0030425|dendrite;GO:0031410|cytoplasmic vesicle;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0043204|perikaryon;GO:0048471|perinuclear region of cytoplasm;GO:0098794|postsynapse;","GO:0005163|nerve growth factor receptor binding;GO:0005169|neurotrophin TRKB receptor binding;GO:0008083|growth factor activity;","K04355","BDNF; brain-derived neurotrophic factor"]
["ENSRNOG00000048875",2,0.166053321,10,0.643304382,0.258125587,-1.953854939,0.042012343,0.028011604,"down","yes","Znrf4","protein_coding","chr9:1353306-1354584:-","gi|148706223|gb|EDL38170.1|",1396,0,"zinc and ring finger 4, partial [Mus musculus]","gi|67846047|ref|NM_001024878.1|",1189,0,"Rattus norvegicus zinc and ring finger 4 (Znrf4), mRNA","Q9DAH2",433,{"v":6e-149,"d":"6.00E-149"},"E3 ubiquitin-protein ligase ZNRF4",".",".",".",".","pfam13639","zf-RING_2","Ring finger domain.","GO:0006511|ubiquitin-dependent protein catabolic process;GO:0016567|protein ubiquitination;","GO:0005737|cytoplasm;GO:0005789|endoplasmic reticulum membrane;","GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;","K15715","ZNRF4; E3 ubiquitin-protein ligase ZNRF4 [EC:2.3.2.27]"]
["ENSRNOG00000053969",2,0.166053321,10,0.643304382,0.258125587,-1.953854939,0.042012343,0.028011604,"down","yes","AABR07008681.1","protein_coding","chr2:60024969-60032699:-","gi|68235767|gb|AAY88222.1|",1965,0,"nucleic acid binding protein [Rattus norvegicus]","gi|31455630|gb|AC096039.7|",1562,0,"Rattus norvegicus 4 BAC CH230-29I22 (Children's Hospital Oakland Research Institute) complete sequence","P11260",471,{"v":2E-159,"d":"2.00E-159"},"LINE-1 retrotransposable element ORF1 protein",".",".",".",".","pfam02994","Transposase_22","L1 transposable element.",".",".",".",".","."]
["ENSRNOG00000061119",2,0.166053321,10,0.643304382,0.258125587,-1.953854939,0.042012343,0.028011604,"down","yes","AABR07016612.1","snoRNA","chr14:95975590-95975713:+",".",".",".",".","gi|908662847|tpe|LN872339.1|",94,{"v":2e-40,"d":"2.00E-40"},"TPA: Mus musculus SNORA19 (ACA19) gene for small nucleolar RNA SNORA19 (ACA19)",".",".",".",".",".",".",".",".","pfam01770","Folate_carrier","Reduced folate carrier. The reduced folate carrier (a transmembrane glycoprotein) transports reduced folate into mammalian cells via the carrier mediated mechanism (as opposed to the receptor mediated mechanism) it also transports cytotoxic folate analogues used in chemotherapy, such as methotrexate (MTX). Mammalian cells have an absolute requirement for exogenous folates which are needed for growth, and biosynthesis of macromolecules.",".",".",".",".","."]
["ENSRNOG00000061471",2,0.166053321,10,0.643304382,0.258125587,-1.953854939,0.042012343,0.028011604,"down","yes","Gm25744","snoRNA","chr20:3877283-3877346:+",".",".",".",".","gi|46237588|emb|BX883045.1|",64,{"v":3E-24,"d":"3.00E-24"},"Rattus norvegicus chromosome 20, major histocompatibility complex, assembled from 40 BACs, strain Brown Norway (BN/ssNHsd), RT1n haplotype; segment 4/11",".",".",".",".",".",".",".",".","pfam08900","DUF1845","Domain of unknown function (DUF1845). This family of proteins are functionally uncharacterized.",".",".",".",".","."]
["ENSRNOG00000062445",2,0.166053321,10,0.643304382,0.258125587,-1.953854939,0.042012343,0.028011604,"down","yes","ENSRNOG00000062445","lncRNA","chrX:20871338-20873731:+",".",".",".",".","gi|29125266|emb|AL954855.8|",201,{"v":2E-99,"d":"2.00E-99"},"Mouse DNA sequence from clone RP23-211L10 on chromosome X, complete sequence",".",".",".",".",".",".",".",".","pfam01500","Keratin_B2","Keratin, high sulfur B2 protein. High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.",".",".",".",".","."]
["ENSRNOG00000066037",2,0.166053321,10,0.643304382,0.258125587,-1.953854939,0.042012343,0.028011604,"down","yes","ENSRNOG00000066037","lncRNA","chr17:73347582-73350610:+",".",".",".",".","gi|49406050|gb|AC084310.16|",78,{"v":5e-31,"d":"5.00E-31"},"Mus musculus chromosome 1, clone RP23-10C10, complete sequence",".",".",".",".",".",".",".",".","pfam00710","Asparaginase","Asparaginase.",".",".",".",".","."]
["ENSRNOG00000069442",2,0.166053321,10,0.643304382,0.258125587,-1.953854939,0.042012343,0.028011604,"down","yes","U6","snRNA","chr8:71077846-71077952:-","gi|537152882|gb|ERE72362.1|",189,{"v":1e-16,"d":"1.00E-16"},"membralin-like protein [Cricetulus griseus]","gi|56461865|gb|AC115067.7|",107,{"v":7e-48,"d":"7.00E-48"},"Mus musculus chromosome 5, clone RP24-404B4, complete sequence",".",".",".",".",".",".",".",".","pfam00522","VPR","VPR/VPX protein.",".",".",".",".","."]
["ENSRNOG00000069764",2,0.166053321,10,0.643304382,0.258125587,-1.953854939,0.042012343,0.028011604,"down","yes","ENSRNOG00000069764","lncRNA","chr10:44643924-44647277:+","gi|545832712|ref|XP_005664893.1|",174,{"v":5e-10,"d":"5.00E-10"},"PREDICTED: endogenous retrovirus group 3 member 1 Env polyprotein-like [Sus scrofa]","gi|354799905|gb|JN964406.1|",387,0,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Cops3:tm1e(KOMP)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam10436","BCDHK_Adom3","Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase. Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal.",".",".",".",".","."]
["ENSRNOG00000015061",9,0.747239945,24,1.543930516,0.483985475,-1.046964343,0.048241864,0.031546685,"down","yes","Igfals","protein_coding","chr10:13898395-13902677:+","gi|149052066|gb|EDM03883.1|",2667,0,"insulin-like growth factor binding protein, acid labile subunit, isoform CRA_a [Rattus norvegicus]","gi|3093473|gb|AF006203.1|AF006203",2070,0,"Rattus norvegicus insulin-like growth factor binding protein complex acid-labile subunit gene, complete cds","P35859",1024,0,"Insulin-like growth factor-binding protein complex acid labile subunit","SPy1798",88.6,{"v":4e-17,"d":"4.00E-17"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0007155|cell adhesion;GO:0007568|aging;GO:0031667|response to nutrient levels;GO:0071347|cellular response to interleukin-1;GO:0071364|cellular response to epidermal growth factor stimulus;GO:0071378|cellular response to growth hormone stimulus;GO:0071549|cellular response to dexamethasone stimulus;","GO:0005615|extracellular space;GO:0031012|extracellular matrix;GO:0042567|insulin-like growth factor ternary complex;","GO:0005520|insulin-like growth factor binding;","K17256","IGFALS, ALS; insulin-like growth factor-binding protein complex acid labile subunit"]
["ENSRNOG00000004645",3,0.249079982,12,0.771965258,0.322656983,-1.631926844,0.049159966,0.032035663,"down","yes","Galnt5","protein_coding","chr3:42573622-42619881:+","gi|13929126|ref|NP_113984.1|",4938,0,"polypeptide N-acetylgalactosaminyltransferase 5 [Rattus norvegicus]","gi|13929125|ref|NM_031796.1|",3509,0,"Rattus norvegicus polypeptide N-acetylgalactosaminyltransferase 5 (Galnt5), mRNA","O88422",1906,0,"Polypeptide N-acetylgalactosaminyltransferase 5",".",".",".",".","pfam00535","Glycos_transf_2","Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.","GO:0006486|protein glycosylation;","GO:0000139|Golgi membrane;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;","GO:0004653|polypeptide N-acetylgalactosaminyltransferase activity;GO:0030246|carbohydrate binding;GO:0046872|metal ion binding;","K00710","GALNT; polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41]"]
["ENSRNOG00000013605",3,0.249079982,12,0.771965258,0.322656983,-1.631926844,0.049159966,0.032035663,"down","yes","AC120568.1","protein_coding","chr4:104566211-104574118:-","gi|672018429|ref|XP_008773992.1|",1655,0,"PREDICTED: SH2 domain-containing protein 6 [Rattus norvegicus]","gi|672018428|ref|XM_008775770.1|",709,0,"PREDICTED: Rattus norvegicus hypothetical protein LOC691161 (LOC691161), mRNA","Q9D413",423,{"v":2e-144,"d":"2.00E-144"},"SH2 domain-containing protein 6",".",".",".",".","pfam00017","SH2","SH2 domain.",".",".",".",".","."]
["ENSRNOG00000016353",3,0.249079982,12,0.771965258,0.322656983,-1.631926844,0.049159966,0.032035663,"down","yes","Nim1k","protein_coding","chr2:51670772-51714762:-","gi|62642955|ref|XP_227081.3|",2336,0,"PREDICTED: serine/threonine-protein kinase NIM1 [Rattus norvegicus]","gi|672041654|ref|XM_006231982.2|",2330,0,"PREDICTED: Rattus norvegicus NIM1 serine/threonine protein kinase (Nim1k), transcript variant X2, mRNA","Q8BHI9",869,0,"Serine/threonine-protein kinase NIM1",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006468|protein phosphorylation;GO:0035556|intracellular signal transduction;GO:0042149|cellular response to glucose starvation;",".","GO:0000287|magnesium ion binding;GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;","K16310","NIM1; serine/threonine-protein kinase NIM1 [EC:2.7.11.1]"]
["ENSRNOG00000031381",3,0.249079982,12,0.771965258,0.322656983,-1.631926844,0.049159966,0.032035663,"down","yes","AC129049.1","protein_coding","chr1:251920610-251921471:+","gi|602708647|ref|XP_007464583.1|",1257,{"v":2e-172,"d":"2.00E-172"},"PREDICTED: 60S ribosomal protein L8 [Lipotes vexillifer]","gi|672044822|ref|XM_002729143.4|",827,0,"PREDICTED: Rattus norvegicus ribosomal protein L8-like (LOC100360117), mRNA","P62919",487,{"v":2e-173,"d":"2.00E-173"},"60S ribosomal protein L8","YIL018w",368,{"v":3e-127,"d":"3.00E-127"},"COG0090","pfam03947","Ribosomal_L2_C","Ribosomal Proteins L2, C-terminal domain.",".",".",".",".","."]
["ENSRNOG00000062687",3,0.249079982,12,0.771965258,0.322656983,-1.631926844,0.049159966,0.032035663,"down","yes","ENSRNOG00000062687","lncRNA","chr3:2881223-2901974:-","gi|148694633|gb|EDL26580.1|",148,{"v":5e-10,"d":"5.00E-10"},"Cd99 antigen-like 2, isoform CRA_c [Mus musculus]","gi|672034225|ref|XR_349958.2|",174,{"v":2e-84,"d":"2.00E-84"},"PREDICTED: Rattus norvegicus uncharacterized LOC102552482 (LOC102552482), ncRNA","Q8BIF0",51.2,1e-07,"CD99 antigen-like protein 2",".",".",".",".","pfam15351","JCAD","Junctional protein associated with coronary artery disease. JCAD is a component of VE-cadherin-based cell-cell junctions in endothelial cells. The cell-cell or adherens junction is an adhesion complex that plays a crucial role in the organisation and function of epithelial and endothelial cellular sheets. These junctions join the actin cytoskeleton to the plasma membrane to form adhesive contacts between cells or between cells and extracellular matrix. The junctions also mediate both cell adhesion and cell-signalling. JCAD localizes close to the apical membrane in epithelial cells. This family is found in eukaryotes.",".",".",".",".","."]
["ENSRNOG00000065740",3,0.249079982,12,0.771965258,0.322656983,-1.631926844,0.049159966,0.032035663,"down","yes","Myh2","protein_coding","chr10:51856738-51883236:+","gi|205830436|ref|NP_001128629.1|",9186,0,"myosin heavy chain IIa [Rattus norvegicus]","gi|205830435|ref|NM_001135157.1|",6041,0,"Rattus norvegicus myosin, heavy chain 2, skeletal muscle, adult (Myh2), mRNA","Q076A7",3490,0,"Myosin-2","SPCC645.05c",749,0,"COG5022","pfam01576","Myosin_tail_1","Myosin tail. The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.",".",".",".",".","."]
["ENSRNOG00000066139",3,0.249079982,12,0.771965258,0.322656983,-1.631926844,0.049159966,0.032035663,"down","yes","ENSRNOG00000066139","pseudogene","chr7:12662391-12664176:-","gi|56090329|ref|NP_001007652.1|",763,{"v":1E-97,"d":"1.00E-97"},"peflin [Rattus norvegicus]","gi|56090328|ref|NM_001007651.1|",262,{"v":5e-133,"d":"5.00E-133"},"Rattus norvegicus penta-EF hand domain containing 1 (Pef1), mRNA","Q641Z8",298,{"v":3e-99,"d":"3.00E-99"},"Peflin",".",".",".",".","pfam13499","EF-hand_7","EF-hand domain pair.",".",".",".",".","."]
["ENSRNOG00000070802",3,0.249079982,12,0.771965258,0.322656983,-1.631926844,0.049159966,0.032035663,"down","yes","ENSRNOG00000070802","protein_coding","chr15:51432883-51433062:-","gi|90086087|dbj|BAE91596.1|",240,{"v":4e-25,"d":"4.00E-25"},"unnamed protein product [Macaca fascicularis]","gi|672069359|ref|XM_006247472.2|",159,{"v":2e-76,"d":"2.00E-76"},"PREDICTED: Rattus norvegicus ataxin 7-like 3 (Atxn7l3), transcript variant X6, mRNA",".",".",".",".",".",".",".",".","pfam07590","DUF1556","Protein of unknown function (DUF1556).",".",".",".",".","."]

{"sheet":"2D_CTX_up","index":3,"n_rows":1602,"n_cols":38,"rows_kept":1602}
["Gene","2D_count","2D_normalize","CTX_count","CTX_normalize","FoldChange","Log2FoldChange","pval","padj","Up/Down","Significant","GeneName","Biotype","Position","NR:Seq-id","NR:Score","NR:Evalue","NR:Description","NT:Seq-id","NT:Score","NT:Evalue","NT:Description","Uniprot:UniProtKB-AC","Uniprot:Score","Uniprot:Evalue","Uniprot:Description","COG:gene","COG:Score","COG:Eval","COG:num","Pfam:pfam_ID","Pfam:pfam_Name","Pfam:pfam_Description","GO:biological_process","GO:cellular_component","GO:molecular_function","KEGG:KO","KEGG:Description"]
["ENSRNOG00000030644",77735,6454.077456,30768,1979.318922,3.26075671,1.705206803,0,0,"up","yes","Mt-nd1","protein_coding","chrMT:2740-3694:+","gi|19577314|emb|CAD21559.1|",989,{"v":2e-130,"d":"2.00E-130"},"NADH dehydrogenase subunit 1, partial (mitochondrion) [Rattus norvegicus]","gi|755572967|gb|KP244683.1|",955,0,"Rattus norvegicus isolate 115 mitochondrion, complete genome","P03889",385,{"v":8e-132,"d":"8.00E-132"},"NADH-ubiquinone oxidoreductase chain 1","RC1230",187,{"v":5e-55,"d":"5.00E-55"},"COG1005","pfam00146","NADHdh","NADH dehydrogenase.","GO:0006120|mitochondrial electron transport, NADH to ubiquinone;GO:0009060|aerobic respiration;GO:0009410|response to xenobiotic stimulus;GO:0014070|response to organic cyclic compound;GO:0032981|mitochondrial respiratory chain complex I assembly;GO:0033194|response to hydroperoxide;","GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0005747|mitochondrial respiratory chain complex I;GO:0030425|dendrite;GO:0031966|mitochondrial membrane;GO:0043025|neuronal cell body;","GO:0003674|molecular_function;GO:0003954|NADH dehydrogenase activity;GO:0008137|NADH dehydrogenase (ubiquinone) activity;","K03878","ND1; NADH-ubiquinone oxidoreductase chain 1 [EC:7.1.1.2]"]
["ENSRNOG00000029707",78708,6534.862397,40826,2626.354469,2.488187513,1.315095213,0,0,"up","yes","Mt-nd4","protein_coding","chrMT:10160-11537:+","gi|829028|gb|AAD15023.1|",1149,{"v":3e-150,"d":"3.00E-150"},"unknown protein [Rattus norvegicus]","gi|755572967|gb|KP244683.1|",1378,0,"Rattus norvegicus isolate 115 mitochondrion, complete genome","P05508",446,{"v":2e-151,"d":"2.00E-151"},"NADH-ubiquinone oxidoreductase chain 4","BMEI1146",96.7,{"v":1e-20,"d":"1.00E-20"},"COG1008","pfam00361","Oxidored_q1","NADH-Ubiquinone/plastoquinone (complex I), various chains. This family is part of complex I which catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane.","GO:0001666|response to hypoxia;GO:0001701|in utero embryonic development;GO:0006120|mitochondrial electron transport, NADH to ubiquinone;GO:0007568|aging;GO:0009060|aerobic respiration;GO:0015990|electron transport coupled proton transport;GO:0021549|cerebellum development;GO:0032981|mitochondrial respiratory chain complex I assembly;GO:0035094|response to nicotine;GO:0045471|response to ethanol;","GO:0005575|cellular_component;GO:0005743|mitochondrial inner membrane;GO:0005747|mitochondrial respiratory chain complex I;GO:0045271|respiratory chain complex I;","GO:0003674|molecular_function;GO:0003954|NADH dehydrogenase activity;GO:0008137|NADH dehydrogenase (ubiquinone) activity;GO:0048039|ubiquinone binding;","K03881","ND4; NADH-ubiquinone oxidoreductase chain 4 [EC:7.1.1.2]"]
["ENSRNOG00000005825",19520,1620.680413,2629,169.124722,9.582752861,3.260440162,0,0,"up","yes","Lyz2","protein_coding","chr7:52906811-52912106:-","gi|674274809|tpe|CDM98787.1|",488,{"v":8E-55,"d":"8.00E-55"},"TPA: lysozyme f2 [Rattus norvegicus]","gi|349088|gb|L12459.1|RATLYSOZYM",891,0,"Rat lysozyme gene exons 1-4, complete cds","P00697",189,{"v":4E-55,"d":"4.00E-55"},"Lysozyme C-1",".",".",".",".","pfam00062","Lys","C-type lysozyme/alpha-lactalbumin family. Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.","GO:0001895|retina homeostasis;GO:0019835|cytolysis;GO:0031640|killing of cells of other organism;GO:0042742|defense response to bacterium;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;","GO:0000137|Golgi cis cisterna;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005788|endoplasmic reticulum lumen;GO:0005795|Golgi stack;GO:0005902|microvillus;GO:0030140|trans-Golgi network transport vesicle;GO:0030141|secretory granule;GO:0048237|rough endoplasmic reticulum lumen;","GO:0003796|lysozyme activity;GO:0016798|hydrolase activity, acting on glycosyl bonds;GO:0042802|identical protein binding;","K13915","LYZ; lysozyme C [EC:3.2.1.17]"]
["ENSRNOG00000033615",17946,1489.99645,3734,240.2098562,6.202894725,2.63294164,0,0,"up","yes","Mt-nd3","protein_coding","chrMT:9451-9798:+","gi|226453430|ref|YP_002791023.1|",227,{"v":1e-21,"d":"1.00E-21"},"NADH dehydrogenase subunit 3 [Rattus rattus]","gi|755572967|gb|KP244683.1|",348,0,"Rattus norvegicus isolate 115 mitochondrion, complete genome","P03899",91.3,{"v":7e-23,"d":"7.00E-23"},"NADH-ubiquinone oxidoreductase chain 3",".",".",".",".","pfam00507","Oxidored_q4","NADH-ubiquinone/plastoquinone oxidoreductase, chain 3.","GO:0006120|mitochondrial electron transport, NADH to ubiquinone;GO:0006979|response to oxidative stress;GO:0009642|response to light intensity;GO:0009725|response to hormone;GO:0071385|cellular response to glucocorticoid stimulus;","GO:0005575|cellular_component;GO:0005743|mitochondrial inner membrane;GO:0005747|mitochondrial respiratory chain complex I;GO:0030964|NADH dehydrogenase complex;","GO:0003674|molecular_function;GO:0008137|NADH dehydrogenase (ubiquinone) activity;","K03880","ND3; NADH-ubiquinone oxidoreductase chain 3 [EC:7.1.1.2]"]
["ENSRNOG00000018735",19269,1599.840722,4869,313.2249035,5.107642156,2.352657453,0,0,"up","yes","Cd74","protein_coding","chr18:54256778-54266003:+","gi|6978637|ref|NP_037201.1|",891,{"v":3e-111,"d":"3.00E-111"},"H-2 class II histocompatibility antigen gamma chain [Rattus norvegicus]","gi|672083268|ref|XM_006254761.2|",719,0,"PREDICTED: Rattus norvegicus Cd74 molecule, major histocompatibility complex, class II invariant chain (Cd74), transcript variant X1, mRNA","P10247",343,{"v":3e-110,"d":"3.00E-110"},"H-2 class II histocompatibility antigen gamma chain",".",".",".",".","pfam08831","MHCassoc_trimer","Class II MHC-associated invariant chain trimerization domain. The class II associated invariant chain peptide is required for folding and localisation of MHC class II heterodimers. This domain is involved in trimerization of the ectoderm and interferes with DM/class II binding. The trimeric protein forms a cylindrical shape which is thought to be important for interactions between the invariant chain and class II molecules.","GO:0001516|prostaglandin biosynthetic process;GO:0001934|positive regulation of protein phosphorylation;GO:0001961|positive regulation of cytokine-mediated signaling pathway;GO:0002286|T cell activation involved in immune response;GO:0002606|positive regulation of dendritic cell antigen processing and presentation;GO:0002792|negative regulation of peptide secretion;GO:0002830|positive regulation of type 2 immune response;GO:0002906|negative regulation of mature B cell apoptotic process;GO:0006886|intracellular protein transport;GO:0006952|defense response;GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0008283|cell proliferation;GO:0010628|positive regulation of gene expression;GO:0016064|immunoglobulin mediated immune response;GO:0019882|antigen processing and presentation;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0023019|signal transduction involved in regulation of gene expression;GO:0030336|negative regulation of cell migration;GO:0030890|positive regulation of B cell proliferation;GO:0031394|positive regulation of prostaglandin biosynthetic process;GO:0032722|positive regulation of chemokine production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0033674|positive regulation of kinase activity;GO:0034341|response to interferon-gamma;GO:0035691|macrophage migration inhibitory factor signaling pathway;GO:0043066|negative regulation of apoptotic process;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043410|positive regulation of MAPK cascade;GO:0043518|negative regulation of DNA damage response, signal transduction by p53 class mediator;GO:0045059|positive thymic T cell selection;GO:0045060|negative thymic T cell selection;GO:0045581|negative regulation of T cell differentiation;GO:0045582|positive regulation of T cell differentiation;GO:0045657|positive regulation of monocyte differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0046597|negative regulation of viral entry into host cell;GO:0046598|positive regulation of viral entry into host cell;GO:0048146|positive regulation of fibroblast proliferation;GO:0050729|positive regulation of inflammatory response;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050821|protein stabilization;GO:0051085|chaperone cofactor-dependent protein refolding;GO:0060907|positive regulation of macrophage cytokine production;GO:0065003|protein-containing complex assembly;GO:0070206|protein trimerization;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0090023|positive regulation of neutrophil chemotaxis;GO:1900017|positive regulation of cytokine production involved in inflammatory response;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1902166|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:2000343|positive regulation of chemokine (C-X-C motif) ligand 2 production;GO:2000448|positive regulation of macrophage migration inhibitory factor signaling pathway;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0005770|late endosome;GO:0005771|multivesicular body;GO:0005773|vacuole;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0032991|protein-containing complex;GO:0035692|macrophage migration inhibitory factor receptor complex;GO:0035693|NOS2-CD74 complex;GO:0042613|MHC class II protein complex;","GO:0001540|amyloid-beta binding;GO:0004896|cytokine receptor activity;GO:0019955|cytokine binding;GO:0023026|MHC class II protein complex binding;GO:0035718|macrophage migration inhibitory factor binding;GO:0042289|MHC class II protein binding;GO:0042609|CD4 receptor binding;GO:0042658|MHC class II protein binding, via antigen binding groove;GO:0044183|protein binding involved in protein folding;GO:0050998|nitric-oxide synthase binding;","K06505","CD74, DHLAG; CD74 antigen"]
["ENSRNOG00000017123",42840,3556.862137,23781,1529.84215,2.324986363,1.217222254,0,0,"up","yes","B2m","protein_coding","chr3:109095729-109101766:+","gi|7549746|ref|NP_036644.1|",537,{"v":5e-62,"d":"5.00E-62"},"beta-2-microglobulin precursor [Rattus norvegicus]","gi|332801023|ref|NM_012512.2|",1743,0,"Rattus norvegicus beta-2 microglobulin (B2m), mRNA","P07151",209,{"v":9e-63,"d":"9.00E-63"},"Beta-2-microglobulin",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.","GO:0001895|retina homeostasis;GO:0001916|positive regulation of T cell mediated cytotoxicity;GO:0002237|response to molecule of bacterial origin;GO:0002381|immunoglobulin production involved in immunoglobulin mediated immune response;GO:0002481|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent;GO:0002503|peptide antigen assembly with MHC class II protein complex;GO:0002726|positive regulation of T cell cytokine production;GO:0003254|regulation of membrane depolarization;GO:0006826|iron ion transport;GO:0006955|immune response;GO:0007611|learning or memory;GO:0009410|response to xenobiotic stimulus;GO:0010977|negative regulation of neuron projection development;GO:0019731|antibacterial humoral response;GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0032092|positive regulation of protein binding;GO:0033077|T cell differentiation in thymus;GO:0034756|regulation of iron ion transport;GO:0042026|protein refolding;GO:0045087|innate immune response;GO:0045646|regulation of erythrocyte differentiation;GO:0046686|response to cadmium ion;GO:0048260|positive regulation of receptor-mediated endocytosis;GO:0050680|negative regulation of epithelial cell proliferation;GO:0050768|negative regulation of neurogenesis;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:0050870|positive regulation of T cell activation;GO:0051289|protein homotetramerization;GO:0055072|iron ion homeostasis;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0071222|cellular response to lipopolysaccharide;GO:0071281|cellular response to iron ion;GO:0071283|cellular response to iron(III) ion;GO:0071316|cellular response to nicotine;GO:0090647|modulation of age-related behavioral decline;GO:1900121|negative regulation of receptor binding;GO:1900122|positive regulation of receptor binding;GO:1904434|positive regulation of ferrous iron binding;GO:1904437|positive regulation of transferrin receptor binding;GO:1990000|amyloid fibril formation;GO:2000774|positive regulation of cellular senescence;GO:2000978|negative regulation of forebrain neuron differentiation;","GO:0005615|extracellular space;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0042612|MHC class I protein complex;GO:0042613|MHC class II protein complex;GO:0042824|MHC class I peptide loading complex;GO:1990712|HFE-transferrin receptor complex;","GO:0003674|molecular_function;GO:0023026|MHC class II protein complex binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;","K08055","B2M; beta-2-microglobulin"]
["ENSRNOG00000017414",6892,572.2197443,229,14.73167034,38.84282848,5.279576354,0,0,"up","yes","Irf7","protein_coding","chr1:196367361-196370832:-","gi|76096318|ref|NP_001028863.1|",2147,0,"interferon regulatory factor 7 [Rattus norvegicus]","gi|564331708|ref|XM_006230540.1|",1989,0,"PREDICTED: Rattus norvegicus interferon regulatory factor 7 (Irf7), transcript variant X1, mRNA","P70434",696,0,"Interferon regulatory factor 7",".",".",".",".","pfam10401","IRF-3","Interferon-regulatory factor 3. This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1).  Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.","GO:0002376|immune system process;GO:0002819|regulation of adaptive immune response;GO:0006357|regulation of transcription by RNA polymerase II;GO:0010468|regulation of gene expression;GO:0016064|immunoglobulin mediated immune response;GO:0032481|positive regulation of type I interferon production;GO:0032727|positive regulation of interferon-alpha production;GO:0032728|positive regulation of interferon-beta production;GO:0034124|regulation of MyD88-dependent toll-like receptor signaling pathway;GO:0034127|regulation of MyD88-independent toll-like receptor signaling pathway;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051607|defense response to virus;GO:0060337|type I interferon signaling pathway;GO:0060340|positive regulation of type I interferon-mediated signaling pathway;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987|proximal promoter sequence-specific DNA binding;GO:0003677|DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09447","IRF7; interferon regulatory factor 7"]
["ENSRNOG00000062337",5877,487.9476839,264,16.98323568,28.73113776,4.84454322,0,0,"up","yes","ENSRNOG00000062337","rRNA","chr3:2231807-2233678:+","gi|296473176|tpg|DAA15291.1|",778,{"v":2e-96,"d":"2.00E-96"},"TPA: hypothetical protein BOS_23236 [Bos taurus]","gi|380750581|gb|JQ247698.1|",1859,0,"Mus musculus cell-line Neuro-2a 18S ribosomal RNA, complete sequence","Q5DU56",68.6,{"v":1E-10,"d":"1.00E-10"},"Protein NLRC3",".",".",".",".","pfam11847","DUF3367","Domain of unknown function (DUF3367). This domain is functionally uncharacterized. This domain is found in bacteria and archaea. This presumed domain is typically between 667 to 694 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000007091",9086,754.3802375,2514,161.7267216,4.664536757,2.221733812,0,0,"up","yes","Ly6e","protein_coding","chr7:106935761-106939689:+","gi|564360434|ref|XP_006241819.1|",696,{"v":2e-84,"d":"2.00E-84"},"PREDICTED: lymphocyte antigen 6E isoform X2 [Rattus norvegicus]","gi|672059464|ref|XM_006241757.2|",1766,0,"PREDICTED: Rattus norvegicus lymphocyte antigen 6 complex, locus E (Ly6e), transcript variant X1, mRNA","Q64253",201,{"v":2e-59,"d":"2.00E-59"},"Lymphocyte antigen 6E",".",".",".",".","pfam00021","UPAR_LY6","u-PAR/Ly-6 domain. This extracellular disulphide bond rich domain is related to pfam00087.","GO:0001701|in utero embryonic development;GO:0030325|adrenal gland development;GO:0035265|organ growth;GO:0042415|norepinephrine metabolic process;GO:0046597|negative regulation of viral entry into host cell;GO:0048242|epinephrine secretion;GO:0055010|ventricular cardiac muscle tissue morphogenesis;GO:0095500|acetylcholine receptor signaling pathway;GO:2000272|negative regulation of signaling receptor activity;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0031225|anchored component of membrane;GO:0045202|synapse;","GO:0030550|acetylcholine receptor inhibitor activity;GO:0033130|acetylcholine receptor binding;","K06846","LY6D_E_F_G6_H; lymphocyte antigen 6 complex locus protein D/E/F/G6/H"]
["ENSRNOG00000029971",20044,1664.186384,10767,692.6458279,2.402651278,1.26462727,0,0,"up","yes","Mt-nd5","protein_coding","chrMT:11736-13565:+","gi|110189725|ref|YP_665639.1|",2147,0,"NADH dehydrogenase subunit 5 [Rattus norvegicus]","gi|755572967|gb|KP244683.1|",1830,0,"Rattus norvegicus isolate 115 mitochondrion, complete genome","P11661",831,0,"NADH-ubiquinone oxidoreductase chain 5","AGc2360",257,{"v":4e-75,"d":"4.00E-75"},"COG1009","pfam00361","Oxidored_q1","NADH-Ubiquinone/plastoquinone (complex I), various chains. This family is part of complex I which catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane.","GO:0001666|response to hypoxia;GO:0006120|mitochondrial electron transport, NADH to ubiquinone;GO:0010243|response to organonitrogen compound;GO:0015990|electron transport coupled proton transport;GO:0032981|mitochondrial respiratory chain complex I assembly;GO:0042542|response to hydrogen peroxide;","GO:0005743|mitochondrial inner membrane;GO:0005747|mitochondrial respiratory chain complex I;GO:0043005|neuron projection;","GO:0003674|molecular_function;GO:0003954|NADH dehydrogenase activity;GO:0008137|NADH dehydrogenase (ubiquinone) activity;","K03883","ND5; NADH-ubiquinone oxidoreductase chain 5 [EC:7.1.1.2]"]
["ENSRNOG00000061813",4535,376.5259055,82,5.275095931,71.37802049,6.157407987,0,0,"up","yes","Ly6c","protein_coding","chr7:106959511-106963329:-","gi|9910398|ref|NP_064488.1|",500,{"v":1e-57,"d":"1.00E-57"},"Ly6-C antigen precursor [Rattus norvegicus]","gi|672075999|ref|XM_003751343.2|",727,0,"PREDICTED: Rattus norvegicus lymphocyte antigen 6B-like (LOC100911104), mRNA","Q63317",129,{"v":4e-34,"d":"4.00E-34"},"Lymphocyte antigen 6B",".",".",".",".","pfam00021","UPAR_LY6","u-PAR/Ly-6 domain. This extracellular disulphide bond rich domain is related to pfam00087.","GO:0095500|acetylcholine receptor signaling pathway;GO:2000272|negative regulation of signaling receptor activity;","GO:0005886|plasma membrane;GO:0045202|synapse;","GO:0030550|acetylcholine receptor inhibitor activity;GO:0033130|acetylcholine receptor binding;","K06846","LY6D_E_F_G6_H; lymphocyte antigen 6 complex locus protein D/E/F/G6/H"]
["ENSRNOG00000009263",9683,803.9471539,3220,207.144011,3.881102573,1.956466562,0,0,"up","yes","Ifi27","protein_coding","chr6:122590472-122779294:+","gi|149025408|gb|EDL81775.1|",493,{"v":3e-58,"d":"3.00E-58"},"rCG20848, isoform CRA_b [Rattus norvegicus]","gi|298888013|emb|FQ233730.1|",827,0,"Rattus norvegicus TL0AEA60YK12 mRNA sequence","Q8R412",78.2,{"v":5e-17,"d":"5.00E-17"},"Interferon alpha-inducible protein 27-like protein 2A",".",".",".",".","pfam06140","Ifi-6-16","Interferon-induced 6-16 family.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006915|apoptotic process;GO:0032355|response to estradiol;GO:0034097|response to cytokine;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0044827|modulation by host of viral genome replication;GO:0045087|innate immune response;GO:0046825|regulation of protein export from nucleus;GO:0051607|defense response to virus;GO:0060135|maternal process involved in female pregnancy;GO:0060337|type I interferon signaling pathway;GO:0070936|protein K48-linked ubiquitination;GO:0097190|apoptotic signaling pathway;GO:0097191|extrinsic apoptotic signaling pathway;","GO:0005575|cellular_component;GO:0005635|nuclear envelope;GO:0005637|nuclear inner membrane;GO:0005739|mitochondrion;GO:0016021|integral component of membrane;GO:0031966|mitochondrial membrane;","GO:0003674|molecular_function;GO:0005521|lamin binding;GO:0042802|identical protein binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;",".","."]
["ENSRNOG00000001959",4056,336.7561351,42,2.701878404,124.6377833,6.96159767,0,0,"up","yes","Mx1","protein_coding","chr11:36799660-36823507:-","gi|71534287|ref|NP_775119.2|",3312,0,"interferon-induced GTP-binding protein Mx1 [Rattus norvegicus]","gi|402692028|ref|NM_173096.3|",3320,0,"Rattus norvegicus myxovirus (influenza virus) resistance 1 (Mx1), transcript variant 1, mRNA","P18588",1270,0,"Interferon-induced GTP-binding protein Mx1","YLL001w",225,{"v":8e-61,"d":"8.00E-61"},"COG0699","pfam01031","Dynamin_M","Dynamin central region. This region lies between the GTPase domain, see pfam00350, and the pleckstrin homology (PH) domain, see pfam00169.","GO:0009615|response to virus;GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0051607|defense response to virus;GO:0070106|interleukin-27-mediated signaling pathway;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005789|endoplasmic reticulum membrane;GO:0005829|cytosol;GO:0005874|microtubule;GO:0016020|membrane;GO:0031965|nuclear membrane;GO:0048471|perinuclear region of cytoplasm;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0008017|microtubule binding;GO:0042802|identical protein binding;","K14754","MX; interferon-induced GTP-binding protein Mx"]
["ENSRNOG00000026605",4963,412.0613162,892,57.38275086,7.180926498,2.844169996,0,0,"up","yes","Ifi27l2b","protein_coding","chr6:122598872-122600360:-","gi|12845165|dbj|BAB26643.1|",159,{"v":2e-11,"d":"2.00E-11"},"unnamed protein product [Mus musculus]","gi|402747131|ref|NM_206846.2|",451,0,"Rattus norvegicus interferon, alpha-inducible protein 27 like 2B (Ifi27l2b), mRNA",".",".",".",".",".",".",".",".","pfam06140","Ifi-6-16","Interferon-induced 6-16 family.","GO:0006915|apoptotic process;GO:0007568|aging;GO:0009615|response to virus;GO:0097190|apoptotic signaling pathway;","GO:0005739|mitochondrion;GO:0016021|integral component of membrane;GO:0031966|mitochondrial membrane;",".",".","."]
["ENSRNOG00000032844",6259,519.6638682,1731,111.3559885,4.666689913,2.222399608,0,0,"up","yes","RT1-Da","protein_coding","chr20:4512911-4518455:+","gi|40556829|gb|AAR87772.1|",1061,{"v":6e-131,"d":"6.00E-131"},"MHC class II antigen alpha chain [Rattus norvegicus]","gi|46237557|emb|BX883043.1|",3116,0,"Rattus norvegicus chromosome 20, major histocompatibility complex, assembled from 40 BACs, strain Brown Norway (BN/ssNHsd), RT1n haplotype; segment 2/11","P14439",384,{"v":2E-121,"d":"2.00E-121"},"H-2 class II histocompatibility antigen, E-U alpha chain",".",".",".",".","pfam00993","MHC_II_alpha","Class II histocompatibility antigen, alpha domain.","GO:0001916|positive regulation of T cell mediated cytotoxicity;GO:0002250|adaptive immune response;GO:0002381|immunoglobulin production involved in immunoglobulin mediated immune response;GO:0002469|myeloid dendritic cell antigen processing and presentation;GO:0002491|antigen processing and presentation of endogenous peptide antigen via MHC class II;GO:0002503|peptide antigen assembly with MHC class II protein complex;GO:0002504|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;GO:0008150|biological_process;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0032831|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0043382|positive regulation of memory T cell differentiation;GO:0045622|regulation of T-helper cell differentiation;GO:0050870|positive regulation of T cell activation;GO:0050890|cognition;GO:2000516|positive regulation of CD4-positive, alpha-beta T cell activation;","GO:0001772|immunological synapse;GO:0005575|cellular_component;GO:0005764|lysosome;GO:0005765|lysosomal membrane;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0031902|late endosome membrane;GO:0042613|MHC class II protein complex;","GO:0003674|molecular_function;GO:0023026|MHC class II protein complex binding;GO:0030247|polysaccharide binding;GO:0042605|peptide antigen binding;GO:0042608|T cell receptor binding;","K06752","MHC2; MHC class II antigen"]
["ENSRNOG00000000451",3098,257.2165943,143,9.19925266,27.96059678,4.805323248,0,0,"up","yes","RT1-Ba","protein_coding","chr20:4575134-4579744:+","gi|57012346|ref|NP_001008831.1|",1105,{"v":1E-146,"d":"1.00E-146"},"rano class II histocompatibility antigen, B alpha chain precursor [Rattus norvegicus]","gi|89214481|gb|AC120734.5|",705,0,"Rattus norvegicus BAC CH230-220D1 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P20037",380,{"v":8e-129,"d":"8.00E-129"},"Rano class II histocompatibility antigen, B alpha chain",".",".",".",".","pfam00993","MHC_II_alpha","Class II histocompatibility antigen, alpha domain.","GO:0002250|adaptive immune response;GO:0002381|immunoglobulin production involved in immunoglobulin mediated immune response;GO:0002503|peptide antigen assembly with MHC class II protein complex;GO:0019882|antigen processing and presentation;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0034341|response to interferon-gamma;GO:0042130|negative regulation of T cell proliferation;GO:0045582|positive regulation of T cell differentiation;GO:0048002|antigen processing and presentation of peptide antigen;GO:0050870|positive regulation of T cell activation;GO:0071385|cellular response to glucocorticoid stimulus;","GO:0005575|cellular_component;GO:0005764|lysosome;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0042613|MHC class II protein complex;","GO:0023026|MHC class II protein complex binding;GO:0042605|peptide antigen binding;GO:0044877|protein-containing complex binding;","K06752","MHC2; MHC class II antigen"]
["ENSRNOG00000003897",16736,1389.534191,10315,663.5684699,2.094032875,1.066284092,0,0,"up","yes","Col1a1","protein_coding","chr10:79883622-79900624:+","gi|455975|gb|AAB29425.1|",1373,{"v":8e-171,"d":"8.00E-171"},"type I collagen alpha 1 chain [Mus sp.]","gi|158711703|ref|NM_053304.1|",5825,0,"Rattus norvegicus collagen, type I, alpha 1 (Col1a1), mRNA","P02454",555,{"v":2e-166,"d":"2.00E-166"},"Collagen alpha-1(I) chain",".",".",".",".","pfam01410","COLFI","Fibrillar collagen C-terminal domain. Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1 alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.","GO:0001501|skeletal system development;GO:0001503|ossification;GO:0001568|blood vessel development;GO:0001649|osteoblast differentiation;GO:0001957|intramembranous ossification;GO:0001958|endochondral ossification;GO:0007584|response to nutrient;GO:0007601|visual perception;GO:0007605|sensory perception of sound;GO:0009410|response to xenobiotic stimulus;GO:0009612|response to mechanical stimulus;GO:0010718|positive regulation of epithelial to mesenchymal transition;GO:0010812|negative regulation of cell-substrate adhesion;GO:0015031|protein transport;GO:0030198|extracellular matrix organization;GO:0030199|collagen fibril organization;GO:0030335|positive regulation of cell migration;GO:0031667|response to nutrient levels;GO:0031960|response to corticosteroid;GO:0032355|response to estradiol;GO:0032964|collagen biosynthetic process;GO:0034504|protein localization to nucleus;GO:0034505|tooth mineralization;GO:0038063|collagen-activated tyrosine kinase receptor signaling pathway;GO:0042060|wound healing;GO:0042542|response to hydrogen peroxide;GO:0043434|response to peptide hormone;GO:0043588|skin development;GO:0043589|skin morphogenesis;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0044691|tooth eruption;GO:0045893|positive regulation of transcription, DNA-templated;GO:0048545|response to steroid hormone;GO:0048705|skeletal system morphogenesis;GO:0048706|embryonic skeletal system development;GO:0051591|response to cAMP;GO:0055093|response to hyperoxia;GO:0060325|face morphogenesis;GO:0060346|bone trabecula formation;GO:0060351|cartilage development involved in endochondral bone morphogenesis;GO:0071230|cellular response to amino acid stimulus;GO:0071260|cellular response to mechanical stimulus;GO:0071300|cellular response to retinoic acid;GO:0071306|cellular response to vitamin E;GO:0071356|cellular response to tumor necrosis factor;GO:0071364|cellular response to epidermal growth factor stimulus;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:1902617|response to fluoride;GO:1902618|cellular response to fluoride;","GO:0005576|extracellular region;GO:0005581|collagen trimer;GO:0005584|collagen type I trimer;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0030141|secretory granule;GO:0031012|extracellular matrix;","GO:0002020|protease binding;GO:0005201|extracellular matrix structural constituent;GO:0005515|protein binding;GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0048407|platelet-derived growth factor binding;","K06236","COL1A; collagen type I alpha"]
["ENSRNOG00000033215",3507,291.1744985,427,27.4690971,10.60007533,3.406002612,0,0,"up","yes","RT1-Db1","protein_coding","chr20:4548666-4558258:-","gi|57114286|ref|NP_001008884.1|",1137,{"v":2e-139,"d":"2.00E-139"},"rano class II histocompatibility antigen, D-1 beta chain precursor [Rattus norvegicus]","gi|89214481|gb|AC120734.5|",4227,0,"Rattus norvegicus BAC CH230-220D1 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P18211",399,{"v":9e-126,"d":"9.00E-126"},"Rano class II histocompatibility antigen, D-1 beta chain",".",".",".",".","pfam00969","MHC_II_beta","Class II histocompatibility antigen, beta domain.","GO:0001916|positive regulation of T cell mediated cytotoxicity;GO:0001934|positive regulation of protein phosphorylation;GO:0002250|adaptive immune response;GO:0002381|immunoglobulin production involved in immunoglobulin mediated immune response;GO:0002437|inflammatory response to antigenic stimulus;GO:0002469|myeloid dendritic cell antigen processing and presentation;GO:0002491|antigen processing and presentation of endogenous peptide antigen via MHC class II;GO:0002503|peptide antigen assembly with MHC class II protein complex;GO:0002504|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;GO:0002842|positive regulation of T cell mediated immune response to tumor cell;GO:0002862|negative regulation of inflammatory response to antigenic stimulus;GO:0006955|immune response;GO:0006959|humoral immune response;GO:0007165|signal transduction;GO:0010033|response to organic substance;GO:0016045|detection of bacterium;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030225|macrophage differentiation;GO:0032653|regulation of interleukin-10 production;GO:0032673|regulation of interleukin-4 production;GO:0032689|negative regulation of interferon-gamma production;GO:0032831|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0033674|positive regulation of kinase activity;GO:0034341|response to interferon-gamma;GO:0035774|positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0042088|T-helper 1 type immune response;GO:0042130|negative regulation of T cell proliferation;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043382|positive regulation of memory T cell differentiation;GO:0043410|positive regulation of MAPK cascade;GO:0045622|regulation of T-helper cell differentiation;GO:0045657|positive regulation of monocyte differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0046598|positive regulation of viral entry into host cell;GO:0050852|T cell receptor signaling pathway;GO:0050870|positive regulation of T cell activation;GO:0051262|protein tetramerization;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071548|response to dexamethasone;GO:2000516|positive regulation of CD4-positive, alpha-beta T cell activation;","GO:0001772|immunological synapse;GO:0005575|cellular_component;GO:0005765|lysosomal membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0031902|late endosome membrane;GO:0042613|MHC class II protein complex;","GO:0003674|molecular_function;GO:0023026|MHC class II protein complex binding;GO:0030247|polysaccharide binding;GO:0032395|MHC class II receptor activity;GO:0042605|peptide antigen binding;GO:0042608|T cell receptor binding;GO:0042609|CD4 receptor binding;","K06752","MHC2; MHC class II antigen"]
["ENSRNOG00000032825",4134,343.2322146,758,48.76247214,7.038859999,2.815341791,0,0,"up","yes","Rpl30","protein_coding","chr10:36831500-36831990:-","gi|664777237|ref|XP_008507911.1|",610,{"v":5e-78,"d":"5.00E-78"},"PREDICTED: 60S ribosomal protein L30-like [Equus przewalskii]","gi|672024756|ref|XM_003752328.3|",487,0,"PREDICTED: Rattus norvegicus ribosomal protein L30-like (LOC100362027), mRNA","P62890",236,{"v":1E-78,"d":"1.00E-78"},"60S ribosomal protein L30","SPAC9G1.03c",153,{"v":5e-47,"d":"5.00E-47"},"COG1911","pfam01248","Ribosomal_L7Ae","Ribosomal protein L7Ae/L30e/S12e/Gadd45 family. This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118.",".","GO:0005829|cytosol;",".","K02908","RP-L30e, RPL30; large subunit ribosomal protein L30e"]
["ENSRNOG00000029042",5139,426.6740084,1441,92.70016142,4.602732098,2.202490473,0,0,"up","yes","Mt-nd6","protein_coding","chrMT:13543-14061:-","gi|110189726|ref|YP_665640.1|",727,{"v":3e-95,"d":"3.00E-95"},"NADH dehydrogenase subunit 6 [Rattus norvegicus]","gi|755572967|gb|KP244683.1|",519,0,"Rattus norvegicus isolate 115 mitochondrion, complete genome","P03926",284,{"v":1e-96,"d":"1.00E-96"},"NADH-ubiquinone oxidoreductase chain 6",".",".",".",".","pfam00499","Oxidored_q3","NADH-ubiquinone/plastoquinone oxidoreductase chain 6.","GO:0006120|mitochondrial electron transport, NADH to ubiquinone;GO:0032981|mitochondrial respiratory chain complex I assembly;GO:0035094|response to nicotine;GO:0042220|response to cocaine;GO:0042542|response to hydrogen peroxide;","GO:0005575|cellular_component;GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0016021|integral component of membrane;GO:0070469|respiratory chain;","GO:0003674|molecular_function;GO:0008137|NADH dehydrogenase (ubiquinone) activity;","K03884","ND6; NADH-ubiquinone oxidoreductase chain 6 [EC:7.1.1.2]"]
["ENSRNOG00000065254",2788,231.4783295,194,12.48010501,18.54778701,4.21317516,0,0,"up","yes","RT1-CE16","protein_coding","chr20:3257123-3279563:-","gi|57012412|ref|NP_001008838.1|",1715,0,"RT1 class I, locus CE15 precursor [Rattus norvegicus]","gi|1794200|gb|U50449.1|RNU50449",1544,0,"Rattus norvegicus clone 109 class I MHC heavy chain RT1.A(n) antigen precursor (RT1.A(n)) mRNA, complete cds","P16391",544,{"v":9E-175,"d":"9.00E-175"},"RT1 class I histocompatibility antigen, AA alpha chain",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.",".",".",".",".","."]
["ENSRNOG00000051235",4553,378.0203854,1148,73.85134304,5.118666362,2.355767974,0,0,"up","yes","Cfb","protein_coding","chr20:3951474-3976505:+","gi|47575877|ref|NP_757376.2|",3941,0,"complement C2 precursor [Rattus norvegicus]","gi|47575876|ref|NM_172222.2|",1879,0,"Rattus norvegicus complement component 2 (C2), mRNA","P21180",1314,0,"Complement C2",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0006508|proteolysis;GO:0006956|complement activation;GO:0006958|complement activation, classical pathway;GO:0007584|response to nutrient;GO:0045087|innate immune response;GO:2000427|positive regulation of apoptotic cell clearance;","GO:0005575|cellular_component;GO:0005576|extracellular region;","GO:0004252|serine-type endopeptidase activity;GO:0005515|protein binding;","K01332","C2; complement component 2 [EC:3.4.21.43]"]
["ENSRNOG00000063244",3323,275.8975929,497,31.97222778,8.629288983,3.109241692,0,0,"up","yes","Mpeg1","protein_coding","chr1:209452133-209458855:+","gi|768711622|ref|NP_072139.2|",3691,0,"macrophage-expressed gene 1 protein precursor [Rattus norvegicus]","gi|672039844|ref|XM_008760261.1|",4306,0,"PREDICTED: Rattus norvegicus macrophage expressed 1 (Mpeg1), transcript variant X2, mRNA","Q9WV57",1402,0,"Macrophage-expressed gene 1 protein",".",".",".",".","pfam01823","MACPF","MAC/Perforin domain. The membrane-attack complex (MAC) of the complement system forms transmembrane channels. These channels disrupt the phospholipid bilayer of target cells, leading to cell lysis and death. A number of proteins participate in the assembly of the MAC. Freshly activated C5b binds to C6 to form a C5b-6 complex, then to C7 forming the C5b-7 complex. The C5b-7 complex binds to C8, which is composed of three chains (alpha, beta, and gamma), thus forming the C5b-8 complex. C5b-8 subsequently binds to C9 and acts as a catalyst in the polymerization of C9. Active MAC has a subunit composition of C5b-C6-C7-C8-C9{n}. Perforin is a protein found in cytolytic T-cell and killer cells. In the presence of calcium, perforin polymerizes into transmembrane tubules and is capable of lysing, non-specifically, a variety of target cells. There are a number of regions of similarity in the sequences of complement components C6, C7, C8-alpha, C8-beta, C9 and perforin. The X-ray crystal structure of a MACPF domain reveals that it shares a common fold with bacterial cholesterol dependent cytolysins (pfam01289) such as perfringolysin O. Three key pieces of evidence suggests that MACPF domains and CDCs are homologous: Functional similarity (pore formation), conservation of three glycine residues at a hinge in both families and conservation of a complex core fold.",".",".",".",".","."]
["ENSRNOG00000020035",2282,189.4668393,134,8.620278717,21.97920108,4.458067042,0,0,"up","yes","Cyp17a1","protein_coding","chr1:245535462-245541573:-","gi|564333876|ref|XP_006231496.1|",2594,0,"PREDICTED: steroid 17-alpha-hydroxylase/17,20 lyase isoform X1 [Rattus norvegicus]","gi|672040337|ref|XM_006231435.2|",1830,0,"PREDICTED: Rattus norvegicus cytochrome P450, family 17, subfamily a, polypeptide 1 (Cyp17a1), transcript variant X2, mRNA","P11715",983,0,"Steroid 17-alpha-hydroxylase/17,20 lyase","BH0579",116,{"v":6e-27,"d":"6.00E-27"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0006082|organic acid metabolic process;GO:0006694|steroid biosynthetic process;GO:0006702|androgen biosynthetic process;GO:0006704|glucocorticoid biosynthetic process;GO:0008202|steroid metabolic process;GO:0008584|male gonad development;GO:0009410|response to xenobiotic stimulus;GO:0009635|response to herbicide;GO:0009636|response to toxic substance;GO:0010033|response to organic substance;GO:0010034|response to acetate;GO:0010212|response to ionizing radiation;GO:0014070|response to organic cyclic compound;GO:0017085|response to insecticide;GO:0018879|biphenyl metabolic process;GO:0018894|dibenzo-p-dioxin metabolic process;GO:0018958|phenol-containing compound metabolic process;GO:0018963|phthalate metabolic process;GO:0021766|hippocampus development;GO:0030325|adrenal gland development;GO:0030728|ovulation;GO:0031667|response to nutrient levels;GO:0032526|response to retinoic acid;GO:0033327|Leydig cell differentiation;GO:0034097|response to cytokine;GO:0034698|response to gonadotropin;GO:0042446|hormone biosynthetic process;GO:0042448|progesterone metabolic process;GO:0048545|response to steroid hormone;GO:0051591|response to cAMP;GO:0051597|response to methylmercury;GO:0060992|response to fungicide;GO:0071222|cellular response to lipopolysaccharide;GO:0071236|cellular response to antibiotic;GO:0071371|cellular response to gonadotropin stimulus;GO:0090031|positive regulation of steroid hormone biosynthetic process;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016020|membrane;GO:0030424|axon;GO:0042995|cell projection;GO:0043025|neuronal cell body;GO:0043231|intracellular membrane-bounded organelle;","GO:0004508|steroid 17-alpha-monooxygenase activity;GO:0005506|iron ion binding;GO:0020037|heme binding;GO:0047442|17-alpha-hydroxyprogesterone aldolase activity;","K00512","CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase [EC:1.14.14.19 1.14.14.32]"]
["ENSRNOG00000001136",9946,825.7831656,5566,358.0632189,2.306249628,1.205548679,0,0,"up","yes","Pebp1","protein_coding","chr12:39302840-39307862:+","gi|149063507|gb|EDM13830.1|",984,{"v":2e-126,"d":"2.00E-126"},"phosphatidylethanolamine binding protein 1, isoform CRA_b, partial [Rattus norvegicus]","gi|298900721|emb|FQ212424.1|",738,0,"Rattus norvegicus TL0AAA55YH19 mRNA sequence","P31044",227,{"v":3E-68,"d":"3.00E-68"},"Phosphatidylethanolamine-binding protein 1",".",".",".",".","pfam01161","PBP","Phosphatidylethanolamine-binding protein.","GO:0000165|MAPK cascade;GO:0001505|regulation of neurotransmitter levels;GO:0001933|negative regulation of protein phosphorylation;GO:0002026|regulation of the force of heart contraction;GO:0006979|response to oxidative stress;GO:0007286|spermatid development;GO:0007568|aging;GO:0009408|response to heat;GO:0009410|response to xenobiotic stimulus;GO:0009611|response to wounding;GO:0009636|response to toxic substance;GO:0010033|response to organic substance;GO:0010243|response to organonitrogen compound;GO:0010951|negative regulation of endopeptidase activity;GO:0014070|response to organic cyclic compound;GO:0014823|response to activity;GO:0021766|hippocampus development;GO:0042755|eating behavior;GO:0043409|negative regulation of MAPK cascade;GO:0043950|positive regulation of cAMP-mediated signaling;GO:0045471|response to ethanol;GO:0045840|positive regulation of mitotic nuclear division;GO:0048240|sperm capacitation;GO:0051412|response to corticosterone;GO:0051591|response to cAMP;GO:0051592|response to calcium ion;GO:0051602|response to electrical stimulus;GO:0060409|positive regulation of acetylcholine metabolic process;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0005791|rough endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0008021|synaptic vesicle;GO:0009986|cell surface;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043679|axon terminus;GO:0045177|apical part of cell;","GO:0004867|serine-type endopeptidase inhibitor activity;GO:0005102|signaling receptor binding;GO:0005524|ATP binding;GO:0008289|lipid binding;GO:0019899|enzyme binding;GO:0019900|kinase binding;GO:0019901|protein kinase binding;GO:0033612|receptor serine/threonine kinase binding;GO:0051019|mitogen-activated protein kinase binding;","K06910","PEBP, TFS1; phosphatidylethanolamine-binding protein"]
["ENSRNOG00000008816",4410,366.1475729,1386,89.16198732,4.106543426,2.037924554,0,0,"up","yes","Gpnmb","protein_coding","chr4:78010197-78049367:+","gi|62286672|sp|Q6P7C7.1|GPNMB_RAT",2738,0,"RecName: Full=Transmembrane glycoprotein NMB; Flags: Precursor","gi|18959233|ref|NM_133298.1|",1866,0,"Rattus norvegicus glycoprotein nmb (Gpnmb), mRNA","Q6P7C7",1059,0,"Transmembrane glycoprotein NMB",".",".",".",".","pfam00801","PKD","PKD domain. This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.","GO:0001649|osteoblast differentiation;GO:0001818|negative regulation of cytokine production;GO:0001934|positive regulation of protein phosphorylation;GO:0007155|cell adhesion;GO:0007165|signal transduction;GO:0007267|cell-cell signaling;GO:0030282|bone mineralization;GO:0030335|positive regulation of cell migration;GO:0031954|positive regulation of protein autophosphorylation;GO:0032720|negative regulation of tumor necrosis factor production;GO:0034103|regulation of tissue remodeling;GO:0042130|negative regulation of T cell proliferation;GO:0050868|negative regulation of T cell activation;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:1901215|negative regulation of neuron death;GO:2000134|negative regulation of G1/S transition of mitotic cell cycle;","GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;GO:0031410|cytoplasmic vesicle;GO:0031901|early endosome membrane;GO:0033162|melanosome membrane;","GO:0005178|integrin binding;GO:0008201|heparin binding;GO:0045545|syndecan binding;GO:0048018|receptor ligand activity;","K20732","GPNMB; transmembrane glycoprotein NMB"]
["ENSRNOG00000003217",5543,460.2167793,2192,141.0123205,3.263663612,1.706492366,0,0,"up","yes","Lgals3bp","protein_coding","chr10:103619908-103629256:-","gi|149054938|gb|EDM06755.1|",2999,0,"lectin, galactoside-binding, soluble, 3 binding protein, isoform CRA_a [Rattus norvegicus]","gi|20806134|ref|NM_139096.1|",2090,0,"Rattus norvegicus lectin, galactoside-binding, soluble, 3 binding protein (Lgals3bp), mRNA","O70513",1158,0,"Galectin-3-binding protein",".",".",".",".","pfam00530","SRCR","Scavenger receptor cysteine-rich domain. These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.","GO:0006897|endocytosis;GO:0007155|cell adhesion;","GO:0005615|extracellular space;GO:0016020|membrane;","GO:0005044|scavenger receptor activity;","K17300","LGALS3BP; galectin-3-binding protein"]
["ENSRNOG00000000777",2486,206.4042781,381,24.50989695,8.421262582,3.07403655,0,0,"up","yes","RT1-S3","protein_coding","chr20:2670709-2675411:+","gi|261878529|ref|NP_001008886.2|",1806,0,"RT1 class Ib, locus S3 precursor [Rattus norvegicus]","gi|261878528|ref|NM_001008886.2|",2682,0,"Rattus norvegicus RT1 class Ib, locus S3 (RT1-S3), mRNA","P06339",544,0,"H-2 class I histocompatibility antigen, D-37 alpha chain",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.","GO:0001815|positive regulation of antibody-dependent cellular cytotoxicity;GO:0001916|positive regulation of T cell mediated cytotoxicity;GO:0002250|adaptive immune response;GO:0002476|antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002477|antigen processing and presentation of exogenous peptide antigen via MHC class Ib;GO:0002486|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0002489|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent;GO:0002519|natural killer cell tolerance induction;GO:0002639|positive regulation of immunoglobulin production;GO:0002715|regulation of natural killer cell mediated immunity;GO:0002717|positive regulation of natural killer cell mediated immunity;GO:0002729|positive regulation of natural killer cell cytokine production;GO:0006955|immune response;GO:0019731|antibacterial humoral response;GO:0032736|positive regulation of interleukin-13 production;GO:0032753|positive regulation of interleukin-4 production;GO:0032759|positive regulation of TRAIL production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032819|positive regulation of natural killer cell proliferation;GO:0036037|CD8-positive, alpha-beta T cell activation;GO:0042270|protection from natural killer cell mediated cytotoxicity;GO:0045953|negative regulation of natural killer cell mediated cytotoxicity;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;GO:0048839|inner ear development;GO:0050830|defense response to Gram-positive bacterium;GO:2000566|positive regulation of CD8-positive, alpha-beta T cell proliferation;GO:2001187|positive regulation of CD8-positive, alpha-beta T cell activation;","GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0032398|MHC class Ib protein complex;GO:0042612|MHC class I protein complex;","GO:0005102|signaling receptor binding;GO:0030881|beta-2-microglobulin binding;GO:0042288|MHC class I protein binding;GO:0042605|peptide antigen binding;GO:0042608|T cell receptor binding;GO:0046703|natural killer cell lectin-like receptor binding;","K06751","MHC1; MHC class I antigen"]
["ENSRNOG00000031743",2924,242.7699554,741,47.66885469,5.092842212,2.34847102,0,0,"up","yes","Gbp2","protein_coding","chr2:231332284-231348571:+","gi|19424350|ref|NP_598308.1|",3150,0,"guanylate-binding protein 1 [Rattus norvegicus]","gi|402691659|ref|NM_133624.2|",2390,0,"Rattus norvegicus guanylate binding protein 2 (Gbp2), mRNA","Q63663",1212,0,"Guanylate-binding protein 1",".",".",".",".","pfam02841","GBP_C","Guanylate-binding protein, C-terminal domain. Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.","GO:0009617|response to bacterium;GO:0034504|protein localization to nucleus;GO:0035458|cellular response to interferon-beta;GO:0042832|defense response to protozoan;GO:0044406|adhesion of symbiont to host;GO:0050830|defense response to Gram-positive bacterium;GO:0071222|cellular response to lipopolysaccharide;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;","GO:0000139|Golgi membrane;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0031410|cytoplasmic vesicle;GO:0048471|perinuclear region of cytoplasm;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;","K20897","GBP2; guanylate-binding protein 2"]
["ENSRNOG00000032708",1731,143.7191494,135,8.684609155,16.54871818,4.048647568,0,0,"up","yes","RT1-Bb","protein_coding","chr20:4596559-4607597:-","gi|46237565|emb|CAE83945.1|",1143,{"v":1e-140,"d":"1.00E-140"},"RT1 class II, B beta [Rattus norvegicus]","gi|89214481|gb|AC120734.5|",4049,0,"Rattus norvegicus BAC CH230-220D1 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P29826",418,{"v":2E-132,"d":"2.00E-132"},"Rano class II histocompatibility antigen, B-1 beta chain",".",".",".",".","pfam00969","MHC_II_beta","Class II histocompatibility antigen, beta domain.","GO:0002250|adaptive immune response;GO:0002344|B cell affinity maturation;GO:0002381|immunoglobulin production involved in immunoglobulin mediated immune response;GO:0002503|peptide antigen assembly with MHC class II protein complex;GO:0002504|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;GO:0002579|positive regulation of antigen processing and presentation;GO:0002827|positive regulation of T-helper 1 type immune response;GO:0006955|immune response;GO:0006959|humoral immune response;GO:0019882|antigen processing and presentation;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0042130|negative regulation of T cell proliferation;GO:0046635|positive regulation of alpha-beta T cell activation;GO:0048002|antigen processing and presentation of peptide antigen;GO:0050832|defense response to fungus;GO:0050852|T cell receptor signaling pathway;GO:0050870|positive regulation of T cell activation;GO:0071315|cellular response to morphine;GO:0071346|cellular response to interferon-gamma;GO:0071385|cellular response to glucocorticoid stimulus;GO:0071549|cellular response to dexamethasone stimulus;","GO:0005769|early endosome;GO:0005771|multivesicular body;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0042613|MHC class II protein complex;","GO:0015643|toxic substance binding;GO:0023026|MHC class II protein complex binding;GO:0031625|ubiquitin protein ligase binding;GO:0042605|peptide antigen binding;GO:0044877|protein-containing complex binding;GO:1990405|protein antigen binding;","K06752","MHC2; MHC class II antigen"]
["ENSRNOG00000010319",2209,183.4058931,365,23.48060994,7.810950976,2.965498206,0,0,"up","yes","Lcp1","protein_coding","chr15:50488149-50544680:+","gi|564387027|ref|XP_006252380.1|",3378,0,"PREDICTED: plastin-2 isoform X2 [Rattus norvegicus]","gi|672078709|ref|XM_006252320.2|",3387,0,"PREDICTED: Rattus norvegicus lymphocyte cytosolic protein 1 (Lcp1), transcript variant X3, mRNA","Q61233",1286,0,"Plastin-2","SPBC1778.06c",441,{"v":9e-139,"d":"9.00E-139"},"COG5069","pfam00307","CH","Calponin homology (CH) domain. The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.","GO:0002286|T cell activation involved in immune response;GO:0010737|protein kinase A signaling;GO:0016477|cell migration;GO:0022617|extracellular matrix disassembly;GO:0031100|animal organ regeneration;GO:0033157|regulation of intracellular protein transport;GO:0051017|actin filament bundle assembly;GO:0051639|actin filament network formation;GO:0071803|positive regulation of podosome assembly;","GO:0001725|stress fiber;GO:0001726|ruffle;GO:0001891|phagocytic cup;GO:0002102|podosome;GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0005925|focal adhesion;GO:0015629|actin cytoskeleton;GO:0030175|filopodium;GO:0032432|actin filament bundle;GO:0048471|perinuclear region of cytoplasm;","GO:0003674|molecular_function;GO:0005178|integrin binding;GO:0005509|calcium ion binding;GO:0042802|identical protein binding;GO:0051015|actin filament binding;GO:0051020|GTPase binding;","K17276","LCP1, PLS2; plastin-2"]
["ENSRNOG00000032596",2238,185.8136663,397,25.53918396,7.275630519,2.86307228,0,0,"up","yes","RT1-T24-1","protein_coding","chr20:2718279-2776154:+","gi|57012364|ref|NP_001008858.1|",1733,0,"RT1 class I, locus T24, gene 1 [Rattus norvegicus]","gi|672085680|ref|XM_008772730.1|",1440,0,"PREDICTED: Rattus norvegicus RT1 class I, locus T24, gene 1 (RT1-T24-1), transcript variant X1, mRNA","P16391",342,{"v":1E-107,"d":"1.00E-107"},"RT1 class I histocompatibility antigen, AA alpha chain",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.","GO:0001916|positive regulation of T cell mediated cytotoxicity;GO:0002476|antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002486|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0006955|immune response;","GO:0005615|extracellular space;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0005102|signaling receptor binding;GO:0042605|peptide antigen binding;","K06751","MHC1; MHC class I antigen"]
["ENSRNOG00000024159",2675,222.0963169,658,42.32942833,5.246853683,2.391452559,0,0,"up","yes","Fcer1g","protein_coding","chr13:83649449-83671443:-","gi|58865384|ref|NP_001011907.1|",2498,0,"NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial precursor [Rattus norvegicus]","gi|564381782|ref|XM_003751277.2|",1602,0,"PREDICTED: Rattus norvegicus NADH dehydrogenase (ubiquinone) Fe-S protein 2 (Ndufs2), transcript variant X1, mRNA","Q641Y2",966,0,"NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial","RP354",570,0,"COG0649","pfam00346","Complex1_49kDa","Respiratory-chain NADH dehydrogenase, 49 Kd subunit.","GO:0001798|positive regulation of type IIa hypersensitivity;GO:0001805|positive regulation of type III hypersensitivity;GO:0001812|positive regulation of type I hypersensitivity;GO:0002283|neutrophil activation involved in immune response;GO:0002292|T cell differentiation involved in immune response;GO:0002431|Fc receptor mediated stimulatory signaling pathway;GO:0002554|serotonin secretion by platelet;GO:0006911|phagocytosis, engulfment;GO:0007165|signal transduction;GO:0007166|cell surface receptor signaling pathway;GO:0007229|integrin-mediated signaling pathway;GO:0010543|regulation of platelet activation;GO:0016064|immunoglobulin mediated immune response;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030316|osteoclast differentiation;GO:0030593|neutrophil chemotaxis;GO:0031623|receptor internalization;GO:0032733|positive regulation of interleukin-10 production;GO:0032753|positive regulation of interleukin-4 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032765|positive regulation of mast cell cytokine production;GO:0033026|negative regulation of mast cell apoptotic process;GO:0038094|Fc-gamma receptor signaling pathway;GO:0038095|Fc-epsilon receptor signaling pathway;GO:0038156|interleukin-3-mediated signaling pathway;GO:0042590|antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:0042742|defense response to bacterium;GO:0043306|positive regulation of mast cell degranulation;GO:0045087|innate immune response;GO:0045576|mast cell activation;GO:0050766|positive regulation of phagocytosis;GO:0050776|regulation of immune response;GO:0050778|positive regulation of immune response;GO:0071404|cellular response to low-density lipoprotein particle stimulus;GO:0072659|protein localization to plasma membrane;GO:2000010|positive regulation of protein localization to cell surface;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0032998|Fc-epsilon receptor I complex;","GO:0005515|protein binding;GO:0019767|IgE receptor activity;GO:0019863|IgE binding;GO:0019864|IgG binding;GO:0042802|identical protein binding;","K07983","FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma"]
["ENSRNOG00000019412",5950,494.0086301,3062,196.9798017,2.507915156,1.326488542,0,0,"up","yes","Rhbg","protein_coding","chr2:173704562-173717321:-","gi|34013522|ref|NP_898877.1|",1531,0,"ammonium transporter Rh type B precursor [Rattus norvegicus]","gi|51259432|gb|BC079365.1|",1238,0,"Rattus norvegicus Rh family, B glycoprotein, mRNA (cDNA clone MGC:94848 IMAGE:7109321), complete cds","Q68FT6",593,0,"Ammonium transporter Rh type B",".",".",".",".","pfam00909","Ammonium_transp","Ammonium Transporter Family.","GO:0008150|biological_process;GO:0015696|ammonium transport;GO:0070634|transepithelial ammonium transport;GO:0072488|ammonium transmembrane transport;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0014731|spectrin-associated cytoskeleton;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0030659|cytoplasmic vesicle membrane;GO:0046658|anchored component of plasma membrane;","GO:0003674|molecular_function;GO:0008519|ammonium transmembrane transporter activity;GO:0030506|ankyrin binding;","K06580","SLC42A, RHAG, RHBG, RHCG, CD241; ammonium transporter Rh"]
["ENSRNOG00000027811",2000,166.053321,312,20.07109671,8.273255987,3.048455222,0,0,"up","yes","Lilrb4","protein_coding","chr1:69805250-69810660:-","gi|564326168|ref|XP_006228300.1|",1885,0,"PREDICTED: leukocyte immunoglobulin-like receptor, subfamily B, member 4 isoform X2 [Rattus norvegicus]","gi|672034964|ref|XM_006228238.2|",1340,0,"PREDICTED: Rattus norvegicus leukocyte immunoglobulin-like receptor, subfamily B, member 4 (Lilrb4), transcript variant X3, mRNA","Q64281",446,{"v":3E-153,"d":"3.00E-153"},"Leukocyte immunoglobulin-like receptor subfamily B member 4",".",".",".",".","pfam13927","Ig_3","Immunoglobulin domain. This family contains immunoglobulin-like domains.","GO:0002507|tolerance induction;GO:0002669|positive regulation of T cell anergy;GO:0002725|negative regulation of T cell cytokine production;GO:0002774|Fc receptor mediated inhibitory signaling pathway;GO:0031623|receptor internalization;GO:0032682|negative regulation of chemokine production;GO:0032689|negative regulation of interferon-gamma production;GO:0032691|negative regulation of interleukin-1 beta production;GO:0032693|negative regulation of interleukin-10 production;GO:0032703|negative regulation of interleukin-2 production;GO:0032714|negative regulation of interleukin-5 production;GO:0032715|negative regulation of interleukin-6 production;GO:0042130|negative regulation of T cell proliferation;GO:0043124|negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043378|positive regulation of CD8-positive, alpha-beta T cell differentiation;GO:0043409|negative regulation of MAPK cascade;GO:0045584|negative regulation of cytotoxic T cell differentiation;GO:0045591|positive regulation of regulatory T cell differentiation;GO:0045671|negative regulation of osteoclast differentiation;GO:0046007|negative regulation of activated T cell proliferation;GO:0050860|negative regulation of T cell receptor signaling pathway;GO:0061099|negative regulation of protein tyrosine kinase activity;GO:0071659|negative regulation of IP-10 production;GO:0140105|interleukin-10-mediated signaling pathway;GO:1900016|negative regulation of cytokine production involved in inflammatory response;GO:1900181|negative regulation of protein localization to nucleus;GO:1902894|negative regulation of pri-miRNA transcription by RNA polymerase II;GO:2000272|negative regulation of signaling receptor activity;GO:2000524|negative regulation of T cell costimulation;","GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0019903|protein phosphatase binding;GO:0030293|transmembrane receptor protein tyrosine kinase inhibitor activity;GO:0030547|receptor inhibitor activity;","K06512","LILR, CD85; leukocyte immunoglobulin-like receptor"]
["ENSRNOG00000022839",1432,118.8941779,57,3.666834977,32.42419652,5.018998919,0,0,"up","yes","Ifit3","protein_coding","chr1:232114166-232119307:+","gi|56090427|ref|NP_001007695.1|",2187,0,"interferon-induced protein with tetratricopeptide repeats 3 [Rattus norvegicus]","gi|56090426|ref|NM_001007694.1|",1989,0,"Rattus norvegicus interferon-induced protein with tetratricopeptide repeats 3 (Ifit3), mRNA","Q64345",688,0,"Interferon-induced protein with tetratricopeptide repeats 3",".",".",".",".","pfam13424","TPR_12","Tetratricopeptide repeat.","GO:0008285|negative regulation of cell proliferation;GO:0009615|response to virus;GO:0009617|response to bacterium;GO:0035457|cellular response to interferon-alpha;GO:0035458|cellular response to interferon-beta;GO:0035634|response to stilbenoid;GO:0043066|negative regulation of apoptotic process;GO:0051607|defense response to virus;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;","GO:0003723|RNA binding;GO:0042802|identical protein binding;","K24849","IFIT3; interferon-induced protein with tetratricopeptide repeats 3"]
["ENSRNOG00000001963",1358,112.750205,42,2.701878404,41.7303032,5.383023498,0,0,"up","yes","Mx2","protein_coding","chr11:36906111-36930342:+","gi|71534283|ref|NP_599177.2|",3379,0,"interferon-induced GTP-binding protein Mx2 [Rattus norvegicus]","gi|56722|emb|X52712.1|",2150,0,"Rat mRNA for Mx2 protein","P18590",1302,0,"Interferon-induced GTP-binding protein Mx3","YKR001c",231,{"v":4e-64,"d":"4.00E-64"},"COG0699","pfam01031","Dynamin_M","Dynamin central region. This region lies between the GTPase domain, see pfam00350, and the pleckstrin homology (PH) domain, see pfam00169.","GO:0009615|response to virus;GO:0016197|endosomal transport;GO:0034340|response to type I interferon;GO:0035455|response to interferon-alpha;GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0046822|regulation of nucleocytoplasmic transport;GO:0051607|defense response to virus;GO:0051726|regulation of cell cycle;GO:0071357|cellular response to type I interferon;GO:1901253|negative regulation of intracellular transport of viral material;","GO:0005634|nucleus;GO:0005643|nuclear pore;GO:0005737|cytoplasm;GO:0005874|microtubule;GO:0016020|membrane;GO:0070382|exocytic vesicle;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0008017|microtubule binding;","K14754","MX; interferon-induced GTP-binding protein Mx"]
["ENSRNOG00000028814",1451,120.4716844,115,7.398000391,16.28435767,4.025414909,0,0,"up","yes","Oasl2","protein_coding","chr12:41709435-41722547:-","gi|672073310|ref|XP_008767549.1|",2522,0,"PREDICTED: 2'-5'-oligoadenylate synthase-like protein 2 isoform X1 [Rattus norvegicus]","gi|672073309|ref|XM_008769327.1|",2214,0,"PREDICTED: Rattus norvegicus 2'-5' oligoadenylate synthetase-like 2 (Oasl2), transcript variant X1, mRNA","Q5MYT9",968,0,"2'-5'-oligoadenylate synthase-like protein 2",".",".",".",".","pfam10421","OAS1_C","2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus. This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between 320 and 344 at the extreme C-terminal end. Oligoadenylate synthetases are antiviral enzymes that counteract vial attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesize 2'.5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication. This domain is often associated with NTP_transf_2 pfam01909.","GO:0009615|response to virus;GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0051607|defense response to virus;GO:0060700|regulation of ribonuclease activity;","GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0016020|membrane;","GO:0001730|2'-5'-oligoadenylate synthetase activity;GO:0003725|double-stranded RNA binding;GO:0005524|ATP binding;GO:0046872|metal ion binding;","K14608","OASL; 2'-5'-oligoadenylate synthase-like protein"]
["ENSRNOG00000002217",1237,102.7039791,20,1.286608764,79.82533772,6.318774846,0,0,"up","yes","Plac8","protein_coding","chr14:9063048-9074264:+","gi|157820945|ref|NP_001101823.1|",517,{"v":8e-64,"d":"8.00E-64"},"placenta-specific gene 8 protein [Rattus norvegicus]","gi|157820944|ref|NM_001108353.1|",605,0,"Rattus norvegicus placenta-specific 8 (Plac8), mRNA","Q9JI48",202,{"v":1e-64,"d":"1.00E-64"},"Placenta-specific gene 8 protein",".",".",".",".","pfam04749","PLAC8","PLAC8 family. This family includes the Placenta-specific gene 8 protein.","GO:0008284|positive regulation of cell proliferation;GO:0009409|response to cold;GO:0040015|negative regulation of multicellular organism growth;GO:0042742|defense response to bacterium;GO:0043066|negative regulation of apoptotic process;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050873|brown fat cell differentiation;GO:0120162|positive regulation of cold-induced thermogenesis;",".","GO:0003682|chromatin binding;",".","."]
["ENSRNOG00000001187",1315,109.1800586,82,5.275095931,20.69726504,4.371368236,0,0,"up","yes","Oasl","protein_coding","chr12:41682900-41695641:-","gi|403399503|sp|G3V645.1|OASL1_RAT",2628,0,"RecName: Full=2'-5'-oligoadenylate synthase-like protein 1","gi|57527343|ref|NM_001009681.1|",1977,0,"Rattus norvegicus 2'-5'-oligoadenylate synthetase-like (Oasl), mRNA","G3V645",1016,0,"2'-5'-oligoadenylate synthase-like protein 1",".",".",".",".","pfam10421","OAS1_C","2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus. This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between 320 and 344 at the extreme C-terminal end. Oligoadenylate synthetases are antiviral enzymes that counteract vial attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesize 2'.5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication. This domain is often associated with NTP_transf_2 pfam01909.","GO:0009615|response to virus;GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0051607|defense response to virus;GO:0060700|regulation of ribonuclease activity;GO:0070106|interleukin-27-mediated signaling pathway;GO:1900246|positive regulation of RIG-I signaling pathway;","GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016020|membrane;","GO:0003677|DNA binding;GO:0003725|double-stranded RNA binding;","K14608","OASL; 2'-5'-oligoadenylate synthase-like protein"]
["ENSRNOG00000025695",5472,454.3218864,2983,191.8976971,2.367521306,1.243377409,0,0,"up","yes","Tns3","protein_coding","chr14:83173649-83405998:-","gi|672076878|ref|XP_008768558.1|",7631,0,"PREDICTED: tensin-3 isoform X9 [Rattus norvegicus]","gi|672076877|ref|XM_008770336.1|",8182,0,"PREDICTED: Rattus norvegicus tensin 3 (Tns3), transcript variant X9, mRNA","Q5SSZ5",2715,0,"Tensin-3","SPBC609.02",84.3,{"v":8e-16,"d":"8.00E-16"},"COG2453","pfam08416","PTB","Phosphotyrosine-binding domain. The phosphotyrosine-binding domain (PTB, also phosphotyrosine-interaction or PI domain) in the protein tensin tends to be found at the C-terminus. Tensin is a multi-domain protein that binds to actin filaments and functions as a focal-adhesion molecule (focal adhesions are regions of plasma membrane through which cells attach to the extracellular matrix). Human tensin has actin-binding sites, an SH2 (pfam00017) domain and a region similar to the tumor suppressor PTEN. The PTB domain interacts with the cytoplasmic tails of beta integrin by binding to an NPXY motif.","GO:0008284|positive regulation of cell proliferation;GO:0016311|dephosphorylation;GO:0016477|cell migration;GO:0035556|intracellular signal transduction;GO:0048286|lung alveolus development;","GO:0005829|cytosol;GO:0005925|focal adhesion;","GO:0016791|phosphatase activity;","K18080","TNS; tensin"]
["ENSRNOG00000011054",1837,152.5199754,341,21.93667942,6.95273758,2.797581138,0,0,"up","yes","Laptm5","protein_coding","chr5:143087759-143109807:+","gi|40254749|ref|NP_445990.2|",1091,{"v":3e-138,"d":"3.00E-138"},"lysosomal-associated transmembrane protein 5 [Rattus norvegicus]","gi|40254748|ref|NM_053538.2|",1978,0,"Rattus norvegicus lysosomal protein transmembrane 5 (Laptm5), mRNA","Q61168",400,{"v":2e-130,"d":"2.00E-130"},"Lysosomal-associated transmembrane protein 5",".",".",".",".","pfam03821","Mtp","Golgi 4-transmembrane spanning transporter.","GO:0002357|defense response to tumor cell;GO:0002720|positive regulation of cytokine production involved in immune response;GO:0006622|protein targeting to lysosome;GO:0006886|intracellular protein transport;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0012502|induction of programmed cell death;GO:0031398|positive regulation of protein ubiquitination;GO:0032689|negative regulation of interferon-gamma production;GO:0032703|negative regulation of interleukin-2 production;GO:0032735|positive regulation of interleukin-12 production;GO:0032755|positive regulation of interleukin-6 production;GO:0043410|positive regulation of MAPK cascade;GO:0046007|negative regulation of activated T cell proliferation;GO:0050860|negative regulation of T cell receptor signaling pathway;GO:0050868|negative regulation of T cell activation;GO:0050869|negative regulation of B cell activation;GO:0060907|positive regulation of macrophage cytokine production;GO:0061462|protein localization to lysosome;GO:0090160|Golgi to lysosome transport;GO:0097214|positive regulation of lysosomal membrane permeability;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1903052|positive regulation of proteolysis involved in cellular protein catabolic process;GO:1903265|positive regulation of tumor necrosis factor-mediated signaling pathway;GO:1904093|negative regulation of autophagic cell death;GO:1990830|cellular response to leukemia inhibitory factor;GO:2000060|positive regulation of ubiquitin-dependent protein catabolic process;GO:2000646|positive regulation of receptor catabolic process;","GO:0005764|lysosome;GO:0005765|lysosomal membrane;GO:0005829|cytosol;GO:0005887|integral component of plasma membrane;GO:0030133|transport vesicle;GO:0031410|cytoplasmic vesicle;GO:0032991|protein-containing complex;GO:0048471|perinuclear region of cytoplasm;","GO:0019899|enzyme binding;GO:0031625|ubiquitin protein ligase binding;GO:0140036|ubiquitin-dependent protein binding;","K12387","LAPTM; lysosomal-associated transmembrane protein"]
["ENSRNOG00000000655",1511,125.4532841,190,12.22278326,10.26388846,3.359505493,0,0,"up","yes","Ptprc","protein_coding","chr13:49596193-49708692:-","gi|56559|emb|CAA68272.1|",5958,0,"unnamed protein product [Rattus norvegicus]","gi|205146|gb|M18349.1|RATLCAG1",8442,0,"Rat leukocyte common antigen (L-CA) gene, exons 1 through 5","P04157",2296,0,"Receptor-type tyrosine-protein phosphatase C","SPAC19D5.01",135,{"v":8e-31,"d":"8.00E-31"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0001779|natural killer cell differentiation;GO:0001915|negative regulation of T cell mediated cytotoxicity;GO:0001916|positive regulation of T cell mediated cytotoxicity;GO:0001960|negative regulation of cytokine-mediated signaling pathway;GO:0002244|hematopoietic progenitor cell differentiation;GO:0002639|positive regulation of immunoglobulin production;GO:0002711|positive regulation of T cell mediated immunity;GO:0002923|regulation of humoral immune response mediated by circulating immunoglobulin;GO:0002925|positive regulation of humoral immune response mediated by circulating immunoglobulin;GO:0006469|negative regulation of protein kinase activity;GO:0006470|protein dephosphorylation;GO:0006933|negative regulation of cell adhesion involved in substrate-bound cell migration;GO:0007159|leukocyte cell-cell adhesion;GO:0010332|response to gamma radiation;GO:0010468|regulation of gene expression;GO:0016311|dephosphorylation;GO:0030183|B cell differentiation;GO:0030217|T cell differentiation;GO:0030890|positive regulation of B cell proliferation;GO:0031668|cellular response to extracellular stimulus;GO:0031953|negative regulation of protein autophosphorylation;GO:0032677|regulation of interleukin-8 production;GO:0032703|negative regulation of interleukin-2 production;GO:0032743|positive regulation of interleukin-2 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0034113|heterotypic cell-cell adhesion;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0035584|calcium-mediated signaling using intracellular calcium source;GO:0042098|T cell proliferation;GO:0042100|B cell proliferation;GO:0042102|positive regulation of T cell proliferation;GO:0043406|positive regulation of MAP kinase activity;GO:0043410|positive regulation of MAPK cascade;GO:0044770|cell cycle phase transition;GO:0044855|plasma membrane raft distribution;GO:0045059|positive thymic T cell selection;GO:0045060|negative thymic T cell selection;GO:0045582|positive regulation of T cell differentiation;GO:0045588|positive regulation of gamma-delta T cell differentiation;GO:0046425|regulation of JAK-STAT cascade;GO:0046641|positive regulation of alpha-beta T cell proliferation;GO:0048304|positive regulation of isotype switching to IgG isotypes;GO:0048539|bone marrow development;GO:0048864|stem cell development;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050732|negative regulation of peptidyl-tyrosine phosphorylation;GO:0050764|regulation of phagocytosis;GO:0050852|T cell receptor signaling pathway;GO:0050853|B cell receptor signaling pathway;GO:0050857|positive regulation of antigen receptor-mediated signaling pathway;GO:0051209|release of sequestered calcium ion into cytosol;GO:0051607|defense response to virus;GO:0051726|regulation of cell cycle;GO:0061097|regulation of protein tyrosine kinase activity;GO:0061099|negative regulation of protein tyrosine kinase activity;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:1903615|positive regulation of protein tyrosine phosphatase activity;GO:1905451|positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis;GO:2000473|positive regulation of hematopoietic stem cell migration;GO:2000648|positive regulation of stem cell proliferation;GO:2001236|regulation of extrinsic apoptotic signaling pathway;GO:2001238|positive regulation of extrinsic apoptotic signaling pathway;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005925|focal adhesion;GO:0009897|external side of plasma membrane;GO:0009898|cytoplasmic side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0032059|bleb;GO:0045121|membrane raft;GO:0071944|cell periphery;GO:0098857|membrane microdomain;","GO:0004725|protein tyrosine phosphatase activity;GO:0005001|transmembrane receptor protein tyrosine phosphatase activity;GO:0005102|signaling receptor binding;GO:0005515|protein binding;GO:0008201|heparin binding;GO:0019887|protein kinase regulator activity;GO:0019901|protein kinase binding;GO:0030506|ankyrin binding;GO:0030507|spectrin binding;GO:0043395|heparan sulfate proteoglycan binding;","K06478","PTPRC, CD45; receptor-type tyrosine-protein phosphatase C [EC:3.1.3.48]"]
["ENSRNOG00000005871",1261,104.6966189,79,5.082104617,20.60103576,4.364644968,0,0,"up","yes","Il1rn","protein_coding","chr3:7111550-7127445:+","gi|564339611|ref|XP_006233698.1|",857,{"v":3e-108,"d":"3.00E-108"},"PREDICTED: interleukin-1 receptor antagonist protein isoform X1 [Rattus norvegicus]","gi|672044714|ref|XM_006233636.2|",1947,0,"PREDICTED: Rattus norvegicus interleukin 1 receptor antagonist (Il1rn), transcript variant X1, mRNA","P25086",329,{"v":2E-107,"d":"2.00E-107"},"Interleukin-1 receptor antagonist protein",".",".",".",".","pfam00340","IL1","Interleukin-1 / 18. This family includes interleukin-1 and interleukin-18.","GO:0001660|fever generation;GO:0002437|inflammatory response to antigenic stimulus;GO:0002439|chronic inflammatory response to antigenic stimulus;GO:0006629|lipid metabolic process;GO:0006953|acute-phase response;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007165|signal transduction;GO:0007565|female pregnancy;GO:0007613|memory;GO:0009410|response to xenobiotic stimulus;GO:0009968|negative regulation of signal transduction;GO:0010243|response to organonitrogen compound;GO:0014050|negative regulation of glutamate secretion;GO:0014070|response to organic cyclic compound;GO:0014823|response to activity;GO:0019233|sensory perception of pain;GO:0019752|carboxylic acid metabolic process;GO:0030073|insulin secretion;GO:0030336|negative regulation of cell migration;GO:0032496|response to lipopolysaccharide;GO:0034115|negative regulation of heterotypic cell-cell adhesion;GO:0042594|response to starvation;GO:0043066|negative regulation of apoptotic process;GO:0043507|positive regulation of JUN kinase activity;GO:0045837|negative regulation of membrane potential;GO:0051384|response to glucocorticoid;GO:0070555|response to interleukin-1;GO:0070670|response to interleukin-4;GO:0071874|cellular response to norepinephrine stimulus;GO:2000660|negative regulation of interleukin-1-mediated signaling pathway;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0031982|vesicle;","GO:0005125|cytokine activity;GO:0005149|interleukin-1 receptor binding;GO:0005150|interleukin-1, type I receptor binding;GO:0005151|interleukin-1, type II receptor binding;GO:0005152|interleukin-1 receptor antagonist activity;GO:0045352|interleukin-1 type I receptor antagonist activity;GO:0045353|interleukin-1 type II receptor antagonist activity;","K05481","IL1RN, IL1F3; interleukin 1 receptor antagonist"]
["ENSRNOG00000012660",1135,94.2352597,59,3.795495853,24.82818144,4.633906689,{"v":1.2774e-294,"d":"1.28E-294"},{"v":8.6893e-293,"d":"8.69E-293"},"up","yes","Postn","protein_coding","chr2:138527696-138559099:+","gi|564336409|ref|XP_006232397.1|",4144,0,"PREDICTED: periostin isoform X1 [Rattus norvegicus]","gi|672042357|ref|XM_006232335.2|",3278,0,"PREDICTED: Rattus norvegicus periostin, osteoblast specific factor (Postn), transcript variant X1, mRNA","Q62009",1575,0,"Periostin","all4647",79,{"v":1e-15,"d":"1.00E-15"},"COG2335","pfam02469","Fasciclin","Fasciclin domain. This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.","GO:0001666|response to hypoxia;GO:0001953|negative regulation of cell-matrix adhesion;GO:0003073|regulation of systemic arterial blood pressure;GO:0007155|cell adhesion;GO:0008593|regulation of Notch signaling pathway;GO:0009612|response to mechanical stimulus;GO:0009888|tissue development;GO:0014850|response to muscle activity;GO:0014911|positive regulation of smooth muscle cell migration;GO:0030198|extracellular matrix organization;GO:0032355|response to estradiol;GO:0042060|wound healing;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0071307|cellular response to vitamin K;GO:0071356|cellular response to tumor necrosis factor;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:1900025|negative regulation of substrate adhesion-dependent cell spreading;GO:1990138|neuron projection extension;GO:1990523|bone regeneration;GO:2000343|positive regulation of chemokine (C-X-C motif) ligand 2 production;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005802|trans-Golgi network;GO:0031012|extracellular matrix;GO:0031594|neuromuscular junction;GO:0062023|collagen-containing extracellular matrix;","GO:0003674|molecular_function;GO:0008201|heparin binding;GO:0046872|metal ion binding;GO:0050839|cell adhesion molecule binding;","K24790","POSTN; periostin"]
["ENSRNOG00000027271",4751,394.4596642,2564,164.9432435,2.391487252,1.257908101,{"v":6.7535e-293,"d":"6.75E-293"},{"v":4.5456e-291,"d":"4.55E-291"},"up","yes","RGD1359290","protein_coding","chr10:92373775-92389465:+","gi|114145792|ref|NP_001041363.1|",1110,{"v":7e-152,"d":"7.00E-152"},"Ribosomal_L22 domain containing protein RGD1359290 [Rattus norvegicus]","gi|114145791|ref|NM_001047898.1|",663,0,"Rattus norvegicus Ribosomal_L22 domain containing protein RGD1359290 (RGD1359290), mRNA","P24049",244,{"v":4e-80,"d":"4.00E-80"},"60S ribosomal protein L17","YKL180w",150,{"v":5e-44,"d":"5.00E-44"},"COG0091","pfam00237","Ribosomal_L22","Ribosomal protein L22p/L17e. This family includes L22 from prokaryotes and chloroplasts and L17 from eukaryotes.","GO:0002181|cytoplasmic translation;","GO:0022625|cytosolic large ribosomal subunit;","GO:0003735|structural constituent of ribosome;",".","."]
["ENSRNOG00000019377",4729,392.6330776,2548,163.9139565,2.395360871,1.26024302,{"v":2.1669e-292,"d":"2.17E-292"},{"v":1.4432E-290,"d":"1.44E-290"},"up","yes","Amh","protein_coding","chr7:8906836-8909282:-","gi|25742760|ref|NP_037034.1|",2364,0,"muellerian-inhibiting factor precursor [Rattus norvegicus]","gi|25742759|ref|NM_012902.1|",1662,0,"Rattus norvegicus anti-Mullerian hormone (Amh), mRNA","P49000",915,0,"Muellerian-inhibiting factor",".",".",".",".","pfam04709","AMH_N","Anti-Mullerian hormone, N terminal region. Anti-Mullerian hormone, AMH is a signalling molecule involved in male and female sexual differentiation. Defects in synthesis or action of AMH cause persistent Mullerian duct syndrome (PMDS), a rare form of male pseudohermaphroditism. This family represents the N terminal part of the protein, which is not thought to be essential for activity. AMH contains a TGF-beta domain (pfam00019), at the C terminus.","GO:0001546|preantral ovarian follicle growth;GO:0001655|urogenital system development;GO:0001880|Mullerian duct regression;GO:0007165|signal transduction;GO:0007506|gonadal mesoderm development;GO:0007568|aging;GO:0009410|response to xenobiotic stimulus;GO:0010628|positive regulation of gene expression;GO:0014070|response to organic cyclic compound;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:2000355|negative regulation of ovarian follicle development;","GO:0005615|extracellular space;GO:0005737|cytoplasm;","GO:0005102|signaling receptor binding;GO:0005160|transforming growth factor beta receptor binding;GO:0005515|protein binding;GO:0008083|growth factor activity;","K04665","AMH; anti-mullerian hormone"]
["ENSRNOG00000022256",1218,101.1264725,100,6.433043818,15.71984824,3.974515384,{"v":2.5276E-292,"d":"2.53E-292"},{"v":1.6661e-290,"d":"1.67E-290"},"up","yes","Cxcl10","protein_coding","chr14:15704758-15706975:+","gi|146345511|sp|P48973.2|CXL10_RAT",421,{"v":2e-47,"d":"2.00E-47"},"RecName: Full=C-X-C motif chemokine 10; AltName: Full=10 kDa interferon gamma-induced protein; Short=Gamma-IP10; Short=IP-10; AltName: Full=Interferon-inducible protein 10; AltName: Full=Protein Mob-1; AltName: Full=Small-inducible cytokine B10; Flags: Precursor","gi|298906686|emb|FQ225221.1|",1154,0,"Rattus norvegicus TL0AEA54YL10 mRNA sequence","P48973",166,{"v":7e-49,"d":"7.00E-49"},"C-X-C motif chemokine 10",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0002690|positive regulation of leukocyte chemotaxis;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0008284|positive regulation of cell proliferation;GO:0009409|response to cold;GO:0009615|response to virus;GO:0009617|response to bacterium;GO:0010332|response to gamma radiation;GO:0010818|T cell chemotaxis;GO:0010819|regulation of T cell chemotaxis;GO:0010996|response to auditory stimulus;GO:0016525|negative regulation of angiogenesis;GO:0030335|positive regulation of cell migration;GO:0030593|neutrophil chemotaxis;GO:0031640|killing of cells of other organism;GO:0032496|response to lipopolysaccharide;GO:0033280|response to vitamin D;GO:0034605|cellular response to heat;GO:0042118|endothelial cell activation;GO:0042127|regulation of cell proliferation;GO:0042981|regulation of apoptotic process;GO:0045662|negative regulation of myoblast differentiation;GO:0050918|positive chemotaxis;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;GO:0051607|defense response to virus;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098|chemokine-mediated signaling pathway;GO:0071222|cellular response to lipopolysaccharide;GO:0090026|positive regulation of monocyte chemotaxis;GO:0098586|cellular response to virus;GO:1901509|regulation of endothelial tube morphogenesis;GO:1901740|negative regulation of myoblast fusion;GO:2000406|positive regulation of T cell migration;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0009897|external side of plasma membrane;","GO:0005125|cytokine activity;GO:0008009|chemokine activity;GO:0008201|heparin binding;GO:0042056|chemoattractant activity;GO:0045236|CXCR chemokine receptor binding;GO:0048248|CXCR3 chemokine receptor binding;","K12671","CXCL10, IP10; C-X-C motif chemokine 10"]
["ENSRNOG00000029658",3347,277.8902328,1449,93.21480493,2.981181294,1.575884112,{"v":4.7902e-290,"d":"4.79E-290"},{"v":3.0938E-288,"d":"3.09E-288"},"up","yes","Rnf213","protein_coding","chr10:104656883-104757918:+","gi|672025745|ref|XP_008774086.1|",26896,0,"PREDICTED: E3 ubiquitin-protein ligase RNF213 isoform X1 [Rattus norvegicus]","gi|672025744|ref|XM_008775864.1|",14394,0,"PREDICTED: Rattus norvegicus ring finger protein 213 (Rnf213), transcript variant X1, mRNA","E9Q555",8763,0,"E3 ubiquitin-protein ligase RNF213",".",".",".",".","pfam13639","zf-RING_2","Ring finger domain.","GO:0001525|angiogenesis;GO:0002040|sprouting angiogenesis;GO:0006511|ubiquitin-dependent protein catabolic process;GO:0016567|protein ubiquitination;GO:0051260|protein homooligomerization;GO:0051865|protein autoubiquitination;GO:2000051|negative regulation of non-canonical Wnt signaling pathway;","GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004842|ubiquitin-protein transferase activity;GO:0046872|metal ion binding;","K22754","RNF213; E3 ubiquitin-protein ligase RNF213 [EC:2.3.2.27]"]
["ENSRNOG00000021243",1114,92.49169982,62,3.988487167,23.18966965,4.535410363,{"v":1.1004e-286,"d":"1.10E-286"},{"v":7.036e-285,"d":"7.04E-285"},"up","yes","Siglec1","protein_coding","chr3:118287988-118306850:-","gi|564343027|ref|XP_006235086.1|",8540,0,"PREDICTED: sialoadhesin isoform X1 [Rattus norvegicus]","gi|672046902|ref|XM_006235024.2|",6172,0,"PREDICTED: Rattus norvegicus sialic acid binding Ig-like lectin 1, sialoadhesin (Siglec1), transcript variant X1, mRNA","Q62230",2862,0,"Sialoadhesin",".",".",".",".","pfam08205","C2-set_2","CD80-like C2-set immunoglobulin domain. These domains belong to the immunoglobulin superfamily.","GO:0046718|viral entry into host cell;GO:0050765|negative regulation of phagocytosis;GO:0070234|positive regulation of T cell apoptotic process;GO:0072583|clathrin-dependent endocytosis;GO:0075512|clathrin-dependent endocytosis of virus by host cell;GO:2001238|positive regulation of extrinsic apoptotic signaling pathway;","GO:0005769|early endosome;GO:0005770|late endosome;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030139|endocytic vesicle;","GO:0030246|carbohydrate binding;GO:0046790|virion binding;","K06548","SN, SIGLEC1, CD169; sialoadhesin"]
["ENSRNOG00000003902",3431,284.8644723,1543,99.26186612,2.869827895,1.52096422,{"v":2.4072e-282,"d":"2.41E-282"},1.48E-280,"up","yes","Fabp6","protein_coding","chr10:28063603-28068282:-","gi|149052320|gb|EDM04137.1|",672,{"v":8e-88,"d":"8.00E-88"},"fatty acid binding protein 6, ileal (gastrotropin) [Rattus norvegicus]","gi|8393345|ref|NM_017098.1|",484,0,"Rattus norvegicus fatty acid binding protein 6 (Fabp6), mRNA","P80020",259,{"v":2E-87,"d":"2.00E-87"},"Gastrotropin",".",".",".",".","pfam14651","Lipocalin_7","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2).","GO:0006869|lipid transport;GO:0008202|steroid metabolic process;","GO:0005829|cytosol;GO:0016020|membrane;","GO:0005504|fatty acid binding;GO:0008289|lipid binding;","K08755","FABP6; fatty acid-binding protein 6, ileal (gastrotropin)"]
["ENSRNOG00000049771",3997,331.8575621,1995,128.3392242,2.585784387,1.370601982,{"v":2.078e-281,"d":"2.08E-281"},{"v":1.2654E-279,"d":"1.27E-279"},"up","yes","Gstt1","protein_coding","chr20:12856669-12873585:+","gi|16757988|ref|NP_445745.1|",1277,{"v":3E-175,"d":"3.00E-175"},"glutathione S-transferase theta-1 [Rattus norvegicus]","gi|55926212|ref|NM_053293.2|",943,0,"Rattus norvegicus glutathione S-transferase theta 1 (Gstt1), mRNA","Q01579",496,{"v":9e-177,"d":"9.00E-177"},"Glutathione S-transferase theta-1","SMb20420",70.9,{"v":1E-13,"d":"1.00E-13"},"COG0625","pfam02798","GST_N","Glutathione S-transferase, N-terminal domain. Function: conjugation of reduced glutathione to a variety of targets. Also included in the alignment, but are not GSTs: * S-crystallins from squid. Similarity to GST previously noted. * Eukaryotic elongation factors 1-gamma. Not known to have GST activity; similarity not previously recognized. * HSP26 family of stress-related proteins. including auxin-regulated proteins in plants and stringent starvation proteins in Escherichia coli. Not known to have GST activity. Similarity not previously recognized. The glutathione molecule binds in a cleft between N and C-terminal domains - the catalytically important residues are proposed to reside in the N-terminal domain.","GO:0006304|DNA modification;GO:0006749|glutathione metabolic process;GO:0007568|aging;GO:0009410|response to xenobiotic stimulus;GO:0009751|response to salicylic acid;GO:0010269|response to selenium ion;GO:0014070|response to organic cyclic compound;GO:0018900|dichloromethane metabolic process;GO:0033197|response to vitamin E;GO:0098869|cellular oxidant detoxification;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004364|glutathione transferase activity;GO:0004602|glutathione peroxidase activity;GO:0047651|alkylhalidase activity;","K00799","GST, gst; glutathione S-transferase [EC:2.5.1.18]"]
["ENSRNOG00000019430",1332,110.5915118,187,12.02979194,9.193135872,3.200557063,{"v":3.0702e-271,"d":"3.07E-271"},{"v":1.7846e-269,"d":"1.78E-269"},"up","yes","Coro1a","protein_coding","chr1:181295562-181300534:-","gi|18426834|ref|NP_569095.1|",2455,0,"coronin-1A [Rattus norvegicus]","gi|298889768|emb|FQ226941.1|",1610,0,"Rattus norvegicus TL0AEA15YO22 mRNA sequence","Q91ZN1",950,0,"Coronin-1A",".",".",".",".","pfam08954","DUF1900","Domain of unknown function (DUF1900). This domain is predominantly found in the structural protein coronin, and is duplicated in some sequences. It has no known function.","GO:0001845|phagolysosome assembly;GO:0006816|calcium ion transport;GO:0006909|phagocytosis;GO:0007015|actin filament organization;GO:0008064|regulation of actin polymerization or depolymerization;GO:0008150|biological_process;GO:0008360|regulation of cell shape;GO:0016477|cell migration;GO:0030036|actin cytoskeleton organization;GO:0030217|T cell differentiation;GO:0030335|positive regulation of cell migration;GO:0030595|leukocyte chemotaxis;GO:0030833|regulation of actin filament polymerization;GO:0031339|negative regulation of vesicle fusion;GO:0031589|cell-substrate adhesion;GO:0032796|uropod organization;GO:0032956|regulation of actin cytoskeleton organization;GO:0034097|response to cytokine;GO:0038180|nerve growth factor signaling pathway;GO:0042102|positive regulation of T cell proliferation;GO:0043029|T cell homeostasis;GO:0043320|natural killer cell degranulation;GO:0043524|negative regulation of neuron apoptotic process;GO:0048873|homeostasis of number of cells within a tissue;GO:0050870|positive regulation of T cell activation;GO:0050918|positive chemotaxis;GO:0051126|negative regulation of actin nucleation;GO:0051279|regulation of release of sequestered calcium ion into cytosol;GO:0061502|early endosome to recycling endosome transport;GO:0071353|cellular response to interleukin-4;","GO:0001772|immunological synapse;GO:0001891|phagocytic cup;GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005769|early endosome;GO:0005829|cytosol;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0015629|actin cytoskeleton;GO:0030027|lamellipodium;GO:0030424|axon;GO:0030670|phagocytic vesicle membrane;GO:0030864|cortical actin cytoskeleton;GO:0031252|cell leading edge;GO:0032426|stereocilium tip;GO:0032991|protein-containing complex;GO:0045202|synapse;GO:0045335|phagocytic vesicle;GO:0098978|glutamatergic synapse;","GO:0003674|molecular_function;GO:0003779|actin binding;GO:0003785|actin monomer binding;GO:0008022|protein C-terminus binding;GO:0008092|cytoskeletal protein binding;GO:0032036|myosin heavy chain binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0043548|phosphatidylinositol 3-kinase binding;GO:0051015|actin filament binding;","K13882","CORO1A; coronin-1A"]
["ENSRNOG00000003189",1272,105.6099122,174,11.19349624,9.434935241,3.238012616,{"v":8.9397e-262,"d":"8.94E-262"},{"v":4.9706e-260,"d":"4.97E-260"},"up","yes","Cited1","protein_coding","chrX:67350373-67355162:-","gi|564399592|ref|XP_006257159.1|",848,{"v":2e-110,"d":"2.00E-110"},"PREDICTED: cbp/p300-interacting transactivator 1 isoform X2 [Rattus norvegicus]","gi|67972659|ref|NM_172055.2|",834,0,"Rattus norvegicus Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 (Cited1), mRNA","P97769",263,{"v":1e-85,"d":"1.00E-85"},"Cbp/p300-interacting transactivator 1",".",".",".",".","pfam04487","CITED","CITED. CITED, CBP/p300-interacting transactivator with ED-rich tail, are characterized by a conserved 32-amino acid sequence at the C-terminus. CITED proteins do not bind DNA directly and are thought to function as transcriptional co-activators.","GO:0000578|embryonic axis specification;GO:0001570|vasculogenesis;GO:0001658|branching involved in ureteric bud morphogenesis;GO:0001890|placenta development;GO:0003340|negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0006913|nucleocytoplasmic transport;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0007420|brain development;GO:0010628|positive regulation of gene expression;GO:0030318|melanocyte differentiation;GO:0032496|response to lipopolysaccharide;GO:0032868|response to insulin;GO:0034097|response to cytokine;GO:0034341|response to interferon-gamma;GO:0042438|melanin biosynthetic process;GO:0042981|regulation of apoptotic process;GO:0043473|pigmentation;GO:0043524|negative regulation of neuron apoptotic process;GO:0043627|response to estrogen;GO:0045668|negative regulation of osteoblast differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051591|response to cAMP;GO:0060395|SMAD protein signal transduction;GO:0060711|labyrinthine layer development;GO:0060712|spongiotrophoblast layer development;GO:0070555|response to interleukin-1;GO:0070669|response to interleukin-2;GO:0070670|response to interleukin-4;GO:0070741|response to interleukin-6;GO:0071104|response to interleukin-9;GO:0071105|response to interleukin-11;GO:0071107|response to parathyroid hormone;GO:0071559|response to transforming growth factor beta;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0003682|chromatin binding;GO:0003713|transcription coactivator activity;GO:0008022|protein C-terminus binding;GO:0042803|protein homodimerization activity;GO:0050693|LBD domain binding;GO:0070410|co-SMAD binding;","K22527","CITED1; Cbp/p300-interacting transactivator 1"]
["ENSRNOG00000014956",1238,102.7870057,171,11.00050493,9.343844341,3.224016241,{"v":7.1291e-254,"d":"7.13E-254"},{"v":3.8961e-252,"d":"3.90E-252"},"up","yes","Slc11a1","protein_coding","chr9:75957316-75968101:+","gi|564369044|ref|XP_006245281.1|",2746,0,"PREDICTED: natural resistance-associated macrophage protein 1 isoform X1 [Rattus norvegicus]","gi|672065608|ref|XM_006245219.2|",1886,0,"PREDICTED: Rattus norvegicus solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 (Slc11a1), transcript variant X1, mRNA","P41251",995,0,"Natural resistance-associated macrophage protein 1","mlr2501",266,{"v":2E-79,"d":"2.00E-79"},"COG1914","pfam01566","Nramp","Natural resistance-associated macrophage protein. The natural resistance-associated macrophage protein (NRAMP) family consists of Nramp1, Nramp2, and yeast proteins Smf1 and Smf2. The NRAMP family is a novel family of functional related proteins defined by a conserved hydrophobic core of ten transmembrane domains. This family of membrane proteins are divalent cation transporters. Nramp1 is an integral membrane protein expressed exclusively in cells of the immune system and is recruited to the membrane of a phagosome upon phagocytosis. By controlling divalent cation concentrations Nramp1 may regulate the interphagosomal replication of bacteria. Mutations in Nramp1 may genetically predispose an individual to susceptibility to diseases including leprosy and tuberculosis conversely this might however provide protection form rheumatoid arthritis. Nramp2 is a multiple divalent cation transporter for Fe2+, Mn2+ and Zn2+ amongst others it is expressed at high levels in the intestine; and is major transferrin-independent iron uptake system in mammals. The yeast proteins Smf1 and Smf2 may also transport divalent cations.","GO:0000165|MAPK cascade;GO:0001818|negative regulation of cytokine production;GO:0001819|positive regulation of cytokine production;GO:0002309|T cell proliferation involved in immune response;GO:0002606|positive regulation of dendritic cell antigen processing and presentation;GO:0002827|positive regulation of T-helper 1 type immune response;GO:0006826|iron ion transport;GO:0006828|manganese ion transport;GO:0006876|cellular cadmium ion homeostasis;GO:0006879|cellular iron ion homeostasis;GO:0006909|phagocytosis;GO:0006954|inflammatory response;GO:0007035|vacuolar acidification;GO:0008150|biological_process;GO:0009617|response to bacterium;GO:0010628|positive regulation of gene expression;GO:0015707|nitrite transport;GO:0030001|metal ion transport;GO:0032147|activation of protein kinase activity;GO:0032496|response to lipopolysaccharide;GO:0032729|positive regulation of interferon-gamma production;GO:0034341|response to interferon-gamma;GO:0034755|iron ion transmembrane transport;GO:0042060|wound healing;GO:0042116|macrophage activation;GO:0042742|defense response to bacterium;GO:0042832|defense response to protozoan;GO:0045342|MHC class II biosynthetic process;GO:0045730|respiratory burst;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048002|antigen processing and presentation of peptide antigen;GO:0048255|mRNA stabilization;GO:0050766|positive regulation of phagocytosis;GO:0050829|defense response to Gram-negative bacterium;GO:0055072|iron ion homeostasis;GO:0060586|multicellular organismal iron ion homeostasis;GO:0070574|cadmium ion transmembrane transport;GO:0070839|divalent metal ion export;GO:0071421|manganese ion transmembrane transport;GO:1902023|L-arginine transport;","GO:0005575|cellular_component;GO:0005764|lysosome;GO:0005770|late endosome;GO:0005886|plasma membrane;GO:0010008|endosome membrane;GO:0016021|integral component of membrane;GO:0030670|phagocytic vesicle membrane;GO:0070821|tertiary granule membrane;","GO:0003674|molecular_function;GO:0005381|iron ion transmembrane transporter activity;GO:0005384|manganese ion transmembrane transporter activity;GO:0015086|cadmium ion transmembrane transporter activity;GO:0042803|protein homodimerization activity;GO:0046873|metal ion transmembrane transporter activity;GO:0046915|transition metal ion transmembrane transporter activity;GO:0051139|metal ion:proton antiporter activity;","K12347","SLC11A1, NRAMP1; natural resistance-associated macrophage protein 1"]
["ENSRNOG00000022242",2150,178.5073201,718,46.18925462,3.864693674,1.950354067,{"v":6.3555e-251,"d":"6.36E-251"},{"v":3.4149e-249,"d":"3.41E-249"},"up","yes","Cxcl9","protein_coding","chr14:15722908-15728435:+","gi|21728396|ref|NP_663705.1|",558,{"v":3e-67,"d":"3.00E-67"},"C-X-C motif chemokine 9 precursor [Rattus norvegicus]","gi|56541235|gb|BC087594.1|",1159,0,"Rattus norvegicus chemokine (C-X-C motif) ligand 9, mRNA (cDNA clone MGC:105312 IMAGE:7310193), complete cds","P18340",166,{"v":2e-48,"d":"2.00E-48"},"C-X-C motif chemokine 9",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0009617|response to bacterium;GO:0030593|neutrophil chemotaxis;GO:0031640|killing of cells of other organism;GO:0042127|regulation of cell proliferation;GO:0045663|positive regulation of myoblast differentiation;GO:0050930|induction of positive chemotaxis;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;GO:0051607|defense response to virus;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098|chemokine-mediated signaling pathway;GO:0071222|cellular response to lipopolysaccharide;GO:1901741|positive regulation of myoblast fusion;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0009897|external side of plasma membrane;","GO:0008009|chemokine activity;GO:0045236|CXCR chemokine receptor binding;GO:0048248|CXCR3 chemokine receptor binding;","K05416","CXCL9; C-X-C motif chemokine 9"]
["ENSRNOG00000008045",962,79.87164742,54,3.473843662,22.99229764,4.523078738,{"v":1.4232e-247,"d":"1.42E-247"},{"v":7.5836E-246,"d":"7.58E-246"},"up","yes","Slamf9","protein_coding","chr13:84941982-84944748:+","gi|157787012|ref|NP_001099441.1|",1339,0,"SLAM family member 9 precursor [Rattus norvegicus]","gi|157787011|ref|NM_001105971.1|",1111,0,"Rattus norvegicus SLAM family member 9 (Slamf9), mRNA","Q9D780",410,{"v":3e-141,"d":"3.00E-141"},"SLAM family member 9",".",".",".",".","pfam13927","Ig_3","Immunoglobulin domain. This family contains immunoglobulin-like domains.","GO:0002273|plasmacytoid dendritic cell differentiation;GO:0002373|plasmacytoid dendritic cell cytokine production;GO:0002410|plasmacytoid dendritic cell chemotaxis;GO:0042110|T cell activation;GO:0042742|defense response to bacterium;","GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000014079",3571,296.4882047,1805,116.1164409,2.553369724,1.352402453,{"v":1.3528e-246,"d":"1.35E-246"},{"v":7.1489e-245,"d":"7.15E-245"},"up","yes","Stat4","protein_coding","chr9:49419340-49588540:-","gi|58866024|ref|NP_001012226.1|",3624,0,"signal transducer and activator of transcription 4 [Rattus norvegicus]","gi|58866023|ref|NM_001012226.1|",2584,0,"Rattus norvegicus signal transducer and activator of transcription 4 (Stat4), mRNA","P42228",1361,0,"Signal transducer and activator of transcription 4",".",".",".",".","pfam02864","STAT_bind","STAT protein, DNA binding domain. STAT proteins (Signal Transducers and Activators of Transcription) are a family of transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors. This family represents the DNA binding domain of STAT, which has an ig-like fold. STAT proteins also include an SH2 domain pfam00017.","GO:0001937|negative regulation of endothelial cell proliferation;GO:0002230|positive regulation of defense response to virus by host;GO:0006351|transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006468|protein phosphorylation;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006952|defense response;GO:0007259|JAK-STAT cascade;GO:0007584|response to nutrient;GO:0008015|blood circulation;GO:0008150|biological_process;GO:0008283|cell proliferation;GO:0008284|positive regulation of cell proliferation;GO:0009410|response to xenobiotic stimulus;GO:0009612|response to mechanical stimulus;GO:0009617|response to bacterium;GO:0010628|positive regulation of gene expression;GO:0010742|macrophage derived foam cell differentiation;GO:0014070|response to organic cyclic compound;GO:0016525|negative regulation of angiogenesis;GO:0019221|cytokine-mediated signaling pathway;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0032496|response to lipopolysaccharide;GO:0032727|positive regulation of interferon-alpha production;GO:0032869|cellular response to insulin stimulus;GO:0033209|tumor necrosis factor-mediated signaling pathway;GO:0034097|response to cytokine;GO:0034240|negative regulation of macrophage fusion;GO:0034340|response to type I interferon;GO:0035456|response to interferon-beta;GO:0035458|cellular response to interferon-beta;GO:0042127|regulation of cell proliferation;GO:0042542|response to hydrogen peroxide;GO:0043124|negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043330|response to exogenous dsRNA;GO:0043434|response to peptide hormone;GO:0045648|positive regulation of erythrocyte differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046725|negative regulation by virus of viral protein levels in host cell;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0051591|response to cAMP;GO:0051607|defense response to virus;GO:0051770|positive regulation of nitric-oxide synthase biosynthetic process;GO:0060333|interferon-gamma-mediated signaling pathway;GO:0060337|type I interferon signaling pathway;GO:0061326|renal tubule development;GO:0061484|hematopoietic stem cell homeostasis;GO:0070106|interleukin-27-mediated signaling pathway;GO:0071222|cellular response to lipopolysaccharide;GO:0071310|cellular response to organic substance;GO:0071345|cellular response to cytokine stimulus;GO:0071346|cellular response to interferon-gamma;GO:0071407|cellular response to organic cyclic compound;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0030424|axon;GO:0030425|dendrite;GO:0032991|protein-containing complex;GO:0048471|perinuclear region of cytoplasm;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000979|RNA polymerase II core promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001222|transcription corepressor binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003690|double-stranded DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0005164|tumor necrosis factor receptor binding;GO:0016922|nuclear receptor binding;GO:0019899|enzyme binding;GO:0031730|CCR5 chemokine receptor binding;GO:0035035|histone acetyltransferase binding;GO:0042393|histone binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0043565|sequence-specific DNA binding;GO:0044389|ubiquitin-like protein ligase binding;GO:0051721|protein phosphatase 2A binding;GO:1990841|promoter-specific chromatin binding;","K11220","STAT1; signal transducer and activator of transcription 1K11220; K11222"]
["ENSRNOG00000050697",3477,288.6836986,1735,111.6133103,2.586463012,1.37098056,{"v":3.5737e-245,"d":"3.57E-245"},{"v":1.873e-243,"d":"1.87E-243"},"up","yes","Ctsz","protein_coding","chr3:163224875-163235645:-","gi|149029991|gb|EDL85083.1|",1101,{"v":1E-142,"d":"1.00E-142"},"cathepsin Z, isoform CRA_a [Rattus norvegicus]","gi|60688148|gb|BC091110.1|",965,0,"Rattus norvegicus cathepsin Z, mRNA (cDNA clone MGC:108536 IMAGE:7379777), complete cds","Q9R1T3",426,{"v":1E-141,"d":"1.00E-141"},"Cathepsin Z",".",".",".",".","pfam00112","Peptidase_C1","Papain family cysteine protease.","GO:0006508|proteolysis;GO:0010757|negative regulation of plasminogen activation;GO:0010977|negative regulation of neuron projection development;GO:0032091|negative regulation of protein binding;GO:0043525|positive regulation of neuron apoptotic process;GO:0051603|proteolysis involved in cellular protein catabolic process;GO:0060441|epithelial tube branching involved in lung morphogenesis;GO:1901214|regulation of neuron death;GO:2000179|positive regulation of neural precursor cell proliferation;","GO:0005615|extracellular space;GO:0005764|lysosome;GO:0005783|endoplasmic reticulum;GO:0009986|cell surface;GO:0030426|growth cone;GO:0031410|cytoplasmic vesicle;","GO:0004180|carboxypeptidase activity;GO:0004197|cysteine-type endopeptidase activity;","K08568","CTSZ; cathepsin X [EC:3.4.18.1]"]
["ENSRNOG00000017874",1263,104.8626722,200,12.86608764,8.150315403,3.02685589,{"v":1.6242e-244,"d":"1.62E-244"},{"v":8.4433e-243,"d":"8.44E-243"},"up","yes","Cd53","protein_coding","chr2:194352139-194399657:-","gi|148669936|gb|EDL01883.1|",1016,{"v":4e-132,"d":"4.00E-132"},"CD53 antigen, isoform CRA_a, partial [Mus musculus]","gi|401709945|ref|NM_012523.2|",1699,0,"Rattus norvegicus Cd53 molecule (Cd53), mRNA","P24485",392,{"v":2E-132,"d":"2.00E-132"},"Leukocyte surface antigen CD53",".",".",".",".","pfam00335","Tetraspannin","Tetraspanin family.","GO:0040008|regulation of growth;GO:1901741|positive regulation of myoblast fusion;","GO:0001772|immunological synapse;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005911|cell-cell junction;GO:0009986|cell surface;","GO:0042802|identical protein binding;","K06489","CD53, MOX44, TSPAN25; CD53 antigen"]
["ENSRNOG00000030712",1149,95.39763294,149,9.58523529,9.952560377,3.315067718,{"v":1.7443e-241,"d":"1.74E-241"},{"v":8.8519e-240,"d":"8.85E-240"},"up","yes","RT1-CE1","protein_coding","chr20:3555782-3559486:-","gi|57012398|ref|NP_001008832.1|",1642,0,"RT1 class I, locus CE1 precursor [Rattus norvegicus]","gi|110350025|gb|AC130591.5|",1181,0,"Rattus norvegicus BAC CH230-312A21 () complete sequence","P16391",528,0,"RT1 class I histocompatibility antigen, AA alpha chain",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.","GO:0001916|positive regulation of T cell mediated cytotoxicity;GO:0002476|antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002485|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent;GO:0002486|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0006955|immune response;GO:0010977|negative regulation of neuron projection development;","GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0045121|membrane raft;","GO:0005102|signaling receptor binding;GO:0005515|protein binding;GO:0042605|peptide antigen binding;","K06751","MHC1; MHC class I antigen"]
["ENSRNOG00000010906",1015,84.27206043,89,5.725408998,14.71895902,3.879603737,{"v":2.9671e-240,"d":"2.97E-240"},{"v":1.4939e-238,"d":"1.49E-238"},"up","yes","Ccl5","protein_coding","chr10:68322829-68327377:-","gi|61889094|ref|NP_112378.2|",337,{"v":3e-35,"d":"3.00E-35"},"C-C motif chemokine 5 precursor [Rattus norvegicus]","gi|354800115|gb|JN964616.1|",465,0,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Ccl5:tm1a(EUCOMM)Hmgu; transgenic","P50231",130,{"v":2E-35,"d":"2.00E-35"},"C-C motif chemokine 5",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0000165|MAPK cascade;GO:0002544|chronic inflammatory response;GO:0002548|monocyte chemotaxis;GO:0006468|protein phosphorylation;GO:0006816|calcium ion transport;GO:0006874|cellular calcium ion homeostasis;GO:0006887|exocytosis;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007159|leukocyte cell-cell adhesion;GO:0007165|signal transduction;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007267|cell-cell signaling;GO:0007568|aging;GO:0009410|response to xenobiotic stimulus;GO:0009615|response to virus;GO:0009617|response to bacterium;GO:0009636|response to toxic substance;GO:0009651|response to salt stress;GO:0010628|positive regulation of gene expression;GO:0010759|positive regulation of macrophage chemotaxis;GO:0010820|positive regulation of T cell chemotaxis;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0014070|response to organic cyclic compound;GO:0014823|response to activity;GO:0014911|positive regulation of smooth muscle cell migration;GO:0018894|dibenzo-p-dioxin metabolic process;GO:0030335|positive regulation of cell migration;GO:0030593|neutrophil chemotaxis;GO:0031269|pseudopodium assembly;GO:0031328|positive regulation of cellular biosynthetic process;GO:0031584|activation of phospholipase D activity;GO:0031622|positive regulation of fever generation;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0031667|response to nutrient levels;GO:0032496|response to lipopolysaccharide;GO:0032868|response to insulin;GO:0033634|positive regulation of cell-cell adhesion mediated by integrin;GO:0034097|response to cytokine;GO:0034112|positive regulation of homotypic cell-cell adhesion;GO:0034341|response to interferon-gamma;GO:0034612|response to tumor necrosis factor;GO:0035688|T-helper 1 cell diapedesis;GO:0042102|positive regulation of T cell proliferation;GO:0042119|neutrophil activation;GO:0042327|positive regulation of phosphorylation;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0043491|protein kinase B signaling;GO:0043547|positive regulation of GTPase activity;GO:0043627|response to estrogen;GO:0043922|negative regulation by host of viral transcription;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0045071|negative regulation of viral genome replication;GO:0045666|positive regulation of neuron differentiation;GO:0045672|positive regulation of osteoclast differentiation;GO:0045744|negative regulation of G protein-coupled receptor signaling pathway;GO:0045766|positive regulation of angiogenesis;GO:0045785|positive regulation of cell adhesion;GO:0048245|eosinophil chemotaxis;GO:0048247|lymphocyte chemotaxis;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0050679|positive regulation of epithelial cell proliferation;GO:0050796|regulation of insulin secretion;GO:0050863|regulation of T cell activation;GO:0050918|positive chemotaxis;GO:0051384|response to glucocorticoid;GO:0051928|positive regulation of calcium ion transport;GO:0060326|cell chemotaxis;GO:0060548|negative regulation of cell death;GO:0060754|positive regulation of mast cell chemotaxis;GO:0061098|positive regulation of protein tyrosine kinase activity;GO:0070098|chemokine-mediated signaling pathway;GO:0070100|negative regulation of chemokine-mediated signaling pathway;GO:0070233|negative regulation of T cell apoptotic process;GO:0070234|positive regulation of T cell apoptotic process;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070723|response to cholesterol;GO:0071222|cellular response to lipopolysaccharide;GO:0071230|cellular response to amino acid stimulus;GO:0071307|cellular response to vitamin K;GO:0071315|cellular response to morphine;GO:0071345|cellular response to cytokine stimulus;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071361|cellular response to ethanol;GO:0071396|cellular response to lipid;GO:0071403|cellular response to high density lipoprotein particle stimulus;GO:0071407|cellular response to organic cyclic compound;GO:0071448|cellular response to alkyl hydroperoxide;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0090026|positive regulation of monocyte chemotaxis;GO:0097305|response to alcohol;GO:0098586|cellular response to virus;GO:1901214|regulation of neuron death;GO:1901215|negative regulation of neuron death;GO:2000110|negative regulation of macrophage apoptotic process;GO:2000406|positive regulation of T cell migration;GO:2000503|positive regulation of natural killer cell chemotaxis;","GO:0005615|extracellular space;GO:0005737|cytoplasm;","GO:0004435|phosphatidylinositol phospholipase C activity;GO:0004672|protein kinase activity;GO:0008009|chemokine activity;GO:0008201|heparin binding;GO:0016004|phospholipase activator activity;GO:0030298|receptor signaling protein tyrosine kinase activator activity;GO:0031726|CCR1 chemokine receptor binding;GO:0031730|CCR5 chemokine receptor binding;GO:0042056|chemoattractant activity;GO:0042379|chemokine receptor binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0043621|protein self-association;GO:0046817|chemokine receptor antagonist activity;GO:0048020|CCR chemokine receptor binding;","K12499","CCL5; C-C motif chemokine 5"]
["ENSRNOG00000063679",1322,109.7612452,240,15.43930516,7.10920887,2.829689022,{"v":1.5195e-239,"d":"1.52E-239"},{"v":7.5315e-238,"d":"7.53E-238"},"up","yes","ENSRNOG00000063679","protein_coding","chr4:31361669-31376415:-","gi|672018010|ref|XP_008773891.1|",8341,0,"PREDICTED: LOW QUALITY PROTEIN: sterile alpha motif domain-containing protein 9-like isoform X1 [Rattus norvegicus]","gi|672018009|ref|XM_008775669.1|",5182,0,"PREDICTED: Rattus norvegicus sterile alpha motif domain-containing protein 9-like (LOC103690031), transcript variant X1, mRNA","Q69Z37",2834,0,"Sterile alpha motif domain-containing protein 9-like",".",".",".",".","pfam09235","Ste50p-SAM","Ste50p, sterile alpha motif. The fungal Ste50p SAM domain consists of five helices, which form a compact, globular fold. It is required for mediation of homodimerization and heterodimerization (and in some cases oligomerization) of the protein.",".",".",".",".","."]
["ENSRNOG00000037198",888,73.72767455,32,2.058574022,35.81492517,5.162489023,{"v":1.3047E-238,"d":"1.30E-238"},{"v":6.4172e-237,"d":"6.42E-237"},"up","yes","Usp18","protein_coding","chr4:154471592-154499144:+","gi|62078849|ref|NP_001014080.1|",1960,0,"ubl carboxyl-terminal hydrolase 18 [Rattus norvegicus]","gi|62078848|ref|NM_001014058.1|",1590,0,"Rattus norvegicus ubiquitin specific peptidase 18 (Usp18), mRNA","Q9WTV6",658,0,"Ubl carboxyl-terminal hydrolase 18","SPBC713.02c",114,{"v":2e-25,"d":"2.00E-25"},"COG5077","pfam00443","UCH","Ubiquitin carboxyl-terminal hydrolase.","GO:0006511|ubiquitin-dependent protein catabolic process;GO:0009617|response to bacterium;GO:0016579|protein deubiquitination;GO:0035634|response to stilbenoid;GO:0050727|regulation of inflammatory response;GO:0060339|negative regulation of type I interferon-mediated signaling pathway;","GO:0005634|nucleus;GO:0005829|cytosol;GO:0043231|intracellular membrane-bounded organelle;","GO:0004197|cysteine-type endopeptidase activity;GO:0004843|thiol-dependent ubiquitin-specific protease activity;GO:0019785|ISG15-specific protease activity;","K11846","USP18_41; ubiquitin carboxyl-terminal hydrolase 18/41 [EC:3.4.19.12]"]
["ENSRNOG00000001153",2081,172.7784806,717,46.12492418,3.745881075,1.905305097,{"v":1.4712e-235,"d":"1.47E-235"},{"v":7.0731E-234,"d":"7.07E-234"},"up","yes","Pla2g1b","protein_coding","chr12:41142200-41153226:-","gi|672072943|ref|XP_008767444.1|",629,{"v":2E-78,"d":"2.00E-78"},"PREDICTED: phospholipase A2 isoform X1 [Rattus norvegicus]","gi|672072942|ref|XM_008769222.1|",650,0,"PREDICTED: Rattus norvegicus phospholipase A2, group IB, pancreas (Pla2g1b), transcript variant X1, mRNA","P04055",244,{"v":6E-79,"d":"6.00E-79"},"Phospholipase A2",".",".",".",".","pfam00068","Phospholip_A2_1","Phospholipase A2. Phospholipase A2 releases fatty acids from the second carbon group of glycerol. Perhaps the best known members are secreted snake venoms, but also found in secreted pancreatic and membrane-associated forms. Structure is all-alpha, with two core disulfide-linked helices and a calcium-binding loop. This alignment represents the major family of PLA2s. A second minor family, defined by the honeybee venom PLA2 PDB:1POC and related sequences from Gila monsters (Heloderma), is not recognized. This minor family conserves the core helix pair but is substantially different elsewhere. The PROSITE pattern PA2_HIS, specific to the first core helix, recognizes both families.","GO:0002227|innate immune response in mucosa;GO:0002446|neutrophil mediated immunity;GO:0006633|fatty acid biosynthetic process;GO:0006644|phospholipid metabolic process;GO:0008284|positive regulation of cell proliferation;GO:0010524|positive regulation of calcium ion transport into cytosol;GO:0016042|lipid catabolic process;GO:0019370|leukotriene biosynthetic process;GO:0019731|antibacterial humoral response;GO:0030593|neutrophil chemotaxis;GO:0032757|positive regulation of interleukin-8 production;GO:0032869|cellular response to insulin stimulus;GO:0035556|intracellular signal transduction;GO:0043406|positive regulation of MAP kinase activity;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046324|regulation of glucose import;GO:0046470|phosphatidylcholine metabolic process;GO:0046471|phosphatidylglycerol metabolic process;GO:0048146|positive regulation of fibroblast proliferation;GO:0050482|arachidonic acid secretion;GO:0050778|positive regulation of immune response;GO:0050830|defense response to Gram-positive bacterium;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:1904635|positive regulation of glomerular visceral epithelial cell apoptotic process;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0009986|cell surface;GO:0030141|secretory granule;","GO:0004623|phospholipase A2 activity;GO:0005102|signaling receptor binding;GO:0005509|calcium ion binding;GO:0032052|bile acid binding;GO:0047498|calcium-dependent phospholipase A2 activity;","K01047","PLA2G, SPLA2; secretory phospholipase A2 [EC:3.1.1.4]"]
["ENSRNOG00000045560",951,78.95835416,68,4.374469797,18.04981125,4.173911846,{"v":2.4862e-235,"d":"2.49E-235"},{"v":1.1863e-233,"d":"1.19E-233"},"up","yes","Gvin1","protein_coding","chr1:160277126-160306331:-","gi|109462622|ref|XP_001075550.1|",12947,0,"PREDICTED: interferon-induced very large GTPase 1-like isoform X1 [Rattus norvegicus]","gi|672014119|ref|XM_001075550.3|",7833,0,"PREDICTED: Rattus norvegicus similar to very large inducible GTPase 1 isoform A (LOC499229), transcript variant X1, mRNA","Q80SU7",4170,0,"Interferon-induced very large GTPase 1",".",".",".",".","pfam05879","RHD3","Root hair defective 3 GTP-binding protein (RHD3). This family consists of several eukaryotic root hair defective 3 like GTP-binding proteins. It has been speculated that the RHD3 protein is a member of a novel class of GTP-binding proteins that is widespread in eukaryotes and required for regulated cell enlargement. The family also contains the homologous yeast synthetic enhancement of YOP1 (SEY1) protein which is involved in membrane trafficking.",".","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0005525|GTP binding;",".","."]
["ENSRNOG00000007350",1102,91.4953799,146,9.392243975,9.741588926,3.284157106,{"v":7.3699E-230,"d":"7.37E-230"},{"v":3.465E-228,"d":"3.47E-228"},"up","yes","Rac2","protein_coding","chr7:110116260-110128720:-","gi|537235276|gb|ERE85167.1|",846,{"v":9e-107,"d":"9.00E-107"},"ras-related C3 botulinum toxin substrate 1-like protein [Cricetulus griseus]","gi|672060205|ref|XM_006242028.2|",587,0,"PREDICTED: Rattus norvegicus ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) (Rac2), transcript variant X1, mRNA","Q05144",311,{"v":3e-101,"d":"3.00E-101"},"Ras-related C3 botulinum toxin substrate 2",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0006935|chemotaxis;GO:0007015|actin filament organization;GO:0007163|establishment or maintenance of cell polarity;GO:0007186|G protein-coupled receptor signaling pathway;GO:0008045|motor neuron axon guidance;GO:0008284|positive regulation of cell proliferation;GO:0008360|regulation of cell shape;GO:0010592|positive regulation of lamellipodium assembly;GO:0010810|regulation of cell-substrate adhesion;GO:0016601|Rac protein signal transduction;GO:0030031|cell projection assembly;GO:0030036|actin cytoskeleton organization;GO:0030865|cortical cytoskeleton organization;GO:0032956|regulation of actin cytoskeleton organization;GO:0042129|regulation of T cell proliferation;GO:0043304|regulation of mast cell degranulation;GO:0043652|engulfment of apoptotic cell;GO:0045453|bone resorption;GO:0050790|regulation of catalytic activity;GO:0060263|regulation of respiratory burst;GO:0060753|regulation of mast cell chemotaxis;GO:0071593|lymphocyte aggregation;GO:0090023|positive regulation of neutrophil chemotaxis;GO:1902622|regulation of neutrophil migration;GO:1903955|positive regulation of protein targeting to mitochondrion;","GO:0005635|nuclear envelope;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0005938|cell cortex;GO:0016020|membrane;GO:0030027|lamellipodium;GO:0031410|cytoplasmic vesicle;GO:0042995|cell projection;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0019887|protein kinase regulator activity;GO:0019901|protein kinase binding;","K07860","RAC2; Ras-related C3 botulinum toxin substrate 2"]
["ENSRNOG00000043451",3409,283.0378857,1754,112.8355886,2.508409707,1.326773008,{"v":9.5714e-229,"d":"9.57E-229"},{"v":4.4348e-227,"d":"4.43E-227"},"up","yes","Spp1","protein_coding","chr14:5308885-5315162:-","gi|145046230|ref|NP_037013.2|",1391,0,"osteopontin precursor [Rattus norvegicus]","gi|298910168|emb|FQ222192.1|",1489,0,"Rattus norvegicus TL0ADA27YG14 mRNA sequence","P08721",521,0,"Osteopontin",".",".",".",".","pfam00865","Osteopontin","Osteopontin.","GO:0001649|osteoblast differentiation;GO:0006710|androgen catabolic process;GO:0006874|cellular calcium ion homeostasis;GO:0006883|cellular sodium ion homeostasis;GO:0006954|inflammatory response;GO:0007155|cell adhesion;GO:0007165|signal transduction;GO:0010033|response to organic substance;GO:0010811|positive regulation of cell-substrate adhesion;GO:0030154|cell differentiation;GO:0030593|neutrophil chemotaxis;GO:0030643|cellular phosphate ion homeostasis;GO:0030644|cellular chloride ion homeostasis;GO:0031214|biomineral tissue development;GO:0033280|response to vitamin D;GO:0034418|urate biosynthetic process;GO:0045780|positive regulation of bone resorption;GO:0045893|positive regulation of transcription, DNA-templated;GO:0048545|response to steroid hormone;GO:0048685|negative regulation of collateral sprouting of intact axon in response to injury;GO:0071394|cellular response to testosterone stimulus;GO:0071498|cellular response to fluid shear stress;GO:0072044|collecting duct development;GO:1990830|cellular response to leukemia inhibitory factor;GO:2000866|positive regulation of estradiol secretion;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0031982|vesicle;GO:0042995|cell projection;GO:0045177|apical part of cell;GO:0048471|perinuclear region of cytoplasm;","GO:0005125|cytokine activity;GO:0005178|integrin binding;GO:0050840|extracellular matrix binding;","K06250","SPP1, BNSP, OPN; secreted phosphoprotein 1"]
["ENSRNOG00000047606",900,74.72399447,56,3.602504538,20.74223465,4.374499425,{"v":2.8879e-228,"d":"2.89E-228"},{"v":1.3284E-226,"d":"1.33E-226"},"up","yes","Bcl2a1","protein_coding","chr8:89716914-89724998:+","gi|149018936|gb|EDL77577.1|",933,{"v":2E-125,"d":"2.00E-125"},"B-cell leukemia/lymphoma 2 related protein A1 [Rattus norvegicus]","gi|19173783|ref|NM_133416.1|",696,0,"Rattus norvegicus BCL2-related protein A1 (Bcl2a1), mRNA","Q07440",325,{"v":5e-112,"d":"5.00E-112"},"Bcl-2-related protein A1",".",".",".",".","pfam00452","Bcl-2","Apoptosis regulator proteins, Bcl-2 family.","GO:0006915|apoptotic process;GO:0007568|aging;GO:0008630|intrinsic apoptotic signaling pathway in response to DNA damage;GO:0021987|cerebral cortex development;GO:0043066|negative regulation of apoptotic process;GO:0097192|extrinsic apoptotic signaling pathway in absence of ligand;","GO:0005575|cellular_component;GO:0005741|mitochondrial outer membrane;","GO:0042803|protein homodimerization activity;GO:0044877|protein-containing complex binding;GO:0046982|protein heterodimerization activity;GO:0051400|BH domain binding;","K02162","BCL2A1; hematopoietic Bcl-2-related protein A1"]
["ENSRNOG00000007234",4248,352.6972539,2472,159.0248432,2.217875187,1.149178179,{"v":1.925e-227,"d":"1.93E-227"},{"v":8.7921e-226,"d":"8.79E-226"},"up","yes","Cyp51","protein_coding","chr4:30036865-30055410:+","gi|6978751|ref|NP_037073.1|",2475,0,"lanosterol 14-alpha demethylase [Rattus norvegicus]","gi|56799391|ref|NM_012941.2|",3013,0,"Rattus norvegicus cytochrome P450, family 51 (Cyp51), mRNA","Q64654",957,0,"Lanosterol 14-alpha demethylase","SPAC13A11.02c",312,{"v":9e-94,"d":"9.00E-94"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0006694|steroid biosynthetic process;GO:0007283|spermatogenesis;GO:0010288|response to lead ion;GO:0016125|sterol metabolic process;GO:0032868|response to insulin;GO:0033488|cholesterol biosynthetic process via 24,25-dihydrolanosterol;GO:0042177|negative regulation of protein catabolic process;GO:0044752|response to human chorionic gonadotropin;GO:0045540|regulation of cholesterol biosynthetic process;GO:0050709|negative regulation of protein secretion;GO:0060282|positive regulation of oocyte development;GO:0070988|demethylation;GO:1900222|negative regulation of amyloid-beta clearance;","GO:0001669|acrosomal vesicle;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0004497|monooxygenase activity;GO:0005506|iron ion binding;GO:0008398|sterol 14-demethylase activity;GO:0016491|oxidoreductase activity;GO:0020037|heme binding;","K05917","CYP51; sterol 14alpha-demethylase [EC:1.14.14.154 1.14.15.36]"]
["ENSRNOG00000006767",839,69.65936818,38,2.444556651,28.49570623,4.832672643,{"v":1.237E-221,"d":"1.24E-221"},{"v":5.3807e-220,"d":"5.38E-220"},"up","yes","Cst7","protein_coding","chr3:139396850-139405557:+","gi|157820635|ref|NP_001099993.1|",711,{"v":6e-90,"d":"6.00E-90"},"cystatin-F precursor [Rattus norvegicus]","gi|157820634|ref|NM_001106523.1|",1140,0,"Rattus norvegicus cystatin F (Cst7), mRNA","O89098",244,{"v":2E-78,"d":"2.00E-78"},"Cystatin-F",".",".",".",".","pfam00031","Cystatin","Cystatin domain. Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 are related to this family but have not been included.","GO:0006955|immune response;GO:0010466|negative regulation of peptidase activity;GO:0031643|positive regulation of myelination;GO:0097340|inhibition of cysteine-type endopeptidase activity;GO:1903979|negative regulation of microglial cell activation;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0005768|endosome;GO:0005770|late endosome;GO:0005771|multivesicular body;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0031410|cytoplasmic vesicle;","GO:0004869|cysteine-type endopeptidase inhibitor activity;GO:0030414|peptidase inhibitor activity;GO:0042803|protein homodimerization activity;","K13903","CST7; cystatin-F"]
["ENSRNOG00000036604",1148,95.31460628,187,12.02979194,7.923213199,2.986085623,{"v":1.337E-219,"d":"1.34E-219"},{"v":5.7764e-218,"d":"5.78E-218"},"up","yes","Ifit2","protein_coding","chr1:232102570-232108635:+","gi|67078506|ref|NP_001019924.1|",2343,0,"interferon-induced protein with tetratricopeptide repeats 2 [Rattus norvegicus]","gi|67078505|ref|NM_001024753.1|",3402,0,"Rattus norvegicus interferon-induced protein with tetratricopeptide repeats 2 (Ifit2), mRNA","Q64112",713,0,"Interferon-induced protein with tetratricopeptide repeats 2",".",".",".",".","pfam13424","TPR_12","Tetratricopeptide repeat.","GO:0009615|response to virus;GO:0032091|negative regulation of protein binding;GO:0035457|cellular response to interferon-alpha;GO:0043065|positive regulation of apoptotic process;GO:0051607|defense response to virus;","GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;","GO:0003723|RNA binding;","K24848","IFIT2; interferon-induced protein with tetratricopeptide repeats 2"]
["ENSRNOG00000069480",1976,164.0606812,708,45.54595023,3.602091522,1.848834838,{"v":5.8472e-215,"d":"5.85E-215"},{"v":2.4436e-213,"d":"2.44E-213"},"up","yes","ENSRNOG00000069480","protein_coding","chr20:3310825-3421372:-","gi|3493249|gb|AAC33332.1|",1284,{"v":3e-159,"d":"3.00E-159"},"MHC class I antigen [Rattus norvegicus]","gi|46237620|emb|BX883046.1|",1780,0,"Rattus norvegicus chromosome 20, major histocompatibility complex, assembled from 40 BACs, strain Brown Norway (BN/ssNHsd), RT1n haplotype; segment 5/11","P16391",465,{"v":6E-148,"d":"6.00E-148"},"RT1 class I histocompatibility antigen, AA alpha chain",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.",".",".",".",".","."]
["ENSRNOG00000024899",889,73.81070121,74,4.760452426,15.50497613,3.954659399,{"v":2.8285e-213,"d":"2.83E-213"},{"v":1.1668E-211,"d":"1.17E-211"},"up","yes","Cxcl13","protein_coding","chr14:13608902-13613933:-","gi|564383008|ref|XP_006250772.1|",486,{"v":5e-57,"d":"5.00E-57"},"PREDICTED: C-X-C motif chemokine 13 isoform X1 [Rattus norvegicus]","gi|672075817|ref|XM_006250710.2|",1087,0,"PREDICTED: Rattus norvegicus chemokine (C-X-C motif) ligand 13 (Cxcl13), transcript variant X1, mRNA","O55038",139,{"v":2e-38,"d":"2.00E-38"},"C-X-C motif chemokine 13",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0002518|lymphocyte chemotaxis across high endothelial venule;GO:0006954|inflammatory response;GO:0007166|cell surface receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007267|cell-cell signaling;GO:0010820|positive regulation of T cell chemotaxis;GO:0030593|neutrophil chemotaxis;GO:0031640|killing of cells of other organism;GO:0033625|positive regulation of integrin activation;GO:0033634|positive regulation of cell-cell adhesion mediated by integrin;GO:0035754|B cell chemotaxis;GO:0035768|endothelial cell chemotaxis to fibroblast growth factor;GO:0035769|B cell chemotaxis across high endothelial venule;GO:0042742|defense response to bacterium;GO:0048535|lymph node development;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098|chemokine-mediated signaling pathway;GO:0071222|cellular response to lipopolysaccharide;GO:0090630|activation of GTPase activity;GO:2000545|negative regulation of endothelial cell chemotaxis to fibroblast growth factor;","GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0008009|chemokine activity;GO:0008201|heparin binding;GO:0017134|fibroblast growth factor binding;GO:0031724|CXCR5 chemokine receptor binding;GO:0031735|CCR10 chemokine receptor binding;GO:0045236|CXCR chemokine receptor binding;GO:0048018|receptor ligand activity;GO:0048248|CXCR3 chemokine receptor binding;","K10032","CXCL13; C-X-C motif chemokine 13"]
["ENSRNOG00000020845",1601,132.9256835,469,30.17097551,4.405746956,2.139386636,{"v":6.6548e-211,"d":"6.65E-211"},{"v":2.7277e-209,"d":"2.73E-209"},"up","yes","Tyrobp","protein_coding","chr1:85672994-85676848:+","gi|47058976|ref|NP_997690.1|",594,{"v":7e-76,"d":"7.00E-76"},"TYRO protein tyrosine kinase-binding protein precursor [Rattus norvegicus]","gi|298889183|emb|FQ211365.1|",529,0,"Rattus norvegicus TL0ABA12YD08 mRNA sequence","Q6X9T7",233,{"v":2e-77,"d":"2.00E-77"},"TYRO protein tyrosine kinase-binding protein",".",".",".",".","pfam07213","DAP10","DAP10 membrane protein. This family consists of several mammalian DAP10 membrane proteins. In activated mouse natural killer (NK) cells, the NKG2D receptor associates with two intracellular adaptors, DAP10 and DAP12, which trigger phosphatidyl inositol 3 kinase (PI3K) and Syk family protein tyrosine kinases, respectively. It has been suggested that the DAP10-PI3K pathway is sufficient to initiate NKG2D-mediated killing of target cells.","GO:0002222|stimulatory killer cell immunoglobulin-like receptor signaling pathway;GO:0002223|stimulatory C-type lectin receptor signaling pathway;GO:0002274|myeloid leukocyte activation;GO:0002281|macrophage activation involved in immune response;GO:0002282|microglial cell activation involved in immune response;GO:0002283|neutrophil activation involved in immune response;GO:0007229|integrin-mediated signaling pathway;GO:0010628|positive regulation of gene expression;GO:0030036|actin cytoskeleton organization;GO:0030316|osteoclast differentiation;GO:0030889|negative regulation of B cell proliferation;GO:0030900|forebrain development;GO:0032693|negative regulation of interleukin-10 production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032755|positive regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032816|positive regulation of natural killer cell activation;GO:0032911|negative regulation of transforming growth factor beta1 production;GO:0032930|positive regulation of superoxide anion generation;GO:0034241|positive regulation of macrophage fusion;GO:0043277|apoptotic cell clearance;GO:0048678|response to axon injury;GO:0050821|protein stabilization;GO:0097190|apoptotic signaling pathway;GO:0110090|positive regulation of hippocampal neuron apoptotic process;GO:1900272|negative regulation of long-term synaptic potentiation;GO:1901216|positive regulation of neuron death;GO:1902685|positive regulation of receptor localization to synapse;GO:1904151|positive regulation of microglial cell mediated cytotoxicity;GO:2000010|positive regulation of protein localization to cell surface;GO:2001204|regulation of osteoclast development;GO:2001206|positive regulation of osteoclast development;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;","GO:0005102|signaling receptor binding;GO:0005515|protein binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0046872|metal ion binding;","K07992","TYROBP, DAP12; TYRO protein tyrosine kinase binding protein"]
["ENSRNOG00000001005",827,68.66304825,51,3.280852347,20.92841767,4.387391333,{"v":3.2362E-210,"d":"3.24E-210"},{"v":1.318e-208,"d":"1.32E-208"},"up","yes","Fcer2","protein_coding","chr12:1742815-1754476:-","gi|76781460|ref|NP_001029096.1|",1572,0,"low affinity immunoglobulin epsilon Fc receptor isoform a [Rattus norvegicus]","gi|76781459|ref|NM_001033924.1|",1995,0,"Rattus norvegicus Fc fragment of IgE receptor II (Fcer2), transcript variant 1, mRNA","P20693",555,0,"Low affinity immunoglobulin epsilon Fc receptor",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0002925|positive regulation of humoral immune response mediated by circulating immunoglobulin;GO:0051000|positive regulation of nitric-oxide synthase activity;GO:0051712|positive regulation of killing of cells of other organism;GO:0051770|positive regulation of nitric-oxide synthase biosynthetic process;","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0030246|carbohydrate binding;","K06468","FCER2, CD23; low affinity immunoglobulin epsilon Fc receptor"]
["ENSRNOG00000020991",836,69.4102882,63,4.052817606,17.12642782,4.098152365,{"v":5.1915e-205,"d":"5.19E-205"},{"v":2.0877E-203,"d":"2.09E-203"},"up","yes","Ms4a6a","protein_coding","chr1:208401466-208414758:-","gi|672014692|ref|XP_001075502.5|",1073,{"v":2E-137,"d":"2.00E-137"},"PREDICTED: membrane-spanning 4-domains subfamily A member 6D [Rattus norvegicus]","gi|672014691|ref|XM_001075502.5|",2442,0,"PREDICTED: Rattus norvegicus membrane-spanning 4-domains, subfamily A, member 6A (Ms4a6a), mRNA","Q99N07",316,{"v":9e-100,"d":"9.00E-100"},"Membrane-spanning 4-domains subfamily A member 6D",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.",".","GO:0005802|trans-Golgi network;GO:0016021|integral component of membrane;",".","K22191","MS4A5_6_7; membrane-spanning 4-domains subfamily A member 5/6/7"]
["ENSRNOG00000007457",2966,246.2570751,1518,97.65360516,2.521740746,1.334419963,{"v":4.8558e-201,"d":"4.86E-201"},{"v":1.9166e-199,"d":"1.92E-199"},"up","yes","Serping1","protein_coding","chr3:69842739-69852034:-","gi|40018558|ref|NP_954524.1|",2362,0,"plasma protease C1 inhibitor precursor [Rattus norvegicus]","gi|40018557|ref|NM_199093.1|",1783,0,"Rattus norvegicus serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 (Serping1), mRNA","Q6P734",914,0,"Plasma protease C1 inhibitor","MA3388",91.3,{"v":7e-19,"d":"7.00E-19"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0001869|negative regulation of complement activation, lectin pathway;GO:0006958|complement activation, classical pathway;GO:0007568|aging;GO:0007596|blood coagulation;GO:0010951|negative regulation of endopeptidase activity;GO:0042730|fibrinolysis;GO:0045087|innate immune response;","GO:0005615|extracellular space;","GO:0001848|complement binding;GO:0003674|molecular_function;GO:0004867|serine-type endopeptidase inhibitor activity;","K04001","SERPING1, C1INH; C1 inhibitor"]
["ENSRNOG00000005809",1224,101.6246325,274,17.62654006,5.765432814,2.527428916,{"v":7.425e-197,"d":"7.43E-197"},{"v":2.8949e-195,"d":"2.89E-195"},"up","yes","Arhgdib","protein_coding","chr4:169822952-169841658:-","gi|57527565|ref|NP_001009600.1|",1048,{"v":3e-139,"d":"3.00E-139"},"rho GDP-dissociation inhibitor 2 [Rattus norvegicus]","gi|672051435|ref|XM_006237562.2|",1276,0,"PREDICTED: Rattus norvegicus Rho, GDP dissociation inhibitor (GDI) beta (Arhgdib), transcript variant X2, mRNA","Q61599",394,{"v":4e-135,"d":"4.00E-135"},"Rho GDP-dissociation inhibitor 2",".",".",".",".","pfam02115","Rho_GDI","RHO protein GDP dissociation inhibitor.","GO:0007266|Rho protein signal transduction;GO:0035023|regulation of Rho protein signal transduction;GO:0050790|regulation of catalytic activity;GO:0071461|cellular response to redox state;GO:1901164|negative regulation of trophoblast cell migration;GO:2000249|regulation of actin cytoskeleton reorganization;","GO:0005829|cytosol;GO:0016020|membrane;","GO:0003924|GTPase activity;GO:0005094|Rho GDP-dissociation inhibitor activity;GO:0031267|small GTPase binding;","K12462","ARHGDI, RHOGDI; Rho GDP-dissociation inhibitor"]
["ENSRNOG00000024382",818,67.91580831,68,4.374469797,15.52549485,3.956567348,{"v":1.8153E-196,"d":"1.82E-196"},{"v":7.0345e-195,"d":"7.03E-195"},"up","yes","Fcgr3a","protein_coding","chr13:83249872-83259921:+","gi|672074776|ref|XP_008767961.1|",1276,{"v":3e-173,"d":"3.00E-173"},"PREDICTED: Fc fragment of IgG, low affinity IIIa, receptor isoform X1 [Rattus norvegicus]","gi|672074775|ref|XM_008769739.1|",1111,0,"PREDICTED: Rattus norvegicus Fc fragment of IgG, low affinity IIIa, receptor (Fcgr3a), transcript variant X1, mRNA","A0A0B4J1G0",409,{"v":1e-140,"d":"1.00E-140"},"Low affinity immunoglobulin gamma Fc region receptor IV",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0007166|cell surface receptor signaling pathway;GO:0038094|Fc-gamma receptor signaling pathway;GO:0038095|Fc-epsilon receptor signaling pathway;GO:0042060|wound healing;GO:0042119|neutrophil activation;GO:0045780|positive regulation of bone resorption;GO:0050776|regulation of immune response;GO:0051930|regulation of sensory perception of pain;GO:0071222|cellular response to lipopolysaccharide;","GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;","GO:0003674|molecular_function;GO:0004888|transmembrane signaling receptor activity;GO:0019767|IgE receptor activity;GO:0019770|IgG receptor activity;","K06463","FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III"]
["ENSRNOG00000017512",2392,198.599772,1084,69.73419499,2.847953891,1.509925789,{"v":2.1791e-195,"d":"2.18E-195"},{"v":8.3935e-194,"d":"8.39E-194"},"up","yes","Aldh3b1","protein_coding","chr1:201145309-201163921:-","gi|55742838|ref|NP_001006999.1|",2518,0,"aldehyde dehydrogenase family 3 member B1 [Rattus norvegicus]","gi|672039352|ref|XM_008760134.1|",1832,0,"PREDICTED: Rattus norvegicus aldehyde dehydrogenase 3 family, member B1 (Aldh3b1), transcript variant X4, mRNA","Q5XI42",974,0,"Aldehyde dehydrogenase family 3 member B1","alr3672",460,{"v":1e-154,"d":"1.00E-154"},"COG1012","pfam00171","Aldedh","Aldehyde dehydrogenase family. This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:1.2.1.3. Succinate-semialdehyde dehydrogenase EC:1.2.1.16. Lactaldehyde dehydrogenase EC:1.2.1.22. Benzaldehyde dehydrogenase EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase EC: 1.5.1.12. Acetaldehyde dehydrogenase EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase EC:1.2.1.41. This family also includes omega crystallin, an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.","GO:0006068|ethanol catabolic process;GO:0006081|cellular aldehyde metabolic process;GO:0006979|response to oxidative stress;GO:0034599|cellular response to oxidative stress;GO:0046185|aldehyde catabolic process;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0004029|aldehyde dehydrogenase (NAD) activity;GO:0004030|aldehyde dehydrogenase [NAD(P)+] activity;GO:0016620|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor;GO:0018477|benzaldehyde dehydrogenase (NADP+) activity;GO:0018479|benzaldehyde dehydrogenase (NAD+) activity;","K00129","ALDH3; aldehyde dehydrogenase (NAD(P)+) [EC:1.2.1.5]"]
["ENSRNOG00000004009",1746,144.9645493,611,39.30589773,3.688111903,1.88288243,{"v":6.9676e-195,"d":"6.97E-195"},{"v":2.6678E-193,"d":"2.67E-193"},"up","yes","ENSRNOG00000004009","protein_coding","chrX:127287979-127317223:+","gi|16924020|ref|NP_476496.1|",3562,0,"xaa-Pro aminopeptidase 2 precursor [Rattus norvegicus]","gi|49258141|gb|BC074017.1|",3276,0,"Rattus norvegicus X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound, mRNA (cDNA clone MGC:91533 IMAGE:7098467), complete cds","Q99MA2",1376,0,"Xaa-Pro aminopeptidase 2","VC0067",352,{"v":9e-107,"d":"9.00E-107"},"COG0006","pfam00557","Peptidase_M24","Metallopeptidase family M24. This family contains metallopeptidases. It also contains non-peptidase homologues such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.","GO:0006508|proteolysis;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0031225|anchored component of membrane;GO:0070062|extracellular exosome;","GO:0003674|molecular_function;GO:0046872|metal ion binding;GO:0070006|metalloaminopeptidase activity;","K14208","XPNPEP2; Xaa-Pro aminopeptidase 2 [EC:3.4.11.9]"]
["ENSRNOG00000000457",1482,123.0455109,437,28.11240149,4.376912124,2.129913419,{"v":2.6469e-194,"d":"2.65E-194"},{"v":1.0074e-192,"d":"1.01E-192"},"up","yes","Tap1","protein_coding","chr20:4656263-4666901:-","gi|56717|emb|CAA40742.1|",3336,0,"mtp1 [Rattus norvegicus]","gi|74355727|gb|BC101854.1|",2886,0,"Rattus norvegicus transporter 1, ATP-binding cassette, sub-family B (MDR/TAP), mRNA (cDNA clone MGC:124549 IMAGE:7933924), complete cds","P36370",1267,0,"Antigen peptide transporter 1",".",".",".",".","pfam00664","ABC_membrane","ABC transporter transmembrane region. This family represents a unit of six transmembrane helices. Many members of the ABC transporter family (pfam00005) have two such regions.","GO:0002250|adaptive immune response;GO:0002479|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0006952|defense response;GO:0015031|protein transport;GO:0015833|peptide transport;GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0042270|protection from natural killer cell mediated cytotoxicity;GO:0046967|cytosol to ER transport;GO:0046968|peptide antigen transport;GO:0055085|transmembrane transport;","GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;GO:0030176|integral component of endoplasmic reticulum membrane;GO:0034451|centriolar satellite;GO:0042824|MHC class I peptide loading complex;GO:0042825|TAP complex;GO:0043231|intracellular membrane-bounded organelle;","GO:0000166|nucleotide binding;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0015433|peptide antigen-transporting ATPase activity;GO:0015440|peptide-transporting ATPase activity;GO:0016887|ATPase activity;GO:0023029|MHC class Ib protein binding;GO:0042288|MHC class I protein binding;GO:0042605|peptide antigen binding;GO:0042626|ATPase activity, coupled to transmembrane movement of substances;GO:0042803|protein homodimerization activity;GO:0043531|ADP binding;GO:0044877|protein-containing complex binding;GO:0046872|metal ion binding;GO:0046978|TAP1 binding;GO:0046979|TAP2 binding;GO:0046980|tapasin binding;GO:1904680|peptide transmembrane transporter activity;","K05653","ABCB2, TAP1; ATP-binding cassette, subfamily B (MDR/TAP), member 2 [EC:7.4.2.14]"]
["ENSRNOG00000022298",714,59.28103561,13,0.836295696,70.8852573,6.147413702,{"v":9.0276e-194,"d":"9.03E-194"},{"v":3.3757e-192,"d":"3.38E-192"},"up","yes","Cxcl11","protein_coding","chr14:15689424-15692271:+","gi|33636734|ref|NP_891997.1|",527,{"v":4e-63,"d":"4.00E-63"},"C-X-C motif chemokine 11 precursor [Rattus norvegicus]","gi|197246580|gb|BC168725.1|",1123,0,"Rattus norvegicus chemokine (C-X-C motif) ligand 11, mRNA (cDNA clone MGC:188799 IMAGE:6919932), complete cds","Q9JHH5",137,{"v":8e-38,"d":"8.00E-38"},"C-X-C motif chemokine 11",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0010818|T cell chemotaxis;GO:0030593|neutrophil chemotaxis;GO:0031640|killing of cells of other organism;GO:0042127|regulation of cell proliferation;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098|chemokine-mediated signaling pathway;GO:0071222|cellular response to lipopolysaccharide;","GO:0005615|extracellular space;GO:0016021|integral component of membrane;","GO:0008009|chemokine activity;GO:0008201|heparin binding;GO:0042379|chemokine receptor binding;GO:0045236|CXCR chemokine receptor binding;GO:0048248|CXCR3 chemokine receptor binding;","K12672","CXCL11, I-TAC; C-X-C motif chemokine 11"]
["ENSRNOG00000001369",1352,112.252045,359,23.09462731,4.86052637,2.281112559,{"v":5.9394e-193,"d":"5.94E-193"},{"v":2.1952e-191,"d":"2.20E-191"},"up","yes","Oas1a","protein_coding","chr12:35669801-35680517:+","gi|149063436|gb|EDM13759.1|",1750,0,"rCG21913 [Rattus norvegicus]","gi|672072909|ref|XM_006249382.2|",1125,0,"PREDICTED: Rattus norvegicus 2'-5' oligoadenylate synthetase 1A (Oas1a), transcript variant X1, mRNA","Q05961",677,0,"2'-5'-oligoadenylate synthase 1A",".",".",".",".","pfam10421","OAS1_C","2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus. This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between 320 and 344 at the extreme C-terminal end. Oligoadenylate synthetases are antiviral enzymes that counteract vial attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesize 2'.5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication. This domain is often associated with NTP_transf_2 pfam01909.","GO:0006006|glucose metabolic process;GO:0006164|purine nucleotide biosynthetic process;GO:0009615|response to virus;GO:0032728|positive regulation of interferon-beta production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0034138|toll-like receptor 3 signaling pathway;GO:0034142|toll-like receptor 4 signaling pathway;GO:0035457|cellular response to interferon-alpha;GO:0035458|cellular response to interferon-beta;GO:0042593|glucose homeostasis;GO:0042742|defense response to bacterium;GO:0043129|surfactant homeostasis;GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0051259|protein complex oligomerization;GO:0051607|defense response to virus;GO:0060337|type I interferon signaling pathway;GO:0060339|negative regulation of type I interferon-mediated signaling pathway;GO:0060700|regulation of ribonuclease activity;GO:0070106|interleukin-27-mediated signaling pathway;GO:0071639|positive regulation of monocyte chemotactic protein-1 production;GO:0071659|negative regulation of IP-10 production;GO:0098586|cellular response to virus;GO:1901857|positive regulation of cellular respiration;GO:2000342|negative regulation of chemokine (C-X-C motif) ligand 2 production;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;GO:0005840|ribosome;GO:0016020|membrane;","GO:0001730|2'-5'-oligoadenylate synthetase activity;GO:0003725|double-stranded RNA binding;GO:0005524|ATP binding;GO:0046872|metal ion binding;","K14216","OAS; 2'-5'-oligoadenylate synthetase [EC:2.7.7.84]"]
["ENSRNOG00000066242",1289,107.0213654,324,20.84306197,5.134627799,2.360259702,{"v":1.2387E-191,"d":"1.24E-191"},{"v":4.5519E-190,"d":"4.55E-190"},"up","yes","Rtp4","protein_coding","chr11:77238216-77335437:-","gi|157820051|ref|NP_001101791.1|",1050,{"v":4e-139,"d":"4.00E-139"},"receptor-transporting protein 4 [Rattus norvegicus]","gi|672071410|ref|XM_006248521.2|",859,0,"PREDICTED: Rattus norvegicus receptor (chemosensory) transporter protein 4 (Rtp4), transcript variant X1, mRNA","Q9ER80",298,{"v":3e-97,"d":"3.00E-97"},"Receptor-transporting protein 4",".",".",".",".","pfam13695","zf-3CxxC","Zinc-binding domain. This is a family with several pairs of CxxC motifs possibly representing a multiple zinc-binding region. Only one pair of cysteines is associated with a highly conserved histidine residue.",".",".",".",".","."]
["ENSRNOG00000021157",2551,211.801011,1233,79.31943028,2.670228597,1.416963255,{"v":1.3988e-189,"d":"1.40E-189"},{"v":5.1109e-188,"d":"5.11E-188"},"up","yes","Ctss","protein_coding","chr2:183086437-183114483:+","gi|74214026|dbj|BAE29430.1|",1648,0,"unnamed protein product [Mus musculus]","gi|298901396|emb|FQ218804.1|",1393,0,"Rattus norvegicus TL0ABA49YN06 mRNA sequence","O70370",629,0,"Cathepsin S","AF1946_2",91.7,{"v":7e-20,"d":"7.00E-20"},"COG4870","pfam00112","Peptidase_C1","Papain family cysteine protease.","GO:0001656|metanephros development;GO:0002250|adaptive immune response;GO:0006508|proteolysis;GO:0006955|immune response;GO:0010447|response to acidic pH;GO:0016485|protein processing;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030574|collagen catabolic process;GO:0034769|basement membrane disassembly;GO:0045453|bone resorption;GO:0048002|antigen processing and presentation of peptide antigen;GO:0050729|positive regulation of inflammatory response;GO:0051603|proteolysis involved in cellular protein catabolic process;GO:0051930|regulation of sensory perception of pain;GO:0097067|cellular response to thyroid hormone stimulus;GO:2001259|positive regulation of cation channel activity;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005764|lysosome;GO:0005770|late endosome;GO:0009986|cell surface;GO:0016020|membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0045335|phagocytic vesicle;","GO:0001968|fibronectin binding;GO:0004197|cysteine-type endopeptidase activity;GO:0004252|serine-type endopeptidase activity;GO:0005518|collagen binding;GO:0008233|peptidase activity;GO:0008234|cysteine-type peptidase activity;GO:0043236|laminin binding;GO:0043394|proteoglycan binding;","K01368","CTSS; cathepsin S [EC:3.4.22.27]"]
["ENSRNOG00000019050",722,59.9452489,41,2.637547966,22.72764313,4.506376178,{"v":4.9062e-186,"d":"4.91E-186"},{"v":1.7624e-184,"d":"1.76E-184"},"up","yes","ENSRNOG00000019050","protein_coding","chr1:232127170-232154435:+","gi|9910234|ref|NP_064481.1|",2382,0,"interferon-induced protein with tetratricopeptide repeats 1-like protein [Rattus norvegicus]","gi|9910233|ref|NM_020096.1|",1926,0,"Rattus norvegicus interferon-induced protein with tetratricopeptide repeats 1 (Ifit1), mRNA","Q64282",790,0,"Interferon-induced protein with tetratricopeptide repeats 1",".",".",".",".","pfam13414","TPR_11","TPR repeat.","GO:0009615|response to virus;GO:0009617|response to bacterium;GO:0035457|cellular response to interferon-alpha;GO:0035458|cellular response to interferon-beta;GO:0051607|defense response to virus;","GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0003723|RNA binding;","K14217","IFIT1; interferon-induced protein with tetratricopeptide repeats 1"]
["ENSRNOG00000012807",2646,219.6885437,1333,85.7524741,2.561891608,1.357209437,{"v":3.0577E-184,"d":"3.06E-184"},{"v":1.0802E-182,"d":"1.08E-182"},"up","yes","C1qa","protein_coding","chr5:149133636-149136534:-","gi|56606082|ref|NP_001008515.1|",1272,{"v":3e-169,"d":"3.00E-169"},"complement C1q subcomponent subunit A precursor [Rattus norvegicus]","gi|56606081|ref|NM_001008515.1|",975,0,"Rattus norvegicus complement component 1, q subcomponent, A chain (C1qa), mRNA","P31720",494,{"v":1e-170,"d":"1.00E-170"},"Complement C1q subcomponent subunit A",".",".",".",".","pfam00386","C1q","C1q domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.","GO:0001774|microglial cell activation;GO:0006958|complement activation, classical pathway;GO:0007568|aging;GO:0010039|response to iron ion;GO:0016322|neuron remodeling;GO:0045087|innate immune response;GO:0048143|astrocyte activation;GO:0050808|synapse organization;GO:0098883|synapse pruning;GO:0150062|complement-mediated synapse pruning;GO:0150064|vertebrate eye-specific patterning;GO:1901216|positive regulation of neuron death;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005581|collagen trimer;GO:0045202|synapse;GO:0098794|postsynapse;","GO:0003674|molecular_function;","K03986","C1QA; complement C1q subcomponent subunit A"]
["ENSRNOG00000029996",1580,131.1821236,534,34.35245399,3.818711865,1.933086068,{"v":8.3099e-183,"d":"8.31E-183"},{"v":2.9195e-181,"d":"2.92E-181"},"up","yes","AABR07054368.1","protein_coding","chr3:143138640-143140802:-","gi|62896605|dbj|BAD96243.1|",1815,0,"eukaryotic translation elongation factor 1 alpha 1 variant [Homo sapiens]","gi|672047760|ref|XR_591795.1|",1138,0,"PREDICTED: Rattus norvegicus elongation factor 1-alpha 1 pseudogene (LOC103691939), misc_RNA","P62630",702,0,"Elongation factor 1-alpha 1","SPCC794.09c",573,0,"COG5256","pfam03143","GTP_EFTU_D3","Elongation factor Tu C-terminal domain. Elongation factor Tu consists of three structural domains, this is the third domain. This domain adopts a beta barrel structure. This the third domain is involved in binding to both charged tRNA and binding to EF-Ts pfam00889.",".",".",".",".","."]
["ENSRNOG00000000456",2806,232.9728094,1480,95.20904851,2.446960799,1.290990989,{"v":6.3268E-181,"d":"6.33E-181"},{"v":2.1986e-179,"d":"2.20E-179"},"up","yes","Psmb8","protein_coding","chr20:4652159-4655283:-","gi|532035172|ref|XP_005360485.1|",1398,0,"PREDICTED: proteasome subunit beta type-8 [Microtus ochrogaster]","gi|258614011|ref|NM_080767.2|",856,0,"Rattus norvegicus proteasome subunit beta 8 (Psmb8), mRNA","P28064",539,0,"Proteasome subunit beta type-8",".",".",".",".","pfam00227","Proteasome","Proteasome subunit. The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria. The second is call beta-proteobacteria proteasome homologue (BPH).","GO:0010498|proteasomal protein catabolic process;GO:0019882|antigen processing and presentation;GO:0045444|fat cell differentiation;GO:0052548|regulation of endopeptidase activity;","GO:0000502|proteasome complex;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005839|proteasome core complex;GO:0019774|proteasome core complex, beta-subunit complex;GO:1990111|spermatoproteasome complex;","GO:0004175|endopeptidase activity;GO:0004298|threonine-type endopeptidase activity;","K02740","PSMB8, LMP7; 20S proteasome subunit beta 8 [EC:3.4.25.1]"]
["ENSRNOG00000020300",1254,104.1154323,331,21.29337504,4.889569272,2.289707382,{"v":6.3727e-180,"d":"6.37E-180"},{"v":2.2026e-178,"d":"2.20E-178"},"up","yes","Lsp1","protein_coding","chr1:197614687-197648416:+","gi|162287322|ref|NP_001020591.1|",908,{"v":2e-111,"d":"2.00E-111"},"lymphocyte-specific protein 1 [Rattus norvegicus]","gi|33354295|gb|AC098563.6|",1479,0,"Rattus norvegicus 1 BAC CH230-123A15 (Children's Hospital Oakland Research Institute) complete sequence","P19973",295,{"v":2E-90,"d":"2.00E-90"},"Lymphocyte-specific protein 1",".",".",".",".","pfam02029","Caldesmon","Caldesmon.","GO:0006935|chemotaxis;GO:0006952|defense response;GO:0007165|signal transduction;GO:0098761|cellular response to interleukin-7;",".","GO:0003779|actin binding;","K14957","LSP1; lymphocyte-specific protein 1"]
["ENSRNOG00000046699",660,54.79759595,17,1.093617449,50.10673155,5.646932529,{"v":6.483E-180,"d":"6.48E-180"},{"v":2.2287e-178,"d":"2.23E-178"},"up","yes","Slpi","protein_coding","chr3:153082369-153084453:-","gi|149042957|gb|EDL96531.1|",659,{"v":8e-86,"d":"8.00E-86"},"rCG32428, isoform CRA_a [Rattus norvegicus]","gi|23451267|gb|AF421377.1|",444,0,"Rattus norvegicus secretory leukocyte protease inhibitor precursor, mRNA, complete cds","P97430",217,{"v":3e-71,"d":"3.00E-71"},"Antileukoproteinase",".",".",".",".","pfam00095","WAP","WAP-type (Whey Acidic Protein) 'four-disulfide core'.","GO:0006955|immune response;GO:0010951|negative regulation of endopeptidase activity;GO:0019731|antibacterial humoral response;GO:0032091|negative regulation of protein binding;GO:0032496|response to lipopolysaccharide;GO:0035821|modification of morphology or physiology of other organism;GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0050728|negative regulation of inflammatory response;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005794|Golgi apparatus;","GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0003729|mRNA binding;GO:0004866|endopeptidase inhibitor activity;GO:0004867|serine-type endopeptidase inhibitor activity;GO:0019899|enzyme binding;","K23638","SLPI, WFDC4; antileukoproteinase"]
["ENSRNOG00000012681",1049,87.09496689,213,13.70238333,6.356191093,2.668162499,{"v":2.9445e-179,"d":"2.94E-179"},{"v":1.0015e-177,"d":"1.00E-177"},"up","yes","Lgals9","protein_coding","chr10:63907018-63930045:-","gi|149053566|gb|EDM05383.1|",1769,0,"rCG33388, isoform CRA_a [Rattus norvegicus]","gi|2351552|gb|U72741.1|RNU72741",1067,0,"Rattus norvegicus 36 Kd beta-galactoside binding lectin mRNA, complete cds","P97840",682,0,"Galectin-9",".",".",".",".","pfam00337","Gal-bind_lectin","Galactoside-binding lectin. This family contains galactoside binding lectins.   The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).","GO:0001819|positive regulation of cytokine production;GO:0002519|natural killer cell tolerance induction;GO:0006811|ion transport;GO:0006954|inflammatory response;GO:0007565|female pregnancy;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0032496|response to lipopolysaccharide;GO:0032682|negative regulation of chemokine production;GO:0032689|negative regulation of interferon-gamma production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032722|positive regulation of chemokine production;GO:0032729|positive regulation of interferon-gamma production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032732|positive regulation of interleukin-1 production;GO:0032733|positive regulation of interleukin-10 production;GO:0032735|positive regulation of interleukin-12 production;GO:0032736|positive regulation of interleukin-13 production;GO:0032753|positive regulation of interleukin-4 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032815|negative regulation of natural killer cell activation;GO:0032823|regulation of natural killer cell differentiation;GO:0032834|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response;GO:0034138|toll-like receptor 3 signaling pathway;GO:0038066|p38MAPK cascade;GO:0043032|positive regulation of macrophage activation;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043305|negative regulation of mast cell degranulation;GO:0043322|negative regulation of natural killer cell degranulation;GO:0045089|positive regulation of innate immune response;GO:0045185|maintenance of protein location;GO:0045591|positive regulation of regulatory T cell differentiation;GO:0045953|negative regulation of natural killer cell mediated cytotoxicity;GO:0046007|negative regulation of activated T cell proliferation;GO:0046598|positive regulation of viral entry into host cell;GO:0050728|negative regulation of inflammatory response;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051353|positive regulation of oxidoreductase activity;GO:0060135|maternal process involved in female pregnancy;GO:0070241|positive regulation of activated T cell autonomous cell death;GO:0070371|ERK1 and ERK2 cascade;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070555|response to interleukin-1;GO:0071346|cellular response to interferon-gamma;GO:0071636|positive regulation of transforming growth factor beta production;GO:0071639|positive regulation of monocyte chemotactic protein-1 production;GO:0071902|positive regulation of protein serine/threonine kinase activity;GO:0098586|cellular response to virus;GO:1900426|positive regulation of defense response to bacterium;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:2000406|positive regulation of T cell migration;GO:2000510|positive regulation of dendritic cell chemotaxis;GO:2000562|negative regulation of CD4-positive, alpha-beta T cell proliferation;GO:2000563|positive regulation of CD4-positive, alpha-beta T cell proliferation;GO:2000670|positive regulation of dendritic cell apoptotic process;GO:2000679|positive regulation of transcription regulatory region DNA binding;GO:2001190|positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:2001200|positive regulation of dendritic cell differentiation;GO:2001269|positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0005102|signaling receptor binding;GO:0016936|galactoside binding;GO:0019899|enzyme binding;GO:0030246|carbohydrate binding;GO:0043539|protein serine/threonine kinase activator activity;GO:0048030|disaccharide binding;","K10093","LGALS9; galectin-9"]
["ENSRNOG00000013014",1864,154.7616952,755,48.56948083,3.186397972,1.671926467,{"v":1.0977e-176,"d":"1.10E-176"},{"v":3.694E-175,"d":"3.69E-175"},"up","yes","Cyba","protein_coding","chr19:50487597-50495721:-","gi|13162359|ref|NP_077074.1|",819,{"v":9e-108,"d":"9.00E-108"},"cytochrome b-245 light chain [Rattus norvegicus]","gi|13162358|ref|NM_024160.1|",656,0,"Rattus norvegicus cytochrome b-245, alpha polypeptide (Cyba), mRNA","Q62737",320,{"v":3e-109,"d":"3.00E-109"},"Cytochrome b-245 light chain",".",".",".",".","pfam05038","Cytochrom_B558a","Cytochrome Cytochrome b558 alpha-subunit. Cytochrome b-245 light chain (p22-phox) is one of the key electron transfer elements of the NADPH oxidase in phagocytes.","GO:0001666|response to hypoxia;GO:0001938|positive regulation of endothelial cell proliferation;GO:0003106|negative regulation of glomerular filtration by angiotensin;GO:0006801|superoxide metabolic process;GO:0006954|inflammatory response;GO:0009410|response to xenobiotic stimulus;GO:0014823|response to activity;GO:0014895|smooth muscle hypertrophy;GO:0017004|cytochrome complex assembly;GO:0022900|electron transport chain;GO:0030307|positive regulation of cell growth;GO:0031667|response to nutrient levels;GO:0032755|positive regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032930|positive regulation of superoxide anion generation;GO:0033864|positive regulation of NAD(P)H oxidase activity;GO:0034137|positive regulation of toll-like receptor 2 signaling pathway;GO:0042554|superoxide anion generation;GO:0045087|innate immune response;GO:0045730|respiratory burst;GO:0045777|positive regulation of blood pressure;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0050665|hydrogen peroxide biosynthetic process;GO:0050766|positive regulation of phagocytosis;GO:0051279|regulation of release of sequestered calcium ion into cytosol;GO:0070257|positive regulation of mucus secretion;GO:0070555|response to interleukin-1;GO:0071230|cellular response to amino acid stimulus;GO:0071260|cellular response to mechanical stimulus;GO:0071310|cellular response to organic substance;GO:0071333|cellular response to glucose stimulus;GO:0071356|cellular response to tumor necrosis factor;GO:0071407|cellular response to organic cyclic compound;GO:0071480|cellular response to gamma radiation;GO:0072593|reactive oxygen species metabolic process;GO:1900426|positive regulation of defense response to bacterium;GO:1903428|positive regulation of reactive oxygen species biosynthetic process;GO:1904044|response to aldosterone;GO:1904385|cellular response to angiotensin;GO:1904845|cellular response to L-glutamine;GO:2000376|positive regulation of oxygen metabolic process;","GO:0001725|stress fiber;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005794|Golgi apparatus;GO:0005925|focal adhesion;GO:0016324|apical plasma membrane;GO:0030425|dendrite;GO:0043020|NADPH oxidase complex;GO:0043025|neuronal cell body;GO:0097038|perinuclear endoplasmic reticulum;","GO:0005515|protein binding;GO:0009055|electron transfer activity;GO:0016175|superoxide-generating NADPH oxidase activity;GO:0017124|SH3 domain binding;GO:0020037|heme binding;GO:0046872|metal ion binding;GO:0046982|protein heterodimerization activity;","K08009","CYBA, P22PHOX; cytochrome b-245, alpha polypeptide"]
["ENSRNOG00000003486",955,79.2904608,168,10.80751362,7.33660522,2.875112656,{"v":2.0776e-176,"d":"2.08E-176"},{"v":6.9551e-175,"d":"6.96E-175"},"up","yes","Mnda","protein_coding","chr13:86017892-86034201:-","gi|58865634|ref|NP_001012029.1|",1794,0,"myeloid cell nuclear differentiation antigen [Rattus norvegicus]","gi|58865633|ref|NM_001012029.1|",1302,0,"Rattus norvegicus myeloid cell nuclear differentiation antigen (Mnda), mRNA","P0DOV2",427,{"v":5e-140,"d":"5.00E-140"},"Interferon-activable protein 204",".",".",".",".","pfam02760","HIN","HIN-200/IF120x domain. This domain has no know function. It is found in one or two copies per protein, and is found associated with the PAAD/DAPIN domain pfam02758.","GO:0002218|activation of innate immune response;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006974|cellular response to DNA damage stimulus;GO:0009617|response to bacterium;GO:0030889|negative regulation of B cell proliferation;GO:0032731|positive regulation of interleukin-1 beta production;GO:0035457|cellular response to interferon-alpha;GO:0035458|cellular response to interferon-beta;GO:0043065|positive regulation of apoptotic process;GO:0045669|positive regulation of osteoblast differentiation;GO:0048839|inner ear development;GO:0050853|B cell receptor signaling pathway;","GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005829|cytosol;GO:0042405|nuclear inclusion body;GO:0043231|intracellular membrane-bounded organelle;","GO:0003690|double-stranded DNA binding;GO:0003712|transcription coregulator activity;",".","."]
["ENSRNOG00000006314",642,53.30311606,20,1.286608764,41.42915668,5.372574548,{"v":2.7756e-174,"d":"2.78E-174"},{"v":9.148e-173,"d":"9.15E-173"},"up","yes","Zbp1","protein_coding","chr3:161993351-162003870:-","gi|449310782|ref|NP_598248.1|",1880,0,"Z-DNA-binding protein 1 [Rattus norvegicus]","gi|672047961|ref|XM_006235674.2|",1856,0,"PREDICTED: Rattus norvegicus Z-DNA binding protein 1 (Zbp1), transcript variant X1, mRNA","Q8VDA5",727,0,"Z-DNA-binding protein 1",".",".",".",".","pfam12721","RHIM","RIP homotypic interaction motif. RIP proteins are receptor-interacting serine/threonine-protein kinases or cell death proteins. This interacting domain is involved in virus recognition. The RHIM domain is necessary for the recruitment of RIP and RIP3 by the IFN-inducible protein DNA-dependent activator of IRFs (DAI), also known as DLM-1 or Z-DNA binding protein (ZBP1). Both the RIP kinases contribute to DAI-induced NF-kappaB activation. RIP3 undergoes auto phosphorylation on binding to DAI.","GO:0002218|activation of innate immune response;GO:0006915|apoptotic process;GO:0043065|positive regulation of apoptotic process;GO:0045087|innate immune response;GO:0050727|regulation of inflammatory response;GO:0050729|positive regulation of inflammatory response;GO:0051607|defense response to virus;GO:0060340|positive regulation of type I interferon-mediated signaling pathway;GO:0060545|positive regulation of necroptotic process;GO:0070269|pyroptosis;GO:2000659|regulation of interleukin-1-mediated signaling pathway;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0003677|DNA binding;GO:0003692|left-handed Z-DNA binding;GO:0003723|RNA binding;GO:0003725|double-stranded RNA binding;GO:0003726|double-stranded RNA adenosine deaminase activity;GO:0042802|identical protein binding;","K12965","ZBP1, DAI; Z-DNA binding protein 1"]
["ENSRNOG00000008738",2572,213.5445709,1318,84.78751753,2.518585012,1.332613429,{"v":3.016E-174,"d":"3.02E-174"},{"v":9.8897e-173,"d":"9.89E-173"},"up","yes","Tp53i11","protein_coding","chr3:79144895-79160050:+","gi|537145935|gb|ERE69626.1|",1012,{"v":7E-126,"d":"7.00E-126"},"tumor protein inducible protein 11 [Cricetulus griseus]","gi|672046285|ref|XM_006234570.2|",2793,0,"PREDICTED: Rattus norvegicus tumor protein p53 inducible protein 11 (Tp53i11), transcript variant X2, mRNA","Q4QQM4",318,{"v":1E-100,"d":"1.00E-100"},"Tumor protein p53-inducible protein 11",".",".",".",".","pfam14936","p53-inducible11","tumor protein p53-inducible protein 11. TP53 is a tumor suppressor gene, when switched on it suppresses tumor development by inducing stable growth arrest or cell apoptosis. The tumor protein TP53 inducible protein 11 encoded for by the gene TP53I11, has a protein sequence of 189 amino acids in length and 21 kDa in mass. The role of this protein is thought to negatively regulate cell proliferation in response to stress, and therefore suppress tumor formation.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000017703",1998,165.8872677,864,55.58149859,2.984577097,1.577526522,{"v":3.0447e-174,"d":"3.04E-174"},{"v":9.9326e-173,"d":"9.93E-173"},"up","yes","Unc93b1","protein_coding","chr1:201152693-201178338:+","gi|564332335|ref|XP_006230895.1|",2378,0,"PREDICTED: protein unc-93 homolog B1 isoform X1 [Rattus norvegicus]","gi|564332334|ref|XM_006230833.1|",2075,0,"PREDICTED: Rattus norvegicus unc-93 homolog B1 (C. elegans) (Unc93b1), transcript variant X1, mRNA","Q8VCW4",905,0,"Protein unc-93 homolog B1",".",".",".",".","pfam05978","UNC-93","Ion channel regulatory protein UNC-93. This family of proteins is a component of a multi-subunit protein complex which is involved in the coordination of muscle contraction. UNC-93 is most likely an ion channel regulatory protein.","GO:0000902|cell morphogenesis;GO:0002224|toll-like receptor signaling pathway;GO:0006886|intracellular protein transport;GO:0008150|biological_process;GO:0019882|antigen processing and presentation;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0032735|positive regulation of interleukin-12 production;GO:0032755|positive regulation of interleukin-6 production;GO:0034138|toll-like receptor 3 signaling pathway;GO:0034154|toll-like receptor 7 signaling pathway;GO:0034162|toll-like receptor 9 signaling pathway;","GO:0005575|cellular_component;GO:0005764|lysosome;GO:0005768|endosome;GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;GO:0032009|early phagosome;","GO:0003674|molecular_function;GO:0035325|Toll-like receptor binding;",".","."]
["ENSRNOG00000029191",916,76.05242104,152,9.778226604,7.777731497,2.959349431,{"v":3.916e-174,"d":"3.92E-174"},{"v":1.271E-172,"d":"1.27E-172"},"up","yes","ENSRNOG00000029191","protein_coding","chr2:231275640-231297278:+","gi|392339045|ref|XP_003753713.1|",3074,0,"PREDICTED: guanylate-binding protein 4 isoform X1 [Rattus norvegicus]","gi|672016381|ref|XM_003753665.3|",3367,0,"PREDICTED: Rattus norvegicus similar to guanylate binding protein family, member 6 (LOC685067), transcript variant X1, mRNA","Q61107",877,0,"Guanylate-binding protein 4",".",".",".",".","pfam02263","GBP","Guanylate-binding protein, N-terminal domain. Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.","GO:0044406|adhesion of symbiont to host;",".",".","K20899","GBP1_3_4_7; guanylate-binding protein 1/3/4/7"]
["ENSRNOG00000006094",942,78.21111421,171,11.00050493,7.109774934,2.829803891,{"v":2.7031e-171,"d":"2.70E-171"},{"v":8.5563e-170,"d":"8.56E-170"},"up","yes","Cd44","protein_coding","chr3:89157058-89244620:-","gi|149022754|gb|EDL79648.1|",3838,0,"CD44 antigen, isoform CRA_a [Rattus norvegicus]","gi|672046391|ref|XM_008762059.1|",3940,0,"PREDICTED: Rattus norvegicus Cd44 molecule (Cd44), transcript variant X8, mRNA","P15379",1312,0,"CD44 antigen",".",".",".",".","pfam00193","Xlink","Extracellular link domain.","GO:0001558|regulation of cell growth;GO:0001658|branching involved in ureteric bud morphogenesis;GO:0001955|blood vessel maturation;GO:0002246|wound healing involved in inflammatory response;GO:0002906|negative regulation of mature B cell apoptotic process;GO:0006954|inflammatory response;GO:0007155|cell adhesion;GO:0010628|positive regulation of gene expression;GO:0014070|response to organic cyclic compound;GO:0016055|Wnt signaling pathway;GO:0016477|cell migration;GO:0019221|cytokine-mediated signaling pathway;GO:0030214|hyaluronan catabolic process;GO:0031175|neuron projection development;GO:0031667|response to nutrient levels;GO:0033031|positive regulation of neutrophil apoptotic process;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0033189|response to vitamin A;GO:0033674|positive regulation of kinase activity;GO:0034116|positive regulation of heterotypic cell-cell adhesion;GO:0034238|macrophage fusion;GO:0042110|T cell activation;GO:0043066|negative regulation of apoptotic process;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043518|negative regulation of DNA damage response, signal transduction by p53 class mediator;GO:0044319|wound healing, spreading of cells;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0045590|negative regulation of regulatory T cell differentiation;GO:0050728|negative regulation of inflammatory response;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0051216|cartilage development;GO:0060442|branching involved in prostate gland morphogenesis;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070487|monocyte aggregation;GO:1900625|positive regulation of monocyte aggregation;GO:1902166|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:2000392|regulation of lamellipodium morphogenesis;GO:2000562|negative regulation of CD4-positive, alpha-beta T cell proliferation;","GO:0005634|nucleus;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005902|microvillus;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0031258|lamellipodium membrane;GO:0032991|protein-containing complex;GO:0035692|macrophage migration inhibitory factor receptor complex;GO:0042995|cell projection;","GO:0004888|transmembrane signaling receptor activity;GO:0004896|cytokine receptor activity;GO:0005114|type II transforming growth factor beta receptor binding;GO:0005154|epidermal growth factor receptor binding;GO:0005515|protein binding;GO:0005540|hyaluronic acid binding;GO:0019901|protein kinase binding;GO:0019955|cytokine binding;GO:0051219|phosphoprotein binding;","K06256","CD44; CD44 antigen"]
["ENSRNOG00000028668",1386,115.0749515,439,28.24106236,4.074738762,2.026707569,{"v":8.8843e-171,"d":"8.88E-171"},{"v":2.7846E-169,"d":"2.78E-169"},"up","yes","Slc28a2","protein_coding","chr3:109366996-109387702:+","gi|15721849|gb|AAK38150.1|",3322,0,"concentrative Na+ nucleoside cotransporter [Rattus norvegicus]","gi|15721848|gb|AY029302.1|",2617,0,"Rattus norvegicus concentrative Na+ nucleoside cotransporter mRNA, complete cds","Q62773",1282,0,"Sodium/nucleoside cotransporter 2","all0378",345,{"v":2e-108,"d":"2.00E-108"},"COG1972","pfam07662","Nucleos_tra2_C","Na+ dependent nucleoside transporter C-terminus. This family consists of nucleoside transport proteins. Members include a purine-specific Na+-nucleoside cotransporter localized to the bile canalicular membrane and a Na+-dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine, which also transports the anti-viral nucleoside analogues AZT and ddC. This alignment covers the C-terminus of this family of transporters.","GO:0001895|retina homeostasis;GO:0006836|neurotransmitter transport;GO:0015855|pyrimidine nucleobase transport;GO:0015860|purine nucleoside transmembrane transport;GO:0015862|uridine transport;GO:0032238|adenosine transport;GO:0034394|protein localization to cell surface;GO:0035340|inosine transport;GO:0072531|pyrimidine-containing compound transmembrane transport;GO:1901642|nucleoside transmembrane transport;GO:1904823|purine nucleobase transmembrane transport;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0012506|vesicle membrane;GO:0030135|coated vesicle;GO:0031526|brush border membrane;","GO:0005326|neurotransmitter transporter activity;GO:0005337|nucleoside transmembrane transporter activity;GO:0005345|purine nucleobase transmembrane transporter activity;GO:0005415|nucleoside:sodium symporter activity;GO:0015211|purine nucleoside transmembrane transporter activity;GO:0015213|uridine transmembrane transporter activity;GO:0015293|symporter activity;GO:0015389|pyrimidine- and adenine-specific:sodium symporter activity;","K11536","SLC28A; pyrimidine nucleoside transport protein"]
["ENSRNOG00000000196",1241,103.0360857,365,23.48060994,4.388134975,2.133607903,{"v":2.1578e-163,"d":"2.16E-163"},{"v":6.6014e-162,"d":"6.60E-162"},"up","yes","Cyp19a1","protein_coding","chr8:54553165-54580758:-","gi|281182626|ref|NP_058781.2|",2553,0,"aromatase [Rattus norvegicus]","gi|281182625|ref|NM_017085.2|",2525,0,"Rattus norvegicus cytochrome P450, family 19, subfamily a, polypeptide 1 (Cyp19a1), mRNA","P22443",963,0,"Aromatase","VNG0422G",97.1,{"v":1e-20,"d":"1.00E-20"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0001553|luteinization;GO:0002677|negative regulation of chronic inflammatory response;GO:0006703|estrogen biosynthetic process;GO:0006710|androgen catabolic process;GO:0008206|bile acid metabolic process;GO:0008207|C21-steroid hormone metabolic process;GO:0008209|androgen metabolic process;GO:0008584|male gonad development;GO:0008585|female gonad development;GO:0009410|response to xenobiotic stimulus;GO:0009635|response to herbicide;GO:0010038|response to metal ion;GO:0010164|response to cesium ion;GO:0010212|response to ionizing radiation;GO:0010760|negative regulation of macrophage chemotaxis;GO:0014070|response to organic cyclic compound;GO:0018879|biphenyl metabolic process;GO:0018894|dibenzo-p-dioxin metabolic process;GO:0018963|phthalate metabolic process;GO:0021766|hippocampus development;GO:0021854|hypothalamus development;GO:0030186|melatonin metabolic process;GO:0030325|adrenal gland development;GO:0030540|female genitalia development;GO:0030851|granulocyte differentiation;GO:0030879|mammary gland development;GO:0032355|response to estradiol;GO:0033574|response to testosterone;GO:0043278|response to morphine;GO:0043627|response to estrogen;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0045779|negative regulation of bone resorption;GO:0050803|regulation of synapse structure or activity;GO:0060065|uterus development;GO:0060348|bone development;GO:0060736|prostate gland growth;GO:0061370|testosterone biosynthetic process;GO:0071333|cellular response to glucose stimulus;GO:0071371|cellular response to gonadotropin stimulus;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0071464|cellular response to hydrostatic pressure;GO:0097720|calcineurin-mediated signaling;GO:2000866|positive regulation of estradiol secretion;","GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;GO:0008021|synaptic vesicle;GO:0016020|membrane;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0043197|dendritic spine;GO:0043679|axon terminus;GO:0045202|synapse;","GO:0005506|iron ion binding;GO:0016712|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0020037|heme binding;GO:0070330|aromatase activity;","K07434","CYP19A; aromatase [EC:1.14.14.14]"]
["ENSRNOG00000052981",1203,99.88107261,345,22.19400117,4.500363491,2.170041532,{"v":8.2752e-162,"d":"8.28E-162"},{"v":2.5077e-160,"d":"2.51E-160"},"up","yes","AABR07058464.1","protein_coding","chr7:109131064-109147649:-","gi|392341539|ref|XP_003754362.1|",1532,0,"PREDICTED: apolipoprotein L3-like isoform X1 [Rattus norvegicus]","gi|672022074|ref|XM_008776507.1|",1945,0,"PREDICTED: Rattus norvegicus apolipoprotein L3-like (LOC100910885), transcript variant X1, mRNA","O95236",195,{"v":8e-54,"d":"8.00E-54"},"Apolipoprotein L3",".",".",".",".","pfam05461","ApoL","Apolipoprotein L. Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.",".",".",".",".","."]
["ENSRNOG00000002470",1336,110.9236185,433,27.85507973,3.982168406,1.993554234,{"v":3.125E-161,"d":"3.13E-161"},{"v":9.3809e-160,"d":"9.38E-160"},"up","yes","Ifi47","protein_coding","chr10:33285450-33306216:+","gi|672067229|ref|XP_008765884.1|",2158,0,"PREDICTED: interferon gamma inducible protein 47 isoform X2 [Rattus norvegicus]","gi|672067230|ref|XM_006246175.2|",3717,0,"PREDICTED: Rattus norvegicus interferon gamma inducible protein 47 (Ifi47), transcript variant X2, mRNA","Q3T9E4",295,{"v":2E-87,"d":"2.00E-87"},"T-cell-specific guanine nucleotide triphosphate-binding protein 2",".",".",".",".","pfam05049","IIGP","Interferon-inducible GTPase (IIGP). Interferon-inducible GTPase (IIGP) is thought to play a role in in intracellular defence. IIGP is predominantly associated with the Golgi apparatus and also localizes to the endoplasmic reticulum and exerts a distinct role in IFN-induced intracellular membrane trafficking or processing.","GO:0006952|defense response;GO:0035458|cellular response to interferon-beta;","GO:0005789|endoplasmic reticulum membrane;","GO:0003924|GTPase activity;GO:0005525|GTP binding;","K17072","IFI47; interferon gamma inducible protein 47"]
["ENSRNOG00000016826",604,50.14810296,26,1.672591393,29.9822797,4.906038177,{"v":6.9992e-161,"d":"7.00E-161"},{"v":2.0913E-159,"d":"2.09E-159"},"up","yes","Pla2g2d","protein_coding","chr5:151018870-151022525:+","gi|149024390|gb|EDL80887.1|",994,{"v":4e-128,"d":"4.00E-128"},"phospholipase A2, group IID [Rattus norvegicus]","gi|61740622|ref|NM_001013428.1|",1830,0,"Rattus norvegicus phospholipase A2, group IID (Pla2g2d), mRNA","Q9WVF6",261,{"v":6e-82,"d":"6.00E-82"},"Group IID secretory phospholipase A2",".",".",".",".","pfam00068","Phospholip_A2_1","Phospholipase A2. Phospholipase A2 releases fatty acids from the second carbon group of glycerol. Perhaps the best known members are secreted snake venoms, but also found in secreted pancreatic and membrane-associated forms. Structure is all-alpha, with two core disulfide-linked helices and a calcium-binding loop. This alignment represents the major family of PLA2s. A second minor family, defined by the honeybee venom PLA2 PDB:1POC and related sequences from Gila monsters (Heloderma), is not recognized. This minor family conserves the core helix pair but is substantially different elsewhere. The PROSITE pattern PA2_HIS, specific to the first core helix, recognizes both families.","GO:0002361|CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0002864|regulation of acute inflammatory response to antigenic stimulus;GO:0006644|phospholipid metabolic process;GO:0016042|lipid catabolic process;GO:0042130|negative regulation of T cell proliferation;GO:0046337|phosphatidylethanolamine metabolic process;GO:0046470|phosphatidylcholine metabolic process;GO:0046471|phosphatidylglycerol metabolic process;GO:0050482|arachidonic acid secretion;GO:0050868|negative regulation of T cell activation;","GO:0005576|extracellular region;","GO:0004623|phospholipase A2 activity;GO:0005509|calcium ion binding;GO:0005543|phospholipid binding;GO:0008201|heparin binding;GO:0043395|heparan sulfate proteoglycan binding;GO:0047498|calcium-dependent phospholipase A2 activity;","K01047","PLA2G, SPLA2; secretory phospholipase A2 [EC:3.1.1.4]"]
["ENSRNOG00000023969",897,74.47491449,169,10.87184405,6.850255957,2.776157895,{"v":4.5586e-160,"d":"4.56E-160"},{"v":1.3432E-158,"d":"1.34E-158"},"up","yes","Herc6","protein_coding","chr4:87524493-87581744:-","gi|55249804|gb|AAH85921.1|",5197,0,"Herc6 protein, partial [Rattus norvegicus]","gi|672049854|ref|XM_008762963.1|",4089,0,"PREDICTED: Rattus norvegicus HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 (Herc6), transcript variant X2, mRNA","F2Z461",1543,0,"E3 ISG15--protein ligase Herc6","SPBP8B7.27",154,{"v":5e-37,"d":"5.00E-37"},"COG5021","pfam00632","HECT","HECT-domain (ubiquitin-transferase). The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.","GO:0002244|hematopoietic progenitor cell differentiation;GO:0009617|response to bacterium;GO:0016567|protein ubiquitination;","GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0004842|ubiquitin-protein transferase activity;","K22372","HERC5_6; E3 ISG15--protein ligase [EC:2.3.2.-]"]
["ENSRNOG00000049115",754,62.60210204,100,6.433043818,9.731334622,3.28263768,{"v":7.2939e-158,"d":"7.29E-158"},{"v":2.1008e-156,"d":"2.10E-156"},"up","yes","Ccr5","protein_coding","chr8:123752325-123759260:+","gi|51592090|ref|NP_446412.2|",1670,0,"C-C chemokine receptor type 5 [Rattus norvegicus]","gi|82617607|ref|NM_053960.3|",2492,0,"Rattus norvegicus chemokine (C-C motif) receptor 5 (Ccr5), mRNA","O08556",639,0,"C-C chemokine receptor type 5",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0000165|MAPK cascade;GO:0002437|inflammatory response to antigenic stimulus;GO:0006816|calcium ion transport;GO:0006935|chemotaxis;GO:0006952|defense response;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007267|cell-cell signaling;GO:0007568|aging;GO:0010212|response to ionizing radiation;GO:0010628|positive regulation of gene expression;GO:0014808|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0019722|calcium-mediated signaling;GO:0022409|positive regulation of cell-cell adhesion;GO:0023052|signaling;GO:0030336|negative regulation of cell migration;GO:0030517|negative regulation of axon extension;GO:0030900|forebrain development;GO:0031622|positive regulation of fever generation;GO:0032496|response to lipopolysaccharide;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032755|positive regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0042742|defense response to bacterium;GO:0045444|fat cell differentiation;GO:0045666|positive regulation of neuron differentiation;GO:0050729|positive regulation of inflammatory response;GO:0050900|leukocyte migration;GO:0060139|positive regulation of apoptotic process by virus;GO:0060326|cell chemotaxis;GO:0070098|chemokine-mediated signaling pathway;GO:0070723|response to cholesterol;GO:0070997|neuron death;GO:0071222|cellular response to lipopolysaccharide;GO:2000110|negative regulation of macrophage apoptotic process;GO:2000178|negative regulation of neural precursor cell proliferation;","GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0003779|actin binding;GO:0005515|protein binding;GO:0016493|C-C chemokine receptor activity;GO:0019901|protein kinase binding;GO:0019957|C-C chemokine binding;GO:0042802|identical protein binding;GO:0071791|chemokine (C-C motif) ligand 5 binding;","K04180","CCR5, CD195; C-C chemokine receptor type 5"]
["ENSRNOG00000050395",904,75.05610111,186,11.9654615,6.272729313,2.649093307,{"v":1.3864E-153,"d":"1.39E-153"},{"v":3.8712e-152,"d":"3.87E-152"},"up","yes","Ms4a6bl","protein_coding","chr1:208243559-208257340:+","gi|55741532|ref|NP_001006976.1|",1233,{"v":7e-158,"d":"7.00E-158"},"membrane-spanning 4-domains, subfamily A, member 6B-like [Rattus norvegicus]","gi|298888539|emb|FQ230476.1|",3286,0,"Rattus norvegicus TL0AEA98YI12 mRNA sequence","Q99N09",366,{"v":2E-116,"d":"2.00E-116"},"Membrane-spanning 4-domains subfamily A member 6B",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.",".","GO:0016021|integral component of membrane;",".","K22191","MS4A5_6_7; membrane-spanning 4-domains subfamily A member 5/6/7"]
["ENSRNOG00000018247",719,59.69616892,94,6.047061189,9.871930686,3.303332265,{"v":1.9615E-151,"d":"1.96E-151"},{"v":5.4293e-150,"d":"5.43E-150"},"up","yes","Dhx58","protein_coding","chr10:85620357-85631525:-","gi|149408137|ref|NP_001092258.1|",3585,0,"probable ATP-dependent RNA helicase DHX58 [Rattus norvegicus]","gi|672068688|ref|XM_006247315.2|",2373,0,"PREDICTED: Rattus norvegicus DEXH (Asp-Glu-X-His) box polypeptide 58 (Dhx58), transcript variant X2, mRNA","Q99J87",1266,0,"Probable ATP-dependent RNA helicase DHX58","TVN1490",130,{"v":5e-31,"d":"5.00E-31"},"COG1111","pfam11648","RIG-I_C-RD","C-terminal domain of RIG-I. This family of proteins represents the regulatory domain RD of RIG-I, a protein which initiates a signalling cascade that provides essential antiviral protection for the host. The RD domain binds viral RNA, activating the RIG-I ATPase by RNA-dependant dimerization. The structure of RD contains a zinc-binding domain and is thought to confer ligand specificity.","GO:0009615|response to virus;GO:0009617|response to bacterium;GO:0032480|negative regulation of type I interferon production;GO:0032481|positive regulation of type I interferon production;GO:0032728|positive regulation of interferon-beta production;GO:0039534|negative regulation of MDA-5 signaling pathway;GO:0039536|negative regulation of RIG-I signaling pathway;GO:0045087|innate immune response;GO:0045088|regulation of innate immune response;GO:0045824|negative regulation of innate immune response;GO:0051607|defense response to virus;GO:1900245|positive regulation of MDA-5 signaling pathway;GO:1900246|positive regulation of RIG-I signaling pathway;","GO:0005737|cytoplasm;","GO:0003677|DNA binding;GO:0003724|RNA helicase activity;GO:0003725|double-stranded RNA binding;GO:0003727|single-stranded RNA binding;GO:0005524|ATP binding;GO:0008270|zinc ion binding;","K12649","DHX58, LGP2; ATP-dependent RNA helicase DHX58 [EC:3.6.4.13]"]
["ENSRNOG00000014610",1250,103.7833257,405,26.05382746,3.983419549,1.994007438,{"v":4.9984e-151,"d":"5.00E-151"},{"v":1.3776e-149,"d":"1.38E-149"},"up","yes","Anpep","protein_coding","chr1:133767332-133785789:-","gi|564329002|ref|XP_006229469.1|",4869,0,"PREDICTED: aminopeptidase N isoform X1 [Rattus norvegicus]","gi|672037160|ref|XM_006229408.2|",3319,0,"PREDICTED: Rattus norvegicus alanyl (membrane) aminopeptidase (Anpep), transcript variant X2, mRNA","P15684",1877,0,"Aminopeptidase N","YHR047c",377,{"v":3e-113,"d":"3.00E-113"},"COG0308","pfam01433","Peptidase_M1","Peptidase family M1. Members of this family are aminopeptidases. The members differ widely in specificity, hydrolysing acidic, basic or neutral N-terminal residues. This family includes leukotriene-A4 hydrolase, this enzyme also has an aminopeptidase activity.","GO:0001525|angiogenesis;GO:0006508|proteolysis;GO:0007165|signal transduction;GO:0008217|regulation of blood pressure;GO:0030154|cell differentiation;GO:0035814|negative regulation of renal sodium excretion;GO:0043171|peptide catabolic process;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005793|endoplasmic reticulum-Golgi intermediate compartment;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0031526|brush border membrane;GO:0070062|extracellular exosome;","GO:0004177|aminopeptidase activity;GO:0008237|metallopeptidase activity;GO:0008270|zinc ion binding;GO:0042277|peptide binding;GO:0070006|metalloaminopeptidase activity;","K11140","ANPEP, CD13; aminopeptidase N [EC:3.4.11.2]"]
["ENSRNOG00000019542",1452,120.5547111,546,35.12441925,3.432219341,1.779141753,{"v":1.8067e-150,"d":"1.81E-150"},{"v":4.9582e-149,"d":"4.96E-149"},"up","yes","MGC108823","protein_coding","chr18:53748631-53772834:+","gi|59891429|ref|NP_001012353.1|",2134,0,"uncharacterized protein LOC307414 [Rattus norvegicus]","gi|564320684|ref|XM_006222578.1|",1851,0,"PREDICTED: Rattus norvegicus interferon-inducible GTPase 1-like (LOC102549198), mRNA","Q9QZ85",606,0,"Interferon-inducible GTPase 1",".",".",".",".","pfam05049","IIGP","Interferon-inducible GTPase (IIGP). Interferon-inducible GTPase (IIGP) is thought to play a role in in intracellular defence. IIGP is predominantly associated with the Golgi apparatus and also localizes to the endoplasmic reticulum and exerts a distinct role in IFN-induced intracellular membrane trafficking or processing.","GO:0006952|defense response;GO:0035458|cellular response to interferon-beta;","GO:0005789|endoplasmic reticulum membrane;GO:0016020|membrane;","GO:0003924|GTPase activity;GO:0005525|GTP binding;",".","."]
["ENSRNOG00000023410",612,50.81231624,48,3.087861033,16.45550616,4.040498498,{"v":2.1487e-149,"d":"2.15E-149"},{"v":5.7971e-148,"d":"5.80E-148"},"up","yes","Apol9a","protein_coding","chr7:109140871-109147649:-","gi|68163567|ref|NP_001020237.1|",1533,0,"apolipoprotein L 9a [Rattus norvegicus]","gi|68163566|ref|NM_001025066.1|",1568,0,"Rattus norvegicus apolipoprotein L 9a (Apol9a), mRNA","O95236",162,{"v":1E-42,"d":"1.00E-42"},"Apolipoprotein L3",".",".",".",".","pfam05461","ApoL","Apolipoprotein L. Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.","GO:0006869|lipid transport;GO:0042157|lipoprotein metabolic process;","GO:0005576|extracellular region;","GO:0008289|lipid binding;","K14480","APOL; apolipoprotein L"]
["ENSRNOG00000065208",582,48.32151643,35,2.251565336,21.46129879,4.423665482,{"v":4.0345e-149,"d":"4.03E-149"},{"v":1.0839E-147,"d":"1.08E-147"},"up","yes","ENSRNOG00000065208","protein_coding","chr13:85912044-85929007:-","gi|564316191|ref|XP_006221623.1|",4558,0,"PREDICTED: flocculation protein FLO11-like isoform X1 [Rattus norvegicus]","gi|672027392|ref|XM_006221562.2|",3303,0,"PREDICTED: Rattus norvegicus pyrin domain-containing protein 3-like (LOC102556096), transcript variant X2, mRNA","Q3V3Q4",430,{"v":1E-135,"d":"1.00E-135"},"Pyrin domain-containing protein 3",".",".",".",".","pfam02760","HIN","HIN-200/IF120x domain. This domain has no know function. It is found in one or two copies per protein, and is found associated with the PAAD/DAPIN domain pfam02758.",".",".",".",".","."]
["ENSRNOG00000037853",800,66.42132842,149,9.58523529,6.929545954,2.792760825,{"v":7.5327E-144,"d":"7.53E-144"},{"v":1.9903E-142,"d":"1.99E-142"},"up","yes","Rarres1","protein_coding","chr2:151749715-151783978:-","gi|62339361|ref|NP_001014790.1|",1366,0,"retinoic acid receptor responder protein 1 precursor [Rattus norvegicus]","gi|114205614|gb|BC105631.1|",1329,0,"Rattus norvegicus retinoic acid receptor responder (tazarotene induced) 1, mRNA (cDNA clone MGC:124894 IMAGE:7386690), complete cds","P49788",405,{"v":4e-138,"d":"4.00E-138"},"Retinoic acid receptor responder protein 1",".",".",".",".","pfam06907","Latexin","Latexin. This family consists of several animal specific latexin proteins. Latexin is a carboxypeptidase A inhibitor and is expressed in a cell type-specific manner in both central and peripheral nervous systems in the rat.","GO:0008285|negative regulation of cell proliferation;GO:0010951|negative regulation of endopeptidase activity;","GO:0005615|extracellular space;","GO:0008191|metalloendopeptidase inhibitor activity;","K23595","RARRES1; retinoic acid receptor responder protein 1"]
["ENSRNOG00000037371",738,61.27367547,120,7.719652582,7.937361794,2.988659567,{"v":5.076E-142,"d":"5.08E-142"},{"v":1.3194E-140,"d":"1.32E-140"},"up","yes","Xaf1","protein_coding","chr10:56917121-56929770:+","gi|564312948|ref|XP_006220783.1|",1492,0,"PREDICTED: XIAP-associated factor 1 [Rattus norvegicus]","gi|672024934|ref|XM_006220721.2|",1665,0,"PREDICTED: Rattus norvegicus XIAP associated factor-1 (XAF1), mRNA","Q5NBU8",441,{"v":7e-149,"d":"7.00E-149"},"XIAP-associated factor 1",".",".",".",".","pfam12230","PRP21_like_P","Pre-mRNA splicing factor PRP21 like protein. This domain family is found in eukaryotes, and is typically between 212 and 238 amino acids in length. The family is found in association with pfam01805. There are two completely conserved residues (W and H) that may be functionally important. PRP21 is required for assembly of the prespliceosome and it interacts with U2 snRNP and/or pre-mRNA in the prespliceosome. This family also contains proteins similar to PRP21, such as the mammalian SF3a. SF3a also interacts with U2 snRNP from the prespliceosome, converting it to its active form.","GO:0006915|apoptotic process;GO:0031333|negative regulation of protein complex assembly;GO:0035456|response to interferon-beta;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005739|mitochondrion;","GO:0005515|protein binding;",".","."]
["ENSRNOG00000029145",910,75.55426108,216,13.89537465,5.437367685,2.442908389,{"v":2.241e-141,"d":"2.24E-141"},{"v":5.8014e-140,"d":"5.80E-140"},"up","yes","AY172581.2","Mt_tRNA","chrMT:15348-15415:-",".",".",".",".","gi|755572967|gb|KP244683.1|",68,{"v":2e-26,"d":"2.00E-26"},"Rattus norvegicus isolate 115 mitochondrion, complete genome",".",".",".",".",".",".",".",".","pfam02514","CobN-Mg_chel","CobN/Magnesium Chelatase. This family contains a domain common to the cobN protein and to magnesium protoporphyrin chelatase. CobN is implicated in the conversion of hydrogenobyrinic acid a,c-diamide to cobyrinic acid. Magnesium protoporphyrin chelatase is involved in chlorophyll biosynthesis.",".",".",".",".","."]
["ENSRNOG00000017869",1060,88.00826016,316,20.32841847,4.329321551,2.114140957,{"v":2.8706e-138,"d":"2.87E-138"},{"v":7.2837e-137,"d":"7.28E-137"},"up","yes","Irf8","protein_coding","chr19:48790588-48811829:+","gi|56790291|ref|NP_001008722.1|",2280,0,"interferon regulatory factor 8 [Rattus norvegicus]","gi|672085188|ref|XM_006255737.2|",2278,0,"PREDICTED: Rattus norvegicus interferon regulatory factor 8 (Irf8), transcript variant X1, mRNA","P23611",849,0,"Interferon regulatory factor 8",".",".",".",".","pfam10401","IRF-3","Interferon-regulatory factor 3. This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1).  Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0002273|plasmacytoid dendritic cell differentiation;GO:0002314|germinal center B cell differentiation;GO:0002316|follicular B cell differentiation;GO:0002376|immune system process;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006909|phagocytosis;GO:0006955|immune response;GO:0009617|response to bacterium;GO:0030099|myeloid cell differentiation;GO:0032479|regulation of type I interferon production;GO:0032729|positive regulation of interferon-gamma production;GO:0032735|positive regulation of interleukin-12 production;GO:0042742|defense response to bacterium;GO:0042832|defense response to protozoan;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0060261|positive regulation of transcription initiation from RNA polymerase II promoter;GO:0071222|cellular response to lipopolysaccharide;GO:0071346|cellular response to interferon-gamma;GO:0097028|dendritic cell differentiation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0005515|protein binding;GO:1990837|sequence-specific double-stranded DNA binding;","K10155","IRF8; interferon regulatory factor 8"]
["ENSRNOG00000037409",544,45.16650333,38,2.444556651,18.47635779,4.207608484,{"v":4.3822e-136,"d":"4.38E-136"},{"v":1.0945E-134,"d":"1.09E-134"},"up","yes","Scimp","protein_coding","chr10:55507519-55528171:-","gi|293351630|ref|XP_001080739.2|",669,{"v":3e-82,"d":"3.00E-82"},"PREDICTED: SLP adapter and CSK-interacting membrane protein isoform X2 [Rattus norvegicus]","gi|672024902|ref|XM_003752341.3|",1057,0,"PREDICTED: Rattus norvegicus SLP adaptor and CSK interacting membrane protein (Scimp), transcript variant X1, mRNA","Q3UU41",220,{"v":2e-67,"d":"2.00E-67"},"SLP adapter and CSK-interacting membrane protein",".",".",".",".","pfam15050","SCIMP","SCIMP protein. This family contains the SCIMP proteins which are a a transmembrane adaptor protein involved in major histocompatibility complex class II signaling.","GO:0002720|positive regulation of cytokine production involved in immune response;GO:0002732|positive regulation of dendritic cell cytokine production;GO:0031666|positive regulation of lipopolysaccharide-mediated signaling pathway;GO:0032735|positive regulation of interleukin-12 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032874|positive regulation of stress-activated MAPK cascade;GO:0034138|toll-like receptor 3 signaling pathway;GO:0034142|toll-like receptor 4 signaling pathway;GO:0034154|toll-like receptor 7 signaling pathway;GO:0038123|toll-like receptor TLR1:TLR2 signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071226|cellular response to molecule of fungal origin;","GO:0001726|ruffle;GO:0001772|immunological synapse;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030175|filopodium;GO:0031256|leading edge membrane;GO:0031259|uropod membrane;GO:0043235|receptor complex;GO:0045335|phagocytic vesicle;GO:0097197|tetraspanin-enriched microdomain;","GO:0060090|molecular adaptor activity;",".","."]
["ENSRNOG00000021750",1600,132.8426568,716,46.06059374,2.884084769,1.528113569,{"v":1.1484e-133,"d":"1.15E-133"},{"v":2.8242e-132,"d":"2.82E-132"},"up","yes","Id1","protein_coding","chr3:141211267-141212419:+","gi|564343661|ref|XP_006235329.1|",716,{"v":1E-91,"d":"1.00E-91"},"PREDICTED: DNA-binding protein inhibitor ID-1 isoform X1 [Rattus norvegicus]","gi|672047400|ref|XM_006235267.2|",935,0,"PREDICTED: Rattus norvegicus inhibitor of DNA binding 1 (Id1), transcript variant X1, mRNA","P41135",242,{"v":4E-78,"d":"4.00E-78"},"DNA-binding protein inhibitor ID-1",".",".",".",".","pfam00010","HLH","Helix-loop-helix DNA-binding domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001886|endothelial cell morphogenesis;GO:0007420|brain development;GO:0007507|heart development;GO:0007623|circadian rhythm;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0014070|response to organic cyclic compound;GO:0030154|cell differentiation;GO:0030182|neuron differentiation;GO:0030509|BMP signaling pathway;GO:0031648|protein destabilization;GO:0032091|negative regulation of protein binding;GO:0032233|positive regulation of actin filament bundle assembly;GO:0032922|circadian regulation of gene expression;GO:0032963|collagen metabolic process;GO:0036164|cell-abiotic substrate adhesion;GO:0043066|negative regulation of apoptotic process;GO:0043392|negative regulation of DNA binding;GO:0043408|regulation of MAPK cascade;GO:0043433|negative regulation of DNA-binding transcription factor activity;GO:0045602|negative regulation of endothelial cell differentiation;GO:0045668|negative regulation of osteoblast differentiation;GO:0045765|regulation of angiogenesis;GO:0045892|negative regulation of transcription, DNA-templated;GO:0046677|response to antibiotic;GO:0050679|positive regulation of epithelial cell proliferation;GO:0050774|negative regulation of dendrite morphogenesis;GO:0060425|lung morphogenesis;GO:0060426|lung vasculature development;GO:0071364|cellular response to epidermal growth factor stimulus;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0120163|negative regulation of cold-induced thermogenesis;GO:1901342|regulation of vasculature development;GO:1901653|cellular response to peptide;GO:1903351|cellular response to dopamine;GO:1990090|cellular response to nerve growth factor stimulus;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005813|centrosome;","GO:0005515|protein binding;GO:0008022|protein C-terminus binding;GO:0042802|identical protein binding;GO:0043621|protein self-association;GO:0046983|protein dimerization activity;GO:0047485|protein N-terminus binding;GO:0070628|proteasome binding;GO:0140110|transcription regulator activity;","K04680","ID1; DNA-binding protein inhibitor ID1"]
["ENSRNOG00000006231",530,44.00413008,36,2.315895775,19.00091125,4.247996704,{"v":2.6506e-133,"d":"2.65E-133"},{"v":6.4937e-132,"d":"6.49E-132"},"up","yes","Ptpro","protein_coding","chr4:170164431-170374771:+","gi|8394227|ref|NP_059032.1|",6061,0,"receptor-type tyrosine-protein phosphatase O precursor [Rattus norvegicus]","gi|8394226|ref|NM_017336.1|",4850,0,"Rattus norvegicus protein tyrosine phosphatase, receptor type, O (Ptpro), mRNA","E9Q612",2241,0,"Receptor-type tyrosine-protein phosphatase O","SPAC11E3.09",168,{"v":2e-44,"d":"2.00E-44"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0000902|cell morphogenesis;GO:0002548|monocyte chemotaxis;GO:0003093|regulation of glomerular filtration;GO:0003105|negative regulation of glomerular filtration;GO:0007399|nervous system development;GO:0007411|axon guidance;GO:0030032|lamellipodium assembly;GO:0032835|glomerulus development;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0036060|slit diaphragm assembly;GO:0050807|regulation of synapse organization;GO:0072112|glomerular visceral epithelial cell differentiation;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:1990264|peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity;","GO:0005886|plasma membrane;GO:0016324|apical plasma membrane;GO:0016328|lateral plasma membrane;GO:0043197|dendritic spine;GO:0098978|glutamatergic synapse;GO:0098982|GABA-ergic synapse;GO:0099061|integral component of postsynaptic density membrane;","GO:0004725|protein tyrosine phosphatase activity;GO:0017147|Wnt-protein binding;GO:0042803|protein homodimerization activity;GO:0045296|cadherin binding;","K18035","PTPRO; receptor-type tyrosine-protein phosphatase O [EC:3.1.3.48]"]
["ENSRNOG00000013820",554,45.99676993,47,3.023530595,15.21293352,3.927226471,{"v":4.257e-133,"d":"4.26E-133"},{"v":1.0389E-131,"d":"1.04E-131"},"up","yes","Tnfrsf14","protein_coding","chr5:165484262-165493703:-","gi|564354542|ref|XP_006239648.1|",1218,{"v":6e-154,"d":"6.00E-154"},"PREDICTED: tumor necrosis factor receptor superfamily member 14 isoform X1 [Rattus norvegicus]","gi|672054990|ref|XR_354472.2|",2791,0,"PREDICTED: Rattus norvegicus tumor necrosis factor receptor superfamily, member 14 (Tnfrsf14), transcript variant X2, misc_RNA","Q92956",177,{"v":2e-47,"d":"2.00E-47"},"Tumor necrosis factor receptor superfamily member 14",".",".",".",".","pfam00020","TNFR_c6","TNFR/NGFR cysteine-rich region.","GO:0002720|positive regulation of cytokine production involved in immune response;GO:0008150|biological_process;GO:0031295|T cell costimulation;GO:0046642|negative regulation of alpha-beta T cell proliferation;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:1905675|negative regulation of adaptive immune memory response;GO:2000406|positive regulation of T cell migration;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0019955|cytokine binding;GO:0031625|ubiquitin protein ligase binding;","K05152","TNFRSF14, HVEM, CD270; tumor necrosis factor receptor superfamily member 14"]
["ENSRNOG00000033220",505,41.92846357,28,1.801252269,23.27739667,4.540857812,{"v":3.7125e-131,"d":"3.71E-131"},{"v":8.9918e-130,"d":"8.99E-130"},"up","yes","Oas1k","protein_coding","chr12:35724055-35735242:-","gi|148747317|ref|NP_653353.2|",1709,0,"inactive 2'-5'-oligoadenylate synthase 1B [Rattus norvegicus]","gi|3192926|gb|AF068268.1|",2111,0,"Rattus norvegicus 2'5' oligoadenylate synthetase-2 mRNA, complete cds","Q5BKD0",662,0,"Inactive 2'-5'-oligoadenylate synthase 1B",".",".",".",".","pfam10421","OAS1_C","2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus. This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between 320 and 344 at the extreme C-terminal end. Oligoadenylate synthetases are antiviral enzymes that counteract vial attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesize 2'.5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication. This domain is often associated with NTP_transf_2 pfam01909.","GO:0009615|response to virus;GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0051607|defense response to virus;GO:0060700|regulation of ribonuclease activity;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005789|endoplasmic reticulum membrane;GO:0005829|cytosol;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0001730|2'-5'-oligoadenylate synthetase activity;GO:0003725|double-stranded RNA binding;","K14216","OAS; 2'-5'-oligoadenylate synthetase [EC:2.7.7.84]"]
["ENSRNOG00000009342",489,40.600037,6,0.385982629,105.1861766,6.71680131,{"v":9.9873e-131,"d":"9.99E-131"},{"v":2.4098E-129,"d":"2.41E-129"},"up","yes","Fcnb","protein_coding","chr3:11393739-11402151:-","gi|16758442|ref|NP_446086.1|",1695,0,"ficolin-2 precursor [Rattus norvegicus]","gi|298888542|emb|FQ220557.1|",1162,0,"Rattus norvegicus TL0ADA42YH06 mRNA sequence","P57756",657,0,"Ficolin-2",".",".",".",".","pfam00147","Fibrinogen_C","Fibrinogen beta and gamma chains, C-terminal globular domain.","GO:0001867|complement activation, lectin pathway;GO:0002752|cell surface pattern recognition receptor signaling pathway;GO:0007186|G protein-coupled receptor signaling pathway;GO:0032757|positive regulation of interleukin-8 production;GO:0034394|protein localization to cell surface;GO:0043654|recognition of apoptotic cell;GO:0046597|negative regulation of viral entry into host cell;","GO:0005581|collagen trimer;GO:0005615|extracellular space;GO:0031232|extrinsic component of external side of plasma membrane;GO:0062023|collagen-containing extracellular matrix;","GO:0001664|G protein-coupled receptor binding;GO:0003823|antigen binding;GO:0005102|signaling receptor binding;GO:0030246|carbohydrate binding;GO:0033691|sialic acid binding;GO:0038187|pattern recognition receptor activity;GO:0046872|metal ion binding;GO:0097367|carbohydrate derivative binding;","K10104","FCN; ficolin"]
["ENSRNOG00000037563",1622,134.6692434,749,48.1834982,2.794924578,1.482809352,{"v":1.1421e-129,"d":"1.14E-129"},{"v":2.7453e-128,"d":"2.75E-128"},"up","yes","Cd68","protein_coding","chr10:54381815-54383697:-","gi|72255507|ref|NP_001026808.1|",1022,{"v":2e-133,"d":"2.00E-133"},"macrosialin precursor [Rattus norvegicus]","gi|72255506|ref|NM_001031638.1|",1107,0,"Rattus norvegicus Cd68 molecule (Cd68), mRNA","P31996",348,{"v":1e-115,"d":"1.00E-115"},"Macrosialin",".",".",".",".","pfam01299","Lamp","Lysosome-associated membrane glycoprotein (Lamp).","GO:0002437|inflammatory response to antigenic stimulus;GO:0002605|negative regulation of dendritic cell antigen processing and presentation;GO:0007568|aging;GO:0031669|cellular response to nutrient levels;GO:0035425|autocrine signaling;GO:0071222|cellular response to lipopolysaccharide;GO:0071310|cellular response to organic substance;GO:0072594|establishment of protein localization to organelle;GO:0140052|cellular response to oxidised low-density lipoprotein particle stimulus;","GO:0005764|lysosome;GO:0005765|lysosomal membrane;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0031902|late endosome membrane;",".","K06501","CD68; CD68 antigen"]
["ENSRNOG00000026235",593,49.23480969,72,4.631791549,10.62975507,3.410036449,{"v":1.4338E-128,"d":"1.43E-128"},{"v":3.3955e-127,"d":"3.40E-127"},"up","yes","Hk3","protein_coding","chr17:9599865-9614863:+","gi|564390462|ref|XP_006253664.1|",4788,0,"PREDICTED: hexokinase-3 isoform X1 [Rattus norvegicus]","gi|672081088|ref|XM_008771484.1|",2987,0,"PREDICTED: Rattus norvegicus hexokinase 3 (white cell) (Hk3), transcript variant X2, mRNA","P27926",1846,0,"Hexokinase-3","SPAC24H6.04",276,{"v":7e-81,"d":"7.00E-81"},"COG5026","pfam03727","Hexokinase_2","Hexokinase. Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam00349. Some members of the family have two copies of each of these domains.","GO:0001678|cellular glucose homeostasis;GO:0006002|fructose 6-phosphate metabolic process;GO:0006096|glycolytic process;GO:0008150|biological_process;GO:0019318|hexose metabolic process;GO:0046835|carbohydrate phosphorylation;GO:0051156|glucose 6-phosphate metabolic process;GO:1901299|negative regulation of hydrogen peroxide-mediated programmed cell death;","GO:0005739|mitochondrion;GO:0005829|cytosol;GO:0032991|protein-containing complex;","GO:0004340|glucokinase activity;GO:0004396|hexokinase activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0005536|glucose binding;GO:0008865|fructokinase activity;GO:0019158|mannokinase activity;GO:0019899|enzyme binding;GO:0042562|hormone binding;","K00844","HK; hexokinase [EC:2.7.1.1]"]
["ENSRNOG00000012557",1507,125.1211774,665,42.77974139,2.924776386,1.548326327,{"v":1.997e-128,"d":"2.00E-128"},{"v":4.7118e-127,"d":"4.71E-127"},"up","yes","Lgals5","protein_coding","chr10:63853935-63857153:-","gi|149053564|gb|EDM05381.1|",717,{"v":2E-91,"d":"2.00E-91"},"rCG35210 [Rattus norvegicus]","gi|298914355|emb|FQ225984.1|",811,0,"Rattus norvegicus TL0AEA3YH09 mRNA sequence","P47967",264,{"v":1e-86,"d":"1.00E-86"},"Galectin-5",".",".",".",".","pfam00337","Gal-bind_lectin","Galactoside-binding lectin. This family contains galactoside binding lectins.   The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).","GO:0010628|positive regulation of gene expression;GO:0032689|negative regulation of interferon-gamma production;GO:0070234|positive regulation of T cell apoptotic process;GO:2000562|negative regulation of CD4-positive, alpha-beta T cell proliferation;","GO:0005634|nucleus;GO:0005829|cytosol;","GO:0016936|galactoside binding;GO:0030246|carbohydrate binding;GO:0030395|lactose binding;","K17522","LGALS5; galectin-5"]
["ENSRNOG00000022218",1496,124.2078841,668,42.97273271,2.890388307,1.531263324,{"v":1.7633E-125,"d":"1.76E-125"},{"v":4.1e-124,"d":"4.10E-124"},"up","yes","Ifi44","protein_coding","chr2:240626066-240643844:-","gi|157819749|ref|NP_001101199.1|",2131,0,"interferon-induced protein 44 [Rattus norvegicus]","gi|672044490|ref|XM_006233495.2|",1762,0,"PREDICTED: Rattus norvegicus interferon-induced protein 44 (Ifi44), transcript variant X1, mRNA","Q8BV66",610,0,"Interferon-induced protein 44",".",".",".",".","pfam07534","TLD","TLD. This domain is predicted to be an enzyme and is often found associated with pfam01476. It's structure consists of a beta-sandwich surrounded by two helices and two one-turn helices.","GO:0006955|immune response;GO:0009617|response to bacterium;","GO:0005737|cytoplasm;",".",".","."]
["ENSRNOG00000009471",525,43.58899678,46,2.959200157,14.72999272,3.880684813,{"v":2.7972e-125,"d":"2.80E-125"},{"v":6.4803e-124,"d":"6.48E-124"},"up","yes","Epsti1","protein_coding","chr15:53284216-53382191:+","gi|112984176|ref|NP_001037722.1|",1643,0,"epithelial-stromal interaction protein 1 [Rattus norvegicus]","gi|112984175|ref|NM_001044257.1|",1550,0,"Rattus norvegicus epithelial stromal interaction 1 (breast) (Epsti1), mRNA",".",".",".",".",".",".",".",".","pfam15558","DUF4659","Domain of unknown function (DUF4659). This family of proteins is found in eukaryotes. Proteins in this family are typically between 427 and 674 amino acids in length. There are two completely conserved residues (D and I) that may be functionally important.",".",".",".",".","."]
["ENSRNOG00000007690",480,39.85279705,26,1.672591393,23.82697724,4.574524034,{"v":3.8215e-125,"d":"3.82E-125"},{"v":8.8213e-124,"d":"8.82E-124"},"up","yes","Cmpk2","protein_coding","chr6:43073796-43085183:+","gi|564355517|ref|XP_006240000.1|",2101,0,"PREDICTED: UMP-CMP kinase 2, mitochondrial isoform X1 [Rattus norvegicus]","gi|672055803|ref|XM_006239938.2|",3639,0,"PREDICTED: Rattus norvegicus cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial (Cmpk2), transcript variant X1, mRNA","Q3U5Q7",751,0,"UMP-CMP kinase 2, mitochondrial",".",".",".",".","pfam02223","Thymidylate_kin","Thymidylate kinase.","GO:0006165|nucleoside diphosphate phosphorylation;GO:0006227|dUDP biosynthetic process;GO:0006233|dTDP biosynthetic process;GO:0006235|dTTP biosynthetic process;GO:0009142|nucleoside triphosphate biosynthetic process;GO:0046940|nucleoside monophosphate phosphorylation;GO:0071222|cellular response to lipopolysaccharide;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005739|mitochondrion;","GO:0004127|cytidylate kinase activity;GO:0004550|nucleoside diphosphate kinase activity;GO:0004798|thymidylate kinase activity;GO:0009041|uridylate kinase activity;GO:0033862|UMP kinase activity;","K13809","CMPK2; UMP-CMP kinase 2, mitochondrial [EC:2.7.4.14]"]
["ENSRNOG00000003622",661,54.88062261,112,7.205009077,7.617009503,2.929224696,{"v":5.5756e-125,"d":"5.58E-125"},{"v":1.2824E-123,"d":"1.28E-123"},"up","yes","ENSRNOG00000003622","protein_coding","chrX:13359430-13392586:-","gi|16876540|gb|AAG31606.3|AF298656_1",2861,0,"NADPH oxidase beta subunit gp91phox [Rattus norvegicus]","gi|298891875|emb|FQ217794.1|",2923,0,"Rattus norvegicus TL0ACA17YL01 mRNA sequence","Q61093",1075,0,"Cytochrome b-245 heavy chain",".",".",".",".","pfam08030","NAD_binding_6","Ferric reductase NAD binding domain.","GO:0006801|superoxide metabolic process;GO:0006952|defense response;GO:0006954|inflammatory response;GO:0007584|response to nutrient;GO:0009410|response to xenobiotic stimulus;GO:0022900|electron transport chain;GO:0032760|positive regulation of tumor necrosis factor production;GO:0042554|superoxide anion generation;GO:0045087|innate immune response;GO:0045730|respiratory burst;GO:0045766|positive regulation of angiogenesis;GO:0050665|hydrogen peroxide biosynthetic process;GO:0071276|cellular response to cadmium ion;GO:0071361|cellular response to ethanol;GO:0071456|cellular response to hypoxia;GO:0097411|hypoxia-inducible factor-1alpha signaling pathway;GO:1904044|response to aldosterone;GO:1904845|cellular response to L-glutamine;GO:1990776|response to angiotensin;","GO:0005635|nuclear envelope;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005791|rough endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0030425|dendrite;GO:0043020|NADPH oxidase complex;GO:0043025|neuronal cell body;GO:0045335|phagocytic vesicle;GO:0097038|perinuclear endoplasmic reticulum;","GO:0005515|protein binding;GO:0009055|electron transfer activity;GO:0016175|superoxide-generating NADPH oxidase activity;GO:0020037|heme binding;GO:0046982|protein heterodimerization activity;GO:0050660|flavin adenine dinucleotide binding;","K21421","NOX2, GP91, CYBB; NADPH oxidase 2 [EC:1.-.-.-]"]
["ENSRNOG00000049491",990,82.19639392,308,19.81377496,4.148446931,2.05257133,{"v":1.4966e-124,"d":"1.50E-124"},{"v":3.4299e-123,"d":"3.43E-123"},"up","yes","RT1-DMb","protein_coding","chr20:4693103-4700340:-","gi|258613997|ref|NP_942035.2|",1248,{"v":1E-168,"d":"1.00E-168"},"RT1 class II, DM beta precursor [Rattus norvegicus]","gi|672085842|ref|XM_003751925.3|",1292,0,"PREDICTED: Rattus norvegicus class II histocompatibility antigen, M beta 1 chain-like (LOC100909630), mRNA","P35737",421,{"v":6e-145,"d":"6.00E-145"},"Class II histocompatibility antigen, M beta 1 chain",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.","GO:0002250|adaptive immune response;GO:0002399|MHC class II protein complex assembly;GO:0002503|peptide antigen assembly with MHC class II protein complex;GO:0019882|antigen processing and presentation;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0042102|positive regulation of T cell proliferation;GO:0051085|chaperone cofactor-dependent protein refolding;GO:2001190|positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;","GO:0005764|lysosome;GO:0005765|lysosomal membrane;GO:0005770|late endosome;GO:0005771|multivesicular body;GO:0010008|endosome membrane;GO:0016021|integral component of membrane;GO:0031902|late endosome membrane;GO:0042613|MHC class II protein complex;GO:0043231|intracellular membrane-bounded organelle;","GO:0023026|MHC class II protein complex binding;","K06752","MHC2; MHC class II antigen"]
["ENSRNOG00000000853",994,82.52850056,311,20.00676628,4.125029474,2.044404428,{"v":2.0472e-124,"d":"2.05E-124"},{"v":4.6511e-123,"d":"4.65E-123"},"up","yes","Aif1","protein_coding","chr20:3646777-3652668:+","gi|564396944|ref|XP_006256123.1|",572,{"v":1e-65,"d":"1.00E-65"},"PREDICTED: allograft inflammatory factor 1 isoform X1 [Rattus norvegicus]","gi|1049210|gb|U33471.1|RNU33471",1495,0,"Rattus norvegicus balloon angioplasty responsive transcript (BART-1) mRNA, complete cds","P55009",170,{"v":4e-48,"d":"4.00E-48"},"Allograft inflammatory factor 1",".",".",".",".","pfam05110","AF-4","AF-4 proto-oncoprotein. This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.","GO:0001934|positive regulation of protein phosphorylation;GO:0006911|phagocytosis, engulfment;GO:0006954|inflammatory response;GO:0008284|positive regulation of cell proliferation;GO:0010629|negative regulation of gene expression;GO:0014739|positive regulation of muscle hyperplasia;GO:0016601|Rac protein signal transduction;GO:0021549|cerebellum development;GO:0030041|actin filament polymerization;GO:0030046|parallel actin filament bundle assembly;GO:0030335|positive regulation of cell migration;GO:0031668|cellular response to extracellular stimulus;GO:0032722|positive regulation of chemokine production;GO:0032755|positive regulation of interleukin-6 production;GO:0032870|cellular response to hormone stimulus;GO:0034097|response to cytokine;GO:0034599|cellular response to oxidative stress;GO:0042102|positive regulation of T cell proliferation;GO:0042116|macrophage activation;GO:0043066|negative regulation of apoptotic process;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0048662|negative regulation of smooth muscle cell proliferation;GO:0048678|response to axon injury;GO:0050921|positive regulation of chemotaxis;GO:0051017|actin filament bundle assembly;GO:0051384|response to glucocorticoid;GO:0051602|response to electrical stimulus;GO:0051764|actin crosslink formation;GO:0071315|cellular response to morphine;GO:0071346|cellular response to interferon-gamma;GO:0071447|cellular response to hydroperoxide;GO:0071672|negative regulation of smooth muscle cell chemotaxis;GO:0071673|positive regulation of smooth muscle cell chemotaxis;GO:0071677|positive regulation of mononuclear cell migration;GO:0090026|positive regulation of monocyte chemotaxis;GO:0090271|positive regulation of fibroblast growth factor production;GO:0097178|ruffle assembly;GO:1900087|positive regulation of G1/S transition of mitotic cell cycle;GO:2000406|positive regulation of T cell migration;","GO:0001726|ruffle;GO:0001891|phagocytic cup;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005884|actin filament;GO:0030027|lamellipodium;GO:0032587|ruffle membrane;GO:0042995|cell projection;GO:0043204|perikaryon;GO:0048471|perinuclear region of cytoplasm;","GO:0005509|calcium ion binding;GO:0051015|actin filament binding;","K18617","AIF1; allograft inflammatory factor 1"]
["ENSRNOG00000046834",631,52.38982279,99,6.36871338,8.226123498,3.040212731,{"v":1.0848E-123,"d":"1.08E-123"},{"v":2.4252E-122,"d":"2.43E-122"},"up","yes","C3","protein_coding","chr9:2087437-2114429:-","gi|158138561|ref|NP_058690.2|",7781,0,"complement C3 precursor [Rattus norvegicus]","gi|158138560|ref|NM_016994.2|",4433,0,"Rattus norvegicus complement component 3 (C3), mRNA","P01026",2956,0,"Complement C3",".",".",".",".","pfam07678","A2M_comp","A-macroglobulin complement component. This family includes the complement components region of the alpha-2-macroglobulin family.","GO:0001798|positive regulation of type IIa hypersensitivity;GO:0001934|positive regulation of protein phosphorylation;GO:0001970|positive regulation of activation of membrane attack complex;GO:0002507|tolerance induction;GO:0006631|fatty acid metabolic process;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0006956|complement activation;GO:0006957|complement activation, alternative pathway;GO:0006958|complement activation, classical pathway;GO:0007596|blood coagulation;GO:0009617|response to bacterium;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0010828|positive regulation of glucose transmembrane transport;GO:0010866|regulation of triglyceride biosynthetic process;GO:0010884|positive regulation of lipid storage;GO:0010951|negative regulation of endopeptidase activity;GO:0016322|neuron remodeling;GO:0032026|response to magnesium ion;GO:0032355|response to estradiol;GO:0032570|response to progesterone;GO:0035846|oviduct epithelium development;GO:0035886|vascular smooth muscle cell differentiation;GO:0043627|response to estrogen;GO:0045087|innate immune response;GO:0045745|positive regulation of G protein-coupled receptor signaling pathway;GO:0045766|positive regulation of angiogenesis;GO:0048260|positive regulation of receptor-mediated endocytosis;GO:0048639|positive regulation of developmental growth;GO:0050766|positive regulation of phagocytosis;GO:0051384|response to glucocorticoid;GO:0060041|retina development in camera-type eye;GO:0060100|positive regulation of phagocytosis, engulfment;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0097242|amyloid-beta clearance;GO:0097278|complement-dependent cytotoxicity;GO:0150062|complement-mediated synapse pruning;GO:0150064|vertebrate eye-specific patterning;GO:1901555|response to paclitaxel;GO:1905114|cell surface receptor signaling pathway involved in cell-cell signaling;GO:2000427|positive regulation of apoptotic cell clearance;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0009986|cell surface;GO:0032991|protein-containing complex;","GO:0004866|endopeptidase inhibitor activity;GO:0005515|protein binding;GO:0008289|lipid binding;GO:0031715|C5L2 anaphylatoxin chemotactic receptor binding;","K03990","C3; complement component 3"]
["ENSRNOG00000030530",445,36.94686393,10,0.643304382,57.43294306,5.843806587,{"v":5.3188e-122,"d":"5.32E-122"},{"v":1.1647E-120,"d":"1.16E-120"},"up","yes","Gzmm","protein_coding","chr7:10011066-10016665:-","gi|158262012|ref|NP_476531.1|",1345,0,"granzyme M precursor [Rattus norvegicus]","gi|298885451|emb|FQ233430.1|",955,0,"Rattus norvegicus TL0AEA61YO04 mRNA sequence","Q03238",511,0,"Granzyme M (Fragment)","VC1200",75.5,{"v":2E-14,"d":"2.00E-14"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0001913|T cell mediated cytotoxicity;GO:0006508|proteolysis;GO:0006915|apoptotic process;GO:0008150|biological_process;GO:0008219|cell death;GO:0019835|cytolysis;GO:0045087|innate immune response;","GO:0005575|cellular_component;GO:0005576|extracellular region;","GO:0004175|endopeptidase activity;GO:0004252|serine-type endopeptidase activity;GO:0008236|serine-type peptidase activity;","K08649","GZMM; granzyme M [EC:3.4.21.-]"]
["ENSRNOG00000024931",606,50.31415628,93,5.982730751,8.40989815,3.072088329,{"v":5.0693E-120,"d":"5.07E-120"},{"v":1.0988e-118,"d":"1.10E-118"},"up","yes","Ccdc88b","protein_coding","chr1:204036918-204052970:-","gi|109463441|ref|XP_001072042.1|",5985,0,"PREDICTED: coiled-coil domain-containing protein 88B [Rattus norvegicus]","gi|672014616|ref|XM_001072042.4|",4908,0,"PREDICTED: Rattus norvegicus coiled-coil domain containing 88B (Ccdc88b), mRNA","Q4QRL3",2004,0,"Coiled-coil domain-containing protein 88B",".",".",".",".","pfam05622","HOOK","HOOK protein. This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organisms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas the central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head.","GO:0001819|positive regulation of cytokine production;GO:0030705|cytoskeleton-dependent intracellular transport;GO:0031122|cytoplasmic microtubule organization;GO:0042102|positive regulation of T cell proliferation;GO:0042832|defense response to protozoan;GO:0050870|positive regulation of T cell activation;","GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0016020|membrane;","GO:0008017|microtubule binding;GO:0051959|dynein light intermediate chain binding;",".","."]
["ENSRNOG00000060381",1001,83.10968719,332,21.35770548,3.89132097,1.960259984,{"v":1.0839E-118,"d":"1.08E-118"},{"v":2.3257e-117,"d":"2.33E-117"},"up","yes","Col15a1","protein_coding","chr5:61501963-61607591:+","gi|407228400|ref|NP_001094005.1|",4836,0,"collagen alpha-1(XV) chain precursor [Rattus norvegicus]","gi|672052583|ref|XM_003749933.3|",5190,0,"PREDICTED: Rattus norvegicus collagen alpha-1(XV) chain-like (LOC100909752), mRNA","O35206",1653,0,"Collagen alpha-1(XV) chain",".",".",".",".","pfam06482","Endostatin","Collagenase NC10 and Endostatin. NC10 stands for Non-helical region 10 and is taken from human COL15A1. A mutation in this region in human COL18A1 is associated with an increased risk of prostrate cancer. This domain is cleaved from the precursor and forms endostatin. Endostatin is a key tumor suppressor and has been used highly successfully to treat cancer. It is a potent angiogenesis inhibitor. Endostatin also binds a zinc ion near the N-terminus; this is likely to be of structural rather than functional importance.","GO:0001525|angiogenesis;GO:0001886|endothelial cell morphogenesis;GO:0030198|extracellular matrix organization;","GO:0005581|collagen trimer;GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0031012|extracellular matrix;","GO:0005201|extracellular matrix structural constituent;","K08135","COL15A; collagen type XV alpha"]
["ENSRNOG00000027008",1042,86.51378027,361,23.22328818,3.72530279,1.897357692,{"v":2.6164e-118,"d":"2.62E-118"},{"v":5.5765e-117,"d":"5.58E-117"},"up","yes","Igtp","protein_coding","chr10:42357400-42408247:+","gi|32527749|gb|AAP86276.1|",6541,0,"Ac2-233 [Rattus norvegicus]","gi|32527748|gb|AY321344.1|",2775,0,"Rattus norvegicus Ac2-233 mRNA, complete cds","Q3T9E4",397,{"v":3e-123,"d":"3.00E-123"},"T-cell-specific guanine nucleotide triphosphate-binding protein 2",".",".",".",".","pfam05049","IIGP","Interferon-inducible GTPase (IIGP). Interferon-inducible GTPase (IIGP) is thought to play a role in in intracellular defence. IIGP is predominantly associated with the Golgi apparatus and also localizes to the endoplasmic reticulum and exerts a distinct role in IFN-induced intracellular membrane trafficking or processing.","GO:0006952|defense response;GO:0035458|cellular response to interferon-beta;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0003924|GTPase activity;GO:0005525|GTP binding;","K14140","IGTP; interferon gamma induced GTPase"]
["ENSRNOG00000021724",440,36.53173063,20,1.286608764,28.39381455,4.827504775,{"v":3.6985e-117,"d":"3.70E-117"},{"v":7.7282e-116,"d":"7.73E-116"},"up","yes","Ptprcap","protein_coding","chr1:201449113-201451288:+","gi|66730347|ref|NP_001019460.1|",705,{"v":8E-90,"d":"8.00E-90"},"protein tyrosine phosphatase receptor type C-associated protein precursor [Rattus norvegicus]","gi|298910651|emb|FQ225639.1|",851,0,"Rattus norvegicus TL0AEA4YF15 mRNA sequence","Q64697",200,{"v":9e-62,"d":"9.00E-62"},"Protein tyrosine phosphatase receptor type C-associated protein",".",".",".",".","pfam15258","FAM222A","Protein family of FAM222A. This protein family, FAM222A are a domain of unknown function. This family of proteins is found in eukaryotes and are typically between 411 and 562 amino acids in length. In humans, the gene encoding this protein domain lies in the position, chromosome 12 open reading frame 34.",".","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000069208",438,36.36567731,5,0.321652191,113.059007,6.820932121,{"v":1.0935E-116,"d":"1.09E-116"},{"v":2.2702e-115,"d":"2.27E-115"},"up","yes","ENSRNOG00000069208","pseudogene","chr3:2233522-2234359:-","gi|672034032|ref|XP_008756887.1|",577,{"v":1e-69,"d":"1.00E-69"},"PREDICTED: serine/arginine repetitive matrix protein 1-like [Rattus norvegicus]","gi|374429560|ref|NR_046239.1|",674,0,"Rattus norvegicus 45S pre-ribosomal RNA (Rn45s), ribosomal RNA",".",".",".",".",".",".",".",".","pfam07420","DUF1509","Protein of unknown function (DUF1509). This family consists of several uncharacterized viral proteins from the Marek's disease-like viruses. Members of this family are typically around 400 residues in length. The function of this family is unknown.",".",".",".",".","."]
["ENSRNOG00000000137",488,40.51701034,43,2.766208842,14.64712632,3.872545739,{"v":1.9704e-116,"d":"1.97E-116"},{"v":4.0772e-115,"d":"4.08E-115"},"up","yes","Ly86","protein_coding","chr17:27415830-27487260:-","gi|157821741|ref|NP_001099598.1|",867,{"v":6e-114,"d":"6.00E-114"},"lymphocyte antigen 86 [Rattus norvegicus]","gi|672081470|ref|XM_006253800.2|",936,0,"PREDICTED: Rattus norvegicus lymphocyte antigen 86 (Ly86), transcript variant X1, mRNA","O88188",265,{"v":5e-87,"d":"5.00E-87"},"Lymphocyte antigen 86",".",".",".",".","pfam02221","E1_DerP2_DerF2","ML domain. ML domain - MD-2-related lipid recognition domain. This family consists of proteins from plants, animals and fungi, including dust mite allergen Der P 2. It has been implicate in lipid recognition, particularly in the recognition of pathogen related products. A mutation in Npc2 causes a rare form of Niemann-Pick type C2 disease. This domain has a similar topology to immunoglobulin domains.","GO:0031666|positive regulation of lipopolysaccharide-mediated signaling pathway;GO:0045087|innate immune response;",".",".",".","."]
["ENSRNOG00000008837",1090,90.49905997,401,25.79650571,3.508190643,1.810727149,{"v":3.4613E-116,"d":"3.46E-116"},{"v":7.0935e-115,"d":"7.09E-115"},"up","yes","Ass1","protein_coding","chr3:14747368-14796903:+","gi|795329564|ref|XP_011826543.1|",2173,0,"PREDICTED: argininosuccinate synthase isoform X2 [Mandrillus leucophaeus]","gi|672044859|ref|XM_006233911.2|",1651,0,"PREDICTED: Rattus norvegicus argininosuccinate synthase 1 (Ass1), transcript variant X1, mRNA","P09034",834,0,"Argininosuccinate synthase","TM1780",479,{"v":2e-164,"d":"2.00E-164"},"COG0137","pfam00764","Arginosuc_synth","Arginosuccinate synthase. This family contains a PP-loop motif.","GO:0000050|urea cycle;GO:0000052|citrulline metabolic process;GO:0000053|argininosuccinate metabolic process;GO:0001822|kidney development;GO:0001889|liver development;GO:0006526|arginine biosynthetic process;GO:0006531|aspartate metabolic process;GO:0006953|acute-phase response;GO:0007494|midgut development;GO:0007568|aging;GO:0007584|response to nutrient;GO:0007623|circadian rhythm;GO:0009410|response to xenobiotic stimulus;GO:0009636|response to toxic substance;GO:0010043|response to zinc ion;GO:0010046|response to mycotoxin;GO:0014075|response to amine;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0043200|response to amino acid;GO:0043434|response to peptide hormone;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0048545|response to steroid hormone;GO:0051384|response to glucocorticoid;GO:0060416|response to growth hormone;GO:0060539|diaphragm development;GO:0070542|response to fatty acid;GO:0071222|cellular response to lipopolysaccharide;GO:0071230|cellular response to amino acid stimulus;GO:0071242|cellular response to ammonium ion;GO:0071320|cellular response to cAMP;GO:0071346|cellular response to interferon-gamma;GO:0071356|cellular response to tumor necrosis factor;GO:0071377|cellular response to glucagon stimulus;GO:0071400|cellular response to oleic acid;GO:0071418|cellular response to amine stimulus;GO:0071499|cellular response to laminar fluid shear stress;GO:0071549|cellular response to dexamethasone stimulus;GO:1903038|negative regulation of leukocyte cell-cell adhesion;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0005764|lysosome;GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0070852|cell body fiber;","GO:0004055|argininosuccinate synthase activity;GO:0005524|ATP binding;GO:0015643|toxic substance binding;GO:0016597|amino acid binding;GO:0042802|identical protein binding;","K01940","argG, ASS1; argininosuccinate synthase [EC:6.3.4.5]"]
["ENSRNOG00000026647",1324,109.9272985,574,36.92567152,2.976988475,1.573853636,{"v":9.4183e-116,"d":"9.42E-116"},{"v":1.924e-114,"d":"1.92E-114"},"up","yes","Cxcl16","protein_coding","chr10:55166723-55171592:-","gi|62945312|ref|NP_001017478.1|",1018,{"v":2e-130,"d":"2.00E-130"},"C-X-C motif chemokine 16 precursor [Rattus norvegicus]","gi|65993504|gb|DQ025528.1|",1255,0,"Rattus norvegicus CXCL16 (Cxcl16) mRNA, complete cds","Q6AXU5",396,{"v":5e-132,"d":"5.00E-132"},"C-X-C motif chemokine 16",".",".",".",".","pfam15455","Pro-rich_19","Proline-rich 19. This family includes proline-rich protein 19.","GO:0006898|receptor-mediated endocytosis;GO:0007165|signal transduction;GO:0010818|T cell chemotaxis;GO:0030307|positive regulation of cell growth;GO:0030335|positive regulation of cell migration;GO:0034097|response to cytokine;GO:0034341|response to interferon-gamma;GO:0034612|response to tumor necrosis factor;GO:0071222|cellular response to lipopolysaccharide;","GO:0005615|extracellular space;GO:0016021|integral component of membrane;","GO:0005041|low-density lipoprotein particle receptor activity;GO:0005044|scavenger receptor activity;GO:0008009|chemokine activity;GO:0042379|chemokine receptor binding;","K10035","CXCL16; C-X-C motif chemokine 16"]
["ENSRNOG00000001224",689,57.2053691,146,9.392243975,6.090703058,2.60660877,{"v":1.6283e-115,"d":"1.63E-115"},{"v":3.3053e-114,"d":"3.31E-114"},"up","yes","Itgb2","protein_coding","chr20:11061430-11097600:-","gi|163937849|ref|NP_001032869.2|",3677,0,"integrin beta-2 precursor [Rattus norvegicus]","gi|163937848|ref|NM_001037780.2|",3151,0,"Rattus norvegicus integrin, beta 2 (Itgb2), mRNA","P11835",1291,0,"Integrin beta-2",".",".",".",".","pfam00362","Integrin_beta","Integrin, beta chain. Integrins have been found in animals and their homologues have also been found in cyanobacteria, probably due to horizontal gene transfer. The sequences repeats have been trimmed due to an overlap with EGF.","GO:0002523|leukocyte migration involved in inflammatory response;GO:0006898|receptor-mediated endocytosis;GO:0006911|phagocytosis, engulfment;GO:0007155|cell adhesion;GO:0007159|leukocyte cell-cell adhesion;GO:0007160|cell-matrix adhesion;GO:0007229|integrin-mediated signaling pathway;GO:0007568|aging;GO:0016477|cell migration;GO:0030101|natural killer cell activation;GO:0030593|neutrophil chemotaxis;GO:0031623|receptor internalization;GO:0032930|positive regulation of superoxide anion generation;GO:0033627|cell adhesion mediated by integrin;GO:0034113|heterotypic cell-cell adhesion;GO:0035987|endodermal cell differentiation;GO:0043113|receptor clustering;GO:0043315|positive regulation of neutrophil degranulation;GO:0043542|endothelial cell migration;GO:0045123|cellular extravasation;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0045766|positive regulation of angiogenesis;GO:0050730|regulation of peptidyl-tyrosine phosphorylation;GO:0050766|positive regulation of phagocytosis;GO:0050798|activated T cell proliferation;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0071404|cellular response to low-density lipoprotein particle stimulus;GO:0097242|amyloid-beta clearance;GO:0098609|cell-cell adhesion;GO:1904996|positive regulation of leukocyte adhesion to vascular endothelial cell;GO:1990266|neutrophil migration;","GO:0005886|plasma membrane;GO:0005925|focal adhesion;GO:0008305|integrin complex;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0034687|integrin alphaL-beta2 complex;GO:0034688|integrin alphaM-beta2 complex;GO:0043235|receptor complex;GO:0044853|plasma membrane raft;GO:0045121|membrane raft;","GO:0001540|amyloid-beta binding;GO:0001851|complement component C3b binding;GO:0005178|integrin binding;GO:0019901|protein kinase binding;GO:0030369|ICAM-3 receptor activity;GO:0031072|heat shock protein binding;GO:0038024|cargo receptor activity;GO:0044877|protein-containing complex binding;GO:0046872|metal ion binding;GO:0050839|cell adhesion molecule binding;","K06464","ITGB2, CD18; integrin beta 2"]
["ENSRNOG00000015736",1587,131.7633103,787,50.62805485,2.602575008,1.379939744,{"v":4.1596e-114,"d":"4.16E-114"},{"v":8.3903e-113,"d":"8.39E-113"},"up","yes","Dhrs3","protein_coding","chr5:156747962-156782417:+","gi|148747124|ref|NP_001032276.3|",1610,0,"short-chain dehydrogenase/reductase 3 [Rattus norvegicus]","gi|119434399|gb|EF125189.1|",2039,0,"Rattus norvegicus retinal dehydrogenase/reductase family member 3 mRNA, complete cds","O88876",621,0,"Short-chain dehydrogenase/reductase 3","MA2687",100,{"v":2e-22,"d":"2.00E-22"},"COG1028","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.","GO:0001523|retinoid metabolic process;GO:0003151|outflow tract morphogenesis;GO:0030278|regulation of ossification;GO:0042572|retinol metabolic process;GO:0048385|regulation of retinoic acid receptor signaling pathway;GO:0048387|negative regulation of retinoic acid receptor signaling pathway;GO:0060021|roof of mouth development;GO:0060349|bone morphogenesis;GO:0060411|cardiac septum morphogenesis;","GO:0005811|lipid droplet;GO:0016021|integral component of membrane;","GO:0004745|retinol dehydrogenase activity;GO:0016616|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;","K11146","DHRS3; short-chain dehydrogenase/reductase 3 [EC:1.1.1.300]"]
["ENSRNOG00000038881",652,54.13338266,132,8.49161784,6.374919795,2.672407191,{"v":2.306e-112,"d":"2.31E-112"},{"v":4.565E-111,"d":"4.57E-111"},"up","yes","Hcls1","protein_coding","chr11:63817476-63841014:-","gi|58865374|ref|NP_001011898.1|",1858,0,"hematopoietic lineage cell-specific protein [Rattus norvegicus]","gi|58865373|ref|NM_001011898.1|",1914,0,"Rattus norvegicus hematopoietic cell specific Lyn substrate 1 (Hcls1), mRNA","P49710",675,0,"Hematopoietic lineage cell-specific protein",".",".",".",".","pfam02218","HS1_rep","Repeat in HS1/Cortactin. The function of this repeat is unknown. Seven copies are found in cortactin and four copies are found in HS1. The repeats are always found amino terminal to an SH3 domain pfam00018.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0008284|positive regulation of cell proliferation;GO:0009725|response to hormone;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0030041|actin filament polymerization;GO:0030218|erythrocyte differentiation;GO:0030833|regulation of actin filament polymerization;GO:0030854|positive regulation of granulocyte differentiation;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0042307|positive regulation of protein import into nucleus;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0045651|positive regulation of macrophage differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051897|positive regulation of protein kinase B signaling;GO:0071345|cellular response to cytokine stimulus;GO:2000107|negative regulation of leukocyte apoptotic process;","GO:0005634|nucleus;GO:0005667|transcription factor complex;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0030427|site of polarized growth;GO:0030864|cortical actin cytoskeleton;","GO:0017124|SH3 domain binding;GO:0019901|protein kinase binding;GO:0044877|protein-containing complex binding;GO:0051015|actin filament binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;","K06106","CTTN, EMS1; cortactin"]
["ENSRNOG00000032240",493,40.93214364,53,3.409513224,12.00527493,3.585596538,{"v":1.8118e-111,"d":"1.81E-111"},{"v":3.5427e-110,"d":"3.54E-110"},"up","yes","Gbp5","protein_coding","chr2:231237748-231257061:+","gi|166091462|ref|NP_001102039.2|",2598,0,"guanylate-binding protein 5 [Rattus norvegicus]","gi|214010143|ref|NM_001108569.3|",2759,0,"Rattus norvegicus guanylate binding protein 5 (Gbp5), mRNA","Q8CFB4",828,0,"Guanylate-binding protein 5",".",".",".",".","pfam02263","GBP","Guanylate-binding protein, N-terminal domain. Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.","GO:0009617|response to bacterium;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032741|positive regulation of interleukin-18 production;GO:0034067|protein localization to Golgi apparatus;GO:0045089|positive regulation of innate immune response;GO:0051289|protein homotetramerization;GO:0071346|cellular response to interferon-gamma;GO:1900017|positive regulation of cytokine production involved in inflammatory response;GO:1900227|positive regulation of NLRP3 inflammasome complex assembly;","GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0031410|cytoplasmic vesicle;GO:0048471|perinuclear region of cytoplasm;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;","K20898","GBP5; guanylate-binding protein 5"]
["ENSRNOG00000037113",2151,178.5903468,1281,82.40729131,2.167166812,1.115810205,{"v":7.1102e-111,"d":"7.11E-111"},{"v":1.3819E-109,"d":"1.38E-109"},"up","yes","Slfn2","protein_coding","chr10:67953171-67959458:+","gi|157823357|ref|NP_001100501.1|",1802,0,"schlafen family member 12-like [Rattus norvegicus]","gi|157823356|ref|NM_001107031.1|",1635,0,"Rattus norvegicus schlafen 2 (Slfn2), mRNA","Q5RCZ8",375,{"v":1e-115,"d":"1.00E-115"},"Schlafen family member 12-like",".",".",".",".","pfam04326","AAA_4","Divergent AAA domain. This family is related to the pfam00004 family, and presumably has the same function (ATP-binding).","GO:0008285|negative regulation of cell proliferation;GO:0009617|response to bacterium;",".",".","K24457","SLFN12, SLFN12L; schlafen family member 12"]
["ENSRNOG00000061739",407,33.79185083,6,0.385982629,87.54759485,6.45199564,{"v":2.3371e-110,"d":"2.34E-110"},{"v":4.5147e-109,"d":"4.51E-109"},"up","yes","Klrk1","protein_coding","chr4:163081927-163092459:-","gi|564348312|ref|XP_006237135.1|",1238,{"v":5e-162,"d":"5.00E-162"},"PREDICTED: NKG2-D type II integral membrane protein isoform X2 [Rattus norvegicus]","gi|672051172|ref|XM_006237073.2|",2340,0,"PREDICTED: Rattus norvegicus killer cell lectin-like receptor subfamily K, member 1 (Klrk1), transcript variant X1, mRNA","O70215",450,{"v":1e-151,"d":"1.00E-151"},"NKG2-D type II integral membrane protein",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0002223|stimulatory C-type lectin receptor signaling pathway;GO:0002250|adaptive immune response;GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target;GO:0030101|natural killer cell activation;GO:0030154|cell differentiation;GO:0030887|positive regulation of myeloid dendritic cell activation;GO:0032729|positive regulation of interferon-gamma production;GO:0034260|negative regulation of GTPase activity;GO:0042267|natural killer cell mediated cytotoxicity;GO:0043065|positive regulation of apoptotic process;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;GO:0050830|defense response to Gram-positive bacterium;GO:0071222|cellular response to lipopolysaccharide;GO:2000502|negative regulation of natural killer cell chemotaxis;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0005515|protein binding;GO:0019900|kinase binding;GO:0030246|carbohydrate binding;GO:0032394|MHC class Ib receptor activity;GO:0038023|signaling receptor activity;GO:0042288|MHC class I protein binding;GO:0042802|identical protein binding;","K06728","KLRK1, CD314; killer cell lectin-like receptor subfamily K member 1"]
["ENSRNOG00000038999",1140,94.650393,460,29.59200157,3.198512706,1.677401214,{"v":2.4872e-109,"d":"2.49E-109"},{"v":4.7902e-108,"d":"4.79E-108"},"up","yes","RT1-CE11","protein_coding","chr20:3350937-3380362:-","gi|57012420|ref|NP_001008833.1|",1581,0,"RT1 class I, locus CE10 precursor [Rattus norvegicus]","gi|46237620|emb|BX883046.1|",3470,0,"Rattus norvegicus chromosome 20, major histocompatibility complex, assembled from 40 BACs, strain Brown Norway (BN/ssNHsd), RT1n haplotype; segment 5/11","P16391",544,{"v":7e-178,"d":"7.00E-178"},"RT1 class I histocompatibility antigen, AA alpha chain",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.","GO:0001916|positive regulation of T cell mediated cytotoxicity;GO:0002476|antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002486|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0002517|T cell tolerance induction;GO:0002657|positive regulation of tolerance induction to nonself antigen;GO:0006955|immune response;GO:0045953|negative regulation of natural killer cell mediated cytotoxicity;","GO:0005615|extracellular space;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0005102|signaling receptor binding;GO:0005515|protein binding;GO:0030881|beta-2-microglobulin binding;GO:0042277|peptide binding;GO:0042605|peptide antigen binding;GO:0044877|protein-containing complex binding;","K06751","MHC1; MHC class I antigen"]
["ENSRNOG00000001480",677,56.20904918,154,9.90688748,5.673734489,2.504298639,{"v":1.1455E-108,"d":"1.15E-108"},{"v":2.1799e-107,"d":"2.18E-107"},"up","yes","Ncf1","protein_coding","chr12:22485451-22494646:+","gi|939204643|sp|F1M707.2|NCF1_RAT",2003,0,"RecName: Full=Neutrophil cytosolic factor 1; Short=NCF-1","gi|40254741|ref|NM_053734.2|",2751,0,"Rattus norvegicus neutrophil cytosolic factor 1 (Ncf1), mRNA","F1M707",776,0,"Neutrophil cytosolic factor 1",".",".",".",".","pfam00787","PX","PX domain. PX domains bind to phosphoinositides.","GO:0001878|response to yeast;GO:0001909|leukocyte mediated cytotoxicity;GO:0002679|respiratory burst involved in defense response;GO:0006612|protein targeting to membrane;GO:0006691|leukotriene metabolic process;GO:0006915|apoptotic process;GO:0006954|inflammatory response;GO:0006968|cellular defense response;GO:0008283|cell proliferation;GO:0009617|response to bacterium;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0034614|cellular response to reactive oxygen species;GO:0042554|superoxide anion generation;GO:0042742|defense response to bacterium;GO:0045730|respiratory burst;GO:0045741|positive regulation of epidermal growth factor-activated receptor activity;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045986|negative regulation of smooth muscle contraction;GO:0046330|positive regulation of JNK cascade;GO:0050665|hydrogen peroxide biosynthetic process;GO:0050790|regulation of catalytic activity;GO:0050830|defense response to Gram-positive bacterium;GO:0050832|defense response to fungus;GO:0060264|regulation of respiratory burst involved in inflammatory response;GO:0070946|neutrophil mediated killing of gram-positive bacterium;GO:0070947|neutrophil mediated killing of fungus;GO:0071276|cellular response to cadmium ion;GO:1900745|positive regulation of p38MAPK cascade;GO:1903409|reactive oxygen species biosynthetic process;","GO:0005737|cytoplasm;GO:0005791|rough endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0019898|extrinsic component of membrane;GO:0030425|dendrite;GO:0043020|NADPH oxidase complex;GO:0043025|neuronal cell body;","GO:0016175|superoxide-generating NADPH oxidase activity;GO:0016176|superoxide-generating NADPH oxidase activator activity;GO:0017124|SH3 domain binding;GO:0035091|phosphatidylinositol binding;GO:0043325|phosphatidylinositol-3,4-bisphosphate binding;","K08011","NCF1, P47PHOX; neutrophil cytosolic factor 1"]
["ENSRNOG00000006384",799,66.33830176,230,14.79600078,4.483529214,2.164634798,{"v":8.3118e-108,"d":"8.31E-108"},{"v":1.5677e-106,"d":"1.57E-106"},"up","yes","Ddx58","protein_coding","chr5:55321235-55370819:-","gi|153945886|ref|NP_766277.3|",4148,0,"probable ATP-dependent RNA helicase DDX58 [Mus musculus]","gi|153945885|ref|NM_172689.3|",2198,0,"Mus musculus DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (Ddx58), mRNA","Q6Q899",1602,0,"Probable ATP-dependent RNA helicase DDX58","PAB0190_1",131,{"v":6e-31,"d":"6.00E-31"},"COG1111","pfam11648","RIG-I_C-RD","C-terminal domain of RIG-I. This family of proteins represents the regulatory domain RD of RIG-I, a protein which initiates a signalling cascade that provides essential antiviral protection for the host. The RD domain binds viral RNA, activating the RIG-I ATPase by RNA-dependant dimerization. The structure of RD contains a zinc-binding domain and is thought to confer ligand specificity.","GO:0002230|positive regulation of defense response to virus by host;GO:0002735|positive regulation of myeloid dendritic cell cytokine production;GO:0009597|detection of virus;GO:0009615|response to virus;GO:0010628|positive regulation of gene expression;GO:0030334|regulation of cell migration;GO:0032725|positive regulation of granulocyte macrophage colony-stimulating factor production;GO:0032727|positive regulation of interferon-alpha production;GO:0032728|positive regulation of interferon-beta production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0039529|RIG-I signaling pathway;GO:0043330|response to exogenous dsRNA;GO:0045087|innate immune response;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051607|defense response to virus;GO:0060760|positive regulation of response to cytokine stimulus;GO:0071360|cellular response to exogenous dsRNA;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005923|bicellular tight junction;GO:0015629|actin cytoskeleton;GO:0032587|ruffle membrane;GO:1990904|ribonucleoprotein complex;","GO:0003690|double-stranded DNA binding;GO:0003725|double-stranded RNA binding;GO:0003727|single-stranded RNA binding;GO:0005524|ATP binding;GO:0008270|zinc ion binding;GO:0016787|hydrolase activity;GO:0031625|ubiquitin protein ligase binding;GO:0042802|identical protein binding;","K12646","DDX58, RIG-I; ATP-dependent RNA helicase DDX58 [EC:3.6.4.13]"]
["ENSRNOG00000057443",863,71.65200803,274,17.62654006,4.06500696,2.023257822,{"v":7.4344e-107,"d":"7.43E-107"},{"v":1.3819E-105,"d":"1.38E-105"},"up","yes","Nos2","protein_coding","chr10:63815308-63851210:+","gi|564373342|ref|XP_006247011.1|",6175,0,"PREDICTED: nitric oxide synthase, inducible-like [Rattus norvegicus]","gi|430718|gb|U03699.1|RNU03699",3784,0,"Rattus norvegicus Sprague Dawley inducible nitric oxide synthase (NOS) mRNA, complete cds","Q06518",2306,0,"Nitric oxide synthase, inducible","BH0823",346,{"v":1e-106,"d":"1.00E-106"},"COG4362","pfam02898","NO_synthase","Nitric oxide synthase, oxygenase domain.","GO:0001666|response to hypoxia;GO:0001935|endothelial cell proliferation;GO:0001974|blood vessel remodeling;GO:0006527|arginine catabolic process;GO:0006801|superoxide metabolic process;GO:0006809|nitric oxide biosynthetic process;GO:0006954|inflammatory response;GO:0007165|signal transduction;GO:0007199|G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger;GO:0007263|nitric oxide mediated signal transduction;GO:0007568|aging;GO:0007623|circadian rhythm;GO:0008016|regulation of heart contraction;GO:0008217|regulation of blood pressure;GO:0009612|response to mechanical stimulus;GO:0009617|response to bacterium;GO:0009725|response to hormone;GO:0010629|negative regulation of gene expression;GO:0014823|response to activity;GO:0016137|glycoside metabolic process;GO:0018119|peptidyl-cysteine S-nitrosylation;GO:0019934|cGMP-mediated signaling;GO:0031284|positive regulation of guanylate cyclase activity;GO:0032310|prostaglandin secretion;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0034612|response to tumor necrosis factor;GO:0035556|intracellular signal transduction;GO:0035902|response to immobilization stress;GO:0042060|wound healing;GO:0042127|regulation of cell proliferation;GO:0042177|negative regulation of protein catabolic process;GO:0042742|defense response to bacterium;GO:0043065|positive regulation of apoptotic process;GO:0045776|negative regulation of blood pressure;GO:0048384|retinoic acid receptor signaling pathway;GO:0050796|regulation of insulin secretion;GO:0050829|defense response to Gram-negative bacterium;GO:0051712|positive regulation of killing of cells of other organism;GO:0071222|cellular response to lipopolysaccharide;GO:0071285|cellular response to lithium ion;GO:0071305|cellular response to vitamin D;GO:0071345|cellular response to cytokine stimulus;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071407|cellular response to organic cyclic compound;GO:0071461|cellular response to redox state;GO:0071466|cellular response to xenobiotic stimulus;GO:0071548|response to dexamethasone;GO:1900015|regulation of cytokine production involved in inflammatory response;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005777|peroxisome;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0012506|vesicle membrane;GO:0030863|cortical cytoskeleton;GO:0048471|perinuclear region of cytoplasm;","GO:0003779|actin binding;GO:0004517|nitric-oxide synthase activity;GO:0005515|protein binding;GO:0005516|calmodulin binding;GO:0008013|beta-catenin binding;GO:0008603|cAMP-dependent protein kinase regulator activity;GO:0010181|FMN binding;GO:0016491|oxidoreductase activity;GO:0019901|protein kinase binding;GO:0020037|heme binding;GO:0034617|tetrahydrobiopterin binding;GO:0034618|arginine binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0045296|cadherin binding;GO:0046872|metal ion binding;GO:0050660|flavin adenine dinucleotide binding;GO:0050661|NADP binding;GO:0050998|nitric-oxide synthase binding;GO:0051879|Hsp90 protein binding;","K13241","NOS2; nitric-oxide synthase, inducible [EC:1.14.13.39]"]
["ENSRNOG00000009919",618,51.3104762,0,0.032165219,1595.216126,10.63953618,{"v":8.1869e-107,"d":"8.19E-107"},{"v":1.5173E-105,"d":"1.52E-105"},"up","yes","Acod1","protein_coding","chr15:79871827-79880529:+","gi|157822797|ref|NP_001100752.1|",2508,0,"cis-aconitate decarboxylase [Rattus norvegicus]","gi|157822796|ref|NM_001107282.1|",2124,0,"Rattus norvegicus immunoresponsive gene 1 (Irg1), mRNA","P54987",909,0,"Cis-aconitate decarboxylase","PA0881",96.7,{"v":3e-20,"d":"3.00E-20"},"COG2079","pfam03972","MmgE_PrpD","MmgE/PrpD family. This family includes 2-methylcitrate dehydratase EC:4.2.1.79 (PrpD) that is required for propionate catabolism. It catalyses the third step of the 2-methylcitric acid cycle.","GO:0002760|positive regulation of antimicrobial humoral response;GO:0006952|defense response;GO:0007566|embryo implantation;GO:0009617|response to bacterium;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0032480|negative regulation of type I interferon production;GO:0032496|response to lipopolysaccharide;GO:0034136|negative regulation of toll-like receptor 2 signaling pathway;GO:0034144|negative regulation of toll-like receptor 4 signaling pathway;GO:0035458|cellular response to interferon-beta;GO:0045824|negative regulation of innate immune response;GO:0050728|negative regulation of inflammatory response;GO:0051607|defense response to virus;GO:0071219|cellular response to molecule of bacterial origin;GO:0071222|cellular response to lipopolysaccharide;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071393|cellular response to progesterone stimulus;GO:0072573|tolerance induction to lipopolysaccharide;GO:2000379|positive regulation of reactive oxygen species metabolic process;","GO:0005739|mitochondrion;","GO:0047613|aconitate decarboxylase activity;","K17724","IRG1; aconitate decarboxylase [EC:4.1.1.6]"]
["ENSRNOG00000031081",1453,120.6377377,714,45.93193286,2.626445922,1.39311188,{"v":3.9479e-106,"d":"3.95E-106"},{"v":7.2331e-105,"d":"7.23E-105"},"up","yes","Stat2","protein_coding","chr7:702495-718967:+","gi|58865380|ref|NP_001011905.1|",3913,0,"signal transducer and activator of transcription 2 [Rattus norvegicus]","gi|672057475|ref|XM_006240747.2|",1977,0,"PREDICTED: Rattus norvegicus signal transducer and activator of transcription 2 (Stat2), transcript variant X1, mRNA","Q9WVL2",1154,0,"Signal transducer and activator of transcription 2",".",".",".",".","pfam02864","STAT_bind","STAT protein, DNA binding domain. STAT proteins (Signal Transducers and Activators of Transcription) are a family of transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors. This family represents the DNA binding domain of STAT, which has an ig-like fold. STAT proteins also include an SH2 domain pfam00017.","GO:0001932|regulation of protein phosphorylation;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006952|defense response;GO:0007259|JAK-STAT cascade;GO:0008150|biological_process;GO:0019221|cytokine-mediated signaling pathway;GO:0042127|regulation of cell proliferation;GO:0043434|response to peptide hormone;GO:0051607|defense response to virus;GO:0060337|type I interferon signaling pathway;GO:0060339|negative regulation of type I interferon-mediated signaling pathway;GO:0090140|regulation of mitochondrial fission;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0042802|identical protein binding;GO:0044389|ubiquitin-like protein ligase binding;","K11221","STAT2; signal transducer and activator of transcription 2"]
["ENSRNOG00000059140",555,46.07979659,94,6.047061189,7.620196844,2.929828266,{"v":2.8356E-105,"d":"2.84E-105"},{"v":5.1363e-104,"d":"5.14E-104"},"up","yes","Myo1g","protein_coding","chr14:81386701-81401843:-","gi|564384294|ref|XP_006251280.1|",5241,0,"PREDICTED: unconventional myosin-Ig isoform X1 [Rattus norvegicus]","gi|672076641|ref|XM_006251218.2|",3301,0,"PREDICTED: Rattus norvegicus myosin IG (Myo1g), transcript variant X1, mRNA","Q5SUA5",1971,0,"Unconventional myosin-Ig","YKL129c",498,{"v":2e-154,"d":"2.00E-154"},"COG5022","pfam00063","Myosin_head","Myosin head (motor domain).","GO:0002456|T cell mediated immunity;GO:0006887|exocytosis;GO:0006909|phagocytosis;GO:0031589|cell-substrate adhesion;GO:0038096|Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0071976|cell gliding;GO:0120117|T cell meandering migration;","GO:0001891|phagocytic cup;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0005902|microvillus;GO:0016459|myosin complex;GO:0030027|lamellipodium;GO:0030175|filopodium;GO:0031256|leading edge membrane;","GO:0005516|calmodulin binding;GO:0005524|ATP binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;GO:0043325|phosphatidylinositol-3,4-bisphosphate binding;","K10356","MYO1; myosin I"]
["ENSRNOG00000048222",721,59.86222224,190,12.22278326,4.89759337,2.292072997,{"v":2.0091E-104,"d":"2.01E-104"},{"v":3.5984e-103,"d":"3.60E-103"},"up","yes","Nlrc5","protein_coding","chr19:10477628-10562121:-","gi|293343229|ref|XP_001062196.2|",9158,0,"PREDICTED: protein NLRC5 isoform X1 [Rattus norvegicus]","gi|672031046|ref|XM_001062196.4|",7035,0,"PREDICTED: Rattus norvegicus NLR family, CARD domain containing 5 (Nlrc5), transcript variant X1, mRNA","C3VPR6",2578,0,"Protein NLRC5",".",".",".",".","pfam05729","NACHT","NACHT domain. This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.","GO:0009617|response to bacterium;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0043549|regulation of kinase activity;GO:0045087|innate immune response;GO:0045345|positive regulation of MHC class I biosynthetic process;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051607|defense response to virus;GO:0060335|positive regulation of interferon-gamma-mediated signaling pathway;GO:0060339|negative regulation of type I interferon-mediated signaling pathway;GO:0060340|positive regulation of type I interferon-mediated signaling pathway;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0005829|cytosol;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;","K22615","NLRC5, NOD4; NLR family CARD domain containing 5"]
["ENSRNOG00000022975",514,42.67570351,77,4.95344374,8.615360494,3.106911165,{"v":3.754e-103,"d":"3.75E-103"},{"v":6.6677E-102,"d":"6.67E-102"},"up","yes","Nfam1","protein_coding","chr7:114139345-114175442:-","gi|564309086|ref|XP_006226237.1|",1205,{"v":4e-155,"d":"4.00E-155"},"PREDICTED: NFAT activation molecule 1 isoform X1 [Rattus norvegicus]","gi|672022166|ref|XM_006226175.2|",2841,0,"PREDICTED: Rattus norvegicus NFAT activating protein with ITAM motif 1 (Nfam1), transcript variant X1, mRNA","Q8R4V1",284,{"v":1e-86,"d":"1.00E-86"},"NFAT activation molecule 1",".",".",".",".","pfam15068","FAM101","FAM101 family. This protein family includes the actin regulators, Refilin A and B, however the exact function of this protein family remains unknown. Refilin is thought to stabilize peri-nuclear actin filament bundles, important in fibroblasts. Refilin is important as changes in localisation and shape in the nucleus plays a role in cellular and developmental processes.","GO:0001819|positive regulation of cytokine production;GO:0007165|signal transduction;GO:0030183|B cell differentiation;GO:0035556|intracellular signal transduction;GO:0045577|regulation of B cell differentiation;GO:0050853|B cell receptor signaling pathway;GO:0050861|positive regulation of B cell receptor signaling pathway;GO:0051091|positive regulation of DNA-binding transcription factor activity;","GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0045121|membrane raft;","GO:0004888|transmembrane signaling receptor activity;",".","."]
["ENSRNOG00000063127",393,32.62947759,21,1.350939202,24.15317991,4.594141236,{"v":5.3866e-103,"d":"5.39E-103"},{"v":9.5144e-102,"d":"9.51E-102"},"up","yes","Ccr2","protein_coding","chr8:123734430-123742100:+","gi|11177914|ref|NP_068638.1|",1741,0,"C-C chemokine receptor type 2 [Rattus norvegicus]","gi|755532612|ref|XM_011243063.1|",2290,0,"PREDICTED: Mus musculus chemokine (C-C motif) receptor 2 (Ccr2), transcript variant X2, mRNA","O55193",675,0,"C-C chemokine receptor type 2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.",".",".",".",".","."]
["ENSRNOG00000042139",518,43.00781015,80,5.146435055,8.356815872,3.062953349,{"v":1.3515E-102,"d":"1.35E-102"},{"v":2.3676e-101,"d":"2.37E-101"},"up","yes","Clec4a1","protein_coding","chr4:156173894-156186008:+","gi|54312106|ref|NP_001005890.1|",1120,{"v":4E-150,"d":"4.00E-150"},"C-type lectin domain family 4, member A1 [Rattus norvegicus]","gi|70778852|ref|NM_001005890.2|",1199,0,"Rattus norvegicus C-type lectin domain family 4, member A1 (Clec4a1), mRNA","Q9UMR7",201,{"v":3e-60,"d":"3.00E-60"},"C-type lectin domain family 4 member A",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type",".","GO:0016021|integral component of membrane;","GO:0030246|carbohydrate binding;","K10057","CLEC4A, CD367; C-type lectin domain family 4 member A"]
["ENSRNOG00000013220",982,81.53218064,369,23.73793169,3.434679217,1.780175364,{"v":1.7491e-102,"d":"1.75E-102"},{"v":3.0558E-101,"d":"3.06E-101"},"up","yes","Arhgap45","protein_coding","chr7:9674897-9690268:-","gi|157820943|ref|NP_001101537.1|",5119,0,"minor histocompatibility protein HA-1 [Rattus norvegicus]","gi|157820942|ref|NM_001108067.1|",3883,0,"Rattus norvegicus histocompatibility (minor) HA-1 (Hmha1), mRNA","Q3TBD2",1873,0,"Rho GTPase-activating protein 45",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0035556|intracellular signal transduction;GO:0090630|activation of GTPase activity;",".","GO:0005096|GTPase activator activity;","K20644","ARHGAP29_45; Rho GTPase-activating protein 29/45"]
["ENSRNOG00000016308",542,45.00045,93,5.982730751,7.521724088,2.911063386,{"v":3.247E-102,"d":"3.25E-102"},{"v":5.6417e-101,"d":"5.64E-101"},"up","yes","Il10ra","protein_coding","chr8:45563137-45578061:-","gi|340523096|ref|NP_476541.2|",2900,0,"interleukin-10 receptor subunit alpha precursor [Rattus norvegicus]","gi|672061584|ref|XM_006242864.2|",3339,0,"PREDICTED: Rattus norvegicus interleukin 10 receptor, alpha (Il10ra), transcript variant X1, mRNA","Q61727",885,0,"Interleukin-10 receptor subunit alpha",".",".",".",".","pfam01108","Tissue_fac","Tissue factor. This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.","GO:0010507|negative regulation of autophagy;GO:0019221|cytokine-mediated signaling pathway;GO:0032496|response to lipopolysaccharide;GO:0046427|positive regulation of JAK-STAT cascade;GO:0050807|regulation of synapse organization;GO:0070086|ubiquitin-dependent endocytosis;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004896|cytokine receptor activity;GO:0004920|interleukin-10 receptor activity;GO:0019969|interleukin-10 binding;","K05134","IL10RA, CD210A; interleukin 10 receptor alpha"]
["ENSRNOG00000010018",601,49.89902298,126,8.105635211,6.156090383,2.622014413,{"v":1.1902e-101,"d":"1.19E-101"},{"v":2.0568e-100,"d":"2.06E-100"},"up","yes","Clec4a3","protein_coding","chr4:156214718-156224817:+","gi|564348867|ref|XP_006237383.1|",1076,{"v":3e-143,"d":"3.00E-143"},"PREDICTED: C-type lectin domain family 4, member A3 isoform X1 [Rattus norvegicus]","gi|672050888|ref|XM_006237321.2|",1264,0,"PREDICTED: Rattus norvegicus C-type lectin domain family 4, member A3 (Clec4a3), transcript variant X1, mRNA","Q9QZ15",235,{"v":5e-73,"d":"5.00E-73"},"C-type lectin domain family 4 member A",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0001818|negative regulation of cytokine production;GO:0002470|plasmacytoid dendritic cell antigen processing and presentation;GO:0032720|negative regulation of tumor necrosis factor production;GO:0036037|CD8-positive, alpha-beta T cell activation;GO:0042590|antigen processing and presentation of exogenous peptide antigen via MHC class I;","GO:0016021|integral component of membrane;","GO:0005509|calcium ion binding;GO:0005537|mannose binding;GO:0030246|carbohydrate binding;","K10057","CLEC4A, CD367; C-type lectin domain family 4 member A"]
["ENSRNOG00000000459",1236,102.6209524,562,36.15370626,2.838462858,1.505109864,{"v":1.8755e-101,"d":"1.88E-101"},{"v":3.2238e-100,"d":"3.22E-100"},"up","yes","Psmb9","protein_coding","chr20:4666046-4672512:+","gi|542130184|gb|AGV38985.1|",679,{"v":3e-81,"d":"3.00E-81"},"proteasome subunit beta type-9 [Rattus norvegicus]","gi|89214481|gb|AC120734.5|",1156,0,"Rattus norvegicus BAC CH230-220D1 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P28077",264,{"v":5e-82,"d":"5.00E-82"},"Proteasome subunit beta type-9",".",".",".",".","pfam00227","Proteasome","Proteasome subunit. The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria. The second is call beta-proteobacteria proteasome homologue (BPH).","GO:0001889|liver development;GO:0002376|immune system process;GO:0009410|response to xenobiotic stimulus;GO:0009617|response to bacterium;GO:0010498|proteasomal protein catabolic process;GO:0014889|muscle atrophy;GO:0019882|antigen processing and presentation;GO:0043279|response to alkaloid;GO:0048536|spleen development;GO:0048538|thymus development;GO:0051603|proteolysis involved in cellular protein catabolic process;GO:0071257|cellular response to electrical stimulus;GO:0071347|cellular response to interleukin-1;GO:0098586|cellular response to virus;GO:1901423|response to benzene;GO:2000116|regulation of cysteine-type endopeptidase activity;","GO:0000502|proteasome complex;GO:0005634|nucleus;GO:0005829|cytosol;GO:0005839|proteasome core complex;GO:0019774|proteasome core complex, beta-subunit complex;GO:1990111|spermatoproteasome complex;","GO:0004298|threonine-type endopeptidase activity;GO:0070628|proteasome binding;","K02741","PSMB9, LMP2; 20S proteasome subunit beta 9 [EC:3.4.25.1]"]
["ENSRNOG00000028566",957,79.45651412,355,22.83730556,3.479242064,1.798773056,{"v":2.4399e-101,"d":"2.44E-101"},{"v":4.1825e-100,"d":"4.18E-100"},"up","yes","Pld4","protein_coding","chr6:131818860-131826376:+","gi|187281923|ref|NP_001119760.1|",2755,0,"phospholipase D4 [Rattus norvegicus]","gi|187281922|ref|NM_001126288.1|",1989,0,"Rattus norvegicus phospholipase D family, member 4 (Pld4), mRNA","Q8BG07",876,0,"Phospholipase D4",".",".",".",".","pfam13918","PLDc_3","PLD-like domain.","GO:0002244|hematopoietic progenitor cell differentiation;GO:0006259|DNA metabolic process;GO:0006909|phagocytosis;GO:0090305|nucleic acid phosphodiester bond hydrolysis;GO:1900015|regulation of cytokine production involved in inflammatory response;","GO:0005634|nucleus;GO:0005769|early endosome;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0032588|trans-Golgi network membrane;GO:0045335|phagocytic vesicle;","GO:0045145|single-stranded DNA 5'-3' exodeoxyribonuclease activity;","K16860","PLD3_4; phospholipase D3/4 [EC:3.1.4.4]"]
["ENSRNOG00000020699",555,46.07979659,102,6.561704695,7.022534347,2.811991775,{"v":4.2608e-101,"d":"4.26E-101"},{"v":7.2458e-100,"d":"7.25E-100"},"up","yes","Cd37","protein_coding","chr1:95719190-95724648:-","gi|74212826|dbj|BAE33374.1|",923,{"v":3e-117,"d":"3.00E-117"},"unnamed protein product [Mus musculus]","gi|74212825|dbj|AK155663.1|",897,0,"Mus musculus B6-derived CD11 +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F730112L14 product:CD37 antigen, full insert sequence","P31053",348,{"v":1e-113,"d":"1.00E-113"},"Leukocyte antigen CD37",".",".",".",".","pfam00335","Tetraspannin","Tetraspanin family.","GO:0002639|positive regulation of immunoglobulin production;GO:0002920|regulation of humoral immune response;GO:0008285|negative regulation of cell proliferation;GO:0030886|negative regulation of myeloid dendritic cell activation;GO:0042832|defense response to protozoan;GO:0050688|regulation of defense response to virus;","GO:0001772|immunological synapse;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;",".","K06475","CD37, TSPAN26; CD37 antigen"]
["ENSRNOG00000000699",421,34.95422408,39,2.508887089,13.93216308,3.80034736,{"v":1.7803e-99,"d":"1.78E-99"},{"v":3.00357e-98,"d":"3.00E-98"},"up","yes","Selplg","protein_coding","chr12:42796580-42812585:+","gi|61557366|ref|NP_001013248.1|",2026,0,"P-selectin glycoprotein ligand 1 precursor [Rattus norvegicus]","gi|157100914|emb|AM778467.1|",1188,0,"Rattus norvegicus mRNA for P-selectin glycoprotein ligand 1 propeptide precursor (Selplg gene)","Q62170",551,{"v":3e-177,"d":"3.00E-177"},"P-selectin glycoprotein ligand 1",".",".",".",".","pfam05109","Herpes_BLLF1","Herpes virus major outer envelope glycoprotein (BLLF1). This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralizing antibodies in vivo.","GO:0030097|hemopoiesis;GO:0050900|leukocyte migration;GO:0050901|leukocyte tethering or rolling;GO:0050902|leukocyte adhesive activation;GO:0071354|cellular response to interleukin-6;","GO:0001931|uropod;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0044853|plasma membrane raft;",".","K06544","SELPLG, CD162; selectin P ligand"]
["ENSRNOG00000048636",389,32.29737094,25,1.608260955,20.08217065,4.327843311,{"v":2.7379e-99,"d":"2.74E-99"},{"v":4.60687e-98,"d":"4.61E-98"},"up","yes","Il2rb","protein_coding","chr7:110033341-110048054:-","gi|564360935|ref|XP_006242032.1|",2407,0,"PREDICTED: interleukin-2 receptor subunit beta isoform X1 [Rattus norvegicus]","gi|672059844|ref|XM_006241970.2|",2553,0,"PREDICTED: Rattus norvegicus interleukin 2 receptor, beta (Il2rb), transcript variant X1, mRNA","P26896",894,0,"Interleukin-2 receptor subunit beta",".",".",".",".","pfam00041","fn3","Fibronectin type III domain.","GO:0019221|cytokine-mediated signaling pathway;GO:0030101|natural killer cell activation;GO:0035723|interleukin-15-mediated signaling pathway;GO:0038110|interleukin-2-mediated signaling pathway;GO:0043066|negative regulation of apoptotic process;GO:0050766|positive regulation of phagocytosis;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0004896|cytokine receptor activity;GO:0004911|interleukin-2 receptor activity;GO:0019976|interleukin-2 binding;GO:0042010|interleukin-15 receptor activity;","K05069","IL2RB, CD122; interleukin 2 receptor beta"]
["ENSRNOG00000062480",392,32.54645093,29,1.865582707,17.44572931,4.124802005,{"v":1.5101e-97,"d":"1.51E-97"},{"v":2.50148e-96,"d":"2.50E-96"},"up","yes","ENSRNOG00000062480","protein_coding","chr1:69429269-69447438:+","gi|672013100|ref|XP_008772637.1|",1643,0,"PREDICTED: leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X1 [Rattus norvegicus]","gi|672013099|ref|XM_008774415.1|",1779,0,"PREDICTED: Rattus norvegicus leukocyte immunoglobulin-like receptor subfamily B member 4 (LOC103690369), transcript variant X1, mRNA","Q9HCN6",119,{"v":3E-28,"d":"3.00E-28"},"Platelet glycoprotein VI",".",".",".",".","pfam13927","Ig_3","Immunoglobulin domain. This family contains immunoglobulin-like domains.",".",".",".",".","."]
["ENSRNOG00000009331",494,41.0151703,78,5.017774178,8.173976915,3.031038169,{"v":5.48507e-97,"d":"5.49E-97"},{"v":9.03921e-96,"d":"9.04E-96"},"up","yes","Hck","protein_coding","chr3:141571587-141614693:+","gi|34734058|ref|NP_037317.2|",2793,0,"tyrosine-protein kinase HCK [Rattus norvegicus]","gi|319918868|ref|NM_013185.3|",2054,0,"Rattus norvegicus hemopoietic cell kinase (Hck), mRNA","P50545",1080,0,"Tyrosine-protein kinase HCK","YAR019c",109,{"v":7e-24,"d":"7.00E-24"},"COG0515","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0006887|exocytosis;GO:0006909|phagocytosis;GO:0006954|inflammatory response;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0008284|positive regulation of cell proliferation;GO:0008360|regulation of cell shape;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0030154|cell differentiation;GO:0043066|negative regulation of apoptotic process;GO:0045087|innate immune response;GO:0046777|protein autophosphorylation;GO:0050764|regulation of phagocytosis;GO:0050830|defense response to Gram-positive bacterium;GO:0051090|regulation of DNA-binding transcription factor activity;GO:0071801|regulation of podosome assembly;GO:2000251|positive regulation of actin cytoskeleton reorganization;","GO:0005634|nucleus;GO:0005764|lysosome;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0005901|caveola;GO:0005925|focal adhesion;GO:0030133|transport vesicle;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0042995|cell projection;GO:0043231|intracellular membrane-bounded organelle;","GO:0001784|phosphotyrosine residue binding;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0005102|signaling receptor binding;GO:0005524|ATP binding;","K08893","HCK; hemopoietic cell kinase [EC:2.7.10.2]"]
["ENSRNOG00000017749",360,29.88959779,15,0.964956573,30.97507041,4.953035657,{"v":5.93871e-97,"d":"5.94E-97"},{"v":9.76163e-96,"d":"9.76E-96"},"up","yes","Nkg7","protein_coding","chr1:93844902-93845983:+","gi|19424202|ref|NP_598224.1|",739,{"v":5e-95,"d":"5.00E-95"},"protein NKG7 [Rattus norvegicus]","gi|298910231|emb|FQ222255.1|",590,0,"Rattus norvegicus TL0ADA26YC12 mRNA sequence","Q99PA5",230,{"v":2E-73,"d":"2.00E-73"},"Protein NKG7",".",".",".",".","pfam13903","Claudin_2","PMP-22/EMP/MP20/Claudin tight junction. Members of this family are claudins, that form tight junctions between cells.","GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;",".","."]
["ENSRNOG00000019854",456,37.8601572,62,3.988487167,9.492360288,3.24676686,{"v":2.34274e-95,"d":"2.34E-95"},{"v":3.83113e-94,"d":"3.83E-94"},"up","yes","Napsa","protein_coding","chr1:95064900-95077094:+","gi|13928928|ref|NP_113858.1|",2075,0,"napsin-A precursor [Rattus norvegicus]","gi|162135962|ref|NM_031670.2|",1306,0,"Rattus norvegicus napsin A aspartic peptidase (Napsa), mRNA","O09043",722,0,"Napsin-A",".",".",".",".","pfam00026","Asp","Eukaryotic aspartyl protease. Aspartyl (acid) proteases include pepsins, cathepsins, and renins. Two-domain structure, probably arising from ancestral duplication. This family does not include the retroviral nor retrotransposon proteases (pfam00077), which are much smaller and appear to be homologous to a single domain of the eukaryotic asp proteases.","GO:0033619|membrane protein proteolysis;GO:0043129|surfactant homeostasis;","GO:0005615|extracellular space;GO:0005764|lysosome;GO:0097208|alveolar lamellar body;","GO:0004175|endopeptidase activity;GO:0004190|aspartic-type endopeptidase activity;GO:0008233|peptidase activity;","K08565","NAPSA; napsin-A [EC:3.4.23.-]"]
["ENSRNOG00000017980",517,42.92478349,93,5.982730751,7.174781095,2.842934815,{"v":2.41138e-95,"d":"2.41E-95"},{"v":3.93332E-94,"d":"3.93E-94"},"up","yes","Itgal","protein_coding","chr1:181918183-181955732:+","gi|564331001|ref|XP_006230331.1|",5895,0,"PREDICTED: integrin alpha-L isoform X1 [Rattus norvegicus]","gi|672038444|ref|XM_006230269.2|",4356,0,"PREDICTED: Rattus norvegicus integrin, alpha L (Itgal), transcript variant X1, mRNA","P24063",1983,0,"Integrin alpha-L",".",".",".",".","pfam08441","Integrin_alpha2","Integrin alpha. This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.","GO:0002291|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007159|leukocyte cell-cell adhesion;GO:0007160|cell-matrix adhesion;GO:0007166|cell surface receptor signaling pathway;GO:0007229|integrin-mediated signaling pathway;GO:0022407|regulation of cell-cell adhesion;GO:0022409|positive regulation of cell-cell adhesion;GO:0035683|memory T cell extravasation;GO:0042102|positive regulation of T cell proliferation;GO:0043113|receptor clustering;GO:0050798|activated T cell proliferation;GO:0050850|positive regulation of calcium-mediated signaling;GO:0098609|cell-cell adhesion;","GO:0001772|immunological synapse;GO:0005911|cell-cell junction;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0034687|integrin alphaL-beta2 complex;","GO:0030369|ICAM-3 receptor activity;GO:0044877|protein-containing complex binding;GO:0046872|metal ion binding;GO:0050839|cell adhesion molecule binding;","K05718","ITGAL, CD11a; integrin alpha L"]
["ENSRNOG00000001431",592,49.15178303,135,8.684609155,5.659642496,2.500710925,{"v":4.08148e-95,"d":"4.08E-95"},{"v":6.62371e-94,"d":"6.62E-94"},"up","yes","Rasa4","protein_coding","chr12:20552806-20580147:-","gi|293341124|ref|XP_002724855.1|",4054,0,"PREDICTED: ras GTPase-activating protein 4 [Rattus norvegicus]","gi|672026669|ref|XM_002724809.3|",2805,0,"PREDICTED: Rattus norvegicus RAS p21 protein activator 4 (Rasa4), mRNA","Q6PFQ7",1483,0,"Ras GTPase-activating protein 4",".",".",".",".","pfam00616","RasGAP","GTPase-activator protein for Ras-like GTPase. All alpha-helical domain that accelerates the GTPase activity of Ras, thereby \"switching\" it into an \"off\" position.","GO:0035556|intracellular signal transduction;GO:0043087|regulation of GTPase activity;GO:0046580|negative regulation of Ras protein signal transduction;GO:0071277|cellular response to calcium ion;",".","GO:0005096|GTPase activator activity;GO:0005543|phospholipid binding;GO:0046872|metal ion binding;","K17630","RASA4, CAPRI; Ras GTPase-activating protein 4"]
["ENSRNOG00000009912",402,33.37671753,38,2.444556651,13.65348499,3.771197334,{"v":1.39626E-94,"d":"1.40E-94"},{"v":2.24317e-93,"d":"2.24E-93"},"up","yes","Fgr","protein_coding","chr5:145189841-145217326:+","gi|564353313|ref|XP_006239140.1|",2763,0,"PREDICTED: tyrosine-protein kinase Fgr isoform X2 [Rattus norvegicus]","gi|40254760|ref|NM_024145.2|",2480,0,"Rattus norvegicus FGR proto-oncogene, Src family tyrosine kinase (Fgr), mRNA","Q6P6U0",1056,0,"Tyrosine-protein kinase Fgr","BH2504_1",98.2,{"v":4e-21,"d":"4.00E-21"},"COG0515","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001819|positive regulation of cytokine production;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007229|integrin-mediated signaling pathway;GO:0008150|biological_process;GO:0008360|regulation of cell shape;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0030154|cell differentiation;GO:0030282|bone mineralization;GO:0030335|positive regulation of cell migration;GO:0032815|negative regulation of natural killer cell activation;GO:0043306|positive regulation of mast cell degranulation;GO:0043552|positive regulation of phosphatidylinositol 3-kinase activity;GO:0045087|innate immune response;GO:0045088|regulation of innate immune response;GO:0045859|regulation of protein kinase activity;GO:0046777|protein autophosphorylation;GO:0048705|skeletal system morphogenesis;GO:0050764|regulation of phagocytosis;GO:0050830|defense response to Gram-positive bacterium;","GO:0005743|mitochondrial inner membrane;GO:0005758|mitochondrial intermembrane space;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0015629|actin cytoskeleton;GO:0016235|aggresome;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0032587|ruffle membrane;","GO:0001784|phosphotyrosine residue binding;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0005102|signaling receptor binding;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0019901|protein kinase binding;GO:0034987|immunoglobulin receptor binding;GO:0034988|Fc-gamma receptor I complex binding;","K08891","FGR, SRC2; tyrosine-protein kinase Fgr [EC:2.7.10.2]"]
["ENSRNOG00000010872",1614,134.0050301,903,58.09038568,2.306836639,1.205915842,{"v":1.78415e-94,"d":"1.78E-94"},{"v":2.85916E-93,"d":"2.86E-93"},"up","yes","Ckb","protein_coding","chr6:130729423-130732315:-","gi|56388799|gb|AAH87656.1|",1983,0,"Ckb protein, partial [Rattus norvegicus]","gi|401461783|ref|NM_012529.3|",1412,0,"Rattus norvegicus creatine kinase, brain (Ckb), mRNA","P07335",747,0,"Creatine kinase B-type","CAC3190",74.7,{"v":7e-14,"d":"7.00E-14"},"COG3869","pfam00217","ATP-gua_Ptrans","ATP:guanido phosphotransferase, C-terminal catalytic domain. The substrate binding site is located in the cleft between N and C-terminal domains, but most of the catalytic residues are found in the larger C-terminal domain.","GO:0007420|brain development;GO:0016310|phosphorylation;GO:0021549|cerebellum development;GO:0021762|substantia nigra development;GO:0030644|cellular chloride ion homeostasis;GO:0046314|phosphocreatine biosynthetic process;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005739|mitochondrion;GO:0005829|cytosol;GO:0030425|dendrite;GO:0043025|neuronal cell body;","GO:0004111|creatine kinase activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0016301|kinase activity;GO:0031625|ubiquitin protein ligase binding;","K00933","E2.7.3.2; creatine kinase [EC:2.7.3.2]"]
["ENSRNOG00000056947",377,31.30105102,29,1.865582707,16.77816314,4.068512874,{"v":3.70072E-93,"d":"3.70E-93"},{"v":5.84266e-92,"d":"5.84E-92"},"up","yes","AABR07025272.1","protein_coding","chr16:27840998-27951324:-","gi|564324417|ref|XP_006227112.1|",8478,0,"PREDICTED: probable ATP-dependent RNA helicase DDX60 isoform X3 [Rattus norvegicus]","gi|672033286|ref|XM_006227050.2|",5363,0,"PREDICTED: Rattus norvegicus DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 (Ddx60), transcript variant X3, mRNA","Q8IY21",2542,0,"Probable ATP-dependent RNA helicase DDX60","SPAC694.02",460,{"v":4e-132,"d":"4.00E-132"},"COG4581","pfam00270","DEAD","DEAD/DEAH box helicase. Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolizm, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.",".",".",".",".","."]
["ENSRNOG00000065741",363,30.13867777,25,1.608260955,18.7399176,4.228042704,{"v":1.0845E-91,"d":"1.08E-91"},{"v":1.69545e-90,"d":"1.70E-90"},"up","yes","Il7r","protein_coding","chr2:58454217-58477757:-","gi|157823237|ref|NP_001099888.1|",2463,0,"interleukin-7 receptor subunit alpha precursor [Rattus norvegicus]","gi|157823236|ref|NM_001106418.1|",3124,0,"Rattus norvegicus interleukin 7 receptor (Il7r), mRNA","P16872",743,0,"Interleukin-7 receptor subunit alpha",".",".",".",".","pfam00041","fn3","Fibronectin type III domain.",".",".",".",".","."]
["ENSRNOG00000029195",748,62.10394207,241,15.5036356,4.005766368,2.00207828,{"v":1.23327e-91,"d":"1.23E-91"},{"v":1.92333e-90,"d":"1.92E-90"},"up","yes","Uba7","protein_coding","chr8:108665292-108674099:+","gi|564365408|ref|XP_006243803.1|",5231,0,"PREDICTED: ubiquitin-like modifier-activating enzyme 7 isoform X1 [Rattus norvegicus]","gi|672062911|ref|XM_006243741.2|",3163,0,"PREDICTED: Rattus norvegicus ubiquitin-like modifier activating enzyme 7 (Uba7), transcript variant X1, mRNA","P41226",1400,0,"Ubiquitin-like modifier-activating enzyme 7","YKL210w",700,0,"COG0476","pfam00899","ThiF","ThiF family. This family contains a repeated domain in ubiquitin activating enzyme E1 and members of the bacterial ThiF/MoeB/HesA family.","GO:0006464|cellular protein modification process;GO:0006974|cellular response to DNA damage stimulus;GO:0016567|protein ubiquitination;GO:0019941|modification-dependent protein catabolic process;GO:0032020|ISG15-protein conjugation;GO:0032446|protein modification by small protein conjugation;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0004839|ubiquitin activating enzyme activity;GO:0004842|ubiquitin-protein transferase activity;GO:0005524|ATP binding;GO:0019782|ISG15 activating enzyme activity;","K10698","UBE1L, UBA7; ubiquitin-activating enzyme E1-like [EC:6.2.1.45]"]
["ENSRNOG00000060821",1745,144.8815226,1046,67.28963834,2.153103006,1.106417341,{"v":4.11775e-89,"d":"4.12E-89"},{"v":6.29888e-88,"d":"6.30E-88"},"up","yes","Rnf114","protein_coding","chr3:156222498-156234256:+","gi|672048156|ref|XP_008760737.1|",1250,{"v":1e-163,"d":"1.00E-163"},"PREDICTED: E3 ubiquitin-protein ligase RNF114 isoform X1 [Rattus norvegicus]","gi|672048155|ref|XM_008762515.1|",1913,0,"PREDICTED: Rattus norvegicus ring finger protein 114 (Rnf114), transcript variant X1, mRNA","Q6J2U6",348,{"v":3e-112,"d":"3.00E-112"},"E3 ubiquitin-protein ligase RNF114",".",".",".",".","pfam05605","zf-Di19","Drought induced 19 protein (Di19), zinc-binding. This family consists of several drought induced 19 (Di19) like proteins. Di19 has been found to be strongly expressed in both the roots and leaves of Arabidopsis thaliana during progressive drought. This domain is a zinc-binding domain.","GO:0000209|protein polyubiquitination;GO:0006511|ubiquitin-dependent protein catabolic process;GO:0007283|spermatogenesis;GO:0030154|cell differentiation;","GO:0005634|nucleus;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;","K15697","RNF114; E3 ubiquitin-protein ligase RNF114 [EC:2.3.2.27]"]
["ENSRNOG00000012172",577,47.90638312,140,9.006261346,5.319230842,2.411217648,{"v":4.97815E-89,"d":"4.98E-89"},{"v":7.59685e-88,"d":"7.60E-88"},"up","yes","Spi1","protein_coding","chr3:77073012-77092393:+","gi|564341813|ref|XP_006234594.1|",1276,{"v":4e-169,"d":"4.00E-169"},"PREDICTED: transcription factor PU.1 isoform X1 [Rattus norvegicus]","gi|672046223|ref|XM_006234532.2|",2027,0,"PREDICTED: Rattus norvegicus Spi-1 proto-oncogene (Spi1), transcript variant X1, mRNA","Q6BDS1",489,{"v":5E-168,"d":"5.00E-168"},"Transcription factor PU.1",".",".",".",".","pfam00178","Ets","Ets-domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001944|vasculature development;GO:0002314|germinal center B cell differentiation;GO:0002316|follicular B cell differentiation;GO:0002320|lymphoid progenitor cell differentiation;GO:0002327|immature B cell differentiation;GO:0002357|defense response to tumor cell;GO:0002572|pro-T cell differentiation;GO:0002573|myeloid leukocyte differentiation;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0030098|lymphocyte differentiation;GO:0030154|cell differentiation;GO:0030218|erythrocyte differentiation;GO:0030225|macrophage differentiation;GO:0030851|granulocyte differentiation;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0035019|somatic stem cell population maintenance;GO:0036462|TRAIL-activated apoptotic signaling pathway;GO:0043011|myeloid dendritic cell differentiation;GO:0043314|negative regulation of neutrophil degranulation;GO:0043966|histone H3 acetylation;GO:0044027|hypermethylation of CpG island;GO:0045347|negative regulation of MHC class II biosynthetic process;GO:0045646|regulation of erythrocyte differentiation;GO:0045814|negative regulation of gene expression, epigenetic;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051090|regulation of DNA-binding transcription factor activity;GO:0060033|anatomical structure regression;GO:0070102|interleukin-6-mediated signaling pathway;GO:0071361|cellular response to ethanol;GO:0090241|negative regulation of histone H4 acetylation;GO:0090402|oncogene-induced cell senescence;GO:0098508|endothelial to hematopoietic transition;GO:0120186|negative regulation of protein localization to chromatin;GO:1900745|positive regulation of p38MAPK cascade;GO:1901223|negative regulation of NIK/NF-kappaB signaling;GO:1901674|regulation of histone H3-K27 acetylation;GO:1902262|apoptotic process involved in blood vessel morphogenesis;GO:1902895|positive regulation of pri-miRNA transcription by RNA polymerase II;GO:1904151|positive regulation of microglial cell mediated cytotoxicity;GO:1904178|negative regulation of adipose tissue development;GO:1904238|pericyte cell differentiation;GO:1905036|positive regulation of antifungal innate immune response;GO:1905453|regulation of myeloid progenitor cell differentiation;GO:2000529|positive regulation of myeloid dendritic cell chemotaxis;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987|proximal promoter sequence-specific DNA binding;GO:0001216|bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding;GO:0001217|bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003700|DNA-binding transcription factor activity;GO:0005515|protein binding;GO:0042826|histone deacetylase binding;GO:0043565|sequence-specific DNA binding;GO:0051525|NFAT protein binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;GO:0097677|STAT family protein binding;","K09438","SPI1; transcription factor PU.1"]
["ENSRNOG00000054493",374,31.05197104,35,2.251565336,13.79128135,3.785684599,{"v":2.34836e-88,"d":"2.35E-88"},{"v":3.56667E-87,"d":"3.57E-87"},"up","yes","Rpph1","ribozyme","chr15:24033662-24033959:-","gi|426376198|ref|XP_004054894.1|",150,{"v":1E-10,"d":"1.00E-10"},"PREDICTED: uncharacterized protein LOC101140100 [Gorilla gorilla gorilla]","gi|157742930|gb|BC116202.1|",256,{"v":4e-130,"d":"4.00E-130"},"Mus musculus cDNA clone IMAGE:40090112",".",".",".",".",".",".",".",".","pfam03362","Herpes_UL47","Herpesvirus UL47 protein.","GO:0008150|biological_process;","GO:0005575|cellular_component;","GO:0003674|molecular_function;",".","."]
["ENSRNOG00000052444",1278,106.1080722,654,42.07210657,2.522052752,1.334598452,{"v":9.151e-88,"d":"9.15E-88"},{"v":1.38001E-86,"d":"1.38E-86"},"up","yes","Samd9","protein_coding","chr4:31164510-31184322:-","gi|109471717|ref|XP_575365.2|",8244,0,"PREDICTED: sterile alpha motif domain-containing protein 9 [Rattus norvegicus]","gi|672018002|ref|XM_006224823.2|",5080,0,"PREDICTED: Rattus norvegicus similar to OEF2 (RGD1563091), transcript variant X2, mRNA","Q5K651",2419,0,"Sterile alpha motif domain-containing protein 9",".",".",".",".","pfam10310","DUF2413","Protein of unknown function (DUF2413). This is a family of proteins conserved in fungi. The function is not known.","GO:0002244|hematopoietic progenitor cell differentiation;GO:0017145|stem cell division;GO:0034058|endosomal vesicle fusion;GO:0035726|common myeloid progenitor cell proliferation;GO:0042176|regulation of protein catabolic process;GO:0048536|spleen development;","GO:0005737|cytoplasm;GO:0005769|early endosome;GO:0005829|cytosol;GO:0043231|intracellular membrane-bounded organelle;",".","K23949","SAMD9, SAMD9L; sterile alpha motif domain-contaning protein 9"]
["ENSRNOG00000048053",404,33.54277085,51,3.280852347,10.22379775,3.353859297,{"v":4.92821e-87,"d":"4.93E-87"},{"v":7.39706e-86,"d":"7.40E-86"},"up","yes","AC128859.3","protein_coding","chr10:67953273-67983840:+","gi|293340296|ref|XP_002724574.1|",1817,0,"PREDICTED: schlafen family member 12 [Rattus norvegicus]","gi|49457868|gb|AC128859.4|",2216,0,"Rattus norvegicus 10 BAC CH230-436I22 (Children's Hospital Oakland Research Institute) complete sequence","Q8IYM2",321,{"v":8e-96,"d":"8.00E-96"},"Schlafen family member 12",".",".",".",".","pfam04326","AAA_4","Divergent AAA domain. This family is related to the pfam00004 family, and presumably has the same function (ATP-binding).",".",".",".",".","."]
["ENSRNOG00000023993",817,67.83278165,305,19.62078365,3.457190236,1.789599992,{"v":3.37108e-86,"d":"3.37E-86"},{"v":5.0128e-85,"d":"5.01E-85"},"up","yes","Kif1a","protein_coding","chr9:93563045-93647480:-","gi|568908181|ref|XP_006529221.1|",8907,0,"PREDICTED: kinesin-like protein KIF1A isoform X5 [Mus musculus]","gi|755493818|ref|XM_006529158.2|",5209,0,"PREDICTED: Mus musculus kinesin family member 1A (Kif1a), transcript variant X4, mRNA","O60333",2387,0,"Kinesin-like protein KIF1B","SPAC1834.07",222,{"v":7e-60,"d":"7.00E-60"},"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0007018|microtubule-based movement;GO:0008089|anterograde axonal transport;GO:0016192|vesicle-mediated transport;GO:0022027|interkinetic nuclear migration;GO:0030705|cytoskeleton-dependent intracellular transport;GO:0060998|regulation of dendritic spine development;GO:0061001|regulation of dendritic spine morphogenesis;GO:0098840|protein transport along microtubule;GO:0099519|dense core granule cytoskeletal transport;GO:1990048|anterograde neuronal dense core vesicle transport;GO:1990049|retrograde neuronal dense core vesicle transport;","GO:0005829|cytosol;GO:0005871|kinesin complex;GO:0005874|microtubule;GO:0008021|synaptic vesicle;GO:0030424|axon;GO:0030425|dendrite;GO:0032991|protein-containing complex;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0048471|perinuclear region of cytoplasm;GO:0098674|extrinsic component of neuronal dense core vesicle membrane;GO:0098793|presynapse;GO:0098794|postsynapse;GO:0098992|neuronal dense core vesicle;GO:1904115|axon cytoplasm;","GO:0003777|microtubule motor activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0008017|microtubule binding;GO:0008574|ATP-dependent microtubule motor activity, plus-end-directed;GO:0016887|ATPase activity;GO:0042802|identical protein binding;","K10392","KIF1; kinesin family member 1"]
["ENSRNOG00000019440",371,30.80289105,37,2.380226213,12.94116118,3.693895167,{"v":3.41363e-86,"d":"3.41E-86"},{"v":5.06429e-85,"d":"5.06E-85"},"up","yes","Kcnn4","protein_coding","chr1:79959322-79974340:+","gi|397739060|ref|NP_075410.2|",1884,0,"intermediate conductance calcium-activated potassium channel protein 4 isoform a [Rattus norvegicus]","gi|397739059|ref|NM_023021.2|",1924,0,"Rattus norvegicus potassium calcium-activated channel subfamily N member 4 (Kcnn4), transcript variant 1, mRNA","O89109",709,0,"Intermediate conductance calcium-activated potassium channel protein 4",".",".",".",".","pfam03530","SK_channel","Calcium-activated SK potassium channel.","GO:0002376|immune system process;GO:0006811|ion transport;GO:0006813|potassium ion transport;GO:0006816|calcium ion transport;GO:0006820|anion transport;GO:0006884|cell volume homeostasis;GO:0030322|stabilization of membrane potential;GO:0045332|phospholipid translocation;GO:0046541|saliva secretion;GO:0050714|positive regulation of protein secretion;GO:0050862|positive regulation of T cell receptor signaling pathway;GO:0071805|potassium ion transmembrane transport;GO:0097623|potassium ion export across plasma membrane;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0031982|vesicle;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0045121|membrane raft;","GO:0005267|potassium channel activity;GO:0005516|calmodulin binding;GO:0015269|calcium-activated potassium channel activity;GO:0016286|small conductance calcium-activated potassium channel activity;GO:0019903|protein phosphatase binding;GO:0022894|Intermediate conductance calcium-activated potassium channel activity;","K04945","KCNN4, KCA3.1; potassium intermediate/small conductance calcium-activated channel subfamily N member 4"]
["ENSRNOG00000059268",1630,135.3334567,967,62.20753372,2.175515545,1.121357326,{"v":3.79954e-85,"d":"3.80E-85"},{"v":5.57216e-84,"d":"5.57E-84"},"up","yes","Ppp1r10","protein_coding","chr20:2822995-2837611:-","gi|672085805|ref|XP_008770985.1|",2407,0,"PREDICTED: serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1 [Rattus norvegicus]","gi|261399865|ref|NM_022951.2|",4170,0,"Rattus norvegicus protein phosphatase 1, regulatory subunit 10 (Ppp1r10), mRNA","O55000",927,0,"Serine/threonine-protein phosphatase 1 regulatory subunit 10",".",".",".",".","pfam08711","Med26","TFIIS helical bundle-like domain. Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species {1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Mediator exists in two major forms in human cells: a smaller form that interacts strongly with pol II and activates transcription, and a large form that does not interact strongly with pol II and does not directly activate transcription. Notably, the 'small' and 'large' Mediator complexes differ in their subunit composition: the Med26 subunit preferentially associates with the small, active complex, whereas cdk8, cyclin C, Med12 and Med13 associate with the large Mediator complex. This family includesthe C terminal region of a number of eukaryotic hypothetical proteins which are homologous to the Saccharomyces cerevisiae protein IWS1. IWS1 is known to be an Pol II transcription elongation factor and interacts with Spt6 and Spt5.","GO:0010667|negative regulation of cardiac muscle cell apoptotic process;GO:0032206|positive regulation of telomere maintenance;GO:0043086|negative regulation of catalytic activity;GO:1904290|negative regulation of mitotic DNA damage checkpoint;","GO:0000781|chromosome, telomeric region;GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0016604|nuclear body;GO:0072357|PTW/PP1 phosphatase complex;","GO:0003677|DNA binding;GO:0003723|RNA binding;GO:0004864|protein phosphatase inhibitor activity;GO:0008157|protein phosphatase 1 binding;GO:0046872|metal ion binding;","K17552","PPP1R10; protein phosphatase 1 regulatory subunit 10"]
["ENSRNOG00000020953",372,30.88591772,40,2.573217527,12.00283979,3.585303872,{"v":1.40781E-84,"d":"1.41E-84"},{"v":2.04119e-83,"d":"2.04E-83"},"up","yes","Ms4a7","protein_coding","chr1:207968761-207983260:-","gi|157823009|ref|NP_001099808.1|",1150,{"v":6E-153,"d":"6.00E-153"},"membrane-spanning 4-domains subfamily A member 7 [Rattus norvegicus]","gi|448824828|ref|NM_001276398.1|",939,0,"Mus musculus membrane-spanning 4-domains, subfamily A, member 7 (Ms4a7), transcript variant 3, mRNA","Q9GZW8",196,{"v":7e-57,"d":"7.00E-57"},"Membrane-spanning 4-domains subfamily A member 7",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.",".","GO:0005802|trans-Golgi network;GO:0016021|integral component of membrane;",".","K22191","MS4A5_6_7; membrane-spanning 4-domains subfamily A member 5/6/7"]
["ENSRNOG00000001889",1448,120.2226044,814,52.36497668,2.295859027,1.199034059,{"v":3.32249e-84,"d":"3.32E-84"},{"v":4.79556e-83,"d":"4.80E-83"},"up","yes","Comt","protein_coding","chr11:82568025-82587642:+","gi|564377561|ref|XP_006248665.1|",1233,{"v":1e-154,"d":"1.00E-154"},"PREDICTED: catechol O-methyltransferase isoform X1 [Rattus norvegicus]","gi|55889|emb|Z12651.1|",4161,0,"R.norvegicus gene for catechol methyltransferase","P22734",479,{"v":6e-156,"d":"6.00E-156"},"Catechol O-methyltransferase","SPBC119.03",139,{"v":7e-35,"d":"7.00E-35"},"COG4122","pfam01596","Methyltransf_3","O-methyltransferase. Members of this family are O-methyltransferases. The family includes catechol o-methyltransferase, caffeoyl-CoA O-methyltransferase, and a family of bacterial O-methyltransferases that may be involved in antibiotic production.","GO:0007565|female pregnancy;GO:0007612|learning;GO:0007614|short-term memory;GO:0008210|estrogen metabolic process;GO:0009410|response to xenobiotic stimulus;GO:0009712|catechol-containing compound metabolic process;GO:0014070|response to organic cyclic compound;GO:0016036|cellular response to phosphate starvation;GO:0032259|methylation;GO:0032496|response to lipopolysaccharide;GO:0032502|developmental process;GO:0035814|negative regulation of renal sodium excretion;GO:0042135|neurotransmitter catabolic process;GO:0042417|dopamine metabolic process;GO:0042420|dopamine catabolic process;GO:0042424|catecholamine catabolic process;GO:0043627|response to estrogen;GO:0045963|negative regulation of dopamine metabolic process;GO:0046498|S-adenosylhomocysteine metabolic process;GO:0046500|S-adenosylmethionine metabolic process;GO:0048265|response to pain;GO:0048609|multicellular organismal reproductive process;GO:0048662|negative regulation of smooth muscle cell proliferation;GO:0050668|positive regulation of homocysteine metabolic process;GO:0051930|regulation of sensory perception of pain;GO:1903489|positive regulation of lactation;","GO:0005615|extracellular space;GO:0005829|cytosol;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0043197|dendritic spine;GO:0043231|intracellular membrane-bounded organelle;GO:0044297|cell body;GO:0045211|postsynaptic membrane;GO:0097386|glial cell projection;","GO:0000287|magnesium ion binding;GO:0008171|O-methyltransferase activity;GO:0016206|catechol O-methyltransferase activity;GO:0102084|L-dopa O-methyltransferase activity;GO:0102938|orcinol O-methyltransferase activity;","K00545","COMT; catechol O-methyltransferase [EC:2.1.1.6]"]
["ENSRNOG00000059097",375,31.1349977,42,2.701878404,11.5234637,3.526502519,{"v":3.41259e-84,"d":"3.41E-84"},{"v":4.91452e-83,"d":"4.91E-83"},"up","yes","AABR07025140.1","protein_coding","chr16:28076999-28179526:-","gi|564324417|ref|XP_006227112.1|",8538,0,"PREDICTED: probable ATP-dependent RNA helicase DDX60 isoform X3 [Rattus norvegicus]","gi|672033286|ref|XM_006227050.2|",5280,0,"PREDICTED: Rattus norvegicus DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 (Ddx60), transcript variant X3, mRNA","Q8IY21",2548,0,"Probable ATP-dependent RNA helicase DDX60","SPAC694.02",457,{"v":2E-131,"d":"2.00E-131"},"COG4581","pfam00270","DEAD","DEAD/DEAH box helicase. Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolizm, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.",".",".",".",".","."]
["ENSRNOG00000064635",641,53.2200894,192,12.35144413,4.308815134,2.107291202,{"v":4.82141e-84,"d":"4.82E-84"},{"v":6.91223e-83,"d":"6.91E-83"},"up","yes","Ly49si2","protein_coding","chr4:163514541-163751214:-","gi|57222324|ref|NP_001009498.1|",1439,0,"immunoreceptor Ly49si2 [Rattus norvegicus]","gi|672051472|ref|XM_006237116.2|",1128,0,"PREDICTED: Rattus norvegicus immunoreceptor Ly49si3 (Ly49si3), transcript variant X2, mRNA","Q60652",316,{"v":2E-100,"d":"2.00E-100"},"Killer cell lectin-like receptor 5",".",".",".",".","pfam08391","Ly49","Ly49-like protein, N-terminal region. The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).",".",".",".",".","."]
["ENSRNOG00000000815",1419,117.8148313,795,51.14269836,2.303649105,1.20392098,{"v":4.45469e-83,"d":"4.45E-83"},{"v":6.35798e-82,"d":"6.36E-82"},"up","yes","Smpdl3a","protein_coding","chr20:37132592-37155567:+","gi|53850608|ref|NP_001005539.1|",2397,0,"acid sphingomyelinase-like phosphodiesterase 3a precursor [Rattus norvegicus]","gi|53850607|ref|NM_001005539.1|",1661,0,"Rattus norvegicus sphingomyelin phosphodiesterase, acid-like 3A (Smpdl3a), mRNA","Q641Z7",927,0,"Acid sphingomyelinase-like phosphodiesterase 3a",".",".",".",".","pfam00149","Metallophos","Calcineurin-like phosphoesterase. This family includes a diverse range of phosphoesterases, including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD or yeast MRE11. The most conserved regions in this superfamily centre around the metal chelating residues.","GO:0009143|nucleoside triphosphate catabolic process;","GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0008081|phosphoric diester hydrolase activity;GO:0008270|zinc ion binding;","K01128","SMPDL3; sphingomyelin phosphodiesterase acid-like 3 [EC:3.1.4.-]"]
["ENSRNOG00000021199",593,49.23480969,166,10.67885274,4.610496174,2.204922019,{"v":2.50058E-82,"d":"2.50E-82"},{"v":3.5531e-81,"d":"3.55E-81"},"up","yes","Fcgr1a","protein_coding","chr2:183851077-183859994:-","gi|158631264|ref|NP_001094306.1|",1822,0,"high affinity immunoglobulin gamma Fc receptor I precursor [Rattus norvegicus]","gi|165971690|gb|BC158809.1|",1249,0,"Rattus norvegicus Fc fragment of IgG, high affinity Ia, receptor (CD64), mRNA (cDNA clone MGC:188236 IMAGE:7364883), complete cds","P26151",615,0,"High affinity immunoglobulin gamma Fc receptor I",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0001788|antibody-dependent cellular cytotoxicity;GO:0001798|positive regulation of type IIa hypersensitivity;GO:0001805|positive regulation of type III hypersensitivity;GO:0006898|receptor-mediated endocytosis;GO:0006910|phagocytosis, recognition;GO:0006911|phagocytosis, engulfment;GO:0007166|cell surface receptor signaling pathway;GO:0009617|response to bacterium;GO:0019884|antigen processing and presentation of exogenous antigen;GO:0032355|response to estradiol;GO:0038094|Fc-gamma receptor signaling pathway;GO:0042590|antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:0042742|defense response to bacterium;GO:0050766|positive regulation of phagocytosis;GO:0050776|regulation of immune response;GO:0060100|positive regulation of phagocytosis, engulfment;GO:0061098|positive regulation of protein tyrosine kinase activity;GO:0071871|response to epinephrine;GO:1904058|positive regulation of sensory perception of pain;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0045121|membrane raft;","GO:0004888|transmembrane signaling receptor activity;GO:0005515|protein binding;GO:0019770|IgG receptor activity;GO:0019864|IgG binding;GO:0031774|leukotriene receptor binding;","K06498","FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I"]
["ENSRNOG00000030689",374,31.05197104,45,2.894869718,10.72655216,3.42311452,{"v":4.71308e-82,"d":"4.71E-82"},{"v":6.66724e-81,"d":"6.67E-81"},"up","yes","Ms4a6bl","protein_coding","chr1:208153530-208174479:+","gi|564298878|ref|XP_002725833.2|",1081,{"v":2e-141,"d":"2.00E-141"},"PREDICTED: membrane-spanning 4-domains subfamily A member 6C-like isoform X3 [Rattus norvegicus]","gi|672014682|ref|XM_006223653.2|",794,0,"PREDICTED: Rattus norvegicus membrane-spanning 4-domains, subfamily A, member 6C (Ms4a6c), transcript variant X4, mRNA","Q99N08",305,{"v":4e-98,"d":"4.00E-98"},"Membrane-spanning 4-domains subfamily A member 6C",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.",".","GO:0016021|integral component of membrane;",".","K22191","MS4A5_6_7; membrane-spanning 4-domains subfamily A member 5/6/7"]
["ENSRNOG00000018414",979,81.28310065,441,28.36972324,2.865135482,1.51860336,{"v":8.42481E-82,"d":"8.42E-82"},{"v":1.17876E-80,"d":"1.18E-80"},"up","yes","Csf1r","protein_coding","chr18:54546659-54590415:+","gi|564393690|ref|XP_006254875.1|",5059,0,"PREDICTED: macrophage colony-stimulating factor 1 receptor isoform X1 [Rattus norvegicus]","gi|672083476|ref|XM_008772148.1|",3845,0,"PREDICTED: Rattus norvegicus colony stimulating factor 1 receptor (Csf1r), transcript variant X3, mRNA","P09581",1738,0,"Macrophage colony-stimulating factor 1 receptor",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001934|positive regulation of protein phosphorylation;GO:0002244|hematopoietic progenitor cell differentiation;GO:0002931|response to ischemia;GO:0006954|inflammatory response;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007275|multicellular organism development;GO:0007411|axon guidance;GO:0007519|skeletal muscle tissue development;GO:0008283|cell proliferation;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0008360|regulation of cell shape;GO:0010759|positive regulation of macrophage chemotaxis;GO:0014005|microglia development;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0019221|cytokine-mediated signaling pathway;GO:0021542|dentate gyrus development;GO:0021772|olfactory bulb development;GO:0021879|forebrain neuron differentiation;GO:0030097|hemopoiesis;GO:0030316|osteoclast differentiation;GO:0030335|positive regulation of cell migration;GO:0031529|ruffle organization;GO:0032722|positive regulation of chemokine production;GO:0032944|regulation of mononuclear cell proliferation;GO:0033674|positive regulation of kinase activity;GO:0036006|cellular response to macrophage colony-stimulating factor stimulus;GO:0038145|macrophage colony-stimulating factor signaling pathway;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0043066|negative regulation of apoptotic process;GO:0044794|positive regulation by host of viral process;GO:0045087|innate immune response;GO:0045124|regulation of bone resorption;GO:0045217|cell-cell junction maintenance;GO:0045672|positive regulation of osteoclast differentiation;GO:0046488|phosphatidylinositol metabolic process;GO:0046777|protein autophosphorylation;GO:0048015|phosphatidylinositol-mediated signaling;GO:0061098|positive regulation of protein tyrosine kinase activity;GO:0061518|microglial cell proliferation;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071345|cellular response to cytokine stimulus;GO:0071902|positive regulation of protein serine/threonine kinase activity;GO:0120041|positive regulation of macrophage proliferation;GO:1990138|neuron projection extension;GO:2000147|positive regulation of cell motility;GO:2000249|regulation of actin cytoskeleton reorganization;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0043235|receptor complex;GO:1990682|CSF1-CSF1R complex;","GO:0003674|molecular_function;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0005011|macrophage colony-stimulating factor receptor activity;GO:0005524|ATP binding;GO:0019903|protein phosphatase binding;GO:0019955|cytokine binding;GO:0042803|protein homodimerization activity;","K05090","CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]"]
["ENSRNOG00000020150",958,79.53954078,425,27.34043623,2.909227202,1.540635971,{"v":9.25806e-82,"d":"9.26E-82"},{"v":1.29251e-80,"d":"1.29E-80"},"up","yes","Il18bp","protein_coding","chr1:156372883-156374963:-","gi|149068682|gb|EDM18234.1|",991,{"v":1e-131,"d":"1.00E-131"},"interleukin 18 binding protein, isoform CRA_b [Rattus norvegicus]","gi|672038104|ref|XM_008759805.1|",776,0,"PREDICTED: Rattus norvegicus interleukin 18 binding protein (Il18bp), transcript variant X1, mRNA","Q9Z0M9",277,{"v":2E-90,"d":"2.00E-90"},"Interleukin-18-binding protein",".",".",".",".","pfam05566","Pox_vIL-18BP","Orthopoxvirus interleukin 18 binding protein. Interleukin-18 (IL-18) is a proinflammatory cytokine that plays a key role in the activation of natural killer and T helper 1 cell responses principally by inducing interferon-gamma (IFN-gamma). Several poxvirus genes encode proteins with sequence similarity to IL-18BPs. It has been shown that vaccinia, ectromelia and cowpox viruses secrete from infected cells a soluble IL-18BP (vIL-18BP) that may modulate the host antiviral response. The expression of vIL-18BPs by distinct poxvirus genera that cause local or general viral dissemination, or persistent or acute infections in the host, emphasises the importance of IL-18 in response to viral infections.","GO:0032496|response to lipopolysaccharide;GO:0042088|T-helper 1 type immune response;GO:0070301|cellular response to hydrogen peroxide;GO:0071356|cellular response to tumor necrosis factor;","GO:0005615|extracellular space;","GO:0005515|protein binding;GO:0042007|interleukin-18 binding;","K25565","IL18BP; interleukin-18-binding protein"]
["ENSRNOG00000008194",749,62.18696873,273,17.56220962,3.540953562,1.824137924,{"v":3.07702e-81,"d":"3.08E-81"},{"v":4.26785E-80,"d":"4.27E-80"},"up","yes","Znfx1","protein_coding","chr3:155764980-155821242:-","gi|114145712|ref|NP_001041325.1|",10388,0,"NFX1-type zinc finger-containing protein 1 [Rattus norvegicus]","gi|114145711|ref|NM_001047860.1|",6059,0,"Rattus norvegicus zinc finger, NFX1-type containing 1 (Znfx1), mRNA","Q8R151",3518,0,"NFX1-type zinc finger-containing protein 1","SPCC1739.03",207,{"v":3e-53,"d":"3.00E-53"},"COG1112","pfam13087","AAA_12","AAA domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.","GO:0031048|chromatin silencing by small RNA;","GO:0031380|nuclear RNA-directed RNA polymerase complex;","GO:0003723|RNA binding;GO:0004386|helicase activity;GO:0008270|zinc ion binding;",".","."]
["ENSRNOG00000018092",616,51.14442288,185,11.90113106,4.297442202,2.103478236,{"v":1.17122E-80,"d":"1.17E-80"},{"v":1.62098e-79,"d":"1.62E-79"},"up","yes","Cd83","protein_coding","chr17:20887309-20907083:-","gi|157822369|ref|NP_001101880.1|",919,{"v":2E-116,"d":"2.00E-116"},"CD83 antigen precursor [Rattus norvegicus]","gi|157822368|ref|NM_001108410.1|",2119,0,"Rattus norvegicus CD83 molecule (Cd83), mRNA","O88324",340,{"v":1e-110,"d":"1.00E-110"},"CD83 antigen",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0014070|response to organic cyclic compound;GO:0032713|negative regulation of interleukin-4 production;GO:0032733|positive regulation of interleukin-10 production;GO:0032743|positive regulation of interleukin-2 production;GO:0043372|positive regulation of CD4-positive, alpha-beta T cell differentiation;","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;",".","K06510","CD83; CD83 antigen"]
["ENSRNOG00000021100",675,56.04299585,225,14.47434859,3.871883802,1.953035657,{"v":2.79434e-80,"d":"2.79E-80"},{"v":3.85071e-79,"d":"3.85E-79"},"up","yes","Tnfaip8l2","protein_coding","chr2:182709378-182726760:-","gi|62078809|ref|NP_001014061.1|",870,{"v":1e-105,"d":"1.00E-105"},"tumor necrosis factor alpha-induced protein 8-like protein 2 [Rattus norvegicus]","gi|672043420|ref|XM_008761303.1|",2137,0,"PREDICTED: Rattus norvegicus tumor necrosis factor, alpha-induced protein 8-like 2 (Tnfaip8l2), transcript variant X1, mRNA","Q6AYJ8",339,{"v":4E-107,"d":"4.00E-107"},"Tumor necrosis factor alpha-induced protein 8-like protein 2",".",".",".",".","pfam05527","DUF758","Domain of unknown function (DUF758). Family of eukaryotic proteins with unknown function, which are induced by tumor necrosis factor.","GO:0042981|regulation of apoptotic process;GO:0045087|innate immune response;GO:0050728|negative regulation of inflammatory response;GO:0050868|negative regulation of T cell activation;","GO:0005737|cytoplasm;",".",".","."]
["ENSRNOG00000000795",978,81.20007399,448,28.82003631,2.817486874,1.494408889,{"v":7.57968e-80,"d":"7.58E-80"},{"v":1.04003E-78,"d":"1.04E-78"},"up","yes","RT1-N3","protein_coding","chr20:2661584-2665530:+","gi|57012390|ref|NP_001008855.1|",1798,0,"RT1 class Ib, locus N3 [Rattus norvegicus]","gi|261878534|ref|NM_001008855.2|",1450,0,"Rattus norvegicus RT1 class Ib, locus N3 (RT1-N3), mRNA","P01897",331,{"v":7E-105,"d":"7.00E-105"},"H-2 class I histocompatibility antigen, L-D alpha chain",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.","GO:0001916|positive regulation of T cell mediated cytotoxicity;GO:0002476|antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002486|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0006955|immune response;","GO:0005615|extracellular space;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0005102|signaling receptor binding;GO:0042605|peptide antigen binding;","K06751","MHC1; MHC class I antigen"]
["ENSRNOG00000070397",1149,95.39763294,585,37.63330634,2.534925634,1.341943424,{"v":9.45799e-80,"d":"9.46E-80"},{"v":1.29498E-78,"d":"1.29E-78"},"up","yes","C4b","protein_coding","chr20:4197366-4211681:+","gi|50657362|ref|NP_001002805.1|",9057,0,"complement component 4, gene 2 precursor [Rattus norvegicus]","gi|259013548|ref|NM_001002805.2|",5351,0,"Rattus norvegicus complement component 4B (Chido blood group) (C4b), mRNA","P08649",3423,0,"Complement C4","TM0984",61.2,3e-08,"COG2373","pfam07678","A2M_comp","A-macroglobulin complement component. This family includes the complement components region of the alpha-2-macroglobulin family.",".",".",".",".","."]
["ENSRNOG00000006418",430,35.70146403,78,5.017774178,7.115000149,2.830863787,{"v":2.76583e-79,"d":"2.77E-79"},{"v":3.75478e-78,"d":"3.75E-78"},"up","yes","Samhd1","protein_coding","chr3:145761558-145794386:-","gi|403225011|ref|NP_001178672.1|",2980,0,"deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [Rattus norvegicus]","gi|403225010|ref|NM_001191743.1|",2036,0,"Rattus norvegicus SAM domain and HD domain, 1 (Samhd1), mRNA","Q60710",1044,0,"Deoxynucleoside triphosphate triphosphohydrolase SAMHD1","TM1547",132,{"v":1e-31,"d":"1.00E-31"},"COG1078","pfam01966","HD","HD domain. HD domains are metal dependent phosphohydrolases.","GO:0000724|double-strand break repair via homologous recombination;GO:0006203|dGTP catabolic process;GO:0006974|cellular response to DNA damage stimulus;GO:0009264|deoxyribonucleotide catabolic process;GO:0016446|somatic hypermutation of immunoglobulin genes;GO:0045088|regulation of innate immune response;GO:0046061|dATP catabolic process;GO:0051289|protein homotetramerization;GO:0051607|defense response to virus;GO:0060339|negative regulation of type I interferon-mediated signaling pathway;GO:0090501|RNA phosphodiester bond hydrolysis;GO:0110025|DNA strand resection involved in replication fork processing;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0035861|site of double-strand break;GO:0097197|tetraspanin-enriched microdomain;","GO:0003676|nucleic acid binding;GO:0003697|single-stranded DNA binding;GO:0003723|RNA binding;GO:0004540|ribonuclease activity;GO:0005525|GTP binding;GO:0008270|zinc ion binding;GO:0008832|dGTPase activity;GO:0016793|triphosphoric monoester hydrolase activity;GO:0032567|dGTP binding;GO:0042802|identical protein binding;","K22544","SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]"]
["ENSRNOG00000028768",311,25.82129142,21,1.350939202,19.11358512,4.256526504,{"v":4.2052e-79,"d":"4.21E-79"},{"v":5.69672e-78,"d":"5.70E-78"},"up","yes","Gbp4","protein_coding","chr2:231305244-231318879:+","gi|149026108|gb|EDL82351.1|",3190,0,"rCG28728, isoform CRA_a [Rattus norvegicus]","gi|765365471|ref|NM_001305261.1|",2560,0,"Rattus norvegicus guanylate binding protein 4 (Gbp4), mRNA","Q61107",1088,0,"Guanylate-binding protein 4",".",".",".",".","pfam02263","GBP","Guanylate-binding protein, N-terminal domain. Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.","GO:0035458|cellular response to interferon-beta;GO:0042832|defense response to protozoan;GO:0044406|adhesion of symbiont to host;GO:0050830|defense response to Gram-positive bacterium;GO:0071346|cellular response to interferon-gamma;","GO:0005634|nucleus;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0031410|cytoplasmic vesicle;GO:0048471|perinuclear region of cytoplasm;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;","K20899","GBP1_3_4_7; guanylate-binding protein 1/3/4/7"]
["ENSRNOG00000005620",494,41.0151703,115,7.398000391,5.54408869,2.470950337,{"v":1.24288e-78,"d":"1.24E-78"},{"v":1.67308E-77,"d":"1.67E-77"},"up","yes","Lcp2","protein_coding","chr10:18642658-18689559:+","gi|18426850|ref|NP_569105.1|",2156,0,"lymphocyte cytosolic protein 2 [Rattus norvegicus]","gi|71896578|ref|NM_130421.2|",3361,0,"Rattus norvegicus lymphocyte cytosolic protein 2 (Lcp2), mRNA","Q60787",751,0,"Lymphocyte cytosolic protein 2",".",".",".",".","pfam00017","SH2","SH2 domain.","GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0035556|intracellular signal transduction;GO:0045576|mast cell activation;GO:0045860|positive regulation of protein kinase activity;GO:0050852|T cell receptor signaling pathway;","GO:0005829|cytosol;GO:0005911|cell-cell junction;GO:0036398|TCR signalosome;GO:0044853|plasma membrane raft;",".","K07361","LCP2; lymphocyte cytosolic protein 2"]
["ENSRNOG00000012160",536,44.50229004,142,9.134922222,4.871666004,2.284415227,{"v":8.20365e-78,"d":"8.20E-78"},{"v":1.09509e-76,"d":"1.10E-76"},"up","yes","Syk","protein_coding","chr17:12604619-12661410:-","gi|149044986|gb|EDL98072.1|",3332,0,"spleen tyrosine kinase, isoform CRA_a [Rattus norvegicus]","gi|6981619|ref|NM_012758.1|",5188,0,"Rattus norvegicus spleen tyrosine kinase (Syk), mRNA","Q64725",1261,0,"Tyrosine-protein kinase SYK","Rv0015c",91.7,{"v":3e-18,"d":"3.00E-18"},"COG0515","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001525|angiogenesis;GO:0001775|cell activation;GO:0001819|positive regulation of cytokine production;GO:0001820|serotonin secretion;GO:0001945|lymph vessel development;GO:0002092|positive regulation of receptor internalization;GO:0002223|stimulatory C-type lectin receptor signaling pathway;GO:0002250|adaptive immune response;GO:0002281|macrophage activation involved in immune response;GO:0002283|neutrophil activation involved in immune response;GO:0002366|leukocyte activation involved in immune response;GO:0002554|serotonin secretion by platelet;GO:0006468|protein phosphorylation;GO:0006606|protein import into nucleus;GO:0007159|leukocyte cell-cell adhesion;GO:0007166|cell surface receptor signaling pathway;GO:0007167|enzyme linked receptor protein signaling pathway;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007229|integrin-mediated signaling pathway;GO:0010543|regulation of platelet activation;GO:0010803|regulation of tumor necrosis factor-mediated signaling pathway;GO:0018105|peptidyl-serine phosphorylation;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0019370|leukotriene biosynthetic process;GO:0030154|cell differentiation;GO:0030593|neutrophil chemotaxis;GO:0031334|positive regulation of protein complex assembly;GO:0031623|receptor internalization;GO:0032481|positive regulation of type I interferon production;GO:0032725|positive regulation of granulocyte macrophage colony-stimulating factor production;GO:0032733|positive regulation of interleukin-10 production;GO:0032735|positive regulation of interleukin-12 production;GO:0032752|positive regulation of interleukin-3 production;GO:0032753|positive regulation of interleukin-4 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032928|regulation of superoxide anion generation;GO:0032930|positive regulation of superoxide anion generation;GO:0033630|positive regulation of cell adhesion mediated by integrin;GO:0035556|intracellular signal transduction;GO:0038063|collagen-activated tyrosine kinase receptor signaling pathway;GO:0038156|interleukin-3-mediated signaling pathway;GO:0042742|defense response to bacterium;GO:0043280|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043306|positive regulation of mast cell degranulation;GO:0043313|regulation of neutrophil degranulation;GO:0043366|beta selection;GO:0043410|positive regulation of MAPK cascade;GO:0043507|positive regulation of JUN kinase activity;GO:0045087|innate immune response;GO:0045579|positive regulation of B cell differentiation;GO:0045588|positive regulation of gamma-delta T cell differentiation;GO:0045780|positive regulation of bone resorption;GO:0046638|positive regulation of alpha-beta T cell differentiation;GO:0046641|positive regulation of alpha-beta T cell proliferation;GO:0046777|protein autophosphorylation;GO:0048514|blood vessel morphogenesis;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050764|regulation of phagocytosis;GO:0050776|regulation of immune response;GO:0050850|positive regulation of calcium-mediated signaling;GO:0050853|B cell receptor signaling pathway;GO:0051090|regulation of DNA-binding transcription factor activity;GO:0051712|positive regulation of killing of cells of other organism;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:0071226|cellular response to molecule of fungal origin;GO:0071396|cellular response to lipid;GO:0071404|cellular response to low-density lipoprotein particle stimulus;GO:0071639|positive regulation of monocyte chemotactic protein-1 production;GO:0090237|regulation of arachidonic acid secretion;GO:0090330|regulation of platelet aggregation;GO:0120162|positive regulation of cold-induced thermogenesis;GO:1900086|positive regulation of peptidyl-tyrosine autophosphorylation;GO:1990858|cellular response to lectin;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0019815|B cell receptor complex;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0032009|early phagosome;GO:0032991|protein-containing complex;GO:0042101|T cell receptor complex;","GO:0001784|phosphotyrosine residue binding;GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0005102|signaling receptor binding;GO:0005178|integrin binding;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0016170|interleukin-15 receptor binding;GO:0019901|protein kinase binding;GO:0019902|phosphatase binding;GO:0019904|protein domain specific binding;GO:0031625|ubiquitin protein ligase binding;GO:0035325|Toll-like receptor binding;GO:0042169|SH2 domain binding;GO:0043274|phospholipase binding;GO:0097110|scaffold protein binding;","K05855","SYK; spleen tyrosine kinase [EC:2.7.10.2]"]
["ENSRNOG00000033256",417,34.62211744,74,4.760452426,7.272862817,2.862523364,{"v":8.53331e-78,"d":"8.53E-78"},{"v":1.13673E-76,"d":"1.14E-76"},"up","yes","ENSRNOG00000033256","protein_coding","chr8:20078639-20095696:+","gi|564362687|ref|XP_006242736.1|",1017,{"v":2e-133,"d":"2.00E-133"},"PREDICTED: protein HIDE1 isoform X3 [Rattus norvegicus]","gi|157819996|ref|NM_001109624.1|",1301,0,"Rattus norvegicus hypothetical protein LOC691141 (LOC691141), mRNA","Q75VT8",300,{"v":3E-98,"d":"3.00E-98"},"Protein HIDE1",".",".",".",".","pfam15242","FAM53","Family of FAM53. The FAM53 protein family refers to a family of proteins, which bind to a transcriptional regulator that modulates cell proliferation. It is known to be highly important in neural tube development. It is found in eukaryotes and is typically between 303 and 413 amino acids in length.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000004249",361,29.97262445,46,2.959200157,10.12862357,3.340366227,{"v":1.02794e-77,"d":"1.03E-77"},{"v":1.36364e-76,"d":"1.36E-76"},"up","yes","ENSRNOG00000004249","protein_coding","chrX:27027425-27054754:+","gi|564398991|ref|XP_006256904.1|",4998,0,"PREDICTED: toll-like receptor 7 isoform X2 [Rattus norvegicus]","gi|672087353|ref|XM_008773170.1|",4113,0,"PREDICTED: Rattus norvegicus toll-like receptor 7 (Tlr7), transcript variant X2, mRNA","P58681",1778,0,"Toll-like receptor 7","MA2301_1",53.9,2e-06,"COG4886","pfam01582","TIR","TIR domain. The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.","GO:0000165|MAPK cascade;GO:0001932|regulation of protein phosphorylation;GO:0002224|toll-like receptor signaling pathway;GO:0002755|MyD88-dependent toll-like receptor signaling pathway;GO:0006954|inflammatory response;GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0007252|I-kappaB phosphorylation;GO:0007254|JNK cascade;GO:0032722|positive regulation of chemokine production;GO:0032727|positive regulation of interferon-alpha production;GO:0032728|positive regulation of interferon-beta production;GO:0032729|positive regulation of interferon-gamma production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0034154|toll-like receptor 7 signaling pathway;GO:0045087|innate immune response;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051607|defense response to virus;GO:0071260|cellular response to mechanical stimulus;GO:0098586|cellular response to virus;GO:1901224|positive regulation of NIK/NF-kappaB signaling;","GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0005768|endosome;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0032009|early phagosome;GO:0043235|receptor complex;","GO:0003725|double-stranded RNA binding;GO:0003727|single-stranded RNA binding;GO:0003953|NAD+ nucleosidase activity;GO:0004888|transmembrane signaling receptor activity;GO:0035197|siRNA binding;GO:0038187|pattern recognition receptor activity;","K05404","TLR7; toll-like receptor 7"]
["ENSRNOG00000042905",449,37.27897058,92,5.918400313,6.29882546,2.655082835,{"v":1.91109e-77,"d":"1.91E-77"},{"v":2.52474e-76,"d":"2.52E-76"},"up","yes","RT1-T24-4","protein_coding","chr20:2684515-2692511:+","gi|77404170|ref|NP_001008826.2|",1830,0,"RT1 class I, locus T24, gene 4 [Rattus norvegicus]","gi|261862313|ref|NM_001008826.3|",1650,0,"Rattus norvegicus RT1 class I, locus T24, gene 4 (RT1-T24-4), mRNA","P16391",383,{"v":5e-127,"d":"5.00E-127"},"RT1 class I histocompatibility antigen, AA alpha chain",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.","GO:0001916|positive regulation of T cell mediated cytotoxicity;GO:0002476|antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002486|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0006955|immune response;","GO:0005615|extracellular space;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0005102|signaling receptor binding;GO:0042605|peptide antigen binding;","K06751","MHC1; MHC class I antigen"]
["ENSRNOG00000069960",303,25.15707814,20,1.286608764,19.5530132,4.289319045,{"v":2.04102e-77,"d":"2.04E-77"},{"v":2.69082E-76,"d":"2.69E-76"},"up","yes","5_8S_rRNA","rRNA","chr3:2234750-2234902:+","gi|954258002|gb|KRX51787.1|",138,1E-8,"hypothetical protein T09_8305 [Trichinella sp. T9]","gi|958786664|ref|XM_014867045.1|",153,{"v":3e-73,"d":"3.00E-73"},"PREDICTED: Equus asinus translation initiation factor IF-2-like (LOC106847650), mRNA",".",".",".",".",".",".",".",".","pfam05346","DUF747","Eukaryotic membrane protein family. This family is a family of eukaryotic membrane proteins. It was previously annotated as including a putative receptor for human cytomegalovirus gH but this has has since been disputed. Analysis of the mouse Tapt1 protein (transmembrane anterior posterior transformation 1) has shown it to be involved in patterning of the vertebrate axial skeleton.",".",".",".",".","."]
["ENSRNOG00000020557",538,44.66834336,146,9.392243975,4.755875537,2.24971096,{"v":1.08232E-76,"d":"1.08E-76"},{"v":1.42104e-75,"d":"1.42E-75"},"up","yes","Ryr1","protein_coding","chr1:84292578-84423812:-","gi|568945162|ref|XP_006539751.1|",23426,0,"PREDICTED: ryanodine receptor 1 isoform X7 [Mus musculus]","gi|755519244|ref|XM_006539688.2|",13203,0,"PREDICTED: Mus musculus ryanodine receptor 1, skeletal muscle (Ryr1), transcript variant X7, mRNA","E9PZQ0",8961,0,"Ryanodine receptor 1",".",".",".",".","pfam01365","RYDR_ITPR","RIH domain. The RIH (RyR and IP3R Homology) domain is an extracellular domain from two types of calcium channels. This region is found in the ryanodine receptor and the inositol-1,4,5- trisphosphate receptor. This domain may form a binding site for IP3.","GO:0001666|response to hypoxia;GO:0003151|outflow tract morphogenesis;GO:0006816|calcium ion transport;GO:0006936|muscle contraction;GO:0014808|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0031000|response to caffeine;GO:0032355|response to estradiol;GO:0043588|skin development;GO:0043931|ossification involved in bone maturation;GO:0048741|skeletal muscle fiber development;GO:0051209|release of sequestered calcium ion into cytosol;GO:0051289|protein homotetramerization;GO:0051480|regulation of cytosolic calcium ion concentration;GO:0070296|sarcoplasmic reticulum calcium ion transport;GO:0071277|cellular response to calcium ion;GO:0071313|cellular response to caffeine;GO:0071318|cellular response to ATP;","GO:0005737|cytoplasm;GO:0005790|smooth endoplasmic reticulum;GO:0005886|plasma membrane;GO:0005938|cell cortex;GO:0014802|terminal cisterna;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016529|sarcoplasmic reticulum;GO:0030018|Z disc;GO:0030314|junctional membrane complex;GO:0030315|T-tubule;GO:0030659|cytoplasmic vesicle membrane;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0031301|integral component of organelle membrane;GO:0031674|I band;GO:0032991|protein-containing complex;GO:0033017|sarcoplasmic reticulum membrane;GO:0034704|calcium channel complex;GO:0042383|sarcolemma;GO:1990425|ryanodine receptor complex;","GO:0002020|protease binding;GO:0005219|ryanodine-sensitive calcium-release channel activity;GO:0005245|voltage-gated calcium channel activity;GO:0005262|calcium channel activity;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0005516|calmodulin binding;GO:0005524|ATP binding;GO:0019899|enzyme binding;GO:0048763|calcium-induced calcium release activity;","K04961","RYR1; ryanodine receptor 1"]
["ENSRNOG00000046216",435,36.11659733,86,5.532417684,6.528176178,2.706679992,{"v":1.29683E-76,"d":"1.30E-76"},{"v":1.69919E-75,"d":"1.70E-75"},"up","yes","RGD1559482","protein_coding","chr10:100156238-100182647:+","gi|564375252|ref|XP_006247801.1|",1012,{"v":4e-132,"d":"4.00E-132"},"PREDICTED: CMRF35-like molecule isoform X1 [Rattus norvegicus]","gi|672070034|ref|XM_006247739.2|",639,0,"PREDICTED: Rattus norvegicus immunoglobulin superfamily, member 7 (Igsf7), transcript variant X2, mRNA","Q7TSN2",261,{"v":7e-82,"d":"7.00E-82"},"CMRF35-like molecule",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0001819|positive regulation of cytokine production;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;",".","K06719","CD300; CD300 antigen"]
["ENSRNOG00000000562",281,23.33049161,11,0.70763482,32.96967722,5.043067858,{"v":1.87609e-76,"d":"1.88E-76"},{"v":2.44317e-75,"d":"2.44E-75"},"up","yes","Prf1","protein_coding","chr20:29246202-29251701:+","gi|149038739|gb|EDL93028.1|",3110,0,"perforin 1 (pore forming protein), isoform CRA_a [Rattus norvegicus]","gi|59709458|ref|NM_017330.2|",1919,0,"Rattus norvegicus perforin 1 (Prf1), mRNA","P35763",1125,0,"Perforin-1",".",".",".",".","pfam01823","MACPF","MAC/Perforin domain. The membrane-attack complex (MAC) of the complement system forms transmembrane channels. These channels disrupt the phospholipid bilayer of target cells, leading to cell lysis and death. A number of proteins participate in the assembly of the MAC. Freshly activated C5b binds to C6 to form a C5b-6 complex, then to C7 forming the C5b-7 complex. The C5b-7 complex binds to C8, which is composed of three chains (alpha, beta, and gamma), thus forming the C5b-8 complex. C5b-8 subsequently binds to C9 and acts as a catalyst in the polymerization of C9. Active MAC has a subunit composition of C5b-C6-C7-C8-C9{n}. Perforin is a protein found in cytolytic T-cell and killer cells. In the presence of calcium, perforin polymerizes into transmembrane tubules and is capable of lysing, non-specifically, a variety of target cells. There are a number of regions of similarity in the sequences of complement components C6, C7, C8-alpha, C8-beta, C9 and perforin. The X-ray crystal structure of a MACPF domain reveals that it shares a common fold with bacterial cholesterol dependent cytolysins (pfam01289) such as perfringolysin O. Three key pieces of evidence suggests that MACPF domains and CDCs are homologous: Functional similarity (pore formation), conservation of three glycine residues at a hinge in both families and conservation of a complex core fold.","GO:0001771|immunological synapse formation;GO:0001913|T cell mediated cytotoxicity;GO:0002357|defense response to tumor cell;GO:0002418|immune response to tumor cell;GO:0006915|apoptotic process;GO:0007623|circadian rhythm;GO:0019835|cytolysis;GO:0045471|response to ethanol;GO:0051260|protein homooligomerization;GO:0051607|defense response to virus;GO:0051712|positive regulation of killing of cells of other organism;GO:0055085|transmembrane transport;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0031410|cytoplasmic vesicle;GO:0031904|endosome lumen;GO:0044194|cytolytic granule;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;GO:0022829|wide pore channel activity;GO:0042802|identical protein binding;","K07818","PRF1; perforin 1"]
["ENSRNOG00000028548",284,23.57957159,3,0.192991315,122.1794444,6.932857775,{"v":7.14611e-76,"d":"7.15E-76"},{"v":9.19376e-75,"d":"9.19E-75"},"up","yes","Ccl9","protein_coding","chr10:68366487-68371369:-","gi|59891435|ref|NP_001012357.1|",623,{"v":1e-76,"d":"1.00E-76"},"C-C motif chemokine 9 precursor [Rattus norvegicus]","gi|59891434|ref|NM_001012357.1|",1288,0,"Rattus norvegicus chemokine (C-C motif) ligand 9 (Ccl9), mRNA","P51670",182,{"v":4e-54,"d":"4.00E-54"},"C-C motif chemokine 9",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0002548|monocyte chemotaxis;GO:0006954|inflammatory response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0030593|neutrophil chemotaxis;GO:0043547|positive regulation of GTPase activity;GO:0048247|lymphocyte chemotaxis;GO:0070098|chemokine-mediated signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;","GO:0005615|extracellular space;","GO:0008009|chemokine activity;GO:0048020|CCR chemokine receptor binding;","K22671","CCL9; C-C motif chemokine 9"]
["ENSRNOG00000019353",1258,104.4475389,695,44.70965454,2.336129411,1.224120195,{"v":8.81316e-76,"d":"8.81E-76"},{"v":1.13157E-74,"d":"1.13E-74"},"up","yes","Psmb10","protein_coding","chr19:33827229-33833626:-","gi|149038059|gb|EDL92419.1|",1207,{"v":8e-160,"d":"8.00E-160"},"chymotrypsin-like, isoform CRA_a [Rattus norvegicus]","gi|298892872|emb|FQ211893.1|",1134,0,"Rattus norvegicus TL0AAA77YD16 mRNA sequence","P40313",415,{"v":4e-140,"d":"4.00E-140"},"Chymotrypsin-like protease CTRL-1","VC1649",96.7,{"v":3e-20,"d":"3.00E-20"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;","GO:0005615|extracellular space;","GO:0004252|serine-type endopeptidase activity;GO:0008233|peptidase activity;GO:0008236|serine-type peptidase activity;","K09632","CTRL; chymotrypsin-like protease [EC:3.4.21.-]"]
["ENSRNOG00000010529",356,29.55749115,47,3.023530595,9.775820095,3.289217735,{"v":1.09195E-75,"d":"1.09E-75"},{"v":1.3992e-74,"d":"1.40E-74"},"up","yes","Thbs2","protein_coding","chr1:55670394-55699789:-","gi|281332082|ref|NP_001162609.1|",5716,0,"thrombospondin-2 precursor [Rattus norvegicus]","gi|281332081|ref|NM_001169138.1|",5728,0,"Rattus norvegicus thrombospondin 2 (Thbs2), mRNA","Q03350",2156,0,"Thrombospondin-2",".",".",".",".","pfam05735","TSP_C","Thrombospondin C-terminal region. This region is found at the C-terminus of thrombospondin and related proteins.","GO:0007155|cell adhesion;GO:0016525|negative regulation of angiogenesis;GO:0051965|positive regulation of synapse assembly;","GO:0005576|extracellular region;GO:0005604|basement membrane;GO:0031012|extracellular matrix;GO:0031091|platelet alpha granule;GO:0062023|collagen-containing extracellular matrix;","GO:0005509|calcium ion binding;GO:0008201|heparin binding;","K04659","THBS2S; thrombospondin 2/3/4/5"]
["ENSRNOG00000014312",270,22.41719834,12,0.771965258,29.03912851,4.859926253,{"v":8.75135e-73,"d":"8.75E-73"},{"v":1.08444e-71,"d":"1.08E-71"},"up","yes","AC109737.1","TR_C_gene","chr4:70417612-70418013:+","gi|68533982|gb|AAH99166.1|",697,{"v":8E-90,"d":"8.00E-90"},"Tcrb protein [Rattus norvegicus]","gi|207192|gb|M63795.1|RATTCBC3",390,0,"Rattus norvegicus T-cell receptor beta-chain (Tcrb) gene, exons 1 through 4 and partial cds","P01852",235,{"v":5e-78,"d":"5.00E-78"},"T-cell receptor beta-1 chain C region",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.",".",".",".",".","."]
["ENSRNOG00000024277",313,25.98734474,33,2.12290446,12.2414104,3.613697884,{"v":7.08419e-72,"d":"7.08E-72"},{"v":8.69425e-71,"d":"8.69E-71"},"up","yes","Card11","protein_coding","chr12:13621087-13758112:+","gi|47847424|dbj|BAD21384.1|",5639,0,"mFLJ00120 protein [Mus musculus]","gi|672026525|ref|XM_008758980.1|",3888,0,"PREDICTED: Rattus norvegicus caspase recruitment domain family, member 11 (LOC100363332), transcript variant X1, mRNA","Q8CIS0",2140,0,"Caspase recruitment domain-containing protein 11",".",".",".",".","pfam00619","CARD","Caspase recruitment domain. Motif contained in proteins involved in apoptotic signaling. Predicted to possess a DEATH (pfam00531) domain-like fold.","GO:0007165|signal transduction;GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0008150|biological_process;GO:0030183|B cell differentiation;GO:0030890|positive regulation of B cell proliferation;GO:0031295|T cell costimulation;GO:0032743|positive regulation of interleukin-2 production;GO:0038202|TORC1 signaling;GO:0042100|B cell proliferation;GO:0042102|positive regulation of T cell proliferation;GO:0042110|T cell activation;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045061|thymic T cell selection;GO:0045577|regulation of B cell differentiation;GO:0045580|regulation of T cell differentiation;GO:0046649|lymphocyte activation;GO:0048872|homeostasis of number of cells;GO:0050776|regulation of immune response;GO:0050862|positive regulation of T cell receptor signaling pathway;GO:0050870|positive regulation of T cell activation;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051260|protein homooligomerization;","GO:0001772|immunological synapse;GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0032449|CBM complex;GO:0045121|membrane raft;","GO:0003674|molecular_function;GO:0043621|protein self-association;GO:0050700|CARD domain binding;","K07367","CARD11; caspase recruitment domain-containing protein 11"]
["ENSRNOG00000005214",381,31.63315766,67,4.310139358,7.33924243,2.875631153,{"v":1.4666E-71,"d":"1.47E-71"},{"v":1.7862e-70,"d":"1.79E-70"},"up","yes","Plek","protein_coding","chr14:91397019-91454131:-","gi|71043674|ref|NP_001020921.1|",1517,0,"pleckstrin [Rattus norvegicus]","gi|71043673|ref|NM_001025750.1|",1056,0,"Rattus norvegicus pleckstrin (Plek), mRNA","Q4KM33",588,0,"Pleckstrin",".",".",".",".","pfam00169","PH","PH domain. PH stands for pleckstrin homology.","GO:0002244|hematopoietic progenitor cell differentiation;GO:0002576|platelet degranulation;GO:0006904|vesicle docking involved in exocytosis;GO:0007229|integrin-mediated signaling pathway;GO:0010572|positive regulation of platelet activation;GO:0010920|negative regulation of inositol phosphate biosynthetic process;GO:0010925|positive regulation of inositol-polyphosphate 5-phosphatase activity;GO:0030030|cell projection organization;GO:0030836|positive regulation of actin filament depolymerization;GO:0030845|phospholipase C-inhibiting G protein-coupled receptor signaling pathway;GO:0030866|cortical actin cytoskeleton organization;GO:0031529|ruffle organization;GO:0031532|actin cytoskeleton reorganization;GO:0032233|positive regulation of actin filament bundle assembly;GO:0033625|positive regulation of integrin activation;GO:0035556|intracellular signal transduction;GO:0045744|negative regulation of G protein-coupled receptor signaling pathway;GO:0046488|phosphatidylinositol metabolic process;GO:0060305|regulation of cell diameter;GO:0070493|thrombin-activated receptor signaling pathway;GO:0070527|platelet aggregation;GO:0070528|protein kinase C signaling;GO:0070560|protein secretion by platelet;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0032587|ruffle membrane;","GO:0005080|protein kinase C binding;GO:0042803|protein homodimerization activity;GO:0043325|phosphatidylinositol-3,4-bisphosphate binding;","K19993","PLEK; pleckstrin"]
["ENSRNOG00000016413",491,40.76609032,130,8.362956964,4.874602427,2.285284557,{"v":1.81041e-71,"d":"1.81E-71"},{"v":2.20075e-70,"d":"2.20E-70"},"up","yes","Pstpip1","protein_coding","chr8:56499590-56538580:+","gi|166157470|ref|NP_001100294.2|",2073,0,"proline-serine-threonine phosphatase-interacting protein 1 [Rattus norvegicus]","gi|166157469|ref|NM_001106824.2|",1539,0,"Rattus norvegicus proline-serine-threonine phosphatase-interacting protein 1 (Pstpip1), mRNA","P97814",768,0,"Proline-serine-threonine phosphatase-interacting protein 1",".",".",".",".","pfam00611","FCH","Fes/CIP4, and EFC/F-BAR homology domain. Alignment extended from. Highly alpha-helical. The cytosolic endocytic adaptor proteins in fungi carry this domain at the N-terminus; several of these have been referred to as muniscin proteins. These N-terminal BAR, N-BAR, and EFC/F-BAR domains are found in proteins that regulate membrane trafficking events by inducing membrane tubulation. The domain dimerises into a curved structure that binds to liposomes and either senses or induces the curvature of the membrane bilayer to cause biophysical changes to the shape of the bilayer; it also thereby recruits other trafficking factors, such as the GTPase dynamin. Most EFC/F-BAR domain-family members localize to actin-rich structures.","GO:0008150|biological_process;GO:0030041|actin filament polymerization;","GO:0001725|stress fiber;GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005826|actomyosin contractile ring;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0032154|cleavage furrow;","GO:0003674|molecular_function;GO:0003779|actin binding;GO:0019903|protein phosphatase binding;GO:0042802|identical protein binding;GO:0051015|actin filament binding;","K12804","PSTPIP1; proline-serine-threonine phosphatase interacting protein 1"]
["ENSRNOG00000008215",603,50.0650763,205,13.18773983,3.79633485,1.924607249,{"v":1.4476E-70,"d":"1.45E-70"},{"v":1.74315e-69,"d":"1.74E-69"},"up","yes","Trim47","protein_coding","chr10:101337573-101342044:-","gi|157818923|ref|NP_001103055.1|",2610,0,"tripartite motif-containing protein 47 [Rattus norvegicus]","gi|157818922|ref|NM_001109585.1|",2198,0,"Rattus norvegicus tripartite motif-containing 47 (Trim47), mRNA","Q8C0E3",979,0,"Tripartite motif-containing protein 47",".",".",".",".","pfam15227","zf-C3HC4_4","zinc finger of C3HC4-type, RING. This is a family of primate-specific Ret finger protein-like (RFPL) zinc-fingers of the C3HC4 type. Ret finger protein-like proteins are primate-specific target genes of Pax6, a key transcription factor for pancreas, eye and neocortex development. This domain is likely to be DNA-binding. This zinc-finger domain together with the RDM domain, pfam11002, forms a large zinc-finger structure of the RING/U-Box superfamily. RING-containing proteins are known to exert an E3 ubiquitin protein ligase activity with the zinc-finger structure being mandatory for binding to the E2 ubiquitin-conjugating enzyme.","GO:0016567|protein ubiquitination;","GO:0005829|cytosol;","GO:0004842|ubiquitin-protein transferase activity;GO:0008270|zinc ion binding;","K12023","TRIM47; tripartite motif-containing protein 47"]
["ENSRNOG00000009705",500,41.51333026,139,8.941930908,4.642546525,2.214916368,{"v":4.32581e-70,"d":"4.33E-70"},{"v":5.18944e-69,"d":"5.19E-69"},"up","yes","Lck","protein_coding","chr5:141888326-141903794:-","gi|564352993|ref|XP_006238994.1|",2810,0,"PREDICTED: proto-oncogene tyrosine-protein kinase LCK isoform X2 [Rattus norvegicus]","gi|672054094|ref|XM_006238932.2|",2118,0,"PREDICTED: Rattus norvegicus LCK proto-oncogene, Src family tyrosine kinase (Lck), transcript variant X1, mRNA","Q01621",1065,0,"Proto-oncogene tyrosine-protein kinase LCK",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0006468|protein phosphorylation;GO:0006470|protein dephosphorylation;GO:0006882|cellular zinc ion homeostasis;GO:0006915|apoptotic process;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007166|cell surface receptor signaling pathway;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007568|aging;GO:0009410|response to xenobiotic stimulus;GO:0009612|response to mechanical stimulus;GO:0010038|response to metal ion;GO:0010043|response to zinc ion;GO:0010628|positive regulation of gene expression;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0030154|cell differentiation;GO:0030217|T cell differentiation;GO:0034116|positive regulation of heterotypic cell-cell adhesion;GO:0035556|intracellular signal transduction;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0042542|response to hydrogen peroxide;GO:0045087|innate immune response;GO:0045588|positive regulation of gamma-delta T cell differentiation;GO:0045589|regulation of regulatory T cell differentiation;GO:0046777|protein autophosphorylation;GO:0050853|B cell receptor signaling pathway;GO:0050856|regulation of T cell receptor signaling pathway;GO:0050870|positive regulation of T cell activation;GO:0051209|release of sequestered calcium ion into cytosol;GO:0070474|positive regulation of uterine smooth muscle contraction;GO:1903039|positive regulation of leukocyte cell-cell adhesion;GO:2001244|positive regulation of intrinsic apoptotic signaling pathway;","GO:0000242|pericentriolar material;GO:0001772|immunological synapse;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0030139|endocytic vesicle;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0045121|membrane raft;GO:0098978|glutamatergic synapse;GO:0099091|postsynaptic specialization, intracellular component;","GO:0001784|phosphotyrosine residue binding;GO:0003823|antigen binding;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0004722|protein serine/threonine phosphatase activity;GO:0005102|signaling receptor binding;GO:0005524|ATP binding;GO:0008022|protein C-terminus binding;GO:0016004|phospholipase activator activity;GO:0019901|protein kinase binding;GO:0019903|protein phosphatase binding;GO:0042169|SH2 domain binding;GO:0042608|T cell receptor binding;GO:0042609|CD4 receptor binding;GO:0042610|CD8 receptor binding;GO:0042802|identical protein binding;GO:0043274|phospholipase binding;GO:0043548|phosphatidylinositol 3-kinase binding;GO:0044877|protein-containing complex binding;GO:0051117|ATPase binding;GO:1990405|protein antigen binding;","K05856","LCK; lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2]"]
["ENSRNOG00000065206",303,25.15707814,1,0.064330438,391.060264,8.61124714,{"v":5.9058e-70,"d":"5.91E-70"},{"v":7.0716e-69,"d":"7.07E-69"},"up","yes","ENSRNOG00000065206","protein_coding","chr1:122867221-122869344:+","gi|672059154|ref|XP_008763709.1|",2906,0,"PREDICTED: MLV-related proviral Env polyprotein-like [Rattus norvegicus]","gi|672059153|ref|XM_008765487.1|",1623,0,"PREDICTED: Rattus norvegicus MLV-related proviral Env polyprotein-like (LOC102551832), mRNA","P21415",489,{"v":6e-163,"d":"6.00E-163"},"Envelope glycoprotein",".",".",".",".","pfam00429","TLV_coat","ENV polyprotein (coat polyprotein).",".",".",".",".","."]
["ENSRNOG00000038129",355,29.47446449,0,0.032165219,916.3458331,9.839748371,{"v":6.54892e-70,"d":"6.55E-70"},{"v":7.81241E-69,"d":"7.81E-69"},"up","yes","Defb52","protein_coding","chr16:70588116-70590626:+","gi|564389783|ref|XP_006253430.1|",551,{"v":5e-70,"d":"5.00E-70"},"PREDICTED: beta-defensin 52 isoform X1 [Rattus norvegicus]","gi|672080546|ref|XM_006253368.2|",415,0,"PREDICTED: Rattus norvegicus defensin beta 52 (Defb52), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam01537","Herpes_glycop_D","Herpesvirus glycoprotein D/GG/GX domain. This domain is found in several Herpes viruses glycoproteins. This is a family includes glycoprotein-D (gD or gIV) which is common to herpes simplex virus types 1 and 2, as well as equine herpes, bovine herpes and Marek's disease virus. Glycoprotein-D has been found on the viral envelope and the plasma membrane of infected cells. and gD immunisation can produce an immune response to bovine herpes virus (BHV-1). This response is stronger than that of the other major glycoproteins gB (gI) and gC (gIII) in BHV-1. Glycoprotein G (gG)is one of the seven external glycoproteins of HSV1 and HSV2. This family also contains the glycoprotein GX, (gX), initially identified in Pseudorabies virus.",".",".",".",".","."]
["ENSRNOG00000008409",613,50.8953429,214,13.76671377,3.696985624,1.886349433,{"v":7.49644e-70,"d":"7.50E-70"},{"v":8.92608e-69,"d":"8.93E-69"},"up","yes","Myo1f","protein_coding","chr7:14363350-14413911:+","gi|157821107|ref|NP_001101546.1|",5505,0,"myosin-If [Rattus norvegicus]","gi|157821106|ref|NM_001108076.1|",3361,0,"Rattus norvegicus myosin IF (Myo1f), mRNA","O00160",2027,0,"Unconventional myosin-If","YMR109w",761,0,"COG5022","pfam00063","Myosin_head","Myosin head (motor domain).","GO:0002446|neutrophil mediated immunity;GO:0007015|actin filament organization;GO:0007162|negative regulation of cell adhesion;GO:0009617|response to bacterium;GO:0030050|vesicle transport along actin filament;GO:0030335|positive regulation of cell migration;GO:0032956|regulation of actin cytoskeleton organization;GO:0043312|neutrophil degranulation;GO:0045088|regulation of innate immune response;GO:0050830|defense response to Gram-positive bacterium;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005902|microvillus;GO:0015629|actin cytoskeleton;GO:0016459|myosin complex;GO:0030864|cortical actin cytoskeleton;GO:0031941|filamentous actin;GO:0031982|vesicle;","GO:0000146|microfilament motor activity;GO:0005516|calmodulin binding;GO:0005524|ATP binding;GO:0051015|actin filament binding;","K10356","MYO1; myosin I"]
["ENSRNOG00000007178",320,26.56853137,41,2.637547966,10.07319363,3.332449246,{"v":5.76394e-69,"d":"5.76E-69"},{"v":6.79986e-68,"d":"6.80E-68"},"up","yes","Cd8a","protein_coding","chr4:103365804-103370040:+","gi|13928726|ref|NP_113726.1|",1047,{"v":4e-138,"d":"4.00E-138"},"T-cell surface glycoprotein CD8 alpha chain precursor [Rattus norvegicus]","gi|672049903|ref|XM_006236630.2|",1388,0,"PREDICTED: Rattus norvegicus CD8a molecule (Cd8a), transcript variant X2, mRNA","P07725",407,{"v":1E-139,"d":"1.00E-139"},"T-cell surface glycoprotein CD8 alpha chain",".",".",".",".","pfam00047","ig","Immunoglobulin domain. Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions. The Pfam alignments do not include the first and last strand of the immunoglobulin-like domain.","GO:0002456|T cell mediated immunity;GO:0006954|inflammatory response;GO:0007166|cell surface receptor signaling pathway;GO:0042110|T cell activation;GO:0045065|cytotoxic T cell differentiation;GO:0050850|positive regulation of calcium-mediated signaling;GO:0051607|defense response to virus;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0044853|plasma membrane raft;","GO:0019901|protein kinase binding;GO:0023024|MHC class I protein complex binding;GO:0042802|identical protein binding;","K06458","CD8A; T-cell surface glycoprotein CD8 alpha chain"]
["ENSRNOG00000004444",276,22.9153583,22,1.41526964,16.19151408,4.017165994,{"v":3.36807e-68,"d":"3.37E-68"},{"v":3.93707e-67,"d":"3.94E-67"},"up","yes","Ikzf1","protein_coding","chr14:86255065-86342416:+","gi|672076803|ref|XP_008768537.1|",2281,0,"PREDICTED: DNA-binding protein Ikaros isoform X6 [Rattus norvegicus]","gi|672076802|ref|XM_008770315.1|",1830,0,"PREDICTED: Rattus norvegicus IKAROS family zinc finger 1 (Ikzf1), transcript variant X11, mRNA","Q03267",736,0,"DNA-binding protein Ikaros",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001779|natural killer cell differentiation;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0010628|positive regulation of gene expression;GO:0030097|hemopoiesis;GO:0030098|lymphocyte differentiation;GO:0030183|B cell differentiation;GO:0030217|T cell differentiation;GO:0030218|erythrocyte differentiation;GO:0030900|forebrain development;GO:0032968|positive regulation of transcription elongation from RNA polymerase II promoter;GO:0035881|amacrine cell differentiation;GO:0040018|positive regulation of multicellular organism growth;GO:0045184|establishment of protein localization;GO:0045660|positive regulation of neutrophil differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045899|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048535|lymph node development;GO:0048538|thymus development;GO:0048541|Peyer's patch development;GO:0048732|gland development;GO:0051138|positive regulation of NK T cell differentiation;GO:0060040|retinal bipolar neuron differentiation;GO:0060041|retina development in camera-type eye;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005721|pericentric heterochromatin;GO:0005829|cytosol;GO:0032991|protein-containing complex;GO:0032993|protein-DNA complex;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0008187|poly-pyrimidine tract binding;GO:0019904|protein domain specific binding;GO:0042802|identical protein binding;GO:0043565|sequence-specific DNA binding;","K09220","IKZF, ZNFN1A; IKAROS family zinc finger protein"]
["ENSRNOG00000011406",247,20.50758515,8,0.514643505,39.84813746,5.316440388,{"v":3.83756e-68,"d":"3.84E-68"},{"v":4.46953e-67,"d":"4.47E-67"},"up","yes","Ccl4","protein_coding","chr10:68452052-68468231:+","gi|564373396|ref|XP_006247028.1|",416,{"v":4e-46,"d":"4.00E-46"},"PREDICTED: C-C motif chemokine 4 isoform X1 [Rattus norvegicus]","gi|672068332|ref|XM_006246966.2|",693,0,"PREDICTED: Rattus norvegicus chemokine (C-C motif) ligand 4 (Ccl4), transcript variant X1, mRNA","P50230",160,{"v":5e-46,"d":"5.00E-46"},"C-C motif chemokine 4",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0002548|monocyte chemotaxis;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007165|signal transduction;GO:0007186|G protein-coupled receptor signaling pathway;GO:0009636|response to toxic substance;GO:0030593|neutrophil chemotaxis;GO:0030595|leukocyte chemotaxis;GO:0032760|positive regulation of tumor necrosis factor production;GO:0043117|positive regulation of vascular permeability;GO:0043547|positive regulation of GTPase activity;GO:0043922|negative regulation by host of viral transcription;GO:0048245|eosinophil chemotaxis;GO:0048247|lymphocyte chemotaxis;GO:0050850|positive regulation of calcium-mediated signaling;GO:0051928|positive regulation of calcium ion transport;GO:0060326|cell chemotaxis;GO:0070098|chemokine-mediated signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071466|cellular response to xenobiotic stimulus;GO:2000503|positive regulation of natural killer cell chemotaxis;","GO:0005615|extracellular space;","GO:0008009|chemokine activity;GO:0031726|CCR1 chemokine receptor binding;GO:0031730|CCR5 chemokine receptor binding;GO:0042802|identical protein binding;GO:0048020|CCR chemokine receptor binding;","K12964","CCL4; C-C motif chemokine 4"]
["ENSRNOG00000048315",1024,85.01930038,537,34.54544531,2.461085669,1.299294878,{"v":6.63511e-68,"d":"6.64E-68"},{"v":7.69974e-67,"d":"7.70E-67"},"up","yes","Eif2ak2","protein_coding","chr6:16188979-16224971:+","gi|672055172|ref|XP_008762647.1|",2664,0,"PREDICTED: interferon-induced, double-stranded RNA-activated protein kinase isoform X2 [Rattus norvegicus]","gi|672055171|ref|XM_008764425.1|",3870,0,"PREDICTED: Rattus norvegicus eukaryotic translation initiation factor 2-alpha kinase 2 (Eif2ak2), transcript variant X1, mRNA","Q63184",981,0,"Interferon-induced, double-stranded RNA-activated protein kinase","L138452_1",107,{"v":2e-23,"d":"2.00E-23"},"COG0515","pfam00069","Pkinase","Protein kinase domain.","GO:0001819|positive regulation of cytokine production;GO:0006412|translation;GO:0006468|protein phosphorylation;GO:0009612|response to mechanical stimulus;GO:0009615|response to virus;GO:0009636|response to toxic substance;GO:0010033|response to organic substance;GO:0010998|regulation of translational initiation by eIF2 alpha phosphorylation;GO:0017148|negative regulation of translation;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0030968|endoplasmic reticulum unfolded protein response;GO:0032496|response to lipopolysaccharide;GO:0032722|positive regulation of chemokine production;GO:0032874|positive regulation of stress-activated MAPK cascade;GO:0033197|response to vitamin E;GO:0033689|negative regulation of osteoblast proliferation;GO:0034198|cellular response to amino acid starvation;GO:0035455|response to interferon-alpha;GO:0043065|positive regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0043330|response to exogenous dsRNA;GO:0043410|positive regulation of MAPK cascade;GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0046777|protein autophosphorylation;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051607|defense response to virus;GO:1900225|regulation of NLRP3 inflammasome complex assembly;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1901532|regulation of hematopoietic progenitor cell differentiation;GO:1902033|regulation of hematopoietic stem cell proliferation;GO:1902036|regulation of hematopoietic stem cell differentiation;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0048471|perinuclear region of cytoplasm;","GO:0003725|double-stranded RNA binding;GO:0004672|protein kinase activity;GO:0004694|eukaryotic translation initiation factor 2alpha kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0042802|identical protein binding;","K16195","EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1]"]
["ENSRNOG00000009227",782,64.92684853,345,22.19400117,2.925423317,1.548645402,{"v":1.40263E-67,"d":"1.40E-67"},{"v":1.6218E-66,"d":"1.62E-66"},"up","yes","Aplnr","protein_coding","chr3:70217385-70221050:+","gi|13786192|ref|NP_112639.1|",1693,0,"apelin receptor [Rattus norvegicus]","gi|48675846|ref|NM_031349.2|",3644,0,"Rattus norvegicus apelin receptor (Aplnr), mRNA","Q9JHG3",656,0,"Apelin receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001525|angiogenesis;GO:0001568|blood vessel development;GO:0001570|vasculogenesis;GO:0001944|vasculature development;GO:0001947|heart looping;GO:0003171|atrioventricular valve development;GO:0003272|endocardial cushion formation;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007369|gastrulation;GO:0007507|heart development;GO:0007512|adult heart development;GO:0010468|regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0031065|positive regulation of histone deacetylation;GO:0035886|vascular smooth muscle cell differentiation;GO:0035904|aorta development;GO:0043951|negative regulation of cAMP-mediated signaling;GO:0045766|positive regulation of angiogenesis;GO:0050878|regulation of body fluid levels;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;GO:0060183|apelin receptor signaling pathway;GO:0060412|ventricular septum morphogenesis;GO:0060841|venous blood vessel development;GO:0060976|coronary vasculature development;GO:1903589|positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:1903596|regulation of gap junction assembly;GO:1904325|positive regulation of inhibitory G protein-coupled receptor phosphorylation;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0042277|peptide binding;GO:0060182|apelin receptor activity;","K04174","APLNR; apelin receptor"]
["ENSRNOG00000070909",255,21.17179843,15,0.964956573,21.94067488,4.455535997,{"v":1.24718e-66,"d":"1.25E-66"},{"v":1.42659E-65,"d":"1.43E-65"},"up","yes","ENSRNOG00000070909","protein_coding","chr4:70403737-70410534:+","gi|149065398|gb|EDM15474.1|",930,{"v":8e-112,"d":"8.00E-112"},"rCG64533, partial [Rattus norvegicus]","gi|207190|gb|M63793.1|RATTCBC1",5175,0,"Rattus norvegicus T-cell receptor beta-chain (Tcrb) gene, exons 1 through 4 and partial cds","P01852",327,{"v":1E-100,"d":"1.00E-100"},"T-cell receptor beta-1 chain C region",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.",".",".",".",".","."]
["ENSRNOG00000023614",263,21.83601172,19,1.222278326,17.86500772,4.159064632,{"v":2.28732e-66,"d":"2.29E-66"},{"v":2.60238e-65,"d":"2.60E-65"},"up","yes","Hsh2d","protein_coding","chr16:17635322-17647991:-","gi|404501493|ref|NP_001258257.1|",1584,0,"hematopoietic SH2 domain-containing protein [Rattus norvegicus]","gi|404501492|ref|NM_001271328.1|",2176,0,"Rattus norvegicus hematopoietic SH2 domain containing (Hsh2d), mRNA","Q6VYH9",509,{"v":3e-174,"d":"3.00E-174"},"Hematopoietic SH2 domain-containing protein",".",".",".",".","pfam00017","SH2","SH2 domain.","GO:0002903|negative regulation of B cell apoptotic process;GO:0007165|signal transduction;GO:0042110|T cell activation;GO:0051902|negative regulation of mitochondrial depolarization;","GO:0005739|mitochondrion;GO:0005829|cytosol;","GO:0030674|protein binding, bridging;","K23699","HSH2D; hematopoietic SH2 domain-containing protein"]
["ENSRNOG00000002659",315,26.15339807,43,2.766208842,9.454599981,3.24101642,{"v":2.36092E-66,"d":"2.36E-66"},{"v":2.68135E-65,"d":"2.68E-65"},"up","yes","Ciita","protein_coding","chr10:5140178-5187440:-","gi|399154121|ref|NP_001257732.1|",5282,0,"MHC class II transactivator isoform 2 [Rattus norvegicus]","gi|399154120|ref|NM_001270803.1|",4849,0,"Rattus norvegicus class II, major histocompatibility complex, transactivator (Ciita), transcript variant 2, mRNA","P79621",1878,0,"MHC class II transactivator",".",".",".",".","pfam05729","NACHT","NACHT domain. This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006954|inflammatory response;GO:0007568|aging;GO:0034341|response to interferon-gamma;GO:0045345|positive regulation of MHC class I biosynthetic process;GO:0045348|positive regulation of MHC class II biosynthetic process;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046597|negative regulation of viral entry into host cell;GO:0046677|response to antibiotic;GO:0071257|cellular response to electrical stimulus;GO:0071346|cellular response to interferon-gamma;GO:0071360|cellular response to exogenous dsRNA;","GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0009986|cell surface;GO:0016605|PML body;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0003674|molecular_function;GO:0005524|ATP binding;GO:0008022|protein C-terminus binding;GO:0044877|protein-containing complex binding;","K08060","CIITA; MHC class II transactivator [EC:2.7.11.1]"]
["ENSRNOG00000031138",483,40.10187703,138,8.87760047,4.517197769,2.175428078,{"v":2.56713e-66,"d":"2.57E-66"},{"v":2.90522e-65,"d":"2.91E-65"},"up","yes","Irgm","protein_coding","chr10:33233455-33241578:-","gi|58865582|ref|NP_001012007.1|",2100,0,"immunity-related GTPase family M protein [Rattus norvegicus]","gi|58865581|ref|NM_001012007.1|",2208,0,"Rattus norvegicus immunity-related GTPase family, M (Irgm), mRNA","Q6AYC2",813,0,"Immunity-related GTPase family M protein",".",".",".",".","pfam05049","IIGP","Interferon-inducible GTPase (IIGP). Interferon-inducible GTPase (IIGP) is thought to play a role in in intracellular defence. IIGP is predominantly associated with the Golgi apparatus and also localizes to the endoplasmic reticulum and exerts a distinct role in IFN-induced intracellular membrane trafficking or processing.","GO:0000045|autophagosome assembly;GO:0001934|positive regulation of protein phosphorylation;GO:0006952|defense response;GO:0009617|response to bacterium;GO:0010508|positive regulation of autophagy;GO:0010800|positive regulation of peptidyl-threonine phosphorylation;GO:0031648|protein destabilization;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0035458|cellular response to interferon-beta;GO:0042742|defense response to bacterium;GO:0043254|regulation of protein complex assembly;GO:0045087|innate immune response;GO:0050821|protein stabilization;GO:0050829|defense response to Gram-negative bacterium;GO:0060335|positive regulation of interferon-gamma-mediated signaling pathway;GO:0061635|regulation of protein complex stability;GO:0061739|protein lipidation involved in autophagosome assembly;GO:0061762|CAMKK-AMPK signaling cascade;GO:0070431|nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0071222|cellular response to lipopolysaccharide;GO:0071346|cellular response to interferon-gamma;GO:0071902|positive regulation of protein serine/threonine kinase activity;GO:0075044|autophagy of host cells involved in interaction with symbiont;GO:0098586|cellular response to virus;GO:1901098|positive regulation of autophagosome maturation;","GO:0000139|Golgi membrane;GO:0000421|autophagosome membrane;GO:0001891|phagocytic cup;GO:0005739|mitochondrion;GO:0005764|lysosome;GO:0005770|late endosome;GO:0005776|autophagosome;GO:0005789|endoplasmic reticulum membrane;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0030670|phagocytic vesicle membrane;GO:0042995|cell projection;GO:0044754|autolysosome;GO:0045335|phagocytic vesicle;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0019901|protein kinase binding;GO:0043539|protein serine/threonine kinase activator activity;GO:0050700|CARD domain binding;GO:0051434|BH3 domain binding;","K14139","IRGM, LRG47; immunity-related GTPase family M protein [EC:3.6.5.-]"]
["ENSRNOG00000008736",274,22.74930498,24,1.543930516,14.73466891,3.881142738,{"v":2.66371e-66,"d":"2.66E-66"},{"v":3.00919e-65,"d":"3.01E-65"},"up","yes","Slamf8","protein_coding","chr13:85047727-85057211:-","gi|564381809|ref|XP_006250346.1|",1434,0,"PREDICTED: SLAM family member 8 isoform X1 [Rattus norvegicus]","gi|672074763|ref|XM_006250284.2|",2015,0,"PREDICTED: Rattus norvegicus SLAM family member 8 (Slamf8), transcript variant X1, mRNA","Q9D3G2",476,{"v":5e-163,"d":"5.00E-163"},"SLAM family member 8",".",".",".",".","pfam13927","Ig_3","Immunoglobulin domain. This family contains immunoglobulin-like domains.","GO:0002232|leukocyte chemotaxis involved in inflammatory response;GO:0002336|B-1 B cell lineage commitment;GO:0010760|negative regulation of macrophage chemotaxis;GO:0033860|regulation of NAD(P)H oxidase activity;GO:0042742|defense response to bacterium;GO:0043549|regulation of kinase activity;GO:0045577|regulation of B cell differentiation;GO:0060266|negative regulation of respiratory burst involved in inflammatory response;GO:0071466|cellular response to xenobiotic stimulus;GO:0090027|negative regulation of monocyte chemotaxis;GO:0090383|phagosome acidification;GO:1902623|negative regulation of neutrophil migration;GO:2000509|negative regulation of dendritic cell chemotaxis;","GO:0016021|integral component of membrane;","GO:0038023|signaling receptor activity;GO:0042802|identical protein binding;","K16853","SLAMF8, CD353; SLAM family member 8"]
["ENSRNOG00000060241",275,22.83233164,25,1.608260955,14.19690727,3.827504775,{"v":6.10181e-66,"d":"6.10E-66"},{"v":6.86894E-65,"d":"6.87E-65"},"up","yes","ENSRNOG00000060241","protein_coding","chr4:163837399-163865211:-","gi|162417946|ref|NP_001104780.1|",1370,0,"Ly49 inhibitory receptor-like [Rattus norvegicus]","gi|162417945|ref|NM_001111310.1|",1238,0,"Rattus norvegicus hypothetical protein LOC497796 (LOC497796), mRNA","P20937",326,{"v":3e-108,"d":"3.00E-108"},"T-cell surface glycoprotein YE1/48",".",".",".",".","pfam08391","Ly49","Ly49-like protein, N-terminal region. The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000002776",244,20.25850517,12,0.771965258,26.24276799,4.713847993,{"v":2.73061e-65,"d":"2.73E-65"},{"v":3.04709e-64,"d":"3.05E-64"},"up","yes","Sell","protein_coding","chr13:76416915-76436456:+","gi|94400781|ref|NP_062050.3|",1896,0,"L-selectin precursor [Rattus norvegicus]","gi|94400780|ref|NM_019177.3|",1187,0,"Rattus norvegicus selectin L (Sell), mRNA","P30836",729,0,"L-selectin",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0016339|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0033198|response to ATP;GO:0034201|response to oleic acid;GO:0042981|regulation of apoptotic process;GO:0050901|leukocyte tethering or rolling;GO:0055093|response to hyperoxia;GO:0070543|response to linoleic acid;GO:0090023|positive regulation of neutrophil chemotaxis;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;","GO:0002020|protease binding;GO:0005509|calcium ion binding;GO:0050839|cell adhesion molecule binding;GO:0051861|glycolipid binding;GO:0070492|oligosaccharide binding;","K06495","SELL, CD62L; selectin, lymphocyte"]
["ENSRNOG00000004409",327,27.14971799,51,3.280852347,8.275202635,3.04879464,{"v":3.47708E-65,"d":"3.48E-65"},{"v":3.86657E-64,"d":"3.87E-64"},"up","yes","Sash3","protein_coding","chrX:127326859-127341519:+","gi|564400662|ref|XP_006257592.1|",1589,0,"PREDICTED: SAM and SH3 domain-containing protein 3 isoform X1 [Rattus norvegicus]","gi|672088568|ref|XM_006257530.2|",2562,0,"PREDICTED: Rattus norvegicus SAM and SH3 domain containing 3 (Sash3), transcript variant X1, mRNA","Q8K352",592,0,"SAM and SH3 domain-containing protein 3",".",".",".",".","pfam12485","SLY","Lymphocyte signaling adaptor protein. This domain family is found in eukaryotes, and is typically between 144 and 156 amino acids in length. The family is found in association with pfam07647, pfam07653. There is a conserved LGKK sequence motif. SLY contains a Src homology 3 domain and a sterile alpha motif, suggesting that it functions as a signaling adaptor protein in lymphocytes.","GO:0002639|positive regulation of immunoglobulin production;GO:0002726|positive regulation of T cell cytokine production;GO:0002821|positive regulation of adaptive immune response;GO:0030890|positive regulation of B cell proliferation;GO:0032729|positive regulation of interferon-gamma production;GO:0032733|positive regulation of interleukin-10 production;GO:0032743|positive regulation of interleukin-2 production;GO:0032753|positive regulation of interleukin-4 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0042102|positive regulation of T cell proliferation;GO:0043372|positive regulation of CD4-positive, alpha-beta T cell differentiation;GO:0046622|positive regulation of organ growth;GO:0048873|homeostasis of number of cells within a tissue;GO:0051251|positive regulation of lymphocyte activation;","GO:0005634|nucleus;GO:0005737|cytoplasm;",".","K23706","SASH3; SAM and SH3 domain-containing protein 3"]
["ENSRNOG00000003954",989,82.11336726,521,33.51615829,2.449963583,1.292760305,{"v":3.77341e-65,"d":"3.77E-65"},{"v":4.18882e-64,"d":"4.19E-64"},"up","yes","Il2rg","protein_coding","chrX:66392542-66399823:-","gi|149042199|gb|EDL95906.1|",1297,{"v":1E-169,"d":"1.00E-169"},"interleukin 2 receptor, gamma (severe combined immunodeficiency), isoform CRA_b [Rattus norvegicus]","gi|298914770|emb|FQ232752.1|",1289,0,"Rattus norvegicus TL0AEA64YI23 mRNA sequence","P34902",425,{"v":2E-150,"d":"2.00E-150"},"Cytokine receptor common subunit gamma",".",".",".",".","pfam09240","IL6Ra-bind","Interleukin-6 receptor alpha chain, binding. Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.","GO:0010468|regulation of gene expression;GO:0010628|positive regulation of gene expression;GO:0019221|cytokine-mediated signaling pathway;GO:0032831|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0033089|positive regulation of T cell differentiation in thymus;GO:0035723|interleukin-15-mediated signaling pathway;GO:0045579|positive regulation of B cell differentiation;GO:0045621|positive regulation of lymphocyte differentiation;GO:0050766|positive regulation of phagocytosis;","GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0043235|receptor complex;","GO:0004896|cytokine receptor activity;GO:0019955|cytokine binding;GO:0019976|interleukin-2 binding;GO:0042010|interleukin-15 receptor activity;","K05070","IL2RG, CD132; interleukin 2 receptor gamma"]
["ENSRNOG00000013668",911,75.63728774,457,29.39901025,2.572783474,1.363330045,{"v":3.94966e-65,"d":"3.95E-65"},{"v":4.3693e-64,"d":"4.37E-64"},"up","yes","Capg","protein_coding","chr4:104594753-104611856:+","gi|61556900|ref|NP_001013104.1|",1880,0,"macrophage-capping protein [Rattus norvegicus]","gi|672049919|ref|XM_006236666.2|",1187,0,"PREDICTED: Rattus norvegicus capping protein (actin filament), gelsolin-like (Capg), transcript variant X4, mRNA","Q6AYC4",728,0,"Macrophage-capping protein",".",".",".",".","pfam00626","Gelsolin","Gelsolin repeat.","GO:0007417|central nervous system development;GO:0008154|actin polymerization or depolymerization;GO:0030031|cell projection assembly;GO:0051014|actin filament severing;GO:0051016|barbed-end actin filament capping;GO:0071346|cellular response to interferon-gamma;","GO:0001726|ruffle;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005814|centriole;GO:0015629|actin cytoskeleton;GO:0030027|lamellipodium;GO:0042470|melanosome;GO:0045335|phagocytic vesicle;GO:0072686|mitotic spindle;GO:0090543|Flemming body;","GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0019904|protein domain specific binding;GO:0044877|protein-containing complex binding;GO:0051015|actin filament binding;","K10368","CAPG; capping protein (actin filament), gelsolin-like"]
["ENSRNOG00000036829",570,47.3251965,199,12.8017572,3.696773479,1.886266645,{"v":4.455E-65,"d":"4.46E-65"},{"v":4.91981e-64,"d":"4.92E-64"},"up","yes","Nckap1l","protein_coding","chr7:134577482-134622934:+","gi|672060100|ref|XP_008763975.1|",6060,0,"PREDICTED: nck-associated protein 1-like isoform X1 [Rattus norvegicus]","gi|672060099|ref|XM_008765753.1|",4650,0,"PREDICTED: Rattus norvegicus NCK associated protein 1 like (Nckap1l), transcript variant X1, mRNA","Q8K1X4",2302,0,"Nck-associated protein 1-like",".",".",".",".","pfam09735","Nckap1","Membrane-associated apoptosis protein. Expression of this protein was found to be markedly reduced in patients with Alzheimer's disease. It is involved in the regulation of actin polymerization in the brain as part of a WAVE2 signalling complex.","GO:0000902|cell morphogenesis;GO:0001782|B cell homeostasis;GO:0002262|myeloid cell homeostasis;GO:0002687|positive regulation of leukocyte migration;GO:0006935|chemotaxis;GO:0009410|response to xenobiotic stimulus;GO:0016477|cell migration;GO:0030011|maintenance of cell polarity;GO:0030031|cell projection assembly;GO:0030593|neutrophil chemotaxis;GO:0030838|positive regulation of actin filament polymerization;GO:0030866|cortical actin cytoskeleton organization;GO:0030890|positive regulation of B cell proliferation;GO:0032147|activation of protein kinase activity;GO:0032700|negative regulation of interleukin-17 production;GO:0032715|negative regulation of interleukin-6 production;GO:0033630|positive regulation of cell adhesion mediated by integrin;GO:0034101|erythrocyte homeostasis;GO:0035509|negative regulation of myosin-light-chain-phosphatase activity;GO:0042102|positive regulation of T cell proliferation;GO:0042327|positive regulation of phosphorylation;GO:0043029|T cell homeostasis;GO:0043066|negative regulation of apoptotic process;GO:0043318|negative regulation of cytotoxic T cell degranulation;GO:0043372|positive regulation of CD4-positive, alpha-beta T cell differentiation;GO:0043378|positive regulation of CD8-positive, alpha-beta T cell differentiation;GO:0045579|positive regulation of B cell differentiation;GO:0045588|positive regulation of gamma-delta T cell differentiation;GO:0045621|positive regulation of lymphocyte differentiation;GO:0045648|positive regulation of erythrocyte differentiation;GO:0048812|neuron projection morphogenesis;GO:0048821|erythrocyte development;GO:0050853|B cell receptor signaling pathway;GO:0060100|positive regulation of phagocytosis, engulfment;GO:0065003|protein-containing complex assembly;GO:0070358|actin polymerization-dependent cell motility;GO:0090023|positive regulation of neutrophil chemotaxis;GO:1902624|positive regulation of neutrophil migration;GO:1904515|positive regulation of TORC2 signaling;","GO:0005829|cytosol;GO:0031209|SCAR complex;","GO:0005096|GTPase activator activity;GO:0030295|protein kinase activator activity;GO:0044877|protein-containing complex binding;GO:1904841|TORC2 complex binding;","K05750","NCKAP1, NAP125; NCK-associated protein 1"]
["ENSRNOG00000008196",631,52.38982279,242,15.56796604,3.36523234,1.750706114,{"v":4.79523e-65,"d":"4.80E-65"},{"v":5.28641E-64,"d":"5.29E-64"},"up","yes","Parp12","protein_coding","chr4:67839237-67883685:-","gi|392339871|ref|XP_003753925.1|",3495,0,"PREDICTED: poly [ADP-ribose] polymerase 12 isoform X1 [Rattus norvegicus]","gi|672049407|ref|XM_003749716.3|",2870,0,"PREDICTED: Rattus norvegicus poly (ADP-ribose) polymerase family, member 12 (Parp12), transcript variant X1, mRNA","Q8BZ20",1247,0,"Poly [ADP-ribose] polymerase 12",".",".",".",".","pfam00644","PARP","Poly(ADP-ribose) polymerase catalytic domain. Poly(ADP-ribose) polymerase catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The carboxyl-terminal region is the most highly conserved region of the protein. Experiments have shown that a carboxyl 40 kDa fragment is still catalytically active.","GO:0008150|biological_process;GO:0070213|protein auto-ADP-ribosylation;","GO:0005575|cellular_component;","GO:0003674|molecular_function;GO:0003950|NAD+ ADP-ribosyltransferase activity;GO:0046872|metal ion binding;GO:1990404|protein ADP-ribosylase activity;","K15259","PARP7S; poly [ADP-ribose] polymerase 7/11/12/13 [EC:2.4.2.30]"]
["ENSRNOG00000014294",620,51.47652953,235,15.11765297,3.405060932,1.767680615,{"v":8.78889e-65,"d":"8.79E-65"},{"v":9.65585e-64,"d":"9.66E-64"},"up","yes","Ptpn6","protein_coding","chr4:157526035-157550984:-","gi|149049491|gb|EDM01945.1|",3160,0,"protein tyrosine phosphatase, non-receptor type 6, isoform CRA_b [Rattus norvegicus]","gi|71681100|gb|BC099824.1|",1981,0,"Rattus norvegicus protein tyrosine phosphatase, non-receptor type 6, mRNA (cDNA clone MGC:124580 IMAGE:7932620), complete cds","P29351",1208,0,"Tyrosine-protein phosphatase non-receptor type 6","SPAC26F1.10c",151,{"v":4e-37,"d":"4.00E-37"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0002244|hematopoietic progenitor cell differentiation;GO:0002924|negative regulation of humoral immune response mediated by circulating immunoglobulin;GO:0006470|protein dephosphorylation;GO:0008284|positive regulation of cell proliferation;GO:0009611|response to wounding;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0030154|cell differentiation;GO:0030220|platelet formation;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0033277|abortive mitotic cell cycle;GO:0033630|positive regulation of cell adhesion mediated by integrin;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0035556|intracellular signal transduction;GO:0035855|megakaryocyte development;GO:0042130|negative regulation of T cell proliferation;GO:0042267|natural killer cell mediated cytotoxicity;GO:0043407|negative regulation of MAP kinase activity;GO:0043409|negative regulation of MAPK cascade;GO:0045577|regulation of B cell differentiation;GO:0050732|negative regulation of peptidyl-tyrosine phosphorylation;GO:0050853|B cell receptor signaling pathway;GO:0050860|negative regulation of T cell receptor signaling pathway;GO:0051279|regulation of release of sequestered calcium ion into cytosol;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:0070527|platelet aggregation;GO:1905867|epididymis development;GO:2000045|regulation of G1/S transition of mitotic cell cycle;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005911|cell-cell junction;GO:0032991|protein-containing complex;GO:0042105|alpha-beta T cell receptor complex;","GO:0001784|phosphotyrosine residue binding;GO:0004725|protein tyrosine phosphatase activity;GO:0005001|transmembrane receptor protein tyrosine phosphatase activity;GO:0005515|protein binding;GO:0017124|SH3 domain binding;GO:0019901|protein kinase binding;GO:0042169|SH2 domain binding;GO:0046703|natural killer cell lectin-like receptor binding;GO:0050839|cell adhesion molecule binding;GO:0140031|phosphorylation-dependent protein binding;","K05697","PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6 [EC:3.1.3.48]"]
["ENSRNOG00000068984",236,19.59429188,3,0.192991315,101.5293975,6.665753705,{"v":3.1411E-64,"d":"3.14E-64"},{"v":3.41573e-63,"d":"3.42E-63"},"up","yes","Gbp1","protein_coding","chr2:231398163-231432131:+","gi|564301074|ref|XP_006224340.1|",3824,0,"PREDICTED: interferon-induced guanylate-binding protein 1 [Rattus norvegicus]","gi|672016387|ref|XM_006224278.2|",2616,0,"PREDICTED: Rattus norvegicus guanylate binding protein 1, interferon-inducible (Gbp1), transcript variant X1, mRNA","Q5D1D6",855,0,"Guanylate-binding protein 1",".",".",".",".","pfam02263","GBP","Guanylate-binding protein, N-terminal domain. Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.",".",".",".",".","."]
["ENSRNOG00000012965",299,24.8249715,39,2.508887089,9.89481416,3.306672612,{"v":3.78273e-64,"d":"3.78E-64"},{"v":4.10648e-63,"d":"4.11E-63"},"up","yes","Themis2","protein_coding","chr5:144991112-145006400:-","gi|407228396|ref|NP_001258409.1|",3198,0,"protein THEMIS2 [Rattus norvegicus]","gi|407228395|ref|NM_001271480.1|",1974,0,"Rattus norvegicus thymocyte selection associated family member 2 (Themis2), mRNA","Q91YX0",1058,0,"Protein THEMIS2",".",".",".",".","pfam12736","CABIT","Cell-cycle sustaining, positive selection,. The 'CABIT' domain (for 'cysteine-containing, all- in Themis') is found in a newly identified gene family that has three mammalian homologues (Themis, Icb1 and 9130404H23Rik) that encode proteins with two CABIT domains and a highly conserved proline-rich region. In contrast, Fam59A, Fam59B and related proteins from mammals to cnidarians, including the insect Serrano proteins, have a single copy of the CABIT domain, a proline-rich region and often a C-terminal SAM (sterile-motif) domain. Multiple-sequence alignment has predicted that the CABIT domain adopts an all-strand structure with at least 12 strands, ie a dyad of six-stranded beta-barrel units. The CABIT domain contains a nearly absolutely conserved cysteine residue which is likely to be central to its function. CABIT domain proteins function downstream of tyrosine kinase signalling and interact with GRB2.","GO:0050852|T cell receptor signaling pathway;GO:0050864|regulation of B cell activation;","GO:0005634|nucleus;GO:0005737|cytoplasm;",".",".","."]
["ENSRNOG00000069878",232,19.26218524,9,0.578973944,33.26952008,5.05612915,{"v":1.74387E-63,"d":"1.74E-63"},{"v":1.87719e-62,"d":"1.88E-62"},"up","yes","ENSRNOG00000069878","protein_coding","chr13:85977035-85994718:-","gi|755496152|ref|XP_011237197.1|",1914,0,"PREDICTED: LOW QUALITY PROTEIN: gamma-interferon-inducible protein 16-like [Mus musculus]","gi|298891459|emb|FQ227444.1|",950,0,"Rattus norvegicus TL0AEA13YF07 mRNA sequence","P0DOV2",353,{"v":1E-107,"d":"1.00E-107"},"Interferon-activable protein 204",".",".",".",".","pfam02760","HIN","HIN-200/IF120x domain. This domain has no know function. It is found in one or two copies per protein, and is found associated with the PAAD/DAPIN domain pfam02758.",".",".",".",".","."]
["ENSRNOG00000013526",439,36.44870397,118,7.590991706,4.801573415,2.263507236,{"v":2.23423E-63,"d":"2.23E-63"},{"v":2.38894E-62,"d":"2.39E-62"},"up","yes","Rassf4","protein_coding","chr4:149897543-149932411:-","gi|66730441|ref|NP_001019446.1|",1414,0,"ras association domain-containing protein 4 [Rattus norvegicus]","gi|66730440|ref|NM_001024275.1|",2412,0,"Rattus norvegicus Ras association domain family member 4 (Rassf4), mRNA","Q566C5",549,0,"Ras association domain-containing protein 4",".",".",".",".","pfam00788","RA","Ras association (RalGDS/AF-6) domain. RasGTP effectors (in cases of AF6, canoe and RalGDS); putative RasGTP effectors in other cases. Recent evidence (not yet in MEDLINE) shows that some RA domains do NOT bind RasGTP. Predicted structure similar to that determined, and that of the RasGTP-binding domain of Raf kinase.","GO:0007165|signal transduction;",".",".","K09851","RASSF2_4; Ras association domain-containing protein 2/4"]
["ENSRNOG00000039891",342,28.3951179,63,4.052817606,7.006265927,2.808645748,{"v":6.0472E-63,"d":"6.05E-63"},{"v":6.39115E-62,"d":"6.39E-62"},"up","yes","Adgrg5","protein_coding","chr19:10079375-10097214:-","gi|672084140|ref|XP_008770528.1|",2552,0,"PREDICTED: probable G-protein coupled receptor 114 isoform X5 [Rattus norvegicus]","gi|157817834|ref|NM_001107410.1|",2766,0,"Rattus norvegicus adhesion G protein-coupled receptor G5 (Adgrg5), mRNA","Q3V3Z3",858,0,"Adhesion G-protein coupled receptor G5",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0007166|cell surface receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;","GO:0005887|integral component of plasma membrane;","GO:0004930|G protein-coupled receptor activity;","K08459","ADGRG5, GPR114; adhesion G-protein coupled receptor G5"]
["ENSRNOG00000013267",966,80.20375407,514,33.06584523,2.425577012,1.278327986,{"v":1.31526E-62,"d":"1.32E-62"},{"v":1.38549E-61,"d":"1.39E-61"},"up","yes","Helz2","protein_coding","chr3:168338813-168353159:-","gi|765826399|ref|NP_001292205.1|",15424,0,"peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein [Rattus norvegicus]","gi|765826398|ref|NM_001305276.1|",10042,0,"Rattus norvegicus helicase with zinc finger 2, transcriptional coactivator (Helz2), mRNA","E9QAM5",5251,0,"Helicase with zinc finger domain 2","SPAC16C9.06c",194,{"v":5e-49,"d":"5.00E-49"},"COG1112","pfam13087","AAA_12","AAA domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.","GO:0032508|DNA duplex unwinding;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0090501|RNA phosphodiester bond hydrolysis;","GO:0005634|nucleus;","GO:0003723|RNA binding;GO:0004540|ribonuclease activity;GO:0030374|nuclear receptor transcription coactivator activity;GO:0043139|5'-3' DNA helicase activity;","K25165","HELZ2; helicase with zinc finger domain 2 [EC:3.6.4.-]"]
["ENSRNOG00000010661",309,25.6552381,47,3.023530595,8.485192162,3.084947332,{"v":2.30863e-62,"d":"2.31E-62"},{"v":2.40417E-61,"d":"2.40E-61"},"up","yes","Gzmk","protein_coding","chr2:44840811-44848894:-","gi|149059362|gb|EDM10369.1|",1280,{"v":3e-174,"d":"3.00E-174"},"granzyme K [Rattus norvegicus]","gi|451958180|ref|NM_017119.2|",782,0,"Rattus norvegicus granzyme K (Gzmk), mRNA","P49864",494,{"v":3e-174,"d":"3.00E-174"},"Granzyme K","mlr3307",89,{"v":5e-19,"d":"5.00E-19"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;",".","GO:0004252|serine-type endopeptidase activity;GO:0008236|serine-type peptidase activity;","K08663","GZMK; granzyme K [EC:3.4.21.-]"]
["ENSRNOG00000047414",308,25.57221144,47,3.023530595,8.457731993,3.080270845,{"v":4.41027E-62,"d":"4.41E-62"},{"v":4.57046e-61,"d":"4.57E-61"},"up","yes","AABR07058479.1","protein_coding","chr7:109157933-109175591:-","gi|672022243|ref|XP_008774771.1|",1432,0,"PREDICTED: LOW QUALITY PROTEIN: apolipoprotein L2-like isoform X1 [Rattus norvegicus]","gi|672059741|ref|XM_008765649.1|",1287,0,"PREDICTED: Rattus norvegicus similar to RIKEN cDNA 2210421G13 (RGD1565356), transcript variant X2, mRNA","O95236",201,{"v":2E-55,"d":"2.00E-55"},"Apolipoprotein L3",".",".",".",".","pfam05461","ApoL","Apolipoprotein L. Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.",".",".",".",".","."]
["ENSRNOG00000021424",250,20.75666513,20,1.286608764,16.13284917,4.011929346,{"v":6.70231e-62,"d":"6.70E-62"},{"v":6.92331e-61,"d":"6.92E-61"},"up","yes","Cd300lf","protein_coding","chr10:100359943-100376041:-","gi|68341985|ref|NP_001020282.1|",1394,0,"CMRF35-like molecule 1 precursor [Rattus norvegicus]","gi|68341984|ref|NM_001025111.1|",1786,0,"Rattus norvegicus Cd300 molecule-like family member F (Cd300lf), mRNA","Q566E6",541,0,"CMRF35-like molecule 1",".",".",".",".","pfam15330","SIT","SHP2-interacting transmembrane adaptor protein, SIT. SIT, or SHP2-interacting transmembrane adaptor protein, is a disulfide-linked dimer that regulates human T Cell activation.","GO:0030316|osteoclast differentiation;GO:0033004|negative regulation of mast cell activation;GO:0034125|negative regulation of MyD88-dependent toll-like receptor signaling pathway;GO:0035666|TRIF-dependent toll-like receptor signaling pathway;GO:0035772|interleukin-13-mediated signaling pathway;GO:0046718|viral entry into host cell;GO:1902216|positive regulation of interleukin-4-mediated signaling pathway;GO:2000426|negative regulation of apoptotic cell clearance;GO:2000427|positive regulation of apoptotic cell clearance;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0001618|virus receptor activity;GO:0001786|phosphatidylserine binding;GO:0004888|transmembrane signaling receptor activity;GO:0005136|interleukin-4 receptor binding;GO:0042802|identical protein binding;GO:0097001|ceramide binding;","K20395","CD300B_D_F; CO300B/D/F antigen"]
["ENSRNOG00000036703",532,44.1701834,183,11.77247019,3.751989404,1.907655753,{"v":9.21996e-62,"d":"9.22E-62"},{"v":9.4933e-61,"d":"9.49E-61"},"up","yes","Itgax","protein_coding","chr1:182719609-182740698:+","gi|293356227|ref|XP_574569.3|",6104,0,"PREDICTED: integrin alpha-X isoform X1 [Rattus norvegicus]","gi|672038695|ref|XM_574569.6|",4444,0,"PREDICTED: Rattus norvegicus integrin, alpha X (Itgax), transcript variant X1, mRNA","Q9QXH4",2026,0,"Integrin alpha-X",".",".",".",".","pfam08441","Integrin_alpha2","Integrin alpha. This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.","GO:0007229|integrin-mediated signaling pathway;GO:0008284|positive regulation of cell proliferation;GO:0010628|positive regulation of gene expression;GO:0030335|positive regulation of cell migration;GO:0031643|positive regulation of myelination;GO:0034113|heterotypic cell-cell adhesion;GO:0045766|positive regulation of angiogenesis;GO:0051607|defense response to virus;GO:1905956|positive regulation of endothelial tube morphogenesis;","GO:0008305|integrin complex;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;","GO:0030971|receptor tyrosine kinase binding;GO:0046872|metal ion binding;","K06462","ITGAX, CD11c; integrin alpha X"]
["ENSRNOG00000021644",388,32.21434428,92,5.918400313,5.443083026,2.444424042,{"v":2.05027E-61,"d":"2.05E-61"},{"v":2.1009E-60,"d":"2.10E-60"},"up","yes","Slc15a3","protein_coding","chr1:207492365-207507157:+","gi|21326469|ref|NP_647557.1|",2430,0,"solute carrier family 15 member 3 [Rattus norvegicus]","gi|21326468|ref|NM_139341.1|",1952,0,"Rattus norvegicus solute carrier family 15 member 3 (Slc15a3), mRNA","Q924V4",940,0,"Solute carrier family 15 member 3","SPBC13A2.04c",90.9,{"v":3e-18,"d":"3.00E-18"},"COG3104","pfam00854","PTR2","POT family. The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.","GO:0015031|protein transport;GO:0015835|peptidoglycan transport;GO:0030163|protein catabolic process;GO:0045087|innate immune response;GO:0070434|positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0140206|dipeptide import across plasma membrane;","GO:0005765|lysosomal membrane;GO:0010008|endosome membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0005427|proton-dependent oligopeptide secondary active transmembrane transporter activity;GO:0015293|symporter activity;GO:0015647|peptidoglycan transmembrane transporter activity;GO:0071916|dipeptide transmembrane transporter activity;","K14638","SLC15A3_4, PHT; solute carrier family 15 (peptide/histidine transporter), member 3/4"]
["ENSRNOG00000050974",246,20.42455849,21,1.350939202,15.11878437,3.918270239,{"v":4.51726e-60,"d":"4.52E-60"},{"v":4.57747E-59,"d":"4.58E-59"},"up","yes","AABR07030773.1","protein_coding","chr10:100253624-100258323:-","gi|269973887|ref|NP_001161756.1|",999,{"v":3E-134,"d":"3.00E-134"},"immune activating receptor CD300d2 precursor [Rattus norvegicus]","gi|269973886|ref|NM_001168284.1|",630,0,"Rattus norvegicus similar to dendritic cell-derived immunoglobulin(Ig)-like receptor 1, DIgR1 - mouse (RGD1561778), mRNA","Q7TSN2",251,{"v":2e-81,"d":"2.00E-81"},"CMRF35-like molecule",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000057092",216,17.93375867,4,0.257321753,69.69390843,6.122960658,{"v":5.41526e-60,"d":"5.42E-60"},{"v":5.47876e-59,"d":"5.48E-59"},"up","yes","Slfn4","protein_coding","chr10:67994632-68018138:+","gi|16758506|ref|NP_446139.1|",3009,0,"schlafen 4 [Rattus norvegicus]","gi|672068330|ref|XM_008767933.1|",5279,0,"PREDICTED: Rattus norvegicus schlafen 3 (Slfn3), transcript variant X1, mRNA","Q8IYM2",446,{"v":1e-137,"d":"1.00E-137"},"Schlafen family member 12",".",".",".",".","pfam04326","AAA_4","Divergent AAA domain. This family is related to the pfam00004 family, and presumably has the same function (ATP-binding).","GO:0009617|response to bacterium;GO:0048286|lung alveolus development;","GO:0016021|integral component of membrane;",".","K24457","SLFN12, SLFN12L; schlafen family member 12"]
["ENSRNOG00000016978",227,18.84705194,13,0.836295696,22.53634931,4.494181925,{"v":9.69688e-60,"d":"9.70E-60"},{"v":9.79508e-59,"d":"9.80E-59"},"up","yes","ENSRNOG00000016978","protein_coding","chr1:181702503-181705835:+","gi|68163457|ref|NP_001020172.1|",1039,{"v":7e-131,"d":"7.00E-131"},"transmembrane protein C16orf54 homolog [Rattus norvegicus]","gi|68163456|ref|NM_001025001.1|",2149,0,"Rattus norvegicus hypothetical protein LOC308990 (LOC308990), mRNA","Q5BK39",404,{"v":2E-132,"d":"2.00E-132"},"Transmembrane protein C16orf54 homolog",".",".",".",".","pfam06398","Pex24p","Integral peroxisomal membrane peroxin. Peroxisomes play diverse roles in the cell, compartmentalising many activities related to lipid metabolizm and functioning in the decomposition of toxic hydrogen peroxide. Sequence similarity was identified between two hypothetical proteins and the peroxin integral membrane protein Pex24p.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000003745",330,27.39879797,63,4.052817606,6.760432035,2.757115447,{"v":1.1119E-59,"d":"1.11E-59"},{"v":1.12139e-58,"d":"1.12E-58"},"up","yes","Atf3","protein_coding","chr13:102751321-102764631:-","gi|537158431|gb|ERE73051.1|",881,{"v":8e-112,"d":"8.00E-112"},"cyclic AMP-dependent transcription factor ATF-3-like protein [Cricetulus griseus]","gi|401709968|ref|NM_012912.2|",1888,0,"Rattus norvegicus activating transcription factor 3 (Atf3), mRNA","P29596",342,{"v":9e-113,"d":"9.00E-113"},"Cyclic AMP-dependent transcription factor ATF-3",".",".",".",".","pfam00170","bZIP_1","bZIP transcription factor. The Pfam entry includes the basic region and the leucine zipper region.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001709|cell fate determination;GO:0006094|gluconeogenesis;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008284|positive regulation of cell proliferation;GO:0010628|positive regulation of gene expression;GO:0030968|endoplasmic reticulum unfolded protein response;GO:0034198|cellular response to amino acid starvation;GO:0035914|skeletal muscle cell differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:1903984|positive regulation of TRAIL-activated apoptotic signaling pathway;GO:1990440|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:1990622|CHOP-ATF3 complex;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0046982|protein heterodimerization activity;GO:1990837|sequence-specific double-stranded DNA binding;","K09032","ATF3, LRF1; activating transcription factor 3"]
["ENSRNOG00000004084",867,71.98411468,446,28.69137543,2.508911253,1.327061439,{"v":1.2428e-59,"d":"1.24E-59"},{"v":1.25143E-58,"d":"1.25E-58"},"up","yes","Lratd1","protein_coding","chr6:36913469-36922319:-","gi|148666046|gb|EDK98462.1|",1515,0,"expressed sequence AW125753, isoform CRA_b, partial [Mus musculus]","gi|672055795|ref|XM_006239901.2|",4071,0,"PREDICTED: Rattus norvegicus family with sequence similarity 84, member A (Fam84a), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam04970","LRAT","Lecithin retinol acyltransferase. The full-length members of this family are representatives of a novel class II tumor-suppressor family, designated as H-REV107-like. This domain is the catalytic N-terminal proline-rich region of the protein. The downstream region is a putative C-terminal transmembrane domain which is found to be crucial for cellular localisation, but not necessary for the enzyme activity. H-REV107-like proteins are homologous to lecithin retinol acyltransferase (LRAT), an enzyme that catalyses the transfer of the sn-1 acyl group of phosphatidylcholine to all-trans-retinol and forming a retinyl ester.","GO:0000902|cell morphogenesis;GO:0048870|cell motility;",".",".","K22805","FAM84A, NSE1; protein FAM84A"]
["ENSRNOG00000001314",1014,84.18903377,570,36.66834977,2.295959167,1.199096984,{"v":1.58275e-59,"d":"1.58E-59"},{"v":1.59124E-58,"d":"1.59E-58"},"up","yes","Fam20c","protein_coding","chr12:15826871-15884543:-","gi|59676599|ref|NP_001012238.1|",2766,0,"extracellular serine/threonine protein kinase FAM20C [Rattus norvegicus]","gi|59676598|ref|NM_001012238.1|",2658,0,"Rattus norvegicus family with sequence similarity 20, member C (Fam20c), mRNA","Q5MJS3",1043,0,"Extracellular serine/threonine protein kinase FAM20C",".",".",".",".","pfam06702","DUF1193","Protein of unknown function (DUF1193). This family represents the C-terminus of several hypothetical eukaryotic proteins of unknown function. Family members contain two conserved motifs: DRHHYE and QCC, as well as a number of conserved cysteine residues.","GO:0001501|skeletal system development;GO:0006468|protein phosphorylation;GO:0030501|positive regulation of bone mineralization;GO:0031214|biomineral tissue development;GO:0036179|osteoclast maturation;GO:0040036|regulation of fibroblast growth factor receptor signaling pathway;GO:0045669|positive regulation of osteoblast differentiation;GO:0046034|ATP metabolic process;GO:0051174|regulation of phosphorus metabolic process;GO:0070166|enamel mineralization;GO:0071895|odontoblast differentiation;GO:0097187|dentinogenesis;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;","GO:0004674|protein serine/threonine kinase activity;GO:0005509|calcium ion binding;GO:0016773|phosphotransferase activity, alcohol group as acceptor;GO:0030145|manganese ion binding;","K21958","FAM20C; extracellular serine/threonine protein kinase FAM20C [EC:2.7.11.1]"]
["ENSRNOG00000070531",220,18.26586532,10,0.643304382,28.39381455,4.827504775,{"v":1.59778e-59,"d":"1.60E-59"},{"v":1.60383e-58,"d":"1.60E-58"},"up","yes","Ltb","protein_coding","chr20:3627537-3629381:-","gi|47059114|ref|NP_997672.1|",1302,{"v":6e-177,"d":"6.00E-177"},"lymphotoxin-beta [Rattus norvegicus]","gi|672085855|ref|XM_008772776.1|",1167,0,"PREDICTED: Rattus norvegicus lymphotoxin-beta (LOC103694381), mRNA","P41155",449,{"v":5e-156,"d":"5.00E-156"},"Lymphotoxin-beta",".",".",".",".","pfam00229","TNF","TNF(tumor Necrosis Factor) family.",".",".",".",".","."]
["ENSRNOG00000006932",387,32.13131762,96,6.175722066,5.202843859,2.379300412,{"v":2.01713e-59,"d":"2.02E-59"},{"v":2.02159e-58,"d":"2.02E-58"},"up","yes","AABR07029272.1","protein_coding","chr10:18827239-19244808:-","gi|117553625|ref|NP_203538.2|",9396,0,"dedicator of cytokinesis protein 2 [Mus musculus]","gi|459683823|ref|NM_033374.3|",4788,0,"Mus musculus dedicator of cyto-kinesis 2 (Dock2), mRNA","Q8C3J5",3619,0,"Dedicator of cytokinesis protein 2",".",".",".",".","pfam14429","DOCK-C2","C2 domain in Dock180 and Zizimin proteins. The Dock180/Dock1 and Zizimin proteins are atypical GTP/GDP exchange factors for the small GTPases Rac and Cdc42 and are implicated cell-migration and phagocytosis. Across all Dock180 proteins, two regions are conserved: C-terminus termed CZH2 or DHR2 (or the Dedicator of cytokinesis) whereas CZH1/DHR1 contain a new family of the C2 domain.",".",".",".",".","."]
["ENSRNOG00000042825",464,38.52437048,145,9.327913537,4.130009389,2.046145061,{"v":3.79184E-59,"d":"3.79E-59"},{"v":3.77068e-58,"d":"3.77E-58"},"up","yes","Cd300le","protein_coding","chr10:100271036-100280299:-","gi|320498033|ref|NP_001189392.1|",945,{"v":3e-126,"d":"3.00E-126"},"Cd300 molecule-like family member E precursor [Rattus norvegicus]","gi|320498032|ref|NM_001202463.1|",691,0,"Rattus norvegicus Cd300 molecule-like family member E (Cd300le), mRNA","Q6SJQ5",303,{"v":1e-101,"d":"1.00E-101"},"CMRF35-like molecule 3",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004888|transmembrane signaling receptor activity;","K20395","CD300B_D_F; CO300B/D/F antigen"]
["ENSRNOG00000018971",764,63.43236864,367,23.60927081,2.686756789,1.425865731,{"v":1.18681E-58,"d":"1.19E-58"},{"v":1.16928E-57,"d":"1.17E-57"},"up","yes","Mob3a","protein_coding","chr7:9010587-9027879:+","gi|157823747|ref|NP_001102204.1|",1181,{"v":2e-154,"d":"2.00E-154"},"MOB kinase activator 3A [Rattus norvegicus]","gi|197927363|ref|NM_001108734.2|",1720,0,"Rattus norvegicus MOB kinase activator 3A (Mob3a), mRNA","Q8BSU7",454,{"v":3e-154,"d":"3.00E-154"},"MOB kinase activator 3A",".",".",".",".","pfam03637","Mob1_phocein","Mob1/phocein family. Mob1 is an essential Saccharomyces cerevisiae protein, identified from a two-hybrid screen, that binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Mob1 contains no known structural motifs; however MOB1 is a member of a conserved gene family and shares sequence similarity with a nonessential yeast gene, MOB2. Mob1 is a phosphoprotein in vivo and a substrate for the Mps1p kinase in vitro. Conditional alleles of MOB1 cause a late nuclear division arrest at restrictive temperature. This family also includes phocein, a rat protein that by yeast two hybrid interacts with striatin.","GO:0001934|positive regulation of protein phosphorylation;GO:0007165|signal transduction;GO:0016310|phosphorylation;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0016301|kinase activity;GO:0030295|protein kinase activator activity;",".","."]
["ENSRNOG00000053200",489,40.600037,166,10.67885274,3.801909998,1.92672438,{"v":1.18252E-57,"d":"1.18E-57"},{"v":1.15438e-56,"d":"1.15E-56"},"up","yes","Dock10","protein_coding","chr9:81843604-82101525:-","gi|392342442|ref|XP_003754589.1|",11191,0,"PREDICTED: dedicator of cytokinesis protein 10 isoform X13 [Rattus norvegicus]","gi|672024204|ref|XM_003754541.3|",7709,0,"PREDICTED: Rattus norvegicus dedicator of cytokinesis 10 (Dock10), transcript variant X13, mRNA","Q8BZN6",4110,0,"Dedicator of cytokinesis protein 10",".",".",".",".","pfam06920","Ded_cyto","Dedicator of cytokinesis. This family represents a conserved region approximately 200 residues long within a number of eukaryotic dedicator of cytokinesis proteins. These are potential guanine nucleotide exchange factors, which activate some small GTPases by exchanging bound GDP for free GTP.","GO:0001782|B cell homeostasis;GO:0002315|marginal zone B cell differentiation;GO:0030334|regulation of cell migration;GO:0043547|positive regulation of GTPase activity;GO:0060997|dendritic spine morphogenesis;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0043197|dendritic spine;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0031267|small GTPase binding;","K21853","DOCK9_10_11; dedicator of cytokinesis protein 9/10/11"]
["ENSRNOG00000017277",340,28.22906458,73,4.696121987,6.011143802,2.587639533,{"v":1.6581E-57,"d":"1.66E-57"},{"v":1.61617e-56,"d":"1.62E-56"},"up","yes","Igsf6","protein_coding","chr1:175610167-175620722:-","gi|149068040|gb|EDM17592.1|",1123,{"v":2e-145,"d":"2.00E-145"},"immunoglobulin superfamily, member 6 [Rattus norvegicus]","gi|451958097|ref|NM_133542.2|",2223,0,"Rattus norvegicus immunoglobulin superfamily, member 6 (Igsf6), mRNA","Q9Z0K5",434,{"v":1e-145,"d":"1.00E-145"},"Immunoglobulin superfamily member 6",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000006952",538,44.66834336,202,12.99474851,3.437414992,1.781324036,{"v":4.85018e-57,"d":"4.85E-57"},{"v":4.67761e-56,"d":"4.68E-56"},"up","yes","Prex1","protein_coding","chr3:155306950-155456688:-","gi|208973288|ref|NP_001129190.1|",8373,0,"phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [Rattus norvegicus]","gi|208973287|ref|NM_001135718.1|",5435,0,"Rattus norvegicus phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 (Prex1), mRNA","Q69ZK0",3115,0,"Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein",".",".",".",".","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0030217|T cell differentiation;GO:0030335|positive regulation of cell migration;GO:0030593|neutrophil chemotaxis;GO:0030833|regulation of actin filament polymerization;GO:0035556|intracellular signal transduction;GO:0043547|positive regulation of GTPase activity;GO:0045785|positive regulation of cell adhesion;GO:0050773|regulation of dendrite development;GO:0072593|reactive oxygen species metabolic process;GO:1900026|positive regulation of substrate adhesion-dependent cell spreading;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0030426|growth cone;GO:0043198|dendritic shaft;GO:0048471|perinuclear region of cytoplasm;","GO:0003674|molecular_function;GO:0005085|guanyl-nucleotide exchange factor activity;GO:0005543|phospholipid binding;","K12365","PREX1; phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchanger 1 protein"]
["ENSRNOG00000009211",251,20.83969179,28,1.801252269,11.56955755,3.532261788,{"v":4.90565E-57,"d":"4.91E-57"},{"v":4.72398E-56,"d":"4.72E-56"},"up","yes","C3ar1","protein_coding","chr4:156075389-156084701:-","gi|564348849|ref|XP_006237376.1|",2466,0,"PREDICTED: C3a anaphylatoxin chemotactic receptor isoform X1 [Rattus norvegicus]","gi|14091739|ref|NM_032060.1|",1978,0,"Rattus norvegicus complement component 3a receptor 1 (C3ar1), mRNA","O55197",945,0,"C3a anaphylatoxin chemotactic receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0002430|complement receptor mediated signaling pathway;GO:0002462|tolerance induction to nonself antigen;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0008217|regulation of blood pressure;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0010759|positive regulation of macrophage chemotaxis;GO:0030335|positive regulation of cell migration;GO:0045766|positive regulation of angiogenesis;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0051482|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway;GO:0072126|positive regulation of glomerular mesangial cell proliferation;GO:0090023|positive regulation of neutrophil chemotaxis;GO:2000573|positive regulation of DNA biosynthetic process;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0001850|complement component C3a binding;GO:0004875|complement receptor activity;GO:0004876|complement component C3a receptor activity;GO:0004930|G protein-coupled receptor activity;","K04009","C3AR1; C3a anaphylatoxin chemotactic receptor"]
["ENSRNOG00000003480",249,20.67363847,28,1.801252269,11.47736984,3.520720166,{"v":1.86216e-56,"d":"1.86E-56"},{"v":1.7798e-55,"d":"1.78E-55"},"up","yes","Aim2","protein_coding","chr13:85866284-85906975:+","gi|293341479|ref|XP_001057147.2|",1564,0,"PREDICTED: interferon-inducible protein AIM2 [Rattus norvegicus]","gi|672027384|ref|XM_008763565.1|",1858,0,"PREDICTED: Rattus norvegicus absent in melanoma 2 (Aim2), transcript variant X4, mRNA","Q91VJ1",507,{"v":1E-174,"d":"1.00E-174"},"Interferon-inducible protein AIM2",".",".",".",".","pfam02760","HIN","HIN-200/IF120x domain. This domain has no know function. It is found in one or two copies per protein, and is found associated with the PAAD/DAPIN domain pfam02758.","GO:0002218|activation of innate immune response;GO:0002230|positive regulation of defense response to virus by host;GO:0008150|biological_process;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0032731|positive regulation of interleukin-1 beta production;GO:0033209|tumor necrosis factor-mediated signaling pathway;GO:0035458|cellular response to interferon-beta;GO:0044546|NLRP3 inflammasome complex assembly;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0070269|pyroptosis;GO:0071466|cellular response to xenobiotic stimulus;GO:1904270|pyroptosome complex assembly;GO:2001056|positive regulation of cysteine-type endopeptidase activity;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;GO:0097169|AIM2 inflammasome complex;","GO:0003674|molecular_function;GO:0003690|double-stranded DNA binding;GO:0042802|identical protein binding;","K12966","AIM2; absent in melanoma 2"]
["ENSRNOG00000008180",1090,90.49905997,654,42.07210657,2.151046557,1.10503875,{"v":3.00985E-56,"d":"3.01E-56"},{"v":2.86389E-55,"d":"2.86E-55"},"up","yes","Lyn","protein_coding","chr5:16639466-16756868:+","gi|674050187|ref|XP_008831300.1|",2796,0,"PREDICTED: tyrosine-protein kinase Lyn isoform X1 [Nannospalax galili]","gi|162287329|ref|NM_030857.2|",3430,0,"Rattus norvegicus LYN proto-oncogene, Src family tyrosine kinase (Lyn), transcript variant 1, mRNA","Q07014",1068,0,"Tyrosine-protein kinase Lyn",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001782|B cell homeostasis;GO:0001817|regulation of cytokine production;GO:0001933|negative regulation of protein phosphorylation;GO:0001934|positive regulation of protein phosphorylation;GO:0002250|adaptive immune response;GO:0002431|Fc receptor mediated stimulatory signaling pathway;GO:0002513|tolerance induction to self antigen;GO:0002553|histamine secretion by mast cell;GO:0002576|platelet degranulation;GO:0002762|negative regulation of myeloid leukocyte differentiation;GO:0002768|immune response-regulating cell surface receptor signaling pathway;GO:0002774|Fc receptor mediated inhibitory signaling pathway;GO:0002902|regulation of B cell apoptotic process;GO:0006468|protein phosphorylation;GO:0006974|cellular response to DNA damage stimulus;GO:0006991|response to sterol depletion;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0009410|response to xenobiotic stimulus;GO:0009636|response to toxic substance;GO:0009725|response to hormone;GO:0009743|response to carbohydrate;GO:0010976|positive regulation of neuron projection development;GO:0014003|oligodendrocyte development;GO:0014070|response to organic cyclic compound;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0030097|hemopoiesis;GO:0030154|cell differentiation;GO:0030218|erythrocyte differentiation;GO:0030335|positive regulation of cell migration;GO:0030889|negative regulation of B cell proliferation;GO:0031175|neuron projection development;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0031668|cellular response to extracellular stimulus;GO:0032868|response to insulin;GO:0033003|regulation of mast cell activation;GO:0033628|regulation of cell adhesion mediated by integrin;GO:0034136|negative regulation of toll-like receptor 2 signaling pathway;GO:0034142|toll-like receptor 4 signaling pathway;GO:0034144|negative regulation of toll-like receptor 4 signaling pathway;GO:0034605|cellular response to heat;GO:0035556|intracellular signal transduction;GO:0042327|positive regulation of phosphorylation;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0043200|response to amino acid;GO:0043304|regulation of mast cell degranulation;GO:0043407|negative regulation of MAP kinase activity;GO:0043434|response to peptide hormone;GO:0043552|positive regulation of phosphatidylinositol 3-kinase activity;GO:0045087|innate immune response;GO:0045646|regulation of erythrocyte differentiation;GO:0046777|protein autophosphorylation;GO:0048678|response to axon injury;GO:0050727|regulation of inflammatory response;GO:0050853|B cell receptor signaling pathway;GO:0050855|regulation of B cell receptor signaling pathway;GO:0051272|positive regulation of cellular component movement;GO:0051279|regulation of release of sequestered calcium ion into cytosol;GO:0060252|positive regulation of glial cell proliferation;GO:0060369|positive regulation of Fc receptor mediated stimulatory signaling pathway;GO:0070304|positive regulation of stress-activated protein kinase signaling cascade;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0070447|positive regulation of oligodendrocyte progenitor proliferation;GO:0070667|negative regulation of mast cell proliferation;GO:0070668|positive regulation of mast cell proliferation;GO:0071300|cellular response to retinoic acid;GO:0090025|regulation of monocyte chemotaxis;GO:0090330|regulation of platelet aggregation;GO:0097028|dendritic cell differentiation;GO:1902532|negative regulation of intracellular signal transduction;GO:1902961|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process;GO:2000670|positive regulation of dendritic cell apoptotic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005758|mitochondrial intermembrane space;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005912|adherens junction;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0030061|mitochondrial crista;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0031966|mitochondrial membrane;GO:0032991|protein-containing complex;GO:0034666|integrin alpha2-beta1 complex;GO:0043231|intracellular membrane-bounded organelle;GO:0045121|membrane raft;GO:0048471|perinuclear region of cytoplasm;GO:0098978|glutamatergic synapse;GO:0099091|postsynaptic specialization, intracellular component;","GO:0004672|protein kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0005102|signaling receptor binding;GO:0005161|platelet-derived growth factor receptor binding;GO:0005178|integrin binding;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0016301|kinase activity;GO:0017124|SH3 domain binding;GO:0019899|enzyme binding;GO:0031625|ubiquitin protein ligase binding;GO:0043015|gamma-tubulin binding;GO:0043208|glycosphingolipid binding;GO:0044325|ion channel binding;GO:0044877|protein-containing complex binding;GO:0046875|ephrin receptor binding;GO:0051219|phosphoprotein binding;GO:0097110|scaffold protein binding;GO:0140031|phosphorylation-dependent protein binding;","K05854","LYN; tyrosine-protein kinase Lyn [EC:2.7.10.2]"]
["ENSRNOG00000056783",204,16.93743875,3,0.192991315,87.76269951,6.455535997,{"v":3.04729e-56,"d":"3.05E-56"},{"v":2.8952E-55,"d":"2.90E-55"},"up","yes","Cd69","protein_coding","chr4:162725446-162733542:-","gi|61097910|ref|NP_599154.1|",873,{"v":6e-108,"d":"6.00E-108"},"early activation antigen CD69 [Rattus norvegicus]","gi|61097909|ref|NM_134327.1|",1474,0,"Rattus norvegicus Cd69 molecule (Cd69), mRNA","P37217",275,{"v":1E-84,"d":"1.00E-84"},"Early activation antigen CD69",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0001867|complement activation, lectin pathway;GO:0071466|cellular response to xenobiotic stimulus;","GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0032991|protein-containing complex;","GO:0005509|calcium ion binding;GO:0042802|identical protein binding;","K06502","CD69; CD69 antigen"]
["ENSRNOG00000027990",564,46.82703654,225,14.47434859,3.235174021,1.693843317,{"v":8.95827e-56,"d":"8.96E-56"},{"v":8.46088e-55,"d":"8.46E-55"},"up","yes","Crip1","protein_coding","chr6:132226746-132234620:+","gi|148686610|gb|EDL18557.1|",578,{"v":2E-73,"d":"2.00E-73"},"cysteine-rich protein 1 (intestinal), isoform CRA_a [Mus musculus]","gi|349585430|ref|NM_001244867.1|",383,0,"Rattus norvegicus cysteine rich protein 1 (Crip1), transcript variant 1, mRNA","P63255",161,{"v":9e-50,"d":"9.00E-50"},"Cysteine-rich protein 1",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.","GO:0006955|immune response;GO:0008630|intrinsic apoptotic signaling pathway in response to DNA damage;GO:0010033|response to organic substance;GO:0010043|response to zinc ion;GO:0010468|regulation of gene expression;GO:0060741|prostate gland stromal morphogenesis;GO:0071236|cellular response to antibiotic;GO:0071493|cellular response to UV-B;","GO:0005737|cytoplasm;","GO:0008270|zinc ion binding;GO:0042277|peptide binding;","K24412","CRIP1, CRP1; cysteine-rich protein 1"]
["ENSRNOG00000016575",641,53.2200894,285,18.33417488,2.902780722,1.537435594,{"v":3.74661e-55,"d":"3.75E-55"},{"v":3.48708e-54,"d":"3.49E-54"},"up","yes","Tnfrsf1b","protein_coding","chr5:157070642-157104206:-","gi|30794230|ref|NP_569110.1|",1934,0,"tumor necrosis factor receptor superfamily member 1B precursor [Rattus norvegicus]","gi|32453424|gb|AY191269.1|",5063,0,"Rattus norvegicus TNFR2 transcript variant 3 mRNA, complete cds","Q80WY6",749,0,"Tumor necrosis factor receptor superfamily member 1B",".",".",".",".","pfam00020","TNFR_c6","TNFR/NGFR cysteine-rich region.","GO:0002718|regulation of cytokine production involved in immune response;GO:0002724|regulation of T cell cytokine production;GO:0003176|aortic valve development;GO:0003177|pulmonary valve development;GO:0003332|negative regulation of extracellular matrix constituent secretion;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007166|cell surface receptor signaling pathway;GO:0007568|aging;GO:0008630|intrinsic apoptotic signaling pathway in response to DNA damage;GO:0010614|negative regulation of cardiac muscle hypertrophy;GO:0031641|regulation of myelination;GO:0031643|positive regulation of myelination;GO:0032496|response to lipopolysaccharide;GO:0033209|tumor necrosis factor-mediated signaling pathway;GO:0042129|regulation of T cell proliferation;GO:0048714|positive regulation of oligodendrocyte differentiation;GO:0050728|negative regulation of inflammatory response;GO:0050779|RNA destabilization;GO:0051044|positive regulation of membrane protein ectodomain proteolysis;GO:0060548|negative regulation of cell death;GO:0071222|cellular response to lipopolysaccharide;GO:0071356|cellular response to tumor necrosis factor;GO:0071363|cellular response to growth factor stimulus;GO:0097191|extrinsic apoptotic signaling pathway;GO:0150077|regulation of neuroinflammatory response;GO:0150079|negative regulation of neuroinflammatory response;GO:1901215|negative regulation of neuron death;GO:1902339|positive regulation of apoptotic process involved in morphogenesis;GO:2001141|regulation of RNA biosynthetic process;","GO:0005634|nucleus;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0043025|neuronal cell body;GO:0043196|varicosity;GO:0045121|membrane raft;GO:0048471|perinuclear region of cytoplasm;","GO:0005031|tumor necrosis factor-activated receptor activity;GO:0031625|ubiquitin protein ligase binding;GO:0043120|tumor necrosis factor binding;","K05141","TNFRSF1B, TNFR2, CD120b; tumor necrosis factor receptor superfamily member 1B"]
["ENSRNOG00000022764",211,17.51862537,13,0.836295696,20.94788416,4.388732627,{"v":4.52266e-55,"d":"4.52E-55"},{"v":4.20325e-54,"d":"4.20E-54"},"up","yes","Evi2a","protein_coding","chr10:64485200-64489843:-","gi|112983874|ref|NP_001037752.1|",1170,{"v":1E-150,"d":"1.00E-150"},"protein EVI2A precursor [Rattus norvegicus]","gi|281371508|gb|AC123294.3|",2519,0,"Rattus norvegicus BAC CH230-333F9 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P20934",379,{"v":6e-123,"d":"6.00E-123"},"Protein EVI2A",".",".",".",".","pfam05399","EVI2A","Ectropic viral integration site 2A protein (EVI2A). This family contains several mammalian ectropic viral integration site 2A (EVI2A) proteins. The function of this protein is unknown although it is thought to be a membrane protein and may function as an oncogene in retrovirus induced myeloid tumors.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000003305",203,16.85441209,10,0.643304382,26.19974706,4.711480978,{"v":1.29045E-54,"d":"1.29E-54"},{"v":1.19411E-53,"d":"1.19E-53"},"up","yes","Cxcr3","protein_coding","chrX:66844318-66846969:-","gi|16758152|ref|NP_445867.1|",1397,0,"C-X-C chemokine receptor type 3 [Rattus norvegicus]","gi|16758151|ref|NM_053415.1|",1504,0,"Rattus norvegicus chemokine (C-X-C motif) receptor 3 (Cxcr3), mRNA","Q9JII9",542,0,"C-X-C chemokine receptor type 3",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001525|angiogenesis;GO:0001937|negative regulation of endothelial cell proliferation;GO:0002685|regulation of leukocyte migration;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007166|cell surface receptor signaling pathway;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0008284|positive regulation of cell proliferation;GO:0010818|T cell chemotaxis;GO:0016525|negative regulation of angiogenesis;GO:0019722|calcium-mediated signaling;GO:0030155|regulation of cell adhesion;GO:0045766|positive regulation of angiogenesis;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050921|positive regulation of chemotaxis;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;GO:0060326|cell chemotaxis;GO:0070098|chemokine-mediated signaling pathway;GO:1900118|negative regulation of execution phase of apoptosis;GO:1900119|positive regulation of execution phase of apoptosis;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0016493|C-C chemokine receptor activity;GO:0016494|C-X-C chemokine receptor activity;GO:0019956|chemokine binding;GO:0019957|C-C chemokine binding;GO:0019958|C-X-C chemokine binding;GO:0038023|signaling receptor activity;","K04188","CXCR3, GPR9, CD183; C-X-C chemokine receptor type 3"]
["ENSRNOG00000016945",463,38.44134382,158,10.16420923,3.782029958,1.919160791,{"v":2.08336e-54,"d":"2.08E-54"},{"v":1.92225e-53,"d":"1.92E-53"},"up","yes","Pla2g2a","protein_coding","chr5:151076442-151079014:+","gi|291621686|ref|NP_113786.3|",770,{"v":2E-100,"d":"2.00E-100"},"phospholipase A2, membrane associated precursor [Rattus norvegicus]","gi|672054379|ref|XM_006239146.2|",859,0,"PREDICTED: Rattus norvegicus phospholipase A2, group IIA (platelets, synovial fluid) (Pla2g2a), transcript variant X1, mRNA","P14423",301,{"v":8e-102,"d":"8.00E-102"},"Phospholipase A2, membrane associated",".",".",".",".","pfam00068","Phospholip_A2_1","Phospholipase A2. Phospholipase A2 releases fatty acids from the second carbon group of glycerol. Perhaps the best known members are secreted snake venoms, but also found in secreted pancreatic and membrane-associated forms. Structure is all-alpha, with two core disulfide-linked helices and a calcium-binding loop. This alignment represents the major family of PLA2s. A second minor family, defined by the honeybee venom PLA2 PDB:1POC and related sequences from Gila monsters (Heloderma), is not recognized. This minor family conserves the core helix pair but is substantially different elsewhere. The PROSITE pattern PA2_HIS, specific to the first core helix, recognizes both families.","GO:0006644|phospholipid metabolic process;GO:0006954|inflammatory response;GO:0016042|lipid catabolic process;GO:0019835|cytolysis;GO:0036335|intestinal stem cell homeostasis;GO:0046337|phosphatidylethanolamine metabolic process;GO:0046470|phosphatidylcholine metabolic process;GO:0046473|phosphatidic acid metabolic process;GO:0050482|arachidonic acid secretion;GO:0050830|defense response to Gram-positive bacterium;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:1902563|regulation of neutrophil activation;","GO:0005615|extracellular space;GO:0005741|mitochondrial outer membrane;GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0030141|secretory granule;GO:0048471|perinuclear region of cytoplasm;","GO:0004623|phospholipase A2 activity;GO:0005509|calcium ion binding;GO:0005543|phospholipid binding;GO:0047498|calcium-dependent phospholipase A2 activity;","K01047","PLA2G, SPLA2; secretory phospholipase A2 [EC:3.1.1.4]"]
["ENSRNOG00000033444",280,23.24746495,47,3.023530595,7.688847266,2.942767321,{"v":2.91577e-54,"d":"2.92E-54"},{"v":2.68642e-53,"d":"2.69E-53"},"up","yes","F10","protein_coding","chr16:76468838-76488141:-","gi|149057627|gb|EDM08870.1|",2594,0,"coagulation factor X [Rattus norvegicus]","gi|56961646|ref|NM_017143.2|",1566,0,"Rattus norvegicus coagulation factor X (F10), mRNA","Q63207",978,0,"Coagulation factor X","VC1649",118,{"v":1E-27,"d":"1.00E-27"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;GO:0007596|blood coagulation;GO:0051897|positive regulation of protein kinase B signaling;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005783|endoplasmic reticulum;GO:0016020|membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0003674|molecular_function;GO:0004252|serine-type endopeptidase activity;GO:0005509|calcium ion binding;GO:0005543|phospholipid binding;","K01314","F10; coagulation factor X [EC:3.4.21.6]"]
["ENSRNOG00000067705",763,63.34934198,386,24.83154914,2.551163507,1.351155366,{"v":4.02395e-54,"d":"4.02E-54"},{"v":3.69678e-53,"d":"3.70E-53"},"up","yes","Klf2","protein_coding","chr16:17514552-17523944:-","gi|56090542|ref|NP_001007685.1|",1095,{"v":1e-130,"d":"1.00E-130"},"Krueppel-like factor 2 [Rattus norvegicus]","gi|170784839|ref|NM_008452.2|",1104,0,"Mus musculus Kruppel-like factor 2 (lung) (Klf2), mRNA","Q9ET58",426,{"v":3E-132,"d":"3.00E-132"},"Krueppel-like factor 2",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.",".",".",".",".","."]
["ENSRNOG00000010665",245,20.34153183,30,1.929913146,10.54012813,3.3978205,{"v":4.54161e-54,"d":"4.54E-54"},{"v":4.16636e-53,"d":"4.17E-53"},"up","yes","Ccr7","protein_coding","chr10:84097381-84108309:-","gi|41054914|ref|NP_955783.1|",1823,0,"C-C chemokine receptor type 7 precursor [Rattus norvegicus]","gi|58477680|gb|BC089762.1|",1936,0,"Rattus norvegicus chemokine (C-C motif) receptor 7, mRNA (cDNA clone MGC:108519 IMAGE:7381637), complete cds","P47774",674,0,"C-C chemokine receptor type 7",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0002408|myeloid dendritic cell chemotaxis;GO:0002606|positive regulation of dendritic cell antigen processing and presentation;GO:0002885|positive regulation of hypersensitivity;GO:0002922|positive regulation of humoral immune response;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0019722|calcium-mediated signaling;GO:0032496|response to lipopolysaccharide;GO:0032649|regulation of interferon-gamma production;GO:0032651|regulation of interleukin-1 beta production;GO:0032695|negative regulation of interleukin-12 production;GO:0032735|positive regulation of interleukin-12 production;GO:0038115|chemokine (C-C motif) ligand 19 signaling pathway;GO:0038116|chemokine (C-C motif) ligand 21 signaling pathway;GO:0045060|negative thymic T cell selection;GO:0048872|homeostasis of number of cells;GO:0050862|positive regulation of T cell receptor signaling pathway;GO:0060326|cell chemotaxis;GO:0071345|cellular response to cytokine stimulus;GO:0090023|positive regulation of neutrophil chemotaxis;GO:0097029|mature conventional dendritic cell differentiation;GO:2000510|positive regulation of dendritic cell chemotaxis;GO:2000522|positive regulation of immunological synapse formation;GO:2000525|positive regulation of T cell costimulation;GO:2000526|positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation;","GO:0005739|mitochondrion;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0016493|C-C chemokine receptor activity;GO:0019957|C-C chemokine binding;GO:0035757|chemokine (C-C motif) ligand 19 binding;GO:0035758|chemokine (C-C motif) ligand 21 binding;GO:0038117|C-C motif chemokine 19 receptor activity;GO:0038121|C-C motif chemokine 21 receptor activity;","K04182","CCR7, CD197; C-C chemokine receptor type 7"]
["ENSRNOG00000038740",263,21.83601172,39,2.508887089,8.703465298,3.121589927,{"v":6.47582e-54,"d":"6.48E-54"},{"v":5.93224e-53,"d":"5.93E-53"},"up","yes","Gimap7","protein_coding","chr4:77670367-77675272:+","gi|66730266|ref|NP_001019499.1|",1523,0,"GTPase, IMAP family member 7 [Rattus norvegicus]","gi|60551436|gb|BC091210.1|",1192,0,"Rattus norvegicus GTPase, IMAP family member 7, mRNA (cDNA clone MGC:108919 IMAGE:7381387), complete cds","Q8NHV1",327,{"v":6e-104,"d":"6.00E-104"},"GTPase IMAP family member 7",".",".",".",".","pfam04548","AIG1","AIG1 family. Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.","GO:0046039|GTP metabolic process;","GO:0005794|Golgi apparatus;GO:0005811|lipid droplet;GO:0005829|cytosol;GO:0043231|intracellular membrane-bounded organelle;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;",".","."]
["ENSRNOG00000036711",280,23.24746495,48,3.087861033,7.528662948,2.912393672,{"v":9.96215e-54,"d":"9.96E-54"},{"v":9.11287E-53,"d":"9.11E-53"},"up","yes","Spn","protein_coding","chr1:181746429-181759628:-","gi|402747140|ref|NP_001258015.1|",1433,{"v":2E-180,"d":"2.00E-180"},"leukosialin precursor [Rattus norvegicus]","gi|672038365|ref|XM_008759858.1|",4281,0,"PREDICTED: Rattus norvegicus sialophorin (Spn), transcript variant X2, mRNA","P13838",541,{"v":1E-176,"d":"1.00E-176"},"Leukosialin (Fragment)",".",".",".",".","pfam05109","Herpes_BLLF1","Herpes virus major outer envelope glycoprotein (BLLF1). This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralizing antibodies in vivo.","GO:0001562|response to protozoan;GO:0001808|negative regulation of type IV hypersensitivity;GO:0001934|positive regulation of protein phosphorylation;GO:0002296|T-helper 1 cell lineage commitment;GO:0002544|chronic inflammatory response;GO:0007162|negative regulation of cell adhesion;GO:0007166|cell surface receptor signaling pathway;GO:0010468|regulation of gene expression;GO:0031295|T cell costimulation;GO:0032760|positive regulation of tumor necrosis factor production;GO:0042102|positive regulation of T cell proliferation;GO:0042117|monocyte activation;GO:0042130|negative regulation of T cell proliferation;GO:0042742|defense response to bacterium;GO:0045060|negative thymic T cell selection;GO:0050688|regulation of defense response to virus;GO:0050776|regulation of immune response;GO:0050852|T cell receptor signaling pathway;GO:0050863|regulation of T cell activation;GO:0050868|negative regulation of T cell activation;GO:0050901|leukocyte tethering or rolling;GO:0071594|thymocyte aggregation;GO:0097190|apoptotic signaling pathway;GO:2000404|regulation of T cell migration;GO:2000406|positive regulation of T cell migration;","GO:0001931|uropod;GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0005887|integral component of plasma membrane;GO:0005902|microvillus;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016605|PML body;GO:0032154|cleavage furrow;","GO:0004888|transmembrane signaling receptor activity;GO:0005515|protein binding;GO:0019904|protein domain specific binding;GO:0030544|Hsp70 protein binding;GO:0031072|heat shock protein binding;","K06477","SPN, CD43; sialophorin"]
["ENSRNOG00000050205",1025,85.10232704,613,39.43455861,2.158064653,1.109738087,{"v":2.36085E-53,"d":"2.36E-53"},{"v":2.1473E-52,"d":"2.15E-52"},"up","yes","Afmid","protein_coding","chr10:103046180-103061718:+","gi|162462839|ref|NP_001104836.1|",1441,0,"kynurenine formamidase [Rattus norvegicus]","gi|162462838|ref|NM_001111366.1|",2508,0,"Rattus norvegicus arylformamidase (Afmid), mRNA","Q8K4H1",473,{"v":3e-159,"d":"3.00E-159"},"Kynurenine formamidase","mll5717",101,{"v":3e-22,"d":"3.00E-22"},"COG0657","pfam10983","DUF2793","Protein of unknown function (DUF2793). This is a bacterial family of proteins with unknown function.","GO:0019441|tryptophan catabolic process to kynurenine;GO:0034354|'de novo' NAD biosynthetic process from tryptophan;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004061|arylformamidase activity;GO:0016787|hydrolase activity;","K01432","AFMID; arylformamidase [EC:3.5.1.9]"]
["ENSRNOG00000048088",1130,93.82012639,707,45.4816198,2.062814095,1.044613809,{"v":2.61163E-53,"d":"2.61E-53"},{"v":2.36866e-52,"d":"2.37E-52"},"up","yes","Mest","protein_coding","chr4:59354447-59366145:+","gi|57528148|ref|NP_001009617.1|",1712,0,"mesoderm-specific transcript homolog protein [Rattus norvegicus]","gi|356582505|ref|NM_008590.2|",1821,0,"Mus musculus mesoderm specific transcript (Mest), transcript variant 2, mRNA","Q6P5P5",664,0,"Mesoderm-specific transcript homolog protein",".",".",".",".","pfam12697","Abhydrolase_6","Alpha/beta hydrolase family. This family contains alpha/beta hydrolase enzymes of diverse specificity.","GO:0010883|regulation of lipid storage;GO:0032526|response to retinoic acid;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0016787|hydrolase activity;",".","."]
["ENSRNOG00000062487",589,48.90270305,253,16.27560086,3.004663451,1.587203405,{"v":3.71626E-53,"d":"3.72E-53"},{"v":3.3515e-52,"d":"3.35E-52"},"up","yes","ENSRNOG00000062487","protein_coding","chr20:4870851-4906450:-","gi|829760817|ref|XP_012619031.1|",369,{"v":5e-66,"d":"5.00E-66"},"PREDICTED: LOW QUALITY PROTEIN: saoe class I histocompatibility antigen, A alpha chain-like [Microcebus murinus]","gi|46237532|emb|BX883042.1|",1179,0,"Rattus norvegicus chromosome 20, major histocompatibility complex, assembled from 40 BACs, strain Brown Norway (BN/ssNHsd), RT1n haplotype; segment 1/11","P16391",171,{"v":5e-47,"d":"5.00E-47"},"RT1 class I histocompatibility antigen, AA alpha chain",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.",".",".",".",".","."]
["ENSRNOG00000008369",488,40.51701034,180,11.57947887,3.499035732,1.806957397,{"v":6.6531e-53,"d":"6.65E-53"},{"v":5.99163e-52,"d":"5.99E-52"},"up","yes","Gimap4","protein_coding","chr4:77636401-77643306:+","gi|76677905|ref|NP_775176.2|",1395,0,"GTPase IMAP family member 4 [Rattus norvegicus]","gi|76677904|ref|NM_173153.2|",1442,0,"Rattus norvegicus GTPase, IMAP family member 4 (Gimap4), mRNA","Q8K3K9",538,0,"GTPase IMAP family member 4","RSc1064",49.7,8e-06,"COG1159","pfam04548","AIG1","AIG1 family. Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.",".","GO:0005829|cytosol;","GO:0005525|GTP binding;",".","."]
["ENSRNOG00000031930",385,31.9652643,111,7.140678639,4.476502293,2.162371925,{"v":7.60172e-53,"d":"7.60E-53"},{"v":6.82671e-52,"d":"6.83E-52"},"up","yes","Bin2","protein_coding","chr7:131742002-131786285:-","gi|444515345|gb|ELV10844.1|",2327,0,"Bridging integrator 2 [Tupaia chinensis]","gi|58866017|ref|NM_001012223.1|",1801,0,"Rattus norvegicus bridging integrator 2 (Bin2), mRNA","Q68FR2",597,0,"Bridging integrator 2","VC1649",81.6,{"v":3e-15,"d":"3.00E-15"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006911|phagocytosis, engulfment;GO:0060326|cell chemotaxis;GO:0071800|podosome assembly;GO:0097320|plasma membrane tubulation;","GO:0001891|phagocytic cup;GO:0002102|podosome;GO:0005886|plasma membrane;GO:0005938|cell cortex;GO:0030054|cell junction;GO:0042995|cell projection;","GO:0005543|phospholipid binding;","K20119","BIN2; bridging integrator 2"]
["ENSRNOG00000002418",893,74.14280785,501,32.22954953,2.300460569,1.201922728,{"v":7.89586E-53,"d":"7.90E-53"},{"v":7.08092e-52,"d":"7.08E-52"},"up","yes","Tgfb2","protein_coding","chr13:98160087-98261405:-","gi|149040974|gb|EDL94931.1|",2044,0,"transforming growth factor, beta 2, isoform CRA_a [Rattus norvegicus]","gi|672075217|ref|XM_006250448.2|",3531,0,"PREDICTED: Rattus norvegicus transforming growth factor, beta 2 (Tgfb2), transcript variant X1, mRNA","Q07257",789,0,"Transforming growth factor beta-2",".",".",".",".","pfam00019","TGF_beta","Transforming growth factor beta like domain.","GO:0000902|cell morphogenesis;GO:0001501|skeletal system development;GO:0001502|cartilage condensation;GO:0001558|regulation of cell growth;GO:0001568|blood vessel development;GO:0001654|eye development;GO:0001666|response to hypoxia;GO:0001822|kidney development;GO:0001837|epithelial to mesenchymal transition;GO:0001843|neural tube closure;GO:0001942|hair follicle development;GO:0001974|blood vessel remodeling;GO:0003007|heart morphogenesis;GO:0003148|outflow tract septum morphogenesis;GO:0003149|membranous septum morphogenesis;GO:0003179|heart valve morphogenesis;GO:0003181|atrioventricular valve morphogenesis;GO:0003184|pulmonary valve morphogenesis;GO:0003203|endocardial cushion morphogenesis;GO:0003215|cardiac right ventricle morphogenesis;GO:0003222|ventricular trabecula myocardium morphogenesis;GO:0003274|endocardial cushion fusion;GO:0003289|atrial septum primum morphogenesis;GO:0003407|neural retina development;GO:0006468|protein phosphorylation;GO:0007165|signal transduction;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0007411|axon guidance;GO:0007435|salivary gland morphogenesis;GO:0007507|heart development;GO:0007519|skeletal muscle tissue development;GO:0007565|female pregnancy;GO:0007568|aging;GO:0008219|cell death;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0008347|glial cell migration;GO:0008584|male gonad development;GO:0009314|response to radiation;GO:0009409|response to cold;GO:0009410|response to xenobiotic stimulus;GO:0009611|response to wounding;GO:0010002|cardioblast differentiation;GO:0010243|response to organonitrogen compound;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010634|positive regulation of epithelial cell migration;GO:0010693|negative regulation of alkaline phosphatase activity;GO:0010718|positive regulation of epithelial to mesenchymal transition;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0010936|negative regulation of macrophage cytokine production;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0016477|cell migration;GO:0016525|negative regulation of angiogenesis;GO:0030097|hemopoiesis;GO:0030198|extracellular matrix organization;GO:0030199|collagen fibril organization;GO:0030307|positive regulation of cell growth;GO:0030308|negative regulation of cell growth;GO:0030324|lung development;GO:0030326|embryonic limb morphogenesis;GO:0030335|positive regulation of cell migration;GO:0030509|BMP signaling pathway;GO:0030593|neutrophil chemotaxis;GO:0030878|thyroid gland development;GO:0030902|hindbrain development;GO:0031016|pancreas development;GO:0031069|hair follicle morphogenesis;GO:0032147|activation of protein kinase activity;GO:0032355|response to estradiol;GO:0032526|response to retinoic acid;GO:0032570|response to progesterone;GO:0032874|positive regulation of stress-activated MAPK cascade;GO:0032909|regulation of transforming growth factor beta2 production;GO:0032956|regulation of actin cytoskeleton organization;GO:0033280|response to vitamin D;GO:0033630|positive regulation of cell adhesion mediated by integrin;GO:0034097|response to cytokine;GO:0034616|response to laminar fluid shear stress;GO:0035910|ascending aorta morphogenesis;GO:0042060|wound healing;GO:0042127|regulation of cell proliferation;GO:0042416|dopamine biosynthetic process;GO:0042981|regulation of apoptotic process;GO:0043065|positive regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0043525|positive regulation of neuron apoptotic process;GO:0043627|response to estrogen;GO:0045216|cell-cell junction organization;GO:0045726|positive regulation of integrin biosynthetic process;GO:0045747|positive regulation of Notch signaling pathway;GO:0045778|positive regulation of ossification;GO:0045787|positive regulation of cell cycle;GO:0045823|positive regulation of heart contraction;GO:0046580|negative regulation of Ras protein signal transduction;GO:0048103|somatic stem cell division;GO:0048565|digestive tract development;GO:0048566|embryonic digestive tract development;GO:0048663|neuron fate commitment;GO:0048666|neuron development;GO:0048702|embryonic neurocranium morphogenesis;GO:0048839|inner ear development;GO:0050680|negative regulation of epithelial cell proliferation;GO:0050714|positive regulation of protein secretion;GO:0050777|negative regulation of immune response;GO:0050778|positive regulation of immune response;GO:0051280|negative regulation of release of sequestered calcium ion into cytosol;GO:0051726|regulation of cell cycle;GO:0051781|positive regulation of cell division;GO:0051794|regulation of timing of catagen;GO:0051795|positive regulation of timing of catagen;GO:0051891|positive regulation of cardioblast differentiation;GO:0060038|cardiac muscle cell proliferation;GO:0060065|uterus development;GO:0060317|cardiac epithelial to mesenchymal transition;GO:0060325|face morphogenesis;GO:0060364|frontal suture morphogenesis;GO:0060389|pathway-restricted SMAD protein phosphorylation;GO:0060395|SMAD protein signal transduction;GO:0060412|ventricular septum morphogenesis;GO:0060413|atrial septum morphogenesis;GO:0061037|negative regulation of cartilage development;GO:0061626|pharyngeal arch artery morphogenesis;GO:0062009|secondary palate development;GO:0070237|positive regulation of activation-induced cell death of T cells;GO:0090091|positive regulation of extracellular matrix disassembly;GO:0097191|extrinsic apoptotic signaling pathway;GO:1900182|positive regulation of protein localization to nucleus;GO:1902256|regulation of apoptotic process involved in outflow tract morphogenesis;GO:1902895|positive regulation of pri-miRNA transcription by RNA polymerase II;GO:1903053|regulation of extracellular matrix organization;GO:1903701|substantia propria of cornea development;GO:1904238|pericyte cell differentiation;GO:1904426|positive regulation of GTP binding;GO:1904888|cranial skeletal system development;GO:1905006|negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation;GO:1905007|positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation;GO:2001241|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand;","GO:0005576|extracellular region;GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005802|trans-Golgi network;GO:0009986|cell surface;GO:0030141|secretory granule;GO:0030424|axon;GO:0031012|extracellular matrix;GO:0043025|neuronal cell body;GO:0062023|collagen-containing extracellular matrix;","GO:0001540|amyloid-beta binding;GO:0005102|signaling receptor binding;GO:0005114|type II transforming growth factor beta receptor binding;GO:0005125|cytokine activity;GO:0005160|transforming growth factor beta receptor binding;GO:0008083|growth factor activity;GO:0034714|type III transforming growth factor beta receptor binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0044877|protein-containing complex binding;GO:0047485|protein N-terminus binding;","K13376","TGFB2; transforming growth factor beta-2"]
["ENSRNOG00000013862",205,17.02046541,15,0.964956573,17.63858176,4.14066266,{"v":5.24497e-52,"d":"5.24E-52"},{"v":4.64499e-51,"d":"4.64E-51"},"up","yes","Dusp2","protein_coding","chr3:114556325-114558499:+","gi|58865748|ref|NP_001012089.1|",1420,0,"dual specificity protein phosphatase 2 [Rattus norvegicus]","gi|58865747|ref|NM_001012089.1|",1623,0,"Rattus norvegicus dual specificity phosphatase 2 (Dusp2), mRNA","Q05922",536,0,"Dual specificity protein phosphatase 2","SPBC17A3.06",74.3,{"v":1E-13,"d":"1.00E-13"},"COG2453","pfam00782","DSPc","Dual specificity phosphatase, catalytic domain. Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a \"recognition\" region.","GO:0001706|endoderm formation;GO:0006470|protein dephosphorylation;GO:0043409|negative regulation of MAPK cascade;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0031965|nuclear membrane;","GO:0004721|phosphoprotein phosphatase activity;GO:0004725|protein tyrosine phosphatase activity;GO:0008330|protein tyrosine/threonine phosphatase activity;GO:0017017|MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0051019|mitogen-activated protein kinase binding;","K04459","DUSP, MKP; dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48]"]
["ENSRNOG00000053272",207,17.18651873,16,1.029287011,16.6974989,4.061560114,{"v":6.20409e-52,"d":"6.20E-52"},{"v":5.47922e-51,"d":"5.48E-51"},"up","yes","Chi3l1","protein_coding","chr13:45641802-45649787:+","gi|832626572|ref|NP_001296749.1|",2116,0,"chitinase-3-like protein 1 isoform 1 precursor [Rattus norvegicus]","gi|832626571|ref|NM_001309820.1|",1678,0,"Rattus norvegicus chitinase 3 like 1 (Chi3l1), transcript variant 1, mRNA","Q9WTV1",789,0,"Chitinase-3-like protein 1","BH0916_1",165,{"v":8e-44,"d":"8.00E-44"},"COG3325","pfam00704","Glyco_hydro_18","Glycosyl hydrolases family 18.","GO:0005975|carbohydrate metabolic process;GO:0006032|chitin catabolic process;GO:0006915|apoptotic process;GO:0006954|inflammatory response;GO:0007250|activation of NF-kappaB-inducing kinase activity;GO:0009612|response to mechanical stimulus;GO:0010800|positive regulation of peptidyl-threonine phosphorylation;GO:0030324|lung development;GO:0032757|positive regulation of interleukin-8 production;GO:0034612|response to tumor necrosis factor;GO:0045766|positive regulation of angiogenesis;GO:0051897|positive regulation of protein kinase B signaling;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070555|response to interleukin-1;GO:0070741|response to interleukin-6;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0048471|perinuclear region of cytoplasm;","GO:0003674|molecular_function;GO:0008061|chitin binding;GO:0030246|carbohydrate binding;","K17523","CHI3L1_2; chitinase-3-like protein 1/2"]
["ENSRNOG00000033747",1175,97.55632612,758,48.76247214,2.000643565,1.000464159,{"v":1.09613E-51,"d":"1.10E-51"},{"v":9.60103e-51,"d":"9.60E-51"},"up","yes","Sp110","protein_coding","chr9:86200503-86222670:-","gi|77628031|ref|NP_001029309.1|",2417,0,"sp110 nuclear body protein [Rattus norvegicus]","gi|77628030|ref|NM_001034137.1|",1762,0,"Rattus norvegicus SP110 nuclear body protein (Sp110), mRNA","Q3KRF1",935,0,"Sp110 nuclear body protein",".",".",".",".","pfam03172","Sp100","Sp100 domain. The function of this domain is unknown. It is about 105 amino acid residues in length and is predicted to be predominantly alpha helical. This domain is usually found at the amino terminus of protein that contain a SAND domain pfam01342.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0006915|apoptotic process;GO:0009617|response to bacterium;GO:0043065|positive regulation of apoptotic process;GO:0045087|innate immune response;","GO:0005634|nucleus;GO:0005654|nucleoplasm;","GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677|DNA binding;","K24503","SP110; nuclear body protein Sp110"]
["ENSRNOG00000030467",334,27.73090462,83,5.339426369,5.193611204,2.376738017,{"v":1.81303e-51,"d":"1.81E-51"},{"v":1.57509e-50,"d":"1.58E-50"},"up","yes","Ube2l6","protein_coding","chr3:69873424-69888048:+","gi|67078502|ref|NP_001019926.1|",767,{"v":3e-99,"d":"3.00E-99"},"ubiquitin/ISG15-conjugating enzyme E2 L6 [Rattus norvegicus]","gi|67078501|ref|NM_001024755.1|",928,0,"Rattus norvegicus ubiquitin-conjugating enzyme E2L 6 (Ube2l6), mRNA","Q4V8J2",300,{"v":9e-101,"d":"9.00E-101"},"Ubiquitin/ISG15-conjugating enzyme E2 L6","YDR059c",89.4,{"v":1e-20,"d":"1.00E-20"},"COG5078","pfam00179","UQ_con","Ubiquitin-conjugating enzyme. Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. TSG101 is one of several UBC homologues that lacks this active site cysteine.","GO:0000209|protein polyubiquitination;GO:0006511|ubiquitin-dependent protein catabolic process;GO:0019941|modification-dependent protein catabolic process;GO:0032020|ISG15-protein conjugation;","GO:0000151|ubiquitin ligase complex;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0019787|ubiquitin-like protein transferase activity;GO:0031625|ubiquitin protein ligase binding;GO:0042296|ISG15 transferase activity;GO:0043130|ubiquitin binding;GO:0061631|ubiquitin conjugating enzyme activity;","K04553","UBE2L6, UBCH8; ubiquitin-conjugating enzyme E2 L6 [EC:2.3.2.23]"]
["ENSRNOG00000058545",456,37.8601572,163,10.48586142,3.61059103,1.852235016,{"v":3.40831e-51,"d":"3.41E-51"},{"v":2.93312e-50,"d":"2.93E-50"},"up","yes","ENSRNOG00000058545","protein_coding","chrX:151632454-151651128:-","gi|78486570|ref|NP_653341.2|",4443,0,"rho GTPase-activating protein 4 [Rattus norvegicus]","gi|53830690|gb|AY742900.1|",6946,0,"Rattus norvegicus Rho GTPase activating protein 4 (Arhgap4) mRNA, complete cds","P98171",1361,0,"Rho GTPase-activating protein 4",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007165|signal transduction;GO:0007399|nervous system development;GO:0010764|negative regulation of fibroblast migration;GO:0030336|negative regulation of cell migration;GO:0030517|negative regulation of axon extension;GO:0035023|regulation of Rho protein signal transduction;GO:0050790|regulation of catalytic activity;","GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005874|microtubule;GO:0030426|growth cone;","GO:0005096|GTPase activator activity;GO:0042802|identical protein binding;","K20122","ARHGAP4; Rho GTPase-activating protein 4"]
["ENSRNOG00000000902",1109,92.07656652,701,45.09563717,2.041806532,1.029846172,{"v":3.48009e-51,"d":"3.48E-51"},{"v":2.99086E-50,"d":"2.99E-50"},"up","yes","Hsph1","protein_coding","chr12:5390922-5410224:+","gi|58865372|ref|NP_001011901.1|",4298,0,"heat shock protein 105 kDa [Rattus norvegicus]","gi|58865371|ref|NM_001011901.1|",3120,0,"Rattus norvegicus heat shock 105/110 protein 1 (Hsph1), mRNA","Q66HA8",1660,0,"Heat shock protein 105 kDa","YBR169c",392,{"v":4e-118,"d":"4.00E-118"},"COG0443","pfam00012","HSP70","Hsp70 protein. Hsp70 chaperones help to fold many proteins. Hsp70 assisted folding involves repeated cycles of substrate binding and release. Hsp70 activity is ATP dependent. Hsp70 proteins are made up of two regions: the amino terminus is the ATPase domain and the carboxyl terminus is the substrate binding region.","GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050790|regulation of catalytic activity;GO:0051085|chaperone cofactor-dependent protein refolding;GO:0061098|positive regulation of protein tyrosine kinase activity;GO:1903748|negative regulation of establishment of protein localization to mitochondrion;GO:1903751|negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide;GO:1903753|negative regulation of p38MAPK cascade;GO:2001234|negative regulation of apoptotic signaling pathway;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005874|microtubule;GO:0032991|protein-containing complex;","GO:0000774|adenyl-nucleotide exchange factor activity;GO:0005524|ATP binding;GO:0043014|alpha-tubulin binding;","K09485","HSP110; heat shock protein 110kDa"]
["ENSRNOG00000047349",189,15.69203884,9,0.578973944,27.10318661,4.760390579,{"v":3.72411E-51,"d":"3.72E-51"},{"v":3.19629E-50,"d":"3.20E-50"},"up","yes","Ms4a6b","protein_coding","chr1:208291950-208301843:+","gi|293344625|ref|XP_001075462.2|",1117,{"v":4e-151,"d":"4.00E-151"},"PREDICTED: membrane-spanning 4-domains subfamily A member 6B [Rattus norvegicus]","gi|672014687|ref|XM_008774778.1|",915,0,"PREDICTED: Rattus norvegicus membrane-spanning 4-domains, subfamily A, member 6B (Ms4a6b), transcript variant X3, mRNA","Q99N09",323,{"v":8e-109,"d":"8.00E-109"},"Membrane-spanning 4-domains subfamily A member 6B",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.",".",".",".",".","."]
["ENSRNOG00000007679",548,45.49860997,230,14.79600078,3.075061338,1.620615188,{"v":4.85377E-51,"d":"4.85E-51"},{"v":4.14913e-50,"d":"4.15E-50"},"up","yes","Cyth4","protein_coding","chr7:110152272-110176741:+","gi|564361059|ref|XP_006242093.1|",2110,0,"PREDICTED: cytohesin-4 isoform X1 [Rattus norvegicus]","gi|672060229|ref|XM_006242031.2|",2681,0,"PREDICTED: Rattus norvegicus cytohesin 4 (Cyth4), transcript variant X1, mRNA","Q80YW0",791,0,"Cytohesin-4","SPAC30.01c",167,{"v":2E-41,"d":"2.00E-41"},"COG5307","pfam01369","Sec7","Sec7 domain. The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.","GO:0032012|regulation of ARF protein signal transduction;GO:0050790|regulation of catalytic activity;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0034451|centriolar satellite;GO:0045171|intercellular bridge;","GO:0005085|guanyl-nucleotide exchange factor activity;","K18441","CYTH; cytohesin"]
["ENSRNOG00000042133",188,15.60901218,2,0.128660876,121.3190258,6.922662008,{"v":7.14734e-51,"d":"7.15E-51"},{"v":6.10158e-50,"d":"6.10E-50"},"up","yes","AABR07006275.1","protein_coding","chr1:208218000-208236257:+","gi|672014684|ref|XP_008772999.1|",1034,{"v":2e-138,"d":"2.00E-138"},"PREDICTED: LOW QUALITY PROTEIN: membrane-spanning 4-domains subfamily A member 4D-like [Rattus norvegicus]","gi|672014683|ref|XM_008774777.1|",1012,0,"PREDICTED: Rattus norvegicus similar to membrane-spanning 4-domains, subfamily A, member 4C (LOC690862), mRNA","Q99N05",283,{"v":4e-93,"d":"4.00E-93"},"Membrane-spanning 4-domains subfamily A member 4D",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.",".",".",".",".","."]
["ENSRNOG00000049829",181,15.02782556,6,0.385982629,38.93394267,5.282956543,{"v":2.27436e-50,"d":"2.27E-50"},{"v":1.91854e-49,"d":"1.92E-49"},"up","yes","AABR07060872.1","protein_coding","chr4:102404346-102688488:+","gi|92401|pir||S06084",887,{"v":1e-116,"d":"1.00E-116"},"Ig kappa chain precursor - rat","gi|298890810|emb|FQ230756.1|",742,0,"Rattus norvegicus TL0AEA8YC24 mRNA sequence","P0DOX7",248,{"v":5E-80,"d":"5.00E-80"},"Immunoglobulin kappa light chain",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.",".",".",".",".","."]
["ENSRNOG00000019675",317,26.31945139,76,4.889113302,5.38327704,2.428484673,{"v":3.85958E-50,"d":"3.86E-50"},{"v":3.23441e-49,"d":"3.23E-49"},"up","yes","Pycard","protein_coding","chr1:182601174-182602955:-","gi|149067648|gb|EDM17200.1|",894,{"v":1e-116,"d":"1.00E-116"},"PYD and CARD domain containing [Rattus norvegicus]","gi|298915386|emb|FQ226280.1|",421,0,"Rattus norvegicus TL0AEA2YL13 mRNA sequence","Q9EPB4",273,{"v":8e-89,"d":"8.00E-89"},"Apoptosis-associated speck-like protein containing a CARD",".",".",".",".","pfam02758","PYRIN","PAAD/DAPIN/Pyrin domain. This domain is predicted to contain 6 alpha helices and to have the same fold as the pfam00531 domain. This similarity may mean that this is a protein-protein interaction domain.","GO:0001773|myeloid dendritic cell activation;GO:0002218|activation of innate immune response;GO:0002230|positive regulation of defense response to virus by host;GO:0002277|myeloid dendritic cell activation involved in immune response;GO:0002588|positive regulation of antigen processing and presentation of peptide antigen via MHC class II;GO:0002821|positive regulation of adaptive immune response;GO:0006915|apoptotic process;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006954|inflammatory response;GO:0009617|response to bacterium;GO:0010506|regulation of autophagy;GO:0010803|regulation of tumor necrosis factor-mediated signaling pathway;GO:0030838|positive regulation of actin filament polymerization;GO:0031647|regulation of protein stability;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0032688|negative regulation of interferon-beta production;GO:0032722|positive regulation of chemokine production;GO:0032729|positive regulation of interferon-gamma production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032733|positive regulation of interleukin-10 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0033209|tumor necrosis factor-mediated signaling pathway;GO:0042104|positive regulation of activated T cell proliferation;GO:0042771|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0042981|regulation of apoptotic process;GO:0043065|positive regulation of apoptotic process;GO:0043087|regulation of GTPase activity;GO:0043124|negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043280|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043281|regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0044351|macropinocytosis;GO:0045087|innate immune response;GO:0046330|positive regulation of JNK cascade;GO:0050727|regulation of inflammatory response;GO:0050766|positive regulation of phagocytosis;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:0050870|positive regulation of T cell activation;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051260|protein homooligomerization;GO:0051607|defense response to virus;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071222|cellular response to lipopolysaccharide;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071901|negative regulation of protein serine/threonine kinase activity;GO:0072332|intrinsic apoptotic signaling pathway by p53 class mediator;GO:0090200|positive regulation of release of cytochrome c from mitochondria;GO:0097202|activation of cysteine-type endopeptidase activity;GO:1900016|negative regulation of cytokine production involved in inflammatory response;GO:2000406|positive regulation of T cell migration;GO:2001056|positive regulation of cysteine-type endopeptidase activity;GO:2001238|positive regulation of extrinsic apoptotic signaling pathway;GO:2001242|regulation of intrinsic apoptotic signaling pathway;","GO:0000139|Golgi membrane;GO:0005576|extracellular region;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;GO:0008385|IkappaB kinase complex;GO:0032991|protein-containing complex;GO:0043025|neuronal cell body;GO:0061702|inflammasome complex;GO:0072558|NLRP1 inflammasome complex;GO:0072559|NLRP3 inflammasome complex;GO:0097169|AIM2 inflammasome complex;","GO:0002020|protease binding;GO:0005138|interleukin-6 receptor binding;GO:0005515|protein binding;GO:0005523|tropomyosin binding;GO:0017024|myosin I binding;GO:0019899|enzyme binding;GO:0032090|Pyrin domain binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0044325|ion channel binding;GO:0046983|protein dimerization activity;GO:0070700|BMP receptor binding;GO:0097153|cysteine-type endopeptidase activity involved in apoptotic process;","K12799","PYCARD, ASC; apoptosis-associated speck-like protein containing a CARD"]
["ENSRNOG00000017241",1019,84.60416707,629,40.46384562,2.09085829,1.064095285,{"v":1.13083E-49,"d":"1.13E-49"},{"v":9.41488e-49,"d":"9.41E-49"},"up","yes","Dpcd","protein_coding","chr1:244408785-244426888:+","gi|564333908|ref|XP_006231512.1|",1041,{"v":9e-137,"d":"9.00E-137"},"PREDICTED: protein DPCD isoform X1 [Rattus norvegicus]","gi|672040366|ref|XM_006231450.2|",1185,0,"PREDICTED: Rattus norvegicus deleted in primary ciliary dyskinesia (Dpcd), transcript variant X1, mRNA","Q6AYM4",405,{"v":3e-138,"d":"3.00E-138"},"Protein DPCD",".",".",".",".","pfam14913","DPCD","DPCD protein family. This protein is a found in eukaryotes and a mutation in this protein is thought to cause Primary Ciliary Dyskinesia (PCD). This protein is 203 amino acids in length, 23 kDa in size and its function remains unknown. The gene that encodes this protein is a candidate gene for PCD and is expressed during ciliogenesis. PCD affects the airways and reproductive organs, and probing Northern blots show DPCD expression in humans is highest in the testes. Additionally, there is no indication of major splice variants.","GO:0003351|epithelial cilium movement;GO:0007283|spermatogenesis;GO:0007368|determination of left/right symmetry;GO:0021591|ventricular system development;GO:0021670|lateral ventricle development;GO:0021678|third ventricle development;GO:0030317|flagellated sperm motility;GO:0060972|left/right pattern formation;","GO:0005576|extracellular region;",".","K20800","DPCD; protein DPCD"]
["ENSRNOG00000024689",553,45.91374327,240,15.43930516,2.973821864,1.572318231,{"v":2.31931e-49,"d":"2.32E-49"},{"v":1.91601E-48,"d":"1.92E-48"},"up","yes","Hopx","protein_coding","chr14:31075148-31082909:+","gi|149035176|gb|EDL89880.1|",410,{"v":6e-46,"d":"6.00E-46"},"homeobox only domain, isoform CRA_a [Rattus norvegicus]","gi|298914492|emb|FQ229504.1|",798,0,"Rattus norvegicus TL0ADA47YK21 mRNA sequence","Q78ZR5",102,{"v":3E-32,"d":"3.00E-32"},"Homeodomain-only protein",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001829|trophectodermal cell differentiation;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007507|heart development;GO:0008016|regulation of heart contraction;GO:0016575|histone deacetylation;GO:0043393|regulation of protein binding;GO:0043415|positive regulation of skeletal muscle tissue regeneration;GO:0045596|negative regulation of cell differentiation;GO:0048286|lung alveolus development;GO:0051131|chaperone-mediated protein complex assembly;GO:0051155|positive regulation of striated muscle cell differentiation;","GO:0005634|nucleus;",".","K24897","HOPX; homeodomain-only protein"]
["ENSRNOG00000014653",320,26.56853137,80,5.146435055,5.162511736,2.368073156,{"v":3.5098e-49,"d":"3.51E-49"},{"v":2.88829e-48,"d":"2.89E-48"},"up","yes","Arl11","protein_coding","chr15:35480018-35496596:+","gi|61740633|ref|NP_001013451.1|",810,{"v":2E-100,"d":"2.00E-100"},"ADP-ribosylation factor-like protein 11 [Rattus norvegicus]","gi|672078347|ref|XM_006252135.2|",2046,0,"PREDICTED: Rattus norvegicus ADP-ribosylation factor-like 11 (Arl11), transcript variant X1, mRNA","Q5BK71",316,{"v":6E-102,"d":"6.00E-102"},"ADP-ribosylation factor-like protein 11",".",".",".",".","pfam00025","Arf","ADP-ribosylation factor family. Pfam combines a number of different Prosite families together","GO:0002244|hematopoietic progenitor cell differentiation;GO:0006886|intracellular protein transport;GO:0016192|vesicle-mediated transport;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;","GO:0003924|GTPase activity;GO:0005525|GTP binding;","K07959","ARL11; ADP-ribosylation factor-like protein 11"]
["ENSRNOG00000013415",375,31.1349977,115,7.398000391,4.20856935,2.073329891,{"v":6.10371e-49,"d":"6.10E-49"},{"v":5.00998e-48,"d":"5.01E-48"},"up","yes","Ptpn18","protein_coding","chr9:36672362-36690995:+","gi|61556976|ref|NP_001013129.1|",2183,0,"tyrosine-protein phosphatase non-receptor type 18 [Rattus norvegicus]","gi|1669507|gb|U69673.1|RNU69673",1368,0,"Rattus norvegicus protein tyrosine phosphatase 20 mRNA, complete cds","Q61152",781,0,"Tyrosine-protein phosphatase non-receptor type 18","SPAC19D5.01",140,{"v":1e-33,"d":"1.00E-33"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0001825|blastocyst formation;GO:0035335|peptidyl-tyrosine dephosphorylation;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0004725|protein tyrosine phosphatase activity;GO:0004726|non-membrane spanning protein tyrosine phosphatase activity;","K18024","PTPN12_18_22; tyrosine-protein phosphatase non-receptor type 12/18/22 [EC:3.1.3.48]"]
["ENSRNOG00000049994",674,55.95996919,337,21.67935767,2.581255868,1.368073156,{"v":6.62735e-49,"d":"6.63E-49"},{"v":5.43282e-48,"d":"5.43E-48"},"up","yes","Ifi44l","protein_coding","chr2:240668713-240706359:+","gi|392346098|ref|XP_227820.6|",2197,0,"PREDICTED: LOW QUALITY PROTEIN: interferon-induced protein 44-like isoform X2 [Rattus norvegicus]","gi|672044524|ref|XM_227820.8|",1461,0,"PREDICTED: Rattus norvegicus interferon-induced protein 44-like (Ifi44l), transcript variant X2, mRNA","Q9BDB7",602,0,"Interferon-induced protein 44-like",".",".",".",".","pfam05316","VAR1","Mitochondrial ribosomal protein (VAR1). This family consists of the yeast mitochondrial ribosomal proteins VAR1. Mitochondria possess their own ribosomes responsible for the synthesis of a small number of proteins encoded by the mitochondrial genome. In yeast the two ribosomal RNAs and a single ribosomal protein, VAR1, are products of mitochondrial genes, and the remaining approximately 80 ribosomal proteins are encoded in the nucleus. VAR1 along with 15S rRNA are necessary for the formation of mature 37S subunits.","GO:0006955|immune response;GO:0051607|defense response to virus;","GO:0005737|cytoplasm;","GO:0005525|GTP binding;",".","."]
["ENSRNOG00000012508",831,68.9951549,469,30.17097551,2.286805572,1.19333371,{"v":9.5108e-49,"d":"9.51E-49"},{"v":7.77661e-48,"d":"7.78E-48"},"up","yes","Slc39a8","protein_coding","chr2:224256654-224319129:+","gi|58865482|ref|NP_001011952.1|",2351,0,"zinc transporter ZIP8 precursor [Rattus norvegicus]","gi|58865481|ref|NM_001011952.1|",3071,0,"Rattus norvegicus solute carrier family 39 member 8 (Slc39a8), mRNA","Q5FVQ0",910,0,"Zinc transporter ZIP8","RSc2227",84.3,{"v":1e-16,"d":"1.00E-16"},"COG0428","pfam02535","Zip","ZIP Zinc transporter. The ZIP family consists of zinc transport proteins and many putative metal transporters. The main contribution to this family is from the Arabidopsis thaliana ZIP protein family these proteins are responsible for zinc uptake in the plant. Also found within this family are C. elegans proteins of unknown function which are annotated as being similar to human growth arrest inducible gene product, although this protein in not found within this family.","GO:0006351|transcription, DNA-templated;GO:0006355|regulation of transcription, DNA-templated;GO:0006487|protein N-linked glycosylation;GO:0006525|arginine metabolic process;GO:0006824|cobalt ion transport;GO:0006829|zinc ion transport;GO:0006876|cellular cadmium ion homeostasis;GO:0006882|cellular zinc ion homeostasis;GO:0015698|inorganic anion transport;GO:0015701|bicarbonate transport;GO:0030026|cellular manganese ion homeostasis;GO:0030198|extracellular matrix organization;GO:0042391|regulation of membrane potential;GO:0061757|leukocyte adhesion to arterial endothelial cell;GO:0070574|cadmium ion transmembrane transport;GO:0071421|manganese ion transmembrane transport;GO:0071577|zinc ion transmembrane transport;GO:0071578|zinc ion import across plasma membrane;GO:0097080|plasma membrane selenite transport;GO:0098711|iron ion import across plasma membrane;GO:1990079|cartilage homeostasis;GO:1990540|mitochondrial manganese ion transmembrane transport;","GO:0005765|lysosomal membrane;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0031090|organelle membrane;","GO:0005381|iron ion transmembrane transporter activity;GO:0005384|manganese ion transmembrane transporter activity;GO:0005385|zinc ion transmembrane transporter activity;GO:0015086|cadmium ion transmembrane transporter activity;GO:0015087|cobalt ion transmembrane transporter activity;GO:0015106|bicarbonate transmembrane transporter activity;GO:0015296|anion:cation symporter activity;GO:0097079|selenite:proton symporter activity;","K14714","SLC39A8, ZIP8; solute carrier family 39 (zinc transporter), member 8"]
["ENSRNOG00000043503",995,82.61152722,614,39.49888905,2.091489893,1.064531026,{"v":1.41329e-48,"d":"1.41E-48"},{"v":1.14825E-47,"d":"1.15E-47"},"up","yes","Ehd1","protein_coding","chr1:203579869-203602212:+","gi|169642494|gb|AAI60908.1|",2740,0,"Ehd1 protein [Rattus norvegicus]","gi|209870106|ref|NM_001011939.2|",2283,0,"Rattus norvegicus EH-domain containing 1 (Ehd1), mRNA","Q641Z6",1043,0,"EH domain-containing protein 1",".",".",".",".","pfam00350","Dynamin_N","Dynamin family.","GO:0006886|intracellular protein transport;GO:0006897|endocytosis;GO:0010886|positive regulation of cholesterol storage;GO:0010976|positive regulation of neuron projection development;GO:0016197|endosomal transport;GO:0031175|neuron projection development;GO:0032456|endocytic recycling;GO:0034383|low-density lipoprotein particle clearance;GO:0042632|cholesterol homeostasis;GO:0051260|protein homooligomerization;GO:0060271|cilium assembly;GO:0061512|protein localization to cilium;GO:0072659|protein localization to plasma membrane;GO:1901741|positive regulation of myoblast fusion;GO:1990090|cellular response to nerve growth factor stimulus;GO:2001137|positive regulation of endocytic recycling;","GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005769|early endosome;GO:0005811|lipid droplet;GO:0005886|plasma membrane;GO:0010008|endosome membrane;GO:0020018|ciliary pocket membrane;GO:0030139|endocytic vesicle;GO:0031095|platelet dense tubular network membrane;GO:0031901|early endosome membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0048471|perinuclear region of cytoplasm;GO:0055038|recycling endosome membrane;","GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0005525|GTP binding;GO:0031267|small GTPase binding;GO:0042802|identical protein binding;","K12483","EHD1; EH domain-containing protein 1"]
["ENSRNOG00000060246",176,14.61269225,7,0.450313067,32.45007377,5.020149853,{"v":1.63892E-48,"d":"1.64E-48"},{"v":1.32651e-47,"d":"1.33E-47"},"up","yes","Klrd1","protein_coding","chr4:163045067-163056518:+","gi|6981136|ref|NP_036877.1|",886,{"v":6e-115,"d":"6.00E-115"},"natural killer cells antigen CD94 [Rattus norvegicus]","gi|55926195|ref|NM_012745.2|",1347,0,"Rattus norvegicus killer cell lectin like receptor D1 (Klrd1), mRNA","O35778",345,{"v":2E-116,"d":"2.00E-116"},"Natural killer cells antigen CD94",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0001915|negative regulation of T cell mediated cytotoxicity;GO:0002223|stimulatory C-type lectin receptor signaling pathway;GO:0002228|natural killer cell mediated immunity;GO:0002250|adaptive immune response;GO:0008150|biological_process;GO:0045953|negative regulation of natural killer cell mediated cytotoxicity;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;","GO:0005575|cellular_component;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0043235|receptor complex;","GO:0003674|molecular_function;GO:0023024|MHC class I protein complex binding;GO:0023030|MHC class Ib protein binding, via antigen binding groove;GO:0030246|carbohydrate binding;GO:1990405|protein antigen binding;","K06516","KLRD1, CD94; killer cell lectin-like receptor subfamily D member 1"]
["ENSRNOG00000034190",231,19.17915858,33,2.12290446,9.034395538,3.175428078,{"v":2.73362e-48,"d":"2.73E-48"},{"v":2.19862e-47,"d":"2.20E-47"},"up","yes","Ighm","protein_coding","chr6:132329269-133053426:-","gi|56789191|gb|AAH88240.1|",2159,0,"IgG-2a protein [Rattus norvegicus]","gi|56789190|gb|BC088240.1|",1239,0,"Rattus norvegicus gamma-2a immunoglobulin heavy chain, mRNA (cDNA clone MGC:109023 IMAGE:7365825), complete cds","P20760",633,0,"Ig gamma-2A chain C region",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.","GO:0019731|antibacterial humoral response;GO:0050829|defense response to Gram-negative bacterium;","GO:0016021|integral component of membrane;GO:0071756|pentameric IgM immunoglobulin complex;GO:0071757|hexameric IgM immunoglobulin complex;","GO:0003697|single-stranded DNA binding;GO:0031210|phosphatidylcholine binding;GO:0042834|peptidoglycan binding;",".","."]
["ENSRNOG00000016069",181,15.02782556,10,0.643304382,23.3603656,4.545990948,{"v":3.14786e-48,"d":"3.15E-48"},{"v":2.52861e-47,"d":"2.53E-47"},"up","yes","Cd3e","protein_coding","chr8:45303852-45315022:-","gi|672061635|ref|XP_008764383.1|",818,{"v":2E-99,"d":"2.00E-99"},"PREDICTED: T-cell surface glycoprotein CD3 epsilon chain isoform X1 [Rattus norvegicus]","gi|672061634|ref|XM_008766161.1|",1103,0,"PREDICTED: Rattus norvegicus CD3 molecule, epsilon (Cd3e), transcript variant X1, mRNA","P22646",247,{"v":4e-74,"d":"4.00E-74"},"T-cell surface glycoprotein CD3 epsilon chain",".",".",".",".","pfam02189","ITAM","Immunoreceptor tyrosine-based activation motif.","GO:0001954|positive regulation of cell-matrix adhesion;GO:0002250|adaptive immune response;GO:0002669|positive regulation of T cell anergy;GO:0007166|cell surface receptor signaling pathway;GO:0007584|response to nutrient;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0016358|dendrite development;GO:0021549|cerebellum development;GO:0031295|T cell costimulation;GO:0032729|positive regulation of interferon-gamma production;GO:0032743|positive regulation of interleukin-2 production;GO:0032753|positive regulation of interleukin-4 production;GO:0033077|T cell differentiation in thymus;GO:0033634|positive regulation of cell-cell adhesion mediated by integrin;GO:0042102|positive regulation of T cell proliferation;GO:0045059|positive thymic T cell selection;GO:0045060|negative thymic T cell selection;GO:0045879|negative regulation of smoothened signaling pathway;GO:0046641|positive regulation of alpha-beta T cell proliferation;GO:0046649|lymphocyte activation;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050850|positive regulation of calcium-mediated signaling;GO:0050852|T cell receptor signaling pathway;GO:0050870|positive regulation of T cell activation;GO:0097190|apoptotic signaling pathway;","GO:0001772|immunological synapse;GO:0005575|cellular_component;GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0042101|T cell receptor complex;GO:0042105|alpha-beta T cell receptor complex;GO:0043197|dendritic spine;GO:0044297|cell body;","GO:0003674|molecular_function;GO:0004888|transmembrane signaling receptor activity;GO:0017124|SH3 domain binding;GO:0042802|identical protein binding;GO:0046982|protein heterodimerization activity;","K06451","CD3E; T-cell surface glycoprotein CD3 epsilon chain"]
["ENSRNOG00000009360",1047,86.92891357,666,42.84407183,2.02896013,1.020740516,{"v":9.55118e-48,"d":"9.55E-48"},{"v":7.60538e-47,"d":"7.61E-47"},"up","yes","Sh3bp1","protein_coding","chr7:110457710-110470201:+","gi|285002227|ref|NP_001165452.1|",2903,0,"SH3 domain-binding protein 1 [Rattus norvegicus]","gi|285002226|ref|NM_001171981.1|",2407,0,"Rattus norvegicus SH3-domain binding protein 1 (Sh3bp1), mRNA","D3ZFJ3",1122,0,"SH3 domain-binding protein 1",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0006911|phagocytosis, engulfment;GO:0007015|actin filament organization;GO:0016477|cell migration;GO:0030834|regulation of actin filament depolymerization;GO:0032956|regulation of actin cytoskeleton organization;GO:0034329|cell junction assembly;GO:0035020|regulation of Rac protein signal transduction;GO:0043535|regulation of blood vessel endothelial cell migration;GO:0043547|positive regulation of GTPase activity;GO:0045198|establishment of epithelial cell apical/basal polarity;GO:0046847|filopodium assembly;GO:0051058|negative regulation of small GTPase mediated signal transduction;GO:0071526|semaphorin-plexin signaling pathway;GO:0097178|ruffle assembly;","GO:0001891|phagocytic cup;GO:0005622|intracellular;GO:0005634|nucleus;GO:0005829|cytosol;GO:0005912|adherens junction;GO:0005923|bicellular tight junction;GO:0030027|lamellipodium;GO:0031252|cell leading edge;","GO:0005096|GTPase activator activity;GO:0017124|SH3 domain binding;GO:0030215|semaphorin receptor binding;","K20652","SH3BP1, ARHGAP43; SH3-domain binding protein 1"]
["ENSRNOG00000038722",197,16.35625212,18,1.157947887,14.12520572,3.820199974,{"v":1.08521E-47,"d":"1.09E-47"},{"v":8.61985e-47,"d":"8.62E-47"},"up","yes","Tlr1","protein_coding","chr14:43384932-43397125:+","gi|149035377|gb|EDL90081.1|",4050,0,"rCG56938 [Rattus norvegicus]","gi|451770385|ref|NM_001172120.2|",2565,0,"Rattus norvegicus toll-like receptor 1 (Tlr1), mRNA","Q9EPQ1",1340,0,"Toll-like receptor 1",".",".",".",".","pfam01582","TIR","TIR domain. The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.",".",".",".",".","."]
["ENSRNOG00000003895",467,38.77345047,185,11.90113106,3.257963487,1.703970435,{"v":7.23944e-47,"d":"7.24E-47"},{"v":5.6937e-46,"d":"5.69E-46"},"up","yes","Rgs1","protein_coding","chr13:56018554-56022984:-","gi|564381005|ref|XP_006250036.1|",1116,{"v":3e-149,"d":"3.00E-149"},"PREDICTED: regulator of G-protein signaling 1 isoform X1 [Rattus norvegicus]","gi|672074140|ref|XM_006249974.2|",1350,0,"PREDICTED: Rattus norvegicus regulator of G-protein signaling 1 (Rgs1), transcript variant X1, mRNA","P97844",434,{"v":1E-150,"d":"1.00E-150"},"Regulator of G-protein signaling 1",".",".",".",".","pfam00615","RGS","Regulator of G protein signaling domain. RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.","GO:0007165|signal transduction;GO:0007186|G protein-coupled receptor signaling pathway;GO:0008277|regulation of G protein-coupled receptor signaling pathway;GO:0009617|response to bacterium;GO:0009968|negative regulation of signal transduction;GO:0043547|positive regulation of GTPase activity;GO:0061737|leukotriene signaling pathway;","GO:0005829|cytosol;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;","GO:0001965|G-protein alpha-subunit binding;GO:0005096|GTPase activator activity;","K16449","RGS; regulator of G-protein signaling"]
["ENSRNOG00000056585",950,78.8753275,584,37.5689759,2.099480372,1.070032301,{"v":7.76295e-47,"d":"7.76E-47"},{"v":6.09045e-46,"d":"6.09E-46"},"up","yes","Fscn1","protein_coding","chr12:11597048-11610211:-","gi|149034971|gb|EDL89691.1|",2562,0,"rCG42612, isoform CRA_b [Rattus norvegicus]","gi|201066379|ref|NM_001100806.1|",1588,0,"Rattus norvegicus fascin actin-bundling protein 1 (Fscn1), mRNA","P85845",984,0,"Fascin",".",".",".",".","pfam06268","Fascin","Fascin domain. This family consists of several eukaryotic fascin or singed proteins. The fascins are a structurally unique and evolutionarily conserved group of actin cross-linking proteins. Fascins function in the organisation of two major forms of actin-based structures: dynamic, cortical cell protrusions and cytoplasmic microfilament bundles. The cortical structures, which include filopodia, spikes, lamellipodial ribs, oocyte microvilli and the dendrites of dendritic cells, have roles in cell-matrix adhesion, cell interactions and cell migration, whereas the cytoplasmic actin bundles appear to participate in cell architecture.  Dictyostelium hisactophilin, another actin-binding protein, is a submembranous pH sensor that signals slight changes of the H+ concentration to actin by inducing actin polymerization and binding to microfilaments only at pH values below seven. Members of this family are histidine rich, typically contain the repeated motif of HHXH.",".",".",".",".","."]
["ENSRNOG00000001216",235,19.51126522,38,2.444556651,7.981514855,2.996662589,{"v":1.3056e-46,"d":"1.31E-46"},{"v":1.01931e-45,"d":"1.02E-45"},"up","yes","Trpm2","protein_coding","chr20:10707014-10753181:+","gi|564397367|ref|XP_006256310.1|",7426,0,"PREDICTED: transient receptor potential cation channel subfamily M member 2 isoform X1 [Rattus norvegicus]","gi|672085964|ref|XM_006256248.2|",5387,0,"PREDICTED: Rattus norvegicus transient receptor potential cation channel, subfamily M, member 2 (Trpm2), transcript variant X1, mRNA","E9PTA2",2849,0,"Transient receptor potential cation channel subfamily M member 2",".",".",".",".","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0001659|temperature homeostasis;GO:0002407|dendritic cell chemotaxis;GO:0006828|manganese ion transport;GO:0009408|response to heat;GO:0014074|response to purine-containing compound;GO:0032024|positive regulation of insulin secretion;GO:0033194|response to hydroperoxide;GO:0035584|calcium-mediated signaling using intracellular calcium source;GO:0035725|sodium ion transmembrane transport;GO:0044849|estrous cycle;GO:0051209|release of sequestered calcium ion into cytosol;GO:0051289|protein homotetramerization;GO:0051489|regulation of filopodium assembly;GO:0070301|cellular response to hydrogen peroxide;GO:0070588|calcium ion transmembrane transport;GO:0071277|cellular response to calcium ion;GO:0071415|cellular response to purine-containing compound;GO:0071421|manganese ion transmembrane transport;GO:0071502|cellular response to temperature stimulus;GO:0071577|zinc ion transmembrane transport;GO:0097028|dendritic cell differentiation;GO:0097553|calcium ion transmembrane import into cytosol;GO:0098655|cation transmembrane transport;GO:0098703|calcium ion import across plasma membrane;GO:1903223|positive regulation of oxidative stress-induced neuron death;GO:2000249|regulation of actin cytoskeleton reorganization;","GO:0005764|lysosome;GO:0005765|lysosomal membrane;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0030659|cytoplasmic vesicle membrane;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043204|perikaryon;","GO:0003674|molecular_function;GO:0005261|cation channel activity;GO:0005272|sodium channel activity;GO:0005384|manganese ion transmembrane transporter activity;GO:0005509|calcium ion binding;GO:0015278|calcium-release channel activity;GO:0072571|mono-ADP-D-ribose binding;GO:0099604|ligand-gated calcium channel activity;","K04977","TRPM2; transient receptor potential cation channel subfamily M member 2 [EC:3.6.1.13]"]
["ENSRNOG00000013371",338,28.06301126,98,6.304382942,4.451349405,2.154242748,{"v":2.11714E-46,"d":"2.12E-46"},{"v":1.64287e-45,"d":"1.64E-45"},"up","yes","ENSRNOG00000013371","protein_coding","chr3:142381374-142395308:+","gi|564343773|ref|XP_006235379.1|",2300,0,"PREDICTED: BPI fold-containing family B member 6 isoform X1 [Rattus norvegicus]","gi|564343772|ref|XM_006235317.1|",1520,0,"PREDICTED: Rattus norvegicus BPI fold containing family B, member 6 (Bpifb6), transcript variant X1, mRNA","Q8BU51",810,0,"BPI fold-containing family B member 6",".",".",".",".","pfam01273","LBP_BPI_CETP","LBP / BPI / CETP family, N-terminal domain. The N and C terminal domains of the LBP/BPI/CETP family are structurally similar.",".","GO:0005576|extracellular region;","GO:0008289|lipid binding;",".","."]
["ENSRNOG00000004763",405,33.62579751,143,9.19925266,3.655274918,1.869979917,{"v":3.08176e-46,"d":"3.08E-46"},{"v":2.38743e-45,"d":"2.39E-45"},"up","yes","Sirpa","protein_coding","chr3:116819726-116858098:+","gi|29427383|sp|P97710.1|SHPS1_RAT",2366,0,"RecName: Full=Tyrosine-protein phosphatase non-receptor type substrate 1; Short=SHP substrate 1; Short=SHPS-1; AltName: Full=Brain Ig-like molecule with tyrosine-based activation motifs; Short=Bit; AltName: Full=CD172 antigen-like family member A; AltName: Full=Inhibitory receptor SHPS-1; AltName: Full=Macrophage fusion receptor; AltName: Full=Macrophage membrane protein MFP150; AltName: Full=Signal-regulatory protein alpha-1; Short=Sirp-alpha-1; AltName: CD_antigen=CD172a; Flags: Precursor","gi|672046774|ref|XM_006234951.2|",3825,0,"PREDICTED: Rattus norvegicus signal-regulatory protein alpha (Sirpa), transcript variant X1, mRNA","P97710",915,0,"Tyrosine-protein phosphatase non-receptor type substrate 1",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0001933|negative regulation of protein phosphorylation;GO:0002244|hematopoietic progenitor cell differentiation;GO:0006910|phagocytosis, recognition;GO:0006911|phagocytosis, engulfment;GO:0007010|cytoskeleton organization;GO:0007015|actin filament organization;GO:0007160|cell-matrix adhesion;GO:0010468|regulation of gene expression;GO:0016477|cell migration;GO:0032649|regulation of interferon-gamma production;GO:0032651|regulation of interleukin-1 beta production;GO:0032675|regulation of interleukin-6 production;GO:0032680|regulation of tumor necrosis factor production;GO:0032688|negative regulation of interferon-beta production;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0034113|heterotypic cell-cell adhesion;GO:0035696|monocyte extravasation;GO:0045019|negative regulation of nitric oxide biosynthetic process;GO:0045428|regulation of nitric oxide biosynthetic process;GO:0046329|negative regulation of JNK cascade;GO:0050728|negative regulation of inflammatory response;GO:0050765|negative regulation of phagocytosis;GO:0050766|positive regulation of phagocytosis;GO:0050790|regulation of catalytic activity;GO:0050870|positive regulation of T cell activation;GO:0070301|cellular response to hydrogen peroxide;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0071222|cellular response to lipopolysaccharide;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071349|cellular response to interleukin-12;GO:0071641|negative regulation of macrophage inflammatory protein 1 alpha production;GO:0071650|negative regulation of chemokine (C-C motif) ligand 5 production;GO:0097530|granulocyte migration;GO:1900016|negative regulation of cytokine production involved in inflammatory response;GO:1903720|negative regulation of I-kappaB phosphorylation;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;","GO:0005515|protein binding;GO:0017124|SH3 domain binding;GO:0019903|protein phosphatase binding;GO:0030695|GTPase regulator activity;GO:0045309|protein phosphorylated amino acid binding;GO:0086080|protein binding involved in heterotypic cell-cell adhesion;GO:0098632|cell-cell adhesion mediator activity;GO:1990405|protein antigen binding;GO:1990782|protein tyrosine kinase binding;","K06551","SIRPA_B1_G, CD172; signal-regulatory protein alpha/beta1/gamma"]
["ENSRNOG00000008005",507,42.09451689,217,13.95970509,3.015430242,1.592363861,{"v":3.26733e-46,"d":"3.27E-46"},{"v":2.5262e-45,"d":"2.53E-45"},"up","yes","Akna","protein_coding","chr5:76777415-76816017:-","gi|157822031|ref|NP_001102138.1|",6575,0,"AT-hook-containing transcription factor [Rattus norvegicus]","gi|157822030|ref|NM_001108668.1|",5353,0,"Rattus norvegicus AT-hook transcription factor (Akna), mRNA","Q80VW7",2062,0,"AT-hook-containing transcription factor",".",".",".",".","pfam12443","AKNA","AT-hook-containing transcription factor. This domain family is found in eukaryotes, and is approximately 110 amino acids in length. This family contains a transcription factor which regulates the expression of the costimulatory molecules on lymphocytes.","GO:0001837|epithelial to mesenchymal transition;GO:0021849|neuroblast division in subventricular zone;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050727|regulation of inflammatory response;GO:0060232|delamination;GO:0060234|neuroblast delamination;","GO:0001650|fibrillar center;GO:0005654|nucleoplasm;GO:0005813|centrosome;GO:0005814|centriole;GO:0005829|cytosol;GO:0005874|microtubule;GO:0043231|intracellular membrane-bounded organelle;",".","K21404","AKNA; AT-hook-containing transcription factor"]
["ENSRNOG00000010165",409,33.95790415,146,9.392243975,3.615526199,1.85420563,{"v":3.64753e-46,"d":"3.65E-46"},{"v":2.81675e-45,"d":"2.82E-45"},"up","yes","Tnfaip2","protein_coding","chr6:130476889-130489914:+","gi|212549631|ref|NP_001131105.1|",3147,0,"tumor necrosis factor alpha-induced protein 2 [Rattus norvegicus]","gi|212549630|ref|NM_001137633.1|",2312,0,"Rattus norvegicus TNF alpha induced protein 2 (Tnfaip2), mRNA","Q61333",1082,0,"Tumor necrosis factor alpha-induced protein 2",".",".",".",".","pfam06046","Sec6","Exocyst complex component Sec6. Sec6 is a component of the multiprotein exocyst complex. Sec6 interacts with Sec8, Sec10 and Exo70.These exocyst proteins localize to regions of active exocytosis-at the growing ends of interphase cells and in the medial region of cells undergoing cytokinesis-in an F-actin-dependent and exocytosis- independent manner.","GO:0006887|exocytosis;GO:0051601|exocyst localization;","GO:0000145|exocyst;","GO:0000149|SNARE binding;","K19989","TNFAIP2, EXOC3L3; tumor necrosis factor alpha-induced protein 2"]
["ENSRNOG00000015894",468,38.85647713,189,12.15845282,3.195840598,1.676195452,{"v":6.3314e-46,"d":"6.33E-46"},{"v":4.85998e-45,"d":"4.86E-45"},"up","yes","Dock8","protein_coding","chr1:222649309-222842474:+","gi|197927178|ref|NP_001032882.2|",10548,0,"dedicator of cytokinesis protein 8 [Rattus norvegicus]","gi|672040011|ref|XM_008760310.1|",7223,0,"PREDICTED: Rattus norvegicus dedicator of cytokinesis 8 (Dock8), transcript variant X3, mRNA","Q8C147",3985,0,"Dedicator of cytokinesis protein 8",".",".",".",".","pfam06920","Ded_cyto","Dedicator of cytokinesis. This family represents a conserved region approximately 200 residues long within a number of eukaryotic dedicator of cytokinesis proteins. These are potential guanine nucleotide exchange factors, which activate some small GTPases by exchanging bound GDP for free GTP.","GO:0001771|immunological synapse formation;GO:0007264|small GTPase mediated signal transduction;GO:0036336|dendritic cell migration;GO:0043547|positive regulation of GTPase activity;GO:0061485|memory T cell proliferation;GO:0070233|negative regulation of T cell apoptotic process;GO:1903905|positive regulation of establishment of T cell polarity;GO:1990869|cellular response to chemokine;GO:2000406|positive regulation of T cell migration;","GO:0005737|cytoplasm;GO:0031252|cell leading edge;GO:0031256|leading edge membrane;","GO:0005085|guanyl-nucleotide exchange factor activity;","K21852","DOCK6_7_8; dedicator of cytokinesis protein 6/7/8"]
["ENSRNOG00000016469",446,37.02989059,173,11.12916581,3.327283575,1.734344828,{"v":6.39455E-46,"d":"6.39E-46"},{"v":4.90257E-45,"d":"4.90E-45"},"up","yes","Fxyd2","protein_coding","chr8:45712903-45720203:+","gi|149041525|gb|EDL95366.1|",379,{"v":1E-42,"d":"1.00E-42"},"FXYD domain-containing ion transport regulator 2, isoform CRA_c [Rattus norvegicus]","gi|56299|emb|X70062.1|",484,0,"R.norvegicus mRNA for gamma subunit of sodium potassium ATPase","Q04679",104,{"v":1E-26,"d":"1.00E-26"},"Sodium/potassium-transporting ATPase subunit gamma",".",".",".",".","pfam02038","ATP1G1_PLM_MAT8","ATP1G1/PLM/MAT8 family.","GO:0006813|potassium ion transport;GO:0006814|sodium ion transport;GO:0008285|negative regulation of cell proliferation;GO:0071475|cellular hyperosmotic salinity response;GO:0098662|inorganic cation transmembrane transport;GO:1903406|regulation of sodium:potassium-exchanging ATPase activity;GO:1903407|negative regulation of sodium:potassium-exchanging ATPase activity;GO:2000649|regulation of sodium ion transmembrane transporter activity;","GO:0005886|plasma membrane;GO:0005890|sodium:potassium-exchanging ATPase complex;GO:0016020|membrane;GO:0016323|basolateral plasma membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0005515|protein binding;GO:0017080|sodium channel regulator activity;","K01538","FXYD2, ATP1G1; sodium/potassium-transporting ATPase subunit gamma (FXYD domain-containing ion transport regulator 2)"]
["ENSRNOG00000000569",614,50.97836956,302,19.42779233,2.623991892,1.391763262,{"v":7.59967e-46,"d":"7.60E-46"},{"v":5.81257e-45,"d":"5.81E-45"},"up","yes","Vsir","protein_coding","chr20:28281596-28303878:+","gi|564397877|ref|XP_006256488.1|",1504,0,"PREDICTED: platelet receptor Gi24 isoform X1 [Rattus norvegicus]","gi|672086369|ref|XM_006256426.2|",1895,0,"PREDICTED: Rattus norvegicus hypothetical protein LOC690899 (MGC112715), transcript variant X1, mRNA","Q9D659",483,{"v":7e-166,"d":"7.00E-166"},"V-type immunoglobulin domain-containing suppressor of T-cell activation",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.","GO:0002725|negative regulation of T cell cytokine production;GO:0010628|positive regulation of gene expression;GO:0010950|positive regulation of endopeptidase activity;GO:0030335|positive regulation of cell migration;GO:0030509|BMP signaling pathway;GO:0030513|positive regulation of BMP signaling pathway;GO:0031638|zymogen activation;GO:0032689|negative regulation of interferon-gamma production;GO:0032693|negative regulation of interleukin-10 production;GO:0032700|negative regulation of interleukin-17 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0045591|positive regulation of regulatory T cell differentiation;GO:0048863|stem cell differentiation;GO:0120158|positive regulation of collagen catabolic process;GO:2000562|negative regulation of CD4-positive, alpha-beta T cell proliferation;GO:2000565|negative regulation of CD8-positive, alpha-beta T cell proliferation;GO:2000738|positive regulation of stem cell differentiation;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0019899|enzyme binding;GO:0042802|identical protein binding;GO:0061133|endopeptidase activator activity;","K23268","VSIR, VISTA; V-type immunoglobulin domain-containing suppressor of T-cell activation"]
["ENSRNOG00000020272",237,19.67731854,41,2.637547966,7.460459033,2.8992644,{"v":1.48895E-45,"d":"1.49E-45"},{"v":1.13474e-44,"d":"1.13E-44"},"up","yes","ENSRNOG00000020272","protein_coding","chr2:196091646-196168716:-","gi|568922649|ref|XP_006501474.1|",5237,0,"PREDICTED: UPF0577 protein KIAA1324 isoform X2 [Mus musculus]","gi|672043955|ref|XR_591282.1|",3350,0,"PREDICTED: Rattus norvegicus similar to KIAA1324 protein (RGD1310209), transcript variant X1, misc_RNA","A2AFS3",2006,0,"UPF0577 protein KIAA1324",".",".",".",".","pfam03302","VSP","Giardia variant-specific surface protein.","GO:0000045|autophagosome assembly;GO:0009267|cellular response to starvation;GO:0044090|positive regulation of vacuole organization;GO:2000786|positive regulation of autophagosome assembly;","GO:0005764|lysosome;GO:0005770|late endosome;GO:0005802|trans-Golgi network;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;",".",".","."]
["ENSRNOG00000015674",357,29.64051781,113,7.269339515,4.077470552,2.027674458,{"v":2.09278e-45,"d":"2.09E-45"},{"v":1.58736E-44,"d":"1.59E-44"},"up","yes","Acap1","protein_coding","chr10:54605323-54619472:-","gi|300390201|ref|NP_001099266.2|",3566,0,"arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 [Rattus norvegicus]","gi|300390200|ref|NM_001105796.2|",2468,0,"Rattus norvegicus ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 (Acap1), mRNA","Q8K2H4",1313,0,"Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1","SPBC17G9.08c_2",97.1,{"v":2e-21,"d":"2.00E-21"},"COG5347","pfam01412","ArfGap","Putative GTPase activating protein for Arf. Putative zinc fingers with GTPase activating proteins (GAPs) towards the small GTPase, Arf. The GAP of ARD1 stimulates GTPase hydrolysis for ARD1 but not ARFs.","GO:0050790|regulation of catalytic activity;",".","GO:0005096|GTPase activator activity;GO:0046872|metal ion binding;","K12489","ACAP; Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein"]
["ENSRNOG00000020151",374,31.05197104,125,8.041304773,3.861558778,1.949183331,{"v":3.53641e-45,"d":"3.54E-45"},{"v":2.66653e-44,"d":"2.67E-44"},"up","yes","Cdh1","protein_coding","chr19:34492371-34561775:+","gi|13786164|ref|NP_112624.1|",3917,0,"cadherin-1 precursor [Rattus norvegicus]","gi|13786163|ref|NM_031334.1|",4097,0,"Rattus norvegicus cadherin 1 (Cdh1), mRNA","Q9R0T4",1513,0,"Cadherin-1",".",".",".",".","pfam01049","Cadherin_C","Cadherin cytoplasmic region. Cadherins are vital in cell-cell adhesion during tissue differentiation. Cadherins are linked to the cytoskeleton by catenins. Catenins bind to the cytoplasmic tail of the cadherin. Cadherins cluster to form foci of homophilic binding units. A key determinant to the strength of the binding that it is mediated by cadherins is the juxtamembrane region of the cadherin. This region induces clustering and also binds to the protein p120ctn.","GO:0001701|in utero embryonic development;GO:0001829|trophectodermal cell differentiation;GO:0003382|epithelial cell morphogenesis;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007416|synapse assembly;GO:0007566|embryo implantation;GO:0007605|sensory perception of sound;GO:0009410|response to xenobiotic stimulus;GO:0009636|response to toxic substance;GO:0010033|response to organic substance;GO:0010468|regulation of gene expression;GO:0010955|negative regulation of protein processing;GO:0016339|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0019538|protein metabolic process;GO:0021983|pituitary gland development;GO:0022408|negative regulation of cell-cell adhesion;GO:0022409|positive regulation of cell-cell adhesion;GO:0030336|negative regulation of cell migration;GO:0031175|neuron projection development;GO:0031532|actin cytoskeleton reorganization;GO:0032880|regulation of protein localization;GO:0033561|regulation of water loss via skin;GO:0034332|adherens junction organization;GO:0035847|uterine epithelium development;GO:0042307|positive regulation of protein import into nucleus;GO:0043281|regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0044331|cell-cell adhesion mediated by cadherin;GO:0045893|positive regulation of transcription, DNA-templated;GO:0046697|decidualization;GO:0050680|negative regulation of epithelial cell proliferation;GO:0060576|intestinal epithelial cell development;GO:0060662|salivary gland cavitation;GO:0060693|regulation of branching involved in salivary gland morphogenesis;GO:0070830|bicellular tight junction assembly;GO:0071230|cellular response to amino acid stimulus;GO:0071285|cellular response to lithium ion;GO:0071681|cellular response to indole-3-methanol;GO:0072659|protein localization to plasma membrane;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0090102|cochlea development;GO:0098609|cell-cell adhesion;GO:0098742|cell-cell adhesion via plasma-membrane adhesion molecules;GO:0099576|regulation of protein catabolic process at postsynapse, modulating synaptic transmission;GO:1903077|negative regulation of protein localization to plasma membrane;GO:2000008|regulation of protein localization to cell surface;GO:2001222|regulation of neuron migration;","GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005802|trans-Golgi network;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0005912|adherens junction;GO:0009898|cytoplasmic side of plasma membrane;GO:0009986|cell surface;GO:0015629|actin cytoskeleton;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016328|lateral plasma membrane;GO:0016342|catenin complex;GO:0016600|flotillin complex;GO:0030027|lamellipodium;GO:0030054|cell junction;GO:0030424|axon;GO:0030864|cortical actin cytoskeleton;GO:0033268|node of Ranvier;GO:0043219|lateral loop;GO:0043220|Schmidt-Lanterman incisure;GO:0043296|apical junction complex;GO:0043679|axon terminus;GO:0045177|apical part of cell;GO:0048471|perinuclear region of cytoplasm;GO:0071944|cell periphery;GO:0098794|postsynapse;GO:0098978|glutamatergic synapse;","GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0008013|beta-catenin binding;GO:0008092|cytoskeletal protein binding;GO:0019903|protein phosphatase binding;GO:0019904|protein domain specific binding;GO:0030506|ankyrin binding;GO:0032794|GTPase activating protein binding;GO:0042802|identical protein binding;GO:0045294|alpha-catenin binding;GO:0045295|gamma-catenin binding;GO:0045296|cadherin binding;GO:0050839|cell adhesion molecule binding;","K05689","CDH1, CDHE, CD324; cadherin 1, type 1, E-cadherin"]
["ENSRNOG00000053661",411,34.12395748,153,9.842557042,3.466980921,1.793679897,{"v":2.11446e-44,"d":"2.11E-44"},{"v":1.57945e-43,"d":"1.58E-43"},"up","yes","Klra17","protein_coding","chr4:163368380-163455261:-","gi|672051537|ref|XP_008761655.1|",1409,0,"PREDICTED: killer cell lectin-like receptor 7 isoform X6 [Rattus norvegicus]","gi|672018818|ref|XM_003753951.3|",1045,0,"PREDICTED: Rattus norvegicus similar to immunoreceptor Ly49si3 (LOC690097), transcript variant X1, mRNA","Q60654",309,{"v":6e-101,"d":"6.00E-101"},"Killer cell lectin-like receptor 7",".",".",".",".","pfam08391","Ly49","Ly49-like protein, N-terminal region. The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000027096",276,22.9153583,65,4.181478482,5.480204766,2.4542298,{"v":2.12334E-44,"d":"2.12E-44"},{"v":1.58423E-43,"d":"1.58E-43"},"up","yes","Ctsw","protein_coding","chr1:202772572-202775964:-","gi|66730453|ref|NP_001019413.1|",1827,0,"cathepsin W precursor [Rattus norvegicus]","gi|66730452|ref|NM_001024242.1|",1245,0,"Rattus norvegicus cathepsin W (Ctsw), mRNA","P56203",611,0,"Cathepsin W","MA3430_1",57.8,3e-08,"COG4870","pfam00112","Peptidase_C1","Papain family cysteine protease.","GO:0051603|proteolysis involved in cellular protein catabolic process;","GO:0005615|extracellular space;GO:0005764|lysosome;","GO:0004197|cysteine-type endopeptidase activity;","K08569","CTSW; cathepsin W [EC:3.4.22.-]"]
["ENSRNOG00000004772",291,24.16075821,74,4.760452426,5.075307146,2.343495133,{"v":2.35104e-44,"d":"2.35E-44"},{"v":1.75207e-43,"d":"1.75E-43"},"up","yes","Cytip","protein_coding","chr3:42698768-42725993:-","gi|58865742|ref|NP_001012086.1|",1581,0,"cytohesin-interacting protein [Rattus norvegicus]","gi|58865741|ref|NM_001012086.1|",1664,0,"Rattus norvegicus cytohesin 1 interacting protein (Cytip), mRNA","Q5I0L6",613,0,"Cytohesin-interacting protein",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.","GO:0030155|regulation of cell adhesion;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005769|early endosome;GO:0005829|cytosol;GO:0005938|cell cortex;",".",".","."]
["ENSRNOG00000019614",223,18.5149453,36,2.315895775,7.994723035,2.999048055,{"v":2.36261e-44,"d":"2.36E-44"},{"v":1.75865E-43,"d":"1.76E-43"},"up","yes","Ptpn22","protein_coding","chr2:191366808-191414779:+","gi|157824150|ref|NP_001099930.1|",4102,0,"tyrosine-protein phosphatase non-receptor type 22 [Rattus norvegicus]","gi|157824149|ref|NM_001106460.1|",2747,0,"Rattus norvegicus protein tyrosine phosphatase, non-receptor type 22 (Ptpn22), mRNA","P29352",1358,0,"Tyrosine-protein phosphatase non-receptor type 22","SPAC19D5.01",120,{"v":4e-27,"d":"4.00E-27"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0002230|positive regulation of defense response to virus by host;GO:0002685|regulation of leukocyte migration;GO:0006470|protein dephosphorylation;GO:0010507|negative regulation of autophagy;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0030217|T cell differentiation;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0032481|positive regulation of type I interferon production;GO:0032496|response to lipopolysaccharide;GO:0032715|negative regulation of interleukin-6 production;GO:0032717|negative regulation of interleukin-8 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032727|positive regulation of interferon-alpha production;GO:0032728|positive regulation of interferon-beta production;GO:0032729|positive regulation of interferon-gamma production;GO:0032817|regulation of natural killer cell proliferation;GO:0034141|positive regulation of toll-like receptor 3 signaling pathway;GO:0034145|positive regulation of toll-like receptor 4 signaling pathway;GO:0034157|positive regulation of toll-like receptor 7 signaling pathway;GO:0034165|positive regulation of toll-like receptor 9 signaling pathway;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0035644|phosphoanandamide dephosphorylation;GO:0042307|positive regulation of protein import into nucleus;GO:0043508|negative regulation of JUN kinase activity;GO:0050730|regulation of peptidyl-tyrosine phosphorylation;GO:0050852|T cell receptor signaling pathway;GO:0050860|negative regulation of T cell receptor signaling pathway;GO:0050868|negative regulation of T cell activation;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070433|negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0071225|cellular response to muramyl dipeptide;GO:0071663|positive regulation of granzyme B production;GO:1901222|regulation of NIK/NF-kappaB signaling;GO:1902523|positive regulation of protein K63-linked ubiquitination;GO:1903169|regulation of calcium ion transmembrane transport;GO:1903753|negative regulation of p38MAPK cascade;GO:2000566|positive regulation of CD8-positive, alpha-beta T cell proliferation;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0009898|cytoplasmic side of plasma membrane;GO:0048471|perinuclear region of cytoplasm;","GO:0004725|protein tyrosine phosphatase activity;GO:0004726|non-membrane spanning protein tyrosine phosphatase activity;GO:0016791|phosphatase activity;GO:0017124|SH3 domain binding;GO:0019900|kinase binding;GO:0031625|ubiquitin protein ligase binding;GO:1990782|protein tyrosine kinase binding;","K18024","PTPN12_18_22; tyrosine-protein phosphatase non-receptor type 12/18/22 [EC:3.1.3.48]"]
["ENSRNOG00000004670",792,65.75711514,459,29.52767113,2.226965847,1.155079433,{"v":2.8056e-44,"d":"2.81E-44"},{"v":2.08113e-43,"d":"2.08E-43"},"up","yes","Ddx56","protein_coding","chr14:81112012-81122333:-","gi|564384783|ref|XP_006251499.1|",2745,0,"PREDICTED: probable ATP-dependent RNA helicase DDX56 isoform X1 [Rattus norvegicus]","gi|298900727|emb|FQ212430.1|",2775,0,"Rattus norvegicus TL0AAA55YE03 mRNA sequence","Q9D0R4",1025,0,"Probable ATP-dependent RNA helicase DDX56",".",".",".",".","pfam00270","DEAD","DEAD/DEAH box helicase. Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolizm, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.","GO:0010976|positive regulation of neuron projection development;","GO:0005575|cellular_component;GO:0005730|nucleolus;","GO:0003674|molecular_function;GO:0003676|nucleic acid binding;GO:0003724|RNA helicase activity;GO:0005524|ATP binding;GO:0016787|hydrolase activity;","K14810","DDX56, DBP9; ATP-dependent RNA helicase DDX56/DBP9 [EC:3.6.4.13]"]
["ENSRNOG00000064497",183,15.19387888,17,1.093617449,13.89323011,3.796310153,{"v":3.02672e-44,"d":"3.03E-44"},{"v":2.24255e-43,"d":"2.24E-43"},"up","yes","Olr1585","protein_coding","chr13:86009008-86073347:+","gi|47576433|ref|NP_001001109.1|",1508,0,"olfactory receptor Olr1585 [Rattus norvegicus]","gi|672074948|ref|XM_008769791.1|",3320,0,"PREDICTED: Rattus norvegicus olfactory receptor 1587 (Olr1587), transcript variant X1, mRNA","P11369",222,{"v":2e-128,"d":"2.00E-128"},"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.",".",".",".",".","."]
["ENSRNOG00000016794",682,56.62418248,366,23.54494038,2.404940576,1.266001247,{"v":4.39444e-44,"d":"4.39E-44"},{"v":3.24463e-43,"d":"3.24E-43"},"up","yes","Phyhd1","protein_coding","chr3:13540056-13553797:+","gi|564339943|ref|XP_006233839.1|",1565,0,"PREDICTED: phytanoyl-CoA dioxygenase domain-containing protein 1 isoform X2 [Rattus norvegicus]","gi|672044897|ref|XM_006233779.2|",984,0,"PREDICTED: Rattus norvegicus phytanoyl-CoA dioxygenase domain containing 1 (Phyhd1), transcript variant X3, mRNA","Q5BJP9",575,0,"Phytanoyl-CoA dioxygenase domain-containing protein 1","all4427",56.6,7e-08,"COG5285","pfam05721","PhyH","Phytanoyl-CoA dioxygenase (PhyH). This family is made up of several eukaryotic phytanoyl-CoA dioxygenase (PhyH) proteins, ectoine hydroxylases and a number of bacterial deoxygenases. PhyH is a peroxisomal enzyme catalyzing the first step of phytanic acid alpha-oxidation. PhyH deficiency causes Refsum's disease (RD) which is an inherited neurological syndrome biochemically characterized by the accumulation of phytanic acid in plasma and tissues.",".",".","GO:0016706|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0046872|metal ion binding;",".","."]
["ENSRNOG00000049282",162,13.45031901,8,0.514643505,26.13521566,4.707923159,{"v":6.225E-44,"d":"6.23E-44"},{"v":4.57509e-43,"d":"4.58E-43"},"up","yes","Oas2","protein_coding","chr12:35806759-35829371:+","gi|57527617|ref|NP_001009715.1|",3782,0,"2'-5'-oligoadenylate synthase 2 [Rattus norvegicus]","gi|37921529|gb|AY230746.1|",2308,0,"Rattus norvegicus 2'-5' oligoadenylate synthetase 2 (Oas2) mRNA, complete cds","Q5MYU0",1461,0,"2'-5'-oligoadenylate synthase 2",".",".",".",".","pfam10421","OAS1_C","2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus. This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between 320 and 344 at the extreme C-terminal end. Oligoadenylate synthetases are antiviral enzymes that counteract vial attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesize 2'.5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication. This domain is often associated with NTP_transf_2 pfam01909.","GO:0006401|RNA catabolic process;GO:0009615|response to virus;GO:0009617|response to bacterium;GO:0032728|positive regulation of interferon-beta production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0042742|defense response to bacterium;GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0051607|defense response to virus;GO:0060337|type I interferon signaling pathway;GO:0060700|regulation of ribonuclease activity;GO:0070106|interleukin-27-mediated signaling pathway;GO:1903487|regulation of lactation;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016020|membrane;GO:0048471|perinuclear region of cytoplasm;","GO:0001730|2'-5'-oligoadenylate synthetase activity;GO:0003725|double-stranded RNA binding;GO:0005524|ATP binding;GO:0046872|metal ion binding;","K14216","OAS; 2'-5'-oligoadenylate synthetase [EC:2.7.7.84]"]
["ENSRNOG00000064184",161,13.36729234,8,0.514643505,25.97388717,4.698990034,{"v":1.21322E-43,"d":"1.21E-43"},{"v":8.89614e-43,"d":"8.90E-43"},"up","yes","Phf11b","protein_coding","chr15:33363395-33378606:-","gi|62079205|ref|NP_001014257.1|",1344,0,"PHD finger protein 11-like [Rattus norvegicus]","gi|62079204|ref|NM_001014235.1|",1155,0,"Rattus norvegicus PHD finger protein 11B (Phf11b), mRNA","Q5I0J8",522,0,"PHD finger protein 11-like",".",".",".",".","pfam13771","zf-HC5HC2H","PHD-like zinc-binding domain. The members of this family are annotated as containing PHD domain, but the zinc-binding region here is not typical of PHD domains. The conformation here is a well-conserved cysteine-histidine rich region spanning 90 residues, where the Cys and His are arranged as HxxC(31)CxxC(6)CxxCxxxxCxxxxHxxC (21)CxxH.",".",".",".",".","."]
["ENSRNOG00000054218",185,15.3599322,19,1.222278326,12.56664041,3.651527103,{"v":1.53295E-43,"d":"1.53E-43"},{"v":1.12149e-42,"d":"1.12E-42"},"up","yes","Il18rap","protein_coding","chr9:42768220-42800959:+","gi|672023954|ref|XP_008756243.1|",3282,0,"PREDICTED: interleukin-18 receptor accessory protein [Rattus norvegicus]","gi|672023953|ref|XM_008758021.1|",2265,0,"PREDICTED: Rattus norvegicus interleukin 18 receptor accessory protein (Il18rap), mRNA","Q9Z2B1",1088,0,"Interleukin-18 receptor accessory protein",".",".",".",".","pfam01582","TIR","TIR domain. The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.","GO:0008283|cell proliferation;GO:0035655|interleukin-18-mediated signaling pathway;GO:0042119|neutrophil activation;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0070301|cellular response to hydrogen peroxide;GO:0071345|cellular response to cytokine stimulus;GO:0071351|cellular response to interleukin-18;","GO:0005575|cellular_component;GO:0045092|interleukin-18 receptor complex;","GO:0003953|NAD+ nucleosidase activity;GO:0042007|interleukin-18 binding;GO:0042008|interleukin-18 receptor activity;","K05174","IL18RAP, ACPL, CD218b; interleukin 18 receptor accessory protein"]
["ENSRNOG00000005378",187,15.52598552,20,1.286608764,12.06737118,3.593039521,{"v":1.73219e-43,"d":"1.73E-43"},{"v":1.26436E-42,"d":"1.26E-42"},"up","yes","Gna15","protein_coding","chr7:8184861-8205508:+","gi|149034406|gb|EDL89143.1|",1864,0,"guanine nucleotide binding protein, alpha 15 [Rattus norvegicus]","gi|672057901|ref|XM_006241021.2|",1799,0,"PREDICTED: Rattus norvegicus guanine nucleotide binding protein, alpha 15 (Gna15), transcript variant X1, mRNA","O88302",721,0,"Guanine nucleotide-binding protein subunit alpha-15",".",".",".",".","pfam00503","G-alpha","G-protein alpha subunit. G proteins couple receptors of extracellular signals to intracellular signaling pathways. The G protein alpha subunit binds guanyl nucleotide and is a weak GTPase. A set of residues that are unique to G-alpha as compared to its ancestor the Arf-like family form a ring of residues centered on the nucleotide binding site. A Ggamma is found fused to an inactive Galpha in the Dictyostelium protein gbqA.","GO:0001508|action potential;GO:0007188|adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0051482|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway;GO:0060158|phospholipase C-activating dopamine receptor signaling pathway;","GO:0005834|heterotrimeric G-protein complex;GO:0016020|membrane;","GO:0001664|G protein-coupled receptor binding;GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0019001|guanyl nucleotide binding;GO:0031683|G-protein beta/gamma-subunit complex binding;GO:0046872|metal ion binding;","K04637","GNA15; guanine nucleotide-binding protein subunit alpha-15"]
["ENSRNOG00000015821",188,15.60901218,21,1.350939202,11.55419293,3.530344585,{"v":3.77677e-43,"d":"3.78E-43"},{"v":2.7411e-42,"d":"2.74E-42"},"up","yes","Cd2","protein_coding","chr2:188710900-188724026:-","gi|56972388|gb|AAH88164.1|",1466,0,"Cd2 molecule [Rattus norvegicus]","gi|6978626|ref|NM_012830.1|",1121,0,"Rattus norvegicus Cd2 molecule (Cd2), mRNA","P08921",569,0,"T-cell surface antigen CD2",".",".",".",".","pfam05790","C2-set","Immunoglobulin C2-set domain.","GO:0032729|positive regulation of interferon-gamma production;GO:0032757|positive regulation of interleukin-8 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0034113|heterotypic cell-cell adhesion;GO:0042110|T cell activation;GO:0098609|cell-cell adhesion;","GO:0005576|extracellular region;GO:0005911|cell-cell junction;GO:0009897|external side of plasma membrane;GO:0009898|cytoplasmic side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0032991|protein-containing complex;GO:0045121|membrane raft;GO:0046658|anchored component of plasma membrane;","GO:0005102|signaling receptor binding;GO:0005515|protein binding;GO:0019901|protein kinase binding;GO:0030971|receptor tyrosine kinase binding;GO:0042802|identical protein binding;GO:0043621|protein self-association;","K06449","CD2; T-cell surface glycoprotein CD2"]
["ENSRNOG00000064682",271,22.500225,65,4.181478482,5.380925694,2.427854385,{"v":4.154e-43,"d":"4.15E-43"},{"v":3.01146e-42,"d":"3.01E-42"},"up","yes","ENSRNOG00000064682","lncRNA","chr13:82486637-82523851:+","gi|62659813|ref|XP_577285.1|",350,{"v":5e-34,"d":"5.00E-34"},"PREDICTED: SH2 domain-containing protein 1B isoform X2 [Rattus norvegicus]","gi|672027333|ref|XR_592058.1|",2293,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103692075 (LOC103692075), ncRNA","O35324",114,{"v":6e-27,"d":"6.00E-27"},"SH2 domain-containing protein 1B",".",".",".",".","pfam14868","DUF4487","Domain of unknown function (DUF4487). This family of proteins is found in eukaryotes. Proteins in this family are typically between 209 and 938 amino acids in length. There is a conserved WCF sequence motif. There is a single completely conserved residue W that may be functionally important.",".",".",".",".","."]
["ENSRNOG00000015184",218,18.09981199,36,2.315895775,7.815469156,2.96633248,{"v":5.85595e-43,"d":"5.86E-43"},{"v":4.24049e-42,"d":"4.24E-42"},"up","yes","Clic3","protein_coding","chr3:8272097-8274018:+","gi|672044646|ref|XP_008759806.1|",1416,0,"PREDICTED: chloride intracellular channel protein 3 isoform X1 [Rattus norvegicus]","gi|672044645|ref|XM_008761584.1|",1460,0,"PREDICTED: Rattus norvegicus chloride intracellular channel 3 (Clic3), transcript variant X1, mRNA","Q9D7P7",441,{"v":5e-152,"d":"5.00E-152"},"Chloride intracellular channel protein 3",".",".",".",".","pfam13409","GST_N_2","Glutathione S-transferase, N-terminal domain. This family is closely related to pfam02798.","GO:0006749|glutathione metabolic process;GO:0006821|chloride transport;GO:0034220|ion transmembrane transport;GO:0034765|regulation of ion transmembrane transport;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0016020|membrane;GO:0016604|nuclear body;GO:0034707|chloride channel complex;","GO:0005244|voltage-gated ion channel activity;GO:0005254|chloride channel activity;","K05023","CLIC3; chloride intracellular channel protein 3"]
["ENSRNOG00000006557",523,43.42294345,242,15.56796604,2.789249626,1.479877055,{"v":6.11862e-43,"d":"6.12E-43"},{"v":4.42569e-42,"d":"4.43E-42"},"up","yes","Cyfip2","protein_coding","chr10:30621318-30741113:-","gi|39104558|dbj|BAC41472.2|",6724,0,"mKIAA1168 protein [Mus musculus]","gi|157819570|ref|NM_001106996.1|",5249,0,"Rattus norvegicus cytoplasmic FMR1 interacting protein 2 (Cyfip2), mRNA","Q5SQX6",2585,0,"Cytoplasmic FMR1-interacting protein 2",".",".",".",".","pfam05994","FragX_IP","Cytoplasmic Fragile-X interacting family. CYFIP1/2 (Cytoplasmic fragile X mental retardation interacting protein) like proteins for a highly conserved protein family. The function of CYFIPs is unclear, but CYFIP interaction with fragile X mental retardation interacting protein (FMRP) involves the domain of FMRP which also mediating homo- and heteromerization.","GO:0000902|cell morphogenesis;GO:0006915|apoptotic process;GO:0030833|regulation of actin filament polymerization;GO:0031175|neuron projection development;GO:0045862|positive regulation of proteolysis;GO:0051388|positive regulation of neurotrophin TRK receptor signaling pathway;GO:0097202|activation of cysteine-type endopeptidase activity;GO:0097484|dendrite extension;GO:0098609|cell-cell adhesion;","GO:0005737|cytoplasm;GO:0031209|SCAR complex;GO:0045202|synapse;GO:0048471|perinuclear region of cytoplasm;","GO:0031267|small GTPase binding;","K05749","CYFIP; cytoplasmic FMR1 interacting protein"]
["ENSRNOG00000065195",234,19.42823856,45,2.894869718,6.711265257,2.746584779,{"v":1.12987E-42,"d":"1.13E-42"},{"v":8.14485e-42,"d":"8.14E-42"},"up","yes","ENSRNOG00000065195","protein_coding","chr6:131831454-131854463:-","gi|672057367|ref|XP_008763214.1|",26725,0,"PREDICTED: protein AHNAK2 isoform X2, partial [Rattus norvegicus]","gi|672057366|ref|XM_008764992.1|",9105,0,"PREDICTED: Rattus norvegicus AHNAK nucleoprotein 2 (Ahnak2), transcript variant X2, partial mRNA","Q8IVF2",3713,0,"Protein AHNAK2",".",".",".",".","pfam05109","Herpes_BLLF1","Herpes virus major outer envelope glycoprotein (BLLF1). This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralizing antibodies in vivo.",".",".",".",".","."]
["ENSRNOG00000025297",262,21.75298506,61,3.924156729,5.543352766,2.47075882,{"v":1.50496e-42,"d":"1.50E-42"},{"v":1.08122E-41,"d":"1.08E-41"},"up","yes","Gpr171","protein_coding","chr2:143359564-143366698:-","gi|157824140|ref|NP_001102980.1|",1639,0,"probable G-protein coupled receptor 171 [Rattus norvegicus]","gi|157824139|ref|NM_001109510.1|",1640,0,"Rattus norvegicus G protein-coupled receptor 171 (Gpr171), mRNA","Q8BG55",585,0,"Probable G-protein coupled receptor 171",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0035589|G protein-coupled purinergic nucleotide receptor signaling pathway;GO:0045638|negative regulation of myeloid cell differentiation;","GO:0016021|integral component of membrane;","GO:0045028|G protein-coupled purinergic nucleotide receptor activity;","K08441","GPR171; G protein-coupled receptor 171"]
["ENSRNOG00000057058",427,35.45238404,171,11.00050493,3.222796069,1.688312901,{"v":1.80994e-42,"d":"1.81E-42"},{"v":1.29887e-41,"d":"1.30E-41"},"up","yes","Cd300a","protein_coding","chr10:99929801-99942674:+","gi|329112553|ref|NP_001192277.1|",1401,0,"CMRF35-like molecule 8 precursor [Rattus norvegicus]","gi|329112552|ref|NM_001205348.1|",1514,0,"Rattus norvegicus Cd300a molecule (Cd300a), mRNA","A2TGX5",538,0,"CMRF35-like molecule 8",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0002552|serotonin secretion by mast cell;GO:0006898|receptor-mediated endocytosis;GO:0014063|negative regulation of serotonin secretion;GO:0030889|negative regulation of B cell proliferation;GO:0032516|positive regulation of phosphoprotein phosphatase activity;GO:0033007|negative regulation of mast cell activation involved in immune response;GO:0034125|negative regulation of MyD88-dependent toll-like receptor signaling pathway;GO:0043305|negative regulation of mast cell degranulation;GO:0043407|negative regulation of MAP kinase activity;GO:0048147|negative regulation of fibroblast proliferation;GO:0050856|regulation of T cell receptor signaling pathway;GO:0050859|negative regulation of B cell receptor signaling pathway;GO:0051134|negative regulation of NK T cell activation;GO:0060101|negative regulation of phagocytosis, engulfment;GO:1902564|negative regulation of neutrophil activation;GO:1902567|negative regulation of eosinophil activation;GO:1902569|negative regulation of activation of Janus kinase activity;GO:2000417|negative regulation of eosinophil migration;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0001786|phosphatidylserine binding;GO:0004888|transmembrane signaling receptor activity;GO:0008429|phosphatidylethanolamine binding;GO:0019902|phosphatase binding;GO:0038023|signaling receptor activity;","K06719","CD300; CD300 antigen"]
["ENSRNOG00000066773",571,47.40822316,285,18.33417488,2.585784387,1.370601982,{"v":8.19289e-42,"d":"8.19E-42"},{"v":5.82716e-41,"d":"5.83E-41"},"up","yes","RT1-DMa","protein_coding","chr20:4707028-4710432:-","gi|38454220|ref|NP_942036.1|",1099,{"v":1e-145,"d":"1.00E-145"},"RT1 class II, DM alpha precursor [Rattus norvegicus]","gi|672085841|ref|XM_006256035.2|",693,0,"PREDICTED: Rattus norvegicus class II histocompatibility antigen, M alpha chain-like (LOC100909593), mRNA","P28078",377,{"v":4e-127,"d":"4.00E-127"},"Class II histocompatibility antigen, M alpha chain",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.",".",".",".",".","."]
["ENSRNOG00000006227",503,41.76241024,231,14.86033122,2.810328358,1.490738705,{"v":8.49799e-42,"d":"8.50E-42"},{"v":6.03745e-41,"d":"6.04E-41"},"up","yes","Ifih1","protein_coding","chr3:47227364-47275456:-","gi|157822253|ref|NP_001102669.1|",5320,0,"interferon-induced helicase C domain-containing protein 1 [Rattus norvegicus]","gi|157822252|ref|NM_001109199.1|",3897,0,"Rattus norvegicus interferon induced with helicase C domain 1 (Ifih1), mRNA","Q8R5F7",1915,0,"Interferon-induced helicase C domain-containing protein 1","PH1896m_1",84,{"v":2e-15,"d":"2.00E-15"},"COG1111","pfam11648","RIG-I_C-RD","C-terminal domain of RIG-I. This family of proteins represents the regulatory domain RD of RIG-I, a protein which initiates a signalling cascade that provides essential antiviral protection for the host. The RD domain binds viral RNA, activating the RIG-I ATPase by RNA-dependant dimerization. The structure of RD contains a zinc-binding domain and is thought to confer ligand specificity.","GO:0009615|response to virus;GO:0016925|protein sumoylation;GO:0032727|positive regulation of interferon-alpha production;GO:0032728|positive regulation of interferon-beta production;GO:0032755|positive regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0039530|MDA-5 signaling pathway;GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0051607|defense response to virus;GO:0060760|positive regulation of response to cytokine stimulus;GO:0071360|cellular response to exogenous dsRNA;GO:0098586|cellular response to virus;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;","GO:0003677|DNA binding;GO:0003723|RNA binding;GO:0003724|RNA helicase activity;GO:0003725|double-stranded RNA binding;GO:0003727|single-stranded RNA binding;GO:0005524|ATP binding;GO:0008270|zinc ion binding;GO:0042802|identical protein binding;GO:0043021|ribonucleoprotein complex binding;","K12647","IFIH1, MDA5; interferon-induced helicase C domain-containing protein 1 [EC:3.6.4.13]"]
["ENSRNOG00000050430",280,23.24746495,74,4.760452426,4.883457047,2.287902807,{"v":1.39176e-41,"d":"1.39E-41"},{"v":9.84409e-41,"d":"9.84E-41"},"up","yes","Vav1","protein_coding","chr9:2157900-2208937:+","gi|162287067|ref|NP_036891.2|",4363,0,"proto-oncogene vav [Rattus norvegicus]","gi|162287066|ref|NM_012759.2|",2822,0,"Rattus norvegicus vav guanine nucleotide exchange factor 1 (Vav1), mRNA","P54100",1679,0,"Proto-oncogene vav",".",".",".",".","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0002768|immune response-regulating cell surface receptor signaling pathway;GO:0006909|phagocytosis;GO:0006955|immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007229|integrin-mediated signaling pathway;GO:0007264|small GTPase mediated signal transduction;GO:0008361|regulation of cell size;GO:0030217|T cell differentiation;GO:0030593|neutrophil chemotaxis;GO:0035556|intracellular signal transduction;GO:0042110|T cell activation;GO:0043087|regulation of GTPase activity;GO:0043547|positive regulation of GTPase activity;GO:0045785|positive regulation of cell adhesion;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;GO:0048468|cell development;GO:0072593|reactive oxygen species metabolic process;","GO:0005911|cell-cell junction;","GO:0001784|phosphotyrosine residue binding;GO:0005085|guanyl-nucleotide exchange factor activity;GO:0046872|metal ion binding;GO:0140031|phosphorylation-dependent protein binding;","K05730","VAV; guanine nucleotide exchange factor VAV"]
["ENSRNOG00000034025",531,44.08715674,254,16.3399313,2.698123752,1.43195652,{"v":1.46385e-41,"d":"1.46E-41"},{"v":1.03426e-40,"d":"1.03E-40"},"up","yes","Ptprj","protein_coding","chr3:76405927-76562260:-","gi|309243082|ref|NP_058965.2|",6546,0,"receptor-type tyrosine-protein phosphatase eta [Rattus norvegicus]","gi|309243081|ref|NM_017269.2|",7449,0,"Rattus norvegicus protein tyrosine phosphatase, receptor type, J (Ptprj), mRNA","Q64455",2083,0,"Receptor-type tyrosine-protein phosphatase eta","SPAC11E3.09",151,{"v":2e-38,"d":"2.00E-38"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0001570|vasculogenesis;GO:0001954|positive regulation of cell-matrix adhesion;GO:0006470|protein dephosphorylation;GO:0007507|heart development;GO:0007596|blood coagulation;GO:0008285|negative regulation of cell proliferation;GO:0010572|positive regulation of platelet activation;GO:0010642|negative regulation of platelet-derived growth factor receptor signaling pathway;GO:0010759|positive regulation of macrophage chemotaxis;GO:0030155|regulation of cell adhesion;GO:0030183|B cell differentiation;GO:0030308|negative regulation of cell growth;GO:0030336|negative regulation of cell migration;GO:0032760|positive regulation of tumor necrosis factor production;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0035584|calcium-mediated signaling using intracellular calcium source;GO:0042059|negative regulation of epidermal growth factor receptor signaling pathway;GO:0042593|glucose homeostasis;GO:0043116|negative regulation of vascular permeability;GO:0043407|negative regulation of MAP kinase activity;GO:0043410|positive regulation of MAPK cascade;GO:0045785|positive regulation of cell adhesion;GO:0046627|negative regulation of insulin receptor signaling pathway;GO:0048008|platelet-derived growth factor receptor signaling pathway;GO:0048709|oligodendrocyte differentiation;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050860|negative regulation of T cell receptor signaling pathway;GO:0050918|positive chemotaxis;GO:0051894|positive regulation of focal adhesion assembly;GO:0051897|positive regulation of protein kinase B signaling;GO:0051898|negative regulation of protein kinase B signaling;GO:1905451|positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis;GO:1990264|peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity;GO:2000272|negative regulation of signaling receptor activity;","GO:0001772|immunological synapse;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0032587|ruffle membrane;","GO:0004725|protein tyrosine phosphatase activity;GO:0005161|platelet-derived growth factor receptor binding;GO:0008013|beta-catenin binding;GO:0016791|phosphatase activity;GO:0019901|protein kinase binding;GO:0045295|gamma-catenin binding;GO:0045296|cadherin binding;GO:0051019|mitogen-activated protein kinase binding;GO:0070097|delta-catenin binding;","K05698","PTPRJ, DEP1, CD148; receptor-type tyrosine-protein phosphatase eta [EC:3.1.3.48]"]
["ENSRNOG00000009074",273,22.66627832,70,4.503130673,5.033448942,2.33154728,{"v":1.77439e-41,"d":"1.77E-41"},{"v":1.2509E-40,"d":"1.25E-40"},"up","yes","AABR07017902.1","protein_coding","chr15:27109504-27665579:+","gi|60551424|gb|AAH91200.1|",766,{"v":6e-90,"d":"6.00E-90"},"RGD1359684 protein [Rattus norvegicus]","gi|218511252|gb|AC097037.8|",3033,0,"Rattus norvegicus CH230-20D8 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P01849",223,{"v":5e-65,"d":"5.00E-65"},"T-cell receptor alpha chain C region",".",".",".",".","pfam09291","DUF1968","Domain of unknown function (DUF1968). Members of this family are found in mammalian T-cell antigen receptor, and adopt an immunoglobulin-like beta-sandwich fold, with seven strands in two beta-sheets in a Greek-key topology. Their exact function has not, as yet, been determined.",".",".",".",".","."]
["ENSRNOG00000016581",331,27.48182463,107,6.883356886,3.992503235,1.997293577,{"v":1.94154E-41,"d":"1.94E-41"},{"v":1.36422e-40,"d":"1.36E-40"},"up","yes","Serpinb1a","protein_coding","chr17:31590677-31599102:+","gi|72255515|ref|NP_001026812.1|",1933,0,"leukocyte elastase inhibitor A [Rattus norvegicus]","gi|72255514|ref|NM_001031642.1|",1266,0,"Rattus norvegicus serine (or cysteine) proteinase inhibitor, clade B, member 1a (Serpinb1a), mRNA","Q4G075",746,0,"Leukocyte elastase inhibitor A","MA3388",197,{"v":9e-57,"d":"9.00E-57"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0006954|inflammatory response;GO:0010951|negative regulation of endopeptidase activity;GO:0019725|cellular homeostasis;GO:0032691|negative regulation of interleukin-1 beta production;GO:0042176|regulation of protein catabolic process;GO:0044342|type B pancreatic cell proliferation;GO:0045088|regulation of innate immune response;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005764|lysosome;GO:0005769|early endosome;GO:0036464|cytoplasmic ribonucleoprotein granule;","GO:0004867|serine-type endopeptidase inhibitor activity;GO:0030414|peptidase inhibitor activity;","K23425","SERPINB1; leukocyte elastase inhibitor"]
["ENSRNOG00000006940",303,25.15707814,89,5.725408998,4.39393555,2.135513709,{"v":2.43094e-41,"d":"2.43E-41"},{"v":1.70622E-40,"d":"1.71E-40"},"up","yes","Ncf4","protein_coding","chr7:109826020-109843389:+","gi|187937026|ref|NP_001120776.1|",1771,0,"neutrophil cytosol factor 4 [Rattus norvegicus]","gi|187937025|ref|NM_001127304.1|",1496,0,"Rattus norvegicus neutrophil cytosolic factor 4 (Ncf4), mRNA","P97369",671,0,"Neutrophil cytosol factor 4",".",".",".",".","pfam00787","PX","PX domain. PX domains bind to phosphoinositides.","GO:0006909|phagocytosis;GO:0042554|superoxide anion generation;GO:0045730|respiratory burst;GO:0050790|regulation of catalytic activity;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0010008|endosome membrane;GO:0016020|membrane;GO:0043020|NADPH oxidase complex;","GO:0016176|superoxide-generating NADPH oxidase activator activity;GO:0032266|phosphatidylinositol-3-phosphate binding;","K08012","NCF4, P40PHOX; neutrophil cytosolic factor 4"]
["ENSRNOG00000007372",468,38.85647713,206,13.25207027,2.93210618,1.551937349,{"v":2.76371E-41,"d":"2.76E-41"},{"v":1.93554E-40,"d":"1.94E-40"},"up","yes","Casp1","protein_coding","chr8:2587831-2597383:+","gi|149030162|gb|EDL85233.1|",2144,0,"caspase 1, isoform CRA_b [Rattus norvegicus]","gi|31542340|ref|NM_012762.2|",1275,0,"Rattus norvegicus caspase 1 (Casp1), mRNA","P43527",828,0,"Caspase-1",".",".",".",".","pfam00656","Peptidase_C14","Caspase domain.","GO:0001666|response to hypoxia;GO:0001774|microglial cell activation;GO:0001819|positive regulation of cytokine production;GO:0006508|proteolysis;GO:0006915|apoptotic process;GO:0007494|midgut development;GO:0007520|myoblast fusion;GO:0007613|memory;GO:0009410|response to xenobiotic stimulus;GO:0009617|response to bacterium;GO:0009636|response to toxic substance;GO:0010506|regulation of autophagy;GO:0014070|response to organic cyclic compound;GO:0016485|protein processing;GO:0016540|protein autoprocessing;GO:0030324|lung development;GO:0032496|response to lipopolysaccharide;GO:0032730|positive regulation of interleukin-1 alpha production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0033198|response to ATP;GO:0042981|regulation of apoptotic process;GO:0043065|positive regulation of apoptotic process;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043280|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0046010|positive regulation of circadian sleep/wake cycle, non-REM sleep;GO:0050727|regulation of inflammatory response;GO:0050829|defense response to Gram-negative bacterium;GO:0051882|mitochondrial depolarization;GO:0060081|membrane hyperpolarization;GO:0070269|pyroptosis;GO:0071222|cellular response to lipopolysaccharide;GO:0071260|cellular response to mechanical stimulus;GO:0071310|cellular response to organic substance;GO:0071346|cellular response to interferon-gamma;GO:0097190|apoptotic signaling pathway;GO:0097300|programmed necrotic cell death;GO:1901998|toxin transport;GO:1903265|positive regulation of tumor necrosis factor-mediated signaling pathway;","GO:0005576|extracellular region;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005886|plasma membrane;GO:0032991|protein-containing complex;GO:0043005|neuron projection;GO:0072557|IPAF inflammasome complex;GO:0072558|NLRP1 inflammasome complex;GO:0072559|NLRP3 inflammasome complex;GO:0097169|AIM2 inflammasome complex;GO:0097179|protease inhibitor complex;","GO:0004175|endopeptidase activity;GO:0004197|cysteine-type endopeptidase activity;GO:0005515|protein binding;GO:0008233|peptidase activity;GO:0019900|kinase binding;GO:0042802|identical protein binding;GO:0050700|CARD domain binding;GO:0097110|scaffold protein binding;GO:0097199|cysteine-type endopeptidase activity involved in apoptotic signaling pathway;","K01370","CASP1; caspase 1 [EC:3.4.22.36]"]
["ENSRNOG00000056714",200,16.6053321,30,1.929913146,8.604186226,3.10503875,{"v":3.13564e-41,"d":"3.14E-41"},{"v":2.19361E-40,"d":"2.19E-40"},"up","yes","Sla","protein_coding","chr7:98535368-98584648:-","gi|149066283|gb|EDM16156.1|",1573,0,"src-like adaptor, isoform CRA_b [Rattus norvegicus]","gi|31342521|ref|NM_178097.2|",1624,0,"Rattus norvegicus src-like adaptor (Sla), mRNA","P59622",601,0,"Src-like-adapter",".",".",".",".","pfam00017","SH2","SH2 domain.","GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0009966|regulation of signal transduction;GO:0030154|cell differentiation;GO:0045087|innate immune response;","GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005925|focal adhesion;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0043197|dendritic spine;","GO:0005102|signaling receptor binding;","K23698","SLA; src-like-adapter"]
["ENSRNOG00000008529",784,65.09290185,469,30.17097551,2.157467591,1.109338888,{"v":3.35281e-41,"d":"3.35E-41"},{"v":2.34297e-40,"d":"2.34E-40"},"up","yes","Foxs1","protein_coding","chr3:141397016-141398281:-","gi|58865752|ref|NP_001012091.1|",1625,0,"forkhead box protein S1 [Rattus norvegicus]","gi|86439996|gb|AC129342.5|",1266,0,"Rattus norvegicus BAC CH230-229B21 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q61574",578,0,"Forkhead box protein S1","ECU11g1330",100,{"v":3E-23,"d":"3.00E-23"},"COG5025","pfam00250","Fork_head","Fork head domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001568|blood vessel development;GO:0006357|regulation of transcription by RNA polymerase II;GO:0009653|anatomical structure morphogenesis;GO:0030154|cell differentiation;GO:0040018|positive regulation of multicellular organism growth;GO:0043433|negative regulation of DNA-binding transcription factor activity;GO:0045892|negative regulation of transcription, DNA-templated;GO:0050885|neuromuscular process controlling balance;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003677|DNA binding;","K09412","FKHL18; forkhead-like 18 protein"]
["ENSRNOG00000013231",515,42.75873017,246,15.82528779,2.701924333,1.433987273,{"v":1.91889e-40,"d":"1.92E-40"},{"v":1.32501e-39,"d":"1.33E-39"},"up","yes","Ptafr","protein_coding","chr5:144765976-144795251:+","gi|16758018|ref|NP_445773.1|",1819,0,"platelet-activating factor receptor [Rattus norvegicus]","gi|48675848|ref|NM_053321.2|",3308,0,"Rattus norvegicus platelet-activating factor receptor (Ptafr), mRNA","P46002",705,0,"Platelet-activating factor receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0002693|positive regulation of cellular extravasation;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007567|parturition;GO:0009609|response to symbiotic bacterium;GO:0010863|positive regulation of phospholipase C activity;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0032496|response to lipopolysaccharide;GO:0032755|positive regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032959|inositol trisphosphate biosynthetic process;GO:0035589|G protein-coupled purinergic nucleotide receptor signaling pathway;GO:0043315|positive regulation of neutrophil degranulation;GO:0045056|transcytosis;GO:0045727|positive regulation of translation;GO:0045776|negative regulation of blood pressure;GO:0045987|positive regulation of smooth muscle contraction;GO:0046683|response to organophosphorus;GO:0048015|phosphatidylinositol-mediated signaling;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0060732|positive regulation of inositol phosphate biosynthetic process;GO:0071258|cellular response to gravity;GO:0071320|cellular response to cAMP;GO:0071398|cellular response to fatty acid;GO:0071548|response to dexamethasone;GO:1902943|positive regulation of voltage-gated chloride channel activity;GO:1903039|positive regulation of leukocyte cell-cell adhesion;GO:1903238|positive regulation of leukocyte tethering or rolling;GO:1904058|positive regulation of sensory perception of pain;GO:1904300|positive regulation of transcytosis;GO:1904303|positive regulation of maternal process involved in parturition;GO:1904306|positive regulation of gastro-intestinal system smooth muscle contraction;GO:1904316|response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine;GO:1904317|cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0001530|lipopolysaccharide binding;GO:0001875|lipopolysaccharide receptor activity;GO:0004992|platelet activating factor receptor activity;GO:0005515|protein binding;GO:0005543|phospholipid binding;GO:0045028|G protein-coupled purinergic nucleotide receptor activity;GO:0051019|mitogen-activated protein kinase binding;","K04279","PTAFR; platelet-activating factor receptor"]
["ENSRNOG00000007129",156,12.95215904,11,0.70763482,18.3034507,4.194043756,{"v":2.85897e-40,"d":"2.86E-40"},{"v":1.96354e-39,"d":"1.96E-39"},"up","yes","Cd8b","protein_coding","chr4:103312578-103328553:+","gi|37590779|gb|AAH59127.1|",860,{"v":5E-110,"d":"5.00E-110"},"CD8b molecule [Rattus norvegicus]","gi|37590778|gb|BC059127.1|",673,0,"Rattus norvegicus CD8b molecule, mRNA (cDNA clone MGC:72771 IMAGE:6888323), complete cds","P05541",332,{"v":7e-110,"d":"7.00E-110"},"T-cell surface glycoprotein CD8 beta chain",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0002250|adaptive immune response;GO:0050776|regulation of immune response;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0015026|coreceptor activity;GO:0042288|MHC class I protein binding;","K06459","CD8B; T-cell surface glycoprotein CD8 beta chain"]
["ENSRNOG00000000394",747,62.02091541,442,28.43405368,2.181219608,1.12513503,{"v":3.3163e-40,"d":"3.32E-40"},{"v":2.27519e-39,"d":"2.28E-39"},"up","yes","Srgn","protein_coding","chr20:30442813-30457406:-","gi|149038682|gb|EDL92971.1|",734,{"v":3e-91,"d":"3.00E-91"},"proteoglycan peptide core protein, isoform CRA_b [Rattus norvegicus]","gi|57527906|ref|NM_020074.2|",1283,0,"Rattus norvegicus serglycin (Srgn), mRNA","P04917",251,{"v":9e-80,"d":"9.00E-80"},"Serglycin",".",".",".",".","pfam04360","Serglycin","Serglycin. Serglycin is the most prevalent proteoglycan produced in haemopoietic cells. Serglycin is a proteinase resistant secretory granule proteoglycan.","GO:0001818|negative regulation of cytokine production;GO:0006915|apoptotic process;GO:0008150|biological_process;GO:0016485|protein processing;GO:0030502|negative regulation of bone mineralization;GO:0031214|biomineral tissue development;GO:0033363|secretory granule organization;GO:0033364|mast cell secretory granule organization;GO:0033371|T cell secretory granule organization;GO:0033373|maintenance of protease location in mast cell secretory granule;GO:0033382|maintenance of granzyme B location in T cell secretory granule;GO:0050804|modulation of chemical synaptic transmission;GO:0099175|regulation of postsynapse organization;","GO:0000139|Golgi membrane;GO:0005615|extracellular space;GO:0005794|Golgi apparatus;GO:0030141|secretory granule;GO:0042588|zymogen granule;GO:0042629|mast cell granule;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098978|glutamatergic synapse;GO:0099091|postsynaptic specialization, intracellular component;","GO:0005518|collagen binding;","K06849","PGSG; proteoglycan peptide core protein"]
["ENSRNOG00000059540",202,16.77138543,33,2.12290446,7.900207353,2.98189052,{"v":3.96786e-40,"d":"3.97E-40"},{"v":2.71347E-39,"d":"2.71E-39"},"up","yes","Gcnt3","protein_coding","chr8:70686844-70699562:-","gi|149028853|gb|EDL84194.1|",2443,0,"glucosaminyl (N-acetyl) transferase 3, mucin type, isoform CRA_b [Rattus norvegicus]","gi|672061866|ref|XM_008766220.1|",1802,0,"PREDICTED: Rattus norvegicus glucosaminyl (N-acetyl) transferase 3, mucin type (Gcnt3), transcript variant X2, mRNA","Q8CH87",921,0,"Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3",".",".",".",".","pfam02485","Branch","Core-2/I-Branching enzyme. This is a family of two different beta-1,6-N-acetylglucosaminyltransferase enzymes, I-branching enzyme and core-2 branching enzyme. I-branching enzyme is responsible for the production of the blood group I-antigen during embryonic development. Core-2 branching enzyme forms crucial side-chain branches in O-glycans.","GO:0006486|protein glycosylation;GO:0048729|tissue morphogenesis;GO:0050892|intestinal absorption;GO:0060993|kidney morphogenesis;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0003829|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity;GO:0008109|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity;GO:0008375|acetylglucosaminyltransferase activity;GO:0047225|acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity;","K09662","GCNT3; N-acetylglucosaminyltransferase 3, mucin type [EC:2.4.1.-]"]
["ENSRNOG00000023428",256,21.25482509,63,4.052817606,5.244456367,2.390793233,{"v":4.00055e-40,"d":"4.00E-40"},{"v":2.7329e-39,"d":"2.73E-39"},"up","yes","Pik3r5","protein_coding","chr10:53132603-53199374:+","gi|300794017|ref|NP_001178852.1|",4266,0,"phosphoinositide 3-kinase regulatory subunit 5 [Rattus norvegicus]","gi|672067999|ref|XM_006246770.2|",3176,0,"PREDICTED: Rattus norvegicus phosphoinositide-3-kinase, regulatory subunit 5 (Pik3r5), transcript variant X1, mRNA","Q5SW28",1546,0,"Phosphoinositide 3-kinase regulatory subunit 5",".",".",".",".","pfam10486","PI3K_1B_p101","Phosphoinositide 3-kinase gamma adapter protein p101 subunit. Class I PI3Ks are dual-specific lipid and protein kinases involved in numerous intracellular signaling pathways. Class IB PI3K, p110gamma, is mainly activated by seven-transmembrane G-protein-coupled receptors (GPCRs), through its regulatory subunit p101 and G-protein beta-gamma subunits.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0014065|phosphatidylinositol 3-kinase signaling;GO:0043406|positive regulation of MAP kinase activity;GO:0043551|regulation of phosphatidylinositol 3-kinase activity;GO:0051897|positive regulation of protein kinase B signaling;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005942|phosphatidylinositol 3-kinase complex;GO:0005944|phosphatidylinositol 3-kinase complex, class IB;GO:0016020|membrane;GO:0034451|centriolar satellite;","GO:0031683|G-protein beta/gamma-subunit complex binding;GO:0046935|1-phosphatidylinositol-3-kinase regulator activity;","K21290","PIK3R5_6; phosphoinositide-3-kinase regulatory subunit 5/6"]
["ENSRNOG00000045992",246,20.42455849,58,3.731165415,5.474042616,2.452606666,{"v":9.82561e-40,"d":"9.83E-40"},{"v":6.68362e-39,"d":"6.68E-39"},"up","yes","ENSRNOG00000045992","protein_coding","chrX:27091778-27116549:+","gi|149035901|gb|EDL90568.1|",5084,0,"rCG49623 [Rattus norvegicus]","gi|155369699|ref|NM_001101009.1|",3381,0,"Rattus norvegicus toll-like receptor 8 (Tlr8), mRNA","P58682",1753,0,"Toll-like receptor 8","SPBC19C7.03_1",57,6e-07,"COG4886","pfam01582","TIR","TIR domain. The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.","GO:0001932|regulation of protein phosphorylation;GO:0002224|toll-like receptor signaling pathway;GO:0002755|MyD88-dependent toll-like receptor signaling pathway;GO:0006954|inflammatory response;GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0009615|response to virus;GO:0032695|negative regulation of interleukin-12 production;GO:0032727|positive regulation of interferon-alpha production;GO:0032728|positive regulation of interferon-beta production;GO:0032729|positive regulation of interferon-gamma production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0034158|toll-like receptor 8 signaling pathway;GO:0045087|innate immune response;GO:0045089|positive regulation of innate immune response;GO:0051607|defense response to virus;GO:0071260|cellular response to mechanical stimulus;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0003677|DNA binding;GO:0003725|double-stranded RNA binding;GO:0003727|single-stranded RNA binding;GO:0003953|NAD+ nucleosidase activity;GO:0004888|transmembrane signaling receptor activity;GO:0038187|pattern recognition receptor activity;GO:0042802|identical protein binding;","K10170","TLR8, CD288; toll-like receptor 8"]
["ENSRNOG00000021510",196,16.27322546,31,1.994243584,8.160099195,3.02858669,{"v":1.51358E-39,"d":"1.51E-39"},{"v":1.02521e-38,"d":"1.03E-38"},"up","yes","Tbc1d10c","protein_coding","chr1:201477157-201564920:-","gi|126517485|ref|NP_001075449.1|",2069,0,"carabin [Rattus norvegicus]","gi|126517484|ref|NM_001081980.1|",1707,0,"Rattus norvegicus TBC1 domain family, member 10C (Tbc1d10c), mRNA","Q8C9V1",743,0,"Carabin","YGR100w",125,{"v":3e-29,"d":"3.00E-29"},"COG5210","pfam00566","RabGAP-TBC","Rab-GTPase-TBC domain. Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.","GO:0006886|intracellular protein transport;GO:0042147|retrograde transport, endosome to Golgi;GO:0050869|negative regulation of B cell activation;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0070885|negative regulation of calcineurin-NFAT signaling cascade;GO:0090630|activation of GTPase activity;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0031527|filopodium membrane;","GO:0005096|GTPase activator activity;","K19944","TBC1D10; TBC1 domain family member 10"]
["ENSRNOG00000029662",261,21.6699584,68,4.374469797,4.953733688,2.308516312,{"v":2.78197e-39,"d":"2.78E-39"},{"v":1.87639E-38,"d":"1.88E-38"},"up","yes","Wdfy4","protein_coding","chr16:8221719-8450491:-","gi|564388240|ref|XP_006252821.1|",16294,0,"PREDICTED: WD repeat- and FYVE domain-containing protein 4 isoform X4 [Rattus norvegicus]","gi|672079821|ref|XM_006252759.2|",10075,0,"PREDICTED: Rattus norvegicus WDFY family member 4 (Wdfy4), transcript variant X4, mRNA","Q6ZS81",4984,0,"WD repeat- and FYVE domain-containing protein 4",".",".",".",".","pfam02138","Beach","Beige/BEACH domain.","GO:0019882|antigen processing and presentation;GO:0036037|CD8-positive, alpha-beta T cell activation;GO:0098586|cellular response to virus;",".",".","K24777","WDFY4; WD repeat and FYVE domain-containing protein 4"]
["ENSRNOG00000017804",277,22.99838497,78,5.017774178,4.583383817,2.196413103,{"v":3.08826E-39,"d":"3.09E-39"},{"v":2.08079e-38,"d":"2.08E-38"},"up","yes","Septin1","protein_coding","chr1:181832701-181836566:-","gi|60223053|ref|NP_001012478.1|",1759,0,"septin-1 [Rattus norvegicus]","gi|60223052|ref|NM_001012460.1|",1417,0,"Rattus norvegicus septin 1 (Sept1), mRNA","Q5EB96",682,0,"Septin-1","SPAC821.06",256,{"v":6e-80,"d":"6.00E-80"},"COG5019","pfam00735","Septin","Septin. Members of this family include CDC3, CDC10, CDC11 and CDC12/Septin. Members of this family bind GTP. As regards the septins, these are polypeptides of 30-65kDa with three characteristic GTPase motifs (G-1, G-3 and G-4) that are similar to those of the Ras family. The G-4 motif is strictly conserved with a unique septin consensus of AKAD. Most septins are thought to have at least one coiled-coil region, which in some cases is necessary for intermolecular interactions that allow septins to polymerize to form rod-shaped complexes. In turn, these are arranged into tandem arrays to form filaments. They are multifunctional proteins, with roles in cytokinesis, sporulation, germ cell development, exocytosis and apoptosis.","GO:0007056|spindle assembly involved in female meiosis;GO:0017157|regulation of exocytosis;GO:0034613|cellular protein localization;GO:0051311|meiotic metaphase plate congression;GO:0061640|cytoskeleton-dependent cytokinesis;","GO:0005815|microtubule organizing center;GO:0005940|septin ring;GO:0008021|synaptic vesicle;GO:0015630|microtubule cytoskeleton;GO:0030496|midbody;GO:0031105|septin complex;GO:0032153|cell division site;GO:0072687|meiotic spindle;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0042802|identical protein binding;GO:0060090|molecular adaptor activity;","K13737","SEPT1; septin 1"]
["ENSRNOG00000027502",830,68.91212824,523,33.64481917,2.048224063,1.034373546,{"v":5.12468e-39,"d":"5.12E-39"},{"v":3.44199E-38,"d":"3.44E-38"},"up","yes","Nmi","protein_coding","chr3:36415607-36439498:-","gi|149047828|gb|EDM00444.1|",1652,0,"N-myc (and STAT) interactor, isoform CRA_a [Rattus norvegicus]","gi|77627730|ref|NM_001034148.1|",989,0,"Rattus norvegicus N-myc (and STAT) interactor (Nmi), mRNA","O35309",531,0,"N-myc-interactor",".",".",".",".","pfam07292","NID","Nmi/IFP 35 domain (NID). This family represents a domain of approximately 90 residues that is tandemly repeated within interferon-induced 35 kDa protein (IFP 35) and the homologous N-myc-interactor (Nmi). This domain mediates Nmi-Nmi protein interactions and subcellular localisation.","GO:0002281|macrophage activation involved in immune response;GO:0006355|regulation of transcription, DNA-templated;GO:0006366|transcription by RNA polymerase II;GO:0008150|biological_process;GO:0008285|negative regulation of cell proliferation;GO:0009615|response to virus;GO:0032480|negative regulation of type I interferon production;GO:0032687|negative regulation of interferon-alpha production;GO:0032688|negative regulation of interferon-beta production;GO:0034142|toll-like receptor 4 signaling pathway;GO:0045089|positive regulation of innate immune response;GO:0045824|negative regulation of innate immune response;GO:0050729|positive regulation of inflammatory response;GO:0060333|interferon-gamma-mediated signaling pathway;GO:1901223|negative regulation of NIK/NF-kappaB signaling;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1902524|positive regulation of protein K48-linked ubiquitination;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016020|membrane;","GO:0003674|molecular_function;GO:0003712|transcription coregulator activity;GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000038955",223,18.5149453,47,3.023530595,6.123617644,2.614384204,{"v":9.66726e-39,"d":"9.67E-39"},{"v":6.45235e-38,"d":"6.45E-38"},"up","yes","MGC105567","protein_coding","chr18:53870795-53892024:+","gi|66730425|ref|NP_001019455.1|",2108,0,"uncharacterized protein LOC498873 [Rattus norvegicus]","gi|66730424|ref|NM_001024284.1|",2129,0,"Rattus norvegicus similar to cDNA sequence BC023105 (MGC105567), mRNA","Q9QZ85",429,{"v":8E-136,"d":"8.00E-136"},"Interferon-inducible GTPase 1",".",".",".",".","pfam05049","IIGP","Interferon-inducible GTPase (IIGP). Interferon-inducible GTPase (IIGP) is thought to play a role in in intracellular defence. IIGP is predominantly associated with the Golgi apparatus and also localizes to the endoplasmic reticulum and exerts a distinct role in IFN-induced intracellular membrane trafficking or processing.","GO:0006952|defense response;GO:0035458|cellular response to interferon-beta;","GO:0005789|endoplasmic reticulum membrane;","GO:0003924|GTPase activity;GO:0005525|GTP binding;",".","."]
["ENSRNOG00000021334",183,15.19387888,26,1.672591393,9.084035074,3.183333276,{"v":1.059e-38,"d":"1.06E-38"},{"v":7.05352e-38,"d":"7.05E-38"},"up","yes","Lag3","protein_coding","chr4:157712667-157720404:-","gi|61889117|ref|NP_997678.2|",2198,0,"lymphocyte activation gene 3 protein precursor [Rattus norvegicus]","gi|61889116|ref|NM_212513.2|",1790,0,"Rattus norvegicus lymphocyte activating 3 (Lag3), mRNA","Q5BK54",851,0,"Lymphocyte activation gene 3 protein",".",".",".",".","pfam13927","Ig_3","Immunoglobulin domain. This family contains immunoglobulin-like domains.","GO:0002250|adaptive immune response;GO:0002270|plasmacytoid dendritic cell activation;GO:0007166|cell surface receptor signaling pathway;GO:0032703|negative regulation of interleukin-2 production;GO:0045590|negative regulation of regulatory T cell differentiation;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;GO:0050776|regulation of immune response;GO:0050868|negative regulation of T cell activation;","GO:0005576|extracellular region;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0004888|transmembrane signaling receptor activity;GO:0042289|MHC class II protein binding;","K06565","LAG3, CD223; lymphocyte-activation gene 3 protein"]
["ENSRNOG00000046050",366,30.38775775,140,9.006261346,3.37407017,1.754489978,{"v":1.38337e-38,"d":"1.38E-38"},{"v":9.19479e-38,"d":"9.19E-38"},"up","yes","ENSRNOG00000046050","protein_coding","chr9:1904045-1916187:-","gi|569001579|ref|XP_006524963.1|",3244,0,"PREDICTED: DENN domain-containing protein 1C isoform X3 [Mus musculus]","gi|187281974|ref|NM_001126289.1|",1732,0,"Rattus norvegicus DENN domain containing 1C (Dennd1c), mRNA","Q8CFK6",1245,0,"DENN domain-containing protein 1C",".",".",".",".","pfam02141","DENN","DENN (AEX-3) domain. DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.",".",".",".",".","."]
["ENSRNOG00000007243",148,12.28794576,10,0.643304382,19.10129342,4.255598427,{"v":1.39973e-38,"d":"1.40E-38"},{"v":9.28658e-38,"d":"9.29E-38"},"up","yes","Havcr1","protein_coding","chr10:31119088-31151698:+","gi|564371506|ref|XP_006246225.1|",1275,{"v":8e-169,"d":"8.00E-169"},"PREDICTED: hepatitis A virus cellular receptor 1 homolog isoform X1 [Rattus norvegicus]","gi|672067240|ref|XM_006246163.2|",1961,0,"PREDICTED: Rattus norvegicus hepatitis A virus cellular receptor 1 (Havcr1), transcript variant X1, mRNA","O54947",476,{"v":8e-163,"d":"8.00E-163"},"Hepatitis A virus cellular receptor 1 homolog",".",".",".",".","pfam11465","Receptor_2B4","Natural killer cell receptor 2B4. 2B4 is a transmembrane receptor which is expressed primarily on natural killer cells. It plays a role in activating NK-mediated cytotoxicity through its interaction with CD48 on target cells in a subset of CD8 T cells. The structure of 2B4 consists of an immunoglobulin variable domain fold and contains two beta-sheets. One of the beta-sheets, the six-stranded sheet, contains structural features that may have a role in ligand recognition and receptor function.","GO:0006911|phagocytosis, engulfment;GO:0007584|response to nutrient;GO:0009410|response to xenobiotic stimulus;GO:0009611|response to wounding;GO:0010046|response to mycotoxin;GO:0032496|response to lipopolysaccharide;GO:0033005|positive regulation of mast cell activation;GO:0033574|response to testosterone;GO:0046677|response to antibiotic;GO:0046718|viral entry into host cell;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005903|brush border;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0031514|motile cilium;GO:0045335|phagocytic vesicle;","GO:0001618|virus receptor activity;GO:0001786|phosphatidylserine binding;GO:0003674|molecular_function;","K20413","HAVCR1, CD365; hepatitis A virus cellular receptor 1"]
["ENSRNOG00000059770",289,23.99470489,88,5.66107856,4.238539465,2.08356722,{"v":2.38829e-38,"d":"2.39E-38"},{"v":1.57595e-37,"d":"1.58E-37"},"up","yes","AABR07044383.1","protein_coding","chr20:3403777-3436874:-","gi|672031512|ref|XP_008773126.1|",1327,0,"PREDICTED: class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like isoform X1 [Rattus norvegicus]","gi|672031511|ref|XM_008774904.1|",624,0,"PREDICTED: Rattus norvegicus class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like (LOC103690108), transcript variant X1, mRNA","P16391",468,{"v":1e-163,"d":"1.00E-163"},"RT1 class I histocompatibility antigen, AA alpha chain",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.",".",".",".",".","."]
["ENSRNOG00000011358",642,53.30311606,361,23.22328818,2.295244137,1.198647616,{"v":2.57654e-38,"d":"2.58E-38"},{"v":1.69492e-37,"d":"1.69E-37"},"up","yes","Hipk3","protein_coding","chr3:90800296-90867759:-","gi|149022796|gb|EDL79690.1|",6298,0,"homeodomain interacting protein kinase 3, isoform CRA_a [Rattus norvegicus]","gi|672046435|ref|XM_006234658.2|",4112,0,"PREDICTED: Rattus norvegicus homeodomain interacting protein kinase 3 (Hipk3), transcript variant X1, mRNA","O88850",2428,0,"Homeodomain-interacting protein kinase 3",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006468|protein phosphorylation;GO:0006915|apoptotic process;GO:0009299|mRNA transcription;GO:0018105|peptidyl-serine phosphorylation;GO:0018107|peptidyl-threonine phosphorylation;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0043066|negative regulation of apoptotic process;GO:0043508|negative regulation of JUN kinase activity;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016604|nuclear body;GO:0016605|PML body;","GO:0003677|DNA binding;GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0005524|ATP binding;","K08826","HIPK; homeodomain interacting protein kinase [EC:2.7.11.1]"]
["ENSRNOG00000020989",571,47.40822316,302,19.42779233,2.440226988,1.287015352,{"v":4.11282e-38,"d":"4.11E-38"},{"v":2.69721e-37,"d":"2.70E-37"},"up","yes","Tm7sf2","protein_coding","chr1:203355931-203360270:-","gi|61556857|ref|NP_001013089.1|",1732,0,"delta(14)-sterol reductase [Rattus norvegicus]","gi|61556856|ref|NM_001013071.1|",1467,0,"Rattus norvegicus transmembrane 7 superfamily member 2 (Tm7sf2), mRNA","Q71KT5",634,0,"Delta(14)-sterol reductase",".",".",".",".","pfam01222","ERG4_ERG24","Ergosterol biosynthesis ERG4/ERG24 family.","GO:0006695|cholesterol biosynthetic process;GO:0016126|sterol biosynthetic process;","GO:0005637|nuclear inner membrane;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0030176|integral component of endoplasmic reticulum membrane;GO:0031090|organelle membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0043235|receptor complex;","GO:0016627|oxidoreductase activity, acting on the CH-CH group of donors;GO:0050613|delta14-sterol reductase activity;","K00222","TM7SF2, ERG24; Delta14-sterol reductase [EC:1.3.1.70]"]
["ENSRNOG00000016248",759,63.01723534,466,29.97798419,2.102117171,1.071843087,{"v":7.19294e-38,"d":"7.19E-38"},{"v":4.6931e-37,"d":"4.69E-37"},"up","yes","Sox18","protein_coding","chr3:168785490-168787290:-","gi|67078462|ref|NP_001019952.1|",1374,0,"transcription factor SOX-18 [Rattus norvegicus]","gi|67078461|ref|NM_001024781.1|",1617,0,"Rattus norvegicus SRY box 18 (Sox18), mRNA","P43680",516,{"v":4e-179,"d":"4.00E-179"},"Transcription factor SOX-18",".",".",".",".","pfam12067","Sox_C_TAD","Sox C-terminal transactivation domain. This domain is found at the C-terminus of the Sox family of transcription factors. It is found associated with pfam00505. It binds to the Armadillo repeats (pfam00514) in Catenin beta-1 (CTNNB1), which is involved in transcriptional regulation. It functions as a transactivating domain (TAD).","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001525|angiogenesis;GO:0001568|blood vessel development;GO:0001570|vasculogenesis;GO:0001701|in utero embryonic development;GO:0001942|hair follicle development;GO:0001944|vasculature development;GO:0001945|lymph vessel development;GO:0001946|lymphangiogenesis;GO:0006355|regulation of transcription, DNA-templated;GO:0007507|heart development;GO:0008150|biological_process;GO:0009653|anatomical structure morphogenesis;GO:0022405|hair cycle process;GO:0030154|cell differentiation;GO:0035050|embryonic heart tube development;GO:0043534|blood vessel endothelial cell migration;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048469|cell maturation;GO:0048866|stem cell fate specification;GO:0060214|endocardium formation;GO:0060836|lymphatic endothelial cell differentiation;GO:0060956|endocardial cell differentiation;GO:0061028|establishment of endothelial barrier;GO:0072091|regulation of stem cell proliferation;","GO:0000785|chromatin;GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09270","SOX7S; transcription factor SOX7/8/10/18 (SOX group E/F)"]
["ENSRNOG00000007214",512,42.50965019,255,16.40426174,2.59137844,1.373719719,{"v":8.51672e-38,"d":"8.52E-38"},{"v":5.55115e-37,"d":"5.55E-37"},"up","yes","Oma1","protein_coding","chr5:118083728-118136980:+","gi|157820983|ref|NP_001100139.1|",2443,0,"metalloendopeptidase OMA1, mitochondrial [Rattus norvegicus]","gi|672053125|ref|XM_006238476.2|",1031,0,"PREDICTED: Rattus norvegicus OMA1 zinc metallopeptidase (Oma1), transcript variant X2, mRNA","D3ZS74",945,0,"Metalloendopeptidase OMA1, mitochondrial","SPAP14E8.04",130,{"v":3E-32,"d":"3.00E-32"},"COG0501","pfam01435","Peptidase_M48","Peptidase family M48.","GO:0002024|diet induced thermogenesis;GO:0006006|glucose metabolic process;GO:0006515|protein quality control for misfolded or incompletely synthesized proteins;GO:0006629|lipid metabolic process;GO:0007005|mitochondrion organization;GO:0010637|negative regulation of mitochondrial fusion;GO:0016540|protein autoprocessing;GO:0031638|zymogen activation;GO:0033108|mitochondrial respiratory chain complex assembly;GO:0034982|mitochondrial protein processing;GO:0042407|cristae formation;GO:0043065|positive regulation of apoptotic process;GO:0097009|energy homeostasis;GO:0120162|positive regulation of cold-induced thermogenesis;GO:1903850|regulation of cristae formation;","GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0016021|integral component of membrane;GO:0031966|mitochondrial membrane;","GO:0004222|metalloendopeptidase activity;GO:0008289|lipid binding;GO:0046872|metal ion binding;","K23010","OMA1; metalloendopeptidase OMA1, mitochondrial [EC:3.4.24.-]"]
["ENSRNOG00000027350",759,63.01723534,468,30.10664507,2.093133765,1.065664512,{"v":1.56985e-37,"d":"1.57E-37"},{"v":1.017E-36,"d":"1.02E-36"},"up","yes","Tns4","protein_coding","chr10:84021966-84041346:-","gi|149054153|gb|EDM05970.1|",3378,0,"tensin 4 [Rattus norvegicus]","gi|67846031|ref|NM_001024881.1|",2467,0,"Rattus norvegicus tensin 4 (Tns4), mRNA","Q4V8I3",1304,0,"Tensin-4",".",".",".",".","pfam08416","PTB","Phosphotyrosine-binding domain. The phosphotyrosine-binding domain (PTB, also phosphotyrosine-interaction or PI domain) in the protein tensin tends to be found at the C-terminus. Tensin is a multi-domain protein that binds to actin filaments and functions as a focal-adhesion molecule (focal adhesions are regions of plasma membrane through which cells attach to the extracellular matrix). Human tensin has actin-binding sites, an SH2 (pfam00017) domain and a region similar to the tumor suppressor PTEN. The PTB domain interacts with the cytoplasmic tails of beta integrin by binding to an NPXY motif.","GO:0006915|apoptotic process;GO:0008104|protein localization;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005925|focal adhesion;","GO:0003779|actin binding;","K18080","TNS; tensin"]
["ENSRNOG00000042771",342,28.3951179,127,8.169965649,3.475549239,1.797240984,{"v":2.45877e-37,"d":"2.46E-37"},{"v":1.58804e-36,"d":"1.59E-36"},"up","yes","Apol3","protein_coding","chr7:109288725-109297723:+","gi|61557187|ref|NP_001013193.1|",1434,0,"apolipoprotein L, 3 [Rattus norvegicus]","gi|475505004|ref|NM_001277359.1|",1298,0,"Rattus norvegicus apolipoprotein L, 3 (Apol3), transcript variant 1, mRNA","O95236",185,{"v":8e-51,"d":"8.00E-51"},"Apolipoprotein L3",".",".",".",".","pfam05461","ApoL","Apolipoprotein L. Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.","GO:0006869|lipid transport;GO:0042157|lipoprotein metabolic process;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;","GO:0005576|extracellular region;","GO:0008289|lipid binding;","K14480","APOL; apolipoprotein L"]
["ENSRNOG00000007310",160,13.28426568,18,1.157947887,11.4722483,3.52007625,{"v":6.68882e-37,"d":"6.69E-37"},{"v":4.27263E-36,"d":"4.27E-36"},"up","yes","Klrb1a","protein_coding","chr4:161890577-161961675:-","gi|148539924|ref|NP_775414.2|",1057,{"v":5e-141,"d":"5.00E-141"},"killer cell lectin-like receptor subfamily B member 1B [Rattus norvegicus]","gi|1354767|gb|U56936.1|RNU56936",1089,0,"Rattus norvegicus NK lymphocyte receptor (NKR-P1B) mRNA, complete cds","A4KWA1",411,{"v":2e-142,"d":"2.00E-142"},"Killer cell lectin-like receptor subfamily B member 1B allele A",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type",".","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0030246|carbohydrate binding;","K06543","KLRB, CD161; killer cell lectin-like receptor subfamily B"]
["ENSRNOG00000052880",176,14.61269225,26,1.672591393,8.736558322,3.127065057,{"v":1.02291e-36,"d":"1.02E-36"},{"v":6.4951e-36,"d":"6.50E-36"},"up","yes","Prph","protein_coding","chr7:130218357-130222136:+","gi|672059812|ref|XP_008763891.1|",1847,0,"PREDICTED: peripherin isoform X2 [Rattus norvegicus]","gi|672059811|ref|XM_008765669.1|",1849,0,"PREDICTED: Rattus norvegicus peripherin (Prph), transcript variant X2, mRNA","P21807",656,0,"Peripherin",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0045104|intermediate filament cytoskeleton organization;","GO:0001750|photoreceptor outer segment;GO:0005882|intermediate filament;GO:0005883|neurofilament;GO:0030424|axon;GO:0042622|photoreceptor outer segment membrane;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0043204|perikaryon;GO:0044299|C-fiber;GO:0045098|type III intermediate filament;","GO:0005198|structural molecule activity;GO:0005515|protein binding;GO:0044877|protein-containing complex binding;","K07607","PRPH; peripherin"]
["ENSRNOG00000007062",566,46.99308986,305,19.62078365,2.39506692,1.260065967,{"v":1.2685e-36,"d":"1.27E-36"},{"v":8.03856e-36,"d":"8.04E-36"},"up","yes","Rin3","protein_coding","chr6:121431339-121540957:+","gi|564357029|ref|XP_006240535.1|",4037,0,"PREDICTED: ras and Rab interactor 3 isoform X2 [Rattus norvegicus]","gi|672056635|ref|XM_008764804.1|",4567,0,"PREDICTED: Rattus norvegicus Ras and Rab interactor 3 (Rin3), transcript variant X3, mRNA","P59729",1391,0,"Ras and Rab interactor 3",".",".",".",".","pfam02204","VPS9","Vacuolar sorting protein 9 (VPS9) domain. This domain acts as a GDP-GTP exchange factor (GEF). It activates Rab GTPases by stimulating the release of GDP and allowing GTP to bind.","GO:0002091|negative regulation of receptor internalization;GO:0007165|signal transduction;GO:0016192|vesicle-mediated transport;GO:0050790|regulation of catalytic activity;GO:0060755|negative regulation of mast cell chemotaxis;GO:0097494|regulation of vesicle size;","GO:0005737|cytoplasm;GO:0005769|early endosome;GO:0030139|endocytic vesicle;GO:0030424|axon;GO:0030425|dendrite;GO:0031410|cytoplasmic vesicle;GO:0031982|vesicle;GO:0043025|neuronal cell body;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0031267|small GTPase binding;","K23687","RIN2_3; Ras and Rab interactor 2/3"]
["ENSRNOG00000016995",159,13.20123902,18,1.157947887,11.40054675,3.51103111,{"v":1.30469e-36,"d":"1.30E-36"},{"v":8.25971e-36,"d":"8.26E-36"},"up","yes","Zap70","protein_coding","chr9:38989750-39011700:+","gi|564367964|ref|XP_006244823.1|",3224,0,"PREDICTED: tyrosine-protein kinase ZAP-70 isoform X2 [Rattus norvegicus]","gi|672064817|ref|XM_006244761.2|",2113,0,"PREDICTED: Rattus norvegicus zeta-chain (TCR) associated protein kinase 70 (Zap70), transcript variant X1, mRNA","P43404",1216,0,"Tyrosine-protein kinase ZAP-70",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0002250|adaptive immune response;GO:0006468|protein phosphorylation;GO:0006955|immune response;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0008150|biological_process;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0030154|cell differentiation;GO:0035556|intracellular signal transduction;GO:0043366|beta selection;GO:0045059|positive thymic T cell selection;GO:0045060|negative thymic T cell selection;GO:0045061|thymic T cell selection;GO:0045087|innate immune response;GO:0045582|positive regulation of T cell differentiation;GO:0046638|positive regulation of alpha-beta T cell differentiation;GO:0046641|positive regulation of alpha-beta T cell proliferation;GO:0046777|protein autophosphorylation;GO:0050850|positive regulation of calcium-mediated signaling;GO:0050852|T cell receptor signaling pathway;","GO:0001772|immunological synapse;GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0016020|membrane;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0042101|T cell receptor complex;GO:0045121|membrane raft;","GO:0001784|phosphotyrosine residue binding;GO:0003674|molecular_function;GO:0004672|protein kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0005102|signaling receptor binding;GO:0005524|ATP binding;","K07360","ZAP70; tyrosine-protein kinase ZAP-70 [EC:2.7.10.2]"]
["ENSRNOG00000032396",150,12.45399908,14,0.900626135,13.82815644,3.789536925,{"v":1.54722E-36,"d":"1.55E-36"},{"v":9.78544e-36,"d":"9.79E-36"},"up","yes","RGD1559575","protein_coding","chr10:33252134-33276225:-","gi|109488030|ref|XP_220362.3|",4236,0,"PREDICTED: uncharacterized protein RGD1559575 [Rattus norvegicus]","gi|672024715|ref|XM_001070154.4|",2936,0,"PREDICTED: Rattus norvegicus similar to novel protein (RGD1559575), mRNA","Q3T9E4",521,{"v":1E-173,"d":"1.00E-173"},"T-cell-specific guanine nucleotide triphosphate-binding protein 2",".",".",".",".","pfam05049","IIGP","Interferon-inducible GTPase (IIGP). Interferon-inducible GTPase (IIGP) is thought to play a role in in intracellular defence. IIGP is predominantly associated with the Golgi apparatus and also localizes to the endoplasmic reticulum and exerts a distinct role in IFN-induced intracellular membrane trafficking or processing.","GO:0006952|defense response;GO:0035458|cellular response to interferon-beta;","GO:0005789|endoplasmic reticulum membrane;","GO:0003924|GTPase activity;GO:0005525|GTP binding;",".","."]
["ENSRNOG00000001976",138,11.45767915,1,0.064330438,178.1066549,7.476597613,{"v":1.83857e-36,"d":"1.84E-36"},{"v":1.16051E-35,"d":"1.16E-35"},"up","yes","Tmprss2","protein_coding","chr11:36934306-36973715:-","gi|149060257|gb|EDM10971.1|",1941,0,"transmembrane protease, serine 2, isoform CRA_b [Rattus norvegicus]","gi|829708433|ref|NM_130424.3|",1831,0,"Rattus norvegicus transmembrane protease, serine 2 (Tmprss2), mRNA","Q9JIQ8",680,0,"Transmembrane protease serine 2","mlr3307",70.5,{"v":7e-12,"d":"7.00E-12"},"COG5640","pfam15494","SRCR_2","Scavenger receptor cysteine-rich domain. SRCR_2 is a scavenger receptor cysteine-rich domain family found largely on vertebrate sequences up-stream of the trypsin-like transmembrane serine protease, Spinesin.","GO:0006508|proteolysis;GO:0006897|endocytosis;GO:0016540|protein autoprocessing;GO:0046598|positive regulation of viral entry into host cell;","GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0004252|serine-type endopeptidase activity;GO:0005044|scavenger receptor activity;","K09633","TMPRSS2; transmembrane protease serine 2 [EC:3.4.21.-]"]
["ENSRNOG00000023005",136,11.29162583,8,0.514643505,21.94067488,4.455535997,{"v":2.30652e-36,"d":"2.31E-36"},{"v":1.45445e-35,"d":"1.45E-35"},"up","yes","ENSRNOG00000023005","protein_coding","chrX:74312661-74316635:+","gi|157822063|ref|NP_001102909.1|",1613,0,"uncharacterized protein LOC681325 [Rattus norvegicus]","gi|298915231|emb|FQ226125.1|",2741,0,"Rattus norvegicus TL0AEA37YM22 mRNA sequence",".",".",".",".",".",".",".",".","pfam15133","DUF4569","Domain of unknown function (DUF4569). This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. This family includes human protein CXorf21.","GO:0034121|regulation of toll-like receptor signaling pathway;GO:0035751|regulation of lysosomal lumen pH;",".",".",".","."]
["ENSRNOG00000010725",422,35.03725074,190,12.22278326,2.866552569,1.519316737,{"v":2.65996E-36,"d":"2.66E-36"},{"v":1.67567e-35,"d":"1.68E-35"},"up","yes","Cpa1","protein_coding","chr4:59257417-59263544:+","gi|333033815|ref|NP_058694.2|",2260,0,"carboxypeptidase A1 preproprotein [Rattus norvegicus]","gi|333033814|ref|NM_016998.3|",1633,0,"Rattus norvegicus carboxypeptidase A1 (Cpa1), mRNA","P00731",875,0,"Carboxypeptidase A1","YHR132c",176,{"v":4e-48,"d":"4.00E-48"},"COG2866","pfam00246","Peptidase_M14","Zinc carboxypeptidase.","GO:0006508|proteolysis;GO:0006691|leukotriene metabolic process;GO:0051603|proteolysis involved in cellular protein catabolic process;","GO:0005615|extracellular space;","GO:0004181|metallocarboxypeptidase activity;GO:0008238|exopeptidase activity;GO:0008270|zinc ion binding;","K08779","CPA1; carboxypeptidase A1 [EC:3.4.17.1]"]
["ENSRNOG00000020884",144,11.95583912,12,0.771965258,15.48753521,3.953035657,{"v":4.36083e-36,"d":"4.36E-36"},{"v":2.73101e-35,"d":"2.73E-35"},"up","yes","Cd6","protein_coding","chr1:207442877-207481634:-","gi|58477106|gb|AAH89767.1|",2923,0,"Cd6 protein [Rattus norvegicus]","gi|58477105|gb|BC089767.1|",3426,0,"Rattus norvegicus Cd6 molecule, mRNA (cDNA clone MGC:108551 IMAGE:7383438), complete cds","Q61003",933,0,"T-cell differentiation antigen CD6",".",".",".",".","pfam00530","SRCR","Scavenger receptor cysteine-rich domain. These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.","GO:0001771|immunological synapse formation;GO:0001934|positive regulation of protein phosphorylation;GO:0002438|acute inflammatory response to antigenic stimulus;GO:0006897|endocytosis;GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0032496|response to lipopolysaccharide;GO:0042102|positive regulation of T cell proliferation;GO:1900017|positive regulation of cytokine production involved in inflammatory response;","GO:0001772|immunological synapse;GO:0009897|external side of plasma membrane;GO:0031226|intrinsic component of plasma membrane;GO:0044214|spanning component of plasma membrane;","GO:0001530|lipopolysaccharide binding;GO:0005044|scavenger receptor activity;GO:0005515|protein binding;GO:0019901|protein kinase binding;GO:0042802|identical protein binding;GO:0070891|lipoteichoic acid binding;","K06456","CD6; T-cell surface glycoprotein CD6"]
["ENSRNOG00000012611",333,27.64787795,125,8.041304773,3.438232816,1.781667239,{"v":5.52264E-36,"d":"5.52E-36"},{"v":3.4451e-35,"d":"3.45E-35"},"up","yes","Lpxn","protein_coding","chr1:209929202-209963084:+","gi|57526976|ref|NP_001009649.1|",1916,0,"leupaxin [Rattus norvegicus]","gi|57526975|ref|NM_001009649.1|",1617,0,"Rattus norvegicus leupaxin (Lpxn), mRNA","Q99N69",695,0,"Leupaxin",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.","GO:0006355|regulation of transcription, DNA-templated;GO:0007162|negative regulation of cell adhesion;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0008150|biological_process;GO:0033628|regulation of cell adhesion mediated by integrin;GO:0034446|substrate adhesion-dependent cell spreading;GO:0043542|endothelial cell migration;GO:0050859|negative regulation of B cell receptor signaling pathway;","GO:0002102|podosome;GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005925|focal adhesion;GO:0016607|nuclear speck;GO:0042995|cell projection;GO:0048471|perinuclear region of cytoplasm;","GO:0003674|molecular_function;GO:0003712|transcription coregulator activity;GO:0046872|metal ion binding;","K24314","LPXN; leupaxin"]
["ENSRNOG00000015945",154,12.78610572,17,1.093617449,11.6915707,3.547396856,{"v":8.73565e-36,"d":"8.74E-36"},{"v":5.42297e-35,"d":"5.42E-35"},"up","yes","Cd3g","protein_coding","chr8:45281204-45287147:-","gi|564363364|ref|XP_006242994.1|",782,{"v":9E-103,"d":"9.00E-103"},"PREDICTED: T-cell surface glycoprotein CD3 gamma chain isoform X1 [Rattus norvegicus]","gi|672061630|ref|XM_006242932.2|",492,0,"PREDICTED: Rattus norvegicus CD3 molecule, gamma (Cd3g), transcript variant X1, mRNA","Q64159",303,{"v":3E-103,"d":"3.00E-103"},"T-cell surface glycoprotein CD3 gamma chain",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0002250|adaptive immune response;GO:0007163|establishment or maintenance of cell polarity;GO:0007166|cell surface receptor signaling pathway;GO:0008150|biological_process;GO:0015031|protein transport;GO:0045059|positive thymic T cell selection;GO:0070228|regulation of lymphocyte apoptotic process;","GO:0005575|cellular_component;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0042105|alpha-beta T cell receptor complex;","GO:0003674|molecular_function;GO:0004888|transmembrane signaling receptor activity;GO:0042802|identical protein binding;GO:0046982|protein heterodimerization activity;","K06452","CD3G; T-cell surface glycoprotein CD3 gamma chain"]
["ENSRNOG00000007539",210,17.43559871,46,2.959200157,5.89199709,2.558756718,{"v":9.14958e-36,"d":"9.15E-36"},{"v":5.67443e-35,"d":"5.67E-35"},"up","yes","Rsad2","protein_coding","chr6:43047658-43059699:-","gi|149051031|gb|EDM03204.1|",1839,0,"rCG62278 [Rattus norvegicus]","gi|20302056|ref|NM_138881.1|",2366,0,"Rattus norvegicus radical S-adenosyl methionine domain containing 2 (Rsad2), mRNA","O70600",707,0,"Radical S-adenosyl methionine domain-containing protein 2","BH2526",56.2,2e-07,"COG2896","pfam04055","Radical_SAM","Radical SAM superfamily. Radical SAM proteins catalyse diverse reactions, including unusual methylations, isomerization, sulphur insertion, ring formation, anaerobic oxidation and protein radical formation.","GO:0001503|ossification;GO:0009615|response to virus;GO:0030278|regulation of ossification;GO:0034157|positive regulation of toll-like receptor 7 signaling pathway;GO:0034165|positive regulation of toll-like receptor 9 signaling pathway;GO:0035710|CD4-positive, alpha-beta T cell activation;GO:0043367|CD4-positive, alpha-beta T cell differentiation;GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0050709|negative regulation of protein secretion;GO:0050778|positive regulation of immune response;GO:0051607|defense response to virus;GO:2000553|positive regulation of T-helper 2 cell cytokine production;","GO:0001650|fibrillar center;GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0005743|mitochondrial inner membrane;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005794|Golgi apparatus;GO:0005811|lipid droplet;","GO:0003674|molecular_function;GO:0003824|catalytic activity;GO:0016829|lyase activity;GO:0043621|protein self-association;GO:0046872|metal ion binding;GO:0051539|4 iron, 4 sulfur cluster binding;","K15045","RSAD2; radical S-adenosyl methionine domain-containing protein 2"]
["ENSRNOG00000015668",193,16.02414548,37,2.380226213,6.732194358,2.751076828,{"v":1.47746e-35,"d":"1.48E-35"},{"v":9.12754e-35,"d":"9.13E-35"},"up","yes","Ccl19","protein_coding","chr5:56963364-56965308:-","gi|755507561|ref|XP_006538477.2|",583,{"v":1e-72,"d":"1.00E-72"},"PREDICTED: C-C motif chemokine 19-like, partial [Mus musculus]","gi|157821836|ref|NM_001108661.1|",715,0,"Rattus norvegicus chemokine (C-C motif) ligand 19 (Ccl19), mRNA","O70460",177,{"v":9e-55,"d":"9.00E-55"},"C-C motif chemokine 19",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0001768|establishment of T cell polarity;GO:0001771|immunological synapse formation;GO:0002407|dendritic cell chemotaxis;GO:0002408|myeloid dendritic cell chemotaxis;GO:0002548|monocyte chemotaxis;GO:0002606|positive regulation of dendritic cell antigen processing and presentation;GO:0006954|inflammatory response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0010560|positive regulation of glycoprotein biosynthetic process;GO:0030593|neutrophil chemotaxis;GO:0031295|T cell costimulation;GO:0031640|killing of cells of other organism;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032735|positive regulation of interleukin-12 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0034695|response to prostaglandin E;GO:0042102|positive regulation of T cell proliferation;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043507|positive regulation of JUN kinase activity;GO:0043547|positive regulation of GTPase activity;GO:0043552|positive regulation of phosphatidylinositol 3-kinase activity;GO:0045627|positive regulation of T-helper 1 cell differentiation;GO:0045807|positive regulation of endocytosis;GO:0045860|positive regulation of protein kinase activity;GO:0046330|positive regulation of JNK cascade;GO:0048247|lymphocyte chemotaxis;GO:0048260|positive regulation of receptor-mediated endocytosis;GO:0048469|cell maturation;GO:0050921|positive regulation of chemotaxis;GO:0051209|release of sequestered calcium ion into cytosol;GO:0051897|positive regulation of protein kinase B signaling;GO:0060491|regulation of cell projection assembly;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098|chemokine-mediated signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071731|response to nitric oxide;GO:0090023|positive regulation of neutrophil chemotaxis;GO:0097029|mature conventional dendritic cell differentiation;GO:0098586|cellular response to virus;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:2000147|positive regulation of cell motility;GO:2000549|positive regulation of dendritic cell dendrite assembly;GO:2000669|negative regulation of dendritic cell apoptotic process;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0009897|external side of plasma membrane;","GO:0003674|molecular_function;GO:0008009|chemokine activity;GO:0031732|CCR7 chemokine receptor binding;GO:0031735|CCR10 chemokine receptor binding;GO:0042379|chemokine receptor binding;GO:0048020|CCR chemokine receptor binding;","K05512","CCL19, ELC; C-C motif chemokine 19"]
["ENSRNOG00000054957",575,47.7403298,319,20.52140978,2.326366966,1.218078688,{"v":2.43552e-35,"d":"2.44E-35"},{"v":1.49596E-34,"d":"1.50E-34"},"up","yes","Sfrp4","protein_coding","chr17:45234097-45330736:-","gi|149029250|gb|EDL84517.1|",1450,0,"secreted frizzled-related protein 4, isoform CRA_b [Rattus norvegicus]","gi|14279148|gb|AF220608.1|AF220608",2876,0,"Rattus norvegicus frizzled related protein (Frp) mRNA, complete cds","Q9JLS4",555,0,"Secreted frizzled-related protein 4",".",".",".",".","pfam01392","Fz","Fz domain. Also known as the CRD (cysteine rich domain), the C6 box in MuSK receptor. This domain of unknown function has been independently identified by several groups. The domain contains 10 conserved cysteines.","GO:0002092|positive regulation of receptor internalization;GO:0007565|female pregnancy;GO:0008285|negative regulation of cell proliferation;GO:0010628|positive regulation of gene expression;GO:0016055|Wnt signaling pathway;GO:0030154|cell differentiation;GO:0030510|regulation of BMP signaling pathway;GO:0032355|response to estradiol;GO:0035567|non-canonical Wnt signaling pathway;GO:0043065|positive regulation of apoptotic process;GO:0043433|negative regulation of DNA-binding transcription factor activity;GO:0043434|response to peptide hormone;GO:0045606|positive regulation of epidermal cell differentiation;GO:0046329|negative regulation of JNK cascade;GO:0046697|decidualization;GO:0051384|response to glucocorticoid;GO:0055062|phosphate ion homeostasis;GO:0060056|mammary gland involution;GO:0060070|canonical Wnt signaling pathway;GO:0060349|bone morphogenesis;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:1902174|positive regulation of keratinocyte apoptotic process;GO:2000051|negative regulation of non-canonical Wnt signaling pathway;GO:2000119|negative regulation of sodium-dependent phosphate transport;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0009986|cell surface;","GO:0017147|Wnt-protein binding;","K02185","SFRP4; secreted frizzled-related protein 4"]
["ENSRNOG00000046683",341,28.31209124,133,8.555948279,3.309053575,1.72641865,{"v":2.6585E-35,"d":"2.66E-35"},{"v":1.62979e-34,"d":"1.63E-34"},"up","yes","Lilrb3","protein_coding","chr1:69928945-69939048:-","gi|392337441|ref|XP_001070618.3|",4166,0,"PREDICTED: leukocyte immunoglobulin-like receptor subfamily B member 3 isoform X2 [Rattus norvegicus]","gi|672035326|ref|XM_006228230.2|",2925,0,"PREDICTED: Rattus norvegicus similar to PIRB1 (RGD1566307), transcript variant X9, mRNA","P97484",593,0,"Leukocyte immunoglobulin-like receptor subfamily B member 3",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.",".","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;",".","K06512","LILR, CD85; leukocyte immunoglobulin-like receptor"]
["ENSRNOG00000014333",643,53.38614272,378,24.31690563,2.195433232,1.134505659,{"v":2.71673e-35,"d":"2.72E-35"},{"v":1.66389e-34,"d":"1.66E-34"},"up","yes","Vcam1","protein_coding","chr2:204038114-204057958:-","gi|6981700|ref|NP_037021.1|",3705,0,"vascular cell adhesion protein 1 precursor [Rattus norvegicus]","gi|58476811|gb|BC089812.1|",2890,0,"Rattus norvegicus vascular cell adhesion molecule 1, mRNA (cDNA clone MGC:108734 IMAGE:7364929), complete cds","P29534",1431,0,"Vascular cell adhesion protein 1",".",".",".",".","pfam05790","C2-set","Immunoglobulin C2-set domain.","GO:0001666|response to hypoxia;GO:0002526|acute inflammatory response;GO:0002544|chronic inflammatory response;GO:0007155|cell adhesion;GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007159|leukocyte cell-cell adhesion;GO:0007160|cell-matrix adhesion;GO:0007507|heart development;GO:0007568|aging;GO:0007584|response to nutrient;GO:0009308|amine metabolic process;GO:0010043|response to zinc ion;GO:0010212|response to ionizing radiation;GO:0022614|membrane to membrane docking;GO:0032496|response to lipopolysaccharide;GO:0034113|heterotypic cell-cell adhesion;GO:0035094|response to nicotine;GO:0035584|calcium-mediated signaling using intracellular calcium source;GO:0035924|cellular response to vascular endothelial growth factor stimulus;GO:0042102|positive regulation of T cell proliferation;GO:0045471|response to ethanol;GO:0050901|leukocyte tethering or rolling;GO:0060326|cell chemotaxis;GO:0060384|innervation;GO:0060669|embryonic placenta morphogenesis;GO:0060710|chorio-allantoic fusion;GO:0060945|cardiac neuron differentiation;GO:0071333|cellular response to glucose stimulus;GO:0071356|cellular response to tumor necrosis factor;GO:0098609|cell-cell adhesion;GO:0140039|cell-cell adhesion in response to extracellular stimulus;GO:1904646|cellular response to amyloid-beta;","GO:0002102|podosome;GO:0005615|extracellular space;GO:0005769|early endosome;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005887|integral component of plasma membrane;GO:0005902|microvillus;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0030175|filopodium;GO:0042383|sarcolemma;GO:0045177|apical part of cell;GO:0071065|alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex;GO:0071944|cell periphery;","GO:0005178|integrin binding;GO:0008131|primary amine oxidase activity;GO:0050839|cell adhesion molecule binding;","K06527","VCAM1, CD106; vascular cell adhesion molecule 1"]
["ENSRNOG00000037757",130,10.79346587,7,0.450313067,23.96880449,4.583086047,{"v":3.04587E-35,"d":"3.05E-35"},{"v":1.8637E-34,"d":"1.86E-34"},"up","yes","Calhm6","protein_coding","chr20:26095592-26097278:-","gi|68163374|ref|NP_001020147.1|",1387,0,"protein FAM26F [Rattus norvegicus]","gi|298890069|emb|FQ230614.1|",1079,0,"Rattus norvegicus TL0AEA8YL17 mRNA sequence","Q561R8",538,0,"Calcium homeostasis modulator protein 6",".",".",".",".","pfam14798","Ca_hom_mod","Calcium homeostasis modulator. This family of proteins control cytosolic calcium concentration. They are transmembrane proteins which may be pore-forming ion channels.","GO:0098655|cation transmembrane transport;","GO:0005887|integral component of plasma membrane;","GO:0005261|cation channel activity;",".","."]
["ENSRNOG00000009291",154,12.78610572,18,1.157947887,11.04203899,3.464934695,{"v":3.6698e-35,"d":"3.67E-35"},{"v":2.24117e-34,"d":"2.24E-34"},"up","yes","Dnase1l3","protein_coding","chr15:16922335-16948317:+","gi|16758784|ref|NP_446359.1|",1343,{"v":2E-180,"d":"2.00E-180"},"deoxyribonuclease gamma precursor [Rattus norvegicus]","gi|56789879|gb|BC088122.1|",1017,0,"Rattus norvegicus deoxyribonuclease 1-like 3, mRNA (cDNA clone MGC:108624 IMAGE:7325326), complete cds","O89107",521,0,"Deoxyribonuclease gamma",".",".",".",".","pfam03372","Exo_endo_phos","Endonuclease/Exonuclease/phosphatase family. This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins EC:4.2.99.18, DNase I proteins EC:3.1.21.1, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56, Sphingomyelinase EC:3.1.4.12 and Nocturnin.","GO:0000737|DNA catabolic process, endonucleolytic;GO:0002283|neutrophil activation involved in immune response;GO:0002673|regulation of acute inflammatory response;GO:0006308|DNA catabolic process;GO:0006309|apoptotic DNA fragmentation;GO:0010623|programmed cell death involved in cell development;GO:0070948|regulation of neutrophil mediated cytotoxicity;","GO:0005576|extracellular region;GO:0005634|nucleus;GO:0005783|endoplasmic reticulum;","GO:0003677|DNA binding;GO:0004519|endonuclease activity;GO:0004520|endodeoxyribonuclease activity;GO:0004530|deoxyribonuclease I activity;","K11995","DNASE1L; deoxyribonuclease-1-like protein [EC:3.1.21.-]"]
["ENSRNOG00000011947",188,15.60901218,36,2.315895775,6.739945877,2.752737006,{"v":1.06094E-34,"d":"1.06E-34"},{"v":6.4423e-34,"d":"6.44E-34"},"up","yes","Tifab","protein_coding","chr17:8431635-8436592:+","gi|68163499|ref|NP_001020200.1|",767,{"v":2E-92,"d":"2.00E-92"},"TRAF-interacting protein with FHA domain-containing protein B [Rattus norvegicus]","gi|672080896|ref|XM_008771443.1|",2890,0,"PREDICTED: Rattus norvegicus TRAF-interacting protein with forkhead-associated domain, family member B (Tifab), transcript variant X1, mRNA","Q5BK67",300,{"v":6e-94,"d":"6.00E-94"},"TRAF-interacting protein with FHA domain-containing protein B",".",".",".",".","pfam00498","FHA","FHA domain. The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.","GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0007356|thorax and anterior abdomen determination;GO:0021559|trigeminal nerve development;GO:0021650|vestibulocochlear nerve formation;GO:0030432|peristalsis;GO:0031223|auditory behavior;GO:0035112|genitalia morphogenesis;GO:0042472|inner ear morphogenesis;GO:0048634|regulation of muscle organ development;GO:0048806|genitalia development;GO:0048839|inner ear development;GO:0050885|neuromuscular process controlling balance;GO:0071626|mastication;GO:0090102|cochlea development;GO:0090103|cochlea morphogenesis;GO:0097094|craniofacial suture morphogenesis;GO:0098583|learned vocalization behavior;GO:1901078|negative regulation of relaxation of muscle;GO:1905747|negative regulation of saliva secretion;GO:1905748|hard palate morphogenesis;",".",".","K23835","TIFB; TRAF-interacting protein with FHA domain-containing protein B"]
["ENSRNOG00000013886",269,22.33417168,86,5.532417684,4.036964119,2.013270764,{"v":2.45745e-34,"d":"2.46E-34"},{"v":1.47819e-33,"d":"1.48E-33"},"up","yes","Fyb1","protein_coding","chr2:55632698-55779629:+","gi|564335481|ref|XP_006232081.1|",3301,0,"PREDICTED: FYN-binding protein isoform X4 [Rattus norvegicus]","gi|672041620|ref|XR_590914.1|",3565,0,"PREDICTED: Rattus norvegicus FYN binding protein (Fyb), transcript variant X7, misc_RNA","O35601",1118,0,"FYN-binding protein 1",".",".",".",".","pfam14603","hSH3","Helically-extended SH3 domain. This domain is the 70 C-terminal residues of ADAP - Adhesion and de-granulation promoting adapter protein. It shows homology to SH3 domains; however, conserved residues of the fold are absent. It thus represents an altered SH3 domain fold. An N-terminal, amphipathic, helix makes extensive contacts to residues of the regular SH3 domain fold thereby creating a composite surface with unusual surface properties. The domain can no longer bind conventional proline-rich peptides. There are key phosphorylation sites within the two hSH3 domains and it would appear that binding at these sites does not materially affect the folding of these regions although the equilibrium towards the unfolded state may be slightly altered. The binding partners of the hSH3 domains are still unknown.","GO:0006955|immune response;GO:0007229|integrin-mediated signaling pathway;GO:0050852|T cell receptor signaling pathway;GO:0072659|protein localization to plasma membrane;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0015629|actin cytoskeleton;GO:0030054|cell junction;GO:0032991|protein-containing complex;","GO:0008289|lipid binding;GO:0044877|protein-containing complex binding;","K17698","FYB, ADAP; FYN binding protein"]
["ENSRNOG00000037839",129,10.71043921,8,0.514643505,20.81137544,4.379300412,{"v":2.58128E-34,"d":"2.58E-34"},{"v":1.55122e-33,"d":"1.55E-33"},"up","yes","P2ry10","protein_coding","chrX:72111264-72212265:+","gi|672087946|ref|XP_008771567.1|",1766,0,"PREDICTED: putative P2Y purinoceptor 10 isoform X2 [Rattus norvegicus]","gi|295148047|ref|NM_001177682.1|",2696,0,"Rattus norvegicus purinergic receptor P2Y10 (P2ry10), mRNA","Q8BFU7",607,0,"Putative P2Y purinoceptor 10",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0035025|positive regulation of Rho protein signal transduction;GO:0035589|G protein-coupled purinergic nucleotide receptor signaling pathway;GO:0051482|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway;","GO:0005887|integral component of plasma membrane;","GO:0004930|G protein-coupled receptor activity;GO:0045028|G protein-coupled purinergic nucleotide receptor activity;","K04274","P2RY10; P2Y purinoceptor 10"]
["ENSRNOG00000006946",440,36.53173063,213,13.70238333,2.666085873,1.414723249,{"v":3.89221e-34,"d":"3.89E-34"},{"v":2.32156E-33,"d":"2.32E-33"},"up","yes","Arhgap9","protein_coding","chr7:63148900-63157524:+","gi|124248581|ref|NP_001074258.1|",3057,0,"rho GTPase-activating protein 9 isoform 1 [Rattus norvegicus]","gi|124248580|ref|NM_001080789.1|",1954,0,"Rattus norvegicus Rho GTPase activating protein 9 (Arhgap9), transcript variant 1, mRNA","Q9BRR9",553,0,"Rho GTPase-activating protein 9",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0007165|signal transduction;GO:0043087|regulation of GTPase activity;","GO:0005737|cytoplasm;","GO:0005096|GTPase activator activity;GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;","K20634","ARHGAP9; Rho GTPase-activating protein 9"]
["ENSRNOG00000068953",472,39.18858377,239,15.37497473,2.548855167,1.349849398,{"v":4.25434e-34,"d":"4.25E-34"},{"v":2.5352e-33,"d":"2.54E-33"},"up","yes","ENSRNOG00000068953","protein_coding","chr1:34959980-34989618:-","gi|672059154|ref|XP_008763709.1|",3178,0,"PREDICTED: MLV-related proviral Env polyprotein-like [Rattus norvegicus]","gi|291490836|gb|AC239701.6|",2620,0,"Rattus norvegicus Y Chr BAC RNAEX-260G02 (Amplicon Express Rat SHR-Akr BAC library) complete sequence","P21415",478,{"v":1e-152,"d":"1.00E-152"},"Envelope glycoprotein",".",".",".",".","pfam00429","TLV_coat","ENV polyprotein (coat polyprotein).",".",".",".",".","."]
["ENSRNOG00000018391",684,56.7902358,422,27.14744491,2.091918263,1.064826482,{"v":5.98573e-34,"d":"5.99E-34"},{"v":3.53728e-33,"d":"3.54E-33"},"up","yes","Cdk2ap2","protein_coding","chr1:201391466-201393137:+","gi|149061936|gb|EDM12359.1|",440,{"v":2e-49,"d":"2.00E-49"},"rCG48066, isoform CRA_b [Rattus norvegicus]","gi|90855793|gb|AC141020.2|",1012,0,"Rattus norvegicus BAC CH230-497A18 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q9CPY4",130,{"v":7e-35,"d":"7.00E-35"},"Cyclin-dependent kinase 2-associated protein 2",".",".",".",".","pfam09806","CDK2AP","Cyclin-dependent kinase 2-associated protein. Members of this family of proteins are cell-growth suppressors, associating with and influencing the biological activities of important cell cycle regulators in the S phase including monomeric non-phosphorylated cyclin-dependent kinase 2 (CDK2) and DNA polymerase alpha/primase. An association between mutations in the gene coding for this protein and oral cancer has been described.","GO:0070507|regulation of microtubule cytoskeleton organization;GO:2000035|regulation of stem cell division;GO:2000134|negative regulation of G1/S transition of mitotic cell cycle;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005874|microtubule;",".",".","."]
["ENSRNOG00000031058",255,21.17179843,79,5.082104617,4.165950926,2.058645845,{"v":1.52602E-33,"d":"1.53E-33"},{"v":8.96007e-33,"d":"8.96E-33"},"up","yes","ENSRNOG00000031058","protein_coding","chrX:14405124-14413849:+","gi|165971260|gb|AAI58678.1|",1455,0,"Was protein [Rattus norvegicus]","gi|165971259|gb|BC158677.1|",1384,0,"Rattus norvegicus Wiskott-Aldrich syndrome homolog (human), mRNA (cDNA clone MGC:187683 IMAGE:8372629), complete cds","P70315",520,{"v":5E-176,"d":"5.00E-176"},"Wiskott-Aldrich syndrome protein homolog",".",".",".",".","pfam00568","WH1","WH1 domain. WASp Homology domain 1 (WH1) domain. WASP is the protein that is defective in Wiskott-Aldrich syndrome (WAS). The majority of point mutations occur within the amino- terminal WH1 domain. The metabotropic glutamate receptors mGluR1alpha and mGluR5 bind a protein called homer, which is a WH1 domain homologue. A subset of WH1 domains has been termed a \"EVH1\" domain and appear to bind a polyproline motif.","GO:0002625|regulation of T cell antigen processing and presentation;GO:0006955|immune response;GO:0008064|regulation of actin polymerization or depolymerization;GO:0008150|biological_process;GO:0008154|actin polymerization or depolymerization;GO:0010591|regulation of lamellipodium assembly;GO:0016197|endosomal transport;GO:0030041|actin filament polymerization;GO:0030048|actin filament-based movement;GO:0032488|Cdc42 protein signal transduction;GO:0042110|T cell activation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051492|regulation of stress fiber assembly;GO:0051497|negative regulation of stress fiber assembly;GO:0071346|cellular response to interferon-gamma;GO:1905168|positive regulation of double-strand break repair via homologous recombination;GO:2000146|negative regulation of cell motility;GO:2000601|positive regulation of Arp2/3 complex-mediated actin nucleation;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005829|cytosol;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0012506|vesicle membrane;GO:0035861|site of double-strand break;GO:0045335|phagocytic vesicle;","GO:0003674|molecular_function;GO:0003779|actin binding;GO:0017124|SH3 domain binding;GO:0019901|protein kinase binding;GO:0031267|small GTPase binding;GO:0042802|identical protein binding;GO:0043274|phospholipase binding;","K05747","WAS; Wiskott-Aldrich syndrome protein"]
["ENSRNOG00000059207",120,9.963199263,5,0.321652191,30.97507041,4.953035657,{"v":1.64146e-33,"d":"1.64E-33"},{"v":9.59387e-33,"d":"9.59E-33"},"up","yes","Oas3","protein_coding","chr12:35779022-35802781:+","gi|57222314|ref|NP_001009493.1|",5928,0,"2'-5'-oligoadenylate synthase 3 [Rattus norvegicus]","gi|57222313|ref|NM_001009493.1|",4003,0,"Rattus norvegicus 2'-5'-oligoadenylate synthetase 3 (Oas3), mRNA","Q5MYT7",2288,0,"2'-5'-oligoadenylate synthase 3",".",".",".",".","pfam10421","OAS1_C","2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus. This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between 320 and 344 at the extreme C-terminal end. Oligoadenylate synthetases are antiviral enzymes that counteract vial attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesize 2'.5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication. This domain is often associated with NTP_transf_2 pfam01909.","GO:0009615|response to virus;GO:0032728|positive regulation of interferon-beta production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0035395|negative regulation of chemokine (C-X-C motif) ligand 9 production;GO:0039529|RIG-I signaling pathway;GO:0039530|MDA-5 signaling pathway;GO:0042742|defense response to bacterium;GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0051607|defense response to virus;GO:0060339|negative regulation of type I interferon-mediated signaling pathway;GO:0060700|regulation of ribonuclease activity;GO:0071639|positive regulation of monocyte chemotactic protein-1 production;GO:0071650|negative regulation of chemokine (C-C motif) ligand 5 production;GO:0071659|negative regulation of IP-10 production;GO:2000342|negative regulation of chemokine (C-X-C motif) ligand 2 production;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016020|membrane;","GO:0001730|2'-5'-oligoadenylate synthetase activity;GO:0003725|double-stranded RNA binding;GO:0005524|ATP binding;GO:0046872|metal ion binding;","K14216","OAS; 2'-5'-oligoadenylate synthetase [EC:2.7.7.84]"]
["ENSRNOG00000015077",526,43.67202344,288,18.5271662,2.357188518,1.237067144,{"v":3.12383e-33,"d":"3.12E-33"},{"v":1.82245E-32,"d":"1.82E-32"},"up","yes","Acsf3","protein_coding","chr19:50835221-50875553:+","gi|672031392|ref|XP_001079424.3|",3137,0,"PREDICTED: acyl-CoA synthetase family member 3, mitochondrial isoform X1 [Rattus norvegicus]","gi|672031391|ref|XM_001079424.5|",2196,0,"PREDICTED: Rattus norvegicus acyl-CoA synthetase family member 3 (Acsf3), transcript variant X1, mRNA","Q3URE1",1079,0,"Acyl-CoA synthetase family member 3, mitochondrial","SMa0150",222,{"v":9e-63,"d":"9.00E-63"},"COG0318","pfam00501","AMP-binding","AMP-binding enzyme.","GO:0006631|fatty acid metabolic process;GO:0006633|fatty acid biosynthetic process;GO:0090410|malonate catabolic process;","GO:0005739|mitochondrion;","GO:0016405|CoA-ligase activity;GO:0016878|acid-thiol ligase activity;GO:0031957|very long-chain fatty acid-CoA ligase activity;GO:0090409|malonyl-CoA synthetase activity;","K18660","ACSF3; malonyl-CoA/methylmalonyl-CoA synthetase [EC:6.2.1.-]"]
["ENSRNOG00000011680",280,23.24746495,97,6.240052504,3.725523933,1.897443331,{"v":4.13501e-33,"d":"4.14E-33"},{"v":2.40579e-32,"d":"2.41E-32"},"up","yes","Il16","protein_coding","chr1:137617944-137718130:-","gi|672037391|ref|XP_008757821.1|",6054,0,"PREDICTED: pro-interleukin-16 isoform X3 [Rattus norvegicus]","gi|672037390|ref|XM_008759599.1|",4894,0,"PREDICTED: Rattus norvegicus interleukin 16 (Il16), transcript variant X1, mRNA","O54824",2101,0,"Pro-interleukin-16",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.","GO:0007165|signal transduction;GO:0008150|biological_process;GO:0010628|positive regulation of gene expression;GO:0019221|cytokine-mediated signaling pathway;GO:0030595|leukocyte chemotaxis;GO:0032722|positive regulation of chemokine production;GO:0032730|positive regulation of interleukin-1 alpha production;GO:0032735|positive regulation of interleukin-12 production;GO:0032755|positive regulation of interleukin-6 production;GO:0050729|positive regulation of inflammatory response;GO:0050930|induction of positive chemotaxis;GO:0051924|regulation of calcium ion transport;GO:1902565|positive regulation of neutrophil activation;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005925|focal adhesion;GO:0016607|nuclear speck;GO:0090543|Flemming body;","GO:0003674|molecular_function;GO:0005125|cytokine activity;GO:0042609|CD4 receptor binding;","K22628","IL16; interleukin 16"]
["ENSRNOG00000003748",120,9.963199263,6,0.385982629,25.81255868,4.690001251,{"v":6.05408e-33,"d":"6.05E-33"},{"v":3.50956e-32,"d":"3.51E-32"},"up","yes","ENSRNOG00000003748","protein_coding","chrX:50361248-50423269:+","gi|157818453|ref|NP_001102788.1|",1492,0,"uncharacterized protein CXorf21 homolog [Rattus norvegicus]","gi|157818452|ref|NM_001109318.1|",1558,0,"Rattus norvegicus similar to chromosome X open reading frame 21 (RGD1565785), mRNA",".",".",".",".",".",".",".",".","pfam15133","DUF4569","Domain of unknown function (DUF4569). This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. This family includes human protein CXorf21.","GO:0034157|positive regulation of toll-like receptor 7 signaling pathway;GO:0034161|positive regulation of toll-like receptor 8 signaling pathway;GO:0035751|regulation of lysosomal lumen pH;GO:0045089|positive regulation of innate immune response;","GO:0036020|endolysosome membrane;",".",".","."]
["ENSRNOG00000022540",587,48.73664973,342,22.00100986,2.215200577,1.147437334,{"v":6.26709e-33,"d":"6.27E-33"},{"v":3.62646e-32,"d":"3.63E-32"},"up","yes","Trex1","protein_coding","chr8:109706613-109708796:-","gi|68163427|ref|NP_001020160.1|",1500,0,"three-prime repair exonuclease 1 [Rattus norvegicus]","gi|298884379|emb|FQ233170.1|",1065,0,"Rattus norvegicus TL0AEA62YO17 mRNA sequence","Q91XB0",446,{"v":3e-151,"d":"3.00E-151"},"Three-prime repair exonuclease 1",".",".",".",".","pfam00929","RNase_T","Exonuclease. This family includes a variety of exonuclease proteins, such as ribonuclease T and the epsilon subunit of DNA polymerase III.;","GO:0000077|DNA damage checkpoint;GO:0000738|DNA catabolic process, exonucleolytic;GO:0001568|blood vessel development;GO:0001822|kidney development;GO:0002250|adaptive immune response;GO:0002251|organ or tissue specific immune response;GO:0002253|activation of immune response;GO:0002281|macrophage activation involved in immune response;GO:0002320|lymphoid progenitor cell differentiation;GO:0002383|immune response in brain or nervous system;GO:0002437|inflammatory response to antigenic stimulus;GO:0002457|T cell antigen processing and presentation;GO:0002637|regulation of immunoglobulin production;GO:0003007|heart morphogenesis;GO:0003015|heart process;GO:0003228|atrial cardiac muscle tissue development;GO:0006091|generation of precursor metabolites and energy;GO:0006110|regulation of glycolytic process;GO:0006259|DNA metabolic process;GO:0006260|DNA replication;GO:0006304|DNA modification;GO:0006308|DNA catabolic process;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0006974|cellular response to DNA damage stimulus;GO:0008340|determination of adult lifespan;GO:0009411|response to UV;GO:0010468|regulation of gene expression;GO:0019217|regulation of fatty acid metabolic process;GO:0031323|regulation of cellular metabolic process;GO:0031571|mitotic G1 DNA damage checkpoint;GO:0032197|transposition, RNA-mediated;GO:0032479|regulation of type I interferon production;GO:0032508|DNA duplex unwinding;GO:0032680|regulation of tumor necrosis factor production;GO:0034599|cellular response to oxidative stress;GO:0034614|cellular response to reactive oxygen species;GO:0034644|cellular response to UV;GO:0035458|cellular response to interferon-beta;GO:0035781|CD86 biosynthetic process;GO:0043277|apoptotic cell clearance;GO:0043457|regulation of cellular respiration;GO:0045087|innate immune response;GO:0045088|regulation of innate immune response;GO:0045184|establishment of protein localization;GO:0046890|regulation of lipid biosynthetic process;GO:0050727|regulation of inflammatory response;GO:0050790|regulation of catalytic activity;GO:0050821|protein stabilization;GO:0050863|regulation of T cell activation;GO:0051607|defense response to virus;GO:0060337|type I interferon signaling pathway;GO:0060339|negative regulation of type I interferon-mediated signaling pathway;GO:0061635|regulation of protein complex stability;GO:0071310|cellular response to organic substance;GO:0071357|cellular response to type I interferon;GO:0071480|cellular response to gamma radiation;GO:0072711|cellular response to hydroxyurea;GO:0097281|immune complex formation;GO:1904161|DNA synthesis involved in UV-damage excision repair;GO:1905671|regulation of lysosome organization;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;GO:0008250|oligosaccharyltransferase complex;GO:0016021|integral component of membrane;GO:0032993|protein-DNA complex;GO:0043596|nuclear replication fork;","GO:0000287|magnesium ion binding;GO:0003677|DNA binding;GO:0003690|double-stranded DNA binding;GO:0003697|single-stranded DNA binding;GO:0008296|3'-5'-exodeoxyribonuclease activity;GO:0008301|DNA binding, bending;GO:0008408|3'-5' exonuclease activity;GO:0032405|MutLalpha complex binding;GO:0032407|MutSalpha complex binding;GO:0032558|adenyl deoxyribonucleotide binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0050699|WW domain binding;","K10790","TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]"]
["ENSRNOG00000015577",484,40.18490369,256,16.46859218,2.440093438,1.286936393,{"v":1.46001E-32,"d":"1.46E-32"},{"v":8.38763e-32,"d":"8.39E-32"},"up","yes","Lpar6","protein_coding","chr15:48416544-48422331:+","gi|113951677|ref|NP_001039308.1|",1744,0,"lysophosphatidic acid receptor 6 [Rattus norvegicus]","gi|113951676|ref|NM_001045843.1|",1810,0,"Rattus norvegicus lysophosphatidic acid receptor 6 (Lpar6), mRNA","Q4G072",676,0,"Lysophosphatidic acid receptor 6",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001835|blastocyst hatching;GO:0035025|positive regulation of Rho protein signal transduction;GO:0051482|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;","GO:0004930|G protein-coupled receptor activity;GO:0070915|lysophosphatidic acid receptor activity;","K04273","LPAR6, P2RY5; lysophosphatidic acid receptor 6"]
["ENSRNOG00000049766",167,13.86545231,29,1.865582707,7.432236723,2.893796454,{"v":1.50184E-32,"d":"1.50E-32"},{"v":8.62019e-32,"d":"8.62E-32"},"up","yes","Sctr","protein_coding","chr13:31127858-31180189:+","gi|13592081|ref|NP_112377.1|",2086,0,"secretin receptor precursor [Rattus norvegicus]","gi|51859272|gb|BC081781.1|",1393,0,"Rattus norvegicus secretin receptor, mRNA (cDNA clone MGC:93381 IMAGE:7189388), complete cds","P23811",808,0,"Secretin receptor",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0002024|diet induced thermogenesis;GO:0007166|cell surface receptor signaling pathway;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007188|adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007420|brain development;GO:0009992|cellular water homeostasis;GO:0031667|response to nutrient levels;GO:0032098|regulation of appetite;GO:0043950|positive regulation of cAMP-mediated signaling;GO:0048167|regulation of synaptic plasticity;GO:0050996|positive regulation of lipid catabolic process;GO:0070295|renal water absorption;","GO:0005881|cytoplasmic microtubule;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0008528|G protein-coupled peptide receptor activity;GO:0015055|secretin receptor activity;GO:0017046|peptide hormone binding;GO:0042277|peptide binding;","K04588","SCTR; secretin receptor"]
["ENSRNOG00000006079",249,20.67363847,78,5.017774178,4.120081481,2.042672869,{"v":1.75307E-32,"d":"1.75E-32"},{"v":1.00262e-31,"d":"1.00E-31"},"up","yes","Psd4","protein_coding","chr3:7137155-7173571:+","gi|199561637|ref|NP_001128353.1|",4600,0,"PH and SEC7 domain-containing protein 4 [Rattus norvegicus]","gi|199561636|ref|NM_001134881.1|",4791,0,"Rattus norvegicus pleckstrin and Sec7 domain containing 4 (Psd4), mRNA","Q8BLR5",1566,0,"PH and SEC7 domain-containing protein 4","YDR170c",106,{"v":5e-22,"d":"5.00E-22"},"COG5307","pfam01369","Sec7","Sec7 domain. The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.","GO:0032012|regulation of ARF protein signal transduction;GO:0050790|regulation of catalytic activity;","GO:0032587|ruffle membrane;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0005543|phospholipid binding;","K12494","PSD; PH and SEC7 domain-containing protein"]
["ENSRNOG00000018804",418,34.7051441,203,13.05907895,2.657549145,1.410096371,{"v":2.31492e-32,"d":"2.31E-32"},{"v":1.31924e-31,"d":"1.32E-31"},"up","yes","Ripor2","protein_coding","chr17:40323867-40548092:-","gi|564391393|ref|XP_006253992.1|",5439,0,"PREDICTED: protein FAM65B isoform X2 [Rattus norvegicus]","gi|564391392|ref|XM_006253930.1|",5217,0,"PREDICTED: Rattus norvegicus family with sequence similarity 65, member B (Fam65b), transcript variant X2, mRNA","Q80U16",1979,0,"Rho family-interacting cell polarization regulator 2",".",".",".",".","pfam04065","Not3","Not1 N-terminal domain, CCR4-Not complex component.","GO:0006935|chemotaxis;GO:0007155|cell adhesion;GO:0007162|negative regulation of cell adhesion;GO:0007605|sensory perception of sound;GO:0035024|negative regulation of Rho protein signal transduction;GO:0042130|negative regulation of T cell proliferation;GO:0045184|establishment of protein localization;GO:0045663|positive regulation of myoblast differentiation;GO:0048741|skeletal muscle fiber development;GO:0051260|protein homooligomerization;GO:0051491|positive regulation of filopodium assembly;GO:0051726|regulation of cell cycle;GO:0060088|auditory receptor cell stereocilium organization;GO:0071260|cellular response to mechanical stimulus;GO:0090023|positive regulation of neutrophil chemotaxis;GO:1901673|regulation of mitotic spindle assembly;GO:1901741|positive regulation of myoblast fusion;GO:1903904|negative regulation of establishment of T cell polarity;GO:1905872|negative regulation of protein localization to cell leading edge;GO:1990869|cellular response to chemokine;GO:2000114|regulation of establishment of cell polarity;GO:2000391|positive regulation of neutrophil extravasation;GO:2000405|negative regulation of T cell migration;GO:2001107|negative regulation of Rho guanyl-nucleotide exchange factor activity;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0016324|apical plasma membrane;GO:0030175|filopodium;GO:0032420|stereocilium;GO:0060171|stereocilium membrane;","GO:0008199|ferric iron binding;GO:0042802|identical protein binding;GO:0071889|14-3-3 protein binding;","K24818","RIPOR, FAM65; Rho family-interacting cell polarization regulator"]
["ENSRNOG00000014202",228,18.9300786,65,4.181478482,4.527125676,2.178595357,{"v":2.75073e-32,"d":"2.75E-32"},{"v":1.5662E-31,"d":"1.57E-31"},"up","yes","Snx20","protein_coding","chr19:18435935-18445107:+","gi|672084453|ref|XP_008770624.1|",1456,0,"PREDICTED: sorting nexin-20 isoform X1 [Rattus norvegicus]","gi|68163432|ref|NM_001024999.1|",1368,0,"Rattus norvegicus sorting nexin 20 (Snx20), mRNA","Q5BK61",556,0,"Sorting nexin-20",".",".",".",".","pfam00787","PX","PX domain. PX domains bind to phosphoinositides.","GO:0015031|protein transport;","GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0031901|early endosome membrane;","GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0032266|phosphatidylinositol-3-phosphate binding;GO:1901981|phosphatidylinositol phosphate binding;","K17931","SNX20; sorting nexin-20"]
["ENSRNOG00000033693",117,9.714119281,6,0.385982629,25.16724471,4.653475375,{"v":4.50906e-32,"d":"4.51E-32"},{"v":2.55145e-31,"d":"2.55E-31"},"up","yes","AC135826.1","protein_coding","chr2:31507424-31570542:-","gi|564299708|ref|XP_006224055.1|",7483,0,"PREDICTED: baculoviral IAP repeat-containing protein 1b [Rattus norvegicus]","gi|672041330|ref|XM_008760697.1|",3876,0,"PREDICTED: Rattus norvegicus NLR family, apoptosis inhibitory protein 6 (Naip6), transcript variant X5, mRNA","Q9QUK4",2503,0,"Baculoviral IAP repeat-containing protein 1b",".",".",".",".","pfam05729","NACHT","NACHT domain. This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.",".",".",".",".","."]
["ENSRNOG00000064984",351,29.14235784,153,9.842557042,2.960852319,1.566012534,{"v":8.73983e-32,"d":"8.74E-32"},{"v":4.91498E-31,"d":"4.91E-31"},"up","yes","Plscr2","protein_coding","chr8:92808398-92845932:+","gi|149018896|gb|EDL77537.1|",1522,0,"rCG25051 [Rattus norvegicus]","gi|672062711|ref|XM_008766450.1|",1586,0,"PREDICTED: Rattus norvegicus phospholipid scramblase 2 (Plscr2), transcript variant X1, mRNA","Q9DCW2",549,0,"Phospholipid scramblase 2",".",".",".",".","pfam03803","Scramblase","Scramblase. Scramblase is palmitoylated and contains a potential protein kinase C phosphorylation site. Scramblase exhibits Ca2+-activated phospholipid scrambling activity in vitro. There are also possible SH3 and WW binding motifs. Scramblase is involved in the redistribution of phospholipids after cell activation or injury.",".",".",".",".","."]
["ENSRNOG00000011427",287,23.82865157,106,6.819026448,3.49443601,1.805059628,{"v":8.76018e-32,"d":"8.76E-32"},{"v":4.9221e-31,"d":"4.92E-31"},"up","yes","Hr","protein_coding","chr15:45626835-45646313:+","gi|564386936|ref|XP_006252345.1|",5890,0,"PREDICTED: lysine-specific demethylase hairless isoform X1 [Rattus norvegicus]","gi|560879443|ref|NM_024364.3|",5617,0,"Rattus norvegicus hair growth associated (Hr), mRNA","P97609",2241,0,"Lysine-specific demethylase hairless",".",".",".",".","pfam02373","JmjC","JmjC domain, hydroxylase. The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyse a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalyzing hydroxylation.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0033169|histone H3-K9 demethylation;GO:0043433|negative regulation of DNA-binding transcription factor activity;GO:0045892|negative regulation of transcription, DNA-templated;","GO:0000118|histone deacetylase complex;GO:0000785|chromatin;GO:0005654|nucleoplasm;GO:0016604|nuclear body;","GO:0003712|transcription coregulator activity;GO:0003714|transcription corepressor activity;GO:0016491|oxidoreductase activity;GO:0031490|chromatin DNA binding;GO:0032454|histone demethylase activity (H3-K9 specific);GO:0042809|vitamin D receptor binding;GO:0042826|histone deacetylase binding;GO:0044877|protein-containing complex binding;GO:0046872|metal ion binding;GO:0046966|thyroid hormone receptor binding;","K00478","HR; [histone H3]-dimethyl-L-lysine9 demethylase [EC:1.14.11.65]"]
["ENSRNOG00000067073",431,35.78449069,216,13.89537465,2.575280739,1.364729713,{"v":8.77982E-32,"d":"8.78E-32"},{"v":4.92483e-31,"d":"4.92E-31"},"up","yes","Med18","protein_coding","chr5:144663252-144668635:-","gi|194382240|dbj|BAG58875.1|",918,{"v":4E-116,"d":"4.00E-116"},"unnamed protein product [Homo sapiens]","gi|672054207|ref|XM_008764174.1|",1247,0,"PREDICTED: Rattus norvegicus similar to mediator of RNA polymerase II transcription, subunit 18 homolog (LOC682988), transcript variant X1, mRNA","Q9CZ82",356,{"v":4e-117,"d":"4.00E-117"},"Mediator of RNA polymerase II transcription subunit 18",".",".",".",".","pfam09637","Med18","Med18 protein. Med18 is one subunit of Mediator, a head-module multiprotein complex, that stimulates basal RNA polymerase II (Pol II) transcription. Med18 consists of an eight-stranded beta-barrel with a central pore and three flanking helices. It complexes with Med8 and Med20 proteins by forming a heterodimer of two-fold symmetry with Med20 and binding the C-terminal alpha-helix region of Med8 across the top of its barrel. This complex creates a multipartite TBP-binding site that can be modulated by transcriptional activators.",".",".",".",".","."]
["ENSRNOG00000020872",129,10.71043921,12,0.771965258,13.87425029,3.794337911,{"v":1.0991e-31,"d":"1.10E-31"},{"v":6.15388e-31,"d":"6.15E-31"},"up","yes","Cd5","protein_coding","chr1:207365337-207386313:-","gi|149062413|gb|EDM12836.1|",2216,0,"CD5 antigen, isoform CRA_b [Rattus norvegicus]","gi|9506470|ref|NM_019295.1|",2016,0,"Rattus norvegicus Cd5 molecule (Cd5), mRNA","P51882",857,0,"T-cell surface glycoprotein CD5",".",".",".",".","pfam00530","SRCR","Scavenger receptor cysteine-rich domain. These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.","GO:0006897|endocytosis;GO:0009966|regulation of signal transduction;GO:0031295|T cell costimulation;GO:0097190|apoptotic signaling pathway;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0044214|spanning component of plasma membrane;","GO:0005044|scavenger receptor activity;GO:0005515|protein binding;","K06455","CD5; T-cell surface glycoprotein CD5"]
["ENSRNOG00000014125",159,13.20123902,27,1.736921831,7.6003645,2.926068609,{"v":2.13942e-31,"d":"2.14E-31"},{"v":1.1885E-30,"d":"1.19E-30"},"up","yes","Evi2b","protein_coding","chr10:64471505-64481560:-","gi|407228403|ref|NP_001258411.1|",1428,0,"protein EVI2B precursor [Rattus norvegicus]","gi|281371508|gb|AC123294.3|",2912,0,"Rattus norvegicus BAC CH230-333F9 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q8VD58",377,{"v":4e-118,"d":"4.00E-118"},"Protein EVI2B",".",".",".",".","pfam12051","DUF3533","Protein of unknown function (DUF3533). This family of transmembrane proteins is functionally uncharacterized. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 393 to 772 amino acids in length.","GO:0030854|positive regulation of granulocyte differentiation;GO:0045660|positive regulation of neutrophil differentiation;GO:2000035|regulation of stem cell division;","GO:0016021|integral component of membrane;",".","K16854","EVI2B, CD361; ecotropic viral integration site 2B protein"]
["ENSRNOG00000047307",157,13.0351857,26,1.672591393,7.79340714,2.962254187,{"v":2.23179e-31,"d":"2.23E-31"},{"v":1.23874E-30,"d":"1.24E-30"},"up","yes","Cntfr","protein_coding","chr5:56823965-56841392:-","gi|149045684|gb|EDL98684.1|",1676,0,"ciliary neurotrophic factor receptor, isoform CRA_b [Rattus norvegicus]","gi|51556266|ref|NM_001003929.1|",1242,0,"Rattus norvegicus ciliary neurotrophic factor receptor (Cntfr), mRNA","Q08406",648,0,"Ciliary neurotrophic factor receptor subunit alpha",".",".",".",".","pfam00041","fn3","Fibronectin type III domain.","GO:0001967|suckling behavior;GO:0003360|brainstem development;GO:0007548|sex differentiation;GO:0008284|positive regulation of cell proliferation;GO:0019221|cytokine-mediated signaling pathway;GO:0043524|negative regulation of neuron apoptotic process;GO:0060538|skeletal muscle organ development;GO:0070120|ciliary neurotrophic factor-mediated signaling pathway;","GO:0009897|external side of plasma membrane;GO:0016324|apical plasma membrane;GO:0031225|anchored component of membrane;GO:0043235|receptor complex;GO:0070110|ciliary neurotrophic factor receptor complex;GO:0097059|CNTFR-CLCF1 complex;","GO:0004896|cytokine receptor activity;GO:0004897|ciliary neurotrophic factor receptor activity;GO:0005102|signaling receptor binding;GO:0019955|cytokine binding;","K05059","CNTFR; ciliary neurotrophic factor receptor"]
["ENSRNOG00000010575",265,22.00206504,92,5.918400313,3.717569592,1.89435975,{"v":2.31642e-31,"d":"2.32E-31"},{"v":1.28238e-30,"d":"1.28E-30"},"up","yes","Dapp1","protein_coding","chr2:226425898-226475423:-","gi|157819323|ref|NP_001102038.1|",1504,0,"dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide [Rattus norvegicus]","gi|157819322|ref|NM_001108568.1|",3045,0,"Rattus norvegicus dual adaptor of phosphotyrosine and 3-phosphoinositides (Dapp1), mRNA","Q9QXT1",565,0,"Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide",".",".",".",".","pfam00017","SH2","SH2 domain.",".","GO:0005886|plasma membrane;","GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;GO:0043325|phosphatidylinositol-3,4-bisphosphate binding;","K12229","DAPP1, BAM32; dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide"]
["ENSRNOG00000018406",569,47.24216984,335,21.55069679,2.192141177,1.132340713,{"v":2.46688e-31,"d":"2.47E-31"},{"v":1.36213e-30,"d":"1.36E-30"},"up","yes","Wipf1","protein_coding","chr3:58314542-58372742:-","gi|60390706|sp|Q6IN36.2|WIPF1_RAT",994,{"v":7e-118,"d":"7.00E-118"},"RecName: Full=WAS/WASL-interacting protein family member 1; AltName: Full=Wiskott-Aldrich syndrome protein-interacting protein; Short=WASP-interacting protein","gi|48675857|ref|NM_057192.2|",3944,0,"Rattus norvegicus WAS/WASL interacting protein family, member 1 (Wipf1), mRNA","Q6IN36",387,{"v":2E-119,"d":"2.00E-119"},"WAS/WASL-interacting protein family member 1",".",".",".",".","pfam02205","WH2","WH2 motif. The WH2 motif (for Wiskott Aldrich syndrome homology region 2) has been shown in WASP and Scar1 (mammalian homologue) to be the region that interacts with actin.","GO:0008154|actin polymerization or depolymerization;GO:0030036|actin cytoskeleton organization;GO:0030048|actin filament-based movement;GO:0046827|positive regulation of protein export from nucleus;GO:0051707|response to other organism;","GO:0001726|ruffle;GO:0005884|actin filament;GO:0015629|actin cytoskeleton;GO:0031410|cytoplasmic vesicle;","GO:0003779|actin binding;GO:0005515|protein binding;GO:0017124|SH3 domain binding;","K19475","WIPF; WAS/WASL-interacting protein"]
["ENSRNOG00000067213",160,13.28426568,28,1.801252269,7.375016765,2.882646329,{"v":3.8395e-31,"d":"3.84E-31"},{"v":2.1001e-30,"d":"2.10E-30"},"up","yes","ENSRNOG00000067213","lncRNA","chr20:4843599-4848714:-","gi|149043382|gb|EDL96833.1|",493,{"v":4e-54,"d":"4.00E-54"},"rCG60897, partial [Rattus norvegicus]","gi|46237532|emb|BX883042.1|",1283,0,"Rattus norvegicus chromosome 20, major histocompatibility complex, assembled from 40 BACs, strain Brown Norway (BN/ssNHsd), RT1n haplotype; segment 1/11","P16391",157,{"v":2e-40,"d":"2.00E-40"},"RT1 class I histocompatibility antigen, AA alpha chain",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.",".",".",".",".","."]
["ENSRNOG00000065311",156,12.95215904,26,1.672591393,7.743767604,2.953035657,{"v":4.2399e-31,"d":"4.24E-31"},{"v":2.31317e-30,"d":"2.31E-30"},"up","yes","RT1-CE15","protein_coding","chr20:3264172-3279563:-","gi|676260230|dbj|BAP46322.1|",689,0,"gag protein [Chlorocebus sabaeus]","gi|46237639|emb|BX883047.1|",7315,0,"Rattus norvegicus chromosome 20, major histocompatibility complex, assembled from 40 BACs, strain Brown Norway (BN/ssNHsd), RT1n haplotype; segment 6/11","P07572",815,0,"Gag-Pro-Pol polyprotein",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.",".",".",".",".","."]
["ENSRNOG00000010646",255,21.17179843,86,5.532417684,3.826861897,1.936161838,{"v":4.36132e-31,"d":"4.36E-31"},{"v":2.37739E-30,"d":"2.38E-30"},"up","yes","Tmem229b","protein_coding","chr6:97775332-97819489:-","gi|564356481|ref|XP_006240337.1|",940,{"v":2E-113,"d":"2.00E-113"},"PREDICTED: transmembrane protein 229B isoform X2 [Rattus norvegicus]","gi|157819610|ref|NM_001109359.1|",3515,0,"Rattus norvegicus transmembrane protein 229B (Tmem229b), mRNA","Q8BFQ2",346,{"v":2e-108,"d":"2.00E-108"},"Transmembrane protein 229B",".",".",".",".","pfam06541","DUF1113","Protein of unknown function (DUF1113). This family consists of several bacterial proteins of unknown function.","GO:0009617|response to bacterium;","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000018915",129,10.71043921,13,0.836295696,12.80700027,3.678860693,{"v":4.87358e-31,"d":"4.87E-31"},{"v":2.6521e-30,"d":"2.65E-30"},"up","yes","Tagap","protein_coding","chr1:47170725-47179792:-","gi|827342578|ref|NP_001296378.1|",3627,0,"T-cell activation Rho GTPase-activating protein [Rattus norvegicus]","gi|672012747|ref|XM_003753172.3|",3184,0,"PREDICTED: Rattus norvegicus T-cell activation RhoGTPase activating protein (Tagap), transcript variant X1, mRNA","B2RWW0",1198,0,"T-cell activation Rho GTPase-activating protein",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0007165|signal transduction;GO:0050790|regulation of catalytic activity;GO:0051607|defense response to virus;",".","GO:0005096|GTPase activator activity;","K20654","TAGAP, ARHGAP47; T-cell activation Rho GTPase-activating protein"]
["ENSRNOG00000027466",131,10.87649253,14,0.900626135,12.07658995,3.594141236,{"v":5.52205e-31,"d":"5.52E-31"},{"v":2.99479e-30,"d":"2.99E-30"},"up","yes","Cd27","protein_coding","chr4:158030703-158035592:-","gi|557948013|ref|NP_001273682.1|",806,{"v":1e-102,"d":"1.00E-102"},"CD27 antigen isoform c precursor [Mus musculus]","gi|66730456|ref|NM_001024335.1|",1061,0,"Rattus norvegicus CD27 molecule (Cd27), mRNA","P41272",270,{"v":1e-85,"d":"1.00E-85"},"CD27 antigen",".",".",".",".","pfam00020","TNFR_c6","TNFR/NGFR cysteine-rich region.","GO:0043066|negative regulation of apoptotic process;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045471|response to ethanol;GO:0045579|positive regulation of B cell differentiation;GO:0045582|positive regulation of T cell differentiation;GO:0046330|positive regulation of JNK cascade;GO:0070233|negative regulation of T cell apoptotic process;GO:0097191|extrinsic apoptotic signaling pathway;","GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0004888|transmembrane signaling receptor activity;GO:0043027|cysteine-type endopeptidase inhibitor activity involved in apoptotic process;","K05144","TNFRSF7, CD27; tumor necrosis factor receptor superfamily member 7"]
["ENSRNOG00000071212",327,27.14971799,138,8.87760047,3.058227061,1.612695525,{"v":6.02971e-31,"d":"6.03E-31"},{"v":3.26734E-30,"d":"3.27E-30"},"up","yes","ENSRNOG00000071212","lncRNA","chr19:47467970-47480763:-","gi|148701441|gb|EDL33388.1|",220,{"v":2E-19,"d":"2.00E-19"},"mCG1045525, partial [Mus musculus]","gi|354785512|gb|JN950013.1|",138,{"v":5e-64,"d":"5.00E-64"},"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Nkiras2:tm1e(EUCOMM)Wtsi; transgenic","P46935",52.4,4e-06,"E3 ubiquitin-protein ligase NEDD4",".",".",".",".","pfam09898","DUF2125","Uncharacterized protein conserved in bacteria (DUF2125). This domain, found in various hypothetical prokaryotic proteins, has no known function.",".",".",".",".","."]
["ENSRNOG00000009347",316,26.23642473,130,8.362956964,3.13721867,1.649486091,{"v":6.83225e-31,"d":"6.83E-31"},{"v":3.69908e-30,"d":"3.70E-30"},"up","yes","Arhgap25","protein_coding","chr4:119896844-119974982:-","gi|157823601|ref|NP_001102717.1|",3289,0,"rho GTPase-activating protein 25 [Rattus norvegicus]","gi|157823600|ref|NM_001109247.1|",2982,0,"Rattus norvegicus Rho GTPase activating protein 25 (Arhgap25), mRNA","Q8BYW1",1216,0,"Rho GTPase-activating protein 25",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0006911|phagocytosis, engulfment;GO:0007015|actin filament organization;GO:0007165|signal transduction;GO:0051058|negative regulation of small GTPase mediated signal transduction;GO:0090630|activation of GTPase activity;","GO:0001891|phagocytic cup;","GO:0005096|GTPase activator activity;","K20642","ARHGAP22_24_25; Rho GTPase-activating protein 22/24/25"]
["ENSRNOG00000007439",436,36.19962399,225,14.47434859,2.50095013,1.32247629,{"v":1.06886E-30,"d":"1.07E-30"},{"v":5.77716e-30,"d":"5.78E-30"},"up","yes","Unc13d","protein_coding","chr10:101296776-101311687:-","gi|564375177|ref|XP_006247764.1|",5567,0,"PREDICTED: protein unc-13 homolog D isoform X1 [Rattus norvegicus]","gi|672069607|ref|XM_006247702.2|",4202,0,"PREDICTED: Rattus norvegicus unc-13 homolog D (C. elegans) (Unc13d), transcript variant X1, mRNA","Q9R189",2078,0,"Protein unc-13 homolog D",".",".",".",".","pfam10540","Membr_traf_MHD","Munc13 (mammalian uncoordinated) homology domain. Munc13 proteins constitute a family of three highly homologous molecules (Munc13-1, Munc13-2 and Munc13-3) with homology to Caenorhabditis elegans unc-13p. Munc13 proteins contain a phorbol ester-binding C1 domain and two C2 domains, which are Ca2+/phospholipid binding domains. Sequence analyses have uncovered two regions called Munc13 homology domains 1 (MHD1) and 2 (MHD2) that are arranged between two flanking C2 domains. MHD1 and MHD2 domains are present in a wide variety of proteins from Arabidopsis thaliana, C. elegans, Drosophila melanogaster, mouse, rat and human, some of which may function in a Munc13-like manner to regulate membrane trafficking. The MHD1 and MHD2 domains are predicted to be alpha-helical.","GO:0002432|granuloma formation;GO:0002467|germinal center formation;GO:0006887|exocytosis;GO:0006909|phagocytosis;GO:0043304|regulation of mast cell degranulation;GO:0043320|natural killer cell degranulation;GO:0045921|positive regulation of exocytosis;GO:0046903|secretion;GO:0051607|defense response to virus;GO:0061789|dense core granule priming;GO:1900026|positive regulation of substrate adhesion-dependent cell spreading;GO:1903307|positive regulation of regulated secretory pathway;","GO:0005575|cellular_component;GO:0005764|lysosome;GO:0005770|late endosome;GO:0005829|cytosol;GO:0016020|membrane;GO:0033093|Weibel-Palade body;GO:0043231|intracellular membrane-bounded organelle;GO:0055037|recycling endosome;GO:0070382|exocytic vesicle;","GO:0003674|molecular_function;GO:0031267|small GTPase binding;GO:0046872|metal ion binding;","K19728","UNC13D, MUNC13; protein unc-13 D"]
["ENSRNOG00000002540",185,15.3599322,43,2.766208842,5.552701576,2.473189862,{"v":1.40536E-30,"d":"1.41E-30"},{"v":7.57676e-30,"d":"7.58E-30"},"up","yes","Rhoh","protein_coding","chr14:42337751-42386369:-","gi|61740627|ref|NP_001013448.1|",1024,{"v":3E-124,"d":"3.00E-124"},"rho-related GTP-binding protein RhoH [Rattus norvegicus]","gi|61740626|ref|NM_001013430.1|",1251,0,"Rattus norvegicus ras homolog family member H (Rhoh), mRNA","Q9D3G9",394,{"v":2e-124,"d":"2.00E-124"},"Rho-related GTP-binding protein RhoH","SPAC110.03",156,{"v":3e-41,"d":"3.00E-41"},"COG1100","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0007015|actin filament organization;GO:0007163|establishment or maintenance of cell polarity;GO:0008045|motor neuron axon guidance;GO:0008360|regulation of cell shape;GO:0016601|Rac protein signal transduction;GO:0030031|cell projection assembly;GO:0030217|T cell differentiation;GO:0030865|cortical cytoskeleton organization;GO:0032956|regulation of actin cytoskeleton organization;GO:0043086|negative regulation of catalytic activity;GO:0043124|negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043652|engulfment of apoptotic cell;GO:0045576|mast cell activation;GO:0045582|positive regulation of T cell differentiation;GO:1902622|regulation of neutrophil migration;","GO:0001772|immunological synapse;GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0005938|cell cortex;GO:0031410|cytoplasmic vesicle;GO:0042995|cell projection;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0019210|kinase inhibitor activity;GO:0019901|protein kinase binding;","K07873","RHOH, TTF; Ras homolog gene family, member H"]
["ENSRNOG00000009822",169,14.03150563,34,2.187234898,6.415180025,2.681489751,{"v":1.49424E-30,"d":"1.49E-30"},{"v":8.04237e-30,"d":"8.04E-30"},"up","yes","Tlr2","protein_coding","chr2:169197419-169206630:-","gi|672042714|ref|XP_008759324.1|",3768,0,"PREDICTED: toll-like receptor 2 isoform X1 [Rattus norvegicus]","gi|672042713|ref|XM_008761102.1|",3103,0,"PREDICTED: Rattus norvegicus toll-like receptor 2 (Tlr2), transcript variant X1, mRNA","Q9QUN7",1299,0,"Toll-like receptor 2",".",".",".",".","pfam01582","TIR","TIR domain. The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.","GO:0001666|response to hypoxia;GO:0001774|microglial cell activation;GO:0001775|cell activation;GO:0001819|positive regulation of cytokine production;GO:0002224|toll-like receptor signaling pathway;GO:0002238|response to molecule of fungal origin;GO:0002687|positive regulation of leukocyte migration;GO:0002730|regulation of dendritic cell cytokine production;GO:0002752|cell surface pattern recognition receptor signaling pathway;GO:0002755|MyD88-dependent toll-like receptor signaling pathway;GO:0006691|leukotriene metabolic process;GO:0006952|defense response;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007252|I-kappaB phosphorylation;GO:0007612|learning;GO:0008285|negative regulation of cell proliferation;GO:0009617|response to bacterium;GO:0009636|response to toxic substance;GO:0010628|positive regulation of gene expression;GO:0014005|microglia development;GO:0030177|positive regulation of Wnt signaling pathway;GO:0030837|negative regulation of actin filament polymerization;GO:0032289|central nervous system myelin formation;GO:0032493|response to bacterial lipoprotein;GO:0032494|response to peptidoglycan;GO:0032496|response to lipopolysaccharide;GO:0032570|response to progesterone;GO:0032695|negative regulation of interleukin-12 production;GO:0032700|negative regulation of interleukin-17 production;GO:0032722|positive regulation of chemokine production;GO:0032728|positive regulation of interferon-beta production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032733|positive regulation of interleukin-10 production;GO:0032735|positive regulation of interleukin-12 production;GO:0032741|positive regulation of interleukin-18 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032868|response to insulin;GO:0034123|positive regulation of toll-like receptor signaling pathway;GO:0034134|toll-like receptor 2 signaling pathway;GO:0042495|detection of triacyl bacterial lipopeptide;GO:0042496|detection of diacyl bacterial lipopeptide;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046209|nitric oxide metabolic process;GO:0048714|positive regulation of oligodendrocyte differentiation;GO:0050729|positive regulation of inflammatory response;GO:0050765|negative regulation of phagocytosis;GO:0050830|defense response to Gram-positive bacterium;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051607|defense response to virus;GO:0051770|positive regulation of nitric-oxide synthase biosynthetic process;GO:0051964|negative regulation of synapse assembly;GO:0060907|positive regulation of macrophage cytokine production;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070542|response to fatty acid;GO:0071221|cellular response to bacterial lipopeptide;GO:0071223|cellular response to lipoteichoic acid;GO:0071224|cellular response to peptidoglycan;GO:0071346|cellular response to interferon-gamma;GO:0071726|cellular response to diacyl bacterial lipopeptide;GO:0071727|cellular response to triacyl bacterial lipopeptide;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1903974|positive regulation of cellular response to macrophage colony-stimulating factor stimulus;GO:1904417|positive regulation of xenophagy;GO:1904466|positive regulation of matrix metallopeptidase secretion;","GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0030670|phagocytic vesicle membrane;GO:0031226|intrinsic component of plasma membrane;GO:0035354|Toll-like receptor 1-Toll-like receptor 2 protein complex;GO:0035355|Toll-like receptor 2-Toll-like receptor 6 protein complex;GO:0042995|cell projection;GO:0044297|cell body;GO:0045121|membrane raft;","GO:0001530|lipopolysaccharide binding;GO:0001540|amyloid-beta binding;GO:0003953|NAD+ nucleosidase activity;GO:0004888|transmembrane signaling receptor activity;GO:0005515|protein binding;GO:0035325|Toll-like receptor binding;GO:0038023|signaling receptor activity;GO:0038187|pattern recognition receptor activity;GO:0042497|triacyl lipopeptide binding;GO:0042498|diacyl lipopeptide binding;GO:0042802|identical protein binding;GO:0042834|peptidoglycan binding;GO:0044877|protein-containing complex binding;GO:0070891|lipoteichoic acid binding;GO:0071723|lipopeptide binding;","K10159","TLR2, CD282; toll-like receptor 2"]
["ENSRNOG00000020918",338,28.06301126,148,9.520904851,2.947515146,1.559499227,{"v":1.70714e-30,"d":"1.71E-30"},{"v":9.14976e-30,"d":"9.15E-30"},"up","yes","Ccnd1","protein_coding","chr1:200089002-200098602:-","gi|672039472|ref|XP_008758390.1|",1433,0,"PREDICTED: G1/S-specific cyclin-D1 isoform X1 [Rattus norvegicus]","gi|672039471|ref|XM_008760168.1|",1506,0,"PREDICTED: Rattus norvegicus cyclin D1 (Ccnd1), transcript variant X1, mRNA","P39948",498,{"v":1e-170,"d":"1.00E-170"},"G1/S-specific cyclin-D1","SPBC582.03",72,{"v":2E-12,"d":"2.00E-12"},"COG5024","pfam00134","Cyclin_N","Cyclin, N-terminal domain. Cyclins regulate cyclin dependent kinases (CDKs). Human cyclin-O is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.","GO:0000079|regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0000082|G1/S transition of mitotic cell cycle;GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0000320|re-entry into mitotic cell cycle;GO:0001889|liver development;GO:0001934|positive regulation of protein phosphorylation;GO:0006468|protein phosphorylation;GO:0006974|cellular response to DNA damage stimulus;GO:0007595|lactation;GO:0008284|positive regulation of cell proliferation;GO:0009410|response to xenobiotic stimulus;GO:0010033|response to organic substance;GO:0010039|response to iron ion;GO:0010165|response to X-ray;GO:0010243|response to organonitrogen compound;GO:0010971|positive regulation of G2/M transition of mitotic cell cycle;GO:0014070|response to organic cyclic compound;GO:0016055|Wnt signaling pathway;GO:0030857|negative regulation of epithelial cell differentiation;GO:0030968|endoplasmic reticulum unfolded protein response;GO:0031100|animal organ regeneration;GO:0031571|mitotic G1 DNA damage checkpoint;GO:0032026|response to magnesium ion;GO:0032355|response to estradiol;GO:0033197|response to vitamin E;GO:0033327|Leydig cell differentiation;GO:0033598|mammary gland epithelial cell proliferation;GO:0033601|positive regulation of mammary gland epithelial cell proliferation;GO:0043627|response to estrogen;GO:0044321|response to leptin;GO:0044772|mitotic cell cycle phase transition;GO:0045444|fat cell differentiation;GO:0045471|response to ethanol;GO:0045737|positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0048545|response to steroid hormone;GO:0051301|cell division;GO:0051384|response to glucocorticoid;GO:0051412|response to corticosterone;GO:0051592|response to calcium ion;GO:0051726|regulation of cell cycle;GO:0060749|mammary gland alveolus development;GO:0070141|response to UV-A;GO:0071310|cellular response to organic substance;GO:0097421|liver regeneration;GO:1900087|positive regulation of G1/S transition of mitotic cell cycle;GO:2000045|regulation of G1/S transition of mitotic cell cycle;","GO:0000307|cyclin-dependent protein kinase holoenzyme complex;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005923|bicellular tight junction;GO:0016020|membrane;GO:0017053|transcriptional repressor complex;GO:0031965|nuclear membrane;","GO:0003714|transcription corepressor activity;GO:0004672|protein kinase activity;GO:0016301|kinase activity;GO:0016538|cyclin-dependent protein serine/threonine kinase regulator activity;GO:0019899|enzyme binding;GO:0019901|protein kinase binding;GO:0042826|histone deacetylase binding;GO:0044877|protein-containing complex binding;GO:0070064|proline-rich region binding;","K04503","CCND1; G1/S-specific cyclin-D1"]
["ENSRNOG00000014350",565,46.9100632,338,21.74368811,2.1574106,1.109300777,{"v":3.63349e-30,"d":"3.63E-30"},{"v":1.92325e-29,"d":"1.92E-29"},"up","yes","Ccn1","protein_coding","chr2:234562408-234565484:-","gi|625223734|ref|XP_003512990.2|",1796,0,"PREDICTED: protein CYR61 isoform X1 [Cricetulus griseus]","gi|31542446|ref|NM_031327.2|",1977,0,"Rattus norvegicus cysteine-rich, angiogenic inducer, 61 (Cyr61), mRNA","Q9ES72",658,0,"Protein CYR61",".",".",".",".","pfam00007","Cys_knot","Cystine-knot domain. The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.","GO:0001649|osteoblast differentiation;GO:0001934|positive regulation of protein phosphorylation;GO:0002041|intussusceptive angiogenesis;GO:0003181|atrioventricular valve morphogenesis;GO:0003278|apoptotic process involved in heart morphogenesis;GO:0003281|ventricular septum development;GO:0006935|chemotaxis;GO:0007155|cell adhesion;GO:0007165|signal transduction;GO:0010518|positive regulation of phospholipase activity;GO:0010811|positive regulation of cell-substrate adhesion;GO:0030198|extracellular matrix organization;GO:0030335|positive regulation of cell migration;GO:0030501|positive regulation of bone mineralization;GO:0030513|positive regulation of BMP signaling pathway;GO:0033690|positive regulation of osteoblast proliferation;GO:0043065|positive regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0043280|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0044319|wound healing, spreading of cells;GO:0045597|positive regulation of cell differentiation;GO:0045669|positive regulation of osteoblast differentiation;GO:0045766|positive regulation of angiogenesis;GO:0045860|positive regulation of protein kinase activity;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0060413|atrial septum morphogenesis;GO:0060548|negative regulation of cell death;GO:0060591|chondroblast differentiation;GO:0060710|chorio-allantoic fusion;GO:0060716|labyrinthine layer blood vessel development;GO:0061036|positive regulation of cartilage development;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:0072593|reactive oxygen species metabolic process;GO:0098609|cell-cell adhesion;GO:2000304|positive regulation of ceramide biosynthetic process;","GO:0005576|extracellular region;GO:0031012|extracellular matrix;","GO:0005178|integrin binding;GO:0005520|insulin-like growth factor binding;GO:0008201|heparin binding;GO:0050840|extracellular matrix binding;","K06829","CYR61, CCN1, IGFBP10; insulin-like growth factor-binding protein 10"]
["ENSRNOG00000017020",435,36.11659733,228,14.66733991,2.462382242,1.300054733,{"v":7.09254e-30,"d":"7.09E-30"},{"v":3.7203e-29,"d":"3.72E-29"},"up","yes","Inpp5d","protein_coding","chr9:88287677-88392746:+","gi|9506813|ref|NP_062184.1|",5734,0,"phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 [Rattus norvegicus]","gi|9506812|ref|NM_019311.1|",4859,0,"Rattus norvegicus inositol polyphosphate-5-phosphatase D (Inpp5d), mRNA","P97573",2197,0,"Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1","YNL106c_2",131,{"v":2e-30,"d":"2.00E-30"},"COG5411","pfam00017","SH2","SH2 domain.","GO:0006915|apoptotic process;GO:0008150|biological_process;GO:0008285|negative regulation of cell proliferation;GO:0008340|determination of adult lifespan;GO:0009968|negative regulation of signal transduction;GO:0016064|immunoglobulin mediated immune response;GO:0030853|negative regulation of granulocyte differentiation;GO:0030889|negative regulation of B cell proliferation;GO:0032715|negative regulation of interleukin-6 production;GO:0035556|intracellular signal transduction;GO:0043065|positive regulation of apoptotic process;GO:0045579|positive regulation of B cell differentiation;GO:0045621|positive regulation of lymphocyte differentiation;GO:0045648|positive regulation of erythrocyte differentiation;GO:0045656|negative regulation of monocyte differentiation;GO:0045659|negative regulation of neutrophil differentiation;GO:0045671|negative regulation of osteoclast differentiation;GO:0045779|negative regulation of bone resorption;GO:0046856|phosphatidylinositol dephosphorylation;GO:0050777|negative regulation of immune response;GO:0050869|negative regulation of B cell activation;","GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0030863|cortical cytoskeleton;GO:0045121|membrane raft;","GO:0004439|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0004445|inositol-polyphosphate 5-phosphatase activity;GO:0005515|protein binding;GO:0016791|phosphatase activity;GO:0017124|SH3 domain binding;GO:0030487|inositol-4,5-bisphosphate 5-phosphatase activity;GO:0034485|phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity;GO:0034594|phosphatidylinositol trisphosphate phosphatase activity;GO:0051425|PTB domain binding;GO:0052658|inositol-1,4,5-trisphosphate 5-phosphatase activity;GO:0052659|inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity;","K03084","SHIP1, INPP5D; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 [EC:3.1.3.86]"]
["ENSRNOG00000068731",129,10.71043921,15,0.964956573,11.09940023,3.472409816,{"v":8.92776e-30,"d":"8.93E-30"},{"v":4.66762e-29,"d":"4.67E-29"},"up","yes","ENSRNOG00000068731","lncRNA","chr5:145217884-145221870:+","gi|148704753|gb|EDL36700.1|",232,{"v":7e-19,"d":"7.00E-19"},"mCG146313, partial [Mus musculus]","gi|23956420|emb|AL627184.18|",580,0,"Mouse DNA sequence from clone RP23-125F21 on chromosome 4, complete sequence",".",".",".",".",".",".",".",".","pfam15180","NPBW","Neuropeptides B and W. The function of this family, NPBW, which includes Neuropeptides B and W, is thought to be involved in activating G-protein coupled receptors, GPR7 and GPR8. It is thought to play a regulatory role in the organisation of neuroendocrine signals accessing the anterior pituitary gland. It is predicted that this effect will stimulate the increase in water-drinking and food-intake. This suggests it plays a role in the hypothalamic response to stress. This family of proteins is found in eukaryotes.",".",".",".",".","."]
["ENSRNOG00000054251",371,30.80289105,178,11.450818,2.690016649,1.427615102,{"v":2.00894e-29,"d":"2.01E-29"},{"v":1.04265E-28,"d":"1.04E-28"},"up","yes","Clec7a","protein_coding","chr4:162902732-162913897:-","gi|187469451|gb|AAI66774.1|",1303,{"v":1e-171,"d":"1.00E-171"},"Clec7a protein [Rattus norvegicus]","gi|290563187|ref|NM_001173386.1|",2426,0,"Rattus norvegicus C-type lectin domain family 7, member A (Clec7a), mRNA","Q6QLQ4",399,{"v":1e-131,"d":"1.00E-131"},"C-type lectin domain family 7 member A",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0001879|detection of yeast;GO:0002223|stimulatory C-type lectin receptor signaling pathway;GO:0002366|leukocyte activation involved in immune response;GO:0002732|positive regulation of dendritic cell cytokine production;GO:0006910|phagocytosis, recognition;GO:0008037|cell recognition;GO:0008284|positive regulation of cell proliferation;GO:0010628|positive regulation of gene expression;GO:0016046|detection of fungus;GO:0030335|positive regulation of cell migration;GO:0031334|positive regulation of protein complex assembly;GO:0032491|detection of molecule of fungal origin;GO:0032729|positive regulation of interferon-gamma production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032733|positive regulation of interleukin-10 production;GO:0032735|positive regulation of interleukin-12 production;GO:0032743|positive regulation of interleukin-2 production;GO:0032747|positive regulation of interleukin-23 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032874|positive regulation of stress-activated MAPK cascade;GO:0032930|positive regulation of superoxide anion generation;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043280|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050766|positive regulation of phagocytosis;GO:0050850|positive regulation of calcium-mediated signaling;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051251|positive regulation of lymphocyte activation;GO:0051712|positive regulation of killing of cells of other organism;GO:0060267|positive regulation of respiratory burst;GO:0061760|antifungal innate immune response;GO:0070884|regulation of calcineurin-NFAT signaling cascade;GO:0071226|cellular response to molecule of fungal origin;GO:0071639|positive regulation of monocyte chemotactic protein-1 production;GO:0090303|positive regulation of wound healing;GO:1900017|positive regulation of cytokine production involved in inflammatory response;GO:1903431|positive regulation of cell maturation;GO:2000318|positive regulation of T-helper 17 type immune response;","GO:0005737|cytoplasm;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0001872|(1->3)-beta-D-glucan binding;GO:0030246|carbohydrate binding;GO:0038187|pattern recognition receptor activity;GO:0042802|identical protein binding;","K10074","CLEC7A, DECTIN1, CD369; C-type lectin domain family 7 member A"]
["ENSRNOG00000015773",161,13.36729234,32,2.058574022,6.493471793,2.698990034,{"v":2.23811e-29,"d":"2.24E-29"},{"v":1.16064e-28,"d":"1.16E-28"},"up","yes","Il21r","protein_coding","chr1:180168097-180195522:+","gi|60223063|ref|NP_001012487.1|",2367,0,"interleukin-21 receptor precursor [Rattus norvegicus]","gi|672038437|ref|XM_006230262.2|",1741,0,"PREDICTED: Rattus norvegicus interleukin 21 receptor (Il21r), transcript variant X2, mRNA","Q9JHX3",809,0,"Interleukin-21 receptor",".",".",".",".","pfam01108","Tissue_fac","Tissue factor. This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.","GO:0008150|biological_process;GO:0019221|cytokine-mediated signaling pathway;","GO:0005575|cellular_component;GO:0016020|membrane;","GO:0003674|molecular_function;GO:0004888|transmembrane signaling receptor activity;GO:0004896|cytokine receptor activity;","K05075","IL21R, CD360; interleukin 21 receptor"]
["ENSRNOG00000049976",291,24.16075821,117,7.526661268,3.210023323,1.68258378,{"v":2.37146E-29,"d":"2.37E-29"},{"v":1.2278E-28,"d":"1.23E-28"},"up","yes","Gzmbl2","protein_coding","chr15:30173603-30346814:-","gi|119851007|gb|AAI27476.1|",1175,{"v":3e-154,"d":"3.00E-154"},"Gzmb protein [Rattus norvegicus]","gi|119851006|gb|BC127475.1|",2052,0,"Rattus norvegicus granzyme B, mRNA (cDNA clone MGC:156565 IMAGE:7124652), complete cds","P18291",364,{"v":1E-119,"d":"1.00E-119"},"Granzyme B","mlr3307",53.1,1e-06,"COG5640","pfam00089","Trypsin","Trypsin.","GO:0001913|T cell mediated cytotoxicity;GO:0006508|proteolysis;GO:0006915|apoptotic process;GO:0010942|positive regulation of cell death;GO:0017148|negative regulation of translation;GO:0019835|cytolysis;GO:0042267|natural killer cell mediated cytotoxicity;GO:0051603|proteolysis involved in cellular protein catabolic process;GO:0060545|positive regulation of necroptotic process;GO:0070269|pyroptosis;","GO:0005576|extracellular region;GO:0005737|cytoplasm;GO:0005769|early endosome;GO:0043231|intracellular membrane-bounded organelle;GO:0044194|cytolytic granule;","GO:0004252|serine-type endopeptidase activity;GO:0005515|protein binding;GO:0008236|serine-type peptidase activity;","K01353","GZMB; granzyme B [EC:3.4.21.79]"]
["ENSRNOG00000016712",625,51.89166283,397,25.53918396,2.031844984,1.022790339,{"v":2.77602e-29,"d":"2.78E-29"},{"v":1.43262e-28,"d":"1.43E-28"},"up","yes","Lhcgr","protein_coding","chr6:5661871-5724521:+","gi|6981160|ref|NP_037110.1|",3342,0,"lutropin-choriogonadotropic hormone receptor precursor [Rattus norvegicus]","gi|6981159|ref|NM_012978.1|",2670,0,"Rattus norvegicus luteinizing hormone/choriogonadotropin receptor (Lhcgr), mRNA","P16235",1291,0,"Lutropin-choriogonadotropic hormone receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001541|ovarian follicle development;GO:0006622|protein targeting to lysosome;GO:0007188|adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007190|activation of adenylate cyclase activity;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007283|spermatogenesis;GO:0007417|central nervous system development;GO:0008584|male gonad development;GO:0008585|female gonad development;GO:0009410|response to xenobiotic stimulus;GO:0009755|hormone-mediated signaling pathway;GO:0010524|positive regulation of calcium ion transport into cytosol;GO:0022602|ovulation cycle process;GO:0032962|positive regulation of inositol trisphosphate biosynthetic process;GO:0034699|response to luteinizing hormone;GO:0042700|luteinizing hormone signaling pathway;GO:0046544|development of secondary male sexual characteristics;GO:0046886|positive regulation of hormone biosynthetic process;GO:0050482|arachidonic acid secretion;GO:0050810|regulation of steroid biosynthetic process;GO:0050850|positive regulation of calcium-mediated signaling;GO:0050890|cognition;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;GO:0060065|uterus development;GO:0071371|cellular response to gonadotropin stimulus;GO:0071373|cellular response to luteinizing hormone stimulus;GO:0072520|seminiferous tubule development;GO:0090030|regulation of steroid hormone biosynthetic process;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0005768|endosome;GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0031233|intrinsic component of external side of plasma membrane;GO:0043235|receptor complex;","GO:0004964|luteinizing hormone receptor activity;GO:0008528|G protein-coupled peptide receptor activity;GO:0017046|peptide hormone binding;GO:0035472|choriogonadotropin hormone receptor activity;GO:0038106|choriogonadotropin hormone binding;GO:0042802|identical protein binding;GO:0051117|ATPase binding;","K04248","LHCGR; lutropin-choriogonadotropic hormone receptor"]
["ENSRNOG00000001270",227,18.84705194,73,4.696121987,4.01332248,2.004797085,{"v":4.36701e-29,"d":"4.37E-29"},{"v":2.24102e-28,"d":"2.24E-28"},"up","yes","Hvcn1","protein_coding","chr12:34335190-34370141:-","gi|564315319|ref|XP_006221413.1|",1175,{"v":7e-146,"d":"7.00E-146"},"PREDICTED: voltage-gated hydrogen channel 1 isoform X2 [Rattus norvegicus]","gi|672026745|ref|XM_006221351.2|",1882,0,"PREDICTED: Rattus norvegicus hydrogen voltage-gated channel 1 (Hvcn1), transcript variant X2, mRNA","Q3U2S8",399,{"v":3e-126,"d":"3.00E-126"},"Voltage-gated hydrogen channel 1",".",".",".",".","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0009268|response to pH;GO:0010043|response to zinc ion;GO:0032930|positive regulation of superoxide anion generation;GO:0051453|regulation of intracellular pH;GO:0071294|cellular response to zinc ion;GO:0071467|cellular response to pH;GO:1902600|proton transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;","GO:0022843|voltage-gated cation channel activity;GO:0030171|voltage-gated proton channel activity;GO:0042802|identical protein binding;","K22644","HVCN1, HV1; voltage-gated hydrogen channel 1"]
["ENSRNOG00000031515",138,11.45767915,21,1.350939202,8.48126928,3.08428019,{"v":8.32575e-29,"d":"8.33E-29"},{"v":4.22506e-28,"d":"4.23E-28"},"up","yes","Klra2","protein_coding","chr4:164909969-164985338:-","gi|57222300|ref|NP_001009486.1|",1309,{"v":2E-167,"d":"2.00E-167"},"killer cell lectin-like receptor 2 [Rattus norvegicus]","gi|55250451|gb|BC085917.1|",3540,0,"Rattus norvegicus killer cell lectin-like receptor, subfamily A, member 2, mRNA (cDNA clone MGC:94821 IMAGE:7108565), complete cds","Q60660",283,{"v":4e-85,"d":"4.00E-85"},"Killer cell lectin-like receptor 2",".",".",".",".","pfam08391","Ly49","Ly49-like protein, N-terminal region. The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).","GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;",".","."]
["ENSRNOG00000001757",133,11.04254585,19,1.222278326,9.034395538,3.175428078,{"v":1.5745e-28,"d":"1.57E-28"},{"v":7.95223e-28,"d":"7.95E-28"},"up","yes","Tm4sf19","protein_coding","chr11:68371647-68384591:-","gi|157786784|ref|NP_001099343.1|",791,{"v":4e-96,"d":"4.00E-96"},"transmembrane 4 L6 family member 19 [Rattus norvegicus]","gi|157786783|ref|NM_001105873.1|",766,0,"Rattus norvegicus transmembrane 4 L six family member 19 (Tm4sf19), mRNA","Q96DZ7",221,{"v":9e-65,"d":"9.00E-65"},"Transmembrane 4 L6 family member 19",".",".",".",".","pfam05805","L6_membrane","L6 membrane protein. This family consists of several eukaryotic L6 membrane proteins. L6, IL-TMP, and TM4SF5 are cell surface proteins predicted to have four transmembrane domains. Previous sequence analysis led to their assignment as members of the tetraspanin superfamily it has now been found that that they are not significantly related to genuine tetraspanins, but instead constitute their own L6 family. Several members of this family have been implicated in human cancer.",".","GO:0016021|integral component of membrane;",".","K24922","TM4SF19; transmembrane 4 L6 family member 19"]
["ENSRNOG00000010475",510,42.34359687,300,19.29913146,2.194067488,1.133607903,{"v":2.63328E-28,"d":"2.63E-28"},{"v":1.32162e-27,"d":"1.32E-27"},"up","yes","Casp3","protein_coding","chr16:45662910-45684648:-","gi|6978605|ref|NP_037054.1|",1498,0,"caspase-3 [Rattus norvegicus]","gi|672080148|ref|XM_006253130.2|",2421,0,"PREDICTED: Rattus norvegicus caspase 3 (Casp3), transcript variant X1, mRNA","P55213",581,0,"Caspase-3",".",".",".",".","pfam00656","Peptidase_C14","Caspase domain.","GO:0001554|luteolysis;GO:0001666|response to hypoxia;GO:0001782|B cell homeostasis;GO:0006508|proteolysis;GO:0006915|apoptotic process;GO:0006974|cellular response to DNA damage stimulus;GO:0007413|axonal fasciculation;GO:0007507|heart development;GO:0007605|sensory perception of sound;GO:0007611|learning or memory;GO:0008627|intrinsic apoptotic signaling pathway in response to osmotic stress;GO:0009410|response to xenobiotic stimulus;GO:0009411|response to UV;GO:0009611|response to wounding;GO:0009749|response to glucose;GO:0010033|response to organic substance;GO:0010038|response to metal ion;GO:0010165|response to X-ray;GO:0010996|response to auditory stimulus;GO:0014070|response to organic cyclic compound;GO:0016485|protein processing;GO:0021766|hippocampus development;GO:0030182|neuron differentiation;GO:0030216|keratinocyte differentiation;GO:0030218|erythrocyte differentiation;GO:0030889|negative regulation of B cell proliferation;GO:0031647|regulation of protein stability;GO:0032025|response to cobalt ion;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0034349|glial cell apoptotic process;GO:0035094|response to nicotine;GO:0035556|intracellular signal transduction;GO:0042060|wound healing;GO:0042542|response to hydrogen peroxide;GO:0043029|T cell homeostasis;GO:0043065|positive regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0043200|response to amino acid;GO:0043525|positive regulation of neuron apoptotic process;GO:0045165|cell fate commitment;GO:0045736|negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045786|negative regulation of cell cycle;GO:0046007|negative regulation of activated T cell proliferation;GO:0046677|response to antibiotic;GO:0048011|neurotrophin TRK receptor signaling pathway;GO:0051146|striated muscle cell differentiation;GO:0051384|response to glucocorticoid;GO:0051402|neuron apoptotic process;GO:0061713|anterior neural tube closure;GO:0071310|cellular response to organic substance;GO:0071407|cellular response to organic cyclic compound;GO:0071887|leukocyte apoptotic process;GO:0072734|cellular response to staurosporine;GO:0097194|execution phase of apoptosis;GO:1902004|positive regulation of amyloid-beta formation;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0031264|death-inducing signaling complex;GO:0043025|neuronal cell body;GO:0045121|membrane raft;","GO:0002020|protease binding;GO:0004175|endopeptidase activity;GO:0004190|aspartic-type endopeptidase activity;GO:0004197|cysteine-type endopeptidase activity;GO:0004861|cyclin-dependent protein serine/threonine kinase inhibitor activity;GO:0005123|death receptor binding;GO:0005515|protein binding;GO:0008233|peptidase activity;GO:0008234|cysteine-type peptidase activity;GO:0016005|phospholipase A2 activator activity;GO:0044877|protein-containing complex binding;GO:0097153|cysteine-type endopeptidase activity involved in apoptotic process;GO:0097199|cysteine-type endopeptidase activity involved in apoptotic signaling pathway;GO:0097200|cysteine-type endopeptidase activity involved in execution phase of apoptosis;","K02187","CASP3; caspase 3 [EC:3.4.22.56]"]
["ENSRNOG00000013294",143,11.87281246,25,1.608260955,7.382391782,2.884088303,{"v":5.04558e-28,"d":"5.05E-28"},{"v":2.5087e-27,"d":"2.51E-27"},"up","yes","Sh2d2a","protein_coding","chr2:173312253-173318810:+","gi|57527970|ref|NP_997488.2|",1795,0,"SH2 domain-containing protein 2A [Rattus norvegicus]","gi|57527969|ref|NM_207605.3|",1562,0,"Rattus norvegicus SH2 domain containing 2A (Sh2d2a), mRNA","Q9QXK9",587,0,"SH2 domain-containing protein 2A",".",".",".",".","pfam00017","SH2","SH2 domain.","GO:0008283|cell proliferation;",".",".","K08273","SH2D2A, VRAP; SH2 domain-containing protein 2A"]
["ENSRNOG00000006963",196,16.27322546,56,3.602504538,4.517197769,2.175428078,{"v":6.08526E-28,"d":"6.09E-28"},{"v":3.0186e-27,"d":"3.02E-27"},"up","yes","Ctse","protein_coding","chr13:43092128-43114502:+","gi|564380459|ref|XP_006249810.1|",2063,0,"PREDICTED: cathepsin E isoform X1 [Rattus norvegicus]","gi|672073643|ref|XM_006249748.2|",1940,0,"PREDICTED: Rattus norvegicus cathepsin E (Ctse), transcript variant X1, mRNA","P16228",798,0,"Cathepsin E",".",".",".",".","pfam00026","Asp","Eukaryotic aspartyl protease. Aspartyl (acid) proteases include pepsins, cathepsins, and renins. Two-domain structure, probably arising from ancestral duplication. This family does not include the retroviral nor retrotransposon proteases (pfam00077), which are much smaller and appear to be homologous to a single domain of the eukaryotic asp proteases.","GO:0006508|proteolysis;GO:0016540|protein autoprocessing;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;","GO:0005768|endosome;","GO:0004190|aspartic-type endopeptidase activity;GO:0008233|peptidase activity;GO:0042802|identical protein binding;","K01382","CTSE; cathepsin E [EC:3.4.23.34]"]
["ENSRNOG00000001874",353,29.30841117,170,10.93617449,2.679950945,1.422206593,{"v":6.31843e-28,"d":"6.32E-28"},{"v":3.13184e-27,"d":"3.13E-27"},"up","yes","Slc7a4","protein_coding","chr11:83435211-83438881:+","gi|157819067|ref|NP_001100548.1|",2615,0,"cationic amino acid transporter 4 [Rattus norvegicus]","gi|672071714|ref|XM_006248697.2|",2465,0,"PREDICTED: Rattus norvegicus solute carrier family 7, member 4 (Slc7a4), transcript variant X4, mRNA","Q8BLQ7",991,0,"Cationic amino acid transporter 4","BS_yfnA",183,{"v":3E-49,"d":"3.00E-49"},"COG0531","pfam13520","AA_permease_2","Amino acid permease.","GO:0003333|amino acid transmembrane transport;GO:0006865|amino acid transport;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0015171|amino acid transmembrane transporter activity;","K13866","SLC7A4; solute carrier family 7 (cationic amino acid transporter), member 4"]
["ENSRNOG00000023122",140,11.62373247,24,1.543930516,7.528662948,2.912393672,{"v":1.00899e-27,"d":"1.01E-27"},{"v":4.97043e-27,"d":"4.97E-27"},"up","yes","ENSRNOG00000023122","protein_coding","chr7:109248942-109253716:-","gi|672022080|ref|XP_008774731.1|",1297,{"v":5e-173,"d":"5.00E-173"},"PREDICTED: apolipoprotein L3-like isoform X2 [Rattus norvegicus]","gi|672059735|ref|XM_006241949.2|",1538,0,"PREDICTED: Rattus norvegicus apolipoprotein L 11a (Apol11a), transcript variant X3, mRNA","O95236",144,{"v":2e-36,"d":"2.00E-36"},"Apolipoprotein L3",".",".",".",".","pfam05461","ApoL","Apolipoprotein L. Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.","GO:0006869|lipid transport;GO:0042157|lipoprotein metabolic process;","GO:0005576|extracellular region;",".","K14480","APOL; apolipoprotein L"]
["ENSRNOG00000061895",231,19.17915858,81,5.210765493,3.680679664,1.879972195,{"v":2.75048e-27,"d":"2.75E-27"},{"v":1.33944e-26,"d":"1.34E-26"},"up","yes","Ly49si1","protein_coding","chr4:163586930-163827002:-","gi|672051541|ref|XP_008761656.1|",1443,0,"PREDICTED: T-cell surface glycoprotein YE1/48-like isoform X2 [Rattus norvegicus]","gi|672051196|ref|XM_008763316.1|",934,0,"PREDICTED: Rattus norvegicus immunoreceptor Ly49si1 (Ly49si1), transcript variant X5, mRNA","P20937",326,{"v":7e-108,"d":"7.00E-108"},"T-cell surface glycoprotein YE1/48",".",".",".",".","pfam08391","Ly49","Ly49-like protein, N-terminal region. The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000065128",96,7.97055941,4,0.257321753,30.97507041,4.953035657,{"v":3.83209E-27,"d":"3.83E-27"},{"v":1.85627e-26,"d":"1.86E-26"},"up","yes","Naip5","protein_coding","chr2:31557817-31608634:-","gi|109464318|ref|XP_226743.4|",7285,0,"PREDICTED: baculoviral IAP repeat-containing protein 1e-like [Rattus norvegicus]","gi|672041321|ref|XM_226743.6|",5828,0,"PREDICTED: Rattus norvegicus NLR family, apoptosis inhibitory protein 5 (Naip5), transcript variant X1, mRNA","Q9R016",2324,0,"Baculoviral IAP repeat-containing protein 1e",".",".",".",".","pfam05729","NACHT","NACHT domain. This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.",".",".",".",".","."]
["ENSRNOG00000065666",225,18.68099862,78,5.017774178,3.722965194,1.896452129,{"v":6.46186e-27,"d":"6.46E-27"},{"v":3.11128e-26,"d":"3.11E-26"},"up","yes","ENSRNOG00000065666","protein_coding","chr4:31319843-31342307:-","gi|672018006|ref|XP_008773888.1|",6607,0,"PREDICTED: LOW QUALITY PROTEIN: sterile alpha motif domain-containing protein 9-like [Rattus norvegicus]","gi|672018005|ref|XM_008775666.1|",5138,0,"PREDICTED: Rattus norvegicus similar to sterile alpha motif domain containing 9-like (LOC684193), mRNA","Q69Z37",2094,0,"Sterile alpha motif domain-containing protein 9-like",".",".",".",".","pfam02994","Transposase_22","L1 transposable element.",".",".",".",".","."]
["ENSRNOG00000049590",137,11.37465249,24,1.543930516,7.367334456,2.881142738,{"v":6.8442e-27,"d":"6.84E-27"},{"v":3.29042E-26,"d":"3.29E-26"},"up","yes","RT1-M2","protein_coding","chr20:978935-981723:+","gi|48843735|ref|NP_001001717.1|",1588,0,"RT1 class Ib, locus M2 precursor [Rattus norvegicus]","gi|672085524|ref|XM_008772690.1|",1160,0,"PREDICTED: Rattus norvegicus RT1 class Ib, locus M2 (RT1-M2), transcript variant X1, mRNA","P01902",402,{"v":8e-135,"d":"8.00E-135"},"H-2 class I histocompatibility antigen, K-D alpha chain",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.","GO:0001916|positive regulation of T cell mediated cytotoxicity;GO:0002476|antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002486|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0006955|immune response;","GO:0005615|extracellular space;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0005102|signaling receptor binding;GO:0042605|peptide antigen binding;","K06751","MHC1; MHC class I antigen"]
["ENSRNOG00000066181",343,28.47814456,168,10.80751362,2.635032032,1.3978205,{"v":1.59882e-26,"d":"1.60E-26"},{"v":7.62343e-26,"d":"7.62E-26"},"up","yes","RT1-CE14","protein_coding","chr20:3297196-3305134:-","gi|77404172|ref|NP_001029157.1|",1497,0,"RT1 class I, locus CE14 isoform 2 [Rattus norvegicus]","gi|46237639|emb|BX883047.1|",4436,0,"Rattus norvegicus chromosome 20, major histocompatibility complex, assembled from 40 BACs, strain Brown Norway (BN/ssNHsd), RT1n haplotype; segment 6/11","P16391",499,{"v":7E-159,"d":"7.00E-159"},"RT1 class I histocompatibility antigen, AA alpha chain",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.",".",".",".",".","."]
["ENSRNOG00000066615",91,7.555426108,2,0.128660876,58.72357099,5.875867796,{"v":2.38176e-26,"d":"2.38E-26"},{"v":1.13313e-25,"d":"1.13E-25"},"up","yes","ENSRNOG00000066615","protein_coding","chr4:162690665-162705515:+","gi|149029577|gb|EDL84768.1|",595,{"v":1e-65,"d":"1.00E-65"},"rCG23031 [Rattus norvegicus]","gi|14318383|gb|AC087041.2|",469,0,"Rattus norvegicus strain Brown Norway clone RP31-188L2, complete sequence",".",".",".",".",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type",".",".",".",".","."]
["ENSRNOG00000011471",175,14.52966559,47,3.023530595,4.805529541,2.264695416,{"v":2.57292E-26,"d":"2.57E-26"},{"v":1.22316E-25,"d":"1.22E-25"},"up","yes","Fgf9","protein_coding","chr15:32210074-32253309:+","gi|74177316|dbj|BAE34566.1|",611,{"v":5e-84,"d":"5.00E-84"},"unnamed protein product [Mus musculus]","gi|755547794|ref|XM_006518554.2|",1348,0,"PREDICTED: Mus musculus fibroblast growth factor 9 (Fgf9), transcript variant X2, mRNA","P36364",240,{"v":9e-71,"d":"9.00E-71"},"Fibroblast growth factor 9",".",".",".",".","pfam00167","FGF","Fibroblast growth factor. Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide range of contexts. They are found in a wide range of organisms, from nematodes to humans. Most share an internal core region of high similarity, conserved residues in which are involved in binding with their receptors. On binding, they cause dimerization of their tyrosine kinase receptors leading to intracellular signalling. There are currently four known tyrosine kinase receptors for fibroblast growth factors. These receptors can each bind several different members of this family. Members of this family have a beta trefoil structure. Most have N-terminal signal peptides and are secreted. A few lack signal sequences but are secreted anyway; still others also lack the signal peptide but are found on the cell surface and within the extracellular matrix. A third group remain intracellular. They have central roles in development, regulating cell proliferation, migration and differentiation. On the other hand, they are important in tissue repair following injury in adult organisms.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001525|angiogenesis;GO:0001649|osteoblast differentiation;GO:0001654|eye development;GO:0001934|positive regulation of protein phosphorylation;GO:0002053|positive regulation of mesenchymal cell proliferation;GO:0002062|chondrocyte differentiation;GO:0006606|protein import into nucleus;GO:0007267|cell-cell signaling;GO:0008284|positive regulation of cell proliferation;GO:0008543|fibroblast growth factor receptor signaling pathway;GO:0008584|male gonad development;GO:0009887|animal organ morphogenesis;GO:0010628|positive regulation of gene expression;GO:0021762|substantia nigra development;GO:0030154|cell differentiation;GO:0030178|negative regulation of Wnt signaling pathway;GO:0030238|male sex determination;GO:0030324|lung development;GO:0030326|embryonic limb morphogenesis;GO:0030334|regulation of cell migration;GO:0030949|positive regulation of vascular endothelial growth factor receptor signaling pathway;GO:0032927|positive regulation of activin receptor signaling pathway;GO:0042472|inner ear morphogenesis;GO:0043410|positive regulation of MAPK cascade;GO:0045880|positive regulation of smoothened signaling pathway;GO:0048505|regulation of timing of cell differentiation;GO:0048566|embryonic digestive tract development;GO:0048706|embryonic skeletal system development;GO:0050679|positive regulation of epithelial cell proliferation;GO:0051781|positive regulation of cell division;GO:0060045|positive regulation of cardiac muscle cell proliferation;GO:0060484|lung-associated mesenchyme development;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:1904707|positive regulation of vascular smooth muscle cell proliferation;GO:1904754|positive regulation of vascular associated smooth muscle cell migration;GO:1905931|negative regulation of vascular smooth muscle cell differentiation involved in phenotypic switching;","GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0005737|cytoplasm;","GO:0005104|fibroblast growth factor receptor binding;GO:0008083|growth factor activity;GO:0008201|heparin binding;","K04358","FGF; fibroblast growth factor"]
["ENSRNOG00000013408",200,16.6053321,63,4.052817606,4.097231536,2.034649422,{"v":2.71904e-26,"d":"2.72E-26"},{"v":1.28975E-25,"d":"1.29E-25"},"up","yes","Npas2","protein_coding","chr9:41463830-41642320:+","gi|210032658|ref|NP_001101684.2|",3666,0,"neuronal PAS domain-containing protein 2 [Rattus norvegicus]","gi|210032657|ref|NM_001108214.2|",4273,0,"Rattus norvegicus neuronal PAS domain protein 2 (Npas2), mRNA","P97460",1357,0,"Neuronal PAS domain-containing protein 2",".",".",".",".","pfam14598","PAS_11","PAS domain. This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).","GO:0006357|regulation of transcription by RNA polymerase II;GO:0007623|circadian rhythm;GO:0009410|response to xenobiotic stimulus;GO:0032922|circadian regulation of gene expression;GO:0042745|circadian sleep/wake cycle;GO:0042752|regulation of circadian rhythm;GO:0045475|locomotor rhythm;GO:0045739|positive regulation of DNA repair;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051775|response to redox state;GO:0060548|negative regulation of cell death;GO:2000987|positive regulation of behavioral fear response;GO:2001020|regulation of response to DNA damage stimulus;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005829|cytosol;GO:1990513|CLOCK-BMAL transcription complex;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0046983|protein dimerization activity;GO:0051879|Hsp90 protein binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09026","NPAS2; neuronal PAS domain-containing protein 2"]
["ENSRNOG00000006167",165,13.69939899,41,2.637547966,5.193990466,2.376843366,{"v":2.72986e-26,"d":"2.73E-26"},{"v":1.29392E-25,"d":"1.29E-25"},"up","yes","Rasal3","protein_coding","chr7:11396090-11411465:-","gi|564358455|ref|XP_006241121.1|",4827,0,"PREDICTED: RAS protein activator like-3 isoform X1 [Rattus norvegicus]","gi|197381463|ref|NM_001134562.1|",3922,0,"Rattus norvegicus RAS protein activator like 3 (Rasal3), mRNA","Q8C2K5",1673,0,"RAS protein activator like-3",".",".",".",".","pfam00616","RasGAP","GTPase-activator protein for Ras-like GTPase. All alpha-helical domain that accelerates the GTPase activity of Ras, thereby \"switching\" it into an \"off\" position.","GO:0007165|signal transduction;GO:0043087|regulation of GTPase activity;GO:0046580|negative regulation of Ras protein signal transduction;GO:0051142|positive regulation of NK T cell proliferation;","GO:0005737|cytoplasm;GO:0098562|cytoplasmic side of membrane;","GO:0042802|identical protein binding;","K17634","RASAL3; RAS protein activator-like 3"]
["ENSRNOG00000015366",153,12.70307906,34,2.187234898,5.807825703,2.537998158,{"v":2.75407e-26,"d":"2.75E-26"},{"v":1.30443E-25,"d":"1.30E-25"},"up","yes","Neurl3","protein_coding","chr9:38494489-38502649:-","gi|62078933|ref|NP_001014122.1|",1346,0,"E3 ubiquitin-protein ligase NEURL3 [Rattus norvegicus]","gi|298891378|emb|FQ227363.1|",1424,0,"Rattus norvegicus TL0AEA13YJ20 mRNA sequence","Q5M870",523,0,"E3 ubiquitin-protein ligase NEURL3",".",".",".",".","pfam07177","Neuralized","Neuralized. This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.","GO:0016567|protein ubiquitination;",".","GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;","K15689","NEURL3, LINCR; E3 ubiquitin-protein ligase NEURL3 [EC:2.3.2.27]"]
["ENSRNOG00000053891",95,7.88753275,5,0.321652191,24.52193075,4.61600067,{"v":2.8236e-26,"d":"2.82E-26"},{"v":1.33538E-25,"d":"1.34E-25"},"up","yes","Phf11","protein_coding","chr15:33390292-33413009:-","gi|66730368|ref|NP_001019443.1|",1503,0,"PHD finger protein 11 [Rattus norvegicus]","gi|66730367|ref|NM_001024272.1|",1453,0,"Rattus norvegicus PHD finger protein 11 (Phf11), mRNA","Q5I0E2",583,0,"PHD finger protein 11",".",".",".",".","pfam13771","zf-HC5HC2H","PHD-like zinc-binding domain. The members of this family are annotated as containing PHD domain, but the zinc-binding region here is not typical of PHD domains. The conformation here is a well-conserved cysteine-histidine rich region spanning 90 residues, where the Cys and His are arranged as HxxC(31)CxxC(6)CxxCxxxxCxxxxHxxC (21)CxxH.",".","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0031965|nuclear membrane;","GO:0046872|metal ion binding;",".","."]
["ENSRNOG00000018488",186,15.44295886,54,3.473843662,4.445496217,2.152344465,{"v":2.86039e-26,"d":"2.86E-26"},{"v":1.35178e-25,"d":"1.35E-25"},"up","yes","Cd40","protein_coding","chr3:153790449-153805534:+","gi|564344249|ref|XP_006235573.1|",1553,0,"PREDICTED: tumor necrosis factor receptor superfamily member 5 isoform X1 [Rattus norvegicus]","gi|672047962|ref|XM_006235511.2|",1565,0,"PREDICTED: Rattus norvegicus CD40 molecule, TNF receptor superfamily member 5 (Cd40), transcript variant X1, mRNA","P27512",469,{"v":3E-162,"d":"3.00E-162"},"Tumor necrosis factor receptor superfamily member 5",".",".",".",".","pfam00020","TNFR_c6","TNFR/NGFR cysteine-rich region.","GO:0001934|positive regulation of protein phosphorylation;GO:0002637|regulation of immunoglobulin production;GO:0002768|immune response-regulating cell surface receptor signaling pathway;GO:0006874|cellular calcium ion homeostasis;GO:0006954|inflammatory response;GO:0009617|response to bacterium;GO:0019724|B cell mediated immunity;GO:0023035|CD40 signaling pathway;GO:0030890|positive regulation of B cell proliferation;GO:0031667|response to nutrient levels;GO:0032735|positive regulation of interleukin-12 production;GO:0033590|response to cobalamin;GO:0034341|response to interferon-gamma;GO:0035666|TRIF-dependent toll-like receptor signaling pathway;GO:0036018|cellular response to erythropoietin;GO:0042113|B cell activation;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0042832|defense response to protozoan;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043406|positive regulation of MAP kinase activity;GO:0043491|protein kinase B signaling;GO:0043536|positive regulation of blood vessel endothelial cell migration;GO:0043547|positive regulation of GTPase activity;GO:0045766|positive regulation of angiogenesis;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048304|positive regulation of isotype switching to IgG isotypes;GO:0050776|regulation of immune response;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051607|defense response to virus;GO:0071222|cellular response to lipopolysaccharide;GO:0071260|cellular response to mechanical stimulus;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0090037|positive regulation of protein kinase C signaling;GO:1901652|response to peptide;GO:2000353|positive regulation of endothelial cell apoptotic process;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0035631|CD40 receptor complex;GO:0043025|neuronal cell body;GO:0043196|varicosity;GO:0043231|intracellular membrane-bounded organelle;","GO:0003823|antigen binding;GO:0019899|enzyme binding;GO:0019904|protein domain specific binding;GO:0031625|ubiquitin protein ligase binding;GO:0038023|signaling receptor activity;","K03160","TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5"]
["ENSRNOG00000061403",357,29.64051781,181,11.64380931,2.545603163,1.348007533,{"v":3.81653e-26,"d":"3.82E-26"},{"v":1.797E-25,"d":"1.80E-25"},"up","yes","AABR07039446.2","protein_coding","chrX:71220367-71242376:+","gi|564322995|ref|XP_006227480.1|",4726,0,"PREDICTED: toll-like receptor 13 [Rattus norvegicus]","gi|672032506|ref|XM_006227419.2|",3814,0,"PREDICTED: Rattus norvegicus toll-like receptor 13 (Tlr13), transcript variant X2, mRNA","Q6R5N8",1672,0,"Toll-like receptor 13","SPBC19C7.03_1",61.2,2E-8,"COG4886","pfam01582","TIR","TIR domain. The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.",".",".",".",".","."]
["ENSRNOG00000022012",103,8.551746034,9,0.578973944,14.77051969,3.884648682,{"v":5.1562e-26,"d":"5.16E-26"},{"v":2.41533E-25,"d":"2.42E-25"},"up","yes","Tnfrsf18","protein_coding","chr5:166618969-166622353:+","gi|149024859|gb|EDL81356.1|",1459,0,"similar to tumor necrosis factor receptor superfamily, member 18, isoform CRA_b [Rattus norvegicus]","gi|672055010|ref|XM_008764373.1|",1405,0,"PREDICTED: Rattus norvegicus tumor necrosis factor receptor superfamily, member 18 (Tnfrsf18), transcript variant X1, mRNA","O35714",390,{"v":6e-131,"d":"6.00E-131"},"Tumor necrosis factor receptor superfamily member 18",".",".",".",".","pfam07562","NCD3G","Nine Cysteines Domain of family 3 GPCR. This conserved sequence contains several highly-conserved Cys residues that are predicted to form disulphide bridges. It is predicted to lie outside the cell membrane, tethered to the pfam00003 in several receptor proteins.","GO:0002687|positive regulation of leukocyte migration;GO:0033209|tumor necrosis factor-mediated signaling pathway;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0043066|negative regulation of apoptotic process;GO:0045785|positive regulation of cell adhesion;","GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;","GO:0005031|tumor necrosis factor-activated receptor activity;","K05154","TNFRSF18, GITR, CD357; tumor necrosis factor receptor superfamily member 18"]
["ENSRNOG00000008062",366,30.38775775,189,12.15845282,2.499311237,1.32153057,{"v":5.23009e-26,"d":"5.23E-26"},{"v":2.44815e-25,"d":"2.45E-25"},"up","yes","Dqx1","protein_coding","chr4:115563752-115572590:+","gi|157821145|ref|NP_001102877.1|",3331,0,"ATP-dependent RNA helicase DQX1 [Rattus norvegicus]","gi|157821144|ref|NM_001109407.1|",2606,0,"Rattus norvegicus DEAQ box RNA-dependent ATPase 1 (Dqx1), mRNA","Q924H9",1213,0,"ATP-dependent RNA helicase DQX1","SPBC16H5.10c",342,{"v":1e-103,"d":"1.00E-103"},"COG1643","pfam07717","OB_NTP_bind","Oligonucleotide/oligosaccharide-binding (OB)-fold. This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.",".","GO:0005622|intracellular;GO:0005681|spliceosomal complex;","GO:0003723|RNA binding;GO:0004386|helicase activity;GO:0005524|ATP binding;","K14433","DQX1; ATP-dependent RNA helicase DQX1 [EC:3.6.4.13]"]
["ENSRNOG00000020833",403,33.45974419,220,14.1526964,2.364195715,1.241349471,{"v":5.55936e-26,"d":"5.56E-26"},{"v":2.59847e-25,"d":"2.60E-25"},"up","yes","Cspg5","protein_coding","chr8:110220653-110234758:+","gi|41281651|ref|NP_598413.1|",2658,0,"chondroitin sulfate proteoglycan 5 isoform 2 precursor [Rattus norvegicus]","gi|41281650|ref|NM_133652.1|",1704,0,"Rattus norvegicus chondroitin sulfate proteoglycan 5 (Cspg5), transcript variant 2, mRNA","Q9ERQ6",1030,0,"Chondroitin sulfate proteoglycan 5",".",".",".",".","pfam06566","Chon_Sulph_att","Chondroitin sulphate attachment domain. This family represents the chondroitin sulphate attachment domain of vertebrate neural transmembrane proteoglycans that contain EGF modules. Evidence has been accumulated to support the idea that neural proteoglycans are involved in various cellular events including mitogenesis, differentiation, axonal outgrowth and synaptogenesis. This domain contains several potential sites of chondroitin sulphate attachment, as well as potential sites of N-linked glycosylation.","GO:0007010|cytoskeleton organization;GO:0007399|nervous system development;GO:0031103|axon regeneration;GO:0040008|regulation of growth;GO:0048858|cell projection morphogenesis;GO:0050804|modulation of chemical synaptic transmission;GO:0099550|trans-synaptic signaling, modulating synaptic transmission;GO:0106091|glial cell projection elongation;GO:1900026|positive regulation of substrate adhesion-dependent cell spreading;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0000139|Golgi membrane;GO:0005789|endoplasmic reticulum membrane;GO:0005794|Golgi apparatus;GO:0009986|cell surface;GO:0030660|Golgi-associated vesicle membrane;GO:0045202|synapse;GO:0098978|glutamatergic synapse;GO:0098982|GABA-ergic synapse;GO:0099055|integral component of postsynaptic membrane;","GO:0005515|protein binding;","K08116","CSPG5; chondroitin sulfate proteoglycan 5"]
["ENSRNOG00000069835",160,13.28426568,39,2.508887089,5.294883832,2.404599032,{"v":7.17517e-26,"d":"7.18E-26"},{"v":3.33907e-25,"d":"3.34E-25"},"up","yes","Oas1i","protein_coding","chr12:35624592-35636604:+","gi|57527337|ref|NP_001009680.1|",1808,0,"2 ' -5 ' oligoadenylate synthetase 1I [Rattus norvegicus]","gi|672073200|ref|XM_003751197.2|",1648,0,"PREDICTED: Rattus norvegicus 2'-5'-oligoadenylate synthase 1A-like (LOC100910735), mRNA","P11928",555,0,"2'-5'-oligoadenylate synthase 1A",".",".",".",".","pfam10421","OAS1_C","2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus. This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between 320 and 344 at the extreme C-terminal end. Oligoadenylate synthetases are antiviral enzymes that counteract vial attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesize 2'.5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication. This domain is often associated with NTP_transf_2 pfam01909.",".",".",".",".","."]
["ENSRNOG00000013547",98,8.136612731,7,0.450313067,18.06879108,4.175428078,{"v":7.28218e-26,"d":"7.28E-26"},{"v":3.3864e-25,"d":"3.39E-25"},"up","yes","Slc6a12","protein_coding","chr4:154585500-154603750:+","gi|8394200|ref|NP_059031.1|",2850,0,"sodium- and chloride-dependent betaine transporter [Rattus norvegicus]","gi|8394199|ref|NM_017335.1|",2375,0,"Rattus norvegicus solute carrier family 6 (neurotransmitter transporter), member 12 (Slc6a12), mRNA","P48056",1075,0,"Sodium- and chloride-dependent betaine transporter","VC2012",192,{"v":8e-52,"d":"8.00E-52"},"COG0733","pfam00209","SNF","Sodium:neurotransmitter symporter family.","GO:0006836|neurotransmitter transport;GO:0009992|cellular water homeostasis;GO:0010033|response to organic substance;GO:0015718|monocarboxylic acid transport;GO:0015812|gamma-aminobutyric acid transport;GO:0035725|sodium ion transmembrane transport;GO:0055085|transmembrane transport;GO:0071474|cellular hyperosmotic response;","GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;GO:0043005|neuron projection;","GO:0005332|gamma-aminobutyric acid:sodium symporter activity;GO:0008028|monocarboxylic acid transmembrane transporter activity;","K05045","SLC6A12, BGT1; solute carrier family 6 (neurotransmitter transporter, betaine/GABA) member 12"]
["ENSRNOG00000004839",168,13.94847897,44,2.83053928,4.927852111,2.30095896,{"v":8.6737e-26,"d":"8.67E-26"},{"v":4.01597E-25,"d":"4.02E-25"},"up","yes","B4galnt1","protein_coding","chr7:62988930-62996190:+","gi|672058861|ref|XP_008763641.1|",2623,0,"PREDICTED: beta-1,4 N-acetylgalactosaminyltransferase 1 isoform X1 [Rattus norvegicus]","gi|672058864|ref|XM_006241497.2|",2765,0,"PREDICTED: Rattus norvegicus beta-1,4-N-acetyl-galactosaminyl transferase 1 (B4galnt1), transcript variant X3, mRNA","Q10468",1011,0,"Beta-1,4 N-acetylgalactosaminyltransferase 1",".",".",".",".","pfam00535","Glycos_transf_2","Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.","GO:0001574|ganglioside biosynthetic process;GO:0006687|glycosphingolipid metabolic process;GO:0006688|glycosphingolipid biosynthetic process;GO:0007283|spermatogenesis;GO:0019915|lipid storage;GO:0030259|lipid glycosylation;","GO:0000139|Golgi membrane;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0030173|integral component of Golgi membrane;","GO:0003947|(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity;GO:0008376|acetylgalactosaminyltransferase activity;","K00725","B4GALNT1, GALGT; (N-Acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase [EC:2.4.1.92]"]
["ENSRNOG00000028273",163,13.53334567,41,2.637547966,5.131033006,2.359249306,{"v":8.85939e-26,"d":"8.86E-26"},{"v":4.09898e-25,"d":"4.10E-25"},"up","yes","Tmem150b","protein_coding","chr1:69125710-69141034:+","gi|157818985|ref|NP_001100946.1|",1072,{"v":1e-140,"d":"1.00E-140"},"transmembrane protein 150B [Rattus norvegicus]","gi|157818984|ref|NM_001107476.1|",1667,0,"Rattus norvegicus transmembrane protein 150B (Tmem150b), mRNA","Q8R218",379,{"v":3e-127,"d":"3.00E-127"},"Modulator of macroautophagy TMEM150B",".",".",".",".","pfam10277","Frag1","Frag1/DRAM/Sfk1 family. This family includes Frag1, DRAM and Sfk1 proteins. Frag1 (FGF receptor activating protein 1) is a protein that is conserved from fungi to humans. There are four potential iso-prenylation sites throughout the peptide, viz CILW, CIIW and CIGL. Frag1 is a membrane-spanning protein that is ubiquitously expressed in adult tissues suggesting an important cellular function. Dram is a family of proteins conserved from nematodes to humans with six hydrophobic transmembrane regions and an Endoplasmic Reticulum signal peptide. It is a lysosomal protein that induces macro-autophagy as an effector of p53-mediated death, where p53 is the tumor-suppressor gene that is frequently mutated in cancer. Expression of Dram is stress-induced. This region is also part of a family of small plasma membrane proteins, referred to as Sfk1, that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, thus allowing proper localisation of Stt4p to the actin cytoskeleton.",".","GO:0005887|integral component of plasma membrane;",".","K21846","TMEM150; transmembrane protein 150"]
["ENSRNOG00000021856",151,12.53702574,34,2.187234898,5.731906413,2.519015054,{"v":9.25837e-26,"d":"9.26E-26"},{"v":4.27738E-25,"d":"4.28E-25"},"up","yes","Lat2","protein_coding","chr12:22104219-22118288:+","gi|564378917|ref|XP_006249222.1|",843,{"v":3e-107,"d":"3.00E-107"},"PREDICTED: linker for activation of T-cells family member 2 isoform X1 [Rattus norvegicus]","gi|672072670|ref|XM_006249160.2|",1235,0,"PREDICTED: Rattus norvegicus linker for activation of T cells family, member 2 (Lat2), transcript variant X3, mRNA","Q8CGL2",328,{"v":1E-108,"d":"1.00E-108"},"Linker for activation of T-cells family member 2",".",".",".",".","pfam15402","Spc7_N","N-terminus of kinetochore NMS complex subunit Spc7.","GO:0002250|adaptive immune response;GO:0002764|immune response-regulating signaling pathway;GO:0019722|calcium-mediated signaling;GO:0035556|intracellular signal transduction;GO:0042113|B cell activation;GO:0043303|mast cell degranulation;GO:0050853|B cell receptor signaling pathway;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0045121|membrane raft;","GO:0042169|SH2 domain binding;",".","."]
["ENSRNOG00000019728",211,17.51862537,72,4.631791549,3.782256862,1.919247343,{"v":1.00199E-25,"d":"1.00E-25"},{"v":4.6192e-25,"d":"4.62E-25"},"up","yes","Itgam","protein_coding","chr1:182659000-182709503:+","gi|149067646|gb|EDM17198.1|",6066,0,"integrin alpha M [Rattus norvegicus]","gi|672038371|ref|XM_006230214.2|",4009,0,"PREDICTED: Rattus norvegicus integrin, alpha M (Itgam), transcript variant X1, mRNA","P05555",2066,0,"Integrin alpha-M",".",".",".",".","pfam08441","Integrin_alpha2","Integrin alpha. This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.","GO:0001774|microglial cell activation;GO:0001781|neutrophil apoptotic process;GO:0002523|leukocyte migration involved in inflammatory response;GO:0006898|receptor-mediated endocytosis;GO:0006909|phagocytosis;GO:0006911|phagocytosis, engulfment;GO:0007155|cell adhesion;GO:0007159|leukocyte cell-cell adhesion;GO:0007229|integrin-mediated signaling pathway;GO:0010668|ectodermal cell differentiation;GO:0014005|microglia development;GO:0030593|neutrophil chemotaxis;GO:0030900|forebrain development;GO:0032930|positive regulation of superoxide anion generation;GO:0034113|heterotypic cell-cell adhesion;GO:0043315|positive regulation of neutrophil degranulation;GO:0045123|cellular extravasation;GO:0045963|negative regulation of dopamine metabolic process;GO:0050798|activated T cell proliferation;GO:0060376|positive regulation of mast cell differentiation;GO:0061756|leukocyte adhesion to vascular endothelial cell;GO:0090314|positive regulation of protein targeting to membrane;GO:0097190|apoptotic signaling pathway;GO:0097242|amyloid-beta clearance;GO:0098609|cell-cell adhesion;GO:0110090|positive regulation of hippocampal neuron apoptotic process;GO:0150062|complement-mediated synapse pruning;GO:0150064|vertebrate eye-specific patterning;GO:1901216|positive regulation of neuron death;GO:1903223|positive regulation of oxidative stress-induced neuron death;GO:1904151|positive regulation of microglial cell mediated cytotoxicity;GO:1905114|cell surface receptor signaling pathway involved in cell-cell signaling;GO:2000363|positive regulation of prostaglandin-E synthase activity;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0008305|integrin complex;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0034688|integrin alphaM-beta2 complex;GO:0044853|plasma membrane raft;","GO:0001846|opsonin binding;GO:0001851|complement component C3b binding;GO:0008201|heparin binding;GO:0031072|heat shock protein binding;GO:0038024|cargo receptor activity;GO:0043395|heparan sulfate proteoglycan binding;GO:0044877|protein-containing complex binding;GO:0046872|metal ion binding;","K06461","ITGAM, CD11b; integrin alpha MK06461; K06594"]
["ENSRNOG00000007437",306,25.40615812,142,9.134922222,2.781212308,1.475713879,{"v":1.00937E-25,"d":"1.01E-25"},{"v":4.64987e-25,"d":"4.65E-25"},"up","yes","Irf5","protein_coding","chr4:58127640-58139267:+","gi|564346042|ref|XP_006236242.1|",2637,0,"PREDICTED: interferon regulatory factor 5 isoform X1 [Rattus norvegicus]","gi|672049100|ref|XM_006236180.2|",2942,0,"PREDICTED: Rattus norvegicus interferon regulatory factor 5 (Irf5), transcript variant X1, mRNA","P56477",904,0,"Interferon regulatory factor 5",".",".",".",".","pfam10401","IRF-3","Interferon-regulatory factor 3. This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1).  Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.","GO:0002376|immune system process;GO:0006357|regulation of transcription by RNA polymerase II;GO:0019221|cytokine-mediated signaling pathway;GO:0032481|positive regulation of type I interferon production;GO:0032494|response to peptidoglycan;GO:0032495|response to muramyl dipeptide;GO:0043065|positive regulation of apoptotic process;GO:0045087|innate immune response;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051607|defense response to virus;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0019901|protein kinase binding;GO:0042802|identical protein binding;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09446","IRF5; interferon regulatory factor 5"]
["ENSRNOG00000038835",196,16.27322546,62,3.988487167,4.080049598,2.02858669,{"v":1.04895e-25,"d":"1.05E-25"},{"v":4.82526e-25,"d":"4.83E-25"},"up","yes","Cd86","protein_coding","chr11:64163828-64200818:+","gi|11464989|ref|NP_064466.1|",1609,0,"T-lymphocyte activation antigen CD86 precursor [Rattus norvegicus]","gi|672071192|ref|XM_006248399.2|",1415,0,"PREDICTED: Rattus norvegicus CD86 molecule (Cd86), transcript variant X1, mRNA","P42082",399,{"v":1e-133,"d":"1.00E-133"},"T-lymphocyte activation antigen CD86",".",".",".",".","pfam08205","C2-set_2","CD80-like C2-set immunoglobulin domain. These domains belong to the immunoglobulin superfamily.","GO:0001878|response to yeast;GO:0002224|toll-like receptor signaling pathway;GO:0002309|T cell proliferation involved in immune response;GO:0002639|positive regulation of immunoglobulin production;GO:0002668|negative regulation of T cell anergy;GO:0006955|immune response;GO:0007166|cell surface receptor signaling pathway;GO:0007202|activation of phospholipase C activity;GO:0007568|aging;GO:0009410|response to xenobiotic stimulus;GO:0023035|CD40 signaling pathway;GO:0031295|T cell costimulation;GO:0032496|response to lipopolysaccharide;GO:0034138|toll-like receptor 3 signaling pathway;GO:0034341|response to interferon-gamma;GO:0042102|positive regulation of T cell proliferation;GO:0042104|positive regulation of activated T cell proliferation;GO:0042113|B cell activation;GO:0042130|negative regulation of T cell proliferation;GO:0043011|myeloid dendritic cell differentiation;GO:0051607|defense response to virus;GO:0071222|cellular response to lipopolysaccharide;GO:0071248|cellular response to metal ion;GO:0071345|cellular response to cytokine stimulus;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1990051|activation of protein kinase C activity;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0034451|centriolar satellite;GO:0043231|intracellular membrane-bounded organelle;GO:0070062|extracellular exosome;","GO:0005102|signaling receptor binding;","K05413","CD86; CD86 antigen"]
["ENSRNOG00000018509",122,10.12925258,19,1.222278326,8.287189892,3.05088298,{"v":2.05596E-25,"d":"2.06E-25"},{"v":9.39004e-25,"d":"9.39E-25"},"up","yes","Cx3cr1","protein_coding","chr8:119782595-119800014:-","gi|19424190|ref|NP_598218.1|",1527,0,"CX3C chemokine receptor 1 [Rattus norvegicus]","gi|672063562|ref|XM_008766668.1|",3337,0,"PREDICTED: Rattus norvegicus chemokine (C-X3-C motif) receptor 1 (Cx3cr1), transcript variant X1, mRNA","P35411",592,0,"CX3C chemokine receptor 1",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001774|microglial cell activation;GO:0002052|positive regulation of neuroblast proliferation;GO:0002250|adaptive immune response;GO:0002282|microglial cell activation involved in immune response;GO:0002881|negative regulation of chronic inflammatory response to non-antigenic stimulus;GO:0002931|response to ischemia;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007155|cell adhesion;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007420|brain development;GO:0007613|memory;GO:0016525|negative regulation of angiogenesis;GO:0019221|cytokine-mediated signaling pathway;GO:0019722|calcium-mediated signaling;GO:0021626|central nervous system maturation;GO:0021795|cerebral cortex cell migration;GO:0030336|negative regulation of cell migration;GO:0030595|leukocyte chemotaxis;GO:0032680|regulation of tumor necrosis factor production;GO:0032691|negative regulation of interleukin-1 beta production;GO:0035176|social behavior;GO:0035425|autocrine signaling;GO:0045428|regulation of nitric oxide biosynthetic process;GO:0045766|positive regulation of angiogenesis;GO:0048246|macrophage chemotaxis;GO:0048874|host-mediated regulation of intestinal microbiota composition;GO:0050769|positive regulation of neurogenesis;GO:0050804|modulation of chemical synaptic transmission;GO:0050901|leukocyte tethering or rolling;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051897|positive regulation of protein kinase B signaling;GO:0060074|synapse maturation;GO:0060326|cell chemotaxis;GO:0061760|antifungal innate immune response;GO:0070098|chemokine-mediated signaling pathway;GO:0071222|cellular response to lipopolysaccharide;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0090026|positive regulation of monocyte chemotaxis;GO:0098883|synapse pruning;GO:0110091|negative regulation of hippocampal neuron apoptotic process;GO:0150090|multiple spine synapse organization, single dendrite;GO:1900272|negative regulation of long-term synaptic potentiation;GO:1903721|positive regulation of I-kappaB phosphorylation;GO:1904141|positive regulation of microglial cell migration;GO:1904150|negative regulation of microglial cell mediated cytotoxicity;GO:2001234|negative regulation of apoptotic signaling pathway;GO:2001240|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0032809|neuronal cell body membrane;GO:0043005|neuron projection;GO:0048471|perinuclear region of cytoplasm;GO:0097447|dendritic tree;","GO:0004896|cytokine receptor activity;GO:0004930|G protein-coupled receptor activity;GO:0004950|chemokine receptor activity;GO:0016493|C-C chemokine receptor activity;GO:0016495|C-X3-C chemokine receptor activity;GO:0019957|C-C chemokine binding;GO:0019960|C-X3-C chemokine binding;GO:0031737|CX3C chemokine receptor binding;","K04192","CX3CR1; CX3C chemokine receptor 1"]
["ENSRNOG00000029756",98,8.136612731,0,0.032165219,252.9630751,7.982783,{"v":2.64492e-25,"d":"2.64E-25"},{"v":1.20284E-24,"d":"1.20E-24"},"up","yes","P2ry13","protein_coding","chr2:143470425-143473434:-","gi|50811827|ref|NP_001002853.1|",1775,0,"P2Y purinoceptor 13 [Rattus norvegicus]","gi|672042351|ref|XM_008760991.1|",2556,0,"PREDICTED: Rattus norvegicus purinergic receptor P2Y, G-protein coupled, 13 (P2ry13), transcript variant X1, mRNA","Q6GUG4",688,0,"P2Y purinoceptor 13",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0007194|negative regulation of adenylate cyclase activity;GO:0035589|G protein-coupled purinergic nucleotide receptor signaling pathway;GO:0071407|cellular response to organic cyclic compound;","GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0045028|G protein-coupled purinergic nucleotide receptor activity;","K08388","P2RY13; P2Y purinoceptor 13"]
["ENSRNOG00000019140",433,35.95054401,250,16.08260955,2.235367582,1.160512086,{"v":3.79359e-25,"d":"3.79E-25"},{"v":1.71667e-24,"d":"1.72E-24"},"up","yes","Banp","protein_coding","chr19:50007881-50082738:+","gi|157822243|ref|NP_001099661.1|",2738,0,"protein BANP [Rattus norvegicus]","gi|672085189|ref|XM_006255751.2|",2324,0,"PREDICTED: Rattus norvegicus Btg3 associated nuclear protein (Banp), transcript variant X1, mRNA","Q8VBU8",1052,0,"Protein BANP",".",".",".",".","pfam10523","BEN","BEN domain. The BEN domain is found in diverse animal proteins such as BANP/SMAR1, NAC1 and the Drosophila mod(mdg4) isoform C, in the chordopoxvirus virosomal protein E5R and in several proteins of polydnaviruses. Computational analysis suggests that the BEN domain mediates protein-DNA and protein-protein interactions during chromatin organisation and transcription.","GO:0034504|protein localization to nucleus;GO:0042177|negative regulation of protein catabolic process;GO:0045893|positive regulation of transcription, DNA-templated;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0016604|nuclear body;","GO:0002039|p53 binding;GO:0003677|DNA binding;GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000012208",134,11.12557251,26,1.672591393,6.651697813,2.733722628,{"v":4.84948e-25,"d":"4.85E-25"},{"v":2.18984E-24,"d":"2.19E-24"},"up","yes","Itgb7","protein_coding","chr7:133347960-133364876:-","gi|274320328|ref|NP_037303.1|",3772,0,"integrin beta-7 precursor [Rattus norvegicus]","gi|672059839|ref|XM_006242383.2|",2695,0,"PREDICTED: Rattus norvegicus integrin, beta 7 (Itgb7), transcript variant X1, mRNA","P26011",1361,0,"Integrin beta-7",".",".",".",".","pfam00362","Integrin_beta","Integrin, beta chain. Integrins have been found in animals and their homologues have also been found in cyanobacteria, probably due to horizontal gene transfer. The sequences repeats have been trimmed due to an overlap with EGF.","GO:0003366|cell-matrix adhesion involved in ameboidal cell migration;GO:0007160|cell-matrix adhesion;GO:0007229|integrin-mediated signaling pathway;GO:0016477|cell migration;GO:0033627|cell adhesion mediated by integrin;GO:0034113|heterotypic cell-cell adhesion;GO:0034446|substrate adhesion-dependent cell spreading;GO:0043113|receptor clustering;GO:0050900|leukocyte migration;GO:0050901|leukocyte tethering or rolling;GO:0072678|T cell migration;","GO:0005925|focal adhesion;GO:0008305|integrin complex;GO:0009986|cell surface;GO:0034669|integrin alpha4-beta7 complex;GO:0043235|receptor complex;","GO:0005178|integrin binding;GO:0038023|signaling receptor activity;GO:0050839|cell adhesion molecule binding;","K06590","ITGB7; integrin beta 7"]
["ENSRNOG00000013564",236,19.59429188,92,5.918400313,3.310741222,1.727154249,{"v":5.86393e-25,"d":"5.86E-25"},{"v":2.63675E-24,"d":"2.64E-24"},"up","yes","Dok3","protein_coding","chr17:9109597-9115188:+","gi|157823803|ref|NP_001100806.1|",1790,0,"docking protein 3 [Rattus norvegicus]","gi|74217653|dbj|AK156060.1|",1457,0,"Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830006H02 product:Adaptor protein (Inhibitory adapter molecule DOK3) homolog [Mus musculus], full insert sequence","B2RYG7",694,0,"Docking protein 3",".",".",".",".","pfam02174","IRS","PTB domain (IRS-1 type).","GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007265|Ras protein signal transduction;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;",".","K24036","DOK3; docking protein 3"]
["ENSRNOG00000059406",462,38.35831716,277,17.81953138,2.152599659,1.106080032,{"v":7.38768e-25,"d":"7.39E-25"},{"v":3.31027e-24,"d":"3.31E-24"},"up","yes","Ier5","protein_coding","chr13:67270135-67272227:-","gi|60551405|gb|AAH91181.1|",313,{"v":2e-31,"d":"2.00E-31"},"Ier5 protein [Rattus norvegicus]","gi|60551404|gb|BC091181.1|",1368,0,"Rattus norvegicus immediate early response 5, mRNA (cDNA clone IMAGE:7326120), complete cds","O89113",122,{"v":8e-30,"d":"8.00E-30"},"Immediate early response gene 5 protein",".",".",".",".","pfam05760","IER","Immediate early response protein (IER). This family consists of several eukaryotic immediate early response (IER) 2 and 5 proteins. The role of IER5 is unclear although it play an important role in mediating the cellular response to mitogenic signals. Again, little is known about the function of IER2 although it is thought to play a role in mediating the cellular responses to a variety of extracellular signals.","GO:0034605|cellular response to heat;GO:0042127|regulation of cell proliferation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:1900036|positive regulation of cellular response to heat;","GO:0000159|protein phosphatase type 2A complex;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;","GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000065590",120,9.963199263,19,1.222278326,8.15133432,3.027036238,{"v":7.51722e-25,"d":"7.52E-25"},{"v":3.36125e-24,"d":"3.36E-24"},"up","yes","Gpr65","protein_coding","chr6:117515648-117536512:+","gi|157822703|ref|NP_001100221.1|",1678,0,"psychosine receptor [Rattus norvegicus]","gi|672056501|ref|XM_008764761.1|",1584,0,"PREDICTED: Rattus norvegicus G-protein coupled receptor 65 (Gpr65), transcript variant X1, mRNA","Q61038",593,0,"Psychosine receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.",".",".",".",".","."]
["ENSRNOG00000064743",88,7.306346126,1,0.064330438,113.5752582,6.827504775,{"v":7.74119e-25,"d":"7.74E-25"},{"v":3.45898e-24,"d":"3.46E-24"},"up","yes","ENSRNOG00000064743","rRNA","chr3:2235683-2240483:+","gi|954470796|gb|KRZ01443.1|",894,{"v":4e-105,"d":"4.00E-105"},"hypothetical protein T11_16386 [Trichinella zimbabwensis]","gi|374429576|ref|NR_046246.1|",4681,0,"Rattus norvegicus 28S ribosomal RNA (Rn28s), ribosomal RNA","P47226",70.5,{"v":5e-11,"d":"5.00E-11"},"Testin",".",".",".",".","pfam15498","Dendrin","Nephrin and CD2AP-binding protein, Dendrin. Dendrin is a family of eukaryotic proteins found in the podocytes of the kidneys. Dendrin, originally identified in telencephalic dendrites, is a constituent of the slit diaphragm, SD, complex of podocytes, where it directly binds to nephrin and CD2AP. Kidney podocytes and their slit diaphragms (SDs) form the final barrier to urinary protein loss. SD proteins also participate in intracellular signalling pathways. Dendrin appears to prevent programmed cell death (apoptosis) through its binding to nephrin. The SD protein nephrin serves as a component of a signalling complex that directly links podocyte junctional integrity to actin cytoskeletal dynamics. Thus, dendrin is identified as an SD family with proapoptotic signalling properties that accumulates in the podocyte nucleus in response to glomerular injury.",".",".",".",".","."]
["ENSRNOG00000030212",145,12.03886578,33,2.12290446,5.670940922,2.503588127,{"v":1.2177E-24,"d":"1.22E-24"},{"v":5.41453e-24,"d":"5.41E-24"},"up","yes","Cerkl","protein_coding","chr3:64237522-64340675:-","gi|148695295|gb|EDL27242.1|",2372,0,"mCG20062, isoform CRA_b, partial [Mus musculus]","gi|672046046|ref|XR_086195.4|",1797,0,"PREDICTED: Rattus norvegicus ceramide kinase-like (Cerkl), transcript variant X2, misc_RNA","Q49MI3",769,0,"Ceramide kinase-like protein",".",".",".",".","pfam00781","DAGK_cat","Diacylglycerol kinase catalytic domain. Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologues. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.","GO:0008150|biological_process;GO:0016310|phosphorylation;GO:0030148|sphingolipid biosynthetic process;GO:0043066|negative regulation of apoptotic process;GO:0046834|lipid phosphorylation;","GO:0001750|photoreceptor outer segment;GO:0001917|photoreceptor inner segment;GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0048471|perinuclear region of cytoplasm;","GO:0003674|molecular_function;GO:0003951|NAD+ kinase activity;GO:0046625|sphingolipid binding;",".","."]
["ENSRNOG00000026644",411,34.12395748,234,15.05332254,2.26687214,1.18070302,{"v":1.41785e-24,"d":"1.42E-24"},{"v":6.28702e-24,"d":"6.29E-24"},"up","yes","Glipr1","protein_coding","chr7:47487345-47498429:-","gi|58865542|ref|NP_001011987.1|",1240,{"v":7e-169,"d":"7.00E-169"},"glioma pathogenesis-related protein 1 precursor [Rattus norvegicus]","gi|298881279|emb|FQ229810.1|",1036,0,"Rattus norvegicus TL0ADA46YJ18 mRNA sequence","Q9CWG1",377,{"v":5e-129,"d":"5.00E-129"},"Glioma pathogenesis-related protein 1","YJL079c",64.7,{"v":6E-11,"d":"6.00E-11"},"COG2340","pfam00188","CAP","Cysteine-rich secretory protein family. This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organisms, including prokaryotes and non-vertebrate eukaryotes, The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumor suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilisation. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The Ca++-chelating function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how helothermine from Heloderma horridum horridum blocks the Ca++ transporting ryanodine receptors.",".","GO:0005615|extracellular space;GO:0016021|integral component of membrane;",".","K24834","GLIPR1; glioma pathogenesis-related protein 1"]
["ENSRNOG00000003597",196,16.27322546,66,4.24580892,3.832773864,1.938388881,{"v":2.60706e-24,"d":"2.61E-24"},{"v":1.14569E-23,"d":"1.15E-23"},"up","yes","Tuba4a","protein_coding","chr9:76709614-76713918:-","gi|821032162|ref|XP_012355059.1|",2315,0,"PREDICTED: tubulin alpha-4A chain isoform X2 [Nomascus leucogenys]","gi|298905785|emb|FQ212913.1|",2021,0,"Rattus norvegicus TL0AAA50YL06 mRNA sequence","Q5XIF6",895,0,"Tubulin alpha-4A chain","SPBC800.05c",717,0,"COG5023","pfam03953","Tubulin_C","Tubulin C-terminal domain. This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).","GO:0000226|microtubule cytoskeleton organization;GO:0000278|mitotic cell cycle;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005874|microtubule;GO:0015630|microtubule cytoskeleton;","GO:0003674|molecular_function;GO:0003924|GTPase activity;GO:0005200|structural constituent of cytoskeleton;GO:0005525|GTP binding;GO:0019899|enzyme binding;GO:0019901|protein kinase binding;","K07374","TUBA; tubulin alpha"]
["ENSRNOG00000018163",88,7.306346126,5,0.321652191,22.71505164,4.50557668,{"v":3.14325e-24,"d":"3.14E-24"},{"v":1.37754e-23,"d":"1.38E-23"},"up","yes","Ipcef1","protein_coding","chr1:43269202-43427969:-","gi|282847440|ref|NP_001164270.1|",1878,0,"interactor protein for cytohesin exchange factors 1 [Rattus norvegicus]","gi|755532676|ref|XM_011243080.1|",2018,0,"PREDICTED: Mus musculus interaction protein for cytohesin exchange factors 1 (Ipcef1), transcript variant X1, mRNA","Q80VL0",728,0,"Interactor protein for cytohesin exchange factors 1",".",".",".",".","pfam00169","PH","PH domain. PH stands for pleckstrin homology.",".","GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0005515|protein binding;GO:0019904|protein domain specific binding;","K23795","IPCEF1; interactor protein for cytohesin exchange factors 1"]
["ENSRNOG00000012802",336,27.89695794,173,11.12916581,2.506653097,1.325762351,{"v":4.03857e-24,"d":"4.04E-24"},{"v":1.76026e-23,"d":"1.76E-23"},"up","yes","Tenm3","protein_coding","chr16:41252182-43978594:+","gi|281306744|ref|NP_001162604.1|",14151,0,"teneurin-3 [Rattus norvegicus]","gi|619328952|ref|NM_001169133.2|",10972,0,"Rattus norvegicus teneurin transmembrane protein 3 (Tenm3), mRNA","Q9WTS6",5420,0,"Teneurin-3",".",".",".",".","pfam06484","Ten_N","Teneurin Intracellular Region. This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).","GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007165|signal transduction;GO:0010976|positive regulation of neuron projection development;GO:0048593|camera-type eye morphogenesis;GO:0048666|neuron development;GO:1903385|regulation of homophilic cell adhesion;","GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0043005|neuron projection;","GO:0003824|catalytic activity;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0046982|protein heterodimerization activity;GO:0050839|cell adhesion molecule binding;","K24473","TENM, ODZ; teneurin"]
["ENSRNOG00000019737",453,37.61107722,274,17.62654006,2.13377538,1.093408313,{"v":5.52257e-24,"d":"5.52E-24"},{"v":2.39079e-23,"d":"2.39E-23"},"up","yes","Sema4a","protein_coding","chr2:173896439-173914442:-","gi|403224995|ref|NP_001012078.2|",3757,0,"semaphorin-4A precursor [Rattus norvegicus]","gi|403224994|ref|NM_001012078.2|",3147,0,"Rattus norvegicus semaphorin 4A (Sema4a), mRNA","Q62178",1378,0,"Semaphorin-4A",".",".",".",".","pfam01403","Sema","Sema domain. The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and human plexin A-3.","GO:0001755|neural crest cell migration;GO:0002292|T cell differentiation involved in immune response;GO:0007409|axonogenesis;GO:0007411|axon guidance;GO:0008360|regulation of cell shape;GO:0010594|regulation of endothelial cell migration;GO:0016525|negative regulation of angiogenesis;GO:0030335|positive regulation of cell migration;GO:0045063|T-helper 1 cell differentiation;GO:0048843|negative regulation of axon extension involved in axon guidance;GO:0050919|negative chemotaxis;GO:0071526|semaphorin-plexin signaling pathway;GO:1904891|positive regulation of excitatory synapse assembly;GO:1905704|positive regulation of inhibitory synapse assembly;","GO:0005615|extracellular space;GO:0005887|integral component of plasma membrane;","GO:0030215|semaphorin receptor binding;GO:0045499|chemorepellent activity;","K06521","SEMA4, CD100; semaphorin 4"]
["ENSRNOG00000071032",98,8.136612731,10,0.643304382,12.64815375,3.660854905,{"v":6.77025e-24,"d":"6.77E-24"},{"v":2.91709e-23,"d":"2.92E-23"},"up","yes","Mmp25","protein_coding","chr10:12661208-12675871:-","gi|293339906|ref|XP_001055465.2|",2777,0,"PREDICTED: matrix metalloproteinase-25 isoform X1 [Rattus norvegicus]","gi|672024565|ref|XM_001055465.4|",3146,0,"PREDICTED: Rattus norvegicus matrix metallopeptidase 25 (Mmp25), transcript variant X1, mRNA","Q3U435",918,0,"Matrix metalloproteinase-25",".",".",".",".","pfam00413","Peptidase_M10","Matrixin. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.",".",".",".",".","."]
["ENSRNOG00000048914",226,18.76402528,89,5.725408998,3.277324866,1.712518688,{"v":1.05287e-23,"d":"1.05E-23"},{"v":4.51219e-23,"d":"4.51E-23"},"up","yes","Traf1","protein_coding","chr3:18222054-18241807:-","gi|403420632|ref|NP_001258169.1|",1919,0,"TNF receptor-associated factor 1 [Rattus norvegicus]","gi|672045342|ref|XM_006233999.2|",1979,0,"PREDICTED: Rattus norvegicus TNF receptor-associated factor 1 (Traf1), transcript variant X1, mRNA","P39428",711,0,"TNF receptor-associated factor 1",".",".",".",".","pfam00917","MATH","MATH domain. This motif has been called the Meprin And TRAF-Homology (MATH) domain. This domain is hugely expanded in the nematode C. elegans.","GO:0033209|tumor necrosis factor-mediated signaling pathway;GO:0043122|regulation of I-kappaB kinase/NF-kappaB signaling;GO:0046330|positive regulation of JNK cascade;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0070534|protein K63-linked ubiquitination;GO:2001236|regulation of extrinsic apoptotic signaling pathway;","GO:0005737|cytoplasm;GO:0009898|cytoplasmic side of plasma membrane;GO:0098802|plasma membrane receptor complex;","GO:0005164|tumor necrosis factor receptor binding;GO:0008270|zinc ion binding;GO:0031625|ubiquitin protein ligase binding;GO:0031996|thioesterase binding;GO:0042802|identical protein binding;","K03172","TRAF1; TNF receptor-associated factor 1"]
["ENSRNOG00000016456",209,17.35257205,77,4.95344374,3.503132964,1.808645748,{"v":1.1828E-23,"d":"1.18E-23"},{"v":5.06561e-23,"d":"5.07E-23"},"up","yes","Il33","protein_coding","chr1:227721435-227736373:+","gi|62079057|ref|NP_001014188.1|",808,{"v":9e-96,"d":"9.00E-96"},"interleukin-33 [Rattus norvegicus]","gi|62079056|ref|NM_001014166.1|",2051,0,"Rattus norvegicus interleukin 33 (Il33), mRNA","Q66H70",315,{"v":3e-97,"d":"3.00E-97"},"Interleukin-33",".",".",".",".","pfam15095","IL33","Interleukin 33.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001819|positive regulation of cytokine production;GO:0002281|macrophage activation involved in immune response;GO:0002282|microglial cell activation involved in immune response;GO:0002638|negative regulation of immunoglobulin production;GO:0002639|positive regulation of immunoglobulin production;GO:0002686|negative regulation of leukocyte migration;GO:0002826|negative regulation of T-helper 1 type immune response;GO:0002830|positive regulation of type 2 immune response;GO:0010186|positive regulation of cellular defense response;GO:0010628|positive regulation of gene expression;GO:0032436|positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032689|negative regulation of interferon-gamma production;GO:0032722|positive regulation of chemokine production;GO:0032736|positive regulation of interleukin-13 production;GO:0032753|positive regulation of interleukin-4 production;GO:0032754|positive regulation of interleukin-5 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0038172|interleukin-33-mediated signaling pathway;GO:0042060|wound healing;GO:0043032|positive regulation of macrophage activation;GO:0045345|positive regulation of MHC class I biosynthetic process;GO:0045348|positive regulation of MHC class II biosynthetic process;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048714|positive regulation of oligodendrocyte differentiation;GO:0050729|positive regulation of inflammatory response;GO:0051607|defense response to virus;GO:0051770|positive regulation of nitric-oxide synthase biosynthetic process;GO:0051930|regulation of sensory perception of pain;GO:0061518|microglial cell proliferation;GO:0071260|cellular response to mechanical stimulus;GO:0097191|extrinsic apoptotic signaling pathway;GO:0120042|negative regulation of macrophage proliferation;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005694|chromosome;GO:0005737|cytoplasm;GO:0030133|transport vesicle;GO:0043231|intracellular membrane-bounded organelle;","GO:0002112|interleukin-33 receptor binding;GO:0005125|cytokine activity;GO:0005515|protein binding;","K12967","IL33; interleukin 33"]
["ENSRNOG00000051986",166,13.78242565,49,3.152191471,4.372331368,2.128402743,{"v":2.59205e-23,"d":"2.59E-23"},{"v":1.0911e-22,"d":"1.09E-22"},"up","yes","Plcg2","protein_coding","chr19:45547416-45683930:+","gi|148679636|gb|EDL11583.1|",6979,0,"phospholipase C, gamma 2 [Mus musculus]","gi|8393983|ref|NM_017168.1|",4282,0,"Rattus norvegicus phospholipase C, gamma 2 (Plcg2), mRNA","P24135",2620,0,"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2",".",".",".",".","pfam00388","PI-PLC-X","Phosphatidylinositol-specific phospholipase C, X domain. This associates with pfam00387 to form a single structural unit.","GO:0001775|cell activation;GO:0001878|response to yeast;GO:0002092|positive regulation of receptor internalization;GO:0002223|stimulatory C-type lectin receptor signaling pathway;GO:0002224|toll-like receptor signaling pathway;GO:0002281|macrophage activation involved in immune response;GO:0002316|follicular B cell differentiation;GO:0002732|positive regulation of dendritic cell cytokine production;GO:0006661|phosphatidylinositol biosynthetic process;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0009395|phospholipid catabolic process;GO:0010468|regulation of gene expression;GO:0010628|positive regulation of gene expression;GO:0010634|positive regulation of epithelial cell migration;GO:0019216|regulation of lipid metabolic process;GO:0019722|calcium-mediated signaling;GO:0030183|B cell differentiation;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0032026|response to magnesium ion;GO:0032237|activation of store-operated calcium channel activity;GO:0032481|positive regulation of type I interferon production;GO:0032496|response to lipopolysaccharide;GO:0032733|positive regulation of interleukin-10 production;GO:0032735|positive regulation of interleukin-12 production;GO:0032743|positive regulation of interleukin-2 production;GO:0032747|positive regulation of interleukin-23 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032959|inositol trisphosphate biosynthetic process;GO:0033198|response to ATP;GO:0035556|intracellular signal transduction;GO:0043069|negative regulation of programmed cell death;GO:0043122|regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043410|positive regulation of MAPK cascade;GO:0048678|response to axon injury;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050850|positive regulation of calcium-mediated signaling;GO:0050852|T cell receptor signaling pathway;GO:0050853|B cell receptor signaling pathway;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051209|release of sequestered calcium ion into cytosol;GO:0060100|positive regulation of phagocytosis, engulfment;GO:0060907|positive regulation of macrophage cytokine production;GO:0061760|antifungal innate immune response;GO:0070884|regulation of calcineurin-NFAT signaling cascade;GO:0071277|cellular response to calcium ion;GO:0071396|cellular response to lipid;GO:0150078|positive regulation of neuroinflammatory response;GO:1900227|positive regulation of NLRP3 inflammasome complex assembly;GO:1902808|positive regulation of cell cycle G1/S phase transition;GO:1903428|positive regulation of reactive oxygen species biosynthetic process;GO:1903721|positive regulation of I-kappaB phosphorylation;GO:1990858|cellular response to lectin;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0032587|ruffle membrane;GO:0048471|perinuclear region of cytoplasm;GO:0097708|intracellular vesicle;","GO:0001784|phosphotyrosine residue binding;GO:0004435|phosphatidylinositol phospholipase C activity;GO:0005515|protein binding;GO:0019901|protein kinase binding;GO:0097110|scaffold protein binding;GO:0140031|phosphorylation-dependent protein binding;GO:1990782|protein tyrosine kinase binding;","K05859","PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]"]
["ENSRNOG00000019445",89,7.389372787,7,0.450313067,16.4094123,4.036451665,{"v":3.26777e-23,"d":"3.27E-23"},{"v":1.36923E-22,"d":"1.37E-22"},"up","yes","Msln","protein_coding","chr10:14771961-14777643:-","gi|564371087|ref|XP_006246083.1|",3003,0,"PREDICTED: mesothelin isoform X1 [Rattus norvegicus]","gi|14389304|ref|NM_031658.1|",2063,0,"Rattus norvegicus mesothelin (Msln), mRNA","Q9ERA7",1163,0,"Mesothelin",".",".",".",".","pfam06060","Mesothelin","Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin). This family consists of several mammalian pre-pro-megakaryocyte potentiating factor precursor (MPF) or mesothelin proteins. Mesothelin is a glycosylphosphatidylinositol-linked glycoprotein highly expressed in mesothelial cells, mesotheliomas, and ovarian cancer, but the biological function of the protein is not known.","GO:0007160|cell-matrix adhesion;GO:0031016|pancreas development;","GO:0005615|extracellular space;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0031225|anchored component of membrane;","GO:0003674|molecular_function;","K20733","MSLN; mesothelin"]
["ENSRNOG00000000855",132,10.95951919,29,1.865582707,5.87458232,2.55448628,{"v":4.68078e-23,"d":"4.68E-23"},{"v":1.95107e-22,"d":"1.95E-22"},"up","yes","Lst1","protein_coding","chr20:3634749-3637997:+","gi|260166685|ref|NP_072156.2|",520,{"v":4e-65,"d":"4.00E-65"},"leukocyte-specific transcript 1 protein [Rattus norvegicus]","gi|260166684|ref|NM_022634.2|",438,0,"Rattus norvegicus leukocyte specific transcript 1 (Lst1), mRNA","O08843",79.7,{"v":3e-18,"d":"3.00E-18"},"Leukocyte-specific transcript 1 protein",".",".",".",".","pfam05083","LST1","LST-1 protein. B144/LST1 is a gene encoded in the human major histocompatibility complex that produces multiple forms of alternatively spliced mRNA and encodes peptides fewer than 100 amino acids in length. B144/LST1 is strongly expressed in dendritic cells. Transfection of B144/LST1 into a variety of cells induces morphologic changes including the production of long, thin filopodia.","GO:0000902|cell morphogenesis;GO:0006955|immune response;GO:0008150|biological_process;GO:0016358|dendrite development;GO:0050672|negative regulation of lymphocyte proliferation;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;",".","."]
["ENSRNOG00000005903",186,15.44295886,63,4.052817606,3.810425329,1.929952044,{"v":4.99503e-23,"d":"5.00E-23"},{"v":2.07934e-22,"d":"2.08E-22"},"up","yes","St14","protein_coding","chr8:29540811-29581517:-","gi|16758444|ref|NP_446087.1|",4509,0,"suppressor of tumorigenicity 14 protein [Rattus norvegicus]","gi|31377480|ref|NM_053635.2|",3150,0,"Rattus norvegicus suppression of tumorigenicity 14 (St14), mRNA","P56677",1661,0,"Suppressor of tumorigenicity 14 protein homolog","VC1200",112,{"v":3e-25,"d":"3.00E-25"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0001843|neural tube closure;GO:0006508|proteolysis;GO:0030216|keratinocyte differentiation;GO:0060672|epithelial cell morphogenesis involved in placental branching;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0019897|extrinsic component of plasma membrane;","GO:0004252|serine-type endopeptidase activity;GO:0008236|serine-type peptidase activity;","K08670","ST14, PRSS14; suppressor of tumorigenicity protein 14 [EC:3.4.21.109]"]
["ENSRNOG00000012622",293,24.32681153,143,9.19925266,2.644433459,1.402958674,{"v":5.18282e-23,"d":"5.18E-23"},{"v":2.15611E-22,"d":"2.16E-22"},"up","yes","Mmp15","protein_coding","chr19:9663449-9684943:-","gi|157818219|ref|NP_001099638.1|",2797,0,"matrix metalloproteinase-15 precursor [Rattus norvegicus]","gi|158261997|ref|NM_001106168.2|",3818,0,"Rattus norvegicus matrix metallopeptidase 15 (Mmp15), mRNA","O54732",1064,0,"Matrix metalloproteinase-15",".",".",".",".","pfam00413","Peptidase_M10","Matrixin. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.","GO:0006508|proteolysis;GO:0030198|extracellular matrix organization;GO:0030574|collagen catabolic process;GO:0032355|response to estradiol;GO:0035987|endodermal cell differentiation;","GO:0005887|integral component of plasma membrane;GO:0031012|extracellular matrix;","GO:0004222|metalloendopeptidase activity;GO:0008270|zinc ion binding;","K07995","MMP15; matrix metalloproteinase-15 (membrane-inserted) [EC:3.4.24.-]"]
["ENSRNOG00000007319",153,12.70307906,42,2.701878404,4.701573188,2.233143576,{"v":7.60444e-23,"d":"7.60E-23"},{"v":3.14309E-22,"d":"3.14E-22"},"up","yes","Trib3","protein_coding","chr3:140809043-140814497:-","gi|21426781|ref|NP_653356.1|",1699,0,"tribbles homolog 3 [Rattus norvegicus]","gi|4827158|dbj|AB020967.1|",1844,0,"Rattus sp. mRNA for kinase, complete cds","Q9WTQ6",659,0,"Tribbles homolog 3",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006468|protein phosphorylation;GO:0006469|negative regulation of protein kinase activity;GO:0010506|regulation of autophagy;GO:0010827|regulation of glucose transmembrane transport;GO:0012501|programmed cell death;GO:0032092|positive regulation of protein binding;GO:0032436|positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032869|cellular response to insulin stimulus;GO:0034976|response to endoplasmic reticulum stress;GO:0043405|regulation of MAP kinase activity;GO:0045599|negative regulation of fat cell differentiation;GO:0045717|negative regulation of fatty acid biosynthetic process;GO:0045892|negative regulation of transcription, DNA-templated;GO:0051443|positive regulation of ubiquitin-protein transferase activity;GO:0070059|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;","GO:0005634|nucleus;GO:0005654|nucleoplasm;","GO:0003714|transcription corepressor activity;GO:0004860|protein kinase inhibitor activity;GO:0005524|ATP binding;GO:0019899|enzyme binding;GO:0019901|protein kinase binding;GO:0031434|mitogen-activated protein kinase kinase binding;GO:0031625|ubiquitin protein ligase binding;GO:0055106|ubiquitin-protein transferase regulator activity;","K19518","TRIB3; tribbles homolog 3"]
["ENSRNOG00000066264",208,17.26954539,79,5.082104617,3.398108991,1.764732126,{"v":8.13493e-23,"d":"8.13E-23"},{"v":3.35801e-22,"d":"3.36E-22"},"up","yes","RGD1563400","protein_coding","chr12:18566837-18582202:-","gi|564323654|ref|XP_006227213.1|",1042,{"v":8e-130,"d":"8.00E-130"},"PREDICTED: paired immunoglobulin-like type 2 receptor beta-2 isoform X1 [Rattus norvegicus]","gi|672072478|ref|XM_008769083.1|",1467,0,"PREDICTED: Rattus norvegicus similar to paired immunoglobin-like type 2 receptor beta (RGD1563400), transcript variant X7, mRNA","Q2YFS2",289,{"v":4e-88,"d":"4.00E-88"},"Paired immunoglobulin-like type 2 receptor beta",".",".",".",".","pfam13871","Helicase_C_4","Helicase_C-like. Strawberry notch proteins carry DExD/H-box groups and Helicase_C domains. These proteins promote the expression of diverse targets, potentially through interactions with transcriptional activator or repressor complexes.",".",".",".",".","."]
["ENSRNOG00000039754",278,23.08141163,133,8.555948279,2.697703501,1.431731793,{"v":1.5089e-22,"d":"1.51E-22"},{"v":6.16884e-22,"d":"6.17E-22"},"up","yes","Rab7b","protein_coding","chr13:43121226-43147581:+","gi|149058661|gb|EDM09818.1|",1080,{"v":1e-138,"d":"1.00E-138"},"similar to RAB7-like protein (predicted), isoform CRA_a [Rattus norvegicus]","gi|404247438|ref|NM_001109328.2|",2500,0,"Rattus norvegicus Rab7b, member RAS oncogene family (Rab7b), mRNA","Q8VEA8",401,{"v":5e-133,"d":"5.00E-133"},"Ras-related protein Rab-7b",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0008333|endosome to lysosome transport;GO:0032755|positive regulation of interleukin-6 production;GO:0034144|negative regulation of toll-like receptor 4 signaling pathway;GO:0034164|negative regulation of toll-like receptor 9 signaling pathway;GO:0034499|late endosome to Golgi transport;GO:0045654|positive regulation of megakaryocyte differentiation;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0071346|cellular response to interferon-gamma;GO:0090385|phagosome-lysosome fusion;","GO:0005764|lysosome;GO:0005770|late endosome;GO:0005794|Golgi apparatus;GO:0005802|trans-Golgi network;GO:0045335|phagocytic vesicle;","GO:0003924|GTPase activity;GO:0005525|GTP binding;","K07898","RAB7B; Ras-related protein Rab-7B"]
["ENSRNOG00000012779",185,15.3599322,64,4.117148044,3.730721372,1.899454617,{"v":1.82988E-22,"d":"1.83E-22"},{"v":7.46201e-22,"d":"7.46E-22"},"up","yes","Msr1","protein_coding","chr16:52717732-52799676:+","gi|564389351|ref|XP_006253268.1|",2291,0,"PREDICTED: macrophage scavenger receptor types I and II isoform X1 [Rattus norvegicus]","gi|672080329|ref|XM_006253206.2|",1925,0,"PREDICTED: Rattus norvegicus macrophage scavenger receptor 1 (Msr1), transcript variant X1, mRNA","P30204",656,0,"Macrophage scavenger receptor types I and II",".",".",".",".","pfam00530","SRCR","Scavenger receptor cysteine-rich domain. These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.","GO:0006898|receptor-mediated endocytosis;GO:0006911|phagocytosis, engulfment;GO:0010629|negative regulation of gene expression;GO:0010744|positive regulation of macrophage derived foam cell differentiation;GO:0010886|positive regulation of cholesterol storage;GO:0030301|cholesterol transport;GO:0034381|plasma lipoprotein particle clearance;GO:0042953|lipoprotein transport;GO:0071407|cellular response to organic cyclic compound;GO:0097242|amyloid-beta clearance;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0031410|cytoplasmic vesicle;","GO:0001540|amyloid-beta binding;GO:0003674|molecular_function;GO:0005044|scavenger receptor activity;GO:0030169|low-density lipoprotein particle binding;GO:0038024|cargo receptor activity;","K06558","MSR1, CD204; macrophage scavenger receptor 1"]
["ENSRNOG00000018659",324,26.90063801,171,11.00050493,2.445400296,1.290070644,{"v":2.02836e-22,"d":"2.03E-22"},{"v":8.2661e-22,"d":"8.27E-22"},"up","yes","Csf1","protein_coding","chr2:195377215-195411704:-","gi|28201782|sp|Q8JZQ0.1|CSF1_RAT",2679,0,"RecName: Full=Macrophage colony-stimulating factor 1; Short=CSF-1; Short=MCSF; Contains: RecName: Full=Processed macrophage colony-stimulating factor 1; Flags: Precursor","gi|22255877|gb|AF515736.1|",2103,0,"Rattus norvegicus colony stimulating factor-1 (Csf1) mRNA, complete cds","Q8JZQ0",1037,0,"Macrophage colony-stimulating factor 1",".",".",".",".","pfam05337","CSF-1","Macrophage colony stimulating factor-1 (CSF-1). Colony stimulating factor 1 (CSF-1) is a homodimeric polypeptide growth factor whose primary function is to regulate the survival, proliferation, differentiation, and function of cells of the mononuclear phagocytic lineage. This lineage includes mononuclear phagocytic precursors, blood monocytes, tissue macrophages, osteoclasts, and microglia of the brain, all of which possess cell surface receptors for CSF-1. The protein has also been linked with male fertility and mutations in the Csf-1 gene have been found to cause osteopetrosis and failure of tooth eruption.","GO:0001503|ossification;GO:0001954|positive regulation of cell-matrix adhesion;GO:0002158|osteoclast proliferation;GO:0002931|response to ischemia;GO:0003006|developmental process involved in reproduction;GO:0006954|inflammatory response;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0008283|cell proliferation;GO:0008284|positive regulation of cell proliferation;GO:0010628|positive regulation of gene expression;GO:0010744|positive regulation of macrophage derived foam cell differentiation;GO:0010759|positive regulation of macrophage chemotaxis;GO:0030225|macrophage differentiation;GO:0030278|regulation of ossification;GO:0030316|osteoclast differentiation;GO:0030335|positive regulation of cell migration;GO:0032270|positive regulation of cellular protein metabolic process;GO:0032946|positive regulation of mononuclear cell proliferation;GO:0038145|macrophage colony-stimulating factor signaling pathway;GO:0040018|positive regulation of multicellular organism growth;GO:0042476|odontogenesis;GO:0042488|positive regulation of odontogenesis of dentin-containing tooth;GO:0045087|innate immune response;GO:0045651|positive regulation of macrophage differentiation;GO:0045657|positive regulation of monocyte differentiation;GO:0045672|positive regulation of osteoclast differentiation;GO:0045860|positive regulation of protein kinase activity;GO:0046579|positive regulation of Ras protein signal transduction;GO:0048873|homeostasis of number of cells within a tissue;GO:0060444|branching involved in mammary gland duct morphogenesis;GO:0060611|mammary gland fat development;GO:0060763|mammary duct terminal end bud growth;GO:0061518|microglial cell proliferation;GO:1901215|negative regulation of neuron death;GO:1902228|positive regulation of macrophage colony-stimulating factor signaling pathway;GO:1904141|positive regulation of microglial cell migration;GO:1905523|positive regulation of macrophage migration;","GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0016604|nuclear body;GO:0048471|perinuclear region of cytoplasm;GO:1990682|CSF1-CSF1R complex;","GO:0005125|cytokine activity;GO:0005157|macrophage colony-stimulating factor receptor binding;GO:0008083|growth factor activity;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;","K05453","CSF1, MCSF; macrophage colony-stimulating factor 1"]
["ENSRNOG00000014837",159,13.20123902,47,3.023530595,4.36616684,2.12636726,{"v":2.25931e-22,"d":"2.26E-22"},{"v":9.19558e-22,"d":"9.20E-22"},"up","yes","Emilin2","protein_coding","chr9:111160712-111220352:-","gi|672066409|ref|XP_008765663.1|",5182,0,"PREDICTED: EMILIN-2 isoform X2 [Rattus norvegicus]","gi|672024432|ref|XM_006226977.2|",3079,0,"PREDICTED: Rattus norvegicus elastin microfibril interfacer 2 (Emilin2), transcript variant X1, mRNA","Q8K482",1878,0,"EMILIN-2",".",".",".",".","pfam07546","EMI","EMI domain. The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.",".","GO:0005576|extracellular region;",".","K24246","EMILIN; emilin"]
["ENSRNOG00000054561",186,15.44295886,65,4.181478482,3.693181473,1.884864154,{"v":2.32236e-22,"d":"2.32E-22"},{"v":9.44618e-22,"d":"9.45E-22"},"up","yes","Isg20","protein_coding","chr1:132815123-132837027:+","gi|157817035|ref|NP_001101957.1|",1202,{"v":6E-158,"d":"6.00E-158"},"apoptosis-enhancing nuclease [Rattus norvegicus]","gi|186910199|ref|NM_001108487.2|",1068,0,"Rattus norvegicus apoptosis enhancing nuclease (Aen), mRNA","B2GUW6",467,{"v":2E-159,"d":"2.00E-159"},"Apoptosis-enhancing nuclease","YOL080c",123,{"v":2e-30,"d":"2.00E-30"},"COG0847","pfam00929","RNase_T","Exonuclease. This family includes a variety of exonuclease proteins, such as ribonuclease T and the epsilon subunit of DNA polymerase III.;","GO:0000738|DNA catabolic process, exonucleolytic;GO:0006401|RNA catabolic process;GO:0009615|response to virus;GO:0045071|negative regulation of viral genome replication;GO:0051607|defense response to virus;GO:0090503|RNA phosphodiester bond hydrolysis, exonucleolytic;","GO:0005634|nucleus;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0015030|Cajal body;GO:0016605|PML body;","GO:0000175|3'-5'-exoribonuclease activity;GO:0004527|exonuclease activity;GO:0008310|single-stranded DNA 3'-5' exodeoxyribonuclease activity;GO:0030619|U1 snRNA binding;GO:0030620|U2 snRNA binding;GO:0034511|U3 snoRNA binding;","K12579","ISG20; interferon-stimulated gene 20 kDa protein [EC:3.1.13.1]"]
["ENSRNOG00000070011",165,13.69939899,51,3.280852347,4.175560963,2.061970028,{"v":2.50324e-22,"d":"2.50E-22"},{"v":1.0169E-21,"d":"1.02E-21"},"up","yes","ENSRNOG00000070011","lncRNA","chr18:55095230-55118825:-","gi|149064411|gb|EDM14614.1|",541,{"v":1E-58,"d":"1.00E-58"},"rCG46786 [Rattus norvegicus]","gi|56044724|gb|AC115691.8|",1730,0,"Mus musculus chromosome 18, clone RP24-286B14, complete sequence",".",".",".",".",".",".",".",".","pfam12234","Rav1p_C","RAVE protein 1 C terminal. This domain family is found in eukaryotes, and is typically between 621 and 644 amino acids in length. This family is the C terminal region of the protein RAVE (regulator of the ATPase of vacuolar and endosomal membranes). Rav1p is involved in regulating the glucose dependent assembly and disassembly of vacuolar ATPase V1 and V0 subunits.",".",".",".",".","."]
["ENSRNOG00000037814",122,10.12925258,25,1.608260955,6.298264318,2.654954304,{"v":2.7417e-22,"d":"2.74E-22"},{"v":1.11094E-21,"d":"1.11E-21"},"up","yes","Cxcl17","protein_coding","chr1:80984964-80996726:-","gi|157819233|ref|NP_001100961.1|",626,{"v":3E-79,"d":"3.00E-79"},"VEGF coregulated chemokine 1 precursor [Rattus norvegicus]","gi|157819232|ref|NM_001107491.1|",795,0,"Rattus norvegicus chemokine (C-X-C motif) ligand 17 (Cxcl17), mRNA","Q5UW37",171,{"v":7e-52,"d":"7.00E-52"},"C-X-C motif chemokine 17",".",".",".",".","pfam15211","CXCL17","VEGF co-regulated chemokine 1.","GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0010759|positive regulation of macrophage chemotaxis;GO:0048246|macrophage chemotaxis;GO:0050728|negative regulation of inflammatory response;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0090026|positive regulation of monocyte chemotaxis;","GO:0005615|extracellular space;",".","K22627","CXCL17; C-X-C motif chemokine 17"]
["ENSRNOG00000030210",149,12.37097242,41,2.637547966,4.690330784,2.229689672,{"v":2.9894E-22,"d":"2.99E-22"},{"v":1.20901e-21,"d":"1.21E-21"},"up","yes","Fndc1","protein_coding","chr1:47281844-47364259:+","gi|564325199|ref|XP_006227933.1|",5986,0,"PREDICTED: fibronectin type III domain-containing protein 1 isoform X1 [Rattus norvegicus]","gi|672034288|ref|XM_006227871.2|",6335,0,"PREDICTED: Rattus norvegicus fibronectin type III domain containing 1 (Fndc1), transcript variant X1, mRNA","Q2Q0I9",2176,0,"Fibronectin type III domain-containing protein 1",".",".",".",".","pfam00041","fn3","Fibronectin type III domain.","GO:0001934|positive regulation of protein phosphorylation;GO:0010666|positive regulation of cardiac muscle cell apoptotic process;GO:0051223|regulation of protein transport;GO:0071456|cellular response to hypoxia;","GO:0005576|extracellular region;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0016607|nuclear speck;GO:0031966|mitochondrial membrane;",".","K24484","FNDC1; fibronectin type III domain-containing protein 1"]
["ENSRNOG00000007918",166,13.78242565,53,3.409513224,4.042344095,2.015192133,{"v":7.63373e-22,"d":"7.63E-22"},{"v":3.05259e-21,"d":"3.05E-21"},"up","yes","Tbxas1","protein_coding","chr4:67665007-67837096:+","gi|6981634|ref|NP_036819.1|",2590,0,"thromboxane-A synthase [Rattus norvegicus]","gi|6981633|ref|NM_012687.1|",1813,0,"Rattus norvegicus thromboxane A synthase 1 (Tbxas1), mRNA","P49430",998,0,"Thromboxane-A synthase","VNG0422G",126,{"v":1e-30,"d":"1.00E-30"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0001516|prostaglandin biosynthetic process;GO:0006690|icosanoid metabolic process;GO:0030644|cellular chloride ion homeostasis;GO:0045471|response to ethanol;GO:0045907|positive regulation of vasoconstriction;GO:0070542|response to fatty acid;","GO:0005575|cellular_component;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0004497|monooxygenase activity;GO:0004796|thromboxane-A synthase activity;GO:0005506|iron ion binding;GO:0016705|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0020037|heme binding;GO:0036134|12-hydroxyheptadecatrienoic acid synthase activity;","K01832","TBXAS1, CYP5A; thromboxane-A synthase [EC:5.3.99.5]"]
["ENSRNOG00000053337",82,6.808186163,6,0.385982629,17.63858176,4.14066266,{"v":8.23323e-22,"d":"8.23E-22"},{"v":3.28615e-21,"d":"3.29E-21"},"up","yes","Ly49s6","protein_coding","chr4:163884837-164104899:-","gi|56789198|gb|AAH88257.1|",745,{"v":7e-93,"d":"7.00E-93"},"Ly49s6 protein [Rattus norvegicus]","gi|56789197|gb|BC088257.1|",1702,0,"Rattus norvegicus Ly49 stimulatory receptor 6, mRNA (cDNA clone MGC:109079 IMAGE:7375677), complete cds","Q60682",139,{"v":5E-36,"d":"5.00E-36"},"Killer cell lectin-like receptor 8",".",".",".",".","pfam08391","Ly49","Ly49-like protein, N-terminal region. The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000030012",105,8.717799355,17,1.093617449,7.971525474,2.994855833,{"v":9.71878e-22,"d":"9.72E-22"},{"v":3.86942e-21,"d":"3.87E-21"},"up","yes","Clec4a2","protein_coding","chr4:156262692-156321392:+","gi|45758796|gb|AAS76657.1|",1177,{"v":4e-161,"d":"4.00E-161"},"dendritic cell inhibitory receptor 2 [Rattus norvegicus]","gi|45758795|gb|AY494061.1|",790,0,"Rattus norvegicus strain DA dendritic cell inhibitory receptor 2 (Dcir2) mRNA, complete cds","Q67EQ0",293,{"v":6E-98,"d":"6.00E-98"},"C-type lectin domain family 4 member A",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type",".",".","GO:0030246|carbohydrate binding;","K10057","CLEC4A, CD367; C-type lectin domain family 4 member A"]
["ENSRNOG00000000441",204,16.93743875,80,5.146435055,3.291101232,1.718570403,{"v":1.18662e-21,"d":"1.19E-21"},{"v":4.71559e-21,"d":"4.72E-21"},"up","yes","Gpsm3","protein_coding","chr20:4157123-4159035:-","gi|51571901|ref|NP_001003974.1|",339,{"v":3E-34,"d":"3.00E-34"},"G-protein-signaling modulator 3 [Rattus norvegicus]","gi|56961638|ref|NM_001003974.2|",781,0,"Rattus norvegicus G-protein signaling modulator 3 (Gpsm3), mRNA","Q6MG88",135,{"v":9e-36,"d":"9.00E-36"},"G-protein-signaling modulator 3",".",".",".",".","pfam02188","GoLoco","GoLoco motif.","GO:0002690|positive regulation of leukocyte chemotaxis;GO:0006955|immune response;GO:0050729|positive regulation of inflammatory response;GO:0050790|regulation of catalytic activity;GO:1900017|positive regulation of cytokine production involved in inflammatory response;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;","GO:0030695|GTPase regulator activity;","K15838","GPSM3, AGS4; G-protein signaling modulator 3"]
["ENSRNOG00000015089",79,6.559106181,5,0.321652191,20.39192136,4.349925809,{"v":1.38202E-21,"d":"1.38E-21"},{"v":5.48526e-21,"d":"5.49E-21"},"up","yes","Mcoln2","protein_coding","chr2:235053816-235102702:+","gi|84781670|ref|NP_001034094.1|",2954,0,"mucolipin-2 [Rattus norvegicus]","gi|84781669|ref|NM_001039005.1|",2504,0,"Rattus norvegicus mucolipin 2 (Mcoln2), mRNA","Q8K595",1052,0,"Mucolipin-2",".",".",".",".","pfam08016","PKD_channel","Polycystin cation channel. This family contains the cation channel region of PKD1 and PKD2 proteins.","GO:0032722|positive regulation of chemokine production;GO:0051209|release of sequestered calcium ion into cytosol;GO:0071639|positive regulation of monocyte chemotactic protein-1 production;GO:0071642|positive regulation of macrophage inflammatory protein 1 alpha production;GO:0071651|positive regulation of chemokine (C-C motif) ligand 5 production;GO:1905517|macrophage migration;GO:1990266|neutrophil migration;GO:2000341|regulation of chemokine (C-X-C motif) ligand 2 production;GO:2000343|positive regulation of chemokine (C-X-C motif) ligand 2 production;","GO:0010008|endosome membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0055037|recycling endosome;","GO:0042802|identical protein binding;GO:0072345|NAADP-sensitive calcium-release channel activity;","K04993","MCOLN2, TRPML2; mucolipin 2"]
["ENSRNOG00000058714",81,6.725159503,6,0.385982629,17.42347711,4.122960658,{"v":1.62411E-21,"d":"1.62E-21"},{"v":6.42618e-21,"d":"6.43E-21"},"up","yes","Klre1","protein_coding","chr4:163033563-163041638:+","gi|32189318|ref|NP_852037.1|",960,{"v":1E-127,"d":"1.00E-127"},"killer cell lectin-like receptor, family E, member 1 [Rattus norvegicus]","gi|672051182|ref|XM_006237081.2|",927,0,"PREDICTED: Rattus norvegicus killer cell lectin-like receptor, family E, member 1 (Klre1), transcript variant X2, mRNA","Q80ZC8",374,{"v":5e-129,"d":"5.00E-129"},"Killer cell lectin-like receptor subfamily E member 1",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0002223|stimulatory C-type lectin receptor signaling pathway;GO:0002859|negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target;GO:0030101|natural killer cell activation;GO:0032729|positive regulation of interferon-gamma production;GO:0034260|negative regulation of GTPase activity;GO:0042267|natural killer cell mediated cytotoxicity;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;GO:2000502|negative regulation of natural killer cell chemotaxis;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;","GO:0004888|transmembrane signaling receptor activity;GO:0019903|protein phosphatase binding;GO:0030246|carbohydrate binding;GO:0038023|signaling receptor activity;GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000019907",344,28.56117122,193,12.41577457,2.30039383,1.201880874,{"v":2.21511E-21,"d":"2.22E-21"},{"v":8.73221e-21,"d":"8.73E-21"},"up","yes","Nfkbie","protein_coding","chr9:15436941-15450437:-","gi|40018590|ref|NP_954542.1|",1617,0,"NF-kappa-B inhibitor epsilon [Rattus norvegicus]","gi|84578882|dbj|AB197928.1|",1604,0,"Rattus norvegicus dsm-1 mRNA for D-serine modulator-1, complete cds","O54910",597,0,"NF-kappa-B inhibitor epsilon","SPAC926.04c",140,{"v":2E-46,"d":"2.00E-46"},"COG0326","pfam08449","UAA","UAA transporter family. This family includes transporters with a specificity for UDP-N-acetylglucosamine.","GO:0042942|D-serine transport;","GO:0001650|fibrillar center;GO:0005654|nucleoplasm;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0048471|perinuclear region of cytoplasm;","GO:0003674|molecular_function;","K05872","NFKBIE; NF-kappa-B inhibitor epsilon"]
["ENSRNOG00000019043",74,6.143972879,3,0.192991315,31.83548904,4.992564021,{"v":2.45074e-21,"d":"2.45E-21"},{"v":9.65515e-21,"d":"9.66E-21"},"up","yes","Pdcd1","protein_coding","chr9:94418791-94431937:-","gi|157817590|ref|NP_001100397.1|",1469,0,"programmed cell death protein 1 precursor [Rattus norvegicus]","gi|672066226|ref|XM_008767395.1|",1927,0,"PREDICTED: Rattus norvegicus programmed cell death 1 (Pdcd1), transcript variant X1, mRNA","Q02242",485,{"v":1E-166,"d":"1.00E-166"},"Programmed cell death protein 1",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000065780",194,16.10717214,74,4.760452426,3.383538097,1.758532633,{"v":2.72168e-21,"d":"2.72E-21"},{"v":1.06896e-20,"d":"1.07E-20"},"up","yes","ENSRNOG00000065780","protein_coding","chr20:3258430-3268369:+","gi|795465911|ref|XP_011889985.1|",343,{"v":1E-62,"d":"1.00E-62"},"PREDICTED: HLA class I histocompatibility antigen, B-14 alpha chain-like [Cercocebus atys]","gi|46237639|emb|BX883047.1|",3155,0,"Rattus norvegicus chromosome 20, major histocompatibility complex, assembled from 40 BACs, strain Brown Norway (BN/ssNHsd), RT1n haplotype; segment 6/11","P15978",188,{"v":3e-50,"d":"3.00E-50"},"Class I histocompatibility antigen, Non-RT1.A alpha-1 chain",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.",".",".",".",".","."]
["ENSRNOG00000005286",111,9.215959318,21,1.350939202,6.821890508,2.7701716,{"v":2.73175E-21,"d":"2.73E-21"},{"v":1.07226e-20,"d":"1.07E-20"},"up","yes","Coch","protein_coding","chr6:69031167-69045109:+","gi|149051203|gb|EDM03376.1|",2785,0,"coagulation factor C homolog (Limulus polyphemus) (predicted), isoform CRA_a [Rattus norvegicus]","gi|169642482|gb|BC160874.1|",2292,0,"Rattus norvegicus coagulation factor C homolog, cochlin (Limulus polyphemus), mRNA (cDNA clone MGC:188242 IMAGE:7367398), complete cds","Q62507",1066,0,"Cochlin",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0007605|sensory perception of sound;GO:0008150|biological_process;GO:0008360|regulation of cell shape;GO:0042742|defense response to bacterium;GO:0045089|positive regulation of innate immune response;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0031012|extracellular matrix;GO:0062023|collagen-containing extracellular matrix;","GO:0003674|molecular_function;GO:0005518|collagen binding;",".","."]
["ENSRNOG00000006860",105,8.717799355,18,1.157947887,7.528662948,2.912393672,{"v":3.38346E-21,"d":"3.38E-21"},{"v":1.32319E-20,"d":"1.32E-20"},"up","yes","Itk","protein_coding","chr10:30753344-30814685:-","gi|157818821|ref|NP_001102295.1|",3392,0,"tyrosine-protein kinase ITK/TSK [Rattus norvegicus]","gi|672067342|ref|XM_008767692.1|",4199,0,"PREDICTED: Rattus norvegicus IL2-inducible T-cell kinase (Itk), transcript variant X1, mRNA","Q03526",1276,0,"Tyrosine-protein kinase ITK/TSK",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001819|positive regulation of cytokine production;GO:0001865|NK T cell differentiation;GO:0002250|adaptive immune response;GO:0006468|protein phosphorylation;GO:0007202|activation of phospholipase C activity;GO:0035556|intracellular signal transduction;GO:0038083|peptidyl-tyrosine autophosphorylation;GO:0046629|gamma-delta T cell activation;GO:0050852|T cell receptor signaling pathway;GO:0050853|B cell receptor signaling pathway;","GO:0005634|nucleus;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;","GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0005524|ATP binding;GO:0046872|metal ion binding;","K07363","ITK; IL2-inducible T-cell kinase [EC:2.7.10.2]"]
["ENSRNOG00000019057",82,6.808186163,7,0.450313067,15.11878437,3.918270239,{"v":3.78763e-21,"d":"3.79E-21"},{"v":1.47764e-20,"d":"1.48E-20"},"up","yes","Prkcq","protein_coding","chr17:67246394-67378704:-","gi|454515948|ref|NP_001263650.1|",3775,0,"protein kinase C theta type [Rattus norvegicus]","gi|454515947|ref|NM_001276721.1|",3370,0,"Rattus norvegicus protein kinase C, theta (Prkcq), mRNA","Q9WTQ0",1454,0,"Protein kinase C theta type",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0001666|response to hypoxia;GO:0002376|immune system process;GO:0006355|regulation of transcription, DNA-templated;GO:0006468|protein phosphorylation;GO:0006509|membrane protein ectodomain proteolysis;GO:0006954|inflammatory response;GO:0007568|aging;GO:0009408|response to heat;GO:0009749|response to glucose;GO:0010389|regulation of G2/M transition of mitotic cell cycle;GO:0014070|response to organic cyclic compound;GO:0018105|peptidyl-serine phosphorylation;GO:0019229|regulation of vasoconstriction;GO:0030182|neuron differentiation;GO:0032212|positive regulation of telomere maintenance via telomerase;GO:0032740|positive regulation of interleukin-17 production;GO:0032743|positive regulation of interleukin-2 production;GO:0032753|positive regulation of interleukin-4 production;GO:0032868|response to insulin;GO:0035556|intracellular signal transduction;GO:0042102|positive regulation of T cell proliferation;GO:0042246|tissue regeneration;GO:0042307|positive regulation of protein import into nucleus;GO:0045730|respiratory burst;GO:0046627|negative regulation of insulin receptor signaling pathway;GO:0050714|positive regulation of protein secretion;GO:0050870|positive regulation of T cell activation;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051491|positive regulation of filopodium assembly;GO:0051496|positive regulation of stress fiber assembly;GO:0051973|positive regulation of telomerase activity;GO:0060326|cell chemotaxis;GO:0070233|negative regulation of T cell apoptotic process;GO:0090330|regulation of platelet aggregation;GO:1904355|positive regulation of telomere capping;GO:2000318|positive regulation of T-helper 17 type immune response;GO:2000570|positive regulation of T-helper 2 cell activation;","GO:0001772|immunological synapse;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016235|aggresome;GO:0031594|neuromuscular junction;GO:0034451|centriolar satellite;GO:0042383|sarcolemma;","GO:0004674|protein serine/threonine kinase activity;GO:0004697|protein kinase C activity;GO:0004698|calcium-dependent protein kinase C activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0046872|metal ion binding;","K18052","PRKCQ; novel protein kinase C theta type [EC:2.7.11.13]"]
["ENSRNOG00000021814",182,15.11085222,66,4.24580892,3.559004303,1.831473677,{"v":3.88022e-21,"d":"3.88E-21"},{"v":1.51284e-20,"d":"1.51E-20"},"up","yes","Tnfrsf25","protein_coding","chr5:162622075-162626341:+","gi|212549637|ref|NP_001131116.1|",1788,0,"tumor necrosis factor receptor superfamily member 25 precursor [Rattus norvegicus]","gi|212549636|ref|NM_001137644.1|",1626,0,"Rattus norvegicus tumor necrosis factor receptor superfamily, member 25 (Tnfrsf25), mRNA","Q93038",432,{"v":1e-145,"d":"1.00E-145"},"Tumor necrosis factor receptor superfamily member 25",".",".",".",".","pfam00531","Death","Death domain.","GO:0006915|apoptotic process;GO:0007165|signal transduction;","GO:0005886|plasma membrane;",".","K05160","TNFRSF25; tumor necrosis factor receptor superfamily member 25"]
["ENSRNOG00000036674",90,7.472399447,11,0.70763482,10.5596831,3.400494634,{"v":6.17709E-21,"d":"6.18E-21"},{"v":2.39086E-20,"d":"2.39E-20"},"up","yes","Cd7","protein_coding","chr10:106304056-106306967:-","gi|157819011|ref|NP_001100544.1|",1010,{"v":6e-135,"d":"6.00E-135"},"T-cell antigen CD7 precursor [Rattus norvegicus]","gi|298887746|emb|FQ233656.1|",971,0,"Rattus norvegicus TL0AEA60YP20 mRNA sequence","P50283",320,{"v":1E-107,"d":"1.00E-107"},"T-cell antigen CD7",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0002250|adaptive immune response;GO:0048873|homeostasis of number of cells within a tissue;","GO:0016021|integral component of membrane;","GO:0038023|signaling receptor activity;","K06457","CD7; T-cell surface glycoprotein CD7"]
["ENSRNOG00000020849",102,8.468719374,17,1.093617449,7.743767604,2.953035657,{"v":6.73204E-21,"d":"6.73E-21"},{"v":2.60407e-20,"d":"2.60E-20"},"up","yes","Hcst","protein_coding","chr1:85676979-85679012:-","gi|564327406|ref|XP_006228847.1|",291,{"v":3e-30,"d":"3.00E-30"},"PREDICTED: hematopoietic cell signal transducer isoform X1 [Rattus norvegicus]","gi|354796740|gb|JN961241.1|",278,{"v":5e-142,"d":"5.00E-142"},"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Hcst:tm1a(KOMP)Wtsi; transgenic","Q6X9T8",116,{"v":9e-32,"d":"9.00E-32"},"Hematopoietic cell signal transducer",".",".",".",".","pfam07213","DAP10","DAP10 membrane protein. This family consists of several mammalian DAP10 membrane proteins. In activated mouse natural killer (NK) cells, the NKG2D receptor associates with two intracellular adaptors, DAP10 and DAP12, which trigger phosphatidyl inositol 3 kinase (PI3K) and Syk family protein tyrosine kinases, respectively. It has been suggested that the DAP10-PI3K pathway is sufficient to initiate NKG2D-mediated killing of target cells.","GO:0006468|protein phosphorylation;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0050776|regulation of immune response;","GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0005102|signaling receptor binding;GO:0043548|phosphatidylinositol 3-kinase binding;","K07988","HCST, DAP10; hematopoietic cell signal transducer"]
["ENSRNOG00000017803",172,14.28058561,60,3.859826291,3.699800077,1.887447315,{"v":7.8238e-21,"d":"7.82E-21"},{"v":3.01726e-20,"d":"3.02E-20"},"up","yes","Apbb1ip","protein_coding","chr17:84982243-85033010:+","gi|281332190|ref|NP_001094047.1|",2357,0,"amyloid beta A4 precursor protein-binding family B member 1-interacting protein [Rattus norvegicus]","gi|281332189|ref|NM_001100577.1|",2455,0,"Rattus norvegicus amyloid beta precursor protein binding family B member 1 interacting protein (Apbb1ip), mRNA","Q8R5A3",649,0,"Amyloid beta A4 precursor protein-binding family B member 1-interacting protein",".",".",".",".","pfam00788","RA","Ras association (RalGDS/AF-6) domain. RasGTP effectors (in cases of AF6, canoe and RalGDS); putative RasGTP effectors in other cases. Recent evidence (not yet in MEDLINE) shows that some RA domains do NOT bind RasGTP. Predicted structure similar to that determined, and that of the RasGTP-binding domain of Raf kinase.","GO:0002291|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0007165|signal transduction;GO:0045785|positive regulation of cell adhesion;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0042101|T cell receptor complex;",".","K17704","APBB1IP, RIAM; amyloid beta A4 precursor protein-binding family B member 1-interacting protein"]
["ENSRNOG00000010266",125,10.37833257,30,1.929913146,5.377616391,2.426966845,{"v":9.0668e-21,"d":"9.07E-21"},{"v":3.48611e-20,"d":"3.49E-20"},"up","yes","Cd180","protein_coding","chr2:33855991-33899936:+","gi|157823329|ref|NP_001099875.1|",3199,0,"CD180 antigen precursor [Rattus norvegicus]","gi|157823328|ref|NM_001106405.1|",2566,0,"Rattus norvegicus CD180 molecule (Cd180), mRNA","Q62192",1090,0,"CD180 antigen",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.","GO:0002224|toll-like receptor signaling pathway;GO:0002322|B cell proliferation involved in immune response;GO:0031666|positive regulation of lipopolysaccharide-mediated signaling pathway;GO:0071222|cellular response to lipopolysaccharide;","GO:0005615|extracellular space;GO:0016021|integral component of membrane;GO:0031012|extracellular matrix;","GO:0004888|transmembrane signaling receptor activity;","K06555","CD180; CD180 antigen"]
["ENSRNOG00000017429",152,12.6200524,47,3.023530595,4.173945659,2.061411818,{"v":1.09308E-20,"d":"1.09E-20"},{"v":4.1827e-20,"d":"4.18E-20"},"up","yes","Lat","protein_coding","chr1:180936534-180941578:-","gi|13540669|ref|NP_110480.1|",829,{"v":3e-106,"d":"3.00E-106"},"linker for activation of T-cells family member 1 [Rattus norvegicus]","gi|13540668|ref|NM_030853.1|",1188,0,"Rattus norvegicus linker for activation of T cells (Lat), mRNA","O70601",323,{"v":1E-107,"d":"1.00E-107"},"Linker for activation of T-cells family member 1",".",".",".",".","pfam15234","LAT","Linker for activation of T-cells.","GO:0002250|adaptive immune response;GO:0002260|lymphocyte homeostasis;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007229|integrin-mediated signaling pathway;GO:0007265|Ras protein signal transduction;GO:0010467|gene expression;GO:0019722|calcium-mediated signaling;GO:0035556|intracellular signal transduction;GO:0043303|mast cell degranulation;GO:0045860|positive regulation of protein kinase activity;GO:0048872|homeostasis of number of cells;GO:0050863|regulation of T cell activation;","GO:0001772|immunological synapse;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0008180|COP9 signalosome;GO:0016021|integral component of membrane;","GO:0019901|protein kinase binding;GO:0030159|receptor signaling complex scaffold activity;","K07362","LAT; linker for activation of T cells"]
["ENSRNOG00000000528",326,27.06669133,182,11.70813975,2.311784101,1.20900667,{"v":1.60241e-20,"d":"1.60E-20"},{"v":6.09515e-20,"d":"6.10E-20"},"up","yes","Fgd2","protein_coding","chr20:7424790-7441603:+","gi|564397249|ref|XP_006256267.1|",3436,0,"PREDICTED: FYVE, RhoGEF and PH domain-containing protein 2 isoform X1 [Rattus norvegicus]","gi|672085676|ref|XM_006256205.2|",2784,0,"PREDICTED: Rattus norvegicus FYVE, RhoGEF and PH domain containing 2 (Fgd2), transcript variant X1, mRNA","Q8BY35",1247,0,"FYVE, RhoGEF and PH domain-containing protein 2",".",".",".",".","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0007010|cytoskeleton organization;GO:0043507|positive regulation of JUN kinase activity;GO:0046847|filopodium assembly;","GO:0001726|ruffle;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005769|early endosome;GO:0005856|cytoskeleton;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0046872|metal ion binding;GO:1901981|phosphatidylinositol phosphate binding;","K05721","FGD2; FYVE, RhoGEF and PH domain containing 2"]
["ENSRNOG00000013834",267,22.16811836,133,8.555948279,2.590959837,1.373486652,{"v":1.71438e-20,"d":"1.71E-20"},{"v":6.51334e-20,"d":"6.51E-20"},"up","yes","Svs5","protein_coding","chr3:152996146-152997756:+","gi|19424158|ref|NP_598200.1|",422,{"v":3E-49,"d":"3.00E-49"},"seminal vesicle secretory protein 5 precursor [Rattus norvegicus]","gi|672089715|ref|XM_008773873.1|",628,0,"PREDICTED: Rattus norvegicus seminal vesicle secretory protein 5 (LOC103694892), mRNA","P04812",165,{"v":4E-50,"d":"4.00E-50"},"Seminal vesicle secretory protein 5",".",".",".",".","pfam03038","Herpes_UL95","UL95 family. Members of this family, found in several herpesviruses, include EBV BGLF3 and other UL95 proteins (e.g. HCMV UL95, HVS-1 34, HSV6 U67). Their function is unknown.",".","GO:0005615|extracellular space;",".",".","."]
["ENSRNOG00000017680",117,9.714119281,26,1.672591393,5.807825703,2.537998158,{"v":1.76182e-20,"d":"1.76E-20"},{"v":6.68959e-20,"d":"6.69E-20"},"up","yes","Dennd2d","protein_coding","chr2:193973231-193992270:+","gi|672043761|ref|XP_008759619.1|",2574,0,"PREDICTED: DENN domain-containing protein 2D isoform X2 [Rattus norvegicus]","gi|672043760|ref|XM_008761397.1|",2323,0,"PREDICTED: Rattus norvegicus DENN/MADD domain containing 2D (Dennd2d), transcript variant X2, mRNA","Q91VV4",766,0,"DENN domain-containing protein 2D",".",".",".",".","pfam02141","DENN","DENN (AEX-3) domain. DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.","GO:0050790|regulation of catalytic activity;","GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0005085|guanyl-nucleotide exchange factor activity;","K20161","DENND2; DENN domain-containing protein 2"]
["ENSRNOG00000001079",238,19.7603452,110,7.0763482,2.79244953,1.481531206,{"v":1.78892e-20,"d":"1.79E-20"},{"v":6.78444e-20,"d":"6.78E-20"},"up","yes","Daglb","protein_coding","chr12:11059732-11102154:-","gi|157820071|ref|NP_001100590.1|",3247,0,"sn1-specific diacylglycerol lipase beta [Rattus norvegicus]","gi|157820070|ref|NM_001107120.1|",3019,0,"Rattus norvegicus diacylglycerol lipase, beta (Daglb), mRNA","P0C1S9",1203,0,"Sn1-specific diacylglycerol lipase beta",".",".",".",".","pfam01764","Lipase_3","Lipase (class 3).","GO:0001516|prostaglandin biosynthetic process;GO:0006629|lipid metabolic process;GO:0006690|icosanoid metabolic process;GO:0007216|G protein-coupled glutamate receptor signaling pathway;GO:0007405|neuroblast proliferation;GO:0010898|positive regulation of triglyceride catabolic process;GO:0016042|lipid catabolic process;GO:0019369|arachidonic acid metabolic process;GO:0022008|neurogenesis;GO:0042136|neurotransmitter biosynthetic process;GO:0050727|regulation of inflammatory response;GO:0071926|endocannabinoid signaling pathway;GO:0098921|retrograde trans-synaptic signaling by endocannabinoid;","GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0045211|postsynaptic membrane;","GO:0004806|triglyceride lipase activity;GO:0016298|lipase activity;GO:0046872|metal ion binding;","K13806","DAGL; sn1-specific diacylglycerol lipase [EC:3.1.1.116]"]
["ENSRNOG00000005731",404,33.54277085,251,16.14693998,2.07734536,1.054741085,{"v":1.99344e-20,"d":"1.99E-20"},{"v":7.55111e-20,"d":"7.55E-20"},"up","yes","Birc3","protein_coding","chr8:5000845-5015802:-","gi|347921974|ref|NP_076477.3|",3220,0,"baculoviral IAP repeat-containing protein 3 [Rattus norvegicus]","gi|347921973|ref|NM_023987.3|",2618,0,"Rattus norvegicus baculoviral IAP repeat-containing 3 (Birc3), mRNA","O08863",1049,0,"Baculoviral IAP repeat-containing protein 3",".",".",".",".","pfam00653","BIR","Inhibitor of Apoptosis domain. BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteristically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.","GO:0006915|apoptotic process;GO:0007283|spermatogenesis;GO:0016567|protein ubiquitination;GO:0031398|positive regulation of protein ubiquitination;GO:0042326|negative regulation of phosphorylation;GO:0042981|regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0051726|regulation of cell cycle;GO:0060544|regulation of necroptotic process;GO:0060546|negative regulation of necroptotic process;GO:0070266|necroptotic process;GO:0071356|cellular response to tumor necrosis factor;GO:1901222|regulation of NIK/NF-kappaB signaling;GO:1902916|positive regulation of protein polyubiquitination;GO:2000378|negative regulation of reactive oxygen species metabolic process;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0032991|protein-containing complex;GO:0045121|membrane raft;","GO:0004842|ubiquitin-protein transferase activity;GO:0016740|transferase activity;GO:0043027|cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0044877|protein-containing complex binding;GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;","K16060","BIRC2_3; baculoviral IAP repeat-containing protein 2/3"]
["ENSRNOG00000009465",75,6.226999539,5,0.321652191,19.35941901,4.274963752,{"v":2.08469e-20,"d":"2.08E-20"},{"v":7.88742e-20,"d":"7.89E-20"},"up","yes","Sfrp2","protein_coding","chr2:169089517-169097063:+","gi|635045300|ref|XP_007998238.1|",1569,0,"PREDICTED: secreted frizzled-related protein 2 [Chlorocebus sabaeus]","gi|189181699|ref|NM_001100700.1|",1976,0,"Rattus norvegicus secreted frizzled-related protein 2 (Sfrp2), mRNA","P97299",570,0,"Secreted frizzled-related protein 2",".",".",".",".","pfam01392","Fz","Fz domain. Also known as the CRD (cysteine rich domain), the C6 box in MuSK receptor. This domain of unknown function has been independently identified by several groups. The domain contains 10 conserved cysteines.","GO:0001569|branching involved in blood vessel morphogenesis;GO:0001756|somitogenesis;GO:0001843|neural tube closure;GO:0002063|chondrocyte development;GO:0003151|outflow tract morphogenesis;GO:0003214|cardiac left ventricle morphogenesis;GO:0006915|apoptotic process;GO:0007267|cell-cell signaling;GO:0007584|response to nutrient;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0008584|male gonad development;GO:0009410|response to xenobiotic stimulus;GO:0009952|anterior/posterior pattern specification;GO:0010629|negative regulation of gene expression;GO:0010667|negative regulation of cardiac muscle cell apoptotic process;GO:0010719|negative regulation of epithelial to mesenchymal transition;GO:0010950|positive regulation of endopeptidase activity;GO:0010975|regulation of neuron projection development;GO:0021915|neural tube development;GO:0030111|regulation of Wnt signaling pathway;GO:0030178|negative regulation of Wnt signaling pathway;GO:0030199|collagen fibril organization;GO:0030307|positive regulation of cell growth;GO:0030308|negative regulation of cell growth;GO:0030336|negative regulation of cell migration;GO:0030514|negative regulation of BMP signaling pathway;GO:0031668|cellular response to extracellular stimulus;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0033630|positive regulation of cell adhesion mediated by integrin;GO:0035567|non-canonical Wnt signaling pathway;GO:0036342|post-anal tail morphogenesis;GO:0042127|regulation of cell proliferation;GO:0042662|negative regulation of mesodermal cell fate specification;GO:0042733|embryonic digit morphogenesis;GO:0042981|regulation of apoptotic process;GO:0043065|positive regulation of apoptotic process;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043508|negative regulation of JUN kinase activity;GO:0045600|positive regulation of fat cell differentiation;GO:0045669|positive regulation of osteoblast differentiation;GO:0045766|positive regulation of angiogenesis;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046546|development of primary male sexual characteristics;GO:0048546|digestive tract morphogenesis;GO:0050680|negative regulation of epithelial cell proliferation;GO:0050732|negative regulation of peptidyl-tyrosine phosphorylation;GO:0051216|cartilage development;GO:0060028|convergent extension involved in axis elongation;GO:0060070|canonical Wnt signaling pathway;GO:0060349|bone morphogenesis;GO:0061056|sclerotome development;GO:0061185|negative regulation of dermatome development;GO:0071425|hematopoietic stem cell proliferation;GO:0071481|cellular response to X-ray;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0090175|regulation of establishment of planar polarity;GO:0090179|planar cell polarity pathway involved in neural tube closure;GO:0090244|Wnt signaling pathway involved in somitogenesis;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:1902042|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1902230|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:1904956|regulation of midbrain dopaminergic neuron differentiation;GO:2000035|regulation of stem cell division;GO:2000041|negative regulation of planar cell polarity pathway involved in axis elongation;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0062023|collagen-containing extracellular matrix;","GO:0001968|fibronectin binding;GO:0003674|molecular_function;GO:0005178|integrin binding;GO:0008047|enzyme activator activity;GO:0017147|Wnt-protein binding;GO:0048018|receptor ligand activity;GO:0061133|endopeptidase activator activity;","K02176","SFRP2; secreted frizzled-related protein 2"]
["ENSRNOG00000022094",180,14.94479889,67,4.310139358,3.467358629,1.793837062,{"v":2.22165E-20,"d":"2.22E-20"},{"v":8.39565e-20,"d":"8.40E-20"},"up","yes","Lacc1","protein_coding","chr15:52395183-52407545:-","gi|27663906|ref|XP_233749.1|",2306,0,"PREDICTED: laccase domain-containing protein 1 [Rattus norvegicus]","gi|672028748|ref|XM_001072262.4|",2190,0,"PREDICTED: Rattus norvegicus laccase (multicopper oxidoreductase) domain containing 1 (Lacc1), mRNA","Q8BZT9",780,0,"Laccase domain-containing protein 1","BS_ylmD",110,{"v":2e-25,"d":"2.00E-25"},"COG1496","pfam02578","Cu-oxidase_4","Multi-copper polyphenol oxidoreductase laccase. Laccases are multi-copper oxidoreductases able to oxidize a wide variety of phenolic and non-phenolic compounds and are widely distributed among both prokaryotes and eukaryotes. There are two main active catalytic sites with conserved histidines that are capable of binding four copper atoms.","GO:0002221|pattern recognition receptor signaling pathway;GO:0002720|positive regulation of cytokine production involved in immune response;GO:0030641|regulation of cellular pH;GO:0050727|regulation of inflammatory response;GO:0070431|nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:1900542|regulation of purine nucleotide metabolic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005777|peroxisome;GO:0005783|endoplasmic reticulum;","GO:0004000|adenosine deaminase activity;GO:0004731|purine-nucleoside phosphorylase activity;GO:0005507|copper ion binding;GO:0017061|S-methyl-5-thioadenosine phosphorylase activity;GO:0047975|guanosine phosphorylase activity;","K05810","LACC1, yfiH; purine-nucleoside/S-methyl-5'-thioadenosine phosphorylase / adenosine deaminase [EC:2.4.2.1 2.4.2.28 3.5.4.4]"]
["ENSRNOG00000052407",135,11.20859917,37,2.380226213,4.709047867,2.235435388,{"v":2.27743e-20,"d":"2.28E-20"},{"v":8.60136E-20,"d":"8.60E-20"},"up","yes","ENSRNOG00000052407","protein_coding","chrX:97722802-97761853:-","gi|56119141|ref|NP_001007799.1|",3414,0,"tyrosine-protein kinase BTK [Rattus norvegicus]","gi|298899306|emb|FQ215667.1|",2434,0,"Rattus norvegicus TL0ACA47YE13 mRNA sequence","P35991",1311,0,"Tyrosine-protein kinase BTK",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001805|positive regulation of type III hypersensitivity;GO:0001812|positive regulation of type I hypersensitivity;GO:0001818|negative regulation of cytokine production;GO:0002344|B cell affinity maturation;GO:0002553|histamine secretion by mast cell;GO:0006468|protein phosphorylation;GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0010033|response to organic substance;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0030889|negative regulation of B cell proliferation;GO:0034614|cellular response to reactive oxygen species;GO:0035556|intracellular signal transduction;GO:0046777|protein autophosphorylation;GO:0048469|cell maturation;GO:0050790|regulation of catalytic activity;GO:0050853|B cell receptor signaling pathway;GO:0071226|cellular response to molecule of fungal origin;GO:0098761|cellular response to interleukin-7;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0031410|cytoplasmic vesicle;GO:0045121|membrane raft;GO:0048471|perinuclear region of cytoplasm;","GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0005524|ATP binding;GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;GO:0016004|phospholipase activator activity;GO:0042802|identical protein binding;GO:0043274|phospholipase binding;GO:0046872|metal ion binding;","K07370","BTK; Bruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2]"]
["ENSRNOG00000008759",113,9.382012639,24,1.543930516,6.076706522,2.603289618,{"v":2.34712e-20,"d":"2.35E-20"},{"v":8.85936e-20,"d":"8.86E-20"},"up","yes","Csf3r","protein_coding","chr5:138301506-138317881:+","gi|672053656|ref|XP_008762225.1|",4381,0,"PREDICTED: granulocyte colony-stimulating factor receptor isoform X2 [Rattus norvegicus]","gi|672053663|ref|XM_008764007.1|",2113,0,"PREDICTED: Rattus norvegicus colony stimulating factor 3 receptor (granulocyte) (Csf3r), transcript variant X5, mRNA","P40223",1395,0,"Granulocyte colony-stimulating factor receptor",".",".",".",".","pfam06328","Lep_receptor_Ig","Ig-like C2-type domain. This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.","GO:0019221|cytokine-mediated signaling pathway;GO:0030593|neutrophil chemotaxis;GO:0045637|regulation of myeloid cell differentiation;GO:0097186|amelogenesis;","GO:0005575|cellular_component;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0043235|receptor complex;","GO:0003674|molecular_function;GO:0004896|cytokine receptor activity;GO:0019955|cytokine binding;GO:0051916|granulocyte colony-stimulating factor binding;","K05061","CSF3R, CD114; granulocyte colony-stimulating factor receptor"]
["ENSRNOG00000003298",141,11.70675913,41,2.637547966,4.438500944,2.150072504,{"v":2.80144e-20,"d":"2.80E-20"},{"v":1.05431E-19,"d":"1.05E-19"},"up","yes","Cd247","protein_coding","chr13:78043307-78122263:+","gi|328802705|ref|NP_740770.2|",880,{"v":1e-112,"d":"1.00E-112"},"T-cell surface glycoprotein CD3 zeta chain isoform 1 precursor [Rattus norvegicus]","gi|328802704|ref|NM_170789.2|",1707,0,"Rattus norvegicus Cd247 molecule (Cd247), transcript variant 1, mRNA","P24161",319,{"v":1e-104,"d":"1.00E-104"},"T-cell surface glycoprotein CD3 zeta chain",".",".",".",".","pfam11628","TCR_zetazeta","T-cell surface glycoprotein CD3 zeta chain. The incorporation of the zetazeta signalling module requires one basic TCR alpha and two zetazeta aspartic acid TM residues. The structure of the zetazeta(TM) dimer consists of a left-handed coiled coil with polar contacts. Two aspartic acids are critical for zetazeta dimerization and assembly with TCR.","GO:0007166|cell surface receptor signaling pathway;GO:0050852|T cell receptor signaling pathway;GO:0065003|protein-containing complex assembly;GO:2000010|positive regulation of protein localization to cell surface;","GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0042101|T cell receptor complex;GO:0042105|alpha-beta T cell receptor complex;","GO:0003674|molecular_function;GO:0004888|transmembrane signaling receptor activity;GO:0042802|identical protein binding;GO:1990782|protein tyrosine kinase binding;","K06453","CD3Z, CD247; CD3Z antigen, zeta polypeptide"]
["ENSRNOG00000013914",107,8.883852676,21,1.350939202,6.576056616,2.71722272,{"v":3.36621E-20,"d":"3.37E-20"},{"v":1.2624E-19,"d":"1.26E-19"},"up","yes","Gpr132","protein_coding","chr6:131924160-131942168:-","gi|564357535|ref|XP_006240723.1|",2445,0,"PREDICTED: probable G-protein coupled receptor 132 isoform X1 [Rattus norvegicus]","gi|672057201|ref|XM_006240661.2|",3186,0,"PREDICTED: Rattus norvegicus G protein-coupled receptor 132 (Gpr132), transcript variant X1, mRNA","Q9Z282",635,0,"Probable G-protein coupled receptor 132",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0000082|G1/S transition of mitotic cell cycle;GO:0007186|G protein-coupled receptor signaling pathway;GO:0010972|negative regulation of G2/M transition of mitotic cell cycle;","GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;","K08426","GPR132, G2A; G protein-coupled receptor 132"]
["ENSRNOG00000066332",68,5.645812916,1,0.064330438,87.76269951,6.455535997,{"v":7.31514e-20,"d":"7.32E-20"},{"v":2.70525E-19,"d":"2.71E-19"},"up","yes","ENSRNOG00000066332","protein_coding","chr17:45117812-45180027:+","gi|149029254|gb|EDL84521.1|",1389,{"v":2E-180,"d":"2.00E-180"},"rCG23113, isoform CRA_a [Rattus norvegicus]","gi|755544276|ref|XM_006516705.2|",1606,0,"PREDICTED: Mus musculus G protein-coupled receptor 141 (Gpr141), transcript variant X7, mRNA","Q7TQP0",510,{"v":1e-170,"d":"1.00E-170"},"Probable G-protein coupled receptor 141",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.",".",".",".",".","."]
["ENSRNOG00000008588",98,8.136612731,17,1.093617449,7.440090443,2.895320159,{"v":8.78039e-20,"d":"8.78E-20"},{"v":3.23589e-19,"d":"3.24E-19"},"up","yes","Batf","protein_coding","chr6:105353715-105376051:+","gi|148670929|gb|EDL02876.1|",818,{"v":3e-106,"d":"3.00E-106"},"basic leucine zipper transcription factor, ATF-like, partial [Mus musculus]","gi|672056489|ref|XM_008764758.1|",969,0,"PREDICTED: Rattus norvegicus basic leucine zipper transcription factor, ATF-like (Batf), transcript variant X1, mRNA","D4A7E1",219,{"v":1e-69,"d":"1.00E-69"},"Basic leucine zipper transcriptional factor ATF-like",".",".",".",".","pfam07716","bZIP_2","Basic region leucine zipper.","GO:0001819|positive regulation of cytokine production;GO:0002320|lymphoid progenitor cell differentiation;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006974|cellular response to DNA damage stimulus;GO:0008150|biological_process;GO:0030330|DNA damage response, signal transduction by p53 class mediator;GO:0042832|defense response to protozoan;GO:0043011|myeloid dendritic cell differentiation;GO:0045064|T-helper 2 cell differentiation;GO:0045190|isotype switching;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0060218|hematopoietic stem cell differentiation;GO:0072539|T-helper 17 cell differentiation;GO:0072540|T-helper 17 cell lineage commitment;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003700|DNA-binding transcription factor activity;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09034","BATF; ATF-like basic leucine zipper transcriptional factor"]
["ENSRNOG00000062707",67,5.562786255,2,0.128660876,43.23603579,5.434162347,{"v":9.13821e-20,"d":"9.14E-20"},{"v":3.36001e-19,"d":"3.36E-19"},"up","yes","ENSRNOG00000062707","lncRNA","chr2:51977201-51983724:-",".",".",".",".","gi|672041660|ref|XR_590924.1|",538,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102556643 (LOC102556643), transcript variant X4, ncRNA",".",".",".",".",".",".",".",".","pfam07793","DUF1631","Protein of unknown function (DUF1631). The members of this family are sequences derived from a group of hypothetical proteins expressed by certain bacterial species. The region concerned is approximately 440 amino acid residues in length.",".",".",".",".","."]
["ENSRNOG00000049052",370,30.71986439,225,14.47434859,2.122365936,1.085673425,{"v":1.13118E-19,"d":"1.13E-19"},{"v":4.14019e-19,"d":"4.14E-19"},"up","yes","Sgk3","protein_coding","chr5:9346040-9415476:-","gi|392340278|ref|XP_003754029.1|",2660,0,"PREDICTED: serine/threonine-protein kinase Sgk3 isoform X1 [Rattus norvegicus]","gi|672019030|ref|XM_003753981.3|",3166,0,"PREDICTED: Rattus norvegicus serum/glucocorticoid regulated kinase family, member 3 (Sgk3), transcript variant X1, mRNA","Q8R4V0",1026,0,"Serine/threonine-protein kinase Sgk3",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006468|protein phosphorylation;GO:0018105|peptidyl-serine phosphorylation;GO:0035556|intracellular signal transduction;GO:2001240|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;","GO:0005654|nucleoplasm;GO:0005769|early endosome;GO:0031410|cytoplasmic vesicle;GO:0043231|intracellular membrane-bounded organelle;GO:0055037|recycling endosome;","GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;GO:0015459|potassium channel regulator activity;GO:0035091|phosphatidylinositol binding;","K13304","SGK3; serum/glucocorticoid-regulated kinase 3 [EC:2.7.11.1]"]
["ENSRNOG00000005935",227,18.84705194,105,6.754696009,2.790214676,1.480376126,{"v":1.40206e-19,"d":"1.40E-19"},{"v":5.1024e-19,"d":"5.10E-19"},"up","yes","A3galt2","protein_coding","chr5:141107983-141115641:+","gi|19924055|ref|NP_612533.1|",1776,0,"alpha-1,3-galactosyltransferase 2 [Rattus norvegicus]","gi|40254730|ref|NM_138524.2|",1814,0,"Rattus norvegicus alpha 1,3-galactosyltransferase 2 (A3galt2), mRNA","A0A4Z3",688,0,"Alpha-1,3-galactosyltransferase 2",".",".",".",".","pfam03414","Glyco_transf_6","Glycosyltransferase family 6.","GO:0005975|carbohydrate metabolic process;GO:0006688|glycosphingolipid biosynthetic process;GO:0030259|lipid glycosylation;GO:0071287|cellular response to manganese ion;","GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;GO:0031982|vesicle;GO:0032580|Golgi cisterna membrane;","GO:0001962|alpha-1,3-galactosyltransferase activity;GO:0016757|transferase activity, transferring glycosyl groups;GO:0046872|metal ion binding;GO:0047276|N-acetyllactosaminide 3-alpha-galactosyltransferase activity;","K20736","A3GALT2; alpha-1,3-galactosyltransferase 2 [EC:2.4.1.87]"]
["ENSRNOG00000026965",418,34.7051441,269,17.30488787,2.005511065,1.003969926,{"v":1.46222e-19,"d":"1.46E-19"},{"v":5.31527e-19,"d":"5.32E-19"},"up","yes","Tmem140","protein_coding","chr4:63536168-63548455:+","gi|57527560|ref|NP_001009709.1|",664,{"v":1e-77,"d":"1.00E-77"},"transmembrane protein 140 [Rattus norvegicus]","gi|224458423|gb|AC103335.7|",2316,0,"Rattus norvegicus Mcs1 CH230-96K19 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q5M826",260,{"v":4E-79,"d":"4.00E-79"},"Transmembrane protein 140",".",".",".",".","pfam14985","TM140","TM140 protein family. This family of uncharacterized membrane proteins are called transmembrane protein 140. They are found in mammals.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000033234",237,19.67731854,113,7.269339515,2.706892215,1.436637443,{"v":1.50513E-19,"d":"1.51E-19"},{"v":5.46504e-19,"d":"5.47E-19"},"up","yes","Ccrl2","protein_coding","chr8:111034279-111036664:-","gi|157824077|ref|NP_001101661.1|",1990,0,"C-C chemokine receptor-like 2 [Rattus norvegicus]","gi|157824076|ref|NM_001108191.1|",1979,0,"Rattus norvegicus chemokine (C-C motif) receptor-like 2 (Ccrl2), mRNA","O35457",509,{"v":8E-175,"d":"8.00E-175"},"C-C chemokine receptor-like 2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0019722|calcium-mediated signaling;GO:0060326|cell chemotaxis;GO:0070098|chemokine-mediated signaling pathway;","GO:0005737|cytoplasm;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;","GO:0016493|C-C chemokine receptor activity;GO:0019957|C-C chemokine binding;GO:0042379|chemokine receptor binding;GO:0048020|CCR chemokine receptor binding;","K08373","CCRL2; C-C chemokine receptor-like 2"]
["ENSRNOG00000019660",66,5.479759595,2,0.128660876,42.59072182,5.412467276,{"v":1.74179E-19,"d":"1.74E-19"},{"v":6.31002e-19,"d":"6.31E-19"},"up","yes","Spib","protein_coding","chr1:95018947-95024780:-","gi|564328190|ref|XP_006229176.1|",1065,{"v":6e-135,"d":"6.00E-135"},"PREDICTED: transcription factor Spi-B isoform X4 [Rattus norvegicus]","gi|672036559|ref|XM_006229114.2|",2659,0,"PREDICTED: Rattus norvegicus Spi-B transcription factor (Spi-1/PU.1 related) (Spib), transcript variant X4, mRNA","Q5EBA3",398,{"v":5e-130,"d":"5.00E-130"},"Transcription factor Spi-B",".",".",".",".","pfam00178","Ets","Ets-domain.","GO:0002327|immature B cell differentiation;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0030154|cell differentiation;GO:0030225|macrophage differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09439","SPIB; transcription factor Spi-B"]
["ENSRNOG00000010603",66,5.479759595,1,0.064330438,85.18144364,6.412467276,{"v":2.37009e-19,"d":"2.37E-19"},{"v":8.54262e-19,"d":"8.54E-19"},"up","yes","Gzma","protein_coding","chr2:44740569-44752493:-","gi|149059360|gb|EDM10367.1|",1376,0,"granzyme A [Rattus norvegicus]","gi|23618882|ref|NM_153468.1|",771,0,"Rattus norvegicus granzyme A (Gzma), mRNA","P11032",411,{"v":1e-143,"d":"1.00E-143"},"Granzyme A","VC1649",87.4,{"v":2e-18,"d":"2.00E-18"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0009617|response to bacterium;GO:0032078|negative regulation of endodeoxyribonuclease activity;GO:0043065|positive regulation of apoptotic process;GO:0043392|negative regulation of DNA binding;GO:0051354|negative regulation of oxidoreductase activity;GO:0051603|proteolysis involved in cellular protein catabolic process;GO:0070269|pyroptosis;GO:1902483|cytotoxic T cell apoptotic process;","GO:0005634|nucleus;","GO:0004252|serine-type endopeptidase activity;GO:0008236|serine-type peptidase activity;GO:0042803|protein homodimerization activity;","K01352","GZMA; granzyme A [EC:3.4.21.78]"]
["ENSRNOG00000010666",66,5.479759595,1,0.064330438,85.18144364,6.412467276,{"v":2.37009e-19,"d":"2.37E-19"},{"v":8.54262e-19,"d":"8.54E-19"},"up","yes","Ccn5","protein_coding","chr3:152491220-152502636:+","gi|149042986|gb|EDL96560.1|",1126,{"v":4e-148,"d":"4.00E-148"},"WNT1 inducible signaling pathway protein 2 [Rattus norvegicus]","gi|13928801|ref|NM_031590.1|",1630,0,"Rattus norvegicus WNT1 inducible signaling pathway protein 2 (Wisp2), mRNA","Q9Z0G4",423,{"v":7e-144,"d":"7.00E-144"},"WNT1-inducible-signaling pathway protein 2",".",".",".",".","pfam00219","IGFBP","Insulin-like growth factor binding protein.","GO:0001558|regulation of cell growth;GO:0007155|cell adhesion;GO:0007165|signal transduction;GO:0008285|negative regulation of cell proliferation;GO:0060548|negative regulation of cell death;","GO:0002102|podosome;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0031012|extracellular matrix;","GO:0005178|integrin binding;GO:0005515|protein binding;GO:0005520|insulin-like growth factor binding;GO:0008201|heparin binding;","K23089","CCN5, WISP2; CCN family member 5"]
["ENSRNOG00000019110",66,5.479759595,1,0.064330438,85.18144364,6.412467276,{"v":2.37009e-19,"d":"2.37E-19"},{"v":8.54262e-19,"d":"8.54E-19"},"up","yes","Ocstamp","protein_coding","chr3:154132328-154136991:-","gi|672017742|ref|XP_008773843.1|",2232,0,"PREDICTED: osteoclast stimulatory transmembrane protein [Rattus norvegicus]","gi|672017741|ref|XM_008775621.1|",1829,0,"PREDICTED: Rattus norvegicus zinc finger protein 334 (Zfp334), mRNA","Q9D611",729,0,"Osteoclast stimulatory transmembrane protein",".",".",".",".","pfam07782","DC_STAMP","DC-STAMP-like protein. This is a family of sequences which are similar to a region of the dendritic cell-specific transmembrane protein (DC-STAMP). This is thought to be a novel receptor protein that shares no identity with other multimembrane-spanning proteins. It is thought to have seven putative transmembrane regions, two of which are found in the region featured in this family. DC-STAMP is also described as having potential N-linked glycosylation sites and a potential phosphorylation site for PKC, but these are not conserved throughout the family.","GO:0034241|positive regulation of macrophage fusion;GO:0045672|positive regulation of osteoclast differentiation;GO:0071356|cellular response to tumor necrosis factor;GO:0071391|cellular response to estrogen stimulus;GO:0072674|multinuclear osteoclast differentiation;GO:0090290|positive regulation of osteoclast proliferation;","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000046254",206,17.10349207,90,5.789739437,2.954103938,1.562720587,{"v":2.8608E-19,"d":"2.86E-19"},{"v":1.02708E-18,"d":"1.03E-18"},"up","yes","Adgre1","protein_coding","chr9:2242474-2398000:+","gi|56090594|ref|NP_001007558.1|",4972,0,"adhesion G protein-coupled receptor E2 precursor [Rattus norvegicus]","gi|56090593|ref|NM_001007557.1|",3226,0,"Rattus norvegicus adhesion G protein-coupled receptor E1 (Adgre1), mRNA","Q5Y4N8",1919,0,"Adhesion G protein-coupled receptor E2",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0002250|adaptive immune response;GO:0007166|cell surface receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0071944|cell periphery;","GO:0004930|G protein-coupled receptor activity;GO:0005509|calcium ion binding;","K04591","ADGRE1, EMR1; adhesion G protein-coupled receptor E1"]
["ENSRNOG00000031168",124,10.29530591,33,2.12290446,4.849632237,2.277875347,{"v":3.08134e-19,"d":"3.08E-19"},{"v":1.1044e-18,"d":"1.10E-18"},"up","yes","Arhgap15","protein_coding","chr3:27989633-28600265:+","gi|62078565|ref|NP_001013939.1|",2173,0,"rho GTPase-activating protein 15 [Rattus norvegicus]","gi|62078564|ref|NM_001013917.1|",1306,0,"Rattus norvegicus Rho GTPase activating protein 15 (Arhgap15), mRNA","Q6AYC5",841,0,"Rho GTPase-activating protein 15",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0007165|signal transduction;GO:0008360|regulation of cell shape;GO:0043087|regulation of GTPase activity;","GO:0005737|cytoplasm;GO:0016020|membrane;","GO:0005096|GTPase activator activity;","K20637","ARHGAP15; Rho GTPase-activating protein 15"]
["ENSRNOG00000002820",107,8.883852676,23,1.479600078,6.004225606,2.585978187,{"v":3.14627e-19,"d":"3.15E-19"},{"v":1.12577E-18,"d":"1.13E-18"},"up","yes","ENSRNOG00000002820","protein_coding","chr10:42615555-42623784:+","gi|14389303|ref|NP_113725.1|",1187,{"v":5e-159,"d":"5.00E-159"},"protein RoBo-1 precursor [Rattus norvegicus]","gi|14389302|ref|NM_031537.1|",1455,0,"Rattus norvegicus RoBo-1 (LOC24906), mRNA","O55006",461,{"v":2E-160,"d":"2.00E-160"},"Protein RoBo-1",".",".",".",".","pfam12749","Metallothio_Euk","Eukaryotic metallothionein. This is a family of eukaryotic metallothioneins.","GO:0046849|bone remodeling;","GO:0005576|extracellular region;",".",".","."]
["ENSRNOG00000026787",75,6.226999539,7,0.450313067,13.82815644,3.789536925,{"v":4.38265e-19,"d":"4.38E-19"},{"v":1.56118E-18,"d":"1.56E-18"},"up","yes","Disp2","protein_coding","chr3:105762305-105777800:+","gi|149022987|gb|EDL79881.1|",6099,0,"dispatched homolog 2 (Drosophila) (predicted), isoform CRA_f [Rattus norvegicus]","gi|672046546|ref|XM_006234756.2|",5952,0,"PREDICTED: Rattus norvegicus dispatched homolog 2 (Drosophila) (Disp2), transcript variant X1, mRNA","Q8CIP5",2201,0,"Protein dispatched homolog 2",".",".",".",".","pfam03176","MMPL","MMPL family. Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.",".","GO:0016021|integral component of membrane;",".","K24681","DISP2; protein dispatched 2"]
["ENSRNOG00000017485",116,9.631092621,29,1.865582707,5.162511736,2.368073156,{"v":6.9752e-19,"d":"6.98E-19"},{"v":2.4519E-18,"d":"2.45E-18"},"up","yes","Cd72","protein_coding","chr5:57697367-57704725:-","gi|62543519|ref|NP_001015016.1|",1653,0,"B-cell differentiation antigen CD72 [Rattus norvegicus]","gi|62543518|ref|NM_001015016.1|",1473,0,"Rattus norvegicus Cd72 molecule (Cd72), mRNA","P21855",396,{"v":4e-133,"d":"4.00E-133"},"B-cell differentiation antigen CD72",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type",".","GO:0005887|integral component of plasma membrane;","GO:0004888|transmembrane signaling receptor activity;","K06504","CD72; CD72 antigen"]
["ENSRNOG00000022565",178,14.77874557,71,4.567461111,3.235658764,1.694059468,{"v":9.6239e-19,"d":"9.62E-19"},{"v":3.36447e-18,"d":"3.36E-18"},"up","yes","Lrrc25","protein_coding","chr16:18806890-18813671:-","gi|62662417|ref|XP_573882.1|",1630,0,"PREDICTED: leucine-rich repeat-containing protein 25 isoform X1 [Rattus norvegicus]","gi|672029252|ref|XM_001070537.5|",3599,0,"PREDICTED: Rattus norvegicus leucine rich repeat containing 25 (Lrrc25), transcript variant X1, mRNA","Q8K1T1",424,{"v":1E-134,"d":"1.00E-134"},"Leucine-rich repeat-containing protein 25",".",".",".",".","pfam00019","TGF_beta","Transforming growth factor beta like domain.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000001302",151,12.53702574,52,3.345182786,3.747784962,1.906038177,{"v":1.04869e-18,"d":"1.05E-18"},{"v":3.6522e-18,"d":"3.65E-18"},"up","yes","Adora2a","protein_coding","chr20:13315853-13333386:-","gi|78126172|ref|NP_445746.3|",1930,0,"adenosine receptor A2a [Rattus norvegicus]","gi|675269485|ref|NM_053294.4|",2485,0,"Rattus norvegicus adenosine A2a receptor (Adora2a), mRNA","P30543",748,0,"Adenosine receptor A2a",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001963|synaptic transmission, dopaminergic;GO:0001973|adenosine receptor signaling pathway;GO:0001975|response to amphetamine;GO:0006355|regulation of transcription, DNA-templated;GO:0006469|negative regulation of protein kinase activity;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007205|protein kinase C-activating G protein-coupled receptor signaling pathway;GO:0007271|synaptic transmission, cholinergic;GO:0007626|locomotory behavior;GO:0008285|negative regulation of cell proliferation;GO:0009410|response to xenobiotic stimulus;GO:0014049|positive regulation of glutamate secretion;GO:0014057|positive regulation of acetylcholine secretion, neurotransmission;GO:0014061|regulation of norepinephrine secretion;GO:0031000|response to caffeine;GO:0032230|positive regulation of synaptic transmission, GABAergic;GO:0035249|synaptic transmission, glutamatergic;GO:0035810|positive regulation of urine volume;GO:0035815|positive regulation of renal sodium excretion;GO:0040013|negative regulation of locomotion;GO:0042311|vasodilation;GO:0042755|eating behavior;GO:0043116|negative regulation of vascular permeability;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043279|response to alkaloid;GO:0043524|negative regulation of neuron apoptotic process;GO:0045938|positive regulation of circadian sleep/wake cycle, sleep;GO:0046636|negative regulation of alpha-beta T cell activation;GO:0048143|astrocyte activation;GO:0048812|neuron projection morphogenesis;GO:0050714|positive regulation of protein secretion;GO:0050728|negative regulation of inflammatory response;GO:0051881|regulation of mitochondrial membrane potential;GO:0051899|membrane depolarization;GO:0051924|regulation of calcium ion transport;GO:0051968|positive regulation of synaptic transmission, glutamatergic;GO:0060079|excitatory postsynaptic potential;GO:0060080|inhibitory postsynaptic potential;GO:0060134|prepulse inhibition;GO:1900273|positive regulation of long-term synaptic potentiation;GO:2000300|regulation of synaptic vesicle exocytosis;GO:2001235|positive regulation of apoptotic signaling pathway;","GO:0000139|Golgi membrane;GO:0005882|intermediate filament;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0012505|endomembrane system;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0030673|axolemma;GO:0032279|asymmetric synapse;GO:0042734|presynaptic membrane;GO:0043025|neuronal cell body;GO:0045211|postsynaptic membrane;GO:0048786|presynaptic active zone;GO:0098978|glutamatergic synapse;GO:0099055|integral component of postsynaptic membrane;GO:0099056|integral component of presynaptic membrane;","GO:0001609|G protein-coupled adenosine receptor activity;GO:0005515|protein binding;GO:0019899|enzyme binding;GO:0031802|type 5 metabotropic glutamate receptor binding;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;GO:0051393|alpha-actinin binding;","K04266","ADORA2A, ADOR; adenosine receptor A2a"]
["ENSRNOG00000053494",67,5.562786255,4,0.257321753,21.61801789,4.434162347,{"v":1.05491E-18,"d":"1.05E-18"},{"v":3.67185e-18,"d":"3.67E-18"},"up","yes","Mcpt1l1","protein_coding","chr15:29903980-29906645:-","gi|546015|gb|AAB30269.1|",1217,{"v":1E-165,"d":"1.00E-165"},"protease 1, partial [Rattus sp.]","gi|298916395|emb|FQ219938.1|",1029,0,"Rattus norvegicus TL0ADA44YN02 mRNA sequence","P09650",473,{"v":6e-167,"d":"6.00E-167"},"Mast cell protease 1","VC1649",67.4,{"v":2e-11,"d":"2.00E-11"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;",".",".","K01329","CMA1; chymase [EC:3.4.21.39]"]
["ENSRNOG00000023881",80,6.642132842,10,0.643304382,10.32502347,3.368073156,{"v":1.19585e-18,"d":"1.20E-18"},{"v":4.15113e-18,"d":"4.15E-18"},"up","yes","Skap1","protein_coding","chr10:81425525-81732650:+","gi|67514574|ref|NP_775433.2|",1509,0,"src kinase-associated phosphoprotein 1 [Rattus norvegicus]","gi|241982901|gb|AC136178.3|",1314,0,"Rattus norvegicus CH230-435P16 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q4V7G1",585,0,"Src kinase-associated phosphoprotein 1",".",".",".",".","pfam00169","PH","PH domain. PH stands for pleckstrin homology.","GO:0001954|positive regulation of cell-matrix adhesion;GO:0002250|adaptive immune response;GO:0002821|positive regulation of adaptive immune response;GO:0033625|positive regulation of integrin activation;GO:0033634|positive regulation of cell-cell adhesion mediated by integrin;GO:0034116|positive regulation of heterotypic cell-cell adhesion;GO:0045785|positive regulation of cell adhesion;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050852|T cell receptor signaling pathway;GO:0072659|protein localization to plasma membrane;GO:1903039|positive regulation of leukocyte cell-cell adhesion;","GO:0001772|immunological synapse;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0032991|protein-containing complex;GO:0042101|T cell receptor complex;GO:0044853|plasma membrane raft;","GO:0005515|protein binding;GO:0019901|protein kinase binding;GO:0019903|protein phosphatase binding;GO:0042169|SH2 domain binding;GO:0044877|protein-containing complex binding;","K17699","SKAP1, SKAP55; src kinase associated phosphoprotein 1"]
["ENSRNOG00000020465",385,31.9652643,245,15.76095736,2.028129611,1.020149853,{"v":1.38923e-18,"d":"1.39E-18"},{"v":4.79896e-18,"d":"4.80E-18"},"up","yes","Ripk3","protein_coding","chr15:29283145-29292121:-","gi|564386074|ref|XP_006251990.1|",1965,0,"PREDICTED: receptor-interacting serine/threonine-protein kinase 3 isoform X1 [Rattus norvegicus]","gi|21326476|ref|NM_139342.1|",1748,0,"Rattus norvegicus receptor-interacting serine-threonine kinase 3 (Ripk3), mRNA","Q9Z2P5",761,0,"Receptor-interacting serine/threonine-protein kinase 3",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0001914|regulation of T cell mediated cytotoxicity;GO:0002819|regulation of adaptive immune response;GO:0006915|apoptotic process;GO:0007165|signal transduction;GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0010922|positive regulation of phosphatase activity;GO:0010940|positive regulation of necrotic cell death;GO:0032147|activation of protein kinase activity;GO:0032649|regulation of interferon-gamma production;GO:0033077|T cell differentiation in thymus;GO:0038061|NIK/NF-kappaB signaling;GO:0042981|regulation of apoptotic process;GO:0043029|T cell homeostasis;GO:0046006|regulation of activated T cell proliferation;GO:0046777|protein autophosphorylation;GO:0048535|lymph node development;GO:0048536|spleen development;GO:0048538|thymus development;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051351|positive regulation of ligase activity;GO:0051353|positive regulation of oxidoreductase activity;GO:0051607|defense response to virus;GO:0060545|positive regulation of necroptotic process;GO:0070235|regulation of activation-induced cell death of T cells;GO:0070266|necroptotic process;GO:0070301|cellular response to hydrogen peroxide;GO:0090312|positive regulation of protein deacetylation;GO:0097300|programmed necrotic cell death;GO:0097527|necroptotic signaling pathway;GO:0097528|execution phase of necroptosis;GO:1990000|amyloid fibril formation;GO:2000377|regulation of reactive oxygen species metabolic process;GO:2000379|positive regulation of reactive oxygen species metabolic process;GO:2000452|regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation;GO:2001244|positive regulation of intrinsic apoptotic signaling pathway;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0032991|protein-containing complex;","GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0004704|NF-kappaB-inducing kinase activity;GO:0005524|ATP binding;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;","K08847","RIPK3; receptor-interacting serine/threonine-protein kinase 3 [EC:2.7.11.1]"]
["ENSRNOG00000009385",193,16.02414548,84,5.403756808,2.965371324,1.568212771,{"v":3.0818E-18,"d":"3.08E-18"},{"v":1.05039E-17,"d":"1.05E-17"},"up","yes","Pik3cg","protein_coding","chr6:48766864-48802043:-","gi|392348758|ref|XP_003750188.1|",5918,0,"PREDICTED: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X2 [Rattus norvegicus]","gi|672055966|ref|XM_006240005.2|",6572,0,"PREDICTED: Rattus norvegicus phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma (Pik3cg), transcript variant X5, mRNA","Q9JHG7",2245,0,"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform","SPAC458.05",227,{"v":3e-60,"d":"3.00E-60"},"COG5032","pfam00613","PI3Ka","Phosphoinositide 3-kinase family, accessory domain (PIK domain). PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation.","GO:0001932|regulation of protein phosphorylation;GO:0002675|positive regulation of acute inflammatory response;GO:0003376|sphingosine-1-phosphate receptor signaling pathway;GO:0006468|protein phosphorylation;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0010595|positive regulation of endothelial cell migration;GO:0010897|negative regulation of triglyceride catabolic process;GO:0014065|phosphatidylinositol 3-kinase signaling;GO:0016310|phosphorylation;GO:0016477|cell migration;GO:0032252|secretory granule localization;GO:0035022|positive regulation of Rac protein signal transduction;GO:0036092|phosphatidylinositol-3-phosphate biosynthetic process;GO:0043085|positive regulation of catalytic activity;GO:0043406|positive regulation of MAP kinase activity;GO:0046854|phosphatidylinositol phosphorylation;GO:0048015|phosphatidylinositol-mediated signaling;GO:0051897|positive regulation of protein kinase B signaling;GO:0071320|cellular response to cAMP;GO:0097284|hepatocyte apoptotic process;GO:1903169|regulation of calcium ion transmembrane transport;GO:2000270|negative regulation of fibroblast apoptotic process;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005942|phosphatidylinositol 3-kinase complex;GO:0005943|phosphatidylinositol 3-kinase complex, class IA;GO:0005944|phosphatidylinositol 3-kinase complex, class IB;GO:0016020|membrane;","GO:0005524|ATP binding;GO:0016301|kinase activity;GO:0016303|1-phosphatidylinositol-3-kinase activity;GO:0035005|1-phosphatidylinositol-4-phosphate 3-kinase activity;GO:0042802|identical protein binding;GO:0046875|ephrin receptor binding;GO:0046934|phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0052742|phosphatidylinositol kinase activity;GO:0052812|phosphatidylinositol-3,4-bisphosphate 5-kinase activity;","K21289","PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [EC:2.7.1.153]"]
["ENSRNOG00000029670",259,21.50390508,137,8.813270031,2.43994624,1.286849361,{"v":3.56834e-18,"d":"3.57E-18"},{"v":1.21106e-17,"d":"1.21E-17"},"up","yes","RGD1564606","protein_coding","chr2:38451401-38453417:+","gi|530617155|ref|XP_005298314.1|",663,{"v":4e-83,"d":"4.00E-83"},"PREDICTED: 60S ribosomal protein L23a isoform X2 [Chrysemys picta bellii]","gi|672015379|ref|XR_599590.1|",560,0,"PREDICTED: Rattus norvegicus similar to 60S ribosomal protein L23a (RGD1564606), misc_RNA","P62752",259,{"v":2e-84,"d":"2.00E-84"},"60S ribosomal protein L23a","SPBC4F6.04",167,{"v":3E-49,"d":"3.00E-49"},"COG0089","pfam03939","Ribosomal_L23eN","Ribosomal protein L23, N-terminal domain. The N-terminal domain appears to be specific to the eukaryotic ribosomal proteins L25, L23, and L23a.","GO:0000027|ribosomal large subunit assembly;GO:0006412|translation;","GO:0022625|cytosolic large ribosomal subunit;","GO:0003735|structural constituent of ribosome;GO:0019843|rRNA binding;",".","."]
["ENSRNOG00000024264",144,11.95583912,49,3.152191471,3.792865765,1.923288314,{"v":4.14396e-18,"d":"4.14E-18"},{"v":1.40121E-17,"d":"1.40E-17"},"up","yes","Amz1","protein_coding","chr12:13891123-13909783:-","gi|114052795|ref|NP_001040557.1|",2368,0,"archaemetzincin-1 [Rattus norvegicus]","gi|672071996|ref|XM_006248933.2|",2333,0,"PREDICTED: Rattus norvegicus archaelysin family metallopeptidase 1 (Amz1), transcript variant X5, mRNA","Q400C9",914,0,"Archaemetzincin-1",".",".",".",".","pfam07998","Peptidase_M54","Peptidase family M54. This is a family of metallopeptidases. Two human proteins have been reported to degrade synthetic substrates and peptides.","GO:0006508|proteolysis;",".","GO:0008237|metallopeptidase activity;GO:0046872|metal ion binding;","K06974","amzA, AMZ2, AMZ1; archaemetzincin [EC:3.4.-.-]"]
["ENSRNOG00000042140",61,5.064626292,1,0.064330438,78.72830397,6.298810494,{"v":4.59888E-18,"d":"4.60E-18"},{"v":1.55257e-17,"d":"1.55E-17"},"up","yes","Eomes","protein_coding","chr8:118181777-118188316:+","gi|148677303|gb|EDL09250.1|",2908,0,"eomesodermin homolog (Xenopus laevis), isoform CRA_a, partial [Mus musculus]","gi|258645097|ref|NM_010136.3|",1903,0,"Mus musculus eomesodermin (Eomes), transcript variant 1, mRNA","O54839",1102,0,"Eomesodermin homolog",".",".",".",".","pfam00907","T-box","T-box. The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001706|endoderm formation;GO:0001707|mesoderm formation;GO:0001714|endodermal cell fate specification;GO:0001824|blastocyst development;GO:0001829|trophectodermal cell differentiation;GO:0002302|CD8-positive, alpha-beta T cell differentiation involved in immune response;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007420|brain development;GO:0007492|endoderm development;GO:0009653|anatomical structure morphogenesis;GO:0010002|cardioblast differentiation;GO:0010468|regulation of gene expression;GO:0019827|stem cell population maintenance;GO:0021772|olfactory bulb development;GO:0021796|cerebral cortex regionalization;GO:0021895|cerebral cortex neuron differentiation;GO:0022008|neurogenesis;GO:0030154|cell differentiation;GO:0030182|neuron differentiation;GO:0035914|skeletal muscle cell differentiation;GO:0043433|negative regulation of DNA-binding transcription factor activity;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048382|mesendoderm development;GO:0060706|cell differentiation involved in embryonic placenta development;GO:0060809|mesodermal to mesenchymal transition involved in gastrulation;","GO:0000785|chromatin;GO:0005634|nucleus;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0003682|chromatin binding;GO:0043565|sequence-specific DNA binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;GO:1990837|sequence-specific double-stranded DNA binding;","K10173","EOMES, TBR2; eomesodermin protein"]
["ENSRNOG00000066588",80,6.642132842,11,0.70763482,9.386384974,3.230569632,{"v":4.75506e-18,"d":"4.76E-18"},{"v":1.60107e-17,"d":"1.60E-17"},"up","yes","ENSRNOG00000066588","lncRNA","chr11:30683524-30696037:+","gi|149062621|gb|EDM13044.1|",139,2e-06,"rCG63645 [Rattus norvegicus]","gi|49615110|gb|AC120974.7|",8590,0,"Rattus norvegicus 11 BAC CH230-358O2 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam05030","SSXT","SSXT protein (N-terminal region). The SSXT or SS18 protein is involved in synovial sarcoma in humans. A SYT-SSX fusion gene resulting from the chromosomal translocation t(X;18) (p11;q11) is characteristic of synovial sarcomas. This translocation fuses the SSXT (SYT) gene from chromosome 18 to either of two homologous genes at Xp11, SSX1 or SSX2.",".",".",".",".","."]
["ENSRNOG00000013689",324,26.90063801,194,12.48010501,2.155481704,1.108010317,{"v":5.92956e-18,"d":"5.93E-18"},{"v":1.99025E-17,"d":"1.99E-17"},"up","yes","Vps18","protein_coding","chr3:106279425-106291964:+","gi|157817523|ref|NP_001099969.1|",5032,0,"vacuolar protein sorting-associated protein 18 homolog [Rattus norvegicus]","gi|197927321|ref|NM_001106499.2|",3774,0,"Rattus norvegicus VPS18 CORVET/HOPS core subunit (Vps18), mRNA","Q8R307",1910,0,"Vacuolar protein sorting-associated protein 18 homolog",".",".",".",".","pfam05131","Pep3_Vps18","Pep3/Vps18/deep orange family. This region is found in a number of protein identified as involved in golgi function and vacuolar sorting. The molecular function of this region is unknown. The members of this family contain a C-terminal ring finger domain.","GO:0006886|intracellular protein transport;GO:0006904|vesicle docking involved in exocytosis;GO:0007032|endosome organization;GO:0007033|vacuole organization;GO:0007040|lysosome organization;GO:0008333|endosome to lysosome transport;GO:0016567|protein ubiquitination;GO:0033147|negative regulation of intracellular estrogen receptor signaling pathway;GO:0046718|viral entry into host cell;GO:0048284|organelle fusion;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0005764|lysosome;GO:0005768|endosome;GO:0005769|early endosome;GO:0005770|late endosome;GO:0005884|actin filament;GO:0030123|AP-3 adaptor complex;GO:0030897|HOPS complex;GO:0033263|CORVET complex;GO:0098793|presynapse;GO:0098978|glutamatergic synapse;","GO:0003779|actin binding;GO:0005515|protein binding;GO:0019905|syntaxin binding;GO:0030674|protein binding, bridging;GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;","K20181","VPS18, PEP3; vacuolar protein sorting-associated protein 18"]
["ENSRNOG00000005342",182,15.11085222,77,4.95344374,3.050575117,1.609081256,{"v":6.9488e-18,"d":"6.95E-18"},{"v":2.3226E-17,"d":"2.32E-17"},"up","yes","Rassf5","protein_coding","chr13:42637549-42703024:-","gi|25742807|ref|NP_062238.1|",1904,0,"ras association domain-containing protein 5 [Rattus norvegicus]","gi|2459832|gb|AF002251.1|AF002251",3406,0,"Rattus norvegicus Maxp1 mRNA, complete cds","O35141",738,0,"Ras association domain-containing protein 5",".",".",".",".","pfam00788","RA","Ras association (RalGDS/AF-6) domain. RasGTP effectors (in cases of AF6, canoe and RalGDS); putative RasGTP effectors in other cases. Recent evidence (not yet in MEDLINE) shows that some RA domains do NOT bind RasGTP. Predicted structure similar to that determined, and that of the RasGTP-binding domain of Raf kinase.","GO:0006915|apoptotic process;GO:0007165|signal transduction;GO:0008285|negative regulation of cell proliferation;GO:0031398|positive regulation of protein ubiquitination;GO:0035556|intracellular signal transduction;GO:0042981|regulation of apoptotic process;GO:1900180|regulation of protein localization to nucleus;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005874|microtubule;","GO:0031267|small GTPase binding;GO:0042802|identical protein binding;GO:0046872|metal ion binding;","K08015","RASSF5, RAPL; Ras association domain-containing protein 5"]
["ENSRNOG00000020505",305,25.32313146,178,11.450818,2.211469213,1.145005158,{"v":7.88252e-18,"d":"7.88E-18"},{"v":2.62919e-17,"d":"2.63E-17"},"up","yes","Map4k1","protein_coding","chr1:84271069-84292493:+","gi|157819825|ref|NP_001099713.1|",3674,0,"mitogen-activated protein kinase kinase kinase kinase 1 [Rattus norvegicus]","gi|157819824|ref|NM_001106243.1|",2699,0,"Rattus norvegicus mitogen activated protein kinase kinase kinase kinase 1 (Map4k1), mRNA","P70218",1360,0,"Mitogen-activated protein kinase kinase kinase kinase 1",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006468|protein phosphorylation;GO:0007254|JNK cascade;GO:0008150|biological_process;GO:0008283|cell proliferation;GO:0018105|peptidyl-serine phosphorylation;GO:0035556|intracellular signal transduction;GO:0046777|protein autophosphorylation;GO:1904628|cellular response to phorbol 13-acetate 12-myristate;","GO:0005575|cellular_component;","GO:0003674|molecular_function;GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;GO:0008349|MAP kinase kinase kinase kinase activity;","K04408","MAP4K1, HPK1; mitogen-activated protein kinase kinase kinase kinase 1 [EC:2.7.11.1]"]
["ENSRNOG00000021018",64,5.313706274,4,0.257321753,20.65004694,4.368073156,{"v":8.07657e-18,"d":"8.08E-18"},{"v":2.69231e-17,"d":"2.69E-17"},"up","yes","ENSRNOG00000021018","protein_coding","chr1:203468097-203475889:+","gi|293344572|ref|XP_001071505.2|",1049,{"v":1e-140,"d":"1.00E-140"},"PREDICTED: basic leucine zipper transcriptional factor ATF-like 2 isoform X3 [Rattus norvegicus]","gi|672014615|ref|XM_001071505.4|",880,0,"PREDICTED: Rattus norvegicus basic leucine zipper transcription factor, ATF-like 2 (Batf2), transcript variant X4, mRNA","Q8R1H8",318,{"v":2e-106,"d":"2.00E-106"},"Basic leucine zipper transcriptional factor ATF-like 2",".",".",".",".","pfam02183","HALZ","Homeobox associated leucine zipper.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0042832|defense response to protozoan;GO:0043011|myeloid dendritic cell differentiation;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;","K09034","BATF; ATF-like basic leucine zipper transcriptional factor"]
["ENSRNOG00000015505",188,15.60901218,82,5.275095931,2.959000629,1.565110003,{"v":9.28582e-18,"d":"9.29E-18"},{"v":3.08439E-17,"d":"3.08E-17"},"up","yes","Mfap5","protein_coding","chr4:155727925-155750458:+","gi|157821273|ref|NP_001102114.1|",723,{"v":3e-91,"d":"3.00E-91"},"microfibrillar-associated protein 5 precursor [Rattus norvegicus]","gi|157821272|ref|NM_001108644.1|",642,0,"Rattus norvegicus microfibrillar associated protein 5 (Mfap5), mRNA","Q9QZJ6",268,{"v":7e-87,"d":"7.00E-87"},"Microfibrillar-associated protein 5",".",".",".",".","pfam05507","MAGP","Microfibril-associated glycoprotein (MAGP). This family consists of several mammalian microfibril-associated glycoprotein (MAGP) 1 and 2 proteins. MAGP1 and 2 are components of elastic fibres. MAGP-1 has been proposed to bind a C-terminal region of tropoelastin, the soluble precursor of elastin. MAGP-2 was found to interact with fibrillin-1 and -2, as well as fibulin-1, another component of elastic fibres this suggests that MAGP-2 may be important in the assembly of microfibrils.","GO:0048048|embryonic eye morphogenesis;GO:0060216|definitive hemopoiesis;GO:0097435|supramolecular fiber organization;","GO:0001527|microfibril;GO:0005576|extracellular region;GO:0031012|extracellular matrix;",".","K25410","MFAP5; microfibrillar-associated protein 5"]
["ENSRNOG00000054764",124,10.29530591,37,2.380226213,4.325347671,2.112816101,{"v":1.15456E-17,"d":"1.15E-17"},{"v":3.82704e-17,"d":"3.83E-17"},"up","yes","Flt3","protein_coding","chr12:7623930-7699474:+","gi|281371429|ref|NP_001094292.1|",5373,0,"receptor-type tyrosine-protein kinase FLT3 precursor [Rattus norvegicus]","gi|689971733|ref|NM_001100822.2|",3655,0,"Rattus norvegicus fms-related tyrosine kinase 3 (Flt3), mRNA","Q00342",1880,0,"Receptor-type tyrosine-protein kinase FLT3",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001776|leukocyte homeostasis;GO:0001934|positive regulation of protein phosphorylation;GO:0002318|myeloid progenitor cell differentiation;GO:0002320|lymphoid progenitor cell differentiation;GO:0002328|pro-B cell differentiation;GO:0002572|pro-T cell differentiation;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007275|multicellular organism development;GO:0008285|negative regulation of cell proliferation;GO:0009791|post-embryonic development;GO:0010243|response to organonitrogen compound;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0019221|cytokine-mediated signaling pathway;GO:0019882|antigen processing and presentation;GO:0030097|hemopoiesis;GO:0030098|lymphocyte differentiation;GO:0030183|B cell differentiation;GO:0031100|animal organ regeneration;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032727|positive regulation of interferon-alpha production;GO:0032729|positive regulation of interferon-gamma production;GO:0032735|positive regulation of interleukin-12 production;GO:0033674|positive regulation of kinase activity;GO:0035726|common myeloid progenitor cell proliferation;GO:0036145|dendritic cell homeostasis;GO:0040018|positive regulation of multicellular organism growth;GO:0045578|negative regulation of B cell differentiation;GO:0046651|lymphocyte proliferation;GO:0046777|protein autophosphorylation;GO:0048535|lymph node development;GO:0048536|spleen development;GO:0048873|homeostasis of number of cells within a tissue;GO:0071345|cellular response to cytokine stimulus;GO:0071385|cellular response to glucocorticoid stimulus;GO:0097028|dendritic cell differentiation;GO:0098586|cellular response to virus;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0032991|protein-containing complex;GO:0043235|receptor complex;","GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004896|cytokine receptor activity;GO:0005524|ATP binding;GO:0019838|growth factor binding;GO:0031625|ubiquitin protein ligase binding;GO:0035259|glucocorticoid receptor binding;GO:0043548|phosphatidylinositol 3-kinase binding;GO:0043621|protein self-association;GO:0044877|protein-containing complex binding;","K05092","FLT3, FLK2, CD135; fms-related tyrosine kinase 3 [EC:2.7.10.1]"]
["ENSRNOG00000005872",371,30.80289105,238,15.31064429,2.011861191,1.008530769,{"v":1.17185E-17,"d":"1.17E-17"},{"v":3.88035e-17,"d":"3.88E-17"},"up","yes","Tcf7","protein_coding","chr10:36423445-36453535:-","gi|564312700|ref|XP_006220728.1|",1649,0,"PREDICTED: transcription factor 7 isoform X2 [Rattus norvegicus]","gi|672024748|ref|XM_006220666.2|",3071,0,"PREDICTED: Rattus norvegicus transcription factor 7 (T-cell specific, HMG-box) (Tcf7), transcript variant X2, mRNA","Q00417",625,0,"Transcription factor 7",".",".",".",".","pfam08347","CTNNB1_binding","N-terminal CTNNB1 binding. This region tends to appear at the N-terminus of proteins also containing DNA-binding HMG (high mobility group) boxes (pfam00505) and appears to bind the armadillo repeat of CTNNB1 (beta-catenin), forming a stable complex. Signaling by Wnt through TCF/LCF is involved in developmental patterning, induction of neural tissues, cell fate decisions and stem cell differentiation. Isoforms of HMG T-cell factors lacking the N-terminal CTNNB1-binding domain cannot fulfill their role as transcriptional activators in T-cell differentiation.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008150|biological_process;GO:0021915|neural tube development;GO:0030538|embryonic genitalia morphogenesis;GO:0033153|T cell receptor V(D)J recombination;GO:0042127|regulation of cell proliferation;GO:0042492|gamma-delta T cell differentiation;GO:0044336|canonical Wnt signaling pathway involved in negative regulation of apoptotic process;GO:0045586|regulation of gamma-delta T cell differentiation;GO:0046632|alpha-beta T cell differentiation;GO:0048557|embryonic digestive tract morphogenesis;GO:0048619|embryonic hindgut morphogenesis;GO:0060070|canonical Wnt signaling pathway;GO:0071353|cellular response to interleukin-4;","GO:0000791|euchromatin;GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0016604|nuclear body;GO:1990907|beta-catenin-TCF complex;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001217|bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0008013|beta-catenin binding;GO:1990837|sequence-specific double-stranded DNA binding;","K02620","TCF7, TCF-1; transcription factor 7"]
["ENSRNOG00000003064",139,11.54070581,47,3.023530595,3.816963464,1.932425377,{"v":1.23329E-17,"d":"1.23E-17"},{"v":4.07957e-17,"d":"4.08E-17"},"up","yes","Bst1","protein_coding","chr14:67252998-67270180:-","gi|13540658|ref|NP_110475.1|",1366,0,"ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 precursor [Rattus norvegicus]","gi|74208693|dbj|AK164028.1|",994,0,"Mus musculus 7 days embryo whole body cDNA, RIKEN full-length enriched library, clone:C430019G14 product:bone marrow stromal cell antigen 1, full insert sequence","Q63072",529,0,"ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2",".",".",".",".","pfam02267","Rib_hydrolayse","ADP-ribosyl cyclase. ADP-ribosyl cyclase EC:3.2.2.5 (also know as cyclic ADP-ribose hydrolase or CD38) synthesizes cyclic-ADP ribose, a second messenger for glucose-induced insulin secretion.","GO:0001952|regulation of cell-matrix adhesion;GO:0008150|biological_process;GO:0008284|positive regulation of cell proliferation;GO:0030890|positive regulation of B cell proliferation;GO:0032956|regulation of actin cytoskeleton organization;GO:0050727|regulation of inflammatory response;GO:0050730|regulation of peptidyl-tyrosine phosphorylation;GO:0050848|regulation of calcium-mediated signaling;GO:0090022|regulation of neutrophil chemotaxis;","GO:0001931|uropod;GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0019898|extrinsic component of membrane;GO:0031225|anchored component of membrane;","GO:0003674|molecular_function;GO:0003953|NAD+ nucleosidase activity;GO:0016740|transferase activity;GO:0016849|phosphorus-oxygen lyase activity;GO:0050135|NAD(P)+ nucleosidase activity;GO:0061809|NAD+ nucleotidase, cyclic ADP-ribose generating;GO:0061811|ADP-ribosyl cyclase activity;GO:0061812|cyclic ADP-ribose hydrolase;","K18152","BST1, CD157; ADP-ribosyl cyclase 2 [EC:3.2.2.6 2.4.99.20]"]
["ENSRNOG00000009427",84,6.974239484,14,0.900626135,7.743767604,2.953035657,{"v":1.73523E-17,"d":"1.74E-17"},{"v":5.69863e-17,"d":"5.70E-17"},"up","yes","Tbx21","protein_coding","chr10:82082322-82098831:-","gi|157824180|ref|NP_001100513.1|",2493,0,"T-box transcription factor TBX21 [Rattus norvegicus]","gi|157824179|ref|NM_001107043.1|",2428,0,"Rattus norvegicus T-box 21 (Tbx21), mRNA","Q9JKD8",909,0,"T-box transcription factor TBX21",".",".",".",".","pfam00907","T-box","T-box. The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001708|cell fate specification;GO:0006357|regulation of transcription by RNA polymerase II;GO:0009615|response to virus;GO:0010628|positive regulation of gene expression;GO:0030217|T cell differentiation;GO:0032703|negative regulation of interleukin-2 production;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045580|regulation of T cell differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0048304|positive regulation of isotype switching to IgG isotypes;GO:0050776|regulation of immune response;GO:0071310|cellular response to organic substance;GO:0072676|lymphocyte migration;GO:2000320|negative regulation of T-helper 17 cell differentiation;GO:2000329|negative regulation of T-helper 17 cell lineage commitment;GO:2000552|negative regulation of T-helper 2 cell cytokine production;","GO:0005634|nucleus;GO:0043025|neuronal cell body;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K10166","TBX21; T-box protein 21"]
["ENSRNOG00000009260",147,12.2049191,53,3.409513224,3.579666156,1.839825046,{"v":1.79329e-17,"d":"1.79E-17"},{"v":5.88629e-17,"d":"5.89E-17"},"up","yes","Cnr2","protein_coding","chr5:148125604-148151548:+","gi|255918134|ref|NP_001157614.1|",1833,0,"cannabinoid receptor 2 isoform 1 [Rattus norvegicus]","gi|694872628|ref|NM_001164143.3|",3300,0,"Rattus norvegicus cannabinoid receptor 2 (Cnr2), transcript variant 1, mRNA","Q9QZN9",710,0,"Cannabinoid receptor 2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001975|response to amphetamine;GO:0006954|inflammatory response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0019222|regulation of metabolic process;GO:0019233|sensory perception of pain;GO:0030595|leukocyte chemotaxis;GO:0032229|negative regulation of synaptic transmission, GABAergic;GO:0032496|response to lipopolysaccharide;GO:0033004|negative regulation of mast cell activation;GO:0038171|cannabinoid signaling pathway;GO:0045759|negative regulation of action potential;GO:0050728|negative regulation of inflammatory response;GO:0051001|negative regulation of nitric-oxide synthase activity;","GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043204|perikaryon;","GO:0004930|G protein-coupled receptor activity;GO:0004949|cannabinoid receptor activity;","K04278","CNR2; cannabinoid receptor 2"]
["ENSRNOG00000024923",291,24.16075821,168,10.80751362,2.235551957,1.160631076,{"v":2.01044e-17,"d":"2.01E-17"},{"v":6.57544e-17,"d":"6.58E-17"},"up","yes","Nnat","protein_coding","chr3:146226407-146228834:+","gi|568915755|ref|XP_006498964.1|",368,{"v":2e-63,"d":"2.00E-63"},"PREDICTED: neuronatin isoform X1 [Mus musculus]","gi|399498578|ref|NR_073089.1|",1309,0,"Rattus norvegicus neuronatin (Nnat), transcript variant 4, non-coding RNA","Q62649",122,{"v":2e-32,"d":"2.00E-32"},"Neuronatin",".",".",".",".","pfam03141","Methyltransf_29","Putative S-adenosyl-L-methionine-dependent methyltransferase. This family is a putative S-adenosyl-L-methionine (SAM)-dependent methyltransferase.","GO:0007420|brain development;GO:0009749|response to glucose;GO:0030182|neuron differentiation;GO:0032024|positive regulation of insulin secretion;GO:0032880|regulation of protein localization;","GO:0005737|cytoplasm;",".",".","."]
["ENSRNOG00000043478",81,6.725159503,13,0.836295696,8.041604819,3.007483441,{"v":3.42483E-17,"d":"3.42E-17"},{"v":1.11387e-16,"d":"1.11E-16"},"up","yes","AABR07006142.1","protein_coding","chr2:85011149-85049805:+","gi|672073888|ref|XP_008767726.1|",1306,{"v":2E-176,"d":"2.00E-176"},"PREDICTED: tyrosine-protein phosphatase non-receptor type substrate 1-like isoform X2 [Rattus norvegicus]","gi|672073889|ref|XM_003751228.3|",818,0,"PREDICTED: Rattus norvegicus tyrosine-protein phosphatase non-receptor type substrate 1-like (LOC100909964), transcript variant X3, mRNA","P97797",188,{"v":7e-52,"d":"7.00E-52"},"Tyrosine-protein phosphatase non-receptor type substrate 1",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000028436",101,8.385692713,24,1.543930516,5.431392555,2.441322138,{"v":3.4544e-17,"d":"3.45E-17"},{"v":1.12292e-16,"d":"1.12E-16"},"up","yes","Rprml","protein_coding","chr10:88560248-88561252:+","gi|85701722|ref|NP_001028384.1|",606,{"v":2e-75,"d":"2.00E-75"},"reprimo-like protein [Mus musculus]","gi|157823288|ref|NM_001109481.1|",1005,0,"Rattus norvegicus reprimo-like (Rprml), mRNA","Q3URD2",238,{"v":8e-77,"d":"8.00E-77"},"Reprimo-like protein",".",".",".",".","pfam15402","Spc7_N","N-terminus of kinetochore NMS complex subunit Spc7.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000008223",204,16.93743875,97,6.240052504,2.714310294,1.440585656,{"v":4.15579E-17,"d":"4.16E-17"},{"v":1.34341E-16,"d":"1.34E-16"},"up","yes","Cnr1","protein_coding","chr5:48408574-48435099:+","gi|6978673|ref|NP_036916.1|",2480,0,"cannabinoid receptor 1 [Rattus norvegicus]","gi|284055292|ref|NM_012784.4|",5435,0,"Rattus norvegicus cannabinoid receptor 1 (brain) (Cnr1), mRNA","P20272",959,0,"Cannabinoid receptor 1",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0002866|positive regulation of acute inflammatory response to antigenic stimulus;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007188|adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007283|spermatogenesis;GO:0007413|axonal fasciculation;GO:0007568|aging;GO:0007584|response to nutrient;GO:0007611|learning or memory;GO:0007613|memory;GO:0010976|positive regulation of neuron projection development;GO:0014063|negative regulation of serotonin secretion;GO:0019216|regulation of lipid metabolic process;GO:0019222|regulation of metabolic process;GO:0019233|sensory perception of pain;GO:0031622|positive regulation of fever generation;GO:0031999|negative regulation of fatty acid beta-oxidation;GO:0032228|regulation of synaptic transmission, GABAergic;GO:0032496|response to lipopolysaccharide;GO:0033004|negative regulation of mast cell activation;GO:0033602|negative regulation of dopamine secretion;GO:0035094|response to nicotine;GO:0038171|cannabinoid signaling pathway;GO:0042220|response to cocaine;GO:0042593|glucose homeostasis;GO:0043065|positive regulation of apoptotic process;GO:0043271|negative regulation of ion transport;GO:0043278|response to morphine;GO:0045471|response to ethanol;GO:0045759|negative regulation of action potential;GO:0045776|negative regulation of blood pressure;GO:0045777|positive regulation of blood pressure;GO:0050796|regulation of insulin secretion;GO:0051001|negative regulation of nitric-oxide synthase activity;GO:0051966|regulation of synaptic transmission, glutamatergic;GO:0060135|maternal process involved in female pregnancy;GO:0060259|regulation of feeding behavior;GO:0060405|regulation of penile erection;GO:0098921|retrograde trans-synaptic signaling by endocannabinoid;GO:0099553|trans-synaptic signaling by endocannabinoid, modulating synaptic transmission;GO:0099703|induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0005886|plasma membrane;GO:0015629|actin cytoskeleton;GO:0030424|axon;GO:0030426|growth cone;GO:0032592|integral component of mitochondrial membrane;GO:0042734|presynaptic membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0045121|membrane raft;GO:0098793|presynapse;GO:0098978|glutamatergic synapse;GO:0098982|GABA-ergic synapse;GO:0099056|integral component of presynaptic membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004949|cannabinoid receptor activity;GO:0005515|protein binding;GO:0042802|identical protein binding;GO:0099635|voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels;","K04277","CNR1; cannabinoid receptor 1"]
["ENSRNOG00000004317",289,23.99470489,168,10.80751362,2.220187339,1.150681416,{"v":4.24688e-17,"d":"4.25E-17"},{"v":1.37147e-16,"d":"1.37E-16"},"up","yes","Vipr2","protein_coding","chr6:137001511-137070597:+","gi|465417|sp|P35000.1|VIPR2_RAT",2314,0,"RecName: Full=Vasoactive intestinal polypeptide receptor 2; Short=VIP-R-2; AltName: Full=Pituitary adenylate cyclase-activating polypeptide type III receptor; Short=PACAP type III receptor; Short=PACAP-R-3; Short=PACAP-R3; Flags: Precursor","gi|8394531|ref|NM_017238.1|",3337,0,"Rattus norvegicus vasoactive intestinal peptide receptor 2 (Vipr2), mRNA","P35000",895,0,"Vasoactive intestinal polypeptide receptor 2",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0007166|cell surface receptor signaling pathway;GO:0007188|adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007190|activation of adenylate cyclase activity;GO:0048662|negative regulation of smooth muscle cell proliferation;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004999|vasoactive intestinal polypeptide receptor activity;GO:0008528|G protein-coupled peptide receptor activity;GO:0017046|peptide hormone binding;","K04590","VIPR2; vasoactive intestinal peptide receptor 2"]
["ENSRNOG00000042592",354,29.39143783,226,14.53867903,2.021603047,1.015499744,{"v":4.28074e-17,"d":"4.28E-17"},{"v":1.3817e-16,"d":"1.38E-16"},"up","yes","Rgs10","protein_coding","chr1:182946336-182987697:-","gi|564331113|ref|XP_006230387.1|",771,{"v":2E-99,"d":"2.00E-99"},"PREDICTED: regulator of G-protein signaling 10 isoform X1 [Rattus norvegicus]","gi|672038557|ref|XM_006230325.2|",882,0,"PREDICTED: Rattus norvegicus regulator of G-protein signaling 10 (Rgs10), transcript variant X1, mRNA","P49806",295,{"v":4e-98,"d":"4.00E-98"},"Regulator of G-protein signaling 10",".",".",".",".","pfam00615","RGS","Regulator of G protein signaling domain. RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.","GO:0001975|response to amphetamine;GO:0007213|G protein-coupled acetylcholine receptor signaling pathway;GO:0008277|regulation of G protein-coupled receptor signaling pathway;GO:0009968|negative regulation of signal transduction;GO:0043547|positive regulation of GTPase activity;","GO:0005634|nucleus;GO:0005829|cytosol;GO:0043025|neuronal cell body;GO:0043197|dendritic spine;GO:0043679|axon terminus;","GO:0001965|G-protein alpha-subunit binding;GO:0003674|molecular_function;GO:0005096|GTPase activator activity;","K16449","RGS; regulator of G-protein signaling"]
["ENSRNOG00000025998",166,13.78242565,68,4.374469797,3.150650545,1.655649746,{"v":4.52579e-17,"d":"4.53E-17"},{"v":1.46006e-16,"d":"1.46E-16"},"up","yes","Crybg1","protein_coding","chr20:47426183-47621392:-","gi|672086845|ref|XP_008771253.1|",9879,0,"PREDICTED: absent in melanoma 1 protein isoform X2 [Rattus norvegicus]","gi|755532767|ref|XM_006512498.2|",4506,0,"PREDICTED: Mus musculus absent in melanoma 1 (Aim1), transcript variant X1, mRNA","Q9Y4K1",2340,0,"Beta/gamma crystallin domain-containing protein 1",".",".",".",".","pfam00030","Crystall","Beta/Gamma crystallin. The alignment comprises two Greek key motifs since the similarity between them is very low.","GO:0008150|biological_process;","GO:0005575|cellular_component;","GO:0003674|molecular_function;GO:0030246|carbohydrate binding;",".","."]
["ENSRNOG00000047493",178,14.77874557,77,4.95344374,2.98352951,1.577020046,{"v":4.56895E-17,"d":"4.57E-17"},{"v":1.47324e-16,"d":"1.47E-16"},"up","yes","Slco1a4","protein_coding","chr4:174710004-175254573:-","gi|13540642|ref|NP_110465.1|",3313,0,"solute carrier organic anion transporter family member 1A5 [Rattus norvegicus]","gi|672051315|ref|XM_008763351.1|",2937,0,"PREDICTED: Rattus norvegicus solute carrier organic anion transporter family, member 1A2 (Slco1a2), transcript variant X1, mRNA","O88397",1280,0,"Solute carrier organic anion transporter family member 1A5",".",".",".",".","pfam03137","OATP","Organic Anion Transporter Polypeptide (OATP) family. This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.","GO:0006820|anion transport;GO:0010468|regulation of gene expression;GO:0015721|bile acid and bile salt transport;GO:0038183|bile acid signaling pathway;GO:0043252|sodium-independent organic anion transport;GO:0055085|transmembrane transport;GO:0071466|cellular response to xenobiotic stimulus;GO:0120188|regulation of bile acid secretion;GO:1904486|response to 17alpha-ethynylestradiol;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009925|basal plasma membrane;GO:0016020|membrane;","GO:0008514|organic anion transmembrane transporter activity;GO:0015125|bile acid transmembrane transporter activity;GO:0015347|sodium-independent organic anion transmembrane transporter activity;","K03460","SLCO1A; solute carrier organic anion transporter family, member 1A"]
["ENSRNOG00000015948",159,13.20123902,63,4.052817606,3.257299071,1.703676188,{"v":4.9553e-17,"d":"4.96E-17"},{"v":1.59621e-16,"d":"1.60E-16"},"up","yes","Slc1a5","protein_coding","chr1:77456694-77470952:+","gi|149056876|gb|EDM08307.1|",2365,0,"solute carrier family 1 (neutral amino acid transporter), member 5, isoform CRA_a [Rattus norvegicus]","gi|51592103|ref|NM_175758.3|",1536,0,"Rattus norvegicus solute carrier family 1 member 5 (Slc1a5), mRNA","P51912",741,0,"Neutral amino acid transporter B(0)","aq_1330",170,{"v":1e-44,"d":"1.00E-44"},"COG1301","pfam00375","SDF","Sodium:dicarboxylate symporter family.","GO:0006868|glutamine transport;GO:0010585|glutamine secretion;GO:0015825|L-serine transport;GO:0070207|protein homotrimerization;GO:0140009|L-aspartate import across plasma membrane;GO:1903803|L-glutamine import across plasma membrane;","GO:0005886|plasma membrane;GO:0009925|basal plasma membrane;GO:0016021|integral component of membrane;","GO:0015175|neutral amino acid transmembrane transporter activity;GO:0015183|L-aspartate transmembrane transporter activity;GO:0015186|L-glutamine transmembrane transporter activity;GO:0015194|L-serine transmembrane transporter activity;GO:0015293|symporter activity;","K05616","SLC1A5; solute carrier family 1 (neutral amino acid transporter), member 5"]
["ENSRNOG00000062002",95,7.88753275,21,1.350939202,5.838554939,2.545611342,{"v":5.64468e-17,"d":"5.64E-17"},{"v":1.81461e-16,"d":"1.81E-16"},"up","yes","Kcna3","protein_coding","chr2:194632196-194650138:+","gi|795363234|ref|XP_011933735.1|",2221,0,"PREDICTED: potassium voltage-gated channel subfamily A member 3 [Cercocebus atys]","gi|880918565|ref|XM_005076595.2|",3873,0,"PREDICTED: Mesocricetus auratus potassium channel, voltage gated shaker related subfamily A, member 3 (Kcna3), mRNA","P22001",853,0,"Potassium voltage-gated channel subfamily A member 3","DR0830",77,{"v":8E-14,"d":"8.00E-14"},"COG1226","pfam02214","BTB_2","BTB/POZ domain. In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.","GO:0006813|potassium ion transport;GO:0034765|regulation of ion transmembrane transport;GO:0051260|protein homooligomerization;GO:0071805|potassium ion transmembrane transport;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0008076|voltage-gated potassium channel complex;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0044305|calyx of Held;GO:0045121|membrane raft;GO:0098978|glutamatergic synapse;GO:0099055|integral component of postsynaptic membrane;GO:0099056|integral component of presynaptic membrane;","GO:0005249|voltage-gated potassium channel activity;GO:0005251|delayed rectifier potassium channel activity;GO:0005515|protein binding;GO:0015271|outward rectifier potassium channel activity;","K04876","KCNA3, KV1.3; potassium voltage-gated channel Shaker-related subfamily A member 3"]
["ENSRNOG00000038286",65,5.396732934,6,0.385982629,13.98180262,3.805478468,{"v":8.62051e-17,"d":"8.62E-17"},{"v":2.75878e-16,"d":"2.76E-16"},"up","yes","Slamf6","protein_coding","chr13:84383742-84405300:+","gi|300794200|ref|NP_001178861.1|",1761,0,"SLAM family member 6 [Rattus norvegicus]","gi|300794199|ref|NM_001191932.1|",1635,0,"Rattus norvegicus SLAM family member 6 (Slamf6), mRNA","Q9ET39",441,{"v":5e-149,"d":"5.00E-149"},"SLAM family member 6",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0001779|natural killer cell differentiation;GO:0001787|natural killer cell proliferation;GO:0032729|positive regulation of interferon-gamma production;GO:0032740|positive regulation of interleukin-17 production;GO:0042110|T cell activation;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;GO:0072540|T-helper 17 cell lineage commitment;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;",".","K16852","SLAMF6, CD352; SLAM family member 6"]
["ENSRNOG00000049919",59,4.898572971,0,0.032165219,152.2940962,7.250716206,{"v":9.10628e-17,"d":"9.11E-17"},{"v":2.90551e-16,"d":"2.91E-16"},"up","yes","ENSRNOG00000049919","protein_coding","chr15:29986103-29988926:-","gi|157820605|ref|NP_001103116.1|",1137,{"v":4e-155,"d":"4.00E-155"},"uncharacterized protein LOC691670 precursor [Rattus norvegicus]","gi|157820604|ref|NM_001109646.1|",748,0,"Rattus norvegicus similar to natural killer cell protease 7 (LOC691670), mRNA","P13366",302,{"v":1e-101,"d":"1.00E-101"},"Granzyme G","VC1200",83.6,{"v":1e-17,"d":"1.00E-17"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;","GO:0005737|cytoplasm;GO:0043231|intracellular membrane-bounded organelle;","GO:0004252|serine-type endopeptidase activity;",".","."]
["ENSRNOG00000003709",56,4.649492989,1,0.064330438,72.2751643,6.175428078,{"v":9.28785e-17,"d":"9.29E-17"},{"v":2.96197e-16,"d":"2.96E-16"},"up","yes","Kmo","protein_coding","chr13:87557286-87588881:+","gi|11024672|ref|NP_067604.1|",2525,0,"kynurenine 3-monooxygenase [Rattus norvegicus]","gi|298915137|emb|FQ210049.1|",3386,0,"Rattus norvegicus TL0ABA35YJ18 mRNA sequence","O88867",976,0,"Kynurenine 3-monooxygenase","YBL098w",274,{"v":4e-80,"d":"4.00E-80"},"COG0654","pfam01494","FAD_binding_3","FAD binding domain. This domain is involved in FAD binding in a number of enzymes.","GO:0006569|tryptophan catabolic process;GO:0007568|aging;GO:0009651|response to salt stress;GO:0014049|positive regulation of glutamate secretion;GO:0019674|NAD metabolic process;GO:0019805|quinolinate biosynthetic process;GO:0032496|response to lipopolysaccharide;GO:0034276|kynurenic acid biosynthetic process;GO:0034354|'de novo' NAD biosynthetic process from tryptophan;GO:0043420|anthranilate metabolic process;GO:0070189|kynurenine metabolic process;GO:0071222|cellular response to lipopolysaccharide;GO:0071347|cellular response to interleukin-1;GO:0097052|L-kynurenine metabolic process;GO:1901216|positive regulation of neuron death;GO:1903296|positive regulation of glutamate secretion, neurotransmission;","GO:0005615|extracellular space;GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0016021|integral component of membrane;","GO:0004502|kynurenine 3-monooxygenase activity;GO:0016174|NAD(P)H oxidase activity;GO:0050660|flavin adenine dinucleotide binding;GO:0071949|FAD binding;","K00486","KMO; kynurenine 3-monooxygenase [EC:1.14.13.9]"]
["ENSRNOG00000008134",184,15.27690554,83,5.339426369,2.861151083,1.516595681,{"v":1.06822E-16,"d":"1.07E-16"},{"v":3.39987e-16,"d":"3.40E-16"},"up","yes","Mefv","protein_coding","chr10:11787422-11796973:+","gi|149042690|gb|EDL96327.1|",4296,0,"Mediterranean fever, isoform CRA_b [Rattus norvegicus]","gi|13928875|ref|NM_031634.1|",2012,0,"Rattus norvegicus Mediterranean fever (Mefv), mRNA","Q9JJ25",1290,0,"Pyrin",".",".",".",".","pfam02758","PYRIN","PAAD/DAPIN/Pyrin domain. This domain is predicted to contain 6 alpha helices and to have the same fold as the pfam00531 domain. This similarity may mean that this is a protein-protein interaction domain.","GO:0006954|inflammatory response;GO:0010468|regulation of gene expression;GO:0010508|positive regulation of autophagy;GO:0016567|protein ubiquitination;GO:0032496|response to lipopolysaccharide;GO:0032651|regulation of interleukin-1 beta production;GO:0032691|negative regulation of interleukin-1 beta production;GO:0032695|negative regulation of interleukin-12 production;GO:0034021|response to silicon dioxide;GO:0034341|response to interferon-gamma;GO:0045087|innate immune response;GO:0050728|negative regulation of inflammatory response;GO:0071641|negative regulation of macrophage inflammatory protein 1 alpha production;GO:1900016|negative regulation of cytokine production involved in inflammatory response;GO:1900226|negative regulation of NLRP3 inflammasome complex assembly;GO:1904270|pyroptosome complex assembly;GO:2001056|positive regulation of cysteine-type endopeptidase activity;","GO:0001726|ruffle;GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005776|autophagosome;GO:0005829|cytosol;GO:0005874|microtubule;GO:0005875|microtubule associated complex;GO:0030027|lamellipodium;GO:0031410|cytoplasmic vesicle;","GO:0003674|molecular_function;GO:0003779|actin binding;GO:0008270|zinc ion binding;GO:0042802|identical protein binding;GO:0061630|ubiquitin protein ligase activity;","K12803","MEFV; pyrin"]
["ENSRNOG00000031540",203,16.85441209,98,6.304382942,2.673443577,1.418699229,{"v":1.11605e-16,"d":"1.12E-16"},{"v":3.5468e-16,"d":"3.55E-16"},"up","yes","ENSRNOG00000031540","protein_coding","chr13:83117297-83118233:+","gi|84000579|ref|NP_071945.3|",602,{"v":2e-74,"d":"2.00E-74"},"ferritin light chain 1 [Rattus norvegicus]","gi|228480381|gb|AC111734.5|",588,0,"Rattus norvegicus CH230-184H10 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P02793",236,{"v":6e-76,"d":"6.00E-76"},"Ferritin light chain 1",".",".",".",".","pfam00210","Ferritin","Ferritin-like domain. This family contains ferritins and other ferritin-like proteins such as members of the DPS family and bacterioferritins.","GO:0006826|iron ion transport;GO:0006880|intracellular sequestering of iron ion;","GO:0005737|cytoplasm;","GO:0008198|ferrous iron binding;GO:0008199|ferric iron binding;",".","."]
["ENSRNOG00000019477",160,13.28426568,65,4.181478482,3.176930299,1.667633438,{"v":1.15478E-16,"d":"1.15E-16"},{"v":3.66622e-16,"d":"3.67E-16"},"up","yes","Zmynd15","protein_coding","chr10:55171198-55177812:+","gi|157786632|ref|NP_001099270.1|",3202,0,"zinc finger MYND domain-containing protein 15 [Rattus norvegicus]","gi|157786631|ref|NM_001105800.1|",2879,0,"Rattus norvegicus zinc finger, MYND-type containing 15 (Zmynd15), mRNA","Q8C0R7",1193,0,"Zinc finger MYND domain-containing protein 15",".",".",".",".","pfam01753","zf-MYND","MYND finger.","GO:0007286|spermatid development;GO:0045892|negative regulation of transcription, DNA-templated;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0042826|histone deacetylase binding;","K24081","ZMYND15; zinc finger MYND domain-containing protein 15"]
["ENSRNOG00000051906",60,4.981599631,4,0.257321753,19.35941901,4.274963752,{"v":1.22632e-16,"d":"1.23E-16"},{"v":3.88755e-16,"d":"3.89E-16"},"up","yes","AABR07035561.2","protein_coding","chr12:17364080-17365280:+","gi|149028544|gb|EDL83916.1|",924,{"v":9e-124,"d":"9.00E-124"},"rCG55971, partial [Rattus norvegicus]","gi|672026601|ref|XM_006221297.2|",628,0,"PREDICTED: Rattus norvegicus similar to paired immunoglobin-like type 2 receptor beta (LOC680923), transcript variant X3, mRNA","Q6DKI7",171,{"v":1e-49,"d":"1.00E-49"},"Transmembrane protein PVRIG",".",".",".",".","pfam00387","PI-PLC-Y","Phosphatidylinositol-specific phospholipase C, Y domain. This associates with pfam00388 to form a single structural unit.",".",".",".",".","."]
["ENSRNOG00000014448",324,26.90063801,202,12.99474851,2.070116092,1.049711676,{"v":1.42444E-16,"d":"1.42E-16"},{"v":4.50446e-16,"d":"4.50E-16"},"up","yes","Arntl","protein_coding","chr1:167331633-167430231:+","gi|817283650|ref|XP_012312038.1|",3111,0,"PREDICTED: aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X3 [Aotus nancymaae]","gi|672037826|ref|XM_008759716.1|",2245,0,"PREDICTED: Rattus norvegicus aryl hydrocarbon receptor nuclear translocator-like (Arntl), transcript variant X2, mRNA","Q9EPW1",1177,0,"Aryl hydrocarbon receptor nuclear translocator-like protein 1",".",".",".",".","pfam14598","PAS_11","PAS domain. This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).","GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006606|protein import into nucleus;GO:0007283|spermatogenesis;GO:0007623|circadian rhythm;GO:0032007|negative regulation of TOR signaling;GO:0032922|circadian regulation of gene expression;GO:0042176|regulation of protein catabolic process;GO:0042634|regulation of hair cycle;GO:0042753|positive regulation of circadian rhythm;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045599|negative regulation of fat cell differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050767|regulation of neurogenesis;GO:0050796|regulation of insulin secretion;GO:0051726|regulation of cell cycle;GO:0051775|response to redox state;GO:0060137|maternal process involved in parturition;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:0090403|oxidative stress-induced premature senescence;GO:0120163|negative regulation of cold-induced thermogenesis;GO:1901985|positive regulation of protein acetylation;GO:2000074|regulation of type B pancreatic cell development;GO:2000323|negative regulation of glucocorticoid receptor signaling pathway;GO:2000772|regulation of cellular senescence;GO:2001016|positive regulation of skeletal muscle cell differentiation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005737|cytoplasm;GO:0016604|nuclear body;GO:0016605|PML body;GO:0033391|chromatoid body;GO:0034751|aryl hydrocarbon receptor complex;GO:0043231|intracellular membrane-bounded organelle;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0017162|aryl hydrocarbon receptor binding;GO:0043425|bHLH transcription factor binding;GO:0043565|sequence-specific DNA binding;GO:0046982|protein heterodimerization activity;GO:0046983|protein dimerization activity;GO:0051879|Hsp90 protein binding;GO:0070888|E-box binding;GO:1990837|sequence-specific double-stranded DNA binding;","K02296","ARNTL, BMAL1, CYC; aryl hydrocarbon receptor nuclear translocator-like protein 1"]
["ENSRNOG00000037331",116,9.631092621,35,2.251565336,4.277509724,2.096771134,{"v":1.76948e-16,"d":"1.77E-16"},{"v":5.57076E-16,"d":"5.57E-16"},"up","yes","Cd33","protein_coding","chr1:93930971-93950149:-","gi|149056119|gb|EDM07550.1|",1392,0,"rCG54544 [Rattus norvegicus]","gi|672036639|ref|XM_008759423.1|",1186,0,"PREDICTED: Rattus norvegicus CD33 molecule (Cd33), mRNA","Q63994",429,{"v":2e-144,"d":"2.00E-144"},"Myeloid cell surface antigen CD33",".",".",".",".","pfam10471","APC_CDC26","Anaphase-promoting complex APC subunit 1. The anaphase-promoting complex (APC) or cyclosome is a cell cycle-regulated ubiquitin-protein ligase that regulates important events in mitosis such as the initiation of anaphase and exit from telophase. The APC, in conjunction with other enzymes, assembles multi-ubiquitin chains on a variety of regulatory proteins thereby targeting them for proteolysis by the 26S proteasome. CDC26 is one of the nine or so subunits identified within APC but its exact function is not known. The APC/C becomes active at the metaphase/anaphase transition and remains active during G1 phase. One mechanism linked to activation of the APC/C is phosphorylation. The yeast APC/C is composed of at least 13 subunits, but the function of many of the subunits is unknown. Hcn1 is the smallest subunit of the S. pombe APC/C, and is found to be essential for cell viability, APC/C integrity, and proper APC/C regulation. In addition, Hcn1 phosphorylation indicates a specific role for the phosphorylation of this subunit late in the cell cycle.","GO:0002765|immune response-inhibiting signal transduction;GO:0007155|cell adhesion;GO:0032691|negative regulation of interleukin-1 beta production;GO:0032717|negative regulation of interleukin-8 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0050714|positive regulation of protein secretion;GO:0051926|negative regulation of calcium ion transport;GO:0098609|cell-cell adhesion;GO:1903615|positive regulation of protein tyrosine phosphatase activity;","GO:0005654|nucleoplasm;GO:0005777|peroxisome;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0019903|protein phosphatase binding;GO:0033691|sialic acid binding;","K06473","CD33, SIGLEC3; CD33 antigen"]
["ENSRNOG00000065970",70,5.811866237,9,0.578973944,10.03821726,3.327431172,{"v":2.32831E-16,"d":"2.33E-16"},{"v":7.29778e-16,"d":"7.30E-16"},"up","yes","Klrc3","protein_coding","chr4:163106024-163112336:-","gi|71361671|ref|NP_001025079.1|",1234,{"v":6e-166,"d":"6.00E-166"},"killer cell lectin-like receptor subfamily C, member 3 [Rattus norvegicus]","gi|672051215|ref|XR_592292.1|",1518,0,"PREDICTED: Rattus norvegicus killer cell lectin-like receptor subfamily C, member 3 (Klrc3), transcript variant X1, misc_RNA","Q9MZJ3",166,{"v":4e-46,"d":"4.00E-46"},"NKG2-A/NKG2-B type II integral membrane protein",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type",".",".",".",".","."]
["ENSRNOG00000010522",129,10.71043921,44,2.83053928,3.783886443,1.919868793,{"v":2.38808e-16,"d":"2.39E-16"},{"v":7.47777e-16,"d":"7.48E-16"},"up","yes","Tlr4","protein_coding","chr5:80145826-80159628:+","gi|149059567|gb|EDM10505.1|",4145,0,"toll-like receptor 4 [Rattus norvegicus]","gi|240147721|gb|GQ175880.1|",3327,0,"Rattus norvegicus toll-like receptor 4 (Tlr4) mRNA, complete cds","Q9QX05",1595,0,"Toll-like receptor 4",".",".",".",".","pfam01582","TIR","TIR domain. The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.","GO:0001666|response to hypoxia;GO:0001774|microglial cell activation;GO:0002218|activation of innate immune response;GO:0002224|toll-like receptor signaling pathway;GO:0002246|wound healing involved in inflammatory response;GO:0002322|B cell proliferation involved in immune response;GO:0002537|nitric oxide production involved in inflammatory response;GO:0002730|regulation of dendritic cell cytokine production;GO:0002755|MyD88-dependent toll-like receptor signaling pathway;GO:0002758|innate immune response-activating signal transduction;GO:0003009|skeletal muscle contraction;GO:0006691|leukotriene metabolic process;GO:0006909|phagocytosis;GO:0006954|inflammatory response;GO:0006979|response to oxidative stress;GO:0007252|I-kappaB phosphorylation;GO:0009617|response to bacterium;GO:0009636|response to toxic substance;GO:0010572|positive regulation of platelet activation;GO:0010628|positive regulation of gene expression;GO:0014002|astrocyte development;GO:0014823|response to activity;GO:0014911|positive regulation of smooth muscle cell migration;GO:0016064|immunoglobulin mediated immune response;GO:0030890|positive regulation of B cell proliferation;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0032496|response to lipopolysaccharide;GO:0032497|detection of lipopolysaccharide;GO:0032526|response to retinoic acid;GO:0032570|response to progesterone;GO:0032680|regulation of tumor necrosis factor production;GO:0032689|negative regulation of interferon-gamma production;GO:0032700|negative regulation of interleukin-17 production;GO:0032707|negative regulation of interleukin-23 production;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032722|positive regulation of chemokine production;GO:0032727|positive regulation of interferon-alpha production;GO:0032728|positive regulation of interferon-beta production;GO:0032729|positive regulation of interferon-gamma production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032732|positive regulation of interleukin-1 production;GO:0032733|positive regulation of interleukin-10 production;GO:0032735|positive regulation of interleukin-12 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032868|response to insulin;GO:0032874|positive regulation of stress-activated MAPK cascade;GO:0034142|toll-like receptor 4 signaling pathway;GO:0035666|TRIF-dependent toll-like receptor signaling pathway;GO:0036120|cellular response to platelet-derived growth factor stimulus;GO:0042116|macrophage activation;GO:0042742|defense response to bacterium;GO:0043032|positive regulation of macrophage activation;GO:0043065|positive regulation of apoptotic process;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043278|response to morphine;GO:0043388|positive regulation of DNA binding;GO:0043406|positive regulation of MAP kinase activity;GO:0045348|positive regulation of MHC class II biosynthetic process;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0045471|response to ethanol;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046330|positive regulation of JNK cascade;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0050671|positive regulation of lymphocyte proliferation;GO:0050727|regulation of inflammatory response;GO:0050729|positive regulation of inflammatory response;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050829|defense response to Gram-negative bacterium;GO:0050965|detection of temperature stimulus involved in sensory perception of pain;GO:0050966|detection of mechanical stimulus involved in sensory perception of pain;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051384|response to glucocorticoid;GO:0051770|positive regulation of nitric-oxide synthase biosynthetic process;GO:0051930|regulation of sensory perception of pain;GO:0060729|intestinal epithelial structure maintenance;GO:0060907|positive regulation of macrophage cytokine production;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070430|positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway;GO:0070434|positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0070542|response to fatty acid;GO:0071222|cellular response to lipopolysaccharide;GO:0071223|cellular response to lipoteichoic acid;GO:0071260|cellular response to mechanical stimulus;GO:0071300|cellular response to retinoic acid;GO:0071346|cellular response to interferon-gamma;GO:0120163|negative regulation of cold-induced thermogenesis;GO:0140052|cellular response to oxidised low-density lipoprotein particle stimulus;GO:1900017|positive regulation of cytokine production involved in inflammatory response;GO:1900227|positive regulation of NLRP3 inflammasome complex assembly;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1903223|positive regulation of oxidative stress-induced neuron death;GO:1903428|positive regulation of reactive oxygen species biosynthetic process;GO:1903974|positive regulation of cellular response to macrophage colony-stimulating factor stimulus;GO:1904466|positive regulation of matrix metallopeptidase secretion;GO:1904646|cellular response to amyloid-beta;GO:1990268|response to gold nanoparticle;GO:2000343|positive regulation of chemokine (C-X-C motif) ligand 2 production;","GO:0001726|ruffle;GO:0001891|phagocytic cup;GO:0005737|cytoplasm;GO:0005769|early endosome;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0031226|intrinsic component of plasma membrane;GO:0043235|receptor complex;GO:0045121|membrane raft;GO:0046696|lipopolysaccharide receptor complex;GO:0048471|perinuclear region of cytoplasm;","GO:0001530|lipopolysaccharide binding;GO:0001875|lipopolysaccharide receptor activity;GO:0003953|NAD+ nucleosidase activity;GO:0004888|transmembrane signaling receptor activity;GO:0005102|signaling receptor binding;GO:0005515|protein binding;GO:0038023|signaling receptor activity;GO:0042802|identical protein binding;GO:0043548|phosphatidylinositol 3-kinase binding;GO:0046982|protein heterodimerization activity;GO:0050135|NAD(P)+ nucleosidase activity;GO:0061809|NAD+ nucleotidase, cyclic ADP-ribose generating;","K10160","TLR4, CD284; toll-like receptor 4"]
["ENSRNOG00000016012",202,16.77138543,99,6.36871338,2.633402451,1.396928019,{"v":2.95514e-16,"d":"2.96E-16"},{"v":9.21729e-16,"d":"9.22E-16"},"up","yes","Spats2l","protein_coding","chr9:59320276-59493967:+","gi|148667641|gb|EDL00058.1|",3023,0,"RIKEN cDNA 2810022L02, isoform CRA_c, partial [Mus musculus]","gi|672065181|ref|XM_006244992.2|",2336,0,"PREDICTED: Rattus norvegicus spermatogenesis associated, serine-rich 2-like (Spats2l), transcript variant X3, mRNA","Q5U2T3",1115,0,"SPATS2-like protein",".",".",".",".","pfam07139","DUF1387","Protein of unknown function (DUF1387). This family represents a conserved region approximately 300 residues long within a number of hypothetical proteins of unknown function that seem to be restricted to mammals.",".","GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0032991|protein-containing complex;",".",".","."]
["ENSRNOG00000062245",251,20.83969179,140,9.006261346,2.31391151,1.210333693,{"v":3.48798e-16,"d":"3.49E-16"},{"v":1.0837E-15,"d":"1.08E-15"},"up","yes","Ndufa10l1","protein_coding","chr6:59879312-59881241:-","gi|32996721|ref|NP_872612.1|",1839,0,"NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like [Rattus norvegicus]","gi|30171808|gb|AY260163.1|",1872,0,"Rattus norvegicus NADH dehydrogenase 1 alpha subcomplex 10-like protein mRNA, complete cds","Q561S0",704,0,"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial","BS_yaaG",60.8,1e-09,"COG1428","pfam01712","dNK","Deoxynucleoside kinase. This family consists of various deoxynucleoside kinases cytidine EC:2.7.1.74, guanosine EC:2.7.1.113, adenosine EC:2.7.1.76 and thymidine kinase EC:2.7.1.21 (which also phosphorylates deoxyuridine and deoxycytosine.) These enzymes catalyse the production of deoxynucleotide 5'-monophosphate from a deoxynucleoside. Using ATP and yielding ADP in the process.","GO:0006120|mitochondrial electron transport, NADH to ubiquinone;GO:0032981|mitochondrial respiratory chain complex I assembly;","GO:0005737|cytoplasm;GO:0005747|mitochondrial respiratory chain complex I;GO:0005759|mitochondrial matrix;",".","K03954","NDUFA10; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 10"]
["ENSRNOG00000014357",220,18.26586532,114,7.333669953,2.490685487,1.316542856,{"v":3.53661e-16,"d":"3.54E-16"},{"v":1.09827E-15,"d":"1.10E-15"},"up","yes","Gja4","protein_coding","chr5:139633287-139635925:-","gi|11067369|ref|NP_067686.1|",1627,0,"gap junction alpha-4 protein [Rattus norvegicus]","gi|51036648|ref|NM_021654.2|",1590,0,"Rattus norvegicus gap junction protein, alpha 4 (Gja4), mRNA","Q03190",631,0,"Gap junction alpha-4 protein",".",".",".",".","pfam00029","Connexin","Connexin.","GO:0001568|blood vessel development;GO:0003158|endothelium development;GO:0006816|calcium ion transport;GO:0007154|cell communication;GO:0007267|cell-cell signaling;GO:0048265|response to pain;GO:0055085|transmembrane transport;","GO:0005921|gap junction;GO:0005922|connexin complex;GO:0016021|integral component of membrane;","GO:0005243|gap junction channel activity;","K07613","GJA4, CX37; gap junction alpha-4 protein"]
["ENSRNOG00000046663",239,19.84337187,130,8.362956964,2.372769817,1.246572151,{"v":3.80052e-16,"d":"3.80E-16"},{"v":1.17737E-15,"d":"1.18E-15"},"up","yes","Fcgr2a","protein_coding","chr13:83280790-83484920:-","gi|672074912|ref|XP_008767999.1|",1263,{"v":4e-164,"d":"4.00E-164"},"PREDICTED: low affinity immunoglobulin gamma Fc region receptor III-like isoform X2 [Rattus norvegicus]","gi|298894770|emb|FQ230932.1|",1294,0,"Rattus norvegicus TL0AEA7YO18 mRNA sequence","P27645",482,{"v":3E-162,"d":"3.00E-162"},"Low affinity immunoglobulin gamma Fc region receptor III",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0001788|antibody-dependent cellular cytotoxicity;GO:0001798|positive regulation of type IIa hypersensitivity;GO:0001805|positive regulation of type III hypersensitivity;GO:0001812|positive regulation of type I hypersensitivity;GO:0001813|regulation of antibody-dependent cellular cytotoxicity;GO:0001820|serotonin secretion;GO:0006910|phagocytosis, recognition;GO:0006911|phagocytosis, engulfment;GO:0007166|cell surface receptor signaling pathway;GO:0021675|nerve development;GO:0030593|neutrophil chemotaxis;GO:0032680|regulation of tumor necrosis factor production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0038094|Fc-gamma receptor signaling pathway;GO:0042590|antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:0045576|mast cell activation;GO:0050766|positive regulation of phagocytosis;GO:0050776|regulation of immune response;GO:1905449|regulation of Fc-gamma receptor signaling pathway involved in phagocytosis;","GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0004888|transmembrane signaling receptor activity;GO:0019770|IgG receptor activity;GO:0019864|IgG binding;GO:0034987|immunoglobulin receptor binding;","K06463","FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor IIIK06463; K06472"]
["ENSRNOG00000015994",67,5.562786255,8,0.514643505,10.80900895,3.434162347,{"v":4.23082E-16,"d":"4.23E-16"},{"v":1.30624e-15,"d":"1.31E-15"},"up","yes","Cd3d","protein_coding","chr8:45288749-45301809:+","gi|7709998|ref|NP_037301.1|",844,{"v":1E-108,"d":"1.00E-108"},"T-cell surface glycoprotein CD3 delta chain precursor [Rattus norvegicus]","gi|7709997|ref|NM_013169.1|",576,0,"Rattus norvegicus CD3d molecule (Cd3d), mRNA","P19377",329,{"v":4e-110,"d":"4.00E-110"},"T-cell surface glycoprotein CD3 delta chain",".",".",".",".","pfam02189","ITAM","Immunoreceptor tyrosine-based activation motif.","GO:0002250|adaptive immune response;GO:0007166|cell surface receptor signaling pathway;GO:0008150|biological_process;GO:0045059|positive thymic T cell selection;","GO:0005575|cellular_component;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0042101|T cell receptor complex;GO:0042105|alpha-beta T cell receptor complex;","GO:0003674|molecular_function;GO:0004888|transmembrane signaling receptor activity;GO:0042802|identical protein binding;","K06450","CD3D; T-cell surface glycoprotein CD3 delta chain"]
["ENSRNOG00000046196",69,5.728839576,9,0.578973944,9.89481416,3.306672612,{"v":4.53363e-16,"d":"4.53E-16"},{"v":1.39838e-15,"d":"1.40E-15"},"up","yes","Icos","protein_coding","chr9:62383832-62405672:+","gi|12018286|ref|NP_072132.1|",1065,{"v":2e-138,"d":"2.00E-138"},"inducible T-cell costimulator precursor [Rattus norvegicus]","gi|672065263|ref|XM_006245038.2|",2036,0,"PREDICTED: Rattus norvegicus inducible T-cell co-stimulator (Icos), transcript variant X3, mRNA","Q9R1T7",414,{"v":7e-140,"d":"7.00E-140"},"Inducible T-cell costimulator",".",".",".",".","pfam02961","BAF","Barrier to autointegration factor. The BAF protein has a SAM-domain-like bundle of orthogonally packed alpha-hairpins - one classic and one pseudo helix-hairpin-helix motif. The protein is involved in the prevention of retroviral DNA integration.","GO:0002517|T cell tolerance induction;GO:0031295|T cell costimulation;GO:0098609|cell-cell adhesion;","GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;","K06713","ICOS, AILIM, CD278; inducible T-cell co-stimulator"]
["ENSRNOG00000015774",100,8.302666052,26,1.672591393,4.963953592,2.311489628,{"v":4.55352e-16,"d":"4.55E-16"},{"v":1.40384E-15,"d":"1.40E-15"},"up","yes","Mreg","protein_coding","chr9:73787267-73842087:-","gi|564369136|ref|XP_006245327.1|",963,{"v":2e-122,"d":"2.00E-122"},"PREDICTED: melanoregulin isoform X1 [Rattus norvegicus]","gi|672065807|ref|XM_006245265.2|",1943,0,"PREDICTED: Rattus norvegicus melanoregulin (Mreg), transcript variant X1, mRNA","Q6NVG5",337,{"v":3e-109,"d":"3.00E-109"},"Melanoregulin",".",".",".",".","pfam05110","AF-4","AF-4 proto-oncoprotein. This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.","GO:0030318|melanocyte differentiation;GO:0032400|melanosome localization;GO:0032402|melanosome transport;GO:0043473|pigmentation;GO:0048066|developmental pigmentation;GO:0072385|minus-end-directed organelle transport along microtubule;GO:0090382|phagosome maturation;","GO:0030659|cytoplasmic vesicle membrane;GO:0031300|intrinsic component of organelle membrane;GO:0031902|late endosome membrane;GO:0032991|protein-containing complex;GO:0033162|melanosome membrane;GO:0042470|melanosome;","GO:0035091|phosphatidylinositol binding;",".","."]
["ENSRNOG00000022884",120,9.963199263,39,2.508887089,3.971162874,1.989561533,{"v":5.5745e-16,"d":"5.57E-16"},{"v":1.71118e-15,"d":"1.71E-15"},"up","yes","Cd84","protein_coding","chr13:84327553-84362076:+","gi|672074825|ref|XP_008767975.1|",1770,0,"PREDICTED: SLAM family member 5 isoform X1 [Rattus norvegicus]","gi|672074824|ref|XM_008769753.1|",1801,0,"PREDICTED: Rattus norvegicus CD84 molecule (Cd84), transcript variant X1, mRNA","Q18PI6",498,{"v":1e-170,"d":"1.00E-170"},"SLAM family member 5",".",".",".",".","pfam00078","RVT_1","Reverse transcriptase (RNA-dependent DNA polymerase). A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs, hepadnaviruses, and caulimoviruses.","GO:0031664|regulation of lipopolysaccharide-mediated signaling pathway;GO:0032685|negative regulation of granulocyte macrophage colony-stimulating factor production;GO:0032693|negative regulation of interleukin-10 production;GO:0032701|negative regulation of interleukin-18 production;GO:0032715|negative regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0033004|negative regulation of mast cell activation;GO:0042110|T cell activation;GO:0043030|regulation of macrophage activation;GO:0043305|negative regulation of mast cell degranulation;GO:0043410|positive regulation of MAPK cascade;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0071639|positive regulation of monocyte chemotactic protein-1 production;GO:2001256|regulation of store-operated calcium entry;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0042802|identical protein binding;","K06511","CD84; CD84 antigen"]
["ENSRNOG00000005565",89,7.389372787,20,1.286608764,5.743294306,2.521878492,{"v":7.55192e-16,"d":"7.55E-16"},{"v":2.29942e-15,"d":"2.30E-15"},"up","yes","Traf3ip3","protein_coding","chr13:104694805-104719673:-","gi|672075176|ref|XP_008768087.1|",2500,0,"PREDICTED: TRAF3-interacting JNK-activating modulator isoform X1 [Rattus norvegicus]","gi|672075175|ref|XM_008769865.1|",2465,0,"PREDICTED: Rattus norvegicus TRAF3 interacting protein 3 (Traf3ip3), transcript variant X1, mRNA","Q8C0G2",752,0,"TRAF3-interacting JNK-activating modulator",".",".",".",".","pfam07888","CALCOCO1","Calcium binding and coiled-coil domain (CALCOCO1) like. Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.",".",".",".",".","."]
["ENSRNOG00000002843",55,4.566466329,0,0.032165219,141.9690727,7.14943287,{"v":7.81427e-16,"d":"7.81E-16"},{"v":2.3759e-15,"d":"2.38E-15"},"up","yes","Cxcl6","protein_coding","chr14:17310426-17313093:-","gi|672075826|ref|XP_008768277.1|",517,{"v":2e-59,"d":"2.00E-59"},"PREDICTED: C-X-C motif chemokine 5 isoform X2 [Rattus norvegicus]","gi|672075825|ref|XM_008770055.1|",1378,0,"PREDICTED: Rattus norvegicus chemokine (C-X-C motif) ligand 6 (Cxcl6), transcript variant X3, mRNA","P97885",202,{"v":2e-60,"d":"2.00E-60"},"C-X-C motif chemokine 5",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0001776|leukocyte homeostasis;GO:0006952|defense response;GO:0006954|inflammatory response;GO:0007165|signal transduction;GO:0010332|response to gamma radiation;GO:0010976|positive regulation of neuron projection development;GO:0030593|neutrophil chemotaxis;GO:0030901|midbrain development;GO:0031100|animal organ regeneration;GO:0032496|response to lipopolysaccharide;GO:0032642|regulation of chemokine production;GO:0042119|neutrophil activation;GO:0046427|positive regulation of JAK-STAT cascade;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098|chemokine-mediated signaling pathway;GO:0070951|regulation of neutrophil mediated killing of gram-negative bacterium;GO:0071222|cellular response to lipopolysaccharide;","GO:0005615|extracellular space;","GO:0008009|chemokine activity;GO:0045236|CXCR chemokine receptor binding;","K05506","CXCL5_6, SCYB5_6; C-X-C motif chemokine 5/6"]
["ENSRNOG00000002964",57,4.73251965,4,0.257321753,18.39144806,4.20096317,{"v":9.47235e-16,"d":"9.47E-16"},{"v":2.86641E-15,"d":"2.87E-15"},"up","yes","Xcl1","protein_coding","chr13:77248717-77252329:-","gi|149058185|gb|EDM09342.1|",583,{"v":2e-74,"d":"2.00E-74"},"chemokine (C motif) ligand 1 [Rattus norvegicus]","gi|19705460|ref|NM_134361.1|",330,{"v":5e-171,"d":"5.00E-171"},"Rattus norvegicus chemokine (C motif) ligand 1 (Xcl1), mRNA","P51672",224,{"v":5E-74,"d":"5.00E-74"},"Lymphotactin",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0001916|positive regulation of T cell mediated cytotoxicity;GO:0002548|monocyte chemotaxis;GO:0002690|positive regulation of leukocyte chemotaxis;GO:0002725|negative regulation of T cell cytokine production;GO:0002726|positive regulation of T cell cytokine production;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007165|signal transduction;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007267|cell-cell signaling;GO:0009615|response to virus;GO:0010820|positive regulation of T cell chemotaxis;GO:0030593|neutrophil chemotaxis;GO:0031640|killing of cells of other organism;GO:0032689|negative regulation of interferon-gamma production;GO:0032703|negative regulation of interleukin-2 production;GO:0032733|positive regulation of interleukin-10 production;GO:0035782|mature natural killer cell chemotaxis;GO:0043433|negative regulation of DNA-binding transcription factor activity;GO:0043547|positive regulation of GTPase activity;GO:0045892|negative regulation of transcription, DNA-templated;GO:0048247|lymphocyte chemotaxis;GO:0050727|regulation of inflammatory response;GO:0051209|release of sequestered calcium ion into cytosol;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098|chemokine-mediated signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071353|cellular response to interleukin-4;GO:0071356|cellular response to tumor necrosis factor;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0071636|positive regulation of transforming growth factor beta production;GO:0071663|positive regulation of granzyme B production;GO:0090023|positive regulation of neutrophil chemotaxis;GO:2000412|positive regulation of thymocyte migration;GO:2000503|positive regulation of natural killer cell chemotaxis;GO:2000513|positive regulation of granzyme A production;GO:2000518|negative regulation of T-helper 1 cell activation;GO:2000538|positive regulation of B cell chemotaxis;GO:2000553|positive regulation of T-helper 2 cell cytokine production;GO:2000556|positive regulation of T-helper 1 cell cytokine production;GO:2000558|positive regulation of immunoglobulin production in mucosal tissue;GO:2000562|negative regulation of CD4-positive, alpha-beta T cell proliferation;GO:2000563|positive regulation of CD4-positive, alpha-beta T cell proliferation;GO:2000566|positive regulation of CD8-positive, alpha-beta T cell proliferation;","GO:0005615|extracellular space;","GO:0008009|chemokine activity;GO:0042379|chemokine receptor binding;GO:0042803|protein homodimerization activity;GO:0048020|CCR chemokine receptor binding;","K05507","XCL1, SCM1; C motif chemokine 1"]
["ENSRNOG00000052803",57,4.73251965,4,0.257321753,18.39144806,4.20096317,{"v":9.47235e-16,"d":"9.47E-16"},{"v":2.86641E-15,"d":"2.87E-15"},"up","yes","Klri1","protein_coding","chr4:163183669-163218870:-","gi|60593099|ref|NP_001012667.1|",1237,{"v":3e-168,"d":"3.00E-168"},"killer cell lectin-like receptor family I member 1 [Rattus norvegicus]","gi|298888087|emb|FQ233804.1|",1126,0,"Rattus norvegicus TL0AEA60YF14 mRNA sequence","Q5DT39",481,{"v":9E-170,"d":"9.00E-170"},"Killer cell lectin-like receptor subfamily I member 1",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type",".","GO:0005887|integral component of plasma membrane;","GO:0030246|carbohydrate binding;",".","."]
["ENSRNOG00000024569",170,14.11453229,76,4.889113302,2.886930905,1.529536579,{"v":1.01454e-15,"d":"1.01E-15"},{"v":3.06137e-15,"d":"3.06E-15"},"up","yes","Gimap9","protein_coding","chr4:77626138-77629497:+","gi|56676322|ref|NP_001008399.1|",1444,0,"GTPase, IMAP family member 9 [Rattus norvegicus]","gi|73909202|gb|BC103635.1|",1700,0,"Rattus norvegicus GTPase, IMAP family member 9, mRNA (cDNA clone MGC:124918 IMAGE:7100941), complete cds","Q8NHV1",306,{"v":6e-96,"d":"6.00E-96"},"GTPase IMAP family member 7",".",".",".",".","pfam04548","AIG1","AIG1 family. Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.",".","GO:0005829|cytosol;","GO:0005525|GTP binding;",".","."]
["ENSRNOG00000010045",69,5.728839576,10,0.643304382,8.905332744,3.154669518,{"v":1.7653e-15,"d":"1.77E-15"},{"v":5.26962e-15,"d":"5.27E-15"},"up","yes","Clec4a","protein_coding","chr4:156414688-156432402:+","gi|148235584|ref|NP_001005899.2|",1106,{"v":2e-148,"d":"2.00E-148"},"C-type lectin domain family 4 member A [Rattus norvegicus]","gi|281332176|ref|NM_001170333.1|",545,0,"Mus musculus C-type lectin domain family 4, member a2 (Clec4a2), transcript variant 1, mRNA","Q67EQ0",426,{"v":2e-148,"d":"2.00E-148"},"C-type lectin domain family 4 member A",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0001818|negative regulation of cytokine production;GO:0001819|positive regulation of cytokine production;GO:0001878|response to yeast;GO:0001879|detection of yeast;GO:0002223|stimulatory C-type lectin receptor signaling pathway;GO:0002250|adaptive immune response;GO:0002470|plasmacytoid dendritic cell antigen processing and presentation;GO:0032720|negative regulation of tumor necrosis factor production;GO:0036037|CD8-positive, alpha-beta T cell activation;GO:0042590|antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045087|innate immune response;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050832|defense response to fungus;GO:0061760|antifungal innate immune response;GO:1902533|positive regulation of intracellular signal transduction;GO:2000318|positive regulation of T-helper 17 type immune response;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0005509|calcium ion binding;GO:0005537|mannose binding;GO:0030246|carbohydrate binding;GO:0038187|pattern recognition receptor activity;","K10057","CLEC4A, CD367; C-type lectin domain family 4 member A"]
["ENSRNOG00000015590",128,10.62741255,46,2.959200157,3.591312512,1.8445112,{"v":1.84324E-15,"d":"1.84E-15"},{"v":5.49972e-15,"d":"5.50E-15"},"up","yes","Dnaaf1","protein_coding","chr19:47624181-47652313:+","gi|62079043|ref|NP_001014176.1|",2776,0,"dynein assembly factor 1, axonemal [Rattus norvegicus]","gi|62079042|ref|NM_001014154.1|",2011,0,"Rattus norvegicus dynein, axonemal, assembly factor 1 (Dnaaf1), mRNA","Q6AYH9",1073,0,"Dynein assembly factor 1, axonemal","SPAC4A8.12c",64.7,{"v":3E-10,"d":"3.00E-10"},"COG4886","pfam14580","LRR_9","Leucine-rich repeat.","GO:0001947|heart looping;GO:0003341|cilium movement;GO:0003356|regulation of cilium beat frequency;GO:0030324|lung development;GO:0035469|determination of pancreatic left/right asymmetry;GO:0036158|outer dynein arm assembly;GO:0036159|inner dynein arm assembly;GO:0044458|motile cilium assembly;GO:0060271|cilium assembly;GO:0060972|left/right pattern formation;GO:0070286|axonemal dynein complex assembly;GO:0071907|determination of digestive tract left/right asymmetry;GO:0071910|determination of liver left/right asymmetry;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005930|axoneme;GO:0016607|nuclear speck;","GO:0070840|dynein complex binding;","K19750","DNAAF1, LRRC50, ODA7; dynein axonemal assembly factor 1"]
["ENSRNOG00000061359",104,8.634772695,30,1.929913146,4.474176838,2.161622279,{"v":1.85832e-15,"d":"1.86E-15"},{"v":5.54212e-15,"d":"5.54E-15"},"up","yes","Psme1-ps1","protein_coding","chr17:50174186-50175160:+","gi|149032533|gb|EDL87411.1|",1128,{"v":2e-152,"d":"2.00E-152"},"rCG63136, partial [Rattus norvegicus]","gi|298906185|emb|FQ216423.1|",841,0,"Rattus norvegicus TL0ACA43YA18 mRNA sequence","Q63797",402,{"v":2e-139,"d":"2.00E-139"},"Proteasome activator complex subunit 1",".",".",".",".","pfam02252","PA28_beta","Proteasome activator pa28 beta subunit. PA28 activator complex (also known as 11s regulator of 20S proteasome) is a ring shaped hexameric structure of alternating alpha and beta subunits. This family represents the beta subunit. The activator complex binds to the 20S proteasome ana simulates peptidase activity in and ATP-independent manner.",".","GO:0008537|proteasome activator complex;",".",".","."]
["ENSRNOG00000022110",51,4.234359687,1,0.064330438,65.82202463,6.040498498,{"v":1.95802e-15,"d":"1.96E-15"},{"v":5.83128e-15,"d":"5.83E-15"},"up","yes","Gcsam","protein_coding","chr11:55196712-55206992:-","gi|293352180|ref|XP_001064866.2|",982,{"v":2e-123,"d":"2.00E-123"},"PREDICTED: germinal center-associated signaling and motility protein isoform X1 [Rattus norvegicus]","gi|672026024|ref|XM_003752512.3|",2825,0,"PREDICTED: Rattus norvegicus germinal center-associated, signaling and motility (Gcsam), transcript variant X1, mRNA","Q6RFH4",326,{"v":2e-103,"d":"2.00E-103"},"Germinal center-associated signaling and motility protein",".",".",".",".","pfam09695","YtfJ_HI0045","Bacterial protein of unknown function (YtfJ_HI0045). These are sequences from gamma proteobacteria that are related to the Escherichia coli protein, YtfJ.","GO:0050855|regulation of B cell receptor signaling pathway;GO:2000402|negative regulation of lymphocyte migration;",".","GO:0003779|actin binding;GO:0019901|protein kinase binding;GO:0045159|myosin II binding;",".","."]
["ENSRNOG00000023030",51,4.234359687,1,0.064330438,65.82202463,6.040498498,{"v":1.95802e-15,"d":"1.96E-15"},{"v":5.83128e-15,"d":"5.83E-15"},"up","yes","Cd96","protein_coding","chr11:54702290-54776621:+","gi|68163543|ref|NP_001020203.1|",3022,0,"T-cell surface protein tactile precursor [Rattus norvegicus]","gi|68163542|ref|NM_001025032.1|",2053,0,"Rattus norvegicus CD96 molecule (Cd96), mRNA","Q5BK49",1172,0,"T-cell surface protein tactile",".",".",".",".","pfam08205","C2-set_2","CD80-like C2-set immunoglobulin domain. These domains belong to the immunoglobulin superfamily.","GO:0002728|negative regulation of natural killer cell cytokine production;GO:0006954|inflammatory response;GO:0007160|cell-matrix adhesion;GO:0032496|response to lipopolysaccharide;GO:0032689|negative regulation of interferon-gamma production;","GO:0005737|cytoplasm;GO:0016021|integral component of membrane;",".","K06517","CD96; CD96 antigen"]
["ENSRNOG00000063314",195,16.1901988,97,6.240052504,2.594561311,1.375490628,{"v":2.04779e-15,"d":"2.05E-15"},{"v":6.09296e-15,"d":"6.09E-15"},"up","yes","Utp23","protein_coding","chr7:83189656-83196655:+","gi|187282097|ref|NP_001119738.1|",1163,{"v":1e-149,"d":"1.00E-149"},"rRNA-processing protein UTP23 homolog [Rattus norvegicus]","gi|187282096|ref|NM_001126266.1|",985,0,"Rattus norvegicus UTP23, small subunit processome component (Utp23), mRNA","Q9CX11",424,{"v":4e-140,"d":"4.00E-140"},"rRNA-processing protein UTP23 homolog","SPCC18.12c",101,{"v":2e-22,"d":"2.00E-22"},"COG1412","pfam04900","Fcf1","Fcf1. Fcf1 is a nucleolar protein involved in pre-rRNA processing. Depletion of yeast Fcf1 and Fcf2 leads to a decrease in synthesis of the 18S rRNA and results in a deficit in 40S ribosomal subunits.",".",".",".",".","."]
["ENSRNOG00000052064",136,11.29162583,52,3.345182786,3.375488443,1.755096279,{"v":2.3629e-15,"d":"2.36E-15"},{"v":7.01095e-15,"d":"7.01E-15"},"up","yes","Parvg","protein_coding","chr7:115456209-115475104:+","gi|194474058|ref|NP_001124055.1|",1661,0,"gamma-parvin [Rattus norvegicus]","gi|194474057|ref|NM_001130583.1|",2536,0,"Rattus norvegicus parvin, gamma (Parvg), mRNA","Q9ERD8",592,0,"Gamma-parvin",".",".",".",".","pfam00307","CH","Calponin homology (CH) domain. The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.","GO:0007163|establishment or maintenance of cell polarity;GO:0030031|cell projection assembly;GO:0031532|actin cytoskeleton reorganization;GO:0034446|substrate adhesion-dependent cell spreading;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005925|focal adhesion;GO:0015629|actin cytoskeleton;","GO:0003779|actin binding;","K06275","PARV; parvin"]
["ENSRNOG00000016302",165,13.69939899,74,4.760452426,2.877751474,1.524942005,{"v":3.05305e-15,"d":"3.05E-15"},{"v":8.98366e-15,"d":"8.98E-15"},"up","yes","Cnnm1","protein_coding","chr1:242296422-242353513:+","gi|564333977|ref|XP_006231545.1|",4140,0,"PREDICTED: metal transporter CNNM1 isoform X1 [Rattus norvegicus]","gi|672040425|ref|XM_006231483.2|",3694,0,"PREDICTED: Rattus norvegicus cyclin M1 (Cnnm1), transcript variant X1, mRNA","Q0GA42",1526,0,"Metal transporter CNNM1","YOL060c_1",130,{"v":3e-31,"d":"3.00E-31"},"COG1253","pfam01595","DUF21","Domain of unknown function DUF21. This transmembrane region has no known function. Many of the sequences in this family are annotated as hemolysins, however this is due to a similarity to Treponema hyodysenteriae hemolysin C that does not contain this domain. This domain is found in the N-terminus of the proteins adjacent to two intracellular CBS domains pfam00571.","GO:0006810|transport;GO:0010960|magnesium ion homeostasis;GO:0055085|transmembrane transport;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0043025|neuronal cell body;GO:0043231|intracellular membrane-bounded organelle;","GO:0022857|transmembrane transporter activity;","K16302","CNNM; metal transporter CNNM"]
["ENSRNOG00000069054",50,4.151333026,1,0.064330438,64.5313967,6.011929346,{"v":3.62207e-15,"d":"3.62E-15"},{"v":1.06384E-14,"d":"1.06E-14"},"up","yes","ENSRNOG00000069054","lncRNA","chr17:31512272-31540904:-","gi|149032948|gb|EDL87789.1|",190,{"v":6e-15,"d":"6.00E-15"},"rCG19984, partial [Rattus norvegicus]","gi|31193853|gb|AC111460.6|",1213,0,"Rattus norvegicus BAC CH230-211F21 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam14828","Amnionless","Amnionless. The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.",".",".",".",".","."]
["ENSRNOG00000042230",109,9.049905997,34,2.187234898,4.137601318,2.04879464,{"v":3.63821e-15,"d":"3.64E-15"},{"v":1.0681E-14,"d":"1.07E-14"},"up","yes","RGD1307182","protein_coding","chr9:12681535-12690629:-","gi|672023703|ref|XP_006226770.2|",1209,{"v":1e-157,"d":"1.00E-157"},"PREDICTED: trem-like transcript 3 protein [Rattus norvegicus]","gi|672023702|ref|XM_006226708.2|",2136,0,"PREDICTED: Rattus norvegicus similar to RIKEN cDNA B430306N03 gene (RGD1307182), mRNA","Q6UXN2",73.6,{"v":4e-13,"d":"4.00E-13"},"Trem-like transcript 4 protein",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".","GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0038023|signaling receptor activity;",".","."]
["ENSRNOG00000005390",300,24.90799816,189,12.15845282,2.048615768,1.034649422,{"v":3.92961e-15,"d":"3.93E-15"},{"v":1.15153E-14,"d":"1.15E-14"},"up","yes","Nup210","protein_coding","chr4:123511559-123609874:-","gi|16758020|ref|NP_445774.1|",9737,0,"nuclear pore membrane glycoprotein 210 precursor [Rattus norvegicus]","gi|672050455|ref|XR_353478.2|",6941,0,"PREDICTED: Rattus norvegicus nucleoporin 210 (Nup210), transcript variant X1, misc_RNA","P11654",3709,0,"Nuclear pore membrane glycoprotein 210",".",".",".",".","pfam03154","Atrophin-1","Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.","GO:0006913|nucleocytoplasmic transport;GO:0015031|protein transport;GO:0051028|mRNA transport;GO:0065003|protein-containing complex assembly;","GO:0005635|nuclear envelope;GO:0005643|nuclear pore;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0031965|nuclear membrane;","GO:0017056|structural constituent of nuclear pore;","K14314","NUP210, GP210; nuclear pore complex protein Nup210"]
["ENSRNOG00000005810",86,7.140292805,20,1.286608764,5.549700116,2.472409816,{"v":4.66378e-15,"d":"4.66E-15"},{"v":1.36105E-14,"d":"1.36E-14"},"up","yes","Nlrc4","protein_coding","chr6:20995266-21018248:+","gi|827012496|ref|NP_001296361.1|",5285,0,"NLR family CARD domain-containing protein 4 [Rattus norvegicus]","gi|827012495|ref|NM_001309432.1|",3441,0,"Rattus norvegicus NLR family, CARD domain containing 4 (Nlrc4), mRNA","F1M649",2040,0,"NLR family CARD domain-containing protein 4",".",".",".",".","pfam05729","NACHT","NACHT domain. This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.","GO:0002218|activation of innate immune response;GO:0006915|apoptotic process;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006954|inflammatory response;GO:0010954|positive regulation of protein processing;GO:0016045|detection of bacterium;GO:0032731|positive regulation of interleukin-1 beta production;GO:0042742|defense response to bacterium;GO:0042981|regulation of apoptotic process;GO:0043065|positive regulation of apoptotic process;GO:0043281|regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045087|innate immune response;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051260|protein homooligomerization;GO:0070269|pyroptosis;GO:0097202|activation of cysteine-type endopeptidase activity;","GO:0005829|cytosol;GO:0072557|IPAF inflammasome complex;","GO:0005524|ATP binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0061133|endopeptidase activator activity;GO:0089720|caspase binding;","K12805","NLRC4, CARD12; NLR family CARD domain-containing protein 4"]
["ENSRNOG00000002273",193,16.02414548,97,6.240052504,2.567950425,1.360617351,{"v":4.78777e-15,"d":"4.79E-15"},{"v":1.39597E-14,"d":"1.40E-14"},"up","yes","Naaa","protein_coding","chr14:15777306-15796410:+","gi|58219537|ref|NP_001010967.1|",1870,0,"N-acylethanolamine-hydrolyzing acid amidase precursor [Rattus norvegicus]","gi|77736613|ref|NM_001010967.2|",1809,0,"Rattus norvegicus N-acylethanolamine acid amidase (Naaa), mRNA","Q5KTC7",721,0,"N-acylethanolamine-hydrolyzing acid amidase",".",".",".",".","pfam15508","NAAA-beta","beta subunit of N-acylethanolamine-hydrolyzing acid amidase. NAAA-beta is a family of vertebral sequences that form the beta subunit of vertebral N-acylethanolamine-hydrolyzing acid amidase, a member of the choloylglycine hydrolase acid ceramidase family. The alpha subunit is represented by family CBAH, pfam02275.","GO:0006631|fatty acid metabolic process;GO:0006670|sphingosine metabolic process;GO:0016042|lipid catabolic process;GO:0070291|N-acylethanolamine metabolic process;GO:0070292|N-acylphosphatidylethanolamine metabolic process;","GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0019898|extrinsic component of membrane;","GO:0016810|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;GO:0017040|N-acylsphingosine amidohydrolase activity;GO:0017064|fatty acid amide hydrolase activity;GO:0047412|N-(long-chain-acyl)ethanolamine deacylase activity;GO:0102121|ceramidase activity;","K13720","NAAA; N-(long-chain-acyl)ethanolamine deacylase [EC:3.5.1.60]"]
["ENSRNOG00000016420",238,19.7603452,135,8.684609155,2.275329247,1.186075322,{"v":5.50708e-15,"d":"5.51E-15"},{"v":1.59986e-14,"d":"1.60E-14"},"up","yes","Serpinb6b","protein_coding","chr17:31457834-31475176:-","gi|58866004|ref|NP_001012214.1|",1802,0,"serine (or cysteine) peptidase inhibitor, clade B, member 6b [Rattus norvegicus]","gi|58866003|ref|NM_001012214.1|",939,0,"Rattus norvegicus serine (or cysteine) peptidase inhibitor, clade B, member 6b (Serpinb6b), mRNA","Q60854",551,0,"Serpin B6","MA3388",176,{"v":2e-48,"d":"2.00E-48"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0010951|negative regulation of endopeptidase activity;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0004867|serine-type endopeptidase inhibitor activity;","K13963","SERPINB; serpin B"]
["ENSRNOG00000045679",195,16.1901988,99,6.36871338,2.542145931,1.34604685,{"v":5.79991E-15,"d":"5.80E-15"},{"v":1.68416E-14,"d":"1.68E-14"},"up","yes","Apoa1","protein_coding","chr8:46527144-46529035:+","gi|6978515|ref|NP_036870.1|",1264,{"v":1E-172,"d":"1.00E-172"},"apolipoprotein A-I preproprotein [Rattus norvegicus]","gi|298915444|emb|FQ210161.1|",888,0,"Rattus norvegicus TL0ABA33YH12 mRNA sequence","P04639",491,{"v":5e-174,"d":"5.00E-174"},"Apolipoprotein A-I",".",".",".",".","pfam01442","Apolipoprotein","Apolipoprotein A1/A4/E domain. These proteins contain several 22 residue repeats which form a pair of alpha helices. This family includes: Apolipoprotein A-I. Apolipoprotein A-IV, and Apolipoprotein E.","GO:0001932|regulation of protein phosphorylation;GO:0001935|endothelial cell proliferation;GO:0002719|negative regulation of cytokine production involved in immune response;GO:0006644|phospholipid metabolic process;GO:0006656|phosphatidylcholine biosynthetic process;GO:0006695|cholesterol biosynthetic process;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007229|integrin-mediated signaling pathway;GO:0007584|response to nutrient;GO:0008203|cholesterol metabolic process;GO:0008211|glucocorticoid metabolic process;GO:0009410|response to xenobiotic stimulus;GO:0010804|negative regulation of tumor necrosis factor-mediated signaling pathway;GO:0010873|positive regulation of cholesterol esterification;GO:0010875|positive regulation of cholesterol efflux;GO:0010898|positive regulation of triglyceride catabolic process;GO:0010903|negative regulation of very-low-density lipoprotein particle remodeling;GO:0014012|peripheral nervous system axon regeneration;GO:0015914|phospholipid transport;GO:0018158|protein oxidation;GO:0018206|peptidyl-methionine modification;GO:0019915|lipid storage;GO:0030300|regulation of intestinal cholesterol absorption;GO:0030301|cholesterol transport;GO:0030325|adrenal gland development;GO:0031100|animal organ regeneration;GO:0032489|regulation of Cdc42 protein signal transduction;GO:0032691|negative regulation of interleukin-1 beta production;GO:0033344|cholesterol efflux;GO:0033700|phospholipid efflux;GO:0034115|negative regulation of heterotypic cell-cell adhesion;GO:0034372|very-low-density lipoprotein particle remodeling;GO:0034375|high-density lipoprotein particle remodeling;GO:0034380|high-density lipoprotein particle assembly;GO:0035025|positive regulation of Rho protein signal transduction;GO:0042157|lipoprotein metabolic process;GO:0042158|lipoprotein biosynthetic process;GO:0042632|cholesterol homeostasis;GO:0043534|blood vessel endothelial cell migration;GO:0043627|response to estrogen;GO:0043691|reverse cholesterol transport;GO:0045723|positive regulation of fatty acid biosynthetic process;GO:0046470|phosphatidylcholine metabolic process;GO:0046889|positive regulation of lipid biosynthetic process;GO:0050728|negative regulation of inflammatory response;GO:0050766|positive regulation of phagocytosis;GO:0050821|protein stabilization;GO:0050919|negative chemotaxis;GO:0051006|positive regulation of lipoprotein lipase activity;GO:0051180|vitamin transport;GO:0051345|positive regulation of hydrolase activity;GO:0051346|negative regulation of hydrolase activity;GO:0051496|positive regulation of stress fiber assembly;GO:0055091|phospholipid homeostasis;GO:0060192|negative regulation of lipase activity;GO:0060354|negative regulation of cell adhesion molecule production;GO:0060761|negative regulation of response to cytokine stimulus;GO:0070328|triglyceride homeostasis;GO:0070508|cholesterol import;GO:0120009|intermembrane lipid transfer;GO:1900026|positive regulation of substrate adhesion-dependent cell spreading;GO:1902995|positive regulation of phospholipid efflux;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0009986|cell surface;GO:0030139|endocytic vesicle;GO:0031410|cytoplasmic vesicle;GO:0034361|very-low-density lipoprotein particle;GO:0034362|low-density lipoprotein particle;GO:0034363|intermediate-density lipoprotein particle;GO:0034364|high-density lipoprotein particle;GO:0034365|discoidal high-density lipoprotein particle;GO:0034366|spherical high-density lipoprotein particle;GO:0042627|chylomicron;","GO:0001540|amyloid-beta binding;GO:0005102|signaling receptor binding;GO:0005319|lipid transporter activity;GO:0005515|protein binding;GO:0005543|phospholipid binding;GO:0008035|high-density lipoprotein particle binding;GO:0008289|lipid binding;GO:0015485|cholesterol binding;GO:0019899|enzyme binding;GO:0031072|heat shock protein binding;GO:0031210|phosphatidylcholine binding;GO:0034190|apolipoprotein receptor binding;GO:0034191|apolipoprotein A-I receptor binding;GO:0042802|identical protein binding;GO:0045499|chemorepellent activity;GO:0055102|lipase inhibitor activity;GO:0060228|phosphatidylcholine-sterol O-acyltransferase activator activity;GO:0070653|high-density lipoprotein particle receptor binding;GO:0071813|lipoprotein particle binding;GO:0120020|intermembrane cholesterol transfer activity;","K08757","APOA1; apolipoprotein A-I"]
["ENSRNOG00000013981",117,9.714119281,40,2.573217527,3.775086707,1.916509781,{"v":6.14554e-15,"d":"6.15E-15"},{"v":1.7829e-14,"d":"1.78E-14"},"up","yes","Ptpn5","protein_coding","chr1:97620642-97679882:-","gi|564328503|ref|XP_006229314.1|",2716,0,"PREDICTED: tyrosine-protein phosphatase non-receptor type 5 isoform X1 [Rattus norvegicus]","gi|672036375|ref|XM_006229252.2|",3324,0,"PREDICTED: Rattus norvegicus protein tyrosine phosphatase, non-receptor type 5 (Ptpn5), transcript variant X1, mRNA","P54830",951,0,"Tyrosine-protein phosphatase non-receptor type 5","SPAC19D5.01",127,{"v":2e-29,"d":"2.00E-29"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0001934|positive regulation of protein phosphorylation;GO:0001975|response to amphetamine;GO:0002092|positive regulation of receptor internalization;GO:0006470|protein dephosphorylation;GO:0007568|aging;GO:0009410|response to xenobiotic stimulus;GO:0010976|positive regulation of neuron projection development;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0035640|exploration behavior;GO:0035902|response to immobilization stress;GO:0042307|positive regulation of protein import into nucleus;GO:0043407|negative regulation of MAP kinase activity;GO:1900273|positive regulation of long-term synaptic potentiation;GO:1901216|positive regulation of neuron death;GO:1903492|response to acetylsalicylate;GO:1903955|positive regulation of protein targeting to mitochondrion;GO:2001025|positive regulation of response to drug;","GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;GO:0008021|synaptic vesicle;GO:0016020|membrane;GO:0030424|axon;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0097060|synaptic membrane;GO:1990635|proximal dendrite;","GO:0001784|phosphotyrosine residue binding;GO:0004725|protein tyrosine phosphatase activity;GO:0019901|protein kinase binding;GO:0035254|glutamate receptor binding;GO:0042802|identical protein binding;GO:0051019|mitogen-activated protein kinase binding;","K18018","PTPN5; tyrosine-protein phosphatase non-receptor type 5 [EC:3.1.3.48]"]
["ENSRNOG00000021546",50,4.151333026,2,0.128660876,32.26569835,5.011929346,{"v":6.20574e-15,"d":"6.21E-15"},{"v":1.79955e-14,"d":"1.80E-14"},"up","yes","Sit1","protein_coding","chr5:57740218-57741838:-","gi|66730477|ref|NP_001019515.1|",859,{"v":1e-111,"d":"1.00E-111"},"signaling threshold-regulating transmembrane adapter 1 [Rattus norvegicus]","gi|66730476|ref|NM_001024344.1|",1198,0,"Rattus norvegicus signaling threshold regulating transmembrane adaptor 1 (Sit1), mRNA","Q5M869",335,{"v":4e-113,"d":"4.00E-113"},"Signaling threshold-regulating transmembrane adapter 1",".",".",".",".","pfam15330","SIT","SHP2-interacting transmembrane adaptor protein, SIT. SIT, or SHP2-interacting transmembrane adaptor protein, is a disulfide-linked dimer that regulates human T Cell activation.","GO:0002250|adaptive immune response;GO:0007165|signal transduction;GO:0043029|T cell homeostasis;GO:0050863|regulation of T cell activation;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0019900|kinase binding;",".","."]
["ENSRNOG00000006620",65,5.396732934,9,0.578973944,9.321201745,3.220515968,{"v":6.4673E-15,"d":"6.47E-15"},{"v":1.8737e-14,"d":"1.87E-14"},"up","yes","Xcr1","protein_coding","chr8:123479590-123487226:-","gi|157822209|ref|NP_001100341.1|",1587,0,"chemokine XC receptor 1 [Rattus norvegicus]","gi|157822208|ref|NM_001106871.1|",4240,0,"Rattus norvegicus chemokine (C motif) receptor 1 (Xcr1), mRNA","Q9R0M1",486,{"v":4e-158,"d":"4.00E-158"},"Chemokine XC receptor 1",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0006935|chemotaxis;GO:0006955|immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0019722|calcium-mediated signaling;GO:0034097|response to cytokine;GO:0051209|release of sequestered calcium ion into cytosol;GO:0060326|cell chemotaxis;GO:0070098|chemokine-mediated signaling pathway;","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0016493|C-C chemokine receptor activity;GO:0019957|C-C chemokine binding;","K04193","XCR1; XC chemokine receptor 1"]
["ENSRNOG00000015411",171,14.19755895,80,5.146435055,2.758717209,1.463997576,{"v":6.60761e-15,"d":"6.61E-15"},{"v":1.91002e-14,"d":"1.91E-14"},"up","yes","Apobec1","protein_coding","chr4:155800887-155827390:-","gi|148667274|gb|EDK99690.1|",1139,{"v":3e-150,"d":"3.00E-150"},"apolipoprotein B editing complex 1, isoform CRA_b, partial [Mus musculus]","gi|672050786|ref|XM_006237290.2|",898,0,"PREDICTED: Rattus norvegicus apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 (Apobec1), transcript variant X2, mRNA","P38483",473,{"v":1e-163,"d":"1.00E-163"},"C->U-editing enzyme APOBEC-1",".",".",".",".","pfam08210","APOBEC_N","APOBEC-like N-terminal domain. A mechanism of generating protein diversity is mRNA editing. Members of this family are C-to-U editing enzymes. The N-terminal domain of APOBEC-1 like proteins is the catalytic domain, while the C-terminal domain is a pseudocatalyitc domain. More specifically, the catalytic domain is a zinc dependent deaminases domain and is essential for cytidine deamination.APOBEC-3 like members contain two copies of this domain. RNA editing by APOBEC-1 requires homodimerization and this complex interacts with RNA binding proteins to from the editosome (and references therein). This family also includes the functionally homologous activation induced deaminase (AID), which is essential for the development of antibody diversity in B lymphocytes, and the sea lamprey PmCDA1 and PmCDA2, which are predicted to play an AID-like role in the adaptive immune response of jawless vertebrates. Divergent members of this family are present in various eukaryotes such as Nematostella, C. elegans, Micromonas and Emiliania, and prokaryotes such as Wolbachia and Pseudomonas brassicacearum.","GO:0006397|mRNA processing;GO:0006641|triglyceride metabolic process;GO:0006970|response to osmotic stress;GO:0009410|response to xenobiotic stimulus;GO:0009972|cytidine deamination;GO:0010043|response to zinc ion;GO:0010332|response to gamma radiation;GO:0016554|cytidine to uridine editing;GO:0016556|mRNA modification;GO:0032869|cellular response to insulin stimulus;GO:0042127|regulation of cell proliferation;GO:0042157|lipoprotein metabolic process;GO:0042158|lipoprotein biosynthetic process;GO:0042953|lipoprotein transport;GO:0045471|response to ethanol;GO:0046087|cytidine metabolic process;GO:0048255|mRNA stabilization;GO:0050790|regulation of catalytic activity;GO:0051592|response to calcium ion;GO:0051607|defense response to virus;GO:0070383|DNA cytosine deamination;GO:0080111|DNA demethylation;GO:0090209|negative regulation of triglyceride metabolic process;GO:0090310|negative regulation of methylation-dependent chromatin silencing;GO:0090366|positive regulation of mRNA modification;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0003723|RNA binding;GO:0003729|mRNA binding;GO:0004126|cytidine deaminase activity;GO:0004131|cytosine deaminase activity;GO:0005515|protein binding;GO:0008047|enzyme activator activity;GO:0008270|zinc ion binding;GO:0019904|protein domain specific binding;GO:0035925|mRNA 3'-UTR AU-rich region binding;GO:0043021|ribonucleoprotein complex binding;","K16932","APOBEC1; C->U-editing enzyme APOBEC1 [EC:3.5.4.36]"]
["ENSRNOG00000028016",171,14.19755895,80,5.146435055,2.758717209,1.463997576,{"v":6.60761e-15,"d":"6.61E-15"},{"v":1.91002e-14,"d":"1.91E-14"},"up","yes","Ncf2","protein_coding","chr13:64955503-64986277:+","gi|386655991|gb|AFJ19026.1|",2604,0,"neutrophil cytosolic factor 2 [Rattus norvegicus]","gi|386655992|gb|JN864042.1|",1581,0,"Rattus norvegicus strain BN neutrophil cytosolic factor 2 (Ncf2) mRNA, complete cds","O70145",946,0,"Neutrophil cytosol factor 2",".",".",".",".","pfam00018","SH3_1","SH3 domain. SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta barrel.","GO:0006909|phagocytosis;GO:0007568|aging;GO:0009410|response to xenobiotic stimulus;GO:0009749|response to glucose;GO:0014070|response to organic cyclic compound;GO:0014823|response to activity;GO:0032496|response to lipopolysaccharide;GO:0032570|response to progesterone;GO:0032870|cellular response to hormone stimulus;GO:0033993|response to lipid;GO:0034616|response to laminar fluid shear stress;GO:0042554|superoxide anion generation;GO:0043525|positive regulation of neuron apoptotic process;GO:0045730|respiratory burst;GO:0045777|positive regulation of blood pressure;GO:0050790|regulation of catalytic activity;GO:0055093|response to hyperoxia;","GO:0001669|acrosomal vesicle;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016020|membrane;GO:0043020|NADPH oxidase complex;","GO:0003674|molecular_function;GO:0008022|protein C-terminus binding;GO:0016175|superoxide-generating NADPH oxidase activity;GO:0016176|superoxide-generating NADPH oxidase activator activity;GO:0031267|small GTPase binding;","K08010","NCF2, P67PHOX; neutrophil cytosolic factor 2"]
["ENSRNOG00000002826",181,15.02782556,88,5.66107856,2.654587001,1.408487425,{"v":6.86424e-15,"d":"6.86E-15"},{"v":1.98331E-14,"d":"1.98E-14"},"up","yes","Hsd17b7","protein_coding","chr13:82173179-82190017:-","gi|564381646|ref|XP_006250277.1|",1801,0,"PREDICTED: 3-keto-steroid reductase isoform X1 [Rattus norvegicus]","gi|672074766|ref|XM_006250215.2|",1676,0,"PREDICTED: Rattus norvegicus hydroxysteroid (17-beta) dehydrogenase 7 (Hsd17b7), transcript variant X1, mRNA","Q62904",696,0,"3-keto-steroid reductase",".",".",".",".","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.","GO:0006695|cholesterol biosynthetic process;GO:0006703|estrogen biosynthetic process;GO:0007399|nervous system development;GO:0007420|brain development;GO:0008209|androgen metabolic process;GO:0009410|response to xenobiotic stimulus;GO:0014070|response to organic cyclic compound;GO:0021766|hippocampus development;GO:0030154|cell differentiation;GO:0032355|response to estradiol;GO:0048568|embryonic organ development;GO:0048706|embryonic skeletal system development;GO:0060135|maternal process involved in female pregnancy;GO:1990637|response to prolactin;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0000253|3-keto sterol reductase activity;GO:0004303|estradiol 17-beta-dehydrogenase activity;GO:0005148|prolactin receptor binding;GO:0047024|5alpha-androstane-3beta,17beta-diol dehydrogenase activity;GO:0072582|17-beta-hydroxysteroid dehydrogenase (NADP+) activity;","K13373","HSD17B7; 17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase [EC:1.1.1.62 1.1.1.270]"]
["ENSRNOG00000033912",124,10.29530591,45,2.894869718,3.556396974,1.83041637,{"v":6.94814e-15,"d":"6.95E-15"},{"v":2.00665e-14,"d":"2.01E-14"},"up","yes","Fcho1","protein_coding","chr16:18413363-18435104:-","gi|672079582|ref|XP_008769304.1|",4154,0,"PREDICTED: FCH domain only protein 1 isoform X1 [Rattus norvegicus]","gi|672079581|ref|XM_008771082.1|",2875,0,"PREDICTED: Rattus norvegicus FCH domain only 1 (Fcho1), transcript variant X1, mRNA","Q8K285",1484,0,"F-BAR domain only protein 1",".",".",".",".","pfam10291","muHD","Muniscin C-terminal mu homology domain. The muniscins are a family of endocytic adaptors that is conserved from yeast to humans.This C-terminal domain is structurally similar to mu homology domains, and is the region of the muniscin proteins involved in the interactions with the endocytic adaptor-scaffold proteins Ede1-eps15. This interaction influences muniscin localisation. The muniscins provide a combined adaptor-membrane-tubulation activity that is important for regulating endocytosis.","GO:0048268|clathrin coat assembly;GO:0072583|clathrin-dependent endocytosis;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005905|clathrin-coated pit;GO:0030136|clathrin-coated vesicle;","GO:0035612|AP-2 adaptor complex binding;","K20042","FCHO; F-BAR domain only protein"]
["ENSRNOG00000046309",54,4.483439668,4,0.257321753,17.42347711,4.122960658,{"v":7.33949e-15,"d":"7.34E-15"},{"v":2.11775E-14,"d":"2.12E-14"},"up","yes","Gpr68","protein_coding","chr6:120135436-120166089:-","gi|157820739|ref|NP_001101519.1|",1946,0,"ovarian cancer G-protein coupled receptor 1 [Rattus norvegicus]","gi|157820738|ref|NM_001108049.1|",2960,0,"Rattus norvegicus G protein-coupled receptor 68 (Gpr68), mRNA","Q8BFQ3",707,0,"Ovarian cancer G-protein coupled receptor 1",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0032024|positive regulation of insulin secretion;GO:0035774|positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0045656|negative regulation of monocyte differentiation;GO:0071467|cellular response to pH;GO:2001206|positive regulation of osteoclast development;","GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;","K08408","GPR68, OGR1; ovarian cancer G-protein coupled receptor 1"]
["ENSRNOG00000017403",224,18.59797196,124,7.976974335,2.331456913,1.221231768,{"v":8.5784e-15,"d":"8.58E-15"},{"v":2.46522e-14,"d":"2.47E-14"},"up","yes","Apobr","protein_coding","chr1:181168916-181173528:+","gi|564331101|ref|XP_006230381.1|",4501,0,"PREDICTED: apolipoprotein B receptor isoform X1 [Rattus norvegicus]","gi|672038542|ref|XM_006230319.2|",3814,0,"PREDICTED: Rattus norvegicus apolipoprotein B receptor (Apobr), transcript variant X1, mRNA","Q8VBT6",1183,0,"Apolipoprotein B receptor",".",".",".",".","pfam04621","ETS_PEA3_N","PEA3 subfamily ETS-domain transcription factor N terminal domain. The N terminus of the PEA3 transcription factors is implicated in transactivation and in inhibition of DNA binding. Transactivation is potentiated by activation of the Ras/MAP kinase and protein kinase A signalling cascades. The N terminal region contains conserved MAP kinase phosphorylation sites.","GO:0006641|triglyceride metabolic process;GO:0006869|lipid transport;GO:0006897|endocytosis;",".","GO:0030229|very-low-density lipoprotein particle receptor activity;",".","."]
["ENSRNOG00000014258",256,21.25482509,152,9.778226604,2.173689152,1.120145643,{"v":9.76207e-15,"d":"9.76E-15"},{"v":2.79783e-14,"d":"2.80E-14"},"up","yes","Rab32","lncRNA","chr1:4945036-4960934:-","gi|157820973|ref|NP_001102372.1|",864,{"v":3E-102,"d":"3.00E-102"},"ras-related protein Rab-32 [Rattus norvegicus]","gi|157820972|ref|NM_001108902.1|",1406,0,"Rattus norvegicus RAB32, member RAS oncogene family (Rab32), mRNA","Q9CZE3",322,{"v":2e-98,"d":"2.00E-98"},"Ras-related protein Rab-32",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0006886|intracellular protein transport;GO:0007005|mitochondrion organization;GO:0016192|vesicle-mediated transport;GO:0019882|antigen processing and presentation;GO:0032438|melanosome organization;GO:0035646|endosome to melanosome transport;GO:0072657|protein localization to membrane;GO:0090382|phagosome maturation;GO:1903232|melanosome assembly;","GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0005769|early endosome;GO:0005783|endoplasmic reticulum;GO:0005802|trans-Golgi network;GO:0012505|endomembrane system;GO:0016020|membrane;GO:0033162|melanosome membrane;GO:0042470|melanosome;GO:0044233|Mitochondria-associated ER Membrane;GO:0045335|phagocytic vesicle;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0030742|GTP-dependent protein binding;GO:0035650|AP-1 adaptor complex binding;GO:0035651|AP-3 adaptor complex binding;GO:0036461|BLOC-2 complex binding;","K07918","RAB32; Ras-related protein Rab-32"]
["ENSRNOG00000065968",51,4.234359687,3,0.192991315,21.94067488,4.455535997,{"v":1.24233E-14,"d":"1.24E-14"},{"v":3.53205E-14,"d":"3.53E-14"},"up","yes","Rn7sl1","misc_RNA","chr6:87636804-87637103:+","gi|594691438|ref|XP_007193055.1|",518,{"v":5e-63,"d":"5.00E-63"},"PREDICTED: uncharacterized protein LOC103017900 [Balaenoptera acutorostrata scammoni]","gi|527047032|tpe|HG323686.1|",300,{"v":1e-154,"d":"1.00E-154"},"TPA: Mus musculus SRP RNA for signal recognition particle RNA",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSRNOG00000013748",48,3.985279705,1,0.064330438,61.95014083,5.953035657,{"v":1.2465E-14,"d":"1.25E-14"},{"v":3.54234e-14,"d":"3.54E-14"},"up","yes","Trem3","protein_coding","chr9:12749852-12760779:-","gi|300797456|ref|NP_001178510.1|",922,{"v":5e-119,"d":"5.00E-119"},"triggering receptor expressed on myeloid cells 3 precursor [Rattus norvegicus]","gi|300797455|ref|NM_001191581.1|",893,0,"Rattus norvegicus triggering receptor expressed on myeloid cells 3 (Trem3), mRNA","Q9JKE2",100,{"v":2e-22,"d":"2.00E-22"},"Triggering receptor expressed on myeloid cells 1",".",".",".",".","pfam02666","PS_Dcarbxylase","Phosphatidylserine decarboxylase. This is a family of phosphatidylserine decarboxylases, EC:4.1.1.65.  These enzymes catalyse the reaction: Phosphatidyl-L-serine <=> phosphatidylethanolamine + CO2. Phosphatidylserine decarboxylase plays a central role in the biosynthesis of aminophospholipids by converting phosphatidylserine to phosphatidylethanolamine.","GO:0002367|cytokine production involved in immune response;GO:0030593|neutrophil chemotaxis;GO:0032602|chemokine production;GO:0045089|positive regulation of innate immune response;GO:0070945|neutrophil mediated killing of gram-negative bacterium;GO:0072672|neutrophil extravasation;","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000070502",77,6.39305286,16,1.029287011,6.211146932,2.634859697,{"v":1.56431e-14,"d":"1.56E-14"},{"v":4.42779e-14,"d":"4.43E-14"},"up","yes","ENSRNOG00000070502","lncRNA","chr5:8978744-8981492:-",".",".",".",".","gi|61675915|gb|AC102462.19|",369,0,"Mus musculus chromosome 1, clone RP24-327F2, complete sequence",".",".",".",".",".",".",".",".","pfam10326","7TM_GPCR_Str","Serpentine type 7TM GPCR chemoreceptor Str. Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.",".",".",".",".","."]
["ENSRNOG00000005807",97,8.053586071,28,1.801252269,4.471103914,2.160631076,{"v":1.64102e-14,"d":"1.64E-14"},{"v":4.63874E-14,"d":"4.64E-14"},"up","yes","Ptpn7","protein_coding","chr13:46571712-46583308:+","gi|21728414|ref|NP_663716.1|",1680,0,"tyrosine-protein phosphatase non-receptor type 7 [Rattus norvegicus]","gi|672074008|ref|XM_006249821.2|",1806,0,"PREDICTED: Rattus norvegicus protein tyrosine phosphatase, non-receptor type 7 (Ptpn7), transcript variant X2, mRNA","P49445",651,0,"Tyrosine-protein phosphatase non-receptor type 7","SPAC11E3.09",120,{"v":1e-28,"d":"1.00E-28"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0006470|protein dephosphorylation;GO:0035335|peptidyl-tyrosine dephosphorylation;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0009898|cytoplasmic side of plasma membrane;GO:0015630|microtubule cytoskeleton;GO:0072686|mitotic spindle;","GO:0004725|protein tyrosine phosphatase activity;","K18019","PTPN7; tyrosine-protein phosphatase non-receptor type 7 [EC:3.1.3.48]"]
["ENSRNOG00000066870",59,4.898572971,7,0.450313067,10.87814973,3.443361283,{"v":2.18724e-14,"d":"2.19E-14"},{"v":6.15286e-14,"d":"6.15E-14"},"up","yes","ENSRNOG00000066870","protein_coding","chr3:109505663-109535168:+","gi|15721849|gb|AAK38150.1|",3246,0,"concentrative Na+ nucleoside cotransporter [Rattus norvegicus]","gi|13928919|ref|NM_031664.1|",2575,0,"Rattus norvegicus solute carrier family 28 member 2 (Slc28a2), mRNA","Q62773",1252,0,"Sodium/nucleoside cotransporter 2","all0378",347,{"v":1E-108,"d":"1.00E-108"},"COG1972","pfam07662","Nucleos_tra2_C","Na+ dependent nucleoside transporter C-terminus. This family consists of nucleoside transport proteins. Members include a purine-specific Na+-nucleoside cotransporter localized to the bile canalicular membrane and a Na+-dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine, which also transports the anti-viral nucleoside analogues AZT and ddC. This alignment covers the C-terminus of this family of transporters.",".",".",".",".","."]
["ENSRNOG00000013572",260,21.58693174,158,10.16420923,2.123818119,1.086660221,{"v":2.67035E-14,"d":"2.67E-14"},{"v":7.47243e-14,"d":"7.47E-14"},"up","yes","Lxn","protein_coding","chr2:151727102-151733460:-","gi|14269568|ref|NP_113843.1|",1211,{"v":3E-162,"d":"3.00E-162"},"latexin [Rattus norvegicus]","gi|298888579|emb|FQ220594.1|",1088,0,"Rattus norvegicus TL0ADA42YF08 mRNA sequence","Q64361",471,{"v":9e-164,"d":"9.00E-164"},"Latexin",".",".",".",".","pfam06907","Latexin","Latexin. This family consists of several animal specific latexin proteins. Latexin is a carboxypeptidase A inhibitor and is expressed in a cell type-specific manner in both central and peripheral nervous systems in the rat.","GO:0006954|inflammatory response;GO:0010951|negative regulation of endopeptidase activity;GO:0050965|detection of temperature stimulus involved in sensory perception of pain;","GO:0005615|extracellular space;GO:0005737|cytoplasm;","GO:0008191|metalloendopeptidase inhibitor activity;GO:0008201|heparin binding;","K23594","LXN; latexin"]
["ENSRNOG00000069681",81,6.725159503,19,1.222278326,5.502150666,2.459995646,{"v":3.38746e-14,"d":"3.39E-14"},{"v":9.40502e-14,"d":"9.41E-14"},"up","yes","ENSRNOG00000069681","pseudogene","chr4:31200445-31205142:-","gi|672018004|ref|XP_008773887.1|",7451,0,"PREDICTED: LOW QUALITY PROTEIN: sterile alpha motif domain-containing protein 9-like [Rattus norvegicus]","gi|672018003|ref|XM_008775665.1|",1495,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102553788 (LOC102553788), transcript variant X1, mRNA","Q69Z37",2424,0,"Sterile alpha motif domain-containing protein 9-like",".",".",".",".","pfam00536","SAM_1","SAM domain (Sterile alpha motif). It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.",".",".",".",".","."]
["ENSRNOG00000000239",176,14.61269225,87,5.596748122,2.610925476,1.384561279,{"v":3.46701E-14,"d":"3.47E-14"},{"v":9.61335e-14,"d":"9.61E-14"},"up","yes","Ccl7","protein_coding","chr10:67016446-67018303:+","gi|56090537|ref|NP_001007613.1|",447,{"v":1E-52,"d":"1.00E-52"},"C-C motif chemokine 7 precursor [Rattus norvegicus]","gi|56090536|ref|NM_001007612.1|",807,0,"Rattus norvegicus chemokine (C-C motif) ligand 7 (Ccl7), mRNA","Q9QXY8",176,{"v":4e-54,"d":"4.00E-54"},"C-C motif chemokine 7",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0002548|monocyte chemotaxis;GO:0006954|inflammatory response;GO:0007010|cytoskeleton organization;GO:0007186|G protein-coupled receptor signaling pathway;GO:0008360|regulation of cell shape;GO:0010332|response to gamma radiation;GO:0030335|positive regulation of cell migration;GO:0030593|neutrophil chemotaxis;GO:0043547|positive regulation of GTPase activity;GO:0048245|eosinophil chemotaxis;GO:0048247|lymphocyte chemotaxis;GO:0070098|chemokine-mediated signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071361|cellular response to ethanol;GO:2000503|positive regulation of natural killer cell chemotaxis;","GO:0005615|extracellular space;","GO:0008009|chemokine activity;GO:0008201|heparin binding;GO:0031726|CCR1 chemokine receptor binding;GO:0031727|CCR2 chemokine receptor binding;GO:0048020|CCR chemokine receptor binding;","K05509","CCL7; C-C motif chemokine 7"]
["ENSRNOG00000003666",72,5.977919558,14,0.900626135,6.637515089,2.730643236,{"v":3.67893E-14,"d":"3.68E-14"},{"v":1.01745E-13,"d":"1.02E-13"},"up","yes","Jchain","protein_coding","chr14:19538952-19546298:+","gi|149033720|gb|EDL88516.1|",844,{"v":2E-109,"d":"2.00E-109"},"immunoglobulin joining chain [Rattus norvegicus]","gi|67678280|gb|BC097960.1|",1237,0,"Rattus norvegicus immunoglobulin joining chain, mRNA (cDNA clone IMAGE:7384980)","P01592",305,{"v":1e-101,"d":"1.00E-101"},"Immunoglobulin J chain",".",".",".",".","pfam15097","Ig_J_chain","Immunoglobulin J chain.","GO:0001895|retina homeostasis;GO:0002250|adaptive immune response;GO:0003094|glomerular filtration;GO:0019731|antibacterial humoral response;GO:0045087|innate immune response;GO:0060267|positive regulation of respiratory burst;GO:0065003|protein-containing complex assembly;","GO:0005615|extracellular space;GO:0071748|monomeric IgA immunoglobulin complex;GO:0071750|dimeric IgA immunoglobulin complex;GO:0071751|secretory IgA immunoglobulin complex;GO:0071752|secretory dimeric IgA immunoglobulin complex;GO:0071756|pentameric IgM immunoglobulin complex;","GO:0003697|single-stranded DNA binding;GO:0019862|IgA binding;GO:0030674|protein binding, bridging;GO:0031210|phosphatidylcholine binding;GO:0034987|immunoglobulin receptor binding;GO:0042803|protein homodimerization activity;GO:0042834|peptidoglycan binding;",".","."]
["ENSRNOG00000065679",46,3.819226384,1,0.064330438,59.36888496,5.891635112,{"v":4.32309e-14,"d":"4.32E-14"},{"v":1.18994e-13,"d":"1.19E-13"},"up","yes","ENSRNOG00000065679","protein_coding","chr15:27521496-27586880:+","gi|6724235|gb|AAF26903.1|AF196266_1",858,{"v":1e-111,"d":"1.00E-111"},"T cell receptor J delta 2 [Rattus norvegicus]","gi|68534400|gb|BC099216.1|",1097,0,"Rattus norvegicus similar to T cell receptor V delta 6, mRNA (cDNA clone MGC:116392 IMAGE:7384680), complete cds","B7Z8K6",231,{"v":6e-73,"d":"6.00E-73"},"T-cell receptor delta chain C region",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.",".",".",".",".","."]
["ENSRNOG00000011205",49,4.068306366,3,0.192991315,21.08025625,4.3978205,{"v":4.84696e-14,"d":"4.85E-14"},{"v":1.32899E-13,"d":"1.33E-13"},"up","yes","Ccl3","protein_coding","chr10:68451388-68452938:-","gi|40254794|ref|NP_037157.2|",493,{"v":8e-60,"d":"8.00E-60"},"C-C motif chemokine 3 precursor [Rattus norvegicus]","gi|40254793|ref|NM_013025.2|",751,0,"Rattus norvegicus chemokine (C-C motif) ligand 3 (Ccl3), mRNA","P50229",194,{"v":3e-61,"d":"3.00E-61"},"C-C motif chemokine 3",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0000165|MAPK cascade;GO:0001649|osteoblast differentiation;GO:0001775|cell activation;GO:0002548|monocyte chemotaxis;GO:0006468|protein phosphorylation;GO:0006816|calcium ion transport;GO:0006874|cellular calcium ion homeostasis;GO:0006887|exocytosis;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0007010|cytoskeleton organization;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007267|cell-cell signaling;GO:0008360|regulation of cell shape;GO:0009410|response to xenobiotic stimulus;GO:0009636|response to toxic substance;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010818|T cell chemotaxis;GO:0014808|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0019722|calcium-mediated signaling;GO:0023052|signaling;GO:0030335|positive regulation of cell migration;GO:0030502|negative regulation of bone mineralization;GO:0030593|neutrophil chemotaxis;GO:0030595|leukocyte chemotaxis;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0043308|eosinophil degranulation;GO:0043491|protein kinase B signaling;GO:0043525|positive regulation of neuron apoptotic process;GO:0043547|positive regulation of GTPase activity;GO:0043615|astrocyte cell migration;GO:0043922|negative regulation by host of viral transcription;GO:0045671|negative regulation of osteoclast differentiation;GO:0045672|positive regulation of osteoclast differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048245|eosinophil chemotaxis;GO:0048246|macrophage chemotaxis;GO:0048247|lymphocyte chemotaxis;GO:0050729|positive regulation of inflammatory response;GO:0050795|regulation of behavior;GO:0050850|positive regulation of calcium-mediated signaling;GO:0050918|positive chemotaxis;GO:0051897|positive regulation of protein kinase B signaling;GO:0051928|positive regulation of calcium ion transport;GO:0051930|regulation of sensory perception of pain;GO:0070098|chemokine-mediated signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070723|response to cholesterol;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071407|cellular response to organic cyclic compound;GO:0071621|granulocyte chemotaxis;GO:2000503|positive regulation of natural killer cell chemotaxis;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004672|protein kinase activity;GO:0004698|calcium-dependent protein kinase C activity;GO:0008009|chemokine activity;GO:0008201|heparin binding;GO:0016004|phospholipase activator activity;GO:0016301|kinase activity;GO:0031726|CCR1 chemokine receptor binding;GO:0031730|CCR5 chemokine receptor binding;GO:0042056|chemoattractant activity;GO:0042802|identical protein binding;GO:0048020|CCR chemokine receptor binding;","K05408","CCL3; C-C motif chemokine 3"]
["ENSRNOG00000020751",264,21.91903838,165,10.6145223,2.065004694,1.046145061,{"v":1.0244E-13,"d":"1.02E-13"},{"v":2.77078e-13,"d":"2.77E-13"},"up","yes","Rdm1","protein_coding","chr10:86539553-86573034:+","gi|157786698|ref|NP_001099312.1|",1196,{"v":1e-159,"d":"1.00E-159"},"RAD52 motif-containing protein 1 [Rattus norvegicus]","gi|157786697|ref|NM_001105842.1|",992,0,"Rattus norvegicus RAD52 motif containing 1 (Rdm1), mRNA","Q9CQK3",414,{"v":4e-141,"d":"4.00E-141"},"RAD52 motif-containing protein 1",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.",".","GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0003723|RNA binding;","K10874","RDM1, RAD52B; RAD52 motif-containing protein 1"]
["ENSRNOG00000014124",190,15.7750655,101,6.497374257,2.427913935,1.279717282,{"v":1.24056e-13,"d":"1.24E-13"},{"v":3.33991E-13,"d":"3.34E-13"},"up","yes","Nod2","protein_coding","chr19:18382439-18417177:-","gi|672084373|ref|XP_008770592.1|",4952,0,"PREDICTED: nucleotide-binding oligomerization domain-containing protein 2 isoform X1 [Rattus norvegicus]","gi|672084376|ref|XM_008772372.1|",3070,0,"PREDICTED: Rattus norvegicus nucleotide-binding oligomerization domain containing 2 (Nod2), transcript variant X3, mRNA","Q8K3Z0",1791,0,"Nucleotide-binding oligomerization domain-containing protein 2",".",".",".",".","pfam05729","NACHT","NACHT domain. This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.","GO:0002221|pattern recognition receptor signaling pathway;GO:0002227|innate immune response in mucosa;GO:0002253|activation of immune response;GO:0002606|positive regulation of dendritic cell antigen processing and presentation;GO:0002710|negative regulation of T cell mediated immunity;GO:0002720|positive regulation of cytokine production involved in immune response;GO:0002732|positive regulation of dendritic cell cytokine production;GO:0002830|positive regulation of type 2 immune response;GO:0002862|negative regulation of inflammatory response to antigenic stimulus;GO:0002925|positive regulation of humoral immune response mediated by circulating immunoglobulin;GO:0006963|positive regulation of antibacterial peptide biosynthetic process;GO:0006965|positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria;GO:0007584|response to nutrient;GO:0008284|positive regulation of cell proliferation;GO:0016045|detection of bacterium;GO:0030277|maintenance of gastrointestinal epithelium;GO:0031398|positive regulation of protein ubiquitination;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0032494|response to peptidoglycan;GO:0032495|response to muramyl dipeptide;GO:0032496|response to lipopolysaccharide;GO:0032498|detection of muramyl dipeptide;GO:0032689|negative regulation of interferon-gamma production;GO:0032695|negative regulation of interleukin-12 production;GO:0032701|negative regulation of interleukin-18 production;GO:0032703|negative regulation of interleukin-2 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032733|positive regulation of interleukin-10 production;GO:0032735|positive regulation of interleukin-12 production;GO:0032740|positive regulation of interleukin-17 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032874|positive regulation of stress-activated MAPK cascade;GO:0034136|negative regulation of toll-like receptor 2 signaling pathway;GO:0035556|intracellular signal transduction;GO:0042742|defense response to bacterium;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043330|response to exogenous dsRNA;GO:0043406|positive regulation of MAP kinase activity;GO:0043410|positive regulation of MAPK cascade;GO:0043552|positive regulation of phosphatidylinositol 3-kinase activity;GO:0045087|innate immune response;GO:0045089|positive regulation of innate immune response;GO:0045747|positive regulation of Notch signaling pathway;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046330|positive regulation of JNK cascade;GO:0050679|positive regulation of epithelial cell proliferation;GO:0050727|regulation of inflammatory response;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050766|positive regulation of phagocytosis;GO:0050830|defense response to Gram-positive bacterium;GO:0050871|positive regulation of B cell activation;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051353|positive regulation of oxidoreductase activity;GO:0051770|positive regulation of nitric-oxide synthase biosynthetic process;GO:0060585|positive regulation of prostaglandin-endoperoxide synthase activity;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070431|nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0071222|cellular response to lipopolysaccharide;GO:0071224|cellular response to peptidoglycan;GO:0071225|cellular response to muramyl dipeptide;GO:0071407|cellular response to organic cyclic compound;GO:0071639|positive regulation of monocyte chemotactic protein-1 production;GO:0090022|regulation of neutrophil chemotaxis;GO:1900017|positive regulation of cytokine production involved in inflammatory response;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1902523|positive regulation of protein K63-linked ubiquitination;GO:1904417|positive regulation of xenophagy;GO:2000110|negative regulation of macrophage apoptotic process;GO:2000363|positive regulation of prostaglandin-E synthase activity;","GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016323|basolateral plasma membrane;GO:0031982|vesicle;GO:0032991|protein-containing complex;GO:0045335|phagocytic vesicle;GO:0046658|anchored component of plasma membrane;","GO:0003779|actin binding;GO:0019899|enzyme binding;GO:0019901|protein kinase binding;GO:0030544|Hsp70 protein binding;GO:0032500|muramyl dipeptide binding;GO:0038187|pattern recognition receptor activity;GO:0042834|peptidoglycan binding;GO:0044877|protein-containing complex binding;GO:0050700|CARD domain binding;GO:0051879|Hsp90 protein binding;","K10165","NOD2, CARD15; nucleotide-binding oligomerization domain-containing protein 2"]
["ENSRNOG00000025584",210,17.43559871,118,7.590991706,2.296880221,1.199675624,{"v":1.28827E-13,"d":"1.29E-13"},{"v":3.46398e-13,"d":"3.46E-13"},"up","yes","Agap2","protein_coding","chr7:62897282-62914295:+","gi|259155312|ref|NP_075415.2|",3950,0,"arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 [Rattus norvegicus]","gi|259155311|ref|NM_023026.2|",4884,0,"Rattus norvegicus ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 (Agap2), mRNA","Q8CGU4",1526,0,"Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2","SPAC824.09c",94.4,{"v":2E-19,"d":"2.00E-19"},"COG5347","pfam01412","ArfGap","Putative GTPase activating protein for Arf. Putative zinc fingers with GTPase activating proteins (GAPs) towards the small GTPase, Arf. The GAP of ARD1 stimulates GTPase hydrolysis for ARD1 but not ARFs.","GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0016197|endosomal transport;GO:0030036|actin cytoskeleton organization;GO:0032147|activation of protein kinase activity;GO:0033601|positive regulation of mammary gland epithelial cell proliferation;GO:0042177|negative regulation of protein catabolic process;GO:0043066|negative regulation of apoptotic process;GO:0043524|negative regulation of neuron apoptotic process;GO:0043551|regulation of phosphatidylinositol 3-kinase activity;GO:0045860|positive regulation of protein kinase activity;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046427|positive regulation of JAK-STAT cascade;GO:0060749|mammary gland alveolus development;GO:2001240|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005829|cytosol;GO:0090543|Flemming body;","GO:0003924|GTPase activity;GO:0005096|GTPase activator activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0005525|GTP binding;GO:0019901|protein kinase binding;GO:0030295|protein kinase activator activity;GO:0035014|phosphatidylinositol 3-kinase regulator activity;GO:0046872|metal ion binding;","K17848","AGAP2; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2"]
["ENSRNOG00000007495",149,12.37097242,68,4.374469797,2.827993561,1.499778835,{"v":1.3115E-13,"d":"1.31E-13"},{"v":3.52496e-13,"d":"3.52E-13"},"up","yes","ENSRNOG00000007495","protein_coding","chrX:37234294-37276708:-","gi|16758124|ref|NP_445847.1|",366,{"v":5e-41,"d":"5.00E-41"},"small muscular protein [Rattus norvegicus]","gi|672087512|ref|XM_006256945.2|",654,0,"PREDICTED: Rattus norvegicus small muscle protein, X-linked (Smpx), transcript variant X1, mRNA","Q925F0",145,{"v":2e-42,"d":"2.00E-42"},"Small muscular protein",".",".",".",".","pfam15355","Chisel","Stretch-responsive small skeletal muscle X protein, Chisel. The murine X-linked gene Chisel (Csl/Smpx) is selectively expressed in cardiac and skeletal muscle cells. It localizes to the costameric cytoskeleton of muscle cells through its association with focal adhesion proteins, where it may participate in regulating the dynamics of actin through the Rac1/p38 kinase pathway. Thus it is implicated in the maintenance of muscle integrity and in responses to biomechanical stress.",".","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005927|muscle tendon junction;GO:0031430|M band;GO:0043034|costamere;GO:0043292|contractile fiber;",".","K24209","SMPX; small muscular protein"]
["ENSRNOG00000058775",54,4.483439668,6,0.385982629,11.61565141,3.537998158,{"v":1.50207e-13,"d":"1.50E-13"},{"v":4.01858e-13,"d":"4.02E-13"},"up","yes","Ly49s7","protein_coding","chr4:164761855-164779735:-","gi|57222316|ref|NP_001009494.1|",1336,0,"Ly49 stimulatory receptor 7 [Rattus norvegicus]","gi|57222315|ref|NM_001009494.1|",1054,0,"Rattus norvegicus Ly49 stimulatory receptor 7 (Ly49s7), mRNA","Q60652",300,{"v":1e-98,"d":"1.00E-98"},"Killer cell lectin-like receptor 5",".",".",".",".","pfam08391","Ly49","Ly49-like protein, N-terminal region. The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000061595",75,6.226999539,17,1.093617449,5.693946767,2.509429005,{"v":1.58914e-13,"d":"1.59E-13"},{"v":4.23557E-13,"d":"4.24E-13"},"up","yes","Tfec","protein_coding","chr4:45107641-45180236:-","gi|158187526|ref|NP_071774.1|",1528,0,"transcription factor EC [Rattus norvegicus]","gi|158187525|ref|NM_022379.1|",1596,0,"Rattus norvegicus transcription factor EC (Tfec), mRNA","Q63302",593,0,"Transcription factor EC",".",".",".",".","pfam11851","DUF3371","Domain of unknown function (DUF3371). This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is typically between 125 to 142 amino acids in length.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0034605|cellular response to heat;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;GO:0005654|nucleoplasm;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0046983|protein dimerization activity;GO:1990837|sequence-specific double-stranded DNA binding;","K15591","TFEC; transcription factor EC"]
["ENSRNOG00000067312",58,4.81554631,8,0.514643505,9.357052521,3.226054151,{"v":1.72671e-13,"d":"1.73E-13"},{"v":4.59458E-13,"d":"4.59E-13"},"up","yes","ENSRNOG00000067312","lncRNA","chr4:162553439-162571574:+","gi|208879432|ref|NP_001129159.1|",195,{"v":5e-13,"d":"5.00E-13"},"killer cell lectin-like receptor subfamily B member 1A [Rattus norvegicus]","gi|672051292|ref|XR_592300.1|",3516,0,"PREDICTED: Rattus norvegicus killer cell lectin-like receptor subfamily B member 1C (LOC100362418), transcript variant X1, ncRNA","P27811",76.6,{"v":1E-13,"d":"1.00E-13"},"Killer cell lectin-like receptor subfamily B member 1A",".",".",".",".","pfam08508","DUF1746","Fungal domain of unknown function (DUF1746). This is a fungal domain of unknown function.",".",".",".",".","."]
["ENSRNOG00000000433",270,22.41719834,172,11.06483537,2.02598571,1.018623999,{"v":1.85433e-13,"d":"1.85E-13"},{"v":4.92391e-13,"d":"4.92E-13"},"up","yes","Prrt1","protein_coding","chr20:4117957-4121600:-","gi|564396747|ref|XP_006256043.1|",903,{"v":5e-111,"d":"5.00E-111"},"PREDICTED: proline-rich transmembrane protein 1 isoform X2 [Rattus norvegicus]","gi|58477189|gb|BC089986.1|",1533,0,"Rattus norvegicus proline-rich transmembrane protein 1, mRNA (cDNA clone IMAGE:7318446), complete cds","Q6MG82",161,{"v":2e-42,"d":"2.00E-42"},"Proline-rich transmembrane protein 1",".",".",".",".","pfam04505","Dispanin","Interferon-induced transmembrane protein. This family includes the human leukocyte antigen CD225, which is an interferon inducible transmembrane protein, and is associated with interferon induced cell growth suppression.","GO:0006468|protein phosphorylation;GO:0007611|learning or memory;GO:0008104|protein localization;GO:0034394|protein localization to cell surface;GO:0050808|synapse organization;GO:0060291|long-term synaptic potentiation;GO:0060292|long-term synaptic depression;GO:2000311|regulation of AMPA receptor activity;","GO:0016020|membrane;GO:0030672|synaptic vesicle membrane;GO:0098839|postsynaptic density membrane;GO:0098978|glutamatergic synapse;GO:0099055|integral component of postsynaptic membrane;","GO:0030545|receptor regulator activity;GO:0042802|identical protein binding;","K23896","PRRT1; proline-rich transmembrane protein 1"]
["ENSRNOG00000027855",47,3.902253045,3,0.192991315,20.21983763,4.337699507,{"v":1.89619e-13,"d":"1.90E-13"},{"v":5.03088e-13,"d":"5.03E-13"},"up","yes","ENSRNOG00000027855","protein_coding","chr1:69616601-69660558:-","gi|625288029|ref|XP_007635741.1|",2046,0,"PREDICTED: LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily B member 3 isoform X2 [Cricetulus griseus]","gi|17105353|ref|NM_057199.1|",1042,0,"Rattus norvegicus natural cytotoxicity triggering receptor 1 (Ncr1), mRNA","Q9Z0H5",654,0,"Natural cytotoxicity triggering receptor 1",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0002446|neutrophil mediated immunity;GO:0033031|positive regulation of neutrophil apoptotic process;GO:0035457|cellular response to interferon-alpha;GO:0038093|Fc receptor signaling pathway;GO:0042119|neutrophil activation;GO:0071222|cellular response to lipopolysaccharide;GO:0071346|cellular response to interferon-gamma;GO:0071354|cellular response to interleukin-6;GO:0071356|cellular response to tumor necrosis factor;GO:0097011|cellular response to granulocyte macrophage colony-stimulating factor stimulus;GO:1903209|positive regulation of oxidative stress-induced cell death;","GO:0005886|plasma membrane;","GO:0019766|IgA receptor activity;GO:0019862|IgA binding;","K06513","FCAR, CD89; CD89 antigen"]
["ENSRNOG00000005667",124,10.29530591,50,3.216521909,3.200757276,1.678413277,{"v":2.31123e-13,"d":"2.31E-13"},{"v":6.10672e-13,"d":"6.11E-13"},"up","yes","Astn1","protein_coding","chr13:70537703-70855440:+","gi|149058301|gb|EDM09458.1|",6670,0,"rCG46046 [Rattus norvegicus]","gi|282158056|ref|NM_001170603.1|",7132,0,"Rattus norvegicus astrotactin 1 (Astn1), mRNA","Q61137",2539,0,"Astrotactin-1",".",".",".",".","pfam14670","FXa_inhibition","Coagulation Factor Xa inhibitory site. This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.","GO:0001764|neuron migration;GO:0007158|neuron cell-cell adhesion;GO:0007626|locomotory behavior;GO:0016477|cell migration;GO:0098609|cell-cell adhesion;","GO:0005768|endosome;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;",".","K24479","ASTN; astrotactin"]
["ENSRNOG00000014018",165,13.69939899,82,5.275095931,2.596995233,1.376843366,{"v":2.71665e-13,"d":"2.72E-13"},{"v":7.15427E-13,"d":"7.15E-13"},"up","yes","St8sia1","protein_coding","chr4:175789947-175920708:-","gi|397787574|ref|NP_036945.2|",1927,0,"alpha-N-acetylneuraminide alpha-2,8-sialyltransferase [Rattus norvegicus]","gi|397787573|ref|NM_012813.2|",1465,0,"Rattus norvegicus ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 (St8sia1), mRNA","Q64687",719,0,"Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase",".",".",".",".","pfam00777","Glyco_transf_29","Glycosyltransferase family 29 (sialyltransferase). Members of this family belong to glycosyltransferase family 29.","GO:0006486|protein glycosylation;GO:0006491|N-glycan processing;GO:0008284|positive regulation of cell proliferation;GO:0009311|oligosaccharide metabolic process;GO:0034605|cellular response to heat;GO:0097503|sialylation;","GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;","GO:0003828|alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity;GO:0008373|sialyltransferase activity;","K03371","SIAT8A; alpha-N-acetyl-neuraminate alpha-2,8-sialyltransferase (sialyltransferase 8A) [EC:2.4.99.8]"]
["ENSRNOG00000013872",271,22.500225,174,11.19349624,2.01011592,1.007278702,{"v":2.77788e-13,"d":"2.78E-13"},{"v":7.30347E-13,"d":"7.30E-13"},"up","yes","P2ry14","protein_coding","chr2:143372697-143413141:-","gi|564336567|ref|XP_006232458.1|",1685,0,"PREDICTED: P2Y purinoceptor 14 isoform X1 [Rattus norvegicus]","gi|672042325|ref|XM_006232396.2|",1659,0,"PREDICTED: Rattus norvegicus purinergic receptor P2Y, G-protein coupled, 14 (P2ry14), transcript variant X2, mRNA","Q9ESG6",593,0,"P2Y purinoceptor 14",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0006955|immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0035589|G protein-coupled purinergic nucleotide receptor signaling pathway;GO:0061484|hematopoietic stem cell homeostasis;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0045028|G protein-coupled purinergic nucleotide receptor activity;","K04299","P2RY14; P2Y purinoceptor 14"]
["ENSRNOG00000063508",43,3.570146403,1,0.064330438,55.49700116,5.794337911,{"v":2.83462e-13,"d":"2.83E-13"},{"v":7.44652e-13,"d":"7.45E-13"},"up","yes","ENSRNOG00000063508","protein_coding","chr17:45622444-45643353:-","gi|135527|sp|P06335.1|TCC4_MOUSE",665,{"v":1e-85,"d":"1.00E-85"},"RecName: Full=T-cell receptor gamma chain C region 5/10-13","gi|388240393|dbj|AP012433.1|",331,{"v":1e-171,"d":"1.00E-171"},"Rattus norvegicus DNA, BAC clone: RNB1-056G15, strain: F344/Stm, complete sequence","P06335",260,{"v":3e-87,"d":"3.00E-87"},"T-cell receptor gamma chain C region 5/10-13",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.",".",".",".",".","."]
["ENSRNOG00000001908",115,9.54806596,44,2.83053928,3.3732321,1.754131588,{"v":3.32081e-13,"d":"3.32E-13"},{"v":8.69162e-13,"d":"8.69E-13"},"up","yes","Klhl6","protein_coding","chr11:80970917-81009677:+","gi|157786760|ref|NP_001099337.1|",3338,0,"kelch-like protein 6 [Rattus norvegicus]","gi|157786759|ref|NM_001105867.1|",2415,0,"Rattus norvegicus kelch-like family member 6 (Klhl6), mRNA","Q6V595",1277,0,"Kelch-like protein 6",".",".",".",".","pfam07707","BACK","BTB And C-terminal Kelch. This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).","GO:0002467|germinal center formation;GO:0009617|response to bacterium;GO:0050853|B cell receptor signaling pathway;",".",".","K10444","KLHL6; kelch-like protein 6"]
["ENSRNOG00000054404",44,3.653173063,0,0.032165219,113.5752582,6.827504775,{"v":3.4184e-13,"d":"3.42E-13"},{"v":8.93606e-13,"d":"8.94E-13"},"up","yes","ENSRNOG00000054404","protein_coding","chr11:55280418-55303827:+","gi|564314408|ref|XP_003752561.2|",1455,0,"PREDICTED: OX-2 membrane glycoprotein-like isoform X1 [Rattus norvegicus]","gi|672026026|ref|XM_003752513.3|",1354,0,"PREDICTED: Rattus norvegicus similar to OX-2 membrane glycoprotein precursor (MRC OX-2 antigen) (CD200 antigen) (LOC685716), transcript variant X1, mRNA","O54901",79.3,{"v":3e-15,"d":"3.00E-15"},"OX-2 membrane glycoprotein",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".","GO:0016021|integral component of membrane;",".","K06556","CD200; CD200 antigen"]
["ENSRNOG00000063482",44,3.653173063,0,0.032165219,113.5752582,6.827504775,{"v":3.4184e-13,"d":"3.42E-13"},{"v":8.93606e-13,"d":"8.94E-13"},"up","yes","Mcpt9","protein_coding","chr15:29799357-29860148:+","gi|149064036|gb|EDM14306.1|",1293,{"v":6e-178,"d":"6.00E-178"},"rCG23443, isoform CRA_a [Rattus norvegicus]","gi|1698703|gb|U67912.1|RNU67912",777,0,"Rattus norvegicus mast cell protease 9 (RMCP-9) mRNA, partial cds","Q06606",474,{"v":2e-168,"d":"2.00E-168"},"Granzyme-like protein 2","VC1200",75.5,{"v":1E-14,"d":"1.00E-14"},"COG5640","pfam00089","Trypsin","Trypsin.",".",".",".",".","."]
["ENSRNOG00000018906",209,17.35257205,120,7.719652582,2.247843652,1.168541693,{"v":4.5914E-13,"d":"4.59E-13"},{"v":1.19196e-12,"d":"1.19E-12"},"up","yes","Ghdc","protein_coding","chr10:85693616-85697865:-","gi|300793702|ref|NP_001178580.1|",2649,0,"GH3 domain-containing protein precursor [Rattus norvegicus]","gi|300793701|ref|NM_001191651.1|",2156,0,"Rattus norvegicus GH3 domain containing (Ghdc), mRNA","Q99J23",879,0,"GH3 domain-containing protein",".",".",".",".","pfam03321","GH3","GH3 auxin-responsive promoter.",".","GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;","GO:0016881|acid-amino acid ligase activity;",".","."]
["ENSRNOG00000012439",217,18.01678533,127,8.169965649,2.205246155,1.140939702,{"v":4.67526e-13,"d":"4.68E-13"},{"v":1.21225E-12,"d":"1.21E-12"},"up","yes","Bid","protein_coding","chr4:154113198-154134720:-","gi|12083631|ref|NP_073175.1|",1035,{"v":7e-134,"d":"7.00E-134"},"BH3-interacting domain death agonist [Rattus norvegicus]","gi|157041210|dbj|D89804.1|",1930,0,"Rattus norvegicus mRNA for desmocollin type 4, complete cds","Q9JLT6",403,{"v":2e-135,"d":"2.00E-135"},"BH3-interacting domain death agonist",".",".",".",".","pfam06393","BID","BH3 interacting domain (BID). BID is a member of the BCL-2 superfamily of proteins are key regulators of programmed cell death, hence this family is related to pfam00452. BID is a pro-apoptotic member of the Bcl-2 superfamily and as such posses the ability to target intracellular membranes and contains the BH3 death domain. The activity of BID is regulated by a Caspase 8-mediated cleavage event, exposing the BH3 domain and significantly changing the surface charge and hydrophobicity, which causes a change of cellular localisation.","GO:0001836|release of cytochrome c from mitochondria;GO:0002931|response to ischemia;GO:0006626|protein targeting to mitochondrion;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007420|brain development;GO:0008637|apoptotic mitochondrial changes;GO:0010918|positive regulation of mitochondrial membrane potential;GO:0031334|positive regulation of protein complex assembly;GO:0032355|response to estradiol;GO:0034263|positive regulation of autophagy in response to ER overload;GO:0034349|glial cell apoptotic process;GO:0042127|regulation of cell proliferation;GO:0042775|mitochondrial ATP synthesis coupled electron transport;GO:0042981|regulation of apoptotic process;GO:0043065|positive regulation of apoptotic process;GO:0065003|protein-containing complex assembly;GO:0090150|establishment of protein localization to membrane;GO:0090200|positive regulation of release of cytochrome c from mitochondria;GO:0097191|extrinsic apoptotic signaling pathway;GO:0097284|hepatocyte apoptotic process;GO:0097345|mitochondrial outer membrane permeabilization;GO:0097435|supramolecular fiber organization;GO:1902108|regulation of mitochondrial membrane permeability involved in apoptotic process;GO:1902230|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:2000045|regulation of G1/S transition of mitotic cell cycle;GO:2000271|positive regulation of fibroblast apoptotic process;GO:2001235|positive regulation of apoptotic signaling pathway;GO:2001238|positive regulation of extrinsic apoptotic signaling pathway;GO:2001244|positive regulation of intrinsic apoptotic signaling pathway;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0005829|cytosol;GO:0016020|membrane;GO:0032592|integral component of mitochondrial membrane;","GO:0005515|protein binding;GO:0031625|ubiquitin protein ligase binding;","K04726","BID; BH3 interacting domain death agonist"]
["ENSRNOG00000010819",117,9.714119281,46,2.959200157,3.282684093,1.71487592,{"v":4.88712e-13,"d":"4.89E-13"},{"v":1.26564E-12,"d":"1.27E-12"},"up","yes","Hspa4l","protein_coding","chr2:123740384-123793084:+","gi|564336295|ref|XP_006232359.1|",5360,0,"PREDICTED: heat shock 70 kDa protein 4L isoform X2 [Rattus norvegicus]","gi|672042082|ref|XM_006232297.2|",4150,0,"PREDICTED: Rattus norvegicus heat shock protein 4-like (Hspa4l), transcript variant X1, mRNA","P48722",1717,0,"Heat shock 70 kDa protein 4L","SPAC110.04c",454,{"v":8e-143,"d":"8.00E-143"},"COG0443","pfam00012","HSP70","Hsp70 protein. Hsp70 chaperones help to fold many proteins. Hsp70 assisted folding involves repeated cycles of substrate binding and release. Hsp70 activity is ATP dependent. Hsp70 proteins are made up of two regions: the amino terminus is the ATPase domain and the carboxyl terminus is the substrate binding region.","GO:0006457|protein folding;GO:0006986|response to unfolded protein;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0005524|ATP binding;","K09485","HSP110; heat shock protein 110kDa"]
["ENSRNOG00000004649",222,18.43191864,132,8.49161784,2.170601525,1.118094903,{"v":6.05569e-13,"d":"6.06E-13"},{"v":1.55131E-12,"d":"1.55E-12"},"up","yes","Il1b","protein_coding","chr3:116577010-116583415:-","gi|158186736|ref|NP_113700.2|",1243,{"v":6e-165,"d":"6.00E-165"},"interleukin-1 beta precursor [Rattus norvegicus]","gi|158186735|ref|NM_031512.2|",1209,0,"Rattus norvegicus interleukin 1 beta (Il1b), mRNA","Q63264",479,{"v":4E-165,"d":"4.00E-165"},"Interleukin-1 beta",".",".",".",".","pfam00340","IL1","Interleukin-1 / 18. This family includes interleukin-1 and interleukin-18.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0000165|MAPK cascade;GO:0001660|fever generation;GO:0001666|response to hypoxia;GO:0001934|positive regulation of protein phosphorylation;GO:0002439|chronic inflammatory response to antigenic stimulus;GO:0002526|acute inflammatory response;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007584|response to nutrient;GO:0007611|learning or memory;GO:0007613|memory;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0009408|response to heat;GO:0009410|response to xenobiotic stimulus;GO:0009743|response to carbohydrate;GO:0010193|response to ozone;GO:0010243|response to organonitrogen compound;GO:0010332|response to gamma radiation;GO:0010573|vascular endothelial growth factor production;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010718|positive regulation of epithelial to mesenchymal transition;GO:0010829|negative regulation of glucose transmembrane transport;GO:0010942|positive regulation of cell death;GO:0014050|negative regulation of glutamate secretion;GO:0014070|response to organic cyclic compound;GO:0019221|cytokine-mediated signaling pathway;GO:0030213|hyaluronan biosynthetic process;GO:0030335|positive regulation of cell migration;GO:0030593|neutrophil chemotaxis;GO:0030728|ovulation;GO:0030730|sequestering of triglyceride;GO:0031394|positive regulation of prostaglandin biosynthetic process;GO:0031622|positive regulation of fever generation;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0032308|positive regulation of prostaglandin secretion;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0032722|positive regulation of chemokine production;GO:0032725|positive regulation of granulocyte macrophage colony-stimulating factor production;GO:0032729|positive regulation of interferon-gamma production;GO:0032743|positive regulation of interleukin-2 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0032874|positive regulation of stress-activated MAPK cascade;GO:0033092|positive regulation of immature T cell proliferation in thymus;GO:0033198|response to ATP;GO:0033280|response to vitamin D;GO:0033591|response to L-ascorbic acid;GO:0034116|positive regulation of heterotypic cell-cell adhesion;GO:0035176|social behavior;GO:0035234|ectopic germ cell programmed cell death;GO:0035505|positive regulation of myosin light chain kinase activity;GO:0035634|response to stilbenoid;GO:0035902|response to immobilization stress;GO:0042060|wound healing;GO:0042102|positive regulation of T cell proliferation;GO:0043065|positive regulation of apoptotic process;GO:0043122|regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043278|response to morphine;GO:0043406|positive regulation of MAP kinase activity;GO:0043407|negative regulation of MAP kinase activity;GO:0043434|response to peptide hormone;GO:0043491|protein kinase B signaling;GO:0043507|positive regulation of JUN kinase activity;GO:0043525|positive regulation of neuron apoptotic process;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0045471|response to ethanol;GO:0045665|negative regulation of neuron differentiation;GO:0045687|positive regulation of glial cell differentiation;GO:0045766|positive regulation of angiogenesis;GO:0045833|negative regulation of lipid metabolic process;GO:0045840|positive regulation of mitotic nuclear division;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045917|positive regulation of complement activation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046330|positive regulation of JNK cascade;GO:0046627|negative regulation of insulin receptor signaling pathway;GO:0048143|astrocyte activation;GO:0048711|positive regulation of astrocyte differentiation;GO:0050691|regulation of defense response to virus by host;GO:0050729|positive regulation of inflammatory response;GO:0050766|positive regulation of phagocytosis;GO:0050767|regulation of neurogenesis;GO:0050768|negative regulation of neurogenesis;GO:0050796|regulation of insulin secretion;GO:0050805|negative regulation of synaptic transmission;GO:0050900|leukocyte migration;GO:0050995|negative regulation of lipid catabolic process;GO:0050996|positive regulation of lipid catabolic process;GO:0050999|regulation of nitric-oxide synthase activity;GO:0051044|positive regulation of membrane protein ectodomain proteolysis;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051384|response to glucocorticoid;GO:0051781|positive regulation of cell division;GO:0060252|positive regulation of glial cell proliferation;GO:0060559|positive regulation of calcidiol 1-monooxygenase activity;GO:0070164|negative regulation of adiponectin secretion;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070487|monocyte aggregation;GO:0070498|interleukin-1-mediated signaling pathway;GO:0070555|response to interleukin-1;GO:0071222|cellular response to lipopolysaccharide;GO:0071236|cellular response to antibiotic;GO:0071260|cellular response to mechanical stimulus;GO:0071310|cellular response to organic substance;GO:0071333|cellular response to glucose stimulus;GO:0071396|cellular response to lipid;GO:0071398|cellular response to fatty acid;GO:0071407|cellular response to organic cyclic compound;GO:0071466|cellular response to xenobiotic stimulus;GO:0071548|response to dexamethasone;GO:0071639|positive regulation of monocyte chemotactic protein-1 production;GO:0090023|positive regulation of neutrophil chemotaxis;GO:0097192|extrinsic apoptotic signaling pathway in absence of ligand;GO:1900745|positive regulation of p38MAPK cascade;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1902680|positive regulation of RNA biosynthetic process;GO:1903140|regulation of establishment of endothelial barrier;GO:1903597|negative regulation of gap junction assembly;GO:2000173|negative regulation of branching morphogenesis of a nerve;GO:2000178|negative regulation of neural precursor cell proliferation;GO:2000556|positive regulation of T-helper 1 cell cytokine production;GO:2001240|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005764|lysosome;GO:0005829|cytosol;GO:0030141|secretory granule;GO:0031982|vesicle;","GO:0005125|cytokine activity;GO:0005149|interleukin-1 receptor binding;GO:0005178|integrin binding;GO:0019904|protein domain specific binding;","K04519","IL1B; interleukin 1 beta"]
["ENSRNOG00000046452",158,13.11821236,78,5.017774178,2.614348892,1.386451685,{"v":6.52801e-13,"d":"6.53E-13"},{"v":1.6703e-12,"d":"1.67E-12"},"up","yes","Fcgr2b","protein_coding","chr13:83193163-83207778:-","gi|564381693|ref|XP_006250295.1|",1357,{"v":1E-174,"d":"1.00E-174"},"PREDICTED: low affinity immunoglobulin gamma Fc region receptor II-b isoform X1 [Rattus norvegicus]","gi|228480381|gb|AC111734.5|",2522,0,"Rattus norvegicus CH230-184H10 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q63203",456,{"v":1e-149,"d":"1.00E-149"},"Low affinity immunoglobulin gamma Fc region receptor II",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0001811|negative regulation of type I hypersensitivity;GO:0002434|immune complex clearance;GO:0002638|negative regulation of immunoglobulin production;GO:0002862|negative regulation of inflammatory response to antigenic stimulus;GO:0002865|negative regulation of acute inflammatory response to antigenic stimulus;GO:0002924|negative regulation of humoral immune response mediated by circulating immunoglobulin;GO:0006898|receptor-mediated endocytosis;GO:0006911|phagocytosis, engulfment;GO:0006952|defense response;GO:0007166|cell surface receptor signaling pathway;GO:0009617|response to bacterium;GO:0016064|immunoglobulin mediated immune response;GO:0016358|dendrite development;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0021549|cerebellum development;GO:0030889|negative regulation of B cell proliferation;GO:0032355|response to estradiol;GO:0032456|endocytic recycling;GO:0032693|negative regulation of interleukin-10 production;GO:0033030|negative regulation of neutrophil apoptotic process;GO:0038096|Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0046330|positive regulation of JNK cascade;GO:0048169|regulation of long-term neuronal synaptic plasticity;GO:0050765|negative regulation of phagocytosis;GO:0050766|positive regulation of phagocytosis;GO:0050776|regulation of immune response;GO:0050777|negative regulation of immune response;GO:0050859|negative regulation of B cell receptor signaling pathway;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0071219|cellular response to molecule of bacterial origin;GO:0071222|cellular response to lipopolysaccharide;GO:1901216|positive regulation of neuron death;GO:1902950|regulation of dendritic spine maintenance;GO:1904646|cellular response to amyloid-beta;GO:1905898|positive regulation of response to endoplasmic reticulum stress;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0043197|dendritic spine;GO:0044297|cell body;GO:0045121|membrane raft;GO:0055037|recycling endosome;","GO:0001540|amyloid-beta binding;GO:0004888|transmembrane signaling receptor activity;GO:0019772|low-affinity IgG receptor activity;GO:0019864|IgG binding;GO:0019865|immunoglobulin binding;GO:0044877|protein-containing complex binding;","K12560","FCGR2B, CD32; low affinity immunoglobulin gamma Fc receptor II-b"]
["ENSRNOG00000031598",76,6.3100262,19,1.222278326,5.162511736,2.368073156,{"v":6.77528E-13,"d":"6.78E-13"},{"v":1.7308e-12,"d":"1.73E-12"},"up","yes","Atp8b4","protein_coding","chr3:113556192-113757225:-","gi|564302296|ref|XP_006224667.1|",6228,0,"PREDICTED: probable phospholipid-transporting ATPase IM isoform X1 [Rattus norvegicus]","gi|672017295|ref|XM_006224605.2|",4416,0,"PREDICTED: Rattus norvegicus ATPase, class I, type 8B, member 4 (Atp8b4), transcript variant X1, mRNA","Q8TF62",2150,0,"Probable phospholipid-transporting ATPase IM",".",".",".",".","pfam00122","E1-E2_ATPase","E1-E2 ATPase.",".","GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0000287|magnesium ion binding;GO:0005524|ATP binding;","K01530","E7.6.2.1; phospholipid-translocating ATPase [EC:7.6.2.1]"]
["ENSRNOG00000032970",45,3.736199724,3,0.192991315,19.35941901,4.274963752,{"v":7.43728e-13,"d":"7.44E-13"},{"v":1.8931e-12,"d":"1.89E-12"},"up","yes","ENSRNOG00000032970","protein_coding","chrX:72355033-72397658:+","gi|157818411|ref|NP_001100408.1|",1778,0,"probable G-protein coupled receptor 174 [Rattus norvegicus]","gi|157818410|ref|NM_001106938.1|",4735,0,"Rattus norvegicus G protein-coupled receptor 174 (Gpr174), mRNA","Q3U507",665,0,"Probable G-protein coupled receptor 174",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0035025|positive regulation of Rho protein signal transduction;GO:0043029|T cell homeostasis;GO:0051482|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway;","GO:0005887|integral component of plasma membrane;","GO:0004930|G protein-coupled receptor activity;GO:0045125|bioactive lipid receptor activity;","K08391","GPR174; G protein-coupled receptor 174"]
["ENSRNOG00000002188",160,13.28426568,80,5.146435055,2.581255868,1.368073156,{"v":7.99711E-13,"d":"8.00E-13"},{"v":2.02756e-12,"d":"2.03E-12"},"up","yes","Hpse","protein_coding","chr14:8896593-8937010:+","gi|12018276|ref|NP_072127.1|",2627,0,"heparanase precursor [Rattus norvegicus]","gi|12018275|ref|NM_022605.1|",3134,0,"Rattus norvegicus heparanase (Hpse), mRNA","Q71RP1",1016,0,"Heparanase",".",".",".",".","pfam03662","Glyco_hydro_79n","Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesized as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumor cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity.","GO:0007160|cell-matrix adhesion;GO:0008150|biological_process;GO:0010033|response to organic substance;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0030194|positive regulation of blood coagulation;GO:0030200|heparan sulfate proteoglycan catabolic process;GO:0030202|heparin metabolic process;GO:0033690|positive regulation of osteoblast proliferation;GO:0042060|wound healing;GO:0051797|regulation of hair follicle development;GO:0051798|positive regulation of hair follicle development;GO:0051897|positive regulation of protein kinase B signaling;GO:0060055|angiogenesis involved in wound healing;GO:0061028|establishment of endothelial barrier;GO:0061042|vascular wound healing;GO:0071806|protein transmembrane transport;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005764|lysosome;GO:0005765|lysosomal membrane;GO:0031012|extracellular matrix;GO:0043231|intracellular membrane-bounded organelle;GO:0045121|membrane raft;GO:1904974|heparanase complex;","GO:0030305|heparanase activity;GO:0045545|syndecan binding;","K07964","HPSE; heparanase [EC:3.2.1.166]"]
["ENSRNOG00000015357",74,6.143972879,18,1.157947887,5.30591484,2.40760152,{"v":8.1941e-13,"d":"8.19E-13"},{"v":2.07501e-12,"d":"2.08E-12"},"up","yes","Bmper","protein_coding","chr8:21732225-21977256:+","gi|209447103|ref|NP_001129271.1|",3641,0,"BMP-binding endothelial regulator protein precursor [Rattus norvegicus]","gi|209447102|ref|NM_001135799.1|",3785,0,"Rattus norvegicus BMP-binding endothelial regulator (Bmper), mRNA","Q8CJ69",1389,0,"BMP-binding endothelial regulator protein",".",".",".",".","pfam00094","VWD","von Willebrand factor type D domain. Luciferin-2-monooxygenase from Vargula hilgendorfii contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.","GO:0001568|blood vessel development;GO:0001657|ureteric bud development;GO:0002043|blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:0010594|regulation of endothelial cell migration;GO:0030514|negative regulation of BMP signaling pathway;GO:0042118|endothelial cell activation;GO:0045765|regulation of angiogenesis;GO:0048839|inner ear development;GO:0060393|regulation of pathway-restricted SMAD protein phosphorylation;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:1903672|positive regulation of sprouting angiogenesis;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0031012|extracellular matrix;",".","K24517","BMPER; BMP-binding endothelial regulator protein"]
["ENSRNOG00000012964",47,3.902253045,4,0.257321753,15.16487822,3.922662008,{"v":8.79616e-13,"d":"8.80E-13"},{"v":2.22395E-12,"d":"2.22E-12"},"up","yes","Ccr6","protein_coding","chr1:52474168-52498603:-","gi|61557091|ref|NP_001013163.1|",1803,0,"C-C chemokine receptor type 6 [Rattus norvegicus]","gi|672034413|ref|XM_008758755.1|",2940,0,"PREDICTED: Rattus norvegicus chemokine (C-C motif) receptor 6 (Ccr6), transcript variant X1, mRNA","O54689",610,0,"C-C chemokine receptor type 6",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0002523|leukocyte migration involved in inflammatory response;GO:0006935|chemotaxis;GO:0006955|immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0010634|positive regulation of epithelial cell migration;GO:0019722|calcium-mediated signaling;GO:0048290|isotype switching to IgA isotypes;GO:0060326|cell chemotaxis;GO:0060474|positive regulation of flagellated sperm motility involved in capacitation;GO:0070098|chemokine-mediated signaling pathway;GO:0072676|lymphocyte migration;GO:0072678|T cell migration;GO:0072679|thymocyte migration;GO:1904155|DN2 thymocyte differentiation;GO:1904156|DN3 thymocyte differentiation;GO:2000404|regulation of T cell migration;GO:2000510|positive regulation of dendritic cell chemotaxis;","GO:0005575|cellular_component;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0036126|sperm flagellum;GO:0097225|sperm midpiece;GO:0097228|sperm principal piece;GO:0097524|sperm plasma membrane;","GO:0003674|molecular_function;GO:0016493|C-C chemokine receptor activity;GO:0019957|C-C chemokine binding;","K04181","CCR6, CD196; C-C chemokine receptor type 6"]
["ENSRNOG00000014163",103,8.551746034,37,2.380226213,3.592829113,1.845120318,{"v":9.72053E-13,"d":"9.72E-13"},{"v":2.45184e-12,"d":"2.45E-12"},"up","yes","Zfp536","protein_coding","chr1:90002858-90462990:-","gi|755519636|ref|XP_011248882.1|",6712,0,"PREDICTED: zinc finger protein 536 isoform X2 [Mus musculus]","gi|672013436|ref|XM_008774507.1|",4210,0,"PREDICTED: Rattus norvegicus zinc finger protein 536 (Zfp536), transcript variant X4, mRNA","Q8K083",2424,0,"Zinc finger protein 536",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006355|regulation of transcription, DNA-templated;GO:0045665|negative regulation of neuron differentiation;GO:0048387|negative regulation of retinoic acid receptor signaling pathway;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0044323|retinoic acid-responsive element binding;",".","."]
["ENSRNOG00000032368",42,3.487119742,2,0.128660876,27.10318661,4.760390579,{"v":1.31933E-12,"d":"1.32E-12"},{"v":3.30822e-12,"d":"3.31E-12"},"up","yes","Tlr11","protein_coding","chr15:23545408-23549849:+","gi|408684405|ref|NP_001138251.2|",4104,0,"toll-like receptor 11 [Rattus norvegicus]","gi|408684404|ref|NM_001144779.2|",3219,0,"Rattus norvegicus toll-like receptor 11 (Tlr11), mRNA","Q6R5P0",1326,0,"Toll-like receptor 11","alr0124_1",63.2,3E-9,"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0002224|toll-like receptor signaling pathway;GO:0006954|inflammatory response;GO:0009617|response to bacterium;GO:0045087|innate immune response;","GO:0005887|integral component of plasma membrane;","GO:0003953|NAD+ nucleosidase activity;GO:0004888|transmembrane signaling receptor activity;GO:0038023|signaling receptor activity;","K14142","TLR11; toll-like receptor 11"]
["ENSRNOG00000016041",110,9.132932658,43,2.766208842,3.301606343,1.723168115,{"v":2.02706E-12,"d":"2.03E-12"},{"v":5.02121e-12,"d":"5.02E-12"},"up","yes","Zc3h12d","protein_coding","chr1:2314324-2348819:+","gi|157818857|ref|NP_001100939.1|",2636,0,"probable ribonuclease ZC3H12D [Rattus norvegicus]","gi|157818856|ref|NM_001107469.1|",3691,0,"Rattus norvegicus zinc finger CCCH type containing 12D (Zc3h12d), mRNA","Q8BIY3",858,0,"Probable ribonuclease ZC3H12D",".",".",".",".","pfam11977","RNase_Zc3h12a","Zc3h12a-like Ribonuclease NYN domain. This domain is found in the Zc3h12a protein which has shown to be a ribonuclease that controls the stability of a set of inflammatory genes. It has been suggested that this domain belongs to the PIN domain superfamily. This domain has also been identified as part of the NYN domain family.","GO:0006402|mRNA catabolic process;GO:0030308|negative regulation of cell growth;GO:0042130|negative regulation of T cell proliferation;GO:0061158|3'-UTR-mediated mRNA destabilization;GO:0090502|RNA phosphodiester bond hydrolysis, endonucleolytic;GO:2000134|negative regulation of G1/S transition of mitotic cell cycle;","GO:0000932|P-body;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0036464|cytoplasmic ribonucleoprotein granule;","GO:0003729|mRNA binding;GO:0004521|endoribonuclease activity;GO:0046872|metal ion binding;","K18668","ZC3H12, MCPIP; ribonuclease ZC3H12 [EC:3.1.-.-]"]
["ENSRNOG00000025597",50,4.151333026,6,0.385982629,10.75523278,3.426966845,{"v":2.23779e-12,"d":"2.24E-12"},{"v":5.53099e-12,"d":"5.53E-12"},"up","yes","Rnase6","protein_coding","chr15:24354303-24357328:+","gi|573014606|tpe|CDG32035.1|",723,{"v":4E-90,"d":"4.00E-90"},"TPA: ribonuclease A d1 [Rattus norvegicus]","gi|672089524|ref|XM_008773788.1|",1393,0,"PREDICTED: Rattus norvegicus ribonuclease K6-like (LOC103694852), transcript variant X2, mRNA","Q9D244",230,{"v":1e-71,"d":"1.00E-71"},"Ribonuclease K6",".",".",".",".","pfam00074","RnaseA","Pancreatic ribonuclease. Ribonucleases. Members include pancreatic RNAase A and angiogenins. Structure is an alpha+beta fold -- long curved beta sheet and three helices.","GO:0008150|biological_process;GO:0019731|antibacterial humoral response;GO:0045087|innate immune response;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:0051607|defense response to virus;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0090501|RNA phosphodiester bond hydrolysis;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0031410|cytoplasmic vesicle;","GO:0003674|molecular_function;GO:0003676|nucleic acid binding;GO:0004519|endonuclease activity;GO:0004540|ribonuclease activity;","K01172","RNASE6_7_8; ribonuclease 6/7/8 [EC:3.1.27.-]"]
["ENSRNOG00000025805",41,3.404093082,2,0.128660876,26.45787265,4.725625161,{"v":2.59302e-12,"d":"2.59E-12"},{"v":6.38429e-12,"d":"6.38E-12"},"up","yes","Ms4a14","protein_coding","chr1:207949426-207964937:-","gi|149062445|gb|EDM12868.1|",5128,0,"rCG47812, isoform CRA_a [Rattus norvegicus]","gi|31342056|ref|NM_181082.2|",3764,0,"Rattus norvegicus membrane spanning 4-domains A14 (Ms4a14), mRNA","Q96JA4",282,{"v":4e-80,"d":"4.00E-80"},"Membrane-spanning 4-domains subfamily A member 14",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.",".","GO:0016021|integral component of membrane;",".","K22192","MS4A14; membrane-spanning 4-domains subfamily A member 14"]
["ENSRNOG00000007896",43,3.570146403,3,0.192991315,18.49900039,4.20937541,{"v":2.92413E-12,"d":"2.92E-12"},{"v":7.14724e-12,"d":"7.15E-12"},"up","yes","Klhl38","protein_coding","chr7:89855148-89864276:-","gi|148697356|gb|EDL29303.1|",3176,0,"RIKEN cDNA 8230402K04, partial [Mus musculus]","gi|68163454|ref|NM_001025008.1|",2641,0,"Rattus norvegicus kelch-like family member 38 (Klhl38), mRNA","Q5BK60",1216,0,"Kelch-like protein 38",".",".",".",".","pfam07707","BACK","BTB And C-terminal Kelch. This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).",".",".",".","K13959","KLHL38; kelch-like protein 38"]
["ENSRNOG00000006319",92,7.638452768,31,1.994243584,3.830250643,1.937438802,{"v":3.22192e-12,"d":"3.22E-12"},{"v":7.85409e-12,"d":"7.85E-12"},"up","yes","Cxcr6","protein_coding","chr8:123416325-123439526:+","gi|149018110|gb|EDL76751.1|",1844,0,"rCG26104 [Rattus norvegicus]","gi|156564360|ref|NM_001102587.1|",1055,0,"Rattus norvegicus chemokine (C-X-C motif) receptor 6 (Cxcr6), mRNA","Q9EQ16",621,0,"C-X-C chemokine receptor type 6",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0019722|calcium-mediated signaling;GO:0060326|cell chemotaxis;GO:0070098|chemokine-mediated signaling pathway;","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0015026|coreceptor activity;GO:0016493|C-C chemokine receptor activity;GO:0016494|C-X-C chemokine receptor activity;GO:0019957|C-C chemokine binding;GO:0019958|C-X-C chemokine binding;","K04191","CXCR6, CD186; C-X-C chemokine receptor type 6"]
["ENSRNOG00000010716",143,11.87281246,69,4.438800235,2.674779631,1.419420036,{"v":3.35581E-12,"d":"3.36E-12"},{"v":8.17735e-12,"d":"8.18E-12"},"up","yes","Atoh8","protein_coding","chr4:104259992-104292168:-","gi|157823435|ref|NP_001102711.1|",1253,{"v":2e-163,"d":"2.00E-163"},"protein atonal homolog 8 [Rattus norvegicus]","gi|157823434|ref|NM_001109241.1|",2375,0,"Rattus norvegicus atonal bHLH transcription factor 8 (Atoh8), mRNA","Q99NA2",457,{"v":2e-153,"d":"2.00E-153"},"Protein atonal homolog 8",".",".",".",".","pfam00010","HLH","Helix-loop-helix DNA-binding domain.","GO:0001704|formation of primary germ layer;GO:0001937|negative regulation of endothelial cell proliferation;GO:0006357|regulation of transcription by RNA polymerase II;GO:0010595|positive regulation of endothelial cell migration;GO:0010629|negative regulation of gene expression;GO:0030182|neuron differentiation;GO:0035148|tube formation;GO:0045603|positive regulation of endothelial cell differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0051450|myoblast proliferation;GO:0060395|SMAD protein signal transduction;GO:1902895|positive regulation of pri-miRNA transcription by RNA polymerase II;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0046983|protein dimerization activity;GO:0070888|E-box binding;","K09084","ATOH8; atonal protein 8"]
["ENSRNOG00000016950",160,13.28426568,83,5.339426369,2.487957463,1.31496182,{"v":3.73573e-12,"d":"3.74E-12"},{"v":9.06858e-12,"d":"9.07E-12"},"up","yes","Otud1","protein_coding","chr17:82259840-82262995:+","gi|293354776|ref|XP_574086.3|",1479,0,"PREDICTED: OTU domain-containing protein 1 isoform X2 [Rattus norvegicus]","gi|672082584|ref|XM_574086.6|",2924,0,"PREDICTED: Rattus norvegicus OTU deubiquitinase 1 (Otud1), transcript variant X2, mRNA","Q9CUB6",530,{"v":2E-176,"d":"2.00E-176"},"OTU domain-containing protein 1",".",".",".",".","pfam02338","OTU","OTU-like cysteine protease. This family is comprised of a group of predicted cysteine proteases, homologous to the Ovarian tumor (OTU) gene in Drosophila. Members include proteins from eukaryotes, viruses and pathogenic bacterium. The conserved cysteine and histidine, and possibly the aspartate, represent the catalytic residues in this putative group of proteases.","GO:0016579|protein deubiquitination;GO:0070536|protein K63-linked deubiquitination;",".","GO:0004843|thiol-dependent ubiquitin-specific protease activity;","K13716","OTUD1; OTU domain-containing protein 1 [EC:3.4.19.12]"]
["ENSRNOG00000029179",68,5.645812916,16,1.029287011,5.485168719,2.455535997,{"v":3.91344e-12,"d":"3.91E-12"},{"v":9.48557e-12,"d":"9.49E-12"},"up","yes","Cyp2d3","protein_coding","chr7:113908947-113922084:-","gi|23463315|ref|NP_695225.1|",1979,0,"cytochrome P450 2D1 [Rattus norvegicus]","gi|298911525|emb|FQ219613.1|",1277,0,"Rattus norvegicus TL0ABA44YB23 mRNA sequence","P10633",763,0,"Cytochrome P450 2D1",".",".",".",".","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0001889|liver development;GO:0006082|organic acid metabolic process;GO:0006805|xenobiotic metabolic process;GO:0009410|response to xenobiotic stimulus;GO:0010033|response to organic substance;GO:0014070|response to organic cyclic compound;GO:0019369|arachidonic acid metabolic process;GO:0042178|xenobiotic catabolic process;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0004497|monooxygenase activity;GO:0005506|iron ion binding;GO:0008395|steroid hydroxylase activity;GO:0016712|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0020037|heme binding;GO:0070330|aromatase activity;","K07414","CYP2D; cytochrome P450 family 2 subfamily D [EC:1.14.14.1]"]
["ENSRNOG00000025354",73,6.060946218,19,1.222278326,4.958728378,2.309970202,{"v":3.99299e-12,"d":"3.99E-12"},{"v":9.67473e-12,"d":"9.67E-12"},"up","yes","Rinl","protein_coding","chr1:84077265-84088330:+","gi|564327101|ref|XP_006228716.1|",2681,0,"PREDICTED: ras and Rab interactor-like protein isoform X2 [Rattus norvegicus]","gi|157819766|ref|NM_001106241.1|",2990,0,"Rattus norvegicus Ras and Rab interactor-like (Rinl), mRNA","Q80UW3",846,0,"Ras and Rab interactor-like protein",".",".",".",".","pfam02204","VPS9","Vacuolar sorting protein 9 (VPS9) domain. This domain acts as a GDP-GTP exchange factor (GEF). It activates Rab GTPases by stimulating the release of GDP and allowing GTP to bind.","GO:0006897|endocytosis;GO:0050790|regulation of catalytic activity;","GO:0001726|ruffle;GO:0015629|actin cytoskeleton;","GO:0005085|guanyl-nucleotide exchange factor activity;",".","."]
["ENSRNOG00000042229",142,11.78978579,69,4.438800235,2.656074879,1.409295819,{"v":5.19358e-12,"d":"5.19E-12"},{"v":1.25078E-11,"d":"1.25E-11"},"up","yes","Gimap1","protein_coding","chr4:77682171-77691866:+","gi|77680743|emb|CAG17876.1|",1577,0,"Ian2 protein [Rattus norvegicus]","gi|298906633|emb|FQ225168.1|",1154,0,"Rattus norvegicus TL0AEA54YO15 mRNA sequence","P70224",465,{"v":2e-154,"d":"2.00E-154"},"GTPase IMAP family member 1",".",".",".",".","pfam04548","AIG1","AIG1 family. Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.","GO:0030183|B cell differentiation;GO:0030217|T cell differentiation;","GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;","GO:0005525|GTP binding;",".","."]
["ENSRNOG00000052199",216,17.93375867,132,8.49161784,2.111936619,1.078566539,{"v":5.30008e-12,"d":"5.30E-12"},{"v":1.27547E-11,"d":"1.28E-11"},"up","yes","Zcwpw1","protein_coding","chr12:18880633-18910711:-","gi|392332566|ref|XP_003752622.1|",2959,0,"PREDICTED: zinc finger CW-type PWWP domain protein 1-like isoform X1 [Rattus norvegicus]","gi|672026628|ref|XM_003752574.3|",2268,0,"PREDICTED: Rattus norvegicus zinc finger CW-type PWWP domain protein 1-like (LOC100910636), transcript variant X1, mRNA","Q6IR42",948,0,"Zinc finger CW-type PWWP domain protein 1",".",".",".",".","pfam00855","PWWP","PWWP domain. The PWWP domain is named after a conserved Pro-Trp-Trp-Pro motif. The domain binds to Histone-4 methylated at lysine-20, H4K20me, suggesting that it is methyl-lysine recognition motif. Removal of two conserved aromatic residues in a hydrophobic cavity created by this domain within the full-length protein, Pdp1, abolishes the interaction o f the protein with H4K20me3. In fission yeast, Set9 is the sole enzyme that catalyses all three states of H4K20me, and Set9-mediated H4K20me is required for efficient recruitment of checkpoint protein Crb2 to sites of DNA damage. The methylation of H4K20 is involved in a diverse array of cellular processes, such as organizing higher-order chromatin, maintaining genome stability, and regulating cell-cycle progression.","GO:0007127|meiosis I;GO:0007129|synapsis;GO:0007283|spermatogenesis;GO:0045911|positive regulation of DNA recombination;GO:2000781|positive regulation of double-strand break repair;","GO:0001741|XY body;GO:0005634|nucleus;","GO:0008270|zinc ion binding;GO:0008327|methyl-CpG binding;GO:0035064|methylated histone binding;","K24688","ZCWPW1; zinc finger CW-type PWWP domain protein 1"]
["ENSRNOG00000054576",64,5.313706274,14,0.900626135,5.900013412,2.560718234,{"v":5.40005e-12,"d":"5.40E-12"},{"v":1.29855E-11,"d":"1.30E-11"},"up","yes","Gsdmc","protein_coding","chr7:95594015-95611344:-","gi|564360024|ref|XP_006241693.1|",2497,0,"PREDICTED: gasdermin-C isoform X1 [Rattus norvegicus]","gi|672059184|ref|XM_006241631.2|",1891,0,"PREDICTED: Rattus norvegicus gasdermin C (Gsdmc), transcript variant X1, mRNA","P85967",934,0,"Gasdermin-C",".",".",".",".","pfam04598","Gasdermin","Gasdermin family. The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein","GO:0012501|programmed cell death;GO:0042742|defense response to bacterium;GO:0070269|pyroptosis;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0001786|phosphatidylserine binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0070273|phosphatidylinositol-4-phosphate binding;","K22143","GSDMC; gasdermin-C"]
["ENSRNOG00000004459",203,16.85441209,121,7.78398302,2.165268352,1.114545836,{"v":6.57392e-12,"d":"6.57E-12"},{"v":1.57314e-11,"d":"1.57E-11"},"up","yes","Sdr9c7","protein_coding","chr7:63707071-63721480:+","gi|564308558|ref|XP_006226116.1|",1670,0,"PREDICTED: short-chain dehydrogenase/reductase family 9C member 7 [Rattus norvegicus]","gi|672021766|ref|XM_006226055.2|",2551,0,"PREDICTED: Rattus norvegicus short chain dehydrogenase/reductase family 9C, member 7 (Sdr9c7), transcript variant X4, mRNA","Q8K3P0",617,0,"Short-chain dehydrogenase/reductase family 9C member 7",".",".",".",".","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.",".",".","GO:0004745|retinol dehydrogenase activity;","K24425","SDR9C7; short-chain dehydrogenase/reductase family 9C member 7 [EC:1.1.1.-]"]
["ENSRNOG00000050968",86,7.140292805,28,1.801252269,3.964071511,1.986982989,{"v":7.39237e-12,"d":"7.39E-12"},{"v":1.7624e-11,"d":"1.76E-11"},"up","yes","Ptger2","protein_coding","chr15:18217285-18228714:+","gi|13592031|ref|NP_112350.1|",1267,{"v":9E-170,"d":"9.00E-170"},"prostaglandin E2 receptor EP2 subtype [Rattus norvegicus]","gi|13592030|ref|NM_031088.1|",1323,0,"Rattus norvegicus prostaglandin E receptor 2 (subtype EP2) (Ptger2), mRNA","Q62928",492,{"v":3E-171,"d":"3.00E-171"},"Prostaglandin E2 receptor EP2 subtype",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001501|skeletal system development;GO:0006954|inflammatory response;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0032496|response to lipopolysaccharide;GO:0032570|response to progesterone;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0042127|regulation of cell proliferation;GO:0043066|negative regulation of apoptotic process;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0071380|cellular response to prostaglandin E stimulus;GO:1902219|negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress;GO:1904346|positive regulation of gastric mucosal blood circulation;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004957|prostaglandin E receptor activity;","K04259","PTGER2; prostaglandin E receptor 2"]
["ENSRNOG00000005370",56,4.649492989,10,0.643304382,7.22751643,2.853499983,{"v":8.42005e-12,"d":"8.42E-12"},{"v":2.00144e-11,"d":"2.00E-11"},"up","yes","S1pr4","protein_coding","chr7:8208098-8211893:+","gi|157823827|ref|NP_001101545.1|",1752,0,"sphingosine 1-phosphate receptor 4 [Rattus norvegicus]","gi|157823826|ref|NM_001108075.1|",1270,0,"Rattus norvegicus sphingosine-1-phosphate receptor 4 (S1pr4), mRNA","Q9Z0L1",591,0,"Sphingosine 1-phosphate receptor 4",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0003376|sphingosine-1-phosphate receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0019222|regulation of metabolic process;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0038036|sphingosine-1-phosphate receptor activity;","K04293","S1PR4, EDG6; sphingosine 1-phosphate receptor 4"]
["ENSRNOG00000011548",123,10.21227924,55,3.5381741,2.88631338,1.529227948,{"v":8.78262e-12,"d":"8.78E-12"},{"v":2.08529e-11,"d":"2.09E-11"},"up","yes","Ebf2","protein_coding","chr15:41435509-41634403:+","gi|157821659|ref|NP_001101853.1|",2781,0,"transcription factor COE2 [Rattus norvegicus]","gi|157821658|ref|NM_001108383.1|",5439,0,"Rattus norvegicus early B-cell factor 2 (Ebf2), mRNA","Q08DL5",1074,0,"Transcription factor COE2",".",".",".",".","pfam01833","TIG","IPT/TIG domain. This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.","GO:0001709|cell fate determination;GO:0006357|regulation of transcription by RNA polymerase II;GO:0035563|positive regulation of chromatin binding;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050873|brown fat cell differentiation;GO:0060612|adipose tissue development;GO:0120162|positive regulation of cold-induced thermogenesis;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0046872|metal ion binding;","K09103","EBF, COE; early B-cell factor"]
["ENSRNOG00000021056",137,11.37465249,66,4.24580892,2.679030711,1.42171112,{"v":8.93921e-12,"d":"8.94E-12"},{"v":2.12011E-11,"d":"2.12E-11"},"up","yes","Kcnj14","protein_coding","chr1:96293435-96495459:-","gi|24962814|ref|NP_733836.1|",2050,0,"ATP-sensitive inward rectifier potassium channel 14 [Rattus norvegicus]","gi|24962813|ref|NM_170718.1|",2736,0,"Rattus norvegicus potassium voltage-gated channel subfamily J member 14 (Kcnj14), mRNA","O70596",775,0,"ATP-sensitive inward rectifier potassium channel 14",".",".",".",".","pfam01007","IRK","Inward rectifier potassium channel.","GO:0034765|regulation of ion transmembrane transport;GO:1990573|potassium ion import across plasma membrane;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0043025|neuronal cell body;","GO:0005242|inward rectifier potassium channel activity;","K05007","KCNJ14, KIR2.4; potassium inwardly-rectifying channel subfamily J member 14"]
["ENSRNOG00000019270",165,13.69939899,89,5.725408998,2.392737181,1.258661939,{"v":9.1864e-12,"d":"9.19E-12"},{"v":2.17632E-11,"d":"2.18E-11"},"up","yes","P2ry6","protein_coding","chr1:155295111-155330808:-","gi|16923974|ref|NP_476465.1|",1481,0,"P2Y purinoceptor 6 [Rattus norvegicus]","gi|48675856|ref|NM_057124.2|",2465,0,"Rattus norvegicus pyrimidinergic receptor P2Y6 (P2ry6), mRNA","Q63371",575,0,"P2Y purinoceptor 6",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0006909|phagocytosis;GO:0007186|G protein-coupled receptor signaling pathway;GO:0014911|positive regulation of smooth muscle cell migration;GO:0030321|transepithelial chloride transport;GO:0031587|positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity;GO:0032962|positive regulation of inositol trisphosphate biosynthetic process;GO:0035589|G protein-coupled purinergic nucleotide receptor signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071380|cellular response to prostaglandin E stimulus;GO:0071407|cellular response to organic cyclic compound;GO:0071415|cellular response to purine-containing compound;GO:1904707|positive regulation of vascular smooth muscle cell proliferation;GO:1905835|cellular response to pyrimidine ribonucleotide;","GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;","GO:0001621|ADP receptor activity;GO:0045029|UDP-activated nucleotide receptor activity;GO:0045030|UTP-activated nucleotide receptor activity;","K04272","P2RY6; P2Y purinoceptor 6"]
["ENSRNOG00000066026",63,5.230679613,14,0.900626135,5.807825703,2.537998158,{"v":9.99196e-12,"d":"9.99E-12"},{"v":2.36453e-11,"d":"2.36E-11"},"up","yes","ENSRNOG00000066026","lncRNA","chr9:86275635-86287059:+","gi|564369387|ref|XP_006245404.1|",191,{"v":9e-14,"d":"9.00E-14"},"PREDICTED: nuclear autoantigen Sp-100 isoform X2 [Rattus norvegicus]","gi|672024228|ref|XM_008758065.1|",516,0,"PREDICTED: Rattus norvegicus nuclear antigen Sp100-like (LOC100366216), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam09523","DUF2390","Protein of unknown function (DUF2390). Members of this family are bacterial hypothetical proteins, about 160 amino acids in length, found in various proteobacteria, including members of the genera Pseudomonas and Vibrio. The C-terminal region is poorly conserved and is not included in the model.",".",".",".",".","."]
["ENSRNOG00000001427",160,13.28426568,85,5.468087246,2.429417287,1.280610315,{"v":1.00524e-11,"d":"1.01E-11"},{"v":2.37709e-11,"d":"2.38E-11"},"up","yes","Orai2","protein_coding","chr12:20497317-20520428:+","gi|281371452|ref|NP_001163874.1|",1564,0,"protein orai-2 [Rattus norvegicus]","gi|281371451|ref|NM_001170403.1|",4047,0,"Rattus norvegicus ORAI calcium release-activated calcium modulator 2 (Orai2), mRNA","Q8BH10",515,{"v":6e-166,"d":"6.00E-166"},"Protein orai-2",".",".",".",".","pfam07856","Orai-1","Mediator of CRAC channel activity. ORAI-1 is a protein homologue of Drosophila Orai and human Orai1, Orai2 and Orai3. ORAI-1 GFP reporters are co- expressed with STIM-1 (ER CA(2+) sensors) in the gonad and intestine. The protein has four predicted transmembrane domains with a highly conserved region between TM2 ad TM3. This conserved domain is thought to function in channel regulation. ORAI1- related proteins are required for the production of the calcium channel, CRAC, along with STIM1-related proteins.","GO:0002115|store-operated calcium entry;GO:0008150|biological_process;GO:0070588|calcium ion transmembrane transport;","GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030426|growth cone;","GO:0003674|molecular_function;GO:0015279|store-operated calcium channel activity;","K16057","ORAI2; calcium release-activated calcium channel protein 2"]
["ENSRNOG00000020980",38,3.1550131,0,0.032165219,98.08772298,6.61600067,{"v":1.06366E-11,"d":"1.06E-11"},{"v":2.50965e-11,"d":"2.51E-11"},"up","yes","AABR07006278.1","protein_coding","chr1:208368386-208386814:+","gi|157821819|ref|NP_001099809.1|",711,{"v":6e-91,"d":"6.00E-91"},"membrane-spanning 4-domains, subfamily A, member 4C [Rattus norvegicus]","gi|298894680|emb|FQ227673.1|",515,0,"Rattus norvegicus TL0AEA12YF23 mRNA sequence","Q99N05",241,{"v":1e-77,"d":"1.00E-77"},"Membrane-spanning 4-domains subfamily A member 4D",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000051600",38,3.1550131,0,0.032165219,98.08772298,6.61600067,{"v":1.06366E-11,"d":"1.06E-11"},{"v":2.50965e-11,"d":"2.51E-11"},"up","yes","Ly49i4","protein_coding","chr4:164122072-164341692:-","gi|57222302|ref|NP_001009487.1|",1414,0,"Ly49 stimulatory receptor 4 [Rattus norvegicus]","gi|57222301|ref|NM_001009487.1|",1260,0,"Rattus norvegicus Ly49 stimulatory receptor 4 (Ly49s4), mRNA","Q60652",281,{"v":9e-90,"d":"9.00E-90"},"Killer cell lectin-like receptor 5",".",".",".",".","pfam08391","Ly49","Ly49-like protein, N-terminal region. The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).","GO:0009968|negative regulation of signal transduction;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;","GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0005515|protein binding;GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000010497",101,8.385692713,39,2.508887089,3.342395419,1.74088242,{"v":1.14346e-11,"d":"1.14E-11"},{"v":2.68802e-11,"d":"2.69E-11"},"up","yes","RGD1305807","protein_coding","chr5:60107085-60147539:+","gi|70608181|ref|NP_001020447.1|",2983,0,"uncharacterized protein LOC298077 [Rattus norvegicus]","gi|70608180|ref|NM_001025276.1|",2424,0,"Rattus norvegicus hypothetical LOC298077 (RGD1305807), mRNA","Q9DBN1",1070,0,"Stimulated by retinoic acid gene 6 protein-like",".",".",".",".","pfam14752","RBP_receptor","Retinol binding protein receptor. Proteins in this family function as retinol binding protein receptors.","GO:0034633|retinol transport;GO:0071939|vitamin A import;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;",".","K23088","STRA6; vitamin A receptor/transporter (stra6) family protein"]
["ENSRNOG00000027808",76,6.3100262,22,1.41526964,4.458532863,2.156569051,{"v":1.1489E-11,"d":"1.15E-11"},{"v":2.69882E-11,"d":"2.70E-11"},"up","yes","Lilra5","protein_coding","chr1:69973292-70001718:-","gi|672035221|ref|XP_008757210.1|",1426,0,"PREDICTED: leukocyte immunoglobulin-like receptor subfamily A member 5 isoform X1 [Rattus norvegicus]","gi|672035220|ref|XM_008758988.1|",1169,0,"PREDICTED: Rattus norvegicus leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 (Lilra5), transcript variant X1, mRNA","A6NI73",257,{"v":1E-78,"d":"1.00E-78"},"Leukocyte immunoglobulin-like receptor subfamily A member 5",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0019221|cytokine-mediated signaling pathway;GO:0032695|negative regulation of interleukin-12 production;GO:0032696|negative regulation of interleukin-13 production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032733|positive regulation of interleukin-10 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0043410|positive regulation of MAPK cascade;GO:0050729|positive regulation of inflammatory response;GO:0050867|positive regulation of cell activation;GO:0051928|positive regulation of calcium ion transport;GO:0061098|positive regulation of protein tyrosine kinase activity;","GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0032396|inhibitory MHC class I receptor activity;","K06512","LILR, CD85; leukocyte immunoglobulin-like receptor"]
["ENSRNOG00000063449",41,3.404093082,3,0.192991315,17.63858176,4.14066266,{"v":1.15224E-11,"d":"1.15E-11"},{"v":2.70566E-11,"d":"2.71E-11"},"up","yes","ENSRNOG00000063449","lncRNA","chr7:110021779-110033215:+","gi|149062508|gb|EDM12931.1|",205,{"v":3e-27,"d":"3.00E-27"},"ciliary neurotrophic factor, isoform CRA_d [Rattus norvegicus]","gi|672060355|ref|XR_593644.1|",1737,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102547102 (LOC102547102), transcript variant X5, ncRNA",".",".",".",".",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.",".",".",".",".","."]
["ENSRNOG00000000704",162,13.45031901,87,5.596748122,2.403238222,1.264979663,{"v":1.17774E-11,"d":"1.18E-11"},{"v":2.75946e-11,"d":"2.76E-11"},"up","yes","Cmklr1","protein_coding","chr12:42974410-43028129:+","gi|83035131|ref|NP_071554.2|",1782,0,"chemokine-like receptor 1 [Rattus norvegicus]","gi|672073389|ref|XM_006249505.2|",5932,0,"PREDICTED: Rattus norvegicus chemokine-like receptor 1 (Cmklr1), transcript variant X1, mRNA","O35786",659,0,"Chemokine-like receptor 1",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0002430|complement receptor mediated signaling pathway;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0010759|positive regulation of macrophage chemotaxis;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0032695|negative regulation of interleukin-12 production;GO:0045600|positive regulation of fat cell differentiation;GO:0050848|regulation of calcium-mediated signaling;GO:0120162|positive regulation of cold-induced thermogenesis;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0001637|G protein-coupled chemoattractant receptor activity;GO:0004875|complement receptor activity;GO:0004930|G protein-coupled receptor activity;GO:0097003|adipokinetic hormone receptor activity;GO:0097004|adipokinetic hormone binding;","K04245","CMKLR1; chemokine-like receptor 1"]
["ENSRNOG00000026702",218,18.09981199,136,8.748939593,2.068800659,1.04879464,{"v":1.26364e-11,"d":"1.26E-11"},{"v":2.95641e-11,"d":"2.96E-11"},"up","yes","Jaml","protein_coding","chr8:45383495-45416565:+","gi|392341956|ref|XP_001067982.3|",1660,0,"PREDICTED: junctional adhesion molecule-like isoform X1 [Rattus norvegicus]","gi|672061707|ref|XM_236198.8|",1484,0,"PREDICTED: Rattus norvegicus adhesion molecule, interacts with CXADR antigen 1 (Amica1), transcript variant X1, mRNA","Q80UL9",484,{"v":1E-161,"d":"1.00E-161"},"Junctional adhesion molecule-like",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0030593|neutrophil chemotaxis;GO:0035696|monocyte extravasation;GO:0046629|gamma-delta T cell activation;GO:0060054|positive regulation of epithelial cell proliferation involved in wound healing;GO:0072672|neutrophil extravasation;","GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0005923|bicellular tight junction;GO:0016021|integral component of membrane;","GO:0005178|integrin binding;GO:0042803|protein homodimerization activity;GO:0050839|cell adhesion molecule binding;",".","."]
["ENSRNOG00000051619",205,17.02046541,125,8.041304773,2.116629812,1.081768971,{"v":1.63268e-11,"d":"1.63E-11"},{"v":3.79207E-11,"d":"3.79E-11"},"up","yes","Asb2","protein_coding","chr6:122474756-122510854:-","gi|58865544|ref|NP_001011984.1|",3259,0,"ankyrin repeat and SOCS box protein 2 [Rattus norvegicus]","gi|58865543|ref|NM_001011984.1|",2483,0,"Rattus norvegicus ankyrin repeat and SOCS box-containing 2 (Asb2), mRNA","Q5U2S6",1259,0,"Ankyrin repeat and SOCS box protein 2","all2748",119,{"v":7e-28,"d":"7.00E-28"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0000209|protein polyubiquitination;GO:0001947|heart looping;GO:0006511|ubiquitin-dependent protein catabolic process;GO:0014732|skeletal muscle atrophy;GO:0016567|protein ubiquitination;GO:0031532|actin cytoskeleton reorganization;GO:0035556|intracellular signal transduction;GO:0035914|skeletal muscle cell differentiation;GO:0036336|dendritic cell migration;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045445|myoblast differentiation;GO:0055007|cardiac muscle cell differentiation;GO:0055013|cardiac muscle cell development;GO:0071800|podosome assembly;","GO:0000151|ubiquitin ligase complex;GO:0030018|Z disc;GO:0031466|Cul5-RING ubiquitin ligase complex;","GO:0061630|ubiquitin protein ligase activity;GO:0097602|cullin family protein binding;","K10324","ASB2; ankyrin repeat and SOCS box protein 2"]
["ENSRNOG00000005575",228,18.9300786,146,9.392243975,2.015501157,1.011138611,{"v":1.8002E-11,"d":"1.80E-11"},{"v":4.16601e-11,"d":"4.17E-11"},"up","yes","Abi3","protein_coding","chr10:80769822-80780816:-","gi|61557012|ref|NP_001013136.1|",1032,{"v":2E-132,"d":"2.00E-132"},"ABI gene family member 3 [Rattus norvegicus]","gi|61557011|ref|NM_001013118.1|",1683,0,"Rattus norvegicus ABI family, member 3 (Abi3), mRNA","Q8BYZ1",386,{"v":7E-128,"d":"7.00E-128"},"ABI gene family member 3",".",".",".",".","pfam07815","Abi_HHR","Abl-interactor HHR. The region featured in this family is found towards the N-terminus of a number of adaptor proteins that interact with Abl-family tyrosine kinases. More specifically, it is termed the homeo-domain homologous region (HHR), as it is similar to the DNA-binding region of homeo-domain proteins. Other homeo-domain proteins have been implicated in specifying positional information during embryonic development, and in the regulation of the expression of cell-type specific genes. The Abl-interactor proteins are thought to coordinate the cytoplasmic and nuclear functions of the Abl-family kinases, and seem to be involved in cytoskeletal reorganisation, but their precise role remains unclear.","GO:0002357|defense response to tumor cell;GO:0010593|negative regulation of lamellipodium assembly;GO:0030334|regulation of cell migration;GO:1903077|negative regulation of protein localization to plasma membrane;GO:2000774|positive regulation of cellular senescence;","GO:0005622|intracellular;GO:0005737|cytoplasm;GO:0030027|lamellipodium;GO:0031209|SCAR complex;","GO:0017124|SH3 domain binding;GO:0042802|identical protein binding;","K23710","ABI3; abi gene family member 3"]
["ENSRNOG00000070434",67,5.562786255,17,1.093617449,5.086592446,2.346699505,{"v":1.95887E-11,"d":"1.96E-11"},{"v":4.51685e-11,"d":"4.52E-11"},"up","yes","ENSRNOG00000070434","protein_coding","chr2:193412971-193420030:-","gi|564300827|ref|XP_006224300.1|",584,{"v":3e-70,"d":"3.00E-70"},"PREDICTED: transmembrane protein C1orf162 homolog [Rattus norvegicus]","gi|672016201|ref|XM_006224238.2|",1031,0,"PREDICTED: Rattus norvegicus hypothetical LOC100363228 (LOC100363228), mRNA","Q3U7U4",137,{"v":5e-37,"d":"5.00E-37"},"Transmembrane protein C1orf162 homolog",".",".",".",".","pfam00852","Glyco_transf_10","Glycosyltransferase family 10 (fucosyltransferase). This family of Fucosyltransferases are the enzymes transferring fucose from GDP-Fucose to GlcNAc in an alpha1,3 linkage. This family is know as glycosyltransferase family 10.",".",".",".",".","."]
["ENSRNOG00000016535",40,3.321066421,3,0.192991315,17.20837245,4.10503875,{"v":2.28899e-11,"d":"2.29E-11"},{"v":5.25908e-11,"d":"5.26E-11"},"up","yes","Ccl22","lncRNA","chr19:10257601-10264400:-","gi|149032436|gb|EDL87327.1|",875,{"v":7e-111,"d":"7.00E-111"},"chemokine (C-C motif) ligand 22 [Rattus norvegicus]","gi|57528025|ref|NM_057203.1|",1742,0,"Rattus norvegicus chemokine (C-C motif) ligand 22 (Ccl22), mRNA","O88430",152,{"v":2e-42,"d":"2.00E-42"},"C-C motif chemokine 22",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0002548|monocyte chemotaxis;GO:0006954|inflammatory response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0008150|biological_process;GO:0030593|neutrophil chemotaxis;GO:0031640|killing of cells of other organism;GO:0043547|positive regulation of GTPase activity;GO:0048247|lymphocyte chemotaxis;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098|chemokine-mediated signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;","GO:0005575|cellular_component;GO:0005615|extracellular space;","GO:0003674|molecular_function;GO:0008009|chemokine activity;GO:0048020|CCR chemokine receptor binding;","K21095","CCL22; C-C motif chemokine 22"]
["ENSRNOG00000004861",58,4.81554631,12,0.771965258,6.238035014,2.641091651,{"v":2.45749E-11,"d":"2.46E-11"},{"v":5.63206e-11,"d":"5.63E-11"},"up","yes","Itga4","protein_coding","chr3:64163085-64233715:+","gi|157819949|ref|NP_001101207.1|",5493,0,"integrin alpha-4 [Rattus norvegicus]","gi|157819948|ref|NM_001107737.1|",3733,0,"Rattus norvegicus integrin subunit alpha 4 (Itga4), mRNA","Q00651",1978,0,"Integrin alpha-4",".",".",".",".","pfam08441","Integrin_alpha2","Integrin alpha. This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.","GO:0001974|blood vessel remodeling;GO:0002687|positive regulation of leukocyte migration;GO:0003366|cell-matrix adhesion involved in ameboidal cell migration;GO:0007155|cell adhesion;GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007159|leukocyte cell-cell adhesion;GO:0007160|cell-matrix adhesion;GO:0007229|integrin-mediated signaling pathway;GO:0007507|heart development;GO:0016477|cell migration;GO:0033631|cell-cell adhesion mediated by integrin;GO:0034113|heterotypic cell-cell adhesion;GO:0034446|substrate adhesion-dependent cell spreading;GO:0035987|endodermal cell differentiation;GO:0043113|receptor clustering;GO:0050901|leukocyte tethering or rolling;GO:0050904|diapedesis;GO:0060324|face development;GO:0060385|axonogenesis involved in innervation;GO:0060710|chorio-allantoic fusion;GO:0071345|cellular response to cytokine stimulus;GO:0072678|T cell migration;GO:0090074|negative regulation of protein homodimerization activity;GO:0098657|import into cell;GO:0140039|cell-cell adhesion in response to extracellular stimulus;GO:1903039|positive regulation of leukocyte cell-cell adhesion;GO:1903238|positive regulation of leukocyte tethering or rolling;GO:1904646|cellular response to amyloid-beta;GO:1905564|positive regulation of vascular endothelial cell proliferation;GO:1990138|neuron projection extension;GO:1990771|clathrin-dependent extracellular exosome endocytosis;GO:2000353|positive regulation of endothelial cell apoptotic process;GO:2000406|positive regulation of T cell migration;","GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0030426|growth cone;GO:0034669|integrin alpha4-beta7 complex;GO:0043025|neuronal cell body;GO:0070062|extracellular exosome;","GO:0001968|fibronectin binding;GO:0003823|antigen binding;GO:0005515|protein binding;GO:0019960|C-X3-C chemokine binding;GO:0050839|cell adhesion molecule binding;GO:1990405|protein antigen binding;","K06483","ITGA4, CD49d; integrin alpha 4"]
["ENSRNOG00000070619",114,9.4650393,50,3.216521909,2.942631689,1.557106981,{"v":2.77086E-11,"d":"2.77E-11"},{"v":6.32755E-11,"d":"6.33E-11"},"up","yes","ENSRNOG00000070619","lncRNA","chr7:15903881-15929311:-","gi|672058315|ref|XP_008763488.1|",413,{"v":1E-42,"d":"1.00E-42"},"PREDICTED: inactive phospholipase C-like protein 2 [Rattus norvegicus]","gi|672058313|ref|XR_593304.1|",2178,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102552467 (LOC102552467), transcript variant X3, ncRNA",".",".",".",".",".",".",".",".","pfam04822","Takusan","Takusan. This domain is named takusan, which is a Japanese word meaning 'many'. Members of this family regulate synaptic activity.",".",".",".",".","."]
["ENSRNOG00000013317",209,17.35257205,130,8.362956964,2.074932602,1.053064475,{"v":2.86135E-11,"d":"2.86E-11"},{"v":6.52954e-11,"d":"6.53E-11"},"up","yes","RGD1565222","protein_coding","chr15:28037574-28064274:-","gi|157819271|ref|NP_001102571.1|",2505,0,"uncharacterized protein C14orf93 homolog [Rattus norvegicus]","gi|157819270|ref|NM_001109101.1|",2653,0,"Rattus norvegicus similar to RIKEN cDNA 4931414P19 (RGD1565222), mRNA","Q8K2W9",949,0,"Uncharacterized protein C14orf93 homolog",".",".",".",".","pfam15394","DUF4616","Domain of unknown function (DUF4616). This protein family is a domain of unknown function found at the C-terminal domain of the proteins. This protein family is found in eukaryotes. Proteins in this family are typically between 166 and 538 amino acids in length.","GO:0010628|positive regulation of gene expression;GO:0030154|cell differentiation;GO:0048856|anatomical structure development;",".",".",".","."]
["ENSRNOG00000020585",115,9.54806596,51,3.280852347,2.910239459,1.541137865,{"v":3.19788e-11,"d":"3.20E-11"},{"v":7.2819e-11,"d":"7.28E-11"},"up","yes","Tbxa2r","protein_coding","chr7:8383378-8388176:-","gi|564357987|ref|XP_006240908.1|",1475,0,"PREDICTED: thromboxane A2 receptor isoform X1 [Rattus norvegicus]","gi|8394421|ref|NM_017054.1|",1820,0,"Rattus norvegicus thromboxane A2 receptor (Tbxa2r), mRNA","P34978",572,0,"Thromboxane A2 receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0006954|inflammatory response;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007584|response to nutrient;GO:0009410|response to xenobiotic stimulus;GO:0019229|regulation of vasoconstriction;GO:0019932|second-messenger-mediated signaling;GO:0030104|water homeostasis;GO:0030194|positive regulation of blood coagulation;GO:0032496|response to lipopolysaccharide;GO:0033574|response to testosterone;GO:0038193|thromboxane A2 signaling pathway;GO:0045471|response to ethanol;GO:0045766|positive regulation of angiogenesis;GO:0045777|positive regulation of blood pressure;GO:0045907|positive regulation of vasoconstriction;GO:0045987|positive regulation of smooth muscle contraction;GO:0071222|cellular response to lipopolysaccharide;GO:0090051|negative regulation of cell migration involved in sprouting angiogenesis;","GO:0001669|acrosomal vesicle;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0016607|nuclear speck;","GO:0004960|thromboxane receptor activity;GO:0004961|thromboxane A2 receptor activity;GO:0005515|protein binding;","K04264","TBXA2R; thromboxane A2 receptor"]
["ENSRNOG00000059519",48,3.985279705,7,0.450313067,8.850020119,3.145680735,{"v":3.40627e-11,"d":"3.41E-11"},{"v":7.73988e-11,"d":"7.74E-11"},"up","yes","Bbox1","protein_coding","chr3:96822655-96871458:-","gi|12018320|ref|NP_072151.1|",2098,0,"gamma-butyrobetaine dioxygenase [Rattus norvegicus]","gi|298881757|emb|FQ210746.1|",2607,0,"Rattus norvegicus TL0ABA23YC02 mRNA sequence","Q9QZU7",812,0,"Gamma-butyrobetaine dioxygenase","mll1440",185,{"v":1E-50,"d":"1.00E-50"},"COG2175","pfam02668","TauD","Taurine catabolism dioxygenase TauD, TfdA family. This family consists of taurine catabolism dioxygenases of the TauD, TfdA family. TauD from Escherichia coli is an alpha-ketoglutarate-dependent taurine dioxygenase. This enzyme catalyses the oxygenolytic release of sulfite from taurine. TfdA from Burkholderia sp. is a 2,4-dichlorophenoxyacetic acid/alpha-ketoglutarate dioxygenase.  TfdA from Alcaligenes eutrophus JMP134 is a 2,4-dichlorophenoxyacetate monooxygenase. Also included are gamma-Butyrobetaine hydroxylase enzymes EC:1.14.11.1.","GO:0045329|carnitine biosynthetic process;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;","GO:0005506|iron ion binding;GO:0008270|zinc ion binding;GO:0008336|gamma-butyrobetaine dioxygenase activity;GO:0042802|identical protein binding;","K00471","BBOX1; gamma-butyrobetaine dioxygenase [EC:1.14.11.1]"]
["ENSRNOG00000014039",36,2.988959779,0,0.032165219,92.92521124,6.537998158,{"v":3.41924e-11,"d":"3.42E-11"},{"v":7.76659E-11,"d":"7.77E-11"},"up","yes","Sucnr1","protein_coding","chr2:144219122-144230034:+","gi|48040447|ref|NP_001001518.1|",1661,0,"succinate receptor 1 [Rattus norvegicus]","gi|48040446|ref|NM_001001518.1|",954,0,"Rattus norvegicus succinate receptor 1 (Sucnr1), mRNA","Q6IYF9",644,0,"Succinate receptor 1",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0002001|renin secretion into blood stream;GO:0002281|macrophage activation involved in immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0042593|glucose homeostasis;GO:0050729|positive regulation of inflammatory response;GO:0050921|positive regulation of chemotaxis;GO:0051592|response to calcium ion;GO:0060177|regulation of angiotensin metabolic process;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0038023|signaling receptor activity;","K10042","SUCNR1, GPR91; succinate receptor 1"]
["ENSRNOG00000011284",125,10.37833257,59,3.795495853,2.734381216,1.451214391,{"v":3.63373e-11,"d":"3.63E-11"},{"v":8.23041e-11,"d":"8.23E-11"},"up","yes","Sgms2","protein_coding","chr2:219893572-219967546:-","gi|62078817|ref|NP_001014065.1|",1764,0,"phosphatidylcholine:ceramide cholinephosphotransferase 2 [Rattus norvegicus]","gi|672044215|ref|XM_006233311.2|",1662,0,"PREDICTED: Rattus norvegicus sphingomyelin synthase 2 (Sgms2), transcript variant X2, mRNA","Q4JM44",682,0,"Phosphatidylcholine:ceramide cholinephosphotransferase 2",".",".",".",".","pfam14360","PAP2_C","PAP2 superfamily C-terminal. This family is closely related to the C-terminal a region of PAP2.","GO:0006686|sphingomyelin biosynthetic process;GO:0016310|phosphorylation;GO:0030500|regulation of bone mineralization;GO:0046513|ceramide biosynthetic process;GO:1905373|ceramide phosphoethanolamine biosynthetic process;","GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0030173|integral component of Golgi membrane;GO:0030176|integral component of endoplasmic reticulum membrane;","GO:0002950|ceramide phosphoethanolamine synthase activity;GO:0016301|kinase activity;GO:0033188|sphingomyelin synthase activity;GO:0047493|ceramide cholinephosphotransferase activity;","K04714","SGMS; shingomyelin synthase [EC:2.7.8.27]"]
["ENSRNOG00000009730",100,8.302666052,40,2.573217527,3.226569835,1.690001251,{"v":3.73636e-11,"d":"3.74E-11"},{"v":8.4509e-11,"d":"8.45E-11"},"up","yes","Cyp7b1","protein_coding","chr2:100502791-100669698:-","gi|149048513|gb|EDM01054.1|",2391,0,"cytochrome P450, family 7, subfamily b, polypeptide 1 [Rattus norvegicus]","gi|158186666|ref|NM_019138.1|",2614,0,"Rattus norvegicus cytochrome P450, family 7, subfamily b, polypeptide 1 (Cyp7b1), mRNA","Q63688",786,0,"25-hydroxycholesterol 7-alpha-hydroxylase (Fragment)","YHR007c",82.4,{"v":2e-15,"d":"2.00E-15"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0006699|bile acid biosynthetic process;GO:0007613|memory;GO:0007623|circadian rhythm;GO:0008203|cholesterol metabolic process;GO:0009410|response to xenobiotic stimulus;GO:0033147|negative regulation of intracellular estrogen receptor signaling pathway;GO:0035754|B cell chemotaxis;GO:0042632|cholesterol homeostasis;GO:0050679|positive regulation of epithelial cell proliferation;GO:0051591|response to cAMP;GO:0060740|prostate gland epithelium morphogenesis;","GO:0005575|cellular_component;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0004497|monooxygenase activity;GO:0005506|iron ion binding;GO:0008395|steroid hydroxylase activity;GO:0008396|oxysterol 7-alpha-hydroxylase activity;GO:0016705|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0020037|heme binding;GO:0033783|25-hydroxycholesterol 7alpha-hydroxylase activity;GO:0047092|27-hydroxycholesterol 7-alpha-monooxygenase activity;","K07430","CYP7B; 25/26-hydroxycholesterol 7alpha-hydroxylase [EC:1.14.14.29]"]
["ENSRNOG00000043203",37,3.071986439,2,0.128660876,23.87661678,4.577526522,{"v":3.919e-11,"d":"3.92E-11"},{"v":8.84209e-11,"d":"8.84E-11"},"up","yes","Krt75","protein_coding","chr7:132688237-132697345:-","gi|148672089|gb|EDL04036.1|",2007,0,"keratin 75, partial [Mus musculus]","gi|672059945|ref|XM_006242325.2|",2159,0,"PREDICTED: Rattus norvegicus keratin 75 (Krt75), transcript variant X1, mRNA","Q6IG05",766,0,"Keratin, type II cytoskeletal 75",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0002244|hematopoietic progenitor cell differentiation;","GO:0005882|intermediate filament;GO:0045095|keratin filament;",".","K07605","KRT2; type II keratin, basic"]
["ENSRNOG00000030930",113,9.382012639,50,3.216521909,2.916819131,1.544395929,{"v":4.41673E-11,"d":"4.42E-11"},{"v":9.95453e-11,"d":"9.95E-11"},"up","yes","Samsn1","protein_coding","chr11:14483893-14534900:-","gi|830260187|ref|NP_570834.2|",1485,0,"SAM domain-containing protein SAMSN-1 [Rattus norvegicus]","gi|830260186|ref|NM_130821.2|",1201,0,"Rattus norvegicus SAM domain, SH3 domain and nuclear localization signals, 1 (Samsn1), mRNA","P57725",519,{"v":5e-179,"d":"5.00E-179"},"SAM domain-containing protein SAMSN-1",".",".",".",".","pfam12485","SLY","Lymphocyte signaling adaptor protein. This domain family is found in eukaryotes, and is typically between 144 and 156 amino acids in length. The family is found in association with pfam07647, pfam07653. There is a conserved LGKK sequence motif. SLY contains a Src homology 3 domain and a sterile alpha motif, suggesting that it functions as a signaling adaptor protein in lymphocytes.","GO:0002820|negative regulation of adaptive immune response;GO:0050732|negative regulation of peptidyl-tyrosine phosphorylation;GO:0050869|negative regulation of B cell activation;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0001784|phosphotyrosine residue binding;","K23707","SAMSN1; SAM domain-containing protein SAMSN-1"]
["ENSRNOG00000013321",222,18.43191864,143,9.19925266,2.003632177,1.002617686,{"v":4.51318e-11,"d":"4.51E-11"},{"v":1.01648E-10,"d":"1.02E-10"},"up","yes","Dock11","protein_coding","chrX:115131909-115314854:+","gi|564400486|ref|XP_006257515.1|",10972,0,"PREDICTED: dedicator of cytokinesis protein 11 isoform X1 [Rattus norvegicus]","gi|672088185|ref|XM_006257453.2|",6697,0,"PREDICTED: Rattus norvegicus dedicator of cytokinesis 11 (Dock11), transcript variant X1, mRNA","A2AF47",4139,0,"Dedicator of cytokinesis protein 11",".",".",".",".","pfam06920","Ded_cyto","Dedicator of cytokinesis. This family represents a conserved region approximately 200 residues long within a number of eukaryotic dedicator of cytokinesis proteins. These are potential guanine nucleotide exchange factors, which activate some small GTPases by exchanging bound GDP for free GTP.","GO:0001782|B cell homeostasis;GO:0002315|marginal zone B cell differentiation;GO:0007264|small GTPase mediated signal transduction;GO:0043547|positive regulation of GTPase activity;GO:0051491|positive regulation of filopodium assembly;",".","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0031267|small GTPase binding;","K21853","DOCK9_10_11; dedicator of cytokinesis protein 9/10/11"]
["ENSRNOG00000029768",149,12.37097242,79,5.082104617,2.434222306,1.283460928,{"v":4.73608e-11,"d":"4.74E-11"},{"v":1.0648E-10,"d":"1.06E-10"},"up","yes","Ccl12","protein_coding","chr10:67070230-67071780:+","gi|157786668|ref|NP_001099292.1|",454,{"v":6e-55,"d":"6.00E-55"},"chemokine (C-C motif) ligand 12 precursor [Rattus norvegicus]","gi|157786667|ref|NM_001105822.1|",540,0,"Rattus norvegicus chemokine (C-C motif) ligand 12 (Ccl12), mRNA","Q62401",154,{"v":1E-46,"d":"1.00E-46"},"C-C motif chemokine 12",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0001525|angiogenesis;GO:0002548|monocyte chemotaxis;GO:0002687|positive regulation of leukocyte migration;GO:0006468|protein phosphorylation;GO:0006816|calcium ion transport;GO:0006874|cellular calcium ion homeostasis;GO:0006887|exocytosis;GO:0006954|inflammatory response;GO:0007010|cytoskeleton organization;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007267|cell-cell signaling;GO:0008360|regulation of cell shape;GO:0030593|neutrophil chemotaxis;GO:0031640|killing of cells of other organism;GO:0043547|positive regulation of GTPase activity;GO:0044828|negative regulation by host of viral genome replication;GO:0048245|eosinophil chemotaxis;GO:0048247|lymphocyte chemotaxis;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098|chemokine-mediated signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070664|negative regulation of leukocyte proliferation;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;","GO:0005575|cellular_component;GO:0005615|extracellular space;","GO:0003674|molecular_function;GO:0004672|protein kinase activity;GO:0008009|chemokine activity;GO:0016004|phospholipase activator activity;GO:0031727|CCR2 chemokine receptor binding;GO:0048020|CCR chemokine receptor binding;","K14624","CCL2, MCP1; C-C motif chemokine 2"]
["ENSRNOG00000015297",41,3.404093082,4,0.257321753,13.22893632,3.725625161,{"v":5.3379e-11,"d":"5.34E-11"},{"v":1.19465e-10,"d":"1.19E-10"},"up","yes","RGD1561662","protein_coding","chr9:13525395-13561585:-","gi|564367294|ref|XP_006244562.1|",4149,0,"PREDICTED: uncharacterized protein C6orf132 homolog isoform X2 [Rattus norvegicus]","gi|672064477|ref|XM_006244500.2|",4071,0,"PREDICTED: Rattus norvegicus similar to AI661453 protein (RGD1561662), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam03154","Atrophin-1","Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.",".",".",".",".","."]
["ENSRNOG00000034174",41,3.404093082,4,0.257321753,13.22893632,3.725625161,{"v":5.3379e-11,"d":"5.34E-11"},{"v":1.19465e-10,"d":"1.19E-10"},"up","yes","Bpifb4","protein_coding","chr3:142400976-142448044:+","gi|306482632|ref|NP_001102679.2|",2530,0,"BPI fold-containing family B member 4 precursor [Rattus norvegicus]","gi|306482631|ref|NM_001109209.2|",1932,0,"Rattus norvegicus BPI fold containing family B, member 4 (Bpifb4), mRNA","Q05704",984,0,"BPI fold-containing family B member 4",".",".",".",".","pfam01273","LBP_BPI_CETP","LBP / BPI / CETP family, N-terminal domain. The N and C terminal domains of the LBP/BPI/CETP family are structurally similar.",".","GO:0005576|extracellular region;GO:0005737|cytoplasm;","GO:0008289|lipid binding;","K25376","BPIFB, LPLUNC; BPI fold-containing family B"]
["ENSRNOG00000013694",216,17.93375867,138,8.87760047,2.020113288,1.014436202,{"v":5.39206e-11,"d":"5.39E-11"},{"v":1.20592e-10,"d":"1.21E-10"},"up","yes","Ntng2","protein_coding","chr3:12492639-12545890:-","gi|564339989|ref|XP_006233862.1|",3261,0,"PREDICTED: netrin-G2 isoform X1 [Rattus norvegicus]","gi|672044927|ref|XM_006233800.2|",2387,0,"PREDICTED: Rattus norvegicus netrin G2 (Ntng2), transcript variant X1, mRNA","Q8R4F1",1132,0,"Netrin-G2",".",".",".",".","pfam00055","Laminin_N","Laminin N-terminal (Domain VI).","GO:0007409|axonogenesis;GO:0009887|animal organ morphogenesis;GO:0009888|tissue development;GO:0010975|regulation of neuron projection development;GO:0016477|cell migration;GO:0034446|substrate adhesion-dependent cell spreading;GO:0050804|modulation of chemical synaptic transmission;GO:0070831|basement membrane assembly;GO:0098698|postsynaptic specialization assembly;GO:0099560|synaptic membrane adhesion;GO:0150011|regulation of neuron projection arborization;GO:1905606|regulation of presynapse assembly;GO:2001222|regulation of neuron migration;","GO:0005886|plasma membrane;GO:0030424|axon;GO:0043256|laminin complex;GO:0045171|intercellular bridge;GO:0046658|anchored component of plasma membrane;GO:0090543|Flemming body;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098978|glutamatergic synapse;GO:0099029|anchored component of presynaptic active zone membrane;",".","K16359","NTNG2; netrin-G2"]
["ENSRNOG00000002906",35,2.905933118,0,0.032165219,90.34395538,6.497356173,{"v":6.15747e-11,"d":"6.16E-11"},{"v":1.37327e-10,"d":"1.37E-10"},"up","yes","Nr1i2","protein_coding","chr11:62460213-62496658:+","gi|16418481|ref|NP_443212.1|",2312,0,"nuclear receptor subfamily 1 group I member 2 [Rattus norvegicus]","gi|148536881|ref|NM_052980.2|",2335,0,"Rattus norvegicus nuclear receptor subfamily 1, group I, member 2 (Nr1i2), mRNA","Q9R1A7",895,0,"Nuclear receptor subfamily 1 group I member 2",".",".",".",".","pfam00105","zf-C4","Zinc finger, C4 type (two domains). In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006355|regulation of transcription, DNA-templated;GO:0006805|xenobiotic metabolic process;GO:0010628|positive regulation of gene expression;GO:0030154|cell differentiation;GO:0030522|intracellular receptor signaling pathway;GO:0042178|xenobiotic catabolic process;GO:0042908|xenobiotic transport;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0016604|nuclear body;GO:0045111|intermediate filament cytoskeleton;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0004879|nuclear receptor activity;GO:0008270|zinc ion binding;GO:0016922|nuclear receptor binding;GO:1990837|sequence-specific double-stranded DNA binding;","K08540","NR1I2, PXR; pregnane X receptor"]
["ENSRNOG00000069051",92,7.638452768,35,2.251565336,3.392507712,1.762352095,{"v":6.43527e-11,"d":"6.44E-11"},{"v":1.43272E-10,"d":"1.43E-10"},"up","yes","ENSRNOG00000069051","lncRNA","chr14:83415689-83420637:+","gi|149036607|gb|EDL91225.1|",144,2E-8,"rCG56442 [Rattus norvegicus]","gi|672028133|ref|XR_594132.1|",2177,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103693171 (LOC103693171), ncRNA",".",".",".",".",".",".",".",".","pfam13030","DUF3891","Protein of unknown function (DUF3891). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and archaea. Proteins in this family are approximately 250 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000062887",45,3.736199724,6,0.385982629,9.679709505,3.274963752,{"v":6.44165e-11,"d":"6.44E-11"},{"v":1.43314E-10,"d":"1.43E-10"},"up","yes","Gpr35","protein_coding","chr9:93527127-93539299:+","gi|564369848|ref|XP_006245599.1|",1513,0,"PREDICTED: G-protein coupled receptor 35 isoform X1 [Rattus norvegicus]","gi|672066184|ref|XM_006245537.2|",2936,0,"PREDICTED: Rattus norvegicus G protein-coupled receptor 35 (Gpr35), transcript variant X3, mRNA","Q9ES90",519,{"v":1E-172,"d":"1.00E-172"},"G-protein coupled receptor 35",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.",".",".",".",".","."]
["ENSRNOG00000062678",86,7.140292805,31,1.994243584,3.580451688,1.8401416,{"v":7.65994e-11,"d":"7.66E-11"},{"v":1.69711e-10,"d":"1.70E-10"},"up","yes","H19","protein_coding","chr1:197730698-197733134:-","gi|111797|pir||S15484",448,{"v":7e-59,"d":"7.00E-59"},"hypothetical protein - rat","gi|224922740|ref|NR_027324.1|",2031,0,"Rattus norvegicus H19, imprinted maternally expressed transcript (non-protein coding) (H19), long non-coding RNA",".",".",".",".",".",".",".",".","pfam15252","DUF4589","Domain of unknown function (DUF4589). This protein family is a domain of unknown function. The precise function of the protein domain remains to be elucidated. This family of proteins is found in eukaryotes and are typically between 215 and 293 amino acids in length. The protein contains two conserved sequence motifs: SSS and KST.",".",".",".",".","."]
["ENSRNOG00000055721",97,8.053586071,39,2.508887089,3.210023323,1.68258378,{"v":8.36121e-11,"d":"8.36E-11"},{"v":1.84544E-10,"d":"1.85E-10"},"up","yes","ENSRNOG00000055721","protein_coding","chrX:103183831-103298423:+","gi|148691965|gb|EDL23912.1|",2446,0,"ring finger protein 128, partial [Mus musculus]","gi|298915108|emb|FQ210020.1|",2708,0,"Rattus norvegicus TL0ABA36YD02 mRNA sequence","Q9D304",849,0,"E3 ubiquitin-protein ligase RNF128",".",".",".",".","pfam13639","zf-RING_2","Ring finger domain.","GO:0001818|negative regulation of cytokine production;GO:0006511|ubiquitin-dependent protein catabolic process;GO:0016567|protein ubiquitination;GO:0031647|regulation of protein stability;","GO:0005737|cytoplasm;GO:0005770|late endosome;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;","GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;","K10629","RNF128, GRAIL; E3 ubiquitin-protein ligase RNF128 [EC:2.3.2.27]"]
["ENSRNOG00000017120",118,9.797145942,55,3.5381741,2.768983567,1.469356492,{"v":8.56883e-11,"d":"8.57E-11"},{"v":1.89061E-10,"d":"1.89E-10"},"up","yes","Abhd2","protein_coding","chr1:133217375-133299061:+","gi|157820401|ref|NP_001099745.1|",2235,0,"abhydrolase domain-containing protein 2 [Rattus norvegicus]","gi|74137721|dbj|AK139526.1|",2014,0,"Mus musculus 2 cells egg cDNA, RIKEN full-length enriched library, clone:B020003E02 product:abhydrolase domain containing 2, full insert sequence","Q9QXM0",863,0,"Monoacylglycerol lipase ABHD2","ECU07g0900",108,{"v":3E-24,"d":"3.00E-24"},"COG0429","pfam00561","Abhydrolase_1","alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.","GO:0007340|acrosome reaction;GO:0009611|response to wounding;GO:0030336|negative regulation of cell migration;GO:0032570|response to progesterone;GO:0043401|steroid hormone mediated signaling pathway;GO:0044255|cellular lipid metabolic process;GO:0046464|acylglycerol catabolic process;GO:0048240|sperm capacitation;GO:0051792|medium-chain fatty acid biosynthetic process;GO:0051793|medium-chain fatty acid catabolic process;","GO:0001669|acrosomal vesicle;GO:0036126|sperm flagellum;GO:0097524|sperm plasma membrane;","GO:0003707|steroid hormone receptor activity;GO:0008126|acetylesterase activity;GO:0033878|hormone-sensitive lipase activity;GO:0034338|short-chain carboxylesterase activity;GO:0042562|hormone binding;GO:0047372|acylglycerol lipase activity;","K13697","ABHD2; abhydrolase domain-containing protein 2"]
["ENSRNOG00000063964",214,17.76770535,138,8.87760047,2.001408535,1.001015686,{"v":1.06187E-10,"d":"1.06E-10"},{"v":2.32843e-10,"d":"2.33E-10"},"up","yes","Jdp2","protein_coding","chr6:105261373-105301485:+","gi|672056419|ref|XP_008762956.1|",1132,{"v":2e-148,"d":"2.00E-148"},"PREDICTED: jun dimerization protein 2 isoform X2 [Rattus norvegicus]","gi|672056418|ref|XM_008764734.1|",1451,0,"PREDICTED: Rattus norvegicus Jun dimerization protein 2 (Jdp2), transcript variant X1, mRNA","Q78E65",244,{"v":6e-76,"d":"6.00E-76"},"Jun dimerization protein 2",".",".",".",".","pfam00170","bZIP_1","bZIP transcription factor. The Pfam entry includes the basic region and the leucine zipper region.",".",".",".",".","."]
["ENSRNOG00000067827",34,2.822906458,0,0.032165219,87.76269951,6.455535997,{"v":1.11223E-10,"d":"1.11E-10"},{"v":2.43635e-10,"d":"2.44E-10"},"up","yes","Ly49i3","protein_coding","chr4:164362017-164384266:-","gi|57222330|ref|NP_001009499.1|",1513,0,"immunoreceptor Ly49i3 [Rattus norvegicus]","gi|672051460|ref|XM_008763405.1|",1115,0,"PREDICTED: Rattus norvegicus Ly49 inhibitory receptor 4 (Ly49i4), transcript variant X1, mRNA","Q60652",285,{"v":1E-91,"d":"1.00E-91"},"Killer cell lectin-like receptor 5",".",".",".",".","pfam08391","Ly49","Ly49-like protein, N-terminal region. The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).",".",".",".",".","."]
["ENSRNOG00000011263",67,5.562786255,19,1.222278326,4.551161662,2.186234833,{"v":1.30544E-10,"d":"1.31E-10"},{"v":2.84691e-10,"d":"2.85E-10"},"up","yes","Plac9","protein_coding","chr16:1459456-1474399:-","gi|564387936|ref|XP_006252692.1|",256,{"v":2e-23,"d":"2.00E-23"},"PREDICTED: placenta-specific protein 9 isoform X1 [Rattus norvegicus]","gi|672079314|ref|XM_006252630.2|",344,{"v":1e-178,"d":"1.00E-178"},"PREDICTED: Rattus norvegicus placenta-specific 9 (Plac9), transcript variant X1, mRNA","Q8K262",77.8,{"v":1e-16,"d":"1.00E-16"},"Placenta-specific protein 9",".",".",".",".","pfam15205","PLAC9","Placenta-specific protein 9. This family of proteins was identified as being enriched in placenta.",".",".",".",".","."]
["ENSRNOG00000000172",150,12.45399908,82,5.275095931,2.360904757,1.239339842,{"v":1.33575E-10,"d":"1.34E-10"},{"v":2.91103e-10,"d":"2.91E-10"},"up","yes","Sqor","protein_coding","chr3:109841250-109960778:+","gi|209862751|ref|NP_001041378.2|",2329,0,"sulfide:quinone oxidoreductase, mitochondrial [Rattus norvegicus]","gi|672046990|ref|XM_006234887.2|",1402,0,"PREDICTED: Rattus norvegicus sulfide quinone reductase-like (yeast) (Sqrdl), transcript variant X1, mRNA","Q9R112",845,0,"Sulfide:quinone oxidoreductase, mitochondrial","SA0084",421,{"v":4e-140,"d":"4.00E-140"},"COG0446","pfam13738","Pyr_redox_3","Pyridine nucleotide-disulphide oxidoreductase.","GO:0070221|sulfide oxidation, using sulfide:quinone oxidoreductase;GO:0070813|hydrogen sulfide metabolic process;","GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;","GO:0070224|sulfide:quinone oxidoreductase activity;GO:0071949|FAD binding;","K22470","SQOR; eukaryotic sulfide quinone oxidoreductase [EC:1.8.5.8]"]
["ENSRNOG00000003959",62,5.147652953,16,1.029287011,5.001183244,2.322269467,{"v":1.41963e-10,"d":"1.42E-10"},{"v":3.08855e-10,"d":"3.09E-10"},"up","yes","Rgs18","protein_coding","chr13:56494010-56516098:-","gi|149058439|gb|EDM09596.1|",1249,{"v":5e-170,"d":"5.00E-170"},"regulator of G-protein signaling 18 [Rattus norvegicus]","gi|672074059|ref|XM_008769548.1|",818,0,"PREDICTED: Rattus norvegicus regulator of G-protein signaling 18 (Rgs18), transcript variant X1, mRNA","Q4L0E8",484,{"v":5e-171,"d":"5.00E-171"},"Regulator of G-protein signaling 18",".",".",".",".","pfam00615","RGS","Regulator of G protein signaling domain. RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0008277|regulation of G protein-coupled receptor signaling pathway;GO:0009968|negative regulation of signal transduction;GO:0050790|regulation of catalytic activity;","GO:0005737|cytoplasm;","GO:0005096|GTPase activator activity;","K16449","RGS; regulator of G-protein signaling"]
["ENSRNOG00000042455",35,2.905933118,2,0.128660876,22.58598884,4.497356173,{"v":1.53522e-10,"d":"1.54E-10"},{"v":3.33662e-10,"d":"3.34E-10"},"up","yes","Tlr12","protein_coding","chr5:140959996-140964816:-","gi|672054117|ref|XP_008762370.1|",3846,0,"PREDICTED: toll-like receptor 12 isoform X1 [Rattus norvegicus]","gi|672054116|ref|XM_008764148.1|",3536,0,"PREDICTED: Rattus norvegicus toll-like receptor 12 (Tlr12), transcript variant X1, mRNA","Q6QNU9",1125,0,"Toll-like receptor 12",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.","GO:0002224|toll-like receptor signaling pathway;GO:0006954|inflammatory response;GO:0045087|innate immune response;","GO:0005887|integral component of plasma membrane;","GO:0003953|NAD+ nucleosidase activity;GO:0004888|transmembrane signaling receptor activity;GO:0038023|signaling receptor activity;","K18807","TLR12; toll-like receptor 12"]
["ENSRNOG00000006723",205,17.02046541,131,8.427287402,2.019684935,1.014130254,{"v":1.67099e-10,"d":"1.67E-10"},{"v":3.62186e-10,"d":"3.62E-10"},"up","yes","Itga11","protein_coding","chr8:63146001-63254407:+","gi|672062052|ref|XP_008764500.1|",6362,0,"PREDICTED: integrin alpha-11 isoform X2 [Rattus norvegicus]","gi|672062051|ref|XM_008766278.1|",4913,0,"PREDICTED: Rattus norvegicus integrin, alpha 11 (Itga11), transcript variant X2, mRNA","P61622",2385,0,"Integrin alpha-11",".",".",".",".","pfam08441","Integrin_alpha2","Integrin alpha. This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.","GO:0006929|substrate-dependent cell migration;GO:0007160|cell-matrix adhesion;GO:0007229|integrin-mediated signaling pathway;GO:0008150|biological_process;GO:0033627|cell adhesion mediated by integrin;GO:0038065|collagen-activated signaling pathway;","GO:0005575|cellular_component;GO:0005925|focal adhesion;GO:0034681|integrin alpha11-beta1 complex;","GO:0003674|molecular_function;GO:0005518|collagen binding;GO:0038064|collagen receptor activity;GO:0046872|metal ion binding;GO:0098639|collagen binding involved in cell-matrix adhesion;","K06587","ITGA11; integrin alpha 11"]
["ENSRNOG00000056574",33,2.739879797,0,0.032165219,85.18144364,6.412467276,{"v":2.01531e-10,"d":"2.02E-10"},{"v":4.33876e-10,"d":"4.34E-10"},"up","yes","Tigit","protein_coding","chr11:57029118-57045994:+","gi|672026084|ref|XP_008774911.1|",1185,{"v":2e-162,"d":"2.00E-162"},"PREDICTED: T-cell immunoreceptor with Ig and ITIM domains isoform X1 [Rattus norvegicus]","gi|672071268|ref|XM_008768765.1|",764,0,"PREDICTED: Rattus norvegicus T cell immunoreceptor with Ig and ITIM domains (Tigit), transcript variant X1, mRNA","P86176",387,{"v":8e-135,"d":"8.00E-135"},"T-cell immunoreceptor with Ig and ITIM domains",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0032695|negative regulation of interleukin-12 production;GO:0032733|positive regulation of interleukin-10 production;GO:0050868|negative regulation of T cell activation;","GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0005102|signaling receptor binding;GO:0042802|identical protein binding;","K16350","TIGIT; T-cell immunoreceptor with Ig and ITIM domains"]
["ENSRNOG00000025925",51,4.234359687,10,0.643304382,6.582202463,2.718570403,{"v":2.04681e-10,"d":"2.05E-10"},{"v":4.40213E-10,"d":"4.40E-10"},"up","yes","Txk","protein_coding","chr14:35463944-35519448:+","gi|66730395|ref|NP_001019426.1|",2728,0,"tyrosine-protein kinase TXK [Rattus norvegicus]","gi|66730394|ref|NM_001024255.1|",2281,0,"Rattus norvegicus TXK tyrosine kinase (Txk), mRNA","P42682",958,0,"Tyrosine-protein kinase TXK",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001819|positive regulation of cytokine production;GO:0001865|NK T cell differentiation;GO:0002250|adaptive immune response;GO:0006468|protein phosphorylation;GO:0007202|activation of phospholipase C activity;GO:0007229|integrin-mediated signaling pathway;GO:0008150|biological_process;GO:0010468|regulation of gene expression;GO:0010543|regulation of platelet activation;GO:0032729|positive regulation of interferon-gamma production;GO:0038083|peptidyl-tyrosine autophosphorylation;GO:0042246|tissue regeneration;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046777|protein autophosphorylation;GO:0050852|T cell receptor signaling pathway;GO:0060335|positive regulation of interferon-gamma-mediated signaling pathway;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0003674|molecular_function;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0005524|ATP binding;","K08016","TXK, RLK; tyrosine-protein kinase TXK [EC:2.7.10.2]"]
["ENSRNOG00000016278",39,3.23803976,4,0.257321753,12.58362236,3.653475375,{"v":2.09531e-10,"d":"2.10E-10"},{"v":4.50342e-10,"d":"4.50E-10"},"up","yes","Ccl17","protein_coding","chr19:10202128-10203819:-","gi|149032433|gb|EDL87324.1|",432,{"v":1E-51,"d":"1.00E-51"},"chemokine (C-C motif) ligand 17 [Rattus norvegicus]","gi|755526535|ref|XM_011248331.1|",285,{"v":5e-146,"d":"5.00E-146"},"PREDICTED: Mus musculus chemokine (C-C motif) ligand 17 (Ccl17), transcript variant X3, mRNA","Q95N01",111,{"v":7e-30,"d":"7.00E-30"},"C-C motif chemokine 17",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0002548|monocyte chemotaxis;GO:0006954|inflammatory response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0008150|biological_process;GO:0030593|neutrophil chemotaxis;GO:0031640|killing of cells of other organism;GO:0043547|positive regulation of GTPase activity;GO:0045662|negative regulation of myoblast differentiation;GO:0048247|lymphocyte chemotaxis;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098|chemokine-mediated signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;","GO:0005575|cellular_component;GO:0005615|extracellular space;","GO:0008009|chemokine activity;GO:0031729|CCR4 chemokine receptor binding;GO:0048020|CCR chemokine receptor binding;","K21083","CCL17; C-C motif chemokine 17"]
["ENSRNOG00000003870",158,13.11821236,90,5.789739437,2.26576904,1.180000808,{"v":2.27764e-10,"d":"2.28E-10"},{"v":4.87561e-10,"d":"4.88E-10"},"up","yes","C1qtnf2","protein_coding","chr10:27941948-27959185:+","gi|300793915|ref|NP_001178847.1|",921,{"v":1E-117,"d":"1.00E-117"},"complement C1q tumor necrosis factor-related protein 2 precursor [Rattus norvegicus]","gi|672067176|ref|XM_006246141.2|",1062,0,"PREDICTED: Rattus norvegicus C1q and tumor necrosis factor related protein 2 (C1qtnf2), transcript variant X1, mRNA","Q9D8U4",357,{"v":2E-118,"d":"2.00E-118"},"Complement C1q tumor necrosis factor-related protein 2",".",".",".",".","pfam00386","C1q","C1q domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.","GO:0019216|regulation of lipid metabolic process;GO:0043410|positive regulation of MAPK cascade;GO:0045725|positive regulation of glycogen biosynthetic process;GO:0046321|positive regulation of fatty acid oxidation;GO:0046326|positive regulation of glucose import;","GO:0005615|extracellular space;GO:0032991|protein-containing complex;","GO:0005102|signaling receptor binding;GO:0042802|identical protein binding;","K24211","C1QTNF2; complement C1q and tumor necrosis factor-related protein 2"]
["ENSRNOG00000049537",193,16.02414548,121,7.78398302,2.058604886,1.041666956,{"v":2.34154E-10,"d":"2.34E-10"},{"v":5.00738e-10,"d":"5.01E-10"},"up","yes","ENSRNOG00000049537","protein_coding","chr13:72274552-72312103:+","gi|149058287|gb|EDM09444.1|",784,{"v":1e-93,"d":"1.00E-93"},"rCG46225, isoform CRA_a [Rattus norvegicus]","gi|242332507|ref|NM_001162898.1|",3854,0,"Rattus norvegicus hypothetical protein LOC100302372 (LOC100302372), mRNA",".",".",".",".",".",".",".",".","pfam03154","Atrophin-1","Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.",".",".",".",".","."]
["ENSRNOG00000024452",145,12.03886578,79,5.082104617,2.368874056,1.244201498,{"v":2.38082e-10,"d":"2.38E-10"},{"v":5.08458E-10,"d":"5.08E-10"},"up","yes","Carmil2","protein_coding","chr19:33574257-33586965:+","gi|564321375|ref|XP_006222773.1|",6207,0,"PREDICTED: leucine-rich repeat-containing protein 16C isoform X1 [Rattus norvegicus]","gi|672031241|ref|XM_006222711.2|",4534,0,"PREDICTED: Rattus norvegicus RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing (Rltpr), transcript variant X1, mRNA","Q6F5E8",1993,0,"Capping protein, Arp2/3 and myosin-I linker protein 2",".",".",".",".","pfam15279","SOBP","Sine oculis-binding protein. SOBP is associated with syndromic and nonsyndromic intellectual disability. It carries a zinc-finger of the zf-C2H2 type at the N-terminus, and a highly characteristic C-terminal PhPhPhPhPhPh motif. The deduced 873-amino acid protein contains an N-terminal nuclear localisation signal (NLS), followed by 2 FCS-type zinc finger motifs, a proline-rich region (PR1), a putative RNA-binding motif region, and a C-terminal NLS embedded in a second proline-rich motif. SOBP is expressed in various human tissues, including developing mouse brain at embryonic day 14. In postnatal and adult mouse brain SOBP is expressed in all neurons, with intense staining in the limbic system. Highest expression is in layer V cortical neurons, hippocampus, pyriform cortex, dorsomedial nucleus of thalamus, amygdala, and hypothalamus. Postnatal expression of SOBP in the limbic system corresponds to a time of active synaptogenesis. the family is also referred to as Jackson circler, JXC1. In seven affected siblings from a consanguineous Israeli Arab family with mental retardation, anterior maxillary protrusion, and strabismus mutations were found in this protein.","GO:0007163|establishment or maintenance of cell polarity;GO:0010592|positive regulation of lamellipodium assembly;GO:0030011|maintenance of cell polarity;GO:0030335|positive regulation of cell migration;GO:0032729|positive regulation of interferon-gamma production;GO:0032743|positive regulation of interleukin-2 production;GO:0042102|positive regulation of T cell proliferation;GO:0044319|wound healing, spreading of cells;GO:0045184|establishment of protein localization;GO:0045591|positive regulation of regulatory T cell differentiation;GO:0048538|thymus development;GO:0048872|homeostasis of number of cells;GO:0050852|T cell receptor signaling pathway;GO:0051639|actin filament network formation;GO:0061339|establishment or maintenance of monopolar cell polarity;GO:0090091|positive regulation of extracellular matrix disassembly;GO:1900029|positive regulation of ruffle assembly;GO:1902745|positive regulation of lamellipodium organization;GO:2000813|negative regulation of barbed-end actin filament capping;","GO:0001726|ruffle;GO:0001772|immunological synapse;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0008290|F-actin capping protein complex;GO:0015629|actin cytoskeleton;GO:0030027|lamellipodium;GO:0031252|cell leading edge;GO:0044354|macropinosome;GO:0045111|intermediate filament cytoskeleton;","GO:0005543|phospholipid binding;GO:0044877|protein-containing complex binding;","K20493","LRRC16, CARMIL; leucine-rich repeat-containing protein 16"]
["ENSRNOG00000007811",47,3.902253045,8,0.514643505,7.582439112,2.922662008,{"v":2.39558e-10,"d":"2.40E-10"},{"v":5.11268e-10,"d":"5.11E-10"},"up","yes","Klrb1c","protein_coding","chr4:162381602-162393786:+","gi|145966851|ref|NP_001078872.1|",1038,{"v":1e-140,"d":"1.00E-140"},"killer cell lectin-like receptor subfamily B member 1F [Rattus norvegicus]","gi|672051237|ref|XM_008763329.1|",738,0,"PREDICTED: Rattus norvegicus killer cell lectin-like receptor subfamily B member 1C (Klrb1c), transcript variant X1, mRNA","Q63378",404,{"v":4e-142,"d":"4.00E-142"},"Killer cell lectin-like receptor subfamily B member 1F",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type",".","GO:0016021|integral component of membrane;","GO:0030246|carbohydrate binding;","K06543","KLRB, CD161; killer cell lectin-like receptor subfamily B"]
["ENSRNOG00000051534",43,3.570146403,6,0.385982629,9.249500193,3.20937541,{"v":2.45289e-10,"d":"2.45E-10"},{"v":5.22628e-10,"d":"5.23E-10"},"up","yes","Prr33","protein_coding","chr1:197644902-197650714:-","gi|109459666|ref|XP_001064406.1|",1750,0,"PREDICTED: proline-rich protein 33 [Rattus norvegicus]","gi|672014503|ref|XM_002725732.4|",2140,0,"PREDICTED: Rattus norvegicus hypothetical protein LOC685580 (LOC685580), transcript variant X1, mRNA","Q8C494",341,{"v":4e-110,"d":"4.00E-110"},"Proline-rich protein 33",".",".",".",".","pfam15485","DUF4643","Domain of unknown function (DUF4643). This family of proteins is found in eukaryotes. Proteins in this family are typically between 254 and 462 amino acids in length.","GO:0009611|response to wounding;",".",".",".","."]
["ENSRNOG00000065043",34,2.822906458,2,0.128660876,21.94067488,4.455535997,{"v":3.04425e-10,"d":"3.04E-10"},{"v":6.45613e-10,"d":"6.46E-10"},"up","yes","RGD1562462","protein_coding","chr13:85940078-85951004:-","gi|76827550|gb|AAI07379.1|",476,{"v":7e-56,"d":"7.00E-56"},"Pyhin1 protein [Mus musculus]","gi|672027390|ref|XR_339906.2|",676,0,"PREDICTED: Rattus norvegicus similar to Ifi204 protein (RGD1562462), misc_RNA","Q8BV49",187,{"v":1E-54,"d":"1.00E-54"},"Pyrin and HIN domain-containing protein 1",".",".",".",".","pfam02758","PYRIN","PAAD/DAPIN/Pyrin domain. This domain is predicted to contain 6 alpha helices and to have the same fold as the pfam00531 domain. This similarity may mean that this is a protein-protein interaction domain.",".",".",".",".","."]
["ENSRNOG00000030763",52,4.317386347,11,0.70763482,6.101150233,2.609081256,{"v":3.40157e-10,"d":"3.40E-10"},{"v":7.18058e-10,"d":"7.18E-10"},"up","yes","Dpp4","protein_coding","chr3:46962243-47043901:-","gi|149022111|gb|EDL79005.1|",3673,0,"dipeptidylpeptidase 4, isoform CRA_a [Rattus norvegicus]","gi|6978772|ref|NM_012789.1|",4361,0,"Rattus norvegicus dipeptidylpeptidase 4 (Dpp4), mRNA","P14740",1410,0,"Dipeptidyl peptidase 4","SPACUNK4.08",306,{"v":1e-86,"d":"1.00E-86"},"COG1506","pfam00930","DPPIV_N","Dipeptidyl peptidase IV (DPP IV) N-terminal region. This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.","GO:0001662|behavioral fear response;GO:0001666|response to hypoxia;GO:0002337|B-1a B cell differentiation;GO:0002709|regulation of T cell mediated immunity;GO:0002717|positive regulation of natural killer cell mediated immunity;GO:0006508|proteolysis;GO:0007155|cell adhesion;GO:0008284|positive regulation of cell proliferation;GO:0010716|negative regulation of extracellular matrix disassembly;GO:0031295|T cell costimulation;GO:0033632|regulation of cell-cell adhesion mediated by integrin;GO:0035641|locomotory exploration behavior;GO:0036343|psychomotor behavior;GO:0042110|T cell activation;GO:0043542|endothelial cell migration;GO:0046718|viral entry into host cell;GO:0050919|negative chemotaxis;GO:0051234|establishment of localization;GO:0090024|negative regulation of neutrophil chemotaxis;","GO:0005576|extracellular region;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0030027|lamellipodium;GO:0030054|cell junction;GO:0030139|endocytic vesicle;GO:0031258|lamellipodium membrane;GO:0045121|membrane raft;GO:0046581|intercellular canaliculus;","GO:0001618|virus receptor activity;GO:0002020|protease binding;GO:0004177|aminopeptidase activity;GO:0004252|serine-type endopeptidase activity;GO:0005102|signaling receptor binding;GO:0005518|collagen binding;GO:0008236|serine-type peptidase activity;GO:0008239|dipeptidyl-peptidase activity;GO:0042277|peptide binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0045499|chemorepellent activity;","K01278","DPP4, CD26; dipeptidyl-peptidase 4 [EC:3.4.14.5]"]
["ENSRNOG00000021499",32,2.656853137,0,0.032165219,82.60018777,6.368073156,{"v":3.66339e-10,"d":"3.66E-10"},{"v":7.71799e-10,"d":"7.72E-10"},"up","yes","Siglech","protein_coding","chr1:106593721-106598022:+","gi|293344093|ref|XP_001054672.2|",1677,0,"PREDICTED: myeloid cell surface antigen CD33 isoform X1 [Rattus norvegicus]","gi|298908737|emb|FQ232259.1|",1011,0,"Rattus norvegicus TL0AEA66YH10 mRNA sequence","P20138",250,{"v":2E-78,"d":"2.00E-78"},"Myeloid cell surface antigen CD33",".",".",".",".","pfam08205","C2-set_2","CD80-like C2-set immunoglobulin domain. These domains belong to the immunoglobulin superfamily.","GO:0007155|cell adhesion;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0033691|sialic acid binding;","K06473","CD33, SIGLEC3; CD33 antigen"]
["ENSRNOG00000052940",32,2.656853137,0,0.032165219,82.60018777,6.368073156,{"v":3.66339e-10,"d":"3.66E-10"},{"v":7.71799e-10,"d":"7.72E-10"},"up","yes","AABR07030791.1","protein_coding","chr10:100056504-100078190:-","gi|564313998|ref|XP_006221095.1|",1115,{"v":6e-150,"d":"6.00E-150"},"PREDICTED: CMRF35-like molecule 5 isoform X1 [Rattus norvegicus]","gi|672025726|ref|XM_006221033.2|",738,0,"PREDICTED: Rattus norvegicus similar to MAIR-IIb (RGD1562156), transcript variant X1, mRNA","Q8VCH2",233,{"v":9e-73,"d":"9.00E-73"},"CMRF35-like molecule 5",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000050509",134,11.12557251,71,4.567461111,2.435833002,1.284415227,{"v":4.30169e-10,"d":"4.30E-10"},{"v":9.00931e-10,"d":"9.01E-10"},"up","yes","Ebi3","protein_coding","chr9:783617-787544:+","gi|157821551|ref|NP_001102891.1|",1124,{"v":4e-151,"d":"4.00E-151"},"interleukin-27 subunit beta precursor [Rattus norvegicus]","gi|157821550|ref|NM_001109421.1|",1162,0,"Rattus norvegicus Epstein-Barr virus induced 3 (Ebi3), mRNA","O35228",378,{"v":2e-129,"d":"2.00E-129"},"Interleukin-27 subunit beta",".",".",".",".","pfam09294","Interfer-bind","Interferon-alpha/beta receptor, fibronectin type III. Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.","GO:0019221|cytokine-mediated signaling pathway;GO:0033210|leptin-mediated signaling pathway;GO:0042098|T cell proliferation;","GO:0009897|external side of plasma membrane;GO:0043235|receptor complex;","GO:0004896|cytokine receptor activity;GO:0017046|peptide hormone binding;GO:0019955|cytokine binding;GO:0045523|interleukin-27 receptor binding;","K24476","EBI3, IL27B; interleukin 27 subunit beta"]
["ENSRNOG00000024793",68,5.645812916,21,1.350939202,4.179176167,2.063218575,{"v":4.32941e-10,"d":"4.33E-10"},{"v":9.06144e-10,"d":"9.06E-10"},"up","yes","Kctd21","protein_coding","chr1:151650104-151667645:+","gi|625217933|ref|XP_007649206.1|",1426,0,"PREDICTED: BTB/POZ domain-containing protein KCTD21 [Cricetulus griseus]","gi|672038043|ref|XM_006229781.2|",3029,0,"PREDICTED: Rattus norvegicus potassium channel tetramerization domain containing 21 (Kctd21), transcript variant X1, mRNA","Q4G0X4",534,0,"BTB/POZ domain-containing protein KCTD21",".",".",".",".","pfam02214","BTB_2","BTB/POZ domain. In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.",".",".",".",".","."]
["ENSRNOG00000020997",46,3.819226384,8,0.514643505,7.42111062,2.891635112,{"v":4.5838e-10,"d":"4.58E-10"},{"v":9.58132e-10,"d":"9.58E-10"},"up","yes","Ms4a4c","protein_coding","chr1:208124986-208146351:+","gi|157821819|ref|NP_001099809.1|",1120,{"v":2E-150,"d":"2.00E-150"},"membrane-spanning 4-domains, subfamily A, member 4C [Rattus norvegicus]","gi|672039830|ref|XM_006231087.2|",1150,0,"PREDICTED: Rattus norvegicus membrane-spanning 4-domains, subfamily A, member 4C (Ms4a4c), transcript variant X1, mRNA","Q99N05",299,{"v":2e-98,"d":"2.00E-98"},"Membrane-spanning 4-domains subfamily A member 4D",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.",".","GO:0016021|integral component of membrane;",".","K22190","MS4A3S; membrane-spanning 4-domains subfamily A member 3/4/8/12/15/18"]
["ENSRNOG00000062297",63,5.230679613,18,1.157947887,4.517197769,2.175428078,{"v":5.21263e-10,"d":"5.21E-10"},{"v":1.08532e-09,"d":"1.09E-09"},"up","yes","Klra5","protein_coding","chr4:164806003-164823382:-","gi|672051289|ref|XP_008761566.1|",1346,0,"PREDICTED: killer cell lectin-like receptor, subfamily A, member 5 isoform X3 [Rattus norvegicus]","gi|38454231|ref|NM_198746.1|",1128,0,"Rattus norvegicus killer cell lectin-like receptor, subfamily A, member 5 (Klra5), mRNA","Q60652",322,{"v":6e-107,"d":"6.00E-107"},"Killer cell lectin-like receptor 5",".",".",".",".","pfam08391","Ly49","Ly49-like protein, N-terminal region. The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).","GO:0030101|natural killer cell activation;","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000005082",69,5.728839576,22,1.41526964,4.04787852,2.017165994,{"v":5.78046e-10,"d":"5.78E-10"},{"v":1.20003E-9,"d":"1.20E-09"},"up","yes","Irf6","protein_coding","chr13:104672179-104691386:+","gi|1685128|gb|AAB36714.1|",2302,0,"interferon regulatory factor 6 [Mus musculus]","gi|157819782|ref|NM_001108859.1|",4044,0,"Rattus norvegicus interferon regulatory factor 6 (Irf6), mRNA","P97431",887,0,"Interferon regulatory factor 6",".",".",".",".","pfam10401","IRF-3","Interferon-regulatory factor 3. This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1).  Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.","GO:0002376|immune system process;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008150|biological_process;GO:0008285|negative regulation of cell proliferation;GO:0030216|keratinocyte differentiation;GO:0043588|skin development;GO:0043616|keratinocyte proliferation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048468|cell development;GO:0051726|regulation of cell cycle;GO:0060021|roof of mouth development;GO:0060173|limb development;GO:0060644|mammary gland epithelial cell differentiation;GO:1904888|cranial skeletal system development;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0030054|cell junction;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K10154","IRF6; interferon regulatory factor 6"]
["ENSRNOG00000003170",79,6.559106181,29,1.865582707,3.51584851,1.813872909,{"v":6.58699E-10,"d":"6.59E-10"},{"v":1.36216E-9,"d":"1.36E-09"},"up","yes","Nlrp3","protein_coding","chr10:44328566-44352811:+","gi|300798702|ref|NP_001178571.1|",5138,0,"NACHT, LRR and PYD domains-containing protein 3 [Rattus norvegicus]","gi|300798701|ref|NM_001191642.1|",3857,0,"Rattus norvegicus NLR family, pyrin domain containing 3 (Nlrp3), mRNA","D4A523",1982,0,"NACHT, LRR and PYD domains-containing protein 3",".",".",".",".","pfam05729","NACHT","NACHT domain. This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.","GO:0002523|leukocyte migration involved in inflammatory response;GO:0002526|acute inflammatory response;GO:0002674|negative regulation of acute inflammatory response;GO:0002720|positive regulation of cytokine production involved in immune response;GO:0002830|positive regulation of type 2 immune response;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006954|inflammatory response;GO:0014070|response to organic cyclic compound;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0032691|negative regulation of interleukin-1 beta production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032736|positive regulation of interleukin-13 production;GO:0032753|positive regulation of interleukin-4 production;GO:0032754|positive regulation of interleukin-5 production;GO:0043280|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0044546|NLRP3 inflammasome complex assembly;GO:0045087|innate immune response;GO:0045471|response to ethanol;GO:0045630|positive regulation of T-helper 2 cell differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050727|regulation of inflammatory response;GO:0050728|negative regulation of inflammatory response;GO:0050830|defense response to Gram-positive bacterium;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051607|defense response to virus;GO:0071222|cellular response to lipopolysaccharide;GO:0071224|cellular response to peptidoglycan;GO:1901223|negative regulation of NIK/NF-kappaB signaling;GO:2000321|positive regulation of T-helper 17 cell differentiation;GO:2000553|positive regulation of T-helper 2 cell cytokine production;","GO:0000139|Golgi membrane;GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0061702|inflammasome complex;GO:0072559|NLRP3 inflammasome complex;","GO:0003674|molecular_function;GO:0005524|ATP binding;GO:0042802|identical protein binding;GO:0043565|sequence-specific DNA binding;","K12800","NLRP3, PYPAF1; NACHT, LRR and PYD domains-containing protein 3"]
["ENSRNOG00000007301",176,14.61269225,109,7.012017762,2.083949692,1.05932045,{"v":8.49909e-10,"d":"8.50E-10"},{"v":1.73901E-9,"d":"1.74E-09"},"up","yes","Gdf9","protein_coding","chr10:37595679-37599672:+","gi|4867837|emb|CAA57488.1|",2358,0,"growth/differentiation factor-9 [Rattus norvegicus]","gi|11067392|ref|NM_021672.1|",1382,0,"Rattus norvegicus growth differentiation factor 9 (Gdf9), mRNA","Q07105",835,0,"Growth/differentiation factor 9",".",".",".",".","pfam00019","TGF_beta","Transforming growth factor beta like domain.","GO:0001550|ovarian cumulus expansion;GO:0001555|oocyte growth;GO:0001824|blastocyst development;GO:0008284|positive regulation of cell proliferation;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0030308|negative regulation of cell growth;GO:0030509|BMP signaling pathway;GO:0040016|embryonic cleavage;GO:0043406|positive regulation of MAP kinase activity;GO:0045737|positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0060395|SMAD protein signal transduction;GO:1900195|positive regulation of oocyte maturation;GO:2000870|regulation of progesterone secretion;","GO:0005615|extracellular space;GO:0005737|cytoplasm;","GO:0005125|cytokine activity;GO:0008083|growth factor activity;GO:0070698|type I activin receptor binding;","K22673","GDF9; growth differentiation factor 9"]
["ENSRNOG00000070606",39,3.23803976,5,0.321652191,10.06689788,3.33154728,{"v":8.97147e-10,"d":"8.97E-10"},{"v":1.83039e-09,"d":"1.83E-09"},"up","yes","ENSRNOG00000070606","protein_coding","chr4:70001317-70014600:+","gi|228120|prf||1717324K",659,{"v":1e-75,"d":"1.00E-75"},"T cell receptor variable region:SUBUNIT=beta:ISOTYPE=8.1","gi|3192972|gb|AF044279.1|AF044279",824,0,"Rattus norvegicus strain Sprague-Dawley T cell receptor beta chain 5.2 (TCRBV5S2) gene, TCRBV5S2*1 allele, partial cds",".",".",".",".",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000014387",57,4.73251965,15,0.964956573,4.904386149,2.294072575,{"v":1.02928E-9,"d":"1.03E-09"},{"v":2.08931e-09,"d":"2.09E-09"},"up","yes","Chac1","protein_coding","chr3:106342302-106345526:+","gi|958753309|ref|XP_014712856.1|",1130,{"v":4e-148,"d":"4.00E-148"},"PREDICTED: LOW QUALITY PROTEIN: glutathione-specific gamma-glutamylcyclotransferase 1 [Equus asinus]","gi|290746390|ref|NM_001173437.1|",1566,0,"Rattus norvegicus ChaC glutathione-specific gamma-glutamylcyclotransferase 1 (Chac1), mRNA","B3STU3",407,{"v":6e-139,"d":"6.00E-139"},"Glutathione-specific gamma-glutamylcyclotransferase 1","SPBC31F10.03",99.8,{"v":7e-23,"d":"7.00E-23"},"COG3703","pfam04752","ChaC","ChaC-like protein. The ChaC protein is thought to be associated with the putative ChaA Ca2+/H+ cation transport protein in Escherichia coli. Its function is not known. This family also includes homologues regions from several other bacterial and eukaryotic proteins.","GO:0006751|glutathione catabolic process;GO:0006986|response to unfolded protein;GO:0007219|Notch signaling pathway;GO:0010955|negative regulation of protein processing;GO:0022008|neurogenesis;GO:0045746|negative regulation of Notch signaling pathway;GO:0070059|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;","GO:0005737|cytoplasm;GO:0005802|trans-Golgi network;GO:0005829|cytosol;","GO:0003839|gamma-glutamylcyclotransferase activity;GO:0005112|Notch binding;GO:0061928|glutathione specific gamma-glutamylcyclotransferase activity;","K07232","CHAC, chaC; glutathione-specific gamma-glutamylcyclotransferase [EC:4.3.2.7]"]
["ENSRNOG00000030253",57,4.73251965,15,0.964956573,4.904386149,2.294072575,{"v":1.02928E-9,"d":"1.03E-09"},{"v":2.08931e-09,"d":"2.09E-09"},"up","yes","Tafa3","protein_coding","chr2:192267093-192274019:-","gi|564300804|ref|XP_006224296.1|",679,{"v":1e-81,"d":"1.00E-81"},"PREDICTED: protein FAM19A3 [Rattus norvegicus]","gi|672016182|ref|XM_006224235.2|",2176,0,"PREDICTED: Rattus norvegicus family with sequence similarity 19 (chemokine (C-C motif)-like), member A3 (Fam19a3), transcript variant X2, mRNA","Q7TPG6",246,{"v":8e-76,"d":"8.00E-76"},"Protein FAM19A3",".",".",".",".","pfam12020","TAFA","TAFA family. This family of secreted proteins are brain specific and thought to be chemokines. These proteins are found in vertebrates. Proteins in this family are typically between 94 to 133 amino acids in length and contain a number of conserved cysteines.","GO:0007165|signal transduction;GO:0014016|neuroblast differentiation;GO:1902692|regulation of neuroblast proliferation;GO:1903979|negative regulation of microglial cell activation;GO:1903980|positive regulation of microglial cell activation;","GO:0005615|extracellular space;","GO:0048018|receptor ligand activity;","K25542","TAFA2_3, FAM19A2_3; chemokine-like protein TAFA2/3"]
["ENSRNOG00000051216",89,7.389372787,37,2.380226213,3.104483409,1.634353222,{"v":1.1095e-09,"d":"1.11E-09"},{"v":2.2443e-09,"d":"2.24E-09"},"up","yes","AABR07038983.1","lncRNA","chrX:61138374-61144585:+","gi|149042264|gb|EDL95971.1|",370,{"v":1e-37,"d":"1.00E-37"},"rCG63291 [Rattus norvegicus]","gi|30268441|emb|AL831708.9|",1620,0,"Mouse DNA sequence from clone RP23-23B17 on chromosome X, complete sequence",".",".",".",".",".",".",".",".","pfam06993","DUF1304","Protein of unknown function (DUF1304). This family consists of several hypothetical bacterial proteins of around 120 residues in length. The function of this family is unknown.",".",".",".",".","."]
["ENSRNOG00000064111",32,2.656853137,2,0.128660876,20.65004694,4.368073156,{"v":1.20141e-09,"d":"1.20E-09"},{"v":2.42639e-09,"d":"2.43E-09"},"up","yes","Tnip3","protein_coding","chr4:94811097-94907605:+","gi|564303852|ref|XP_006225013.1|",1328,{"v":1E-180,"d":"1.00E-180"},"PREDICTED: TNFAIP3-interacting protein 3 isoform X1 [Rattus norvegicus]","gi|672018389|ref|XM_006224951.2|",1309,0,"PREDICTED: Rattus norvegicus TNFAIP3 interacting protein 3 (Tnip3), transcript variant X1, mRNA","Q96KP6",155,{"v":9e-42,"d":"9.00E-42"},"TNFAIP3-interacting protein 3",".",".",".",".","pfam15619","Lebercilin","Ciliary protein causing Leber congenital amaurosis disease. Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.",".",".",".",".","."]
["ENSRNOG00000000907",107,8.883852676,51,3.280852347,2.707788018,1.437114801,{"v":1.21236e-09,"d":"1.21E-09"},{"v":2.44773e-09,"d":"2.45E-09"},"up","yes","Alox5ap","protein_coding","chr12:5748944-5772986:-","gi|8392897|ref|NP_058956.1|",767,{"v":3e-99,"d":"3.00E-99"},"arachidonate 5-lipoxygenase-activating protein [Rattus norvegicus]","gi|55926225|ref|NM_017260.2|",934,0,"Rattus norvegicus arachidonate 5-lipoxygenase activating protein (Alox5ap), mRNA","P20291",300,{"v":1E-100,"d":"1.00E-100"},"Arachidonate 5-lipoxygenase-activating protein",".",".",".",".","pfam01124","MAPEG","MAPEG family. This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolizm). It includes proteins such as Prostaglandin E synthase. This enzyme catalyses the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.","GO:0002540|leukotriene production involved in inflammatory response;GO:0002675|positive regulation of acute inflammatory response;GO:0019370|leukotriene biosynthetic process;GO:0019372|lipoxygenase pathway;GO:0050790|regulation of catalytic activity;GO:0070207|protein homotrimerization;GO:0071277|cellular response to calcium ion;GO:0098869|cellular oxidant detoxification;","GO:0005634|nucleus;GO:0005635|nuclear envelope;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005829|cytosol;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0031965|nuclear membrane;","GO:0004051|arachidonate 5-lipoxygenase activity;GO:0004364|glutathione transferase activity;GO:0004464|leukotriene-C4 synthase activity;GO:0004602|glutathione peroxidase activity;GO:0008047|enzyme activator activity;GO:0019899|enzyme binding;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;GO:0047485|protein N-terminus binding;GO:0050544|arachidonic acid binding;","K20735","ALOX5AP, FLAP; arachidonate 5-lipoxygenase-activating protein"]
["ENSRNOG00000048321",30,2.490799816,0,0.032165219,77.43767604,6.274963752,{"v":1.22267e-09,"d":"1.22E-09"},{"v":2.46698e-09,"d":"2.47E-09"},"up","yes","Tnfsf8","protein_coding","chr5:77251373-77277421:-","gi|974987285|ref|NP_001305962.1|",1157,{"v":4e-146,"d":"4.00E-146"},"tumor necrosis factor superfamily member 8 [Rattus norvegicus]","gi|672019461|ref|XM_006225345.2|",2905,0,"PREDICTED: Rattus norvegicus tumor necrosis factor (ligand) superfamily, member 8 (Tnfsf8), transcript variant X2, mRNA","P32972",397,{"v":1E-127,"d":"1.00E-127"},"Tumor necrosis factor ligand superfamily member 8",".",".",".",".","pfam00229","TNF","TNF(tumor Necrosis Factor) family.","GO:0043374|CD8-positive, alpha-beta T cell differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050830|defense response to Gram-positive bacterium;","GO:0016021|integral component of membrane;","GO:0005164|tumor necrosis factor receptor binding;","K05471","TNFSF8, CD153; tumor necrosis factor ligand superfamily member 8"]
["ENSRNOG00000064255",86,7.140292805,35,2.251565336,3.171257209,1.665054894,{"v":1.28414e-09,"d":"1.28E-09"},{"v":2.58775e-09,"d":"2.59E-09"},"up","yes","ENSRNOG00000064255","protein_coding","chr13:84052493-84074492:+","gi|672027366|ref|XP_008761740.1|",2067,0,"PREDICTED: natural killer cell receptor 2B4 isoform X1 [Rattus norvegicus]","gi|672027365|ref|XM_008763518.1|",1724,0,"PREDICTED: Rattus norvegicus Cd244 molecule, natural killer cell receptor 2B4 (Cd244), transcript variant X1, mRNA","Q9JLM2",560,0,"Natural killer cell receptor 2B4",".",".",".",".","pfam11465","Receptor_2B4","Natural killer cell receptor 2B4. 2B4 is a transmembrane receptor which is expressed primarily on natural killer cells. It plays a role in activating NK-mediated cytotoxicity through its interaction with CD48 on target cells in a subset of CD8 T cells. The structure of 2B4 consists of an immunoglobulin variable domain fold and contains two beta-sheets. One of the beta-sheets, the six-stranded sheet, contains structural features that may have a role in ligand recognition and receptor function.",".",".",".",".","."]
["ENSRNOG00000015113",96,7.97055941,43,2.766208842,2.881401899,1.526770902,{"v":1.71663e-09,"d":"1.72E-09"},{"v":3.4226e-09,"d":"3.42E-09"},"up","yes","Mocos","protein_coding","chr18:15931654-15977187:+","gi|564392795|ref|XP_006254528.1|",4653,0,"PREDICTED: molybdenum cofactor sulfurase isoform X1 [Rattus norvegicus]","gi|672082732|ref|XM_006254466.2|",3105,0,"PREDICTED: Rattus norvegicus molybdenum cofactor sulfurase (Mocos), transcript variant X1, mRNA","Q14CH1",1653,0,"Molybdenum cofactor sulfurase","MA1950",254,{"v":6e-73,"d":"6.00E-73"},"COG0520","pfam00266","Aminotran_5","Aminotransferase class-V. This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.","GO:0006777|Mo-molybdopterin cofactor biosynthetic process;GO:0043545|molybdopterin cofactor metabolic process;",".","GO:0008265|Mo-molybdopterin cofactor sulfurase activity;GO:0016829|lyase activity;GO:0030151|molybdenum ion binding;GO:0030170|pyridoxal phosphate binding;GO:0102867|molybdenum cofactor sulfurtransferase activity;","K15631","ABA3; molybdenum cofactor sulfurtransferase [EC:2.8.1.9]"]
["ENSRNOG00000013554",71,5.894892897,25,1.608260955,3.665383332,1.873964086,{"v":2.15114e-09,"d":"2.15E-09"},{"v":4.26367E-9,"d":"4.26E-09"},"up","yes","Treml2","protein_coding","chr9:12694697-12705324:-","gi|109485725|ref|XP_001059150.1|",1670,0,"PREDICTED: trem-like transcript 2 protein isoform X2 [Rattus norvegicus]","gi|672023707|ref|XM_002727159.4|",2597,0,"PREDICTED: Rattus norvegicus triggering receptor expressed on myeloid cells-like 2 (Treml2), transcript variant X3, mRNA","Q2LA85",483,{"v":2e-157,"d":"2.00E-157"},"Trem-like transcript 2 protein",".",".",".",".","pfam07502","MANEC","MANEC domain. This region of similarity, comprising 8 conserved cysteines, is found in the N-terminal region of several membrane-associated and extracellular proteins. Although formerly called MANSC (for motif at N terminus with seven cysteines) it has now been renamed by MANEC (motif at N terminus with eight cysteines) by Richard Mitter and Stephen Fitzgerald after the discovery of an eighth conserved cysteine. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors.","GO:0042110|T cell activation;","GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0038023|signaling receptor activity;","K14364","TLT2; trem-like transcript 2 protein"]
["ENSRNOG00000006730",29,2.407773155,0,0.032165219,74.85642017,6.226054151,{"v":2.24533e-09,"d":"2.25E-09"},{"v":4.44347e-09,"d":"4.44E-09"},"up","yes","Ccr1l1","protein_coding","chr8:123589621-123612687:-","gi|157822295|ref|NP_001100342.1|",1641,0,"C-C chemokine receptor 1-like protein 1 [Rattus norvegicus]","gi|157822294|ref|NM_001106872.1|",1071,0,"Rattus norvegicus chemokine (C-C motif) receptor 1-like 1 (Ccr1l1), mRNA","P51676",567,0,"C-C chemokine receptor 1-like protein 1",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0019722|calcium-mediated signaling;GO:0060326|cell chemotaxis;GO:0070098|chemokine-mediated signaling pathway;GO:0090026|positive regulation of monocyte chemotaxis;","GO:0005737|cytoplasm;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0016493|C-C chemokine receptor activity;GO:0019957|C-C chemokine binding;GO:0035717|chemokine (C-C motif) ligand 7 binding;GO:0071791|chemokine (C-C motif) ligand 5 binding;","K04176","CCR1, CD191; C-C chemokine receptor type 1"]
["ENSRNOG00000007625",29,2.407773155,0,0.032165219,74.85642017,6.226054151,{"v":2.24533e-09,"d":"2.25E-09"},{"v":4.44347e-09,"d":"4.44E-09"},"up","yes","B3galt1","protein_coding","chr3:52253618-52825313:+","gi|585161461|ref|XP_006732944.1|",1797,0,"PREDICTED: beta-1,3-galactosyltransferase 1 [Leptonychotes weddellii]","gi|157822402|ref|NM_001108954.1|",2617,0,"Rattus norvegicus Beta-1,3-galactosyltransferase 1 (B3galt1), mRNA","Q9MYM7",685,0,"Beta-1,3-galactosyltransferase 1",".",".",".",".","pfam01762","Galactosyl_T","Galactosyltransferase. This family includes the galactosyltransferases UDP-galactose:2-acetamido-2-deoxy-D-glucose3beta-galactosyltransferase and UDP-Gal:beta-GlcNAc beta 1,3-galactosyltranferase. Specific galactosyltransferases transfer galactose to GlcNAc terminal chains in the synthesis of the lacto-series oligosaccharides types 1 and 2.","GO:0006486|protein glycosylation;GO:0006682|galactosylceramide biosynthetic process;GO:0009312|oligosaccharide biosynthetic process;GO:0030259|lipid glycosylation;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0008194|UDP-glycosyltransferase activity;GO:0008499|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity;GO:0016757|transferase activity, transferring glycosyl groups;","K07819","B3GALT1; beta-1,3-galactosyltransferase 1 [EC:2.4.1.86]"]
["ENSRNOG00000069032",90,7.472399447,39,2.508887089,2.978372155,1.574524034,{"v":2.45891e-09,"d":"2.46E-09"},{"v":4.85714E-9,"d":"4.86E-09"},"up","yes","ENSRNOG00000069032","protein_coding","chr7:109179359-109187093:-","gi|149066036|gb|EDM15909.1|",1453,0,"rCG65936 [Rattus norvegicus]","gi|298906619|emb|FQ225154.1|",1351,0,"Rattus norvegicus TL0AEA54YP09 mRNA sequence","O95236",184,{"v":3E-51,"d":"3.00E-51"},"Apolipoprotein L3",".",".",".",".","pfam05461","ApoL","Apolipoprotein L. Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.",".",".",".",".","."]
["ENSRNOG00000055650",57,4.73251965,16,1.029287011,4.597862015,2.20096317,{"v":2.64408e-09,"d":"2.64E-09"},{"v":5.20682e-09,"d":"5.21E-09"},"up","yes","Pou2f2","protein_coding","chr1:80685741-80724261:-","gi|982316779|ref|XP_015297560.1|",1450,0,"PREDICTED: POU domain, class 2, transcription factor 2 isoform X11 [Macaca fascicularis]","gi|755519209|ref|XM_006539659.2|",2297,0,"PREDICTED: Mus musculus POU domain, class 2, transcription factor 2 (Pou2f2), transcript variant X14, mRNA","P09086",491,{"v":5e-157,"d":"5.00E-157"},"POU domain, class 2, transcription factor 2",".",".",".",".","pfam00157","Pou","Pou domain - N-terminal to homeobox domain.","GO:0002335|mature B cell differentiation;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0032755|positive regulation of interleukin-6 production;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048469|cell maturation;GO:0098586|cellular response to virus;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0043231|intracellular membrane-bounded organelle;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0019904|protein domain specific binding;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09364","POU2F, OTF; POU domain transcription factor, class 2"]
["ENSRNOG00000043374",116,9.631092621,60,3.859826291,2.495214006,1.319163556,{"v":3.0369e-09,"d":"3.04E-09"},{"v":5.95104e-09,"d":"5.95E-09"},"up","yes","RGD1566099","protein_coding","chr13:50413785-50419120:-","gi|157820769|ref|NP_001101817.1|",382,{"v":2E-41,"d":"2.00E-41"},"uncharacterized protein C1orf53 homolog [Rattus norvegicus]","gi|157820768|ref|NM_001108347.1|",467,0,"Rattus norvegicus similar to novel protein (RGD1566099), mRNA",".",".",".",".",".",".",".",".","pfam10436","BCDHK_Adom3","Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase. Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal.",".",".",".",".","."]
["ENSRNOG00000042496",111,9.215959318,56,3.602504538,2.558208941,1.3551341,{"v":3.18965E-9,"d":"3.19E-09"},{"v":6.2408e-09,"d":"6.24E-09"},"up","yes","Cyp4f5","protein_coding","chr7:11544082-11558978:+","gi|564358439|ref|XP_006241113.1|",2495,0,"PREDICTED: cytochrome P450 4F5 isoform X1 [Rattus norvegicus]","gi|672057977|ref|XM_006241051.2|",2389,0,"PREDICTED: Rattus norvegicus cytochrome P450, family 4, subfamily f, polypeptide 5 (Cyp4f5), transcript variant X1, mRNA","P51870",962,0,"Cytochrome P450 4F5","BH0579",154,{"v":2e-39,"d":"2.00E-39"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0006691|leukotriene metabolic process;GO:0006954|inflammatory response;","GO:0005789|endoplasmic reticulum membrane;GO:0016020|membrane;","GO:0004497|monooxygenase activity;GO:0005506|iron ion binding;GO:0016705|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0020037|heme binding;GO:0070330|aromatase activity;","K00490","CYP4F; cytochrome P450 family 4 subfamily F [EC:1.14.14.1]"]
["ENSRNOG00000060395",37,3.071986439,5,0.321652191,9.550646711,3.255598427,{"v":3.44689e-09,"d":"3.45E-09"},{"v":6.72355E-9,"d":"6.72E-09"},"up","yes","AABR07025301.1","protein_coding","chr16:29188184-29188562:-","gi|55778620|gb|AAH86595.1|",202,{"v":5e-19,"d":"5.00E-19"},"Cbx3 protein [Rattus norvegicus]","gi|55778619|gb|BC086595.1|",210,{"v":1e-104,"d":"1.00E-104"},"Rattus norvegicus chromobox homolog 3 (HP1 gamma homolog, Drosophila), mRNA (cDNA clone IMAGE:7311933), complete cds","Q5R6X7",54.3,2e-09,"Chromobox protein homolog 3",".",".",".",".","pfam14061","Mtf2_C","Polycomb-like MTF2 factor 2. Mammalian Polycomb-like gene MTF2/PCL2 forms a complex with Polycomb repressive complex-2 (PRC2) and collaborates with PRC1 to achieve repression of Hox gene expression. The human MTF2 gene is expressed in three splicing variants, each of them contains the short C-terminal domain defined here. The domain is subject to structure determination by the Joint Center of Structural Genomics.",".",".",".",".","."]
["ENSRNOG00000012175",39,3.23803976,6,0.385982629,8.389081571,3.068512874,{"v":3.5019e-09,"d":"3.50E-09"},{"v":6.82461e-09,"d":"6.82E-09"},"up","yes","Nfatc2","protein_coding","chr3:157198872-157328325:-","gi|157821773|ref|NP_001101275.1|",4154,0,"nuclear factor of activated T-cells, cytoplasmic 2 [Rattus norvegicus]","gi|157821772|ref|NM_001107805.1|",2824,0,"Rattus norvegicus nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (Nfatc2), mRNA","Q60591",1571,0,"Nuclear factor of activated T-cells, cytoplasmic 2",".",".",".",".","pfam00554","RHD","Rel homology domain (RHD). Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See pfam01833) that binds to DNA.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001816|cytokine production;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006974|cellular response to DNA damage stimulus;GO:0008150|biological_process;GO:0009410|response to xenobiotic stimulus;GO:0010628|positive regulation of gene expression;GO:0014904|myotube cell development;GO:0016477|cell migration;GO:0030890|positive regulation of B cell proliferation;GO:0033173|calcineurin-NFAT signaling cascade;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050853|B cell receptor signaling pathway;GO:1901741|positive regulation of myoblast fusion;GO:1905064|negative regulation of vascular smooth muscle cell differentiation;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:1990904|ribonucleoprotein complex;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003682|chromatin binding;GO:0003700|DNA-binding transcription factor activity;GO:0008134|transcription factor binding;GO:0019902|phosphatase binding;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K17332","NFATC2, NFAT1, NFATP; nuclear factor of activated T-cells, cytoplasmic 2"]
["ENSRNOG00000028250",39,3.23803976,6,0.385982629,8.389081571,3.068512874,{"v":3.5019e-09,"d":"3.50E-09"},{"v":6.82461e-09,"d":"6.82E-09"},"up","yes","Lax1","protein_coding","chr13:45134834-45145381:-","gi|62945342|ref|NP_001017491.1|",1979,0,"lymphocyte transmembrane adapter 1 [Rattus norvegicus]","gi|62945341|ref|NM_001017491.1|",2209,0,"Rattus norvegicus lymphocyte transmembrane adaptor 1 (Lax1), mRNA","Q5FVQ5",766,0,"Lymphocyte transmembrane adapter 1",".",".",".",".","pfam03326","Herpes_TAF50","Herpesvirus transcription activation factor (transactivator). This family includes EBV BRLF1 and similar ORF 50 proteins from other herpesviruses.","GO:0002250|adaptive immune response;GO:0006955|immune response;GO:0035556|intracellular signal transduction;GO:0042113|B cell activation;GO:0043407|negative regulation of MAP kinase activity;GO:0046649|lymphocyte activation;GO:0050851|antigen receptor-mediated signaling pathway;GO:0050868|negative regulation of T cell activation;","GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0019901|protein kinase binding;GO:0042169|SH2 domain binding;",".","."]
["ENSRNOG00000008001",77,6.39305286,30,1.929913146,3.312611697,1.727969101,{"v":3.73808E-9,"d":"3.74E-09"},{"v":7.26936e-09,"d":"7.27E-09"},"up","yes","Rab3b","protein_coding","chr5:123644423-123697401:+","gi|564352032|ref|XP_006238593.1|",1233,{"v":2e-168,"d":"2.00E-168"},"PREDICTED: ras-related protein Rab-3B isoform X1 [Rattus norvegicus]","gi|672053258|ref|XM_006238531.2|",1051,0,"PREDICTED: Rattus norvegicus RAB3B, member RAS oncogene family (Rab3b), transcript variant X1, mRNA","Q63941",450,{"v":2e-158,"d":"2.00E-158"},"Ras-related protein Rab-3B",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0006904|vesicle docking involved in exocytosis;GO:0009306|protein secretion;GO:0017157|regulation of exocytosis;GO:0018125|peptidyl-cysteine methylation;GO:0019882|antigen processing and presentation;GO:0051586|positive regulation of dopamine uptake involved in synaptic transmission;GO:0072659|protein localization to plasma membrane;GO:0097494|regulation of vesicle size;GO:0098693|regulation of synaptic vesicle cycle;","GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0008021|synaptic vesicle;GO:0030141|secretory granule;GO:0031982|vesicle;GO:0048471|perinuclear region of cytoplasm;GO:0098691|dopaminergic synapse;GO:0098993|anchored component of synaptic vesicle membrane;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0019003|GDP binding;GO:0030742|GTP-dependent protein binding;GO:0031489|myosin V binding;","K06108","RAB3B; Ras-related protein Rab-3B"]
["ENSRNOG00000001138",155,12.86913238,94,6.047061189,2.128163083,1.08960871,{"v":3.8321e-09,"d":"3.83E-09"},{"v":7.44089e-09,"d":"7.44E-09"},"up","yes","Taok3","protein_coding","chr12:39314027-39461244:-","gi|66730484|ref|NP_001019425.1|",4113,0,"serine/threonine-protein kinase TAO3 [Rattus norvegicus]","gi|66730483|ref|NM_001024254.1|",1814,0,"Rattus norvegicus TAO kinase 3 (Taok3), mRNA","Q53UA7",1588,0,"Serine/threonine-protein kinase TAO3",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0000165|MAPK cascade;GO:0006281|DNA repair;GO:0006468|protein phosphorylation;GO:0006974|cellular response to DNA damage stimulus;GO:0007095|mitotic G2 DNA damage checkpoint;GO:0032874|positive regulation of stress-activated MAPK cascade;GO:0035556|intracellular signal transduction;GO:0043408|regulation of MAPK cascade;GO:0043507|positive regulation of JUN kinase activity;GO:0046329|negative regulation of JNK cascade;GO:0046330|positive regulation of JNK cascade;GO:0046777|protein autophosphorylation;GO:0048812|neuron projection morphogenesis;","GO:0005737|cytoplasm;","GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;GO:0016740|transferase activity;","K04429","TAO; thousand and one amino acid protein kinase [EC:2.7.11.1]"]
["ENSRNOG00000047782",61,5.064626292,19,1.222278326,4.143594946,2.05088298,{"v":3.88756e-09,"d":"3.89E-09"},{"v":7.544e-09,"d":"7.54E-09"},"up","yes","RGD1309808","protein_coding","chr7:109305709-109322865:+","gi|564360837|ref|XP_006241996.1|",1488,0,"PREDICTED: apolipoprotein L3 isoform X2 [Rattus norvegicus]","gi|672059714|ref|XM_006241935.2|",2258,0,"PREDICTED: Rattus norvegicus similar to apolipoprotein L2; apolipoprotein L-II (RGD1309808), transcript variant X2, mRNA","O95236",161,{"v":9e-42,"d":"9.00E-42"},"Apolipoprotein L3",".",".",".",".","pfam05461","ApoL","Apolipoprotein L. Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.","GO:0006869|lipid transport;GO:0042157|lipoprotein metabolic process;","GO:0005576|extracellular region;",".","K14480","APOL; apolipoprotein L"]
["ENSRNOG00000003468",98,8.136612731,46,2.959200157,2.749598642,1.459221044,{"v":3.9988e-09,"d":"4.00E-09"},{"v":7.75515e-09,"d":"7.76E-09"},"up","yes","Capn8","protein_coding","chr13:94253054-94316146:+","gi|28849961|ref|NP_579843.2|",3790,0,"calpain-8 [Rattus norvegicus]","gi|28849960|ref|NM_133309.2|",2402,0,"Rattus norvegicus calpain 8 (Capn8), mRNA","Q78EJ9",1464,0,"Calpain-8",".",".",".",".","pfam00648","Peptidase_C2","Calpain family cysteine protease.","GO:0006508|proteolysis;GO:0007586|digestion;GO:1990092|calcium-dependent self proteolysis;","GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;","GO:0004198|calcium-dependent cysteine-type endopeptidase activity;GO:0005509|calcium ion binding;GO:0042802|identical protein binding;","K08577","CAPN8; calpain-8 [EC:3.4.22.-]"]
["ENSRNOG00000026110",28,2.324746495,0,0.032165219,72.2751643,6.175428078,{"v":4.13829e-09,"d":"4.14E-09"},{"v":8.01837e-09,"d":"8.02E-09"},"up","yes","Scml4","protein_coding","chr20:46347413-46440103:+","gi|564398269|ref|XP_006256634.1|",2184,0,"PREDICTED: sex comb on midleg-like protein 4 isoform X1 [Rattus norvegicus]","gi|157823028|ref|NM_001107638.1|",3765,0,"Rattus norvegicus sex comb on midleg-like 4 (Drosophila) (Scml4), mRNA","Q80VG1",797,0,"Sex comb on midleg-like protein 4",".",".",".",".","pfam12140","DUF3588","Protein of unknown function (DUF3588). This family of proteins is found in eukaryotes. Proteins in this family are typically between 129 and 866 amino acids in length, and the family is found in association with pfam02820. The exact function of this family is not known.","GO:0045892|negative regulation of transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003682|chromatin binding;GO:0042393|histone binding;","K11466","SCML4; sex comb on midleg-like protein 4"]
["ENSRNOG00000051489",28,2.324746495,0,0.032165219,72.2751643,6.175428078,{"v":4.13829e-09,"d":"4.14E-09"},{"v":8.01837e-09,"d":"8.02E-09"},"up","yes","Klra1","protein_coding","chr4:164606629-164628406:-","gi|57527630|ref|NP_001009718.1|",1404,0,"killer cell lectin-like receptor, subfamily A, member 2 [Rattus norvegicus]","gi|57527629|ref|NM_001009718.1|",1162,0,"Rattus norvegicus killer cell lectin-like receptor, subfamily A, member 2 (Klra2), mRNA","Q60652",350,{"v":6e-118,"d":"6.00E-118"},"Killer cell lectin-like receptor 5",".",".",".",".","pfam08391","Ly49","Ly49-like protein, N-terminal region. The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000022490",115,9.54806596,60,3.859826291,2.47370354,1.306672612,{"v":4.60794e-09,"d":"4.61E-09"},{"v":8.88262e-09,"d":"8.88E-09"},"up","yes","ENSRNOG00000022490","protein_coding","chr3:13804033-13804473:-","gi|478495069|ref|XP_004421882.1|",583,{"v":3e-74,"d":"3.00E-74"},"PREDICTED: cytochrome c oxidase subunit 5A, mitochondrial [Ceratotherium simum simum]","gi|672016567|ref|XR_600114.1|",441,0,"PREDICTED: Rattus norvegicus Cytochrome c oxidase subunit 5A, mitochondrial-like (LOC100361008), misc_RNA","B0VYY3",227,{"v":3e-75,"d":"3.00E-75"},"Cytochrome c oxidase subunit 5A, mitochondrial",".",".",".",".","pfam02284","COX5A","Cytochrome c oxidase subunit Va. Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of cytochrome c oxidase subunit Va.",".",".",".",".","."]
["ENSRNOG00000011550",46,3.819226384,10,0.643304382,5.936888496,2.569707017,{"v":4.72427e-09,"d":"4.72E-09"},{"v":9.09042e-09,"d":"9.09E-09"},"up","yes","Kcnab2","protein_coding","chr5:162901896-162988243:-","gi|568930660|ref|XP_006538649.1|",1699,0,"PREDICTED: voltage-gated potassium channel subunit beta-2 isoform X6 [Mus musculus]","gi|755509316|ref|XM_006538587.2|",677,0,"PREDICTED: Mus musculus potassium voltage-gated channel, shaker-related subfamily, beta member 2 (Kcnab2), transcript variant X10, mRNA","P62483",605,0,"Voltage-gated potassium channel subunit beta-2","TM0313",262,{"v":4e-81,"d":"4.00E-81"},"COG0667","pfam00248","Aldo_ket_red","Aldo/keto reductase family. This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.","GO:0002244|hematopoietic progenitor cell differentiation;GO:0045445|myoblast differentiation;GO:0050905|neuromuscular process;GO:0070995|NADPH oxidation;GO:0071805|potassium ion transmembrane transport;GO:0098900|regulation of action potential;GO:1901379|regulation of potassium ion transmembrane transport;GO:2000008|regulation of protein localization to cell surface;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005874|microtubule;GO:0008076|voltage-gated potassium channel complex;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0030424|axon;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0034705|potassium channel complex;GO:0043005|neuron projection;GO:0043679|axon terminus;GO:0044224|juxtaparanode region of axon;GO:1990031|pinceau fiber;","GO:0004033|aldo-keto reductase (NADP) activity;GO:0005249|voltage-gated potassium channel activity;GO:0005515|protein binding;GO:0015459|potassium channel regulator activity;GO:0044325|ion channel binding;GO:0044877|protein-containing complex binding;GO:0047834|D-threo-aldose 1-dehydrogenase activity;","K04883","KCNAB2; potassium voltage-gated channel Shaker-related subfamily A, beta member 2"]
["ENSRNOG00000019894",46,3.819226384,10,0.643304382,5.936888496,2.569707017,{"v":4.72427e-09,"d":"4.72E-09"},{"v":9.09042e-09,"d":"9.09E-09"},"up","yes","Izumo1r","protein_coding","chr8:11725863-11748465:-","gi|293349014|ref|XP_002727032.1|",1296,{"v":2E-175,"d":"2.00E-175"},"PREDICTED: sperm-egg fusion protein Juno [Rattus norvegicus]","gi|672061104|ref|XM_001072998.4|",1060,0,"PREDICTED: Rattus norvegicus folate receptor 4, delta (Folr4), mRNA","Q9EQF4",411,{"v":1e-140,"d":"1.00E-140"},"Sperm-egg fusion protein Juno",".",".",".",".","pfam03024","Folate_rec","Folate receptor family. This family includes the folate receptor which binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. These proteins are attached to the membrane by a GPI-anchor. The proteins contain 16 conserved cysteines that form eight disulphide bridges.","GO:0007155|cell adhesion;GO:0007338|single fertilization;GO:0007342|fusion of sperm to egg plasma membrane involved in single fertilization;GO:0035036|sperm-egg recognition;","GO:0031362|anchored component of external side of plasma membrane;","GO:0005102|signaling receptor binding;GO:0038023|signaling receptor activity;","K25530","IZUMO1R, FOLR4; sperm-egg fusion protein Juno"]
["ENSRNOG00000009862",44,3.653173063,9,0.578973944,6.309736566,2.657579773,{"v":5.40424e-09,"d":"5.40E-09"},{"v":1.03366E-8,"d":"1.03E-08"},"up","yes","Olfm1","protein_coding","chr3:11520729-11558239:+","gi|17865343|ref|NP_446025.1|",2639,0,"noelin precursor [Rattus norvegicus]","gi|17865342|ref|NM_053573.1|",2753,0,"Rattus norvegicus olfactomedin 1 (Olfm1), mRNA","Q62609",1021,0,"Noelin",".",".",".",".","pfam02191","OLF","Olfactomedin-like domain.","GO:0003190|atrioventricular valve formation;GO:0007399|nervous system development;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010718|positive regulation of epithelial to mesenchymal transition;GO:0023041|neuronal signal transduction;GO:0030516|regulation of axon extension;GO:0043065|positive regulation of apoptotic process;GO:0060317|cardiac epithelial to mesenchymal transition;GO:1902003|regulation of amyloid-beta formation;GO:1902430|negative regulation of amyloid-beta formation;GO:2001223|negative regulation of neuron migration;","GO:0005615|extracellular space;GO:0005783|endoplasmic reticulum;GO:0030424|axon;GO:0032281|AMPA glutamate receptor complex;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0044295|axonal growth cone;GO:0097060|synaptic membrane;GO:0098978|glutamatergic synapse;GO:0099243|extrinsic component of synaptic membrane;","GO:0001540|amyloid-beta binding;GO:0042802|identical protein binding;","K25444","OLFM1; noelin"]
["ENSRNOG00000037167",42,3.487119742,8,0.514643505,6.775796653,2.760390579,{"v":6.02545e-09,"d":"6.03E-09"},{"v":1.14904e-08,"d":"1.15E-08"},"up","yes","Rtp3","protein_coding","chr8:110970160-110974699:-","gi|157824049|ref|NP_001101660.1|",1754,0,"receptor-transporting protein 3 [Rattus norvegicus]","gi|157824048|ref|NM_001108190.1|",1958,0,"Rattus norvegicus receptor (chemosensory) transporter protein 3 (Rtp3), mRNA","Q5QGU6",418,{"v":1e-137,"d":"1.00E-137"},"Receptor-transporting protein 3",".",".",".",".","pfam13695","zf-3CxxC","Zinc-binding domain. This is a family with several pairs of CxxC motifs possibly representing a multiple zinc-binding region. Only one pair of cysteines is associated with a highly conserved histidine residue.","GO:0001580|detection of chemical stimulus involved in sensory perception of bitter taste;GO:0006612|protein targeting to membrane;GO:0051205|protein insertion into membrane;","GO:0005737|cytoplasm;GO:0016021|integral component of membrane;","GO:0031849|olfactory receptor binding;",".","."]
["ENSRNOG00000000478",38,3.1550131,6,0.385982629,8.173976915,3.031038169,{"v":6.78102e-09,"d":"6.78E-09"},{"v":1.28813e-08,"d":"1.29E-08"},"up","yes","ENSRNOG00000000478","protein_coding","chr20:4981263-4981668:-","gi|293356975|ref|XP_002729038.1|",311,{"v":2E-35,"d":"2.00E-35"},"PREDICTED: protein kish-A [Rattus norvegicus]","gi|298891975|emb|FQ220821.1|",193,{"v":3e-95,"d":"3.00E-95"},"Rattus norvegicus TL0ADA41YJ03 mRNA sequence","Q9CR64",123,{"v":1e-36,"d":"1.00E-36"},"Protein kish-A",".",".",".",".","pfam06842","DUF1242","Protein of unknown function (DUF1242). This family consists of a number of eukaryotic proteins of around 72 residues in length. The function of this family is unknown.",".",".",".",".","."]
["ENSRNOG00000029993",27,2.241719834,0,0.032165219,69.69390843,6.122960658,{"v":7.65562e-09,"d":"7.66E-09"},{"v":1.44997e-08,"d":"1.45E-08"},"up","yes","Kynu","protein_coding","chr3:27778772-27929488:+","gi|55584141|sp|P70712.2|KYNU_RAT",2372,0,"RecName: Full=Kynureninase; AltName: Full=L-kynurenine hydrolase","gi|51261162|gb|BC078762.1|",1438,0,"Rattus norvegicus kynureninase (L-kynurenine hydrolase), mRNA (cDNA clone MGC:93273 IMAGE:7128911), complete cds","P70712",918,0,"Kynureninase","YLR231c",320,{"v":3e-101,"d":"3.00E-101"},"COG3844","pfam00266","Aminotran_5","Aminotransferase class-V. This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.","GO:0006569|tryptophan catabolic process;GO:0007568|aging;GO:0009435|NAD biosynthetic process;GO:0019441|tryptophan catabolic process to kynurenine;GO:0019442|tryptophan catabolic process to acetyl-CoA;GO:0019805|quinolinate biosynthetic process;GO:0034341|response to interferon-gamma;GO:0034354|'de novo' NAD biosynthetic process from tryptophan;GO:0034516|response to vitamin B6;GO:0043420|anthranilate metabolic process;GO:0097053|L-kynurenine catabolic process;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;","GO:0030170|pyridoxal phosphate binding;GO:0030429|kynureninase activity;GO:0042803|protein homodimerization activity;GO:0061981|3-hydroxykynureninase activity;","K01556","KYNU, kynU; kynureninase [EC:3.7.1.3]"]
["ENSRNOG00000020309",116,9.631092621,62,3.988487167,2.414723231,1.271857841,{"v":8.2138e-09,"d":"8.21E-09"},{"v":1.55246E-8,"d":"1.55E-08"},"up","yes","Gfra3","protein_coding","chr18:26297829-26326105:-","gi|61097945|ref|NP_445850.1|",1848,0,"GDNF family receptor alpha-3 precursor [Rattus norvegicus]","gi|61097944|ref|NM_053398.1|",2044,0,"Rattus norvegicus GDNF family receptor alpha 3 (Gfra3), mRNA","O35118",675,0,"GDNF family receptor alpha-3",".",".",".",".","pfam02351","GDNF","GDNF/GAS1 domain. This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.","GO:0001764|neuron migration;GO:0007399|nervous system development;GO:0007411|axon guidance;GO:0035860|glial cell-derived neurotrophic factor receptor signaling pathway;GO:0048485|sympathetic nervous system development;GO:0048666|neuron development;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0043235|receptor complex;","GO:0008046|axon guidance receptor activity;GO:0016167|glial cell-derived neurotrophic factor receptor activity;GO:0038023|signaling receptor activity;","K19895","GFRA; GDNF family receptor alpha"]
["ENSRNOG00000042465",55,4.566466329,16,1.029287011,4.436533523,2.14943287,{"v":8.34881e-09,"d":"8.35E-09"},{"v":1.57705e-08,"d":"1.58E-08"},"up","yes","Zbtb32","protein_coding","chr1:85841931-85844236:-","gi|157816985|ref|NP_001102987.1|",2239,0,"zinc finger and BTB domain-containing protein 32 [Rattus norvegicus]","gi|672035867|ref|XM_006228793.2|",1756,0,"PREDICTED: Rattus norvegicus zinc finger and BTB domain containing 32 (Zbtb32), transcript variant X1, mRNA","Q9JKD9",719,0,"Zinc finger and BTB domain-containing protein 32",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001817|regulation of cytokine production;GO:0006357|regulation of transcription by RNA polymerase II;GO:0030097|hemopoiesis;GO:0042098|T cell proliferation;","GO:0000228|nuclear chromosome;GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0003714|transcription corepressor activity;GO:0008270|zinc ion binding;GO:0042802|identical protein binding;GO:1990837|sequence-specific double-stranded DNA binding;","K10506","ZBTB32, TZFP; zinc finger and BTB domain-containing protein 32"]
["ENSRNOG00000005132",78,6.476079521,32,2.058574022,3.145905589,1.653475375,{"v":8.8448e-09,"d":"8.84E-09"},{"v":1.66729e-08,"d":"1.67E-08"},"up","yes","Slc52a3","protein_coding","chr3:140509473-140514096:+","gi|564343591|ref|XP_006235300.1|",2210,0,"PREDICTED: solute carrier family 52, riboflavin transporter, member 3 isoform X1 [Rattus norvegicus]","gi|672047468|ref|XM_006235238.2|",2221,0,"PREDICTED: Rattus norvegicus solute carrier family 52, riboflavin transporter, member 3 (Slc52a3), transcript variant X2, mRNA","Q4FZU9",853,0,"Solute carrier family 52, riboflavin transporter, member 3",".",".",".",".","pfam06237","DUF1011","Protein of unknown function (DUF1011). Family of uncharacterized eukaryotic proteins.","GO:0007605|sensory perception of sound;GO:0032218|riboflavin transport;GO:0034605|cellular response to heat;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;","GO:0032217|riboflavin transmembrane transporter activity;","K14620","SLC52A3, RFT2; riboflavin transporter 2"]
["ENSRNOG00000026989",27,2.241719834,1,0.064330438,34.84695422,5.122960658,{"v":9.08882e-09,"d":"9.09E-09"},{"v":1.71178e-08,"d":"1.71E-08"},"up","yes","Gapt","protein_coding","chr2:41927532-41932093:-","gi|157823571|ref|NP_001102961.1|",712,{"v":9e-87,"d":"9.00E-87"},"protein GAPT [Rattus norvegicus]","gi|672041425|ref|XM_006231916.2|",1953,0,"PREDICTED: Rattus norvegicus Grb2-binding adaptor protein, transmembrane (Gapt), transcript variant X1, mRNA","Q8CB93",208,{"v":1E-61,"d":"1.00E-61"},"Protein GAPT",".",".",".",".","pfam11770","GAPT","GRB2-binding adapter (GAPT). This is a family of transmembrane proteins which bind the growth factor receptor-bound protein 2 (GRB2) in B cells. In contrast to other transmembrane adaptor proteins, GAPT is not phosphorylated upon BCR ligation. It associates with GRB2 constitutively through its proline-rich region.","GO:0001782|B cell homeostasis;GO:0002322|B cell proliferation involved in immune response;GO:0002381|immunoglobulin production involved in immunoglobulin mediated immune response;","GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;",".",".","."]
["ENSRNOG00000005929",31,2.573826476,3,0.192991315,13.33648865,3.737306966,{"v":1.11968E-8,"d":"1.12E-08"},{"v":2.09951e-08,"d":"2.10E-08"},"up","yes","Them6","protein_coding","chr7:106606570-106609746:+","gi|56090359|ref|NP_001007659.1|",980,{"v":9e-128,"d":"9.00E-128"},"protein THEM6 precursor [Rattus norvegicus]","gi|56090358|ref|NM_001007658.1|",1541,0,"Rattus norvegicus thioesterase superfamily member 6 (Them6), mRNA","Q5XIE1",382,{"v":3e-129,"d":"3.00E-129"},"Protein THEM6",".",".",".",".","pfam13279","4HBT_2","Thioesterase-like superfamily. This family contains a wide variety of enzymes, principally thioesterases. These enzymes are part of the Hotdog fold superfamily.","GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005576|extracellular region;","GO:0003674|molecular_function;",".","."]
["ENSRNOG00000020263",35,2.905933118,5,0.321652191,9.034395538,3.175428078,{"v":1.31778E-8,"d":"1.32E-08"},{"v":2.45442e-08,"d":"2.45E-08"},"up","yes","Atp1a3","protein_coding","chr1:80572796-80601918:-","gi|755519440|ref|XP_011248822.1|",5263,0,"PREDICTED: sodium/potassium-transporting ATPase subunit alpha-3 isoform X3 [Mus musculus]","gi|672034923|ref|XM_008758888.1|",3450,0,"PREDICTED: Rattus norvegicus ATPase, Na+/K+ transporting, alpha 3 polypeptide (Atp1a3), transcript variant X1, mRNA","P06687",2006,0,"Sodium/potassium-transporting ATPase subunit alpha-3","MA4378",648,0,"COG0474","pfam00122","E1-E2_ATPase","E1-E2 ATPase.","GO:0006813|potassium ion transport;GO:0006814|sodium ion transport;GO:0006883|cellular sodium ion homeostasis;GO:0007613|memory;GO:0008344|adult locomotory behavior;GO:0008542|visual learning;GO:0009410|response to xenobiotic stimulus;GO:0010248|establishment or maintenance of transmembrane electrochemical gradient;GO:0021987|cerebral cortex development;GO:0030007|cellular potassium ion homeostasis;GO:0035235|ionotropic glutamate receptor signaling pathway;GO:0036376|sodium ion export across plasma membrane;GO:0060048|cardiac muscle contraction;GO:0071300|cellular response to retinoic acid;GO:0086036|regulation of cardiac muscle cell membrane potential;GO:0097067|cellular response to thyroid hormone stimulus;GO:1902600|proton transmembrane transport;GO:1904646|cellular response to amyloid-beta;GO:1990535|neuron projection maintenance;GO:1990573|potassium ion import across plasma membrane;","GO:0001917|photoreceptor inner segment;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005890|sodium:potassium-exchanging ATPase complex;GO:0016020|membrane;GO:0030424|axon;GO:0031090|organelle membrane;GO:0042383|sarcolemma;GO:0043025|neuronal cell body;GO:0043209|myelin sheath;GO:0044305|calyx of Held;GO:0044326|dendritic spine neck;GO:0044327|dendritic spine head;GO:0045202|synapse;GO:0098794|postsynapse;GO:0098984|neuron to neuron synapse;GO:0099056|integral component of presynaptic membrane;","GO:0001540|amyloid-beta binding;GO:0005391|sodium:potassium-exchanging ATPase activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0031748|D1 dopamine receptor binding;GO:0043395|heparan sulfate proteoglycan binding;GO:0046872|metal ion binding;GO:0051087|chaperone binding;GO:0086037|sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential;GO:0099520|ion antiporter activity involved in regulation of presynaptic membrane potential;","K01539","ATP1A; sodium/potassium-transporting ATPase subunit alpha [EC:7.2.2.13]"]
["ENSRNOG00000067948",35,2.905933118,5,0.321652191,9.034395538,3.175428078,{"v":1.31778E-8,"d":"1.32E-08"},{"v":2.45442e-08,"d":"2.45E-08"},"up","yes","Metazoa_SRP","misc_RNA","chr6:87839673-87839972:-","gi|594691438|ref|XP_007193055.1|",518,{"v":5e-63,"d":"5.00E-63"},"PREDICTED: uncharacterized protein LOC103017900 [Balaenoptera acutorostrata scammoni]","gi|527047032|tpe|HG323686.1|",300,{"v":1e-154,"d":"1.00E-154"},"TPA: Mus musculus SRP RNA for signal recognition particle RNA",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSRNOG00000048202",26,2.158693174,0,0.032165219,67.11265257,6.068512874,{"v":1.42172E-8,"d":"1.42E-08"},{"v":2.64109e-08,"d":"2.64E-08"},"up","yes","AABR07038553.1","protein_coding","chrX:50886684-50888014:-","gi|564399346|ref|XP_006257053.1|",1493,0,"PREDICTED: melanoma-associated antigen B2-like [Rattus norvegicus]","gi|672087738|ref|XM_006256991.2|",884,0,"PREDICTED: Rattus norvegicus melanoma antigen family B 1-like 1 (mageb1l1), transcript variant X2, mRNA","A2A9R3",328,{"v":2e-106,"d":"2.00E-106"},"Melanoma-associated antigen B4",".",".",".",".","pfam01454","MAGE","MAGE family. The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumors but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.",".",".",".",".","."]
["ENSRNOG00000069083",105,8.717799355,54,3.473843662,2.509554316,1.327431172,{"v":1.43907E-8,"d":"1.44E-08"},{"v":2.67255E-8,"d":"2.67E-08"},"up","yes","ENSRNOG00000069083","lncRNA","chr12:34123824-34128516:-","gi|149038339|gb|EDL92699.1|",227,{"v":5e-18,"d":"5.00E-18"},"rCG63222 [Rattus norvegicus]","gi|169235020|gb|AC104314.8|",3572,0,"Rattus norvegicus BAC CH230-136I5 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam02028","BCCT","BCCT family transporter.",".",".",".",".","."]
["ENSRNOG00000069647",60,4.981599631,20,1.286608764,3.871883802,1.953035657,{"v":1.54131e-08,"d":"1.54E-08"},{"v":2.85083e-08,"d":"2.85E-08"},"up","yes","ENSRNOG00000069647","protein_coding","chr15:908691-1007927:+","gi|149031281|gb|EDL86288.1|",562,{"v":1e-63,"d":"1.00E-63"},"rCG41842 [Rattus norvegicus]","gi|71044101|gb|AC154795.2|",587,0,"Mus musculus BAC clone RP24-486D21 from chromosome 14, complete sequence",".",".",".",".",".",".",".",".","pfam04425","Bul1_N","Bul1 N terminus. This family contains the N terminus of Saccharomyces cerevisiae Bul1. Bul1 binds the ubiquitin ligase Rsp5, via an N terminal PPSY motif. The complex containing Bul1 and Rsp5 is involved in intracellular trafficking of the general amino acid permease Gap1, degradation of Rog1 in cooperation with Bul2 and GSK-3, and mitochondrial inheritance. Bul1 may contain HEAT repeats.",".",".",".",".","."]
["ENSRNOG00000012098",151,12.53702574,94,6.047061189,2.073242745,1.051889044,{"v":1.6018e-08,"d":"1.60E-08"},{"v":2.95843e-08,"d":"2.96E-08"},"up","yes","Adcyap1r1","protein_coding","chr4:84593892-84642700:+","gi|537136769|gb|ERE66725.1|",2662,0,"pituitary adenylate cyclase-activating polypeptide type I receptor isoform 1 [Cricetulus griseus]","gi|396080322|ref|NM_001270579.1|",6316,0,"Rattus norvegicus adenylate cyclase activating polypeptide 1 receptor type 1 (Adcyap1r1), transcript variant 1, mRNA","P32215",1023,0,"Pituitary adenylate cyclase-activating polypeptide type I receptor",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0007166|cell surface receptor signaling pathway;GO:0007188|adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007202|activation of phospholipase C activity;GO:0007283|spermatogenesis;GO:0009410|response to xenobiotic stimulus;GO:0010524|positive regulation of calcium ion transport into cytosol;GO:0019933|cAMP-mediated signaling;GO:0030154|cell differentiation;GO:0032355|response to estradiol;GO:0033555|multicellular organismal response to stress;GO:0043950|positive regulation of cAMP-mediated signaling;GO:0045471|response to ethanol;GO:0046545|development of primary female sexual characteristics;GO:0051057|positive regulation of small GTPase mediated signal transduction;GO:0060548|negative regulation of cell death;GO:0060732|positive regulation of inositol phosphate biosynthetic process;","GO:0000139|Golgi membrane;GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005791|rough endoplasmic reticulum;GO:0005886|plasma membrane;GO:0005901|caveola;GO:0005923|bicellular tight junction;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0043005|neuron projection;GO:0043231|intracellular membrane-bounded organelle;GO:0043235|receptor complex;","GO:0001634|pituitary adenylate cyclase-activating polypeptide receptor activity;GO:0004999|vasoactive intestinal polypeptide receptor activity;GO:0008179|adenylate cyclase binding;GO:0008528|G protein-coupled peptide receptor activity;GO:0017046|peptide hormone binding;GO:0031267|small GTPase binding;GO:0042923|neuropeptide binding;","K04587","ADCYAP1R1, PACAPRI; pituitary adenylate cyclase-activating polypeptide type I receptor"]
["ENSRNOG00000070399",26,2.158693174,1,0.064330438,33.55632628,5.068512874,{"v":1.77679e-08,"d":"1.78E-08"},{"v":3.26841e-08,"d":"3.27E-08"},"up","yes","ENSRNOG00000070399","protein_coding","chr2:231643535-231741152:-","gi|564301078|ref|XP_003753729.2|",2638,0,"PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC685116 isoform X1 [Rattus norvegicus]","gi|672016482|ref|XM_008775292.1|",1300,0,"PREDICTED: Rattus norvegicus similar to guanylate binding protein family, member 6 (LOC687532), transcript variant X1, mRNA","Q61107",729,0,"Guanylate-binding protein 4",".",".",".",".","pfam02841","GBP_C","Guanylate-binding protein, C-terminal domain. Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.",".",".",".",".","."]
["ENSRNOG00000032429",52,4.317386347,15,0.964956573,4.474176838,2.161622279,{"v":1.88964e-08,"d":"1.89E-08"},{"v":3.47E-8,"d":"3.47E-08"},"up","yes","Tmprss9","protein_coding","chr7:8810320-8831177:-","gi|564358159|ref|XP_006240993.1|",5252,0,"PREDICTED: transmembrane protease serine 9 isoform X1 [Rattus norvegicus]","gi|564358158|ref|XM_006240931.1|",3455,0,"PREDICTED: Rattus norvegicus transmembrane protease, serine 9 (Tmprss9), transcript variant X1, mRNA","P69526",1943,0,"Transmembrane protease serine 9","VC1649",117,{"v":2e-26,"d":"2.00E-26"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;GO:0031639|plasminogen activation;","GO:0005887|integral component of plasma membrane;GO:0016020|membrane;","GO:0004252|serine-type endopeptidase activity;GO:0008236|serine-type peptidase activity;","K09640","TMPRSS9; transmembrane protease serine 9 [EC:3.4.21.-]"]
["ENSRNOG00000017083",28,2.324746495,2,0.128660876,18.06879108,4.175428078,{"v":1.89755E-8,"d":"1.90E-08"},{"v":3.48254e-08,"d":"3.48E-08"},"up","yes","Fam50b","protein_coding","chr17:30174411-30193615:-","gi|157824014|ref|NP_001100819.1|",1412,{"v":1E-179,"d":"1.00E-179"},"protein FAM50B [Rattus norvegicus]","gi|157824013|ref|NM_001107349.1|",1171,0,"Rattus norvegicus family with sequence similarity 50, member B (Fam50b), mRNA","Q9WTJ8",534,{"v":9E-176,"d":"9.00E-176"},"Protein FAM50B",".",".",".",".","pfam04921","XAP5","XAP5, circadian clock regulator. This protein is found in a wide range of eukaryotes. It is a nuclear protein and is suggested to be DNA binding. In plants, this family is essential for correct circadian clock functioning by acting as a light-quality regulator coordinating the activities of blue and red light signalling pathways during plant growth - inhibiting growth in red light but promoting growth in blue light.","GO:0006325|chromatin organization;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0030496|midbody;GO:0045171|intercellular bridge;",".","K13119","FAM50, XAP5; protein FAM50"]
["ENSRNOG00000002253",71,5.894892897,28,1.801252269,3.27266369,1.710465354,{"v":1.90169e-08,"d":"1.90E-08"},{"v":3.48712e-08,"d":"3.49E-08"},"up","yes","Wdr5b","protein_coding","chr11:64710355-64712807:-","gi|67078490|ref|NP_001019937.1|",1612,0,"WD repeat-containing protein 5B [Rattus norvegicus]","gi|67078489|ref|NM_001024766.1|",1860,0,"Rattus norvegicus WD repeat domain 5B (Wdr5b), mRNA","Q4V8C4",625,0,"WD repeat-containing protein 5B",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.","GO:0051568|histone H3-K4 methylation;","GO:0048188|Set1C/COMPASS complex;","GO:0005515|protein binding;GO:0042393|histone binding;","K14963","WDR5, SWD3, CPS30; COMPASS component SWD3"]
["ENSRNOG00000032375",30,2.490799816,3,0.192991315,12.90627934,3.690001251,{"v":2.22932e-08,"d":"2.23E-08"},{"v":4.06342e-08,"d":"4.06E-08"},"up","yes","Capn13","protein_coding","chr6:22071845-22166850:+","gi|68341951|ref|NP_001020304.1|",3523,0,"calpain-13 [Rattus norvegicus]","gi|68341950|ref|NM_001025133.1|",2573,0,"Rattus norvegicus calpain 13 (Capn13), mRNA","Q5BK10",1361,0,"Calpain-13",".",".",".",".","pfam00648","Peptidase_C2","Calpain family cysteine protease.","GO:0006508|proteolysis;GO:0043066|negative regulation of apoptotic process;","GO:0005737|cytoplasm;","GO:0004198|calcium-dependent cysteine-type endopeptidase activity;GO:0005509|calcium ion binding;","K08581","CAPN13; calpain-13 [EC:3.4.22.-]"]
["ENSRNOG00000021357",65,5.396732934,24,1.543930516,3.495450654,1.805478468,{"v":2.35029E-8,"d":"2.35E-08"},{"v":4.27782e-08,"d":"4.28E-08"},"up","yes","AC118772.2","protein_coding","chr10:68055355-68060603:+","gi|672025020|ref|XP_008773388.1|",2578,0,"PREDICTED: schlafen family member 12-like [Rattus norvegicus]","gi|672068330|ref|XM_008767933.1|",1227,0,"PREDICTED: Rattus norvegicus schlafen 3 (Slfn3), transcript variant X1, mRNA","Q8IYM2",427,{"v":7e-141,"d":"7.00E-141"},"Schlafen family member 12",".",".",".",".","pfam04326","AAA_4","Divergent AAA domain. This family is related to the pfam00004 family, and presumably has the same function (ATP-binding).",".",".",".",".","."]
["ENSRNOG00000022426",43,3.570146403,10,0.643304382,5.549700116,2.472409816,{"v":3.01358e-08,"d":"3.01E-08"},{"v":5.43253e-08,"d":"5.43E-08"},"up","yes","ENSRNOG00000022426","protein_coding","chr12:15229743-15242139:-","gi|564315040|ref|XP_006221342.1|",1571,0,"PREDICTED: uncharacterized protein LOC102546864 [Rattus norvegicus]","gi|672026549|ref|XM_008759032.1|",1675,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102546864 (LOC102546864), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam02628","COX15-CtaA","Cytochrome oxidase assembly protein. This is a family of integral membrane proteins. CtaA is required for cytochrome aa3 oxidase assembly in Bacillus subtilis. COX15 is required for cytochrome c oxidase assembly in yeast.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000009144",63,5.230679613,23,1.479600078,3.535198254,1.821791124,{"v":3.176e-08,"d":"3.18E-08"},{"v":5.71082e-08,"d":"5.71E-08"},"up","yes","Lad1","protein_coding","chr13:47249605-47263967:+","gi|189181736|ref|NP_001101412.2|",2332,0,"ladinin-1 [Rattus norvegicus]","gi|189181735|ref|NM_001107942.2|",2148,0,"Rattus norvegicus ladinin 1 (Lad1), mRNA","P57016",778,0,"Ladinin-1",".",".",".",".","pfam02029","Caldesmon","Caldesmon.",".","GO:0005576|extracellular region;GO:0005604|basement membrane;GO:0015629|actin cytoskeleton;","GO:0005198|structural molecule activity;",".","."]
["ENSRNOG00000067780",25,2.075666513,1,0.064330438,32.26569835,5.011929346,{"v":3.48353e-08,"d":"3.48E-08"},{"v":6.24622e-08,"d":"6.25E-08"},"up","yes","ENSRNOG00000067780","lncRNA","chr1:80724326-80747150:+",".",".",".",".","gi|672035472|ref|XR_590093.1|",1771,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103691054 (LOC103691054), ncRNA",".",".",".",".",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.",".",".",".",".","."]
["ENSRNOG00000001173",125,10.37833257,73,4.696121987,2.209979339,1.144032882,{"v":3.74156e-08,"d":"3.74E-08"},{"v":6.69388e-08,"d":"6.69E-08"},"up","yes","Cabp1","protein_coding","chr12:41378897-41448927:+","gi|880931737|ref|XP_012975240.1|",1058,{"v":7e-134,"d":"7.00E-134"},"PREDICTED: calcium-binding protein 1 [Mesocricetus auratus]","gi|76056876|ref|NM_133529.2|",1064,0,"Rattus norvegicus calcium binding protein 1 (Cabp1), transcript variant 1, mRNA","Q9JLK7",390,{"v":1E-127,"d":"1.00E-127"},"Calcium-binding protein 1","SPAC3A12.14",92,{"v":3e-20,"d":"3.00E-20"},"COG5126","pfam13499","EF-hand_7","EF-hand domain pair.","GO:0007601|visual perception;GO:0010651|negative regulation of cell communication by electrical coupling;GO:0042308|negative regulation of protein import into nucleus;GO:0048167|regulation of synaptic plasticity;GO:0098885|modification of postsynaptic actin cytoskeleton;GO:0099527|postsynapse to nucleus signaling pathway;GO:1901385|regulation of voltage-gated calcium channel activity;GO:1901386|negative regulation of voltage-gated calcium channel activity;GO:1905539|regulation of postsynapse to nucleus signaling pathway;","GO:0000139|Golgi membrane;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0009898|cytoplasmic side of plasma membrane;GO:0014069|postsynaptic density;GO:0030141|secretory granule;GO:0030424|axon;GO:0030425|dendrite;GO:0032991|protein-containing complex;GO:0043025|neuronal cell body;GO:0044280|subplasmalemmal coating;GO:0048471|perinuclear region of cytoplasm;GO:0098978|glutamatergic synapse;GO:0099573|glutamatergic postsynaptic density;","GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0008139|nuclear localization sequence binding;GO:0019904|protein domain specific binding;GO:0031800|type 3 metabotropic glutamate receptor binding;GO:0042802|identical protein binding;GO:0044325|ion channel binding;GO:0048306|calcium-dependent protein binding;","K23531","CABP1_2_4_5; calcium-binding protein 1/2/4/5"]
["ENSRNOG00000012262",71,5.894892897,29,1.865582707,3.159813218,1.659839281,{"v":3.74624e-08,"d":"3.75E-08"},{"v":6.70038e-08,"d":"6.70E-08"},"up","yes","Depdc7","protein_coding","chr3:91099835-91121124:-","gi|71361617|ref|NP_001025087.1|",2522,0,"DEP domain-containing protein 7 [Rattus norvegicus]","gi|71361616|ref|NM_001029916.1|",1588,0,"Rattus norvegicus DEP domain containing 7 (Depdc7), mRNA","Q4QR86",976,0,"DEP domain-containing protein 7",".",".",".",".","pfam00610","DEP","Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP). The DEP domain is responsible for mediating intracellular protein targeting and regulation of protein stability in the cell. The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit.","GO:0035556|intracellular signal transduction;",".",".",".","."]
["ENSRNOG00000018543",27,2.241719834,2,0.128660876,17.42347711,4.122960658,{"v":3.79313E-8,"d":"3.79E-08"},{"v":6.77477e-08,"d":"6.77E-08"},"up","yes","Atp4b","protein_coding","chr16:76144150-76153063:+","gi|31542161|ref|NP_036642.2|",1599,0,"potassium-transporting ATPase subunit beta [Rattus norvegicus]","gi|31542160|ref|NM_012510.2|",1484,0,"Rattus norvegicus ATPase H+/K+ transporting beta subunit (Atp4b), mRNA","P18598",620,0,"Potassium-transporting ATPase subunit beta",".",".",".",".","pfam00287","Na_K-ATPase","Sodium / potassium ATPase beta chain.","GO:0006883|cellular sodium ion homeostasis;GO:0007155|cell adhesion;GO:0010243|response to organonitrogen compound;GO:0030007|cellular potassium ion homeostasis;GO:0032496|response to lipopolysaccharide;GO:0036376|sodium ion export across plasma membrane;GO:0045851|pH reduction;GO:0050790|regulation of catalytic activity;GO:1990573|potassium ion import across plasma membrane;","GO:0005890|sodium:potassium-exchanging ATPase complex;GO:0016020|membrane;GO:0016324|apical plasma membrane;","GO:0001671|ATPase activator activity;GO:1901363|heterocyclic compound binding;","K01543","ATP4B; H+/K+-exchanging ATPase subunit beta [EC:7.2.2.19]"]
["ENSRNOG00000004498",39,3.23803976,8,0.514643505,6.291811178,2.653475375,{"v":4.06151e-08,"d":"4.06E-08"},{"v":7.2339e-08,"d":"7.23E-08"},"up","yes","Scin","protein_coding","chr6:57109403-57188242:-","gi|38454236|ref|NP_942043.1|",3611,0,"adseverin [Rattus norvegicus]","gi|672056016|ref|XM_008764644.1|",2578,0,"PREDICTED: Rattus norvegicus scinderin (Scin), transcript variant X1, mRNA","Q60604",1369,0,"Adseverin",".",".",".",".","pfam00626","Gelsolin","Gelsolin repeat.","GO:0007417|central nervous system development;GO:0008154|actin polymerization or depolymerization;GO:0008285|negative regulation of cell proliferation;GO:0030031|cell projection assembly;GO:0042989|sequestering of actin monomers;GO:0043065|positive regulation of apoptotic process;GO:0045654|positive regulation of megakaryocyte differentiation;GO:0051014|actin filament severing;GO:0051016|barbed-end actin filament capping;GO:0051127|positive regulation of actin nucleation;GO:0051693|actin filament capping;","GO:0002102|podosome;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005903|brush border;GO:0015629|actin cytoskeleton;GO:0030054|cell junction;GO:0032991|protein-containing complex;","GO:0005509|calcium ion binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0051015|actin filament binding;","K05768","GSN; gelsolin"]
["ENSRNOG00000006705",89,7.389372787,43,2.766208842,2.671299677,1.417541832,{"v":4.09139E-8,"d":"4.09E-08"},{"v":7.28104e-08,"d":"7.28E-08"},"up","yes","Mkks","protein_coding","chr3:124201877-124220162:-","gi|56605782|ref|NP_001008354.1|",3008,0,"mcKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin [Rattus norvegicus]","gi|558757399|ref|NM_001008353.2|",2953,0,"Rattus norvegicus McKusick-Kaufman syndrome (Mkks), mRNA","Q9JI70",1065,0,"McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin","MTH794",88.6,{"v":3e-17,"d":"3.00E-17"},"COG0459","pfam00118","Cpn60_TCP1","TCP-1/cpn60 chaperonin family. This family includes members from the HSP60 chaperone family and the TCP-1 (T-complex protein) family.","GO:0006457|protein folding;GO:0007286|spermatid development;GO:0007608|sensory perception of smell;GO:0008150|biological_process;GO:0010629|negative regulation of gene expression;GO:0014824|artery smooth muscle contraction;GO:0021756|striatum development;GO:0021766|hippocampus development;GO:0021987|cerebral cortex development;GO:0030837|negative regulation of actin filament polymerization;GO:0032502|developmental process;GO:0033210|leptin-mediated signaling pathway;GO:0034260|negative regulation of GTPase activity;GO:0035176|social behavior;GO:0038108|negative regulation of appetite by leptin-mediated signaling pathway;GO:0040018|positive regulation of multicellular organism growth;GO:0042311|vasodilation;GO:0044321|response to leptin;GO:0045444|fat cell differentiation;GO:0045494|photoreceptor cell maintenance;GO:0045776|negative regulation of blood pressure;GO:0046907|intracellular transport;GO:0048854|brain morphogenesis;GO:0050910|detection of mechanical stimulus involved in sensory perception of sound;GO:0051131|chaperone-mediated protein complex assembly;GO:0051216|cartilage development;GO:0051492|regulation of stress fiber assembly;GO:0060271|cilium assembly;GO:0060296|regulation of cilium beat frequency involved in ciliary motility;GO:0060324|face development;GO:1905515|non-motile cilium assembly;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0031514|motile cilium;GO:0036064|ciliary basal body;GO:1902636|kinociliary basal body;","GO:0003674|molecular_function;GO:0005524|ATP binding;GO:0051082|unfolded protein binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;","K09492","MKKS; McKusick-Kaufman syndrome protein"]
["ENSRNOG00000055408",138,11.45767915,85,5.468087246,2.09537241,1.067206677,{"v":4.61036e-08,"d":"4.61E-08"},{"v":8.16597e-08,"d":"8.17E-08"},"up","yes","Gcat","protein_coding","chr7:110595091-110601473:+","gi|149065959|gb|EDM15832.1|",2217,0,"glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase), isoform CRA_b [Rattus norvegicus]","gi|66730434|ref|NM_001024277.1|",1467,0,"Rattus norvegicus glycine C-acetyltransferase (Gcat), mRNA","O88986",824,0,"2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial",".",".",".",".","pfam00155","Aminotran_1_2","Aminotransferase class I and II.","GO:0006567|threonine catabolic process;GO:0008150|biological_process;GO:0009058|biosynthetic process;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005739|mitochondrion;GO:0016607|nuclear speck;","GO:0003674|molecular_function;GO:0008890|glycine C-acetyltransferase activity;GO:0016874|ligase activity;GO:0030170|pyridoxal phosphate binding;","K00639","kbl, GCAT; glycine C-acetyltransferase [EC:2.3.1.29]"]
["ENSRNOG00000035633",31,2.573826476,4,0.257321753,10.00236649,3.322269467,{"v":4.87374e-08,"d":"4.87E-08"},{"v":8.60861E-8,"d":"8.61E-08"},"up","yes","Mir142","miRNA","chr10:72557857-72557967:+",".",".",".",".","gi|982305356|ref|XM_015438367.1|",111,{"v":5e-50,"d":"5.00E-50"},"PREDICTED: Macaca fascicularis benzodiazepine receptor (peripheral) associated protein 1 (BZRAP1), transcript variant X21, mRNA",".",".",".",".",".",".",".",".","pfam02277","DBI_PRT","Phosphoribosyltransferase. This family of proteins represent the nicotinate-nucleotide- dimethylbenzimidazole phosphoribosyltransferase (NN:DBI PRT) enzymes involved in dimethylbenzimidazole synthesis. This function is essential to de novo cobalamin (vitamin B12) production in bacteria. Nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazole (DMB) phosphoribosyltransferase (CobT) from Salmonella enterica plays a central role in the synthesis of alpha-ribazole-5'-phosphate, an intermediate for the lower ligand of cobalamin.","GO:0036294|cellular response to decreased oxygen levels;GO:0071222|cellular response to lipopolysaccharide;GO:0071391|cellular response to estrogen stimulus;GO:1990830|cellular response to leukemia inhibitory factor;",".",".","K17022","MIR142; microRNA 142"]
["ENSRNOG00000067138",31,2.573826476,4,0.257321753,10.00236649,3.322269467,{"v":4.87374e-08,"d":"4.87E-08"},{"v":8.60861E-8,"d":"8.61E-08"},"up","yes","Tlr10","protein_coding","chr14:43406217-43413917:+","gi|564383756|ref|XP_006251064.1|",4139,0,"PREDICTED: toll-like receptor 10 isoform X1 [Rattus norvegicus]","gi|672076174|ref|XM_006251002.2|",2555,0,"PREDICTED: Rattus norvegicus toll-like receptor 10 (Tlr10), transcript variant X1, mRNA","Q9BXR5",1130,0,"Toll-like receptor 10",".",".",".",".","pfam01582","TIR","TIR domain. The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.",".",".",".",".","."]
["ENSRNOG00000015445",42,3.487119742,10,0.643304382,5.420637323,2.438462484,{"v":5.55642e-08,"d":"5.56E-08"},{"v":9.7659e-08,"d":"9.77E-08"},"up","yes","Mal","protein_coding","chr3:114864378-114888136:-","gi|6981178|ref|NP_036930.1|",656,{"v":8E-78,"d":"8.00E-78"},"myelin and lymphocyte protein [Rattus norvegicus]","gi|6981177|ref|NM_012798.1|",2237,0,"Rattus norvegicus mal, T-cell differentiation protein (Mal), mRNA","Q64349",257,{"v":3E-79,"d":"3.00E-79"},"Myelin and lymphocyte protein",".",".",".",".","pfam01284","MARVEL","Membrane-associating domain. MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.","GO:0002175|protein localization to paranode region of axon;GO:0006886|intracellular protein transport;GO:0042552|myelination;GO:0098737|protein insertion into plasma membrane;GO:1902043|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors;","GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0019898|extrinsic component of membrane;GO:0044853|plasma membrane raft;GO:0045121|membrane raft;GO:0120003|hinge region between urothelial plaques of apical plasma membrane;","GO:0019911|structural constituent of myelin sheath;",".","."]
["ENSRNOG00000007335",92,7.638452768,46,2.959200157,2.581255868,1.368073156,{"v":5.62774e-08,"d":"5.63E-08"},{"v":9.8831e-08,"d":"9.88E-08"},"up","yes","Ccl11","protein_coding","chr10:67028328-67032926:+","gi|11276089|ref|NP_062078.1|",409,{"v":3e-46,"d":"3.00E-46"},"eotaxin precursor [Rattus norvegicus]","gi|11276088|ref|NM_019205.1|",972,0,"Rattus norvegicus chemokine (C-C motif) ligand 11 (Ccl11), mRNA","P97545",162,{"v":9e-48,"d":"9.00E-48"},"Eotaxin",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0001938|positive regulation of endothelial cell proliferation;GO:0002544|chronic inflammatory response;GO:0002548|monocyte chemotaxis;GO:0002551|mast cell chemotaxis;GO:0006954|inflammatory response;GO:0007010|cytoskeleton organization;GO:0007015|actin filament organization;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007611|learning or memory;GO:0008360|regulation of cell shape;GO:0030335|positive regulation of cell migration;GO:0030593|neutrophil chemotaxis;GO:0030838|positive regulation of actin filament polymerization;GO:0031640|killing of cells of other organism;GO:0035962|response to interleukin-13;GO:0043547|positive regulation of GTPase activity;GO:0045766|positive regulation of angiogenesis;GO:0048245|eosinophil chemotaxis;GO:0048247|lymphocyte chemotaxis;GO:0050768|negative regulation of neurogenesis;GO:0060444|branching involved in mammary gland duct morphogenesis;GO:0060763|mammary duct terminal end bud growth;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098|chemokine-mediated signaling pathway;GO:0070371|ERK1 and ERK2 cascade;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070670|response to interleukin-4;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0090647|modulation of age-related behavioral decline;","GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0008009|chemokine activity;GO:0031728|CCR3 chemokine receptor binding;GO:0046983|protein dimerization activity;GO:0048018|receptor ligand activity;GO:0048020|CCR chemokine receptor binding;","K16597","CCL11; C-C motif chemokine 11"]
["ENSRNOG00000011497",59,4.898572971,21,1.350939202,3.62604991,1.858398783,{"v":5.7631e-08,"d":"5.76E-08"},{"v":1.01097E-7,"d":"1.01E-07"},"up","yes","Aldh1b1","protein_coding","chr5:60063225-60068378:+","gi|149045822|gb|EDL98822.1|",2631,0,"rCG55098 [Rattus norvegicus]","gi|58865517|ref|NM_001011975.1|",2194,0,"Rattus norvegicus aldehyde dehydrogenase 1 family, member B1 (Aldh1b1), mRNA","Q66HF8",1015,0,"Aldehyde dehydrogenase X, mitochondrial","SPAC9E9.09c",499,{"v":1E-167,"d":"1.00E-167"},"COG1012","pfam00171","Aldedh","Aldehyde dehydrogenase family. This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:1.2.1.3. Succinate-semialdehyde dehydrogenase EC:1.2.1.16. Lactaldehyde dehydrogenase EC:1.2.1.22. Benzaldehyde dehydrogenase EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase EC: 1.5.1.12. Acetaldehyde dehydrogenase EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase EC:1.2.1.41. This family also includes omega crystallin, an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.","GO:0006068|ethanol catabolic process;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005739|mitochondrion;GO:0005759|mitochondrial matrix;GO:0005829|cytosol;GO:0043231|intracellular membrane-bounded organelle;","GO:0003674|molecular_function;GO:0004029|aldehyde dehydrogenase (NAD) activity;GO:0016620|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor;GO:0043878|glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity;","K00128","ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]"]
["ENSRNOG00000019216",118,9.797145942,68,4.374469797,2.239619062,1.163253364,{"v":6.02402E-8,"d":"6.02E-08"},{"v":1.05443E-7,"d":"1.05E-07"},"up","yes","Il12rb1","protein_coding","chr16:18620770-18632769:-","gi|282158059|ref|NP_001164075.1|",3934,0,"interleukin-12 receptor subunit beta-1 precursor [Rattus norvegicus]","gi|672079512|ref|XM_006252821.2|",2217,0,"PREDICTED: Rattus norvegicus interleukin 12 receptor, beta 1 (Il12rb1), transcript variant X1, mRNA","Q60837",1256,0,"Interleukin-12 receptor subunit beta-1",".",".",".",".","pfam00041","fn3","Fibronectin type III domain.","GO:0002230|positive regulation of defense response to virus by host;GO:0002827|positive regulation of T-helper 1 type immune response;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0019221|cytokine-mediated signaling pathway;GO:0032729|positive regulation of interferon-gamma production;GO:0035722|interleukin-12-mediated signaling pathway;GO:0038155|interleukin-23-mediated signaling pathway;GO:0042104|positive regulation of activated T cell proliferation;GO:0071346|cellular response to interferon-gamma;","GO:0009897|external side of plasma membrane;GO:0042022|interleukin-12 receptor complex;GO:0043235|receptor complex;GO:0072536|interleukin-23 receptor complex;","GO:0004896|cytokine receptor activity;GO:0005143|interleukin-12 receptor binding;GO:0016517|interleukin-12 receptor activity;GO:0019955|cytokine binding;GO:0042019|interleukin-23 binding;GO:0042020|interleukin-23 receptor activity;","K05063","IL12RB1, CD212; interleukin 12 receptor beta-1"]
["ENSRNOG00000049422",135,11.20859917,83,5.339426369,2.099214109,1.069849322,{"v":6.06458e-08,"d":"6.06E-08"},{"v":1.06124E-7,"d":"1.06E-07"},"up","yes","Fcgr2a","protein_coding","chr13:83280784-83295967:-","gi|31542804|ref|NP_446295.2|",1383,0,"low affinity immunoglobulin gamma Fc region receptor III [Rattus norvegicus]","gi|672074740|ref|XM_006250303.2|",1593,0,"PREDICTED: Rattus norvegicus Fc fragment of IgG, low affinity IIa, receptor (Fcgr2a), transcript variant X1, mRNA","P27645",473,{"v":7e-164,"d":"7.00E-164"},"Low affinity immunoglobulin gamma Fc region receptor III",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0001788|antibody-dependent cellular cytotoxicity;GO:0001798|positive regulation of type IIa hypersensitivity;GO:0001805|positive regulation of type III hypersensitivity;GO:0001812|positive regulation of type I hypersensitivity;GO:0001813|regulation of antibody-dependent cellular cytotoxicity;GO:0001820|serotonin secretion;GO:0006910|phagocytosis, recognition;GO:0006911|phagocytosis, engulfment;GO:0007166|cell surface receptor signaling pathway;GO:0021675|nerve development;GO:0030593|neutrophil chemotaxis;GO:0032680|regulation of tumor necrosis factor production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0038094|Fc-gamma receptor signaling pathway;GO:0042590|antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:0045576|mast cell activation;GO:0050766|positive regulation of phagocytosis;GO:0050776|regulation of immune response;GO:1905449|regulation of Fc-gamma receptor signaling pathway involved in phagocytosis;","GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0004888|transmembrane signaling receptor activity;GO:0019770|IgG receptor activity;GO:0019864|IgG binding;GO:0034987|immunoglobulin receptor binding;","K06463","FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III"]
["ENSRNOG00000042182",74,6.143972879,32,2.058574022,2.984577097,1.577526522,{"v":6.10888e-08,"d":"6.11E-08"},{"v":1.0687E-7,"d":"1.07E-07"},"up","yes","Mroh2a","protein_coding","chr9:88814197-88852607:+","gi|527317377|ref|NP_001268395.1|",8514,0,"maestro heat-like repeat-containing protein family member 2A [Mus musculus]","gi|672024279|ref|XR_349196.2|",6663,0,"PREDICTED: Rattus norvegicus maestro heat-like repeat family member 2A (Mroh2a), transcript variant X1, misc_RNA",".",".",".",".",".",".",".",".","pfam15240","Pro-rich","Proline-rich. This family includes several eukaryotic proline-rich proteins.",".",".",".",".","."]
["ENSRNOG00000014226",40,3.321066421,9,0.578973944,5.736124151,2.52007625,{"v":6.58677e-08,"d":"6.59E-08"},{"v":1.14884E-7,"d":"1.15E-07"},"up","yes","Plch2","protein_coding","chr5:165544200-165602356:-","gi|568931391|ref|XP_006538999.1|",7036,0,"PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X2 [Mus musculus]","gi|294862234|ref|NM_175556.4|",4394,0,"Mus musculus phospholipase C, eta 2 (Plch2), transcript variant 1, mRNA","A2AP18",1886,0,"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2",".",".",".",".","pfam00388","PI-PLC-X","Phosphatidylinositol-specific phospholipase C, X domain. This associates with pfam00387 to form a single structural unit.","GO:0016042|lipid catabolic process;GO:0046488|phosphatidylinositol metabolic process;GO:0048015|phosphatidylinositol-mediated signaling;","GO:0005886|plasma membrane;","GO:0004435|phosphatidylinositol phospholipase C activity;GO:0004629|phospholipase C activity;GO:0005509|calcium ion binding;","K19006","PLCH; phosphatidylinositol phospholipase C, eta [EC:3.1.4.11]"]
["ENSRNOG00000059456",40,3.321066421,9,0.578973944,5.736124151,2.52007625,{"v":6.58677e-08,"d":"6.59E-08"},{"v":1.14884E-7,"d":"1.15E-07"},"up","yes","Grk3","protein_coding","chr12:43624897-43731262:+","gi|6978467|ref|NP_037029.1|",3636,0,"beta-adrenergic receptor kinase 2 [Rattus norvegicus]","gi|145046260|ref|NM_012897.2|",2352,0,"Rattus norvegicus adrenergic, beta, receptor kinase 2 (Adrbk2), mRNA","P26819",1405,0,"Beta-adrenergic receptor kinase 2",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0001934|positive regulation of protein phosphorylation;GO:0002029|desensitization of G protein-coupled receptor signaling pathway;GO:0006468|protein phosphorylation;GO:0006886|intracellular protein transport;GO:0007165|signal transduction;GO:0007186|G protein-coupled receptor signaling pathway;GO:0009966|regulation of signal transduction;GO:0010259|multicellular organism aging;GO:0031623|receptor internalization;GO:0043278|response to morphine;GO:0043647|inositol phosphate metabolic process;GO:0045744|negative regulation of G protein-coupled receptor signaling pathway;GO:0046154|rhodopsin metabolic process;","GO:0005634|nucleus;GO:0005829|cytosol;GO:0005929|cilium;GO:0016020|membrane;GO:0030018|Z disc;GO:0030424|axon;GO:0043197|dendritic spine;GO:0043198|dendritic shaft;GO:0044292|dendrite terminus;GO:0045121|membrane raft;GO:0045202|synapse;GO:0048471|perinuclear region of cytoplasm;GO:0097225|sperm midpiece;","GO:0001664|G protein-coupled receptor binding;GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0004703|G protein-coupled receptor kinase activity;GO:0005524|ATP binding;GO:0031748|D1 dopamine receptor binding;GO:0047696|beta-adrenergic receptor kinase activity;","K00910","ADRBK, GRK; beta-adrenergic-receptor kinase [EC:2.7.11.15]"]
["ENSRNOG00000068008",40,3.321066421,9,0.578973944,5.736124151,2.52007625,{"v":6.58677e-08,"d":"6.59E-08"},{"v":1.14884E-7,"d":"1.15E-07"},"up","yes","ENSRNOG00000068008","lncRNA","chr6:124365829-124398449:+","gi|564357199|ref|XP_006240598.1|",810,{"v":6e-95,"d":"6.00E-95"},"PREDICTED: putative uncharacterized protein C14orf132 homolog [Rattus norvegicus]","gi|672057098|ref|XM_006240536.2|",2055,0,"PREDICTED: Rattus norvegicus uncharacterized LOC100909954 (LOC100909954), mRNA","Q9NPU4",120,{"v":2e-29,"d":"2.00E-29"},"Uncharacterized protein C14orf132",".",".",".",".","pfam15498","Dendrin","Nephrin and CD2AP-binding protein, Dendrin. Dendrin is a family of eukaryotic proteins found in the podocytes of the kidneys. Dendrin, originally identified in telencephalic dendrites, is a constituent of the slit diaphragm, SD, complex of podocytes, where it directly binds to nephrin and CD2AP. Kidney podocytes and their slit diaphragms (SDs) form the final barrier to urinary protein loss. SD proteins also participate in intracellular signalling pathways. Dendrin appears to prevent programmed cell death (apoptosis) through its binding to nephrin. The SD protein nephrin serves as a component of a signalling complex that directly links podocyte junctional integrity to actin cytoskeletal dynamics. Thus, dendrin is identified as an SD family with proapoptotic signalling properties that accumulates in the podocyte nucleus in response to glomerular injury.",".",".",".",".","."]
["ENSRNOG00000037148",138,11.45767915,86,5.532417684,2.071007615,1.050332858,{"v":6.85042E-8,"d":"6.85E-08"},{"v":1.19287E-7,"d":"1.19E-07"},"up","yes","Adap2","protein_coding","chr10:65138020-65165604:+","gi|880920145|ref|XP_005077039.2|",1804,0,"PREDICTED: arf-GAP with dual PH domain-containing protein 2 isoform X1 [Mesocricetus auratus]","gi|9910339|ref|NM_020101.1|",1640,0,"Rattus norvegicus ArfGAP with dual PH domains 2 (Adap2), mRNA","Q9JK15",696,0,"Arf-GAP with dual PH domain-containing protein 2","SPBC21D10.05c",71.2,{"v":5e-12,"d":"5.00E-12"},"COG5347","pfam01412","ArfGap","Putative GTPase activating protein for Arf. Putative zinc fingers with GTPase activating proteins (GAPs) towards the small GTPase, Arf. The GAP of ARD1 stimulates GTPase hydrolysis for ARD1 but not ARFs.","GO:0007507|heart development;GO:0043547|positive regulation of GTPase activity;GO:0048017|inositol lipid-mediated signaling;","GO:0005737|cytoplasm;GO:0005740|mitochondrial envelope;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0005096|GTPase activator activity;GO:0005545|1-phosphatidylinositol binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;GO:0043325|phosphatidylinositol-3,4-bisphosphate binding;GO:0043533|inositol 1,3,4,5 tetrakisphosphate binding;GO:0046872|metal ion binding;GO:1902936|phosphatidylinositol bisphosphate binding;","K23781","ADAP, CENTA; Arf-GAP with dual PH domain-containing protein"]
["ENSRNOG00000054033",101,8.385692713,54,3.473843662,2.413952247,1.271397137,{"v":7.57704e-08,"d":"7.58E-08"},{"v":1.31368e-07,"d":"1.31E-07"},"up","yes","Adap1","protein_coding","chr12:15324209-15380831:+","gi|19424252|ref|NP_598251.1|",1898,0,"arf-GAP with dual PH domain-containing protein 1 [Rattus norvegicus]","gi|76496483|ref|NM_133567.2|",2196,0,"Rattus norvegicus ArfGAP with dual PH domains 1 (Adap1), mRNA","O75689",698,0,"Arf-GAP with dual PH domain-containing protein 1","SPAC824.09c",71.2,{"v":2E-12,"d":"2.00E-12"},"COG5347","pfam01412","ArfGap","Putative GTPase activating protein for Arf. Putative zinc fingers with GTPase activating proteins (GAPs) towards the small GTPase, Arf. The GAP of ARD1 stimulates GTPase hydrolysis for ARD1 but not ARFs.","GO:0043087|regulation of GTPase activity;GO:0043547|positive regulation of GTPase activity;GO:0048016|inositol phosphate-mediated signaling;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0005096|GTPase activator activity;GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;GO:1902936|phosphatidylinositol bisphosphate binding;","K23781","ADAP, CENTA; Arf-GAP with dual PH domain-containing protein"]
["ENSRNOG00000065100",26,2.158693174,2,0.128660876,16.77816314,4.068512874,{"v":7.58983e-08,"d":"7.59E-08"},{"v":1.31518E-7,"d":"1.32E-07"},"up","yes","ENSRNOG00000065100","protein_coding","chr15:33425586-33442327:-","gi|62079205|ref|NP_001014257.1|",1269,{"v":2E-171,"d":"2.00E-171"},"PHD finger protein 11-like [Rattus norvegicus]","gi|62079204|ref|NM_001014235.1|",1095,0,"Rattus norvegicus PHD finger protein 11B (Phf11b), mRNA","Q5I0J8",493,{"v":6e-173,"d":"6.00E-173"},"PHD finger protein 11-like",".",".",".",".","pfam13771","zf-HC5HC2H","PHD-like zinc-binding domain. The members of this family are annotated as containing PHD domain, but the zinc-binding region here is not typical of PHD domains. The conformation here is a well-conserved cysteine-histidine rich region spanning 90 residues, where the Cys and His are arranged as HxxC(31)CxxC(6)CxxCxxxxCxxxxHxxC (21)CxxH.",".",".",".",".","."]
["ENSRNOG00000013902",48,3.985279705,14,0.900626135,4.425010059,2.145680735,{"v":7.60487e-08,"d":"7.60E-08"},{"v":1.31743e-07,"d":"1.32E-07"},"up","yes","P2ry12","protein_coding","chr2:143481430-143523361:-","gi|12248187|ref|NP_073637.1|",1689,0,"P2Y purinoceptor 12 [Rattus norvegicus]","gi|672042396|ref|XM_006232408.2|",2092,0,"PREDICTED: Rattus norvegicus purinergic receptor P2Y, G-protein coupled, 12 (P2ry12), transcript variant X3, mRNA","Q9EPX4",655,0,"P2Y purinoceptor 12",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001973|adenosine receptor signaling pathway;GO:0006930|substrate-dependent cell migration, cell extension;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007188|adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007193|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0008347|glial cell migration;GO:0010700|negative regulation of norepinephrine secretion;GO:0019722|calcium-mediated signaling;GO:0021808|cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration;GO:0030030|cell projection organization;GO:0030032|lamellipodium assembly;GO:0030168|platelet activation;GO:0033626|positive regulation of integrin activation by cell surface receptor linked signal transduction;GO:0033630|positive regulation of cell adhesion mediated by integrin;GO:0035585|calcium-mediated signaling using extracellular calcium source;GO:0035589|G protein-coupled purinergic nucleotide receptor signaling pathway;GO:0043270|positive regulation of ion transport;GO:0043491|protein kinase B signaling;GO:0045596|negative regulation of cell differentiation;GO:0048678|response to axon injury;GO:0050920|regulation of chemotaxis;GO:0050921|positive regulation of chemotaxis;GO:0051897|positive regulation of protein kinase B signaling;GO:0051924|regulation of calcium ion transport;GO:0070527|platelet aggregation;GO:0070588|calcium ion transmembrane transport;GO:0071318|cellular response to ATP;GO:0071407|cellular response to organic cyclic compound;GO:0071805|potassium ion transmembrane transport;GO:0150063|visual system development;GO:1900029|positive regulation of ruffle assembly;GO:1904139|regulation of microglial cell migration;GO:1904141|positive regulation of microglial cell migration;","GO:0005739|mitochondrion;GO:0005886|plasma membrane;GO:0005901|caveola;GO:0009897|external side of plasma membrane;GO:0009925|basal plasma membrane;GO:0016021|integral component of membrane;GO:0031224|intrinsic component of membrane;GO:0031253|cell projection membrane;GO:0044298|cell body membrane;","GO:0001609|G protein-coupled adenosine receptor activity;GO:0001621|ADP receptor activity;GO:0045028|G protein-coupled purinergic nucleotide receptor activity;","K04298","P2RY12; P2Y purinoceptor 12"]
["ENSRNOG00000060193",85,7.057266145,41,2.637547966,2.675692058,1.419912088,{"v":7.9217e-08,"d":"7.92E-08"},{"v":1.37009e-07,"d":"1.37E-07"},"up","yes","Prr29","protein_coding","chr10:91305723-91310439:+","gi|34873950|ref|XP_213490.2|",824,{"v":2E-99,"d":"2.00E-99"},"PREDICTED: proline-rich protein 29 [Rattus norvegicus]","gi|672069923|ref|XM_213490.8|",1501,0,"PREDICTED: Rattus norvegicus proline rich 29 (Prr29), mRNA",".",".",".",".",".",".",".",".","pfam15248","DUF4587","Domain of unknown function (DUF4587). This protein family is a domain of unknown function. The precise function of this protein domain remains to be elucidated. This domain family is found in eukaryotes, and is typically between 64 and 79 amino acids in length. There are two conserved sequence motifs: QNAQ and HHH. In humans, it is found in the position, chromosome 21 open reading frame 58.",".",".",".",".","."]
["ENSRNOG00000003136",54,4.483439668,18,1.157947887,3.871883802,1.953035657,{"v":8.02321e-08,"d":"8.02E-08"},{"v":1.38652e-07,"d":"1.39E-07"},"up","yes","Fcrla","protein_coding","chr13:83160398-83170762:-","gi|209915619|ref|NP_001094152.1|",1566,0,"Fc receptor-like A precursor [Rattus norvegicus]","gi|77748042|gb|BC105902.1|",1155,0,"Rattus norvegicus Fc receptor-like A, mRNA (cDNA clone IMAGE:7376173), partial cds","Q3B8P2",607,0,"Fc receptor-like A",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0007166|cell surface receptor signaling pathway;GO:0030154|cell differentiation;","GO:0005737|cytoplasm;GO:0005887|integral component of plasma membrane;","GO:0004888|transmembrane signaling receptor activity;",".","."]
["ENSRNOG00000064760",76,6.3100262,34,2.187234898,2.884933029,1.528537828,{"v":8.17682e-08,"d":"8.18E-08"},{"v":1.41192e-07,"d":"1.41E-07"},"up","yes","ENSRNOG00000064760","lncRNA","chr9:109308360-109321450:-","gi|149036268|gb|EDL90927.1|",285,{"v":1E-27,"d":"1.00E-27"},"rCG35633 [Rattus norvegicus]","gi|672024416|ref|XR_589357.1|",1558,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102552880 (LOC102552880), ncRNA",".",".",".",".",".",".",".",".","pfam11819","DUF3338","Domain of unknown function (DUF3338). This family of proteins are functionally uncharacterized. This family is found in eukaryotes. This presumed domain is about 130 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000047714",86,7.140292805,42,2.701878404,2.642714341,1.402020488,{"v":8.84889E-8,"d":"8.85E-08"},{"v":1.51976e-07,"d":"1.52E-07"},"up","yes","Tmem37","protein_coding","chr13:31171355-31191077:-","gi|672073629|ref|XP_008767646.1|",1089,{"v":9e-145,"d":"9.00E-145"},"PREDICTED: voltage-dependent calcium channel gamma-like subunit isoform X1 [Rattus norvegicus]","gi|672073628|ref|XM_008769424.1|",1178,0,"PREDICTED: Rattus norvegicus transmembrane protein 37 (Tmem37), transcript variant X1, mRNA","Q8VHW1",390,{"v":2e-133,"d":"2.00E-133"},"Voltage-dependent calcium channel gamma-like subunit",".",".",".",".","pfam15108","TMEM37","Voltage-dependent calcium channel gamma-like subunit protein family. This family of transmembrane proteins, TMEM37, has a role in stabilizing the calcium channel in an inactivated (closed) state. It is a subunit of the L-type calcium channels. This family of proteins are found in eukaryotes. Proteins in this family are approximately 210 amino acids in length.","GO:0034765|regulation of ion transmembrane transport;GO:0070588|calcium ion transmembrane transport;","GO:0016021|integral component of membrane;","GO:0005244|voltage-gated ion channel activity;GO:0005262|calcium channel activity;",".","."]
["ENSRNOG00000018962",146,12.12189244,94,6.047061189,2.004592323,1.003308863,{"v":9.08391e-08,"d":"9.08E-08"},{"v":1.55595e-07,"d":"1.56E-07"},"up","yes","Ctf1","protein_coding","chr1:182328090-182333335:+","gi|149067691|gb|EDM17243.1|",864,{"v":5E-110,"d":"5.00E-110"},"cardiotrophin 1, isoform CRA_a [Rattus norvegicus]","gi|8393211|ref|NM_017129.1|",1339,0,"Rattus norvegicus cardiotrophin 1 (Ctf1), mRNA","Q63086",335,{"v":9e-111,"d":"9.00E-111"},"Cardiotrophin-1",".",".",".",".","pfam06875","PRF","Plethodontid receptivity factor PRF. This family consists of several plethodontid receptivity factor (PRF) proteins which seem to be specific to Plethodon jordani (Jordan's salamander). PRF is a courtship pheromone produced by males increase female receptivity.","GO:0006955|immune response;GO:0007166|cell surface receptor signaling pathway;GO:0007399|nervous system development;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0048666|neuron development;GO:0048861|leukemia inhibitory factor signaling pathway;","GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0005125|cytokine activity;GO:0005146|leukemia inhibitory factor receptor binding;","K05422","CTF1, CT1; cardiotrophin 1"]
["ENSRNOG00000011181",23,1.909613192,0,0.032165219,59.36888496,5.891635112,{"v":9.33156e-08,"d":"9.33E-08"},{"v":1.59537e-07,"d":"1.60E-07"},"up","yes","Cpa3","protein_coding","chr2:102712589-102744203:-","gi|213512704|ref|NP_062173.1|",2256,0,"mast cell carboxypeptidase A precursor [Rattus norvegicus]","gi|213512703|ref|NM_019300.1|",1427,0,"Rattus norvegicus carboxypeptidase A3 (Cpa3), mRNA","P21961",863,0,"Mast cell carboxypeptidase A (Fragment)","YHR132c",186,{"v":5E-52,"d":"5.00E-52"},"COG2866","pfam00246","Peptidase_M14","Zinc carboxypeptidase.","GO:0002002|regulation of angiotensin levels in blood;GO:0006508|proteolysis;","GO:0005615|extracellular space;GO:0030133|transport vesicle;","GO:0004181|metallocarboxypeptidase activity;GO:0008233|peptidase activity;GO:0008270|zinc ion binding;","K08780","CPA3; carboxypeptidase A3 [EC:3.4.17.1]"]
["ENSRNOG00000069762",34,2.822906458,6,0.385982629,7.313558292,2.870573497,{"v":9.35304E-8,"d":"9.35E-08"},{"v":1.59862e-07,"d":"1.60E-07"},"up","yes","MGC93861","protein_coding","chr1:240857263-240867394:+","gi|112983998|ref|NP_001037746.1|",1066,{"v":3e-129,"d":"3.00E-129"},"uncharacterized protein C10orf62 homolog [Rattus norvegicus]","gi|30315691|gb|AC131867.4|",4576,0,"Rattus norvegicus 1 BAC CH230-397C2 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam12852","Cupin_6","Cupin. This is a family of bacterial and eukaryotic proteins that belong to the Cupin superfamily. Some of the proteins in this family are annotated as being members of the AraC family of transcription factors, in which case this domain corresponds to the ligand binding domain.",".",".",".",".","."]
["ENSRNOG00000036649",138,11.45767915,87,5.596748122,2.04720293,1.033654117,{"v":1.01093E-7,"d":"1.01E-07"},{"v":1.72144e-07,"d":"1.72E-07"},"up","yes","Pwwp2b","protein_coding","chr1:194041341-194059958:+","gi|564331527|ref|XP_006230528.1|",2634,0,"PREDICTED: PWWP domain-containing protein 2B isoform X1 [Rattus norvegicus]","gi|672038909|ref|XM_006230466.2|",2530,0,"PREDICTED: Rattus norvegicus PWWP domain containing 2B (Pwwp2b), transcript variant X1, mRNA","Q6NUJ5",707,0,"PWWP domain-containing protein 2B",".",".",".",".","pfam00855","PWWP","PWWP domain. The PWWP domain is named after a conserved Pro-Trp-Trp-Pro motif. The domain binds to Histone-4 methylated at lysine-20, H4K20me, suggesting that it is methyl-lysine recognition motif. Removal of two conserved aromatic residues in a hydrophobic cavity created by this domain within the full-length protein, Pdp1, abolishes the interaction o f the protein with H4K20me3. In fission yeast, Set9 is the sole enzyme that catalyses all three states of H4K20me, and Set9-mediated H4K20me is required for efficient recruitment of checkpoint protein Crb2 to sites of DNA damage. The methylation of H4K20 is involved in a diverse array of cellular processes, such as organizing higher-order chromatin, maintaining genome stability, and regulating cell-cycle progression.",".","GO:0005654|nucleoplasm;",".",".","."]
["ENSRNOG00000010248",55,4.566466329,19,1.222278326,3.73602823,1.901505356,{"v":1.03502E-7,"d":"1.04E-07"},{"v":1.76058E-7,"d":"1.76E-07"},"up","yes","Serpini1","protein_coding","chr2:160346758-160433135:+","gi|16758618|ref|NP_446231.1|",2102,0,"neuroserpin precursor [Rattus norvegicus]","gi|16758617|ref|NM_053779.1|",2886,0,"Rattus norvegicus serpin peptidase inhibitor, clade I (neuroserpin), member 1 (Serpini1), mRNA","Q9JLD2",814,0,"Neuroserpin","all0778",184,{"v":5e-50,"d":"5.00E-50"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0010951|negative regulation of endopeptidase activity;GO:0010976|positive regulation of neuron projection development;GO:0030155|regulation of cell adhesion;","GO:0005615|extracellular space;GO:0034774|secretory granule lumen;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0060205|cytoplasmic vesicle lumen;","GO:0004867|serine-type endopeptidase inhibitor activity;","K23412","SERPINI1; neuroserpin"]
["ENSRNOG00000002396",62,5.147652953,24,1.543930516,3.334122163,1.737306966,{"v":1.09582e-07,"d":"1.10E-07"},{"v":1.85906E-7,"d":"1.86E-07"},"up","yes","Serpinb8","protein_coding","chr13:23626945-23650835:+","gi|157786978|ref|NP_001099418.1|",1920,0,"serpin B8 [Rattus norvegicus]","gi|157786977|ref|NM_001105948.1|",2468,0,"Rattus norvegicus serpin peptidase inhibitor, clade B (ovalbumin), member 8 (Serpinb8), mRNA","O08800",681,0,"Serpin B8","MA2246",181,{"v":1e-48,"d":"1.00E-48"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0008150|biological_process;GO:0010951|negative regulation of endopeptidase activity;GO:0090136|epithelial cell-cell adhesion;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0003674|molecular_function;GO:0004867|serine-type endopeptidase inhibitor activity;","K13965","SERPINB8; serpin B8"]
["ENSRNOG00000024000",79,6.559106181,37,2.380226213,2.755665048,1.462400539,{"v":1.21171e-07,"d":"1.21E-07"},{"v":2.04212E-7,"d":"2.04E-07"},"up","yes","Cd22","protein_coding","chr1:86117459-86132322:-","gi|157819397|ref|NP_001100973.1|",4489,0,"B-cell receptor CD22 precursor [Rattus norvegicus]","gi|157819396|ref|NM_001107503.1|",3690,0,"Rattus norvegicus CD22 molecule (Cd22), mRNA","P35329",1345,0,"B-cell receptor CD22",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0002638|negative regulation of immunoglobulin production;GO:0030100|regulation of endocytosis;GO:0030888|regulation of B cell proliferation;GO:0042113|B cell activation;GO:0050776|regulation of immune response;GO:0050849|negative regulation of calcium-mediated signaling;GO:0050859|negative regulation of B cell receptor signaling pathway;","GO:0005769|early endosome;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0032809|neuronal cell body membrane;GO:0055037|recycling endosome;","GO:0019903|protein phosphatase binding;GO:0033691|sialic acid binding;GO:0042609|CD4 receptor binding;","K06467","CD22, SIGLEC2; CD22 antigen"]
["ENSRNOG00000008922",59,4.898572971,22,1.41526964,3.461229459,1.791284587,{"v":1.21499e-07,"d":"1.21E-07"},{"v":2.04711e-07,"d":"2.05E-07"},"up","yes","Trim14","protein_coding","chr5:60800032-60824858:-","gi|157817684|ref|NP_001101404.1|",1863,0,"tripartite motif-containing protein 14 [Rattus norvegicus]","gi|157817683|ref|NM_001107934.1|",3446,0,"Rattus norvegicus tripartite motif-containing 14 (Trim14), mRNA","Q8BVW3",598,0,"Tripartite motif-containing protein 14",".",".",".",".","pfam00622","SPRY","SPRY domain. SPRY Domain is named from SPla and the RYanodine Receptor. Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.","GO:0000209|protein polyubiquitination;GO:0008150|biological_process;GO:0010468|regulation of gene expression;GO:0010508|positive regulation of autophagy;GO:0016567|protein ubiquitination;GO:0032880|regulation of protein localization;GO:0032897|negative regulation of viral transcription;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045087|innate immune response;GO:0045893|positive regulation of transcription, DNA-templated;GO:0046596|regulation of viral entry into host cell;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051092|positive regulation of NF-kappaB transcription factor activity;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0003674|molecular_function;GO:0003713|transcription coactivator activity;GO:0008270|zinc ion binding;GO:0019901|protein kinase binding;GO:0042803|protein homodimerization activity;GO:0061630|ubiquitin protein ligase activity;","K12004","TRIM14; tripartite motif-containing protein 14"]
["ENSRNOG00000014452",95,7.88753275,50,3.216521909,2.452193075,1.294072575,{"v":1.24369e-07,"d":"1.24E-07"},{"v":2.09161E-7,"d":"2.09E-07"},"up","yes","Zfhx3","protein_coding","chr19:36630254-36881771:+","gi|672085073|ref|XP_008770789.1|",13553,0,"PREDICTED: zinc finger homeobox protein 3 isoform X2 [Rattus norvegicus]","gi|672085072|ref|XM_008772567.1|",11296,0,"PREDICTED: Rattus norvegicus zinc finger homeobox 3 (Zfhx3), transcript variant X2, mRNA","Q61329",5062,0,"Zinc finger homeobox protein 3","ECU06g0500",55.1,3e-07,"COG5576","pfam00046","Homeobox","Homeobox domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007420|brain development;GO:0032922|circadian regulation of gene expression;GO:0045662|negative regulation of myoblast differentiation;GO:0045663|positive regulation of myoblast differentiation;GO:0045664|regulation of neuron differentiation;GO:0045785|positive regulation of cell adhesion;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051726|regulation of cell cycle;GO:0071559|response to transforming growth factor beta;GO:1904059|regulation of locomotor rhythm;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005737|cytoplasm;GO:0016604|nuclear body;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0008270|zinc ion binding;GO:0019899|enzyme binding;","K09378","ZFHX3, ATBF1; zinc finger homeobox protein 3"]
["ENSRNOG00000049873",109,9.049905997,62,3.988487167,2.269007174,1.182061171,{"v":1.33233e-07,"d":"1.33E-07"},{"v":2.23305E-7,"d":"2.23E-07"},"up","yes","Ap1s3","protein_coding","chr9:80950715-81009798:-","gi|288541351|ref|NP_001165621.1|",807,{"v":2E-99,"d":"2.00E-99"},"AP-1 complex subunit sigma-3 [Rattus norvegicus]","gi|672065767|ref|XM_008767284.1|",2415,0,"PREDICTED: Rattus norvegicus adaptor-related protein complex 1, sigma 3 subunit (Ap1s3), transcript variant X2, mRNA","Q7TN05",314,{"v":2E-100,"d":"2.00E-100"},"AP-1 complex subunit sigma-3","SPAP27G11.06c",171,{"v":2e-48,"d":"2.00E-48"},"COG5030","pfam01217","Clat_adaptor_s","Clathrin adaptor complex small chain.","GO:0006605|protein targeting;GO:0016192|vesicle-mediated transport;","GO:0030121|AP-1 adaptor complex;GO:0043231|intracellular membrane-bounded organelle;","GO:0035615|clathrin adaptor activity;","K12395","AP1S3; AP-1 complex subunit sigma-3"]
["ENSRNOG00000038328",71,5.894892897,31,1.994243584,2.9559543,1.563623965,{"v":1.35974E-7,"d":"1.36E-07"},{"v":2.27481E-7,"d":"2.27E-07"},"up","yes","Gjc2","protein_coding","chr10:43962642-43970467:-","gi|564372327|ref|XP_006246574.1|",1267,{"v":3e-164,"d":"3.00E-164"},"PREDICTED: gap junction gamma-2 protein isoform X3 [Rattus norvegicus]","gi|294832036|ref|NM_001100784.1|",2081,0,"Rattus norvegicus gap junction protein, gamma 2 (Gjc2), mRNA","Q80XF7",478,{"v":6e-161,"d":"6.00E-161"},"Gap junction gamma-2 protein",".",".",".",".","pfam00029","Connexin","Connexin.","GO:0001932|regulation of protein phosphorylation;GO:0007267|cell-cell signaling;GO:0007420|brain development;GO:0009636|response to toxic substance;GO:0010628|positive regulation of gene expression;GO:0010644|cell communication by electrical coupling;GO:0055085|transmembrane transport;GO:0070447|positive regulation of oligodendrocyte progenitor proliferation;GO:1904427|positive regulation of calcium ion transmembrane transport;GO:2000134|negative regulation of G1/S transition of mitotic cell cycle;","GO:0005921|gap junction;GO:0005922|connexin complex;GO:0016021|integral component of membrane;GO:0033270|paranode region of axon;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0043209|myelin sheath;GO:1990769|proximal neuron projection;","GO:0003674|molecular_function;GO:0005243|gap junction channel activity;GO:1903763|gap junction channel activity involved in cell communication by electrical coupling;","K07619","GJC2, GJA12, CX47; gap junction gamma-2 protein"]
["ENSRNOG00000026039",91,7.555426108,47,3.023530595,2.498875361,1.321278945,{"v":1.45322e-07,"d":"1.45E-07"},{"v":2.42485e-07,"d":"2.42E-07"},"up","yes","Tspan32","protein_coding","chr1:198190164-198204445:+","gi|564298647|ref|XP_002725803.3|",1183,{"v":6E-158,"d":"6.00E-158"},"PREDICTED: tetraspanin-32 isoform X1 [Rattus norvegicus]","gi|672039545|ref|XM_002728846.4|",1514,0,"PREDICTED: Rattus norvegicus pan hematopoietic expression (Phemx), transcript variant X1, mRNA","Q9JHH2",421,{"v":6e-144,"d":"6.00E-144"},"Tetraspanin-32",".",".",".",".","pfam00335","Tetraspannin","Tetraspanin family.","GO:0007010|cytoskeleton organization;GO:0007229|integrin-mediated signaling pathway;GO:0007596|blood coagulation;GO:0007599|hemostasis;GO:0008285|negative regulation of cell proliferation;GO:0030886|negative regulation of myeloid dendritic cell activation;GO:0042832|defense response to protozoan;GO:0050688|regulation of defense response to virus;GO:0051604|protein maturation;GO:0070527|platelet aggregation;GO:0072659|protein localization to plasma membrane;","GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0070442|integrin alphaIIb-beta3 complex;",".","K17359","TSPAN32; tetraspanin-32"]
["ENSRNOG00000022994",97,8.053586071,52,3.345182786,2.407517492,1.26754628,{"v":1.4649e-07,"d":"1.46E-07"},{"v":2.44242e-07,"d":"2.44E-07"},"up","yes","Nlrp5","protein_coding","chr1:67777948-68023736:-","gi|37595473|gb|AAQ94610.1|",4286,0,"MATER protein isoform-E [Mus musculus]","gi|672035009|ref|XM_008758920.1|",2088,0,"PREDICTED: Rattus norvegicus NLR family, pyrin domain containing 5 (Nlrp5), transcript variant X1, mRNA","Q9R1M5",1648,0,"NACHT, LRR and PYD domains-containing protein 5",".",".",".",".","pfam05729","NACHT","NACHT domain. This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.","GO:0001701|in utero embryonic development;GO:0006887|exocytosis;GO:0007015|actin filament organization;GO:0007566|embryo implantation;GO:0009566|fertilization;GO:0009887|animal organ morphogenesis;GO:0031647|regulation of protein stability;GO:0032879|regulation of localization;GO:0034613|cellular protein localization;GO:0034622|cellular protein-containing complex assembly;GO:0040019|positive regulation of embryonic development;GO:0043487|regulation of RNA stability;GO:0051293|establishment of spindle localization;GO:0051302|regulation of cell division;GO:0051656|establishment of organelle localization;GO:0060471|cortical granule exocytosis;","GO:0005634|nucleus;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005938|cell cortex;GO:0032991|protein-containing complex;GO:0045179|apical cortex;GO:0060473|cortical granule;","GO:0015631|tubulin binding;","K22626","NLRP5; NACHT, LRR and PYD domains-containing protein 5"]
["ENSRNOG00000003208",87,7.223319466,44,2.83053928,2.551923415,1.351585033,{"v":1.67772E-7,"d":"1.68E-07"},{"v":2.78637e-07,"d":"2.79E-07"},"up","yes","Ercc6l","protein_coding","chrX:67245414-67280756:-","gi|148886758|ref|NP_001092144.1|",6152,0,"DNA excision repair protein ERCC-6-like [Rattus norvegicus]","gi|148886757|ref|NM_001098674.1|",4000,0,"Rattus norvegicus excision repair cross-complementation group 6-like (Ercc6l), mRNA","Q8BHK9",2021,0,"DNA excision repair protein ERCC-6-like","ECU09g0410",297,{"v":2E-85,"d":"2.00E-85"},"COG0553","pfam00176","SNF2_N","SNF2 family N-terminal domain. This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1).",".",".","GO:0005524|ATP binding;GO:0015616|DNA translocase activity;","K20093","ERCC6L, PICH; DNA excision repair protein ERCC-6-like [EC:5.6.2.-]"]
["ENSRNOG00000017689",22,1.826586532,0,0.032165219,56.78762909,5.827504775,{"v":1.76238e-07,"d":"1.76E-07"},{"v":2.92242e-07,"d":"2.92E-07"},"up","yes","Itih3","protein_coding","chr16:6101930-6116924:-","gi|672079321|ref|XP_008769224.1|",4719,0,"PREDICTED: inter-alpha-trypsin inhibitor heavy chain H3 isoform X2 [Rattus norvegicus]","gi|672079320|ref|XM_008771002.1|",2806,0,"PREDICTED: Rattus norvegicus inter-alpha trypsin inhibitor, heavy chain 3 (Itih3), transcript variant X2, mRNA","Q63416",1756,0,"Inter-alpha-trypsin inhibitor heavy chain H3","alr4412",86.7,{"v":2E-16,"d":"2.00E-16"},"COG2304","pfam06668","ITI_HC_C","Inter-alpha-trypsin inhibitor heavy chain C-terminus. This family represents the C-terminal region of inter-alpha-trypsin inhibitor heavy chains. Inter-alpha-trypsin inhibitors are glycoproteins with a high inhibitory activity against trypsin, built up from different combinations of four polypeptides: bikunin and the three heavy chains that belong to this family (HC1, HC2, HC3). The heavy chains do not have any protease inhibitory properties but have the capacity to interact in vitro and in vivo with hyaluronic acid, which promotes the stability of the extra-cellular matrix. All family members contain the pfam00092 domain.","GO:0010951|negative regulation of endopeptidase activity;GO:0030212|hyaluronan metabolic process;","GO:0005576|extracellular region;","GO:0004867|serine-type endopeptidase inhibitor activity;","K24513","ITIH3, SHAP; inter-alpha-trypsin inhibitor heavy chain H3"]
["ENSRNOG00000020337",22,1.826586532,0,0.032165219,56.78762909,5.827504775,{"v":1.76238e-07,"d":"1.76E-07"},{"v":2.92242e-07,"d":"2.92E-07"},"up","yes","Sla2","protein_coding","chr3:145368598-145382480:-","gi|287323377|ref|NP_001165589.1|",1110,{"v":2e-146,"d":"2.00E-146"},"src-like-adapter 2 [Rattus norvegicus]","gi|672047615|ref|XM_008762374.1|",1107,0,"PREDICTED: Rattus norvegicus Src-like-adaptor 2 (Sla2), transcript variant X1, mRNA","Q8R4L0",398,{"v":6e-135,"d":"6.00E-135"},"Src-like-adapter 2",".",".",".",".","pfam00017","SH2","SH2 domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0042110|T cell activation;GO:0043551|regulation of phosphatidylinositol 3-kinase activity;GO:0046854|phosphatidylinositol phosphorylation;GO:0050849|negative regulation of calcium-mediated signaling;GO:0050860|negative regulation of T cell receptor signaling pathway;","GO:0005654|nucleoplasm;GO:0005770|late endosome;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005942|phosphatidylinositol 3-kinase complex;GO:0031410|cytoplasmic vesicle;GO:0043231|intracellular membrane-bounded organelle;","GO:0035591|signaling adaptor activity;GO:0046935|1-phosphatidylinositol-3-kinase regulator activity;GO:0047485|protein N-terminus binding;","K23698","SLA; src-like-adapter"]
["ENSRNOG00000014918",40,3.321066421,10,0.643304382,5.162511736,2.368073156,{"v":1.87076E-7,"d":"1.87E-07"},{"v":3.0941e-07,"d":"3.09E-07"},"up","yes","Klrg1","protein_coding","chr4:155455495-155467424:-","gi|13928898|ref|NP_113837.1|",1003,{"v":1e-131,"d":"1.00E-131"},"killer cell lectin-like receptor subfamily G member 1 [Rattus norvegicus]","gi|1020141|emb|X79812.1|",1388,0,"R.norvegicus mafa mRNA for mast cell function associated antigen","Q64335",390,{"v":4e-133,"d":"4.00E-133"},"Killer cell lectin-like receptor subfamily G member 1",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0045087|innate immune response;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0030246|carbohydrate binding;","K10076","KLRG1; killer cell lectin-like receptor subfamily G member 1"]
["ENSRNOG00000018570",31,2.573826476,5,0.321652191,8.001893191,3.000341372,{"v":1.88981e-07,"d":"1.89E-07"},{"v":3.1248E-7,"d":"3.12E-07"},"up","yes","C1qtnf3","protein_coding","chr2:59917188-59939433:+","gi|197313725|ref|NP_001127908.1|",1407,0,"complement C1q tumor necrosis factor-related protein 3 precursor [Rattus norvegicus]","gi|197313724|ref|NM_001134436.1|",1920,0,"Rattus norvegicus C1q and tumor necrosis factor related protein 3 (C1qtnf3), mRNA","Q9ES30",365,{"v":1e-120,"d":"1.00E-120"},"Complement C1q tumor necrosis factor-related protein 3",".",".",".",".","pfam00386","C1q","C1q domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.","GO:0001819|positive regulation of cytokine production;GO:0010629|negative regulation of gene expression;GO:0032715|negative regulation of interleukin-6 production;GO:0035356|cellular triglyceride homeostasis;GO:0042593|glucose homeostasis;GO:0045444|fat cell differentiation;GO:0045721|negative regulation of gluconeogenesis;GO:0050728|negative regulation of inflammatory response;GO:0051897|positive regulation of protein kinase B signaling;GO:0070165|positive regulation of adiponectin secretion;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071638|negative regulation of monocyte chemotactic protein-1 production;GO:1901223|negative regulation of NIK/NF-kappaB signaling;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0032991|protein-containing complex;","GO:0042802|identical protein binding;","K24236","C1QTNF3; complement C1q and tumor necrosis factor-related protein 3"]
["ENSRNOG00000015794",116,9.631092621,69,4.438800235,2.169751309,1.117529695,{"v":1.9729e-07,"d":"1.97E-07"},{"v":3.25043e-07,"d":"3.25E-07"},"up","yes","Fam83d","protein_coding","chr3:147421908-147441192:+","gi|157821539|ref|NP_001101266.1|",2825,0,"protein FAM83D [Rattus norvegicus]","gi|157821538|ref|NM_001107796.1|",2236,0,"Rattus norvegicus family with sequence similarity 83, member D (Fam83d), mRNA","Q9D7I8",1020,0,"Protein FAM83D",".",".",".",".","pfam07894","DUF1669","Protein of unknown function (DUF1669). This family is composed of sequences derived from hypothetical eukaryotic proteins of unknown function. Some members of this family are annotated as being potential phospholipases but no literature was found to support this.","GO:0001837|epithelial to mesenchymal transition;GO:0007165|signal transduction;GO:0008283|cell proliferation;GO:0016477|cell migration;GO:0032006|regulation of TOR signaling;GO:0042176|regulation of protein catabolic process;GO:0051310|metaphase plate congression;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:1902480|protein localization to mitotic spindle;GO:1902808|positive regulation of cell cycle G1/S phase transition;","GO:0005737|cytoplasm;GO:0005819|spindle;GO:0005829|cytosol;GO:0015630|microtubule cytoskeleton;GO:0045171|intercellular bridge;GO:0072686|mitotic spindle;GO:0097431|mitotic spindle pole;","GO:0008017|microtubule binding;GO:0019894|kinesin binding;GO:0019901|protein kinase binding;","K16805","FAM83D, CHICA; protein FAM83D"]
["ENSRNOG00000000956",90,7.472399447,47,3.023530595,2.471415193,1.305337401,{"v":2.21155E-7,"d":"2.21E-07"},{"v":3.63052e-07,"d":"3.63E-07"},"up","yes","Rasl11a","protein_coding","chr12:8258159-8262576:-","gi|564378145|ref|XP_006248896.1|",1387,0,"PREDICTED: ras-like protein family member 11A isoform X1 [Rattus norvegicus]","gi|672071969|ref|XM_006248834.2|",1056,0,"PREDICTED: Rattus norvegicus RAS-like family 11 member A (Rasl11a), transcript variant X1, mRNA","Q6IMA3",441,{"v":1E-153,"d":"1.00E-153"},"Ras-like protein family member 11A",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0045943|positive regulation of transcription by RNA polymerase I;","GO:0005730|nucleolus;","GO:0003924|GTPase activity;GO:0005525|GTP binding;","K07852","RASL11A; Ras-like protein family member 11A"]
["ENSRNOG00000026762",66,5.479759595,28,1.801252269,3.042194416,1.605112353,{"v":2.22962e-07,"d":"2.23E-07"},{"v":3.65831e-07,"d":"3.66E-07"},"up","yes","RT1-DOa","protein_coding","chr20:4753598-4756577:-","gi|258613960|ref|NP_898874.2|",1194,{"v":2e-161,"d":"2.00E-161"},"RT1 class II, locus DOa precursor [Rattus norvegicus]","gi|672085583|ref|XM_006255914.2|",1169,0,"PREDICTED: Rattus norvegicus RT1 class II, locus DOa (RT1-DOa), transcript variant X1, mRNA","P06340",344,{"v":8E-116,"d":"8.00E-116"},"HLA class II histocompatibility antigen, DO alpha chain",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.","GO:0002250|adaptive immune response;GO:0002381|immunoglobulin production involved in immunoglobulin mediated immune response;GO:0002503|peptide antigen assembly with MHC class II protein complex;GO:0002587|negative regulation of antigen processing and presentation of peptide antigen via MHC class II;GO:0019882|antigen processing and presentation;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0045580|regulation of T cell differentiation;GO:0050870|positive regulation of T cell activation;","GO:0016021|integral component of membrane;GO:0042613|MHC class II protein complex;","GO:0023026|MHC class II protein complex binding;","K06752","MHC2; MHC class II antigen"]
["ENSRNOG00000065465",38,3.1550131,9,0.578973944,5.449317943,2.446075668,{"v":2.259E-7,"d":"2.26E-07"},{"v":3.70366E-7,"d":"3.70E-07"},"up","yes","ENSRNOG00000065465","lncRNA","chr8:73863112-73865235:+",".",".",".",".","gi|260441712|gb|AC128582.3|",966,0,"Rattus norvegicus BAC CH230-349P12 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam12533","Neuro_bHLH","Neuronal helix-loop-helix transcription factor. This domain family is found in eukaryotes, and is approximately 80 amino acids in length. The family is found C-terminal to pfam00010. There is a single completely conserved residue W that may be functionally important. Neuronal basic helix-loop-helix (bHLH) transcription factors such as neuroD and neurogenin have been shown to play important roles in neuronal development.",".",".",".",".","."]
["ENSRNOG00000010832",111,9.215959318,65,4.181478482,2.203995395,1.14012121,{"v":2.32705e-07,"d":"2.33E-07"},{"v":3.81132e-07,"d":"3.81E-07"},"up","yes","Pdgfrl","protein_coding","chr16:51347948-51407850:-","gi|58865412|ref|NP_001011921.1|",1876,0,"platelet-derived growth factor receptor-like protein precursor [Rattus norvegicus]","gi|58865411|ref|NM_001011921.1|",1467,0,"Rattus norvegicus platelet-derived growth factor receptor-like (Pdgfrl), mRNA","Q5RJP7",727,0,"Platelet-derived growth factor receptor-like protein",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005576|extracellular region;","GO:0003674|molecular_function;","K25716","PDGFRL; platelet-derived growth factor receptor-like protein"]
["ENSRNOG00000068391",75,6.226999539,35,2.251565336,2.765631287,1.46760883,{"v":2.34461E-7,"d":"2.34E-07"},{"v":3.83809e-07,"d":"3.84E-07"},"up","yes","ENSRNOG00000068391","lncRNA","chr5:138131975-138133310:+","gi|51457|emb|CAA34748.1|",1241,{"v":3e-167,"d":"3.00E-167"},"heat shock-like protein [Mus musculus]","gi|48734826|gb|BC072489.1|",1333,0,"Rattus norvegicus heat shock protein 90, alpha (cytosolic), class A member 1, mRNA (cDNA clone MGC:91423 IMAGE:7105514), complete cds","P82995",484,{"v":1e-162,"d":"1.00E-162"},"Heat shock protein HSP 90-alpha","SPAC926.04c",241,{"v":7e-71,"d":"7.00E-71"},"COG0326","pfam00183","HSP90","Hsp90 protein.",".",".",".",".","."]
["ENSRNOG00000003310",133,11.04254585,85,5.468087246,2.01945312,1.013964656,{"v":2.67028e-07,"d":"2.67E-07"},{"v":4.34012e-07,"d":"4.34E-07"},"up","yes","Tmem63a","protein_coding","chr13:92663968-92696183:+","gi|564382020|ref|XP_006250426.1|",3940,0,"PREDICTED: CSC1-like protein 1 isoform X2 [Rattus norvegicus]","gi|672075044|ref|XM_006250364.2|",3431,0,"PREDICTED: Rattus norvegicus transmembrane protein 63a (Tmem63a), transcript variant X1, mRNA","Q91YT8",1446,0,"CSC1-like protein 1",".",".",".",".","pfam02714","DUF221","Domain of unknown function DUF221. This family consists of hypothetical transmembrane proteins none of which have any function, the aligned region is at 538 residues at maximum length.","GO:0098655|cation transmembrane transport;","GO:0005765|lysosomal membrane;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0034451|centriolar satellite;GO:0043231|intracellular membrane-bounded organelle;","GO:0003676|nucleic acid binding;GO:0005227|calcium activated cation channel activity;GO:0008381|mechanosensitive ion channel activity;GO:1990760|osmolarity-sensing cation channel activity;","K21989","TMEM63, CSC1; calcium permeable stress-gated cation channel"]
["ENSRNOG00000066159",68,5.645812916,30,1.929913146,2.925423317,1.548645402,{"v":3.02442E-7,"d":"3.02E-07"},{"v":4.89209e-07,"d":"4.89E-07"},"up","yes","Cpm","protein_coding","chr7:53225696-53286220:+","gi|157821719|ref|NP_001101568.1|",2395,0,"carboxypeptidase M precursor [Rattus norvegicus]","gi|157821718|ref|NM_001108098.1|",5442,0,"Rattus norvegicus carboxypeptidase M (Cpm), mRNA","Q80V42",881,0,"Carboxypeptidase M","sll0236",70.5,{"v":3E-11,"d":"3.00E-11"},"COG2866","pfam00246","Peptidase_M14","Zinc carboxypeptidase.",".",".",".",".","."]
["ENSRNOG00000057643",24,1.992639853,2,0.128660876,15.48753521,3.953035657,{"v":3.04703E-7,"d":"3.05E-07"},{"v":4.92742e-07,"d":"4.93E-07"},"up","yes","Klri2","protein_coding","chr4:163252844-163261484:-","gi|60593067|ref|NP_001012666.1|",1314,0,"killer cell lectin-like receptor family I member 2 [Rattus norvegicus]","gi|60593066|ref|NM_001012648.1|",837,0,"Rattus norvegicus killer cell lectin-like receptor family I member 2 (Klri2), mRNA","Q5DT37",510,0,"Killer cell lectin-like receptor subfamily I member 2",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type",".","GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;","GO:0030246|carbohydrate binding;",".","."]
["ENSRNOG00000003233",44,3.653173063,13,0.836295696,4.368279161,2.127065057,{"v":3.06824E-7,"d":"3.07E-07"},{"v":4.96047e-07,"d":"4.96E-07"},"up","yes","Serpinf2","protein_coding","chr10:60272400-60281243:-","gi|564372692|ref|XP_006246737.1|",2236,0,"PREDICTED: alpha-2-antiplasmin isoform X1 [Rattus norvegicus]","gi|564372691|ref|XM_006246675.1|",2223,0,"PREDICTED: Rattus norvegicus serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 (Serpinf2), transcript variant X1, mRNA","Q61247",632,0,"Alpha-2-antiplasmin","all0778",85.9,{"v":7e-17,"d":"7.00E-17"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0002034|regulation of blood vessel diameter by renin-angiotensin;GO:0010033|response to organic substance;GO:0010757|negative regulation of plasminogen activation;GO:0010951|negative regulation of endopeptidase activity;GO:0030199|collagen fibril organization;GO:0032967|positive regulation of collagen biosynthetic process;GO:0045597|positive regulation of cell differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046330|positive regulation of JNK cascade;GO:0048514|blood vessel morphogenesis;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0051496|positive regulation of stress fiber assembly;GO:0051918|negative regulation of fibrinolysis;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071636|positive regulation of transforming growth factor beta production;","GO:0005577|fibrinogen complex;GO:0005615|extracellular space;GO:0009986|cell surface;","GO:0002020|protease binding;GO:0004867|serine-type endopeptidase inhibitor activity;GO:0042803|protein homodimerization activity;","K03983","SERPINF2, AAP; alpha-2-antiplasmin"]
["ENSRNOG00000053772",21,1.743559871,0,0.032165219,54.20637323,5.760390579,{"v":3.3439e-07,"d":"3.34E-07"},{"v":5.3857e-07,"d":"5.39E-07"},"up","yes","Klra22","protein_coding","chr4:164036383-164057805:-","gi|56123191|gb|AAV74512.1|",1395,0,"Ly49 stimulatory receptor 2 [Rattus norvegicus]","gi|56123190|gb|AY649838.1|",811,0,"Rattus norvegicus Ly49 stimulatory receptor 2 (Ly49s2) mRNA, complete cds","P20937",337,{"v":3e-112,"d":"3.00E-112"},"T-cell surface glycoprotein YE1/48",".",".",".",".","pfam08391","Ly49","Ly49-like protein, N-terminal region. The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000069549",26,2.158693174,3,0.192991315,11.18544209,3.483550374,{"v":3.49299e-07,"d":"3.49E-07"},{"v":5.61593e-07,"d":"5.62E-07"},"up","yes","ENSRNOG00000069549","protein_coding","chr5:23768429-23768806:+","gi|678336953|emb|CDW75723.1|",372,{"v":2e-38,"d":"2.00E-38"},"UNKNOWN [Stylonychia lemnae]","gi|374429576|ref|NR_046246.1|",353,0,"Rattus norvegicus 28S ribosomal RNA (Rn28s), ribosomal RNA",".",".",".",".",".",".",".",".","pfam12979","DUF3863","Domain of Unknown Function with PDB structure (DUF3863). Domain based on 1-364 domain of PDB:3LM3 which is encoded by the BDI_3119 gene from Parabacteroides distasonis atcc 8503.",".",".",".",".","."]
["ENSRNOG00000025638",131,10.87649253,84,5.403756808,2.012764992,1.009178735,{"v":3.64488E-7,"d":"3.64E-07"},{"v":5.84397e-07,"d":"5.84E-07"},"up","yes","Npm2","protein_coding","chr15:45722400-45729726:-","gi|42714644|ref|NP_976085.1|",775,{"v":2E-100,"d":"2.00E-100"},"nucleoplasmin-2 [Rattus norvegicus]","gi|672078571|ref|XM_006252261.2|",673,0,"PREDICTED: Rattus norvegicus nucleophosmin/nucleoplasmin 2 (Npm2), transcript variant X1, mRNA","Q80W85",262,{"v":3e-86,"d":"3.00E-86"},"Nucleoplasmin-2",".",".",".",".","pfam03066","Nucleoplasmin","Nucleoplasmin. Nucleoplasmins are also known as chromatin decondensation proteins. They bind to core histones and transfer DNA to them in a reaction that requires ATP. This is thought to play a role in the assembly of regular nucleosomal arrays.","GO:0001824|blastocyst development;GO:0006338|chromatin remodeling;GO:0007096|regulation of exit from mitosis;GO:0007338|single fertilization;GO:0009994|oocyte differentiation;GO:0043085|positive regulation of catalytic activity;GO:0045740|positive regulation of DNA replication;GO:0045836|positive regulation of meiotic nuclear division;GO:0051054|positive regulation of DNA metabolic process;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;","GO:0003682|chromatin binding;GO:0003723|RNA binding;GO:0019899|enzyme binding;GO:0042393|histone binding;GO:0042802|identical protein binding;","K11277","NPM2; nucleophosmin 2"]
["ENSRNOG00000036641",28,2.324746495,4,0.257321753,9.034395538,3.175428078,{"v":3.70163E-7,"d":"3.70E-07"},{"v":5.9305e-07,"d":"5.93E-07"},"up","yes","ENSRNOG00000036641","protein_coding","chr1:201784009-201785916:-","gi|157817095|ref|NP_001102991.1|",621,{"v":1e-76,"d":"1.00E-76"},"uncharacterized protein C11orf86 homolog [Rattus norvegicus]","gi|672039511|ref|XM_006230905.2|",1212,0,"PREDICTED: Rattus norvegicus hypothetical protein LOC689065 (LOC689065), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam15464","DUF4633","Domain of unknown function (DUF4633). This family of proteins is found in eukaryotes. Proteins in this family are typically between 94 and 123 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000053309",107,8.883852676,63,4.052817606,2.192018872,1.132260219,{"v":4.44244e-07,"d":"4.44E-07"},{"v":7.06778e-07,"d":"7.07E-07"},"up","yes","Tubd1","protein_coding","chr10:71368133-71391266:+","gi|149053750|gb|EDM05567.1|",2445,0,"tubulin, delta 1 (predicted), isoform CRA_b [Rattus norvegicus]","gi|312261241|ref|NM_001199047.1|",1142,0,"Mus musculus tubulin, delta 1 (Tubd1), transcript variant 4, mRNA","Q9R1K7",896,0,"Tubulin delta chain","SPBC32F12.04",152,{"v":5e-39,"d":"5.00E-39"},"COG5023","pfam00091","Tubulin","Tubulin/FtsZ family, GTPase domain. This family includes the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division. It is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules.","GO:0030030|cell projection organization;GO:0045880|positive regulation of smoothened signaling pathway;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005814|centriole;GO:0005829|cytosol;GO:0005929|cilium;","GO:0003924|GTPase activity;","K10390","TUBD; tubulin delta"]
["ENSRNOG00000021285",87,7.223319466,46,2.959200157,2.440970223,1.287454696,{"v":4.6711e-07,"d":"4.67E-07"},{"v":7.40578e-07,"d":"7.41E-07"},"up","yes","Celsr1","protein_coding","chr7:116987605-117125164:-","gi|564309130|ref|XP_006226250.1|",14958,0,"PREDICTED: cadherin EGF LAG seven-pass G-type receptor 1 isoform X1 [Rattus norvegicus]","gi|672060456|ref|XM_008765821.1|",9561,0,"PREDICTED: Rattus norvegicus cadherin, EGF LAG seven-pass G-type receptor 1 (Celsr1), transcript variant X3, mRNA","O35161",5545,0,"Cadherin EGF LAG seven-pass G-type receptor 1",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0001736|establishment of planar polarity;GO:0001764|neuron migration;GO:0001843|neural tube closure;GO:0001942|hair follicle development;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007266|Rho protein signal transduction;GO:0007626|locomotory behavior;GO:0008150|biological_process;GO:0009952|anterior/posterior pattern specification;GO:0032956|regulation of actin cytoskeleton organization;GO:0042060|wound healing;GO:0042249|establishment of planar polarity of embryonic epithelium;GO:0042472|inner ear morphogenesis;GO:0045176|apical protein localization;GO:0048105|establishment of body hair planar orientation;GO:0060488|orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis;GO:0060489|planar dichotomous subdivision of terminal units involved in lung branching morphogenesis;GO:0060490|lateral sprouting involved in lung morphogenesis;GO:0090179|planar cell polarity pathway involved in neural tube closure;GO:0090251|protein localization involved in establishment of planar polarity;GO:0098609|cell-cell adhesion;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0004930|G protein-coupled receptor activity;GO:0005509|calcium ion binding;","K04600","CELSR1; cadherin EGF LAG seven-pass G-type receptor 1"]
["ENSRNOG00000021217",59,4.898572971,24,1.543930516,3.172793671,1.665753705,{"v":4.93997e-07,"d":"4.94E-07"},{"v":7.81268E-7,"d":"7.81E-07"},"up","yes","Itga10","protein_coding","chr2:184182869-184202172:+","gi|164565428|ref|NP_001101169.2|",5856,0,"integrin alpha-10 precursor [Rattus norvegicus]","gi|164565427|ref|NM_001107699.2|",3843,0,"Rattus norvegicus integrin subunit alpha 10 (Itga10), mRNA","O75578",1975,0,"Integrin alpha-10",".",".",".",".","pfam08441","Integrin_alpha2","Integrin alpha. This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.","GO:0007160|cell-matrix adhesion;GO:0007229|integrin-mediated signaling pathway;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0034680|integrin alpha10-beta1 complex;","GO:0003674|molecular_function;GO:0046872|metal ion binding;GO:0098639|collagen binding involved in cell-matrix adhesion;","K06586","ITGA10; integrin alpha 10"]
["ENSRNOG00000020563",21,1.743559871,1,0.064330438,27.10318661,4.760390579,{"v":5.30366e-07,"d":"5.30E-07"},{"v":8.3713e-07,"d":"8.37E-07"},"up","yes","Cma1","protein_coding","chr15:29417451-29420233:-","gi|6978667|ref|NP_037224.1|",1197,{"v":7e-163,"d":"7.00E-163"},"chymase precursor [Rattus norvegicus]","gi|6978666|ref|NM_013092.1|",974,0,"Rattus norvegicus chymase 1 (Cma1), mRNA","P50339",465,{"v":2e-164,"d":"2.00E-164"},"Chymase","VC1200",58.2,1E-8,"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;GO:0006518|peptide metabolic process;GO:0022617|extracellular matrix disassembly;GO:0030901|midbrain development;GO:0034769|basement membrane disassembly;GO:0045766|positive regulation of angiogenesis;GO:0050727|regulation of inflammatory response;GO:0071333|cellular response to glucose stimulus;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005829|cytosol;GO:0030141|secretory granule;GO:0036464|cytoplasmic ribonucleoprotein granule;","GO:0004175|endopeptidase activity;GO:0004252|serine-type endopeptidase activity;GO:0008233|peptidase activity;GO:0008236|serine-type peptidase activity;GO:0042277|peptide binding;","K01329","CMA1; chymase [EC:3.4.21.39]"]
["ENSRNOG00000019112",84,6.974239484,44,2.83053928,2.463926056,1.30095896,{"v":5.97734E-7,"d":"5.98E-07"},{"v":9.36759E-7,"d":"9.37E-07"},"up","yes","Chp2","protein_coding","chr1:176757876-176772139:+","gi|672037923|ref|XP_008757967.1|",1320,{"v":1e-178,"d":"1.00E-178"},"PREDICTED: calcineurin B homologous protein 2 isoform X2 [Rattus norvegicus]","gi|672037922|ref|XM_008759745.1|",1354,0,"PREDICTED: Rattus norvegicus calcineurin-like EF hand protein 2 (Chp2), transcript variant X1, mRNA","Q810D1",395,{"v":1E-134,"d":"1.00E-134"},"Calcineurin B homologous protein 2","YKL190w",113,{"v":3E-28,"d":"3.00E-28"},"COG5126","pfam13499","EF-hand_7","EF-hand domain pair.","GO:0006883|cellular sodium ion homeostasis;GO:0008284|positive regulation of cell proliferation;GO:0010922|positive regulation of phosphatase activity;GO:0015031|protein transport;GO:0030641|regulation of cellular pH;GO:0042307|positive regulation of protein import into nucleus;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0070886|positive regulation of calcineurin-NFAT signaling cascade;GO:0071277|cellular response to calcium ion;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0009898|cytoplasmic side of plasma membrane;","GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0019904|protein domain specific binding;","K17611","CHP2; calcineurin B homologous protein 2"]
["ENSRNOG00000057729",97,8.053586071,55,3.5381741,2.276198356,1.186626285,{"v":6.0126e-07,"d":"6.01E-07"},{"v":9.41361e-07,"d":"9.41E-07"},"up","yes","Strip2","protein_coding","chr4:58536055-58578291:+","gi|589933354|ref|XP_006979464.1|",3824,0,"PREDICTED: striatin-interacting proteins 2-like isoform X1 [Peromyscus maniculatus bairdii]","gi|672049446|ref|XM_008762856.1|",4674,0,"PREDICTED: Rattus norvegicus similar to Protein FAM40B (LOC500066), transcript variant X2, mRNA","Q8C9H6",1470,0,"Striatin-interacting proteins 2",".",".",".",".","pfam11882","DUF3402","Domain of unknown function (DUF3402). This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is typically between 350 to 473 amino acids in length. This domain is found associated with pfam07923.","GO:0007010|cytoskeleton organization;GO:0008360|regulation of cell shape;GO:0016477|cell migration;","GO:0005737|cytoplasm;GO:0005829|cytosol;",".",".","."]
["ENSRNOG00000025645",23,1.909613192,2,0.128660876,14.84222124,3.891635112,{"v":6.11248e-07,"d":"6.11E-07"},{"v":9.56062e-07,"d":"9.56E-07"},"up","yes","Abca13","protein_coding","chr14:83873940-84375075:+","gi|158187533|ref|NP_001099490.2|",25879,0,"ATP-binding cassette, sub-family A (ABC1), member 13 [Rattus norvegicus]","gi|158187532|ref|NM_001106020.2|",14919,0,"Rattus norvegicus ATP-binding cassette, subfamily A (ABC1), member 13 (Abca13), mRNA","Q5SSE9",8673,0,"ATP-binding cassette sub-family A member 13","PAE0269",173,{"v":4e-45,"d":"4.00E-45"},"COG1131","pfam00005","ABC_tran","ABC transporter. ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide or belong in different polypeptide chains.","GO:0006869|lipid transport;GO:0008150|biological_process;GO:0032376|positive regulation of cholesterol transport;GO:0035627|ceramide transport;GO:0055085|transmembrane transport;GO:1900244|positive regulation of synaptic vesicle endocytosis;","GO:0005575|cellular_component;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0097708|intracellular vesicle;","GO:0003674|molecular_function;GO:0005319|lipid transporter activity;GO:0005524|ATP binding;GO:0042626|ATPase activity, coupled to transmembrane movement of substances;","K05647","ABCA13; ATP binding cassette, subfamily A (ABC1), member 13"]
["ENSRNOG00000042524",23,1.909613192,2,0.128660876,14.84222124,3.891635112,{"v":6.11248e-07,"d":"6.11E-07"},{"v":9.56062e-07,"d":"9.56E-07"},"up","yes","Milr1","protein_coding","chr10:91687831-91705282:+","gi|149054592|gb|EDM06409.1|",1197,{"v":5e-159,"d":"5.00E-159"},"mast cell antigen 32, isoform CRA_a [Rattus norvegicus]","gi|11024661|ref|NM_021585.1|",1650,0,"Rattus norvegicus mast cell immunoglobulin-like receptor 1 (Milr1), mRNA","Q62875",418,{"v":2e-142,"d":"2.00E-142"},"Allergin-1",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0007166|cell surface receptor signaling pathway;GO:0033004|negative regulation of mast cell activation;GO:0043303|mast cell degranulation;GO:0098742|cell-cell adhesion via plasma-membrane adhesion molecules;","GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;","GO:0004888|transmembrane signaling receptor activity;",".","."]
["ENSRNOG00000021345",20,1.66053321,0,0.032165219,51.62511736,5.690001251,{"v":6.3752e-07,"d":"6.38E-07"},{"v":9.95207E-7,"d":"9.95E-07"},"up","yes","Timd2","protein_coding","chr10:31060326-31094623:-","gi|672067246|ref|XP_008765889.1|",721,{"v":2E-87,"d":"2.00E-87"},"PREDICTED: T-cell immunoglobulin and mucin domain-containing protein 2 isoform X2 [Rattus norvegicus]","gi|62079096|ref|NM_001013855.1|",1334,0,"Rattus norvegicus T-cell immunoglobulin and mucin domain containing 2 (Timd2), mRNA","Q5FVR0",273,{"v":5e-86,"d":"5.00E-86"},"T-cell immunoglobulin and mucin domain-containing protein 2",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0006826|iron ion transport;GO:0006911|phagocytosis, engulfment;GO:0033005|positive regulation of mast cell activation;GO:0046718|viral entry into host cell;","GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0001618|virus receptor activity;GO:0001786|phosphatidylserine binding;GO:0070287|ferritin receptor activity;","K20413","HAVCR1, CD365; hepatitis A virus cellular receptor 1"]
["ENSRNOG00000047367",85,7.057266145,45,2.894869718,2.437852764,1.285610996,{"v":6.50634e-07,"d":"6.51E-07"},{"v":1.01494e-06,"d":"1.01E-06"},"up","yes","Card14","protein_coding","chr10:104566424-104601905:+","gi|564313819|ref|XP_006221025.1|",4658,0,"PREDICTED: caspase recruitment domain-containing protein 14 [Rattus norvegicus]","gi|568971961|ref|XM_006532373.1|",2855,0,"PREDICTED: Mus musculus caspase recruitment domain family, member 14 (Card14), transcript variant X8, mRNA","Q99KF0",1735,0,"Caspase recruitment domain-containing protein 14",".",".",".",".","pfam00619","CARD","Caspase recruitment domain. Motif contained in proteins involved in apoptotic signaling. Predicted to possess a DEATH (pfam00531) domain-like fold.","GO:0001934|positive regulation of protein phosphorylation;GO:0033209|tumor necrosis factor-mediated signaling pathway;GO:0043066|negative regulation of apoptotic process;GO:0051092|positive regulation of NF-kappaB transcription factor activity;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016235|aggresome;","GO:0050700|CARD domain binding;","K20913","CARD14; caspase recruitment domain-containing protein 14"]
["ENSRNOG00000022283",31,2.573826476,6,0.385982629,6.668244325,2.737306966,{"v":6.53197e-07,"d":"6.53E-07"},{"v":1.01868E-6,"d":"1.02E-06"},"up","yes","Lhfpl5","protein_coding","chr20:6632362-6642532:+","gi|62078543|ref|NP_001013928.1|",1160,{"v":8e-156,"d":"8.00E-156"},"tetraspan membrane protein of hair cell stereocilia [Rattus norvegicus]","gi|62078542|ref|NM_001013906.1|",1349,0,"Rattus norvegicus lipoma HMGIC fusion partner-like 5 (Lhfpl5), mRNA","Q5PPI7",451,{"v":3E-157,"d":"3.00E-157"},"LHFPL tetraspan subfamily member 5 protein",".",".",".",".","pfam10242","L_HGMIC_fpl","Lipoma HMGIC fusion partner-like protein. This is a group of proteins expressed from a series of genes referred to as Lipoma HGMIC fusion partner-like. The proteins carry four highly conserved transmembrane domains in this entry. In certain instances, eg in LHFPL5, mutations cause deafness in humans and hypospadias, and LHFPL1 is transcribed in six liver tumor cell lines.","GO:0006811|ion transport;GO:0007605|sensory perception of sound;GO:0050910|detection of mechanical stimulus involved in sensory perception of sound;GO:0050974|detection of mechanical stimulus involved in sensory perception;GO:0060088|auditory receptor cell stereocilium organization;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0032421|stereocilium bundle;GO:0032426|stereocilium tip;",".","K23893","LHFPL; LHFPL tetraspan subfamily member protein"]
["ENSRNOG00000016753",29,2.407773155,5,0.321652191,7.485642017,2.904126056,{"v":7.07071e-07,"d":"7.07E-07"},{"v":1.09762E-6,"d":"1.10E-06"},"up","yes","Slc14a1","protein_coding","chr18:71565454-71595146:-","gi|672083551|ref|XP_008770390.1|",2059,0,"PREDICTED: urea transporter 1 isoform X2 [Rattus norvegicus]","gi|672083550|ref|XM_008772168.1|",3742,0,"PREDICTED: Rattus norvegicus solute carrier family 14 (urea transporter), member 1 (Slc14a1), transcript variant X1, mRNA","P97689",679,0,"Urea transporter 1","SA2081",83.6,{"v":3e-16,"d":"3.00E-16"},"COG4413","pfam03253","UT","Urea transporter. Members of this family transport urea across membranes. The family includes a bacterial homologue, Actinobacillus pleuropneumoniae urea transport protein Utp.","GO:0006833|water transport;GO:0015840|urea transport;GO:0071918|urea transmembrane transport;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016323|basolateral plasma membrane;","GO:0005372|water transmembrane transporter activity;GO:0015204|urea transmembrane transporter activity;GO:0015265|urea channel activity;","K08716","SLC14A; solute carrier family 14 (urea transporter)"]
["ENSRNOG00000029564",29,2.407773155,5,0.321652191,7.485642017,2.904126056,{"v":7.07071e-07,"d":"7.07E-07"},{"v":1.09762E-6,"d":"1.10E-06"},"up","yes","Trat1","protein_coding","chr11:52035750-52077805:+","gi|83816943|ref|NP_001033070.1|",816,{"v":2e-102,"d":"2.00E-102"},"T cell receptor associated transmembrane adaptor 1 [Rattus norvegicus]","gi|83816942|ref|NM_001037981.1|",1820,0,"Rattus norvegicus T cell receptor associated transmembrane adaptor 1 (Trat1), mRNA","Q3UU67",282,{"v":1E-89,"d":"1.00E-89"},"T-cell receptor-associated transmembrane adapter 1",".",".",".",".","pfam15330","SIT","SHP2-interacting transmembrane adaptor protein, SIT. SIT, or SHP2-interacting transmembrane adaptor protein, is a disulfide-linked dimer that regulates human T Cell activation.","GO:0001920|negative regulation of receptor recycling;GO:0050850|positive regulation of calcium-mediated signaling;GO:0050862|positive regulation of T cell receptor signaling pathway;GO:0051051|negative regulation of transport;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0034451|centriolar satellite;GO:0042101|T cell receptor complex;GO:0072686|mitotic spindle;",".",".","."]
["ENSRNOG00000028077",27,2.241719834,4,0.257321753,8.711738554,3.122960658,{"v":7.25367e-07,"d":"7.25E-07"},{"v":1.1252E-6,"d":"1.13E-06"},"up","yes","Cfap44","protein_coding","chr11:56201049-56283986:-","gi|672071361|ref|XP_008767007.1|",8288,0,"PREDICTED: WD repeat-containing protein 52 isoform X2 [Rattus norvegicus]","gi|672071360|ref|XM_008768785.1|",5863,0,"PREDICTED: Rattus norvegicus cilia and flagella associated protein 44 (Cfap44), transcript variant X2, mRNA","Q96MT7",1310,0,"Cilia- and flagella-associated protein 44",".",".",".",".","pfam10174","Cast","RIM-binding protein of the cytomatrix active zone. This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.","GO:0000226|microtubule cytoskeleton organization;GO:0006508|proteolysis;GO:0007288|sperm axoneme assembly;GO:0030317|flagellated sperm motility;GO:0060271|cilium assembly;GO:0060285|cilium-dependent cell motility;",".","GO:0008233|peptidase activity;","K24224","CFAP44, WDR52; cilia- and flagella-associated protein 44"]
["ENSRNOG00000070737",44,3.653173063,14,0.900626135,4.056259221,2.020149853,{"v":7.31495e-07,"d":"7.31E-07"},{"v":1.13443e-06,"d":"1.13E-06"},"up","yes","ENSRNOG00000070737","protein_coding","chr10:82984776-82992334:-","gi|564374390|ref|XP_006247459.1|",394,{"v":1e-39,"d":"1.00E-39"},"PREDICTED: putative ADP-ribosylation factor-like protein 5C isoform X2 [Rattus norvegicus]","gi|298893492|emb|FQ234434.1|",1123,0,"Rattus norvegicus TL0AEA59YA10 mRNA sequence","Q6P068",143,{"v":2e-36,"d":"2.00E-36"},"ADP-ribosylation factor-like protein 5C","YDL192w",78.6,{"v":8e-15,"d":"8.00E-15"},"COG1100","pfam00025","Arf","ADP-ribosylation factor family. Pfam combines a number of different Prosite families together",".",".",".",".","."]
["ENSRNOG00000020332",87,7.223319466,47,3.023530595,2.389034686,1.2564278,{"v":7.63711e-07,"d":"7.64E-07"},{"v":1.18185E-6,"d":"1.18E-06"},"up","yes","Tnnt3","protein_coding","chr1:197652431-197669535:+","gi|149061720|gb|EDM12143.1|",662,{"v":1e-111,"d":"1.00E-111"},"troponin T3, skeletal, fast, isoform CRA_g, partial [Rattus norvegicus]","gi|33354295|gb|AC098563.6|",1277,0,"Rattus norvegicus 1 BAC CH230-123A15 (Children's Hospital Oakland Research Institute) complete sequence","P02641",269,{"v":5e-81,"d":"5.00E-81"},"Troponin T, fast skeletal muscle",".",".",".",".","pfam00992","Troponin","Troponin. Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). this Pfam contains members of the TnT subunit. Troponin is a complex of three proteins, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). The troponin complex regulates Ca++ induced muscle contraction. This family includes troponin T and troponin I. Troponin I binds to actin and troponin T binds to tropomyosin.","GO:0003009|skeletal muscle contraction;GO:0006936|muscle contraction;GO:0006937|regulation of muscle contraction;GO:0006942|regulation of striated muscle contraction;GO:0043462|regulation of ATPase activity;GO:0045214|sarcomere organization;GO:1903612|positive regulation of calcium-dependent ATPase activity;","GO:0005861|troponin complex;","GO:0003779|actin binding;GO:0005523|tropomyosin binding;GO:0030172|troponin C binding;GO:0031013|troponin I binding;GO:0031014|troponin T binding;GO:0048306|calcium-dependent protein binding;","K12046","TNNT3; troponin T, fast skeletal muscle"]
["ENSRNOG00000064524",34,2.822906458,8,0.514643505,5.485168719,2.455535997,{"v":9.22395e-07,"d":"9.22E-07"},{"v":1.41674E-6,"d":"1.42E-06"},"up","yes","ENSRNOG00000064524","protein_coding","chr1:65352351-65359807:+","gi|564325681|ref|XP_006228101.1|",2424,0,"PREDICTED: leukocyte immunoglobulin-like receptor subfamily B member 3 isoform X3 [Rattus norvegicus]","gi|672034732|ref|XM_006228039.2|",920,0,"PREDICTED: Rattus norvegicus leukocyte immunoglobulin-like receptor subfamily B member 3-like (LOC100912456), transcript variant X3, mRNA","A0A0G2KBC9",791,0,"Leukocyte immunoglobulin-like receptor subfamily B member 3-like",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.",".",".",".",".","."]
["ENSRNOG00000045543",114,9.4650393,71,4.567461111,2.072275838,1.051216051,{"v":9.25299e-07,"d":"9.25E-07"},{"v":1.42052e-06,"d":"1.42E-06"},"up","yes","Frat2","protein_coding","chr1:240654137-240656517:-","gi|564333829|ref|XP_006231482.1|",719,{"v":3e-86,"d":"3.00E-86"},"PREDICTED: GSK-3-binding protein FRAT2 [Rattus norvegicus]","gi|46275999|gb|AC145557.3|",1290,0,"Mus musculus BAC clone RP23-313I19 from chromosome 19, complete sequence","Q8K025",239,{"v":7E-72,"d":"7.00E-72"},"GSK-3-binding protein FRAT2",".",".",".",".","pfam05350","GSK-3_bind","Glycogen synthase kinase-3 binding. Glycogen synthase kinase-3 (GSK-3) sequentially phosphorylates four serine residues on glycogen synthase (GS), in the sequence SxxxSxxxSxxx-SxxxS(p), by recognizing and phosphorylating the first serine in the sequence motif SxxxS(P) (where S(p) represents a phosphoserine). Interaction of GSK-3 with a peptide derived from GSK-3 binding protein (this family) prevents GSK-3 interaction with Axin. This interaction thereby inhibits the Axin-dependent phosphorylation of beta-catenin by GSK-3.","GO:0016055|Wnt signaling pathway;","GO:0005737|cytoplasm;",".","K03096","FRAT2; frequently rearranged in advanced T-cell lymphomas 2"]
["ENSRNOG00000026150",59,4.898572971,25,1.608260955,3.045881924,1.606860016,{"v":9.55451e-07,"d":"9.55E-07"},{"v":1.46505e-06,"d":"1.47E-06"},"up","yes","Zar1","protein_coding","chr14:35193446-35197382:-","gi|149035273|gb|EDL89977.1|",1758,0,"zygote arrest 1 [Rattus norvegicus]","gi|31341224|ref|NM_181385.2|",1280,0,"Rattus norvegicus zygote arrest 1 (Zar1), mRNA","Q7TSX9",666,0,"Zygote arrest protein 1",".",".",".",".","pfam13695","zf-3CxxC","Zinc-binding domain. This is a family with several pairs of CxxC motifs possibly representing a multiple zinc-binding region. Only one pair of cysteines is associated with a highly conserved histidine residue.","GO:0000003|reproduction;GO:0006412|translation;GO:0016441|posttranscriptional gene silencing;","GO:0005737|cytoplasm;","GO:1903231|mRNA binding involved in posttranscriptional gene silencing;","K18762","ZAR1; zygote arrest protein 1"]
["ENSRNOG00000005985",106,8.800826016,64,4.117148044,2.137602516,1.095993611,{"v":9.83025E-7,"d":"9.83E-07"},{"v":1.50552e-06,"d":"1.51E-06"},"up","yes","Kcnma1","protein_coding","chr15:302214-1001198:+","gi|13929184|ref|NP_114016.1|",6015,0,"calcium-activated potassium channel subunit alpha-1 [Rattus norvegicus]","gi|13929183|ref|NM_031828.1|",5045,0,"Rattus norvegicus potassium calcium-activated channel subfamily M alpha 1 (Kcnma1), mRNA","Q12791",2255,0,"Calcium-activated potassium channel subunit alpha-1","BS_yugO_2",63.5,{"v":8e-10,"d":"8.00E-10"},"COG1226","pfam03493","BK_channel_a","Calcium-activated BK potassium channel alpha subunit.","GO:0001666|response to hypoxia;GO:0006813|potassium ion transport;GO:0006970|response to osmotic stress;GO:0007268|chemical synaptic transmission;GO:0007568|aging;GO:0007605|sensory perception of sound;GO:0007623|circadian rhythm;GO:0007628|adult walking behavior;GO:0009268|response to pH;GO:0019228|neuronal action potential;GO:0030007|cellular potassium ion homeostasis;GO:0031960|response to corticosteroid;GO:0032344|regulation of aldosterone metabolic process;GO:0034465|response to carbon monoxide;GO:0034765|regulation of ion transmembrane transport;GO:0042311|vasodilation;GO:0042391|regulation of membrane potential;GO:0042491|inner ear auditory receptor cell differentiation;GO:0043065|positive regulation of apoptotic process;GO:0043525|positive regulation of neuron apoptotic process;GO:0043627|response to estrogen;GO:0045475|locomotor rhythm;GO:0045794|negative regulation of cell volume;GO:0046541|saliva secretion;GO:0048469|cell maturation;GO:0050885|neuromuscular process controlling balance;GO:0051592|response to calcium ion;GO:0060073|micturition;GO:0060082|eye blink reflex;GO:0060083|smooth muscle contraction involved in micturition;GO:0060087|relaxation of vascular smooth muscle;GO:0071805|potassium ion transmembrane transport;GO:0097746|regulation of blood vessel diameter;GO:0099505|regulation of presynaptic membrane potential;GO:1902632|positive regulation of membrane hyperpolarization;GO:1904348|negative regulation of small intestine smooth muscle contraction;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0005901|caveola;GO:0008076|voltage-gated potassium channel complex;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0030425|dendrite;GO:0032991|protein-containing complex;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0045211|postsynaptic membrane;GO:0048471|perinuclear region of cytoplasm;GO:0048787|presynaptic active zone membrane;GO:0098978|glutamatergic synapse;GO:0099059|integral component of presynaptic active zone membrane;","GO:0003779|actin binding;GO:0005249|voltage-gated potassium channel activity;GO:0005267|potassium channel activity;GO:0005515|protein binding;GO:0015269|calcium-activated potassium channel activity;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;GO:0046872|metal ion binding;GO:0060072|large conductance calcium-activated potassium channel activity;GO:0099507|ligand-gated ion channel activity involved in regulation of presynaptic membrane potential;","K04936","KCNMA1, KCA1.1; potassium large conductance calcium-activated channel subfamily M alpha member 1"]
["ENSRNOG00000018706",73,6.060946218,36,2.315895775,2.617106644,1.387972714,{"v":1.00538E-6,"d":"1.01E-06"},{"v":1.53829e-06,"d":"1.54E-06"},"up","yes","Il15ra","protein_coding","chr17:66802334-66832278:-","gi|109506139|ref|XP_001069156.1|",1089,{"v":2e-142,"d":"2.00E-142"},"PREDICTED: interleukin-15 receptor subunit alpha isoform X1 [Rattus norvegicus]","gi|672030246|ref|XM_001069156.3|",1404,0,"PREDICTED: Rattus norvegicus interleukin 15 receptor, alpha (Il15ra), transcript variant X1, mRNA","Q60819",322,{"v":2e-104,"d":"2.00E-104"},"Interleukin-15 receptor subunit alpha",".",".",".",".","pfam00084","Sushi","Sushi domain (SCR repeat).","GO:0007259|JAK-STAT cascade;GO:0010977|negative regulation of neuron projection development;GO:0031667|response to nutrient levels;GO:0032825|positive regulation of natural killer cell differentiation;GO:0035723|interleukin-15-mediated signaling pathway;GO:0050766|positive regulation of phagocytosis;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0031410|cytoplasmic vesicle;","GO:0003674|molecular_function;GO:0019901|protein kinase binding;GO:0042010|interleukin-15 receptor activity;","K05074","IL15RA, CD215; interleukin 15 receptor alpha"]
["ENSRNOG00000017939",107,8.883852676,65,4.181478482,2.124572137,1.08717233,{"v":1.02946E-6,"d":"1.03E-06"},{"v":1.57213e-06,"d":"1.57E-06"},"up","yes","Chn1","protein_coding","chr3:58510536-58676490:-","gi|262205420|ref|NP_001106717.2|",2474,0,"N-chimaerin isoform 3 [Mus musculus]","gi|262205419|ref|NM_001113246.2|",2055,0,"Mus musculus chimerin 1 (Chn1), transcript variant 3, mRNA","Q91V57",957,0,"N-chimaerin",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0007165|signal transduction;GO:0008045|motor neuron axon guidance;GO:0035556|intracellular signal transduction;GO:0043087|regulation of GTPase activity;GO:0043547|positive regulation of GTPase activity;GO:0048013|ephrin receptor signaling pathway;GO:0050770|regulation of axonogenesis;GO:0051056|regulation of small GTPase mediated signal transduction;",".","GO:0001565|phorbol ester receptor activity;GO:0005096|GTPase activator activity;GO:0046872|metal ion binding;GO:0046875|ephrin receptor binding;","K20630","CHN1_2, ARHGAP2_3; chimaerin"]
["ENSRNOG00000014953",37,3.071986439,10,0.643304382,4.775323356,2.255598427,{"v":1.12513E-6,"d":"1.13E-06"},{"v":1.70803E-6,"d":"1.71E-06"},"up","yes","Fbxo39","protein_coding","chr10:56932297-56934906:+","gi|537143087|gb|ERE68820.1|",2410,0,"F-box only protein 39 [Cricetulus griseus]","gi|672067930|ref|XM_006246729.2|",1591,0,"PREDICTED: Rattus norvegicus F-box protein 39 (Fbxo39), transcript variant X2, mRNA","Q66H10",919,0,"F-box only protein 39",".",".",".",".","pfam12937","F-box-like","F-box-like. This is an F-box-like family.","GO:0031146|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;","GO:0019005|SCF ubiquitin ligase complex;",".","K10314","FBXO39; F-box protein 39"]
["ENSRNOG00000026518",37,3.071986439,10,0.643304382,4.775323356,2.255598427,{"v":1.12513E-6,"d":"1.13E-06"},{"v":1.70803E-6,"d":"1.71E-06"},"up","yes","Tmem156","protein_coding","chr14:43223381-43252449:+","gi|68341947|ref|NP_001020309.1|",1531,0,"transmembrane protein 156 [Rattus norvegicus]","gi|68341946|ref|NM_001025138.1|",1504,0,"Rattus norvegicus transmembrane protein 156 (Tmem156), mRNA","Q5BK38",594,0,"Transmembrane protein 156",".",".",".",".","pfam15106","TMEM156","TMEM156 protein family. The function of this family of transmembrane proteins, TMEM 156, has not, as yet, been determined. Members of this family are as yet uncharacterized. This family of proteins are found in eukaryotes. Proteins in this family are approximately 310 amino acids in length. In humans, the gene encoding this protein is located in the chromosomal position, 4p14.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000028632",80,6.642132842,42,2.701878404,2.458338922,1.297683828,{"v":1.16126E-6,"d":"1.16E-06"},{"v":1.75953E-6,"d":"1.76E-06"},"up","yes","Bcl2l14","protein_coding","chr4:167219871-167258086:+","gi|66730463|ref|NP_001019509.1|",1495,0,"apoptosis facilitator Bcl-2-like protein 14 [Rattus norvegicus]","gi|672051486|ref|XM_006237533.2|",1510,0,"PREDICTED: Rattus norvegicus Bcl2-like 14 (apoptosis facilitator) (Bcl2l14), transcript variant X1, mRNA","Q6AYK4",580,0,"Apoptosis facilitator Bcl-2-like protein 14",".",".",".",".","pfam00452","Bcl-2","Apoptosis regulator proteins, Bcl-2 family.","GO:0006915|apoptotic process;GO:0008150|biological_process;GO:2001236|regulation of extrinsic apoptotic signaling pathway;GO:2001238|positive regulation of extrinsic apoptotic signaling pathway;","GO:0005575|cellular_component;GO:0005829|cytosol;GO:0043229|intracellular organelle;","GO:0003674|molecular_function;GO:0019901|protein kinase binding;",".","."]
["ENSRNOG00000013330",19,1.57750655,0,0.032165219,49.04386149,5.61600067,{"v":1.22155E-6,"d":"1.22E-06"},{"v":1.84302e-06,"d":"1.84E-06"},"up","yes","Cdhr1","protein_coding","chr16:12843437-12863396:-","gi|17865341|ref|NP_446024.1|",3696,0,"cadherin-related family member 1 precursor [Rattus norvegicus]","gi|17865340|ref|NM_053572.1|",4251,0,"Rattus norvegicus cadherin-related family member 1 (Cdhr1), mRNA","Q91XU7",1428,0,"Cadherin-related family member 1",".",".",".",".","pfam00028","Cadherin","Cadherin domain.","GO:0007155|cell adhesion;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0008150|biological_process;GO:0008594|photoreceptor cell morphogenesis;GO:0009987|cellular process;GO:0035845|photoreceptor cell outer segment organization;GO:0045494|photoreceptor cell maintenance;","GO:0005575|cellular_component;GO:0005887|integral component of plasma membrane;GO:0042622|photoreceptor outer segment membrane;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;","K16501","CDHR1, PCDH21; cadherin-related family member 1"]
["ENSRNOG00000042581",19,1.57750655,0,0.032165219,49.04386149,5.61600067,{"v":1.22155E-6,"d":"1.22E-06"},{"v":1.84302e-06,"d":"1.84E-06"},"up","yes","Ptcra","protein_coding","chr9:14218802-14229235:+","gi|182636672|sp|P0C6B3.1|PTCRA_RAT",764,{"v":9e-96,"d":"9.00E-96"},"RecName: Full=Pre T-cell antigen receptor alpha; Short=pT-alpha; Short=pTa; AltName: Full=pT-alpha-TCR; Flags: Precursor","gi|672023741|ref|XM_001065627.3|",860,0,"PREDICTED: Rattus norvegicus pre T-cell antigen receptor alpha (Ptcra), transcript variant X2, mRNA","P0C6B3",298,{"v":3e-97,"d":"3.00E-97"},"Pre T-cell antigen receptor alpha",".",".",".",".","pfam15028","PTCRA","Pre-T-cell antigen receptor. The pre-T-cell antigen receptor (pre-TCR), expressed by immature thymocytes, has a pivotal role in early T-cell development, including TCR beta-selection, survival and proliferation of CD4(-)CD8(-) double-negative thymocytes, and subsequent alpha/beta T-cell lineage differentiation. This protein contains an immunoglobulin domain.","GO:0070244|negative regulation of thymocyte apoptotic process;","GO:0016021|integral component of membrane;",".","K06056","PTCRA; pre T-cell antigen receptor alpha"]
["ENSRNOG00000054129",19,1.57750655,0,0.032165219,49.04386149,5.61600067,{"v":1.22155E-6,"d":"1.22E-06"},{"v":1.84302e-06,"d":"1.84E-06"},"up","yes","Ctla4","protein_coding","chr9:62319312-62324963:+","gi|149046030|gb|EDL98923.1|",1186,{"v":2e-162,"d":"2.00E-162"},"cytotoxic T-lymphocyte-associated protein 4, isoform CRA_a [Rattus norvegicus]","gi|13928933|ref|NM_031674.1|",715,0,"Rattus norvegicus cytotoxic T-lymphocyte-associated protein 4 (Ctla4), mRNA","P09793",417,{"v":1E-146,"d":"1.00E-146"},"Cytotoxic T-lymphocyte protein 4",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0006955|immune response;GO:0006974|cellular response to DNA damage stimulus;GO:0030889|negative regulation of B cell proliferation;GO:0042130|negative regulation of T cell proliferation;GO:0043065|positive regulation of apoptotic process;GO:0045590|negative regulation of regulatory T cell differentiation;GO:0050777|negative regulation of immune response;GO:0050852|T cell receptor signaling pathway;GO:0050853|B cell receptor signaling pathway;","GO:0005575|cellular_component;GO:0005794|Golgi apparatus;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0045334|clathrin-coated endocytic vesicle;GO:0048471|perinuclear region of cytoplasm;GO:0098636|protein complex involved in cell adhesion;","GO:0005515|protein binding;GO:0038023|signaling receptor activity;","K06538","CTLA4, CD152; cytotoxic T-lymphocyte-associated protein 4"]
["ENSRNOG00000070677",19,1.57750655,0,0.032165219,49.04386149,5.61600067,{"v":1.22155E-6,"d":"1.22E-06"},{"v":1.84302e-06,"d":"1.84E-06"},"up","yes","ENSRNOG00000070677","protein_coding","chr12:18516156-18525346:+","gi|564378700|ref|XP_006249121.1|",1086,{"v":2E-140,"d":"2.00E-140"},"PREDICTED: paired immunoglobulin-like type 2 receptor beta isoform X1 [Rattus norvegicus]","gi|672072515|ref|XR_595294.1|",1193,0,"PREDICTED: Rattus norvegicus similar to paired immunoglobin-like type 2 receptor beta (LOC681341), transcript variant X7, misc_RNA","Q2YFS2",308,{"v":9e-98,"d":"9.00E-98"},"Paired immunoglobulin-like type 2 receptor beta",".",".",".",".","pfam14329","DUF4386","Domain of unknown function (DUF4386). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 214 and 245 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000053430",30,2.490799816,6,0.385982629,6.45313967,2.690001251,{"v":1.24147e-06,"d":"1.24E-06"},{"v":1.86956E-6,"d":"1.87E-06"},"up","yes","Slco4a1","protein_coding","chr3:167559316-167578305:+","gi|67514562|ref|NP_598292.2|",3194,0,"solute carrier organic anion transporter family member 4A1 [Rattus norvegicus]","gi|67514561|ref|NM_133608.2|",2964,0,"Rattus norvegicus solute carrier organic anion transporter family, member 4a1 (Slco4a1), mRNA","Q99N01",1229,0,"Solute carrier organic anion transporter family member 4A1",".",".",".",".","pfam03137","OATP","Organic Anion Transporter Polypeptide (OATP) family. This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.","GO:0006811|ion transport;GO:0042403|thyroid hormone metabolic process;GO:0043252|sodium-independent organic anion transport;GO:0055085|transmembrane transport;GO:0070327|thyroid hormone transport;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;","GO:0015347|sodium-independent organic anion transmembrane transporter activity;GO:0015349|thyroid hormone transmembrane transporter activity;GO:0022857|transmembrane transporter activity;","K14354","SLCO4A; solute carrier organic anion transporter family, member 4A"]
["ENSRNOG00000028259",40,3.321066421,12,0.771965258,4.302093113,2.10503875,{"v":1.24148E-6,"d":"1.24E-06"},{"v":1.86956E-6,"d":"1.87E-06"},"up","yes","Mcemp1","protein_coding","chr12:1718730-1725986:+","gi|672072052|ref|XP_008767209.1|",1405,0,"PREDICTED: mast cell-expressed membrane protein 1 isoform X1 [Rattus norvegicus]","gi|672072051|ref|XM_008768987.1|",1429,0,"PREDICTED: Rattus norvegicus mast cell-expressed membrane protein 1 (Mcemp1), transcript variant X1, mRNA","Q9D8U6",262,{"v":9e-83,"d":"9.00E-83"},"Mast cell-expressed membrane protein 1",".",".",".",".","pfam03954","Lectin_N","Hepatic lectin, N-terminal domain.",".","GO:0016021|integral component of membrane;","GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000052649",43,3.570146403,14,0.900626135,3.964071511,1.986982989,{"v":1.27523e-06,"d":"1.28E-06"},{"v":1.91812E-6,"d":"1.92E-06"},"up","yes","AABR07008309.1","lncRNA","chr2:52006086-52027865:+",".",".",".",".","gi|672041664|ref|XR_590927.1|",589,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103691468 (LOC103691468), transcript variant X2, ncRNA",".",".",".",".",".",".",".",".","pfam10032","Pho88","Phosphate transport (Pho88). Members of this family of proteins are involved in regulating inorganic phosphate transport, as well as telomere length regulation and maintenance.",".",".",".",".","."]
["ENSRNOG00000037275",61,5.064626292,27,1.736921831,2.91586311,1.543922992,{"v":1.29644E-6,"d":"1.30E-06"},{"v":1.94838e-06,"d":"1.95E-06"},"up","yes","Tlcd2","protein_coding","chr10:60311099-60313622:+","gi|392331811|ref|XP_001080690.3|",1158,{"v":2e-156,"d":"2.00E-156"},"PREDICTED: TLC domain-containing protein 2 isoform X1 [Rattus norvegicus]","gi|672024947|ref|XM_001080690.5|",944,0,"PREDICTED: Rattus norvegicus TLC domain containing 2 (Tlcd2), transcript variant X1, mRNA","Q8VC26",364,{"v":1e-123,"d":"1.00E-123"},"TLC domain-containing protein 2",".",".",".",".","pfam03798","TRAM_LAG1_CLN8","TLC domain.","GO:0007009|plasma membrane organization;GO:0055088|lipid homeostasis;GO:0055091|phospholipid homeostasis;GO:0071709|membrane assembly;GO:0097035|regulation of membrane lipid distribution;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000067887",61,5.064626292,27,1.736921831,2.91586311,1.543922992,{"v":1.29644E-6,"d":"1.30E-06"},{"v":1.94838e-06,"d":"1.95E-06"},"up","yes","ENSRNOG00000067887","lncRNA","chr7:12622899-12623905:+",".",".",".",".","gi|195540031|gb|BC168190.1|",939,0,"Rattus norvegicus cDNA clone IMAGE:7106560",".",".",".",".",".",".",".",".","pfam07778","CENP-I","Mis6. Mis6 is an essential centromere connector protein acting during G1-S phase of the cell cycle. Mis6 is thought to be required for recruiting CENP-A, the centromere- specific histone H3 variant, an important event for centromere function and chromosome segregation during mitosis.",".",".",".",".","."]
["ENSRNOG00000010454",107,8.883852676,66,4.24580892,2.092381651,1.065146023,{"v":1.54568E-6,"d":"1.55E-06"},{"v":2.30271e-06,"d":"2.30E-06"},"up","yes","ENSRNOG00000010454","protein_coding","chr2:44626369-44633914:+","gi|564335285|ref|XP_006232009.1|",1594,0,"PREDICTED: cyclin-O isoform X1 [Rattus norvegicus]","gi|672041484|ref|XM_006231947.2|",3540,0,"PREDICTED: Rattus norvegicus cyclin O (Ccno), transcript variant X1, mRNA","P0C242",565,0,"Cyclin-O",".",".",".",".","pfam00134","Cyclin_N","Cyclin, N-terminal domain. Cyclins regulate cyclin dependent kinases (CDKs). Human cyclin-O is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.","GO:0000079|regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0000278|mitotic cell cycle;GO:0009410|response to xenobiotic stimulus;GO:0044772|mitotic cell cycle phase transition;GO:0060271|cilium assembly;GO:1903251|multi-ciliated epithelial cell differentiation;","GO:0000307|cyclin-dependent protein kinase holoenzyme complex;GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0097124|cyclin A2-CDK2 complex;","GO:0003674|molecular_function;GO:0016538|cyclin-dependent protein serine/threonine kinase regulator activity;","K10861","UDG2, CCNO; uracil-DNA glycosylase 2 [EC:3.2.2.-]"]
["ENSRNOG00000018316",44,3.653173063,15,0.964956573,3.78584194,1.920614179,{"v":1.662e-06,"d":"1.66E-06"},{"v":2.46509e-06,"d":"2.47E-06"},"up","yes","Grap2","protein_coding","chr7:112117142-112190877:+","gi|77917586|ref|NP_001030116.1|",1077,{"v":1e-138,"d":"1.00E-138"},"GRB2-related adapter protein 2 [Rattus norvegicus]","gi|77917585|ref|NM_001034944.1|",812,0,"Rattus norvegicus GRB2-related adaptor protein 2 (Grap2), mRNA","O89100",377,{"v":6E-124,"d":"6.00E-124"},"GRB2-related adaptor protein 2",".",".",".",".","pfam00017","SH2","SH2 domain.",".",".",".",".","."]
["ENSRNOG00000006784",33,2.739879797,8,0.514643505,5.323840228,2.412467276,{"v":1.70489e-06,"d":"1.70E-06"},{"v":2.52519e-06,"d":"2.53E-06"},"up","yes","Sema4f","protein_coding","chr4:115411417-115437721:-","gi|9507083|ref|NP_062145.1|",3424,0,"semaphorin-4F precursor [Rattus norvegicus]","gi|9507082|ref|NM_019272.1|",3973,0,"Rattus norvegicus ssemaphorin 4F (Sema4f), mRNA","Q9Z143",1323,0,"Semaphorin-4F",".",".",".",".","pfam01403","Sema","Sema domain. The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and human plexin A-3.","GO:0001755|neural crest cell migration;GO:0007411|axon guidance;GO:0030335|positive regulation of cell migration;GO:0030517|negative regulation of axon extension;GO:0031290|retinal ganglion cell axon guidance;GO:0048843|negative regulation of axon extension involved in axon guidance;GO:0050919|negative chemotaxis;GO:0071526|semaphorin-plexin signaling pathway;","GO:0005615|extracellular space;GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0014069|postsynaptic density;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0043204|perikaryon;GO:0045202|synapse;GO:0045211|postsynaptic membrane;","GO:0030215|semaphorin receptor binding;GO:0045499|chemorepellent activity;","K06521","SEMA4, CD100; semaphorin 4"]
["ENSRNOG00000009030",63,5.230679613,29,1.865582707,2.803777925,1.487372085,{"v":1.70561e-06,"d":"1.71E-06"},{"v":2.52568e-06,"d":"2.53E-06"},"up","yes","Rab19","protein_coding","chr4:68156881-68166886:+","gi|66730270|ref|NP_001019497.1|",1142,{"v":9e-152,"d":"9.00E-152"},"ras-related protein Rab-19 [Rattus norvegicus]","gi|66730269|ref|NM_001024326.1|",1336,0,"Rattus norvegicus RAB19, member RAS oncogene family (Rab19), mRNA","Q5M7U5",444,{"v":3E-153,"d":"3.00E-153"},"Ras-related protein Rab-19",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0000045|autophagosome assembly;GO:0006886|intracellular protein transport;","GO:0005886|plasma membrane;GO:0012505|endomembrane system;","GO:0003924|GTPase activity;GO:0005525|GTP binding;","K17047","RAB19; Ras-related protein Rab-19"]
["ENSRNOG00000022603",80,6.642132842,43,2.766208842,2.401168249,1.263736496,{"v":1.9085E-6,"d":"1.91E-06"},{"v":2.80597e-06,"d":"2.81E-06"},"up","yes","Astl","protein_coding","chr3:114563135-114578868:+","gi|157817618|ref|NP_001099974.1|",1957,0,"astacin-like metalloendopeptidase precursor [Rattus norvegicus]","gi|157817617|ref|NM_001106504.1|",2227,0,"Rattus norvegicus astacin-like metalloendopeptidase (M12 family) (Astl), mRNA","Q6HA09",685,0,"Astacin-like metalloendopeptidase",".",".",".",".","pfam01400","Astacin","Astacin (Peptidase family M12A). The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family contain two conserved disulphide bridges, these are joined 1-4 and 2-3. Members of this family have an amino terminal propeptide which is cleaved to give the active protease domain. All other linked domains are found to the carboxyl terminus of this domain. This family includes: Astacin, a digestive enzyme from Crayfish. Meprin, a multiple domain membrane component that is constructed from a homologous alpha and beta chain. Proteins involved in morphogenesis, and Tolloid from drosophila.","GO:0006508|proteolysis;GO:0007155|cell adhesion;GO:0009566|fertilization;GO:0010954|positive regulation of protein processing;GO:0060468|prevention of polyspermy;GO:2000360|negative regulation of binding of sperm to zona pellucida;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0060473|cortical granule;","GO:0004222|metalloendopeptidase activity;GO:0008233|peptidase activity;GO:0008270|zinc ion binding;GO:0070001|aspartic-type peptidase activity;GO:0070002|glutamic-type peptidase activity;","K08778","ASTL; astacin-like metalloendopeptidase [EC:3.4.-.-]"]
["ENSRNOG00000011228",95,7.88753275,56,3.602504538,2.189458102,1.130573842,{"v":2.01698e-06,"d":"2.02E-06"},{"v":2.96137e-06,"d":"2.96E-06"},"up","yes","Layn","protein_coding","chr8:51367091-51384330:-","gi|564363657|ref|XP_006243111.1|",1850,0,"PREDICTED: layilin isoform X1 [Rattus norvegicus]","gi|672062204|ref|XM_006243049.2|",1217,0,"PREDICTED: Rattus norvegicus layilin (Layn), transcript variant X1, mRNA","Q8C351",611,0,"Layilin",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type",".","GO:0016021|integral component of membrane;","GO:0005540|hyaluronic acid binding;","K10077","LAYN; layilin"]
["ENSRNOG00000048004",31,2.573826476,7,0.450313067,5.715637993,2.514914545,{"v":2.03227E-6,"d":"2.03E-06"},{"v":2.9804e-06,"d":"2.98E-06"},"up","yes","Garem2","protein_coding","chr6:26230048-26241762:-","gi|300798228|ref|NP_001178803.1|",3267,0,"GRB2-associated and regulator of MAPK protein-like [Rattus norvegicus]","gi|300798227|ref|NM_001191874.1|",2662,0,"Rattus norvegicus GRB2 associated regulator of MAPK1, member 2 (Garem2), mRNA",".",".",".",".",".",".",".",".","pfam12736","CABIT","Cell-cycle sustaining, positive selection,. The 'CABIT' domain (for 'cysteine-containing, all- in Themis') is found in a newly identified gene family that has three mammalian homologues (Themis, Icb1 and 9130404H23Rik) that encode proteins with two CABIT domains and a highly conserved proline-rich region. In contrast, Fam59A, Fam59B and related proteins from mammals to cnidarians, including the insect Serrano proteins, have a single copy of the CABIT domain, a proline-rich region and often a C-terminal SAM (sterile-motif) domain. Multiple-sequence alignment has predicted that the CABIT domain adopts an all-strand structure with at least 12 strands, ie a dyad of six-stranded beta-barrel units. The CABIT domain contains a nearly absolutely conserved cysteine residue which is likely to be central to its function. CABIT domain proteins function downstream of tyrosine kinase signalling and interact with GRB2.",".",".",".",".","."]
["ENSRNOG00000066649",42,3.487119742,14,0.900626135,3.871883802,1.953035657,{"v":2.21334e-06,"d":"2.21E-06"},{"v":3.2326e-06,"d":"3.23E-06"},"up","yes","ENSRNOG00000066649","lncRNA","chr18:21929982-21932444:-",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","pfam04293","SpoVR","SpoVR like protein. Bacillus subtilis stage V sporulation protein R is involved in spore cortex formation. Little is known about cortex biosynthesis, except that it depends on several sigma E controlled genes, including spoVR.",".",".",".",".","."]
["ENSRNOG00000007490",29,2.407773155,6,0.385982629,6.238035014,2.641091651,{"v":2.35197e-06,"d":"2.35E-06"},{"v":3.42646e-06,"d":"3.43E-06"},"up","yes","Gabrr2","protein_coding","chr5:47452150-47489809:+","gi|149045578|gb|EDL98578.1|",2488,0,"rCG55020, isoform CRA_a [Rattus norvegicus]","gi|402691997|ref|NM_017292.2|",1757,0,"Rattus norvegicus gamma-aminobutyric acid type A receptor rho 2 subunit (Gabrr2), mRNA","P47742",941,0,"Gamma-aminobutyric acid receptor subunit rho-2",".",".",".",".","pfam02931","Neur_chan_LBD","Neurotransmitter-gated ion-channel ligand binding domain. This family is the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.","GO:0006821|chloride transport;GO:0007165|signal transduction;GO:0007214|gamma-aminobutyric acid signaling pathway;GO:0007268|chemical synaptic transmission;GO:0007601|visual perception;GO:0034220|ion transmembrane transport;GO:0042391|regulation of membrane potential;GO:0050877|nervous system process;GO:0060078|regulation of postsynaptic membrane potential;GO:1902476|chloride transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0034707|chloride channel complex;GO:0043005|neuron projection;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0098982|GABA-ergic synapse;GO:1902711|GABA-A receptor complex;","GO:0004890|GABA-A receptor activity;GO:0005230|extracellular ligand-gated ion channel activity;GO:0005237|inhibitory extracellular ligand-gated ion channel activity;GO:0005254|chloride channel activity;GO:0019904|protein domain specific binding;GO:0030594|neurotransmitter receptor activity;GO:1904315|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K05190","GABRR; gamma-aminobutyric acid receptor subunit rho"]
["ENSRNOG00000067295",18,1.494479889,0,0.032165219,46.46260562,5.537998158,{"v":2.35291e-06,"d":"2.35E-06"},{"v":3.42705e-06,"d":"3.43E-06"},"up","yes","ENSRNOG00000067295","protein_coding","chr4:70045190-70046009:+","gi|149065376|gb|EDM15452.1|",547,{"v":3e-69,"d":"3.00E-69"},"rCG27868, partial [Rattus norvegicus]","gi|207205|gb|M23887.1|RATTCBVG",286,{"v":1E-146,"d":"1.00E-146"},"Rat T-cell receptor beta-chain mRNA V-region (V-D-J-C), clone CRTB39","P04435",82.8,{"v":3e-19,"d":"3.00E-19"},"T cell receptor beta variable 7-9",".",".",".",".","pfam11465","Receptor_2B4","Natural killer cell receptor 2B4. 2B4 is a transmembrane receptor which is expressed primarily on natural killer cells. It plays a role in activating NK-mediated cytotoxicity through its interaction with CD48 on target cells in a subset of CD8 T cells. The structure of 2B4 consists of an immunoglobulin variable domain fold and contains two beta-sheets. One of the beta-sheets, the six-stranded sheet, contains structural features that may have a role in ligand recognition and receptor function.",".",".",".",".","."]
["ENSRNOG00000059073",21,1.743559871,2,0.128660876,13.55159331,3.760390579,{"v":2.46442e-06,"d":"2.46E-06"},{"v":3.57724e-06,"d":"3.58E-06"},"up","yes","Slamf1","protein_coding","chr13:84270316-84305497:+","gi|157818637|ref|NP_001102548.1|",1766,0,"signaling lymphocytic activation molecule precursor [Rattus norvegicus]","gi|157818636|ref|NM_001109078.1|",2731,0,"Rattus norvegicus signaling lymphocytic activation molecule family member 1 (Slamf1), mRNA","Q9QUM4",540,0,"Signaling lymphocytic activation molecule",".",".",".",".","pfam06214","SLAM","Signaling lymphocytic activation molecule (SLAM) protein. This family consists of several mammalian signaling lymphocytic activation molecule (SLAM) proteins. Optimal T cell activation and expansion require engagement of the TCR plus co-stimulatory signals delivered through accessory molecules. SLAM, a 70-kDa co-stimulatory molecule belonging to the Ig superfamily, is defined as a human cell surface molecule that mediates CD28-independent proliferation of human T cells and IFN-gamma production by human Th1 and Th2 clones. SLAM has also been recognized as a receptor for measles virus.","GO:0001779|natural killer cell differentiation;GO:0001787|natural killer cell proliferation;GO:0002232|leukocyte chemotaxis involved in inflammatory response;GO:0002277|myeloid dendritic cell activation involved in immune response;GO:0002725|negative regulation of T cell cytokine production;GO:0010759|positive regulation of macrophage chemotaxis;GO:0031338|regulation of vesicle fusion;GO:0032689|negative regulation of interferon-gamma production;GO:0032695|negative regulation of interleukin-12 production;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032729|positive regulation of interferon-gamma production;GO:0042104|positive regulation of activated T cell proliferation;GO:0046330|positive regulation of JNK cascade;GO:0050790|regulation of catalytic activity;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:2000349|negative regulation of CD40 signaling pathway;GO:2000510|positive regulation of dendritic cell chemotaxis;GO:2000556|positive regulation of T-helper 1 cell cytokine production;","GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0045335|phagocytic vesicle;","GO:0038023|signaling receptor activity;GO:0042169|SH2 domain binding;GO:0042802|identical protein binding;","K06536","SLAMF1, CD150; signaling lymphocytic activation molecule family member 1"]
["ENSRNOG00000026979",92,7.638452768,54,3.473843662,2.198847591,1.13674761,{"v":2.64535E-6,"d":"2.65E-06"},{"v":3.82166e-06,"d":"3.82E-06"},"up","yes","AABR07069466.1","protein_coding","chr8:20921244-20971069:+","gi|672022611|ref|XP_008774890.1|",2500,0,"PREDICTED: uncharacterized protein KIAA0895 homolog isoform X4 [Rattus norvegicus]","gi|672022610|ref|XM_008776668.1|",4258,0,"PREDICTED: Rattus norvegicus similar to RIKEN cDNA 9530077C05 (RGD1561444), transcript variant X4, mRNA",".",".",".",".",".",".",".",".","pfam08014","DUF1704","Domain of unknown function (DUF1704). This family contains many hypothetical proteins.",".",".",".",".","."]
["ENSRNOG00000010347",23,1.909613192,3,0.192991315,9.89481416,3.306672612,{"v":2.73158e-06,"d":"2.73E-06"},{"v":3.93823e-06,"d":"3.94E-06"},"up","yes","Styk1","protein_coding","chr4:165048440-165096440:-","gi|672018833|ref|XP_008774081.1|",2048,0,"PREDICTED: tyrosine-protein kinase STYK1 isoform X2 [Rattus norvegicus]","gi|672018834|ref|XM_008775860.1|",1854,0,"PREDICTED: Rattus norvegicus serine/threonine/tyrosine kinase 1 (Styk1), transcript variant X3, mRNA","Q6J9G1",736,0,"Tyrosine-protein kinase STYK1","YAR019c",80.9,{"v":6e-15,"d":"6.00E-15"},"COG0515","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0030154|cell differentiation;GO:0045087|innate immune response;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;","GO:0004713|protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0005102|signaling receptor binding;GO:0005524|ATP binding;","K17510","STYK1; tyrosine-protein kinase STYK1 [EC:2.7.10.2]"]
["ENSRNOG00000064728",93,7.721479429,55,3.5381741,2.182334507,1.125872254,{"v":2.7901e-06,"d":"2.79E-06"},{"v":4.01896e-06,"d":"4.02E-06"},"up","yes","ENSRNOG00000064728","lncRNA","chr7:52119551-52120658:+","gi|12855414|dbj|BAB30329.1|",153,2E-8,"unnamed protein product [Mus musculus]","gi|259089668|gb|AC136025.3|",1104,0,"Rattus norvegicus CH230-236M3 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam05956","APC_basic","APC basic domain. This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.",".",".",".",".","."]
["ENSRNOG00000038202",43,3.570146403,15,0.964956573,3.699800077,1.887447315,{"v":2.85494e-06,"d":"2.85E-06"},{"v":4.10958e-06,"d":"4.11E-06"},"up","yes","Calml4","protein_coding","chr8:63323351-63335234:+","gi|148694085|gb|EDL26032.1|",895,{"v":5e-118,"d":"5.00E-118"},"calmodulin-like 4, isoform CRA_c [Mus musculus]","gi|189011706|ref|NM_001127575.1|",896,0,"Rattus norvegicus calmodulin-like 4 (Calml4), mRNA","Q91WQ9",311,{"v":5e-105,"d":"5.00E-105"},"Calmodulin-like protein 4","SPAC3A12.14",116,{"v":3e-30,"d":"3.00E-30"},"COG5126","pfam13499","EF-hand_7","EF-hand domain pair.","GO:0050790|regulation of catalytic activity;",".","GO:0005509|calcium ion binding;GO:0030234|enzyme regulator activity;","K02183","CALM; calmodulin"]
["ENSRNOG00000066596",50,4.151333026,20,1.286608764,3.226569835,1.690001251,{"v":2.91215e-06,"d":"2.91E-06"},{"v":4.18628e-06,"d":"4.19E-06"},"up","yes","ENSRNOG00000066596","lncRNA","chr16:18332870-18333956:+",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","pfam14800","DUF4481","Domain of unknown function (DUF4481).",".",".",".",".","."]
["ENSRNOG00000050804",40,3.321066421,13,0.836295696,3.971162874,1.989561533,{"v":2.93192E-6,"d":"2.93E-06"},{"v":4.21376E-6,"d":"4.21E-06"},"up","yes","Zfp353","protein_coding","chr5:105075075-105076667:-","gi|564351653|ref|XP_233185.6|",2865,0,"PREDICTED: uncharacterized protein Zfp353 [Rattus norvegicus]","gi|672053097|ref|XM_233185.7|",1593,0,"PREDICTED: Rattus norvegicus zinc finger protein 353 (Zfp353), mRNA","Q9EPW2",105,{"v":3E-23,"d":"3.00E-23"},"Krueppel-like factor 15",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0006357|regulation of transcription by RNA polymerase II;",".","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;",".","."]
["ENSRNOG00000027833",104,8.634772695,65,4.181478482,2.065004694,1.046145061,{"v":3.03804e-06,"d":"3.04E-06"},{"v":4.36039e-06,"d":"4.36E-06"},"up","yes","Fnip2","protein_coding","chr2:164598906-164707901:-","gi|672042703|ref|XP_008759321.1|",5754,0,"PREDICTED: folliculin-interacting protein 2 isoform X1 [Rattus norvegicus]","gi|672042702|ref|XM_008761099.1|",5543,0,"PREDICTED: Rattus norvegicus folliculin interacting protein 2 (Fnip2), transcript variant X1, mRNA","Q80TD3",1870,0,"Folliculin-interacting protein 2",".",".",".",".","pfam14637","FNIP_M","Folliculin-interacting protein middle domain. This is the middle domain of folliculin-interacting proteins.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001932|regulation of protein phosphorylation;GO:0006468|protein phosphorylation;GO:0008285|negative regulation of cell proliferation;GO:0008630|intrinsic apoptotic signaling pathway in response to DNA damage;GO:0031334|positive regulation of protein complex assembly;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0043086|negative regulation of catalytic activity;","GO:0005737|cytoplasm;GO:0005765|lysosomal membrane;GO:0005829|cytosol;GO:0034451|centriolar satellite;","GO:0042030|ATPase inhibitor activity;GO:0051087|chaperone binding;","K20401","FNIP2; folliculin-interacting protein 2"]
["ENSRNOG00000031726",105,8.717799355,66,4.24580892,2.053271713,1.037924554,{"v":3.156e-06,"d":"3.16E-06"},{"v":4.51753e-06,"d":"4.52E-06"},"up","yes","Oas1e","protein_coding","chr12:35750359-35759301:+","gi|57222312|ref|NP_001009492.1|",1941,0,"2'-5' oligoadenylate synthetase 1E [Rattus norvegicus]","gi|57222311|ref|NM_001009492.1|",1667,0,"Rattus norvegicus 2'-5' oligoadenylate synthetase 1E (Oas1e), mRNA","Q8VI95",533,0,"Inactive 2'-5'-oligoadenylate synthase 1D",".",".",".",".","pfam10421","OAS1_C","2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus. This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between 320 and 344 at the extreme C-terminal end. Oligoadenylate synthetases are antiviral enzymes that counteract vial attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesize 2'.5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication. This domain is often associated with NTP_transf_2 pfam01909.","GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0051607|defense response to virus;GO:0060700|regulation of ribonuclease activity;","GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0016020|membrane;","GO:0003725|double-stranded RNA binding;",".","."]
["ENSRNOG00000002917",41,3.404093082,14,0.900626135,3.779696092,1.918270239,{"v":3.82392e-06,"d":"3.82E-06"},{"v":5.42501e-06,"d":"5.43E-06"},"up","yes","Sec14l5","protein_coding","chr10:10396878-10435917:-","gi|564370548|ref|XP_006245845.1|",3503,0,"PREDICTED: SEC14-like protein 5 isoform X1 [Rattus norvegicus]","gi|672066525|ref|XM_006245783.2|",3029,0,"PREDICTED: Rattus norvegicus SEC14-like 5 (S. cerevisiae) (Sec14l5), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam04707","PRELI","PRELI-like family. This family includes a conserved region found in the PRELI protein and yeast YLR168C gene MSF1 product. The function of this protein is unknown, though it is thought to be involved in intra-mitochondrial protein sorting. This region is also found in a number of other eukaryotic proteins.",".",".",".",".","."]
["ENSRNOG00000006736",17,1.411453229,0,0.032165219,43.88134975,5.455535997,{"v":4.55702e-06,"d":"4.56E-06"},{"v":6.41666e-06,"d":"6.42E-06"},"up","yes","Ccr3","protein_coding","chr8:123616236-123634990:+","gi|16758844|ref|NP_446410.1|",1754,0,"C-C chemokine receptor type 3 [Rattus norvegicus]","gi|672063786|ref|XM_006244178.2|",3049,0,"PREDICTED: Rattus norvegicus chemokine (C-C motif) receptor 3 (Ccr3), transcript variant X1, mRNA","O54814",679,0,"C-C chemokine receptor type 3",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001938|positive regulation of endothelial cell proliferation;GO:0002551|mast cell chemotaxis;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0019722|calcium-mediated signaling;GO:0035476|angioblast cell migration;GO:0045766|positive regulation of angiogenesis;GO:0048245|eosinophil chemotaxis;GO:0060326|cell chemotaxis;GO:0070098|chemokine-mediated signaling pathway;GO:0070371|ERK1 and ERK2 cascade;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0004950|chemokine receptor activity;GO:0016493|C-C chemokine receptor activity;GO:0019957|C-C chemokine binding;","K04178","CCR3, CD193; C-C chemokine receptor type 3"]
["ENSRNOG00000024181",17,1.411453229,0,0.032165219,43.88134975,5.455535997,{"v":4.55702e-06,"d":"4.56E-06"},{"v":6.41666e-06,"d":"6.42E-06"},"up","yes","Tpsab1","protein_coding","chr10:14360396-14362811:-","gi|194239635|ref|NP_062195.2|",1571,0,"tryptase precursor [Rattus norvegicus]","gi|194239634|ref|NM_019322.2|",1224,0,"Rattus norvegicus tryptase alpha/beta 1 (Tpsab1), mRNA","P27435",535,0,"Tryptase","VC1649",124,{"v":2e-30,"d":"2.00E-30"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;GO:0022617|extracellular matrix disassembly;","GO:0005615|extracellular space;GO:0042629|mast cell granule;","GO:0004252|serine-type endopeptidase activity;GO:0008233|peptidase activity;GO:0042802|identical protein binding;","K01340","E3.4.21.59; tryptase [EC:3.4.21.59]"]
["ENSRNOG00000064228",49,4.068306366,20,1.286608764,3.162038438,1.660854905,{"v":4.80549e-06,"d":"4.81E-06"},{"v":6.75017e-06,"d":"6.75E-06"},"up","yes","ENSRNOG00000064228","protein_coding","chr12:18601158-18651608:-","gi|672072527|ref|XP_008767320.1|",963,{"v":2e-161,"d":"2.00E-161"},"PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein RGD1560262 isoform X2 [Rattus norvegicus]","gi|672033567|ref|XM_006227151.2|",1118,0,"PREDICTED: Rattus norvegicus similar to paired immunoglobin-like type 2 receptor beta (RGD1563400), transcript variant X2, mRNA","Q2YFS2",276,{"v":5e-82,"d":"5.00E-82"},"Paired immunoglobulin-like type 2 receptor beta",".",".",".",".","pfam02994","Transposase_22","L1 transposable element.",".",".",".",".","."]
["ENSRNOG00000027278",96,7.97055941,59,3.795495853,2.100004774,1.070392608,{"v":4.8818e-06,"d":"4.88E-06"},{"v":6.84684e-06,"d":"6.85E-06"},"up","yes","Pramef8","protein_coding","chr5:155778201-155793932:+","gi|209413784|ref|NP_001129254.1|",2351,0,"PRAME family member 8 [Rattus norvegicus]","gi|209413783|ref|NM_001135782.1|",1639,0,"Rattus norvegicus PRAME family member 8 (Pramef8), mRNA","Q5VWM4",367,{"v":1e-114,"d":"1.00E-114"},"PRAME family member 8",".",".",".",".","pfam10337","DUF2422","Protein of unknown function (DUF2422). This is a family of proteins conserved in fungi. The function is not known. This family is the C-terminal half of some member proteins which contain the DUF2421 pfam10334 domain at their N-terminus.","GO:0008284|positive regulation of cell proliferation;GO:0043066|negative regulation of apoptotic process;GO:0045596|negative regulation of cell differentiation;GO:0045892|negative regulation of transcription, DNA-templated;","GO:0005737|cytoplasm;",".",".","."]
["ENSRNOG00000019851",20,1.66053321,2,0.128660876,12.90627934,3.690001251,{"v":4.95174e-06,"d":"4.95E-06"},{"v":6.93732e-06,"d":"6.94E-06"},"up","yes","Cox6a2","protein_coding","chr1:182788528-182789274:-","gi|158517820|ref|NP_036944.2|",514,{"v":3e-64,"d":"3.00E-64"},"cytochrome c oxidase subunit 6A2, mitochondrial precursor [Rattus norvegicus]","gi|564330898|ref|XM_006230218.1|",475,0,"PREDICTED: Rattus norvegicus cytochrome c oxidase subunit VIa polypeptide 2 (Cox6a2), transcript variant X1, mRNA","P10817",196,{"v":2e-63,"d":"2.00E-63"},"Cytochrome c oxidase subunit 6A2, mitochondrial (Fragment)",".",".",".",".","pfam02046","COX6A","Cytochrome c oxidase subunit VIa.","GO:0006119|oxidative phosphorylation;GO:0006123|mitochondrial electron transport, cytochrome c to oxygen;GO:0022900|electron transport chain;GO:0050790|regulation of catalytic activity;GO:1902600|proton transmembrane transport;","GO:0005751|mitochondrial respiratory chain complex IV;GO:0016021|integral component of membrane;","GO:0004129|cytochrome-c oxidase activity;GO:0030234|enzyme regulator activity;","K02266","COX6A; cytochrome c oxidase subunit 6a"]
["ENSRNOG00000042360",20,1.66053321,2,0.128660876,12.90627934,3.690001251,{"v":4.95174e-06,"d":"4.95E-06"},{"v":6.93732e-06,"d":"6.94E-06"},"up","yes","Treml4","protein_coding","chr9:12721815-12743253:-","gi|564311158|ref|XP_006226779.1|",1081,{"v":3e-145,"d":"3.00E-145"},"PREDICTED: trem-like transcript 4 protein isoform X3 [Rattus norvegicus]","gi|255003765|ref|NM_001033922.2|",447,0,"Mus musculus triggering receptor expressed on myeloid cells-like 4 (Treml4), transcript variant 1, mRNA","Q3LRV9",338,{"v":4e-114,"d":"4.00E-114"},"Trem-like transcript 4 protein",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0002230|positive regulation of defense response to virus by host;GO:0002457|T cell antigen processing and presentation;GO:0006911|phagocytosis, engulfment;GO:0008104|protein localization;GO:0034157|positive regulation of toll-like receptor 7 signaling pathway;GO:0034165|positive regulation of toll-like receptor 9 signaling pathway;GO:0034181|positive regulation of toll-like receptor 13 signaling pathway;","GO:0005765|lysosomal membrane;GO:0005783|endoplasmic reticulum;GO:0010008|endosome membrane;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000065110",20,1.66053321,2,0.128660876,12.90627934,3.690001251,{"v":4.95174e-06,"d":"4.95E-06"},{"v":6.93732e-06,"d":"6.94E-06"},"up","yes","ENSRNOG00000065110","protein_coding","chr18:27483729-27499090:+","gi|166796835|gb|AAI59439.1|",640,{"v":3e-80,"d":"3.00E-80"},"Rps16 protein [Rattus norvegicus]","gi|298904831|emb|FQ228433.1|",423,0,"Rattus norvegicus TL0ADA8YI12 mRNA sequence","P62250",229,{"v":2E-73,"d":"2.00E-73"},"40S ribosomal protein S16","SPBC18H10.14",160,{"v":3e-47,"d":"3.00E-47"},"COG0103","pfam00380","Ribosomal_S9","Ribosomal protein S9/S16. This family includes small ribosomal subunit S9 from prokaryotes and S16 from eukaryotes.",".",".",".",".","."]
["ENSRNOG00000067464",26,2.158693174,5,0.321652191,6.711265257,2.746584779,{"v":5.01733e-06,"d":"5.02E-06"},{"v":7.02306e-06,"d":"7.02E-06"},"up","yes","Cysltr2","protein_coding","chr15:48189073-48304136:-","gi|19173778|ref|NP_596904.1|",1633,0,"cysteinyl leukotriene receptor 2 [Rattus norvegicus]","gi|672078647|ref|XM_008770842.1|",3512,0,"PREDICTED: Rattus norvegicus cysteinyl leukotriene receptor 2 (Cysltr2), transcript variant X1, mRNA","Q924T9",633,0,"Cysteinyl leukotriene receptor 2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.",".",".",".",".","."]
["ENSRNOG00000070745",26,2.158693174,5,0.321652191,6.711265257,2.746584779,{"v":5.01733e-06,"d":"5.02E-06"},{"v":7.02306e-06,"d":"7.02E-06"},"up","yes","Tnf","protein_coding","chr20:3622011-3624629:+","gi|972853972|tpe|CTQ86160.1|",1292,{"v":2e-172,"d":"2.00E-172"},"TPA: tumor necrosis factor ligand 1f [Mus musculus]","gi|672085853|ref|XM_008772775.1|",1687,0,"PREDICTED: Rattus norvegicus tumor necrosis factor (LOC103694380), mRNA","P16599",450,{"v":7e-155,"d":"7.00E-155"},"Tumor necrosis factor",".",".",".",".","pfam00229","TNF","TNF(tumor Necrosis Factor) family.",".",".",".",".","."]
["ENSRNOG00000015616",68,5.645812916,35,2.251565336,2.5075057,1.32625298,{"v":5.14639e-06,"d":"5.15E-06"},{"v":7.19426e-06,"d":"7.19E-06"},"up","yes","Rgs14","protein_coding","chr17:9249019-9263104:-","gi|16758600|ref|NP_446216.1|",2628,0,"regulator of G-protein signaling 14 [Rattus norvegicus]","gi|16758599|ref|NM_053764.1|",2831,0,"Rattus norvegicus regulator of G-protein signaling 14 (Rgs14), mRNA","O08773",1016,0,"Regulator of G-protein signaling 14",".",".",".",".","pfam00615","RGS","Regulator of G protein signaling domain. RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.","GO:0000278|mitotic cell cycle;GO:0006913|nucleocytoplasmic transport;GO:0006979|response to oxidative stress;GO:0007051|spindle organization;GO:0007059|chromosome segregation;GO:0007612|learning;GO:0007616|long-term memory;GO:0008277|regulation of G protein-coupled receptor signaling pathway;GO:0008542|visual learning;GO:0010070|zygote asymmetric cell division;GO:0031914|negative regulation of synaptic plasticity;GO:0035556|intracellular signal transduction;GO:0043407|negative regulation of MAP kinase activity;GO:0043547|positive regulation of GTPase activity;GO:0043620|regulation of DNA-templated transcription in response to stress;GO:0045744|negative regulation of G protein-coupled receptor signaling pathway;GO:0048008|platelet-derived growth factor receptor signaling pathway;GO:0050769|positive regulation of neurogenesis;GO:0050804|modulation of chemical synaptic transmission;GO:0051301|cell division;GO:0060291|long-term synaptic potentiation;GO:0070373|negative regulation of ERK1 and ERK2 cascade;","GO:0000922|spindle pole;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0005819|spindle;GO:0005874|microtubule;GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0016604|nuclear body;GO:0016605|PML body;GO:0030425|dendrite;GO:0043197|dendritic spine;GO:0098978|glutamatergic synapse;","GO:0001965|G-protein alpha-subunit binding;GO:0005092|GDP-dissociation inhibitor activity;GO:0005096|GTPase activator activity;GO:0005515|protein binding;GO:0008017|microtubule binding;GO:0019901|protein kinase binding;GO:0030159|receptor signaling complex scaffold activity;GO:0032794|GTPase activating protein binding;","K17706","RGS14; regulator of G-protein signaling 14"]
["ENSRNOG00000005776",74,6.143972879,40,2.573217527,2.387661678,1.255598427,{"v":5.17135E-6,"d":"5.17E-06"},{"v":7.22756e-06,"d":"7.23E-06"},"up","yes","Bcl11b","protein_coding","chr6:126834531-126928224:-","gi|471434853|ref|NP_001264216.1|",3280,0,"B-cell lymphoma/leukemia 11B isoform 1 [Rattus norvegicus]","gi|471434852|ref|NM_001277287.1|",5419,0,"Rattus norvegicus B-cell CLL/lymphoma 11B (Bcl11b), transcript variant 1, mRNA","Q99PV8",1256,0,"B-cell lymphoma/leukemia 11B",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0003334|keratinocyte development;GO:0003382|epithelial cell morphogenesis;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007409|axonogenesis;GO:0008285|negative regulation of cell proliferation;GO:0009791|post-embryonic development;GO:0010468|regulation of gene expression;GO:0010837|regulation of keratinocyte proliferation;GO:0019216|regulation of lipid metabolic process;GO:0021773|striatal medium spiny neuron differentiation;GO:0021902|commitment of neuronal cell to specific neuron type in forebrain;GO:0021953|central nervous system neuron differentiation;GO:0031077|post-embryonic camera-type eye development;GO:0033077|T cell differentiation in thymus;GO:0033153|T cell receptor V(D)J recombination;GO:0035701|hematopoietic stem cell migration;GO:0042475|odontogenesis of dentin-containing tooth;GO:0043066|negative regulation of apoptotic process;GO:0043368|positive T cell selection;GO:0043588|skin development;GO:0045664|regulation of neuron differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046632|alpha-beta T cell differentiation;GO:0048538|thymus development;GO:0071678|olfactory bulb axon guidance;GO:0097535|lymphoid lineage cell migration into thymus;","GO:0005634|nucleus;GO:0043005|neuron projection;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K22046","BCL11B; B-cell lymphoma/leukemia 11B"]
["ENSRNOG00000062621",24,1.992639853,4,0.257321753,7.743767604,2.953035657,{"v":5.39197e-06,"d":"5.39E-06"},{"v":7.51784e-06,"d":"7.52E-06"},"up","yes","Ly49i7","protein_coding","chr4:164853574-164867333:-","gi|57222326|ref|NP_001009500.1|",1377,0,"immunoreceptor Ly49i7 [Rattus norvegicus]","gi|672051553|ref|XM_008763440.1|",819,0,"PREDICTED: Rattus norvegicus killer cell lectin-like receptor 5-like (LOC100911272), mRNA","P20937",325,{"v":8e-110,"d":"8.00E-110"},"T-cell surface glycoprotein YE1/48",".",".",".",".","pfam08391","Ly49","Ly49-like protein, N-terminal region. The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).",".",".",".",".","."]
["ENSRNOG00000070418",22,1.826586532,3,0.192991315,9.464604849,3.242542274,{"v":5.40941e-06,"d":"5.41E-06"},{"v":7.53858e-06,"d":"7.54E-06"},"up","yes","ENSRNOG00000070418","lncRNA","chr17:67147484-67153664:-","gi|149063954|gb|EDM14224.1|",160,1e-09,"rCG23351 [Rattus norvegicus]","gi|672082524|ref|XR_596844.1|",1803,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102553434 (LOC102553434), ncRNA",".",".",".",".",".",".",".",".","pfam00684","DnaJ_CXXCXGXG","DnaJ central domain. The central cysteine-rich (CR) domain of DnaJ proteins contains four repeats of the motif CXXCXGXG where X is any amino acid. The isolated cysteine rich domain folds in zinc dependent fashion. Each set of two repeats binds one unit of zinc. Although this domain has been implicated in substrate binding, no evidence of specific interaction between the isolated DNAJ cysteine rich domain and various hydrophobic peptides has been found.",".",".",".",".","."]
["ENSRNOG00000016877",50,4.151333026,21,1.350939202,3.072923652,1.619611923,{"v":5.70248e-06,"d":"5.70E-06"},{"v":7.93347e-06,"d":"7.93E-06"},"up","yes","Shisa7","protein_coding","chr1:68994025-69012943:+","gi|564326273|ref|XP_006228352.1|",2043,0,"PREDICTED: protein shisa-7 isoform X1 [Rattus norvegicus]","gi|223633885|ref|NM_001145175.1|",6089,0,"Rattus norvegicus shisa family member 7 (Shisa7), mRNA","Q8C3Q5",736,0,"Protein shisa-7",".",".",".",".","pfam13908","Shisa","Wnt and FGF inhibitory regulator. Shisa is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface.","GO:0007214|gamma-aminobutyric acid signaling pathway;GO:0007613|memory;GO:0048172|regulation of short-term neuronal synaptic plasticity;GO:0097112|gamma-aminobutyric acid receptor clustering;GO:0098962|regulation of postsynaptic neurotransmitter receptor activity;GO:0106040|regulation of GABA-A receptor activity;GO:1900273|positive regulation of long-term synaptic potentiation;GO:1904717|regulation of AMPA glutamate receptor clustering;GO:2000311|regulation of AMPA receptor activity;","GO:0014069|postsynaptic density;GO:0032281|AMPA glutamate receptor complex;GO:0032591|dendritic spine membrane;GO:0045211|postsynaptic membrane;GO:0098978|glutamatergic synapse;GO:0098985|asymmetric, glutamatergic, excitatory synapse;GO:0099060|integral component of postsynaptic specialization membrane;","GO:0035255|ionotropic glutamate receptor binding;GO:0050811|GABA receptor binding;",".","."]
["ENSRNOG00000050059",50,4.151333026,21,1.350939202,3.072923652,1.619611923,{"v":5.70248e-06,"d":"5.70E-06"},{"v":7.93347e-06,"d":"7.93E-06"},"up","yes","ENSRNOG00000050059","protein_coding","chr12:18869048-18880075:+","gi|672072556|ref|XP_008767328.1|",1159,{"v":5e-155,"d":"5.00E-155"},"PREDICTED: paired immunoglobulin-like type 2 receptor alpha isoform X2 [Rattus norvegicus]","gi|672033485|ref|XM_008758270.1|",1017,0,"PREDICTED: Rattus norvegicus paired immunoglobin-like type 2 receptor alpha (Pilra), mRNA","Q2YFS3",335,{"v":3e-111,"d":"3.00E-111"},"Paired immunoglobulin-like type 2 receptor alpha",".",".",".",".","pfam14610","DUF4448","Protein of unknown function (DUF4448). This is a family of predicted membrane glycoproteins from fungi. However there appears, visually, to be some similarity with the family of GPI-anchored fungal proteins, pfam10342.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000054964",76,6.3100262,42,2.701878404,2.335421976,1.223683247,{"v":5.99817E-6,"d":"6.00E-06"},{"v":8.33034e-06,"d":"8.33E-06"},"up","yes","Aoah","protein_coding","chr17:43809638-44049148:-","gi|300794357|ref|NP_001178869.1|",3043,0,"acyloxyacyl hydrolase precursor [Rattus norvegicus]","gi|300794356|ref|NM_001191940.1|",1747,0,"Rattus norvegicus acyloxyacyl hydrolase (neutrophil) (Aoah), mRNA","O35298",1080,0,"Acyloxyacyl hydrolase",".",".",".",".","pfam00657","Lipase_GDSL","GDSL-like Lipase/Acylhydrolase.","GO:0006631|fatty acid metabolic process;GO:0008653|lipopolysaccharide metabolic process;GO:0009104|lipopolysaccharide catabolic process;GO:0050728|negative regulation of inflammatory response;","GO:0005576|extracellular region;GO:0043231|intracellular membrane-bounded organelle;","GO:0005509|calcium ion binding;GO:0050528|acyloxyacyl hydrolase activity;","K01065","AOAH; acyloxyacyl hydrolase [EC:3.1.1.77]"]
["ENSRNOG00000063332",37,3.071986439,12,0.771965258,3.97943613,1.992564021,{"v":6.75626e-06,"d":"6.76E-06"},{"v":9.32043e-06,"d":"9.32E-06"},"up","yes","ENSRNOG00000063332","protein_coding","chr8:123772025-123778284:+","gi|148671412|gb|EDL03359.1|",589,{"v":9e-74,"d":"9.00E-74"},"mCG1026173 [Mus musculus]","gi|49170117|gb|AC112361.5|",1595,0,"Rattus norvegicus 9 BAC CH230-61F12 (Children's Hospital Oakland Research Institute) complete sequence","P31789",170,{"v":7e-43,"d":"7.00E-43"},"Envelope glycoprotein",".",".",".",".","pfam07888","CALCOCO1","Calcium binding and coiled-coil domain (CALCOCO1) like. Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.",".",".",".",".","."]
["ENSRNOG00000016980",29,2.407773155,7,0.450313067,5.346887155,2.418699229,{"v":7.02535e-06,"d":"7.03E-06"},{"v":9.66663e-06,"d":"9.67E-06"},"up","yes","Qprt","protein_coding","chr1:181718190-181733486:-","gi|564330955|ref|XP_006230308.1|",1744,0,"PREDICTED: nicotinate-nucleotide pyrophosphorylase [carboxylating] isoform X1 [Rattus norvegicus]","gi|672038422|ref|XM_006230246.2|",1361,0,"PREDICTED: Rattus norvegicus quinolinate phosphoribosyltransferase (Qprt), transcript variant X1, mRNA","Q5I0M2",533,0,"Nicotinate-nucleotide pyrophosphorylase [carboxylating]","YFR047c",247,{"v":6e-76,"d":"6.00E-76"},"COG0157","pfam01729","QRPTase_C","Quinolinate phosphoribosyl transferase, C-terminal domain. Quinolinate phosphoribosyl transferase (QPRTase) or nicotinate-nucleotide pyrophosphorylase EC:2.4.2.19 is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to give rise to nicotinic acid mononucleotide (NaMN), pyrophosphate and carbon dioxide. The QA substrate is bound between the C-terminal domain of one subunit, and the N-terminal domain of the other. The C-terminal domain has a 7 beta-stranded TIM barrel-like fold.","GO:0009435|NAD biosynthetic process;GO:0034213|quinolinate catabolic process;GO:0046874|quinolinate metabolic process;","GO:0005737|cytoplasm;GO:1902494|catalytic complex;","GO:0004514|nicotinate-nucleotide diphosphorylase (carboxylating) activity;GO:0042802|identical protein binding;","K00767","nadC, QPRT; nicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:2.4.2.19]"]
["ENSRNOG00000063128",87,7.223319466,52,3.345182786,2.159319813,1.110576934,{"v":7.3836e-06,"d":"7.38E-06"},{"v":1.01356E-5,"d":"1.01E-05"},"up","yes","ENSRNOG00000063128","lncRNA","chr13:103495432-103497413:-",".",".",".",".","gi|74203083|dbj|AK145100.1|",1049,0,"Mus musculus mammary gland RCB-0526 Jyg-MC(A) cDNA, RIKEN full-length enriched library, clone:G830042M08 product:solute carrier family 30 (zinc transporter), member 1, full insert sequence",".",".",".",".",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.",".",".",".",".","."]
["ENSRNOG00000026310",44,3.653173063,17,1.093617449,3.34044877,1.740041934,{"v":7.52586E-6,"d":"7.53E-06"},{"v":1.02955E-5,"d":"1.03E-05"},"up","yes","Marchf1","protein_coding","chr16:23258799-24114277:-","gi|829901937|ref|XP_012591030.1|",2034,0,"PREDICTED: E3 ubiquitin-protein ligase MARCH1 isoform X1 [Microcebus murinus]","gi|755526033|ref|XM_006509754.2|",1608,0,"PREDICTED: Mus musculus membrane-associated ring finger (C3HC4) 1 (March1), transcript variant X1, mRNA","Q6NZQ8",449,{"v":2e-148,"d":"2.00E-148"},"E3 ubiquitin-protein ligase MARCH1","SPBC14F5.07",75.5,{"v":7e-13,"d":"7.00E-13"},"COG5183","pfam12906","RINGv","RING-variant domain.","GO:0000209|protein polyubiquitination;GO:0002495|antigen processing and presentation of peptide antigen via MHC class II;GO:0006955|immune response;","GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0005765|lysosomal membrane;GO:0005768|endosome;GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0031901|early endosome membrane;GO:0031902|late endosome membrane;GO:0032588|trans-Golgi network membrane;","GO:0004842|ubiquitin-protein transferase activity;GO:0008270|zinc ion binding;GO:0042287|MHC protein binding;GO:0061630|ubiquitin protein ligase activity;","K10656","MARCH1_8; E3 ubiquitin-protein ligase MARCH1/8 [EC:2.3.2.27]"]
["ENSRNOG00000064585",44,3.653173063,17,1.093617449,3.34044877,1.740041934,{"v":7.52586E-6,"d":"7.53E-06"},{"v":1.02955E-5,"d":"1.03E-05"},"up","yes","Dcdc2b","protein_coding","chr5:141951031-141967365:-","gi|564353124|ref|XP_006239049.1|",2018,0,"PREDICTED: LOW QUALITY PROTEIN: IQ domain-containing protein C [Rattus norvegicus]","gi|672054246|ref|XM_006238987.2|",1985,0,"PREDICTED: Rattus norvegicus IQ motif containing C (Iqcc), mRNA",".",".",".",".",".",".",".",".","pfam13270","DUF4061","Domain of unknown function (DUF4061). This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is approximately 90 amino acids in length. There is a conserved AFG sequence motif.",".",".",".",".","."]
["ENSRNOG00000005720",52,4.317386347,23,1.479600078,2.917941416,1.544950918,{"v":7.77954e-06,"d":"7.78E-06"},{"v":1.06107E-5,"d":"1.06E-05"},"up","yes","Spic","protein_coding","chr7:23069821-23077548:-","gi|564358895|ref|XP_006241285.1|",1292,{"v":2E-175,"d":"2.00E-175"},"PREDICTED: transcription factor Spi-C isoform X1 [Rattus norvegicus]","gi|672058223|ref|XM_006241223.2|",1302,0,"PREDICTED: Rattus norvegicus Spi-C transcription factor (Spi-1/PU.1 related) (Spic), transcript variant X1, mRNA","Q6P3D7",404,{"v":7E-139,"d":"7.00E-139"},"Transcription factor Spi-C",".",".",".",".","pfam00178","Ets","Ets-domain.","GO:0001824|blastocyst development;GO:0006357|regulation of transcription by RNA polymerase II;GO:0030154|cell differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;","K09440","SPIC; transcription factor Spi-C"]
["ENSRNOG00000002831",74,6.143972879,41,2.637547966,2.329426027,1.219974517,{"v":8.35717e-06,"d":"8.36E-06"},{"v":1.13502E-5,"d":"1.14E-05"},"up","yes","Wfikkn2","protein_coding","chr10:79186647-79191657:-","gi|27675188|ref|XP_220855.1|",2741,0,"PREDICTED: WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 isoform X2 [Rattus norvegicus]","gi|672069181|ref|XM_220855.8|",2541,0,"PREDICTED: Rattus norvegicus WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 (Wfikkn2), transcript variant X2, mRNA","Q7TQN3",1045,0,"WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2",".",".",".",".","pfam00014","Kunitz_BPTI","Kunitz/Bovine pancreatic trypsin inhibitor domain. Indicative of a protease inhibitor, usually a serine protease inhibitor. Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure. Certain family members are similar to the tick anticoagulant peptide (TAP). This is a highly selective inhibitor of factor Xa in the blood coagulation pathways. TAP molecules are highly dipolar, and are arranged to form a twisted two- stranded antiparallel beta-sheet followed by an alpha helix.","GO:0001501|skeletal system development;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0010951|negative regulation of endopeptidase activity;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0032091|negative regulation of protein binding;GO:0043392|negative regulation of DNA binding;GO:0055001|muscle cell development;GO:0060021|roof of mouth development;GO:2000272|negative regulation of signaling receptor activity;","GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0004867|serine-type endopeptidase inhibitor activity;GO:0008191|metalloendopeptidase inhibitor activity;GO:0048019|receptor antagonist activity;GO:0050431|transforming growth factor beta binding;","K23621","WFIKKN; WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein"]
["ENSRNOG00000007200",17,1.411453229,1,0.064330438,21.94067488,4.455535997,{"v":8.49541e-06,"d":"8.50E-06"},{"v":1.15257E-5,"d":"1.15E-05"},"up","yes","Ikzf3","protein_coding","chr10:83465745-83553591:-","gi|157820409|ref|NP_001100517.1|",2744,0,"zinc finger protein Aiolos [Rattus norvegicus]","gi|157820408|ref|NM_001107047.1|",2333,0,"Rattus norvegicus IKAROS family zinc finger 3 (Ikzf3), mRNA","O08900",1013,0,"Zinc finger protein Aiolos",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0009617|response to bacterium;GO:0030888|regulation of B cell proliferation;GO:0042981|regulation of apoptotic process;GO:0045577|regulation of B cell differentiation;GO:0045619|regulation of lymphocyte differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0042826|histone deacetylase binding;GO:0043565|sequence-specific DNA binding;GO:1990841|promoter-specific chromatin binding;","K09220","IKZF, ZNFN1A; IKAROS family zinc finger protein"]
["ENSRNOG00000018611",17,1.411453229,1,0.064330438,21.94067488,4.455535997,{"v":8.49541e-06,"d":"8.50E-06"},{"v":1.15257E-5,"d":"1.15E-05"},"up","yes","Tpsb2","protein_coding","chr10:14382013-14383569:+","gi|149052110|gb|EDM03927.1|",1384,0,"mast cell protease 6, isoform CRA_a [Rattus norvegicus]","gi|297374766|ref|NM_019180.2|",1070,0,"Rattus norvegicus tryptase beta 2 (Tpsb2), mRNA","P50343",534,0,"Tryptase beta-2","VC1649",118,{"v":2e-28,"d":"2.00E-28"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;","GO:0005615|extracellular space;","GO:0004252|serine-type endopeptidase activity;GO:0008201|heparin binding;GO:0008233|peptidase activity;","K01340","E3.4.21.59; tryptase [EC:3.4.21.59]"]
["ENSRNOG00000025930",17,1.411453229,1,0.064330438,21.94067488,4.455535997,{"v":8.49541e-06,"d":"8.50E-06"},{"v":1.15257E-5,"d":"1.15E-05"},"up","yes","Chst13","protein_coding","chr4:122824022-122838019:-","gi|300795042|ref|NP_001178903.1|",1755,0,"carbohydrate sulfotransferase 13 precursor [Rattus norvegicus]","gi|564347797|ref|XM_006236870.1|",1610,0,"PREDICTED: Rattus norvegicus carbohydrate (chondroitin 4) sulfotransferase 13 (Chst13), transcript variant X1, mRNA","Q8NET6",499,{"v":5e-172,"d":"5.00E-172"},"Carbohydrate sulfotransferase 13",".",".",".",".","pfam03567","Sulfotransfer_2","Sulfotransferase family. This family includes a variety of sulfotransferase enzymes. Chondroitin 6-sulfotransferase catalyses the transfer of sulfate to position 6 of the N-acetylgalactosamine residue of chondroitin. This family also includes Heparan sulfate 2-O-sulfotransferase (HS2ST) and Heparan sulfate 6-sulfotransferase (HS6ST). Heparan sulfate (HS) is a co-receptor for a number of growth factors, morphogens, and adhesion proteins. HS biosynthetic modifications may determine the strength and outcome of HS-ligand interactions. Mice that lack HS2ST undergo developmental failure only after midgestation,the most dramatic effect being the complete failure of kidney development. Heparan sulphate 6- O -sulfotransferase (HS6ST) catalyses the transfer of sulphate from adenosine 3'-phosphate, 5'-phosphosulphate to the 6th position of the N -sulphoglucosamine residue in heparan sulphate.","GO:0016051|carbohydrate biosynthetic process;GO:0030166|proteoglycan biosynthetic process;GO:0030206|chondroitin sulfate biosynthetic process;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0001537|N-acetylgalactosamine 4-O-sulfotransferase activity;GO:0008146|sulfotransferase activity;GO:0047756|chondroitin 4-sulfotransferase activity;","K07779","CHST13; chondroitin 4-sulfotransferase 13 [EC:2.8.2.5]"]
["ENSRNOG00000039678",38,3.1550131,13,0.836295696,3.77260473,1.915560951,{"v":8.81903e-06,"d":"8.82E-06"},{"v":1.19318E-5,"d":"1.19E-05"},"up","yes","ENSRNOG00000039678","protein_coding","chr11:41987207-41995209:+","gi|85701901|ref|NP_001028576.1|",463,{"v":1E-54,"d":"1.00E-54"},"uncharacterized protein LOC328695 [Mus musculus]","gi|672025955|ref|XR_601951.1|",112,{"v":1e-49,"d":"1.00E-49"},"PREDICTED: Rattus norvegicus uncharacterized LOC102553417 (LOC102553417), transcript variant X5, ncRNA",".",".",".",".",".",".",".",".","pfam00210","Ferritin","Ferritin-like domain. This family contains ferritins and other ferritin-like proteins such as members of the DPS family and bacterioferritins.","GO:0006826|iron ion transport;",".",".",".","."]
["ENSRNOG00000031785",16,1.328426568,0,0.032165219,41.30009389,5.368073156,{"v":8.87675e-06,"d":"8.88E-06"},{"v":1.20023E-5,"d":"1.20E-05"},"up","yes","Krt76","protein_coding","chr7:133016992-133025496:-","gi|57012372|ref|NP_001008805.1|",1996,0,"keratin, type II cytoskeletal 2 oral [Rattus norvegicus]","gi|57012371|ref|NM_001008805.1|",1746,0,"Rattus norvegicus keratin 76, type II (Krt76), mRNA","Q3UV17",674,0,"Keratin, type II cytoskeletal 2 oral",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0007010|cytoskeleton organization;GO:0008544|epidermis development;GO:0043473|pigmentation;GO:0045103|intermediate filament-based process;GO:0048733|sebaceous gland development;","GO:0005882|intermediate filament;GO:0045095|keratin filament;","GO:0005200|structural constituent of cytoskeleton;","K07605","KRT2; type II keratin, basic"]
["ENSRNOG00000046076",16,1.328426568,0,0.032165219,41.30009389,5.368073156,{"v":8.87675e-06,"d":"8.88E-06"},{"v":1.20023E-5,"d":"1.20E-05"},"up","yes","Tspan10","protein_coding","chr10:105715961-105719813:+","gi|672025580|ref|XP_006221038.2|",1324,0,"PREDICTED: tetraspanin-10 [Rattus norvegicus]","gi|672025579|ref|XM_006220976.2|",991,0,"PREDICTED: Rattus norvegicus tetraspanin 10 (Tspan10), mRNA","Q8VCF5",428,{"v":3E-148,"d":"3.00E-148"},"Tetraspanin-10",".",".",".",".","pfam00335","Tetraspannin","Tetraspanin family.","GO:0051604|protein maturation;GO:0072594|establishment of protein localization to organelle;","GO:0005887|integral component of plasma membrane;","GO:0019899|enzyme binding;","K17351","TSPAN10; tetraspanin-10"]
["ENSRNOG00000064957",35,2.905933118,11,0.70763482,4.106543426,2.037924554,{"v":8.89254e-06,"d":"8.89E-06"},{"v":1.20211e-05,"d":"1.20E-05"},"up","yes","Ly49si3","protein_coding","chr4:163480531-163503985:-","gi|57222324|ref|NP_001009498.1|",1227,{"v":8E-167,"d":"8.00E-167"},"immunoreceptor Ly49si2 [Rattus norvegicus]","gi|672051477|ref|XM_008763413.1|",906,0,"PREDICTED: Rattus norvegicus immunoreceptor Ly49si3 (Ly49si3), transcript variant X5, mRNA","P20937",268,{"v":2e-86,"d":"2.00E-86"},"T-cell surface glycoprotein YE1/48",".",".",".",".","pfam08391","Ly49","Ly49-like protein, N-terminal region. The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).",".",".",".",".","."]
["ENSRNOG00000009505",19,1.57750655,2,0.128660876,12.26096537,3.61600067,{"v":9.95188e-06,"d":"9.95E-06"},{"v":1.3374e-05,"d":"1.34E-05"},"up","yes","Cd164l2","protein_coding","chr5:145423892-145427720:+","gi|564353138|ref|XP_006239054.1|",688,{"v":6e-88,"d":"6.00E-88"},"PREDICTED: CD164 sialomucin-like 2 protein isoform X1 [Rattus norvegicus]","gi|404247436|ref|NM_001271259.1|",854,0,"Rattus norvegicus CD164 molecule like 2 (Cd164l2), mRNA","Q9D6W7",250,{"v":1e-81,"d":"1.00E-81"},"CD164 sialomucin-like 2 protein",".",".",".",".","pfam05283","MGC-24","Multi-glycosylated core protein 24 (MGC-24). This family consists of several MGC-24 (or Cd164 antigen) proteins from eukaryotic organisms. MGC-24/CD164 is a sialomucin expressed in many normal and cancerous tissues. In humans, soluble and transmembrane forms of MGC-24 are produced by alternative splicing.",".","GO:0016021|integral component of membrane;GO:0031410|cytoplasmic vesicle;",".",".","."]
["ENSRNOG00000066100",42,3.487119742,16,1.029287011,3.387898327,1.760390579,{"v":1.02956E-5,"d":"1.03E-05"},{"v":1.38182e-05,"d":"1.38E-05"},"up","yes","ENSRNOG00000066100","TR_C_gene","chr17:45678485-45678628:-","gi|913547|gb|AAB32520.1|",148,{"v":3E-10,"d":"3.00E-10"},"T-cell receptor gamma chain [Rattus sp.]","gi|558686|emb|Z27087.1|",144,{"v":3E-68,"d":"3.00E-68"},"R.norvegicus (F344/Crj)rearranged mRNA for T-cell receptor gamma chain (1483bp)","P01853",48.1,1e-07,"T-cell receptor gamma chain C region C10.5",".",".",".",".","pfam02066","Metallothio_11","Metallothionein family 11.",".",".",".",".","."]
["ENSRNOG00000018978",21,1.743559871,3,0.192991315,9.034395538,3.175428078,{"v":1.06957E-5,"d":"1.07E-05"},{"v":1.43104e-05,"d":"1.43E-05"},"up","yes","Scart1","protein_coding","chr1:195020750-195031807:+","gi|149061488|gb|EDM11911.1|",5011,0,"rCG47791, isoform CRA_b [Rattus norvegicus]","gi|157821230|ref|NM_001106312.1|",3228,0,"Rattus norvegicus CD163 molecule-like 1 (Cd163l1), mRNA","Q4G0T1",1067,0,"Scavenger receptor cysteine-rich domain-containing protein SCART1",".",".",".",".","pfam00530","SRCR","Scavenger receptor cysteine-rich domain. These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.","GO:0006897|endocytosis;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005903|brush border;GO:0009897|external side of plasma membrane;","GO:0005044|scavenger receptor activity;",".","."]
["ENSRNOG00000031202",21,1.743559871,3,0.192991315,9.034395538,3.175428078,{"v":1.06957E-5,"d":"1.07E-05"},{"v":1.43104e-05,"d":"1.43E-05"},"up","yes","Trim30c","protein_coding","chr1:158765969-158787183:-","gi|564298115|ref|XP_006223500.1|",2667,0,"PREDICTED: tripartite motif-containing protein 30A-like [Rattus norvegicus]","gi|672014100|ref|XM_006223438.2|",1853,0,"PREDICTED: Rattus norvegicus tripartite motif-containing protein 30A-like (LOC102554102), transcript variant X1, mRNA","P15533",682,0,"Tripartite motif-containing protein 30A",".",".",".",".","pfam00097","zf-C3HC4","Zinc finger, C3HC4 type (RING finger). The C3HC4 type zinc-finger (RING finger) is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C where X is any amino acid. Many proteins containing a RING finger play a key role in the ubiquitination pathway.",".",".","GO:0008270|zinc ion binding;",".","."]
["ENSRNOG00000043323",21,1.743559871,3,0.192991315,9.034395538,3.175428078,{"v":1.06957E-5,"d":"1.07E-05"},{"v":1.43104e-05,"d":"1.43E-05"},"up","yes","ENSRNOG00000043323","protein_coding","chr3:7021973-7031619:-","gi|564339567|ref|XP_006233676.1|",968,{"v":2e-129,"d":"2.00E-129"},"PREDICTED: interleukin-36 beta isoform X1 [Rattus norvegicus]","gi|672044682|ref|XM_006233617.2|",943,0,"PREDICTED: Rattus norvegicus interleukin 36, beta (Il36b), transcript variant X3, mRNA","Q9D6Z6",272,{"v":1E-89,"d":"1.00E-89"},"Interleukin-36 beta",".",".",".",".","pfam00340","IL1","Interleukin-1 / 18. This family includes interleukin-1 and interleukin-18.","GO:0001819|positive regulation of cytokine production;GO:0002437|inflammatory response to antigenic stimulus;GO:0006954|inflammatory response;GO:0010628|positive regulation of gene expression;GO:0019221|cytokine-mediated signaling pathway;GO:0032755|positive regulation of interleukin-6 production;GO:0045582|positive regulation of T cell differentiation;GO:0071222|cellular response to lipopolysaccharide;","GO:0005615|extracellular space;","GO:0005125|cytokine activity;GO:0005149|interleukin-1 receptor binding;","K05486","IL36B, IL1F8; interleukin 36 beta"]
["ENSRNOG00000003722",78,6.476079521,45,2.894869718,2.237088419,1.161622279,{"v":1.08188e-05,"d":"1.08E-05"},{"v":1.4469E-5,"d":"1.45E-05"},"up","yes","Dusp27","protein_coding","chr13:78349365-78378458:-","gi|300794139|ref|NP_001178858.1|",4689,0,"inactive dual specificity phosphatase 27 [Rattus norvegicus]","gi|672074526|ref|XM_006250187.2|",4036,0,"PREDICTED: Rattus norvegicus dual specificity phosphatase 27 (putative) (Dusp27), transcript variant X2, mRNA","Q148W8",1659,0,"Inactive dual specificity phosphatase 27","SPBC17A3.06",70.5,{"v":6e-12,"d":"6.00E-12"},"COG2453","pfam00782","DSPc","Dual specificity phosphatase, catalytic domain. Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a \"recognition\" region.","GO:0006470|protein dephosphorylation;GO:0043409|negative regulation of MAPK cascade;","GO:0005737|cytoplasm;","GO:0008138|protein tyrosine/serine/threonine phosphatase activity;GO:0033549|MAP kinase phosphatase activity;","K14165","K14165; atypical dual specificity phosphatase [EC:3.1.3.16 3.1.3.48]"]
["ENSRNOG00000051294",50,4.151333026,22,1.41526964,2.933245304,1.552497727,{"v":1.08254E-5,"d":"1.08E-05"},{"v":1.44718e-05,"d":"1.45E-05"},"up","yes","AABR07034923.1","protein_coding","chr12:46534-56425:-","gi|293340970|ref|XP_002724811.1|",1394,0,"PREDICTED: ZAR1-like protein isoform X1 [Rattus norvegicus]","gi|293340969|ref|XM_002724765.1|",879,0,"PREDICTED: Rattus norvegicus zygote arrest 1-like (Zar1l), transcript variant X1, mRNA","A6NP61",300,{"v":8e-99,"d":"8.00E-99"},"ZAR1-like protein",".",".",".",".","pfam13695","zf-3CxxC","Zinc-binding domain. This is a family with several pairs of CxxC motifs possibly representing a multiple zinc-binding region. Only one pair of cysteines is associated with a highly conserved histidine residue.",".",".",".",".","."]
["ENSRNOG00000067449",46,3.819226384,19,1.222278326,3.124678156,1.643707599,{"v":1.0915E-5,"d":"1.09E-05"},{"v":1.45825E-5,"d":"1.46E-05"},"up","yes","ENSRNOG00000067449","lncRNA","chr10:104292395-104293585:-",".",".",".",".","gi|26342293|dbj|AK051905.1|",861,0,"Mus musculus 12 days embryo eyeball cDNA, RIKEN full-length enriched library, clone:D230017K24 product:chromobox homolog 8 (Drosophila Pc class), full insert sequence",".",".",".",".",".",".",".",".","pfam15301","SLAIN","SLAIN motif-containing family. The SLAIN motif containing family is named after the presence of a SLAIN motif in SLAIN1. They are a family of microtubule plus-end tracking proteins.",".",".",".",".","."]
["ENSRNOG00000009892",87,7.223319466,53,3.409513224,2.118577929,1.083096197,{"v":1.12172E-5,"d":"1.12E-05"},{"v":1.49611E-5,"d":"1.50E-05"},"up","yes","Adamts15","protein_coding","chr8:29307865-29331249:-","gi|157819065|ref|NP_001100280.1|",4986,0,"A disintegrin and metalloproteinase with thrombospondin motifs 15 precursor [Rattus norvegicus]","gi|157819064|ref|NM_001106810.1|",6064,0,"Rattus norvegicus ADAM metallopeptidase with thrombospondin type 1 motif, 15 (Adamts15), mRNA","P59384",1909,0,"A disintegrin and metalloproteinase with thrombospondin motifs 15",".",".",".",".","pfam05986","ADAM_spacer1","ADAM-TS Spacer 1. This family represents the Spacer-1 region from the ADAM-TS family of metalloproteinases.","GO:0006508|proteolysis;GO:0007229|integrin-mediated signaling pathway;GO:0007520|myoblast fusion;GO:0022617|extracellular matrix disassembly;GO:0030198|extracellular matrix organization;","GO:0005615|extracellular space;GO:0009986|cell surface;GO:0031012|extracellular matrix;GO:0062023|collagen-containing extracellular matrix;","GO:0004175|endopeptidase activity;GO:0004222|metalloendopeptidase activity;GO:0008201|heparin binding;GO:0008270|zinc ion binding;GO:0050840|extracellular matrix binding;","K08629","ADAMTS15; a disintegrin and metalloproteinase with thrombospondin motifs 15 [EC:3.4.24.-]"]
["ENSRNOG00000016716",36,2.988959779,12,0.771965258,3.871883802,1.953035657,{"v":1.17695E-5,"d":"1.18E-05"},{"v":1.56489e-05,"d":"1.56E-05"},"up","yes","Armc3","protein_coding","chr17:81832518-81917531:+","gi|559098430|ref|NP_001273949.1|",3805,0,"armadillo repeat-containing protein 3 [Rattus norvegicus]","gi|559098429|ref|NM_001287020.1|",2755,0,"Rattus norvegicus armadillo repeat containing 3 (Armc3), mRNA","A2AU72",1357,0,"Armadillo repeat-containing protein 3",".",".",".",".","pfam14381","EDR1","Ethylene-responsive protein kinase Le-CTR1. EDR1 regulates disease resistance and ethylene-induced senescence, and is also involved in stress response signalling and cell death regulation.",".",".",".","K24124","ARMC3; armadillo repeat-containing protein 3"]
["ENSRNOG00000060879",51,4.234359687,23,1.479600078,2.861827158,1.516936542,{"v":1.24915e-05,"d":"1.25E-05"},{"v":1.65469e-05,"d":"1.65E-05"},"up","yes","ENSRNOG00000060879","protein_coding","chr7:20015102-20057975:-","gi|537241732|gb|ERE87282.1|",349,{"v":1e-36,"d":"1.00E-36"},"putative overexpressed in colon carcinoma 1 protein like protein [Cricetulus griseus]","gi|672058163|ref|XM_008765212.1|",1130,0,"PREDICTED: Rattus norvegicus uncharacterized LOC100910996 (LOC100910996), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam15506","OCC1","OCC1 family. The human member of this family, overexpressed in colon carcinoma 1 protein has been shown to be overexpressed in several colon carcinomas.",".",".",".",".","."]
["ENSRNOG00000016204",81,6.725159503,48,3.087861033,2.177934639,1.122960658,{"v":1.27795E-5,"d":"1.28E-05"},{"v":1.68864e-05,"d":"1.69E-05"},"up","yes","Lrrc24","protein_coding","chr7:108437296-108444438:-","gi|209571482|ref|NP_001129368.1|",2028,0,"leucine-rich repeat-containing protein 24 precursor [Rattus norvegicus]","gi|209571481|ref|NM_001135896.1|",1850,0,"Rattus norvegicus leucine rich repeat containing 24 (Lrrc24), mRNA","Q8BHA1",732,0,"Leucine-rich repeat-containing protein 24",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0051965|positive regulation of synapse assembly;","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000035591",28,2.324746495,7,0.450313067,5.162511736,2.368073156,{"v":1.29792e-05,"d":"1.30E-05"},{"v":1.71326e-05,"d":"1.71E-05"},"up","yes","Mir126a","miRNA","chr3:9415063-9415180:-",".",".",".",".","gi|312147318|ref|NR_037353.1|",118,{"v":6e-54,"d":"6.00E-54"},"Rattus norvegicus microRNA 3567 (Mir3567), microRNA",".",".",".",".",".",".",".",".","pfam10463","Peptidase_U49","Peptidase U49. This family contains Lit peptidase from Escherichia coli. Lit protease functions in bacterial cell death in response to infection by bacteriophage T4. Following binding of Gol peptide to domains II and III of elongation factor Tu, the Lit peptidase cleaves domain I of the elongation factor. This prevents binding of guanine nucleotides, shuts down translation and leads to cell death.","GO:0009617|response to bacterium;GO:0060218|hematopoietic stem cell differentiation;GO:0060291|long-term synaptic potentiation;GO:0070482|response to oxygen levels;GO:0071391|cellular response to estrogen stimulus;","GO:0045202|synapse;",".",".","."]
["ENSRNOG00000003716",92,7.638452768,58,3.731165415,2.04720293,1.033654117,{"v":1.37615E-5,"d":"1.38E-05"},{"v":1.80943e-05,"d":"1.81E-05"},"up","yes","Batf3","protein_coding","chr13:102689657-102701139:+","gi|11177912|ref|NP_068637.1|",437,{"v":6E-52,"d":"6.00E-52"},"basic leucine zipper transcriptional factor ATF-like 3 [Rattus norvegicus]","gi|672075197|ref|XM_008769873.1|",343,{"v":3e-178,"d":"3.00E-178"},"PREDICTED: Rattus norvegicus basic leucine zipper transcription factor, ATF-like 3 (Batf3), transcript variant X1, mRNA","P97876",172,{"v":2e-53,"d":"2.00E-53"},"Basic leucine zipper transcriptional factor ATF-like 3",".",".",".",".","pfam07716","bZIP_2","Basic region leucine zipper.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;GO:0009615|response to virus;GO:0043011|myeloid dendritic cell differentiation;GO:0097028|dendritic cell differentiation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005829|cytosol;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0044877|protein-containing complex binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09034","BATF; ATF-like basic leucine zipper transcriptional factor"]
["ENSRNOG00000067229",31,2.573826476,9,0.578973944,4.445496217,2.152344465,{"v":1.49802e-05,"d":"1.50E-05"},{"v":1.9624E-5,"d":"1.96E-05"},"up","yes","ENSRNOG00000067229","protein_coding","chr4:83921470-83930590:-","gi|5802821|gb|AAD51797.1|AF164614_1",2271,0,"Gag-Pro-Pol protein [Homo sapiens]","gi|378744249|gb|AC246509.4|",5333,0,"Rattus norvegicus Y Chr BAC RNECO-104M15 (Amplicon Express Rat SHR-Akr (EcoR1 Digest) BAC library) complete sequence","Q9UQG0",787,0,"Endogenous retrovirus group K member 11 Pol protein","YIL082w-a_2",66.6,1e-09,"COG2801","pfam00078","RVT_1","Reverse transcriptase (RNA-dependent DNA polymerase). A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs, hepadnaviruses, and caulimoviruses.",".",".",".",".","."]
["ENSRNOG00000004150",37,3.071986439,13,0.836295696,3.673325658,1.877086804,{"v":1.51794e-05,"d":"1.52E-05"},{"v":1.98728e-05,"d":"1.99E-05"},"up","yes","Slc9a7","protein_coding","chrX:2214441-2388012:+","gi|564398462|ref|XP_006256698.1|",3144,0,"PREDICTED: sodium/hydrogen exchanger 7 isoform X1 [Rattus norvegicus]","gi|672086857|ref|XM_006256636.2|",2554,0,"PREDICTED: Rattus norvegicus solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 (Slc9a7), transcript variant X1, mRNA","Q8BLV3",1192,0,"Sodium/hydrogen exchanger 7","YDR456w",243,{"v":2e-68,"d":"2.00E-68"},"COG0025","pfam00999","Na_H_Exchanger","Sodium/hydrogen exchanger family. Na/H antiporters are key transporters in maintaining the pH of actively metabolizing cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.","GO:0006885|regulation of pH;GO:0051453|regulation of intracellular pH;GO:0071805|potassium ion transmembrane transport;GO:0098656|anion transmembrane transport;GO:0098719|sodium ion import across plasma membrane;GO:1902600|proton transmembrane transport;GO:1905526|regulation of Golgi lumen acidification;","GO:0005802|trans-Golgi network;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0055037|recycling endosome;GO:0055038|recycling endosome membrane;","GO:0015385|sodium:proton antiporter activity;GO:0015386|potassium:proton antiporter activity;",".","."]
["ENSRNOG00000036837",63,5.230679613,33,2.12290446,2.463926056,1.30095896,{"v":1.53816e-05,"d":"1.54E-05"},{"v":2.01334e-05,"d":"2.01E-05"},"up","yes","Nfe2","protein_coding","chr7:134382761-134390108:-","gi|149031876|gb|EDL86788.1|",1813,0,"rCG50844 [Rattus norvegicus]","gi|672060219|ref|XM_006242432.2|",1687,0,"PREDICTED: Rattus norvegicus nuclear factor, erythroid 2 (Nfe2), transcript variant X2, mRNA","Q6AYT2",657,0,"Transcription factor NF-E2 45 kDa subunit",".",".",".",".","pfam03131","bZIP_Maf","bZIP Maf transcription factor. Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerization and DNA binding property. Thus, this family is probably related to pfam00170. This family also includes the DNA_binding domain of Skn-1, this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0007267|cell-cell signaling;GO:0008285|negative regulation of cell proliferation;GO:0010467|gene expression;GO:0010468|regulation of gene expression;GO:0030502|negative regulation of bone mineralization;GO:0034242|negative regulation of syncytium formation by plasma membrane fusion;GO:0060716|labyrinthine layer blood vessel development;GO:2000758|positive regulation of peptidyl-lysine acetylation;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0016605|PML body;GO:0032993|protein-DNA complex;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987|proximal promoter sequence-specific DNA binding;GO:0003677|DNA binding;GO:0042802|identical protein binding;GO:0047485|protein N-terminus binding;GO:0050699|WW domain binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09039","NFE2; nuclear factor erythroid 2"]
["ENSRNOG00000042547",15,1.245399908,0,0.032165219,38.71883802,5.274963752,{"v":1.73962e-05,"d":"1.74E-05"},{"v":2.26497e-05,"d":"2.26E-05"},"up","yes","AABR07001902.1","protein_coding","chr1:61493819-61494744:+","gi|47059006|ref|NP_997675.1|",879,{"v":2E-118,"d":"2.00E-118"},"60S ribosomal protein L18a [Rattus norvegicus]","gi|970259769|ref|NM_212510.2|",463,0,"Rattus norvegicus ribosomal protein L18A (Rpl18a), mRNA","P62718",343,{"v":8e-120,"d":"8.00E-120"},"60S ribosomal protein L18a","YMR242c",187,{"v":6e-59,"d":"6.00E-59"},"COG2157","pfam01775","Ribosomal_L18ae","Ribosomal L18ae/LX protein domain. This family includes eukaryotic L18ae as well as archaebacterial specific LX. Ribosomal protein L18ae forms part of the 60S ribosomal subunit.","GO:0006412|translation;",".","GO:0003735|structural constituent of ribosome;",".","."]
["ENSRNOG00000024210",88,7.306346126,55,3.5381741,2.065004694,1.046145061,{"v":1.75367e-05,"d":"1.75E-05"},{"v":2.28188e-05,"d":"2.28E-05"},"up","yes","Nlrc3","protein_coding","chr10:11551356-11584398:+","gi|672024531|ref|XP_006220627.2|",5301,0,"PREDICTED: protein NLRC3 [Rattus norvegicus]","gi|672024530|ref|XM_006220565.2|",4444,0,"PREDICTED: Rattus norvegicus NLR family, CARD domain containing 3 (Nlrc3), mRNA","Q5DU56",1811,0,"Protein NLRC3",".",".",".",".","pfam05729","NACHT","NACHT domain. This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.","GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0014067|negative regulation of phosphatidylinositol 3-kinase signaling;GO:0031396|regulation of protein ubiquitination;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0032496|response to lipopolysaccharide;GO:0032687|negative regulation of interferon-alpha production;GO:0032688|negative regulation of interferon-beta production;GO:0032691|negative regulation of interleukin-1 beta production;GO:0032695|negative regulation of interleukin-12 production;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0035556|intracellular signal transduction;GO:0042110|T cell activation;GO:0043124|negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045824|negative regulation of innate immune response;GO:0048147|negative regulation of fibroblast proliferation;GO:0050680|negative regulation of epithelial cell proliferation;GO:0050728|negative regulation of inflammatory response;GO:1900016|negative regulation of cytokine production involved in inflammatory response;GO:1900226|negative regulation of NLRP3 inflammasome complex assembly;GO:1901223|negative regulation of NIK/NF-kappaB signaling;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0034451|centriolar satellite;GO:0043231|intracellular membrane-bounded organelle;GO:0048471|perinuclear region of cytoplasm;","GO:0003674|molecular_function;GO:0036312|phosphatidylinositol 3-kinase regulatory subunit binding;","K22614","NLRC3, NOD3; NLR family CARD domain-containing protein 3"]
["ENSRNOG00000012215",38,3.1550131,14,0.900626135,3.503132964,1.808645748,{"v":1.91406e-05,"d":"1.91E-05"},{"v":2.47748e-05,"d":"2.48E-05"},"up","yes","Baiap2l2","protein_coding","chr7:110824375-110850702:-","gi|403420586|ref|NP_001258149.1|",2275,0,"brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 [Rattus norvegicus]","gi|403420585|ref|NM_001271220.1|",2079,0,"Rattus norvegicus BAI1-associated protein 2-like 2 (Baiap2l2), mRNA","Q80Y61",868,0,"Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2",".",".",".",".","pfam08397","IMD","IRSp53/MIM homology domain. The N-terminal predicted helical stretch of the insulin receptor tyrosine kinase substrate p53 (IRSp53) is an evolutionary conserved F-actin bundling domain involved in filopodium formation. The domain has been named IMD after the IRSp53 and missing in metastasis (MIM) proteins in which it occurs. Filopodium-inducing IMD activity is regulated by Cdc42 and Rac1 and is SH3-independent.","GO:0007009|plasma membrane organization;GO:0030838|positive regulation of actin filament polymerization;GO:0051017|actin filament bundle assembly;GO:0051764|actin crosslink formation;GO:0061024|membrane organization;GO:2000251|positive regulation of actin cytoskeleton reorganization;","GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0012506|vesicle membrane;GO:0044291|cell-cell contact zone;GO:0071439|clathrin complex;","GO:0005543|phospholipid binding;GO:0042802|identical protein binding;","K23645","BAIAP2L2; BAI1-associated protein 2-like protein 2"]
["ENSRNOG00000010121",81,6.725159503,49,3.152191471,2.133486993,1.093213315,{"v":1.95294E-5,"d":"1.95E-05"},{"v":2.52524e-05,"d":"2.53E-05"},"up","yes","Lef1","protein_coding","chr2:219666592-219779794:+","gi|564338789|ref|XP_006233365.1|",1915,0,"PREDICTED: lymphoid enhancer-binding factor 1 isoform X1 [Rattus norvegicus]","gi|672044166|ref|XM_006233303.2|",3234,0,"PREDICTED: Rattus norvegicus lymphoid enhancer binding factor 1 (Lef1), transcript variant X4, mRNA","Q9QXN1",737,0,"Lymphoid enhancer-binding factor 1",".",".",".",".","pfam08347","CTNNB1_binding","N-terminal CTNNB1 binding. This region tends to appear at the N-terminus of proteins also containing DNA-binding HMG (high mobility group) boxes (pfam00505) and appears to bind the armadillo repeat of CTNNB1 (beta-catenin), forming a stable complex. Signaling by Wnt through TCF/LCF is involved in developmental patterning, induction of neural tissues, cell fate decisions and stem cell differentiation. Isoforms of HMG T-cell factors lacking the N-terminal CTNNB1-binding domain cannot fulfill their role as transcriptional activators in T-cell differentiation.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001569|branching involved in blood vessel morphogenesis;GO:0001649|osteoblast differentiation;GO:0001756|somitogenesis;GO:0001822|kidney development;GO:0001837|epithelial to mesenchymal transition;GO:0001944|vasculature development;GO:0002040|sprouting angiogenesis;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007155|cell adhesion;GO:0008284|positive regulation of cell proliferation;GO:0010226|response to lithium ion;GO:0010628|positive regulation of gene expression;GO:0010718|positive regulation of epithelial to mesenchymal transition;GO:0014070|response to organic cyclic compound;GO:0021542|dentate gyrus development;GO:0021766|hippocampus development;GO:0021861|forebrain radial glial cell differentiation;GO:0021873|forebrain neuroblast division;GO:0021943|formation of radial glial scaffolds;GO:0022407|regulation of cell-cell adhesion;GO:0022408|negative regulation of cell-cell adhesion;GO:0022409|positive regulation of cell-cell adhesion;GO:0030111|regulation of Wnt signaling pathway;GO:0030177|positive regulation of Wnt signaling pathway;GO:0030223|neutrophil differentiation;GO:0030326|embryonic limb morphogenesis;GO:0030335|positive regulation of cell migration;GO:0030509|BMP signaling pathway;GO:0030854|positive regulation of granulocyte differentiation;GO:0030879|mammary gland development;GO:0031100|animal organ regeneration;GO:0032696|negative regulation of interleukin-13 production;GO:0032713|negative regulation of interleukin-4 production;GO:0032714|negative regulation of interleukin-5 production;GO:0033153|T cell receptor V(D)J recombination;GO:0042100|B cell proliferation;GO:0042475|odontogenesis of dentin-containing tooth;GO:0043066|negative regulation of apoptotic process;GO:0043392|negative regulation of DNA binding;GO:0043586|tongue development;GO:0043588|skin development;GO:0043923|positive regulation by host of viral transcription;GO:0043966|histone H3 acetylation;GO:0043967|histone H4 acetylation;GO:0045063|T-helper 1 cell differentiation;GO:0045588|positive regulation of gamma-delta T cell differentiation;GO:0045843|negative regulation of striated muscle tissue development;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046632|alpha-beta T cell differentiation;GO:0048341|paraxial mesoderm formation;GO:0048468|cell development;GO:0050909|sensory perception of taste;GO:0060033|anatomical structure regression;GO:0060070|canonical Wnt signaling pathway;GO:0060325|face morphogenesis;GO:0060326|cell chemotaxis;GO:0060561|apoptotic process involved in morphogenesis;GO:0060710|chorio-allantoic fusion;GO:0061153|trachea gland development;GO:0062009|secondary palate development;GO:0071345|cellular response to cytokine stimulus;GO:0071353|cellular response to interleukin-4;GO:0071864|positive regulation of cell proliferation in bone marrow;GO:0071866|negative regulation of apoptotic process in bone marrow;GO:0071895|odontoblast differentiation;GO:0090068|positive regulation of cell cycle process;GO:0097043|histone H3-K56 acetylation;GO:1902262|apoptotic process involved in blood vessel morphogenesis;GO:1902732|positive regulation of chondrocyte proliferation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005737|cytoplasm;GO:0032993|protein-DNA complex;GO:1990907|beta-catenin-TCF complex;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987|proximal promoter sequence-specific DNA binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003700|DNA-binding transcription factor activity;GO:0005515|protein binding;GO:0008013|beta-catenin binding;GO:0008301|DNA binding, bending;GO:0030331|estrogen receptor binding;GO:0042393|histone binding;GO:0042826|histone deacetylase binding;GO:0043565|sequence-specific DNA binding;GO:0045295|gamma-catenin binding;GO:0070016|armadillo repeat domain binding;GO:0070742|C2H2 zinc finger domain binding;GO:1990837|sequence-specific double-stranded DNA binding;","K04492","LEF1; lymphoid enhancer-binding factor 1"]
["ENSRNOG00000008422",18,1.494479889,2,0.128660876,11.61565141,3.537998158,{"v":2.00019e-05,"d":"2.00E-05"},{"v":2.58111e-05,"d":"2.58E-05"},"up","yes","Lpo","protein_coding","chr10:72606944-72626535:-","gi|157786856|ref|NP_001099299.1|",3652,0,"lactoperoxidase precursor [Rattus norvegicus]","gi|157786855|ref|NM_001105829.1|",2930,0,"Rattus norvegicus lactoperoxidase (Lpo), mRNA","Q8R481",1108,0,"Lactoperoxidase",".",".",".",".","pfam03098","An_peroxidase","Animal haem peroxidase.","GO:0001580|detection of chemical stimulus involved in sensory perception of bitter taste;GO:0006979|response to oxidative stress;GO:0018969|thiocyanate metabolic process;GO:0042742|defense response to bacterium;GO:0098869|cellular oxidant detoxification;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0016323|basolateral plasma membrane;","GO:0004601|peroxidase activity;GO:0020037|heme binding;GO:0036393|thiocyanate peroxidase activity;","K12550","LPO; lactoperoxidase [EC:1.11.1.7]"]
["ENSRNOG00000063814",18,1.494479889,2,0.128660876,11.61565141,3.537998158,{"v":2.00019e-05,"d":"2.00E-05"},{"v":2.58111e-05,"d":"2.58E-05"},"up","yes","ENSRNOG00000063814","lncRNA","chr14:9055596-9060265:+","gi|537176391|gb|ERE75120.1|",213,{"v":4e-16,"d":"4.00E-16"},"IQ domain-containing protein H [Cricetulus griseus]","gi|49615115|gb|AC118414.9|",184,{"v":7e-89,"d":"7.00E-89"},"Rattus norvegicus 3 BAC CH230-223K21 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam05187","ETF_QO","Electron transfer flavoprotein-ubiquinone oxidoreductase. Electron-transfer flavoprotein-ubiquinone oxidoreductase (ETF-QO) in the inner mitochondrial membrane accepts electrons from electron-transfer flavoprotein which is located in the mitochondrial matrix and reduces ubiquinone in the mitochondrial membrane. The two redox centres in the protein, FAD and a [4Fe4S] cluster, are present in a 64-kDa monomer.",".",".",".",".","."]
["ENSRNOG00000016203",46,3.819226384,20,1.286608764,2.968444248,1.569707017,{"v":2.09609e-05,"d":"2.10E-05"},{"v":2.69778e-05,"d":"2.70E-05"},"up","yes","Efna2","protein_coding","chr7:9516429-9527061:-","gi|247269362|ref|NP_031935.3|",1043,{"v":4e-139,"d":"4.00E-139"},"ephrin-A2 precursor [Mus musculus]","gi|274327666|ref|NM_001168670.1|",1177,0,"Rattus norvegicus ephrin A2 (Efna2), mRNA","P52801",406,{"v":1e-140,"d":"1.00E-140"},"Ephrin-A2",".",".",".",".","pfam00812","Ephrin","Ephrin.","GO:0007411|axon guidance;GO:0021772|olfactory bulb development;GO:0030316|osteoclast differentiation;GO:0042472|inner ear morphogenesis;GO:0046849|bone remodeling;GO:0048013|ephrin receptor signaling pathway;","GO:0005886|plasma membrane;GO:0031225|anchored component of membrane;GO:0031594|neuromuscular junction;GO:0043204|perikaryon;","GO:0046875|ephrin receptor binding;","K05462","EFNA; ephrin-A"]
["ENSRNOG00000025423",46,3.819226384,20,1.286608764,2.968444248,1.569707017,{"v":2.09609e-05,"d":"2.10E-05"},{"v":2.69778e-05,"d":"2.70E-05"},"up","yes","Map3k13","protein_coding","chr11:79097247-79235181:-","gi|198386339|ref|NP_001014000.2|",4216,0,"mitogen-activated protein kinase kinase kinase 13 [Rattus norvegicus]","gi|198386338|ref|NM_001013978.2|",3448,0,"Rattus norvegicus mitogen-activated protein kinase kinase kinase 13 (Map3k13), mRNA","Q1HKZ5",1558,0,"Mitogen-activated protein kinase kinase kinase 13",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0006468|protein phosphorylation;GO:0007254|JNK cascade;GO:0014042|positive regulation of neuron maturation;GO:0018105|peptidyl-serine phosphorylation;GO:0043507|positive regulation of JUN kinase activity;GO:0045773|positive regulation of axon extension;GO:0045860|positive regulation of protein kinase activity;GO:0046777|protein autophosphorylation;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051403|stress-activated MAPK cascade;GO:0150012|positive regulation of neuron projection arborization;GO:1905492|positive regulation of branching morphogenesis of a nerve;","GO:0005737|cytoplasm;GO:0016020|membrane;","GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0004706|JUN kinase kinase kinase activity;GO:0004709|MAP kinase kinase kinase activity;GO:0005524|ATP binding;GO:0019899|enzyme binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0106137|IkappaB kinase complex binding;","K04422","MAP3K13, LZK; mitogen-activated protein kinase kinase kinase 13 [EC:2.7.11.25]"]
["ENSRNOG00000004786",56,4.649492989,28,1.801252269,2.581255868,1.368073156,{"v":2.26915e-05,"d":"2.27E-05"},{"v":2.89952E-5,"d":"2.90E-05"},"up","yes","Cyp4f1","protein_coding","chr7:12010852-12022046:-","gi|52138603|ref|NP_062569.2|",2730,0,"cytochrome P450 4F1 [Rattus norvegicus]","gi|52138602|ref|NM_019623.2|",2091,0,"Rattus norvegicus cytochrome P450, family 4, subfamily f, polypeptide 1 (Cyp4f1), mRNA","P33274",1049,0,"Cytochrome P450 4F1","AGc2890",157,{"v":2e-40,"d":"2.00E-40"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0006690|icosanoid metabolic process;GO:0009636|response to toxic substance;GO:0019369|arachidonic acid metabolic process;GO:0036101|leukotriene B4 catabolic process;GO:0042361|menaquinone catabolic process;GO:0042376|phylloquinone catabolic process;GO:0042377|vitamin K catabolic process;GO:0097267|omega-hydroxylase P450 pathway;","GO:0005789|endoplasmic reticulum membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0004497|monooxygenase activity;GO:0005506|iron ion binding;GO:0008391|arachidonic acid monooxygenase activity;GO:0016705|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0020037|heme binding;GO:0050051|leukotriene-B4 20-monooxygenase activity;GO:0050544|arachidonic acid binding;","K00490","CYP4F; cytochrome P450 family 4 subfamily F [EC:1.14.14.1]"]
["ENSRNOG00000039357",27,2.241719834,7,0.450313067,4.978136317,2.315605736,{"v":2.38672e-05,"d":"2.39E-05"},{"v":3.04488e-05,"d":"3.04E-05"},"up","yes","Niban3","protein_coding","chr16:18307221-18318585:+","gi|261245027|ref|NP_001094378.1|",2375,0,"niban-like protein 2 [Rattus norvegicus]","gi|261245026|ref|NM_001100908.1|",2193,0,"Rattus norvegicus family with sequence similarity 129, member C (Fam129c), mRNA",".",".",".",".",".",".",".",".","pfam15449","Retinal","Retinal protein. This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.",".",".",".",".","."]
["ENSRNOG00000026203",69,5.728839576,39,2.508887089,2.283418652,1.191195394,{"v":2.41972e-05,"d":"2.42E-05"},{"v":3.08452e-05,"d":"3.08E-05"},"up","yes","Pax8","protein_coding","chr3:7185723-7242363:-","gi|77020244|ref|NP_112403.2|",2032,0,"paired box protein Pax-8 [Rattus norvegicus]","gi|77020243|ref|NM_031141.2|",2484,0,"Rattus norvegicus paired box 8 (Pax8), mRNA","P51974",787,0,"Paired box protein Pax-8",".",".",".",".","pfam00292","PAX","'Paired box' domain.","GO:0001655|urogenital system development;GO:0001656|metanephros development;GO:0001658|branching involved in ureteric bud morphogenesis;GO:0001822|kidney development;GO:0001823|mesonephros development;GO:0003281|ventricular septum development;GO:0003337|mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0006351|transcription, DNA-templated;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006790|sulfur compound metabolic process;GO:0007417|central nervous system development;GO:0010667|negative regulation of cardiac muscle cell apoptotic process;GO:0030154|cell differentiation;GO:0030878|thyroid gland development;GO:0039003|pronephric field specification;GO:0042472|inner ear morphogenesis;GO:0042981|regulation of apoptotic process;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048793|pronephros development;GO:0048856|anatomical structure development;GO:0071371|cellular response to gonadotropin stimulus;GO:0071599|otic vesicle development;GO:0072050|S-shaped body morphogenesis;GO:0072073|kidney epithelium development;GO:0072108|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0072164|mesonephric tubule development;GO:0072207|metanephric epithelium development;GO:0072221|metanephric distal convoluted tubule development;GO:0072278|metanephric comma-shaped body morphogenesis;GO:0072284|metanephric S-shaped body morphogenesis;GO:0072289|metanephric nephron tubule formation;GO:0072305|negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis;GO:0072307|regulation of metanephric nephron tubule epithelial cell differentiation;GO:0090190|positive regulation of branching involved in ureteric bud morphogenesis;GO:1900212|negative regulation of mesenchymal cell apoptotic process involved in metanephros development;GO:1900215|negative regulation of apoptotic process involved in metanephric collecting duct development;GO:1900218|negative regulation of apoptotic process involved in metanephric nephron tubule development;GO:2000594|positive regulation of metanephric DCT cell differentiation;GO:2000611|positive regulation of thyroid hormone generation;GO:2000612|regulation of thyroid-stimulating hormone secretion;","GO:0005634|nucleus;GO:0005654|nucleoplasm;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0005515|protein binding;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09293","PAX8; paired box protein 8"]
["ENSRNOG00000033906",79,6.559106181,48,3.087861033,2.124158475,1.086891404,{"v":2.70039e-05,"d":"2.70E-05"},{"v":3.42455e-05,"d":"3.42E-05"},"up","yes","Zfp667","protein_coding","chr1:67601807-67622041:-","gi|56676352|ref|NP_001008557.1|",3112,0,"zinc finger protein 667 [Rattus norvegicus]","gi|56676351|ref|NM_001008557.1|",3380,0,"Rattus norvegicus zinc finger protein 667 (Zfp667), mRNA","Q5MYW4",1201,0,"Zinc finger protein 667",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006357|regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0046872|metal ion binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSRNOG00000037668",65,5.396732934,36,2.315895775,2.330300436,1.220515968,{"v":2.94678e-05,"d":"2.95E-05"},{"v":3.72372e-05,"d":"3.72E-05"},"up","yes","Ccdc162","protein_coding","chr20:45032752-45236193:-","gi|755533308|ref|XP_011241531.1|",9508,0,"PREDICTED: coiled-coil domain containing 162 isoform X2 [Mus musculus]","gi|564322379|ref|XM_006223934.1|",4463,0,"PREDICTED: Rattus norvegicus coiled-coil domain-containing protein 162-like (LOC102554658), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam15082","DUF4549","Domain of unknown function (DUF4549). This family of proteins is found in eukaryotes. Proteins in this family are typically between 143 and 1871 amino acids in length. The human member of this family is C6orf183.",".",".",".",".","."]
["ENSRNOG00000051169",49,4.068306366,23,1.479600078,2.749598642,1.459221044,{"v":3.17158e-05,"d":"3.17E-05"},{"v":3.98809E-5,"d":"3.99E-05"},"up","yes","Clnk","protein_coding","chr14:71873105-72101208:+","gi|564384052|ref|XP_006251168.1|",2240,0,"PREDICTED: cytokine-dependent hematopoietic cell linker isoform X5 [Rattus norvegicus]","gi|672076488|ref|XM_006251106.2|",1937,0,"PREDICTED: Rattus norvegicus cytokine-dependent hematopoietic cell linker (Clnk), transcript variant X5, mRNA","Q9QZE2",683,0,"Cytokine-dependent hematopoietic cell linker",".",".",".",".","pfam00017","SH2","SH2 domain.","GO:0002729|positive regulation of natural killer cell cytokine production;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0010941|regulation of cell death;GO:0032815|negative regulation of natural killer cell activation;GO:0035556|intracellular signal transduction;GO:0043303|mast cell degranulation;","GO:0005737|cytoplasm;GO:0032991|protein-containing complex;GO:0042629|mast cell granule;","GO:0044877|protein-containing complex binding;",".","."]
["ENSRNOG00000064855",49,4.068306366,23,1.479600078,2.749598642,1.459221044,{"v":3.17158e-05,"d":"3.17E-05"},{"v":3.98809E-5,"d":"3.99E-05"},"up","yes","ENSRNOG00000064855","lncRNA","chr2:183842051-183844322:+","gi|149030597|gb|EDL85634.1|",176,{"v":2E-12,"d":"2.00E-12"},"rCG52010, isoform CRA_a [Rattus norvegicus]","gi|51262144|gb|BC079138.1|",250,{"v":3e-126,"d":"3.00E-126"},"Rattus norvegicus cDNA clone IMAGE:7127764",".",".",".",".",".",".",".",".","pfam09863","DUF2090","Uncharacterized protein conserved in bacteria (DUF2090). This domain, found in various prokaryotic carbohydrate kinases, has no known function.",".",".",".",".","."]
["ENSRNOG00000034093",37,3.071986439,14,0.900626135,3.410945254,1.7701716,{"v":3.23934e-05,"d":"3.24E-05"},{"v":4.06929e-05,"d":"4.07E-05"},"up","yes","AABR07011951.1","protein_coding","chr2:164044261-164046336:+","gi|676282501|gb|KFO35963.1|",3008,0,"Heat shock cognate 71 kDa protein [Fukomys damarensis]","gi|149879639|ref|NG_004796.2|",2032,0,"Rattus norvegicus heat shock cognate protein 70, pseudogene 1 (Hsc70-ps1) on chromosome 2","P63018",1152,0,"Heat shock cognate 71 kDa protein",".",".",".",".","pfam00012","HSP70","Hsp70 protein. Hsp70 chaperones help to fold many proteins. Hsp70 assisted folding involves repeated cycles of substrate binding and release. Hsp70 activity is ATP dependent. Hsp70 proteins are made up of two regions: the amino terminus is the ATPase domain and the carboxyl terminus is the substrate binding region.","GO:0072318|clathrin coat disassembly;",".",".",".","."]
["ENSRNOG00000021260",23,1.909613192,5,0.321652191,5.936888496,2.569707017,{"v":3.45429e-05,"d":"3.45E-05"},{"v":4.32148e-05,"d":"4.32E-05"},"up","yes","Prnd","protein_coding","chr3:119213429-119218745:+","gi|564343103|ref|XP_006235118.1|",903,{"v":1e-110,"d":"1.00E-110"},"PREDICTED: prion-like protein doppel isoform X2 [Rattus norvegicus]","gi|672046747|ref|XM_006235058.2|",1759,0,"PREDICTED: Rattus norvegicus prion protein 2 (dublet) (Prnd), transcript variant X3, mRNA","Q9QUG3",319,{"v":6e-100,"d":"6.00E-100"},"Prion-like protein doppel",".",".",".",".","pfam00377","Prion","Prion/Doppel alpha-helical domain. The prion protein is thought to be the infectious agent that causes transmissible spongiform encephalopathies, such as scrapie and BSE. It is thought that the prion protein can exist in two different forms: one is the normal cellular protein, and the other is the infectious form which can change the normal prion protein into the infectious form. It has been found that the prion alpha-helical domain is also found in the Doppel protein.","GO:0006878|cellular copper ion homeostasis;GO:0007338|single fertilization;GO:0007340|acrosome reaction;GO:0051260|protein homooligomerization;","GO:0031362|anchored component of external side of plasma membrane;","GO:0005507|copper ion binding;",".","."]
["ENSRNOG00000016632",15,1.245399908,1,0.064330438,19.35941901,4.274963752,{"v":3.4691e-05,"d":"3.47E-05"},{"v":4.33831e-05,"d":"4.34E-05"},"up","yes","Dsg3","protein_coding","chr18:11798900-11830818:+","gi|672082682|ref|XP_008770156.1|",5086,0,"PREDICTED: desmoglein-3 isoform X1 [Rattus norvegicus]","gi|672082681|ref|XM_008771934.1|",2739,0,"PREDICTED: Rattus norvegicus desmoglein 3 (Dsg3), transcript variant X1, mRNA","O35902",1717,0,"Desmoglein-3",".",".",".",".","pfam00028","Cadherin","Cadherin domain.","GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0098609|cell-cell adhesion;","GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0016021|integral component of membrane;GO:0030057|desmosome;","GO:0005509|calcium ion binding;","K07598","DSG3; desmoglein 3"]
["ENSRNOG00000057404",15,1.245399908,1,0.064330438,19.35941901,4.274963752,{"v":3.4691e-05,"d":"3.47E-05"},{"v":4.33831e-05,"d":"4.34E-05"},"up","yes","Slc47a1","protein_coding","chr10:46034122-46087637:-","gi|62078965|ref|NP_001014140.1|",2368,0,"multidrug and toxin extrusion protein 1 [Rattus norvegicus]","gi|298891883|emb|FQ217802.1|",2517,0,"Rattus norvegicus TL0ACA17YG10 mRNA sequence","Q5I0E9",916,0,"Multidrug and toxin extrusion protein 1","SPCC4B3.13",220,{"v":4e-60,"d":"4.00E-60"},"COG0534","pfam01554","MatE","MatE. The MatE domain","GO:0006812|cation transport;GO:0015695|organic cation transport;GO:0042886|amide transport;GO:0042908|xenobiotic transport;GO:0055085|transmembrane transport;GO:0089718|amino acid import across plasma membrane;GO:0097638|L-arginine import across plasma membrane;GO:0098655|cation transmembrane transport;GO:1902475|L-alpha-amino acid transmembrane transport;GO:1990961|drug transmembrane export;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0031982|vesicle;","GO:0015179|L-amino acid transmembrane transporter activity;GO:0015297|antiporter activity;GO:0022857|transmembrane transporter activity;GO:0042887|amide transmembrane transporter activity;GO:0042910|xenobiotic transmembrane transporter activity;GO:0061459|L-arginine transmembrane transporter activity;","K03327","TC.MATE, SLC47A, norM, mdtK, dinF; multidrug resistance protein, MATE family"]
["ENSRNOG00000001527",76,6.3100262,46,2.959200157,2.132341804,1.092438714,{"v":3.56609e-05,"d":"3.57E-05"},{"v":4.44829e-05,"d":"4.45E-05"},"up","yes","Cd80","protein_coding","chr11:62254624-62292030:-","gi|2853281|gb|AAC02262.1|",1358,{"v":2E-176,"d":"2.00E-176"},"CD80 [Rattus norvegicus]","gi|672071070|ref|XM_006248365.2|",1385,0,"PREDICTED: Rattus norvegicus Cd80 molecule (Cd80), transcript variant X1, mRNA","Q00609",352,{"v":7e-111,"d":"7.00E-111"},"T-lymphocyte activation antigen CD80",".",".",".",".","pfam08205","C2-set_2","CD80-like C2-set immunoglobulin domain. These domains belong to the immunoglobulin superfamily.","GO:0006955|immune response;GO:0007166|cell surface receptor signaling pathway;GO:0031295|T cell costimulation;GO:0042102|positive regulation of T cell proliferation;GO:0042130|negative regulation of T cell proliferation;GO:0046641|positive regulation of alpha-beta T cell proliferation;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0071222|cellular response to lipopolysaccharide;","GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0098636|protein complex involved in cell adhesion;","GO:0003674|molecular_function;GO:0015026|coreceptor activity;","K05412","CD80; CD80 antigen"]
["ENSRNOG00000010798",21,1.743559871,4,0.257321753,6.775796653,2.760390579,{"v":3.91284e-05,"d":"3.91E-05"},{"v":4.85763e-05,"d":"4.86E-05"},"up","yes","Blk","protein_coding","chr15:37627039-37665031:-","gi|672078356|ref|XP_008768991.1|",2575,0,"PREDICTED: tyrosine-protein kinase Blk isoform X2 [Rattus norvegicus]","gi|71043711|ref|NM_001025751.1|",2264,0,"Rattus norvegicus BLK proto-oncogene, Src family tyrosine kinase (Blk), mRNA","P16277",967,0,"Tyrosine-protein kinase Blk",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0002431|Fc receptor mediated stimulatory signaling pathway;GO:0002513|tolerance induction to self antigen;GO:0002576|platelet degranulation;GO:0002902|regulation of B cell apoptotic process;GO:0006974|cellular response to DNA damage stimulus;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0008150|biological_process;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0030154|cell differentiation;GO:0030889|negative regulation of B cell proliferation;GO:0031175|neuron projection development;GO:0032024|positive regulation of insulin secretion;GO:0032092|positive regulation of protein binding;GO:0043304|regulation of mast cell degranulation;GO:0045087|innate immune response;GO:0050853|B cell receptor signaling pathway;GO:0050855|regulation of B cell receptor signaling pathway;GO:0070667|negative regulation of mast cell proliferation;GO:0090330|regulation of platelet aggregation;GO:0097028|dendritic cell differentiation;GO:2000670|positive regulation of dendritic cell apoptotic process;","GO:0005575|cellular_component;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;","GO:0003674|molecular_function;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0005102|signaling receptor binding;GO:0005524|ATP binding;","K08890","BLK; B lymphoid tyrosine kinase [EC:2.7.10.2]"]
["ENSRNOG00000067363",17,1.411453229,2,0.128660876,10.97033744,3.455535997,{"v":4.01931E-5,"d":"4.02E-05"},{"v":4.98157e-05,"d":"4.98E-05"},"up","yes","Xkrx","protein_coding","chrX:97341152-97354759:-","gi|58866038|ref|NP_001012230.1|",2200,0,"XK-related protein 2 [Rattus norvegicus]","gi|58866037|ref|NM_001012230.1|",1800,0,"Rattus norvegicus XK related, X-linked (Xkrx), mRNA","Q5GH60",852,0,"XK-related protein 2",".",".",".",".","pfam09815","XK-related","XK-related protein. Members of this family comprise various XK-related proteins, that are involved in sodium-dependent transport of neutral amino acids or oligopeptides. These proteins are responsible for the Kx blood group system - defects results in McLeod syndrome, an X-linked multi-system disorder characterized by late onset abnormalities in the neuromuscular and hematopoietic systems.",".",".",".",".","."]
["ENSRNOG00000071206",17,1.411453229,2,0.128660876,10.97033744,3.455535997,{"v":4.01931E-5,"d":"4.02E-05"},{"v":4.98157e-05,"d":"4.98E-05"},"up","yes","ENSRNOG00000071206","lncRNA","chrX:68541121-68542702:-","gi|344250225|gb|EGW06329.1|",137,3e-07,"hypothetical protein I79_018985 [Cricetulus griseus]","gi|44844357|emb|AL844607.4|",92,{"v":3e-38,"d":"3.00E-38"},"Mouse DNA sequence from clone RP24-280G18 on chromosome 4, complete sequence",".",".",".",".",".",".",".",".","pfam12966","AtpR","N-ATPase, AtpR subunit. Membrane protein with three predicted transmembrane segments, two of which contain conserved Arg residues. AtpR genes are found in the N-ATPase (archaeal-type F1-Fo-ATPase) operons and are predicted to interact with the conserved Glu/Asp residues in the c subunits, regulating the assembly and/or function of the membrane-embedded ring of 'c' (proteolipid) subunits (pfam00137).",".",".",".",".","."]
["ENSRNOG00000065219",19,1.57750655,3,0.192991315,8.173976915,3.031038169,{"v":4.15704e-05,"d":"4.16E-05"},{"v":5.1443e-05,"d":"5.14E-05"},"up","yes","ENSRNOG00000065219","protein_coding","chr20:2704465-2705186:+","gi|148692636|gb|EDL24583.1|",141,{"v":9e-10,"d":"9.00E-10"},"mCG130546, isoform CRA_b, partial [Mus musculus]","gi|672085499|ref|XR_361987.2|",223,{"v":9e-112,"d":"9.00E-112"},"PREDICTED: Rattus norvegicus uncharacterized LOC102549760 (LOC102549760), transcript variant X2, ncRNA",".",".",".",".",".",".",".",".","pfam00940","RNA_pol","DNA-dependent RNA polymerase. This is a family of single chain RNA polymerases.",".",".",".",".","."]
["ENSRNOG00000019363",57,4.73251965,30,1.929913146,2.452193075,1.294072575,{"v":4.21707e-05,"d":"4.22E-05"},{"v":5.21554e-05,"d":"5.22E-05"},"up","yes","Inka1","protein_coding","chr8:108674263-108675953:-","gi|157823932|ref|NP_001101657.1|",1200,{"v":2e-162,"d":"2.00E-162"},"protein FAM212A [Rattus norvegicus]","gi|157823931|ref|NM_001108187.1|",1062,0,"Rattus norvegicus family with sequence similarity 212, member A (Fam212a), mRNA","Q9CX62",445,{"v":2E-155,"d":"2.00E-155"},"PAK4-inhibitor INKA1",".",".",".",".","pfam15342","FAM212","FAM212 family. This domain family is found in eukaryotes, and is approximately 60 amino acids in length.","GO:0021915|neural tube development;GO:0043086|negative regulation of catalytic activity;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0019901|protein kinase binding;GO:0030291|protein serine/threonine kinase inhibitor activity;",".","."]
["ENSRNOG00000068198",26,2.158693174,7,0.450313067,4.793760898,2.261157952,{"v":4.3669e-05,"d":"4.37E-05"},{"v":5.39667E-5,"d":"5.40E-05"},"up","yes","C1H19orf84","protein_coding","chr1:93835395-93836380:+","gi|672013483|ref|XP_008772738.1|",557,{"v":2e-69,"d":"2.00E-69"},"PREDICTED: uncharacterized protein C19orf84 homolog [Rattus norvegicus]","gi|672013482|ref|XM_008774516.1|",540,0,"PREDICTED: Rattus norvegicus chromosome 1 open reading frame, human C19orf84 (C1H19orf84), mRNA",".",".",".",".",".",".",".",".","pfam12385","Peptidase_C70","Papain-like cysteine protease AvrRpt2. This is a family of cysteine proteases, found in actinobacteria, protobacteria and firmicutes. Papain-like cysteine proteases play a crucial role in plant-pathogen/pest interactions. On entering the host they act on non-self substrates, thereby manipulating the host to evade proteolysis. AvrRpt2 from Pseudomonas syringae pv. tomato DC3000 triggers resistance to P. syringae-2-dependent defence responses, including hypersensitive cell death, by cleaving the Arabidopsis RIN4 protein which is monitored by the cognate resistance protein RPS2.",".",".",".",".","."]
["ENSRNOG00000009487",43,3.570146403,19,1.222278326,2.920894798,1.546410397,{"v":4.72809e-05,"d":"4.73E-05"},{"v":5.81718e-05,"d":"5.82E-05"},"up","yes","Gpr160","protein_coding","chr2:112484935-112563148:-","gi|68341997|ref|NP_001020318.1|",1578,0,"probable G-protein coupled receptor 160 [Rattus norvegicus]","gi|672042140|ref|XM_008760935.1|",2513,0,"PREDICTED: Rattus norvegicus G protein-coupled receptor 160 (Gpr160), transcript variant X1, mRNA","Q66H29",612,0,"Probable G-protein coupled receptor 160",".",".",".",".","pfam06736","DUF1211","Protein of unknown function (DUF1211). This family represents a conserved region within a number of hypothetical proteins of unknown function found in eukaryotes, bacteria and archaea. These may possibly be integral membrane proteins.","GO:0007186|G protein-coupled receptor signaling pathway;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0043235|receptor complex;","GO:0004930|G protein-coupled receptor activity;","K08438","GPR160; G protein-coupled receptor 160"]
["ENSRNOG00000025251",74,6.143972879,45,2.894869718,2.122365936,1.085673425,{"v":4.93532E-5,"d":"4.94E-05"},{"v":6.05351e-05,"d":"6.05E-05"},"up","yes","H1f8","protein_coding","chr4:148993133-148998254:+","gi|157819381|ref|NP_001102821.1|",1499,0,"H1 histone family, member O, oocyte-specific [Rattus norvegicus]","gi|157819380|ref|NM_001109351.1|",1149,0,"Rattus norvegicus H1 histone family, member O, oocyte-specific (H1foo), mRNA","Q8VIK3",403,{"v":3e-138,"d":"3.00E-138"},"Histone H1oo",".",".",".",".","pfam00538","Linker_histone","linker histone H1 and H5 family. Linker histone H1 is an essential component of chromatin structure. H1 links nucleosomes into higher order structures Histone H1 is replaced by histone H5 in some cell types.","GO:0006334|nucleosome assembly;GO:0016584|nucleosome positioning;GO:0030261|chromosome condensation;GO:0044030|regulation of DNA methylation;GO:0045910|negative regulation of DNA recombination;GO:2000737|negative regulation of stem cell differentiation;","GO:0000786|nucleosome;GO:0001674|female germ cell nucleus;GO:0005634|nucleus;","GO:0003690|double-stranded DNA binding;GO:0031492|nucleosomal DNA binding;",".","."]
["ENSRNOG00000038574",74,6.143972879,45,2.894869718,2.122365936,1.085673425,{"v":4.93532E-5,"d":"4.94E-05"},{"v":6.05351e-05,"d":"6.05E-05"},"up","yes","Rassf9","protein_coding","chr7:37599720-37635245:+","gi|149067056|gb|EDM16789.1|",2215,0,"peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor [Rattus norvegicus]","gi|354790070|gb|JN954571.1|",1522,0,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Rassf9:tm1e(KOMP)Ucd; transgenic","O88869",856,0,"Ras association domain-containing protein 9",".",".",".",".","pfam12009","Telomerase_RBD","Telomerase ribonucleoprotein complex - RNA binding domain. Telomeres in most organisms are comprised of tandem simple sequence repeats. The total length of telomeric repeat sequence at each chromosome end is determined in a balance of sequence loss and sequence addition. One major influence on telomere length is the enzyme telomerase. It is a reverse transcriptase that adds these simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. The RNA binding domain of telomerase - TRBD - is made up of twelve alpha helices and two short beta sheets. How telomerase and associated regulatory factors physically interact and function with each other to maintain appropriate telomere length is poorly understood. It is known however that TRBD is involved in formation of the holoenzyme (which performs the telomere extension) in addition to recognition and binding of RNA.","GO:0006605|protein targeting;GO:0007165|signal transduction;GO:0016197|endosomal transport;GO:0046907|intracellular transport;","GO:0005768|endosome;GO:0005829|cytosol;GO:0012510|trans-Golgi network transport vesicle membrane;GO:0055037|recycling endosome;","GO:0004497|monooxygenase activity;GO:0005515|protein binding;GO:0019899|enzyme binding;GO:0019904|protein domain specific binding;","K09856","RASSF9_10; Ras association domain-containing protein 9/10"]
["ENSRNOG00000012989",36,2.988959779,14,0.900626135,3.318757544,1.730643236,{"v":5.45063e-05,"d":"5.45E-05"},{"v":6.63593E-5,"d":"6.64E-05"},"up","yes","Serinc2","protein_coding","chr5:142592309-142618364:-","gi|72255537|ref|NP_001026826.1|",1967,0,"serine incorporator 2 precursor [Rattus norvegicus]","gi|72255536|ref|NM_001031656.1|",1803,0,"Rattus norvegicus serine incorporator 2 (Serinc2), mRNA","Q8K0E7",747,0,"Serine incorporator 2",".",".",".",".","pfam03348","Serinc","Serine incorporator (Serinc). This is a family of eukaryotic membrane proteins which incorporate serine into membranes and facilitate the synthesis of the serine-derived lipids phosphatidylserine and sphingolipid. Members of this family contain 11 transmembrane domains and form intracellular complexes with key enzymes involved in serine and sphingolipid biosynthesis.","GO:0006658|phosphatidylserine metabolic process;GO:0006665|sphingolipid metabolic process;GO:1904219|positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity;GO:1904222|positive regulation of serine C-palmitoyltransferase activity;","GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0030674|protein binding, bridging;","K24176","SERINC2; serine incorporator 2"]
["ENSRNOG00000026594",36,2.988959779,14,0.900626135,3.318757544,1.730643236,{"v":5.45063e-05,"d":"5.45E-05"},{"v":6.63593E-5,"d":"6.64E-05"},"up","yes","Tmem61","protein_coding","chr5:121266799-121276057:-","gi|564305792|ref|XP_006225489.1|",885,{"v":8E-116,"d":"8.00E-116"},"PREDICTED: transmembrane protein 61 [Rattus norvegicus]","gi|672019676|ref|XM_006225427.2|",1074,0,"PREDICTED: Rattus norvegicus uncharacterized LOC100909776 (LOC100909776), mRNA","Q8N0U2",138,{"v":5e-37,"d":"5.00E-37"},"Transmembrane protein 61",".",".",".",".","pfam15105","TMEM61","TMEM61 protein family. The function of this family of transmembrane proteins has not, as yet, been determined. Members of this family remain uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 150 and 211 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000021560",40,3.321066421,17,1.093617449,3.036771609,1.60253841,{"v":5.64331E-5,"d":"5.64E-05"},{"v":6.85484e-05,"d":"6.85E-05"},"up","yes","Cass4","protein_coding","chr3:161163436-161202186:+","gi|564344734|ref|XP_006235741.1|",4005,0,"PREDICTED: cas scaffolding protein family member 4 isoform X1 [Rattus norvegicus]","gi|672048056|ref|XM_006235679.2|",3610,0,"PREDICTED: Rattus norvegicus Cas scaffolding protein family member 4 (Cass4), transcript variant X1, mRNA","Q08EC4",1264,0,"Cas scaffolding protein family member 4",".",".",".",".","pfam08824","Serine_rich","Serine rich protein interaction domain. This is a serine rich domain that is found in the docking protein p130(cas) (Crk-associated substrate). This domain folds into a four helix bundle which is associated with protein-protein interactions.","GO:0007155|cell adhesion;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0016477|cell migration;GO:0030335|positive regulation of cell migration;GO:0051897|positive regulation of protein kinase B signaling;GO:0061098|positive regulation of protein tyrosine kinase activity;GO:0090527|actin filament reorganization;GO:1900026|positive regulation of substrate adhesion-dependent cell spreading;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005925|focal adhesion;","GO:1990782|protein tyrosine kinase binding;",".","."]
["ENSRNOG00000037339",33,2.739879797,12,0.771965258,3.549226818,1.827504775,{"v":6.02202e-05,"d":"6.02E-05"},{"v":7.27753e-05,"d":"7.28E-05"},"up","yes","Siglec10","protein_coding","chr1:93817335-93825931:+","gi|564327834|ref|XP_006229010.1|",3455,0,"PREDICTED: sialic acid-binding Ig-like lectin 10 isoform X1 [Rattus norvegicus]","gi|672036310|ref|XM_006228948.2|",2498,0,"PREDICTED: Rattus norvegicus sialic acid binding Ig-like lectin 10 (Siglec10), transcript variant X1, mRNA","Q80ZE3",1113,0,"Sialic acid-binding Ig-like lectin 10",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0002244|hematopoietic progenitor cell differentiation;GO:0002638|negative regulation of immunoglobulin production;GO:0007155|cell adhesion;GO:0030888|regulation of B cell proliferation;GO:0050776|regulation of immune response;GO:0050849|negative regulation of calcium-mediated signaling;GO:0106015|negative regulation of inflammatory response to wounding;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0019902|phosphatase binding;GO:0030246|carbohydrate binding;GO:0033691|sialic acid binding;GO:0042169|SH2 domain binding;","K06749","SIGLEC10; sialic acid binding Ig-like lectin 10"]
["ENSRNOG00000058912",45,3.736199724,21,1.350939202,2.765631287,1.46760883,{"v":6.21659e-05,"d":"6.22E-05"},{"v":7.49426e-05,"d":"7.49E-05"},"up","yes","ENSRNOG00000058912","protein_coding","chr20:5808860-5840172:+","gi|114145706|ref|NP_001041404.1|",2899,0,"uncharacterized protein LOC499407 [Rattus norvegicus]","gi|114145705|ref|NM_001047939.1|",2650,0,"Rattus norvegicus LRRGT00097 (LOC499407), mRNA",".",".",".",".",".",".",".",".","pfam11575","FhuF_C","FhuF 2Fe-2S C-terminal domain. This family consists of several bacterial ferric iron reductase protein (FhuF) sequences.  FhuF is involved in the reduction of ferric iron in cytoplasmic ferrioxamine B. This domain is the C-terminal domain that contains 4 conserved cysteine residues that are found to be part of a 2Fe-2S cluster.",".",".",".",".","."]
["ENSRNOG00000037190",30,2.490799816,10,0.643304382,3.871883802,1.953035657,{"v":6.33345e-05,"d":"6.33E-05"},{"v":7.62363e-05,"d":"7.62E-05"},"up","yes","Cd101","protein_coding","chr2:188422351-188459502:-","gi|403420584|ref|NP_001258146.1|",5177,0,"immunoglobulin superfamily member 2 precursor [Rattus norvegicus]","gi|672043656|ref|XM_006233049.2|",3211,0,"PREDICTED: Rattus norvegicus CD101 molecule (Cd101), transcript variant X2, mRNA","A8E0Y8",1749,0,"Immunoglobulin superfamily member 2",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0002763|positive regulation of myeloid leukocyte differentiation;","GO:0016021|integral component of membrane;",".","K06522","IGSF2_3, CD101; immunoglobulin superfamily, member 2/3"]
["ENSRNOG00000015788",13,1.079346587,0,0.032165219,33.55632628,5.068512874,{"v":6.81267e-05,"d":"6.81E-05"},{"v":8.16512e-05,"d":"8.17E-05"},"up","yes","Adora3","protein_coding","chr2:193388713-193392357:+","gi|713693919|ref|NP_001289684.1|",1762,0,"adenosine receptor A3 isoform a [Rattus norvegicus]","gi|713693918|ref|NM_001302755.1|",1815,0,"Rattus norvegicus adenosine A3 receptor (Adora3), transcript variant A3i, mRNA","P28647",618,0,"Adenosine receptor A3",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001973|adenosine receptor signaling pathway;GO:0008285|negative regulation of cell proliferation;GO:0030336|negative regulation of cell migration;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0098685|Schaffer collateral - CA1 synapse;","GO:0001609|G protein-coupled adenosine receptor activity;GO:0004888|transmembrane signaling receptor activity;","K04268","ADORA3; adenosine receptor A3"]
["ENSRNOG00000031024",13,1.079346587,0,0.032165219,33.55632628,5.068512874,{"v":6.81267e-05,"d":"6.81E-05"},{"v":8.16512e-05,"d":"8.17E-05"},"up","yes","Sirpd","protein_coding","chr2:85513491-85702289:+","gi|672041746|ref|XP_008759042.1|",1388,0,"PREDICTED: tyrosine-protein phosphatase non-receptor type substrate 1-like isoform X2 [Rattus norvegicus]","gi|672015586|ref|XM_008775108.1|",781,0,"PREDICTED: Rattus norvegicus signal-regulatory protein delta (Sirpd), transcript variant X1, mRNA","P97797",188,{"v":3E-52,"d":"3.00E-52"},"Tyrosine-protein phosphatase non-receptor type substrate 1",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0050766|positive regulation of phagocytosis;GO:0050870|positive regulation of T cell activation;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000055196",14,1.162373247,1,0.064330438,18.06879108,4.175428078,{"v":7.04648e-05,"d":"7.05E-05"},{"v":8.42639e-05,"d":"8.43E-05"},"up","yes","Klrc1","protein_coding","chr4:163147189-163152425:-","gi|82880672|ref|NP_001032518.1|",1190,{"v":3e-163,"d":"3.00E-163"},"killer cell lectin-like receptor subfamily C, member 1 [Rattus norvegicus]","gi|148877816|gb|BC145694.1|",489,0,"Mus musculus killer cell lectin-like receptor subfamily C, member 1, mRNA (cDNA clone MGC:175581 IMAGE:40130997), complete cds","Q9MZJ3",189,{"v":2e-57,"d":"2.00E-57"},"NKG2-A/NKG2-B type II integral membrane protein",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0001915|negative regulation of T cell mediated cytotoxicity;GO:0002305|CD8-positive, gamma-delta intraepithelial T cell differentiation;GO:0002769|natural killer cell inhibitory signaling pathway;GO:0008150|biological_process;GO:0045953|negative regulation of natural killer cell mediated cytotoxicity;","GO:0005575|cellular_component;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0043235|receptor complex;","GO:0003674|molecular_function;GO:0023024|MHC class I protein complex binding;","K06541","KLRC1, NKG2A; killer cell lectin-like receptor subfamily C1"]
["ENSRNOG00000066355",14,1.162373247,1,0.064330438,18.06879108,4.175428078,{"v":7.04648e-05,"d":"7.05E-05"},{"v":8.42639e-05,"d":"8.43E-05"},"up","yes","ENSRNOG00000066355","lncRNA","chr1:38662883-38683131:-","gi|672072106|ref|XP_006248795.2|",581,{"v":2e-96,"d":"2.00E-96"},"PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC302022 isoform X1 [Rattus norvegicus]","gi|672021287|ref|XR_601634.1|",2641,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103695335 (LOC103695335), ncRNA","B5DFC9",197,{"v":4e-80,"d":"4.00E-80"},"Nidogen-2",".",".",".",".","pfam02948","Amelogenin","Amelogenin. Amelogenins play a role in biomineralisation. They seem to regulate the formation of crystallites during the secretory stage of tooth enamel development. thought to play a major role in the structural organisation and mineralisation of developing enamel. They are found in the extracellular matrix. Mutations in X-chromosomal amelogenin can cause Amelogenesis imperfecta.",".",".",".",".","."]
["ENSRNOG00000020998",42,3.487119742,19,1.222278326,2.852967012,1.512463066,{"v":7.62089e-05,"d":"7.62E-05"},{"v":9.07257e-05,"d":"9.07E-05"},"up","yes","AABR07006283.1","protein_coding","chr1:208516050-208541026:-","gi|672014886|ref|XP_008773042.1|",941,{"v":3e-126,"d":"3.00E-126"},"PREDICTED: LOW QUALITY PROTEIN: oocyte-secreted protein 1-like [Rattus norvegicus]","gi|672014885|ref|XM_008774820.1|",523,0,"PREDICTED: Rattus norvegicus oocyte secreted protein 1 (Oosp1), mRNA","Q925U0",294,{"v":7e-100,"d":"7.00E-100"},"Oocyte-secreted protein 1",".",".",".",".","pfam07888","CALCOCO1","Calcium binding and coiled-coil domain (CALCOCO1) like. Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.",".",".",".",".","."]
["ENSRNOG00000000871",16,1.328426568,2,0.128660876,10.32502347,3.368073156,{"v":8.07287e-05,"d":"8.07E-05"},{"v":9.56789e-05,"d":"9.57E-05"},"up","yes","ENSRNOG00000000871","protein_coding","chrX:135126969-135138306:+","gi|117957976|gb|ABK59325.1|",1384,0,"CD40 ligand CD154 [Rattus norvegicus]","gi|117957975|gb|EF066490.1|",783,0,"Rattus norvegicus CD40 ligand CD154 mRNA, complete cds","Q9Z2V2",532,0,"CD40 ligand",".",".",".",".","pfam00229","TNF","TNF(tumor Necrosis Factor) family.","GO:0002637|regulation of immunoglobulin production;GO:0002839|positive regulation of immune response to tumor cell;GO:0006954|inflammatory response;GO:0007229|integrin-mediated signaling pathway;GO:0010628|positive regulation of gene expression;GO:0023035|CD40 signaling pathway;GO:0030168|platelet activation;GO:0030183|B cell differentiation;GO:0030890|positive regulation of B cell proliferation;GO:0032729|positive regulation of interferon-gamma production;GO:0032733|positive regulation of interleukin-10 production;GO:0032735|positive regulation of interleukin-12 production;GO:0032753|positive regulation of interleukin-4 production;GO:0033590|response to cobalamin;GO:0042100|B cell proliferation;GO:0042102|positive regulation of T cell proliferation;GO:0043066|negative regulation of apoptotic process;GO:0045190|isotype switching;GO:0045348|positive regulation of MHC class II biosynthetic process;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0071356|cellular response to tumor necrosis factor;GO:0097028|dendritic cell differentiation;GO:1901652|response to peptide;GO:2000353|positive regulation of endothelial cell apoptotic process;GO:2001200|positive regulation of dendritic cell differentiation;","GO:0005615|extracellular space;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0042995|cell projection;GO:0044297|cell body;","GO:0005125|cytokine activity;GO:0005164|tumor necrosis factor receptor binding;GO:0005174|CD40 receptor binding;GO:0005178|integrin binding;","K03161","TNFSF5, CD40L, CD154; tumor necrosis factor ligand superfamily member 5"]
["ENSRNOG00000004575",16,1.328426568,2,0.128660876,10.32502347,3.368073156,{"v":8.07287e-05,"d":"8.07E-05"},{"v":9.56789e-05,"d":"9.57E-05"},"up","yes","Il1a","protein_coding","chr3:116526604-116536822:-","gi|8393593|ref|NP_058715.1|",1438,0,"interleukin-1 alpha precursor [Rattus norvegicus]","gi|8393592|ref|NM_017019.1|",1987,0,"Rattus norvegicus interleukin 1 alpha (Il1a), mRNA","P16598",558,0,"Interleukin-1 alpha",".",".",".",".","pfam02394","IL1_propep","Interleukin-1 propeptide. The Interleukin-1 cytokines are translated as precursor proteins. The N terminal approx. 115 amino acids form a propeptide that is cleaved off to release the active interleukin-1.","GO:0001660|fever generation;GO:0001666|response to hypoxia;GO:0001819|positive regulation of cytokine production;GO:0002248|connective tissue replacement involved in inflammatory response wound healing;GO:0002526|acute inflammatory response;GO:0006883|cellular sodium ion homeostasis;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007165|signal transduction;GO:0007283|spermatogenesis;GO:0007507|heart development;GO:0008285|negative regulation of cell proliferation;GO:0009408|response to heat;GO:0010033|response to organic substance;GO:0010193|response to ozone;GO:0010243|response to organonitrogen compound;GO:0010332|response to gamma radiation;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0010628|positive regulation of gene expression;GO:0010893|positive regulation of steroid biosynthetic process;GO:0014070|response to organic cyclic compound;GO:0019221|cytokine-mediated signaling pathway;GO:0031424|keratinization;GO:0032308|positive regulation of prostaglandin secretion;GO:0032496|response to lipopolysaccharide;GO:0032743|positive regulation of interleukin-2 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032874|positive regulation of stress-activated MAPK cascade;GO:0032956|regulation of actin cytoskeleton organization;GO:0033092|positive regulation of immature T cell proliferation in thymus;GO:0033591|response to L-ascorbic acid;GO:0034605|cellular response to heat;GO:0035234|ectopic germ cell programmed cell death;GO:0042060|wound healing;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045766|positive regulation of angiogenesis;GO:0045840|positive regulation of mitotic nuclear division;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046330|positive regulation of JNK cascade;GO:0046688|response to copper ion;GO:0050714|positive regulation of protein secretion;GO:0050999|regulation of nitric-oxide synthase activity;GO:0051781|positive regulation of cell division;GO:0051930|regulation of sensory perception of pain;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070498|interleukin-1-mediated signaling pathway;GO:0071222|cellular response to lipopolysaccharide;GO:0071639|positive regulation of monocyte chemotactic protein-1 production;GO:0097192|extrinsic apoptotic signaling pathway in absence of ligand;GO:1902624|positive regulation of neutrophil migration;GO:1904445|negative regulation of establishment of Sertoli cell barrier;GO:2000391|positive regulation of neutrophil extravasation;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0009986|cell surface;","GO:0005125|cytokine activity;GO:0005149|interleukin-1 receptor binding;GO:0005507|copper ion binding;","K04383","IL1A; interleukin 1 alpha"]
["ENSRNOG00000042628",16,1.328426568,2,0.128660876,10.32502347,3.368073156,{"v":8.07287e-05,"d":"8.07E-05"},{"v":9.56789e-05,"d":"9.57E-05"},"up","yes","Tmem273","protein_coding","chr16:8049669-8081981:+","gi|149034139|gb|EDL88909.1|",490,{"v":1e-57,"d":"1.00E-57"},"similar to novel protein (predicted), isoform CRA_b [Rattus norvegicus]","gi|254692852|ref|NM_001134605.2|",1076,0,"Rattus norvegicus similar to novel protein (RGD1561145), mRNA",".",".",".",".",".",".",".",".","pfam14986","DUF4514","Domain of unknown function (DUF4514). This family of uncharacterized proteins are found in mammals.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000052467",16,1.328426568,2,0.128660876,10.32502347,3.368073156,{"v":8.07287e-05,"d":"8.07E-05"},{"v":9.56789e-05,"d":"9.57E-05"},"up","yes","Klrc3","protein_coding","chr4:163122704-163133843:-","gi|9506841|ref|NP_062134.1|",1235,{"v":3e-167,"d":"3.00E-167"},"killer cell lectin-like receptor subfamily C, member 2 [Rattus norvegicus]","gi|9506840|ref|NM_019261.1|",1294,0,"Rattus norvegicus killer cell lectin-like receptor subfamily C, member 2 (Klrc2), mRNA","Q9MZJ3",164,{"v":1e-45,"d":"1.00E-45"},"NKG2-A/NKG2-B type II integral membrane protein",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0002223|stimulatory C-type lectin receptor signaling pathway;GO:0002228|natural killer cell mediated immunity;GO:0008150|biological_process;GO:0043323|positive regulation of natural killer cell degranulation;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;","GO:0005575|cellular_component;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0043235|receptor complex;","GO:0003674|molecular_function;GO:0023024|MHC class I protein complex binding;GO:1990405|protein antigen binding;",".","."]
["ENSRNOG00000000335",18,1.494479889,3,0.192991315,7.743767604,2.953035657,{"v":8.16559e-05,"d":"8.17E-05"},{"v":9.66524e-05,"d":"9.67E-05"},"up","yes","Ermap","protein_coding","chr5:132789991-132802847:-","gi|672019865|ref|XP_008774301.1|",2758,0,"PREDICTED: erythroid membrane-associated protein isoform X5 [Rattus norvegicus]","gi|672019864|ref|XM_008776079.1|",2019,0,"PREDICTED: Rattus norvegicus erythroblast membrane-associated protein (Ermap), transcript variant X12, mRNA","Q9JLN5",926,0,"Erythroid membrane-associated protein",".",".",".",".","pfam13765","PRY","SPRY-associated domain. SPRY and PRY domains occur on PYRIN proteins. Their function is not known.","GO:0001817|regulation of cytokine production;GO:0050852|T cell receptor signaling pathway;","GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0031410|cytoplasmic vesicle;","GO:0005102|signaling receptor binding;","K06712","BTN, CD277; butyrophilin"]
["ENSRNOG00000025640",18,1.494479889,3,0.192991315,7.743767604,2.953035657,{"v":8.16559e-05,"d":"8.17E-05"},{"v":9.66524e-05,"d":"9.67E-05"},"up","yes","ENSRNOG00000025640","protein_coding","chr15:24291243-24295559:-","gi|564385934|ref|XP_006251931.1|",1843,0,"PREDICTED: olfactory receptor Olr1637 isoform X1 [Rattus norvegicus]","gi|672077519|ref|XM_006251869.2|",1348,0,"PREDICTED: Rattus norvegicus olfactory receptor 1637 (Olr1637), transcript variant X1, mRNA","Q8NH40",556,0,"Olfactory receptor 6S1",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0050911|detection of chemical stimulus involved in sensory perception of smell;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004984|olfactory receptor activity;","K04257","OLFR; olfactory receptor"]
["ENSRNOG00000059476",18,1.494479889,3,0.192991315,7.743767604,2.953035657,{"v":8.16559e-05,"d":"8.17E-05"},{"v":9.66524e-05,"d":"9.67E-05"},"up","yes","AABR07049503.1","lncRNA","chr5:120006310-120012574:-",".",".",".",".","gi|672053374|ref|XR_592669.1|",858,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102549668 (LOC102549668), transcript variant X2, ncRNA",".",".",".",".",".",".",".",".","pfam00101","RuBisCO_small","Ribulose bisphosphate carboxylase, small chain.",".",".",".",".","."]
["ENSRNOG00000033520",48,3.985279705,24,1.543930516,2.581255868,1.368073156,{"v":8.76924e-05,"d":"8.77E-05"},1.03319E-4,"up","yes","Wdr97","protein_coding","chr7:108078337-108087034:+","gi|564308945|ref|XP_006226201.1|",7611,0,"PREDICTED: WD repeat-containing protein KIAA1875-like isoform X1 [Rattus norvegicus]","gi|672022059|ref|XM_006226139.2|",5151,0,"PREDICTED: Rattus norvegicus similar to KIAA1875 protein (RGD1562063), transcript variant X1, mRNA","A6NE52",1496,0,"WD repeat-containing protein 97",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.",".",".",".",".","."]
["ENSRNOG00000004752",35,2.905933118,14,0.900626135,3.226569835,1.690001251,{"v":9.11598e-05,"d":"9.12E-05"},1.0705E-4,"up","yes","Nalcn","protein_coding","chr15:100398615-100741001:-","gi|755548470|ref|XP_011243398.1|",8774,0,"PREDICTED: sodium leak channel non-selective protein isoform X4 [Mus musculus]","gi|24025649|ref|NM_153630.1|",6737,0,"Rattus norvegicus sodium leak channel, non-selective (Nalcn), mRNA","Q6Q760",3348,0,"Sodium leak channel non-selective protein",".",".",".",".","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0008150|biological_process;GO:0034765|regulation of ion transmembrane transport;GO:0035725|sodium ion transmembrane transport;GO:0060075|regulation of resting membrane potential;GO:0070588|calcium ion transmembrane transport;GO:0071805|potassium ion transmembrane transport;GO:0098655|cation transmembrane transport;","GO:0005575|cellular_component;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0005244|voltage-gated ion channel activity;GO:0005261|cation channel activity;GO:0005272|sodium channel activity;GO:0022840|leak channel activity;","K21863","NALCN; sodium leak channel non-selective protein"]
["ENSRNOG00000042367",49,4.068306366,25,1.608260955,2.529630751,1.338926811,{"v":9.69112e-05,"d":"9.69E-05"},1.13346E-4,"up","yes","Cyp2ab1","protein_coding","chr11:80582938-80590873:+","gi|149019842|gb|EDL77990.1|",2438,0,"rCG36686, isoform CRA_a [Rattus norvegicus]","gi|672026287|ref|XM_008758212.1|",1463,0,"PREDICTED: Rattus norvegicus cytochrome P450, family 2, subfamily ab, polypeptide 1 (Cyp2ab1), mRNA","O54749",349,{"v":5E-110,"d":"5.00E-110"},"Cytochrome P450 2J5","alr1450",100,{"v":9e-22,"d":"9.00E-22"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0006082|organic acid metabolic process;GO:0006805|xenobiotic metabolic process;GO:0042178|xenobiotic catabolic process;","GO:0005737|cytoplasm;GO:0016020|membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0005506|iron ion binding;GO:0008395|steroid hydroxylase activity;GO:0016712|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0020037|heme binding;",".","."]
["ENSRNOG00000031443",23,1.909613192,6,0.385982629,4.94740708,2.306672612,{"v":9.99531e-05,"d":"1.00E-04"},1.1669E-4,"up","yes","Havcr2","protein_coding","chr10:30882606-30909137:+","gi|158508553|ref|NP_001094232.1|",1067,{"v":9e-135,"d":"9.00E-135"},"hepatitis A virus cellular receptor 2 homolog precursor [Rattus norvegicus]","gi|158508552|ref|NM_001100762.1|",2763,0,"Rattus norvegicus hepatitis A virus cellular receptor 2 (Havcr2), mRNA","P0C0K5",415,{"v":3e-136,"d":"3.00E-136"},"Hepatitis A virus cellular receptor 2 homolog",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0001819|positive regulation of cytokine production;GO:0002250|adaptive immune response;GO:0002281|macrophage activation involved in immune response;GO:0002519|natural killer cell tolerance induction;GO:0002652|regulation of tolerance induction dependent upon immune response;GO:0002826|negative regulation of T-helper 1 type immune response;GO:0002838|negative regulation of immune response to tumor cell;GO:0002859|negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target;GO:0006954|inflammatory response;GO:0008150|biological_process;GO:0010629|negative regulation of gene expression;GO:0030886|negative regulation of myeloid dendritic cell activation;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0032480|negative regulation of type I interferon production;GO:0032687|negative regulation of interferon-alpha production;GO:0032689|negative regulation of interferon-gamma production;GO:0032703|negative regulation of interleukin-2 production;GO:0032712|negative regulation of interleukin-3 production;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032722|positive regulation of chemokine production;GO:0032729|positive regulation of interferon-gamma production;GO:0032732|positive regulation of interleukin-1 production;GO:0032753|positive regulation of interleukin-4 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032815|negative regulation of natural killer cell activation;GO:0034138|toll-like receptor 3 signaling pathway;GO:0034154|toll-like receptor 7 signaling pathway;GO:0034162|toll-like receptor 9 signaling pathway;GO:0042102|positive regulation of T cell proliferation;GO:0042130|negative regulation of T cell proliferation;GO:0043032|positive regulation of macrophage activation;GO:0045087|innate immune response;GO:0045089|positive regulation of innate immune response;GO:0045824|negative regulation of innate immune response;GO:0050830|defense response to Gram-positive bacterium;GO:0060135|maternal process involved in female pregnancy;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071222|cellular response to lipopolysaccharide;GO:0071656|negative regulation of granulocyte colony-stimulating factor production;GO:1900425|negative regulation of defense response to bacterium;GO:1900426|positive regulation of defense response to bacterium;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:2000521|negative regulation of immunological synapse formation;GO:2001189|negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;","GO:0001772|immunological synapse;GO:0005769|early endosome;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0030054|cell junction;","GO:0003674|molecular_function;GO:0046872|metal ion binding;","K20414","HAVCR2, CD366; hepatitis A virus cellular receptor 2"]
["ENSRNOG00000004003",32,2.656853137,12,0.771965258,3.441674491,1.783110655,1.02545E-4,1.19498E-4,"up","yes","Dusp10","protein_coding","chr13:95614292-95651716:+","gi|157787135|ref|NP_001099204.1|",2289,0,"dual specificity protein phosphatase 10 [Rattus norvegicus]","gi|157787134|ref|NM_001105734.1|",2701,0,"Rattus norvegicus dual specificity phosphatase 10 (Dusp10), mRNA","Q9ESS0",868,0,"Dual specificity protein phosphatase 10","YNL053w",69.7,{"v":2e-11,"d":"2.00E-11"},"COG2453","pfam00782","DSPc","Dual specificity phosphatase, catalytic domain. Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a \"recognition\" region.","GO:0002819|regulation of adaptive immune response;GO:0006470|protein dephosphorylation;GO:0010033|response to organic substance;GO:0010633|negative regulation of epithelial cell migration;GO:0016311|dephosphorylation;GO:0032496|response to lipopolysaccharide;GO:0032873|negative regulation of stress-activated MAPK cascade;GO:0035970|peptidyl-threonine dephosphorylation;GO:0043409|negative regulation of MAPK cascade;GO:0043508|negative regulation of JUN kinase activity;GO:0044387|negative regulation of protein kinase activity by regulation of protein phosphorylation;GO:0045088|regulation of innate immune response;GO:0045591|positive regulation of regulatory T cell differentiation;GO:0046329|negative regulation of JNK cascade;GO:0048709|oligodendrocyte differentiation;GO:0048715|negative regulation of oligodendrocyte differentiation;GO:0050680|negative regulation of epithelial cell proliferation;GO:0060266|negative regulation of respiratory burst involved in inflammatory response;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0090335|regulation of brown fat cell differentiation;GO:1903753|negative regulation of p38MAPK cascade;GO:1905042|negative regulation of epithelium regeneration;GO:1990264|peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0016607|nuclear speck;","GO:0003674|molecular_function;GO:0004721|phosphoprotein phosphatase activity;GO:0004725|protein tyrosine phosphatase activity;GO:0008330|protein tyrosine/threonine phosphatase activity;GO:0008432|JUN kinase binding;GO:0016791|phosphatase activity;GO:0017017|MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0033549|MAP kinase phosphatase activity;GO:0048273|mitogen-activated protein kinase p38 binding;","K20216","DUSP10; dual specificity phosphatase 10 [EC:3.1.3.16 3.1.3.48]"]
["ENSRNOG00000065945",32,2.656853137,12,0.771965258,3.441674491,1.783110655,1.02545E-4,1.19498E-4,"up","yes","ENSRNOG00000065945","lncRNA","chr5:160567024-160568342:-",".",".",".",".","gi|354795025|gb|JN959526.1|",327,{"v":5e-169,"d":"5.00E-169"},"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Gpr157:tm1e(KOMP)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSRNOG00000037100",50,4.151333026,26,1.672591393,2.481976796,1.311489628,0.000106422,0.000123654,"up","yes","Heatr9","protein_coding","chr10:68308579-68319376:-","gi|564313077|ref|XP_006220813.1|",2934,0,"PREDICTED: protein HEATR9 isoform X1 [Rattus norvegicus]","gi|672025031|ref|XM_006220751.2|",2435,0,"PREDICTED: Rattus norvegicus HEAT repeat containing 9 (Heatr9), transcript variant X1, mRNA","Q5QNV8",890,0,"Protein HEATR9",".",".",".",".","pfam13646","HEAT_2","HEAT repeats. This family includes multiple HEAT repeats.","GO:0002244|hematopoietic progenitor cell differentiation;",".",".",".","."]
["ENSRNOG00000022859",36,2.988959779,15,0.964956573,3.097507041,1.631107562,1.09063E-4,0.000126402,"up","yes","Trem1","protein_coding","chr9:12763819-12779203:-","gi|564367096|ref|XP_006244488.1|",997,{"v":8e-133,"d":"8.00E-133"},"PREDICTED: triggering receptor expressed on myeloid cells 1 isoform X1 [Rattus norvegicus]","gi|672064258|ref|XM_006244426.2|",992,0,"PREDICTED: Rattus norvegicus triggering receptor expressed on myeloid cells 1 (Trem1), transcript variant X1, mRNA","Q9JKE2",304,{"v":3e-101,"d":"3.00E-101"},"Triggering receptor expressed on myeloid cells 1",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0001954|positive regulation of cell-matrix adhesion;GO:0002367|cytokine production involved in immune response;GO:0002526|acute inflammatory response;GO:0010666|positive regulation of cardiac muscle cell apoptotic process;GO:0010759|positive regulation of macrophage chemotaxis;GO:0016477|cell migration;GO:0030593|neutrophil chemotaxis;GO:0032602|chemokine production;GO:0045087|innate immune response;GO:0070945|neutrophil mediated killing of gram-negative bacterium;GO:0071222|cellular response to lipopolysaccharide;GO:0071305|cellular response to vitamin D;GO:0072672|neutrophil extravasation;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0038023|signaling receptor activity;GO:0097110|scaffold protein binding;","K14362","TREM1, CD354; triggering receptor expressed on myeloid cells 1"]
["ENSRNOG00000063575",36,2.988959779,15,0.964956573,3.097507041,1.631107562,1.09063E-4,0.000126402,"up","yes","ENSRNOG00000063575","protein_coding","chr18:71243208-71245690:+","gi|12853880|dbj|BAB29875.1|",272,{"v":2e-24,"d":"2.00E-24"},"unnamed protein product [Mus musculus]","gi|244790128|ref|NR_027978.1|",336,{"v":1E-173,"d":"1.00E-173"},"Mus musculus RIKEN cDNA 4930465K10 gene (4930465K10Rik), long non-coding RNA",".",".",".",".",".",".",".",".","pfam06075","DUF936","Plant protein of unknown function (DUF936). This family consists of several hypothetical proteins from Arabidopsis thaliana and Oryza sativa. The function of this family is unknown.",".",".",".",".","."]
["ENSRNOG00000017412",26,2.158693174,8,0.514643505,4.194540785,2.068512874,1.10696E-4,1.28155E-4,"up","yes","AABR07001512.1","protein_coding","chr1:48369044-48369595:-","gi|94400930|ref|NP_001035361.1|",581,{"v":6e-74,"d":"6.00E-74"},"deoxyuridine 5'-triphosphate nucleotidohydrolase isoform 2 [Rattus norvegicus]","gi|346227228|ref|NG_027937.2|",346,{"v":5e-180,"d":"5.00E-180"},"Rattus norvegicus deoxyuridine triphosphatase pseudogene (Dut-ps) on chromosome 1","P70583",229,{"v":3e-75,"d":"3.00E-75"},"Deoxyuridine 5'-triphosphate nucleotidohydrolase","SPAC644.05c",132,{"v":8e-39,"d":"8.00E-39"},"COG0756","pfam00692","dUTPase","dUTPase. dUTPase hydrolyses dUTP to dUMP and pyrophosphate.",".",".",".",".","."]
["ENSRNOG00000045595",26,2.158693174,8,0.514643505,4.194540785,2.068512874,1.10696E-4,1.28155E-4,"up","yes","Tnfsf9","protein_coding","chr9:1944017-1946345:+","gi|31077104|ref|NP_852049.1|",1569,0,"tumor necrosis factor ligand superfamily member 9 [Rattus norvegicus]","gi|31341223|ref|NM_181384.2|",1301,0,"Rattus norvegicus tumor necrosis factor superfamily member 9 (Tnfsf9), mRNA","P41274",486,{"v":5e-170,"d":"5.00E-170"},"Tumor necrosis factor ligand superfamily member 9",".",".",".",".","pfam00229","TNF","TNF(tumor Necrosis Factor) family.","GO:0006955|immune response;GO:0007165|signal transduction;GO:0032729|positive regulation of interferon-gamma production;GO:0032735|positive regulation of interleukin-12 production;GO:0032755|positive regulation of interleukin-6 production;GO:0042104|positive regulation of activated T cell proliferation;GO:0042127|regulation of cell proliferation;GO:0043011|myeloid dendritic cell differentiation;GO:0045585|positive regulation of cytotoxic T cell differentiation;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0005102|signaling receptor binding;GO:0005125|cytokine activity;GO:0005164|tumor necrosis factor receptor binding;GO:0032813|tumor necrosis factor receptor superfamily binding;","K05472","TNFSF9, CD137L; tumor necrosis factor ligand superfamily member 9"]
["ENSRNOG00000048161",26,2.158693174,8,0.514643505,4.194540785,2.068512874,1.10696E-4,1.28155E-4,"up","yes","Tlr9","protein_coding","chr8:106864680-106868796:+","gi|149018685|gb|EDL77326.1|",5007,0,"toll-like receptor 9 [Rattus norvegicus]","gi|37693511|ref|NM_198131.1|",3267,0,"Rattus norvegicus toll-like receptor 9 (Tlr9), mRNA","Q9EQU3",1627,0,"Toll-like receptor 9","alr0124_1",68.6,{"v":5e-11,"d":"5.00E-11"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0001774|microglial cell activation;GO:0001819|positive regulation of cytokine production;GO:0001932|regulation of protein phosphorylation;GO:0002218|activation of innate immune response;GO:0002224|toll-like receptor signaling pathway;GO:0002639|positive regulation of immunoglobulin production;GO:0002730|regulation of dendritic cell cytokine production;GO:0002755|MyD88-dependent toll-like receptor signaling pathway;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0007252|I-kappaB phosphorylation;GO:0008584|male gonad development;GO:0009615|response to virus;GO:0010508|positive regulation of autophagy;GO:0010628|positive regulation of gene expression;GO:0030277|maintenance of gastrointestinal epithelium;GO:0030890|positive regulation of B cell proliferation;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0032715|negative regulation of interleukin-6 production;GO:0032717|negative regulation of interleukin-8 production;GO:0032722|positive regulation of chemokine production;GO:0032725|positive regulation of granulocyte macrophage colony-stimulating factor production;GO:0032727|positive regulation of interferon-alpha production;GO:0032728|positive regulation of interferon-beta production;GO:0032729|positive regulation of interferon-gamma production;GO:0032733|positive regulation of interleukin-10 production;GO:0032735|positive regulation of interleukin-12 production;GO:0032741|positive regulation of interleukin-18 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0034122|negative regulation of toll-like receptor signaling pathway;GO:0034123|positive regulation of toll-like receptor signaling pathway;GO:0034162|toll-like receptor 9 signaling pathway;GO:0034163|regulation of toll-like receptor 9 signaling pathway;GO:0034165|positive regulation of toll-like receptor 9 signaling pathway;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043410|positive regulation of MAPK cascade;GO:0043507|positive regulation of JUN kinase activity;GO:0045087|innate immune response;GO:0045577|regulation of B cell differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050727|regulation of inflammatory response;GO:0050729|positive regulation of inflammatory response;GO:0050829|defense response to Gram-negative bacterium;GO:0050864|regulation of B cell activation;GO:0050871|positive regulation of B cell activation;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051607|defense response to virus;GO:0051770|positive regulation of nitric-oxide synthase biosynthetic process;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0071222|cellular response to lipopolysaccharide;GO:0071248|cellular response to metal ion;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1901895|negative regulation of calcium-transporting ATPase activity;GO:1902350|cellular response to chloroquine;","GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0005768|endosome;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0032009|early phagosome;GO:0036019|endolysosome;GO:0045335|phagocytic vesicle;","GO:0003953|NAD+ nucleosidase activity;GO:0004888|transmembrane signaling receptor activity;GO:0005149|interleukin-1 receptor binding;GO:0035197|siRNA binding;GO:0038187|pattern recognition receptor activity;GO:0045322|unmethylated CpG binding;","K10161","TLR9, CD289; toll-like receptor 9"]
["ENSRNOG00000009117",66,5.479759595,40,2.573217527,2.129536091,1.090539181,1.19602E-4,1.37718E-4,"up","yes","Otub2","protein_coding","chr6:122545061-122563644:+","gi|564357037|ref|XP_006240539.1|",1811,0,"PREDICTED: ubiquitin thioesterase OTUB2 isoform X1 [Rattus norvegicus]","gi|672056640|ref|XM_006240477.2|",3082,0,"PREDICTED: Rattus norvegicus OTU deubiquitinase, ubiquitin aldehyde binding 2 (Otub2), transcript variant X1, mRNA","Q9CQX0",478,{"v":8e-160,"d":"8.00E-160"},"Ubiquitin thioesterase OTUB2","ECU05g0570",57.4,3e-08,"COG5539","pfam10275","Peptidase_C65","Peptidase C65 Otubain. This family of proteins conserved from plants to humans is a highly specific ubiquitin iso-peptidase that removes ubiquitin from proteins. The modification of cellular proteins by ubiquitin (Ub) is an important event that underlies protein stability and function in eukaryote being a dynamic and reversible process. Otubain carries several key conserved domains: (i) the OTU (ovarian tumor domain) in which there is an active cysteine protease triad (ii) a nuclear localisation signal, (iii) a Ub interaction motif (UIM)-like motif phi-xx-A-xxxs-xx-Ac (where phi indicates an aromatic amino acid, x indicates any amino acid and Ac indicates an acidic amino acid), (iv) a Ub-associated (UBA)-like domain and (v) the LxxLL motif.","GO:0016579|protein deubiquitination;GO:0035871|protein K11-linked deubiquitination;GO:0070536|protein K63-linked deubiquitination;GO:0071108|protein K48-linked deubiquitination;GO:1901315|negative regulation of histone H2A K63-linked ubiquitination;GO:2000780|negative regulation of double-strand break repair;","GO:0005634|nucleus;","GO:0004843|thiol-dependent ubiquitin-specific protease activity;GO:0043130|ubiquitin binding;","K09603","OTUB2; ubiquitin thioesterase protein OTUB2 [EC:3.4.19.12]"]
["ENSRNOG00000018949",21,1.743559871,5,0.321652191,5.420637323,2.438462484,0.00012235,1.40679E-4,"up","yes","Dlk2","protein_coding","chr9:14676562-14681594:-","gi|672064328|ref|XP_008765087.1|",1869,0,"PREDICTED: protein delta homolog 2 isoform X2 [Rattus norvegicus]","gi|672064327|ref|XM_008766865.1|",1664,0,"PREDICTED: Rattus norvegicus delta-like 2 homolog (Drosophila) (Dlk2), transcript variant X2, mRNA","D3ZUK3",672,0,"Protein delta homolog 2",".",".",".",".","pfam00008","EGF","EGF-like domain. There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.","GO:0045598|regulation of fat cell differentiation;GO:0045746|negative regulation of Notch signaling pathway;","GO:0016021|integral component of membrane;","GO:0005112|Notch binding;GO:0005509|calcium ion binding;GO:0042802|identical protein binding;","K24462","DLK2, EGFL9; protein delta homolog 2"]
["ENSRNOG00000037251",60,4.981599631,35,2.251565336,2.21250503,1.145680735,0.000135231,0.000154407,"up","yes","Zfp248","protein_coding","chr4:151606495-151629850:-","gi|564304274|ref|XP_006225094.1|",3084,0,"PREDICTED: zinc finger protein 248 isoform X1 [Rattus norvegicus]","gi|672018677|ref|XM_006225032.2|",2362,0,"PREDICTED: Rattus norvegicus zinc finger protein 248 (Zfp248), transcript variant X1, mRNA","Q8NDW4",890,0,"Zinc finger protein 248",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;",".","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0046872|metal ion binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSRNOG00000010111",47,3.902253045,24,1.543930516,2.527479704,1.337699507,1.36114E-4,0.000155288,"up","yes","Exoc3l4","protein_coding","chr6:130452661-130466683:+","gi|564357330|ref|XP_006240634.1|",3424,0,"PREDICTED: exocyst complex component 3-like protein 4 isoform X2 [Rattus norvegicus]","gi|298889985|emb|FQ230530.1|",3263,0,"Rattus norvegicus TL0AEA92YE13 mRNA sequence","Q6DIA2",1217,0,"Exocyst complex component 3-like protein 4",".",".",".",".","pfam06046","Sec6","Exocyst complex component Sec6. Sec6 is a component of the multiprotein exocyst complex. Sec6 interacts with Sec8, Sec10 and Exo70.These exocyst proteins localize to regions of active exocytosis-at the growing ends of interphase cells and in the medial region of cells undergoing cytokinesis-in an F-actin-dependent and exocytosis- independent manner.","GO:0006887|exocytosis;GO:0051601|exocyst localization;","GO:0000145|exocyst;","GO:0000149|SNARE binding;",".","."]
["ENSRNOG00000063400",47,3.902253045,24,1.543930516,2.527479704,1.337699507,1.36114E-4,0.000155288,"up","yes","Shisa9","protein_coding","chr10:3337979-3627773:-","gi|589942480|ref|XP_006983953.1|",1949,0,"PREDICTED: protein shisa-9 isoform X1 [Peromyscus maniculatus bairdii]","gi|672066485|ref|XM_008767465.1|",1854,0,"PREDICTED: Rattus norvegicus shisa family member 9 (Shisa9), transcript variant X3, mRNA","Q9CZN4",753,0,"Protein shisa-9",".",".",".",".","pfam13908","Shisa","Wnt and FGF inhibitory regulator. Shisa is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface.",".",".",".",".","."]
["ENSRNOG00000002013",12,0.996319926,0,0.032165219,30.97507041,4.953035657,0.000136245,0.000155288,"up","yes","Sidt1","protein_coding","chr11:56363512-56459050:+","gi|281306752|ref|NP_001094123.1|",3592,0,"SID1 transmembrane family member 1 precursor [Rattus norvegicus]","gi|281306751|ref|NM_001100653.1|",3495,0,"Rattus norvegicus SID1 transmembrane family, member 1 (Sidt1), mRNA","Q6Q3F5",1388,0,"SID1 transmembrane family member 1",".",".",".",".","pfam13965","SID-1_RNA_chan","dsRNA-gated channel SID-1. This is a family of proteins that are transmembrane dsRNA-gated channels. They passively transport dsRNA into cells and do not act as ATP-dependent pumps. They are required for systemic RNA interference.","GO:0050658|RNA transport;","GO:0005764|lysosome;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0003725|double-stranded RNA binding;GO:0015485|cholesterol binding;GO:0051033|RNA transmembrane transporter activity;",".","."]
["ENSRNOG00000010880",12,0.996319926,0,0.032165219,30.97507041,4.953035657,0.000136245,0.000155288,"up","yes","Gpr27","protein_coding","chr4:132328364-132329497:+","gi|12831217|ref|NP_075587.1|",1145,{"v":4e-152,"d":"4.00E-152"},"probable G-protein coupled receptor 27 [Rattus norvegicus]","gi|12831216|ref|NM_023099.1|",1128,0,"Rattus norvegicus G protein-coupled receptor 27 (Gpr27), mRNA","Q9JJH3",445,{"v":1E-153,"d":"1.00E-153"},"Probable G-protein coupled receptor 27",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0035774|positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:1900738|positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;","K04301","SREB1, GPR27; super conserved receptor expressed in brain 1"]
["ENSRNOG00000015159",12,0.996319926,0,0.032165219,30.97507041,4.953035657,0.000136245,0.000155288,"up","yes","Slc9a3","protein_coding","chr1:29124674-29167417:-","gi|672034078|ref|XP_008756899.1|",4109,0,"PREDICTED: sodium/hydrogen exchanger 3 isoform X1 [Rattus norvegicus]","gi|6981561|ref|NM_012654.1|",5110,0,"Rattus norvegicus solute carrier family 9 member A3 (Slc9a3), mRNA","P26433",1585,0,"Sodium/hydrogen exchanger 3","SPAC15A10.06",140,{"v":1e-33,"d":"1.00E-33"},"COG0025","pfam00999","Na_H_Exchanger","Sodium/hydrogen exchanger family. Na/H antiporters are key transporters in maintaining the pH of actively metabolizing cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.","GO:0002028|regulation of sodium ion transport;GO:0006814|sodium ion transport;GO:0006885|regulation of pH;GO:0006898|receptor-mediated endocytosis;GO:0007623|circadian rhythm;GO:0051384|response to glucocorticoid;GO:0051453|regulation of intracellular pH;GO:0071805|potassium ion transmembrane transport;GO:0098656|anion transmembrane transport;GO:0098719|sodium ion import across plasma membrane;GO:1902600|proton transmembrane transport;","GO:0005886|plasma membrane;GO:0005903|brush border;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0031526|brush border membrane;GO:0031982|vesicle;GO:0070062|extracellular exosome;","GO:0005515|protein binding;GO:0015385|sodium:proton antiporter activity;GO:0015386|potassium:proton antiporter activity;GO:0030165|PDZ domain binding;","K12040","SLC9A3, NHE3; solute carrier family 9 (sodium/hydrogen exchanger), member 3"]
["ENSRNOG00000032247",12,0.996319926,0,0.032165219,30.97507041,4.953035657,0.000136245,0.000155288,"up","yes","Bank1","protein_coding","chr2:224530475-224800405:-","gi|306482656|ref|NP_001041383.2|",3738,0,"B-cell scaffold protein with ankyrin repeats [Rattus norvegicus]","gi|306482655|ref|NM_001047918.2|",3106,0,"Rattus norvegicus B-cell scaffold protein with ankyrin repeats 1 (Bank1), mRNA","Q80VH0",1208,0,"B-cell scaffold protein with ankyrin repeats",".",".",".",".","pfam14545","DBB","Dof, BCAP, and BANK (DBB) motif,. The DBB domain is named from the Drosophila (Downstream of FGFR - Dof, also known as Heartbroken or Stumps) protein, the BANKS and BCAP, both signalling in B-cell pathway, proteins. This domain defines a minimal region required for mediating Dof dimerization. Since this domain can interact both with itself and with a region in the C-terminal part of the molecule, it may mediate either intermolecular or intramolecular interactions. Mutants lacking this domain disrupt FGFR signal transduction and fibroblast growth-factor signalling.","GO:0007165|signal transduction;GO:0008150|biological_process;GO:0009617|response to bacterium;GO:0032715|negative regulation of interleukin-6 production;GO:0042113|B cell activation;GO:0043410|positive regulation of MAPK cascade;GO:0045947|negative regulation of translational initiation;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050869|negative regulation of B cell activation;GO:0051898|negative regulation of protein kinase B signaling;","GO:0005575|cellular_component;GO:0048471|perinuclear region of cytoplasm;","GO:0002020|protease binding;GO:0003674|molecular_function;GO:0003953|NAD+ nucleosidase activity;GO:0005102|signaling receptor binding;GO:0035591|signaling adaptor activity;GO:0043274|phospholipase binding;GO:1990782|protein tyrosine kinase binding;",".","."]
["ENSRNOG00000033109",12,0.996319926,0,0.032165219,30.97507041,4.953035657,0.000136245,0.000155288,"up","yes","AC097037.1","protein_coding","chr15:27589114-27589647:-","gi|149063834|gb|EDM14104.1|",543,{"v":1e-68,"d":"1.00E-68"},"rCG23496, partial [Rattus norvegicus]","gi|218511252|gb|AC097037.8|",402,0,"Rattus norvegicus CH230-20D8 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","A0A0B4J264",68.2,{"v":9e-14,"d":"9.00E-14"},"T cell receptor alpha variable 38-1",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000062742",12,0.996319926,0,0.032165219,30.97507041,4.953035657,0.000136245,0.000155288,"up","yes","ENSRNOG00000062742","lncRNA","chr12:15884585-15894265:+",".",".",".",".","gi|755514887|ref|XM_006504775.2|",483,0,"PREDICTED: Mus musculus family with sequence similarity 20, member C (Fam20c), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam15373","DUF4601","Domain of unknown function (DUF4601). This protein family is a domain of unknown function, which is found in eukaryotes. In humans, the gene encoding this protein is found in the position, chromosome 19 open reading frame 45.",".",".",".",".","."]
["ENSRNOG00000068415",12,0.996319926,0,0.032165219,30.97507041,4.953035657,0.000136245,0.000155288,"up","yes","Lrrc15","protein_coding","chr11:70469804-70484267:+","gi|564377191|ref|XP_006248544.1|",2584,0,"PREDICTED: leucine-rich repeat-containing protein 15 isoform X1 [Rattus norvegicus]","gi|672071373|ref|XM_006248482.2|",2068,0,"PREDICTED: Rattus norvegicus leucine rich repeat containing 15 (Lrrc15), transcript variant X1, mRNA","Q8R5M3",994,0,"Leucine-rich repeat-containing protein 15","alr0124_1",88.6,{"v":4e-17,"d":"4.00E-17"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.",".",".",".",".","."]
["ENSRNOG00000007012",53,4.400413008,29,1.865582707,2.35873381,1.238012616,0.000136318,1.55344E-4,"up","yes","Ly75","protein_coding","chr3:44765122-44852374:-","gi|564301698|ref|XP_006224510.1|",9264,0,"PREDICTED: lymphocyte antigen 75 [Rattus norvegicus]","gi|672045718|ref|XM_006234242.2|",6498,0,"PREDICTED: Rattus norvegicus lymphocyte antigen 75 (Ly75), mRNA","Q60767",3208,0,"Lymphocyte antigen 75",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0006897|endocytosis;","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0030246|carbohydrate binding;GO:0038023|signaling receptor activity;","K06559","LY75, CD205; lymphocyte antigen 75"]
["ENSRNOG00000068238",30,2.490799816,11,0.70763482,3.519894365,1.815532133,1.40054E-4,1.59147E-4,"up","yes","ENSRNOG00000068238","lncRNA","chr4:59724069-59807655:-","gi|148708927|gb|EDL40873.1|",146,5e-07,"mCG1043924, partial [Mus musculus]","gi|672018242|ref|XM_008775716.1|",3158,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103692111 (LOC103692111), mRNA",".",".",".",".",".",".",".",".","pfam04093","MreD","rod shape-determining protein MreD. MreD (murein formation D) is involved in the rod shape determination in Escherichia coli, and more generally in cell shape determination of bacteria whether or not they are rod-shaped.",".",".",".",".","."]
["ENSRNOG00000071112",30,2.490799816,11,0.70763482,3.519894365,1.815532133,1.40054E-4,1.59147E-4,"up","yes","ENSRNOG00000071112","lncRNA","chr10:88074662-88076733:+","gi|149025935|gb|EDL82178.1|",137,9e-07,"rCG28938 [Rattus norvegicus]","gi|672069529|ref|XM_006247518.2|",2072,0,"PREDICTED: Rattus norvegicus hexamethylene bis-acetamide inducible 2 (Hexim2), transcript variant X10, mRNA",".",".",".",".",".",".",".",".","pfam03638","TCR","Tesmin/TSO1-like CXC domain, cysteine-rich domain. This family includes proteins that have two copies of a cysteine rich motif as follows: C-X-C-X4-C-X3-YC-X-C-X6-C-X3-C-X-C-X2-C. The family includes Tesmin and TSO1. This family is called a CXC domain in.",".",".",".",".","."]
["ENSRNOG00000016275",13,1.079346587,1,0.064330438,16.77816314,4.068512874,0.000143624,0.000162828,"up","yes","Ttr","protein_coding","chr18:11943789-11951008:+","gi|333033763|ref|NP_036813.2|",755,{"v":7e-99,"d":"7.00E-99"},"transthyretin precursor [Rattus norvegicus]","gi|564392776|ref|XM_006254457.1|",676,0,"PREDICTED: Rattus norvegicus transthyretin (Ttr), transcript variant X1, mRNA","P02767",295,{"v":2E-100,"d":"2.00E-100"},"Transthyretin","Cj0715",60.8,{"v":4e-11,"d":"4.00E-11"},"COG2351","pfam00576","Transthyretin","HIUase/Transthyretin family. This family includes transthyretin that is a thyroid hormone-binding protein that transports thyroxine from the bloodstream to the brain. However, most of the sequences listed in this family do not bind thyroid hormones. They are actually enzymes of the purine catabolism that catalyse the conversion of 5-hydroxyisourate (HIU) to OHCU. HIU hydrolysis is the original function of the family and is conserved from bacteria to mammals; transthyretins arose by gene duplications in the vertebrate lineage. HIUases are distinguished in the alignment from the conserved C-terminal YRGS sequence.","GO:0006144|purine nucleobase metabolic process;GO:0007165|signal transduction;GO:0042403|thyroid hormone metabolic process;GO:0042572|retinol metabolic process;GO:0070327|thyroid hormone transport;","GO:0005615|extracellular space;GO:0032991|protein-containing complex;","GO:0005179|hormone activity;GO:0036094|small molecule binding;GO:0042562|hormone binding;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;GO:0070324|thyroid hormone binding;","K20731","TTR; transthyretin"]
["ENSRNOG00000036726",13,1.079346587,1,0.064330438,16.77816314,4.068512874,0.000143624,0.000162828,"up","yes","Cd300e","protein_coding","chr10:100291437-100299311:-","gi|262205519|ref|NP_001160049.1|",995,{"v":2e-134,"d":"2.00E-134"},"CMRF35-like molecule 2 precursor [Rattus norvegicus]","gi|672069895|ref|XM_008768395.1|",722,0,"PREDICTED: Rattus norvegicus Cd300e molecule (Cd300e), transcript variant X2, mRNA","Q8K249",266,{"v":4e-88,"d":"4.00E-88"},"CMRF35-like molecule 2",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004888|transmembrane signaling receptor activity;","K06719","CD300; CD300 antigen"]
["ENSRNOG00000068082",13,1.079346587,1,0.064330438,16.77816314,4.068512874,0.000143624,0.000162828,"up","yes","ENSRNOG00000068082","protein_coding","chr15:29915483-29918511:-","gi|392333295|ref|XP_003752852.1|",1256,{"v":3e-172,"d":"3.00E-172"},"PREDICTED: mast cell protease 8-like [Rattus norvegicus]","gi|672028513|ref|XM_003752804.3|",774,0,"PREDICTED: Rattus norvegicus mast cell protease 8-like (LOC100912724), mRNA","P97594",448,{"v":6E-158,"d":"6.00E-158"},"Mast cell protease 8","VC1200",85.5,{"v":5e-18,"d":"5.00E-18"},"COG5640","pfam00089","Trypsin","Trypsin.",".",".",".",".","."]
["ENSRNOG00000019203",24,1.992639853,7,0.450313067,4.425010059,2.145680735,1.43771E-4,0.000162937,"up","yes","Eya2","protein_coding","chr3:154335400-154518793:+","gi|672047942|ref|XP_008760678.1|",2672,0,"PREDICTED: eyes absent homolog 2 isoform X1 [Rattus norvegicus]","gi|672047941|ref|XM_008762456.1|",2169,0,"PREDICTED: Rattus norvegicus EYA transcriptional coactivator and phosphatase 2 (Eya2), transcript variant X1, mRNA","O08575",1005,0,"Eyes absent homolog 2",".",".",".",".","pfam06912","DUF1275","Protein of unknown function (DUF1275). This family consists of several hypothetical bacterial proteins of around 200 residues in length. The function of this family is unknown although a few members are thought to be membrane proteins.","GO:0006281|DNA repair;GO:0006470|protein dephosphorylation;GO:0014706|striated muscle tissue development;GO:0016576|histone dephosphorylation;GO:0030154|cell differentiation;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0045739|positive regulation of DNA repair;GO:0048856|anatomical structure development;GO:0097192|extrinsic apoptotic signaling pathway in absence of ligand;GO:0097345|mitochondrial outer membrane permeabilization;GO:2001240|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;","GO:0000287|magnesium ion binding;GO:0004725|protein tyrosine phosphatase activity;","K17620","EYA2; eyes absent homolog 2 [EC:3.1.3.48]"]
["ENSRNOG00000029738",19,1.57750655,4,0.257321753,6.130482686,2.61600067,0.000144032,0.000163174,"up","yes","Diras1","protein_coding","chr7:8687942-8693831:+","gi|157823255|ref|NP_001102457.1|",1059,{"v":3E-134,"d":"3.00E-134"},"GTP-binding protein Di-Ras1 [Rattus norvegicus]","gi|157823254|ref|NM_001108987.1|",1897,0,"Rattus norvegicus DIRAS family, GTP-binding RAS-like 1 (Diras1), mRNA","Q91Z61",410,{"v":6e-135,"d":"6.00E-135"},"GTP-binding protein Di-Ras1",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0007165|signal transduction;","GO:0005886|plasma membrane;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0019003|GDP binding;","K07840","DIRAS1; DIRAS family, GTP-binding Ras-like 1"]
["ENSRNOG00000065204",19,1.57750655,4,0.257321753,6.130482686,2.61600067,0.000144032,0.000163174,"up","yes","Fam166b","protein_coding","chr5:57675462-57678611:-","gi|532038518|ref|XP_005362126.1|",1161,{"v":9E-157,"d":"9.00E-157"},"PREDICTED: protein FAM166B isoform X1 [Microtus ochrogaster]","gi|755506548|ref|XM_006538012.2|",747,0,"PREDICTED: Mus musculus family with sequence similarity 166, member B (Fam166b), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam10629","DUF2475","Protein of unknown function (DUF2475). This family of proteins has no known function.",".",".",".",".","."]
["ENSRNOG00000011016",38,3.1550131,17,1.093617449,2.884933029,1.528537828,1.49235E-4,0.00016874,"up","yes","Slc7a2","protein_coding","chr16:51417493-51470784:-","gi|672080252|ref|XP_008769503.1|",3258,0,"PREDICTED: low affinity cationic amino acid transporter 2 isoform X1 [Rattus norvegicus]","gi|402746476|ref|NM_001134686.2|",2482,0,"Rattus norvegicus solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 (Slc7a2), transcript variant 2, mRNA","B5D5N9",1212,0,"Cationic amino acid transporter 2","XF2207",238,{"v":6E-68,"d":"6.00E-68"},"COG0531","pfam13520","AA_permease_2","Amino acid permease.","GO:0002537|nitric oxide production involved in inflammatory response;GO:0006809|nitric oxide biosynthetic process;GO:0006865|amino acid transport;GO:0015807|L-amino acid transport;GO:0015809|arginine transport;GO:0042116|macrophage activation;GO:0043030|regulation of macrophage activation;GO:0050727|regulation of inflammatory response;GO:0089718|amino acid import across plasma membrane;GO:0097638|L-arginine import across plasma membrane;GO:0097639|L-lysine import across plasma membrane;GO:0097640|L-ornithine import across plasma membrane;GO:1902023|L-arginine transport;GO:1902475|L-alpha-amino acid transmembrane transport;GO:1903352|L-ornithine transmembrane transport;GO:1903401|L-lysine transmembrane transport;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030054|cell junction;","GO:0000064|L-ornithine transmembrane transporter activity;GO:0005289|high-affinity arginine transmembrane transporter activity;GO:0005292|high-affinity lysine transmembrane transporter activity;GO:0015171|amino acid transmembrane transporter activity;GO:0015179|L-amino acid transmembrane transporter activity;GO:0015181|arginine transmembrane transporter activity;GO:0015189|L-lysine transmembrane transporter activity;GO:0061459|L-arginine transmembrane transporter activity;GO:0097626|low-affinity L-arginine transmembrane transporter activity;GO:0097627|high-affinity L-ornithine transmembrane transporter activity;","K13864","SLC7A2, ATRC2; solute carrier family 7 (cationic amino acid transporter), member 2"]
["ENSRNOG00000033515",38,3.1550131,17,1.093617449,2.884933029,1.528537828,1.49235E-4,0.00016874,"up","yes","ENSRNOG00000033515","protein_coding","chr13:82172573-82192948:+","gi|295391913|ref|NP_001171301.1|",1898,0,"uncharacterized protein LOC100366054 [Rattus norvegicus]","gi|295391912|ref|NM_001177830.1|",1195,0,"Rattus norvegicus Da1-10-like (LOC100366054), mRNA","Q62904",235,{"v":7E-72,"d":"7.00E-72"},"3-keto-steroid reductase",".",".",".",".","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.",".",".",".",".","."]
["ENSRNOG00000006583",34,2.822906458,14,0.900626135,3.134382125,1.648181075,1.51495E-4,1.71113E-4,"up","yes","Hpgds","protein_coding","chr4:94373342-94397883:-","gi|13928888|ref|NP_113832.1|",1051,{"v":2E-140,"d":"2.00E-140"},"hematopoietic prostaglandin D synthase [Rattus norvegicus]","gi|56799410|ref|NM_031644.2|",1171,0,"Rattus norvegicus hematopoietic prostaglandin D synthase (Hpgds), mRNA","O35543",409,{"v":6e-142,"d":"6.00E-142"},"Hematopoietic prostaglandin D synthase",".",".",".",".","pfam02798","GST_N","Glutathione S-transferase, N-terminal domain. Function: conjugation of reduced glutathione to a variety of targets. Also included in the alignment, but are not GSTs: * S-crystallins from squid. Similarity to GST previously noted. * Eukaryotic elongation factors 1-gamma. Not known to have GST activity; similarity not previously recognized. * HSP26 family of stress-related proteins. including auxin-regulated proteins in plants and stringent starvation proteins in Escherichia coli. Not known to have GST activity. Similarity not previously recognized. The glutathione molecule binds in a cleft between N and C-terminal domains - the catalytically important residues are proposed to reside in the N-terminal domain.","GO:0001516|prostaglandin biosynthetic process;GO:0006693|prostaglandin metabolic process;GO:0006749|glutathione metabolic process;GO:2000255|negative regulation of male germ cell proliferation;","GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0043231|intracellular membrane-bounded organelle;","GO:0000287|magnesium ion binding;GO:0004364|glutathione transferase activity;GO:0004667|prostaglandin-D synthase activity;GO:0005509|calcium ion binding;GO:0042803|protein homodimerization activity;","K04097","HPGDS; prostaglandin-H2 D-isomerase / glutathione transferase [EC:5.3.99.2 2.5.1.18]"]
["ENSRNOG00000065144",73,6.060946218,47,3.023530595,2.004592323,1.003308863,0.000157535,1.77465E-4,"up","yes","ENSRNOG00000065144","lncRNA","chr15:22380903-22382794:+",".",".",".",".","gi|354794928|gb|JN959429.1|",425,0,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Mudeng:tm1a(EUCOMM)Hmgu; transgenic",".",".",".",".",".",".",".",".","pfam14724","mit_SMPDase","Mitochondrial-associated sphingomyelin phosphodiesterase. The GO annotation for this family indicates that it is a single-pass membrane protein, and it appears to be found in mitochondrial membranes. Sphingolipids play important roles in regulating cellular responses, and although mitochondria contain sphingolipids, direct regulation of their levels in mitochondria or mitochondria-associated membranes is mostly unclear. Sphingomyelin phosphodiesterases catalyse the hydrolysis of sphingomyelin to ceramide and phosphocholine, and these metabolites are involved in signalling pathways.",".",".",".",".","."]
["ENSRNOG00000014282",17,1.411453229,3,0.192991315,7.313558292,2.870573497,0.000159914,1.79867E-4,"up","yes","Cebpe","protein_coding","chr15:28169704-28171814:-","gi|74138080|dbj|BAE25437.1|",1465,0,"unnamed protein product [Mus musculus]","gi|625207221|ref|XM_003506128.2|",1107,0,"PREDICTED: Cricetulus griseus CCAAT/enhancer binding protein (C/EBP), epsilon (Cebpe), mRNA","P56261",512,{"v":3e-179,"d":"3.00E-179"},"CCAAT/enhancer-binding protein epsilon",".",".",".",".","pfam07716","bZIP_2","Basic region leucine zipper.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0006909|phagocytosis;GO:0010628|positive regulation of gene expression;GO:0030099|myeloid cell differentiation;GO:0030225|macrophage differentiation;GO:0030851|granulocyte differentiation;GO:0042742|defense response to bacterium;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0071222|cellular response to lipopolysaccharide;","GO:0005575|cellular_component;GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;GO:1990837|sequence-specific double-stranded DNA binding;","K10051","CEBPE; CCAAT/enhancer binding protein (C/EBP), epsilon"]
["ENSRNOG00000016136",17,1.411453229,3,0.192991315,7.313558292,2.870573497,0.000159914,1.79867E-4,"up","yes","Pdcd1lg2","protein_coding","chr1:227158941-227223938:+","gi|255958171|ref|NP_001101052.2|",1344,0,"programmed cell death 1 ligand 2 precursor [Rattus norvegicus]","gi|255958170|ref|NM_001107582.2|",1617,0,"Rattus norvegicus programmed cell death 1 ligand 2 (Pdcd1lg2), mRNA","Q9WUL5",438,{"v":2E-150,"d":"2.00E-150"},"Programmed cell death 1 ligand 2",".",".",".",".","pfam13927","Ig_3","Immunoglobulin domain. This family contains immunoglobulin-like domains.","GO:0006955|immune response;GO:0007166|cell surface receptor signaling pathway;GO:0031295|T cell costimulation;GO:0032689|negative regulation of interferon-gamma production;GO:0032693|negative regulation of interleukin-10 production;GO:0042102|positive regulation of T cell proliferation;GO:0042130|negative regulation of T cell proliferation;GO:0046007|negative regulation of activated T cell proliferation;GO:0071222|cellular response to lipopolysaccharide;","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;",".","K06708","PDCD1LG2, CD273; programmed cell death 1 ligand 2"]
["ENSRNOG00000042289",17,1.411453229,3,0.192991315,7.313558292,2.870573497,0.000159914,1.79867E-4,"up","yes","Plcxd2","protein_coding","chr11:54789477-54853344:+","gi|197333713|ref|NP_001127953.1|",1832,0,"PI-PLC X domain-containing protein 2 [Rattus norvegicus]","gi|197333712|ref|NM_001134481.1|",7359,0,"Rattus norvegicus phosphatidylinositol-specific phospholipase C, X domain containing 2 (Plcxd2), mRNA","B2RXA1",702,0,"PI-PLC X domain-containing protein 2",".",".",".",".","pfam00388","PI-PLC-X","Phosphatidylinositol-specific phospholipase C, X domain. This associates with pfam00387 to form a single structural unit.","GO:0006629|lipid metabolic process;",".","GO:0008081|phosphoric diester hydrolase activity;",".","."]
["ENSRNOG00000043414",17,1.411453229,3,0.192991315,7.313558292,2.870573497,0.000159914,1.79867E-4,"up","yes","Fcrl5","protein_coding","chr2:172881448-172913148:+","gi|672015986|ref|XP_008773409.1|",2880,0,"PREDICTED: Fc receptor-like protein 4 isoform X1 [Rattus norvegicus]","gi|672015985|ref|XM_008775187.1|",1806,0,"PREDICTED: Rattus norvegicus Fc receptor-like 3 (Fcrl3), transcript variant X1, mRNA","Q68SN8",912,0,"Fc receptor-like protein 5",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0050859|negative regulation of B cell receptor signaling pathway;GO:0051280|negative regulation of release of sequestered calcium ion into cytosol;","GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0043235|receptor complex;",".","K06727","FCRL, IRTA, CD307; Fc receptor-like protein"]
["ENSRNOG00000002042",15,1.245399908,2,0.128660876,9.679709505,3.274963752,0.000162014,1.81934E-4,"up","yes","Gfi1","protein_coding","chr14:2042434-2051814:+","gi|390407652|ref|NP_001254550.1|",2118,0,"zinc finger protein Gfi-1 isoform 2 [Mus musculus]","gi|672075407|ref|XM_008769917.1|",2383,0,"PREDICTED: Rattus norvegicus growth factor independent 1 transcription repressor (Gfi1), transcript variant X1, mRNA","Q07120",743,0,"Zinc finger protein Gfi-1",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007638|mechanosensory behavior;GO:0008150|biological_process;GO:0009996|negative regulation of cell fate specification;GO:0010956|negative regulation of calcidiol 1-monooxygenase activity;GO:0010977|negative regulation of neuron projection development;GO:0030097|hemopoiesis;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0034121|regulation of toll-like receptor signaling pathway;GO:0042472|inner ear morphogenesis;GO:0042491|inner ear auditory receptor cell differentiation;GO:0042660|positive regulation of cell fate specification;GO:0045165|cell fate commitment;GO:0045892|negative regulation of transcription, DNA-templated;GO:0051569|regulation of histone H3-K4 methylation;GO:0070105|positive regulation of interleukin-6-mediated signaling pathway;GO:0071222|cellular response to lipopolysaccharide;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0016363|nuclear matrix;GO:0016604|nuclear body;GO:0017053|transcriptional repressor complex;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003700|DNA-binding transcription factor activity;GO:0005515|protein binding;GO:0046872|metal ion binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09223","GFI1; growth factor independent 1"]
["ENSRNOG00000013829",15,1.245399908,2,0.128660876,9.679709505,3.274963752,0.000162014,1.81934E-4,"up","yes","Chrna3","protein_coding","chr8:55401702-55415165:-","gi|113061|sp|P04757.1|ACHA3_RAT",2365,0,"RecName: Full=Neuronal acetylcholine receptor subunit alpha-3; Flags: Precursor","gi|55583|emb|X03440.1|",1907,0,"Rat mRNA for neuronal acetylcholine receptor alpha-3 chain subunit","P04757",913,0,"Neuronal acetylcholine receptor subunit alpha-3",".",".",".",".","pfam02931","Neur_chan_LBD","Neurotransmitter-gated ion-channel ligand binding domain. This family is the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.","GO:0006937|regulation of muscle contraction;GO:0006940|regulation of smooth muscle contraction;GO:0007165|signal transduction;GO:0007171|activation of transmembrane receptor protein tyrosine kinase activity;GO:0007268|chemical synaptic transmission;GO:0007271|synaptic transmission, cholinergic;GO:0007399|nervous system development;GO:0007507|heart development;GO:0007626|locomotory behavior;GO:0009410|response to xenobiotic stimulus;GO:0010035|response to inorganic substance;GO:0014056|regulation of acetylcholine secretion, neurotransmission;GO:0034220|ion transmembrane transport;GO:0035094|response to nicotine;GO:0035095|behavioral response to nicotine;GO:0042391|regulation of membrane potential;GO:0048814|regulation of dendrite morphogenesis;GO:0050877|nervous system process;GO:0060079|excitatory postsynaptic potential;GO:0060084|synaptic transmission involved in micturition;GO:0095500|acetylcholine receptor signaling pathway;GO:1905144|response to acetylcholine;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0005887|integral component of plasma membrane;GO:0005892|acetylcholine-gated channel complex;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0030425|dendrite;GO:0032991|protein-containing complex;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0044853|plasma membrane raft;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0098691|dopaminergic synapse;GO:0098981|cholinergic synapse;GO:0099060|integral component of postsynaptic specialization membrane;","GO:0015464|acetylcholine receptor activity;GO:0022848|acetylcholine-gated cation-selective channel activity;GO:0030594|neurotransmitter receptor activity;GO:0042166|acetylcholine binding;GO:0044877|protein-containing complex binding;GO:1901363|heterocyclic compound binding;GO:1904315|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K04805","CHRNA3; nicotinic acetylcholine receptor alpha-3"]
["ENSRNOG00000038197",15,1.245399908,2,0.128660876,9.679709505,3.274963752,0.000162014,1.81934E-4,"up","yes","Cd226","protein_coding","chr18:82450568-82543051:+","gi|157817173|ref|NP_001100840.1|",1734,0,"CD226 antigen precursor [Rattus norvegicus]","gi|157817172|ref|NM_001107370.1|",2312,0,"Rattus norvegicus CD226 molecule (Cd226), mRNA","Q8K4F0",552,0,"CD226 antigen",".",".",".",".","pfam10565","NMDAR2_C","N-methyl D-aspartate receptor 2B3 C-terminus. This domain is found at the C-terminus of many NMDA-receptor proteins, many of which also carry the Ligated ion-channel family pfam00060 further upstream as well as the ANF_receptor family pfam01094. This region is predicted to be a large extra-cellular domain of the NMDA receptor proteins, being highly hydrophilic, and is thought to be integrally involved in the function of the receptor. The region also carries a number of potential N-glycosylation sites.","GO:0001816|cytokine production;GO:0002729|positive regulation of natural killer cell cytokine production;GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target;GO:0002891|positive regulation of immunoglobulin mediated immune response;GO:0008150|biological_process;GO:0032729|positive regulation of interferon-gamma production;GO:0033005|positive regulation of mast cell activation;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;GO:0050862|positive regulation of T cell receptor signaling pathway;GO:0060369|positive regulation of Fc receptor mediated stimulatory signaling pathway;","GO:0005575|cellular_component;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0005178|integrin binding;GO:0019901|protein kinase binding;GO:0050839|cell adhesion molecule binding;","K06567","CD226, DNAM1; CD226 antigen"]
["ENSRNOG00000069385",15,1.245399908,2,0.128660876,9.679709505,3.274963752,0.000162014,1.81934E-4,"up","yes","ENSRNOG00000069385","pseudogene","chr17:56133387-56135325:-","gi|831237725|ref|XP_012665030.1|",1961,0,"PREDICTED: heat shock cognate 71 kDa protein [Otolemur garnettii]","gi|683524058|ref|NG_029209.2|",648,0,"Rattus norvegicus heat shock cognate 71 kDa protein-like (LOC100363133) pseudogene on chromosome 5","P63018",642,0,"Heat shock cognate 71 kDa protein","SPAC13G7.02c",470,{"v":1e-158,"d":"1.00E-158"},"COG0443","pfam00012","HSP70","Hsp70 protein. Hsp70 chaperones help to fold many proteins. Hsp70 assisted folding involves repeated cycles of substrate binding and release. Hsp70 activity is ATP dependent. Hsp70 proteins are made up of two regions: the amino terminus is the ATPase domain and the carboxyl terminus is the substrate binding region.",".",".",".",".","."]
["ENSRNOG00000055858",22,1.826586532,6,0.385982629,4.732302425,2.242542274,0.000183484,2.04785E-4,"up","yes","Myb","protein_coding","chr1:15939761-15973057:-","gi|564296048|ref|XP_006222900.1|",3674,0,"PREDICTED: transcriptional activator Myb isoform X1 [Rattus norvegicus]","gi|672012493|ref|XM_006222838.2|",5802,0,"PREDICTED: Rattus norvegicus similar to Myb proto-oncogene protein (C-myb) (predicted) (RGD1560020_predicted), transcript variant X1, mRNA","P06876",733,0,"Transcriptional activator Myb","ECU11g1690",154,{"v":2e-40,"d":"2.00E-40"},"COG5147","pfam09316","Cmyb_C","C-myb, C-terminal. Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumorigenesis.","GO:0000082|G1/S transition of mitotic cell cycle;GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001666|response to hypoxia;GO:0001701|in utero embryonic development;GO:0006338|chromatin remodeling;GO:0006355|regulation of transcription, DNA-templated;GO:0006816|calcium ion transport;GO:0010468|regulation of gene expression;GO:0017145|stem cell division;GO:0030099|myeloid cell differentiation;GO:0030183|B cell differentiation;GO:0032967|positive regulation of collagen biosynthetic process;GO:0043525|positive regulation of neuron apoptotic process;GO:0045624|positive regulation of T-helper cell differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048536|spleen development;GO:0048538|thymus development;GO:0048566|embryonic digestive tract development;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0048872|homeostasis of number of cells;GO:0051571|positive regulation of histone H3-K4 methylation;GO:0051574|positive regulation of histone H3-K9 methylation;GO:0060252|positive regulation of glial cell proliferation;GO:0070301|cellular response to hydrogen peroxide;GO:0071300|cellular response to retinoic acid;GO:0071354|cellular response to interleukin-6;GO:0071636|positive regulation of transforming growth factor beta production;GO:1901216|positive regulation of neuron death;GO:1901533|negative regulation of hematopoietic progenitor cell differentiation;GO:1904899|positive regulation of hepatic stellate cell proliferation;GO:1990830|cellular response to leukemia inhibitory factor;GO:2000491|positive regulation of hepatic stellate cell activation;GO:2000845|positive regulation of testosterone secretion;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0071987|WD40-repeat domain binding;","K09420","MYB, C-MYB; transcriptional activator Myb"]
["ENSRNOG00000015027",40,3.321066421,19,1.222278326,2.71711144,1.442073738,0.000194404,2.16181E-4,"up","yes","Il18r1","protein_coding","chr9:42727869-42760715:+","gi|672064859|ref|XP_008765240.1|",1436,0,"PREDICTED: interleukin-18 receptor 1 isoform X2 [Rattus norvegicus]","gi|240255474|ref|NM_001106905.2|",1176,0,"Rattus norvegicus interleukin 18 receptor 1 (Il18r1), mRNA","Q61098",447,{"v":1e-143,"d":"1.00E-143"},"Interleukin-18 receptor 1",".",".",".",".","pfam01582","TIR","TIR domain. The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.","GO:0008150|biological_process;GO:0030101|natural killer cell activation;GO:0032729|positive regulation of interferon-gamma production;GO:0035655|interleukin-18-mediated signaling pathway;GO:0045063|T-helper 1 cell differentiation;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0120163|negative regulation of cold-induced thermogenesis;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:2000556|positive regulation of T-helper 1 cell cytokine production;","GO:0005575|cellular_component;GO:0045092|interleukin-18 receptor complex;","GO:0003674|molecular_function;GO:0003953|NAD+ nucleosidase activity;GO:0042007|interleukin-18 binding;GO:0042008|interleukin-18 receptor activity;","K05173","IL18R1, IL1RRP, CD218a; interleukin 18 receptor 1"]
["ENSRNOG00000021996",25,2.075666513,8,0.514643505,4.033212294,2.011929346,1.96536E-4,0.000218346,"up","yes","Nlrp4","protein_coding","chr1:68089321-68127521:-","gi|685156911|ref|NP_001165635.2|",5052,0,"NLR family, pyrin domain containing 4 [Rattus norvegicus]","gi|685156910|ref|NM_001172164.2|",3387,0,"Rattus norvegicus NLR family, pyrin domain containing 4 (Nlrp4), mRNA","Q3TKR3",1744,0,"NACHT, LRR and PYD domains-containing protein 4C",".",".",".",".","pfam05729","NACHT","NACHT domain. This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.",".",".",".","K22265","NLRP4; NACHT, LRR and PYD domains-containing protein 4"]
["ENSRNOG00000037687",25,2.075666513,8,0.514643505,4.033212294,2.011929346,1.96536E-4,0.000218346,"up","yes","Rspo2","protein_coding","chr7:74103090-74238933:-","gi|194474018|ref|NP_001124047.1|",1195,{"v":5e-153,"d":"5.00E-153"},"R-spondin-2 precursor [Rattus norvegicus]","gi|194474017|ref|NM_001130575.1|",3223,0,"Rattus norvegicus R-spondin 2 (Rspo2), mRNA","Q8BFU0",425,{"v":6e-139,"d":"6.00E-139"},"R-spondin-2",".",".",".",".","pfam03302","VSP","Giardia variant-specific surface protein.","GO:0001649|osteoblast differentiation;GO:0008150|biological_process;GO:0016055|Wnt signaling pathway;GO:0030177|positive regulation of Wnt signaling pathway;GO:0030282|bone mineralization;GO:0035115|embryonic forelimb morphogenesis;GO:0035116|embryonic hindlimb morphogenesis;GO:0042489|negative regulation of odontogenesis of dentin-containing tooth;GO:0060173|limb development;GO:0060437|lung growth;GO:0060441|epithelial tube branching involved in lung morphogenesis;GO:0060535|trachea cartilage morphogenesis;GO:0071542|dopaminergic neuron differentiation;GO:0090263|positive regulation of canonical Wnt signaling pathway;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0009986|cell surface;","GO:0003674|molecular_function;GO:0005102|signaling receptor binding;GO:0008201|heparin binding;","K23097","RSPO2; R-spondin 2"]
["ENSRNOG00000012390",36,2.988959779,16,1.029287011,2.903912851,1.537998158,2.08941E-4,2.3122E-4,"up","yes","Npw","protein_coding","chr10:13680321-13681586:-","gi|23463263|ref|NP_695206.1|",757,{"v":9e-99,"d":"9.00E-99"},"neuropeptide W precursor [Rattus norvegicus]","gi|23463262|ref|NM_153294.1|",684,0,"Rattus norvegicus neuropeptide W (Npw), mRNA","Q8K1M5",296,{"v":3e-100,"d":"3.00E-100"},"Neuropeptide W",".",".",".",".","pfam15180","NPBW","Neuropeptides B and W. The function of this family, NPBW, which includes Neuropeptides B and W, is thought to be involved in activating G-protein coupled receptors, GPR7 and GPR8. It is thought to play a regulatory role in the organisation of neuroendocrine signals accessing the anterior pituitary gland. It is predicted that this effect will stimulate the increase in water-drinking and food-intake. This suggests it plays a role in the hypothalamic response to stress. This family of proteins is found in eukaryotes.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0007218|neuropeptide signaling pathway;GO:0007631|feeding behavior;","GO:0005576|extracellular region;","GO:0001664|G protein-coupled receptor binding;","K23141","NPW; neuropeptide W"]
["ENSRNOG00000054460",36,2.988959779,16,1.029287011,2.903912851,1.537998158,2.08941E-4,2.3122E-4,"up","yes","Khdc3","protein_coding","chr8:73842344-73844248:+","gi|157820007|ref|NP_001100307.1|",2206,0,"KH domain-containing protein 3 [Rattus norvegicus]","gi|157820006|ref|NM_001106837.1|",1600,0,"Rattus norvegicus KH domain containing 3, subcortical maternal complex member (Khdc3), mRNA","D3ZVV1",854,0,"KH domain-containing protein 3",".",".",".",".","pfam06346","Drf_FH1","Formin Homology Region 1. This region is found in some of the Diaphanous related formins (Drfs). It consists of low complexity repeats of around 12 residues.","GO:0006468|protein phosphorylation;GO:0007015|actin filament organization;GO:0007094|mitotic spindle assembly checkpoint;GO:0031297|replication fork processing;GO:0032880|regulation of protein localization;GO:0040019|positive regulation of embryonic development;GO:0043066|negative regulation of apoptotic process;GO:0050769|positive regulation of neurogenesis;GO:0051656|establishment of organelle localization;GO:0090307|mitotic spindle assembly;GO:1900006|positive regulation of dendrite development;GO:1905168|positive regulation of double-strand break repair via homologous recombination;GO:2000781|positive regulation of double-strand break repair;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005813|centrosome;GO:0005938|cell cortex;GO:0032991|protein-containing complex;GO:0045179|apical cortex;","GO:0003723|RNA binding;","K25076","KHDC3; KH domain-containing protein 3"]
["ENSRNOG00000008405",70,5.811866237,45,2.894869718,2.007643453,1.005503077,2.09645E-4,0.000231879,"up","yes","Taco1","protein_coding","chr10:91002640-91012042:+","gi|157819487|ref|NP_001101772.1|",1412,0,"translational activator of cytochrome c oxidase 1 [Rattus norvegicus]","gi|187469111|gb|BC166900.1|",1495,0,"Rattus norvegicus coiled-coil domain containing 44, mRNA (cDNA clone MGC:188861 IMAGE:6922142), complete cds","B2RYT9",548,0,"Translational activator of cytochrome c oxidase 1","TM0466",120,{"v":8e-29,"d":"8.00E-29"},"COG0217","pfam01709","Transcrip_reg","Transcriptional regulator. This is a family of transcriptional regulators. In mammals, it activates the transcription of mitochondrially-encoded COX1. In bacteria, it negatively regulates the quorum-sensing response regulator by binding to its promoter region.","GO:0033617|mitochondrial respiratory chain complex IV assembly;GO:0061743|motor learning;GO:0070129|regulation of mitochondrial translation;GO:1904959|regulation of cytochrome-c oxidase activity;","GO:0005739|mitochondrion;","GO:0003729|mRNA binding;GO:0019843|rRNA binding;GO:0097177|mitochondrial ribosome binding;","K18189","TACO1; translational activator of cytochrome c oxidase 1"]
["ENSRNOG00000069239",32,2.656853137,13,0.836295696,3.176930299,1.667633438,2.10266E-4,2.32525E-4,"up","yes","ENSRNOG00000069239","protein_coding","chr10:38104122-38130671:-","gi|109490712|ref|XP_001073573.1|",1735,0,"PREDICTED: solute carrier family 22 member 21 [Rattus norvegicus]","gi|73254762|gb|DQ119106.1|",2862,0,"Rattus norvegicus mRNA stabilizer 2b1 splice variant mRNA, complete cds, alternatively spliced","Q9WTN6",599,0,"Solute carrier family 22 member 21",".",".",".",".","pfam00083","Sugar_tr","Sugar (and other) transporter.",".",".",".",".","."]
["ENSRNOG00000011316",48,3.985279705,26,1.672591393,2.382697724,1.252595939,0.000248452,0.000271786,"up","yes","Fam167a","protein_coding","chr15:37700919-37715469:+","gi|157819299|ref|NP_001102572.1|",1111,{"v":7e-140,"d":"7.00E-140"},"protein FAM167A [Rattus norvegicus]","gi|672078366|ref|XM_008770772.1|",3483,0,"PREDICTED: Rattus norvegicus family with sequence similarity 167, member A (Fam167a), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam11652","DUF3259","Protein of unknown function (DUF3259). This eukaryotic family of proteins has no known function.",".",".",".",".","."]
["ENSRNOG00000046191",48,3.985279705,26,1.672591393,2.382697724,1.252595939,0.000248452,0.000271786,"up","yes","Cgas","protein_coding","chr8:79294511-79305496:-","gi|109485035|ref|XP_001060106.1|",2252,0,"PREDICTED: cyclic GMP-AMP synthase isoform X1 [Rattus norvegicus]","gi|672023102|ref|XM_001060106.3|",1903,0,"PREDICTED: Rattus norvegicus Mab-21 domain containing 1 (Mb21d1), transcript variant X1, mRNA","Q8C6L5",777,0,"Cyclic GMP-AMP synthase",".",".",".",".","pfam03281","Mab-21","Mab-21 protein. This family contains Mab-21 and Mab-21 like proteins. In C. elegans these proteins are required for several aspects of embryonic development.","GO:0002218|activation of innate immune response;GO:0002230|positive regulation of defense response to virus by host;GO:0002637|regulation of immunoglobulin production;GO:0006974|cellular response to DNA damage stimulus;GO:0008340|determination of adult lifespan;GO:0010753|positive regulation of cGMP-mediated signaling;GO:0032479|regulation of type I interferon production;GO:0032481|positive regulation of type I interferon production;GO:0038001|paracrine signaling;GO:0043950|positive regulation of cAMP-mediated signaling;GO:0050776|regulation of immune response;GO:0050863|regulation of T cell activation;GO:0051607|defense response to virus;GO:0071360|cellular response to exogenous dsRNA;GO:2000042|negative regulation of double-strand break repair via homologous recombination;GO:2000774|positive regulation of cellular senescence;","GO:0005634|nucleus;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0035861|site of double-strand break;","GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003690|double-stranded DNA binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0061501|cyclic-GMP-AMP synthase activity;","K17834","MB21D1; cyclic GMP-AMP synthase [EC:2.7.7.86]"]
["ENSRNOG00000006104",33,2.739879797,14,0.900626135,3.042194416,1.605112353,2.50086E-4,2.73322E-4,"up","yes","Tg","protein_coding","chr7:98418293-98603210:+","gi|398650654|ref|NP_112250.2|",14647,0,"thyroglobulin isoform 1 precursor [Rattus norvegicus]","gi|398650653|ref|NM_030988.2|",8461,0,"Rattus norvegicus thyroglobulin (Tg), transcript variant 1, mRNA","P06882",5637,0,"Thyroglobulin","BS_pnbA",165,{"v":2E-41,"d":"2.00E-41"},"COG2272","pfam00135","COesterase","Carboxylesterase family.","GO:0006590|thyroid hormone generation;GO:0007165|signal transduction;GO:0009268|response to pH;GO:0015705|iodide transport;GO:0030878|thyroid gland development;GO:0031641|regulation of myelination;GO:0032496|response to lipopolysaccharide;GO:0042403|thyroid hormone metabolic process;GO:0042446|hormone biosynthetic process;GO:0045056|transcytosis;","GO:0005615|extracellular space;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0032991|protein-containing complex;GO:0048471|perinuclear region of cytoplasm;","GO:0005102|signaling receptor binding;GO:0005179|hormone activity;GO:0005515|protein binding;GO:0042802|identical protein binding;GO:0043168|anion binding;GO:0044877|protein-containing complex binding;GO:0051087|chaperone binding;","K10809","TG; thyroglobulin"]
["ENSRNOG00000000257",26,2.158693174,9,0.578973944,3.728480698,1.898587873,0.000257858,0.000281264,"up","yes","Smpd3","protein_coding","chr19:34162341-34245749:-","gi|564395627|ref|XP_006255605.1|",3302,0,"PREDICTED: sphingomyelin phosphodiesterase 3 isoform X1 [Rattus norvegicus]","gi|16758393|ref|NM_053605.1|",4972,0,"Rattus norvegicus sphingomyelin phosphodiesterase 3, neutral membrane (Smpd3), mRNA","O35049",1273,0,"Sphingomyelin phosphodiesterase 3",".",".",".",".","pfam03372","Exo_endo_phos","Endonuclease/Exonuclease/phosphatase family. This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins EC:4.2.99.18, DNase I proteins EC:3.1.21.1, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56, Sphingomyelinase EC:3.1.4.12 and Nocturnin.","GO:0001501|skeletal system development;GO:0001503|ossification;GO:0001932|regulation of protein phosphorylation;GO:0001958|endochondral ossification;GO:0002063|chondrocyte development;GO:0002244|hematopoietic progenitor cell differentiation;GO:0002685|regulation of leukocyte migration;GO:0003433|chondrocyte development involved in endochondral bone morphogenesis;GO:0006665|sphingolipid metabolic process;GO:0006672|ceramide metabolic process;GO:0006684|sphingomyelin metabolic process;GO:0006685|sphingomyelin catabolic process;GO:0007165|signal transduction;GO:0007568|aging;GO:0014824|artery smooth muscle contraction;GO:0015774|polysaccharide transport;GO:0030072|peptide hormone secretion;GO:0030282|bone mineralization;GO:0030324|lung development;GO:0030509|BMP signaling pathway;GO:0032963|collagen metabolic process;GO:0034614|cellular response to reactive oxygen species;GO:0035264|multicellular organism growth;GO:0043491|protein kinase B signaling;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0045840|positive regulation of mitotic nuclear division;GO:0048008|platelet-derived growth factor receptor signaling pathway;GO:0048286|lung alveolus development;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0051216|cartilage development;GO:0051481|negative regulation of cytosolic calcium ion concentration;GO:0060348|bone development;GO:0060541|respiratory system development;GO:0061035|regulation of cartilage development;GO:0070301|cellular response to hydrogen peroxide;GO:0070314|G1 to G0 transition;GO:0071286|cellular response to magnesium ion;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071461|cellular response to redox state;GO:0071897|DNA biosynthetic process;GO:0085029|extracellular matrix assembly;GO:0090494|dopamine uptake;GO:0090520|sphingolipid mediated signaling pathway;GO:0097187|dentinogenesis;GO:0098868|bone growth;GO:0140014|mitotic nuclear division;GO:0140052|cellular response to oxidised low-density lipoprotein particle stimulus;GO:1900125|regulation of hyaluronan biosynthetic process;GO:1900126|negative regulation of hyaluronan biosynthetic process;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1901653|cellular response to peptide;GO:1903543|positive regulation of exosomal secretion;GO:2000304|positive regulation of ceramide biosynthetic process;","GO:0000137|Golgi cis cisterna;GO:0000139|Golgi membrane;GO:0005576|extracellular region;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0001786|phosphatidylserine binding;GO:0004620|phospholipase activity;GO:0004767|sphingomyelin phosphodiesterase activity;GO:0005515|protein binding;GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0061751|neutral sphingomyelin phosphodiesterase activity;GO:0070300|phosphatidic acid binding;","K12352","SMPD3; sphingomyelin phosphodiesterase 3 [EC:3.1.4.12]"]
["ENSRNOG00000070065",23,1.909613192,7,0.450313067,4.24063464,2.08428019,0.000258468,0.000281834,"up","yes","ENSRNOG00000070065","lncRNA","chr2:20869527-20870649:+","gi|149039003|gb|EDL93223.1|",527,{"v":4e-63,"d":"4.00E-63"},"adenylate kinase 1, isoform CRA_b [Rattus norvegicus]","gi|467091434|ref|NM_024349.3|",1067,0,"Rattus norvegicus adenylate kinase 1 (Ak1), mRNA",".",".",".",".",".",".",".",".","pfam03441","FAD_binding_7","FAD binding domain of DNA photolyase.",".",".",".",".","."]
["ENSRNOG00000067991",18,1.494479889,4,0.257321753,5.807825703,2.537998158,0.000274457,0.000298149,"up","yes","ENSRNOG00000067991","lncRNA","chr14:66856155-66873358:-","gi|74226034|dbj|BAE28765.1|",236,{"v":3e-21,"d":"3.00E-21"},"unnamed protein product [Mus musculus]","gi|672028002|ref|XR_593873.1|",668,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102552900 (LOC102552900), transcript variant X1, ncRNA",".",".",".",".",".",".",".",".","pfam03157","Glutenin_hmw","High molecular weight glutenin subunit. Members of this family include high molecular weight subunits of glutenin. This group of gluten proteins is thought to be largely responsible for the elastic properties of gluten, and hence, doughs. Indeed, glutenin high molecular weight subunits are classified as elastomeric proteins, because the glutenin network can withstand significant deformations without breaking, and return to the original conformation when the stress is removed. Elastomeric proteins differ considerably in amino acid sequence, but they are all polymers whose subunits consist of elastomeric domains, composed of repeated motifs, and non-elastic domains that mediate cross-linking between the subunits. The elastomeric domain motifs are all rich in glycine residues in addition to other hydrophobic residues. High molecular weight glutenin subunits have an extensive central elastomeric domain, flanked by two terminal non-elastic domains that form disulphide cross-links. The central elastomeric domain is characterized by the following three repeated motifs: PGQGQQ, GYYPTS[P/L]QQ, GQQ. It possesses overlapping beta-turns within and between the repeated motifs, and assumes a regular helical secondary structure with a diameter of approx. 1.9 nm and a pitch of approx. 1.5 nm.",".",".",".",".","."]
["ENSRNOG00000026759",11,0.913293266,0,0.032165219,28.39381455,4.827504775,0.000274556,0.000298206,"up","yes","Ccr8","protein_coding","chr8:119826568-119827629:+","gi|672023455|ref|XP_008756107.1|",1718,0,"PREDICTED: C-C chemokine receptor type 8 [Rattus norvegicus]","gi|672023454|ref|XM_008757885.1|",1062,0,"PREDICTED: Rattus norvegicus chemokine (C-C motif) receptor 8 (Ccr8), mRNA","P56484",616,0,"C-C chemokine receptor type 8",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0006935|chemotaxis;GO:0006955|immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0019722|calcium-mediated signaling;GO:0060326|cell chemotaxis;GO:0070098|chemokine-mediated signaling pathway;","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0016493|C-C chemokine receptor activity;GO:0019957|C-C chemokine binding;","K04183","CCR8, CDw198; C-C chemokine receptor type 8"]
["ENSRNOG00000067207",57,4.73251965,34,2.187234898,2.163699772,1.113500329,0.000277101,3.00766E-4,"up","yes","ENSRNOG00000067207","lncRNA","chr7:122821943-122826368:-","gi|149017598|gb|EDL76602.1|",238,{"v":2e-20,"d":"2.00E-20"},"rCG59223 [Rattus norvegicus]","gi|49170118|gb|AC112081.8|",3722,0,"Rattus norvegicus 7 BAC CH230-192B8 (Children's Hospital Oakland Research Institute) complete sequence","P11369",60.5,1e-07,"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam13687","DUF4153","Domain of unknown function (DUF4153). Members of this family are annotated as putative inner membrane proteins.",".",".",".",".","."]
["ENSRNOG00000007270",34,2.822906458,15,0.964956573,2.925423317,1.548645402,2.92627E-4,0.000316436,"up","yes","Il12rb2","protein_coding","chr4:96426842-96515289:-","gi|300795677|ref|NP_001178679.1|",4542,0,"interleukin-12 receptor subunit beta-2 precursor [Rattus norvegicus]","gi|672049893|ref|XM_006236613.2|",3214,0,"PREDICTED: Rattus norvegicus interleukin 12 receptor, beta 2 (Il12rb2), transcript variant X1, mRNA","P97378",1558,0,"Interleukin-12 receptor subunit beta-2",".",".",".",".","pfam06328","Lep_receptor_Ig","Ig-like C2-type domain. This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.","GO:0018108|peptidyl-tyrosine phosphorylation;GO:0019221|cytokine-mediated signaling pathway;GO:0032496|response to lipopolysaccharide;GO:0032729|positive regulation of interferon-gamma production;GO:0034097|response to cytokine;GO:0045622|regulation of T-helper cell differentiation;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0043235|receptor complex;","GO:0004896|cytokine receptor activity;GO:0019901|protein kinase binding;GO:0019955|cytokine binding;","K05064","IL12RB2; interleukin 12 receptor beta-2"]
["ENSRNOG00000014979",12,0.996319926,1,0.064330438,15.48753521,3.953035657,0.00029375,0.000317597,"up","yes","Themis","protein_coding","chr1:16432631-16664329:-","gi|149039656|gb|EDL93818.1|",3298,0,"rCG57294, isoform CRA_a [Rattus norvegicus]","gi|672033934|ref|XM_008758640.1|",2293,0,"PREDICTED: Rattus norvegicus thymocyte selection associated (Themis), transcript variant X2, mRNA","Q8BGW0",1158,0,"Protein THEMIS",".",".",".",".","pfam12736","CABIT","Cell-cycle sustaining, positive selection,. The 'CABIT' domain (for 'cysteine-containing, all- in Themis') is found in a newly identified gene family that has three mammalian homologues (Themis, Icb1 and 9130404H23Rik) that encode proteins with two CABIT domains and a highly conserved proline-rich region. In contrast, Fam59A, Fam59B and related proteins from mammals to cnidarians, including the insect Serrano proteins, have a single copy of the CABIT domain, a proline-rich region and often a C-terminal SAM (sterile-motif) domain. Multiple-sequence alignment has predicted that the CABIT domain adopts an all-strand structure with at least 12 strands, ie a dyad of six-stranded beta-barrel units. The CABIT domain contains a nearly absolutely conserved cysteine residue which is likely to be central to its function. CABIT domain proteins function downstream of tyrosine kinase signalling and interact with GRB2.","GO:0043368|positive T cell selection;GO:0043383|negative T cell selection;GO:0050852|T cell receptor signaling pathway;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005911|cell-cell junction;GO:0008180|COP9 signalosome;",".",".","."]
["ENSRNOG00000018485",44,3.653173063,23,1.479600078,2.469027352,1.303942819,2.95381E-4,0.000319253,"up","yes","Gpr155","protein_coding","chr3:58216423-58270275:-","gi|157821855|ref|NP_001101281.1|",4064,0,"integral membrane protein GPR155 [Rattus norvegicus]","gi|157821854|ref|NM_001107811.1|",4810,0,"Rattus norvegicus G protein-coupled receptor 155 (Gpr155), mRNA","Q7Z3F1",1402,0,"Integral membrane protein GPR155",".",".",".",".","pfam03547","Mem_trans","Membrane transport protein. This family includes auxin efflux carrier proteins and other transporter proteins from all domains of life.","GO:0035556|intracellular signal transduction;GO:0050890|cognition;GO:0055085|transmembrane transport;","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000000854",39,3.23803976,19,1.222278326,2.649183654,1.405547862,0.000307515,0.000331359,"up","yes","Ncr3","protein_coding","chr20:3638240-3643799:-","gi|260166676|ref|NP_861543.2|",917,{"v":2E-121,"d":"2.00E-121"},"natural cytotoxicity triggering receptor 3 precursor [Rattus norvegicus]","gi|30314389|gb|AY273824.1|",899,0,"Rattus norvegicus NKp30 (Nkp30) mRNA, complete cds","Q8CFD9",348,{"v":1E-119,"d":"1.00E-119"},"Natural cytotoxicity triggering receptor 3",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0002429|immune response-activating cell surface receptor signaling pathway;GO:0030101|natural killer cell activation;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0042802|identical protein binding;","K06743","NCR3, CD337; natural cytotoxicity triggering receptor 3"]
["ENSRNOG00000011028",14,1.162373247,2,0.128660876,9.034395538,3.175428078,0.000324748,0.000348577,"up","yes","Cfap61","protein_coding","chr3:133354197-133633320:+","gi|672017484|ref|XP_008773774.1|",6384,0,"PREDICTED: uncharacterized protein C20orf26 homolog isoform X2 [Rattus norvegicus]","gi|672017483|ref|XM_008775552.1|",3976,0,"PREDICTED: Rattus norvegicus hypothetical LOC311496 (RGD1311519), transcript variant X3, mRNA","Q8CEL2",2177,0,"Cilia- and flagella-associated protein 61",".",".",".",".","pfam09536","DUF2378","Protein of unknown function (DUF2378). This family consists of a set of at least 17 paralogous proteins in Myxococcus xanthus DK 1622 and and 12 in Stigmatella aurantiaca DW4/3-1. Members are about 200 amino acids in length. The function is unknown.",".",".",".","K25460","CFAP61; cilia- and flagella-associated protein 61"]
["ENSRNOG00000020901",14,1.162373247,2,0.128660876,9.034395538,3.175428078,0.000324748,0.000348577,"up","yes","S1pr5","protein_coding","chr8:19786663-19791795:-","gi|564362665|ref|XP_006242725.1|",1399,0,"PREDICTED: sphingosine 1-phosphate receptor 5 isoform X1 [Rattus norvegicus]","gi|31377520|ref|NM_021775.2|",2147,0,"Rattus norvegicus sphingosine-1-phosphate receptor 5 (S1pr5), mRNA","Q9JKM5",543,0,"Sphingosine 1-phosphate receptor 5",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0003376|sphingosine-1-phosphate receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0019222|regulation of metabolic process;GO:0045664|regulation of neuron differentiation;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0038036|sphingosine-1-phosphate receptor activity;","K04295","S1PR5, EDG8; sphingosine 1-phosphate receptor 5"]
["ENSRNOG00000015850",27,2.241719834,10,0.643304382,3.484695422,1.801032563,0.000327121,0.000350829,"up","yes","Rbp7","protein_coding","chr5:159889723-159894339:-","gi|157822745|ref|NP_001102163.1|",543,{"v":3e-67,"d":"3.00E-67"},"retinoid-binding protein 7 [Rattus norvegicus]","gi|157822744|ref|NM_001108693.1|",500,0,"Rattus norvegicus retinol binding protein 7 (Rbp7), mRNA","Q9EPC5",201,{"v":9e-64,"d":"9.00E-64"},"Retinoid-binding protein 7",".",".",".",".","pfam01146","Caveolin","Caveolin. All three known Caveolin forms have the FEDVIAEP caveolin 'signature motif' within their hydrophilic N-terminal domain. Caveolin 2 (Cav-2) is co-localized and co-expressed with Cav-1/VIP21, forms heterodimers with it and needs Cav-1 for proper membrane localisation. Cav-3 has greater protein sequence similarity to Cav-1 than to Cav-2. Cellular processes caveolins are involved in include vesicular transport, cholesterol homeostasis, signal transduction, and tumor suppression.",".",".","GO:0005501|retinoid binding;",".","."]
["ENSRNOG00000036831",27,2.241719834,10,0.643304382,3.484695422,1.801032563,0.000327121,0.000350829,"up","yes","Gtsf1","protein_coding","chr7:134539329-134557424:-","gi|564362011|ref|XP_006242465.1|",1000,{"v":1E-135,"d":"1.00E-135"},"PREDICTED: gametocyte-specific factor 1 isoform X2 [Rattus norvegicus]","gi|854281263|ref|NM_001079707.2|",679,0,"Rattus norvegicus gametocyte specific factor 1 (Gtsf1), mRNA","Q9DAN6",353,{"v":2e-123,"d":"2.00E-123"},"Gametocyte-specific factor 1",".",".",".",".","pfam05253","zf-U11-48K","U11-48K-like CHHC zinc finger. This zinc binding domain has four conserved zinc chelating residues in a CHHC pattern. This domain is predicted to have an RNA-binding function.","GO:0007283|spermatogenesis;","GO:0005737|cytoplasm;","GO:0046872|metal ion binding;",".","."]
["ENSRNOG00000067849",27,2.241719834,10,0.643304382,3.484695422,1.801032563,0.000327121,0.000350829,"up","yes","ENSRNOG00000067849","protein_coding","chr20:20525256-20609951:-","gi|564397720|ref|XP_006256429.1|",3193,0,"PREDICTED: rhotekin-2 isoform X1 [Rattus norvegicus]","gi|672086204|ref|XM_006256367.2|",3588,0,"PREDICTED: Rattus norvegicus rhotekin 2 (Rtkn2), transcript variant X1, mRNA","Q14B46",1097,0,"Rhotekin-2",".",".",".",".","pfam08174","Anillin","Cell division protein anillin. Anillin is a protein involved in septin organisation during cell division.  It is an actin binding protein that is localized to the cleavage furrow, and it maintains the localisation of active myosin, which ensures the spatial control of concerted contraction during cytokinesis.",".",".",".",".","."]
["ENSRNOG00000016920",35,2.905933118,16,1.029287011,2.823248606,1.497356173,0.00033755,3.61166E-4,"up","yes","Spire2","protein_coding","chr19:51373228-51411920:+","gi|149038446|gb|EDL92806.1|",3069,0,"rCG51060 [Rattus norvegicus]","gi|189011678|ref|NM_001127538.1|",1992,0,"Rattus norvegicus spire-type actin nucleation factor 2 (Spire2), mRNA","Q8K1S6",1104,0,"Protein spire homolog 2",".",".",".",".","pfam12004","DUF3498","Domain of unknown function (DUF3498). This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 433 to 538 amino acids in length. This domain is found associated with pfam00616, pfam00168. This domain has two conserved sequence motifs: DLQ and PLSFQNP.","GO:0015031|protein transport;GO:0016192|vesicle-mediated transport;GO:0030036|actin cytoskeleton organization;GO:0030041|actin filament polymerization;GO:0036089|cleavage furrow formation;GO:0040038|polar body extrusion after meiotic divisions;GO:0045010|actin nucleation;GO:0046907|intracellular transport;GO:0048193|Golgi vesicle transport;GO:0051295|establishment of meiotic spindle localization;GO:0051639|actin filament network formation;GO:0070649|formin-nucleated actin cable assembly;GO:2000781|positive regulation of double-strand break repair;","GO:0005856|cytoskeleton;GO:0005938|cell cortex;GO:0030659|cytoplasmic vesicle membrane;GO:0032154|cleavage furrow;","GO:0003779|actin binding;","K02098","SPIR; spire"]
["ENSRNOG00000015503",40,3.321066421,20,1.286608764,2.581255868,1.368073156,3.42818E-4,0.000366496,"up","yes","Otud7a","protein_coding","chr1:117064496-117386480:+","gi|18700018|ref|NP_570950.1|",3665,0,"OTU domain-containing protein 7A [Mus musculus]","gi|672037216|ref|XM_008759566.1|",2948,0,"PREDICTED: Rattus norvegicus OTU deubiquitinase 7A (Otud7a), transcript variant X2, mRNA","Q8R554",1416,0,"OTU domain-containing protein 7A",".",".",".",".","pfam02338","OTU","OTU-like cysteine protease. This family is comprised of a group of predicted cysteine proteases, homologous to the Ovarian tumor (OTU) gene in Drosophila. Members include proteins from eukaryotes, viruses and pathogenic bacterium. The conserved cysteine and histidine, and possibly the aspartate, represent the catalytic residues in this putative group of proteases.","GO:0035871|protein K11-linked deubiquitination;",".","GO:0003677|DNA binding;GO:0004843|thiol-dependent ubiquitin-specific protease activity;GO:0008270|zinc ion binding;","K11860","OTUD7A_B; OTU domain-containing protein 7 [EC:3.4.19.12]"]
["ENSRNOG00000067076",62,5.147652953,39,2.508887089,2.051767485,1.036867248,0.000346014,0.000369665,"up","yes","Frat1","protein_coding","chr1:240638296-240640945:+","gi|37059812|ref|NP_032069.2|",986,{"v":3e-123,"d":"3.00E-123"},"proto-oncogene FRAT1 [Mus musculus]","gi|672040690|ref|XM_008760507.1|",2426,0,"PREDICTED: Rattus norvegicus frequently rearranged in advanced T-cell lymphomas 1 (Frat1), mRNA","P70339",384,{"v":1e-124,"d":"1.00E-124"},"Proto-oncogene FRAT1",".",".",".",".","pfam05350","GSK-3_bind","Glycogen synthase kinase-3 binding. Glycogen synthase kinase-3 (GSK-3) sequentially phosphorylates four serine residues on glycogen synthase (GS), in the sequence SxxxSxxxSxxx-SxxxS(p), by recognizing and phosphorylating the first serine in the sequence motif SxxxS(P) (where S(p) represents a phosphoserine). Interaction of GSK-3 with a peptide derived from GSK-3 binding protein (this family) prevents GSK-3 interaction with Axin. This interaction thereby inhibits the Axin-dependent phosphorylation of beta-catenin by GSK-3.",".",".",".",".","."]
["ENSRNOG00000004781",24,1.992639853,8,0.514643505,3.871883802,1.953035657,3.46585E-4,0.000370213,"up","yes","Crmp1","protein_coding","chr14:73509933-73556177:-","gi|148705576|gb|EDL37523.1|",3422,0,"collapsin response mediator protein 1, isoform CRA_b, partial [Mus musculus]","gi|672076375|ref|XM_006251084.2|",3069,0,"PREDICTED: Rattus norvegicus collapsin response mediator protein 1 (Crmp1), transcript variant X1, mRNA","Q62950",1053,0,"Dihydropyrimidinase-related protein 1","SMc01821",417,{"v":2e-133,"d":"2.00E-133"},"COG0044","pfam01979","Amidohydro_1","Amidohydrolase family. This family of enzymes are a a large metal dependent hydrolase superfamily. The family includes Adenine deaminase EC:3.5.4.2 that hydrolyses adenine to form hypoxanthine and ammonia. Adenine deaminases reaction is important for adenine utilisation as a purine and also as a nitrogen source. This family also includes dihydroorotase and N-acetylglucosamine-6-phosphate deacetylases, EC:3.5.1.25 These enzymes catalyse the reaction N-acetyl-D-glucosamine 6-phosphate + H2O <=> D-glucosamine 6-phosphate + acetate. This family includes the catalytic domain of urease alpha subunit. Dihydroorotases (EC:3.5.2.3) are also included.","GO:0000226|microtubule cytoskeleton organization;GO:0007411|axon guidance;GO:0010977|negative regulation of neuron projection development;GO:0048666|neuron development;GO:0071526|semaphorin-plexin signaling pathway;GO:1904530|negative regulation of actin filament binding;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0005819|spindle;GO:0005829|cytosol;GO:0015629|actin cytoskeleton;GO:0030425|dendrite;GO:0030426|growth cone;GO:0030496|midbody;GO:0043025|neuronal cell body;GO:0043204|perikaryon;","GO:0031005|filamin binding;GO:0042802|identical protein binding;GO:0051219|phosphoprotein binding;",".","."]
["ENSRNOG00000012546",31,2.573826476,13,0.836295696,3.077651227,1.621829748,0.000348817,0.000372287,"up","yes","Frmpd1","protein_coding","chr5:59443076-59545080:+","gi|564305255|ref|XP_006225341.1|",7705,0,"PREDICTED: FERM and PDZ domain-containing protein 1 [Rattus norvegicus]","gi|672019285|ref|XM_006225280.2|",4779,0,"PREDICTED: Rattus norvegicus FERM and PDZ domain containing 1 (Frmpd1), transcript variant X2, mRNA","A2AKB4",2631,0,"FERM and PDZ domain-containing protein 1",".",".",".",".","pfam00373","FERM_M","FERM central domain. This domain is the central structural domain of the FERM domain.","GO:0007165|signal transduction;GO:0008150|biological_process;GO:0008277|regulation of G protein-coupled receptor signaling pathway;GO:0090150|establishment of protein localization to membrane;","GO:0005575|cellular_component;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0005938|cell cortex;GO:0032991|protein-containing complex;","GO:0005515|protein binding;","K23954","FRMPD1; FERM and PDZ domain-containing protein 1"]
["ENSRNOG00000016243",31,2.573826476,13,0.836295696,3.077651227,1.621829748,0.000348817,0.000372287,"up","yes","Casq2","protein_coding","chr2:189525960-189582267:+","gi|47940716|gb|AAH72547.1|",1987,0,"Calsequestrin 2 (cardiac muscle) [Rattus norvegicus]","gi|76563945|ref|NM_017131.2|",2416,0,"Rattus norvegicus calsequestrin 2 (Casq2), mRNA","O09161",721,0,"Calsequestrin-2",".",".",".",".","pfam01216","Calsequestrin","Calsequestrin.","GO:0002027|regulation of heart rate;GO:0008150|biological_process;GO:0010649|regulation of cell communication by electrical coupling;GO:0010880|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0010881|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;GO:0043267|negative regulation of potassium ion transport;GO:0045214|sarcomere organization;GO:0051208|sequestering of calcium ion;GO:0051258|protein polymerization;GO:0051279|regulation of release of sequestered calcium ion into cytosol;GO:0060048|cardiac muscle contraction;GO:0060306|regulation of membrane repolarization;GO:0060315|negative regulation of ryanodine-sensitive calcium-release channel activity;GO:0071313|cellular response to caffeine;GO:0086004|regulation of cardiac muscle cell contraction;GO:1901017|negative regulation of potassium ion transmembrane transporter activity;","GO:0005737|cytoplasm;GO:0016529|sarcoplasmic reticulum;GO:0030018|Z disc;GO:0030314|junctional membrane complex;GO:0033018|sarcoplasmic reticulum lumen;","GO:0005080|protein kinase C binding;GO:0005509|calcium ion binding;GO:0042803|protein homodimerization activity;GO:0048306|calcium-dependent protein binding;","K23445","CASQ2; calsequestrin 2"]
["ENSRNOG00000027506",47,3.902253045,26,1.672591393,2.333058188,1.22222229,3.76201E-4,0.000400177,"up","yes","Zp4","protein_coding","chr17:59005649-59012202:-","gi|149055324|gb|EDM06978.1|",2876,0,"zona pellucida glycoprotein 4 [Rattus norvegicus]","gi|404425919|ref|NM_172330.3|",1708,0,"Rattus norvegicus zona pellucida glycoprotein 4 (Zp4), mRNA","Q8CH34",1093,0,"Zona pellucida sperm-binding protein 4",".",".",".",".","pfam00100","Zona_pellucida","Zona pellucida-like domain.","GO:0002922|positive regulation of humoral immune response;GO:0008150|biological_process;GO:0042102|positive regulation of T cell proliferation;GO:0060478|acrosomal vesicle exocytosis;GO:2000344|positive regulation of acrosome reaction;GO:2000360|negative regulation of binding of sperm to zona pellucida;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0035805|egg coat;","GO:0003674|molecular_function;GO:0032190|acrosin binding;GO:0035804|structural constituent of egg coat;GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000064738",19,1.57750655,5,0.321652191,4.904386149,2.294072575,0.000424112,0.000447125,"up","yes","Btnl8","protein_coding","chr20:4266794-4408167:+","gi|47059099|ref|NP_997654.1|",2853,0,"butyrophilin-like 8 [Rattus norvegicus]","gi|47059098|ref|NM_212489.1|",1838,0,"Rattus norvegicus butyrophilin-like 8 (Btnl8), mRNA","Q13410",351,{"v":1e-111,"d":"1.00E-111"},"Butyrophilin subfamily 1 member A1",".",".",".",".","pfam00622","SPRY","SPRY domain. SPRY Domain is named from SPla and the RYanodine Receptor. Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.",".",".",".",".","."]
["ENSRNOG00000066155",43,3.570146403,23,1.479600078,2.412913094,1.270775955,0.000453117,0.000475431,"up","yes","ENSRNOG00000066155","lncRNA","chr1:221567754-221569491:-",".",".",".",".","gi|672040017|ref|XM_006231185.2|",1738,0,"PREDICTED: Rattus norvegicus amyloid beta (A4) precursor protein-binding, family A, member 1 (Apba1), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.",".",".",".",".","."]
["ENSRNOG00000047061",22,1.826586532,7,0.450313067,4.056259221,2.020149853,0.000461496,0.000483509,"up","yes","Zfp773-ps1","protein_coding","chr1:66764123-66769428:+","gi|256773193|ref|NP_083860.1|",1854,0,"zinc finger protein LOC76373 [Mus musculus]","gi|755520186|ref|XR_881794.1|",1518,0,"PREDICTED: Mus musculus zinc finger protein 773 (Zfp773), transcript variant X1, misc_RNA","Q6PK81",371,{"v":7e-118,"d":"7.00E-118"},"Zinc finger protein 773",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006357|regulation of transcription by RNA polymerase II;",".","GO:0046872|metal ion binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSRNOG00000069699",22,1.826586532,7,0.450313067,4.056259221,2.020149853,0.000461496,0.000483509,"up","yes","Slc25a53","protein_coding","chrX:100306915-100319863:-","gi|149033185|gb|EDL87992.1|",1660,0,"rCG56853, isoform CRA_a [Rattus norvegicus]","gi|189027118|ref|NM_001127602.1|",2476,0,"Rattus norvegicus solute carrier family 25, member 53 (Slc25a53), mRNA","Q5H9E4",588,0,"Solute carrier family 25 member 53",".",".",".",".","pfam00153","Mito_carr","Mitochondrial carrier protein.",".",".",".",".","."]
["ENSRNOG00000063150",29,2.407773155,12,0.771965258,3.119017507,1.641091651,0.000486298,0.000507996,"up","yes","Rab42","protein_coding","chr5:144496215-144498848:-","gi|126116579|ref|NP_001075120.1|",1069,{"v":4e-138,"d":"4.00E-138"},"putative Ras-related protein Rab-42 [Mus musculus]","gi|672054317|ref|XM_008764194.1|",1417,0,"PREDICTED: Rattus norvegicus similar to RAB family member (rab-39) (LOC682865), mRNA","Q0PD08",416,{"v":1E-139,"d":"1.00E-139"},"Ras-related protein Rab-42","SPAC18G6.03",143,{"v":1e-37,"d":"1.00E-37"},"COG1100","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.",".",".",".",".","."]
["ENSRNOG00000068754",29,2.407773155,12,0.771965258,3.119017507,1.641091651,0.000486298,0.000507996,"up","yes","Cd244","protein_coding","chr13:84020095-84036100:+","gi|11560073|ref|NP_071595.1|",1625,0,"natural killer cell receptor 2B4 precursor [Rattus norvegicus]","gi|11560072|ref|NM_022259.1|",1346,0,"Rattus norvegicus CD244 molecule (Cd244), mRNA","Q9JLM2",630,0,"Natural killer cell receptor 2B4",".",".",".",".","pfam11465","Receptor_2B4","Natural killer cell receptor 2B4. 2B4 is a transmembrane receptor which is expressed primarily on natural killer cells. It plays a role in activating NK-mediated cytotoxicity through its interaction with CD48 on target cells in a subset of CD8 T cells. The structure of 2B4 consists of an immunoglobulin variable domain fold and contains two beta-sheets. One of the beta-sheets, the six-stranded sheet, contains structural features that may have a role in ligand recognition and receptor function.",".",".",".",".","."]
["ENSRNOG00000068167",52,4.317386347,31,1.994243584,2.164924276,1.114316564,0.000511339,0.000532414,"up","yes","ENSRNOG00000068167","lncRNA","chr4:181911455-181913982:+","gi|26345134|dbj|BAC36216.1|",453,{"v":2E-70,"d":"2.00E-70"},"unnamed protein product [Mus musculus]","gi|52077875|gb|AC140327.3|",1496,0,"Mus musculus BAC clone RP24-325P20 from 6, complete sequence",".",".",".",".",".",".",".",".","pfam15483","DUF4641","Domain of unknown function (DUF4641). This family of proteins is found in eukaryotes. Proteins in this family are typically between 201 and 519 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000001128",45,3.736199724,25,1.608260955,2.323130281,1.216070063,0.000528402,0.000549196,"up","yes","Tesc","protein_coding","chr12:38521861-38555824:-","gi|31981125|ref|NP_067319.2|",997,{"v":5e-130,"d":"5.00E-130"},"calcineurin B homologous protein 3 [Mus musculus]","gi|672073221|ref|XM_213790.9|",685,0,"PREDICTED: Rattus norvegicus tescalcin (Tesc), transcript variant X3, mRNA","Q9JKL5",388,{"v":2E-131,"d":"2.00E-131"},"Calcineurin B homologous protein 3","YKL190w",60.8,{"v":6E-10,"d":"6.00E-10"},"COG5126","pfam13405","EF-hand_6","EF-hand domain.","GO:0008285|negative regulation of cell proliferation;GO:0008584|male gonad development;GO:0010628|positive regulation of gene expression;GO:0030219|megakaryocyte differentiation;GO:0030854|positive regulation of granulocyte differentiation;GO:0032417|positive regulation of sodium:proton antiporter activity;GO:0033628|regulation of cell adhesion mediated by integrin;GO:0043086|negative regulation of catalytic activity;GO:0045654|positive regulation of megakaryocyte differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0050821|protein stabilization;GO:0051604|protein maturation;GO:0071300|cellular response to retinoic acid;GO:0072659|protein localization to plasma membrane;","GO:0001726|ruffle;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0030027|lamellipodium;","GO:0000287|magnesium ion binding;GO:0005509|calcium ion binding;GO:0019212|phosphatase inhibitor activity;GO:0042803|protein homodimerization activity;","K17612","TESC, CHP3; calcineurin B homologous protein 3"]
["ENSRNOG00000025332",39,3.23803976,20,1.286608764,2.516724471,1.33154728,0.000534178,0.000554624,"up","yes","Cd109","protein_coding","chr8:79454480-79569194:+","gi|392342020|ref|XP_003754487.1|",7420,0,"PREDICTED: CD109 antigen [Rattus norvegicus]","gi|672062623|ref|XM_003750546.3|",4973,0,"PREDICTED: Rattus norvegicus CD109 molecule (Cd109), mRNA","Q8R422",2328,0,"CD109 antigen",".",".",".",".","pfam07678","A2M_comp","A-macroglobulin complement component. This family includes the complement components region of the alpha-2-macroglobulin family.","GO:0001933|negative regulation of protein phosphorylation;GO:0001942|hair follicle development;GO:0010839|negative regulation of keratinocyte proliferation;GO:0010951|negative regulation of endopeptidase activity;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0045616|regulation of keratinocyte differentiation;GO:0061045|negative regulation of wound healing;GO:0072675|osteoclast fusion;","GO:0005615|extracellular space;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0004867|serine-type endopeptidase inhibitor activity;GO:0050431|transforming growth factor beta binding;","K06530","CD109; CD109 antigen"]
["ENSRNOG00000069732",39,3.23803976,20,1.286608764,2.516724471,1.33154728,0.000534178,0.000554624,"up","yes","ENSRNOG00000069732","lncRNA","chr7:130056833-130058256:-","gi|148692777|gb|EDL24724.1|",138,2e-07,"interleukin 17 receptor D [Mus musculus]","gi|37202204|gb|AC115751.6|",87,{"v":2E-35,"d":"2.00E-35"},"Mus musculus chromosome 1, clone RP23-16I21, complete sequence",".",".",".",".",".",".",".",".","pfam00517","GP41","Retroviral envelope protein. This family includes envelope protein from a variety of retroviruses. It includes the GP41 subunit of the envelope protein complex from human and simian immunodeficiency viruses (HIV and SIV) which mediate membrane fusion during viral entry. The family also includes bovine immunodeficiency virus, feline immunodeficiency virus and Equine infectious anaemia (EIAV). The family also includes the Gp36 protein from mouse mammary tumor virus (MMTV) and human endogenous retroviruses (HERVs).",".",".",".",".","."]
["ENSRNOG00000006311",10,0.830266605,0,0.032165219,25.81255868,4.690001251,0.000557807,0.000577038,"up","yes","Ccr9","protein_coding","chr8:123395813-123413969:+","gi|27229230|ref|NP_758832.1|",1756,0,"C-C chemokine receptor type 9 [Rattus norvegicus]","gi|60551362|gb|BC091115.1|",2472,0,"Rattus norvegicus chemokine (C-C motif) receptor 9, mRNA (cDNA clone MGC:108562 IMAGE:7381553), complete cds","Q9WUT7",674,0,"C-C chemokine receptor type 9",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0002305|CD8-positive, gamma-delta intraepithelial T cell differentiation;GO:0006935|chemotaxis;GO:0006955|immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0019722|calcium-mediated signaling;GO:0060326|cell chemotaxis;GO:0070098|chemokine-mediated signaling pathway;","GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0016493|C-C chemokine receptor activity;GO:0019957|C-C chemokine binding;","K04184","CCR9, CDw199; C-C chemokine receptor type 9"]
["ENSRNOG00000032737",10,0.830266605,0,0.032165219,25.81255868,4.690001251,0.000557807,0.000577038,"up","yes","F7","protein_coding","chr16:76489717-76500610:-","gi|25742855|ref|NP_690059.1|",2213,0,"coagulation factor VII precursor [Rattus norvegicus]","gi|25742854|ref|NM_152846.1|",1341,0,"Rattus norvegicus coagulation factor VII (F7), mRNA","Q8K3U6",855,0,"Coagulation factor VII","mlr3307",101,{"v":2e-22,"d":"2.00E-22"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0001666|response to hypoxia;GO:0002690|positive regulation of leukocyte chemotaxis;GO:0007596|blood coagulation;GO:0007623|circadian rhythm;GO:0009725|response to hormone;GO:0010037|response to carbon dioxide;GO:0010641|positive regulation of platelet-derived growth factor receptor signaling pathway;GO:0014070|response to organic cyclic compound;GO:0016485|protein processing;GO:0030194|positive regulation of blood coagulation;GO:0031100|animal organ regeneration;GO:0031667|response to nutrient levels;GO:0032355|response to estradiol;GO:0032571|response to vitamin K;GO:0033595|response to genistein;GO:0043627|response to estrogen;GO:0050927|positive regulation of positive chemotaxis;GO:0051897|positive regulation of protein kinase B signaling;GO:0060416|response to growth hormone;GO:0061476|response to anticoagulant;GO:0070723|response to cholesterol;GO:0097066|response to thyroid hormone;GO:0097068|response to thyroxine;GO:1904400|response to Thyroid stimulating hormone;GO:1904612|response to 2,3,7,8-tetrachlorodibenzodioxine;GO:1905217|response to astaxanthin;GO:1905225|response to thyrotropin-releasing hormone;","GO:0005615|extracellular space;GO:0031982|vesicle;GO:1905286|serine-type peptidase complex;","GO:0004175|endopeptidase activity;GO:0004252|serine-type endopeptidase activity;GO:0005102|signaling receptor binding;GO:0005509|calcium ion binding;","K01320","F7; coagulation factor VII [EC:3.4.21.21]"]
["ENSRNOG00000064495",10,0.830266605,0,0.032165219,25.81255868,4.690001251,0.000557807,0.000577038,"up","yes","ENSRNOG00000064495","lncRNA","chr19:52912680-52915635:+","gi|149036607|gb|EDL91225.1|",229,{"v":2E-19,"d":"2.00E-19"},"rCG56442 [Rattus norvegicus]","gi|111038150|gb|AC132998.5|",164,{"v":4E-78,"d":"4.00E-78"},"Rattus norvegicus BAC CH230-6L10 () complete sequence","P46935",54.3,3e-06,"E3 ubiquitin-protein ligase NEDD4",".",".",".",".",".",".",".",".",".",".",".","."]
["ENSRNOG00000065916",10,0.830266605,0,0.032165219,25.81255868,4.690001251,0.000557807,0.000577038,"up","yes","ENSRNOG00000065916","lncRNA","chr3:147154097-147160490:+","gi|293358231|ref|XP_002729292.1|",411,{"v":7e-47,"d":"7.00E-47"},"PREDICTED: adipogenin-like [Rattus norvegicus]","gi|672047855|ref|XM_002729246.3|",663,0,"PREDICTED: Rattus norvegicus adipogenin (Adig), mRNA","Q8R400",139,{"v":2e-39,"d":"2.00E-39"},"Adipogenin",".",".",".",".","pfam15202","Adipogenin","Adipogenin. This family of proteins is involved in the stimulation of adipocyte differentiation and development.",".",".",".",".","."]
["ENSRNOG00000069373",10,0.830266605,0,0.032165219,25.81255868,4.690001251,0.000557807,0.000577038,"up","yes","Hist1h2bc","protein_coding","chr17:42694723-42696642:-","gi|821141378|ref|XP_012376417.1|",466,{"v":2e-56,"d":"2.00E-56"},"PREDICTED: histone H2B type 1-K-like [Dasypus novemcinctus]","gi|672082124|ref|XM_008771769.1|",441,0,"PREDICTED: Rattus norvegicus histone cluster 1, H2bc-like 1 (Hist1h2bcl1), mRNA","Q99877",183,{"v":8e-58,"d":"8.00E-58"},"Histone H2B type 1-N",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.",".",".",".",".","."]
["ENSRNOG00000017539",46,3.819226384,26,1.672591393,2.283418652,1.191195394,0.000566057,5.85006E-4,"up","yes","Mmp9","protein_coding","chr3:153683858-153692120:+","gi|149042905|gb|EDL96479.1|",3390,0,"matrix metallopeptidase 9 [Rattus norvegicus]","gi|13591992|ref|NM_031055.1|",2975,0,"Rattus norvegicus matrix metallopeptidase 9 (Mmp9), mRNA","P50282",1275,0,"Matrix metalloproteinase-9",".",".",".",".","pfam00413","Peptidase_M10","Matrixin. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.","GO:0001501|skeletal system development;GO:0001503|ossification;GO:0001666|response to hypoxia;GO:0001822|kidney development;GO:0001934|positive regulation of protein phosphorylation;GO:0002687|positive regulation of leukocyte migration;GO:0006508|proteolysis;GO:0006979|response to oxidative stress;GO:0007507|heart development;GO:0007566|embryo implantation;GO:0007567|parturition;GO:0007568|aging;GO:0007584|response to nutrient;GO:0009314|response to radiation;GO:0009408|response to heat;GO:0009410|response to xenobiotic stimulus;GO:0009612|response to mechanical stimulus;GO:0009644|response to high light intensity;GO:0010033|response to organic substance;GO:0014070|response to organic cyclic compound;GO:0019087|transformation of host cell by virus;GO:0030198|extracellular matrix organization;GO:0030335|positive regulation of cell migration;GO:0030574|collagen catabolic process;GO:0031915|positive regulation of synaptic plasticity;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0032526|response to retinoic acid;GO:0033189|response to vitamin A;GO:0034612|response to tumor necrosis factor;GO:0034614|cellular response to reactive oxygen species;GO:0035094|response to nicotine;GO:0035987|endodermal cell differentiation;GO:0043065|positive regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0043388|positive regulation of DNA binding;GO:0045471|response to ethanol;GO:0045742|positive regulation of epidermal growth factor receptor signaling pathway;GO:0045766|positive regulation of angiogenesis;GO:0048147|negative regulation of fibroblast proliferation;GO:0048771|tissue remodeling;GO:0050900|leukocyte migration;GO:0051549|positive regulation of keratinocyte migration;GO:0055093|response to hyperoxia;GO:0071222|cellular response to lipopolysaccharide;GO:0071276|cellular response to cadmium ion;GO:0071283|cellular response to iron(III) ion;GO:0071345|cellular response to cytokine stimulus;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071404|cellular response to low-density lipoprotein particle stimulus;GO:0071460|cellular response to cell-matrix adhesion;GO:0071492|cellular response to UV-A;GO:0090200|positive regulation of release of cytochrome c from mitochondria;GO:1900122|positive regulation of receptor binding;GO:1904645|response to amyloid-beta;GO:1904707|positive regulation of vascular smooth muscle cell proliferation;GO:2000697|negative regulation of epithelial cell differentiation involved in kidney development;GO:2001243|negative regulation of intrinsic apoptotic signaling pathway;GO:2001258|negative regulation of cation channel activity;GO:2001268|negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0031012|extracellular matrix;GO:0032991|protein-containing complex;","GO:0001968|fibronectin binding;GO:0004175|endopeptidase activity;GO:0004222|metalloendopeptidase activity;GO:0004252|serine-type endopeptidase activity;GO:0005515|protein binding;GO:0008233|peptidase activity;GO:0008237|metallopeptidase activity;GO:0008270|zinc ion binding;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;","K01403","MMP9; matrix metalloproteinase-9 (gelatinase B) [EC:3.4.24.35]"]
["ENSRNOG00000007037",30,2.490799816,13,0.836295696,2.978372155,1.574524034,5.74436E-4,0.00059242,"up","yes","Cfap57","protein_coding","chr5:132074395-132148462:-","gi|672053932|ref|XP_008762314.1|",6472,0,"PREDICTED: WD repeat-containing protein 65 isoform X2 [Rattus norvegicus]","gi|672053931|ref|XM_008764092.1|",3991,0,"PREDICTED: Rattus norvegicus similar to CG4329-PA, isoform A (LOC679641), transcript variant X2, mRNA",".",".",".",".","all0664",92,{"v":7e-18,"d":"7.00E-18"},"COG2319","pfam10174","Cast","RIM-binding protein of the cytomatrix active zone. This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.",".",".",".","K24729","CFAP57, WDR65; cilia- and flagella-associated protein 57"]
["ENSRNOG00000071079",30,2.490799816,13,0.836295696,2.978372155,1.574524034,5.74436E-4,0.00059242,"up","yes","ENSRNOG00000071079","lncRNA","chr8:79290513-79292772:+","gi|432101292|gb|ELK29518.1|",101,2e-06,"hypothetical protein MDA_GLEAN10005688 [Myotis davidii]","gi|74222279|dbj|AK146160.1|",115,{"v":3E-51,"d":"3.00E-51"},"Mus musculus TIB-55 BB88 cDNA, RIKEN full-length enriched library, clone:I730025B03 product:unclassifiable, full insert sequence","Q3UTZ3",43.9,7e-08,"Uncharacterized protein C7orf43 homolog",".",".",".",".","pfam03616","Glt_symporter","Sodium/glutamate symporter.",".",".",".",".","."]
["ENSRNOG00000011000",11,0.913293266,1,0.064330438,14.19690727,3.827504775,0.000602838,0.000618916,"up","yes","Rims1","protein_coding","chr9:24698854-25196631:-","gi|148682448|gb|EDL14395.1|",6050,0,"regulating synaptic membrane exocytosis 1 [Mus musculus]","gi|672064620|ref|XM_008766936.1|",2796,0,"PREDICTED: Rattus norvegicus regulating synaptic membrane exocytosis 1 (Rims1), transcript variant X1, mRNA","Q9JIR4",1744,0,"Regulating synaptic membrane exocytosis protein 1",".",".",".",".","pfam00168","C2","C2 domain.","GO:0006836|neurotransmitter transport;GO:0006886|intracellular protein transport;GO:0006887|exocytosis;GO:0007269|neurotransmitter secretion;GO:0010628|positive regulation of gene expression;GO:0010808|positive regulation of synaptic vesicle priming;GO:0016081|synaptic vesicle docking;GO:0016082|synaptic vesicle priming;GO:0030154|cell differentiation;GO:0031632|positive regulation of synaptic vesicle fusion to presynaptic active zone membrane;GO:0042391|regulation of membrane potential;GO:0048167|regulation of synaptic plasticity;GO:0048169|regulation of long-term neuronal synaptic plasticity;GO:0048790|maintenance of presynaptic active zone structure;GO:0048791|calcium ion-regulated exocytosis of neurotransmitter;GO:0050806|positive regulation of synaptic transmission;GO:0060291|long-term synaptic potentiation;GO:0060478|acrosomal vesicle exocytosis;GO:0061669|spontaneous neurotransmitter secretion;GO:0065003|protein-containing complex assembly;GO:0097151|positive regulation of inhibitory postsynaptic potential;GO:1903861|positive regulation of dendrite extension;GO:2000463|positive regulation of excitatory postsynaptic potential;","GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0031982|vesicle;GO:0042734|presynaptic membrane;GO:0042995|cell projection;GO:0045202|synapse;GO:0048788|cytoskeleton of presynaptic active zone;GO:0060077|inhibitory synapse;GO:0098831|presynaptic active zone cytoplasmic component;GO:0098978|glutamatergic synapse;GO:0098982|GABA-ergic synapse;","GO:0005515|protein binding;GO:0017124|SH3 domain binding;GO:0019901|protein kinase binding;GO:0031267|small GTPase binding;GO:0044325|ion channel binding;GO:0046872|metal ion binding;GO:0098882|structural constituent of presynaptic active zone;","K15291","RIMS1, RIM1; regulating synaptic membrane exocytosis protein 1"]
["ENSRNOG00000017842",11,0.913293266,1,0.064330438,14.19690727,3.827504775,0.000602838,0.000618916,"up","yes","Scnn1g","protein_coding","chr1:176304942-176338816:+","gi|149068028|gb|EDM17580.1|",3317,0,"sodium channel, nonvoltage-gated 1 gamma [Rattus norvegicus]","gi|25742789|ref|NM_017046.1|",2936,0,"Rattus norvegicus sodium channel epithelial 1 gamma subunit (Scnn1g), mRNA","P37091",1280,0,"Amiloride-sensitive sodium channel subunit gamma",".",".",".",".","pfam00858","ASC","Amiloride-sensitive sodium channel.","GO:0001666|response to hypoxia;GO:0006814|sodium ion transport;GO:0035313|wound healing, spreading of epidermal cells;GO:0035725|sodium ion transmembrane transport;GO:0050891|multicellular organismal water homeostasis;GO:0050909|sensory perception of taste;GO:0055078|sodium ion homeostasis;GO:1904045|cellular response to aldosterone;","GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0034706|sodium channel complex;GO:0070062|extracellular exosome;GO:0098797|plasma membrane protein complex;","GO:0005216|ion channel activity;GO:0005272|sodium channel activity;GO:0005515|protein binding;GO:0015081|sodium ion transmembrane transporter activity;GO:0015280|ligand-gated sodium channel activity;GO:0050699|WW domain binding;","K04827","SCNN1G, ENACG; amiloride-sensitive sodium channel subunit gamma"]
["ENSRNOG00000019022",11,0.913293266,1,0.064330438,14.19690727,3.827504775,0.000602838,0.000618916,"up","yes","Fam89a","protein_coding","chr19:52710019-52722631:-","gi|58743349|ref|NP_001011711.1|",569,{"v":2e-67,"d":"2.00E-67"},"protein FAM89A [Rattus norvegicus]","gi|79152851|gb|BC107921.1|",1370,0,"Rattus norvegicus family with sequence similarity 89, member A, mRNA (cDNA clone MGC:124908 IMAGE:7445343), complete cds",".",".",".",".",".",".",".",".","pfam07816","DUF1645","Protein of unknown function (DUF1645). These sequences are derived from a number of hypothetical plant proteins. The region in question is approximately 270 amino acids long. Some members of this family are annotated as yeast pheromone receptor proteins AR781 but no literature was found to support this.",".",".",".",".","."]
["ENSRNOG00000020625",11,0.913293266,1,0.064330438,14.19690727,3.827504775,0.000602838,0.000618916,"up","yes","ENSRNOG00000020625","protein_coding","chr15:29871335-29873926:+","gi|25282393|ref|NP_742041.1|",1197,{"v":9e-163,"d":"9.00E-163"},"mast cell protease 2 precursor [Rattus norvegicus]","gi|25282392|ref|NM_172044.1|",741,0,"Rattus norvegicus mast cell protease 2 (Mcpt2), mRNA","P00770",465,{"v":3e-164,"d":"3.00E-164"},"Mast cell protease 2","mlr3307",72.8,{"v":1E-13,"d":"1.00E-13"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;","GO:0005615|extracellular space;","GO:0004252|serine-type endopeptidase activity;","K08662","MCPT2; mast cell peptidase 2 [EC:3.4.21.-]"]
["ENSRNOG00000064334",11,0.913293266,1,0.064330438,14.19690727,3.827504775,0.000602838,0.000618916,"up","yes","ENSRNOG00000064334","protein_coding","chr20:3429049-3430989:-","gi|2305226|gb|AAB65752.1|",304,{"v":7e-33,"d":"7.00E-33"},"oral tumor suppressor homolog [Mus musculus]","gi|676260331|ref|NG_004606.5|",329,{"v":1e-170,"d":"1.00E-170"},"Rattus norvegicus Cdk2ap1-ps4 pseudogene (Cdk2ap1-ps4) on chromosome 20","O35207",121,{"v":2e-34,"d":"2.00E-34"},"Cyclin-dependent kinase 2-associated protein 1",".",".",".",".","pfam09806","CDK2AP","Cyclin-dependent kinase 2-associated protein. Members of this family of proteins are cell-growth suppressors, associating with and influencing the biological activities of important cell cycle regulators in the S phase including monomeric non-phosphorylated cyclin-dependent kinase 2 (CDK2) and DNA polymerase alpha/primase. An association between mutations in the gene coding for this protein and oral cancer has been described.",".",".",".",".","."]
["ENSRNOG00000065655",11,0.913293266,1,0.064330438,14.19690727,3.827504775,0.000602838,0.000618916,"up","yes","ENSRNOG00000065655","protein_coding","chr3:159654904-159657981:-","gi|672059154|ref|XP_008763709.1|",3129,0,"PREDICTED: MLV-related proviral Env polyprotein-like [Rattus norvegicus]","gi|672081238|ref|XM_008771515.1|",1926,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102556474 (LOC102556474), mRNA","P21415",478,{"v":1e-157,"d":"1.00E-157"},"Envelope glycoprotein",".",".",".",".","pfam00429","TLV_coat","ENV polyprotein (coat polyprotein).",".",".",".",".","."]
["ENSRNOG00000071073",11,0.913293266,1,0.064330438,14.19690727,3.827504775,0.000602838,0.000618916,"up","yes","Sost","protein_coding","chr10:86911517-86915561:-","gi|13399334|ref|NP_085073.1|",1027,{"v":3E-134,"d":"3.00E-134"},"sclerostin precursor [Rattus norvegicus]","gi|567316044|ref|NM_024449.6|",936,0,"Mus musculus sclerostin (Sost), mRNA","Q99P67",400,{"v":1E-135,"d":"1.00E-135"},"Sclerostin",".",".",".",".","pfam05463","Sclerostin","Sclerostin (SOST). This family contains several mammalian sclerostin (SOST) proteins. SOST is thought to suppress bone formation. Mutations of the SOST gene lead to sclerosteosis, a progressive sclerosing bone dysplasia with an autosomal recessive mode of inheritance. Radiologically, it is characterized by a generalised hyperostosis and sclerosis leading to a markedly thickened and sclerotic skull, with mandible, ribs, clavicles and all long bones also being affected. Due to narrowing of the foramina of the cranial nerves, facial nerve palsy, hearing loss and atrophy of the optic nerves can occur. Sclerosteosis is clinically and radiologically very similar to van Buchem disease, mainly differentiated by hand malformations and a large stature in sclerosteosis patients.",".",".",".",".","."]
["ENSRNOG00000002459",20,1.66053321,6,0.385982629,4.302093113,2.10503875,0.000606505,0.000622481,"up","yes","Fbxo40","protein_coding","chr11:63794624-63812697:+","gi|392352074|ref|XP_344024.5|",3649,0,"PREDICTED: F-box only protein 40 [Rattus norvegicus]","gi|298888829|emb|FQ223618.1|",3803,0,"Rattus norvegicus TL0ACA91YC22 mRNA sequence","P62932",1321,0,"F-box only protein 40",".",".",".",".","pfam02176","zf-TRAF","TRAF-type zinc finger.","GO:0016567|protein ubiquitination;GO:0042692|muscle cell differentiation;","GO:0005737|cytoplasm;","GO:0008270|zinc ion binding;GO:0061630|ubiquitin protein ligase activity;","K10315","FBXO40; F-box protein 40"]
["ENSRNOG00000046155",20,1.66053321,6,0.385982629,4.302093113,2.10503875,0.000606505,0.000622481,"up","yes","ENSRNOG00000046155","protein_coding","chr8:109036030-109097895:+","gi|202070754|ref|NP_001128484.1|",4968,0,"ubiquitin carboxyl-terminal hydrolase 4 isoform a [Rattus norvegicus]","gi|202070753|ref|NM_001135012.1|",3886,0,"Rattus norvegicus ubiquitin specific peptidase 4 (proto-oncogene) (Usp4), transcript variant 1, mRNA","B2GUZ1",1918,0,"Ubiquitin carboxyl-terminal hydrolase 4","SPCC1494.05c",249,{"v":7e-67,"d":"7.00E-67"},"COG5560","pfam00443","UCH","Ubiquitin carboxyl-terminal hydrolase.",".",".",".",".","."]
["ENSRNOG00000039955",13,1.079346587,2,0.128660876,8.389081571,3.068512874,0.000649826,0.000663747,"up","yes","Samd3","protein_coding","chr1:19103036-19148192:-","gi|285403624|ref|NP_001165587.1|",1469,0,"sterile alpha motif domain-containing protein 3 [Rattus norvegicus]","gi|285403623|ref|NM_001172116.1|",822,0,"Rattus norvegicus sterile alpha motif domain containing 3 (Samd3), mRNA",".",".",".",".",".",".",".",".","pfam00536","SAM_1","SAM domain (Sterile alpha motif). It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.",".",".",".",".","."]
["ENSRNOG00000068909",13,1.079346587,2,0.128660876,8.389081571,3.068512874,0.000649826,0.000663747,"up","yes","Cyp11b1","protein_coding","chr7:106718274-106779278:-","gi|303794|dbj|BAA00988.1|",2467,0,"cytochrome P-450-11beta [Rattus norvegicus]","gi|672059626|ref|XM_003750363.3|",1514,0,"PREDICTED: Rattus norvegicus cytochrome P450 11B1, mitochondrial-like (LOC100910462), transcript variant X1, mRNA","P15393",950,0,"Cytochrome P450 11B1, mitochondrial","alr4833",86.7,{"v":8e-17,"d":"8.00E-17"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.",".",".",".",".","."]
["ENSRNOG00000047124",31,2.573826476,14,0.900626135,2.857818997,1.514914545,0.000667049,0.000679602,"up","yes","AABR07005775.1","protein_coding","chr1:181026608-181044838:-","gi|675707375|ref|XP_009007677.1|",4406,0,"PREDICTED: sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [Callithrix jacchus]","gi|17157986|ref|NM_058213.1|",2004,0,"Rattus norvegicus ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 (Atp2a1), mRNA","Q64578",1067,0,"Sarcoplasmic/endoplasmic reticulum calcium ATPase 1","CAC2137",310,{"v":8e-89,"d":"8.00E-89"},"COG0474","pfam00122","E1-E2_ATPase","E1-E2 ATPase.",".",".",".",".","."]
["ENSRNOG00000025460",27,2.241719834,11,0.70763482,3.167904929,1.66352904,0.000677468,0.000689668,"up","yes","Tmem71","protein_coding","chr7:98276975-98315858:-","gi|403420582|ref|NP_001258144.1|",1268,{"v":1E-165,"d":"1.00E-165"},"transmembrane protein 71 [Rattus norvegicus]","gi|403420581|ref|NM_001271215.1|",1206,0,"Rattus norvegicus transmembrane protein 71 (Tmem71), mRNA","Q149F5",449,{"v":3e-150,"d":"3.00E-150"},"Transmembrane protein 71",".",".",".",".","pfam15121","TMEM71","TMEM71 protein family. The function of this family, TMEM71, is not known, however it is predicted to be a transmembrane protein. This family of proteins is found in eukaryotes and located in the cell membrane. Proteins in this family vary between 41 and 291 amino acids in length.",".","GO:0005739|mitochondrion;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000008798",36,2.988959779,18,1.157947887,2.581255868,1.368073156,0.000681671,0.000693725,"up","yes","Pipox","protein_coding","chr10:62769900-62782370:-","gi|58865586|ref|NP_001012009.1|",2097,0,"peroxisomal sarcosine oxidase [Rattus norvegicus]","gi|564373368|ref|XM_006246958.1|",1666,0,"PREDICTED: Rattus norvegicus pipecolic acid oxidase (Pipox), transcript variant X1, mRNA","Q9D826",756,0,"Peroxisomal sarcosine oxidase","STM1160",171,{"v":2E-46,"d":"2.00E-46"},"COG0665","pfam01266","DAO","FAD dependent oxidoreductase. This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.","GO:0033514|L-lysine catabolic process to acetyl-CoA via L-pipecolate;GO:0046653|tetrahydrofolate metabolic process;","GO:0005777|peroxisome;","GO:0008115|sarcosine oxidase activity;GO:0050031|L-pipecolate oxidase activity;","K00306","PIPOX; sarcosine oxidase / L-pipecolate oxidase [EC:1.5.3.1 1.5.3.7]"]
["ENSRNOG00000018268",43,3.570146403,24,1.543930516,2.312375048,1.20937541,0.000742749,0.000750627,"up","yes","Hhip","protein_coding","chr19:27863213-27952528:+","gi|300797038|ref|NP_001178746.1|",3583,0,"hedgehog-interacting protein precursor [Rattus norvegicus]","gi|300797037|ref|NM_001191817.1|",2542,0,"Rattus norvegicus Hedgehog-interacting protein (Hhip), mRNA","Q7TN16",1331,0,"Hedgehog-interacting protein","SMb20301",63.5,1e-09,"COG2133","pfam03024","Folate_rec","Folate receptor family. This family includes the folate receptor which binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. These proteins are attached to the membrane by a GPI-anchor. The proteins contain 16 conserved cysteines that form eight disulphide bridges.","GO:0007165|signal transduction;GO:0007405|neuroblast proliferation;GO:0009887|animal organ morphogenesis;GO:0009953|dorsal/ventral pattern formation;GO:0009968|negative regulation of signal transduction;GO:0040036|regulation of fibroblast growth factor receptor signaling pathway;GO:0043066|negative regulation of apoptotic process;GO:0045879|negative regulation of smoothened signaling pathway;GO:0048705|skeletal system morphogenesis;GO:0060441|epithelial tube branching involved in lung morphogenesis;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;","GO:0003674|molecular_function;GO:0003824|catalytic activity;GO:0008270|zinc ion binding;GO:0097108|hedgehog family protein binding;","K06231","HHIP; hedgehog interacting protein"]
["ENSRNOG00000018827",43,3.570146403,24,1.543930516,2.312375048,1.20937541,0.000742749,0.000750627,"up","yes","Htr7","protein_coding","chr1:233636452-233760626:-","gi|564333544|ref|XP_006231369.1|",2234,0,"PREDICTED: 5-hydroxytryptamine receptor 7 isoform X1 [Rattus norvegicus]","gi|74226455|dbj|AK139197.1|",2505,0,"Mus musculus 7 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:A730064F17 product:5-hydroxytryptamine (serotonin) receptor 7, full insert sequence","P32305",863,0,"5-hydroxytryptamine receptor 7",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0006939|smooth muscle contraction;GO:0007187|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007192|adenylate cyclase-activating serotonin receptor signaling pathway;GO:0007210|serotonin receptor signaling pathway;GO:0007268|chemical synaptic transmission;GO:0007613|memory;GO:0007623|circadian rhythm;GO:0010976|positive regulation of neuron projection development;GO:0014063|negative regulation of serotonin secretion;GO:0014832|urinary bladder smooth muscle contraction;GO:0042310|vasoconstriction;GO:0042322|negative regulation of circadian sleep/wake cycle, REM sleep;GO:0048266|behavioral response to pain;GO:0050966|detection of mechanical stimulus involved in sensory perception of pain;GO:0051412|response to corticosterone;GO:0051602|response to electrical stimulus;GO:0060073|micturition;GO:0060291|long-term synaptic potentiation;GO:0071542|dopaminergic neuron differentiation;GO:0098664|G protein-coupled serotonin receptor signaling pathway;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0005791|rough endoplasmic reticulum;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0008021|synaptic vesicle;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0043025|neuronal cell body;GO:0043679|axon terminus;GO:0045202|synapse;GO:0099055|integral component of postsynaptic membrane;GO:0099056|integral component of presynaptic membrane;","GO:0004993|G protein-coupled serotonin receptor activity;GO:0030594|neurotransmitter receptor activity;","K04163","HTR7; 5-hydroxytryptamine receptor 7"]
["ENSRNOG00000021063",43,3.570146403,24,1.543930516,2.312375048,1.20937541,0.000742749,0.000750627,"up","yes","Grin2d","protein_coding","chr1:96308365-96344793:-","gi|672036277|ref|XP_008757538.1|",5040,0,"PREDICTED: glutamate receptor ionotropic, NMDA 2D isoform X1 [Rattus norvegicus]","gi|12248180|ref|NM_022797.1|",5211,0,"Rattus norvegicus glutamate ionotropic receptor NMDA type subunit 2D (Grin2d), mRNA","Q62645",1945,0,"Glutamate receptor ionotropic, NMDA 2D",".",".",".",".","pfam00060","Lig_chan","Ligand-gated ion channel. This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.","GO:0001964|startle response;GO:0008344|adult locomotory behavior;GO:0019722|calcium-mediated signaling;GO:0035235|ionotropic glutamate receptor signaling pathway;GO:0035249|synaptic transmission, glutamatergic;GO:0051930|regulation of sensory perception of pain;GO:0060079|excitatory postsynaptic potential;GO:0060291|long-term synaptic potentiation;GO:0097553|calcium ion transmembrane import into cytosol;","GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0008328|ionotropic glutamate receptor complex;GO:0017146|NMDA selective glutamate receptor complex;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0098686|hippocampal mossy fiber to CA3 synapse;GO:0098839|postsynaptic density membrane;GO:0098978|glutamatergic synapse;GO:0099061|integral component of postsynaptic density membrane;","GO:0004970|ionotropic glutamate receptor activity;GO:0004972|NMDA glutamate receptor activity;GO:0005261|cation channel activity;GO:0005515|protein binding;GO:0015276|ligand-gated ion channel activity;GO:0016595|glutamate binding;GO:0022843|voltage-gated cation channel activity;GO:0022849|glutamate-gated calcium ion channel activity;GO:0038023|signaling receptor activity;GO:0042165|neurotransmitter binding;GO:1904315|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K05212","GRIN2D; glutamate receptor ionotropic, NMDA 2D"]
["ENSRNOG00000042747",24,1.992639853,9,0.578973944,3.441674491,1.783110655,7.68033E-4,0.000774343,"up","yes","Fam72a","protein_coding","chr13:42967578-42984208:+","gi|149058670|gb|EDM09827.1|",716,{"v":1E-89,"d":"1.00E-89"},"rCG45940 [Rattus norvegicus]","gi|1001624570|ref|NM_175382.4|",987,0,"Mus musculus family with sequence similarity 72, member A (Fam72a), mRNA","A1KXW8",277,{"v":7e-90,"d":"7.00E-90"},"Protein FAM72A",".",".",".",".","pfam14976","FAM72","FAM72 protein. This family of proteins is found in eukaryotes. Proteins in this family are typically between 145 and 264 amino acids in length. The function of this family is unknown.","GO:0031552|negative regulation of brain-derived neurotrophic factor-activated receptor activity;GO:0043065|positive regulation of apoptotic process;","GO:0005739|mitochondrion;GO:0005829|cytosol;GO:0016020|membrane;GO:0043231|intracellular membrane-bounded organelle;",".",".","."]
["ENSRNOG00000008625",18,1.494479889,5,0.321652191,4.646260562,2.216070063,0.000782103,0.000787039,"up","yes","Rimkla","protein_coding","chr5:133073960-133098792:-","gi|149035428|gb|EDL90109.1|",1910,0,"rCG50366 [Rattus norvegicus]","gi|672019878|ref|XR_146988.3|",2284,0,"PREDICTED: Rattus norvegicus ribosomal modification protein rimK-like family member A (Rimkla), misc_RNA","Q6PFX8",727,0,"N-acetylaspartylglutamate synthase A","MA1361",120,{"v":8e-29,"d":"8.00E-29"},"COG0189","pfam08443","RimK","RimK-like ATP-grasp domain. This ATP-grasp domain is found in the ribosomal S6 modification enzyme RimK.","GO:0006464|cellular protein modification process;","GO:0005737|cytoplasm;","GO:0005524|ATP binding;GO:0046872|metal ion binding;GO:0072590|N-acetyl-L-aspartate-L-glutamate ligase activity;",".","."]
["ENSRNOG00000016921",52,4.317386347,32,2.058574022,2.097270393,1.068512874,0.000783758,7.88457E-4,"up","yes","Klhl11","protein_coding","chr10:85398487-85409049:-","gi|157786686|ref|NP_001099308.1|",3766,0,"kelch-like protein 11 [Rattus norvegicus]","gi|157786685|ref|NM_001105838.1|",2441,0,"Rattus norvegicus kelch-like family member 11 (Klhl11), mRNA","Q8CE33",1451,0,"Kelch-like protein 11",".",".",".",".","pfam07707","BACK","BTB And C-terminal Kelch. This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).",".",".",".","K10449","KLHL11; kelch-like protein 11"]
["ENSRNOG00000053325",52,4.317386347,32,2.058574022,2.097270393,1.068512874,0.000783758,7.88457E-4,"up","yes","AABR07009105.1","protein_coding","chr2:84562574-84591269:+","gi|47564121|ref|NP_001001152.1|",1620,0,"zinc finger protein 728 [Mus musculus]","gi|298881396|emb|FQ217081.1|",2051,0,"Rattus norvegicus TL0ACA36YA15 mRNA sequence","Q6P5C7",628,0,"Zinc finger protein 728",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000067247",38,3.1550131,20,1.286608764,2.452193075,1.294072575,0.000826516,0.000827918,"up","yes","ENSRNOG00000067247","lncRNA","chr12:6158872-6163108:-",".",".",".",".","gi|672026470|ref|XR_590010.1|",300,{"v":4e-154,"d":"4.00E-154"},"PREDICTED: Rattus norvegicus uncharacterized LOC102555153 (LOC102555153), ncRNA",".",".",".",".",".",".",".",".","pfam12786","GBV-C_env","GB virus C genotype envelope. This the envelope protein from the ssRNA GB virus genotype C.",".",".",".",".","."]
["ENSRNOG00000039048",46,3.819226384,27,1.736921831,2.198847591,1.13674761,0.00089699,0.000892676,"up","yes","Cd200r1","protein_coding","chr11:55887717-55921285:-","gi|13027398|ref|NP_076443.1|",1504,0,"cell surface glycoprotein CD200 receptor 1 precursor [Rattus norvegicus]","gi|672071194|ref|XM_008768743.1|",1760,0,"PREDICTED: Rattus norvegicus CD200 receptor 1 (Cd200r1), transcript variant X1, mRNA","Q9ES58",583,0,"Cell surface glycoprotein CD200 receptor 1",".",".",".",".","pfam08205","C2-set_2","CD80-like C2-set immunoglobulin domain. These domains belong to the immunoglobulin superfamily.","GO:0032715|negative regulation of interleukin-6 production;GO:0034113|heterotypic cell-cell adhesion;GO:0150077|regulation of neuroinflammatory response;GO:0150079|negative regulation of neuroinflammatory response;GO:1901215|negative regulation of neuron death;GO:1905522|negative regulation of macrophage migration;GO:2000405|negative regulation of T cell migration;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0043235|receptor complex;","GO:0038023|signaling receptor activity;GO:0086080|protein binding involved in heterotypic cell-cell adhesion;","K21668","CD200R; cell surface glycoprotein CD200 receptor"]
["ENSRNOG00000005404",39,3.23803976,21,1.350939202,2.396880449,1.261157952,0.000899551,0.000894807,"up","yes","Rasgrp1","protein_coding","chr3:104170013-104230056:-","gi|3237381|gb|AAC40137.1|",3661,0,"ras guanyl releasing protein [Rattus norvegicus]","gi|31377529|ref|NM_019211.2|",3118,0,"Rattus norvegicus RAS guanyl releasing protein 1 (Rasgrp1), mRNA","Q9R1K8",1414,0,"RAS guanyl-releasing protein 1",".",".",".",".","pfam00617","RasGEF","RasGEF domain. Guanine nucleotide exchange factor for Ras-like small GTPases.","GO:0001934|positive regulation of protein phosphorylation;GO:0002437|inflammatory response to antigenic stimulus;GO:0007264|small GTPase mediated signal transduction;GO:0014066|regulation of phosphatidylinositol 3-kinase signaling;GO:0030101|natural killer cell activation;GO:0030154|cell differentiation;GO:0032252|secretory granule localization;GO:0032725|positive regulation of granulocyte macrophage colony-stimulating factor production;GO:0032729|positive regulation of interferon-gamma production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032816|positive regulation of natural killer cell activation;GO:0032825|positive regulation of natural killer cell differentiation;GO:0033089|positive regulation of T cell differentiation in thymus;GO:0042098|T cell proliferation;GO:0042100|B cell proliferation;GO:0042110|T cell activation;GO:0042113|B cell activation;GO:0043303|mast cell degranulation;GO:0043406|positive regulation of MAP kinase activity;GO:0043547|positive regulation of GTPase activity;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;GO:0046330|positive regulation of JNK cascade;GO:0046579|positive regulation of Ras protein signal transduction;GO:0047496|vesicle transport along microtubule;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0090630|activation of GTPase activity;","GO:0000139|Golgi membrane;GO:0005789|endoplasmic reticulum membrane;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0005509|calcium ion binding;GO:0008270|zinc ion binding;GO:0019992|diacylglycerol binding;GO:0031210|phosphatidylcholine binding;GO:0042802|identical protein binding;","K04350","RASGRP1; RAS guanyl-releasing protein 1"]
["ENSRNOG00000057769",47,3.902253045,28,1.801252269,2.166411175,1.115307086,0.00094693,0.000939015,"up","yes","Oas1h","protein_coding","chr12:35683699-35693366:-","gi|57222310|ref|NP_001009491.1|",1932,0,"2 ' -5 ' oligoadenylate synthetase 1H [Rattus norvegicus]","gi|57222309|ref|NM_001009491.1|",1701,0,"Rattus norvegicus 2 ' -5 ' oligoadenylate synthetase 1H (Oas1h), mRNA","Q924S2",455,{"v":7e-155,"d":"7.00E-155"},"Inactive 2'-5' oligoadenylate synthetase 1C",".",".",".",".","pfam10421","OAS1_C","2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus. This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between 320 and 344 at the extreme C-terminal end. Oligoadenylate synthetases are antiviral enzymes that counteract vial attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesize 2'.5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication. This domain is often associated with NTP_transf_2 pfam01909.","GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0051607|defense response to virus;GO:0060700|regulation of ribonuclease activity;","GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0016020|membrane;","GO:0001730|2'-5'-oligoadenylate synthetase activity;GO:0003725|double-stranded RNA binding;",".","."]
["ENSRNOG00000017273",34,2.822906458,17,1.093617449,2.581255868,1.368073156,0.000962923,9.53691E-4,"up","yes","RGD1563917","protein_coding","chr9:86383201-86405361:-","gi|31324957|gb|AAH52931.1|",716,{"v":6e-89,"d":"6.00E-89"},"A630001G21Rik protein [Mus musculus]","gi|672024234|ref|XR_349184.2|",1153,0,"PREDICTED: Rattus norvegicus similar to Nuclear autoantigen Sp-100 (Speckled 100 kDa) (RGD1563917), misc_RNA","Q9H930",114,{"v":6e-26,"d":"6.00E-26"},"Nuclear body protein SP140-like protein",".",".",".",".","pfam03172","Sp100","Sp100 domain. The function of this domain is unknown. It is about 105 amino acid residues in length and is predicted to be predominantly alpha helical. This domain is usually found at the amino terminus of protein that contain a SAND domain pfam01342.","GO:0006357|regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;",".","."]
["ENSRNOG00000020478",40,3.321066421,22,1.41526964,2.346596244,1.230569632,0.000972467,0.000962399,"up","yes","Camk4","protein_coding","chr18:24585269-24802487:+","gi|564392948|ref|XP_006254585.1|",2113,0,"PREDICTED: calcium/calmodulin-dependent protein kinase type IV isoform X1 [Rattus norvegicus]","gi|203264|gb|M63334.1|RATCAMGRD",2193,0,"R.norvegicus calmodulin-dependent protein kinase(CaM kinase-GR) mRNA, complete cds","P13234",790,0,"Calcium/calmodulin-dependent protein kinase type IV",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0002250|adaptive immune response;GO:0006468|protein phosphorylation;GO:0006913|nucleocytoplasmic transport;GO:0006954|inflammatory response;GO:0007165|signal transduction;GO:0007270|neuron-neuron synaptic transmission;GO:0007616|long-term memory;GO:0018105|peptidyl-serine phosphorylation;GO:0035556|intracellular signal transduction;GO:0043011|myeloid dendritic cell differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0046777|protein autophosphorylation;GO:0046827|positive regulation of protein export from nucleus;GO:0099527|postsynapse to nucleus signaling pathway;","GO:0001650|fibrillar center;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0098794|postsynapse;GO:0098978|glutamatergic synapse;GO:0098982|GABA-ergic synapse;","GO:0004683|calmodulin-dependent protein kinase activity;GO:0005516|calmodulin binding;GO:0005524|ATP binding;GO:0009931|calcium-dependent protein serine/threonine kinase activity;","K05869","CAMK4; calcium/calmodulin-dependent protein kinase IV [EC:2.7.11.17]"]
["ENSRNOG00000058434",40,3.321066421,22,1.41526964,2.346596244,1.230569632,0.000972467,0.000962399,"up","yes","Cfap99","protein_coding","chr14:76410555-76468125:-","gi|672028054|ref|XP_008764562.1|",3190,0,"PREDICTED: cilia and flagella associated protein 99 isoform X1 [Rattus norvegicus]","gi|672028053|ref|XM_008766340.1|",2725,0,"PREDICTED: Rattus norvegicus similar to CG14998-PC, isoform C (RGD1564567), transcript variant X1, mRNA","D6REC4",441,{"v":3e-142,"d":"3.00E-142"},"Cilia- and flagella-associated protein 99",".",".",".",".","pfam13868","Trichoplein","tumor suppressor, Mitostatin. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs).",".",".",".","K25608","CFAP99; cilia- and flagella-associated protein 99"]
["ENSRNOG00000065113",40,3.321066421,22,1.41526964,2.346596244,1.230569632,0.000972467,0.000962399,"up","yes","ENSRNOG00000065113","lncRNA","chr19:10075536-10077345:-",".",".",".",".","gi|672084143|ref|XR_361613.2|",552,0,"PREDICTED: Rattus norvegicus G protein-coupled receptor 114 (Gpr114), transcript variant X13, misc_RNA",".",".",".",".",".",".",".",".","pfam12698","ABC2_membrane_3","ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family pfam01061.",".",".",".",".","."]
["ENSRNOG00000001608",48,3.985279705,29,1.865582707,2.136211753,1.095054662,0.00099588,0.000984198,"up","yes","Nxpe3","protein_coding","chr11:44727069-44777694:+","gi|157821953|ref|NP_001102905.1|",2883,0,"NXPE family member 3 [Rattus norvegicus]","gi|157821952|ref|NM_001109435.1|",3137,0,"Rattus norvegicus neurexophilin and PC-esterase domain family, member 3 (Nxpe3), mRNA","Q5RCA5",1005,0,"NXPE family member 3",".",".",".",".","pfam06312","Neurexophilin","Neurexophilin. This family consists of mammalian neurexophilin proteins. Mammalian brains contain four different neurexophilin proteins. Neurexophilins form a family of related glycoproteins that are proteolytically processed after synthesis and bind to alpha-neurexins. The structure and characteristics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins.",".",".",".",".","."]
["ENSRNOG00000027997",22,1.826586532,8,0.514643505,3.549226818,1.827504775,0.001053857,0.001036528,"up","yes","ENSRNOG00000027997","protein_coding","chr11:41968796-41972351:+","gi|293352141|ref|XP_001057542.2|",909,{"v":1e-122,"d":"1.00E-122"},"PREDICTED: ferritin, heavy subunit [Rattus norvegicus]","gi|672025956|ref|XM_003752507.3|",575,0,"PREDICTED: Rattus norvegicus similar to CG4349-PA (LOC680520), mRNA",".",".",".",".",".",".",".",".","pfam00210","Ferritin","Ferritin-like domain. This family contains ferritins and other ferritin-like proteins such as members of the DPS family and bacterioferritins.","GO:0006826|iron ion transport;GO:0006880|intracellular sequestering of iron ion;","GO:0005737|cytoplasm;","GO:0008198|ferrous iron binding;GO:0008199|ferric iron binding;",".","."]
["ENSRNOG00000068243",35,2.905933118,18,1.157947887,2.509554316,1.327431172,1.064862E-3,0.001046226,"up","yes","Cdk5r1","protein_coding","chr10:65483941-65488456:+","gi|6753384|ref|NP_034001.1|",1404,{"v":2e-178,"d":"2.00E-178"},"cyclin-dependent kinase 5 activator 1 [Mus musculus]","gi|30722338|emb|AL591146.21|",2602,0,"Mouse DNA sequence from clone RP23-252E4 on chromosome 11, complete sequence","P61810",545,{"v":6e-180,"d":"6.00E-180"},"Cyclin-dependent kinase 5 activator 1",".",".",".",".","pfam03261","CDK5_activator","Cyclin-dependent kinase 5 activator protein.",".",".",".",".","."]
["ENSRNOG00000068691",19,1.57750655,6,0.385982629,4.086988458,2.031038169,0.00109076,0.001070191,"up","yes","ENSRNOG00000068691","protein_coding","chr10:107141088-107153722:+","gi|672025601|ref|XP_008773896.1|",2861,0,"PREDICTED: zinc finger protein 431-like [Rattus norvegicus]","gi|672025600|ref|XM_008775674.1|",2068,0,"PREDICTED: Rattus norvegicus zinc finger protein 431-like (LOC103695201), mRNA","E9QAG8",659,0,"Zinc finger protein 431",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000069349",19,1.57750655,6,0.385982629,4.086988458,2.031038169,0.00109076,0.001070191,"up","yes","ENSRNOG00000069349","lncRNA","chr3:157193604-157198233:+",".",".",".",".","gi|672017758|ref|XR_600482.1|",495,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102554533 (LOC102554533), ncRNA",".",".",".",".",".",".",".",".","pfam04148","Erv26","Transmembrane adaptor Erv26. Erv26 is an integral membrane protein that is packed into COPII vesicles and cycles between the ER and Golgi compartments. It directs pro-alkaline phosphatase into endoplasmic reticulum-derived COPII transport vesicles.",".",".",".",".","."]
["ENSRNOG00000004281",42,3.487119742,24,1.543930516,2.258598884,1.175428078,0.001116584,0.001093514,"up","yes","Cobl","protein_coding","chr14:86828139-87060800:-","gi|672076787|ref|XP_008768533.1|",6146,0,"PREDICTED: protein cordon-bleu isoform X4 [Rattus norvegicus]","gi|672076786|ref|XM_008770311.1|",3155,0,"PREDICTED: Rattus norvegicus cordon-bleu WH2 repeat protein (Cobl), transcript variant X4, mRNA","Q5NBX1",2063,0,"Protein cordon-bleu",".",".",".",".","pfam09469","Cobl","Cordon-bleu ubiquitin-like domain. The Cordon-bleu protein domain is highly conserved among vertebrates. The sequence contains three repeated lysine, arginine, and proline-rich regions, the KKRAP motif. The exact function of the protein is unknown but it is thought to be involved in mid-brain neural tube closure. It is expressed specifically in the node. This domain has a ubiquitin-like fold.","GO:0000578|embryonic axis specification;GO:0001757|somite specification;GO:0001843|neural tube closure;GO:0001889|liver development;GO:0030036|actin cytoskeleton organization;GO:0030041|actin filament polymerization;GO:0030903|notochord development;GO:0033504|floor plate development;GO:0048565|digestive tract development;GO:0048669|collateral sprouting in absence of injury;GO:0051639|actin filament network formation;GO:1900006|positive regulation of dendrite development;GO:1900029|positive regulation of ruffle assembly;","GO:0001726|ruffle;GO:0005829|cytosol;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0005938|cell cortex;GO:0016020|membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0043025|neuronal cell body;GO:0044294|dendritic growth cone;GO:0044295|axonal growth cone;GO:0048471|perinuclear region of cytoplasm;GO:1990357|terminal web;","GO:0003785|actin monomer binding;GO:0005515|protein binding;","K18623","COBL; protein cordon-bleu"]
["ENSRNOG00000047363",42,3.487119742,24,1.543930516,2.258598884,1.175428078,0.001116584,0.001093514,"up","yes","Kcnk13","protein_coding","chr6:119242188-119345240:+","gi|564356934|ref|XP_006240509.1|",2078,0,"PREDICTED: potassium channel subfamily K member 13 isoform X1 [Rattus norvegicus]","gi|672056773|ref|XM_006240447.2|",2032,0,"PREDICTED: Rattus norvegicus potassium channel, subfamily K, member 13 (Kcnk13), transcript variant X2, mRNA","Q9ERS0",799,0,"Potassium channel subfamily K member 13",".",".",".",".","pfam07885","Ion_trans_2","Ion channel. This family includes the two membrane helix type ion channels found in bacteria.","GO:0030322|stabilization of membrane potential;GO:0034765|regulation of ion transmembrane transport;GO:0071805|potassium ion transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;","GO:0005244|voltage-gated ion channel activity;GO:0005267|potassium channel activity;GO:0022841|potassium ion leak channel activity;","K04922","KCNK13, K2P13.1; potassium channel subfamily K member 13"]
["ENSRNOG00000019661",26,2.158693174,11,0.70763482,3.050575117,1.609081256,0.001128213,0.00110372,"up","yes","Gdf15","protein_coding","chr16:18805239-18808055:+","gi|149036052|gb|EDL90718.1|",1249,{"v":5e-169,"d":"5.00E-169"},"growth differentiation factor 15 [Rattus norvegicus]","gi|257153310|ref|NM_019216.2|",906,0,"Rattus norvegicus growth differentiation factor 15 (Gdf15), mRNA","Q9Z0J6",481,{"v":1E-168,"d":"1.00E-168"},"Growth/differentiation factor 15",".",".",".",".","pfam00019","TGF_beta","Transforming growth factor beta like domain.","GO:0002023|reduction of food intake in response to dietary excess;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0030509|BMP signaling pathway;GO:0035860|glial cell-derived neurotrophic factor receptor signaling pathway;GO:0040015|negative regulation of multicellular organism growth;GO:0043410|positive regulation of MAPK cascade;GO:0051897|positive regulation of protein kinase B signaling;GO:0060395|SMAD protein signal transduction;GO:0060400|negative regulation of growth hormone receptor signaling pathway;GO:1901741|positive regulation of myoblast fusion;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;","GO:0005125|cytokine activity;GO:0008083|growth factor activity;GO:0042803|protein homodimerization activity;GO:0070700|BMP receptor binding;","K05504","GDF15; growth differentiation factor 15"]
["ENSRNOG00000067556",26,2.158693174,11,0.70763482,3.050575117,1.609081256,0.001128213,0.00110372,"up","yes","ENSRNOG00000067556","lncRNA","chr1:243438450-243442581:+","gi|696994985|ref|XP_009564302.1|",141,{"v":3E-11,"d":"3.00E-11"},"PREDICTED: LOW QUALITY PROTEIN: RNA-directed DNA polymerase from mobile element jockey-like, partial [Cuculus canorus]","gi|30270591|gb|AC103018.7|",554,0,"Rattus norvegicus 1 CH230-196F22 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam09492","Pec_lyase","Pectic acid lyase. Members of this family are isozymes of pectate lyase (EC:4.2.2.2), also called polygalacturonic transeliminase and alpha-1,4-D-endopolygalacturonic acid lyase.",".",".",".",".","."]
["ENSRNOG00000004158",51,4.234359687,32,2.058574022,2.05693827,1.040498498,1.135612E-3,0.001110278,"up","yes","Hdac9","protein_coding","chr6:50763590-51625333:-","gi|672055858|ref|XP_008762835.1|",2136,0,"PREDICTED: histone deacetylase 9 isoform X4 [Rattus norvegicus]","gi|672055857|ref|XM_008764613.1|",3831,0,"PREDICTED: Rattus norvegicus histone deacetylase 9 (Hdac9), transcript variant X4, mRNA","Q99N13",504,{"v":2e-158,"d":"2.00E-158"},"Histone deacetylase 9",".",".",".",".","pfam12203","HDAC4_Gln","Glutamine rich N terminal domain of histone deacetylase 4. This domain is found in eukaryotes, and is approximately 90 amino acids in length. The family is found in association with pfam00850. The domain forms an alpha helix which complexes to form a tetramer. The glutamine rich domains have many intra- and inter-helical interactions which are thought to be involved in reversible assembly and disassembly of proteins. The domain is part of histone deacetylase 4 (HDAC4) which removes acetyl groups from histones. This restores their positive charge to allow stronger DNA binding thus restricting transcriptional activity.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001818|negative regulation of cytokine production;GO:0001975|response to amphetamine;GO:0006281|DNA repair;GO:0007507|heart development;GO:0008340|determination of adult lifespan;GO:0016575|histone deacetylation;GO:0030182|neuron differentiation;GO:0032869|cellular response to insulin stimulus;GO:0034983|peptidyl-lysine deacetylation;GO:0042632|cholesterol homeostasis;GO:0045892|negative regulation of transcription, DNA-templated;GO:0048742|regulation of skeletal muscle fiber development;GO:0051005|negative regulation of lipoprotein lipase activity;GO:0051153|regulation of striated muscle cell differentiation;GO:0070932|histone H3 deacetylation;GO:0070933|histone H4 deacetylation;GO:0090050|positive regulation of cell migration involved in sprouting angiogenesis;GO:1990678|histone H4-K16 deacetylation;","GO:0000118|histone deacetylase complex;GO:0005634|nucleus;GO:0005667|transcription factor complex;GO:0005737|cytoplasm;GO:0035097|histone methyltransferase complex;","GO:0003674|molecular_function;GO:0003714|transcription corepressor activity;GO:0004407|histone deacetylase activity;GO:0005080|protein kinase C binding;GO:0032041|NAD-dependent histone deacetylase activity (H3-K14 specific);GO:0033558|protein deacetylase activity;GO:0034739|histone deacetylase activity (H4-K16 specific);GO:0042826|histone deacetylase binding;GO:0046872|metal ion binding;","K11409","HDAC9; histone deacetylase 9 [EC:3.5.1.98]"]
["ENSRNOG00000026286",51,4.234359687,32,2.058574022,2.05693827,1.040498498,1.135612E-3,0.001110278,"up","yes","Nhlrc1","protein_coding","chr17:17674319-17677148:+","gi|40385887|ref|NP_954706.1|",1791,0,"E3 ubiquitin-protein ligase NHLRC1 [Rattus norvegicus]","gi|34849941|gb|AC133492.10|",2830,0,"Rattus norvegicus clone rp32-478o16, complete sequence","Q6IMG5",694,0,"E3 ubiquitin-protein ligase NHLRC1",".",".",".",".","pfam13920","zf-C3HC4_3","Zinc finger, C3HC4 type (RING finger).","GO:0000209|protein polyubiquitination;GO:0001932|regulation of protein phosphorylation;GO:0005977|glycogen metabolic process;GO:0005978|glycogen biosynthetic process;GO:0006914|autophagy;GO:0010468|regulation of gene expression;GO:0031396|regulation of protein ubiquitination;GO:0031398|positive regulation of protein ubiquitination;GO:0034976|response to endoplasmic reticulum stress;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0044260|cellular macromolecule metabolic process;GO:0045859|regulation of protein kinase activity;GO:1903076|regulation of protein localization to plasma membrane;","GO:0005634|nucleus;GO:0005783|endoplasmic reticulum;GO:0048471|perinuclear region of cytoplasm;","GO:0004842|ubiquitin-protein transferase activity;GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;","K10602","NHLRC1; E3 ubiquitin-protein ligase NHLRC1 [EC:2.3.2.27]"]
["ENSRNOG00000062478",51,4.234359687,32,2.058574022,2.05693827,1.040498498,1.135612E-3,0.001110278,"up","yes","ENSRNOG00000062478","protein_coding","chr6:89507438-89508765:-","gi|927175942|ref|XP_013834805.1|",193,{"v":3e-15,"d":"3.00E-15"},"PREDICTED: LOW QUALITY PROTEIN: endogenous retrovirus group 3 member 1 Env polyprotein-like [Sus scrofa]","gi|672020801|ref|XR_347306.2|",246,{"v":2e-124,"d":"2.00E-124"},"PREDICTED: Rattus norvegicus uncharacterized LOC102552179 (LOC102552179), transcript variant X3, ncRNA",".",".",".",".",".",".",".",".","pfam11101","DUF2884","Protein of unknown function (DUF2884). Some members in this bacterial family of proteins are annotated as YggN which currently has no known function.",".",".",".",".","."]
["ENSRNOG00000004452",9,0.747239945,0,0.032165219,23.23130281,4.537998158,1.143263E-3,0.001115882,"up","yes","Aqp12a","protein_coding","chr9:93554527-93560011:+","gi|157823855|ref|NP_001102479.1|",1346,0,"aquaporin-12 precursor [Rattus norvegicus]","gi|157823854|ref|NM_001109009.1|",1093,0,"Rattus norvegicus aquaporin 12A (Aqp12a), mRNA","Q8CHJ2",488,{"v":3e-172,"d":"3.00E-172"},"Aquaporin-12",".",".",".",".","pfam00230","MIP","Major intrinsic protein. MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.","GO:0055085|transmembrane transport;","GO:0005737|cytoplasm;GO:0016021|integral component of membrane;","GO:0015267|channel activity;","K09871","AQP12; aquaporin-12"]
["ENSRNOG00000008138",9,0.747239945,0,0.032165219,23.23130281,4.537998158,1.143263E-3,0.001115882,"up","yes","Jhy","protein_coding","chr8:41276491-41333514:-","gi|672061558|ref|XP_008764351.1|",3181,0,"PREDICTED: uncharacterized protein C11orf63 homolog isoform X2 [Rattus norvegicus]","gi|672061557|ref|XM_008766129.1|",2193,0,"PREDICTED: Rattus norvegicus similar to hypothetical protein FLJ23554 (RGD1309108), transcript variant X2, mRNA","E9Q793",1039,0,"Jhy protein",".",".",".",".","pfam15261","DUF4591","Domain of unknown function (DUF4591). This protein family is a domain of unknown function. It is found in eukaryotes, and is approximately 120 amino acids in length. In humans, the gene encoding this protein lies in the position chromosome 11 open reading frame 63.",".",".",".",".","."]
["ENSRNOG00000010685",9,0.747239945,0,0.032165219,23.23130281,4.537998158,1.143263E-3,0.001115882,"up","yes","Tbx18","protein_coding","chr8:88652054-88680058:-","gi|157823511|ref|NP_001101643.1|",2679,0,"T-box transcription factor TBX18 [Rattus norvegicus]","gi|157823510|ref|NM_001108173.1|",4611,0,"Rattus norvegicus T-box18 (Tbx18), mRNA","Q9EPZ6",993,0,"T-box transcription factor TBX18",".",".",".",".","pfam00907","T-box","T-box. The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001708|cell fate specification;GO:0001756|somitogenesis;GO:0002053|positive regulation of mesenchymal cell proliferation;GO:0003163|sinoatrial node development;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007605|sensory perception of sound;GO:0008150|biological_process;GO:0009948|anterior/posterior axis specification;GO:0016331|morphogenesis of embryonic epithelium;GO:0022409|positive regulation of cell-cell adhesion;GO:0030154|cell differentiation;GO:0048646|anatomical structure formation involved in morphogenesis;GO:0050679|positive regulation of epithelial cell proliferation;GO:0051145|smooth muscle cell differentiation;GO:0060829|negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation;GO:0060930|sinoatrial node cell fate commitment;GO:0060931|sinoatrial node cell development;GO:0072189|ureter development;GO:0090103|cochlea morphogenesis;GO:0098907|regulation of SA node cell action potential;GO:2000729|positive regulation of mesenchymal cell proliferation involved in ureter development;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0090571|RNA polymerase II transcription repressor complex;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0042803|protein homodimerization activity;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;GO:1990837|sequence-specific double-stranded DNA binding;","K10183","TBX18; T-box protein 18"]
["ENSRNOG00000021763",9,0.747239945,0,0.032165219,23.23130281,4.537998158,1.143263E-3,0.001115882,"up","yes","Ffar4","protein_coding","chr1:235873576-235891597:+","gi|114052953|ref|NP_001040553.1|",1673,0,"free fatty acid receptor 4 [Rattus norvegicus]","gi|114052952|ref|NM_001047088.1|",1379,0,"Rattus norvegicus free fatty acid receptor 4 (Ffar4), mRNA","Q2AC31",649,0,"Free fatty acid receptor 4",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001818|negative regulation of cytokine production;GO:0006954|inflammatory response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0010827|regulation of glucose transmembrane transport;GO:0032691|negative regulation of interleukin-1 beta production;GO:0036321|ghrelin secretion;GO:0043066|negative regulation of apoptotic process;GO:0043950|positive regulation of cAMP-mediated signaling;GO:0045444|fat cell differentiation;GO:0045669|positive regulation of osteoblast differentiation;GO:0046879|hormone secretion;GO:0050728|negative regulation of inflammatory response;GO:0050872|white fat cell differentiation;GO:0050873|brown fat cell differentiation;GO:0050912|detection of chemical stimulus involved in sensory perception of taste;GO:0070094|positive regulation of glucagon secretion;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0090275|negative regulation of somatostatin secretion;GO:0090336|positive regulation of brown fat cell differentiation;GO:0120162|positive regulation of cold-induced thermogenesis;","GO:0005765|lysosomal membrane;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005929|cilium;GO:0010008|endosome membrane;GO:0030139|endocytic vesicle;GO:0060170|ciliary membrane;","GO:0004930|G protein-coupled receptor activity;GO:0005504|fatty acid binding;GO:0008527|taste receptor activity;GO:1990763|arrestin family protein binding;","K08425","FFAR4, GPR120; free fatty acid receptor 4"]
["ENSRNOG00000051330",9,0.747239945,0,0.032165219,23.23130281,4.537998158,1.143263E-3,0.001115882,"up","yes","AABR07006538.1","protein_coding","chr1:219079683-219084806:+","gi|672014897|ref|XP_008773047.1|",693,{"v":7e-90,"d":"7.00E-90"},"PREDICTED: uncharacterized protein C9orf57 homolog, partial [Rattus norvegicus]","gi|672014896|ref|XM_008774825.1|",596,0,"PREDICTED: Rattus norvegicus uncharacterized LOC100911842 (LOC100911842), partial mRNA","Q5W0N0",117,{"v":7e-31,"d":"7.00E-31"},"Uncharacterized protein C9orf57",".",".",".",".","pfam05014","Nuc_deoxyrib_tr","Nucleoside 2-deoxyribosyltransferase. Nucleoside 2-deoxyribosyltransferase EC:2.4.2.6 catalyses the cleavage of the glycosidic bonds of 2`-deoxyribonucleosides.",".",".",".",".","."]
["ENSRNOG00000060278",9,0.747239945,0,0.032165219,23.23130281,4.537998158,1.143263E-3,0.001115882,"up","yes","Cpg1","protein_coding","chr6:118312220-118324213:+","gi|30017435|ref|NP_835205.1|",353,{"v":3e-35,"d":"3.00E-35"},"candidate plasticity gene 1 [Rattus norvegicus]","gi|31342496|ref|NM_178104.2|",4122,0,"Rattus norvegicus candidate plasticity gene 1 (Cpg1), mRNA",".",".",".",".",".",".",".",".",".",".",".","GO:0048168|regulation of neuronal synaptic plasticity;",".",".",".","."]
["ENSRNOG00000054603",14,1.162373247,3,0.192991315,6.022930358,2.590465578,0.001173027,0.001142317,"up","yes","Pacsin1","protein_coding","chr20:5719857-5765313:+","gi|8393896|ref|NP_058990.1|",1750,0,"protein kinase C and casein kinase substrate in neurons protein 1 [Rattus norvegicus]","gi|8393895|ref|NM_017294.1|",1231,0,"Rattus norvegicus protein kinase C and casein kinase substrate in neurons 1 (Pacsin1), mRNA","Q9Z0W5",678,0,"Protein kinase C and casein kinase substrate in neurons protein 1",".",".",".",".","pfam14604","SH3_9","Variant SH3 domain.","GO:0007010|cytoskeleton organization;GO:0007015|actin filament organization;GO:0030100|regulation of endocytosis;GO:0045806|negative regulation of endocytosis;GO:0048488|synaptic vesicle endocytosis;GO:0048666|neuron development;GO:0048812|neuron projection morphogenesis;GO:0072657|protein localization to membrane;GO:0072659|protein localization to plasma membrane;GO:0097320|plasma membrane tubulation;GO:0099149|regulation of postsynaptic neurotransmitter receptor internalization;GO:1900006|positive regulation of dendrite development;","GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0030137|COPI-coated vesicle;GO:0030659|cytoplasmic vesicle membrane;GO:0032587|ruffle membrane;GO:0043005|neuron projection;GO:0043195|terminal bouton;GO:0043679|axon terminus;GO:0045202|synapse;GO:0048471|perinuclear region of cytoplasm;GO:0098684|photoreceptor ribbon synapse;GO:0098833|presynaptic endocytic zone;GO:0098839|postsynaptic density membrane;GO:0098978|glutamatergic synapse;","GO:0005515|protein binding;GO:0005543|phospholipid binding;GO:0008092|cytoskeletal protein binding;GO:0042802|identical protein binding;","K20123","PACSIN; protein kinase C and casein kinase substrate in neurons protein"]
["ENSRNOG00000059793",31,2.573826476,15,0.964956573,2.66729773,1.415378871,0.001218508,1.182645E-3,"up","yes","Rab37","protein_coding","chr10:100334216-100401474:+","gi|568975071|ref|XP_006533919.1|",1339,{"v":5e-178,"d":"5.00E-178"},"PREDICTED: ras-related protein Rab-37 isoform X1 [Mus musculus]","gi|672025436|ref|XM_002724576.4|",1579,0,"PREDICTED: Rattus norvegicus rCG35079-like (LOC100364984), transcript variant X1, mRNA","Q9JKM7",393,{"v":2e-130,"d":"2.00E-130"},"Ras-related protein Rab-37",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.",".","GO:0005768|endosome;GO:0005793|endoplasmic reticulum-Golgi intermediate compartment;GO:0005794|Golgi apparatus;GO:0030141|secretory granule;","GO:0003924|GTPase activity;GO:0005525|GTP binding;","K07914","RAB37; Ras-related protein Rab-37"]
["ENSRNOG00000007468",10,0.830266605,1,0.064330438,12.90627934,3.690001251,1.241238E-3,1.202152E-3,"up","yes","Ifng","protein_coding","chr7:53903337-53907375:+","gi|20302055|ref|NP_620235.1|",740,{"v":1E-97,"d":"1.00E-97"},"interferon gamma precursor [Rattus norvegicus]","gi|24475821|ref|NM_138880.2|",508,0,"Rattus norvegicus interferon gamma (Ifng), mRNA","P01581",289,{"v":5e-99,"d":"5.00E-99"},"Interferon gamma",".",".",".",".","pfam00714","IFN-gamma","Interferon gamma.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001774|microglial cell activation;GO:0001781|neutrophil apoptotic process;GO:0001819|positive regulation of cytokine production;GO:0001934|positive regulation of protein phosphorylation;GO:0002026|regulation of the force of heart contraction;GO:0002250|adaptive immune response;GO:0002281|macrophage activation involved in immune response;GO:0002302|CD8-positive, alpha-beta T cell differentiation involved in immune response;GO:0006355|regulation of transcription, DNA-templated;GO:0006915|apoptotic process;GO:0006925|inflammatory cell apoptotic process;GO:0006959|humoral immune response;GO:0007259|JAK-STAT cascade;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0009410|response to xenobiotic stimulus;GO:0009615|response to virus;GO:0010508|positive regulation of autophagy;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010634|positive regulation of epithelial cell migration;GO:0010835|regulation of protein ADP-ribosylation;GO:0019882|antigen processing and presentation;GO:0030225|macrophage differentiation;GO:0030593|neutrophil chemotaxis;GO:0030857|negative regulation of epithelial cell differentiation;GO:0030968|endoplasmic reticulum unfolded protein response;GO:0031334|positive regulation of protein complex assembly;GO:0031642|negative regulation of myelination;GO:0032224|positive regulation of synaptic transmission, cholinergic;GO:0032700|negative regulation of interleukin-17 production;GO:0032722|positive regulation of chemokine production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032735|positive regulation of interleukin-12 production;GO:0032747|positive regulation of interleukin-23 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032834|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response;GO:0033141|positive regulation of peptidyl-serine phosphorylation of STAT protein;GO:0034393|positive regulation of smooth muscle cell apoptotic process;GO:0040008|regulation of growth;GO:0042102|positive regulation of T cell proliferation;GO:0042307|positive regulation of protein import into nucleus;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0042742|defense response to bacterium;GO:0042832|defense response to protozoan;GO:0043065|positive regulation of apoptotic process;GO:0044794|positive regulation by host of viral process;GO:0045348|positive regulation of MHC class II biosynthetic process;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0045666|positive regulation of neuron differentiation;GO:0045671|negative regulation of osteoclast differentiation;GO:0045672|positive regulation of osteoclast differentiation;GO:0045785|positive regulation of cell adhesion;GO:0045821|positive regulation of glycolytic process;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048143|astrocyte activation;GO:0048147|negative regulation of fibroblast proliferation;GO:0048304|positive regulation of isotype switching to IgG isotypes;GO:0048662|negative regulation of smooth muscle cell proliferation;GO:0050691|regulation of defense response to virus by host;GO:0050729|positive regulation of inflammatory response;GO:0050766|positive regulation of phagocytosis;GO:0050769|positive regulation of neurogenesis;GO:0050776|regulation of immune response;GO:0050796|regulation of insulin secretion;GO:0050830|defense response to Gram-positive bacterium;GO:0050852|T cell receptor signaling pathway;GO:0050954|sensory perception of mechanical stimulus;GO:0051044|positive regulation of membrane protein ectodomain proteolysis;GO:0051173|positive regulation of nitrogen compound metabolic process;GO:0051607|defense response to virus;GO:0051712|positive regulation of killing of cells of other organism;GO:0051726|regulation of cell cycle;GO:0051770|positive regulation of nitric-oxide synthase biosynthetic process;GO:0060251|regulation of glial cell proliferation;GO:0060333|interferon-gamma-mediated signaling pathway;GO:0060550|positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity;GO:0060552|positive regulation of fructose 1,6-bisphosphate metabolic process;GO:0060557|positive regulation of vitamin D biosynthetic process;GO:0060559|positive regulation of calcidiol 1-monooxygenase activity;GO:0071222|cellular response to lipopolysaccharide;GO:0071351|cellular response to interleukin-18;GO:0071902|positive regulation of protein serine/threonine kinase activity;GO:0072125|negative regulation of glomerular mesangial cell proliferation;GO:0090312|positive regulation of protein deacetylation;GO:0097191|extrinsic apoptotic signaling pathway;GO:0098908|regulation of neuronal action potential;GO:0150076|neuroinflammatory response;GO:1900222|negative regulation of amyloid-beta clearance;GO:1901216|positive regulation of neuron death;GO:1901857|positive regulation of cellular respiration;GO:1902004|positive regulation of amyloid-beta formation;GO:1902948|negative regulation of tau-protein kinase activity;GO:1904440|positive regulation of ferrous iron import across plasma membrane;GO:1904783|positive regulation of NMDA glutamate receptor activity;GO:1904798|positive regulation of core promoter binding;GO:2000273|positive regulation of signaling receptor activity;GO:2000309|positive regulation of tumor necrosis factor (ligand) superfamily member 11 production;GO:2000345|regulation of hepatocyte proliferation;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0009897|external side of plasma membrane;GO:0043005|neuron projection;GO:0043204|perikaryon;","GO:0005125|cytokine activity;GO:0005133|interferon-gamma receptor binding;","K04687","IFNG; interferon gamma"]
["ENSRNOG00000028721",10,0.830266605,1,0.064330438,12.90627934,3.690001251,1.241238E-3,1.202152E-3,"up","yes","Otor","protein_coding","chr3:130415339-130418601:+","gi|157822605|ref|NP_001102430.1|",619,{"v":2e-77,"d":"2.00E-77"},"otoraplin precursor [Rattus norvegicus]","gi|157822604|ref|NM_001108960.1|",906,0,"Rattus norvegicus otoraplin (Otor), mRNA","Q9JIE3",229,{"v":1E-73,"d":"1.00E-73"},"Otoraplin",".",".",".",".","pfam07653","SH3_2","Variant SH3 domain. SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta barrel.","GO:0001502|cartilage condensation;",".",".","K25714","OTOR; otoraplin"]
["ENSRNOG00000042030",10,0.830266605,1,0.064330438,12.90627934,3.690001251,1.241238E-3,1.202152E-3,"up","yes","Nlrp4a","protein_coding","chr1:66170592-66245316:-","gi|157819251|ref|NP_001099690.1|",4942,0,"NACHT, LRR and PYD domains-containing protein 4A [Rattus norvegicus]","gi|672034949|ref|XM_008758899.1|",3930,0,"PREDICTED: Rattus norvegicus NLR family, pyrin domain containing 4A (Nlrp4a), transcript variant X1, mRNA","Q8BU40",1580,0,"NACHT, LRR and PYD domains-containing protein 4A",".",".",".",".","pfam05729","NACHT","NACHT domain. This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.",".",".",".","K22265","NLRP4; NACHT, LRR and PYD domains-containing protein 4"]
["ENSRNOG00000064361",10,0.830266605,1,0.064330438,12.90627934,3.690001251,1.241238E-3,1.202152E-3,"up","yes","ENSRNOG00000064361","lncRNA","chr14:13395290-13411107:-","gi|149041561|gb|EDL95402.1|",180,{"v":2e-13,"d":"2.00E-13"},"rCG57925 [Rattus norvegicus]","gi|47077929|gb|AC110133.5|",542,0,"Rattus norvegicus 3 BAC CH230-40N24 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam15268","Dapper","Dapper. This is a family of signalling proteins. They act in a diverse range of signaling pathways and have a range of binding partners. They act as homo- and heterodimers.",".",".",".",".","."]
["ENSRNOG00000069321",44,3.653173063,26,1.672591393,2.184139581,1.127065057,0.001256502,1.215278E-3,"up","yes","Ttc30a","protein_coding","chr3:60901896-60905350:-","gi|407339769|ref|NP_001258423.1|",3473,0,"tetratricopeptide repeat domain 30B [Rattus norvegicus]","gi|407339768|ref|NM_001271494.1|",3455,0,"Rattus norvegicus tetratricopeptide repeat domain 30A (Ttc30a), mRNA","Q99J38",1313,0,"Tetratricopeptide repeat protein 30A1",".",".",".",".","pfam13414","TPR_11","TPR repeat.",".",".",".",".","."]
["ENSRNOG00000003601",12,0.996319926,2,0.128660876,7.743767604,2.953035657,0.001297294,0.00125057,"up","yes","RGD1564463","protein_coding","chr13:92831537-92839246:+","gi|34881169|ref|XP_223005.2|",1730,0,"PREDICTED: sphingolipid delta(4)-desaturase DES1 [Rattus norvegicus]","gi|672027459|ref|XM_001062653.3|",1512,0,"PREDICTED: Rattus norvegicus similar to Mdes protein (RGD1564463), mRNA","O09005",527,0,"Sphingolipid delta(4)-desaturase DES1",".",".",".",".","pfam00487","FA_desaturase","Fatty acid desaturase.","GO:0046513|ceramide biosynthetic process;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0031966|mitochondrial membrane;","GO:0042284|sphingolipid delta-4 desaturase activity;GO:0050251|retinol isomerase activity;","K04712","DEGS; sphingolipid 4-desaturase/C4-monooxygenase [EC:1.14.19.17 1.14.18.5]"]
["ENSRNOG00000036700",12,0.996319926,2,0.128660876,7.743767604,2.953035657,0.001297294,0.00125057,"up","yes","Fscn2","protein_coding","chr10:105634783-105641322:+","gi|157818957|ref|NP_001100542.1|",2637,0,"fascin-2 [Rattus norvegicus]","gi|157818956|ref|NM_001107072.1|",1710,0,"Rattus norvegicus fascin actin-bundling protein 2, retinal (Fscn2), mRNA","Q32M02",1001,0,"Fascin-2",".",".",".",".","pfam06268","Fascin","Fascin domain. This family consists of several eukaryotic fascin or singed proteins. The fascins are a structurally unique and evolutionarily conserved group of actin cross-linking proteins. Fascins function in the organisation of two major forms of actin-based structures: dynamic, cortical cell protrusions and cytoplasmic microfilament bundles. The cortical structures, which include filopodia, spikes, lamellipodial ribs, oocyte microvilli and the dendrites of dendritic cells, have roles in cell-matrix adhesion, cell interactions and cell migration, whereas the cytoplasmic actin bundles appear to participate in cell architecture.  Dictyostelium hisactophilin, another actin-binding protein, is a submembranous pH sensor that signals slight changes of the H+ concentration to actin by inducing actin polymerization and binding to microfilaments only at pH values below seven. Members of this family are histidine rich, typically contain the repeated motif of HHXH.","GO:0007163|establishment or maintenance of cell polarity;GO:0008150|biological_process;GO:0016477|cell migration;GO:0042462|eye photoreceptor cell development;GO:0051017|actin filament bundle assembly;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0015629|actin cytoskeleton;GO:0032420|stereocilium;","GO:0005515|protein binding;GO:0030674|protein binding, bridging;GO:0051015|actin filament binding;","K17455","FSCN2; fascin2"]
["ENSRNOG00000068642",12,0.996319926,2,0.128660876,7.743767604,2.953035657,0.001297294,0.00125057,"up","yes","Slc6a20","protein_coding","chr8:123281472-123322573:-","gi|149018114|gb|EDL76755.1|",3050,0,"rCG25839 [Rattus norvegicus]","gi|298892765|emb|FQ211786.1|",2899,0,"Rattus norvegicus TL0AAA80YC01 mRNA sequence","Q64093",1173,0,"Sodium- and chloride-dependent transporter XTRP3","AF1995",147,{"v":3e-36,"d":"3.00E-36"},"COG0733","pfam00209","SNF","Sodium:neurotransmitter symporter family.",".",".",".",".","."]
["ENSRNOG00000027739",45,3.736199724,27,1.736921831,2.151046557,1.10503875,0.001324295,0.001274869,"up","yes","Cndp1","protein_coding","chr18:77984907-78007765:-","gi|56090459|ref|NP_001007688.1|",2639,0,"beta-Ala-His dipeptidase [Rattus norvegicus]","gi|672083414|ref|XM_008772135.1|",2620,0,"PREDICTED: Rattus norvegicus carnosine dipeptidase 1 (metallopeptidase M20 family) (Cndp1), transcript variant X2, mRNA","Q66HG3",1021,0,"Beta-Ala-His dipeptidase","SPBC1198.08",429,{"v":7e-140,"d":"7.00E-140"},"COG0624","pfam01546","Peptidase_M20","Peptidase family M20/M25/M40. This family includes a range of zinc metallopeptidases belonging to several families in the peptidase classification. Family M20 are Glutamate carboxypeptidases. Peptidase family M25 contains X-His dipeptidases.","GO:0006508|proteolysis;GO:0032268|regulation of cellular protein metabolic process;","GO:0005829|cytosol;","GO:0004180|carboxypeptidase activity;GO:0008233|peptidase activity;GO:0016805|dipeptidase activity;GO:0046872|metal ion binding;GO:0070573|metallodipeptidase activity;","K05604","CNDP1; beta-Ala-His dipeptidase [EC:3.4.13.20]"]
["ENSRNOG00000065061",17,1.411453229,5,0.321652191,4.388134975,2.133607903,0.001431745,0.001368624,"up","yes","ENSRNOG00000065061","lncRNA","chr10:53663938-53666998:-","gi|149066508|gb|EDM16381.1|",194,{"v":7e-16,"d":"7.00E-16"},"rCG63686 [Rattus norvegicus]","gi|672067765|ref|XM_008767789.1|",155,{"v":2E-73,"d":"2.00E-73"},"PREDICTED: Rattus norvegicus Rho guanine nucleotide exchange factor (GEF) 15 (Arhgef15), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam12974","Phosphonate-bd","ABC transporter, phosphonate, periplasmic substrate-binding protein. This is a family of periplasmic proteins which are part of the transport system for alkylphosphonate uptake.",".",".",".",".","."]
["ENSRNOG00000069883",17,1.411453229,5,0.321652191,4.388134975,2.133607903,0.001431745,0.001368624,"up","yes","ENSRNOG00000069883","lncRNA","chr19:39024185-39027888:-","gi|672031272|ref|XP_008772457.1|",518,{"v":7e-59,"d":"7.00E-59"},"PREDICTED: heterogeneous nuclear ribonucleoprotein C-like 1 isoform X3 [Rattus norvegicus]","gi|255004822|gb|AC111287.5|",1397,0,"Rattus norvegicus CH230-55H2 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam15240","Pro-rich","Proline-rich. This family includes several eukaryotic proline-rich proteins.",".",".",".",".","."]
["ENSRNOG00000011994",20,1.66053321,7,0.450313067,3.687508383,1.882646329,1.437883E-3,0.001374081,"up","yes","Perp","protein_coding","chr1:13542067-13554511:+","gi|157820213|ref|NP_001099735.1|",943,{"v":6e-121,"d":"6.00E-121"},"p53 apoptosis effector related to PMP-22 [Rattus norvegicus]","gi|186910194|ref|NM_001106265.2|",1869,0,"Rattus norvegicus PERP, TP53 apoptosis effector (Perp), mRNA","Q9JK95",355,{"v":7e-118,"d":"7.00E-118"},"p53 apoptosis effector related to PMP-22",".",".",".",".","pfam13903","Claudin_2","PMP-22/EMP/MP20/Claudin tight junction. Members of this family are claudins, that form tight junctions between cells.","GO:0002934|desmosome organization;GO:0007219|Notch signaling pathway;GO:0034113|heterotypic cell-cell adhesion;GO:0045862|positive regulation of proteolysis;GO:0072332|intrinsic apoptotic signaling pathway by p53 class mediator;GO:0097186|amelogenesis;GO:0097202|activation of cysteine-type endopeptidase activity;GO:0098609|cell-cell adhesion;","GO:0005739|mitochondrion;GO:0005794|Golgi apparatus;GO:0005887|integral component of plasma membrane;GO:0005911|cell-cell junction;",".","K10136","PERP; TP53 apoptosis effector"]
["ENSRNOG00000047295",48,3.985279705,30,1.929913146,2.065004694,1.046145061,0.001516886,1.443967E-3,"up","yes","Prr22","protein_coding","chr9:1599148-1601416:+","gi|564366893|ref|XP_006244400.1|",1505,0,"PREDICTED: proline-rich protein 22 isoform X1 [Rattus norvegicus]","gi|672063984|ref|XM_006244338.2|",1439,0,"PREDICTED: Rattus norvegicus proline rich 22 (Prr22), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam03154","Atrophin-1","Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.",".",".",".",".","."]
["ENSRNOG00000011702",28,2.324746495,13,0.836295696,2.779814012,1.47498836,1.521426E-3,0.001447995,"up","yes","ENSRNOG00000011702","protein_coding","chrX:14908494-14923838:-","gi|157818139|ref|NP_001101720.1|",1749,0,"forkhead box protein P3 [Rattus norvegicus]","gi|157818138|ref|NM_001108250.1|",3185,0,"Rattus norvegicus forkhead box P3 (Foxp3), mRNA","Q99JB6",645,0,"Forkhead box protein P3","YCR065w",83.2,{"v":2e-15,"d":"2.00E-15"},"COG5025","pfam00250","Fork_head","Fork head domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001782|B cell homeostasis;GO:0001818|negative regulation of cytokine production;GO:0002262|myeloid cell homeostasis;GO:0002361|CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0002456|T cell mediated immunity;GO:0002507|tolerance induction;GO:0002513|tolerance induction to self antigen;GO:0002637|regulation of immunoglobulin production;GO:0002666|positive regulation of T cell tolerance induction;GO:0002667|regulation of T cell anergy;GO:0002669|positive regulation of T cell anergy;GO:0002677|negative regulation of chronic inflammatory response;GO:0002725|negative regulation of T cell cytokine production;GO:0002851|positive regulation of peripheral T cell tolerance induction;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008285|negative regulation of cell proliferation;GO:0009314|response to radiation;GO:0009615|response to virus;GO:0010467|gene expression;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0014045|establishment of endothelial blood-brain barrier;GO:0031064|negative regulation of histone deacetylation;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0032496|response to lipopolysaccharide;GO:0032689|negative regulation of interferon-gamma production;GO:0032693|negative regulation of interleukin-10 production;GO:0032700|negative regulation of interleukin-17 production;GO:0032703|negative regulation of interleukin-2 production;GO:0032713|negative regulation of interleukin-4 production;GO:0032714|negative regulation of interleukin-5 production;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032753|positive regulation of interleukin-4 production;GO:0032792|negative regulation of CREB transcription factor activity;GO:0032831|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0032914|positive regulation of transforming growth factor beta1 production;GO:0033092|positive regulation of immature T cell proliferation in thymus;GO:0035066|positive regulation of histone acetylation;GO:0035067|negative regulation of histone acetylation;GO:0042110|T cell activation;GO:0042130|negative regulation of T cell proliferation;GO:0043433|negative regulation of DNA-binding transcription factor activity;GO:0045591|positive regulation of regulatory T cell differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048294|negative regulation of isotype switching to IgE isotypes;GO:0048302|regulation of isotype switching to IgG isotypes;GO:0050672|negative regulation of lymphocyte proliferation;GO:0050687|negative regulation of defense response to virus;GO:0050728|negative regulation of inflammatory response;GO:0050777|negative regulation of immune response;GO:0050852|T cell receptor signaling pathway;GO:1901355|response to rapamycin;GO:2000320|negative regulation of T-helper 17 cell differentiation;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0003714|transcription corepressor activity;GO:0035035|histone acetyltransferase binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0042826|histone deacetylase binding;GO:0043565|sequence-specific DNA binding;GO:0046872|metal ion binding;GO:0051525|NFAT protein binding;GO:1990837|sequence-specific double-stranded DNA binding;","K10163","FOXP3, IPEX; forkhead box P3"]
["ENSRNOG00000019257",24,1.992639853,10,0.643304382,3.097507041,1.631107562,1.580805E-3,0.001497456,"up","yes","Kif27","protein_coding","chr17:6299569-6369768:+","gi|38016129|ref|NP_932167.1|",6748,0,"kinesin-like protein KIF27 [Rattus norvegicus]","gi|38016128|ref|NM_198050.1|",4468,0,"Rattus norvegicus kinesin family member 27 (Kif27), mRNA","Q7M6Z5",2603,0,"Kinesin-like protein KIF27","YGL216w",263,{"v":2e-72,"d":"2.00E-72"},"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0003351|epithelial cilium movement;GO:0007018|microtubule-based movement;GO:0021591|ventricular system development;GO:0060271|cilium assembly;","GO:0005576|extracellular region;GO:0005737|cytoplasm;GO:0005871|kinesin complex;GO:0005874|microtubule;GO:0005929|cilium;","GO:0003777|microtubule motor activity;GO:0005524|ATP binding;GO:0008017|microtubule binding;GO:0016887|ATPase activity;","K24186","KIF27; kinesin family member 27"]
["ENSRNOG00000007573",34,2.822906458,18,1.157947887,2.437852764,1.285610996,0.001650631,0.001558291,"up","yes","Hoxb9","protein_coding","chr10:81237312-81240818:+","gi|113680760|ref|NP_032296.2|",1262,{"v":6e-173,"d":"6.00E-173"},"homeobox protein Hox-B9 [Mus musculus]","gi|154756739|ref|NM_001100497.1|",937,0,"Rattus norvegicus homeo box B9 (Hoxb9), mRNA","P20615",490,{"v":2E-174,"d":"2.00E-174"},"Homeobox protein Hox-B9",".",".",".",".","pfam04617","Hox9_act","Hox9 activation region. This family constitutes the N termini of the paralogous homeobox proteins HoxA9, HoxB9, HoxC9 and HoxD9. The N terminal region is found to act as a transcription activation region. Btg1 and Btg2 - the B-cell translocation gene products - may function as cofactors for Hoxb9-mediated transcription. The Btg proteins modulate Hoxb9 transcriptional activity by recruiting a multiprotein Ccr4-like complex.","GO:0006351|transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0009952|anterior/posterior pattern specification;GO:0009954|proximal/distal pattern formation;GO:0030879|mammary gland development;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048704|embryonic skeletal system morphogenesis;GO:0048706|embryonic skeletal system development;GO:0060326|cell chemotaxis;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0090575|RNA polymerase II transcription factor complex;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:1990837|sequence-specific double-stranded DNA binding;","K09294","HOX_9; homeobox protein HoxB/C/D9"]
["ENSRNOG00000016782",34,2.822906458,18,1.157947887,2.437852764,1.285610996,0.001650631,0.001558291,"up","yes","Tnfrsf8","protein_coding","chr5:157123185-157168421:-","gi|149024572|gb|EDL81069.1|",2447,0,"rCG30864, isoform CRA_b [Rattus norvegicus]","gi|9507192|ref|NM_019135.1|",3289,0,"Rattus norvegicus tumor necrosis factor receptor superfamily, member 8 (Tnfrsf8), mRNA","P97525",899,0,"Tumor necrosis factor receptor superfamily member 8",".",".",".",".","pfam00020","TNFR_c6","TNFR/NGFR cysteine-rich region.","GO:0007165|signal transduction;GO:0032759|positive regulation of TRAIL production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0043065|positive regulation of apoptotic process;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0071260|cellular response to mechanical stimulus;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0004888|transmembrane signaling receptor activity;","K05145","TNFRSF8, CD30; tumor necrosis factor receptor superfamily member 8"]
["ENSRNOG00000010423",21,1.743559871,8,0.514643505,3.387898327,1.760390579,0.00181494,0.001700852,"up","yes","Misp","protein_coding","chr7:9870444-9886541:-","gi|157817426|ref|NP_001102754.1|",3033,0,"mitotic interactor and substrate of PLK1 [Rattus norvegicus]","gi|157817425|ref|NM_001109284.1|",2571,0,"Rattus norvegicus mitotic spindle positioning (Misp), mRNA","Q9D279",993,0,"Mitotic interactor and substrate of PLK1",".",".",".",".","pfam15304","AKAP2_C","A-kinase anchor protein 2 C-terminus. This family includes the C-terminus of A-kinase anchor protein 2 (AKAP2). It includes the site where the regulatory subunits (RII) of protein kinase AII binds.","GO:0000132|establishment of mitotic spindle orientation;GO:0016477|cell migration;GO:0051640|organelle localization;GO:0051660|establishment of centrosome localization;GO:0090307|mitotic spindle assembly;GO:1904776|regulation of protein localization to cell cortex;","GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0005925|focal adhesion;GO:0030864|cortical actin cytoskeleton;GO:0031616|spindle pole centrosome;GO:0043231|intracellular membrane-bounded organelle;GO:1905721|mitotic spindle astral microtubule end;","GO:0051015|actin filament binding;",".","."]
["ENSRNOG00000013380",21,1.743559871,8,0.514643505,3.387898327,1.760390579,0.00181494,0.001700852,"up","yes","Rhov","protein_coding","chr3:106260776-106269479:-","gi|404312692|ref|NP_612551.2|",1278,{"v":7e-171,"d":"7.00E-171"},"rho-related GTP-binding protein RhoV [Rattus norvegicus]","gi|56799423|ref|NM_138542.2|",1713,0,"Rattus norvegicus ras homolog family member V (Rhov), mRNA","Q9Z1Y0",425,{"v":5e-145,"d":"5.00E-145"},"Rho-related GTP-binding protein RhoV",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0006897|endocytosis;GO:0007165|signal transduction;GO:0007264|small GTPase mediated signal transduction;GO:0016477|cell migration;GO:0030031|cell projection assembly;GO:0032488|Cdc42 protein signal transduction;","GO:0005886|plasma membrane;GO:0010008|endosome membrane;","GO:0003924|GTPase activity;GO:0005515|protein binding;GO:0005525|GTP binding;GO:0046872|metal ion binding;","K07866","RHOV, WRCH2; Ras homolog gene family, member V"]
["ENSRNOG00000068566",21,1.743559871,8,0.514643505,3.387898327,1.760390579,0.00181494,0.001700852,"up","yes","Msx1","pseudogene","chr14:72961148-72964966:+","gi|149047351|gb|EDM00021.1|",1060,{"v":3e-137,"d":"3.00E-137"},"homeo box, msh-like 1, isoform CRA_b [Rattus norvegicus]","gi|13592000|ref|NM_031059.1|",1644,0,"Rattus norvegicus msh homeobox 1 (Msx1), mRNA","P13297",412,{"v":1e-138,"d":"1.00E-138"},"Homeobox protein MSX-1",".",".",".",".","pfam00046","Homeobox","Homeobox domain.",".",".",".",".","."]
["ENSRNOG00000050670",15,1.245399908,4,0.257321753,4.839854752,2.274963752,0.001833783,0.001717001,"up","yes","L1td1","protein_coding","chr5:113379870-113385730:+","gi|880903732|ref|XP_012971938.1|",2555,0,"PREDICTED: LINE-1 type transposase domain-containing protein 1 [Mesocricetus auratus]","gi|124487094|ref|NM_001081202.1|",1299,0,"Mus musculus LINE-1 type transposase domain containing 1 (L1td1), mRNA","Q587J6",615,0,"LINE-1 type transposase domain-containing protein 1",".",".",".",".","pfam02994","Transposase_22","L1 transposable element.",".","GO:0043231|intracellular membrane-bounded organelle;",".",".","."]
["ENSRNOG00000030452",25,2.075666513,11,0.70763482,2.933245304,1.552497727,0.001862882,1.740814E-3,"up","yes","Rimbp3","protein_coding","chr11:83784244-83789082:-","gi|34869949|ref|XP_221302.2|",7111,0,"PREDICTED: RIMS-binding protein 3C [Rattus norvegicus]","gi|672026320|ref|XM_001064091.5|",4839,0,"PREDICTED: Rattus norvegicus RIMS binding protein 3 (Rimbp3), mRNA","Q3V0F0",2473,0,"RIMS-binding protein 3",".",".",".",".","pfam14604","SH3_9","Variant SH3 domain.","GO:0007286|spermatid development;GO:0009566|fertilization;","GO:0002177|manchette;GO:0005634|nucleus;","GO:0030156|benzodiazepine receptor binding;",".","."]
["ENSRNOG00000048275",25,2.075666513,11,0.70763482,2.933245304,1.552497727,0.001862882,1.740814E-3,"up","yes","RGD1309350","protein_coding","chr1:195905763-195909159:+","gi|197381585|ref|NP_001127979.1|",752,{"v":9e-98,"d":"9.00E-98"},"5-hydroxyisourate hydrolase [Rattus norvegicus]","gi|197381584|ref|NM_001134507.1|",839,0,"Rattus norvegicus similar to transthyretin (4L369) (RGD1309350), mRNA","Q9CRB3",235,{"v":2e-76,"d":"2.00E-76"},"5-hydroxyisourate hydrolase","AGc4223",97.1,{"v":6e-24,"d":"6.00E-24"},"COG2351","pfam00576","Transthyretin","HIUase/Transthyretin family. This family includes transthyretin that is a thyroid hormone-binding protein that transports thyroxine from the bloodstream to the brain. However, most of the sequences listed in this family do not bind thyroid hormones. They are actually enzymes of the purine catabolism that catalyse the conversion of 5-hydroxyisourate (HIU) to OHCU. HIU hydrolysis is the original function of the family and is conserved from bacteria to mammals; transthyretins arose by gene duplications in the vertebrate lineage. HIUases are distinguished in the alignment from the conserved C-terminal YRGS sequence.","GO:0006144|purine nucleobase metabolic process;",".","GO:0033971|hydroxyisourate hydrolase activity;","K07127","uraH, pucM, hiuH; 5-hydroxyisourate hydrolase [EC:3.5.2.17]"]
["ENSRNOG00000020355",30,2.490799816,15,0.964956573,2.581255868,1.368073156,1.929451E-3,0.001799724,"up","yes","Twist2","protein_coding","chr9:92374574-92419222:+","gi|6681177|ref|NP_031881.1|",842,{"v":1E-108,"d":"1.00E-108"},"twist-related protein 2 [Mus musculus]","gi|158186714|ref|NM_021691.2|",1183,0,"Rattus norvegicus twist family bHLH transcription factor 2 (Twist2), mRNA","P97831",328,{"v":5E-110,"d":"5.00E-110"},"Twist-related protein 2",".",".",".",".","pfam00010","HLH","Helix-loop-helix DNA-binding domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001649|osteoblast differentiation;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008285|negative regulation of cell proliferation;GO:0010838|positive regulation of keratinocyte proliferation;GO:0030335|positive regulation of cell migration;GO:0032502|developmental process;GO:0032720|negative regulation of tumor necrosis factor production;GO:0043066|negative regulation of apoptotic process;GO:0043392|negative regulation of DNA binding;GO:0044092|negative regulation of molecular function;GO:0045638|negative regulation of myeloid cell differentiation;GO:0045668|negative regulation of osteoblast differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0048701|embryonic cranial skeleton morphogenesis;GO:0060325|face morphogenesis;GO:0061303|cornea development in camera-type eye;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005730|nucleolus;GO:0005737|cytoplasm;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003682|chromatin binding;GO:0003700|DNA-binding transcription factor activity;GO:0019904|protein domain specific binding;GO:0046983|protein dimerization activity;","K09069","TWIST; twist"]
["ENSRNOG00000018215",18,1.494479889,6,0.385982629,3.871883802,1.953035657,0.001945627,0.001813225,"up","yes","Slc22a6","protein_coding","chr1:205522729-205531173:+","gi|8393886|ref|NP_058920.1|",2855,0,"solute carrier family 22 member 6 [Rattus norvegicus]","gi|2361034|dbj|AB004559.1|",2209,0,"Rattus norvegicus mRNA for multispecific organic anion transporter, complete cds","O35956",1101,0,"Solute carrier family 22 member 6",".",".",".",".","pfam00083","Sugar_tr","Sugar (and other) transporter.","GO:0006820|anion transport;GO:0015698|inorganic anion transport;GO:0015711|organic anion transport;GO:0015742|alpha-ketoglutarate transport;GO:0031427|response to methotrexate;GO:0043252|sodium-independent organic anion transport;GO:0097254|renal tubular secretion;GO:0098656|anion transmembrane transport;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005901|caveola;GO:0016323|basolateral plasma membrane;GO:0032991|protein-containing complex;","GO:0005452|inorganic anion exchanger activity;GO:0005515|protein binding;GO:0008514|organic anion transmembrane transporter activity;GO:0015301|anion:anion antiporter activity;GO:0015347|sodium-independent organic anion transmembrane transporter activity;GO:0031404|chloride ion binding;GO:0042802|identical protein binding;","K08203","SLC22A6, OAT1; MFS transporter, OCT family, solute carrier family 22 (organic anion transporter), member 6"]
["ENSRNOG00000027468",18,1.494479889,6,0.385982629,3.871883802,1.953035657,0.001945627,0.001813225,"up","yes","Slc6a15","protein_coding","chr7:38553196-38607239:+","gi|27229292|ref|NP_758824.1|",3555,0,"sodium-dependent neutral amino acid transporter B(0)AT2 [Rattus norvegicus]","gi|27229291|ref|NM_172321.1|",3468,0,"Rattus norvegicus solute carrier family 6 member 15 (Slc6a15), mRNA","Q08469",1373,0,"Sodium-dependent neutral amino acid transporter B(0)AT2","VC2012",117,{"v":2e-26,"d":"2.00E-26"},"COG0733","pfam00209","SNF","Sodium:neurotransmitter symporter family.","GO:0003333|amino acid transmembrane transport;GO:0006836|neurotransmitter transport;GO:0015804|neutral amino acid transport;GO:0015820|leucine transport;GO:0015824|proline transport;GO:0035725|sodium ion transmembrane transport;","GO:0005887|integral component of plasma membrane;","GO:0005298|proline:sodium symporter activity;","K05048","SLC6A15S; solute carrier family 6 (neurotransmitter transporter, amino acid/orphan) member 15/16/17/18/20"]
["ENSRNOG00000067467",18,1.494479889,6,0.385982629,3.871883802,1.953035657,0.001945627,0.001813225,"up","yes","ENSRNOG00000067467","lncRNA","chr7:95712385-95760528:-",".",".",".",".","gi|84875700|gb|AC174724.3|",897,0,"Mus musculus BAC clone RP23-101A6 from chromosome 15, complete sequence",".",".",".",".",".",".",".",".","pfam00003","7tm_3","7 transmembrane sweet-taste receptor of 3 GCPR. This is a domain of seven transmembrane regions that forms the C-terminus of some subclass 3 G-coupled-protein receptors. It is often associated with a downstream cysteine-rich linker domain, NCD3G pfam07562, which is the human sweet-taste receptor, and the N-terminal domain, ANF_receptor pfam01094. The seven TM regions assemble in such a way as to produce a docking pocket into which such molecules as cyclamate and lactisole have been found to bind and consequently confer the taste of sweetness.",".",".",".",".","."]
["ENSRNOG00000018285",37,3.071986439,21,1.350939202,2.273963503,1.185209099,0.002073832,0.001921504,"up","yes","Kcna2","protein_coding","chr2:194704639-194718400:+","gi|25742772|ref|NP_037102.1|",2344,0,"potassium voltage-gated channel subfamily A member 2 [Rattus norvegicus]","gi|672043687|ref|XM_006233132.2|",11833,0,"PREDICTED: Rattus norvegicus potassium voltage-gated channel, shaker-related subfamily, member 2 (Kcna2), transcript variant X1, mRNA","P63142",907,0,"Potassium voltage-gated channel subfamily A member 2","DR0830",67.4,{"v":1E-10,"d":"1.00E-10"},"COG1226","pfam02214","BTB_2","BTB/POZ domain. In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.","GO:0014059|regulation of dopamine secretion;GO:0019228|neuronal action potential;GO:0019233|sensory perception of pain;GO:0021633|optic nerve structural organization;GO:0034765|regulation of ion transmembrane transport;GO:0045188|regulation of circadian sleep/wake cycle, non-REM sleep;GO:0051260|protein homooligomerization;GO:0071805|potassium ion transmembrane transport;GO:0097623|potassium ion export across plasma membrane;","GO:0005768|endosome;GO:0005789|endoplasmic reticulum membrane;GO:0005887|integral component of plasma membrane;GO:0008076|voltage-gated potassium channel complex;GO:0016021|integral component of membrane;GO:0030027|lamellipodium;GO:0030424|axon;GO:0030425|dendrite;GO:0031258|lamellipodium membrane;GO:0032809|neuronal cell body membrane;GO:0033010|paranodal junction;GO:0034705|potassium channel complex;GO:0043204|perikaryon;GO:0043679|axon terminus;GO:0044224|juxtaparanode region of axon;GO:0044305|calyx of Held;GO:0099056|integral component of presynaptic membrane;","GO:0005249|voltage-gated potassium channel activity;GO:0005251|delayed rectifier potassium channel activity;GO:0005515|protein binding;GO:0015271|outward rectifier potassium channel activity;GO:0019894|kinesin binding;","K04875","KCNA2, KV1.2; potassium voltage-gated channel Shaker-related subfamily A member 2"]
["ENSRNOG00000061579",37,3.071986439,21,1.350939202,2.273963503,1.185209099,0.002073832,0.001921504,"up","yes","Rpl12-ps1","protein_coding","chr8:79059459-79060213:+","gi|594103046|ref|XP_006074559.1|",987,{"v":1e-132,"d":"1.00E-132"},"PREDICTED: 60S ribosomal protein L12 [Bubalus bubalis]","gi|751662876|ref|NG_041833.1|",755,0,"Rattus norvegicus ribosomal protein L12, pseudogene 1 (Rpl12-ps1) on chromosome 8","P23358",332,{"v":2e-114,"d":"2.00E-114"},"60S ribosomal protein L12","SPCC31H12.04c",254,{"v":2e-84,"d":"2.00E-84"},"COG0080","pfam03946","Ribosomal_L11_N","Ribosomal protein L11, N-terminal domain. The N-terminal domain of Ribosomal protein L11 adopts an alpha/beta fold and is followed by the RNA binding C-terminal domain.",".",".",".",".","."]
["ENSRNOG00000024824",31,2.573826476,16,1.029287011,2.500591622,1.322269467,0.00213427,0.001970649,"up","yes","Col22a1","protein_coding","chr7:103731037-103968462:-","gi|293348732|ref|XP_001072793.2|",3582,0,"PREDICTED: collagen alpha-1(XXII) chain isoform X1 [Rattus norvegicus]","gi|672021956|ref|XM_001072793.5|",6085,0,"PREDICTED: Rattus norvegicus collagen, type XXII, alpha 1 (Col22a1), transcript variant X1, mRNA","Q8NFW1",991,0,"Collagen alpha-1(XXII) chain",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0001525|angiogenesis;GO:0001886|endothelial cell morphogenesis;GO:0030198|extracellular matrix organization;","GO:0005581|collagen trimer;GO:0005615|extracellular space;GO:0031012|extracellular matrix;","GO:0005201|extracellular matrix structural constituent;","K16630","COL22A; collagen type XXII alpha"]
["ENSRNOG00000011196",13,1.079346587,3,0.192991315,5.592721047,2.483550374,0.002255863,0.002074234,"up","yes","Krt25","protein_coding","chr10:84267399-84274965:-","gi|57012370|ref|NP_001008822.1|",2026,0,"keratin, type I cytoskeletal 25 [Rattus norvegicus]","gi|57012369|ref|NM_001008822.1|",819,0,"Rattus norvegicus keratin 25, type I (Krt25), mRNA","Q6IFX0",785,0,"Keratin, type I cytoskeletal 25",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0007010|cytoskeleton organization;GO:0007568|aging;GO:0031069|hair follicle morphogenesis;GO:0042633|hair cycle;GO:0045109|intermediate filament organization;","GO:0005737|cytoplasm;GO:0005882|intermediate filament;","GO:0005198|structural molecule activity;GO:0046982|protein heterodimerization activity;","K07604","KRT1; type I keratin, acidic"]
["ENSRNOG00000011598",13,1.079346587,3,0.192991315,5.592721047,2.483550374,0.002255863,0.002074234,"up","yes","ENSRNOG00000011598","protein_coding","chr15:98537641-98582545:-","gi|1136776|dbj|BAA08844.1|",3660,0,"proton-coupled dipeptide cotransporter [Rattus norvegicus]","gi|1136775|dbj|D50306.1|RATPCDC",2854,0,"Rattus norvegicus mRNA for proton-coupled dipeptide cotransporter, complete cds","P51574",1405,0,"Solute carrier family 15 member 1","ECU11g1050",199,{"v":3e-54,"d":"3.00E-54"},"COG3104","pfam00854","PTR2","POT family. The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.","GO:0006857|oligopeptide transport;GO:0015031|protein transport;GO:0051956|negative regulation of amino acid transport;GO:0140206|dipeptide import across plasma membrane;GO:1902600|proton transmembrane transport;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005903|brush border;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;","GO:0005427|proton-dependent oligopeptide secondary active transmembrane transporter activity;GO:0015333|peptide:proton symporter activity;GO:0016248|channel inhibitor activity;GO:0071916|dipeptide transmembrane transporter activity;","K14206","SLC15A1, PEPT1; solute carrier family 15 (oligopeptide transporter), member 1"]
["ENSRNOG00000017381",13,1.079346587,3,0.192991315,5.592721047,2.483550374,0.002255863,0.002074234,"up","yes","Itih4","protein_coding","chr16:6080539-6095708:+","gi|126722991|ref|NP_062242.2|",4701,0,"inter-alpha-trypsin inhibitor heavy chain H4 precursor [Rattus norvegicus]","gi|126722990|ref|NM_019369.2|",2962,0,"Rattus norvegicus inter-alpha-trypsin inhibitor heavy chain family, member 4 (Itih4), mRNA","A6X935",1493,0,"Inter alpha-trypsin inhibitor, heavy chain 4","alr4412",110,{"v":1e-23,"d":"1.00E-23"},"COG2304","pfam08487","VIT","Vault protein inter-alpha-trypsin domain. Inter-alpha-trypsin inhibitors (ITIs) consist of one light chain and a variable set of heavy chains. ITIs play a role in extracellular matrix (ECM) stabilisation and tumor metastasis as well as in plasma protease inhibition. The vault protein inter-alpha-trypsin (VIT) domain described here is found to the N-terminus of a von Willebrand factor type A domain (pfam00092) in ITI heavy chains (ITIHs) and their precursors.","GO:0006953|acute-phase response;GO:0008150|biological_process;GO:0010951|negative regulation of endopeptidase activity;GO:0030212|hyaluronan metabolic process;GO:0034097|response to cytokine;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005886|plasma membrane;","GO:0003674|molecular_function;GO:0004867|serine-type endopeptidase inhibitor activity;","K24514","ITIH4; inter-alpha-trypsin inhibitor heavy chain H4"]
["ENSRNOG00000019118",13,1.079346587,3,0.192991315,5.592721047,2.483550374,0.002255863,0.002074234,"up","yes","Slc13a3","protein_coding","chr3:154141872-154204606:-","gi|162138928|ref|NP_074057.2|",2561,0,"solute carrier family 13 member 3 [Rattus norvegicus]","gi|162138927|ref|NM_022866.2|",3176,0,"Rattus norvegicus solute carrier family 13 member 3 (Slc13a3), mRNA","Q9Z0Z5",988,0,"Solute carrier family 13 member 3","SA1732",204,{"v":4E-55,"d":"4.00E-55"},"COG0471","pfam00939","Na_sulph_symp","Sodium:sulfate symporter transmembrane region. There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.","GO:0006814|sodium ion transport;GO:0006835|dicarboxylic acid transport;GO:0015742|alpha-ketoglutarate transport;GO:0015744|succinate transport;GO:0015746|citrate transport;GO:0015810|aspartate transmembrane transport;GO:0034775|glutathione transmembrane transport;GO:0070778|L-aspartate transmembrane transport;GO:0071422|succinate transmembrane transport;GO:0098656|anion transmembrane transport;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;","GO:0005310|dicarboxylic acid transmembrane transporter activity;GO:0005343|organic acid:sodium symporter activity;GO:0015137|citrate transmembrane transporter activity;GO:0015139|alpha-ketoglutarate transmembrane transporter activity;GO:0015141|succinate transmembrane transporter activity;GO:0015183|L-aspartate transmembrane transporter activity;GO:0015362|high-affinity sodium:dicarboxylate symporter activity;GO:0017153|sodium:dicarboxylate symporter activity;GO:0034634|glutathione transmembrane transporter activity;","K14445","SLC13A2_3_5; solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2/3/5"]
["ENSRNOG00000031397",32,2.656853137,17,1.093617449,2.429417287,1.280610315,2.337549E-3,0.002143794,"up","yes","Stk32b","protein_coding","chr14:73078061-73336458:+","gi|157821711|ref|NP_001100694.1|",2162,0,"serine/threonine-protein kinase 32B [Rattus norvegicus]","gi|255003773|ref|NM_022416.2|",1448,0,"Mus musculus serine/threonine kinase 32B (Stk32b), mRNA","Q9JJX8",821,0,"Serine/threonine-protein kinase 32B",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0018105|peptidyl-serine phosphorylation;GO:0035556|intracellular signal transduction;",".","GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;","K08793","STK32, YANK; serine/threonine kinase 32 [EC:2.7.11.1]"]
["ENSRNOG00000038473",32,2.656853137,17,1.093617449,2.429417287,1.280610315,2.337549E-3,0.002143794,"up","yes","Got1l1","protein_coding","chr16:64860704-64866162:+","gi|564389575|ref|XP_006253353.1|",2118,0,"PREDICTED: putative aspartate aminotransferase, cytoplasmic 2 isoform X1 [Rattus norvegicus]","gi|62078734|ref|NM_001014003.1|",1424,0,"Rattus norvegicus glutamic-oxaloacetic transaminase 1-like 1 (Got1l1), mRNA","Q7TSV6",758,0,"Putative aspartate aminotransferase, cytoplasmic 2","SPAC10F6.13c",207,{"v":2e-60,"d":"2.00E-60"},"COG1448","pfam00155","Aminotran_1_2","Aminotransferase class I and II.","GO:0006532|aspartate biosynthetic process;","GO:0005829|cytosol;","GO:0004069|L-aspartate:2-oxoglutarate aminotransferase activity;GO:0030170|pyridoxal phosphate binding;",".","."]
["ENSRNOG00000008065",39,3.23803976,23,1.479600078,2.188456062,1.129913419,2.341545E-3,0.002146535,"up","yes","Wwc1","protein_coding","chr10:20300833-20454497:-","gi|109490515|ref|XP_001066364.1|",4631,0,"PREDICTED: protein KIBRA isoform X1 [Rattus norvegicus]","gi|672067111|ref|XM_002727761.4|",3873,0,"PREDICTED: Rattus norvegicus WW and C2 domain containing 1 (Wwc1), transcript variant X1, mRNA","Q5SXA9",1736,0,"Protein KIBRA","SPBC16E9.11c",70.9,{"v":2e-11,"d":"2.00E-11"},"COG5021","pfam00397","WW","WW domain. The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006355|regulation of transcription, DNA-templated;GO:0016477|cell migration;GO:0035330|regulation of hippo signaling;GO:0035331|negative regulation of hippo signaling;GO:0043410|positive regulation of MAPK cascade;GO:0045893|positive regulation of transcription, DNA-templated;GO:0046621|negative regulation of organ growth;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0032587|ruffle membrane;GO:0032991|protein-containing complex;GO:0048471|perinuclear region of cytoplasm;","GO:0003713|transcription coactivator activity;GO:0019900|kinase binding;GO:0030674|protein binding, bridging;GO:0060090|molecular adaptor activity;","K16685","WWC1; protein KIBRA"]
["ENSRNOG00000037835",39,3.23803976,23,1.479600078,2.188456062,1.129913419,2.341545E-3,0.002146535,"up","yes","Catip","protein_coding","chr9:75945961-75953607:+","gi|564311783|ref|XP_002727288.2|",1887,0,"PREDICTED: ciliogenesis-associated TTC17-interacting protein isoform X1 [Rattus norvegicus]","gi|672024167|ref|XM_008758058.1|",1791,0,"PREDICTED: Rattus norvegicus hypothetical protein LOC690437 (LOC690437), transcript variant X4, mRNA","M0RAU5",665,0,"Ciliogenesis-associated TTC17-interacting protein",".",".",".",".","pfam07415","Herpes_LMP2","Gammaherpesvirus latent membrane protein (LMP2) protein. This family consists of several Gammaherpesvirus latent membrane protein (LMP2) proteins. Epstein-Barr virus is a human Gammaherpesvirus that infects and establishes latency in B lymphocytes in vivo. The latent membrane protein 2 (LMP2) gene is expressed in latently infected B cells and encodes two protein isoforms, LMP2A and LMP2B, that are identical except for an additional N-terminal 119 aa cytoplasmic domain which is present in the LMP2A isoform. LMP2A is thought to play a key role in either the establishment or the maintenance of latency and/or the reactivation of productive infection from the latent state. The significance of LMP2B and its role in pathogenesis remain unclear.","GO:0030041|actin filament polymerization;GO:0044782|cilium organization;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0015629|actin cytoskeleton;",".",".","."]
["ENSRNOG00000003807",8,0.664213284,0,0.032165219,20.65004694,4.368073156,0.002365571,0.002163288,"up","yes","Wnt9b","protein_coding","chr10:88635331-88657035:-","gi|880882276|ref|XP_005070115.2|",1611,0,"PREDICTED: protein Wnt-9b [Mesocricetus auratus]","gi|157820440|ref|NM_001107055.1|",4650,0,"Rattus norvegicus wingless-type MMTV integration site family, member 9B (Wnt9b), mRNA","O35468",603,0,"Protein Wnt-9b",".",".",".",".","pfam00110","wnt","wnt family. Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.","GO:0001658|branching involved in ureteric bud morphogenesis;GO:0001701|in utero embryonic development;GO:0001822|kidney development;GO:0001932|regulation of protein phosphorylation;GO:0003339|regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0008150|biological_process;GO:0009267|cellular response to starvation;GO:0009786|regulation of asymmetric cell division;GO:0016055|Wnt signaling pathway;GO:0030182|neuron differentiation;GO:0030539|male genitalia development;GO:0035150|regulation of tube size;GO:0043085|positive regulation of catalytic activity;GO:0045165|cell fate commitment;GO:0048701|embryonic cranial skeleton morphogenesis;GO:0048754|branching morphogenesis of an epithelial tube;GO:0060021|roof of mouth development;GO:0060070|canonical Wnt signaling pathway;GO:0060071|Wnt signaling pathway, planar cell polarity pathway;GO:0060993|kidney morphogenesis;GO:0061038|uterus morphogenesis;GO:0072003|kidney rudiment formation;GO:0072038|mesenchymal stem cell maintenance involved in nephron morphogenesis;GO:0072044|collecting duct development;GO:0072046|establishment of planar polarity involved in nephron morphogenesis;GO:0072078|nephron tubule morphogenesis;GO:0072164|mesonephric tubule development;GO:0072170|metanephric tubule development;GO:0072174|metanephric tubule formation;GO:0072181|mesonephric duct formation;GO:1902455|negative regulation of stem cell population maintenance;GO:1904948|midbrain dopaminergic neuron differentiation;GO:1905438|non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation;","GO:0005575|cellular_component;GO:0005615|extracellular space;","GO:0003674|molecular_function;GO:0005102|signaling receptor binding;GO:0005109|frizzled binding;GO:0005125|cytokine activity;GO:0039706|co-receptor binding;GO:0048018|receptor ligand activity;","K01064","WNT9; wingless-type MMTV integration site family, member 9"]
["ENSRNOG00000019687",8,0.664213284,0,0.032165219,20.65004694,4.368073156,0.002365571,0.002163288,"up","yes","Art2b","protein_coding","chr1:155956603-155974253:-","gi|672037762|ref|XP_008757924.1|",1427,{"v":1e-178,"d":"1.00E-178"},"PREDICTED: T-cell ecto-ADP-ribosyltransferase 2 isoform X8 [Rattus norvegicus]","gi|12055486|emb|AJ297708.1|",4478,0,"Rattus norvegicus RT6 gene for T cell differentiation marker RT6.2, exons 1-8","P20974",532,{"v":2e-172,"d":"2.00E-172"},"T-cell ecto-ADP-ribosyltransferase 2",".",".",".",".","pfam01129","ART","NAD:arginine ADP-ribosyltransferase.","GO:0006471|protein ADP-ribosylation;GO:0018120|peptidyl-arginine ADP-ribosylation;GO:0019677|NAD catabolic process;","GO:0031362|anchored component of external side of plasma membrane;GO:0046658|anchored component of plasma membrane;","GO:0003950|NAD+ ADP-ribosyltransferase activity;GO:0003956|NAD(P)+-protein-arginine ADP-ribosyltransferase activity;GO:0016798|hydrolase activity, acting on glycosyl bonds;GO:0061810|NAD glycohydrolase activity;","K19980","ART2, RT6; ADP-ribosyltransferase 2 / NAD+ glycohydrolase [EC:2.4.2.31 3.2.2.5]"]
["ENSRNOG00000021401",8,0.664213284,0,0.032165219,20.65004694,4.368073156,0.002365571,0.002163288,"up","yes","Lpar5","protein_coding","chr4:157881796-157882950:+","gi|293347056|ref|XP_001063300.2|",1487,0,"PREDICTED: lysophosphatidic acid receptor 5 [Rattus norvegicus]","gi|672018723|ref|XM_008775838.1|",1155,0,"PREDICTED: Rattus norvegicus lysophosphatidic acid receptor 5 (Lpar5), transcript variant X8, mRNA","Q149R9",483,{"v":2e-168,"d":"2.00E-168"},"Lysophosphatidic acid receptor 5",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0032793|positive regulation of CREB transcription factor activity;GO:0048266|behavioral response to pain;","GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;","K08390","LPAR5, GPR92; lysophosphatidic acid receptor 5"]
["ENSRNOG00000028598",8,0.664213284,0,0.032165219,20.65004694,4.368073156,0.002365571,0.002163288,"up","yes","Edar","protein_coding","chr20:26587839-26666494:-","gi|568966645|ref|XP_006513269.1|",2036,0,"PREDICTED: tumor necrosis factor receptor superfamily member EDAR isoform X3 [Mus musculus]","gi|672086280|ref|XM_006256381.2|",3625,0,"PREDICTED: Rattus norvegicus ectodysplasin-A receptor (Edar), transcript variant X1, mRNA","Q9R187",777,0,"Tumor necrosis factor receptor superfamily member EDAR",".",".",".",".","pfam00531","Death","Death domain.","GO:0001942|hair follicle development;GO:0008150|biological_process;GO:0010628|positive regulation of gene expression;GO:0042475|odontogenesis of dentin-containing tooth;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043473|pigmentation;GO:0046330|positive regulation of JNK cascade;GO:0060662|salivary gland cavitation;GO:1901224|positive regulation of NIK/NF-kappaB signaling;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0045177|apical part of cell;","GO:0003674|molecular_function;GO:0004888|transmembrane signaling receptor activity;GO:0038023|signaling receptor activity;","K05162","EDAR; tumor necrosis factor receptor superfamily member EDAR"]
["ENSRNOG00000040120",8,0.664213284,0,0.032165219,20.65004694,4.368073156,0.002365571,0.002163288,"up","yes","Bhmt2","protein_coding","chr2:24895533-24912475:-","gi|158081741|ref|NP_001014278.2|",1764,0,"S-methylmethionine--homocysteine S-methyltransferase BHMT2 [Rattus norvegicus]","gi|158081740|ref|NM_001014256.2|",1966,0,"Rattus norvegicus betaine-homocysteine S-methyltransferase 2 (Bhmt2), mRNA","Q68FT5",681,0,"S-methylmethionine--homocysteine S-methyltransferase BHMT2","BS_yitJ_1",80.1,{"v":1e-15,"d":"1.00E-15"},"COG0646","pfam02574","S-methyl_trans","Homocysteine S-methyltransferase. This is a family of related homocysteine S-methyltransferases enzymes: 5-methyltetrahydrofolate--homocysteine S-methyltransferases also known EC:2.1.1.13; Betaine--homocysteine S-methyltransferase (vitamin B12 dependent), EC:2.1.1.5,; and Homocysteine S-methyltransferase, EC:2.1.1.10,.","GO:0032259|methylation;GO:0033477|S-methylmethionine metabolic process;GO:0046500|S-adenosylmethionine metabolic process;GO:0071267|L-methionine salvage;",".","GO:0008270|zinc ion binding;GO:0047150|betaine-homocysteine S-methyltransferase activity;GO:0061627|S-methylmethionine-homocysteine S-methyltransferase activity;","K00547","mmuM, BHMT2; homocysteine S-methyltransferase [EC:2.1.1.10]"]
["ENSRNOG00000042251",8,0.664213284,0,0.032165219,20.65004694,4.368073156,0.002365571,0.002163288,"up","yes","AABR07030771.1","protein_coding","chr10:100083490-100115821:-","gi|392351722|ref|XP_002727887.2|",1551,0,"PREDICTED: CMRF35-like molecule 5 isoform X3 [Rattus norvegicus]","gi|564375262|ref|XM_002727841.3|",1399,0,"PREDICTED: Rattus norvegicus Cd300 molecule-like family member D (Cd300ld), transcript variant X3, mRNA","Q6SJQ5",221,{"v":6e-67,"d":"6.00E-67"},"CMRF35-like molecule 3",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000045908",8,0.664213284,0,0.032165219,20.65004694,4.368073156,0.002365571,0.002163288,"up","yes","AABR07044416.1","protein_coding","chr20:4760118-4770244:-","gi|672085585|ref|XP_006255978.2|",1221,{"v":4E-160,"d":"4.00E-160"},"PREDICTED: RT1 class II, locus Ha isoform X1 [Rattus norvegicus]","gi|672085584|ref|XM_006255916.2|",1414,0,"PREDICTED: Rattus norvegicus RT1 class II, locus Ha (RT1-Ha), transcript variant X1, mRNA","P20755",290,{"v":3e-91,"d":"3.00E-91"},"RLA class II histocompatibility antigen, DP alpha-1 chain (Fragment)",".",".",".",".","pfam00993","MHC_II_alpha","Class II histocompatibility antigen, alpha domain.",".",".",".",".","."]
["ENSRNOG00000047730",8,0.664213284,0,0.032165219,20.65004694,4.368073156,0.002365571,0.002163288,"up","yes","Tnfsf14","protein_coding","chr9:2069104-2073216:-","gi|972854014|tpe|CTQ86172.1|",1463,0,"TPA: tumor necrosis factor ligand 1d [Rattus norvegicus]","gi|972854013|tpe|LN874407.1|",936,0,"TPA_inf: Rattus norvegicus mRNA for tumor necrosis factor ligand 1d (Tnlg1d gene)","Q9QYH9",444,{"v":6e-155,"d":"6.00E-155"},"Tumor necrosis factor ligand superfamily member 14",".",".",".",".","pfam00229","TNF","TNF(tumor Necrosis Factor) family.","GO:0006915|apoptotic process;GO:0006955|immune response;GO:0010820|positive regulation of T cell chemotaxis;GO:0031295|T cell costimulation;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045663|positive regulation of myoblast differentiation;GO:0071260|cellular response to mechanical stimulus;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1901741|positive regulation of myoblast fusion;","GO:0016021|integral component of membrane;","GO:0005102|signaling receptor binding;GO:0005164|tumor necrosis factor receptor binding;GO:0042802|identical protein binding;GO:0043027|cysteine-type endopeptidase inhibitor activity involved in apoptotic process;","K05477","TNFSF14, LIGHT, CD258; tumor necrosis factor ligand superfamily member 14"]
["ENSRNOG00000054548",8,0.664213284,0,0.032165219,20.65004694,4.368073156,0.002365571,0.002163288,"up","yes","Srpk3","protein_coding","chrX:151510539-151515198:+","gi|564329376|ref|XP_006229623.1|",2509,0,"PREDICTED: SRSF protein kinase 3 isoform X4 [Rattus norvegicus]","gi|672088923|ref|XM_006229561.2|",2074,0,"PREDICTED: Rattus norvegicus SRSF protein kinase 3 (Srpk3), transcript variant X4, mRNA","Q9Z0G2",910,0,"SRSF protein kinase 3",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006468|protein phosphorylation;GO:0007519|skeletal muscle tissue development;GO:0060537|muscle tissue development;",".","GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;","K08832","SRPK3, STK23; serine/threonine-protein kinase SRPK3 [EC:2.7.11.1]"]
["ENSRNOG00000065386",8,0.664213284,0,0.032165219,20.65004694,4.368073156,0.002365571,0.002163288,"up","yes","ENSRNOG00000065386","lncRNA","chr14:72102856-72106598:-","gi|929218267|ref|XP_013985279.1|",194,{"v":6e-13,"d":"6.00E-13"},"PREDICTED: FRAS1-related extracellular matrix protein 2-like [Salmo salar]",".",".",".",".",".",".",".",".",".",".",".",".","pfam05287","PMG","PMG protein. This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteristic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.",".",".",".",".","."]
["ENSRNOG00000066387",8,0.664213284,0,0.032165219,20.65004694,4.368073156,0.002365571,0.002163288,"up","yes","Ly49i5","protein_coding","chr4:163983732-164009424:-","gi|57222334|ref|NP_001009501.1|",1362,0,"Ly49 inhibitory receptor 5 [Rattus norvegicus]","gi|61889122|ref|NM_001009501.2|",1398,0,"Rattus norvegicus Ly49 inhibitory receptor 5 (Ly49i5), mRNA","Q60652",251,{"v":3e-78,"d":"3.00E-78"},"Killer cell lectin-like receptor 5",".",".",".",".","pfam08391","Ly49","Ly49-like protein, N-terminal region. The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).",".",".",".",".","."]
["ENSRNOG00000070055",8,0.664213284,0,0.032165219,20.65004694,4.368073156,0.002365571,0.002163288,"up","yes","ENSRNOG00000070055","protein_coding","chr17:42696791-42697295:+","gi|392354394|ref|XP_003751759.1|",550,{"v":3e-69,"d":"3.00E-69"},"PREDICTED: histone H2A type 1-like [Rattus norvegicus]","gi|672082126|ref|XM_003751711.3|",505,0,"PREDICTED: Rattus norvegicus histone H2A type 1-like (LOC100910554), transcript variant X2, mRNA","Q4FZT6",211,{"v":2e-68,"d":"2.00E-68"},"Histone H2A type 3","SPAC19G12.06c",177,{"v":7e-56,"d":"7.00E-56"},"COG5262","pfam00125","Histone","Core histone H2A/H2B/H3/H4.",".",".",".",".","."]
["ENSRNOG00000055197",27,2.241719834,13,0.836295696,2.68053494,1.42252094,0.002444657,2.228598E-3,"up","yes","AABR07027872.1","protein_coding","chr17:45680483-45686011:-","gi|2118701|pir||JC4683",802,{"v":7E-105,"d":"7.00E-105"},"T-cell receptor gamma chain C region - rat","gi|1359459|dbj|D55648.1|RATTCRGC",628,0,"Rattus sp. mRNA for T-cell receptor gamma chain, complete cds","P06334",214,{"v":6E-68,"d":"6.00E-68"},"T-cell receptor gamma chain C region DFL12",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.",".",".",".",".","."]
["ENSRNOG00000071190",40,3.321066421,24,1.543930516,2.151046557,1.10503875,0.002469606,2.248777E-3,"up","yes","Pspn","protein_coding","chr9:1840896-1854327:-","gi|56090552|ref|NP_001007712.1|",1745,0,"general transcription factor IIF subunit 1 [Rattus norvegicus]","gi|672063948|ref|XM_006244321.2|",1801,0,"PREDICTED: Rattus norvegicus general transcription factor IIF, polypeptide 1 (Gtf2f1), transcript variant X1, mRNA","Q6AY96",676,0,"General transcription factor IIF subunit 1",".",".",".",".","pfam05793","TFIIF_alpha","Transcription initiation factor IIF, alpha subunit (TFIIF-alpha). Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) or RNA polymerase II-associating protein 74 (RAP74) is the large subunit of transcription factor IIF (TFIIF), which is essential for accurate initiation and stimulates elongation by RNA polymerase II.",".",".",".",".","."]
["ENSRNOG00000011132",19,1.57750655,7,0.450313067,3.503132964,1.808645748,0.002505648,0.002279649,"up","yes","ENSRNOG00000011132","protein_coding","chr3:90510942-90781894:-","gi|672017116|ref|XP_008773686.1|",9360,0,"PREDICTED: UPF0606 protein KIAA1549L homolog isoform X1 [Rattus norvegicus]","gi|755499614|ref|XM_006499483.2|",5602,0,"PREDICTED: Mus musculus RIKEN cDNA D430041D05 gene (D430041D05Rik), transcript variant X3, mRNA","Q6ZVL6",2361,0,"UPF0606 protein KIAA1549L",".",".",".",".","pfam12877","DUF3827","Domain of unknown function (DUF3827). This family contains the human KIAA1549 protein which has been found to be fused fused to BRAF gene in many cases of pilocytic astrocytomas. The fusion is due mainly to a tandem duplication of 2 Mb at 7q34. Although nothing is known about the function of KIAA1549 protein, the BRAF protein is a well characterized oncoprotein. It is a serine/threonine protein kinase which is implicated in MAP/ERK signalling, a critical pathway for the regulation of cell division, differentiation and secretion.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000018366",19,1.57750655,7,0.450313067,3.503132964,1.808645748,0.002505648,0.002279649,"up","yes","Cracdl","protein_coding","chr9:39834833-39951086:-","gi|564311478|ref|XP_006226868.1|",5362,0,"PREDICTED: uncharacterized protein KIAA1211-like homolog isoform X3 [Rattus norvegicus]","gi|672023934|ref|XM_006226804.2|",3511,0,"PREDICTED: Rattus norvegicus similar to putative protein (5S487) (RGD1310819), transcript variant X7, mRNA",".",".",".",".",".",".",".",".","pfam15262","DUF4592","Domain of unknown function (DUF4592). This protein family is a domain of unknown function, which lies to the N-terminus of the protein. This domain family is found in eukaryotes, and is typically between 114 and 130 amino acids in length. There are two completely conserved residues (L and A) that may be functionally important. In humans, the gene that encodes this protein lies in the position, chromosome 2 open reading frame 55.",".",".",".",".","."]
["ENSRNOG00000027331",19,1.57750655,7,0.450313067,3.503132964,1.808645748,0.002505648,0.002279649,"up","yes","Ppef1","protein_coding","chrX:34021350-34151701:+","gi|77917564|ref|NP_001030107.1|",3295,0,"serine/threonine-protein phosphatase with EF-hands 1 [Rattus norvegicus]","gi|77917563|ref|NM_001034935.1|",2284,0,"Rattus norvegicus protein phosphatase with EF-hand domain 1 (Ppef1), mRNA","Q3SWT6",1271,0,"Serine/threonine-protein phosphatase with EF-hands 1","SPBC3F6.01c_2",190,{"v":1E-52,"d":"1.00E-52"},"COG0639","pfam00149","Metallophos","Calcineurin-like phosphoesterase. This family includes a diverse range of phosphoesterases, including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD or yeast MRE11. The most conserved regions in this superfamily centre around the metal chelating residues.","GO:0006470|protein dephosphorylation;GO:0050906|detection of stimulus involved in sensory perception;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004722|protein serine/threonine phosphatase activity;GO:0005506|iron ion binding;GO:0005509|calcium ion binding;GO:0030145|manganese ion binding;","K13807","PPEF, PPP7C; serine/threonine-protein phosphatase with EF-hands [EC:3.1.3.16]"]
["ENSRNOG00000004327",33,2.739879797,18,1.157947887,2.366151212,1.242542274,0.002537995,2.30547E-3,"up","yes","Ddc","protein_coding","chr14:86378685-86469208:-","gi|564384864|ref|XP_006251536.1|",2566,0,"PREDICTED: aromatic-L-amino-acid decarboxylase isoform X3 [Rattus norvegicus]","gi|399498499|ref|NM_001270852.1|",5094,0,"Rattus norvegicus dopa decarboxylase (Ddc), transcript variant 3, mRNA","P14173",968,0,"Aromatic-L-amino-acid decarboxylase","mll0712",311,{"v":5e-92,"d":"5.00E-92"},"COG0076","pfam00282","Pyridoxal_deC","Pyridoxal-dependent decarboxylase conserved domain.","GO:0006520|cellular amino acid metabolic process;GO:0006584|catecholamine metabolic process;GO:0007623|circadian rhythm;GO:0009636|response to toxic substance;GO:0010259|multicellular organism aging;GO:0015842|aminergic neurotransmitter loading into synaptic vesicle;GO:0033076|isoquinoline alkaloid metabolic process;GO:0042416|dopamine biosynthetic process;GO:0042417|dopamine metabolic process;GO:0042423|catecholamine biosynthetic process;GO:0042427|serotonin biosynthetic process;GO:0046684|response to pyrethroid;GO:0052314|phytoalexin metabolic process;GO:0071312|cellular response to alkaloid;GO:0071363|cellular response to growth factor stimulus;GO:0071466|cellular response to xenobiotic stimulus;","GO:0005737|cytoplasm;GO:0008021|synaptic vesicle;GO:0030424|axon;GO:0043025|neuronal cell body;","GO:0004058|aromatic-L-amino-acid decarboxylase activity;GO:0005515|protein binding;GO:0016597|amino acid binding;GO:0016831|carboxy-lyase activity;GO:0019899|enzyme binding;GO:0019904|protein domain specific binding;GO:0030170|pyridoxal phosphate binding;GO:0036467|5-hydroxy-L-tryptophan decarboxylase activity;GO:0036468|L-dopa decarboxylase activity;","K01593","DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase [EC:4.1.1.28 4.1.1.105]"]
["ENSRNOG00000008575",9,0.747239945,1,0.064330438,11.61565141,3.537998158,0.002563714,0.002325529,"up","yes","Aoc1","protein_coding","chr4:77812260-77831840:+","gi|144226253|ref|NP_075224.2|",3982,0,"amiloride-sensitive amine oxidase [copper-containing] precursor [Rattus norvegicus]","gi|144226252|ref|NM_022935.2|",2764,0,"Rattus norvegicus amine oxidase, copper containing 1 (Aoc1), mRNA","P36633",1527,0,"Amiloride-sensitive amine oxidase [copper-containing]","tynA",130,{"v":4e-30,"d":"4.00E-30"},"COG3733","pfam01179","Cu_amine_oxid","Copper amine oxidase, enzyme domain. Copper amine oxidases are a ubiquitous and novel group of quinoenzymes that catalyse the oxidative deamination of primary amines to the corresponding aldehydes, with concomitant reduction of molecular oxygen to hydrogen peroxide. The enzymes are dimers of identical 70-90 kDa subunits, each of which contains a single copper ion and a covalently bound cofactor formed by the post-translational modification of a tyrosine side chain to 2,4,5-trihydroxyphenylalanine quinone (TPQ). This family corresponds to the catalytic domain of the enzyme.","GO:0008150|biological_process;GO:0009308|amine metabolic process;GO:0009445|putrescine metabolic process;GO:0015898|amiloride transport;GO:0035874|cellular response to copper ion starvation;GO:0046677|response to antibiotic;GO:0071280|cellular response to copper ion;GO:0071420|cellular response to histamine;GO:0097185|cellular response to azide;","GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0005923|bicellular tight junction;GO:0070062|extracellular exosome;","GO:0005507|copper ion binding;GO:0005509|calcium ion binding;GO:0008131|primary amine oxidase activity;GO:0008201|heparin binding;GO:0008270|zinc ion binding;GO:0042803|protein homodimerization activity;GO:0044877|protein-containing complex binding;GO:0048038|quinone binding;GO:0052597|diamine oxidase activity;GO:0052598|histamine oxidase activity;GO:0052599|methylputrescine oxidase activity;GO:0052600|propane-1,3-diamine oxidase activity;GO:0097159|organic cyclic compound binding;","K11182","AOC1, ABP1; diamine oxidase [EC:1.4.3.22]"]
["ENSRNOG00000010315",9,0.747239945,1,0.064330438,11.61565141,3.537998158,0.002563714,0.002325529,"up","yes","Ccr4","protein_coding","chr8:114176974-114178056:-","gi|149018350|gb|EDL76991.1|",1740,0,"rCG25460 [Rattus norvegicus]","gi|672063364|ref|XM_006243915.2|",1083,0,"PREDICTED: Rattus norvegicus chemokine (C-C motif) receptor 4 (Ccr4), transcript variant X1, mRNA","P51680",654,0,"C-C chemokine receptor type 4",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001764|neuron migration;GO:0002507|tolerance induction;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0009314|response to radiation;GO:0009617|response to bacterium;GO:0019722|calcium-mediated signaling;GO:0046677|response to antibiotic;GO:0048872|homeostasis of number of cells;GO:0050927|positive regulation of positive chemotaxis;GO:0060326|cell chemotaxis;GO:0070098|chemokine-mediated signaling pathway;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0043025|neuronal cell body;","GO:0003674|molecular_function;GO:0016493|C-C chemokine receptor activity;GO:0019957|C-C chemokine binding;","K04179","CCR4, CD194; C-C chemokine receptor type 4"]
["ENSRNOG00000019685",9,0.747239945,1,0.064330438,11.61565141,3.537998158,0.002563714,0.002325529,"up","yes","Gdpd3","protein_coding","chr1:181366626-181383063:+","gi|115311606|sp|P21708.5|MK03_RAT",1876,0,"RecName: Full=Mitogen-activated protein kinase 3; Short=MAP kinase 3; Short=MAPK 3; AltName: Full=ERT2; AltName: Full=Extracellular signal-regulated kinase 1; Short=ERK-1; AltName: Full=Insulin-stimulated MAP2 kinase; AltName: Full=MAP kinase isoform p44; Short=p44-MAPK; AltName: Full=MNK1; AltName: Full=Microtubule-associated protein 2 kinase; AltName: Full=p44-ERK1","gi|68537200|ref|NM_017347.2|",1736,0,"Rattus norvegicus mitogen activated protein kinase 3 (Mapk3), mRNA","P21708",727,0,"Mitogen-activated protein kinase 3",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006644|phospholipid metabolic process;GO:0034638|phosphatidylcholine catabolic process;GO:0046475|glycerophospholipid catabolic process;GO:0070291|N-acylethanolamine metabolic process;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0048471|perinuclear region of cytoplasm;","GO:0004622|lysophospholipase activity;GO:0008081|phosphoric diester hydrolase activity;","K22387","GDPD1_3, GDE4_7; lysophospholipase D [EC:3.1.4.39]"]
["ENSRNOG00000021924",9,0.747239945,1,0.064330438,11.61565141,3.537998158,0.002563714,0.002325529,"up","yes","Cyp2c22","protein_coding","chr1:238991610-239021738:-","gi|117236|sp|P19225.1|CP270_RAT",2626,0,"RecName: Full=Cytochrome P450 2C70; AltName: Full=CYPIIC70; AltName: Full=Cytochrome P-450Md; AltName: Full=Cytochrome P450 P49","gi|298901220|emb|FQ218628.1|",1798,0,"Rattus norvegicus TL0ABA50YN15 mRNA sequence","P19225",1016,0,"Cytochrome P450 2C70","BH0579",102,{"v":3e-22,"d":"3.00E-22"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0006082|organic acid metabolic process;GO:0006805|xenobiotic metabolic process;GO:0019373|epoxygenase P450 pathway;GO:0042178|xenobiotic catabolic process;","GO:0005737|cytoplasm;GO:0005789|endoplasmic reticulum membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0004497|monooxygenase activity;GO:0005506|iron ion binding;GO:0008392|arachidonic acid epoxygenase activity;GO:0008395|steroid hydroxylase activity;GO:0016712|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0020037|heme binding;","K07413","CYP2C; cytochrome P450 family 2 subfamily C [EC:1.14.14.1]"]
["ENSRNOG00000048771",9,0.747239945,1,0.064330438,11.61565141,3.537998158,0.002563714,0.002325529,"up","yes","RGD1559482","protein_coding","chr10:100136867-100140427:+","gi|293340561|ref|XP_001081656.2|",1068,{"v":3e-144,"d":"3.00E-144"},"PREDICTED: CMRF35-like molecule isoform X1 [Rattus norvegicus]","gi|672070031|ref|XM_577143.5|",869,0,"PREDICTED: Rattus norvegicus similar to leukocyte mono-Ig-like receptor2 (RGD1562667), transcript variant X1, mRNA","Q7TSN2",271,{"v":8e-89,"d":"8.00E-89"},"CMRF35-like molecule",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004888|transmembrane signaling receptor activity;","K06719","CD300; CD300 antigen"]
["ENSRNOG00000055996",9,0.747239945,1,0.064330438,11.61565141,3.537998158,0.002563714,0.002325529,"up","yes","AABR07006032.1","protein_coding","chr1:196864336-196896475:+","gi|11138240|dbj|BAB17787.1|",8898,0,"mucin [Rattus norvegicus]","gi|11138239|dbj|AB042530.1|",5530,0,"Rattus norvegicus Muc5AC mRNA for mucin, partial cds","P98088",2423,0,"Mucin-5AC",".",".",".",".","pfam00094","VWD","von Willebrand factor type D domain. Luciferin-2-monooxygenase from Vargula hilgendorfii contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.",".",".",".",".","."]
["ENSRNOG00000004380",11,0.913293266,2,0.128660876,7.098453637,2.827504775,0.002581918,0.002339091,"up","yes","Il12b","protein_coding","chr10:28893008-28902903:+","gi|564371446|ref|XP_006246209.1|",1687,0,"PREDICTED: interleukin-12 subunit beta isoform X1 [Rattus norvegicus]","gi|735997433|ref|NM_001303244.1|",1098,0,"Mus musculus interleukin 12b (Il12b), mRNA","P43432",598,0,"Interleukin-12 subunit beta",".",".",".",".","pfam10420","IL12p40_C","Cytokine interleukin-12p40 C-terminus. IL12p40_C is the largely beta stranded C-terminal, D3, domain of interleukin-12p40 or interleukin-12B. This interleukin is produced on stimulation by macrophage-engulfed micro-organisms and other stimuli, when it dimerises with interleukin-12p35 to form a heterodimer which then binds to receptors on natural killer cells to activate them to destroy the micro-organisms. This domain contains two disulfide bridges, one of which serves to bind p40 to p35 and the other to hold the beta strands within the domain together. The cupped shape of the p35 binding interface matches the elbow-like bend between D2 and D3 in p40. The domain is often associated with family fn3, pfam00041.","GO:0001916|positive regulation of T cell mediated cytotoxicity;GO:0002230|positive regulation of defense response to virus by host;GO:0002323|natural killer cell activation involved in immune response;GO:0002827|positive regulation of T-helper 1 type immune response;GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target;GO:0002862|negative regulation of inflammatory response to antigenic stimulus;GO:0007166|cell surface receptor signaling pathway;GO:0008283|cell proliferation;GO:0010033|response to organic substance;GO:0010224|response to UV-B;GO:0010536|positive regulation of activation of Janus kinase activity;GO:0016477|cell migration;GO:0019221|cytokine-mediated signaling pathway;GO:0019233|sensory perception of pain;GO:0030101|natural killer cell activation;GO:0032693|negative regulation of interleukin-10 production;GO:0032700|negative regulation of interleukin-17 production;GO:0032725|positive regulation of granulocyte macrophage colony-stimulating factor production;GO:0032729|positive regulation of interferon-gamma production;GO:0032733|positive regulation of interleukin-10 production;GO:0032735|positive regulation of interleukin-12 production;GO:0032740|positive regulation of interleukin-17 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032816|positive regulation of natural killer cell activation;GO:0032819|positive regulation of natural killer cell proliferation;GO:0032946|positive regulation of mononuclear cell proliferation;GO:0034393|positive regulation of smooth muscle cell apoptotic process;GO:0042093|T-helper cell differentiation;GO:0042102|positive regulation of T cell proliferation;GO:0042104|positive regulation of activated T cell proliferation;GO:0042509|regulation of tyrosine phosphorylation of STAT protein;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0042832|defense response to protozoan;GO:0045672|positive regulation of osteoclast differentiation;GO:0045785|positive regulation of cell adhesion;GO:0048662|negative regulation of smooth muscle cell proliferation;GO:0050671|positive regulation of lymphocyte proliferation;GO:0050709|negative regulation of protein secretion;GO:0050829|defense response to Gram-negative bacterium;GO:0051135|positive regulation of NK T cell activation;GO:0051142|positive regulation of NK T cell proliferation;GO:0051607|defense response to virus;GO:0051726|regulation of cell cycle;GO:0071222|cellular response to lipopolysaccharide;GO:0071346|cellular response to interferon-gamma;GO:1900747|negative regulation of vascular endothelial growth factor signaling pathway;GO:1903588|negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0043235|receptor complex;GO:0043514|interleukin-12 complex;GO:0070743|interleukin-23 complex;","GO:0004896|cytokine receptor activity;GO:0005125|cytokine activity;GO:0005126|cytokine receptor binding;GO:0008083|growth factor activity;GO:0019955|cytokine binding;GO:0042164|interleukin-12 alpha subunit binding;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;GO:0045519|interleukin-23 receptor binding;GO:0046982|protein heterodimerization activity;","K05425","IL12B; interleukin 12B"]
["ENSRNOG00000030541",11,0.913293266,2,0.128660876,7.098453637,2.827504775,0.002581918,0.002339091,"up","yes","Ccdc154","protein_coding","chr10:14177278-14187253:+","gi|672024599|ref|XP_008772921.1|",3256,0,"PREDICTED: coiled-coil domain-containing protein 154 [Rattus norvegicus]","gi|672024598|ref|XM_008774699.1|",2631,0,"PREDICTED: Rattus norvegicus coiled-coil domain containing 154 (Ccdc154), mRNA","Q6RUT8",1036,0,"Coiled-coil domain-containing protein 154",".",".",".",".","pfam15450","DUF4631","Domain of unknown function (DUF4631). This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 394 and 668 amino acids in length.","GO:0035630|bone mineralization involved in bone maturation;GO:0042475|odontogenesis of dentin-containing tooth;GO:0044691|tooth eruption;GO:0045453|bone resorption;",".",".",".","."]
["ENSRNOG00000069592",11,0.913293266,2,0.128660876,7.098453637,2.827504775,0.002581918,0.002339091,"up","yes","ENSRNOG00000069592","lncRNA","chr10:80634842-80649380:-","gi|26352193|dbj|BAC39733.1|",361,{"v":2e-36,"d":"2.00E-36"},"unnamed protein product [Mus musculus]","gi|644990248|tpe|HG981183.1|",755,0,"TPA: Mus musculus long non-coding RNA OTTMUST00000120316.1 (RP23-17C2.4 gene), lincRNA",".",".",".",".",".",".",".",".","pfam09606","Med15","ARC105 or Med15 subunit of Mediator complex non-fungal. The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.",".",".",".",".","."]
["ENSRNOG00000069611",11,0.913293266,2,0.128660876,7.098453637,2.827504775,0.002581918,0.002339091,"up","yes","ENSRNOG00000069611","lncRNA","chr3:15802470-15822182:-",".",".",".",".","gi|26984852|emb|AL928710.6|",437,0,"Mouse DNA sequence from clone RP23-255P20 on chromosome 2, complete sequence",".",".",".",".",".",".",".",".","pfam12968","DUF3856","Domain of Unknown Function (DUF3856). TPR-like protein. The 2hr2 structure belongs to the SCOP all alpha class, TPR-like superfamily, CT2138-like family. A DALI search gives hits with the putative peptidyl-prolyl isomerase 2fbn (Z=16), the SGTA protein (Z=16), the PLCR protein 2qfc (Z=16), a putative FK506-binding protein (PDB:1qz2-A; DALI Z-score 15.3; RMSD 2.9; 16% sequence identity within 132 superimposed residues), and with the tetratricopeptide repeats of the protein phosphatase 5 (PDB:2bug; DALI Z-score 15.1; RMSD 2.5; 19% sequence identity within 117 superimposed residues).",".",".",".",".","."]
["ENSRNOG00000068149",41,3.404093082,25,1.608260955,2.116629812,1.081768971,2.59334E-3,2.348405E-3,"up","yes","ENSRNOG00000068149","lncRNA","chr18:31235874-31237913:+",".",".",".",".","gi|672083164|ref|XM_006254663.2|",2040,0,"PREDICTED: Rattus norvegicus Rho GTPase activating protein 26 (Arhgap26), transcript variant X4, mRNA",".",".",".",".",".",".",".",".","pfam05024","Gpi1","N-acetylglucosaminyl transferase component (Gpi1). Glycosylphosphatidylinositol (GPI) represents an important anchoring molecule for cell surface proteins.The first step in its synthesis is the transfer of N-acetylglucosamine (GlcNAc) from UDP-N-acetylglucosamine to phosphatidylinositol (PI). This chemically simple step is genetically complex because three or four genes are required in both yeast (GPI1, GPI2 and GPI3) and mammals (GPI1, PIG A, PIG H and PIG C), respectively.",".",".",".",".","."]
["ENSRNOG00000000825",16,1.328426568,5,0.321652191,4.130009389,2.046145061,0.002599683,0.002352483,"up","yes","Calhm5","protein_coding","chr20:26066242-26072272:-","gi|68163381|ref|NP_001020148.1|",1650,0,"protein FAM26E [Rattus norvegicus]","gi|68163380|ref|NM_001024977.1|",1024,0,"Rattus norvegicus family with sequence similarity 26, member E (Fam26e), mRNA","Q5FWS4",640,0,"Calcium homeostasis modulator protein 5",".",".",".",".","pfam14798","Ca_hom_mod","Calcium homeostasis modulator. This family of proteins control cytosolic calcium concentration. They are transmembrane proteins which may be pore-forming ion channels.","GO:0098655|cation transmembrane transport;","GO:0005887|integral component of plasma membrane;","GO:0005261|cation channel activity;",".","."]
["ENSRNOG00000021159",16,1.328426568,5,0.321652191,4.130009389,2.046145061,0.002599683,0.002352483,"up","yes","ENSRNOG00000021159","protein_coding","chr9:1154987-1155443:+","gi|293349609|ref|XP_002727201.1|",380,{"v":6e-45,"d":"6.00E-45"},"PREDICTED: 40S ribosomal protein S27-like [Rattus norvegicus]","gi|298915980|emb|FQ222911.1|",310,{"v":4E-160,"d":"4.00E-160"},"Rattus norvegicus TL0ADA17YP11 mRNA sequence","Q71TY3",143,{"v":2e-43,"d":"2.00E-43"},"40S ribosomal protein S27","SPBC1685.10",111,{"v":1e-31,"d":"1.00E-31"},"COG2051","pfam01667","Ribosomal_S27e","Ribosomal protein S27.","GO:0000028|ribosomal small subunit assembly;GO:0006412|translation;","GO:0022627|cytosolic small ribosomal subunit;","GO:0003723|RNA binding;GO:0003735|structural constituent of ribosome;","K02978","RP-S27e, RPS27; small subunit ribosomal protein S27e"]
["ENSRNOG00000050941",16,1.328426568,5,0.321652191,4.130009389,2.046145061,0.002599683,0.002352483,"up","yes","Olr1587","protein_coding","chr13:86075557-86076495:+","gi|47576435|ref|NP_001000913.1|",1629,0,"olfactory receptor Olr1587 [Rattus norvegicus]","gi|672074952|ref|XM_008769793.1|",939,0,"PREDICTED: Rattus norvegicus olfactory receptor 1587 (Olr1587), transcript variant X3, mRNA","Q96KK4",253,{"v":2e-80,"d":"2.00E-80"},"Olfactory receptor 10C1",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0050911|detection of chemical stimulus involved in sensory perception of smell;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004984|olfactory receptor activity;GO:0005549|odorant binding;","K04257","OLFR; olfactory receptor"]
["ENSRNOG00000061376",16,1.328426568,5,0.321652191,4.130009389,2.046145061,0.002599683,0.002352483,"up","yes","Psca","protein_coding","chr7:106595284-106609746:+","gi|285403261|ref|NP_001165577.1|",443,{"v":4e-49,"d":"4.00E-49"},"prostate stem cell antigen precursor [Rattus norvegicus]","gi|56090358|ref|NM_001007658.1|",939,0,"Rattus norvegicus thioesterase superfamily member 6 (Them6), mRNA","P57096",153,{"v":1E-42,"d":"1.00E-42"},"Prostate stem cell antigen",".",".",".",".","pfam00021","UPAR_LY6","u-PAR/Ly-6 domain. This extracellular disulphide bond rich domain is related to pfam00087.",".",".",".",".","."]
["ENSRNOG00000068899",23,1.909613192,10,0.643304382,2.968444248,1.569707017,2.627009E-3,0.002376538,"up","yes","ENSRNOG00000068899","lncRNA","chr10:11752664-11763054:+","gi|640824451|ref|XP_008069296.1|",380,{"v":1E-59,"d":"1.00E-59"},"PREDICTED: tigger transposable element-derived protein 7 [Tarsius syrichta]","gi|672024537|ref|XR_338462.2|",2543,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102551940 (LOC102551940), ncRNA","Q6NT04",137,{"v":7e-54,"d":"7.00E-54"},"Tigger transposable element-derived protein 7",".",".",".",".","pfam03184","DDE_1","DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. Interestingly this family also includes the CENP-B protein. This domain in that protein appears to have lost the metal binding residues and is unlikely to have endonuclease activity. Centromere Protein B (CENP-B) is a DNA-binding protein localized to the centromere.",".",".",".",".","."]
["ENSRNOG00000064506",34,2.822906458,19,1.222278326,2.309544724,1.207608484,2.734514E-3,2.466813E-3,"up","yes","ENSRNOG00000064506","protein_coding","chr7:12610196-12622587:+","gi|187282338|ref|NP_001119753.1|",2598,0,"zinc finger protein 955A [Rattus norvegicus]","gi|195540031|gb|BC168190.1|",1568,0,"Rattus norvegicus cDNA clone IMAGE:7106560","Q8N972",412,{"v":1E-134,"d":"1.00E-134"},"Zinc finger protein 709",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000070747",34,2.822906458,19,1.222278326,2.309544724,1.207608484,2.734514E-3,2.466813E-3,"up","yes","ENSRNOG00000070747","protein_coding","chr14:43141243-43143223:-","gi|392353121|ref|XP_003751409.1|",1459,0,"PREDICTED: solute carrier family 25 member 51-like isoform X2 [Rattus norvegicus]","gi|672076293|ref|XM_003751363.3|",996,0,"PREDICTED: Rattus norvegicus similar to Mitochondrial carrier triple repeat 1 (RGD1565119), mRNA","Q52KK3",558,0,"Solute carrier family 25 member 51",".",".",".",".","pfam00153","Mito_carr","Mitochondrial carrier protein.",".",".",".",".","."]
["ENSRNOG00000058087",28,2.324746495,14,0.900626135,2.581255868,1.368073156,0.002737828,0.002469454,"up","yes","Lilrc2","protein_coding","chr1:65272796-65277271:-","gi|153945876|ref|NP_001093593.1|",1434,0,"leukocyte immunoglobulin-like receptor, subfamily C, member 2 [Rattus norvegicus]","gi|153945875|ref|NM_001100123.1|",1034,0,"Rattus norvegicus leukocyte immunoglobulin-like receptor, subfamily C, member 2 (Lilrc2), mRNA","A6NI73",281,{"v":1e-90,"d":"1.00E-90"},"Leukocyte immunoglobulin-like receptor subfamily A member 5",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0019221|cytokine-mediated signaling pathway;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0032396|inhibitory MHC class I receptor activity;","K06512","LILR, CD85; leukocyte immunoglobulin-like receptor"]
["ENSRNOG00000024553",43,3.570146403,27,1.736921831,2.055444487,1.039450409,0.002826841,0.002543284,"up","yes","Cyb5d2","protein_coding","chr10:57396765-57413715:-","gi|564372805|ref|XP_006246792.1|",1302,{"v":2E-175,"d":"2.00E-175"},"PREDICTED: neuferricin isoform X1 [Rattus norvegicus]","gi|672067933|ref|XM_006246730.2|",1231,0,"PREDICTED: Rattus norvegicus cytochrome b5 domain containing 2 (Cyb5d2), transcript variant X1, mRNA","Q6AY62",382,{"v":5e-128,"d":"5.00E-128"},"Neuferricin",".",".",".",".","pfam15498","Dendrin","Nephrin and CD2AP-binding protein, Dendrin. Dendrin is a family of eukaryotic proteins found in the podocytes of the kidneys. Dendrin, originally identified in telencephalic dendrites, is a constituent of the slit diaphragm, SD, complex of podocytes, where it directly binds to nephrin and CD2AP. Kidney podocytes and their slit diaphragms (SDs) form the final barrier to urinary protein loss. SD proteins also participate in intracellular signalling pathways. Dendrin appears to prevent programmed cell death (apoptosis) through its binding to nephrin. The SD protein nephrin serves as a component of a signalling complex that directly links podocyte junctional integrity to actin cytoskeletal dynamics. Thus, dendrin is identified as an SD family with proapoptotic signalling properties that accumulates in the podocyte nucleus in response to glomerular injury.","GO:0007399|nervous system development;GO:0045666|positive regulation of neuron differentiation;","GO:0005576|extracellular region;GO:0012505|endomembrane system;GO:0016020|membrane;","GO:0020037|heme binding;",".","."]
["ENSRNOG00000034060",44,3.653173063,28,1.801252269,2.028129611,1.020149853,0.002936256,2.635419E-3,"up","yes","AC119015.3","protein_coding","chr10:73743526-73743822:-","gi|602634398|ref|XP_007424071.1|",340,{"v":9e-39,"d":"9.00E-39"},"PREDICTED: transcription elongation factor B polypeptide 2-like isoform X2 [Python bivittatus]",".",".",".",".","P62870",129,{"v":5e-38,"d":"5.00E-38"},"Elongin-B",".",".",".",".","pfam00240","ubiquitin","Ubiquitin family. This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) Nedd8, Elongin B, Rub1, and Parkin. A number of them are thought to carry a distinctive five-residue motif termed the proteasome-interacting motif (PIM), which may have a biologically significant role in protein delivery to proteasomes and recruitment of proteasomes to transcription sites.",".",".",".",".","."]
["ENSRNOG00000009052",20,1.66053321,8,0.514643505,3.226569835,1.690001251,0.003097001,2.768038E-3,"up","yes","Igf2bp3","protein_coding","chr4:78060494-78194865:-","gi|392339927|ref|XP_003753941.1|",2706,0,"PREDICTED: insulin-like growth factor 2 mRNA-binding protein 3 isoform X1 [Rattus norvegicus]","gi|672018272|ref|XM_003753893.3|",4038,0,"PREDICTED: Rattus norvegicus insulin-like growth factor 2 mRNA binding protein 3 (Igf2bp3), transcript variant X1, mRNA","Q9CPN8",1040,0,"Insulin-like growth factor 2 mRNA-binding protein 3",".",".",".",".","pfam00013","KH_1","KH domain. KH motifs bind RNA in vitro. Autoantibodies to Nova, a KH domain protein, cause paraneoplastic opsoclonus ataxia.","GO:0007399|nervous system development;GO:0010468|regulation of gene expression;GO:0051028|mRNA transport;GO:0051252|regulation of RNA metabolic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0003729|mRNA binding;GO:0003730|mRNA 3'-UTR binding;GO:0048027|mRNA 5'-UTR binding;","K13197","IGF2BP3; insulin-like growth factor 2 mRNA-binding protein 3"]
["ENSRNOG00000068602",20,1.66053321,8,0.514643505,3.226569835,1.690001251,0.003097001,2.768038E-3,"up","yes","ENSRNOG00000068602","protein_coding","chr17:42718263-42722997:+","gi|940774925|ref|XP_014303291.1|",555,{"v":5e-65,"d":"5.00E-65"},"PREDICTED: histone H2A type 1-H isoform X2 [Myotis lucifugus]","gi|672082132|ref|XM_002728479.4|",434,0,"PREDICTED: Rattus norvegicus histone cluster 1, H2ae-like (LOC100360754), transcript variant X2, mRNA","Q4FZT6",215,{"v":1e-65,"d":"1.00E-65"},"Histone H2A type 3","SPAC19G12.06c",179,{"v":8e-53,"d":"8.00E-53"},"COG5262","pfam00125","Histone","Core histone H2A/H2B/H3/H4.",".",".",".",".","."]
["ENSRNOG00000005669",30,2.490799816,16,1.029287011,2.419927376,1.274963752,0.003315702,2.940083E-3,"up","yes","Ca8","protein_coding","chr5:21305383-21402374:-","gi|57527117|ref|NP_001009662.1|",1391,0,"carbonic anhydrase-related protein [Rattus norvegicus]","gi|57527116|ref|NM_001009662.1|",1399,0,"Rattus norvegicus carbonic anhydrase 8 (Car8), mRNA","Q5PPN4",540,0,"Carbonic anhydrase-related protein","BH0360",98.6,{"v":2e-22,"d":"2.00E-22"},"COG3338","pfam00194","Carb_anhydrase","Eukaryotic-type carbonic anhydrase.","GO:0006730|one-carbon metabolic process;GO:0048015|phosphatidylinositol-mediated signaling;","GO:0005737|cytoplasm;","GO:0004089|carbonate dehydratase activity;GO:0008270|zinc ion binding;GO:0016836|hydro-lyase activity;","K01672","CA; carbonic anhydrase [EC:4.2.1.1]"]
["ENSRNOG00000067159",30,2.490799816,16,1.029287011,2.419927376,1.274963752,0.003315702,2.940083E-3,"up","yes","ENSRNOG00000067159","pseudogene","chr6:87354410-87354688:-","gi|451770396|ref|NP_001263412.1|",398,{"v":3e-48,"d":"3.00E-48"},"small integral membrane protein 12 [Rattus norvegicus]","gi|672053852|ref|XM_006238907.2|",156,{"v":1e-74,"d":"1.00E-74"},"PREDICTED: Rattus norvegicus small integral membrane protein 12 (Smim12), transcript variant X1, mRNA","D4ACP2",157,{"v":1e-49,"d":"1.00E-49"},"Small integral membrane protein 12",".",".",".",".","pfam03169","OPT","OPT oligopeptide transporter protein. The OPT family of oligopeptide transporters is distinct from the ABC pfam00005 and PTR pfam00854 transporter families. OPT transporters were first recognized in fungi (Candida albicans and Schizosaccharomyces pombe), but this alignment also includes orthologues from Arabidopsis thaliana. OPT transporters are thought to have 12-14 transmembrane domains and contain the following motif: SPYxEVRxxVxxxDDP.",".",".",".",".","."]
["ENSRNOG00000012008",14,1.162373247,4,0.257321753,4.517197769,2.175428078,3.404607E-3,0.003012234,"up","yes","S100a3","protein_coding","chr2:176049520-176089702:+","gi|564336996|ref|XP_006232620.1|",497,{"v":3e-59,"d":"3.00E-59"},"PREDICTED: protein S100-A3 isoform X2 [Rattus norvegicus]","gi|672042834|ref|XM_006232558.2|",872,0,"PREDICTED: Rattus norvegicus S100 calcium binding protein A3 (S100a3), transcript variant X1, mRNA","P62819",172,{"v":8e-52,"d":"8.00E-52"},"Protein S100-A3",".",".",".",".","pfam01023","S_100","S-100/ICaBP type calcium binding domain. The S-100 domain is a subfamily of the EF-hand calcium binding proteins.",".","GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0005509|calcium ion binding;GO:0008270|zinc ion binding;GO:0048306|calcium-dependent protein binding;","K23760","S100A3, S100E; protein S100-A3"]
["ENSRNOG00000018953",14,1.162373247,4,0.257321753,4.517197769,2.175428078,3.404607E-3,0.003012234,"up","yes","Cblc","protein_coding","chr1:79439977-79456755:-","gi|576011138|sp|G3V8H4.1|CBLC_RAT",2535,0,"RecName: Full=E3 ubiquitin-protein ligase CBL-C","gi|240255493|ref|NM_001034920.2|",1651,0,"Rattus norvegicus Cbl proto-oncogene C, E3 ubiquitin protein ligase (Cblc), mRNA","G3V8H4",959,0,"E3 ubiquitin-protein ligase CBL-C",".",".",".",".","pfam02762","Cbl_N3","CBL proto-oncogene N-terminus, SH2-like domain. Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. The so called N-terminal domain is actually 3 structural domains, of which this is the C-terminal SH2 domain.","GO:0006511|ubiquitin-dependent protein catabolic process;GO:0007165|signal transduction;GO:0007166|cell surface receptor signaling pathway;GO:0007175|negative regulation of epidermal growth factor-activated receptor activity;GO:0016567|protein ubiquitination;GO:0042059|negative regulation of epidermal growth factor receptor signaling pathway;GO:0043407|negative regulation of MAP kinase activity;","GO:0005886|plasma membrane;GO:0045121|membrane raft;","GO:0001784|phosphotyrosine residue binding;GO:0005154|epidermal growth factor receptor binding;GO:0005509|calcium ion binding;GO:0017124|SH3 domain binding;GO:0030971|receptor tyrosine kinase binding;GO:0061630|ubiquitin protein ligase activity;","K22518","CBLC; E3 ubiquitin-protein ligase CBL-C [EC:2.3.2.27]"]
["ENSRNOG00000070878",14,1.162373247,4,0.257321753,4.517197769,2.175428078,3.404607E-3,0.003012234,"up","yes","ENSRNOG00000070878","protein_coding","chr5:110908577-110913310:-","gi|16741207|gb|AAH16446.1|",686,{"v":1e-86,"d":"1.00E-86"},"Cyp2j13 protein [Mus musculus]","gi|755507997|ref|XM_006502937.2|",335,{"v":7e-174,"d":"7.00E-174"},"PREDICTED: Mus musculus cytochrome P450, family 2, subfamily j, polypeptide 13 (Cyp2j13), transcript variant X2, mRNA","P51590",204,{"v":6e-62,"d":"6.00E-62"},"Cytochrome P450 2J3","BH0579",61.6,{"v":6E-11,"d":"6.00E-11"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.",".",".",".",".","."]
["ENSRNOG00000005430",17,1.411453229,6,0.385982629,3.656779146,1.870573497,0.003439229,0.003040341,"up","yes","AABR07040944.1","protein_coding","chrX:107697440-107698439:-","gi|971450487|ref|XP_015129918.1|",351,{"v":6e-40,"d":"6.00E-40"},"PREDICTED: 40S ribosomal protein S19 [Gallus gallus]","gi|672021950|ref|XM_008776477.1|",186,{"v":4e-91,"d":"4.00E-91"},"PREDICTED: Rattus norvegicus ribosomal protein S19-like 1 (Rps19l1), mRNA","Q5R8M9",139,{"v":4E-41,"d":"4.00E-41"},"40S ribosomal protein S19","SPBC649.02",97.1,{"v":2e-25,"d":"2.00E-25"},"COG2238","pfam01090","Ribosomal_S19e","Ribosomal protein S19e.",".",".",".",".","."]
["ENSRNOG00000010210",17,1.411453229,6,0.385982629,3.656779146,1.870573497,0.003439229,0.003040341,"up","yes","Slc7a11","protein_coding","chr2:133963107-134517536:-","gi|164518939|ref|NP_001101143.2|",2514,0,"cystine/glutamate transporter [Rattus norvegicus]","gi|164518938|ref|NM_001107673.2|",2189,0,"Rattus norvegicus solute carrier family 7 member 11 (Slc7a11), mRNA","Q9WTR6",965,0,"Cystine/glutamate transporter","BS_ykbA",157,{"v":2e-39,"d":"2.00E-39"},"COG0531","pfam13520","AA_permease_2","Amino acid permease.","GO:0003333|amino acid transmembrane transport;GO:0006749|glutathione metabolic process;GO:0006979|response to oxidative stress;GO:0007420|brain development;GO:0008542|visual learning;GO:0009636|response to toxic substance;GO:0014070|response to organic cyclic compound;GO:0021591|ventricular system development;GO:0021756|striatum development;GO:0030534|adult behavior;GO:0033029|regulation of neutrophil apoptotic process;GO:0034599|cellular response to oxidative stress;GO:0034775|glutathione transmembrane transport;GO:0035094|response to nicotine;GO:0042127|regulation of cell proliferation;GO:0048021|regulation of melanin biosynthetic process;GO:0048286|lung alveolus development;GO:0050804|modulation of chemical synaptic transmission;GO:0050807|regulation of synapse organization;GO:0051223|regulation of protein transport;GO:0051775|response to redox state;GO:0060173|limb development;GO:0070306|lens fiber cell differentiation;GO:0070527|platelet aggregation;GO:0071702|organic substance transport;GO:0090461|glutamate homeostasis;GO:0098712|L-glutamate import across plasma membrane;GO:0140206|dipeptide import across plasma membrane;GO:1900407|regulation of cellular response to oxidative stress;GO:1901494|regulation of cysteine metabolic process;GO:1903204|negative regulation of oxidative stress-induced neuron death;GO:1903786|regulation of glutathione biosynthetic process;GO:1904717|regulation of AMPA glutamate receptor clustering;GO:2000211|regulation of glutamate metabolic process;","GO:0005791|rough endoplasmic reticulum;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0031526|brush border membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0045177|apical part of cell;GO:0097449|astrocyte projection;","GO:0003674|molecular_function;GO:0015179|L-amino acid transmembrane transporter activity;","K13869","SLC7A11; solute carrier family 7 (L-type amino acid transporter), member 11"]
["ENSRNOG00000064980",17,1.411453229,6,0.385982629,3.656779146,1.870573497,0.003439229,0.003040341,"up","yes","ENSRNOG00000064980","protein_coding","chr1:58416708-58425255:+","gi|755485630|ref|XP_011243774.1|",882,{"v":2E-113,"d":"2.00E-113"},"PREDICTED: zinc finger protein 431-like isoform X1 [Mus musculus]","gi|755546054|ref|XM_006517504.2|",368,0,"PREDICTED: Mus musculus zinc finger protein 431-like (LOC102632416), transcript variant X4, mRNA","E9QAG8",306,{"v":3e-99,"d":"3.00E-99"},"Zinc finger protein 431",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.",".",".",".",".","."]
["ENSRNOG00000065602",38,3.1550131,23,1.479600078,2.132341804,1.092438714,0.003465336,0.003060036,"up","yes","ENSRNOG00000065602","protein_coding","chr2:61543323-61578556:-","gi|84000579|ref|NP_071945.3|",843,{"v":1e-105,"d":"1.00E-105"},"ferritin light chain 1 [Rattus norvegicus]","gi|298890396|emb|FQ234116.1|",1037,0,"Rattus norvegicus TL0AEA5YB23 mRNA sequence","P02793",329,{"v":5e-107,"d":"5.00E-107"},"Ferritin light chain 1",".",".",".",".","pfam00210","Ferritin","Ferritin-like domain. This family contains ferritins and other ferritin-like proteins such as members of the DPS family and bacterioferritins.",".",".",".",".","."]
["ENSRNOG00000063647",31,2.573826476,17,1.093617449,2.353497997,1.234806625,0.003596389,0.003163963,"up","yes","ENSRNOG00000063647","protein_coding","chrX:134320773-134325672:+","gi|537128405|gb|ERE65415.1|",294,{"v":3e-30,"d":"3.00E-30"},"protein DDX26B [Cricetulus griseus]","gi|755490553|ref|XM_006544571.2|",237,{"v":2E-119,"d":"2.00E-119"},"PREDICTED: Mus musculus predicted gene 10477 (Gm10477), mRNA","Q5JSJ4",68.9,{"v":2E-12,"d":"2.00E-12"},"Integrator complex subunit 6-like",".",".",".",".","pfam15300","INT_SG_DDX_CT_C","INTS6/SAGE1/DDX26B/CT45 C-terminus. This domain is found at the C-terminus of integrator complex subunit 6 (INTS6), sarcoma antigen 1 (SAGE1), protein DDX26B (DDX26B) and members of the cancer/testis antigen family 45.",".",".",".",".","."]
["ENSRNOG00000005639",39,3.23803976,24,1.543930516,2.097270393,1.068512874,0.003631468,0.003186495,"up","yes","Ar","protein_coding","chrX:63104771-63273925:+","gi|202968|gb|AAA40759.1|",3924,0,"androgen receptor [Rattus norvegicus]","gi|6978534|ref|NM_012502.1|",4100,0,"Rattus norvegicus androgen receptor (Ar), mRNA","P15207",1513,0,"Androgen receptor",".",".",".",".","pfam02166","Androgen_recep","Androgen receptor.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001701|in utero embryonic development;GO:0003073|regulation of systemic arterial blood pressure;GO:0003382|epithelial cell morphogenesis;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007283|spermatogenesis;GO:0007338|single fertilization;GO:0007620|copulation;GO:0008049|male courtship behavior;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0008584|male gonad development;GO:0009566|fertilization;GO:0009987|cellular process;GO:0010468|regulation of gene expression;GO:0010628|positive regulation of gene expression;GO:0014734|skeletal muscle hypertrophy;GO:0019098|reproductive behavior;GO:0019102|male somatic sex determination;GO:0030518|intracellular steroid hormone receptor signaling pathway;GO:0030520|intracellular estrogen receptor signaling pathway;GO:0030521|androgen receptor signaling pathway;GO:0030522|intracellular receptor signaling pathway;GO:0032355|response to estradiol;GO:0032868|response to insulin;GO:0033148|positive regulation of intracellular estrogen receptor signaling pathway;GO:0033327|Leydig cell differentiation;GO:0033574|response to testosterone;GO:0035264|multicellular organism growth;GO:0042327|positive regulation of phosphorylation;GO:0043410|positive regulation of MAPK cascade;GO:0043568|positive regulation of insulin-like growth factor receptor signaling pathway;GO:0045597|positive regulation of cell differentiation;GO:0045720|negative regulation of integrin biosynthetic process;GO:0045726|positive regulation of integrin biosynthetic process;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0045945|positive regulation of transcription by RNA polymerase III;GO:0046661|male sex differentiation;GO:0048608|reproductive structure development;GO:0048638|regulation of developmental growth;GO:0048645|animal organ formation;GO:0048808|male genitalia morphogenesis;GO:0050680|negative regulation of epithelial cell proliferation;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0060406|positive regulation of penile erection;GO:0060520|activation of prostate induction by androgen receptor signaling pathway;GO:0060571|morphogenesis of an epithelial fold;GO:0060599|lateral sprouting involved in mammary gland duct morphogenesis;GO:0060685|regulation of prostatic bud formation;GO:0060736|prostate gland growth;GO:0060740|prostate gland epithelium morphogenesis;GO:0060742|epithelial cell differentiation involved in prostate gland development;GO:0060748|tertiary branching involved in mammary gland duct morphogenesis;GO:0060749|mammary gland alveolus development;GO:0060769|positive regulation of epithelial cell proliferation involved in prostate gland development;GO:0061458|reproductive system development;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0071383|cellular response to steroid hormone stimulus;GO:0071391|cellular response to estrogen stimulus;GO:0071394|cellular response to testosterone stimulus;GO:0072520|seminiferous tubule development;GO:1903076|regulation of protein localization to plasma membrane;GO:2001237|negative regulation of extrinsic apoptotic signaling pathway;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016607|nuclear speck;GO:0030424|axon;GO:0030425|dendrite;GO:0032991|protein-containing complex;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001091|RNA polymerase II basal transcription factor binding;GO:0001223|transcription coactivator binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003700|DNA-binding transcription factor activity;GO:0004879|nuclear receptor activity;GO:0005102|signaling receptor binding;GO:0005496|steroid binding;GO:0005497|androgen binding;GO:0005515|protein binding;GO:0008013|beta-catenin binding;GO:0008270|zinc ion binding;GO:0019899|enzyme binding;GO:0019904|protein domain specific binding;GO:0032553|ribonucleotide binding;GO:0043565|sequence-specific DNA binding;GO:0050681|androgen receptor binding;GO:0051117|ATPase binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;GO:0070974|POU domain binding;","K08557","AR, NR3C4; androgen receptor"]
["ENSRNOG00000010302",39,3.23803976,24,1.543930516,2.097270393,1.068512874,0.003631468,0.003186495,"up","yes","Rasl10b","protein_coding","chr10:68210275-68220376:+","gi|564373557|ref|XP_006247090.1|",1254,{"v":7e-169,"d":"7.00E-169"},"PREDICTED: ras-like protein family member 10B isoform X1 [Rattus norvegicus]","gi|672068619|ref|XM_006247028.2|",1518,0,"PREDICTED: Rattus norvegicus RAS-like, family 10, member B (Rasl10b), transcript variant X2, mRNA","Q5SSG5",404,{"v":5e-138,"d":"5.00E-138"},"Ras-like protein family member 10B",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0003050|regulation of systemic arterial blood pressure by atrial natriuretic peptide;GO:0090277|positive regulation of peptide hormone secretion;",".","GO:0003924|GTPase activity;GO:0005525|GTP binding;","K07851","RASL10B; Ras-like protein family member 10B"]
["ENSRNOG00000011705",39,3.23803976,24,1.543930516,2.097270393,1.068512874,0.003631468,0.003186495,"up","yes","Stmn2","protein_coding","chr2:93204692-93252011:-","gi|16758184|ref|NP_445892.1|",880,{"v":2e-111,"d":"2.00E-111"},"stathmin-2 [Rattus norvegicus]","gi|56799413|ref|NM_053440.2|",1802,0,"Rattus norvegicus stathmin 2 (Stmn2), mRNA","P21818",343,{"v":6e-113,"d":"6.00E-113"},"Stathmin-2",".",".",".",".","pfam00836","Stathmin","Stathmin family. The Stathmin family of proteins play an important role in the regulation of the microtubule cytoskeleton. They regulate microtubule dynamics by promoting depolymerization of microtubules and/or preventing polymerization of tubulin heterodimers.","GO:0007019|microtubule depolymerization;GO:0007026|negative regulation of microtubule depolymerization;GO:0010976|positive regulation of neuron projection development;GO:0010977|negative regulation of neuron projection development;GO:0031110|regulation of microtubule polymerization or depolymerization;GO:0031115|negative regulation of microtubule polymerization;GO:0031117|positive regulation of microtubule depolymerization;GO:0031175|neuron projection development;GO:1990090|cellular response to nerve growth factor stimulus;","GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005794|Golgi apparatus;GO:0016020|membrane;GO:0030027|lamellipodium;GO:0030426|growth cone;GO:0031982|vesicle;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0048471|perinuclear region of cytoplasm;","GO:0005515|protein binding;GO:0015631|tubulin binding;GO:0048306|calcium-dependent protein binding;",".","."]
["ENSRNOG00000059401",39,3.23803976,24,1.543930516,2.097270393,1.068512874,0.003631468,0.003186495,"up","yes","Ccdc40","protein_coding","chr10:104486748-104527243:+","gi|197927395|ref|NP_001128160.1|",6056,0,"coiled-coil domain-containing protein 40 [Rattus norvegicus]","gi|197927394|ref|NM_001134688.1|",5151,0,"Rattus norvegicus coiled-coil domain containing 40 (Ccdc40), mRNA","Q8BI79",1754,0,"Coiled-coil domain-containing protein 40",".",".",".",".","pfam08647","BRE1","BRE1 E3 ubiquitin ligase. BRE1 is an E3 ubiquitin ligase that has been shown to act as a transcriptional activator through direct activator interactions.","GO:0001947|heart looping;GO:0003341|cilium movement;GO:0003351|epithelial cilium movement;GO:0003356|regulation of cilium beat frequency;GO:0007368|determination of left/right symmetry;GO:0030317|flagellated sperm motility;GO:0030324|lung development;GO:0035082|axoneme assembly;GO:0035469|determination of pancreatic left/right asymmetry;GO:0036159|inner dynein arm assembly;GO:0044458|motile cilium assembly;GO:0060287|epithelial cilium movement involved in determination of left/right asymmetry;GO:0061512|protein localization to cilium;GO:0070286|axonemal dynein complex assembly;GO:0071907|determination of digestive tract left/right asymmetry;GO:0071910|determination of liver left/right asymmetry;","GO:0005576|extracellular region;GO:0005737|cytoplasm;GO:0005929|cilium;GO:0005930|axoneme;GO:0031514|motile cilium;",".","K23730","CCDC40; coiled-coil domain-containing protein 40"]
["ENSRNOG00000050658",21,1.743559871,9,0.578973944,3.011465179,1.590465578,3.706698E-3,3.24538E-3,"up","yes","Tacr2","protein_coding","chr20:30208907-30223446:+","gi|18158435|ref|NP_542946.1|",1999,0,"substance-K receptor [Rattus norvegicus]","gi|18158434|ref|NM_080768.1|",2979,0,"Rattus norvegicus tachykinin receptor 2 (Tacr2), mRNA","P16610",774,0,"Substance-K receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007217|tachykinin receptor signaling pathway;GO:0014057|positive regulation of acetylcholine secretion, neurotransmission;GO:0014827|intestine smooth muscle contraction;GO:0033685|negative regulation of luteinizing hormone secretion;GO:0035106|operant conditioning;GO:0043117|positive regulation of vascular permeability;GO:0043270|positive regulation of ion transport;GO:0051602|response to electrical stimulus;GO:0070459|prolactin secretion;GO:0070472|regulation of uterine smooth muscle contraction;GO:0070474|positive regulation of uterine smooth muscle contraction;GO:1902093|positive regulation of flagellated sperm motility;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0036126|sperm flagellum;GO:0061827|sperm head;GO:0097225|sperm midpiece;","GO:0004995|tachykinin receptor activity;GO:0016497|substance K receptor activity;","K04223","TACR2; tachykinin receptor 2"]
["ENSRNOG00000064621",26,2.158693174,13,0.836295696,2.581255868,1.368073156,0.003892262,0.003396224,"up","yes","ENSRNOG00000064621","pseudogene","chr10:36275559-36276041:-","gi|31560385|ref|NP_062621.2|",760,{"v":7e-101,"d":"7.00E-101"},"60S ribosomal protein L21 [Mus musculus]","gi|189163511|ref|NG_007893.1|",245,{"v":8e-124,"d":"8.00E-124"},"Rattus norvegicus ribosomal protein L21, pseudogene 1 (Rpl21-ps1) on chromosome 9","P49666",297,{"v":2e-102,"d":"2.00E-102"},"60S ribosomal protein L21","YBR191w",176,{"v":1e-55,"d":"1.00E-55"},"COG2139","pfam01157","Ribosomal_L21e","Ribosomal protein L21e.",".",".",".",".","."]
["ENSRNOG00000014629",42,3.487119742,27,1.736921831,2.007643453,1.005503077,0.004085215,0.003547642,"up","yes","Lmo1","protein_coding","chr1:163132339-163168522:-","gi|281341700|gb|EFB17284.1|",910,{"v":4e-118,"d":"4.00E-118"},"hypothetical protein PANDA_004271, partial [Ailuropoda melanoleuca]","gi|564330290|ref|XM_006229968.1|",1200,0,"PREDICTED: Rattus norvegicus LIM domain only 1 (Lmo1), transcript variant X1, mRNA","Q924W9",321,{"v":7e-107,"d":"7.00E-107"},"Rhombotin-1",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046013|regulation of T cell homeostatic proliferation;","GO:0005634|nucleus;","GO:0046872|metal ion binding;","K24098","LMO1_3; rhombotin-1/3"]
["ENSRNOG00000029197",27,2.241719834,14,0.900626135,2.489068158,1.315605736,0.004306768,0.003725872,"up","yes","Diablo","protein_coding","chr12:33055263-33070387:+","gi|564306161|ref|XP_002726674.2|",969,{"v":1e-121,"d":"1.00E-121"},"PREDICTED: diablo homolog, mitochondrial-like isoform X1 [Rattus norvegicus]","gi|56605641|ref|NM_001008292.1|",1290,0,"Rattus norvegicus diablo, IAP-binding mitochondrial protein (Diablo), mRNA","Q9JIQ3",339,{"v":5E-110,"d":"5.00E-110"},"Diablo homolog, mitochondrial",".",".",".",".","pfam09057","Smac_DIABLO","Second Mitochondria-derived Activator of Caspases. Second Mitochondria-derived Activator of Caspases promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway, and by opposing the inhibitory activity of inhibitor of apoptosis proteins (XIAP-BIR3). The protein assumes an elongated three-helix bundle structure, and forms a dimer in solution.","GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0008631|intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0008635|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c;GO:0043065|positive regulation of apoptotic process;GO:0051402|neuron apoptotic process;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;GO:0009898|cytoplasmic side of plasma membrane;GO:0035631|CD40 receptor complex;",".","K10522","DIABLO, SMAC; diablo"]
["ENSRNOG00000036910",27,2.241719834,14,0.900626135,2.489068158,1.315605736,0.004306768,0.003725872,"up","yes","ENSRNOG00000036910","protein_coding","chr4:182556345-182557508:-","gi|109472534|ref|XP_342750.3|",1747,0,"PREDICTED: beta-citrylglutamate synthase B [Rattus norvegicus]","gi|672018961|ref|XR_600910.1|",1164,0,"PREDICTED: Rattus norvegicus mKIAA1238 protein-like (LOC100362344), misc_RNA","Q80WS1",669,0,"Beta-citrylglutamate synthase B","MA1361",114,{"v":4e-28,"d":"4.00E-28"},"COG0189","pfam08443","RimK","RimK-like ATP-grasp domain. This ATP-grasp domain is found in the ribosomal S6 modification enzyme RimK.","GO:0006464|cellular protein modification process;","GO:0005737|cytoplasm;","GO:0005524|ATP binding;GO:0016879|ligase activity, forming carbon-nitrogen bonds;GO:0046872|metal ion binding;GO:0072590|N-acetyl-L-aspartate-L-glutamate ligase activity;",".","."]
["ENSRNOG00000000934",12,0.996319926,3,0.192991315,5.162511736,2.368073156,0.00430928,0.003727037,"up","yes","Piwil1","protein_coding","chr12:27949744-27970580:-","gi|148687585|gb|EDL19532.1|",4379,0,"piwi-like homolog 1 (Drosophila), isoform CRA_a, partial [Mus musculus]","gi|157819606|ref|NM_001108853.1|",4000,0,"Rattus norvegicus piwi-like RNA-mediated gene silencing 1 (Piwil1), mRNA","Q9JMB7",1681,0,"Piwi-like protein 1",".",".",".",".","pfam02171","Piwi","Piwi domain. This domain is found in the protein Piwi and its relatives. The function of this domain is the dsRNA guided hydrolysis of ssRNA. Determination of the crystal structure of Argonaute reveals that PIWI is an RNase H domain, and identifies Argonaute as Slicer, the enzyme that cleaves mRNA in the RNAi RISC complex. In addition, Mg+2 dependence and production of 3'-OH and 5' phosphate products are shared characteristics of RNaseH and RISC. The PIWI domain core has a tertiary structure belonging to the RNase H family of enzymes. RNase H fold proteins all have a five-stranded mixed beta-sheet surrounded by helices. By analogy to RNase H enzymes which cleave single-stranded RNA guided by the DNA strand in an RNA/DNA hybrid, the PIWI domain can be inferred to cleave single-stranded RNA, for example mRNA, guided by double stranded siRNA.","GO:0006417|regulation of translation;GO:0007283|spermatogenesis;GO:0007286|spermatid development;GO:0010529|negative regulation of transposition;GO:0031047|gene silencing by RNA;GO:0034587|piRNA metabolic process;GO:0035093|spermatogenesis, exchange of chromosomal proteins;GO:0090502|RNA phosphodiester bond hydrolysis, endonucleolytic;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0033391|chromatoid body;GO:0097433|dense body;","GO:0003727|single-stranded RNA binding;GO:0003729|mRNA binding;GO:0004521|endoribonuclease activity;GO:0019901|protein kinase binding;GO:0034584|piRNA binding;GO:0140262|mRNA cap binding complex binding;GO:1905538|polysome binding;","K02156","AUB, PIWI; aubergine"]
["ENSRNOG00000063598",12,0.996319926,3,0.192991315,5.162511736,2.368073156,0.00430928,0.003727037,"up","yes","ENSRNOG00000063598","lncRNA","chr1:66769938-66775913:-",".",".",".",".","gi|354797582|gb|JN962083.1|",327,{"v":1E-168,"d":"1.00E-168"},"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Zfp773:tm1a(EUCOMM)Hmgu; transgenic",".",".",".",".",".",".",".",".","pfam15030","DUF4527","Protein of unknown function (DUF4527). This family of proteins is functionally uncharacterized. This family of proteins is found in vertebrates.",".",".",".",".","."]
["ENSRNOG00000066754",22,1.826586532,10,0.643304382,2.839381455,1.50557668,0.00432375,0.00373717,"up","yes","ENSRNOG00000066754","lncRNA","chr3:141362034-141376460:-",".",".",".",".","gi|86439996|gb|AC129342.5|",1367,0,"Rattus norvegicus BAC CH230-229B21 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam10101","DUF2339","Predicted membrane protein (DUF2339). This domain, found in various hypothetical bacterial proteins, has no known function.",".",".",".",".","."]
["ENSRNOG00000031782",18,1.494479889,7,0.450313067,3.318757544,1.730643236,0.004324503,0.00373717,"up","yes","Col6a4","protein_coding","chr8:106617050-106733263:-","gi|161788949|dbj|BAF95091.1|",8833,0,"double von Willebrand factor A domains [Mus musculus]","gi|403225004|ref|NM_001271182.1|",4350,0,"Rattus norvegicus collagen, type VI, alpha 4 (Col6a4), mRNA","A2AX52",3401,0,"Collagen alpha-4(VI) chain",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0030198|extracellular matrix organization;",".",".","K06238","COL6A; collagen type VI alpha"]
["ENSRNOG00000058372",18,1.494479889,7,0.450313067,3.318757544,1.730643236,0.004324503,0.00373717,"up","yes","Ac1576","protein_coding","chr10:68914830-68930985:-","gi|567316103|ref|NP_001274553.1|",1970,0,"uncharacterized protein LOC102552783 [Rattus norvegicus]","gi|567316102|ref|NM_001287624.1|",1143,0,"Rattus norvegicus uncharacterized LOC102552783 (Ac1576), mRNA","P12894",145,{"v":3e-36,"d":"3.00E-36"},"Intracisternal A-particle Pol-related polyprotein (Fragment)",".",".",".",".","pfam00552","IN_DBD_C","Integrase DNA binding domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain. The central domain is the catalytic domain pfam00665. This domain is the carboxyl terminal domain that is a non-specific DNA binding domain.",".",".",".",".","."]
["ENSRNOG00000069162",18,1.494479889,7,0.450313067,3.318757544,1.730643236,0.004324503,0.00373717,"up","yes","ENSRNOG00000069162","lncRNA","chr15:9909331-9940191:-","gi|149051113|gb|EDM03286.1|",163,{"v":3E-10,"d":"3.00E-10"},"rCG62332, isoform CRA_a [Rattus norvegicus]","gi|78486728|gb|AC158537.2|",396,0,"Mus musculus BAC clone RP23-2H7 from chromosome 14, complete sequence",".",".",".",".",".",".",".",".","pfam10277","Frag1","Frag1/DRAM/Sfk1 family. This family includes Frag1, DRAM and Sfk1 proteins. Frag1 (FGF receptor activating protein 1) is a protein that is conserved from fungi to humans. There are four potential iso-prenylation sites throughout the peptide, viz CILW, CIIW and CIGL. Frag1 is a membrane-spanning protein that is ubiquitously expressed in adult tissues suggesting an important cellular function. Dram is a family of proteins conserved from nematodes to humans with six hydrophobic transmembrane regions and an Endoplasmic Reticulum signal peptide. It is a lysosomal protein that induces macro-autophagy as an effector of p53-mediated death, where p53 is the tumor-suppressor gene that is frequently mutated in cancer. Expression of Dram is stress-induced. This region is also part of a family of small plasma membrane proteins, referred to as Sfk1, that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, thus allowing proper localisation of Stt4p to the actin cytoskeleton.",".",".",".",".","."]
["ENSRNOG00000012307",34,2.822906458,20,1.286608764,2.194067488,1.133607903,0.004388353,0.003788523,"up","yes","Mybpc3","protein_coding","chr3:77095252-77113405:+","gi|564341755|ref|XP_006234565.1|",6507,0,"PREDICTED: myosin-binding protein C, cardiac-type isoform X1 [Rattus norvegicus]","gi|564341756|ref|XM_006234504.1|",4165,0,"PREDICTED: Rattus norvegicus myosin binding protein C, cardiac (Mybpc3), transcript variant X1, mRNA","P56741",2498,0,"Myosin-binding protein C, cardiac-type",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0002027|regulation of heart rate;GO:0003007|heart morphogenesis;GO:0006936|muscle contraction;GO:0006942|regulation of striated muscle contraction;GO:0007155|cell adhesion;GO:0008016|regulation of heart contraction;GO:0031034|myosin filament assembly;GO:0045214|sarcomere organization;GO:0055010|ventricular cardiac muscle tissue morphogenesis;GO:0060048|cardiac muscle contraction;","GO:0005863|striated muscle myosin thick filament;GO:0030016|myofibril;GO:0030017|sarcomere;GO:0031672|A band;GO:0097512|cardiac myofibril;","GO:0003674|molecular_function;GO:0003779|actin binding;GO:0008307|structural constituent of muscle;GO:0017022|myosin binding;GO:0032036|myosin heavy chain binding;GO:0042802|identical protein binding;GO:0046872|metal ion binding;","K12568","MYBPC3; myosin-binding protein C, cardiac-type"]
["ENSRNOG00000000905",15,1.245399908,5,0.321652191,3.871883802,1.953035657,0.004677439,0.004016657,"up","yes","Tex26","protein_coding","chr12:5573691-5610498:-","gi|564378063|ref|XP_006248873.1|",1583,0,"PREDICTED: testis-expressed sequence 26 protein isoform X1 [Rattus norvegicus]","gi|672072065|ref|XM_006248811.2|",1506,0,"PREDICTED: Rattus norvegicus testis expressed 26 (Tex26), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam15304","AKAP2_C","A-kinase anchor protein 2 C-terminus. This family includes the C-terminus of A-kinase anchor protein 2 (AKAP2). It includes the site where the regulatory subunits (RII) of protein kinase AII binds.",".","GO:0005737|cytoplasm;",".",".","."]
["ENSRNOG00000016349",15,1.245399908,5,0.321652191,3.871883802,1.953035657,0.004677439,0.004016657,"up","yes","Gnmt","protein_coding","chr9:14254675-14258434:+","gi|8567354|ref|NP_058780.1|",1258,{"v":8e-169,"d":"8.00E-169"},"glycine N-methyltransferase [Rattus norvegicus]","gi|56296|emb|X07833.1|",874,0,"Rat glycine methyltransferase gene (EC 2.1.1.20)","P13255",489,{"v":3e-170,"d":"3.00E-170"},"Glycine N-methyltransferase","BS_yqeM",59.3,4e-09,"COG0500","pfam12847","Methyltransf_18","Methyltransferase domain. Protein in this family function as methyltransferases.","GO:0005977|glycogen metabolic process;GO:0006111|regulation of gluconeogenesis;GO:0006544|glycine metabolic process;GO:0006555|methionine metabolic process;GO:0006730|one-carbon metabolic process;GO:0032259|methylation;GO:0046498|S-adenosylhomocysteine metabolic process;GO:0046500|S-adenosylmethionine metabolic process;GO:0046655|folic acid metabolic process;GO:0051289|protein homotetramerization;GO:1901052|sarcosine metabolic process;","GO:0005634|nucleus;GO:0005829|cytosol;GO:0034708|methyltransferase complex;","GO:0005542|folic acid binding;GO:0008757|S-adenosylmethionine-dependent methyltransferase activity;GO:0016594|glycine binding;GO:0017174|glycine N-methyltransferase activity;GO:0042802|identical protein binding;GO:0098603|selenol Se-methyltransferase activity;GO:1904047|S-adenosyl-L-methionine binding;","K00552","GNMT; glycine N-methyltransferase [EC:2.1.1.20]"]
["ENSRNOG00000019770",15,1.245399908,5,0.321652191,3.871883802,1.953035657,0.004677439,0.004016657,"up","yes","Bnc1","protein_coding","chr1:135917687-135943333:-","gi|157821307|ref|NP_001102386.1|",4685,0,"zinc finger protein basonuclin-1 [Rattus norvegicus]","gi|157821306|ref|NM_001108916.1|",4722,0,"Rattus norvegicus basonuclin 1 (Bnc1), mRNA","O35914",1702,0,"Zinc finger protein basonuclin-1",".",".",".",".","pfam13894","zf-C2H2_4","C2H2-type zinc finger. This family contains a number of divergent C2H2 type zinc fingers.","GO:0006355|regulation of transcription, DNA-templated;GO:0006356|regulation of transcription by RNA polymerase I;GO:0006357|regulation of transcription by RNA polymerase II;GO:0042060|wound healing;GO:0045943|positive regulation of transcription by RNA polymerase I;GO:0050679|positive regulation of epithelial cell proliferation;GO:0051276|chromosome organization;GO:1900195|positive regulation of oocyte maturation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0043231|intracellular membrane-bounded organelle;","GO:0000182|rDNA binding;GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0001216|bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding;","K24146","BNC; zinc finger protein basonuclin"]
["ENSRNOG00000038957",15,1.245399908,5,0.321652191,3.871883802,1.953035657,0.004677439,0.004016657,"up","yes","RGD1305184","protein_coding","chr18:53851449-53852696:+","gi|293354966|ref|XP_225905.4|",2123,0,"PREDICTED: interferon-inducible GTPase 1 [Rattus norvegicus]","gi|672030730|ref|XM_006222579.2|",1248,0,"PREDICTED: Rattus norvegicus similar to CDNA sequence BC023105 (RGD1305184), mRNA","Q9QZ85",426,{"v":3e-145,"d":"3.00E-145"},"Interferon-inducible GTPase 1",".",".",".",".","pfam05049","IIGP","Interferon-inducible GTPase (IIGP). Interferon-inducible GTPase (IIGP) is thought to play a role in in intracellular defence. IIGP is predominantly associated with the Golgi apparatus and also localizes to the endoplasmic reticulum and exerts a distinct role in IFN-induced intracellular membrane trafficking or processing.","GO:0006952|defense response;GO:0035458|cellular response to interferon-beta;","GO:0005789|endoplasmic reticulum membrane;","GO:0003924|GTPase activity;GO:0005525|GTP binding;",".","."]
["ENSRNOG00000070111",15,1.245399908,5,0.321652191,3.871883802,1.953035657,0.004677439,0.004016657,"up","yes","Apol2","protein_coding","chr7:109331392-109338558:-","gi|392341617|ref|XP_001075828.3|",1457,0,"PREDICTED: apolipoprotein L2 isoform X2 [Rattus norvegicus]","gi|672060336|ref|XM_006241955.2|",2016,0,"PREDICTED: Rattus norvegicus apolipoprotein L3-like (LOC100911804), transcript variant X6, mRNA","Q9BQE5",167,{"v":2e-43,"d":"2.00E-43"},"Apolipoprotein L2",".",".",".",".","pfam05461","ApoL","Apolipoprotein L. Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.",".",".",".",".","."]
["ENSRNOG00000062389",23,1.909613192,11,0.70763482,2.69858568,1.432203494,0.004939102,0.004221414,"up","yes","ENSRNOG00000062389","lncRNA","chr19:18779825-18781459:-",".",".",".",".","gi|21844686|gb|AC112258.4|",207,{"v":3E-102,"d":"3.00E-102"},"Mus musculus BAC clone RP23-169M10 from 8, complete sequence",".",".",".",".",".",".",".",".","pfam13388","DUF4106","Protein of unknown function (DUF4106). This family of proteins are found in large numbers in the Trichomonas vaginalis proteome. The function of this protein is unknown.",".",".",".",".","."]
["ENSRNOG00000000838",7,0.581186624,0,0.032165219,18.06879108,4.175428078,4.945769E-3,0.004221414,"up","yes","Lta","protein_coding","chr20:3618853-3620859:+","gi|18158437|ref|NP_542947.1|",939,{"v":1e-122,"d":"1.00E-122"},"lymphotoxin-alpha precursor [Rattus norvegicus]","gi|260314477|ref|NM_080769.2|",1341,0,"Rattus norvegicus lymphotoxin alpha (Lta), mRNA","Q06332",366,{"v":4e-124,"d":"4.00E-124"},"Lymphotoxin-alpha",".",".",".",".","pfam00229","TNF","TNF(tumor Necrosis Factor) family.","GO:0001666|response to hypoxia;GO:0002876|positive regulation of chronic inflammatory response to antigenic stimulus;GO:0002925|positive regulation of humoral immune response mediated by circulating immunoglobulin;GO:0006959|humoral immune response;GO:0007165|signal transduction;GO:0007584|response to nutrient;GO:0009410|response to xenobiotic stimulus;GO:0032496|response to lipopolysaccharide;GO:0032729|positive regulation of interferon-gamma production;GO:0043065|positive regulation of apoptotic process;GO:0048147|negative regulation of fibroblast proliferation;GO:0048535|lymph node development;GO:0050830|defense response to Gram-positive bacterium;GO:0060252|positive regulation of glial cell proliferation;","GO:0005615|extracellular space;GO:0016020|membrane;","GO:0003674|molecular_function;GO:0005125|cytokine activity;GO:0005164|tumor necrosis factor receptor binding;","K05468","LTA, TNFB; lymphotoxin alpha (TNF superfamily, member 1)"]
["ENSRNOG00000004852",7,0.581186624,0,0.032165219,18.06879108,4.175428078,4.945769E-3,0.004221414,"up","yes","Sel1l2","protein_coding","chr3:127586976-127713817:-","gi|62078831|ref|NP_001014071.1|",3202,0,"protein sel-1 homolog 2 precursor [Rattus norvegicus]","gi|62078830|ref|NM_001014049.1|",2209,0,"Rattus norvegicus SEL1L2 ERAD E3 ligase adaptor subunit (Sel1l2), mRNA","Q5XI05",1238,0,"Protein sel-1 homolog 2","SPAC1B3.10c",101,{"v":2e-21,"d":"2.00E-21"},"COG0790","pfam08238","Sel1","Sel1 repeat. This short repeat is found in the Sel1 protein. It is related to TPR repeats.","GO:0016567|protein ubiquitination;GO:0030433|ubiquitin-dependent ERAD pathway;","GO:0000839|Hrd1p ubiquitin ligase ERAD-L complex;GO:0016021|integral component of membrane;","GO:0004842|ubiquitin-protein transferase activity;","K14026","SEL1, SEL1L; SEL1 protein"]
["ENSRNOG00000018528",7,0.581186624,0,0.032165219,18.06879108,4.175428078,4.945769E-3,0.004221414,"up","yes","Nrl","protein_coding","chr15:29008104-29009832:-","gi|157822971|ref|NP_001099506.1|",957,{"v":4e-128,"d":"4.00E-128"},"neural retina-specific leucine zipper protein [Rattus norvegicus]","gi|672078022|ref|XM_006251937.2|",717,0,"PREDICTED: Rattus norvegicus neural retina leucine zipper (Nrl), transcript variant X3, mRNA","P54846",347,{"v":3e-119,"d":"3.00E-119"},"Neural retina-specific leucine zipper protein",".",".",".",".","pfam03131","bZIP_Maf","bZIP Maf transcription factor. Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerization and DNA binding property. Thus, this family is probably related to pfam00170. This family also includes the DNA_binding domain of Skn-1, this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer.","GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0010628|positive regulation of gene expression;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046548|retinal rod cell development;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0043522|leucine zipper domain binding;GO:1990837|sequence-specific double-stranded DNA binding;GO:1990841|promoter-specific chromatin binding;","K09038","NRL; neural retina-specific leucine zipper protein"]
["ENSRNOG00000020077",7,0.581186624,0,0.032165219,18.06879108,4.175428078,4.945769E-3,0.004221414,"up","yes","Fam170b","protein_coding","chr16:8101914-8104705:+","gi|564318559|ref|XP_006222176.1|",1229,{"v":4e-162,"d":"4.00E-162"},"PREDICTED: putative protein FAM170B [Rattus norvegicus]","gi|672029060|ref|XM_006222114.2|",1667,0,"PREDICTED: Rattus norvegicus family with sequence similarity 170, member B (Fam170b), transcript variant X1, mRNA","E9PXT9",437,{"v":1e-147,"d":"1.00E-147"},"Protein FAM170B",".",".",".",".","pfam12756","zf-C2H2_2","C2H2 type zinc-finger (2 copies). This family contains two copies of a C2H2-like zinc finger domain.","GO:0009566|fertilization;GO:0080154|regulation of fertilization;GO:2000344|positive regulation of acrosome reaction;","GO:0001669|acrosomal vesicle;GO:0002081|outer acrosomal membrane;",".",".","."]
["ENSRNOG00000020420",7,0.581186624,0,0.032165219,18.06879108,4.175428078,4.945769E-3,0.004221414,"up","yes","Pklr","protein_coding","chr2:174543039-174551870:+","gi|185134818|ref|NP_036756.3|",2851,0,"pyruvate kinase PKLR [Rattus norvegicus]","gi|185134817|ref|NM_012624.3|",2902,0,"Rattus norvegicus pyruvate kinase, liver and RBC (Pklr), mRNA","P12928",1102,0,"Pyruvate kinase PKLR","SPAC4H3.10c",518,{"v":3e-170,"d":"3.00E-170"},"COG0469","pfam00224","PK","Pyruvate kinase, barrel domain. This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.","GO:0001666|response to hypoxia;GO:0005975|carbohydrate metabolic process;GO:0006096|glycolytic process;GO:0006754|ATP biosynthetic process;GO:0007584|response to nutrient;GO:0009408|response to heat;GO:0009749|response to glucose;GO:0010038|response to metal ion;GO:0010226|response to lithium ion;GO:0032869|cellular response to insulin stimulus;GO:0033198|response to ATP;GO:0042866|pyruvate biosynthetic process;GO:0051591|response to cAMP;GO:0051707|response to other organism;GO:0071872|cellular response to epinephrine stimulus;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0000287|magnesium ion binding;GO:0004743|pyruvate kinase activity;GO:0005524|ATP binding;GO:0016301|kinase activity;GO:0030955|potassium ion binding;","K12406","PKLR; pyruvate kinase isozymes R/L [EC:2.7.1.40]"]
["ENSRNOG00000054013",7,0.581186624,0,0.032165219,18.06879108,4.175428078,4.945769E-3,0.004221414,"up","yes","Clec4g","protein_coding","chr12:1780371-1784985:-","gi|672072155|ref|XP_008767238.1|",1319,{"v":2E-179,"d":"2.00E-179"},"PREDICTED: LOW QUALITY PROTEIN: C-type lectin domain family 4 member G isoform X2 [Rattus norvegicus]","gi|672072154|ref|XM_008769016.1|",1134,0,"PREDICTED: Rattus norvegicus C-type lectin domain family 4, member G (Clec4g), transcript variant X2, mRNA","Q8BNX1",483,{"v":2E-169,"d":"2.00E-169"},"C-type lectin domain family 4 member G",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0002710|negative regulation of T cell mediated immunity;GO:0042130|negative regulation of T cell proliferation;GO:0046718|viral entry into host cell;GO:1903902|positive regulation of viral life cycle;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;","GO:0001618|virus receptor activity;GO:0005537|mannose binding;GO:0030247|polysaccharide binding;GO:0070061|fructose binding;GO:0097367|carbohydrate derivative binding;","K10061","CLEC4G; C-type lectin superfamily 4 member G"]
["ENSRNOG00000062843",7,0.581186624,0,0.032165219,18.06879108,4.175428078,4.945769E-3,0.004221414,"up","yes","ENSRNOG00000062843","lncRNA","chr20:9330630-9334059:-",".",".",".",".","gi|62868185|gb|AC154652.2|",118,{"v":8e-53,"d":"8.00E-53"},"Mus musculus BAC clone RP24-261L18 from chromosome 17, complete sequence",".",".",".",".",".",".",".",".","pfam07672","MFS_Mycoplasma","Mycoplasma MFS transporter. These proteins share some similarity with members of the Major Facilitator Superfamily (MFS).",".",".",".",".","."]
["ENSRNOG00000068051",7,0.581186624,0,0.032165219,18.06879108,4.175428078,4.945769E-3,0.004221414,"up","yes","ENSRNOG00000068051","lncRNA","chr1:206619457-206621850:+",".",".",".",".","gi|42517254|gb|AC134437.3|",586,0,"Mus musculus BAC clone RP24-450H12 from chromosome 19, complete sequence",".",".",".",".",".",".",".",".","pfam15483","DUF4641","Domain of unknown function (DUF4641). This family of proteins is found in eukaryotes. Proteins in this family are typically between 201 and 519 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000068609",7,0.581186624,0,0.032165219,18.06879108,4.175428078,4.945769E-3,0.004221414,"up","yes","ENSRNOG00000068609","protein_coding","chr1:98119267-98135359:-","gi|74195263|dbj|BAE28359.1|",249,{"v":3E-24,"d":"3.00E-24"},"unnamed protein product [Mus musculus]","gi|33325617|gb|AF518239.1|",154,{"v":1E-73,"d":"1.00E-73"},"Rattus norvegicus MRGB1 G protein-coupled receptor (Mrgb1) gene, complete cds","Q3UG50",100,{"v":9e-26,"d":"9.00E-26"},"Mas-related G-protein coupled receptor member X2",".",".",".",".","pfam03998","Utp11","Utp11 protein. This protein is found to be part of a large ribonucleoprotein complex containing the U3 snoRNA. Depletion of the Utp proteins impedes production of the 18S rRNA, indicating that they are part of the active pre-rRNA processing complex. This large RNP complex has been termed the small subunit (SSU) processome.",".",".",".",".","."]
["ENSRNOG00000070540",7,0.581186624,0,0.032165219,18.06879108,4.175428078,4.945769E-3,0.004221414,"up","yes","ENSRNOG00000070540","protein_coding","chr11:81944458-81946438:+","gi|204870|gb|AAA41420.1|",555,{"v":1e-64,"d":"1.00E-64"},"Ig lambda-chain C2-region, partial [Rattus norvegicus]","gi|204877|gb|M21780.1|RATIGLCH",1102,0,"Rat Ig germline lambda-chain C-region gene (C-lambda-2), 3' end","P20767",216,{"v":3E-65,"d":"3.00E-65"},"Ig lambda-2 chain C region",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.",".",".",".",".","."]
["ENSRNOG00000071008",7,0.581186624,0,0.032165219,18.06879108,4.175428078,4.945769E-3,0.004221414,"up","yes","ENSRNOG00000071008","protein_coding","chr18:1900890-1902758:-","gi|564375465|ref|XP_213532.4|",478,{"v":1E-56,"d":"1.00E-56"},"PREDICTED: UBA-like domain-containing protein 2 isoform X2 [Rattus norvegicus]","gi|672070066|ref|XM_213532.7|",295,{"v":1e-151,"d":"1.00E-151"},"PREDICTED: Rattus norvegicus UBA-like domain containing 2 (Ubald2), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam15449","Retinal","Retinal protein. This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.",".",".",".",".","."]
["ENSRNOG00000065112",29,2.407773155,16,1.029287011,2.33926313,1.226054151,5.104758E-3,0.004346252,"up","yes","ENSRNOG00000065112","protein_coding","chr1:167210874-167213149:+","gi|281306796|ref|NP_001162610.1|",3415,0,"cytoskeleton-associated protein 2 [Rattus norvegicus]","gi|281306795|ref|NM_001169139.1|",2203,0,"Rattus norvegicus cytoskeleton associated protein 2 (Ckap2), mRNA","Q3V1H1",1027,0,"Cytoskeleton-associated protein 2",".",".",".",".","pfam15297","CKAP2_C","Cytoskeleton-associated protein 2 C-terminus. This family includes the C-terminus of CKAP2 and CKAP2L. CKAP2 is a microtubule associated protein which stabilizes microtubules.",".",".",".",".","."]
["ENSRNOG00000010507",10,0.830266605,2,0.128660876,6.45313967,2.690001251,0.005117971,0.004353573,"up","yes","Mmp7","protein_coding","chr8:4848186-4855902:+","gi|6981214|ref|NP_036996.1|",1414,0,"matrilysin precursor [Rattus norvegicus]","gi|166091437|ref|NM_012864.2|",804,0,"Rattus norvegicus matrix metallopeptidase 7 (Mmp7), mRNA","P50280",549,0,"Matrilysin",".",".",".",".","pfam00413","Peptidase_M10","Matrixin. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.","GO:0002779|antibacterial peptide secretion;GO:0002780|antibacterial peptide biosynthetic process;GO:0006508|proteolysis;GO:0006509|membrane protein ectodomain proteolysis;GO:0007568|aging;GO:0009410|response to xenobiotic stimulus;GO:0030198|extracellular matrix organization;GO:0030335|positive regulation of cell migration;GO:0030574|collagen catabolic process;GO:0031293|membrane protein intracellular domain proteolysis;GO:0031667|response to nutrient levels;GO:0042127|regulation of cell proliferation;GO:0042742|defense response to bacterium;GO:0044849|estrous cycle;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:0060135|maternal process involved in female pregnancy;GO:0071260|cellular response to mechanical stimulus;","GO:0005615|extracellular space;GO:0009986|cell surface;GO:0031012|extracellular matrix;","GO:0004175|endopeptidase activity;GO:0004222|metalloendopeptidase activity;GO:0008201|heparin binding;GO:0008233|peptidase activity;GO:0008237|metallopeptidase activity;GO:0008270|zinc ion binding;","K01397","MMP7; matrix metalloproteinase-7 (matrilysin, uterine) [EC:3.4.24.23]"]
["ENSRNOG00000020514",10,0.830266605,2,0.128660876,6.45313967,2.690001251,0.005117971,0.004353573,"up","yes","Sox6","protein_coding","chr1:169729194-170277386:-","gi|564330572|ref|XP_006230149.1|",3766,0,"PREDICTED: transcription factor SOX-6 isoform X1 [Rattus norvegicus]","gi|672037787|ref|XM_006230089.2|",2689,0,"PREDICTED: Rattus norvegicus SRY (sex determining region Y)-box 6 (Sox6), transcript variant X4, mRNA","P40645",1435,0,"Transcription factor SOX-6",".",".",".",".","pfam00505","HMG_box","HMG (high mobility group) box.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0000902|cell morphogenesis;GO:0001502|cartilage condensation;GO:0001701|in utero embryonic development;GO:0002062|chondrocyte differentiation;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007417|central nervous system development;GO:0007420|brain development;GO:0009791|post-embryonic development;GO:0010468|regulation of gene expression;GO:0016458|gene silencing;GO:0021529|spinal cord oligodendrocyte cell differentiation;GO:0021778|oligodendrocyte cell fate specification;GO:0030097|hemopoiesis;GO:0030218|erythrocyte differentiation;GO:0032332|positive regulation of chondrocyte differentiation;GO:0042692|muscle cell differentiation;GO:0045165|cell fate commitment;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048708|astrocyte differentiation;GO:0048709|oligodendrocyte differentiation;GO:0048821|erythrocyte development;GO:0051216|cartilage development;GO:0055007|cardiac muscle cell differentiation;GO:0061036|positive regulation of cartilage development;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:2000726|negative regulation of cardiac muscle cell differentiation;GO:2000741|positive regulation of mesenchymal stem cell differentiation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987|proximal promoter sequence-specific DNA binding;GO:0001217|bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0042803|protein homodimerization activity;GO:0043565|sequence-specific DNA binding;","K09269","SOX5_6_13; transcription factor SOX5/6/13 (SOX group D)"]
["ENSRNOG00000063601",10,0.830266605,2,0.128660876,6.45313967,2.690001251,0.005117971,0.004353573,"up","yes","Tex33","protein_coding","chr7:109928173-109947072:-","gi|112983852|ref|NP_001037754.1|",1416,0,"testis-expressed sequence 33 protein [Rattus norvegicus]","gi|112983851|ref|NM_001044289.1|",905,0,"Rattus norvegicus testis expressed 33 (Tex33), mRNA",".",".",".",".",".",".",".",".","pfam15400","TEX33","Testis-expressed sequence 33 protein family. This family of proteins is found in eukaryotes. Proteins in this family are typically between 147 and 280 amino acids in length. There are two conserved sequence motifs: NIRH and SYT. The function is not known.",".",".",".",".","."]
["ENSRNOG00000065742",10,0.830266605,2,0.128660876,6.45313967,2.690001251,0.005117971,0.004353573,"up","yes","ENSRNOG00000065742","protein_coding","chr2:231461798-231474541:-","gi|564301078|ref|XP_003753729.2|",2514,0,"PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC685116 isoform X1 [Rattus norvegicus]","gi|672016388|ref|XM_003753681.3|",1163,0,"PREDICTED: Rattus norvegicus similar to guanylate binding protein family, member 6 (LOC685116), transcript variant X1, mRNA","Q61107",702,0,"Guanylate-binding protein 4",".",".",".",".","pfam02841","GBP_C","Guanylate-binding protein, C-terminal domain. Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.",".",".",".",".","."]
["ENSRNOG00000068191",10,0.830266605,2,0.128660876,6.45313967,2.690001251,0.005117971,0.004353573,"up","yes","ENSRNOG00000068191","lncRNA","chr19:47392403-47400874:-",".",".",".",".","gi|25136968|emb|AL691505.12|",115,{"v":1E-51,"d":"1.00E-51"},"Mouse DNA sequence from clone RP23-82B19 on chromosome 10, complete sequence",".",".",".",".",".",".",".",".","pfam13413","HTH_25","Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.",".",".",".",".","."]
["ENSRNOG00000000878",19,1.57750655,8,0.514643505,3.065241343,1.61600067,0.005232126,4.442863E-3,"up","yes","Slc44a4","protein_coding","chr20:3903099-3919215:-","gi|47087113|ref|NP_997706.1|",3040,0,"choline transporter-like protein 4 [Rattus norvegicus]","gi|47087112|ref|NM_212541.1|",2254,0,"Rattus norvegicus solute carrier family 44, member 4 (Slc44a4), mRNA","Q6MG71",1175,0,"Choline transporter-like protein 4",".",".",".",".","pfam04515","Choline_transpo","Plasma-membrane choline transporter. This family represents a high-affinity plasma-membrane choline transporter in C.elegans which is thought to be rate-limiting for ACh synthesis in cholinergic nerve terminals.","GO:0008292|acetylcholine biosynthetic process;GO:0015871|choline transport;GO:0030307|positive regulation of cell growth;GO:0030974|thiamine pyrophosphate transmembrane transport;GO:0032475|otolith formation;GO:0035675|neuromast hair cell development;GO:0055085|transmembrane transport;GO:0061526|acetylcholine secretion;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;","GO:0015220|choline transmembrane transporter activity;GO:0022857|transmembrane transporter activity;GO:0090422|thiamine pyrophosphate transmembrane transporter activity;","K15377","SLC44A2_4_5; solute carrier family 44 (choline transporter-like protein), member 2/4/5"]
["ENSRNOG00000039759",19,1.57750655,8,0.514643505,3.065241343,1.61600067,0.005232126,4.442863E-3,"up","yes","ENSRNOG00000039759","protein_coding","chrX:9104565-9148601:-","gi|67972437|ref|NP_001020096.1|",1970,0,"probable G-protein coupled receptor 34 [Rattus norvegicus]","gi|672086955|ref|XM_006256676.2|",1977,0,"PREDICTED: Rattus norvegicus G protein-coupled receptor 34 (Gpr34), transcript variant X2, mRNA","Q9R1K6",728,0,"Probable G-protein coupled receptor 34",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0035589|G protein-coupled purinergic nucleotide receptor signaling pathway;","GO:0016021|integral component of membrane;","GO:0045028|G protein-coupled purinergic nucleotide receptor activity;","K08383","GPR34; G protein-coupled receptor 34"]
["ENSRNOG00000064755",19,1.57750655,8,0.514643505,3.065241343,1.61600067,0.005232126,4.442863E-3,"up","yes","ENSRNOG00000064755","protein_coding","chr17:42798180-42799117:-","gi|672030157|ref|XP_001061048.2|",744,{"v":3e-95,"d":"3.00E-95"},"PREDICTED: histone H3.1 [Rattus norvegicus]","gi|672030156|ref|XM_001061048.4|",618,0,"PREDICTED: Rattus norvegicus similar to histone 1, H2ai (LOC682330), mRNA","Q6LED0",275,{"v":2E-91,"d":"2.00E-91"},"Histone H3.1",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.",".",".",".",".","."]
["ENSRNOG00000020720",38,3.1550131,24,1.543930516,2.043494229,1.031038169,5.29782E-3,0.004491489,"up","yes","Fbxw12","protein_coding","chr8:109786815-109801813:-","gi|672023340|ref|XP_001075538.3|",2307,0,"PREDICTED: F-box/WD repeat-containing protein 12 [Rattus norvegicus]","gi|672023339|ref|XM_001075538.3|",1291,0,"PREDICTED: Rattus norvegicus F-box and WD repeat domain containing 12 (Fbxw12), mRNA","L7N1X6",580,0,"F-box/WD repeat-containing protein 15",".",".",".",".","pfam12937","F-box-like","F-box-like. This is an F-box-like family.",".",".",".","K10267","FBXW12S; F-box and WD-40 domain protein 12/13/14/15/16/17/19"]
["ENSRNOG00000000713",8,0.664213284,1,0.064330438,10.32502347,3.368073156,0.005310419,4.498592E-3,"up","yes","AABR07033045.1","protein_coding","chr11:3453464-3454395:-","gi|795615483|ref|XP_011729715.1|",1265,{"v":2E-171,"d":"2.00E-171"},"PREDICTED: septin-7 isoform X1 [Macaca nemestrina]","gi|329299063|ref|NM_009859.4|",732,0,"Mus musculus septin 7 (Sept7), transcript variant 1, mRNA","O55131",451,{"v":1E-156,"d":"1.00E-156"},"Septin-7","SPAC4F10.11",191,{"v":4e-59,"d":"4.00E-59"},"COG5019","pfam00735","Septin","Septin. Members of this family include CDC3, CDC10, CDC11 and CDC12/Septin. Members of this family bind GTP. As regards the septins, these are polypeptides of 30-65kDa with three characteristic GTPase motifs (G-1, G-3 and G-4) that are similar to those of the Ras family. The G-4 motif is strictly conserved with a unique septin consensus of AKAD. Most septins are thought to have at least one coiled-coil region, which in some cases is necessary for intermolecular interactions that allow septins to polymerize to form rod-shaped complexes. In turn, these are arranged into tandem arrays to form filaments. They are multifunctional proteins, with roles in cytokinesis, sporulation, germ cell development, exocytosis and apoptosis.",".",".",".",".","."]
["ENSRNOG00000013959",8,0.664213284,1,0.064330438,10.32502347,3.368073156,0.005310419,4.498592E-3,"up","yes","Skor1","protein_coding","chr8:63599165-63607756:-","gi|672022912|ref|XP_006226487.2|",3536,0,"PREDICTED: SKI family transcriptional corepressor 1 isoform X2 [Rattus norvegicus]","gi|672022911|ref|XM_006226425.2|",3574,0,"PREDICTED: Rattus norvegicus SKI family transcriptional corepressor 1 (Skor1), transcript variant X2, mRNA","P84551",1366,0,"SKI family transcriptional corepressor 1",".",".",".",".","pfam02437","Ski_Sno","SKI/SNO/DAC family. This family contains a presumed domain that is about 100 amino acids long. All members of this family contain a conserved CLPQ motif. The c-ski proto-oncogene has been shown to influence proliferation, morphological transformation and myogenic differentiation. Sno, a Ski proto-oncogene homologue, is expressed in two isoforms and plays a role in the response to proliferation stimuli. Dachshund also contains this domain. It is involved in various aspects of development.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0008150|biological_process;GO:0030514|negative regulation of BMP signaling pathway;GO:0045892|negative regulation of transcription, DNA-templated;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005667|transcription factor complex;GO:0030425|dendrite;GO:0043025|neuronal cell body;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0046332|SMAD binding;GO:1990837|sequence-specific double-stranded DNA binding;",".","."]
["ENSRNOG00000014683",8,0.664213284,1,0.064330438,10.32502347,3.368073156,0.005310419,4.498592E-3,"up","yes","Il1rl2","protein_coding","chr9:42591934-42636667:+","gi|149046283|gb|EDL99176.1|",2955,0,"interleukin 1 receptor-like 2, isoform CRA_a [Rattus norvegicus]","gi|19424265|ref|NM_133575.1|",2027,0,"Rattus norvegicus interleukin 1 receptor-like 2 (Il1rl2), mRNA","Q62929",1135,0,"Interleukin-1 receptor-like 2",".",".",".",".","pfam01582","TIR","TIR domain. The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.","GO:0019221|cytokine-mediated signaling pathway;GO:0032755|positive regulation of interleukin-6 production;GO:0045582|positive regulation of T cell differentiation;GO:0050727|regulation of inflammatory response;","GO:0016021|integral component of membrane;","GO:0003953|NAD+ nucleosidase activity;GO:0004908|interleukin-1 receptor activity;GO:0050135|NAD(P)+ nucleosidase activity;GO:0061809|NAD+ nucleotidase, cyclic ADP-ribose generating;","K05172","IL1RL2, IL1RRP2; interleukin 1 receptor-like 2"]
["ENSRNOG00000036624",8,0.664213284,1,0.064330438,10.32502347,3.368073156,0.005310419,4.498592E-3,"up","yes","Oosp2","protein_coding","chr1:208484500-208496216:-","gi|564298892|ref|XP_006223718.1|",905,{"v":5e-122,"d":"5.00E-122"},"PREDICTED: oocyte-secreted protein 2 [Rattus norvegicus]","gi|672014696|ref|XM_006223656.2|",504,0,"PREDICTED: Rattus norvegicus oocyte secreted protein 2 (Oosp2), mRNA","Q4FZG8",259,{"v":6e-87,"d":"6.00E-87"},"Oocyte-secreted protein 2",".",".",".",".","pfam04592","SelP_N","Selenoprotein P, N terminal region. SelP is the only known eukaryotic selenoprotein that contains multiple selenocysteine (Sec) residues, and accounts for more than 50% of the selenium content of rat and human plasma. It is thought to be glycosylated. SelP may have antioxidant properties. It can attach to epithelial cells, and may protect vascular endothelial cells against peroxynitrite toxicity. The high selenium content of SelP suggests that it may be involved in selenium intercellular transport or storage. The promoter structure of bovine SelP suggest that it may be involved in countering heavy metal intoxication, and may also have a developmental function. The N-terminal region of SelP can exist independently of the C terminal region. Zebrafish selenoprotein Pb lacks the C terminal Sec-rich region, and a protein encoded by the rat SelP gene and lacking this region has also been reported. N-terminal region contains a conserved SecxxCys motif, which is similar to the CysxxCys found in thioredoxins. It is speculated that the N terminal region may adopt a thioredoxin fold and catalyse redox reactions. The N-terminal region also contains a His-rich region, which is thought to mediate heparin binding. Binding to heparan proteoglycans could account for the membrane binding properties of SelP. The function of the bacterial members of this family is uncharcterised.",".","GO:0005576|extracellular region;",".",".","."]
["ENSRNOG00000037097",8,0.664213284,1,0.064330438,10.32502347,3.368073156,0.005310419,4.498592E-3,"up","yes","Wfdc18","protein_coding","chr10:68588818-68589671:+","gi|312596878|ref|NP_598221.2|",328,{"v":8e-38,"d":"8.00E-38"},"WAP four-disulfide core domain protein 18 precursor [Rattus norvegicus]","gi|312596877|ref|NM_133537.2|",237,{"v":1E-119,"d":"1.00E-119"},"Rattus norvegicus WAP four-disulfide core domain 18 (Wfdc18), mRNA","P14730",127,{"v":4e-38,"d":"4.00E-38"},"WAP four-disulfide core domain protein 18 (Fragment)",".",".",".",".","pfam00095","WAP","WAP-type (Whey Acidic Protein) 'four-disulfide core'.","GO:0008150|biological_process;GO:0010951|negative regulation of endopeptidase activity;GO:0019731|antibacterial humoral response;GO:0043086|negative regulation of catalytic activity;GO:0045087|innate immune response;GO:0052547|regulation of peptidase activity;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0003674|molecular_function;GO:0004867|serine-type endopeptidase inhibitor activity;GO:0030414|peptidase inhibitor activity;",".","."]
["ENSRNOG00000070442",8,0.664213284,1,0.064330438,10.32502347,3.368073156,0.005310419,4.498592E-3,"up","yes","ENSRNOG00000070442","protein_coding","chr2:164256984-164322627:-","gi|74182426|dbj|BAE42843.1|",201,{"v":2e-17,"d":"2.00E-17"},"unnamed protein product [Mus musculus]","gi|672042698|ref|XM_008761098.1|",244,{"v":3e-123,"d":"3.00E-123"},"PREDICTED: Rattus norvegicus Rap guanine nucleotide exchange factor (GEF) 2 (Rapgef2), transcript variant X8, mRNA",".",".",".",".",".",".",".",".","pfam15634","Tox-ART-HYE1","HYE1 signature containing ADP-ribosyltransferase. A predicted toxin of the ADP-ribosyltransferase superfamily present in bacterial polymorphic toxin systems. The domain has characteristic histidine, tyrosine and glutamate residues that comprise the active site.",".",".",".",".","."]
["ENSRNOG00000069992",25,2.075666513,13,0.836295696,2.481976796,1.311489628,0.006137093,0.005145713,"up","yes","Sgpp2","protein_coding","chr9:79763284-79880457:+","gi|300796917|ref|NP_001178740.1|",1774,0,"sphingosine-1-phosphate phosphatase 2 [Rattus norvegicus]","gi|300796916|ref|NM_001191811.1|",1126,0,"Rattus norvegicus sphingosine-1-phosphate phosphatase 2 (Sgpp2), mRNA","Q810K3",664,0,"Sphingosine-1-phosphate phosphatase 2","YKR053c",76.3,{"v":3e-14,"d":"3.00E-14"},"COG0671","pfam01569","PAP2","PAP2 superfamily. This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidizing halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.",".",".",".",".","."]
["ENSRNOG00000003776",13,1.079346587,4,0.257321753,4.194540785,2.068512874,6.265006E-3,0.005244024,"up","yes","Amtn","protein_coding","chr14:19648625-19661181:-","gi|112983778|ref|NP_001037761.1|",852,{"v":5e-111,"d":"5.00E-111"},"amelotin precursor [Rattus norvegicus]","gi|112983777|ref|NM_001044296.1|",1001,0,"Rattus norvegicus amelotin (Amtn), mRNA","Q3HS82",332,{"v":2e-112,"d":"2.00E-112"},"Amelotin",".",".",".",".","pfam15424","ODAM","Odontogenic ameloblast-associated family.","GO:0007155|cell adhesion;GO:0031214|biomineral tissue development;GO:0042475|odontogenesis of dentin-containing tooth;GO:0070169|positive regulation of biomineral tissue development;GO:0070175|positive regulation of enamel mineralization;","GO:0005576|extracellular region;GO:0005604|basement membrane;GO:0005911|cell-cell junction;GO:0031012|extracellular matrix;","GO:0003674|molecular_function;","K25225","AMTN; amelotin"]
["ENSRNOG00000015623",13,1.079346587,4,0.257321753,4.194540785,2.068512874,6.265006E-3,0.005244024,"up","yes","Guca1b","protein_coding","chr9:13599619-13607455:-","gi|157816947|ref|NP_001101668.1|",1065,{"v":4e-140,"d":"4.00E-140"},"guanylyl cyclase-activating protein 2 [Rattus norvegicus]","gi|157816946|ref|NM_001108198.1|",1674,0,"Rattus norvegicus guanylate cyclase activator 1B (Guca1b), mRNA","Q8VBV8",402,{"v":8e-137,"d":"8.00E-137"},"Guanylyl cyclase-activating protein 2","SPAC18B11.04",127,{"v":8e-33,"d":"8.00E-33"},"COG5126","pfam13499","EF-hand_7","EF-hand domain pair.","GO:0007601|visual perception;GO:0007602|phototransduction;GO:0008150|biological_process;GO:0031282|regulation of guanylate cyclase activity;GO:0031284|positive regulation of guanylate cyclase activity;","GO:0001750|photoreceptor outer segment;GO:0001917|photoreceptor inner segment;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;GO:0008048|calcium sensitive guanylate cyclase activator activity;GO:0030249|guanylate cyclase regulator activity;","K08328","GUCA1; guanylate cyclase activator 1"]
["ENSRNOG00000070035",13,1.079346587,4,0.257321753,4.194540785,2.068512874,6.265006E-3,0.005244024,"up","yes","ENSRNOG00000070035","protein_coding","chrX:59701178-59703871:+","gi|532115188|ref|XP_005342256.1|",2978,0,"PREDICTED: zinc finger X-linked protein ZXDB-like [Ictidomys tridecemlineatus]","gi|672087761|ref|XM_006257042.2|",1772,0,"PREDICTED: Rattus norvegicus zinc finger, X-linked, duplicated B (Zxdb), transcript variant X2, mRNA","P98169",1064,0,"Zinc finger X-linked protein ZXDB","SPAC144.09c",117,{"v":3e-27,"d":"3.00E-27"},"COG5048","pfam13465","zf-H2C2_2","Zinc-finger double domain.",".",".",".",".","."]
["ENSRNOG00000001684",34,2.822906458,21,1.350939202,2.089588084,1.063218575,0.006836494,0.005671889,"up","yes","Ripply3","protein_coding","chr11:33648486-33656584:+","gi|157786836|ref|NP_001099362.1|",571,{"v":6E-68,"d":"6.00E-68"},"protein ripply3 [Rattus norvegicus]","gi|157786835|ref|NM_001105892.1|",1421,0,"Rattus norvegicus ripply transcriptional repressor 3 (Ripply3), mRNA","Q924S9",208,{"v":4e-63,"d":"4.00E-63"},"Protein ripply3",".",".",".",".","pfam14998","Ripply","Transcription Regulator. The precise function of this family is not clear, but it is thought to play a role in somitogenesis, development and transcriptional repression. Ripply is also known by an alternative name, Bowline. Bowline, is an associate protein of the transcriptional co-repressor XGrg-4. This family contains two conserved sequence motifs: WRPW and FPVQATI. The WRPW motif is thought to be required for binding to tle/groucho proteins. Ripply3 is also known as Down Syndrome Critical Region Protein 6 homolog. This family of proteins is found in eukaryotes. Proteins in this family are typically between 109 and 154 amino acids in length.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0007507|heart development;GO:0008285|negative regulation of cell proliferation;GO:0009880|embryonic pattern specification;GO:0060037|pharyngeal system development;","GO:0005634|nucleus;",".",".","."]
["ENSRNOG00000017986",34,2.822906458,21,1.350939202,2.089588084,1.063218575,0.006836494,0.005671889,"up","yes","Zfp458","protein_coding","chr2:84693186-84702558:+","gi|219282679|ref|NP_001136434.1|",3897,0,"zinc finger protein 458 isoform 1 [Rattus norvegicus]","gi|66730326|ref|NM_001024299.1|",3265,0,"Rattus norvegicus zinc finger protein 458 (Zfp458), transcript variant 2, mRNA","Q6P5C7",1270,0,"Zinc finger protein 728",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0046872|metal ion binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSRNOG00000008915",21,1.743559871,10,0.643304382,2.710318661,1.438462484,0.007043151,0.005828218,"up","yes","Prima1","protein_coding","chr6:122338370-122389921:-","gi|672056787|ref|XP_008763071.1|",877,{"v":3e-106,"d":"3.00E-106"},"PREDICTED: proline-rich membrane anchor 1 isoform X2 [Rattus norvegicus]","gi|672056786|ref|XM_008764849.1|",3518,0,"PREDICTED: Rattus norvegicus proline rich membrane anchor 1 (Prima1), transcript variant X1, mRNA","D3ZZP4",251,{"v":2e-75,"d":"2.00E-75"},"Proline-rich membrane anchor 1",".",".",".",".","pfam02500","DNA_pack_N","Probable DNA packing protein, N-terminus. This family includes proteins that are probably involved in DNA packing in herpesvirus. This domain is normally found at the N-terminus of the protein.","GO:0042135|neurotransmitter catabolic process;GO:0051649|establishment of localization in cell;","GO:0016021|integral component of membrane;GO:0031226|intrinsic component of plasma membrane;GO:0045202|synapse;","GO:0019899|enzyme binding;GO:0043495|protein membrane anchor;",".","."]
["ENSRNOG00000027582",35,2.905933118,22,1.41526964,2.053271713,1.037924554,0.007130744,0.005896885,"up","yes","Dpysl4","protein_coding","chr1:193883106-193898914:+","gi|158186661|ref|NP_037065.1|",3020,0,"dihydropyrimidinase-related protein 4 [Rattus norvegicus]","gi|158186660|ref|NM_012933.1|",2621,0,"Rattus norvegicus dihydropyrimidinase-like 4 (Dpysl4), mRNA","O35098",1159,0,"Dihydropyrimidinase-related protein 4","BMEI1644",412,{"v":4e-133,"d":"4.00E-133"},"COG0044","pfam01979","Amidohydro_1","Amidohydrolase family. This family of enzymes are a a large metal dependent hydrolase superfamily. The family includes Adenine deaminase EC:3.5.4.2 that hydrolyses adenine to form hypoxanthine and ammonia. Adenine deaminases reaction is important for adenine utilisation as a purine and also as a nitrogen source. This family also includes dihydroorotase and N-acetylglucosamine-6-phosphate deacetylases, EC:3.5.1.25 These enzymes catalyse the reaction N-acetyl-D-glucosamine 6-phosphate + H2O <=> D-glucosamine 6-phosphate + acetate. This family includes the catalytic domain of urease alpha subunit. Dihydroorotases (EC:3.5.2.3) are also included.","GO:0048666|neuron development;GO:0070997|neuron death;GO:0097485|neuron projection guidance;","GO:0005737|cytoplasm;","GO:0005515|protein binding;GO:0016810|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;GO:0031005|filamin binding;GO:0051219|phosphoprotein binding;",".","."]
["ENSRNOG00000066725",17,1.411453229,7,0.450313067,3.134382125,1.648181075,0.007385382,0.006083074,"up","yes","ENSRNOG00000066725","lncRNA","chr12:35013682-35014869:+","gi|149066508|gb|EDM16381.1|",202,{"v":6e-17,"d":"6.00E-17"},"rCG63686 [Rattus norvegicus]","gi|111038163|gb|AC130251.5|",123,{"v":1e-55,"d":"1.00E-55"},"Rattus norvegicus BAC CH230-157N23 () complete sequence",".",".",".",".",".",".",".",".","pfam10027","DUF2269","Predicted integral membrane protein (DUF2269). Members of this family of bacterial hypothetical integral membrane proteins have no known function.",".",".",".",".","."]
["ENSRNOG00000019129",22,1.826586532,11,0.70763482,2.581255868,1.368073156,0.007920589,0.006480495,"up","yes","Fcgbp","protein_coding","chr1:83372127-83413083:+","gi|695917199|ref|NP_001158129.2|",12945,0,"Fc fragment of IgG binding protein precursor [Rattus norvegicus]","gi|695917198|ref|NM_001164657.2|",7893,0,"Rattus norvegicus Fc fragment of IgG binding protein (Fcgbp), mRNA","Q9Y6R7",3427,0,"IgGFc-binding protein",".",".",".",".","pfam00094","VWD","von Willebrand factor type D domain. Luciferin-2-monooxygenase from Vargula hilgendorfii contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.",".","GO:0005615|extracellular space;GO:0031012|extracellular matrix;",".",".","."]
["ENSRNOG00000023640",22,1.826586532,11,0.70763482,2.581255868,1.368073156,0.007920589,0.006480495,"up","yes","Rab25","protein_coding","chr2:174000323-174006422:-","gi|164518908|ref|NP_001101157.2|",1132,{"v":6E-153,"d":"6.00E-153"},"ras-related protein Rab-25 [Rattus norvegicus]","gi|164518907|ref|NM_001107687.2|",1082,0,"Rattus norvegicus RAB25, member RAS oncogene family (Rab25), mRNA","Q9WTL2",435,{"v":2e-152,"d":"2.00E-152"},"Ras-related protein Rab-25","SPAC18G6.03",234,{"v":3e-74,"d":"3.00E-74"},"COG1100","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0003382|epithelial cell morphogenesis;GO:0006887|exocytosis;GO:0008284|positive regulation of cell proliferation;GO:0010634|positive regulation of epithelial cell migration;GO:0031268|pseudopodium organization;GO:0060627|regulation of vesicle-mediated transport;","GO:0005768|endosome;GO:0031143|pseudopodium;GO:0031410|cytoplasmic vesicle;GO:0055037|recycling endosome;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0031489|myosin V binding;","K07906","RAB25; Ras-related protein Rab-25"]
["ENSRNOG00000070751",22,1.826586532,11,0.70763482,2.581255868,1.368073156,0.007920589,0.006480495,"up","yes","ENSRNOG00000070751","lncRNA","chr16:32565278-32569912:-",".",".",".",".","gi|672029342|ref|XR_596984.1|",396,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102548619 (LOC102548619), ncRNA",".",".",".",".",".",".",".",".","pfam14631","FancD2","Fanconi anaemia protein FancD2 nuclease. The Fanconi anaemia protein FancD2 is a nuclease necessary for the repair of DNA interstrand-crosslinks.",".",".",".",".","."]
["ENSRNOG00000000446",11,0.913293266,3,0.192991315,4.732302425,2.242542274,0.008166737,0.006657186,"up","yes","Btnl7","protein_coding","chr20:4301854-4313274:+","gi|47059102|ref|NP_997653.1|",2803,0,"butyrophilin-like 7 [Rattus norvegicus]","gi|47059101|ref|NM_212488.1|",1818,0,"Rattus norvegicus butyrophilin-like 7 (Btnl7), mRNA","Q13410",353,{"v":2e-112,"d":"2.00E-112"},"Butyrophilin subfamily 1 member A1",".",".",".",".","pfam00622","SPRY","SPRY domain. SPRY Domain is named from SPla and the RYanodine Receptor. Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.","GO:0001817|regulation of cytokine production;GO:0050852|T cell receptor signaling pathway;","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0005102|signaling receptor binding;","K06712","BTN, CD277; butyrophilin"]
["ENSRNOG00000006732",11,0.913293266,3,0.192991315,4.732302425,2.242542274,0.008166737,0.006657186,"up","yes","Spo11","protein_coding","chr3:161757519-161770925:+","gi|564344772|ref|XP_006235760.1|",2096,0,"PREDICTED: meiotic recombination protein SPO11 isoform X1 [Rattus norvegicus]","gi|672048186|ref|XM_006235698.2|",1705,0,"PREDICTED: Rattus norvegicus SPO11 meiotic protein covalently bound to DSB (Spo11), transcript variant X1, mRNA","Q9WTK8",737,0,"Meiotic recombination protein SPO11","PAE2219",172,{"v":7e-47,"d":"7.00E-47"},"COG1697","pfam04406","TP6A_N","Type IIB DNA topoisomerase. Type II DNA topoisomerases are ubiquitous enzymes that catalyse the ATP-dependent transport of one DNA duplex through a second DNA segment via a transient double-strand break. Type II DNA topoisomerases are now subdivided into two sub-families, type IIA and IIB DNA topoisomerases. TP6A_N is present in type IIB topoisomerase and is thought to be involved in DNA binding owing to its sequence similarity to Escherichia coli catabolite activator protein (CAP).","GO:0000706|meiotic DNA double-strand break processing;GO:0001541|ovarian follicle development;GO:0007129|synapsis;GO:0007130|synaptonemal complex assembly;GO:0007131|reciprocal meiotic recombination;GO:0007141|male meiosis I;GO:0007286|spermatid development;GO:0034502|protein localization to chromosome;GO:0042138|meiotic DNA double-strand break formation;GO:0045141|meiotic telomere clustering;GO:0048477|oogenesis;GO:1990918|double-strand break repair involved in meiotic recombination;","GO:0000228|nuclear chromosome;GO:0000781|chromosome, telomeric region;","GO:0003677|DNA binding;GO:0003918|DNA topoisomerase type II (ATP-hydrolyzing) activity;GO:0005524|ATP binding;GO:0016787|hydrolase activity;GO:0046872|metal ion binding;","K10878","SPO11; meiotic recombination protein SPO11"]
["ENSRNOG00000010345",11,0.913293266,3,0.192991315,4.732302425,2.242542274,0.008166737,0.006657186,"up","yes","Ssmem1","protein_coding","chr4:59128730-59145007:+","gi|157823083|ref|NP_001102698.1|",960,{"v":3e-125,"d":"3.00E-125"},"serine-rich single-pass membrane protein 1 [Rattus norvegicus]","gi|157823082|ref|NM_001109228.1|",1484,0,"Rattus norvegicus serine-rich single-pass membrane protein 1 (Ssmem1), mRNA","Q4R309",201,{"v":5e-59,"d":"5.00E-59"},"Serine-rich single-pass membrane protein 1",".",".",".",".","pfam15468","DUF4636","Domain of unknown function (DUF4636). This family of proteins is found in eukaryotes. Proteins in this family are typically between 196 and 244 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000010932",11,0.913293266,3,0.192991315,4.732302425,2.242542274,0.008166737,0.006657186,"up","yes","Matn1","protein_coding","chr5:143117504-143127059:+","gi|55741484|ref|NP_001006980.1|",2520,0,"cartilage matrix protein precursor [Rattus norvegicus]","gi|55741483|ref|NM_001006979.1|",1889,0,"Rattus norvegicus matrilin 1, cartilage matrix protein (Matn1), mRNA","P51942",928,0,"Cartilage matrix protein",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0002062|chondrocyte differentiation;GO:0003429|growth plate cartilage chondrocyte morphogenesis;GO:0030500|regulation of bone mineralization;","GO:0031012|extracellular matrix;GO:0062023|collagen-containing extracellular matrix;","GO:0005201|extracellular matrix structural constituent;GO:0005509|calcium ion binding;","K19467","MATN; matrilin"]
["ENSRNOG00000052327",11,0.913293266,3,0.192991315,4.732302425,2.242542274,0.008166737,0.006657186,"up","yes","U2","snRNA","chr3:143781974-143782150:+",".",".",".",".","gi|298161016|gb|AC234826.3|",54,{"v":4e-18,"d":"4.00E-18"},"Ochotona princeps clone VMRC40-45K5, complete sequence",".",".",".",".",".",".",".",".","pfam14826","FACT-Spt16_Nlob","FACT complex subunit SPT16 N-terminal lobe domain. The FACT or facilitator of chromatin transcription complex binds to and alters the properties of nucleosomes. This family represents the N-terminal lobe of the NTD, or N-terminal domain, and acts as a protein-protein interaction domain presumably with partners outside of the FACT complex. Knockout of the whole NTD domain, 1-450 residues in UniProt:P32558, in yeast serves to tender the cells sensitive to DNA replication stress but is not lethal. The C-terminal half of NTD is structurally similar to aminopeptidases, and the most highly conserved surface residues line a cleft equivalent to the aminopeptidase substrate-binding site, family peptidase_M24, pfam00557.",".",".",".",".","."]
["ENSRNOG00000070004",11,0.913293266,3,0.192991315,4.732302425,2.242542274,0.008166737,0.006657186,"up","yes","ENSRNOG00000070004","protein_coding","chrX:47263245-47264783:+","gi|564382614|ref|XP_006250647.1|",996,{"v":5e-133,"d":"5.00E-133"},"PREDICTED: 60S ribosomal protein L5 isoform X1 [Rattus norvegicus]","gi|959092969|ref|NG_046264.1|",660,0,"Rattus norvegicus 60S ribosomal protein L5-like (LOC102551195) pseudogene on chromosome X","P22451",385,{"v":3e-133,"d":"3.00E-133"},"60S ribosomal protein L5","YPL131w",184,{"v":2E-55,"d":"2.00E-55"},"COG0256","pfam14204","Ribosomal_L18_c","Ribosomal L18 C-terminal region. This domain is the C-terminal end of ribosomal L18/L5 proteins.",".",".",".",".","."]
["ENSRNOG00000026974",14,1.162373247,5,0.321652191,3.613758215,1.853499983,0.008329966,0.006779008,"up","yes","Dbndd1","protein_coding","chr19:51539148-51548444:-","gi|81883079|sp|Q5M831.1|DBND1_RAT",766,{"v":6e-94,"d":"6.00E-94"},"RecName: Full=Dysbindin domain-containing protein 1","gi|62079046|ref|NM_001014156.1|",1454,0,"Rattus norvegicus dysbindin (dystrobrevin binding protein 1) domain containing 1 (Dbndd1), mRNA","Q5M831",299,{"v":2E-95,"d":"2.00E-95"},"Dysbindin domain-containing protein 1",".",".",".",".","pfam04440","Dysbindin","Dysbindin (Dystrobrevin binding protein 1). Dysbindin is an evolutionary conserved 40-kDa coiled-coil-containing protein that binds to alpha- and beta-dystrobrevin in muscle and brain. Dystrophin and alpha-dystrobrevin are co-immunoprecipitated with dysbindin, indicating that dysbindin is DPC-associated in muscle. Dysbindin co-localizes with alpha-dystrobrevin at the sarcolemma and is up-regulated in dystrophin-deficient muscle. In the brain, dysbindin is found primarily in axon bundles and especially in certain axon terminals, notably mossy fibre synaptic terminals in the cerebellum and hippocampus. Dysbindin may have implications for the molecular pathology of Duchenne muscular dystrophy and may provide an alternative route for anchoring dystrobrevin and the DPC to the muscle membrane. Genetic variation in the human dysbindin gene is also thought to be associated with Schizophrenia.","GO:0006469|negative regulation of protein kinase activity;","GO:0005737|cytoplasm;",".",".","."]
["ENSRNOG00000028751",14,1.162373247,5,0.321652191,3.613758215,1.853499983,0.008329966,0.006779008,"up","yes","Nxf3","protein_coding","chrX:99025901-99039261:-","gi|672088164|ref|XP_008771631.1|",2983,0,"PREDICTED: nuclear RNA export factor 3 isoform X1 [Rattus norvegicus]","gi|672088171|ref|XM_006257271.2|",3012,0,"PREDICTED: Rattus norvegicus nuclear RNA export factor 3 (Nxf3), transcript variant X5, mRNA","Q9H4D5",528,{"v":4E-175,"d":"4.00E-175"},"Nuclear RNA export factor 3",".",".",".",".","pfam09162","Tap-RNA_bind","Tap, RNA-binding. Members of this family adopt a structure consisting of an alpha+beta sandwich with an antiparallel beta-sheet, arranged in a 2(beta-alpha-beta) motif. They are mainly found in mRNA export factors, and mediate the sequence nonspecific nuclear export of cellular mRNAs as well as the sequence-specific export of retroviral mRNAs bearing the constitutive transport element.","GO:0006406|mRNA export from nucleus;GO:0008150|biological_process;GO:0016973|poly(A)+ mRNA export from nucleus;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0042272|nuclear RNA export factor complex;","GO:0003674|molecular_function;GO:0003723|RNA binding;GO:0003729|mRNA binding;","K14284","NXF, TAP, MEX67; nuclear RNA export factor"]
["ENSRNOG00000067111",14,1.162373247,5,0.321652191,3.613758215,1.853499983,0.008329966,0.006779008,"up","yes","ENSRNOG00000067111","protein_coding","chr14:13850057-13852806:-","gi|672027701|ref|XP_008762845.1|",999,{"v":7e-132,"d":"7.00E-132"},"PREDICTED: PRAME family member 12-like isoform X1 [Rattus norvegicus]","gi|672027702|ref|XM_002724946.2|",566,0,"PREDICTED: Rattus norvegicus similar to PRAME family member 9 (LOC685782), transcript variant X2, mRNA","O95522",144,{"v":8e-38,"d":"8.00E-38"},"PRAME family member 12",".",".",".",".","pfam12799","LRR_4","Leucine Rich repeats (2 copies). Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.",".",".",".",".","."]
["ENSRNOG00000067729",14,1.162373247,5,0.321652191,3.613758215,1.853499983,0.008329966,0.006779008,"up","yes","ENSRNOG00000067729","lncRNA","chr7:67733989-67753442:-","gi|928078377|ref|XP_013889234.1|",345,{"v":8e-33,"d":"8.00E-33"},"PREDICTED: putative uncharacterized protein DDB_G0290521 [Austrofundulus limnaeus]","gi|672021791|ref|XR_601783.1|",4245,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103692886 (LOC103692886), ncRNA",".",".",".",".",".",".",".",".","pfam02093","Gag_p30","Gag P30 core shell protein. According to Swiss-Prot annotation this protein is the viral core shell protein. P30 is essential for viral assembly.",".",".",".",".","."]
["ENSRNOG00000071173",14,1.162373247,5,0.321652191,3.613758215,1.853499983,0.008329966,0.006779008,"up","yes","ENSRNOG00000071173","lncRNA","chr5:110105851-110250770:-",".",".",".",".","gi|28949312|emb|AL954135.7|",427,0,"Mouse DNA sequence from clone RP23-231H10 on chromosome 4, complete sequence",".",".",".",".",".",".",".",".","pfam13933","HRXXH","Putative peptidase family. This family of putative peptidases are closely related to the M35 family pfam02102. In this family the metal binding HEXXH motif is replaced with HRXXH. The exact function of these proteins is unknown. Members of this family are found to be fungal allergens.",".",".",".",".","."]
["ENSRNOG00000010365",18,1.494479889,8,0.514643505,2.903912851,1.537998158,0.008743647,0.007084108,"up","yes","Syn1","protein_coding","chrX:1172208-1227396:+","gi|9507159|ref|NP_062006.1|",2252,0,"synapsin-1 isoform a [Rattus norvegicus]","gi|403067935|ref|NM_019133.2|",3166,0,"Rattus norvegicus synapsin I (Syn1), transcript variant 1, mRNA","P09951",872,0,"Synapsin-1",".",".",".",".","pfam02750","Synapsin_C","Synapsin, ATP binding domain. Ca dependent ATP binding in this ATP grasp fold. Function unknown.","GO:0007269|neurotransmitter secretion;GO:0048666|neuron development;GO:0050808|synapse organization;GO:0097091|synaptic vesicle clustering;GO:0098693|regulation of synaptic vesicle cycle;GO:0099504|synaptic vesicle cycle;","GO:0000795|synaptonemal complex;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0008021|synaptic vesicle;GO:0014069|postsynaptic density;GO:0030424|axon;GO:0030425|dendrite;GO:0030672|synaptic vesicle membrane;GO:0043195|terminal bouton;GO:0043229|intracellular organelle;GO:0045202|synapse;GO:0048786|presynaptic active zone;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098793|presynapse;GO:0098850|extrinsic component of synaptic vesicle membrane;GO:0098993|anchored component of synaptic vesicle membrane;","GO:0003779|actin binding;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0019901|protein kinase binding;GO:0042802|identical protein binding;GO:0048306|calcium-dependent protein binding;","K19941","SYN; synapsin"]
["ENSRNOG00000056017",18,1.494479889,8,0.514643505,2.903912851,1.537998158,0.008743647,0.007084108,"up","yes","ENSRNOG00000056017","protein_coding","chr12:33223931-33243886:-","gi|148687692|gb|EDL19639.1|",570,{"v":8e-68,"d":"8.00E-68"},"B-cell CLL/lymphoma 7A, isoform CRA_a, partial [Mus musculus]","gi|672026720|ref|XM_006221347.2|",560,0,"PREDICTED: Rattus norvegicus similar to B-cell CLL/lymphoma 7A (LOC690085), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam04714","BCL_N","BCL7, N-terminal conserver region. Members of the BCL family have significant sequence similarity at their N-terminus, represented in this family. The function of BCL7 proteins is unknown. They may be involved in early development. In addition, BCL7B is commonly hemizygously deleted in patients with Williams syndrome.",".",".",".","K25605","BCL7; B-cell CLL/lymphoma 7 protein"]
["ENSRNOG00000070411",18,1.494479889,8,0.514643505,2.903912851,1.537998158,0.008743647,0.007084108,"up","yes","ENSRNOG00000070411","lncRNA","chr3:65274032-65275043:-","gi|149066508|gb|EDM16381.1|",194,{"v":6e-16,"d":"6.00E-16"},"rCG63686 [Rattus norvegicus]","gi|163943533|gb|AC096430.6|",138,{"v":6e-64,"d":"6.00E-64"},"Rattus norvegicus BAC CH230-155O11 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam10243","MIP-T3","Microtubule-binding protein MIP-T3. This protein, which interacts with both microtubules and TRAF3 (tumor necrosis factor receptor-associated factor 3), is conserved from worms to humans. The N-terminal region is the microtubule binding domain and is well-conserved; the C-terminal 100 residues, also well-conserved, constitute the coiled-coil region which binds to TRAF3. The central region of the protein is rich in lysine and glutamic acid and carries KKE motifs which may also be necessary for tubulin-binding, but this region is the least well-conserved.",".",".",".",".","."]
["ENSRNOG00000005054",30,2.490799816,18,1.157947887,2.151046557,1.10503875,0.008754542,0.007089343,"up","yes","Prox2","protein_coding","chr6:104733002-104742093:-","gi|300796107|ref|NP_001178700.1|",3017,0,"prospero homeobox protein 2 [Rattus norvegicus]","gi|300796106|ref|NM_001191771.1|",1782,0,"Rattus norvegicus prospero homeobox 2 (Prox2), mRNA","Q8BII1",1004,0,"Prospero homeobox protein 2",".",".",".",".","pfam05044","HPD","Homeo-prospero domain. Prospero is a large drosophila transcription factor protein that is expressed in all neural lineages of drosophila embryos. It is needed for correct expression of several neural proteins and in determining the cell fates of neural stem cells. Homologues of prospero are found in a wide range of animals including humans with the highest level of similarity being found in the C-terminal 160 amino acids. This region was identified as containing an atypical homeobox domain followed by a prospero domain. However, the structure shows that these two regions form a single stable structural domain as defined here. This homeo-prospero domain binds to DNA.","GO:0006357|regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;","K20212","PROX2; prospero homeobox 2"]
["ENSRNOG00000018321",30,2.490799816,18,1.157947887,2.151046557,1.10503875,0.008754542,0.007089343,"up","yes","Sytl3","protein_coding","chr1:46911217-46967460:+","gi|564325240|ref|XP_006227950.1|",3280,0,"PREDICTED: synaptotagmin-like protein 3 isoform X2 [Rattus norvegicus]","gi|672034315|ref|XM_006227888.2|",2211,0,"PREDICTED: Rattus norvegicus synaptotagmin-like 3 (Sytl3), transcript variant X1, mRNA","Q99N48",1152,0,"Synaptotagmin-like protein 3",".",".",".",".","pfam02318","FYVE_2","FYVE-type zinc finger. This FYVE-type zinc finger is found at the N-terminus of effector proteins including rabphilin-3A and regulating synaptic membrane exocytosis protein 2.","GO:0006886|intracellular protein transport;GO:0006887|exocytosis;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0019897|extrinsic component of plasma membrane;GO:0070382|exocytic vesicle;","GO:0005543|phospholipid binding;GO:0005544|calcium-dependent phospholipid binding;GO:0031267|small GTPase binding;GO:0042043|neurexin family protein binding;","K17598","SYTL; synaptotagmin-like protein"]
["ENSRNOG00000019613",30,2.490799816,18,1.157947887,2.151046557,1.10503875,0.008754542,0.007089343,"up","yes","Syt9","protein_coding","chr1:161275734-161455007:+","gi|564330267|ref|XP_006230023.1|",2232,0,"PREDICTED: synaptotagmin-9 isoform X2 [Rattus norvegicus]","gi|755522995|ref|XR_378262.2|",1999,0,"PREDICTED: Mus musculus synaptotagmin IX (Syt9), transcript variant X1, misc_RNA","Q925C0",860,0,"Synaptotagmin-9","SPCP31B10.06",55.1,1e-06,"COG5038","pfam00168","C2","C2 domain.","GO:0005513|detection of calcium ion;GO:0014059|regulation of dopamine secretion;GO:0016192|vesicle-mediated transport;GO:0017156|calcium ion regulated exocytosis;GO:0017158|regulation of calcium ion-dependent exocytosis;GO:0045956|positive regulation of calcium ion-dependent exocytosis;GO:0050796|regulation of insulin secretion;GO:0071277|cellular response to calcium ion;GO:0099502|calcium-dependent activation of synaptic vesicle fusion;","GO:0005886|plasma membrane;GO:0030141|secretory granule;GO:0030285|integral component of synaptic vesicle membrane;GO:0030667|secretory granule membrane;GO:0031045|dense core granule;GO:0070382|exocytic vesicle;GO:0098686|hippocampal mossy fiber to CA3 synapse;","GO:0000149|SNARE binding;GO:0001786|phosphatidylserine binding;GO:0005509|calcium ion binding;GO:0005544|calcium-dependent phospholipid binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0019905|syntaxin binding;GO:0030276|clathrin binding;GO:0042802|identical protein binding;","K19909","SYT9; synaptotagmin-9"]
["ENSRNOG00000055777",30,2.490799816,18,1.157947887,2.151046557,1.10503875,0.008754542,0.007089343,"up","yes","AABR07064980.1","protein_coding","chr6:98809534-98809897:-","gi|507677505|ref|XP_004709931.1|",473,{"v":1E-58,"d":"1.00E-58"},"PREDICTED: 60S ribosomal protein L36-like [Echinops telfairi]","gi|34849735|gb|BC058475.1|",345,{"v":2E-179,"d":"2.00E-179"},"Rattus norvegicus ribosomal protein L36, mRNA (cDNA clone MGC:72835 IMAGE:6888196), complete cds","Q5RAZ9",183,{"v":5e-59,"d":"5.00E-59"},"60S ribosomal protein L36","SPCC970.05",96.3,{"v":2e-25,"d":"2.00E-25"},"COG5051","pfam01158","Ribosomal_L36e","Ribosomal protein L36e.",".",".",".",".","."]
["ENSRNOG00000068444",23,1.909613192,12,0.771965258,2.47370354,1.306672612,0.008767261,0.007098743,"up","yes","Kcnj10","protein_coding","chr13:84802009-84835461:+","gi|564381811|ref|XP_006250347.1|",1942,0,"PREDICTED: ATP-sensitive inward rectifier potassium channel 10 isoform X2 [Rattus norvegicus]","gi|672074769|ref|XM_006250285.2|",2066,0,"PREDICTED: Rattus norvegicus potassium inwardly-rectifying channel, subfamily J, member 10 (Kcnj10), transcript variant X1, mRNA","P49655",747,0,"ATP-sensitive inward rectifier potassium channel 10",".",".",".",".","pfam01007","IRK","Inward rectifier potassium channel.",".",".",".",".","."]
["ENSRNOG00000022640",31,2.573826476,19,1.222278326,2.105761366,1.074341953,0.009197645,0.007391064,"up","yes","Siglec8","protein_coding","chr1:94093395-94103034:-","gi|149056112|gb|EDM07543.1|",2413,0,"rCG54314 [Rattus norvegicus]","gi|672013506|ref|XR_342908.2|",2436,0,"PREDICTED: Rattus norvegicus sialic acid binding Ig-like lectin 8 (Siglec8), transcript variant X1, misc_RNA","Q91Y57",726,0,"Sialic acid-binding Ig-like lectin 12",".",".",".",".","pfam08205","C2-set_2","CD80-like C2-set immunoglobulin domain. These domains belong to the immunoglobulin superfamily.","GO:0007155|cell adhesion;GO:0050728|negative regulation of inflammatory response;GO:0060101|negative regulation of phagocytosis, engulfment;","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0033691|sialic acid binding;GO:0048029|monosaccharide binding;",".","."]
["ENSRNOG00000026309",31,2.573826476,19,1.222278326,2.105761366,1.074341953,0.009197645,0.007391064,"up","yes","Lrrc23","protein_coding","chr4:157581291-157591860:-","gi|564348949|ref|XP_006237422.1|",1184,{"v":6e-156,"d":"6.00E-156"},"PREDICTED: leucine-rich repeat-containing protein 23 isoform X2 [Rattus norvegicus]","gi|672051038|ref|XM_006237360.2|",1413,0,"PREDICTED: Rattus norvegicus leucine rich repeat containing 23 (Lrrc23), transcript variant X4, mRNA",".",".",".",".","CAC3274_2",81.3,{"v":1e-15,"d":"1.00E-15"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.",".","GO:0005829|cytosol;",".",".","."]
["ENSRNOG00000066614",24,1.992639853,13,0.836295696,2.382697724,1.252595939,0.009577218,0.007648979,"up","yes","RGD1561143","protein_coding","chr12:17723741-17828007:-","gi|672033438|ref|XP_008756447.1|",979,{"v":7e-119,"d":"7.00E-119"},"PREDICTED: LOW QUALITY PROTEIN: paired immunoglobulin-like type 2 receptor beta isoform X1 [Rattus norvegicus]","gi|672033573|ref|XR_589536.1|",2250,0,"PREDICTED: Rattus norvegicus similar to Zinc finger, CW type with PWWP domain 1 (RGD1566138), transcript variant X1, misc_RNA","Q6IR42",271,{"v":3e-76,"d":"3.00E-76"},"Zinc finger CW-type PWWP domain protein 1",".",".",".",".","pfam07496","zf-CW","CW-type Zinc Finger. This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a \"highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development.\" Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteristic of vertebrates, higher plants and other animals in which these domain is found.",".",".",".",".","."]
["ENSRNOG00000024230",19,1.57750655,9,0.578973944,2.724658972,1.446075668,0.010069537,0.007990279,"up","yes","Tnfaip8l3","protein_coding","chr8:54414457-54500079:-","gi|880879841|ref|XP_005069605.2|",1170,{"v":8e-156,"d":"8.00E-156"},"PREDICTED: LOW QUALITY PROTEIN: tumor necrosis factor alpha-induced protein 8-like protein 3 [Mesocricetus auratus]","gi|672022818|ref|XM_006226402.2|",1218,0,"PREDICTED: Rattus norvegicus tumor necrosis factor, alpha-induced protein 8-like 3 (Tnfaip8l3), transcript variant X2, mRNA","Q3TBL6",412,{"v":1E-142,"d":"1.00E-142"},"Tumor necrosis factor alpha-induced protein 8-like protein 3",".",".",".",".","pfam05527","DUF758","Domain of unknown function (DUF758). Family of eukaryotic proteins with unknown function, which are induced by tumor necrosis factor.","GO:0015914|phospholipid transport;GO:0019216|regulation of lipid metabolic process;GO:0042981|regulation of apoptotic process;GO:0043552|positive regulation of phosphatidylinositol 3-kinase activity;GO:0048017|inositol lipid-mediated signaling;GO:0051897|positive regulation of protein kinase B signaling;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0120009|intermembrane lipid transfer;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0008526|phosphatidylinositol transporter activity;GO:0035091|phosphatidylinositol binding;",".","."]
["ENSRNOG00000070916",19,1.57750655,9,0.578973944,2.724658972,1.446075668,0.010069537,0.007990279,"up","yes","Hist1h2bo","protein_coding","chr17:42673067-42718095:-","gi|4504269|ref|NP_003515.1|",479,{"v":2e-54,"d":"2.00E-54"},"histone H2B type 1-H [Homo sapiens]","gi|157817104|ref|NM_001106114.1|",377,0,"Rattus norvegicus histone cluster 1, H2bo (Hist1h2bo), mRNA","Q93079",189,{"v":6e-56,"d":"6.00E-56"},"Histone H2B type 1-H",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.",".",".",".",".","."]
["ENSRNOG00000010480",9,0.747239945,2,0.128660876,5.807825703,2.537998158,0.010092102,0.008002226,"up","yes","Vstm5","protein_coding","chr8:12080203-12100427:+","gi|56789732|gb|AAH88439.1|",993,{"v":2e-128,"d":"2.00E-128"},"LOC500947 protein [Rattus norvegicus]","gi|221554521|ref|NM_001144870.1|",1849,0,"Rattus norvegicus V-set and transmembrane domain containing 5 (Vstm5), mRNA","Q5M7U7",376,{"v":7E-126,"d":"7.00E-126"},"V-set and transmembrane domain-containing protein 5",".",".",".",".","pfam01500","Keratin_B2","Keratin, high sulfur B2 protein. High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.","GO:0021517|ventral spinal cord development;GO:0046847|filopodium assembly;GO:0051260|protein homooligomerization;GO:1904891|positive regulation of excitatory synapse assembly;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0030425|dendrite;",".",".","."]
["ENSRNOG00000030927",9,0.747239945,2,0.128660876,5.807825703,2.537998158,0.010092102,0.008002226,"up","yes","Grid2ip","protein_coding","chr12:11167874-11203676:-","gi|564378222|ref|XP_006248928.1|",4961,0,"PREDICTED: delphilin isoform X1 [Rattus norvegicus]","gi|672071931|ref|XM_006248866.2|",3933,0,"PREDICTED: Rattus norvegicus glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein (Grid2ip), transcript variant X1, mRNA","Q0QWG9",1864,0,"Delphilin",".",".",".",".","pfam02181","FH2","Formin Homology 2 Domain.","GO:0060292|long-term synaptic depression;","GO:0043197|dendritic spine;GO:0045202|synapse;",".",".","."]
["ENSRNOG00000032951",9,0.747239945,2,0.128660876,5.807825703,2.537998158,0.010092102,0.008002226,"up","yes","Jsrp1","protein_coding","chr7:8901609-8906055:+","gi|157819085|ref|NP_001103061.1|",767,{"v":2E-95,"d":"2.00E-95"},"junctional sarcoplasmic reticulum protein 1 [Rattus norvegicus]","gi|157819084|ref|NM_001109591.1|",1085,0,"Rattus norvegicus junctional sarcoplasmic reticulum protein 1 (Jsrp1), mRNA","Q3MI48",226,{"v":1e-68,"d":"1.00E-68"},"Junctional sarcoplasmic reticulum protein 1",".",".",".",".","pfam15312","JSRP","Junctional sarcoplasmic reticulum protein. JSRP, junctional sarcoplasmic reticulum protein 1, or junctional-face membrane protein of 45 kDa homologue, is a family of eukaryotic proteins. The family is to the junctional face membrane of the skeletal muscle sarcoplasmic reticulum (SR); it colocalizes with its Ca2+-release channel (the ryanodine receptor), and interacts with calsequestrin and the skeletal-muscle dihydro-pyridine receptor Cav1. It is key for the functional expression of voltage-dependent Ca2+ channels.","GO:0003009|skeletal muscle contraction;GO:0060314|regulation of ryanodine-sensitive calcium-release channel activity;GO:0072657|protein localization to membrane;","GO:0016529|sarcoplasmic reticulum;",".",".","."]
["ENSRNOG00000050996",9,0.747239945,2,0.128660876,5.807825703,2.537998158,0.010092102,0.008002226,"up","yes","Kctd4","protein_coding","chr15:51274295-51277499:+","gi|157820721|ref|NP_001103120.1|",1305,{"v":8e-169,"d":"8.00E-169"},"BTB/POZ domain-containing protein KCTD4 [Rattus norvegicus]","gi|672078799|ref|XM_006252330.2|",3205,0,"PREDICTED: Rattus norvegicus potassium channel tetramerization domain containing 4 (Kctd4), transcript variant X1, mRNA","Q9D7X1",499,{"v":4E-167,"d":"4.00E-167"},"BTB/POZ domain-containing protein KCTD4",".",".",".",".","pfam02214","BTB_2","BTB/POZ domain. In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.","GO:0051260|protein homooligomerization;",".",".",".","."]
["ENSRNOG00000063116",9,0.747239945,2,0.128660876,5.807825703,2.537998158,0.010092102,0.008002226,"up","yes","ENSRNOG00000063116","snoRNA","chr7:129676333-129676469:-","gi|674056928|ref|XP_008834972.1|",141,6E-9,"PREDICTED: DNA-directed RNA polymerase I subunit RPA1 isoform X2 [Nannospalax galili]","gi|291327552|gb|AC142003.2|",127,{"v":8e-59,"d":"8.00E-59"},"Rattus norvegicus BAC CH230-241B5 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam05280","FlhC","Flagellar transcriptional activator (FlhC). This family consists of several bacterial flagellar transcriptional activator (FlhC) proteins. FlhC combines with FlhD to form a regulatory complex in Escherichia coli, this complex has been shown to be a global regulator involved in many cellular processes as well as a flagellar transcriptional activator.",".",".",".",".","."]
["ENSRNOG00000067200",9,0.747239945,2,0.128660876,5.807825703,2.537998158,0.010092102,0.008002226,"up","yes","ENSRNOG00000067200","lncRNA","chr2:76323450-76328412:-",".",".",".",".","gi|46309642|gb|AC134786.6|",369,0,"Mus musculus chromosome 15, clone RP24-502A14, complete sequence",".",".",".",".",".",".",".",".","pfam08594","UPF0300","Uncharacterized protein family (UPF0300). This family of proteins appear to be specific to S. pombe.",".",".",".",".","."]
["ENSRNOG00000001117",25,2.075666513,14,0.900626135,2.304692739,1.204574424,0.010346404,0.008189648,"up","yes","Fbxl18","protein_coding","chr12:11676115-11699181:+","gi|568938701|ref|XP_006504756.1|",3656,0,"PREDICTED: F-box/LRR-repeat protein 18 isoform X1 [Mus musculus]","gi|672072297|ref|XM_006248907.2|",2760,0,"PREDICTED: Rattus norvegicus F-box and leucine-rich repeat protein 18 (Fbxl18), transcript variant X3, mRNA","Q96ME1",1127,0,"F-box/LRR-repeat protein 18",".",".",".",".","pfam12937","F-box-like","F-box-like. This is an F-box-like family.","GO:0031146|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;","GO:0019005|SCF ubiquitin ligase complex;",".","K10284","FBXL18; F-box and leucine-rich repeat protein 18"]
["ENSRNOG00000016571",25,2.075666513,14,0.900626135,2.304692739,1.204574424,0.010346404,0.008189648,"up","yes","Ngf","protein_coding","chr2:189901058-189954452:+","gi|537265807|gb|ERE90958.1|",1489,0,"beta-nerve growth factor-like protein [Cricetulus griseus]","gi|456367245|ref|NM_001277055.1|",862,0,"Rattus norvegicus nerve growth factor (beta polypeptide) (Ngf), mRNA","P25427",499,{"v":2E-175,"d":"2.00E-175"},"Beta-nerve growth factor",".",".",".",".","pfam00243","NGF","Nerve growth factor family.","GO:0001934|positive regulation of protein phosphorylation;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006954|inflammatory response;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007171|activation of transmembrane receptor protein tyrosine kinase activity;GO:0007422|peripheral nervous system development;GO:0007568|aging;GO:0007613|memory;GO:0007623|circadian rhythm;GO:0008284|positive regulation of cell proliferation;GO:0008344|adult locomotory behavior;GO:0008625|extrinsic apoptotic signaling pathway via death domain receptors;GO:0009314|response to radiation;GO:0009410|response to xenobiotic stimulus;GO:0009612|response to mechanical stimulus;GO:0010033|response to organic substance;GO:0010193|response to ozone;GO:0010628|positive regulation of gene expression;GO:0010951|negative regulation of endopeptidase activity;GO:0010976|positive regulation of neuron projection development;GO:0014042|positive regulation of neuron maturation;GO:0014070|response to organic cyclic compound;GO:0019233|sensory perception of pain;GO:0021675|nerve development;GO:0030307|positive regulation of cell growth;GO:0031175|neuron projection development;GO:0031398|positive regulation of protein ubiquitination;GO:0031954|positive regulation of protein autophosphorylation;GO:0032092|positive regulation of protein binding;GO:0032496|response to lipopolysaccharide;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0035094|response to nicotine;GO:0038180|nerve growth factor signaling pathway;GO:0043388|positive regulation of DNA binding;GO:0043434|response to peptide hormone;GO:0043524|negative regulation of neuron apoptotic process;GO:0045664|regulation of neuron differentiation;GO:0045666|positive regulation of neuron differentiation;GO:0045773|positive regulation of axon extension;GO:0046579|positive regulation of Ras protein signal transduction;GO:0046928|regulation of neurotransmitter secretion;GO:0048666|neuron development;GO:0048672|positive regulation of collateral sprouting;GO:0048812|neuron projection morphogenesis;GO:0050804|modulation of chemical synaptic transmission;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051279|regulation of release of sequestered calcium ion into cytosol;GO:0051384|response to glucocorticoid;GO:0051388|positive regulation of neurotrophin TRK receptor signaling pathway;GO:0051402|neuron apoptotic process;GO:0051602|response to electrical stimulus;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0097192|extrinsic apoptotic signaling pathway in absence of ligand;GO:1902236|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:2000648|positive regulation of stem cell proliferation;GO:2000675|negative regulation of type B pancreatic cell apoptotic process;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005788|endoplasmic reticulum lumen;GO:0005796|Golgi lumen;GO:0008021|synaptic vesicle;GO:0030424|axon;GO:0030425|dendrite;GO:0031904|endosome lumen;GO:0044306|neuron projection terminus;","GO:0003674|molecular_function;GO:0005163|nerve growth factor receptor binding;GO:0008083|growth factor activity;GO:0008191|metalloendopeptidase inhibitor activity;GO:0008289|lipid binding;GO:0008656|cysteine-type endopeptidase activator activity involved in apoptotic process;GO:0030297|transmembrane receptor protein tyrosine kinase activator activity;GO:0038177|death receptor agonist activity;","K02582","NGFB; nerve growth factor, beta"]
["ENSRNOG00000036670",25,2.075666513,14,0.900626135,2.304692739,1.204574424,0.010346404,0.008189648,"up","yes","Tex19.1","protein_coding","chr10:106420139-106422425:+","gi|62945320|ref|NP_001017482.1|",1645,0,"testis-expressed protein 19.1 [Rattus norvegicus]","gi|62945319|ref|NM_001017482.1|",1700,0,"Rattus norvegicus testis expressed 19.1 (Tex19.1), mRNA","Q5XHY3",638,0,"Testis-expressed protein 19.1",".",".",".",".","pfam15553","TEX19","Testis-expressed protein 19. This family of proteins is expressed in testis.","GO:0001890|placenta development;GO:0007131|reciprocal meiotic recombination;GO:0007140|male meiotic nuclear division;GO:0007283|spermatogenesis;GO:0008584|male gonad development;GO:0010529|negative regulation of transposition;GO:0030154|cell differentiation;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0034584|piRNA binding;",".","."]
["ENSRNOG00000002976",15,1.245399908,6,0.385982629,3.226569835,1.690001251,0.010417538,0.008235759,"up","yes","Cfap91","protein_coding","chr11:62413602-62457293:+","gi|672026095|ref|XP_008774914.1|",4030,0,"PREDICTED: protein MAATS1, partial [Rattus norvegicus]","gi|672026094|ref|XM_008776692.1|",2900,0,"PREDICTED: Rattus norvegicus MYCBP-associated, testis expressed 1 (Maats1), partial mRNA","Q8BRC6",1261,0,"Cilia- and flagella-associated protein 91",".",".",".",".","pfam14738","PaaSYMP","Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1. PAT1 (proton amino acid transporter 1), also known as TRAMD3 of AAT-1, is the molecular correlate of the intestinal imino acid carrier. It is a proton-amino acid co-transporter having a stoichiometry of 1:1. Due to its mechanism, PAT1 activity increases at acidic pH, which correlates well with the acidic micro-climate close to the brush-border in the intestine. Glycine, proline, and alanine are the preferred substrates of the transporter. The maximum velocity is similar for the three substrates. All substrates are transported with low affinity, showing Km values in the range of 2-10 mM. The transporter does not discriminate between L- and D-isoforms of these amino acids; in addition, beta-alanine is transported with similar affinity as alpha-alanine. Similar to the IMINO transporter, the amino acid analog MeAIB is recognized by PAT1. The transporter is strongly expressed in the small intestine, colon, kidney, and brain.",".",".",".","K25461","CFAP91, MAATS1; cilia- and flagella-associated protein 91"]
["ENSRNOG00000016837",15,1.245399908,6,0.385982629,3.226569835,1.690001251,0.010417538,0.008235759,"up","yes","Ckm","protein_coding","chr1:79061456-79071720:+","gi|6978661|ref|NP_036662.1|",1896,0,"creatine kinase M-type [Rattus norvegicus]","gi|560879438|ref|NM_012530.2|",1437,0,"Rattus norvegicus creatine kinase, M-type (Ckm), mRNA","P00564",731,0,"Creatine kinase M-type","CAC3190",73.9,{"v":1E-13,"d":"1.00E-13"},"COG3869","pfam00217","ATP-gua_Ptrans","ATP:guanido phosphotransferase, C-terminal catalytic domain. The substrate binding site is located in the cleft between N and C-terminal domains, but most of the catalytic residues are found in the larger C-terminal domain.","GO:0009408|response to heat;GO:0016310|phosphorylation;GO:0046314|phosphocreatine biosynthetic process;","GO:0005615|extracellular space;GO:0005737|cytoplasm;","GO:0004111|creatine kinase activity;GO:0005524|ATP binding;GO:0016301|kinase activity;","K00933","E2.7.3.2; creatine kinase [EC:2.7.3.2]"]
["ENSRNOG00000071200",15,1.245399908,6,0.385982629,3.226569835,1.690001251,0.010417538,0.008235759,"up","yes","RGD1559714","protein_coding","chr2:181837105-181953508:-","gi|392350953|ref|XP_003750803.1|",1874,0,"PREDICTED: TD and POZ domain-containing protein 5-like isoform X2 [Rattus norvegicus]","gi|199612194|gb|FJ004892.1|",2152,0,"Rattus norvegicus clone T1E16-A RTDPOZ-T1 mRNA, complete cds","Q717B2",472,{"v":2e-157,"d":"2.00E-157"},"TD and POZ domain-containing protein 2",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.",".",".",".",".","."]
["ENSRNOG00000003883",6,0.498159963,0,0.032165219,15.48753521,3.953035657,0.01045948,0.008257687,"up","yes","ENSRNOG00000003883","protein_coding","chrX:40605511-40606469:+","gi|114145800|ref|NP_001041359.1|",1447,0,"uncharacterized protein LOC317456 [Rattus norvegicus]","gi|114145799|ref|NM_001047894.1|",807,0,"Rattus norvegicus hypothetical LOC317456 (LOC317456), mRNA","Q91YX5",512,0,"Acyl-CoA:lysophosphatidylglycerol acyltransferase 1","SPBC428.14",57.4,9e-09,"COG0204","pfam11495","Regulator_TrmB","Archaeal transcriptional regulator TrmB. TrmB is an alpha-glucoside sensing transcriptional regulator. The protein is the transcriptional repressor for gene cluster encoding trehalose/maltose ABC transporter in T.litoralis and P.furiosus. TrmB has lost its DNA binding domain but retained its sugar recognition site. A nonreducing glucosyl residue is shared by all substrates bound to TrmB which suggests that its a common recognition motif.","GO:0008150|biological_process;GO:0036149|phosphatidylinositol acyl-chain remodeling;","GO:0005575|cellular_component;GO:0005783|endoplasmic reticulum;GO:0012505|endomembrane system;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0016746|transferase activity, transferring acyl groups;",".","."]
["ENSRNOG00000006306",6,0.498159963,0,0.032165219,15.48753521,3.953035657,0.01045948,0.008257687,"up","yes","Gip","protein_coding","chr10:80968352-80976503:+","gi|564373913|ref|XP_006247239.1|",716,{"v":1e-92,"d":"1.00E-92"},"PREDICTED: gastric inhibitory polypeptide isoform X2 [Rattus norvegicus]","gi|56235|emb|X66724.1|",644,0,"R.norvegicus mRNA for gastric inhibitory peptide (GIP)","Q06145",266,{"v":3e-89,"d":"3.00E-89"},"Gastric inhibitory polypeptide",".",".",".",".","pfam00123","Hormone_2","Peptide hormone. This family contains glucagon, GIP, secretin and VIP.","GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007565|female pregnancy;GO:0007613|memory;GO:0008344|adult locomotory behavior;GO:0009410|response to xenobiotic stimulus;GO:0009743|response to carbohydrate;GO:0009749|response to glucose;GO:0010269|response to selenium ion;GO:0010447|response to acidic pH;GO:0010828|positive regulation of glucose transmembrane transport;GO:0014070|response to organic cyclic compound;GO:0019233|sensory perception of pain;GO:0031018|endocrine pancreas development;GO:0031667|response to nutrient levels;GO:0032024|positive regulation of insulin secretion;GO:0033993|response to lipid;GO:0035640|exploration behavior;GO:0038192|gastric inhibitory peptide signaling pathway;GO:0042304|regulation of fatty acid biosynthetic process;GO:0042594|response to starvation;GO:0043200|response to amino acid;GO:0043434|response to peptide hormone;GO:0043950|positive regulation of cAMP-mediated signaling;GO:0048678|response to axon injury;GO:0050796|regulation of insulin secretion;GO:0050806|positive regulation of synaptic transmission;GO:0055123|digestive system development;GO:0060291|long-term synaptic potentiation;GO:0070094|positive regulation of glucagon secretion;GO:0070328|triglyceride homeostasis;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0043025|neuronal cell body;","GO:0005102|signaling receptor binding;GO:0005179|hormone activity;GO:0031767|gastric inhibitory polypeptide receptor binding;GO:0031769|glucagon receptor binding;","K05258","GIP; gastric inhibitory polypeptide"]
["ENSRNOG00000011460",6,0.498159963,0,0.032165219,15.48753521,3.953035657,0.01045948,0.008257687,"up","yes","Arfgef3","protein_coding","chr1:13244830-13404084:-","gi|109460492|ref|XP_001072524.1|",10715,0,"PREDICTED: brefeldin A-inhibited guanine nucleotide-exchange protein 3 isoform X1 [Rattus norvegicus]","gi|672012479|ref|XM_001072524.5|",8054,0,"PREDICTED: Rattus norvegicus similar to mKIAA1244 protein (RGD1309903), transcript variant X1, mRNA","Q3UGY8",4004,0,"Brefeldin A-inhibited guanine nucleotide-exchange protein 3",".",".",".",".","pfam09324","DUF1981","Domain of unknown function (DUF1981). Members of this family of functionally uncharacterized domains are found in various plant and yeast protein transport proteins.","GO:0030036|actin cytoskeleton organization;GO:0032012|regulation of ARF protein signal transduction;GO:0050790|regulation of catalytic activity;",".","GO:0005085|guanyl-nucleotide exchange factor activity;","K17572","ARFGEF3, KEPI; brefeldin A-inhibited guanine nucleotide-exchange protein 3"]
["ENSRNOG00000016997",6,0.498159963,0,0.032165219,15.48753521,3.953035657,0.01045948,0.008257687,"up","yes","Bnip5","protein_coding","chr20:6956201-6975091:-","gi|672085908|ref|XP_008771013.1|",2177,0,"PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein C6orf222 homolog isoform X2 [Rattus norvegicus]","gi|146149258|ref|NM_172450.3|",1312,0,"Mus musculus RIKEN cDNA 4930539E08 gene (4930539E08Rik), mRNA",".",".",".",".",".",".",".",".","pfam04484","DUF566","Family of unknown function (DUF566). Family of related proteins that is plant specific.",".",".",".",".","."]
["ENSRNOG00000020098",6,0.498159963,0,0.032165219,15.48753521,3.953035657,0.01045948,0.008257687,"up","yes","Lypd4","protein_coding","chr1:80460487-80466011:-","gi|672035204|ref|XP_008757204.1|",1271,{"v":4e-173,"d":"4.00E-173"},"PREDICTED: ly6/PLAUR domain-containing protein 4 isoform X1 [Rattus norvegicus]","gi|160333443|ref|NM_001110295.1|",1147,0,"Rattus norvegicus Ly6/Plaur domain containing 4 (Lypd4), mRNA","Q8BVP6",442,{"v":3e-154,"d":"3.00E-154"},"Ly6/PLAUR domain-containing protein 4",".",".",".",".","pfam00021","UPAR_LY6","u-PAR/Ly-6 domain. This extracellular disulphide bond rich domain is related to pfam00087.",".","GO:0044853|plasma membrane raft;GO:0046658|anchored component of plasma membrane;",".",".","."]
["ENSRNOG00000026133",6,0.498159963,0,0.032165219,15.48753521,3.953035657,0.01045948,0.008257687,"up","yes","Ly6d","protein_coding","chr7:106643232-106644733:-","gi|194474068|ref|NP_001124024.1|",496,{"v":5e-60,"d":"5.00E-60"},"lymphocyte antigen 6D precursor [Rattus norvegicus]","gi|194474067|ref|NM_001130552.1|",719,0,"Rattus norvegicus lymphocyte antigen 6 complex, locus D (Ly6d), mRNA","P35459",130,{"v":3e-36,"d":"3.00E-36"},"Lymphocyte antigen 6D",".",".",".",".","pfam00021","UPAR_LY6","u-PAR/Ly-6 domain. This extracellular disulphide bond rich domain is related to pfam00087.","GO:0030098|lymphocyte differentiation;GO:0035634|response to stilbenoid;","GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0031225|anchored component of membrane;",".","K06846","LY6D_E_F_G6_H; lymphocyte antigen 6 complex locus protein D/E/F/G6/H"]
["ENSRNOG00000060673",6,0.498159963,0,0.032165219,15.48753521,3.953035657,0.01045948,0.008257687,"up","yes","AC135757.1","snoRNA","chr14:95388530-95388662:-",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","pfam02437","Ski_Sno","SKI/SNO/DAC family. This family contains a presumed domain that is about 100 amino acids long. All members of this family contain a conserved CLPQ motif. The c-ski proto-oncogene has been shown to influence proliferation, morphological transformation and myogenic differentiation. Sno, a Ski proto-oncogene homologue, is expressed in two isoforms and plays a role in the response to proliferation stimuli. Dachshund also contains this domain. It is involved in various aspects of development.",".",".",".",".","."]
["ENSRNOG00000063895",6,0.498159963,0,0.032165219,15.48753521,3.953035657,0.01045948,0.008257687,"up","yes","ENSRNOG00000063895","lncRNA","chr14:104865618-104870059:+",".",".",".",".","gi|77157707|gb|AC159092.11|",580,0,"Mus musculus chromosome 1, clone RP23-103C13, complete sequence",".",".",".",".",".",".",".",".","pfam15188","CCDC-167","Coiled-coil domain-containing protein 167. The function of this family of coiled-coil domains, has not, as yet, been determined. Members of this family remain uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between and 103 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000063986",6,0.498159963,0,0.032165219,15.48753521,3.953035657,0.01045948,0.008257687,"up","yes","ENSRNOG00000063986","protein_coding","chr1:28884390-28908949:+","gi|672012590|ref|XP_008772530.1|",1935,0,"PREDICTED: zinc finger protein 420-like isoform X2 [Rattus norvegicus]","gi|672012589|ref|XM_008774308.1|",1462,0,"PREDICTED: Rattus norvegicus zinc finger protein 420-like (LOC100911237), transcript variant X3, mRNA","Q14585",476,{"v":2e-161,"d":"2.00E-161"},"Zinc finger protein 345",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.",".",".",".",".","."]
["ENSRNOG00000065364",6,0.498159963,0,0.032165219,15.48753521,3.953035657,0.01045948,0.008257687,"up","yes","ENSRNOG00000065364","lncRNA","chr20:3462777-3465286:-",".",".",".",".","gi|110350025|gb|AC130591.5|",1031,0,"Rattus norvegicus BAC CH230-312A21 () complete sequence",".",".",".",".",".",".",".",".","pfam14996","RMP","Retinal Maintenance. RMP is encoded for by a gene, C8orf37. Mutations in the gene cause two types of retinal dystrophies: cone-rod dystrophy type 16 (CORD16) and retinitis pigmentosa type 64 (RP64). CORD16 affects the cone receptors which detect red, green or blue wavelengths of light and RP64 affects the cone receptors first and then the rod receptors. Both of these affect the photo-receptors in the eye leading to colour blindness or blindness respectively.",".",".",".",".","."]
["ENSRNOG00000002024",7,0.581186624,1,0.064330438,9.034395538,3.175428078,0.011026861,0.008656463,"up","yes","Epha5","protein_coding","chr14:23653393-24017317:+","gi|672075835|ref|XP_008768281.1|",5293,0,"PREDICTED: ephrin type-A receptor 5 isoform X1 [Rattus norvegicus]","gi|672075834|ref|XM_008770059.1|",4882,0,"PREDICTED: Rattus norvegicus EPH receptor A5 (Epha5), transcript variant X1, mRNA","P54756",1984,0,"Ephrin type-A receptor 5",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0007162|negative regulation of cell adhesion;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007275|multicellular organism development;GO:0007411|axon guidance;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0019933|cAMP-mediated signaling;GO:0021766|hippocampus development;GO:0032793|positive regulation of CREB transcription factor activity;GO:0032956|regulation of actin cytoskeleton organization;GO:0033674|positive regulation of kinase activity;GO:0043087|regulation of GTPase activity;GO:0048013|ephrin receptor signaling pathway;GO:0048666|neuron development;GO:0060997|dendritic spine morphogenesis;GO:0061178|regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:1904322|cellular response to forskolin;","GO:0005791|rough endoplasmic reticulum;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005912|adherens junction;GO:0009897|external side of plasma membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043235|receptor complex;GO:0048471|perinuclear region of cytoplasm;GO:0071944|cell periphery;","GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0005003|ephrin receptor activity;GO:0005004|GPI-linked ephrin receptor activity;GO:0005005|transmembrane-ephrin receptor activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0019838|growth factor binding;","K05106","EPHA5, EHK1, TYRO4; Eph receptor A5 [EC:2.7.10.1]"]
["ENSRNOG00000006831",7,0.581186624,1,0.064330438,9.034395538,3.175428078,0.011026861,0.008656463,"up","yes","Pgr","protein_coding","chr8:6072673-6131344:+","gi|149020703|gb|EDL78508.1|",4239,0,"rCG31710 [Rattus norvegicus]","gi|305419377|gb|HM037361.1|",3399,0,"Rattus norvegicus strain BN progesterone receptor (Pgr) mRNA, complete cds","Q63449",1612,0,"Progesterone receptor",".",".",".",".","pfam02161","Prog_receptor","Progesterone receptor.","GO:0001542|ovulation from ovarian follicle;GO:0001553|luteinization;GO:0002070|epithelial cell maturation;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008284|positive regulation of cell proliferation;GO:0010629|negative regulation of gene expression;GO:0014911|positive regulation of smooth muscle cell migration;GO:0016101|diterpenoid metabolic process;GO:0030518|intracellular steroid hormone receptor signaling pathway;GO:0030879|mammary gland development;GO:0032570|response to progesterone;GO:0038001|paracrine signaling;GO:0042220|response to cocaine;GO:0043066|negative regulation of apoptotic process;GO:0043627|response to estrogen;GO:0044849|estrous cycle;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048286|lung alveolus development;GO:0050678|regulation of epithelial cell proliferation;GO:0050847|progesterone receptor signaling pathway;GO:0060085|smooth muscle relaxation of the bladder outlet;GO:0060180|female mating behavior;GO:0060748|tertiary branching involved in mammary gland duct morphogenesis;GO:0071371|cellular response to gonadotropin stimulus;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0071373|cellular response to luteinizing hormone stimulus;GO:1904709|negative regulation of granulosa cell apoptotic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0043005|neuron projection;GO:0043197|dendritic spine;GO:0043204|perikaryon;GO:0043679|axon terminus;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001223|transcription coactivator binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003707|steroid hormone receptor activity;GO:0004879|nuclear receptor activity;GO:0005102|signaling receptor binding;GO:0005496|steroid binding;GO:0005515|protein binding;GO:0008270|zinc ion binding;GO:0019899|enzyme binding;GO:0042562|hormone binding;GO:0042802|identical protein binding;GO:0043565|sequence-specific DNA binding;GO:0051117|ATPase binding;","K08556","PGR, NR3C3; progesterone receptor"]
["ENSRNOG00000008439",7,0.581186624,1,0.064330438,9.034395538,3.175428078,0.011026861,0.008656463,"up","yes","Gprc5d","protein_coding","chr4:167943523-167955616:-","gi|157823819|ref|NP_001102724.1|",1460,0,"G-protein coupled receptor family C group 5 member D [Rattus norvegicus]","gi|157823818|ref|NM_001109254.1|",1402,0,"Rattus norvegicus G protein-coupled receptor, class C, group 5, member D (Gprc5d), mRNA","Q9JIL6",565,0,"G-protein coupled receptor family C group 5 member D",".",".",".",".","pfam00003","7tm_3","7 transmembrane sweet-taste receptor of 3 GCPR. This is a domain of seven transmembrane regions that forms the C-terminus of some subclass 3 G-coupled-protein receptors. It is often associated with a downstream cysteine-rich linker domain, NCD3G pfam07562, which is the human sweet-taste receptor, and the N-terminal domain, ANF_receptor pfam01094. The seven TM regions assemble in such a way as to produce a docking pocket into which such molecules as cyclamate and lactisole have been found to bind and consequently confer the taste of sweetness.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0032147|activation of protein kinase activity;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0043235|receptor complex;GO:0070062|extracellular exosome;","GO:0004930|G protein-coupled receptor activity;GO:0030295|protein kinase activator activity;","K04621","GPRC5D; G protein-coupled receptor family C group 5 member D"]
["ENSRNOG00000008902",7,0.581186624,1,0.064330438,9.034395538,3.175428078,0.011026861,0.008656463,"up","yes","Pon1","protein_coding","chr4:33294722-33321360:-","gi|54292130|ref|NP_114466.1|",1299,{"v":4e-173,"d":"4.00E-173"},"serum paraoxonase/arylesterase 1 precursor [Rattus norvegicus]","gi|298882656|emb|FQ211041.1|",846,0,"Rattus norvegicus TL0ABA18YH09 mRNA sequence","P55159",504,{"v":1E-174,"d":"1.00E-174"},"Serum paraoxonase/arylesterase 1",".",".",".",".","pfam01731","Arylesterase","Arylesterase. This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1.2. These enzymes hydrolyse organophosphorus esters such as paraoxon and are found in the liver and blood. They confer resistance to organophosphate toxicity. Human arylesterase (PON1) is associated with HDL and may protect against LDL oxidation.","GO:0006629|lipid metabolic process;GO:0008203|cholesterol metabolic process;GO:0009636|response to toxic substance;GO:0010875|positive regulation of cholesterol efflux;GO:0016311|dephosphorylation;GO:0019439|aromatic compound catabolic process;GO:0031667|response to nutrient levels;GO:0032411|positive regulation of transporter activity;GO:0046395|carboxylic acid catabolic process;GO:0046434|organophosphate catabolic process;GO:0046470|phosphatidylcholine metabolic process;GO:0051099|positive regulation of binding;GO:0070542|response to fatty acid;GO:1902617|response to fluoride;","GO:0005615|extracellular space;GO:0034364|high-density lipoprotein particle;GO:0034366|spherical high-density lipoprotein particle;GO:0043231|intracellular membrane-bounded organelle;","GO:0004063|aryldialkylphosphatase activity;GO:0004064|arylesterase activity;GO:0005509|calcium ion binding;GO:0005543|phospholipid binding;GO:0042803|protein homodimerization activity;GO:0102007|acyl-L-homoserine-lactone lactonohydrolase activity;","K01045","PON; arylesterase / paraoxonase [EC:3.1.1.2 3.1.8.1]"]
["ENSRNOG00000009181",7,0.581186624,1,0.064330438,9.034395538,3.175428078,0.011026861,0.008656463,"up","yes","Dleu7","protein_coding","chr15:36479534-36495697:-","gi|157823151|ref|NP_001099513.1|",781,{"v":3e-97,"d":"3.00E-97"},"leukemia-associated protein 7 [Rattus norvegicus]","gi|157823150|ref|NM_001106043.1|",1693,0,"Rattus norvegicus deleted in lymphocytic leukemia, 7 (Dleu7), mRNA",".",".",".",".",".",".",".",".","pfam11951","Fungal_trans_2","Fungal specific transcription factor domain. This family of are likely to be transcription factors. This protein is found in fungi. Proteins in this family are typically between 454 to 826 amino acids in length. This protein is found associated with pfam00172.",".",".",".",".","."]
["ENSRNOG00000010349",7,0.581186624,1,0.064330438,9.034395538,3.175428078,0.011026861,0.008656463,"up","yes","Ghrl","protein_coding","chr4:146865712-146869621:-","gi|755517129|ref|XP_011239724.1|",498,{"v":2e-59,"d":"2.00E-59"},"PREDICTED: appetite-regulating hormone isoform X2 [Mus musculus]","gi|291463294|ref|NM_021669.2|",500,0,"Rattus norvegicus ghrelin/obestatin prepropeptide (Ghrl), mRNA","Q9QYH7",186,{"v":6e-59,"d":"6.00E-59"},"Appetite-regulating hormone",".",".",".",".","pfam04643","Motilin_assoc","Motilin/ghrelin-associated peptide. This family represents a peptide sequence that lies C-terminal to motilin/ghrelin on the respective precursor peptide. Its function is unknown.","GO:0001696|gastric acid secretion;GO:0001937|negative regulation of endothelial cell proliferation;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0008154|actin polymerization or depolymerization;GO:0008343|adult feeding behavior;GO:0009725|response to hormone;GO:0016358|dendrite development;GO:0031667|response to nutrient levels;GO:0032024|positive regulation of insulin secretion;GO:0032095|regulation of response to food;GO:0032097|positive regulation of response to food;GO:0032100|positive regulation of appetite;GO:0032691|negative regulation of interleukin-1 beta production;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0035483|gastric emptying;GO:0035774|positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0040010|positive regulation of growth rate;GO:0040013|negative regulation of locomotion;GO:0042127|regulation of cell proliferation;GO:0042322|negative regulation of circadian sleep/wake cycle, REM sleep;GO:0043066|negative regulation of apoptotic process;GO:0043410|positive regulation of MAPK cascade;GO:0043627|response to estrogen;GO:0045927|positive regulation of growth;GO:0046010|positive regulation of circadian sleep/wake cycle, non-REM sleep;GO:0046676|negative regulation of insulin secretion;GO:0046697|decidualization;GO:0050728|negative regulation of inflammatory response;GO:0051461|positive regulation of corticotropin secretion;GO:0051464|positive regulation of cortisol secretion;GO:0051602|response to electrical stimulus;GO:0051965|positive regulation of synapse assembly;GO:0051969|regulation of transmission of nerve impulse;GO:0060079|excitatory postsynaptic potential;GO:0060124|positive regulation of growth hormone secretion;GO:0061098|positive regulation of protein tyrosine kinase activity;GO:0097009|energy homeostasis;GO:0099170|postsynaptic modulation of chemical synaptic transmission;GO:0099175|regulation of postsynapse organization;GO:0120058|positive regulation of small intestinal transit;GO:0120162|positive regulation of cold-induced thermogenesis;GO:1903012|positive regulation of bone development;GO:1903672|positive regulation of sprouting angiogenesis;GO:1904000|positive regulation of eating behavior;GO:1904179|positive regulation of adipose tissue development;GO:1904306|positive regulation of gastro-intestinal system smooth muscle contraction;GO:1904346|positive regulation of gastric mucosal blood circulation;GO:1904349|positive regulation of small intestine smooth muscle contraction;GO:1905333|regulation of gastric motility;GO:1905564|positive regulation of vascular endothelial cell proliferation;GO:2000253|positive regulation of feeding behavior;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0030424|axon;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098794|postsynapse;GO:0098978|glutamatergic synapse;","GO:0001664|G protein-coupled receptor binding;GO:0005179|hormone activity;GO:0016608|growth hormone-releasing hormone activity;GO:0030296|protein tyrosine kinase activator activity;GO:0031768|ghrelin receptor binding;","K05254","GHRL; ghrelin"]
["ENSRNOG00000028926",7,0.581186624,1,0.064330438,9.034395538,3.175428078,0.011026861,0.008656463,"up","yes","ENSRNOG00000028926","protein_coding","chr10:14347327-14350598:+","gi|672024613|ref|XP_008772926.1|",1242,{"v":9E-170,"d":"9.00E-170"},"PREDICTED: LOW QUALITY PROTEIN: serine protease 29 [Rattus norvegicus]","gi|672024612|ref|XM_008774704.1|",709,0,"PREDICTED: Rattus norvegicus similar to implantation serine proteinase 2 (RGD1559662), mRNA","Q99MS4",357,{"v":6e-122,"d":"6.00E-122"},"Serine protease 29","VC1649",108,{"v":8e-26,"d":"8.00E-26"},"COG5640","pfam00089","Trypsin","Trypsin.",".",".",".",".","."]
["ENSRNOG00000029128",7,0.581186624,1,0.064330438,9.034395538,3.175428078,0.011026861,0.008656463,"up","yes","Cyp2d5","protein_coding","chr7:113899890-113904495:-","gi|56972326|gb|AAH88097.1|",2041,0,"Cytochrome P450, family 2, subfamily d, polypeptide 5 [Rattus norvegicus]","gi|203775|gb|M25143.1|RATCYP45J",1225,0,"Rat cytochrome P450CMF1b mRNA, complete cds","P12939",783,0,"Cytochrome P450 2D10",".",".",".",".","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0006082|organic acid metabolic process;GO:0006805|xenobiotic metabolic process;GO:0019369|arachidonic acid metabolic process;GO:0042178|xenobiotic catabolic process;","GO:0005737|cytoplasm;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0004497|monooxygenase activity;GO:0005506|iron ion binding;GO:0008395|steroid hydroxylase activity;GO:0016712|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0020037|heme binding;GO:0070330|aromatase activity;","K07414","CYP2D; cytochrome P450 family 2 subfamily D [EC:1.14.14.1]"]
["ENSRNOG00000036834",7,0.581186624,1,0.064330438,9.034395538,3.175428078,0.011026861,0.008656463,"up","yes","Gpr84","protein_coding","chr7:134443936-134446178:-","gi|157824113|ref|NP_001102979.1|",1870,0,"G-protein coupled receptor 84 [Rattus norvegicus]","gi|672060304|ref|XM_006242448.2|",1509,0,"PREDICTED: Rattus norvegicus G protein-coupled receptor 84 (Gpr84), transcript variant X1, mRNA","Q8CIM5",687,0,"G-protein coupled receptor 84",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007218|neuropeptide signaling pathway;","GO:0005887|integral component of plasma membrane;GO:0043235|receptor complex;","GO:0001604|urotensin II receptor activity;GO:0008528|G protein-coupled peptide receptor activity;","K08421","GPR84; G protein-coupled receptor 84"]
["ENSRNOG00000056141",7,0.581186624,1,0.064330438,9.034395538,3.175428078,0.011026861,0.008656463,"up","yes","Matn3","protein_coding","chr6:31748474-31768101:+","gi|157819693|ref|NP_001101483.1|",2301,0,"matrilin-3 precursor [Rattus norvegicus]","gi|157819692|ref|NM_001108013.1|",1999,0,"Rattus norvegicus matrilin 3 (Matn3), mRNA","O35701",853,0,"Matrilin-3",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0008150|biological_process;GO:0051216|cartilage development;","GO:0005575|cellular_component;GO:0031012|extracellular matrix;GO:0062023|collagen-containing extracellular matrix;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;","K19467","MATN; matrilin"]
["ENSRNOG00000058218",7,0.581186624,1,0.064330438,9.034395538,3.175428078,0.011026861,0.008656463,"up","yes","AC131806.3","protein_coding","chr19:21675357-21675977:-","gi|817252388|ref|XP_012314305.1|",698,{"v":1E-91,"d":"1.00E-91"},"PREDICTED: 40S ribosomal protein S11-like [Aotus nancymaae]","gi|298910261|emb|FQ222285.1|",366,0,"Rattus norvegicus TL0ADA25YJ14 mRNA sequence","P62282",269,{"v":1E-91,"d":"1.00E-91"},"40S ribosomal protein S11","YDR025w",181,{"v":2e-57,"d":"2.00E-57"},"COG0186","pfam00366","Ribosomal_S17","Ribosomal protein S17.",".",".",".",".","."]
["ENSRNOG00000067260",7,0.581186624,1,0.064330438,9.034395538,3.175428078,0.011026861,0.008656463,"up","yes","ENSRNOG00000067260","lncRNA","chr4:151061589-151065913:+",".",".",".",".","gi|61675712|gb|AC153918.4|",420,0,"Mus musculus BAC RP23-89M16 (Roswell Park Cancer Institute (C57BL/6J Female) Mouse BAC Library) complete sequence",".",".",".",".",".",".",".",".","pfam10034","Dpy19","Q-cell neuroblast polarisation. Dyp-19, formerly known as DUF2211, is a transmembrane domain family that is required to orient the neuroblast cells, QR and QL accurately on the anterior-posterior axis: QL and QR are born in the same anterior-posterior position, but polarise and migrate left-right asymmetrically, QL migrating towards the posterior and QR migrating towards the anterior. It is also required, with unc-40, to express mab-5 correctly in the Q cell descendants. The Dpy-19 protein derives from the C. elegans DUMPY mutant.",".",".",".",".","."]
["ENSRNOG00000067771",7,0.581186624,1,0.064330438,9.034395538,3.175428078,0.011026861,0.008656463,"up","yes","ENSRNOG00000067771","protein_coding","chr4:53166319-53167227:+","gi|355701937|gb|EHH29290.1|",130,1E-8,"hypothetical protein EGK_09666 [Macaca mulatta]","gi|672049967|ref|XM_006236692.2|",118,{"v":2e-53,"d":"2.00E-53"},"PREDICTED: Rattus norvegicus thymosin, beta 10 (Tmsb10), transcript variant X1, mRNA","P63312",50.4,2E-8,"Thymosin beta-10",".",".",".",".","pfam01290","Thymosin","Thymosin beta-4 family.",".",".",".",".","."]
["ENSRNOG00000068310",7,0.581186624,1,0.064330438,9.034395538,3.175428078,0.011026861,0.008656463,"up","yes","C10H5orf58","protein_coding","chr10:18688847-18697220:-","gi|880891516|ref|XP_012970197.1|",306,{"v":1e-32,"d":"1.00E-32"},"PREDICTED: putative uncharacterized protein C5orf58 homolog [Mesocricetus auratus]","gi|589932315|ref|XR_442794.1|",175,{"v":8e-85,"d":"8.00E-85"},"PREDICTED: Peromyscus maniculatus bairdii uncharacterized LOC102918264 (LOC102918264), ncRNA",".",".",".",".",".",".",".",".","pfam04426","Bul1_C","Bul1 C terminus. This family contains the C terminus of Saccharomyces cerevisiae Bul1. Bul1 binds the ubiquitin ligase Rsp5, via an N terminal PPSY motif. The complex containing Bul1 and Rsp5 is involved in intracellular trafficking of the general amino acid permease Gap1, degradation of Rog1 in cooperation with Bul2 and GSK-3, and mitochondrial inheritance. Bul1 may contain HEAT repeats.",".",".",".",".","."]
["ENSRNOG00000069746",7,0.581186624,1,0.064330438,9.034395538,3.175428078,0.011026861,0.008656463,"up","yes","ENSRNOG00000069746","protein_coding","chr15:33488088-33505047:-","gi|62079205|ref|NP_001014257.1|",1353,0,"PHD finger protein 11-like [Rattus norvegicus]","gi|62079204|ref|NM_001014235.1|",1176,0,"Rattus norvegicus PHD finger protein 11B (Phf11b), mRNA","Q5I0J8",525,0,"PHD finger protein 11-like",".",".",".",".","pfam13771","zf-HC5HC2H","PHD-like zinc-binding domain. The members of this family are annotated as containing PHD domain, but the zinc-binding region here is not typical of PHD domains. The conformation here is a well-conserved cysteine-histidine rich region spanning 90 residues, where the Cys and His are arranged as HxxC(31)CxxC(6)CxxCxxxxCxxxxHxxC (21)CxxH.",".",".",".",".","."]
["ENSRNOG00000005650",26,2.158693174,15,0.964956573,2.237088419,1.161622279,0.011072247,0.008688021,"up","yes","Pgf","protein_coding","chr6:104816104-104826685:-","gi|16758378|ref|NP_446047.1|",851,{"v":5e-109,"d":"5.00E-109"},"placenta growth factor precursor [Rattus norvegicus]","gi|56799414|ref|NM_053595.2|",1561,0,"Rattus norvegicus placental growth factor (Pgf), mRNA","Q63434",332,{"v":2e-110,"d":"2.00E-110"},"Placenta growth factor",".",".",".",".","pfam00341","PDGF","PDGF/VEGF domain.","GO:0001658|branching involved in ureteric bud morphogenesis;GO:0001666|response to hypoxia;GO:0001934|positive regulation of protein phosphorylation;GO:0001938|positive regulation of endothelial cell proliferation;GO:0002040|sprouting angiogenesis;GO:0007565|female pregnancy;GO:0008284|positive regulation of cell proliferation;GO:0009410|response to xenobiotic stimulus;GO:0030154|cell differentiation;GO:0031100|animal organ regeneration;GO:0032870|cellular response to hormone stimulus;GO:0038084|vascular endothelial growth factor signaling pathway;GO:0045766|positive regulation of angiogenesis;GO:0048010|vascular endothelial growth factor receptor signaling pathway;GO:0050918|positive chemotaxis;GO:0050930|induction of positive chemotaxis;GO:0051781|positive regulation of cell division;GO:0060688|regulation of morphogenesis of a branching structure;GO:0060754|positive regulation of mast cell chemotaxis;","GO:0005615|extracellular space;GO:0016020|membrane;","GO:0005172|vascular endothelial growth factor receptor binding;GO:0008083|growth factor activity;GO:0042056|chemoattractant activity;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;","K16859","PGF; placenta growth factor"]
["ENSRNOG00000034237",20,1.66053321,10,0.643304382,2.581255868,1.368073156,0.01134596,0.008881886,"up","yes","Rpl39","protein_coding","chr18:6326330-6326692:-","gi|148697042|gb|EDL28989.1|",331,{"v":1e-37,"d":"1.00E-37"},"mCG146274, partial [Mus musculus]","gi|672030478|ref|XM_008774092.1|",363,0,"PREDICTED: Rattus norvegicus 60S ribosomal protein L39 (LOC103694169), mRNA","P62893",103,{"v":2e-28,"d":"2.00E-28"},"60S ribosomal protein L39","SPCC663.04",76.3,{"v":3e-18,"d":"3.00E-18"},"COG2167","pfam00832","Ribosomal_L39","Ribosomal L39 protein.",".",".",".","K02924","RP-L39e, RPL39; large subunit ribosomal protein L39e"]
["ENSRNOG00000010094",12,0.996319926,4,0.257321753,3.871883802,1.953035657,0.011411453,0.008926598,"up","yes","Kcnmb2","protein_coding","chr2:114935976-114975173:+","gi|149048639|gb|EDM01180.1|",1391,0,"potassium large conductance calcium-activated channel, subfamily M, beta member 2, isoform CRA_c [Rattus norvegicus]","gi|755502815|ref|XM_006535549.2|",1563,0,"PREDICTED: Mus musculus potassium large conductance calcium-activated channel, subfamily M, beta member 2 (Kcnmb2), transcript variant X2, mRNA","Q9CZM9",490,{"v":4e-169,"d":"4.00E-169"},"Calcium-activated potassium channel subunit beta-2",".",".",".",".","pfam03185","CaKB","Calcium-activated potassium channel, beta subunit.","GO:0001508|action potential;GO:0005513|detection of calcium ion;GO:0006813|potassium ion transport;GO:0019228|neuronal action potential;GO:0071805|potassium ion transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0008076|voltage-gated potassium channel complex;GO:0016021|integral component of membrane;","GO:0005267|potassium channel activity;GO:0015269|calcium-activated potassium channel activity;GO:0015459|potassium channel regulator activity;","K04938","KCNMB2; potassium large conductance calcium-activated channel subfamily M beta member 2"]
["ENSRNOG00000015376",12,0.996319926,4,0.257321753,3.871883802,1.953035657,0.011411453,0.008926598,"up","yes","Npas1","protein_coding","chr1:77167381-77186762:-","gi|157819069|ref|NP_001100949.1|",2206,0,"neuronal PAS domain-containing protein 1 [Rattus norvegicus]","gi|672035026|ref|XM_006228413.2|",1965,0,"PREDICTED: Rattus norvegicus neuronal PAS domain protein 1 (Npas1), transcript variant X1, mRNA","P97459",832,0,"Neuronal PAS domain-containing protein 1",".",".",".",".","pfam14598","PAS_11","PAS domain. This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001964|startle response;GO:0006357|regulation of transcription by RNA polymerase II;GO:0042711|maternal behavior;GO:0045892|negative regulation of transcription, DNA-templated;","GO:0005634|nucleus;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0046982|protein heterodimerization activity;","K09098","NPAS1_3; neuronal PAS domain-containing protein 1/3"]
["ENSRNOG00000022852",12,0.996319926,4,0.257321753,3.871883802,1.953035657,0.011411453,0.008926598,"up","yes","Snx22","protein_coding","chr8:66609970-66612850:-","gi|564364315|ref|XP_006243367.1|",930,{"v":2e-124,"d":"2.00E-124"},"PREDICTED: sorting nexin-22 isoform X2 [Rattus norvegicus]","gi|672061932|ref|XM_006243305.2|",803,0,"PREDICTED: Rattus norvegicus sorting nexin 22 (Snx22), transcript variant X2, mRNA","Q96L94",287,{"v":5e-96,"d":"5.00E-96"},"Sorting nexin-22",".",".",".",".","pfam00787","PX","PX domain. PX domains bind to phosphoinositides.",".",".","GO:1901981|phosphatidylinositol phosphate binding;","K17941","SNX22_24; sorting nexin-22/24"]
["ENSRNOG00000054962",12,0.996319926,4,0.257321753,3.871883802,1.953035657,0.011411453,0.008926598,"up","yes","Dao","protein_coding","chr12:42592343-42612741:-","gi|16758434|ref|NP_446078.1|",1864,0,"D-amino-acid oxidase [Rattus norvegicus]","gi|16758433|ref|NM_053626.1|",1646,0,"Rattus norvegicus D-amino-acid oxidase (Dao), mRNA","O35078",722,0,"D-amino-acid oxidase","ML2011",135,{"v":2e-34,"d":"2.00E-34"},"COG0665","pfam01266","DAO","FAD dependent oxidoreductase. This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.","GO:0006551|leucine metabolic process;GO:0006562|proline catabolic process;GO:0019478|D-amino acid catabolic process;GO:0036088|D-serine catabolic process;GO:0042416|dopamine biosynthetic process;GO:0055130|D-alanine catabolic process;GO:0070178|D-serine metabolic process;","GO:0005737|cytoplasm;GO:0005741|mitochondrial outer membrane;GO:0005777|peroxisome;GO:0005778|peroxisomal membrane;GO:0005829|cytosol;","GO:0003884|D-amino-acid oxidase activity;GO:0042802|identical protein binding;GO:0071949|FAD binding;","K00273","DAO, aao; D-amino-acid oxidase [EC:1.4.3.3]"]
["ENSRNOG00000001167",16,1.328426568,7,0.450313067,2.950006706,1.560718234,0.0124675,0.009660506,"up","yes","Ubash3a","protein_coding","chr20:9292139-9329224:+","gi|672085991|ref|XP_008771040.1|",3282,0,"PREDICTED: ubiquitin-associated and SH3 domain-containing protein A isoform X1 [Rattus norvegicus]","gi|672085994|ref|XM_006256215.2|",2910,0,"PREDICTED: Rattus norvegicus ubiquitin associated and SH3 domain containing, A (Ubash3a), transcript variant X3, mRNA","Q3V3E1",1184,0,"Ubiquitin-associated and SH3 domain-containing protein A",".",".",".",".","pfam00300","His_Phos_1","Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centres on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.","GO:0001817|regulation of cytokine production;GO:0050860|negative regulation of T cell receptor signaling pathway;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;",".","K18993","UBASH3, STS; ubiquitin-associated and SH3 domain-containing protein [EC:3.1.3.48]"]
["ENSRNOG00000027035",16,1.328426568,7,0.450313067,2.950006706,1.560718234,0.0124675,0.009660506,"up","yes","Sgo2","protein_coding","chr9:59548683-59573229:+","gi|403225019|ref|NP_001258120.1|",5516,0,"shugoshin-like 2 [Rattus norvegicus]","gi|672065177|ref|XM_006244988.2|",3976,0,"PREDICTED: Rattus norvegicus shugoshin-like 2 (S. pombe) (Sgol2), transcript variant X1, mRNA","Q7TSY8",1556,0,"Shugoshin 2",".",".",".",".","pfam07558","Shugoshin_N","Shugoshin N-terminal coiled-coil region. The Shugoshin protein is found to have this conserved N-terminal coiled-coil region and a highly conserved C-terminal basic region, family Shugoshin_C pfam07557. Shugoshin is a crucial target of Bub1 kinase function at kinetochores, necessary for both meiotic and mitotic localisation of shugoshin to the kinetochore. Human shugoshin is diffusible and mediates kinetochore-driven formation of kinetochore-microtubules during bipolar spindle assembly. Further, the primary role of shugoshin is to ensure bipolar attachment of kinetochores, and its role in protecting cohesion has co-developed to facilitate this process.","GO:0000070|mitotic sister chromatid segregation;GO:0007140|male meiotic nuclear division;GO:0007143|female meiotic nuclear division;GO:0008104|protein localization;GO:0010789|meiotic sister chromatid cohesion involved in meiosis I;GO:0045143|homologous chromosome segregation;GO:0051177|meiotic sister chromatid cohesion;GO:0051301|cell division;GO:0051754|meiotic sister chromatid cohesion, centromeric;GO:2000711|positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric;","GO:0000775|chromosome, centromeric region;GO:0000776|kinetochore;GO:0000779|condensed chromosome, centromeric region;GO:0005654|nucleoplasm;GO:0016604|nuclear body;GO:0030892|mitotic cohesin complex;",".","K11581","SGOL2; shugoshin-like 2"]
["ENSRNOG00000069103",16,1.328426568,7,0.450313067,2.950006706,1.560718234,0.0124675,0.009660506,"up","yes","ENSRNOG00000069103","lncRNA","chr4:182367222-182395525:+",".",".",".",".","gi|49615119|gb|AC113720.6|",169,{"v":2e-81,"d":"2.00E-81"},"Rattus norvegicus 1 BAC CH230-117B1 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam12091","DUF3567","Protein of unknown function (DUF3567). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are about 90 amino acids in length. This protein has a conserved EIVDK sequence motif.",".",".",".",".","."]
["ENSRNOG00000014127",21,1.743559871,11,0.70763482,2.463926056,1.30095896,0.012561333,0.009715552,"up","yes","Rnf151","protein_coding","chr10:13742682-13745000:-","gi|157821155|ref|NP_001100457.1|",1165,{"v":4e-157,"d":"4.00E-157"},"RING finger protein 151 [Rattus norvegicus]","gi|157821154|ref|NM_001106987.1|",1170,0,"Rattus norvegicus ring finger protein 151 (Rnf151), mRNA","Q9CQ29",399,{"v":2E-137,"d":"2.00E-137"},"RING finger protein 151",".",".",".",".","pfam13639","zf-RING_2","Ring finger domain.","GO:0016567|protein ubiquitination;","GO:0005634|nucleus;","GO:0008270|zinc ion binding;GO:0061630|ubiquitin protein ligase activity;","K24148","RNF151; RING finger protein 151"]
["ENSRNOG00000017528",21,1.743559871,11,0.70763482,2.463926056,1.30095896,0.012561333,0.009715552,"up","yes","Gpr157","protein_coding","chr5:160550713-160566432:+","gi|58865784|ref|NP_001012107.1|",1364,{"v":5e-180,"d":"5.00E-180"},"probable G-protein coupled receptor 157 [Rattus norvegicus]","gi|58865783|ref|NM_001012107.1|",2337,0,"Rattus norvegicus G protein-coupled receptor 157 (Gpr157), mRNA","Q5FVG1",530,0,"G-protein coupled receptor 157",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0007166|cell surface receptor signaling pathway;GO:0007186|G protein-coupled receptor signaling pathway;GO:0048512|circadian behavior;GO:0051482|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway;GO:0060019|radial glial cell differentiation;","GO:0016021|integral component of membrane;GO:0060170|ciliary membrane;","GO:0004930|G protein-coupled receptor activity;","K08467","GPR157; G protein-coupled receptor 157"]
["ENSRNOG00000028622",21,1.743559871,11,0.70763482,2.463926056,1.30095896,0.012561333,0.009715552,"up","yes","Pnpla1","protein_coding","chr20:6917931-6952375:+","gi|300797542|ref|NP_001178770.1|",2955,0,"patatin-like phospholipase domain-containing protein 1 [Rattus norvegicus]","gi|300797541|ref|NM_001191841.1|",1770,0,"Rattus norvegicus patatin-like phospholipase domain containing 1 (Pnpla1), mRNA","Q3V1D5",959,0,"Patatin-like phospholipase domain-containing protein 1",".",".",".",".","pfam01734","Patatin","Patatin-like phospholipase. This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein but it also has the enzymatic activity of lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have been found also in vertebrates.","GO:0019433|triglyceride catabolic process;GO:0030216|keratinocyte differentiation;GO:0046513|ceramide biosynthetic process;GO:0055088|lipid homeostasis;GO:0061436|establishment of skin barrier;","GO:0005737|cytoplasm;GO:0005811|lipid droplet;GO:0016020|membrane;","GO:0004806|triglyceride lipase activity;GO:0016747|transferase activity, transferring acyl groups other than amino-acyl groups;GO:0030280|structural constituent of epidermis;","K16813","PNPLA1; omega-hydroxyceramide transacylase [EC:2.3.1.296]"]
["ENSRNOG00000031065",21,1.743559871,11,0.70763482,2.463926056,1.30095896,0.012561333,0.009715552,"up","yes","RT1-M1-2","protein_coding","chr20:1910656-1917936:-","gi|57012410|ref|NP_001008849.1|",1659,0,"RT1 class I, locus M1, gene 2 precursor [Rattus norvegicus]","gi|672085546|ref|XM_006255884.2|",1448,0,"PREDICTED: Rattus norvegicus RT1 class I, locus M1, gene 2 (RT1-M1-2), transcript variant X1, mRNA","P30375",331,{"v":1e-106,"d":"1.00E-106"},"Class I histocompatibility antigen, Gogo-A*0101 alpha chain",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.",".",".",".","K06751","MHC1; MHC class I antigen"]
["ENSRNOG00000033064",21,1.743559871,11,0.70763482,2.463926056,1.30095896,0.012561333,0.009715552,"up","yes","Edil3","protein_coding","chr2:19890373-20405008:+","gi|392338494|ref|XP_003753552.1|",2521,0,"PREDICTED: EGF-like repeat and discoidin I-like domain-containing protein 3 [Rattus norvegicus]","gi|672015252|ref|XM_003753504.3|",4645,0,"PREDICTED: Rattus norvegicus EGF-like repeats and discoidin I-like domains 3 (Edil3), mRNA","O35474",947,0,"EGF-like repeat and discoidin I-like domain-containing protein 3",".",".",".",".","pfam00754","F5_F8_type_C","F5/8 type C domain. This domain is also known as the discoidin (DS) domain family.","GO:0007155|cell adhesion;GO:0010811|positive regulation of cell-substrate adhesion;",".","GO:0005509|calcium ion binding;","K24464","EDIL3; EGF-like repeat and discoidin I-like domain-containing protein 3"]
["ENSRNOG00000020719",30,2.490799816,19,1.222278326,2.03783358,1.027036238,0.013526266,0.010384001,"up","yes","Hrc","protein_coding","chr1:95813253-95816984:+","gi|149055945|gb|EDM07376.1|",2378,0,"histidine rich calcium binding protein, isoform CRA_b [Rattus norvegicus]","gi|298894331|emb|FQ224148.1|",2379,0,"Rattus norvegicus TL0ACA75YF06 mRNA sequence","P16230",219,{"v":1E-58,"d":"1.00E-58"},"Sarcoplasmic reticulum histidine-rich calcium-binding protein",".",".",".",".","pfam15449","Retinal","Retinal protein. This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.","GO:0002027|regulation of heart rate;GO:0008016|regulation of heart contraction;GO:0010460|positive regulation of heart rate;GO:0010880|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0033135|regulation of peptidyl-serine phosphorylation;GO:0045823|positive regulation of heart contraction;GO:0051480|regulation of cytosolic calcium ion concentration;GO:0051481|negative regulation of cytosolic calcium ion concentration;GO:0055074|calcium ion homeostasis;GO:0060314|regulation of ryanodine-sensitive calcium-release channel activity;GO:1901844|regulation of cell communication by electrical coupling involved in cardiac conduction;GO:1901899|positive regulation of relaxation of cardiac muscle;GO:1902081|negative regulation of calcium ion import into sarcoplasmic reticulum;GO:1903169|regulation of calcium ion transmembrane transport;","GO:0005575|cellular_component;GO:0030018|Z disc;GO:0033017|sarcoplasmic reticulum membrane;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;GO:0044325|ion channel binding;GO:0051117|ATPase binding;","K23450","HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein"]
["ENSRNOG00000050413",22,1.826586532,12,0.771965258,2.366151212,1.242542274,0.013708279,0.010506072,"up","yes","Samd15","protein_coding","chr6:106840781-106860423:+","gi|564356803|ref|XP_006240460.1|",2590,0,"PREDICTED: sterile alpha motif domain-containing protein 15 isoform X1 [Rattus norvegicus]","gi|672056781|ref|XM_006240398.2|",2030,0,"PREDICTED: Rattus norvegicus sterile alpha motif domain containing 15 (Samd15), transcript variant X1, mRNA","F6XZJ7",562,0,"Sterile alpha motif domain-containing protein 15",".",".",".",".","pfam00536","SAM_1","SAM domain (Sterile alpha motif). It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.",".",".",".",".","."]
["ENSRNOG00000005133",31,2.573826476,20,1.286608764,2.000473298,1.000341372,0.014029282,0.010727659,"up","yes","Mapt","protein_coding","chr10:89138627-89236129:+","gi|672069483|ref|XP_008766494.1|",2529,0,"PREDICTED: microtubule-associated protein tau isoform X5 [Rattus norvegicus]","gi|672069482|ref|XM_008768272.1|",5655,0,"PREDICTED: Rattus norvegicus microtubule-associated protein tau (Mapt), transcript variant X5, mRNA","P19332",524,{"v":1e-162,"d":"1.00E-162"},"Microtubule-associated protein tau",".",".",".",".","pfam00418","Tubulin-binding","Tau and MAP protein, tubulin-binding repeat. This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.","GO:0000226|microtubule cytoskeleton organization;GO:0001764|neuron migration;GO:0006915|apoptotic process;GO:0007017|microtubule-based process;GO:0007409|axonogenesis;GO:0007416|synapse assembly;GO:0007420|brain development;GO:0007565|female pregnancy;GO:0007584|response to nutrient;GO:0007611|learning or memory;GO:0007613|memory;GO:0007628|adult walking behavior;GO:0008088|axo-dendritic transport;GO:0008631|intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0010033|response to organic substance;GO:0010288|response to lead ion;GO:0010506|regulation of autophagy;GO:0010629|negative regulation of gene expression;GO:0010917|negative regulation of mitochondrial membrane potential;GO:0010976|positive regulation of neuron projection development;GO:0030182|neuron differentiation;GO:0031110|regulation of microtubule polymerization or depolymerization;GO:0031116|positive regulation of microtubule polymerization;GO:0031175|neuron projection development;GO:0032387|negative regulation of intracellular transport;GO:0032930|positive regulation of superoxide anion generation;GO:0033673|negative regulation of kinase activity;GO:0045773|positive regulation of axon extension;GO:0046785|microtubule polymerization;GO:0047497|mitochondrion transport along microtubule;GO:0048312|intracellular distribution of mitochondria;GO:0048675|axon extension;GO:0050808|synapse organization;GO:0050848|regulation of calcium-mediated signaling;GO:0051028|mRNA transport;GO:0051258|protein polymerization;GO:0051260|protein homooligomerization;GO:0060632|regulation of microtubule-based movement;GO:0070507|regulation of microtubule cytoskeleton organization;GO:0090258|negative regulation of mitochondrial fission;GO:0097435|supramolecular fiber organization;GO:1900034|regulation of cellular response to heat;GO:1900454|positive regulation of long-term synaptic depression;GO:1901216|positive regulation of neuron death;GO:1902474|positive regulation of protein localization to synapse;GO:1903748|negative regulation of establishment of protein localization to mitochondrion;GO:1903829|positive regulation of cellular protein localization;GO:1904428|negative regulation of tubulin deacetylation;GO:1990000|amyloid fibril formation;GO:2001020|regulation of response to DNA damage stimulus;","GO:0005576|extracellular region;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005874|microtubule;GO:0005886|plasma membrane;GO:0005930|axoneme;GO:0009898|cytoplasmic side of plasma membrane;GO:0014069|postsynaptic density;GO:0015630|microtubule cytoskeleton;GO:0016020|membrane;GO:0016607|nuclear speck;GO:0030424|axon;GO:0030425|dendrite;GO:0030426|growth cone;GO:0030673|axolemma;GO:0034399|nuclear periphery;GO:0036464|cytoplasmic ribonucleoprotein granule;GO:0036477|somatodendritic compartment;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0044295|axonal growth cone;GO:0044297|cell body;GO:0044304|main axon;GO:0045121|membrane raft;GO:0045298|tubulin complex;GO:0097386|glial cell projection;GO:0097418|neurofibrillary tangle;","GO:0003677|DNA binding;GO:0005515|protein binding;GO:0008017|microtubule binding;GO:0017124|SH3 domain binding;GO:0019899|enzyme binding;GO:0019901|protein kinase binding;GO:0031072|heat shock protein binding;GO:0034185|apolipoprotein binding;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;GO:0051087|chaperone binding;GO:0051721|protein phosphatase 2A binding;GO:0051879|Hsp90 protein binding;GO:0071813|lipoprotein particle binding;GO:0099609|microtubule lateral binding;","K04380","MAPT, TAU; microtubule-associated protein tau"]
["ENSRNOG00000006204",17,1.411453229,8,0.514643505,2.74258436,1.455535997,0.014439711,0.011011212,"up","yes","Slc30a3","protein_coding","chr6:25275528-25284720:+","gi|672055542|ref|XP_008762747.1|",1991,0,"PREDICTED: zinc transporter 3 isoform X1 [Rattus norvegicus]","gi|672055541|ref|XM_008764525.1|",1504,0,"PREDICTED: Rattus norvegicus solute carrier family 30 (zinc transporter), member 3 (Slc30a3), transcript variant X1, mRNA","Q6QIX3",713,0,"Zinc transporter 3","ECU11g1510",156,{"v":1E-41,"d":"1.00E-41"},"COG1230","pfam01545","Cation_efflux","Cation efflux family. Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells.","GO:0010043|response to zinc ion;GO:0051050|positive regulation of transport;GO:0061088|regulation of sequestering of zinc ion;GO:0071577|zinc ion transmembrane transport;GO:0099180|zinc ion import into synaptic vesicle;","GO:0005737|cytoplasm;GO:0005765|lysosomal membrane;GO:0005770|late endosome;GO:0005886|plasma membrane;GO:0008021|synaptic vesicle;GO:0030285|integral component of synaptic vesicle membrane;GO:0030672|synaptic vesicle membrane;GO:0031902|late endosome membrane;GO:0043005|neuron projection;GO:0097457|hippocampal mossy fiber;GO:0098686|hippocampal mossy fiber to CA3 synapse;GO:0098978|glutamatergic synapse;","GO:0005385|zinc ion transmembrane transporter activity;","K14690","SLC30A3, ZNT3; solute carrier family 30 (zinc transporter), member 3"]
["ENSRNOG00000000510",13,1.079346587,5,0.321652191,3.355632628,1.746584779,0.014664253,0.011154503,"up","yes","Clps","protein_coding","chr20:6620529-6622689:-","gi|672085600|ref|XP_008770933.1|",507,{"v":4e-63,"d":"4.00E-63"},"PREDICTED: colipase isoform X1 [Rattus norvegicus]","gi|672085599|ref|XM_008772711.1|",462,0,"PREDICTED: Rattus norvegicus colipase, pancreatic (Clps), transcript variant X1, mRNA","P17084",199,{"v":2e-64,"d":"2.00E-64"},"Colipase",".",".",".",".","pfam02740","Colipase_C","Colipase, C-terminal domain. SCOP reports duplication of common fold with Colipase N-terminal domain.","GO:0007586|digestion;GO:0009617|response to bacterium;GO:0009791|post-embryonic development;GO:0016042|lipid catabolic process;GO:0032094|response to food;GO:0043085|positive regulation of catalytic activity;GO:0050790|regulation of catalytic activity;","GO:0005576|extracellular region;","GO:0008047|enzyme activator activity;","K14460","CLPS; colipase"]
["ENSRNOG00000019207",13,1.079346587,5,0.321652191,3.355632628,1.746584779,0.014664253,0.011154503,"up","yes","Shank1","protein_coding","chr1:94808276-94855824:+","gi|77627981|ref|NP_113939.2|",6691,0,"SH3 and multiple ankyrin repeat domains protein 1 [Rattus norvegicus]","gi|77627980|ref|NM_031751.2|",7556,0,"Rattus norvegicus SH3 and multiple ankyrin repeat domains 1 (Shank1), mRNA","Q9WV48",2581,0,"SH3 and multiple ankyrin repeat domains protein 1","all2748",77,{"v":3e-13,"d":"3.00E-13"},"COG0666","pfam00536","SAM_1","SAM domain (Sterile alpha motif). It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.","GO:0007616|long-term memory;GO:0008306|associative learning;GO:0030534|adult behavior;GO:0032232|negative regulation of actin filament bundle assembly;GO:0035176|social behavior;GO:0035418|protein localization to synapse;GO:0042048|olfactory behavior;GO:0046959|habituation;GO:0050885|neuromuscular process controlling balance;GO:0050894|determination of affect;GO:0060013|righting reflex;GO:0060074|synapse maturation;GO:0060997|dendritic spine morphogenesis;GO:0060999|positive regulation of dendritic spine development;GO:0065003|protein-containing complex assembly;GO:0071625|vocalization behavior;GO:0099173|postsynapse organization;GO:2000311|regulation of AMPA receptor activity;GO:2000463|positive regulation of excitatory postsynaptic potential;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0030425|dendrite;GO:0043005|neuron projection;GO:0043197|dendritic spine;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0060076|excitatory synapse;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098978|glutamatergic synapse;","GO:0005515|protein binding;GO:0008022|protein C-terminus binding;GO:0017124|SH3 domain binding;GO:0030159|receptor signaling complex scaffold activity;GO:0030160|GKAP/Homer scaffold activity;GO:0031877|somatostatin receptor binding;GO:0035255|ionotropic glutamate receptor binding;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;GO:0071532|ankyrin repeat binding;GO:0097110|scaffold protein binding;","K15009","SHANK; SH3 and multiple ankyrin repeat domains protein"]
["ENSRNOG00000036864",13,1.079346587,5,0.321652191,3.355632628,1.746584779,0.014664253,0.011154503,"up","yes","Actl10","protein_coding","chr3:143057402-143058442:+","gi|392339625|ref|XP_003753861.1|",1766,0,"PREDICTED: actin-like protein 10 [Rattus norvegicus]","gi|672017606|ref|XM_003753813.3|",1041,0,"PREDICTED: Rattus norvegicus actin-like 10 (Actl10), mRNA",".",".",".",".","YFL039c",228,{"v":7e-70,"d":"7.00E-70"},"COG5277","pfam00022","Actin","Actin.",".","GO:0005869|dynactin complex;",".",".","."]
["ENSRNOG00000055673",13,1.079346587,5,0.321652191,3.355632628,1.746584779,0.014664253,0.011154503,"up","yes","Gpr52","protein_coding","chr13:72800127-72806180:-","gi|584277097|ref|NP_001276864.1|",1826,0,"probable G-protein coupled receptor 52 [Rattus norvegicus]","gi|584277096|ref|NM_001289935.1|",3546,0,"Rattus norvegicus G protein-coupled receptor 52 (Gpr52), mRNA","P0C5J4",701,0,"G-protein coupled receptor 52",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007626|locomotory behavior;GO:0009410|response to xenobiotic stimulus;",".","GO:0004930|G protein-coupled receptor activity;","K08407","GPR52; G protein-coupled receptor 52"]
["ENSRNOG00000068089",13,1.079346587,5,0.321652191,3.355632628,1.746584779,0.014664253,0.011154503,"up","yes","ENSRNOG00000068089","lncRNA","chr9:4754863-4772982:-",".",".",".",".","gi|68159090|gb|AC154796.2|",3634,0,"Mus musculus BAC clone RP24-490B17 from chromosome 17, complete sequence",".",".",".",".",".",".",".",".","pfam08449","UAA","UAA transporter family. This family includes transporters with a specificity for UDP-N-acetylglucosamine.",".",".",".",".","."]
["ENSRNOG00000010128",23,1.909613192,13,0.836295696,2.283418652,1.191195394,0.014782574,0.011236485,"up","yes","Slc27a2","protein_coding","chr3:113804728-113842208:+","gi|51858584|gb|AAH81766.1|",3203,0,"Solute carrier family 27 (fatty acid transporter), member 2 [Rattus norvegicus]","gi|13929033|ref|NM_031736.1|",2925,0,"Rattus norvegicus solute carrier family 27 member 2 (Slc27a2), mRNA","P97524",1234,0,"Very long-chain acyl-CoA synthetase",".",".",".",".","pfam00501","AMP-binding","AMP-binding enzyme.","GO:0000038|very long-chain fatty acid metabolic process;GO:0001561|fatty acid alpha-oxidation;GO:0001676|long-chain fatty acid metabolic process;GO:0006635|fatty acid beta-oxidation;GO:0006699|bile acid biosynthetic process;GO:0015908|fatty acid transport;GO:0042760|very long-chain fatty acid catabolic process;GO:0044539|long-chain fatty acid import;GO:0097089|methyl-branched fatty acid metabolic process;","GO:0005777|peroxisome;GO:0005778|peroxisomal membrane;GO:0005779|integral component of peroxisomal membrane;GO:0005783|endoplasmic reticulum;GO:0005788|endoplasmic reticulum lumen;GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030176|integral component of endoplasmic reticulum membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0004467|long-chain fatty acid-CoA ligase activity;GO:0005324|long-chain fatty acid transporter activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0015245|fatty acid transmembrane transporter activity;GO:0019899|enzyme binding;GO:0031957|very long-chain fatty acid-CoA ligase activity;GO:0047676|arachidonate-CoA ligase activity;GO:0047747|cholate-CoA ligase activity;GO:0050197|phytanate-CoA ligase activity;GO:0070251|pristanate-CoA ligase activity;","K08746","SLC27A2, FACVL1, FATP2; solute carrier family 27 (fatty acid transporter), member 2 [EC:6.2.1.- 6.2.1.3]"]
["ENSRNOG00000039001",23,1.909613192,13,0.836295696,2.283418652,1.191195394,0.014782574,0.011236485,"up","yes","Agrp","protein_coding","chr19:33447992-33449584:-","gi|274320159|ref|NP_387499.1|",581,{"v":4E-73,"d":"4.00E-73"},"agouti-related protein precursor [Rattus norvegicus]","gi|274320158|ref|NM_033650.1|",648,0,"Rattus norvegicus agouti related neuropeptide (Agrp), mRNA","P56473",197,{"v":1E-62,"d":"1.00E-62"},"Agouti-related protein",".",".",".",".","pfam05039","Agouti","Agouti protein. The agouti protein regulates pigmentation in the mouse hair follicle producing a black hair with a subapical yellow band. A highly homologous protein agouti signal protein (ASIP)is present in humans and is expressed at highest levels in adipose tissue where it may play a role in energy homeostasis and possibly human pigmentation.","GO:0007218|neuropeptide signaling pathway;GO:0007623|circadian rhythm;GO:0007631|feeding behavior;GO:0008343|adult feeding behavior;GO:0009755|hormone-mediated signaling pathway;GO:0032868|response to insulin;GO:0042755|eating behavior;GO:0048571|long-day photoperiodism;GO:0060135|maternal process involved in female pregnancy;GO:0060259|regulation of feeding behavior;GO:2000253|positive regulation of feeding behavior;","GO:0005615|extracellular space;GO:0005796|Golgi lumen;GO:0043025|neuronal cell body;","GO:0005179|hormone activity;GO:0005184|neuropeptide hormone activity;GO:0031779|melanocortin receptor binding;GO:0070996|type 1 melanocortin receptor binding;","K05231","AGRP; agouti related protein"]
["ENSRNOG00000003284",10,0.830266605,3,0.192991315,4.302093113,2.10503875,0.015331656,0.011594583,"up","yes","Epn3","protein_coding","chr10:79438978-79447356:-","gi|564373961|ref|XP_006247263.1|",2612,0,"PREDICTED: epsin-3 isoform X2 [Rattus norvegicus]","gi|672068794|ref|XM_006247202.2|",3576,0,"PREDICTED: Rattus norvegicus epsin 3 (Epn3), transcript variant X2, mRNA","Q91W69",962,0,"Epsin-3",".",".",".",".","pfam01417","ENTH","ENTH domain. The ENTH (Epsin N-terminal homology) domain is found in proteins involved in endocytosis and cytoskeletal machinery. The function of the ENTH domain is unknown.","GO:0006897|endocytosis;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005768|endosome;GO:0005886|plasma membrane;GO:0005905|clathrin-coated pit;GO:0005938|cell cortex;GO:0019897|extrinsic component of plasma membrane;GO:0030125|clathrin vesicle coat;GO:0030136|clathrin-coated vesicle;GO:0043231|intracellular membrane-bounded organelle;GO:0048471|perinuclear region of cytoplasm;","GO:0005543|phospholipid binding;GO:0030276|clathrin binding;GO:1990175|EH domain binding;","K12471","EPN; epsin"]
["ENSRNOG00000027799",10,0.830266605,3,0.192991315,4.302093113,2.10503875,0.015331656,0.011594583,"up","yes","Tmie","protein_coding","chr8:110850034-110864803:-","gi|157817913|ref|NP_001102769.1|",499,{"v":3e-55,"d":"3.00E-55"},"transmembrane inner ear expressed protein [Rattus norvegicus]","gi|157817912|ref|NM_001109299.1|",2599,0,"Rattus norvegicus transmembrane inner ear (Tmie), mRNA","Q8K467",193,{"v":1e-55,"d":"1.00E-55"},"Transmembrane inner ear expressed protein",".",".",".",".","pfam06388","DUF1075","Protein of unknown function (DUF1075). This family consists of several eukaryotic proteins of unknown function.","GO:0007605|sensory perception of sound;GO:0008150|biological_process;GO:0042472|inner ear morphogenesis;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;","K23907","TMIE; transmembrane inner ear expressed protein"]
["ENSRNOG00000028879",10,0.830266605,3,0.192991315,4.302093113,2.10503875,0.015331656,0.011594583,"up","yes","Slc4a8","protein_coding","chr7:131864102-131931051:+","gi|50510613|dbj|BAD32292.1|",5483,0,"mKIAA0739 protein [Mus musculus]","gi|111494231|ref|NM_021530.2|",2883,0,"Mus musculus solute carrier family 4 (anion exchanger), member 8 (Slc4a8), mRNA","Q8JZR6",2105,0,"Electroneutral sodium bicarbonate exchanger 1",".",".",".",".","pfam00955","HCO3_cotransp","HCO3- transporter family. This family contains Band 3 anion exchange proteins that exchange CL-/HCO3-. This family also includes cotransporters of Na+/HCO3-.","GO:0015701|bicarbonate transport;GO:0035725|sodium ion transmembrane transport;GO:0042391|regulation of membrane potential;GO:0050801|ion homeostasis;GO:0050804|modulation of chemical synaptic transmission;GO:0051453|regulation of intracellular pH;GO:0055085|transmembrane transport;GO:1902476|chloride transmembrane transport;GO:2000302|positive regulation of synaptic vesicle exocytosis;","GO:0005886|plasma membrane;GO:0008021|synaptic vesicle;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0032279|asymmetric synapse;GO:0032280|symmetric synapse;GO:0032809|neuronal cell body membrane;GO:0042734|presynaptic membrane;GO:0043005|neuron projection;GO:0043195|terminal bouton;GO:0043679|axon terminus;GO:0097386|glial cell projection;GO:0097457|hippocampal mossy fiber;GO:0098793|presynapse;GO:0098978|glutamatergic synapse;","GO:0005452|inorganic anion exchanger activity;GO:0008510|sodium:bicarbonate symporter activity;GO:0015081|sodium ion transmembrane transporter activity;GO:0015106|bicarbonate transmembrane transporter activity;GO:0015108|chloride transmembrane transporter activity;GO:0015301|anion:anion antiporter activity;GO:0022857|transmembrane transporter activity;","K13859","SLC4A8; solute carrier family 4 (sodium bicarbonate cotransporter), member 8"]
["ENSRNOG00000006010",24,1.992639853,14,0.900626135,2.21250503,1.145680735,0.015782331,0.011896011,"up","yes","RGD1566368","protein_coding","chr8:123234714-123278680:-","gi|392350446|ref|XP_002730032.2|",3094,0,"PREDICTED: sodium- and chloride-dependent transporter XTRP3 isoform X2 [Rattus norvegicus]","gi|672063855|ref|XM_002729986.4|",3041,0,"PREDICTED: Rattus norvegicus similar to Solute carrier family 6 (neurotransmitter transporter), member 20 (RGD1566368), transcript variant X2, mRNA","O88575",1139,0,"Sodium- and chloride-dependent transporter XTRP3B","VC2012",154,{"v":2e-38,"d":"2.00E-38"},"COG0733","pfam00209","SNF","Sodium:neurotransmitter symporter family.","GO:0006865|amino acid transport;GO:0015816|glycine transport;GO:0015824|proline transport;GO:0015838|amino-acid betaine transport;GO:0035524|proline transmembrane transport;GO:0035725|sodium ion transmembrane transport;GO:0055085|transmembrane transport;GO:0089718|amino acid import across plasma membrane;GO:1904271|L-proline import across plasma membrane;GO:1905647|proline import across plasma membrane;","GO:0005887|integral component of plasma membrane;GO:0016324|apical plasma membrane;","GO:0005298|proline:sodium symporter activity;GO:0015171|amino acid transmembrane transporter activity;GO:0015175|neutral amino acid transmembrane transporter activity;GO:0015193|L-proline transmembrane transporter activity;GO:0015199|amino-acid betaine transmembrane transporter activity;GO:0015293|symporter activity;","K05048","SLC6A15S; solute carrier family 6 (neurotransmitter transporter, amino acid/orphan) member 15/16/17/18/20"]
["ENSRNOG00000012286",24,1.992639853,14,0.900626135,2.21250503,1.145680735,0.015782331,0.011896011,"up","yes","Il20ra","protein_coding","chr1:14451228-14493602:+","gi|157819773|ref|NP_001100991.1|",2773,0,"interleukin-20 receptor subunit alpha precursor [Rattus norvegicus]","gi|157819772|ref|NM_001107521.1|",2065,0,"Rattus norvegicus interleukin 20 receptor subunit alpha (Il20ra), mRNA","Q6PHB0",858,0,"Interleukin-20 receptor subunit alpha",".",".",".",".","pfam01108","Tissue_fac","Tissue factor. This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.","GO:0019221|cytokine-mediated signaling pathway;GO:0045124|regulation of bone resorption;GO:2001244|positive regulation of intrinsic apoptotic signaling pathway;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004896|cytokine receptor activity;GO:0042015|interleukin-20 binding;","K05136","IL20RA; interleukin 20 receptor alpha"]
["ENSRNOG00000024620",24,1.992639853,14,0.900626135,2.21250503,1.145680735,0.015782331,0.011896011,"up","yes","Mamdc2","protein_coding","chr1:220863976-221016354:-","gi|564298967|ref|XP_006223741.1|",3605,0,"PREDICTED: MAM domain-containing protein 2 isoform X1 [Rattus norvegicus]","gi|672014738|ref|XM_006223679.2|",3372,0,"PREDICTED: Rattus norvegicus MAM domain containing 2 (Mamdc2), transcript variant X1, mRNA","Q8CG85",1330,0,"MAM domain-containing protein 2",".",".",".",".","pfam00629","MAM","MAM domain. An extracellular domain found in many receptors.",".",".",".",".","."]
["ENSRNOG00000037406",25,2.075666513,15,0.964956573,2.151046557,1.10503875,0.016707374,0.012526816,"up","yes","RGD1564171","protein_coding","chr2:175507628-175510662:+","gi|148683219|gb|EDL15166.1|",518,{"v":7e-64,"d":"7.00E-64"},"mCG146184, partial [Mus musculus]","gi|157821840|ref|NM_001109186.1|",636,0,"Rattus norvegicus RGD1564171 (RGD1564171), mRNA",".",".",".",".",".",".",".",".","pfam15104","DUF4558","Domain of unknown function (DUF4558). This family of proteins is found in eukaryotes. Proteins in this family are typically between 78 and 121 amino acids in length. One member is annotated as being a flagellar associated protein.",".",".",".",".","."]
["ENSRNOG00000049045",25,2.075666513,15,0.964956573,2.151046557,1.10503875,0.016707374,0.012526816,"up","yes","AABR07045032.1","protein_coding","chr20:30335628-30373867:-","gi|21703836|ref|NP_663394.1|",4727,0,"putative hexokinase HKDC1 [Mus musculus]","gi|21703835|ref|NM_145419.1|",2535,0,"Mus musculus hexokinase domain containing 1 (Hkdc1), mRNA","Q91W97",1825,0,"Putative hexokinase HKDC1","SPAC24H6.04",282,{"v":5e-83,"d":"5.00E-83"},"COG5026","pfam03727","Hexokinase_2","Hexokinase. Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam00349. Some members of the family have two copies of each of these domains.",".",".",".",".","."]
["ENSRNOG00000067004",25,2.075666513,15,0.964956573,2.151046557,1.10503875,0.016707374,0.012526816,"up","yes","ENSRNOG00000067004","lncRNA","chr2:91935414-92030033:+",".",".",".",".","gi|124053518|gb|AC129945.10|",697,0,"Mus musculus chromosome 3, clone RP24-512A14, complete sequence",".",".",".",".",".",".",".",".","pfam14672","LCE","Late cornified envelope. This is a family of late cornified envelope proteins that are expressed in skin.",".",".",".",".","."]
["ENSRNOG00000016769",26,2.158693174,16,1.029287011,2.097270393,1.068512874,0.01755876,0.013082327,"up","yes","Rab38","protein_coding","chr1:142182556-142262924:+","gi|21955138|ref|NP_665717.1|",1137,{"v":3E-152,"d":"3.00E-152"},"ras-related protein Rab-38 [Rattus norvegicus]","gi|47125438|gb|BC070513.1|",1406,0,"Rattus norvegicus RAB38, member RAS oncogene family, mRNA (cDNA clone MGC:91458 IMAGE:7099841), complete cds","Q8QZZ8",438,{"v":5e-152,"d":"5.00E-152"},"Ras-related protein Rab-38",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0006886|intracellular protein transport;GO:0007005|mitochondrion organization;GO:0016192|vesicle-mediated transport;GO:0032438|melanosome organization;GO:0035646|endosome to melanosome transport;GO:0060155|platelet dense granule organization;GO:0072657|protein localization to membrane;GO:0090383|phagosome acidification;GO:1903232|melanosome assembly;GO:2001247|positive regulation of phosphatidylcholine biosynthetic process;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005764|lysosome;GO:0005769|early endosome;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005802|trans-Golgi network;GO:0005829|cytosol;GO:0012505|endomembrane system;GO:0016020|membrane;GO:0031982|vesicle;GO:0033162|melanosome membrane;GO:0042470|melanosome;GO:0044233|Mitochondria-associated ER Membrane;GO:0045335|phagocytic vesicle;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0019003|GDP binding;GO:0030742|GTP-dependent protein binding;GO:0035650|AP-1 adaptor complex binding;GO:0035651|AP-3 adaptor complex binding;GO:0036461|BLOC-2 complex binding;","K07923","RAB38; Ras-related protein Rab-38"]
["ENSRNOG00000001476",14,1.162373247,6,0.385982629,3.011465179,1.590465578,0.017809526,0.01324293,"up","yes","Cldn4","protein_coding","chr12:21751331-21753436:+","gi|58865612|ref|NP_001012022.1|",1035,{"v":1e-133,"d":"1.00E-133"},"claudin-4 [Rattus norvegicus]","gi|15799595|gb|AC091752.2|",2106,0,"Rattus norvegicus strain Brown Norway clone RP31-202M22, complete sequence","O35054",394,{"v":2E-131,"d":"2.00E-131"},"Claudin-4",".",".",".",".","pfam00822","PMP22_Claudin","PMP-22/EMP/MP20/Claudin family.","GO:0007155|cell adhesion;GO:0007565|female pregnancy;GO:0007623|circadian rhythm;GO:0015698|inorganic anion transport;GO:0022604|regulation of cell morphogenesis;GO:0030335|positive regulation of cell migration;GO:0032570|response to progesterone;GO:0061436|establishment of skin barrier;GO:0070293|renal absorption;GO:0070830|bicellular tight junction assembly;GO:0090303|positive regulation of wound healing;GO:1905050|positive regulation of metallopeptidase activity;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005911|cell-cell junction;GO:0005923|bicellular tight junction;GO:0009925|basal plasma membrane;GO:0016324|apical plasma membrane;GO:0016327|apicolateral plasma membrane;GO:0016328|lateral plasma membrane;GO:0070160|tight junction;","GO:0003674|molecular_function;GO:0005198|structural molecule activity;GO:0005254|chloride channel activity;","K06087","CLDN; claudin"]
["ENSRNOG00000003409",14,1.162373247,6,0.385982629,3.011465179,1.590465578,0.017809526,0.01324293,"up","yes","NEWGENE_1565644","protein_coding","chrX:139965509-140074355:+","gi|672032853|ref|XP_008756795.1|",694,{"v":3e-85,"d":"3.00E-85"},"PREDICTED: protein LDOC1 [Rattus norvegicus]","gi|672032852|ref|XM_008758573.1|",1354,0,"PREDICTED: Rattus norvegicus leucine zipper, down-regulated in cancer 1 (Ldoc1), transcript variant X1, mRNA","Q7TPY9",228,{"v":5e-70,"d":"5.00E-70"},"Protein LDOC1",".",".",".",".","pfam11279","DUF3080","Protein of unknown function (DUF3080). Some members in this family of proteins are annotated as lipoproteins however this cannot be confirmed. Currently this family has no known function.","GO:0001893|maternal placenta development;GO:0060137|maternal process involved in parturition;GO:0071222|cellular response to lipopolysaccharide;GO:0071225|cellular response to muramyl dipeptide;GO:1903547|regulation of growth hormone activity;","GO:0005654|nucleoplasm;GO:0005730|nucleolus;",".",".","."]
["ENSRNOG00000038183",14,1.162373247,6,0.385982629,3.011465179,1.590465578,0.017809526,0.01324293,"up","yes","Heatr4","protein_coding","chr6:103574366-103612100:-","gi|672056915|ref|XP_006240425.2|",5238,0,"PREDICTED: HEAT repeat-containing protein 4 isoform X1 [Rattus norvegicus]","gi|672056917|ref|XM_006240360.2|",3294,0,"PREDICTED: Rattus norvegicus similar to hypothetical MGC48595 (RGD1566220), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam13646","HEAT_2","HEAT repeats. This family includes multiple HEAT repeats.",".",".","GO:0016491|oxidoreductase activity;","K24813","HEATR4; HEAT repeat-containing protein 4"]
["ENSRNOG00000063700",14,1.162373247,6,0.385982629,3.011465179,1.590465578,0.017809526,0.01324293,"up","yes","ENSRNOG00000063700","protein_coding","chr2:5780381-5793496:+","gi|45478228|gb|AAS66285.1|",1390,0,"LRRGT00194 [Rattus norvegicus]","gi|31376407|gb|AC099101.7|",1518,0,"Rattus norvegicus 14 BAC CH230-186B23 (Children's Hospital Oakland Research Institute) complete sequence","P11369",497,0,"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam12488","DUF3704","Protein of unknown function (DUF3704). This domain family is found in eukaryotes, and is approximately 30 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000067275",14,1.162373247,6,0.385982629,3.011465179,1.590465578,0.017809526,0.01324293,"up","yes","ENSRNOG00000067275","lncRNA","chr17:75172754-75180279:+","gi|33086586|gb|AAP92605.1|",265,{"v":9e-22,"d":"9.00E-22"},"Ab2-389 [Rattus norvegicus]","gi|256985238|gb|AC118412.6|",822,0,"Rattus norvegicus CH230-221E17 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam11301","DUF3103","Protein of unknown function (DUF3103). This family of proteins with unknown function appear to be restricted to Proteobacteria.",".",".",".",".","."]
["ENSRNOG00000018101",19,1.57750655,10,0.643304382,2.452193075,1.294072575,0.018059626,0.013417979,"up","yes","Klc3","protein_coding","chr1:79045844-79055416:-","gi|564326478|ref|XP_006228440.1|",2196,0,"PREDICTED: kinesin light chain 3 isoform X3 [Rattus norvegicus]","gi|67678318|gb|BC097284.1|",1772,0,"Rattus norvegicus kinesin light chain 3, mRNA (cDNA clone MGC:114264 IMAGE:7454436), complete cds","Q68G30",846,0,"Kinesin light chain 3",".",".",".",".","pfam09311","Rab5-bind","Rabaptin-like protein. Members of this family are predominantly found in Rabaptin and allow for binding to the GTPase Rab5. This interaction is necessary and sufficient for Rab5-dependent recruitment of Rabaptin5 to early endosomal membranes.","GO:0008088|axo-dendritic transport;","GO:0005737|cytoplasm;GO:0005871|kinesin complex;GO:0005874|microtubule;GO:0031514|motile cilium;GO:0035253|ciliary rootlet;GO:0043005|neuron projection;","GO:0003777|microtubule motor activity;GO:0008017|microtubule binding;GO:0019894|kinesin binding;","K10407","KLC; kinesin light chain"]
["ENSRNOG00000019024",19,1.57750655,10,0.643304382,2.452193075,1.294072575,0.018059626,0.013417979,"up","yes","Trim67","protein_coding","chr19:52764387-52800422:+","gi|208973282|ref|NP_001129187.1|",3505,0,"tripartite motif-containing protein 67 [Rattus norvegicus]","gi|208973281|ref|NM_001135715.1|",2764,0,"Rattus norvegicus tripartite motif-containing 67 (Trim67), mRNA","Q505D9",1320,0,"Tripartite motif-containing protein 67",".",".",".",".","pfam00622","SPRY","SPRY domain. SPRY Domain is named from SPla and the RYanodine Receptor. Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.","GO:0010976|positive regulation of neuron projection development;GO:0046580|negative regulation of Ras protein signal transduction;GO:2000060|positive regulation of ubiquitin-dependent protein catabolic process;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;","GO:0008270|zinc ion binding;","K10649","TRIM9_67; tripartite motif-containing protein 9/67"]
["ENSRNOG00000020109",27,2.241719834,17,1.093617449,2.049820836,1.035497817,0.018338412,0.01358722,"up","yes","Dmrtc2","protein_coding","chr1:80466132-80473531:+","gi|672064497|ref|XP_008765121.1|",1736,0,"PREDICTED: doublesex- and mab-3-related transcription factor C2 isoform X1 [Rattus norvegicus]","gi|672064496|ref|XM_008766899.1|",2260,0,"PREDICTED: Rattus norvegicus doublesex- and mab-3-related transcription factor C2-like (LOC100910371), transcript variant X1, mRNA","Q8CGW9",611,0,"Doublesex- and mab-3-related transcription factor C2",".",".",".",".","pfam00751","DM","DM DNA binding domain. The DM domain is named after dsx and mab-3. dsx contains a single amino-terminal DM domain, whereas mab-3 contains two amino-terminal domains. The DM domain has a pattern of conserved zinc chelating residues C2H2C4. The dsx DM domain has been shown to dimerise and bind palindromic DNA.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0007141|male meiosis I;GO:0007281|germ cell development;GO:0007290|spermatid nucleus elongation;GO:0007548|sex differentiation;GO:1900111|positive regulation of histone H3-K9 dimethylation;GO:1900114|positive regulation of histone H3-K9 trimethylation;","GO:0001741|XY body;GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0042802|identical protein binding;GO:0043565|sequence-specific DNA binding;GO:0046872|metal ion binding;GO:1990837|sequence-specific double-stranded DNA binding;","K19493","DMRT7, DMRTC2; doublesex- and mab-3-related transcription factor 7"]
["ENSRNOG00000070389",27,2.241719834,17,1.093617449,2.049820836,1.035497817,0.018338412,0.01358722,"up","yes","ENSRNOG00000070389","lncRNA","chr11:3692631-3693841:-",".",".",".",".","gi|755555071|ref|XM_006523099.2|",527,0,"PREDICTED: Mus musculus vestigial like 3 (Drosophila) (Vgll3), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam10325","7TM_GPCR_Srz","Serpentine type 7TM GPCR chemoreceptor Srz. Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srz is a solo families amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srz appear to be under strong adaptive evolutionary pressure.",".",".",".",".","."]
["ENSRNOG00000026686",20,1.66053321,11,0.70763482,2.346596244,1.230569632,0.019684868,0.01448413,"up","yes","Ddx4","protein_coding","chr2:44227946-44282723:-","gi|380039264|gb|AFD32171.1|",3596,0,"putative ATP-dependent RNA helicase DDX4 [Rattus norvegicus]","gi|117647205|ref|NM_001077647.1|",2985,0,"Rattus norvegicus DEAD-box helicase 4 (Ddx4), mRNA","Q64060",1387,0,"Probable ATP-dependent RNA helicase DDX4",".",".",".",".","pfam00270","DEAD","DEAD/DEAH box helicase. Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolizm, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.","GO:0007140|male meiotic nuclear division;GO:0007141|male meiosis I;GO:0007276|gamete generation;GO:0007283|spermatogenesis;GO:0010529|negative regulation of transposition;GO:0030154|cell differentiation;GO:0030317|flagellated sperm motility;GO:0031047|gene silencing by RNA;GO:0032880|regulation of protein localization;GO:0034587|piRNA metabolic process;GO:0043046|DNA methylation involved in gamete generation;GO:1990511|piRNA biosynthetic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0033391|chromatoid body;GO:0043186|P granule;GO:0048471|perinuclear region of cytoplasm;GO:0071546|pi-body;GO:0071547|piP-body;GO:1990904|ribonucleoprotein complex;","GO:0003676|nucleic acid binding;GO:0003723|RNA binding;GO:0003724|RNA helicase activity;GO:0005524|ATP binding;GO:0016787|hydrolase activity;","K13982","DDX4, VASA; probable ATP-dependent RNA helicase DDX4 [EC:3.6.4.13]"]
["ENSRNOG00000002624",8,0.664213284,2,0.128660876,5.162511736,2.368073156,0.019765992,0.014513758,"up","yes","Edaradd","protein_coding","chr17:85656905-85910447:-","gi|392334034|ref|XP_001054456.3|",1099,{"v":3e-140,"d":"3.00E-140"},"PREDICTED: ectodysplasin-A receptor-associated adapter protein isoform X2 [Rattus norvegicus]","gi|672082657|ref|XM_574055.6|",2117,0,"PREDICTED: Rattus norvegicus EDAR-associated death domain (Edaradd), transcript variant X2, mRNA","Q8VHX2",372,{"v":3e-120,"d":"3.00E-120"},"Ectodysplasin-A receptor-associated adapter protein",".",".",".",".","pfam00531","Death","Death domain.","GO:0001942|hair follicle development;GO:0007165|signal transduction;GO:0042475|odontogenesis of dentin-containing tooth;GO:0061153|trachea gland development;GO:1901224|positive regulation of NIK/NF-kappaB signaling;",".",".","K23324","EDARADD; ectodysplasin-A receptor-associated adapter protein"]
["ENSRNOG00000003442",8,0.664213284,2,0.128660876,5.162511736,2.368073156,0.019765992,0.014513758,"up","yes","Adora1","protein_coding","chr13:45658872-45695801:-","gi|148707674|gb|EDL39621.1|",1407,{"v":2e-177,"d":"2.00E-177"},"mCG50903, isoform CRA_a, partial [Mus musculus]","gi|672074076|ref|XM_006249859.2|",2477,0,"PREDICTED: Rattus norvegicus adenosine A1 receptor (Adora1), transcript variant X1, mRNA","P25099",544,{"v":3e-178,"d":"3.00E-178"},"Adenosine receptor A1",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001659|temperature homeostasis;GO:0001666|response to hypoxia;GO:0001973|adenosine receptor signaling pathway;GO:0002087|regulation of respiratory gaseous exchange by neurological system process;GO:0002674|negative regulation of acute inflammatory response;GO:0002686|negative regulation of leukocyte migration;GO:0002793|positive regulation of peptide secretion;GO:0003084|positive regulation of systemic arterial blood pressure;GO:0003085|negative regulation of systemic arterial blood pressure;GO:0003093|regulation of glomerular filtration;GO:0006612|protein targeting to membrane;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007193|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0008285|negative regulation of cell proliferation;GO:0010996|response to auditory stimulus;GO:0014050|negative regulation of glutamate secretion;GO:0016042|lipid catabolic process;GO:0032229|negative regulation of synaptic transmission, GABAergic;GO:0032244|positive regulation of nucleoside transport;GO:0032900|negative regulation of neurotrophin production;GO:0035307|positive regulation of protein dephosphorylation;GO:0035814|negative regulation of renal sodium excretion;GO:0042310|vasoconstriction;GO:0042311|vasodilation;GO:0042321|negative regulation of circadian sleep/wake cycle, sleep;GO:0042323|negative regulation of circadian sleep/wake cycle, non-REM sleep;GO:0043066|negative regulation of apoptotic process;GO:0043268|positive regulation of potassium ion transport;GO:0043410|positive regulation of MAPK cascade;GO:0045741|positive regulation of epidermal growth factor-activated receptor activity;GO:0045776|negative regulation of blood pressure;GO:0045777|positive regulation of blood pressure;GO:0045822|negative regulation of heart contraction;GO:0046888|negative regulation of hormone secretion;GO:0050728|negative regulation of inflammatory response;GO:0050890|cognition;GO:0050965|detection of temperature stimulus involved in sensory perception of pain;GO:0050995|negative regulation of lipid catabolic process;GO:0050996|positive regulation of lipid catabolic process;GO:0051930|regulation of sensory perception of pain;GO:0051967|negative regulation of synaptic transmission, glutamatergic;GO:0055089|fatty acid homeostasis;GO:0055117|regulation of cardiac muscle contraction;GO:0060079|excitatory postsynaptic potential;GO:0060087|relaxation of vascular smooth muscle;GO:0070256|negative regulation of mucus secretion;GO:0070328|triglyceride homeostasis;GO:0086004|regulation of cardiac muscle cell contraction;GO:0099509|regulation of presynaptic cytosolic calcium ion concentration;GO:1900272|negative regulation of long-term synaptic potentiation;GO:1900453|negative regulation of long-term synaptic depression;GO:1901216|positive regulation of neuron death;","GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0012505|endomembrane system;GO:0014069|postsynaptic density;GO:0016323|basolateral plasma membrane;GO:0030425|dendrite;GO:0030673|axolemma;GO:0032279|asymmetric synapse;GO:0042734|presynaptic membrane;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0043197|dendritic spine;GO:0044297|cell body;GO:0044305|calyx of Held;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0048786|presynaptic active zone;GO:0099055|integral component of postsynaptic membrane;GO:0099056|integral component of presynaptic membrane;","GO:0001609|G protein-coupled adenosine receptor activity;GO:0001664|G protein-coupled receptor binding;GO:0001883|purine nucleoside binding;GO:0005515|protein binding;GO:0031072|heat shock protein binding;GO:0031683|G-protein beta/gamma-subunit complex binding;GO:0032795|heterotrimeric G-protein binding;GO:0044877|protein-containing complex binding;GO:0046982|protein heterodimerization activity;GO:0099582|neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration;","K04265","ADORA1; adenosine receptor A1"]
["ENSRNOG00000004404",8,0.664213284,2,0.128660876,5.162511736,2.368073156,0.019765992,0.014513758,"up","yes","Tac4","protein_coding","chr10:80207610-80216156:+","gi|27229228|ref|NP_758831.1|",833,{"v":2E-107,"d":"2.00E-107"},"tachykinin-4 preproprotein [Rattus norvegicus]","gi|54262187|ref|NM_172328.2|",1083,0,"Rattus norvegicus tachykinin 4 (hemokinin) (Tac4), mRNA","Q8CH01",325,{"v":8e-109,"d":"8.00E-109"},"Tachykinin-4",".",".",".",".","pfam05463","Sclerostin","Sclerostin (SOST). This family contains several mammalian sclerostin (SOST) proteins. SOST is thought to suppress bone formation. Mutations of the SOST gene lead to sclerosteosis, a progressive sclerosing bone dysplasia with an autosomal recessive mode of inheritance. Radiologically, it is characterized by a generalised hyperostosis and sclerosis leading to a markedly thickened and sclerotic skull, with mandible, ribs, clavicles and all long bones also being affected. Due to narrowing of the foramina of the cranial nerves, facial nerve palsy, hearing loss and atrophy of the optic nerves can occur. Sclerosteosis is clinically and radiologically very similar to van Buchem disease, mainly differentiated by hand malformations and a large stature in sclerosteosis patients.","GO:0003085|negative regulation of systemic arterial blood pressure;GO:0006954|inflammatory response;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007217|tachykinin receptor signaling pathway;GO:0008217|regulation of blood pressure;GO:0043303|mast cell degranulation;GO:0046878|positive regulation of saliva secretion;GO:0050965|detection of temperature stimulus involved in sensory perception of pain;GO:0051930|regulation of sensory perception of pain;GO:1902093|positive regulation of flagellated sperm motility;GO:1904057|negative regulation of sensory perception of pain;GO:1904058|positive regulation of sensory perception of pain;","GO:0005615|extracellular space;","GO:0005102|signaling receptor binding;GO:0031835|substance P receptor binding;GO:0031837|substance K receptor binding;GO:0048018|receptor ligand activity;","K05241","TAC4; tachykinin 4"]
["ENSRNOG00000014227",8,0.664213284,2,0.128660876,5.162511736,2.368073156,0.019765992,0.014513758,"up","yes","Mrgprx3","protein_coding","chr1:97721436-97746900:-","gi|59709471|ref|NP_665730.2|",1457,0,"mas-related G-protein coupled receptor member A [Rattus norvegicus]","gi|59709470|ref|NM_145787.2|",1285,0,"Rattus norvegicus MAS related GPR family member X3 (Mrgprx3), mRNA","Q7TN49",513,{"v":2E-180,"d":"2.00E-180"},"Mas-related G-protein coupled receptor member A",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0007218|neuropeptide signaling pathway;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0008188|neuropeptide receptor activity;","K08396","MRGPRX; Mas-related G protein-coupled receptor member X"]
["ENSRNOG00000017683",8,0.664213284,2,0.128660876,5.162511736,2.368073156,0.019765992,0.014513758,"up","yes","Adam18","protein_coding","chr16:67352416-67425248:+","gi|672080592|ref|XP_008769591.1|",3767,0,"PREDICTED: disintegrin and metalloproteinase domain-containing protein 18 isoform X1 [Rattus norvegicus]","gi|672080591|ref|XM_008771369.1|",2106,0,"PREDICTED: Rattus norvegicus ADAM metallopeptidase domain 18 (Adam18), transcript variant X2, mRNA","Q9R157",1243,0,"Disintegrin and metalloproteinase domain-containing protein 18",".",".",".",".","pfam01421","Reprolysin","Reprolysin (M12B) family zinc metalloprotease. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as human ADAM8 and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.","GO:0006508|proteolysis;GO:0007155|cell adhesion;GO:0007283|spermatogenesis;GO:0007339|binding of sperm to zona pellucida;GO:0030154|cell differentiation;","GO:0016021|integral component of membrane;","GO:0004222|metalloendopeptidase activity;","K16909","ADAM18; disintegrin and metalloproteinase domain-containing protein 18 [EC:3.4.24.-]"]
["ENSRNOG00000020377",8,0.664213284,2,0.128660876,5.162511736,2.368073156,0.019765992,0.014513758,"up","yes","Cideb","protein_coding","chr15:29252213-29256605:-","gi|564386225|ref|XP_006252064.1|",987,{"v":3e-128,"d":"3.00E-128"},"PREDICTED: cell death activator CIDE-B isoform X1 [Rattus norvegicus]","gi|672078087|ref|XM_006252002.2|",696,0,"PREDICTED: Rattus norvegicus cell death-inducing DFFA-like effector b (Cideb), transcript variant X1, mRNA","O70303",280,{"v":1E-89,"d":"1.00E-89"},"Cell death activator CIDE-B",".",".",".",".","pfam02017","CIDE-N","CIDE-N domain. This domain is found in CAD nuclease, and in ICAD, the inhibitor of CAD nuclease. The two proteins interact through this domain.","GO:0006915|apoptotic process;GO:0010942|positive regulation of cell death;GO:0031667|response to nutrient levels;GO:0038183|bile acid signaling pathway;GO:0042981|regulation of apoptotic process;GO:0090200|positive regulation of release of cytochrome c from mitochondria;GO:0097194|execution phase of apoptosis;GO:0097202|activation of cysteine-type endopeptidase activity;","GO:0005829|cytosol;GO:0048471|perinuclear region of cytoplasm;","GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000029262",8,0.664213284,2,0.128660876,5.162511736,2.368073156,0.019765992,0.014513758,"up","yes","AABR07053166.1","protein_coding","chr3:91267220-91267774:-","gi|914905019|ref|XP_013213065.1|",875,{"v":2e-117,"d":"2.00E-117"},"PREDICTED: 60S ribosomal protein L17 [Ictidomys tridecemlineatus]","gi|57681|emb|X58389.1|",504,0,"Rat mRNA for ribosomal protein L17","P24049",341,{"v":9e-119,"d":"9.00E-119"},"60S ribosomal protein L17","YKL180w",199,{"v":1e-63,"d":"1.00E-63"},"COG0091","pfam00237","Ribosomal_L22","Ribosomal protein L22p/L17e. This family includes L22 from prokaryotes and chloroplasts and L17 from eukaryotes.",".",".",".",".","."]
["ENSRNOG00000030983",8,0.664213284,2,0.128660876,5.162511736,2.368073156,0.019765992,0.014513758,"up","yes","B3galt5","protein_coding","chr11:35585220-35630917:+","gi|157786822|ref|NP_001099357.1|",1590,0,"beta-1,3-galactosyltransferase 5 [Rattus norvegicus]","gi|672070546|ref|XM_008768569.1|",5164,0,"PREDICTED: Rattus norvegicus UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 (B3galt5), transcript variant X1, mRNA","Q9JI67",596,0,"Beta-1,3-galactosyltransferase 5",".",".",".",".","pfam01762","Galactosyl_T","Galactosyltransferase. This family includes the galactosyltransferases UDP-galactose:2-acetamido-2-deoxy-D-glucose3beta-galactosyltransferase and UDP-Gal:beta-GlcNAc beta 1,3-galactosyltranferase. Specific galactosyltransferases transfer galactose to GlcNAc terminal chains in the synthesis of the lacto-series oligosaccharides types 1 and 2.","GO:0006486|protein glycosylation;GO:0008150|biological_process;GO:0009617|response to bacterium;","GO:0000139|Golgi membrane;GO:0005575|cellular_component;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0008194|UDP-glycosyltransferase activity;GO:0008499|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity;GO:0016757|transferase activity, transferring glycosyl groups;","K03877","B3GALT5; beta-1,3-galactosyltransferase 5 [EC:2.4.1.-]"]
["ENSRNOG00000045905",8,0.664213284,2,0.128660876,5.162511736,2.368073156,0.019765992,0.014513758,"up","yes","Kdm4d","protein_coding","chr8:11268859-11305290:-","gi|119310200|ref|NP_001073180.1|",2777,0,"lysine-specific demethylase 4D [Rattus norvegicus]","gi|392349816|ref|XM_003750432.1|",2699,0,"PREDICTED: Rattus norvegicus lysine-specific demethylase 4D-like (LOC100909834), mRNA","A1A5Q5",1074,0,"Lysine-specific demethylase 4D",".",".",".",".","pfam02373","JmjC","JmjC domain, hydroxylase. The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyse a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalyzing hydroxylation.","GO:0000724|double-strand break repair via homologous recombination;GO:0001932|regulation of protein phosphorylation;GO:0006338|chromatin remodeling;GO:0006974|cellular response to DNA damage stimulus;GO:0008150|biological_process;GO:0033169|histone H3-K9 demethylation;GO:0035563|positive regulation of chromatin binding;GO:0071479|cellular response to ionizing radiation;GO:1900113|negative regulation of histone H3-K9 trimethylation;GO:2001034|positive regulation of double-strand break repair via nonhomologous end joining;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005721|pericentric heterochromatin;GO:0035861|site of double-strand break;","GO:0003674|molecular_function;GO:0003684|damaged DNA binding;GO:0031490|chromatin DNA binding;GO:0032452|histone demethylase activity;GO:0032454|histone demethylase activity (H3-K9 specific);GO:0046872|metal ion binding;GO:0051213|dioxygenase activity;","K06709","KDM4, JMJD2, JHDM3; [histone H3]-trimethyl-L-lysine9/36 demethylase [EC:1.14.11.66 1.14.11.69]"]
["ENSRNOG00000048169",8,0.664213284,2,0.128660876,5.162511736,2.368073156,0.019765992,0.014513758,"up","yes","Tuba8","protein_coding","chr4:154440074-154456917:+","gi|672050904|ref|XP_008761476.1|",2394,0,"PREDICTED: tubulin alpha-8 chain isoform X1 [Rattus norvegicus]","gi|672050903|ref|XM_008763254.1|",1587,0,"PREDICTED: Rattus norvegicus tubulin, alpha 8 (Tuba8), transcript variant X1, mRNA","Q6AY56",892,0,"Tubulin alpha-8 chain","SPBC800.05c",711,0,"COG5023","pfam03953","Tubulin_C","Tubulin C-terminal domain. This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).","GO:0000226|microtubule cytoskeleton organization;GO:0000278|mitotic cell cycle;","GO:0005737|cytoplasm;GO:0005874|microtubule;GO:0015630|microtubule cytoskeleton;","GO:0003924|GTPase activity;GO:0005200|structural constituent of cytoskeleton;GO:0005525|GTP binding;","K07374","TUBA; tubulin alpha"]
["ENSRNOG00000051015",8,0.664213284,2,0.128660876,5.162511736,2.368073156,0.019765992,0.014513758,"up","yes","Cd70","protein_coding","chr9:2006563-2009715:-","gi|157822647|ref|NP_001100348.1|",1012,{"v":2E-136,"d":"2.00E-136"},"CD70 antigen [Rattus norvegicus]","gi|157822646|ref|NM_001106878.1|",821,0,"Rattus norvegicus Cd70 molecule (Cd70), mRNA","O55237",291,{"v":2e-97,"d":"2.00E-97"},"CD70 antigen",".",".",".",".","pfam00229","TNF","TNF(tumor Necrosis Factor) family.","GO:0002456|T cell mediated immunity;GO:0019724|B cell mediated immunity;GO:0033209|tumor necrosis factor-mediated signaling pathway;GO:0042100|B cell proliferation;GO:0097191|extrinsic apoptotic signaling pathway;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0002020|protease binding;GO:0005125|cytokine activity;GO:0005164|tumor necrosis factor receptor binding;","K05470","TNFSF7, CD70; tumor necrosis factor ligand superfamily member 7"]
["ENSRNOG00000057996",8,0.664213284,2,0.128660876,5.162511736,2.368073156,0.019765992,0.014513758,"up","yes","Phactr3","protein_coding","chr3:165205255-165423153:+","gi|47523968|ref|NP_999624.1|",2346,0,"phosphatase and actin regulator 3 [Rattus norvegicus]","gi|295317314|ref|NM_028806.2|",1725,0,"Mus musculus phosphatase and actin regulator 3 (Phactr3), transcript variant 1, mRNA","Q6RFY2",908,0,"Phosphatase and actin regulator 3",".",".",".",".","pfam02755","RPEL","RPEL repeat. The RPEL repeat is named after four conserved amino acids it contains. The function of the RPEL repeat is unknown however it might be a DNA binding repeat based on the observation that he Drosophila myocardin-related transcription factor contains a pfam02037 domain that is also implicated in DNA binding.","GO:0030036|actin cytoskeleton organization;GO:0043086|negative regulation of catalytic activity;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0016363|nuclear matrix;","GO:0003779|actin binding;GO:0004864|protein phosphatase inhibitor activity;GO:0008157|protein phosphatase 1 binding;","K17594","PHACTR; phosphatase and actin regulator"]
["ENSRNOG00000069220",8,0.664213284,2,0.128660876,5.162511736,2.368073156,0.019765992,0.014513758,"up","yes","ENSRNOG00000069220","lncRNA","chr11:57581665-57588915:+",".",".",".",".","gi|68448665|gb|AC158170.2|",50,{"v":5E-15,"d":"5.00E-15"},"Mus musculus BAC clone RP23-261K17 from chromosome 16, complete sequence",".",".",".",".",".",".",".",".","pfam13771","zf-HC5HC2H","PHD-like zinc-binding domain. The members of this family are annotated as containing PHD domain, but the zinc-binding region here is not typical of PHD domains. The conformation here is a well-conserved cysteine-histidine rich region spanning 90 residues, where the Cys and His are arranged as HxxC(31)CxxC(6)CxxCxxxxCxxxxHxxC (21)CxxH.",".",".",".",".","."]
["ENSRNOG00000069672",8,0.664213284,2,0.128660876,5.162511736,2.368073156,0.019765992,0.014513758,"up","yes","ENSRNOG00000069672","lncRNA","chr4:169953943-169968532:+",".",".",".",".","gi|672018874|ref|XR_600874.1|",563,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102551171 (LOC102551171), ncRNA",".",".",".",".",".",".",".",".","pfam02438","Adeno_100","Late 100kD protein. The late 100kD protein is a non-structural viral protein involved in the transport of hexon from the cytoplasm to the nucleus.",".",".",".",".","."]
["ENSRNOG00000001924",11,0.913293266,4,0.257321753,3.549226818,1.827504775,0.02054205,0.015023219,"up","yes","Tp63","protein_coding","chr11:74838859-75049398:-","gi|9507209|ref|NP_062094.1|",3525,0,"tumor protein 63 isoform a [Rattus norvegicus]","gi|189083852|ref|NM_019221.3|",4960,0,"Rattus norvegicus tumor protein p63 (Tp63), transcript variant 1, mRNA","Q9JJP6",1360,0,"Tumor protein 63",".",".",".",".","pfam00870","P53","P53 DNA-binding domain. This family contains one anomalous member, viz: Zea mays (Q6JAD8). This sequence is identical to human P53 and would appear to be a a human contaminant within the Zea mays sampling effort.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001501|skeletal system development;GO:0001736|establishment of planar polarity;GO:0001738|morphogenesis of a polarized epithelium;GO:0001942|hair follicle development;GO:0002053|positive regulation of mesenchymal cell proliferation;GO:0002064|epithelial cell development;GO:0006338|chromatin remodeling;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006974|cellular response to DNA damage stimulus;GO:0007219|Notch signaling pathway;GO:0007283|spermatogenesis;GO:0007389|pattern specification process;GO:0007499|ectoderm and mesoderm interaction;GO:0007568|aging;GO:0007569|cell aging;GO:0008283|cell proliferation;GO:0008284|positive regulation of cell proliferation;GO:0008544|epidermis development;GO:0009887|animal organ morphogenesis;GO:0009913|epidermal cell differentiation;GO:0009954|proximal/distal pattern formation;GO:0010259|multicellular organism aging;GO:0010481|epidermal cell division;GO:0010482|regulation of epidermal cell division;GO:0010838|positive regulation of keratinocyte proliferation;GO:0030154|cell differentiation;GO:0030216|keratinocyte differentiation;GO:0030326|embryonic limb morphogenesis;GO:0030850|prostate gland development;GO:0030855|epithelial cell differentiation;GO:0030859|polarized epithelial cell differentiation;GO:0031069|hair follicle morphogenesis;GO:0033147|negative regulation of intracellular estrogen receptor signaling pathway;GO:0035115|embryonic forelimb morphogenesis;GO:0035116|embryonic hindlimb morphogenesis;GO:0036342|post-anal tail morphogenesis;GO:0042475|odontogenesis of dentin-containing tooth;GO:0042771|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0043066|negative regulation of apoptotic process;GO:0043281|regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043589|skin morphogenesis;GO:0043616|keratinocyte proliferation;GO:0045617|negative regulation of keratinocyte differentiation;GO:0045669|positive regulation of osteoblast differentiation;GO:0045747|positive regulation of Notch signaling pathway;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048485|sympathetic nervous system development;GO:0048646|anatomical structure formation involved in morphogenesis;GO:0048745|smooth muscle tissue development;GO:0048807|female genitalia morphogenesis;GO:0051262|protein tetramerization;GO:0051402|neuron apoptotic process;GO:0060157|urinary bladder development;GO:0060197|cloacal septation;GO:0060513|prostatic bud formation;GO:0060529|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development;GO:0061436|establishment of skin barrier;GO:0098773|skin epidermis development;GO:1902808|positive regulation of cell cycle G1/S phase transition;GO:1904674|positive regulation of somatic stem cell population maintenance;GO:1904888|cranial skeletal system development;GO:2000271|positive regulation of fibroblast apoptotic process;GO:2000381|negative regulation of mesoderm development;GO:2000773|negative regulation of cellular senescence;GO:2001235|positive regulation of apoptotic signaling pathway;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005791|rough endoplasmic reticulum;GO:0030425|dendrite;GO:0032991|protein-containing complex;GO:0043005|neuron projection;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0002039|p53 binding;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003684|damaged DNA binding;GO:0003690|double-stranded DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0019904|protein domain specific binding;GO:0042802|identical protein binding;GO:0043565|sequence-specific DNA binding;GO:0046872|metal ion binding;GO:0050699|WW domain binding;GO:0097371|MDM2/MDM4 family protein binding;","K10149","TP63; tumor protein p63"]
["ENSRNOG00000031607",11,0.913293266,4,0.257321753,3.549226818,1.827504775,0.02054205,0.015023219,"up","yes","ENSRNOG00000031607","protein_coding","chr20:2623953-2692081:+","gi|569017019|ref|XP_006536911.1|",1342,{"v":7e-180,"d":"7.00E-180"},"PREDICTED: predicted gene 7030 isoform X3 [Mus musculus]","gi|755569189|ref|XM_006536848.2|",654,0,"PREDICTED: Mus musculus predicted gene 7030 (Gm7030), transcript variant X3, mRNA","P03991",428,{"v":3e-145,"d":"3.00E-145"},"H-2 class I histocompatibility antigen, K-W28 alpha chain",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.","GO:0001916|positive regulation of T cell mediated cytotoxicity;GO:0002476|antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002486|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0006955|immune response;","GO:0005615|extracellular space;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0005102|signaling receptor binding;GO:0042605|peptide antigen binding;","K06751","MHC1; MHC class I antigen"]
["ENSRNOG00000008919",15,1.245399908,7,0.450313067,2.765631287,1.46760883,0.020779898,0.015146925,"up","yes","Arpp21","protein_coding","chr8:112034642-112194297:-","gi|672063432|ref|XP_008764858.1|",3694,0,"PREDICTED: cAMP-regulated phosphoprotein 21 isoform X3 [Rattus norvegicus]","gi|672063431|ref|XM_008766636.1|",3261,0,"PREDICTED: Rattus norvegicus cAMP-regulated phosphoprotein 21 (Arpp21), transcript variant X12, mRNA","Q9DCB4",1288,0,"cAMP-regulated phosphoprotein 21",".",".",".",".","pfam07223","DUF1421","Protein of unknown function (DUF1421). This family represents a conserved region approximately 350 residues long within a number of plant proteins of unknown function.","GO:0034605|cellular response to heat;","GO:0005737|cytoplasm;","GO:0003676|nucleic acid binding;",".","."]
["ENSRNOG00000013906",15,1.245399908,7,0.450313067,2.765631287,1.46760883,0.020779898,0.015146925,"up","yes","Gpat2","protein_coding","chr3:114648498-114657051:+","gi|270483856|ref|NP_001162001.1|",3627,0,"glycerol-3-phosphate acyltransferase 2, mitochondrial [Rattus norvegicus]","gi|270483855|ref|NM_001168529.1|",2617,0,"Rattus norvegicus glycerol-3-phosphate acyltransferase 2, mitochondrial (Gpat2), mRNA","Q14DK4",1345,0,"Glycerol-3-phosphate acyltransferase 2, mitochondrial",".",".",".",".","pfam06346","Drf_FH1","Formin Homology Region 1. This region is found in some of the Diaphanous related formins (Drfs). It consists of low complexity repeats of around 12 residues.","GO:0006072|glycerol-3-phosphate metabolic process;GO:0006631|fatty acid metabolic process;GO:0006654|phosphatidic acid biosynthetic process;GO:0008150|biological_process;GO:0008654|phospholipid biosynthetic process;GO:0016024|CDP-diacylglycerol biosynthetic process;GO:0019432|triglyceride biosynthetic process;GO:1990511|piRNA biosynthetic process;","GO:0005575|cellular_component;GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0016021|integral component of membrane;GO:0031966|mitochondrial membrane;","GO:0003674|molecular_function;GO:0003841|1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0004366|glycerol-3-phosphate O-acyltransferase activity;GO:0102420|sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity;","K00629","GPAT1_2; glycerol-3-phosphate O-acyltransferase 1/2 [EC:2.3.1.15]"]
["ENSRNOG00000034150",21,1.743559871,12,0.771965258,2.258598884,1.175428078,0.021182036,0.015413695,"up","yes","AABR07041778.1","protein_coding","chrX:131765916-131766839:-","gi|84000579|ref|NP_071945.3|",806,{"v":6e-105,"d":"6.00E-105"},"ferritin light chain 1 [Rattus norvegicus]","gi|298906866|emb|FQ228585.1|",876,0,"Rattus norvegicus TL0ADA6YH21 mRNA sequence","P02793",315,{"v":2e-106,"d":"2.00E-106"},"Ferritin light chain 1",".",".",".",".","pfam00210","Ferritin","Ferritin-like domain. This family contains ferritins and other ferritin-like proteins such as members of the DPS family and bacterioferritins.","GO:0006826|iron ion transport;",".",".",".","."]
["ENSRNOG00000005367",5,0.415133303,0,0.032165219,12.90627934,3.690001251,0.022406192,0.016171974,"up","yes","Slc12a1","protein_coding","chr3:112406140-112482899:+","gi|672046762|ref|XP_008760365.1|",5535,0,"PREDICTED: solute carrier family 12 member 1 isoform X3 [Rattus norvegicus]","gi|672046755|ref|XM_008762140.1|",4785,0,"PREDICTED: Rattus norvegicus solute carrier family 12 (sodium/potassium/chloride transporter), member 1 (Slc12a1), transcript variant X1, mRNA","P55014",2043,0,"Solute carrier family 12 member 1","SPBC18H10.16",206,{"v":3e-53,"d":"3.00E-53"},"COG0531","pfam00324","AA_permease","Amino acid permease.","GO:0001822|kidney development;GO:0006813|potassium ion transport;GO:0006814|sodium ion transport;GO:0006821|chloride transport;GO:0006884|cell volume homeostasis;GO:0007588|excretion;GO:0015698|inorganic anion transport;GO:0016101|diterpenoid metabolic process;GO:0032978|protein insertion into membrane from inner side;GO:0034220|ion transmembrane transport;GO:0035725|sodium ion transmembrane transport;GO:0048878|chemical homeostasis;GO:0055064|chloride ion homeostasis;GO:0055075|potassium ion homeostasis;GO:0055078|sodium ion homeostasis;GO:0055085|transmembrane transport;GO:0070294|renal sodium ion absorption;GO:0070886|positive regulation of calcineurin-NFAT signaling cascade;GO:0071475|cellular hyperosmotic salinity response;GO:1902476|chloride transmembrane transport;GO:1990573|potassium ion import across plasma membrane;","GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0070062|extracellular exosome;","GO:0008511|sodium:potassium:chloride symporter activity;GO:0015377|cation:chloride symporter activity;GO:0015379|potassium:chloride symporter activity;","K14425","SLC12A1, NKCC2; solute carrier family 12 (sodium/potassium/chloride transporter), member 1"]
["ENSRNOG00000007420",5,0.415133303,0,0.032165219,12.90627934,3.690001251,0.022406192,0.016171974,"up","yes","Hrh1","protein_coding","chr4:147645995-147647455:+","gi|149036950|gb|EDL91568.1|",2520,0,"rCG56382, isoform CRA_b [Rattus norvegicus]","gi|8393563|ref|NM_017018.1|",1449,0,"Rattus norvegicus histamine receptor H 1 (Hrh1), mRNA","P31390",972,0,"Histamine H1 receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0007187|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007199|G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger;GO:0007268|chemical synaptic transmission;GO:0007613|memory;GO:0008542|visual learning;GO:0009629|response to gravity;GO:0010894|negative regulation of steroid biosynthetic process;GO:0043114|regulation of vascular permeability;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0045907|positive regulation of vasoconstriction;GO:0048167|regulation of synaptic plasticity;GO:0048245|eosinophil chemotaxis;GO:0071420|cellular response to histamine;GO:0098664|G protein-coupled serotonin receptor signaling pathway;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0045202|synapse;","GO:0004969|histamine receptor activity;GO:0004993|G protein-coupled serotonin receptor activity;GO:0030594|neurotransmitter receptor activity;GO:0051381|histamine binding;","K04149","HRH1; histamine receptor H1"]
["ENSRNOG00000012119",5,0.415133303,0,0.032165219,12.90627934,3.690001251,0.022406192,0.016171974,"up","yes","AABR07069282.1","protein_coding","chr8:13946699-13948030:+","gi|392341757|ref|XP_003754418.1|",2242,0,"PREDICTED: serine/threonine-protein kinase Nek2-like [Rattus norvegicus]","gi|672022541|ref|XM_003754370.3|",1332,0,"PREDICTED: Rattus norvegicus NIMA (never in mitosis gene a)-related kinase 2-like 1 (Nek2l1), mRNA","O35942",822,0,"Serine/threonine-protein kinase Nek2",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.",".",".",".",".","."]
["ENSRNOG00000012723",5,0.415133303,0,0.032165219,12.90627934,3.690001251,0.022406192,0.016171974,"up","yes","Trim55","protein_coding","chr2:102088443-102142168:+","gi|564335946|ref|XP_006232243.1|",2424,0,"PREDICTED: tripartite motif-containing protein 55 isoform X1 [Rattus norvegicus]","gi|672041913|ref|XM_006232181.2|",1829,0,"PREDICTED: Rattus norvegicus tripartite motif-containing 55 (Trim55), transcript variant X1, mRNA","Q5PQN5",901,0,"Tripartite motif-containing protein 55",".",".",".",".","pfam13923","zf-C3HC4_2","Zinc finger, C3HC4 type (RING finger).","GO:0002522|leukocyte migration involved in immune response;GO:0002523|leukocyte migration involved in inflammatory response;GO:0016567|protein ubiquitination;GO:0050904|diapedesis;GO:1905517|macrophage migration;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0008270|zinc ion binding;GO:0042802|identical protein binding;GO:0061630|ubiquitin protein ligase activity;","K10654","TRIM55, MURF2; tripartite motif-containing protein 55"]
["ENSRNOG00000013334",5,0.415133303,0,0.032165219,12.90627934,3.690001251,0.022406192,0.016171974,"up","yes","Clca5","protein_coding","chr2:233796575-233818949:-","gi|61557272|ref|NP_001013220.1|",4491,0,"chloride channel calcium activated 2 precursor [Rattus norvegicus]","gi|402692916|ref|NM_001013202.2|",3116,0,"Rattus norvegicus chloride channel calcium activated 2 (Clca2), mRNA","Q9QX15",1446,0,"Calcium-activated chloride channel regulator 3A-1","sll0103",52,8e-06,"COG2304","pfam08434","CLCA_N","Calcium-activated chloride channel. The CLCA family of calcium-activated chloride channels has been identified in many epithelial and endothelial cell types as well as in smooth muscle cells and has four or five putative transmembrane regions. Additionally to their role as chloride channels some CLCA proteins function as adhesion molecules and may also have roles as tumor suppressors. The domain described here is found at the N-terminus of CLCAs.","GO:0006508|proteolysis;GO:0006821|chloride transport;GO:0015698|inorganic anion transport;","GO:0005887|integral component of plasma membrane;","GO:0005229|intracellular calcium activated chloride channel activity;GO:0008237|metallopeptidase activity;GO:0046872|metal ion binding;","K05030","CLCA3_4; calcium-activated chloride channel regulator 3/4"]
["ENSRNOG00000014021",5,0.415133303,0,0.032165219,12.90627934,3.690001251,0.022406192,0.016171974,"up","yes","Matn4","protein_coding","chr3:153120632-153135865:-","gi|149042955|gb|EDL96529.1|",3211,0,"matrilin 4 (predicted), isoform CRA_a [Rattus norvegicus]","gi|157818268|ref|NM_001106539.1|",2251,0,"Rattus norvegicus matrilin 4 (Matn4), mRNA","O89029",1186,0,"Matrilin-4",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0048678|response to axon injury;","GO:0062023|collagen-containing extracellular matrix;","GO:0005509|calcium ion binding;","K19467","MATN; matrilin"]
["ENSRNOG00000018287",5,0.415133303,0,0.032165219,12.90627934,3.690001251,0.022406192,0.016171974,"up","yes","RGD1307603","protein_coding","chr1:201355682-201358330:-","gi|197384917|ref|NP_001127980.1|",833,{"v":3e-110,"d":"3.00E-110"},"uncharacterized protein LOC293656 [Rattus norvegicus]","gi|197384916|ref|NM_001134508.1|",730,0,"Rattus norvegicus similar to hypothetical protein MGC37914 (RGD1307603), mRNA","P04906",214,{"v":8e-68,"d":"8.00E-68"},"Glutathione S-transferase P",".",".",".",".","pfam02798","GST_N","Glutathione S-transferase, N-terminal domain. Function: conjugation of reduced glutathione to a variety of targets. Also included in the alignment, but are not GSTs: * S-crystallins from squid. Similarity to GST previously noted. * Eukaryotic elongation factors 1-gamma. Not known to have GST activity; similarity not previously recognized. * HSP26 family of stress-related proteins. including auxin-regulated proteins in plants and stringent starvation proteins in Escherichia coli. Not known to have GST activity. Similarity not previously recognized. The glutathione molecule binds in a cleft between N and C-terminal domains - the catalytically important residues are proposed to reside in the N-terminal domain.","GO:0006749|glutathione metabolic process;","GO:0005829|cytosol;","GO:0004364|glutathione transferase activity;","K23790","GSTP; glutathione S-transferase P [EC:2.5.1.18]"]
["ENSRNOG00000020251",5,0.415133303,0,0.032165219,12.90627934,3.690001251,0.022406192,0.016171974,"up","yes","Art1","protein_coding","chr1:156482621-156487172:+","gi|157820191|ref|NP_001101011.1|",1465,0,"GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 precursor [Rattus norvegicus]","gi|158631182|ref|NM_001107541.2|",1369,0,"Rattus norvegicus ADP-ribosyltransferase 1 (Art1), mRNA","Q60935",549,0,"GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1",".",".",".",".","pfam01129","ART","NAD:arginine ADP-ribosyltransferase.","GO:0006471|protein ADP-ribosylation;GO:0018120|peptidyl-arginine ADP-ribosylation;","GO:0009986|cell surface;GO:0031225|anchored component of membrane;","GO:0003950|NAD+ ADP-ribosyltransferase activity;","K06716","ART1, CD296; ADP-ribosyltransferase 1 [EC:2.4.2.31]"]
["ENSRNOG00000020276",5,0.415133303,0,0.032165219,12.90627934,3.690001251,0.022406192,0.016171974,"up","yes","Tnni2","protein_coding","chr1:197594813-197597560:+","gi|355566185|gb|EHH22564.1|",872,{"v":7e-113,"d":"7.00E-113"},"Troponin I, fast-twitch isoform, partial [Macaca mulatta]","gi|298889559|emb|FQ217454.1|",635,0,"Rattus norvegicus TL0ACA25YO07 mRNA sequence","P27768",335,{"v":3e-112,"d":"3.00E-112"},"Troponin I, fast skeletal muscle",".",".",".",".","pfam00992","Troponin","Troponin. Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). this Pfam contains members of the TnT subunit. Troponin is a complex of three proteins, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). The troponin complex regulates Ca++ induced muscle contraction. This family includes troponin T and troponin I. Troponin I binds to actin and troponin T binds to tropomyosin.","GO:0003009|skeletal muscle contraction;GO:0006936|muscle contraction;GO:0006937|regulation of muscle contraction;GO:0045893|positive regulation of transcription, DNA-templated;GO:0060048|cardiac muscle contraction;","GO:0005634|nucleus;GO:0005861|troponin complex;","GO:0003674|molecular_function;GO:0003779|actin binding;GO:0031014|troponin T binding;","K12043","TNNI2; troponin I, fast skeletal muscle"]
["ENSRNOG00000020407",5,0.415133303,0,0.032165219,12.90627934,3.690001251,0.022406192,0.016171974,"up","yes","Atcay","protein_coding","chr7:8487763-8512663:+","gi|93352570|ref|NP_001035280.1|",1851,0,"caytaxin [Rattus norvegicus]","gi|672057807|ref|XR_593257.1|",1731,0,"PREDICTED: Rattus norvegicus ataxia, cerebellar, Cayman type (Atcay), transcript variant X1, misc_RNA","Q1M168",695,0,"Caytaxin",".",".",".",".","pfam12496","BNIP2","Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2. This domain family is found in eukaryotes, and is typically between 119 and 133 amino acids in length. There is a conserved HGGY sequence motif. This family is Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2. It interacts with pro- and anti- apoptotic molecules in the cell.","GO:0006915|apoptotic process;GO:0008150|biological_process;GO:0031175|neuron projection development;GO:0032880|regulation of protein localization;GO:0048311|mitochondrion distribution;GO:2000212|negative regulation of glutamate metabolic process;","GO:0005737|cytoplasm;GO:0030424|axon;GO:0030425|dendrite;GO:0030426|growth cone;GO:0031966|mitochondrial membrane;GO:0043005|neuron projection;GO:0044306|neuron projection terminus;GO:0045202|synapse;GO:0048471|perinuclear region of cytoplasm;GO:0098793|presynapse;","GO:0003674|molecular_function;GO:0019894|kinesin binding;","K18450","ATCAY; caytaxin"]
["ENSRNOG00000025121",5,0.415133303,0,0.032165219,12.90627934,3.690001251,0.022406192,0.016171974,"up","yes","Pla2g3","protein_coding","chr14:78368105-78373913:+","gi|157822409|ref|NP_001099485.1|",1818,0,"group 3 secretory phospholipase A2 precursor [Rattus norvegicus]","gi|157822408|ref|NM_001106015.1|",2478,0,"Rattus norvegicus phospholipase A2, group III (Pla2g3), mRNA","Q9NZ20",417,{"v":2E-169,"d":"2.00E-169"},"Group 3 secretory phospholipase A2",".",".",".",".","pfam05826","Phospholip_A2_2","Phospholipase A2. This family consists of several phospholipase A2 like proteins mostly from insects.","GO:0001675|acrosome assembly;GO:0002532|production of molecular mediator involved in inflammatory response;GO:0006644|phospholipid metabolic process;GO:0006658|phosphatidylserine metabolic process;GO:0007288|sperm axoneme assembly;GO:0010629|negative regulation of gene expression;GO:0010744|positive regulation of macrophage derived foam cell differentiation;GO:0010976|positive regulation of neuron projection development;GO:0019372|lipoxygenase pathway;GO:0031394|positive regulation of prostaglandin biosynthetic process;GO:0032308|positive regulation of prostaglandin secretion;GO:0034374|low-density lipoprotein particle remodeling;GO:0034375|high-density lipoprotein particle remodeling;GO:0042116|macrophage activation;GO:0043303|mast cell degranulation;GO:0043524|negative regulation of neuron apoptotic process;GO:0046337|phosphatidylethanolamine metabolic process;GO:0046470|phosphatidylcholine metabolic process;GO:0046471|phosphatidylglycerol metabolic process;GO:0046473|phosphatidic acid metabolic process;GO:0046488|phosphatidylinositol metabolic process;GO:0048468|cell development;GO:0048469|cell maturation;GO:0050482|arachidonic acid secretion;GO:0060271|cilium assembly;GO:0060376|positive regulation of mast cell differentiation;GO:1900017|positive regulation of cytokine production involved in inflammatory response;GO:1900222|negative regulation of amyloid-beta clearance;GO:1903595|positive regulation of histamine secretion by mast cell;GO:2001135|regulation of endocytic recycling;","GO:0005576|extracellular region;GO:0005814|centriole;GO:0055037|recycling endosome;","GO:0004620|phospholipase activity;GO:0047498|calcium-dependent phospholipase A2 activity;","K01047","PLA2G, SPLA2; secretory phospholipase A2 [EC:3.1.1.4]"]
["ENSRNOG00000027733",5,0.415133303,0,0.032165219,12.90627934,3.690001251,0.022406192,0.016171974,"up","yes","Lair1","protein_coding","chr1:70157681-70185807:+","gi|153945730|ref|NP_001025099.1|",1268,{"v":2e-172,"d":"2.00E-172"},"leukocyte-associated immunoglobulin-like receptor 1 precursor [Rattus norvegicus]","gi|672035182|ref|XM_008758974.1|",1148,0,"PREDICTED: Rattus norvegicus leukocyte-associated immunoglobulin-like receptor 1 (Lair1), transcript variant X1, mRNA","P0C1X9",493,{"v":6e-174,"d":"6.00E-174"},"Leukocyte-associated immunoglobulin-like receptor 1",".",".",".",".","pfam00047","ig","Immunoglobulin domain. Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions. The Pfam alignments do not include the first and last strand of the immunoglobulin-like domain.",".","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;",".","K06725","LAIR, CD305_6; leukocyte-associated Ig-like receptor"]
["ENSRNOG00000035641",5,0.415133303,0,0.032165219,12.90627934,3.690001251,0.022406192,0.016171974,"up","yes","Mir138-1","miRNA","chr8:122300966-122301064:+","gi|594096036|ref|XP_006071288.1|",135,2E-8,"PREDICTED: uncharacterized protein LOC102404169 [Bubalus bubalis]","gi|296923678|ref|NR_031885.1|",99,{"v":2e-43,"d":"2.00E-43"},"Rattus norvegicus microRNA 138-1 (Mir138-1), microRNA",".",".",".",".",".",".",".",".","pfam05147","LANC_like","Lanthionine synthetase C-like protein. Lanthionines are thioether bridges that are putatively generated by dehydration of Ser and Thr residues followed by addition of cysteine residues within the peptide. This family contains the lanthionine synthetase C-like proteins 1 and 2 which are related to the bacterial lanthionine synthetase components C (LanC). LANCL1 (P40 seven-transmembrane-domain protein) and LANCL2 (testes-specific adriamycin sensitivity protein) are thought to be peptide-modifying enzyme components in eukaryotic cells. Both proteins are produced in large quantities in the brain and testes and may have role in the immune surveillance of these organs. Lanthionines are found in lantibiotics, which are peptide-derived, post-translationally modified antimicrobials produced by several bacterial strains. This region contains seven internal repeats.","GO:0042552|myelination;GO:0046660|female sex differentiation;GO:0060291|long-term synaptic potentiation;GO:0071363|cellular response to growth factor stimulus;",".",".",".","."]
["ENSRNOG00000037149",5,0.415133303,0,0.032165219,12.90627934,3.690001251,0.022406192,0.016171974,"up","yes","Bcl2l15","protein_coding","chr2:191338959-191344078:+","gi|157824122|ref|NP_001099929.1|",884,{"v":2e-117,"d":"2.00E-117"},"bcl-2-like protein 15 [Rattus norvegicus]","gi|157824121|ref|NM_001106459.1|",850,0,"Rattus norvegicus BCL2-like 15 (Bcl2l15), mRNA","Q08ED0",268,{"v":7e-89,"d":"7.00E-89"},"Bcl-2-like protein 15",".",".",".",".","pfam00452","Bcl-2","Apoptosis regulator proteins, Bcl-2 family.","GO:0042981|regulation of apoptotic process;","GO:0005634|nucleus;GO:0005829|cytosol;",".",".","."]
["ENSRNOG00000037793",5,0.415133303,0,0.032165219,12.90627934,3.690001251,0.022406192,0.016171974,"up","yes","Cdk5r2","protein_coding","chr9:76416062-76418344:+","gi|524932722|ref|XP_005070542.1|",1228,{"v":3e-159,"d":"3.00E-159"},"PREDICTED: cyclin-dependent kinase 5 activator 2 [Mesocricetus auratus]","gi|145966974|gb|AC139023.15|",1928,0,"Mus musculus chromosome 1, clone RP23-430G15, complete sequence","O35926",470,{"v":8e-158,"d":"8.00E-158"},"Cyclin-dependent kinase 5 activator 2",".",".",".",".","pfam03261","CDK5_activator","Cyclin-dependent kinase 5 activator protein.","GO:0001764|neuron migration;GO:0021549|cerebellum development;GO:0021722|superior olivary nucleus maturation;GO:0021766|hippocampus development;GO:0021819|layer formation in cerebral cortex;GO:0032147|activation of protein kinase activity;GO:0045737|positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045860|positive regulation of protein kinase activity;GO:0045956|positive regulation of calcium ion-dependent exocytosis;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016533|protein kinase 5 complex;GO:0030426|growth cone;GO:0043005|neuron projection;","GO:0003779|actin binding;GO:0061575|cyclin-dependent protein serine/threonine kinase activator activity;","K19929","CDK5R2; cyclin-dependent kinase 5 activator 2"]
["ENSRNOG00000037894",5,0.415133303,0,0.032165219,12.90627934,3.690001251,0.022406192,0.016171974,"up","yes","AABR07068042.1","protein_coding","chr9:73264478-73268630:+","gi|74179767|dbj|BAE22508.1|",357,{"v":1e-40,"d":"1.00E-40"},"unnamed protein product [Mus musculus]","gi|644986914|tpe|HG977898.1|",207,{"v":9E-103,"d":"9.00E-103"},"TPA: Mus musculus long non-coding RNA OTTMUST00000052539.2 (Apol7d gene), antisense",".",".",".",".",".",".",".",".","pfam04735","Baculo_helicase","Baculovirus DNA helicase.",".",".",".",".","."]
["ENSRNOG00000048273",5,0.415133303,0,0.032165219,12.90627934,3.690001251,0.022406192,0.016171974,"up","yes","Apod","protein_coding","chr11:69431260-69452305:+","gi|149060755|gb|EDM11469.1|",948,{"v":2e-126,"d":"2.00E-126"},"apolipoprotein D, isoform CRA_a [Rattus norvegicus]","gi|298912201|emb|FQ212999.1|",838,0,"Rattus norvegicus TL0AAA50YE16 mRNA sequence","P23593",358,{"v":9e-124,"d":"9.00E-124"},"Apolipoprotein D","blc",82,{"v":4e-18,"d":"4.00E-18"},"COG3040","pfam08212","Lipocalin_2","Lipocalin-like domain. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The structure is an eight-stranded beta barrel.","GO:0000302|response to reactive oxygen species;GO:0006006|glucose metabolic process;GO:0006629|lipid metabolic process;GO:0006869|lipid transport;GO:0007420|brain development;GO:0007568|aging;GO:0009410|response to xenobiotic stimulus;GO:0010642|negative regulation of platelet-derived growth factor receptor signaling pathway;GO:0014012|peripheral nervous system axon regeneration;GO:0042246|tissue regeneration;GO:0042308|negative regulation of protein import into nucleus;GO:0048662|negative regulation of smooth muscle cell proliferation;GO:0048678|response to axon injury;GO:0051895|negative regulation of focal adhesion assembly;GO:0060588|negative regulation of lipoprotein lipid oxidation;GO:0071638|negative regulation of monocyte chemotactic protein-1 production;GO:1900016|negative regulation of cytokine production involved in inflammatory response;GO:2000098|negative regulation of smooth muscle cell-matrix adhesion;GO:2000405|negative regulation of T cell migration;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0022626|cytosolic ribosome;GO:0030425|dendrite;GO:0043025|neuronal cell body;GO:0048471|perinuclear region of cytoplasm;","GO:0003674|molecular_function;GO:0015485|cholesterol binding;","K03098","APOD; apolipoprotein D and lipocalin family protein"]
["ENSRNOG00000049017",5,0.415133303,0,0.032165219,12.90627934,3.690001251,0.022406192,0.016171974,"up","yes","Mir6316","miRNA","chr1:256501216-256501316:+",".",".",".",".","gi|563318455|ref|NR_106686.1|",101,{"v":1e-44,"d":"1.00E-44"},"Rattus norvegicus microRNA 6316 (Mir6316), microRNA",".",".",".",".",".",".",".",".","pfam12749","Metallothio_Euk","Eukaryotic metallothionein. This is a family of eukaryotic metallothioneins.",".",".",".",".","."]
["ENSRNOG00000050114",5,0.415133303,0,0.032165219,12.90627934,3.690001251,0.022406192,0.016171974,"up","yes","Fam228a","protein_coding","chr6:27727984-27750061:-","gi|564355283|ref|XP_006239920.1|",1633,0,"PREDICTED: protein FAM228A isoform X1 [Rattus norvegicus]","gi|62078880|ref|NM_001014074.1|",1468,0,"Rattus norvegicus family with sequence similarity 228, member A (Fam228a), mRNA",".",".",".",".",".",".",".",".","pfam07695","7TMR-DISM_7TM","7TM diverse intracellular signalling. This entry represents the transmembrane region of the 7TM-DISM (7TM Receptors with Diverse Intracellular Signalling Modules).",".",".",".",".","."]
["ENSRNOG00000051661",5,0.415133303,0,0.032165219,12.90627934,3.690001251,0.022406192,0.016171974,"up","yes","Ly49s5","protein_coding","chr4:163937898-163960288:-","gi|60678276|ref|NP_001012767.1|",1265,{"v":1e-170,"d":"1.00E-170"},"Ly49 stimulatory receptor 5 [Rattus norvegicus]","gi|60678275|ref|NM_001012749.1|",736,0,"Rattus norvegicus Ly49 stimulatory receptor 5 (Ly49s5), mRNA","Q60652",253,{"v":4E-79,"d":"4.00E-79"},"Killer cell lectin-like receptor 5",".",".",".",".","pfam08391","Ly49","Ly49-like protein, N-terminal region. The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000051729",5,0.415133303,0,0.032165219,12.90627934,3.690001251,0.022406192,0.016171974,"up","yes","U7","snRNA","chr11:76412968-76413034:+",".",".",".",".","gi|62510220|gb|AC112688.10|",47,{"v":8e-15,"d":"8.00E-15"},"Mus musculus chromosome 5, clone RP23-258C13, complete sequence",".",".",".",".",".",".",".",".","pfam03437","BtpA","BtpA family. The BtpA protein is tightly associated with the thylakoid membranes, where it stabilizes the reaction centre proteins of photosystem I.",".",".",".",".","."]
["ENSRNOG00000058260",5,0.415133303,0,0.032165219,12.90627934,3.690001251,0.022406192,0.016171974,"up","yes","Gpbar1","protein_coding","chr9:75860677-75863168:+","gi|29293829|ref|NP_808797.1|",1438,0,"G-protein coupled bile acid receptor 1 [Rattus norvegicus]","gi|672065688|ref|XM_006245235.2|",1325,0,"PREDICTED: Rattus norvegicus G protein-coupled bile acid receptor 1 (Gpbar1), transcript variant X1, mRNA","Q80T02",558,0,"G-protein coupled bile acid receptor 1",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0038184|cell surface bile acid receptor signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:1903413|cellular response to bile acid;GO:1904056|positive regulation of cholangiocyte proliferation;GO:2000810|regulation of bicellular tight junction assembly;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0043235|receptor complex;","GO:0004930|G protein-coupled receptor activity;GO:0038181|bile acid receptor activity;GO:0038182|G protein-coupled bile acid receptor activity;","K08400","GPBAR1; G protein-coupled bile acid receptor 1"]
["ENSRNOG00000058540",5,0.415133303,0,0.032165219,12.90627934,3.690001251,0.022406192,0.016171974,"up","yes","SNORA72","snoRNA","chrX:66278209-66278328:-",".",".",".",".","gi|908663388|tpe|LN872586.1|",102,{"v":5e-45,"d":"5.00E-45"},"TPA: Mus musculus SNORA72 (U72) gene for small nucleolar RNA SNORA72 (U72)",".",".",".",".",".",".",".",".","pfam08004","DUF1699","Protein of unknown function (DUF1699). This family contains many archaeal proteins which have very conserved sequences.",".",".",".",".","."]
["ENSRNOG00000059688",5,0.415133303,0,0.032165219,12.90627934,3.690001251,0.022406192,0.016171974,"up","yes","AABR07030377.1","snoRNA","chr10:80380675-80380818:+",".",".",".",".","gi|224458424|gb|AC110837.5|",80,{"v":1e-32,"d":"1.00E-32"},"Rattus norvegicus CH230-66P5 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam03381","CDC50","LEM3 (ligand-effect modulator 3) family / CDC50 family. Members of this family have been predicted to contain transmembrane helices. The family member LEM3 is a ligand-effect modulator, mutation of which increases glucocorticoid receptor activity in response to dexamethasone and also confers increased activity on other intracellular receptors including the progesterone, oestrogen and mineralocorticoid receptors. LEM3 is thought to affect a downstream step in the glucocorticoid receptor pathway. Factors that modulate ligand responsiveness are likely to contribute to the context-specific actions of the glucocorticoid receptor in mammalian cells. The products of genes YNR048w, YNL323w and YCR094w (CDC50) show redundancy of function and are involved in regulation of transcription via CDC39. CDC39 (also known as NOT1) is normally a negative regulator of transcription either by affecting the general RNA polymerase II machinery or by altering chromatin structure. One function of CDC39 is to block activation of the mating response pathway in the absence of pheromone, and mutation causes arrest in G1 by activation of the pathway. It may be that the cold-sensitive arrest in G1 noticed in CDC50 mutants may be due to inactivation of CDC39. The effects of LEM3 on glucocorticoid receptor activity may also be due to effects on transcription via CDC39.",".",".",".",".","."]
["ENSRNOG00000060020",5,0.415133303,0,0.032165219,12.90627934,3.690001251,0.022406192,0.016171974,"up","yes","C1ql4","protein_coding","chr7:130243606-130246678:-","gi|403420636|ref|NP_001258171.1|",911,{"v":3e-120,"d":"3.00E-120"},"complement C1q-like protein 4 precursor [Rattus norvegicus]","gi|685156907|ref|NM_001271242.2|",879,0,"Rattus norvegicus complement component 1, q subcomponent-like 4 (C1ql4), mRNA","Q4ZJM9",348,{"v":3e-119,"d":"3.00E-119"},"Complement C1q-like protein 4",".",".",".",".","pfam00386","C1q","C1q domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.","GO:0045599|negative regulation of fat cell differentiation;GO:0048147|negative regulation of fibroblast proliferation;GO:0070373|negative regulation of ERK1 and ERK2 cascade;","GO:0005615|extracellular space;","GO:0042802|identical protein binding;","K23284","C1QL; C1q-related factor"]
["ENSRNOG00000062446",5,0.415133303,0,0.032165219,12.90627934,3.690001251,0.022406192,0.016171974,"up","yes","ENSRNOG00000062446","lncRNA","chr2:59942763-59946060:-","gi|37654330|gb|AAQ96270.1|",289,{"v":4e-26,"d":"4.00E-26"},"LRRGT00057 [Rattus norvegicus]","gi|28570530|gb|AC122330.4|",127,{"v":2e-57,"d":"2.00E-57"},"Mus musculus BAC clone RP23-342G7 from chromosome 18, complete sequence","P11369",109,{"v":1E-25,"d":"1.00E-25"},"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam03360","Glyco_transf_43","Glycosyltransferase family 43.",".",".",".",".","."]
["ENSRNOG00000063584",5,0.415133303,0,0.032165219,12.90627934,3.690001251,0.022406192,0.016171974,"up","yes","Rnase1","protein_coding","chr15:24361927-24363624:-","gi|672028444|ref|XP_008766334.1|",744,{"v":1e-96,"d":"1.00E-96"},"PREDICTED: ribonuclease pancreatic beta-type [Rattus norvegicus]","gi|672028443|ref|XM_008768112.1|",786,0,"PREDICTED: Rattus norvegicus ribonuclease pancreatic beta-type (LOC103690354), mRNA","P00684",291,{"v":3E-98,"d":"3.00E-98"},"Ribonuclease pancreatic beta-type",".",".",".",".","pfam00074","RnaseA","Pancreatic ribonuclease. Ribonucleases. Members include pancreatic RNAase A and angiogenins. Structure is an alpha+beta fold -- long curved beta sheet and three helices.",".",".",".",".","."]
["ENSRNOG00000064408",5,0.415133303,0,0.032165219,12.90627934,3.690001251,0.022406192,0.016171974,"up","yes","ENSRNOG00000064408","protein_coding","chr3:155344609-155346445:+",".",".",".",".","gi|354782593|gb|JN947094.1|",377,0,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Prex1:tm1e(KOMP)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.",".",".",".",".","."]
["ENSRNOG00000066039",5,0.415133303,0,0.032165219,12.90627934,3.690001251,0.022406192,0.016171974,"up","yes","ENSRNOG00000066039","protein_coding","chr10:17221938-17223822:+","gi|528767963|gb|EPY87622.1|",128,2e-07,"hypothetical protein CB1_000233026 [Camelus ferus]",".",".",".",".","Q29036",50.4,3e-08,"Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1",".",".",".",".","pfam02109","DAD","DAD family. Members of this family are thought to be integral membrane proteins. Some members of this family have been shown to cause apoptosis if mutated, these proteins are known as DAD for defender against death. The family also includes the epsilon subunit of the oligosaccharyltransferase that is involved in N-linked glycosylation.",".",".",".",".","."]
["ENSRNOG00000066284",5,0.415133303,0,0.032165219,12.90627934,3.690001251,0.022406192,0.016171974,"up","yes","Tmem125","protein_coding","chr5:132059554-132079297:+","gi|157952196|ref|NP_001101437.2|",1129,{"v":3e-137,"d":"3.00E-137"},"transmembrane protein 125 [Rattus norvegicus]","gi|40363256|emb|BX842610.3|",2258,0,"Mouse DNA sequence from clone RP24-16C11 on chromosome 4, complete sequence","Q8CHQ6",207,{"v":3e-58,"d":"3.00E-58"},"Transmembrane protein 125",".",".",".",".","pfam15109","TMEM125","TMEM125 protein family. The function of this family of transmembrane proteins, TMEM125, has not, as yet, been determined. Members of this family are as yet uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 55 and 232 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000066508",5,0.415133303,0,0.032165219,12.90627934,3.690001251,0.022406192,0.016171974,"up","yes","ENSRNOG00000066508","lncRNA","chr1:96556634-96563246:-",".",".",".",".","gi|169235013|gb|AC120807.4|",920,0,"Rattus norvegicus BAC CH230-92D18 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam08695","Coa1","Cytochrome oxidase complex assembly protein 1. Coa1 is an inner mitochondrial membrane protein that associates with Shy1 and is required for cytochrome oxidase complex IV assembly. It contains a conserved hydrophobic segment (amino acids 74-92) with the potential to form a membrane-spanning helix. The N-terminus of Coa1 is rich in positively charged amino acids and could form an amphipathic alpha helix, characteristic of a mitochondrial presequence. A cleavage site for the mitochondrial processing peptidase is predicted adjacent to the presequence. Upon in vitro import into mitochondria, Coa1 is processed to a mature form, indicating that it possesses a cleavable presequence. The eukaryotic cytochrome oxidase complex consists of 12-13 subunits, with three mitochondrial encoded subunits, Cox1-Cox3, forming the core enzyme. Translation of the Cox1 transcript requires the two promoters, Pet309 and Mss51, and the latter has an additional role in translational elongation. Coa1 is necessary for linking the activity of Mss51 to Cox1 insertion into the assembly complex.",".",".",".",".","."]
["ENSRNOG00000067104",5,0.415133303,0,0.032165219,12.90627934,3.690001251,0.022406192,0.016171974,"up","yes","ENSRNOG00000067104","lncRNA","chr4:162679861-162684740:+",".",".",".",".","gi|55700248|gb|AC142191.5|",150,{"v":2E-70,"d":"2.00E-70"},"Mus musculus BAC clone RP24-530N5 from 6, complete sequence",".",".",".",".",".",".",".",".","pfam03098","An_peroxidase","Animal haem peroxidase.",".",".",".",".","."]
["ENSRNOG00000069261",5,0.415133303,0,0.032165219,12.90627934,3.690001251,0.022406192,0.016171974,"up","yes","ENSRNOG00000069261","protein_coding","chr4:70098073-70098533:+","gi|149065381|gb|EDM15457.1|",542,{"v":5e-69,"d":"5.00E-69"},"rCG28259, partial [Rattus norvegicus]","gi|81294329|gb|BC107948.1|",341,{"v":3e-177,"d":"3.00E-177"},"Rattus norvegicus cDNA clone IMAGE:7384620, partial cds",".",".",".",".",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000069347",5,0.415133303,0,0.032165219,12.90627934,3.690001251,0.022406192,0.016171974,"up","yes","ENSRNOG00000069347","lncRNA","chr8:73241794-73244009:+","gi|148694313|gb|EDL26260.1|",247,{"v":6e-23,"d":"6.00E-23"},"mCG1035306, isoform CRA_a [Mus musculus]","gi|354781770|gb|JN946271.1|",92,{"v":2e-38,"d":"2.00E-38"},"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele 4930519F16Rik:tm1a(EUCOMM)Hmgu; transgenic",".",".",".",".",".",".",".",".","pfam01826","TIL","Trypsin Inhibitor like cysteine rich domain. This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.",".",".",".",".","."]
["ENSRNOG00000070730",5,0.415133303,0,0.032165219,12.90627934,3.690001251,0.022406192,0.016171974,"up","yes","ENSRNOG00000070730","snRNA","chr14:3130211-3130333:-",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","pfam11727","ISG65-75","Invariant surface glycoprotein. This family is found in Trypanosome species, and appears to be one of two invariant surface glycoproteins, ISG65 and ISG75. that are found in the mammalian stage of the parasitic protozoan. the sequence suggests the two families are polypeptides with N-terminal signal sequences, hydrophilic extracellular domains, single trans-membrane alpha-helices and short cytoplasmic domains. they are both expressed in the bloodstream form but not in the midgut stage. Both polypeptides are distributed over the entire surface of the parasite.",".",".",".",".","."]
["ENSRNOG00000003998",22,1.826586532,13,0.836295696,2.184139581,1.127065057,0.022552191,0.016267634,"up","yes","Sgca","protein_coding","chr10:79908738-79922813:-","gi|157823585|ref|NP_001100509.1|",1824,0,"alpha-sarcoglycan precursor [Rattus norvegicus]","gi|157823584|ref|NM_001107039.1|",1693,0,"Rattus norvegicus sarcoglycan, alpha (Sgca), mRNA","P82350",691,0,"Alpha-sarcoglycan",".",".",".",".","pfam05510","Sarcoglycan_2","Sarcoglycan alpha/epsilon. Sarcoglycans are a subcomplex of transmembrane proteins which are part of the dystrophin-glycoprotein complex. They are expressed in the skeletal, cardiac and smooth muscle. Although numerous studies have been conducted on the sarcoglycan subcomplex in skeletal and cardiac muscle, the manner of the distribution and localisation of these proteins along the nonjunctional sarcolemma is not clear. This family contains alpha and epsilon members.","GO:0014894|response to denervation involved in regulation of muscle adaptation;GO:0043403|skeletal muscle tissue regeneration;","GO:0005575|cellular_component;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0016011|dystroglycan complex;GO:0016012|sarcoglycan complex;GO:0016021|integral component of membrane;GO:0042383|sarcolemma;GO:0045121|membrane raft;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;","K12565","SGCA; alpha-sarcoglycan"]
["ENSRNOG00000002555",6,0.498159963,1,0.064330438,7.743767604,2.953035657,0.022938118,0.016472227,"up","yes","Serpinb7","protein_coding","chr13:23395671-23442205:+","gi|564380159|ref|XP_006249691.1|",1866,0,"PREDICTED: serpin B7 isoform X1 [Rattus norvegicus]","gi|298908490|emb|FQ228843.1|",1924,0,"Rattus norvegicus TL0ADA51YD11 mRNA sequence","Q9D695",663,0,"Serpin B7","MA2246",168,{"v":6e-45,"d":"6.00E-45"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0010951|negative regulation of endopeptidase activity;GO:0032914|positive regulation of transforming growth factor beta1 production;GO:0032967|positive regulation of collagen biosynthetic process;GO:0072126|positive regulation of glomerular mesangial cell proliferation;GO:0090362|positive regulation of platelet-derived growth factor production;","GO:0005575|cellular_component;GO:0005615|extracellular space;","GO:0003674|molecular_function;GO:0004867|serine-type endopeptidase inhibitor activity;","K13964","SERPINB7; serpin B7"]
["ENSRNOG00000009316",6,0.498159963,1,0.064330438,7.743767604,2.953035657,0.022938118,0.016472227,"up","yes","Bmp10","protein_coding","chr4:119872045-119878627:+","gi|73532772|ref|NP_001026994.1|",2145,0,"bone morphogenetic protein 10 precursor [Rattus norvegicus]","gi|71891582|dbj|AB158418.1|",1266,0,"Rattus norvegicus Bmp10 mRNA for bone morphogenetic protein 10, complete cds, strain:LEC/Crj","Q4AEG6",830,0,"Bone morphogenetic protein 10",".",".",".",".","pfam00019","TGF_beta","Transforming growth factor beta like domain.","GO:0001822|kidney development;GO:0007155|cell adhesion;GO:0007507|heart development;GO:0007512|adult heart development;GO:0010596|negative regulation of endothelial cell migration;GO:0010613|positive regulation of cardiac muscle hypertrophy;GO:0010614|negative regulation of cardiac muscle hypertrophy;GO:0010628|positive regulation of gene expression;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0030308|negative regulation of cell growth;GO:0030336|negative regulation of cell migration;GO:0030509|BMP signaling pathway;GO:0032924|activin receptor signaling pathway;GO:0045214|sarcomere organization;GO:0045893|positive regulation of transcription, DNA-templated;GO:0055009|atrial cardiac muscle tissue morphogenesis;GO:0055010|ventricular cardiac muscle tissue morphogenesis;GO:0055015|ventricular cardiac muscle cell development;GO:0055117|regulation of cardiac muscle contraction;GO:0060038|cardiac muscle cell proliferation;GO:0060045|positive regulation of cardiac muscle cell proliferation;GO:0060298|positive regulation of sarcomere organization;GO:0060347|heart trabecula formation;GO:0060389|pathway-restricted SMAD protein phosphorylation;GO:0060395|SMAD protein signal transduction;GO:0061036|positive regulation of cartilage development;GO:1903242|regulation of cardiac muscle hypertrophy in response to stress;GO:2000138|positive regulation of cell proliferation involved in heart morphogenesis;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0009986|cell surface;GO:0030018|Z disc;","GO:0003674|molecular_function;GO:0005125|cytokine activity;GO:0005179|hormone activity;GO:0008083|growth factor activity;GO:0031433|telethonin binding;GO:0033612|receptor serine/threonine kinase binding;","K22670","BMP10; bone morphogenetic protein 10"]
["ENSRNOG00000010486",6,0.498159963,1,0.064330438,7.743767604,2.953035657,0.022938118,0.016472227,"up","yes","Mpp4","protein_coding","chr9:60569734-60611797:-","gi|158303341|ref|NP_067088.2|",3197,0,"MAGUK p55 subfamily member 4 [Rattus norvegicus]","gi|672065245|ref|XM_006245011.2|",2215,0,"PREDICTED: Rattus norvegicus membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) (Mpp4), transcript variant X1, mRNA","Q6P7F1",1124,0,"MAGUK p55 subfamily member 4","BS_yloD",96.7,{"v":4e-21,"d":"4.00E-21"},"COG0194","pfam00625","Guanylate_kin","Guanylate kinase.","GO:0035418|protein localization to synapse;","GO:0000139|Golgi membrane;GO:0005829|cytosol;GO:0005912|adherens junction;GO:0015629|actin cytoskeleton;GO:0016328|lateral plasma membrane;GO:0032991|protein-containing complex;GO:0042734|presynaptic membrane;GO:0044316|cone cell pedicle;GO:0044317|rod spherule;GO:0045178|basal part of cell;","GO:0005102|signaling receptor binding;","K21109","MPP4; MAGUK p55 subfamily member 4"]
["ENSRNOG00000011145",6,0.498159963,1,0.064330438,7.743767604,2.953035657,0.022938118,0.016472227,"up","yes","Crhr2","protein_coding","chr4:84224002-84265904:-","gi|564347008|ref|XP_006236618.1|",1839,0,"PREDICTED: corticotropin-releasing factor receptor 2 isoform X1 [Rattus norvegicus]","gi|564347011|ref|XM_006236558.1|",1616,0,"PREDICTED: Rattus norvegicus corticotropin releasing hormone receptor 2 (Crhr2), transcript variant X3, mRNA","P47866",710,0,"Corticotropin-releasing factor receptor 2",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0007015|actin filament organization;GO:0007166|cell surface receptor signaling pathway;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007188|adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007205|protein kinase C-activating G protein-coupled receptor signaling pathway;GO:0007631|feeding behavior;GO:0009755|hormone-mediated signaling pathway;GO:0010460|positive regulation of heart rate;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010700|negative regulation of norepinephrine secretion;GO:0014064|positive regulation of serotonin secretion;GO:0016525|negative regulation of angiogenesis;GO:0019233|sensory perception of pain;GO:0021549|cerebellum development;GO:0021854|hypothalamus development;GO:0030855|epithelial cell differentiation;GO:0032755|positive regulation of interleukin-6 production;GO:0032811|negative regulation of epinephrine secretion;GO:0032874|positive regulation of stress-activated MAPK cascade;GO:0033685|negative regulation of luteinizing hormone secretion;GO:0035482|gastric motility;GO:0042423|catecholamine biosynthetic process;GO:0043950|positive regulation of cAMP-mediated signaling;GO:0045777|positive regulation of blood pressure;GO:0046882|negative regulation of follicle-stimulating hormone secretion;GO:0048630|skeletal muscle tissue growth;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0060291|long-term synaptic potentiation;GO:0061179|negative regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:0071376|cellular response to corticotropin-releasing hormone stimulus;GO:0071385|cellular response to glucocorticoid stimulus;GO:0090281|negative regulation of calcium ion import;GO:0106071|positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0106072|negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:2000252|negative regulation of feeding behavior;GO:2000293|negative regulation of defecation;GO:2000573|positive regulation of DNA biosynthetic process;","GO:0005783|endoplasmic reticulum;GO:0005791|rough endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0043025|neuronal cell body;GO:0043196|varicosity;GO:0043204|perikaryon;GO:0043679|axon terminus;GO:0070852|cell body fiber;","GO:0004930|G protein-coupled receptor activity;GO:0005179|hormone activity;GO:0008528|G protein-coupled peptide receptor activity;GO:0015056|corticotrophin-releasing factor receptor activity;GO:0017046|peptide hormone binding;GO:0043404|corticotropin-releasing hormone receptor activity;","K04579","CRHR2; corticotropin releasing hormone receptor 2"]
["ENSRNOG00000014302",6,0.498159963,1,0.064330438,7.743767604,2.953035657,0.022938118,0.016472227,"up","yes","Dlgap3","protein_coding","chr5:139492947-139562625:+","gi|443906724|ref|NP_775161.2|",3631,0,"disks large-associated protein 3 isoform 1 [Rattus norvegicus]","gi|688955213|ref|NM_173138.4|",3751,0,"Rattus norvegicus discs large homolog associated protein 3 (Dlgap3), transcript variant 1, mRNA","Q6PFD5",1401,0,"Disks large-associated protein 3",".",".",".",".","pfam03359","GKAP","Guanylate-kinase-associated protein (GKAP) protein.","GO:0023052|signaling;GO:0065003|protein-containing complex assembly;GO:0098962|regulation of postsynaptic neurotransmitter receptor activity;GO:0099563|modification of synaptic structure;","GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0031594|neuromuscular junction;GO:0043025|neuronal cell body;GO:0043197|dendritic spine;GO:0045202|synapse;GO:0098978|glutamatergic synapse;GO:0098981|cholinergic synapse;GO:0099572|postsynaptic specialization;","GO:0001540|amyloid-beta binding;GO:0005515|protein binding;GO:0019904|protein domain specific binding;GO:0030165|PDZ domain binding;GO:0060090|molecular adaptor activity;GO:0097110|scaffold protein binding;",".","."]
["ENSRNOG00000021851",6,0.498159963,1,0.064330438,7.743767604,2.953035657,0.022938118,0.016472227,"up","yes","Ccl1","protein_coding","chr10:67128331-67131159:-","gi|300797687|ref|NP_001178021.1|",482,{"v":2e-59,"d":"2.00E-59"},"C-C motif chemokine 1 precursor [Rattus norvegicus]","gi|300797686|ref|NM_001191092.1|",452,0,"Rattus norvegicus chemokine (C-C motif) ligand 1 (Ccl1), mRNA","P10146",129,{"v":6E-37,"d":"6.00E-37"},"C-C motif chemokine 1",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0002548|monocyte chemotaxis;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0030593|neutrophil chemotaxis;GO:0031640|killing of cells of other organism;GO:0032740|positive regulation of interleukin-17 production;GO:0043547|positive regulation of GTPase activity;GO:0048245|eosinophil chemotaxis;GO:0048247|lymphocyte chemotaxis;GO:0050729|positive regulation of inflammatory response;GO:0051384|response to glucocorticoid;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098|chemokine-mediated signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0090026|positive regulation of monocyte chemotaxis;","GO:0005575|cellular_component;GO:0005615|extracellular space;","GO:0003674|molecular_function;GO:0005125|cytokine activity;GO:0008009|chemokine activity;GO:0048020|CCR chemokine receptor binding;","K05514","CCL1; C-C motif chemokine 1"]
["ENSRNOG00000028812",6,0.498159963,1,0.064330438,7.743767604,2.953035657,0.022938118,0.016472227,"up","yes","Trim80","protein_coding","chr10:100682830-100691151:+","gi|672025448|ref|XP_008773771.1|",3197,0,"PREDICTED: E3 ubiquitin/ISG15 ligase TRIM25 [Rattus norvegicus]","gi|672025447|ref|XM_008775549.1|",1984,0,"PREDICTED: Rattus norvegicus tripartite motif protein 47-like (Trim47l), mRNA","Q8C0E3",204,{"v":3e-55,"d":"3.00E-55"},"Tripartite motif-containing protein 47",".",".",".",".","pfam15227","zf-C3HC4_4","zinc finger of C3HC4-type, RING. This is a family of primate-specific Ret finger protein-like (RFPL) zinc-fingers of the C3HC4 type. Ret finger protein-like proteins are primate-specific target genes of Pax6, a key transcription factor for pancreas, eye and neocortex development. This domain is likely to be DNA-binding. This zinc-finger domain together with the RDM domain, pfam11002, forms a large zinc-finger structure of the RING/U-Box superfamily. RING-containing proteins are known to exert an E3 ubiquitin protein ligase activity with the zinc-finger structure being mandatory for binding to the E2 ubiquitin-conjugating enzyme.",".",".","GO:0008270|zinc ion binding;","K12023","TRIM47; tripartite motif-containing protein 47"]
["ENSRNOG00000029459",6,0.498159963,1,0.064330438,7.743767604,2.953035657,0.022938118,0.016472227,"up","yes","AABR07021591.1","protein_coding","chr13:74582858-74583313:+","gi|51890509|dbj|BAD42838.1|",694,{"v":6e-91,"d":"6.00E-91"},"hypothetical protein [Mus musculus]","gi|311213901|ref|NR_002870.2|",383,0,"Mus musculus dynamin 3, opposite strand (Dnm3os), long non-coding RNA",".",".",".",".",".",".",".",".","pfam15242","FAM53","Family of FAM53. The FAM53 protein family refers to a family of proteins, which bind to a transcriptional regulator that modulates cell proliferation. It is known to be highly important in neural tube development. It is found in eukaryotes and is typically between 303 and 413 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000031703",6,0.498159963,1,0.064330438,7.743767604,2.953035657,0.022938118,0.016472227,"up","yes","AABR07071294.1","protein_coding","chr8:100574894-100575268:-","gi|829902827|ref|XP_012591197.1|",376,{"v":1e-43,"d":"1.00E-43"},"PREDICTED: 40S ribosomal protein S25-like, partial [Microcebus murinus]","gi|298904423|emb|FQ221873.1|",335,{"v":6e-174,"d":"6.00E-174"},"Rattus norvegicus TL0ADA30YK23 mRNA sequence","Q6Q311",147,{"v":2e-44,"d":"2.00E-44"},"40S ribosomal protein S25","YGR027c",76.6,{"v":8e-18,"d":"8.00E-18"},"COG4901","pfam03297","Ribosomal_S25","S25 ribosomal protein.",".",".",".",".","."]
["ENSRNOG00000036690",6,0.498159963,1,0.064330438,7.743767604,2.953035657,0.022938118,0.016472227,"up","yes","Ppp1r27","protein_coding","chr10:105828364-105829533:-","gi|148702817|gb|EDL34764.1|",726,{"v":1e-93,"d":"1.00E-93"},"mCG144859, partial [Mus musculus]","gi|157786725|ref|NM_001105858.1|",789,0,"Rattus norvegicus protein phosphatase 1, regulatory subunit 27 (Ppp1r27), mRNA","Q9D119",258,{"v":2E-85,"d":"2.00E-85"},"Protein phosphatase 1 regulatory subunit 27","all2748",56.2,3e-08,"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).",".",".","GO:0019902|phosphatase binding;","K17566","PPP1R27; protein phosphatase 1 regulatory subunit 27"]
["ENSRNOG00000049821",6,0.498159963,1,0.064330438,7.743767604,2.953035657,0.022938118,0.016472227,"up","yes","RGD1564380","protein_coding","chr1:80273019-80278219:-","gi|281371406|ref|NP_001163800.1|",1029,{"v":2E-136,"d":"2.00E-136"},"uncharacterized protein LOC292711 precursor [Rattus norvegicus]","gi|672034996|ref|XM_006228544.2|",1143,0,"PREDICTED: Rattus norvegicus similar to BC049730 protein (RGD1564380), transcript variant X5, mRNA","Q8N6Q3",102,{"v":1E-22,"d":"1.00E-22"},"CD177 antigen",".",".",".",".","pfam00021","UPAR_LY6","u-PAR/Ly-6 domain. This extracellular disulphide bond rich domain is related to pfam00087.","GO:0007159|leukocyte cell-cell adhesion;GO:0043315|positive regulation of neutrophil degranulation;GO:0045217|cell-cell junction maintenance;GO:0098742|cell-cell adhesion via plasma-membrane adhesion molecules;GO:2001044|regulation of integrin-mediated signaling pathway;","GO:0044853|plasma membrane raft;GO:0046658|anchored component of plasma membrane;",".",".","."]
["ENSRNOG00000049929",6,0.498159963,1,0.064330438,7.743767604,2.953035657,0.022938118,0.016472227,"up","yes","AABR07030494.1","protein_coding","chr10:87574943-87575317:-","gi|6753144|ref|NP_033859.1|",497,{"v":2e-61,"d":"2.00E-61"},"V-type proton ATPase 16 kDa proteolipid subunit [Mus musculus]","gi|564370832|ref|XM_006245898.1|",317,{"v":6e-164,"d":"6.00E-164"},"PREDICTED: Rattus norvegicus ATPase, H+ transporting, lysosomal V0 subunit C (Atp6v0c), transcript variant X1, mRNA","P63081",196,{"v":5e-63,"d":"5.00E-63"},"V-type proton ATPase 16 kDa proteolipid subunit","SPAC1B3.14",151,{"v":5e-46,"d":"5.00E-46"},"COG0636","pfam00137","ATP-synt_C","ATP synthase subunit C.",".",".",".",".","."]
["ENSRNOG00000056815",6,0.498159963,1,0.064330438,7.743767604,2.953035657,0.022938118,0.016472227,"up","yes","AABR07032623.1","snoRNA","chr18:71213119-71213246:+",".",".",".",".","gi|908662265|tpe|LN871987.1|",63,{"v":3E-23,"d":"3.00E-23"},"TPA: Mus musculus SNORA17 (ACA17) gene for small nucleolar RNA SNORA17 (ACA17)",".",".",".",".",".",".",".",".","pfam08325","WLM","WLM domain. This is a predicted metallopeptidase domain called WLM (Wss1p-like metalloproteases). These are linked to the Ub-system by virtue of fusions with the UB-binding PUG (PUB), Ub-like, and Little Finger domains. More specifically, genetic evidence implicates the WLM family in de-SUMOylation.",".",".",".",".","."]
["ENSRNOG00000057848",6,0.498159963,1,0.064330438,7.743767604,2.953035657,0.022938118,0.016472227,"up","yes","Cacng8","protein_coding","chr1:65755334-65779089:-","gi|21687018|ref|NP_542427.1|",1578,0,"voltage-dependent calcium channel gamma-8 subunit [Rattus norvegicus]","gi|953768335|ref|NM_133190.2|",1277,0,"Mus musculus calcium channel, voltage-dependent, gamma subunit 8 (Cacng8), mRNA","Q8VHW5",612,0,"Voltage-dependent calcium channel gamma-8 subunit",".",".",".",".","pfam00822","PMP22_Claudin","PMP-22/EMP/MP20/Claudin family.","GO:0019226|transmission of nerve impulse;GO:0051968|positive regulation of synaptic transmission, glutamatergic;GO:0070588|calcium ion transmembrane transport;GO:0098943|neurotransmitter receptor transport, postsynaptic endosome to lysosome;GO:0098970|postsynaptic neurotransmitter receptor diffusion trapping;GO:0099072|regulation of postsynaptic membrane neurotransmitter receptor levels;GO:0099590|neurotransmitter receptor internalization;GO:2000311|regulation of AMPA receptor activity;GO:2000969|positive regulation of AMPA receptor activity;","GO:0014069|postsynaptic density;GO:0016021|integral component of membrane;GO:0032281|AMPA glutamate receptor complex;GO:0032590|dendrite membrane;GO:0045211|postsynaptic membrane;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098839|postsynaptic density membrane;GO:0098978|glutamatergic synapse;GO:0099061|integral component of postsynaptic density membrane;GO:1990454|L-type voltage-gated calcium channel complex;","GO:0005244|voltage-gated ion channel activity;GO:0005245|voltage-gated calcium channel activity;GO:0005246|calcium channel regulator activity;GO:0005262|calcium channel activity;GO:0005515|protein binding;GO:0016247|channel regulator activity;GO:0030346|protein phosphatase 2B binding;GO:0035255|ionotropic glutamate receptor binding;","K04873","CACNG8; voltage-dependent calcium channel gamma-8"]
["ENSRNOG00000062454",6,0.498159963,1,0.064330438,7.743767604,2.953035657,0.022938118,0.016472227,"up","yes","ENSRNOG00000062454","protein_coding","chrX:121403649-122290207:-","gi|7657413|ref|NP_035985.2|",14130,0,"teneurin-1 [Mus musculus]","gi|755564930|ref|XM_011251006.1|",8432,0,"PREDICTED: Mus musculus teneurin transmembrane protein 1 (Tenm1), transcript variant X2, mRNA","Q9WTS4",5447,0,"Teneurin-1",".",".",".",".","pfam06484","Ten_N","Teneurin Intracellular Region. This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).",".",".",".",".","."]
["ENSRNOG00000063123",6,0.498159963,1,0.064330438,7.743767604,2.953035657,0.022938118,0.016472227,"up","yes","ENSRNOG00000063123","lncRNA","chr9:84125192-84130338:+","gi|148701441|gb|EDL33388.1|",201,{"v":3e-15,"d":"3.00E-15"},"mCG1045525, partial [Mus musculus]","gi|51592284|gb|AC125444.9|",283,{"v":4e-144,"d":"4.00E-144"},"Mus musculus chromosome 1, clone RP24-499L20, complete sequence","Q2TA45",48.5,6E-9,"Arf-GAP domain and FG repeat-containing protein 1",".",".",".",".","pfam01412","ArfGap","Putative GTPase activating protein for Arf. Putative zinc fingers with GTPase activating proteins (GAPs) towards the small GTPase, Arf. The GAP of ARD1 stimulates GTPase hydrolysis for ARD1 but not ARFs.",".",".",".",".","."]
["ENSRNOG00000064692",6,0.498159963,1,0.064330438,7.743767604,2.953035657,0.022938118,0.016472227,"up","yes","Kif4b","protein_coding","chr6:120397005-120401245:+","gi|564307666|ref|XP_006225924.1|",5834,0,"PREDICTED: chromosome-associated kinesin KIF4A-like isoform X1 [Rattus norvegicus]","gi|672021055|ref|XM_006225862.2|",4145,0,"PREDICTED: Rattus norvegicus kinesin family member 4B (Kif4b), transcript variant X1, mRNA","O95239",1639,0,"Chromosome-associated kinesin KIF4A",".",".",".",".","pfam00225","Kinesin","Kinesin motor domain.",".",".",".",".","."]
["ENSRNOG00000066124",6,0.498159963,1,0.064330438,7.743767604,2.953035657,0.022938118,0.016472227,"up","yes","ENSRNOG00000066124","lncRNA","chr6:41463351-41471033:-","gi|672056003|ref|XP_008762861.1|",774,{"v":5e-92,"d":"5.00E-92"},"PREDICTED: skin secretory protein xP2-like [Rattus norvegicus]","gi|31193858|gb|AC131631.5|",1084,0,"Rattus norvegicus 2 BAC CH230-16C23 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam15498","Dendrin","Nephrin and CD2AP-binding protein, Dendrin. Dendrin is a family of eukaryotic proteins found in the podocytes of the kidneys. Dendrin, originally identified in telencephalic dendrites, is a constituent of the slit diaphragm, SD, complex of podocytes, where it directly binds to nephrin and CD2AP. Kidney podocytes and their slit diaphragms (SDs) form the final barrier to urinary protein loss. SD proteins also participate in intracellular signalling pathways. Dendrin appears to prevent programmed cell death (apoptosis) through its binding to nephrin. The SD protein nephrin serves as a component of a signalling complex that directly links podocyte junctional integrity to actin cytoskeletal dynamics. Thus, dendrin is identified as an SD family with proapoptotic signalling properties that accumulates in the podocyte nucleus in response to glomerular injury.",".",".",".",".","."]
["ENSRNOG00000066538",6,0.498159963,1,0.064330438,7.743767604,2.953035657,0.022938118,0.016472227,"up","yes","ENSRNOG00000066538","protein_coding","chr15:27170628-27197907:+","gi|149063817|gb|EDM14087.1|",519,{"v":6E-65,"d":"6.00E-65"},"rCG64477, partial [Rattus norvegicus]","gi|672077936|ref|XR_596105.1|",289,{"v":2e-148,"d":"2.00E-148"},"PREDICTED: Rattus norvegicus uncharacterized LOC103693831 (LOC103693831), ncRNA","A0A075B6W5",127,{"v":2e-36,"d":"2.00E-36"},"T cell receptor alpha variable 23/delta variable 6",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000066578",6,0.498159963,1,0.064330438,7.743767604,2.953035657,0.022938118,0.016472227,"up","yes","ENSRNOG00000066578","lncRNA","chr15:18211264-18216896:+",".",".",".",".","gi|672077675|ref|XM_006251786.2|",167,{"v":2e-80,"d":"2.00E-80"},"PREDICTED: Rattus norvegicus prostaglandin E receptor 2 (subtype EP2) (Ptger2), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam11842","DUF3362","Domain of unknown function (DUF3362). This domain is functionally uncharacterized. This domain is found in bacteria and archaea. This presumed domain is typically between 117 to 158 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000069235",6,0.498159963,1,0.064330438,7.743767604,2.953035657,0.022938118,0.016472227,"up","yes","ENSRNOG00000069235","lncRNA","chr4:17340175-17345542:-",".",".",".",".","gi|63988083|gb|AC154124.5|",691,0,"Mus musculus chromosome 5, clone RP24-63G13, complete sequence",".",".",".",".",".",".",".",".","pfam14897","EpsG","EpsG family. This family of proteins are related to the EpsG protein from B. subtilis. These proteins are likely glycosyl transferases belonging to the membrane protein GT-C clan.",".",".",".",".","."]
["ENSRNOG00000069412",6,0.498159963,1,0.064330438,7.743767604,2.953035657,0.022938118,0.016472227,"up","yes","ENSRNOG00000069412","protein_coding","chr14:65774228-65774657:-","gi|194381880|dbj|BAG64309.1|",326,{"v":5E-36,"d":"5.00E-36"},"unnamed protein product [Homo sapiens]","gi|164689261|dbj|AK309274.1|",184,{"v":4E-90,"d":"4.00E-90"},"Homo sapiens cDNA, FLJ99315","A5A6N4",131,{"v":5E-36,"d":"5.00E-36"},"Eukaryotic initiation factor 4A-I","SPAC1006.07",79.7,{"v":1e-21,"d":"1.00E-21"},"COG0513","pfam09724","DUF2036","Uncharacterized conserved protein (DUF2036). This family of proteins includes members ranging in size from approximately 300 to 460 residues. There are a number of well-conserved domains along the length.",".",".",".",".","."]
["ENSRNOG00000069440",6,0.498159963,1,0.064330438,7.743767604,2.953035657,0.022938118,0.016472227,"up","yes","ENSRNOG00000069440","lncRNA","chr1:79777945-79799580:-","gi|149058973|gb|EDM09980.1|",123,1e-09,"rCG44489, partial [Rattus norvegicus]","gi|388240416|dbj|AP012456.1|",158,{"v":3e-75,"d":"3.00E-75"},"Rattus norvegicus DNA, BAC clone: RNB1-385K15, strain: F344/Stm, complete sequence",".",".",".",".",".",".",".",".","pfam00429","TLV_coat","ENV polyprotein (coat polyprotein).",".",".",".",".","."]
["ENSRNOG00000069964",6,0.498159963,1,0.064330438,7.743767604,2.953035657,0.022938118,0.016472227,"up","yes","ENSRNOG00000069964","lncRNA","chr4:119837519-119842865:+",".",".",".",".","gi|564304006|ref|XR_345945.1|",2319,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102554941 (LOC102554941), ncRNA",".",".",".",".",".",".",".",".","pfam14648","FAM91_C","FAM91 C-terminus.",".",".",".",".","."]
["ENSRNOG00000070190",6,0.498159963,1,0.064330438,7.743767604,2.953035657,0.022938118,0.016472227,"up","yes","Cd300lb","protein_coding","chr10:99964801-99974790:-","gi|264681503|ref|NP_001161136.1|",1100,{"v":2E-150,"d":"2.00E-150"},"CMRF35-like molecule 7 precursor [Rattus norvegicus]","gi|264681502|ref|NM_001167664.1|",669,0,"Rattus norvegicus CD300 molecule-like family member b (Cd300lb), mRNA","Q3U497",374,{"v":2e-130,"d":"2.00E-130"},"CMRF35-like molecule 7",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000070462",6,0.498159963,1,0.064330438,7.743767604,2.953035657,0.022938118,0.016472227,"up","yes","Hist1h2ac","protein_coding","chr17:42478860-42479252:+","gi|671000624|ref|XP_008691171.1|",548,{"v":2e-69,"d":"2.00E-69"},"PREDICTED: histone H2A type 1-like [Ursus maritimus]","gi|672082113|ref|XM_003751712.3|",393,0,"PREDICTED: Rattus norvegicus histone cluster 1, H2ac (Hist1h2ac), mRNA","C0HKE9",215,{"v":8e-71,"d":"8.00E-71"},"Histone H2A type 1-P","SPAC19G12.06c",179,{"v":4e-57,"d":"4.00E-57"},"COG5262","pfam00125","Histone","Core histone H2A/H2B/H3/H4.",".",".",".",".","."]
["ENSRNOG00000010162",16,1.328426568,8,0.514643505,2.581255868,1.368073156,0.02353949,0.016864567,"up","yes","Tex38","protein_coding","chr5:129261552-129264673:-","gi|564352464|ref|XP_006238780.1|",1044,{"v":1e-140,"d":"1.00E-140"},"PREDICTED: testis-expressed sequence 38 protein isoform X1 [Rattus norvegicus]","gi|672053569|ref|XM_006238718.2|",888,0,"PREDICTED: Rattus norvegicus testis expressed 38 (Tex38), transcript variant X1, mRNA","A2A8T7",345,{"v":4e-118,"d":"4.00E-118"},"Testis-expressed protein 38",".",".",".",".","pfam04780","DUF629","Protein of unknown function (DUF629). This family represents a region of several plant proteins of unknown function. A C2H2 zinc finger is predicted in this region in some family members, but the spacing between the cysteine residues is not conserved throughout the family.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000016872",16,1.328426568,8,0.514643505,2.581255868,1.368073156,0.02353949,0.016864567,"up","yes","Plppr4","protein_coding","chr2:205371322-205412302:-","gi|325197225|ref|NP_001001508.2|",3612,0,"phospholipid phosphatase-related protein type 4 [Rattus norvegicus]","gi|325197224|ref|NM_001001508.2|",4736,0,"Rattus norvegicus phospholipid phosphatase related 4 (Plppr4), mRNA","Q7TME0",1390,0,"Phospholipid phosphatase-related protein type 4",".",".",".",".","pfam01569","PAP2","PAP2 superfamily. This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidizing halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.","GO:0006644|phospholipid metabolic process;GO:0007165|signal transduction;GO:0007409|axonogenesis;GO:0046839|phospholipid dephosphorylation;GO:0048839|inner ear development;","GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0098978|glutamatergic synapse;GO:0099061|integral component of postsynaptic density membrane;","GO:0008195|phosphatidate phosphatase activity;GO:0042577|lipid phosphatase activity;GO:0052642|lysophosphatidic acid phosphatase activity;","K19582","LPPR3_4; lipid phosphate phosphatase-related protein type 3/4"]
["ENSRNOG00000034031",16,1.328426568,8,0.514643505,2.581255868,1.368073156,0.02353949,0.016864567,"up","yes","Vstm2l","protein_coding","chr3:146571278-146600325:+","gi|524965621|ref|XP_005082716.1|",872,{"v":2E-116,"d":"2.00E-116"},"PREDICTED: V-set and transmembrane domain-containing protein 2-like protein [Mesocricetus auratus]","gi|672047859|ref|XM_342561.7|",609,0,"PREDICTED: Rattus norvegicus V-set and transmembrane domain containing 2 like (Vstm2l), transcript variant X3, mRNA","Q96N03",318,{"v":3e-109,"d":"3.00E-109"},"V-set and transmembrane domain-containing protein 2-like protein",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0043524|negative regulation of neuron apoptotic process;","GO:0005576|extracellular region;GO:0005737|cytoplasm;",".",".","."]
["ENSRNOG00000063278",16,1.328426568,8,0.514643505,2.581255868,1.368073156,0.02353949,0.016864567,"up","yes","ENSRNOG00000063278","protein_coding","chrX:117620634-117621287:-","gi|531171|gb|AAA86463.1|",999,{"v":3e-135,"d":"3.00E-135"},"Csa-19 [Homo sapiens]","gi|37231658|gb|BC058468.1|",618,0,"Rattus norvegicus ribosomal protein L10A, mRNA (cDNA clone MGC:72800 IMAGE:6919792), complete cds","P62907",389,{"v":1E-136,"d":"1.00E-136"},"60S ribosomal protein L10a","SPCC1183.08c",251,{"v":7e-83,"d":"7.00E-83"},"COG0081","pfam00687","Ribosomal_L1","Ribosomal protein L1p/L10e family. This family includes prokaryotic L1 and eukaryotic L10.",".",".",".",".","."]
["ENSRNOG00000012040",23,1.909613192,14,0.900626135,2.12031732,1.08428019,0.023798711,0.017025221,"up","yes","Slc25a48","protein_coding","chr17:8121175-8160748:-","gi|672081049|ref|XP_008769695.1|",1613,0,"PREDICTED: solute carrier family 25 member 48 isoform X2 [Rattus norvegicus]","gi|672081048|ref|XM_008771473.1|",1851,0,"PREDICTED: Rattus norvegicus solute carrier family 25, member 48 (Slc25a48), transcript variant X4, mRNA","Q8BW66",591,0,"Solute carrier family 25 member 48",".",".",".",".","pfam00153","Mito_carr","Mitochondrial carrier protein.","GO:0006844|acyl carnitine transport;GO:0006865|amino acid transport;GO:1902616|acyl carnitine transmembrane transport;","GO:0016021|integral component of membrane;","GO:0015227|acyl carnitine transmembrane transporter activity;","K15124","SLC25A48; solute carrier family 25, member 48"]
["ENSRNOG00000019306",23,1.909613192,14,0.900626135,2.12031732,1.08428019,0.023798711,0.017025221,"up","yes","Syt12","protein_coding","chr1:201730371-201759609:-","gi|20301966|ref|NP_620190.1|",2058,0,"synaptotagmin-12 [Rattus norvegicus]","gi|20301965|ref|NM_138835.1|",2057,0,"Rattus norvegicus synaptotagmin 12 (Syt12), mRNA","P97610",797,0,"Synaptotagmin-12",".",".",".",".","pfam00168","C2","C2 domain.","GO:0014059|regulation of dopamine secretion;GO:0016192|vesicle-mediated transport;GO:0017156|calcium ion regulated exocytosis;GO:0017158|regulation of calcium ion-dependent exocytosis;GO:0046928|regulation of neurotransmitter secretion;GO:0048792|spontaneous exocytosis of neurotransmitter;GO:0060291|long-term synaptic potentiation;GO:0071277|cellular response to calcium ion;","GO:0005886|plasma membrane;GO:0008021|synaptic vesicle;GO:0016021|integral component of membrane;GO:0030672|synaptic vesicle membrane;GO:0070382|exocytic vesicle;GO:0098686|hippocampal mossy fiber to CA3 synapse;GO:0098793|presynapse;","GO:0000149|SNARE binding;GO:0001786|phosphatidylserine binding;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0005544|calcium-dependent phospholipid binding;GO:0019905|syntaxin binding;GO:0030276|clathrin binding;","K19912","SYT12; synaptotagmin-12"]
["ENSRNOG00000067318",23,1.909613192,14,0.900626135,2.12031732,1.08428019,0.023798711,0.017025221,"up","yes","ENSRNOG00000067318","lncRNA","chr1:46061332-46069072:-","gi|537234786|gb|ERE84951.1|",202,{"v":7e-14,"d":"7.00E-14"},"putative UPF0463 transmembrane protein C6orf35 like protein [Cricetulus griseus]","gi|82177620|gb|AC163715.5|",898,0,"Mus musculus BAC clone RP23-367H6 from chromosome 17, complete sequence",".",".",".",".",".",".",".",".","pfam04929","Herpes_DNAp_acc","Herpes DNA replication accessory factor. Replicative DNA polymerases are capable of polymerising tens of thousands of nucleotides without dissociating from their DNA templates. The high processivity of these polymerases is dependent upon accessory proteins that bind to the catalytic subunit of the polymerase or to the substrate. The Epstein-Barr virus (EBV) BMRF1 protein is an essential component of the viral DNA polymerase and is absolutely required for lytic virus replication. BMRF1 is also a transactivator. This family is predicted to have a UL42 like structure.",".",".",".",".","."]
["ENSRNOG00000002978",24,1.992639853,15,0.964956573,2.065004694,1.046145061,0.024926455,0.017738714,"up","yes","Faslg","protein_coding","chr13:74154954-74162215:-","gi|6978525|ref|NP_037040.1|",1255,{"v":9e-168,"d":"9.00E-168"},"tumor necrosis factor ligand superfamily member 6 [Rattus norvegicus]","gi|672074300|ref|XM_008769607.1|",1623,0,"PREDICTED: Rattus norvegicus Fas ligand (TNF superfamily, member 6) (Faslg), transcript variant X2, mRNA","P36940",488,{"v":3e-169,"d":"3.00E-169"},"Tumor necrosis factor ligand superfamily member 6",".",".",".",".","pfam00229","TNF","TNF(tumor Necrosis Factor) family.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006925|inflammatory cell apoptotic process;GO:0008284|positive regulation of cell proliferation;GO:0008625|extrinsic apoptotic signaling pathway via death domain receptors;GO:0016525|negative regulation of angiogenesis;GO:0030644|cellular chloride ion homeostasis;GO:0032496|response to lipopolysaccharide;GO:0043065|positive regulation of apoptotic process;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043525|positive regulation of neuron apoptotic process;GO:0045742|positive regulation of epidermal growth factor receptor signaling pathway;GO:0046666|retinal cell programmed cell death;GO:0048388|endosomal lumen acidification;GO:0070231|T cell apoptotic process;GO:0070266|necroptotic process;GO:0070848|response to growth factor;GO:0071346|cellular response to interferon-gamma;GO:0097190|apoptotic signaling pathway;GO:0097191|extrinsic apoptotic signaling pathway;GO:0097527|necroptotic signaling pathway;GO:1903514|release of sequestered calcium ion into cytosol by endoplasmic reticulum;GO:1905782|positive regulation of phosphatidylserine exposure on apoptotic cell surface;GO:2000353|positive regulation of endothelial cell apoptotic process;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0005901|caveola;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0031410|cytoplasmic vesicle;GO:0043202|lysosomal lumen;GO:0045121|membrane raft;GO:0048471|perinuclear region of cytoplasm;GO:0060205|cytoplasmic vesicle lumen;GO:0070062|extracellular exosome;","GO:0005123|death receptor binding;GO:0005125|cytokine activity;GO:0005164|tumor necrosis factor receptor binding;","K04389","TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6"]
["ENSRNOG00000037310",12,0.996319926,5,0.321652191,3.097507041,1.631107562,0.025479741,0.018098213,"up","yes","Riiad1","protein_coding","chr2:182101795-182110319:-","gi|564337636|ref|XP_006232909.1|",506,{"v":2e-61,"d":"2.00E-61"},"PREDICTED: RIIa domain-containing protein 1 isoform X1 [Rattus norvegicus]","gi|222352152|ref|NM_001144957.1|",447,0,"Rattus norvegicus regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 (Riiad1), mRNA",".",".",".",".",".",".",".",".","pfam15058","Speriolin_N","Speriolin N terminus. This family represents the N-terminus of the sperm centrosome protein speriolin.",".",".",".",".","."]
["ENSRNOG00000047125",12,0.996319926,5,0.321652191,3.097507041,1.631107562,0.025479741,0.018098213,"up","yes","Foxl1","protein_coding","chr19:49197400-49198425:+","gi|564321597|ref|XP_006222839.1|",1354,0,"PREDICTED: forkhead box protein L1 [Rattus norvegicus]","gi|672031372|ref|XM_006222777.2|",1026,0,"PREDICTED: Rattus norvegicus similar to Forkhead box protein L1 (Forkhead-related protein FKHL11) (Transcription factor FKH-6) (LOC687553), mRNA","Q64731",463,{"v":5e-162,"d":"5.00E-162"},"Forkhead box protein L1","SPBC4C3.05",102,{"v":8e-23,"d":"8.00E-23"},"COG5025","pfam00250","Fork_head","Fork head domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0007495|visceral mesoderm-endoderm interaction involved in midgut development;GO:0007507|heart development;GO:0009653|anatomical structure morphogenesis;GO:0030111|regulation of Wnt signaling pathway;GO:0030154|cell differentiation;GO:0030166|proteoglycan biosynthetic process;GO:0061146|Peyer's patch morphogenesis;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0043565|sequence-specific DNA binding;","K09405","FOXL; forkhead box protein L"]
["ENSRNOG00000056323",12,0.996319926,5,0.321652191,3.097507041,1.631107562,0.025479741,0.018098213,"up","yes","Gm27991","snoRNA","chr6:138832134-138832273:-","gi|556719835|ref|XP_005955798.1|",173,{"v":2E-14,"d":"2.00E-14"},"PREDICTED: 60S ribosomal protein L32 isoform X1 [Pantholops hodgsonii]","gi|256985238|gb|AC118412.6|",140,{"v":5e-66,"d":"5.00E-66"},"Rattus norvegicus CH230-221E17 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam01086","Clathrin_lg_ch","Clathrin light chain.",".",".",".",".","."]
["ENSRNOG00000065967",12,0.996319926,5,0.321652191,3.097507041,1.631107562,0.025479741,0.018098213,"up","yes","ENSRNOG00000065967","lncRNA","chr9:93540669-93545834:-","gi|148691168|gb|EDL23115.1|",138,1e-06,"mCG145372, partial [Mus musculus]","gi|354797743|gb|JN962244.1|",127,{"v":2e-57,"d":"2.00E-57"},"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Gpr35:tm1a(EUCOMM)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam03276","Gag_spuma","Spumavirus gag protein.",".",".",".",".","."]
["ENSRNOG00000068999",12,0.996319926,5,0.321652191,3.097507041,1.631107562,0.025479741,0.018098213,"up","yes","ENSRNOG00000068999","lncRNA","chr9:61736763-61743926:-","gi|149060708|gb|EDM11422.1|",139,3e-07,"rCG52991, isoform CRA_d [Rattus norvegicus]","gi|672065424|ref|XM_008767175.1|",2209,0,"PREDICTED: Rattus norvegicus neurobeachin-like 1 (Nbeal1), transcript variant X4, mRNA",".",".",".",".",".",".",".",".","pfam11667","DUF3267","Protein of unknown function (DUF3267). This family of proteins has no known function.",".",".",".",".","."]
["ENSRNOG00000046763",17,1.411453229,9,0.578973944,2.437852764,1.285610996,0.026072609,0.018447601,"up","yes","Adssl1","protein_coding","chr6:131679701-131701998:+","gi|109479984|ref|XP_001072867.1|",2363,0,"PREDICTED: adenylosuccinate synthetase isozyme 1 isoform X1 [Rattus norvegicus]","gi|672021207|ref|XM_001072867.5|",1786,0,"PREDICTED: Rattus norvegicus adenylosuccinate synthase like 1 (Adssl1), transcript variant X1, mRNA","P28650",913,0,"Adenylosuccinate synthetase isozyme 1","SPAC144.03",493,{"v":2e-168,"d":"2.00E-168"},"COG0104","pfam00709","Adenylsucc_synt","Adenylosuccinate synthetase.","GO:0006163|purine nucleotide metabolic process;GO:0006167|AMP biosynthetic process;GO:0006531|aspartate metabolic process;GO:0006541|glutamine metabolic process;GO:0009168|purine ribonucleoside monophosphate biosynthetic process;GO:0014850|response to muscle activity;GO:0042594|response to starvation;GO:0044208|'de novo' AMP biosynthetic process;GO:0044209|AMP salvage;GO:0046040|IMP metabolic process;GO:0071257|cellular response to electrical stimulus;GO:0071466|cellular response to xenobiotic stimulus;","GO:0005737|cytoplasm;","GO:0000287|magnesium ion binding;GO:0003924|GTPase activity;GO:0004019|adenylosuccinate synthase activity;GO:0005525|GTP binding;GO:0042802|identical protein binding;GO:0051015|actin filament binding;","K01939","purA, ADSS; adenylosuccinate synthase [EC:6.3.4.4]"]
["ENSRNOG00000062552",17,1.411453229,9,0.578973944,2.437852764,1.285610996,0.026072609,0.018447601,"up","yes","Garem1","protein_coding","chr18:12423882-12585345:-","gi|134288888|ref|NP_001028617.2|",4477,0,"GRB2-associated and regulator of MAPK protein [Mus musculus]","gi|134288887|ref|NM_001033445.2|",2711,0,"Mus musculus GRB2 associated, regulator of MAPK1 (Garem), mRNA","Q3UFT3",1731,0,"GRB2-associated and regulator of MAPK protein",".",".",".",".","pfam12736","CABIT","Cell-cycle sustaining, positive selection,. The 'CABIT' domain (for 'cysteine-containing, all- in Themis') is found in a newly identified gene family that has three mammalian homologues (Themis, Icb1 and 9130404H23Rik) that encode proteins with two CABIT domains and a highly conserved proline-rich region. In contrast, Fam59A, Fam59B and related proteins from mammals to cnidarians, including the insect Serrano proteins, have a single copy of the CABIT domain, a proline-rich region and often a C-terminal SAM (sterile-motif) domain. Multiple-sequence alignment has predicted that the CABIT domain adopts an all-strand structure with at least 12 strands, ie a dyad of six-stranded beta-barrel units. The CABIT domain contains a nearly absolutely conserved cysteine residue which is likely to be central to its function. CABIT domain proteins function downstream of tyrosine kinase signalling and interact with GRB2.",".",".",".",".","."]
["ENSRNOG00000020118",18,1.494479889,10,0.643304382,2.323130281,1.216070063,0.028376277,0.019938556,"up","yes","Nme5","protein_coding","chr18:26163555-26180794:-","gi|392334100|ref|XP_003753081.1|",1122,{"v":4e-149,"d":"4.00E-149"},"PREDICTED: nucleoside diphosphate kinase homolog 5 [Rattus norvegicus]","gi|672030575|ref|XM_003753033.3|",1177,0,"PREDICTED: Rattus norvegicus NME/NM23 family member 5 (Nme5), mRNA","Q99MH5",414,{"v":8e-142,"d":"8.00E-142"},"Nucleoside diphosphate kinase homolog 5","VC0756",103,{"v":7e-25,"d":"7.00E-25"},"COG0105","pfam00334","NDK","Nucleoside diphosphate kinase.","GO:0003351|epithelial cilium movement;GO:0006165|nucleoside diphosphate phosphorylation;GO:0006183|GTP biosynthetic process;GO:0006228|UTP biosynthetic process;GO:0006241|CTP biosynthetic process;GO:0007286|spermatid development;GO:0021591|ventricular system development;GO:0060271|cilium assembly;GO:1902176|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;","GO:0005576|extracellular region;GO:0005929|cilium;GO:0036126|sperm flagellum;","GO:0004550|nucleoside diphosphate kinase activity;","K20790","NME5; nucleoside diphosphate kinase homolog 5"]
["ENSRNOG00000032877",18,1.494479889,10,0.643304382,2.323130281,1.216070063,0.028376277,0.019938556,"up","yes","AABR07072261.1","protein_coding","chr11:80408680-80409072:+","gi|30109302|gb|AAH51205.1|",671,{"v":4e-88,"d":"4.00E-88"},"Rps15a protein, partial [Mus musculus]","gi|298901578|emb|FQ221720.1|",369,0,"Rattus norvegicus TL0ADA32YK23 mRNA sequence","P62246",261,{"v":3e-89,"d":"3.00E-89"},"40S ribosomal protein S15a","YJL190c",212,{"v":4E-70,"d":"4.00E-70"},"COG0096","pfam00410","Ribosomal_S8","Ribosomal protein S8.","GO:0006412|translation;",".",".",".","."]
["ENSRNOG00000063099",18,1.494479889,10,0.643304382,2.323130281,1.216070063,0.028376277,0.019938556,"up","yes","Gcnt7","protein_coding","chr3:161211853-161227230:-","gi|564344800|ref|XP_006235769.1|",2327,0,"PREDICTED: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7 [Rattus norvegicus]","gi|672017811|ref|XM_006224757.2|",2084,0,"PREDICTED: Rattus norvegicus beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7-like (LOC102550196), mRNA","Q3V3K7",753,0,"Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7",".",".",".",".","pfam02485","Branch","Core-2/I-Branching enzyme. This is a family of two different beta-1,6-N-acetylglucosaminyltransferase enzymes, I-branching enzyme and core-2 branching enzyme. I-branching enzyme is responsible for the production of the blood group I-antigen during embryonic development. Core-2 branching enzyme forms crucial side-chain branches in O-glycans.",".",".",".",".","."]
["ENSRNOG00000003457",9,0.747239945,3,0.192991315,3.871883802,1.953035657,0.028458622,0.019970082,"up","yes","Bicdl2","protein_coding","chr10:12691610-12700049:+","gi|157820849|ref|NP_001100452.1|",1745,0,"bicaudal D-related protein 2 [Rattus norvegicus]","gi|157820848|ref|NM_001106982.1|",1966,0,"Rattus norvegicus coiled-coil domain containing 64B (Ccdc64b), mRNA","Q8CHW5",629,0,"BICD family-like cargo adapter 2",".",".",".",".","pfam12795","MscS_porin","Mechanosensitive ion channel porin domain. The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are heptamers of three transmembrane subunits with seven converging M3 domains, and this MscS_porin is towards the N-terminal of the molecules. The high concentration of negative charges at the extracellular entrance of the pore helps select the cations for efflux.","GO:0047496|vesicle transport along microtubule;GO:0055107|Golgi to secretory granule transport;","GO:0005737|cytoplasm;","GO:0031267|small GTPase binding;","K16756","BICDL, CCDC64; BICD family-like cargo adapter"]
["ENSRNOG00000014156",9,0.747239945,3,0.192991315,3.871883802,1.953035657,0.028458622,0.019970082,"up","yes","Fut7","protein_coding","chr3:8239384-8242260:+","gi|41054896|ref|NP_955785.1|",1882,0,"alpha-(1,3)-fucosyltransferase 7 [Rattus norvegicus]","gi|41054895|ref|NM_199491.1|",2005,0,"Rattus norvegicus fucosyltransferase 7 (alpha (1,3) fucosyltransferase) (Fut7), mRNA","Q11131",661,0,"Alpha-(1,3)-fucosyltransferase 7",".",".",".",".","pfam00852","Glyco_transf_10","Glycosyltransferase family 10 (fucosyltransferase). This family of Fucosyltransferases are the enzymes transferring fucose from GDP-Fucose to GlcNAc in an alpha1,3 linkage. This family is know as glycosyltransferase family 10.","GO:0001807|regulation of type IV hypersensitivity;GO:0002361|CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0002522|leukocyte migration involved in immune response;GO:0002523|leukocyte migration involved in inflammatory response;GO:0006486|protein glycosylation;GO:0006672|ceramide metabolic process;GO:0006954|inflammatory response;GO:0007566|embryo implantation;GO:0022407|regulation of cell-cell adhesion;GO:0022409|positive regulation of cell-cell adhesion;GO:0036065|fucosylation;GO:0045785|positive regulation of cell adhesion;GO:0046626|regulation of insulin receptor signaling pathway;GO:0060353|regulation of cell adhesion molecule production;GO:0097021|lymphocyte migration into lymphoid organs;GO:1903037|regulation of leukocyte cell-cell adhesion;GO:1903236|regulation of leukocyte tethering or rolling;GO:1903238|positive regulation of leukocyte tethering or rolling;GO:1904994|regulation of leukocyte adhesion to vascular endothelial cell;GO:1904996|positive regulation of leukocyte adhesion to vascular endothelial cell;GO:2000389|regulation of neutrophil extravasation;","GO:0005794|Golgi apparatus;GO:0005802|trans-Golgi network;GO:0016021|integral component of membrane;GO:0032580|Golgi cisterna membrane;","GO:0008417|fucosyltransferase activity;GO:0017083|4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity;GO:0046920|alpha-(1->3)-fucosyltransferase activity;","K07635","FUT7; galactoside alpha-1,3-fucosyltransferase 7 [EC:2.4.1.-]"]
["ENSRNOG00000019857",9,0.747239945,3,0.192991315,3.871883802,1.953035657,0.028458622,0.019970082,"up","yes","ENSRNOG00000019857","lncRNA","chr7:8697521-8761240:+","gi|149034469|gb|EDL89206.1|",594,{"v":1e-67,"d":"1.00E-67"},"guanine nucleotide binding protein, gamma 7, isoform CRA_a [Rattus norvegicus]","gi|298891051|emb|FQ211653.1|",2997,0,"Rattus norvegicus TL0AAA84YH22 mRNA sequence","P43425",139,{"v":8e-37,"d":"8.00E-37"},"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7",".",".",".",".","pfam00631","G-gamma","GGL domain. G-protein gamma like domains (GGL) are found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling (RGS) proteins. It is also found fused to an inactive Galpha in the Dictyostelium protein gbqA. G-gamma likely shares a common origin with the helical N-terminal unit of G-beta. All organisms that posses a G-beta possess a G-gamma.","GO:0001662|behavioral fear response;GO:0007168|receptor guanylyl cyclase signaling pathway;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007626|locomotory behavior;GO:0008150|biological_process;GO:0045761|regulation of adenylate cyclase activity;","GO:0005834|heterotrimeric G-protein complex;","GO:0003674|molecular_function;GO:0031681|G-protein beta-subunit binding;","K04543","GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7"]
["ENSRNOG00000026503",9,0.747239945,3,0.192991315,3.871883802,1.953035657,0.028458622,0.019970082,"up","yes","Xrra1","protein_coding","chr1:154183377-154247895:+","gi|392337832|ref|XP_003753370.1|",4111,0,"PREDICTED: X-ray radiation resistance-associated protein 1 isoform X1 [Rattus norvegicus]","gi|672014077|ref|XM_003753322.3|",2757,0,"PREDICTED: Rattus norvegicus X-ray radiation resistance associated 1 (Xrra1), transcript variant X1, mRNA","Q3U3V8",1497,0,"X-ray radiation resistance-associated protein 1",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.","GO:0010165|response to X-ray;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0016604|nuclear body;",".",".","."]
["ENSRNOG00000056001",9,0.747239945,3,0.192991315,3.871883802,1.953035657,0.028458622,0.019970082,"up","yes","Sftpd","protein_coding","chr16:17046483-17059927:-","gi|643358557|gb|AIA98493.1|",872,{"v":2e-110,"d":"2.00E-110"},"pulmonary surfactant protein D [Sigmodon hispidus]","gi|672079518|ref|XM_008771065.1|",1244,0,"PREDICTED: Rattus norvegicus surfactant protein D (Sftpd), transcript variant X1, mRNA","P35248",330,{"v":1E-107,"d":"1.00E-107"},"Pulmonary surfactant-associated protein D",".",".",".",".","pfam09006","Surfac_D-trimer","Lung surfactant protein D coiled-coil trimerization. This domain, predominantly found in lung surfactant protein D, forms a triple-helical parallel coiled coil, and mediates trimerization of the protein.","GO:0007585|respiratory gaseous exchange;GO:0008228|opsonization;GO:0031960|response to corticosteroid;GO:0032703|negative regulation of interleukin-2 production;GO:0042130|negative regulation of T cell proliferation;GO:0043129|surfactant homeostasis;GO:0043152|induction of bacterial agglutination;GO:0045087|innate immune response;GO:0048286|lung alveolus development;GO:0050765|negative regulation of phagocytosis;GO:0050766|positive regulation of phagocytosis;GO:0050828|regulation of liquid surface tension;GO:0051384|response to glucocorticoid;GO:0052403|negative regulation by host of symbiont catalytic activity;GO:0055093|response to hyperoxia;GO:0070848|response to growth factor;GO:1905226|regulation of adhesion of symbiont to host epithelial cell;","GO:0005581|collagen trimer;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005771|multivesicular body;GO:0005791|rough endoplasmic reticulum;GO:0031410|cytoplasmic vesicle;","GO:0001530|lipopolysaccharide binding;GO:0030246|carbohydrate binding;GO:0042802|identical protein binding;GO:0048029|monosaccharide binding;","K10068","SFTPD, SFTP4; pulmonary surfactant-associated protein D"]
["ENSRNOG00000056781",9,0.747239945,3,0.192991315,3.871883802,1.953035657,0.028458622,0.019970082,"up","yes","Cfap221","protein_coding","chr13:31046535-31116899:-","gi|672073896|ref|XP_008767728.1|",4189,0,"PREDICTED: primary ciliary dyskinesia protein 1 isoform X2 [Rattus norvegicus]","gi|672073895|ref|XM_008769506.1|",2915,0,"PREDICTED: Rattus norvegicus cilia and flagella associated protein 221 (Cfap221), transcript variant X2, mRNA","A9Q751",1447,0,"Cilia- and flagella-associated protein 221",".",".",".",".","pfam03999","MAP65_ASE1","Microtubule associated protein (MAP65/ASE1 family).","GO:0044458|motile cilium assembly;GO:0090660|cerebrospinal fluid circulation;","GO:0005576|extracellular region;GO:0036126|sperm flagellum;GO:0097729|9+2 motile cilium;","GO:0005516|calmodulin binding;","K25610","CFAP221, PCDP1; cilia- and flagella-associated protein 221"]
["ENSRNOG00000060087",9,0.747239945,3,0.192991315,3.871883802,1.953035657,0.028458622,0.019970082,"up","yes","Adra1b","protein_coding","chr10:28255025-28312919:-","gi|543734|sp|P15823.2|ADA1B_RAT",2601,0,"RecName: Full=Alpha-1B adrenergic receptor; AltName: Full=Alpha-1B adrenoreceptor; Short=Alpha-1B adrenoceptor","gi|47575852|ref|NM_016991.2|",2484,0,"Rattus norvegicus adrenoceptor alpha 1B (Adra1b), mRNA","P15823",1006,0,"Alpha-1B adrenergic receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001974|blood vessel remodeling;GO:0001975|response to amphetamine;GO:0001987|vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure;GO:0001996|positive regulation of heart rate by epinephrine-norepinephrine;GO:0001997|positive regulation of the force of heart contraction by epinephrine-norepinephrine;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007267|cell-cell signaling;GO:0007512|adult heart development;GO:0007626|locomotory behavior;GO:0008217|regulation of blood pressure;GO:0008542|visual learning;GO:0009410|response to xenobiotic stimulus;GO:0009725|response to hormone;GO:0010259|multicellular organism aging;GO:0019229|regulation of vasoconstriction;GO:0035024|negative regulation of Rho protein signal transduction;GO:0035265|organ growth;GO:0042593|glucose homeostasis;GO:0043278|response to morphine;GO:0043410|positive regulation of MAPK cascade;GO:0043627|response to estrogen;GO:0045818|negative regulation of glycogen catabolic process;GO:0045819|positive regulation of glycogen catabolic process;GO:0045907|positive regulation of vasoconstriction;GO:0048148|behavioral response to cocaine;GO:0048545|response to steroid hormone;GO:0055117|regulation of cardiac muscle contraction;GO:0061049|cell growth involved in cardiac muscle cell development;GO:0071875|adrenergic receptor signaling pathway;GO:0071880|adenylate cyclase-activating adrenergic receptor signaling pathway;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005901|caveola;GO:0014704|intercalated disc;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030315|T-tubule;GO:0031965|nuclear membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004937|alpha1-adrenergic receptor activity;GO:0046982|protein heterodimerization activity;","K04136","ADRA1B; adrenergic receptor alpha-1B"]
["ENSRNOG00000061883",9,0.747239945,3,0.192991315,3.871883802,1.953035657,0.028458622,0.019970082,"up","yes","Aqp9","protein_coding","chr8:71797234-71837395:-","gi|12621144|ref|NP_075249.1|",1532,0,"aquaporin-9 [Rattus norvegicus]","gi|55742829|ref|NM_022960.2|",1715,0,"Rattus norvegicus aquaporin 9 (Aqp9), mRNA","P56627",594,0,"Aquaporin-9","PA3581",163,{"v":9e-45,"d":"9.00E-45"},"COG0580","pfam00230","MIP","Major intrinsic protein. MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.","GO:0006833|water transport;GO:0006863|purine nucleobase transport;GO:0010033|response to organic substance;GO:0015722|canalicular bile acid transport;GO:0015791|polyol transport;GO:0015793|glycerol transport;GO:0015837|amine transport;GO:0015855|pyrimidine nucleobase transport;GO:0046689|response to mercury ion;GO:0071320|cellular response to cAMP;GO:0071918|urea transmembrane transport;GO:0072531|pyrimidine-containing compound transmembrane transport;GO:1904823|purine nucleobase transmembrane transport;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016323|basolateral plasma membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0005345|purine nucleobase transmembrane transporter activity;GO:0005350|pyrimidine nucleobase transmembrane transporter activity;GO:0005515|protein binding;GO:0015204|urea transmembrane transporter activity;GO:0015250|water channel activity;GO:0015254|glycerol channel activity;GO:0015265|urea channel activity;","K09877","AQP9; aquaporin-9"]
["ENSRNOG00000067465",9,0.747239945,3,0.192991315,3.871883802,1.953035657,0.028458622,0.019970082,"up","yes","ENSRNOG00000067465","lncRNA","chr3:115420794-115422432:-","gi|149023241|gb|EDL80135.1|",310,{"v":4e-33,"d":"4.00E-33"},"rCG26742 [Rattus norvegicus]","gi|672017319|ref|XR_345178.2|",694,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102555660 (LOC102555660), transcript variant X2, ncRNA",".",".",".",".",".",".",".",".","pfam08491","SE","Squalene epoxidase. This domain is found in squalene epoxidase (SE) and related proteins which are found in taxonomically diverse groups of eukaryotes and also in bacteria.  SE was first cloned from Saccharomyces cerevisiae where it was named ERG1. It contains a putative FAD binding site and is a key enzyme in the sterol biosynthetic pathway. Putative transmembrane regions are found to the protein's C-terminus.",".",".",".",".","."]
["ENSRNOG00000067737",9,0.747239945,3,0.192991315,3.871883802,1.953035657,0.028458622,0.019970082,"up","yes","ENSRNOG00000067737","protein_coding","chr1:1232112-1232723:+","gi|149020012|gb|EDL78160.1|",825,{"v":5E-108,"d":"5.00E-108"},"rCG36659, isoform CRA_d [Rattus norvegicus]","gi|755553470|ref|XM_011245879.1|",401,0,"PREDICTED: Mus musculus ATPase type 13A3 (Atp13a3), transcript variant X1, mRNA","Q5XF89",301,{"v":1e-93,"d":"1.00E-93"},"Probable cation-transporting ATPase 13A3",".",".",".",".","pfam12409","P5-ATPase","P5-type ATPase cation transporter. This domain family is found in eukaryotes, and is typically between 110 and 126 amino acids in length. The family is found in association with pfam00122, pfam00702. P-type ATPases comprise a large superfamily of proteins, present in both prokaryotes and eukaryotes, that transport inorganic cations and other substrates across cell membranes.",".",".",".",".","."]
["ENSRNOG00000003234",13,1.079346587,6,0.385982629,2.796360524,1.483550374,0.030030006,0.020900727,"up","yes","Mgrn1","protein_coding","chr10:10638880-10688315:-","gi|672066545|ref|XP_008765707.1|",2693,0,"PREDICTED: E3 ubiquitin-protein ligase MGRN1 isoform X6 [Rattus norvegicus]","gi|672066544|ref|XM_008767485.1|",3248,0,"PREDICTED: Rattus norvegicus mahogunin ring finger 1, E3 ubiquitin protein ligase (Mgrn1), transcript variant X6, mRNA","Q5XIQ4",980,0,"E3 ubiquitin-protein ligase MGRN1",".",".",".",".","pfam13920","zf-C3HC4_3","Zinc finger, C3HC4 type (RING finger).","GO:0000209|protein polyubiquitination;GO:0006513|protein monoubiquitination;GO:0008150|biological_process;GO:0008333|endosome to lysosome transport;GO:0016567|protein ubiquitination;GO:0043951|negative regulation of cAMP-mediated signaling;GO:0045744|negative regulation of G protein-coupled receptor signaling pathway;GO:0045879|negative regulation of smoothened signaling pathway;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005769|early endosome;GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0003674|molecular_function;GO:0004842|ubiquitin-protein transferase activity;GO:0005515|protein binding;GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;","K10604","MGRN1; E3 ubiquitin-protein ligase MGRN1 [EC:2.3.2.27]"]
["ENSRNOG00000005920",13,1.079346587,6,0.385982629,2.796360524,1.483550374,0.030030006,0.020900727,"up","yes","AABR07054266.1","protein_coding","chr3:138600187-138600965:-","gi|157819033|ref|NP_001099680.1|",1035,{"v":2E-140,"d":"2.00E-140"},"ribonuclease T2 precursor [Rattus norvegicus]","gi|197246456|gb|BC168957.1|",507,0,"Rattus norvegicus ribonuclease T2, mRNA (cDNA clone MGC:189268 IMAGE:9098746), complete cds","C0HKG6",387,{"v":1E-135,"d":"1.00E-135"},"Ribonuclease T2-B",".",".",".",".","pfam00445","Ribonuclease_T2","Ribonuclease T2 family.",".",".",".",".","."]
["ENSRNOG00000068322",13,1.079346587,6,0.385982629,2.796360524,1.483550374,0.030030006,0.020900727,"up","yes","ENSRNOG00000068322","lncRNA","chrX:14254684-14266298:+",".",".",".",".","gi|672032061|ref|XM_006227284.2|",203,{"v":2E-100,"d":"2.00E-100"},"PREDICTED: Rattus norvegicus FtsJ RNA methyltransferase homolog 1 (E. coli) (Ftsj1), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam09234","DUF1963","Domain of unknown function (DUF1963). This domain is found in a set of hypothetical bacterial proteins. Its exact function has not, as yet, been described.",".",".",".",".","."]
["ENSRNOG00000000199",19,1.57750655,11,0.70763482,2.229266431,1.156569051,0.03045533,0.021169099,"up","yes","Dppa5","protein_coding","chr8:79215362-79216570:-","gi|27718517|ref|XP_235194.1|",609,{"v":4e-77,"d":"4.00E-77"},"PREDICTED: developmental pluripotency-associated protein 5A-like [Rattus norvegicus]","gi|672023098|ref|XM_001059859.3|",710,0,"PREDICTED: Rattus norvegicus developmental pluripotency associated 5 (Dppa5), mRNA","Q9CQS7",195,{"v":2e-61,"d":"2.00E-61"},"Developmental pluripotency-associated protein 5A",".",".",".",".","pfam12128","DUF3584","Protein of unknown function (DUF3584). This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.","GO:0010468|regulation of gene expression;","GO:0005737|cytoplasm;","GO:0003729|mRNA binding;",".","."]
["ENSRNOG00000002834",19,1.57750655,11,0.70763482,2.229266431,1.156569051,0.03045533,0.021169099,"up","yes","Klb","protein_coding","chr14:42899510-42950799:-","gi|13626032|ref|NP_112457.1|",5233,0,"beta-klotho [Mus musculus]","gi|118130737|ref|NM_031180.2|",2671,0,"Mus musculus klotho beta (Klb), mRNA","Q99N32",2020,0,"Beta-klotho","BH1923",232,{"v":4e-65,"d":"4.00E-65"},"COG2723","pfam00232","Glyco_hydro_1","Glycosyl hydrolase family 1.",".",".",".",".","."]
["ENSRNOG00000019789",19,1.57750655,11,0.70763482,2.229266431,1.156569051,0.03045533,0.021169099,"up","yes","Tssk4","protein_coding","chr15:29141792-29144128:+","gi|404441531|ref|NP_001258254.1|",1471,0,"testis-specific serine/threonine-protein kinase 4 [Rattus norvegicus]","gi|404441530|ref|NM_001271325.1|",1376,0,"Rattus norvegicus testis-specific serine kinase 4 (Tssk4), transcript variant 1, mRNA","Q9D411",513,{"v":1E-179,"d":"1.00E-179"},"Testis-specific serine/threonine-protein kinase 4",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006468|protein phosphorylation;GO:0007286|spermatid development;GO:0009566|fertilization;GO:0018105|peptidyl-serine phosphorylation;GO:0030317|flagellated sperm motility;GO:0032793|positive regulation of CREB transcription factor activity;GO:0035556|intracellular signal transduction;GO:1990443|peptidyl-threonine autophosphorylation;","GO:0031514|motile cilium;GO:0036126|sperm flagellum;","GO:0000287|magnesium ion binding;GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0044877|protein-containing complex binding;","K08811","TSSK, STK22; testis-specific serine kinase [EC:2.7.11.1]"]
["ENSRNOG00000020148",21,1.743559871,13,0.836295696,2.084860509,1.059950861,0.033980005,0.023362666,"up","yes","Il4i1","protein_coding","chr1:95295601-95324562:+","gi|293355926|ref|XP_002728790.1|",3208,0,"PREDICTED: L-amino-acid oxidase isoform X2 [Rattus norvegicus]","gi|672036732|ref|XM_006229191.2|",2234,0,"PREDICTED: Rattus norvegicus rCG53598-like (LOC100360621), transcript variant X6, mRNA","O09046",988,0,"L-amino-acid oxidase","BS_yobN",207,{"v":4e-56,"d":"4.00E-56"},"COG1231","pfam01593","Amino_oxidase","Flavin containing amine oxidoreductase. This family consists of various amine oxidases, including maze polyamine oxidase (PAO) and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.","GO:0002819|regulation of adaptive immune response;GO:0002841|negative regulation of T cell mediated immune response to tumor cell;GO:0006559|L-phenylalanine catabolic process;GO:0006569|tryptophan catabolic process;GO:0006572|tyrosine catabolic process;GO:0009063|cellular amino acid catabolic process;GO:0019440|tryptophan catabolic process to indole-3-acetate;GO:0042130|negative regulation of T cell proliferation;GO:0045591|positive regulation of regulatory T cell differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050868|negative regulation of T cell activation;","GO:0001669|acrosomal vesicle;GO:0001772|immunological synapse;GO:0005576|extracellular region;GO:0097225|sperm midpiece;","GO:0001716|L-amino-acid oxidase activity;GO:0016491|oxidoreductase activity;GO:0046592|polyamine oxidase activity;","K03334","IL4I1; L-amino-acid oxidase [EC:1.4.3.2]"]
["ENSRNOG00000032085",21,1.743559871,13,0.836295696,2.084860509,1.059950861,0.033980005,0.023362666,"up","yes","Dlec1","protein_coding","chr8:118826466-118873655:+","gi|564310825|ref|XP_006226675.1|",8962,0,"PREDICTED: deleted in lung and esophageal cancer protein 1 homolog isoform X3 [Rattus norvegicus]","gi|672023440|ref|XM_006226613.2|",5504,0,"PREDICTED: Rattus norvegicus deleted in lung and esophageal cancer 1 (Dlec1), transcript variant X3, mRNA","Q9Y238",2361,0,"Deleted in lung and esophageal cancer protein 1",".",".",".",".","pfam02803","Thiolase_C","Thiolase, C-terminal domain. Thiolase is reported to be structurally related to beta-ketoacyl synthase (pfam00109), and also chalcone synthase.","GO:0002357|defense response to tumor cell;GO:0007283|spermatogenesis;GO:0008150|biological_process;GO:0008285|negative regulation of cell proliferation;GO:0030154|cell differentiation;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0003674|molecular_function;GO:0043014|alpha-tubulin binding;GO:0048487|beta-tubulin binding;","K25548","DLEC1; deleted in lung and esophageal cancer protein 1"]
["ENSRNOG00000012337",14,1.162373247,7,0.450313067,2.581255868,1.368073156,0.034149253,0.023458731,"up","yes","Pde1c","protein_coding","chr4:85300858-85863219:-","gi|568941055|ref|XP_006505793.1|",3948,0,"PREDICTED: calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X2 [Mus musculus]","gi|451958122|ref|NM_031078.2|",2755,0,"Rattus norvegicus phosphodiesterase 1C (Pde1c), mRNA","Q63421",1377,0,"Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C",".",".",".",".","pfam00233","PDEase_I","3'5'-cyclic nucleotide phosphodiesterase.","GO:0007165|signal transduction;GO:0007608|sensory perception of smell;GO:0051592|response to calcium ion;GO:0061179|negative regulation of insulin secretion involved in cellular response to glucose stimulus;","GO:0005929|cilium;GO:0043025|neuronal cell body;","GO:0004114|3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0004115|3',5'-cyclic-AMP phosphodiesterase activity;GO:0004117|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity;GO:0005516|calmodulin binding;GO:0030552|cAMP binding;GO:0046872|metal ion binding;GO:0048101|calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity;","K13755","PDE1; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17]"]
["ENSRNOG00000033855",14,1.162373247,7,0.450313067,2.581255868,1.368073156,0.034149253,0.023458731,"up","yes","AABR07062466.1","protein_coding","chr4:177336069-177336633:+","gi|31560385|ref|NP_062621.2|",835,{"v":1e-111,"d":"1.00E-111"},"60S ribosomal protein L21 [Mus musculus]","gi|37231654|gb|BC058459.1|",550,0,"Rattus norvegicus ribosomal protein L21, mRNA (cDNA clone MGC:72750 IMAGE:6918772), complete cds","P49666",325,{"v":8e-113,"d":"8.00E-113"},"60S ribosomal protein L21","YBR191w",196,{"v":1E-62,"d":"1.00E-62"},"COG2139","pfam01157","Ribosomal_L21e","Ribosomal protein L21e.",".",".",".",".","."]
["ENSRNOG00000037718",14,1.162373247,7,0.450313067,2.581255868,1.368073156,0.034149253,0.023458731,"up","yes","Cfap52","protein_coding","chr10:52613762-52654934:-","gi|187281569|ref|NP_001094438.2|",3255,0,"WD repeat-containing protein 16 [Rattus norvegicus]","gi|187281568|ref|NM_001100968.2|",2225,0,"Rattus norvegicus cilia and flagella associated protein 52 (Cfap52), mRNA","Q5F201",1241,0,"Cilia- and flagella-associated protein 52","all0283_3",113,{"v":3e-25,"d":"3.00E-25"},"COG2319","pfam00400","WD40","WD domain, G-beta repeat.","GO:0030317|flagellated sperm motility;GO:0060271|cilium assembly;GO:0061966|establishment of left/right asymmetry;","GO:0005930|axoneme;GO:0097729|9+2 motile cilium;",".","K24728","CFAP52, WDR16; cilia- and flagella-associated protein 52"]
["ENSRNOG00000062948",14,1.162373247,7,0.450313067,2.581255868,1.368073156,0.034149253,0.023458731,"up","yes","Olr1461","protein_coding","chr10:43594499-43599111:+","gi|47575905|ref|NP_001000022.1|",1615,0,"olfactory receptor Olr1461 [Rattus norvegicus]","gi|354798479|gb|JN962980.1|",1335,0,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Gm12258:tm1e(EUCOMM)Wtsi tm1e(EUCOMM)Hmgu; transgenic","Q8VGS3",280,{"v":2e-83,"d":"2.00E-83"},"Olfactory receptor 1019",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.",".",".",".",".","."]
["ENSRNOG00000063741",14,1.162373247,7,0.450313067,2.581255868,1.368073156,0.034149253,0.023458731,"up","yes","ENSRNOG00000063741","protein_coding","chr5:57703909-57723062:+","gi|672019262|ref|XP_008774163.1|",185,{"v":1e-12,"d":"1.00E-12"},"PREDICTED: prothymosin alpha-like [Rattus norvegicus]","gi|672019261|ref|XM_008775941.1|",2635,0,"PREDICTED: Rattus norvegicus RGD1560723 (RGD1560723), mRNA",".",".",".",".",".",".",".",".","pfam00607","Gag_p24","gag gene protein p24 (core nucleocapsid protein). p24 forms inner protein layer of the nucleocapsid. ELISA tests for p24 is the most commonly used method to demonstrate virus replication both in vivo and in vitro.",".",".",".",".","."]
["ENSRNOG00000068035",14,1.162373247,7,0.450313067,2.581255868,1.368073156,0.034149253,0.023458731,"up","yes","ENSRNOG00000068035","lncRNA","chr9:91989910-91996480:-","gi|149037585|gb|EDL92016.1|",472,{"v":6E-51,"d":"6.00E-51"},"rCG55683, partial [Rattus norvegicus]","gi|354796880|gb|JN961381.1|",1414,0,"Mus musculus targeted deletion, lacZ-tagged mutant allele Hes6:tm1(KOMP)Wtsi; transgenic",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["ENSRNOG00000000454",22,1.826586532,14,0.900626135,2.028129611,1.020149853,0.0354509,0.024257167,"up","yes","RT1-DOb","protein_coding","chr20:4619816-4625667:-","gi|57012350|ref|NP_001008846.1|",807,{"v":5e-97,"d":"5.00E-97"},"RT1 class II, DO beta [Rattus norvegicus]","gi|89214481|gb|AC120734.5|",2190,0,"Rattus norvegicus BAC CH230-220D1 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P13765",229,{"v":1e-66,"d":"1.00E-66"},"HLA class II histocompatibility antigen, DO beta chain",".",".",".",".","pfam00969","MHC_II_beta","Class II histocompatibility antigen, beta domain.","GO:0002250|adaptive immune response;GO:0002381|immunoglobulin production involved in immunoglobulin mediated immune response;GO:0002503|peptide antigen assembly with MHC class II protein complex;GO:0002587|negative regulation of antigen processing and presentation of peptide antigen via MHC class II;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0050870|positive regulation of T cell activation;","GO:0005764|lysosome;GO:0016021|integral component of membrane;GO:0042613|MHC class II protein complex;","GO:0023026|MHC class II protein complex binding;","K06752","MHC2; MHC class II antigen"]
["ENSRNOG00000049642",22,1.826586532,14,0.900626135,2.028129611,1.020149853,0.0354509,0.024257167,"up","yes","Smim5","protein_coding","chr10:101134033-101139813:+","gi|817278049|ref|XP_012309130.1|",218,{"v":1e-18,"d":"1.00E-18"},"PREDICTED: small integral membrane protein 5 isoform X1 [Aotus nancymaae]","gi|478246974|ref|NM_001277479.1|",1049,0,"Rattus norvegicus small integral membrane protein 5 (Smim5), transcript variant 1, mRNA","Q71RC9",85.1,{"v":3e-19,"d":"3.00E-19"},"Small integral membrane protein 5",".",".",".",".","pfam04770","ZF-HD_dimer","ZF-HD protein dimerization region. This family of proteins has are plant transcription factors, and have been named ZF-HD for zinc finger homeodomain proteins, on the basis of similarity to proteins of known structure. This region is thought to be involved in the formation of homo and heterodimers, and may form a zinc finger.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000000487",10,0.830266605,4,0.257321753,3.226569835,1.690001251,0.036476051,0.024864782,"up","yes","Grm4","protein_coding","chr20:5481124-5572821:-","gi|400255|sp|P31423.1|GRM4_RAT",4592,0,"RecName: Full=Metabotropic glutamate receptor 4; Short=mGluR4; Flags: Precursor","gi|12083594|ref|NM_022666.1|",4282,0,"Rattus norvegicus glutamate receptor, metabotropic 4 (Grm4), mRNA","P31423",1773,0,"Metabotropic glutamate receptor 4",".",".",".",".","pfam00003","7tm_3","7 transmembrane sweet-taste receptor of 3 GCPR. This is a domain of seven transmembrane regions that forms the C-terminus of some subclass 3 G-coupled-protein receptors. It is often associated with a downstream cysteine-rich linker domain, NCD3G pfam07562, which is the human sweet-taste receptor, and the N-terminal domain, ANF_receptor pfam01094. The seven TM regions assemble in such a way as to produce a docking pocket into which such molecules as cyclamate and lactisole have been found to bind and consequently confer the taste of sweetness.","GO:0007196|adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway;GO:0007216|G protein-coupled glutamate receptor signaling pathway;GO:0007268|chemical synaptic transmission;GO:0007612|learning;GO:0008285|negative regulation of cell proliferation;GO:0014051|gamma-aminobutyric acid secretion;GO:0031175|neuron projection development;GO:0035249|synaptic transmission, glutamatergic;GO:0043066|negative regulation of apoptotic process;GO:0043410|positive regulation of MAPK cascade;GO:0043523|regulation of neuron apoptotic process;GO:0050805|negative regulation of synaptic transmission;GO:0051932|synaptic transmission, GABAergic;GO:0051966|regulation of synaptic transmission, glutamatergic;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0005887|integral component of plasma membrane;GO:0031410|cytoplasmic vesicle;GO:0043005|neuron projection;GO:0043195|terminal bouton;GO:0043198|dendritic shaft;GO:0048787|presynaptic active zone membrane;GO:0098688|parallel fiber to Purkinje cell synapse;GO:0098978|glutamatergic synapse;GO:0099059|integral component of presynaptic active zone membrane;","GO:0001640|adenylate cyclase inhibiting G protein-coupled glutamate receptor activity;GO:0004930|G protein-coupled receptor activity;GO:0005515|protein binding;GO:0005516|calmodulin binding;GO:0008066|glutamate receptor activity;GO:0048306|calcium-dependent protein binding;","K04607","GRM4; metabotropic glutamate receptor 4"]
["ENSRNOG00000037217",10,0.830266605,4,0.257321753,3.226569835,1.690001251,0.036476051,0.024864782,"up","yes","Nudt17","protein_coding","chr2:184241468-184243960:-","gi|157819083|ref|NP_001102810.1|",1455,0,"nucleoside diphosphate-linked moiety X motif 17 [Rattus norvegicus]","gi|157819082|ref|NM_001109340.1|",1118,0,"Rattus norvegicus nudix hydrolase 17 (Nudt17), mRNA","Q9CWD3",505,{"v":2e-178,"d":"2.00E-178"},"Nucleoside diphosphate-linked moiety X motif 17",".",".",".",".","pfam00293","NUDIX","NUDIX domain.","GO:0006734|NADH metabolic process;GO:0006742|NADP catabolic process;GO:0019677|NAD catabolic process;","GO:0005777|peroxisome;GO:0005829|cytosol;","GO:0035529|NADH pyrophosphatase activity;",".","."]
["ENSRNOG00000068755",10,0.830266605,4,0.257321753,3.226569835,1.690001251,0.036476051,0.024864782,"up","yes","ENSRNOG00000068755","lncRNA","chr8:58049228-58051547:+","gi|149033621|gb|EDL88419.1|",132,6e-07,"rCG61286, isoform CRA_a [Rattus norvegicus]","gi|47777566|gb|AC122528.3|",297,{"v":3E-152,"d":"3.00E-152"},"Mus musculus BAC clone RP24-506F15 from chromosome 9, complete sequence",".",".",".",".",".",".",".",".","pfam09508","Lact_bio_phlase","Lacto-N-biose phosphorylase. The gene which codes for this protein in gut-bacteria is located in a novel putative operon for galactose metabolizm. The protein appears to be a carbohydrate-processing phosphorolytic enzyme (EC:2.4.1.211), unlike either glycoside hydrolases or glycoside lyase. Intestinal colonisation by bifidobacteria is important for human health, especially in pediatrics, because colonisation seems to prevent infection by some pathogenic bacteria that cause diarrhoea or other illnesses. The operon seems to be involved in intestinal colonisation by bifidobacteria mediated by metabolizm of mucin sugars. In addition, it may also resolve the question of the nature of the bifidus factor in human milk as the lacto-N-biose structure found in milk oligosaccharides.",".",".",".",".","."]
["ENSRNOG00000069978",10,0.830266605,4,0.257321753,3.226569835,1.690001251,0.036476051,0.024864782,"up","yes","ENSRNOG00000069978","lncRNA","chr10:44167681-44185997:+",".",".",".",".","gi|672024823|ref|XR_338639.2|",785,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102546363 (LOC102546363), transcript variant X3, ncRNA",".",".",".",".",".",".",".",".","pfam03040","CemA","CemA family. Members of this family are probable integral membrane proteins. Their molecular function is unknown. CemA proteins are found in the inner envelope membrane of chloroplasts but not in the thylakoid membrane. A cyanobacterial member of this family has been implicated in CO2 transport, but is probably not a CO2 transporter itself. They are predicted to be haem-binding however this has not been proven experimentally.",".",".",".",".","."]
["ENSRNOG00000007484",15,1.245399908,8,0.514643505,2.419927376,1.274963752,0.037832773,0.025539135,"up","yes","Ehf","protein_coding","chr3:89641833-89679997:-","gi|157817348|ref|NP_001099963.1|",1631,0,"ETS homologous factor [Rattus norvegicus]","gi|187937127|ref|NM_001106493.2|",2337,0,"Rattus norvegicus ets homologous factor (Ehf), mRNA","O70273",624,0,"ETS homologous factor",".",".",".",".","pfam00178","Ets","Ets-domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0006366|transcription by RNA polymerase II;GO:0030154|cell differentiation;GO:0030855|epithelial cell differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050673|epithelial cell proliferation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005794|Golgi apparatus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;","K17102","EHF; ETS homologous factor"]
["ENSRNOG00000008010",15,1.245399908,8,0.514643505,2.419927376,1.274963752,0.037832773,0.025539135,"up","yes","Hoxb5","protein_coding","chr10:81269372-81271580:+","gi|556738352|ref|XP_005964751.1|",1075,{"v":3e-141,"d":"3.00E-141"},"PREDICTED: homeobox protein Hox-B5 [Pantholops hodgsonii]","gi|672068879|ref|XM_008768104.1|",1534,0,"PREDICTED: Rattus norvegicus homeo box B5 (Hoxb5), transcript variant X1, mRNA","P09079",414,{"v":7e-141,"d":"7.00E-141"},"Homeobox protein Hox-B5",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0009952|anterior/posterior pattern specification;GO:0045446|endothelial cell differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048704|embryonic skeletal system morphogenesis;GO:0048706|embryonic skeletal system development;","GO:0001650|fibrillar center;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:1990837|sequence-specific double-stranded DNA binding;","K09305","HOX_5; homeobox protein HoxA/B/C5"]
["ENSRNOG00000026918",15,1.245399908,8,0.514643505,2.419927376,1.274963752,0.037832773,0.025539135,"up","yes","RGD1308065","protein_coding","chr11:83882350-83895873:+","gi|149019727|gb|EDL77875.1|",1386,0,"hypothetical LOC287935 (predicted), isoform CRA_a [Rattus norvegicus]","gi|117940026|ref|NM_001077666.1|",1578,0,"Rattus norvegicus hypothetical LOC287935 (RGD1308065), mRNA",".",".",".",".",".",".",".",".","pfam11573","Med23","Mediator complex subunit 23. Med23 is one of the subunits of the Tail portion of the Mediator complex that regulates RNA polymerase II activity. Med23 is required for heat-shock-specific gene expression, and has been shown to mediate transcriptional activation of E1A in mice.",".",".",".",".","."]
["ENSRNOG00000003654",7,0.581186624,2,0.128660876,4.517197769,2.175428078,0.038372534,0.025824436,"up","yes","Cldn6","protein_coding","chr10:12709960-12715973:+","gi|156231010|ref|NP_001095834.1|",875,{"v":2e-104,"d":"2.00E-104"},"claudin-6 precursor [Rattus norvegicus]","gi|354794369|gb|JN958870.1|",1634,0,"Mus musculus targeted deletion, lacZ-tagged mutant allele Hcfc1r1:tm1(KOMP)Wtsi; transgenic","Q9Z262",327,{"v":1E-100,"d":"1.00E-100"},"Claudin-6",".",".",".",".","pfam00822","PMP22_Claudin","PMP-22/EMP/MP20/Claudin family.","GO:0007155|cell adhesion;GO:0045216|cell-cell junction organization;GO:0046718|viral entry into host cell;GO:0070830|bicellular tight junction assembly;GO:0120193|tight junction organization;","GO:0005886|plasma membrane;GO:0005923|bicellular tight junction;GO:0016021|integral component of membrane;GO:0030054|cell junction;GO:0043231|intracellular membrane-bounded organelle;","GO:0001618|virus receptor activity;GO:0005198|structural molecule activity;","K06087","CLDN; claudin"]
["ENSRNOG00000011320",7,0.581186624,2,0.128660876,4.517197769,2.175428078,0.038372534,0.025824436,"up","yes","Igfbpl1","protein_coding","chr5:60076429-60091833:-","gi|157822835|ref|NP_001102442.1|",936,{"v":3e-121,"d":"3.00E-121"},"insulin-like growth factor-binding protein-like 1 precursor [Rattus norvegicus]","gi|166157818|ref|NM_001108972.2|",1328,0,"Rattus norvegicus insulin-like growth factor binding protein-like 1 (Igfbpl1), mRNA","Q80W15",358,{"v":4e-120,"d":"4.00E-120"},"Insulin-like growth factor-binding protein-like 1",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0001558|regulation of cell growth;GO:0009966|regulation of signal transduction;GO:0071228|cellular response to tumor cell;","GO:0005615|extracellular space;","GO:0005520|insulin-like growth factor binding;","K24197","IGFBPL1; insulin-like growth factor-binding protein-like 1"]
["ENSRNOG00000024591",7,0.581186624,2,0.128660876,4.517197769,2.175428078,0.038372534,0.025824436,"up","yes","Hs3st3a1","protein_coding","chr10:49094026-49180676:+","gi|285026465|ref|NP_001165538.1|",1620,0,"heparan sulfate glucosamine 3-O-sulfotransferase 3A1 [Rattus norvegicus]","gi|285026464|ref|NM_001172067.1|",1198,0,"Rattus norvegicus heparan sulfate-glucosamine 3-sulfotransferase 3A1 (Hs3st3a1), mRNA","Q8BKN6",617,0,"Heparan sulfate glucosamine 3-O-sulfotransferase 3A1",".",".",".",".","pfam00685","Sulfotransfer_1","Sulfotransferase domain.",".","GO:0005794|Golgi apparatus;","GO:0008467|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity;","K07809","HS3ST3; [heparan sulfate]-glucosamine 3-sulfotransferase 3 [EC:2.8.2.30]"]
["ENSRNOG00000030738",7,0.581186624,2,0.128660876,4.517197769,2.175428078,0.038372534,0.025824436,"up","yes","ENSRNOG00000030738","protein_coding","chr9:94050573-94092832:-","gi|295391729|ref|NP_001171288.1|",2787,0,"uncharacterized protein LOC100362040 [Rattus norvegicus]","gi|295391728|ref|NM_001177817.1|",1770,0,"Rattus norvegicus Ac2-143-like (LOC100362040), mRNA",".",".",".",".",".",".",".",".","pfam11079","YqhG","Bacterial protein YqhG of unknown function. This family of putative proteins is conserved in the Bacillaceae family of the Firmicutes. The function is not known.",".",".",".",".","."]
["ENSRNOG00000038088",7,0.581186624,2,0.128660876,4.517197769,2.175428078,0.038372534,0.025824436,"up","yes","Nanos2","protein_coding","chr1:78635668-78637128:+","gi|157821141|ref|NP_001102378.1|",726,{"v":4e-91,"d":"4.00E-91"},"nanos homolog 2 [Rattus norvegicus]","gi|157821140|ref|NM_001108908.1|",1461,0,"Rattus norvegicus nanos homolog 2 (Drosophila) (Nanos2), mRNA","P60322",245,{"v":1e-77,"d":"1.00E-77"},"Nanos homolog 2",".",".",".",".","pfam05741","zf-nanos","Nanos RNA binding domain. This family consists of several conserved novel zinc finger domains found in the eukaryotic proteins Nanos and Xcat-2. In Drosophila melanogaster, Nanos functions as a localized determinant of posterior pattern. Nanos RNA is localized to the posterior pole of the maturing egg cell and encodes a protein that emanates from this localized source. Nanos acts as a translational repressor and thereby establishes a gradient of the morphogen Hunchback. Xcat-2 is found in the vegetal cortical region and is inherited by the vegetal blasomeres during development, and is degraded very early in development. The localized and maternally restricted expression of Xcat-2 RNA suggests a role for its protein in setting up regional differences in gene expression that occur early in development.","GO:0006402|mRNA catabolic process;GO:0007283|spermatogenesis;GO:0017148|negative regulation of translation;GO:0030718|germ-line stem cell population maintenance;GO:0045835|negative regulation of meiotic nuclear division;GO:0048477|oogenesis;GO:1900153|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;","GO:0000932|P-body;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0048471|perinuclear region of cytoplasm;","GO:0003729|mRNA binding;GO:0008270|zinc ion binding;","K18760","NANOS2, NOS2; protein nanos 2"]
["ENSRNOG00000038119",7,0.581186624,2,0.128660876,4.517197769,2.175428078,0.038372534,0.025824436,"up","yes","AABR07034706.1","protein_coding","chr11:81052095-81058321:+","gi|74141472|dbj|BAE43259.1|",364,{"v":6e-43,"d":"6.00E-43"},"unnamed protein product [Mus musculus]","gi|563319388|ref|NR_106695.1|",75,{"v":1e-29,"d":"1.00E-29"},"Rattus norvegicus microRNA 6323 (Mir6323), microRNA",".",".",".",".",".",".",".",".","pfam12982","DUF3866","Protein of unknown function (DUF3866). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 352 and 374 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000043390",7,0.581186624,2,0.128660876,4.517197769,2.175428078,0.038372534,0.025824436,"up","yes","ENSRNOG00000043390","protein_coding","chr7:84768254-85271766:-","gi|149066394|gb|EDM16267.1|",813,{"v":9E-103,"d":"9.00E-103"},"similar to sterile alpha motif domain containing 12 (predicted), isoform CRA_a [Rattus norvegicus]","gi|32362316|gb|AC115452.4|",1028,0,"Rattus norvegicus 7 BAC CH230-309G3 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam07647","SAM_2","SAM domain (Sterile alpha motif).","GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;","GO:0009898|cytoplasmic side of plasma membrane;",".",".","."]
["ENSRNOG00000062458",7,0.581186624,2,0.128660876,4.517197769,2.175428078,0.038372534,0.025824436,"up","yes","ENSRNOG00000062458","lncRNA","chr2:210344556-210345815:-",".",".",".",".","gi|672044090|ref|XR_591309.1|",558,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102555028 (LOC102555028), transcript variant X6, ncRNA",".",".",".",".",".",".",".",".","pfam10156","Med17","Subunit 17 of Mediator complex. This Mediator complex subunit was formerly known as Srb4 in yeasts or Trap80 in Drosophila and human. The Med17 subunit is located within the head domain and is essential for cell viability to the extent that a mutant strain of cerevisiae lacking it shows all RNA polymerase II-dependent transcription ceasing at non-permissive temperatures.",".",".",".",".","."]
["ENSRNOG00000064659",7,0.581186624,2,0.128660876,4.517197769,2.175428078,0.038372534,0.025824436,"up","yes","ENSRNOG00000064659","lncRNA","chr9:104733730-104755663:+",".",".",".",".","gi|33469210|gb|AC118608.7|",225,{"v":2e-112,"d":"2.00E-112"},"Mus musculus chromosome 17, clone RP23-478J10, complete sequence",".",".",".",".",".",".",".",".","pfam01956","DUF106","Integral membrane protein DUF106. This archaebacterial protein family has no known function. Members are predicted to be integral membrane proteins.",".",".",".",".","."]
["ENSRNOG00000066881",7,0.581186624,2,0.128660876,4.517197769,2.175428078,0.038372534,0.025824436,"up","yes","ENSRNOG00000066881","protein_coding","chr13:2852897-2854568:+","gi|24981047|gb|AAH39826.1|",846,{"v":8e-113,"d":"8.00E-113"},"DDX6 protein [Homo sapiens]","gi|672061649|ref|XM_006242954.2|",523,0,"PREDICTED: Rattus norvegicus DEAD (Asp-Glu-Ala-Asp) box helicase 6 (Ddx6), transcript variant X4, mRNA","P54823",335,{"v":7e-112,"d":"7.00E-112"},"Probable ATP-dependent RNA helicase DDX6",".",".",".",".","pfam00270","DEAD","DEAD/DEAH box helicase. Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolizm, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.",".",".",".",".","."]
["ENSRNOG00000070483",7,0.581186624,2,0.128660876,4.517197769,2.175428078,0.038372534,0.025824436,"up","yes","ENSRNOG00000070483","pseudogene","chr16:38886650-38887585:-","gi|556762898|ref|XP_005976738.1|",1291,{"v":2e-173,"d":"2.00E-173"},"PREDICTED: polyadenylate-binding protein 1 isoform X2 [Pantholops hodgsonii]","gi|672080136|ref|XR_596458.1|",471,0,"PREDICTED: Rattus norvegicus poly(A) binding protein, cytoplasmic 1, pseudogene 1 (Pabpc1-ps1), misc_RNA","Q9EPH8",499,{"v":1E-172,"d":"1.00E-172"},"Polyadenylate-binding protein 1",".",".",".",".","pfam00658","PABP","Poly-adenylate binding protein, unique domain. The region featured in this family is found towards the C-terminus of poly(A)-binding proteins (PABPs). These are eukaryotic proteins that, through their binding of the 3' poly(A) tail on mRNA, have very important roles in the pathways of gene expression. They seem to provide a scaffold on which other proteins can bind and mediate processes such as export, translation and turnover of the transcripts. Moreover, they may act as antagonists to the binding of factors that allow mRNA degradation, regulating mRNA longevity. PABPs are also involved in nuclear transport. PABPs interact with poly(A) tails via RNA-recognition motifs (pfam00076). Note that the PABP C-terminal region is also found in members of the hyperplastic discs protein (HYD) family of ubiquitin ligases that contain HECT domains - these are also included in this family.",".",".",".",".","."]
["ENSRNOG00000003304",16,1.328426568,9,0.578973944,2.29444966,1.198148155,0.041096485,0.027504207,"up","yes","Chad","protein_coding","chr10:79511931-79515940:+","gi|564373931|ref|XP_006247248.1|",1954,0,"PREDICTED: chondroadherin isoform X1 [Rattus norvegicus]","gi|9506482|ref|NM_019164.1|",1654,0,"Rattus norvegicus chondroadherin (Chad), mRNA","O70210",665,0,"Chondroadherin","SPy1798",61.2,7e-09,"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0001502|cartilage condensation;GO:0060348|bone development;GO:1900155|negative regulation of bone trabecula formation;","GO:0005615|extracellular space;GO:0016021|integral component of membrane;GO:0031012|extracellular matrix;",".","K06248","CHAD; chondroadherin"]
["ENSRNOG00000010015",16,1.328426568,9,0.578973944,2.29444966,1.198148155,0.041096485,0.027504207,"up","yes","Gp9","protein_coding","chr4:120235421-120237110:+","gi|73532774|ref|NP_001026995.1|",894,{"v":4e-118,"d":"4.00E-118"},"platelet glycoprotein IX precursor [Rattus norvegicus]","gi|71891592|dbj|AB158423.1|",570,0,"Rattus norvegicus Gp9 mRNA for glycoprotein 9, complete cds, strain:F344/DuCrj","O88186",293,{"v":4e-98,"d":"4.00E-98"},"Platelet glycoprotein IX",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.","GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;","K06263","GP9, CD42a; platelet glycoprotein IX"]
["ENSRNOG00000020380",16,1.328426568,9,0.578973944,2.29444966,1.198148155,0.041096485,0.027504207,"up","yes","Lgals7","protein_coding","chr1:84150252-84152015:+","gi|158517925|ref|NP_072104.2|",711,{"v":6e-92,"d":"6.00E-92"},"galectin-7 [Rattus norvegicus]","gi|672035697|ref|XM_006228670.2|",499,0,"PREDICTED: Rattus norvegicus lectin, galactoside-binding, soluble, 7 (Lgals7), transcript variant X2, mRNA","P97590",278,{"v":2e-93,"d":"2.00E-93"},"Galectin-7",".",".",".",".","pfam00337","Gal-bind_lectin","Galactoside-binding lectin. This family contains galactoside binding lectins.   The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).","GO:0006915|apoptotic process;GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0010628|positive regulation of gene expression;GO:0032689|negative regulation of interferon-gamma production;GO:2000562|negative regulation of CD4-positive, alpha-beta T cell proliferation;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005829|cytosol;","GO:0016936|galactoside binding;GO:0030246|carbohydrate binding;","K10092","LGALS7; galectin-7"]
["ENSRNOG00000031285",16,1.328426568,9,0.578973944,2.29444966,1.198148155,0.041096485,0.027504207,"up","yes","AABR07064305.1","protein_coding","chr6:71845227-71846354:-","gi|829951970|ref|XP_012600059.1|",867,{"v":9e-113,"d":"9.00E-113"},"PREDICTED: mitochondrial import inner membrane translocase subunit Tim23 isoform X2 [Microcebus murinus]","gi|53734358|gb|BC083559.1|",1070,0,"Rattus norvegicus translocase of inner mitochondrial membrane 23 homolog (yeast), mRNA (cDNA clone MGC:93478 IMAGE:7135081), complete cds","O35093",332,{"v":1e-111,"d":"1.00E-111"},"Mitochondrial import inner membrane translocase subunit Tim23","SPCC16A11.09c",62.4,{"v":2e-10,"d":"2.00E-10"},"COG5596","pfam02466","Tim17","Tim17/Tim22/Tim23/Pmp24 family. The pre-protein translocase of the mitochondrial outer membrane (Tom) allows the import of pre-proteins from the cytoplasm. Tom forms a complex with a number of proteins, including Tim17. Tim17 and Tim23 are thought to form the translocation channel of the inner membrane. This family includes Tim17, Tim22 and Tim23. This family also includes Pmp24 a peroxisomal protein. The involvement of this domain in the targeting of PMP24 remains to be proved. PMP24 was known as Pmp27 in.",".",".",".",".","."]
["ENSRNOG00000067378",11,0.913293266,5,0.321652191,2.839381455,1.50557668,0.04361789,0.028970325,"up","yes","ENSRNOG00000067378","protein_coding","chr10:52009425-52068951:+","gi|124486959|ref|NP_001074719.1|",9264,0,"myosin-13 [Mus musculus]","gi|672025636|ref|XM_008775758.1|",5161,0,"PREDICTED: Rattus norvegicus myosin-13 (LOC103693367), transcript variant X1, mRNA","Q9UKX3",3430,0,"Myosin-13","SPCC645.05c",729,0,"COG5022","pfam01576","Myosin_tail_1","Myosin tail. The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.",".",".",".",".","."]
["ENSRNOG00000006814",17,1.411453229,10,0.643304382,2.194067488,1.133607903,0.043966549,0.029162519,"up","yes","Klrg2","protein_coding","chr4:67363919-67374147:-","gi|293346733|ref|XP_002726391.1|",1706,0,"PREDICTED: killer cell lectin-like receptor subfamily G member 2 isoform X1 [Rattus norvegicus]","gi|672018159|ref|XM_002726345.3|",2175,0,"PREDICTED: Rattus norvegicus killer cell lectin-like receptor subfamily G, member 2 (Klrg2), transcript variant X1, mRNA","Q3UM83",569,0,"Killer cell lectin-like receptor subfamily G member 2",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000009736",17,1.411453229,10,0.643304382,2.194067488,1.133607903,0.043966549,0.029162519,"up","yes","A4galt","protein_coding","chr7:114368276-114396071:-","gi|564361254|ref|XP_006242177.1|",1970,0,"PREDICTED: lactosylceramide 4-alpha-galactosyltransferase isoform X2 [Rattus norvegicus]","gi|672060258|ref|XM_006242118.2|",2132,0,"PREDICTED: Rattus norvegicus alpha 1,4-galactosyltransferase (A4galt), transcript variant X2, mRNA","Q9JI93",751,0,"Lactosylceramide 4-alpha-galactosyltransferase",".",".",".",".","pfam04572","Gb3_synth","Alpha 1,4-glycosyltransferase conserved region. The glycosphingolipids (GSL) form part of eukaryotic cell membranes. They consist of a hydrophilic carbohydrate moiety linked to a hydrophobic ceramide tail embedded within the lipid bilayer of the membrane. Lactosylceramide, Gal1,4Glc1Cer (LacCer), is the common synthetic precursor to the majority of GSL found in vertebrates. Alpha 1.4-glycosyltransferases utilize UDP donors and transfer the sugar to a beta-linked acceptor. This region appears to be confined to higher eukaryotes. No function has been yet assigned to this region.","GO:0001576|globoside biosynthetic process;GO:0006688|glycosphingolipid biosynthetic process;GO:0007009|plasma membrane organization;","GO:0000139|Golgi membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0008378|galactosyltransferase activity;GO:0015643|toxic substance binding;GO:0016758|transferase activity, transferring hexosyl groups;GO:0050512|lactosylceramide 4-alpha-galactosyltransferase activity;","K01988","A4GALT; lactosylceramide 4-alpha-galactosyltransferase [EC:2.4.1.228]"]
["ENSRNOG00000021021",17,1.411453229,10,0.643304382,2.194067488,1.133607903,0.043966549,0.029162519,"up","yes","Ffar2","protein_coding","chr1:86072184-86075033:-","gi|54312092|ref|NP_001005877.1|",1636,0,"free fatty acid receptor 2 [Rattus norvegicus]","gi|672035674|ref|XM_006228821.2|",1709,0,"PREDICTED: Rattus norvegicus free fatty acid receptor 2 (Ffar2), transcript variant X1, mRNA","Q76EI6",634,0,"Free fatty acid receptor 2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0002232|leukocyte chemotaxis involved in inflammatory response;GO:0002385|mucosal immune response;GO:0002673|regulation of acute inflammatory response;GO:0002720|positive regulation of cytokine production involved in immune response;GO:0002752|cell surface pattern recognition receptor signaling pathway;GO:0002879|positive regulation of acute inflammatory response to non-antigenic stimulus;GO:0007186|G protein-coupled receptor signaling pathway;GO:0008150|biological_process;GO:0019915|lipid storage;GO:0032722|positive regulation of chemokine production;GO:0032757|positive regulation of interleukin-8 production;GO:0042593|glucose homeostasis;GO:0045444|fat cell differentiation;GO:0071398|cellular response to fatty acid;GO:0090276|regulation of peptide hormone secretion;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0042995|cell projection;","GO:0003674|molecular_function;GO:0004930|G protein-coupled receptor activity;GO:0008289|lipid binding;","K04328","FFAR2, GPR43; free fatty acid receptor 2"]
["ENSRNOG00000042781",17,1.411453229,10,0.643304382,2.194067488,1.133607903,0.043966549,0.029162519,"up","yes","Ropn1l","protein_coding","chr2:82441891-82453485:-","gi|300797558|ref|NP_001178015.1|",1058,{"v":8e-139,"d":"8.00E-139"},"ropporin-1-like protein [Rattus norvegicus]","gi|300797557|ref|NM_001191086.1|",762,0,"Rattus norvegicus rhophilin associated tail protein 1-like (Ropn1l), mRNA","Q9EQ00",380,{"v":6e-128,"d":"6.00E-128"},"Ropporin-1-like protein",".",".",".",".","pfam02197","RIIa","Regulatory subunit of type II PKA R-subunit.","GO:0001932|regulation of protein phosphorylation;GO:0003341|cilium movement;GO:0030317|flagellated sperm motility;GO:0048240|sperm capacitation;","GO:0005737|cytoplasm;GO:0005929|cilium;GO:0031514|motile cilium;","GO:0042802|identical protein binding;","K25457","ROPN1L; ropporin-1-like protein"]
["ENSRNOG00000070886",17,1.411453229,10,0.643304382,2.194067488,1.133607903,0.043966549,0.029162519,"up","yes","ENSRNOG00000070886","lncRNA","chr1:84971839-84972955:+","gi|532099919|ref|XP_005335591.1|",318,{"v":3e-66,"d":"3.00E-66"},"PREDICTED: ubiquitin-conjugating enzyme E2 N-like [Ictidomys tridecemlineatus]","gi|672013323|ref|XR_342836.2|",1105,0,"PREDICTED: Rattus norvegicus ubiquitin-conjugating enzyme E2 N-like (LOC100909892), transcript variant X1, misc_RNA","Q9EQX9",143,{"v":3e-63,"d":"3.00E-63"},"Ubiquitin-conjugating enzyme E2 N","YDR092w",100,{"v":2e-24,"d":"2.00E-24"},"COG5078","pfam00179","UQ_con","Ubiquitin-conjugating enzyme. Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. TSG101 is one of several UBC homologues that lacks this active site cysteine.",".",".",".",".","."]
["ENSRNOG00000002350",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","Eaf2","protein_coding","chr11:63960200-64004610:+","gi|25282431|ref|NP_742044.1|",1098,{"v":5e-147,"d":"5.00E-147"},"ELL-associated factor 2 [Rattus norvegicus]","gi|25282430|ref|NM_172047.1|",1104,0,"Rattus norvegicus ELL associated factor 2 (Eaf2), mRNA","Q811X5",407,{"v":9e-141,"d":"9.00E-141"},"ELL-associated factor 2",".",".",".",".","pfam09816","EAF","RNA polymerase II transcription elongation factor. Members of this family act as transcriptional transactivators of ELL and ELL2 elongation activities. Eaf proteins form a stable heterodimer complex with ELL proteins to facilitate the binding of RNA polymerase II to activate transcription elongation. The N-terminus of approx 120 residues is globular and highly conserved.","GO:0006915|apoptotic process;GO:0008150|biological_process;GO:0030308|negative regulation of cell growth;GO:0034243|regulation of transcription elongation from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0060770|negative regulation of epithelial cell proliferation involved in prostate gland development;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0008023|transcription elongation factor complex;GO:0016607|nuclear speck;GO:0032783|ELL-EAF complex;","GO:0003674|molecular_function;GO:0003711|transcription elongation regulator activity;","K15186","EAF; ELL-associated factor"]
["ENSRNOG00000006146",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","Trim54","protein_coding","chr6:25239340-25258511:-","gi|61557310|ref|NP_001013235.1|",1563,0,"tripartite motif-containing protein 54 [Rattus norvegicus]","gi|61557309|ref|NM_001013217.1|",1065,0,"Rattus norvegicus tripartite motif-containing 54 (Trim54), mRNA","Q5XIH6",606,0,"Tripartite motif-containing protein 54",".",".",".",".","pfam00643","zf-B_box","B-box zinc finger.","GO:0007026|negative regulation of microtubule depolymerization;GO:0016567|protein ubiquitination;GO:0030154|cell differentiation;","GO:0005737|cytoplasm;GO:0005874|microtubule;GO:0005875|microtubule associated complex;GO:0030018|Z disc;","GO:0008017|microtubule binding;GO:0008270|zinc ion binding;GO:0061630|ubiquitin protein ligase activity;","K10653","TRIM54, MURF3; tripartite motif-containing protein 54"]
["ENSRNOG00000009160",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","AABR07073350.1","pseudogene","chr7:132740198-132743815:-","gi|54607171|ref|NP_032502.3|",1361,{"v":9e-180,"d":"9.00E-180"},"keratin, type II cytoskeletal 6A [Mus musculus]","gi|155369695|ref|NM_001101007.1|",925,0,"Rattus norvegicus similar to keratin complex 2, basic, gene 6a (LOC683313), mRNA","P50446",528,0,"Keratin, type II cytoskeletal 6A",".",".",".",".","pfam00038","Filament","Intermediate filament protein.",".",".",".",".","."]
["ENSRNOG00000011171",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","Rims3","protein_coding","chr5:134435829-134640489:+","gi|589949311|ref|XP_006987313.1|",1445,0,"PREDICTED: regulating synaptic membrane exocytosis protein 3 [Peromyscus maniculatus bairdii]","gi|12621089|ref|NM_022931.1|",1565,0,"Rattus norvegicus regulating synaptic membrane exocytosis 3 (Rims3), mRNA","Q9JIR3",556,0,"Regulating synaptic membrane exocytosis protein 3",".",".",".",".","pfam00168","C2","C2 domain.","GO:0006836|neurotransmitter transport;GO:0006887|exocytosis;GO:0017156|calcium ion regulated exocytosis;GO:0042391|regulation of membrane potential;GO:0048167|regulation of synaptic plasticity;GO:0048791|calcium ion-regulated exocytosis of neurotransmitter;GO:0050806|positive regulation of synaptic transmission;GO:0050807|regulation of synapse organization;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0016020|membrane;GO:0042734|presynaptic membrane;GO:0048788|cytoskeleton of presynaptic active zone;GO:0098978|glutamatergic synapse;GO:0099524|postsynaptic cytosol;","GO:0031267|small GTPase binding;GO:0044325|ion channel binding;","K15298","RIMS3, RIM3; regulating synaptic membrane exocytosis protein 3"]
["ENSRNOG00000011500",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","Pou2af1","protein_coding","chr8:51474015-51548819:+","gi|672062244|ref|XP_008764563.1|",1192,{"v":4e-154,"d":"4.00E-154"},"PREDICTED: POU domain class 2-associating factor 1 isoform X1 [Rattus norvegicus]","gi|672062243|ref|XM_008766341.1|",2417,0,"PREDICTED: Rattus norvegicus POU class 2 associating factor 1 (Pou2af1), transcript variant X1, mRNA","Q64693",449,{"v":2E-150,"d":"2.00E-150"},"POU domain class 2-associating factor 1",".",".",".",".","pfam09310","PD-C2-AF1","POU domain, class 2, associating factor 1. Members of this family are transcriptional coactivators that specifically associate with either OCT1 or OCT2, through recognition of their POU domains. They are essential for the response of B-cells to antigens and required for the formation of germinal centres.","GO:0002314|germinal center B cell differentiation;GO:0032755|positive regulation of interleukin-6 production;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0098586|cellular response to virus;","GO:0090575|RNA polymerase II transcription factor complex;","GO:0003677|DNA binding;GO:0003713|transcription coactivator activity;",".","."]
["ENSRNOG00000012697",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","Spaca9","protein_coding","chr3:12019363-12029119:-","gi|564339913|ref|XP_006233824.1|",1345,{"v":1E-180,"d":"1.00E-180"},"PREDICTED: uncharacterized protein C9orf9 homolog isoform X1 [Rattus norvegicus]","gi|564339912|ref|XM_006233762.1|",999,0,"PREDICTED: Rattus norvegicus Rsb-66 protein (Rsb66), transcript variant X1, mRNA","Q96E40",362,{"v":3e-120,"d":"3.00E-120"},"Sperm acrosome-associated protein 9",".",".",".",".","pfam15120","DUF4561","Domain of unknown function (DUF4561). This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes.",".","GO:0001669|acrosomal vesicle;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005881|cytoplasmic microtubule;GO:0036064|ciliary basal body;GO:0036126|sperm flagellum;GO:0097546|ciliary base;","GO:0005515|protein binding;GO:0048306|calcium-dependent protein binding;","K25516","SPACA9; sperm acrosome membrane-associated protein 9"]
["ENSRNOG00000016999",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","Grp","protein_coding","chr18:59388274-59402061:+","gi|291327531|ref|NP_598254.2|",704,{"v":2e-88,"d":"2.00E-88"},"gastrin-releasing peptide preproprotein [Rattus norvegicus]","gi|204256|gb|M31176.1|RATGASRP",1252,0,"Rat gastrin-releasing peptide mRNA, complete cds","P24393",275,{"v":8E-90,"d":"8.00E-90"},"Gastrin-releasing peptide",".",".",".",".","pfam02044","Bombesin","Bombesin-like peptide.","GO:0007218|neuropeptide signaling pathway;GO:0035176|social behavior;GO:0036343|psychomotor behavior;GO:0043207|response to external biotic stimulus;GO:0090277|positive regulation of peptide hormone secretion;GO:1900738|positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway;","GO:0005615|extracellular space;GO:0034774|secretory granule lumen;","GO:0005184|neuropeptide hormone activity;","K05224","GRP; gastrin-releasing peptide"]
["ENSRNOG00000019176",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","Kcne5","protein_coding","chrX:105930398-105931013:-","gi|26380608|dbj|BAC25441.1|",416,{"v":5e-59,"d":"5.00E-59"},"unnamed protein product [Mus musculus]","gi|155369687|ref|NM_001101003.1|",616,0,"Rattus norvegicus potassium voltage-gated channel subfamily E regulatory subunit 5 (Kcne5), mRNA","Q9QZ26",185,{"v":7e-58,"d":"7.00E-58"},"Potassium voltage-gated channel subfamily E regulatory beta subunit 5",".",".",".",".","pfam07271","Cytadhesin_P30","Cytadhesin P30/P32. This family consists of several Mycoplasma species specific Cytadhesin P32 and P30 proteins. P30 has been found to be membrane associated and localized on the tip organelle. It is thought that it is important in cytadherence and virulence.","GO:0008016|regulation of heart contraction;GO:0008150|biological_process;GO:0060048|cardiac muscle contraction;GO:0060306|regulation of membrane repolarization;GO:0060307|regulation of ventricular cardiac muscle cell membrane repolarization;GO:0060372|regulation of atrial cardiac muscle cell membrane repolarization;GO:0086005|ventricular cardiac muscle cell action potential;GO:0086011|membrane repolarization during action potential;GO:0086014|atrial cardiac muscle cell action potential;GO:0086091|regulation of heart rate by cardiac conduction;GO:0097623|potassium ion export across plasma membrane;GO:0098915|membrane repolarization during ventricular cardiac muscle cell action potential;GO:1901379|regulation of potassium ion transmembrane transport;GO:1901380|negative regulation of potassium ion transmembrane transport;GO:1901381|positive regulation of potassium ion transmembrane transport;GO:1902260|negative regulation of delayed rectifier potassium channel activity;GO:1903765|negative regulation of potassium ion export across plasma membrane;GO:2001257|regulation of cation channel activity;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0008076|voltage-gated potassium channel complex;","GO:0003674|molecular_function;GO:0005249|voltage-gated potassium channel activity;GO:0005251|delayed rectifier potassium channel activity;GO:0015459|potassium channel regulator activity;GO:0044325|ion channel binding;GO:0086008|voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization;GO:1902282|voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization;","K04895","KCNE1L; potassium voltage-gated channel Isk-related subfamily E member 1-like"]
["ENSRNOG00000024878",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","Rbm44","protein_coding","chr9:91731115-91756772:+","gi|109486365|ref|XP_576610.2|",5310,0,"PREDICTED: RNA-binding protein 44 [Rattus norvegicus]","gi|672024304|ref|XM_001066845.5|",4177,0,"PREDICTED: Rattus norvegicus RNA binding motif protein 44 (Rbm44), transcript variant X1, mRNA","D3Z987",2019,0,"RNA-binding protein 44",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.",".","GO:0005737|cytoplasm;GO:0045171|intercellular bridge;","GO:0003723|RNA binding;GO:0042803|protein homodimerization activity;","K25080","RBM44; RNA-binding protein 44"]
["ENSRNOG00000028765",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","Ttc24","protein_coding","chr2:173524600-173533107:-","gi|564300525|ref|XP_006224230.1|",2578,0,"PREDICTED: tetratricopeptide repeat protein 24 isoform X1 [Rattus norvegicus]","gi|672015944|ref|XM_006224168.2|",2022,0,"PREDICTED: Rattus norvegicus tetratricopeptide repeat domain 24 (Ttc24), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam03154","Atrophin-1","Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.",".",".",".",".","."]
["ENSRNOG00000029637",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","Acot6","protein_coding","chr6:103732372-103741446:+","gi|765826426|ref|NP_001292214.1|",2068,0,"acyl-coenzyme A thioesterase 6 [Rattus norvegicus]","gi|765826425|ref|NM_001305285.1|",1578,0,"Rattus norvegicus acyl-CoA thioesterase 6 (Acot6), mRNA","Q32Q92",668,0,"Acyl-coenzyme A thioesterase 6","RSc1887_1",137,{"v":1e-34,"d":"1.00E-34"},"COG1073","pfam08840","BAAT_C","BAAT / Acyl-CoA thioester hydrolase C terminal. This catalytic domain is found at the C terminal of acyl-CoA thioester hydrolases and bile acid-CoA:amino acid N-acetyltransferases (BAAT).","GO:0006631|fatty acid metabolic process;GO:0006637|acyl-CoA metabolic process;","GO:0005829|cytosol;","GO:0047617|acyl-CoA hydrolase activity;","K11993","ACOT6; acyl-CoA thioesterase 6 [EC:3.1.2.-]"]
["ENSRNOG00000031823",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","Wfdc6b","protein_coding","chr3:153339110-153347132:+","gi|57114312|ref|NP_001008867.1|",966,{"v":2E-131,"d":"2.00E-131"},"WAP four-disulfide core domain protein 6B precursor [Rattus norvegicus]","gi|57114311|ref|NM_001008867.1|",549,0,"Rattus norvegicus WAP four-disulfide core domain 6B (Wfdc6b), mRNA","F6ULY1",219,{"v":2e-71,"d":"2.00E-71"},"WAP four-disulfide core domain protein 6B",".",".",".",".","pfam00014","Kunitz_BPTI","Kunitz/Bovine pancreatic trypsin inhibitor domain. Indicative of a protease inhibitor, usually a serine protease inhibitor. Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure. Certain family members are similar to the tick anticoagulant peptide (TAP). This is a highly selective inhibitor of factor Xa in the blood coagulation pathways. TAP molecules are highly dipolar, and are arranged to form a twisted two- stranded antiparallel beta-sheet followed by an alpha helix.","GO:0010466|negative regulation of peptidase activity;GO:0010951|negative regulation of endopeptidase activity;","GO:0005615|extracellular space;","GO:0004867|serine-type endopeptidase inhibitor activity;","K23640","WFDC6; WAP four-disulfide core domain protein 6"]
["ENSRNOG00000035636",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","Mirlet7b","miRNA","chr7:116804186-116804270:+",".",".",".",".","gi|296923659|ref|NR_031802.1|",85,{"v":9e-36,"d":"9.00E-36"},"Rattus norvegicus microRNA let-7b (Mirlet7b), microRNA",".",".",".",".",".",".",".",".","pfam05704","Caps_synth","Capsular polysaccharide synthesis protein. This family consists of several capsular polysaccharide proteins. Capsular polysaccharide (CPS) is a major virulence factor in Streptococcus pneumoniae.","GO:0006402|mRNA catabolic process;GO:0007566|embryo implantation;GO:0007569|cell aging;GO:0009617|response to bacterium;GO:0030509|BMP signaling pathway;GO:0035195|gene silencing by miRNA;GO:0035278|miRNA mediated inhibition of translation;GO:0070482|response to oxygen levels;","GO:0016442|RISC complex;",".","K16980","MIRLET7; microRNA let-7"]
["ENSRNOG00000039325",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","Grxcr2","protein_coding","chr18:33984689-33998094:-","gi|300797390|ref|NP_001178007.1|",1325,0,"glutaredoxin domain-containing cysteine-rich protein 2 [Rattus norvegicus]","gi|300797389|ref|NM_001191078.1|",1166,0,"Rattus norvegicus glutaredoxin, cysteine rich 2 (Grxcr2), mRNA","Q3TYR5",484,{"v":9e-171,"d":"9.00E-171"},"Glutaredoxin domain-containing cysteine-rich protein 2",".",".",".",".","pfam00684","DnaJ_CXXCXGXG","DnaJ central domain. The central cysteine-rich (CR) domain of DnaJ proteins contains four repeats of the motif CXXCXGXG where X is any amino acid. The isolated cysteine rich domain folds in zinc dependent fashion. Each set of two repeats binds one unit of zinc. Although this domain has been implicated in substrate binding, no evidence of specific interaction between the isolated DNAJ cysteine rich domain and various hydrophobic peptides has been found.","GO:0007605|sensory perception of sound;GO:0033365|protein localization to organelle;GO:0060088|auditory receptor cell stereocilium organization;GO:0060122|inner ear receptor cell stereocilium organization;","GO:0005902|microvillus;GO:0120043|stereocilium shaft;GO:0120044|stereocilium base;",".","K24294","GRXCR2; glutaredoxin domain-contaning cysteine-rich protein 2"]
["ENSRNOG00000042041",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","Gal3st1","protein_coding","chr14:78870793-78886388:+","gi|157821431|ref|NP_001102917.1|",2283,0,"galactosylceramide sulfotransferase [Rattus norvegicus]","gi|157821430|ref|NM_001109447.1|",1858,0,"Rattus norvegicus galactose-3-O-sulfotransferase 1 (Gal3st1), mRNA","Q9JHE4",798,0,"Galactosylceramide sulfotransferase",".",".",".",".","pfam06990","Gal-3-0_sulfotr","Galactose-3-O-sulfotransferase. This family consists of several mammalian galactose-3-O-sulfotransferase proteins. Gal-3-O-sulfotransferase is thought to play a critical role in 3'-sulfation of N-acetyllactosamine in both O- and N-glycans.","GO:0006665|sphingolipid metabolic process;GO:0006681|galactosylceramide metabolic process;GO:0006682|galactosylceramide biosynthetic process;GO:0007283|spermatogenesis;GO:0042552|myelination;GO:0046486|glycerolipid metabolic process;","GO:0016021|integral component of membrane;","GO:0001733|galactosylceramide sulfotransferase activity;GO:0008146|sulfotransferase activity;GO:0050694|galactose 3-O-sulfotransferase activity;","K01019","GAL3ST1; galactosylceramide sulfotransferase [EC:2.8.2.11]"]
["ENSRNOG00000042407",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","Obp2a","protein_coding","chr3:8505990-8509269:+","gi|189458872|ref|NP_001121611.1|",829,{"v":1e-109,"d":"1.00E-109"},"odorant binding protein 2A precursor [Rattus norvegicus]","gi|402693461|ref|NM_001128139.2|",698,0,"Rattus norvegicus odorant binding protein 2A (Obp2a), mRNA","Q8K1H9",222,{"v":3e-71,"d":"3.00E-71"},"Odorant-binding protein 2a",".",".",".",".","pfam00061","Lipocalin","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.","GO:0008286|insulin receptor signaling pathway;GO:0010906|regulation of glucose metabolic process;GO:0032000|positive regulation of fatty acid beta-oxidation;GO:0042593|glucose homeostasis;GO:0045721|negative regulation of gluconeogenesis;GO:0051055|negative regulation of lipid biosynthetic process;","GO:0005615|extracellular space;","GO:0036094|small molecule binding;","K25352","OBP2; odorant-binding protein 2"]
["ENSRNOG00000046764",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","Tmprss11a","protein_coding","chr14:21606547-21665279:+","gi|672027772|ref|XP_008763396.1|",2199,0,"PREDICTED: transmembrane protease serine 11A isoform X1 [Rattus norvegicus]","gi|672027771|ref|XM_008765174.1|",2741,0,"PREDICTED: Rattus norvegicus transmembrane protease, serine 11A (Tmprss11a), transcript variant X1, mRNA","Q3UQ41",736,0,"Transmembrane protease serine 11A","VC1200",110,{"v":8e-25,"d":"8.00E-25"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;","GO:0016021|integral component of membrane;","GO:0004252|serine-type endopeptidase activity;","K09750","TMPRSS11A; transmembrane protease serine 11A [EC:3.4.21.-]"]
["ENSRNOG00000049407",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","Shisa8","protein_coding","chr7:113722408-113727858:-","gi|333108271|ref|NP_001193951.1|",1080,{"v":2e-138,"d":"2.00E-138"},"putative protein shisa-8 precursor [Rattus norvegicus]","gi|333108270|ref|NM_001207022.1|",1897,0,"Rattus norvegicus shisa family member 8 (Shisa8), mRNA","J3QNX5",407,{"v":7e-135,"d":"7.00E-135"},"Protein shisa-8",".",".",".",".","pfam13908","Shisa","Wnt and FGF inhibitory regulator. Shisa is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface.","GO:0048172|regulation of short-term neuronal synaptic plasticity;GO:2000311|regulation of AMPA receptor activity;","GO:0014069|postsynaptic density;GO:0032281|AMPA glutamate receptor complex;GO:0032591|dendritic spine membrane;GO:0045211|postsynaptic membrane;",".",".","."]
["ENSRNOG00000050672",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","Ervfrd-1","protein_coding","chr12:22151211-22158264:+","gi|62821770|ref|NP_001014771.1|",3134,0,"envelope glycoprotein syncytin-A precursor [Rattus norvegicus]","gi|333033801|ref|NM_001014771.2|",3102,0,"Rattus norvegicus syncytin a (Syna), mRNA","Q5G5D5",1089,0,"Syncytin-A",".",".",".",".","pfam00429","TLV_coat","ENV polyprotein (coat polyprotein).","GO:0000768|syncytium formation by plasma membrane fusion;GO:0006949|syncytium formation;GO:0007520|myoblast fusion;GO:0060711|labyrinthine layer development;","GO:0016021|integral component of membrane;",".","K24396","ERVFRD-1; syncytin-2"]
["ENSRNOG00000050998",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","AABR07044397.1","protein_coding","chr20:2496605-2497428:-","gi|3493251|gb|AAC33333.1|",477,{"v":2e-58,"d":"2.00E-58"},"MHC class I antigen [Rattus norvegicus]","gi|428673555|ref|NG_004563.4|",469,0,"Rattus norvegicus RT1 class I, locus V2, pseudogene 1 (RT1-V2-ps1) on chromosome 20","P01895",167,{"v":2e-49,"d":"2.00E-49"},"H-2 class I histocompatibility antigen, alpha chain (Fragment)",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.",".",".",".",".","."]
["ENSRNOG00000051208",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","Selenov","protein_coding","chr1:83551473-83558756:-","gi|261862293|ref|NP_001159868.1|",1264,{"v":1e-170,"d":"1.00E-170"},"selenoprotein V [Rattus norvegicus]","gi|261862292|ref|NM_001166396.1|",1193,0,"Rattus norvegicus selenoprotein V (Selv), mRNA",".",".",".",".",".",".",".",".","pfam10262","Rdx","Rdx family. This entry is an approximately 100 residue region of selenoprotein-T, conserved from plants to humans. The protein binds to UDP-glucose:glycoprotein glucosyltransferase (UGTR), the endoplasmic reticulum (ER)-resident protein, which is known to be involved in the quality control of protein folding. Selenium (Se) plays an essential role in cell survival and most of the effects of Se are probably mediated by selenoproteins, including selenoprotein T. However, despite its binding to UGTR and that its mRNA is up-regulated in extended asphyxia, the function of the protein and hence of this region of it is unknown. Selenoprotein W contains selenium as selenocysteine in the primary protein structure and levels of this selenoprotein are affected by selenium.","GO:0010269|response to selenium ion;","GO:0005829|cytosol;",".",".","."]
["ENSRNOG00000054142",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","Slc30a2","protein_coding","chr5:146559733-146571956:+","gi|133908626|ref|NP_001076591.1|",1842,0,"zinc transporter 2 isoform 1 [Rattus norvegicus]","gi|133908625|ref|NM_001083122.1|",3088,0,"Rattus norvegicus solute carrier family 30 (zinc transporter), member 2 (Slc30a2), transcript variant 1, mRNA","Q2HJ10",682,0,"Zinc transporter 2","lin2720",154,{"v":6e-40,"d":"6.00E-40"},"COG1230","pfam01545","Cation_efflux","Cation efflux family. Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells.","GO:0006829|zinc ion transport;GO:0010043|response to zinc ion;GO:0061088|regulation of sequestering of zinc ion;GO:0061090|positive regulation of sequestering of zinc ion;GO:0071577|zinc ion transmembrane transport;GO:0098655|cation transmembrane transport;","GO:0005737|cytoplasm;GO:0005770|late endosome;GO:0005886|plasma membrane;GO:0010008|endosome membrane;GO:0016021|integral component of membrane;GO:0031410|cytoplasmic vesicle;GO:0043231|intracellular membrane-bounded organelle;","GO:0005385|zinc ion transmembrane transporter activity;GO:0008324|cation transmembrane transporter activity;GO:0042802|identical protein binding;","K14689","SLC30A2, ZNT2; solute carrier family 30 (zinc transporter), member 2"]
["ENSRNOG00000055496",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","ENSRNOG00000055496","protein_coding","chr8:20757584-20772663:-","gi|564362750|ref|XP_006242762.1|",2949,0,"PREDICTED: zinc finger protein OZF-like [Rattus norvegicus]","gi|672061169|ref|XM_006242700.2|",2378,0,"PREDICTED: Rattus norvegicus zinc finger protein OZF-like (LOC103690166), transcript variant X2, mRNA","P17030",403,{"v":2e-130,"d":"2.00E-130"},"Zinc finger protein 25",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".","GO:0046872|metal ion binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSRNOG00000056476",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","Slc22a13","protein_coding","chr8:118922367-118953635:-","gi|187282171|ref|NP_001119757.1|",2750,0,"solute carrier family 22 member 13 [Rattus norvegicus]","gi|187282170|ref|NM_001126285.1|",1974,0,"Rattus norvegicus solute carrier family 22 member 13 (Slc22a13), mRNA","Q6A4L0",945,0,"Solute carrier family 22 member 13",".",".",".",".","pfam00083","Sugar_tr","Sugar (and other) transporter.","GO:0008150|biological_process;GO:0055085|transmembrane transport;","GO:0005575|cellular_component;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0022857|transmembrane transporter activity;","K08209","SLC22A13; MFS transporter, OCT family, solute carrier family 22 (organic cation transporter), member 13"]
["ENSRNOG00000059108",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","U7","snRNA","chr17:43105460-43105522:+",".",".",".",".","gi|351735276|emb|AL589742.22|",51,{"v":4e-17,"d":"4.00E-17"},"Mouse DNA sequence from clone RP23-298F22 on chromosome 13, complete sequence",".",".",".",".",".",".",".",".","pfam12781","AAA_9","ATP-binding dynein motor region D5. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D5 ATP-binding region of the motor, but has lost its P-loop.",".",".",".",".","."]
["ENSRNOG00000062472",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","ENSRNOG00000062472","lncRNA","chr19:13758706-13763770:+","gi|672085014|ref|XP_008770772.1|",650,{"v":1e-75,"d":"1.00E-75"},"PREDICTED: uncharacterized protein LOC363324 isoform X3 [Rattus norvegicus]","gi|672085013|ref|XM_008772550.1|",483,0,"PREDICTED: Rattus norvegicus similar to spermatogenesis associated glutamate (E)-rich protein 4d (LOC363324), transcript variant X3, mRNA","P03365",93.6,{"v":3e-18,"d":"3.00E-18"},"Gag-Pro-Pol polyprotein",".",".",".",".","pfam00665","rve","Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyses the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.",".",".",".",".","."]
["ENSRNOG00000063382",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","ENSRNOG00000063382","lncRNA","chr9:38502744-38512873:+","gi|149046391|gb|EDL99284.1|",244,{"v":7e-22,"d":"7.00E-22"},"rCG22167 [Rattus norvegicus]","gi|59958554|gb|AC132456.5|",198,{"v":4e-97,"d":"4.00E-97"},"Mus musculus BAC clone RP23-134L6 from 1, complete sequence",".",".",".",".",".",".",".",".","pfam12831","FAD_oxidored","FAD dependent oxidoreductase. This family of proteins contains FAD dependent oxidoreductases and related proteins.",".",".",".",".","."]
["ENSRNOG00000064002",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","ENSRNOG00000064002","protein_coding","chr2:5268578-5270273:-","gi|31077128|ref|NP_852036.1|",702,{"v":4E-90,"d":"4.00E-90"},"glutathione S-transferase kappa 1 [Rattus norvegicus]","gi|564334619|ref|XR_351234.1|",529,0,"PREDICTED: Rattus norvegicus glutathione S-transferase kappa 1-like (LOC102549076), misc_RNA","P24473",275,{"v":1E-91,"d":"1.00E-91"},"Glutathione S-transferase kappa 1","PA0118",50.8,3e-07,"COG3917","pfam01323","DSBA","DSBA-like thioredoxin domain. This family contains a diverse set of proteins with a thioredoxin-like structure pfam00085. This family also includes 2-hydroxychromene-2-carboxylate (HCCA) isomerase enzymes catalyse one step in prokaryotic polyaromatic hydrocarbon (PAH) catabolic pathways. This family also contains members with functions other than HCCA isomerization, such as Kappa family GSTs, whose similarity to HCCA isomerases was not previously recognized. Some member sequences have been annotated as a dioxygenases, dehydrogenases, and putative glycerol-3-phosphate transfer proteins, but are most likely HCCA isomerase enzymes.",".",".",".",".","."]
["ENSRNOG00000064011",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","Hist1h2bq","protein_coding","chr17:41562508-41562963:+","gi|826277509|ref|XP_012494077.1|",480,{"v":5e-59,"d":"5.00E-59"},"PREDICTED: histone H2B type 1-like [Propithecus coquereli]","gi|672081877|ref|XM_008771682.1|",453,0,"PREDICTED: Rattus norvegicus histone cluster 1, H2bd-like (LOC100365043), mRNA","Q93079",189,{"v":3e-60,"d":"3.00E-60"},"Histone H2B type 1-H",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.",".",".",".",".","."]
["ENSRNOG00000064216",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","ENSRNOG00000064216","lncRNA","chr17:32635663-32644450:-",".",".",".",".","gi|672081637|ref|XR_360982.2|",2087,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102555591 (LOC102555591), ncRNA",".",".",".",".",".",".",".",".","pfam12296","HsbA","Hydrophobic surface binding protein A. This protein is found in eukaryotes. Proteins in this family are typically between 171 to 275 amino acids in length. Although the HsbA amino acid sequence suggests that HsbA may be hydrophilic, HsbA adsorbed to hydrophobic PBSA (Polybutylene succinate-co-adipate) surfaces in the presence of NaCl or CaCl2. When HsbA was adsorbed on the hydrophobic PBSA surfaces, it promoted PBSA degradation via the CutL1 polyesterase. CutL1 interacts directly with HsbA attached to the hydrophobic QCM electrode surface. These results suggest that when HsbA is adsorbed onto the PBSA surface, it recruits CutL1, and that when CutL1 is accumulated on the PBSA surface, it stimulates PBSA degradation.",".",".",".",".","."]
["ENSRNOG00000065642",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","ENSRNOG00000065642","lncRNA","chr1:137792043-137853561:+",".",".",".",".","gi|68051863|gb|AC154141.7|",419,0,"Mus musculus chromosome 7, clone RP24-343G19, complete sequence",".",".",".",".",".",".",".",".","pfam10131","PTPS_related","6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein. This domain is found in various bacterial hypothetical membrane proteins, as well as in tetratricopeptide TPR_2 repeat protein. The exact function of the domain has not, as yet, been established.",".",".",".",".","."]
["ENSRNOG00000065924",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","ENSRNOG00000065924","protein_coding","chrX:1386155-1386850:+","gi|635137880|ref|XP_008015806.1|",948,{"v":6e-127,"d":"6.00E-127"},"PREDICTED: 60S ribosomal protein L9 [Chlorocebus sabaeus]","gi|672035359|ref|XM_003748774.3|",633,0,"PREDICTED: Rattus norvegicus ribosomal protein L9-like (LOC100364457), mRNA","P17077",366,{"v":7E-128,"d":"7.00E-128"},"60S ribosomal protein L9","SPAC4G9.16c",184,{"v":8e-57,"d":"8.00E-57"},"COG0097","pfam00347","Ribosomal_L6","Ribosomal protein L6.",".",".",".",".","."]
["ENSRNOG00000066094",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","ENSRNOG00000066094","protein_coding","chr1:66638117-66656976:+","gi|672013049|ref|XP_008772623.1|",4883,0,"PREDICTED: zinc finger protein 271-like isoform X2 [Rattus norvegicus]","gi|672013048|ref|XM_008774401.1|",2942,0,"PREDICTED: Rattus norvegicus similar to zinc finger protein 418 (LOC691135), transcript variant X2, mRNA","A8MQ14",674,0,"Zinc finger protein 850",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000066136",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","ENSRNOG00000066136","lncRNA","chr2:196188993-196190018:+","gi|149025702|gb|EDL81945.1|",195,{"v":3e-16,"d":"3.00E-16"},"rCG28799 [Rattus norvegicus]","gi|354789192|gb|JN953693.1|",314,{"v":8e-162,"d":"8.00E-162"},"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Tmem167b:tm1e(EUCOMM)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam06070","Herpes_UL32","Herpesvirus large structural phosphoprotein UL32. The large phosphorylated protein (UL32-like) of herpes viruses is the polypeptide most frequently reactive in immuno-blotting analyses with antisera when compared with other viral proteins.",".",".",".",".","."]
["ENSRNOG00000066186",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","ENSRNOG00000066186","pseudogene","chr5:53163276-53165288:-","gi|831237725|ref|XP_012665030.1|",1910,0,"PREDICTED: heat shock cognate 71 kDa protein [Otolemur garnettii]","gi|672070446|ref|XR_594968.1|",1023,0,"PREDICTED: Rattus norvegicus similar to heat shock protein 8 (LOC680121), misc_RNA","P63018",584,0,"Heat shock cognate 71 kDa protein","SPAC13G7.02c",424,{"v":2E-140,"d":"2.00E-140"},"COG0443","pfam00012","HSP70","Hsp70 protein. Hsp70 chaperones help to fold many proteins. Hsp70 assisted folding involves repeated cycles of substrate binding and release. Hsp70 activity is ATP dependent. Hsp70 proteins are made up of two regions: the amino terminus is the ATPase domain and the carboxyl terminus is the substrate binding region.",".",".",".",".","."]
["ENSRNOG00000066608",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","ENSRNOG00000066608","protein_coding","chr9:91765563-91806392:+","gi|270309174|ref|NP_001161864.1|",268,{"v":4e-23,"d":"4.00E-23"},"receptor activity-modifying protein 1 isoform 3 precursor [Mus musculus]","gi|51699733|gb|AC102874.7|",1774,0,"Mus musculus chromosome 1, clone RP24-500O1, complete sequence","Q9JJ74",103,{"v":2e-22,"d":"2.00E-22"},"Receptor activity-modifying protein 1",".",".",".",".","pfam04901","RAMP","Receptor activity modifying family. The calcitonin-receptor-like receptor can function as either a calcitonin-gene-related peptide or an adrenomedullin receptor. The receptors function is modified by receptor-activity-modifying protein or RAMP. RAMPs are single-transmembrane-domain proteins.",".",".",".",".","."]
["ENSRNOG00000066977",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","ENSRNOG00000066977","protein_coding","chr8:108236754-108241065:-","gi|148689252|gb|EDL21199.1|",462,{"v":4E-51,"d":"4.00E-51"},"mCG146219, partial [Mus musculus]","gi|672023321|ref|XR_348734.2|",958,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102551360 (LOC102551360), transcript variant X2, ncRNA","Q9WVF8",69.7,{"v":1e-12,"d":"1.00E-12"},"Tumor suppressor candidate 2",".",".",".",".","pfam15000","TUSC2","tumor suppressor candidate 2. This family of proteins are candidate tumor suppressors.",".",".",".",".","."]
["ENSRNOG00000067476",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","ENSRNOG00000067476","lncRNA","chr9:41232898-41234226:+",".",".",".",".","gi|56382171|gb|AC101277.16|",229,{"v":2e-114,"d":"2.00E-114"},"Mus musculus chromosome 1, clone RP23-101P2, complete sequence",".",".",".",".",".",".",".",".","pfam05766","NinG","Bacteriophage Lambda NinG protein. NinG or Rap is involved in recombination. Rap (recombination adept with plasmid) increases lambda-by-plasmid recombination catalysed by Escherichia coli's RecBCD pathway.",".",".",".",".","."]
["ENSRNOG00000070868",5,0.415133303,1,0.064330438,6.45313967,2.690001251,0.047753594,0.031246193,"up","yes","ENSRNOG00000070868","lncRNA","chr2:182221339-182233998:-",".",".",".",".","gi|33636843|gb|AC127252.3|",75,{"v":6e-29,"d":"6.00E-29"},"Mus musculus BAC clone RP24-276A6 from chromosome 3, complete sequence",".",".",".",".",".",".",".",".","pfam03344","Daxx","Daxx Family. The Daxx protein (also known as the Fas-binding protein) is thought to play a role in apoptosis, but precise role played by Daxx remains to be determined. Daxx forms a complex with Axin.",".",".",".",".","."]
["ENSRNOG00000005727",19,1.57750655,12,0.771965258,2.043494229,1.031038169,0.048648876,0.031773847,"up","yes","Galnt3","protein_coding","chr3:50742512-50766268:-","gi|75832150|ref|NP_001015032.2|",3433,0,"polypeptide N-acetylgalactosaminyltransferase 3 [Rattus norvegicus]","gi|672045842|ref|XM_006234290.2|",2747,0,"PREDICTED: Rattus norvegicus polypeptide N-acetylgalactosaminyltransferase 3 (Galnt3), transcript variant X1, mRNA","P70419",1305,0,"Polypeptide N-acetylgalactosaminyltransferase 3","Rv0696",59.7,2E-8,"COG0463","pfam00535","Glycos_transf_2","Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.","GO:0006493|protein O-linked glycosylation;GO:0007283|spermatogenesis;GO:0008150|biological_process;GO:0018242|protein O-linked glycosylation via serine;GO:0018243|protein O-linked glycosylation via threonine;","GO:0000139|Golgi membrane;GO:0005575|cellular_component;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;GO:0048471|perinuclear region of cytoplasm;","GO:0003674|molecular_function;GO:0004653|polypeptide N-acetylgalactosaminyltransferase activity;GO:0005509|calcium ion binding;GO:0030145|manganese ion binding;GO:0030246|carbohydrate binding;","K00710","GALNT; polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41]"]
["ENSRNOG00000023858",19,1.57750655,12,0.771965258,2.043494229,1.031038169,0.048648876,0.031773847,"up","yes","Prss39","protein_coding","chr9:36707328-36713001:+","gi|61557348|ref|NP_001013244.1|",1784,0,"serine protease 40 precursor [Rattus norvegicus]","gi|61557347|ref|NM_001013226.1|",1565,0,"Rattus norvegicus protease, serine, 39 (Prss39), mRNA","Q6AXZ6",691,0,"Serine protease 40","mlr3307",88.6,{"v":2e-18,"d":"2.00E-18"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;","GO:0001669|acrosomal vesicle;","GO:0004252|serine-type endopeptidase activity;",".","."]
["ENSRNOG00000026845",19,1.57750655,12,0.771965258,2.043494229,1.031038169,0.048648876,0.031773847,"up","yes","Fam81b","protein_coding","chr2:5771240-5879440:-","gi|568984107|ref|XP_006517568.1|",1940,0,"PREDICTED: protein FAM81B isoform X2 [Mus musculus]","gi|672015174|ref|XM_008775007.1|",1236,0,"PREDICTED: Rattus norvegicus family with sequence similarity 81, member B (Fam81b), mRNA","Q96LP2",676,0,"Protein FAM81B",".",".",".",".","pfam05667","DUF812","Protein of unknown function (DUF812). This family consists of several eukaryotic proteins of unknown function.",".",".",".",".","."]
["ENSRNOG00000030246",19,1.57750655,12,0.771965258,2.043494229,1.031038169,0.048648876,0.031773847,"up","yes","Btla","protein_coding","chr11:55564899-55587181:-","gi|47155571|ref|NP_998795.1|",1288,{"v":5e-158,"d":"5.00E-158"},"B- and T-lymphocyte attenuator precursor [Rattus norvegicus]","gi|672071184|ref|XM_006248341.2|",1828,0,"PREDICTED: Rattus norvegicus B and T lymphocyte associated (Btla), transcript variant X1, mRNA","Q6PNM1",500,{"v":2E-159,"d":"2.00E-159"},"B- and T-lymphocyte attenuator",".",".",".",".",".",".",".","GO:0002250|adaptive immune response;GO:0002768|immune response-regulating cell surface receptor signaling pathway;GO:0007166|cell surface receptor signaling pathway;GO:0030889|negative regulation of B cell proliferation;GO:0042130|negative regulation of T cell proliferation;GO:0046642|negative regulation of alpha-beta T cell proliferation;","GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;","GO:0038023|signaling receptor activity;","K06707","BTLA, CD272; B- and T-lymphocyte attenuator"]
["ENSRNOG00000038445",19,1.57750655,12,0.771965258,2.043494229,1.031038169,0.048648876,0.031773847,"up","yes","Rnf225","protein_coding","chr1:73543598-73546269:+","gi|157818895|ref|NP_001102804.1|",1032,{"v":1e-130,"d":"1.00E-130"},"ring finger protein 225 [Rattus norvegicus]","gi|157818894|ref|NM_001109334.1|",2275,0,"Rattus norvegicus ring finger protein 225 (Rnf225), mRNA","Q9D7D1",343,{"v":2E-109,"d":"2.00E-109"},"RING finger protein 225",".",".",".",".","pfam13639","zf-RING_2","Ring finger domain.",".","GO:0016021|integral component of membrane;","GO:0046872|metal ion binding;",".","."]
["ENSRNOG00000047393",19,1.57750655,12,0.771965258,2.043494229,1.031038169,0.048648876,0.031773847,"up","yes","Krt18","protein_coding","chr7:133157475-133161166:+","gi|68534953|ref|NP_446428.1|",1737,0,"keratin, type I cytoskeletal 18 [Rattus norvegicus]","gi|68534952|ref|NM_053976.1|",1369,0,"Rattus norvegicus keratin 18, type I (Krt18), mRNA","Q5BJY9",673,0,"Keratin, type I cytoskeletal 18",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0009750|response to fructose;GO:0031667|response to nutrient levels;GO:0033209|tumor necrosis factor-mediated signaling pathway;GO:0043000|Golgi to plasma membrane CFTR protein transport;GO:0043066|negative regulation of apoptotic process;GO:0045104|intermediate filament cytoskeleton organization;GO:0070365|hepatocyte differentiation;GO:0072497|mesenchymal stem cell differentiation;GO:0097191|extrinsic apoptotic signaling pathway;GO:0097284|hepatocyte apoptotic process;GO:1902488|cholangiocyte apoptotic process;","GO:0005615|extracellular space;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005815|microtubule organizing center;GO:0005829|cytosol;GO:0005882|intermediate filament;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016363|nuclear matrix;GO:0032991|protein-containing complex;GO:0034451|centriolar satellite;GO:0045095|keratin filament;GO:0071944|cell periphery;","GO:0003674|molecular_function;GO:0005198|structural molecule activity;GO:0097110|scaffold protein binding;","K07604","KRT1; type I keratin, acidic"]
["ENSRNOG00000001796",12,0.996319926,6,0.385982629,2.581255868,1.368073156,0.049859292,0.032412108,"up","yes","Dgkg","protein_coding","chr11:78384458-78577212:+","gi|6978761|ref|NP_037258.1|",4127,0,"diacylglycerol kinase gamma [Rattus norvegicus]","gi|298898019|emb|FQ231209.1|",3462,0,"Rattus norvegicus TL0AEA78YG22 mRNA sequence","P49620",1594,0,"Diacylglycerol kinase gamma","SPAC18B11.04",50.4,4e-06,"COG5126","pfam00609","DAGK_acc","Diacylglycerol kinase accessory domain. Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. This domain is assumed to be an accessory domain: its function is unknown.","GO:0006654|phosphatidic acid biosynthetic process;GO:0007205|protein kinase C-activating G protein-coupled receptor signaling pathway;GO:0035556|intracellular signal transduction;GO:0046339|diacylglycerol metabolic process;GO:0046486|glycerolipid metabolic process;GO:0046834|lipid phosphorylation;GO:0048666|neuron development;GO:0050773|regulation of dendrite development;GO:0090038|negative regulation of protein kinase C signaling;","GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0016020|membrane;","GO:0003951|NAD+ kinase activity;GO:0004143|diacylglycerol kinase activity;GO:0005509|calcium ion binding;GO:0005524|ATP binding;GO:0008289|lipid binding;","K00901","dgkA, DGK; diacylglycerol kinase (ATP) [EC:2.7.1.107]"]
["ENSRNOG00000004964",12,0.996319926,6,0.385982629,2.581255868,1.368073156,0.049859292,0.032412108,"up","yes","Erbb3","protein_coding","chr7:996225-1015525:-","gi|149029663|gb|EDL84834.1|",6383,0,"v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian), isoform CRA_a [Rattus norvegicus]","gi|451958072|ref|NM_017218.3|",4199,0,"Rattus norvegicus erb-b2 receptor tyrosine kinase 3 (Erbb3), mRNA","Q62799",2458,0,"Receptor tyrosine-protein kinase erbB-3",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0003197|endocardial cushion development;GO:0007162|negative regulation of cell adhesion;GO:0007165|signal transduction;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007173|epidermal growth factor receptor signaling pathway;GO:0007275|multicellular organism development;GO:0007399|nervous system development;GO:0007409|axonogenesis;GO:0007422|peripheral nervous system development;GO:0007519|skeletal muscle tissue development;GO:0007623|circadian rhythm;GO:0008284|positive regulation of cell proliferation;GO:0009410|response to xenobiotic stimulus;GO:0009611|response to wounding;GO:0009968|negative regulation of signal transduction;GO:0010628|positive regulation of gene expression;GO:0014037|Schwann cell differentiation;GO:0014065|phosphatidylinositol 3-kinase signaling;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0021545|cranial nerve development;GO:0032869|cellular response to insulin stimulus;GO:0033674|positive regulation of kinase activity;GO:0042127|regulation of cell proliferation;GO:0042476|odontogenesis;GO:0043524|negative regulation of neuron apoptotic process;GO:0043586|tongue development;GO:0046326|positive regulation of glucose import;GO:0051048|negative regulation of secretion;GO:0051402|neuron apoptotic process;GO:0055025|positive regulation of cardiac muscle tissue development;GO:0060056|mammary gland involution;GO:0061098|positive regulation of protein tyrosine kinase activity;GO:0070886|positive regulation of calcineurin-NFAT signaling cascade;GO:0097192|extrinsic apoptotic signaling pathway in absence of ligand;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005887|integral component of plasma membrane;GO:0009925|basal plasma membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0016328|lateral plasma membrane;GO:0038143|ERBB3:ERBB2 complex;GO:0043235|receptor complex;GO:0045177|apical part of cell;GO:0045211|postsynaptic membrane;","GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0005524|ATP binding;GO:0019838|growth factor binding;GO:0030296|protein tyrosine kinase activator activity;GO:0031625|ubiquitin protein ligase binding;GO:0038131|neuregulin receptor activity;GO:0038132|neuregulin binding;GO:0042802|identical protein binding;GO:0043125|ErbB-3 class receptor binding;GO:0046982|protein heterodimerization activity;","K05084","ERBB3, HER3; receptor tyrosine-protein kinase erbB-3 [EC:2.7.10.1]"]
["ENSRNOG00000014578",12,0.996319926,6,0.385982629,2.581255868,1.368073156,0.049859292,0.032412108,"up","yes","Fxyd4","protein_coding","chr4:151109779-151113637:-","gi|11693156|ref|NP_071783.1|",450,{"v":3E-51,"d":"3.00E-51"},"FXYD domain-containing ion transport regulator 4 precursor [Rattus norvegicus]","gi|11693155|ref|NM_022388.1|",1359,0,"Rattus norvegicus FXYD domain-containing ion transport regulator 4 (Fxyd4), mRNA","Q63113",177,{"v":1E-52,"d":"1.00E-52"},"FXYD domain-containing ion transport regulator 4",".",".",".",".","pfam02038","ATP1G1_PLM_MAT8","ATP1G1/PLM/MAT8 family.","GO:0071805|potassium ion transmembrane transport;GO:0098662|inorganic cation transmembrane transport;GO:2000649|regulation of sodium ion transmembrane transporter activity;","GO:0005890|sodium:potassium-exchanging ATPase complex;","GO:0005267|potassium channel activity;GO:0005515|protein binding;GO:0017080|sodium channel regulator activity;GO:0051117|ATPase binding;","K13359","FXYD4, CHIF; FXYD domain containing ion transport regulator 4"]
["ENSRNOG00000017061",12,0.996319926,6,0.385982629,2.581255868,1.368073156,0.049859292,0.032412108,"up","yes","Patl2","protein_coding","chr3:109075290-109083253:-","gi|149023122|gb|EDL80016.1|",2214,0,"rCG26544 [Rattus norvegicus]","gi|672017261|ref|XR_600317.1|",1523,0,"PREDICTED: Rattus norvegicus protein associated with topoisomerase II homolog 2 (yeast) (Patl2), misc_RNA","A2ARM1",748,0,"Protein PAT1 homolog 2",".",".",".",".","pfam09770","PAT1","Topoisomerase II-associated protein PAT1. Members of this family are necessary for accurate chromosome transmission during cell division.","GO:0000290|deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0010607|negative regulation of cytoplasmic mRNA processing body assembly;GO:0033962|cytoplasmic mRNA processing body assembly;","GO:0000932|P-body;GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0003723|RNA binding;",".","."]
["ENSRNOG00000033368",12,0.996319926,6,0.385982629,2.581255868,1.368073156,0.049859292,0.032412108,"up","yes","Dand5","protein_coding","chr19:23334164-23339589:+","gi|109507929|ref|XP_001064979.1|",767,{"v":5e-101,"d":"5.00E-101"},"PREDICTED: DAN domain family member 5 isoform X3 [Rattus norvegicus]","gi|672084599|ref|XM_001064979.3|",555,0,"PREDICTED: Rattus norvegicus DAN domain family, member 5 (Dand5), transcript variant X3, mRNA","Q76LW6",253,{"v":4e-84,"d":"4.00E-84"},"DAN domain family member 5",".",".",".",".","pfam03045","DAN","DAN domain. This domain contains 9 conserved cysteines and is extracellular. Therefore the cysteines may form disulphide bridges. This family of proteins has been termed the DAN family after the first member to be reported. This family includes DAN, Cerberus and Gremlin. The gremlin protein is an antagonist of bone morphogenetic protein signaling. It is postulated that all members of this family antagonise different TGF beta pfam00019 ligands. Recent work shows that the DAN protein is not an efficient antagonist of BMP-2/4 class signals, we found that DAN was able to interact with GDF-5 in a frog embryo assay, suggesting that DAN may regulate signaling by the GDF-5/6/7 class of BMPs in vivo.","GO:0003140|determination of left/right asymmetry in lateral mesoderm;GO:0003281|ventricular septum development;GO:0003283|atrial septum development;GO:0007368|determination of left/right symmetry;GO:0017015|regulation of transforming growth factor beta receptor signaling pathway;GO:0023019|signal transduction involved in regulation of gene expression;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030514|negative regulation of BMP signaling pathway;GO:0035582|sequestering of BMP in extracellular matrix;GO:0038101|sequestering of nodal from receptor via nodal binding;GO:0061371|determination of heart left/right asymmetry;GO:1900108|negative regulation of nodal signaling pathway;GO:1900176|negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry;","GO:0005615|extracellular space;","GO:0016015|morphogen activity;","K25479","DAND5, CERL2; DAN domain family member 5"]
["ENSRNOG00000049689",12,0.996319926,6,0.385982629,2.581255868,1.368073156,0.049859292,0.032412108,"up","yes","Smim18","protein_coding","chr16:58431742-58439651:+","gi|829862817|ref|XP_012639591.1|",537,{"v":1e-63,"d":"1.00E-63"},"PREDICTED: small integral membrane protein 18 isoform X1 [Microcebus murinus]","gi|672029453|ref|XM_006222253.2|",597,0,"PREDICTED: Rattus norvegicus uncharacterized LOC100909793 (LOC100909793), transcript variant X2, mRNA","P0DKX4",195,{"v":7e-60,"d":"7.00E-60"},"Small integral membrane protein 18",".",".",".",".","pfam13042","DUF3902","Protein of unknown function (DUF3902). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 170 amino acids in length. There is a conserved LGI sequence motif.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000067248",12,0.996319926,6,0.385982629,2.581255868,1.368073156,0.049859292,0.032412108,"up","yes","ENSRNOG00000067248","protein_coding","chr9:77055483-77060879:+","gi|852749799|ref|XP_012872059.1|",1421,{"v":9e-174,"d":"9.00E-174"},"PREDICTED: endogenous retrovirus group K member 8 Pol protein-like [Dipodomys ordii]","gi|49170117|gb|AC112361.5|",4345,0,"Rattus norvegicus 9 BAC CH230-61F12 (Children's Hospital Oakland Research Institute) complete sequence","P04026",486,{"v":4e-149,"d":"4.00E-149"},"Intracisternal A-particle Pol-related polyprotein (Fragment)",".",".",".",".","pfam00665","rve","Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyses the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.",".",".",".",".","."]
["ENSRNOG00000068034",12,0.996319926,6,0.385982629,2.581255868,1.368073156,0.049859292,0.032412108,"up","yes","ENSRNOG00000068034","protein_coding","chr17:42760219-42793359:-","gi|157822485|ref|NP_001101884.1|",558,{"v":7e-69,"d":"7.00E-69"},"histone cluster 1, H2bd [Rattus norvegicus]","gi|157822484|ref|NM_001108414.1|",377,0,"Rattus norvegicus histone cluster 1, H2bd (Hist1h2bd), mRNA","P10854",218,{"v":9e-70,"d":"9.00E-70"},"Histone H2B type 1-M",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.",".",".",".",".","."]

{"sheet":"3D_CTX_down","index":4,"n_rows":1510,"n_cols":38,"rows_kept":1510}
["Gene","3D_count","3D_normalize","CTX_count","CTX_normalize","FoldChange","Log2FoldChange","pval","padj","Up/Down","Significant","GeneName","Biotype","Position","NR:Seq-id","NR:Score","NR:Evalue","NR:Description","NT:Seq-id","NT:Score","NT:Evalue","NT:Description","Uniprot:UniProtKB-AC","Uniprot:Score","Uniprot:Evalue","Uniprot:Description","COG:gene","COG:Score","COG:Eval","COG:num","Pfam:pfam_ID","Pfam:pfam_Name","Pfam:pfam_Description","GO:biological_process","GO:cellular_component","GO:molecular_function","KEGG:KO","KEGG:Description"]
["ENSRNOG00000029886",8172,687.5534154,48066,3092.106842,0.222357587,-2.169046465,0,0,"down","yes","Hba-a2","protein_coding","chr10:15307815-15338392:-","gi|392331680|ref|XP_002724712.2|",1102,{"v":3E-148,"d":"3.00E-148"},"PREDICTED: hemoglobin subunit theta-1-like isoform X1 [Rattus norvegicus]","gi|672067068|ref|XM_002727758.4|",1089,0,"PREDICTED: Rattus norvegicus hemoglobin, theta 1B (Hbq1b), transcript variant X1, mRNA","P09105",201,{"v":1E-61,"d":"1.00E-61"},"Hemoglobin subunit theta-1",".",".",".",".","pfam00042","Globin","Globin.","GO:0001701|in utero embryonic development;GO:0009617|response to bacterium;GO:0015671|oxygen transport;GO:0035634|response to stilbenoid;GO:0042744|hydrogen peroxide catabolic process;GO:0045776|negative regulation of blood pressure;GO:0048821|erythrocyte development;GO:0051930|regulation of sensory perception of pain;GO:0098869|cellular oxidant detoxification;","GO:0005833|hemoglobin complex;GO:0031838|haptoglobin-hemoglobin complex;GO:0045202|synapse;","GO:0001540|amyloid-beta binding;GO:0004601|peroxidase activity;GO:0005344|oxygen carrier activity;GO:0005506|iron ion binding;GO:0005515|protein binding;GO:0019825|oxygen binding;GO:0020037|heme binding;GO:0031720|haptoglobin binding;GO:0043177|organic acid binding;","K13822","HBA; hemoglobin subunit alpha"]
["ENSRNOG00000071185",5225,439.6067787,26213,1686.293776,0.260694065,-1.939570358,0,0,"down","yes","ENSRNOG00000071185","lncRNA","chr4:78274962-78293658:+","gi|667282457|ref|XP_008574777.1|",340,{"v":6e-61,"d":"6.00E-61"},"PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103593548 [Galeopterus variegatus]","gi|241982901|gb|AC136178.3|",2627,0,"Rattus norvegicus CH230-435P16 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P03359",99,{"v":1E-53,"d":"1.00E-53"},"Gag-Pol polyprotein",".",".",".",".","pfam02093","Gag_p30","Gag P30 core shell protein. According to Swiss-Prot annotation this protein is the viral core shell protein. P30 is essential for viral assembly.",".",".",".",".","."]
["ENSRNOG00000020097",5729,482.0109541,26638,1713.634212,0.281279955,-1.82992135,0,0,"down","yes","Inha","protein_coding","chr9:76993589-76997248:+","gi|6981102|ref|NP_036722.1|",1521,0,"inhibin alpha chain precursor [Rattus norvegicus]","gi|126506324|ref|NM_012590.2|",1281,0,"Rattus norvegicus inhibin alpha (Inha), mRNA","P17490",590,0,"Inhibin alpha chain",".",".",".",".","pfam00019","TGF_beta","Transforming growth factor beta like domain.","GO:0001541|ovarian follicle development;GO:0008584|male gonad development;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0042127|regulation of cell proliferation;GO:0042541|hemoglobin biosynthetic process;GO:0046882|negative regulation of follicle-stimulating hormone secretion;GO:0051726|regulation of cell cycle;GO:0060395|SMAD protein signal transduction;","GO:0001750|photoreceptor outer segment;GO:0001917|photoreceptor inner segment;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0034673|inhibin-betaglycan-ActRII complex;GO:0043025|neuronal cell body;GO:0043512|inhibin A complex;GO:0043513|inhibin B complex;","GO:0005102|signaling receptor binding;GO:0005125|cytokine activity;GO:0005179|hormone activity;GO:0008083|growth factor activity;GO:0034711|inhibin binding;GO:0044877|protein-containing complex binding;","K05500","INHA; inhibin, alpha"]
["ENSRNOG00000053086",12195,1026.029601,40215,2587.048572,0.396602372,-1.334234787,0,0,"down","yes","Selenop","protein_coding","chr2:52498339-52508852:+","gi|15011857|ref|NP_062065.2|",1601,0,"selenoprotein P precursor [Rattus norvegicus]","gi|206893|gb|M63574.1|RATSELENOP",2372,0,"Rat selenoprotein P mRNA, complete cds","P25236",621,0,"Selenoprotein P",".",".",".",".","pfam04592","SelP_N","Selenoprotein P, N terminal region. SelP is the only known eukaryotic selenoprotein that contains multiple selenocysteine (Sec) residues, and accounts for more than 50% of the selenium content of rat and human plasma. It is thought to be glycosylated. SelP may have antioxidant properties. It can attach to epithelial cells, and may protect vascular endothelial cells against peroxynitrite toxicity. The high selenium content of SelP suggests that it may be involved in selenium intercellular transport or storage. The promoter structure of bovine SelP suggest that it may be involved in countering heavy metal intoxication, and may also have a developmental function. The N-terminal region of SelP can exist independently of the C terminal region. Zebrafish selenoprotein Pb lacks the C terminal Sec-rich region, and a protein encoded by the rat SelP gene and lacking this region has also been reported. N-terminal region contains a conserved SecxxCys motif, which is similar to the CysxxCys found in thioredoxins. It is speculated that the N terminal region may adopt a thioredoxin fold and catalyse redox reactions. The N-terminal region also contains a His-rich region, which is thought to mediate heparin binding. Binding to heparan proteoglycans could account for the membrane binding properties of SelP. The function of the bacterial members of this family is uncharcterised.","GO:0001887|selenium compound metabolic process;GO:0007420|brain development;GO:0007626|locomotory behavior;GO:0009791|post-embryonic development;GO:0010269|response to selenium ion;GO:0019953|sexual reproduction;GO:0040008|regulation of growth;","GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0008430|selenium binding;",".","."]
["ENSRNOG00000019741",1827,153.7151358,13311,856.3024627,0.179510328,-2.477861245,0,0,"down","yes","Isyna1","protein_coding","chr16:18839145-18841979:-","gi|189163481|ref|NP_001013902.2|",2882,0,"inositol-3-phosphate synthase 1 [Rattus norvegicus]","gi|189163480|ref|NM_001013880.2|",1863,0,"Rattus norvegicus inositol-3-phosphate synthase 1 (Isyna1), mRNA","Q6AYK3",1114,0,"Inositol-3-phosphate synthase 1","YJL153c",525,{"v":4e-179,"d":"4.00E-179"},"COG1260","pfam07994","NAD_binding_5","Myo-inositol-1-phosphate synthase. This is a family of myo-inositol-1-phosphate synthases. Inositol-1-phosphate catalyses the conversion of glucose-6- phosphate to inositol-1-phosphate, which is then dephosphorylated to inositol. Inositol phosphates play an important role in signal transduction.","GO:0006021|inositol biosynthetic process;GO:0008654|phospholipid biosynthetic process;","GO:0005737|cytoplasm;","GO:0004512|inositol-3-phosphate synthase activity;","K01858","INO1, ISYNA1; myo-inositol-1-phosphate synthase [EC:5.5.1.4]"]
["ENSRNOG00000069830",2574,216.5641815,14560,936.65118,0.231211134,-2.112717222,0,0,"down","yes","ENSRNOG00000069830","protein_coding","chr3:74282149-74287593:-","gi|852749799|ref|XP_012872059.1|",1849,0,"PREDICTED: endogenous retrovirus group K member 8 Pol protein-like [Dipodomys ordii]","gi|46240867|gb|AC107531.8|",5002,0,"Rattus norvegicus 1 BAC CH230-158N3 (Children's Hospital Oakland Research Institute) complete sequence","P04026",563,0,"Intracisternal A-particle Pol-related polyprotein (Fragment)","YIL082w-a_2",80.5,{"v":4E-14,"d":"4.00E-14"},"COG2801","pfam00078","RVT_1","Reverse transcriptase (RNA-dependent DNA polymerase). A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs, hepadnaviruses, and caulimoviruses.",".",".",".",".","."]
["ENSRNOG00000021201",6986,587.7689868,23816,1532.093716,0.383637751,-1.382183404,0,0,"down","yes","Txnip","protein_coding","chr2:184092991-184096886:+","gi|56912221|ref|NP_001008767.1|",1869,0,"thioredoxin-interacting protein [Rattus norvegicus]","gi|1216375|gb|U30789.1|RNU30789",1743,0,"Rattus norvegicus clone N27 mRNA","Q5M7W1",724,0,"Thioredoxin-interacting protein",".",".",".",".","pfam00339","Arrestin_N","Arrestin (or S-antigen), N-terminal domain. Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006606|protein import into nucleus;GO:0006979|response to oxidative stress;GO:0009410|response to xenobiotic stimulus;GO:0009612|response to mechanical stimulus;GO:0009749|response to glucose;GO:0015031|protein transport;GO:0030216|keratinocyte differentiation;GO:0032355|response to estradiol;GO:0032570|response to progesterone;GO:0042127|regulation of cell proliferation;GO:0042542|response to hydrogen peroxide;GO:0043065|positive regulation of apoptotic process;GO:0043086|negative regulation of catalytic activity;GO:0048008|platelet-derived growth factor receptor signaling pathway;GO:0051592|response to calcium ion;GO:0051782|negative regulation of cell division;GO:0071228|cellular response to tumor cell;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005758|mitochondrial intermembrane space;","GO:0003674|molecular_function;GO:0004857|enzyme inhibitor activity;GO:0031625|ubiquitin protein ligase binding;","K20910","TXNIP; thioredoxin-interacting protein"]
["ENSRNOG00000005387",2429,204.3645675,11445,736.261865,0.277570491,-1.849073893,0,0,"down","yes","ENSRNOG00000005387","protein_coding","chrX:14348910-14353580:+","gi|148702008|gb|EDL33955.1|",492,{"v":8e-54,"d":"8.00E-54"},"mCG116386, isoform CRA_e, partial [Mus musculus]","gi|564398624|ref|XM_006256694.1|",686,0,"PREDICTED: Rattus norvegicus RNA binding motif (RNP1, RRM) protein 3 (Rbm3), transcript variant X1, mRNA","O89086",177,{"v":9e-50,"d":"9.00E-50"},"RNA-binding protein 3","TP0356",72.4,{"v":8E-14,"d":"8.00E-14"},"COG0724","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0006412|translation;GO:0006417|regulation of translation;GO:0009409|response to cold;GO:0035196|production of miRNAs involved in gene silencing by miRNA;GO:0045727|positive regulation of translation;GO:0048026|positive regulation of mRNA splicing, via spliceosome;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005681|spliceosomal complex;GO:0005737|cytoplasm;GO:0030425|dendrite;","GO:0003723|RNA binding;GO:0005515|protein binding;GO:0043023|ribosomal large subunit binding;","K13186","RBM3; RNA-binding protein 3"]
["ENSRNOG00000018630",9953,837.3983288,26797,1723.862752,0.485768561,-1.041658973,0,0,"down","yes","Gapdh","protein_coding","chr4:157962343-157966235:-","gi|8393418|ref|NP_058704.1|",1734,0,"glyceraldehyde-3-phosphate dehydrogenase [Rattus norvegicus]","gi|402691727|ref|NM_017008.4|",1179,0,"Rattus norvegicus glyceraldehyde-3-phosphate dehydrogenase (Gapdh), mRNA","P04797",672,0,"Glyceraldehyde-3-phosphate dehydrogenase","SPBC354.12",499,{"v":8E-167,"d":"8.00E-167"},"COG0057","pfam02800","Gp_dh_C","Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain. GAPDH is a tetrameric NAD-binding enzyme involved in glycolysis and glyconeogenesis. C-terminal domain is a mixed alpha/antiparallel beta fold.","GO:0000226|microtubule cytoskeleton organization;GO:0001819|positive regulation of cytokine production;GO:0005975|carbohydrate metabolic process;GO:0006094|gluconeogenesis;GO:0006096|glycolytic process;GO:0006915|apoptotic process;GO:0007565|female pregnancy;GO:0010951|negative regulation of endopeptidase activity;GO:0017148|negative regulation of translation;GO:0019933|cAMP-mediated signaling;GO:0031640|killing of cells of other organism;GO:0032481|positive regulation of type I interferon production;GO:0035606|peptidyl-cysteine S-trans-nitrosylation;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0050821|protein stabilization;GO:0050832|defense response to fungus;GO:0051402|neuron apoptotic process;GO:0051873|killing by host of symbiont cells;GO:0060359|response to ammonium ion;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0071346|cellular response to interferon-gamma;GO:1905460|negative regulation of vascular associated smooth muscle cell apoptotic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005811|lipid droplet;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0015630|microtubule cytoskeleton;GO:0031965|nuclear membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0097452|GAIT complex;GO:0098978|glutamatergic synapse;GO:0099092|postsynaptic density, intracellular component;GO:1990904|ribonucleoprotein complex;","GO:0004365|glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity;GO:0005515|protein binding;GO:0008017|microtubule binding;GO:0019828|aspartic-type endopeptidase inhibitor activity;GO:0019899|enzyme binding;GO:0035605|peptidyl-cysteine S-nitrosylase activity;GO:0042802|identical protein binding;GO:0050661|NADP binding;GO:0051287|NAD binding;GO:0097718|disordered domain specific binding;","K00134","GAPDH, gapA; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]"]
["ENSRNOG00000060237",1927,162.1286627,9787,629.6019985,0.257509765,-1.957300953,0,0,"down","yes","Inhbb","protein_coding","chr13:30530860-30537832:-","gi|29179420|gb|AAH48845.1|",1775,0,"Inhbb protein, partial [Mus musculus]","gi|145966740|ref|NM_008381.3|",3455,0,"Mus musculus inhibin beta-B (Inhbb), mRNA","P17491",688,0,"Inhibin beta B chain",".",".",".",".","pfam00019","TGF_beta","Transforming growth factor beta like domain.","GO:0007283|spermatogenesis;GO:0008584|male gonad development;GO:0008585|female gonad development;GO:0009267|cellular response to starvation;GO:0009611|response to wounding;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0014070|response to organic cyclic compound;GO:0017085|response to insecticide;GO:0021983|pituitary gland development;GO:0032686|negative regulation of hepatocyte growth factor production;GO:0032869|cellular response to insulin stimulus;GO:0032924|activin receptor signaling pathway;GO:0034698|response to gonadotropin;GO:0044320|cellular response to leptin stimulus;GO:0045444|fat cell differentiation;GO:0046676|negative regulation of insulin secretion;GO:0046881|positive regulation of follicle-stimulating hormone secretion;GO:0046882|negative regulation of follicle-stimulating hormone secretion;GO:0048599|oocyte development;GO:0060279|positive regulation of ovulation;GO:0060395|SMAD protein signal transduction;GO:0071277|cellular response to calcium ion;GO:0071320|cellular response to cAMP;GO:0071347|cellular response to interleukin-1;GO:0071397|cellular response to cholesterol;GO:0071407|cellular response to organic cyclic compound;GO:0072520|seminiferous tubule development;GO:0097067|cellular response to thyroid hormone stimulus;GO:1904017|cellular response to Thyroglobulin triiodothyronine;GO:1990636|reproductive senescence;GO:2001235|positive regulation of apoptotic signaling pathway;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0043513|inhibin B complex;GO:0048471|perinuclear region of cytoplasm;GO:0071944|cell periphery;","GO:0005125|cytokine activity;GO:0005179|hormone activity;GO:0008083|growth factor activity;GO:0034711|inhibin binding;GO:0042803|protein homodimerization activity;GO:0044877|protein-containing complex binding;","K22687","INHBB; inhibin beta B chain"]
["ENSRNOG00000056596",4620,388.7049411,14424,927.9022404,0.418907213,-1.25529737,0,0,"down","yes","Alas1","protein_coding","chr8:106876514-106889917:-","gi|42475958|ref|NP_077810.2|",2935,0,"5-aminolevulinate synthase, nonspecific, mitochondrial precursor [Rattus norvegicus]","gi|42475957|ref|NM_024484.2|",1834,0,"Rattus norvegicus 5'-aminolevulinate synthase 1 (Alas1), mRNA","P13195",1135,0,"5-aminolevulinate synthase, nonspecific, mitochondrial","AGc4738",389,{"v":3E-122,"d":"3.00E-122"},"COG0156","pfam00155","Aminotran_1_2","Aminotransferase class I and II.","GO:0001666|response to hypoxia;GO:0006782|protoporphyrinogen IX biosynthetic process;GO:0006783|heme biosynthetic process;GO:0009410|response to xenobiotic stimulus;GO:0009635|response to herbicide;GO:0010033|response to organic substance;GO:0010045|response to nickel cation;GO:0014070|response to organic cyclic compound;GO:0031667|response to nutrient levels;GO:0032025|response to cobalt ion;GO:0032869|cellular response to insulin stimulus;GO:0034698|response to gonadotropin;GO:0042541|hemoglobin biosynthetic process;GO:0045471|response to ethanol;GO:0048821|erythrocyte development;GO:0051591|response to cAMP;GO:0070541|response to platinum ion;GO:0071407|cellular response to organic cyclic compound;","GO:0005654|nucleoplasm;GO:0005739|mitochondrion;GO:0005759|mitochondrial matrix;GO:0005829|cytosol;","GO:0003870|5-aminolevulinate synthase activity;GO:0030170|pyridoxal phosphate binding;GO:0042802|identical protein binding;","K00643","E2.3.1.37, ALAS; 5-aminolevulinate synthase [EC:2.3.1.37]"]
["ENSRNOG00000010306",2639,222.032974,9963,640.9241556,0.346426285,-1.529379698,0,0,"down","yes","H2az1","protein_coding","chr2:226355708-226358485:+","gi|946732930|ref|XP_014398677.1|",544,{"v":9e-64,"d":"9.00E-64"},"PREDICTED: histone H2A.Z, partial [Myotis brandtii]","gi|298903825|emb|FQ213837.1|",791,0,"Rattus norvegicus TL0AAA45YF14 mRNA sequence","Q6YNC8",204,{"v":9e-62,"d":"9.00E-62"},"Histone H2A.Z","SPBC11B10.10c",155,{"v":2e-43,"d":"2.00E-43"},"COG5262","pfam00125","Histone","Core histone H2A/H2B/H3/H4.","GO:0032869|cellular response to insulin stimulus;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0071392|cellular response to estradiol stimulus;","GO:0000786|nucleosome;GO:0000791|euchromatin;GO:0000792|heterochromatin;GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000979|RNA polymerase II core promoter sequence-specific DNA binding;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0031490|chromatin DNA binding;GO:0031492|nucleosomal DNA binding;GO:0046982|protein heterodimerization activity;","K11251","H2A; histone H2A"]
["ENSRNOG00000047098",452,38.02914143,4055,260.8599268,0.145783762,-2.778098062,0,0,"down","yes","Hbb-b1","protein_coding","chr1:158120200-158252012:-","gi|40445397|ref|NP_942071.1|",744,{"v":1e-96,"d":"1.00E-96"},"hemoglobin, beta adult major chain [Rattus norvegicus]","gi|298901836|emb|FQ228130.1|",564,0,"Rattus norvegicus TL0AEA10YG08 mRNA sequence","P11517",284,{"v":2E-95,"d":"2.00E-95"},"Hemoglobin subunit beta-2",".",".",".",".","pfam00042","Globin","Globin.","GO:0015671|oxygen transport;GO:0098869|cellular oxidant detoxification;","GO:0005833|hemoglobin complex;","GO:0005344|oxygen carrier activity;GO:0019825|oxygen binding;GO:0020037|heme binding;GO:0046872|metal ion binding;","K13823","HBB; hemoglobin subunit beta"]
["ENSRNOG00000051624",6010,505.6529646,16035,1031.538576,0.490192976,-1.028578283,0,0,"down","yes","Hspe1","protein_coding","chr9:56589789-56593089:+","gi|674078133|ref|XP_008846520.1|",499,{"v":3e-59,"d":"3.00E-59"},"PREDICTED: 10 kDa heat shock protein, mitochondrial isoform X2 [Nannospalax galili]","gi|298894148|emb|FQ220992.1|",545,0,"Rattus norvegicus TL0ADA40YO12 mRNA sequence","P26772",180,{"v":4E-55,"d":"4.00E-55"},"10 kDa heat shock protein, mitochondrial","SPCC550.06c",75.1,{"v":3e-16,"d":"3.00E-16"},"COG0234","pfam00166","Cpn10","Chaperonin 10 Kd subunit. This family contains GroES and Gp31-like chaperonins. Gp31 is a functional co-chaperonin that is required for the folding and assembly of Gp23, a major capsid protein, during phage morphogenesis.","GO:0006457|protein folding;GO:0051085|chaperone cofactor-dependent protein refolding;","GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0005759|mitochondrial matrix;GO:0005782|peroxisomal matrix;","GO:0005524|ATP binding;GO:0046872|metal ion binding;GO:0051082|unfolded protein binding;GO:0051087|chaperone binding;","K04078","groES, HSPE1; chaperonin GroES"]
["ENSRNOG00000017895",4357,366.5773655,12373,795.9605117,0.460547176,-1.11857915,0,0,"down","yes","Eno1","protein_coding","chr5:160719951-160731336:+","gi|564354207|ref|XP_006239506.1|",2313,0,"PREDICTED: alpha-enolase isoform X1 [Rattus norvegicus]","gi|158186650|ref|NM_001109908.1|",1701,0,"Rattus norvegicus enolase 1, (alpha) (Eno1), transcript variant 2, mRNA","P04764",875,0,"Alpha-enolase","YGR254w",560,0,"COG0148","pfam00113","Enolase_C","Enolase, C-terminal TIM barrel domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001701|in utero embryonic development;GO:0006096|glycolytic process;GO:0009615|response to virus;GO:0010756|positive regulation of plasminogen activation;GO:0030308|negative regulation of cell growth;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045933|positive regulation of muscle contraction;GO:0051099|positive regulation of binding;GO:0061621|canonical glycolysis;GO:0070371|ERK1 and ERK2 cascade;GO:0071456|cellular response to hypoxia;GO:0098761|cellular response to interleukin-7;GO:1903298|negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway;GO:2001171|positive regulation of ATP biosynthetic process;","GO:0000015|phosphopyruvate hydratase complex;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0019897|extrinsic component of plasma membrane;GO:0030426|growth cone;GO:0043005|neuron projection;GO:0045121|membrane raft;GO:0097060|synaptic membrane;","GO:0000287|magnesium ion binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003723|RNA binding;GO:0004634|phosphopyruvate hydratase activity;GO:0005515|protein binding;GO:0019899|enzyme binding;GO:0031072|heat shock protein binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0044877|protein-containing complex binding;GO:0051020|GTPase binding;","K01689","ENO, eno; enolase [EC:4.2.1.11]"]
["ENSRNOG00000013009",3098,260.6510623,9871,635.0057553,0.410470394,-1.284649928,0,0,"down","yes","Ldha","protein_coding","chr1:97366021-97433472:+","gi|564328458|ref|XP_006229294.1|",1832,0,"PREDICTED: L-lactate dehydrogenase A chain isoform X1 [Rattus norvegicus]","gi|672036280|ref|XM_006229232.2|",1606,0,"PREDICTED: Rattus norvegicus lactate dehydrogenase A (Ldha), transcript variant X1, mRNA","P04642",648,0,"L-lactate dehydrogenase A chain","CAC0267",264,{"v":1e-80,"d":"1.00E-80"},"COG0039","pfam00056","Ldh_1_N","lactate/malate dehydrogenase, NAD binding domain. L-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate. The enzyme participates in the citric acid cycle. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes. N-terminus (this family) is a Rossmann NAD-binding fold. C-terminus is an unusual alpha+beta fold.","GO:0001666|response to hypoxia;GO:0006089|lactate metabolic process;GO:0007584|response to nutrient;GO:0009410|response to xenobiotic stimulus;GO:0009749|response to glucose;GO:0014070|response to organic cyclic compound;GO:0019661|glucose catabolic process to lactate via pyruvate;GO:0019674|NAD metabolic process;GO:0021762|substantia nigra development;GO:0031668|cellular response to extracellular stimulus;GO:0042542|response to hydrogen peroxide;GO:0043065|positive regulation of apoptotic process;GO:0043627|response to estrogen;GO:0048569|post-embryonic animal organ development;GO:0051591|response to cAMP;","GO:0005829|cytosol;GO:0035686|sperm fibrous sheath;","GO:0004457|lactate dehydrogenase activity;GO:0004459|L-lactate dehydrogenase activity;GO:0005515|protein binding;GO:0019900|kinase binding;GO:0042802|identical protein binding;GO:0051287|NAD binding;","K00016","LDH, ldh; L-lactate dehydrogenase [EC:1.1.1.27]"]
["ENSRNOG00000068973",234,19.68765286,2998,192.8626537,0.102081209,-3.292210774,0,0,"down","yes","ENSRNOG00000068973","protein_coding","chr1:15046564-15050125:-","gi|45478088|gb|AAS66215.1|",680,{"v":1e-77,"d":"1.00E-77"},"LRRG00124 [Rattus norvegicus]","gi|34555688|gb|AY343914.1|",520,0,"Rattus norvegicus genomic sequence","P11369",230,{"v":8e-69,"d":"8.00E-69"},"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam12488","DUF3704","Protein of unknown function (DUF3704). This domain family is found in eukaryotes, and is approximately 30 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000034198",2976,250.3865595,9577,616.0926065,0.40641059,-1.298990101,0,0,"down","yes","ENSRNOG00000034198","protein_coding","chrX:99228458-99247763:+","gi|188595723|ref|NP_001120974.1|",322,{"v":2e-32,"d":"2.00E-32"},"WW domain-binding protein 5 [Rattus norvegicus]","gi|298892064|emb|FQ220910.1|",992,0,"Rattus norvegicus TL0ADA41YD18 mRNA sequence","Q9DD24",118,{"v":2e-30,"d":"2.00E-30"},"Transcription elongation factor A protein-like 9",".",".",".",".","pfam04538","BEX","Brain expressed X-linked like family. This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.",".","GO:0005634|nucleus;","GO:0050699|WW domain binding;",".","."]
["ENSRNOG00000013279",1210,101.8036751,5601,360.3147843,0.282540932,-1.823468206,0,0,"down","yes","ENSRNOG00000013279","protein_coding","chr1:243078774-243114229:+","gi|672014957|ref|XP_008773072.1|",1789,0,"PREDICTED: acyl-CoA desaturase 1-like [Rattus norvegicus]","gi|672014956|ref|XM_008774850.1|",1268,0,"PREDICTED: Rattus norvegicus similar to stearoyl-coenzyme A desaturase 3 (LOC681458), mRNA","Q99PL7",661,0,"Acyl-CoA desaturase 3","SPCC1281.06c_1",205,{"v":4e-57,"d":"4.00E-57"},"COG1398","pfam00487","FA_desaturase","Fatty acid desaturase.","GO:0006636|unsaturated fatty acid biosynthetic process;GO:0070542|response to fatty acid;GO:1903966|monounsaturated fatty acid biosynthetic process;","GO:0005789|endoplasmic reticulum membrane;GO:0030176|integral component of endoplasmic reticulum membrane;","GO:0004768|stearoyl-CoA 9-desaturase activity;GO:0005506|iron ion binding;GO:0032896|palmitoyl-CoA 9-desaturase activity;","K00507","SCD, desC; stearoyl-CoA desaturase (Delta-9 desaturase) [EC:1.14.19.1]"]
["ENSRNOG00000009339",615,51.74319022,3945,253.7835786,0.20388707,-2.29415781,0,0,"down","yes","Cenpe","protein_coding","chr2:223636998-223695669:+","gi|672044374|ref|XP_006233412.2|",11903,0,"PREDICTED: centromere-associated protein E isoform X2 [Rattus norvegicus]","gi|672044373|ref|XM_006233350.2|",7599,0,"PREDICTED: Rattus norvegicus centromere protein E (Cenpe), transcript variant X2, mRNA","Q6RT24",3648,0,"Centromere-associated protein E","SPAC1834.07",222,{"v":7e-60,"d":"7.00E-60"},"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0000278|mitotic cell cycle;GO:0007018|microtubule-based movement;GO:0007052|mitotic spindle organization;GO:0007057|spindle assembly involved in female meiosis I;GO:0007059|chromosome segregation;GO:0007079|mitotic chromosome movement towards spindle pole;GO:0007080|mitotic metaphase plate congression;GO:0007088|regulation of mitotic nuclear division;GO:0007094|mitotic spindle assembly checkpoint;GO:0008608|attachment of spindle microtubules to kinetochore;GO:0030071|regulation of mitotic metaphase/anaphase transition;GO:0031647|regulation of protein stability;GO:0045184|establishment of protein localization;GO:0045842|positive regulation of mitotic metaphase/anaphase transition;GO:0045860|positive regulation of protein kinase activity;GO:0050793|regulation of developmental process;GO:0051310|metaphase plate congression;GO:0051315|attachment of mitotic spindle microtubules to kinetochore;GO:0051382|kinetochore assembly;GO:0051984|positive regulation of chromosome segregation;GO:0051987|positive regulation of attachment of spindle microtubules to kinetochore;GO:0099606|microtubule plus-end directed mitotic chromosome migration;GO:0099607|lateral attachment of mitotic spindle microtubules to kinetochore;","GO:0000775|chromosome, centromeric region;GO:0000776|kinetochore;GO:0000779|condensed chromosome, centromeric region;GO:0000940|condensed chromosome outer kinetochore;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005694|chromosome;GO:0005828|kinetochore microtubule;GO:0005829|cytosol;GO:0005874|microtubule;GO:0015630|microtubule cytoskeleton;GO:0030496|midbody;GO:0051233|spindle midzone;GO:1990023|mitotic spindle midzone;","GO:0003777|microtubule motor activity;GO:0005524|ATP binding;GO:0008017|microtubule binding;GO:0008574|ATP-dependent microtubule motor activity, plus-end-directed;GO:0019901|protein kinase binding;GO:0043515|kinetochore binding;","K11498","CENPE; centromeric protein E"]
["ENSRNOG00000002389",4239,356.6494038,11667,750.5432223,0.475188361,-1.073428594,0,0,"down","yes","Morf4l2","protein_coding","chrX:100082404-100093728:-","gi|56090315|ref|NP_001007715.1|",1534,0,"mortality factor 4-like protein 2 [Rattus norvegicus]","gi|28208137|emb|AL671887.18|",2048,0,"Mouse DNA sequence from clone RP23-197O15 on chromosome X, complete sequence","Q6QI89",595,0,"Mortality factor 4-like protein 2",".",".",".",".","pfam05712","MRG","MRG. This family consists of three different eukaryotic proteins (mortality factor 4 (MORF4/MRG15), male-specific lethal 3(MSL-3) and ESA1-associated factor 3(EAF3)). It is thought that the MRG family is involved in transcriptional regulation via histone acetylation. It contains 2 chromo domains and a leucine zipper motif.","GO:0006281|DNA repair;GO:0008150|biological_process;GO:0016573|histone acetylation;GO:0016575|histone deacetylation;GO:0040008|regulation of growth;GO:0043967|histone H4 acetylation;GO:0043968|histone H2A acetylation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051155|positive regulation of striated muscle cell differentiation;","GO:0000123|histone acetyltransferase complex;GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005886|plasma membrane;GO:0035267|NuA4 histone acetyltransferase complex;","GO:0003674|molecular_function;","K11342","MORF4L2, MRGX; mortality factor 4-like protein 2"]
["ENSRNOG00000019018",1823,153.3785947,6728,432.8151881,0.354374336,-1.496653969,0,0,"down","yes","Plat","protein_coding","chr16:69240585-69268223:-","gi|564389730|ref|XP_006253409.1|",2820,0,"PREDICTED: tissue-type plasminogen activator isoform X2 [Rattus norvegicus]","gi|672080489|ref|XM_006253347.2|",2441,0,"PREDICTED: Rattus norvegicus plasminogen activator, tissue (Plat), transcript variant X1, mRNA","P19637",1067,0,"Tissue-type plasminogen activator","mlr3307",109,{"v":8e-25,"d":"8.00E-25"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0001666|response to hypoxia;GO:0006508|proteolysis;GO:0014909|smooth muscle cell migration;GO:0031639|plasminogen activation;GO:0035249|synaptic transmission, glutamatergic;GO:0042060|wound healing;GO:0045861|negative regulation of proteolysis;GO:0048008|platelet-derived growth factor receptor signaling pathway;GO:0048167|regulation of synaptic plasticity;GO:0051591|response to cAMP;GO:0060279|positive regulation of ovulation;GO:0060468|prevention of polyspermy;GO:0070542|response to fatty acid;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0071373|cellular response to luteinizing hormone stimulus;GO:0071549|cellular response to dexamethasone stimulus;GO:0099183|trans-synaptic signaling by BDNF, modulating synaptic transmission;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0009986|cell surface;GO:0030141|secretory granule;GO:0045177|apical part of cell;GO:0045202|synapse;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098794|postsynapse;GO:0098978|glutamatergic synapse;GO:0098992|neuronal dense core vesicle;GO:0099544|perisynaptic space;","GO:0003674|molecular_function;GO:0004252|serine-type endopeptidase activity;GO:0005102|signaling receptor binding;GO:0051219|phosphoprotein binding;","K01343","PLAT; tissue plasminogen activator [EC:3.4.21.68]"]
["ENSRNOG00000067242",853,71.76738416,4457,286.720763,0.250304106,-1.99824614,0,0,"down","yes","ENSRNOG00000067242","protein_coding","chrX:111691855-111700281:-","gi|148676020|gb|EDL07967.1|",1103,{"v":4e-135,"d":"4.00E-135"},"mCG1029965 [Mus musculus]","gi|46240867|gb|AC107531.8|",2301,0,"Rattus norvegicus 1 BAC CH230-158N3 (Children's Hospital Oakland Research Institute) complete sequence","P31789",206,{"v":3e-55,"d":"3.00E-55"},"Envelope glycoprotein",".",".",".",".","pfam00517","GP41","Retroviral envelope protein. This family includes envelope protein from a variety of retroviruses. It includes the GP41 subunit of the envelope protein complex from human and simian immunodeficiency viruses (HIV and SIV) which mediate membrane fusion during viral entry. The family also includes bovine immunodeficiency virus, feline immunodeficiency virus and Equine infectious anaemia (EIAV). The family also includes the Gp36 protein from mouse mammary tumor virus (MMTV) and human endogenous retroviruses (HERVs).",".",".",".",".","."]
["ENSRNOG00000019830",1268,106.6835206,5416,348.4136532,0.306197876,-1.707463819,0,0,"down","yes","Hsd17b1","protein_coding","chr10:86009728-86011927:+","gi|6981048|ref|NP_036983.1|",1809,0,"estradiol 17-beta-dehydrogenase 1 [Rattus norvegicus]","gi|402693121|ref|NM_012851.2|",1418,0,"Rattus norvegicus hydroxysteroid (17-beta) dehydrogenase 1 (Hsd17b1), mRNA","P51657",701,0,"Estradiol 17-beta-dehydrogenase 1","CAC3335",122,{"v":1e-30,"d":"1.00E-30"},"COG1028","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.","GO:0006703|estrogen biosynthetic process;GO:0060348|bone development;GO:0061370|testosterone biosynthetic process;GO:0071248|cellular response to metal ion;","GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004303|estradiol 17-beta-dehydrogenase activity;GO:0005496|steroid binding;GO:0030283|testosterone dehydrogenase [NAD(P)] activity;GO:0042803|protein homodimerization activity;GO:0044594|17-beta-hydroxysteroid dehydrogenase (NAD+) activity;GO:0047035|testosterone dehydrogenase (NAD+) activity;GO:0050661|NADP binding;GO:0070401|NADP+ binding;GO:0072582|17-beta-hydroxysteroid dehydrogenase (NADP+) activity;GO:1903924|estradiol binding;","K00044","HSD17B1; 17beta-estradiol 17-dehydrogenase [EC:1.1.1.62]"]
["ENSRNOG00000014963",1655,139.2438696,6051,389.2634815,0.357711104,-1.483133193,0,0,"down","yes","Adgrg1","protein_coding","chr19:10003975-10041108:-","gi|672084038|ref|XP_008770486.1|",3453,0,"PREDICTED: G-protein coupled receptor 56 isoform X2 [Rattus norvegicus]","gi|672084039|ref|XM_008772265.1|",3475,0,"PREDICTED: Rattus norvegicus G protein-coupled receptor 56 (Gpr56), transcript variant X2, mRNA","Q8K3V3",1311,0,"Adhesion G-protein coupled receptor G1",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0001525|angiogenesis;GO:0007155|cell adhesion;GO:0007166|cell surface receptor signaling pathway;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007266|Rho protein signal transduction;GO:0007420|brain development;GO:0008285|negative regulation of cell proliferation;GO:0010573|vascular endothelial growth factor production;GO:0016477|cell migration;GO:0021796|cerebral cortex regionalization;GO:0021801|cerebral cortex radial glia guided migration;GO:0021819|layer formation in cerebral cortex;GO:0035025|positive regulation of Rho protein signal transduction;GO:0045785|positive regulation of cell adhesion;GO:0061484|hematopoietic stem cell homeostasis;GO:0070528|protein kinase C signaling;GO:0072520|seminiferous tubule development;GO:2000179|positive regulation of neural precursor cell proliferation;GO:2001223|negative regulation of neuron migration;","GO:0005576|extracellular region;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;GO:0045121|membrane raft;GO:0097451|glial limiting end-foot;","GO:0004930|G protein-coupled receptor activity;GO:0005518|collagen binding;GO:0008201|heparin binding;GO:0050840|extracellular matrix binding;","K08450","ADGRG1, GPR56; adhesion G-protein coupled receptor G1"]
["ENSRNOG00000014117",1169,98.35412905,4706,302.7390421,0.324880889,-1.622017216,0,0,"down","yes","Hmox1","protein_coding","chr19:13467244-13474079:+","gi|6981032|ref|NP_036712.1|",1496,0,"heme oxygenase 1 [Rattus norvegicus]","gi|61098187|ref|NM_012580.2|",1494,0,"Rattus norvegicus heme oxygenase 1 (Hmox1), mRNA","P06762",559,0,"Heme oxygenase 1","sll1184",205,{"v":6e-61,"d":"6.00E-61"},"COG5398","pfam01126","Heme_oxygenase","Heme oxygenase.","GO:0001525|angiogenesis;GO:0001666|response to hypoxia;GO:0002246|wound healing involved in inflammatory response;GO:0006644|phospholipid metabolic process;GO:0006788|heme oxidation;GO:0006879|cellular iron ion homeostasis;GO:0006979|response to oxidative stress;GO:0007264|small GTPase mediated signal transduction;GO:0008217|regulation of blood pressure;GO:0008219|cell death;GO:0008285|negative regulation of cell proliferation;GO:0008630|intrinsic apoptotic signaling pathway in response to DNA damage;GO:0009410|response to xenobiotic stimulus;GO:0010656|negative regulation of muscle cell apoptotic process;GO:0016239|positive regulation of macroautophagy;GO:0016242|negative regulation of macroautophagy;GO:0031670|cellular response to nutrient;GO:0032764|negative regulation of mast cell cytokine production;GO:0034101|erythrocyte homeostasis;GO:0034395|regulation of transcription from RNA polymerase II promoter in response to iron;GO:0034605|cellular response to heat;GO:0035094|response to nicotine;GO:0035556|intracellular signal transduction;GO:0042167|heme catabolic process;GO:0042168|heme metabolic process;GO:0042542|response to hydrogen peroxide;GO:0043065|positive regulation of apoptotic process;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043305|negative regulation of mast cell degranulation;GO:0043392|negative regulation of DNA binding;GO:0043433|negative regulation of DNA-binding transcription factor activity;GO:0043524|negative regulation of neuron apoptotic process;GO:0043619|regulation of transcription from RNA polymerase II promoter in response to oxidative stress;GO:0043627|response to estrogen;GO:0043922|negative regulation by host of viral transcription;GO:0045766|positive regulation of angiogenesis;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0048662|negative regulation of smooth muscle cell proliferation;GO:0051090|regulation of DNA-binding transcription factor activity;GO:0055072|iron ion homeostasis;GO:0071243|cellular response to arsenic-containing substance;GO:0071276|cellular response to cadmium ion;GO:0071456|cellular response to hypoxia;GO:0072719|cellular response to cisplatin;GO:0090050|positive regulation of cell migration involved in sprouting angiogenesis;GO:0097421|liver regeneration;GO:1902042|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1903589|positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:1903901|negative regulation of viral life cycle;GO:1904036|negative regulation of epithelial cell apoptotic process;GO:1904706|negative regulation of vascular smooth muscle cell proliferation;","GO:0005634|nucleus;GO:0005730|nucleolus;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005901|caveola;GO:0048471|perinuclear region of cytoplasm;","GO:0004392|heme oxygenase (decyclizing) activity;GO:0004630|phospholipase D activity;GO:0005198|structural molecule activity;GO:0005515|protein binding;GO:0019899|enzyme binding;GO:0020037|heme binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0046872|metal ion binding;","K00510","HMOX1; heme oxygenase 1 [EC:1.14.14.18]"]
["ENSRNOG00000049911",973,81.86361639,4199,270.1235099,0.303059946,-1.722324903,0,0,"down","yes","Cbr1","protein_coding","chr11:32857991-32895275:+","gi|564376239|ref|XP_006248171.1|",1663,0,"PREDICTED: carbonyl reductase [NADPH] 1 [Rattus norvegicus]","gi|1217650|emb|X95986.1|",1480,0,"R.norvegicus CBR gene","P47727",546,0,"Carbonyl reductase [NADPH] 1","all0352",126,{"v":1e-30,"d":"1.00E-30"},"COG1028","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.",".",".","GO:0004090|carbonyl reductase (NADPH) activity;GO:0016491|oxidoreductase activity;","K00079","CBR1; carbonyl reductase 1 [EC:1.1.1.184 1.1.1.189 1.1.1.197]"]
["ENSRNOG00000020340",2113,177.7778226,6625,426.189153,0.417133616,-1.261418513,0,0,"down","yes","Brd8","protein_coding","chr18:26181732-26229884:-","gi|56606080|ref|NP_001008509.1|",4270,0,"bromodomain-containing protein 8 [Rattus norvegicus]","gi|56606079|ref|NM_001008509.1|",3282,0,"Rattus norvegicus bromodomain containing 8 (Brd8), mRNA","Q8R3B7",1523,0,"Bromodomain-containing protein 8","ECU08g1640",64.7,{"v":7e-10,"d":"7.00E-10"},"COG5076","pfam00439","Bromodomain","Bromodomain. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.","GO:0016573|histone acetylation;GO:0043967|histone H4 acetylation;GO:0043968|histone H2A acetylation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0097067|cellular response to thyroid hormone stimulus;","GO:0000812|Swr1 complex;GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005739|mitochondrion;GO:0035267|NuA4 histone acetyltransferase complex;","GO:0003674|molecular_function;GO:0030374|nuclear receptor transcription coactivator activity;GO:0046966|thyroid hormone receptor binding;","K11321","BRD8; bromodomain-containing protein 8"]
["ENSRNOG00000017243",944,79.4236936,4114,264.6554227,0.300102272,-1.736473854,0,0,"down","yes","Bnip3","protein_coding","chr1:193708167-193725359:-","gi|16758160|ref|NP_445872.1|",711,{"v":2e-84,"d":"2.00E-84"},"BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [Rattus norvegicus]","gi|186973219|gb|AC131400.5|",2082,0,"Rattus norvegicus BAC CH230-139P17 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","O55003",276,{"v":4e-85,"d":"4.00E-85"},"BCL2/adenovirus E1B 19 kDa protein-interacting protein 3",".",".",".",".","pfam06553","BNIP3","BNIP3. This family consists of several mammalian specific BCL2/adenovirus E1B 19-kDa protein-interacting protein 3 or BNIP3 sequences. BNIP3 belongs to the Bcl-2 homology 3 (BH3)-only family, a Bcl-2-related family possessing an atypical Bcl-2 homology 3 (BH3) domain, which regulates PCD from mitochondrial sites by selective Bcl-2/Bcl-XL interactions. BNIP3 family members contain a C-terminal transmembrane domain that is required for their mitochondrial localisation, homodimerization, as well as regulation of their pro-apoptotic activities. BNIP3-mediated apoptosis has been reported to be independent of caspase activation and cytochrome c release and is characterized by early plasma membrane and mitochondrial damage, prior to the appearance of chromatin condensation or DNA fragmentation.","GO:0001666|response to hypoxia;GO:0006915|apoptotic process;GO:0008219|cell death;GO:0009617|response to bacterium;GO:0010637|negative regulation of mitochondrial fusion;GO:0010659|cardiac muscle cell apoptotic process;GO:0010666|positive regulation of cardiac muscle cell apoptotic process;GO:0010821|regulation of mitochondrion organization;GO:0010917|negative regulation of mitochondrial membrane potential;GO:0010940|positive regulation of necrotic cell death;GO:0016239|positive regulation of macroautophagy;GO:0021987|cerebral cortex development;GO:0035694|mitochondrial protein catabolic process;GO:0043065|positive regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0043067|regulation of programmed cell death;GO:0043068|positive regulation of programmed cell death;GO:0043243|positive regulation of protein complex disassembly;GO:0043653|mitochondrial fragmentation involved in apoptotic process;GO:0045837|negative regulation of membrane potential;GO:0046902|regulation of mitochondrial membrane permeability;GO:0048102|autophagic cell death;GO:0048678|response to axon injury;GO:0048709|oligodendrocyte differentiation;GO:0050873|brown fat cell differentiation;GO:0051402|neuron apoptotic process;GO:0051561|positive regulation of mitochondrial calcium ion concentration;GO:0051607|defense response to virus;GO:0055093|response to hyperoxia;GO:0060548|negative regulation of cell death;GO:0070301|cellular response to hydrogen peroxide;GO:0071260|cellular response to mechanical stimulus;GO:0071279|cellular response to cobalt ion;GO:0071456|cellular response to hypoxia;GO:0072593|reactive oxygen species metabolic process;GO:0090141|positive regulation of mitochondrial fission;GO:0090200|positive regulation of release of cytochrome c from mitochondria;GO:0090649|response to oxygen-glucose deprivation;GO:0097193|intrinsic apoptotic signaling pathway;GO:0097345|mitochondrial outer membrane permeabilization;GO:1901998|toxin transport;GO:1902109|negative regulation of mitochondrial membrane permeability involved in apoptotic process;GO:1903599|positive regulation of autophagy of mitochondrion;GO:1903715|regulation of aerobic respiration;GO:1990144|intrinsic apoptotic signaling pathway in response to hypoxia;GO:2000378|negative regulation of reactive oxygen species metabolic process;","GO:0005634|nucleus;GO:0005635|nuclear envelope;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0005783|endoplasmic reticulum;GO:0014069|postsynaptic density;GO:0030425|dendrite;GO:0031307|integral component of mitochondrial outer membrane;GO:0031966|mitochondrial membrane;","GO:0005515|protein binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0051020|GTPase binding;","K15464","BNIP3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3"]
["ENSRNOG00000038297",124,10.43277331,1817,116.8884062,0.089254133,-3.485937219,{"v":5.2289e-306,"d":"5.23E-306"},{"v":3.1287e-304,"d":"3.13E-304"},"down","yes","Plekhd1","protein_coding","chr6:100340655-100371941:+","gi|189011673|ref|NP_001121038.1|",1926,0,"pleckstrin homology domain-containing family D member 1 [Rattus norvegicus]","gi|189011672|ref|NM_001127566.1|",3279,0,"Rattus norvegicus pleckstrin homology and coiled-coil domain containing D1 (Plekhd1), mRNA",".",".",".",".",".",".",".",".","pfam00169","PH","PH domain. PH stands for pleckstrin homology.",".",".",".",".","."]
["ENSRNOG00000056457",394,33.14929585,2662,171.2476264,0.193575213,-2.369033862,{"v":5.9784e-305,"d":"5.98E-305"},{"v":3.5382E-303,"d":"3.54E-303"},"down","yes","Gpd1","protein_coding","chr7:130844138-130851529:+","gi|57527919|ref|NP_071551.2|",1666,0,"glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic [Rattus norvegicus]","gi|564400292|ref|XM_006257376.1|",1859,0,"PREDICTED: Rattus norvegicus glycerol-3-phosphate dehydrogenase 1 (soluble) (Gpd1), transcript variant X1, mRNA","O35077",646,0,"Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic","SPBC215.05",326,{"v":2E-99,"d":"2.00E-99"},"COG0240","pfam01210","NAD_Gly3P_dh_N","NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus. NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyses the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain.","GO:0005975|carbohydrate metabolic process;GO:0006072|glycerol-3-phosphate metabolic process;GO:0006094|gluconeogenesis;GO:0006116|NADH oxidation;GO:0006127|glycerophosphate shuttle;GO:0006734|NADH metabolic process;GO:0045821|positive regulation of glycolytic process;GO:0046168|glycerol-3-phosphate catabolic process;GO:0046486|glycerolipid metabolic process;GO:0071320|cellular response to cAMP;GO:0071356|cellular response to tumor necrosis factor;","GO:0005829|cytosol;GO:0009331|glycerol-3-phosphate dehydrogenase complex;","GO:0004367|glycerol-3-phosphate dehydrogenase [NAD+] activity;GO:0004368|glycerol-3-phosphate dehydrogenase (quinone) activity;GO:0042803|protein homodimerization activity;GO:0051287|NAD binding;","K00006","GPD1; glycerol-3-phosphate dehydrogenase (NAD+) [EC:1.1.1.8]"]
["ENSRNOG00000012561",674,56.70717107,3253,209.2669154,0.270980107,-1.883741151,{"v":5.7473e-279,"d":"5.75E-279"},{"v":3.0983e-277,"d":"3.10E-277"},"down","yes","Arhgef10","protein_coding","chr16:74647153-74738173:-","gi|392354094|ref|XP_002728482.2|",6906,0,"PREDICTED: rho guanine nucleotide exchange factor 10 isoform X2 [Rattus norvegicus]","gi|672080638|ref|XM_006253400.2|",5569,0,"PREDICTED: Rattus norvegicus Rho guanine nucleotide exchange factor (GEF) 10 (Arhgef10), transcript variant X2, mRNA","Q8C033",2383,0,"Rho guanine nucleotide exchange factor 10","SPCC645.07",55.5,2e-06,"COG5422","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0022011|myelination in peripheral nervous system;GO:0030036|actin cytoskeleton organization;GO:0035023|regulation of Rho protein signal transduction;GO:0051298|centrosome duplication;GO:0051496|positive regulation of stress fiber assembly;GO:0090307|mitotic spindle assembly;GO:0090630|activation of GTPase activity;","GO:0005813|centrosome;GO:0005829|cytosol;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0019894|kinesin binding;","K16727","ARHGEF10; Rho guanine nucleotide exchange factor 10"]
["ENSRNOG00000020579",299,25.15644533,2234,143.7141989,0.175044954,-2.514202622,{"v":2.5686e-274,"d":"2.57E-274"},{"v":1.3578E-272,"d":"1.36E-272"},"down","yes","Col7a1","protein_coding","chr8:109604861-109637252:+","gi|157819015|ref|NP_001100328.1|",6441,0,"collagen alpha-1(VII) chain precursor [Rattus norvegicus]","gi|672062939|ref|XM_006243759.2|",9219,0,"PREDICTED: Rattus norvegicus collagen, type VII, alpha 1 (Col7a1), transcript variant X1, mRNA","Q63870",2256,0,"Collagen alpha-1(VII) chain",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0008150|biological_process;GO:0035987|endodermal cell differentiation;","GO:0005575|cellular_component;GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0062023|collagen-containing extracellular matrix;","GO:0003674|molecular_function;GO:0042802|identical protein binding;","K16628","COL7A; collagen type VII alpha"]
["ENSRNOG00000020361",2507,210.9271185,7036,452.6289631,0.466004467,-1.101584312,{"v":1.0389E-270,"d":"1.04E-270"},{"v":5.2866E-269,"d":"5.29E-269"},"down","yes","Ip6k2","protein_coding","chr8:109484310-109510166:+","gi|961743782|ref|XP_014932518.1|",2223,0,"PREDICTED: inositol hexakisphosphate kinase 2 isoform X1 [Acinonyx jubatus]","gi|672063133|ref|XM_008766564.1|",1550,0,"PREDICTED: Rattus norvegicus inositol hexakisphosphate kinase 2 (Ip6k2), transcript variant X1, mRNA","Q9R0U1",843,0,"Inositol hexakisphosphate kinase 2",".",".",".",".","pfam03770","IPK","Inositol polyphosphate kinase. ArgRIII has has been demonstrated to be an inositol polyphosphate kinase.","GO:0006817|phosphate ion transport;GO:0016310|phosphorylation;GO:0030308|negative regulation of cell growth;GO:0032958|inositol phosphate biosynthetic process;GO:0043065|positive regulation of apoptotic process;GO:0043647|inositol phosphate metabolic process;GO:0046854|phosphatidylinositol phosphorylation;GO:1905396|cellular response to flavonoid;","GO:0001650|fibrillar center;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0030054|cell junction;","GO:0000828|inositol hexakisphosphate kinase activity;GO:0000832|inositol hexakisphosphate 5-kinase activity;GO:0005524|ATP binding;GO:0016301|kinase activity;GO:0097243|flavonoid binding;","K07756","IP6K, IHPK; inositol-hexakisphosphate 5-kinase [EC:2.7.4.21]"]
["ENSRNOG00000050317",1556,130.914478,5103,328.2782261,0.398791231,-1.326294407,{"v":2.565E-263,"d":"2.57E-263"},{"v":1.2582e-261,"d":"1.26E-261"},"down","yes","Uhrf1bp1l","protein_coding","chr7:24181644-24261720:+","gi|157816897|ref|NP_001102223.1|",7599,0,"UHRF1-binding protein 1-like [Rattus norvegicus]","gi|157816896|ref|NM_001108753.1|",7053,0,"Rattus norvegicus UHRF1 binding protein 1-like (Uhrf1bp1l), mRNA","A2RSJ4",2660,0,"UHRF1-binding protein 1-like",".",".",".",".","pfam12624","Chorein_N","N-terminal region of Chorein, a TM vesicle-mediated sorter. Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.",".","GO:0005769|early endosome;GO:0005829|cytosol;","GO:0042803|protein homodimerization activity;GO:0062069|GARP complex binding;",".","."]
["ENSRNOG00000053239",471,39.62771153,2544,163.6566347,0.242139352,-2.046090531,{"v":1.4148e-243,"d":"1.41E-243"},{"v":6.2627e-242,"d":"6.26E-242"},"down","yes","Clmp","protein_coding","chr8:41060799-41168838:+","gi|35215304|ref|NP_775177.1|",1573,0,"CXADR-like membrane protein precursor [Rattus norvegicus]","gi|35215303|ref|NM_173154.1|",3862,0,"Rattus norvegicus CXADR-like membrane protein (Clmp), mRNA","Q8K1G0",610,0,"CXADR-like membrane protein",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0008150|biological_process;GO:0048565|digestive tract development;","GO:0005881|cytoplasmic microtubule;GO:0005886|plasma membrane;GO:0005923|bicellular tight junction;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;","K06789","ASAM, CLMP; adipocyte-specific adhesion molecule"]
["ENSRNOG00000015441",1512,127.2125262,4820,310.0727121,0.410266758,-1.285365832,{"v":3.7701e-237,"d":"3.77E-237"},{"v":1.6292e-235,"d":"1.63E-235"},"down","yes","Il4r","protein_coding","chr1:180115120-180139980:+","gi|158534071|ref|NP_596871.2|",3755,0,"interleukin-4 receptor subunit alpha precursor [Rattus norvegicus]","gi|158534070|ref|NM_133380.2|",3346,0,"Rattus norvegicus interleukin 4 receptor (Il4r), mRNA","Q63257",1451,0,"Interleukin-4 receptor subunit alpha",".",".",".",".","pfam09238","IL4Ra_N","Interleukin-4 receptor alpha chain, N-terminal. Members of this family are related in overall topology to fibronectin type III modules and fold into a sandwich comprising seven antiparallel beta sheets arranged in a three-strand and a four-strand beta-pleated sheet. They are required for binding of interleukin-4 to the receptor alpha chain, which is a crucial event for the generation of a Th2-dominated early immune response.","GO:0002532|production of molecular mediator involved in inflammatory response;GO:0002639|positive regulation of immunoglobulin production;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0016064|immunoglobulin mediated immune response;GO:0019221|cytokine-mediated signaling pathway;GO:0030728|ovulation;GO:0032722|positive regulation of chemokine production;GO:0042127|regulation of cell proliferation;GO:0042832|defense response to protozoan;GO:0043032|positive regulation of macrophage activation;GO:0043306|positive regulation of mast cell degranulation;GO:0043627|response to estrogen;GO:0045626|negative regulation of T-helper 1 cell differentiation;GO:0045630|positive regulation of T-helper 2 cell differentiation;GO:0120162|positive regulation of cold-induced thermogenesis;GO:1901741|positive regulation of myoblast fusion;GO:1990834|response to odorant;","GO:0005615|extracellular space;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0034451|centriolar satellite;GO:0043235|receptor complex;","GO:0003674|molecular_function;GO:0004896|cytokine receptor activity;GO:0044877|protein-containing complex binding;","K05071","IL4R, CD124; interleukin 4 receptor"]
["ENSRNOG00000047321",629,52.92108398,2897,186.3652794,0.283964289,-1.816218588,{"v":9.7142E-237,"d":"9.71E-237"},{"v":4.1648e-235,"d":"4.16E-235"},"down","yes","Hba-a3","protein_coding","chr10:15311634-15312481:-","gi|62078447|ref|NP_001013875.1|",742,{"v":7e-98,"d":"7.00E-98"},"hemoglobin alpha, adult chain 1 [Rattus norvegicus]","gi|298900691|emb|FQ212394.1|",545,0,"Rattus norvegicus TL0AAA56YK17 mRNA sequence","P01944",235,{"v":9e-78,"d":"9.00E-78"},"Hemoglobin subunit alpha",".",".",".",".","pfam00042","Globin","Globin.","GO:0001701|in utero embryonic development;GO:0009617|response to bacterium;GO:0010942|positive regulation of cell death;GO:0015671|oxygen transport;GO:0032355|response to estradiol;GO:0042542|response to hydrogen peroxide;GO:0042744|hydrogen peroxide catabolic process;GO:0048821|erythrocyte development;GO:0098869|cellular oxidant detoxification;","GO:0005615|extracellular space;GO:0005833|hemoglobin complex;GO:0022627|cytosolic small ribosomal subunit;GO:0031838|haptoglobin-hemoglobin complex;","GO:0003674|molecular_function;GO:0004601|peroxidase activity;GO:0005344|oxygen carrier activity;GO:0005506|iron ion binding;GO:0005515|protein binding;GO:0019825|oxygen binding;GO:0020037|heme binding;GO:0031720|haptoglobin binding;GO:0043177|organic acid binding;","K13822","HBA; hemoglobin subunit alpha"]
["ENSRNOG00000006709",38,3.197140209,1160,74.62330829,0.042843721,-4.544772402,{"v":1.3576E-230,"d":"1.36E-230"},{"v":5.5577e-229,"d":"5.56E-229"},"down","yes","Pzp","protein_coding","chr4:161759182-161805276:-","gi|307746876|ref|NP_665722.2|",7768,0,"alpha-1-macroglobulin precursor [Rattus norvegicus]","gi|307746875|ref|NM_145779.2|",2925,0,"Rattus norvegicus pregnancy-zone protein (Pzp), mRNA","Q63041",2972,0,"Alpha-1-macroglobulin","TM0984",84,{"v":3e-15,"d":"3.00E-15"},"COG2373","pfam07678","A2M_comp","A-macroglobulin complement component. This family includes the complement components region of the alpha-2-macroglobulin family.","GO:0007566|embryo implantation;GO:0010951|negative regulation of endopeptidase activity;","GO:0005615|extracellular space;","GO:0002020|protease binding;GO:0004866|endopeptidase inhibitor activity;GO:0004867|serine-type endopeptidase inhibitor activity;GO:0044877|protein-containing complex binding;GO:0048403|brain-derived neurotrophic factor binding;GO:0048406|nerve growth factor binding;","K23589","PZP; pregnancy zone protein"]
["ENSRNOG00000006052",2321,195.2779585,6338,407.7263172,0.478943719,-1.062071962,{"v":4.0715e-230,"d":"4.07E-230"},{"v":1.6544e-228,"d":"1.65E-228"},"down","yes","Sulf2","protein_coding","chr3:154822085-154904415:-","gi|672048121|ref|XP_008760728.1|",4655,0,"PREDICTED: extracellular sulfatase Sulf-2 isoform X2 [Rattus norvegicus]","gi|110626130|ref|NM_001034927.1|",4172,0,"Rattus norvegicus sulfatase 2 (Sulf2), mRNA","Q8CFG0",1685,0,"Extracellular sulfatase Sulf-2","yidJ",95.9,{"v":2E-19,"d":"2.00E-19"},"COG3119","pfam12548","DUF3740","Sulfatase protein. This domain family is found in eukaryotes, and is typically between 144 and 173 amino acids in length. The family is found in association with pfam00884.","GO:0001822|kidney development;GO:0002063|chondrocyte development;GO:0003094|glomerular filtration;GO:0009611|response to wounding;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0014846|esophagus smooth muscle contraction;GO:0030177|positive regulation of Wnt signaling pathway;GO:0030201|heparan sulfate proteoglycan metabolic process;GO:0032836|glomerular basement membrane development;GO:0035860|glial cell-derived neurotrophic factor receptor signaling pathway;GO:0040037|negative regulation of fibroblast growth factor receptor signaling pathway;GO:0048706|embryonic skeletal system development;GO:0051216|cartilage development;GO:0060348|bone development;GO:0060384|innervation;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:0097421|liver regeneration;GO:2000345|regulation of hepatocyte proliferation;","GO:0005615|extracellular space;GO:0005783|endoplasmic reticulum;GO:0005795|Golgi stack;GO:0005886|plasma membrane;GO:0009986|cell surface;","GO:0004065|arylsulfatase activity;GO:0005509|calcium ion binding;GO:0005539|glycosaminoglycan binding;GO:0008449|N-acetylglucosamine-6-sulfatase activity;","K14607","SULF; extracellular sulfatase Sulf [EC:3.1.6.-]"]
["ENSRNOG00000018987",1340,112.74126,4344,279.4514235,0.403437773,-1.309581928,{"v":3.739e-220,"d":"3.74E-220"},{"v":1.4337e-218,"d":"1.43E-218"},"down","yes","Crebzf","protein_coding","chr1:144417446-144428553:+","gi|422398900|ref|NP_001258720.1|",1164,{"v":1E-139,"d":"1.00E-139"},"CREB/ATF bZIP transcription factor [Rattus norvegicus]","gi|422399058|ref|NR_073439.1|",5065,0,"Rattus norvegicus CREB/ATF bZIP transcription factor (Crebzf), transcript variant 2, non-coding RNA","Q91ZR3",408,{"v":1E-125,"d":"1.00E-125"},"CREB/ATF bZIP transcription factor",".",".",".",".","pfam07114","DUF1370","Protein of unknown function (DUF1370). This family consists of several hypothetical eukaryotic proteins of around 200 residues in length. Members of this family seem to be specific to mammals and their function is unknown.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0009615|response to virus;GO:0045814|negative regulation of gene expression, epigenetic;GO:0045892|negative regulation of transcription, DNA-templated;GO:0051090|regulation of DNA-binding transcription factor activity;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005739|mitochondrion;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0042802|identical protein binding;","K21548","CREBZF; ATF/CREB family transcription factor"]
["ENSRNOG00000068605",274,23.05306361,1866,120.0405977,0.192043892,-2.380492013,{"v":1.3177e-215,"d":"1.32E-215"},{"v":4.9141e-214,"d":"4.91E-214"},"down","yes","ENSRNOG00000068605","protein_coding","chr1:7387083-7395497:+","gi|148676020|gb|EDL07967.1|",1100,{"v":9e-135,"d":"9.00E-135"},"mCG1029965 [Mus musculus]","gi|46240867|gb|AC107531.8|",2360,0,"Rattus norvegicus 1 BAC CH230-158N3 (Children's Hospital Oakland Research Institute) complete sequence","P31789",197,{"v":3E-52,"d":"3.00E-52"},"Envelope glycoprotein",".",".",".",".","pfam11822","DUF3342","Domain of unknown function (DUF3342). This family of proteins are functionally uncharacterized. This family is found in bacteria. This presumed domain is typically between 170 to 303 amino acids in length. The N-terminal half of this family is a BTB-like domain.",".",".",".",".","."]
["ENSRNOG00000021027",1045,87.92135574,3682,236.8646734,0.371188132,-1.42977751,{"v":2.0639e-213,"d":"2.06E-213"},{"v":7.6445e-212,"d":"7.64E-212"},"down","yes","Dbp","protein_coding","chr1:96175440-96180745:+","gi|7549756|ref|NP_036675.1|",1054,{"v":9e-132,"d":"9.00E-132"},"D site-binding protein isoform 1 [Rattus norvegicus]","gi|88023877|gb|AC136191.5|",2150,0,"Rattus norvegicus BAC CH230-52I17 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P16443",406,{"v":9e-132,"d":"9.00E-132"},"D site-binding protein",".",".",".",".","pfam07716","bZIP_2","Basic region leucine zipper.","GO:0001889|liver development;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007623|circadian rhythm;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:1990837|sequence-specific double-stranded DNA binding;","K09056","DBP; albumin D box-binding protein"]
["ENSRNOG00000029212",1727,145.301609,5053,325.0617041,0.446997007,-1.161662922,{"v":3.4616e-212,"d":"3.46E-212"},{"v":1.2735E-210,"d":"1.27E-210"},"down","yes","Vcan","protein_coding","chr2:20761718-20860637:-","gi|281604090|ref|NP_001164029.1|",16820,0,"versican core protein isoform 1 precursor [Rattus norvegicus]","gi|281604089|ref|NM_001170558.1|",12234,0,"Rattus norvegicus versican (Vcan), transcript variant 1, mRNA","Q62059",5300,0,"Versican core protein",".",".",".",".","pfam00193","Xlink","Extracellular link domain.","GO:0001501|skeletal system development;GO:0001657|ureteric bud development;GO:0007155|cell adhesion;GO:0007417|central nervous system development;GO:0007507|heart development;GO:0008347|glial cell migration;GO:0009611|response to wounding;GO:0031103|axon regeneration;","GO:0001750|photoreceptor outer segment;GO:0005576|extracellular region;GO:0009986|cell surface;GO:0031012|extracellular matrix;GO:0033165|interphotoreceptor matrix;GO:0045202|synapse;GO:0062023|collagen-containing extracellular matrix;GO:0072534|perineuronal net;","GO:0005509|calcium ion binding;GO:0005540|hyaluronic acid binding;GO:0019903|protein phosphatase binding;GO:0030169|low-density lipoprotein particle binding;GO:0030246|carbohydrate binding;","K06793","VCAN, CSPG2; versican core protein"]
["ENSRNOG00000007682",704,59.23122913,2841,182.7627749,0.324088038,-1.625542323,{"v":5.1024e-199,"d":"5.10E-199"},{"v":1.804E-197,"d":"1.80E-197"},"down","yes","ENSRNOG00000007682","protein_coding","chrX:120238534-120504096:+","gi|60360568|dbj|BAD90527.1|",4554,0,"mKIAA4184 protein [Mus musculus]","gi|163792202|ref|NM_032990.2|",5024,0,"Rattus norvegicus glutamate ionotropic receptor AMPA type subunit 3 (Gria3), transcript variant 1, mRNA","Q9Z2W9",1725,0,"Glutamate receptor 3",".",".",".",".","pfam00060","Lig_chan","Ligand-gated ion channel. This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.","GO:0001919|regulation of receptor recycling;GO:0010226|response to lithium ion;GO:0034220|ion transmembrane transport;GO:0035235|ionotropic glutamate receptor signaling pathway;GO:0060078|regulation of postsynaptic membrane potential;GO:0060992|response to fungicide;","GO:0005886|plasma membrane;GO:0008328|ionotropic glutamate receptor complex;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0032279|asymmetric synapse;GO:0032281|AMPA glutamate receptor complex;GO:0032991|protein-containing complex;GO:0043025|neuronal cell body;GO:0043083|synaptic cleft;GO:0043195|terminal bouton;GO:0043197|dendritic spine;GO:0043198|dendritic shaft;GO:0043204|perikaryon;GO:0045211|postsynaptic membrane;GO:0098688|parallel fiber to Purkinje cell synapse;GO:0098978|glutamatergic synapse;GO:0099055|integral component of postsynaptic membrane;GO:0099056|integral component of presynaptic membrane;GO:0099061|integral component of postsynaptic density membrane;","GO:0001540|amyloid-beta binding;GO:0004970|ionotropic glutamate receptor activity;GO:0004971|AMPA glutamate receptor activity;GO:0005515|protein binding;GO:0015276|ligand-gated ion channel activity;GO:0030165|PDZ domain binding;GO:0038023|signaling receptor activity;GO:1904315|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K05199","GRIA3; glutamate receptor 3"]
["ENSRNOG00000007808",121,10.18036751,1317,84.72318709,0.120160346,-3.056967218,{"v":1.1558E-198,"d":"1.16E-198"},{"v":4.06e-197,"d":"4.06E-197"},"down","yes","Nap1l5","protein_coding","chr4:88022569-88024654:-","gi|149033227|gb|EDL88028.1|",836,{"v":3e-104,"d":"3.00E-104"},"rCG52514 [Rattus norvegicus]","gi|112983817|ref|NM_001044293.1|",1606,0,"Rattus norvegicus nucleosome assembly protein 1-like 5 (Nap1l5), mRNA","Q5PPG6",195,{"v":3E-57,"d":"3.00E-57"},"Nucleosome assembly protein 1-like 5",".",".",".",".","pfam00956","NAP","Nucleosome assembly protein (NAP). NAP proteins are involved in moving histones into the nucleus, nucleosome assembly and chromatin fluidity. They affect the transcription of many genes.","GO:0006334|nucleosome assembly;","GO:0000785|chromatin;GO:0005634|nucleus;","GO:0003682|chromatin binding;GO:0042393|histone binding;","K11283","NAP1L5; nucleosome assembly protein 1-like 5"]
["ENSRNOG00000002292",1481,124.6043329,4439,285.5628151,0.436346493,-1.196453893,{"v":1.5837E-195,"d":"1.58E-195"},{"v":5.4925e-194,"d":"5.49E-194"},"down","yes","Hnrnpd","protein_coding","chr14:9615479-9633786:+","gi|127138710|ref|NP_077380.2|",1086,{"v":9e-141,"d":"9.00E-141"},"heterogeneous nuclear ribonucleoprotein D0 isoform a [Rattus norvegicus]","gi|127138709|ref|NM_024404.2|",1698,0,"Rattus norvegicus heterogeneous nuclear ribonucleoprotein D (Hnrnpd), transcript variant 1, mRNA","Q9JJ54",422,{"v":3e-142,"d":"3.00E-142"},"Heterogeneous nuclear ribonucleoprotein D0",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0000291|nuclear-transcribed mRNA catabolic process, exonucleolytic;GO:0001889|liver development;GO:0006913|nucleocytoplasmic transport;GO:0007420|brain development;GO:0009410|response to xenobiotic stimulus;GO:0010468|regulation of gene expression;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0021549|cerebellum development;GO:0032204|regulation of telomere maintenance;GO:0032355|response to estradiol;GO:0042752|regulation of circadian rhythm;GO:0042789|mRNA transcription by RNA polymerase II;GO:0043488|regulation of mRNA stability;GO:0045727|positive regulation of translation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048255|mRNA stabilization;GO:0051592|response to calcium ion;GO:0051602|response to electrical stimulus;GO:0061158|3'-UTR-mediated mRNA destabilization;GO:0071230|cellular response to amino acid stimulus;GO:0071392|cellular response to estradiol stimulus;GO:0071732|cellular response to nitric oxide;GO:0097167|circadian regulation of translation;GO:1901355|response to rapamycin;GO:1904355|positive regulation of telomere capping;GO:1904383|response to sodium phosphate;GO:1904586|cellular response to putrescine;GO:1905663|positive regulation of telomerase RNA reverse transcriptase activity;GO:1990828|hepatocyte dedifferentiation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0045202|synapse;GO:1990904|ribonucleoprotein complex;","GO:0003680|AT DNA binding;GO:0003682|chromatin binding;GO:0003723|RNA binding;GO:0003729|mRNA binding;GO:0005515|protein binding;GO:0035925|mRNA 3'-UTR AU-rich region binding;GO:0042162|telomeric DNA binding;GO:0042826|histone deacetylase binding;","K13044","HNRNPABD; heterogeneous nuclear ribonucleoprotein A/B/D"]
["ENSRNOG00000029450",157,13.20923718,1409,90.6415874,0.145730426,-2.778625973,{"v":1.94e-193,"d":"1.94E-193"},{"v":6.6435E-192,"d":"6.64E-192"},"down","yes","Adgrb1","protein_coding","chr7:106404958-106476902:+","gi|294345428|ref|NP_001164068.2|",7384,0,"brain-specific angiogenesis inhibitor 1 precursor [Rattus norvegicus]","gi|294345427|ref|NM_001170597.2|",5511,0,"Rattus norvegicus brain-specific angiogenesis inhibitor 1 (Bai1), mRNA","C0HL12",2848,0,"Adhesion G protein-coupled receptor B1",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0006910|phagocytosis, recognition;GO:0006911|phagocytosis, engulfment;GO:0007166|cell surface receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007399|nervous system development;GO:0007517|muscle organ development;GO:0010596|negative regulation of endothelial cell migration;GO:0016525|negative regulation of angiogenesis;GO:0031397|negative regulation of protein ubiquitination;GO:0042177|negative regulation of protein catabolic process;GO:0043277|apoptotic cell clearance;GO:0043652|engulfment of apoptotic cell;GO:0045087|innate immune response;GO:0048167|regulation of synaptic plasticity;GO:0050829|defense response to Gram-negative bacterium;GO:0051963|regulation of synapse assembly;GO:0051965|positive regulation of synapse assembly;GO:0098974|postsynaptic actin cytoskeleton organization;GO:1901741|positive regulation of myoblast fusion;GO:1903428|positive regulation of reactive oxygen species biosynthetic process;","GO:0001891|phagocytic cup;GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005925|focal adhesion;GO:0014069|postsynaptic density;GO:0030425|dendrite;GO:0043197|dendritic spine;GO:0048471|perinuclear region of cytoplasm;GO:0098978|glutamatergic synapse;GO:0099055|integral component of postsynaptic membrane;","GO:0001530|lipopolysaccharide binding;GO:0001786|phosphatidylserine binding;GO:0004888|transmembrane signaling receptor activity;GO:0004930|G protein-coupled receptor activity;GO:0005515|protein binding;GO:0030165|PDZ domain binding;","K04596","ADGRB1, BAI1; adhesion G protein-coupled receptor B1"]
["ENSRNOG00000032401",279,23.47373995,1730,111.2916581,0.210920929,-2.245225836,{"v":1.2237E-186,"d":"1.22E-186"},{"v":4.0138e-185,"d":"4.01E-185"},"down","yes","H3f3c","protein_coding","chr7:86501071-86502140:+","gi|755472894|ref|XP_006543746.2|",760,{"v":1e-96,"d":"1.00E-96"},"PREDICTED: LOW QUALITY PROTEIN: histone H3.3C isoform X1 [Mus musculus]","gi|672021859|ref|XM_003754308.3|",1050,0,"PREDICTED: Rattus norvegicus H3 histone, family 3C (H3f3c), mRNA","Q6P823",271,{"v":2e-89,"d":"2.00E-89"},"Histone H3.3",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.","GO:0001649|osteoblast differentiation;GO:0006334|nucleosome assembly;GO:0006336|DNA replication-independent nucleosome assembly;GO:0007283|spermatogenesis;GO:0007338|single fertilization;GO:0008150|biological_process;GO:0008283|cell proliferation;GO:0030307|positive regulation of cell growth;GO:0031508|pericentric heterochromatin assembly;GO:0031509|telomeric heterochromatin assembly;GO:0035264|multicellular organism growth;GO:0042692|muscle cell differentiation;GO:0048477|oogenesis;GO:1902340|negative regulation of chromosome condensation;","GO:0000228|nuclear chromosome;GO:0000781|chromosome, telomeric region;GO:0000786|nucleosome;GO:0001740|Barr body;GO:0005575|cellular_component;GO:0005634|nucleus;GO:0032991|protein-containing complex;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000979|RNA polymerase II core promoter sequence-specific DNA binding;GO:0003674|molecular_function;GO:0031492|nucleosomal DNA binding;GO:0046982|protein heterodimerization activity;","K11253","H3; histone H3"]
["ENSRNOG00000028822",1520,127.8856083,4422,284.4691977,0.44955872,-1.153418527,{"v":7.2913E-184,"d":"7.29E-184"},{"v":2.3491E-182,"d":"2.35E-182"},"down","yes","ENSRNOG00000028822","protein_coding","chrX:99273161-99274800:+","gi|625261828|ref|XP_007622341.1|",580,{"v":3e-70,"d":"3.00E-70"},"PREDICTED: protein BEX3 isoform X2 [Cricetulus griseus]","gi|672088096|ref|XM_006257257.2|",672,0,"PREDICTED: Rattus norvegicus nerve growth factor receptor (TNFRSF16) associated protein 1 (Ngfrap1), transcript variant X1, mRNA","Q6PDU5",171,{"v":2E-50,"d":"2.00E-50"},"Protein BEX3",".",".",".",".","pfam04538","BEX","Brain expressed X-linked like family. This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.","GO:0007165|signal transduction;GO:0008150|biological_process;GO:0008625|extrinsic apoptotic signaling pathway via death domain receptors;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0005102|signaling receptor binding;GO:0005123|death receptor binding;GO:0005163|nerve growth factor receptor binding;GO:0005515|protein binding;GO:0042802|identical protein binding;GO:0046872|metal ion binding;","K12465","NGFRAP1; nerve growth factor receptor-associated protein 1"]
["ENSRNOG00000005371",1915,161.1190395,5140,330.6584523,0.487267264,-1.037214793,{"v":5.6095e-180,"d":"5.61E-180"},{"v":1.7861e-178,"d":"1.79E-178"},"down","yes","Klhl29","protein_coding","chr6:28086489-28390647:-","gi|28972876|dbj|BAC65854.1|",4441,0,"mKIAA1921 protein [Mus musculus]","gi|256818757|ref|NM_001106713.2|",6980,0,"Rattus norvegicus kelch-like family member 29 (Klhl29), mRNA","Q80T74",1571,0,"Kelch-like protein 29",".",".",".",".","pfam07707","BACK","BTB And C-terminal Kelch. This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).",".",".",".","K10465","KLHL29, KBTBD9; kelch-like protein 29"]
["ENSRNOG00000019587",162,13.62991352,1335,85.88113498,0.158706723,-2.655564849,{"v":6.7193e-175,"d":"6.72E-175"},{"v":2.0787e-173,"d":"2.08E-173"},"down","yes","Ptprn","protein_coding","chr9:76741016-76756190:-","gi|564368872|ref|XP_006245196.1|",4282,0,"PREDICTED: receptor-type tyrosine-protein phosphatase-like N isoform X1 [Rattus norvegicus]","gi|672065437|ref|XM_006245134.2|",3515,0,"PREDICTED: Rattus norvegicus protein tyrosine phosphatase, receptor type, N (Ptprn), transcript variant X1, mRNA","Q63259",1647,0,"Receptor-type tyrosine-protein phosphatase-like N","SPAC26F1.10c",135,{"v":4e-32,"d":"4.00E-32"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0000302|response to reactive oxygen species;GO:0001553|luteinization;GO:0009749|response to glucose;GO:0019221|cytokine-mediated signaling pathway;GO:0019932|second-messenger-mediated signaling;GO:0030073|insulin secretion;GO:0032868|response to insulin;GO:0035773|insulin secretion involved in cellular response to glucose stimulus;GO:0043627|response to estrogen;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051591|response to cAMP;GO:1904692|positive regulation of type B pancreatic cell proliferation;GO:1990502|dense core granule maturation;","GO:0005634|nucleus;GO:0005768|endosome;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030141|secretory granule;GO:0030658|transport vesicle membrane;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0043679|axon terminus;GO:0045202|synapse;","GO:0030507|spectrin binding;GO:0044389|ubiquitin-like protein ligase binding;GO:0051020|GTPase binding;","K07817","PTPRN; receptor-type tyrosine-protein phosphatase N [EC:3.1.3.48]"]
["ENSRNOG00000059461",534,44.92823346,2283,146.8663904,0.305912288,-1.708810038,{"v":5.4927e-172,"d":"5.49E-172"},{"v":1.6708E-170,"d":"1.67E-170"},"down","yes","B4galt1","protein_coding","chr5:55935615-55982461:-","gi|158081739|ref|NP_445739.1|",2043,0,"beta-1,4-galactosyltransferase 1 [Rattus norvegicus]","gi|158081738|ref|NM_053287.1|",2291,0,"Rattus norvegicus UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 (B4galt1), mRNA","P15535",756,0,"Beta-1,4-galactosyltransferase 1",".",".",".",".","pfam13733","Glyco_transf_7N","N-terminal region of glycosyl transferase group 7. This is the N-terminal half of a family of galactosyltransferases from a wide range of Metazoa with three related galactosyltransferases activities, all three of which are possessed by one sequence in some cases. EC:2.4.1.90, N-acetyllactosamine synthase; EC:2.4.1.38, Beta-N-acetylglucosaminyl-glycopeptide beta-1,4- galactosyltransferase; and EC:2.4.1.22 Lactose synthase. Note that N-acetyllactosamine synthase is a component of Lactose synthase along with alpha-lactalbumin, in the absence of alpha-lactalbumin EC:2.4.1.90 is the catalysed reaction.","GO:0002064|epithelial cell development;GO:0002526|acute inflammatory response;GO:0005989|lactose biosynthetic process;GO:0006012|galactose metabolic process;GO:0006486|protein glycosylation;GO:0006487|protein N-linked glycosylation;GO:0007155|cell adhesion;GO:0007160|cell-matrix adhesion;GO:0007339|binding of sperm to zona pellucida;GO:0007341|penetration of zona pellucida;GO:0008285|negative regulation of cell proliferation;GO:0009101|glycoprotein biosynthetic process;GO:0009312|oligosaccharide biosynthetic process;GO:0009611|response to wounding;GO:0030198|extracellular matrix organization;GO:0030879|mammary gland development;GO:0042060|wound healing;GO:0042127|regulation of cell proliferation;GO:0043065|positive regulation of apoptotic process;GO:0045136|development of secondary sexual characteristics;GO:0048754|branching morphogenesis of an epithelial tube;GO:0050900|leukocyte migration;GO:0051270|regulation of cellular component movement;GO:0060046|regulation of acrosome reaction;GO:0060054|positive regulation of epithelial cell proliferation involved in wound healing;GO:0060055|angiogenesis involved in wound healing;GO:0060058|positive regulation of apoptotic process involved in mammary gland involution;GO:0070085|glycosylation;","GO:0000138|Golgi trans cisterna;GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0030057|desmosome;GO:0030175|filopodium;GO:0031526|brush border membrane;GO:0032580|Golgi cisterna membrane;","GO:0003674|molecular_function;GO:0003831|beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity;GO:0003945|N-acetyllactosamine synthase activity;GO:0004461|lactose synthase activity;GO:0008092|cytoskeletal protein binding;GO:0008378|galactosyltransferase activity;GO:0030145|manganese ion binding;GO:0035250|UDP-galactosyltransferase activity;GO:0042802|identical protein binding;GO:0043014|alpha-tubulin binding;GO:0048487|beta-tubulin binding;GO:0098638|laminin binding involved in cell-matrix adhesion;","K07966","B4GALT1; beta-1,4-galactosyltransferase 1 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-]"]
["ENSRNOG00000036913",1148,96.58728841,3588,230.8176122,0.418457186,-1.256848074,{"v":4.8263e-171,"d":"4.83E-171"},{"v":1.4439E-169,"d":"1.44E-169"},"down","yes","Resf1","protein_coding","chr4:182335454-182362054:+","gi|149048910|gb|EDM01364.1|",7283,0,"rCG29614 [Rattus norvegicus]","gi|672051701|ref|XR_353788.2|",4855,0,"PREDICTED: Rattus norvegicus similar to hypothetical protein FLJ10652 (RGD1309621), transcript variant X9, misc_RNA",".",".",".",".",".",".",".",".","pfam15395","DUF4617","Domain of unknown function (DUF4617). This family of proteins is found in eukaryotes. Proteins in this family are typically between 702 and 1745 amino acids in length.","GO:0009617|response to bacterium;GO:0045869|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate;GO:0090309|positive regulation of methylation-dependent chromatin silencing;","GO:0000930|gamma-tubulin complex;GO:0005634|nucleus;","GO:1990226|histone methyltransferase binding;",".","."]
["ENSRNOG00000018059",256,21.53862877,1580,101.6420923,0.211906586,-2.238499668,{"v":5.1234e-170,"d":"5.12E-170"},{"v":1.5161e-168,"d":"1.52E-168"},"down","yes","Ihh","protein_coding","chr9:76504315-76510532:-","gi|1890097|gb|AAB49692.1|",2045,0,"Indian hedgehog protein [Mus musculus]","gi|213688397|ref|NM_053384.1|",2272,0,"Rattus norvegicus Indian hedgehog (Ihh), mRNA","P97812",726,0,"Indian hedgehog protein",".",".",".",".","pfam01085","HH_signal","Hedgehog amino-terminal signalling domain. For the carboxyl Hint module, see pfam01079. Hedgehog is a family of secreted signal molecules required for embryonic cell differentiation.","GO:0001501|skeletal system development;GO:0001503|ossification;GO:0001569|branching involved in blood vessel morphogenesis;GO:0001649|osteoblast differentiation;GO:0001701|in utero embryonic development;GO:0001708|cell fate specification;GO:0001763|morphogenesis of a branching structure;GO:0001944|vasculature development;GO:0001947|heart looping;GO:0002053|positive regulation of mesenchymal cell proliferation;GO:0003382|epithelial cell morphogenesis;GO:0003406|retinal pigment epithelium development;GO:0003413|chondrocyte differentiation involved in endochondral bone morphogenesis;GO:0006029|proteoglycan metabolic process;GO:0007224|smoothened signaling pathway;GO:0007267|cell-cell signaling;GO:0007389|pattern specification process;GO:0008284|positive regulation of cell proliferation;GO:0009612|response to mechanical stimulus;GO:0009880|embryonic pattern specification;GO:0010468|regulation of gene expression;GO:0016539|intein-mediated protein splicing;GO:0016540|protein autoprocessing;GO:0030154|cell differentiation;GO:0030704|vitelline membrane formation;GO:0031016|pancreas development;GO:0032355|response to estradiol;GO:0032967|positive regulation of collagen biosynthetic process;GO:0033085|negative regulation of T cell differentiation in thymus;GO:0033088|negative regulation of immature T cell proliferation in thymus;GO:0033089|positive regulation of T cell differentiation in thymus;GO:0035264|multicellular organism growth;GO:0035988|chondrocyte proliferation;GO:0040008|regulation of growth;GO:0042733|embryonic digit morphogenesis;GO:0043010|camera-type eye development;GO:0043066|negative regulation of apoptotic process;GO:0045453|bone resorption;GO:0045596|negative regulation of cell differentiation;GO:0045880|positive regulation of smoothened signaling pathway;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046638|positive regulation of alpha-beta T cell differentiation;GO:0046639|negative regulation of alpha-beta T cell differentiation;GO:0048074|negative regulation of eye pigmentation;GO:0048469|cell maturation;GO:0048557|embryonic digestive tract morphogenesis;GO:0048596|embryonic camera-type eye morphogenesis;GO:0048666|neuron development;GO:0048745|smooth muscle tissue development;GO:0050679|positive regulation of epithelial cell proliferation;GO:0051216|cartilage development;GO:0060135|maternal process involved in female pregnancy;GO:0060220|camera-type eye photoreceptor cell fate commitment;GO:0060323|head morphogenesis;GO:0061053|somite development;GO:0072498|embryonic skeletal joint development;GO:0090136|epithelial cell-cell adhesion;GO:0097421|liver regeneration;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0031012|extracellular matrix;","GO:0003674|molecular_function;GO:0005113|patched binding;GO:0005509|calcium ion binding;GO:0008233|peptidase activity;","K11989","IHH; indian hedgehog"]
["ENSRNOG00000001442",1188,99.95269915,3640,234.162795,0.426851324,-1.22819444,{"v":2.1276e-167,"d":"2.13E-167"},{"v":6.2619E-166,"d":"6.26E-166"},"down","yes","Por","protein_coding","chr12:20951058-20999245:-","gi|13928780|ref|NP_113764.1|",3576,0,"NADPH--cytochrome P450 reductase [Rattus norvegicus]","gi|13928779|ref|NM_031576.1|",2428,0,"Rattus norvegicus P450 (cytochrome) oxidoreductase (Por), mRNA","P00388",1382,0,"NADPH--cytochrome P450 reductase","SPBC365.17",347,{"v":3e-106,"d":"3.00E-106"},"COG0369","pfam00667","FAD_binding_1","FAD binding domain. This domain is found in sulfite reductase, NADPH cytochrome P450 reductase, Nitric oxide synthase and methionine synthase reductase.","GO:0003420|regulation of growth plate cartilage chondrocyte proliferation;GO:0007584|response to nutrient;GO:0009410|response to xenobiotic stimulus;GO:0009437|carnitine metabolic process;GO:0009725|response to hormone;GO:0009812|flavonoid metabolic process;GO:0018393|internal peptidyl-lysine acetylation;GO:0019395|fatty acid oxidation;GO:0022900|electron transport chain;GO:0032332|positive regulation of chondrocyte differentiation;GO:0032770|positive regulation of monooxygenase activity;GO:0043066|negative regulation of apoptotic process;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043602|nitrate catabolic process;GO:0045542|positive regulation of cholesterol biosynthetic process;GO:0045880|positive regulation of smoothened signaling pathway;GO:0046210|nitric oxide catabolic process;GO:0060192|negative regulation of lipase activity;GO:0070988|demethylation;GO:0071371|cellular response to gonadotropin stimulus;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0071375|cellular response to peptide hormone stimulus;GO:0071548|response to dexamethasone;GO:0090031|positive regulation of steroid hormone biosynthetic process;GO:0090181|regulation of cholesterol metabolic process;GO:0090346|cellular organofluorine metabolic process;","GO:0005739|mitochondrion;GO:0005789|endoplasmic reticulum membrane;GO:0005829|cytosol;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0003958|NADPH-hemoprotein reductase activity;GO:0004128|cytochrome-b5 reductase activity, acting on NAD(P)H;GO:0008941|nitric oxide dioxygenase activity;GO:0009055|electron transfer activity;GO:0010181|FMN binding;GO:0016491|oxidoreductase activity;GO:0016787|hydrolase activity;GO:0019899|enzyme binding;GO:0047726|iron-cytochrome-c reductase activity;GO:0050660|flavin adenine dinucleotide binding;GO:0050661|NADP binding;","K00327","POR; NADPH-ferrihemoprotein reductase [EC:1.6.2.4]"]
["ENSRNOG00000009884",984,82.78910435,3218,207.0153501,0.399917708,-1.322224931,{"v":4.9367e-166,"d":"4.94E-166"},{"v":1.4222E-164,"d":"1.42E-164"},"down","yes","Lgals1","protein_coding","chr7:110481392-110488345:+","gi|9845261|ref|NP_063969.1|",702,{"v":6e-91,"d":"6.00E-91"},"galectin-1 [Rattus norvegicus]","gi|298906512|emb|FQ222079.1|",461,0,"Rattus norvegicus TL0ADA29YF14 mRNA sequence","P11762",275,{"v":2E-92,"d":"2.00E-92"},"Galectin-1",".",".",".",".","pfam00337","Gal-bind_lectin","Galactoside-binding lectin. This family contains galactoside binding lectins.   The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).","GO:0002317|plasma cell differentiation;GO:0006915|apoptotic process;GO:0009410|response to xenobiotic stimulus;GO:0010812|negative regulation of cell-substrate adhesion;GO:0010977|negative regulation of neuron projection development;GO:0031295|T cell costimulation;GO:0034120|positive regulation of erythrocyte aggregation;GO:0035900|response to isolation stress;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045445|myoblast differentiation;GO:0046598|positive regulation of viral entry into host cell;GO:0048678|response to axon injury;GO:0071333|cellular response to glucose stimulus;GO:0071407|cellular response to organic cyclic compound;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0009986|cell surface;","GO:0005515|protein binding;GO:0030246|carbohydrate binding;GO:0030395|lactose binding;GO:0042802|identical protein binding;GO:0043236|laminin binding;","K06830","LGALS1; galectin-1"]
["ENSRNOG00000018796",1814,152.6213773,4828,310.5873556,0.491395978,-1.025042046,{"v":5.7623e-166,"d":"5.76E-166"},{"v":1.6513e-164,"d":"1.65E-164"},"down","yes","Herpud1","protein_coding","chr19:10598417-10618424:-","gi|564394581|ref|XP_006255195.1|",2116,0,"PREDICTED: homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein isoform X1 [Rattus norvegicus]","gi|672084209|ref|XM_006255133.2|",2147,0,"PREDICTED: Rattus norvegicus homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 (Herpud1), transcript variant X1, mRNA","Q9JJK5",633,0,"Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein",".",".",".",".","pfam00240","ubiquitin","Ubiquitin family. This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) Nedd8, Elongin B, Rub1, and Parkin. A number of them are thought to carry a distinctive five-residue motif termed the proteasome-interacting motif (PIM), which may have a biologically significant role in protein delivery to proteasomes and recruitment of proteasomes to transcription sites.","GO:0006511|ubiquitin-dependent protein catabolic process;GO:0006874|cellular calcium ion homeostasis;GO:0006986|response to unfolded protein;GO:0016567|protein ubiquitination;GO:0030433|ubiquitin-dependent ERAD pathway;GO:0030968|endoplasmic reticulum unfolded protein response;GO:0030970|retrograde protein transport, ER to cytosol;GO:0031396|regulation of protein ubiquitination;GO:0032469|endoplasmic reticulum calcium ion homeostasis;GO:0034976|response to endoplasmic reticulum stress;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045047|protein targeting to ER;GO:1902235|regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:1902236|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:1903069|regulation of ER-associated ubiquitin-dependent protein catabolic process;GO:1903071|positive regulation of ER-associated ubiquitin-dependent protein catabolic process;GO:2001243|negative regulation of intrinsic apoptotic signaling pathway;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0044322|endoplasmic reticulum quality control compartment;GO:1990037|Lewy body core;","GO:0044325|ion channel binding;GO:1990756|protein binding, bridging involved in substrate recognition for ubiquitination;","K14027","HERPUD1, HERP; homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein"]
["ENSRNOG00000014456",1342,112.9095305,3918,252.0466568,0.447970753,-1.158523551,{"v":2.7931e-164,"d":"2.79E-164"},{"v":7.9624e-163,"d":"7.96E-163"},"down","yes","Coq10b","protein_coding","chr9:56553758-56573663:+","gi|57528275|ref|NP_001009671.1|",1086,{"v":6e-143,"d":"6.00E-143"},"coenzyme Q-binding protein COQ10 homolog B, mitochondrial [Rattus norvegicus]","gi|57528274|ref|NM_001009671.1|",1600,0,"Rattus norvegicus coenzyme Q10B (Coq10b), mRNA","Q5I0I9",422,{"v":3e-144,"d":"3.00E-144"},"Coenzyme Q-binding protein COQ10 homolog B, mitochondrial","RSc1425",75.9,{"v":4e-15,"d":"4.00E-15"},"COG2867","pfam03364","Polyketide_cyc","Polyketide cyclase / dehydrase and lipid transport. This family contains polyketide cylcases/dehydrases which are enzymes involved in polyketide synthesis. The family also includes proteins which are involved in the binding/transport of lipids.","GO:0006744|ubiquinone biosynthetic process;GO:0045333|cellular respiration;","GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;","GO:0048039|ubiquinone binding;","K18588","COQ10; coenzyme Q-binding protein COQ10"]
["ENSRNOG00000070875",378,31.80313155,1854,119.2686324,0.266651264,-1.90697393,{"v":1.6592E-162,"d":"1.66E-162"},{"v":4.6807e-161,"d":"4.68E-161"},"down","yes","Nat8f4","protein_coding","chr4:118325874-118332658:-","gi|564303978|ref|XP_006225040.1|",1128,{"v":3e-138,"d":"3.00E-138"},"PREDICTED: probable N-acetyltransferase CML2 [Rattus norvegicus]","gi|672050329|ref|XM_008763098.1|",5328,0,"PREDICTED: Rattus norvegicus probable N-acetyltransferase CML2-like (LOC102556148), transcript variant X1, mRNA","P85118",399,{"v":2E-125,"d":"2.00E-125"},"N-acetyltransferase family 8 member 2",".",".",".",".","pfam00583","Acetyltransf_1","Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.",".",".",".",".","."]
["ENSRNOG00000066042",934,78.58234092,3073,197.6874365,0.397508017,-1.330944137,{"v":3.092E-160,"d":"3.09E-160"},{"v":8.6336e-159,"d":"8.63E-159"},"down","yes","Abcb1b","protein_coding","chr4:25242798-25325199:-","gi|672048806|ref|XP_008760909.1|",6037,0,"PREDICTED: multidrug resistance protein 1 isoform X1 [Rattus norvegicus]","gi|25453369|ref|NM_012623.2|",3658,0,"Rattus norvegicus ATP-binding cassette, subfamily B (MDR/TAP), member 1B (Abcb1b), mRNA","P43245",2265,0,"Multidrug resistance protein 1","SPCC663.03",461,{"v":6e-136,"d":"6.00E-136"},"COG1132","pfam00664","ABC_membrane","ABC transporter transmembrane region. This family represents a unit of six transmembrane helices. Many members of the ABC transporter family (pfam00005) have two such regions.",".",".",".",".","."]
["ENSRNOG00000010389",1393,117.2004292,3963,254.9415265,0.459714943,-1.121188535,{"v":9.7022E-158,"d":"9.70E-158"},{"v":2.6546E-156,"d":"2.65E-156"},"down","yes","Ndrg2","protein_coding","chr15:24600982-24609626:-","gi|354505215|ref|XP_003514667.1|",1751,0,"PREDICTED: protein NDRG2 isoform X1 [Cricetulus griseus]","gi|399498532|ref|NM_001270863.1|",1960,0,"Rattus norvegicus NDRG family member 2 (Ndrg2), transcript variant 3, mRNA","Q9QYG0",672,0,"Protein NDRG2",".",".",".",".","pfam03096","Ndr","Ndr family. This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, and Ndr3. Their similarity was previously noted. The precise molecular and cellular function of members of this family is still unknown. Yet, they are known to be involved in cellular differentiation events. The Ndr1 group was the first to be discovered. Their expression is repressed by the proto-oncogenes N-myc and c-myc, and in line with this observation, Ndr1 protein expression is down-regulated in neoplastic cells, and is reactivated when differentiation is induced by chemicals such as retinoic acid. Ndr2 and Ndr3 expression is not under the control of N-myc or c-myc. Ndr1 expression is also activated by several chemicals: tunicamycin and homocysteine induce Ndr1 in human umbilical endothelial cells; nickel induces Ndr1 in several cell types. Members of this family are found in wide variety of multicellular eukaryotes, including an Ndr1 type protein in Helianthus annuus (sunflower), known as Sf21. Interestingly, the highest scoring matches in the noise are all alpha/beta hydrolases pfam00561, suggesting that this family may have an enzymatic function (Bateman A pers. obs.).","GO:0001818|negative regulation of cytokine production;GO:0007165|signal transduction;GO:0007399|nervous system development;GO:0010574|regulation of vascular endothelial growth factor production;GO:0016055|Wnt signaling pathway;GO:0021762|substantia nigra development;GO:0030154|cell differentiation;GO:0048662|negative regulation of smooth muscle cell proliferation;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0090361|regulation of platelet-derived growth factor production;GO:0099173|postsynapse organization;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0030426|growth cone;GO:0048471|perinuclear region of cytoplasm;GO:0098978|glutamatergic synapse;",".",".","."]
["ENSRNOG00000017163",1690,142.188604,4516,290.5162588,0.489434239,-1.030813065,{"v":8.6023e-157,"d":"8.60E-157"},{"v":2.3303e-155,"d":"2.33E-155"},"down","yes","Pfkp","protein_coding","chr17:63729780-63794018:+","gi|57977273|ref|NP_996729.1|",3799,0,"ATP-dependent 6-phosphofructokinase, platelet type [Rattus norvegicus]","gi|672082475|ref|XM_008771885.1|",2510,0,"PREDICTED: Rattus norvegicus phosphofructokinase, platelet (Pfkp), transcript variant X1, mRNA","P47860",1467,0,"ATP-dependent 6-phosphofructokinase, platelet type","SPBC16H5.02",595,0,"COG0205","pfam00365","PFK","Phosphofructokinase.","GO:0006002|fructose 6-phosphate metabolic process;GO:0006096|glycolytic process;GO:0030388|fructose 1,6-bisphosphate metabolic process;GO:0061615|glycolytic process through fructose-6-phosphate;GO:0061621|canonical glycolysis;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005945|6-phosphofructokinase complex;GO:0016020|membrane;","GO:0003872|6-phosphofructokinase activity;GO:0005524|ATP binding;GO:0016208|AMP binding;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;GO:0046872|metal ion binding;GO:0048029|monosaccharide binding;GO:0070095|fructose-6-phosphate binding;","K00850","pfkA, PFK; 6-phosphofructokinase 1 [EC:2.7.1.11]"]
["ENSRNOG00000011861",274,23.05306361,1536,98.81155305,0.233303322,-2.099721243,{"v":8.4721e-153,"d":"8.47E-153"},{"v":2.2393E-151,"d":"2.24E-151"},"down","yes","Aadat","protein_coding","chr16:29509394-29544332:-","gi|8393641|ref|NP_058889.1|",2022,0,"kynurenine/alpha-aminoadipate aminotransferase, mitochondrial [Rattus norvegicus]","gi|672080048|ref|XM_006253067.2|",1326,0,"PREDICTED: Rattus norvegicus aminoadipate aminotransferase (Aadat), transcript variant X1, mRNA","Q64602",783,0,"Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial","SPCC569.07",225,{"v":2e-65,"d":"2.00E-65"},"COG1167","pfam00155","Aminotran_1_2","Aminotransferase class I and II.","GO:0006103|2-oxoglutarate metabolic process;GO:0006536|glutamate metabolic process;GO:0009058|biosynthetic process;GO:0033512|L-lysine catabolic process to acetyl-CoA via saccharopine;GO:0070189|kynurenine metabolic process;GO:0097052|L-kynurenine metabolic process;GO:1901605|alpha-amino acid metabolic process;","GO:0005739|mitochondrion;","GO:0003824|catalytic activity;GO:0008483|transaminase activity;GO:0016212|kynurenine-oxoglutarate transaminase activity;GO:0030170|pyridoxal phosphate binding;GO:0042803|protein homodimerization activity;GO:0047536|2-aminoadipate transaminase activity;","K00825","AADAT, KAT2; kynurenine/2-aminoadipate aminotransferase [EC:2.6.1.7 2.6.1.39]"]
["ENSRNOG00000017283",1468,123.5105744,4049,260.4739442,0.474176313,-1.0765045,{"v":5.5709e-151,"d":"5.57E-151"},{"v":1.4513E-149,"d":"1.45E-149"},"down","yes","Kcnt1","protein_coding","chr3:8682113-8736667:+","gi|564339775|ref|XP_006233769.1|",6032,0,"PREDICTED: potassium channel subfamily T member 1 isoform X11 [Rattus norvegicus]","gi|672044814|ref|XM_006233707.2|",4683,0,"PREDICTED: Rattus norvegicus potassium channel, subfamily T, member 1 (Kcnt1), transcript variant X11, mRNA","Q9Z258",2244,0,"Potassium channel subfamily T member 1",".",".",".",".","pfam03493","BK_channel_a","Calcium-activated BK potassium channel alpha subunit.","GO:0006813|potassium ion transport;GO:0071805|potassium ion transmembrane transport;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0005228|intracellular sodium activated potassium channel activity;GO:0005267|potassium channel activity;GO:0015271|outward rectifier potassium channel activity;","K04946","KCNT1, KNA1.1; potassium channel subfamily T member 1"]
["ENSRNOG00000002270",1679,141.2631161,4439,285.5628151,0.494683161,-1.015423304,{"v":1.962E-150,"d":"1.96E-150"},{"v":5.0629e-149,"d":"5.06E-149"},"down","yes","Hnrnpdl","protein_coding","chr14:9557425-9562506:+","gi|564382848|ref|XP_006250724.1|",1435,0,"PREDICTED: heterogeneous nuclear ribonucleoprotein D-like isoform X1 [Rattus norvegicus]","gi|755512667|ref|XR_389283.2|",1701,0,"PREDICTED: Mus musculus heterogeneous nuclear ribonucleoprotein D-like (Hnrnpdl), transcript variant X4, misc_RNA","O14979",501,{"v":3e-169,"d":"3.00E-169"},"Heterogeneous nuclear ribonucleoprotein D-like",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0010468|regulation of gene expression;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;","GO:0003677|DNA binding;GO:0003690|double-stranded DNA binding;GO:0003697|single-stranded DNA binding;GO:0003723|RNA binding;GO:0008143|poly(A) binding;GO:0034046|poly(G) binding;","K13044","HNRNPABD; heterogeneous nuclear ribonucleoprotein A/B/D"]
["ENSRNOG00000064007",1072,90.19300799,3264,209.9745502,0.42954257,-1.219126977,{"v":1.3586E-148,"d":"1.36E-148"},{"v":3.4894e-147,"d":"3.49E-147"},"down","yes","ENSRNOG00000064007","protein_coding","chrX:40582255-40585197:-","gi|947316624|ref|XP_014448704.1|",568,{"v":5e-88,"d":"5.00E-88"},"PREDICTED: endogenous retrovirus group K member 18 Pol protein-like [Tupaia chinensis]","gi|153791782|ref|NG_006339.2|",1123,0,"Rattus norvegicus vomeronasal 2 receptor, pseudogene 55 (Vom2r-ps55) on chromosome 1","P04026",210,{"v":2e-81,"d":"2.00E-81"},"Intracisternal A-particle Pol-related polyprotein (Fragment)",".",".",".",".","pfam00665","rve","Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyses the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.",".",".",".",".","."]
["ENSRNOG00000001295",909,76.4789592,2924,188.1022013,0.406581947,-1.298381937,{"v":6.4821e-147,"d":"6.48E-147"},{"v":1.657e-145,"d":"1.66E-145"},"down","yes","S100b","protein_coding","chr20:12372881-12394743:-","gi|149043704|gb|EDL97155.1|",313,{"v":3e-36,"d":"3.00E-36"},"S100 protein, beta polypeptide, isoform CRA_a [Rattus norvegicus]","gi|672086144|ref|XM_008772868.1|",1484,0,"PREDICTED: Rattus norvegicus S100 calcium binding protein B (S100b), transcript variant X1, mRNA","P04631",139,{"v":1e-37,"d":"1.00E-37"},"Protein S100-B",".",".",".",".","pfam01023","S_100","S-100/ICaBP type calcium binding domain. The S-100 domain is a subfamily of the EF-hand calcium binding proteins.","GO:0007611|learning or memory;GO:0007613|memory;GO:0008284|positive regulation of cell proliferation;GO:0008360|regulation of cell shape;GO:0031643|positive regulation of myelination;GO:0043065|positive regulation of apoptotic process;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0048168|regulation of neuronal synaptic plasticity;GO:0048708|astrocyte differentiation;GO:0050806|positive regulation of synaptic transmission;GO:0051384|response to glucocorticoid;GO:0051597|response to methylmercury;GO:0060291|long-term synaptic potentiation;GO:0071456|cellular response to hypoxia;GO:2001015|negative regulation of skeletal muscle cell differentiation;","GO:0001726|ruffle;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0043025|neuronal cell body;GO:0043231|intracellular membrane-bounded organelle;GO:0048471|perinuclear region of cytoplasm;","GO:0005102|signaling receptor binding;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0008270|zinc ion binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0044548|S100 protein binding;GO:0048156|tau protein binding;GO:0048306|calcium-dependent protein binding;GO:0050786|RAGE receptor binding;","K23770","S100B; protein S100-B"]
["ENSRNOG00000019556",1490,125.3615503,4039,259.8306398,0.482474085,-1.051476641,{"v":5.1001e-145,"d":"5.10E-145"},{"v":1.2916E-143,"d":"1.29E-143"},"down","yes","Cd9","protein_coding","chr4:158256328-158289222:-","gi|148229054|ref|NP_444177.1|",881,{"v":3e-109,"d":"3.00E-109"},"CD9 antigen [Rattus norvegicus]","gi|298885141|emb|FQ230141.1|",675,0,"Rattus norvegicus TL0ADA45YH23 mRNA sequence","P40241",343,{"v":1e-110,"d":"1.00E-110"},"CD9 antigen",".",".",".",".","pfam00335","Tetraspannin","Tetraspanin family.","GO:0007155|cell adhesion;GO:0007338|single fertilization;GO:0007342|fusion of sperm to egg plasma membrane involved in single fertilization;GO:0007420|brain development;GO:0008285|negative regulation of cell proliferation;GO:0008347|glial cell migration;GO:0009414|response to water deprivation;GO:0014003|oligodendrocyte development;GO:0014905|myoblast fusion involved in skeletal muscle regeneration;GO:0030913|paranodal junction assembly;GO:0031623|receptor internalization;GO:0035036|sperm-egg recognition;GO:0051271|negative regulation of cellular component movement;GO:0071404|cellular response to low-density lipoprotein particle stimulus;GO:0090331|negative regulation of platelet aggregation;GO:1905521|regulation of macrophage migration;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0016324|apical plasma membrane;GO:0032991|protein-containing complex;GO:0070062|extracellular exosome;","GO:0005178|integrin binding;GO:0005515|protein binding;","K06460","CD9, TSPAN29; CD9 antigen"]
["ENSRNOG00000000800",901,75.80587705,2893,186.1079577,0.407322062,-1.295758137,{"v":6.2659E-145,"d":"6.27E-145"},{"v":1.5795e-143,"d":"1.58E-143"},"down","yes","Man1a1","protein_coding","chr20:33202517-33385824:-","gi|564398053|ref|XP_006256559.1|",3676,0,"PREDICTED: mannosyl-oligosaccharide 1,2-alpha-mannosidase IA isoform X1 [Rattus norvegicus]","gi|75905482|ref|NM_001033656.1|",3857,0,"Rattus norvegicus mannosidase, alpha, class 1A, member 1 (Man1a1), mRNA","P45700",1238,0,"Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA",".",".",".",".","pfam01532","Glyco_hydro_47","Glycosyl hydrolase family 47. Members of this family are alpha-mannosidases that catalyse the hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2).","GO:0005975|carbohydrate metabolic process;GO:0006491|N-glycan processing;GO:0030433|ubiquitin-dependent ERAD pathway;GO:0045047|protein targeting to ER;GO:1904382|mannose trimming involved in glycoprotein ERAD pathway;","GO:0000139|Golgi membrane;GO:0005783|endoplasmic reticulum;GO:0005793|endoplasmic reticulum-Golgi intermediate compartment;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0016021|integral component of membrane;GO:0031410|cytoplasmic vesicle;","GO:0004571|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity;GO:0005509|calcium ion binding;","K01230","MAN1A_C, MNS1_2; mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113]"]
["ENSRNOG00000016414",1110,93.3901482,3285,211.3254894,0.441925621,-1.178124519,{"v":9.4198e-142,"d":"9.42E-142"},{"v":2.2795E-140,"d":"2.28E-140"},"down","yes","Slc22a17","protein_coding","chr15:28382292-28388799:-","gi|803249319|ref|XP_011984643.1|",2155,0,"PREDICTED: solute carrier family 22 member 17 isoform X2 [Ovis aries musimon]","gi|564386150|ref|XM_006251965.1|",2350,0,"PREDICTED: Rattus norvegicus solute carrier family 22, member 17 (Slc22a17), transcript variant X1, mRNA","Q3SZQ2",788,0,"Solute carrier family 22 member 17",".",".",".",".","pfam07690","MFS_1","Major Facilitator Superfamily.","GO:0015891|siderophore transport;GO:0055072|iron ion homeostasis;GO:0055085|transmembrane transport;","GO:0005774|vacuolar membrane;GO:0005887|integral component of plasma membrane;GO:0031301|integral component of organelle membrane;","GO:0004888|transmembrane signaling receptor activity;GO:0022857|transmembrane transporter activity;","K08213","SLC22A17; MFS transporter, OCT family, solute carrier family 22 (organic cation transporter), member 17"]
["ENSRNOG00000029535",1395,117.3686998,3806,244.8416477,0.479365749,-1.060801265,{"v":1.0014e-138,"d":"1.00E-138"},{"v":2.3706e-137,"d":"2.37E-137"},"down","yes","Nrbp2","protein_coding","chr7:107799497-107805230:-","gi|564360701|ref|XP_006241947.1|",2528,0,"PREDICTED: nuclear receptor-binding protein 2 isoform X1 [Rattus norvegicus]","gi|672059557|ref|XM_006241885.2|",2647,0,"PREDICTED: Rattus norvegicus nuclear receptor binding protein 2 (Nrbp2), transcript variant X1, mRNA","Q91V36",976,0,"Nuclear receptor-binding protein 2",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006468|protein phosphorylation;GO:0006888|ER to Golgi vesicle-mediated transport;GO:0016242|negative regulation of macroautophagy;GO:0030182|neuron differentiation;GO:0035556|intracellular signal transduction;GO:0043524|negative regulation of neuron apoptotic process;","GO:0005737|cytoplasm;GO:0012505|endomembrane system;","GO:0003674|molecular_function;GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;","K08875","NRBP; nuclear receptor-binding protein"]
["ENSRNOG00000009358",448,37.69260035,1878,120.8125629,0.311992391,-1.680417251,{"v":1.4519e-138,"d":"1.45E-138"},{"v":3.4223e-137,"d":"3.42E-137"},"down","yes","Osgin2","protein_coding","chr5:29500408-29520831:-","gi|293347270|ref|XP_001056612.2|",2872,0,"PREDICTED: oxidative stress-induced growth inhibitor 2 isoform X1 [Rattus norvegicus]","gi|672019168|ref|XM_001056612.5|",2363,0,"PREDICTED: Rattus norvegicus oxidative stress induced growth inhibitor family member 2 (Osgin2), transcript variant X1, mRNA","Q9Y236",949,0,"Oxidative stress-induced growth inhibitor 2",".",".",".",".","pfam13738","Pyr_redox_3","Pyridine nucleotide-disulphide oxidoreductase.","GO:0007165|signal transduction;GO:0030308|negative regulation of cell growth;",".","GO:0008083|growth factor activity;",".","."]
["ENSRNOG00000067835",246,20.69727609,1374,88.39002207,0.234158513,-2.094442609,{"v":1.8324e-136,"d":"1.83E-136"},{"v":4.2456E-135,"d":"4.25E-135"},"down","yes","ENSRNOG00000067835","lncRNA","chr12:35662951-35668551:+","gi|149027698|gb|EDL83221.1|",199,{"v":3e-15,"d":"3.00E-15"},"rCG29124 [Rattus norvegicus]","gi|241982901|gb|AC136178.3|",611,0,"Rattus norvegicus CH230-435P16 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam00429","TLV_coat","ENV polyprotein (coat polyprotein).",".",".",".",".","."]
["ENSRNOG00000027433",247,20.78141136,1375,88.4543525,0.234939387,-2.089639497,{"v":3.6178e-136,"d":"3.62E-136"},{"v":8.3467e-135,"d":"8.35E-135"},"down","yes","Akr1b8","protein_coding","chr4:62997161-63010097:+","gi|149065228|gb|EDM15304.1|",1536,0,"rCG27994 [Rattus norvegicus]","gi|51480423|gb|BC080239.1|",2994,0,"Rattus norvegicus aldo-keto reductase family 1, member B8, mRNA (cDNA clone IMAGE:7100613), with apparent retained intron","P45377",567,0,"Aldose reductase-related protein 2","slr0942",223,{"v":4e-64,"d":"4.00E-64"},"COG0656","pfam00248","Aldo_ket_red","Aldo/keto reductase family. This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.",".",".",".",".","."]
["ENSRNOG00000012153",912,76.73136501,2843,182.8914358,0.419545971,-1.253099195,{"v":2.5481E-135,"d":"2.55E-135"},{"v":5.8541e-134,"d":"5.85E-134"},"down","yes","Rbl2","protein_coding","chr19:15876853-15923572:-","gi|564394744|ref|XP_006255261.1|",5415,0,"PREDICTED: retinoblastoma-like protein 2 isoform X1 [Rattus norvegicus]","gi|672084204|ref|XM_006255199.2|",4863,0,"PREDICTED: Rattus norvegicus retinoblastoma-like 2 (Rbl2), transcript variant X1, mRNA","O55081",2081,0,"Retinoblastoma-like protein 2",".",".",".",".","pfam01858","RB_A","Retinoblastoma-associated protein A domain. This domain has the cyclin fold as predicted.","GO:0006325|chromatin organization;GO:0006357|regulation of transcription by RNA polymerase II;GO:0010629|negative regulation of gene expression;GO:0030154|cell differentiation;GO:0043550|regulation of lipid kinase activity;GO:0051302|regulation of cell division;GO:0051726|regulation of cell cycle;GO:2000134|negative regulation of G1/S transition of mitotic cell cycle;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005694|chromosome;GO:0005730|nucleolus;GO:0005829|cytosol;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0005515|protein binding;GO:1990841|promoter-specific chromatin binding;","K16332","RBL2; retinoblastoma-like protein 2"]
["ENSRNOG00000010311",1080,90.86609014,3171,203.9918195,0.445439873,-1.16669739,{"v":8.0056e-135,"d":"8.01E-135"},{"v":1.8315e-133,"d":"1.83E-133"},"down","yes","Dzip1","protein_coding","chr15:95956398-96010066:-","gi|564318360|ref|XP_006222121.1|",4035,0,"PREDICTED: zinc finger protein DZIP1 isoform X3 [Rattus norvegicus]","gi|672028922|ref|XM_006222059.2|",3502,0,"PREDICTED: Rattus norvegicus DAZ interacting zinc finger protein 1 (Dzip1), transcript variant X3, mRNA","Q8BMD2",1359,0,"Zinc finger protein DZIP1",".",".",".",".","pfam13815","Dzip-like_N","Iguana/Dzip1-like DAZ-interacting protein N-terminal. The DAZ gene-product - Deleted in Azoospermia - and a closely related sequence are required early in germ-cell development in order to maintain germ-cell populations. This family is the N-terminal region that is the only part of the protein in some fungi and lower metazoa.","GO:0007224|smoothened signaling pathway;GO:0007281|germ cell development;GO:0007283|spermatogenesis;GO:0033365|protein localization to organelle;GO:0043393|regulation of protein binding;GO:0044782|cilium organization;GO:0045184|establishment of protein localization;GO:0045724|positive regulation of cilium assembly;GO:0051220|cytoplasmic sequestering of protein;GO:0060271|cilium assembly;GO:0061512|protein localization to cilium;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0005814|centriole;GO:0005829|cytosol;GO:0034451|centriolar satellite;GO:0036064|ciliary basal body;GO:0097539|ciliary transition fiber;",".","K16470","DZIP1; zinc finger protein DZIP1"]
["ENSRNOG00000027847",1101,92.63293078,3198,205.7287413,0.450267329,-1.151146295,{"v":4.1177e-133,"d":"4.12E-133"},{"v":9.2645e-132,"d":"9.26E-132"},"down","yes","Nxpe2","protein_coding","chr8:48661708-48698035:-","gi|149041573|gb|EDL95414.1|",2880,0,"rCG58102, isoform CRA_b [Rattus norvegicus]","gi|672022774|ref|XM_003754424.3|",3044,0,"PREDICTED: Rattus norvegicus neurexophilin and PC-esterase domain family, member 2 (Nxpe2), transcript variant X1, mRNA","Q3U095",961,0,"NXPE family member 2",".",".",".",".","pfam06312","Neurexophilin","Neurexophilin. This family consists of mammalian neurexophilin proteins. Mammalian brains contain four different neurexophilin proteins. Neurexophilins form a family of related glycoproteins that are proteolytically processed after synthesis and bind to alpha-neurexins. The structure and characteristics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000058436",15,1.26202903,617,39.69188036,0.031795647,-4.975026909,{"v":1.5495e-127,"d":"1.55E-127"},{"v":3.2956e-126,"d":"3.30E-126"},"down","yes","ENSRNOG00000058436","protein_coding","chr1:61427039-61448888:+","gi|564296543|ref|XP_006223014.1|",4101,0,"PREDICTED: zinc finger protein 52 isoform X1 [Rattus norvegicus]","gi|672034453|ref|XM_008758764.1|",2537,0,"PREDICTED: Rattus norvegicus zinc finger protein 52 (Zfp52), transcript variant X5, mRNA","Q8TAQ5",660,0,"Zinc finger protein 420",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0045944|positive regulation of transcription by RNA polymerase II;",".","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0046872|metal ion binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSRNOG00000001525",1182,99.44788754,3302,212.4191069,0.468168278,-1.09490091,{"v":7.0034e-127,"d":"7.00E-127"},{"v":1.478e-125,"d":"1.48E-125"},"down","yes","Igsf11","protein_coding","chr11:61733144-61868348:-","gi|61557018|ref|NP_001013138.1|",1840,0,"immunoglobulin superfamily member 11 precursor [Rattus norvegicus]","gi|61557017|ref|NM_001013120.1|",3616,0,"Rattus norvegicus immunoglobulin superfamily, member 11 (Igsf11), mRNA","Q5U2P2",713,0,"Immunoglobulin superfamily member 11",".",".",".",".","pfam13927","Ig_3","Immunoglobulin domain. This family contains immunoglobulin-like domains.","GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0040008|regulation of growth;GO:0045185|maintenance of protein location;GO:0048167|regulation of synaptic plasticity;GO:0061885|positive regulation of mini excitatory postsynaptic potential;GO:1900273|positive regulation of long-term synaptic potentiation;","GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0014069|postsynaptic density;GO:0016021|integral component of membrane;GO:0060076|excitatory synapse;","GO:0005515|protein binding;GO:0035255|ionotropic glutamate receptor binding;","K06791","IGSF11; immunoglobulin superfamily, member 11"]
["ENSRNOG00000004303",947,79.67609941,2847,183.1487575,0.435034889,-1.200796988,{"v":7.7328E-127,"d":"7.73E-127"},{"v":1.6256E-125,"d":"1.63E-125"},"down","yes","Timp3","protein_coding","chr7:17521919-17571839:-","gi|67972654|ref|NP_037018.2|",1030,{"v":2e-134,"d":"2.00E-134"},"metalloproteinase inhibitor 3 precursor [Rattus norvegicus]","gi|67972653|ref|NM_012886.2|",1743,0,"Rattus norvegicus TIMP metallopeptidase inhibitor 3 (Timp3), mRNA","P39876",400,{"v":3e-135,"d":"3.00E-135"},"Metalloproteinase inhibitor 3",".",".",".",".","pfam00965","TIMP","Tissue inhibitor of metalloproteinase. Members of this family are common in extracellular regions of vertebrate species","GO:0007417|central nervous system development;GO:0007568|aging;GO:0009612|response to mechanical stimulus;GO:0009725|response to hormone;GO:0010033|response to organic substance;GO:0010951|negative regulation of endopeptidase activity;GO:0014070|response to organic cyclic compound;GO:0034097|response to cytokine;GO:0042246|tissue regeneration;GO:0043200|response to amino acid;GO:0043627|response to estrogen;GO:0045861|negative regulation of proteolysis;GO:0051045|negative regulation of membrane protein ectodomain proteolysis;GO:0051593|response to folic acid;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0071310|cellular response to organic substance;GO:1903984|positive regulation of TRAIL-activated apoptotic signaling pathway;GO:1904684|negative regulation of metalloendopeptidase activity;","GO:0005576|extracellular region;GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0031012|extracellular matrix;","GO:0002020|protease binding;GO:0003674|molecular_function;GO:0008191|metalloendopeptidase inhibitor activity;GO:0008270|zinc ion binding;GO:0046872|metal ion binding;","K16866","TIMP3; metalloproteinase inhibitor 3"]
["ENSRNOG00000019651",1222,102.8132983,3376,217.1795593,0.473402279,-1.078861444,{"v":1.171E-126,"d":"1.17E-126"},{"v":2.4428e-125,"d":"2.44E-125"},"down","yes","Slc12a4","protein_coding","chr19:33838419-33860331:-","gi|9507107|ref|NP_062102.1|",5203,0,"solute carrier family 12 member 4 [Rattus norvegicus]","gi|451958135|ref|NM_019229.2|",3718,0,"Rattus norvegicus solute carrier family 12 (potassium/chloride transporter), member 4 (Slc12a4), mRNA","Q63632",2008,0,"Solute carrier family 12 member 4","SPBC18H10.16",157,{"v":6e-38,"d":"6.00E-38"},"COG0531","pfam00324","AA_permease","Amino acid permease.","GO:0006884|cell volume homeostasis;GO:0007268|chemical synaptic transmission;GO:0055064|chloride ion homeostasis;GO:0055075|potassium ion homeostasis;GO:1902476|chloride transmembrane transport;GO:1990573|potassium ion import across plasma membrane;","GO:0016021|integral component of membrane;GO:0045202|synapse;","GO:0015379|potassium:chloride symporter activity;GO:0019901|protein kinase binding;","K14427","SLC12A4_6, KCC1_3; solute carrier family 12 (potassium/chloride transporter), member 4/6"]
["ENSRNOG00000003232",754,63.43799256,2443,157.1592605,0.403654181,-1.30880826,{"v":1.3927E-124,"d":"1.39E-124"},{"v":2.7982e-123,"d":"2.80E-123"},"down","yes","Slc9a3r1","protein_coding","chr10:100403069-100420598:+","gi|11024674|ref|NP_067605.1|",1686,0,"Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [Rattus norvegicus]","gi|298903780|emb|FQ213792.1|",1905,0,"Rattus norvegicus TL0AAA45YK15 mRNA sequence","Q9JJ19",654,0,"Na(+)/H(+) exchange regulatory cofactor NHE-RF1",".",".",".",".","pfam09007","EBP50_C-term","EBP50, C-terminal. This C terminal domain allows interaction of EBP50 with FERM (four-point one ERM) domains, resulting in the activation of Ezrin-radixin-moesin (ERM), with subsequent cytoskeletal modulation and cellular growth control.","GO:0003096|renal sodium ion transport;GO:0007009|plasma membrane organization;GO:0007097|nuclear migration;GO:0007191|adenylate cyclase-activating dopamine receptor signaling pathway;GO:0007605|sensory perception of sound;GO:0008285|negative regulation of cell proliferation;GO:0008360|regulation of cell shape;GO:0008361|regulation of cell size;GO:0010642|negative regulation of platelet-derived growth factor receptor signaling pathway;GO:0010766|negative regulation of sodium ion transport;GO:0014067|negative regulation of phosphatidylinositol 3-kinase signaling;GO:0016055|Wnt signaling pathway;GO:0022612|gland morphogenesis;GO:0030033|microvillus assembly;GO:0030036|actin cytoskeleton organization;GO:0030336|negative regulation of cell migration;GO:0030643|cellular phosphate ion homeostasis;GO:0032416|negative regulation of sodium:proton antiporter activity;GO:0032782|bile acid secretion;GO:0034613|cellular protein localization;GO:0034635|glutathione transport;GO:0034767|positive regulation of ion transmembrane transport;GO:0044062|regulation of excretion;GO:0044782|cilium organization;GO:0045198|establishment of epithelial cell apical/basal polarity;GO:0045199|maintenance of epithelial cell apical/basal polarity;GO:0045859|regulation of protein kinase activity;GO:0045930|negative regulation of mitotic cell cycle;GO:0051683|establishment of Golgi localization;GO:0051898|negative regulation of protein kinase B signaling;GO:0051939|gamma-aminobutyric acid import;GO:0060088|auditory receptor cell stereocilium organization;GO:0060158|phospholipase C-activating dopamine receptor signaling pathway;GO:0070293|renal absorption;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0072659|protein localization to plasma membrane;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0090660|cerebrospinal fluid circulation;GO:0097291|renal phosphate ion absorption;GO:0098739|import across plasma membrane;GO:2000146|negative regulation of cell motility;GO:2001244|positive regulation of intrinsic apoptotic signaling pathway;","GO:0001726|ruffle;GO:0005576|extracellular region;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005902|microvillus;GO:0012505|endomembrane system;GO:0016020|membrane;GO:0016324|apical plasma membrane;GO:0030175|filopodium;GO:0031526|brush border membrane;GO:0031528|microvillus membrane;GO:0032420|stereocilium;GO:0032426|stereocilium tip;GO:0045121|membrane raft;GO:0045177|apical part of cell;GO:0048471|perinuclear region of cytoplasm;GO:0071944|cell periphery;GO:0097225|sperm midpiece;GO:0098797|plasma membrane protein complex;","GO:0005102|signaling receptor binding;GO:0005515|protein binding;GO:0008013|beta-catenin binding;GO:0015185|gamma-aminobutyric acid transmembrane transporter activity;GO:0017081|chloride channel regulator activity;GO:0019902|phosphatase binding;GO:0019904|protein domain specific binding;GO:0030165|PDZ domain binding;GO:0031698|beta-2 adrenergic receptor binding;GO:0031799|type 2 metabotropic glutamate receptor binding;GO:0031800|type 3 metabotropic glutamate receptor binding;GO:0043495|protein membrane anchor;GO:0043621|protein self-association;GO:0044877|protein-containing complex binding;GO:0045159|myosin II binding;GO:0047485|protein N-terminus binding;GO:0050780|dopamine receptor binding;GO:0060090|molecular adaptor activity;GO:0070851|growth factor receptor binding;","K13365","SLC9A3R1, NHERF1; sodium/hydrogen exchange regulatory cofactor NHE-RF1"]
["ENSRNOG00000017237",1421,119.5562167,3729,239.888204,0.498383058,-1.004673068,{"v":1.6136E-124,"d":"1.61E-124"},{"v":3.2301e-123,"d":"3.23E-123"},"down","yes","Lama1","protein_coding","chr9:107692770-107817478:+","gi|312147379|ref|NP_001101707.2|",16083,0,"laminin subunit alpha-1 precursor [Rattus norvegicus]","gi|312147378|ref|NM_001108237.2|",10570,0,"Rattus norvegicus laminin subunit alpha 1 (Lama1), mRNA","P19137",5793,0,"Laminin subunit alpha-1",".",".",".",".","pfam00055","Laminin_N","Laminin N-terminal (Domain VI).","GO:0002011|morphogenesis of an epithelial sheet;GO:0006468|protein phosphorylation;GO:0007155|cell adhesion;GO:0007166|cell surface receptor signaling pathway;GO:0007411|axon guidance;GO:0008150|biological_process;GO:0009887|animal organ morphogenesis;GO:0009888|tissue development;GO:0030155|regulation of cell adhesion;GO:0030334|regulation of cell migration;GO:0031175|neuron projection development;GO:0043010|camera-type eye development;GO:0045198|establishment of epithelial cell apical/basal polarity;GO:0045995|regulation of embryonic development;GO:0048514|blood vessel morphogenesis;GO:0060041|retina development in camera-type eye;GO:0060441|epithelial tube branching involved in lung morphogenesis;GO:0060445|branching involved in salivary gland morphogenesis;GO:0061304|retinal blood vessel morphogenesis;","GO:0005575|cellular_component;GO:0005604|basement membrane;GO:0005606|laminin-1 complex;GO:0005608|laminin-3 complex;GO:0005615|extracellular space;GO:0005911|cell-cell junction;GO:0016020|membrane;GO:0031012|extracellular matrix;GO:0043256|laminin complex;","GO:0003674|molecular_function;GO:0005102|signaling receptor binding;GO:0005201|extracellular matrix structural constituent;GO:0008022|protein C-terminus binding;GO:0043208|glycosphingolipid binding;","K05637","LAMA1_2; laminin, alpha 1/2"]
["ENSRNOG00000065022",35,2.944734403,665,42.77974139,0.068834787,-3.860718339,{"v":6.9167e-122,"d":"6.92E-122"},{"v":1.345E-120,"d":"1.35E-120"},"down","yes","RGD1560394","protein_coding","chr14:76768146-76773575:-","gi|564384243|ref|XP_006251255.1|",472,{"v":1E-50,"d":"1.00E-50"},"PREDICTED: neuropeptide-like protein C4orf48 homolog isoform X1 [Rattus norvegicus]","gi|672076586|ref|XM_006251193.2|",509,0,"PREDICTED: Rattus norvegicus RGD1560394 (RGD1560394), transcript variant X1, mRNA","Q3UR78",126,{"v":6e-32,"d":"6.00E-32"},"Neuropeptide-like protein C4orf48 homolog",".",".",".",".","pfam15161","Neuropep_like","Neuropeptide-like. This family contains putative neuropeptides.",".",".",".",".","."]
["ENSRNOG00000064231",694,58.38987644,2297,147.7670165,0.39514824,-1.339534114,{"v":1.8825E-121,"d":"1.88E-121"},{"v":3.6219e-120,"d":"3.62E-120"},"down","yes","ENSRNOG00000064231","lncRNA","chrX:69859465-69941747:+","gi|667282457|ref|XP_008574777.1|",511,{"v":7e-56,"d":"7.00E-56"},"PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103593548 [Galeopterus variegatus]","gi|1213335|gb|U48828.1|RNU48828",2791,0,"Rattus norvegicus retroviral-like ovarian specific transcript 30-1 mRNA","Q9TTC1",151,{"v":4E-35,"d":"4.00E-35"},"Gag-Pol polyprotein",".",".",".",".","pfam02093","Gag_p30","Gag P30 core shell protein. According to Swiss-Prot annotation this protein is the viral core shell protein. P30 is essential for viral assembly.",".",".",".",".","."]
["ENSRNOG00000016977",638,53.6783014,2173,139.7900422,0.383992311,-1.380850671,{"v":2.2536e-120,"d":"2.25E-120"},{"v":4.3055e-119,"d":"4.31E-119"},"down","yes","Calb2","protein_coding","chr19:38114424-38141438:-","gi|672084703|ref|XP_008770688.1|",1282,{"v":4e-171,"d":"4.00E-171"},"PREDICTED: calretinin isoform X1 [Rattus norvegicus]","gi|672084702|ref|XM_008772466.1|",1304,0,"PREDICTED: Rattus norvegicus calbindin 2 (Calb2), transcript variant X1, mRNA","P47728",494,{"v":3e-172,"d":"3.00E-172"},"Calretinin",".",".",".",".","pfam13499","EF-hand_7","EF-hand domain pair.","GO:0008150|biological_process;GO:0051480|regulation of cytosolic calcium ion concentration;GO:0099509|regulation of presynaptic cytosolic calcium ion concentration;GO:1900271|regulation of long-term synaptic potentiation;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005921|gap junction;GO:0030425|dendrite;GO:0032420|stereocilium;GO:0032437|cuticular plate;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0045202|synapse;GO:0097060|synaptic membrane;GO:0098688|parallel fiber to Purkinje cell synapse;GO:0099096|vestibular calyx terminal;","GO:0005509|calcium ion binding;GO:0099534|calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration;","K23908","CALB2; calretinin"]
["ENSRNOG00000036693",698,58.72641752,2295,147.6383556,0.397772092,-1.329986037,{"v":4.8345E-120,"d":"4.83E-120"},{"v":9.2039e-119,"d":"9.20E-119"},"down","yes","Slc25a10","protein_coding","chr10:105765372-105773556:+","gi|19173788|ref|NP_596909.1|",1361,{"v":3e-177,"d":"3.00E-177"},"mitochondrial dicarboxylate carrier [Rattus norvegicus]","gi|51859427|gb|BC081734.1|",1801,0,"Rattus norvegicus solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10, mRNA (cDNA clone MGC:93224 IMAGE:7108552), complete cds","Q9QZD8",514,{"v":5e-173,"d":"5.00E-173"},"Mitochondrial dicarboxylate carrier",".",".",".",".","pfam00153","Mito_carr","Mitochondrial carrier protein.","GO:0006817|phosphate ion transport;GO:0006839|mitochondrial transport;GO:0008272|sulfate transport;GO:0015709|thiosulfate transport;GO:0015729|oxaloacetate transport;GO:0015743|malate transport;GO:0015744|succinate transport;GO:0035435|phosphate ion transmembrane transport;GO:0071422|succinate transmembrane transport;GO:0071423|malate transmembrane transport;GO:1902356|oxaloacetate(2-) transmembrane transport;GO:1902358|sulfate transmembrane transport;","GO:0005654|nucleoplasm;GO:0005739|mitochondrion;GO:0016021|integral component of membrane;GO:0031966|mitochondrial membrane;","GO:0015114|phosphate ion transmembrane transporter activity;GO:0015116|sulfate transmembrane transporter activity;GO:0015117|thiosulfate transmembrane transporter activity;GO:0015131|oxaloacetate transmembrane transporter activity;GO:0015140|malate transmembrane transporter activity;GO:0015141|succinate transmembrane transporter activity;GO:0015291|secondary active transmembrane transporter activity;GO:0015297|antiporter activity;","K13577","SLC25A10, DIC; solute carrier family 25 (mitochondrial dicarboxylate transporter), member 10"]
["ENSRNOG00000010617",159,13.37750771,1050,67.54696009,0.198047517,-2.336081483,{"v":1.462e-119,"d":"1.46E-119"},{"v":2.7544e-118,"d":"2.75E-118"},"down","yes","Scube1","protein_coding","chr7:114759010-114880940:-","gi|564361208|ref|XP_006242154.1|",4750,0,"PREDICTED: signal peptide, CUB and EGF-like domain-containing protein 1 isoform X1 [Rattus norvegicus]","gi|672060007|ref|XM_006242092.2|",2817,0,"PREDICTED: Rattus norvegicus signal peptide, CUB domain, EGF-like 1 (Scube1), transcript variant X1, mRNA","Q6NZL8",1772,0,"Signal peptide, CUB and EGF-like domain-containing protein 1",".",".",".",".","pfam00431","CUB","CUB domain.","GO:0007165|signal transduction;GO:0045880|positive regulation of smoothened signaling pathway;","GO:0005615|extracellular space;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0019897|extrinsic component of plasma membrane;","GO:0005509|calcium ion binding;GO:0042802|identical protein binding;","K24468","SCUBE1_3; signal peptide, CUB and EGF-like domain-containing protein 1/3"]
["ENSRNOG00000016752",525,44.17101604,1927,123.9647544,0.356319151,-1.488758069,{"v":1.538E-119,"d":"1.54E-119"},{"v":2.8877E-118,"d":"2.89E-118"},"down","yes","Crispld2","protein_coding","chr19:48053287-48110465:+","gi|158533986|ref|NP_612527.2|",2606,0,"cysteine-rich secretory protein LCCL domain-containing 2 precursor [Rattus norvegicus]","gi|672085174|ref|XM_006255708.2|",3030,0,"PREDICTED: Rattus norvegicus cysteine-rich secretory protein LCCL domain containing 2 (Crispld2), transcript variant X1, mRNA","Q8BZQ2",940,0,"Cysteine-rich secretory protein LCCL domain-containing 2","YJL078c_1",61.2,1e-09,"COG2340","pfam03815","LCCL","LCCL domain.","GO:0030198|extracellular matrix organization;GO:0030324|lung development;GO:0060325|face morphogenesis;","GO:0005615|extracellular space;GO:0030133|transport vesicle;GO:0031012|extracellular matrix;","GO:0005539|glycosaminoglycan binding;GO:0008201|heparin binding;","K24243","CRISPLD; cysteine-rich secretory protein LCCL domain-containing"]
["ENSRNOG00000067807",630,53.00521925,2146,138.0531203,0.383947999,-1.381017168,{"v":6.3486e-119,"d":"6.35E-119"},{"v":1.1798E-117,"d":"1.18E-117"},"down","yes","ENSRNOG00000067807","lncRNA","chr14:45191986-45197244:-","gi|149027698|gb|EDL83221.1|",181,{"v":2e-15,"d":"2.00E-15"},"rCG29124 [Rattus norvegicus]","gi|241982901|gb|AC136178.3|",929,0,"Rattus norvegicus CH230-435P16 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P26804",53.1,{"v":2e-13,"d":"2.00E-13"},"Envelope glycoprotein",".",".",".",".","pfam00429","TLV_coat","ENV polyprotein (coat polyprotein).",".",".",".",".","."]
["ENSRNOG00000009946",1319,110.9744193,3485,224.1915771,0.494998165,-1.014504917,{"v":2.3558E-118,"d":"2.36E-118"},{"v":4.3333e-117,"d":"4.33E-117"},"down","yes","Ldlr","protein_coding","chr8:20270041-20294580:+","gi|149020469|gb|EDL78274.1|",4436,0,"low density lipoprotein receptor, isoform CRA_a [Rattus norvegicus]","gi|31343479|ref|NM_175762.2|",3015,0,"Rattus norvegicus low density lipoprotein receptor (Ldlr), mRNA","P35952",1702,0,"Low-density lipoprotein receptor",".",".",".",".","pfam00057","Ldl_recept_a","Low-density lipoprotein receptor domain class A.","GO:0001666|response to hypoxia;GO:0006629|lipid metabolic process;GO:0006897|endocytosis;GO:0006898|receptor-mediated endocytosis;GO:0006909|phagocytosis;GO:0007568|aging;GO:0007616|long-term memory;GO:0008203|cholesterol metabolic process;GO:0009725|response to hormone;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010867|positive regulation of triglyceride biosynthetic process;GO:0010898|positive regulation of triglyceride catabolic process;GO:0010899|regulation of phosphatidylcholine catabolic process;GO:0015914|phospholipid transport;GO:0030299|intestinal cholesterol absorption;GO:0030301|cholesterol transport;GO:0032355|response to estradiol;GO:0033762|response to glucagon;GO:0034381|plasma lipoprotein particle clearance;GO:0034383|low-density lipoprotein particle clearance;GO:0034384|high-density lipoprotein particle clearance;GO:0042157|lipoprotein metabolic process;GO:0042159|lipoprotein catabolic process;GO:0042632|cholesterol homeostasis;GO:0043627|response to estrogen;GO:0045056|transcytosis;GO:0045471|response to ethanol;GO:0048844|artery morphogenesis;GO:0050729|positive regulation of inflammatory response;GO:0051246|regulation of protein metabolic process;GO:0051248|negative regulation of protein metabolic process;GO:0061771|response to caloric restriction;GO:0061889|negative regulation of astrocyte activation;GO:0070508|cholesterol import;GO:0071398|cellular response to fatty acid;GO:0071404|cellular response to low-density lipoprotein particle stimulus;GO:0090118|receptor-mediated endocytosis involved in cholesterol transport;GO:0090181|regulation of cholesterol metabolic process;GO:0097242|amyloid-beta clearance;GO:0150094|amyloid-beta clearance by cellular catabolic process;GO:1903979|negative regulation of microglial cell activation;GO:1905167|positive regulation of lysosomal protein catabolic process;GO:1905907|negative regulation of amyloid fibril formation;","GO:0005764|lysosome;GO:0005768|endosome;GO:0005769|early endosome;GO:0005770|late endosome;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005901|caveola;GO:0005905|clathrin-coated pit;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0034362|low-density lipoprotein particle;GO:0036477|somatodendritic compartment;GO:0043235|receptor complex;GO:0045177|apical part of cell;GO:0055038|recycling endosome membrane;GO:0097443|sorting endosome;GO:1990666|PCSK9-LDLR complex;","GO:0001540|amyloid-beta binding;GO:0002020|protease binding;GO:0005041|low-density lipoprotein particle receptor activity;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0030169|low-density lipoprotein particle binding;GO:0030229|very-low-density lipoprotein particle receptor activity;GO:0042802|identical protein binding;GO:0071813|lipoprotein particle binding;","K12473","LDLR; low-density lipoprotein receptor"]
["ENSRNOG00000005660",123,10.34863804,937,60.27762058,0.171682922,-2.542181558,{"v":1.134e-117,"d":"1.13E-117"},{"v":2.072e-116,"d":"2.07E-116"},"down","yes","Fam110c","protein_coding","chr6:47638276-47644634:+","gi|68163531|ref|NP_001020222.1|",1318,{"v":1E-169,"d":"1.00E-169"},"protein FAM110C [Rattus norvegicus]","gi|68163530|ref|NM_001025051.1|",3024,0,"Rattus norvegicus family with sequence similarity 110, member C (Fam110c), mRNA","Q5RKJ0",512,{"v":4e-171,"d":"4.00E-171"},"Protein FAM110C",".",".",".",".","pfam14160","FAM110_C","Centrosome-associated C terminus. This is the C-terminus of a family of proteins that colocalize with the centrosome/microtubule organisation centre in interphase and at the spindle poles in mitosis.","GO:0030335|positive regulation of cell migration;GO:0051897|positive regulation of protein kinase B signaling;GO:0060491|regulation of cell projection assembly;","GO:0000922|spindle pole;GO:0005634|nucleus;GO:0005815|microtubule organizing center;GO:0005874|microtubule;GO:0005938|cell cortex;","GO:0043014|alpha-tubulin binding;",".","."]
["ENSRNOG00000004466",1042,87.66894993,2955,190.0964448,0.461181428,-1.116593678,{"v":2.3469e-117,"d":"2.35E-117"},{"v":4.2454e-116,"d":"4.25E-116"},"down","yes","Fam210b","protein_coding","chr3:161118239-161128397:+","gi|157818493|ref|NP_001100017.1|",805,{"v":4e-96,"d":"4.00E-96"},"protein FAM210B [Rattus norvegicus]","gi|298896680|emb|FQ218214.1|",3242,0,"Rattus norvegicus TL0ABA7YH02 mRNA sequence","Q9D8B6",278,{"v":1E-84,"d":"1.00E-84"},"Protein FAM210B, mitochondrial",".",".",".",".","pfam06916","DUF1279","Protein of unknown function (DUF1279). This family represents the C-terminus (approx. 120 residues) of a number of eukaryotic proteins of unknown function.","GO:0045648|positive regulation of erythrocyte differentiation;GO:0071392|cellular response to estradiol stimulus;","GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0031224|intrinsic component of membrane;",".",".","."]
["ENSRNOG00000016541",891,74.96452436,2650,170.4756612,0.439737402,-1.185285848,{"v":7.9751e-116,"d":"7.98E-116"},{"v":1.4284E-114,"d":"1.43E-114"},"down","yes","Enc1","protein_coding","chr2:28550464-28562713:+","gi|826351127|ref|XP_012520060.1|",3098,0,"PREDICTED: ectoderm-neural cortex protein 1 isoform X1 [Propithecus coquereli]","gi|50979279|ref|NM_001003401.1|",2398,0,"Rattus norvegicus ectodermal-neural cortex 1 (Enc1), mRNA","O35709",1193,0,"Ectoderm-neural cortex protein 1",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.","GO:0007399|nervous system development;GO:0010499|proteasomal ubiquitin-independent protein catabolic process;GO:0010976|positive regulation of neuron projection development;GO:0016567|protein ubiquitination;GO:0017148|negative regulation of translation;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0016363|nuclear matrix;GO:0031463|Cul3-RING ubiquitin ligase complex;GO:0043025|neuronal cell body;","GO:0003779|actin binding;","K10462","KLHL25_37, ENC1, ENC2; kelch-like protein 25/37 (ectoderm-neural cortex protein)"]
["ENSRNOG00000066193",403,33.90651326,1615,103.8936577,0.326357874,-1.615473246,{"v":5.2727e-113,"d":"5.27E-113"},{"v":9.261e-112,"d":"9.26E-112"},"down","yes","Zfp862","protein_coding","chr4:77453037-77481995:+","gi|672018269|ref|XP_008773951.1|",5440,0,"PREDICTED: zinc finger protein 862 [Rattus norvegicus]","gi|169235008|gb|AC135090.3|",6728,0,"Rattus norvegicus BAC CH230-446D1 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","O60290",1522,0,"Zinc finger protein 862",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000051563",633,53.25762505,2104,135.3512419,0.39347718,-1.345648125,{"v":3.5256e-112,"d":"3.53E-112"},{"v":6.1331e-111,"d":"6.13E-111"},"down","yes","Giot1","protein_coding","chr7:10202982-10237099:-","gi|149034696|gb|EDL89433.1|",3512,0,"rCG29351 [Rattus norvegicus]","gi|19424247|ref|NM_133563.1|",2544,0,"Rattus norvegicus gonadotropin inducible ovarian transcription factor 1 (Giot1), mRNA","Q8N972",582,0,"Zinc finger protein 709",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0000122|negative regulation of transcription by RNA polymerase II;","GO:0005737|cytoplasm;","GO:0046872|metal ion binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSRNOG00000060550",977,82.20015747,2786,179.2246008,0.458643273,-1.124555616,{"v":5.2203e-112,"d":"5.22E-112"},{"v":9.0234e-111,"d":"9.02E-111"},"down","yes","Epn2","protein_coding","chr10:46197785-46259642:-","gi|76781456|ref|NP_001029086.1|",2943,0,"epsin-2 isoform b [Rattus norvegicus]","gi|779176544|ref|NM_001305628.1|",4414,0,"Rattus norvegicus epsin 2 (Epn2), transcript variant 3, mRNA","O95208",989,0,"Epsin-2",".",".",".",".","pfam01417","ENTH","ENTH domain. The ENTH (Epsin N-terminal homology) domain is found in proteins involved in endocytosis and cytoskeletal machinery. The function of the ENTH domain is unknown.","GO:0001701|in utero embryonic development;GO:0006897|endocytosis;GO:0007219|Notch signaling pathway;GO:0030100|regulation of endocytosis;GO:0030948|negative regulation of vascular endothelial growth factor receptor signaling pathway;GO:0045747|positive regulation of Notch signaling pathway;GO:0048568|embryonic organ development;GO:1903671|negative regulation of sprouting angiogenesis;","GO:0005768|endosome;GO:0005886|plasma membrane;GO:0030125|clathrin vesicle coat;GO:0030128|clathrin coat of endocytic vesicle;GO:0043231|intracellular membrane-bounded organelle;","GO:0005543|phospholipid binding;GO:0008289|lipid binding;GO:0030276|clathrin binding;","K12471","EPN; epsin"]
["ENSRNOG00000000942",1266,106.5152501,3314,213.1910721,0.499623408,-1.001087023,{"v":3.0888e-110,"d":"3.09E-110"},{"v":5.1907e-109,"d":"5.19E-109"},"down","yes","Pan3","protein_coding","chr12:7476697-7599204:-","gi|564314926|ref|XP_006221312.1|",4186,0,"PREDICTED: PAB-dependent poly(A)-specific ribonuclease subunit PAN3 isoform X2 [Rattus norvegicus]","gi|672072252|ref|XM_006248842.2|",5081,0,"PREDICTED: Rattus norvegicus PAN3 poly(A) specific ribonuclease subunit (Pan3), transcript variant X1, mRNA","Q58A45",1533,0,"PAN2-PAN3 deadenylation complex subunit PAN3",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0000289|nuclear-transcribed mRNA poly(A) tail shortening;GO:0000290|deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0006397|mRNA processing;GO:0006468|protein phosphorylation;GO:0006605|protein targeting;GO:0008150|biological_process;GO:0010606|positive regulation of cytoplasmic mRNA processing body assembly;GO:0090503|RNA phosphodiester bond hydrolysis, exonucleolytic;","GO:0000932|P-body;GO:0005575|cellular_component;GO:0031251|PAN complex;","GO:0003674|molecular_function;GO:0003723|RNA binding;GO:0004535|poly(A)-specific ribonuclease activity;GO:0004672|protein kinase activity;GO:0005524|ATP binding;GO:0008143|poly(A) binding;","K12572","PAN3; PAB-dependent poly(A)-specific ribonuclease subunit 3"]
["ENSRNOG00000049629",83,6.983227298,757,48.69814171,0.143398229,-2.801900884,{"v":9.5957e-106,"d":"9.60E-106"},{"v":1.5596e-104,"d":"1.56E-104"},"down","yes","Reep2","protein_coding","chr18:26438346-26447161:+","gi|532025987|ref|XP_005355979.1|",1223,{"v":2E-160,"d":"2.00E-160"},"PREDICTED: receptor expression-enhancing protein 2 isoform X1 [Microtus ochrogaster]","gi|114158667|ref|NM_001048047.1|",1751,0,"Rattus norvegicus receptor accessory protein 2 (Reep2), mRNA","Q8VCD6",461,{"v":2e-156,"d":"2.00E-156"},"Receptor expression-enhancing protein 2","SPBC30D10.09c",65.9,{"v":3E-11,"d":"3.00E-11"},"COG5052","pfam03134","TB2_DP1_HVA22","TB2/DP1, HVA22 family. This family includes members from a wide variety of eukaryotes. It includes the TB2/DP1 (deleted in polyposis) protein, which in humans is deleted in severe forms of familial adenomatous polyposis, an autosomal dominant oncological inherited disease. The family also includes the plant protein of known similarity to TB2/DP1, the HVA22 abscisic acid-induced protein, which is thought to be a regulatory protein.","GO:0032386|regulation of intracellular transport;GO:0032596|protein transport into membrane raft;GO:0050913|sensory perception of bitter taste;GO:0050916|sensory perception of sweet taste;GO:0071786|endoplasmic reticulum tubular network organization;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005881|cytoplasmic microtubule;GO:0005887|integral component of plasma membrane;","GO:0031883|taste receptor binding;","K17338","REEP1_2_3_4; receptor expression-enhancing protein 1/2/3/4"]
["ENSRNOG00000018782",214,18.00494749,1121,72.11442121,0.249671941,-2.001894402,{"v":1.7496e-105,"d":"1.75E-105"},{"v":2.8352E-104,"d":"2.84E-104"},"down","yes","Gmnn","protein_coding","chr17:40301808-40310054:+","gi|157820093|ref|NP_001099582.1|",1083,{"v":3e-145,"d":"3.00E-145"},"geminin [Rattus norvegicus]","gi|157820092|ref|NM_001106112.1|",1178,0,"Rattus norvegicus geminin, DNA replication inhibitor (Gmnn), mRNA","O88513",375,{"v":1e-128,"d":"1.00E-128"},"Geminin",".",".",".",".","pfam07412","Geminin","Geminin. This family contains the eukaryotic protein geminin (approximately 200 residues long). Geminin inhibits DNA replication by preventing the incorporation of MCM complex into prereplication complex, and is degraded during the mitotic phase of the cell cycle. It has been proposed that geminin inhibits DNA replication during S, G2, and M phases and that geminin destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.","GO:0006275|regulation of DNA replication;GO:0008156|negative regulation of DNA replication;GO:0009887|animal organ morphogenesis;GO:0035563|positive regulation of chromatin binding;GO:0045786|negative regulation of cell cycle;GO:0045892|negative regulation of transcription, DNA-templated;GO:0065003|protein-containing complex assembly;GO:0071163|DNA replication preinitiation complex assembly;GO:2000104|negative regulation of DNA-dependent DNA replication;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0003682|chromatin binding;GO:0003714|transcription corepressor activity;GO:0042826|histone deacetylase binding;","K10749","GMNN; geminin"]
["ENSRNOG00000010797",179,15.06021309,1028,66.13169045,0.227730654,-2.134599597,{"v":4.7886e-105,"d":"4.79E-105"},{"v":7.714E-104,"d":"7.71E-104"},"down","yes","Esm1","protein_coding","chr2:44876067-44884804:+","gi|12018274|ref|NP_072126.1|",889,{"v":4e-112,"d":"4.00E-112"},"endothelial cell-specific molecule 1 precursor [Rattus norvegicus]","gi|47575857|ref|NM_022604.2|",2084,0,"Rattus norvegicus endothelial cell-specific molecule 1 (Esm1), mRNA","P97682",347,{"v":1e-113,"d":"1.00E-113"},"Endothelial cell-specific molecule 1",".",".",".",".","pfam00219","IGFBP","Insulin-like growth factor binding protein.","GO:0001525|angiogenesis;GO:0002040|sprouting angiogenesis;GO:0008284|positive regulation of cell proliferation;GO:1902204|positive regulation of hepatocyte growth factor receptor signaling pathway;","GO:0005576|extracellular region;","GO:0005171|hepatocyte growth factor receptor binding;GO:0005178|integrin binding;GO:0005520|insulin-like growth factor binding;","K25036","ESM1; endothelial cell-specific molecule 1"]
["ENSRNOG00000024426",143,12.03134342,930,59.82730751,0.201101201,-2.314006394,{"v":6.0217e-105,"d":"6.02E-105"},{"v":9.6433e-104,"d":"9.64E-104"},"down","yes","AABR07032520.1","protein_coding","chr18:67450595-67467044:+","gi|564320831|ref|XP_006222676.1|",1531,0,"PREDICTED: protein maestro isoform X1 [Rattus norvegicus]","gi|672030818|ref|XM_006222615.2|",1403,0,"PREDICTED: Rattus norvegicus maestro (Mro), transcript variant X2, mRNA","Q7TNB4",437,{"v":6e-151,"d":"6.00E-151"},"Protein maestro",".",".",".",".","pfam03999","MAP65_ASE1","Microtubule associated protein (MAP65/ASE1 family).",".",".",".",".","."]
["ENSRNOG00000012860",1004,84.47180972,2769,178.1309833,0.474211775,-1.07639661,{"v":7.4228e-104,"d":"7.42E-104"},{"v":1.1749E-102,"d":"1.17E-102"},"down","yes","Tmem184c","protein_coding","chr19:30345290-30361269:+","gi|672084742|ref|XP_008770697.1|",2398,0,"PREDICTED: transmembrane protein 184C isoform X2 [Rattus norvegicus]","gi|672084741|ref|XM_008772475.1|",2874,0,"PREDICTED: Rattus norvegicus transmembrane protein 184C (Tmem184c), transcript variant X2, mRNA","Q810F5",920,0,"Transmembrane protein 184C",".",".",".",".","pfam03619","Solute_trans_a","Organic solute transporter Ostalpha. This family is a transmembrane organic solute transport protein. In vertebrates these proteins form a complex with Ostbeta, and function as bile transporters. In plants they may transport brassinosteroid-like compounds and act as regulators of cell death.","GO:0006810|transport;","GO:0016021|integral component of membrane;","GO:0005215|transporter activity;",".","."]
["ENSRNOG00000029861",308,25.91366274,1334,85.81680454,0.301964899,-1.727547236,{"v":7.4632e-103,"d":"7.46E-103"},{"v":1.1644E-101,"d":"1.16E-101"},"down","yes","Gsta2","protein_coding","chr8:79184322-79196798:-","gi|51036637|ref|NP_058709.2|",1006,{"v":2e-129,"d":"2.00E-129"},"glutathione S-transferase alpha-1 [Rattus norvegicus]","gi|50927556|gb|BC078706.1|",896,0,"Rattus norvegicus glutathione S-transferase A2, mRNA (cDNA clone MGC:93118 IMAGE:7128611), complete cds","P00502",392,{"v":7e-131,"d":"7.00E-131"},"Glutathione S-transferase alpha-1",".",".",".",".","pfam00043","GST_C","Glutathione S-transferase, C-terminal domain. GST conjugates reduced glutathione to a variety of targets including S-crystallin from squid, the eukaryotic elongation factor 1-gamma, the HSP26 family of stress-related proteins and auxin-regulated proteins in plants. Stringent starvation proteins in Escherichia coli are also included in the alignment but are not known to have GST activity.     The glutathione molecule binds in a cleft between N and C-terminal domains. The catalytically important residues are proposed to reside in the N-terminal domain. In plants, GSTs are encoded by a large gene family (48 GST genes in Arabidopsis) and can be divided into the phi, tau, theta, zeta, and lambda classes.","GO:0006693|prostaglandin metabolic process;GO:0006749|glutathione metabolic process;GO:0006805|xenobiotic metabolic process;GO:0007568|aging;GO:0009617|response to bacterium;GO:0030855|epithelial cell differentiation;GO:0035634|response to stilbenoid;GO:0042178|xenobiotic catabolic process;GO:0098869|cellular oxidant detoxification;GO:1901687|glutathione derivative biosynthetic process;","GO:0005829|cytosol;","GO:0004364|glutathione transferase activity;GO:0004769|steroid delta-isomerase activity;GO:0035731|dinitrosyl-iron complex binding;GO:0042803|protein homodimerization activity;GO:0043295|glutathione binding;","K00799","GST, gst; glutathione S-transferase [EC:2.5.1.18]"]
["ENSRNOG00000046256",970,81.61121059,2694,173.3062005,0.470907621,-1.086484024,{"v":1.3084e-102,"d":"1.31E-102"},{"v":2.0297E-101,"d":"2.03E-101"},"down","yes","Ralgapa1","protein_coding","chr6:72977432-73252378:-","gi|913487139|ref|XP_013202631.1|",12156,0,"PREDICTED: ral GTPase-activating protein subunit alpha-1 isoform X3 [Microtus ochrogaster]","gi|913487140|ref|XM_013347178.1|",6804,0,"PREDICTED: Microtus ochrogaster Ral GTPase activating protein, alpha subunit 1 (catalytic) (Ralgapa1), transcript variant X4, mRNA","O55007",2462,0,"Ral GTPase-activating protein subunit alpha-1",".",".",".",".","pfam02145","Rap_GAP","Rap/ran-GAP.","GO:0006355|regulation of transcription, DNA-templated;GO:0043547|positive regulation of GTPase activity;GO:0051056|regulation of small GTPase mediated signal transduction;GO:0090630|activation of GTPase activity;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0005096|GTPase activator activity;GO:0046982|protein heterodimerization activity;",".","."]
["ENSRNOG00000065003",238,20.02419394,1161,74.68763873,0.268105864,-1.899125319,{"v":5.9733e-102,"d":"5.97E-102"},{"v":9.2136e-101,"d":"9.21E-101"},"down","yes","Abcg3l4","protein_coding","chr14:4545223-4585347:-","gi|81295367|ref|NP_001032282.1|",3224,0,"ATP-binding cassette, subfamily G (WHITE), member 3-like 4 [Rattus norvegicus]","gi|81295366|ref|NM_001037205.1|",2710,0,"Rattus norvegicus ATP-binding cassette, subfamily G (WHITE), member 3-like 4 (Abcg3l4), mRNA","Q99P81",951,0,"ATP-binding cassette sub-family G member 3","SPCC18B5.01c_2",132,{"v":2e-32,"d":"2.00E-32"},"COG1131","pfam01061","ABC2_membrane","ABC-2 type transporter.",".",".",".",".","."]
["ENSRNOG00000047314",343,28.85839715,1402,90.19127434,0.319968837,-1.643996693,{"v":8.2658e-101,"d":"8.27E-101"},{"v":1.2642e-99,"d":"1.26E-99"},"down","yes","Tk1","protein_coding","chr10:103031521-103046920:-","gi|158186787|ref|NP_434687.1|",1171,{"v":7e-153,"d":"7.00E-153"},"thymidine kinase, cytosolic [Rattus norvegicus]","gi|158186786|ref|NM_052800.1|",2207,0,"Rattus norvegicus thymidine kinase 1, soluble (Tk1), mRNA","P04184",406,{"v":4e-135,"d":"4.00E-135"},"Thymidine kinase, cytosolic","MYPU_1450",94.4,{"v":9e-21,"d":"9.00E-21"},"COG1435","pfam00265","TK","Thymidine kinase.","GO:0001889|liver development;GO:0009157|deoxyribonucleoside monophosphate biosynthetic process;GO:0009636|response to toxic substance;GO:0014856|skeletal muscle cell proliferation;GO:0016310|phosphorylation;GO:0031667|response to nutrient levels;GO:0046104|thymidine metabolic process;GO:0046688|response to copper ion;GO:0048565|digestive tract development;GO:0051289|protein homotetramerization;GO:0051414|response to cortisol;GO:0060138|fetal process involved in parturition;GO:0071897|DNA biosynthetic process;","GO:0005737|cytoplasm;","GO:0003674|molecular_function;GO:0004797|thymidine kinase activity;GO:0005524|ATP binding;GO:0008270|zinc ion binding;GO:0042802|identical protein binding;","K00857","tdk, TK; thymidine kinase [EC:2.7.1.21]"]
["ENSRNOG00000008943",218,18.34148856,1099,70.69915157,0.259430109,-1.946582171,{"v":8.898e-100,"d":"8.90E-100"},{"v":1.34953E-98,"d":"1.35E-98"},"down","yes","Penk","protein_coding","chr5:17183806-17189129:-","gi|564350204|ref|XP_006237897.1|",1433,0,"PREDICTED: proenkephalin-A isoform X1 [Rattus norvegicus]","gi|564350203|ref|XM_006237835.1|",1282,0,"PREDICTED: Rattus norvegicus proenkephalin (Penk), transcript variant X1, mRNA","P04094",556,0,"Proenkephalin-A",".",".",".",".","pfam01160","Opiods_neuropep","Vertebrate endogenous opioids neuropeptide.","GO:0001649|osteoblast differentiation;GO:0001662|behavioral fear response;GO:0001666|response to hypoxia;GO:0001964|startle response;GO:0002118|aggressive behavior;GO:0007218|neuropeptide signaling pathway;GO:0007268|chemical synaptic transmission;GO:0007568|aging;GO:0007600|sensory perception;GO:0007626|locomotory behavior;GO:0009314|response to radiation;GO:0009617|response to bacterium;GO:0009636|response to toxic substance;GO:0014009|glial cell proliferation;GO:0019233|sensory perception of pain;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0034599|cellular response to oxidative stress;GO:0035094|response to nicotine;GO:0035641|locomotory exploration behavior;GO:0043278|response to morphine;GO:0045471|response to ethanol;GO:0051592|response to calcium ion;GO:0051867|general adaptation syndrome, behavioral process;GO:0071305|cellular response to vitamin D;GO:0071320|cellular response to cAMP;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0071871|response to epinephrine;GO:0098586|cellular response to virus;GO:0099538|synaptic signaling via neuropeptide;GO:2000987|positive regulation of behavioral fear response;","GO:0005576|extracellular region;GO:0005886|plasma membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0032280|symmetric synapse;GO:0034466|chromaffin granule lumen;GO:0034592|synaptic vesicle lumen;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0043679|axon terminus;GO:0070852|cell body fiber;GO:0099013|neuronal dense core vesicle lumen;","GO:0001515|opioid peptide activity;GO:0003674|molecular_function;GO:0031628|opioid receptor binding;","K18832","PENK; proenkephalin A"]
["ENSRNOG00000012879",571,48.0412384,1884,121.1985455,0.396384612,-1.33502714,{"v":1.853e-99,"d":"1.85E-99"},{"v":2.79476e-98,"d":"2.79E-98"},"down","yes","Fabp3","protein_coding","chr5:142651956-142658718:+","gi|6601500|gb|AAF19003.1|AF144090_1",601,{"v":4e-74,"d":"4.00E-74"},"fatty acid-binding protein [Rattus norvegicus]","gi|24182473|gb|AF144090.2|",754,0,"Rattus norvegicus heart fatty acid-binding protein (FABP) gene, complete cds","P07483",235,{"v":2e-75,"d":"2.00E-75"},"Fatty acid-binding protein, heart",".",".",".",".","pfam00061","Lipocalin","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.","GO:0006631|fatty acid metabolic process;GO:0006635|fatty acid beta-oxidation;GO:0009410|response to xenobiotic stimulus;GO:0015909|long-chain fatty acid transport;GO:0032365|intracellular lipid transport;GO:0032868|response to insulin;GO:0042632|cholesterol homeostasis;GO:0046320|regulation of fatty acid oxidation;GO:0050873|brown fat cell differentiation;GO:0055091|phospholipid homeostasis;GO:0070542|response to fatty acid;GO:0140214|positive regulation of long-chain fatty acid import into cell;GO:2001245|regulation of phosphatidylcholine biosynthetic process;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016528|sarcoplasm;","GO:0005324|long-chain fatty acid transporter activity;GO:0005504|fatty acid binding;GO:0008092|cytoskeletal protein binding;GO:0036041|long-chain fatty acid binding;GO:0050543|icosatetraenoic acid binding;GO:0070538|oleic acid binding;","K08752","FABP3; fatty acid-binding protein 3, muscle and heart"]
["ENSRNOG00000001275",174,14.63953674,984,63.30115117,0.231268097,-2.112361835,{"v":2.4618e-99,"d":"2.46E-99"},{"v":3.70279e-98,"d":"3.70E-98"},"down","yes","Tmem184a","protein_coding","chr12:14822898-14832065:+","gi|564378401|ref|XP_006249000.1|",2016,0,"PREDICTED: transmembrane protein 184A isoform X2 [Rattus norvegicus]","gi|672072001|ref|XM_006248938.2|",2022,0,"PREDICTED: Rattus norvegicus transmembrane protein 184A (Tmem184a), transcript variant X1, mRNA","Q4QQS1",733,0,"Transmembrane protein 184A",".",".",".",".","pfam03619","Solute_trans_a","Organic solute transporter Ostalpha. This family is a transmembrane organic solute transport protein. In vertebrates these proteins form a complex with Ostbeta, and function as bile transporters. In plants they may transport brassinosteroid-like compounds and act as regulators of cell death.","GO:0006810|transport;GO:0018992|germ-line sex determination;GO:0032880|regulation of protein localization;GO:0051046|regulation of secretion;","GO:0005768|endosome;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030658|transport vesicle membrane;GO:0030659|cytoplasmic vesicle membrane;GO:0030667|secretory granule membrane;GO:0031901|early endosome membrane;GO:0048471|perinuclear region of cytoplasm;","GO:0005215|transporter activity;GO:0008201|heparin binding;",".","."]
["ENSRNOG00000063577",591,49.72394377,1920,123.5144413,0.402575952,-1.312667101,{"v":9.0783E-99,"d":"9.08E-99"},{"v":1.36171e-97,"d":"1.36E-97"},"down","yes","ENSRNOG00000063577","protein_coding","chr1:61368076-61395282:+","gi|672034684|ref|XP_008757045.1|",3362,0,"PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 678-like isoform X2 [Rattus norvegicus]","gi|672034683|ref|XM_008758823.1|",2088,0,"PREDICTED: Rattus norvegicus zinc finger protein 420-like (LOC102550851), transcript variant X2, mRNA","Q8TAQ5",548,0,"Zinc finger protein 420",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000008209",850,71.51497835,2431,156.3872952,0.457294042,-1.128805972,{"v":1.44119E-98,"d":"1.44E-98"},{"v":2.15578e-97,"d":"2.16E-97"},"down","yes","St3gal1","protein_coding","chr7:98845270-98913236:-","gi|564360299|ref|XP_006241771.1|",1375,{"v":3E-171,"d":"3.00E-171"},"PREDICTED: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1 [Rattus norvegicus]","gi|672059218|ref|XM_006241709.2|",5552,0,"PREDICTED: Rattus norvegicus ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (St3gal1), transcript variant X1, mRNA","P54751",514,{"v":2E-165,"d":"2.00E-165"},"CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1",".",".",".",".","pfam00777","Glyco_transf_29","Glycosyltransferase family 29 (sialyltransferase). Members of this family belong to glycosyltransferase family 29.","GO:0002319|memory B cell differentiation;GO:0006054|N-acetylneuraminate metabolic process;GO:0006468|protein phosphorylation;GO:0006486|protein glycosylation;GO:0006487|protein N-linked glycosylation;GO:0010706|ganglioside biosynthetic process via lactosylceramide;GO:0097503|sialylation;GO:1905403|negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process;GO:1990743|protein sialylation;","GO:0016021|integral component of membrane;GO:0032588|trans-Golgi network membrane;GO:1990675|Golgi medial cisterna membrane;GO:1990676|Golgi trans cisterna membrane;","GO:0003836|beta-galactoside (CMP) alpha-2,3-sialyltransferase activity;","K00780","SIAT4A; beta-galactoside alpha-2,3-sialyltransferase (sialyltransferase 4A) [EC:2.4.99.4]"]
["ENSRNOG00000011135",606,50.9859728,1944,125.0583718,0.407697398,-1.294429345,{"v":7.05346e-98,"d":"7.05E-98"},{"v":1.04932E-96,"d":"1.05E-96"},"down","yes","Gtf2b","protein_coding","chr2:231767238-231785651:+","gi|635106759|ref|XP_007976241.1|",1378,{"v":2E-179,"d":"2.00E-179"},"PREDICTED: transcription initiation factor IIB [Chlorocebus sabaeus]","gi|298898349|emb|FQ231337.1|",851,0,"Rattus norvegicus TL0AEA6YN24 mRNA sequence","P62916",530,{"v":5e-180,"d":"5.00E-180"},"Transcription initiation factor IIB","SPAC16E8.16",206,{"v":5e-58,"d":"5.00E-58"},"COG1405","pfam00382","TFIIB","Transcription factor TFIIB repeat.","GO:0001174|transcriptional start site selection at RNA polymerase II promoter;GO:0006352|DNA-templated transcription, initiation;GO:0006366|transcription by RNA polymerase II;GO:0006367|transcription initiation from RNA polymerase II promoter;GO:0006473|protein acetylation;GO:0016573|histone acetylation;GO:0019083|viral transcription;GO:0051123|RNA polymerase II preinitiation complex assembly;GO:0070897|transcription preinitiation complex assembly;GO:1904798|positive regulation of core promoter binding;GO:1990114|RNA polymerase II core complex assembly;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005669|transcription factor TFIID complex;GO:0005694|chromosome;GO:0016604|nuclear body;GO:0032993|protein-DNA complex;GO:0090575|RNA polymerase II transcription factor complex;GO:0097550|transcriptional preinitiation complex;","GO:0000979|RNA polymerase II core promoter sequence-specific DNA binding;GO:0000993|RNA polymerase II complex binding;GO:0003677|DNA binding;GO:0004402|histone acetyltransferase activity;GO:0008270|zinc ion binding;GO:0016251|RNA polymerase II general transcription initiation factor activity;GO:0016407|acetyltransferase activity;GO:0017025|TBP-class protein binding;GO:0046966|thyroid hormone receptor binding;GO:1990841|promoter-specific chromatin binding;","K03124","TFIIB, GTF2B, SUA7, tfb; transcription initiation factor TFIIB"]
["ENSRNOG00000000903",694,58.38987644,2118,136.2518681,0.428543676,-1.222485847,{"v":1.5948e-97,"d":"1.59E-97"},{"v":2.35963E-96,"d":"2.36E-96"},"down","yes","Asl","protein_coding","chr12:26659565-26679662:+","gi|31377525|ref|NP_067588.2|",2465,0,"argininosuccinate lyase [Rattus norvegicus]","gi|148747348|ref|NM_021577.3|",2073,0,"Rattus norvegicus argininosuccinate lyase (Asl), mRNA","P20673",947,0,"Argininosuccinate lyase","SPBC1539.03c",566,0,"COG0165","pfam00206","Lyase_1","Lyase.","GO:0000050|urea cycle;GO:0000053|argininosuccinate metabolic process;GO:0001822|kidney development;GO:0001889|liver development;GO:0006520|cellular amino acid metabolic process;GO:0006526|arginine biosynthetic process;GO:0007494|midgut development;GO:0007568|aging;GO:0007584|response to nutrient;GO:0007626|locomotory behavior;GO:0009410|response to xenobiotic stimulus;GO:0009636|response to toxic substance;GO:0009791|post-embryonic development;GO:0010043|response to zinc ion;GO:0014075|response to amine;GO:0019676|ammonia assimilation cycle;GO:0032496|response to lipopolysaccharide;GO:0042450|arginine biosynthetic process via ornithine;GO:0043434|response to peptide hormone;GO:0048545|response to steroid hormone;GO:0060416|response to growth hormone;GO:0060539|diaphragm development;GO:0071242|cellular response to ammonium ion;GO:0071320|cellular response to cAMP;GO:0071346|cellular response to interferon-gamma;GO:0071356|cellular response to tumor necrosis factor;GO:0071377|cellular response to glucagon stimulus;GO:0071385|cellular response to glucocorticoid stimulus;GO:0071456|cellular response to hypoxia;GO:0071549|cellular response to dexamethasone stimulus;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005741|mitochondrial outer membrane;GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0048471|perinuclear region of cytoplasm;GO:0070852|cell body fiber;","GO:0004056|argininosuccinate lyase activity;GO:0042802|identical protein binding;","K01755","argH, ASL; argininosuccinate lyase [EC:4.3.2.1]"]
["ENSRNOG00000012280",122,10.26450277,832,53.52292457,0.191777689,-2.382493206,{"v":2.45756e-97,"d":"2.46E-97"},{"v":3.6263e-96,"d":"3.63E-96"},"down","yes","Ptx3","protein_coding","chr2:150487513-150493323:+","gi|157817545|ref|NP_001103006.1|",1933,0,"pentraxin-related protein PTX3 precursor [Rattus norvegicus]","gi|157817544|ref|NM_001109536.1|",1920,0,"Rattus norvegicus pentraxin 3 (Ptx3), mRNA","P48759",709,0,"Pentraxin-related protein PTX3",".",".",".",".","pfam00354","Pentaxin","Pentaxin family. Pentaxins are also known as pentraxins.","GO:0001550|ovarian cumulus expansion;GO:0001878|response to yeast;GO:0008228|opsonization;GO:0030198|extracellular matrix organization;GO:0044793|negative regulation by host of viral process;GO:0044869|negative regulation by host of viral exo-alpha-sialidase activity;GO:0044871|negative regulation by host of viral glycoprotein metabolic process;GO:0045087|innate immune response;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0046597|negative regulation of viral entry into host cell;GO:0050766|positive regulation of phagocytosis;GO:1903016|negative regulation of exo-alpha-sialidase activity;GO:1903019|negative regulation of glycoprotein metabolic process;","GO:0005615|extracellular space;GO:0031012|extracellular matrix;","GO:0001849|complement component C1q binding;GO:0001872|(1->3)-beta-D-glucan binding;GO:0042802|identical protein binding;GO:0046790|virion binding;","K25724","PTX3; pentraxin-related protein PTX3"]
["ENSRNOG00000017601",335,28.185315,1356,87.23207418,0.323107243,-1.629915003,{"v":2.15257e-96,"d":"2.15E-96"},{"v":3.1422e-95,"d":"3.14E-95"},"down","yes","Srd5a1","protein_coding","chr1:33686391-33720461:+","gi|2507119|sp|P24008.2|S5A1_RAT",1195,{"v":2e-154,"d":"2.00E-154"},"RecName: Full=3-oxo-5-alpha-steroid 4-dehydrogenase 1; AltName: Full=SR type 1; AltName: Full=Steroid 5-alpha-reductase 1; Short=S5AR 1","gi|117558799|gb|BC127454.1|",2613,0,"Rattus norvegicus steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1), mRNA (cDNA clone MGC:156498 IMAGE:7313862), complete cds","P24008",464,{"v":7e-156,"d":"7.00E-156"},"3-oxo-5-alpha-steroid 4-dehydrogenase 1",".",".",".",".","pfam02544","Steroid_dh","3-oxo-5-alpha-steroid 4-dehydrogenase. This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalysed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor <=> 3-oxo-delta(4)-steroid + reduced acceptor. The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally. A related enzyme is also found in plants is DET2, a steroid reductase from Arabidopsis. Mutations in this enzyme cause defects in light-regulated development.","GO:0001655|urogenital system development;GO:0001889|liver development;GO:0006694|steroid biosynthetic process;GO:0006702|androgen biosynthetic process;GO:0006710|androgen catabolic process;GO:0008209|androgen metabolic process;GO:0008584|male gonad development;GO:0009267|cellular response to starvation;GO:0009410|response to xenobiotic stimulus;GO:0014070|response to organic cyclic compound;GO:0014850|response to muscle activity;GO:0016101|diterpenoid metabolic process;GO:0021510|spinal cord development;GO:0021766|hippocampus development;GO:0021794|thalamus development;GO:0021854|hypothalamus development;GO:0021983|pituitary gland development;GO:0021987|cerebral cortex development;GO:0030154|cell differentiation;GO:0030539|male genitalia development;GO:0030540|female genitalia development;GO:0032354|response to follicle-stimulating hormone;GO:0032355|response to estradiol;GO:0032869|cellular response to insulin stimulus;GO:0033574|response to testosterone;GO:0042428|serotonin metabolic process;GO:0042448|progesterone metabolic process;GO:0042747|circadian sleep/wake cycle, REM sleep;GO:0043627|response to estrogen;GO:0046661|male sex differentiation;GO:0060348|bone development;GO:0060416|response to growth hormone;GO:0060992|response to fungicide;GO:0071320|cellular response to cAMP;GO:0071363|cellular response to growth factor stimulus;GO:0071392|cellular response to estradiol stimulus;GO:0071394|cellular response to testosterone stimulus;GO:0071407|cellular response to organic cyclic compound;GO:0071549|cellular response to dexamethasone stimulus;GO:0071872|cellular response to epinephrine stimulus;","GO:0005737|cytoplasm;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0043025|neuronal cell body;GO:0043209|myelin sheath;GO:0043231|intracellular membrane-bounded organelle;GO:0048471|perinuclear region of cytoplasm;GO:0070852|cell body fiber;","GO:0003865|3-oxo-5-alpha-steroid 4-dehydrogenase activity;GO:0016491|oxidoreductase activity;GO:0033218|amide binding;GO:0047751|cholestenone 5-alpha-reductase activity;GO:0050213|progesterone 5-alpha-reductase activity;GO:0070402|NADPH binding;","K12343","SRD5A1; 3-oxo-5-alpha-steroid 4-dehydrogenase 1 [EC:1.3.1.22]"]
["ENSRNOG00000052894",733,61.67115192,2181,140.3046857,0.43955162,-1.185895492,{"v":9.57712E-96,"d":"9.58E-96"},{"v":1.38686e-94,"d":"1.39E-94"},"down","yes","Epg5","protein_coding","chr18:71404010-71501502:+","gi|564320912|ref|XP_006222699.1|",13344,0,"PREDICTED: ectopic P granules protein 5 homolog [Rattus norvegicus]","gi|672030872|ref|XM_006222637.2|",9565,0,"PREDICTED: Rattus norvegicus ectopic P-granules autophagy protein 5 homolog (C. elegans) (Epg5), transcript variant X1, mRNA","Q80TA9",4710,0,"Ectopic P granules protein 5 homolog",".",".",".",".","pfam01500","Keratin_B2","Keratin, high sulfur B2 protein. High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.","GO:0006862|nucleotide transport;GO:0006914|autophagy;GO:0008333|endosome to lysosome transport;GO:0032456|endocytic recycling;GO:0034162|toll-like receptor 9 signaling pathway;GO:0097352|autophagosome maturation;GO:1990786|cellular response to dsDNA;","GO:0005764|lysosome;GO:0048471|perinuclear region of cytoplasm;",".","K23883","EPG5; ectopic P granules protein 5"]
["ENSRNOG00000046333",985,82.87323962,2658,170.9903047,0.484666308,-1.0449363,{"v":3.81228e-95,"d":"3.81E-95"},{"v":5.41966e-94,"d":"5.42E-94"},"down","yes","AABR07007032.1","protein_coding","chr1:256084297-256371969:-","gi|157057145|ref|NP_848803.3|",4016,0,"actin-binding LIM protein 1 isoform 1 [Mus musculus]","gi|672015104|ref|XM_008774890.1|",6298,0,"PREDICTED: Rattus norvegicus actin-binding LIM protein 1 (Ablim1), transcript variant X6, mRNA","Q8K4G5",1551,0,"Actin-binding LIM protein 1",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.",".",".",".",".","."]
["ENSRNOG00000001700",688,57.88506483,2085,134.1289636,0.431562753,-1.212357739,{"v":8.31149e-95,"d":"8.31E-95"},{"v":1.1724E-93,"d":"1.17E-93"},"down","yes","Whrn","protein_coding","chr5:76828301-76912223:-","gi|149059586|gb|EDM10524.1|",4104,0,"CASK-interacting protein CIP98, isoform CRA_b [Rattus norvegicus]","gi|755506881|ref|XM_006538309.2|",3456,0,"PREDICTED: Mus musculus whirlin (Whrn), transcript variant X1, mRNA","Q810W9",1582,0,"Whirlin",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.","GO:0001895|retina homeostasis;GO:0007605|sensory perception of sound;GO:0010628|positive regulation of gene expression;GO:0021694|cerebellar Purkinje cell layer formation;GO:0045184|establishment of protein localization;GO:0050910|detection of mechanical stimulus involved in sensory perception of sound;GO:0050953|sensory perception of light stimulus;GO:0060088|auditory receptor cell stereocilium organization;GO:0060122|inner ear receptor cell stereocilium organization;GO:1990227|paranodal junction maintenance;","GO:0001917|photoreceptor inner segment;GO:0002141|stereocilia ankle link;GO:0002142|stereocilia ankle link complex;GO:0005737|cytoplasm;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0005929|cilium;GO:0016020|membrane;GO:0030426|growth cone;GO:0032391|photoreceptor connecting cilium;GO:0032420|stereocilium;GO:0032421|stereocilium bundle;GO:0032426|stereocilium tip;GO:0036064|ciliary basal body;GO:0043025|neuronal cell body;GO:0043198|dendritic shaft;GO:0044303|axon collateral;GO:0048471|perinuclear region of cytoplasm;GO:0097440|apical dendrite;GO:0098793|presynapse;GO:0098794|postsynapse;GO:1990075|periciliary membrane compartment;GO:1990696|USH2 complex;","GO:0019904|protein domain specific binding;GO:0042802|identical protein binding;","K21879","WHRN, USH2D; whirlin"]
["ENSRNOG00000067040",373,31.38245521,1424,91.60654398,0.342578749,-1.545492436,{"v":9.07124e-94,"d":"9.07E-94"},{"v":1.27298e-92,"d":"1.27E-92"},"down","yes","ENSRNOG00000067040","protein_coding","chr3:138654777-138675861:-","gi|889029083|ref|NP_001297574.1|",1844,0,"zinc finger protein 442 [Mus musculus]","gi|23274125|gb|BC023805.1|",841,0,"Mus musculus zinc finger protein 442, mRNA (cDNA clone MGC:38507 IMAGE:5352880), complete cds","Q8BZW4",540,{"v":1E-175,"d":"1.00E-175"},"Zinc finger protein 120",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000007907",1001,84.21940392,2675,172.0839221,0.489408905,-1.030887743,{"v":1.10882e-93,"d":"1.11E-93"},{"v":1.55202e-92,"d":"1.55E-92"},"down","yes","Tmem178a","protein_coding","chr6:14004630-14063549:-","gi|51948534|ref|NP_001004282.1|",1323,{"v":2e-177,"d":"2.00E-177"},"transmembrane protein 178A precursor [Rattus norvegicus]","gi|51260761|gb|BC079338.1|",1671,0,"Rattus norvegicus transmembrane protein 178, mRNA (cDNA clone MGC:94782 IMAGE:7106500), complete cds","Q68FV0",514,{"v":5e-179,"d":"5.00E-179"},"Transmembrane protein 178A",".",".",".",".","pfam13903","Claudin_2","PMP-22/EMP/MP20/Claudin tight junction. Members of this family are claudins, that form tight junctions between cells.","GO:0045671|negative regulation of osteoclast differentiation;GO:0051480|regulation of cytosolic calcium ion concentration;","GO:0005789|endoplasmic reticulum membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000033402",562,47.28402098,1820,117.0813975,0.403855967,-1.30808724,{"v":3.13923e-93,"d":"3.14E-93"},{"v":4.34927e-92,"d":"4.35E-92"},"down","yes","Gsta6","protein_coding","chr9:23744288-23801131:-","gi|66730521|ref|NP_001019532.1|",1180,{"v":3E-160,"d":"3.00E-160"},"glutathione S-transferase A6 [Rattus norvegicus]","gi|672064615|ref|XM_006244656.2|",1062,0,"PREDICTED: Rattus norvegicus similar to Glutathione S-transferase A1 (GTH1) (HA subunit 1) (GST-epsilon) (GSTA1-1) (GST class-alpha) (LOC501110), transcript variant X1, mRNA","Q6AXY0",459,{"v":9e-162,"d":"9.00E-162"},"Glutathione S-transferase A6",".",".",".",".","pfam00043","GST_C","Glutathione S-transferase, C-terminal domain. GST conjugates reduced glutathione to a variety of targets including S-crystallin from squid, the eukaryotic elongation factor 1-gamma, the HSP26 family of stress-related proteins and auxin-regulated proteins in plants. Stringent starvation proteins in Escherichia coli are also included in the alignment but are not known to have GST activity.     The glutathione molecule binds in a cleft between N and C-terminal domains. The catalytically important residues are proposed to reside in the N-terminal domain. In plants, GSTs are encoded by a large gene family (48 GST genes in Arabidopsis) and can be divided into the phi, tau, theta, zeta, and lambda classes.","GO:0006749|glutathione metabolic process;GO:0006805|xenobiotic metabolic process;GO:0009617|response to bacterium;GO:0035634|response to stilbenoid;","GO:0005829|cytosol;","GO:0004364|glutathione transferase activity;","K00799","GST, gst; glutathione S-transferase [EC:2.5.1.18]"]
["ENSRNOG00000018642",725,60.99806977,2143,137.860129,0.442463461,-1.176369775,{"v":6.18166E-93,"d":"6.18E-93"},{"v":8.52106e-92,"d":"8.52E-92"},"down","yes","Leng8","protein_coding","chr1:70040785-70052488:-","gi|564326125|ref|XP_006228280.1|",3413,0,"PREDICTED: leukocyte receptor cluster member 8 isoform X1 [Rattus norvegicus]","gi|564326124|ref|XM_006228218.1|",5122,0,"PREDICTED: Rattus norvegicus leukocyte receptor cluster (LRC) member 8 (Leng8), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam03399","SAC3_GANP","SAC3/GANP/Nin1/mts3/eIF-3 p25 family. This large family includes diverse proteins involved in large complexes. The alignment contains one highly conserved negatively charged residue and one highly conserved positively charged residue that are probably important for the function of these proteins. The family includes the yeast nuclear export factor Sac3, and mammalian GANP/MCM3-associated proteins, which facilitate the nuclear localisation of MCM3, a protein that associates with chromatin in the G1 phase of the cell-cycle. The 26S protease (or 26S proteasome) is responsible for degrading ubiquitin conjugates. It consists of 19S regulatory complexes associated with the ends of 20S proteasomes. The 19S regulatory complex is composed of about 20 different polypeptides and confers ATP-dependence and substrate specificity to the 26S enzyme. The conserved region occurs at the C-terminal of the Nin1-like regulatory subunit. This family includes several eukaryotic translation initiation factor 3 subunit 11 (eIF-3 p25) proteins. Eukaryotic initiation factor 3 (eIF3) is a multisubunit complex that is required for binding of mRNA to 40 S ribosomal subunits, stabilisation of ternary complex binding to 40 S subunits, and dissociation of 40 and 60 S subunits.",".","GO:0005634|nucleus;",".","K23802","LENG8, THP3; SAC3 family protein LENG8/THP3"]
["ENSRNOG00000046912",605,50.90183753,1896,121.9705108,0.417329051,-1.260742742,{"v":9.61062e-92,"d":"9.61E-92"},{"v":1.31478e-90,"d":"1.31E-90"},"down","yes","Nr1d2","protein_coding","chr15:7524257-7550553:+","gi|584277018|ref|NP_671743.2|",2855,0,"nuclear receptor subfamily 1 group D member 2 [Rattus norvegicus]","gi|584277017|ref|NM_147210.2|",4610,0,"Rattus norvegicus nuclear receptor subfamily 1, group D, member 2 (Nr1d2), mRNA","Q63504",1093,0,"Nuclear receptor subfamily 1 group D member 2",".",".",".",".","pfam00105","zf-C4","Zinc finger, C4 type (two domains). In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006355|regulation of transcription, DNA-templated;GO:0009755|hormone-mediated signaling pathway;GO:0019216|regulation of lipid metabolic process;GO:0030154|cell differentiation;GO:0030522|intracellular receptor signaling pathway;GO:0042752|regulation of circadian rhythm;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048512|circadian behavior;GO:0050727|regulation of inflammatory response;GO:0050728|negative regulation of inflammatory response;GO:0055088|lipid homeostasis;GO:0097009|energy homeostasis;GO:2001014|regulation of skeletal muscle cell differentiation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000987|proximal promoter sequence-specific DNA binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0004879|nuclear receptor activity;GO:0008270|zinc ion binding;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K08531","NR1D2; nuclear receptor subfamily 1 group D member 2"]
["ENSRNOG00000020526",542,45.60131561,1752,112.7069277,0.404600822,-1.305428844,{"v":1.53105e-89,"d":"1.53E-89"},{"v":2.02831e-88,"d":"2.03E-88"},"down","yes","Mau2","protein_coding","chr16:19383492-19408727:+","gi|564388528|ref|XP_006252940.1|",3250,0,"PREDICTED: MAU2 chromatid cohesion factor homolog isoform X2 [Rattus norvegicus]","gi|672079606|ref|XM_006252878.2|",1974,0,"PREDICTED: Rattus norvegicus MAU2 sister chromatid cohesion factor (Mau2), transcript variant X2, mRNA","Q9D2X5",1147,0,"MAU2 chromatid cohesion factor homolog",".",".",".",".","pfam10345","Cohesin_load","Cohesin loading factor. Cohesin_load is a common cohesin loading factor protein that is conserved in fungi. It is associated with the cohesin complex and is required in G1 for cohesin binding to chromosomes but dispensable in G2 when cohesion has been established. It is referred to as both Ssl3, in pombe, and Scc4, in S.cerevisiae. It complexes with Mis4.","GO:0034088|maintenance of mitotic sister chromatid cohesion;GO:0071921|cohesin loading;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0016604|nuclear body;GO:0032116|SMC loading complex;GO:0090694|Scc2-Scc4 cohesin loading complex;","GO:0003690|double-stranded DNA binding;GO:0047485|protein N-terminus binding;","K11266","MAU2; MAternally affected uncoordination"]
["ENSRNOG00000012436",143,12.03134342,846,54.4235507,0.221068697,-2.177433342,{"v":6.28477e-89,"d":"6.28E-89"},{"v":8.24569e-88,"d":"8.25E-88"},"down","yes","Adh6","protein_coding","chr2:226797303-226808892:+","gi|21070353|gb|AAM34269.1|AF508795_1",1809,0,"ADH-like protein [Rattus norvegicus]","gi|685156909|ref|NM_019286.4|",1806,0,"Rattus norvegicus alcohol dehydrogenase 1 (class I) (Adh1), mRNA","P06757",701,0,"Alcohol dehydrogenase 1","YPO1502",366,{"v":5e-120,"d":"5.00E-120"},"COG1062","pfam08240","ADH_N","Alcohol dehydrogenase GroES-like domain. This is the catalytic domain of alcohol dehydrogenases. Many of them contain an inserted zinc binding domain. This domain has a GroES-like structure.","GO:0001523|retinoid metabolic process;GO:0006068|ethanol catabolic process;GO:0006069|ethanol oxidation;GO:0008150|biological_process;GO:0031100|animal organ regeneration;GO:0032526|response to retinoic acid;GO:0032570|response to progesterone;GO:0033574|response to testosterone;GO:0042572|retinol metabolic process;GO:0042573|retinoic acid metabolic process;GO:0046186|acetaldehyde biosynthetic process;GO:0048149|behavioral response to ethanol;GO:0048545|response to steroid hormone;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0003674|molecular_function;GO:0004022|alcohol dehydrogenase (NAD) activity;GO:0004024|alcohol dehydrogenase activity, zinc-dependent;GO:0004745|retinol dehydrogenase activity;GO:0008270|zinc ion binding;GO:0016491|oxidoreductase activity;GO:0035276|ethanol binding;GO:0042802|identical protein binding;GO:0051287|NAD binding;GO:0097159|organic cyclic compound binding;","K13951","ADH1_7; alcohol dehydrogenase 1/7 [EC:1.1.1.1]K13951; K13952"]
["ENSRNOG00000007546",138,11.61066707,829,53.32993326,0.217713887,-2.19949466,{"v":2.97184e-88,"d":"2.97E-88"},{"v":3.8711e-87,"d":"3.87E-87"},"down","yes","Asns","protein_coding","chr4:35785237-35803423:-","gi|149064973|gb|EDM15049.1|",2902,0,"asparagine synthetase, isoform CRA_a [Rattus norvegicus]","gi|672048825|ref|XM_006236089.2|",2426,0,"PREDICTED: Rattus norvegicus asparagine synthetase (glutamine-hydrolyzing) (Asns), transcript variant X1, mRNA","P49088",1106,0,"Asparagine synthetase [glutamine-hydrolyzing]","L00396",330,{"v":9E-102,"d":"9.00E-102"},"COG0367","pfam00733","Asn_synthase","Asparagine synthase. This family is always found associated with pfam00310. Members of this family catalyse the conversion of aspartate to asparagine.","GO:0001889|liver development;GO:0006520|cellular amino acid metabolic process;GO:0006529|asparagine biosynthetic process;GO:0006541|glutamine metabolic process;GO:0009416|response to light stimulus;GO:0009612|response to mechanical stimulus;GO:0009636|response to toxic substance;GO:0031427|response to methotrexate;GO:0031667|response to nutrient levels;GO:0032354|response to follicle-stimulating hormone;GO:0032870|cellular response to hormone stimulus;GO:0042149|cellular response to glucose starvation;GO:0043066|negative regulation of apoptotic process;GO:0043200|response to amino acid;GO:0045931|positive regulation of mitotic cell cycle;GO:0070981|L-asparagine biosynthetic process;","GO:0005829|cytosol;","GO:0004066|asparagine synthase (glutamine-hydrolyzing) activity;GO:0005524|ATP binding;GO:0042802|identical protein binding;","K01953","asnB, ASNS; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4]"]
["ENSRNOG00000015421",654,55.02446569,1956,125.8303371,0.437290935,-1.193334655,{"v":6.64052e-87,"d":"6.64E-87"},{"v":8.5275e-86,"d":"8.53E-86"},"down","yes","Slc27a3","protein_coding","chr2:175853241-175857909:-","gi|157823505|ref|NP_001099909.1|",2962,0,"long-chain fatty acid transport protein 3 precursor [Rattus norvegicus]","gi|157823504|ref|NM_001106439.1|",2274,0,"Rattus norvegicus solute carrier family 27 member 3 (Slc27a3), mRNA","O88561",1068,0,"Long-chain fatty acid transport protein 3",".",".",".",".","pfam00501","AMP-binding","AMP-binding enzyme.","GO:0001676|long-chain fatty acid metabolic process;GO:0008150|biological_process;GO:0015908|fatty acid transport;GO:0015909|long-chain fatty acid transport;","GO:0005575|cellular_component;GO:0005739|mitochondrion;GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0004321|fatty-acyl-CoA synthase activity;GO:0004467|long-chain fatty acid-CoA ligase activity;GO:0005324|long-chain fatty acid transporter activity;GO:0031957|very long-chain fatty acid-CoA ligase activity;","K08772","SLC27A3, FATP3; solute carrier family 27 (fatty acid transporter), member 3 [EC:6.2.1.-]"]
["ENSRNOG00000002735",610,51.32251387,1867,120.1049281,0.427313972,-1.226631605,{"v":1.21054E-86,"d":"1.21E-86"},{"v":1.53802e-85,"d":"1.54E-85"},"down","yes","Dhx9","protein_coding","chr13:65602323-65639069:-","gi|157821633|ref|NP_001100654.1|",5670,0,"ATP-dependent RNA helicase A [Rattus norvegicus]","gi|672074381|ref|XM_006249995.2|",4332,0,"PREDICTED: Rattus norvegicus DEAH (Asp-Glu-Ala-His) box helicase 9 (Dhx9), transcript variant X1, mRNA","O70133",2160,0,"ATP-dependent RNA helicase A","SPBC15C4.05",328,{"v":1E-91,"d":"1.00E-91"},"COG1643","pfam04408","HA2","Helicase associated domain (HA2). This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.","GO:0000380|alternative mRNA splicing, via spliceosome;GO:0006353|DNA-templated transcription, termination;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007623|circadian rhythm;GO:0008150|biological_process;GO:0010501|RNA secondary structure unwinding;GO:0030423|targeting of mRNA for destruction involved in RNA interference;GO:0032508|DNA duplex unwinding;GO:0032727|positive regulation of interferon-alpha production;GO:0032728|positive regulation of interferon-beta production;GO:0032741|positive regulation of interleukin-18 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0034605|cellular response to heat;GO:0034622|cellular protein-containing complex assembly;GO:0039695|DNA-templated viral transcription;GO:0044806|G-quadruplex DNA unwinding;GO:0045089|positive regulation of innate immune response;GO:0045739|positive regulation of DNA repair;GO:0045740|positive regulation of DNA replication;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046833|positive regulation of RNA export from nucleus;GO:0048146|positive regulation of fibroblast proliferation;GO:0050434|positive regulation of viral transcription;GO:0050684|regulation of mRNA processing;GO:0050691|regulation of defense response to virus by host;GO:0050729|positive regulation of inflammatory response;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0060760|positive regulation of response to cytokine stimulus;GO:0070269|pyroptosis;GO:0070922|small RNA loading onto RISC;GO:0070934|CRD-mediated mRNA stabilization;GO:0071356|cellular response to tumor necrosis factor;GO:0071360|cellular response to exogenous dsRNA;GO:1903608|protein localization to cytoplasmic stress granule;GO:1904973|positive regulation of viral translation;GO:1905698|positive regulation of polysome binding;GO:2000373|positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity;GO:2000637|positive regulation of gene silencing by miRNA;GO:2000765|regulation of cytoplasmic translation;GO:2000767|positive regulation of cytoplasmic translation;","GO:0005575|cellular_component;GO:0005622|intracellular;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005726|perichromatin fibrils;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0005844|polysome;GO:0015629|actin cytoskeleton;GO:0016442|RISC complex;GO:0016604|nuclear body;GO:0032991|protein-containing complex;GO:0036464|cytoplasmic ribonucleoprotein granule;GO:0042788|polysomal ribosome;GO:0070578|RISC-loading complex;GO:0070937|CRD-mediated mRNA stability complex;GO:0097165|nuclear stress granule;GO:1990904|ribonucleoprotein complex;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000993|RNA polymerase II complex binding;GO:0001069|regulatory region RNA binding;GO:0003674|molecular_function;GO:0003678|DNA helicase activity;GO:0003688|DNA replication origin binding;GO:0003690|double-stranded DNA binding;GO:0003697|single-stranded DNA binding;GO:0003712|transcription coregulator activity;GO:0003713|transcription coactivator activity;GO:0003723|RNA binding;GO:0003724|RNA helicase activity;GO:0003725|double-stranded RNA binding;GO:0003727|single-stranded RNA binding;GO:0003729|mRNA binding;GO:0005524|ATP binding;GO:0031490|chromatin DNA binding;GO:0033679|3'-5' DNA/RNA helicase activity;GO:0034458|3'-5' RNA helicase activity;GO:0035197|siRNA binding;GO:0035613|RNA stem-loop binding;GO:0043138|3'-5' DNA helicase activity;GO:0045142|triplex DNA binding;GO:0047429|nucleoside-triphosphate diphosphatase activity;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;GO:0061676|importin-alpha family protein binding;GO:0070063|RNA polymerase binding;GO:1905172|RISC complex binding;GO:1905538|polysome binding;GO:1990518|single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity;GO:1990825|sequence-specific mRNA binding;GO:1990841|promoter-specific chromatin binding;","K13184","DHX9; ATP-dependent RNA helicase A [EC:3.6.4.13]"]
["ENSRNOG00000007970",807,67.8971618,2240,144.1001815,0.471180266,-1.085648979,{"v":1.55295e-85,"d":"1.55E-85"},{"v":1.95279e-84,"d":"1.95E-84"},"down","yes","Plxnc1","protein_coding","chr7:29390048-29543779:-","gi|9055376|ref|NP_061267.1|",7673,0,"plexin-C1 precursor [Mus musculus]","gi|672021707|ref|XM_006226039.2|",6256,0,"PREDICTED: Rattus norvegicus plexin C1 (Plxnc1), transcript variant X1, mRNA","Q9QZC2",2960,0,"Plexin-C1",".",".",".",".","pfam08337","Plexin_cytopl","Plexin cytoplasmic RasGAP domain. This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.","GO:0007162|negative regulation of cell adhesion;GO:0008360|regulation of cell shape;GO:0030334|regulation of cell migration;GO:0043087|regulation of GTPase activity;GO:0050772|positive regulation of axonogenesis;GO:1902287|semaphorin-plexin signaling pathway involved in axon guidance;","GO:0002116|semaphorin receptor complex;GO:0005887|integral component of plasma membrane;","GO:0017154|semaphorin receptor activity;","K06572","PLXNC, CD232; plexin C"]
["ENSRNOG00000063761",34,2.860599134,498,32.03655822,0.089291712,-3.485329916,{"v":2.56883e-85,"d":"2.57E-85"},{"v":3.21537E-84,"d":"3.22E-84"},"down","yes","ENSRNOG00000063761","lncRNA","chr3:164974985-164977741:+","gi|148682322|gb|EDL14269.1|",173,{"v":2e-11,"d":"2.00E-11"},"mCG146167, partial [Mus musculus]","gi|356995948|gb|AC240630.5|",2435,0,"Rattus norvegicus Y Chr BAC RNAEX-220B13 (Amplicon Express Rat SHR-Akr BAC library) complete sequence","P31789",53.5,7e-06,"Envelope glycoprotein",".",".",".",".","pfam07248","DUF1431","Protein of unknown function (DUF1431). This family contains a number of Drosophila melanogaster proteins of unknown function. These contain several conserved cysteine residues.",".",".",".",".","."]
["ENSRNOG00000008534",147,12.36788449,837,53.84457676,0.229696011,-2.122202293,{"v":2.85629e-85,"d":"2.86E-85"},{"v":3.56699e-84,"d":"3.57E-84"},"down","yes","Dusp15","protein_coding","chr3:141408498-141418999:-","gi|348605122|ref|NP_001102068.2|",1129,{"v":3e-143,"d":"3.00E-143"},"dual specificity protein phosphatase 15 isoform 1 [Rattus norvegicus]","gi|348605121|ref|NM_001108598.2|",3130,0,"Rattus norvegicus dual specificity phosphatase 15 (Dusp15), transcript variant 1, mRNA","B4F7B7",416,{"v":4E-136,"d":"4.00E-136"},"Dual specificity protein phosphatase 15","YIR026c",59.7,2E-8,"COG2453","pfam00782","DSPc","Dual specificity phosphatase, catalytic domain. Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a \"recognition\" region.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0016311|dephosphorylation;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0042127|regulation of cell proliferation;GO:0046330|positive regulation of JNK cascade;GO:0048713|regulation of oligodendrocyte differentiation;GO:0070374|positive regulation of ERK1 and ERK2 cascade;","GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0004725|protein tyrosine phosphatase activity;GO:0008138|protein tyrosine/serine/threonine phosphatase activity;GO:0016791|phosphatase activity;","K14165","K14165; atypical dual specificity phosphatase [EC:3.1.3.16 3.1.3.48]"]
["ENSRNOG00000020138",734,61.75528719,2095,134.772268,0.458219544,-1.125889101,{"v":7.32312e-85,"d":"7.32E-85"},{"v":9.08275e-84,"d":"9.08E-84"},"down","yes","Slc4a3","protein_coding","chr9:77037016-77049105:+","gi|149016209|gb|EDL75455.1|",4765,0,"solute carrier family 4, member 3, isoform CRA_a [Rattus norvegicus]","gi|8394312|ref|NM_017049.1|",3866,0,"Rattus norvegicus solute carrier family 4 member 3 (Slc4a3), mRNA","P16283",1825,0,"Anion exchange protein 3",".",".",".",".","pfam00955","HCO3_cotransp","HCO3- transporter family. This family contains Band 3 anion exchange proteins that exchange CL-/HCO3-. This family also includes cotransporters of Na+/HCO3-.","GO:0015698|inorganic anion transport;GO:0015701|bicarbonate transport;GO:0050801|ion homeostasis;GO:0051453|regulation of intracellular pH;GO:0055085|transmembrane transport;GO:0061337|cardiac conduction;GO:0098656|anion transmembrane transport;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0005452|inorganic anion exchanger activity;GO:0015106|bicarbonate transmembrane transporter activity;GO:0015301|anion:anion antiporter activity;GO:0019899|enzyme binding;GO:0022857|transmembrane transporter activity;","K13856","SLC4A3, AE3; solute carrier family 4 (anion exchanger), member 3"]
["ENSRNOG00000069423",657,55.2768715,1937,124.6080588,0.443605912,-1.172649504,{"v":9.03748e-84,"d":"9.04E-84"},{"v":1.10828E-82,"d":"1.11E-82"},"down","yes","ENSRNOG00000069423","protein_coding","chr8:2791853-2797967:+","gi|852749799|ref|XP_012872059.1|",906,{"v":6e-110,"d":"6.00E-110"},"PREDICTED: endogenous retrovirus group K member 8 Pol protein-like [Dipodomys ordii]","gi|153791782|ref|NG_006339.2|",1765,0,"Rattus norvegicus vomeronasal 2 receptor, pseudogene 55 (Vom2r-ps55) on chromosome 1","P04026",298,{"v":3e-91,"d":"3.00E-91"},"Intracisternal A-particle Pol-related polyprotein (Fragment)",".",".",".",".","pfam00665","rve","Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyses the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.",".",".",".",".","."]
["ENSRNOG00000011100",209,17.58427115,983,63.23682074,0.278070133,-1.8464793,{"v":1.86061e-83,"d":"1.86E-83"},{"v":2.27657E-82,"d":"2.28E-82"},"down","yes","AABR07040947.1","protein_coding","chr13:65941100-65942227:-","gi|585645604|ref|XP_006882199.1|",1080,{"v":3e-142,"d":"3.00E-142"},"PREDICTED: heterogeneous nuclear ribonucleoprotein A3-like [Elephantulus edwardii]","gi|831228654|ref|XM_012806181.1|",843,0,"PREDICTED: Otolemur garnettii heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3), mRNA","P51991",384,{"v":5e-130,"d":"5.00E-130"},"Heterogeneous nuclear ribonucleoprotein A3",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.",".",".",".",".","."]
["ENSRNOG00000066314",498,41.89936379,1613,103.7649968,0.403790923,-1.308319616,{"v":7.27613e-83,"d":"7.28E-83"},{"v":8.86296e-82,"d":"8.86E-82"},"down","yes","Bean1","protein_coding","chr19:739551-787537:-","gi|564321041|ref|XP_006222720.1|",844,{"v":4e-99,"d":"4.00E-99"},"PREDICTED: protein BEAN1 [Rattus norvegicus]","gi|672031012|ref|XM_008774191.1|",2480,0,"PREDICTED: Rattus norvegicus brain expressed, associated with NEDD4, 1 (Bean1), transcript variant X2, mRNA","Q9EQG5",286,{"v":1e-85,"d":"1.00E-85"},"Protein BEAN1",".",".",".",".","pfam12723","DUF3809","Protein of unknown function (DUF3809). This family of proteins is functionally uncharacterized. This family of proteins is found in Deinococci bacteria. Proteins in this family are typically between 117 and 157 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000055648",472,39.7118468,1558,100.2268227,0.396219752,-1.335627294,{"v":1.23572e-82,"d":"1.24E-82"},{"v":1.49187e-81,"d":"1.49E-81"},"down","yes","ENSRNOG00000055648","protein_coding","chrX:151154979-151180577:-","gi|471434814|ref|NP_001264201.1|",1283,{"v":2e-168,"d":"2.00E-168"},"HAUS augmin-like complex subunit 7 [Rattus norvegicus]","gi|471434813|ref|NM_001277272.1|",929,0,"Rattus norvegicus HAUS augmin-like complex, subunit 7 (Haus7), mRNA","Q8BKT8",474,{"v":2E-160,"d":"2.00E-160"},"HAUS augmin-like complex subunit 7",".",".",".",".","pfam04258","Peptidase_A22B","Signal peptide peptidase. The members of this family are membrane proteins. In some proteins this region is found associated with pfam02225. This family corresponds with Merops subfamily A22B, the type example of which is signal peptide peptidase. There is a sequence-similarity relationship with pfam01080.","GO:0007098|centrosome cycle;GO:0051225|spindle assembly;","GO:0005813|centrosome;GO:0070652|HAUS complex;GO:1990498|mitotic spindle microtubule;","GO:0031996|thioesterase binding;GO:0051011|microtubule minus-end binding;","K16590","HAUS7, UIP1; HAUS augmin-like complex subunit 7"]
["ENSRNOG00000014964",534,44.92823346,1683,108.2681275,0.414971927,-1.268914355,{"v":1.85112E-82,"d":"1.85E-82"},{"v":2.22496E-81,"d":"2.22E-81"},"down","yes","Hp","protein_coding","chr19:37539627-37544523:-","gi|60097941|ref|NP_036714.2|",1859,0,"haptoglobin precursor [Rattus norvegicus]","gi|298903469|emb|FQ209684.1|",1180,0,"Rattus norvegicus TL0ABA41YC01 mRNA sequence","P06866",720,0,"Haptoglobin","mlr3307",54.3,8e-07,"COG5640","pfam00089","Trypsin","Trypsin.","GO:0001666|response to hypoxia;GO:0001889|liver development;GO:0002526|acute inflammatory response;GO:0006508|proteolysis;GO:0006953|acute-phase response;GO:0007219|Notch signaling pathway;GO:0007283|spermatogenesis;GO:0007568|aging;GO:0009408|response to heat;GO:0009410|response to xenobiotic stimulus;GO:0009617|response to bacterium;GO:0010033|response to organic substance;GO:0010165|response to X-ray;GO:0010288|response to lead ion;GO:0010942|positive regulation of cell death;GO:0014070|response to organic cyclic compound;GO:0031100|animal organ regeneration;GO:0031638|zymogen activation;GO:0032026|response to magnesium ion;GO:0032496|response to lipopolysaccharide;GO:0033590|response to cobalamin;GO:0033591|response to L-ascorbic acid;GO:0042542|response to hydrogen peroxide;GO:0042594|response to starvation;GO:0042742|defense response to bacterium;GO:0051354|negative regulation of oxidoreductase activity;GO:0051384|response to glucocorticoid;GO:0051602|response to electrical stimulus;GO:0060416|response to growth hormone;GO:0098869|cellular oxidant detoxification;GO:2000296|negative regulation of hydrogen peroxide catabolic process;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0031838|haptoglobin-hemoglobin complex;GO:0072562|blood microparticle;","GO:0004252|serine-type endopeptidase activity;GO:0016209|antioxidant activity;GO:0030492|hemoglobin binding;GO:0042802|identical protein binding;","K16142","HP; haptoglobin"]
["ENSRNOG00000024089",692,58.2216059,1988,127.8889111,0.455251401,-1.135264639,{"v":1.1105e-81,"d":"1.11E-81"},{"v":1.32598E-80,"d":"1.33E-80"},"down","yes","Fndc3b","protein_coding","chr2:110312694-110547830:-","gi|300794741|ref|NP_001178633.1|",6142,0,"fibronectin type III domain-containing protein 3B [Rattus norvegicus]","gi|672042014|ref|XM_006232216.2|",5550,0,"PREDICTED: Rattus norvegicus fibronectin type III domain containing 3B (Fndc3b), transcript variant X2, mRNA","Q6NWW9",2263,0,"Fibronectin type III domain-containing protein 3B",".",".",".",".","pfam00041","fn3","Fibronectin type III domain.","GO:0016477|cell migration;GO:0034446|substrate adhesion-dependent cell spreading;GO:0045600|positive regulation of fat cell differentiation;GO:0045668|negative regulation of osteoblast differentiation;GO:0048146|positive regulation of fibroblast proliferation;GO:0060510|type II pneumocyte differentiation;","GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;",".","K24485","FNDC3; fibronectin type III domain-containing protein 3"]
["ENSRNOG00000027392",8,0.673082149,386,24.83154914,0.027105927,-5.205247863,{"v":2.34416e-81,"d":"2.34E-81"},{"v":2.79291e-80,"d":"2.79E-80"},"down","yes","Ccdc187","protein_coding","chr3:9070185-9126946:-","gi|755497662|ref|XP_011237420.1|",7423,0,"PREDICTED: uncharacterized protein LOC329366 isoform X3 [Mus musculus]","gi|755497667|ref|XM_011239121.1|",4170,0,"PREDICTED: Mus musculus RIKEN cDNA 4932418E24 gene (4932418E24Rik), transcript variant X6, mRNA","Q8C5V8",1281,0,"Coiled-coil domain-containing protein 187",".",".",".",".","pfam14817","HAUS5","HAUS augmin-like complex subunit 5. This family includes HAUS augmin-like complex subunit 5. The HAUS augmin-like complex contributes to mitotic spindle assembly, maintenance of chromosome integrity and completion of cytokinesis.","GO:0034453|microtubule anchoring;","GO:0005813|centrosome;","GO:0008017|microtubule binding;",".","."]
["ENSRNOG00000026171",770,64.78415686,2134,137.2811551,0.471908594,-1.083420651,{"v":2.59954e-81,"d":"2.60E-81"},{"v":3.09041e-80,"d":"3.09E-80"},"down","yes","Bbs4","protein_coding","chr8:59731912-59765607:-","gi|672061891|ref|XP_008764446.1|",2439,0,"PREDICTED: Bardet-Biedl syndrome 4 protein isoform X1 [Rattus norvegicus]","gi|672061890|ref|XM_008766224.1|",2639,0,"PREDICTED: Rattus norvegicus Bardet-Biedl syndrome 4 (Bbs4), transcript variant X1, mRNA","Q8C1Z7",884,0,"Bardet-Biedl syndrome 4 protein homolog","MA1362",89.4,{"v":7e-18,"d":"7.00E-18"},"COG0457","pfam13414","TPR_11","TPR repeat.","GO:0000226|microtubule cytoskeleton organization;GO:0000281|mitotic cytokinesis;GO:0001764|neuron migration;GO:0001843|neural tube closure;GO:0001895|retina homeostasis;GO:0003085|negative regulation of systemic arterial blood pressure;GO:0007098|centrosome cycle;GO:0007286|spermatid development;GO:0007608|sensory perception of smell;GO:0008104|protein localization;GO:0008150|biological_process;GO:0010629|negative regulation of gene expression;GO:0016358|dendrite development;GO:0019216|regulation of lipid metabolic process;GO:0021591|ventricular system development;GO:0021756|striatum development;GO:0021766|hippocampus development;GO:0021987|cerebral cortex development;GO:0030534|adult behavior;GO:0030837|negative regulation of actin filament polymerization;GO:0032465|regulation of cytokinesis;GO:0033210|leptin-mediated signaling pathway;GO:0033365|protein localization to organelle;GO:0034260|negative regulation of GTPase activity;GO:0034454|microtubule anchoring at centrosome;GO:0035176|social behavior;GO:0035845|photoreceptor cell outer segment organization;GO:0038108|negative regulation of appetite by leptin-mediated signaling pathway;GO:0040018|positive regulation of multicellular organism growth;GO:0044321|response to leptin;GO:0045444|fat cell differentiation;GO:0045494|photoreceptor cell maintenance;GO:0045724|positive regulation of cilium assembly;GO:0046548|retinal rod cell development;GO:0048854|brain morphogenesis;GO:0051457|maintenance of protein location in nucleus;GO:0051492|regulation of stress fiber assembly;GO:0060271|cilium assembly;GO:0060296|regulation of cilium beat frequency involved in ciliary motility;GO:0060324|face development;GO:0060613|fat pad development;GO:0061512|protein localization to cilium;GO:0071539|protein localization to centrosome;GO:1902855|regulation of non-motile cilium assembly;GO:1903546|protein localization to photoreceptor outer segment;GO:1905515|non-motile cilium assembly;","GO:0000242|pericentriolar material;GO:0001750|photoreceptor outer segment;GO:0001917|photoreceptor inner segment;GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005813|centrosome;GO:0005814|centriole;GO:0005829|cytosol;GO:0005929|cilium;GO:0016020|membrane;GO:0031514|motile cilium;GO:0032391|photoreceptor connecting cilium;GO:0034451|centriolar satellite;GO:0034464|BBSome;GO:0035869|ciliary transition zone;GO:0036064|ciliary basal body;GO:0060170|ciliary membrane;GO:0097730|non-motile cilium;","GO:0003674|molecular_function;GO:0030674|protein binding, bridging;GO:0034452|dynactin binding;GO:0043014|alpha-tubulin binding;GO:0048487|beta-tubulin binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;","K16531","BBS4; Bardet-Biedl syndrome 4 protein"]
["ENSRNOG00000047581",57,4.795710313,553,35.57473232,0.134806645,-2.891036481,{"v":3.28339e-80,"d":"3.28E-80"},{"v":3.85292E-79,"d":"3.85E-79"},"down","yes","AABR07066700.1","protein_coding","chr9:2849456-2916360:-","gi|672033554|ref|XP_008756458.1|",724,{"v":9e-112,"d":"9.00E-112"},"PREDICTED: uncharacterized protein LOC102557335 [Rattus norvegicus]","gi|672033553|ref|XM_008758236.1|",1256,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102557335 (LOC102557335), mRNA",".",".",".",".",".",".",".",".","pfam04822","Takusan","Takusan. This domain is named takusan, which is a Japanese word meaning 'many'. Members of this family regulate synaptic activity.",".",".",".",".","."]
["ENSRNOG00000027006",283,23.81028103,1134,72.9507169,0.326388582,-1.615337507,{"v":6.55594E-80,"d":"6.56E-80"},{"v":7.6437e-79,"d":"7.64E-79"},"down","yes","ENSRNOG00000027006","protein_coding","chr10:78217761-78218895:+","gi|585645604|ref|XP_006882199.1|",1080,{"v":1E-142,"d":"1.00E-142"},"PREDICTED: heterogeneous nuclear ribonucleoprotein A3-like [Elephantulus edwardii]","gi|672045838|ref|XM_008761912.1|",824,0,"PREDICTED: Rattus norvegicus heterogeneous nuclear ribonucleoprotein A3 (Hnrnpa3), transcript variant X2, mRNA","P51991",384,{"v":2e-130,"d":"2.00E-130"},"Heterogeneous nuclear ribonucleoprotein A3",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.",".","GO:0005634|nucleus;","GO:0003723|RNA binding;",".","."]
["ENSRNOG00000011923",367,30.87764359,1318,84.78751753,0.364176762,-1.457289227,{"v":7.54539e-80,"d":"7.55E-80"},{"v":8.77852e-79,"d":"8.78E-79"},"down","yes","Mgarp","protein_coding","chr2:135431283-135439612:-","gi|157818123|ref|NP_001103026.1|",744,{"v":8e-93,"d":"8.00E-93"},"protein MGARP [Rattus norvegicus]","gi|157818122|ref|NM_001109556.1|",1161,0,"Rattus norvegicus mitochondria-localized glutamic acid-rich protein (Mgarp), mRNA","Q8VI64",207,{"v":8e-62,"d":"8.00E-62"},"Protein MGARP",".",".",".",".","pfam14962","AIF-MLS","Mitochondria Localisation Sequence. This family contains a protein found in eukaryotes. Proteins in this family are typically between 240 and 613 amino acids in length. The family is found in association with pfam07992. This protein family is an N-terminal domain for the mitochondrial localisation sequence for an apoptosis-inducing factor. The protein is also known as Corneal endothelium-specific protein 1 or as Ovary-specific acidic protein. It is thought to be important for membrane function and is expressed in the ovary and corneal endothelium.","GO:0006626|protein targeting to mitochondrion;GO:0008089|anterograde axonal transport;GO:0008090|retrograde axonal transport;GO:0010822|positive regulation of mitochondrion organization;GO:0019896|axonal transport of mitochondrion;GO:0071383|cellular response to steroid hormone stimulus;GO:0071456|cellular response to hypoxia;GO:0097211|cellular response to gonadotropin-releasing hormone;","GO:0005739|mitochondrion;GO:0031307|integral component of mitochondrial outer membrane;GO:1904115|axon cytoplasm;",".",".","."]
["ENSRNOG00000009267",606,50.9859728,1805,116.1164409,0.439093486,-1.187399964,{"v":1.00835E-79,"d":"1.01E-79"},{"v":1.17064e-78,"d":"1.17E-78"},"down","yes","B3gnt2","protein_coding","chr14:96806664-96835273:-","gi|157822021|ref|NP_001100710.1|",2071,0,"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 [Rattus norvegicus]","gi|157822020|ref|NM_001107240.1|",2536,0,"Rattus norvegicus UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (B3gnt2), mRNA","Q9Z222",778,0,"N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2",".",".",".",".","pfam01762","Galactosyl_T","Galactosyltransferase. This family includes the galactosyltransferases UDP-galactose:2-acetamido-2-deoxy-D-glucose3beta-galactosyltransferase and UDP-Gal:beta-GlcNAc beta 1,3-galactosyltranferase. Specific galactosyltransferases transfer galactose to GlcNAc terminal chains in the synthesis of the lacto-series oligosaccharides types 1 and 2.","GO:0006486|protein glycosylation;GO:0007411|axon guidance;GO:0007608|sensory perception of smell;GO:0008150|biological_process;GO:0030311|poly-N-acetyllactosamine biosynthetic process;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0000139|Golgi membrane;GO:0005575|cellular_component;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0008194|UDP-glycosyltransferase activity;GO:0008532|N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity;GO:0016757|transferase activity, transferring glycosyl groups;","K00741","B3GNT2; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase [EC:2.4.1.149]"]
["ENSRNOG00000014320",91,7.656309447,649,41.75045438,0.183382662,-2.447070853,{"v":1.06877E-78,"d":"1.07E-78"},{"v":1.22254e-77,"d":"1.22E-77"},"down","yes","Inhba","protein_coding","chr17:49095920-49108982:-","gi|880891048|ref|XP_012970113.1|",2087,0,"PREDICTED: inhibin beta A chain [Mesocricetus auratus]","gi|672081983|ref|XM_008771716.1|",1544,0,"PREDICTED: Rattus norvegicus inhibin beta-A (Inhba), transcript variant X6, mRNA","P18331",806,0,"Inhibin beta A chain",".",".",".",".","pfam00019","TGF_beta","Transforming growth factor beta like domain.","GO:0000082|G1/S transition of mitotic cell cycle;GO:0001541|ovarian follicle development;GO:0001707|mesoderm formation;GO:0001942|hair follicle development;GO:0002244|hematopoietic progenitor cell differentiation;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008285|negative regulation of cell proliferation;GO:0008584|male gonad development;GO:0009410|response to xenobiotic stimulus;GO:0010628|positive regulation of gene expression;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0021773|striatal medium spiny neuron differentiation;GO:0030308|negative regulation of cell growth;GO:0032270|positive regulation of cellular protein metabolic process;GO:0032924|activin receptor signaling pathway;GO:0035987|endodermal cell differentiation;GO:0042476|odontogenesis;GO:0042541|hemoglobin biosynthetic process;GO:0042701|progesterone secretion;GO:0045648|positive regulation of erythrocyte differentiation;GO:0045786|negative regulation of cell cycle;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046880|regulation of follicle-stimulating hormone secretion;GO:0048333|mesodermal cell differentiation;GO:0051726|regulation of cell cycle;GO:0051799|negative regulation of hair follicle development;GO:0060021|roof of mouth development;GO:0060279|positive regulation of ovulation;GO:0060395|SMAD protein signal transduction;GO:0061029|eyelid development in camera-type eye;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0071397|cellular response to cholesterol;GO:0097154|GABAergic neuron differentiation;GO:0097191|extrinsic apoptotic signaling pathway;GO:2001241|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0043509|activin A complex;GO:0043512|inhibin A complex;GO:0048471|perinuclear region of cytoplasm;","GO:0005102|signaling receptor binding;GO:0005125|cytokine activity;GO:0005179|hormone activity;GO:0008083|growth factor activity;GO:0017046|peptide hormone binding;GO:0034711|inhibin binding;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;GO:0070699|type II activin receptor binding;","K04667","INHBA; inhibin beta A chain"]
["ENSRNOG00000019328",237,19.94005867,1021,65.68137739,0.303587706,-1.719814727,{"v":1.10318e-78,"d":"1.10E-78"},{"v":1.25926e-77,"d":"1.26E-77"},"down","yes","Phgdh","protein_coding","chr2:185906966-185935944:-","gi|13928850|ref|NP_113808.1|",2480,0,"D-3-phosphoglycerate dehydrogenase [Rattus norvegicus]","gi|564338012|ref|XM_006233010.1|",1546,0,"PREDICTED: Rattus norvegicus phosphoglycerate dehydrogenase (Phgdh), transcript variant X1, mRNA","O08651",959,0,"D-3-phosphoglycerate dehydrogenase","MJ1018",327,{"v":1e-102,"d":"1.00E-102"},"COG0111","pfam00389","2-Hacid_dh","D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. This family represents the largest portion of the catalytic domain of 2-hydroxyacid dehydrogenases as the NAD binding domain is inserted within the structural domain.","GO:0006541|glutamine metabolic process;GO:0006544|glycine metabolic process;GO:0006563|L-serine metabolic process;GO:0006564|L-serine biosynthetic process;GO:0006566|threonine metabolic process;GO:0009070|serine family amino acid biosynthetic process;GO:0009448|gamma-aminobutyric acid metabolic process;GO:0010468|regulation of gene expression;GO:0019530|taurine metabolic process;GO:0021510|spinal cord development;GO:0021782|glial cell development;GO:0021915|neural tube development;GO:0022008|neurogenesis;GO:0031175|neuron projection development;GO:0070314|G1 to G0 transition;","GO:0005575|cellular_component;","GO:0004617|phosphoglycerate dehydrogenase activity;GO:0051287|NAD binding;","K00058","serA, PHGDH; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]"]
["ENSRNOG00000063011",476,40.04838788,1536,98.81155305,0.405300662,-1.302935563,{"v":1.65269e-78,"d":"1.65E-78"},{"v":1.88256e-77,"d":"1.88E-77"},"down","yes","ENSRNOG00000063011","protein_coding","chr1:158035673-158044726:+","gi|148676020|gb|EDL07967.1|",1110,{"v":3E-134,"d":"3.00E-134"},"mCG1029965 [Mus musculus]","gi|46240867|gb|AC107531.8|",3250,0,"Rattus norvegicus 1 BAC CH230-158N3 (Children's Hospital Oakland Research Institute) complete sequence","P11369",214,{"v":3e-55,"d":"3.00E-55"},"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam12488","DUF3704","Protein of unknown function (DUF3704). This domain family is found in eukaryotes, and is approximately 30 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000047158",758,63.77453363,2077,133.6143201,0.477303133,-1.067022288,{"v":2.70163e-77,"d":"2.70E-77"},{"v":3.02674E-76,"d":"3.03E-76"},"down","yes","Selenbp1","protein_coding","chr2:182493978-182504594:+","gi|18266692|ref|NP_543168.1|",2528,0,"selenium-binding protein 1 [Rattus norvegicus]","gi|672043348|ref|XM_008761279.1|",1620,0,"PREDICTED: Rattus norvegicus selenium-binding protein 1 (LOC103689947), transcript variant X2, mRNA","Q8VIF7",978,0,"Methanethiol oxidase",".",".",".",".","pfam05694","SBP56","56kDa selenium binding protein (SBP56). This family consists of several eukaryotic selenium binding proteins as well as three sequences from archaea. The exact function of this protein is unknown although it is thought that SBP56 participates in late stages of intra-Golgi protein transport. The Lotus japonicus homologue of SBP56, LjSBP is thought to have more than one physiological role and can be implicated in controlling the oxidation/reduction status of target proteins, in vesicular Golgi transport.","GO:0015031|protein transport;","GO:0005634|nucleus;GO:0005829|cytosol;GO:0016020|membrane;","GO:0008430|selenium binding;GO:0018549|methanethiol oxidase activity;","K17285","SELENBP1; methanethiol oxidase [EC:1.8.3.4]"]
["ENSRNOG00000017766",324,27.25982704,1206,77.58250845,0.351365631,-1.508955014,{"v":5.15971e-77,"d":"5.16E-77"},{"v":5.76875e-76,"d":"5.77E-76"},"down","yes","Ca12","protein_coding","chr8:67274359-67330440:+","gi|564364325|ref|XP_006243372.1|",1817,0,"PREDICTED: carbonic anhydrase 12 isoform X1 [Rattus norvegicus]","gi|672062154|ref|XM_006243310.2|",3749,0,"PREDICTED: Rattus norvegicus carbonic anyhydrase 12 (Car12), transcript variant X1, mRNA","Q8CI85",678,0,"Carbonic anhydrase 12","BH0360",104,{"v":3E-23,"d":"3.00E-23"},"COG3338","pfam00194","Carb_anhydrase","Eukaryotic-type carbonic anhydrase.","GO:0006730|one-carbon metabolic process;GO:0055064|chloride ion homeostasis;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004089|carbonate dehydratase activity;GO:0008270|zinc ion binding;GO:0016836|hydro-lyase activity;","K01672","CA; carbonic anhydrase [EC:4.2.1.1]"]
["ENSRNOG00000008543",616,51.82732549,1802,115.9234496,0.447082326,-1.16138758,{"v":6.71787e-77,"d":"6.72E-77"},{"v":7.48011e-76,"d":"7.48E-76"},"down","yes","Pdlim2","protein_coding","chr15:45237477-45249242:-","gi|564386880|ref|XP_006252317.1|",1569,0,"PREDICTED: PDZ and LIM domain protein 2 isoform X2 [Rattus norvegicus]","gi|56090294|ref|NM_001007622.1|",1528,0,"Rattus norvegicus PDZ and LIM domain 2 (Pdlim2), mRNA","Q6AYD6",605,0,"PDZ and LIM domain protein 2",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.","GO:0007507|heart development;GO:0030036|actin cytoskeleton organization;GO:0061061|muscle structure development;","GO:0001725|stress fiber;GO:0005912|adherens junction;GO:0030018|Z disc;GO:0030864|cortical actin cytoskeleton;GO:0031941|filamentous actin;","GO:0003779|actin binding;GO:0005515|protein binding;GO:0031005|filamin binding;GO:0032036|myosin heavy chain binding;GO:0046872|metal ion binding;GO:0051371|muscle alpha-actinin binding;GO:0051393|alpha-actinin binding;","K23353","PDLIM1_2_3_4; PDZ and LIM domain protein 1/2/3/4"]
["ENSRNOG00000028063",692,58.2216059,1944,125.0583718,0.465555445,-1.102975101,{"v":2.28269E-76,"d":"2.28E-76"},{"v":2.53651e-75,"d":"2.54E-75"},"down","yes","Tmem38b","protein_coding","chr5:68460304-68496025:+","gi|62079117|ref|NP_001014213.1|",1510,0,"trimeric intracellular cation channel type B [Rattus norvegicus]","gi|62079116|ref|NM_001014191.1|",2680,0,"Rattus norvegicus transmembrane protein 38B (Tmem38b), mRNA","Q68FV1",582,0,"Trimeric intracellular cation channel type B",".",".",".",".","pfam05197","TRIC","TRIC channel. TRIC (trimeric intracellular cation) channels are differentially expressed in intracellular stores in animal cell types. TRIC subtypes contain three proposed transmembrane segments, and form homo-trimers with a bullet-like structure. Electrophysiological measurements with purified TRIC preparations identify a monovalent cation-selective channel.","GO:0001503|ossification;GO:0007029|endoplasmic reticulum organization;GO:0008654|phospholipid biosynthetic process;GO:0010881|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;GO:0014808|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0030282|bone mineralization;GO:0048286|lung alveolus development;GO:0051209|release of sequestered calcium ion into cytosol;GO:0060348|bone development;GO:0060487|lung epithelial cell differentiation;GO:0061033|secretion by lung epithelial cell involved in lung growth;GO:0070278|extracellular matrix constituent secretion;GO:0071313|cellular response to caffeine;GO:0071805|potassium ion transmembrane transport;GO:1903514|release of sequestered calcium ion into cytosol by endoplasmic reticulum;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0005267|potassium channel activity;GO:0042802|identical protein binding;","K24013","TMEM38, TRIC; trimeric intracellular cation channel"]
["ENSRNOG00000008374",429,36.09403025,1423,91.54221354,0.394288371,-1.342676934,{"v":3.09382e-76,"d":"3.09E-76"},{"v":3.43083E-75,"d":"3.43E-75"},"down","yes","Nipsnap1","protein_coding","chr14:79734209-79758098:+","gi|149047581|gb|EDM00251.1|",1411,0,"4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (C. elegans), isoform CRA_e [Rattus norvegicus]","gi|209969743|ref|NM_001100730.1|",1771,0,"Rattus norvegicus nipsnap homolog 1 (C. elegans) (Nipsnap1), mRNA","O55125",530,{"v":3e-177,"d":"3.00E-177"},"Protein NipSnap homolog 1",".",".",".",".","pfam07978","NIPSNAP","NIPSNAP. Members of this family include many hypothetical proteins. It also includes members of the NIPSNAP family which have putative roles in vesicular transport. This domain is often found in duplicate.","GO:0019233|sensory perception of pain;","GO:0005739|mitochondrion;GO:0016020|membrane;GO:0097060|synaptic membrane;","GO:0042165|neurotransmitter binding;",".","."]
["ENSRNOG00000039976",687,57.80092956,1933,124.350737,0.464821769,-1.105250459,{"v":3.40961e-76,"d":"3.41E-76"},{"v":3.77333e-75,"d":"3.77E-75"},"down","yes","Ptk7","protein_coding","chr9:14351202-14418494:+","gi|148691564|gb|EDL23511.1|",5501,0,"PTK7 protein tyrosine kinase 7, isoform CRA_a, partial [Mus musculus]","gi|271397552|ref|NM_175168.4|",3134,0,"Mus musculus PTK7 protein tyrosine kinase 7 (Ptk7), mRNA","Q8BKG3",2113,0,"Inactive tyrosine-protein kinase 7","BH2504_1",98.6,{"v":6e-21,"d":"6.00E-21"},"COG0515","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001736|establishment of planar polarity;GO:0001822|kidney development;GO:0001843|neural tube closure;GO:0003281|ventricular septum development;GO:0003401|axis elongation;GO:0007155|cell adhesion;GO:0007507|heart development;GO:0010976|positive regulation of neuron projection development;GO:0016477|cell migration;GO:0031532|actin cytoskeleton reorganization;GO:0042060|wound healing;GO:0045198|establishment of epithelial cell apical/basal polarity;GO:0060026|convergent extension;GO:0060484|lung-associated mesenchyme development;GO:0060828|regulation of canonical Wnt signaling pathway;GO:0060976|coronary vasculature development;GO:0071300|cellular response to retinoic acid;GO:0090103|cochlea morphogenesis;GO:0090179|planar cell polarity pathway involved in neural tube closure;GO:0090263|positive regulation of canonical Wnt signaling pathway;","GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0016020|membrane;","GO:0005524|ATP binding;GO:0050839|cell adhesion molecule binding;","K05127","PTK7, CCK4; PTK7 protein tyrosine kinase 7 [EC:2.7.10.1]"]
["ENSRNOG00000008965",778,65.45723901,2105,135.4155724,0.48338044,-1.048768998,{"v":3.45846e-76,"d":"3.46E-76"},{"v":3.81963E-75,"d":"3.82E-75"},"down","yes","Socs2","protein_coding","chr7:30008578-30043548:-","gi|149067130|gb|EDM16863.1|",1014,{"v":4e-133,"d":"4.00E-133"},"suppressor of cytokine signaling 2, isoform CRA_b [Rattus norvegicus]","gi|17158026|ref|NM_058208.1|",811,0,"Rattus norvegicus suppressor of cytokine signaling 2 (Socs2), mRNA","O88582",386,{"v":3E-131,"d":"3.00E-131"},"Suppressor of cytokine signaling 2",".",".",".",".","pfam00017","SH2","SH2 domain.","GO:0001558|regulation of cell growth;GO:0007568|aging;GO:0007595|lactation;GO:0016567|protein ubiquitination;GO:0032355|response to estradiol;GO:0032870|cellular response to hormone stimulus;GO:0035556|intracellular signal transduction;GO:0040014|regulation of multicellular organism growth;GO:0040015|negative regulation of multicellular organism growth;GO:0043434|response to peptide hormone;GO:0043551|regulation of phosphatidylinositol 3-kinase activity;GO:0045666|positive regulation of neuron differentiation;GO:0046426|negative regulation of JAK-STAT cascade;GO:0046854|phosphatidylinositol phosphorylation;GO:0060396|growth hormone receptor signaling pathway;GO:0060749|mammary gland alveolus development;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005942|phosphatidylinositol 3-kinase complex;","GO:0003674|molecular_function;GO:0005131|growth hormone receptor binding;GO:0005159|insulin-like growth factor receptor binding;GO:0008269|JAK pathway signal transduction adaptor activity;GO:0046935|1-phosphatidylinositol-3-kinase regulator activity;","K04695","SOCS2, CIS2; suppressor of cytokine signaling 2"]
["ENSRNOG00000009629",337,28.35358553,1221,78.54746502,0.36097391,-1.470033529,{"v":4.69085E-75,"d":"4.69E-75"},{"v":5.12871e-74,"d":"5.13E-74"},"down","yes","Car2","protein_coding","chr2:86741626-86756818:-","gi|9506445|ref|NP_062164.1|",1191,{"v":4e-157,"d":"4.00E-157"},"carbonic anhydrase 2 [Rattus norvegicus]","gi|298916112|emb|FQ213417.1|",723,0,"Rattus norvegicus TL0AAA47YP08 mRNA sequence","P27139",463,{"v":1e-158,"d":"1.00E-158"},"Carbonic anhydrase 2","all2929",114,{"v":3e-27,"d":"3.00E-27"},"COG3338","pfam00194","Carb_anhydrase","Eukaryotic-type carbonic anhydrase.","GO:0001822|kidney development;GO:0002009|morphogenesis of an epithelium;GO:0006730|one-carbon metabolic process;GO:0009268|response to pH;GO:0010033|response to organic substance;GO:0010043|response to zinc ion;GO:0015670|carbon dioxide transport;GO:0030316|osteoclast differentiation;GO:0030641|regulation of cellular pH;GO:0032230|positive regulation of synaptic transmission, GABAergic;GO:0032849|positive regulation of cellular pH reduction;GO:0038166|angiotensin-activated signaling pathway;GO:0042475|odontogenesis of dentin-containing tooth;GO:0043627|response to estrogen;GO:0044070|regulation of anion transport;GO:0045124|regulation of bone resorption;GO:0045672|positive regulation of osteoclast differentiation;GO:0045780|positive regulation of bone resorption;GO:0046903|secretion;GO:0048545|response to steroid hormone;GO:0051453|regulation of intracellular pH;GO:0071498|cellular response to fluid shear stress;GO:2001150|positive regulation of dipeptide transmembrane transport;GO:2001225|regulation of chloride transport;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005902|microvillus;GO:0016323|basolateral plasma membrane;GO:0030424|axon;GO:0043209|myelin sheath;GO:0045177|apical part of cell;","GO:0004064|arylesterase activity;GO:0004089|carbonate dehydratase activity;GO:0005515|protein binding;GO:0008270|zinc ion binding;GO:0016836|hydro-lyase activity;","K18245","CA2; carbonic anhydrase 2 [EC:4.2.1.1]"]
["ENSRNOG00000002093",206,17.33186534,915,58.86235094,0.294447386,-1.763918231,{"v":3.46638e-73,"d":"3.47E-73"},{"v":3.68631e-72,"d":"3.69E-72"},"down","yes","Tgfbr3","protein_coding","chr14:2489397-2663341:+","gi|8394446|ref|NP_058952.1|",4411,0,"transforming growth factor beta receptor type 3 precursor [Rattus norvegicus]","gi|8394445|ref|NM_017256.1|",3913,0,"Rattus norvegicus transforming growth factor, beta receptor III (Tgfbr3), mRNA","P26342",1703,0,"Transforming growth factor beta receptor type 3",".",".",".",".","pfam00100","Zona_pellucida","Zona pellucida-like domain.","GO:0001568|blood vessel development;GO:0001570|vasculogenesis;GO:0001649|osteoblast differentiation;GO:0001666|response to hypoxia;GO:0001701|in utero embryonic development;GO:0001824|blastocyst development;GO:0001837|epithelial to mesenchymal transition;GO:0001889|liver development;GO:0001974|blood vessel remodeling;GO:0003150|muscular septum morphogenesis;GO:0003151|outflow tract morphogenesis;GO:0003223|ventricular compact myocardium morphogenesis;GO:0006955|immune response;GO:0007165|signal transduction;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0007181|transforming growth factor beta receptor complex assembly;GO:0008284|positive regulation of cell proliferation;GO:0010629|negative regulation of gene expression;GO:0010633|negative regulation of epithelial cell migration;GO:0010719|negative regulation of epithelial to mesenchymal transition;GO:0016477|cell migration;GO:0017015|regulation of transforming growth factor beta receptor signaling pathway;GO:0030509|BMP signaling pathway;GO:0030511|positive regulation of transforming growth factor beta receptor signaling pathway;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030513|positive regulation of BMP signaling pathway;GO:0031100|animal organ regeneration;GO:0032354|response to follicle-stimulating hormone;GO:0032963|collagen metabolic process;GO:0034695|response to prostaglandin E;GO:0034699|response to luteinizing hormone;GO:0035556|intracellular signal transduction;GO:0043393|regulation of protein binding;GO:0050680|negative regulation of epithelial cell proliferation;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051271|negative regulation of cellular component movement;GO:0055010|ventricular cardiac muscle tissue morphogenesis;GO:0060021|roof of mouth development;GO:0060038|cardiac muscle cell proliferation;GO:0060045|positive regulation of cardiac muscle cell proliferation;GO:0060216|definitive hemopoiesis;GO:0060317|cardiac epithelial to mesenchymal transition;GO:0060318|definitive erythrocyte differentiation;GO:0060347|heart trabecula formation;GO:0060389|pathway-restricted SMAD protein phosphorylation;GO:0060412|ventricular septum morphogenesis;GO:0060939|epicardium-derived cardiac fibroblast cell development;GO:0060979|vasculogenesis involved in coronary vascular morphogenesis;GO:0061384|heart trabecula morphogenesis;GO:0062009|secondary palate development;GO:0065003|protein-containing complex assembly;GO:1902338|negative regulation of apoptotic process involved in morphogenesis;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0031012|extracellular matrix;GO:0034673|inhibin-betaglycan-ActRII complex;GO:0043235|receptor complex;GO:0062023|collagen-containing extracellular matrix;","GO:0005024|transforming growth factor beta-activated receptor activity;GO:0005114|type II transforming growth factor beta receptor binding;GO:0005160|transforming growth factor beta receptor binding;GO:0005515|protein binding;GO:0005539|glycosaminoglycan binding;GO:0008201|heparin binding;GO:0015026|coreceptor activity;GO:0017134|fibroblast growth factor binding;GO:0030165|PDZ domain binding;GO:0046332|SMAD binding;GO:0048185|activin binding;GO:0050431|transforming growth factor beta binding;GO:0070123|transforming growth factor beta receptor activity, type III;","K05843","TGFBR3; transforming growth factor, beta receptor III"]
["ENSRNOG00000001926",184,15.48088943,861,55.38850728,0.279496419,-1.839098297,{"v":6.06467e-73,"d":"6.06E-73"},{"v":6.42436e-72,"d":"6.42E-72"},"down","yes","Cldn1","protein_coding","chr11:74421569-74436724:+","gi|62296502|sp|P56745.2|CLD1_RAT",883,{"v":2E-107,"d":"2.00E-107"},"RecName: Full=Claudin-1","gi|61889098|ref|NM_031699.2|",3171,0,"Rattus norvegicus claudin 1 (Cldn1), mRNA","P56745",344,{"v":7e-109,"d":"7.00E-109"},"Claudin-1",".",".",".",".","pfam00822","PMP22_Claudin","PMP-22/EMP/MP20/Claudin family.","GO:0007155|cell adhesion;GO:0007568|aging;GO:0008065|establishment of blood-nerve barrier;GO:0009636|response to toxic substance;GO:0016338|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;GO:0030335|positive regulation of cell migration;GO:0032496|response to lipopolysaccharide;GO:0034331|cell junction maintenance;GO:0042538|hyperosmotic salinity response;GO:0045216|cell-cell junction organization;GO:0045471|response to ethanol;GO:0046718|viral entry into host cell;GO:0051259|protein complex oligomerization;GO:0060054|positive regulation of epithelial cell proliferation involved in wound healing;GO:0061436|establishment of skin barrier;GO:0061772|drug transport across blood-nerve barrier;GO:0070673|response to interleukin-18;GO:0070830|bicellular tight junction assembly;GO:0071284|cellular response to lead ion;GO:0071346|cellular response to interferon-gamma;GO:0071356|cellular response to tumor necrosis factor;GO:0071548|response to dexamethasone;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0090303|positive regulation of wound healing;GO:0090557|establishment of endothelial intestinal barrier;GO:0097421|liver regeneration;GO:1903348|positive regulation of bicellular tight junction assembly;GO:1903545|cellular response to butyrate;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005911|cell-cell junction;GO:0005923|bicellular tight junction;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0016328|lateral plasma membrane;GO:0030054|cell junction;GO:0032991|protein-containing complex;GO:0070160|tight junction;","GO:0001618|virus receptor activity;GO:0005198|structural molecule activity;GO:0042802|identical protein binding;","K06087","CLDN; claudin"]
["ENSRNOG00000016066",441,37.10365347,1418,91.22056135,0.406746603,-1.297797797,{"v":3.44802e-72,"d":"3.45E-72"},{"v":3.62432e-71,"d":"3.62E-71"},"down","yes","Bambi","protein_coding","chr17:54121255-54126060:-","gi|20806113|ref|NP_620782.1|",1167,{"v":1e-154,"d":"1.00E-154"},"BMP and activin membrane-bound inhibitor homolog precursor [Rattus norvegicus]","gi|47124146|gb|BC070516.1|",1060,0,"Rattus norvegicus BMP and activin membrane-bound inhibitor, homolog (Xenopus laevis), mRNA (cDNA clone MGC:91477 IMAGE:7100920), complete cds","Q91XN4",454,{"v":4e-156,"d":"4.00E-156"},"BMP and activin membrane-bound inhibitor homolog",".",".",".",".","pfam06211","BAMBI","BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain. This family consists of several eukaryotic BMP and activin membrane-bound inhibitor (BAMBI) proteins. Members of the transforming growth factor-beta (TGF-beta) superfamily, including TGF-beta, bone morphogenetic proteins (BMPs), activins and nodals, are vital for regulating growth and differentiation. BAMBI is related to TGF-beta-family type I receptors but lacks an intracellular kinase domain. BAMBI is co-expressed with the ventralising morphogen BMP4 during Xenopus embryogenesis and requires BMP signalling for its expression. The protein stably associates with TGF-beta-family receptors and inhibits BMP and activin as well as TGF-beta signalling.","GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0008284|positive regulation of cell proliferation;GO:0008360|regulation of cell shape;GO:0010718|positive regulation of epithelial to mesenchymal transition;GO:0016477|cell migration;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030514|negative regulation of BMP signaling pathway;GO:0032092|positive regulation of protein binding;GO:0045668|negative regulation of osteoblast differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0090263|positive regulation of canonical Wnt signaling pathway;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0005109|frizzled binding;","K10162","BAMBI; BMP and activin membrane-bound inhibitor"]
["ENSRNOG00000008146",210,17.66840642,918,59.05534225,0.29918388,-1.740895651,{"v":4.01164E-72,"d":"4.01E-72"},{"v":4.20862e-71,"d":"4.21E-71"},"down","yes","Tox2","protein_coding","chr3:151853294-151980749:+","gi|564344383|ref|XP_006235640.1|",1713,0,"PREDICTED: TOX high mobility group box family member 2 isoform X1 [Rattus norvegicus]","gi|672048111|ref|XM_006235578.2|",2238,0,"PREDICTED: Rattus norvegicus TOX high mobility group box family member 2 (Tox2), transcript variant X1, mRNA","Q76IQ7",555,0,"TOX high mobility group box family member 2",".",".",".",".","pfam00505","HMG_box","HMG (high mobility group) box.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0008585|female gonad development;GO:0034698|response to gonadotropin;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;GO:0005654|nucleoplasm;","GO:0003677|DNA binding;GO:0003713|transcription coactivator activity;GO:0031490|chromatin DNA binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;",".","."]
["ENSRNOG00000033663",529,44.50755711,1589,102.2210663,0.435404939,-1.199570323,{"v":1.59429e-71,"d":"1.59E-71"},{"v":1.65346e-70,"d":"1.65E-70"},"down","yes","P4ha2","protein_coding","chr10:38243139-38287314:+","gi|148701600|gb|EDL33547.1|",2957,0,"procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide, isoform CRA_e, partial [Mus musculus]","gi|672067340|ref|XM_008767691.1|",2195,0,"PREDICTED: Rattus norvegicus prolyl 4-hydroxylase, alpha polypeptide II (P4ha2), transcript variant X2, mRNA","Q60716",1031,0,"Prolyl 4-hydroxylase subunit alpha-2",".",".",".",".","pfam08336","P4Ha_N","Prolyl 4-Hydroxylase alpha-subunit, N-terminal region. The members of this family are eukaryotic proteins, and include all three isoforms of the prolyl 4-hydroxylase alpha subunit. This enzyme (EC:1.14.11.2) is important in the post-translational modification of collagen, as it catalyses the formation of 4-hydroxyproline. In vertebrates, the complete enzyme is an alpha2-beta2 tetramer; the beta-subunit is identical to protein disulphide isomerase. The function of the N-terminal region featured in this family does not seem to be known.","GO:0018401|peptidyl-proline hydroxylation to 4-hydroxy-L-proline;","GO:0005581|collagen trimer;GO:0005654|nucleoplasm;GO:0005783|endoplasmic reticulum;GO:0005788|endoplasmic reticulum lumen;GO:0005829|cytosol;GO:0016222|procollagen-proline 4-dioxygenase complex;GO:0043231|intracellular membrane-bounded organelle;","GO:0004656|procollagen-proline 4-dioxygenase activity;GO:0005506|iron ion binding;GO:0031418|L-ascorbic acid binding;","K00472","P4HA; prolyl 4-hydroxylase [EC:1.14.11.2]"]
["ENSRNOG00000058522",711,59.82017601,1931,124.2220761,0.481558334,-1.054217525,{"v":1.26607E-70,"d":"1.27E-70"},{"v":1.29578e-69,"d":"1.30E-69"},"down","yes","Fam214a","protein_coding","chr8:75695022-75772549:+","gi|157820039|ref|NP_001100308.1|",5438,0,"protein FAM214A [Rattus norvegicus]","gi|157820038|ref|NM_001106838.1|",4284,0,"Rattus norvegicus family with sequence similarity 214, member A (Fam214a), mRNA",".",".",".",".",".",".",".",".","pfam13915","DUF4210","Domain of unknown function (DUF4210). This short domain is found in fungi, plants and animals, and the proteins appear to be necessary for chromosome segregation during meiosis.",".",".",".",".","."]
["ENSRNOG00000000167",70,5.889468805,547,35.18874969,0.167367947,-2.578904831,{"v":1.41454E-70,"d":"1.41E-70"},{"v":1.44502E-69,"d":"1.45E-69"},"down","yes","ENSRNOG00000000167","protein_coding","chrX:19463171-19486519:+","gi|51980582|gb|AAH81857.1|",3064,0,"Aminolevulinate, delta-, synthase 2 [Rattus norvegicus]","gi|156255175|ref|NM_001102446.1|",1674,0,"Mus musculus aminolevulinic acid synthase 2, erythroid (Alas2), transcript variant 2, mRNA","Q63147",1183,0,"5-aminolevulinate synthase, erythroid-specific, mitochondrial","AGc4738",412,{"v":2E-136,"d":"2.00E-136"},"COG0156","pfam00155","Aminotran_1_2","Aminotransferase class I and II.","GO:0001666|response to hypoxia;GO:0006782|protoporphyrinogen IX biosynthetic process;GO:0006783|heme biosynthetic process;GO:0006879|cellular iron ion homeostasis;GO:0007595|lactation;GO:0009410|response to xenobiotic stimulus;GO:0010288|response to lead ion;GO:0030218|erythrocyte differentiation;GO:0032025|response to cobalt ion;GO:0042541|hemoglobin biosynthetic process;GO:0048821|erythrocyte development;GO:0060135|maternal process involved in female pregnancy;GO:0070542|response to fatty acid;GO:0097421|liver regeneration;GO:1901423|response to benzene;","GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0005759|mitochondrial matrix;","GO:0003870|5-aminolevulinate synthase activity;GO:0030170|pyridoxal phosphate binding;","K00643","E2.3.1.37, ALAS; 5-aminolevulinate synthase [EC:2.3.1.37]"]
["ENSRNOG00000010263",300,25.24058059,1109,71.34245595,0.353794669,-1.499015785,{"v":2.68471e-70,"d":"2.68E-70"},{"v":2.7323e-69,"d":"2.73E-69"},"down","yes","Cldn11","protein_coding","chr2:112207745-112221050:-","gi|148703035|gb|EDL34982.1|",1012,{"v":9e-131,"d":"9.00E-131"},"claudin 11, partial [Mus musculus]","gi|61889102|ref|NM_053457.2|",1845,0,"Rattus norvegicus claudin 11 (Cldn11), mRNA","Q60771",352,{"v":3e-116,"d":"3.00E-116"},"Claudin-11",".",".",".",".","pfam00822","PMP22_Claudin","PMP-22/EMP/MP20/Claudin family.","GO:0007155|cell adhesion;GO:0007283|spermatogenesis;GO:0008366|axon ensheathment;GO:0016338|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;GO:0070830|bicellular tight junction assembly;GO:0120192|tight junction assembly;","GO:0005811|lipid droplet;GO:0005883|neurofilament;GO:0005886|plasma membrane;GO:0005923|bicellular tight junction;GO:0016021|integral component of membrane;GO:0030054|cell junction;GO:0030424|axon;GO:0045178|basal part of cell;GO:0070160|tight junction;","GO:0005198|structural molecule activity;GO:0042802|identical protein binding;","K06087","CLDN; claudin"]
["ENSRNOG00000029949",13,1.093758492,350,22.51565336,0.048577693,-4.363562219,{"v":1.12515E-69,"d":"1.13E-69"},{"v":1.1345E-68,"d":"1.13E-68"},"down","yes","RGD1565462","protein_coding","chr6:123323629-123332433:+","gi|2507388|sp|P09006.3|SPA3N_RAT",2142,0,"RecName: Full=Serine protease inhibitor A3N; Short=Serpin A3N; AltName: Full=CPI-26; AltName: Full=Contrapsin-like protease inhibitor 6; AltName: Full=SPI-2.2; AltName: Full=Serine protease inhibitor 3; Short=SPI-3; Flags: Precursor","gi|298905524|emb|FQ209856.1|",3318,0,"Rattus norvegicus TL0ABA38YN22 mRNA sequence","P09006",826,0,"Serine protease inhibitor A3N","all0778",164,{"v":2e-42,"d":"2.00E-42"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0010951|negative regulation of endopeptidase activity;","GO:0005615|extracellular space;","GO:0004867|serine-type endopeptidase inhibitor activity;","K04525","SERPINA; serpin A"]
["ENSRNOG00000007830",572,48.12537367,1657,106.5955361,0.451476445,-1.147277376,{"v":1.59008e-69,"d":"1.59E-69"},{"v":1.60032E-68,"d":"1.60E-68"},"down","yes","Apold1","protein_coding","chr4:167818271-167825706:+","gi|50979282|ref|NP_001003403.1|",890,{"v":4e-108,"d":"4.00E-108"},"apolipoprotein L domain-containing protein 1 [Rattus norvegicus]","gi|50979281|ref|NM_001003403.1|",2883,0,"Rattus norvegicus apolipoprotein L domain containing 1 (Apold1), mRNA","Q6B959",345,{"v":7e-109,"d":"7.00E-109"},"Apolipoprotein L domain-containing protein 1",".",".",".",".","pfam10070","DUF2309","Uncharacterized protein conserved in bacteria (DUF2309). Members of this family of hypothetical bacterial proteins have no known function.","GO:0001525|angiogenesis;GO:0001666|response to hypoxia;GO:0006869|lipid transport;GO:0030154|cell differentiation;GO:0042118|endothelial cell activation;GO:0042157|lipoprotein metabolic process;GO:0045601|regulation of endothelial cell differentiation;","GO:0005576|extracellular region;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0008289|lipid binding;",".","."]
["ENSRNOG00000021748",773,65.03656266,2030,130.5907895,0.498017991,-1.005730233,{"v":9.08942e-69,"d":"9.09E-69"},{"v":9.11427e-68,"d":"9.11E-68"},"down","yes","ENSRNOG00000021748","protein_coding","chrX:60851962-60873687:-","gi|281604229|ref|NP_001164061.1|",3064,0,"ribosomal biogenesis protein LAS1L [Rattus norvegicus]","gi|281604228|ref|NM_001170590.1|",2171,0,"Rattus norvegicus LAS1-like, ribosome biogenesis factor (Las1l), mRNA","A2BE28",895,0,"Ribosomal biogenesis protein LAS1L",".",".",".",".","pfam04031","Las1","Las1-like. Las1 is an essential nuclear protein involved in cell morphogenesis and cell surface growth.","GO:0000460|maturation of 5.8S rRNA;GO:0000470|maturation of LSU-rRNA;GO:0090305|nucleic acid phosphodiester bond hydrolysis;","GO:0030687|preribosome, large subunit precursor;GO:0071339|MLL1 complex;GO:0090730|Las1 complex;","GO:0004519|endonuclease activity;","K16912","LAS1; ribosomal biogenesis protein LAS1"]
["ENSRNOG00000018413",457,38.44981777,1420,91.34922222,0.420910182,-1.248415685,{"v":3.72525e-68,"d":"3.73E-68"},{"v":3.70812E-67,"d":"3.71E-67"},"down","yes","Per3","protein_coding","chr5:161459533-161495607:-","gi|564354321|ref|XP_006239563.1|",5735,0,"PREDICTED: period circadian protein homolog 3 isoform X2 [Rattus norvegicus]","gi|672054644|ref|XM_006239501.2|",4941,0,"PREDICTED: Rattus norvegicus period circadian clock 3 (Per3), transcript variant X2, mRNA","Q8CJE2",2100,0,"Period circadian protein homolog 3",".",".",".",".","pfam12114","Period_C","Period protein 2/3C-terminal region. This domain is found in eukaryotes. This domain is typically between 164 to 200 amino acids in length. This domain is found associated with pfam08447.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0007623|circadian rhythm;GO:0032922|circadian regulation of gene expression;GO:0043153|entrainment of circadian clock by photoperiod;GO:0045187|regulation of circadian sleep/wake cycle, sleep;GO:0050821|protein stabilization;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0001222|transcription corepressor binding;GO:0019900|kinase binding;GO:0031625|ubiquitin protein ligase binding;","K21945","PER3; period circadian protein 3"]
["ENSRNOG00000008351",271,22.8006578,1031,66.32468177,0.343773346,-1.540470401,{"v":4.30078e-68,"d":"4.30E-68"},{"v":4.25765e-67,"d":"4.26E-67"},"down","yes","RGD1308117","protein_coding","chr15:45228615-45233254:-","gi|564386926|ref|XP_006252340.1|",1542,0,"PREDICTED: uncharacterized protein C8orf58 homolog isoform X1 [Rattus norvegicus]","gi|672078593|ref|XM_006252278.2|",1941,0,"PREDICTED: Rattus norvegicus similar to 9930012K11Rik protein (RGD1308117), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam15552","DUF4657","Domain of unknown function (DUF4657). This family of proteins is found in eukaryotes. Proteins in this family are typically between 305 and 370 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000045738",93,7.824579984,598,38.46960203,0.203396437,-2.297633688,{"v":1.35335e-67,"d":"1.35E-67"},{"v":1.32532e-66,"d":"1.33E-66"},"down","yes","Ak4","protein_coding","chr5:116039616-116098618:+","gi|564351830|ref|XP_006238507.1|",1185,{"v":2e-148,"d":"2.00E-148"},"PREDICTED: adenylate kinase 4, mitochondrial isoform X1 [Rattus norvegicus]","gi|672053113|ref|XM_006238445.2|",3755,0,"PREDICTED: Rattus norvegicus adenylate kinase 4 (Ak4), transcript variant X1, mRNA","Q9WUS0",455,{"v":7e-149,"d":"7.00E-149"},"Adenylate kinase 4, mitochondrial","BH0155",162,{"v":1e-43,"d":"1.00E-43"},"COG0563","pfam00406","ADK","Adenylate kinase.","GO:0001889|liver development;GO:0002082|regulation of oxidative phosphorylation;GO:0006165|nucleoside diphosphate phosphorylation;GO:0006172|ADP biosynthetic process;GO:0007420|brain development;GO:0009142|nucleoside triphosphate biosynthetic process;GO:0009410|response to xenobiotic stimulus;GO:0046033|AMP metabolic process;GO:0046034|ATP metabolic process;GO:0046039|GTP metabolic process;GO:0046940|nucleoside monophosphate phosphorylation;GO:0071456|cellular response to hypoxia;GO:2001169|regulation of ATP biosynthetic process;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005759|mitochondrial matrix;","GO:0003674|molecular_function;GO:0004017|adenylate kinase activity;GO:0004550|nucleoside diphosphate kinase activity;GO:0005524|ATP binding;GO:0005525|GTP binding;GO:0046899|nucleoside triphosphate adenylate kinase activity;","K00939","adk, AK; adenylate kinase [EC:2.7.4.3]"]
["ENSRNOG00000003616",455,38.28154723,1411,90.77024828,0.421741132,-1.245570363,{"v":1.68534e-67,"d":"1.69E-67"},{"v":1.64158e-66,"d":"1.64E-66"},"down","yes","Grem2","protein_coding","chr13:86778500-86871615:-","gi|157787016|ref|NP_001099444.1|",802,{"v":9e-96,"d":"9.00E-96"},"gremlin-2 precursor [Rattus norvegicus]","gi|157787015|ref|NM_001105974.1|",3716,0,"Rattus norvegicus gremlin 2 (Grem2), mRNA","O88273",312,{"v":9e-97,"d":"9.00E-97"},"Gremlin-2",".",".",".",".","pfam03045","DAN","DAN domain. This domain contains 9 conserved cysteines and is extracellular. Therefore the cysteines may form disulphide bridges. This family of proteins has been termed the DAN family after the first member to be reported. This family includes DAN, Cerberus and Gremlin. The gremlin protein is an antagonist of bone morphogenetic protein signaling. It is postulated that all members of this family antagonise different TGF beta pfam00019 ligands. Recent work shows that the DAN protein is not an efficient antagonist of BMP-2/4 class signals, we found that DAN was able to interact with GDF-5 in a frog embryo assay, suggesting that DAN may regulate signaling by the GDF-5/6/7 class of BMPs in vivo.","GO:0009887|animal organ morphogenesis;GO:0010172|embryonic body morphogenesis;GO:0019221|cytokine-mediated signaling pathway;GO:0030514|negative regulation of BMP signaling pathway;GO:0038098|sequestering of BMP from receptor via BMP binding;GO:0048263|determination of dorsal identity;GO:0060300|regulation of cytokine activity;","GO:0005615|extracellular space;","GO:0005125|cytokine activity;GO:0008201|heparin binding;GO:0036122|BMP binding;GO:0042802|identical protein binding;GO:0048018|receptor ligand activity;","K23318","GREM; gremlin"]
["ENSRNOG00000022066",714,60.07258181,1906,122.6138152,0.489933224,-1.029342965,{"v":3.96281e-67,"d":"3.96E-67"},{"v":3.84615e-66,"d":"3.85E-66"},"down","yes","Fam117b","protein_coding","chr9:61340249-61408483:+","gi|83582792|ref|NP_001032814.1|",1741,0,"protein FAM117B [Mus musculus]","gi|157818116|ref|NM_001108797.1|",4823,0,"Rattus norvegicus family with sequence similarity 117, member B (Fam117b), mRNA",".",".",".",".",".",".",".",".","pfam15388","FAM117","Protein Family FAM117. This protein family is a domain of unknown function found in eukaryotes. Proteins in this family are typically between 269 and 453 amino acids in length. There are two conserved sequence motifs: RRT and TQT.",".",".",".",".","."]
["ENSRNOG00000008054",420,35.33681283,1331,85.62381322,0.412698425,-1.276840164,{"v":3.17839e-66,"d":"3.18E-66"},{"v":3.02022e-65,"d":"3.02E-65"},"down","yes","Igsf9","protein_coding","chr13:84948619-84965607:+","gi|158635931|ref|NP_001100667.1|",4963,0,"protein turtle homolog A precursor [Rattus norvegicus]","gi|672074789|ref|XM_006250290.2|",3566,0,"PREDICTED: Rattus norvegicus immunoglobulin superfamily, member 9 (Igsf9), transcript variant X5, mRNA","P0C5H6",1916,0,"Protein turtle homolog A",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0016358|dendrite development;GO:0050807|regulation of synapse organization;GO:0098609|cell-cell adhesion;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0043005|neuron projection;GO:0060077|inhibitory synapse;","GO:0098632|cell-cell adhesion mediator activity;","K22655","IGSF9; immunoglobulin superfamily member 9"]
["ENSRNOG00000027491",464,39.03876465,1419,91.28489178,0.427658552,-1.225468704,{"v":3.32265E-66,"d":"3.32E-66"},{"v":3.1518e-65,"d":"3.15E-65"},"down","yes","Vldlr","protein_coding","chr1:224814377-224845920:+","gi|293597511|ref|NP_037287.2|",4306,0,"very low-density lipoprotein receptor precursor [Rattus norvegicus]","gi|293597510|ref|NM_013155.2|",3411,0,"Rattus norvegicus very low density lipoprotein receptor (Vldlr), mRNA","P98166",1665,0,"Very low-density lipoprotein receptor",".",".",".",".","pfam00057","Ldl_recept_a","Low-density lipoprotein receptor domain class A.","GO:0001666|response to hypoxia;GO:0006869|lipid transport;GO:0006898|receptor-mediated endocytosis;GO:0007166|cell surface receptor signaling pathway;GO:0007507|heart development;GO:0007584|response to nutrient;GO:0008203|cholesterol metabolic process;GO:0009410|response to xenobiotic stimulus;GO:0009725|response to hormone;GO:0021517|ventral spinal cord development;GO:0021987|cerebral cortex development;GO:0032496|response to lipopolysaccharide;GO:0032869|cellular response to insulin stimulus;GO:0034436|glycoprotein transport;GO:0034447|very-low-density lipoprotein particle clearance;GO:0038026|reelin-mediated signaling pathway;GO:0042149|cellular response to glucose starvation;GO:0045860|positive regulation of protein kinase activity;GO:0048813|dendrite morphogenesis;GO:0061098|positive regulation of protein tyrosine kinase activity;GO:0071222|cellular response to lipopolysaccharide;GO:0071347|cellular response to interleukin-1;GO:0071456|cellular response to hypoxia;GO:1900006|positive regulation of dendrite development;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0005905|clathrin-coated pit;GO:0009986|cell surface;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0034361|very-low-density lipoprotein particle;GO:0043235|receptor complex;GO:0045177|apical part of cell;GO:0048471|perinuclear region of cytoplasm;","GO:0005509|calcium ion binding;GO:0030229|very-low-density lipoprotein particle receptor activity;GO:0030296|protein tyrosine kinase activator activity;GO:0034185|apolipoprotein binding;GO:0034189|very-low-density lipoprotein particle binding;GO:0038024|cargo receptor activity;GO:0038025|reelin receptor activity;GO:0048306|calcium-dependent protein binding;","K20053","VLDLR; very low-density lipoprotein receptor"]
["ENSRNOG00000010078",93,7.824579984,590,37.95495853,0.206154355,-2.278203158,{"v":4.7051e-66,"d":"4.71E-66"},{"v":4.43996e-65,"d":"4.44E-65"},"down","yes","Spag1","protein_coding","chr7:67361477-67421368:+","gi|58865802|ref|NP_001012116.1|",4448,0,"sperm-associated antigen 1 [Rattus norvegicus]","gi|58865801|ref|NM_001012116.1|",3650,0,"Rattus norvegicus sperm associated antigen 1 (Spag1), mRNA","Q5U2X2",1717,0,"Sperm-associated antigen 1",".",".",".",".","pfam13877","RPAP3_C","Potential Monad-binding region of RPAP3. This domain is found at the C-terminus of RNA-polymerase II-associated proteins. These proteins bind to Monad and are involved in regulating apoptosis.   They contain TPR-repeats towards the N_terminus.","GO:0007338|single fertilization;GO:0070286|axonemal dynein complex assembly;","GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0005525|GTP binding;GO:0016787|hydrolase activity;","K19870","SPAG1; sperm-associated antigen 1"]
["ENSRNOG00000006670",313,26.33433909,1106,71.14946463,0.370127017,-1.433907649,{"v":9.76123e-66,"d":"9.76E-66"},{"v":9.13202e-65,"d":"9.13E-65"},"down","yes","Rai2","protein_coding","chrX:32948656-33011264:-","gi|157818399|ref|NP_001102786.1|",1291,{"v":4E-165,"d":"4.00E-165"},"retinoic acid-induced protein 2 [Rattus norvegicus]","gi|157818398|ref|NM_001109316.1|",2564,0,"Rattus norvegicus retinoic acid induced 2 (Rai2), mRNA",".",".",".",".",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.",".",".",".",".","."]
["ENSRNOG00000051531",323,27.17569177,1126,72.4360734,0.375167931,-1.414391583,{"v":1.45593E-65,"d":"1.46E-65"},{"v":1.35975e-64,"d":"1.36E-64"},"down","yes","Ctu2","protein_coding","chr19:50539352-50544623:+","gi|50926101|gb|AAH79393.1|",2630,0,"LOC292069 protein, partial [Rattus norvegicus]","gi|50926100|gb|BC079393.1|",1682,0,"Rattus norvegicus similar to RIKEN cDNA 2310061F22, mRNA (cDNA clone IMAGE:7111976), partial cds","Q3B7U4",976,0,"Cytoplasmic tRNA 2-thiolation protein 2",".",".",".",".","pfam10288","DUF2392","Protein of unknown function (DUF2392). This is a family of proteins conserved from plants to humans. The function is not known. It carries a characteristic GRG sequence motif.","GO:0002098|tRNA wobble uridine modification;GO:0002143|tRNA wobble position uridine thiolation;GO:0008150|biological_process;GO:0032447|protein urmylation;GO:0034227|tRNA thio-modification;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0032991|protein-containing complex;","GO:0000049|tRNA binding;GO:0003674|molecular_function;GO:0016779|nucleotidyltransferase activity;GO:0016783|sulfurtransferase activity;","K14169","CTU2, NCS2; cytoplasmic tRNA 2-thiolation protein 2"]
["ENSRNOG00000036667",469,39.459441,1422,91.4778831,0.431354986,-1.213052462,{"v":2.58932e-65,"d":"2.59E-65"},{"v":2.40588e-64,"d":"2.41E-64"},"down","yes","Hexd","protein_coding","chr10:106480194-106498799:+","gi|253735681|ref|NP_001136034.2|",2572,0,"hexosaminidase D [Rattus norvegicus]","gi|253735680|ref|NM_001142562.2|",1817,0,"Rattus norvegicus hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing (Hexdc), mRNA","Q3U4H6",955,0,"Hexosaminidase D",".",".",".",".","pfam00728","Glyco_hydro_20","Glycosyl hydrolase family 20, catalytic domain. This domain has a TIM barrel fold.","GO:0005975|carbohydrate metabolic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:1903561|extracellular vesicle;","GO:0004563|beta-N-acetylhexosaminidase activity;GO:0015929|hexosaminidase activity;GO:0102148|N-acetyl-beta-D-galactosaminidase activity;","K14459","HEX; hexosaminidase [EC:3.2.1.52]"]
["ENSRNOG00000020480",515,43.32966335,1511,97.2032921,0.445763332,-1.165650148,{"v":3.77404e-65,"d":"3.77E-65"},{"v":3.50069e-64,"d":"3.50E-64"},"down","yes","Fads1","protein_coding","chr1:206827765-206842734:+","gi|564332936|ref|XP_006231137.1|",2397,0,"PREDICTED: fatty acid desaturase 1 isoform X1 [Rattus norvegicus]","gi|672039785|ref|XM_006231075.2|",2896,0,"PREDICTED: Rattus norvegicus fatty acid desaturase 1 (Fads1), transcript variant X1, mRNA","Q920R3",862,0,"Fatty acid desaturase 1","YNL111c",62,{"v":5e-10,"d":"5.00E-10"},"COG5274","pfam00487","FA_desaturase","Fatty acid desaturase.","GO:0006629|lipid metabolic process;GO:0006636|unsaturated fatty acid biosynthetic process;GO:0007568|aging;GO:0007584|response to nutrient;GO:0009267|cellular response to starvation;GO:0009744|response to sucrose;GO:0010033|response to organic substance;GO:0014070|response to organic cyclic compound;GO:0019369|arachidonic acid metabolic process;GO:0032868|response to insulin;GO:0033189|response to vitamin A;GO:0035900|response to isolation stress;GO:0042759|long-chain fatty acid biosynthetic process;","GO:0005634|nucleus;GO:0005739|mitochondrion;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0016213|linoleoyl-CoA desaturase activity;GO:0016491|oxidoreductase activity;GO:0016717|oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water;","K10224","FADS1; acyl-CoA (8-3)-desaturase (Delta-5 desaturase) [EC:1.14.19.44]"]
["ENSRNOG00000009296",288,24.23095737,1048,67.41829922,0.359412172,-1.476288825,{"v":4.40877e-65,"d":"4.41E-65"},{"v":4.0825e-64,"d":"4.08E-64"},"down","yes","Snapc1","protein_coding","chr6:92684752-92707746:+","gi|157820321|ref|NP_001101503.1|",1941,0,"snRNA-activating protein complex subunit 1 [Rattus norvegicus]","gi|171847085|gb|BC161969.1|",1706,0,"Rattus norvegicus small nuclear RNA activating complex, polypeptide 1, mRNA (cDNA clone MGC:187778 IMAGE:9028949), complete cds","Q8K0S9",673,0,"snRNA-activating protein complex subunit 1",".",".",".",".","pfam09808","SNAPc_SNAP43","Small nuclear RNA activating complex (SNAPc), subunit SNAP43. Members of this family are part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. They bind to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Furthermore, they also recruit TBP and BRF2 to the U6 snRNA TATA box.","GO:0042795|snRNA transcription by RNA polymerase II;GO:0042796|snRNA transcription by RNA polymerase III;","GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0019185|snRNA-activating protein complex;","GO:0043565|sequence-specific DNA binding;","K15208","SNAPC1; snRNA-activating protein complex subunit 1"]
["ENSRNOG00000067370",126,10.60104385,672,43.23005446,0.24522393,-2.027828325,{"v":4.86784e-65,"d":"4.87E-65"},{"v":4.49994e-64,"d":"4.50E-64"},"down","yes","ENSRNOG00000067370","protein_coding","chr16:1627605-1636979:+","gi|564318467|ref|XP_006222143.1|",806,{"v":2E-100,"d":"2.00E-100"},"PREDICTED: uncharacterized protein LOC100911661 isoform X1 [Rattus norvegicus]","gi|672029006|ref|XM_006222081.2|",1071,0,"PREDICTED: Rattus norvegicus uncharacterized LOC100911661 (LOC100911661), transcript variant X1, mRNA","E9Q9R9",48.5,{"v":2e-11,"d":"2.00E-11"},"Disks large homolog 5",".",".",".",".","pfam12484","PE_PPE_C","Polymorphic PE/PPE proteins C terminal. This domain family is found in bacteria, and is approximately 90 amino acids in length. The family is found in association with pfam00823. There is a conserved SVP sequence motif. There is a single completely conserved residue W that may be functionally important. The proteins in this family are PE/PPE proteins implicated in immunostimulation and virulence.",".",".",".",".","."]
["ENSRNOG00000069240",245,20.61314082,946,60.85659452,0.338716633,-1.56184926,{"v":7.20955e-64,"d":"7.21E-64"},{"v":6.48841e-63,"d":"6.49E-63"},"down","yes","ENSRNOG00000069240","protein_coding","chr11:12193771-12199421:-","gi|852749799|ref|XP_012872059.1|",906,{"v":1E-108,"d":"1.00E-108"},"PREDICTED: endogenous retrovirus group K member 8 Pol protein-like [Dipodomys ordii]","gi|153791782|ref|NG_006339.2|",1903,0,"Rattus norvegicus vomeronasal 2 receptor, pseudogene 55 (Vom2r-ps55) on chromosome 1","P04026",299,{"v":3e-91,"d":"3.00E-91"},"Intracisternal A-particle Pol-related polyprotein (Fragment)",".",".",".",".","pfam00665","rve","Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyses the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.",".",".",".",".","."]
["ENSRNOG00000008936",134,11.274126,684,44.00201972,0.256218375,-1.96455415,{"v":1.48569e-63,"d":"1.49E-63"},{"v":1.33268E-62,"d":"1.33E-62"},"down","yes","Map3k6","protein_coding","chr5:145440346-145452212:+","gi|157816917|ref|NP_001101379.1|",5894,0,"mitogen-activated protein kinase kinase kinase 6 [Rattus norvegicus]","gi|157816916|ref|NM_001107909.1|",4339,0,"Rattus norvegicus mitogen-activated protein kinase kinase kinase 6 (Map3k6), mRNA","Q9WTR2",2156,0,"Mitogen-activated protein kinase kinase kinase 6",".",".",".",".","pfam13281","DUF4071","Domain of unknown function (DUF4071). This domain is found at the N-terminus of many serine-threonine kinase-like proteins.","GO:0000165|MAPK cascade;GO:0006468|protein phosphorylation;GO:0033554|cellular response to stress;",".","GO:0000287|magnesium ion binding;GO:0004672|protein kinase activity;GO:0004709|MAP kinase kinase kinase activity;GO:0005524|ATP binding;","K04425","MAP3K6, ASK2; mitogen-activated protein kinase kinase kinase 6 [EC:2.7.11.25]"]
["ENSRNOG00000028208",410,34.49546015,1282,82.47162175,0.418270666,-1.257491272,{"v":2.15371e-62,"d":"2.15E-62"},{"v":1.88531E-61,"d":"1.89E-61"},"down","yes","Mief2","protein_coding","chr10:45408082-45414144:+","gi|293340128|ref|XP_001077609.2|",2049,0,"PREDICTED: mitochondrial dynamics protein MID49 [Rattus norvegicus]","gi|672068143|ref|XM_006246545.2|",2650,0,"PREDICTED: Rattus norvegicus mitochondrial elongation factor 2 (Mief2), transcript variant X4, mRNA","Q5NCS9",716,0,"Mitochondrial dynamics protein MID49",".",".",".",".","pfam03281","Mab-21","Mab-21 protein. This family contains Mab-21 and Mab-21 like proteins. In C. elegans these proteins are required for several aspects of embryonic development.","GO:0003374|dynamin family protein polymerization involved in mitochondrial fission;GO:0007005|mitochondrion organization;GO:0008150|biological_process;GO:0010821|regulation of mitochondrion organization;GO:0090141|positive regulation of mitochondrial fission;GO:0090314|positive regulation of protein targeting to membrane;","GO:0005575|cellular_component;GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;","GO:0003674|molecular_function;","K23507","MIEF1_2; mitochondrial dynamics protein MID51/49"]
["ENSRNOG00000002579",246,20.69727609,935,60.1489597,0.344100317,-1.539098875,{"v":7.60579e-62,"d":"7.61E-62"},{"v":6.6154e-61,"d":"6.62E-61"},"down","yes","Parm1","protein_coding","chr14:16468459-16577314:-","gi|81885474|sp|Q6P9X9.1|PARM1_RAT",1006,{"v":1e-121,"d":"1.00E-121"},"RecName: Full=Prostate androgen-regulated mucin-like protein 1 homolog; Short=PARM-1; AltName: Full=Castration-induced prostatic apoptosis-related protein 1; Short=CIPAR-1; AltName: Full=Prostatic androgen-repressed message 1 protein; Flags: Precursor","gi|74148094|dbj|AK161172.1|",1247,0,"Mus musculus 0 day neonate head cDNA, RIKEN full-length enriched library, clone:4831433I04 product:Castration induced prostatic apoptosis related protein-1, (CIPAR- 1) homolog [Rattus norvegicus], full insert sequence","Q6P9X9",392,{"v":4e-123,"d":"4.00E-123"},"Prostate androgen-regulated mucin-like protein 1 homolog",".",".",".",".","pfam01858","RB_A","Retinoblastoma-associated protein A domain. This domain has the cyclin fold as predicted.","GO:0006915|apoptotic process;GO:0051973|positive regulation of telomerase activity;","GO:0000139|Golgi membrane;GO:0005654|nucleoplasm;GO:0005769|early endosome;GO:0005770|late endosome;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0010008|endosome membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;",".",".","."]
["ENSRNOG00000042826",111,9.33901482,614,39.49888905,0.236437405,-2.080469804,{"v":1.6007e-61,"d":"1.60E-61"},{"v":1.38783e-60,"d":"1.39E-60"},"down","yes","Zfp52","protein_coding","chr1:61335270-61363102:+","gi|62079051|ref|NP_001014180.1|",3913,0,"zinc finger protein 52 [Rattus norvegicus]","gi|62079050|ref|NM_001014158.1|",2385,0,"Rattus norvegicus zinc finger protein 52 (Zfp52), mRNA","Q8TAQ5",621,0,"Zinc finger protein 420",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;",".","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0046872|metal ion binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSRNOG00000005258",403,33.90651326,1261,81.12068255,0.417976183,-1.258507357,{"v":1.77825E-61,"d":"1.78E-61"},{"v":1.53687E-60,"d":"1.54E-60"},"down","yes","Myef2","protein_coding","chr3:112338241-112374181:-","gi|564342779|ref|XP_006234992.1|",2405,0,"PREDICTED: myelin expression factor 2 isoform X1 [Rattus norvegicus]","gi|564342778|ref|XM_006234930.1|",2682,0,"PREDICTED: Rattus norvegicus myelin expression factor 2 (Myef2), transcript variant X1, mRNA","Q8C854",911,0,"Myelin expression factor 2",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0014902|myotube differentiation;GO:0030182|neuron differentiation;GO:2000815|regulation of mRNA stability involved in response to oxidative stress;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0071014|post-mRNA release spliceosomal complex;GO:1990904|ribonucleoprotein complex;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003697|single-stranded DNA binding;GO:0003729|mRNA binding;","K24992","MYEF2; myelin expression factor 2"]
["ENSRNOG00000049351",24,2.019246448,352,22.64431424,0.089172338,-3.487259943,{"v":7.09081e-61,"d":"7.09E-61"},{"v":6.08006e-60,"d":"6.08E-60"},"down","yes","Nat8l","protein_coding","chr14:76756077-76763411:-","gi|134288912|ref|NP_001001985.3|",1097,{"v":2e-135,"d":"2.00E-135"},"N-acetylaspartate synthetase [Mus musculus]","gi|300794295|ref|NM_001191681.1|",3279,0,"Rattus norvegicus N-acetyltransferase 8-like (Nat8l), mRNA","D3ZVU9",425,{"v":4E-136,"d":"4.00E-136"},"N-acetylaspartate synthetase","YPO3444",56.6,5e-08,"COG0454","pfam00583","Acetyltransf_1","Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.","GO:0051586|positive regulation of dopamine uptake involved in synaptic transmission;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0030867|rough endoplasmic reticulum membrane;GO:0031966|mitochondrial membrane;","GO:0008080|N-acetyltransferase activity;GO:0017188|aspartate N-acetyltransferase activity;","K18309","NAT8L; aspartate N-acetyltransferase [EC:2.3.1.17]"]
["ENSRNOG00000045623",367,30.87764359,1182,76.03857793,0.406078657,-1.300168893,{"v":1.20092E-60,"d":"1.20E-60"},{"v":1.02489E-59,"d":"1.02E-59"},"down","yes","Capn10","protein_coding","chr9:93498478-93510494:+","gi|32469278|dbj|BAC79049.1|",3413,0,"calpain10 [Rattus norvegicus]","gi|77539057|ref|NM_031673.2|",2487,0,"Rattus norvegicus calpain 10 (Capn10), mRNA","Q9ES66",1320,0,"Calpain-10",".",".",".",".","pfam00648","Peptidase_C2","Calpain family cysteine protease.","GO:0000422|autophagy of mitochondrion;GO:0006508|proteolysis;GO:0007005|mitochondrion organization;GO:0007568|aging;GO:0009749|response to glucose;GO:0031532|actin cytoskeleton reorganization;GO:0031667|response to nutrient levels;GO:0032024|positive regulation of insulin secretion;GO:0032388|positive regulation of intracellular transport;GO:0032869|cellular response to insulin stimulus;GO:0043065|positive regulation of apoptotic process;GO:0046326|positive regulation of glucose import;GO:0097050|type B pancreatic cell apoptotic process;GO:2000676|positive regulation of type B pancreatic cell apoptotic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0005743|mitochondrial inner membrane;GO:0005758|mitochondrial intermembrane space;GO:0005759|mitochondrial matrix;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0005938|cell cortex;GO:0043231|intracellular membrane-bounded organelle;","GO:0000149|SNARE binding;GO:0004198|calcium-dependent cysteine-type endopeptidase activity;GO:0005515|protein binding;GO:0008092|cytoskeletal protein binding;","K08579","CAPN10; calpain-10 [EC:3.4.22.-]"]
["ENSRNOG00000008712",423,35.58921864,1293,83.17925657,0.427861706,-1.224783532,{"v":1.94605e-60,"d":"1.95E-60"},{"v":1.65303e-59,"d":"1.65E-59"},"down","yes","Tmem268","protein_coding","chr5:76977310-77001452:+","gi|157820875|ref|NP_001100131.1|",1627,0,"transmembrane protein C9orf91 homolog [Rattus norvegicus]","gi|157820874|ref|NM_001106661.1|",3795,0,"Rattus norvegicus similar to RIKEN cDNA 6330416G13 gene (RGD1304595), mRNA","Q8R239",606,0,"Transmembrane protein 268",".",".",".",".","pfam14800","DUF4481","Domain of unknown function (DUF4481).",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000007284",575,48.37777947,1585,101.9637445,0.474460601,-1.075639804,{"v":3.50654e-60,"d":"3.51E-60"},{"v":2.97392E-59,"d":"2.97E-59"},"down","yes","Slc2a1","protein_coding","chr5:132717196-132745416:+","gi|20301952|ref|NP_620182.1|",2389,0,"solute carrier family 2, facilitated glucose transporter member 1 [Rattus norvegicus]","gi|20301951|ref|NM_138827.1|",2533,0,"Rattus norvegicus solute carrier family 2 member 1 (Slc2a1), mRNA","P11167",924,0,"Solute carrier family 2, facilitated glucose transporter member 1","YBR241c",196,{"v":2e-53,"d":"2.00E-53"},"COG0477","pfam00083","Sugar_tr","Sugar (and other) transporter.","GO:0001666|response to hypoxia;GO:0006970|response to osmotic stress;GO:0007417|central nervous system development;GO:0007565|female pregnancy;GO:0015911|plasma membrane long-chain fatty acid transport;GO:0021987|cerebral cortex development;GO:0032868|response to insulin;GO:0042149|cellular response to glucose starvation;GO:0042908|xenobiotic transport;GO:0045494|photoreceptor cell maintenance;GO:0065003|protein-containing complex assembly;GO:0070837|dehydroascorbic acid transport;GO:0071260|cellular response to mechanical stimulus;GO:0071474|cellular hyperosmotic response;GO:0098708|glucose import across plasma membrane;GO:1904016|response to Thyroglobulin triiodothyronine;GO:1904659|glucose transmembrane transport;","GO:0001917|photoreceptor inner segment;GO:0001939|female pronucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005901|caveola;GO:0005911|cell-cell junction;GO:0014704|intercalated disc;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0030018|Z disc;GO:0030496|midbody;GO:0030864|cortical actin cytoskeleton;GO:0031982|vesicle;GO:0042383|sarcolemma;GO:0045121|membrane raft;GO:0045202|synapse;GO:0098793|presynapse;","GO:0005324|long-chain fatty acid transporter activity;GO:0005355|glucose transmembrane transporter activity;GO:0005515|protein binding;GO:0019900|kinase binding;GO:0033300|dehydroascorbic acid transmembrane transporter activity;GO:0042802|identical protein binding;GO:0042910|xenobiotic transmembrane transporter activity;GO:0043621|protein self-association;GO:0055056|D-glucose transmembrane transporter activity;","K07299","SLC2A1, GLUT1; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1"]
["ENSRNOG00000028319",239,20.10832921,907,58.34770743,0.344629294,-1.536882758,{"v":6.33115E-60,"d":"6.33E-60"},{"v":5.34452e-59,"d":"5.34E-59"},"down","yes","Cryz","protein_coding","chr2:243552119-243579758:+","gi|58865938|ref|NP_001012183.1|",1561,0,"quinone oxidoreductase [Rattus norvegicus]","gi|672044561|ref|XM_006233520.2|",1869,0,"PREDICTED: Rattus norvegicus crystallin, zeta (quinone reductase) (Cryz), transcript variant X1, mRNA","Q6AYT0",605,0,"Quinone oxidoreductase","BH0935",163,{"v":6e-44,"d":"6.00E-44"},"COG0604","pfam00107","ADH_zinc_N","Zinc-binding dehydrogenase.","GO:0008150|biological_process;GO:0042178|xenobiotic catabolic process;GO:0051289|protein homotetramerization;","GO:0005829|cytosol;","GO:0003730|mRNA 3'-UTR binding;GO:0003960|NADPH:quinone reductase activity;GO:0008270|zinc ion binding;GO:0042802|identical protein binding;GO:0070402|NADPH binding;","K00344","qor, CRYZ; NADPH:quinone reductase [EC:1.6.5.5]"]
["ENSRNOG00000047761",424,35.67335391,1289,82.92193482,0.430204071,-1.216906919,{"v":1.15329E-59,"d":"1.15E-59"},{"v":9.67567e-59,"d":"9.68E-59"},"down","yes","Zfp326","protein_coding","chr14:3941958-3980384:-","gi|672027704|ref|XP_008762849.1|",2303,0,"PREDICTED: DBIRD complex subunit ZNF326-like isoform X1, partial [Rattus norvegicus]","gi|269784643|ref|NM_018759.2|",1530,0,"Mus musculus zinc finger protein 326 (Zfp326), transcript variant 1, mRNA","O88291",845,0,"DBIRD complex subunit ZNF326",".",".",".",".","pfam04988","AKAP95","A-kinase anchoring protein 95 (AKAP95). A-kinase (or PKA)-anchoring protein AKAP95 is implicated in mitotic chromosome condensation by acting as a targeting molecule for the condensin complex. The protein contains two zinc fingers which are thought to mediate the binding of AKAP95 to DNA.","GO:0032784|regulation of DNA-templated transcription, elongation;GO:0043484|regulation of RNA splicing;GO:0045893|positive regulation of transcription, DNA-templated;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0016363|nuclear matrix;GO:0043231|intracellular membrane-bounded organelle;GO:0044609|DBIRD complex;","GO:0000993|RNA polymerase II complex binding;GO:0003677|DNA binding;GO:0008270|zinc ion binding;","K13204","ZNF326; zinc finger protein 326"]
["ENSRNOG00000010555",7,0.588946881,280,18.01252269,0.032696524,-4.93471892,{"v":8.84308e-59,"d":"8.84E-59"},{"v":7.3064e-58,"d":"7.31E-58"},"down","yes","Phyhip","protein_coding","chr15:45533974-45545221:+","gi|77046155|gb|AAH30494.2|",1778,0,"Phyhip protein, partial [Mus musculus]","gi|672078624|ref|XM_008770837.1|",2776,0,"PREDICTED: Rattus norvegicus phytanoyl-CoA 2-hydroxylase interacting protein (Phyhip), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam00041","fn3","Fibronectin type III domain.","GO:0008104|protein localization;","GO:0005737|cytoplasm;","GO:1990782|protein tyrosine kinase binding;",".","."]
["ENSRNOG00000043445",498,41.89936379,1421,91.41355266,0.458349583,-1.125479732,{"v":4.01672e-58,"d":"4.02E-58"},{"v":3.29374e-57,"d":"3.29E-57"},"down","yes","Them5","protein_coding","chr2:181980783-181986002:+","gi|157819023|ref|NP_001102028.1|",1261,{"v":2E-171,"d":"2.00E-171"},"acyl-coenzyme A thioesterase THEM5 [Rattus norvegicus]","gi|157819022|ref|NM_001108558.1|",1203,0,"Rattus norvegicus thioesterase superfamily member 5 (Them5), mRNA","Q9CQJ0",457,{"v":4E-160,"d":"4.00E-160"},"Acyl-coenzyme A thioesterase THEM5",".",".",".",".","pfam03061","4HBT","Thioesterase superfamily. This family contains a wide variety of enzymes, principally thioesterases. This family includes 4HBT (EC 3.1.2.23) which catalyses the final step in the biosynthesis of 4-hydroxybenzoate from 4-chlorobenzoate in the soil dwelling microbe Pseudomonas CBS-3. This family includes various cytosolic long-chain acyl-CoA thioester hydrolases. Long-chain acyl-CoA hydrolases hydrolyse palmitoyl-CoA to CoA and palmitate, they also catalyse the hydrolysis of other long chain fatty acyl-CoA thioesters.","GO:0035336|long-chain fatty-acyl-CoA metabolic process;GO:0035965|cardiolipin acyl-chain remodeling;","GO:0005759|mitochondrial matrix;","GO:0016290|palmitoyl-CoA hydrolase activity;","K22554","THEM5; acyl-coenzyme A thioesterase THEM5 [EC:3.1.2.2]"]
["ENSRNOG00000031287",131,11.02172019,641,41.23581088,0.267285157,-1.90354837,{"v":2.6861e-57,"d":"2.69E-57"},{"v":2.16352e-56,"d":"2.16E-56"},"down","yes","Cacna2d3","protein_coding","chr16:4098445-4912351:-","gi|6753236|ref|NP_033915.1|",5128,0,"voltage-dependent calcium channel subunit alpha-2/delta-3 precursor [Mus musculus]","gi|6753235|ref|NM_009785.1|",2509,0,"Mus musculus calcium channel, voltage-dependent, alpha2/delta subunit 3 (Cacna2d3), mRNA","Q9Z1L5",1972,0,"Voltage-dependent calcium channel subunit alpha-2/delta-3",".",".",".",".","pfam08399","VWA_N","VWA N-terminal. This domain is found at the N-terminus of proteins containing von Willebrand factor type A (VWA, pfam00092) and Cache (pfam02743) domains. It has been found in vertebrates, Drosophila and C. elegans but has not yet been identified in other eukaryotes. It is probably involved in the function of some voltage-dependent calcium channel subunits.","GO:0006816|calcium ion transport;GO:0034765|regulation of ion transmembrane transport;GO:0070588|calcium ion transmembrane transport;GO:1990314|cellular response to insulin-like growth factor stimulus;","GO:0005891|voltage-gated calcium channel complex;GO:0016021|integral component of membrane;","GO:0005244|voltage-gated ion channel activity;GO:0005245|voltage-gated calcium channel activity;GO:0005246|calcium channel regulator activity;GO:0005262|calcium channel activity;GO:0046872|metal ion binding;","K04860","CACNA2D3; voltage-dependent calcium channel alpha-2/delta-3"]
["ENSRNOG00000015796",409,34.41132488,1236,79.5124216,0.432779234,-1.20829682,{"v":1.14634e-56,"d":"1.15E-56"},{"v":9.12518e-56,"d":"9.13E-56"},"down","yes","Msh2","protein_coding","chr6:6813795-6872938:-","gi|149050462|gb|EDM02635.1|",4556,0,"mutS homolog 2 (E. coli) [Rattus norvegicus]","gi|171846746|gb|BC161846.1|",2799,0,"Rattus norvegicus mutS homolog 2 (E. coli), mRNA (cDNA clone MGC:187365 IMAGE:9029023), complete cds","P54275",1736,0,"DNA mismatch repair protein Msh2","YOL090w",650,0,"COG0249","pfam00488","MutS_V","MutS domain V. This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with pfam01624, pfam05188, pfam05192 and pfam05190. The mutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein. The aligned region corresponds with domain V of Thermus aquaticus MutS as characterized in, which contains a Walker A motif, and is structurally similar to the ATPase domain of ABC transporters.","GO:0001701|in utero embryonic development;GO:0002204|somatic recombination of immunoglobulin genes involved in immune response;GO:0006119|oxidative phosphorylation;GO:0006281|DNA repair;GO:0006298|mismatch repair;GO:0006301|postreplication repair;GO:0006302|double-strand break repair;GO:0006310|DNA recombination;GO:0006974|cellular response to DNA damage stimulus;GO:0007281|germ cell development;GO:0007283|spermatogenesis;GO:0008340|determination of adult lifespan;GO:0008584|male gonad development;GO:0008630|intrinsic apoptotic signaling pathway in response to DNA damage;GO:0009410|response to xenobiotic stimulus;GO:0010165|response to X-ray;GO:0010224|response to UV-B;GO:0014070|response to organic cyclic compound;GO:0016446|somatic hypermutation of immunoglobulin genes;GO:0016447|somatic recombination of immunoglobulin gene segments;GO:0019724|B cell mediated immunity;GO:0030183|B cell differentiation;GO:0031573|intra-S DNA damage checkpoint;GO:0042771|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0043200|response to amino acid;GO:0043524|negative regulation of neuron apoptotic process;GO:0043570|maintenance of DNA repeat elements;GO:0045190|isotype switching;GO:0045910|negative regulation of DNA recombination;GO:0048298|positive regulation of isotype switching to IgA isotypes;GO:0048304|positive regulation of isotype switching to IgG isotypes;GO:0051096|positive regulation of helicase activity;GO:0051726|regulation of cell cycle;GO:0071168|protein localization to chromatin;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005694|chromosome;GO:0032300|mismatch repair complex;GO:0032301|MutSalpha complex;GO:0032302|MutSbeta complex;","GO:0000287|magnesium ion binding;GO:0000400|four-way junction DNA binding;GO:0000406|double-strand/single-strand DNA junction binding;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003684|damaged DNA binding;GO:0003690|double-stranded DNA binding;GO:0003697|single-stranded DNA binding;GO:0005524|ATP binding;GO:0008022|protein C-terminus binding;GO:0008094|DNA-dependent ATPase activity;GO:0016887|ATPase activity;GO:0019237|centromeric DNA binding;GO:0019899|enzyme binding;GO:0019901|protein kinase binding;GO:0030983|mismatched DNA binding;GO:0032137|guanine/thymine mispair binding;GO:0032139|dinucleotide insertion or deletion binding;GO:0032142|single guanine insertion binding;GO:0032143|single thymine insertion binding;GO:0032181|dinucleotide repeat insertion binding;GO:0032357|oxidized purine DNA binding;GO:0032405|MutLalpha complex binding;GO:0042803|protein homodimerization activity;GO:0043531|ADP binding;","K08735","MSH2; DNA mismatch repair protein MSH2"]
["ENSRNOG00000007202",103,8.665932671,563,36.2180367,0.239271188,-2.06328141,{"v":5.52843E-56,"d":"5.53E-56"},{"v":4.35621e-55,"d":"4.36E-55"},"down","yes","Sema3d","protein_coding","chr4:22316779-22505930:-","gi|157277992|ref|NP_001098103.1|",4147,0,"semaphorin-3D [Rattus norvegicus]","gi|157277991|ref|NM_001104633.1|",4912,0,"Rattus norvegicus semaphorin 3D (Sema3d), mRNA","Q8BH34",1566,0,"Semaphorin-3D",".",".",".",".","pfam01403","Sema","Sema domain. The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and human plexin A-3.","GO:0001755|neural crest cell migration;GO:0007411|axon guidance;GO:0030335|positive regulation of cell migration;GO:0048843|negative regulation of axon extension involved in axon guidance;GO:0050919|negative chemotaxis;GO:0071526|semaphorin-plexin signaling pathway;","GO:0005615|extracellular space;GO:0005887|integral component of plasma membrane;","GO:0030215|semaphorin receptor binding;GO:0045499|chemorepellent activity;","K06840","SEMA3; semaphorin 3"]
["ENSRNOG00000046890",74,6.22600988,485,31.20026252,0.19954992,-2.325178397,{"v":6.18715e-56,"d":"6.19E-56"},{"v":4.86822e-55,"d":"4.87E-55"},"down","yes","Abca6","protein_coding","chr10:95142966-95211530:-","gi|564313554|ref|XP_006220946.1|",8247,0,"PREDICTED: ATP-binding cassette sub-family A member 6 isoform X1 [Rattus norvegicus]","gi|672025392|ref|XM_008775463.1|",5670,0,"PREDICTED: Rattus norvegicus ATP-binding cassette, subfamily A (ABC1), member 6 (Abca6), transcript variant X3, mRNA","Q8K441",2669,0,"ATP-binding cassette sub-family A member 6","PAB1703",155,{"v":7e-40,"d":"7.00E-40"},"COG1131","pfam00005","ABC_tran","ABC transporter. ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide or belong in different polypeptide chains.","GO:0006869|lipid transport;GO:0008150|biological_process;GO:0055085|transmembrane transport;","GO:0000139|Golgi membrane;GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0003674|molecular_function;GO:0005319|lipid transporter activity;GO:0005524|ATP binding;GO:0042626|ATPase activity, coupled to transmembrane movement of substances;","K05649","ABCA6; ATP-binding cassette, subfamily A (ABC1), member 6"]
["ENSRNOG00000008931",123,10.34863804,613,39.43455861,0.262425609,-1.930019584,{"v":7.32852e-56,"d":"7.33E-56"},{"v":5.74966e-55,"d":"5.75E-55"},"down","yes","Slc25a21","protein_coding","chr6:74203440-74702680:-","gi|19424330|ref|NP_598298.1|",1580,0,"mitochondrial 2-oxodicarboxylate carrier [Rattus norvegicus]","gi|58037555|ref|NM_133614.2|",2437,0,"Rattus norvegicus solute carrier family 25 member 21 (Slc25a21), mRNA","Q99JD3",613,0,"Mitochondrial 2-oxodicarboxylate carrier",".",".",".",".","pfam00153","Mito_carr","Mitochondrial carrier protein.","GO:1990550|mitochondrial alpha-ketoglutarate transmembrane transport;","GO:0005743|mitochondrial inner membrane;GO:0016021|integral component of membrane;","GO:0015139|alpha-ketoglutarate transmembrane transporter activity;","K15110","SLC25A21, ODC; solute carrier family 25 (mitochondrial 2-oxodicarboxylate transporter), member 21"]
["ENSRNOG00000009980",461,38.78635885,1329,85.49515235,0.453667346,-1.140293274,{"v":1.35269E-55,"d":"1.35E-55"},{"v":1.05676E-54,"d":"1.06E-54"},"down","yes","Plpp1","protein_coding","chr2:44438994-44501268:+","gi|149059350|gb|EDM10357.1|",1424,{"v":1e-177,"d":"1.00E-177"},"phosphatidic acid phosphatase 2a, isoform CRA_a [Rattus norvegicus]","gi|61889080|ref|NM_022538.2|",1118,0,"Rattus norvegicus phospholipid phosphatase 1 (Plpp1), mRNA","O08564",551,{"v":1e-178,"d":"1.00E-178"},"Phospholipid phosphatase 1","SPBC409.18",82.4,{"v":1e-15,"d":"1.00E-15"},"COG0671","pfam01569","PAP2","PAP2 superfamily. This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidizing halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.","GO:0006644|phospholipid metabolic process;GO:0006670|sphingosine metabolic process;GO:0006672|ceramide metabolic process;GO:0007165|signal transduction;GO:0009395|phospholipid catabolic process;GO:0046839|phospholipid dephosphorylation;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005901|caveola;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0045121|membrane raft;","GO:0000810|diacylglycerol diphosphate phosphatase activity;GO:0008195|phosphatidate phosphatase activity;GO:0042392|sphingosine-1-phosphate phosphatase activity;GO:0042577|lipid phosphatase activity;","K01080","PLPP1_2_3; phosphatidate phosphatase [EC:3.1.3.4]"]
["ENSRNOG00000017165",315,26.50260962,1038,66.77499484,0.396894222,-1.333173535,{"v":1.61663e-55,"d":"1.62E-55"},{"v":1.26108E-54,"d":"1.26E-54"},"down","yes","Akr1e2","protein_coding","chr17:65735943-65750441:+","gi|56605762|ref|NP_001008343.1|",1612,0,"1,5-anhydro-D-fructose reductase [Rattus norvegicus]","gi|56605761|ref|NM_001008342.1|",1340,0,"Rattus norvegicus aldo-keto reductase family 1, member E2 (Akr1e2), mRNA","Q5U1Y4",625,0,"1,5-anhydro-D-fructose reductase","slr0942",223,{"v":3e-67,"d":"3.00E-67"},"COG0656","pfam00248","Aldo_ket_red","Aldo/keto reductase family. This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.",".","GO:0005829|cytosol;","GO:0004032|alditol:NADP+ 1-oxidoreductase activity;GO:0016491|oxidoreductase activity;GO:0047834|D-threo-aldose 1-dehydrogenase activity;GO:0050571|1,5-anhydro-D-fructose reductase activity;","K13981","AKR1E2, AKR1CL2; 1,5-anhydro-D-fructose reductase [EC:1.1.1.263]"]
["ENSRNOG00000062871",306,25.74539221,1013,65.16673388,0.39506955,-1.339821441,{"v":1.25919E-54,"d":"1.26E-54"},{"v":9.67012e-54,"d":"9.67E-54"},"down","yes","ENSRNOG00000062871","lncRNA","chr14:4458688-4487530:+","gi|1791243|gb|AAB41224.1|",471,{"v":3e-101,"d":"3.00E-101"},"ORF2 [Rattus norvegicus]","gi|1213335|gb|U48828.1|RNU48828",3612,0,"Rattus norvegicus retroviral-like ovarian specific transcript 30-1 mRNA","P11369",183,{"v":1E-97,"d":"1.00E-97"},"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam02263","GBP","Guanylate-binding protein, N-terminal domain. Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.",".",".",".",".","."]
["ENSRNOG00000010566",234,19.68765286,859,55.2598464,0.356274115,-1.488940427,{"v":2.46398e-54,"d":"2.46E-54"},{"v":1.87899E-53,"d":"1.88E-53"},"down","yes","Cep44","protein_coding","chr16:33711559-33733225:+","gi|81295373|ref|NP_001032258.1|",1974,0,"centrosomal protein of 44 kDa [Rattus norvegicus]","gi|672080042|ref|XR_360442.2|",2172,0,"PREDICTED: Rattus norvegicus centrosomal protein 44 (Cep44), transcript variant X1, misc_RNA","Q3B7T8",764,0,"Centrosomal protein of 44 kDa",".",".",".",".","pfam15007","CEP44","Centrosomal spindle body, CEP44. CEP44 is a coiled coil domain found localized in the centrosome and spindle poles.","GO:0007098|centrosome cycle;GO:0007099|centriole replication;GO:0010457|centriole-centriole cohesion;","GO:0000922|spindle pole;GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0005814|centriole;GO:0030496|midbody;","GO:0008017|microtubule binding;","K16761","CEP44; centrosomal protein CEP44"]
["ENSRNOG00000015063",373,31.38245521,1146,73.72268216,0.425682494,-1.232150334,{"v":2.89443e-54,"d":"2.89E-54"},{"v":2.20416e-53,"d":"2.20E-53"},"down","yes","Dhodh","protein_coding","chr19:37558177-37591654:-","gi|56676360|ref|NP_001008553.1|",1775,0,"dihydroorotate dehydrogenase (quinone), mitochondrial precursor [Rattus norvegicus]","gi|672084936|ref|XR_361830.2|",1380,0,"PREDICTED: Rattus norvegicus dihydroorotate dehydrogenase (quinone) (Dhodh), transcript variant X3, misc_RNA","Q63707",688,0,"Dihydroorotate dehydrogenase (quinone), mitochondrial","SPAC57A10.12c",280,{"v":3e-81,"d":"3.00E-81"},"COG0167","pfam01180","DHO_dh","Dihydroorotate dehydrogenase.","GO:0006207|'de novo' pyrimidine nucleobase biosynthetic process;GO:0006225|UDP biosynthetic process;GO:0007565|female pregnancy;GO:0007595|lactation;GO:0009220|pyrimidine ribonucleotide biosynthetic process;GO:0009410|response to xenobiotic stimulus;GO:0014070|response to organic cyclic compound;GO:0031000|response to caffeine;GO:0042594|response to starvation;GO:0043065|positive regulation of apoptotic process;GO:0044205|'de novo' UMP biosynthetic process;GO:0090140|regulation of mitochondrial fission;GO:1903576|response to L-arginine;","GO:0005654|nucleoplasm;GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0005829|cytosol;GO:0016021|integral component of membrane;GO:0043025|neuronal cell body;","GO:0004151|dihydroorotase activity;GO:0004152|dihydroorotate dehydrogenase activity;GO:0010181|FMN binding;GO:0048038|quinone binding;GO:0048039|ubiquinone binding;","K00254","DHODH, pyrD; dihydroorotate dehydrogenase [EC:1.3.5.2]"]
["ENSRNOG00000007002",18,1.514434836,300,19.29913146,0.078471658,-3.671684514,{"v":3.68096e-54,"d":"3.68E-54"},{"v":2.7992e-53,"d":"2.80E-53"},"down","yes","Lif","protein_coding","chr14:79134574-79140482:+","gi|162287188|ref|NP_071532.2|",1079,{"v":9e-135,"d":"9.00E-135"},"leukemia inhibitory factor precursor [Rattus norvegicus]","gi|672076932|ref|XM_006251364.2|",2002,0,"PREDICTED: Rattus norvegicus leukemia inhibitory factor (Lif), transcript variant X1, mRNA","P17777",410,{"v":2E-132,"d":"2.00E-132"},"Leukemia inhibitory factor",".",".",".",".","pfam01291","LIF_OSM","LIF / OSM family.","GO:0001974|blood vessel remodeling;GO:0006955|immune response;GO:0007260|tyrosine phosphorylation of STAT protein;GO:0007566|embryo implantation;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0010628|positive regulation of gene expression;GO:0010976|positive regulation of neuron projection development;GO:0016525|negative regulation of angiogenesis;GO:0019827|stem cell population maintenance;GO:0030324|lung development;GO:0031100|animal organ regeneration;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0033141|positive regulation of peptidyl-serine phosphorylation of STAT protein;GO:0033630|positive regulation of cell adhesion mediated by integrin;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0043410|positive regulation of MAPK cascade;GO:0045595|regulation of cell differentiation;GO:0045651|positive regulation of macrophage differentiation;GO:0045835|negative regulation of meiotic nuclear division;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046697|decidualization;GO:0046888|negative regulation of hormone secretion;GO:0048286|lung alveolus development;GO:0048644|muscle organ morphogenesis;GO:0048666|neuron development;GO:0048708|astrocyte differentiation;GO:0048711|positive regulation of astrocyte differentiation;GO:0048861|leukemia inhibitory factor signaling pathway;GO:0048863|stem cell differentiation;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0051461|positive regulation of corticotropin secretion;GO:0060041|retina development in camera-type eye;GO:0060135|maternal process involved in female pregnancy;GO:0060290|transdifferentiation;GO:0060426|lung vasculature development;GO:0060463|lung lobe morphogenesis;GO:0060707|trophoblast giant cell differentiation;GO:0060708|spongiotrophoblast differentiation;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0072108|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0072307|regulation of metanephric nephron tubule epithelial cell differentiation;GO:1900182|positive regulation of protein localization to nucleus;GO:1901676|positive regulation of histone H3-K27 acetylation;GO:1903025|regulation of RNA polymerase II regulatory region sequence-specific DNA binding;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005829|cytosol;","GO:0005102|signaling receptor binding;GO:0005125|cytokine activity;GO:0005146|leukemia inhibitory factor receptor binding;GO:0008083|growth factor activity;","K05419","LIF; leukemia inhibitory factor"]
["ENSRNOG00000009564",474,39.88011734,1337,86.00979585,0.46366948,-1.108831326,{"v":1.55376e-53,"d":"1.55E-53"},{"v":1.16528e-52,"d":"1.17E-52"},"down","yes","Prr15","protein_coding","chr4:83431758-83437436:+","gi|149033319|gb|EDL88120.1|",859,{"v":6E-103,"d":"6.00E-103"},"similar to RIKEN cDNA E130201N16 (predicted), isoform CRA_a [Rattus norvegicus]","gi|354799084|gb|JN963585.1|",1559,0,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Prr15:tm1e(KOMP)Wtsi; transgenic","Q9D1T5",204,{"v":8e-59,"d":"8.00E-59"},"Proline-rich protein 15",".",".",".",".","pfam15321","ATAD4","ATPase family AAA domain containing 4. ATAD4 is a family of proteins is found in eukaryotes. The family is also known as PRR15L, or proline-rich 15-like. ATAD4 is expressed almost exclusively in post-mitotic cells both during foetal development and in adult tissues, such as the intestinal epithelium and the testis. Its expression in mouse and human gastrointestinal tumors is linked, directly or indirectly, to the disruption of the Wnt signaling pathway.",".",".",".",".","."]
["ENSRNOG00000011039",410,34.49546015,1213,78.03282152,0.442063474,-1.177674561,{"v":1.69431E-53,"d":"1.69E-53"},{"v":1.26721e-52,"d":"1.27E-52"},"down","yes","Gch1","protein_coding","chr15:20402527-20437698:-","gi|13242245|ref|NP_077332.1|",1290,{"v":2e-168,"d":"2.00E-168"},"GTP cyclohydrolase 1 precursor [Rattus norvegicus]","gi|13542897|gb|BC005643.1|",1365,0,"Mus musculus GTP cyclohydrolase 1, mRNA (cDNA clone MGC:12095 IMAGE:3709238), complete cds","P22288",501,{"v":5e-170,"d":"5.00E-170"},"GTP cyclohydrolase 1","alr5287",260,{"v":7e-79,"d":"7.00E-79"},"COG0302","pfam01227","GTP_cyclohydroI","GTP cyclohydrolase I. This family includes GTP cyclohydrolase enzymes and a family of related bacterial proteins.","GO:0006729|tetrahydrobiopterin biosynthetic process;GO:0008217|regulation of blood pressure;GO:0010460|positive regulation of heart rate;GO:0014916|regulation of lung blood pressure;GO:0032496|response to lipopolysaccharide;GO:0034341|response to interferon-gamma;GO:0034612|response to tumor necrosis factor;GO:0035998|7,8-dihydroneopterin 3'-triphosphate biosynthetic process;GO:0042311|vasodilation;GO:0042416|dopamine biosynthetic process;GO:0042559|pteridine-containing compound biosynthetic process;GO:0045776|negative regulation of blood pressure;GO:0046654|tetrahydrofolate biosynthetic process;GO:0048265|response to pain;GO:0050884|neuromuscular process controlling posture;GO:0051000|positive regulation of nitric-oxide synthase activity;GO:0051066|dihydrobiopterin metabolic process;GO:0065003|protein-containing complex assembly;GO:2000121|regulation of removal of superoxide radicals;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0031410|cytoplasmic vesicle;GO:0031965|nuclear membrane;GO:0032991|protein-containing complex;","GO:0003924|GTPase activity;GO:0003934|GTP cyclohydrolase I activity;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0005525|GTP binding;GO:0008270|zinc ion binding;GO:0030742|GTP-dependent protein binding;GO:0031369|translation initiation factor binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0044877|protein-containing complex binding;GO:0051019|mitogen-activated protein kinase binding;","K01495","GCH1, folE; GTP cyclohydrolase IA [EC:3.5.4.16]"]
["ENSRNOG00000015991",595,50.06048484,1563,100.5484749,0.497874134,-1.00614703,{"v":2.11148e-53,"d":"2.11E-53"},{"v":1.57705e-52,"d":"1.58E-52"},"down","yes","Npr2","protein_coding","chr5:57883171-57901580:+","gi|16758694|ref|NP_446290.1|",4980,0,"atrial natriuretic peptide receptor 2 precursor [Rattus norvegicus]","gi|16758693|ref|NM_053838.1|",1962,0,"Rattus norvegicus natriuretic peptide receptor 2 (Npr2), mRNA","P16067",1922,0,"Atrial natriuretic peptide receptor 2","all0661",186,{"v":3E-49,"d":"3.00E-49"},"COG2114","pfam00211","Guanylate_cyc","Adenylate and Guanylate cyclase catalytic domain.","GO:0001503|ossification;GO:0006182|cGMP biosynthetic process;GO:0006468|protein phosphorylation;GO:0007165|signal transduction;GO:0007168|receptor guanylyl cyclase signaling pathway;GO:0010753|positive regulation of cGMP-mediated signaling;GO:0019934|cGMP-mediated signaling;GO:0022414|reproductive process;GO:0051447|negative regulation of meiotic cell cycle;GO:0060348|bone development;GO:0097011|cellular response to granulocyte macrophage colony-stimulating factor stimulus;GO:1900194|negative regulation of oocyte maturation;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;","GO:0001653|peptide receptor activity;GO:0004383|guanylate cyclase activity;GO:0004672|protein kinase activity;GO:0005524|ATP binding;GO:0005525|GTP binding;GO:0016941|natriuretic peptide receptor activity;GO:0017046|peptide hormone binding;GO:0042562|hormone binding;GO:0042802|identical protein binding;","K12324","ANPRB, NPR2; atrial natriuretic peptide receptor B [EC:4.6.1.2]"]
["ENSRNOG00000029401",290,24.39922791,970,62.40052504,0.391009978,-1.354722672,{"v":3.00283e-53,"d":"3.00E-53"},{"v":2.23972E-52,"d":"2.24E-52"},"down","yes","Actg2","protein_coding","chr4:116021832-116046465:-","gi|528767717|gb|EPY87376.1|",2078,0,"hypothetical protein CB1_000252031 [Camelus ferus]","gi|672050141|ref|XM_006236728.2|",1343,0,"PREDICTED: Rattus norvegicus actin, gamma 2, smooth muscle, enteric (Actg2), transcript variant X1, mRNA","P63269",786,0,"Actin, gamma-enteric smooth muscle","SPBC32H8.12c",711,0,"COG5277","pfam00022","Actin","Actin.","GO:0008150|biological_process;GO:0010628|positive regulation of gene expression;GO:0014829|vascular smooth muscle contraction;GO:0090131|mesenchyme migration;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005869|dynactin complex;GO:0030027|lamellipodium;GO:0030175|filopodium;GO:0032982|myosin filament;GO:0044297|cell body;GO:0071944|cell periphery;","GO:0003674|molecular_function;GO:0005524|ATP binding;","K12315","ACTG2; actin, gamma-enteric smooth muscle"]
["ENSRNOG00000013436",156,13.12510191,676,43.48737621,0.301814068,-1.728268043,{"v":4.5603e-53,"d":"4.56E-53"},{"v":3.38746e-52,"d":"3.39E-52"},"down","yes","Pde7b","protein_coding","chr1:15182704-15492900:-","gi|672033732|ref|XP_008756813.1|",2685,0,"PREDICTED: cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [Rattus norvegicus]","gi|672033731|ref|XM_008758591.1|",2073,0,"PREDICTED: Rattus norvegicus phosphodiesterase 7B (Pde7b), transcript variant X1, mRNA","Q9QXQ1",850,0,"cAMP-specific 3',5'-cyclic phosphodiesterase 7B",".",".",".",".","pfam00233","PDEase_I","3'5'-cyclic nucleotide phosphodiesterase.","GO:0007165|signal transduction;GO:0019933|cAMP-mediated signaling;",".","GO:0004114|3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0004115|3',5'-cyclic-AMP phosphodiesterase activity;GO:0046872|metal ion binding;","K18436","PDE7; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7 [EC:3.1.4.53]"]
["ENSRNOG00000046662",514,43.24552808,1408,90.57725696,0.477443561,-1.066597895,{"v":5.91308e-53,"d":"5.91E-53"},{"v":4.37443e-52,"d":"4.37E-52"},"down","yes","ENSRNOG00000046662","protein_coding","chrX:134258125-134309617:+","gi|569010022|ref|XP_006528039.1|",4155,0,"PREDICTED: protein DDX26B isoform X1 [Mus musculus]","gi|569010023|ref|XM_006527977.1|",2486,0,"PREDICTED: Mus musculus DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B (Ddx26b), transcript variant X2, mRNA","Q8BND4",1514,0,"Integrator complex subunit 6-like",".",".",".",".","pfam15300","INT_SG_DDX_CT_C","INTS6/SAGE1/DDX26B/CT45 C-terminus. This domain is found at the C-terminus of integrator complex subunit 6 (INTS6), sarcoma antigen 1 (SAGE1), protein DDX26B (DDX26B) and members of the cancer/testis antigen family 45.",".","GO:0016021|integral component of membrane;",".","K13180","DDX26B; ATP-dependent RNA helicase DDX26B [EC:3.6.4.-]"]
["ENSRNOG00000005861",261,21.95930512,904,58.15471612,0.37760145,-1.405063791,{"v":1.74093e-52,"d":"1.74E-52"},{"v":1.28096E-51,"d":"1.28E-51"},"down","yes","Hsd11b1","protein_coding","chr13:104728539-104788687:-","gi|37361816|gb|AAQ91021.1|",5895,0,"LRRGT00065 [Rattus norvegicus]","gi|37361815|gb|AY387051.1|",3315,0,"Rattus norvegicus LRRGT00065 mRNA, complete cds","P11369",1128,0,"LINE-1 retrotransposable element ORF2 protein","BH0611",55.1,8e-07,"COG3344","pfam02994","Transposase_22","L1 transposable element.","GO:0006704|glucocorticoid biosynthetic process;GO:0006706|steroid catabolic process;GO:0006713|glucocorticoid catabolic process;GO:0008212|mineralocorticoid metabolic process;GO:0030324|lung development;GO:0031667|response to nutrient levels;GO:0043456|regulation of pentose-phosphate shunt;GO:0071392|cellular response to estradiol stimulus;","GO:0005737|cytoplasm;GO:0005791|rough endoplasmic reticulum;GO:0030176|integral component of endoplasmic reticulum membrane;GO:0031965|nuclear membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0045177|apical part of cell;","GO:0003845|11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity;GO:0005496|steroid binding;GO:0016491|oxidoreductase activity;GO:0042803|protein homodimerization activity;GO:0050661|NADP binding;GO:0070524|11-beta-hydroxysteroid dehydrogenase (NADP+) activity;","K15680","HSD11B1; corticosteroid 11-beta-dehydrogenase isozyme 1 [EC:1.1.1.146]"]
["ENSRNOG00000009329",107,9.002473745,553,35.57473232,0.253058088,-1.982459509,{"v":2.49509E-52,"d":"2.50E-52"},{"v":1.826e-51,"d":"1.83E-51"},"down","yes","Nr1d1","protein_coding","chr10:83728318-83735705:-","gi|625254396|ref|XP_007618538.1|",2592,0,"PREDICTED: nuclear receptor subfamily 1 group D member 1 isoform X2 [Cricetulus griseus]","gi|583828531|ref|NM_145434.4|",1915,0,"Mus musculus nuclear receptor subfamily 1, group D, member 1 (Nr1d1), mRNA","Q63503",962,0,"Nuclear receptor subfamily 1 group D member 1",".",".",".",".","pfam00105","zf-C4","Zinc finger, C4 type (two domains). In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001678|cellular glucose homeostasis;GO:0005978|glycogen biosynthetic process;GO:0006355|regulation of transcription, DNA-templated;GO:0007623|circadian rhythm;GO:0009648|photoperiodism;GO:0009755|hormone-mediated signaling pathway;GO:0010498|proteasomal protein catabolic process;GO:0019216|regulation of lipid metabolic process;GO:0030154|cell differentiation;GO:0030522|intracellular receptor signaling pathway;GO:0031648|protein destabilization;GO:0032922|circadian regulation of gene expression;GO:0034144|negative regulation of toll-like receptor 4 signaling pathway;GO:0042632|cholesterol homeostasis;GO:0042749|regulation of circadian sleep/wake cycle;GO:0042752|regulation of circadian rhythm;GO:0042753|positive regulation of circadian rhythm;GO:0043124|negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0044321|response to leptin;GO:0045598|regulation of fat cell differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050728|negative regulation of inflammatory response;GO:0060086|circadian temperature homeostasis;GO:0061178|regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0061469|regulation of type B pancreatic cell proliferation;GO:0061889|negative regulation of astrocyte activation;GO:0070859|positive regulation of bile acid biosynthetic process;GO:0071222|cellular response to lipopolysaccharide;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0120163|negative regulation of cold-induced thermogenesis;GO:0150079|negative regulation of neuroinflammatory response;GO:1903979|negative regulation of microglial cell activation;GO:2000489|regulation of hepatic stellate cell activation;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0016604|nuclear body;GO:0030425|dendrite;GO:0043025|neuronal cell body;GO:0043197|dendritic spine;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001222|transcription corepressor binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0004879|nuclear receptor activity;GO:0005515|protein binding;GO:0008270|zinc ion binding;GO:0020037|heme binding;GO:0043565|sequence-specific DNA binding;GO:0070888|E-box binding;GO:1990837|sequence-specific double-stranded DNA binding;","K03728","NR1D1; nuclear receptor subfamily 1 group D member 1"]
["ENSRNOG00000023861",233,19.60351759,840,54.03756808,0.362775719,-1.462850198,{"v":7.72698e-52,"d":"7.73E-52"},{"v":5.58728e-51,"d":"5.59E-51"},"down","yes","Snap91","protein_coding","chr8:87738824-87852367:-","gi|564364792|ref|XP_006243556.1|",2792,0,"PREDICTED: clathrin coat assembly protein AP180 isoform X3 [Rattus norvegicus]","gi|13994176|ref|NM_031728.1|",2737,0,"Rattus norvegicus synaptosomal-associated protein 91 (Snap91), mRNA","Q61548",725,0,"Clathrin coat assembly protein AP180",".",".",".",".","pfam07651","ANTH","ANTH domain. AP180 is an endocytotic accessory proteins that has been implicated in the formation of clathrin-coated pits.  The domain is involved in phosphatidylinositol 4,5-bisphosphate binding and is a universal adaptor for nucleation of clathrin coats.","GO:0006900|vesicle budding from membrane;GO:0007163|establishment or maintenance of cell polarity;GO:0007268|chemical synaptic transmission;GO:0007269|neurotransmitter secretion;GO:0007409|axonogenesis;GO:0015031|protein transport;GO:0016185|synaptic vesicle budding from presynaptic endocytic zone membrane;GO:0030100|regulation of endocytosis;GO:0048268|clathrin coat assembly;GO:0048488|synaptic vesicle endocytosis;GO:0048666|neuron development;GO:0050772|positive regulation of axonogenesis;GO:0051223|regulation of protein transport;GO:0051899|membrane depolarization;GO:0072583|clathrin-dependent endocytosis;GO:1900242|regulation of synaptic vesicle endocytosis;GO:1900244|positive regulation of synaptic vesicle endocytosis;GO:1900275|negative regulation of phospholipase C activity;GO:1904006|negative regulation of phospholipase D activity;GO:1905445|positive regulation of clathrin coat assembly;GO:2000331|regulation of terminal button organization;GO:2000369|regulation of clathrin-dependent endocytosis;GO:2000809|positive regulation of synaptic vesicle clustering;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005905|clathrin-coated pit;GO:0008021|synaptic vesicle;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0030136|clathrin-coated vesicle;GO:0031313|extrinsic component of endosome membrane;GO:0042734|presynaptic membrane;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0043679|axon terminus;GO:0045211|postsynaptic membrane;GO:0048787|presynaptic active zone membrane;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098688|parallel fiber to Purkinje cell synapse;GO:0098830|presynaptic endosome;GO:0098833|presynaptic endocytic zone;GO:0098894|extrinsic component of presynaptic endocytic zone membrane;","GO:0000149|SNARE binding;GO:0000822|inositol hexakisphosphate binding;GO:0005515|protein binding;GO:0005545|1-phosphatidylinositol binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0019901|protein kinase binding;GO:0030276|clathrin binding;GO:0032050|clathrin heavy chain binding;GO:0035615|clathrin adaptor activity;GO:0042169|SH2 domain binding;GO:0043274|phospholipase binding;","K20043","SNAP91, AP180, CALM; clathrin coat assembly protein AP180"]
["ENSRNOG00000006076",209,17.58427115,787,50.62805485,0.347322669,-1.525651519,{"v":1.07532e-51,"d":"1.08E-51"},{"v":7.75493e-51,"d":"7.75E-51"},"down","yes","Steap2","protein_coding","chr4:28348362-28375791:+","gi|537250304|gb|ERE88353.1|",2501,0,"metalloreductase STEAP2 [Cricetulus griseus]","gi|157822622|ref|NM_001107846.1|",3376,0,"Rattus norvegicus STEAP2 metalloreductase (Steap2), mRNA","Q8BWB6",952,0,"Metalloreductase STEAP2","RSp1147",70.1,{"v":3e-12,"d":"3.00E-12"},"COG2085","pfam03807","F420_oxidored","NADP oxidoreductase coenzyme F420-dependent.","GO:0006893|Golgi to plasma membrane transport;GO:0006897|endocytosis;GO:0009725|response to hormone;GO:0015677|copper ion import;GO:0045055|regulated exocytosis;GO:0098705|copper ion import across plasma membrane;GO:0098711|iron ion import across plasma membrane;","GO:0005768|endosome;GO:0005769|early endosome;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0010008|endosome membrane;GO:0030140|trans-Golgi network transport vesicle;GO:0030173|integral component of Golgi membrane;","GO:0008823|cupric reductase activity;GO:0052851|ferric-chelate reductase (NADPH) activity;","K14738","STEAP2; metalloreductase STEAP2 [EC:1.16.1.-]"]
["ENSRNOG00000008249",499,41.98349905,1364,87.74671768,0.478462331,-1.063522749,{"v":4.01393E-51,"d":"4.01E-51"},{"v":2.85689e-50,"d":"2.86E-50"},"down","yes","Brms1l","protein_coding","chr6:73266691-73300631:+","gi|148704772|gb|EDL36719.1|",1020,{"v":6e-172,"d":"6.00E-172"},"mCG22342, isoform CRA_c, partial [Mus musculus]","gi|157822322|ref|NM_001106731.1|",2652,0,"Rattus norvegicus breast cancer metastasis-suppressor 1-like (Brms1l), mRNA","Q5PSV4",345,{"v":2e-161,"d":"2.00E-161"},"Breast cancer metastasis-suppressor 1-like protein",".",".",".",".","pfam08598","Sds3","Sds3-like. Repression of gene transcription is mediated by histone deacetylases containing repressor-co-repressor complexes, which are recruited to promoters of target genes via interactions with sequence-specific transcription factors. The co-repressor complex contains a core of at least seven proteins.  This family represents the conserved region found in Sds3, Dep1 and BRMS1-homologue p40 proteins.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0016575|histone deacetylation;","GO:0070822|Sin3-type complex;","GO:0042826|histone deacetylase binding;","K19196","BRMS1; breast cancer metastasis-suppressor 1 and related proteins"]
["ENSRNOG00000060867",67,5.637062999,440,28.3053928,0.199151555,-2.328061348,{"v":5.51934e-51,"d":"5.52E-51"},{"v":3.90793e-50,"d":"3.91E-50"},"down","yes","Rln1","protein_coding","chr1:227079966-227082882:-","gi|564333247|ref|XP_006231258.1|",899,{"v":1E-119,"d":"1.00E-119"},"PREDICTED: prorelaxin 1 isoform X1 [Rattus norvegicus]","gi|672040050|ref|XM_006231196.2|",781,0,"PREDICTED: Rattus norvegicus relaxin 1 (Rln1), transcript variant X1, mRNA","P01347",345,{"v":4e-119,"d":"4.00E-119"},"Prorelaxin 1",".",".",".",".","pfam00049","Insulin","Insulin/IGF/Relaxin family. Superfamily includes insulins; relaxins; insulin-like growth factor; and bombyxin. All are secreted regulatory hormones. Disulfide rich, all-alpha fold. Alignment includes B chain, linker (which is processed out of the final product), and A chain.","GO:0007188|adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007283|spermatogenesis;GO:0010749|regulation of nitric oxide mediated signal transduction;GO:0042127|regulation of cell proliferation;GO:0042981|regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0048589|developmental growth;GO:0050878|regulation of body fluid levels;GO:0060443|mammary gland morphogenesis;GO:0060618|nipple development;GO:0060736|prostate gland growth;","GO:0005576|extracellular region;","GO:0005102|signaling receptor binding;GO:0005179|hormone activity;","K21998","RLN1_2; relaxin 1/2"]
["ENSRNOG00000016316",405,34.0747838,1182,76.03857793,0.448124948,-1.158027048,{"v":7.66785e-51,"d":"7.67E-51"},{"v":5.41508e-50,"d":"5.42E-50"},"down","yes","Mcm2","protein_coding","chr4:121346434-121360847:-","gi|164607175|ref|NP_001101343.2|",4291,0,"DNA replication licensing factor MCM2 [Rattus norvegicus]","gi|164607174|ref|NM_001107873.2|",3261,0,"Rattus norvegicus minichromosome maintenance complex component 2 (Mcm2), mRNA","P97310",1642,0,"DNA replication licensing factor MCM2","SPBC4.04c",787,0,"COG1241","pfam00493","MCM","MCM2/3/5 family.","GO:0000727|double-strand break repair via break-induced replication;GO:0006268|DNA unwinding involved in DNA replication;GO:0006270|DNA replication initiation;GO:0006334|nucleosome assembly;GO:0006915|apoptotic process;GO:0071353|cellular response to interleukin-4;GO:0090102|cochlea development;GO:1902975|mitotic DNA replication initiation;GO:1905775|negative regulation of DNA helicase activity;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005664|nuclear origin of replication recognition complex;GO:0005737|cytoplasm;GO:0042555|MCM complex;","GO:0003674|molecular_function;GO:0003688|DNA replication origin binding;GO:0003697|single-stranded DNA binding;GO:0005524|ATP binding;GO:0017116|single-stranded DNA-dependent ATP-dependent DNA helicase activity;GO:0019899|enzyme binding;GO:0042393|histone binding;GO:0043138|3'-5' DNA helicase activity;GO:0046872|metal ion binding;","K02540","MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]"]
["ENSRNOG00000003927",121,10.18036751,576,37.05433239,0.274741625,-1.863852589,{"v":2.83754e-50,"d":"2.84E-50"},{"v":1.99354e-49,"d":"1.99E-49"},"down","yes","Cd55","protein_coding","chr13:41857395-41885831:-","gi|625186847|ref|XP_007614661.1|",1977,0,"PREDICTED: complement decay-accelerating factor isoform X2 [Cricetulus griseus]","gi|38511537|gb|BC061869.1|",1396,0,"Rattus norvegicus Cd55 molecule, mRNA (cDNA clone MGC:72267 IMAGE:5598916), complete cds","Q61475",449,{"v":7e-145,"d":"7.00E-145"},"Complement decay-accelerating factor, GPI-anchored",".",".",".",".","pfam05109","Herpes_BLLF1","Herpes virus major outer envelope glycoprotein (BLLF1). This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralizing antibodies in vivo.","GO:0002456|T cell mediated immunity;GO:0002726|positive regulation of T cell cytokine production;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007283|spermatogenesis;GO:0030449|regulation of complement activation;GO:0030450|regulation of complement activation, classical pathway;GO:0031664|regulation of lipopolysaccharide-mediated signaling pathway;GO:0043086|negative regulation of catalytic activity;GO:0043434|response to peptide hormone;GO:0045916|negative regulation of complement activation;GO:0045959|negative regulation of complement activation, classical pathway;GO:0046718|viral entry into host cell;GO:0060137|maternal process involved in parturition;GO:1903659|regulation of complement-dependent cytotoxicity;GO:2000516|positive regulation of CD4-positive, alpha-beta T cell activation;GO:2000563|positive regulation of CD4-positive, alpha-beta T cell proliferation;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016324|apical plasma membrane;GO:0045121|membrane raft;GO:0097225|sperm midpiece;","GO:0001618|virus receptor activity;GO:0004857|enzyme inhibitor activity;GO:0008289|lipid binding;","K04006","DAF, CD55; decay accelerating factor"]
["ENSRNOG00000019718",62,5.216386656,417,26.82579272,0.194454148,-2.362498088,{"v":3.11741e-49,"d":"3.12E-49"},{"v":2.12865e-48,"d":"2.13E-48"},"down","yes","Galnt15","protein_coding","chr16:7227271-7267014:+","gi|392333503|ref|XP_003752912.1|",3313,0,"PREDICTED: polypeptide N-acetylgalactosaminyltransferase 15 isoform X1 [Rattus norvegicus]","gi|672029069|ref|XM_003752864.3|",2746,0,"PREDICTED: Rattus norvegicus polypeptide N-acetylgalactosaminyltransferase 15 (Galnt15), transcript variant X1, mRNA","Q9D2N8",1095,0,"Polypeptide N-acetylgalactosaminyltransferase 15",".",".",".",".","pfam00535","Glycos_transf_2","Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.","GO:0006486|protein glycosylation;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;GO:0030133|transport vesicle;","GO:0004653|polypeptide N-acetylgalactosaminyltransferase activity;GO:0030246|carbohydrate binding;GO:0046872|metal ion binding;","K00710","GALNT; polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41]"]
["ENSRNOG00000016289",144,12.11547869,622,40.01353255,0.302784531,-1.723636594,{"v":8.56228e-49,"d":"8.56E-49"},{"v":5.79134e-48,"d":"5.79E-48"},"down","yes","Bmpr1b","protein_coding","chr2:230541558-230871368:-","gi|564339048|ref|XP_006233462.1|",2649,0,"PREDICTED: bone morphogenetic protein receptor type-1B isoform X1 [Rattus norvegicus]","gi|672044247|ref|XM_008761513.1|",1827,0,"PREDICTED: Rattus norvegicus bone morphogenetic protein receptor, type IB (Bmpr1b), transcript variant X2, mRNA","P36898",1012,0,"Bone morphogenetic protein receptor type-1B","SP1732_1",75.1,{"v":4e-13,"d":"4.00E-13"},"COG0515","pfam00069","Pkinase","Protein kinase domain.","GO:0001501|skeletal system development;GO:0001502|cartilage condensation;GO:0001550|ovarian cumulus expansion;GO:0001649|osteoblast differentiation;GO:0001654|eye development;GO:0002062|chondrocyte differentiation;GO:0006468|protein phosphorylation;GO:0006954|inflammatory response;GO:0007178|transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0008150|biological_process;GO:0008284|positive regulation of cell proliferation;GO:0009953|dorsal/ventral pattern formation;GO:0030154|cell differentiation;GO:0030501|positive regulation of bone mineralization;GO:0030509|BMP signaling pathway;GO:0031290|retinal ganglion cell axon guidance;GO:0035108|limb morphogenesis;GO:0042698|ovulation cycle;GO:0043010|camera-type eye development;GO:0043066|negative regulation of apoptotic process;GO:0045597|positive regulation of cell differentiation;GO:0045669|positive regulation of osteoblast differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0060041|retina development in camera-type eye;GO:0060348|bone development;GO:0071363|cellular response to growth factor stimulus;GO:0071773|cellular response to BMP stimulus;GO:0071902|positive regulation of protein serine/threonine kinase activity;GO:1902043|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0043025|neuronal cell body;GO:0043235|receptor complex;","GO:0003674|molecular_function;GO:0004674|protein serine/threonine kinase activity;GO:0004675|transmembrane receptor protein serine/threonine kinase activity;GO:0005025|transforming growth factor beta receptor activity, type I;GO:0005524|ATP binding;GO:0019211|phosphatase activator activity;GO:0036122|BMP binding;GO:0043539|protein serine/threonine kinase activator activity;GO:0046332|SMAD binding;GO:0046872|metal ion binding;GO:0098821|BMP receptor activity;","K13578","BMPR1B, ALK6, CDw293; bone morphogenetic protein receptor type-1B [EC:2.7.11.30]"]
["ENSRNOG00000000010",97,8.161121059,503,32.35821041,0.252211756,-1.987292573,{"v":6.60968e-48,"d":"6.61E-48"},{"v":4.36756e-47,"d":"4.37E-47"},"down","yes","Cbln1","protein_coding","chr19:19608716-19612572:+","gi|507654072|ref|XP_004704743.1|",942,{"v":2E-118,"d":"2.00E-118"},"PREDICTED: cerebellin-1 [Echinops telfairi]","gi|157820084|ref|NM_001109127.1|",2444,0,"Rattus norvegicus cerebellin 1 precursor (Cbln1), mRNA","Q9R171",367,{"v":9E-120,"d":"9.00E-120"},"Cerebellin-1",".",".",".",".","pfam00386","C1q","C1q domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.","GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0009306|protein secretion;GO:0021707|cerebellar granule cell differentiation;GO:0050808|synapse organization;GO:0051965|positive regulation of synapse assembly;GO:0090394|negative regulation of excitatory postsynaptic potential;GO:0099151|regulation of postsynaptic density assembly;GO:0099558|maintenance of synapse structure;GO:1900454|positive regulation of long-term synaptic depression;GO:1905606|regulation of presynapse assembly;GO:1905703|negative regulation of inhibitory synapse assembly;","GO:0005576|extracellular region;GO:0043083|synaptic cleft;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0098688|parallel fiber to Purkinje cell synapse;GO:0098978|glutamatergic synapse;","GO:0042802|identical protein binding;","K24235","CBLN; cerebellin"]
["ENSRNOG00000003629",237,19.94005867,820,52.75095931,0.378003717,-1.403527676,{"v":1.06726E-47,"d":"1.07E-47"},{"v":7.02668e-47,"d":"7.03E-47"},"down","yes","Nvl","protein_coding","chr13:92853650-92906049:-","gi|157787079|ref|NP_001099450.1|",4241,0,"nuclear valosin-containing protein-like [Rattus norvegicus]","gi|157787078|ref|NM_001105980.1|",2901,0,"Rattus norvegicus nuclear VCP-like (Nvl), mRNA","Q9DBY8",1469,0,"Nuclear valosin-containing protein-like","SPBC16E9.10c",610,0,"COG0464","pfam00004","AAA","ATPase family associated with various cellular activities (AAA). AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.","GO:0006364|rRNA processing;GO:0032092|positive regulation of protein binding;GO:0042254|ribosome biogenesis;GO:0042273|ribosomal large subunit biogenesis;GO:0051973|positive regulation of telomerase activity;GO:1904749|regulation of protein localization to nucleolus;","GO:0000176|nuclear exosome (RNase complex);GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005697|telomerase holoenzyme complex;GO:0005730|nucleolus;","GO:0005524|ATP binding;GO:0016887|ATPase activity;GO:1990275|preribosome binding;","K14571","RIX7, NVL; ribosome biogenesis ATPase"]
["ENSRNOG00000000033",92,7.740444715,488,31.39325383,0.246563951,-2.019966207,{"v":1.70918e-47,"d":"1.71E-47"},{"v":1.11586E-46,"d":"1.12E-46"},"down","yes","Tmcc2","protein_coding","chr13:43794029-43831716:-","gi|760997468|ref|NP_001292057.1|",2836,0,"transmembrane and coiled-coil domains protein 2 [Rattus norvegicus]","gi|760997467|ref|NM_001305128.1|",3516,0,"Rattus norvegicus transmembrane and coiled-coil domain family 2 (Tmcc2), mRNA","Q80W04",1080,0,"Transmembrane and coiled-coil domains protein 2",".",".",".",".","pfam10267","Tmemb_cc2","Predicted transmembrane and coiled-coil 2 protein. This family of transmembrane coiled-coil containing proteins is conserved from worms to humans. Its function is unknown.","GO:0042982|amyloid precursor protein metabolic process;","GO:0005783|endoplasmic reticulum;GO:0012505|endomembrane system;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000061215",173,14.55540148,680,43.74469797,0.332735215,-1.587553534,{"v":1.73152e-47,"d":"1.73E-47"},{"v":1.12909e-46,"d":"1.13E-46"},"down","yes","Crym","protein_coding","chr1:174560416-174575633:-","gi|16758840|ref|NP_446407.1|",1592,0,"ketimine reductase mu-crystallin [Rattus norvegicus]","gi|56789443|gb|BC088121.1|",732,0,"Rattus norvegicus crystallin, mu, mRNA (cDNA clone MGC:108623 IMAGE:7323247), complete cds","Q9QYU4",617,0,"Ketimine reductase mu-crystallin","MA3252",139,{"v":5E-36,"d":"5.00E-36"},"COG2423","pfam02423","OCD_Mu_crystall","Ornithine cyclodeaminase/mu-crystallin family. This family contains the bacterial Ornithine cyclodeaminase enzyme EC:4.3.1.12, which catalyses the deamination of ornithine to proline. This family also contains mu-Crystallin the major component of the eye lens in several Australian marsupials, mRNA for this protein has also been found in human retina.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006839|mitochondrial transport;GO:0007605|sensory perception of sound;GO:0009725|response to hormone;GO:0033280|response to vitamin D;GO:0042403|thyroid hormone metabolic process;GO:0070327|thyroid hormone transport;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;","GO:0003674|molecular_function;GO:0003714|transcription corepressor activity;GO:0042562|hormone binding;GO:0042803|protein homodimerization activity;GO:0047127|thiomorpholine-carboxylate dehydrogenase activity;GO:0050661|NADP binding;GO:0070324|thyroid hormone binding;","K18258","CRYM; thiomorpholine-carboxylate dehydrogenase [EC:1.5.1.25]"]
["ENSRNOG00000032989",332,27.93290919,1012,65.10240344,0.429061105,-1.220744969,{"v":1.86999e-47,"d":"1.87E-47"},{"v":1.21792E-46,"d":"1.22E-46"},"down","yes","Lrrn4","protein_coding","chr3:120139410-120150831:-","gi|109470864|ref|XP_001081242.1|",3504,0,"PREDICTED: leucine-rich repeat neuronal protein 4 [Rattus norvegicus]","gi|672017367|ref|XM_001081242.4|",3172,0,"PREDICTED: Rattus norvegicus leucine rich repeat neuronal 4 (Lrrn4), mRNA","P59383",1113,0,"Leucine-rich repeat neuronal protein 4",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.","GO:0007616|long-term memory;GO:0008542|visual learning;","GO:0005887|integral component of plasma membrane;",".","K24493","LRRN4; leucine-rich repeat neuronal protein 4"]
["ENSRNOG00000006523",494,41.56282271,1321,84.98050884,0.489086536,-1.031838345,{"v":2.934e-47,"d":"2.93E-47"},{"v":1.89729e-46,"d":"1.90E-46"},"down","yes","Atl2","protein_coding","chr6:15139044-15180421:+","gi|213511883|ref|NP_001094141.1|",2843,0,"atlastin-2 [Rattus norvegicus]","gi|213511882|ref|NM_001100671.1|",1930,0,"Rattus norvegicus atlastin GTPase 2 (Atl2), mRNA","Q6PA06",1089,0,"Atlastin-2",".",".",".",".","pfam02263","GBP","Guanylate-binding protein, N-terminal domain. Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.","GO:0007029|endoplasmic reticulum organization;GO:0007030|Golgi organization;GO:0051260|protein homooligomerization;GO:1990809|endoplasmic reticulum tubular network membrane organization;","GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;GO:0098826|endoplasmic reticulum tubular network membrane;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0042802|identical protein binding;","K17339","ATL; atlastin [EC:3.6.5.-]"]
["ENSRNOG00000033192",471,39.62771153,1276,82.08563912,0.482760589,-1.050620189,{"v":4.99523E-47,"d":"5.00E-47"},{"v":3.22637e-46,"d":"3.23E-46"},"down","yes","Osmr","protein_coding","chr2:55907132-55961262:-","gi|564335465|ref|XP_006232074.1|",5038,0,"PREDICTED: oncostatin-M-specific receptor subunit beta isoform X1 [Rattus norvegicus]","gi|672041560|ref|XM_006232012.2|",4611,0,"PREDICTED: Rattus norvegicus oncostatin M receptor (Osmr), transcript variant X1, mRNA","Q65Z14",1944,0,"Oncostatin-M-specific receptor subunit beta",".",".",".",".","pfam00041","fn3","Fibronectin type III domain.","GO:0008284|positive regulation of cell proliferation;GO:0019221|cytokine-mediated signaling pathway;GO:0034097|response to cytokine;GO:0038165|oncostatin-M-mediated signaling pathway;GO:0048861|leukemia inhibitory factor signaling pathway;","GO:0005900|oncostatin-M receptor complex;GO:0009897|external side of plasma membrane;GO:0016020|membrane;GO:0016324|apical plasma membrane;GO:0043235|receptor complex;","GO:0004896|cytokine receptor activity;GO:0004923|leukemia inhibitory factor receptor activity;GO:0004924|oncostatin-M receptor activity;GO:0005127|ciliary neurotrophic factor receptor binding;GO:0019838|growth factor binding;GO:0019955|cytokine binding;","K05057","OSMR; oncostatin M receptor"]
["ENSRNOG00000007748",316,26.58674489,972,62.52918592,0.425189366,-1.233822581,{"v":2.16363e-46,"d":"2.16E-46"},{"v":1.38596e-45,"d":"1.39E-45"},"down","yes","Tex15","protein_coding","chr16:58598989-58658467:-","gi|564389384|ref|XP_006253280.1|",16266,0,"PREDICTED: testis-expressed sequence 15 protein isoform X1 [Rattus norvegicus]","gi|672080305|ref|XM_008771297.1|",9477,0,"PREDICTED: Rattus norvegicus testis expressed 15 (Tex15), transcript variant X3, mRNA","F8VPN2",4348,0,"Testis-expressed protein 15",".",".",".",".","pfam15326","TEX15","Testis expressed sequence 15. TEX15 is a family of eukaryotic proteins that is required for chromosomal synapsis and meiotic recombination. TEX15 regulates the loading of DNA repair proteins onto sites of double-stranded-breaks and, thus, its absence causes a failure in meiotic recombination. Two polymorphisms in the TEX15 gene could be considered the genetic risk factors for spermatogenic failure in the Chinese Han population.","GO:0006306|DNA methylation;GO:0007129|synapsis;GO:0007130|synaptonemal complex assembly;GO:0007140|male meiotic nuclear division;GO:0007283|spermatogenesis;GO:0009566|fertilization;GO:0010529|negative regulation of transposition;GO:0010569|regulation of double-strand break repair via homologous recombination;GO:0030539|male genitalia development;GO:0032880|regulation of protein localization;GO:0034502|protein localization to chromosome;GO:0048873|homeostasis of number of cells within a tissue;","GO:0005634|nucleus;GO:0005737|cytoplasm;",".","K25680","TEX15; testis-expressed protein 15"]
["ENSRNOG00000009729",388,32.64448423,1108,71.27812551,0.457987412,-1.126620149,{"v":8.73371e-46,"d":"8.73E-46"},{"v":5.55534E-45,"d":"5.56E-45"},"down","yes","Ubp1","protein_coding","chr8:113869979-113915625:+","gi|300797079|ref|NP_001178748.1|",2781,0,"upstream-binding protein 1 [Rattus norvegicus]","gi|300797078|ref|NM_001191819.1|",2456,0,"Rattus norvegicus upstream binding protein 1 (LBP-1a) (Ubp1), mRNA","Q811S7",1064,0,"Upstream-binding protein 1",".",".",".",".","pfam04516","CP2","CP2 transcription factor. This family represents a conserved region in the CP2 transcription factor family.","GO:0001525|angiogenesis;GO:0006357|regulation of transcription by RNA polymerase II;GO:0032897|negative regulation of viral transcription;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837|sequence-specific double-stranded DNA binding;","K09275","TFCP2; transcription factor CP2 and related proteins"]
["ENSRNOG00000048818",104,8.750067939,506,32.55120172,0.268809367,-1.895344682,{"v":2.3633e-45,"d":"2.36E-45"},{"v":1.48933E-44,"d":"1.49E-44"},"down","yes","Catsperd","protein_coding","chr9:1460001-1498344:+","gi|564366897|ref|XP_006244402.1|",4059,0,"PREDICTED: cation channel sperm-associated protein subunit delta isoform X3 [Rattus norvegicus]","gi|672063991|ref|XM_006244344.2|",2273,0,"PREDICTED: Rattus norvegicus catsper channel auxiliary subunit delta (Catsperd), transcript variant X6, mRNA","B5DFM7",1420,0,"Cation channel sperm-associated protein subunit delta",".",".",".",".","pfam15020","CATSPERD","Cation channel sperm-associated protein subunit delta. The CATSPER (cation channel of sperm) complex is a tetrameric complex consisting of CATSPER1, CATSPER2, CATSPER3 and CATSPER4, it functions as an alkalinisation-activated calcium channel. This complex requires several auxiliary subunits, including CATSPERD. CATSPERD is essential for the cation channel function and may play a role in channel assembly or transport.","GO:0007283|spermatogenesis;GO:0030317|flagellated sperm motility;GO:0048240|sperm capacitation;","GO:0036128|CatSper complex;GO:0097228|sperm principal piece;",".","K16895","CATSPERD; cation channel sperm-associated protein subunit delta"]
["ENSRNOG00000049028",473,39.79598207,1260,81.05635211,0.490966852,-1.02630247,{"v":8.91828e-45,"d":"8.92E-45"},{"v":5.58145e-44,"d":"5.58E-44"},"down","yes","C5ar2","protein_coding","chr1:76930383-76959517:-","gi|564326422|ref|XP_006228414.1|",1616,0,"PREDICTED: C5a anaphylatoxin chemotactic receptor 2 isoform X2 [Rattus norvegicus]","gi|672035146|ref|XM_006228353.2|",2816,0,"PREDICTED: Rattus norvegicus complement component 5a receptor 2 (C5ar2), transcript variant X2, mRNA","Q695P6",616,0,"C5a anaphylatoxin chemotactic receptor 2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0002430|complement receptor mediated signaling pathway;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0032677|regulation of interleukin-8 production;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0038178|complement component C5a signaling pathway;GO:0050679|positive regulation of epithelial cell proliferation;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0090024|negative regulation of neutrophil chemotaxis;","GO:0005886|plasma membrane;GO:0009925|basal plasma membrane;GO:0016021|integral component of membrane;GO:0045177|apical part of cell;","GO:0004875|complement receptor activity;GO:0004878|complement component C5a receptor activity;GO:0004930|G protein-coupled receptor activity;","K04171","C5AR2, GPR77; C5a anaphylatoxin chemotactic receptor 2"]
["ENSRNOG00000014555",65,5.468792462,399,25.66784484,0.213060056,-2.230667948,{"v":3.77535e-44,"d":"3.78E-44"},{"v":2.32536e-43,"d":"2.33E-43"},"down","yes","Aox4","protein_coding","chr9:59664809-59818169:+","gi|564368520|ref|XP_006245049.1|",6660,0,"PREDICTED: aldehyde oxidase 4 isoform X1 [Rattus norvegicus]","gi|672065176|ref|XM_006244987.2|",4176,0,"PREDICTED: Rattus norvegicus aldehyde oxidase 4 (Aox4), transcript variant X1, mRNA","Q5QE79",2564,0,"Aldehyde oxidase 4","PA1523",516,{"v":1e-160,"d":"1.00E-160"},"COG4631","pfam02738","Ald_Xan_dh_C2","Molybdopterin-binding domain of aldehyde dehydrogenase.","GO:0006805|xenobiotic metabolic process;","GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004031|aldehyde oxidase activity;GO:0005506|iron ion binding;GO:0016491|oxidoreductase activity;GO:0042803|protein homodimerization activity;GO:0043546|molybdopterin cofactor binding;GO:0050250|retinal oxidase activity;GO:0050660|flavin adenine dinucleotide binding;GO:0051287|NAD binding;GO:0051537|2 iron, 2 sulfur cluster binding;GO:0071949|FAD binding;GO:0102797|geranial:oxygen oxidoreductase activity;GO:0102798|heptaldehyde:oxygen oxidoreductase activity;","K00157","AOX; aldehyde oxidase [EC:1.2.3.1]"]
["ENSRNOG00000033087",33,2.776463865,305,19.62078365,0.141506268,-2.821062138,{"v":5.38486e-44,"d":"5.38E-44"},{"v":3.30177e-43,"d":"3.30E-43"},"down","yes","Cdh23","protein_coding","chr20:28240645-28622419:-","gi|17865345|ref|NP_446096.1|",17024,0,"cadherin-23 precursor [Rattus norvegicus]","gi|17865344|ref|NM_053644.1|",10780,0,"Rattus norvegicus cadherin-related 23 (Cdh23), mRNA","P58365",6546,0,"Cadherin-23",".",".",".",".","pfam00028","Cadherin","Cadherin domain.",".",".",".",".","."]
["ENSRNOG00000058003",326,27.42809758,971,62.46485548,0.439096471,-1.187390156,{"v":1.0088E-43,"d":"1.01E-43"},{"v":6.16474e-43,"d":"6.16E-43"},"down","yes","Spon1","protein_coding","chr1:167928972-168228226:+","gi|78070801|gb|AAI07656.1|",3916,0,"Spondin 1, extracellular matrix protein [Rattus norvegicus]","gi|78070800|gb|BC107655.1|",4091,0,"Rattus norvegicus spondin 1, extracellular matrix protein, mRNA (cDNA clone MGC:124557 IMAGE:7935103), complete cds","P35446",1511,0,"Spondin-1",".",".",".",".","pfam06468","Spond_N","Spondin_N. This conserved region is found at the in the N-terminal half of several Spondin proteins. Spondins are involved in patterning axonal growth trajectory through either inhibiting or promoting adhesion of embryonic nerve cells.","GO:0007155|cell adhesion;GO:0010954|positive regulation of protein processing;GO:0032092|positive regulation of protein binding;GO:1902430|negative regulation of amyloid-beta formation;GO:1902993|positive regulation of amyloid precursor protein catabolic process;","GO:0005576|extracellular region;GO:0031012|extracellular matrix;","GO:0046872|metal ion binding;GO:0050693|LBD domain binding;","K24427","SPON1; spondin-1"]
["ENSRNOG00000012862",152,12.78856083,606,38.98424554,0.328044333,-1.608037295,{"v":2.83171E-43,"d":"2.83E-43"},{"v":1.71504e-42,"d":"1.72E-42"},"down","yes","Spsb4","protein_coding","chr8:97536520-97609787:-","gi|21553087|ref|NP_660116.1|",1424,0,"SPRY domain-containing SOCS box protein 4 [Mus musculus]","gi|197927328|ref|NM_001106849.2|",2243,0,"Rattus norvegicus splA/ryanodine receptor domain and SOCS box containing 4 (Spsb4), mRNA","Q8R5B6",553,0,"SPRY domain-containing SOCS box protein 4",".",".",".",".","pfam00622","SPRY","SPRY domain. SPRY Domain is named from SPla and the RYanodine Receptor. Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.","GO:0006511|ubiquitin-dependent protein catabolic process;GO:0016567|protein ubiquitination;GO:0035556|intracellular signal transduction;GO:0042752|regulation of circadian rhythm;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:1902916|positive regulation of protein polyubiquitination;","GO:0005829|cytosol;GO:0019005|SCF ubiquitin ligase complex;","GO:1990756|protein binding, bridging involved in substrate recognition for ubiquitination;","K10343","SPSB1_4, SSB1, SSB4; SPRY domain-containing SOCS box protein 1/4"]
["ENSRNOG00000032946",85,7.151497835,445,28.62704499,0.249816138,-2.001061415,{"v":5.89525E-43,"d":"5.90E-43"},{"v":3.54682e-42,"d":"3.55E-42"},"down","yes","Pdzd7","protein_coding","chr1:243888281-243906839:-","gi|569006117|ref|XP_006526603.1|",2242,0,"PREDICTED: PDZ domain-containing protein 7 isoform X4 [Mus musculus]","gi|755562629|ref|XR_877655.1|",2499,0,"PREDICTED: Mus musculus PDZ domain containing 7 (Pdzd7), transcript variant X10, misc_RNA","Q9H5P4",769,0,"PDZ domain-containing protein 7",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.","GO:0007605|sensory perception of sound;GO:0045184|establishment of protein localization;GO:0050910|detection of mechanical stimulus involved in sensory perception of sound;GO:0060088|auditory receptor cell stereocilium organization;GO:0060117|auditory receptor cell development;","GO:0001917|photoreceptor inner segment;GO:0002141|stereocilia ankle link;GO:0002142|stereocilia ankle link complex;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0005929|cilium;GO:0032391|photoreceptor connecting cilium;GO:0032420|stereocilium;GO:0032426|stereocilium tip;GO:1990696|USH2 complex;","GO:0042802|identical protein binding;","K21882","PDZD7; PDZ domain-containing protein 7"]
["ENSRNOG00000016783",75,6.310145148,415,26.69713185,0.236360414,-2.080939661,{"v":3.58127e-42,"d":"3.58E-42"},{"v":2.11951E-41,"d":"2.12E-41"},"down","yes","Fshr","protein_coding","chr6:5198825-5406785:+","gi|40385885|ref|NP_954707.1|",3396,0,"follicle-stimulating hormone receptor precursor [Rattus norvegicus]","gi|40385884|ref|NM_199237.1|",2303,0,"Rattus norvegicus follicle stimulating hormone receptor (Fshr), mRNA","P20395",1311,0,"Follicle-stimulating hormone receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001541|ovarian follicle development;GO:0001545|primary ovarian follicle growth;GO:0001932|regulation of protein phosphorylation;GO:0003073|regulation of systemic arterial blood pressure;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007188|adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007190|activation of adenylate cyclase activity;GO:0007193|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007283|spermatogenesis;GO:0007286|spermatid development;GO:0007626|locomotory behavior;GO:0008584|male gonad development;GO:0009755|hormone-mediated signaling pathway;GO:0009992|cellular water homeostasis;GO:0010640|regulation of platelet-derived growth factor receptor signaling pathway;GO:0010738|regulation of protein kinase A signaling;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0022602|ovulation cycle process;GO:0031175|neuron projection development;GO:0032350|regulation of hormone metabolic process;GO:0033044|regulation of chromosome organization;GO:0033146|regulation of intracellular estrogen receptor signaling pathway;GO:0033148|positive regulation of intracellular estrogen receptor signaling pathway;GO:0035092|sperm chromatin condensation;GO:0035093|spermatogenesis, exchange of chromosomal proteins;GO:0042699|follicle-stimulating hormone signaling pathway;GO:0043408|regulation of MAPK cascade;GO:0045056|transcytosis;GO:0045670|regulation of osteoclast differentiation;GO:0045779|negative regulation of bone resorption;GO:0060009|Sertoli cell development;GO:0060011|Sertoli cell proliferation;GO:0060065|uterus development;GO:0060408|regulation of acetylcholine metabolic process;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0071711|basement membrane organization;","GO:0005768|endosome;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0043235|receptor complex;","GO:0004930|G protein-coupled receptor activity;GO:0004963|follicle-stimulating hormone receptor activity;GO:0005515|protein binding;GO:0008528|G protein-coupled peptide receptor activity;GO:0017046|peptide hormone binding;","K04247","FSHR; follicle stimulating hormone receptor"]
["ENSRNOG00000046171",75,6.310145148,415,26.69713185,0.236360414,-2.080939661,{"v":3.58127e-42,"d":"3.58E-42"},{"v":2.11951E-41,"d":"2.12E-41"},"down","yes","AABR07035839.1","protein_coding","chr12:21543576-21577112:-","gi|254826556|emb|CBA11522.1|",3589,0,"carbohydrate response element binding protein [Rattus norvegicus]","gi|19424225|ref|NM_133552.1|",3145,0,"Rattus norvegicus MLX interacting protein-like (Mlxipl), mRNA","Q8VIP2",1379,0,"Carbohydrate-responsive element-binding protein",".",".",".",".","pfam00010","HLH","Helix-loop-helix DNA-binding domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006110|regulation of glycolytic process;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008284|positive regulation of cell proliferation;GO:0009749|response to glucose;GO:0010255|glucose mediated signaling pathway;GO:0033137|negative regulation of peptidyl-serine phosphorylation;GO:0042593|glucose homeostasis;GO:0045723|positive regulation of fatty acid biosynthetic process;GO:0045821|positive regulation of glycolytic process;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046889|positive regulation of lipid biosynthetic process;GO:0051726|regulation of cell cycle;GO:0055089|fatty acid homeostasis;GO:0071333|cellular response to glucose stimulus;GO:0090324|negative regulation of oxidative phosphorylation;GO:0097009|energy homeostasis;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0005515|protein binding;GO:0019901|protein kinase binding;GO:0035538|carbohydrate response element binding;GO:0043565|sequence-specific DNA binding;GO:0046982|protein heterodimerization activity;","K09113","MLX; MAX-like protein X"]
["ENSRNOG00000029651",274,23.05306361,854,54.93819421,0.419618153,-1.252851002,{"v":6.3236e-42,"d":"6.32E-42"},{"v":3.69828e-41,"d":"3.70E-41"},"down","yes","Rdh16","protein_coding","chr7:63597536-63624124:+","gi|40363270|ref|NP_954678.1|",1686,0,"retinol dehydrogenase 2 precursor [Rattus norvegicus]","gi|40363269|ref|NM_199208.1|",1821,0,"Rattus norvegicus retinol dehydrogenase 16 (all-trans) (Rdh16), mRNA","P50170",654,0,"Retinol dehydrogenase 2",".",".",".",".","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.","GO:0001523|retinoid metabolic process;GO:0008202|steroid metabolic process;GO:0042572|retinol metabolic process;GO:0042573|retinoic acid metabolic process;GO:0042904|9-cis-retinoic acid biosynthetic process;GO:1900054|positive regulation of retinoic acid biosynthetic process;","GO:0005788|endoplasmic reticulum lumen;GO:0005789|endoplasmic reticulum membrane;GO:0031301|integral component of organelle membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0004745|retinol dehydrogenase activity;GO:0042802|identical protein binding;GO:0047023|androsterone dehydrogenase activity;GO:0047044|androstan-3-alpha,17-beta-diol dehydrogenase activity;","K11154","RDH16; retinol dehydrogenase 16 [EC:1.1.1.-]"]
["ENSRNOG00000047287",360,30.28869671,1022,65.74570782,0.460694663,-1.11811721,{"v":7.1058e-42,"d":"7.11E-42"},{"v":4.15129e-41,"d":"4.15E-41"},"down","yes","Nucks1","protein_coding","chr13:43345115-43370229:+","gi|12248185|ref|NP_073636.1|",418,{"v":7e-44,"d":"7.00E-44"},"nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 [Rattus norvegicus]","gi|672073850|ref|XM_006249797.2|",1659,0,"PREDICTED: Rattus norvegicus nuclear casein kinase and cyclin-dependent kinase substrate 1 (Nucks1), transcript variant X1, mRNA","Q9EPJ0",163,{"v":1e-44,"d":"1.00E-44"},"Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1",".",".",".",".","pfam14812","PBP1_TM","Transmembrane domain of transglycosylase PBP1 at N-terminal. This is the N-terminal, transmembrane, domain of the transglycosylases ()penicillin-binding proteins), the multi-domain membrane proteins essential for cell wall synthesis that are targeted by penicillin antibiotics. The TM domain is a single helix, several of whose residues lie in close proximity to hydrophobic residues in the TGT domain. The TM helix seems to be necessary for stabilizing the protein-membrane interaction, and the resulting orientation limits the interaction between PBPb1 and lipid II in the membrane in a 2D lateral diffusion fashion.","GO:0000724|double-strand break repair via homologous recombination;GO:0001678|cellular glucose homeostasis;GO:0006275|regulation of DNA replication;GO:0006325|chromatin organization;GO:0019046|release from viral latency;GO:0031297|replication fork processing;GO:0036297|interstrand cross-link repair;GO:0042593|glucose homeostasis;GO:0043923|positive regulation by host of viral transcription;GO:0044829|positive regulation by host of viral genome replication;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046626|regulation of insulin receptor signaling pathway;GO:0046628|positive regulation of insulin receptor signaling pathway;GO:0051726|regulation of cell cycle;GO:0060382|regulation of DNA strand elongation;GO:0071481|cellular response to X-ray;GO:1990968|modulation by host of RNA binding by virus;GO:1990969|modulation by host of viral RNA-binding transcription factor activity;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;","GO:0003682|chromatin binding;GO:0003690|double-stranded DNA binding;GO:0003697|single-stranded DNA binding;GO:0003713|transcription coactivator activity;",".","."]
["ENSRNOG00000023187",416,35.00027176,1126,72.4360734,0.483188419,-1.049342219,{"v":1.25956e-41,"d":"1.26E-41"},{"v":7.31919e-41,"d":"7.32E-41"},"down","yes","RGD1565685","protein_coding","chrX:10129657-10150900:+","gi|187937148|ref|NP_001119758.2|",1621,0,"uncharacterized protein CXorf38 homolog [Rattus norvegicus]","gi|187937147|ref|NM_001126286.2|",1341,0,"Rattus norvegicus similar to RIKEN cDNA 1810030O07 (RGD1565685), mRNA",".",".",".",".",".",".",".",".","pfam15112","DUF4559","Domain of unknown function (DUF4559). This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. This family includes human protein CXorf38.",".",".",".",".","."]
["ENSRNOG00000002339",370,31.1300494,1038,66.77499484,0.466193213,-1.101000093,{"v":1.68486E-41,"d":"1.68E-41"},{"v":9.75936e-41,"d":"9.76E-41"},"down","yes","Mark1","protein_coding","chr13:96451487-96555173:-","gi|16758824|ref|NP_446399.1|",3799,0,"serine/threonine-protein kinase MARK1 [Rattus norvegicus]","gi|16758823|ref|NM_053947.1|",2928,0,"Rattus norvegicus microtubule affinity regulating kinase 1 (Mark1), mRNA","O08678",1467,0,"Serine/threonine-protein kinase MARK1",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0000226|microtubule cytoskeleton organization;GO:0001764|neuron migration;GO:0006468|protein phosphorylation;GO:0007010|cytoskeleton organization;GO:0010975|regulation of neuron projection development;GO:0016055|Wnt signaling pathway;GO:0035556|intracellular signal transduction;GO:0050773|regulation of dendrite development;GO:0051654|establishment of mitochondrion localization;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0015630|microtubule cytoskeleton;GO:0030425|dendrite;","GO:0000287|magnesium ion binding;GO:0001786|phosphatidylserine binding;GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0050321|tau-protein kinase activity;GO:0070300|phosphatidic acid binding;","K08798","MARK; MAP/microtubule affinity-regulating kinase [EC:2.7.11.1]"]
["ENSRNOG00000002080",293,24.65163371,888,57.12542911,0.431535204,-1.212449837,{"v":1.99819e-41,"d":"2.00E-41"},{"v":1.15497E-40,"d":"1.15E-40"},"down","yes","Urb1","protein_coding","chr11:30004539-30065363:-","gi|300793894|ref|NP_001178590.1|",11017,0,"nucleolar pre-ribosomal-associated protein 1 [Rattus norvegicus]","gi|300793893|ref|NM_001191661.1|",7292,0,"Rattus norvegicus URB1 ribosome biogenesis 1 homolog (S. cerevisiae) (Urb1), mRNA","Q571H0",3880,0,"Nucleolar pre-ribosomal-associated protein 1",".",".",".",".","pfam11707","Npa1","Ribosome 60S biogenesis N-terminal. Npa1p is required for ribosome biogenesis and operates in the same functional environment as Rsa3p and Dbp6p during early maturation of 60S ribosomal subunits. The protein partners of Npa1p include eight putative helicases as well as the novel Npa2p factor. Npa1p can also associate with a subset of H/ACA and C/D small nucleolar RNPs (snoRNPs) involved in the chemical modification of residues in the vicinity of the peptidyl transferase centre. The protein has also been referred to as Urb1, and this domain at the N-terminal is one of several conserved regions along the length.","GO:0000463|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000466|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);","GO:0001650|fibrillar center;GO:0005730|nucleolus;",".","K14861","URB1; nucleolar pre-ribosomal-associated protein 1"]
["ENSRNOG00000012942",281,23.64201049,862,55.45283772,0.426344466,-1.229908564,{"v":3.84016e-41,"d":"3.84E-41"},{"v":2.19633e-40,"d":"2.20E-40"},"down","yes","Satb1","protein_coding","chr9:4680920-4753251:-","gi|564366630|ref|XP_006244281.1|",3885,0,"PREDICTED: DNA-binding protein SATB1 isoform X2 [Rattus norvegicus]","gi|672063964|ref|XM_006244219.2|",3276,0,"PREDICTED: Rattus norvegicus SATB homeobox 1 (Satb1), transcript variant X6, mRNA","Q60611",1234,0,"DNA-binding protein SATB1",".",".",".",".","pfam02376","CUT","CUT domain. The CUT domain is a DNA-binding motif which can bind independently or in cooperation with the homeodomain, often found downstream of the CUT domain. Multiple copies of the CUT domain can exist in one protein.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006325|chromatin organization;GO:0006338|chromatin remodeling;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008544|epidermis development;GO:0016571|histone methylation;GO:0042110|T cell activation;GO:0043367|CD4-positive, alpha-beta T cell differentiation;GO:0043374|CD8-positive, alpha-beta T cell differentiation;GO:0050798|activated T cell proliferation;GO:0060004|reflex;","GO:0000785|chromatin;GO:0000792|heterochromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0016363|nuclear matrix;GO:0016604|nuclear body;GO:0016605|PML body;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003700|DNA-binding transcription factor activity;GO:0043565|sequence-specific DNA binding;","K23225","SATB1; DNA-binding protein SATB1"]
["ENSRNOG00000029698",367,30.87764359,1028,66.13169045,0.466911452,-1.098779122,{"v":5.47164e-41,"d":"5.47E-41"},{"v":3.1196E-40,"d":"3.12E-40"},"down","yes","Pim3","protein_coding","chr7:119953175-119956587:+","gi|3800869|gb|AAC68900.1|",1984,0,"serine threonine kinase [Rattus norvegicus]","gi|66911970|gb|BC097317.1|",1702,0,"Rattus norvegicus pim-3 oncogene, mRNA (cDNA clone MGC:114318 IMAGE:7446368), complete cds","O70444",552,0,"Serine/threonine-protein kinase pim-3",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006468|protein phosphorylation;GO:0006915|apoptotic process;GO:0007346|regulation of mitotic cell cycle;GO:0016572|histone phosphorylation;GO:0043066|negative regulation of apoptotic process;GO:0046777|protein autophosphorylation;GO:0061179|negative regulation of insulin secretion involved in cellular response to glucose stimulus;","GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;","K08807","PIM3; proto-oncogene serine/threonine-protein kinase Pim-3 [EC:2.7.11.1]"]
["ENSRNOG00000027016",425,35.75748917,1137,73.14370822,0.488866234,-1.032488333,{"v":5.82737E-41,"d":"5.83E-41"},{"v":3.31895E-40,"d":"3.32E-40"},"down","yes","Cobll1","protein_coding","chr3:49753262-49915194:-","gi|564341215|ref|XP_006234366.1|",5598,0,"PREDICTED: cordon-bleu protein-like 1 isoform X14 [Rattus norvegicus]","gi|672045934|ref|XM_006234304.2|",4170,0,"PREDICTED: Rattus norvegicus cordon-bleu WH2 repeat protein-like 1 (Cobll1), transcript variant X14, mRNA","Q3UMF0",1720,0,"Cordon-bleu protein-like 1",".",".",".",".","pfam09469","Cobl","Cordon-bleu ubiquitin-like domain. The Cordon-bleu protein domain is highly conserved among vertebrates. The sequence contains three repeated lysine, arginine, and proline-rich regions, the KKRAP motif. The exact function of the protein is unknown but it is thought to be involved in mid-brain neural tube closure. It is expressed specifically in the node. This domain has a ubiquitin-like fold.",".",".","GO:0003785|actin monomer binding;","K24046","COBLL1; cordon-bleu protein-like 1"]
["ENSRNOG00000004874",348,29.27907349,990,63.6871338,0.459732944,-1.121132044,{"v":8.69326e-41,"d":"8.69E-41"},{"v":4.93057e-40,"d":"4.93E-40"},"down","yes","Flrt3","protein_coding","chr3:127994226-128007841:-","gi|37360402|dbj|BAC98179.1|",3262,0,"mKIAA1469 protein [Mus musculus]","gi|187282103|ref|NM_001126291.1|",2651,0,"Rattus norvegicus fibronectin leucine rich transmembrane protein 3 (Flrt3), mRNA","B1H234",1239,0,"Leucine-rich repeat transmembrane protein FLRT3","SPy1798",74.3,{"v":2E-12,"d":"2.00E-12"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0003345|proepicardium cell migration involved in pericardium morphogenesis;GO:0007411|axon guidance;GO:0007416|synapse assembly;GO:0007507|heart development;GO:0008543|fibroblast growth factor receptor signaling pathway;GO:0031175|neuron projection development;GO:0048598|embryonic morphogenesis;GO:0048678|response to axon injury;GO:0050808|synapse organization;GO:0050919|negative chemotaxis;GO:0051965|positive regulation of synapse assembly;GO:0060322|head development;GO:0098742|cell-cell adhesion via plasma-membrane adhesion molecules;GO:0099560|synaptic membrane adhesion;GO:1990138|neuron projection extension;","GO:0005615|extracellular space;GO:0005789|endoplasmic reticulum membrane;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005911|cell-cell junction;GO:0005925|focal adhesion;GO:0014069|postsynaptic density;GO:0030054|cell junction;GO:0030425|dendrite;GO:0031410|cytoplasmic vesicle;GO:0032584|growth cone membrane;GO:0042734|presynaptic membrane;GO:0043679|axon terminus;GO:0044295|axonal growth cone;GO:0097060|synaptic membrane;GO:0098978|glutamatergic synapse;GO:0099055|integral component of postsynaptic membrane;","GO:0005104|fibroblast growth factor receptor binding;GO:0042803|protein homodimerization activity;GO:0045499|chemorepellent activity;","K16362","FLRT; leucine-rich repeat transmembrane protein FLRT"]
["ENSRNOG00000014004",301,25.32471586,897,57.70440305,0.438869731,-1.188135323,{"v":1.46003E-40,"d":"1.46E-40"},{"v":8.23799e-40,"d":"8.24E-40"},"down","yes","Ncoa7","protein_coding","chr1:26856530-27015871:+","gi|564324906|ref|XP_006227820.1|",4682,0,"PREDICTED: nuclear receptor coactivator 7 isoform X4 [Rattus norvegicus]","gi|672034067|ref|XM_006227758.2|",3866,0,"PREDICTED: Rattus norvegicus nuclear receptor coactivator 7 (Ncoa7), transcript variant X4, mRNA","Q6DFV7",1581,0,"Nuclear receptor coactivator 7","YPL196w",71.6,{"v":1e-12,"d":"1.00E-12"},"COG5142","pfam07534","TLD","TLD. This domain is predicted to be an enzyme and is often found associated with pfam01476. It's structure consists of a beta-sandwich surrounded by two helices and two one-turn helices.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0006979|response to oxidative stress;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:1900408|negative regulation of cellular response to oxidative stress;GO:1902083|negative regulation of peptidyl-cysteine S-nitrosylation;GO:1903204|negative regulation of oxidative stress-induced neuron death;","GO:0005634|nucleus;","GO:0016922|nuclear receptor binding;GO:0030374|nuclear receptor transcription coactivator activity;","K25442","NCOA7; nuclear receptor coactivator 7"]
["ENSRNOG00000068024",55,4.627439776,352,22.64431424,0.204353275,-2.29086273,{"v":2.18934e-40,"d":"2.19E-40"},{"v":1.23274e-39,"d":"1.23E-39"},"down","yes","B3gnt8","protein_coding","chr1:81135499-81142263:+","gi|157819259|ref|NP_001100962.1|",1890,0,"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 [Rattus norvegicus]","gi|672035067|ref|XM_006228434.2|",2663,0,"PREDICTED: Rattus norvegicus UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 (B3gnt8), transcript variant X3, mRNA","Q8R3I9",717,0,"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8","VNG1926G",67.4,{"v":1E-10,"d":"1.00E-10"},"COG1071","pfam01762","Galactosyl_T","Galactosyltransferase. This family includes the galactosyltransferases UDP-galactose:2-acetamido-2-deoxy-D-glucose3beta-galactosyltransferase and UDP-Gal:beta-GlcNAc beta 1,3-galactosyltranferase. Specific galactosyltransferases transfer galactose to GlcNAc terminal chains in the synthesis of the lacto-series oligosaccharides types 1 and 2.",".",".",".",".","."]
["ENSRNOG00000010997",438,36.85124767,1156,74.36598654,0.495539014,-1.012929448,{"v":2.21559e-40,"d":"2.22E-40"},{"v":1.24623e-39,"d":"1.25E-39"},"down","yes","Ednrb","protein_coding","chr15:80643043-80672115:-","gi|148668175|gb|EDL00505.1|",2110,0,"endothelin receptor type B, isoform CRA_b, partial [Mus musculus]","gi|8393332|ref|NM_017333.1|",1994,0,"Rattus norvegicus endothelin receptor type B (Ednrb), mRNA","P21451",812,0,"Endothelin receptor type B",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001755|neural crest cell migration;GO:0001934|positive regulation of protein phosphorylation;GO:0002001|renin secretion into blood stream;GO:0002027|regulation of heart rate;GO:0006885|regulation of pH;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0007422|peripheral nervous system development;GO:0007497|posterior midgut development;GO:0007568|aging;GO:0008217|regulation of blood pressure;GO:0008284|positive regulation of cell proliferation;GO:0010033|response to organic substance;GO:0010467|gene expression;GO:0014043|negative regulation of neuron maturation;GO:0014070|response to organic cyclic compound;GO:0014826|vein smooth muscle contraction;GO:0019233|sensory perception of pain;GO:0019722|calcium-mediated signaling;GO:0019934|cGMP-mediated signaling;GO:0030202|heparin metabolic process;GO:0030318|melanocyte differentiation;GO:0031620|regulation of fever generation;GO:0032269|negative regulation of cellular protein metabolic process;GO:0032341|aldosterone metabolic process;GO:0032496|response to lipopolysaccharide;GO:0035645|enteric smooth muscle cell differentiation;GO:0035810|positive regulation of urine volume;GO:0035812|renal sodium excretion;GO:0035815|positive regulation of renal sodium excretion;GO:0042045|epithelial fluid transport;GO:0042310|vasoconstriction;GO:0042311|vasodilation;GO:0043066|negative regulation of apoptotic process;GO:0043473|pigmentation;GO:0048066|developmental pigmentation;GO:0048246|macrophage chemotaxis;GO:0048265|response to pain;GO:0048484|enteric nervous system development;GO:0050678|regulation of epithelial cell proliferation;GO:0051930|regulation of sensory perception of pain;GO:0055078|sodium ion homeostasis;GO:0060070|canonical Wnt signaling pathway;GO:0060406|positive regulation of penile erection;GO:0060465|pharynx development;GO:0061028|establishment of endothelial barrier;GO:0070294|renal sodium ion absorption;GO:0070588|calcium ion transmembrane transport;GO:0071222|cellular response to lipopolysaccharide;GO:0071806|protein transmembrane transport;GO:0072112|glomerular visceral epithelial cell differentiation;GO:0086100|endothelin receptor signaling pathway;GO:0097018|renal albumin absorption;GO:1904383|response to sodium phosphate;GO:1990839|response to endothelin;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0031965|nuclear membrane;GO:0045121|membrane raft;","GO:0004930|G protein-coupled receptor activity;GO:0004962|endothelin receptor activity;GO:0017046|peptide hormone binding;GO:0031702|type 1 angiotensin receptor binding;GO:0038023|signaling receptor activity;","K04198","EDNRB; endothelin receptor type B"]
["ENSRNOG00000048118",253,21.28622297,800,51.46435055,0.413611029,-1.27365344,{"v":2.29642e-40,"d":"2.30E-40"},{"v":1.29037E-39,"d":"1.29E-39"},"down","yes","Ankra2","protein_coding","chr2:29612925-29623730:+","gi|46485431|ref|NP_997478.1|",1683,0,"ankyrin repeat family A protein 2 [Rattus norvegicus]","gi|564299675|ref|XM_003753510.2|",1807,0,"PREDICTED: Rattus norvegicus ankyrin repeat family A protein 2-like (LOC100910438), transcript variant X1, mRNA","Q2KI79",639,0,"Ankyrin repeat family A protein 2","all2748",89.4,{"v":3e-18,"d":"3.00E-18"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0010468|regulation of gene expression;GO:0043254|regulation of protein complex assembly;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016020|membrane;GO:0032991|protein-containing complex;","GO:0019901|protein kinase binding;GO:0031625|ubiquitin protein ligase binding;GO:0042826|histone deacetylase binding;GO:0050750|low-density lipoprotein particle receptor binding;","K21486","ANKRA2; ankyrin repeat family A protein 2"]
["ENSRNOG00000015156",10,0.841352686,207,13.3164007,0.063181689,-3.984349688,{"v":5.7687e-40,"d":"5.77E-40"},{"v":3.20834e-39,"d":"3.21E-39"},"down","yes","Gal","protein_coding","chr1:200650439-200654959:-","gi|15147221|ref|NP_150240.1|",513,{"v":2e-63,"d":"2.00E-63"},"galanin peptides preproprotein [Rattus norvegicus]","gi|15147220|ref|NM_033237.1|",555,0,"Rattus norvegicus galanin/GMAP prepropeptide (Gal), mRNA","P10683",202,{"v":7e-65,"d":"7.00E-65"},"Galanin peptides",".",".",".",".","pfam06540","GMAP","Galanin message associated peptide (GMAP). This family consists of several galanin message associated peptides. In rat preprogalanin, galanin is C-terminally flanked by a 60 amino acid long peptide: galanin message-associated peptide (GMAP). GMAP sequences in different species show high degree of homology, but the biological function of this family is unknown.","GO:0006954|inflammatory response;GO:0007218|neuropeptide signaling pathway;GO:0007399|nervous system development;GO:0007631|feeding behavior;GO:0008285|negative regulation of cell proliferation;GO:0009410|response to xenobiotic stimulus;GO:0010737|protein kinase A signaling;GO:0019933|cAMP-mediated signaling;GO:0031943|regulation of glucocorticoid metabolic process;GO:0032868|response to insulin;GO:0035902|response to immobilization stress;GO:0043065|positive regulation of apoptotic process;GO:0043627|response to estrogen;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050672|negative regulation of lymphocyte proliferation;GO:0050776|regulation of immune response;GO:0051464|positive regulation of cortisol secretion;GO:0051795|positive regulation of timing of catagen;GO:0090274|positive regulation of somatostatin secretion;GO:0090275|negative regulation of somatostatin secretion;GO:1902608|positive regulation of large conductance calcium-activated potassium channel activity;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0030141|secretory granule;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0044306|neuron projection terminus;","GO:0001664|G protein-coupled receptor binding;GO:0004966|galanin receptor activity;GO:0005184|neuropeptide hormone activity;GO:0031763|galanin receptor binding;GO:0031764|type 1 galanin receptor binding;GO:0031765|type 2 galanin receptor binding;GO:0031766|type 3 galanin receptor binding;","K05244","GAL; galanin"]
["ENSRNOG00000007405",302,25.40885113,894,57.51141174,0.44180538,-1.178517107,{"v":6.18125e-40,"d":"6.18E-40"},{"v":3.43078e-39,"d":"3.43E-39"},"down","yes","Krba1","protein_coding","chr4:77340959-77363613:+","gi|62647202|ref|XP_342682.2|",5066,0,"PREDICTED: protein KRBA1 isoform X3 [Rattus norvegicus]","gi|672018267|ref|XM_006224909.2|",4604,0,"PREDICTED: Rattus norvegicus KRAB-A domain containing 1 (Krba1), transcript variant X4, mRNA","Q6NXZ1",1641,0,"Protein KRBA1",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000055300",402,33.822378,1085,69.79852543,0.484571526,-1.045218461,{"v":6.30449e-40,"d":"6.30E-40"},{"v":3.49206e-39,"d":"3.49E-39"},"down","yes","Ncapd2","protein_coding","chr4:157968815-157992020:-","gi|392340126|ref|XP_001065923.3|",6670,0,"PREDICTED: condensin complex subunit 1 isoform X2 [Rattus norvegicus]","gi|564304336|ref|XM_001065923.4|",4466,0,"PREDICTED: Rattus norvegicus non-SMC condensin I complex, subunit D2 (Ncapd2), transcript variant X2, mRNA","Q8K2Z4",2393,0,"Condensin complex subunit 1","SPBC776.13",273,{"v":3e-74,"d":"3.00E-74"},"COG5098","pfam12717","Cnd1","non-SMC mitotic condensation complex subunit 1. The three non-SMC (structural maintenance of chromosomes) subunits of the mitotic condensation complex are Cnd1-3. The whole complex is essential for viability and the condensing of chromosomes in mitosis.","GO:0007076|mitotic chromosome condensation;GO:0010032|meiotic chromosome condensation;GO:0051301|cell division;","GO:0000228|nuclear chromosome;GO:0000779|condensed chromosome, centromeric region;GO:0000793|condensed chromosome;GO:0000796|condensin complex;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0045120|pronucleus;","GO:0003682|chromatin binding;GO:0042393|histone binding;","K06677","YCS4, CNAP1, CAPD2; condensin complex subunit 1"]
["ENSRNOG00000019955",200,16.82705373,685,44.06635016,0.381857215,-1.388894813,{"v":1.5773E-39,"d":"1.58E-39"},{"v":8.64001e-39,"d":"8.64E-39"},"down","yes","Ogdhl","protein_coding","chr16:7578367-7604386:+","gi|157819765|ref|NP_001099532.1|",5502,0,"2-oxoglutarate dehydrogenase-like, mitochondrial [Rattus norvegicus]","gi|157819764|ref|NM_001106062.1|",3526,0,"Rattus norvegicus oxoglutarate dehydrogenase-like (Ogdhl), mRNA","Q9ULD0",1916,0,"2-oxoglutarate dehydrogenase-like, mitochondrial","SPBC3H7.03c",835,0,"COG0567","pfam00676","E1_dh","Dehydrogenase E1 component. This family uses thiamine pyrophosphate as a cofactor. This family includes pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and 2-oxoisovalerate dehydrogenase.","GO:0006096|glycolytic process;GO:0006099|tricarboxylic acid cycle;GO:0006103|2-oxoglutarate metabolic process;","GO:0005739|mitochondrion;GO:0005759|mitochondrial matrix;GO:0045252|oxoglutarate dehydrogenase complex;","GO:0004591|oxoglutarate dehydrogenase (succinyl-transferring) activity;GO:0030976|thiamine pyrophosphate binding;GO:0046872|metal ion binding;","K00164","OGDH, sucA; 2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]"]
["ENSRNOG00000052840",187,15.73329524,657,42.26509789,0.372252663,-1.425645926,{"v":1.91639e-39,"d":"1.92E-39"},{"v":1.04763E-38,"d":"1.05E-38"},"down","yes","Tanc2","protein_coding","chr10:90553002-90868756:+","gi|672069731|ref|XP_008766576.1|",9858,0,"PREDICTED: protein TANC2 isoform X3 [Rattus norvegicus]","gi|672069728|ref|XM_008768353.1|",6537,0,"PREDICTED: Rattus norvegicus tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 (Tanc2), transcript variant X3, mRNA","A2A690",3680,0,"Protein TANC2","all2748",150,{"v":7e-37,"d":"7.00E-37"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0001701|in utero embryonic development;GO:0060998|regulation of dendritic spine development;GO:0061001|regulation of dendritic spine morphogenesis;GO:0099519|dense core granule cytoskeletal transport;","GO:0030424|axon;GO:0043197|dendritic spine;GO:0098978|glutamatergic synapse;GO:0099092|postsynaptic density, intracellular component;","GO:0005515|protein binding;",".","."]
["ENSRNOG00000021735",138,11.61066707,546,35.12441925,0.330558265,-1.597023509,{"v":8.59501e-39,"d":"8.60E-39"},{"v":4.63811e-38,"d":"4.64E-38"},"down","yes","Akr1c15","protein_coding","chr17:66181493-66208061:-","gi|158138555|ref|NP_001103370.1|",1663,0,"aldo-keto reductase family 1, member C-like [Rattus norvegicus]","gi|158138554|ref|NM_001109900.1|",1302,0,"Rattus norvegicus aldo-keto reductase family 1, member C-like (Akr1cl), mRNA","P52898",485,{"v":3e-169,"d":"3.00E-169"},"Dihydrodiol dehydrogenase 3","slr0942",209,{"v":3e-62,"d":"3.00E-62"},"COG0656","pfam00248","Aldo_ket_red","Aldo/keto reductase family. This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.","GO:0008202|steroid metabolic process;","GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004032|alditol:NADP+ 1-oxidoreductase activity;GO:0004033|aldo-keto reductase (NADP) activity;GO:0016229|steroid dehydrogenase activity;GO:0047086|ketosteroid monooxygenase activity;GO:0047834|D-threo-aldose 1-dehydrogenase activity;GO:0047886|farnesol dehydrogenase activity;","K04119","AKR1C3; aldo-keto reductase family 1 member C3 [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]"]
["ENSRNOG00000065098",341,28.69012661,959,61.69289022,0.465047536,-1.104549901,{"v":1.15172e-38,"d":"1.15E-38"},{"v":6.19048e-38,"d":"6.19E-38"},"down","yes","ENSRNOG00000065098","protein_coding","chr1:222796915-222798193:-","gi|148673911|gb|EDL05858.1|",939,{"v":2e-122,"d":"2.00E-122"},"mCG144566, partial [Mus musculus]","gi|195539711|gb|BC168143.1|",1247,0,"Rattus norvegicus high mobility group box 1, mRNA (cDNA clone MGC:187291 IMAGE:9100911), complete cds","P63159",311,{"v":6E-103,"d":"6.00E-103"},"High mobility group protein B1","YBR089c-a",62.8,{"v":3E-11,"d":"3.00E-11"},"COG5648","pfam09011","HMG_box_2","HMG-box domain. This short 71 residue domain is an HMG-box domain. HMG-box domains mediate re-modelling of chromatin-structure. Mammalian HMG-box proteins are of two types: those that are non-sequence-specific DNA-binding proteins with two HMG-box domains and a long highly acidic C-tail; and a diverse group of sequence-specific transcription factor-proteins with either a single HMG-box or up to six copies, and no acidic C-tail.",".",".",".",".","."]
["ENSRNOG00000016196",127,10.68517912,519,33.38749742,0.320035341,-1.643696867,{"v":1.89065E-38,"d":"1.89E-38"},{"v":1.01322e-37,"d":"1.01E-37"},"down","yes","Dlgap1","protein_coding","chr9:110167448-110726817:+","gi|748585196|ref|NP_075235.3|",4701,0,"disks large-associated protein 1 isoform 1 [Rattus norvegicus]","gi|748585195|ref|NM_022946.3|",6417,0,"Rattus norvegicus discs large homolog associated protein 1 (Dlgap1), transcript variant 1, mRNA","P97836",1808,0,"Disks large-associated protein 1",".",".",".",".","pfam03359","GKAP","Guanylate-kinase-associated protein (GKAP) protein.","GO:0007268|chemical synaptic transmission;GO:0035418|protein localization to synapse;GO:0061136|regulation of proteasomal protein catabolic process;GO:0070842|aggresome assembly;GO:0098962|regulation of postsynaptic neurotransmitter receptor activity;GO:0099562|maintenance of postsynaptic density structure;","GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0098978|glutamatergic synapse;GO:0099092|postsynaptic density, intracellular component;GO:0099572|postsynaptic specialization;","GO:0005515|protein binding;GO:0019904|protein domain specific binding;GO:0044877|protein-containing complex binding;GO:0060090|molecular adaptor activity;GO:0098919|structural constituent of postsynaptic density;","K15008","DLGAP1, GKAP; discs, large-associated protein 1"]
["ENSRNOG00000007447",417,35.08440703,1098,70.63482113,0.496701294,-1.009549591,{"v":3.06662e-38,"d":"3.07E-38"},{"v":1.63219e-37,"d":"1.63E-37"},"down","yes","Pla2g4b","protein_coding","chr3:107005489-107013853:+","gi|167900429|ref|NP_001101234.2|",3993,0,"cytosolic phospholipase A2 beta [Rattus norvegicus]","gi|167900428|ref|NM_001107764.2|",2812,0,"Rattus norvegicus phospholipase A2 group IVB (Pla2g4b), mRNA","P0C871",1425,0,"Cytosolic phospholipase A2 beta",".",".",".",".","pfam01735","PLA2_B","Lysophospholipase catalytic domain. This family consists of Lysophospholipase / phospholipase B EC:3.1.1.5 and cytosolic phospholipase A2 EC:3.1.4 which also has a C2 domain pfam00168. Phospholipase B enzymes catalyse the release of fatty acids from lysophsopholipids and are capable in vitro of hydrolysing all phospholipids extractable form yeast cells. Cytosolic phospholipase A2 associates with natural membranes in response to physiological increases in Ca2+ and selectively hydrolyses arachidonyl phospholipids, the aligned region corresponds the the carboxy-terminal Ca2+-independent catalytic domain of the protein as discussed in.","GO:0036151|phosphatidylcholine acyl-chain remodeling;GO:0036152|phosphatidylethanolamine acyl-chain remodeling;GO:0046475|glycerophospholipid catabolic process;","GO:0005743|mitochondrial inner membrane;GO:0005829|cytosol;GO:0031901|early endosome membrane;","GO:0004622|lysophospholipase activity;GO:0004623|phospholipase A2 activity;GO:0005509|calcium ion binding;GO:0005544|calcium-dependent phospholipid binding;GO:0008970|phospholipase A1 activity;GO:0047498|calcium-dependent phospholipase A2 activity;","K16342","PLA2G4, CPLA2; cytosolic phospholipase A2 [EC:3.1.1.4]"]
["ENSRNOG00000008694",209,17.58427115,694,44.6453241,0.393865909,-1.344223546,{"v":3.67663e-38,"d":"3.68E-38"},{"v":1.95495e-37,"d":"1.95E-37"},"down","yes","Miox","protein_coding","chr7:120405031-120407537:+","gi|56090638|ref|NP_665714.2|",1415,0,"inositol oxygenase [Rattus norvegicus]","gi|298906354|emb|FQ219187.1|",1010,0,"Rattus norvegicus TL0ABA47YA19 mRNA sequence","Q9QXN4",549,0,"Inositol oxygenase",".",".",".",".","pfam05153","DUF706","Family of unknown function (DUF706). Family of uncharacterized eukaryotic function. Some members have a described putative function, but a common theme is not evident.","GO:0019310|inositol catabolic process;","GO:0005737|cytoplasm;GO:0016234|inclusion body;","GO:0004033|aldo-keto reductase (NADP) activity;GO:0008199|ferric iron binding;GO:0016651|oxidoreductase activity, acting on NAD(P)H;GO:0016701|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen;GO:0050113|inositol oxygenase activity;GO:0050661|NADP binding;","K00469","MIOX; inositol oxygenase [EC:1.13.99.1]"]
["ENSRNOG00000032699",82,6.899092029,410,26.37547966,0.261572192,-1.93471892,{"v":4.60552e-38,"d":"4.61E-38"},{"v":2.44409e-37,"d":"2.44E-37"},"down","yes","Ttyh1","protein_coding","chr1:70053324-70071845:-","gi|157819361|ref|NP_001099695.1|",1592,0,"protein tweety homolog 1 [Rattus norvegicus]","gi|672034966|ref|XM_006228216.2|",3076,0,"PREDICTED: Rattus norvegicus tweety family member 1 (Ttyh1), transcript variant X1, mRNA","P0C5X8",617,0,"Protein tweety homolog 1",".",".",".",".","pfam04906","Tweety","Tweety. The tweety (tty) gene has not been characterized at the protein level. However, it is thought to form a membrane protein with five potential membrane-spanning regions. A number of potential functions have been suggested in.","GO:0000278|mitotic cell cycle;GO:0006821|chloride transport;GO:0031589|cell-substrate adhesion;GO:0046847|filopodium assembly;GO:0098609|cell-cell adhesion;","GO:0005886|plasma membrane;GO:0030868|smooth endoplasmic reticulum membrane;GO:0031527|filopodium membrane;GO:0032433|filopodium tip;GO:0034707|chloride channel complex;GO:0045202|synapse;","GO:0005229|intracellular calcium activated chloride channel activity;GO:0005509|calcium ion binding;GO:0072320|volume-sensitive chloride channel activity;","K22641","TTYH; protein tweety"]
["ENSRNOG00000014426",151,12.70442557,569,36.60401933,0.347077337,-1.526670928,{"v":6.75904e-38,"d":"6.76E-38"},{"v":3.56954E-37,"d":"3.57E-37"},"down","yes","Lox","protein_coding","chr18:45967343-46041477:-","gi|8393733|ref|NP_058757.1|",1816,0,"protein-lysine 6-oxidase precursor [Rattus norvegicus]","gi|148747289|ref|NM_017061.2|",1783,0,"Rattus norvegicus lysyl oxidase (Lox), mRNA","P16636",704,0,"Protein-lysine 6-oxidase",".",".",".",".","pfam01186","Lysyl_oxidase","Lysyl oxidase.","GO:0001568|blood vessel development;GO:0001649|osteoblast differentiation;GO:0001932|regulation of protein phosphorylation;GO:0007507|heart development;GO:0009410|response to xenobiotic stimulus;GO:0009725|response to hormone;GO:0010468|regulation of gene expression;GO:0016202|regulation of striated muscle tissue development;GO:0017015|regulation of transforming growth factor beta receptor signaling pathway;GO:0018057|peptidyl-lysine oxidation;GO:0018158|protein oxidation;GO:0030199|collagen fibril organization;GO:0030282|bone mineralization;GO:0030324|lung development;GO:0035791|platelet-derived growth factor receptor-beta signaling pathway;GO:0035904|aorta development;GO:0035905|ascending aorta development;GO:0035906|descending aorta development;GO:0042060|wound healing;GO:0042981|regulation of apoptotic process;GO:0043491|protein kinase B signaling;GO:0045652|regulation of megakaryocyte differentiation;GO:0046716|muscle cell cellular homeostasis;GO:0048251|elastic fiber assembly;GO:0048514|blood vessel morphogenesis;GO:0048545|response to steroid hormone;GO:0055001|muscle cell development;GO:0060326|cell chemotaxis;GO:0061448|connective tissue development;GO:0071310|cellular response to organic substance;GO:0071897|DNA biosynthetic process;GO:1900120|regulation of receptor binding;GO:1903010|regulation of bone development;GO:1990869|cellular response to chemokine;GO:2000586|regulation of platelet-derived growth factor receptor-beta signaling pathway;","GO:0005576|extracellular region;GO:0005581|collagen trimer;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0031012|extracellular matrix;","GO:0004720|protein-lysine 6-oxidase activity;GO:0005507|copper ion binding;GO:0005518|collagen binding;","K00277","LOX; protein-lysine 6-oxidase [EC:1.4.3.13]"]
["ENSRNOG00000012543",271,22.8006578,816,52.49363756,0.434350883,-1.203067126,{"v":9.21731e-38,"d":"9.22E-38"},{"v":4.85366e-37,"d":"4.85E-37"},"down","yes","Mcm3","protein_coding","chr9:23219169-23237314:-","gi|558611343|ref|NP_001178734.2|",3956,0,"DNA replication licensing factor MCM3 [Rattus norvegicus]","gi|558611342|ref|NM_001191805.2|",2932,0,"Rattus norvegicus minichromosome maintenance complex component 3 (Mcm3), mRNA","P25206",1493,0,"DNA replication licensing factor MCM3","SPCC1682.02c",658,0,"COG1241","pfam00493","MCM","MCM2/3/5 family.","GO:0000727|double-strand break repair via break-induced replication;GO:0006271|DNA strand elongation involved in DNA replication;GO:0032508|DNA duplex unwinding;GO:1902975|mitotic DNA replication initiation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005694|chromosome;GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0042555|MCM complex;GO:0048471|perinuclear region of cytoplasm;","GO:0003697|single-stranded DNA binding;GO:0005524|ATP binding;GO:0017116|single-stranded DNA-dependent ATP-dependent DNA helicase activity;","K02541","MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]"]
["ENSRNOG00000015212",370,31.1300494,1005,64.65209038,0.48150105,-1.054389151,{"v":1.27937e-37,"d":"1.28E-37"},{"v":6.70451e-37,"d":"6.70E-37"},"down","yes","Hspa14","protein_coding","chr17:74728899-74749727:+","gi|51948484|ref|NP_001004257.1|",2684,0,"heat shock 70 kDa protein 14 [Rattus norvegicus]","gi|51948483|ref|NM_001004257.1|",1737,0,"Rattus norvegicus heat shock protein family A, member 14 (Hspa14), mRNA","Q6AYB4",1038,0,"Heat shock 70 kDa protein 14","YBL075c",330,{"v":7e-103,"d":"7.00E-103"},"COG0443","pfam00012","HSP70","Hsp70 protein. Hsp70 chaperones help to fold many proteins. Hsp70 assisted folding involves repeated cycles of substrate binding and release. Hsp70 activity is ATP dependent. Hsp70 proteins are made up of two regions: the amino terminus is the ATPase domain and the carboxyl terminus is the substrate binding region.","GO:0016192|vesicle-mediated transport;GO:0034620|cellular response to unfolded protein;GO:0042026|protein refolding;GO:0051085|chaperone cofactor-dependent protein refolding;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005840|ribosome;GO:0005886|plasma membrane;","GO:0005524|ATP binding;GO:0016887|ATPase activity;GO:0031072|heat shock protein binding;GO:0044183|protein binding involved in protein folding;GO:0051082|unfolded protein binding;GO:0051787|misfolded protein binding;",".","."]
["ENSRNOG00000067598",61,5.132251387,352,22.64431424,0.22664636,-2.141485106,{"v":2.64574e-37,"d":"2.65E-37"},{"v":1.37853E-36,"d":"1.38E-36"},"down","yes","ENSRNOG00000067598","lncRNA","chr2:173499695-173508313:+",".",".",".",".","gi|354789111|gb|JN953612.1|",613,0,"Mus musculus targeted deletion, lacZ-tagged mutant allele Gpatch4:tm3(EUCOMM)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam14880","COX14","Cytochrome oxidase c assembly. COX14 plays an essential role in cytochrome oxidase assembly. The COX14 product is a low-molecular weight membrane protein of mitochondria, but it is not a subunit of cytochrome oxidase. Orthology-prediction methods have identified the vertebrate C12orf62 orthologues to be orthologues of the yeast COX14.",".",".",".",".","."]
["ENSRNOG00000006096",5,0.420676343,176,11.32215712,0.037155141,-4.750294349,{"v":3.63554e-37,"d":"3.64E-37"},{"v":1.88883e-36,"d":"1.89E-36"},"down","yes","Slc26a7","protein_coding","chr5:27887042-28021658:-","gi|568926289|ref|XP_006537785.1|",3239,0,"PREDICTED: anion exchange transporter isoform X1 [Mus musculus]","gi|755506183|ref|XM_006537723.2|",2033,0,"PREDICTED: Mus musculus solute carrier family 26, member 7 (Slc26a7), transcript variant X2, mRNA","Q8R2Z3",1165,0,"Anion exchange transporter","lin0529",113,{"v":3e-25,"d":"3.00E-25"},"COG0659","pfam00916","Sulfate_transp","Sulfate transporter family. Mutations in human SLC26A2 lead to several human diseases.","GO:0001696|gastric acid secretion;GO:0006820|anion transport;GO:0006821|chloride transport;GO:0008272|sulfate transport;GO:0015701|bicarbonate transport;GO:0019532|oxalate transport;GO:1902358|sulfate transmembrane transport;GO:1902476|chloride transmembrane transport;","GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005887|integral component of plasma membrane;GO:0016323|basolateral plasma membrane;","GO:0005253|anion channel activity;GO:0005254|chloride channel activity;GO:0008271|secondary active sulfate transmembrane transporter activity;GO:0015106|bicarbonate transmembrane transporter activity;GO:0015108|chloride transmembrane transporter activity;GO:0015116|sulfate transmembrane transporter activity;GO:0015301|anion:anion antiporter activity;GO:0019531|oxalate transmembrane transporter activity;","K13962","SLC26A7, SUT2; solute carrier family 26 (anion exchange transporter), member 7"]
["ENSRNOG00000069925",317,26.67088016,900,57.89739437,0.460657694,-1.118232986,{"v":4.346e-37,"d":"4.35E-37"},{"v":2.2515e-36,"d":"2.25E-36"},"down","yes","ENSRNOG00000069925","protein_coding","chr3:108098346-108130565:+","gi|58865490|ref|NP_001011956.1|",3337,0,"tRNA wybutosine-synthesizing protein 4 [Rattus norvegicus]","gi|323339246|gb|AC243463.5|",5101,0,"Rattus norvegicus Y Chr BAC RNAEX-201K15 (Amplicon Express Rat SHR-Akr BAC library) complete sequence","Q5XIA3",1290,0,"tRNA wybutosine-synthesizing protein 4",".",".",".",".","pfam00607","Gag_p24","gag gene protein p24 (core nucleocapsid protein). p24 forms inner protein layer of the nucleocapsid. ELISA tests for p24 is the most commonly used method to demonstrate virus replication both in vivo and in vitro.",".",".",".",".","."]
["ENSRNOG00000063040",182,15.31261889,630,40.52817606,0.3778265,-1.404204203,{"v":4.47434e-37,"d":"4.47E-37"},{"v":2.31359e-36,"d":"2.31E-36"},"down","yes","ENSRNOG00000063040","protein_coding","chr9:114137793-114149279:+","gi|564349900|ref|XP_006237777.1|",738,{"v":2e-142,"d":"2.00E-142"},"PREDICTED: zinc finger protein 431-like isoform X3 [Rattus norvegicus]","gi|672051756|ref|XR_353790.2|",713,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102550336 (LOC102550336), ncRNA","E9QAG8",303,{"v":1E-108,"d":"1.00E-108"},"Zinc finger protein 431",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000015455",269,22.63238727,805,51.78600274,0.437036768,-1.194173436,{"v":7.34713E-37,"d":"7.35E-37"},{"v":3.75977e-36,"d":"3.76E-36"},"down","yes","Spr","protein_coding","chr4:117671949-117675678:-","gi|158711683|ref|NP_062054.1|",1188,{"v":3E-160,"d":"3.00E-160"},"sepiapterin reductase [Rattus norvegicus]","gi|158711682|ref|NM_019181.1|",1195,0,"Rattus norvegicus sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) (Spr), mRNA","P18297",462,{"v":1E-161,"d":"1.00E-161"},"Sepiapterin reductase",".",".",".",".","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.","GO:0006558|L-phenylalanine metabolic process;GO:0006729|tetrahydrobiopterin biosynthetic process;GO:0006809|nitric oxide biosynthetic process;GO:0010033|response to organic substance;GO:0019889|pteridine metabolic process;GO:0040014|regulation of multicellular organism growth;GO:0042415|norepinephrine metabolic process;GO:0042417|dopamine metabolic process;GO:0042428|serotonin metabolic process;GO:0046146|tetrahydrobiopterin metabolic process;GO:0048667|cell morphogenesis involved in neuron differentiation;GO:0050882|voluntary musculoskeletal movement;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004757|sepiapterin reductase activity;GO:0042803|protein homodimerization activity;","K00072","SPR; sepiapterin reductase [EC:1.1.1.153]"]
["ENSRNOG00000017523",381,32.05553735,1017,65.42405563,0.48996561,-1.029247602,{"v":1.2225E-36,"d":"1.22E-36"},{"v":6.22085e-36,"d":"6.22E-36"},"down","yes","H6pd","protein_coding","chr5:160438697-160470171:-","gi|157821675|ref|NP_001100168.1|",4150,0,"GDH/6PGL endoplasmic bifunctional protein precursor [Rattus norvegicus]","gi|157821674|ref|NM_001106698.1|",4449,0,"Rattus norvegicus hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) (H6pd), mRNA","Q8CFX1",1524,0,"GDH/6PGL endoplasmic bifunctional protein","YNL241c",195,{"v":1E-51,"d":"1.00E-51"},"COG0364","pfam01182","Glucosamine_iso","Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase.","GO:0005975|carbohydrate metabolic process;GO:0006006|glucose metabolic process;GO:0006098|pentose-phosphate shunt;GO:0006739|NADP metabolic process;GO:0009051|pentose-phosphate shunt, oxidative branch;GO:0097305|response to alcohol;GO:2000064|regulation of cortisol biosynthetic process;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005783|endoplasmic reticulum;GO:0005788|endoplasmic reticulum lumen;GO:0016529|sarcoplasmic reticulum;GO:0043231|intracellular membrane-bounded organelle;","GO:0004345|glucose-6-phosphate dehydrogenase activity;GO:0017057|6-phosphogluconolactonase activity;GO:0030246|carbohydrate binding;GO:0050661|NADP binding;","K13937","H6PD; hexose-6-phosphate dehydrogenase [EC:1.1.1.47 3.1.1.31]"]
["ENSRNOG00000069743",77,6.478415686,389,25.02454045,0.258882504,-1.94963063,{"v":1.48512E-36,"d":"1.49E-36"},{"v":7.5221e-36,"d":"7.52E-36"},"down","yes","Nxpe5l1","protein_coding","chr12:17186134-17196403:+","gi|672072443|ref|XP_008767296.1|",2942,0,"PREDICTED: NXPE family member 3-like isoform X2 [Rattus norvegicus]","gi|672072442|ref|XM_008769074.1|",1656,0,"PREDICTED: Rattus norvegicus neurexophilin and PC-esterase domain family, member 5 (Nxpe5), transcript variant X2, mRNA","A2VDP6",328,{"v":7e-103,"d":"7.00E-103"},"NXPE family member 3",".",".",".",".","pfam06312","Neurexophilin","Neurexophilin. This family consists of mammalian neurexophilin proteins. Mammalian brains contain four different neurexophilin proteins. Neurexophilins form a family of related glycoproteins that are proteolytically processed after synthesis and bind to alpha-neurexins. The structure and characteristics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins.",".",".",".",".","."]
["ENSRNOG00000030447",340,28.60599134,937,60.27762058,0.474570679,-1.075305127,{"v":2.79653e-36,"d":"2.80E-36"},{"v":1.40857e-35,"d":"1.41E-35"},"down","yes","AC105662.1","protein_coding","chr5:166300122-166310326:+","gi|109475928|ref|XP_001058198.1|",856,{"v":1e-104,"d":"1.00E-104"},"PREDICTED: fibronectin type-III domain-containing transmembrane protein C1orf233 homolog [Rattus norvegicus]","gi|672055112|ref|XM_001058198.5|",1593,0,"PREDICTED: Rattus norvegicus hypothetical protein LOC680656 (LOC680656), transcript variant X2, mRNA","D4A2Q0",334,{"v":3e-106,"d":"3.00E-106"},"Fibronectin type III domain-containing protein 10","YJL190c",207,{"v":3e-61,"d":"3.00E-61"},"COG0096","pfam00410","Ribosomal_S8","Ribosomal protein S8.","GO:0006412|translation;",".",".",".","."]
["ENSRNOG00000052613",362,30.45696725,976,62.78650767,0.485087774,-1.043682276,{"v":5.25542e-36,"d":"5.26E-36"},{"v":2.62282e-35,"d":"2.62E-35"},"down","yes","Casp6","protein_coding","chr2:218466076-218478502:+","gi|564338718|ref|XP_006233340.1|",1423,0,"PREDICTED: caspase-6 isoform X2 [Rattus norvegicus]","gi|430768614|ref|NM_031775.3|",1570,0,"Rattus norvegicus caspase 6 (Casp6), transcript variant 1, mRNA","O35397",543,0,"Caspase-6",".",".",".",".","pfam00656","Peptidase_C14","Caspase domain.","GO:0002088|lens development in camera-type eye;GO:0002525|acute inflammatory response to non-antigenic stimulus;GO:0006508|proteolysis;GO:0006915|apoptotic process;GO:0007413|axonal fasciculation;GO:0009408|response to heat;GO:0009749|response to glucose;GO:0010033|response to organic substance;GO:0010038|response to metal ion;GO:0010039|response to iron ion;GO:0010243|response to organonitrogen compound;GO:0010332|response to gamma radiation;GO:0030855|epithelial cell differentiation;GO:0032355|response to estradiol;GO:0033574|response to testosterone;GO:0034097|response to cytokine;GO:0042542|response to hydrogen peroxide;GO:0043065|positive regulation of apoptotic process;GO:0043525|positive regulation of neuron apoptotic process;GO:0046670|positive regulation of retinal cell programmed cell death;GO:0072734|cellular response to staurosporine;GO:0097194|execution phase of apoptosis;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0030424|axon;GO:0043025|neuronal cell body;","GO:0004175|endopeptidase activity;GO:0004197|cysteine-type endopeptidase activity;GO:0042802|identical protein binding;GO:0097153|cysteine-type endopeptidase activity involved in apoptotic process;GO:0097200|cysteine-type endopeptidase activity involved in execution phase of apoptosis;","K04396","CASP6; caspase 6 [EC:3.4.22.59]"]
["ENSRNOG00000042536",86,7.235633104,408,26.24681878,0.275676575,-1.858951413,{"v":5.36493e-36,"d":"5.36E-36"},{"v":2.67502e-35,"d":"2.68E-35"},"down","yes","Pde4d","protein_coding","chr2:40019933-41525884:+","gi|568984459|ref|XP_006517708.1|",3690,0,"PREDICTED: cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X3 [Mus musculus]","gi|880862234|ref|XM_005065552.2|",2896,0,"PREDICTED: Mesocricetus auratus phosphodiesterase 4D, cAMP-specific (Pde4d), transcript variant X4, mRNA","P14270",1331,0,"cAMP-specific 3',5'-cyclic phosphodiesterase 4D",".",".",".",".","pfam00233","PDEase_I","3'5'-cyclic nucleotide phosphodiesterase.","GO:0001934|positive regulation of protein phosphorylation;GO:0002027|regulation of heart rate;GO:0006198|cAMP catabolic process;GO:0006939|smooth muscle contraction;GO:0007165|signal transduction;GO:0007568|aging;GO:0007613|memory;GO:0008277|regulation of G protein-coupled receptor signaling pathway;GO:0010469|regulation of signaling receptor activity;GO:0010880|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0014911|positive regulation of smooth muscle cell migration;GO:0022409|positive regulation of cell-cell adhesion;GO:0030324|lung development;GO:0030593|neutrophil chemotaxis;GO:0032729|positive regulation of interferon-gamma production;GO:0032743|positive regulation of interleukin-2 production;GO:0032754|positive regulation of interleukin-5 production;GO:0033137|negative regulation of peptidyl-serine phosphorylation;GO:0034622|cellular protein-containing complex assembly;GO:0035264|multicellular organism growth;GO:0043949|regulation of cAMP-mediated signaling;GO:0043951|negative regulation of cAMP-mediated signaling;GO:0045822|negative regulation of heart contraction;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0050852|T cell receptor signaling pathway;GO:0050900|leukocyte migration;GO:0060314|regulation of ryanodine-sensitive calcium-release channel activity;GO:0061028|establishment of endothelial barrier;GO:0071222|cellular response to lipopolysaccharide;GO:0071320|cellular response to cAMP;GO:0071872|cellular response to epinephrine stimulus;GO:0071875|adrenergic receptor signaling pathway;GO:0086004|regulation of cardiac muscle cell contraction;GO:0086024|adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate;GO:1901898|negative regulation of relaxation of cardiac muscle;","GO:0005634|nucleus;GO:0005794|Golgi apparatus;GO:0005813|centrosome;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005891|voltage-gated calcium channel complex;GO:0016020|membrane;GO:0016324|apical plasma membrane;GO:0030016|myofibril;GO:0032991|protein-containing complex;GO:0034704|calcium channel complex;GO:0034705|potassium channel complex;GO:0048471|perinuclear region of cytoplasm;","GO:0004112|cyclic-nucleotide phosphodiesterase activity;GO:0004114|3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0004115|3',5'-cyclic-AMP phosphodiesterase activity;GO:0005515|protein binding;GO:0019899|enzyme binding;GO:0030552|cAMP binding;GO:0031698|beta-2 adrenergic receptor binding;GO:0044325|ion channel binding;GO:0046872|metal ion binding;GO:0051117|ATPase binding;GO:0097110|scaffold protein binding;GO:1901363|heterocyclic compound binding;","K13293","PDE4; cAMP-specific phosphodiesterase 4 [EC:3.1.4.53]"]
["ENSRNOG00000000653",266,22.37998146,792,50.94970704,0.439256333,-1.18686501,{"v":5.87578e-36,"d":"5.88E-36"},{"v":2.92171e-35,"d":"2.92E-35"},"down","yes","Nr5a2","protein_coding","chr13:48316301-48433326:-","gi|13492975|ref|NP_068510.1|",2876,0,"nuclear receptor subfamily 5 group A member 2 [Rattus norvegicus]","gi|13492974|ref|NM_021742.1|",1928,0,"Rattus norvegicus nuclear receptor subfamily 5, group A, member 2 (Nr5a2), mRNA","Q9QWM1",1112,0,"Nuclear receptor subfamily 5 group A member 2",".",".",".",".","pfam00105","zf-C4","Zinc finger, C4 type (two domains). In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.","GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008206|bile acid metabolic process;GO:0009755|hormone-mediated signaling pathway;GO:0009888|tissue development;GO:0030522|intracellular receptor signaling pathway;GO:0030855|epithelial cell differentiation;GO:0042127|regulation of cell proliferation;GO:0042632|cholesterol homeostasis;GO:0045070|positive regulation of viral genome replication;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0061113|pancreas morphogenesis;GO:0097720|calcineurin-mediated signaling;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0090575|RNA polymerase II transcription factor complex;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003690|double-stranded DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0004879|nuclear receptor activity;GO:0005543|phospholipid binding;GO:0008270|zinc ion binding;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K08027","NR5A2, FTF; nuclear receptor subfamily 5 group A member 2"]
["ENSRNOG00000017154",359,30.20456144,969,62.3361946,0.484542915,-1.045303647,{"v":7.5841E-36,"d":"7.58E-36"},{"v":3.76429E-35,"d":"3.76E-35"},"down","yes","Atp11a","protein_coding","chr16:76657752-76767640:-","gi|189163522|ref|NP_001100794.2|",6056,0,"probable phospholipid-transporting ATPase IH [Rattus norvegicus]","gi|189163521|ref|NM_001107324.2|",7459,0,"Rattus norvegicus ATPase phospholipid transporting 11A (Atp11a), mRNA","P98197",2290,0,"Probable phospholipid-transporting ATPase IH","YAL026c",585,{"v":3E-176,"d":"3.00E-176"},"COG0474","pfam13246","Hydrolase_like2","Putative hydrolase of sodium-potassium ATPase alpha subunit. This is a putative hydrolase of the sodium-potassium ATPase alpha subunit.","GO:0001701|in utero embryonic development;GO:0010831|positive regulation of myotube differentiation;GO:0045332|phospholipid translocation;","GO:0005783|endoplasmic reticulum;GO:0005802|trans-Golgi network;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0055037|recycling endosome;GO:1990531|phospholipid-translocating ATPase complex;","GO:0000287|magnesium ion binding;GO:0005524|ATP binding;GO:0090555|phosphatidylethanolamine-translocating ATPase activity;","K01530","E7.6.2.1; phospholipid-translocating ATPase [EC:7.6.2.1]"]
["ENSRNOG00000053163",186,15.64915997,629,40.46384562,0.386744258,-1.370548221,{"v":9.64733e-36,"d":"9.65E-36"},{"v":4.77964e-35,"d":"4.78E-35"},"down","yes","AABR07050084.1","snoRNA","chr5:144505211-144505346:+",".",".",".",".","gi|908662240|tpe|LN871982.1|",111,{"v":6e-50,"d":"6.00E-50"},"TPA: Mus musculus SNORA16 (ACA16) gene for small nucleolar RNA SNORA16 (ACA16)",".",".",".",".",".",".",".",".","pfam14026","DUF4242","Protein of unknown function (DUF4242). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 90 and 170 amino acids in length. There is a single completely conserved residue C that may be functionally important.",".",".",".",".","."]
["ENSRNOG00000001833",267,22.46411673,792,50.94970704,0.440907672,-1.181451514,{"v":1.04002e-35,"d":"1.04E-35"},{"v":5.14795e-35,"d":"5.15E-35"},"down","yes","Mcm4","protein_coding","chr11:85258443-85272144:+","gi|274321177|ref|NP_387500.1|",4009,0,"DNA replication licensing factor MCM4 [Rattus norvegicus]","gi|672071695|ref|XR_358443.2|",2772,0,"PREDICTED: Rattus norvegicus minichromosome maintenance complex component 4 (Mcm4), transcript variant X1, misc_RNA","P49717",1518,0,"DNA replication licensing factor MCM4","YPR019w",646,0,"COG1241","pfam00493","MCM","MCM2/3/5 family.","GO:0000727|double-strand break repair via break-induced replication;GO:0006268|DNA unwinding involved in DNA replication;GO:0006271|DNA strand elongation involved in DNA replication;GO:1902975|mitotic DNA replication initiation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005694|chromosome;GO:0042555|MCM complex;","GO:0003678|DNA helicase activity;GO:0003697|single-stranded DNA binding;GO:0005524|ATP binding;GO:0017116|single-stranded DNA-dependent ATP-dependent DNA helicase activity;","K02212","MCM4, CDC54; DNA replication licensing factor MCM4 [EC:5.6.2.3]"]
["ENSRNOG00000018845",330,27.76463865,908,58.41203787,0.475323917,-1.073017098,{"v":4.29129e-35,"d":"4.29E-35"},{"v":2.10499e-34,"d":"2.10E-34"},"down","yes","Snapc4","protein_coding","chr3:9182067-9199518:-","gi|392346158|ref|XP_003749474.1|",5417,0,"PREDICTED: snRNA-activating protein complex subunit 4 isoform X2 [Rattus norvegicus]","gi|672044827|ref|XM_003749426.3|",4350,0,"PREDICTED: Rattus norvegicus small nuclear RNA activating complex, polypeptide 4 (Snapc4), transcript variant X2, mRNA","Q8BP86",1761,0,"snRNA-activating protein complex subunit 4","YKR099w",89.7,{"v":4e-17,"d":"4.00E-17"},"COG5147","pfam13921","Myb_DNA-bind_6","Myb-like DNA-binding domain. This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.","GO:0008150|biological_process;GO:0042795|snRNA transcription by RNA polymerase II;GO:0042796|snRNA transcription by RNA polymerase III;","GO:0005575|cellular_component;GO:0019185|snRNA-activating protein complex;","GO:0000995|RNA polymerase III general transcription initiation factor activity;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0016251|RNA polymerase II general transcription initiation factor activity;","K09453","SNAPC4; snRNA-activating protein complex subunit 4"]
["ENSRNOG00000047867",171,14.38713094,592,38.08361941,0.377777406,-1.404391676,{"v":5.98693e-35,"d":"5.99E-35"},{"v":2.92358e-34,"d":"2.92E-34"},"down","yes","Klhdc8b","protein_coding","chr8:109141594-109146918:-","gi|56090355|ref|NP_001007686.1|",1334,{"v":8e-173,"d":"8.00E-173"},"kelch domain-containing protein 8B [Rattus norvegicus]","gi|672062958|ref|XM_008766516.1|",1882,0,"PREDICTED: Rattus norvegicus kelch domain containing 8B (Klhdc8b), transcript variant X1, mRNA","Q5XIA9",518,{"v":2E-174,"d":"2.00E-174"},"Kelch domain-containing protein 8B",".",".",".",".","pfam01344","Kelch_1","Kelch motif. The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that the Drosophila ring canal kelch protein is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.","GO:0098813|nuclear chromosome segregation;GO:0140014|mitotic nuclear division;GO:1902410|mitotic cytokinetic process;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0030496|midbody;GO:0045171|intercellular bridge;GO:0110070|cellularization cleavage furrow;",".",".","."]
["ENSRNOG00000069713",323,27.17569177,893,57.4470813,0.473056092,-1.079916836,{"v":6.91794e-35,"d":"6.92E-35"},{"v":3.37217e-34,"d":"3.37E-34"},"down","yes","ENSRNOG00000069713","lncRNA","chrX:15395785-15398610:-","gi|149061698|gb|EDM12121.1|",421,{"v":5e-45,"d":"5.00E-45"},"rCG47580, partial [Rattus norvegicus]","gi|228480382|gb|AC122990.5|",1389,0,"Rattus norvegicus CH230-360O12 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P10273",129,{"v":1e-40,"d":"1.00E-40"},"Gag-Pol polyprotein",".",".",".",".","pfam00429","TLV_coat","ENV polyprotein (coat polyprotein).",".",".",".",".","."]
["ENSRNOG00000018615",79,6.646686223,384,24.70288826,0.269065145,-1.893972578,{"v":8.38224e-35,"d":"8.38E-35"},{"v":4.075e-34,"d":"4.08E-34"},"down","yes","Cenph","protein_coding","chr2:31894667-31910154:-","gi|672041340|ref|XP_008758923.1|",1138,{"v":2e-144,"d":"2.00E-144"},"PREDICTED: centromere protein H isoform X1 [Rattus norvegicus]","gi|672041339|ref|XM_008760701.1|",1187,0,"PREDICTED: Rattus norvegicus similar to centromere autoantigen H (LOC681185), transcript variant X1, mRNA","Q9QYM8",360,{"v":2e-114,"d":"2.00E-114"},"Centromere protein H",".",".",".",".","pfam05837","CENP-H","Centromere protein H (CENP-H). This family consists of several eukaryotic centromere protein H (CENP-H) sequences. Macromolecular centromere-kinetochore complex plays a critical role in sister chromatid separation, but its complete protein composition as well as its precise dynamic function during mitosis has not yet been clearly determined. CENP-H contains a coiled-coil structure and a nuclear localisation signal. CENP-H is specifically and constitutively localized in kinetochores throughout the cell cycle. CENP-H may play a role in kinetochore organisation and function throughout the cell cycle. This the C-terminus of the region, which is conserved from fungi to humans.","GO:0007052|mitotic spindle organization;GO:0007059|chromosome segregation;GO:0051382|kinetochore assembly;","GO:0000776|kinetochore;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005694|chromosome;GO:0005730|nucleolus;","GO:0043515|kinetochore binding;","K11500","CENPH; centromere protein H"]
["ENSRNOG00000033658",133,11.18999073,508,32.6798626,0.342412417,-1.546193077,{"v":1.2622E-34,"d":"1.26E-34"},{"v":6.10343e-34,"d":"6.10E-34"},"down","yes","Kntc1","protein_coding","chr12:32769020-32839561:-","gi|672072960|ref|XP_008767450.1|",11399,0,"PREDICTED: kinetochore-associated protein 1 isoform X1 [Rattus norvegicus]","gi|672072959|ref|XM_008769228.1|",6944,0,"PREDICTED: Rattus norvegicus kinetochore associated 1 (Kntc1), transcript variant X1, mRNA","Q8C3Y4",4054,0,"Kinetochore-associated protein 1",".",".",".",".","pfam10493","Rod_C","Rough deal protein C-terminal region. Rod, the Rough deal protein, displays a dynamic intracellular staining pattern, localizing first to kinetochores in pro-metaphase, but moving to kinetochore microtubules at metaphase. Early in anaphase the protein is once again restricted to the kinetochores, where it persists until the end of telophase. This behaviour is in all respects similar to that described for ZW10, and indeed the two proteins function together, localisation of each depending upon the other. These two proteins are found at the kinetochore in complex with a third, Zwilch, in both flies and humans. The C-terminus is the most conserved part of the protein. During pro-metaphase, the ZW10-Rod complex, dynein/dynactin, and Mad2 all accumulate on unattached kinetochores; microtubule capture leads to Mad2 depletion as it is carried off by dynein/dynactin; ZW10-Rod complex accumulation continues, replenishing kinetochore dynein. The continuing recruitment of the ZW10-Rod complex during metaphase may serve to maintain adequate dynein/dynactin complex on kinetochores for assisting chromatid movement during anaphase. The ZW10-Rod complex acts as a bridge whose association with Zwint-1 links Mad1 and Mad2, components that are directly responsible for generating the diffusible 'wait anaphase' signal, to a structural, inner kinetochore complex containing Mis12 and KNL-1AF15q14, the last of which has been proved to be essential for kinetochore assembly in C. elegans. Removal of ZW10 or Rod inactivates the mitotic checkpoint.","GO:0000070|mitotic sister chromatid segregation;GO:0007094|mitotic spindle assembly checkpoint;GO:1903394|protein localization to kinetochore involved in kinetochore assembly;","GO:0000922|spindle pole;GO:0005737|cytoplasm;GO:0005828|kinetochore microtubule;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0015629|actin cytoskeleton;GO:1990423|RZZ complex;","GO:0031267|small GTPase binding;","K11577","KNTC1, ROD; kinetochore-associated protein 1"]
["ENSRNOG00000056651",233,19.60351759,716,46.06059374,0.425602798,-1.232420458,{"v":1.43311E-34,"d":"1.43E-34"},{"v":6.91759e-34,"d":"6.92E-34"},"down","yes","ENSRNOG00000056651","protein_coding","chr1:84549831-84550664:-","gi|293355807|ref|XP_002728770.1|",222,{"v":7e-20,"d":"7.00E-20"},"PREDICTED: immortalization up-regulated protein-like [Rattus norvegicus]","gi|298886976|emb|FQ220383.1|",347,{"v":2E-180,"d":"2.00E-180"},"Rattus norvegicus TL0ADA43YB16 mRNA sequence",".",".",".",".",".",".",".",".","pfam07188","KSHV_K8","Kaposi's sarcoma-associated herpesvirus (KSHV) K8 protein. This family consists of Kaposi's sarcoma-associated herpesvirus (KSHV) K8 proteins. KSHV is a human Gammaherpesvirus related to Epstein-Barr virus (EBV) and herpesvirus saimiri. KSHV open reading frame K8 encodes a basic region-leucine zipper protein of 237 aa that homodimerises. K8 interacts and co-localizes with human pfam04855, a cellular chromatin-remodelling factor, both in vivo and in vitro. K8 is thought to function as a transcriptional activator under specific conditions and its transactivation activity requires its interaction with the cellular chromatin remodelling factor hSNF5.",".","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005829|cytosol;GO:0005886|plasma membrane;",".",".","."]
["ENSRNOG00000006403",282,23.72614576,807,51.91466362,0.457022046,-1.129664336,{"v":5.89309e-34,"d":"5.89E-34"},{"v":2.8048E-33,"d":"2.80E-33"},"down","yes","Nectin1","protein_coding","chr8:44101776-44189787:+","gi|148693608|gb|EDL25555.1|",2470,0,"poliovirus receptor-related 1, isoform CRA_a, partial [Mus musculus]","gi|747165385|ref|NM_001100476.1|",5664,0,"Rattus norvegicus poliovirus receptor-related 1 (Pvrl1), mRNA","Q9JKF6",929,0,"Nectin-1",".",".",".",".","pfam08205","C2-set_2","CD80-like C2-set immunoglobulin domain. These domains belong to the immunoglobulin superfamily.","GO:0002089|lens morphogenesis in camera-type eye;GO:0002934|desmosome organization;GO:0006826|iron ion transport;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007411|axon guidance;GO:0019062|virion attachment to host cell;GO:0046598|positive regulation of viral entry into host cell;GO:0046718|viral entry into host cell;GO:0048593|camera-type eye morphogenesis;GO:0051963|regulation of synapse assembly;GO:0060041|retina development in camera-type eye;GO:0070166|enamel mineralization;GO:0098609|cell-cell adhesion;GO:1902414|protein localization to cell junction;","GO:0005886|plasma membrane;GO:0005912|adherens junction;GO:0030424|axon;GO:0030425|dendrite;GO:0032584|growth cone membrane;GO:0043005|neuron projection;GO:0043231|intracellular membrane-bounded organelle;GO:0043296|apical junction complex;GO:0044291|cell-cell contact zone;GO:0045202|synapse;GO:0098686|hippocampal mossy fiber to CA3 synapse;GO:0099059|integral component of presynaptic active zone membrane;","GO:0005515|protein binding;GO:0030246|carbohydrate binding;GO:0038023|signaling receptor activity;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0044877|protein-containing complex binding;GO:0046790|virion binding;GO:0050839|cell adhesion molecule binding;","K06081","NECTIN1, PVRL1, CD111; poliovirus receptor-related protein 1"]
["ENSRNOG00000001517",152,12.78856083,544,34.99575837,0.365431739,-1.452326153,{"v":7.7661e-34,"d":"7.77E-34"},{"v":3.67697e-33,"d":"3.68E-33"},"down","yes","Pdk1","protein_coding","chr3:56705871-56733038:+","gi|59709473|ref|NP_446278.2|",2153,0,"pyruvate dehydrogenase kinase, isozyme 1 precursor [Rattus norvegicus]","gi|59709472|ref|NM_053826.2|",1579,0,"Rattus norvegicus pyruvate dehydrogenase kinase 1 (Pdk1), mRNA","Q63065",832,0,"[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial","SPAC644.11c",196,{"v":1e-55,"d":"1.00E-55"},"COG0642","pfam10436","BCDHK_Adom3","Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase. Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal.","GO:0006006|glucose metabolic process;GO:0006468|protein phosphorylation;GO:0007166|cell surface receptor signaling pathway;GO:0008283|cell proliferation;GO:0008631|intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0010510|regulation of acetyl-CoA biosynthetic process from pyruvate;GO:0010906|regulation of glucose metabolic process;GO:0018105|peptidyl-serine phosphorylation;GO:0097411|hypoxia-inducible factor-1alpha signaling pathway;","GO:0005739|mitochondrion;GO:0005967|mitochondrial pyruvate dehydrogenase complex;GO:0045254|pyruvate dehydrogenase complex;","GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0004740|pyruvate dehydrogenase (acetyl-transferring) kinase activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;","K12077","PDK1; pyruvate dehydrogenase kinase isoform 1 [EC:2.7.11.2]"]
["ENSRNOG00000011910",310,26.08193328,857,55.13118552,0.473088562,-1.079817814,{"v":1.5229E-33,"d":"1.52E-33"},{"v":7.14208e-33,"d":"7.14E-33"},"down","yes","Hnrnpr","protein_coding","chr5:148543044-148574867:+","gi|521031535|gb|EPQ13321.1|",2187,0,"Heterogeneous nuclear ribonucleoprotein R [Myotis brandtii]","gi|62990188|ref|NM_175603.2|",2605,0,"Rattus norvegicus heterogeneous nuclear ribonucleoprotein R (Hnrnpr), mRNA","O43390",845,0,"Heterogeneous nuclear ribonucleoprotein R",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0007623|circadian rhythm;GO:0043086|negative regulation of catalytic activity;GO:0061014|positive regulation of mRNA catabolic process;GO:0061157|mRNA destabilization;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0030425|dendrite;GO:0030426|growth cone;GO:0043679|axon terminus;GO:0071013|catalytic step 2 spliceosome;GO:1990904|ribonucleoprotein complex;","GO:0003723|RNA binding;GO:0003729|mRNA binding;GO:0003730|mRNA 3'-UTR binding;","K13161","HNRNPR; heterogeneous nuclear ribonucleoprotein R"]
["ENSRNOG00000054549",360,30.28869671,950,61.11391628,0.495610469,-1.012721432,{"v":1.76571e-33,"d":"1.77E-33"},{"v":8.26655e-33,"d":"8.27E-33"},"down","yes","Lss","protein_coding","chr20:12092774-12118762:-","gi|149043692|gb|EDL97143.1|",3520,0,"rCG60576, isoform CRA_a [Rattus norvegicus]","gi|639864|dbj|D45252.1|RAT23OLC",2024,0,"Rattus norvegicus mRNA for 2,3-oxidosqualene:lanosterol cyclase, complete cds","P48450",1355,0,"Lanosterol synthase","YHR072w",464,{"v":3e-143,"d":"3.00E-143"},"COG1657","pfam00432","Prenyltrans","Prenyltransferase and squalene oxidase repeat.","GO:0006694|steroid biosynthetic process;GO:0006695|cholesterol biosynthetic process;GO:0016104|triterpenoid biosynthetic process;GO:0016125|sterol metabolic process;GO:0031647|regulation of protein stability;","GO:0005789|endoplasmic reticulum membrane;GO:0005811|lipid droplet;GO:0043231|intracellular membrane-bounded organelle;","GO:0000250|lanosterol synthase activity;GO:0042300|beta-amyrin synthase activity;","K01852","LSS, ERG7; lanosterol synthase [EC:5.4.99.7]"]
["ENSRNOG00000028390",128,10.76931439,489,31.45758427,0.342343973,-1.54648148,{"v":2.10878E-33,"d":"2.11E-33"},{"v":9.85576e-33,"d":"9.86E-33"},"down","yes","Hhipl1","protein_coding","chr6:127220014-127242564:+","gi|293360094|ref|XP_343108.4|",3608,0,"PREDICTED: HHIP-like protein 1 [Rattus norvegicus]","gi|672057077|ref|XM_343107.7|",3643,0,"PREDICTED: Rattus norvegicus HHIP-like 1 (Hhipl1), mRNA","Q14DK5",1319,0,"HHIP-like protein 1","slr1608",87.4,{"v":4e-17,"d":"4.00E-17"},"COG2133","pfam00530","SRCR","Scavenger receptor cysteine-rich domain. These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.","GO:0006897|endocytosis;","GO:0016020|membrane;","GO:0003824|catalytic activity;GO:0005044|scavenger receptor activity;","K25557","HHIPL; HHIP-like protein"]
["ENSRNOG00000004736",221,18.59389437,681,43.8090284,0.424430649,-1.236399254,{"v":4.02178e-33,"d":"4.02E-33"},{"v":1.87162e-32,"d":"1.87E-32"},"down","yes","Ralgps2","protein_coding","chr13:68928474-69056549:-","gi|524937446|ref|XP_005071372.1|",2837,0,"PREDICTED: ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1 [Mesocricetus auratus]","gi|880889145|ref|XM_005071315.2|",1987,0,"PREDICTED: Mesocricetus auratus Ral GEF with PH domain and SH3 binding motif 2 (Ralgps2), transcript variant X1, mRNA","Q86X27",1092,0,"Ras-specific guanine nucleotide-releasing factor RalGPS2",".",".",".",".","pfam00617","RasGEF","RasGEF domain. Guanine nucleotide exchange factor for Ras-like small GTPases.","GO:0007264|small GTPase mediated signal transduction;GO:0032485|regulation of Ral protein signal transduction;GO:0050790|regulation of catalytic activity;",".","GO:0005085|guanyl-nucleotide exchange factor activity;","K24023","RALGPS; Ras-specific guanine nucleotide-releasing factor RalGPS"]
["ENSRNOG00000016245",70,5.889468805,352,22.64431424,0.260085986,-1.942939427,{"v":4.26725e-33,"d":"4.27E-33"},{"v":1.98416E-32,"d":"1.98E-32"},"down","yes","Neto2","protein_coding","chr19:21344289-21417023:+","gi|148679073|gb|EDL11020.1|",2780,0,"mCG14322, isoform CRA_b, partial [Mus musculus]","gi|755527350|ref|XM_006531439.2|",2432,0,"PREDICTED: Mus musculus neuropilin (NRP) and tolloid (TLL)-like 2 (Neto2), transcript variant X3, mRNA","C6K2K4",1032,0,"Neuropilin and tolloid-like protein 2",".",".",".",".","pfam00431","CUB","CUB domain.","GO:2000312|regulation of kainate selective glutamate receptor activity;","GO:0014069|postsynaptic density;GO:0016021|integral component of membrane;GO:0045202|synapse;","GO:0035255|ionotropic glutamate receptor binding;","K24360","NETO; neuropilin and tolloid-like protein"]
["ENSRNOG00000016623",78,6.562550954,370,23.80226213,0.275711229,-1.858770067,{"v":8.47285e-33,"d":"8.47E-33"},{"v":3.90705e-32,"d":"3.91E-32"},"down","yes","Tmeff2","protein_coding","chr9:50436079-50733475:-","gi|157818059|ref|NP_001102265.1|",1388,0,"tomoregulin-2 [Rattus norvegicus]","gi|157818058|ref|NM_001108795.1|",3252,0,"Rattus norvegicus transmembrane protein with EGF-like and two follistatin-like domains 2 (Tmeff2), mRNA","Q9UIK5",488,0,"Tomoregulin-2",".",".",".",".","pfam07648","Kazal_2","Kazal-type serine protease inhibitor domain. Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.","GO:0008150|biological_process;GO:0009887|animal organ morphogenesis;GO:0009888|tissue development;GO:0016477|cell migration;GO:0030336|negative regulation of cell migration;GO:0034446|substrate adhesion-dependent cell spreading;GO:0044319|wound healing, spreading of cells;GO:0045720|negative regulation of integrin biosynthetic process;GO:0051497|negative regulation of stress fiber assembly;","GO:0005575|cellular_component;GO:0005604|basement membrane;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;","K23608","TMEFF2; tomoregulin-2"]
["ENSRNOG00000006469",306,25.74539221,843,54.23055939,0.474739566,-1.074791804,{"v":8.70728e-33,"d":"8.71E-33"},{"v":4.01098e-32,"d":"4.01E-32"},"down","yes","Cdk2","protein_coding","chr7:1129811-1137403:-","gi|537270011|gb|ERE91712.1|",1870,0,"cyclin-dependent kinase 2 [Cricetulus griseus]","gi|564357814|ref|XM_006240778.1|",2375,0,"PREDICTED: Rattus norvegicus cyclin dependent kinase 2 (Cdk2), transcript variant X1, mRNA","P97377",716,0,"Cyclin-dependent kinase 2",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0000082|G1/S transition of mitotic cell cycle;GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0002088|lens development in camera-type eye;GO:0006281|DNA repair;GO:0006468|protein phosphorylation;GO:0006813|potassium ion transport;GO:0007099|centriole replication;GO:0007165|signal transduction;GO:0007265|Ras protein signal transduction;GO:0008284|positive regulation of cell proliferation;GO:0009410|response to xenobiotic stimulus;GO:0009636|response to toxic substance;GO:0010389|regulation of G2/M transition of mitotic cell cycle;GO:0010468|regulation of gene expression;GO:0016572|histone phosphorylation;GO:0018105|peptidyl-serine phosphorylation;GO:0031100|animal organ regeneration;GO:0032298|positive regulation of DNA-dependent DNA replication initiation;GO:0032355|response to estradiol;GO:0032869|cellular response to insulin stimulus;GO:0045471|response to ethanol;GO:0045893|positive regulation of transcription, DNA-templated;GO:0046686|response to cadmium ion;GO:0051301|cell division;GO:0051321|meiotic cell cycle;GO:0051591|response to cAMP;GO:0051602|response to electrical stimulus;GO:0051726|regulation of cell cycle;GO:0060968|regulation of gene silencing;GO:1903363|negative regulation of cellular protein catabolic process;GO:1904146|positive regulation of meiotic cell cycle process involved in oocyte maturation;","GO:0000307|cyclin-dependent protein kinase holoenzyme complex;GO:0000781|chromosome, telomeric region;GO:0000793|condensed chromosome;GO:0000805|X chromosome;GO:0000806|Y chromosome;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005813|centrosome;GO:0005815|microtubule organizing center;GO:0005829|cytosol;GO:0015030|Cajal body;GO:0043231|intracellular membrane-bounded organelle;GO:0097123|cyclin A1-CDK2 complex;GO:0097124|cyclin A2-CDK2 complex;GO:0097134|cyclin E1-CDK2 complex;GO:0097135|cyclin E2-CDK2 complex;","GO:0000287|magnesium ion binding;GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0004693|cyclin-dependent protein serine/threonine kinase activity;GO:0005524|ATP binding;GO:0016301|kinase activity;GO:0019904|protein domain specific binding;GO:0030332|cyclin binding;GO:0035173|histone kinase activity;GO:0044877|protein-containing complex binding;GO:0097472|cyclin-dependent protein kinase activity;","K02206","CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]"]
["ENSRNOG00000021478",107,9.002473745,438,28.17673192,0.31950028,-1.646110898,{"v":8.83071e-33,"d":"8.83E-33"},{"v":4.0644e-32,"d":"4.06E-32"},"down","yes","Tpd52l1","protein_coding","chr1:26172170-26291109:+","gi|112983804|ref|NP_001037760.1|",859,{"v":8e-110,"d":"8.00E-110"},"tumor protein D53 [Rattus norvegicus]","gi|672034060|ref|XM_006227737.2|",1571,0,"PREDICTED: Rattus norvegicus tumor protein D52-like 1 (Tpd52l1), transcript variant X2, mRNA","O54818",298,{"v":2e-96,"d":"2.00E-96"},"Tumor protein D53",".",".",".",".","pfam04201","TPD52","tumor protein D52 family. The hD52 gene was originally identified through its elevated expression level in human breast carcinoma. Cloning of D52 homologues from other species has indicated that D52 may play roles in calcium-mediated signal transduction and cell proliferation. Two human homologues of hD52, hD53 and hD54, have also been identified, demonstrating the existence of a novel gene/protein family. These proteins have an amino terminal coiled-coil that allows members to form homo- and heterodimers with each other.","GO:0000086|G2/M transition of mitotic cell cycle;GO:0043406|positive regulation of MAP kinase activity;GO:0046330|positive regulation of JNK cascade;GO:2001235|positive regulation of apoptotic signaling pathway;","GO:0005737|cytoplasm;GO:0048471|perinuclear region of cytoplasm;","GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;",".","."]
["ENSRNOG00000005266",20,1.682705373,210,13.50939202,0.124558187,-3.005108248,{"v":1.04234E-32,"d":"1.04E-32"},{"v":4.7853e-32,"d":"4.79E-32"},"down","yes","Amdhd1","protein_coding","chr7:28043716-28059156:-","gi|300796311|ref|NP_001178710.1|",2143,0,"probable imidazolonepropionase [Rattus norvegicus]","gi|300796310|ref|NM_001191781.1|",1290,0,"Rattus norvegicus amidohydrolase domain containing 1 (Amdhd1), mRNA","Q9DBA8",776,0,"Probable imidazolonepropionase","FN0740",234,{"v":5e-70,"d":"5.00E-70"},"COG1228","pfam13147","Amidohydro_4","Amidohydrolase. This family of enzymes are a part of a large metal dependent hydrolase superfamily. The family includes Adenine deaminase EC:3.5.4.2 that hydrolyses adenine to form hypoxanthine and ammonia. Adenine deaminases reaction is important for adenine utilisation as a purine and also as a nitrogen source. This family also includes dihydroorotase and N-acetylglucosamine-6-phosphate deacetylases, EC:3.5.1.25 These enzymes catalyse the reaction N-acetyl-D-glucosamine 6-phosphate + H2O <=> D-glucosamine 6-phosphate + acetate. This family includes the catalytic domain of urease alpha subunit. Dihydroorotases (EC:3.5.2.3) are also included.","GO:0006548|histidine catabolic process;GO:0019556|histidine catabolic process to glutamate and formamide;GO:0019557|histidine catabolic process to glutamate and formate;","GO:0005737|cytoplasm;","GO:0050480|imidazolonepropionase activity;","K01468","hutI, AMDHD1; imidazolonepropionase [EC:3.5.2.7]"]
["ENSRNOG00000006037",10,0.841352686,174,11.19349624,0.075164423,-3.733806226,{"v":1.64077E-32,"d":"1.64E-32"},{"v":7.48846e-32,"d":"7.49E-32"},"down","yes","Snap25","protein_coding","chr3:124041898-124123760:+","gi|537150988|gb|ERE71496.1|",1122,{"v":4e-146,"d":"4.00E-146"},"synaptosomal-associated protein 25 [Cricetulus griseus]","gi|396080313|ref|NM_001270575.1|",2103,0,"Rattus norvegicus synaptosomal-associated protein 25 (Snap25), transcript variant 1, mRNA","P60881",398,{"v":3e-133,"d":"3.00E-133"},"Synaptosomal-associated protein 25",".",".",".",".","pfam05739","SNARE","SNARE domain. Most if not all vesicular membrane fusion events in eukaryotic cells are believed to be mediated by a conserved fusion machinery, the SNARE [soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) receptors] machinery. The SNARE domain is thought to act as a protein-protein interaction module in the assembly of a SNARE protein complex.",".",".",".",".","."]
["ENSRNOG00000019931",182,15.31261889,595,38.27661072,0.400051588,-1.321742043,{"v":3.6863e-32,"d":"3.69E-32"},{"v":1.66705e-31,"d":"1.67E-31"},"down","yes","Map3k21","protein_coding","chr19:53880238-53913576:+","gi|672085451|ref|XP_008770896.1|",4117,0,"PREDICTED: LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase MLK4 isoform X2 [Rattus norvegicus]","gi|672085450|ref|XM_008772674.1|",5701,0,"PREDICTED: Rattus norvegicus similar to Mixed lineage kinase 4 (RGD1306091), transcript variant X2, mRNA","Q8VDG6",1424,0,"Mitogen-activated protein kinase kinase kinase 21",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0000165|MAPK cascade;GO:0006468|protein phosphorylation;",".","GO:0004672|protein kinase activity;GO:0004706|JUN kinase kinase kinase activity;GO:0004709|MAP kinase kinase kinase activity;GO:0005524|ATP binding;","K17534","MLK4, KIAA1804; mitogen-activated protein kinase kinase kinase MLK4 [EC:2.7.11.25]"]
["ENSRNOG00000018938",210,17.66840642,650,41.81478482,0.422539695,-1.242841216,{"v":6.15922e-32,"d":"6.16E-32"},{"v":2.76244E-31,"d":"2.76E-31"},"down","yes","Mkx","protein_coding","chr17:55077540-55156124:-","gi|148691080|gb|EDL23027.1|",1927,0,"mohawk, partial [Mus musculus]","gi|672030195|ref|XM_008774010.1|",3133,0,"PREDICTED: Rattus norvegicus mohawk homeobox (Mkx), transcript variant X2, mRNA","Q8BIA3",662,0,"Homeobox protein Mohawk",".",".",".",".","pfam05920","Homeobox_KN","Homeobox KN domain. This is a homeobox transcription factor KN domain conserved from fungi to human and plants.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0002932|tendon sheath development;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007517|muscle organ development;GO:0010468|regulation of gene expression;GO:0010628|positive regulation of gene expression;GO:0030199|collagen fibril organization;GO:0030279|negative regulation of ossification;GO:0032331|negative regulation of chondrocyte differentiation;GO:0032967|positive regulation of collagen biosynthetic process;GO:0035990|tendon cell differentiation;GO:0035992|tendon formation;GO:0036077|intratendonous ossification;GO:0045599|negative regulation of fat cell differentiation;GO:0045662|negative regulation of myoblast differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048468|cell development;GO:0071260|cellular response to mechanical stimulus;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;","K24890","MKX; homeobox protein Mohawk"]
["ENSRNOG00000014336",260,21.87516985,748,48.11916776,0.454604077,-1.137317472,{"v":6.35429e-32,"d":"6.35E-32"},{"v":2.84758e-31,"d":"2.85E-31"},"down","yes","Mcm5","protein_coding","chr19:13483066-13504389:+","gi|183986534|gb|AAI66442.1|",3713,0,"Mcm5 protein [Rattus norvegicus]","gi|672084082|ref|XM_008772283.1|",2921,0,"PREDICTED: Rattus norvegicus minichromosome maintenance complex component 5 (Mcm5), transcript variant X1, mRNA","P49718",1401,0,"DNA replication licensing factor MCM5","YLR274w",612,0,"COG1241","pfam00493","MCM","MCM2/3/5 family.","GO:0000727|double-strand break repair via break-induced replication;GO:0006270|DNA replication initiation;GO:0032508|DNA duplex unwinding;GO:0051301|cell division;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005694|chromosome;GO:0042555|MCM complex;","GO:0003688|DNA replication origin binding;GO:0003697|single-stranded DNA binding;GO:0005524|ATP binding;GO:0017116|single-stranded DNA-dependent ATP-dependent DNA helicase activity;GO:0043138|3'-5' DNA helicase activity;","K02209","MCM5, CDC46; DNA replication licensing factor MCM5 [EC:5.6.2.3]"]
["ENSRNOG00000028113",349,29.36320876,914,58.7980205,0.499391111,-1.001757954,{"v":9.91756e-32,"d":"9.92E-32"},{"v":4.41534e-31,"d":"4.42E-31"},"down","yes","Whamm","protein_coding","chr1:135526386-135554759:+","gi|195539466|ref|NP_001124200.1|",3743,0,"WASP homolog-associated protein with actin, membranes and microtubules [Rattus norvegicus]","gi|195539465|ref|NM_001130728.1|",2849,0,"Rattus norvegicus WAS protein homolog associated with actin, golgi membranes and microtubules (Whamm), mRNA","Q571B6",1227,0,"WASP homolog-associated protein with actin, membranes and microtubules",".",".",".",".","pfam12128","DUF3584","Protein of unknown function (DUF3584). This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.","GO:0006888|ER to Golgi vesicle-mediated transport;GO:0007015|actin filament organization;GO:0030032|lamellipodium assembly;GO:0034314|Arp2/3 complex-mediated actin nucleation;GO:0048041|focal adhesion assembly;GO:0051127|positive regulation of actin nucleation;GO:0090527|actin filament reorganization;GO:0097320|plasma membrane tubulation;","GO:0000139|Golgi membrane;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0033116|endoplasmic reticulum-Golgi intermediate compartment membrane;","GO:0003779|actin binding;GO:0008017|microtubule binding;GO:0031267|small GTPase binding;GO:0071933|Arp2/3 complex binding;","K20479","WHAMM; WASP homolog-associated protein with actin, membranes and microtubules"]
["ENSRNOG00000022937",124,10.43277331,469,30.17097551,0.345788399,-1.532038627,{"v":1.08857e-31,"d":"1.09E-31"},{"v":4.83055e-31,"d":"4.83E-31"},"down","yes","Bpifc","protein_coding","chr7:17861007-17905919:+","gi|157818469|ref|NP_001100243.1|",2684,0,"BPI fold-containing family C protein precursor [Rattus norvegicus]","gi|157818468|ref|NM_001106773.1|",2158,0,"Rattus norvegicus BPI fold containing family C (Bpifc), mRNA","Q8C186",945,0,"BPI fold-containing family C protein",".",".",".",".","pfam01273","LBP_BPI_CETP","LBP / BPI / CETP family, N-terminal domain. The N and C terminal domains of the LBP/BPI/CETP family are structurally similar.",".","GO:0005615|extracellular space;","GO:0008289|lipid binding;","K25377","BPIFC; BPI fold-containing family C"]
["ENSRNOG00000030109",228,19.18284125,683,43.93768928,0.436591946,-1.195642579,{"v":1.37077e-31,"d":"1.37E-31"},{"v":6.05814E-31,"d":"6.06E-31"},"down","yes","Kpna5","protein_coding","chr20:30822935-30888078:+","gi|564397925|ref|XP_006256504.1|",2775,0,"PREDICTED: importin subunit alpha-6 isoform X1 [Rattus norvegicus]","gi|672086178|ref|XR_362222.2|",4182,0,"PREDICTED: Rattus norvegicus karyopherin alpha 5 (importin alpha 6) (Kpna5), transcript variant X2, misc_RNA","Q56R16",1032,0,"Importin subunit alpha-6","SPCC962.03c",510,{"v":1e-164,"d":"1.00E-164"},"COG5064","pfam01749","IBB","Importin beta binding domain. This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.","GO:0006606|protein import into nucleus;GO:0006607|NLS-bearing protein import into nucleus;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0008139|nuclear localization sequence binding;GO:0061608|nuclear import signal receptor activity;","K15042","KPNA5_6; importin subunit alpha-6/7"]
["ENSRNOG00000014576",219,18.42562383,665,42.77974139,0.430709098,-1.215214296,{"v":1.47031e-31,"d":"1.47E-31"},{"v":6.48754e-31,"d":"6.49E-31"},"down","yes","Dock3","protein_coding","chr8:107552463-107903514:-","gi|564310604|ref|XP_006226619.1|",10369,0,"PREDICTED: dedicator of cytokinesis protein 3 isoform X1 [Rattus norvegicus]","gi|672063289|ref|XM_006243865.2|",8786,0,"PREDICTED: Rattus norvegicus dedicator of cyto-kinesis 3 (Dock3), transcript variant X1, mRNA","Q8CIQ7",3828,0,"Dedicator of cytokinesis protein 3",".",".",".",".","pfam06920","Ded_cyto","Dedicator of cytokinesis. This family represents a conserved region approximately 200 residues long within a number of eukaryotic dedicator of cytokinesis proteins. These are potential guanine nucleotide exchange factors, which activate some small GTPases by exchanging bound GDP for free GTP.","GO:0007264|small GTPase mediated signal transduction;GO:0050790|regulation of catalytic activity;","GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0005085|guanyl-nucleotide exchange factor activity;","K05727","DOCK3; dedicator of cytokinesis protein 3"]
["ENSRNOG00000001414",133,11.18999073,486,31.26459296,0.357912567,-1.482320893,{"v":2.68334e-31,"d":"2.68E-31"},{"v":1.17636E-30,"d":"1.18E-30"},"down","yes","Serpine1","protein_coding","chr12:19601272-19611657:+","gi|6981332|ref|NP_036752.1|",2140,0,"plasminogen activator inhibitor 1 precursor [Rattus norvegicus]","gi|6981331|ref|NM_012620.1|",2982,0,"Rattus norvegicus serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (Serpine1), mRNA","P20961",828,0,"Plasminogen activator inhibitor 1","all0778",168,{"v":4e-44,"d":"4.00E-44"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0000302|response to reactive oxygen species;GO:0001525|angiogenesis;GO:0001890|placenta development;GO:0008585|female gonad development;GO:0010469|regulation of signaling receptor activity;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010757|negative regulation of plasminogen activation;GO:0010951|negative regulation of endopeptidase activity;GO:0014912|negative regulation of smooth muscle cell migration;GO:0030194|positive regulation of blood coagulation;GO:0030336|negative regulation of cell migration;GO:0031667|response to nutrient levels;GO:0032496|response to lipopolysaccharide;GO:0032757|positive regulation of interleukin-8 production;GO:0032869|cellular response to insulin stimulus;GO:0032967|positive regulation of collagen biosynthetic process;GO:0033629|negative regulation of cell adhesion mediated by integrin;GO:0034097|response to cytokine;GO:0034616|response to laminar fluid shear stress;GO:0035491|positive regulation of leukotriene production involved in inflammatory response;GO:0035865|cellular response to potassium ion;GO:0036120|cellular response to platelet-derived growth factor stimulus;GO:0042127|regulation of cell proliferation;GO:0042246|tissue regeneration;GO:0042593|glucose homeostasis;GO:0042594|response to starvation;GO:0043627|response to estrogen;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0045576|mast cell activation;GO:0045765|regulation of angiogenesis;GO:0045766|positive regulation of angiogenesis;GO:0046697|decidualization;GO:0048146|positive regulation of fibroblast proliferation;GO:0048260|positive regulation of receptor-mediated endocytosis;GO:0050729|positive regulation of inflammatory response;GO:0050820|positive regulation of coagulation;GO:0050829|defense response to Gram-negative bacterium;GO:0051549|positive regulation of keratinocyte migration;GO:0051918|negative regulation of fibrinolysis;GO:0055093|response to hyperoxia;GO:0061044|negative regulation of vascular wound healing;GO:0070301|cellular response to hydrogen peroxide;GO:0070849|response to epidermal growth factor;GO:0071222|cellular response to lipopolysaccharide;GO:0071248|cellular response to metal ion;GO:0071258|cellular response to gravity;GO:0071260|cellular response to mechanical stimulus;GO:0071316|cellular response to nicotine;GO:0071318|cellular response to ATP;GO:0071320|cellular response to cAMP;GO:0071321|cellular response to cGMP;GO:0071333|cellular response to glucose stimulus;GO:0071347|cellular response to interleukin-1;GO:0071363|cellular response to growth factor stimulus;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0071377|cellular response to glucagon stimulus;GO:0071404|cellular response to low-density lipoprotein particle stimulus;GO:0071407|cellular response to organic cyclic compound;GO:0071409|cellular response to cycloheximide;GO:0071456|cellular response to hypoxia;GO:0071466|cellular response to xenobiotic stimulus;GO:0071549|cellular response to dexamethasone stimulus;GO:0071559|response to transforming growth factor beta;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0090026|positive regulation of monocyte chemotaxis;GO:0090280|positive regulation of calcium ion import;GO:0090399|replicative senescence;GO:0097187|dentinogenesis;GO:1901331|positive regulation of odontoblast differentiation;GO:1902042|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1904045|cellular response to aldosterone;GO:1904385|cellular response to angiotensin;GO:1904639|cellular response to resveratrol;GO:1905043|positive regulation of epithelium regeneration;GO:1990090|cellular response to nerve growth factor stimulus;GO:1990830|cellular response to leukemia inhibitory factor;GO:2000098|negative regulation of smooth muscle cell-matrix adhesion;GO:2000352|negative regulation of endothelial cell apoptotic process;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0042583|chromaffin granule;GO:0062023|collagen-containing extracellular matrix;GO:0070062|extracellular exosome;","GO:0002020|protease binding;GO:0004867|serine-type endopeptidase inhibitor activity;GO:0005102|signaling receptor binding;","K03982","SERPINE1, PAI1; plasminogen activator inhibitor 1"]
["ENSRNOG00000018651",321,27.00742124,857,55.13118552,0.489875575,-1.029512732,{"v":3.73646e-31,"d":"3.74E-31"},{"v":1.62886e-30,"d":"1.63E-30"},"down","yes","Agtpbp1","protein_coding","chr17:5120609-5238869:+","gi|157820001|ref|NP_001099570.1|",6257,0,"cytosolic carboxypeptidase 1 [Rattus norvegicus]","gi|672080868|ref|XM_008771435.1|",4485,0,"PREDICTED: Rattus norvegicus ATP/GTP binding protein 1 (Agtpbp1), transcript variant X1, mRNA","Q641K1",2321,0,"Cytosolic carboxypeptidase 1","NMA1274",101,{"v":1e-21,"d":"1.00E-21"},"COG2866","pfam00246","Peptidase_M14","Zinc carboxypeptidase.","GO:0001754|eye photoreceptor cell differentiation;GO:0006508|proteolysis;GO:0007005|mitochondrion organization;GO:0007628|adult walking behavior;GO:0008285|negative regulation of cell proliferation;GO:0021702|cerebellar Purkinje cell differentiation;GO:0021772|olfactory bulb development;GO:0021954|central nervous system neuron development;GO:0035608|protein deglutamylation;GO:0035609|C-terminal protein deglutamylation;GO:0035610|protein side chain deglutamylation;GO:0042133|neurotransmitter metabolic process;GO:0050905|neuromuscular process;GO:0060041|retina development in camera-type eye;GO:0098957|anterograde axonal transport of mitochondrion;GO:0098958|retrograde axonal transport of mitochondrion;GO:2000060|positive regulation of ubiquitin-dependent protein catabolic process;","GO:0005634|nucleus;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;GO:0043231|intracellular membrane-bounded organelle;GO:1904115|axon cytoplasm;","GO:0004181|metallocarboxypeptidase activity;GO:0008270|zinc ion binding;GO:0015631|tubulin binding;","K23435","AGTPBP1, CCP1; cytosolic carboxypeptidase protein 1 [EC:3.4.17.24]"]
["ENSRNOG00000020782",308,25.91366274,832,53.52292457,0.484160067,-1.046444003,{"v":4.53274e-31,"d":"4.53E-31"},{"v":1.97125e-30,"d":"1.97E-30"},"down","yes","Pspc1","protein_coding","chr15:30828626-30911202:-","gi|564386396|ref|XP_006252127.1|",1615,0,"PREDICTED: paraspeckle component 1 isoform X1 [Rattus norvegicus]","gi|672078279|ref|XR_359949.2|",2169,0,"PREDICTED: Rattus norvegicus paraspeckle component 1 (Pspc1), transcript variant X1, misc_RNA","Q4KLH4",618,0,"Paraspeckle component 1",".",".",".",".","pfam08075","NOPS","NOPS (NUC059) domain. This domain is found at the C-terminus of NONA and PSP1 proteins adjacent to 1 or 2 pfam00076 domains.","GO:0002218|activation of innate immune response;GO:0006355|regulation of transcription, DNA-templated;GO:0042752|regulation of circadian rhythm;GO:0045087|innate immune response;GO:0045892|negative regulation of transcription, DNA-templated;GO:0048511|rhythmic process;","GO:0001650|fibrillar center;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0016363|nuclear matrix;GO:0016607|nuclear speck;GO:0042382|paraspeckles;","GO:0003723|RNA binding;","K24993","PSPC1; paraspeckle component 1"]
["ENSRNOG00000016148",141,11.86307288,501,32.22954953,0.368080629,-1.441906266,{"v":5.61331e-31,"d":"5.61E-31"},{"v":2.43535e-30,"d":"2.44E-30"},"down","yes","Gtse1","protein_coding","chr7:116950053-116966806:+","gi|194473654|ref|NP_001123972.1|",3045,0,"G2 and S phase-expressed protein 1 [Rattus norvegicus]","gi|672059892|ref|XM_006242160.2|",2698,0,"PREDICTED: Rattus norvegicus G-2 and S-phase expressed 1 (Gtse1), transcript variant X1, mRNA","Q8R080",914,0,"G2 and S phase-expressed protein 1",".",".",".",".","pfam15259","GTSE1_N","G-2 and S-phase expressed 1. This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S phase-expressed-1) protein is specifically expressed during S and G2 phases of the cell cycle. It is mainly localized to the microtubules and when overexpressed delays the G2 to M transition. the full protein negatively regulates p53 transactivation function, protein levels, and p53-dependent apoptosis. This domain family is found in eukaryotes, and is approximately 140 amino acids in length. There is a conserved FDFD sequence motif.",".","GO:0005881|cytoplasmic microtubule;GO:0015630|microtubule cytoskeleton;","GO:0008017|microtubule binding;","K10129","GTSE1, B99; G-2 and S-phase expressed protein 1"]
["ENSRNOG00000003553",79,6.646686223,361,23.22328818,0.2862078,-1.804865104,{"v":7.593e-31,"d":"7.59E-31"},{"v":3.28638e-30,"d":"3.29E-30"},"down","yes","Efemp1","protein_coding","chr14:102610908-102690018:+","gi|58865654|ref|NP_001012039.1|",2554,0,"EGF-containing fibulin-like extracellular matrix protein 1 precursor [Rattus norvegicus]","gi|58865653|ref|NM_001012039.1|",2006,0,"Rattus norvegicus EGF-containing fibulin-like extracellular matrix protein 1 (Efemp1), mRNA","O35568",986,0,"EGF-containing fibulin-like extracellular matrix protein 1",".",".",".",".","pfam07645","EGF_CA","Calcium-binding EGF domain.","GO:0006355|regulation of transcription, DNA-templated;GO:0007173|epidermal growth factor receptor signaling pathway;GO:0008284|positive regulation of cell proliferation;GO:0010977|negative regulation of neuron projection development;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0031346|positive regulation of cell projection organization;GO:0032331|negative regulation of chondrocyte differentiation;GO:0043010|camera-type eye development;GO:0048048|embryonic eye morphogenesis;GO:0048050|post-embryonic eye morphogenesis;GO:1903975|regulation of glial cell migration;","GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0062023|collagen-containing extracellular matrix;","GO:0005006|epidermal growth factor-activated receptor activity;GO:0005154|epidermal growth factor receptor binding;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0008083|growth factor activity;","K18262","EFEMP1, FBLN3; EGF-containing fibulin-like extracellular matrix protein 1"]
["ENSRNOG00000023257",154,12.95683137,527,33.90214092,0.382183279,-1.387663436,{"v":9.16586e-31,"d":"9.17E-31"},{"v":3.94831e-30,"d":"3.95E-30"},"down","yes","Adamts9","protein_coding","chr4:125291490-125462929:-","gi|564347897|ref|XP_006236978.1|",8264,0,"PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X3 [Rattus norvegicus]","gi|672050431|ref|XM_008763126.1|",2154,0,"PREDICTED: Rattus norvegicus ADAM metallopeptidase with thrombospondin type 1 motif, 9 (Adamts9), transcript variant X2, mRNA","Q9P2N4",2703,0,"A disintegrin and metalloproteinase with thrombospondin motifs 9",".",".",".",".","pfam08685","GON","GON domain. The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) family of proteins. It contains several conserved cysteine residues.","GO:0003179|heart valve morphogenesis;GO:0003229|ventricular cardiac muscle tissue development;GO:0006508|proteolysis;GO:0007229|integrin-mediated signaling pathway;GO:0009617|response to bacterium;GO:0010596|negative regulation of endothelial cell migration;GO:0030198|extracellular matrix organization;GO:0035909|aorta morphogenesis;GO:0045636|positive regulation of melanocyte differentiation;GO:0048070|regulation of developmental pigmentation;GO:0090673|endothelial cell-matrix adhesion;GO:1903671|negative regulation of sprouting angiogenesis;","GO:0005615|extracellular space;GO:0005783|endoplasmic reticulum;GO:0009986|cell surface;GO:0031012|extracellular matrix;GO:0043231|intracellular membrane-bounded organelle;","GO:0004175|endopeptidase activity;GO:0004222|metalloendopeptidase activity;GO:0008237|metallopeptidase activity;GO:0008270|zinc ion binding;","K08624","ADAMTS9; a disintegrin and metalloproteinase with thrombospondin motifs 9 [EC:3.4.24.-]"]
["ENSRNOG00000019390",6,0.504811612,151,9.713896166,0.051967985,-4.266233064,{"v":1.00366E-30,"d":"1.00E-30"},{"v":4.31657e-30,"d":"4.32E-30"},"down","yes","Klhl40","protein_coding","chr8:121441287-121446800:+","gi|564366312|ref|XP_006244168.1|",3198,0,"PREDICTED: kelch-like protein 40 isoform X1 [Rattus norvegicus]","gi|672063610|ref|XM_006244106.2|",2331,0,"PREDICTED: Rattus norvegicus kelch-like family member 40 (Klhl40), transcript variant X1, mRNA","Q9D783",1222,0,"Kelch-like protein 40",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.","GO:0031397|negative regulation of protein ubiquitination;GO:0031398|positive regulation of protein ubiquitination;GO:0032435|negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032436|positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0048741|skeletal muscle fiber development;GO:0098528|skeletal muscle fiber differentiation;","GO:0005737|cytoplasm;GO:0031463|Cul3-RING ubiquitin ligase complex;GO:0031672|A band;GO:0031674|I band;",".","K10473","KBTBD5_10; kelch repeat and BTB domain-containing protein 5/10"]
["ENSRNOG00000047276",228,19.18284125,676,43.48737621,0.441112868,-1.180780247,{"v":1.06131E-30,"d":"1.06E-30"},{"v":4.5537e-30,"d":"4.55E-30"},"down","yes","ENSRNOG00000047276","protein_coding","chr16:70838568-70840795:+","gi|564364021|ref|XP_006243250.1|",2807,0,"PREDICTED: pyruvate kinase PKM isoform X2 [Rattus norvegicus]","gi|672086413|ref|XM_008772937.1|",1573,0,"PREDICTED: Rattus norvegicus M2 pyruvate kinase-like (LOC100362738), mRNA","P14618",1009,0,"Pyruvate kinase PKM","SPAC4H3.10c",486,{"v":3e-163,"d":"3.00E-163"},"COG0469","pfam00224","PK","Pyruvate kinase, barrel domain. This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.","GO:0006096|glycolytic process;",".","GO:0000287|magnesium ion binding;GO:0005524|ATP binding;GO:0016301|kinase activity;GO:0030955|potassium ion binding;",".","."]
["ENSRNOG00000011253",80,6.730821492,361,23.22328818,0.289830684,-1.786717757,{"v":1.92182e-30,"d":"1.92E-30"},{"v":8.17835e-30,"d":"8.18E-30"},"down","yes","Trmt9b","protein_coding","chr16:55743018-55792144:-","gi|157823389|ref|NP_001100784.1|",2414,0,"putative methyltransferase KIAA1456 homolog [Rattus norvegicus]","gi|157823388|ref|NM_001107314.1|",2491,0,"Rattus norvegicus similar to 6430573F11Rik protein (RGD1304810), mRNA","Q80WQ4",814,0,"Probable tRNA methyltransferase 9B","SPAC13D6.03c",147,{"v":9e-39,"d":"9.00E-39"},"COG0500","pfam08241","Methyltransf_11","Methyltransferase domain. Members of this family are SAM dependent methyltransferases.","GO:0002098|tRNA wobble uridine modification;GO:0030488|tRNA methylation;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0000049|tRNA binding;GO:0008175|tRNA methyltransferase activity;GO:0016300|tRNA (uracil) methyltransferase activity;",".","."]
["ENSRNOG00000020125",227,19.09870598,672,43.23005446,0.441792318,-1.178559761,{"v":1.9226E-30,"d":"1.92E-30"},{"v":8.17835e-30,"d":"8.18E-30"},"down","yes","Cd79a","protein_coding","chr1:80493581-80497935:+","gi|392337482|ref|XP_003753271.1|",965,{"v":5e-128,"d":"5.00E-128"},"PREDICTED: B-cell antigen receptor complex-associated protein alpha chain isoform X1 [Rattus norvegicus]","gi|298904658|emb|FQ225076.1|",996,0,"Rattus norvegicus TL0AEA55YD17 mRNA sequence","P11911",339,{"v":5e-115,"d":"5.00E-115"},"B-cell antigen receptor complex-associated protein alpha chain",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0002250|adaptive immune response;GO:0030183|B cell differentiation;GO:0042100|B cell proliferation;GO:0042113|B cell activation;GO:0050853|B cell receptor signaling pathway;","GO:0005771|multivesicular body;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0019815|B cell receptor complex;GO:0045121|membrane raft;","GO:0004888|transmembrane signaling receptor activity;GO:0042802|identical protein binding;","K06506","CD79A, IGA; CD79A antigen"]
["ENSRNOG00000022267",40,3.365410746,259,16.66158349,0.201986249,-2.307671018,{"v":2.03801e-30,"d":"2.04E-30"},{"v":8.66249e-30,"d":"8.66E-30"},"down","yes","AABR07039334.1","protein_coding","chrX:68023294-68024825:+","gi|564322934|ref|XP_006227465.1|",1029,{"v":1E-139,"d":"1.00E-139"},"PREDICTED: polyadenylate-binding protein 1-like 2 [Rattus norvegicus]","gi|672032477|ref|XM_006227403.2|",612,0,"PREDICTED: Rattus norvegicus poly(A) binding protein, cytoplasmic 1-like 2A (Pabpc1l2a), mRNA","Q5JQF8",379,{"v":3e-133,"d":"3.00E-133"},"Polyadenylate-binding protein 1-like 2",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.",".",".",".","K13126","PABPC; polyadenylate-binding protein"]
["ENSRNOG00000067971",14,1.177893761,179,11.51514844,0.102290801,-3.28925168,{"v":2.14785E-30,"d":"2.15E-30"},{"v":9.12106e-30,"d":"9.12E-30"},"down","yes","Sprn","protein_coding","chr1:194943826-194948460:-","gi|149061483|gb|EDM11906.1|",482,{"v":9e-53,"d":"9.00E-53"},"rCG47900, isoform CRA_c [Rattus norvegicus]","gi|672038941|ref|XM_006230573.2|",2992,0,"PREDICTED: Rattus norvegicus shadow of prion protein homolog (zebrafish) (Sprn), transcript variant X1, mRNA","Q5BIV7",103,{"v":2e-23,"d":"2.00E-23"},"Shadow of prion protein",".",".",".",".","pfam14999","Shadoo","Shadow of prion protein, neuroprotective. This protein family is a Prion-like protein and its function is neuroprotective and similar to PrP(C)-like. Shadoo is mainly expressed in the brain, and highly expressed in the hippocampus, the area of the brain which co-ordinates memory as well as spatial memory and navigation. This protein may also alter the biological actions of normal and abnormal Prion Protein (PrP) which lead to lethal neurodegenerative diseases. This family of proteins is found in eukaryotes. Proteins in this family are approximately 150 amino acids in length, of which the first 90 are alanine rich.",".",".",".",".","."]
["ENSRNOG00000047218",316,26.58674489,841,54.10189851,0.491419814,-1.024972067,{"v":2.14925e-30,"d":"2.15E-30"},{"v":9.12106e-30,"d":"9.12E-30"},"down","yes","Clic5","protein_coding","chr9:16710980-16813427:-","gi|16758390|ref|NP_446055.1|",1338,{"v":6e-167,"d":"6.00E-167"},"chloride intracellular channel protein 5 [Rattus norvegicus]","gi|158186627|ref|NM_053603.2|",5839,0,"Rattus norvegicus chloride intracellular channel 5 (Clic5), nuclear gene encoding mitochondrial protein, mRNA","Q9EPT8",520,{"v":2e-168,"d":"2.00E-168"},"Chloride intracellular channel protein 5",".",".",".",".","pfam13409","GST_N_2","Glutathione S-transferase, N-terminal domain. This family is closely related to pfam02798.","GO:0002021|response to dietary excess;GO:0002024|diet induced thermogenesis;GO:0006749|glutathione metabolic process;GO:0006821|chloride transport;GO:0007601|visual perception;GO:0007605|sensory perception of sound;GO:0008104|protein localization;GO:0034220|ion transmembrane transport;GO:0034765|regulation of ion transmembrane transport;GO:0050885|neuromuscular process controlling balance;GO:0060088|auditory receptor cell stereocilium organization;","GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005815|microtubule organizing center;GO:0005938|cell cortex;GO:0015629|actin cytoskeleton;GO:0016020|membrane;GO:0016324|apical plasma membrane;GO:0032420|stereocilium;GO:0032421|stereocilium bundle;GO:0034707|chloride channel complex;","GO:0005244|voltage-gated ion channel activity;GO:0005254|chloride channel activity;","K05025","CLIC5; chloride intracellular channel protein 5"]
["ENSRNOG00000037449",127,10.68517912,462,29.72066244,0.359520221,-1.47585518,{"v":1.18617E-29,"d":"1.19E-29"},{"v":4.93771e-29,"d":"4.94E-29"},"down","yes","Pole","protein_coding","chr12:46345420-46393939:-","gi|312922377|ref|NP_001100622.2|",12000,0,"DNA polymerase epsilon catalytic subunit A [Rattus norvegicus]","gi|312922376|ref|NM_001107152.2|",7101,0,"Rattus norvegicus polymerase (DNA directed), epsilon, catalytic subunit (Pole), mRNA","Q9WVF7",4556,0,"DNA polymerase epsilon catalytic subunit A","SPBC25H2.13c",1760,0,"COG0417","pfam08490","DUF1744","Domain of unknown function (DUF1744). This domain is found on the epsilon catalytic subunit of DNA polymerase. It is found C terminal to pfam03104 and pfam00136.","GO:0000082|G1/S transition of mitotic cell cycle;GO:0000278|mitotic cell cycle;GO:0000731|DNA synthesis involved in DNA repair;GO:0006260|DNA replication;GO:0006272|leading strand elongation;GO:0006287|base-excision repair, gap-filling;GO:0006297|nucleotide-excision repair, DNA gap filling;GO:0045004|DNA replication proofreading;GO:0048568|embryonic organ development;GO:0071897|DNA biosynthetic process;GO:0090305|nucleic acid phosphodiester bond hydrolysis;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0008622|epsilon DNA polymerase complex;","GO:0000166|nucleotide binding;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003887|DNA-directed DNA polymerase activity;GO:0008270|zinc ion binding;GO:0008310|single-stranded DNA 3'-5' exodeoxyribonuclease activity;GO:0051539|4 iron, 4 sulfur cluster binding;","K02324","POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]"]
["ENSRNOG00000008088",214,18.00494749,639,41.10715,0.438000384,-1.19099596,{"v":1.72425e-29,"d":"1.72E-29"},{"v":7.15024e-29,"d":"7.15E-29"},"down","yes","Btbd3","protein_coding","chr3:125591490-125619038:+","gi|26006233|dbj|BAC41459.1|",2632,0,"mKIAA0952 protein [Mus musculus]","gi|157821298|ref|NM_001107782.1|",2398,0,"Rattus norvegicus BTB domain containing 3 (Btbd3), mRNA","P58545",990,0,"BTB/POZ domain-containing protein 3",".",".",".",".","pfam08005","PHR","PHR domain. This domain is called PHR as it was original found in the proteins PAM, highwire and RPM. This domain can be duplicated in the highwire, PFAM and PRM sequence.  The C-terminal region of the protein BTBD1 includes the PHR domain and is known to interact with Topoisomerase I, an enzyme which relaxes DNA supercoils.","GO:0021987|cerebral cortex development;GO:0022008|neurogenesis;GO:0048813|dendrite morphogenesis;","GO:0005634|nucleus;GO:0005829|cytosol;","GO:0042802|identical protein binding;","K10478","BTBD3_6; BTB/POZ domain-containing protein 3/6"]
["ENSRNOG00000032973",80,6.730821492,355,22.83730556,0.29472923,-1.762537945,{"v":1.95384e-29,"d":"1.95E-29"},{"v":8.09615e-29,"d":"8.10E-29"},"down","yes","Il13ra2","protein_coding","chrX:111002592-111072381:-","gi|81916005|sp|Q8VHK6.1|I13R2_RAT",1844,0,"RecName: Full=Interleukin-13 receptor subunit alpha-2; Short=IL-13 receptor subunit alpha-2; Short=IL-13R subunit alpha-2; Short=IL-13R-alpha-2; Short=IL-13RA2; AltName: CD_antigen=CD213a2; Flags: Precursor","gi|451770415|ref|NM_133538.2|",1872,0,"Rattus norvegicus interleukin 13 receptor subunit alpha 2 (Il13ra2), mRNA","Q8VHK6",714,0,"Interleukin-13 receptor subunit alpha-2",".",".",".",".","pfam09240","IL6Ra-bind","Interleukin-6 receptor alpha chain, binding. Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.","GO:0002638|negative regulation of immunoglobulin production;GO:0016064|immunoglobulin mediated immune response;GO:0019221|cytokine-mediated signaling pathway;GO:0043305|negative regulation of mast cell degranulation;GO:0071260|cellular response to mechanical stimulus;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0043235|receptor complex;","GO:0004896|cytokine receptor activity;GO:0019955|cytokine binding;","K05077","IL13RA2, CD213A2; interleukin 13 receptor alpha-2"]
["ENSRNOG00000008837",100,8.413526865,401,25.79650571,0.326149865,-1.616393062,{"v":2.03274e-29,"d":"2.03E-29"},{"v":8.41029e-29,"d":"8.41E-29"},"down","yes","Ass1","protein_coding","chr3:14747368-14796903:+","gi|795329564|ref|XP_011826543.1|",2173,0,"PREDICTED: argininosuccinate synthase isoform X2 [Mandrillus leucophaeus]","gi|672044859|ref|XM_006233911.2|",1651,0,"PREDICTED: Rattus norvegicus argininosuccinate synthase 1 (Ass1), transcript variant X1, mRNA","P09034",834,0,"Argininosuccinate synthase","TM1780",479,{"v":2e-164,"d":"2.00E-164"},"COG0137","pfam00764","Arginosuc_synth","Arginosuccinate synthase. This family contains a PP-loop motif.","GO:0000050|urea cycle;GO:0000052|citrulline metabolic process;GO:0000053|argininosuccinate metabolic process;GO:0001822|kidney development;GO:0001889|liver development;GO:0006526|arginine biosynthetic process;GO:0006531|aspartate metabolic process;GO:0006953|acute-phase response;GO:0007494|midgut development;GO:0007568|aging;GO:0007584|response to nutrient;GO:0007623|circadian rhythm;GO:0009410|response to xenobiotic stimulus;GO:0009636|response to toxic substance;GO:0010043|response to zinc ion;GO:0010046|response to mycotoxin;GO:0014075|response to amine;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0043200|response to amino acid;GO:0043434|response to peptide hormone;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0048545|response to steroid hormone;GO:0051384|response to glucocorticoid;GO:0060416|response to growth hormone;GO:0060539|diaphragm development;GO:0070542|response to fatty acid;GO:0071222|cellular response to lipopolysaccharide;GO:0071230|cellular response to amino acid stimulus;GO:0071242|cellular response to ammonium ion;GO:0071320|cellular response to cAMP;GO:0071346|cellular response to interferon-gamma;GO:0071356|cellular response to tumor necrosis factor;GO:0071377|cellular response to glucagon stimulus;GO:0071400|cellular response to oleic acid;GO:0071418|cellular response to amine stimulus;GO:0071499|cellular response to laminar fluid shear stress;GO:0071549|cellular response to dexamethasone stimulus;GO:1903038|negative regulation of leukocyte cell-cell adhesion;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0005764|lysosome;GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0070852|cell body fiber;","GO:0004055|argininosuccinate synthase activity;GO:0005524|ATP binding;GO:0015643|toxic substance binding;GO:0016597|amino acid binding;GO:0042802|identical protein binding;","K01940","argG, ASS1; argininosuccinate synthase [EC:6.3.4.5]"]
["ENSRNOG00000020812",285,23.97855156,774,49.79175916,0.48157671,-1.054162472,{"v":2.37175E-29,"d":"2.37E-29"},{"v":9.75363e-29,"d":"9.75E-29"},"down","yes","Gys1","protein_coding","chr1:95915443-95935292:+","gi|157823922|ref|NP_001103085.1|",3429,0,"glycogen [starch] synthase, muscle [Rattus norvegicus]","gi|157823921|ref|NM_001109615.1|",3691,0,"Rattus norvegicus glycogen synthase 1 (Gys1), mRNA","A2RRU1",1325,0,"Glycogen [starch] synthase, muscle","YFR015c",709,0,"COG0438","pfam05693","Glycogen_syn","Glycogen synthase. This family consists of the eukaryotic glycogen synthase proteins GYS1, GYS2 and GYS3. Glycogen synthase (GS) is the enzyme responsible for the synthesis of -1,4-linked glucose chains in glycogen. It is the rate limiting enzyme in the synthesis of the polysaccharide, and its activity is highly regulated through phosphorylation at multiple sites and also by allosteric effectors, mainly glucose 6-phosphate (G6P).","GO:0005977|glycogen metabolic process;GO:0005978|glycogen biosynthetic process;GO:0007507|heart development;","GO:0005737|cytoplasm;GO:0016234|inclusion body;","GO:0004373|glycogen (starch) synthase activity;GO:0005536|glucose binding;GO:0019901|protein kinase binding;GO:0061547|glycogen synthase activity, transferring glucose-1-phosphate;","K00693","GYS; glycogen synthase [EC:2.4.1.11]"]
["ENSRNOG00000013064",233,19.60351759,674,43.35871534,0.452124041,-1.145209462,{"v":3.10207e-29,"d":"3.10E-29"},{"v":1.2709E-28,"d":"1.27E-28"},"down","yes","Lrp8","protein_coding","chr5:122563453-122631352:+","gi|564352131|ref|XP_006238633.1|",4510,0,"PREDICTED: low-density lipoprotein receptor-related protein 8 isoform X8 [Rattus norvegicus]","gi|672053436|ref|XM_006238571.2|",3487,0,"PREDICTED: Rattus norvegicus low density lipoprotein receptor-related protein 8, apolipoprotein e receptor (Lrp8), transcript variant X8, mRNA","Q924X6",1686,0,"Low-density lipoprotein receptor-related protein 8",".",".",".",".","pfam00058","Ldl_recept_b","Low-density lipoprotein receptor repeat class B. This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.","GO:0006897|endocytosis;GO:0007268|chemical synaptic transmission;GO:0009410|response to xenobiotic stimulus;GO:0021517|ventral spinal cord development;GO:0021541|ammon gyrus development;GO:0021766|hippocampus development;GO:0021819|layer formation in cerebral cortex;GO:0021987|cerebral cortex development;GO:0032793|positive regulation of CREB transcription factor activity;GO:0038026|reelin-mediated signaling pathway;GO:0042981|regulation of apoptotic process;GO:0045088|regulation of innate immune response;GO:0045860|positive regulation of protein kinase activity;GO:0048813|dendrite morphogenesis;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050804|modulation of chemical synaptic transmission;GO:0061003|positive regulation of dendritic spine morphogenesis;GO:0061098|positive regulation of protein tyrosine kinase activity;GO:0071363|cellular response to growth factor stimulus;GO:0071397|cellular response to cholesterol;GO:1900006|positive regulation of dendrite development;","GO:0005615|extracellular space;GO:0005875|microtubule associated complex;GO:0005886|plasma membrane;GO:0005901|caveola;GO:0009986|cell surface;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0043025|neuronal cell body;GO:0043235|receptor complex;","GO:0001540|amyloid-beta binding;GO:0005509|calcium ion binding;GO:0008035|high-density lipoprotein particle binding;GO:0019894|kinesin binding;GO:0030229|very-low-density lipoprotein particle receptor activity;GO:0034185|apolipoprotein binding;GO:0038025|reelin receptor activity;GO:0047485|protein N-terminus binding;GO:0048306|calcium-dependent protein binding;","K20052","LRP8, APOER2; low-density lipoprotein receptor-related protein 8"]
["ENSRNOG00000061085",140,11.77893761,486,31.26459296,0.376750071,-1.408320312,{"v":4.15091E-29,"d":"4.15E-29"},{"v":1.6955e-28,"d":"1.70E-28"},"down","yes","Fancd2","protein_coding","chr4:146679179-146743412:+","gi|48843737|ref|NP_001001719.1|",7422,0,"Fanconi anemia group D2 protein homolog [Rattus norvegicus]","gi|48843736|ref|NM_001001719.1|",4365,0,"Rattus norvegicus Fanconi anemia, complementation group D2 (Fancd2), mRNA","Q6IV68",2831,0,"Fanconi anemia group D2 protein homolog",".",".",".",".","pfam14631","FancD2","Fanconi anaemia protein FancD2 nuclease. The Fanconi anaemia protein FancD2 is a nuclease necessary for the repair of DNA interstrand-crosslinks.","GO:0006281|DNA repair;GO:0006974|cellular response to DNA damage stimulus;GO:0007129|synapsis;GO:0007276|gamete generation;GO:0008150|biological_process;GO:0010332|response to gamma radiation;GO:0031573|intra-S DNA damage checkpoint;GO:0034599|cellular response to oxidative stress;GO:0036297|interstrand cross-link repair;GO:0045589|regulation of regulatory T cell differentiation;GO:0048854|brain morphogenesis;GO:0050727|regulation of inflammatory response;GO:0051090|regulation of DNA-binding transcription factor activity;GO:0097150|neuronal stem cell population maintenance;GO:1990918|double-strand break repair involved in meiotic recombination;GO:2000348|regulation of CD40 signaling pathway;","GO:0000793|condensed chromosome;GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005829|cytosol;GO:0016604|nuclear body;","GO:0003674|molecular_function;GO:0070182|DNA polymerase binding;","K10891","FANCD2; fanconi anemia group D2 protein"]
["ENSRNOG00000007886",16,1.346164298,180,11.57947887,0.116254308,-3.104643922,{"v":4.19451e-29,"d":"4.19E-29"},{"v":1.71203e-28,"d":"1.71E-28"},"down","yes","Orm1","protein_coding","chr5:76772941-76776154:+","gi|16757980|ref|NP_445740.1|",528,{"v":2e-62,"d":"2.00E-62"},"alpha-1-acid glycoprotein precursor [Rattus norvegicus]","gi|298906865|emb|FQ228584.1|",478,0,"Rattus norvegicus TL0ADA6YH24 mRNA sequence","P02764",207,{"v":5e-64,"d":"5.00E-64"},"Alpha-1-acid glycoprotein",".",".",".",".","pfam00061","Lipocalin","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.","GO:0002438|acute inflammatory response to antigenic stimulus;GO:0002439|chronic inflammatory response to antigenic stimulus;GO:0002682|regulation of immune system process;GO:0006953|acute-phase response;GO:0009410|response to xenobiotic stimulus;GO:0014070|response to organic cyclic compound;GO:0031100|animal organ regeneration;GO:0032496|response to lipopolysaccharide;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032732|positive regulation of interleukin-1 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0033197|response to vitamin E;GO:0071300|cellular response to retinoic acid;GO:0071378|cellular response to growth hormone stimulus;GO:0071385|cellular response to glucocorticoid stimulus;","GO:0005615|extracellular space;","GO:0036094|small molecule binding;","K17308","ORM, AGP; alpha-1-acid glycoprotein"]
["ENSRNOG00000018752",137,11.5265318,479,30.81427989,0.374064617,-1.418640588,{"v":5.17074e-29,"d":"5.17E-29"},{"v":2.10261e-28,"d":"2.10E-28"},"down","yes","ENSRNOG00000018752","protein_coding","chr1:201507859-201517605:+","gi|533139327|ref|XP_005384395.1|",1468,0,"PREDICTED: cardiotrophin-like cytokine factor 1 isoform X1 [Chinchilla lanigera]","gi|76563943|ref|NM_207615.2|",1602,0,"Rattus norvegicus cardiotrophin-like cytokine factor 1 (Clcf1), mRNA","Q9QZM3",464,{"v":1e-158,"d":"1.00E-158"},"Cardiotrophin-like cytokine factor 1",".",".",".",".","pfam06875","PRF","Plethodontid receptivity factor PRF. This family consists of several plethodontid receptivity factor (PRF) proteins which seem to be specific to Plethodon jordani (Jordan's salamander). PRF is a courtship pheromone produced by males increase female receptivity.","GO:0002639|positive regulation of immunoglobulin production;GO:0007166|cell surface receptor signaling pathway;GO:0007259|JAK-STAT cascade;GO:0008284|positive regulation of cell proliferation;GO:0030183|B cell differentiation;GO:0030890|positive regulation of B cell proliferation;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0043524|negative regulation of neuron apoptotic process;GO:0048295|positive regulation of isotype switching to IgE isotypes;GO:0048711|positive regulation of astrocyte differentiation;","GO:0005576|extracellular region;GO:0097058|CRLF-CLCF1 complex;GO:0097059|CNTFR-CLCF1 complex;","GO:0005102|signaling receptor binding;GO:0005125|cytokine activity;GO:0005127|ciliary neurotrophic factor receptor binding;","K05421","CLCF1, BSF3, CLC; cardiotrophin-like cytokine factor 1"]
["ENSRNOG00000065844",69,5.805333537,326,20.97172285,0.276817197,-1.852994523,{"v":5.55498e-29,"d":"5.55E-29"},{"v":2.2538e-28,"d":"2.25E-28"},"down","yes","ENSRNOG00000065844","protein_coding","chr10:105518792-105520817:-","gi|26330153|dbj|BAC28815.1|",215,{"v":3e-17,"d":"3.00E-17"},"unnamed protein product [Mus musculus]","gi|74188009|dbj|AK162948.1|",951,0,"Mus musculus adult male spinal cord cDNA, RIKEN full-length enriched library, clone:A330069N23 product:hypothetical protein, full insert sequence",".",".",".",".",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.",".",".",".",".","."]
["ENSRNOG00000009322",316,26.58674489,828,53.26560282,0.499135342,-1.002497035,{"v":6.18753e-29,"d":"6.19E-29"},{"v":2.50298E-28,"d":"2.50E-28"},"down","yes","Ccdc126","protein_coding","chr4:78297551-78318655:+","gi|157823203|ref|NP_001102702.1|",572,{"v":8e-66,"d":"8.00E-66"},"coiled-coil domain-containing protein 126 [Rattus norvegicus]","gi|197927369|ref|NM_001109232.2|",2266,0,"Rattus norvegicus coiled-coil domain containing 126 (Ccdc126), mRNA","Q8BIS8",220,{"v":1e-65,"d":"1.00E-65"},"Coiled-coil domain-containing protein 126",".",".",".",".","pfam15027","DUF4525","Domain of unknown function (DUF4525). This domain is found in eukaryotes. It is often found at the N-terminus of glycosyltransferase family 18 enzymes (pfam15024). It is also found in coiled-coil domain-containing protein 126.",".","GO:0005576|extracellular region;",".",".","."]
["ENSRNOG00000001701",74,6.22600988,335,21.55069679,0.28890063,-1.791354745,{"v":1.82238e-28,"d":"1.82E-28"},{"v":7.25334e-28,"d":"7.25E-28"},"down","yes","Cbr3","protein_coding","chr11:33008615-33016875:+","gi|157819653|ref|NP_001100580.1|",1471,0,"carbonyl reductase [NADPH] 3 [Rattus norvegicus]","gi|157819652|ref|NM_001107110.1|",1175,0,"Rattus norvegicus carbonyl reductase 3 (Cbr3), mRNA","Q8K354",560,0,"Carbonyl reductase [NADPH] 3","all0352",145,{"v":2e-39,"d":"2.00E-39"},"COG1028","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.","GO:0042376|phylloquinone catabolic process;GO:0050890|cognition;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0000253|3-keto sterol reductase activity;GO:0004090|carbonyl reductase (NADPH) activity;GO:0016491|oxidoreductase activity;GO:0070402|NADPH binding;","K00084","CBR3; carbonyl reductase 3 [EC:1.1.1.184]"]
["ENSRNOG00000057470",191,16.06983631,581,37.37598459,0.429950849,-1.217756351,{"v":7.19525e-28,"d":"7.20E-28"},{"v":2.80437e-27,"d":"2.80E-27"},"down","yes","Pla2g12a","protein_coding","chr2:218436513-218452740:+","gi|672044253|ref|XP_008759737.1|",819,{"v":6e-104,"d":"6.00E-104"},"PREDICTED: group XIIA secretory phospholipase A2 isoform X1 [Rattus norvegicus]","gi|672044252|ref|XM_008761515.1|",1501,0,"PREDICTED: Rattus norvegicus phospholipase A2, group XIIA (Pla2g12a), transcript variant X1, mRNA","Q9EPR2",314,{"v":2e-103,"d":"2.00E-103"},"Group XIIA secretory phospholipase A2",".",".",".",".","pfam06951","PLA2G12","Group XII secretory phospholipase A2 precursor (PLA2G12). This family consists of several group XII secretory phospholipase A2 precursor (PLA2G12) (EC:3.1.1.4) proteins. Group XII and group V PLA(2)s are thought to participate in helper T cell immune response through release of immediate second signals and generation of downstream eicosanoids.","GO:0006644|phospholipid metabolic process;GO:0016042|lipid catabolic process;GO:0050482|arachidonic acid secretion;","GO:0005576|extracellular region;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;","GO:0004623|phospholipase A2 activity;GO:0005509|calcium ion binding;","K01047","PLA2G, SPLA2; secretory phospholipase A2 [EC:3.1.1.4]"]
["ENSRNOG00000036897",22,1.85097591,193,12.41577457,0.149082596,-2.745816244,{"v":1.00368E-27,"d":"1.00E-27"},{"v":3.89236E-27,"d":"3.89E-27"},"down","yes","Defb24","protein_coding","chr3:141046564-141052753:-","gi|82775357|ref|NP_001032597.1|",296,{"v":5e-32,"d":"5.00E-32"},"beta-defensin 119 precursor [Rattus norvegicus]","gi|82775356|ref|NM_001037508.1|",240,{"v":4e-121,"d":"4.00E-121"},"Rattus norvegicus defensin beta 24 (Defb24), mRNA","Q8K3I8",107,{"v":3e-29,"d":"3.00E-29"},"Beta-defensin 19",".",".",".",".","pfam13841","Defensin_beta_2","Beta defensin. The beta defensins are antimicrobial peptides implicated in the resistance of epithelial surfaces to microbial colonisation.","GO:0045087|innate immune response;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:0061760|antifungal innate immune response;",".","GO:0001530|lipopolysaccharide binding;","K25606","DEFB; defensin, beta"]
["ENSRNOG00000004330",90,7.572174178,367,23.60927081,0.320728846,-1.640573982,{"v":1.30141e-27,"d":"1.30E-27"},{"v":5.0255e-27,"d":"5.03E-27"},"down","yes","Chrdl1","protein_coding","chrX:106889125-106992921:-","gi|41054820|ref|NP_955796.1|",2791,0,"chordin-like protein 1 [Rattus norvegicus]","gi|672088215|ref|XM_006257373.2|",4098,0,"PREDICTED: Rattus norvegicus chordin-like 1 (Chrdl1), transcript variant X1, mRNA","Q76LD0",929,0,"Chordin-like protein 1",".",".",".",".","pfam00093","VWC","von Willebrand factor type C domain. The high cutoff was used to prevent overlap with pfam00094.","GO:0001503|ossification;GO:0001654|eye development;GO:0001709|cell fate determination;GO:0030182|neuron differentiation;GO:0030514|negative regulation of BMP signaling pathway;","GO:0005576|extracellular region;",".","K24520","CHRDL1; chordin-like protein 1"]
["ENSRNOG00000006116",146,12.28374922,488,31.39325383,0.391286271,-1.353703604,{"v":1.30314E-27,"d":"1.30E-27"},{"v":5.02865e-27,"d":"5.03E-27"},"down","yes","Hk2","protein_coding","chr4:115234509-115283530:-","gi|7549765|ref|NP_036867.1|",4892,0,"hexokinase-2 [Rattus norvegicus]","gi|402692979|ref|NM_012735.2|",3630,0,"Rattus norvegicus hexokinase 2 (Hk2), mRNA","P27881",1889,0,"Hexokinase-2","SPAC24H6.04",282,{"v":1e-82,"d":"1.00E-82"},"COG5026","pfam03727","Hexokinase_2","Hexokinase. Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam00349. Some members of the family have two copies of each of these domains.","GO:0001666|response to hypoxia;GO:0001678|cellular glucose homeostasis;GO:0002931|response to ischemia;GO:0006002|fructose 6-phosphate metabolic process;GO:0006006|glucose metabolic process;GO:0006007|glucose catabolic process;GO:0006096|glycolytic process;GO:0007595|lactation;GO:0008637|apoptotic mitochondrial changes;GO:0035795|negative regulation of mitochondrial membrane permeability;GO:0045766|positive regulation of angiogenesis;GO:0046324|regulation of glucose import;GO:0046835|carbohydrate phosphorylation;GO:0051156|glucose 6-phosphate metabolic process;GO:0072655|establishment of protein localization to mitochondrion;GO:0072656|maintenance of protein location in mitochondrion;GO:1904925|positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization;GO:1990830|cellular response to leukemia inhibitory factor;GO:2000378|negative regulation of reactive oxygen species metabolic process;","GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0005813|centrosome;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016529|sarcoplasmic reticulum;GO:0043231|intracellular membrane-bounded organelle;","GO:0004340|glucokinase activity;GO:0004396|hexokinase activity;GO:0005524|ATP binding;GO:0005536|glucose binding;GO:0008865|fructokinase activity;GO:0019158|mannokinase activity;","K00844","HK; hexokinase [EC:2.7.1.1]"]
["ENSRNOG00000067962",23,1.935111179,195,12.54443545,0.154260523,-2.696559183,{"v":1.70069e-27,"d":"1.70E-27"},{"v":6.53956e-27,"d":"6.54E-27"},"down","yes","Nat8f3","protein_coding","chr4:118239304-118285500:-","gi|564303970|ref|XP_006225036.1|",913,{"v":1E-108,"d":"1.00E-108"},"PREDICTED: probable N-acetyltransferase CML3 [Rattus norvegicus]","gi|672050325|ref|XM_006236798.2|",3391,0,"PREDICTED: Rattus norvegicus camello-like 3 (Cml3), mRNA","Q9QXS4",356,{"v":3e-110,"d":"3.00E-110"},"N-acetyltransferase family 8 member 3",".",".",".",".","pfam00583","Acetyltransf_1","Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.",".",".",".",".","."]
["ENSRNOG00000008766",24,2.019246448,198,12.73742676,0.158528601,-2.657184945,{"v":1.75256e-27,"d":"1.75E-27"},{"v":6.73425e-27,"d":"6.73E-27"},"down","yes","Grin2b","protein_coding","chr4:168599546-169042279:-","gi|149049163|gb|EDM01617.1|",7896,0,"glutamate receptor, ionotropic, N-methyl D-aspartate 2B, isoform CRA_a [Rattus norvegicus]","gi|6980983|ref|NM_012574.1|",5253,0,"Rattus norvegicus glutamate ionotropic receptor NMDA type subunit 2B (Grin2b), mRNA","Q00960",3041,0,"Glutamate receptor ionotropic, NMDA 2B",".",".",".",".","pfam10565","NMDAR2_C","N-methyl D-aspartate receptor 2B3 C-terminus. This domain is found at the C-terminus of many NMDA-receptor proteins, many of which also carry the Ligated ion-channel family pfam00060 further upstream as well as the ANF_receptor family pfam01094. This region is predicted to be a large extra-cellular domain of the NMDA receptor proteins, being highly hydrophilic, and is thought to be integrally involved in the function of the receptor. The region also carries a number of potential N-glycosylation sites.","GO:0001508|action potential;GO:0001662|behavioral fear response;GO:0001666|response to hypoxia;GO:0001701|in utero embryonic development;GO:0001964|startle response;GO:0001967|suckling behavior;GO:0001975|response to amphetamine;GO:0006812|cation transport;GO:0006816|calcium ion transport;GO:0007268|chemical synaptic transmission;GO:0007423|sensory organ development;GO:0007611|learning or memory;GO:0007612|learning;GO:0007613|memory;GO:0007616|long-term memory;GO:0008306|associative learning;GO:0009612|response to mechanical stimulus;GO:0009636|response to toxic substance;GO:0009743|response to carbohydrate;GO:0010042|response to manganese ion;GO:0010243|response to organonitrogen compound;GO:0010350|cellular response to magnesium starvation;GO:0010738|regulation of protein kinase A signaling;GO:0010942|positive regulation of cell death;GO:0014049|positive regulation of glutamate secretion;GO:0014070|response to organic cyclic compound;GO:0014075|response to amine;GO:0019722|calcium-mediated signaling;GO:0021766|hippocampus development;GO:0021987|cerebral cortex development;GO:0032026|response to magnesium ion;GO:0033555|multicellular organismal response to stress;GO:0034097|response to cytokine;GO:0035235|ionotropic glutamate receptor signaling pathway;GO:0042220|response to cocaine;GO:0042596|fear response;GO:0043113|receptor clustering;GO:0043408|regulation of MAPK cascade;GO:0045471|response to ethanol;GO:0046960|sensitization;GO:0048167|regulation of synaptic plasticity;GO:0048169|regulation of long-term neuronal synaptic plasticity;GO:0048266|behavioral response to pain;GO:0048511|rhythmic process;GO:0050806|positive regulation of synaptic transmission;GO:0050966|detection of mechanical stimulus involved in sensory perception of pain;GO:0051290|protein heterotetramerization;GO:0051592|response to calcium ion;GO:0051597|response to methylmercury;GO:0051602|response to electrical stimulus;GO:0051707|response to other organism;GO:0060078|regulation of postsynaptic membrane potential;GO:0060079|excitatory postsynaptic potential;GO:0060291|long-term synaptic potentiation;GO:0060416|response to growth hormone;GO:0060992|response to fungicide;GO:0071230|cellular response to amino acid stimulus;GO:0071287|cellular response to manganese ion;GO:0071359|cellular response to dsRNA;GO:0071363|cellular response to growth factor stimulus;GO:0071386|cellular response to corticosterone stimulus;GO:0071396|cellular response to lipid;GO:0071407|cellular response to organic cyclic compound;GO:0097553|calcium ion transmembrane import into cytosol;GO:0098989|NMDA selective glutamate receptor signaling pathway;GO:0099566|regulation of postsynaptic cytosolic calcium ion concentration;GO:1901216|positive regulation of neuron death;GO:1902951|negative regulation of dendritic spine maintenance;GO:1904322|cellular response to forskolin;GO:1904644|cellular response to curcumin;GO:2001056|positive regulation of cysteine-type endopeptidase activity;","GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0005770|late endosome;GO:0005789|endoplasmic reticulum membrane;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0008021|synaptic vesicle;GO:0009986|cell surface;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0017146|NMDA selective glutamate receptor complex;GO:0030018|Z disc;GO:0042734|presynaptic membrane;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043083|synaptic cleft;GO:0043195|terminal bouton;GO:0043197|dendritic spine;GO:0044307|dendritic branch;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0097060|synaptic membrane;GO:0097440|apical dendrite;GO:0098686|hippocampal mossy fiber to CA3 synapse;GO:0098688|parallel fiber to Purkinje cell synapse;GO:0098794|postsynapse;GO:0098839|postsynaptic density membrane;GO:0098978|glutamatergic synapse;GO:0099056|integral component of presynaptic membrane;GO:0099061|integral component of postsynaptic density membrane;","GO:0004970|ionotropic glutamate receptor activity;GO:0004972|NMDA glutamate receptor activity;GO:0005102|signaling receptor binding;GO:0005149|interleukin-1 receptor binding;GO:0005234|extracellularly glutamate-gated ion channel activity;GO:0005261|cation channel activity;GO:0005262|calcium channel activity;GO:0005515|protein binding;GO:0008013|beta-catenin binding;GO:0008270|zinc ion binding;GO:0015276|ligand-gated ion channel activity;GO:0016594|glycine binding;GO:0016595|glutamate binding;GO:0022849|glutamate-gated calcium ion channel activity;GO:0031749|D2 dopamine receptor binding;GO:0035255|ionotropic glutamate receptor binding;GO:0036094|small molecule binding;GO:0038023|signaling receptor activity;GO:0042165|neurotransmitter binding;GO:0044877|protein-containing complex binding;GO:0050839|cell adhesion molecule binding;GO:0097110|scaffold protein binding;GO:0099529|neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential;GO:0099583|neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration;GO:1901363|heterocyclic compound binding;GO:1904315|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K05210","GRIN2B; glutamate receptor ionotropic, NMDA 2B"]
["ENSRNOG00000005299",143,12.03134342,479,30.81427989,0.390447009,-1.356801334,{"v":3.1953e-27,"d":"3.20E-27"},{"v":1.21834E-26,"d":"1.22E-26"},"down","yes","Kif5a","protein_coding","chr7:63049424-63092858:-","gi|47058980|ref|NP_997688.1|",4979,0,"kinesin heavy chain isoform 5A [Rattus norvegicus]","gi|298898969|emb|FQ212220.1|",5952,0,"Rattus norvegicus TL0AAA65YC10 mRNA sequence","Q6QLM7",1922,0,"Kinesin heavy chain isoform 5A","SPAC1834.07",323,{"v":1e-94,"d":"1.00E-94"},"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0007017|microtubule-based process;GO:0007018|microtubule-based movement;GO:0007411|axon guidance;GO:0016192|vesicle-mediated transport;GO:0021766|hippocampus development;GO:0021794|thalamus development;GO:0021987|cerebral cortex development;GO:0030705|cytoskeleton-dependent intracellular transport;GO:0048489|synaptic vesicle transport;GO:0048666|neuron development;GO:0071361|cellular response to ethanol;GO:0098971|anterograde dendritic transport of neurotransmitter receptor complex;GO:0099641|anterograde axonal protein transport;GO:1904647|response to rotenone;GO:1990049|retrograde neuronal dense core vesicle transport;GO:1990090|cellular response to nerve growth factor stimulus;","GO:0000932|P-body;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005871|kinesin complex;GO:0005874|microtubule;GO:0030424|axon;GO:0030425|dendrite;GO:0032839|dendrite cytoplasm;GO:0035253|ciliary rootlet;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0048471|perinuclear region of cytoplasm;GO:0090724|central region of growth cone;GO:0097440|apical dendrite;GO:1904115|axon cytoplasm;","GO:0003777|microtubule motor activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0008017|microtubule binding;GO:0008574|ATP-dependent microtubule motor activity, plus-end-directed;GO:0016887|ATPase activity;GO:0019894|kinesin binding;GO:0044877|protein-containing complex binding;GO:0097110|scaffold protein binding;","K10396","KIF5; kinesin family member 5"]
["ENSRNOG00000008709",286,24.06268683,755,48.56948083,0.495428125,-1.013252323,{"v":5.68508e-27,"d":"5.69E-27"},{"v":2.14217E-26,"d":"2.14E-26"},"down","yes","Arhgap32","protein_coding","chr8:30421515-30678454:+","gi|672022663|ref|XP_006226422.2|",10068,0,"PREDICTED: rho GTPase-activating protein 32 isoform X4 [Rattus norvegicus]","gi|672022666|ref|XM_008776684.1|",6304,0,"PREDICTED: Rattus norvegicus Rho GTPase activating protein 32 (Arhgap32), transcript variant X7, mRNA","Q811P8",3701,0,"Rho GTPase-activating protein 32",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0007264|small GTPase mediated signal transduction;GO:0050790|regulation of catalytic activity;","GO:0001650|fibrillar center;GO:0005654|nucleoplasm;GO:0005794|Golgi apparatus;GO:0005938|cell cortex;GO:0014069|postsynaptic density;GO:0015629|actin cytoskeleton;","GO:0005096|GTPase activator activity;GO:1901981|phosphatidylinositol phosphate binding;","K20647","ARHGAP32; Rho GTPase-activating protein 32"]
["ENSRNOG00000005960",143,12.03134342,477,30.68561901,0.392084103,-1.350764945,{"v":6.08897E-27,"d":"6.09E-27"},{"v":2.29119e-26,"d":"2.29E-26"},"down","yes","RGD1311744","protein_coding","chr8:39870563-39893187:-","gi|149041357|gb|EDL95198.1|",3901,0,"similar to RIKEN cDNA 5830475I06 (predicted), isoform CRA_a [Rattus norvegicus]","gi|672022710|ref|XR_085895.4|",3473,0,"PREDICTED: Rattus norvegicus similar to RIKEN cDNA 5830475I06 (RGD1311744), misc_RNA","O00534",907,0,"von Willebrand factor A domain-containing protein 5A","alr4412",64.7,1e-09,"COG2304","pfam13768","VWA_3","von Willebrand factor type A domain.",".",".",".",".","."]
["ENSRNOG00000006653",67,5.637062999,308,19.81377496,0.284502222,-1.813488176,{"v":1.00447E-26,"d":"1.00E-26"},{"v":3.75115E-26,"d":"3.75E-26"},"down","yes","Slc38a4","protein_coding","chr7:128144807-128202995:-","gi|18543357|ref|NP_570104.1|",2680,0,"sodium-coupled neutral amino acid transporter 4 [Rattus norvegicus]","gi|66910541|gb|BC097292.1|",1929,0,"Rattus norvegicus solute carrier family 38, member 4, mRNA (cDNA clone MGC:114273 IMAGE:7462761), complete cds","Q9EQ25",1036,0,"Sodium-coupled neutral amino acid transporter 4","YEL064c",65.9,{"v":2e-10,"d":"2.00E-10"},"COG0814","pfam01490","Aa_trans","Transmembrane amino acid transporter protein. This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.","GO:0003333|amino acid transmembrane transport;GO:0006814|sodium ion transport;","GO:0005887|integral component of plasma membrane;","GO:0015171|amino acid transmembrane transporter activity;GO:0015293|symporter activity;","K14991","SLC38A4, SNAT4; solute carrier family 38 (sodium-coupled neutral amino acid transporter), member 4"]
["ENSRNOG00000019428",221,18.59389437,630,40.52817606,0.458789321,-1.124096284,{"v":1.12625E-26,"d":"1.13E-26"},{"v":4.19444E-26,"d":"4.19E-26"},"down","yes","Higd1a","protein_coding","chr8:121514156-121523443:-","gi|61889108|ref|NP_543178.2|",493,{"v":6E-57,"d":"6.00E-57"},"HIG1 domain family member 1A, mitochondrial [Rattus norvegicus]","gi|402743435|ref|NM_080902.4|",1408,0,"Rattus norvegicus HIG1 hypoxia inducible domain family, member 1A (Higd1a), mRNA","Q8VH49",194,{"v":2e-58,"d":"2.00E-58"},"HIG1 domain family member 1A, mitochondrial",".",".",".",".","pfam04588","HIG_1_N","Hypoxia induced protein conserved region. This family is found in proteins thought to be involved in the response to hypoxia. Family members mostly come from diverse eukaryotic organisms however eubacterial members have been identified. This region is found at the N-terminus of the member proteins which are predicted to be transmembrane.","GO:0042149|cellular response to glucose starvation;GO:0043066|negative regulation of apoptotic process;GO:0071456|cellular response to hypoxia;GO:0071902|positive regulation of protein serine/threonine kinase activity;GO:0090201|negative regulation of release of cytochrome c from mitochondria;GO:0097250|mitochondrial respiratory chain supercomplex assembly;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0032991|protein-containing complex;GO:0070469|respiratory chain;",".",".","."]
["ENSRNOG00000017693",46,3.870222358,255,16.40426174,0.235927859,-2.083582306,{"v":1.32242e-26,"d":"1.32E-26"},{"v":4.91829E-26,"d":"4.92E-26"},"down","yes","Slc2a5","protein_coding","chr5:160583234-160611106:+","gi|1170105|sp|P43427.1|GTR5_RAT",2387,0,"RecName: Full=Solute carrier family 2, facilitated glucose transporter member 5; AltName: Full=Fructose transporter; AltName: Full=Glucose transporter type 5, small intestine; Short=GLUT-5","gi|13929043|ref|NM_031741.1|",2142,0,"Rattus norvegicus solute carrier family 2 member 5 (Slc2a5), mRNA","P43427",924,0,"Solute carrier family 2, facilitated glucose transporter member 5",".",".",".",".","pfam00083","Sugar_tr","Sugar (and other) transporter.","GO:0003044|regulation of systemic arterial blood pressure mediated by a chemical signal;GO:0009750|response to fructose;GO:0015755|fructose transmembrane transport;GO:0071332|cellular response to fructose stimulus;GO:1904659|glucose transmembrane transport;GO:1990539|fructose import across plasma membrane;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0016324|apical plasma membrane;GO:0042383|sarcolemma;","GO:0005353|fructose transmembrane transporter activity;GO:0005355|glucose transmembrane transporter activity;GO:0070061|fructose binding;","K08143","SLC2A5, GLUT5; MFS transporter, SP family, solute carrier family 2 (facilitated glucose/fructose transporter), member 5"]
["ENSRNOG00000002802",87,7.319768372,353,22.70864468,0.322334004,-1.633371703,{"v":1.82752e-26,"d":"1.83E-26"},{"v":6.76447e-26,"d":"6.76E-26"},"down","yes","Cxcl1","protein_coding","chr14:17193365-17195215:-","gi|13540652|ref|NP_110472.1|",442,{"v":5E-51,"d":"5.00E-51"},"growth-regulated alpha protein precursor [Rattus norvegicus]","gi|13540651|ref|NM_030845.1|",909,0,"Rattus norvegicus chemokine (C-X-C motif) ligand 1 (Cxcl1), mRNA","P14095",174,{"v":2E-52,"d":"2.00E-52"},"Growth-regulated alpha protein",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0001975|response to amphetamine;GO:0002526|acute inflammatory response;GO:0006952|defense response;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007165|signal transduction;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0009408|response to heat;GO:0010332|response to gamma radiation;GO:0010765|positive regulation of sodium ion transport;GO:0030593|neutrophil chemotaxis;GO:0031640|killing of cells of other organism;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0032930|positive regulation of superoxide anion generation;GO:0043268|positive regulation of potassium ion transport;GO:0051384|response to glucocorticoid;GO:0060326|cell chemotaxis;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098|chemokine-mediated signaling pathway;GO:0070965|positive regulation of neutrophil mediated killing of fungus;GO:0071222|cellular response to lipopolysaccharide;GO:1902035|positive regulation of hematopoietic stem cell proliferation;","GO:0005615|extracellular space;","GO:0008009|chemokine activity;GO:0008083|growth factor activity;GO:0045236|CXCR chemokine receptor binding;","K05505","CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3"]
["ENSRNOG00000058271",97,8.161121059,375,24.12391432,0.338300035,-1.563624768,{"v":2.1257e-26,"d":"2.13E-26"},{"v":7.84685e-26,"d":"7.85E-26"},"down","yes","Chpt1","protein_coding","chr7:22863027-22915103:-","gi|564358905|ref|XP_006241290.1|",2328,0,"PREDICTED: cholinephosphotransferase 1 isoform X1 [Rattus norvegicus]","gi|672058253|ref|XM_006241228.2|",1540,0,"PREDICTED: Rattus norvegicus choline phosphotransferase 1 (Chpt1), transcript variant X1, mRNA","Q66H21",717,0,"Cholinephosphotransferase 1","SPAC22A12.10",118,{"v":1E-27,"d":"1.00E-27"},"COG5050","pfam01066","CDP-OH_P_transf","CDP-alcohol phosphatidyltransferase. All of these members have the ability to catalyse the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.","GO:0006656|phosphatidylcholine biosynthetic process;GO:0006657|CDP-choline pathway;GO:0006663|platelet activating factor biosynthetic process;","GO:0000139|Golgi membrane;GO:0005789|endoplasmic reticulum membrane;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;","GO:0004142|diacylglycerol cholinephosphotransferase activity;GO:0016780|phosphotransferase activity, for other substituted phosphate groups;GO:0046872|metal ion binding;","K00994","CHPT1, CPT1; diacylglycerol cholinephosphotransferase [EC:2.7.8.2]"]
["ENSRNOG00000067139",35,2.944734403,224,14.41001815,0.204353275,-2.29086273,{"v":2.59205E-26,"d":"2.59E-26"},{"v":9.55537e-26,"d":"9.56E-26"},"down","yes","Rpl10l","protein_coding","chr6:84543540-84545816:-","gi|946668211|ref|XP_014419151.1|",1145,{"v":5e-149,"d":"5.00E-149"},"PREDICTED: 60S ribosomal protein L10 isoform X1 [Camelus ferus]","gi|22296791|gb|AC125344.2|",1308,0,"Mus musculus BAC clone RP24-332H21 from 12, complete sequence","P86048",443,{"v":7e-150,"d":"7.00E-150"},"60S ribosomal protein L10-like","SPAP7G5.05",315,{"v":1E-100,"d":"1.00E-100"},"COG0197","pfam00252","Ribosomal_L16","Ribosomal protein L16p/L10e.",".",".",".",".","."]
["ENSRNOG00000005275",127,10.68517912,438,28.17673192,0.379219959,-1.398893198,{"v":3.8045e-26,"d":"3.80E-26"},{"v":1.39494E-25,"d":"1.39E-25"},"down","yes","Shmt1","protein_coding","chr10:45468700-45497820:-","gi|114326177|ref|NP_001041307.1|",3618,0,"serine hydroxymethyltransferase, cytosolic [Rattus norvegicus]","gi|114326176|ref|NM_001047842.1|",2046,0,"Rattus norvegicus serine hydroxymethyltransferase 1 (soluble) (Shmt1), mRNA","P50431",949,0,"Serine hydroxymethyltransferase, cytosolic","YLR058c",540,0,"COG0112","pfam00464","SHMT","Serine hydroxymethyltransferase.","GO:0006231|dTMP biosynthetic process;GO:0006544|glycine metabolic process;GO:0006545|glycine biosynthetic process;GO:0006563|L-serine metabolic process;GO:0006565|L-serine catabolic process;GO:0006730|one-carbon metabolic process;GO:0009113|purine nucleobase biosynthetic process;GO:0017148|negative regulation of translation;GO:0019264|glycine biosynthetic process from serine;GO:0035999|tetrahydrofolate interconversion;GO:0046653|tetrahydrofolate metabolic process;GO:0046655|folic acid metabolic process;GO:0051289|protein homotetramerization;GO:1904482|cellular response to tetrahydrofolate;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0000900|translation repressor activity, mRNA regulatory element binding;GO:0004372|glycine hydroxymethyltransferase activity;GO:0008270|zinc ion binding;GO:0008732|L-allo-threonine aldolase activity;GO:0016597|amino acid binding;GO:0030170|pyridoxal phosphate binding;GO:0036094|small molecule binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0048027|mRNA 5'-UTR binding;GO:0050897|cobalt ion binding;GO:0070905|serine binding;","K00600","glyA, SHMT; glycine hydroxymethyltransferase [EC:2.1.2.1]"]
["ENSRNOG00000025245",184,15.48088943,553,35.57473232,0.43516531,-1.200364539,{"v":4.80936e-26,"d":"4.81E-26"},{"v":1.75983e-25,"d":"1.76E-25"},"down","yes","RGD1311946","protein_coding","chr1:200945180-200962585:+","gi|71043854|ref|NP_001020854.1|",868,{"v":1e-104,"d":"1.00E-104"},"uncharacterized protein C11orf24 homolog precursor [Rattus norvegicus]","gi|71043853|ref|NM_001025683.1|",2067,0,"Rattus norvegicus similar to RIKEN cDNA 1810055G02 (RGD1311946), mRNA","Q4V7A5",338,{"v":3e-106,"d":"3.00E-106"},"Uncharacterized protein C11orf24 homolog",".",".",".",".","pfam05109","Herpes_BLLF1","Herpes virus major outer envelope glycoprotein (BLLF1). This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralizing antibodies in vivo.",".","GO:0005654|nucleoplasm;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;",".",".","."]
["ENSRNOG00000047653",23,1.935111179,188,12.09412238,0.160004266,-2.643817721,{"v":4.80938e-26,"d":"4.81E-26"},{"v":1.75983e-25,"d":"1.76E-25"},"down","yes","Crybb1","protein_coding","chr12:44369735-44383344:-","gi|568935244|ref|XP_006534815.1|",1039,{"v":3e-137,"d":"3.00E-137"},"PREDICTED: beta-crystallin B1 isoform X2 [Mus musculus]","gi|162287072|ref|NM_012936.2|",979,0,"Rattus norvegicus crystallin, beta B1 (Crybb1), mRNA","Q9WVJ5",391,{"v":3e-135,"d":"3.00E-135"},"Beta-crystallin B1",".",".",".",".","pfam00030","Crystall","Beta/Gamma crystallin. The alignment comprises two Greek key motifs since the similarity between them is very low.","GO:0002088|lens development in camera-type eye;GO:0007601|visual perception;",".","GO:0005212|structural constituent of eye lens;","K23482","CRYB; beta-crystallin"]
["ENSRNOG00000070850",269,22.63238727,714,45.93193286,0.492737533,-1.021108727,{"v":6.66136e-26,"d":"6.66E-26"},{"v":2.42285e-25,"d":"2.42E-25"},"down","yes","ENSRNOG00000070850","lncRNA","chr10:65397702-65407712:+","gi|149053604|gb|EDM05421.1|",143,{"v":4e-16,"d":"4.00E-16"},"rCG32479 [Rattus norvegicus]","gi|564373469|ref|XR_357760.1|",3035,0,"PREDICTED: Rattus norvegicus zinc finger protein 207 (Zfp207), transcript variant X8, misc_RNA",".",".",".",".",".",".",".",".","pfam03053","Corona_NS3b","ORF3b coronavirus protein. Members of this family are non-structural proteins, approximately 250 amino acid residues long. They are found in transmissible gastroenteritis coronavirus (TGEV) and porcine respiratory coronavirus (PRCV) isolates. These proteins are found on the same mRNA as another product, designated ORF3a. While ORF3a/b has been implicated in TGEV and PRCV pathogenesis, its precise role remains unclear.",".",".",".",".","."]
["ENSRNOG00000012835",130,10.93758492,441,28.36972324,0.385537244,-1.375057858,{"v":1.1179E-25,"d":"1.12E-25"},{"v":4.04977e-25,"d":"4.05E-25"},"down","yes","Espl1","protein_coding","chr7:133424130-133450984:+","gi|282158055|ref|NP_001164073.1|",10127,0,"separin [Rattus norvegicus]","gi|282158054|ref|NM_001170602.1|",5291,0,"Rattus norvegicus extra spindle pole bodies like 1, separase (Espl1), mRNA","P60330",3487,0,"Separin","SPCC5E4.04",144,{"v":2e-33,"d":"2.00E-33"},"COG5155","pfam03568","Peptidase_C50","Peptidase family C50.","GO:0000070|mitotic sister chromatid segregation;GO:0000212|meiotic spindle organization;GO:0000278|mitotic cell cycle;GO:0006508|proteolysis;GO:0007059|chromosome segregation;GO:0007127|meiosis I;GO:0045143|homologous chromosome segregation;GO:0051307|meiotic chromosome separation;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0072686|mitotic spindle;","GO:0004197|cysteine-type endopeptidase activity;GO:0008233|peptidase activity;GO:0008234|cysteine-type peptidase activity;","K02365","ESP1; separase [EC:3.4.22.49]"]
["ENSRNOG00000045821",204,17.1635948,589,37.89062809,0.45297731,-1.142489307,{"v":1.15445E-25,"d":"1.15E-25"},{"v":4.17385e-25,"d":"4.17E-25"},"down","yes","Slc41a3","protein_coding","chr4:123112748-123154766:+","gi|564347800|ref|XP_006236933.1|",2228,0,"PREDICTED: solute carrier family 41 member 3 isoform X2 [Rattus norvegicus]","gi|672050458|ref|XM_006236871.2|",2129,0,"PREDICTED: Rattus norvegicus solute carrier family 41, member 3 (Slc41a3), transcript variant X1, mRNA","Q921R8",805,0,"Solute carrier family 41 member 3","MA1437",72.4,{"v":3e-13,"d":"3.00E-13"},"COG1824","pfam01769","MgtE","Divalent cation transporter. This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)","GO:0098655|cation transmembrane transport;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0008324|cation transmembrane transporter activity;","K15122","SLC41A; solute carrier family 41"]
["ENSRNOG00000027151",109,9.170744282,396,25.47485352,0.359992032,-1.473963121,{"v":1.31904E-25,"d":"1.32E-25"},{"v":4.75626e-25,"d":"4.76E-25"},"down","yes","Lrrc58","protein_coding","chr11:62847562-62862829:-","gi|312434031|ref|NP_001182487.1|",1198,{"v":2e-148,"d":"2.00E-148"},"leucine-rich repeat-containing protein 58 [Rattus norvegicus]","gi|110347494|ref|NM_177093.3|",1476,0,"Mus musculus leucine rich repeat containing 58 (Lrrc58), mRNA",".",".",".",".","alr0124_1",69.3,{"v":4e-11,"d":"4.00E-11"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.",".",".",".",".","."]
["ENSRNOG00000066023",160,13.46164298,501,32.22954953,0.417680147,-1.259529524,{"v":1.72932e-25,"d":"1.73E-25"},{"v":6.21922e-25,"d":"6.22E-25"},"down","yes","ENSRNOG00000066023","lncRNA","chr1:127300641-127316413:-","gi|149057184|gb|EDM08507.1|",174,{"v":6e-23,"d":"6.00E-23"},"rCG24770, isoform CRA_a [Rattus norvegicus]","gi|672037047|ref|XM_006229371.2|",1728,0,"PREDICTED: Rattus norvegicus chromodomain helicase DNA binding protein 2 (Chd2), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam00799","Gemini_AL1","Geminivirus Rep catalytic domain. The AL1 proteins encodes the replication initiator protein (Rep) of geminiviruses, which is a replicon-specific initiator enzyme and is an essential component of the replisome. For geminivirus Rep protein, this N-terminal region is crucial for origin recognition and DNA cleavage and nucleotidyl transfer.",".",".",".",".","."]
["ENSRNOG00000028243",111,9.33901482,398,25.6035144,0.364755192,-1.454999579,{"v":2.88637e-25,"d":"2.89E-25"},{"v":1.02852E-24,"d":"1.03E-24"},"down","yes","Derl3","protein_coding","chr20:12763543-12767027:-","gi|199560022|ref|NP_001103047.2|",869,{"v":1e-111,"d":"1.00E-111"},"derlin-3 [Rattus norvegicus]","gi|157818726|ref|NM_001109577.1|",1357,0,"Rattus norvegicus derlin 3 (Derl3), mRNA","Q9D8K3",333,{"v":7e-111,"d":"7.00E-111"},"Derlin-3","ECU11g1920",98.6,{"v":5e-22,"d":"5.00E-22"},"COG5291","pfam04511","DER1","Der1-like family. The endoplasmic reticulum (ER) of the yeast Saccharomyces cerevisiae contains of proteolytic system able to selectively degrade misfolded lumenal secretory proteins. For examination of the components involved in this degradation process, mutants were isolated. They could be divided into four complementation groups. The mutations led to stabilisation of two different substrates for this process. The mutant classes were called 'der' for 'degradation in the ER'. DER1 was cloned by complementation of the der1-2 mutation. The DER1 gene codes for a novel, hydrophobic protein, that is localized to the ER. Deletion of DER1 abolished degradation of the substrate proteins. The function of the Der1 protein seems to be specifically required for the degradation process associated with the ER. Interestingly this family seems distantly related to the Rhomboid family of membrane peptidases. Suggesting that this family may also mediate degradation of misfolded proteins (Bateman A pers. obs.).","GO:0018279|protein N-linked glycosylation via asparagine;GO:0030433|ubiquitin-dependent ERAD pathway;GO:0030968|endoplasmic reticulum unfolded protein response;GO:1904153|negative regulation of retrograde protein transport, ER to cytosol;","GO:0000839|Hrd1p ubiquitin ligase ERAD-L complex;GO:0030176|integral component of endoplasmic reticulum membrane;","GO:0005047|signal recognition particle binding;GO:0044877|protein-containing complex binding;GO:0051787|misfolded protein binding;GO:1990381|ubiquitin-specific protease binding;","K13989","DERL2_3; Derlin-2/3"]
["ENSRNOG00000070506",112,9.423150088,400,25.73217527,0.366201069,-1.449292093,{"v":3.02626E-25,"d":"3.03E-25"},{"v":1.07626e-24,"d":"1.08E-24"},"down","yes","Chst8","pseudogene","chr1:87294540-87435900:-","gi|157819451|ref|NP_001100974.1|",2062,0,"carbohydrate sulfotransferase 8 [Rattus norvegicus]","gi|172353768|ref|NM_001107504.2|",1646,0,"Rattus norvegicus carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 (Chst8), mRNA","Q8BQ86",772,0,"Carbohydrate sulfotransferase 8",".",".",".",".","pfam03567","Sulfotransfer_2","Sulfotransferase family. This family includes a variety of sulfotransferase enzymes. Chondroitin 6-sulfotransferase catalyses the transfer of sulfate to position 6 of the N-acetylgalactosamine residue of chondroitin. This family also includes Heparan sulfate 2-O-sulfotransferase (HS2ST) and Heparan sulfate 6-sulfotransferase (HS6ST). Heparan sulfate (HS) is a co-receptor for a number of growth factors, morphogens, and adhesion proteins. HS biosynthetic modifications may determine the strength and outcome of HS-ligand interactions. Mice that lack HS2ST undergo developmental failure only after midgestation,the most dramatic effect being the complete failure of kidney development. Heparan sulphate 6- O -sulfotransferase (HS6ST) catalyses the transfer of sulphate from adenosine 3'-phosphate, 5'-phosphosulphate to the 6th position of the N -sulphoglucosamine residue in heparan sulphate.",".",".",".",".","."]
["ENSRNOG00000016403",137,11.5265318,449,28.88436674,0.399057799,-1.325330377,{"v":9.0277e-25,"d":"9.03E-25"},{"v":3.1774E-24,"d":"3.18E-24"},"down","yes","Olah","protein_coding","chr17:74877655-74902518:+","gi|12083671|ref|NP_073196.1|",1365,0,"S-acyl fatty acid synthase thioesterase, medium chain [Rattus norvegicus]","gi|672082480|ref|XM_008771886.1|",1385,0,"PREDICTED: Rattus norvegicus oleoyl-ACP hydrolase (Olah), transcript variant X1, mRNA","P08635",530,0,"S-acyl fatty acid synthase thioesterase, medium chain","alr2045",145,{"v":5e-39,"d":"5.00E-39"},"COG3208","pfam00975","Thioesterase","Thioesterase domain. Peptide synthetases are involved in the non-ribosomal synthesis of peptide antibiotics. Next to the operons encoding these enzymes, in almost all cases, are genes that encode proteins that have similarity to the type II fatty acid thioesterases of vertebrates. There are also modules within the peptide synthetases that also share this similarity. With respect to antibiotic production, thioesterases are required for the addition of the last amino acid to the peptide antibiotic, thereby forming a cyclic antibiotic. Thioesterases (non-integrated) have molecular masses of 25-29 kDa.","GO:0008610|lipid biosynthetic process;GO:0051792|medium-chain fatty acid biosynthetic process;","GO:0005829|cytosol;","GO:0004320|oleoyl-[acyl-carrier-protein] hydrolase activity;GO:0016290|palmitoyl-CoA hydrolase activity;GO:0016295|myristoyl-[acyl-carrier-protein] hydrolase activity;GO:0016296|palmitoyl-[acyl-carrier-protein] hydrolase activity;GO:0016297|acyl-[acyl-carrier-protein] hydrolase activity;GO:0047381|dodecanoyl-[acyl-carrier-protein] hydrolase activity;GO:0102991|myristoyl-CoA hydrolase activity;","K01071","MCH; medium-chain acyl-[acyl-carrier-protein] hydrolase [EC:3.1.2.21]"]
["ENSRNOG00000031974",33,2.776463865,210,13.50939202,0.205521008,-2.282642224,{"v":1.13849e-24,"d":"1.14E-24"},{"v":3.99157e-24,"d":"3.99E-24"},"down","yes","Pcdh10","protein_coding","chr2:128617174-128677190:+","gi|148271088|ref|NP_001091642.1|",5258,0,"protocadherin-10 isoform 2 precursor [Mus musculus]","gi|148271087|ref|NM_001098172.1|",3785,0,"Mus musculus protocadherin 10 (Pcdh10), transcript variant 2, mRNA","Q9P2E7",1959,0,"Protocadherin-10",".",".",".",".","pfam08266","Cadherin_2","Cadherin-like. This cadherin domain is usually the most N-terminal copy of the domain.","GO:0007155|cell adhesion;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;","GO:0005887|integral component of plasma membrane;","GO:0005509|calcium ion binding;","K16499","PCDHD2; protocadherin delta 2"]
["ENSRNOG00000014844",184,15.48088943,542,34.8670975,0.443997079,-1.171377911,{"v":1.2002e-24,"d":"1.20E-24"},{"v":4.19982e-24,"d":"4.20E-24"},"down","yes","Kif21a","protein_coding","chr7:122062537-122178999:-","gi|672022268|ref|XP_008774783.1|",7979,0,"PREDICTED: kinesin-like protein KIF21A isoform X2 [Rattus norvegicus]","gi|672060488|ref|XM_008765828.1|",6312,0,"PREDICTED: Rattus norvegicus kinesin family member 21A (Kif21a), transcript variant X16, mRNA","Q9QXL2",2936,0,"Kinesin-like protein KIF21A","ECU05g0060_1",252,{"v":8e-71,"d":"8.00E-71"},"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0007018|microtubule-based movement;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005829|cytosol;GO:0005871|kinesin complex;GO:0005874|microtubule;GO:0005886|plasma membrane;","GO:0003674|molecular_function;GO:0003777|microtubule motor activity;GO:0005524|ATP binding;GO:0008017|microtubule binding;GO:0016887|ATPase activity;GO:0071532|ankyrin repeat binding;","K24185","KIF21; kinesin family member 21"]
["ENSRNOG00000022615",231,19.43524706,632,40.65683693,0.478031459,-1.064822532,{"v":1.2122e-24,"d":"1.21E-24"},{"v":4.23907e-24,"d":"4.24E-24"},"down","yes","Tp53i13","protein_coding","chr10:62356722-62361343:-","gi|157786660|ref|NP_001099288.1|",1280,{"v":5e-171,"d":"5.00E-171"},"tumor protein p53-inducible protein 13 precursor [Rattus norvegicus]","gi|157786659|ref|NM_001105818.1|",1392,0,"Rattus norvegicus tumor protein p53 inducible protein 13 (Tp53i13), mRNA","B0BN44",497,{"v":2e-172,"d":"2.00E-172"},"Tumor protein p53-inducible protein 13",".",".",".",".","pfam11303","DUF3105","Protein of unknown function (DUF3105). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.","GO:0009410|response to xenobiotic stimulus;GO:0009411|response to UV;GO:0014070|response to organic cyclic compound;GO:0045786|negative regulation of cell cycle;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000029986",107,9.002473745,385,24.7672187,0.363483436,-1.460038474,{"v":1.30007e-24,"d":"1.30E-24"},{"v":4.53763E-24,"d":"4.54E-24"},"down","yes","Insr","protein_coding","chr12:1197100-1330883:-","gi|298231200|ref|NP_058767.2|",7161,0,"insulin receptor preproprotein [Rattus norvegicus]","gi|298231199|ref|NM_017071.2|",5390,0,"Rattus norvegicus insulin receptor (Insr), mRNA","P15127",2749,0,"Insulin receptor","YAR019c",95.5,{"v":9e-19,"d":"9.00E-19"},"COG0515","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0000380|alternative mRNA splicing, via spliceosome;GO:0001666|response to hypoxia;GO:0001889|liver development;GO:0001933|negative regulation of protein phosphorylation;GO:0001934|positive regulation of protein phosphorylation;GO:0002092|positive regulation of receptor internalization;GO:0003007|heart morphogenesis;GO:0006111|regulation of gluconeogenesis;GO:0006355|regulation of transcription, DNA-templated;GO:0006468|protein phosphorylation;GO:0006898|receptor-mediated endocytosis;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007275|multicellular organism development;GO:0008284|positive regulation of cell proliferation;GO:0008286|insulin receptor signaling pathway;GO:0008544|epidermis development;GO:0008584|male gonad development;GO:0009725|response to hormone;GO:0009749|response to glucose;GO:0009887|animal organ morphogenesis;GO:0010033|response to organic substance;GO:0010042|response to manganese ion;GO:0010310|regulation of hydrogen peroxide metabolic process;GO:0010560|positive regulation of glycoprotein biosynthetic process;GO:0010629|negative regulation of gene expression;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0014823|response to activity;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0021549|cerebellum development;GO:0021766|hippocampus development;GO:0030238|male sex determination;GO:0030325|adrenal gland development;GO:0030335|positive regulation of cell migration;GO:0031017|exocrine pancreas development;GO:0031667|response to nutrient levels;GO:0032094|response to food;GO:0032147|activation of protein kinase activity;GO:0032148|activation of protein kinase B activity;GO:0032355|response to estradiol;GO:0032410|negative regulation of transporter activity;GO:0032868|response to insulin;GO:0032869|cellular response to insulin stimulus;GO:0033280|response to vitamin D;GO:0033574|response to testosterone;GO:0033674|positive regulation of kinase activity;GO:0034612|response to tumor necrosis factor;GO:0038083|peptidyl-tyrosine autophosphorylation;GO:0042327|positive regulation of phosphorylation;GO:0042593|glucose homeostasis;GO:0042594|response to starvation;GO:0043243|positive regulation of protein complex disassembly;GO:0043406|positive regulation of MAP kinase activity;GO:0043410|positive regulation of MAPK cascade;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0045444|fat cell differentiation;GO:0045471|response to ethanol;GO:0045719|negative regulation of glycogen biosynthetic process;GO:0045725|positive regulation of glycogen biosynthetic process;GO:0045821|positive regulation of glycolytic process;GO:0045840|positive regulation of mitotic nuclear division;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045995|regulation of embryonic development;GO:0046326|positive regulation of glucose import;GO:0046777|protein autophosphorylation;GO:0048639|positive regulation of developmental growth;GO:0051384|response to glucocorticoid;GO:0051446|positive regulation of meiotic cell cycle;GO:0051897|positive regulation of protein kinase B signaling;GO:0060267|positive regulation of respiratory burst;GO:0071363|cellular response to growth factor stimulus;GO:0097062|dendritic spine maintenance;GO:0097242|amyloid-beta clearance;GO:0097421|liver regeneration;GO:1902438|response to vanadate(3-);GO:1904638|response to resveratrol;GO:1990402|embryonic liver development;GO:1990535|neuron projection maintenance;GO:2000194|regulation of female gonad development;GO:2000252|negative regulation of feeding behavior;","GO:0005634|nucleus;GO:0005635|nuclear envelope;GO:0005764|lysosome;GO:0005768|endosome;GO:0005770|late endosome;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005899|insulin receptor complex;GO:0005901|caveola;GO:0009897|external side of plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0031410|cytoplasmic vesicle;GO:0031981|nuclear lumen;GO:0032590|dendrite membrane;GO:0032809|neuronal cell body membrane;GO:0043025|neuronal cell body;GO:0043231|intracellular membrane-bounded organelle;GO:0043235|receptor complex;GO:0044297|cell body;GO:0045202|synapse;GO:0060417|yolk;","GO:0001540|amyloid-beta binding;GO:0004672|protein kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0005009|insulin-activated receptor activity;GO:0005159|insulin-like growth factor receptor binding;GO:0005198|structural molecule activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0005525|GTP binding;GO:0019901|protein kinase binding;GO:0019903|protein phosphatase binding;GO:0019904|protein domain specific binding;GO:0031405|lipoic acid binding;GO:0031994|insulin-like growth factor I binding;GO:0031995|insulin-like growth factor II binding;GO:0038024|cargo receptor activity;GO:0042802|identical protein binding;GO:0043423|3-phosphoinositide-dependent protein kinase binding;GO:0043548|phosphatidylinositol 3-kinase binding;GO:0043559|insulin binding;GO:0043560|insulin receptor substrate binding;GO:0044877|protein-containing complex binding;GO:0051425|PTB domain binding;","K04527","INSR, CD220; insulin receptor [EC:2.7.10.1]"]
["ENSRNOG00000000515",126,10.60104385,424,27.27610579,0.388656795,-1.363431356,{"v":1.87505e-24,"d":"1.88E-24"},{"v":6.51521E-24,"d":"6.52E-24"},"down","yes","Mapk13","protein_coding","chr20:6835320-6844222:+","gi|149043487|gb|EDL96938.1|",1877,0,"mitogen activated protein kinase 13 [Rattus norvegicus]","gi|82524632|ref|NM_019231.2|",1634,0,"Rattus norvegicus mitogen activated protein kinase 13 (Mapk13), mRNA","Q9WTY9",726,0,"Mitogen-activated protein kinase 13",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006468|protein phosphorylation;GO:0006970|response to osmotic stress;GO:0018105|peptidyl-serine phosphorylation;GO:0032755|positive regulation of interleukin-6 production;GO:0034644|cellular response to UV;GO:0035556|intracellular signal transduction;GO:0051403|stress-activated MAPK cascade;GO:0070301|cellular response to hydrogen peroxide;GO:0071347|cellular response to interleukin-1;GO:0072709|cellular response to sorbitol;GO:0072740|cellular response to anisomycin;GO:1903936|cellular response to sodium arsenite;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0004674|protein serine/threonine kinase activity;GO:0004707|MAP kinase activity;GO:0005524|ATP binding;","K04441","P38; p38 MAP kinase [EC:2.7.11.24]"]
["ENSRNOG00000016724",163,13.71404879,499,32.10088865,0.427217107,-1.226958676,{"v":1.95121e-24,"d":"1.95E-24"},{"v":6.77553e-24,"d":"6.78E-24"},"down","yes","Epb41l3","protein_coding","chr9:109016113-109260607:+","gi|16758808|ref|NP_446379.1|",4985,0,"band 4.1-like protein 3 [Rattus norvegicus]","gi|16758807|ref|NM_053927.1|",4528,0,"Rattus norvegicus erythrocyte membrane protein band 4.1-like 3 (Epb41l3), mRNA","Q9Y2J2",1575,0,"Band 4.1-like protein 3",".",".",".",".","pfam05902","4_1_CTD","4.1 protein C-terminal domain (CTD). At the C-terminus of all known 4.1 proteins is a sequence domain unique to these proteins, known as the C-terminal domain (CTD). Mammalian CTDs are associated with a growing number of protein-protein interactions, although such activities have yet to be associated with invertebrate CTDs. Mammalian CTDs are generally defined by sequence alignment as encoded by exons 18-21. Comparison of known vertebrate 4.1 proteins with invertebrate 4.1 proteins indicates that mammalian 4.1 exon 19 represents a vertebrate adaptation that extends the sequence of the CTD with a Ser/Thr-rich sequence. The CTD was first described as a 22/24-kDa domain by chymotryptic digestion of erythrocyte 4.1 (4.1R). CTD is thought to represent an independent folding structure which has gained function since the divergence of vertebrates from invertebrates.","GO:0001558|regulation of cell growth;GO:0002175|protein localization to paranode region of axon;GO:0008360|regulation of cell shape;GO:0030866|cortical actin cytoskeleton organization;GO:0030913|paranodal junction assembly;GO:0031032|actomyosin structure organization;GO:0043217|myelin maintenance;GO:0048812|neuron projection morphogenesis;GO:0071205|protein localization to juxtaparanode region of axon;GO:0072659|protein localization to plasma membrane;","GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0014069|postsynaptic density;GO:0030054|cell junction;GO:0030673|axolemma;GO:0033270|paranode region of axon;GO:0044224|juxtaparanode region of axon;","GO:0003779|actin binding;GO:0005198|structural molecule activity;","K23961","EPB41L1_2_3; band 4.1-like protein 1/2/3"]
["ENSRNOG00000022309",58,4.879845581,272,17.49787919,0.278882116,-1.842272671,{"v":2.836e-24,"d":"2.84E-24"},{"v":9.77317e-24,"d":"9.77E-24"},"down","yes","Frem1","protein_coding","chr5:97322538-97469543:-","gi|300795821|ref|NP_001178686.1|",11472,0,"FRAS1-related extracellular matrix protein 1 precursor [Rattus norvegicus]","gi|300795820|ref|NM_001191757.1|",6630,0,"Rattus norvegicus Fras1 related extracellular matrix 1 (Frem1), mRNA","Q684R7",3979,0,"FRAS1-related extracellular matrix protein 1",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0007154|cell communication;GO:0007160|cell-matrix adhesion;GO:0008150|biological_process;GO:0097094|craniofacial suture morphogenesis;","GO:0005575|cellular_component;GO:0005604|basement membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;","K23380","FREM1_2; FRAS1-related extracelluar matrix protein 1/2"]
["ENSRNOG00000019584",54,4.543304507,261,16.79024437,0.270591923,-1.88580932,{"v":4.68162e-24,"d":"4.68E-24"},{"v":1.59917e-23,"d":"1.60E-23"},"down","yes","Dlk1","protein_coding","chr6:128410316-128417522:+","gi|16758572|ref|NP_446196.1|",1896,0,"protein delta homolog 1 precursor [Rattus norvegicus]","gi|189442750|gb|BC167752.1|",1562,0,"Rattus norvegicus delta-like 1 homolog (Drosophila), mRNA (cDNA clone MGC:187346 IMAGE:8365650), complete cds","Q09163",696,0,"Protein delta homolog 1",".",".",".",".","pfam00008","EGF","EGF-like domain. There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.","GO:0001503|ossification;GO:0001649|osteoblast differentiation;GO:0001819|positive regulation of cytokine production;GO:0009791|post-embryonic development;GO:0010468|regulation of gene expression;GO:0030154|cell differentiation;GO:0030282|bone mineralization;GO:0035264|multicellular organism growth;GO:0045599|negative regulation of fat cell differentiation;GO:0045746|negative regulation of Notch signaling pathway;GO:0045780|positive regulation of bone resorption;GO:0048706|embryonic skeletal system development;GO:1905563|negative regulation of vascular endothelial cell proliferation;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0009897|external side of plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;GO:0005515|protein binding;","K24461","DLK1; protein delta homolog 1"]
["ENSRNOG00000057794",125,10.51690858,418,26.89012316,0.391106746,-1.354365673,{"v":6.67646e-24,"d":"6.68E-24"},{"v":2.27486e-23,"d":"2.27E-23"},"down","yes","Adamts5","protein_coding","chr11:25000637-25047205:-","gi|149059749|gb|EDM10632.1|",4531,0,"a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) [Rattus norvegicus]","gi|298901989|emb|FQ228283.1|",3811,0,"Rattus norvegicus TL0AEA101YN20 mRNA sequence","Q9R001",1676,0,"A disintegrin and metalloproteinase with thrombospondin motifs 5",".",".",".",".","pfam05986","ADAM_spacer1","ADAM-TS Spacer 1. This family represents the Spacer-1 region from the ADAM-TS family of metalloproteinases.","GO:0006508|proteolysis;GO:0007229|integrin-mediated signaling pathway;GO:0007520|myoblast fusion;GO:0022617|extracellular matrix disassembly;GO:0030198|extracellular matrix organization;GO:0042742|defense response to bacterium;GO:0044691|tooth eruption;GO:0120163|negative regulation of cold-induced thermogenesis;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0031012|extracellular matrix;GO:0062023|collagen-containing extracellular matrix;","GO:0003674|molecular_function;GO:0004175|endopeptidase activity;GO:0004222|metalloendopeptidase activity;GO:0008201|heparin binding;GO:0008233|peptidase activity;GO:0008270|zinc ion binding;GO:0050840|extracellular matrix binding;","K08620","ADAMTS5; a disintegrin and metalloproteinase with thrombospondin motifs 5 [EC:3.4.24.-]"]
["ENSRNOG00000048433",243,20.44487028,648,41.68612394,0.49044786,-1.027828325,{"v":6.73814e-24,"d":"6.74E-24"},{"v":2.29444e-23,"d":"2.29E-23"},"down","yes","Tshz2","protein_coding","chr3:158405423-158850128:+","gi|564302924|ref|XP_006224810.1|",4823,0,"PREDICTED: teashirt homolog 2 [Rattus norvegicus]","gi|672048349|ref|XM_006235659.2|",3765,0,"PREDICTED: Rattus norvegicus teashirt zinc finger homeobox 2 (Tshz2), mRNA","Q68FE9",1800,0,"Teashirt homolog 2",".",".",".",".","pfam03154","Atrophin-1","Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.",".",".",".",".","."]
["ENSRNOG00000007332",107,9.002473745,380,24.44556651,0.368266112,-1.441179447,{"v":7.07921e-24,"d":"7.08E-24"},{"v":2.40757E-23,"d":"2.41E-23"},"down","yes","Sstr3","protein_coding","chr7:110092575-110099769:-","gi|19424168|ref|NP_598206.1|",1504,0,"somatostatin receptor type 3 [Rattus norvegicus]","gi|19424167|ref|NM_133522.1|",3826,0,"Rattus norvegicus somatostatin receptor 3 (Sstr3), mRNA","P30936",583,0,"Somatostatin receptor type 3",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007218|neuropeptide signaling pathway;GO:0007283|spermatogenesis;GO:0021549|cerebellum development;GO:0030900|forebrain development;GO:0038170|somatostatin signaling pathway;GO:0042594|response to starvation;GO:0060125|negative regulation of growth hormone secretion;GO:0071385|cellular response to glucocorticoid stimulus;GO:0071392|cellular response to estradiol stimulus;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005929|cilium;GO:0043005|neuron projection;GO:0060170|ciliary membrane;GO:0097730|non-motile cilium;","GO:0004930|G protein-coupled receptor activity;GO:0004994|somatostatin receptor activity;GO:0005102|signaling receptor binding;GO:0042277|peptide binding;GO:0042923|neuropeptide binding;","K04219","SSTR3; somatostatin receptor 3"]
["ENSRNOG00000006930",27,2.271652253,189,12.15845282,0.18683728,-2.420145747,{"v":7.44588e-24,"d":"7.45E-24"},{"v":2.53069e-23,"d":"2.53E-23"},"down","yes","Casq1","protein_coding","chr13:84670649-84680339:-","gi|227430324|ref|NP_001153066.1|",1829,0,"calsequestrin-1 precursor [Rattus norvegicus]","gi|227430323|ref|NM_001159594.1|",1848,0,"Rattus norvegicus calsequestrin 1 (Casq1), mRNA","P19633",710,0,"Calsequestrin-1",".",".",".",".","pfam01216","Calsequestrin","Calsequestrin.","GO:0007029|endoplasmic reticulum organization;GO:0007519|skeletal muscle tissue development;GO:0009408|response to heat;GO:0010033|response to organic substance;GO:0010880|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0014809|regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion;GO:0014870|response to muscle inactivity;GO:0014894|response to denervation involved in regulation of muscle adaptation;GO:0045214|sarcomere organization;GO:0051258|protein polymerization;GO:0051279|regulation of release of sequestered calcium ion into cytosol;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;GO:0051282|regulation of sequestering of calcium ion;GO:1901341|positive regulation of store-operated calcium channel activity;GO:2001256|regulation of store-operated calcium entry;","GO:0005737|cytoplasm;GO:0005759|mitochondrial matrix;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0014802|terminal cisterna;GO:0014804|terminal cisterna lumen;GO:0016529|sarcoplasmic reticulum;GO:0030016|myofibril;GO:0030018|Z disc;GO:0030315|T-tubule;GO:0031674|I band;GO:0033017|sarcoplasmic reticulum membrane;GO:0033018|sarcoplasmic reticulum lumen;GO:0042383|sarcolemma;GO:0043231|intracellular membrane-bounded organelle;","GO:0005509|calcium ion binding;GO:0042802|identical protein binding;","K23468","CASQ1; calsequestrin 1"]
["ENSRNOG00000008885",83,6.983227298,327,21.03605329,0.331964709,-1.590898219,{"v":8.87844e-24,"d":"8.88E-24"},{"v":3.0082e-23,"d":"3.01E-23"},"down","yes","Chst11","protein_coding","chr7:20528100-20743111:-","gi|564358828|ref|XP_006241262.1|",1882,0,"PREDICTED: carbohydrate sulfotransferase 11 isoform X1 [Rattus norvegicus]","gi|672058221|ref|XM_008765238.1|",2224,0,"PREDICTED: Rattus norvegicus carbohydrate (chondroitin 4) sulfotransferase 11 (Chst11), transcript variant X2, mRNA","P69478",722,0,"Carbohydrate sulfotransferase 11",".",".",".",".","pfam03567","Sulfotransfer_2","Sulfotransferase family. This family includes a variety of sulfotransferase enzymes. Chondroitin 6-sulfotransferase catalyses the transfer of sulfate to position 6 of the N-acetylgalactosamine residue of chondroitin. This family also includes Heparan sulfate 2-O-sulfotransferase (HS2ST) and Heparan sulfate 6-sulfotransferase (HS6ST). Heparan sulfate (HS) is a co-receptor for a number of growth factors, morphogens, and adhesion proteins. HS biosynthetic modifications may determine the strength and outcome of HS-ligand interactions. Mice that lack HS2ST undergo developmental failure only after midgestation,the most dramatic effect being the complete failure of kidney development. Heparan sulphate 6- O -sulfotransferase (HS6ST) catalyses the transfer of sulphate from adenosine 3'-phosphate, 5'-phosphosulphate to the 6th position of the N -sulphoglucosamine residue in heparan sulphate.","GO:0001701|in utero embryonic development;GO:0002063|chondrocyte development;GO:0007585|respiratory gaseous exchange;GO:0009791|post-embryonic development;GO:0016051|carbohydrate biosynthetic process;GO:0030166|proteoglycan biosynthetic process;GO:0030204|chondroitin sulfate metabolic process;GO:0030206|chondroitin sulfate biosynthetic process;GO:0030326|embryonic limb morphogenesis;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0033037|polysaccharide localization;GO:0036342|post-anal tail morphogenesis;GO:0042127|regulation of cell proliferation;GO:0042733|embryonic digit morphogenesis;GO:0043066|negative regulation of apoptotic process;GO:0048589|developmental growth;GO:0048703|embryonic viscerocranium morphogenesis;GO:0048704|embryonic skeletal system morphogenesis;GO:0051216|cartilage development;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0001537|N-acetylgalactosamine 4-O-sulfotransferase activity;GO:0008146|sulfotransferase activity;GO:0047756|chondroitin 4-sulfotransferase activity;GO:0050659|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity;","K01017","CHST11; chondroitin 4-sulfotransferase 11 [EC:2.8.2.5]"]
["ENSRNOG00000039076",217,18.2573533,598,38.46960203,0.474591686,-1.075241267,{"v":9.41439e-24,"d":"9.41E-24"},{"v":3.18582e-23,"d":"3.19E-23"},"down","yes","Spaca6","protein_coding","chr1:58677797-58688562:+","gi|209180413|ref|NP_001129192.1|",1607,0,"uncharacterized protein LOC688452 precursor [Rattus norvegicus]","gi|209180412|ref|NM_001135720.1|",1112,0,"Rattus norvegicus hypothetical protein LOC688452 (LOC688452), mRNA","E9Q8Q8",498,{"v":4E-175,"d":"4.00E-175"},"Sperm acrosome membrane-associated protein 6",".",".",".",".","pfam00047","ig","Immunoglobulin domain. Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions. The Pfam alignments do not include the first and last strand of the immunoglobulin-like domain.","GO:0007342|fusion of sperm to egg plasma membrane involved in single fertilization;","GO:0001669|acrosomal vesicle;GO:0016021|integral component of membrane;",".","K25514","SPACA6; sperm acrosome membrane-associated protein 6"]
["ENSRNOG00000065772",63,5.300521925,280,18.01252269,0.294268716,-1.764793919,{"v":1.33126e-23,"d":"1.33E-23"},{"v":4.47163e-23,"d":"4.47E-23"},"down","yes","ENSRNOG00000065772","protein_coding","chr17:74728811-74736094:+","gi|672030279|ref|XP_008772248.1|",1703,0,"PREDICTED: uncharacterized protein LOC102547897 [Rattus norvegicus]","gi|672030278|ref|XM_008774026.1|",2427,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102547897 (LOC102547897), mRNA","Q6AYB4",147,{"v":1E-35,"d":"1.00E-35"},"Heat shock 70 kDa protein 14","SPAC22A12.15c",80.1,{"v":2E-14,"d":"2.00E-14"},"COG0443","pfam00012","HSP70","Hsp70 protein. Hsp70 chaperones help to fold many proteins. Hsp70 assisted folding involves repeated cycles of substrate binding and release. Hsp70 activity is ATP dependent. Hsp70 proteins are made up of two regions: the amino terminus is the ATPase domain and the carboxyl terminus is the substrate binding region.",".",".",".",".","."]
["ENSRNOG00000070490",141,11.86307288,448,28.82003631,0.411625883,-1.280594395,{"v":1.59656E-23,"d":"1.60E-23"},{"v":5.33969e-23,"d":"5.34E-23"},"down","yes","ENSRNOG00000070490","lncRNA","chr3:56733057-56734666:-",".",".",".",".","gi|672045726|ref|XM_006234352.2|",1610,0,"PREDICTED: Rattus norvegicus pyruvate dehydrogenase kinase, isozyme 1 (Pdk1), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam00660","SRP1_TIP1","Seripauperin and TIP1 family.",".",".",".",".","."]
["ENSRNOG00000054695",104,8.750067939,371,23.86659257,0.366624097,-1.447626484,{"v":1.70317e-23,"d":"1.70E-23"},{"v":5.68576e-23,"d":"5.69E-23"},"down","yes","Calcrl","protein_coding","chr3:69430120-69525910:-","gi|6978587|ref|NP_036849.1|",2240,0,"calcitonin gene-related peptide type 1 receptor precursor [Rattus norvegicus]","gi|672046080|ref|XM_006234438.2|",3152,0,"PREDICTED: Rattus norvegicus calcitonin receptor-like (Calcrl), transcript variant X1, mRNA","Q63118",867,0,"Calcitonin gene-related peptide type 1 receptor",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0001525|angiogenesis;GO:0006816|calcium ion transport;GO:0007166|cell surface receptor signaling pathway;GO:0007188|adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007507|heart development;GO:0008284|positive regulation of cell proliferation;GO:0015031|protein transport;GO:0031623|receptor internalization;GO:0045986|negative regulation of smooth muscle contraction;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0050728|negative regulation of inflammatory response;GO:0071329|cellular response to sucrose stimulus;GO:1990408|calcitonin gene-related peptide receptor signaling pathway;GO:1990410|adrenomedullin receptor signaling pathway;","GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0005768|endosome;GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:1903143|adrenomedullin receptor complex;GO:1990406|CGRP receptor complex;","GO:0001605|adrenomedullin receptor activity;GO:0001635|calcitonin gene-related peptide receptor activity;GO:0004948|calcitonin receptor activity;GO:0008528|G protein-coupled peptide receptor activity;GO:1990409|adrenomedullin binding;","K04577","CALCRL; calcitonin receptor-like"]
["ENSRNOG00000023664",48,4.038492895,242,15.56796604,0.259410438,-1.946691562,{"v":2.52193e-23,"d":"2.52E-23"},{"v":8.32214e-23,"d":"8.32E-23"},"down","yes","Lepr","protein_coding","chr5:116289823-116475908:+","gi|149044573|gb|EDL97832.1|",6168,0,"rCG53475, isoform CRA_b [Rattus norvegicus]","gi|6981149|ref|NM_012596.1|",3611,0,"Rattus norvegicus leptin receptor (Lepr), mRNA","Q62959",2375,0,"Leptin receptor",".",".",".",".","pfam06328","Lep_receptor_Ig","Ig-like C2-type domain. This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.","GO:0001525|angiogenesis;GO:0001542|ovulation from ovarian follicle;GO:0001666|response to hypoxia;GO:0001934|positive regulation of protein phosphorylation;GO:0005977|glycogen metabolic process;GO:0006091|generation of precursor metabolites and energy;GO:0006909|phagocytosis;GO:0007565|female pregnancy;GO:0007568|aging;GO:0007584|response to nutrient;GO:0008203|cholesterol metabolic process;GO:0008584|male gonad development;GO:0010507|negative regulation of autophagy;GO:0014009|glial cell proliferation;GO:0019221|cytokine-mediated signaling pathway;GO:0019953|sexual reproduction;GO:0030217|T cell differentiation;GO:0033210|leptin-mediated signaling pathway;GO:0033993|response to lipid;GO:0035094|response to nicotine;GO:0035774|positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0042060|wound healing;GO:0042593|glucose homeostasis;GO:0042755|eating behavior;GO:0043410|positive regulation of MAPK cascade;GO:0043627|response to estrogen;GO:0044321|response to leptin;GO:0045721|negative regulation of gluconeogenesis;GO:0046850|regulation of bone remodeling;GO:0051049|regulation of transport;GO:0051346|negative regulation of hydrolase activity;GO:0060259|regulation of feeding behavior;GO:0071310|cellular response to organic substance;GO:0071548|response to dexamethasone;GO:0097009|energy homeostasis;GO:0098868|bone growth;GO:0120162|positive regulation of cold-induced thermogenesis;GO:1903999|negative regulation of eating behavior;GO:1904060|negative regulation of locomotor rhythm;","GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016328|lateral plasma membrane;GO:0043235|receptor complex;","GO:0004896|cytokine receptor activity;GO:0016500|protein-hormone receptor activity;GO:0017046|peptide hormone binding;GO:0019955|cytokine binding;GO:0038021|leptin receptor activity;GO:0042802|identical protein binding;","K05062","LEPR, CD295; leptin receptor"]
["ENSRNOG00000014538",60,5.048116119,271,17.43354875,0.289563312,-1.788049271,{"v":2.76583e-23,"d":"2.77E-23"},{"v":9.11595e-23,"d":"9.12E-23"},"down","yes","ENSRNOG00000014538","protein_coding","chr17:14031153-14036189:-","gi|281371342|ref|NP_001163900.1|",550,{"v":1E-62,"d":"1.00E-62"},"nucleoredoxin-like protein 2 [Rattus norvegicus]","gi|281371341|ref|NM_001170429.1|",587,0,"Rattus norvegicus nucleoredoxin-like 2 (Nxnl2), mRNA","Q9D531",206,{"v":1e-60,"d":"1.00E-60"},"Nucleoredoxin-like protein 2",".",".",".",".","pfam13905","Thioredoxin_8","Thioredoxin-like. Thioredoxins are small enzymes that participate in redox reactions, via the reversible oxidation of an active centre disulfide bond.","GO:0007601|visual perception;GO:0007608|sensory perception of smell;GO:0045494|photoreceptor cell maintenance;",".",".","K17609","NXN; nucleoredoxin [EC:1.8.1.8]"]
["ENSRNOG00000024346",68,5.721198268,289,18.59149664,0.307731991,-1.700253667,{"v":3.72039e-23,"d":"3.72E-23"},{"v":1.2181e-22,"d":"1.22E-22"},"down","yes","Plet1","protein_coding","chr8:50841854-50853659:+","gi|62079153|ref|NP_001014231.1|",945,{"v":2e-122,"d":"2.00E-122"},"placenta-expressed transcript 1 protein precursor [Rattus norvegicus]","gi|298910792|emb|FQ228964.1|",1325,0,"Rattus norvegicus TL0ADA50YB20 mRNA sequence","Q5HZW7",351,{"v":3e-117,"d":"3.00E-117"},"Placenta-expressed transcript 1 protein",".",".",".",".","pfam02112","PDEase_II","cAMP phosphodiesterases class-II.","GO:0001953|negative regulation of cell-matrix adhesion;GO:0030154|cell differentiation;GO:0030335|positive regulation of cell migration;GO:0035313|wound healing, spreading of epidermal cells;","GO:0009897|external side of plasma membrane;GO:0016324|apical plasma membrane;GO:0031225|anchored component of membrane;",".",".","."]
["ENSRNOG00000009712",222,18.67802964,602,38.72692379,0.482300886,-1.051994636,{"v":4.03986e-23,"d":"4.04E-23"},{"v":1.31873e-22,"d":"1.32E-22"},"down","yes","Gale","protein_coding","chr5:148194791-148198388:+","gi|672054325|ref|XP_008762419.1|",1881,0,"PREDICTED: UDP-glucose 4-epimerase isoform X2 [Rattus norvegicus]","gi|672054326|ref|XM_006239134.2|",1501,0,"PREDICTED: Rattus norvegicus UDP-galactose-4-epimerase (Gale), transcript variant X2, mRNA","Q8R059",714,0,"UDP-glucose 4-epimerase","SP1607",431,{"v":4e-147,"d":"4.00E-147"},"COG1087","pfam01370","Epimerase","NAD dependent epimerase/dehydratase family. This family of proteins utilize NAD as a cofactor. The proteins in this family use nucleotide-sugar substrates for a variety of chemical reactions.","GO:0006012|galactose metabolic process;GO:0019388|galactose catabolic process;GO:0033499|galactose catabolic process via UDP-galactose;","GO:0005829|cytosol;","GO:0003974|UDP-N-acetylglucosamine 4-epimerase activity;GO:0003978|UDP-glucose 4-epimerase activity;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;","K01784","galE, GALE; UDP-glucose 4-epimerase [EC:5.1.3.2]"]
["ENSRNOG00000006553",110,9.254879551,381,24.50989695,0.377597653,-1.405078299,{"v":4.25103e-23,"d":"4.25E-23"},{"v":1.386E-22,"d":"1.39E-22"},"down","yes","Bnc2","protein_coding","chr5:98687410-99079426:-","gi|625200748|ref|XP_007642184.1|",5342,0,"PREDICTED: zinc finger protein basonuclin-2 isoform X1 [Cricetulus griseus]","gi|672052839|ref|XM_008763775.1|",4086,0,"PREDICTED: Rattus norvegicus basonuclin 2 (Bnc2), transcript variant X1, mRNA","Q8BMQ3",2061,0,"Zinc finger protein basonuclin-2",".",".",".",".","pfam13894","zf-C2H2_4","C2H2-type zinc finger. This family contains a number of divergent C2H2 type zinc fingers.","GO:0003416|endochondral bone growth;GO:0006355|regulation of transcription, DNA-templated;GO:0043586|tongue development;GO:0060021|roof of mouth development;GO:0060485|mesenchyme development;","GO:0005634|nucleus;GO:0005654|nucleoplasm;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0003677|DNA binding;","K24146","BNC; zinc finger protein basonuclin"]
["ENSRNOG00000025273",209,17.58427115,577,37.11866283,0.473731266,-1.077859202,{"v":4.64052e-23,"d":"4.64E-23"},{"v":1.50937E-22,"d":"1.51E-22"},"down","yes","AABR07068728.1","protein_coding","chr9:108329669-108747774:+","gi|569000585|ref|XP_006524479.1|",3049,0,"PREDICTED: lethal(3)malignant brain tumor-like protein 4 isoform X1 [Mus musculus]","gi|569000586|ref|XM_006524417.1|",2080,0,"PREDICTED: Mus musculus l(3)mbt-like 4 (Drosophila) (L3mbtl4), transcript variant X2, mRNA","B1B1A0",1170,0,"Lethal(3)malignant brain tumor-like protein 4",".",".",".",".","pfam02820","MBT","mbt repeat. The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.",".",".",".",".","."]
["ENSRNOG00000050630",54,4.543304507,255,16.40426174,0.276958792,-1.85225676,{"v":5.15359e-23,"d":"5.15E-23"},{"v":1.67132E-22,"d":"1.67E-22"},"down","yes","AABR07070043.1","protein_coding","chr8:41698712-41717583:+","gi|8393418|ref|NP_058704.1|",1734,0,"glyceraldehyde-3-phosphate dehydrogenase [Rattus norvegicus]","gi|402691727|ref|NM_017008.4|",1197,0,"Rattus norvegicus glyceraldehyde-3-phosphate dehydrogenase (Gapdh), mRNA","P04797",672,0,"Glyceraldehyde-3-phosphate dehydrogenase","SPBC354.12",494,{"v":1E-172,"d":"1.00E-172"},"COG0057","pfam02800","Gp_dh_C","Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain. GAPDH is a tetrameric NAD-binding enzyme involved in glycolysis and glyconeogenesis. C-terminal domain is a mixed alpha/antiparallel beta fold.",".",".",".",".","."]
["ENSRNOG00000070249",95,7.992850521,348,22.38699249,0.357031009,-1.485878713,{"v":5.93724e-23,"d":"5.94E-23"},{"v":1.92082e-22,"d":"1.92E-22"},"down","yes","ENSRNOG00000070249","protein_coding","chr10:15309286-15309919:-","gi|392331680|ref|XP_002724712.2|",475,{"v":3E-57,"d":"3.00E-57"},"PREDICTED: hemoglobin subunit theta-1-like isoform X1 [Rattus norvegicus]","gi|672067068|ref|XM_002727758.4|",252,{"v":9e-128,"d":"9.00E-128"},"PREDICTED: Rattus norvegicus hemoglobin, theta 1B (Hbq1b), transcript variant X1, mRNA","P09105",140,{"v":3e-41,"d":"3.00E-41"},"Hemoglobin subunit theta-1",".",".",".",".","pfam00042","Globin","Globin.",".",".",".",".","."]
["ENSRNOG00000006698",138,11.61066707,437,28.11240149,0.413008724,-1.275755838,{"v":7.35852e-23,"d":"7.36E-23"},{"v":2.37077E-22,"d":"2.37E-22"},"down","yes","Rab33a","protein_coding","chrX:127694964-127706378:+","gi|332226374|ref|XP_003262364.1|",1362,0,"PREDICTED: ras-related protein Rab-33A [Nomascus leucogenys]","gi|157818280|ref|NM_001108257.1|",995,0,"Rattus norvegicus RAB33A, member RAS oncogene family (Rab33a), mRNA","Q14088",493,{"v":1E-175,"d":"1.00E-175"},"Ras-related protein Rab-33A",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0019882|antigen processing and presentation;GO:0032482|Rab protein signal transduction;","GO:0005768|endosome;GO:0005794|Golgi apparatus;","GO:0003924|GTPase activity;GO:0005525|GTP binding;","K07919","RAB33A; Ras-related protein Rab-33A"]
["ENSRNOG00000011775",28,2.355787522,186,11.9654615,0.196882295,-2.344594714,{"v":1.0598e-22,"d":"1.06E-22"},{"v":3.3884e-22,"d":"3.39E-22"},"down","yes","Mfap3l","protein_coding","chr16:29415849-29430863:-","gi|148696689|gb|EDL28636.1|",2166,0,"microfibrillar-associated protein 3-like, isoform CRA_b, partial [Mus musculus]","gi|58865673|ref|NM_001012049.1|",1925,0,"Rattus norvegicus microfibrillar-associated protein 3-like (Mfap3l), mRNA","Q6AYP2",801,0,"Microfibrillar-associated protein 3-like",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.",".","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030054|cell junction;",".","K25408","MFAP3L; microfibrillar-associated protein 3-like"]
["ENSRNOG00000031849",126,10.60104385,411,26.43981009,0.400950075,-1.318505485,{"v":1.21125E-22,"d":"1.21E-22"},{"v":3.86582e-22,"d":"3.87E-22"},"down","yes","Armh4","protein_coding","chr15:22975895-23076949:-","gi|157821419|ref|NP_001101844.1|",3639,0,"uncharacterized protein C14orf37 homolog [Rattus norvegicus]","gi|157821418|ref|NM_001108374.1|",3126,0,"Rattus norvegicus similar to 3632451O06Rik protein (RGD1310110), mRNA","Q8BT18",1116,0,"Armadillo-like helical domain-containing protein 4",".",".",".",".","pfam03546","Treacle","Treacher Collins syndrome protein Treacle.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000007949",34,2.860599134,201,12.93041808,0.221230212,-2.176379675,{"v":1.98861E-22,"d":"1.99E-22"},{"v":6.31721e-22,"d":"6.32E-22"},"down","yes","Rgn","protein_coding","chrX:1619032-1634450:-","gi|13928740|ref|NP_113734.1|",1597,0,"regucalcin [Rattus norvegicus]","gi|50927600|gb|BC078794.1|",1591,0,"Rattus norvegicus regucalcin (senescence marker protein-30), mRNA (cDNA clone MGC:93360 IMAGE:7126233), complete cds","Q03336",619,0,"Regucalcin","BS_yvrE",174,{"v":6E-49,"d":"6.00E-49"},"COG3386","pfam08450","SGL","SMP-30/Gluconolaconase/LRE-like region. This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.","GO:0001822|kidney development;GO:0001889|liver development;GO:0001933|negative regulation of protein phosphorylation;GO:0006469|negative regulation of protein kinase activity;GO:0006874|cellular calcium ion homeostasis;GO:0007283|spermatogenesis;GO:0007568|aging;GO:0010867|positive regulation of triglyceride biosynthetic process;GO:0010907|positive regulation of glucose metabolic process;GO:0010922|positive regulation of phosphatase activity;GO:0019853|L-ascorbic acid biosynthetic process;GO:0032515|negative regulation of phosphoprotein phosphatase activity;GO:0032781|positive regulation of ATPase activity;GO:0034260|negative regulation of GTPase activity;GO:0043066|negative regulation of apoptotic process;GO:0043547|positive regulation of GTPase activity;GO:0045019|negative regulation of nitric oxide biosynthetic process;GO:0045723|positive regulation of fatty acid biosynthetic process;GO:0050680|negative regulation of epithelial cell proliferation;GO:0050848|regulation of calcium-mediated signaling;GO:0051344|negative regulation of cyclic-nucleotide phosphodiesterase activity;GO:0097421|liver regeneration;GO:1901318|negative regulation of flagellated sperm motility;GO:1901671|positive regulation of superoxide dismutase activity;GO:1901896|positive regulation of calcium-transporting ATPase activity;GO:1902679|negative regulation of RNA biosynthetic process;GO:1903011|negative regulation of bone development;GO:1903052|positive regulation of proteolysis involved in cellular protein catabolic process;GO:1903611|negative regulation of calcium-dependent ATPase activity;GO:1903625|negative regulation of DNA catabolic process;GO:1903629|positive regulation of dUTP diphosphatase activity;GO:1903634|negative regulation of leucine-tRNA ligase activity;GO:2000279|negative regulation of DNA biosynthetic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004341|gluconolactonase activity;GO:0005509|calcium ion binding;GO:0008270|zinc ion binding;GO:0030234|enzyme regulator activity;","K01053","gnl, RGN; gluconolactonase [EC:3.1.1.17]"]
["ENSRNOG00000037076",111,9.33901482,378,24.31690563,0.384054409,-1.380617383,{"v":2.28215e-22,"d":"2.28E-22"},{"v":7.23701e-22,"d":"7.24E-22"},"down","yes","ENSRNOG00000037076","protein_coding","chr4:162098942-162109157:-","gi|396578136|ref|NP_001094489.2|",1081,{"v":6e-145,"d":"6.00E-145"},"C-type lectin domain family 2 member D3 [Rattus norvegicus]","gi|672051243|ref|XM_008763332.1|",877,0,"PREDICTED: Rattus norvegicus similar to osteoclast inhibitory lectin (LOC689757), transcript variant X1, mRNA","A4KWA6",413,{"v":1e-143,"d":"1.00E-143"},"C-type lectin domain family 2 member D3",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type",".","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0030246|carbohydrate binding;GO:0046703|natural killer cell lectin-like receptor binding;",".","."]
["ENSRNOG00000032311",28,2.355787522,184,11.83680063,0.19902232,-2.328997859,{"v":2.61321E-22,"d":"2.61E-22"},{"v":8.26758e-22,"d":"8.27E-22"},"down","yes","Ttll8","protein_coding","chr7:120001794-120045075:-","gi|295293121|ref|NP_766406.2|",3797,0,"protein monoglycylase TTLL8 [Mus musculus]","gi|672060698|ref|XR_593743.1|",2612,0,"PREDICTED: Rattus norvegicus similar to RIKEN cDNA 1700019P01 (RGD1306462), transcript variant X2, misc_RNA","A4Q9F1",1467,0,"Protein monoglycylase TTLL8",".",".",".",".","pfam03133","TTL","Tubulin-tyrosine ligase family. Tubulins and microtubules are subjected to several post-translational modifications of which the reversible detyrosination/tyrosination of the carboxy-terminal end of most alpha-tubulins has been extensively analysed. This modification cycle involves a specific carboxypeptidase and the activity of the tubulin-tyrosine ligase (TTL). The true physiological function of TTL has so far not been established. Tubulin-tyrosine ligase (TTL) catalyses the ATP-dependent post-translational addition of a tyrosine to the carboxy terminal end of detyrosinated alpha-tubulin. In normally cycling cells, the tyrosinated form of tubulin predominates. However, in breast cancer cells, the detyrosinated form frequently predominates, with a correlation to tumor aggressiveness. On the other hand, 3-nitrotyrosine has been shown to be incorporated, by TTL, into the carboxy terminal end of detyrosinated alpha-tubulin. This reaction is not reversible by the carboxypeptidase enzyme. Cells cultured in 3-nitrotyrosine rich medium showed evidence of altered microtubule structure and function, including altered cell morphology, epithelial barrier dysfunction, and apoptosis. Bacterial homologs of TTL are predicted to form peptide tags. Some of these are fused to a 2-oxoglutarate Fe(II)-dependent dioxygenase domain.",".",".",".",".","."]
["ENSRNOG00000011323",35,2.944734403,203,13.05907895,0.225493269,-2.148843726,{"v":2.65193e-22,"d":"2.65E-22"},{"v":8.38034e-22,"d":"8.38E-22"},"down","yes","Lgi3","protein_coding","chr15:45605611-45612739:+","gi|157822677|ref|NP_001100747.1|",2702,0,"leucine-rich repeat LGI family member 3 precursor [Rattus norvegicus]","gi|157822676|ref|NM_001107277.1|",3319,0,"Rattus norvegicus leucine-rich repeat LGI family, member 3 (Lgi3), mRNA","Q8K406",1030,0,"Leucine-rich repeat LGI family member 3",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.","GO:0017157|regulation of exocytosis;","GO:0005576|extracellular region;GO:0008021|synaptic vesicle;","GO:0003824|catalytic activity;","K19999","LGI3; leucine-rich repeat LGI family member 3"]
["ENSRNOG00000062470",132,11.10585546,420,27.01878404,0.411042016,-1.282642224,{"v":3.3244E-22,"d":"3.32E-22"},{"v":1.0475e-21,"d":"1.05E-21"},"down","yes","ENSRNOG00000062470","lncRNA","chr18:76385516-76386517:-",".",".",".",".","gi|672083299|ref|XM_008772100.1|",1002,0,"PREDICTED: Rattus norvegicus zinc finger protein 516 (Zfp516), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam07666","MpPF26","M penetrans paralogue family 26. These proteins include those ascribed to M penetrans paralogue family 26 in.",".",".",".",".","."]
["ENSRNOG00000008706",143,12.03134342,442,28.43405368,0.423131487,-1.240822048,{"v":3.44412e-22,"d":"3.44E-22"},{"v":1.08397E-21,"d":"1.08E-21"},"down","yes","Tbx3","protein_coding","chr12:36881445-36893708:-","gi|31745146|ref|NP_853669.1|",3037,0,"T-box transcription factor TBX3 [Rattus norvegicus]","gi|672072989|ref|XM_006249416.2|",3317,0,"PREDICTED: Rattus norvegicus T-box 3 (Tbx3), transcript variant X2, mRNA","Q7TST9",1174,0,"T-box transcription factor TBX3",".",".",".",".","pfam00907","T-box","T-box. The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001501|skeletal system development;GO:0001568|blood vessel development;GO:0001701|in utero embryonic development;GO:0001708|cell fate specification;GO:0001947|heart looping;GO:0003007|heart morphogenesis;GO:0003151|outflow tract morphogenesis;GO:0003167|atrioventricular bundle cell differentiation;GO:0003205|cardiac chamber development;GO:0003272|endocardial cushion formation;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007417|central nervous system development;GO:0007569|cell aging;GO:0008284|positive regulation of cell proliferation;GO:0008595|anterior/posterior axis specification, embryo;GO:0009887|animal organ morphogenesis;GO:0010159|specification of animal organ position;GO:0019827|stem cell population maintenance;GO:0021761|limbic system development;GO:0030539|male genitalia development;GO:0030540|female genitalia development;GO:0030857|negative regulation of epithelial cell differentiation;GO:0030879|mammary gland development;GO:0032275|luteinizing hormone secretion;GO:0035050|embryonic heart tube development;GO:0035108|limb morphogenesis;GO:0035115|embryonic forelimb morphogenesis;GO:0035116|embryonic hindlimb morphogenesis;GO:0035136|forelimb morphogenesis;GO:0036302|atrioventricular canal development;GO:0042127|regulation of cell proliferation;GO:0042733|embryonic digit morphogenesis;GO:0043066|negative regulation of apoptotic process;GO:0045662|negative regulation of myoblast differentiation;GO:0045787|positive regulation of cell cycle;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046884|follicle-stimulating hormone secretion;GO:0048332|mesoderm morphogenesis;GO:0051145|smooth muscle cell differentiation;GO:0055007|cardiac muscle cell differentiation;GO:0060021|roof of mouth development;GO:0060317|cardiac epithelial to mesenchymal transition;GO:0060412|ventricular septum morphogenesis;GO:0060444|branching involved in mammary gland duct morphogenesis;GO:0060596|mammary placode formation;GO:0060923|cardiac muscle cell fate commitment;GO:0060931|sinoatrial node cell development;GO:0072105|ureteric peristalsis;GO:0090398|cellular senescence;GO:1905072|cardiac jelly development;GO:1905222|atrioventricular canal morphogenesis;GO:2000137|negative regulation of cell proliferation involved in heart morphogenesis;GO:2000648|positive regulation of stem cell proliferation;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0043565|sequence-specific DNA binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;GO:1990837|sequence-specific double-stranded DNA binding;","K10177","TBX3; T-box protein 3"]
["ENSRNOG00000017084",18,1.514434836,154,9.90688748,0.152866865,-2.709652365,{"v":3.66935e-22,"d":"3.67E-22"},{"v":1.15419E-21,"d":"1.15E-21"},"down","yes","Hsd11b2","protein_coding","chr19:33397656-33402899:+","gi|8393573|ref|NP_058777.1|",1800,0,"corticosteroid 11-beta-dehydrogenase isozyme 2 [Rattus norvegicus]","gi|402746764|ref|NM_017081.2|",1848,0,"Rattus norvegicus hydroxysteroid 11-beta dehydrogenase 2 (Hsd11b2), mRNA","P50233",697,0,"Corticosteroid 11-beta-dehydrogenase isozyme 2",".",".",".",".","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.","GO:0001666|response to hypoxia;GO:0002017|regulation of blood volume by renal aldosterone;GO:0007565|female pregnancy;GO:0008211|glucocorticoid metabolic process;GO:0009410|response to xenobiotic stimulus;GO:0032094|response to food;GO:0032868|response to insulin;GO:0048545|response to steroid hormone;GO:0051384|response to glucocorticoid;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005811|lipid droplet;GO:0043231|intracellular membrane-bounded organelle;","GO:0005496|steroid binding;GO:0016491|oxidoreductase activity;GO:0051287|NAD binding;","K00071","HSD11B2; corticosteroid 11-beta-dehydrogenase isozyme 2 [EC:1.1.1.-]"]
["ENSRNOG00000000479",146,12.28374922,447,28.75570587,0.427176063,-1.227097288,{"v":4.62528e-22,"d":"4.63E-22"},{"v":1.44569E-21,"d":"1.45E-21"},"down","yes","Kifc1","protein_coding","chr20:4999047-5017105:+","gi|54312052|ref|NP_001005878.1|",3052,0,"kinesin-like protein KIFC1 [Rattus norvegicus]","gi|54312051|ref|NM_001005878.1|",2217,0,"Rattus norvegicus kinesin family member C1 (Kifc1), mRNA","Q5XI63",1180,0,"Kinesin-like protein KIFC1","SPAC664.10",308,{"v":4e-91,"d":"4.00E-91"},"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0007018|microtubule-based movement;GO:0007080|mitotic metaphase plate congression;GO:0007283|spermatogenesis;GO:0051301|cell division;GO:0090307|mitotic spindle assembly;","GO:0005634|nucleus;GO:0005769|early endosome;GO:0005815|microtubule organizing center;GO:0005871|kinesin complex;GO:0005874|microtubule;GO:0072686|mitotic spindle;","GO:0003777|microtubule motor activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0008017|microtubule binding;GO:0016887|ATPase activity;","K10405","KIFC1; kinesin family member C1"]
["ENSRNOG00000037865",10,0.841352686,127,8.169965649,0.102981178,-3.279547417,{"v":5.47974e-22,"d":"5.48E-22"},{"v":1.70493e-21,"d":"1.70E-21"},"down","yes","Hormad2","protein_coding","chr14:79214998-79299910:-","gi|672076888|ref|XP_008768562.1|",1479,0,"PREDICTED: HORMA domain-containing protein 2 isoform X1 [Rattus norvegicus]","gi|672076887|ref|XM_008770340.1|",1114,0,"PREDICTED: Rattus norvegicus HORMA domain containing 2 (Hormad2), transcript variant X1, mRNA","Q5SQP1",548,0,"HORMA domain-containing protein 2",".",".",".",".","pfam02301","HORMA","HORMA domain. The HORMA (for Hop1p, Rev7p and MAD2) domain has been suggested to recognize chromatin states that result from DNA adducts, double stranded breaks or non-attachment to the spindle and acts as an adaptor that recruits other proteins. MAD2 is a spindle checkpoint protein which prevents progression of the cell cycle upon detection of a defect in mitotic spindle integrity.","GO:0051177|meiotic sister chromatid cohesion;GO:0051321|meiotic cell cycle;","GO:0000795|synaptonemal complex;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005694|chromosome;GO:0005813|centrosome;GO:0005829|cytosol;",".","K12778","HORMAD, HOP1; meiosis-specific protein"]
["ENSRNOG00000013834",12,1.009623224,133,8.555948279,0.118002493,-3.08311076,{"v":8.45867e-22,"d":"8.46E-22"},{"v":2.60941e-21,"d":"2.61E-21"},"down","yes","Svs5","protein_coding","chr3:152996146-152997756:+","gi|19424158|ref|NP_598200.1|",422,{"v":3E-49,"d":"3.00E-49"},"seminal vesicle secretory protein 5 precursor [Rattus norvegicus]","gi|672089715|ref|XM_008773873.1|",628,0,"PREDICTED: Rattus norvegicus seminal vesicle secretory protein 5 (LOC103694892), mRNA","P04812",165,{"v":4E-50,"d":"4.00E-50"},"Seminal vesicle secretory protein 5",".",".",".",".","pfam03038","Herpes_UL95","UL95 family. Members of this family, found in several herpesviruses, include EBV BGLF3 and other UL95 proteins (e.g. HCMV UL95, HVS-1 34, HSV6 U67). Their function is unknown.",".","GO:0005615|extracellular space;",".",".","."]
["ENSRNOG00000028441",208,17.50013588,564,36.28236714,0.482331702,-1.05190246,{"v":9.2768e-22,"d":"9.28E-22"},{"v":2.85856e-21,"d":"2.86E-21"},"down","yes","Zfp280b","protein_coding","chr20:12627106-12646683:-","gi|672089660|ref|XP_008772073.1|",2774,0,"PREDICTED: zinc finger protein 280B-like [Rattus norvegicus]","gi|672089661|ref|XM_008773852.1|",5087,0,"PREDICTED: Rattus norvegicus zinc finger protein 280B-like (LOC103690173), mRNA","Q86YH2",607,0,"Zinc finger protein 280B",".",".",".",".","pfam13836","DUF4195","Domain of unknown function (DUF4195). This family is found at the N-terminus of metazoan proteins that carry PHD-like zinc-finger domains. The function is not known.","GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0046872|metal ion binding;",".","."]
["ENSRNOG00000031167",51,4.290898701,240,15.43930516,0.277920454,-1.847256079,{"v":1.11033e-21,"d":"1.11E-21"},{"v":3.40981E-21,"d":"3.41E-21"},"down","yes","ENSRNOG00000031167","protein_coding","chr3:140599608-140628448:+","gi|672047421|ref|XP_008760530.1|",1186,{"v":2e-162,"d":"2.00E-162"},"PREDICTED: sulfiredoxin-1 isoform X1 [Rattus norvegicus]","gi|672047420|ref|XM_008762308.1|",767,0,"PREDICTED: Rattus norvegicus sulfiredoxin 1 (Srxn1), transcript variant X1, mRNA","Q9BYN0",179,{"v":9e-55,"d":"9.00E-55"},"Sulfiredoxin-1","SPBC106.02c",67.8,{"v":2e-13,"d":"2.00E-13"},"COG5119","pfam02195","ParBc","ParB-like nuclease domain.","GO:0006979|response to oxidative stress;GO:0098869|cellular oxidant detoxification;","GO:0005829|cytosol;","GO:0005524|ATP binding;GO:0016667|oxidoreductase activity, acting on a sulfur group of donors;","K12260","SRX1; sulfiredoxin [EC:1.8.98.2]"]
["ENSRNOG00000008596",48,4.038492895,232,14.92466166,0.270591923,-1.88580932,{"v":1.46097E-21,"d":"1.46E-21"},{"v":4.46144e-21,"d":"4.46E-21"},"down","yes","Ttll9","protein_coding","chr3:141429444-141475865:+","gi|62078835|ref|NP_001014073.1|",2506,0,"probable tubulin polyglutamylase TTLL9 [Rattus norvegicus]","gi|62078834|ref|NM_001014051.1|",1746,0,"Rattus norvegicus tubulin tyrosine ligase like 9 (Ttll9), mRNA","Q641W7",969,0,"Probable tubulin polyglutamylase TTLL9",".",".",".",".","pfam03133","TTL","Tubulin-tyrosine ligase family. Tubulins and microtubules are subjected to several post-translational modifications of which the reversible detyrosination/tyrosination of the carboxy-terminal end of most alpha-tubulins has been extensively analysed. This modification cycle involves a specific carboxypeptidase and the activity of the tubulin-tyrosine ligase (TTL). The true physiological function of TTL has so far not been established. Tubulin-tyrosine ligase (TTL) catalyses the ATP-dependent post-translational addition of a tyrosine to the carboxy terminal end of detyrosinated alpha-tubulin. In normally cycling cells, the tyrosinated form of tubulin predominates. However, in breast cancer cells, the detyrosinated form frequently predominates, with a correlation to tumor aggressiveness. On the other hand, 3-nitrotyrosine has been shown to be incorporated, by TTL, into the carboxy terminal end of detyrosinated alpha-tubulin. This reaction is not reversible by the carboxypeptidase enzyme. Cells cultured in 3-nitrotyrosine rich medium showed evidence of altered microtubule structure and function, including altered cell morphology, epithelial barrier dysfunction, and apoptosis. Bacterial homologs of TTL are predicted to form peptide tags. Some of these are fused to a 2-oxoglutarate Fe(II)-dependent dioxygenase domain.","GO:0000226|microtubule cytoskeleton organization;GO:0006464|cellular protein modification process;GO:0018095|protein polyglutamylation;GO:0030317|flagellated sperm motility;","GO:0005737|cytoplasm;GO:0005874|microtubule;GO:0005929|cilium;GO:0036064|ciliary basal body;","GO:0005524|ATP binding;GO:0015631|tubulin binding;GO:0070740|tubulin-glutamic acid ligase activity;","K16603","TTLL9; tubulin polyglutamylase TTLL9 [EC:6.3.2.61]"]
["ENSRNOG00000003178",196,16.49051265,539,34.67410618,0.475585804,-1.072222444,{"v":1.77833E-21,"d":"1.78E-21"},{"v":5.40936e-21,"d":"5.41E-21"},"down","yes","ENSRNOG00000003178","protein_coding","chrX:18349774-18351516:+","gi|61557433|ref|NP_001013268.1|",967,{"v":8e-125,"d":"8.00E-125"},"melanoma-associated antigen H1 [Rattus norvegicus]","gi|24395145|emb|AL840632.7|",1360,0,"Mouse DNA sequence from clone RP23-415B4 on chromosome X, complete sequence","Q5PPP4",377,{"v":3e-126,"d":"3.00E-126"},"Melanoma-associated antigen H1",".",".",".",".","pfam01454","MAGE","MAGE family. The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumors but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0048011|neurotrophin TRK receptor signaling pathway;","GO:0005634|nucleus;GO:0005737|cytoplasm;",".",".","."]
["ENSRNOG00000018477",186,15.64915997,520,33.45182786,0.467811805,-1.095999827,{"v":1.79974E-21,"d":"1.80E-21"},{"v":5.47142e-21,"d":"5.47E-21"},"down","yes","Otud4","protein_coding","chr19:28236713-28279815:-","gi|300794663|ref|NP_001178629.1|",5178,0,"OTU domain-containing protein 4 [Rattus norvegicus]","gi|300794662|ref|NM_001191700.1|",3193,0,"Rattus norvegicus OTU deubiquitinase 4 (Otud4), mRNA","B2RRE7",1920,0,"OTU domain-containing protein 4",".",".",".",".","pfam02338","OTU","OTU-like cysteine protease. This family is comprised of a group of predicted cysteine proteases, homologous to the Ovarian tumor (OTU) gene in Drosophila. Members include proteins from eukaryotes, viruses and pathogenic bacterium. The conserved cysteine and histidine, and possibly the aspartate, represent the catalytic residues in this putative group of proteases.","GO:0016579|protein deubiquitination;GO:0034122|negative regulation of toll-like receptor signaling pathway;GO:0070536|protein K63-linked deubiquitination;GO:0071108|protein K48-linked deubiquitination;GO:1901537|positive regulation of DNA demethylation;GO:1903093|regulation of protein K48-linked deubiquitination;GO:2000660|negative regulation of interleukin-1-mediated signaling pathway;","GO:0005829|cytosol;","GO:0004843|thiol-dependent ubiquitin-specific protease activity;GO:0060090|molecular adaptor activity;GO:0061578|Lys63-specific deubiquitinase activity;","K13718","OTUD4; OTU domain-containing protein 4 [EC:3.4.19.12]"]
["ENSRNOG00000066099",40,3.365410746,211,13.57372246,0.247935727,-2.011961919,{"v":2.2152e-21,"d":"2.22E-21"},{"v":6.70452e-21,"d":"6.70E-21"},"down","yes","ENSRNOG00000066099","lncRNA","chr1:53816738-53818753:-","gi|149028494|gb|EDL83879.1|",251,{"v":1e-23,"d":"1.00E-23"},"rCG22859 [Rattus norvegicus]","gi|31455626|gb|AC111648.6|",513,0,"Rattus norvegicus 2 BAC CH230-103N18 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam02093","Gag_p30","Gag P30 core shell protein. According to Swiss-Prot annotation this protein is the viral core shell protein. P30 is essential for viral assembly.",".",".",".",".","."]
["ENSRNOG00000052294",41,3.449546015,212,13.6380529,0.252935374,-1.983159275,{"v":4.19774e-21,"d":"4.20E-21"},{"v":1.26137E-20,"d":"1.26E-20"},"down","yes","Spint3","protein_coding","chr3:153294010-153296779:-","gi|392339673|ref|XP_002726340.2|",473,{"v":9e-58,"d":"9.00E-58"},"PREDICTED: kunitz-type protease inhibitor 3 [Rattus norvegicus]","gi|672017715|ref|XM_002726294.4|",572,0,"PREDICTED: Rattus norvegicus serine peptidase inhibitor, Kunitz type, 3 (Spint3), mRNA","P49223",74.3,{"v":7e-16,"d":"7.00E-16"},"Kunitz-type protease inhibitor 3",".",".",".",".","pfam00014","Kunitz_BPTI","Kunitz/Bovine pancreatic trypsin inhibitor domain. Indicative of a protease inhibitor, usually a serine protease inhibitor. Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure. Certain family members are similar to the tick anticoagulant peptide (TAP). This is a highly selective inhibitor of factor Xa in the blood coagulation pathways. TAP molecules are highly dipolar, and are arranged to form a twisted two- stranded antiparallel beta-sheet followed by an alpha helix.","GO:0010951|negative regulation of endopeptidase activity;",".",".","K23422","SPINT3; Kunitz-type protease inhibitor 3"]
["ENSRNOG00000050072",69,5.805333537,278,17.88386182,0.324612972,-1.623207441,{"v":5.20216E-21,"d":"5.20E-21"},{"v":1.55803e-20,"d":"1.56E-20"},"down","yes","Jmjd7","protein_coding","chr3:106998477-107004538:+","gi|167900431|ref|NP_001108128.1|",1683,0,"jmjC domain-containing protein 7 [Rattus norvegicus]","gi|167900430|ref|NM_001114656.1|",1335,0,"Rattus norvegicus jumonji domain containing 7 (Jmjd7), mRNA","P0C872",639,0,"JmjC domain-containing protein 7",".",".",".",".","pfam13621","Cupin_8","Cupin-like domain. This cupin like domain shares similarity to the JmjC domain.","GO:0006508|proteolysis;GO:0018126|protein hydroxylation;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0004175|endopeptidase activity;GO:0004177|aminopeptidase activity;GO:0004497|monooxygenase activity;GO:0016706|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0035064|methylated histone binding;","K19219","JMJD7; peptidyl-lysine (3S)-dioxygenase / protease [EC:1.14.11.63 3.4.-.-]"]
["ENSRNOG00000029370",195,16.40637739,532,34.22379311,0.479385126,-1.060742947,{"v":7.07432E-21,"d":"7.07E-21"},{"v":2.10945E-20,"d":"2.11E-20"},"down","yes","Abhd3","protein_coding","chr18:1720718-1803428:-","gi|157820211|ref|NP_001099632.1|",2088,0,"abhydrolase domain-containing protein 3 [Rattus norvegicus]","gi|157820210|ref|NM_001106162.1|",1912,0,"Rattus norvegicus abhydrolase domain containing 3 (Abhd3), mRNA","Q91ZH7",786,0,"Phospholipase ABHD3","PA0368",130,{"v":1e-31,"d":"1.00E-31"},"COG0429","pfam06701","MIB_HERC2","Mib_herc2. Named \"mib/herc2 domain\" in. Usually the protein also contains an E3 ligase domain (either Ring or Hect).","GO:0008150|biological_process;GO:0044255|cellular lipid metabolic process;GO:0046470|phosphatidylcholine metabolic process;GO:0051792|medium-chain fatty acid biosynthetic process;GO:0051793|medium-chain fatty acid catabolic process;","GO:0005575|cellular_component;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0004623|phospholipase A2 activity;GO:0008126|acetylesterase activity;GO:0008970|phospholipase A1 activity;GO:0034338|short-chain carboxylesterase activity;GO:0047372|acylglycerol lipase activity;","K13696","ABHD1_3; abhydrolase domain-containing protein 1/3"]
["ENSRNOG00000002980",135,11.35826127,416,26.76146228,0.424426033,-1.236414946,{"v":7.18667e-21,"d":"7.19E-21"},{"v":2.14178e-20,"d":"2.14E-20"},"down","yes","Tsr1","protein_coding","chr10:59760409-59771864:+","gi|293340242|ref|XP_002724564.1|",3387,0,"PREDICTED: pre-rRNA-processing protein TSR1 homolog [Rattus norvegicus]","gi|392331809|ref|XM_002724518.2|",2197,0,"PREDICTED: Rattus norvegicus TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) (Tsr1), mRNA","Q5SWD9",1255,0,"Pre-rRNA-processing protein TSR1 homolog","SPAC23H4.15",243,{"v":7e-82,"d":"7.00E-82"},"COG5177","pfam04950","DUF663","Protein of unknown function (DUF663). This family contains several uncharacterized eukaryotic proteins.","GO:0000462|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000479|endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);","GO:0005730|nucleolus;GO:0030688|preribosome, small subunit precursor;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0034511|U3 snoRNA binding;","K14799","TSR1; pre-rRNA-processing protein TSR1"]
["ENSRNOG00000028908",117,9.843826432,377,24.2525752,0.405887884,-1.300846819,{"v":1.67007E-20,"d":"1.67E-20"},{"v":4.89413e-20,"d":"4.89E-20"},"down","yes","Eppin","protein_coding","chr3:153312396-153319310:-","gi|157822521|ref|NP_001102927.1|",594,{"v":1e-74,"d":"1.00E-74"},"eppin precursor [Rattus norvegicus]","gi|157822520|ref|NM_001109457.1|",731,0,"Rattus norvegicus epididymal peptidase inhibitor (Eppin), mRNA","D4A2Z2",233,{"v":5e-76,"d":"5.00E-76"},"Eppin",".",".",".",".","pfam00014","Kunitz_BPTI","Kunitz/Bovine pancreatic trypsin inhibitor domain. Indicative of a protease inhibitor, usually a serine protease inhibitor. Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure. Certain family members are similar to the tick anticoagulant peptide (TAP). This is a highly selective inhibitor of factor Xa in the blood coagulation pathways. TAP molecules are highly dipolar, and are arranged to form a twisted two- stranded antiparallel beta-sheet followed by an alpha helix.","GO:0010466|negative regulation of peptidase activity;GO:0010951|negative regulation of endopeptidase activity;GO:0042742|defense response to bacterium;GO:0090281|negative regulation of calcium ion import;GO:1901318|negative regulation of flagellated sperm motility;","GO:0001669|acrosomal vesicle;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0009986|cell surface;GO:0032991|protein-containing complex;","GO:0004867|serine-type endopeptidase inhibitor activity;","K23622","EPPIN; eppin"]
["ENSRNOG00000069152",121,10.18036751,385,24.7672187,0.411042016,-1.282642224,{"v":1.73521e-20,"d":"1.74E-20"},{"v":5.08228e-20,"d":"5.08E-20"},"down","yes","ENSRNOG00000069152","lncRNA","chr12:9352241-9353979:-","gi|149038339|gb|EDL92699.1|",194,{"v":5E-15,"d":"5.00E-15"},"rCG63222 [Rattus norvegicus]","gi|672026501|ref|XR_339408.2|",537,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102554162 (LOC102554162), ncRNA",".",".",".",".",".",".",".",".","pfam00509","Hemagglutinin","Haemagglutinin. Hemagglutinin from influenza virus causes membrane fusion of the viral membrane with the host membrane. Fusion occurs after the host cell internalises the virus by endocytosis. The drop of pH causes release of a hydrophobic fusion peptide and a large conformational change leading to membrane fusion.",".",".",".",".","."]
["ENSRNOG00000006911",160,13.46164298,462,29.72066244,0.452938861,-1.142611772,{"v":1.76219e-20,"d":"1.76E-20"},{"v":5.15852e-20,"d":"5.16E-20"},"down","yes","Sptb","protein_coding","chr6:95310326-95437118:-","gi|564356403|ref|XP_006240306.1|",11838,0,"PREDICTED: spectrin beta chain, erythrocytic isoform X2 [Rattus norvegicus]","gi|672056538|ref|XM_006240244.2|",9842,0,"PREDICTED: Rattus norvegicus spectrin, beta, erythrocytic (Sptb), transcript variant X4, mRNA","P15508",4042,0,"Spectrin beta chain, erythrocytic","SPAC15A10.08",261,{"v":3e-72,"d":"3.00E-72"},"COG5069","pfam00307","CH","Calponin homology (CH) domain. The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.","GO:0006779|porphyrin-containing compound biosynthetic process;GO:0007009|plasma membrane organization;GO:0007010|cytoskeleton organization;GO:0008150|biological_process;GO:0030036|actin cytoskeleton organization;GO:0030097|hemopoiesis;GO:0051693|actin filament capping;","GO:0005575|cellular_component;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0008091|spectrin;GO:0009986|cell surface;GO:0014731|spectrin-associated cytoskeleton;GO:0016020|membrane;GO:0030054|cell junction;GO:0030863|cortical cytoskeleton;GO:0030864|cortical actin cytoskeleton;GO:0032991|protein-containing complex;GO:0042995|cell projection;","GO:0003674|molecular_function;GO:0003779|actin binding;GO:0005200|structural constituent of cytoskeleton;GO:0005543|phospholipid binding;GO:0030506|ankyrin binding;GO:0051015|actin filament binding;","K06115","SPTB; spectrin beta"]
["ENSRNOG00000018310",30,2.524058059,180,11.57947887,0.217976827,-2.197753326,{"v":1.76748e-20,"d":"1.77E-20"},{"v":5.16846e-20,"d":"5.17E-20"},"down","yes","Eno4","protein_coding","chr1:258096432-258128984:+","gi|564334485|ref|XP_006231731.1|",2849,0,"PREDICTED: enolase-like protein ENO4 isoform X1 [Rattus norvegicus]","gi|672040743|ref|XM_006231669.2|",3145,0,"PREDICTED: Rattus norvegicus enolase family member 4 (Eno4), transcript variant X1, mRNA","Q8C042",988,0,"Enolase 4","FN1764",100,{"v":2e-21,"d":"2.00E-21"},"COG0148","pfam00113","Enolase_C","Enolase, C-terminal TIM barrel domain.","GO:0006096|glycolytic process;GO:0008150|biological_process;GO:0030317|flagellated sperm motility;GO:0044782|cilium organization;","GO:0000015|phosphopyruvate hydratase complex;GO:0005575|cellular_component;GO:0097228|sperm principal piece;","GO:0000287|magnesium ion binding;GO:0003674|molecular_function;GO:0004634|phosphopyruvate hydratase activity;","K01689","ENO, eno; enolase [EC:4.2.1.11]"]
["ENSRNOG00000047005",65,5.468792462,264,16.98323568,0.322011221,-1.634817132,{"v":3.1969E-20,"d":"3.20E-20"},{"v":9.25883e-20,"d":"9.26E-20"},"down","yes","Kcnk5","protein_coding","chr15:4122442-4164718:+","gi|87252701|ref|NP_001034605.1|",2418,0,"potassium channel subfamily K member 5 [Rattus norvegicus]","gi|121583860|ref|NM_001039516.2|",3464,0,"Rattus norvegicus potassium two pore domain channel subfamily K member 5 (Kcnk5), mRNA","O95279",815,0,"Potassium channel subfamily K member 5","MA2218",50.8,3e-06,"COG1226","pfam07885","Ion_trans_2","Ion channel. This family includes the two membrane helix type ion channels found in bacteria.","GO:0030322|stabilization of membrane potential;GO:0060075|regulation of resting membrane potential;GO:0071805|potassium ion transmembrane transport;GO:0097623|potassium ion export across plasma membrane;GO:1990573|potassium ion import across plasma membrane;","GO:0005887|integral component of plasma membrane;","GO:0005249|voltage-gated potassium channel activity;GO:0005267|potassium channel activity;GO:0022841|potassium ion leak channel activity;","K04916","KCNK5, K2P5.1; potassium channel subfamily K member 5"]
["ENSRNOG00000008489",34,2.860599134,189,12.15845282,0.235276575,-2.087570408,{"v":3.50984e-20,"d":"3.51E-20"},{"v":1.01544E-19,"d":"1.02E-19"},"down","yes","Ppih","protein_coding","chr5:132906328-132924267:-","gi|148698503|gb|EDL30450.1|",946,{"v":1e-124,"d":"1.00E-124"},"mCG4207, isoform CRA_b, partial [Mus musculus]","gi|672019868|ref|XM_006225500.2|",1189,0,"PREDICTED: Rattus norvegicus peptidylprolyl isomerase H (cyclophilin H) (Ppih), transcript variant X3, mRNA","O43447",364,{"v":1e-124,"d":"1.00E-124"},"Peptidyl-prolyl cis-trans isomerase H","SPBC1709.04c",219,{"v":1e-68,"d":"1.00E-68"},"COG0652","pfam00160","Pro_isomerase","Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD. The peptidyl-prolyl cis-trans isomerases, also known as cyclophilins, share this domain of about 109 amino acids. Cyclophilins have been found in all organisms studied so far and catalyse peptidyl-prolyl isomerization during which the peptide bond preceding proline (the peptidyl-prolyl bond) is stabilized in the cis conformation. Mammalian cyclophilin A (CypA) is a major cellular target for the immunosuppressive drug cyclosporin A (CsA). Other roles for cyclophilins may include chaperone and cell signalling function.","GO:0000413|protein peptidyl-prolyl isomerization;GO:0006457|protein folding;GO:0008150|biological_process;GO:0045070|positive regulation of viral genome replication;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0016607|nuclear speck;GO:0043231|intracellular membrane-bounded organelle;GO:0046540|U4/U6 x U5 tri-snRNP complex;GO:0071001|U4/U6 snRNP;","GO:0003674|molecular_function;GO:0003755|peptidyl-prolyl cis-trans isomerase activity;GO:0016018|cyclosporin A binding;GO:0043021|ribonucleoprotein complex binding;","K09567","PPIH, CYPH; peptidyl-prolyl isomerase H (cyclophilin H) [EC:5.2.1.8]"]
["ENSRNOG00000027770",36,3.028869671,194,12.48010501,0.242695848,-2.042778666,{"v":3.78193e-20,"d":"3.78E-20"},{"v":1.09242E-19,"d":"1.09E-19"},"down","yes","Trpm3","protein_coding","chr1:219672892-220560717:+","gi|54144620|ref|NP_796315.2|",6689,0,"transient receptor potential cation channel subfamily M member 3 isoform f [Mus musculus]","gi|133892589|ref|NM_177341.4|",4542,0,"Mus musculus transient receptor potential cation channel, subfamily M, member 3 (Trpm3), transcript variant 6, mRNA","Q9HCF6",2498,0,"Transient receptor potential cation channel subfamily M member 3",".",".",".",".","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0006812|cation transport;GO:0016048|detection of temperature stimulus;GO:0050951|sensory perception of temperature stimulus;GO:0051262|protein tetramerization;GO:0098655|cation transmembrane transport;","GO:0005887|integral component of plasma membrane;","GO:0005227|calcium activated cation channel activity;GO:0005261|cation channel activity;","K04978","TRPM3; transient receptor potential cation channel subfamily M member 3"]
["ENSRNOG00000017545",170,14.30299567,478,30.74994945,0.465138835,-1.104266697,{"v":4.34068e-20,"d":"4.34E-20"},{"v":1.24917e-19,"d":"1.25E-19"},"down","yes","Mrs2","protein_coding","chr17:40063962-40081887:+","gi|71051779|gb|AAH98916.1|",2232,0,"Mrs2 protein [Rattus norvegicus]","gi|672081844|ref|XM_006253937.2|",2303,0,"PREDICTED: Rattus norvegicus MRS2 magnesium transporter (Mrs2), transcript variant X1, mRNA","Q9ET09",754,0,"Magnesium transporter MRS2 homolog, mitochondrial",".",".",".",".","pfam01544","CorA","CorA-like Mg2+ transporter protein. The CorA transport system is the primary Mg2+ influx system of Salmonella typhimurium and Escherichia coli. CorA is virtually ubiquitous in the Bacteria and Archaea. There are also eukaryotic relatives of this protein. The family includes the MRS2 protein from yeast that is thought to be an RNA splicing protein. However its membership of this family suggests that its effect on splicing is due to altered magnesium levels in the cell.","GO:0006089|lactate metabolic process;GO:0015693|magnesium ion transport;GO:0045016|mitochondrial magnesium ion transmembrane transport;","GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0016021|integral component of membrane;","GO:0015095|magnesium ion transmembrane transporter activity;","K16075","MRS2, MFM1; magnesium transporter"]
["ENSRNOG00000016258",144,12.11547869,427,27.4690971,0.441058497,-1.180958083,{"v":5.39604e-20,"d":"5.40E-20"},{"v":1.54879e-19,"d":"1.55E-19"},"down","yes","Zfp516","protein_coding","chr18:76302096-76385269:+","gi|672083300|ref|XP_008770322.1|",5240,0,"PREDICTED: zinc finger protein 516 isoform X3 [Rattus norvegicus]","gi|672083301|ref|XR_596965.1|",3240,0,"PREDICTED: Rattus norvegicus zinc finger protein 516 (Zfp516), transcript variant X4, misc_RNA","Q7TSH3",1859,0,"Zinc finger protein 516",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0009409|response to cold;GO:0045893|positive regulation of transcription, DNA-templated;GO:0050873|brown fat cell differentiation;GO:0060612|adipose tissue development;GO:0120162|positive regulation of cold-induced thermogenesis;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987|proximal promoter sequence-specific DNA binding;","K22411","ZNF516; zinc finger protein 516"]
["ENSRNOG00000038375",76,6.394280417,287,18.46283576,0.346332519,-1.529770239,{"v":5.53862e-20,"d":"5.54E-20"},{"v":1.58637e-19,"d":"1.59E-19"},"down","yes","AABR07026311.1","protein_coding","chr16:66654287-66655279:+","gi|958714273|ref|XP_014701553.1|",610,{"v":9e-76,"d":"9.00E-76"},"PREDICTED: histone H2A.Z [Equus asinus]","gi|298903825|emb|FQ213837.1|",962,0,"Rattus norvegicus TL0AAA45YF14 mRNA sequence","Q6YNC8",239,{"v":3e-77,"d":"3.00E-77"},"Histone H2A.Z","SPBC11B10.10c",167,{"v":3E-49,"d":"3.00E-49"},"COG5262","pfam00125","Histone","Core histone H2A/H2B/H3/H4.",".",".",".",".","."]
["ENSRNOG00000016525",140,11.77893761,419,26.9544536,0.436994116,-1.194314242,{"v":5.64163e-20,"d":"5.64E-20"},{"v":1.61418e-19,"d":"1.61E-19"},"down","yes","Susd3","protein_coding","chr17:15400845-15417044:+","gi|157823895|ref|NP_001100811.1|",1127,{"v":2E-150,"d":"2.00E-150"},"sushi domain-containing protein 3 [Rattus norvegicus]","gi|157823894|ref|NM_001107341.1|",1279,0,"Rattus norvegicus sushi domain containing 3 (Susd3), mRNA","Q9D176",377,{"v":9e-128,"d":"9.00E-128"},"Sushi domain-containing protein 3",".",".",".",".","pfam00084","Sushi","Sushi domain (SCR repeat).",".","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;",".","K23821","SUSD3; sushi domain-containing protein 3"]
["ENSRNOG00000010100",139,11.69480234,417,26.82579272,0.435953653,-1.197753326,{"v":5.69586e-20,"d":"5.70E-20"},{"v":1.62884E-19,"d":"1.63E-19"},"down","yes","Tyw5","protein_coding","chr9:58961106-58979188:-","gi|281427194|ref|NP_001163944.1|",1687,0,"tRNA wybutosine-synthesizing protein 5 [Rattus norvegicus]","gi|281427193|ref|NM_001170473.1|",1472,0,"Rattus norvegicus tRNA-yW synthesizing protein 5 (Tyw5), transcript variant 1, mRNA","A2RSX7",636,0,"tRNA wybutosine-synthesizing protein 5",".",".",".",".","pfam13621","Cupin_8","Cupin-like domain. This cupin like domain shares similarity to the JmjC domain.","GO:0031591|wybutosine biosynthetic process;",".","GO:0000049|tRNA binding;GO:0005506|iron ion binding;GO:0016706|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0042803|protein homodimerization activity;GO:0102524|tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity;","K18066","TYW5; tRNA wybutosine-synthesizing protein 5 [EC:1.14.11.42]"]
["ENSRNOG00000006060",206,17.33186534,544,34.99575837,0.495256172,-1.013753139,{"v":6.72704e-20,"d":"6.73E-20"},{"v":1.91568E-19,"d":"1.92E-19"},"down","yes","Matn2","protein_coding","chr7:65494834-65645113:+","gi|672059136|ref|XP_216941.7|",4814,0,"PREDICTED: matrilin-2 isoform X2, partial [Rattus norvegicus]","gi|672059135|ref|XM_216941.8|",3639,0,"PREDICTED: Rattus norvegicus matrilin 2 (Matn2), transcript variant X2, partial mRNA","O08746",1794,0,"Matrilin-2",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0001764|neuron migration;GO:0007411|axon guidance;GO:0008347|glial cell migration;GO:0031104|dendrite regeneration;GO:0031175|neuron projection development;GO:0048678|response to axon injury;","GO:0005604|basement membrane;GO:0031012|extracellular matrix;GO:0062023|collagen-containing extracellular matrix;","GO:0005509|calcium ion binding;","K19467","MATN; matrilin"]
["ENSRNOG00000007426",91,7.656309447,317,20.3927489,0.375442736,-1.413335215,{"v":1.20725e-19,"d":"1.21E-19"},{"v":3.40056e-19,"d":"3.40E-19"},"down","yes","Tmem64","protein_coding","chr5:28698918-28745330:+","gi|392340363|ref|XP_003754051.1|",1291,{"v":3e-172,"d":"3.00E-172"},"PREDICTED: transmembrane protein 64 [Rattus norvegicus]","gi|672019166|ref|XM_003754003.3|",1375,0,"PREDICTED: Rattus norvegicus transmembrane protein 64 (Tmem64), mRNA","Q3U145",466,{"v":1e-159,"d":"1.00E-159"},"Transmembrane protein 64","slr0305",63.5,{"v":1E-10,"d":"1.00E-10"},"COG0398","pfam09335","SNARE_assoc","SNARE associated Golgi protein. This is a family of SNARE associated Golgi proteins. The yeast member of this family localizes with the t-SNARE Tlg2.","GO:0043462|regulation of ATPase activity;GO:0045600|positive regulation of fat cell differentiation;GO:0045668|negative regulation of osteoblast differentiation;GO:0045672|positive regulation of osteoclast differentiation;GO:0045780|positive regulation of bone resorption;GO:0051480|regulation of cytosolic calcium ion concentration;GO:0090090|negative regulation of canonical Wnt signaling pathway;","GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000017424",69,5.805333537,269,17.30488787,0.335473629,-1.575728731,{"v":1.36427e-19,"d":"1.36E-19"},{"v":3.82701e-19,"d":"3.83E-19"},"down","yes","Chrna2","protein_coding","chr15:40342317-40358601:+","gi|672078229|ref|XP_008768957.1|",2690,0,"PREDICTED: neuronal acetylcholine receptor subunit alpha-2 isoform X1 [Rattus norvegicus]","gi|19173791|ref|NM_133420.1|",1931,0,"Rattus norvegicus cholinergic receptor nicotinic alpha 2 subunit (Chrna2), mRNA","P12389",990,0,"Neuronal acetylcholine receptor subunit alpha-2",".",".",".",".","pfam02931","Neur_chan_LBD","Neurotransmitter-gated ion-channel ligand binding domain. This family is the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.","GO:0007165|signal transduction;GO:0007268|chemical synaptic transmission;GO:0007271|synaptic transmission, cholinergic;GO:0034220|ion transmembrane transport;GO:0035094|response to nicotine;GO:0042391|regulation of membrane potential;GO:0050877|nervous system process;GO:0060079|excitatory postsynaptic potential;","GO:0005887|integral component of plasma membrane;GO:0005892|acetylcholine-gated channel complex;GO:0016020|membrane;GO:0032991|protein-containing complex;GO:0043005|neuron projection;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0071944|cell periphery;","GO:0015464|acetylcholine receptor activity;GO:0022848|acetylcholine-gated cation-selective channel activity;GO:0030594|neurotransmitter receptor activity;","K04804","CHRNA2; nicotinic acetylcholine receptor alpha-2"]
["ENSRNOG00000010608",186,15.64915997,504,32.42254085,0.482662973,-1.050911938,{"v":1.38445e-19,"d":"1.38E-19"},{"v":3.88163e-19,"d":"3.88E-19"},"down","yes","Cep162","protein_coding","chr8:88149726-88206830:-","gi|456367253|ref|NP_001263989.1|",6890,0,"centrosomal protein of 162 kDa [Rattus norvegicus]","gi|672062689|ref|XM_006243475.2|",5499,0,"PREDICTED: Rattus norvegicus centrosomal protein 162 (Cep162), transcript variant X1, mRNA","Q4KLH6",2633,0,"Centrosomal protein of 162 kDa",".",".",".",".","pfam10174","Cast","RIM-binding protein of the cytomatrix active zone. This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.","GO:0060271|cilium assembly;","GO:0005634|nucleus;GO:0005813|centrosome;GO:0005814|centriole;GO:0005819|spindle;GO:0005879|axonemal microtubule;",".","K16809","CEP162; centrosomal protein CEP162"]
["ENSRNOG00000052157",35,2.944734403,187,12.02979194,0.244786811,-2.030402268,{"v":2.44406e-19,"d":"2.44E-19"},{"v":6.7861e-19,"d":"6.79E-19"},"down","yes","Nav3","protein_coding","chr7:45054296-45840698:-","gi|124486648|ref|NP_001074504.1|",9485,0,"neuron navigator 3 [Mus musculus]","gi|300796330|ref|NM_001191782.1|",6641,0,"Rattus norvegicus neuron navigator 3 (Nav3), mRNA","Q80TN7",3638,0,"Neuron navigator 3","ECU09g0290",71.6,{"v":2e-11,"d":"2.00E-11"},"COG5069","pfam00307","CH","Calponin homology (CH) domain. The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.","GO:0007026|negative regulation of microtubule depolymerization;GO:0022008|neurogenesis;GO:0030336|negative regulation of cell migration;GO:0031116|positive regulation of microtubule polymerization;GO:0032703|negative regulation of interleukin-2 production;","GO:0005634|nucleus;GO:0005635|nuclear envelope;GO:1990752|microtubule end;","GO:0005524|ATP binding;GO:0008017|microtubule binding;","K23919","NAV3; neuron navigator 3"]
["ENSRNOG00000007290",111,9.33901482,355,22.83730556,0.408936807,-1.290050173,{"v":3.59858E-19,"d":"3.60E-19"},{"v":9.91584e-19,"d":"9.92E-19"},"down","yes","Atp1a2","protein_coding","chr13:84729601-84754544:-","gi|6978545|ref|NP_036637.1|",5296,0,"sodium/potassium-transporting ATPase subunit alpha-2 precursor [Rattus norvegicus]","gi|292494900|ref|NM_012505.2|",5128,0,"Rattus norvegicus ATPase Na+/K+ transporting subunit alpha 2 (Atp1a2), mRNA","P06686",2029,0,"Sodium/potassium-transporting ATPase subunit alpha-2","MA4378",656,0,"COG0474","pfam00122","E1-E2_ATPase","E1-E2 ATPase.","GO:0001504|neurotransmitter uptake;GO:0001662|behavioral fear response;GO:0002026|regulation of the force of heart contraction;GO:0002087|regulation of respiratory gaseous exchange by neurological system process;GO:0006813|potassium ion transport;GO:0006814|sodium ion transport;GO:0006883|cellular sodium ion homeostasis;GO:0006937|regulation of muscle contraction;GO:0006940|regulation of smooth muscle contraction;GO:0006942|regulation of striated muscle contraction;GO:0008217|regulation of blood pressure;GO:0008344|adult locomotory behavior;GO:0008542|visual learning;GO:0010248|establishment or maintenance of transmembrane electrochemical gradient;GO:0010882|regulation of cardiac muscle contraction by calcium ion signaling;GO:0010996|response to auditory stimulus;GO:0015988|energy coupled proton transmembrane transport, against electrochemical gradient;GO:0019229|regulation of vasoconstriction;GO:0021764|amygdala development;GO:0021989|olfactory cortex development;GO:0030007|cellular potassium ion homeostasis;GO:0035094|response to nicotine;GO:0035641|locomotory exploration behavior;GO:0035725|sodium ion transmembrane transport;GO:0036376|sodium ion export across plasma membrane;GO:0040011|locomotion;GO:0045822|negative regulation of heart contraction;GO:0045988|negative regulation of striated muscle contraction;GO:0046034|ATP metabolic process;GO:0051481|negative regulation of cytosolic calcium ion concentration;GO:0055119|relaxation of cardiac muscle;GO:0060048|cardiac muscle contraction;GO:0071260|cellular response to mechanical stimulus;GO:0071383|cellular response to steroid hormone stimulus;GO:0071805|potassium ion transmembrane transport;GO:0086004|regulation of cardiac muscle cell contraction;GO:0098655|cation transmembrane transport;GO:1902600|proton transmembrane transport;GO:1903170|negative regulation of calcium ion transmembrane transport;GO:1903280|negative regulation of calcium:sodium antiporter activity;GO:1903416|response to glycoside;GO:1990573|potassium ion import across plasma membrane;","GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005886|plasma membrane;GO:0005890|sodium:potassium-exchanging ATPase complex;GO:0005901|caveola;GO:0014704|intercalated disc;GO:0016020|membrane;GO:0030315|T-tubule;GO:0031090|organelle membrane;GO:0042383|sarcolemma;GO:0042995|cell projection;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043197|dendritic spine;GO:0045202|synapse;GO:0070382|exocytic vesicle;","GO:0005391|sodium:potassium-exchanging ATPase activity;GO:0005496|steroid binding;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0016887|ATPase activity;GO:0019829|cation-transporting ATPase activity;GO:0030955|potassium ion binding;GO:0031402|sodium ion binding;GO:0046982|protein heterodimerization activity;GO:0051087|chaperone binding;GO:1990239|steroid hormone binding;","K01539","ATP1A; sodium/potassium-transporting ATPase subunit alpha [EC:7.2.2.13]"]
["ENSRNOG00000023812",70,5.889468805,268,17.24055743,0.341605475,-1.549596999,{"v":4.30978e-19,"d":"4.31E-19"},{"v":1.18217E-18,"d":"1.18E-18"},"down","yes","Raver2","protein_coding","chr5:115701326-115778792:+","gi|564351842|ref|XP_006238513.1|",3053,0,"PREDICTED: ribonucleoprotein PTB-binding 2 isoform X1 [Rattus norvegicus]","gi|672053214|ref|XM_006238451.2|",2452,0,"PREDICTED: Rattus norvegicus ribonucleoprotein, PTB-binding 2 (Raver2), transcript variant X1, mRNA","Q7TPD6",1137,0,"Ribonucleoprotein PTB-binding 2",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0000381|regulation of alternative mRNA splicing, via spliceosome;","GO:0005634|nucleus;","GO:0003729|mRNA binding;","K25000","RAVER2; ribonucleoprotein PTB-binding 2"]
["ENSRNOG00000063592",103,8.665932671,338,21.74368811,0.398549346,-1.327169734,{"v":4.4408e-19,"d":"4.44E-19"},{"v":1.21627E-18,"d":"1.22E-18"},"down","yes","Lyve1","pseudogene","chr1:164962872-164976309:-","gi|61889129|ref|NP_058961.4|",1518,0,"3 beta-hydroxysteroid dehydrogenase/Delta 5-->gi|157820637|ref|NP_001099756.1| lymphatic vessel endothelial hyaluronic acid receptor 1 [Rattus norvegicus]","gi|157820636|ref|NM_001106286.1|",2982,0,"Rattus norvegicus lymphatic vessel endothelial hyaluronan receptor 1 (Lyve1), mRNA","Q8BHC0",449,{"v":1e-147,"d":"1.00E-147"},"Lymphatic vessel endothelial hyaluronic acid receptor 1",".",".",".",".","pfam00193","Xlink","Extracellular link domain.",".",".",".",".","."]
["ENSRNOG00000004753",53,4.459169238,229,14.73167034,0.302692711,-1.724074159,{"v":5.13382e-19,"d":"5.13E-19"},{"v":1.40115e-18,"d":"1.40E-18"},"down","yes","Napb","protein_coding","chr3:136133428-136179345:-","gi|29789104|ref|NP_062606.1|",1550,0,"beta-soluble NSF attachment protein [Mus musculus]","gi|672047296|ref|XM_008762275.1|",3097,0,"PREDICTED: Rattus norvegicus N-ethylmaleimide-sensitive factor attachment protein, beta (Napb), transcript variant X1, mRNA","P28663",601,0,"Beta-soluble NSF attachment protein",".",".",".",".","pfam14938","SNAP","Soluble NSF attachment protein, SNAP. The soluble NSF attachment protein (SNAP) proteins are involved in vesicular transport between the endoplasmic reticulum and Golgi apparatus. They act as adaptors between SNARE (integral membrane SNAP receptor) proteins and NSF (N-ethylmaleimide-sensitive factor). They are structurally similar to TPR repeats.","GO:0002090|regulation of receptor internalization;GO:0006886|intracellular protein transport;GO:0008150|biological_process;GO:0010807|regulation of synaptic vesicle priming;GO:0032984|protein-containing complex disassembly;GO:0035249|synaptic transmission, glutamatergic;GO:0035494|SNARE complex disassembly;GO:0043462|regulation of ATPase activity;","GO:0005575|cellular_component;GO:0005774|vacuolar membrane;GO:0031201|SNARE complex;GO:0070044|synaptobrevin 2-SNAP-25-syntaxin-1a complex;GO:0098793|presynapse;GO:0098794|postsynapse;GO:0098978|glutamatergic synapse;","GO:0000149|SNARE binding;GO:0003674|molecular_function;GO:0005483|soluble NSF attachment protein activity;GO:0019905|syntaxin binding;",".","."]
["ENSRNOG00000006019",106,8.918338477,343,22.0653403,0.404178606,-1.306935137,{"v":6.38087e-19,"d":"6.38E-19"},{"v":1.73541e-18,"d":"1.74E-18"},"down","yes","G0s2","protein_coding","chr13:104806156-104807451:-","gi|57526884|ref|NP_001009632.1|",427,{"v":3e-48,"d":"3.00E-48"},"G0/G1 switch protein 2 [Rattus norvegicus]","gi|57526883|ref|NM_001009632.1|",729,0,"Rattus norvegicus G0/G1switch 2 (G0s2), mRNA","Q5M840",169,{"v":9e-50,"d":"9.00E-50"},"G0/G1 switch protein 2",".",".",".",".","pfam15103","G0-G1_switch_2","G0/G1 switch protein 2. This family of proteins regulate apoptosis by binding to Bcl-2 and preventing the formation of the anti-apoptotic BAX-BCL2 heterodimers.","GO:0097191|extrinsic apoptotic signaling pathway;GO:0120162|positive regulation of cold-induced thermogenesis;GO:2001238|positive regulation of extrinsic apoptotic signaling pathway;","GO:0005739|mitochondrion;",".",".","."]
["ENSRNOG00000014481",33,2.776463865,179,11.51514844,0.241114032,-2.052212483,{"v":8.16192e-19,"d":"8.16E-19"},{"v":2.20986E-18,"d":"2.21E-18"},"down","yes","Adtrp","protein_coding","chr17:22930740-22993826:+","gi|62079023|ref|NP_001014166.1|",1048,{"v":6e-140,"d":"6.00E-140"},"androgen-dependent TFPI-regulating protein [Rattus norvegicus]","gi|62079022|ref|NM_001014144.1|",1096,0,"Rattus norvegicus androgen-dependent TFPI-regulating protein (Adtrp), mRNA","Q5M828",408,{"v":2e-141,"d":"2.00E-141"},"Androgen-dependent TFPI-regulating protein",".",".",".",".","pfam04750","Far-17a_AIG1","FAR-17a/AIG1-like protein. This family includes the hamster androgen-induced FAR-17a protein, and its human homologue, the AIG1 protein. The function of these proteins is unknown. This family also includes homologous regions from a number of other metazoan proteins.","GO:0001934|positive regulation of protein phosphorylation;GO:0002042|cell migration involved in sprouting angiogenesis;GO:0002686|negative regulation of leukocyte migration;GO:0003332|negative regulation of extracellular matrix constituent secretion;GO:0010628|positive regulation of gene expression;GO:0030195|negative regulation of blood coagulation;GO:0042758|long-chain fatty acid catabolic process;GO:0043491|protein kinase B signaling;GO:0050709|negative regulation of protein secretion;GO:0071383|cellular response to steroid hormone stimulus;GO:0140052|cellular response to oxidised low-density lipoprotein particle stimulus;GO:1903038|negative regulation of leukocyte cell-cell adhesion;GO:2000402|negative regulation of lymphocyte migration;","GO:0005901|caveola;GO:0009986|cell surface;GO:0012505|endomembrane system;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0016787|hydrolase activity;",".","."]
["ENSRNOG00000000563",93,7.824579984,315,20.26408803,0.386130379,-1.372840033,{"v":9.35002e-19,"d":"9.35E-19"},{"v":2.52903e-18,"d":"2.53E-18"},"down","yes","Adamts14","protein_coding","chr20:29144354-29219866:-","gi|564397940|ref|XP_006256511.1|",6184,0,"PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 14 isoform X1 [Rattus norvegicus]","gi|672086218|ref|XM_006256449.2|",3776,0,"PREDICTED: Rattus norvegicus ADAM metallopeptidase with thrombospondin type 1 motif, 14 (Adamts14), transcript variant X1, mRNA","Q8WXS8",1941,0,"A disintegrin and metalloproteinase with thrombospondin motifs 14",".",".",".",".","pfam05986","ADAM_spacer1","ADAM-TS Spacer 1. This family represents the Spacer-1 region from the ADAM-TS family of metalloproteinases.","GO:0006508|proteolysis;GO:0008150|biological_process;GO:0030198|extracellular matrix organization;GO:0030199|collagen fibril organization;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0031012|extracellular matrix;","GO:0003674|molecular_function;GO:0004222|metalloendopeptidase activity;GO:0008233|peptidase activity;GO:0046872|metal ion binding;","K08628","ADAMTS14; a disintegrin and metalloproteinase with thrombospondin motifs 14 [EC:3.4.24.-]"]
["ENSRNOG00000031211",36,3.028869671,186,11.9654615,0.253134379,-1.982024635,{"v":1.07307e-18,"d":"1.07E-18"},{"v":2.89385e-18,"d":"2.89E-18"},"down","yes","Acsm5","protein_coding","chr1:173863041-173898588:+","gi|33086508|gb|AAP92566.1|",5048,0,"Aa2-174 [Rattus norvegicus]","gi|33086665|gb|AY325244.1|",2865,0,"Rattus norvegicus Cc1-38 mRNA, complete cds","Q6AYT9",1127,0,"Acyl-coenzyme A synthetase ACSM5, mitochondrial","MA2912",363,{"v":8e-113,"d":"8.00E-113"},"COG0365","pfam00501","AMP-binding","AMP-binding enzyme.","GO:0006633|fatty acid biosynthetic process;GO:0006637|acyl-CoA metabolic process;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005759|mitochondrial matrix;","GO:0003674|molecular_function;GO:0004321|fatty-acyl-CoA synthase activity;GO:0005524|ATP binding;GO:0005525|GTP binding;GO:0015645|fatty acid ligase activity;GO:0031956|medium-chain fatty acid-CoA ligase activity;GO:0046872|metal ion binding;GO:0047760|butyrate-CoA ligase activity;","K01896","ACSM; medium-chain acyl-CoA synthetase [EC:6.2.1.2]"]
["ENSRNOG00000017669",172,14.47126621,470,30.23530595,0.478621458,-1.063043017,{"v":1.09318E-18,"d":"1.09E-18"},{"v":2.94518e-18,"d":"2.95E-18"},"down","yes","Chd1l","protein_coding","chr2:185139308-185217595:-","gi|564300746|ref|XP_006224292.1|",4373,0,"PREDICTED: chromodomain-helicase-DNA-binding protein 1-like isoform X1 [Rattus norvegicus]","gi|672016129|ref|XR_599888.1|",3803,0,"PREDICTED: Rattus norvegicus chromodomain helicase DNA binding protein 1-like (Chd1l), transcript variant X3, misc_RNA","Q9CXF7",1484,0,"Chromodomain-helicase-DNA-binding protein 1-like",".",".",".",".","pfam00176","SNF2_N","SNF2 family N-terminal domain. This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1).","GO:0006281|DNA repair;GO:0006338|chromatin remodeling;GO:0006974|cellular response to DNA damage stimulus;GO:0032508|DNA duplex unwinding;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0000166|nucleotide binding;GO:0003678|DNA helicase activity;GO:0005524|ATP binding;","K20092","CHD1L; chromodomain-helicase-DNA-binding protein 1-like [EC:5.6.2.-]"]
["ENSRNOG00000016888",100,8.413526865,329,21.16471416,0.397526128,-1.330878409,{"v":1.0975e-18,"d":"1.10E-18"},{"v":2.95388e-18,"d":"2.95E-18"},"down","yes","Pask","protein_coding","chr9:93844278-93885111:-","gi|57164121|ref|NP_001009362.1|",6941,0,"PAS domain-containing serine/threonine-protein kinase [Rattus norvegicus]","gi|57164120|ref|NM_001009362.1|",4530,0,"Rattus norvegicus PAS domain containing serine/threonine kinase (Pask), mRNA","Q8CEE6",2323,0,"PAS domain-containing serine/threonine-protein kinase","YAL017w_2",184,{"v":9e-50,"d":"9.00E-50"},"COG0515","pfam00069","Pkinase","Protein kinase domain.","GO:0006468|protein phosphorylation;GO:0035556|intracellular signal transduction;GO:0043576|regulation of respiratory gaseous exchange;GO:0045719|negative regulation of glycogen biosynthetic process;GO:0046777|protein autophosphorylation;GO:0070092|regulation of glucagon secretion;GO:0097009|energy homeostasis;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;GO:0035091|phosphatidylinositol binding;","K08801","PASK; PAS domain containing serine/threonine kinase [EC:2.7.11.1]"]
["ENSRNOG00000006645",18,1.514434836,137,8.813270031,0.171835747,-2.540897907,{"v":1.19169e-18,"d":"1.19E-18"},{"v":3.19634e-18,"d":"3.20E-18"},"down","yes","ENSRNOG00000006645","pseudogene","chr3:99432505-99704961:-","gi|378523729|sp|A2AGL3.1|RYR3_MOUSE",19059,0,"RecName: Full=Ryanodine receptor 3; Short=RYR-3; Short=RyR3; AltName: Full=Brain ryanodine receptor-calcium release channel; AltName: Full=Brain-type ryanodine receptor; AltName: Full=Type 3 ryanodine receptor","gi|672046727|ref|XM_008762132.1|",5354,0,"PREDICTED: Rattus norvegicus ryanodine receptor 3 (Ryr3), transcript variant X2, mRNA","A2AGL3",7346,0,"Ryanodine receptor 3",".",".",".",".","pfam06459","RR_TM4-6","Ryanodine Receptor TM 4-6. This region covers TM regions 4-6 of the ryanodine receptor 1 family.","GO:0006816|calcium ion transport;GO:0006874|cellular calcium ion homeostasis;GO:0006941|striated muscle contraction;GO:0051209|release of sequestered calcium ion into cytosol;GO:0051481|negative regulation of cytosolic calcium ion concentration;","GO:0005783|endoplasmic reticulum;GO:0005790|smooth endoplasmic reticulum;GO:0005886|plasma membrane;GO:0030018|Z disc;GO:0030314|junctional membrane complex;GO:0030659|cytoplasmic vesicle membrane;GO:0033017|sarcoplasmic reticulum membrane;GO:0034704|calcium channel complex;GO:0042383|sarcolemma;GO:0048471|perinuclear region of cytoplasm;","GO:0005219|ryanodine-sensitive calcium-release channel activity;GO:0005509|calcium ion binding;GO:0005516|calmodulin binding;GO:0015278|calcium-release channel activity;GO:0048763|calcium-induced calcium release activity;","K04963","RYR3; ryanodine receptor 3"]
["ENSRNOG00000013970",91,7.656309447,310,19.94243584,0.383920475,-1.38112059,{"v":1.22478E-18,"d":"1.22E-18"},{"v":3.28186e-18,"d":"3.28E-18"},"down","yes","Cdt1","protein_coding","chr19:50620713-50625659:+","gi|157818675|ref|NP_001099662.1|",2259,0,"DNA replication factor Cdt1 [Rattus norvegicus]","gi|157818674|ref|NM_001106192.1|",2239,0,"Rattus norvegicus chromatin licensing and DNA replication factor 1 (Cdt1), mRNA","Q8R4E9",795,0,"DNA replication factor Cdt1",".",".",".",".","pfam08839","CDT1","DNA replication factor CDT1 like. CDT1 is a component of the replication licensing system and promotes the loading of the mini-chromosome maintenance complex onto chromatin. Geminin is an inhibitor of CDT1 and prevents inappropriate re-initiation of replication on an already fired origin. This region of CDT1 binds to Geminin.","GO:0000076|DNA replication checkpoint;GO:0000278|mitotic cell cycle;GO:0007059|chromosome segregation;GO:0030174|regulation of DNA-dependent DNA replication initiation;GO:0031334|positive regulation of protein complex assembly;GO:0033044|regulation of chromosome organization;GO:0033262|regulation of nuclear cell cycle DNA replication;GO:0035563|positive regulation of chromatin binding;GO:0045740|positive regulation of DNA replication;GO:0051301|cell division;GO:0051315|attachment of mitotic spindle microtubules to kinetochore;GO:0051383|kinetochore organization;GO:0071163|DNA replication preinitiation complex assembly;GO:0072708|response to sorbitol;GO:1902426|deactivation of mitotic spindle assembly checkpoint;GO:1902595|regulation of DNA replication origin binding;GO:1905341|negative regulation of protein localization to kinetochore;GO:1905342|positive regulation of protein localization to kinetochore;GO:2000105|positive regulation of DNA-dependent DNA replication;","GO:0000776|kinetochore;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0016604|nuclear body;","GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0070182|DNA polymerase binding;","K10727","CDT1; chromatin licensing and DNA replication factor 1"]
["ENSRNOG00000013557",176,14.80780728,476,30.62128858,0.483578842,-1.04817697,{"v":1.6393E-18,"d":"1.64E-18"},{"v":4.35615e-18,"d":"4.36E-18"},"down","yes","Lancl1","protein_coding","chr9:68518574-68548628:-","gi|39930499|ref|NP_446175.1|",2038,0,"lanC-like protein 1 [Rattus norvegicus]","gi|55250743|gb|BC085811.1|",1140,0,"Rattus norvegicus LanC lantibiotic synthetase component C-like 1 (bacterial), mRNA (cDNA clone MGC:93999 IMAGE:7115423), complete cds","Q9QX69",789,0,"LanC-like protein 1",".",".",".",".","pfam05147","LANC_like","Lanthionine synthetase C-like protein. Lanthionines are thioether bridges that are putatively generated by dehydration of Ser and Thr residues followed by addition of cysteine residues within the peptide. This family contains the lanthionine synthetase C-like proteins 1 and 2 which are related to the bacterial lanthionine synthetase components C (LanC). LANCL1 (P40 seven-transmembrane-domain protein) and LANCL2 (testes-specific adriamycin sensitivity protein) are thought to be peptide-modifying enzyme components in eukaryotic cells. Both proteins are produced in large quantities in the brain and testes and may have role in the immune surveillance of these organs. Lanthionines are found in lantibiotics, which are peptide-derived, post-translationally modified antimicrobials produced by several bacterial strains. This region contains seven internal repeats.","GO:0005975|carbohydrate metabolic process;GO:0043523|regulation of neuron apoptotic process;GO:1903203|regulation of oxidative stress-induced neuron death;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;","GO:0004364|glutathione transferase activity;GO:0008270|zinc ion binding;GO:0017124|SH3 domain binding;GO:0043295|glutathione binding;GO:0050750|low-density lipoprotein particle receptor binding;","K25210","LANCL1; glutathione transferase [EC:2.5.1.18]"]
["ENSRNOG00000009779",151,12.70442557,428,27.53342754,0.461418236,-1.115853072,{"v":1.9623E-18,"d":"1.96E-18"},{"v":5.18409e-18,"d":"5.18E-18"},"down","yes","Krt8","protein_coding","chr7:133124203-133131728:-","gi|30352203|gb|AAP31862.1|",1872,0,"cytokeratin-8 [Rattus sp.]","gi|913533|gb|S76054.1|",1323,0,"cytokeratin-8 [rats, prostatic epithelia, mRNA, 1747 nt]","Q10758",721,0,"Keratin, type II cytoskeletal 8",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0033209|tumor necrosis factor-mediated signaling pathway;GO:0045214|sarcomere organization;GO:0051599|response to hydrostatic pressure;GO:0051707|response to other organism;GO:0060706|cell differentiation involved in embryonic placenta development;GO:0097191|extrinsic apoptotic signaling pathway;GO:0097284|hepatocyte apoptotic process;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005882|intermediate filament;GO:0005911|cell-cell junction;GO:0016010|dystrophin-associated glycoprotein complex;GO:0016327|apicolateral plasma membrane;GO:0016363|nuclear matrix;GO:0030018|Z disc;GO:0042383|sarcolemma;GO:0043034|costamere;GO:0045095|keratin filament;GO:0045111|intermediate filament cytoskeleton;GO:0071944|cell periphery;","GO:0005515|protein binding;GO:0044877|protein-containing complex binding;GO:0097110|scaffold protein binding;","K07605","KRT2; type II keratin, basic"]
["ENSRNOG00000017197",146,12.28374922,418,26.89012316,0.45681268,-1.130325398,{"v":2.19472e-18,"d":"2.19E-18"},{"v":5.78969e-18,"d":"5.79E-18"},"down","yes","Pdgfb","protein_coding","chr7:111540345-111557984:-","gi|158081747|ref|NP_113712.1|",1085,{"v":3e-142,"d":"3.00E-142"},"platelet-derived growth factor subunit B precursor [Rattus norvegicus]","gi|158081746|ref|NM_031524.1|",1664,0,"Rattus norvegicus platelet derived growth factor subunit B (Pdgfb), mRNA","P31240",419,{"v":1E-142,"d":"1.00E-142"},"Platelet-derived growth factor subunit B",".",".",".",".","pfam00341","PDGF","PDGF/VEGF domain.","GO:0001568|blood vessel development;GO:0001666|response to hypoxia;GO:0001892|embryonic placenta development;GO:0001938|positive regulation of endothelial cell proliferation;GO:0002548|monocyte chemotaxis;GO:0003104|positive regulation of glomerular filtration;GO:0006468|protein phosphorylation;GO:0006929|substrate-dependent cell migration;GO:0007416|synapse assembly;GO:0007507|heart development;GO:0008284|positive regulation of cell proliferation;GO:0008584|male gonad development;GO:0009410|response to xenobiotic stimulus;GO:0009611|response to wounding;GO:0010033|response to organic substance;GO:0010512|negative regulation of phosphatidylinositol biosynthetic process;GO:0010544|negative regulation of platelet activation;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010811|positive regulation of cell-substrate adhesion;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0014070|response to organic cyclic compound;GO:0014911|positive regulation of smooth muscle cell migration;GO:0016322|neuron remodeling;GO:0018105|peptidyl-serine phosphorylation;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0021782|glial cell development;GO:0030031|cell projection assembly;GO:0030036|actin cytoskeleton organization;GO:0030335|positive regulation of cell migration;GO:0030336|negative regulation of cell migration;GO:0031954|positive regulation of protein autophosphorylation;GO:0032091|negative regulation of protein binding;GO:0032147|activation of protein kinase activity;GO:0032148|activation of protein kinase B activity;GO:0032355|response to estradiol;GO:0032868|response to insulin;GO:0032967|positive regulation of collagen biosynthetic process;GO:0035655|interleukin-18-mediated signaling pathway;GO:0035793|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway;GO:0038001|paracrine signaling;GO:0042060|wound healing;GO:0042127|regulation of cell proliferation;GO:0042462|eye photoreceptor cell development;GO:0043406|positive regulation of MAP kinase activity;GO:0043410|positive regulation of MAPK cascade;GO:0043536|positive regulation of blood vessel endothelial cell migration;GO:0043552|positive regulation of phosphatidylinositol 3-kinase activity;GO:0043627|response to estrogen;GO:0044752|response to human chorionic gonadotropin;GO:0045737|positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045740|positive regulation of DNA replication;GO:0045743|positive regulation of fibroblast growth factor receptor signaling pathway;GO:0045840|positive regulation of mitotic nuclear division;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045977|positive regulation of mitotic cell cycle, embryonic;GO:0048008|platelet-derived growth factor receptor signaling pathway;GO:0048146|positive regulation of fibroblast proliferation;GO:0048514|blood vessel morphogenesis;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0048678|response to axon injury;GO:0050730|regulation of peptidyl-tyrosine phosphorylation;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050918|positive chemotaxis;GO:0050921|positive regulation of chemotaxis;GO:0051781|positive regulation of cell division;GO:0060041|retina development in camera-type eye;GO:0060326|cell chemotaxis;GO:0060445|branching involved in salivary gland morphogenesis;GO:0060664|epithelial cell proliferation involved in salivary gland morphogenesis;GO:0061098|positive regulation of protein tyrosine kinase activity;GO:0061298|retina vasculature development in camera-type eye;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070528|protein kinase C signaling;GO:0071260|cellular response to mechanical stimulus;GO:0071363|cellular response to growth factor stimulus;GO:0071506|cellular response to mycophenolic acid;GO:0072126|positive regulation of glomerular mesangial cell proliferation;GO:0072255|metanephric glomerular mesangial cell development;GO:0072262|metanephric glomerular mesangial cell proliferation involved in metanephros development;GO:0072264|metanephric glomerular endothelium development;GO:0072593|reactive oxygen species metabolic process;GO:0090280|positive regulation of calcium ion import;GO:1900127|positive regulation of hyaluronan biosynthetic process;GO:1902894|negative regulation of pri-miRNA transcription by RNA polymerase II;GO:1902895|positive regulation of pri-miRNA transcription by RNA polymerase II;GO:1904385|cellular response to angiotensin;GO:1904707|positive regulation of vascular smooth muscle cell proliferation;GO:1904754|positive regulation of vascular associated smooth muscle cell migration;GO:1904899|positive regulation of hepatic stellate cell proliferation;GO:1905064|negative regulation of vascular smooth muscle cell differentiation;GO:1905176|positive regulation of vascular smooth muscle cell dedifferentiation;GO:2000379|positive regulation of reactive oxygen species metabolic process;GO:2000491|positive regulation of hepatic stellate cell activation;GO:2000573|positive regulation of DNA biosynthetic process;GO:2000591|positive regulation of metanephric mesenchymal cell migration;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0009986|cell surface;GO:0016020|membrane;GO:0016323|basolateral plasma membrane;GO:0030425|dendrite;GO:0043025|neuronal cell body;","GO:0005102|signaling receptor binding;GO:0005161|platelet-derived growth factor receptor binding;GO:0005518|collagen binding;GO:0008083|growth factor activity;GO:0016176|superoxide-generating NADPH oxidase activator activity;GO:0042056|chemoattractant activity;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0046982|protein heterodimerization activity;GO:0048407|platelet-derived growth factor binding;GO:0070851|growth factor receptor binding;","K17386","PDGFB; platelet-derived growth factor subunit B"]
["ENSRNOG00000000075",155,13.04096664,435,27.98374061,0.466019423,-1.101538011,{"v":2.34889e-18,"d":"2.35E-18"},{"v":6.18739e-18,"d":"6.19E-18"},"down","yes","Mtf2","protein_coding","chr14:1640746-1683524:-","gi|672075467|ref|XP_008768161.1|",3147,0,"PREDICTED: metal-response element-binding transcription factor 2 isoform X1 [Rattus norvegicus]","gi|672075466|ref|XM_008769939.1|",2454,0,"PREDICTED: Rattus norvegicus metal response element binding transcription factor 2 (Mtf2), transcript variant X1, mRNA","Q02395",1177,0,"Metal-response element-binding transcription factor 2",".",".",".",".","pfam14061","Mtf2_C","Polycomb-like MTF2 factor 2. Mammalian Polycomb-like gene MTF2/PCL2 forms a complex with Polycomb repressive complex-2 (PRC2) and collaborates with PRC1 to achieve repression of Hox gene expression. The human MTF2 gene is expressed in three splicing variants, each of them contains the short C-terminal domain defined here. The domain is subject to structure determination by the Joint Center of Structural Genomics.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006325|chromatin organization;GO:0006355|regulation of transcription, DNA-templated;GO:0007379|segment specification;GO:0008150|biological_process;GO:0019827|stem cell population maintenance;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048863|stem cell differentiation;GO:0061086|negative regulation of histone H3-K27 methylation;GO:0061087|positive regulation of histone H3-K27 methylation;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005925|focal adhesion;GO:0035098|ESC/E(Z) complex;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001222|transcription corepressor binding;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0035064|methylated histone binding;GO:0046872|metal ion binding;","K11485","MTF2, PCL2; metal regulatory transcription factor 2"]
["ENSRNOG00000062383",22,1.85097591,147,9.456574413,0.195734293,-2.353031551,{"v":2.41041E-18,"d":"2.41E-18"},{"v":6.34024e-18,"d":"6.34E-18"},"down","yes","Dio2","protein_coding","chr6:109665523-109679809:-","gi|132566529|ref|NP_113908.3|",1398,{"v":1E-174,"d":"1.00E-174"},"type II iodothyronine deiodinase [Rattus norvegicus]","gi|2959448|dbj|AB011068.1|",3423,0,"Rattus rattus mRNA for type II iodothyronine deiodinase, complete cds","P70551",543,{"v":4E-176,"d":"4.00E-176"},"Type II iodothyronine deiodinase",".",".",".",".","pfam00837","T4_deiodinase","Iodothyronine deiodinase. Iodothyronine deiodinase converts thyroxine (T4) to 3,5,3'-triiodothyronine (T3).",".",".",".",".","."]
["ENSRNOG00000010721",185,15.5650247,491,31.58624515,0.492778569,-1.020988579,{"v":2.62265e-18,"d":"2.62E-18"},{"v":6.88521e-18,"d":"6.89E-18"},"down","yes","Dlgap5","protein_coding","chr15:20633966-20664518:-","gi|209447075|ref|NP_001129274.1|",3615,0,"disks large-associated protein 5 [Rattus norvegicus]","gi|672077468|ref|XM_008770506.1|",2453,0,"PREDICTED: Rattus norvegicus discs, large (Drosophila) homolog-associated protein 5 (Dlgap5), transcript variant X2, mRNA","Q8K4R9",969,0,"Disks large-associated protein 5",".",".",".",".","pfam03359","GKAP","Guanylate-kinase-associated protein (GKAP) protein.","GO:0007052|mitotic spindle organization;GO:0007059|chromosome segregation;GO:0007346|regulation of mitotic cell cycle;GO:0023052|signaling;GO:0051382|kinetochore assembly;GO:0051642|centrosome localization;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;GO:0031616|spindle pole centrosome;GO:0034451|centriolar satellite;","GO:0008017|microtubule binding;","K16804","DLGAP5, DLG7; disks large-associated protein 5"]
["ENSRNOG00000050453",149,12.53615503,423,27.21177535,0.460688612,-1.118136158,{"v":2.72161E-18,"d":"2.72E-18"},{"v":7.13125e-18,"d":"7.13E-18"},"down","yes","AABR07002848.1","protein_coding","chr1:83965986-83987778:+","gi|149056452|gb|EDM07883.1|",1249,{"v":4e-158,"d":"4.00E-158"},"rCG54033, isoform CRA_a [Rattus norvegicus]","gi|160333178|ref|NM_001110491.1|",1694,0,"Rattus norvegicus F-box protein 27 (Fbxo27), mRNA","Q6DIA9",458,{"v":3e-149,"d":"3.00E-149"},"F-box only protein 27",".",".",".",".","pfam04300","FBA","F-box associated region. Members of this family are associated with F-box domains, hence the name FBA. This domain is probably involved in binding other proteins that will be targeted for ubiquitination. Human FBXO2 is involved in binding to N-glycosylated proteins.",".",".",".",".","."]
["ENSRNOG00000011777",180,15.14434836,481,30.94294077,0.489428218,-1.030830813,{"v":3.15471E-18,"d":"3.15E-18"},{"v":8.21076e-18,"d":"8.21E-18"},"down","yes","Spag5","protein_coding","chr10:63198768-63216745:+","gi|183986372|gb|AAI66408.1|",5678,0,"Sperm associated antigen 5 [Rattus norvegicus]","gi|112984401|ref|NM_001044224.1|",3799,0,"Rattus norvegicus sperm associated antigen 5 (Spag5), mRNA","Q7TME2",1783,0,"Sperm-associated antigen 5",".",".",".",".","pfam01576","Myosin_tail_1","Myosin tail. The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.","GO:0000070|mitotic sister chromatid segregation;GO:0007051|spindle organization;GO:0007059|chromosome segregation;GO:0032388|positive regulation of intracellular transport;GO:0051294|establishment of spindle orientation;GO:0051301|cell division;GO:0051988|regulation of attachment of spindle microtubules to kinetochore;GO:0071539|protein localization to centrosome;GO:0090235|regulation of metaphase plate congression;GO:1905832|positive regulation of spindle assembly;","GO:0000776|kinetochore;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016604|nuclear body;GO:0034451|centriolar satellite;GO:0035253|ciliary rootlet;GO:0035371|microtubule plus-end;GO:0036064|ciliary basal body;GO:0072686|mitotic spindle;GO:0097431|mitotic spindle pole;","GO:0008017|microtubule binding;","K21764","SPAG5; sperm-associated antigen 5"]
["ENSRNOG00000001692",71,5.973604074,264,16.98323568,0.351735334,-1.507437825,{"v":3.82274e-18,"d":"3.82E-18"},{"v":9.91154e-18,"d":"9.91E-18"},"down","yes","Chaf1b","protein_coding","chr11:33200981-33221070:+","gi|67078530|ref|NP_001019912.1|",2789,0,"chromatin assembly factor 1 subunit B [Rattus norvegicus]","gi|67078529|ref|NM_001024741.1|",1933,0,"Rattus norvegicus chromatin assembly factor 1 subunit B (Chaf1b), mRNA","Q9D0N7",1015,0,"Chromatin assembly factor 1 subunit B",".",".",".",".","pfam15512","CAF-1_p60_C","Chromatin assembly factor complex 1 subunit p60, C-terminal. CAF-1_p60_C is a family of vertebral proteins that is involved in chromatin assembly. CAF-1_p60 is one of the three subunits of the CAF-1 complex, and this domain binds to the C-terminal region of CAF-1_p150, family pfam12253. The N-terminal part of the CAF-1_p60 proteins is a WD-repeat structure, pfam00400.","GO:0006334|nucleosome assembly;GO:0006335|DNA replication-dependent nucleosome assembly;GO:0031497|chromatin assembly;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0032991|protein-containing complex;GO:0033186|CAF-1 complex;",".","K10751","CHAF1B; chromatin assembly factor 1 subunit B"]
["ENSRNOG00000007147",79,6.646686223,281,18.07685313,0.367690448,-1.443436397,{"v":4.15457e-18,"d":"4.15E-18"},{"v":1.07565E-17,"d":"1.08E-17"},"down","yes","Cyp46a1","protein_coding","chr6:127243315-127274760:+","gi|564357223|ref|XP_006240610.1|",2337,0,"PREDICTED: cholesterol 24-hydroxylase isoform X1 [Rattus norvegicus]","gi|157817886|ref|NM_001108723.1|",2458,0,"Rattus norvegicus cytochrome P450, family 46, subfamily a, polypeptide 1 (Cyp46a1), mRNA","Q9WVK8",891,0,"Cholesterol 24-hydroxylase","BH0579",144,{"v":5E-36,"d":"5.00E-36"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0006707|cholesterol catabolic process;GO:0006805|xenobiotic metabolic process;GO:0042448|progesterone metabolic process;GO:1900271|regulation of long-term synaptic potentiation;GO:1903044|protein localization to membrane raft;","GO:0005789|endoplasmic reticulum membrane;GO:0030425|dendrite;GO:0098793|presynapse;GO:0098794|postsynapse;","GO:0005506|iron ion binding;GO:0008395|steroid hydroxylase activity;GO:0020037|heme binding;GO:0033781|cholesterol 24-hydroxylase activity;","K07440","CYP46A1; cholesterol 24-hydroxylase [EC:1.14.14.25]"]
["ENSRNOG00000056658",107,9.002473745,339,21.80801854,0.412805672,-1.276465302,{"v":4.20995e-18,"d":"4.21E-18"},{"v":1.08896e-17,"d":"1.09E-17"},"down","yes","Xylt1","protein_coding","chr1:171643925-171926783:+","gi|564298206|ref|XP_006223520.1|",4562,0,"PREDICTED: xylosyltransferase 1 isoform X1 [Rattus norvegicus]","gi|672014162|ref|XM_006223458.2|",5997,0,"PREDICTED: Rattus norvegicus xylosyltransferase 1 (Xylt1), transcript variant X1, mRNA","Q9EPI1",1685,0,"Xylosyltransferase 1 (Fragment)",".",".",".",".","pfam12529","Xylo_C","Xylosyltransferase C terminal. This domain family is found in eukaryotes, and is typically between 169 and 183 amino acids in length. The family is found in association with pfam02485. There is a single completely conserved residue G that may be functionally important. Xylosyltransferases are enzymes involved in the biosynthesis of the glycosaminoglycan linker region in proteoglycans.","GO:0015012|heparan sulfate proteoglycan biosynthetic process;GO:0030166|proteoglycan biosynthetic process;GO:0030206|chondroitin sulfate biosynthetic process;GO:0034605|cellular response to heat;GO:0043931|ossification involved in bone maturation;GO:0048681|negative regulation of axon regeneration;GO:0048706|embryonic skeletal system development;GO:0050650|chondroitin sulfate proteoglycan biosynthetic process;GO:0070555|response to interleukin-1;","GO:0000137|Golgi cis cisterna;GO:0000139|Golgi membrane;GO:0005575|cellular_component;GO:0005615|extracellular space;","GO:0003674|molecular_function;GO:0030158|protein xylosyltransferase activity;GO:0046872|metal ion binding;","K00771","XYLT; protein xylosyltransferase [EC:2.4.2.26]"]
["ENSRNOG00000018378",116,9.759691163,356,22.90163599,0.426156942,-1.230543261,{"v":5.7969e-18,"d":"5.80E-18"},{"v":1.48743e-17,"d":"1.49E-17"},"down","yes","Cacnb2","protein_coding","chr17:77564460-77909106:+","gi|149021129|gb|EDL78736.1|",2658,0,"calcium channel, voltage-dependent, beta 2 subunit, isoform CRA_a [Rattus norvegicus]","gi|16758715|ref|NM_053851.1|",3479,0,"Rattus norvegicus calcium voltage-gated channel auxiliary subunit beta 2 (Cacnb2), mRNA","Q8VGC3",1028,0,"Voltage-dependent L-type calcium channel subunit beta-2",".",".",".",".","pfam00625","Guanylate_kin","Guanylate kinase.","GO:0006816|calcium ion transport;GO:0007268|chemical synaptic transmission;GO:0007528|neuromuscular junction development;GO:0007601|visual perception;GO:0034765|regulation of ion transmembrane transport;GO:0051928|positive regulation of calcium ion transport;GO:0070509|calcium ion import;GO:0070588|calcium ion transmembrane transport;GO:0072659|protein localization to plasma membrane;GO:0086045|membrane depolarization during AV node cell action potential;GO:0086091|regulation of heart rate by cardiac conduction;GO:0098912|membrane depolarization during atrial cardiac muscle cell action potential;GO:0099703|induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration;GO:1901385|regulation of voltage-gated calcium channel activity;GO:1901843|positive regulation of high voltage-gated calcium channel activity;GO:1904879|positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel;","GO:0005891|voltage-gated calcium channel complex;GO:0042383|sarcolemma;GO:0098684|photoreceptor ribbon synapse;GO:0098793|presynapse;GO:1990454|L-type voltage-gated calcium channel complex;","GO:0005245|voltage-gated calcium channel activity;GO:0005246|calcium channel regulator activity;GO:0005515|protein binding;GO:0008331|high voltage-gated calcium channel activity;GO:0019901|protein kinase binding;GO:0019904|protein domain specific binding;GO:0042802|identical protein binding;GO:0051015|actin filament binding;GO:0051219|phosphoprotein binding;GO:0086007|voltage-gated calcium channel activity involved in cardiac muscle cell action potential;GO:0086056|voltage-gated calcium channel activity involved in AV node cell action potential;GO:0099635|voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels;","K04863","CACNB2; voltage-dependent calcium channel beta-2"]
["ENSRNOG00000027730",149,12.53615503,420,27.01878404,0.463979245,-1.107867822,{"v":6.2972e-18,"d":"6.30E-18"},{"v":1.6131e-17,"d":"1.61E-17"},"down","yes","Nxpe1","protein_coding","chr8:48751014-48785353:+","gi|564363589|ref|XP_006243080.1|",2997,0,"PREDICTED: NXPE family member 1 isoform X1 [Rattus norvegicus]","gi|672061782|ref|XM_006243018.2|",2597,0,"PREDICTED: Rattus norvegicus similar to protein of unknown function (RGD1566243), transcript variant X1, mRNA","Q8N323",755,0,"NXPE family member 1",".",".",".",".","pfam06312","Neurexophilin","Neurexophilin. This family consists of mammalian neurexophilin proteins. Mammalian brains contain four different neurexophilin proteins. Neurexophilins form a family of related glycoproteins that are proteolytically processed after synthesis and bind to alpha-neurexins. The structure and characteristics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins.",".",".",".",".","."]
["ENSRNOG00000021765",185,15.5650247,486,31.26459296,0.497848308,-1.006221868,{"v":9.61335e-18,"d":"9.61E-18"},{"v":2.44595e-17,"d":"2.45E-17"},"down","yes","Gli4","protein_coding","chr7:107325607-107330907:+","gi|71361639|ref|NP_001025097.1|",1755,0,"zinc finger protein GLI4 [Rattus norvegicus]","gi|672059528|ref|XM_006241856.2|",1474,0,"PREDICTED: Rattus norvegicus GLI family zinc finger 4 (Gli4), transcript variant X1, mRNA","P10075",476,{"v":6e-156,"d":"6.00E-156"},"Zinc finger protein GLI4",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0006357|regulation of transcription by RNA polymerase II;",".","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;",".","."]
["ENSRNOG00000006783",50,4.206763432,214,13.76671377,0.305574991,-1.710401622,{"v":1.08479e-17,"d":"1.08E-17"},{"v":2.75363E-17,"d":"2.75E-17"},"down","yes","Neb","protein_coding","chr3:36613716-36811574:-","gi|537146910|gb|ERE70307.1|",36392,0,"nebulin-like protein [Cricetulus griseus]","gi|568913112|ref|XM_006497765.1|",17931,0,"PREDICTED: Mus musculus nebulin (Neb), transcript variant X17, mRNA","P20929",8955,0,"Nebulin",".",".",".",".","pfam14604","SH3_9","Variant SH3 domain.","GO:0071691|cardiac muscle thin filament assembly;","GO:0030016|myofibril;GO:0030018|Z disc;GO:0043292|contractile fiber;","GO:0051015|actin filament binding;","K18267","NEB; nebulin"]
["ENSRNOG00000009447",116,9.759691163,353,22.70864468,0.429778672,-1.218334203,{"v":1.42941e-17,"d":"1.43E-17"},{"v":3.6082e-17,"d":"3.61E-17"},"down","yes","Fam221a","protein_coding","chr4:78337296-78358909:+","gi|148666193|gb|EDK98609.1|",1439,0,"RIKEN cDNA D330028D13, isoform CRA_b, partial [Mus musculus]","gi|672049609|ref|XM_006236468.2|",1344,0,"PREDICTED: Rattus norvegicus family with sequence similarity 221, member A (Fam221a), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam14753","DUF4475","Domain of unknown function (DUF4475). This family of proteins is found in eukaryotes. Proteins in this family are typically between 99 and 305 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000025527",181,15.22848363,477,30.68561901,0.496274285,-1.010790394,{"v":1.45706e-17,"d":"1.46E-17"},{"v":3.67459e-17,"d":"3.67E-17"},"down","yes","Mtcl1","protein_coding","chr9:106321098-106442203:-","gi|569001477|ref|XP_006524915.1|",8051,0,"PREDICTED: microtubule cross-linking factor 1 isoform X4 [Mus musculus]","gi|672066369|ref|XM_006245631.2|",5756,0,"PREDICTED: Rattus norvegicus microtubule crosslinking factor 1 (Mtcl1), transcript variant X10, mRNA","Q3UHU5",3006,0,"Microtubule cross-linking factor 1",".",".",".",".","pfam14818","DUF4482","Domain of unknown function (DUF4482). This family is found in eukaryotes, and is approximately 140 amino acids in length. The family is found in association with pfam11365.","GO:0001578|microtubule bundle formation;GO:0010506|regulation of autophagy;GO:0045197|establishment or maintenance of epithelial cell apical/basal polarity;GO:0090314|positive regulation of protein targeting to membrane;","GO:0000922|spindle pole;GO:0005615|extracellular space;GO:0005856|cytoskeleton;GO:0016327|apicolateral plasma membrane;GO:0016328|lateral plasma membrane;GO:0030496|midbody;GO:0097427|microtubule bundle;","GO:0008017|microtubule binding;GO:0042803|protein homodimerization activity;",".","."]
["ENSRNOG00000028330",22,1.85097591,143,9.19925266,0.201209378,-2.313230543,{"v":1.47086e-17,"d":"1.47E-17"},{"v":3.70598e-17,"d":"3.71E-17"},"down","yes","AABR07067600.1","protein_coding","chr9:48763742-48764305:-","gi|507572163|ref|XP_004669676.1|",367,{"v":3e-53,"d":"3.00E-53"},"PREDICTED: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [Jaculus jaculus]","gi|480359913|gb|KC660101.1|",458,0,"Rattus norvegicus BCL2/adenovirus E1B interacting protein 3 variant (Bnip3) mRNA, complete cds, alternatively spliced","O55003",154,{"v":6e-46,"d":"6.00E-46"},"BCL2/adenovirus E1B 19 kDa protein-interacting protein 3",".",".",".",".","pfam06553","BNIP3","BNIP3. This family consists of several mammalian specific BCL2/adenovirus E1B 19-kDa protein-interacting protein 3 or BNIP3 sequences. BNIP3 belongs to the Bcl-2 homology 3 (BH3)-only family, a Bcl-2-related family possessing an atypical Bcl-2 homology 3 (BH3) domain, which regulates PCD from mitochondrial sites by selective Bcl-2/Bcl-XL interactions. BNIP3 family members contain a C-terminal transmembrane domain that is required for their mitochondrial localisation, homodimerization, as well as regulation of their pro-apoptotic activities. BNIP3-mediated apoptosis has been reported to be independent of caspase activation and cytochrome c release and is characterized by early plasma membrane and mitochondrial damage, prior to the appearance of chromatin condensation or DNA fragmentation.",".",".",".",".","."]
["ENSRNOG00000017981",84,7.067362566,287,18.46283576,0.382788574,-1.385380329,{"v":1.91107e-17,"d":"1.91E-17"},{"v":4.78632E-17,"d":"4.79E-17"},"down","yes","Mcm10","protein_coding","chr17:73266095-73287364:+","gi|157819197|ref|NP_001100836.1|",4354,0,"protein MCM10 homolog [Rattus norvegicus]","gi|157819196|ref|NM_001107366.1|",3942,0,"Rattus norvegicus minichromosome maintenance 10 replication initiation factor (Mcm10), mRNA","Q0VBD2",1438,0,"Protein MCM10 homolog",".",".",".",".","pfam09332","Mcm10","Mcm10 replication factor. Mcm10 is a eukaryotic DNA replication factor that regulates the stability and chromatin association of DNA polymerase alpha.","GO:0006270|DNA replication initiation;GO:0006974|cellular response to DNA damage stimulus;GO:0008283|cell proliferation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0031298|replication fork protection complex;","GO:0003688|DNA replication origin binding;GO:0003697|single-stranded DNA binding;GO:0019899|enzyme binding;GO:0042802|identical protein binding;GO:0046872|metal ion binding;","K10736","MCM10; minichromosome maintenance protein 10"]
["ENSRNOG00000014002",158,13.29337245,433,27.85507973,0.47723333,-1.067233292,{"v":1.93114E-17,"d":"1.93E-17"},{"v":4.83438E-17,"d":"4.83E-17"},"down","yes","St7l","protein_coding","chr2:192364594-192487190:+","gi|56090251|ref|NP_001007640.1|",2882,0,"suppressor of tumorigenicity 7 protein-like [Rattus norvegicus]","gi|56090250|ref|NM_001007639.1|",2241,0,"Rattus norvegicus suppression of tumorigenicity 7-like (St7l), mRNA","Q68FW3",1114,0,"Suppressor of tumorigenicity 7 protein-like","SPAC13G6.07c",139,{"v":2e-48,"d":"2.00E-48"},"COG2125","pfam04184","ST7","ST7 protein. The ST7 (for suppression of tumorigenicity 7) protein is thought to be a tumor suppressor gene. The molecular function of this protein is uncertain.","GO:0006412|translation;GO:0030308|negative regulation of cell growth;","GO:0005840|ribosome;GO:0016021|integral component of membrane;","GO:0003735|structural constituent of ribosome;",".","."]
["ENSRNOG00000029330",180,15.14434836,474,30.4926277,0.496656061,-1.009680978,{"v":1.96337e-17,"d":"1.96E-17"},{"v":4.91054e-17,"d":"4.91E-17"},"down","yes","Ca5b","protein_coding","chrX:30474784-30533837:+","gi|53850632|ref|NP_001005551.1|",1602,0,"carbonic anhydrase 5B, mitochondrial precursor [Rattus norvegicus]","gi|672087334|ref|XM_006256859.2|",1811,0,"PREDICTED: Rattus norvegicus carbonic anhydrase 5b, mitochondrial (Car5b), transcript variant X1, mRNA","Q66HG6",621,0,"Carbonic anhydrase 5B, mitochondrial","BH0360",114,{"v":4e-27,"d":"4.00E-27"},"COG3338","pfam00194","Carb_anhydrase","Eukaryotic-type carbonic anhydrase.","GO:0006730|one-carbon metabolic process;GO:0009617|response to bacterium;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;","GO:0004089|carbonate dehydratase activity;GO:0008270|zinc ion binding;GO:0016836|hydro-lyase activity;","K01672","CA; carbonic anhydrase [EC:4.2.1.1]"]
["ENSRNOG00000030170",69,5.805333537,254,16.3399313,0.355285064,-1.492951055,{"v":2.73797e-17,"d":"2.74E-17"},{"v":6.80723e-17,"d":"6.81E-17"},"down","yes","Krt10","protein_coding","chr10:84338706-84343701:-","gi|672068846|ref|XP_008766313.1|",1523,0,"PREDICTED: keratin, type I cytoskeletal 10 isoform X1 [Rattus norvegicus]","gi|672068847|ref|XM_006247391.2|",2780,0,"PREDICTED: Rattus norvegicus keratin 10 (Krt10), transcript variant X2, mRNA","Q6IFW6",589,0,"Keratin, type I cytoskeletal 10",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0003334|keratinocyte development;GO:0008150|biological_process;GO:0008544|epidermis development;GO:0018149|peptide cross-linking;GO:0030216|keratinocyte differentiation;GO:0030855|epithelial cell differentiation;GO:0045109|intermediate filament organization;GO:0045684|positive regulation of epidermis development;GO:0051290|protein heterotetramerization;GO:0071277|cellular response to calcium ion;","GO:0001533|cornified envelope;GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005882|intermediate filament;GO:0045095|keratin filament;","GO:0003674|molecular_function;GO:0005198|structural molecule activity;GO:0008092|cytoskeletal protein binding;GO:0030280|structural constituent of epidermis;GO:0046982|protein heterodimerization activity;","K07604","KRT1; type I keratin, acidic"]
["ENSRNOG00000027040",152,12.78856083,420,27.01878404,0.473321109,-1.079108829,{"v":3.03907e-17,"d":"3.04E-17"},{"v":7.54549e-17,"d":"7.55E-17"},"down","yes","ENSRNOG00000027040","protein_coding","chr15:99968282-99993455:-","gi|849568472|ref|NP_001020805.2|",812,{"v":1e-98,"d":"1.00E-98"},"gamma-glutamylaminecyclotransferase [Rattus norvegicus]","gi|672079162|ref|XM_006252522.2|",1179,0,"PREDICTED: Rattus norvegicus gamma-glutamylamine cyclotransferase (Ggact), transcript variant X11, mRNA","Q4KM86",301,{"v":2e-94,"d":"2.00E-94"},"Gamma-glutamylaminecyclotransferase","MJ1514",57.8,1E-8,"COG2105","pfam06094","AIG2","AIG2-like family. AIG2 is an Arabidopsis proteins that exhibit RPS2- and avrRpt2-dependent induction early after infection with Pseudomonas syringae pv maculicola strain ES4326 carrying avrRpt2.","GO:0042219|cellular modified amino acid catabolic process;","GO:0005829|cytosol;","GO:0061929|gamma-glutamylaminecyclotransferase activity;","K19761","GGACT; gamma-glutamylaminecyclotransferase [EC:2.3.2.-]"]
["ENSRNOG00000049056",94,7.908715253,306,19.68511408,0.40176121,-1.315589816,{"v":3.30635E-17,"d":"3.31E-17"},{"v":8.19415e-17,"d":"8.19E-17"},"down","yes","AABR07051450.1","protein_coding","chr3:15912485-15923041:+","gi|830005084|ref|XP_004677358.2|",954,{"v":2E-121,"d":"2.00E-121"},"PREDICTED: adenylate kinase isoenzyme 1 isoform X1 [Condylura cristata]","gi|467091434|ref|NM_024349.3|",1974,0,"Rattus norvegicus adenylate kinase 1 (Ak1), mRNA","P39069",366,{"v":3e-121,"d":"3.00E-121"},"Adenylate kinase isoenzyme 1","YKL024c",157,{"v":5e-43,"d":"5.00E-43"},"COG0563","pfam00406","ADK","Adenylate kinase.",".",".",".",".","."]
["ENSRNOG00000025587",104,8.750067939,326,20.97172285,0.417231717,-1.261079261,{"v":3.60867e-17,"d":"3.61E-17"},{"v":8.93121e-17,"d":"8.93E-17"},"down","yes","Plagl1","protein_coding","chr1:7477177-7517228:+","gi|6981166|ref|NP_036892.1|",2080,0,"zinc finger protein PLAGL1 [Rattus norvegicus]","gi|158819032|ref|NM_012760.3|",2453,0,"Rattus norvegicus PLAG1 like zinc finger 1 (Plagl1), mRNA","Q9UM63",578,0,"Zinc finger protein PLAGL1","ECU03g0790",72,{"v":1e-12,"d":"1.00E-12"},"COG5048","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0006355|regulation of transcription, DNA-templated;GO:0010468|regulation of gene expression;GO:0035914|skeletal muscle cell differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005794|Golgi apparatus;GO:0016604|nuclear body;GO:0043231|intracellular membrane-bounded organelle;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;","K19485","PLAGL1; zinc finger protein PLAGL1"]
["ENSRNOG00000013027",175,14.72367201,462,29.72066244,0.495401879,-1.013328755,{"v":4.00718E-17,"d":"4.01E-17"},{"v":9.89501e-17,"d":"9.90E-17"},"down","yes","Rgl3","pseudogene","chr8:20500846-20520471:-","gi|672060903|ref|XP_006242692.2|",3058,0,"PREDICTED: ral guanine nucleotide dissociation stimulator-like 3 isoform X1 [Rattus norvegicus]","gi|672060902|ref|XM_006242630.2|",2453,0,"PREDICTED: Rattus norvegicus ral guanine nucleotide dissociation stimulator-like 3 (Rgl3), transcript variant X1, mRNA","Q3UYI5",1056,0,"Ral guanine nucleotide dissociation stimulator-like 3",".",".",".",".","pfam00617","RasGEF","RasGEF domain. Guanine nucleotide exchange factor for Ras-like small GTPases.","GO:0007264|small GTPase mediated signal transduction;GO:0043547|positive regulation of GTPase activity;",".","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0031267|small GTPase binding;","K17639","RGL3; ral guanine nucleotide dissociation stimulator-like 3"]
["ENSRNOG00000031641",147,12.36788449,409,26.31114922,0.470062497,-1.089075513,{"v":4.61222e-17,"d":"4.61E-17"},{"v":1.13633e-16,"d":"1.14E-16"},"down","yes","Rpl35a","protein_coding","chr5:158537765-158544128:+","gi|148665412|gb|EDK97828.1|",596,{"v":6e-76,"d":"6.00E-76"},"mCG130125, isoform CRA_b, partial [Mus musculus]","gi|298891855|emb|FQ217774.1|",452,0,"Rattus norvegicus TL0ACA18YC08 mRNA sequence","P04646",227,{"v":3e-75,"d":"3.00E-75"},"60S ribosomal protein L35a","YOR234c",108,{"v":2e-29,"d":"2.00E-29"},"COG2451","pfam01247","Ribosomal_L35Ae","Ribosomal protein L35Ae.","GO:0006364|rRNA processing;GO:0008150|biological_process;GO:0042273|ribosomal large subunit biogenesis;","GO:0022625|cytosolic large ribosomal subunit;GO:0022626|cytosolic ribosome;","GO:0000049|tRNA binding;GO:0003735|structural constituent of ribosome;GO:0043021|ribonucleoprotein complex binding;","K02917","RP-L35Ae, RPL35A; large subunit ribosomal protein L35Ae"]
["ENSRNOG00000046566",82,6.899092029,280,18.01252269,0.383016424,-1.384521838,{"v":4.82708e-17,"d":"4.83E-17"},{"v":1.18819e-16,"d":"1.19E-16"},"down","yes","Tub","protein_coding","chr1:162951931-163026812:+","gi|795247956|ref|XP_011809763.1|",2058,0,"PREDICTED: tubby protein homolog isoform X1 [Colobus angolensis palliatus]","gi|672037725|ref|XM_008759690.1|",1536,0,"PREDICTED: Rattus norvegicus tubby bipartite transcription factor (Tub), transcript variant X1, mRNA","P50607",747,0,"Tubby protein homolog",".",".",".",".","pfam01167","Tub","Tub family.","GO:0006910|phagocytosis, recognition;GO:0007605|sensory perception of sound;GO:0008277|regulation of G protein-coupled receptor signaling pathway;GO:0009725|response to hormone;GO:0042073|intraciliary transport;GO:0045494|photoreceptor cell maintenance;GO:0050766|positive regulation of phagocytosis;GO:0060041|retina development in camera-type eye;GO:0061512|protein localization to cilium;GO:0097500|receptor localization to non-motile cilium;GO:1903546|protein localization to photoreceptor outer segment;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005929|cilium;","GO:0001664|G protein-coupled receptor binding;GO:0003674|molecular_function;GO:0044877|protein-containing complex binding;GO:0120160|intraciliary transport particle A binding;","K19600","TUB, TULP; tubby and related proteins"]
["ENSRNOG00000062844",109,9.170744282,334,21.48636635,0.4268169,-1.228310793,{"v":6.63129e-17,"d":"6.63E-17"},{"v":1.62715E-16,"d":"1.63E-16"},"down","yes","ENSRNOG00000062844","lncRNA","chrX:111828102-111848636:-","gi|343473615|emb|CCD14538.1|",380,{"v":5e-35,"d":"5.00E-35"},"unnamed protein product [Trypanosoma congolense IL3000]","gi|672088436|ref|XR_362556.2|",4658,0,"PREDICTED: Rattus norvegicus uncharacterized LOC100911253 (LOC100911253), transcript variant X5, ncRNA","P11369",153,{"v":1E-35,"d":"1.00E-35"},"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam06762","LMF1","Lipase maturation factor. This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. The precise role of LMF1 in lipase folding has yet to be determined.",".",".",".",".","."]
["ENSRNOG00000016603",41,3.449546015,188,12.09412238,0.285224997,-1.809827672,{"v":6.88491e-17,"d":"6.88E-17"},{"v":1.68786e-16,"d":"1.69E-16"},"down","yes","Rtn2","protein_coding","chr1:78935104-78948069:+","gi|42476339|ref|NP_963856.1|",2098,0,"reticulon-2 [Rattus norvegicus]","gi|42521116|tpg|BK001788.2|",1961,0,"TPA_inf: Rattus norvegicus RTN2-B (Rtn2) mRNA, complete cds","O70622",758,0,"Reticulon-2",".",".",".",".","pfam02453","Reticulon","Reticulon. Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of unknown function which associates with the endoplasmic reticulum. This family represents the C-terminal domain of the three reticulon isoforms and their homologues.","GO:0010467|gene expression;GO:0015031|protein transport;GO:0046324|regulation of glucose import;GO:0065002|intracellular protein transmembrane transport;GO:1902430|negative regulation of amyloid-beta formation;","GO:0005783|endoplasmic reticulum;GO:0005882|intermediate filament;GO:0009986|cell surface;GO:0014802|terminal cisterna;GO:0016021|integral component of membrane;GO:0030018|Z disc;GO:0030315|T-tubule;GO:0033017|sarcoplasmic reticulum membrane;","GO:0005515|protein binding;","K20722","RTN2; reticulon-2"]
["ENSRNOG00000022844",31,2.608193328,163,10.48586142,0.248734293,-2.007322669,{"v":7.92785e-17,"d":"7.93E-17"},{"v":1.9383e-16,"d":"1.94E-16"},"down","yes","Pdzrn4","protein_coding","chr7:123816961-123965491:+","gi|257196174|ref|NP_001101577.2|",3738,0,"PDZ domain containing RING finger 4 [Rattus norvegicus]","gi|257196173|ref|NM_001108107.2|",3368,0,"Rattus norvegicus PDZ domain containing RING finger 4 (Pdzrn4), mRNA","Q6ZMN7",1203,0,"PDZ domain-containing RING finger protein 4",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.",".",".",".","K15682","PDZRN3_4, LNX3_4; ligand of Numb protein X 3/4 [EC:2.3.2.27]"]
["ENSRNOG00000066624",14,1.177893761,116,7.462330829,0.157845288,-2.663416898,{"v":8.48495e-17,"d":"8.48E-17"},{"v":2.07228e-16,"d":"2.07E-16"},"down","yes","ENSRNOG00000066624","lncRNA","chr14:94563775-94574801:-",".",".",".",".","gi|672028179|ref|XR_340440.2|",2547,0,"PREDICTED: Rattus norvegicus uncharacterized LOC100911950 (LOC100911950), ncRNA",".",".",".",".",".",".",".",".","pfam10977","DUF2797","Protein of unknown function (DUF2797). This family of proteins has no known function.",".",".",".",".","."]
["ENSRNOG00000018254",46,3.870222358,199,12.8017572,0.302319619,-1.72585349,{"v":9.46728e-17,"d":"9.47E-17"},{"v":2.30022e-16,"d":"2.30E-16"},"down","yes","Sncaip","protein_coding","chr18:46207152-46343929:+","gi|157817380|ref|NP_001100849.1|",4612,0,"synphilin-1 [Rattus norvegicus]","gi|157817379|ref|NM_001107379.1|",3803,0,"Rattus norvegicus synuclein, alpha interacting protein (Sncaip), mRNA","Q99ME3",1656,0,"Synphilin-1","Ta0196",53.9,5e-07,"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0008219|cell death;GO:0042417|dopamine metabolic process;GO:0046928|regulation of neurotransmitter secretion;GO:0090083|regulation of inclusion body assembly;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0036464|cytoplasmic ribonucleoprotein granule;","GO:0031625|ubiquitin protein ligase binding;GO:0042802|identical protein binding;","K04558","SNCAIP; synphilin-1"]
["ENSRNOG00000012137",172,14.47126621,452,29.07735806,0.497681604,-1.006705033,{"v":1.27121E-16,"d":"1.27E-16"},{"v":3.06398e-16,"d":"3.06E-16"},"down","yes","Cenatac","protein_coding","chr8:44735972-44742837:-","gi|109483359|ref|XP_001060013.1|",1522,0,"PREDICTED: coiled-coil domain-containing protein 84 isoform X3 [Rattus norvegicus]","gi|672022735|ref|XM_003754411.3|",1188,0,"PREDICTED: Rattus norvegicus coiled-coil domain containing 84 (Ccdc84), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam14968","CCDC84","Coiled coil protein 84. The function of this coiled-coil domain-containing family is not known. It is found in eukaryotes.","GO:0010826|negative regulation of centrosome duplication;GO:0042176|regulation of protein catabolic process;","GO:0005813|centrosome;",".",".","."]
["ENSRNOG00000005410",99,8.329391596,311,20.00676628,0.41632873,-1.264204975,{"v":1.65464E-16,"d":"1.65E-16"},{"v":3.96186e-16,"d":"3.96E-16"},"down","yes","Cdca7l","protein_coding","chr6:138794228-138839888:+","gi|77993356|ref|NP_001030125.1|",1834,0,"cell division cycle-associated 7-like protein [Rattus norvegicus]","gi|256985238|gb|AC118412.6|",5478,0,"Rattus norvegicus CH230-221E17 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q4G059",711,0,"Cell division cycle-associated 7-like protein",".",".",".",".","pfam10497","zf-4CXXC_R1","Zinc-finger domain of monoamine-oxidase A repressor R1. R1 is a transcription factor repressor that inhibits monoamine oxidase A gene expression. This domain is a four-CXXC zinc finger putative DNA-binding domain found at the C-terminal end of R1. The domain carries 12 cysteines of which four pairs are of the CXXC type.","GO:0006355|regulation of transcription, DNA-templated;GO:0008284|positive regulation of cell proliferation;","GO:0001650|fibrillar center;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005829|cytosol;",".",".","."]
["ENSRNOG00000020951",8,0.673082149,95,6.111391628,0.11013566,-3.182646434,{"v":1.91638e-16,"d":"1.92E-16"},{"v":4.57507e-16,"d":"4.58E-16"},"down","yes","Slc4a1","protein_coding","chr10:87306872-87323117:-","gi|76443687|ref|NP_036783.2|",3965,0,"band 3 anion transport protein [Rattus norvegicus]","gi|55250403|gb|BC085748.1|",3538,0,"Rattus norvegicus solute carrier family 4 (anion exchanger), member 1, mRNA (cDNA clone MGC:93554 IMAGE:7126960), complete cds","P23562",1523,0,"Band 3 anion transport protein",".",".",".",".","pfam00955","HCO3_cotransp","HCO3- transporter family. This family contains Band 3 anion exchange proteins that exchange CL-/HCO3-. This family also includes cotransporters of Na+/HCO3-.","GO:0006820|anion transport;GO:0006821|chloride transport;GO:0007596|blood coagulation;GO:0007623|circadian rhythm;GO:0009414|response to water deprivation;GO:0010037|response to carbon dioxide;GO:0010446|response to alkaline pH;GO:0010447|response to acidic pH;GO:0014823|response to activity;GO:0015698|inorganic anion transport;GO:0015701|bicarbonate transport;GO:0017121|phospholipid scrambling;GO:0031667|response to nutrient levels;GO:0035811|negative regulation of urine volume;GO:0042102|positive regulation of T cell proliferation;GO:0042542|response to hydrogen peroxide;GO:0045852|pH elevation;GO:0046685|response to arsenic-containing substance;GO:0048821|erythrocyte development;GO:0050801|ion homeostasis;GO:0051354|negative regulation of oxidoreductase activity;GO:0051453|regulation of intracellular pH;GO:0055085|transmembrane transport;GO:0072659|protein localization to plasma membrane;GO:0098656|anion transmembrane transport;GO:1902476|chloride transmembrane transport;GO:1904539|negative regulation of glycolytic process through fructose-6-phosphate;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009898|cytoplasmic side of plasma membrane;GO:0009986|cell surface;GO:0014704|intercalated disc;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0030018|Z disc;GO:0030863|cortical cytoskeleton;","GO:0003779|actin binding;GO:0005452|inorganic anion exchanger activity;GO:0008022|protein C-terminus binding;GO:0015106|bicarbonate transmembrane transporter activity;GO:0015108|chloride transmembrane transporter activity;GO:0015301|anion:anion antiporter activity;GO:0019899|enzyme binding;GO:0022857|transmembrane transporter activity;GO:0030492|hemoglobin binding;GO:0030506|ankyrin binding;GO:0042803|protein homodimerization activity;GO:0044877|protein-containing complex binding;","K06573","SLC4A1, AE1, CD233; solute carrier family 4 (anion exchanger), member 1"]
["ENSRNOG00000025792",152,12.78856083,413,26.56847097,0.481343501,-1.054861283,{"v":2.02355e-16,"d":"2.02E-16"},{"v":4.81132e-16,"d":"4.81E-16"},"down","yes","Crk","protein_coding","chr10:60530464-60553406:+","gi|16603739|gb|AAL27153.1|",1302,{"v":6E-175,"d":"6.00E-175"},"CT-10 related kinase 3 [Mus musculus]","gi|354799955|gb|JN964456.1|",1000,0,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Crk:tm1e(EUCOMM)Hmgu; transgenic","Q63768",469,{"v":1E-161,"d":"1.00E-161"},"Adapter molecule crk",".",".",".",".","pfam00017","SH2","SH2 domain.","GO:0001764|neuron migration;GO:0001878|response to yeast;GO:0002685|regulation of leukocyte migration;GO:0006629|lipid metabolic process;GO:0007165|signal transduction;GO:0008360|regulation of cell shape;GO:0009966|regulation of signal transduction;GO:0014911|positive regulation of smooth muscle cell migration;GO:0016358|dendrite development;GO:0016477|cell migration;GO:0021766|hippocampus development;GO:0021987|cerebral cortex development;GO:0030010|establishment of cell polarity;GO:0030036|actin cytoskeleton organization;GO:0030307|positive regulation of cell growth;GO:0032956|regulation of actin cytoskeleton organization;GO:0033628|regulation of cell adhesion mediated by integrin;GO:0035020|regulation of Rac protein signal transduction;GO:0035685|helper T cell diapedesis;GO:0035728|response to hepatocyte growth factor;GO:0038026|reelin-mediated signaling pathway;GO:0042542|response to hydrogen peroxide;GO:0043087|regulation of GTPase activity;GO:0043393|regulation of protein binding;GO:0045953|negative regulation of natural killer cell mediated cytotoxicity;GO:0048013|ephrin receptor signaling pathway;GO:0050773|regulation of dendrite development;GO:0051270|regulation of cellular component movement;GO:0060326|cell chemotaxis;GO:0061045|negative regulation of wound healing;GO:0061847|response to cholecystokinin;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0071732|cellular response to nitric oxide;GO:0090630|activation of GTPase activity;GO:0098749|cerebellar neuron development;GO:1900026|positive regulation of substrate adhesion-dependent cell spreading;GO:1901652|response to peptide;GO:1902531|regulation of intracellular signal transduction;GO:1990090|cellular response to nerve growth factor stimulus;GO:1990314|cellular response to insulin-like growth factor stimulus;GO:1990859|cellular response to endothelin;GO:2000146|negative regulation of cell motility;GO:2000404|regulation of T cell migration;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0015629|actin cytoskeleton;GO:0016020|membrane;GO:0032991|protein-containing complex;GO:0045121|membrane raft;","GO:0001784|phosphotyrosine residue binding;GO:0005159|insulin-like growth factor receptor binding;GO:0005515|protein binding;GO:0008092|cytoskeletal protein binding;GO:0017124|SH3 domain binding;GO:0019899|enzyme binding;GO:0019900|kinase binding;GO:0019904|protein domain specific binding;GO:0030159|receptor signaling complex scaffold activity;GO:0030674|protein binding, bridging;GO:0030971|receptor tyrosine kinase binding;GO:0031625|ubiquitin protein ligase binding;GO:0035591|signaling adaptor activity;GO:0042169|SH2 domain binding;GO:0043621|protein self-association;GO:0045309|protein phosphorylated amino acid binding;GO:0046875|ephrin receptor binding;GO:0097110|scaffold protein binding;GO:1990782|protein tyrosine kinase binding;","K04438","CRK, CRKII; C-crk adapter molecule crk"]
["ENSRNOG00000068250",97,8.161121059,306,19.68511408,0.414583376,-1.270265826,{"v":2.23379e-16,"d":"2.23E-16"},{"v":5.29732e-16,"d":"5.30E-16"},"down","yes","ENSRNOG00000068250","lncRNA","chr9:105766167-105772713:-","gi|377837122|ref|XP_003688804.1|",541,{"v":3e-55,"d":"3.00E-55"},"PREDICTED: sperm motility kinase W [Mus musculus]","gi|186965653|gb|AC103346.5|",330,{"v":7e-170,"d":"7.00E-170"},"Rattus norvegicus BAC CH230-2K7 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q8C0V7",208,{"v":2E-55,"d":"2.00E-55"},"Putative sperm motility kinase W",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.",".",".",".",".","."]
["ENSRNOG00000021272",30,2.524058059,157,10.0998788,0.249909738,-2.000520979,{"v":3.36635E-16,"d":"3.37E-16"},{"v":7.91761e-16,"d":"7.92E-16"},"down","yes","Mcm8","protein_coding","chr3:120086763-120117008:+","gi|157816943|ref|NP_001099984.1|",4312,0,"DNA helicase MCM8 [Rattus norvegicus]","gi|157816942|ref|NM_001106514.1|",3226,0,"Rattus norvegicus minichromosome maintenance 8 homologous recombination repair factor (Mcm8), mRNA","D3ZVK1",1668,0,"DNA helicase MCM8","SSO0774",335,{"v":5e-100,"d":"5.00E-100"},"COG1241","pfam00493","MCM","MCM2/3/5 family.","GO:0000724|double-strand break repair via homologous recombination;GO:0006974|cellular response to DNA damage stimulus;GO:0007292|female gamete generation;GO:0032508|DNA duplex unwinding;GO:0036298|recombinational interstrand cross-link repair;GO:0048232|male gamete generation;GO:0050821|protein stabilization;GO:0071168|protein localization to chromatin;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005694|chromosome;GO:0005829|cytosol;GO:0042555|MCM complex;GO:0097362|MCM8-MCM9 complex;","GO:0003682|chromatin binding;GO:0003697|single-stranded DNA binding;GO:0005524|ATP binding;GO:0017116|single-stranded DNA-dependent ATP-dependent DNA helicase activity;GO:0019899|enzyme binding;GO:0032406|MutLbeta complex binding;GO:0032407|MutSalpha complex binding;GO:0032408|MutSbeta complex binding;","K10737","MCM8; DNA helicase MCM8 [EC:5.6.2.4]"]
["ENSRNOG00000007018",129,10.85344966,367,23.60927081,0.459711346,-1.121199823,{"v":3.87045e-16,"d":"3.87E-16"},{"v":9.07189e-16,"d":"9.07E-16"},"down","yes","Mapkbp1","protein_coding","chr3:106947827-106996199:+","gi|157819841|ref|NP_001102059.1|",7451,0,"mitogen-activated protein kinase-binding protein 1 [Rattus norvegicus]","gi|157819840|ref|NM_001108589.1|",4681,0,"Rattus norvegicus mitogen activated protein kinase binding protein 1 (Mapkbp1), mRNA","Q6NS57",2712,0,"Mitogen-activated protein kinase-binding protein 1",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.","GO:0016310|phosphorylation;GO:0032717|negative regulation of interleukin-8 production;GO:0043124|negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0046330|positive regulation of JNK cascade;GO:1900425|negative regulation of defense response to bacterium;","GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0097431|mitotic spindle pole;","GO:0016301|kinase activity;","K21763","MAPKBP1; mitogen-activated protein kinase binding protein 1"]
["ENSRNOG00000016689",109,9.170744282,328,21.10038372,0.434624526,-1.202158505,{"v":3.99873e-16,"d":"4.00E-16"},{"v":9.35244e-16,"d":"9.35E-16"},"down","yes","Fanci","protein_coding","chr1:133327297-133383640:+","gi|392337748|ref|XP_003753343.1|",6356,0,"PREDICTED: Fanconi anemia group I protein isoform X1 [Rattus norvegicus]","gi|672013877|ref|XM_003753295.3|",4383,0,"PREDICTED: Rattus norvegicus Fanconi anemia, complementation group I (Fanci), transcript variant X1, mRNA","Q8K368",2314,0,"Fanconi anemia group I protein homolog",".",".",".",".","pfam14678","FANCI_S4","FANCI solenoid 4. This is the solenoid 4 (S4) domain of the Fanconi anemia group I protein.","GO:0006281|DNA repair;GO:0008150|biological_process;GO:0031398|positive regulation of protein ubiquitination;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0003674|molecular_function;GO:0070182|DNA polymerase binding;","K10895","FANCI; fanconi anemia group I protein"]
["ENSRNOG00000053875",49,4.122628164,202,12.99474851,0.317253401,-1.656292464,{"v":4.16561e-16,"d":"4.17E-16"},{"v":9.72604e-16,"d":"9.73E-16"},"down","yes","Nacad","protein_coding","chr14:81465299-81473781:-","gi|695917192|ref|NP_001094125.2|",3344,0,"NAC-alpha domain-containing protein 1 [Rattus norvegicus]","gi|695917191|ref|NM_001100655.2|",2299,0,"Rattus norvegicus NAC alpha domain containing (Nacad), mRNA","Q5SWP3",1031,0,"NAC-alpha domain-containing protein 1","SPBC25H2.05",113,{"v":9e-27,"d":"9.00E-27"},"COG1308","pfam01849","NAC","NAC domain.","GO:0006612|protein targeting to membrane;","GO:0005737|cytoplasm;GO:0005854|nascent polypeptide-associated complex;","GO:0051082|unfolded protein binding;",".","."]
["ENSRNOG00000011167",163,13.71404879,430,27.66208842,0.49577055,-1.012255521,{"v":5.10303e-16,"d":"5.10E-16"},{"v":1.18588e-15,"d":"1.19E-15"},"down","yes","Wdhd1","protein_coding","chr15:20489291-20523096:-","gi|564385757|ref|XP_006251857.1|",5857,0,"PREDICTED: WD repeat and HMG-box DNA-binding protein 1 isoform X1 [Rattus norvegicus]","gi|672077517|ref|XM_006251795.2|",4220,0,"PREDICTED: Rattus norvegicus WD repeat and HMG-box DNA binding protein 1 (Wdhd1), transcript variant X1, mRNA","P59328",2033,0,"WD repeat and HMG-box DNA-binding protein 1",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.","GO:0000278|mitotic cell cycle;GO:0006261|DNA-dependent DNA replication;GO:0006281|DNA repair;GO:0006396|RNA processing;GO:0033044|regulation of chromosome organization;","GO:0000775|chromosome, centromeric region;GO:0005654|nucleoplasm;GO:0043596|nuclear replication fork;","GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003723|RNA binding;GO:0070063|RNA polymerase binding;","K11274","WDHD1, CTF4; chromosome transmission fidelity protein 4"]
["ENSRNOG00000000281",109,9.170744282,327,21.03605329,0.435953653,-1.197753326,{"v":5.38014e-16,"d":"5.38E-16"},{"v":1.24868E-15,"d":"1.25E-15"},"down","yes","Prodh1","protein_coding","chr11:82910137-82927305:+","gi|564377641|ref|XP_006248705.1|",2823,0,"PREDICTED: proline dehydrogenase 1, mitochondrial isoform X2 [Rattus norvegicus]","gi|564377640|ref|XM_006248643.1|",2121,0,"PREDICTED: Rattus norvegicus proline dehydrogenase (oxidase) 1 (Prodh), transcript variant X2, mRNA","Q9WU79",1004,0,"Proline dehydrogenase 1, mitochondrial","SPCC70.03c",118,{"v":3e-27,"d":"3.00E-27"},"COG0506","pfam01619","Pro_dh","Proline dehydrogenase.","GO:0010133|proline catabolic process to glutamate;GO:0010942|positive regulation of cell death;","GO:0005654|nucleoplasm;GO:0005739|mitochondrion;GO:0043231|intracellular membrane-bounded organelle;","GO:0004657|proline dehydrogenase activity;GO:0016597|amino acid binding;GO:0071949|FAD binding;","K00318","PRODH, fadM, putB; proline dehydrogenase [EC:1.5.5.2]"]
["ENSRNOG00000071170",85,7.151497835,278,17.88386182,0.399885545,-1.322340962,{"v":6.92552e-16,"d":"6.93E-16"},{"v":1.60053E-15,"d":"1.60E-15"},"down","yes","ENSRNOG00000071170","protein_coding","chr14:1406798-1433187:-","gi|293341562|ref|XP_002724970.1|",5010,0,"PREDICTED: GPI ethanolamine phosphate transferase 2 isoform X1 [Rattus norvegicus]","gi|672027597|ref|XM_002724924.4|",3398,0,"PREDICTED: Rattus norvegicus phosphatidylinositol glycan anchor biosynthesis, class G (Pigg), transcript variant X1, mRNA","Q5H8A4",1528,0,"GPI ethanolamine phosphate transferase 2","SPAC13G6.03",268,{"v":3e-75,"d":"3.00E-75"},"COG1524","pfam01663","Phosphodiest","Type I phosphodiesterase / nucleotide pyrophosphatase. This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyse the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars. Also in this family is ATX an autotaxin, tumor cell motility-stimulating protein which exhibits type I phosphodiesterases activity. The alignment encompasses the active site. Also present with in this family is 60-kDa Ca2+-ATPase form F. odoratum.",".",".",".",".","."]
["ENSRNOG00000005907",73,6.141874611,253,16.27560086,0.377366996,-1.405959841,{"v":7.05952E-16,"d":"7.06E-16"},{"v":1.62873e-15,"d":"1.63E-15"},"down","yes","Rad18","protein_coding","chr4:145735654-145821069:-","gi|117940025|ref|NP_001071141.1|",2195,0,"E3 ubiquitin-protein ligase RAD18 [Rattus norvegicus]","gi|126215805|gb|EF395817.1|",2252,0,"Rattus norvegicus RAD18 transcript variant (Rad18) mRNA, complete cds","Q9QXK2",747,0,"E3 ubiquitin-protein ligase RAD18","SPBC1734.06",84,{"v":2E-16,"d":"2.00E-16"},"COG5432","pfam13923","zf-C3HC4_2","Zinc finger, C3HC4 type (RING finger).","GO:0006301|postreplication repair;GO:0006513|protein monoubiquitination;GO:0006974|cellular response to DNA damage stimulus;GO:0007283|spermatogenesis;GO:0008150|biological_process;GO:0009411|response to UV;GO:0045910|negative regulation of DNA recombination;GO:0051865|protein autoubiquitination;GO:0051984|positive regulation of chromosome segregation;GO:0060548|negative regulation of cell death;","GO:0000785|chromatin;GO:0001741|XY body;GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005657|replication fork;GO:0005813|centrosome;GO:0016604|nuclear body;GO:0035861|site of double-strand break;GO:0042405|nuclear inclusion body;GO:0097505|Rad6-Rad18 complex;","GO:0000403|Y-form DNA binding;GO:0003674|molecular_function;GO:0003697|single-stranded DNA binding;GO:0031593|polyubiquitin modification-dependent protein binding;GO:0031625|ubiquitin protein ligase binding;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;","K10627","RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]"]
["ENSRNOG00000039494",6,0.504811612,85,5.468087246,0.092319597,-3.437219261,{"v":8.84378e-16,"d":"8.84E-16"},{"v":2.03349e-15,"d":"2.03E-15"},"down","yes","Aass","protein_coding","chr4:51606462-51663136:-","gi|155369281|ref|NP_001094433.1|",4813,0,"alpha-aminoadipic semialdehyde synthase, mitochondrial precursor [Rattus norvegicus]","gi|155369280|ref|NM_001100963.1|",3272,0,"Rattus norvegicus aminoadipate-semialdehyde synthase (Aass), mRNA","A2VCW9",1858,0,"Alpha-aminoadipic semialdehyde synthase, mitochondrial","YNR050c",322,{"v":8e-98,"d":"8.00E-98"},"COG1748","pfam03435","Saccharop_dh","Saccharopine dehydrogenase. This family comprised of three structural domains that can not be separated in the linear sequence. In some organisms this enzyme is found as a bifunctional polypeptide with lysine ketoglutarate reductase. The saccharopine dehydrogenase can also function as a saccharopine reductase.","GO:0008150|biological_process;GO:0019477|L-lysine catabolic process;GO:0019878|lysine biosynthetic process via aminoadipic acid;GO:0033512|L-lysine catabolic process to acetyl-CoA via saccharopine;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0043231|intracellular membrane-bounded organelle;","GO:0003674|molecular_function;GO:0004753|saccharopine dehydrogenase activity;GO:0047130|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity;GO:0047131|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity;","K14157","AASS; alpha-aminoadipic semialdehyde synthase [EC:1.5.1.8 1.5.1.9]"]
["ENSRNOG00000007662",83,6.983227298,272,17.49787919,0.399089925,-1.325214235,{"v":1.26859E-15,"d":"1.27E-15"},{"v":2.89371e-15,"d":"2.89E-15"},"down","yes","Zfp800","protein_coding","chr4:56826997-56849791:-","gi|672049251|ref|XP_008761034.1|",3217,0,"PREDICTED: zinc finger protein 800 isoform X2 [Rattus norvegicus]","gi|672049256|ref|XM_008762815.1|",2802,0,"PREDICTED: Rattus norvegicus zinc finger protein 800 (Zfp800), transcript variant X4, mRNA","Q0VEE6",1209,0,"Zinc finger protein 800",".",".",".",".","pfam13912","zf-C2H2_6","C2H2-type zinc finger.",".",".",".",".","."]
["ENSRNOG00000019208",117,9.843826432,339,21.80801854,0.451385641,-1.147567569,{"v":1.54501E-15,"d":"1.55E-15"},{"v":3.50953e-15,"d":"3.51E-15"},"down","yes","P2rx5","protein_coding","chr10:57777819-57789423:+","gi|149053319|gb|EDM05136.1|",2314,0,"purinergic receptor P2X, ligand-gated ion channel, 5 [Rattus norvegicus]","gi|31377507|ref|NM_080780.2|",2387,0,"Rattus norvegicus purinergic receptor P2X 5 (P2rx5), mRNA","P51578",893,0,"P2X purinoceptor 5",".",".",".",".","pfam00864","P2X_receptor","ATP P2X receptor.","GO:0006812|cation transport;GO:0009268|response to pH;GO:0010043|response to zinc ion;GO:0033198|response to ATP;GO:0035590|purinergic nucleotide receptor signaling pathway;GO:0043416|regulation of skeletal muscle tissue regeneration;GO:0048630|skeletal muscle tissue growth;GO:0051592|response to calcium ion;GO:0060079|excitatory postsynaptic potential;GO:0098655|cation transmembrane transport;GO:1905665|positive regulation of calcium ion import across plasma membrane;","GO:0005639|integral component of nuclear inner membrane;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0098794|postsynapse;","GO:0001614|purinergic nucleotide receptor activity;GO:0004931|extracellularly ATP-gated cation channel activity;GO:0005244|voltage-gated ion channel activity;GO:0005524|ATP binding;GO:0042802|identical protein binding;","K05219","P2RX5; P2X purinoceptor 5"]
["ENSRNOG00000027024",61,5.132251387,225,14.47434859,0.354575638,-1.495834679,{"v":1.57147e-15,"d":"1.57E-15"},{"v":3.56814e-15,"d":"3.57E-15"},"down","yes","Rgs16","protein_coding","chr13:65887530-65892857:+","gi|117606399|ref|NP_001071057.1|",947,{"v":3e-119,"d":"3.00E-119"},"regulator of G-protein signaling 16 [Rattus norvegicus]","gi|672074469|ref|XM_006250010.2|",2483,0,"PREDICTED: Rattus norvegicus regulator of G-protein signaling 16 (Rgs16), transcript variant X2, mRNA","P56700",366,{"v":1E-119,"d":"1.00E-119"},"Regulator of G-protein signaling 16",".",".",".",".","pfam00615","RGS","Regulator of G protein signaling domain. RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0009968|negative regulation of signal transduction;GO:0043547|positive regulation of GTPase activity;","GO:0005737|cytoplasm;GO:0031224|intrinsic component of membrane;GO:0045121|membrane raft;","GO:0005096|GTPase activator activity;","K16449","RGS; regulator of G-protein signaling"]
["ENSRNOG00000005853",25,2.103381716,140,9.006261346,0.2335466,-2.098217652,{"v":1.93205e-15,"d":"1.93E-15"},{"v":4.35238e-15,"d":"4.35E-15"},"down","yes","Tacr1","protein_coding","chr4:114920844-115089733:+","gi|6981628|ref|NP_036799.1|",2031,0,"substance-P receptor [Rattus norvegicus]","gi|155369728|ref|NM_012667.2|",3383,0,"Rattus norvegicus tachykinin receptor 1 (Tacr1), mRNA","P14600",781,0,"Substance-P receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0002118|aggressive behavior;GO:0002526|acute inflammatory response;GO:0002687|positive regulation of leukocyte migration;GO:0003051|angiotensin-mediated drinking behavior;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007217|tachykinin receptor signaling pathway;GO:0007218|neuropeptide signaling pathway;GO:0007611|learning or memory;GO:0007616|long-term memory;GO:0008217|regulation of blood pressure;GO:0008306|associative learning;GO:0009408|response to heat;GO:0009725|response to hormone;GO:0010193|response to ozone;GO:0010634|positive regulation of epithelial cell migration;GO:0010996|response to auditory stimulus;GO:0014070|response to organic cyclic compound;GO:0014910|regulation of smooth muscle cell migration;GO:0019233|sensory perception of pain;GO:0032224|positive regulation of synaptic transmission, cholinergic;GO:0032230|positive regulation of synaptic transmission, GABAergic;GO:0032355|response to estradiol;GO:0032570|response to progesterone;GO:0035094|response to nicotine;GO:0035106|operant conditioning;GO:0035815|positive regulation of renal sodium excretion;GO:0042713|sperm ejaculation;GO:0042755|eating behavior;GO:0043117|positive regulation of vascular permeability;GO:0043278|response to morphine;GO:0045471|response to ethanol;GO:0045760|positive regulation of action potential;GO:0045777|positive regulation of blood pressure;GO:0045778|positive regulation of ossification;GO:0045907|positive regulation of vasoconstriction;GO:0046878|positive regulation of saliva secretion;GO:0046887|positive regulation of hormone secretion;GO:0048265|response to pain;GO:0048266|behavioral response to pain;GO:0048660|regulation of smooth muscle cell proliferation;GO:0050671|positive regulation of lymphocyte proliferation;GO:0050679|positive regulation of epithelial cell proliferation;GO:0051496|positive regulation of stress fiber assembly;GO:0051602|response to electrical stimulus;GO:0060083|smooth muscle contraction involved in micturition;GO:0070472|regulation of uterine smooth muscle contraction;GO:0070474|positive regulation of uterine smooth muscle contraction;GO:1902093|positive regulation of flagellated sperm motility;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0036126|sperm flagellum;GO:0044297|cell body;GO:0061827|sperm head;GO:0071944|cell periphery;GO:0097225|sperm midpiece;","GO:0004995|tachykinin receptor activity;GO:0016496|substance P receptor activity;","K04222","TACR1; tachykinin receptor 1"]
["ENSRNOG00000057989",152,12.78856083,404,25.98949703,0.4920665,-1.023074795,{"v":2.20624e-15,"d":"2.21E-15"},{"v":4.96118e-15,"d":"4.96E-15"},"down","yes","Zp2","protein_coding","chr1:174513511-174525288:-","gi|149068078|gb|EDM17630.1|",3599,0,"zona pellucida glycoprotein 2, isoform CRA_b [Rattus norvegicus]","gi|13592142|ref|NM_031150.1|",2129,0,"Rattus norvegicus zona pellucida glycoprotein 2 (sperm receptor) (Zp2), mRNA","O54767",1388,0,"Zona pellucida sperm-binding protein 2",".",".",".",".","pfam00100","Zona_pellucida","Zona pellucida-like domain.","GO:0002455|humoral immune response mediated by circulating immunoglobulin;GO:0007339|binding of sperm to zona pellucida;GO:0060468|prevention of polyspermy;","GO:0005576|extracellular region;GO:0005771|multivesicular body;GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0016234|inclusion body;GO:0035805|egg coat;GO:0062023|collagen-containing extracellular matrix;","GO:0032190|acrosin binding;GO:0035804|structural constituent of egg coat;GO:0042802|identical protein binding;","K19927","ZP2; zona pellucida sperm-binding protein 2"]
["ENSRNOG00000063752",117,9.843826432,337,21.67935767,0.454064488,-1.139030887,{"v":2.73844E-15,"d":"2.74E-15"},{"v":6.12553E-15,"d":"6.13E-15"},"down","yes","Crocc2","protein_coding","chr9:93708684-93769402:+","gi|672066203|ref|XP_008765608.1|",6916,0,"PREDICTED: LOW QUALITY PROTEIN: putative ciliary rootlet coiled-coil protein-like 3 protein isoform X2 [Rattus norvegicus]","gi|672066202|ref|XM_008767386.1|",6494,0,"PREDICTED: Rattus norvegicus putative ciliary rootlet coiled-coil protein-like 3 protein-like (LOC102551034), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam15035","Rootletin","Ciliary rootlet component, centrosome cohesion.",".",".",".",".","."]
["ENSRNOG00000038330",75,6.310145148,253,16.27560086,0.387705818,-1.366965709,{"v":2.81435e-15,"d":"2.81E-15"},{"v":6.28536E-15,"d":"6.29E-15"},"down","yes","RGD1359508","protein_coding","chr2:124769940-124832449:+","gi|564336321|ref|XP_006232371.1|",602,{"v":8e-72,"d":"8.00E-72"},"PREDICTED: UPF0462 protein C4orf33 homolog isoform X2 [Rattus norvegicus]","gi|305410909|gb|AC241961.3|",854,0,"Rattus norvegicus Y Chr BAC RNECO-233P23 (Amplicon Express Rat SHR-Akr (EcoR1 Digest) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam02673","BacA","Bacitracin resistance protein BacA. Bacitracin resistance protein (BacA) is a putative undecaprenol kinase. BacA confers resistance to bacitracin, probably by phosphorylation of undecaprenol.",".",".",".",".","."]
["ENSRNOG00000006841",25,2.103381716,139,8.941930908,0.235226791,-2.087875708,{"v":2.96642e-15,"d":"2.97E-15"},{"v":6.61413e-15,"d":"6.61E-15"},"down","yes","Ano4","protein_coding","chr7:23329070-23738434:-","gi|568967784|ref|XP_006513818.1|",5729,0,"PREDICTED: anoctamin-4 isoform X2 [Mus musculus]","gi|755534677|ref|XM_006513755.2|",3859,0,"PREDICTED: Mus musculus anoctamin 4 (Ano4), transcript variant X1, mRNA","Q8C5H1",1915,0,"Anoctamin-4",".",".",".",".","pfam04547","Anoctamin","Calcium-activated chloride channel. The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.","GO:0006821|chloride transport;GO:0055085|transmembrane transport;GO:0061589|calcium activated phosphatidylserine scrambling;GO:0061590|calcium activated phosphatidylcholine scrambling;GO:0061591|calcium activated galactosylceramide scrambling;GO:1902476|chloride transmembrane transport;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0005229|intracellular calcium activated chloride channel activity;GO:0005254|chloride channel activity;GO:0017128|phospholipid scramblase activity;GO:0046983|protein dimerization activity;","K19499","ANO4, TMEM16D; anoctamin-4"]
["ENSRNOG00000070376",23,1.935111179,132,8.49161784,0.227884864,-2.133622989,{"v":6.3159e-15,"d":"6.32E-15"},{"v":1.3825E-14,"d":"1.38E-14"},"down","yes","ENSRNOG00000070376","lncRNA","chr19:19550144-19608206:-","gi|149032645|gb|EDL87515.1|",161,{"v":7e-10,"d":"7.00E-10"},"rCG44317, partial [Rattus norvegicus]","gi|672084529|ref|XR_597164.1|",6658,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102550863 (LOC102550863), transcript variant X3, ncRNA",".",".",".",".",".",".",".",".","pfam14972","Mito_morph_reg","Mitochondrial morphogenesis regulator. This family of proteins regulate mitochondrial morphogenesis via a mechanism which is independent of mitofusins and dynamin-related protein 1.",".",".",".",".","."]
["ENSRNOG00000054286",81,6.81495676,262,16.8545748,0.404338694,-1.306363824,{"v":8.30214e-15,"d":"8.30E-15"},{"v":1.81033e-14,"d":"1.81E-14"},"down","yes","Rrm2","protein_coding","chr6:41340557-41346773:+","gi|71043760|ref|NP_001020911.1|",1900,0,"ribonucleoside-diphosphate reductase subunit M2 [Rattus norvegicus]","gi|71043759|ref|NM_001025740.1|",2473,0,"Rattus norvegicus ribonucleotide reductase regulatory subunit M2 (Rrm2), mRNA","Q4KLN6",736,0,"Ribonucleoside-diphosphate reductase subunit M2","YJL026w",430,{"v":2e-141,"d":"2.00E-141"},"COG0208","pfam00268","Ribonuc_red_sm","Ribonucleotide reductase, small chain.","GO:0000278|mitotic cell cycle;GO:0001824|blastocyst development;GO:0006206|pyrimidine nucleobase metabolic process;GO:0006260|DNA replication;GO:0008284|positive regulation of cell proliferation;GO:0009262|deoxyribonucleotide metabolic process;GO:0009263|deoxyribonucleotide biosynthetic process;GO:0051290|protein heterotetramerization;","GO:0005635|nuclear envelope;GO:0005829|cytosol;GO:0005971|ribonucleoside-diphosphate reductase complex;","GO:0003674|molecular_function;GO:0004748|ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor;GO:0008199|ferric iron binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;","K10808","RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]"]
["ENSRNOG00000032813",136,11.44239654,369,23.73793169,0.482030056,-1.05280499,{"v":8.62433e-15,"d":"8.62E-15"},{"v":1.87758e-14,"d":"1.88E-14"},"down","yes","Mdc1","protein_coding","chr20:2895505-2910240:-","gi|569000267|ref|XP_006524327.1|",5504,0,"PREDICTED: mediator of DNA damage checkpoint protein 1 isoform X4 [Mus musculus]","gi|755556662|ref|XM_006524264.2|",3194,0,"PREDICTED: Mus musculus mediator of DNA damage checkpoint 1 (Mdc1), transcript variant X6, mRNA","Q5U2M8",1668,0,"Mediator of DNA damage checkpoint protein 1",".",".",".",".","pfam05109","Herpes_BLLF1","Herpes virus major outer envelope glycoprotein (BLLF1). This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralizing antibodies in vivo.","GO:0006281|DNA repair;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005694|chromosome;GO:0005925|focal adhesion;GO:0016604|nuclear body;","GO:0003674|molecular_function;GO:0008022|protein C-terminus binding;GO:0070975|FHA domain binding;","K20780","MDC1; mediator of DNA damage checkpoint protein 1"]
["ENSRNOG00000020906",124,10.43277331,346,22.25833161,0.468713176,-1.093222743,{"v":9.45824e-15,"d":"9.46E-15"},{"v":2.05583E-14,"d":"2.06E-14"},"down","yes","Pola2","protein_coding","chr1:203203388-203251348:-","gi|149062123|gb|EDM12546.1|",2913,0,"polymerase (DNA directed), alpha 2, isoform CRA_a [Rattus norvegicus]","gi|67514565|ref|NM_053480.2|",2257,0,"Rattus norvegicus polymerase (DNA directed), alpha 2, accessory subunit (Pola2), mRNA","O89043",1121,0,"DNA polymerase alpha subunit B","SPCC553.09c",179,{"v":4e-47,"d":"4.00E-47"},"COG5214","pfam04042","DNA_pol_E_B","DNA polymerase alpha/epsilon subunit B. This family contains a number of DNA polymerase subunits.  The B subunit of the DNA polymerase alpha plays an essential role at the initial stage of DNA replication in S. cerevisiae and is phosphorylated in a cell cycle-dependent manner. DNA polymerase epsilon is essential for cell viability and chromosomal DNA replication in budding yeast. In addition, DNA polymerase epsilon may be involved in DNA repair and cell-cycle checkpoint control. The enzyme consists of at least four subunits in mammalian cells as well as in yeast. The largest subunit of DNA polymerase epsilon is responsible for polymerase epsilon is responsible for polymerase activity. In mouse, the DNA polymerase epsilon subunit B is the second largest subunit of the DNA polymerase. A part of the N-terminal was found to be responsible for the interaction with SAP18. Experimental evidence suggests that this subunit may recruit histone deacetylase to the replication fork to modify the chromatin structure.","GO:0006260|DNA replication;GO:0006269|DNA replication, synthesis of RNA primer;GO:0006270|DNA replication initiation;GO:0006606|protein import into nucleus;GO:0071897|DNA biosynthetic process;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005658|alpha DNA polymerase:primase complex;GO:0005829|cytosol;","GO:0003677|DNA binding;GO:0003887|DNA-directed DNA polymerase activity;","K02321","POLA2; DNA polymerase alpha subunit B"]
["ENSRNOG00000018379",72,6.057739343,243,15.63229648,0.387514359,-1.367678327,{"v":9.61302e-15,"d":"9.61E-15"},{"v":2.08864e-14,"d":"2.09E-14"},"down","yes","Zfp688","protein_coding","chr1:182039931-182043103:-","gi|149067734|gb|EDM17286.1|",1096,{"v":1e-145,"d":"1.00E-145"},"zinc finger protein 688 (predicted), isoform CRA_b [Rattus norvegicus]","gi|20380697|gb|BC027683.1|",953,0,"Mus musculus zinc finger protein 688, mRNA (cDNA clone MGC:41678 IMAGE:1345974), complete cds","P0C7X2",259,{"v":4e-81,"d":"4.00E-81"},"Zinc finger protein 688",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSRNOG00000019059",93,7.824579984,285,18.33417488,0.426775682,-1.228450123,{"v":1.19042E-14,"d":"1.19E-14"},{"v":2.57413e-14,"d":"2.57E-14"},"down","yes","Zfp1","protein_coding","chr19:39599954-39632995:+","gi|672031309|ref|XP_008772462.1|",2585,0,"PREDICTED: zinc finger protein 1 homolog isoform X1 [Rattus norvegicus]","gi|672031312|ref|XM_008774242.1|",2185,0,"PREDICTED: Rattus norvegicus zinc finger protein 1 (Zfp1), transcript variant X3, mRNA","P08042",767,0,"Zinc finger protein 1",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006357|regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0046872|metal ion binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSRNOG00000004585",37,3.11300494,165,10.6145223,0.293277912,-1.769659674,{"v":1.34534E-14,"d":"1.35E-14"},{"v":2.90221E-14,"d":"2.90E-14"},"down","yes","Tmtc2","protein_coding","chr7:40394220-40807298:-","gi|330340424|ref|NP_001164648.2|",3839,0,"transmembrane and TPR repeat-containing protein 2 precursor [Rattus norvegicus]","gi|755534631|ref|XR_380404.2|",2503,0,"PREDICTED: Mus musculus transmembrane and tetratricopeptide repeat containing 2 (Tmtc2), transcript variant X1, misc_RNA","Q56A06",1452,0,"Transmembrane and TPR repeat-containing protein 2",".",".",".",".","pfam08409","DUF1736","Domain of unknown function (DUF1736). This domain of unknown function is found in various hypothetical metazoan proteins.","GO:0008150|biological_process;GO:0035269|protein O-linked mannosylation;GO:0055074|calcium ion homeostasis;","GO:0005575|cellular_component;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0000030|mannosyltransferase activity;GO:0003674|molecular_function;GO:0004169|dolichyl-phosphate-mannose-protein mannosyltransferase activity;","K23424","TMTC; protein O-mannosyl-transferase [EC:2.4.1.-]"]
["ENSRNOG00000024008",65,5.468792462,227,14.60300947,0.374497632,-1.4169715,{"v":1.48538e-14,"d":"1.49E-14"},{"v":3.19166e-14,"d":"3.19E-14"},"down","yes","Cdc25c","protein_coding","chr18:26335834-26356185:-","gi|564393060|ref|XP_006254641.1|",2351,0,"PREDICTED: M-phase inducer phosphatase 3 isoform X1 [Rattus norvegicus]","gi|672083039|ref|XM_008772039.1|",1620,0,"PREDICTED: Rattus norvegicus cell division cycle 25C (Cdc25c), transcript variant X2, mRNA","P48967",763,0,"M-phase inducer phosphatase 3","SPAC24H6.05",137,{"v":2e-33,"d":"2.00E-33"},"COG5105","pfam06617","M-inducer_phosp","M-phase inducer phosphatase. This family represents a region within eukaryotic M-phase inducer phosphatases (EC:3.1.3.48), which also contain the pfam00581 domain. These proteins are involved in the control of mitosis.","GO:0000086|G2/M transition of mitotic cell cycle;GO:0007283|spermatogenesis;GO:0010971|positive regulation of G2/M transition of mitotic cell cycle;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0051301|cell division;GO:0110032|positive regulation of G2/MI transition of meiotic cell cycle;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005758|mitochondrial intermembrane space;GO:0016607|nuclear speck;GO:0048471|perinuclear region of cytoplasm;","GO:0004725|protein tyrosine phosphatase activity;GO:0005515|protein binding;GO:0019901|protein kinase binding;GO:0050699|WW domain binding;","K05867","CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]"]
["ENSRNOG00000019065",113,9.507285357,322,20.7144011,0.45896984,-1.123528741,{"v":2.17598e-14,"d":"2.18E-14"},{"v":4.64622E-14,"d":"4.65E-14"},"down","yes","Zfp385b","protein_coding","chr3:62355196-62640510:-","gi|157819921|ref|NP_001101206.1|",1842,0,"zinc finger protein 385B [Rattus norvegicus]","gi|157819920|ref|NM_001107736.1|",3789,0,"Rattus norvegicus zinc finger protein 385B (Zfp385b), mRNA","Q8BXJ8",681,0,"Zinc finger protein 385B",".",".",".",".","pfam12874","zf-met","Zinc-finger of C2H2 type. This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.","GO:0072332|intrinsic apoptotic signaling pathway by p53 class mediator;","GO:0005634|nucleus;","GO:0002039|p53 binding;GO:0003676|nucleic acid binding;GO:0008270|zinc ion binding;",".","."]
["ENSRNOG00000019447",2,0.168270537,64,4.117148044,0.040870655,-4.612790825,{"v":2.1922e-14,"d":"2.19E-14"},{"v":4.67903e-14,"d":"4.68E-14"},"down","yes","Ecel1","protein_coding","chr9:87816718-87826675:-","gi|148708241|gb|EDL40188.1|",3882,0,"endothelin converting enzyme-like 1, isoform CRA_a, partial [Mus musculus]","gi|564369656|ref|XM_006245475.1|",3289,0,"PREDICTED: Rattus norvegicus endothelin converting enzyme-like 1 (Ecel1), transcript variant X1, mRNA","Q9JHL3",1484,0,"Endothelin-converting enzyme-like 1","MA2001",329,{"v":1e-95,"d":"1.00E-95"},"COG3590","pfam05649","Peptidase_M13_N","Peptidase family M13. M13 peptidases are well-studied proteases found in a wide range of organisms including mammals and bacteria. In mammals they participate in processes such as cardiovascular development, blood-pressure regulation, nervous control of respiration, and regulation of the function of neuropeptides in the central nervous system. In bacteria they may be used for digestion of milk.","GO:0003016|respiratory system process;GO:0006508|proteolysis;GO:0007218|neuropeptide signaling pathway;GO:0016485|protein processing;GO:0035556|intracellular signal transduction;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004222|metalloendopeptidase activity;GO:0046872|metal ion binding;","K09610","ECEL1; endothelin-converting enzyme-like 1 [EC:3.4.24.-]"]
["ENSRNOG00000054935",20,1.682705373,121,7.78398302,0.216175365,-2.209725968,{"v":2.33847E-14,"d":"2.34E-14"},{"v":4.98146e-14,"d":"4.98E-14"},"down","yes","AC119007.4","lncRNA","chr7:132408978-132413672:+","gi|149031988|gb|EDL86900.1|",392,{"v":2E-41,"d":"2.00E-41"},"rCG50756, partial [Rattus norvegicus]","gi|672022400|ref|XR_602000.1|",1987,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103692985 (LOC103692985), ncRNA",".",".",".",".",".",".",".",".","pfam15091","DUF4554","Domain of unknown function (DUF4554). This family of proteins is functionally uncharacterized. This family of proteins is found in some vertebrates. This family includes human protein C11orf80.",".",".",".",".","."]
["ENSRNOG00000065255",13,1.093758492,101,6.497374257,0.168338539,-2.57056259,{"v":2.57151e-14,"d":"2.57E-14"},{"v":5.4672e-14,"d":"5.47E-14"},"down","yes","Gsg1l","protein_coding","chr1:180442630-180654134:-","gi|442580958|sp|D3ZK93.1|GSG1L_RAT",1442,0,"RecName: Full=Germ cell-specific gene 1-like protein; Short=GSG1-like protein","gi|672038614|ref|XM_008759923.1|",1402,0,"PREDICTED: Rattus norvegicus GSG1-like (Gsg1l), transcript variant X2, mRNA","D3ZK93",560,0,"Germ cell-specific gene 1-like protein",".",".",".",".","pfam07803","GSG-1","GSG1-like protein. This family contains sequences bearing similarity to a region of GSG1, a protein specifically expressed in testicular germ cells. It is possible that overexpression of the human homolog may be involved in tumorigenesis of human testicular germ cell tumors. The region in question has four highly-conserved cysteine residues.",".",".",".",".","."]
["ENSRNOG00000012051",145,12.19961395,381,24.50989695,0.49774236,-1.006528923,{"v":3.02215e-14,"d":"3.02E-14"},{"v":6.40277e-14,"d":"6.40E-14"},"down","yes","Ncaph","protein_coding","chr3:114371941-114399180:-","gi|149023207|gb|EDL80101.1|",3534,0,"rCG26612 [Rattus norvegicus]","gi|672017307|ref|XR_085785.4|",2684,0,"PREDICTED: Rattus norvegicus non-SMC condensin I complex, subunit H (Ncaph), transcript variant X1, misc_RNA","Q8C156",1219,0,"Condensin complex subunit 2","SPCC306.03c",155,{"v":2e-38,"d":"2.00E-38"},"COG5229","pfam05786","Cnd2","Condensin complex subunit 2. This family consists of several Barren protein homologues from several eukaryotic organisms. In Drosophila Barren (barr) is required for sister-chromatid segregation in mitosis. barr encodes a novel protein that is present in proliferating cells and has homologues in yeast and human. Mitotic defects in barr embryos become apparent during cycle 16, resulting in a loss of PNS and CNS neurons. Centromeres move apart at the metaphase-anaphase transition and Cyclin B is degraded, but sister chromatids remain connected, resulting in chromatin bridging. Barren protein localizes to chromatin throughout mitosis. Colocalisation and biochemical experiments indicate that Barren associates with Topoisomerase II throughout mitosis and alters the activity of Topoisomerase II. It has been suggested that this association is required for proper chromosomal segregation by facilitating the decatenation of chromatids at anaphase. This family forms one of the three non-structural maintenance of chromosomes (SMC) subunits of the mitotic condensation complex along with Cnd1 and Cnd3.","GO:0007076|mitotic chromosome condensation;GO:0007143|female meiotic nuclear division;GO:0010032|meiotic chromosome condensation;GO:0045132|meiotic chromosome segregation;GO:0051301|cell division;GO:0051309|female meiosis chromosome separation;","GO:0000796|condensin complex;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005694|chromosome;GO:0005829|cytosol;","GO:0003682|chromatin binding;",".","."]
["ENSRNOG00000017593",108,9.086609014,311,20.00676628,0.454176796,-1.138674093,{"v":3.21353e-14,"d":"3.21E-14"},{"v":6.80295e-14,"d":"6.80E-14"},"down","yes","Mtr","protein_coding","chr17:58220071-58304822:+","gi|149055327|gb|EDM06981.1|",6577,0,"5-methyltetrahydrofolate-homocysteine methyltransferase, isoform CRA_b [Rattus norvegicus]","gi|13540690|ref|NM_030864.1|",4451,0,"Rattus norvegicus 5-methyltetrahydrofolate-homocysteine methyltransferase (Mtr), mRNA","Q9Z2Q4",2534,0,"Methionine synthase","AGc3907_2",1031,0,"COG1410","pfam02574","S-methyl_trans","Homocysteine S-methyltransferase. This is a family of related homocysteine S-methyltransferases enzymes: 5-methyltetrahydrofolate--homocysteine S-methyltransferases also known EC:2.1.1.13; Betaine--homocysteine S-methyltransferase (vitamin B12 dependent), EC:2.1.1.5,; and Homocysteine S-methyltransferase, EC:2.1.1.10,.","GO:0006306|DNA methylation;GO:0006479|protein methylation;GO:0006555|methionine metabolic process;GO:0009086|methionine biosynthetic process;GO:0009235|cobalamin metabolic process;GO:0031103|axon regeneration;GO:0042558|pteridine-containing compound metabolic process;GO:0046653|tetrahydrofolate metabolic process;GO:0048678|response to axon injury;GO:0050667|homocysteine metabolic process;GO:0061431|cellular response to methionine;GO:0071732|cellular response to nitric oxide;","GO:0005575|cellular_component;GO:0005829|cytosol;","GO:0005542|folic acid binding;GO:0008168|methyltransferase activity;GO:0008270|zinc ion binding;GO:0008705|methionine synthase activity;GO:0016597|amino acid binding;GO:0031419|cobalamin binding;","K00548","metH, MTR; 5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13]"]
["ENSRNOG00000009439",15,1.26202903,106,6.819026448,0.185074664,-2.433820684,{"v":3.83242e-14,"d":"3.83E-14"},{"v":8.08796e-14,"d":"8.09E-14"},"down","yes","Eef1a1","protein_coding","chr8:79341557-79344839:-","gi|965955645|ref|XP_014953624.1|",2167,0,"PREDICTED: elongation factor 1-alpha 1-like [Ovis aries]","gi|118764357|gb|BC128723.1|",1341,0,"Rattus norvegicus eukaryotic translation elongation factor 1 alpha 1, mRNA (cDNA clone MGC:156575 IMAGE:7312569), complete cds","P62630",800,0,"Elongation factor 1-alpha 1","SPCC794.09c",662,0,"COG5256","pfam00009","GTP_EFTU","Elongation factor Tu GTP binding domain. This domain contains a P-loop motif, also found in several other families such as pfam00071, pfam00025 and pfam00063. Elongation factor Tu consists of three structural domains, this plus two C-terminal beta barrel domains.","GO:0006412|translation;GO:0006414|translational elongation;GO:0007568|aging;GO:0010942|positive regulation of cell death;GO:0010976|positive regulation of neuron projection development;GO:0071364|cellular response to epidermal growth factor stimulus;GO:0071466|cellular response to xenobiotic stimulus;GO:1900022|regulation of D-erythro-sphingosine kinase activity;GO:1903427|negative regulation of reactive oxygen species biosynthetic process;GO:1990090|cellular response to nerve growth factor stimulus;","GO:0005634|nucleus;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005765|lysosomal membrane;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0030864|cortical actin cytoskeleton;GO:0032587|ruffle membrane;","GO:0000049|tRNA binding;GO:0003729|mRNA binding;GO:0003746|translation elongation factor activity;GO:0003924|GTPase activity;GO:0005516|calmodulin binding;GO:0005525|GTP binding;GO:0019900|kinase binding;GO:0019901|protein kinase binding;GO:0042802|identical protein binding;GO:1901363|heterocyclic compound binding;","K03231","EEF1A; elongation factor 1-alpha"]
["ENSRNOG00000014652",11,0.925487955,94,6.047061189,0.153047559,-2.707948058,{"v":4.0258e-14,"d":"4.03E-14"},{"v":8.48292e-14,"d":"8.48E-14"},"down","yes","Aqp8","protein_coding","chr1:177993305-177999158:+","gi|564330829|ref|XP_006230249.1|",1239,{"v":3e-166,"d":"3.00E-166"},"PREDICTED: aquaporin-8 isoform X1 [Rattus norvegicus]","gi|672037739|ref|XM_006230187.2|",1512,0,"PREDICTED: Rattus norvegicus aquaporin 8 (Aqp8), transcript variant X1, mRNA","P56405",477,{"v":7e-166,"d":"7.00E-166"},"Aquaporin-8","SMc01870",73.9,{"v":5e-14,"d":"5.00E-14"},"COG0580","pfam00230","MIP","Major intrinsic protein. MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.","GO:0006833|water transport;GO:0015722|canalicular bile acid transport;GO:0055085|transmembrane transport;GO:0071320|cellular response to cAMP;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0045177|apical part of cell;GO:0046691|intracellular canaliculus;GO:0046930|pore complex;","GO:0015250|water channel activity;GO:0015288|porin activity;","K09869","AQP8; aquaporin-8"]
["ENSRNOG00000069756",59,4.96398085,211,13.57372246,0.365705197,-1.451246965,{"v":4.44671e-14,"d":"4.45E-14"},{"v":9.34812e-14,"d":"9.35E-14"},"down","yes","Ccdc92b","protein_coding","chr10:59479743-59501495:+","gi|62000658|ref|NP_001013806.1|",742,{"v":1e-85,"d":"1.00E-85"},"uncharacterized protein LOC432582 [Mus musculus]","gi|672068321|ref|XM_008767929.1|",2934,0,"PREDICTED: Rattus norvegicus similar to novel protein (RGD1562276), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam14916","CCDC92","Coiled-coil domain of unknown function. This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The function is not known and the proteins carry no other domains.",".",".",".",".","."]
["ENSRNOG00000016640",103,8.665932671,300,19.29913146,0.449032263,-1.155108989,{"v":4.69725e-14,"d":"4.70E-14"},{"v":9.8596e-14,"d":"9.86E-14"},"down","yes","Dner","protein_coding","chr9:85586987-85902637:-","gi|149016288|gb|EDL75534.1|",3605,0,"rCG23980, isoform CRA_a [Rattus norvegicus]","gi|672024220|ref|XM_008758063.1|",2892,0,"PREDICTED: Rattus norvegicus delta/notch-like EGF repeat containing (Dner), transcript variant X1, mRNA","Q8JZM4",1358,0,"Delta and Notch-like epidermal growth factor-related receptor",".",".",".",".","pfam06247","Plasmod_Pvs28","Plasmodium ookinete surface protein Pvs28. This family consists of several ookinete surface protein (Pvs28) from several species of Plasmodium. Pvs25 and Pvs28 are expressed on the surface of ookinetes. These proteins are potential candidates for vaccine and induce antibodies that block the infectivity of Plasmodium vivax in immunised animals.","GO:0007220|Notch receptor processing;GO:0007417|central nervous system development;GO:0010001|glial cell differentiation;GO:0048741|skeletal muscle fiber development;","GO:0005769|early endosome;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0043025|neuronal cell body;","GO:0005112|Notch binding;GO:0005509|calcium ion binding;","K24463","DNER; delta and Notch-like epidermal growth factor-related receptor"]
["ENSRNOG00000010736",16,1.346164298,108,6.947687324,0.193757179,-2.367678327,{"v":5.66091e-14,"d":"5.66E-14"},{"v":1.18185e-13,"d":"1.18E-13"},"down","yes","Pbx4","protein_coding","chr16:19555090-19590014:-","gi|157822083|ref|NP_001101869.1|",1821,0,"pre-B-cell leukemia transcription factor 4 [Rattus norvegicus]","gi|157822082|ref|NM_001108399.1|",1384,0,"Rattus norvegicus pre-B-cell leukemia homeobox 4 (Pbx4), mRNA","Q99NE9",632,0,"Pre-B-cell leukemia transcription factor 4",".",".",".",".","pfam03792","PBC","PBC domain. The PBC domain is a member of the TALE (three-amino-acid loop extension) superclass of homeodomain proteins.","GO:0001654|eye development;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007420|brain development;GO:0009887|animal organ morphogenesis;GO:0048568|embryonic organ development;GO:0048666|neuron development;","GO:0001741|XY body;GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565|sequence-specific DNA binding;","K15611","PBX4; pre-B-cell leukemia transcription factor 4"]
["ENSRNOG00000048256",59,4.96398085,210,13.50939202,0.367446651,-1.444393294,{"v":6.25381e-14,"d":"6.25E-14"},{"v":1.30065e-13,"d":"1.30E-13"},"down","yes","Fhip1a","protein_coding","chr2:171021246-171265848:-","gi|158341634|ref|NP_766270.2|",4650,0,"protein FAM160A1 [Mus musculus]","gi|197384719|ref|NM_001134592.1|",2851,0,"Rattus norvegicus family with sequence similarity 160, member A1 (Fam160a1), mRNA",".",".",".",".",".",".",".",".","pfam10257","RAI16-like","Retinoic acid induced 16-like protein. This is the conserved N-terminal 450 residues of a family of proteins described as retinoic acid-induced protein 16-like proteins. The exact function is not known. The proteins are found from worms to humans.","GO:1905719|protein localization to perinuclear region of cytoplasm;",".",".",".","."]
["ENSRNOG00000059984",52,4.37503397,194,12.48010501,0.35056067,-1.512263949,{"v":8.53845e-14,"d":"8.54E-14"},{"v":1.75834e-13,"d":"1.76E-13"},"down","yes","Dll1","protein_coding","chr1:56312066-56320179:-","gi|149047105|gb|EDL99825.1|",3580,0,"delta-like 1 (Drosophila) [Rattus norvegicus]","gi|330417869|ref|NM_032063.2|",3034,0,"Rattus norvegicus delta-like 1 (Drosophila) (Dll1), mRNA","P97677",1379,0,"Delta-like protein 1",".",".",".",".","pfam07657","MNNL","N terminus of Notch ligand. This entry represents a region of conserved sequence at the N terminus of several Notch ligand proteins.","GO:0001709|cell fate determination;GO:0001756|somitogenesis;GO:0001757|somite specification;GO:0001947|heart looping;GO:0002315|marginal zone B cell differentiation;GO:0003323|type B pancreatic cell development;GO:0007219|Notch signaling pathway;GO:0007267|cell-cell signaling;GO:0007368|determination of left/right symmetry;GO:0007386|compartment pattern specification;GO:0007399|nervous system development;GO:0008217|regulation of blood pressure;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0009912|auditory receptor cell fate commitment;GO:0009954|proximal/distal pattern formation;GO:0010628|positive regulation of gene expression;GO:0014002|astrocyte development;GO:0014807|regulation of somitogenesis;GO:0021510|spinal cord development;GO:0021688|cerebellar molecular layer formation;GO:0021693|cerebellar Purkinje cell layer structural organization;GO:0030155|regulation of cell adhesion;GO:0030857|negative regulation of epithelial cell differentiation;GO:0032693|negative regulation of interleukin-10 production;GO:0034351|negative regulation of glial cell apoptotic process;GO:0035265|organ growth;GO:0040008|regulation of growth;GO:0045596|negative regulation of cell differentiation;GO:0045605|negative regulation of epidermal cell differentiation;GO:0045608|negative regulation of inner ear auditory receptor cell differentiation;GO:0045638|negative regulation of myeloid cell differentiation;GO:0045662|negative regulation of myoblast differentiation;GO:0045665|negative regulation of neuron differentiation;GO:0045746|negative regulation of Notch signaling pathway;GO:0045747|positive regulation of Notch signaling pathway;GO:0045807|positive regulation of endocytosis;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046331|lateral inhibition;GO:0048630|skeletal muscle tissue growth;GO:0048631|regulation of skeletal muscle tissue growth;GO:0048633|positive regulation of skeletal muscle tissue growth;GO:0048665|neuron fate specification;GO:0048839|inner ear development;GO:0050767|regulation of neurogenesis;GO:0051302|regulation of cell division;GO:0060041|retina development in camera-type eye;GO:0060042|retina morphogenesis in camera-type eye;GO:0060853|Notch signaling pathway involved in arterial endothelial cell fate commitment;GO:0070986|left/right axis specification;GO:0072006|nephron development;GO:0072014|proximal tubule development;GO:0072070|loop of Henle development;GO:0072583|clathrin-dependent endocytosis;GO:0097009|energy homeostasis;GO:0097102|endothelial tip cell fate specification;GO:0097150|neuronal stem cell population maintenance;GO:0098773|skin epidermis development;GO:1900746|regulation of vascular endothelial growth factor signaling pathway;GO:1903672|positive regulation of sprouting angiogenesis;GO:2000726|negative regulation of cardiac muscle cell differentiation;","GO:0005886|plasma membrane;GO:0005912|adherens junction;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0031410|cytoplasmic vesicle;GO:0045121|membrane raft;","GO:0005112|Notch binding;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0030957|Tat protein binding;GO:0097110|scaffold protein binding;","K06051","DLL; delta"]
["ENSRNOG00000028910",101,8.497662133,294,18.91314883,0.449299173,-1.154251687,{"v":8.66183e-14,"d":"8.66E-14"},{"v":1.78173E-13,"d":"1.78E-13"},"down","yes","Ccdc9b","protein_coding","chr3:105739174-105744697:-","gi|155029554|ref|NP_001001982.2|",2200,0,"uncharacterized protein C15orf52 homolog [Mus musculus]","gi|564302149|ref|XR_085782.2|",1766,0,"PREDICTED: Rattus norvegicus similar to hypothetical protein (RGD1565536), misc_RNA",".",".",".",".",".",".",".",".","pfam15266","DUF4594","Domain of unknown function (DUF4594). This protein family is a domain of unknown function. The protein family is found in eukaryotes, and is typically between 170 and 183 amino acids in length.In humans, the gene encoding this protein lies in the position, chromosome 15 open reading frame 52.",".",".",".",".","."]
["ENSRNOG00000007906",112,9.423150088,315,20.26408803,0.46501723,-1.104643922,{"v":9.08122e-14,"d":"9.08E-14"},{"v":1.86447e-13,"d":"1.86E-13"},"down","yes","Bub1b","protein_coding","chr3:105563138-105615547:+","gi|747165376|ref|NP_612549.1|",5379,0,"mitotic checkpoint serine/threonine-protein kinase BUB1 beta [Rattus norvegicus]","gi|747165375|ref|NM_138540.1|",4382,0,"Rattus norvegicus BUB1 mitotic checkpoint serine/threonine kinase B (Bub1b), mRNA","Q9Z1S0",1787,0,"Mitotic checkpoint serine/threonine-protein kinase BUB1 beta",".",".",".",".","pfam08311","Mad3_BUB1_I","Mad3/BUB1 homology region 1. Proteins containing this domain are checkpoint proteins involved in cell division. This region has been shown to be essential for the binding of the binding of BUB1 and MAD3 to CDC20p.","GO:0006468|protein phosphorylation;GO:0007091|metaphase/anaphase transition of mitotic cell cycle;GO:0007094|mitotic spindle assembly checkpoint;GO:0008150|biological_process;GO:0051754|meiotic sister chromatid cohesion, centromeric;GO:0071459|protein localization to chromosome, centromeric region;","GO:0000776|kinetochore;GO:0000940|condensed chromosome outer kinetochore;GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005819|spindle;GO:0005829|cytosol;GO:0048471|perinuclear region of cytoplasm;","GO:0003674|molecular_function;GO:0004672|protein kinase activity;GO:0005524|ATP binding;","K06637","BUB1B, BUBR1, MAD3L; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [EC:2.7.11.1]"]
["ENSRNOG00000032846",89,7.48803891,270,17.36921831,0.431109724,-1.213872991,{"v":1.0002E-13,"d":"1.00E-13"},{"v":2.04657e-13,"d":"2.05E-13"},"down","yes","Cdpf1","protein_coding","chr7:116901003-116905406:-","gi|194733721|ref|NP_001124168.1|",855,{"v":1e-110,"d":"1.00E-110"},"cysteine-rich DPF motif domain-containing protein 1 [Rattus norvegicus]","gi|564361382|ref|XM_006242163.1|",908,0,"PREDICTED: Rattus norvegicus similar to 2210021J22Rik protein (RGD1306001), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam10170","C6_DPF","Cysteine-rich domain. This is the N-terminal approximately 100 amino acids of a family of proteins found from nematodes to humans. It contains between six and eight highly conserved cysteine residues and a characteristic DPF sequence motif. One member is putatively named as receptor for egg jelly protein but this could not confirmed.",".",".",".",".","."]
["ENSRNOG00000006996",105,8.834203208,301,19.36346189,0.456230567,-1.132164984,{"v":1.06889E-13,"d":"1.07E-13"},{"v":2.18466e-13,"d":"2.18E-13"},"down","yes","Mms22l","protein_coding","chr5:38197779-38313745:+","gi|209413780|ref|NP_001129252.1|",6358,0,"protein MMS22-like [Rattus norvegicus]","gi|209413779|ref|NM_001135780.1|",4379,0,"Rattus norvegicus MMS22-like, DNA repair protein (Mms22l), mRNA","B1AUR6",2222,0,"Protein MMS22-like",".",".",".",".","pfam14910","MMS22L_N","S-phase genomic integrity recombination mediator, N-terminal. MMS22L (Methyl methanesulfonate-sensitivity protein 22-like) is found in yeast, plants and vertebrates, and is integrally concerned with DNA forking and repair mechanisms during replication. MMS22L complexes with TONSL and this complex accumulates at regions of ssDNA associated with distressed replication forks or at processed DNA breaks. Its depletion results in high levels of endogenous DNA double-strand breaks caused by an inability to complete DNA synthesis after replication fork collapse. Thus the complex mediates recovery from replication stress and homologous recombination in vertebrates, yeasts and plants. This family is the more N-terminal region of the proteins.","GO:0000724|double-strand break repair via homologous recombination;GO:0031297|replication fork processing;","GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0043596|nuclear replication fork;",".",".","."]
["ENSRNOG00000071010",80,6.730821492,251,16.14693998,0.416848115,-1.262406284,{"v":1.3758e-13,"d":"1.38E-13"},{"v":2.791e-13,"d":"2.79E-13"},"down","yes","Bmp2","protein_coding","chr3:120812882-120821397:+","gi|672047173|ref|XP_008760468.1|",2034,0,"PREDICTED: bone morphogenetic protein 2 isoform X1 [Rattus norvegicus]","gi|8392989|ref|NM_017178.1|",1218,0,"Rattus norvegicus bone morphogenetic protein 2 (Bmp2), mRNA","P49001",765,0,"Bone morphogenetic protein 2",".",".",".",".","pfam00688","TGFb_propeptide","TGF-beta propeptide. This propeptide is known as latency associated peptide (LAP) in TGF-beta. LAP is a homodimer which is disulfide linked to TGF-beta binding protein.",".",".",".",".","."]
["ENSRNOG00000003931",82,6.899092029,255,16.40426174,0.420567054,-1.249592258,{"v":1.38167e-13,"d":"1.38E-13"},{"v":2.80186E-13,"d":"2.80E-13"},"down","yes","Arsg","protein_coding","chr10:94447399-94542941:+","gi|114145555|ref|NP_001041342.1|",2823,0,"arylsulfatase G precursor [Rattus norvegicus]","gi|672069769|ref|XM_006247601.2|",3536,0,"PREDICTED: Rattus norvegicus arylsulfatase G (Arsg), transcript variant X5, mRNA","Q32KJ9",1092,0,"Arylsulfatase G","SMa1683",175,{"v":6e-45,"d":"6.00E-45"},"COG3119","pfam00884","Sulfatase","Sulfatase.","GO:0006790|sulfur compound metabolic process;","GO:0005615|extracellular space;GO:0005764|lysosome;GO:0005783|endoplasmic reticulum;","GO:0004065|arylsulfatase activity;GO:0033889|N-sulfoglucosamine-3-sulfatase activity;GO:0046872|metal ion binding;","K12381","ARSG; arylsulfatase G [EC:3.1.6.-]"]
["ENSRNOG00000015799",30,2.524058059,142,9.134922222,0.276308654,-1.855647349,{"v":1.57234e-13,"d":"1.57E-13"},{"v":3.18123e-13,"d":"3.18E-13"},"down","yes","Nat8f1","protein_coding","chr4:118332862-118344035:-","gi|564347547|ref|XP_006236850.1|",1111,{"v":9e-139,"d":"9.00E-139"},"PREDICTED: probable N-acetyltransferase CML1 isoform X1 [Rattus norvegicus]","gi|227498777|ref|NM_021668.3|",2152,0,"Rattus norvegicus N-acetyltransferase 8 (GCN5-related) family member 1 (Nat8f1), mRNA","Q9QXT4",386,{"v":2e-123,"d":"2.00E-123"},"Probable N-acetyltransferase CML1",".",".",".",".","pfam00583","Acetyltransf_1","Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.","GO:0001702|gastrulation with mouth forming second;","GO:0016021|integral component of membrane;","GO:0008080|N-acetyltransferase activity;","K20838","NAT8; N-acetyltransferase 8 [EC:2.3.1.80 2.3.1.-]"]
["ENSRNOG00000062541",70,5.889468805,230,14.79600078,0.39804464,-1.328997859,{"v":1.70082e-13,"d":"1.70E-13"},{"v":3.43753e-13,"d":"3.44E-13"},"down","yes","ENSRNOG00000062541","protein_coding","chr4:29310091-29312643:+","gi|532030848|ref|XP_005358366.1|",2841,0,"PREDICTED: frizzled-1 [Microtus ochrogaster]","gi|158186717|ref|NM_021266.3|",1656,0,"Rattus norvegicus frizzled class receptor 1 (Fzd1), mRNA","Q9UP38",1087,0,"Frizzled-1",".",".",".",".","pfam01534","Frizzled","Frizzled/Smoothened family membrane region. This family contains the membrane spanning region of frizzled and smoothened receptors. This membrane region is predicted to contain seven transmembrane alpha helices. Proteins related to Drosophila frizzled are receptors for Wnt (mediating the beta-catenin signalling pathway), but also the planar cell polarity (PCP) pathway and the Wnt/calcium pathway. The predominantly alpha-helical Cys-rich ligand-binding region (CRD) of Frizzled is both necessary and sufficient for Wnt binding. The smoothened receptor mediates hedgehog signalling.",".",".",".",".","."]
["ENSRNOG00000032729",83,6.983227298,256,16.46859218,0.424033046,-1.237751394,{"v":1.87508e-13,"d":"1.88E-13"},{"v":3.7813e-13,"d":"3.78E-13"},"down","yes","ENSRNOG00000032729","protein_coding","chrX:99019000-99021503:-","gi|116829778|ref|NP_001070903.1|",570,{"v":6e-67,"d":"6.00E-67"},"protein BEX2 [Rattus norvegicus]","gi|22213663|emb|AL671914.9|",838,0,"Mouse DNA sequence from clone RP23-1A3 on chromosome X, complete sequence","Q3MKQ1",224,{"v":2e-68,"d":"2.00E-68"},"Protein BEX2",".",".",".",".","pfam04538","BEX","Brain expressed X-linked like family. This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.","GO:0006915|apoptotic process;GO:0007165|signal transduction;GO:0042981|regulation of apoptotic process;GO:0051726|regulation of cell cycle;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0005102|signaling receptor binding;",".","."]
["ENSRNOG00000015768",17,1.430299567,108,6.947687324,0.205867003,-2.280215486,{"v":2.00293e-13,"d":"2.00E-13"},{"v":4.03017e-13,"d":"4.03E-13"},"down","yes","Nat8f5","protein_coding","chr4:118260252-118285704:-","gi|198278521|ref|NP_543160.1|",1047,{"v":9e-136,"d":"9.00E-136"},"probable N-acetyltransferase CML5 [Rattus norvegicus]","gi|198278520|ref|NM_080884.1|",1191,0,"Rattus norvegicus N-acetyltransferase 8 (GCN5-related) family member 5 (Nat8f5), mRNA","Q9QXS7",375,{"v":1e-124,"d":"1.00E-124"},"Probable N-acetyltransferase CML5",".",".",".",".","pfam00583","Acetyltransf_1","Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.","GO:0001702|gastrulation with mouth forming second;GO:0007368|determination of left/right symmetry;GO:0007507|heart development;","GO:0016021|integral component of membrane;","GO:0008080|N-acetyltransferase activity;","K20838","NAT8; N-acetyltransferase 8 [EC:2.3.1.80 2.3.1.-]"]
["ENSRNOG00000005633",128,10.76931439,342,22.00100986,0.489491821,-1.03064334,{"v":2.1401e-13,"d":"2.14E-13"},{"v":4.29982e-13,"d":"4.30E-13"},"down","yes","Zbtb49","protein_coding","chr14:72590708-72612404:+","gi|564383999|ref|XP_006251154.1|",3962,0,"PREDICTED: zinc finger and BTB domain-containing protein 49 isoform X1 [Rattus norvegicus]","gi|672076404|ref|XM_006251092.2|",2731,0,"PREDICTED: Rattus norvegicus zinc finger and BTB domain containing 49 (Zbtb49), transcript variant X1, mRNA","Q8BXX2",1349,0,"Zinc finger and BTB domain-containing protein 49",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008285|negative regulation of cell proliferation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051726|regulation of cell cycle;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0015630|microtubule cytoskeleton;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001223|transcription coactivator binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0043565|sequence-specific DNA binding;","K24807","ZBTB49; zinc finger and BTB domain-containing protein 49"]
["ENSRNOG00000004699",118,9.9279617,323,20.77873153,0.477794406,-1.065538131,{"v":2.30177e-13,"d":"2.30E-13"},{"v":4.61103e-13,"d":"4.61E-13"},"down","yes","Fibin","protein_coding","chr3:96942406-96944676:-","gi|68163515|ref|NP_001020213.1|",1140,{"v":2e-148,"d":"2.00E-148"},"fin bud initiation factor homolog precursor [Rattus norvegicus]","gi|158262034|ref|NM_001025042.2|",2271,0,"Rattus norvegicus fin bud initiation factor homolog (zebrafish) (Fibin), mRNA","Q5U2T4",443,{"v":7e-150,"d":"7.00E-150"},"Fin bud initiation factor homolog",".",".",".",".","pfam14197","Cep57_CLD_2","Centrosome localisation domain of PPC89. The N-terminal region of the fission yeast spindle pole body protein PPC89 has low similarity to the human Cep57 protein. The CLD or centrosome localisation domain of Cep57 and PPC89 is found at the N-terminus. This region localizes to the centrosome internally to gamma-tubulin, suggesting that it is either on both centrioles or on a centromatrix component. This N-terminal region can also multimerize with the N-terminus of other Cep57 molecules. The C-terminal part, Family Cep57_MT_bd, pfam06657, is the microtubule-binding region of Cep57 and PPC89.","GO:0010042|response to manganese ion;GO:0070528|protein kinase C signaling;GO:0071548|response to dexamethasone;","GO:0005576|extracellular region;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;","GO:0042803|protein homodimerization activity;",".","."]
["ENSRNOG00000019068",103,8.665932671,294,18.91314883,0.458196187,-1.125962643,{"v":2.61662e-13,"d":"2.62E-13"},{"v":5.22446e-13,"d":"5.22E-13"},"down","yes","Ctrb1","protein_coding","chr19:39652933-39657688:-","gi|6978717|ref|NP_036668.1|",1278,{"v":2E-175,"d":"2.00E-175"},"chymotrypsinogen B precursor [Rattus norvegicus]","gi|298893397|emb|FQ234339.1|",795,0,"Rattus norvegicus TL0AEA59YF09 mRNA sequence","P07338",496,{"v":6e-177,"d":"6.00E-177"},"Chymotrypsinogen B","VC1649",105,{"v":2e-24,"d":"2.00E-24"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;GO:0007584|response to nutrient;GO:0007586|digestion;GO:0009636|response to toxic substance;GO:0030163|protein catabolic process;GO:0032094|response to food;GO:0034097|response to cytokine;GO:0043065|positive regulation of apoptotic process;GO:0043434|response to peptide hormone;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005764|lysosome;","GO:0004252|serine-type endopeptidase activity;GO:0005515|protein binding;GO:0008233|peptidase activity;","K01310","CTRB; chymotrypsin [EC:3.4.21.1]"]
["ENSRNOG00000067812",49,4.122628164,184,11.83680063,0.34828906,-1.521642937,{"v":2.87596e-13,"d":"2.88E-13"},{"v":5.72547E-13,"d":"5.73E-13"},"down","yes","ENSRNOG00000067812","protein_coding","chr16:19762596-19855715:+","gi|564388777|ref|XP_006253050.1|",3586,0,"PREDICTED: zinc finger protein 14 isoform X1 [Rattus norvegicus]","gi|672079968|ref|XM_006252988.2|",2539,0,"PREDICTED: Rattus norvegicus zinc finger protein 709-like (LOC102551257), transcript variant X1, mRNA","Q8N972",680,0,"Zinc finger protein 709","SPAC144.09c",109,{"v":6e-24,"d":"6.00E-24"},"COG5048","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000002408",106,8.918338477,299,19.23480102,0.463656394,-1.108872045,{"v":3.2332e-13,"d":"3.23E-13"},{"v":6.4179e-13,"d":"6.42E-13"},"down","yes","Rbm47","protein_coding","chr14:42154142-42189431:+","gi|54312090|ref|NP_001005882.1|",2660,0,"RNA-binding protein 47 [Rattus norvegicus]","gi|672076156|ref|XM_006250949.2|",2367,0,"PREDICTED: Rattus norvegicus RNA binding motif protein 47 (Rbm47), transcript variant X3, mRNA","Q66H68",1029,0,"RNA-binding protein 47",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0002244|hematopoietic progenitor cell differentiation;GO:0016554|cytidine to uridine editing;","GO:0005634|nucleus;","GO:0003723|RNA binding;GO:0003729|mRNA binding;","K25083","RBM47; RNA-binding protein 47"]
["ENSRNOG00000065120",113,9.507285357,312,20.07109671,0.473680412,-1.078014082,{"v":3.52376e-13,"d":"3.52E-13"},{"v":6.97939e-13,"d":"6.98E-13"},"down","yes","ENSRNOG00000065120","protein_coding","chr18:1588008-1590314:+","gi|183396771|ref|NP_034607.3|",2801,0,"60 kDa heat shock protein, mitochondrial [Mus musculus]","gi|206597442|ref|NM_022229.2|",2073,0,"Rattus norvegicus heat shock protein family D member 1 (Hspd1), mRNA","P63039",1083,0,"60 kDa heat shock protein, mitochondrial","SPAC12G12.04",594,0,"COG0459","pfam00118","Cpn60_TCP1","TCP-1/cpn60 chaperonin family. This family includes members from the HSP60 chaperone family and the TCP-1 (T-complex protein) family.",".",".",".",".","."]
["ENSRNOG00000003221",39,3.281275477,161,10.35720055,0.31681104,-1.658305485,{"v":3.656e-13,"d":"3.66E-13"},{"v":7.23078e-13,"d":"7.23E-13"},"down","yes","Myoc","protein_coding","chr13:74976730-74987127:+","gi|149058242|gb|EDM09399.1|",2612,0,"rCG46529 [Rattus norvegicus]","gi|3845606|dbj|AB019393.1|",2024,0,"Rattus norvegicus mRNA for myocilin, complete cds","Q9R1J4",1006,0,"Myocilin",".",".",".",".","pfam02191","OLF","Olfactomedin-like domain.","GO:0001649|osteoblast differentiation;GO:0001953|negative regulation of cell-matrix adhesion;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0014734|skeletal muscle hypertrophy;GO:0021675|nerve development;GO:0022011|myelination in peripheral nervous system;GO:0030335|positive regulation of cell migration;GO:0031175|neuron projection development;GO:0035024|negative regulation of Rho protein signal transduction;GO:0038031|non-canonical Wnt signaling pathway via JNK cascade;GO:0038133|ERBB2-ERBB3 signaling pathway;GO:0043408|regulation of MAPK cascade;GO:0045162|clustering of voltage-gated sodium channels;GO:0051496|positive regulation of stress fiber assembly;GO:0051497|negative regulation of stress fiber assembly;GO:0051894|positive regulation of focal adhesion assembly;GO:0051897|positive regulation of protein kinase B signaling;GO:0051901|positive regulation of mitochondrial depolarization;GO:0060348|bone development;GO:1900026|positive regulation of substrate adhesion-dependent cell spreading;GO:1990090|cellular response to nerve growth factor stimulus;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005741|mitochondrial outer membrane;GO:0005743|mitochondrial inner membrane;GO:0005758|mitochondrial intermembrane space;GO:0005783|endoplasmic reticulum;GO:0005791|rough endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005929|cilium;GO:0031410|cytoplasmic vesicle;GO:0033268|node of Ranvier;GO:0035748|myelin sheath abaxonal region;GO:0043220|Schmidt-Lanterman incisure;GO:0062023|collagen-containing extracellular matrix;GO:0070062|extracellular exosome;GO:0097453|mesaxon;","GO:0001968|fibronectin binding;GO:0003674|molecular_function;GO:0005109|frizzled binding;GO:0030971|receptor tyrosine kinase binding;GO:0032027|myosin light chain binding;GO:0046872|metal ion binding;","K23027","MYOC; myocilin"]
["ENSRNOG00000011892",6,0.504811612,73,4.696121987,0.107495421,-3.217652883,{"v":4.25596e-13,"d":"4.26E-13"},{"v":8.38085e-13,"d":"8.38E-13"},"down","yes","Slc36a2","protein_coding","chr10:39278046-39306082:-","gi|149052650|gb|EDM04467.1|",2381,0,"rCG34384 [Rattus norvegicus]","gi|183985819|gb|BC166414.1|",2285,0,"Rattus norvegicus solute carrier family 36 (proton/amino acid symporter), member 2, mRNA (cDNA clone MGC:187323 IMAGE:9027758), complete cds","Q8K415",894,0,"Proton-coupled amino acid transporter 2","YNL101w",132,{"v":5e-31,"d":"5.00E-31"},"COG0814","pfam01490","Aa_trans","Transmembrane amino acid transporter protein. This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.","GO:0003333|amino acid transmembrane transport;GO:0010155|regulation of proton transport;GO:0015808|L-alanine transport;GO:0015816|glycine transport;GO:0015824|proline transport;GO:0032973|amino acid export across plasma membrane;GO:0035524|proline transmembrane transport;GO:0070881|regulation of proline transport;GO:1900925|positive regulation of glycine import across plasma membrane;GO:1902600|proton transmembrane transport;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0005280|amino acid:proton symporter activity;GO:0015171|amino acid transmembrane transporter activity;GO:0015180|L-alanine transmembrane transporter activity;GO:0015187|glycine transmembrane transporter activity;GO:0015193|L-proline transmembrane transporter activity;","K14209","SLC36A, PAT; solute carrier family 36 (proton-coupled amino acid transporter)"]
["ENSRNOG00000019177",13,1.093758492,95,6.111391628,0.178970447,-2.482206715,{"v":4.33678e-13,"d":"4.34E-13"},{"v":8.53669e-13,"d":"8.54E-13"},"down","yes","Psd2","protein_coding","chr18:27565587-27616672:+","gi|564393056|ref|XP_006254639.1|",3334,0,"PREDICTED: PH and SEC7 domain-containing protein 2 isoform X1 [Rattus norvegicus]","gi|672083033|ref|XM_006254577.2|",4392,0,"PREDICTED: Rattus norvegicus pleckstrin and Sec7 domain containing 2 (Psd2), transcript variant X1, mRNA","Q6P1I6",1170,0,"PH and SEC7 domain-containing protein 2","YDR170c",95.1,{"v":1e-18,"d":"1.00E-18"},"COG5307","pfam01369","Sec7","Sec7 domain. The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.","GO:0032012|regulation of ARF protein signal transduction;GO:0050790|regulation of catalytic activity;","GO:0030425|dendrite;GO:0032154|cleavage furrow;GO:0032587|ruffle membrane;GO:0043025|neuronal cell body;GO:0098794|postsynapse;GO:0098978|glutamatergic synapse;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0005543|phospholipid binding;","K12494","PSD; PH and SEC7 domain-containing protein"]
["ENSRNOG00000007600",52,4.37503397,189,12.15845282,0.359834762,-1.474593531,{"v":4.88244e-13,"d":"4.88E-13"},{"v":9.57297e-13,"d":"9.57E-13"},"down","yes","Igsf1","protein_coding","chrX:129069896-129085139:-","gi|28461163|ref|NP_786939.1|",6634,0,"immunoglobulin superfamily member 1 precursor [Rattus norvegicus]","gi|31343496|ref|NM_175763.2|",4375,0,"Rattus norvegicus immunoglobulin superfamily, member 1 (Igsf1), mRNA","Q925N6",2559,0,"Immunoglobulin superfamily member 1",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0006355|regulation of transcription, DNA-templated;GO:0032926|negative regulation of activin receptor signaling pathway;","GO:0005576|extracellular region;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0015026|coreceptor activity;GO:0034711|inhibin binding;GO:0038102|activin receptor antagonist activity;",".","."]
["ENSRNOG00000056659",57,4.795710313,199,12.8017572,0.374613441,-1.416525432,{"v":6.14289e-13,"d":"6.14E-13"},{"v":1.19839e-12,"d":"1.20E-12"},"down","yes","Mecp2","protein_coding","chrX:151789930-151844689:-","gi|589959860|ref|XP_006992513.1|",1101,{"v":4e-141,"d":"4.00E-141"},"PREDICTED: methyl-CpG-binding protein 2 [Peromyscus maniculatus bairdii]","gi|114225269|gb|DQ897368.1|",1587,0,"Rattus norvegicus methyl CpG binding protein 2 isoform e1 (Mecp2) mRNA, complete cds","Q00566",426,{"v":6e-142,"d":"6.00E-142"},"Methyl-CpG-binding protein 2",".",".",".",".","pfam01429","MBD","Methyl-CpG binding domain. The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001662|behavioral fear response;GO:0001666|response to hypoxia;GO:0001964|startle response;GO:0001976|neurological system process involved in regulation of systemic arterial blood pressure;GO:0002087|regulation of respiratory gaseous exchange by neurological system process;GO:0006020|inositol metabolic process;GO:0006349|regulation of gene expression by genetic imprinting;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006541|glutamine metabolic process;GO:0006576|cellular biogenic amine metabolic process;GO:0006641|triglyceride metabolic process;GO:0007052|mitotic spindle organization;GO:0007268|chemical synaptic transmission;GO:0007416|synapse assembly;GO:0007420|brain development;GO:0007507|heart development;GO:0007585|respiratory gaseous exchange;GO:0007612|learning;GO:0007613|memory;GO:0007616|long-term memory;GO:0008104|protein localization;GO:0008211|glucocorticoid metabolic process;GO:0008284|positive regulation of cell proliferation;GO:0008344|adult locomotory behavior;GO:0008542|visual learning;GO:0009791|post-embryonic development;GO:0010212|response to ionizing radiation;GO:0010288|response to lead ion;GO:0010468|regulation of gene expression;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010971|positive regulation of G2/M transition of mitotic cell cycle;GO:0014003|oligodendrocyte development;GO:0014070|response to organic cyclic compound;GO:0016358|dendrite development;GO:0016525|negative regulation of angiogenesis;GO:0016571|histone methylation;GO:0016573|histone acetylation;GO:0019230|proprioception;GO:0019233|sensory perception of pain;GO:0021510|spinal cord development;GO:0021549|cerebellum development;GO:0021591|ventricular system development;GO:0021740|principal sensory nucleus of trigeminal nerve development;GO:0021756|striatum development;GO:0021766|hippocampus development;GO:0021772|olfactory bulb development;GO:0021794|thalamus development;GO:0021987|cerebral cortex development;GO:0030182|neuron differentiation;GO:0031175|neuron projection development;GO:0031915|positive regulation of synaptic plasticity;GO:0032048|cardiolipin metabolic process;GO:0032091|negative regulation of protein binding;GO:0032355|response to estradiol;GO:0033555|multicellular organismal response to stress;GO:0035176|social behavior;GO:0035865|cellular response to potassium ion;GO:0040029|regulation of gene expression, epigenetic;GO:0042220|response to cocaine;GO:0042551|neuron maturation;GO:0043524|negative regulation of neuron apoptotic process;GO:0043537|negative regulation of blood vessel endothelial cell migration;GO:0044030|regulation of DNA methylation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046470|phosphatidylcholine metabolic process;GO:0048167|regulation of synaptic plasticity;GO:0048286|lung alveolus development;GO:0048709|oligodendrocyte differentiation;GO:0048712|negative regulation of astrocyte differentiation;GO:0050807|regulation of synapse organization;GO:0050884|neuromuscular process controlling posture;GO:0050905|neuromuscular process;GO:0051151|negative regulation of smooth muscle cell differentiation;GO:0051570|regulation of histone H3-K9 methylation;GO:0051707|response to other organism;GO:0060079|excitatory postsynaptic potential;GO:0060291|long-term synaptic potentiation;GO:0060999|positive regulation of dendritic spine development;GO:0061000|negative regulation of dendritic spine development;GO:0071317|cellular response to isoquinoline alkaloid;GO:0090063|positive regulation of microtubule nucleation;GO:0090327|negative regulation of locomotion involved in locomotory behavior;GO:0099611|regulation of action potential firing threshold;GO:1900114|positive regulation of histone H3-K9 trimethylation;GO:1901953|positive regulation of anterograde dense core granule transport;GO:1901956|positive regulation of retrograde dense core granule transport;GO:1903860|negative regulation of dendrite extension;GO:1903861|positive regulation of dendrite extension;GO:1903941|negative regulation of respiratory gaseous exchange;GO:1905492|positive regulation of branching morphogenesis of a nerve;GO:1905643|positive regulation of DNA methylation;GO:2000635|negative regulation of primary miRNA processing;GO:2000820|negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation;","GO:0000785|chromatin;GO:0000792|heterochromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0005829|cytosol;GO:0032991|protein-containing complex;GO:0098794|postsynapse;GO:0098978|glutamatergic synapse;","GO:0000400|four-way junction DNA binding;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003700|DNA-binding transcription factor activity;GO:0003714|transcription corepressor activity;GO:0003729|mRNA binding;GO:0005515|protein binding;GO:0008327|methyl-CpG binding;GO:0010385|double-stranded methylated DNA binding;GO:0019899|enzyme binding;GO:0019904|protein domain specific binding;GO:0031490|chromatin DNA binding;GO:0035197|siRNA binding;GO:0042826|histone deacetylase binding;GO:0045322|unmethylated CpG binding;GO:0047485|protein N-terminus binding;GO:1990841|promoter-specific chromatin binding;","K11588","MECP2; methyl CpG binding protein 2"]
["ENSRNOG00000031739",46,3.870222358,175,11.25782668,0.343780595,-1.540439981,{"v":6.77931e-13,"d":"6.78E-13"},{"v":1.32113E-12,"d":"1.32E-12"},"down","yes","Fam71e1","protein_coding","chr1:94988613-94993539:+","gi|672013525|ref|XP_008772744.1|",929,{"v":9e-121,"d":"9.00E-121"},"PREDICTED: protein FAM71E1 isoform X3 [Rattus norvegicus]","gi|672013524|ref|XM_008774522.1|",1389,0,"PREDICTED: Rattus norvegicus family with sequence similarity 71, member E1 (Fam71e1), transcript variant X3, mRNA","A1L3C1",290,{"v":3e-94,"d":"3.00E-94"},"Protein FAM71E1",".",".",".",".","pfam12480","DUF3699","Protein of unknown function (DUF3699). This domain family is found in eukaryotes, and is approximately 80 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000007189",32,2.692328597,143,9.19925266,0.292668187,-1.772662162,{"v":7.06959e-13,"d":"7.07E-13"},{"v":1.3772E-12,"d":"1.38E-12"},"down","yes","Ttc22","protein_coding","chr5:121406326-121423130:+","gi|157821039|ref|NP_001100141.1|",2853,0,"tetratricopeptide repeat protein 22 [Rattus norvegicus]","gi|157821038|ref|NM_001106671.1|",2553,0,"Rattus norvegicus tetratricopeptide repeat domain 22 (Ttc22), mRNA",".",".",".",".",".",".",".",".","pfam13414","TPR_11","TPR repeat.",".",".",".","K24933","TTC22; tetratricopeptide repeat protein 22"]
["ENSRNOG00000062479",17,1.430299567,105,6.754696009,0.211748917,-2.239573502,{"v":7.66772e-13,"d":"7.67E-13"},{"v":1.48893E-12,"d":"1.49E-12"},"down","yes","ENSRNOG00000062479","protein_coding","chr2:215692196-215697408:+","gi|293347239|ref|XP_002726534.1|",651,{"v":2e-69,"d":"2.00E-69"},"PREDICTED: uncharacterized protein LOC100364265 [Rattus norvegicus]","gi|33457292|gb|AC131744.3|",1640,0,"Mus musculus BAC clone RP23-50E10 from chromosome 3, complete sequence","P11260",155,{"v":3e-39,"d":"3.00E-39"},"LINE-1 retrotransposable element ORF1 protein",".",".",".",".","pfam02994","Transposase_22","L1 transposable element.",".",".",".",".","."]
["ENSRNOG00000055221",59,4.96398085,202,12.99474851,0.381998993,-1.388359259,{"v":9.20432e-13,"d":"9.20E-13"},{"v":1.7778E-12,"d":"1.78E-12"},"down","yes","Acot1","protein_coding","chr6:103636041-103644163:+","gi|149025102|gb|EDL81469.1|",2017,0,"rCG20735, isoform CRA_a [Rattus norvegicus]","gi|3445485|dbj|AB010428.1|",1533,0,"Rattus norvegicus mRNA for acyl-CoA hydrolase, complete cds","O88267",780,0,"Acyl-coenzyme A thioesterase 1","CAC3407",144,{"v":8e-37,"d":"8.00E-37"},"COG1073","pfam08840","BAAT_C","BAAT / Acyl-CoA thioester hydrolase C terminal. This catalytic domain is found at the C terminal of acyl-CoA thioester hydrolases and bile acid-CoA:amino acid N-acetyltransferases (BAAT).","GO:0000038|very long-chain fatty acid metabolic process;GO:0001676|long-chain fatty acid metabolic process;GO:0006631|fatty acid metabolic process;GO:0006637|acyl-CoA metabolic process;GO:0010667|negative regulation of cardiac muscle cell apoptotic process;","GO:0005829|cytosol;","GO:0016290|palmitoyl-CoA hydrolase activity;GO:0016790|thiolester hydrolase activity;GO:0047617|acyl-CoA hydrolase activity;GO:0052689|carboxylic ester hydrolase activity;GO:0102991|myristoyl-CoA hydrolase activity;","K01068","ACOT1_2_4; acyl-coenzyme A thioesterase 1/2/4 [EC:3.1.2.2]"]
["ENSRNOG00000050206",38,3.197140209,156,10.03554836,0.318581516,-1.650265531,{"v":1.0094e-12,"d":"1.01E-12"},{"v":1.94411e-12,"d":"1.94E-12"},"down","yes","Shank2","protein_coding","chr1:199169429-199589394:+","gi|40255311|ref|NP_597685.1|",6211,0,"SH3 and multiple ankyrin repeat domains protein 2 isoform d [Rattus norvegicus]","gi|40255310|ref|NM_133441.1|",8049,0,"Rattus norvegicus SH3 and multiple ankyrin repeat domains 2 (Shank2), transcript variant 4, mRNA","Q9QX74",2392,0,"SH3 and multiple ankyrin repeat domains protein 2",".",".",".",".","pfam00536","SAM_1","SAM domain (Sterile alpha motif). It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.","GO:0007416|synapse assembly;GO:0007420|brain development;GO:0007584|response to nutrient;GO:0007612|learning;GO:0007613|memory;GO:0008284|positive regulation of cell proliferation;GO:0008306|associative learning;GO:0008344|adult locomotory behavior;GO:0009410|response to xenobiotic stimulus;GO:0030534|adult behavior;GO:0035176|social behavior;GO:0035331|negative regulation of hippo signaling;GO:0035640|exploration behavior;GO:0050807|regulation of synapse organization;GO:0051968|positive regulation of synaptic transmission, glutamatergic;GO:0060291|long-term synaptic potentiation;GO:0060292|long-term synaptic depression;GO:0071625|vocalization behavior;GO:0099562|maintenance of postsynaptic density structure;","GO:0001750|photoreceptor outer segment;GO:0001917|photoreceptor inner segment;GO:0005737|cytoplasm;GO:0005883|neurofilament;GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0016324|apical plasma membrane;GO:0030426|growth cone;GO:0031526|brush border membrane;GO:0032279|asymmetric synapse;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043197|dendritic spine;GO:0045211|postsynaptic membrane;GO:0048786|presynaptic active zone;GO:0060170|ciliary membrane;GO:0098686|hippocampal mossy fiber to CA3 synapse;GO:0098978|glutamatergic synapse;","GO:0005515|protein binding;GO:0008022|protein C-terminus binding;GO:0017124|SH3 domain binding;GO:0030160|GKAP/Homer scaffold activity;GO:0035255|ionotropic glutamate receptor binding;GO:0098919|structural constituent of postsynaptic density;","K15009","SHANK; SH3 and multiple ankyrin repeat domains protein"]
["ENSRNOG00000065794",35,2.944734403,149,9.58523529,0.307215662,-1.702676329,{"v":1.05054e-12,"d":"1.05E-12"},{"v":2.01978e-12,"d":"2.02E-12"},"down","yes","Mafk","lncRNA","chr12:14832249-14858888:-","gi|149035030|gb|EDL89750.1|",720,{"v":1E-83,"d":"1.00E-83"},"v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) [Rattus norvegicus]","gi|47575873|ref|NM_145673.2|",2646,0,"Rattus norvegicus v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K (Mafk), mRNA","Q61827",268,{"v":1e-80,"d":"1.00E-80"},"Transcription factor MafK",".",".",".",".","pfam03131","bZIP_Maf","bZIP Maf transcription factor. Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerization and DNA binding property. Thus, this family is probably related to pfam00170. This family also includes the DNA_binding domain of Skn-1, this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer.",".",".",".",".","."]
["ENSRNOG00000016653",90,7.572174178,264,16.98323568,0.445861691,-1.165331848,{"v":1.05469E-12,"d":"1.05E-12"},{"v":2.02634E-12,"d":"2.03E-12"},"down","yes","Ngef","protein_coding","chr9:88146956-88244914:-","gi|114152091|sp|Q5BKC9.2|NGEF_RAT",3676,0,"RecName: Full=Ephexin-1; AltName: Full=Eph-interacting exchange protein; AltName: Full=Neuronal guanine nucleotide exchange factor","gi|210031333|ref|NM_001136241.1|",2476,0,"Rattus norvegicus neuronal guanine nucleotide exchange factor (Ngef), mRNA","Q5BKC9",1420,0,"Ephexin-1",".",".",".",".","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0007399|nervous system development;GO:0009987|cellular process;GO:0030154|cell differentiation;GO:0043087|regulation of GTPase activity;GO:0048013|ephrin receptor signaling pathway;GO:0050790|regulation of catalytic activity;GO:0061002|negative regulation of dendritic spine morphogenesis;GO:0090630|activation of GTPase activity;GO:0098883|synapse pruning;","GO:0005737|cytoplasm;GO:0016020|membrane;GO:0030426|growth cone;GO:0098978|glutamatergic synapse;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0046875|ephrin receptor binding;","K07525","NGEF, EPHEXIN, ARHGEF27; neuronal guanine nucleotide exchange factor"]
["ENSRNOG00000018040",72,6.057739343,228,14.66733991,0.413008724,-1.275755838,{"v":1.16364e-12,"d":"1.16E-12"},{"v":2.23092e-12,"d":"2.23E-12"},"down","yes","Gins4","protein_coding","chr16:68767339-68802273:+","gi|149057787|gb|EDM09030.1|",1166,{"v":2e-154,"d":"2.00E-154"},"similar to RIKEN cDNA 2810037C03 [Rattus norvegicus]","gi|71795642|ref|NM_001030027.1|",1041,0,"Rattus norvegicus GINS complex subunit 4 (Sld5 homolog) (Gins4), mRNA","Q499W2",450,{"v":2e-154,"d":"2.00E-154"},"DNA replication complex GINS protein SLD5","SPBP4H10.21c",78.6,{"v":2e-15,"d":"2.00E-15"},"COG5086","pfam10256","Erf4","Golgin subfamily A member 7/ERF4 family. This family of proteins includes Golgin subfamily A member 7 proteins as well as Ras modification protein ERF4.","GO:0000727|double-strand break repair via break-induced replication;GO:0001833|inner cell mass cell proliferation;GO:0006261|DNA-dependent DNA replication;","GO:0000811|GINS complex;GO:0005634|nucleus;GO:0005694|chromosome;GO:0005737|cytoplasm;GO:0071162|CMG complex;",".","K10735","GINS4, SLD5; GINS complex subunit 4"]
["ENSRNOG00000001704",49,4.122628164,180,11.57947887,0.356028817,-1.489934077,{"v":1.17066E-12,"d":"1.17E-12"},{"v":2.2436e-12,"d":"2.24E-12"},"down","yes","Runx1","protein_coding","chr11:31843764-32074542:-","gi|8392900|ref|NP_059021.1|",2098,0,"runt-related transcription factor 1 [Rattus norvegicus]","gi|830260147|ref|NM_017325.2|",2135,0,"Rattus norvegicus runt-related transcription factor 1 (Runx1), mRNA","Q63046",812,0,"Runt-related transcription factor 1",".",".",".",".","pfam00853","Runt","Runt domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001501|skeletal system development;GO:0001503|ossification;GO:0001701|in utero embryonic development;GO:0001889|liver development;GO:0002062|chondrocyte differentiation;GO:0002318|myeloid progenitor cell differentiation;GO:0002573|myeloid leukocyte differentiation;GO:0002667|regulation of T cell anergy;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007417|central nervous system development;GO:0008285|negative regulation of cell proliferation;GO:0009966|regulation of signal transduction;GO:0014894|response to denervation involved in regulation of muscle adaptation;GO:0030097|hemopoiesis;GO:0030099|myeloid cell differentiation;GO:0030182|neuron differentiation;GO:0030728|ovulation;GO:0030853|negative regulation of granulocyte differentiation;GO:0030854|positive regulation of granulocyte differentiation;GO:0031069|hair follicle morphogenesis;GO:0032526|response to retinoic acid;GO:0032729|positive regulation of interferon-gamma production;GO:0032743|positive regulation of interleukin-2 production;GO:0035162|embryonic hemopoiesis;GO:0043371|negative regulation of CD4-positive, alpha-beta T cell differentiation;GO:0043378|positive regulation of CD8-positive, alpha-beta T cell differentiation;GO:0045595|regulation of cell differentiation;GO:0045766|positive regulation of angiogenesis;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048266|behavioral response to pain;GO:0048663|neuron fate commitment;GO:0048666|neuron development;GO:0060216|definitive hemopoiesis;GO:0071336|regulation of hair follicle cell proliferation;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:1903431|positive regulation of cell maturation;GO:2000872|positive regulation of progesterone secretion;","GO:0000785|chromatin;GO:0005604|basement membrane;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0016513|core-binding factor complex;GO:0043231|intracellular membrane-bounded organelle;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0005509|calcium ion binding;GO:0005524|ATP binding;GO:0042803|protein homodimerization activity;GO:0046982|protein heterodimerization activity;GO:1990837|sequence-specific double-stranded DNA binding;GO:1990841|promoter-specific chromatin binding;","K08367","RUNX1, AML1; runt-related transcription factor 1"]
["ENSRNOG00000055142",34,2.860599134,146,9.392243975,0.304570361,-1.715152543,{"v":1.36096e-12,"d":"1.36E-12"},{"v":2.59825e-12,"d":"2.60E-12"},"down","yes","Ect2l","protein_coding","chr1:12778922-12855449:-","gi|564295993|ref|XP_006222887.1|",4356,0,"PREDICTED: epithelial cell-transforming sequence 2 oncogene-like isoform X3 [Rattus norvegicus]","gi|672012470|ref|XM_006222829.2|",1411,0,"PREDICTED: Rattus norvegicus epithelial cell transforming 2 like (Ect2l), transcript variant X7, mRNA","Q008S8",1190,0,"Epithelial cell-transforming sequence 2 oncogene-like",".",".",".",".","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0050790|regulation of catalytic activity;",".","GO:0005085|guanyl-nucleotide exchange factor activity;",".","."]
["ENSRNOG00000025126",63,5.300521925,209,13.44506158,0.3942356,-1.342870034,{"v":1.41897E-12,"d":"1.42E-12"},{"v":2.70615e-12,"d":"2.71E-12"},"down","yes","Palb2","protein_coding","chr1:176665076-176688990:-","gi|300797913|ref|NP_001178532.1|",5499,0,"partner and localizer of BRCA2 [Rattus norvegicus]","gi|300797912|ref|NM_001191603.1|",3525,0,"Rattus norvegicus partner and localizer of BRCA2 (Palb2), mRNA","Q3U0P1",1719,0,"Partner and localizer of BRCA2",".",".",".",".","pfam05109","Herpes_BLLF1","Herpes virus major outer envelope glycoprotein (BLLF1). This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralizing antibodies in vivo.","GO:0000724|double-strand break repair via homologous recombination;GO:0001701|in utero embryonic development;GO:0001756|somitogenesis;GO:0001833|inner cell mass cell proliferation;GO:0007498|mesoderm development;GO:0008150|biological_process;GO:0009887|animal organ morphogenesis;GO:0035264|multicellular organism growth;GO:0036342|post-anal tail morphogenesis;GO:0043066|negative regulation of apoptotic process;GO:0048568|embryonic organ development;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0032991|protein-containing complex;","GO:0003674|molecular_function;GO:0003677|DNA binding;","K10897","PALB2, FANCN; partner and localizer of BRCA2"]
["ENSRNOG00000069705",54,4.543304507,190,12.22278326,0.371707852,-1.427758931,{"v":1.49857e-12,"d":"1.50E-12"},{"v":2.85396e-12,"d":"2.85E-12"},"down","yes","ENSRNOG00000069705","lncRNA","chr16:46842387-46854011:-","gi|73532753|ref|NP_001020228.2|",177,{"v":2e-11,"d":"2.00E-11"},"uncharacterized protein LOC502176 [Rattus norvegicus]","gi|959093084|ref|NG_046269.1|",482,0,"Rattus norvegicus Y-linked testis-specific protein 1-like (LOC103694772) pseudogene on chromosome Y",".",".",".",".",".",".",".",".","pfam10110","GPDPase_memb","Membrane domain of glycerophosphoryl diester phosphodiesterase. Members of this family comprise the membrane domain of the prokaryotic enzyme glycerophosphoryl diester phosphodiesterase.",".",".",".",".","."]
["ENSRNOG00000051507",55,4.627439776,192,12.35144413,0.374647671,-1.416393612,{"v":1.5599E-12,"d":"1.56E-12"},{"v":2.96248e-12,"d":"2.96E-12"},"down","yes","Azin2","protein_coding","chr5:141281249-141310397:-","gi|651167457|ref|NP_001014283.2|",2437,0,"antizyme inhibitor 2 [Rattus norvegicus]","gi|686223154|ref|NM_001014261.3|",1715,0,"Rattus norvegicus antizyme inhibitor 2 (Azin2), mRNA","Q8BVM4",917,0,"Antizyme inhibitor 2","SPAC144.04c",298,{"v":2E-91,"d":"2.00E-91"},"COG0019","pfam02784","Orn_Arg_deC_N","Pyridoxal-dependent decarboxylase, pyridoxal binding domain. These pyridoxal-dependent decarboxylases acting on ornithine, lysine, arginine and related substrates This domain has a TIM barrel fold.","GO:0006591|ornithine metabolic process;GO:0006596|polyamine biosynthetic process;GO:0033387|putrescine biosynthetic process from ornithine;GO:0042177|negative regulation of protein catabolic process;GO:0043085|positive regulation of catalytic activity;GO:0050790|regulation of catalytic activity;GO:0098629|trans-Golgi network membrane organization;GO:1902269|positive regulation of polyamine transmembrane transport;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005801|cis-Golgi network;GO:0005802|trans-Golgi network;GO:0005829|cytosol;GO:0030133|transport vesicle;GO:0030424|axon;GO:0030425|dendrite;GO:0031410|cytoplasmic vesicle;GO:0033116|endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0043204|perikaryon;GO:0048471|perinuclear region of cytoplasm;GO:1990005|granular vesicle;","GO:0003824|catalytic activity;GO:0042978|ornithine decarboxylase activator activity;","K01583","E4.1.1.19; arginine decarboxylase [EC:4.1.1.19]"]
["ENSRNOG00000042975",80,6.730821492,243,15.63229648,0.430571509,-1.215675234,{"v":1.57973E-12,"d":"1.58E-12"},{"v":2.99804E-12,"d":"3.00E-12"},"down","yes","Tmem45al","protein_coding","chr11:43713782-43799526:+","gi|300797305|ref|NP_001178003.1|",1334,{"v":5e-180,"d":"5.00E-180"},"transmembrane protein 45A [Rattus norvegicus]","gi|672070962|ref|XM_003751037.3|",1581,0,"PREDICTED: Rattus norvegicus transmembrane protein 45A-like (Tmem45al), transcript variant X3, mRNA","Q60774",446,{"v":3E-153,"d":"3.00E-153"},"Transmembrane protein 45A",".",".",".",".","pfam04819","DUF716","Family of unknown function (DUF716). This family is equally distributed in both metazoa and plants. Annotation associated with a member from Nicotiana tabacum suggest that it may be involved in response to viral attack in plants. However, no clear function has been assigned to this family.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000004555",39,3.281275477,157,10.0998788,0.324882659,-1.622009355,{"v":1.61684E-12,"d":"1.62E-12"},{"v":3.06421e-12,"d":"3.06E-12"},"down","yes","Sec14l4","protein_coding","chr14:78912750-78956099:+","gi|29427387|sp|Q9Z1J8.1|S14L3_RAT",1935,0,"RecName: Full=SEC14-like protein 3; AltName: Full=45 kDa secretory protein; Short=rsec45","gi|4164417|emb|AJ132352.1|",1119,0,"Rattus norvegicus mRNA for 45 kDa secretory protein, partial","Q9Z1J8",749,0,"SEC14-like protein 3",".",".",".",".","pfam00650","CRAL_TRIO","CRAL/TRIO domain.",".",".","GO:0008289|lipid binding;",".","."]
["ENSRNOG00000027837",30,2.524058059,136,8.748939593,0.288498741,-1.793363071,{"v":1.70652e-12,"d":"1.71E-12"},{"v":3.23079e-12,"d":"3.23E-12"},"down","yes","ENSRNOG00000027837","protein_coding","chrX:115675427-115725925:-","gi|149059998|gb|EDM10814.1|",2618,0,"similar to novel protein (predicted), partial [Rattus norvegicus]","gi|755490487|ref|XM_006544556.2|",1435,0,"PREDICTED: Mus musculus predicted gene 14569 (Gm14569), transcript variant X3, mRNA","E9Q0C6",484,{"v":3e-140,"d":"3.00E-140"},"Acrosomal protein KIAA1210",".",".",".",".","pfam15262","DUF4592","Domain of unknown function (DUF4592). This protein family is a domain of unknown function, which lies to the N-terminus of the protein. This domain family is found in eukaryotes, and is typically between 114 and 130 amino acids in length. There are two completely conserved residues (L and A) that may be functionally important. In humans, the gene that encodes this protein lies in the position, chromosome 2 open reading frame 55.",".","GO:0001669|acrosomal vesicle;GO:0061832|basal ectoplasmic specialization;",".",".","."]
["ENSRNOG00000013123",91,7.656309447,264,16.98323568,0.45081571,-1.149390304,{"v":1.85241e-12,"d":"1.85E-12"},{"v":3.49361e-12,"d":"3.49E-12"},"down","yes","Scube2","protein_coding","chr1:163832015-163899393:-","gi|392337862|ref|XP_003753378.1|",5085,0,"PREDICTED: signal peptide, CUB and EGF-like domain-containing protein 2 isoform X1 [Rattus norvegicus]","gi|672014129|ref|XM_003753330.3|",3506,0,"PREDICTED: Rattus norvegicus signal peptide, CUB domain, EGF-like 2 (Scube2), transcript variant X1, mRNA","Q9JJS0",1737,0,"Signal peptide, CUB and EGF-like domain-containing protein 2",".",".",".",".","pfam00431","CUB","CUB domain.","GO:0003413|chondrocyte differentiation involved in endochondral bone morphogenesis;GO:0007165|signal transduction;GO:0045669|positive regulation of osteoblast differentiation;GO:0045778|positive regulation of ossification;GO:0045880|positive regulation of smoothened signaling pathway;GO:1902732|positive regulation of chondrocyte proliferation;","GO:0005615|extracellular space;GO:0009986|cell surface;","GO:0005509|calcium ion binding;GO:0097108|hedgehog family protein binding;","K24706","SCUBE2; signal peptide, CUB and EGF-like domain-containing protein 2"]
["ENSRNOG00000018854",37,3.11300494,152,9.778226604,0.318360892,-1.651264973,{"v":1.91871E-12,"d":"1.92E-12"},{"v":3.61365e-12,"d":"3.61E-12"},"down","yes","Nppc","protein_coding","chr9:87320051-87324251:-","gi|676275715|gb|KFO30090.1|",397,{"v":2e-43,"d":"2.00E-43"},"C-type natriuretic peptide [Fukomys damarensis]","gi|16758581|ref|NM_053750.1|",1020,0,"Rattus norvegicus natriuretic peptide C (Nppc), mRNA","P55207",151,{"v":3E-43,"d":"3.00E-43"},"C-type natriuretic peptide",".",".",".",".","pfam00212","ANP","Atrial natriuretic peptide.","GO:0001503|ossification;GO:0001666|response to hypoxia;GO:0003418|growth plate cartilage chondrocyte differentiation;GO:0003419|growth plate cartilage chondrocyte proliferation;GO:0006182|cGMP biosynthetic process;GO:0006457|protein folding;GO:0007168|receptor guanylyl cyclase signaling pathway;GO:0008285|negative regulation of cell proliferation;GO:0009410|response to xenobiotic stimulus;GO:0009791|post-embryonic development;GO:0010753|positive regulation of cGMP-mediated signaling;GO:0019934|cGMP-mediated signaling;GO:0022414|reproductive process;GO:0032966|negative regulation of collagen biosynthetic process;GO:0040014|regulation of multicellular organism growth;GO:0043306|positive regulation of mast cell degranulation;GO:0045471|response to ethanol;GO:0045669|positive regulation of osteoblast differentiation;GO:0048513|animal organ development;GO:0048660|regulation of smooth muscle cell proliferation;GO:0051447|negative regulation of meiotic cell cycle;GO:1900194|negative regulation of oocyte maturation;GO:1900721|positive regulation of uterine smooth muscle relaxation;GO:2000279|negative regulation of DNA biosynthetic process;","GO:0005615|extracellular space;GO:0030141|secretory granule;GO:0032991|protein-containing complex;","GO:0005102|signaling receptor binding;GO:0005179|hormone activity;GO:0051427|hormone receptor binding;","K12336","NPPC; natriuretic peptide C"]
["ENSRNOG00000019435",86,7.235633104,254,16.3399313,0.442819065,-1.175210757,{"v":2.00493E-12,"d":"2.00E-12"},{"v":3.76302e-12,"d":"3.76E-12"},"down","yes","Psd","protein_coding","chr1:245173279-245189356:-","gi|209870095|ref|NP_599197.2|",4479,0,"PH and SEC7 domain-containing protein 1 [Rattus norvegicus]","gi|209870094|ref|NM_134370.2|",3799,0,"Rattus norvegicus pleckstrin and Sec7 domain containing (Psd), mRNA","Q5DTT2",1681,0,"PH and SEC7 domain-containing protein 1","YDR170c",108,{"v":7e-23,"d":"7.00E-23"},"COG5307","pfam01369","Sec7","Sec7 domain. The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.","GO:0015854|guanine transport;GO:0030182|neuron differentiation;GO:0031175|neuron projection development;GO:0032012|regulation of ARF protein signal transduction;GO:0050790|regulation of catalytic activity;GO:1903790|guanine nucleotide transmembrane transport;","GO:0014069|postsynaptic density;GO:0016021|integral component of membrane;GO:0032154|cleavage furrow;GO:0032587|ruffle membrane;GO:0043197|dendritic spine;GO:0098999|extrinsic component of postsynaptic endosome membrane;GO:0099092|postsynaptic density, intracellular component;","GO:0001409|guanine nucleotide transmembrane transporter activity;GO:0005085|guanyl-nucleotide exchange factor activity;GO:0005543|phospholipid binding;","K12494","PSD; PH and SEC7 domain-containing protein"]
["ENSRNOG00000002167",15,1.26202903,97,6.240052504,0.20224654,-2.305813072,{"v":2.36065E-12,"d":"2.36E-12"},{"v":4.41697e-12,"d":"4.42E-12"},"down","yes","Dmp1","protein_coding","chr14:5528431-5539323:-","gi|672075644|ref|XP_008768216.1|",1015,{"v":9e-123,"d":"9.00E-123"},"PREDICTED: dentin matrix acidic phosphoprotein 1 isoform X1 [Rattus norvegicus]","gi|672075645|ref|XM_006250622.2|",2774,0,"PREDICTED: Rattus norvegicus dentin matrix acidic phosphoprotein 1 (Dmp1), transcript variant X2, mRNA","P98193",359,{"v":1e-111,"d":"1.00E-111"},"Dentin matrix acidic phosphoprotein 1",".",".",".",".","pfam07263","DMP1","Dentin matrix protein 1 (DMP1). This family consists of several mammalian dentin matrix protein 1 (DMP1) sequences. The dentin matrix acidic phosphoprotein 1 (DMP1) gene has been mapped to human chromosome 4q21. DMP1 is a bone and teeth specific protein initially identified from mineralised dentin. DMP1 is primarily localized in the nuclear compartment of undifferentiated osteoblasts. In the nucleus, DMP1 acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the early phase of osteoblast maturation, Ca(2+) surges into the nucleus from the cytoplasm, triggering the phosphorylation of DMP1 by a nuclear isoform of casein kinase II. This phosphorylated DMP1 is then exported out into the extracellular matrix, where it regulates nucleation of hydroxyapatite. DMP1 is a unique molecule that initiates osteoblast differentiation by transcription in the nucleus and orchestrates mineralised matrix formation extracellularly, at later stages of osteoblast maturation. The DMP1 gene has been found to be ectopically expressed in lung cancer although the reason for this is unknown.","GO:0001503|ossification;GO:0010811|positive regulation of cell-substrate adhesion;GO:0030198|extracellular matrix organization;GO:0030500|regulation of bone mineralization;GO:0031214|biomineral tissue development;GO:0070173|regulation of enamel mineralization;","GO:0005576|extracellular region;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0031012|extracellular matrix;","GO:0030544|Hsp70 protein binding;GO:0050840|extracellular matrix binding;","K23328","DMP1; dentin matrix acidic phosphoprotein 1"]
["ENSRNOG00000021704",112,9.423150088,303,19.49212277,0.483433754,-1.048609887,{"v":2.43207e-12,"d":"2.43E-12"},{"v":4.54279e-12,"d":"4.54E-12"},"down","yes","Atp8b5p","protein_coding","chr5:57506466-57620056:+","gi|672019256|ref|XP_008774160.1|",5941,0,"PREDICTED: phospholipid-transporting ATPase FetA isoform X2 [Rattus norvegicus]","gi|672019255|ref|XM_008775938.1|",4291,0,"PREDICTED: Rattus norvegicus ATPase, class I, type 8B, member 5, pseudogene (Atp8b5p), transcript variant X2, mRNA","A3FIN4",2161,0,"Phospholipid-transporting ATPase FetA","YAL026c",718,0,"COG0474","pfam13246","Hydrolase_like2","Putative hydrolase of sodium-potassium ATPase alpha subunit. This is a putative hydrolase of the sodium-potassium ATPase alpha subunit.","GO:0007030|Golgi organization;GO:0045332|phospholipid translocation;","GO:0001669|acrosomal vesicle;GO:0005802|trans-Golgi network;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0000287|magnesium ion binding;GO:0005524|ATP binding;GO:0090555|phosphatidylethanolamine-translocating ATPase activity;","K01530","E7.6.2.1; phospholipid-translocating ATPase [EC:7.6.2.1]"]
["ENSRNOG00000011452",51,4.290898701,182,11.70813975,0.366488511,-1.448160124,{"v":2.59211e-12,"d":"2.59E-12"},{"v":4.83343e-12,"d":"4.83E-12"},"down","yes","Aldoc","protein_coding","chr10:63217451-63221066:+","gi|537141321|gb|ERE67891.1|",1966,0,"sperm-associated antigen 5 [Cricetulus griseus]","gi|298913395|emb|FQ214420.1|",1593,0,"Rattus norvegicus TL0AAA41YM18 mRNA sequence","P09117",750,0,"Fructose-bisphosphate aldolase C","mlr3754",339,{"v":7e-111,"d":"7.00E-111"},"COG3588","pfam00274","Glycolytic","Fructose-bisphosphate aldolase class-I.","GO:0001666|response to hypoxia;GO:0006096|glycolytic process;GO:0006915|apoptotic process;GO:0007568|aging;GO:0010243|response to organonitrogen compound;GO:0014070|response to organic cyclic compound;GO:0030388|fructose 1,6-bisphosphate metabolic process;GO:0030855|epithelial cell differentiation;GO:0031100|animal organ regeneration;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0030424|axon;GO:0099524|postsynaptic cytosol;","GO:0004332|fructose-bisphosphate aldolase activity;GO:0005515|protein binding;GO:0008092|cytoskeletal protein binding;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;","K01623","ALDO; fructose-bisphosphate aldolase, class I [EC:4.1.2.13]"]
["ENSRNOG00000002338",68,5.721198268,217,13.95970509,0.409836614,-1.286879216,{"v":2.88951e-12,"d":"2.89E-12"},{"v":5.37878e-12,"d":"5.38E-12"},"down","yes","Dgke","protein_coding","chr10:73855583-73877100:-","gi|564373655|ref|XP_006247132.1|",2984,0,"PREDICTED: diacylglycerol kinase epsilon isoform X1 [Rattus norvegicus]","gi|672068870|ref|XM_006247070.2|",3007,0,"PREDICTED: Rattus norvegicus diacylglycerol kinase, epsilon 64kDa (Dgke), transcript variant X1, mRNA","Q9R1C6",1083,0,"Diacylglycerol kinase epsilon",".",".",".",".","pfam00609","DAGK_acc","Diacylglycerol kinase accessory domain. Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. This domain is assumed to be an accessory domain: its function is unknown.","GO:0006654|phosphatidic acid biosynthetic process;GO:0006661|phosphatidylinositol biosynthetic process;GO:0007205|protein kinase C-activating G protein-coupled receptor signaling pathway;GO:0035556|intracellular signal transduction;GO:0046339|diacylglycerol metabolic process;GO:0046834|lipid phosphorylation;GO:0050804|modulation of chemical synaptic transmission;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0098978|glutamatergic synapse;","GO:0003951|NAD+ kinase activity;GO:0004143|diacylglycerol kinase activity;GO:0005524|ATP binding;GO:0016301|kinase activity;","K00901","dgkA, DGK; diacylglycerol kinase (ATP) [EC:2.7.1.107]"]
["ENSRNOG00000038413",0,0.042067634,51,3.280852347,0.012822166,-6.285216167,{"v":3.55857e-12,"d":"3.56E-12"},{"v":6.59043e-12,"d":"6.59E-12"},"down","yes","Olr1433","protein_coding","chr10:43037857-43046701:+","gi|47576039|ref|NP_001000525.1|",1491,0,"olfactory receptor Olr1433 [Rattus norvegicus]","gi|34849931|gb|AC109605.14|",1186,0,"Mus musculus strain 129S6/SvEvTac clone rp22-470o15 map 11, complete sequence","Q7Z3T1",459,{"v":7e-152,"d":"7.00E-152"},"Olfactory receptor 2W3",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0050911|detection of chemical stimulus involved in sensory perception of smell;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004984|olfactory receptor activity;","K04257","OLFR; olfactory receptor"]
["ENSRNOG00000022738",46,3.870222358,170,10.93617449,0.353891789,-1.498619805,{"v":3.96784e-12,"d":"3.97E-12"},{"v":7.32597e-12,"d":"7.33E-12"},"down","yes","AC098459.1","protein_coding","chr6:75727440-75728627:-","gi|564328458|ref|XP_006229294.1|",1580,0,"PREDICTED: L-lactate dehydrogenase A chain isoform X1 [Rattus norvegicus]","gi|197245746|gb|BC168737.1|",722,0,"Rattus norvegicus lactate dehydrogenase A, mRNA (cDNA clone MGC:188833 IMAGE:6917937), complete cds","P04642",597,0,"L-lactate dehydrogenase A chain","CAC0267",236,{"v":5E-74,"d":"5.00E-74"},"COG0039","pfam00056","Ldh_1_N","lactate/malate dehydrogenase, NAD binding domain. L-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate. The enzyme participates in the citric acid cycle. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes. N-terminus (this family) is a Rossmann NAD-binding fold. C-terminus is an unusual alpha+beta fold.",".",".",".",".","."]
["ENSRNOG00000003244",76,6.394280417,232,14.92466166,0.428437211,-1.222844307,{"v":3.98848e-12,"d":"3.99E-12"},{"v":7.36158e-12,"d":"7.36E-12"},"down","yes","Ltc4s","protein_coding","chr10:34560360-34562651:-","gi|148701763|gb|EDL33710.1|",574,{"v":4E-70,"d":"4.00E-70"},"leukotriene C4 synthase, isoform CRA_b [Mus musculus]","gi|672067209|ref|XM_008767655.1|",776,0,"PREDICTED: Rattus norvegicus leukotriene C4 synthase (Ltc4s), transcript variant X1, mRNA","Q925U2",220,{"v":3e-70,"d":"3.00E-70"},"Leukotriene C4 synthase",".",".",".",".","pfam01124","MAPEG","MAPEG family. This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolizm). It includes proteins such as Prostaglandin E synthase. This enzyme catalyses the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.","GO:0006691|leukotriene metabolic process;GO:0009410|response to xenobiotic stimulus;GO:0010035|response to inorganic substance;GO:0019370|leukotriene biosynthetic process;GO:0032496|response to lipopolysaccharide;GO:0042759|long-chain fatty acid biosynthetic process;GO:0048678|response to axon injury;GO:0050790|regulation of catalytic activity;GO:0071222|cellular response to lipopolysaccharide;GO:0071299|cellular response to vitamin A;GO:0098869|cellular oxidant detoxification;","GO:0005635|nuclear envelope;GO:0005640|nuclear outer membrane;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0031965|nuclear membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0004364|glutathione transferase activity;GO:0004464|leukotriene-C4 synthase activity;GO:0004602|glutathione peroxidase activity;GO:0008047|enzyme activator activity;GO:0008289|lipid binding;GO:0042802|identical protein binding;GO:0043295|glutathione binding;GO:0044877|protein-containing complex binding;","K00807","LTC4S; leukotriene-C4 synthase [EC:4.4.1.20]"]
["ENSRNOG00000003400",75,6.310145148,230,14.79600078,0.4264764,-1.229462186,{"v":4.0039e-12,"d":"4.00E-12"},{"v":7.38753e-12,"d":"7.39E-12"},"down","yes","Fmo4","protein_coding","chr13:75154684-75172874:-","gi|564381432|ref|XP_006250206.1|",2907,0,"PREDICTED: dimethylaniline monooxygenase [N-oxide-forming] 4 isoform X1 [Rattus norvegicus]","gi|402744366|ref|NM_144561.2|",2271,0,"Rattus norvegicus flavin containing monooxygenase 4 (Fmo4), transcript variant 2, mRNA","Q8K4B7",1124,0,"Dimethylaniline monooxygenase [N-oxide-forming] 4","CC0774",181,{"v":1e-48,"d":"1.00E-48"},"COG2072","pfam00743","FMO-like","Flavin-binding monooxygenase-like. This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.","GO:0042178|xenobiotic catabolic process;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0004497|monooxygenase activity;GO:0004499|N,N-dimethylaniline monooxygenase activity;GO:0050660|flavin adenine dinucleotide binding;GO:0050661|NADP binding;","K00485","FMO; dimethylaniline monooxygenase (N-oxide forming) / hypotaurine monooxygenase [EC:1.14.13.8 1.8.1.-]"]
["ENSRNOG00000017054",43,3.617816552,163,10.48586142,0.345018535,-1.535254225,{"v":4.64545e-12,"d":"4.65E-12"},{"v":8.51929e-12,"d":"8.52E-12"},"down","yes","ENSRNOG00000017054","lncRNA","chr1:154523830-154532020:+","gi|11596857|ref|NP_071571.1|",501,{"v":4e-56,"d":"4.00E-56"},"potassium voltage-gated channel subfamily E member 3 [Rattus norvegicus]","gi|32451509|gb|AC121350.2|",2257,0,"Rattus norvegicus chromosome 1 clone RP32-101I22 map q31-q35, complete sequence","Q9JJV7",197,{"v":1e-57,"d":"1.00E-57"},"Potassium voltage-gated channel subfamily E member 3",".",".",".",".","pfam02060","ISK_Channel","Slow voltage-gated potassium channel.","GO:0006814|sodium ion transport;GO:0030644|cellular chloride ion homeostasis;GO:0043266|regulation of potassium ion transport;GO:0060307|regulation of ventricular cardiac muscle cell membrane repolarization;GO:0071805|potassium ion transmembrane transport;GO:0086005|ventricular cardiac muscle cell action potential;GO:0086011|membrane repolarization during action potential;GO:0086091|regulation of heart rate by cardiac conduction;GO:0097623|potassium ion export across plasma membrane;GO:0098915|membrane repolarization during ventricular cardiac muscle cell action potential;GO:1901387|positive regulation of voltage-gated calcium channel activity;GO:1902260|negative regulation of delayed rectifier potassium channel activity;GO:1903765|negative regulation of potassium ion export across plasma membrane;GO:1903817|negative regulation of voltage-gated potassium channel activity;GO:1905025|negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0030425|dendrite;GO:0031982|vesicle;GO:0032809|neuronal cell body membrane;GO:0043204|perikaryon;GO:0045121|membrane raft;GO:1990794|basolateral part of cell;","GO:0005251|delayed rectifier potassium channel activity;GO:0005515|protein binding;GO:0015459|potassium channel regulator activity;GO:0044325|ion channel binding;GO:1902282|voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization;","K04897","KCNE3; potassium voltage-gated channel Isk-related subfamily E member 3"]
["ENSRNOG00000029427",10,0.841352686,81,5.210765493,0.161464316,-2.630712733,{"v":4.85907e-12,"d":"4.86E-12"},{"v":8.88709e-12,"d":"8.89E-12"},"down","yes","Grhl3","protein_coding","chr5:147774160-147806160:-","gi|672054381|ref|XP_008762438.1|",3152,0,"PREDICTED: grainyhead-like protein 3 homolog isoform X1 [Rattus norvegicus]","gi|672054380|ref|XM_008764216.1|",2641,0,"PREDICTED: Rattus norvegicus grainyhead-like 3 (Drosophila) (Grhl3), transcript variant X1, mRNA","Q5FWH3",1180,0,"Grainyhead-like protein 3 homolog",".",".",".",".","pfam04516","CP2","CP2 transcription factor. This family represents a conserved region in the CP2 transcription factor family.","GO:0001736|establishment of planar polarity;GO:0001843|neural tube closure;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007389|pattern specification process;GO:0007398|ectoderm development;GO:0007417|central nervous system development;GO:0008544|epidermis development;GO:0010628|positive regulation of gene expression;GO:0032956|regulation of actin cytoskeleton organization;GO:0042060|wound healing;GO:0043547|positive regulation of GTPase activity;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0061029|eyelid development in camera-type eye;GO:0061436|establishment of skin barrier;GO:0090103|cochlea morphogenesis;GO:0090179|planar cell polarity pathway involved in neural tube closure;","GO:0005634|nucleus;GO:0005654|nucleoplasm;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0031490|chromatin DNA binding;GO:0043565|sequence-specific DNA binding;","K09275","TFCP2; transcription factor CP2 and related proteins"]
["ENSRNOG00000010240",67,5.637062999,213,13.70238333,0.411392884,-1.281411255,{"v":5.36866e-12,"d":"5.37E-12"},{"v":9.78953e-12,"d":"9.79E-12"},"down","yes","Tent5a","protein_coding","chr8:86225357-86229045:-","gi|157820523|ref|NP_001100314.1|",2285,0,"protein FAM46A [Rattus norvegicus]","gi|157820522|ref|NM_001106844.1|",2474,0,"Rattus norvegicus family with sequence similarity 46, member A (Fam46a), mRNA","Q96IP4",807,0,"Terminal nucleotidyltransferase 5A",".",".",".",".","pfam07984","DUF1693","Domain of unknown function (DUF1693). This family contains many hypothetical proteins. It also includes four nematode prion-like proteins. This domain has been identified as part of the nucleotidyltransferase superfamily.","GO:0009617|response to bacterium;GO:0048255|mRNA stabilization;",".","GO:1990817|RNA adenylyltransferase activity;","K23033","TENT5A_B, FAM46A_B; terminal nucleotidyltransferase 5A/B [EC:2.7.7.-]"]
["ENSRNOG00000022635",7,0.588946881,71,4.567461111,0.128944038,-2.955183023,{"v":6.43659e-12,"d":"6.44E-12"},{"v":1.16821e-11,"d":"1.17E-11"},"down","yes","Dlg2","protein_coding","chr1:144451472-146499475:+","gi|589932495|ref|XP_006979045.1|",4423,0,"PREDICTED: disks large homolog 2-like isoform X2 [Peromyscus maniculatus bairdii]","gi|795347427|ref|XM_012075517.1|",2627,0,"PREDICTED: Cercocebus atys discs, large homolog 2 (Drosophila) (DLG2), transcript variant X14, mRNA","Q15700",1699,0,"Disks large homolog 2","YDR454c",102,{"v":1E-22,"d":"1.00E-22"},"COG0194","pfam00625","Guanylate_kin","Guanylate kinase.","GO:0007268|chemical synaptic transmission;GO:0009790|embryo development;GO:0019233|sensory perception of pain;GO:0035865|cellular response to potassium ion;GO:0043113|receptor clustering;GO:0045161|neuronal ion channel clustering;GO:0045197|establishment or maintenance of epithelial cell apical/basal polarity;GO:0097120|receptor localization to synapse;GO:0098609|cell-cell adhesion;GO:0099562|maintenance of postsynaptic density structure;GO:0099641|anterograde axonal protein transport;GO:0099642|retrograde axonal protein transport;GO:0099645|neurotransmitter receptor localization to postsynaptic specialization membrane;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0016323|basolateral plasma membrane;GO:0030054|cell junction;GO:0030425|dendrite;GO:0030672|synaptic vesicle membrane;GO:0031594|neuromuscular junction;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0044224|juxtaparanode region of axon;GO:0045211|postsynaptic membrane;GO:0098839|postsynaptic density membrane;GO:0098978|glutamatergic synapse;GO:0099031|anchored component of postsynaptic density membrane;GO:1904115|axon cytoplasm;","GO:0005515|protein binding;GO:0008022|protein C-terminus binding;GO:0019900|kinase binding;GO:0019903|protein phosphatase binding;GO:0030165|PDZ domain binding;GO:0044877|protein-containing complex binding;GO:0098919|structural constituent of postsynaptic density;","K12075","DLG2; discs large protein 2"]
["ENSRNOG00000031662",8,0.673082149,74,4.760452426,0.141390374,-2.822244191,{"v":7.18829e-12,"d":"7.19E-12"},{"v":1.30074E-11,"d":"1.30E-11"},"down","yes","Slc6a5","protein_coding","chr1:99645389-99697010:+","gi|978128196|sp|P58295.2|SC6A5_RAT",4048,0,"RecName: Full=Sodium- and chloride-dependent glycine transporter 2; Short=GlyT-2; Short=GlyT2; AltName: Full=Solute carrier family 6 member 5","gi|42627862|ref|NM_203334.1|",7029,0,"Rattus norvegicus solute carrier family 6 (neurotransmitter transporter), member 5 (Slc6a5), mRNA","P58295",1565,0,"Sodium- and chloride-dependent glycine transporter 2","BH3439",212,{"v":4e-57,"d":"4.00E-57"},"COG0733","pfam00209","SNF","Sodium:neurotransmitter symporter family.","GO:0001504|neurotransmitter uptake;GO:0015816|glycine transport;GO:0035725|sodium ion transmembrane transport;GO:0060012|synaptic transmission, glycinergic;GO:0098810|neurotransmitter reuptake;GO:1903804|glycine import across plasma membrane;","GO:0005768|endosome;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0031045|dense core granule;GO:0098690|glycinergic synapse;GO:0099056|integral component of presynaptic membrane;","GO:0015187|glycine transmembrane transporter activity;GO:0015375|glycine:sodium symporter activity;GO:0046872|metal ion binding;","K05038","SLC6A5_9, GLYT; solute carrier family 6 (neurotransmitter transporter, glycine) member 5/9"]
["ENSRNOG00000047706",73,6.141874611,224,14.41001815,0.426222545,-1.230321188,{"v":7.39919e-12,"d":"7.40E-12"},{"v":1.33756E-11,"d":"1.34E-11"},"down","yes","RT1-CE2","protein_coding","chr20:3537809-3541790:-","gi|57012402|ref|NP_001008840.1|",1652,0,"RT1 class I, locus CE2 precursor [Rattus norvegicus]","gi|110350025|gb|AC130591.5|",1653,0,"Rattus norvegicus BAC CH230-312A21 () complete sequence","P16391",528,{"v":2E-179,"d":"2.00E-179"},"RT1 class I histocompatibility antigen, AA alpha chain",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.",".",".",".",".","."]
["ENSRNOG00000026607",27,2.271652253,125,8.041304773,0.282497967,-1.823687608,{"v":7.72691e-12,"d":"7.73E-12"},{"v":1.39449E-11,"d":"1.39E-11"},"down","yes","Tnfsf18","protein_coding","chr13:73831252-73843169:+","gi|672027248|ref|XP_008760830.1|",867,{"v":1E-108,"d":"1.00E-108"},"PREDICTED: tumor necrosis factor ligand superfamily member 18 [Rattus norvegicus]","gi|672074632|ref|XM_008769705.1|",1924,0,"PREDICTED: Rattus norvegicus tumor necrosis factor (ligand) superfamily, member 18 (Tnfsf18), mRNA","Q7TS55",269,{"v":8e-84,"d":"8.00E-84"},"Tumor necrosis factor ligand superfamily member 18",".",".",".",".","pfam00229","TNF","TNF(tumor Necrosis Factor) family.","GO:0002309|T cell proliferation involved in immune response;GO:0002687|positive regulation of leukocyte migration;GO:0010759|positive regulation of macrophage chemotaxis;GO:0033209|tumor necrosis factor-mediated signaling pathway;GO:0042129|regulation of T cell proliferation;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0043254|regulation of protein complex assembly;GO:0045785|positive regulation of cell adhesion;GO:0050729|positive regulation of inflammatory response;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0090026|positive regulation of monocyte chemotaxis;GO:2000329|negative regulation of T-helper 17 cell lineage commitment;GO:2000508|regulation of dendritic cell chemotaxis;","GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0032813|tumor necrosis factor receptor superfamily binding;GO:0042802|identical protein binding;","K05479","TNFSF18, GITRL; tumor necrosis factor ligand superfamily member 18"]
["ENSRNOG00000052725",14,1.177893761,91,5.854069875,0.201209378,-2.313230543,{"v":1.01671E-11,"d":"1.02E-11"},{"v":1.81682e-11,"d":"1.82E-11"},"down","yes","Shisal1","protein_coding","chr7:115509035-115575449:-","gi|568993424|ref|XP_006521503.1|",876,{"v":1e-104,"d":"1.00E-104"},"PREDICTED: uncharacterized protein KIAA1644 isoform X2 [Mus musculus]","gi|672060434|ref|XR_593666.1|",3776,0,"PREDICTED: Rattus norvegicus similar to mKIAA1644 protein (RGD1566029), transcript variant X12, misc_RNA","Q0VBP7",320,{"v":2e-98,"d":"2.00E-98"},"Protein shisa-like-1",".",".",".",".","pfam13908","Shisa","Wnt and FGF inhibitory regulator. Shisa is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000006185",98,8.245256327,271,17.43354875,0.47295341,-1.080230023,{"v":1.12647e-11,"d":"1.13E-11"},{"v":2.00637E-11,"d":"2.01E-11"},"down","yes","Etaa1l1","protein_coding","chr14:92299553-92314104:-","gi|157819081|ref|NP_001102564.1|",3885,0,"Ewing tumor-associated antigen 1 [Rattus norvegicus]","gi|157819080|ref|NM_001109094.1|",2718,0,"Rattus norvegicus Ewing tumor-associated antigen 1 (Etaa1), mRNA","Q5SVT3",1187,0,"Ewing's tumor-associated antigen 1 homolog",".",".",".",".","pfam15350","ETAA1","Ewing's tumor-associated antigen 1 homologue. This family of proteins is found in eukaryotes, where members are expressed at high levels in the brain, liver kidney and Ewing tumor cell lines. Proteins in this family are typically between 648 and 898 amino acids in length.","GO:0006974|cellular response to DNA damage stimulus;GO:0031297|replication fork processing;GO:0071902|positive regulation of protein serine/threonine kinase activity;GO:2000001|regulation of DNA damage checkpoint;","GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0043596|nuclear replication fork;","GO:0043539|protein serine/threonine kinase activator activity;",".","."]
["ENSRNOG00000004810",92,7.740444715,258,16.59725305,0.466369025,-1.100456125,{"v":1.75692e-11,"d":"1.76E-11"},{"v":3.09484e-11,"d":"3.09E-11"},"down","yes","Plcb1","protein_coding","chr3:122060031-122772869:+","gi|117647200|ref|NP_001071109.1|",5081,0,"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [Rattus norvegicus]","gi|755498915|ref|XM_006498930.2|",4249,0,"PREDICTED: Mus musculus phospholipase C, beta 1 (Plcb1), transcript variant X1, mRNA","P10687",1961,0,"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1",".",".",".",".","pfam00388","PI-PLC-X","Phosphatidylinositol-specific phospholipase C, X domain. This associates with pfam00387 to form a single structural unit.","GO:0000086|G2/M transition of mitotic cell cycle;GO:0007213|G protein-coupled acetylcholine receptor signaling pathway;GO:0007215|glutamate receptor signaling pathway;GO:0007420|brain development;GO:0007612|learning;GO:0007613|memory;GO:0008277|regulation of G protein-coupled receptor signaling pathway;GO:0010243|response to organonitrogen compound;GO:0016042|lipid catabolic process;GO:0021987|cerebral cortex development;GO:0031161|phosphatidylinositol catabolic process;GO:0032735|positive regulation of interleukin-12 production;GO:0032957|inositol trisphosphate metabolic process;GO:0034284|response to monosaccharide;GO:0035556|intracellular signal transduction;GO:0035722|interleukin-12-mediated signaling pathway;GO:0035723|interleukin-15-mediated signaling pathway;GO:0040019|positive regulation of embryonic development;GO:0043434|response to peptide hormone;GO:0045444|fat cell differentiation;GO:0045663|positive regulation of myoblast differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0046330|positive regulation of JNK cascade;GO:0046488|phosphatidylinositol metabolic process;GO:0048009|insulin-like growth factor receptor signaling pathway;GO:0048015|phosphatidylinositol-mediated signaling;GO:0048639|positive regulation of developmental growth;GO:0050790|regulation of catalytic activity;GO:0051726|regulation of cell cycle;GO:0060466|activation of meiosis involved in egg activation;GO:0070498|interleukin-1-mediated signaling pathway;GO:0080154|regulation of fertilization;GO:0099170|postsynaptic modulation of chemical synaptic transmission;GO:0099178|regulation of retrograde trans-synaptic signaling by endocanabinoid;GO:1900087|positive regulation of G1/S transition of mitotic cell cycle;GO:1902618|cellular response to fluoride;GO:1903140|regulation of establishment of endothelial barrier;GO:1904117|cellular response to vasopressin;GO:1904637|cellular response to ionomycin;GO:1905631|cellular response to glyceraldehyde;GO:2000344|positive regulation of acrosome reaction;GO:2000438|negative regulation of monocyte extravasation;GO:2000560|positive regulation of CD24 biosynthetic process;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016020|membrane;GO:0016607|nuclear speck;GO:0031965|nuclear membrane;GO:0032991|protein-containing complex;GO:0098794|postsynapse;GO:0098978|glutamatergic synapse;GO:0098982|GABA-ergic synapse;","GO:0004435|phosphatidylinositol phospholipase C activity;GO:0005096|GTPase activator activity;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0005516|calmodulin binding;GO:0005521|lamin binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0019899|enzyme binding;GO:0042802|identical protein binding;","K05858","PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]"]
["ENSRNOG00000030688",72,6.057739343,219,14.08836596,0.429981686,-1.217652883,{"v":1.8444e-11,"d":"1.84E-11"},{"v":3.24265E-11,"d":"3.24E-11"},"down","yes","Lrrc2","protein_coding","chr8:110938165-110969185:+","gi|564365823|ref|XP_006243988.1|",1937,0,"PREDICTED: leucine-rich repeat-containing protein 2 isoform X1 [Rattus norvegicus]","gi|58865569|ref|NM_001012001.1|",2478,0,"Rattus norvegicus leucine rich repeat containing 2 (Lrrc2), mRNA","Q8VDB8",634,0,"Leucine-rich repeat-containing protein 2","MA2301_1",109,{"v":4e-25,"d":"4.00E-25"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0006470|protein dephosphorylation;GO:0007165|signal transduction;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0005737|cytoplasm;GO:0043231|intracellular membrane-bounded organelle;","GO:0004722|protein serine/threonine phosphatase activity;",".","."]
["ENSRNOG00000033335",43,3.617816552,159,10.22853967,0.353698247,-1.499409026,{"v":1.91046E-11,"d":"1.91E-11"},{"v":3.35121E-11,"d":"3.35E-11"},"down","yes","Cenpi","protein_coding","chrX:97515972-97567657:+","gi|564399935|ref|XP_006257277.1|",3685,0,"PREDICTED: centromere protein I isoform X1 [Rattus norvegicus]","gi|672088146|ref|XM_006257215.2|",3165,0,"PREDICTED: Rattus norvegicus centromere protein I (Cenpi), transcript variant X3, mRNA","Q63517",1402,0,"Centromere protein I",".",".",".",".","pfam07778","CENP-I","Mis6. Mis6 is an essential centromere connector protein acting during G1-S phase of the cell cycle. Mis6 is thought to be required for recruiting CENP-A, the centromere- specific histone H3 variant, an important event for centromere function and chromosome segregation during mitosis.","GO:0034508|centromere complex assembly;GO:0042699|follicle-stimulating hormone signaling pathway;","GO:0000776|kinetochore;GO:0005634|nucleus;GO:0005829|cytosol;GO:0016604|nuclear body;",".","K11501","CENPI; centromere protein I"]
["ENSRNOG00000030522",8,0.673082149,72,4.631791549,0.145317884,-2.782715827,{"v":1.92325E-11,"d":"1.92E-11"},{"v":3.37256e-11,"d":"3.37E-11"},"down","yes","ENSRNOG00000030522","protein_coding","chr4:162009857-162024625:+","gi|66730461|ref|NP_001019508.1|",1123,{"v":1e-149,"d":"1.00E-149"},"C-type lectin domain family 2 member D-related protein [Rattus norvegicus]","gi|66730460|ref|NM_001024337.1|",1434,0,"Rattus norvegicus similar to osteoclast inhibitory lectin (LOC500331), mRNA","Q5M9I1",437,{"v":5E-151,"d":"5.00E-151"},"C-type lectin domain family 2 member D-related protein",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type",".","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0030246|carbohydrate binding;GO:0046703|natural killer cell lectin-like receptor binding;",".","."]
["ENSRNOG00000043199",31,2.608193328,132,8.49161784,0.307149165,-1.702988634,{"v":2.00179e-11,"d":"2.00E-11"},{"v":3.50578e-11,"d":"3.51E-11"},"down","yes","Bves","protein_coding","chr20:48822308-48857472:+","gi|117606391|ref|NP_001071058.1|",1849,0,"blood vessel epicardial substance [Rattus norvegicus]","gi|117606390|ref|NM_001077590.1|",1471,0,"Rattus norvegicus blood vessel epicardial substance (Bves), mRNA","Q3BCU4",716,0,"Blood vessel epicardial substance",".",".",".",".","pfam04831","Popeye","Popeye protein conserved region. The function of Popeye proteins is not well understood. They are predominantly expressed in cardiac and skeletal muscle. This family represents a conserved region which includes three potential transmembrane domains.","GO:0001921|positive regulation of receptor recycling;GO:0002027|regulation of heart rate;GO:0002244|hematopoietic progenitor cell differentiation;GO:0002931|response to ischemia;GO:0007507|heart development;GO:0007519|skeletal muscle tissue development;GO:0008360|regulation of cell shape;GO:0016192|vesicle-mediated transport;GO:0034446|substrate adhesion-dependent cell spreading;GO:0040017|positive regulation of locomotion;GO:0042391|regulation of membrane potential;GO:0043087|regulation of GTPase activity;GO:0048278|vesicle docking;GO:0051146|striated muscle cell differentiation;GO:0060931|sinoatrial node cell development;GO:0060973|cell migration involved in heart development;GO:0090136|epithelial cell-cell adhesion;GO:2001135|regulation of endocytic recycling;","GO:0005886|plasma membrane;GO:0005901|caveola;GO:0005923|bicellular tight junction;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016328|lateral plasma membrane;GO:0030054|cell junction;GO:0031253|cell projection membrane;GO:0042383|sarcolemma;","GO:0005198|structural molecule activity;GO:0030552|cAMP binding;","K21108","BVES; blood vessel epicardial substance"]
["ENSRNOG00000013496",2,0.168270537,51,3.280852347,0.051288665,-4.285216167,{"v":2.01746e-11,"d":"2.02E-11"},{"v":3.53095e-11,"d":"3.53E-11"},"down","yes","Crisp3","protein_coding","chr9:20450908-20472658:+","gi|12408314|ref|NP_074050.1|",1130,{"v":2e-153,"d":"2.00E-153"},"cysteine-rich secretory protein 1 precursor [Rattus norvegicus]","gi|56112|emb|X04643.1|",864,0,"Rat mRNA for epididymal secretory glycoproteins","P12020",439,{"v":7e-155,"d":"7.00E-155"},"Cysteine-rich secretory protein 1",".",".",".",".","pfam08562","Crisp","Crisp. This domain is found on Crisp proteins which contain pfam00188 and has been termed the Crisp domain. It is found in the mammalian reproductive tract and the venom of reptiles, and has been shown to regulate ryanodine receptor Ca2+ signalling. It contains 10 conserved cysteines which are all involved in disulphide bonds and is structurally related to the ion channel inhibitor toxins BgK and ShK.",".","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0042581|specific granule;",".",".","."]
["ENSRNOG00000037082",2,0.168270537,51,3.280852347,0.051288665,-4.285216167,{"v":2.01746e-11,"d":"2.02E-11"},{"v":3.53095e-11,"d":"3.53E-11"},"down","yes","Mybphl","protein_coding","chr2:196005325-196018824:+","gi|62078815|ref|NP_001014064.1|",1842,0,"myosin-binding protein H-like [Rattus norvegicus]","gi|62078814|ref|NM_001014042.1|",1306,0,"Rattus norvegicus myosin binding protein H-like (Mybphl), mRNA","Q5PQM4",714,0,"Myosin-binding protein H-like",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0001701|in utero embryonic development;","GO:0030017|sarcomere;GO:0036379|myofilament;",".","K24494","MYBPH; myosin-binding protein H"]
["ENSRNOG00000008966",20,1.682705373,105,6.754696009,0.249116373,-2.005108248,{"v":2.34547e-11,"d":"2.35E-11"},{"v":4.08272e-11,"d":"4.08E-11"},"down","yes","Slco5a1","protein_coding","chr5:6228973-6352913:+","gi|564349979|ref|XP_006237805.1|",4201,0,"PREDICTED: solute carrier organic anion transporter family member 5A1 isoform X1 [Rattus norvegicus]","gi|157821922|ref|NM_001107898.1|",3177,0,"Rattus norvegicus solute carrier organic anion transporter family, member 5A1 (Slco5a1), mRNA","Q9H2Y9",1399,0,"Solute carrier organic anion transporter family member 5A1",".",".",".",".","pfam03137","OATP","Organic Anion Transporter Polypeptide (OATP) family. This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.","GO:0043252|sodium-independent organic anion transport;GO:0055085|transmembrane transport;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0015347|sodium-independent organic anion transmembrane transporter activity;","K14356","SLCO5A; solute carrier organic anion transporter family, member 5A"]
["ENSRNOG00000024043",67,5.637062999,208,13.38073114,0.421282136,-1.247141353,{"v":2.53507e-11,"d":"2.54E-11"},{"v":4.40289E-11,"d":"4.40E-11"},"down","yes","Orc6","protein_coding","chr19:21757866-21765662:-","gi|76096324|ref|NP_001028862.1|",1188,{"v":8e-159,"d":"8.00E-159"},"origin recognition complex subunit 6 [Rattus norvegicus]","gi|76096323|ref|NM_001033690.1|",1399,0,"Rattus norvegicus origin recognition complex, subunit 6 (Orc6), mRNA","Q9WUJ8",405,{"v":4e-138,"d":"4.00E-138"},"Origin recognition complex subunit 6",".",".",".",".","pfam05460","ORC6","Origin recognition complex subunit 6 (ORC6). This family consists of several eukaryotic origin recognition complex subunit 6 (ORC6) proteins. Despite differences in their structure and sequences among eukaryotic replicators, ORC is a conserved feature of replication initiation in all eukaryotes. ORC-related genes have been identified in organisms ranging from S. pombe to plants to humans. All DNA replication initiation is driven by a single conserved eukaryotic initiator complex termed he origin recognition complex (ORC). The ORC is a six protein complex. The function of ORC is reviewed in.","GO:0006261|DNA-dependent DNA replication;GO:0006270|DNA replication initiation;GO:0051782|negative regulation of cell division;","GO:0000808|origin recognition complex;GO:0001650|fibrillar center;GO:0005654|nucleoplasm;GO:0005664|nuclear origin of replication recognition complex;","GO:0003677|DNA binding;","K02608","ORC6; origin recognition complex subunit 6"]
["ENSRNOG00000011177",7,0.588946881,68,4.374469797,0.134632746,-2.892898744,{"v":2.87846e-11,"d":"2.88E-11"},{"v":4.97549e-11,"d":"4.98E-11"},"down","yes","Sftpc","protein_coding","chr15:45596574-45610777:-","gi|8394341|ref|NP_059038.1|",755,{"v":4E-95,"d":"4.00E-95"},"pulmonary surfactant-associated protein C precursor [Rattus norvegicus]","gi|62871619|gb|BC072693.1|",724,0,"Rattus norvegicus surfactant protein C, mRNA (cDNA clone MGC:91727 IMAGE:7099876), complete cds","P11685",295,{"v":1e-96,"d":"1.00E-96"},"Pulmonary surfactant-associated protein C",".",".",".",".","pfam08999","SP_C-Propep","Surfactant protein C, N terminal propeptide. The N-terminal propeptide of surfactant protein C adopts an alpha-helical structure, with turn and extended regions. It's main function is the stabilisation of metastable surfactant protein C (SP-C), since the latter can irreversibly transform from its native alpha-helical structure to beta-sheet aggregates and form amyloid-like fibrils. The correct intracellular trafficking of proSP-C has also been reported to depend on the propeptide.","GO:0007585|respiratory gaseous exchange;GO:0007623|circadian rhythm;GO:0009725|response to hormone;GO:0009749|response to glucose;GO:0010033|response to organic substance;GO:0032496|response to lipopolysaccharide;GO:0032526|response to retinoic acid;GO:0033189|response to vitamin A;GO:0050828|regulation of liquid surface tension;GO:0051384|response to glucocorticoid;GO:0051591|response to cAMP;GO:0055093|response to hyperoxia;GO:0070741|response to interleukin-6;GO:0070848|response to growth factor;GO:0071260|cellular response to mechanical stimulus;GO:0071732|cellular response to nitric oxide;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005771|multivesicular body;GO:0016021|integral component of membrane;GO:0097208|alveolar lamellar body;","GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000061450",67,5.637062999,207,13.3164007,0.423317316,-1.240188592,{"v":3.44572e-11,"d":"3.45E-11"},{"v":5.92216e-11,"d":"5.92E-11"},"down","yes","Homer2","protein_coding","chr1:135567414-135659772:-","gi|16758006|ref|NP_445761.1|",1876,0,"homer protein homolog 2 [Rattus norvegicus]","gi|16758005|ref|NM_053309.1|",1962,0,"Rattus norvegicus homer scaffolding protein 2 (Homer2), mRNA","O88801",727,0,"Homer protein homolog 2",".",".",".",".","pfam00568","WH1","WH1 domain. WASp Homology domain 1 (WH1) domain. WASP is the protein that is defective in Wiskott-Aldrich syndrome (WAS). The majority of point mutations occur within the amino- terminal WH1 domain. The metabotropic glutamate receptors mGluR1alpha and mGluR5 bind a protein called homer, which is a WH1 domain homologue. A subset of WH1 domains has been termed a \"EVH1\" domain and appear to bind a polyproline motif.","GO:0007216|G protein-coupled glutamate receptor signaling pathway;GO:0007605|sensory perception of sound;GO:0008277|regulation of G protein-coupled receptor signaling pathway;GO:0032703|negative regulation of interleukin-2 production;GO:0035584|calcium-mediated signaling using intracellular calcium source;GO:0048148|behavioral response to cocaine;GO:0048875|chemical homeostasis within a tissue;GO:0070885|negative regulation of calcineurin-NFAT signaling cascade;GO:2001256|regulation of store-operated calcium entry;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0030425|dendrite;GO:0032426|stereocilium tip;GO:0043025|neuronal cell body;GO:0043229|intracellular organelle;GO:0045177|apical part of cell;GO:0098978|glutamatergic synapse;","GO:0003779|actin binding;GO:0005515|protein binding;GO:0019904|protein domain specific binding;GO:0030160|GKAP/Homer scaffold activity;GO:0035254|glutamate receptor binding;GO:0035256|G protein-coupled glutamate receptor binding;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;","K15010","HOMER; homer"]
["ENSRNOG00000063398",0,0.042067634,46,2.959200157,0.01421588,-6.136352781,{"v":3.68792e-11,"d":"3.69E-11"},{"v":6.33243e-11,"d":"6.33E-11"},"down","yes","Nat8","protein_coding","chr4:118270954-118281763:-","gi|12018332|ref|NP_072157.1|",976,{"v":2E-116,"d":"2.00E-116"},"N-acetyltransferase 8 [Rattus norvegicus]","gi|746817484|ref|NR_130141.1|",1450,0,"Rattus norvegicus uncharacterized LOC100910827 (LOC100910827), long non-coding RNA","Q9QXT3",380,{"v":5e-118,"d":"5.00E-118"},"N-acetyltransferase 8",".",".",".",".","pfam00583","Acetyltransf_1","Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.",".",".",".",".","."]
["ENSRNOG00000005147",43,3.617816552,157,10.0998788,0.358203957,-1.481146819,{"v":3.84325e-11,"d":"3.84E-11"},{"v":6.58461e-11,"d":"6.58E-11"},"down","yes","Ccdc157","protein_coding","chr14:79014925-79031671:-","gi|564317275|ref|XP_002725035.2|",3378,0,"PREDICTED: coiled-coil domain-containing protein 157 [Rattus norvegicus]","gi|672028088|ref|XM_002724989.3|",2641,0,"PREDICTED: Rattus norvegicus coiled-coil domain containing 157 (Ccdc157), mRNA",".",".",".",".",".",".",".",".","pfam01576","Myosin_tail_1","Myosin tail. The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.",".",".",".",".","."]
["ENSRNOG00000070030",17,1.430299567,96,6.175722066,0.231600378,-2.110290485,{"v":4.01207e-11,"d":"4.01E-11"},{"v":6.85659E-11,"d":"6.86E-11"},"down","yes","ENSRNOG00000070030","lncRNA","chr1:73565662-73568411:+","gi|68063179|ref|XP_673599.1|",179,{"v":4e-12,"d":"4.00E-12"},"hypothetical protein [Plasmodium berghei strain ANKA] [Plasmodium berghei ANKA]","gi|354787663|gb|JN952164.1|",169,{"v":7e-81,"d":"7.00E-81"},"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Sort1:tm1e(EUCOMM)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices",".",".",".",".","."]
["ENSRNOG00000009700",6,0.504811612,64,4.117148044,0.122611965,-3.027828325,{"v":4.14105E-11,"d":"4.14E-11"},{"v":7.07078e-11,"d":"7.07E-11"},"down","yes","Dync1i1","protein_coding","chr4:33852927-34166149:+","gi|149064952|gb|EDM15028.1|",3249,0,"dynein cytoplasmic 1 intermediate chain 1, isoform CRA_c [Rattus norvegicus]","gi|11276090|ref|NM_019234.1|",2626,0,"Rattus norvegicus dynein cytoplasmic 1 intermediate chain 1 (Dync1i1), mRNA","Q63100",1249,0,"Cytoplasmic dynein 1 intermediate chain 1",".",".",".",".","pfam11540","Dynein_IC2","Cytoplasmic dynein 1 intermediate chain 2. Intermediate chain IC 2 forms part of the complex cytoplasmic dynein 1 along with a heavy chain (HC), two light intermediate chains (LICs) and three light chains (LCs). The complex is responsible for hydrolysing ATP to generate force toward the minus end of microtubules. IC binds to the HC via the N terminal binding domain on the HC and ICs contain binding sites for the LCs. The ICs are responsible for binding to kinetochores and the Golgi apparatus through an interaction with the p150Glued subunit of dynactin which is another complex.","GO:0007018|microtubule-based movement;GO:0007420|brain development;GO:0010970|transport along microtubule;GO:0047496|vesicle transport along microtubule;GO:0075733|intracellular transport of virus;","GO:0000776|kinetochore;GO:0000922|spindle pole;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005868|cytoplasmic dynein complex;GO:0005874|microtubule;GO:0031982|vesicle;GO:0036464|cytoplasmic ribonucleoprotein granule;GO:0048471|perinuclear region of cytoplasm;GO:0055037|recycling endosome;GO:1904115|axon cytoplasm;GO:1990257|piccolo-bassoon transport vesicle;","GO:0003777|microtubule motor activity;GO:0005515|protein binding;GO:0008017|microtubule binding;GO:0030507|spectrin binding;GO:0045503|dynein light chain binding;GO:0045504|dynein heavy chain binding;","K10415","DYNC1I, DNCI; dynein cytoplasmic 1 intermediate chain"]
["ENSRNOG00000067409",47,3.954357626,165,10.6145223,0.372542213,-1.424524188,{"v":4.65645e-11,"d":"4.66E-11"},{"v":7.92055e-11,"d":"7.92E-11"},"down","yes","Cfap299","protein_coding","chr14:10787203-11272943:-","gi|66841374|ref|NP_001019785.1|",1195,{"v":3e-163,"d":"3.00E-163"},"uncharacterized protein C4orf22 homolog [Mus musculus]","gi|66841373|ref|NM_001024614.1|",635,0,"Mus musculus RIKEN cDNA 1700007G11 gene (1700007G11Rik), mRNA",".",".",".",".",".",".",".",".","pfam14713","DUF4464","Domain of unknown function (DUF4464). This family of proteins is found in eukaryotes. Proteins in this family are typically between 224 and 241 amino acids in length. There is a conserved YID sequence motif.",".",".",".",".","."]
["ENSRNOG00000057760",63,5.300521925,198,12.73742676,0.416137578,-1.264867522,{"v":4.66521e-11,"d":"4.67E-11"},{"v":7.93048e-11,"d":"7.93E-11"},"down","yes","Stil","protein_coding","chr5:128520953-128573730:+","gi|672053541|ref|XP_008762197.1|",6232,0,"PREDICTED: SCL-interrupting locus protein isoform X2 [Rattus norvegicus]","gi|672053540|ref|XM_008763975.1|",4846,0,"PREDICTED: Rattus norvegicus Scl/Tal1 interrupting locus (Stil), transcript variant X2, mRNA","Q60988",2212,0,"SCL-interrupting locus protein homolog",".",".",".",".","pfam15253","STIL_N","SCL-interrupting locus protein N-terminus.","GO:0000578|embryonic axis specification;GO:0001701|in utero embryonic development;GO:0001843|neural tube closure;GO:0001947|heart looping;GO:0007052|mitotic spindle organization;GO:0007224|smoothened signaling pathway;GO:0007368|determination of left/right symmetry;GO:0008150|biological_process;GO:0021915|neural tube development;GO:0030900|forebrain development;GO:0030903|notochord development;GO:0033504|floor plate development;GO:0035264|multicellular organism growth;GO:0043066|negative regulation of apoptotic process;GO:0045737|positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0046599|regulation of centriole replication;GO:0051298|centrosome duplication;GO:0071539|protein localization to centrosome;GO:1905515|non-motile cilium assembly;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0005814|centriole;","GO:0003674|molecular_function;GO:0042802|identical protein binding;","K16724","STIL; SCL-interrupting locus protein"]
["ENSRNOG00000058870",63,5.300521925,198,12.73742676,0.416137578,-1.264867522,{"v":4.66521e-11,"d":"4.67E-11"},{"v":7.93048e-11,"d":"7.93E-11"},"down","yes","Mroh7","protein_coding","chr5:121463827-121503755:-","gi|155369285|ref|NP_001094435.1|",5360,0,"maestro heat-like repeat-containing protein family member 7 [Rattus norvegicus]","gi|402693335|ref|NM_001100965.2|",4160,0,"Rattus norvegicus maestro heat-like repeat family member 7 (Mroh7), mRNA","A2RUW0",2069,0,"Maestro heat-like repeat-containing protein family member 7",".",".",".",".","pfam10468","Inhibitor_I68","Carboxypeptidase inhibitor I68. This is a family of tick carboxypetidase inhibitors.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000070554",11,0.925487955,79,5.082104617,0.182107222,-2.457139955,{"v":5.09332e-11,"d":"5.09E-11"},{"v":8.63666e-11,"d":"8.64E-11"},"down","yes","ENSRNOG00000070554","lncRNA","chr1:23123683-23127067:-","gi|149028494|gb|EDL83879.1|",225,{"v":8e-20,"d":"8.00E-20"},"rCG22859 [Rattus norvegicus]","gi|27545029|gb|AC091712.3|",734,0,"Rattus norvegicus strain Brown Norway clone RP31-64M17, complete sequence",".",".",".",".",".",".",".",".","pfam02093","Gag_p30","Gag P30 core shell protein. According to Swiss-Prot annotation this protein is the viral core shell protein. P30 is essential for viral assembly.",".",".",".",".","."]
["ENSRNOG00000005359",50,4.206763432,171,11.00050493,0.382415485,-1.38678715,{"v":5.18854e-11,"d":"5.19E-11"},{"v":8.79539e-11,"d":"8.80E-11"},"down","yes","Csrnp3","protein_coding","chr3:50498633-50685950:+","gi|148695060|gb|EDL27007.1|",2587,0,"RIKEN cDNA A330102K23, partial [Mus musculus]","gi|403420593|ref|NM_001271225.1|",2535,0,"Rattus norvegicus cysteine-serine-rich nuclear protein 3 (Csrnp3), mRNA","P59055",986,0,"Cysteine/serine-rich nuclear protein 3",".",".",".",".","pfam01500","Keratin_B2","Keratin, high sulfur B2 protein. High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0043065|positive regulation of apoptotic process;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0043565|sequence-specific DNA binding;","K17494","CSRNP; cysteine/serine-rich nuclear protein"]
["ENSRNOG00000019582",107,9.002473745,282,18.14118357,0.496245116,-1.010875191,{"v":5.40011e-11,"d":"5.40E-11"},{"v":9.14266e-11,"d":"9.14E-11"},"down","yes","Mthfd1l","protein_coding","chr1:40444008-40632905:+","gi|313151179|ref|NP_001101932.2|",4876,0,"monofunctional C1-tetrahydrofolate synthase, mitochondrial [Rattus norvegicus]","gi|313151178|ref|NM_001108462.2|",3522,0,"Rattus norvegicus methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (Mthfd1l), mRNA","Q3V3R1",1788,0,"Monofunctional C1-tetrahydrofolate synthase, mitochondrial","SPBC839.16_2",699,0,"COG2759","pfam01268","FTHFS","Formate--tetrahydrofolate ligase.","GO:0001843|neural tube closure;GO:0006760|folic acid-containing compound metabolic process;GO:0008150|biological_process;GO:0009257|10-formyltetrahydrofolate biosynthetic process;GO:0015942|formate metabolic process;GO:0035999|tetrahydrofolate interconversion;GO:0048702|embryonic neurocranium morphogenesis;GO:0048703|embryonic viscerocranium morphogenesis;","GO:0005575|cellular_component;GO:0005739|mitochondrion;GO:0005829|cytosol;","GO:0003674|molecular_function;GO:0004329|formate-tetrahydrofolate ligase activity;GO:0004488|methylenetetrahydrofolate dehydrogenase (NADP+) activity;GO:0005524|ATP binding;GO:0042803|protein homodimerization activity;","K13402","MTHFD1L; monofunctional C1-tetrahydrofolate synthase, mitochondrial [EC:6.3.4.3]"]
["ENSRNOG00000015465",90,7.572174178,250,16.08260955,0.470829946,-1.086722014,{"v":5.64712e-11,"d":"5.65E-11"},{"v":9.54633e-11,"d":"9.55E-11"},"down","yes","Cep72","protein_coding","chr1:29225361-29255271:+","gi|109457649|ref|XP_217737.4|",3272,0,"PREDICTED: centrosomal protein of 72 kDa isoform X4 [Rattus norvegicus]","gi|672012596|ref|XM_001056326.5|",2447,0,"PREDICTED: Rattus norvegicus centrosomal protein 72 (Cep72), transcript variant X4, mRNA","Q9D3R3",1167,0,"Centrosomal protein of 72 kDa",".",".",".",".","pfam14580","LRR_9","Leucine-rich repeat.","GO:0007051|spindle organization;GO:0007099|centriole replication;GO:0033566|gamma-tubulin complex localization;GO:1904779|regulation of protein localization to centrosome;","GO:0005813|centrosome;GO:0034451|centriolar satellite;","GO:0042802|identical protein binding;","K16532","CEP72; centrosomal protein CEP72"]
["ENSRNOG00000002653",76,6.394280417,223,14.34568772,0.445728399,-1.165763212,{"v":5.80586e-11,"d":"5.81E-11"},{"v":9.80522e-11,"d":"9.81E-11"},"down","yes","Kcnk2","protein_coding","chr13:100766113-100963435:-","gi|25282471|ref|NP_742039.1|",2196,0,"potassium channel subfamily K member 2 isoform 2 [Rattus norvegicus]","gi|25282470|ref|NM_172042.1|",3121,0,"Rattus norvegicus potassium two pore domain channel subfamily K member 2 (Kcnk2), transcript variant 2, mRNA","Q920B6",849,0,"Potassium channel subfamily K member 2","MA2218",49.3,7e-06,"COG1226","pfam07885","Ion_trans_2","Ion channel. This family includes the two membrane helix type ion channels found in bacteria.","GO:0003231|cardiac ventricle development;GO:0006813|potassium ion transport;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007613|memory;GO:0009612|response to mechanical stimulus;GO:0010942|positive regulation of cell death;GO:0030322|stabilization of membrane potential;GO:0042391|regulation of membrane potential;GO:0048678|response to axon injury;GO:0060044|negative regulation of cardiac muscle cell proliferation;GO:0071456|cellular response to hypoxia;GO:0071805|potassium ion transmembrane transport;GO:0090102|cochlea development;GO:1900039|positive regulation of cellular response to hypoxia;GO:2000279|negative regulation of DNA biosynthetic process;","GO:0005634|nucleus;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0008076|voltage-gated potassium channel complex;GO:0009986|cell surface;GO:0016324|apical plasma membrane;GO:0030424|axon;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043679|axon terminus;GO:0044305|calyx of Held;GO:0097449|astrocyte projection;","GO:0005249|voltage-gated potassium channel activity;GO:0005515|protein binding;GO:0015271|outward rectifier potassium channel activity;GO:0019870|potassium channel inhibitor activity;GO:0022841|potassium ion leak channel activity;","K04913","KCNK2, K2P2.1; potassium channel subfamily K member 2"]
["ENSRNOG00000004412",46,3.870222358,162,10.42153099,0.371367927,-1.429078872,{"v":6.27196e-11,"d":"6.27E-11"},{"v":1.05662E-10,"d":"1.06E-10"},"down","yes","Mtbp","protein_coding","chr7:86973069-87050827:+","gi|195539325|ref|NP_001124189.1|",4759,0,"mdm2-binding protein [Rattus norvegicus]","gi|195539324|ref|NM_001130717.1|",3294,0,"Rattus norvegicus MDM2 binding protein (Mtbp), mRNA","Q8BJS8",1691,0,"Mdm2-binding protein",".",".",".",".","pfam14919","MTBP_mid","MDM2-binding. MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its interaction with p53, plays an important role in the regulation of the G1 checkpoint of the cell cycle. MTBP promotes MDM2-mediated ubiquitination and degradation of p53 and also MDM2 stabilisation in an MDM2 RING finger-dependent manner. MTBP differentially regulates the E3 ubiquitin ligase activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells. MTBP inhibits cancer cell migration by interacting with a protein involved in cell motility. This motility protein is alpha-actinin-4 (ACTN4). It is unclear which regions of MTBP interact with which binding-partner. See PF14918, PF14920.","GO:0007089|traversing start control point of mitotic cell cycle;GO:0008285|negative regulation of cell proliferation;GO:0031396|regulation of protein ubiquitination;GO:0034501|protein localization to kinetochore;GO:0045839|negative regulation of mitotic nuclear division;","GO:0000776|kinetochore;GO:0000785|chromatin;",".",".","."]
["ENSRNOG00000011841",81,6.81495676,232,14.92466166,0.45662387,-1.130921818,{"v":7.07286e-11,"d":"7.07E-11"},{"v":1.18787e-10,"d":"1.19E-10"},"down","yes","Map2","protein_coding","chr9:67723371-67979809:+","gi|672065487|ref|XP_008765425.1|",7966,0,"PREDICTED: microtubule-associated protein 2 isoform X6 [Rattus norvegicus]","gi|672065486|ref|XM_008767203.1|",5426,0,"PREDICTED: Rattus norvegicus microtubule-associated protein 2 (Map2), transcript variant X7, mRNA","P15146",2900,0,"Microtubule-associated protein 2",".",".",".",".","pfam08377","MAP2_projctn","MAP2/Tau projection domain. This domain is found in the MAP2/Tau family of proteins which includes MAP2, MAP4, Tau, and their homologs. All isoforms contain a conserved C-terminal domain containing tubulin-binding repeats (pfam00418), and a N-terminal projection domain of varying size. This domain has a net negative charge and exerts a long-range repulsive force. This provides a mechanism that can regulate microtubule spacing which might facilitate efficient organelle transport.","GO:0000226|microtubule cytoskeleton organization;GO:0001578|microtubule bundle formation;GO:0007026|negative regulation of microtubule depolymerization;GO:0007409|axonogenesis;GO:0016358|dendrite development;GO:0021954|central nervous system neuron development;GO:0030010|establishment of cell polarity;GO:0030517|negative regulation of axon extension;GO:0031115|negative regulation of microtubule polymerization;GO:0031175|neuron projection development;GO:0032355|response to estradiol;GO:0032570|response to progesterone;GO:0048813|dendrite morphogenesis;GO:0071310|cellular response to organic substance;GO:1901953|positive regulation of anterograde dense core granule transport;GO:1902513|regulation of organelle transport along microtubule;GO:1903744|positive regulation of anterograde synaptic vesicle transport;GO:1903827|regulation of cellular protein localization;GO:1904527|negative regulation of microtubule binding;","GO:0005737|cytoplasm;GO:0005790|smooth endoplasmic reticulum;GO:0005791|rough endoplasmic reticulum;GO:0005874|microtubule;GO:0014069|postsynaptic density;GO:0015629|actin cytoskeleton;GO:0015630|microtubule cytoskeleton;GO:0030424|axon;GO:0030425|dendrite;GO:0032587|ruffle membrane;GO:0032839|dendrite cytoplasm;GO:0032991|protein-containing complex;GO:0034399|nuclear periphery;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043194|axon initial segment;GO:0043198|dendritic shaft;GO:0043203|axon hillock;GO:0044294|dendritic growth cone;GO:0044297|cell body;GO:0044307|dendritic branch;GO:0097440|apical dendrite;GO:0097441|basal dendrite;GO:0097442|CA3 pyramidal cell dendrite;GO:0150001|primary dendrite;GO:0150002|distal dendrite;GO:0150014|apical distal dendrite;GO:1902737|dendritic filopodium;GO:1990635|proximal dendrite;GO:1990769|proximal neuron projection;","GO:0002162|dystroglycan binding;GO:0003779|actin binding;GO:0005515|protein binding;GO:0005516|calmodulin binding;GO:0008017|microtubule binding;GO:0015631|tubulin binding;GO:0019901|protein kinase binding;","K10430","MAP2; microtubule-associated protein 2"]
["ENSRNOG00000005376",99,8.329391596,264,16.98323568,0.49044786,-1.027828325,{"v":1.24146E-10,"d":"1.24E-10"},{"v":2.05146E-10,"d":"2.05E-10"},"down","yes","Mad2l1","protein_coding","chr4:95906817-95913470:+","gi|148666370|gb|EDK98786.1|",1096,{"v":8e-145,"d":"8.00E-145"},"mCG125314, isoform CRA_b, partial [Mus musculus]","gi|157819416|ref|NM_001106594.1|",1280,0,"Rattus norvegicus MAD2 mitotic arrest deficient-like 1 (yeast) (Mad2l1), mRNA","Q9Z1B5",410,{"v":3e-140,"d":"3.00E-140"},"Mitotic spindle assembly checkpoint protein MAD2A",".",".",".",".","pfam02301","HORMA","HORMA domain. The HORMA (for Hop1p, Rev7p and MAD2) domain has been suggested to recognize chromatin states that result from DNA adducts, double stranded breaks or non-attachment to the spindle and acts as an adaptor that recruits other proteins. MAD2 is a spindle checkpoint protein which prevents progression of the cell cycle upon detection of a defect in mitotic spindle integrity.","GO:0000070|mitotic sister chromatid segregation;GO:0000132|establishment of mitotic spindle orientation;GO:0007094|mitotic spindle assembly checkpoint;GO:0042177|negative regulation of protein catabolic process;GO:0043066|negative regulation of apoptotic process;GO:0045930|negative regulation of mitotic cell cycle;GO:0051660|establishment of centrosome localization;GO:0090267|positive regulation of mitotic cell cycle spindle assembly checkpoint;GO:1904667|negative regulation of ubiquitin protein ligase activity;","GO:0000775|chromosome, centromeric region;GO:0000776|kinetochore;GO:0000922|spindle pole;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005694|chromosome;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0044615|nuclear pore nuclear basket;GO:0048471|perinuclear region of cytoplasm;GO:0072686|mitotic spindle;","GO:0008022|protein C-terminus binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;","K02537","MAD2; mitotic spindle assembly checkpoint protein MAD2"]
["ENSRNOG00000048193",91,7.656309447,249,16.01827911,0.477973283,-1.064998117,{"v":1.25015e-10,"d":"1.25E-10"},{"v":2.06519e-10,"d":"2.07E-10"},"down","yes","Hnrnph3","protein_coding","chr20:25614733-25625750:+","gi|767962730|ref|XP_011538044.1|",605,{"v":2e-67,"d":"2.00E-67"},"PREDICTED: heterogeneous nuclear ribonucleoprotein H3 isoform X3 [Homo sapiens]","gi|672086235|ref|XM_006256376.2|",1791,0,"PREDICTED: Rattus norvegicus heterogeneous nuclear ribonucleoprotein H3 (2H9) (Hnrnph3), transcript variant X1, mRNA","P31942",177,{"v":2E-46,"d":"2.00E-46"},"Heterogeneous nuclear ribonucleoprotein H3","YJL177w",56.2,7e-08,"COG0091","pfam14259","RRM_6","RNA recognition motif (a.k.a. RRM, RBD, or RNP domain).","GO:0008150|biological_process;GO:0030855|epithelial cell differentiation;GO:0043484|regulation of RNA splicing;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:1990904|ribonucleoprotein complex;","GO:0003674|molecular_function;GO:0003723|RNA binding;","K12898","HNRNPF_H; heterogeneous nuclear ribonucleoprotein F/H"]
["ENSRNOG00000012438",21,1.766840642,103,6.626035133,0.266651264,-1.90697393,{"v":1.52559e-10,"d":"1.53E-10"},{"v":2.50425e-10,"d":"2.50E-10"},"down","yes","Larp6","protein_coding","chr8:61184116-61205535:+","gi|157822983|ref|NP_001101624.1|",2378,0,"la-related protein 6 [Rattus norvegicus]","gi|157822982|ref|NM_001108154.1|",2336,0,"Rattus norvegicus La ribonucleoprotein domain family, member 6 (Larp6), mRNA","Q8BN59",840,0,"La-related protein 6",".",".",".",".","pfam05383","La","La domain. This presumed domain is found at the N-terminus of La RNA-binding proteins as well as other proteins. The function of this region is uncertain.","GO:0006396|RNA processing;GO:0032967|positive regulation of collagen biosynthetic process;GO:0045727|positive regulation of translation;GO:1902416|positive regulation of mRNA binding;","GO:0005634|nucleus;GO:0005844|polysome;GO:1990904|ribonucleoprotein complex;","GO:0017022|myosin binding;GO:0035613|RNA stem-loop binding;GO:0048027|mRNA 5'-UTR binding;GO:1990825|sequence-specific mRNA binding;","K18733","LARP6; la-related protein 6"]
["ENSRNOG00000051405",30,2.524058059,124,7.976974335,0.316417974,-1.66009654,{"v":1.73567E-10,"d":"1.74E-10"},{"v":2.84053e-10,"d":"2.84E-10"},"down","yes","AABR07021465.1","protein_coding","chr13:68458411-68544172:-","gi|672027354|ref|XP_008761118.1|",4258,0,"PREDICTED: axonemal dynein light chain domain-containing protein 1 isoform X1 [Rattus norvegicus]","gi|755471695|ref|XM_011251715.1|",2153,0,"PREDICTED: Mus musculus axonemal dynein light chain domain containing 1 (Axdnd1), mRNA",".",".",".",".",".",".",".",".","pfam10211","Ax_dynein_light","Axonemal dynein light chain. Axonemal dynein light chain proteins play a dynamic role in flagellar and cilia motility. Eukaryotic cilia and flagella are complex organelles consisting of a core structure, the axoneme, which is composed of nine microtubule doublets forming a cylinder that surrounds a pair of central singlet microtubules. This ultra-structural arrangement seems to be one of the most stable micro-tubular assemblies known and is responsible for the flagellar and ciliary movement of a large number of organisms ranging from protozoan to mammals. This light chain interacts directly with the N-terminal half of the heavy chains.",".",".",".",".","."]
["ENSRNOG00000039949",78,6.562550954,223,14.34568772,0.457458094,-1.128288506,{"v":1.77746E-10,"d":"1.78E-10"},{"v":2.9063e-10,"d":"2.91E-10"},"down","yes","Rad54b","protein_coding","chr5:25032066-25104616:+","gi|564350366|ref|XP_006237952.1|",4509,0,"PREDICTED: fibrinogen silencer-binding protein isoform X1 [Rattus norvegicus]","gi|672051958|ref|XM_006237890.2|",2822,0,"PREDICTED: Rattus norvegicus RAD54 homolog B (S. cerevisiae) (Rad54b), transcript variant X1, mRNA","Q6PFE3",1527,0,"DNA repair and recombination protein RAD54B","SPAC15A10.03c",471,{"v":8e-150,"d":"8.00E-150"},"COG0553","pfam00176","SNF2_N","SNF2 family N-terminal domain. This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1).","GO:0000724|double-strand break repair via homologous recombination;GO:0006974|cellular response to DNA damage stimulus;GO:0007131|reciprocal meiotic recombination;GO:0008150|biological_process;GO:0008340|determination of adult lifespan;GO:0009410|response to xenobiotic stimulus;GO:0010212|response to ionizing radiation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;","GO:0003674|molecular_function;GO:0005524|ATP binding;GO:0015616|DNA translocase activity;GO:0042802|identical protein binding;","K10877","RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]"]
["ENSRNOG00000006003",92,7.740444715,249,16.01827911,0.483225736,-1.049230801,{"v":2.08138E-10,"d":"2.08E-10"},{"v":3.39e-10,"d":"3.39E-10"},"down","yes","Ctnna2","protein_coding","chr4:109293978-110443522:-","gi|821013078|ref|XP_004090482.2|",4782,0,"PREDICTED: catenin alpha-2 isoform X1 [Nomascus leucogenys]","gi|157817080|ref|NM_001106598.1|",4084,0,"Rattus norvegicus catenin alpha 2 (Ctnna2), mRNA","Q61301",1845,0,"Catenin alpha-2",".",".",".",".","pfam01044","Vinculin","Vinculin family.","GO:0007409|axonogenesis;GO:0010975|regulation of neuron projection development;GO:0016477|cell migration;GO:0021942|radial glia guided migration of Purkinje cell;GO:0034316|negative regulation of Arp2/3 complex-mediated actin nucleation;GO:0048813|dendrite morphogenesis;GO:0048854|brain morphogenesis;GO:0051823|regulation of synapse structural plasticity;GO:0060134|prepulse inhibition;GO:0098609|cell-cell adhesion;GO:0098885|modification of postsynaptic actin cytoskeleton;GO:2001222|regulation of neuron migration;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005912|adherens junction;GO:0014069|postsynaptic density;GO:0016323|basolateral plasma membrane;GO:0016342|catenin complex;GO:0030027|lamellipodium;GO:0030424|axon;GO:0098686|hippocampal mossy fiber to CA3 synapse;GO:0098688|parallel fiber to Purkinje cell synapse;GO:0098831|presynaptic active zone cytoplasmic component;GO:0098888|extrinsic component of presynaptic membrane;GO:0098890|extrinsic component of postsynaptic membrane;GO:0099092|postsynaptic density, intracellular component;","GO:0008013|beta-catenin binding;GO:0042802|identical protein binding;GO:0045296|cadherin binding;GO:0051015|actin filament binding;","K05691","CTNNA; catenin alpha"]
["ENSRNOG00000007597",63,5.300521925,193,12.41577457,0.426918344,-1.227967939,{"v":2.17383E-10,"d":"2.17E-10"},{"v":3.5374e-10,"d":"3.54E-10"},"down","yes","Rhpn1","protein_coding","chr7:107391984-107402713:+","gi|765099162|ref|NP_001292166.1|",3366,0,"rhophilin-1 [Rattus norvegicus]","gi|765099161|ref|NM_001305237.1|",3337,0,"Rattus norvegicus rhophilin, Rho GTPase binding protein 1 (Rhpn1), mRNA","Q61085",1163,0,"Rhophilin-1",".",".",".",".","pfam03097","BRO1","BRO1-like domain. This domain is found in a number proteins including Rhophilin and BRO1. It is known to have a role in endosomal targeting. ESCRT-III subunit Snf7 binds to a conserved hydrophobic patch in the BRO1 domain that is required for protein complex formation and for the protein-sorting function of BRO1.","GO:0001822|kidney development;GO:0003094|glomerular filtration;GO:0007165|signal transduction;GO:0048041|focal adhesion assembly;GO:0051497|negative regulation of stress fiber assembly;GO:0097018|renal albumin absorption;GO:0120039|plasma membrane bounded cell projection morphogenesis;","GO:0005886|plasma membrane;GO:0071944|cell periphery;",".","K25638","RHPN1; rhophilin-1"]
["ENSRNOG00000010853",9,0.757217418,70,4.503130673,0.168153552,-2.572148841,{"v":2.23273E-10,"d":"2.23E-10"},{"v":3.63001E-10,"d":"3.63E-10"},"down","yes","Chrna7","protein_coding","chr1:116714711-116837240:-","gi|144922602|ref|NP_036964.3|",2475,0,"neuronal acetylcholine receptor subunit alpha-7 precursor [Rattus norvegicus]","gi|3478618|gb|L31619.1|RATNARAD",2080,0,"Rattus rattus nicotinic acetylcholine receptor alpha 7 subunit mRNA, complete cds","Q05941",954,0,"Neuronal acetylcholine receptor subunit alpha-7",".",".",".",".","pfam02931","Neur_chan_LBD","Neurotransmitter-gated ion-channel ligand binding domain. This family is the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.","GO:0001666|response to hypoxia;GO:0001933|negative regulation of protein phosphorylation;GO:0001934|positive regulation of protein phosphorylation;GO:0001988|positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure;GO:0006811|ion transport;GO:0006816|calcium ion transport;GO:0006874|cellular calcium ion homeostasis;GO:0006897|endocytosis;GO:0007165|signal transduction;GO:0007268|chemical synaptic transmission;GO:0007271|synaptic transmission, cholinergic;GO:0007611|learning or memory;GO:0007613|memory;GO:0008284|positive regulation of cell proliferation;GO:0008306|associative learning;GO:0009409|response to cold;GO:0014061|regulation of norepinephrine secretion;GO:0019228|neuronal action potential;GO:0030317|flagellated sperm motility;GO:0032094|response to food;GO:0032225|regulation of synaptic transmission, dopaminergic;GO:0032691|negative regulation of interleukin-1 beta production;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0034220|ion transmembrane transport;GO:0035094|response to nicotine;GO:0035095|behavioral response to nicotine;GO:0042110|T cell activation;GO:0042113|B cell activation;GO:0042391|regulation of membrane potential;GO:0042416|dopamine biosynthetic process;GO:0042698|ovulation cycle;GO:0043410|positive regulation of MAPK cascade;GO:0045471|response to ethanol;GO:0045766|positive regulation of angiogenesis;GO:0048149|behavioral response to ethanol;GO:0050727|regulation of inflammatory response;GO:0050728|negative regulation of inflammatory response;GO:0050804|modulation of chemical synaptic transmission;GO:0050808|synapse organization;GO:0050877|nervous system process;GO:0050890|cognition;GO:0050893|sensory processing;GO:0051247|positive regulation of protein metabolic process;GO:0060079|excitatory postsynaptic potential;GO:0060112|generation of ovulation cycle rhythm;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0095500|acetylcholine receptor signaling pathway;GO:0097061|dendritic spine organization;GO:0098815|modulation of excitatory postsynaptic potential;GO:0140059|dendrite arborization;GO:1900273|positive regulation of long-term synaptic potentiation;GO:1901214|regulation of neuron death;GO:1902004|positive regulation of amyloid-beta formation;GO:1902430|negative regulation of amyloid-beta formation;GO:1902991|regulation of amyloid precursor protein catabolic process;GO:1904645|response to amyloid-beta;GO:1905144|response to acetylcholine;GO:1905906|regulation of amyloid fibril formation;GO:1905920|positive regulation of CoA-transferase activity;GO:2000300|regulation of synaptic vesicle exocytosis;GO:2000463|positive regulation of excitatory postsynaptic potential;GO:2001023|regulation of response to drug;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005892|acetylcholine-gated channel complex;GO:0009897|external side of plasma membrane;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0030426|growth cone;GO:0030673|axolemma;GO:0032279|asymmetric synapse;GO:0042734|presynaptic membrane;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043197|dendritic spine;GO:0043198|dendritic shaft;GO:0044853|plasma membrane raft;GO:0045121|membrane raft;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0098690|glycinergic synapse;GO:0098981|cholinergic synapse;GO:0099055|integral component of postsynaptic membrane;GO:0099056|integral component of presynaptic membrane;GO:0099060|integral component of postsynaptic specialization membrane;GO:0099065|integral component of spine apparatus membrane;","GO:0001540|amyloid-beta binding;GO:0004888|transmembrane signaling receptor activity;GO:0005216|ion channel activity;GO:0005515|protein binding;GO:0008179|adenylate cyclase binding;GO:0015464|acetylcholine receptor activity;GO:0015643|toxic substance binding;GO:0017081|chloride channel regulator activity;GO:0019901|protein kinase binding;GO:0022848|acetylcholine-gated cation-selective channel activity;GO:0030594|neurotransmitter receptor activity;GO:0042166|acetylcholine binding;GO:0042803|protein homodimerization activity;GO:0051117|ATPase binding;GO:0097110|scaffold protein binding;GO:1904315|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K04809","CHRNA7; nicotinic acetylcholine receptor alpha-7"]
["ENSRNOG00000000201",13,1.093758492,81,5.210765493,0.209903611,-2.25220111,{"v":2.67599e-10,"d":"2.68E-10"},{"v":4.31459e-10,"d":"4.31E-10"},"down","yes","Gsta5","protein_coding","chr8:79105661-79117472:+","gi|58331251|ref|NP_001010921.1|",1171,{"v":3E-160,"d":"3.00E-160"},"glutathione S-transferase alpha-2 [Rattus norvegicus]","gi|672061818|ref|XM_006243421.2|",830,0,"PREDICTED: Rattus norvegicus glutathione S-transferase alpha 2 (Gsta2), transcript variant X1, mRNA","P04903",452,{"v":1e-160,"d":"1.00E-160"},"Glutathione S-transferase alpha-2","AGc1530",52.8,2e-07,"COG0625","pfam00043","GST_C","Glutathione S-transferase, C-terminal domain. GST conjugates reduced glutathione to a variety of targets including S-crystallin from squid, the eukaryotic elongation factor 1-gamma, the HSP26 family of stress-related proteins and auxin-regulated proteins in plants. Stringent starvation proteins in Escherichia coli are also included in the alignment but are not known to have GST activity.     The glutathione molecule binds in a cleft between N and C-terminal domains. The catalytically important residues are proposed to reside in the N-terminal domain. In plants, GSTs are encoded by a large gene family (48 GST genes in Arabidopsis) and can be divided into the phi, tau, theta, zeta, and lambda classes.","GO:0006693|prostaglandin metabolic process;GO:0006749|glutathione metabolic process;GO:0006805|xenobiotic metabolic process;GO:0007568|aging;GO:0009617|response to bacterium;GO:0030855|epithelial cell differentiation;GO:0035634|response to stilbenoid;GO:0042178|xenobiotic catabolic process;GO:0098869|cellular oxidant detoxification;GO:1901687|glutathione derivative biosynthetic process;","GO:0005829|cytosol;","GO:0004364|glutathione transferase activity;GO:0004769|steroid delta-isomerase activity;GO:0035731|dinitrosyl-iron complex binding;GO:0042803|protein homodimerization activity;GO:0043295|glutathione binding;","K00799","GST, gst; glutathione S-transferase [EC:2.5.1.18]"]
["ENSRNOG00000029528",31,2.608193328,125,8.041304773,0.324349518,-1.6243788,{"v":2.79382e-10,"d":"2.79E-10"},{"v":4.49345e-10,"d":"4.49E-10"},"down","yes","Cbs","protein_coding","chr20:9708090-9732764:-","gi|543960|sp|P32232.3|CBS_RAT",2948,0,"RecName: Full=Cystathionine beta-synthase; AltName: Full=Beta-thionase; AltName: Full=Hemoprotein H-450; AltName: Full=Serine sulfhydrase","gi|1364273|gb|M88344.1|RATRCBSA",2504,0,"Rat cystathionine beta-synthase (CBS) mRNA, complete cds (type 1 of four alternatively spliced mRNAs)","P32232",1140,0,"Cystathionine beta-synthase","YGR155w_1",338,{"v":1e-106,"d":"1.00E-106"},"COG0031","pfam00291","PALP","Pyridoxal-phosphate dependent enzyme. Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.","GO:0001958|endochondral ossification;GO:0001974|blood vessel remodeling;GO:0006535|cysteine biosynthetic process from serine;GO:0006563|L-serine metabolic process;GO:0006565|L-serine catabolic process;GO:0006801|superoxide metabolic process;GO:0010749|regulation of nitric oxide mediated signal transduction;GO:0019343|cysteine biosynthetic process via cystathionine;GO:0019344|cysteine biosynthetic process;GO:0019346|transsulfuration;GO:0019448|L-cysteine catabolic process;GO:0021587|cerebellum morphogenesis;GO:0031667|response to nutrient levels;GO:0042262|DNA protection;GO:0043066|negative regulation of apoptotic process;GO:0043418|homocysteine catabolic process;GO:0043506|regulation of JUN kinase activity;GO:0050667|homocysteine metabolic process;GO:0051593|response to folic acid;GO:0060135|maternal process involved in female pregnancy;GO:0060351|cartilage development involved in endochondral bone morphogenesis;GO:0070814|hydrogen sulfide biosynthetic process;GO:0071456|cellular response to hypoxia;GO:0097746|regulation of blood vessel diameter;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004122|cystathionine beta-synthase activity;GO:0019825|oxygen binding;GO:0019899|enzyme binding;GO:0020037|heme binding;GO:0030170|pyridoxal phosphate binding;GO:0031625|ubiquitin protein ligase binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0046872|metal ion binding;GO:0050421|nitrite reductase (NO-forming) activity;GO:0070025|carbon monoxide binding;GO:0070026|nitric oxide binding;GO:0072341|modified amino acid binding;GO:1904047|S-adenosyl-L-methionine binding;","K01697","CBS; cystathionine beta-synthase [EC:4.2.1.22]"]
["ENSRNOG00000005573",41,3.449546015,146,9.392243975,0.367276023,-1.44506338,{"v":3.90067E-10,"d":"3.90E-10"},{"v":6.19922e-10,"d":"6.20E-10"},"down","yes","Ntn4","protein_coding","chr7:28186611-28300390:+","gi|157817109|ref|NP_001100250.1|",3393,0,"netrin-4 precursor [Rattus norvegicus]","gi|157817108|ref|NM_001106780.1|",2092,0,"Rattus norvegicus netrin 4 (Ntn4), mRNA","Q9JI33",1279,0,"Netrin-4",".",".",".",".","pfam00055","Laminin_N","Laminin N-terminal (Domain VI).","GO:0009887|animal organ morphogenesis;GO:0009888|tissue development;GO:0016322|neuron remodeling;GO:0016477|cell migration;GO:0034446|substrate adhesion-dependent cell spreading;GO:0060668|regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling;GO:0070831|basement membrane assembly;","GO:0005576|extracellular region;GO:0005604|basement membrane;GO:0043256|laminin complex;","GO:0043237|laminin-1 binding;","K06845","NTN4; netrin 4"]
["ENSRNOG00000003765",56,4.711575044,177,11.38648756,0.413786518,-1.273041453,{"v":4.00571E-10,"d":"4.01E-10"},{"v":6.36244E-10,"d":"6.36E-10"},"down","yes","Nr0b1","protein_coding","chrX:50756886-50761011:+","gi|149042339|gb|EDL96046.1|",2515,0,"nuclear receptor subfamily 0, group B, member 1 [Rattus norvegicus]","gi|16758011|ref|NM_053317.1|",1725,0,"Rattus norvegicus nuclear receptor subfamily 0, group B, member 1 (Nr0b1), mRNA","P70503",953,0,"Nuclear receptor subfamily 0 group B member 1",".",".",".",".","pfam14046","NR_Repeat","Nuclear receptor repeat. This is a repeat domain involved in dimerization of nuclear receptors proteins and in transcriptional regulation in general. It contains a Leu-Xaa-Xaa-Leu-Leu motif which has been characterized for the orphan nuclear receptor Dax-1, which represses the constitutively expressed protein Ad4BP/SF-1. The LXXLL motif plays in important role in binding of Dax-1 to Ad4BP/SF-1. The domain is subject to structure determination by the Joint Center of Structural Genomics.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0007283|spermatogenesis;GO:0007530|sex determination;GO:0008104|protein localization;GO:0008406|gonad development;GO:0008584|male gonad development;GO:0010033|response to organic substance;GO:0010894|negative regulation of steroid biosynthetic process;GO:0030154|cell differentiation;GO:0030238|male sex determination;GO:0030325|adrenal gland development;GO:0033144|negative regulation of intracellular steroid hormone receptor signaling pathway;GO:0033327|Leydig cell differentiation;GO:0035902|response to immobilization stress;GO:0043433|negative regulation of DNA-binding transcription factor activity;GO:0043434|response to peptide hormone;GO:0045892|negative regulation of transcription, DNA-templated;GO:0050810|regulation of steroid biosynthetic process;GO:0060008|Sertoli cell differentiation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0016020|membrane;GO:0016607|nuclear speck;GO:0034451|centriolar satellite;GO:0042788|polysomal ribosome;GO:0043231|intracellular membrane-bounded organelle;","GO:0003677|DNA binding;GO:0003690|double-stranded DNA binding;GO:0003714|transcription corepressor activity;GO:0003723|RNA binding;GO:0008134|transcription factor binding;GO:0016922|nuclear receptor binding;GO:0019904|protein domain specific binding;GO:0032448|DNA hairpin binding;GO:0042803|protein homodimerization activity;GO:0043565|sequence-specific DNA binding;GO:0050682|AF-2 domain binding;","K08562","NR0B1, DAX1; nuclear receptor subfamily 0 group B member 1"]
["ENSRNOG00000008480",78,6.562550954,220,14.1526964,0.463696159,-1.10874832,{"v":4.16383e-10,"d":"4.16E-10"},{"v":6.60589e-10,"d":"6.61E-10"},"down","yes","Kcnab3","protein_coding","chr10:54047825-54054174:+","gi|13928902|ref|NP_113840.1|",1832,0,"voltage-gated potassium channel subunit beta-3 [Rattus norvegicus]","gi|672068038|ref|XM_008767862.1|",2105,0,"PREDICTED: Rattus norvegicus potassium voltage-gated channel, shaker-related subfamily, beta member 3 (Kcnab3), transcript variant X1, mRNA","Q63494",710,0,"Voltage-gated potassium channel subunit beta-3","TM0313",278,{"v":8e-86,"d":"8.00E-86"},"COG0667","pfam00248","Aldo_ket_red","Aldo/keto reductase family. This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.","GO:0071805|potassium ion transmembrane transport;GO:1901379|regulation of potassium ion transmembrane transport;","GO:0005737|cytoplasm;GO:0008076|voltage-gated potassium channel complex;","GO:0004033|aldo-keto reductase (NADP) activity;GO:0005249|voltage-gated potassium channel activity;GO:0015459|potassium channel regulator activity;GO:0044325|ion channel binding;GO:0047834|D-threo-aldose 1-dehydrogenase activity;","K04884","KCNAB3; potassium voltage-gated channel Shaker-related subfamily A, beta member 3"]
["ENSRNOG00000014231",5,0.420676343,56,3.602504538,0.1167733,-3.098217652,{"v":4.38496E-10,"d":"4.38E-10"},{"v":6.94333e-10,"d":"6.94E-10"},"down","yes","Pnoc","protein_coding","chr15:39624641-39651867:-","gi|6981378|ref|NP_037139.1|",765,{"v":3E-98,"d":"3.00E-98"},"prepronociceptin precursor [Rattus norvegicus]","gi|672078247|ref|XM_006252199.2|",1015,0,"PREDICTED: Rattus norvegicus prepronociceptin (Pnoc), transcript variant X2, mRNA","Q62923",299,{"v":9e-100,"d":"9.00E-100"},"Prepronociceptin",".",".",".",".","pfam01160","Opiods_neuropep","Vertebrate endogenous opioids neuropeptide.","GO:0007218|neuropeptide signaling pathway;GO:0007268|chemical synaptic transmission;GO:0007565|female pregnancy;GO:0007600|sensory perception;","GO:0005576|extracellular region;GO:0005886|plasma membrane;GO:0030425|dendrite;GO:0043025|neuronal cell body;GO:0043679|axon terminus;","GO:0001515|opioid peptide activity;GO:0031628|opioid receptor binding;","K25696","PNOC; prepronociceptin"]
["ENSRNOG00000013257",33,2.776463865,128,8.234296088,0.337182904,-1.568396706,{"v":4.81183e-10,"d":"4.81E-10"},{"v":7.59411e-10,"d":"7.59E-10"},"down","yes","Hecw2","protein_coding","chr9:55365203-55580327:-","gi|157817476|ref|NP_001101688.1|",8253,0,"E3 ubiquitin-protein ligase HECW2 [Rattus norvegicus]","gi|157817475|ref|NM_001108218.1|",5296,0,"Rattus norvegicus HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 (Hecw2), mRNA","Q6I6G8",3086,0,"E3 ubiquitin-protein ligase HECW2","YER125w",409,{"v":3E-122,"d":"3.00E-122"},"COG5021","pfam00632","HECT","HECT-domain (ubiquitin-transferase). The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.","GO:0000209|protein polyubiquitination;GO:0016567|protein ubiquitination;GO:0030071|regulation of mitotic metaphase/anaphase transition;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045732|positive regulation of protein catabolic process;GO:0048814|regulation of dendrite morphogenesis;GO:2000650|negative regulation of sodium ion transmembrane transporter activity;","GO:0005737|cytoplasm;GO:0072686|mitotic spindle;","GO:0016874|ligase activity;GO:0061630|ubiquitin protein ligase activity;","K12168","HECW2; E3 ubiquitin-protein ligase HECW2 [EC:2.3.2.26]"]
["ENSRNOG00000006921",68,5.721198268,200,12.86608764,0.444672726,-1.169184174,{"v":5.09133E-10,"d":"5.09E-10"},{"v":8.02359E-10,"d":"8.02E-10"},"down","yes","Rbl1","protein_coding","chr3:145807095-145869330:-","gi|300797136|ref|NP_001177995.1|",5422,0,"retinoblastoma-like protein 1 [Rattus norvegicus]","gi|300797135|ref|NM_001191066.1|",3022,0,"Rattus norvegicus retinoblastoma-like 1 (p107) (Rbl1), mRNA","Q64701",2049,0,"Retinoblastoma-like protein 1",".",".",".",".","pfam01858","RB_A","Retinoblastoma-associated protein A domain. This domain has the cyclin fold as predicted.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006325|chromatin organization;GO:0006357|regulation of transcription by RNA polymerase II;GO:0010629|negative regulation of gene expression;GO:0030154|cell differentiation;GO:0043550|regulation of lipid kinase activity;GO:0051302|regulation of cell division;GO:0051726|regulation of cell cycle;GO:2000134|negative regulation of G1/S transition of mitotic cell cycle;GO:2000773|negative regulation of cellular senescence;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:1990841|promoter-specific chromatin binding;","K04681","RBL1; retinoblastoma-like protein 1"]
["ENSRNOG00000000500",47,3.954357626,157,10.0998788,0.391525256,-1.352822722,{"v":6.69746e-10,"d":"6.70E-10"},{"v":1.04789E-9,"d":"1.05E-09"},"down","yes","Scube3","protein_coding","chr20:6199182-6228584:+","gi|405113053|ref|NP_001258291.1|",5274,0,"signal peptide, CUB and EGF-like domain-containing protein 3 precursor [Rattus norvegicus]","gi|672085944|ref|XM_008772805.1|",3950,0,"PREDICTED: Rattus norvegicus signal peptide, CUB domain, EGF-like 3 (Scube3), transcript variant X4, mRNA","Q66PY1",1971,0,"Signal peptide, CUB and EGF-like domain-containing protein 3",".",".",".",".","pfam00431","CUB","CUB domain.","GO:0007165|signal transduction;GO:0045880|positive regulation of smoothened signaling pathway;","GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0009986|cell surface;","GO:0005509|calcium ion binding;GO:0042802|identical protein binding;","K24468","SCUBE1_3; signal peptide, CUB and EGF-like domain-containing protein 1/3"]
["ENSRNOG00000009855",23,1.935111179,104,6.690365571,0.289238482,-1.789668587,{"v":7.18197e-10,"d":"7.18E-10"},{"v":1.12176e-09,"d":"1.12E-09"},"down","yes","Serpina5","protein_coding","chr6:123023306-123028407:+","gi|347921897|ref|NP_075246.3|",1866,0,"plasma serine protease inhibitor isoform 2 precursor [Rattus norvegicus]","gi|347921896|ref|NM_022957.3|",2158,0,"Rattus norvegicus serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 (Serpina5), transcript variant 2, mRNA","P70458",610,0,"Plasma serine protease inhibitor","all0778",135,{"v":1e-33,"d":"1.00E-33"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0007283|spermatogenesis;GO:0010951|negative regulation of endopeptidase activity;GO:0045861|negative regulation of proteolysis;GO:0051346|negative regulation of hydrolase activity;GO:0061107|seminal vesicle development;","GO:0002080|acrosomal membrane;GO:0005615|extracellular space;GO:0009897|external side of plasma membrane;GO:0016020|membrane;GO:0031091|platelet alpha granule;GO:0031094|platelet dense tubular network;GO:0032991|protein-containing complex;GO:0036024|protein C inhibitor-TMPRSS7 complex;GO:0036025|protein C inhibitor-TMPRSS11E complex;GO:0036026|protein C inhibitor-PLAT complex;GO:0036027|protein C inhibitor-PLAU complex;GO:0036028|protein C inhibitor-thrombin complex;GO:0036029|protein C inhibitor-KLK3 complex;GO:0036030|protein C inhibitor-plasma kallikrein complex;GO:0070062|extracellular exosome;GO:0097181|protein C inhibitor-coagulation factor V complex;GO:0097182|protein C inhibitor-coagulation factor Xa complex;GO:0097183|protein C inhibitor-coagulation factor XI complex;","GO:0001972|retinoic acid binding;GO:0002020|protease binding;GO:0004867|serine-type endopeptidase inhibitor activity;GO:0031210|phosphatidylcholine binding;GO:0032190|acrosin binding;","K03913","SERPINA5, PCI; protein C inhibitor"]
["ENSRNOG00000025781",52,4.37503397,167,10.74318318,0.407238143,-1.2960554,{"v":7.2848e-10,"d":"7.28E-10"},{"v":1.13685e-09,"d":"1.14E-09"},"down","yes","Sec31b","protein_coding","chr1:243378456-243404557:-","gi|564333979|ref|XP_006231546.1|",5520,0,"PREDICTED: protein transport protein Sec31B isoform X1 [Rattus norvegicus]","gi|672040430|ref|XM_006231484.2|",4103,0,"PREDICTED: Rattus norvegicus SEC31 homolog B (S. cerevisiae) (Sec31b), transcript variant X1, mRNA","Q3TZ89",1857,0,"Protein transport protein Sec31B",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.","GO:0006886|intracellular protein transport;GO:0007029|endoplasmic reticulum organization;GO:0090110|cargo loading into COPII-coated vesicle;","GO:0005789|endoplasmic reticulum membrane;GO:0030120|vesicle coat;GO:0030127|COPII vesicle coat;GO:0070971|endoplasmic reticulum exit site;","GO:0005198|structural molecule activity;","K14005","SEC31; protein transport protein SEC31"]
["ENSRNOG00000029956",47,3.954357626,156,10.03554836,0.394035033,-1.343604192,{"v":9.28597e-10,"d":"9.29E-10"},{"v":1.43924e-09,"d":"1.44E-09"},"down","yes","Zfp654","protein_coding","chr11:2503508-2565637:-","gi|672025776|ref|XP_008774179.1|",5312,0,"PREDICTED: zinc finger protein 654 isoform X1 [Rattus norvegicus]","gi|672025777|ref|XM_001063334.5|",3370,0,"PREDICTED: Rattus norvegicus zinc finger protein 654 (Zfp654), transcript variant X2, mRNA","Q9DAU9",1091,0,"Zinc finger protein 654",".",".",".",".","pfam09726","Macoilin","Transmembrane protein. This entry is a highly conserved protein present in eukaryotes.",".",".",".",".","."]
["ENSRNOG00000012620",4,0.336541075,51,3.280852347,0.10257733,-3.285216167,{"v":9.79721e-10,"d":"9.80E-10"},{"v":1.51632E-9,"d":"1.52E-09"},"down","yes","Syngr3","protein_coding","chr10:13704998-13715669:-","gi|831227424|ref|XP_003790837.2|",961,{"v":1e-120,"d":"1.00E-120"},"PREDICTED: synaptogyrin-3 [Otolemur garnettii]","gi|672066853|ref|XM_006245947.2|",1993,0,"PREDICTED: Rattus norvegicus synaptogyrin 3 (Syngr3), transcript variant X1, mRNA","Q8R191",367,{"v":1E-119,"d":"1.00E-119"},"Synaptogyrin-3",".",".",".",".","pfam01284","MARVEL","Membrane-associating domain. MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.","GO:0001504|neurotransmitter uptake;GO:0021762|substantia nigra development;GO:0032411|positive regulation of transporter activity;GO:0045055|regulated exocytosis;","GO:0008021|synaptic vesicle;GO:0016021|integral component of membrane;GO:0030672|synaptic vesicle membrane;GO:0031594|neuromuscular junction;GO:0045202|synapse;","GO:0042169|SH2 domain binding;GO:0047485|protein N-terminus binding;",".","."]
["ENSRNOG00000062859",0,0.042067634,39,2.508887089,0.016767448,-5.898193044,{"v":1.04608E-9,"d":"1.05E-09"},{"v":1.61489E-9,"d":"1.61E-09"},"down","yes","RGD1565622","protein_coding","chr5:158198851-158228089:-","gi|672020249|ref|XP_008774368.1|",3671,0,"PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 260-like isoform X1, partial [Rattus norvegicus]","gi|672020248|ref|XM_008776146.1|",2205,0,"PREDICTED: Rattus norvegicus RGD1565622 (RGD1565622), transcript variant X1, partial mRNA","Q8TAQ5",550,0,"Zinc finger protein 420",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000003494",72,6.057739343,205,13.18773983,0.459346288,-1.122345923,{"v":1.12488e-09,"d":"1.12E-09"},{"v":1.73058E-9,"d":"1.73E-09"},"down","yes","Ppfia4","protein_coding","chr13:45753827-45802261:-","gi|672073998|ref|XP_008767751.1|",5691,0,"PREDICTED: liprin-alpha-4 isoform X1 [Rattus norvegicus]","gi|281306778|ref|NM_080409.1|",5828,0,"Rattus norvegicus PTPRF interacting protein alpha 4 (Ppfia4), mRNA","O75335",1914,0,"Liprin-alpha-4",".",".",".",".","pfam12128","DUF3584","Protein of unknown function (DUF3584). This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.","GO:0050808|synapse organization;","GO:0005737|cytoplasm;GO:0009986|cell surface;GO:0045202|synapse;GO:0048786|presynaptic active zone;","GO:0005515|protein binding;",".","."]
["ENSRNOG00000020035",37,3.11300494,134,8.620278717,0.361125787,-1.46942665,{"v":1.2739e-09,"d":"1.27E-09"},{"v":1.95e-09,"d":"1.95E-09"},"down","yes","Cyp17a1","protein_coding","chr1:245535462-245541573:-","gi|564333876|ref|XP_006231496.1|",2594,0,"PREDICTED: steroid 17-alpha-hydroxylase/17,20 lyase isoform X1 [Rattus norvegicus]","gi|672040337|ref|XM_006231435.2|",1830,0,"PREDICTED: Rattus norvegicus cytochrome P450, family 17, subfamily a, polypeptide 1 (Cyp17a1), transcript variant X2, mRNA","P11715",983,0,"Steroid 17-alpha-hydroxylase/17,20 lyase","BH0579",116,{"v":6e-27,"d":"6.00E-27"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0006082|organic acid metabolic process;GO:0006694|steroid biosynthetic process;GO:0006702|androgen biosynthetic process;GO:0006704|glucocorticoid biosynthetic process;GO:0008202|steroid metabolic process;GO:0008584|male gonad development;GO:0009410|response to xenobiotic stimulus;GO:0009635|response to herbicide;GO:0009636|response to toxic substance;GO:0010033|response to organic substance;GO:0010034|response to acetate;GO:0010212|response to ionizing radiation;GO:0014070|response to organic cyclic compound;GO:0017085|response to insecticide;GO:0018879|biphenyl metabolic process;GO:0018894|dibenzo-p-dioxin metabolic process;GO:0018958|phenol-containing compound metabolic process;GO:0018963|phthalate metabolic process;GO:0021766|hippocampus development;GO:0030325|adrenal gland development;GO:0030728|ovulation;GO:0031667|response to nutrient levels;GO:0032526|response to retinoic acid;GO:0033327|Leydig cell differentiation;GO:0034097|response to cytokine;GO:0034698|response to gonadotropin;GO:0042446|hormone biosynthetic process;GO:0042448|progesterone metabolic process;GO:0048545|response to steroid hormone;GO:0051591|response to cAMP;GO:0051597|response to methylmercury;GO:0060992|response to fungicide;GO:0071222|cellular response to lipopolysaccharide;GO:0071236|cellular response to antibiotic;GO:0071371|cellular response to gonadotropin stimulus;GO:0090031|positive regulation of steroid hormone biosynthetic process;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016020|membrane;GO:0030424|axon;GO:0042995|cell projection;GO:0043025|neuronal cell body;GO:0043231|intracellular membrane-bounded organelle;","GO:0004508|steroid 17-alpha-monooxygenase activity;GO:0005506|iron ion binding;GO:0020037|heme binding;GO:0047442|17-alpha-hydroxyprogesterone aldolase activity;","K00512","CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase [EC:1.14.14.19 1.14.14.32]"]
["ENSRNOG00000005007",49,4.122628164,159,10.22853967,0.403051491,-1.310963936,{"v":1.32879e-09,"d":"1.33E-09"},{"v":2.03061e-09,"d":"2.03E-09"},"down","yes","Scn3a","protein_coding","chr3:50148139-50258119:-","gi|354478609|ref|XP_003501507.1|",8956,0,"PREDICTED: sodium channel protein type 3 subunit alpha isoform X2 [Cricetulus griseus]","gi|672045851|ref|XM_008761918.1|",4527,0,"PREDICTED: Rattus norvegicus sodium channel, voltage-gated, type III, alpha (Scn3a), transcript variant X5, mRNA","Q9NY46",3390,0,"Sodium channel protein type 3 subunit alpha",".",".",".",".","pfam06512","Na_trans_assoc","Sodium ion transport-associated. Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.","GO:0007399|nervous system development;GO:0009611|response to wounding;GO:0019228|neuronal action potential;GO:0019233|sensory perception of pain;GO:0034765|regulation of ion transmembrane transport;GO:0035725|sodium ion transmembrane transport;GO:0046684|response to pyrethroid;GO:0071236|cellular response to antibiotic;GO:0086010|membrane depolarization during action potential;","GO:0001518|voltage-gated sodium channel complex;GO:0005737|cytoplasm;GO:0016020|membrane;GO:0030424|axon;GO:0043025|neuronal cell body;","GO:0005244|voltage-gated ion channel activity;GO:0005248|voltage-gated sodium channel activity;GO:0005515|protein binding;GO:0005516|calmodulin binding;GO:0031402|sodium ion binding;","K04836","SCN3A, NAV1.3; voltage-gated sodium channel type III alpha"]
["ENSRNOG00000003187",91,7.656309447,240,15.43930516,0.495897281,-1.011886781,{"v":1.39289e-09,"d":"1.39E-09"},{"v":2.12439e-09,"d":"2.12E-09"},"down","yes","ENSRNOG00000003187","protein_coding","chrX:98709841-98714674:+","gi|564323153|ref|XP_006227542.1|",2457,0,"PREDICTED: armadillo repeat-containing X-linked protein 5 [Rattus norvegicus]","gi|672032625|ref|XM_006227480.2|",2282,0,"PREDICTED: Rattus norvegicus armadillo repeat-containing X-linked protein 5-like (LOC102552920), mRNA",".",".",".",".",".",".",".",".","pfam04826","Arm_2","Armadillo-like. This domain contains armadillo-like repeats. Proteins containing this domain interact with numerous other proteins, through these interactions they are involved in a wide variety of processes including carcinogenesis, control of cellular ageing and survival, regulation of circadian rhythm and lysosomal sorting of G protein-coupled receptors.",".",".",".",".","."]
["ENSRNOG00000054360",72,6.057739343,204,13.12340939,0.461597986,-1.115291166,{"v":1.49482E-9,"d":"1.49E-09"},{"v":2.27666e-09,"d":"2.28E-09"},"down","yes","Tspan11","protein_coding","chr4:160738404-160805520:+","gi|66730384|ref|NP_001019433.1|",1334,{"v":3E-171,"d":"3.00E-171"},"tetraspanin-11 [Rattus norvegicus]","gi|66730383|ref|NM_001024262.1|",3783,0,"Rattus norvegicus tetraspanin 11 (Tspan11), mRNA","Q568Y5",518,{"v":1E-172,"d":"1.00E-172"},"Tetraspanin-11",".",".",".",".","pfam00335","Tetraspannin","Tetraspanin family.","GO:0016477|cell migration;","GO:0005887|integral component of plasma membrane;",".","K17352","TSPAN11; tetraspanin-11"]
["ENSRNOG00000006575",12,1.009623224,74,4.760452426,0.212085561,-2.23728169,{"v":1.82229e-09,"d":"1.82E-09"},{"v":2.75231E-9,"d":"2.75E-09"},"down","yes","Ccdc96","protein_coding","chr14:74276960-74278888:-","gi|109499890|ref|XP_223518.4|",2172,0,"PREDICTED: coiled-coil domain-containing protein 96 [Rattus norvegicus]","gi|672028047|ref|XM_001063560.4|",1711,0,"PREDICTED: Rattus norvegicus coiled-coil domain containing 96 (Ccdc96), mRNA","Q9CR92",693,0,"Coiled-coil domain-containing protein 96",".",".",".",".","pfam13870","DUF4201","Domain of unknown function (DUF4201). This is a family of coiled-coil proteins from eukaryotes. The function is not known.","GO:0060271|cilium assembly;","GO:0005930|axoneme;GO:0036064|ciliary basal body;",".",".","."]
["ENSRNOG00000056819",87,7.319768372,231,14.86033122,0.492571011,-1.021596371,{"v":2.11673E-9,"d":"2.12E-09"},{"v":3.17588E-9,"d":"3.18E-09"},"down","yes","Susd1","protein_coding","chr5:74157773-74276291:-","gi|261598994|ref|NP_001156760.2|",3332,0,"sushi domain-containing protein 1 precursor [Mus musculus]","gi|672019394|ref|XM_008775964.1|",2071,0,"PREDICTED: Rattus norvegicus sushi domain containing 1 (Susd1), transcript variant X3, mRNA","Q6UWL2",1033,0,"Sushi domain-containing protein 1",".",".",".",".","pfam12947","EGF_3","EGF domain. This family includes a variety of EGF-like domain homologues. This family includes the C-terminal domain of the malaria parasite MSP1 protein.",".",".","GO:0005509|calcium ion binding;","K23819","SUSD1; sushi domain-containing protein 1"]
["ENSRNOG00000005451",43,3.617816552,145,9.327913537,0.387848423,-1.366435161,{"v":2.25829e-09,"d":"2.26E-09"},{"v":3.37896e-09,"d":"3.38E-09"},"down","yes","Dnah11","protein_coding","chr6:138839177-139155536:-","gi|293348432|ref|XP_001061747.2|",23121,0,"PREDICTED: dynein heavy chain 11, axonemal isoform X1 [Rattus norvegicus]","gi|672021264|ref|XM_008776347.1|",9404,0,"PREDICTED: Rattus norvegicus dynein, axonemal, heavy chain 11 (Dnah11), transcript variant X6, mRNA","Q96DT5",7579,0,"Dynein heavy chain 11, axonemal","YKR054c",671,0,"COG5245","pfam03028","Dynein_heavy","Dynein heavy chain and region D6 of dynein motor. This family represents the C-terminal region of dynein heavy chain. The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained.","GO:0003341|cilium movement;GO:0003351|epithelial cilium movement;GO:0003356|regulation of cilium beat frequency;GO:0007018|microtubule-based movement;GO:0007368|determination of left/right symmetry;GO:0007507|heart development;GO:0007611|learning or memory;GO:0008150|biological_process;GO:0030317|flagellated sperm motility;GO:0035545|determination of left/right asymmetry in nervous system;GO:0060287|epithelial cilium movement involved in determination of left/right asymmetry;GO:0060411|cardiac septum morphogenesis;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005874|microtubule;GO:0005929|cilium;GO:0005930|axoneme;GO:0030286|dynein complex;GO:0031514|motile cilium;GO:0097728|9+0 motile cilium;GO:0097729|9+2 motile cilium;GO:0120134|proximal portion of axoneme;","GO:0003674|molecular_function;GO:0005524|ATP binding;GO:0008569|ATP-dependent microtubule motor activity, minus-end-directed;GO:0045505|dynein intermediate chain binding;GO:0051959|dynein light intermediate chain binding;","K10408","DNAH; dynein axonemal heavy chain"]
["ENSRNOG00000005291",35,2.944734403,128,8.234296088,0.357618231,-1.483507808,{"v":2.29462e-09,"d":"2.29E-09"},{"v":3.43049e-09,"d":"3.43E-09"},"down","yes","Slc38a1","protein_coding","chr7:127738226-127802218:-","gi|20301960|ref|NP_620187.1|",2287,0,"sodium-coupled neutral amino acid transporter 1 [Rattus norvegicus]","gi|20301959|ref|NM_138832.1|",2110,0,"Rattus norvegicus solute carrier family 38, member 1 (Slc38a1), mRNA","Q9JM15",885,0,"Sodium-coupled neutral amino acid transporter 1","YEL064c",94,{"v":2E-19,"d":"2.00E-19"},"COG0814","pfam01490","Aa_trans","Transmembrane amino acid transporter protein. This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.","GO:0003333|amino acid transmembrane transport;GO:0006814|sodium ion transport;GO:0006868|glutamine transport;GO:0007565|female pregnancy;GO:0015804|neutral amino acid transport;GO:0015807|L-amino acid transport;GO:1902475|L-alpha-amino acid transmembrane transport;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0016323|basolateral plasma membrane;GO:0030424|axon;GO:0043025|neuronal cell body;GO:0098591|external side of apical plasma membrane;","GO:0005295|neutral amino acid:sodium symporter activity;GO:0015171|amino acid transmembrane transporter activity;GO:0015179|L-amino acid transmembrane transporter activity;GO:0015186|L-glutamine transmembrane transporter activity;","K14990","SLC38A1, SNAT1, GLNT; solute carrier family 38 (sodium-coupled neutral amino acid transporter), member 1"]
["ENSRNOG00000053026",63,5.300521925,185,11.90113106,0.445379678,-1.166892362,{"v":2.38332E-9,"d":"2.38E-09"},{"v":3.55822e-09,"d":"3.56E-09"},"down","yes","Shcbp1","protein_coding","chr16:84672321-84703844:+","gi|6755508|ref|NP_035499.1|",3190,0,"SHC SH2 domain-binding protein 1 [Mus musculus]","gi|672029630|ref|XM_008773569.1|",2775,0,"PREDICTED: Rattus norvegicus Shc SH2-domain binding protein 1 (Shcbp1), transcript variant X1, mRNA","Q9Z179",1233,0,"SHC SH2 domain-binding protein 1",".",".",".",".","pfam13229","Beta_helix","Right handed beta helix region. This region contains a parallel beta helix region that shares some similarity with Pectate lyases.","GO:0008543|fibroblast growth factor receptor signaling pathway;GO:2000177|regulation of neural precursor cell proliferation;",".","GO:0042169|SH2 domain binding;",".","."]
["ENSRNOG00000017491",56,4.711575044,171,11.00050493,0.428305344,-1.223288418,{"v":2.55647E-9,"d":"2.56E-09"},{"v":3.80212e-09,"d":"3.80E-09"},"down","yes","Carf","protein_coding","chr9:61506956-61550462:+","gi|564368492|ref|XP_006245036.1|",3224,0,"PREDICTED: calcium-responsive transcription factor isoform X3 [Rattus norvegicus]","gi|672065117|ref|XM_006244970.2|",3408,0,"PREDICTED: Rattus norvegicus calcium responsive transcription factor (Carf), transcript variant X2, mRNA","Q8VHI4",1062,0,"Calcium-responsive transcription factor",".",".",".",".","pfam15299","ALS2CR8","Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8. This domain is found in amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0035865|cellular response to potassium ion;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051090|regulation of DNA-binding transcription factor activity;GO:0061400|positive regulation of transcription from RNA polymerase II promoter in response to calcium ion;GO:0071277|cellular response to calcium ion;","GO:0001652|granular component;GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;","K21595","CARF; calcium-responsive transcription factor"]
["ENSRNOG00000009116",81,6.81495676,219,14.08836596,0.483729396,-1.047727882,{"v":2.63119e-09,"d":"2.63E-09"},{"v":3.91005e-09,"d":"3.91E-09"},"down","yes","Itgb3bp","protein_coding","chr5:114460221-114525704:-","gi|61557307|ref|NP_001013231.1|",901,{"v":2e-117,"d":"2.00E-117"},"centromere protein R [Rattus norvegicus]","gi|61557306|ref|NM_001013213.1|",705,0,"Rattus norvegicus integrin subunit beta 3 binding protein (Itgb3bp), mRNA","Q5U1Z7",351,{"v":7e-119,"d":"7.00E-119"},"Centromere protein R",".",".",".",".","pfam06729","CENP-R","Kinetochore component, CENP-R. This family consists of mammalian kinetochore sub-complex proteins CENP-R, also referred to as nuclear receptor co-activator NRIF3 proteins. NRIF3 exhibits a distinct receptor specificity in interacting with and potentiating the activity of only TRs and RXRs but not other examined nuclear receptors. NRIF3 as a co-regulator that possesses both transactivation and transrepression domains and/or functions. Collectively, the NRIF3 family of co-regulators may play dual roles in mediating both positive and negative regulatory effects on gene expression. CENP-R is one of the 15 components that make up the constitutive centromere associated complex (CCAN) part of the kinetochore. A sub-complex of CCAN, consisting of CENP-P/O/R/Q/U self-assembles on kinetochores with varying stoichiometry and undergoes a pre-mitotic maturation step. Kinetochore assembly is a cell cycle regulated multi-step process. The initial step occurs during interphase and involves loading of the 15-subunit constitutive centromere associated complex (CCAN). Kinetochores are multi-protein megadalton assemblies that are required for attachment of microtubules to centromeres and, in turn, the segregation of chromosomes in mitosis.","GO:0006355|regulation of transcription, DNA-templated;GO:0006915|apoptotic process;GO:0034080|CENP-A containing nucleosome assembly;GO:0051301|cell division;","GO:0000776|kinetochore;GO:0005634|nucleus;GO:0005654|nucleoplasm;",".","K11510","ITGB3BP, CENPR; centromere protein R"]
["ENSRNOG00000045741",38,3.197140209,134,8.620278717,0.370885944,-1.430952502,{"v":2.66099e-09,"d":"2.66E-09"},{"v":3.95002e-09,"d":"3.95E-09"},"down","yes","AABR07071891.2","protein_coding","chr1:61123043-61148954:+","gi|672012885|ref|XP_008772576.1|",221,{"v":4e-20,"d":"4.00E-20"},"PREDICTED: zinc finger protein 525-like isoform X2 [Rattus norvegicus]","gi|672034827|ref|XM_008758857.1|",117,{"v":5E-53,"d":"5.00E-53"},"PREDICTED: Rattus norvegicus zinc finger protein 679-like (LOC103691005), transcript variant X3, mRNA","Q95K52",75.9,{"v":6e-16,"d":"6.00E-16"},"Zinc finger protein 283",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000012315",40,3.365410746,138,8.87760047,0.379090133,-1.399387187,{"v":2.87474e-09,"d":"2.87E-09"},{"v":4.25803e-09,"d":"4.26E-09"},"down","yes","Agmat","protein_coding","chr5:154060151-154074276:+","gi|114687632|ref|NP_001041650.1|",1770,0,"agmatinase, mitochondrial precursor [Rattus norvegicus]","gi|114687631|ref|NM_001048185.1|",1270,0,"Rattus norvegicus agmatinase (Agmat), mRNA","Q0D2L3",686,0,"Agmatinase, mitochondrial","PA1421",380,{"v":6e-129,"d":"6.00E-129"},"COG0010","pfam00491","Arginase","Arginase family.","GO:0008295|spermidine biosynthetic process;GO:0033389|putrescine biosynthetic process from arginine, using agmatinase;","GO:0005739|mitochondrion;","GO:0008783|agmatinase activity;GO:0046872|metal ion binding;","K01480","speB; agmatinase [EC:3.5.3.11]"]
["ENSRNOG00000020701",81,6.81495676,218,14.02403552,0.485948338,-1.041125147,{"v":3.44579e-09,"d":"3.45E-09"},{"v":5.0735e-09,"d":"5.07E-09"},"down","yes","Brca1","protein_coding","chr10:86418000-86477304:-","gi|672068852|ref|XP_008766314.1|",9060,0,"PREDICTED: breast cancer type 1 susceptibility protein homolog isoform X1 [Rattus norvegicus]","gi|672068851|ref|XM_008768092.1|",5419,0,"PREDICTED: Rattus norvegicus breast cancer 1, early onset (Brca1), transcript variant X1, mRNA","O54952",3447,0,"Breast cancer type 1 susceptibility protein homolog",".",".",".",".","pfam04873","EIN3","Ethylene insensitive 3. Ethylene insensitive 3 (EIN3) proteins are a family of plant DNA-binding proteins that regulate transcription in response to the gaseous plant hormone ethylene, and are essential for ethylene-mediated responses including the triple response, cell growth inhibition, and accelerated senescence.","GO:0000724|double-strand break repair via homologous recombination;GO:0006301|postreplication repair;GO:0006302|double-strand break repair;GO:0006349|regulation of gene expression by genetic imprinting;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006633|fatty acid biosynthetic process;GO:0006974|cellular response to DNA damage stimulus;GO:0007059|chromosome segregation;GO:0007095|mitotic G2 DNA damage checkpoint;GO:0007098|centrosome cycle;GO:0007420|brain development;GO:0007584|response to nutrient;GO:0008630|intrinsic apoptotic signaling pathway in response to DNA damage;GO:0009048|dosage compensation by inactivation of X chromosome;GO:0010033|response to organic substance;GO:0010212|response to ionizing radiation;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0010628|positive regulation of gene expression;GO:0016567|protein ubiquitination;GO:0031398|positive regulation of protein ubiquitination;GO:0032355|response to estradiol;GO:0033147|negative regulation of intracellular estrogen receptor signaling pathway;GO:0033993|response to lipid;GO:0035066|positive regulation of histone acetylation;GO:0035067|negative regulation of histone acetylation;GO:0042307|positive regulation of protein import into nucleus;GO:0043009|chordate embryonic development;GO:0043627|response to estrogen;GO:0044030|regulation of DNA methylation;GO:0044818|mitotic G2/M transition checkpoint;GO:0045717|negative regulation of fatty acid biosynthetic process;GO:0045739|positive regulation of DNA repair;GO:0045766|positive regulation of angiogenesis;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051571|positive regulation of histone H3-K4 methylation;GO:0051572|negative regulation of histone H3-K4 methylation;GO:0051573|negative regulation of histone H3-K9 methylation;GO:0051574|positive regulation of histone H3-K9 methylation;GO:0051726|regulation of cell cycle;GO:0051865|protein autoubiquitination;GO:0070512|positive regulation of histone H4-K20 methylation;GO:0071356|cellular response to tumor necrosis factor;GO:0071681|cellular response to indole-3-methanol;GO:0085020|protein K6-linked ubiquitination;GO:1902042|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:2000378|negative regulation of reactive oxygen species metabolic process;GO:2000617|positive regulation of histone H3-K9 acetylation;GO:2000620|positive regulation of histone H4-K16 acetylation;","GO:0000793|condensed chromosome;GO:0000794|condensed nuclear chromosome;GO:0000800|lateral element;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005694|chromosome;GO:0005737|cytoplasm;GO:0005759|mitochondrial matrix;GO:0005886|plasma membrane;GO:0016604|nuclear body;GO:0031436|BRCA1-BARD1 complex;GO:0032991|protein-containing complex;GO:0070531|BRCA1-A complex;GO:1990904|ribonucleoprotein complex;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0003682|chromatin binding;GO:0003684|damaged DNA binding;GO:0003713|transcription coactivator activity;GO:0003723|RNA binding;GO:0004842|ubiquitin-protein transferase activity;GO:0005515|protein binding;GO:0008270|zinc ion binding;GO:0019899|enzyme binding;GO:0031625|ubiquitin protein ligase binding;GO:0070063|RNA polymerase binding;","K10605","BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]"]
["ENSRNOG00000023496",7,0.588946881,58,3.731165415,0.157845288,-2.663416898,{"v":3.9531e-09,"d":"3.95E-09"},{"v":5.78914e-09,"d":"5.79E-09"},"down","yes","Fam189a1","protein_coding","chr1:118288379-118700671:-","gi|166795260|ref|NP_898910.2|",2266,0,"protein FAM189A1 [Mus musculus]","gi|166795259|ref|NM_183087.4|",3018,0,"Mus musculus family with sequence similarity 189, member A1 (Fam189a1), mRNA","Q6A044",877,0,"Protein FAM189A1",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000010484",82,6.899092029,219,14.08836596,0.489701364,-1.03002588,{"v":4.34498e-09,"d":"4.34E-09"},{"v":6.35107e-09,"d":"6.35E-09"},"down","yes","Zdhhc21","protein_coding","chr5:97229345-97286537:-","gi|148699086|gb|EDL31033.1|",1344,{"v":4e-166,"d":"4.00E-166"},"zinc finger, DHHC domain containing 21 [Mus musculus]","gi|84781734|ref|NM_001039009.1|",3468,0,"Rattus norvegicus zinc finger, DHHC-type containing 21 (Zdhhc21), mRNA","Q9D270",509,{"v":1e-163,"d":"1.00E-163"},"Probable palmitoyltransferase ZDHHC21","SPBC2F12.15c",88.2,{"v":2e-17,"d":"2.00E-17"},"COG5273","pfam01529","zf-DHHC","DHHC palmitoyltransferase. This family includes the well known DHHC zinc binding domain as well as three of the four conserved transmembrane regions found in this family of palmitoyltransferase enzymes.","GO:0001942|hair follicle development;GO:0003056|regulation of vascular smooth muscle contraction;GO:0006612|protein targeting to membrane;GO:0018230|peptidyl-L-cysteine S-palmitoylation;GO:0018345|protein palmitoylation;GO:0048733|sebaceous gland development;GO:0071875|adrenergic receptor signaling pathway;GO:1903140|regulation of establishment of endothelial barrier;GO:1904997|regulation of leukocyte adhesion to arterial endothelial cell;","GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0016409|palmitoyltransferase activity;GO:0019706|protein-cysteine S-palmitoyltransferase activity;","K18932","ZDHHC; palmitoyltransferase [EC:2.3.1.225]"]
["ENSRNOG00000014081",1,0.084135269,37,2.380226213,0.035347594,-4.822244191,{"v":4.75746e-09,"d":"4.76E-09"},{"v":6.92425e-09,"d":"6.92E-09"},"down","yes","Nmur2","protein_coding","chr10:40166226-40182078:-","gi|149052674|gb|EDM04491.1|",2161,0,"neuromedin U receptor 2 [Rattus norvegicus]","gi|399154158|ref|NM_022275.3|",3302,0,"Rattus norvegicus neuromedin U receptor 2 (Nmur2), mRNA","Q9ESQ4",752,0,"Neuromedin-U receptor 2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0002023|reduction of food intake in response to dietary excess;GO:0006816|calcium ion transport;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007218|neuropeptide signaling pathway;GO:0007417|central nervous system development;GO:0007625|grooming behavior;GO:0015698|inorganic anion transport;GO:0043006|activation of phospholipase A2 activity by calcium-mediated signaling;GO:0048016|inositol phosphate-mediated signaling;GO:0048265|response to pain;GO:0050482|arachidonic acid secretion;GO:0051930|regulation of sensory perception of pain;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0001607|neuromedin U receptor activity;GO:0004930|G protein-coupled receptor activity;GO:0005229|intracellular calcium activated chloride channel activity;GO:0005525|GTP binding;GO:0008188|neuropeptide receptor activity;GO:0042924|neuromedin U binding;","K05053","NMUR2; neuromedin U receptor 2"]
["ENSRNOG00000013148",33,2.776463865,121,7.78398302,0.356689353,-1.487259943,{"v":5.86139e-09,"d":"5.86E-09"},{"v":8.48561e-09,"d":"8.49E-09"},"down","yes","Rad54l","protein_coding","chr5:129575378-129605070:-","gi|201066350|ref|NP_001128432.1|",3906,0,"DNA repair and recombination protein RAD54-like [Rattus norvegicus]","gi|201066349|ref|NM_001134960.1|",2379,0,"Rattus norvegicus RAD54 like (S. cerevisiae) (Rad54l), mRNA","P70270",1475,0,"DNA repair and recombination protein RAD54-like","SPAC15A10.03c",650,0,"COG0553","pfam00176","SNF2_N","SNF2 family N-terminal domain. This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1).","GO:0000724|double-strand break repair via homologous recombination;GO:0006302|double-strand break repair;GO:0006974|cellular response to DNA damage stimulus;GO:0008150|biological_process;GO:0008340|determination of adult lifespan;GO:0009410|response to xenobiotic stimulus;GO:0010212|response to ionizing radiation;GO:0051276|chromosome organization;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0032991|protein-containing complex;","GO:0003674|molecular_function;GO:0005524|ATP binding;GO:0036310|annealing helicase activity;","K10875","RAD54L, RAD54; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]"]
["ENSRNOG00000068949",43,3.617816552,142,9.134922222,0.396042403,-1.33627319,{"v":6.04116e-09,"d":"6.04E-09"},{"v":8.73657e-09,"d":"8.74E-09"},"down","yes","ENSRNOG00000068949","protein_coding","chr3:144662361-144664459:+","gi|48927992|gb|AAT47707.1|",316,{"v":2e-31,"d":"2.00E-31"},"RNA-binding region containing protein 2 [Rattus norvegicus]","gi|49615115|gb|AC118414.9|",2099,0,"Rattus norvegicus 3 BAC CH230-223K21 (Children's Hospital Oakland Research Institute) complete sequence","Q14498",65.1,{"v":2e-17,"d":"2.00E-17"},"RNA-binding protein 39",".",".",".",".","pfam01105","EMP24_GP25L","emp24/gp25L/p24 family/GOLD. Members of this family are implicated in bringing cargo forward from the ER and binding to coat proteins by their cytoplasmic domains. This domain corresponds closely to the beta-strand rich GOLD domain described in. The GOLD domain is always found combined with lipid- or membrane-association domains.",".",".",".",".","."]
["ENSRNOG00000002970",80,6.730821492,214,13.76671377,0.488919985,-1.032329717,{"v":6.10886e-09,"d":"6.11E-09"},{"v":8.82979e-09,"d":"8.83E-09"},"down","yes","Zswim7","protein_coding","chr10:46957525-46969671:-","gi|254553360|ref|NP_001156964.1|",553,{"v":2e-67,"d":"2.00E-67"},"zinc finger SWIM domain-containing protein 7 [Rattus norvegicus]","gi|254553359|ref|NM_001163492.1|",588,0,"Rattus norvegicus zinc finger, SWIM-type containing 7 (Zswim7), mRNA","Q19AV6",197,{"v":3e-61,"d":"3.00E-61"},"Zinc finger SWIM domain-containing protein 7",".",".",".",".","pfam04434","SWIM","SWIM zinc finger. This domain is found in bacterial, archaeal and eukaryotic proteins. It is predicted to be organized into two N-terminal beta-strands and a C-terminal alpha helix, thus possibly adopting a fold similar to that of the C2H2 zinc finger (pfam00096). SWIM is thought to be a versatile domain that can interact with DNA or proteins in different contexts.","GO:0000724|double-strand break repair via homologous recombination;GO:0050821|protein stabilization;","GO:0097196|Shu complex;","GO:0008270|zinc ion binding;",".","."]
["ENSRNOG00000059997",45,3.786087089,146,9.392243975,0.40310783,-1.310762288,{"v":6.24712e-09,"d":"6.25E-09"},{"v":9.01765e-09,"d":"9.02E-09"},"down","yes","Brip1","protein_coding","chr10:70907371-71030324:-","gi|109488700|ref|XP_340870.3|",6064,0,"PREDICTED: Fanconi anemia group J protein [Rattus norvegicus]","gi|672025061|ref|XM_001081096.4|",3797,0,"PREDICTED: Rattus norvegicus BRCA1 interacting protein C-terminal helicase 1 (Brip1), transcript variant X1, mRNA","Q5SXJ3",2058,0,"Fanconi anemia group J protein homolog","ECU02g1090",335,{"v":4e-99,"d":"4.00E-99"},"COG1199","pfam06733","DEAD_2","DEAD_2. This represents a conserved region within a number of RAD3-like DNA-binding helicases that are seemingly ubiquitous - members include proteins of eukaryotic, bacterial and archaeal origin. RAD3 is involved in nucleotide excision repair, and forms part of the transcription factor TFIIH in yeast.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0007129|synapsis;GO:0007283|spermatogenesis;GO:0007284|spermatogonial cell division;GO:0007286|spermatid development;GO:0008285|negative regulation of cell proliferation;GO:0008584|male gonad development;GO:0009636|response to toxic substance;GO:0010629|negative regulation of gene expression;GO:0010705|meiotic DNA double-strand break processing involved in reciprocal meiotic recombination;GO:0032508|DNA duplex unwinding;GO:0051026|chiasma assembly;GO:0071295|cellular response to vitamin;GO:0071456|cellular response to hypoxia;GO:0072520|seminiferous tubule development;GO:1904385|cellular response to angiotensin;GO:1990918|double-strand break repair involved in meiotic recombination;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0031965|nuclear membrane;","GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0005524|ATP binding;GO:0016818|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;GO:0043139|5'-3' DNA helicase activity;","K15362","BRIP1, BACH1, FANCJ; fanconi anemia group J protein [EC:5.6.2.3]"]
["ENSRNOG00000011646",7,0.588946881,57,3.666834977,0.160614504,-2.638325917,{"v":6.42139e-09,"d":"6.42E-09"},{"v":9.25449e-09,"d":"9.25E-09"},"down","yes","Rem2","protein_coding","chr15:27933950-27938429:+","gi|259490277|ref|NP_073176.2|",1503,0,"GTP-binding protein REM 2 [Rattus norvegicus]","gi|259490276|ref|NM_022685.2|",1810,0,"Rattus norvegicus RAS (RAD and GEM) like GTP binding 2 (Rem2), mRNA","Q9WTY2",583,0,"GTP-binding protein REM 2","SPAC17H9.09c",85.5,{"v":1e-17,"d":"1.00E-17"},"COG1100","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.",".","GO:0005886|plasma membrane;GO:0016020|membrane;","GO:0003924|GTPase activity;GO:0005246|calcium channel regulator activity;GO:0005525|GTP binding;","K07848","REM2; Rad and Gem related GTP binding protein 2"]
["ENSRNOG00000064337",63,5.300521925,181,11.64380931,0.455222323,-1.135356789,{"v":7.63672e-09,"d":"7.64E-09"},{"v":1.09222e-08,"d":"1.09E-08"},"down","yes","ENSRNOG00000064337","lncRNA","chr17:66032603-66038403:+","gi|148705016|gb|EDL36963.1|",140,4e-07,"mCG1051106 [Mus musculus]","gi|240851455|gb|AC139609.2|",2206,0,"Rattus norvegicus CH230-381A11 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam10325","7TM_GPCR_Srz","Serpentine type 7TM GPCR chemoreceptor Srz. Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srz is a solo families amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srz appear to be under strong adaptive evolutionary pressure.",".",".",".",".","."]
["ENSRNOG00000013555",81,6.81495676,215,13.83104421,0.492729013,-1.021133672,{"v":7.68105e-09,"d":"7.68E-09"},{"v":1.09769e-08,"d":"1.10E-08"},"down","yes","Ankrd55","protein_coding","chr2:43883857-43983680:+","gi|564335271|ref|XP_006232002.1|",2896,0,"PREDICTED: ankyrin repeat domain-containing protein 55 isoform X2 [Rattus norvegicus]","gi|392871565|ref|NM_001270039.1|",2971,0,"Rattus norvegicus ankyrin repeat domain 55 (Ankrd55), mRNA",".",".",".",".","all2748",106,{"v":2e-23,"d":"2.00E-23"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).",".",".",".",".","."]
["ENSRNOG00000065633",4,0.336541075,47,3.023530595,0.111307316,-3.167379677,{"v":7.72715e-09,"d":"7.73E-09"},{"v":1.1037E-8,"d":"1.10E-08"},"down","yes","ENSRNOG00000065633","protein_coding","chr20:21710-43347:-","gi|672026979|ref|XP_008759124.1|",1951,0,"PREDICTED: zinc finger protein 431-like isoform X1 [Rattus norvegicus]","gi|755513322|ref|XM_011249631.1|",811,0,"PREDICTED: Mus musculus predicted gene, 35315 (Gm35315), transcript variant X3, mRNA","E9QAG8",562,0,"Zinc finger protein 431",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000003997",1,0.084135269,36,2.315895775,0.036329471,-4.782715827,{"v":8.03131e-09,"d":"8.03E-09"},{"v":1.14564E-8,"d":"1.15E-08"},"down","yes","Pld5","protein_coding","chr13:87896369-88232868:-","gi|880927737|ref|XP_012974586.1|",2786,0,"PREDICTED: inactive phospholipase D5 isoform X1 [Mesocricetus auratus]","gi|300794157|ref|NM_001191674.1|",1531,0,"Rattus norvegicus phospholipase D family, member 5 (Pld5), mRNA","Q3UNN8",956,0,"Inactive phospholipase D5",".",".",".",".","pfam13918","PLDc_3","PLD-like domain.","GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0003824|catalytic activity;","K16861","PLD5; inactive phospholipase D5"]
["ENSRNOG00000042086",42,3.533681283,139,8.941930908,0.39518101,-1.339414475,{"v":8.20262e-09,"d":"8.20E-09"},{"v":1.16947E-8,"d":"1.17E-08"},"down","yes","Rab26","protein_coding","chr10:13553395-13558030:-","gi|76363526|sp|P51156.2|RAB26_RAT",1255,{"v":3e-169,"d":"3.00E-169"},"RecName: Full=Ras-related protein Rab-26","gi|38303825|gb|BC061984.1|",1313,0,"Rattus norvegicus RAB26, member RAS oncogene family, mRNA (cDNA clone MGC:72316 IMAGE:5599180), complete cds","P51156",488,{"v":1e-170,"d":"1.00E-170"},"Ras-related protein Rab-26",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0016192|vesicle-mediated transport;GO:0017157|regulation of exocytosis;GO:0035272|exocrine system development;GO:0043001|Golgi to plasma membrane protein transport;GO:0045055|regulated exocytosis;GO:0099575|regulation of protein catabolic process at presynapse, modulating synaptic transmission;","GO:0000139|Golgi membrane;GO:0005768|endosome;GO:0005794|Golgi apparatus;GO:0030667|secretory granule membrane;GO:0031226|intrinsic component of plasma membrane;GO:0098993|anchored component of synaptic vesicle membrane;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0019002|GMP binding;","K07913","RAB26; Ras-related protein Rab-26"]
["ENSRNOG00000028611",79,6.646686223,211,13.57372246,0.489673061,-1.030109266,{"v":8.28008e-09,"d":"8.28E-09"},{"v":1.17959E-8,"d":"1.18E-08"},"down","yes","AABR07037203.1","protein_coding","chrX:15096359-15097909:-","gi|149067653|gb|EDM17205.1|",785,{"v":4E-95,"d":"4.00E-95"},"rCG39872, isoform CRA_e [Rattus norvegicus]","gi|58865843|ref|NM_001012137.1|",1458,0,"Rattus norvegicus fused in sarcoma RNA binding protein (Fus), mRNA","P56959",282,{"v":2e-86,"d":"2.00E-86"},"RNA-binding protein FUS",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.",".",".",".",".","."]
["ENSRNOG00000062469",24,2.019246448,100,6.433043818,0.31388663,-1.671684514,{"v":8.38149e-09,"d":"8.38E-09"},{"v":1.1931e-08,"d":"1.19E-08"},"down","yes","Ccdc194","protein_coding","chr16:18205095-18209283:-","gi|407263515|ref|XP_003945491.1|",558,{"v":6e-64,"d":"6.00E-64"},"PREDICTED: nestin [Mus musculus]","gi|755526175|ref|XM_011242347.1|",795,0,"PREDICTED: Mus musculus RIKEN cDNA C430049E01 gene (C430049E01Rik), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam15547","DUF4654","Domain of unknown function (DUF4654). This family of proteins is found in eukaryotes. Proteins in this family are typically between 145 and 169 amino acids in length. There is a conserved IDC sequence motif.",".",".",".",".","."]
["ENSRNOG00000025476",50,4.206763432,155,9.971217919,0.421890632,-1.245059041,{"v":8.8486e-09,"d":"8.85E-09"},{"v":1.25434E-8,"d":"1.25E-08"},"down","yes","Tmem252","protein_coding","chr1:222316795-222321943:+","gi|56090345|ref|NP_001007739.1|",863,{"v":1E-107,"d":"1.00E-107"},"transmembrane protein 252 [Rattus norvegicus]","gi|56090344|ref|NM_001007738.1|",2049,0,"Rattus norvegicus transmembrane protein 252 (Tmem252), mRNA","Q6AXS2",337,{"v":3e-109,"d":"3.00E-109"},"Transmembrane protein 252",".",".",".",".","pfam06797","DUF1229","Protein of unknown function (DUF1229). This family consists of several hypothetical proteins of around 415 residues in length which seem to be specific to the bacterium Leptospira interrogans.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000062997",19,1.598570104,88,5.66107856,0.282379071,-1.82429493,{"v":9.28261e-09,"d":"9.28E-09"},{"v":1.31245E-8,"d":"1.31E-08"},"down","yes","ENSRNOG00000062997","protein_coding","chr9:95976958-95981417:+","gi|37654232|gb|AAQ96221.1|",697,{"v":6e-172,"d":"6.00E-172"},"LRRGT00008 [Rattus norvegicus]","gi|46810386|gb|AC147047.2|",1090,0,"Mus musculus BAC clone RP23-97D19 from chromosome 6, complete sequence","P11260",305,{"v":8e-93,"d":"8.00E-93"},"LINE-1 retrotransposable element ORF1 protein",".",".",".",".","pfam02994","Transposase_22","L1 transposable element.",".",".",".",".","."]
["ENSRNOG00000008996",3,0.252405806,43,2.766208842,0.091246113,-3.454093079,{"v":9.97539e-09,"d":"9.98E-09"},{"v":1.40493E-8,"d":"1.40E-08"},"down","yes","Dpysl5","protein_coding","chr6:25575104-25659422:-","gi|12711692|ref|NP_075412.1|",3035,0,"dihydropyrimidinase-related protein 5 [Rattus norvegicus]","gi|12711691|ref|NM_023023.1|",4836,0,"Rattus norvegicus dihydropyrimidinase-like 5 (Dpysl5), mRNA","Q9JHU0",1173,0,"Dihydropyrimidinase-related protein 5","SMc01821",404,{"v":1e-124,"d":"1.00E-124"},"COG0044","pfam13594","Amidohydro_5","Amidohydrolase. This family of enzymes are a part of a large metal dependent hydrolase superfamily. The family includes Adenine deaminase EC:3.5.4.2 that hydrolyses adenine to form hypoxanthine and ammonia. Adenine deaminases reaction is important for adenine utilisation as a purine and also as a nitrogen source. This family also includes dihydroorotase and N-acetylglucosamine-6-phosphate deacetylases, EC:3.5.1.25 These enzymes catalyse the reaction N-acetyl-D-glucosamine 6-phosphate + H2O <=> D-glucosamine 6-phosphate + acetate. This family includes the catalytic domain of urease alpha subunit. Dihydroorotases (EC:3.5.2.3) are also included.","GO:0007411|axon guidance;GO:0030182|neuron differentiation;","GO:0005737|cytoplasm;GO:0030425|dendrite;GO:0032991|protein-containing complex;GO:0043025|neuronal cell body;","GO:0005515|protein binding;GO:0008017|microtubule binding;","K07529","DPYSL5, CRAM; dihydropyrimidinase-like 5"]
["ENSRNOG00000060689",63,5.300521925,180,11.57947887,0.457751336,-1.127363998,{"v":1.01811e-08,"d":"1.02E-08"},{"v":1.43316E-8,"d":"1.43E-08"},"down","yes","Parp11","protein_coding","chr4:160304905-160341946:+","gi|672051145|ref|XP_008761524.1|",1731,0,"PREDICTED: poly [ADP-ribose] polymerase 11 isoform X2 [Rattus norvegicus]","gi|672051144|ref|XM_008763302.1|",1360,0,"PREDICTED: Rattus norvegicus poly (ADP-ribose) polymerase family, member 11 (Parp11), transcript variant X2, mRNA","Q8CFF0",669,0,"Poly [ADP-ribose] polymerase 11",".",".",".",".","pfam00644","PARP","Poly(ADP-ribose) polymerase catalytic domain. Poly(ADP-ribose) polymerase catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The carboxyl-terminal region is the most highly conserved region of the protein. Experiments have shown that a carboxyl 40 kDa fragment is still catalytically active.","GO:0006998|nuclear envelope organization;GO:0008150|biological_process;GO:0070213|protein auto-ADP-ribosylation;","GO:0005575|cellular_component;GO:0005635|nuclear envelope;GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0016604|nuclear body;","GO:0003674|molecular_function;GO:0003950|NAD+ ADP-ribosyltransferase activity;GO:1990404|protein ADP-ribosylase activity;","K15259","PARP7S; poly [ADP-ribose] polymerase 7/11/12/13 [EC:2.4.2.30]"]
["ENSRNOG00000028616",20,1.682705373,90,5.789739437,0.290635769,-1.782715827,{"v":1.08483E-8,"d":"1.08E-08"},{"v":1.52393e-08,"d":"1.52E-08"},"down","yes","Pck1","protein_coding","chr3:161930256-161936191:+","gi|158430173|pdb|2QF2|A",3273,0,"Chain A, Rat Cytosolic Pepck In Complex With Oxaloacetic Acid And Gdp.","gi|61835220|ref|NM_198780.3|",2621,0,"Rattus norvegicus phosphoenolpyruvate carboxykinase 1 (Pck1), mRNA","P07379",1264,0,"Phosphoenolpyruvate carboxykinase, cytosolic [GTP]","CPn0851",622,0,"COG1274","pfam00821","PEPCK","Phosphoenolpyruvate carboxykinase. Catalyses the formation of phosphoenolpyruvate by decarboxylation of oxaloacetate.","GO:0006006|glucose metabolic process;GO:0006094|gluconeogenesis;GO:0006107|oxaloacetate metabolic process;GO:0006165|nucleoside diphosphate phosphorylation;GO:0006629|lipid metabolic process;GO:0007568|aging;GO:0009617|response to bacterium;GO:0014823|response to activity;GO:0018105|peptidyl-serine phosphorylation;GO:0019543|propionate catabolic process;GO:0032496|response to lipopolysaccharide;GO:0032868|response to insulin;GO:0032869|cellular response to insulin stimulus;GO:0033993|response to lipid;GO:0042593|glucose homeostasis;GO:0042594|response to starvation;GO:0043382|positive regulation of memory T cell differentiation;GO:0046327|glycerol biosynthetic process from pyruvate;GO:0046890|regulation of lipid biosynthetic process;GO:0051365|cellular response to potassium ion starvation;GO:0061402|positive regulation of transcription from RNA polymerase II promoter in response to acidic pH;GO:0070365|hepatocyte differentiation;GO:0070741|response to interleukin-6;GO:0071300|cellular response to retinoic acid;GO:0071320|cellular response to cAMP;GO:0071332|cellular response to fructose stimulus;GO:0071333|cellular response to glucose stimulus;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071377|cellular response to glucagon stimulus;GO:0071456|cellular response to hypoxia;GO:0071549|cellular response to dexamethasone stimulus;GO:1904640|response to methionine;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;","GO:0000287|magnesium ion binding;GO:0004550|nucleoside diphosphate kinase activity;GO:0004611|phosphoenolpyruvate carboxykinase activity;GO:0004613|phosphoenolpyruvate carboxykinase (GTP) activity;GO:0005525|GTP binding;GO:0019003|GDP binding;GO:0030145|manganese ion binding;GO:0031406|carboxylic acid binding;","K01596","E4.1.1.32, pckA, PCK; phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32]"]
["ENSRNOG00000025160",27,2.271652253,106,6.819026448,0.333134395,-1.585823778,{"v":1.12567E-8,"d":"1.13E-08"},{"v":1.57966e-08,"d":"1.58E-08"},"down","yes","Tlcd4","protein_coding","chr2:209289732-209341353:-","gi|209529652|ref|NP_001129351.1|",1374,0,"transmembrane protein 56 [Rattus norvegicus]","gi|672044036|ref|XM_006233246.2|",1282,0,"PREDICTED: Rattus norvegicus transmembrane protein 56 (Tmem56), transcript variant X3, mRNA","Q8CGF5",474,{"v":1E-165,"d":"1.00E-165"},"Transmembrane protein 56",".",".",".",".","pfam03798","TRAM_LAG1_CLN8","TLC domain.","GO:0008150|biological_process;GO:0055088|lipid homeostasis;","GO:0005575|cellular_component;GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;",".","."]
["ENSRNOG00000055383",24,2.019246448,99,6.36871338,0.317057202,-1.657184945,{"v":1.22432E-8,"d":"1.22E-08"},{"v":1.7128E-8,"d":"1.71E-08"},"down","yes","AABR07067762.1","protein_coding","chr9:56634648-56635789:+","gi|126723054|ref|NP_598282.2|",573,{"v":4e-72,"d":"4.00E-72"},"glycine cleavage system H protein, mitochondrial precursor [Rattus norvegicus]","gi|32362328|gb|AC103419.6|",350,0,"Rattus norvegicus 9 BAC CH230-145A24 (Children's Hospital Oakland Research Institute) complete sequence","Q5I0P2",225,{"v":1E-73,"d":"1.00E-73"},"Glycine cleavage system H protein, mitochondrial","TM0212",92.4,{"v":4e-23,"d":"4.00E-23"},"COG0509","pfam01597","GCV_H","Glycine cleavage H-protein. This is a family of glycine cleavage H-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyses the catabolism of glycine in eukaryotes. A lipoyl group is attached to a completely conserved lysine residue. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.",".",".",".",".","."]
["ENSRNOG00000068201",65,5.468792462,183,11.77247019,0.464540778,-1.106122851,{"v":1.29064E-8,"d":"1.29E-08"},{"v":1.80003e-08,"d":"1.80E-08"},"down","yes","ENSRNOG00000068201","protein_coding","chrX:17118816-17129381:-","gi|564322560|ref|XP_006227357.1|",1615,0,"PREDICTED: spindlin-2B-like isoform X1 [Rattus norvegicus]","gi|672032098|ref|XM_006227295.2|",1909,0,"PREDICTED: Rattus norvegicus similar to Spindlin-like protein 2 (SPIN-2) (RGD1565862), transcript variant X1, mRNA","Q5RA80",311,{"v":5e-98,"d":"5.00E-98"},"Spindlin-2",".",".",".",".","pfam02513","Spin-Ssty","Spin/Ssty Family. Spindlin (Spin) is a novel maternal transcript present in the unfertilised egg and early embryo. The Y-linked spermiogenesis -specific transcript (Ssty) is also expressed during gametogenesis and forms part of this Pfam family. Members of this family contain three copies of this 50 residue repeat. The repeat is predicted to contain four beta strands.",".",".",".",".","."]
["ENSRNOG00000011566",62,5.216386656,177,11.38648756,0.458120788,-1.126200065,{"v":1.38662e-08,"d":"1.39E-08"},{"v":1.92847e-08,"d":"1.93E-08"},"down","yes","Cecr2","protein_coding","chr4:153890206-153993451:+","gi|672050898|ref|XP_008761473.1|",6383,0,"PREDICTED: cat eye syndrome critical region protein 2 isoform X1 [Rattus norvegicus]","gi|672050897|ref|XM_008763251.1|",4838,0,"PREDICTED: Rattus norvegicus cat eye syndrome chromosome region, candidate 2 (Cecr2), transcript variant X1, mRNA","E9Q2Z1",2276,0,"Cat eye syndrome critical region protein 2 homolog","YGR252w",89,{"v":2e-17,"d":"2.00E-17"},"COG5076","pfam00439","Bromodomain","Bromodomain. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.","GO:0001842|neural fold formation;GO:0001843|neural tube closure;GO:0006338|chromatin remodeling;GO:0007338|single fertilization;GO:0021915|neural tube development;GO:0060122|inner ear receptor cell stereocilium organization;GO:0090102|cochlea development;GO:0097194|execution phase of apoptosis;","GO:0000791|euchromatin;GO:0005634|nucleus;GO:0031010|ISWI-type complex;GO:0090537|CERF complex;",".",".","."]
["ENSRNOG00000053638",32,2.692328597,116,7.462330829,0.36078923,-1.47077182,{"v":1.58519E-8,"d":"1.59E-08"},{"v":2.19566e-08,"d":"2.20E-08"},"down","yes","Clec12b","protein_coding","chr4:162827462-162838946:-","gi|157819437|ref|NP_001102823.1|",1367,0,"C-type lectin domain family 12 member B [Rattus norvegicus]","gi|157819436|ref|NM_001109353.1|",1487,0,"Rattus norvegicus C-type lectin domain family 12, member B (Clec12b), mRNA","Q149M0",473,{"v":3e-164,"d":"3.00E-164"},"C-type lectin domain family 12 member B",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0002769|natural killer cell inhibitory signaling pathway;GO:0045953|negative regulation of natural killer cell mediated cytotoxicity;GO:2000272|negative regulation of signaling receptor activity;","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0032991|protein-containing complex;","GO:0019903|protein phosphatase binding;GO:0030246|carbohydrate binding;GO:0030547|receptor inhibitor activity;","K17517","CLEC12B; C-type lectin domain family 12 member B"]
["ENSRNOG00000004806",75,6.310145148,201,12.93041808,0.488007821,-1.035023826,{"v":1.63782E-8,"d":"1.64E-08"},{"v":2.26394E-8,"d":"2.26E-08"},"down","yes","Strn","protein_coding","chr6:16335358-16417083:+","gi|564354630|ref|XP_006239684.1|",3826,0,"PREDICTED: striatin isoform X1 [Rattus norvegicus]","gi|672055150|ref|XM_006239622.2|",3091,0,"PREDICTED: Rattus norvegicus striatin, calmodulin binding protein (Strn), transcript variant X1, mRNA","P70483",1414,0,"Striatin",".",".",".",".","pfam08232","Striatin","Striatin family. Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (pfam00400) repeat domain. It acts as a scaffold protein and is involved in signalling pathways.","GO:0007626|locomotory behavior;GO:0008285|negative regulation of cell proliferation;GO:0016055|Wnt signaling pathway;GO:0016358|dendrite development;","GO:0005737|cytoplasm;GO:0005923|bicellular tight junction;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0030425|dendrite;GO:0032991|protein-containing complex;GO:0043025|neuronal cell body;GO:0043197|dendritic spine;GO:0045211|postsynaptic membrane;GO:0090443|FAR/SIN/STRIPAK complex;","GO:0005515|protein binding;GO:0005516|calmodulin binding;GO:0019904|protein domain specific binding;GO:0030331|estrogen receptor binding;GO:0044877|protein-containing complex binding;GO:0048306|calcium-dependent protein binding;GO:0051721|protein phosphatase 2A binding;GO:0070016|armadillo repeat domain binding;","K17608","STRN1_3_4; striatin 1/3/4"]
["ENSRNOG00000016760",63,5.300521925,178,11.450818,0.462894609,-1.111244333,{"v":1.80171e-08,"d":"1.80E-08"},{"v":2.48292e-08,"d":"2.48E-08"},"down","yes","Kctd19","protein_coding","chr19:33259970-33292006:-","gi|762006002|ref|NP_001292128.1|",4825,0,"potassium channel tetramerization domain containing 19 [Rattus norvegicus]","gi|672031234|ref|XM_008774227.1|",2893,0,"PREDICTED: Rattus norvegicus potassium channel tetramerization domain containing 19 (Kctd19), transcript variant X2, mRNA","Q562E2",1774,0,"BTB/POZ domain-containing protein KCTD19",".",".",".",".","pfam02214","BTB_2","BTB/POZ domain. In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.","GO:0051260|protein homooligomerization;",".",".",".","."]
["ENSRNOG00000028108",39,3.281275477,130,8.362956964,0.392358288,-1.349756419,{"v":2.05283E-8,"d":"2.05E-08"},{"v":2.81544E-8,"d":"2.82E-08"},"down","yes","Cytl1","protein_coding","chr14:73053877-73058886:-","gi|197384591|ref|NP_001128076.1|",634,{"v":6e-76,"d":"6.00E-76"},"cytokine-like protein 1 precursor [Rattus norvegicus]","gi|197384590|ref|NM_001134604.1|",1846,0,"Rattus norvegicus cytokine like 1 (Cytl1), mRNA","Q9NRR1",179,{"v":2E-51,"d":"2.00E-51"},"Cytokine-like protein 1",".",".",".",".","pfam15153","CYTL1","Cytokine-like protein 1. The function of this family of proteins, CYTL1, has not, as yet, been determined. However it is thought to be a secretory protein expressed in CD34+ haemopoietic cells. This family of proteins is found in eukaryotes. Proteins in this family are typically between 134 and 145 amino acids in length. There are two conserved sequence motifs: PPTCYSR and DDC.","GO:0002062|chondrocyte differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048839|inner ear development;GO:0050650|chondroitin sulfate proteoglycan biosynthetic process;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:1990079|cartilage homeostasis;",".",".","K25418","CYTL1; cytokine-like protein 1"]
["ENSRNOG00000006999",66,5.552927731,183,11.77247019,0.471687559,-1.084096544,{"v":2.20159e-08,"d":"2.20E-08"},{"v":3.0066e-08,"d":"3.01E-08"},"down","yes","Dnai4","protein_coding","chr5:117788464-117876127:-","gi|67078448|ref|NP_001019957.1|",3842,0,"WD repeat-containing protein 78 [Rattus norvegicus]","gi|67078447|ref|NM_001024786.1|",2315,0,"Rattus norvegicus WD repeat domain 78 (Wdr78), mRNA","Q4V8G4",1476,0,"WD repeat-containing protein 78",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.","GO:0002244|hematopoietic progenitor cell differentiation;GO:0003341|cilium movement;GO:0007018|microtubule-based movement;GO:0070286|axonemal dynein complex assembly;","GO:0005858|axonemal dynein complex;GO:0005930|axoneme;GO:0031514|motile cilium;","GO:0045503|dynein light chain binding;GO:0045504|dynein heavy chain binding;","K24723","DNAI4, WDR78; dynein axonemal intermediate chain 4"]
["ENSRNOG00000014673",65,5.468792462,181,11.64380931,0.469673825,-1.090268899,{"v":2.26541e-08,"d":"2.27E-08"},{"v":3.08834e-08,"d":"3.09E-08"},"down","yes","Eri2","protein_coding","chr1:174141993-174168665:-","gi|300798138|ref|NP_001178043.1|",3609,0,"ERI1 exoribonuclease 2 [Rattus norvegicus]","gi|300798137|ref|NM_001191114.1|",3448,0,"Rattus norvegicus ERI1 exoribonuclease family member 2 (Eri2), mRNA","Q5BKS4",1239,0,"ERI1 exoribonuclease 2","SPBC30B4.08",101,{"v":4e-22,"d":"4.00E-22"},"COG5018","pfam00929","RNase_T","Exonuclease. This family includes a variety of exonuclease proteins, such as ribonuclease T and the epsilon subunit of DNA polymerase III.;","GO:0000467|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);",".","GO:0000175|3'-5'-exoribonuclease activity;GO:0003676|nucleic acid binding;GO:0008270|zinc ion binding;","K18417","ERI2; ERI1 exoribonuclease 2 [EC:3.1.-.-]"]
["ENSRNOG00000010490",12,1.009623224,68,4.374469797,0.230798993,-2.115291166,{"v":2.60465e-08,"d":"2.60E-08"},{"v":3.52959e-08,"d":"3.53E-08"},"down","yes","Hes2","protein_coding","chr5:162667190-162668235:+","gi|9506775|ref|NP_062109.1|",610,{"v":4e-77,"d":"4.00E-77"},"transcription factor HES-2 [Rattus norvegicus]","gi|9506774|ref|NM_019236.1|",647,0,"Rattus norvegicus hes family bHLH transcription factor 2 (Hes2), mRNA","P35429",239,{"v":1E-78,"d":"1.00E-78"},"Transcription factor HES-2",".",".",".",".","pfam00010","HLH","Helix-loop-helix DNA-binding domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0009952|anterior/posterior pattern specification;GO:0045892|negative regulation of transcription, DNA-templated;GO:0050767|regulation of neurogenesis;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003690|double-stranded DNA binding;GO:0046983|protein dimerization activity;GO:1990837|sequence-specific double-stranded DNA binding;","K09087","HES2_6_7; hairy and enhancer of split 2/6/7"]
["ENSRNOG00000001036",8,0.673082149,57,3.666834977,0.183559433,-2.445680839,{"v":2.63387e-08,"d":"2.63E-08"},{"v":3.56564E-8,"d":"3.57E-08"},"down","yes","Rsph10b","protein_coding","chr12:10627435-10675167:-","gi|62078469|ref|NP_001013889.1|",4376,0,"radial spoke head 10 homolog B [Rattus norvegicus]","gi|62078468|ref|NM_001013867.1|",2875,0,"Rattus norvegicus radial spoke head 10 homolog B (Chlamydomonas) (Rsph10b), mRNA",".",".",".",".","slr1485",104,{"v":4e-23,"d":"4.00E-23"},"COG4642","pfam02493","MORN","MORN repeat. The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22).  #=GF CC   A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesised to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.",".",".",".","K25458","RSPH10B; radial spoke head protein 10B"]
["ENSRNOG00000070245",6,0.504811612,51,3.280852347,0.153865995,-2.700253667,{"v":2.69373e-08,"d":"2.69E-08"},{"v":3.64396e-08,"d":"3.64E-08"},"down","yes","Vstm1","protein_coding","chr1:65687375-65701188:+","gi|564296753|ref|XP_002725553.3|",895,{"v":1e-114,"d":"1.00E-114"},"PREDICTED: V-set and transmembrane domain-containing protein 1 [Rattus norvegicus]","gi|34368610|gb|AC103574.7|",915,0,"Rattus norvegicus 1 BAC CH230-205C19 (Children's Hospital Oakland Research Institute) complete sequence","Q6UX27",167,{"v":2E-46,"d":"2.00E-46"},"V-set and transmembrane domain-containing protein 1",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.",".",".",".",".","."]
["ENSRNOG00000032417",16,1.346164298,78,5.017774178,0.268279171,-1.898193044,{"v":2.78214E-8,"d":"2.78E-08"},{"v":3.7533e-08,"d":"3.75E-08"},"down","yes","Gabrp","protein_coding","chr10:18143038-18169516:-","gi|672066981|ref|XP_008765817.1|",2180,0,"PREDICTED: gamma-aminobutyric acid receptor subunit pi isoform X2 [Rattus norvegicus]","gi|672066978|ref|XM_008767594.1|",2791,0,"PREDICTED: Rattus norvegicus gamma-aminobutyric acid (GABA-A) receptor, pi (Gabrp), transcript variant X1, mRNA","O09028",837,0,"Gamma-aminobutyric acid receptor subunit pi",".",".",".",".","pfam02931","Neur_chan_LBD","Neurotransmitter-gated ion-channel ligand binding domain. This family is the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.","GO:0006821|chloride transport;GO:0007165|signal transduction;GO:0007268|chemical synaptic transmission;GO:0034220|ion transmembrane transport;GO:0042391|regulation of membrane potential;GO:0050877|nervous system process;GO:1902476|chloride transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0034707|chloride channel complex;GO:0043005|neuron projection;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:1902711|GABA-A receptor complex;","GO:0004890|GABA-A receptor activity;GO:0005230|extracellular ligand-gated ion channel activity;GO:0005254|chloride channel activity;GO:0030594|neurotransmitter receptor activity;","K05189","GABRP; gamma-aminobutyric acid receptor subunit pi"]
["ENSRNOG00000065699",25,2.103381716,99,6.36871338,0.330267919,-1.598291256,{"v":2.85306e-08,"d":"2.85E-08"},{"v":3.84707e-08,"d":"3.85E-08"},"down","yes","ENSRNOG00000065699","protein_coding","chr14:100606613-100607588:+","gi|913513001|ref|XP_013208915.1|",1103,{"v":4e-147,"d":"4.00E-147"},"PREDICTED: 60 kDa heat shock protein, mitochondrial [Microtus ochrogaster]","gi|302318920|ref|NG_023470.1|",638,0,"Rattus norvegicus heat shock protein 1, pseudogene 1 (Hspd1-ps1) on chromosome 14","P63039",430,{"v":2e-147,"d":"2.00E-147"},"60 kDa heat shock protein, mitochondrial","SPAC12G12.04",280,{"v":2e-89,"d":"2.00E-89"},"COG0459","pfam00118","Cpn60_TCP1","TCP-1/cpn60 chaperonin family. This family includes members from the HSP60 chaperone family and the TCP-1 (T-complex protein) family.",".",".",".",".","."]
["ENSRNOG00000018830",34,2.860599134,118,7.590991706,0.376841294,-1.407971033,{"v":3.45038e-08,"d":"3.45E-08"},{"v":4.62615E-8,"d":"4.63E-08"},"down","yes","Aff3","protein_coding","chr9:40404375-40857247:-","gi|300798499|ref|NP_001178816.1|",5197,0,"AF4/FMR2 family member 3 [Rattus norvegicus]","gi|300798498|ref|NM_001191887.1|",3772,0,"Rattus norvegicus AF4/FMR2 family, member 3 (Aff3), mRNA","P51827",1935,0,"AF4/FMR2 family member 3",".",".",".",".","pfam05110","AF-4","AF-4 proto-oncoprotein. This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.","GO:0006355|regulation of transcription, DNA-templated;GO:0010468|regulation of gene expression;GO:0034612|response to tumor necrosis factor;GO:0035116|embryonic hindlimb morphogenesis;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0016604|nuclear body;GO:0032783|ELL-EAF complex;","GO:0003690|double-stranded DNA binding;GO:0003700|DNA-binding transcription factor activity;","K15195","AFF3; AF4/FMR2 family member 3"]
["ENSRNOG00000013565",76,6.394280417,200,12.86608764,0.496987165,-1.008719502,{"v":3.501E-8,"d":"3.50E-08"},{"v":4.69056e-08,"d":"4.69E-08"},"down","yes","Zfp507","protein_coding","chr1:88438246-88468518:-","gi|148671058|gb|EDL03005.1|",4852,0,"mCG51010, isoform CRA_a, partial [Mus musculus]","gi|157823260|ref|NM_001106248.1|",4167,0,"Rattus norvegicus zinc finger protein 507 (Zfp507), mRNA","Q6ZPY5",1765,0,"Zinc finger protein 507",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;",".","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;",".","."]
["ENSRNOG00000001873",67,5.637062999,183,11.77247019,0.478834341,-1.062401473,{"v":3.71179e-08,"d":"3.71E-08"},{"v":4.9632e-08,"d":"4.96E-08"},"down","yes","P2rx6","protein_coding","chr11:83439924-83450481:-","gi|672071654|ref|XP_008767074.1|",1920,0,"PREDICTED: P2X purinoceptor 6 isoform X2 [Rattus norvegicus]","gi|227116254|ref|NM_012721.2|",2011,0,"Rattus norvegicus purinergic receptor P2X 6 (P2rx6), mRNA","P51579",699,0,"P2X purinoceptor 6",".",".",".",".","pfam00864","P2X_receptor","ATP P2X receptor.","GO:0033198|response to ATP;GO:0035590|purinergic nucleotide receptor signaling pathway;GO:0060079|excitatory postsynaptic potential;GO:0098655|cation transmembrane transport;","GO:0005639|integral component of nuclear inner membrane;GO:0005737|cytoplasm;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0030054|cell junction;GO:0043025|neuronal cell body;GO:0043197|dendritic spine;GO:0043235|receptor complex;GO:0098688|parallel fiber to Purkinje cell synapse;GO:0098978|glutamatergic synapse;GO:0099060|integral component of postsynaptic specialization membrane;","GO:0001614|purinergic nucleotide receptor activity;GO:0004931|extracellularly ATP-gated cation channel activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0044877|protein-containing complex binding;","K05221","P2RX6, P2RXL1; P2X purinoceptor 6"]
["ENSRNOG00000024557",48,4.038492895,146,9.392243975,0.429981686,-1.217652883,{"v":4.13274e-08,"d":"4.13E-08"},{"v":5.50443e-08,"d":"5.50E-08"},"down","yes","Cep112","protein_coding","chr10:93366136-93833131:+","gi|157786710|ref|NP_001099319.1|",4743,0,"centrosomal protein of 112 kDa [Rattus norvegicus]","gi|157786709|ref|NM_001105849.1|",3292,0,"Rattus norvegicus centrosomal protein 112kDa (Cep112), mRNA","Q5PR68",1714,0,"Centrosomal protein of 112 kDa",".",".",".",".","pfam14846","DUF4485","Domain of unknown function (DUF4485). This family is found in eukaryotes, and is approximately 90 amino acids in length.","GO:0097120|receptor localization to synapse;","GO:0005813|centrosome;GO:0005886|plasma membrane;GO:0060077|inhibitory synapse;","GO:0005515|protein binding;","K16767","CEP112; centrosomal protein CEP112"]
["ENSRNOG00000022391",27,2.271652253,102,6.561704695,0.346198489,-1.530328665,{"v":4.81429e-08,"d":"4.81E-08"},{"v":6.37632e-08,"d":"6.38E-08"},"down","yes","ENSRNOG00000022391","protein_coding","chrX:77646558-77678045:+","gi|293351051|ref|XP_002727665.1|",4092,0,"PREDICTED: zinc finger protein 711 [Rattus norvegicus]","gi|672088039|ref|XM_002730265.4|",2528,0,"PREDICTED: Rattus norvegicus zinc finger protein 711 (Zfp711), transcript variant X3, mRNA","A2ANX9",1459,0,"Zinc finger protein 711","SPAC144.09c",85.5,{"v":6e-17,"d":"6.00E-17"},"COG5048","pfam04704","Zfx_Zfy_act","Zfx / Zfy transcription activation region. Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0045893|positive regulation of transcription, DNA-templated;","GO:0005634|nucleus;GO:0005694|chromosome;","GO:0043035|chromatin insulator sequence binding;GO:0043565|sequence-specific DNA binding;GO:0046872|metal ion binding;","K24376","ZNF711; zinc finger protein 711"]
["ENSRNOG00000068345",36,3.028869671,121,7.78398302,0.389115658,-1.361729061,{"v":5.13485e-08,"d":"5.13E-08"},{"v":6.78274e-08,"d":"6.78E-08"},"down","yes","ENSRNOG00000068345","lncRNA","chr11:75790973-75796982:+","gi|26351813|dbj|BAC39543.1|",126,{"v":8e-13,"d":"8.00E-13"},"unnamed protein product [Mus musculus]","gi|672071385|ref|XM_006248507.2|",6003,0,"PREDICTED: Rattus norvegicus LIM domain containing preferred translocation partner in lipoma (Lpp), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam00387","PI-PLC-Y","Phosphatidylinositol-specific phospholipase C, Y domain. This associates with pfam00388 to form a single structural unit.",".",".",".",".","."]
["ENSRNOG00000064022",15,1.26202903,74,4.760452426,0.265106951,-1.915353595,{"v":5.2384e-08,"d":"5.24E-08"},{"v":6.9145e-08,"d":"6.91E-08"},"down","yes","ENSRNOG00000064022","lncRNA","chr10:5273404-5277370:+",".",".",".",".","gi|672024497|ref|XR_598611.1|",690,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102553451 (LOC102553451), transcript variant X3, ncRNA",".",".",".",".",".",".",".",".","pfam11477","PM0188","Sialyltransferase PMO188. PMO188 is a sialyltransferase from P.multocida. It transfers sialic acid from cytidine 5'-monophosphonuraminic acid to an acceptor sugar. It has important catalytic residues such as Asp141, His311, Glu338, Ser355 and Ser356.",".",".",".",".","."]
["ENSRNOG00000057458",72,6.057739343,191,12.28711369,0.49301565,-1.020294652,{"v":5.33558e-08,"d":"5.34E-08"},{"v":7.03424e-08,"d":"7.03E-08"},"down","yes","Oip5","protein_coding","chr3:106593760-106603250:-","gi|149023022|gb|EDL79916.1|",1258,{"v":2e-164,"d":"2.00E-164"},"similar to Opa-interacting protein 5 (predicted) [Rattus norvegicus]","gi|672017204|ref|XR_085783.4|",1480,0,"PREDICTED: Rattus norvegicus Opa interacting protein 5 (Oip5), misc_RNA","A2AQ14",388,{"v":9e-127,"d":"9.00E-127"},"Protein Mis18-beta",".",".",".",".","pfam03226","Yippee-Mis18","Yippee zinc-binding/DNA-binding /Mis18, centromere assembly. This family includes both Yippee-type proteins and Mis18 kinetochore proteins. Yippee are putative zinc-binding/DNA-binding proteins. Mis18 are proteins involved in the priming of centromeres for recruiting CENP-A. Mis18-alpha and beta form part of a small complex with Mis18-binding protein. Mis18-alpha is found to interact with DNA de-methylases through a Leu-rich region located at its carboxyl terminus.","GO:0051301|cell division;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0010369|chromocenter;GO:0015030|Cajal body;GO:0016607|nuclear speck;GO:0043231|intracellular membrane-bounded organelle;","GO:0042802|identical protein binding;GO:0046872|metal ion binding;","K11565","OIP5; opa-interacting protein 5"]
["ENSRNOG00000005038",40,3.365410746,129,8.298626526,0.405538282,-1.302089986,{"v":5.53183e-08,"d":"5.53E-08"},{"v":7.27711e-08,"d":"7.28E-08"},"down","yes","Ube2t","protein_coding","chr13:46403375-46414835:+","gi|226823227|ref|NP_001101814.2|",989,{"v":2e-127,"d":"2.00E-127"},"ubiquitin-conjugating enzyme E2 T [Rattus norvegicus]","gi|226823226|ref|NM_001108344.2|",966,0,"Rattus norvegicus ubiquitin-conjugating enzyme E2T (Ube2t), mRNA","Q9CQ37",365,{"v":5e-121,"d":"5.00E-121"},"Ubiquitin-conjugating enzyme E2 T","YDR092w",141,{"v":5e-38,"d":"5.00E-38"},"COG5078","pfam00179","UQ_con","Ubiquitin-conjugating enzyme. Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. TSG101 is one of several UBC homologues that lacks this active site cysteine.","GO:0000209|protein polyubiquitination;GO:0006281|DNA repair;GO:0006513|protein monoubiquitination;GO:0006974|cellular response to DNA damage stimulus;GO:0035519|protein K29-linked ubiquitination;GO:0044314|protein K27-linked ubiquitination;GO:0051865|protein autoubiquitination;GO:0070534|protein K63-linked ubiquitination;GO:0070936|protein K48-linked ubiquitination;GO:0070979|protein K11-linked ubiquitination;GO:0085020|protein K6-linked ubiquitination;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;","GO:0003682|chromatin binding;GO:0004842|ubiquitin-protein transferase activity;GO:0005524|ATP binding;GO:0031625|ubiquitin protein ligase binding;GO:0061631|ubiquitin conjugating enzyme activity;","K13960","UBE2T, HSPC150; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]"]
["ENSRNOG00000018394",2,0.168270537,36,2.315895775,0.072658942,-3.782715827,{"v":5.79662e-08,"d":"5.80E-08"},{"v":7.61992e-08,"d":"7.62E-08"},"down","yes","Chrdl2","protein_coding","chr1:154343201-154370640:+","gi|157820135|ref|NP_001101007.1|",2210,0,"chordin-like protein 2 precursor [Rattus norvegicus]","gi|157820134|ref|NM_001107537.1|",1529,0,"Rattus norvegicus chordin-like 2 (Chrdl2), mRNA","Q8VEA6",817,0,"Chordin-like protein 2",".",".",".",".","pfam00093","VWC","von Willebrand factor type C domain. The high cutoff was used to prevent overlap with pfam00094.","GO:0030154|cell differentiation;GO:0030514|negative regulation of BMP signaling pathway;",".",".","K17280","CHRDL2; chordin-like protein 2"]
["ENSRNOG00000022353",25,2.103381716,97,6.240052504,0.337077567,-1.568847478,{"v":5.95157e-08,"d":"5.95E-08"},{"v":7.81605e-08,"d":"7.82E-08"},"down","yes","Klk13","protein_coding","chr1:94165381-94177002:+","gi|281427274|ref|NP_001163876.1|",1383,0,"kallikrein-13 precursor [Rattus norvegicus]","gi|281427273|ref|NM_001170405.1|",1038,0,"Rattus norvegicus kallikrein related-peptidase 13 (Klk13), mRNA","Q9UKR3",419,{"v":2e-145,"d":"2.00E-145"},"Kallikrein-13","mlr3307",85.9,{"v":3e-18,"d":"3.00E-18"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0016485|protein processing;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0030141|secretory granule;","GO:0004175|endopeptidase activity;GO:0004252|serine-type endopeptidase activity;GO:0016787|hydrolase activity;","K09463","KLK13; kallikrein 13 [EC:3.4.21.119]"]
["ENSRNOG00000042347",57,4.795710313,162,10.42153099,0.460173301,-1.119750814,{"v":6.51034e-08,"d":"6.51E-08"},{"v":8.51701e-08,"d":"8.52E-08"},"down","yes","Zfp53","protein_coding","chr1:61284033-61314377:+","gi|157818837|ref|NP_001100938.1|",3245,0,"zinc finger protein 53 [Rattus norvegicus]","gi|157818836|ref|NM_001107468.1|",2536,0,"Rattus norvegicus zinc finger protein 53 (Zfp53), mRNA","Q8TAQ5",568,0,"Zinc finger protein 420",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000068352",1,0.084135269,32,2.058574022,0.040870655,-4.612790825,{"v":6.61003e-08,"d":"6.61E-08"},{"v":8.64536e-08,"d":"8.65E-08"},"down","yes","ENSRNOG00000068352","protein_coding","chr3:9485412-9489543:+","gi|392346165|ref|XP_001060674.3|",574,{"v":2E-70,"d":"2.00E-70"},"PREDICTED: uncharacterized protein LOC681186 isoform X3 [Rattus norvegicus]","gi|672016532|ref|XR_600102.1|",480,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102547612 (LOC102547612), transcript variant X2, ncRNA","Q62472",51.6,1e-06,"Vomeronasal secretory protein 2",".",".",".",".","pfam00061","Lipocalin","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.",".",".",".",".","."]
["ENSRNOG00000067344",51,4.290898701,150,9.649565728,0.444672726,-1.169184174,{"v":7.30771e-08,"d":"7.31E-08"},{"v":9.52355e-08,"d":"9.52E-08"},"down","yes","ENSRNOG00000067344","protein_coding","chr9:113440157-113676688:+","gi|672070366|ref|XP_008766739.1|",2337,0,"PREDICTED: zinc finger protein 431-like isoform X3 [Rattus norvegicus]","gi|672018984|ref|XR_600914.1|",1708,0,"PREDICTED: Rattus norvegicus zinc finger protein 120-like (LOC102557117), misc_RNA","Q6P3V2",673,0,"Zinc finger protein 585A",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000037211",26,2.187516985,98,6.304382942,0.34698352,-1.527060951,{"v":9.21575e-08,"d":"9.22E-08"},{"v":1.19104e-07,"d":"1.19E-07"},"down","yes","Kif14","protein_coding","chr13:47927044-47989164:+","gi|187957280|gb|AAI58133.1|",7624,0,"Kif14 protein [Mus musculus]","gi|755494483|ref|XM_006529729.2|",3644,0,"PREDICTED: Mus musculus kinesin family member 14 (Kif14), transcript variant X10, mRNA","L0N7N1",2940,0,"Kinesin-like protein KIF14","SPAC1834.07",227,{"v":6e-62,"d":"6.00E-62"},"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0001558|regulation of cell growth;GO:0007018|microtubule-based movement;GO:0007080|mitotic metaphase plate congression;GO:0008284|positive regulation of cell proliferation;GO:0010389|regulation of G2/M transition of mitotic cell cycle;GO:0021685|cerebellar granular layer structural organization;GO:0021693|cerebellar Purkinje cell layer structural organization;GO:0021695|cerebellar cortex development;GO:0021766|hippocampus development;GO:0021772|olfactory bulb development;GO:0021846|cell proliferation in forebrain;GO:0021987|cerebral cortex development;GO:0030155|regulation of cell adhesion;GO:0030334|regulation of cell migration;GO:0031146|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0031641|regulation of myelination;GO:0032147|activation of protein kinase activity;GO:0032467|positive regulation of cytokinesis;GO:0032487|regulation of Rap protein signal transduction;GO:0033624|negative regulation of integrin activation;GO:0034446|substrate adhesion-dependent cell spreading;GO:0043066|negative regulation of apoptotic process;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043523|regulation of neuron apoptotic process;GO:0043524|negative regulation of neuron apoptotic process;GO:0045184|establishment of protein localization;GO:0051301|cell division;GO:1903429|regulation of cell maturation;GO:2000045|regulation of G1/S transition of mitotic cell cycle;","GO:0005829|cytosol;GO:0005871|kinesin complex;GO:0005874|microtubule;GO:0005886|plasma membrane;GO:0030496|midbody;GO:0051233|spindle midzone;GO:0090543|Flemming body;","GO:0003777|microtubule motor activity;GO:0005524|ATP binding;GO:0008017|microtubule binding;GO:0008574|ATP-dependent microtubule motor activity, plus-end-directed;GO:0015631|tubulin binding;GO:0016887|ATPase activity;GO:0019901|protein kinase binding;GO:0030165|PDZ domain binding;","K17915","KIF14; kinesin family member 14"]
["ENSRNOG00000013046",53,4.459169238,153,9.842557042,0.453049875,-1.142258213,{"v":9.46877e-08,"d":"9.47E-08"},{"v":1.22229E-7,"d":"1.22E-07"},"down","yes","Tram2","protein_coding","chr9:23424232-23498689:-","gi|392342262|ref|XP_003754544.1|",1810,0,"PREDICTED: translocating chain-associated membrane protein 2 [Rattus norvegicus]","gi|672064628|ref|XM_002730009.5|",1390,0,"PREDICTED: Rattus norvegicus translocating chain-associating membrane protein 2 (LOC100361830), mRNA","Q924Z5",662,0,"Translocating chain-associated membrane protein 2",".",".",".",".","pfam03798","TRAM_LAG1_CLN8","TLC domain.","GO:0006616|SRP-dependent cotranslational protein targeting to membrane, translocation;GO:0032964|collagen biosynthetic process;GO:0045048|protein insertion into ER membrane;","GO:0030176|integral component of endoplasmic reticulum membrane;",".",".","."]
["ENSRNOG00000013698",4,0.336541075,42,2.701878404,0.124558187,-3.005108248,{"v":1.00085E-7,"d":"1.00E-07"},{"v":1.2883E-7,"d":"1.29E-07"},"down","yes","ENSRNOG00000013698","protein_coding","chrX:114965767-115005278:+","gi|564323265|ref|XP_006227579.1|",2198,0,"PREDICTED: testin [Rattus norvegicus]","gi|672032704|ref|XM_006227517.2|",1453,0,"PREDICTED: Rattus norvegicus similar to hypothetical protein (RGD1566387), transcript variant X1, mRNA","Q2LAP6",668,0,"Testin",".",".",".",".","pfam06297","PET","PET Domain. This domain is suggested to be involved in protein-protein interactions. The family is found in conjunction with pfam00412.","GO:0042127|regulation of cell proliferation;","GO:0005737|cytoplasm;GO:0005925|focal adhesion;","GO:0008270|zinc ion binding;",".","."]
["ENSRNOG00000007049",37,3.11300494,121,7.78398302,0.399924426,-1.322200697,{"v":1.01052E-7,"d":"1.01E-07"},{"v":1.29981E-7,"d":"1.30E-07"},"down","yes","Bcl11a","protein_coding","chr14:98030461-98124180:+","gi|300794336|ref|NP_001178612.1|",3539,0,"B-cell lymphoma/leukemia 11A [Rattus norvegicus]","gi|672077186|ref|XM_006251587.2|",3347,0,"PREDICTED: Rattus norvegicus B-cell CLL/lymphoma 11A (zinc finger protein) (Bcl11a), transcript variant X5, mRNA","Q9H165",1355,0,"B-cell lymphoma/leukemia 11A",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010976|positive regulation of neuron projection development;GO:0010977|negative regulation of neuron projection development;GO:0016925|protein sumoylation;GO:0030183|B cell differentiation;GO:0030217|T cell differentiation;GO:0048671|negative regulation of collateral sprouting;GO:0048672|positive regulation of collateral sprouting;GO:0050773|regulation of dendrite development;GO:1903860|negative regulation of dendrite extension;GO:1904800|negative regulation of neuron remodeling;GO:1905232|cellular response to L-glutamate;GO:2000171|negative regulation of dendrite development;GO:2000173|negative regulation of branching morphogenesis of a nerve;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0014069|postsynaptic density;GO:0016604|nuclear body;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001067|regulatory region nucleic acid binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0003712|transcription coregulator activity;GO:0003714|transcription corepressor activity;GO:0019901|protein kinase binding;GO:0046982|protein heterodimerization activity;","K22045","BCL11A; B-cell lymphoma/leukemia 11A"]
["ENSRNOG00000003346",49,4.122628164,145,9.327913537,0.441966807,-1.177990071,{"v":1.01128E-7,"d":"1.01E-07"},{"v":1.30049E-7,"d":"1.30E-07"},"down","yes","Fancb","protein_coding","chrX:29403771-29420192:-","gi|300795615|ref|NP_001178932.1|",4515,0,"Fanconi anemia group B protein [Rattus norvegicus]","gi|672087393|ref|XM_008773184.1|",2856,0,"PREDICTED: Rattus norvegicus Fanconi anemia, complementation group B (Fancb), transcript variant X2, mRNA","Q5XJY6",897,0,"Fanconi anemia group B protein homolog",".",".",".",".","pfam06398","Pex24p","Integral peroxisomal membrane peroxin. Peroxisomes play diverse roles in the cell, compartmentalising many activities related to lipid metabolizm and functioning in the decomposition of toxic hydrogen peroxide. Sequence similarity was identified between two hypothetical proteins and the peroxin integral membrane protein Pex24p.","GO:0008150|biological_process;GO:0036297|interstrand cross-link repair;GO:0071466|cellular response to xenobiotic stimulus;GO:0072757|cellular response to camptothecin;GO:1905168|positive regulation of double-strand break repair via homologous recombination;GO:1990414|replication-born double-strand break repair via sister chromatid exchange;GO:2000042|negative regulation of double-strand break repair via homologous recombination;","GO:0005575|cellular_component;GO:0043240|Fanconi anaemia nuclear complex;","GO:0003674|molecular_function;","K10889","FANCB; fanconi anemia group B protein"]
["ENSRNOG00000012591",1,0.084135269,31,1.994243584,0.042189063,-4.566987136,{"v":1.12335e-07,"d":"1.12E-07"},{"v":1.44121E-7,"d":"1.44E-07"},"down","yes","Pkd2l1","protein_coding","chr1:243032913-243070031:-","gi|672040343|ref|XP_008758621.1|",3781,0,"PREDICTED: polycystic kidney disease 2-like 1 protein isoform X1 [Rattus norvegicus]","gi|672040342|ref|XM_008760399.1|",3174,0,"PREDICTED: Rattus norvegicus polycystic kidney disease 2-like 1 (Pkd2l1), transcript variant X1, mRNA","A2A259",1321,0,"Polycystic kidney disease 2-like 1 protein",".",".",".",".","pfam08016","PKD_channel","Polycystin cation channel. This family contains the cation channel region of PKD1 and PKD2 proteins.","GO:0001581|detection of chemical stimulus involved in sensory perception of sour taste;GO:0006812|cation transport;GO:0007224|smoothened signaling pathway;GO:0009415|response to water;GO:0035725|sodium ion transmembrane transport;GO:0050912|detection of chemical stimulus involved in sensory perception of taste;GO:0050915|sensory perception of sour taste;GO:0050982|detection of mechanical stimulus;GO:0051262|protein tetramerization;GO:0051289|protein homotetramerization;GO:0070588|calcium ion transmembrane transport;GO:0071467|cellular response to pH;GO:0071468|cellular response to acidic pH;GO:0071805|potassium ion transmembrane transport;GO:0098662|inorganic cation transmembrane transport;","GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0031410|cytoplasmic vesicle;GO:0034703|cation channel complex;GO:0034704|calcium channel complex;GO:0043231|intracellular membrane-bounded organelle;GO:0043235|receptor complex;GO:0060170|ciliary membrane;GO:0097730|non-motile cilium;","GO:0005227|calcium activated cation channel activity;GO:0005261|cation channel activity;GO:0005262|calcium channel activity;GO:0005272|sodium channel activity;GO:0005509|calcium ion binding;GO:0008092|cytoskeletal protein binding;GO:0008324|cation transmembrane transporter activity;GO:0015269|calcium-activated potassium channel activity;GO:0033040|sour taste receptor activity;GO:0042802|identical protein binding;GO:0051371|muscle alpha-actinin binding;GO:0051393|alpha-actinin binding;","K04990","PKD2L1; polycystin 2L1"]
["ENSRNOG00000069359",16,1.346164298,74,4.760452426,0.282780748,-1.822244191,{"v":1.41989e-07,"d":"1.42E-07"},{"v":1.8076e-07,"d":"1.81E-07"},"down","yes","ENSRNOG00000069359","lncRNA","chr1:14671111-14673538:-","gi|148695124|gb|EDL27071.1|",271,{"v":3E-24,"d":"3.00E-24"},"mCG12966 [Mus musculus]","gi|22204781|emb|AL831793.4|",221,{"v":7e-110,"d":"7.00E-110"},"Mouse DNA sequence from clone RP23-9F23 on chromosome 4, complete sequence",".",".",".",".",".",".",".",".","pfam09997","DUF2238","Predicted membrane protein (DUF2238). This domain, found in various hypothetical bacterial proteins, has no known function.",".",".",".",".","."]
["ENSRNOG00000019472",30,2.524058059,105,6.754696009,0.37367456,-1.420145747,{"v":1.62264E-7,"d":"1.62E-07"},{"v":2.05227e-07,"d":"2.05E-07"},"down","yes","Ackr2","protein_coding","chr8:121561211-121573582:+","gi|55926223|ref|NP_511176.2|",1634,0,"atypical chemokine receptor 2 [Rattus norvegicus]","gi|672063550|ref|XM_008766664.1|",2729,0,"PREDICTED: Rattus norvegicus atypical chemokine receptor 2 (Ackr2), transcript variant X1, mRNA","O09027",630,0,"Atypical chemokine receptor 2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0006897|endocytosis;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007165|signal transduction;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0019722|calcium-mediated signaling;GO:0060326|cell chemotaxis;GO:0070098|chemokine-mediated signaling pathway;","GO:0005654|nucleoplasm;GO:0005769|early endosome;GO:0005829|cytosol;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0031965|nuclear membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0055037|recycling endosome;","GO:0005044|scavenger receptor activity;GO:0016493|C-C chemokine receptor activity;GO:0019957|C-C chemokine binding;","K04187","ACKR2, CCBP2; atypical chemokine receptor 2"]
["ENSRNOG00000004242",54,4.543304507,153,9.842557042,0.461597986,-1.115291166,{"v":1.64939e-07,"d":"1.65E-07"},{"v":2.08466e-07,"d":"2.08E-07"},"down","yes","Pole2","protein_coding","chr6:87674702-87699305:-","gi|281182710|ref|NP_001162579.1|",2733,0,"DNA polymerase epsilon subunit 2 [Rattus norvegicus]","gi|281182709|ref|NM_001169108.1|",1590,0,"Rattus norvegicus polymerase (DNA directed), epsilon 2, accessory subunit (Pole2), mRNA","O54956",1023,0,"DNA polymerase epsilon subunit 2",".",".",".",".","pfam04042","DNA_pol_E_B","DNA polymerase alpha/epsilon subunit B. This family contains a number of DNA polymerase subunits.  The B subunit of the DNA polymerase alpha plays an essential role at the initial stage of DNA replication in S. cerevisiae and is phosphorylated in a cell cycle-dependent manner. DNA polymerase epsilon is essential for cell viability and chromosomal DNA replication in budding yeast. In addition, DNA polymerase epsilon may be involved in DNA repair and cell-cycle checkpoint control. The enzyme consists of at least four subunits in mammalian cells as well as in yeast. The largest subunit of DNA polymerase epsilon is responsible for polymerase epsilon is responsible for polymerase activity. In mouse, the DNA polymerase epsilon subunit B is the second largest subunit of the DNA polymerase. A part of the N-terminal was found to be responsible for the interaction with SAP18. Experimental evidence suggests that this subunit may recruit histone deacetylase to the replication fork to modify the chromatin structure.","GO:0006261|DNA-dependent DNA replication;GO:0008150|biological_process;GO:0042276|error-prone translesion synthesis;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0008622|epsilon DNA polymerase complex;GO:0016604|nuclear body;GO:0043231|intracellular membrane-bounded organelle;","GO:0003674|molecular_function;GO:0003677|DNA binding;","K02325","POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]"]
["ENSRNOG00000006236",34,2.860599134,113,7.269339515,0.393515687,-1.345506946,{"v":1.83438E-7,"d":"1.83E-07"},{"v":2.30935E-7,"d":"2.31E-07"},"down","yes","Dsn1","protein_coding","chr3:145652737-145665856:-","gi|564343903|ref|XP_006235437.1|",1670,0,"PREDICTED: kinetochore-associated protein DSN1 homolog isoform X2 [Rattus norvegicus]","gi|672047617|ref|XM_006235375.2|",2066,0,"PREDICTED: Rattus norvegicus DSN1, MIS12 kinetochore complex component (Dsn1), transcript variant X1, mRNA","Q9CYC5",584,0,"Kinetochore-associated protein DSN1 homolog","SPCC576.08c",141,{"v":8e-36,"d":"8.00E-36"},"COG0098","pfam08202","MIS13","Mis12-Mtw1 protein family. Mis12-Mtw1 is a eukaryotic conserved kinetochore protein that is involved in chromosome segregation.","GO:0000070|mitotic sister chromatid segregation;GO:0051301|cell division;","GO:0000444|MIS12/MIND type complex;GO:0000776|kinetochore;GO:0000818|nuclear MIS12/MIND complex;GO:0001650|fibrillar center;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005829|cytosol;GO:0016604|nuclear body;",".","K11544","DSN1; kinetochore-associated protein DSN1"]
["ENSRNOG00000061050",46,3.870222358,137,8.813270031,0.439135797,-1.187260952,{"v":1.90813E-7,"d":"1.91E-07"},{"v":2.39831e-07,"d":"2.40E-07"},"down","yes","Mboat2","protein_coding","chr6:41471161-41593485:+","gi|189163518|ref|NP_001101486.2|",2687,0,"membrane-bound O-acyltransferase domain-containing protein 2 [Rattus norvegicus]","gi|189163517|ref|NM_001108016.2|",2835,0,"Rattus norvegicus membrane bound O-acyltransferase domain containing 2 (Mboat2), mRNA","Q3T1J2",1018,0,"Membrane-bound O-acyltransferase domain-containing protein 2","YOR175c",176,{"v":2E-45,"d":"2.00E-45"},"COG5202","pfam03062","MBOAT","MBOAT, membrane-bound O-acyltransferase family. The MBOAT (membrane bound O-acyl transferase) family of membrane proteins contains a variety of acyltransferase enzymes. A conserved histidine has been suggested to be the active site residue.","GO:0008654|phospholipid biosynthetic process;GO:0030258|lipid modification;GO:0032330|regulation of chondrocyte differentiation;GO:0036150|phosphatidylserine acyl-chain remodeling;GO:0036151|phosphatidylcholine acyl-chain remodeling;GO:0036152|phosphatidylethanolamine acyl-chain remodeling;","GO:0005789|endoplasmic reticulum membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0003841|1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0016746|transferase activity, transferring acyl groups;GO:0047184|1-acylglycerophosphocholine O-acyltransferase activity;","K13517","MBOAT1_2; lysophospholipid acyltransferase 1/2 [EC:2.3.1.51 2.3.1.-]"]
["ENSRNOG00000026053",22,1.85097591,87,5.596748122,0.330723461,-1.596302702,{"v":2.0112e-07,"d":"2.01E-07"},{"v":2.52377e-07,"d":"2.52E-07"},"down","yes","Grem1","protein_coding","chr3:100512313-100524082:-","gi|585648865|ref|XP_006883110.1|",775,{"v":1E-91,"d":"1.00E-91"},"PREDICTED: gremlin-1 isoform X1 [Elephantulus edwardii]","gi|393794769|ref|NM_019282.3|",3656,0,"Rattus norvegicus gremlin 1 (Grem1), mRNA","O35793",302,{"v":5e-93,"d":"5.00E-93"},"Gremlin-1",".",".",".",".","pfam03045","DAN","DAN domain. This domain contains 9 conserved cysteines and is extracellular. Therefore the cysteines may form disulphide bridges. This family of proteins has been termed the DAN family after the first member to be reported. This family includes DAN, Cerberus and Gremlin. The gremlin protein is an antagonist of bone morphogenetic protein signaling. It is postulated that all members of this family antagonise different TGF beta pfam00019 ligands. Recent work shows that the DAN protein is not an efficient antagonist of BMP-2/4 class signals, we found that DAN was able to interact with GDF-5 in a frog embryo assay, suggesting that DAN may regulate signaling by the GDF-5/6/7 class of BMPs in vivo.","GO:0000902|cell morphogenesis;GO:0001525|angiogenesis;GO:0002042|cell migration involved in sprouting angiogenesis;GO:0002092|positive regulation of receptor internalization;GO:0002689|negative regulation of leukocyte chemotaxis;GO:0003257|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation;GO:0003337|mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0006915|apoptotic process;GO:0007165|signal transduction;GO:0007171|activation of transmembrane receptor protein tyrosine kinase activity;GO:0007267|cell-cell signaling;GO:0008284|positive regulation of cell proliferation;GO:0009887|animal organ morphogenesis;GO:0009954|proximal/distal pattern formation;GO:0010717|regulation of epithelial to mesenchymal transition;GO:0030199|collagen fibril organization;GO:0030308|negative regulation of cell growth;GO:0030326|embryonic limb morphogenesis;GO:0030502|negative regulation of bone mineralization;GO:0030514|negative regulation of BMP signaling pathway;GO:0032331|negative regulation of chondrocyte differentiation;GO:0033689|negative regulation of osteoblast proliferation;GO:0038098|sequestering of BMP from receptor via BMP binding;GO:0043066|negative regulation of apoptotic process;GO:0043542|endothelial cell migration;GO:0045668|negative regulation of osteoblast differentiation;GO:0045766|positive regulation of angiogenesis;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046851|negative regulation of bone remodeling;GO:0048263|determination of dorsal identity;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051893|regulation of focal adhesion assembly;GO:0051973|positive regulation of telomerase activity;GO:0060173|limb development;GO:0060394|negative regulation of pathway-restricted SMAD protein phosphorylation;GO:0060676|ureteric bud formation;GO:0061098|positive regulation of protein tyrosine kinase activity;GO:0090027|negative regulation of monocyte chemotaxis;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0090190|positive regulation of branching involved in ureteric bud morphogenesis;GO:0090291|negative regulation of osteoclast proliferation;GO:1900086|positive regulation of peptidyl-tyrosine autophosphorylation;GO:1900155|negative regulation of bone trabecula formation;GO:1900158|negative regulation of bone mineralization involved in bone maturation;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:2000273|positive regulation of signaling receptor activity;GO:2000727|positive regulation of cardiac muscle cell differentiation;","GO:0005615|extracellular space;GO:0009986|cell surface;","GO:0005125|cytokine activity;GO:0005515|protein binding;GO:0030297|transmembrane receptor protein tyrosine kinase activator activity;GO:0036122|BMP binding;GO:0042803|protein homodimerization activity;GO:0043184|vascular endothelial growth factor receptor 2 binding;GO:0048018|receptor ligand activity;","K23318","GREM; gremlin"]
["ENSRNOG00000069755",3,0.252405806,37,2.380226213,0.106042781,-3.23728169,{"v":2.29942e-07,"d":"2.30E-07"},{"v":2.86827E-7,"d":"2.87E-07"},"down","yes","Np4","protein_coding","chr16:70342529-70497202:-","gi|564389779|ref|XP_006253428.1|",564,{"v":5E-71,"d":"5.00E-71"},"PREDICTED: neutrophil antibiotic peptide NP-4 isoform X1 [Rattus norvegicus]","gi|564389778|ref|XM_006253366.1|",435,0,"PREDICTED: Rattus norvegicus defensin NP-4 precursor (Np4), transcript variant X1, mRNA","Q62714",158,{"v":5e-48,"d":"5.00E-48"},"Neutrophil antibiotic peptide NP-4",".",".",".",".","pfam00879","Defensin_propep","Defensin propeptide.",".",".",".",".","."]
["ENSRNOG00000021693",60,5.048116119,163,10.48586142,0.481421212,-1.054628384,{"v":2.42352E-7,"d":"2.42E-07"},{"v":3.01478e-07,"d":"3.01E-07"},"down","yes","Fam149a","protein_coding","chr16:46854635-46912066:+","gi|109503396|ref|XP_341439.3|",3656,0,"PREDICTED: protein FAM149A isoform X2 [Rattus norvegicus]","gi|672080227|ref|XM_341438.6|",3023,0,"PREDICTED: Rattus norvegicus family with sequence similarity 149, member A (Fam149a), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam12516","DUF3719","Protein of unknown function (DUF3719). This domain family is found in eukaryotes, and is approximately 70 amino acids in length. There is a conserved HLR sequence motif. There are two completely conserved residues (W and H) that may be functionally important.",".",".",".","K24653","FAM149; primary cilium assembly protein FAM149"]
["ENSRNOG00000036682",25,2.103381716,93,5.982730751,0.351575527,-1.508093447,{"v":2.52573e-07,"d":"2.53E-07"},{"v":3.13548E-7,"d":"3.14E-07"},"down","yes","Pycr1","protein_coding","chr10:105917680-105922549:-","gi|672070187|ref|XP_008766697.1|",1720,0,"PREDICTED: pyrroline-5-carboxylate reductase 1, mitochondrial isoform X3 [Rattus norvegicus]","gi|672070186|ref|XM_008768475.1|",1083,0,"PREDICTED: Rattus norvegicus pyrroline-5-carboxylate reductase 1 (Pycr1), transcript variant X4, mRNA","Q922W5",610,0,"Pyrroline-5-carboxylate reductase 1, mitochondrial","CAC3252",192,{"v":1E-54,"d":"1.00E-54"},"COG0345","pfam14748","P5CR_dimer","Pyrroline-5-carboxylate reductase dimerization. Pyrroline-5-carboxylate reductase consists of two domains, an N-terminal catalytic domain (pfam03807) and a C-terminal dimerization domain. This is the dimerization domain.","GO:0006561|proline biosynthetic process;GO:0034599|cellular response to oxidative stress;GO:0051881|regulation of mitochondrial membrane potential;GO:0055129|L-proline biosynthetic process;GO:1903206|negative regulation of hydrogen peroxide-induced cell death;","GO:0005739|mitochondrion;","GO:0004735|pyrroline-5-carboxylate reductase activity;GO:0042802|identical protein binding;","K00286","proC; pyrroline-5-carboxylate reductase [EC:1.5.1.2]"]
["ENSRNOG00000010868",34,2.860599134,112,7.205009077,0.39702922,-1.332682906,{"v":2.54705E-7,"d":"2.55E-07"},{"v":3.16051E-7,"d":"3.16E-07"},"down","yes","Rims4","protein_coding","chr3:152524095-152584780:-","gi|33942097|ref|NP_898844.1|",1426,0,"regulating synaptic membrane exocytosis protein 4 [Mus musculus]","gi|672047994|ref|XM_008762471.1|",1845,0,"PREDICTED: Rattus norvegicus regulating synaptic membrane exocytosis 4 (Rims4), transcript variant X1, mRNA","P60191",553,0,"Regulating synaptic membrane exocytosis protein 4",".",".",".",".","pfam00168","C2","C2 domain.","GO:0006836|neurotransmitter transport;GO:0006887|exocytosis;GO:0007269|neurotransmitter secretion;GO:0042391|regulation of membrane potential;GO:0050807|regulation of synapse organization;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0045202|synapse;GO:0097060|synaptic membrane;GO:0098793|presynapse;GO:0098978|glutamatergic synapse;","GO:0031267|small GTPase binding;GO:0044325|ion channel binding;","K15299","RIMS4, RIM4; regulating synaptic membrane exocytosis protein 4"]
["ENSRNOG00000002379",21,1.766840642,84,5.403756808,0.32696524,-1.612790825,{"v":2.66209e-07,"d":"2.66E-07"},{"v":3.29734e-07,"d":"3.30E-07"},"down","yes","ENSRNOG00000002379","protein_coding","chrX:132821347-132985668:-","gi|67846068|ref|NP_001020065.1|",936,{"v":2E-120,"d":"2.00E-120"},"placenta-specific protein 1 precursor [Rattus norvegicus]","gi|298908373|emb|FQ228726.1|",1351,0,"Rattus norvegicus TL0ADA52YG08 mRNA sequence","Q4V7E2",365,{"v":6e-122,"d":"6.00E-122"},"Placenta-specific protein 1",".",".",".",".","pfam00100","Zona_pellucida","Zona pellucida-like domain.","GO:0001890|placenta development;GO:0090214|spongiotrophoblast layer developmental growth;","GO:0005576|extracellular region;",".","K25718","PLAC1; placenta-specific protein 1"]
["ENSRNOG00000060520",41,3.449546015,126,8.105635211,0.425573804,-1.232518744,{"v":2.68234e-07,"d":"2.68E-07"},{"v":3.32081e-07,"d":"3.32E-07"},"down","yes","AABR07048387.1","protein_coding","chr5:73866334-73956444:-","gi|672019425|ref|XP_008774197.1|",6948,0,"PREDICTED: uncharacterized protein C9orf84 homolog [Rattus norvegicus]","gi|672052764|ref|XM_008763751.1|",4045,0,"PREDICTED: Rattus norvegicus hypothetical protein LOC686050 (LOC686050), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam08928","DUF1910","Domain of unknown function (DUF1910). This domain is found in a set of hypothetical bacterial proteins.",".",".",".",".","."]
["ENSRNOG00000017581",54,4.543304507,151,9.713896166,0.467711867,-1.096308062,{"v":2.91214e-07,"d":"2.91E-07"},{"v":3.59713e-07,"d":"3.60E-07"},"down","yes","RGD1306227","protein_coding","chr2:51555432-51577085:+","gi|62078805|ref|NP_001014059.1|",3421,0,"uncharacterized protein C5orf34 homolog [Rattus norvegicus]","gi|62078804|ref|NM_001014037.1|",2299,0,"Rattus norvegicus similar to 4833420G17Rik protein (RGD1306227), mRNA",".",".",".",".",".",".",".",".","pfam15025","DUF4524","Domain of unknown function (DUF4524). This family of proteins is found in eukaryotes. Proteins in this family are typically between 197 and 638 amino acids in length.This is the N-terminal domain of the member proteins. The human gene is from C5orf34.",".",".",".",".","."]
["ENSRNOG00000024456",61,5.132251387,164,10.55019186,0.486460479,-1.039605492,{"v":3.07384e-07,"d":"3.07E-07"},{"v":3.78827e-07,"d":"3.79E-07"},"down","yes","Radil","protein_coding","chr12:12024395-12088540:+","gi|149034989|gb|EDL89709.1|",5256,0,"rCG42648, isoform CRA_b [Rattus norvegicus]","gi|575771879|ref|NM_001289588.1|",2951,0,"Mus musculus Ras association and DIL domains (Radil), transcript variant 1, mRNA","Q69Z89",1917,0,"Ras-associating and dilute domain-containing protein",".",".",".",".","pfam01843","DIL","DIL domain. The DIL domain has no known function.","GO:0001755|neural crest cell migration;GO:0007165|signal transduction;GO:0034446|substrate adhesion-dependent cell spreading;","GO:0005874|microtubule;GO:0032991|protein-containing complex;","GO:0051020|GTPase binding;",".","."]
["ENSRNOG00000000542",1,0.084135269,29,1.865582707,0.045098654,-4.47077182,{"v":3.25767e-07,"d":"3.26E-07"},{"v":4.00395e-07,"d":"4.00E-07"},"down","yes","Dnah8","protein_coding","chr20:8692963-8946772:+","gi|14335446|gb|AAK60621.1|AF356520_1",23278,0,"axonemal dynein heavy chain 8 long form [Mus musculus]","gi|755555913|ref|XM_006523588.2|",10842,0,"PREDICTED: Mus musculus dynein, axonemal, heavy chain 8 (Dnah8), transcript variant X1, mRNA","Q91XQ0",8968,0,"Dynein heavy chain 8, axonemal","YKR054c",641,0,"COG5245","pfam03028","Dynein_heavy","Dynein heavy chain and region D6 of dynein motor. This family represents the C-terminal region of dynein heavy chain. The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained.","GO:0007018|microtubule-based movement;GO:0008150|biological_process;GO:0036158|outer dynein arm assembly;","GO:0005575|cellular_component;GO:0005874|microtubule;GO:0005930|axoneme;GO:0030286|dynein complex;GO:0036126|sperm flagellum;GO:0036157|outer dynein arm;GO:0097228|sperm principal piece;","GO:0003674|molecular_function;GO:0005524|ATP binding;GO:0008569|ATP-dependent microtubule motor activity, minus-end-directed;GO:0045505|dynein intermediate chain binding;GO:0051959|dynein light intermediate chain binding;","K10408","DNAH; dynein axonemal heavy chain"]
["ENSRNOG00000021265",49,4.122628164,141,9.070591784,0.454504873,-1.137632334,{"v":3.28311e-07,"d":"3.28E-07"},{"v":4.03431e-07,"d":"4.03E-07"},"down","yes","Cds2","protein_coding","chr3:119515000-119553541:+","gi|149023367|gb|EDL80261.1|",2205,0,"CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 [Rattus norvegicus]","gi|16758453|ref|NM_053643.1|",1374,0,"Rattus norvegicus CDP-diacylglycerol synthase 2 (Cds2), mRNA","Q91XU8",847,0,"Phosphatidate cytidylyltransferase 2","SPBC13A2.03",307,{"v":2E-95,"d":"2.00E-95"},"COG0575","pfam01148","CTP_transf_1","Cytidylyltransferase family. The members of this family are integral membrane protein cytidylyltransferases. The family includes phosphatidate cytidylyltransferase EC:2.7.7.41 as well as Sec59 from yeast. Sec59 is a dolichol kinase EC:2.7.1.108.","GO:0016024|CDP-diacylglycerol biosynthetic process;GO:0140042|lipid droplet formation;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0004605|phosphatidate cytidylyltransferase activity;","K00981","E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41]"]
["ENSRNOG00000011478",46,3.870222358,135,8.684609155,0.445641512,-1.166044466,{"v":3.46481e-07,"d":"3.46E-07"},{"v":4.24704e-07,"d":"4.25E-07"},"down","yes","ENSRNOG00000011478","protein_coding","chr8:104716067-104723617:-","gi|672023283|ref|XP_008756080.1|",1714,0,"PREDICTED: atypical chemokine receptor 4 isoform X1 [Rattus norvegicus]","gi|672023284|ref|XM_006226547.2|",1669,0,"PREDICTED: Rattus norvegicus atypical chemokine receptor 4 (Ackr4), transcript variant X2, mRNA","Q924I3",626,0,"Atypical chemokine receptor 4",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0006897|endocytosis;GO:0006955|immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0019722|calcium-mediated signaling;GO:0060326|cell chemotaxis;GO:0070098|chemokine-mediated signaling pathway;","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0004950|chemokine receptor activity;GO:0005044|scavenger receptor activity;GO:0016493|C-C chemokine receptor activity;GO:0019957|C-C chemokine binding;","K04186","ACKR4, CCRL1, CCR11; atypical chemokine receptor 4"]
["ENSRNOG00000054311",20,1.682705373,81,5.210765493,0.322928632,-1.630712733,{"v":3.51503e-07,"d":"3.52E-07"},{"v":4.30473e-07,"d":"4.30E-07"},"down","yes","ENSRNOG00000054311","lncRNA","chr12:36918224-36920511:-",".",".",".",".","gi|672026799|ref|XR_339554.2|",961,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102551526 (LOC102551526), ncRNA",".",".",".",".",".",".",".",".","pfam01027","Bax1-I","Inhibitor of apoptosis-promoting Bax1. Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner.",".",".",".",".","."]
["ENSRNOG00000068603",38,3.197140209,119,7.655322144,0.417636273,-1.259681075,{"v":3.66194e-07,"d":"3.66E-07"},{"v":4.47658e-07,"d":"4.48E-07"},"down","yes","ENSRNOG00000068603","lncRNA","chr12:19323608-19326012:-","gi|148701441|gb|EDL33388.1|",210,{"v":2E-16,"d":"2.00E-16"},"mCG1045525, partial [Mus musculus]","gi|755477074|ref|XR_861418.1|",278,{"v":2e-141,"d":"2.00E-141"},"PREDICTED: Mus musculus uncharacterized LOC105242538 (LOC105242538), ncRNA",".",".",".",".",".",".",".",".","pfam00336","DNA_pol_viral_C","DNA polymerase (viral) C-terminal domain.",".",".",".",".","."]
["ENSRNOG00000021269",9,0.757217418,54,3.473843662,0.217976827,-2.197753326,{"v":3.76633e-07,"d":"3.77E-07"},{"v":4.59491e-07,"d":"4.59E-07"},"down","yes","Chgb","protein_coding","chr3:120043738-120057166:+","gi|564343142|ref|XP_006235134.1|",2695,0,"PREDICTED: secretogranin-1 isoform X1 [Rattus norvegicus]","gi|672046753|ref|XM_006235072.2|",2226,0,"PREDICTED: Rattus norvegicus chromogranin B (secretogranin 1) (Chgb), transcript variant X1, mRNA","O35314",1040,0,"Secretogranin-1",".",".",".",".","pfam01271","Granin","Granin (chromogranin or secretogranin).",".","GO:0005615|extracellular space;GO:0030141|secretory granule;",".","K19991","CHGB; chromogranin-B"]
["ENSRNOG00000065744",0,0.042067634,27,1.736921831,0.024219647,-5.367678327,{"v":4.07141e-07,"d":"4.07E-07"},{"v":4.95158e-07,"d":"4.95E-07"},"down","yes","ENSRNOG00000065744","lncRNA","chr3:1379622-1382303:+","gi|149021375|gb|EDL78838.1|",585,{"v":4e-67,"d":"4.00E-67"},"rCG59047, partial [Rattus norvegicus]","gi|86439999|gb|AC112083.7|",417,0,"Rattus norvegicus BAC CH230-288C21 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P11369",195,{"v":6e-53,"d":"6.00E-53"},"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam00607","Gag_p24","gag gene protein p24 (core nucleocapsid protein). p24 forms inner protein layer of the nucleocapsid. ELISA tests for p24 is the most commonly used method to demonstrate virus replication both in vivo and in vitro.",".",".",".",".","."]
["ENSRNOG00000031469",11,0.925487955,59,3.795495853,0.243838484,-2.036002256,{"v":4.20559e-07,"d":"4.21E-07"},{"v":5.10906e-07,"d":"5.11E-07"},"down","yes","Glb1l3","protein_coding","chr8:25179165-25220904:-","gi|164519029|ref|NP_001019529.2|",3366,0,"beta-galactosidase-1-like protein 3 precursor [Rattus norvegicus]","gi|66730518|ref|NM_001024358.1|",2306,0,"Rattus norvegicus galactosidase, beta 1-like 3 (Glb1l3), mRNA","Q5XIL5",1272,0,"Beta-galactosidase-1-like protein 3","XF0840",345,{"v":3e-107,"d":"3.00E-107"},"COG1874","pfam01301","Glyco_hydro_35","Glycosyl hydrolases family 35.","GO:0005975|carbohydrate metabolic process;","GO:0005773|vacuole;","GO:0004565|beta-galactosidase activity;","K25543","GLB1L; beta-galactosidase-1-like protein [EC:3.2.1.-]"]
["ENSRNOG00000042165",59,4.96398085,159,10.22853967,0.485306897,-1.043030731,{"v":4.33032e-07,"d":"4.33E-07"},{"v":5.25121e-07,"d":"5.25E-07"},"down","yes","Colca2","protein_coding","chr8:51588237-51603855:-","gi|564309980|ref|XP_006226458.1|",986,{"v":6e-118,"d":"6.00E-118"},"PREDICTED: colorectal cancer-associated protein 2 isoform X1 [Rattus norvegicus]","gi|755481127|ref|XR_405679.2|",1296,0,"PREDICTED: Mus musculus predicted gene, 32819 (Gm32819), ncRNA","A8K830",122,{"v":2e-29,"d":"2.00E-29"},"Colorectal cancer-associated protein 2",".",".",".",".","pfam09310","PD-C2-AF1","POU domain, class 2, associating factor 1. Members of this family are transcriptional coactivators that specifically associate with either OCT1 or OCT2, through recognition of their POU domains. They are essential for the response of B-cells to antigens and required for the formation of germinal centres.",".","GO:0005737|cytoplasm;",".",".","."]
["ENSRNOG00000009691",4,0.336541075,39,2.508887089,0.134139586,-2.898193044,{"v":4.58858e-07,"d":"4.59E-07"},{"v":5.54709e-07,"d":"5.55E-07"},"down","yes","Lrrn2","protein_coding","chr13:44321364-44382482:+","gi|293651541|ref|NP_001170839.1|",3577,0,"leucine-rich repeat neuronal protein 2 precursor [Rattus norvegicus]","gi|293651540|ref|NM_001177368.1|",3281,0,"Rattus norvegicus leucine rich repeat neuronal 2 (Lrrn2), mRNA","O75325",1158,0,"Leucine-rich repeat neuronal protein 2","alr0124_1",72.4,{"v":4e-12,"d":"4.00E-12"},"COG4886","pfam07679","I-set","Immunoglobulin I-set domain.",".","GO:0005615|extracellular space;GO:0016021|integral component of membrane;GO:0031012|extracellular matrix;",".","K24492","LRRN1_2_3; leucine-rich repeat neuronal protein 1/2/3"]
["ENSRNOG00000070558",16,1.346164298,71,4.567461111,0.29472923,-1.762537945,{"v":4.7084E-7,"d":"4.71E-07"},{"v":5.68311e-07,"d":"5.68E-07"},"down","yes","ENSRNOG00000070558","protein_coding","chr15:36677527-36701211:-","gi|568900759|ref|XP_006543249.1|",1599,0,"PREDICTED: uncharacterized protein Gm4131 [Mus musculus]","gi|672078538|ref|XM_006252194.2|",1631,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102554746 (LOC102554746), mRNA",".",".",".",".",".",".",".",".","pfam03925","SeqA","SeqA protein. The binding of SeqA protein to hemimethylated GATC sequences is important in the negative modulation of chromosomal initiation at oriC, and in the formation of SeqA foci necessary for Escherichia coli chromosome segregation. SeqA tetramers are able to aggregate or multimerize in a reversible, concentration-dependent manner. Apart from its function in the control of DNA replication, SeqA may also be a specific transcription factor.",".",".",".",".","."]
["ENSRNOG00000006726",42,3.533681283,126,8.105635211,0.435953653,-1.197753326,{"v":4.91506e-07,"d":"4.92E-07"},{"v":5.9155e-07,"d":"5.92E-07"},"down","yes","Zfp9","protein_coding","chr4:151638711-151656803:-","gi|189083704|ref|NP_001121107.1|",2385,0,"zinc finger protein 25 [Rattus norvegicus]","gi|219282699|ref|NM_001127635.2|",2284,0,"Rattus norvegicus zinc finger protein 9 (Zfp9), mRNA","P17030",729,0,"Zinc finger protein 25",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006355|regulation of transcription, DNA-templated;",".","GO:0046872|metal ion binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSRNOG00000022499",55,4.627439776,151,9.713896166,0.476373197,-1.069835851,{"v":4.9508e-07,"d":"4.95E-07"},{"v":5.95325e-07,"d":"5.95E-07"},"down","yes","Sgo1","protein_coding","chr9:6672123-6687805:-","gi|672033118|ref|XP_008756343.1|",2656,0,"PREDICTED: shugoshin-like 1 isoform X1 [Rattus norvegicus]","gi|672033117|ref|XM_008758121.1|",3222,0,"PREDICTED: Rattus norvegicus shugoshin-like 1 (S. pombe) (Sgol1), transcript variant X1, mRNA","Q9CXH7",689,0,"Shugoshin 1",".",".",".",".","pfam07558","Shugoshin_N","Shugoshin N-terminal coiled-coil region. The Shugoshin protein is found to have this conserved N-terminal coiled-coil region and a highly conserved C-terminal basic region, family Shugoshin_C pfam07557. Shugoshin is a crucial target of Bub1 kinase function at kinetochores, necessary for both meiotic and mitotic localisation of shugoshin to the kinetochore. Human shugoshin is diffusible and mediates kinetochore-driven formation of kinetochore-microtubules during bipolar spindle assembly. Further, the primary role of shugoshin is to ensure bipolar attachment of kinetochores, and its role in protecting cohesion has co-developed to facilitate this process.","GO:0000070|mitotic sister chromatid segregation;GO:0007059|chromosome segregation;GO:0008608|attachment of spindle microtubules to kinetochore;GO:0010457|centriole-centriole cohesion;GO:0045132|meiotic chromosome segregation;GO:0045143|homologous chromosome segregation;GO:0051177|meiotic sister chromatid cohesion;GO:0051301|cell division;GO:0071962|mitotic sister chromatid cohesion, centromeric;","GO:0000775|chromosome, centromeric region;GO:0000776|kinetochore;GO:0000779|condensed chromosome, centromeric region;GO:0000922|spindle pole;GO:0005654|nucleoplasm;GO:0005813|centrosome;GO:0005829|cytosol;","GO:0019900|kinase binding;","K11580","SGOL1; shugoshin-like 1"]
["ENSRNOG00000039865",37,3.11300494,116,7.462330829,0.417162548,-1.261318455,{"v":4.99967e-07,"d":"5.00E-07"},{"v":6.01069e-07,"d":"6.01E-07"},"down","yes","Vnn3","protein_coding","chr1:21571364-21583626:-","gi|157820363|ref|NP_001102606.1|",2702,0,"vascular non-inflammatory molecule 3 precursor [Rattus norvegicus]","gi|157820362|ref|NM_001109136.1|",1753,0,"Rattus norvegicus vanin 3 (Vnn3), mRNA","Q9QZ25",978,0,"Vascular non-inflammatory molecule 3","PH0642",68.6,{"v":4e-12,"d":"4.00E-12"},"COG0388","pfam00795","CN_hydrolase","Carbon-nitrogen hydrolase. This family contains hydrolases that break carbon-nitrogen bonds. The family includes: Nitrilase EC:3.5.5.1, Aliphatic amidase EC:3.5.1.4, Biotidinase EC:3.5.1.12, Beta-ureidopropionase EC:3.5.1.6. Nitrilase-related proteins generally have a conserved E-K-C catalytic triad, and are multimeric alpha-beta-beta-alpha sandwich proteins.","GO:0015939|pantothenate metabolic process;","GO:0005615|extracellular space;","GO:0017159|pantetheine hydrolase activity;","K08069","VNN; pantetheine hydrolase [EC:3.5.1.92]"]
["ENSRNOG00000019404",10,0.841352686,56,3.602504538,0.2335466,-2.098217652,{"v":5.02773e-07,"d":"5.03E-07"},{"v":6.03909e-07,"d":"6.04E-07"},"down","yes","Hhatl","protein_coding","chr8:121447002-121454001:-","gi|157822045|ref|NP_001100338.1|",2570,0,"protein-cysteine N-palmitoyltransferase HHAT-like protein [Rattus norvegicus]","gi|157822044|ref|NM_001106868.1|",1626,0,"Rattus norvegicus hedgehog acyltransferase-like (Hhatl), mRNA","Q9D1G3",974,0,"Protein-cysteine N-palmitoyltransferase HHAT-like protein","YGL084c",67.4,{"v":6E-11,"d":"6.00E-11"},"COG1696","pfam03062","MBOAT","MBOAT, membrane-bound O-acyltransferase family. The MBOAT (membrane bound O-acyl transferase) family of membrane proteins contains a variety of acyltransferase enzymes. A conserved histidine has been suggested to be the active site residue.","GO:0060262|negative regulation of N-terminal protein palmitoylation;","GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;GO:0048471|perinuclear region of cytoplasm;","GO:0016746|transferase activity, transferring acyl groups;","K24679","HHATL; protein-cysteine N-palmitoyltransferase HHAT-like protein"]
["ENSRNOG00000002471",20,1.682705373,80,5.146435055,0.32696524,-1.612790825,{"v":5.11612e-07,"d":"5.12E-07"},{"v":6.14392e-07,"d":"6.14E-07"},"down","yes","Polq","protein_coding","chr11:63673816-63775878:-","gi|157786800|ref|NP_001099348.1|",12889,0,"DNA polymerase theta [Rattus norvegicus]","gi|157786799|ref|NM_001105878.1|",8524,0,"Rattus norvegicus polymerase (DNA directed), theta (Polq), mRNA","Q8CGS6",4273,0,"DNA polymerase theta","MA3203",222,{"v":1E-58,"d":"1.00E-58"},"COG1204","pfam00476","DNA_pol_A","DNA polymerase family A.","GO:0006261|DNA-dependent DNA replication;GO:0006281|DNA repair;GO:0006284|base-excision repair;GO:0006302|double-strand break repair;GO:0006974|cellular response to DNA damage stimulus;GO:0016446|somatic hypermutation of immunoglobulin genes;GO:0032508|DNA duplex unwinding;GO:0051260|protein homooligomerization;GO:0071897|DNA biosynthetic process;GO:0097681|double-strand break repair via alternative nonhomologous end joining;GO:2000042|negative regulation of double-strand break repair via homologous recombination;","GO:0005654|nucleoplasm;GO:0005794|Golgi apparatus;GO:0005829|cytosol;","GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003887|DNA-directed DNA polymerase activity;GO:0005524|ATP binding;GO:0017116|single-stranded DNA-dependent ATP-dependent DNA helicase activity;GO:0042802|identical protein binding;GO:0051575|5'-deoxyribose-5-phosphate lyase activity;","K02349","POLQ; DNA polymerase theta [EC:2.7.7.7]"]
["ENSRNOG00000028541",25,2.103381716,91,5.854069875,0.359302462,-1.476729276,{"v":5.13516e-07,"d":"5.14E-07"},{"v":6.16406e-07,"d":"6.16E-07"},"down","yes","Btnl2","protein_coding","chr20:4489517-4503341:-","gi|258679494|ref|NP_446267.1|",2618,0,"butyrophilin-like protein 2 [Rattus norvegicus]","gi|258679493|ref|NM_053815.1|",1542,0,"Rattus norvegicus butyrophilin-like 2 (Btnl2), mRNA","Q6MG97",929,0,"Butyrophilin-like protein 2",".",".",".",".","pfam08205","C2-set_2","CD80-like C2-set immunoglobulin domain. These domains belong to the immunoglobulin superfamily.","GO:0001817|regulation of cytokine production;GO:0008150|biological_process;GO:0032743|positive regulation of interleukin-2 production;GO:0042102|positive regulation of T cell proliferation;GO:0050852|T cell receptor signaling pathway;GO:0050860|negative regulation of T cell receptor signaling pathway;","GO:0005575|cellular_component;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0005102|signaling receptor binding;",".","."]
["ENSRNOG00000006802",12,1.009623224,61,3.924156729,0.257284123,-1.958565662,{"v":5.28576e-07,"d":"5.29E-07"},{"v":6.34343e-07,"d":"6.34E-07"},"down","yes","Lrrn1","protein_coding","chr4:140476324-140518620:+","gi|82654226|ref|NP_001032440.1|",3768,0,"leucine-rich repeat neuronal protein 1 precursor [Rattus norvegicus]","gi|672050690|ref|XM_006236985.2|",5674,0,"PREDICTED: Rattus norvegicus leucine rich repeat neuronal 1 (Lrrn1), transcript variant X2, mRNA","Q32Q07",1456,0,"Leucine-rich repeat neuronal protein 1","alr0124_1",86.7,{"v":2E-16,"d":"2.00E-16"},"COG4886","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0051965|positive regulation of synapse assembly;","GO:0005615|extracellular space;GO:0016021|integral component of membrane;GO:0031012|extracellular matrix;",".","K24492","LRRN1_2_3; leucine-rich repeat neuronal protein 1/2/3"]
["ENSRNOG00000002751",26,2.187516985,93,5.982730751,0.365638548,-1.451509918,{"v":5.40819e-07,"d":"5.41E-07"},{"v":6.47632e-07,"d":"6.48E-07"},"down","yes","Zdhhc15","protein_coding","chrX:69574124-69701756:-","gi|84993239|ref|NP_001034190.1|",1725,0,"palmitoyltransferase ZDHHC15 [Rattus norvegicus]","gi|84993238|ref|NM_001039101.1|",2883,0,"Rattus norvegicus zinc finger, DHHC-type containing 15 (Zdhhc15), mRNA","Q2TGJ4",669,0,"Palmitoyltransferase ZDHHC15","ECU04g0260",116,{"v":3e-27,"d":"3.00E-27"},"COG5273","pfam01529","zf-DHHC","DHHC palmitoyltransferase. This family includes the well known DHHC zinc binding domain as well as three of the four conserved transmembrane regions found in this family of palmitoyltransferase enzymes.","GO:0006612|protein targeting to membrane;GO:0016188|synaptic vesicle maturation;GO:0018230|peptidyl-L-cysteine S-palmitoylation;GO:0018345|protein palmitoylation;GO:0045184|establishment of protein localization;GO:0061001|regulation of dendritic spine morphogenesis;GO:0072657|protein localization to membrane;GO:1900006|positive regulation of dendrite development;","GO:0000139|Golgi membrane;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0014069|postsynaptic density;GO:0030173|integral component of Golgi membrane;GO:0098794|postsynapse;","GO:0008270|zinc ion binding;GO:0016409|palmitoyltransferase activity;GO:0019705|protein-cysteine S-myristoyltransferase activity;GO:0019706|protein-cysteine S-palmitoyltransferase activity;","K20028","ZDHHC2_15_20; palmitoyltransferase ZDHHC2/15/20 [EC:2.3.1.225]"]
["ENSRNOG00000016058",26,2.187516985,93,5.982730751,0.365638548,-1.451509918,{"v":5.40819e-07,"d":"5.41E-07"},{"v":6.47632e-07,"d":"6.48E-07"},"down","yes","Kazald1","protein_coding","chr1:243939647-243943059:+","gi|74271919|ref|NP_001028236.1|",1426,0,"kazal-type serine protease inhibitor domain-containing protein 1 precursor [Rattus norvegicus]","gi|74271918|ref|NM_001033064.1|",1622,0,"Rattus norvegicus Kazal-type serine peptidase inhibitor domain 1 (Kazald1), mRNA","Q8BJ66",527,0,"Kazal-type serine protease inhibitor domain-containing protein 1",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0001558|regulation of cell growth;GO:0009966|regulation of signal transduction;GO:0030198|extracellular matrix organization;","GO:0005576|extracellular region;GO:0005614|interstitial matrix;GO:0031012|extracellular matrix;","GO:0005520|insulin-like growth factor binding;","K25568","KAZALD1; Kazal-type serine protease inhibitor domain-containing protein 1"]
["ENSRNOG00000016046",21,1.766840642,82,5.275095931,0.334940002,-1.578025407,{"v":5.59331e-07,"d":"5.59E-07"},{"v":6.68746e-07,"d":"6.69E-07"},"down","yes","Hecw1","protein_coding","chr17:50670954-51080720:+","gi|672081938|ref|XP_008769919.1|",7773,0,"PREDICTED: E3 ubiquitin-protein ligase HECW1 isoform X1 [Rattus norvegicus]","gi|672081937|ref|XM_008771697.1|",5096,0,"PREDICTED: Rattus norvegicus HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 (Hecw1), transcript variant X1, mRNA","Q8K4P8",2876,0,"E3 ubiquitin-protein ligase HECW1","SPBC16E9.11c",384,{"v":9e-114,"d":"9.00E-114"},"COG5021","pfam00632","HECT","HECT-domain (ubiquitin-transferase). The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.","GO:0000209|protein polyubiquitination;GO:0016567|protein ubiquitination;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045732|positive regulation of protein catabolic process;GO:0048814|regulation of dendrite morphogenesis;GO:2000650|negative regulation of sodium ion transmembrane transporter activity;","GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0016874|ligase activity;GO:0061630|ubiquitin protein ligase activity;","K12167","HECW1; E3 ubiquitin-protein ligase HECW1 [EC:2.3.2.26]"]
["ENSRNOG00000046449",22,1.85097591,84,5.403756808,0.342535013,-1.545676629,{"v":6.05441e-07,"d":"6.05E-07"},{"v":7.20082e-07,"d":"7.20E-07"},"down","yes","Npy","protein_coding","chr4:78881264-78888495:+","gi|6981286|ref|NP_036746.1|",412,{"v":3e-48,"d":"3.00E-48"},"pro-neuropeptide Y preproprotein [Rattus norvegicus]","gi|672049719|ref|XM_003749745.3|",525,0,"PREDICTED: Rattus norvegicus pro-neuropeptide Y-like (LOC100912228), mRNA","P07808",163,{"v":1e-49,"d":"1.00E-49"},"Pro-neuropeptide Y",".",".",".",".","pfam00159","Hormone_3","Pancreatic hormone peptide.","GO:0001878|response to yeast;GO:0002865|negative regulation of acute inflammatory response to antigenic stimulus;GO:0007218|neuropeptide signaling pathway;GO:0007268|chemical synaptic transmission;GO:0007568|aging;GO:0007631|feeding behavior;GO:0008217|regulation of blood pressure;GO:0008284|positive regulation of cell proliferation;GO:0008343|adult feeding behavior;GO:0010811|positive regulation of cell-substrate adhesion;GO:0019731|antibacterial humoral response;GO:0019732|antifungal humoral response;GO:0021954|central nervous system neuron development;GO:0021987|cerebral cortex development;GO:0031175|neuron projection development;GO:0031640|killing of cells of other organism;GO:0032100|positive regulation of appetite;GO:0032903|regulation of nerve growth factor production;GO:0042117|monocyte activation;GO:0045087|innate immune response;GO:0045776|negative regulation of blood pressure;GO:0045964|positive regulation of dopamine metabolic process;GO:0048572|short-day photoperiodism;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:0050909|sensory perception of taste;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0090274|positive regulation of somatostatin secretion;GO:0090275|negative regulation of somatostatin secretion;GO:1901215|negative regulation of neuron death;GO:1904000|positive regulation of eating behavior;GO:1904407|positive regulation of nitric oxide metabolic process;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0043005|neuron projection;GO:0043195|terminal bouton;GO:0043204|perikaryon;GO:0048471|perinuclear region of cytoplasm;GO:0098992|neuronal dense core vesicle;","GO:0001664|G protein-coupled receptor binding;GO:0005179|hormone activity;GO:0005184|neuropeptide hormone activity;GO:0031841|neuropeptide Y receptor binding;","K05232","NPY; neuropeptide Y"]
["ENSRNOG00000057645",23,1.935111179,86,5.532417684,0.349776768,-1.515493624,{"v":6.49465e-07,"d":"6.49E-07"},{"v":7.71094e-07,"d":"7.71E-07"},"down","yes","Micb","protein_coding","chr1:78495779-78512827:+","gi|62945292|ref|NP_001017468.1|",1532,0,"MHC class I-like located near the LRC, 2 precursor [Rattus norvegicus]","gi|53850435|dbj|AB114034.1|",543,0,"Rattus norvegicus Mill2 gene for MHC class I-like located near the LRC, 2, exon 4, partial cds, strain:PVG","Q9GL42",119,{"v":7e-29,"d":"7.00E-29"},"Hereditary hemochromatosis protein homolog",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.","GO:0002429|immune response-activating cell surface receptor signaling pathway;GO:0006955|immune response;GO:0006979|response to oxidative stress;GO:0009408|response to heat;GO:0032526|response to retinoic acid;GO:0046629|gamma-delta T cell activation;GO:0050689|negative regulation of defense response to virus by host;","GO:0005615|extracellular space;GO:0009897|external side of plasma membrane;GO:0031225|anchored component of membrane;","GO:0046703|natural killer cell lectin-like receptor binding;",".","."]
["ENSRNOG00000023101",0,0.042067634,26,1.672591393,0.025151172,-5.313230543,{"v":6.79554e-07,"d":"6.80E-07"},{"v":8.05412e-07,"d":"8.05E-07"},"down","yes","AABR07047835.1","protein_coding","chr5:48925362-48927475:+","gi|564348552|ref|XP_006237244.1|",1348,0,"PREDICTED: chondroitin sulfate N-acetylgalactosaminyltransferase 2 isoform X2 [Rattus norvegicus]","gi|672050825|ref|XM_006237182.2|",735,0,"PREDICTED: Rattus norvegicus chondroitin sulfate N-acetylgalactosaminyltransferase 2 (Csgalnact2), transcript variant X2, mRNA","Q8C1F4",507,{"v":3E-176,"d":"3.00E-176"},"Chondroitin sulfate N-acetylgalactosaminyltransferase 2",".",".",".",".","pfam05679","CHGN","Chondroitin N-acetylgalactosaminyltransferase.",".",".",".",".","."]
["ENSRNOG00000033763",14,1.177893761,65,4.181478482,0.28169313,-1.827803716,{"v":7.71109e-07,"d":"7.71E-07"},{"v":9.09963e-07,"d":"9.10E-07"},"down","yes","RGD1307537","protein_coding","chr17:29929780-29966579:-","gi|149045215|gb|EDL98301.1|",1064,{"v":8e-144,"d":"8.00E-144"},"similar to RIKEN cDNA 4933417A18 [Rattus norvegicus]","gi|50927387|gb|BC079269.1|",695,0,"Rattus norvegicus similar to RIKEN cDNA 4933417A18, mRNA (cDNA clone MGC:94380 IMAGE:7133712), complete cds","Q6AXY2",413,{"v":8e-145,"d":"8.00E-145"},"Uncharacterized protein C6orf201 homolog",".",".",".",".","pfam15023","DUF4523","Protein of unknown function (DUF4523). This family of proteins is functionally uncharacterized. This family of proteins is found in mammals.",".",".","GO:0003676|nucleic acid binding;",".","."]
["ENSRNOG00000000840",15,1.26202903,67,4.310139358,0.292804693,-1.77198942,{"v":9.01277e-07,"d":"9.01E-07"},{"v":1.05852E-6,"d":"1.06E-06"},"down","yes","Atp6v1g2","protein_coding","chr20:3587686-3590481:-","gi|47059104|ref|NP_997655.1|",303,{"v":3e-29,"d":"3.00E-29"},"V-type proton ATPase subunit G 2 [Rattus norvegicus]","gi|110350025|gb|AC130591.5|",1660,0,"Rattus norvegicus BAC CH230-312A21 () complete sequence","Q5WR09",117,{"v":2e-29,"d":"2.00E-29"},"V-type proton ATPase subunit G 1",".",".",".",".","pfam03179","V-ATPase_G","Vacuolar (H+)-ATPase G subunit. This family represents the eukaryotic vacuolar (H+)-ATPase (V-ATPase) G subunit. V-ATPases generate an acidic environment in several intracellular compartments. Correspondingly, they are found as membrane-attached proteins in several organelles. They are also found in the plasma membranes of some specialized cells. V-ATPases consist of peripheral (V1) and membrane integral (V0) heteromultimeric complexes. The G subunit is part of the V1 subunit, but is also thought to be strongly attached to the V0 complex. It may be involved in the coupling of ATP degradation to H+ translocation.","GO:1902600|proton transmembrane transport;","GO:0016471|vacuolar proton-transporting V-type ATPase complex;GO:0030285|integral component of synaptic vesicle membrane;","GO:0008553|proton-exporting ATPase activity, phosphorylative mechanism;GO:0016887|ATPase activity;GO:0046961|proton-transporting ATPase activity, rotational mechanism;","K02152","ATPeV1G, ATP6G; V-type H+-transporting ATPase subunit G"]
["ENSRNOG00000010545",34,2.860599134,108,6.947687324,0.411734006,-1.280215486,{"v":9.27277E-7,"d":"9.27E-07"},{"v":1.08812e-06,"d":"1.09E-06"},"down","yes","Mrap2","protein_coding","chr8:88088272-88143886:+","gi|157817506|ref|NP_001102244.1|",1108,{"v":2e-148,"d":"2.00E-148"},"melanocortin-2 receptor accessory protein 2 [Rattus norvegicus]","gi|157817505|ref|NM_001108774.1|",1313,0,"Rattus norvegicus melanocortin 2 receptor accessory protein 2 (Mrap2), mRNA","D3Z1Q2",413,{"v":9E-143,"d":"9.00E-143"},"Melanocortin-2 receptor accessory protein 2",".",".",".",".","pfam15183","MRAP","Melanocortin-2 receptor accessory protein family. This family is thought to be involved in cell trafficking. It is required for MC2R expression in certain cell types, suggesting that it is involved in the processing, trafficking or function of MC2R. MRAP may be involved in the intracellular trafficking pathways in adipocyte cells. This family of proteins is found in eukaryotes. Proteins in this family are typically between 47 and 205 amino acids in length.","GO:0006112|energy reserve metabolic process;GO:0007631|feeding behavior;GO:0072659|protein localization to plasma membrane;GO:0097009|energy homeostasis;GO:0106070|regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0106071|positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0106072|negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:1903077|negative regulation of protein localization to plasma membrane;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0030545|receptor regulator activity;GO:0031780|corticotropin hormone receptor binding;GO:0031781|type 3 melanocortin receptor binding;GO:0031782|type 4 melanocortin receptor binding;GO:0031783|type 5 melanocortin receptor binding;GO:0042802|identical protein binding;GO:0070996|type 1 melanocortin receptor binding;",".","."]
["ENSRNOG00000011451",36,3.028869671,112,7.205009077,0.42038388,-1.250220746,{"v":9.3488e-07,"d":"9.35E-07"},{"v":1.09657E-6,"d":"1.10E-06"},"down","yes","Lrp3","protein_coding","chr1:87844868-87859110:-","gi|16758310|ref|NP_445993.1|",3539,0,"low-density lipoprotein receptor-related protein 3 precursor [Rattus norvegicus]","gi|672035899|ref|XM_008759202.1|",3452,0,"PREDICTED: Rattus norvegicus low density lipoprotein receptor-related protein 3 (Lrp3), transcript variant X6, mRNA","O88204",1367,0,"Low-density lipoprotein receptor-related protein 3",".",".",".",".","pfam00431","CUB","CUB domain.","GO:0006897|endocytosis;GO:0008150|biological_process;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0045599|negative regulation of fat cell differentiation;GO:0045669|positive regulation of osteoblast differentiation;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0005905|clathrin-coated pit;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;","K20050","LRP3_10_12; low-density lipoprotein receptor-related protein 3/10/12"]
["ENSRNOG00000068365",25,2.103381716,89,5.725408998,0.367376674,-1.444668066,{"v":1.03449e-06,"d":"1.03E-06"},{"v":1.20949E-6,"d":"1.21E-06"},"down","yes","ENSRNOG00000068365","lncRNA","chr4:81647412-81648449:+",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","pfam04082","Fungal_trans","Fungal specific transcription factor domain.",".",".",".",".","."]
["ENSRNOG00000016110",28,2.355787522,95,6.111391628,0.385474809,-1.375291512,{"v":1.15806e-06,"d":"1.16E-06"},{"v":1.34847e-06,"d":"1.35E-06"},"down","yes","Kcnk12","protein_coding","chr6:6739991-6790661:+","gi|562868708|ref|XP_006162413.1|",1538,0,"PREDICTED: potassium channel subfamily K member 12 [Tupaia chinensis]","gi|67972619|gb|AC124316.32|",1553,0,"Mus musculus chromosome 17, clone RP24-222O13, complete sequence","Q9ERS1",555,0,"Potassium channel subfamily K member 12",".",".",".",".","pfam07885","Ion_trans_2","Ion channel. This family includes the two membrane helix type ion channels found in bacteria.","GO:0030322|stabilization of membrane potential;GO:0034765|regulation of ion transmembrane transport;GO:0071805|potassium ion transmembrane transport;","GO:0005887|integral component of plasma membrane;","GO:0005244|voltage-gated ion channel activity;GO:0022841|potassium ion leak channel activity;","K04921","KCNK12, K2P12.1; potassium channel subfamily K member 12"]
["ENSRNOG00000009863",17,1.430299567,71,4.567461111,0.313149807,-1.675075104,{"v":1.16821E-6,"d":"1.17E-06"},{"v":1.35971e-06,"d":"1.36E-06"},"down","yes","Prrt3","protein_coding","chr4:146641173-146650317:-","gi|827475627|ref|NP_001296392.1|",3176,0,"proline-rich transmembrane protein 3 precursor [Rattus norvegicus]","gi|827475626|ref|NM_001309463.1|",4342,0,"Rattus norvegicus proline-rich transmembrane protein 3 (Prrt3), mRNA","Q6PE13",1059,0,"Proline-rich transmembrane protein 3",".",".",".",".","pfam05518","Totivirus_coat","Totivirus coat protein.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000068241",10,0.841352686,54,3.473843662,0.242196474,-2.045750233,{"v":1.20237e-06,"d":"1.20E-06"},{"v":1.39708E-6,"d":"1.40E-06"},"down","yes","ENSRNOG00000068241","protein_coding","chr7:7759282-7780082:-","gi|251823941|ref|NP_001156535.1|",1659,0,"zinc finger protein 878 [Rattus norvegicus]","gi|672057921|ref|XM_008765141.1|",1164,0,"PREDICTED: Rattus norvegicus zinc finger protein 709-like (LOC100909526), transcript variant X2, mRNA","E9QAG8",407,{"v":2e-127,"d":"2.00E-127"},"Zinc finger protein 431",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000066849",5,0.420676343,40,2.573217527,0.16348262,-2.612790825,{"v":1.31473e-06,"d":"1.31E-06"},{"v":1.52341E-6,"d":"1.52E-06"},"down","yes","RGD1564748","protein_coding","chrX:4755173-4762467:+","gi|672032027|ref|XP_008756584.1|",7400,0,"PREDICTED: collagen alpha-1(III) chain-like isoform X11 [Rattus norvegicus]","gi|672032009|ref|XM_008758354.1|",3616,0,"PREDICTED: Rattus norvegicus similar to Mortality factor 4-like protein 2 (MORF-related gene X protein) (RGD1564748), transcript variant X2, mRNA","Q4R578",256,{"v":2e-74,"d":"2.00E-74"},"Mortality factor 4-like protein 2",".",".",".",".","pfam05712","MRG","MRG. This family consists of three different eukaryotic proteins (mortality factor 4 (MORF4/MRG15), male-specific lethal 3(MSL-3) and ESA1-associated factor 3(EAF3)). It is thought that the MRG family is involved in transcriptional regulation via histone acetylation. It contains 2 chromo domains and a leucine zipper motif.",".",".",".",".","."]
["ENSRNOG00000042944",58,4.879845581,153,9.842557042,0.495790429,-1.012197673,{"v":1.31957e-06,"d":"1.32E-06"},{"v":1.52805e-06,"d":"1.53E-06"},"down","yes","Cenpw","protein_coding","chr1:27525324-27530464:+","gi|350540004|ref|NP_001233248.1|",431,{"v":8e-48,"d":"8.00E-48"},"centromere protein W [Rattus norvegicus]","gi|350540003|ref|NM_001246319.1|",1601,0,"Rattus norvegicus centromere protein W (Cenpw), mRNA","A1L1L1",170,{"v":3E-49,"d":"3.00E-49"},"Centromere protein W",".",".",".",".","pfam15510","CENP-W","Centromere kinetochore component W. CENP-W is a family of vertebral kinetochore proteins that associates directly with CENP-T. CENP-W members are histone-fold proteins. The histone fold region is critical for binding to centromeric DNA. Importantly, the CENP-T-W complex does not directly associate with CENP-A, but with histone H3 in the centromere region. CENP-T and -W form a hetero-tetramer with CENP-S and -X and bind to a ~100 bp region of nucleosome-free DNA forming a nucleosome-like structure. The DNA-CENP-T-W-S-X complex is likely to be associated with histone H3-containing nucleosomes rather than with CENP-nucleosomes.","GO:0000278|mitotic cell cycle;GO:0007059|chromosome segregation;GO:0051276|chromosome organization;GO:0051301|cell division;GO:0051382|kinetochore assembly;","GO:0000775|chromosome, centromeric region;GO:0000776|kinetochore;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0016363|nuclear matrix;","GO:0003677|DNA binding;GO:0046982|protein heterodimerization activity;",".","."]
["ENSRNOG00000022537",57,4.795710313,151,9.713896166,0.493695859,-1.01830555,{"v":1.37257E-6,"d":"1.37E-06"},{"v":1.58705e-06,"d":"1.59E-06"},"down","yes","E2f8","protein_coding","chr1:98565717-98584098:-","gi|109462000|ref|XP_001080259.1|",4545,0,"PREDICTED: transcription factor E2F8 isoform X1 [Rattus norvegicus]","gi|672013602|ref|XM_001080259.5|",5122,0,"PREDICTED: Rattus norvegicus E2F transcription factor 8 (E2f8), transcript variant X1, mRNA","F1LMN3",1680,0,"Transcription factor E2F8",".",".",".",".","pfam02319","E2F_TDP","E2F/DP family winged-helix DNA-binding domain. This family contains the transcription factor E2F and its dimerization partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001890|placenta development;GO:0002040|sprouting angiogenesis;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008283|cell proliferation;GO:0032466|negative regulation of cytokinesis;GO:0032877|positive regulation of DNA endoreduplication;GO:0033301|cell cycle comprising mitosis without cytokinesis;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0060707|trophoblast giant cell differentiation;GO:0060718|chorionic trophoblast cell differentiation;GO:0070365|hepatocyte differentiation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005730|nucleolus;GO:0005829|cytosol;GO:0090575|RNA polymerase II transcription factor complex;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987|proximal promoter sequence-specific DNA binding;GO:0001217|bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0042802|identical protein binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09391","E2F7_8; transcription factor E2F7/8"]
["ENSRNOG00000063551",2,0.168270537,30,1.929913146,0.087190731,-3.519681421,{"v":1.41542E-6,"d":"1.42E-06"},{"v":1.63347e-06,"d":"1.63E-06"},"down","yes","ENSRNOG00000063551","lncRNA","chr5:70168476-70171183:+","gi|37361874|gb|AAQ91050.1|",125,{"v":2e-11,"d":"2.00E-11"},"LRRGT00094 [Rattus norvegicus]","gi|49457876|gb|AC129700.8|",1588,0,"Rattus norvegicus 4 BAC CH230-10L17 (Children's Hospital Oakland Research Institute) complete sequence","P51517",53.9,7e-06,"Gag-Pro-Pol polyprotein",".",".",".",".","pfam14828","Amnionless","Amnionless. The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.",".",".",".",".","."]
["ENSRNOG00000047848",13,1.093758492,61,3.924156729,0.278724467,-1.843088445,{"v":1.46967e-06,"d":"1.47E-06"},{"v":1.69285E-6,"d":"1.69E-06"},"down","yes","Cbr1","pseudogene","chr11:32908950-32911393:+","gi|564376239|ref|XP_006248171.1|",1585,0,"PREDICTED: carbonyl reductase [NADPH] 1 [Rattus norvegicus]","gi|672070752|ref|XM_006248109.2|",1023,0,"PREDICTED: Rattus norvegicus carbonyl reductase [NADPH] 1-like (LOC102556347), mRNA","P47727",524,0,"Carbonyl reductase [NADPH] 1","all0352",126,{"v":6e-33,"d":"6.00E-33"},"COG1028","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.","GO:0001542|ovulation from ovarian follicle;GO:0006706|steroid catabolic process;GO:0006805|xenobiotic metabolic process;GO:0030855|epithelial cell differentiation;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0032570|response to progesterone;GO:0033574|response to testosterone;GO:0034698|response to gonadotropin;GO:0042373|vitamin K metabolic process;GO:0042376|phylloquinone catabolic process;GO:1905344|prostaglandin catabolic process;GO:2000379|positive regulation of reactive oxygen species metabolic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005902|microvillus;GO:0035003|subapical complex;GO:0043231|intracellular membrane-bounded organelle;","GO:0004090|carbonyl reductase (NADPH) activity;GO:0005515|protein binding;GO:0016491|oxidoreductase activity;GO:0016655|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0047020|15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity;GO:0047021|15-hydroxyprostaglandin dehydrogenase (NADP+) activity;GO:0050221|prostaglandin-E2 9-reductase activity;","K00079","CBR1; carbonyl reductase 1 [EC:1.1.1.184 1.1.1.189 1.1.1.197]"]
["ENSRNOG00000047459",20,1.682705373,77,4.95344374,0.339704145,-1.557649271,{"v":1.55463e-06,"d":"1.55E-06"},{"v":1.78845E-6,"d":"1.79E-06"},"down","yes","H1f4","protein_coding","chr17:41486560-41487403:+","gi|281345275|gb|EFB20859.1|",316,{"v":4e-32,"d":"4.00E-32"},"hypothetical protein PANDA_018553, partial [Ailuropoda melanoleuca]","gi|287651|emb|X67320.1|",838,0,"R.norvegicus genes for H1d-histone and H2B-histone","P15865",127,{"v":2e-33,"d":"2.00E-33"},"Histone H1.4",".",".",".",".","pfam00538","Linker_histone","linker histone H1 and H5 family. Linker histone H1 is an essential component of chromatin structure. H1 links nucleosomes into higher order structures Histone H1 is replaced by histone H5 in some cell types.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006334|nucleosome assembly;GO:0006357|regulation of transcription by RNA polymerase II;GO:0016584|nucleosome positioning;GO:0030261|chromosome condensation;GO:0080182|histone H3-K4 trimethylation;GO:0098532|histone H3-K27 trimethylation;","GO:0000785|chromatin;GO:0000786|nucleosome;GO:0000792|heterochromatin;GO:0005634|nucleus;","GO:0000166|nucleotide binding;GO:0003677|DNA binding;GO:0003690|double-stranded DNA binding;GO:0005509|calcium ion binding;GO:0005524|ATP binding;GO:0005525|GTP binding;GO:0016208|AMP binding;GO:0031490|chromatin DNA binding;GO:0032564|dATP binding;GO:0043531|ADP binding;","K11275","H1_5; histone H1/5"]
["ENSRNOG00000059837",42,3.533681283,122,7.848313459,0.450247216,-1.15121074,{"v":1.6241E-6,"d":"1.62E-06"},{"v":1.86522e-06,"d":"1.87E-06"},"down","yes","Cdkn2a","protein_coding","chr5:103984949-104003149:-","gi|13928746|ref|NP_113738.1|",574,{"v":2E-70,"d":"2.00E-70"},"cyclin-dependent kinase inhibitor 2A [Rattus norvegicus]","gi|18644699|gb|AF474974.1|",701,0,"Rattus norvegicus strain ACI/SegHsd cyclin-dependent kinase inhibitor 2a p19Arf (Cdkn2a) mRNA, complete cds","Q9R0Z3",225,{"v":6e-72,"d":"6.00E-72"},"Cyclin-dependent kinase inhibitor 2A",".",".",".",".","pfam07392","P19Arf_N","Cyclin-dependent kinase inhibitor 2a p19Arf N-terminus. This family represents the N-terminus (approximately 50 residues) of cyclin-dependent kinase inhibitor 2a p19Arf, which seems to be restricted to mammals. This is a tumor-suppressor protein that has been shown to inhibit the growth of human tumor cells lacking functional p53 by inducing a transient G2 arrest and subsequently apoptosis.","GO:0000079|regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0000082|G1/S transition of mitotic cell cycle;GO:0000209|protein polyubiquitination;GO:0000422|autophagy of mitochondrion;GO:0001953|negative regulation of cell-matrix adhesion;GO:0006364|rRNA processing;GO:0006469|negative regulation of protein kinase activity;GO:0006915|apoptotic process;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007265|Ras protein signal transduction;GO:0007568|aging;GO:0007569|cell aging;GO:0008285|negative regulation of cell proliferation;GO:0008544|epidermis development;GO:0008637|apoptotic mitochondrial changes;GO:0009303|rRNA transcription;GO:0009410|response to xenobiotic stimulus;GO:0009651|response to salt stress;GO:0010033|response to organic substance;GO:0010243|response to organonitrogen compound;GO:0010389|regulation of G2/M transition of mitotic cell cycle;GO:0010468|regulation of gene expression;GO:0010628|positive regulation of gene expression;GO:0014070|response to organic cyclic compound;GO:0021549|cerebellum development;GO:0022008|neurogenesis;GO:0030308|negative regulation of cell growth;GO:0030889|negative regulation of B cell proliferation;GO:0031647|regulation of protein stability;GO:0031648|protein destabilization;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0032091|negative regulation of protein binding;GO:0033088|negative regulation of immature T cell proliferation in thymus;GO:0033235|positive regulation of protein sumoylation;GO:0033600|negative regulation of mammary gland epithelial cell proliferation;GO:0034393|positive regulation of smooth muscle cell apoptotic process;GO:0035019|somatic stem cell population maintenance;GO:0042326|negative regulation of phosphorylation;GO:0042593|glucose homeostasis;GO:0043065|positive regulation of apoptotic process;GO:0043517|positive regulation of DNA damage response, signal transduction by p53 class mediator;GO:0045736|negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045786|negative regulation of cell cycle;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046822|regulation of nucleocytoplasmic transport;GO:0046825|regulation of protein export from nucleus;GO:0048103|somatic stem cell division;GO:0050821|protein stabilization;GO:0051090|regulation of DNA-binding transcription factor activity;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051444|negative regulation of ubiquitin-protein transferase activity;GO:0051726|regulation of cell cycle;GO:0051882|mitochondrial depolarization;GO:0060058|positive regulation of apoptotic process involved in mammary gland involution;GO:0061771|response to caloric restriction;GO:0070301|cellular response to hydrogen peroxide;GO:0070534|protein K63-linked ubiquitination;GO:0070542|response to fatty acid;GO:0071333|cellular response to glucose stimulus;GO:0090398|cellular senescence;GO:0090399|replicative senescence;GO:1900182|positive regulation of protein localization to nucleus;GO:1901798|positive regulation of signal transduction by p53 class mediator;GO:1902510|regulation of apoptotic DNA fragmentation;GO:1903051|negative regulation of proteolysis involved in cellular protein catabolic process;GO:1903214|regulation of protein targeting to mitochondrion;GO:1904667|negative regulation of ubiquitin protein ligase activity;GO:1990000|amyloid fibril formation;GO:2000059|negative regulation of ubiquitin-dependent protein catabolic process;GO:2000111|positive regulation of macrophage apoptotic process;GO:2000346|negative regulation of hepatocyte proliferation;GO:2000435|negative regulation of protein neddylation;GO:2000774|positive regulation of cellular senescence;","GO:0001652|granular component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0016604|nuclear body;GO:0032991|protein-containing complex;GO:0035985|senescence-associated heterochromatin focus;","GO:0002039|p53 binding;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0004861|cyclin-dependent protein serine/threonine kinase inhibitor activity;GO:0019789|SUMO transferase activity;GO:0019901|protein kinase binding;GO:0047485|protein N-terminus binding;GO:0051059|NF-kappaB binding;GO:0055105|ubiquitin-protein transferase inhibitor activity;GO:0097371|MDM2/MDM4 family protein binding;GO:0097718|disordered domain specific binding;GO:1990948|ubiquitin ligase inhibitor activity;","K06621","CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A"]
["ENSRNOG00000010696",8,0.673082149,48,3.087861033,0.217976827,-2.197753326,{"v":1.66906E-6,"d":"1.67E-06"},{"v":1.91361E-6,"d":"1.91E-06"},"down","yes","Neil2","protein_coding","chr15:37445381-37454863:-","gi|157822593|ref|NP_001100740.1|",1675,0,"endonuclease 8-like 2 [Rattus norvegicus]","gi|157822592|ref|NM_001107270.1|",1042,0,"Rattus norvegicus nei-like DNA glycosylase 2 (Neil2), mRNA","Q6R2P8",583,0,"Endonuclease 8-like 2",".",".",".",".","pfam06831","H2TH","Formamidopyrimidine-DNA glycosylase H2TH domain. Formamidopyrimidine-DNA glycosylase (Fpg) is a DNA repair enzyme that excises oxidized purines from damaged DNA. This family is the central domain containing the DNA-binding helix-two turn-helix domain.","GO:0006284|base-excision repair;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0015630|microtubule cytoskeleton;GO:0043231|intracellular membrane-bounded organelle;GO:0072686|mitotic spindle;","GO:0003684|damaged DNA binding;GO:0003906|DNA-(apurinic or apyrimidinic site) endonuclease activity;GO:0008017|microtubule binding;GO:0008270|zinc ion binding;GO:0019104|DNA N-glycosylase activity;GO:0140078|class I DNA-(apurinic or apyrimidinic site) endonuclease activity;","K10568","NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]"]
["ENSRNOG00000039856",39,3.281275477,116,7.462330829,0.439711875,-1.185369602,{"v":1.69926e-06,"d":"1.70E-06"},{"v":1.94616e-06,"d":"1.95E-06"},"down","yes","Lrrc73","protein_coding","chr9:14726158-14729158:-","gi|66730525|ref|NP_001019531.1|",1419,0,"leucine-rich repeat-containing protein 73 [Rattus norvegicus]","gi|119310198|ref|NM_001024360.2|",1298,0,"Rattus norvegicus leucine rich repeat containing 73 (Lrrc73), mRNA",".",".",".",".",".",".",".",".","pfam15143","DUF4575","Domain of unknown function (DUF4575). This family of uncharacterized proteins is found in eukaryotes.",".",".",".",".","."]
["ENSRNOG00000017821",23,1.935111179,83,5.339426369,0.362419302,-1.464268301,{"v":1.8865e-06,"d":"1.89E-06"},{"v":2.15159E-6,"d":"2.15E-06"},"down","yes","Agxt2","protein_coding","chr2:59336283-59377926:+","gi|13929196|ref|NP_114023.1|",2781,0,"alanine--glyoxylate aminotransferase 2, mitochondrial [Rattus norvegicus]","gi|1944135|dbj|AB002584.1|",2146,0,"Rattus norvegicus mRNA for beta-alanine-pyruvate aminotransferase, complete cds","Q64565",1075,0,"Alanine--glyoxylate aminotransferase 2, mitochondrial","BMEII0348",301,{"v":6e-93,"d":"6.00E-93"},"COG0160","pfam00202","Aminotran_3","Aminotransferase class-III.","GO:0009436|glyoxylate catabolic process;GO:0019265|glycine biosynthetic process, by transamination of glyoxylate;GO:0019481|L-alanine catabolic process, by transamination;GO:0045429|positive regulation of nitric oxide biosynthetic process;","GO:0005739|mitochondrion;GO:0005759|mitochondrial matrix;","GO:0008453|alanine-glyoxylate transaminase activity;GO:0016223|beta-alanine-pyruvate transaminase activity;GO:0030170|pyridoxal phosphate binding;GO:0047305|(R)-3-amino-2-methylpropionate-pyruvate transaminase activity;","K00827","AGXT2; alanine-glyoxylate transaminase / (R)-3-amino-2-methylpropionate-pyruvate transaminase [EC:2.6.1.44 2.6.1.40]"]
["ENSRNOG00000018039",0,0.042067634,24,1.543930516,0.027247103,-5.197753326,{"v":1.90836E-6,"d":"1.91E-06"},{"v":2.17561e-06,"d":"2.18E-06"},"down","yes","Sncb","protein_coding","chr17:9846802-9855012:+","gi|970705124|ref|XP_015090439.1|",475,{"v":1E-53,"d":"1.00E-53"},"PREDICTED: beta-synuclein [Vicugna pacos]","gi|672081072|ref|XM_006253594.2|",1114,0,"PREDICTED: Rattus norvegicus synuclein, beta (Sncb), transcript variant X1, mRNA","P33567",181,{"v":3e-53,"d":"3.00E-53"},"Beta-synuclein",".",".",".",".","pfam01387","Synuclein","Synuclein. There are three types of synucleins in humans, these are called alpha, beta and gamma. Alpha synuclein has been found mutated in families with autosomal dominant Parkinson's disease. A peptide of alpha synuclein has also been found in amyloid plaques in Alzheimer's patients.","GO:0007268|chemical synaptic transmission;GO:0042417|dopamine metabolic process;GO:0043524|negative regulation of neuron apoptotic process;GO:0048488|synaptic vesicle endocytosis;GO:0050808|synapse organization;GO:1901214|regulation of neuron death;","GO:0005737|cytoplasm;GO:0016234|inclusion body;GO:0030426|growth cone;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0043679|axon terminus;GO:0045202|synapse;GO:0098793|presynapse;GO:0099523|presynaptic cytosol;","GO:0005509|calcium ion binding;GO:0043014|alpha-tubulin binding;GO:0046914|transition metal ion binding;GO:0048487|beta-tubulin binding;GO:1903136|cuprous ion binding;","K24201","SNCB; beta-synuclein"]
["ENSRNOG00000003881",54,4.543304507,144,9.263583099,0.49044786,-1.027828325,{"v":2.01474e-06,"d":"2.01E-06"},{"v":2.29161e-06,"d":"2.29E-06"},"down","yes","Nit1","protein_coding","chr13:83765941-83773332:-","gi|128485833|ref|NP_872609.2|",1605,0,"nitrilase homolog 1 isoform a [Rattus norvegicus]","gi|128485843|ref|NM_001082580.1|",1256,0,"Rattus norvegicus nitrilase 1 (Nit1), transcript variant 2, mRNA","Q7TQ94",622,0,"Deaminated glutathione amidase","SPBC651.02",228,{"v":2e-68,"d":"2.00E-68"},"COG0388","pfam00795","CN_hydrolase","Carbon-nitrogen hydrolase. This family contains hydrolases that break carbon-nitrogen bonds. The family includes: Nitrilase EC:3.5.5.1, Aliphatic amidase EC:3.5.1.4, Biotidinase EC:3.5.1.12, Beta-ureidopropionase EC:3.5.1.6. Nitrilase-related proteins generally have a conserved E-K-C catalytic triad, and are multimeric alpha-beta-beta-alpha sandwich proteins.","GO:0043605|cellular amide catabolic process;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;","GO:0110050|deaminated glutathione amidase activity;","K11206","NIT1, ybeM; deaminated glutathione amidase [EC:3.5.1.128]"]
["ENSRNOG00000008423",19,1.598570104,74,4.760452426,0.335802138,-1.574316677,{"v":2.07242E-6,"d":"2.07E-06"},{"v":2.35279e-06,"d":"2.35E-06"},"down","yes","Gpr22","protein_coding","chr6:48310505-48317486:-","gi|26339128|dbj|BAC33235.1|",2268,0,"unnamed protein product [Mus musculus]","gi|157818248|ref|NM_001106722.1|",4531,0,"Rattus norvegicus G protein-coupled receptor 22 (Gpr22), mRNA","Q8BZL4",769,0,"Probable G-protein coupled receptor 22",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0030030|cell projection organization;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0042277|peptide binding;","K04319","GPR22; G protein-coupled receptor 22"]
["ENSRNOG00000006110",4,0.336541075,36,2.315895775,0.145317884,-2.782715827,{"v":2.0757e-06,"d":"2.08E-06"},{"v":2.35581e-06,"d":"2.36E-06"},"down","yes","Jph1","protein_coding","chr5:2030281-2125284:+","gi|148682412|gb|EDL14359.1|",2958,0,"junctophilin 1, partial [Mus musculus]","gi|157820160|ref|NM_001106630.1|",2461,0,"Rattus norvegicus junctophilin 1 (Jph1), mRNA","Q9ET80",1094,0,"Junctophilin-1",".",".",".",".","pfam02493","MORN","MORN repeat. The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22).  #=GF CC   A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesised to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.","GO:0007517|muscle organ development;","GO:0005654|nucleoplasm;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0014701|junctional sarcoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0016529|sarcoplasmic reticulum;GO:0030018|Z disc;GO:0030314|junctional membrane complex;","GO:0008307|structural constituent of muscle;","K19530","JPH; junctophilin"]
["ENSRNOG00000049034",53,4.459169238,142,9.134922222,0.488145288,-1.03461749,{"v":2.09116e-06,"d":"2.09E-06"},{"v":2.37258e-06,"d":"2.37E-06"},"down","yes","Ptrh1","protein_coding","chr3:16064880-16070648:+","gi|564301379|ref|XP_003753746.2|",696,{"v":1E-100,"d":"1.00E-100"},"PREDICTED: probable peptidyl-tRNA hydrolase isoform X1 [Rattus norvegicus]","gi|672016603|ref|XM_003753698.3|",492,0,"PREDICTED: Rattus norvegicus peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae) (Ptrh1), transcript variant X1, mRNA","Q8BW00",241,{"v":2E-92,"d":"2.00E-92"},"Probable peptidyl-tRNA hydrolase","BH0068",66.6,{"v":2E-14,"d":"2.00E-14"},"COG0193","pfam01195","Pept_tRNA_hydro","Peptidyl-tRNA hydrolase.",".",".","GO:0004045|aminoacyl-tRNA hydrolase activity;","K01056","PTH1, pth, spoVC; peptidyl-tRNA hydrolase, PTH1 family [EC:3.1.1.29]"]
["ENSRNOG00000055499",5,0.420676343,39,2.508887089,0.167674482,-2.576264949,{"v":2.13938e-06,"d":"2.14E-06"},{"v":2.42376e-06,"d":"2.42E-06"},"down","yes","Grid1","protein_coding","chr16:10138925-10885808:+","gi|13259380|ref|NP_077354.1|",5250,0,"glutamate receptor ionotropic, delta-1 precursor [Rattus norvegicus]","gi|13259379|ref|NM_024378.1|",3323,0,"Rattus norvegicus glutamate ionotropic receptor delta type subunit 1 (Grid1), mRNA","Q62640",2027,0,"Glutamate receptor ionotropic, delta-1","alr3187_1",59.3,1E-8,"COG0834","pfam00060","Lig_chan","Ligand-gated ion channel. This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.","GO:0034220|ion transmembrane transport;GO:0035176|social behavior;GO:0035235|ionotropic glutamate receptor signaling pathway;GO:0035249|synaptic transmission, glutamatergic;GO:0050804|modulation of chemical synaptic transmission;GO:0060078|regulation of postsynaptic membrane potential;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0045211|postsynaptic membrane;GO:0098978|glutamatergic synapse;GO:0099061|integral component of postsynaptic density membrane;","GO:0004970|ionotropic glutamate receptor activity;GO:0008066|glutamate receptor activity;GO:0015276|ligand-gated ion channel activity;GO:0038023|signaling receptor activity;GO:0042802|identical protein binding;GO:1904315|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K05206","GRID1; glutamate receptor delta-1 subunit"]
["ENSRNOG00000061358",5,0.420676343,39,2.508887089,0.167674482,-2.576264949,{"v":2.13938e-06,"d":"2.14E-06"},{"v":2.42376e-06,"d":"2.42E-06"},"down","yes","AC129365.1","protein_coding","chr2:141551434-141554016:+","gi|274321177|ref|NP_387500.1|",3531,0,"DNA replication licensing factor MCM4 [Rattus norvegicus]","gi|672071696|ref|XR_358444.2|",2005,0,"PREDICTED: Rattus norvegicus minichromosome maintenance complex component 4 (Mcm4), transcript variant X2, misc_RNA","P49717",1340,0,"DNA replication licensing factor MCM4","YPR019w",558,0,"COG1241","pfam00493","MCM","MCM2/3/5 family.",".",".",".",".","."]
["ENSRNOG00000070944",5,0.420676343,39,2.508887089,0.167674482,-2.576264949,{"v":2.13938e-06,"d":"2.14E-06"},{"v":2.42376e-06,"d":"2.42E-06"},"down","yes","ENSRNOG00000070944","lncRNA","chr9:64452865-64456985:+",".",".",".",".","gi|672065207|ref|XM_006245034.2|",4121,0,"PREDICTED: Rattus norvegicus INO80 complex subunit D (Ino80d), transcript variant X9, mRNA",".",".",".",".",".",".",".",".","pfam06151","Trehalose_recp","Trehalose receptor. In Drosophila, taste is perceived by gustatory neurons located in sensilla distributed on several different appendages throughout the body of the animal. This family represents the taste receptor sensitive to trehalose.",".",".",".",".","."]
["ENSRNOG00000064638",42,3.533681283,121,7.78398302,0.453968267,-1.13933664,{"v":2.1786e-06,"d":"2.18E-06"},{"v":2.46562e-06,"d":"2.47E-06"},"down","yes","Hdhd3","protein_coding","chr5:75946013-75955266:-","gi|157824168|ref|NP_001102981.1|",1223,{"v":3e-150,"d":"3.00E-150"},"haloacid dehalogenase-like hydrolase domain-containing protein 3 [Rattus norvegicus]","gi|154354993|ref|NM_022261.2|",1330,0,"Rattus norvegicus B-box and SPRY domain containing (Bspry), mRNA","Q9CYW4",436,{"v":1e-137,"d":"1.00E-137"},"Haloacid dehalogenase-like hydrolase domain-containing protein 3","alr4095",116,{"v":3e-27,"d":"3.00E-27"},"COG1011","pfam13419","HAD_2","Haloacid dehalogenase-like hydrolase.",".",".",".",".","."]
["ENSRNOG00000050207",11,0.925487955,55,3.5381741,0.261572192,-1.93471892,{"v":2.31162e-06,"d":"2.31E-06"},{"v":2.60481e-06,"d":"2.60E-06"},"down","yes","Utf1","protein_coding","chr1:194740339-194741465:+","gi|149061439|gb|EDM11862.1|",1400,0,"rCG47962 [Rattus norvegicus]","gi|196259784|ref|NM_001131032.1|",1011,0,"Rattus norvegicus undifferentiated embryonic cell transcription factor 1 (Utf1), mRNA","Q6J1H4",506,{"v":1e-178,"d":"1.00E-178"},"Undifferentiated embryonic cell transcription factor 1",".",".",".",".","pfam13837","Myb_DNA-bind_4","Myb/SANT-like DNA-binding domain. This presumed domain appears to be related to other Myb/SANT-like DNA binding domains. In particular pfam10545 seems most related. This family is greatly expanded in plants and appears in several proteins annotated as transposon proteins.","GO:0008584|male gonad development;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0003713|transcription coactivator activity;GO:0017025|TBP-class protein binding;GO:0071837|HMG box domain binding;",".","."]
["ENSRNOG00000064728",11,0.925487955,55,3.5381741,0.261572192,-1.93471892,{"v":2.31162e-06,"d":"2.31E-06"},{"v":2.60481e-06,"d":"2.60E-06"},"down","yes","ENSRNOG00000064728","lncRNA","chr7:52119551-52120658:+","gi|12855414|dbj|BAB30329.1|",153,2E-8,"unnamed protein product [Mus musculus]","gi|259089668|gb|AC136025.3|",1104,0,"Rattus norvegicus CH230-236M3 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam05956","APC_basic","APC basic domain. This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.",".",".",".",".","."]
["ENSRNOG00000032639",32,2.692328597,101,6.497374257,0.414371789,-1.271002308,{"v":2.37958e-06,"d":"2.38E-06"},{"v":2.6775e-06,"d":"2.68E-06"},"down","yes","Foxo6","protein_coding","chr5:133856072-133876573:-","gi|109475418|ref|XP_001057233.1|",1080,{"v":8e-131,"d":"8.00E-131"},"PREDICTED: forkhead box protein O6 [Rattus norvegicus]","gi|564352641|ref|XM_001057233.4|",2124,0,"PREDICTED: Rattus norvegicus forkhead box O6 (Foxo6), mRNA","Q70KY4",417,{"v":4e-131,"d":"4.00E-131"},"Forkhead box protein O6","ECU01g0470",60.8,2e-09,"COG5025","pfam00250","Fork_head","Fork head domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0007613|memory;GO:0060999|positive regulation of dendritic spine development;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;","K17847","FOXO6; forkhead box protein O6"]
["ENSRNOG00000016222",17,1.430299567,69,4.438800235,0.322226613,-1.633852441,{"v":2.50674e-06,"d":"2.51E-06"},{"v":2.81361e-06,"d":"2.81E-06"},"down","yes","Ppp1r3g","protein_coding","chr17:28876482-28877525:-","gi|564319774|ref|XP_006222440.1|",1534,0,"PREDICTED: protein phosphatase 1 regulatory subunit 3G [Rattus norvegicus]","gi|564319773|ref|XM_006222378.1|",1044,0,"PREDICTED: Rattus norvegicus protein phosphatase 1, regulatory subunit 3G (Ppp1r3g), mRNA","Q9CW07",526,0,"Protein phosphatase 1 regulatory subunit 3G",".",".",".",".","pfam03370","CBM_21","Putative phosphatase regulatory subunit. This family consists of several eukaryotic proteins that are thought to be involved in the regulation of glycogen metabolizm. For instance, the mouse PTG protein has been shown to interact with glycogen synthase, phosphorylase kinase, phosphorylase a: these three enzymes have key roles in the regulation of glycogen metabolizm. PTG also binds the catalytic subunit of protein phosphatase 1 (PP1C) and localizes it to glycogen. Subsets of similar interactions have been observed with several other members of this family, such as the yeast PIG1, PIG2, GAC1 and GIP2 proteins. While the precise function of these proteins is not known, they may serve a scaffold function, bringing together the key enzymes in glycogen metabolizm. This family is a carbohydrate binding domain.","GO:0005979|regulation of glycogen biosynthetic process;GO:0042593|glucose homeostasis;GO:0045725|positive regulation of glycogen biosynthetic process;GO:2000467|positive regulation of glycogen (starch) synthase activity;","GO:0000164|protein phosphatase type 1 complex;GO:0005737|cytoplasm;","GO:0008157|protein phosphatase 1 binding;GO:0019903|protein phosphatase binding;GO:2001069|glycogen binding;",".","."]
["ENSRNOG00000068694",1,0.084135269,25,1.608260955,0.052314438,-4.256647015,{"v":2.78445e-06,"d":"2.78E-06"},{"v":3.11376e-06,"d":"3.11E-06"},"down","yes","ENSRNOG00000068694","lncRNA","chrX:130028910-130033581:-",".",".",".",".","gi|672032807|ref|XR_589812.1|",330,{"v":6e-171,"d":"6.00E-171"},"PREDICTED: Rattus norvegicus uncharacterized LOC103690083 (LOC103690083), transcript variant X40, ncRNA",".",".",".",".",".",".",".",".","pfam01603","B56","Protein phosphatase 2A regulatory B subunit (B56 family). Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolizm. The ability of this widely distributed heterotrimeric enzyme to act on a diverse array of substrates is largely controlled by the nature of its regulatory B subunit. There are multiple families of B subunits (See also pfam01240), this family is called the B56 family.",".",".",".",".","."]
["ENSRNOG00000068830",9,0.757217418,49,3.152191471,0.24021936,-2.057575668,{"v":3.44686e-06,"d":"3.45E-06"},{"v":3.81069e-06,"d":"3.81E-06"},"down","yes","ENSRNOG00000068830","lncRNA","chr16:9830085-9834146:+",".",".",".",".","gi|354785776|gb|JN950277.1|",235,{"v":7e-118,"d":"7.00E-118"},"Mus musculus targeted non-conditional, lacZ-tagged mutant allele 9230112D13Rik:tm1e(KOMP)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam00456","Transketolase_N","Transketolase, thiamine diphosphate binding domain. This family includes transketolase enzymes EC:2.2.1.1. and also partially matches to 2-oxoisovalerate dehydrogenase beta subunit EC:1.2.4.4. Both these enzymes utilize thiamine pyrophosphate as a cofactor, suggesting there may be common aspects in their mechanism of catalysis.",".",".",".",".","."]
["ENSRNOG00000033844",44,3.70195182,123,7.912643897,0.467852701,-1.095873712,{"v":3.69828e-06,"d":"3.70E-06"},{"v":4.07706e-06,"d":"4.08E-06"},"down","yes","Bex1","protein_coding","chrX:99219014-99220958:-","gi|82654212|ref|NP_001032442.1|",575,{"v":4E-70,"d":"4.00E-70"},"protein BEX1 [Rattus norvegicus]","gi|672036837|ref|XM_006229316.2|",762,0,"PREDICTED: Rattus norvegicus protein BEX1-like (LOC100912195), mRNA","Q3MKQ2",213,{"v":1e-66,"d":"1.00E-66"},"Protein BEX1",".",".",".",".","pfam04538","BEX","Brain expressed X-linked like family. This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.","GO:0002052|positive regulation of neuroblast proliferation;GO:0007165|signal transduction;GO:0031103|axon regeneration;GO:0045665|negative regulation of neuron differentiation;GO:0048011|neurotrophin TRK receptor signaling pathway;GO:0061564|axon development;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0005102|signaling receptor binding;GO:0005515|protein binding;",".","."]
["ENSRNOG00000055001",51,4.290898701,136,8.748939593,0.49044786,-1.027828325,{"v":3.87354e-06,"d":"3.87E-06"},{"v":4.26077e-06,"d":"4.26E-06"},"down","yes","AABR07005004.3","snoRNA","chr1:163540664-163540793:+",".",".",".",".","gi|908662943|tpe|LN872384.1|",110,{"v":2e-49,"d":"2.00E-49"},"TPA: Mus musculus SNORA3 (ACA3) gene for small nucleolar RNA SNORA3 (ACA3)",".",".",".",".",".",".",".",".","pfam10951","DUF2776","Protein of unknown function (DUF2776). This bacterial family of proteins has no known function.",".",".",".",".","."]
["ENSRNOG00000056209",25,2.103381716,85,5.468087246,0.384664988,-1.378325572,{"v":4.07813e-06,"d":"4.08E-06"},{"v":4.47497e-06,"d":"4.47E-06"},"down","yes","Exo1","protein_coding","chr13:87809810-87834654:+","gi|157821351|ref|NP_001100668.1|",4002,0,"exonuclease 1 [Rattus norvegicus]","gi|157821350|ref|NM_001107198.1|",4634,0,"Rattus norvegicus exonuclease 1 (Exo1), mRNA","Q9QZ11",1380,0,"Exonuclease 1","SPBC29A10.05",182,{"v":8e-47,"d":"8.00E-47"},"COG0258","pfam00867","XPG_I","XPG I-region.","GO:0002455|humoral immune response mediated by circulating immunoglobulin;GO:0006298|mismatch repair;GO:0006310|DNA recombination;GO:0008150|biological_process;GO:0016446|somatic hypermutation of immunoglobulin genes;GO:0045190|isotype switching;GO:0090305|nucleic acid phosphodiester bond hydrolysis;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0016604|nuclear body;","GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0035312|5'-3' exodeoxyribonuclease activity;GO:0045145|single-stranded DNA 5'-3' exodeoxyribonuclease activity;GO:0046872|metal ion binding;GO:0048256|flap endonuclease activity;GO:0051908|double-stranded DNA 5'-3' exodeoxyribonuclease activity;","K10746","EXO1; exonuclease 1 [EC:3.1.-.-]"]
["ENSRNOG00000027949",8,0.673082149,46,2.959200157,0.22745408,-2.136352781,{"v":4.09001e-06,"d":"4.09E-06"},{"v":4.4862e-06,"d":"4.49E-06"},"down","yes","Rfx6","protein_coding","chr20:31019829-31073147:+","gi|564397930|ref|XP_006256506.1|",4823,0,"PREDICTED: DNA-binding protein RFX6 isoform X2 [Rattus norvegicus]","gi|672086182|ref|XM_006256444.2|",3396,0,"PREDICTED: Rattus norvegicus regulatory factor X, 6 (Rfx6), transcript variant X2, mRNA","Q8C7R7",1716,0,"DNA-binding protein RFX6",".",".",".",".","pfam02257","RFX_DNA_binding","RFX DNA-binding domain. RFX is a regulatory factor which binds to the X box of MHC class II genes and is essential for their expression. The DNA-binding domain of RFX is the central domain of the protein and binds ssDNA as either a monomer or homodimer. It recognize X-boxes (DNA of the sequence 5'-GTNRCC(0-3N)RGYAAC-3', where N is any nucleotide, R is a purine and Y is a pyrimidine) using a highly conserved 76-residue DNA-binding domain (DBD).","GO:0003309|type B pancreatic cell differentiation;GO:0003310|pancreatic A cell differentiation;GO:0003311|pancreatic D cell differentiation;GO:0006357|regulation of transcription by RNA polymerase II;GO:0031018|endocrine pancreas development;GO:0035774|positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0042593|glucose homeostasis;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050796|regulation of insulin secretion;GO:0090104|pancreatic epsilon cell differentiation;","GO:0005634|nucleus;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;","K19521","RFX6; regulatory factor X 6"]
["ENSRNOG00000033528",10,0.841352686,51,3.280852347,0.256443326,-1.963288072,{"v":4.36025e-06,"d":"4.36E-06"},{"v":4.76534e-06,"d":"4.77E-06"},"down","yes","Tll1","protein_coding","chr16:25509146-25709543:+","gi|157823867|ref|NP_001099551.1|",5487,0,"tolloid-like protein 1 precursor [Rattus norvegicus]","gi|157823866|ref|NM_001106081.1|",4721,0,"Rattus norvegicus tolloid-like 1 (Tll1), mRNA","Q62381",2086,0,"Tolloid-like protein 1",".",".",".",".","pfam01400","Astacin","Astacin (Peptidase family M12A). The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family contain two conserved disulphide bridges, these are joined 1-4 and 2-3. Members of this family have an amino terminal propeptide which is cleaved to give the active protease domain. All other linked domains are found to the carboxyl terminus of this domain. This family includes: Astacin, a digestive enzyme from Crayfish. Meprin, a multiple domain membrane component that is constructed from a homologous alpha and beta chain. Proteins involved in morphogenesis, and Tolloid from drosophila.","GO:0006508|proteolysis;GO:0030154|cell differentiation;",".","GO:0004222|metalloendopeptidase activity;GO:0005509|calcium ion binding;GO:0005518|collagen binding;GO:0008270|zinc ion binding;","K09608","TLL1; tolloid-like protein 1 [EC:3.4.24.-]"]
["ENSRNOG00000003669",53,4.459169238,139,8.941930908,0.498680798,-1.003811443,{"v":4.68019e-06,"d":"4.68E-06"},{"v":5.09658e-06,"d":"5.10E-06"},"down","yes","Myocd","protein_coding","chr10:49836641-49927627:-","gi|564372506|ref|XP_006246644.1|",4283,0,"PREDICTED: myocardin isoform X1 [Rattus norvegicus]","gi|672067688|ref|XM_006246582.2|",3783,0,"PREDICTED: Rattus norvegicus myocardin (Myocd), transcript variant X1, mRNA","Q8R5I7",1578,0,"Myocardin",".",".",".",".","pfam02037","SAP","SAP domain. The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001560|regulation of cell growth by extracellular stimulus;GO:0001570|vasculogenesis;GO:0001666|response to hypoxia;GO:0003231|cardiac ventricle development;GO:0003257|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007507|heart development;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0010628|positive regulation of gene expression;GO:0010667|negative regulation of cardiac muscle cell apoptotic process;GO:0010718|positive regulation of epithelial to mesenchymal transition;GO:0010832|negative regulation of myotube differentiation;GO:0030511|positive regulation of transforming growth factor beta receptor signaling pathway;GO:0035065|regulation of histone acetylation;GO:0035733|hepatic stellate cell activation;GO:0035886|vascular smooth muscle cell differentiation;GO:0042692|muscle cell differentiation;GO:0043388|positive regulation of DNA binding;GO:0043954|cellular component maintenance;GO:0045661|regulation of myoblast differentiation;GO:0045736|negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0045987|positive regulation of smooth muscle contraction;GO:0048286|lung alveolus development;GO:0048565|digestive tract development;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051145|smooth muscle cell differentiation;GO:0051150|regulation of smooth muscle cell differentiation;GO:0051152|positive regulation of smooth muscle cell differentiation;GO:0055007|cardiac muscle cell differentiation;GO:0055012|ventricular cardiac muscle cell differentiation;GO:0060065|uterus development;GO:0060157|urinary bladder development;GO:0060354|negative regulation of cell adhesion molecule production;GO:0061049|cell growth involved in cardiac muscle cell development;GO:0071363|cellular response to growth factor stimulus;GO:0071456|cellular response to hypoxia;GO:0097070|ductus arteriosus closure;GO:1900222|negative regulation of amyloid-beta clearance;GO:1900239|regulation of phenotypic switching;GO:1901228|positive regulation of transcription from RNA polymerase II promoter involved in heart development;GO:1903800|positive regulation of production of miRNAs involved in gene silencing by miRNA;GO:1904706|negative regulation of vascular smooth muscle cell proliferation;GO:1904753|negative regulation of vascular associated smooth muscle cell migration;GO:2000587|negative regulation of platelet-derived growth factor receptor-beta signaling pathway;GO:2000721|positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation;GO:2000724|positive regulation of cardiac vascular smooth muscle cell differentiation;GO:2000727|positive regulation of cardiac muscle cell differentiation;GO:2001015|negative regulation of skeletal muscle cell differentiation;","GO:0000785|chromatin;GO:0005634|nucleus;","GO:0003713|transcription coactivator activity;GO:0005515|protein binding;GO:0035035|histone acetyltransferase binding;GO:0042826|histone deacetylase binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;GO:0070412|R-SMAD binding;","K22526","MYOCD; myocardin"]
["ENSRNOG00000028436",1,0.084135269,24,1.543930516,0.054494207,-4.197753326,{"v":4.77693e-06,"d":"4.78E-06"},{"v":5.19674E-6,"d":"5.20E-06"},"down","yes","Rprml","protein_coding","chr10:88560248-88561252:+","gi|85701722|ref|NP_001028384.1|",606,{"v":2e-75,"d":"2.00E-75"},"reprimo-like protein [Mus musculus]","gi|157823288|ref|NM_001109481.1|",1005,0,"Rattus norvegicus reprimo-like (Rprml), mRNA","Q3URD2",238,{"v":8e-77,"d":"8.00E-77"},"Reprimo-like protein",".",".",".",".","pfam15402","Spc7_N","N-terminus of kinetochore NMS complex subunit Spc7.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000048071",21,1.766840642,76,4.889113302,0.361382634,-1.468400916,{"v":4.89019e-06,"d":"4.89E-06"},{"v":5.3104E-6,"d":"5.31E-06"},"down","yes","Ccdc89","protein_coding","chr1:144386158-144389850:+","gi|198386330|ref|NP_001128305.1|",1615,0,"coiled-coil domain-containing protein 89 [Rattus norvegicus]","gi|672037594|ref|XM_003748922.3|",2206,0,"PREDICTED: Rattus norvegicus coiled-coil domain-containing protein 89-like (LOC100911776), mRNA","B2RZ86",626,0,"Coiled-coil domain-containing protein 89",".",".",".",".","pfam01576","Myosin_tail_1","Myosin tail. The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.",".",".",".",".","."]
["ENSRNOG00000049269",33,2.776463865,100,6.433043818,0.431594117,-1.212252896,{"v":6.08016e-06,"d":"6.08E-06"},{"v":6.53277E-6,"d":"6.53E-06"},"down","yes","ENSRNOG00000049269","protein_coding","chr4:150927710-150929409:-","gi|158186649|ref|NP_036686.2|",1649,0,"alpha-enolase [Rattus norvegicus]","gi|672050945|ref|XR_353580.2|",667,0,"PREDICTED: Rattus norvegicus similar to Alpha enolase (2-phospho-D-glycerate hydro-lyase) (RGD1563294), transcript variant X2, misc_RNA","P04764",639,0,"Alpha-enolase","YGR254w",383,{"v":2e-129,"d":"2.00E-129"},"COG0148","pfam00113","Enolase_C","Enolase, C-terminal TIM barrel domain.",".",".",".",".","."]
["ENSRNOG00000004195",46,3.870222358,125,8.041304773,0.481292833,-1.055013154,{"v":6.09412e-06,"d":"6.09E-06"},{"v":6.54597e-06,"d":"6.55E-06"},"down","yes","Dtl","protein_coding","chr13:103117186-103154890:-","gi|564316400|ref|XP_001068900.3|",3322,0,"PREDICTED: denticleless protein homolog isoform X1 [Rattus norvegicus]","gi|564382379|ref|XM_223074.7|",2817,0,"PREDICTED: Rattus norvegicus denticleless E3 ubiquitin protein ligase homolog (Drosophila) (Dtl), transcript variant X1, mRNA","Q3TLR7",1186,0,"Denticleless protein homolog",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.","GO:0000209|protein polyubiquitination;GO:0006511|ubiquitin-dependent protein catabolic process;GO:0006513|protein monoubiquitination;GO:0006974|cellular response to DNA damage stimulus;GO:0007095|mitotic G2 DNA damage checkpoint;GO:0009411|response to UV;GO:0010971|positive regulation of G2/M transition of mitotic cell cycle;GO:0019985|translesion synthesis;GO:0045732|positive regulation of protein catabolic process;GO:0051726|regulation of cell cycle;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005813|centrosome;GO:0005829|cytosol;GO:0031464|Cul4A-RING E3 ubiquitin ligase complex;GO:0031465|Cul4B-RING E3 ubiquitin ligase complex;GO:0080008|Cul4-RING E3 ubiquitin ligase complex;","GO:0004842|ubiquitin-protein transferase activity;","K11790","DTL, CDT2, DCAF2; denticleless"]
["ENSRNOG00000046390",15,1.26202903,62,3.988487167,0.316417974,-1.66009654,{"v":6.37633e-06,"d":"6.38E-06"},{"v":6.83294e-06,"d":"6.83E-06"},"down","yes","Tceal3","protein_coding","chrX:100010690-100012654:+","gi|148691879|gb|EDL23826.1|",628,{"v":9e-77,"d":"9.00E-77"},"mCG114170, isoform CRA_a, partial [Mus musculus]","gi|672088353|ref|XM_577026.6|",1080,0,"PREDICTED: Rattus norvegicus transcription elongation factor A (SII)-like 3 (Tceal3), mRNA","Q8R0A5",224,{"v":4E-70,"d":"4.00E-70"},"Transcription elongation factor A protein-like 3",".",".",".",".","pfam04538","BEX","Brain expressed X-linked like family. This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.",".","GO:0005634|nucleus;","GO:0050699|WW domain binding;",".","."]
["ENSRNOG00000057240",8,0.673082149,45,2.894869718,0.232508615,-2.104643922,{"v":6.37633e-06,"d":"6.38E-06"},{"v":6.83294e-06,"d":"6.83E-06"},"down","yes","Snord49b","snoRNA","chr10:47296946-47297016:+",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","pfam06434","Aconitase_2_N","Aconitate hydratase 2 N-terminus. This family represents the N-terminal region of several bacterial Aconitate hydratase 2 proteins and is found in conjunction with pfam00330.",".",".",".",".","."]
["ENSRNOG00000012363",44,3.70195182,121,7.78398302,0.475585804,-1.072222444,{"v":6.50536e-06,"d":"6.51E-06"},{"v":6.96434e-06,"d":"6.96E-06"},"down","yes","Peli2","protein_coding","chr15:21393262-21535106:+","gi|157822359|ref|NP_001100729.1|",2271,0,"E3 ubiquitin-protein ligase pellino homolog 2 [Rattus norvegicus]","gi|157822358|ref|NM_001107259.1|",3239,0,"Rattus norvegicus pellino E3 ubiquitin protein ligase family member 2 (Peli2), mRNA","Q8BST6",850,0,"E3 ubiquitin-protein ligase pellino homolog 2",".",".",".",".","pfam04710","Pellino","Pellino. Pellino is involved in Toll-like signalling pathways, and associates with the kinase domain of the Pelle Ser/Thr kinase.","GO:0000209|protein polyubiquitination;GO:0001934|positive regulation of protein phosphorylation;GO:0008063|Toll signaling pathway;GO:0008150|biological_process;GO:0008592|regulation of Toll signaling pathway;GO:0043410|positive regulation of MAPK cascade;","GO:0005575|cellular_component;GO:0005829|cytosol;GO:0016020|membrane;","GO:0003674|molecular_function;GO:0030674|protein binding, bridging;GO:0061630|ubiquitin protein ligase activity;","K11964","PELI; pellino [EC:2.3.2.27]"]
["ENSRNOG00000000237",51,4.290898701,134,8.620278717,0.497767977,-1.006454674,{"v":6.62777e-06,"d":"6.63E-06"},{"v":7.08704e-06,"d":"7.09E-06"},"down","yes","RGD1310429","protein_coding","chr10:65360924-65373864:-","gi|213385313|ref|NP_001132978.1|",1944,0,"uncharacterized protein LOC303764 [Rattus norvegicus]","gi|213385312|ref|NM_001139506.1|",2198,0,"Rattus norvegicus similar to Protein Njmu-R1 (RGD1310429), mRNA",".",".",".",".",".",".",".",".","pfam15053","Njmu-R1","Mjmu-R1-like protein family. This protein family is thought to have a role in spermatogenesis. This family of proteins is found in eukaryotes. In humans, it is found in chromosome 17 open reading frame 75 (C17orf75). Proteins in this family are typically between 217 and 399 amino acids in length.","GO:0006886|intracellular protein transport;GO:0099041|vesicle tethering to Golgi;","GO:0005802|trans-Golgi network;GO:0031410|cytoplasmic vesicle;",".",".","."]
["ENSRNOG00000066818",2,0.168270537,27,1.736921831,0.09687859,-3.367678327,{"v":6.97076E-6,"d":"6.97E-06"},{"v":7.4421e-06,"d":"7.44E-06"},"down","yes","ENSRNOG00000066818","lncRNA","chr1:39289190-39330338:+","gi|672072106|ref|XP_006248795.2|",361,{"v":1E-73,"d":"1.00E-73"},"PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC302022 isoform X1 [Rattus norvegicus]","gi|672033277|ref|XR_349384.2|",1173,0,"PREDICTED: Rattus norvegicus similar to nidogen 2 (LOC367597), transcript variant X5, misc_RNA","B5DFC9",115,{"v":6e-66,"d":"6.00E-66"},"Nidogen-2",".",".",".",".","pfam06119","NIDO","Nidogen-like. This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function.",".",".",".",".","."]
["ENSRNOG00000069950",2,0.168270537,27,1.736921831,0.09687859,-3.367678327,{"v":6.97076E-6,"d":"6.97E-06"},{"v":7.4421e-06,"d":"7.44E-06"},"down","yes","ENSRNOG00000069950","lncRNA","chr1:244135543-244141053:+","gi|37654282|gb|AAQ96246.1|",1450,0,"LRRGT00033 [Rattus norvegicus]","gi|969987293|gb|KU095826.1|",3682,0,"Rattus norvegicus strain SHR.BN-D1Mit3/Igf2 folate receptor 1 (FOLr1) gene, promoter region","P11227",503,0,"Gag-Pol polyprotein","SPAC167.08",78.6,{"v":2e-13,"d":"2.00E-13"},"COG2801","pfam02093","Gag_p30","Gag P30 core shell protein. According to Swiss-Prot annotation this protein is the viral core shell protein. P30 is essential for viral assembly.",".",".",".",".","."]
["ENSRNOG00000047450",16,1.346164298,64,4.117148044,0.32696524,-1.612790825,{"v":7.06477e-06,"d":"7.06E-06"},{"v":7.53508e-06,"d":"7.54E-06"},"down","yes","Lmo3","protein_coding","chr4:171234696-171292222:-","gi|507978880|ref|XP_004693296.1|",800,{"v":3e-99,"d":"3.00E-99"},"PREDICTED: LIM domain only protein 3 isoform X1 [Condylura cristata]","gi|298903718|emb|FQ213730.1|",2067,0,"Rattus norvegicus TL0AAA46YB03 mRNA sequence","Q9YH16",304,{"v":1E-97,"d":"1.00E-97"},"LIM domain only protein 3",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.","GO:0035360|positive regulation of peroxisome proliferator activated receptor signaling pathway;GO:0045600|positive regulation of fat cell differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:2000324|positive regulation of glucocorticoid receptor signaling pathway;","GO:0005737|cytoplasm;","GO:0046872|metal ion binding;","K24098","LMO1_3; rhombotin-1/3"]
["ENSRNOG00000068530",16,1.346164298,64,4.117148044,0.32696524,-1.612790825,{"v":7.06477e-06,"d":"7.06E-06"},{"v":7.53508e-06,"d":"7.54E-06"},"down","yes","ENSRNOG00000068530","lncRNA","chr5:160221773-160230937:+","gi|149060708|gb|EDM11422.1|",138,7e-07,"rCG52991, isoform CRA_d [Rattus norvegicus]","gi|158935803|emb|CU459142.15|",373,0,"Mouse DNA sequence from clone DN-109K13 on chromosome 4, complete sequence",".",".",".",".",".",".",".",".","pfam05748","Rubella_E1","Rubella membrane glycoprotein E1. Rubella virus (RV), the sole member of the genus Rubivirus within the family Togaviridae, is a small enveloped, positive strand RNA virus. The nucleocapsid consists of 40S genomic RNA and a single species of capsid protein which is enveloped within a host-derived lipid bilayer containing two viral glycoproteins, E1 (58 kDa) and E2 (42-46 kDa). In virus infected cells, RV matures by budding either at the plasma membrane, or at the internal membranes depending on the cell type and enters adjacent uninfected cells by a membrane fusion process in the endosome, directed by E1-E2 heterodimers. The heterodimer formation is crucial for E1 transport out of the endoplasmic reticulum to the Golgi and plasma membrane. In RV E1, a cysteine at position 82 is crucial for the E1-E2 heterodimer formation and cell surface expression of the two proteins. The E1 has been shown to be a type 1 membrane protein, rich in cysteine residues with extensive intramolecular disulfide bonds.",".",".",".",".","."]
["ENSRNOG00000052802",13,1.093758492,57,3.666834977,0.298284079,-1.745241121,{"v":7.35953E-6,"d":"7.36E-06"},{"v":7.83718e-06,"d":"7.84E-06"},"down","yes","Aldoa","protein_coding","chr1:181402275-181406182:-","gi|564330881|ref|XP_006230271.1|",2133,0,"PREDICTED: fructose-bisphosphate aldolase A isoform X2 [Rattus norvegicus]","gi|672038361|ref|XM_006230210.2|",1545,0,"PREDICTED: Rattus norvegicus aldolase A, fructose-bisphosphate (Aldoa), transcript variant X1, mRNA","P05065",715,0,"Fructose-bisphosphate aldolase A","AGl2190",323,{"v":8e-105,"d":"8.00E-105"},"COG3588","pfam00274","Glycolytic","Fructose-bisphosphate aldolase class-I.","GO:0001666|response to hypoxia;GO:0006000|fructose metabolic process;GO:0006096|glycolytic process;GO:0006754|ATP biosynthetic process;GO:0006941|striated muscle contraction;GO:0007339|binding of sperm to zona pellucida;GO:0008360|regulation of cell shape;GO:0009408|response to heat;GO:0019242|methylglyoxal biosynthetic process;GO:0030335|positive regulation of cell migration;GO:0030388|fructose 1,6-bisphosphate metabolic process;GO:0032496|response to lipopolysaccharide;GO:0035094|response to nicotine;GO:0043627|response to estrogen;GO:0046716|muscle cell cellular homeostasis;GO:0051289|protein homotetramerization;","GO:0000792|heterochromatin;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0015629|actin cytoskeleton;GO:0016020|membrane;GO:0030018|Z disc;GO:0031430|M band;GO:0032991|protein-containing complex;GO:0035686|sperm fibrous sheath;GO:0061827|sperm head;GO:0070062|extracellular exosome;","GO:0002020|protease binding;GO:0003674|molecular_function;GO:0004332|fructose-bisphosphate aldolase activity;GO:0005515|protein binding;GO:0008092|cytoskeletal protein binding;GO:0042802|identical protein binding;GO:0070061|fructose binding;","K01623","ALDO; fructose-bisphosphate aldolase, class I [EC:4.1.2.13]"]
["ENSRNOG00000019680",7,0.588946881,42,2.701878404,0.217976827,-2.197753326,{"v":7.44703e-06,"d":"7.45E-06"},{"v":7.92881e-06,"d":"7.93E-06"},"down","yes","Mst1","protein_coding","chr8:108768839-108773416:+","gi|564365338|ref|XP_006243768.1|",3856,0,"PREDICTED: hepatocyte growth factor-like protein isoform X1 [Rattus norvegicus]","gi|564365337|ref|XM_006243706.1|",2298,0,"PREDICTED: Rattus norvegicus Macrophage stimulating 1 (hepatocyte growth factor-like) (Mst1), transcript variant X1, mRNA","P26928",1361,0,"Hepatocyte growth factor-like protein","VC1649",73.9,{"v":7e-13,"d":"7.00E-13"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;GO:0007283|spermatogenesis;GO:0007566|embryo implantation;GO:0010628|positive regulation of gene expression;GO:0010758|regulation of macrophage chemotaxis;GO:0030317|flagellated sperm motility;GO:0030879|mammary gland development;GO:0033601|positive regulation of mammary gland epithelial cell proliferation;GO:0035978|histone H2A-S139 phosphorylation;GO:0045721|negative regulation of gluconeogenesis;GO:0046425|regulation of JAK-STAT cascade;GO:0060763|mammary duct terminal end bud growth;GO:0071456|cellular response to hypoxia;GO:1904036|negative regulation of epithelial cell apoptotic process;GO:2000479|regulation of cAMP-dependent protein kinase activity;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005773|vacuole;","GO:0005102|signaling receptor binding;GO:0019899|enzyme binding;GO:0030971|receptor tyrosine kinase binding;","K23441","MST1; hepatocyte growth factor-like protein"]
["ENSRNOG00000067940",11,0.925487955,52,3.345182786,0.276662895,-1.853798925,{"v":8.06457e-06,"d":"8.06E-06"},{"v":8.56285e-06,"d":"8.56E-06"},"down","yes","ENSRNOG00000067940","lncRNA","chr2:182593209-182598658:+","gi|67975423|ref|XP_668908.1|",162,{"v":5e-10,"d":"5.00E-10"},"hypothetical protein [Plasmodium berghei strain ANKA], partial [Plasmodium berghei ANKA]","gi|40841709|gb|AC130969.4|",4555,0,"Rattus norvegicus 2 BAC CH230-105B13 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam06085","Rz1","Lipoprotein Rz1 precursor. This family consists of several bacteria and phage lipoprotein Rz1 precursors. Rz1 is a proline-rich lipoprotein from bacteriophage lambda which is known to have fusogenic properties. Rz1-induced liposome fusion is thought to be mediated primarily by the generation of local perturbation in the bilayer lipid membrane and to a lesser extent by electrostatic forces. This family Rz1 and the Rz protein Rz (pfam03245) represent a unique example of two genes located in different reading frames in the same nucleotide sequence, which encode different proteins that are both required in the same physiological pathway.",".",".",".",".","."]
["ENSRNOG00000062876",9,0.757217418,47,3.023530595,0.25044146,-1.997454676,{"v":8.20092e-06,"d":"8.20E-06"},{"v":8.69729e-06,"d":"8.70E-06"},"down","yes","ENSRNOG00000062876","lncRNA","chr1:203300654-203314154:+",".",".",".",".","gi|34494980|gb|AC131114.3|",135,{"v":2e-62,"d":"2.00E-62"},"Mus musculus BAC clone RP24-212G16 from chromosome 19, complete sequence",".",".",".",".",".",".",".",".","pfam11725","AvrE","Pathogenicity factor. This family is secreted by gram-negative Gammaproteobacteria such as Pseudomonas syringae of tomato and the fire blight plant pathogen Erwinia amylovora, amongst others. It is an essential pathogenicity factor of approximately 198 kDa. Its injection into the host-plant is dependent upon the bacterial type III or Hrp secretion system. The family is long and carries a number of predicted functional regions, including an ERMS or endoplasmic reticulum membrane retention signal at both the C- and the N-termini, a leucine-zipper motif from residues 539-560, and a nuclear localisation signal at 1358-1361. this conserved AvrE-family of effectors is among the few that are required for full virulence of many phytopathogenic pseudomonads, erwinias and pantoeas.",".",".",".",".","."]
["ENSRNOG00000011107",1,0.084135269,23,1.479600078,0.05686352,-4.136352781,{"v":8.20593e-06,"d":"8.21E-06"},{"v":8.69769e-06,"d":"8.70E-06"},"down","yes","Pcsk1","protein_coding","chr2:4395543-4442434:+","gi|8393919|ref|NP_058787.1|",3995,0,"neuroendocrine convertase 1 precursor [Rattus norvegicus]","gi|77695924|ref|NM_017091.2|",5046,0,"Rattus norvegicus proprotein convertase subtilisin/kexin type 1 (Pcsk1), mRNA","P28840",1543,0,"Neuroendocrine convertase 1","YNL238w_1",301,{"v":1e-88,"d":"1.00E-88"},"COG1404","pfam00082","Peptidase_S8","Subtilase family. Subtilases are a family of serine proteases. They appear to have independently and convergently evolved an Asp/Ser/His catalytic triad, like that found in the trypsin serine proteases (see pfam00089). Structure is an alpha/beta fold containing a 7-stranded parallel beta sheet, order 2314567.","GO:0006508|proteolysis;GO:0009410|response to xenobiotic stimulus;GO:0009749|response to glucose;GO:0010035|response to inorganic substance;GO:0010157|response to chlorate;GO:0014070|response to organic cyclic compound;GO:0016485|protein processing;GO:0016486|peptide hormone processing;GO:0016540|protein autoprocessing;GO:0021983|pituitary gland development;GO:0022008|neurogenesis;GO:0031016|pancreas development;GO:0031667|response to nutrient levels;GO:0032496|response to lipopolysaccharide;GO:0043043|peptide biosynthetic process;GO:0043278|response to morphine;GO:0043434|response to peptide hormone;GO:0048678|response to axon injury;GO:0050714|positive regulation of protein secretion;GO:0051384|response to glucocorticoid;GO:0051592|response to calcium ion;GO:0070542|response to fatty acid;GO:0070555|response to interleukin-1;","GO:0005615|extracellular space;GO:0005791|rough endoplasmic reticulum;GO:0005802|trans-Golgi network;GO:0016020|membrane;GO:0030133|transport vesicle;GO:0030141|secretory granule;GO:0030425|dendrite;GO:0034774|secretory granule lumen;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0043679|axon terminus;GO:0048471|perinuclear region of cytoplasm;","GO:0004175|endopeptidase activity;GO:0004252|serine-type endopeptidase activity;GO:0042802|identical protein binding;","K01359","PCSK1; proprotein convertase subtilisin/kexin type 1 [EC:3.4.21.93]"]
["ENSRNOG00000017159",1,0.084135269,23,1.479600078,0.05686352,-4.136352781,{"v":8.20593e-06,"d":"8.21E-06"},{"v":8.69769e-06,"d":"8.70E-06"},"down","yes","Dsc3","protein_coding","chr18:11377347-11413797:-","gi|157823393|ref|NP_001100872.1|",4809,0,"desmocollin-3 [Rattus norvegicus]","gi|133778946|ref|NM_007882.3|",3235,0,"Mus musculus desmocollin 3 (Dsc3), transcript variant 1, mRNA","P55850",1729,0,"Desmocollin-3",".",".",".",".","pfam01049","Cadherin_C","Cadherin cytoplasmic region. Cadherins are vital in cell-cell adhesion during tissue differentiation. Cadherins are linked to the cytoskeleton by catenins. Catenins bind to the cytoplasmic tail of the cadherin. Cadherins cluster to form foci of homophilic binding units. A key determinant to the strength of the binding that it is mediated by cadherins is the juxtamembrane region of the cadherin. This region induces clustering and also binds to the protein p120ctn.","GO:0001701|in utero embryonic development;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0050821|protein stabilization;GO:0098609|cell-cell adhesion;","GO:0005576|extracellular region;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0016021|integral component of membrane;GO:0030054|cell junction;GO:0030057|desmosome;","GO:0005509|calcium ion binding;GO:0045295|gamma-catenin binding;","K07602","DSC3; desmocollin 3"]
["ENSRNOG00000005888",32,2.692328597,97,6.240052504,0.431459286,-1.212703667,{"v":8.33007e-06,"d":"8.33E-06"},{"v":8.82239e-06,"d":"8.82E-06"},"down","yes","Fsip1","protein_coding","chr3:105068543-105217167:-","gi|568918400|ref|XP_006500238.1|",2256,0,"PREDICTED: fibrous sheath-interacting protein 1 isoform X1 [Mus musculus]","gi|672017174|ref|XM_008775475.1|",1772,0,"PREDICTED: Rattus norvegicus fibrous sheath-interacting protein 1-like (LOC103691868), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam15554","FSIP1","FSIP1 family.",".",".",".",".","."]
["ENSRNOG00000013290",14,1.177893761,59,3.795495853,0.310339889,-1.688078953,{"v":8.36912e-06,"d":"8.37E-06"},{"v":8.85859e-06,"d":"8.86E-06"},"down","yes","Nrip3","protein_coding","chr1:163789738-163815600:-","gi|49117530|gb|AAH72641.1|",1172,{"v":5e-147,"d":"5.00E-147"},"Nrip3 protein [Mus musculus]","gi|157817419|ref|NM_001108498.1|",3770,0,"Rattus norvegicus nuclear receptor interacting protein 3 (Nrip3), mRNA","Q9JJR9",427,{"v":7e-138,"d":"7.00E-138"},"Nuclear receptor-interacting protein 3",".",".",".",".","pfam09668","Asp_protease","Aspartyl protease. This family of eukaryotic aspartyl proteases have a fold similar to retroviral proteases which implies they function proteolytically during regulated protein turnover.","GO:0006508|proteolysis;",".","GO:0004190|aspartic-type endopeptidase activity;",".","."]
["ENSRNOG00000001911",6,0.504811612,39,2.508887089,0.201209378,-2.313230543,{"v":8.4153e-06,"d":"8.42E-06"},{"v":8.89838e-06,"d":"8.90E-06"},"down","yes","Map6d1","protein_coding","chr11:80734148-80740377:+","gi|157819433|ref|NP_001102314.1|",984,{"v":1e-129,"d":"1.00E-129"},"MAP6 domain-containing protein 1 [Rattus norvegicus]","gi|157819432|ref|NM_001108844.1|",1331,0,"Rattus norvegicus MAP6 domain containing 1 (Map6d1), mRNA","Q14BB9",363,{"v":3e-123,"d":"3.00E-123"},"MAP6 domain-containing protein 1",".",".",".",".","pfam05217","STOP","STOP protein. Neurons contain abundant subsets of highly stable microtubules that resist de-polymerising conditions such as exposure to the cold. Stable microtubules are thought to be essential for neuronal development, maintenance, and function. STOP is a major factor responsible for the intriguing stability properties of neuronal microtubules and is important for synaptic plasticity. Additionally knowledge of STOPs function and properties may help in the treatment of neuroleptics in illnesses such as schizophrenia, currently thought to result from synaptic defects.","GO:0000226|microtubule cytoskeleton organization;GO:0007026|negative regulation of microtubule depolymerization;GO:0018009|N-terminal peptidyl-L-cysteine N-palmitoylation;GO:0030705|cytoskeleton-dependent intracellular transport;GO:0070507|regulation of microtubule cytoskeleton organization;","GO:0005798|Golgi-associated vesicle;GO:0005801|cis-Golgi network;GO:0005874|microtubule;","GO:0005516|calmodulin binding;GO:0008017|microtubule binding;",".","."]
["ENSRNOG00000050123",6,0.504811612,39,2.508887089,0.201209378,-2.313230543,{"v":8.4153e-06,"d":"8.42E-06"},{"v":8.89838e-06,"d":"8.90E-06"},"down","yes","Gdf5","protein_coding","chr3:144454338-144458612:-","gi|109471161|ref|XP_001066344.1|",2260,0,"PREDICTED: growth/differentiation factor 5 [Rattus norvegicus]","gi|672017615|ref|XM_001066344.5|",2327,0,"PREDICTED: Rattus norvegicus growth differentiation factor 5 (Gdf5), mRNA","P43027",849,0,"Growth/differentiation factor 5",".",".",".",".","pfam00019","TGF_beta","Transforming growth factor beta like domain.","GO:0007178|transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0009612|response to mechanical stimulus;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0030326|embryonic limb morphogenesis;GO:0030509|BMP signaling pathway;GO:0030513|positive regulation of BMP signaling pathway;GO:0032331|negative regulation of chondrocyte differentiation;GO:0032332|positive regulation of chondrocyte differentiation;GO:0035136|forelimb morphogenesis;GO:0035137|hindlimb morphogenesis;GO:0040014|regulation of multicellular organism growth;GO:0043524|negative regulation of neuron apoptotic process;GO:0043932|ossification involved in bone remodeling;GO:0045666|positive regulation of neuron differentiation;GO:0050680|negative regulation of epithelial cell proliferation;GO:0060390|regulation of SMAD protein signal transduction;GO:0060395|SMAD protein signal transduction;GO:0060591|chondroblast differentiation;GO:2001054|negative regulation of mesenchymal cell apoptotic process;","GO:0005575|cellular_component;GO:0005615|extracellular space;","GO:0005102|signaling receptor binding;GO:0005125|cytokine activity;GO:0008083|growth factor activity;GO:0036122|BMP binding;GO:0042802|identical protein binding;","K04664","GDF5; growth differentiation factor 5"]
["ENSRNOG00000004918",3,0.252405806,30,1.929913146,0.130786096,-2.93471892,{"v":8.5759e-06,"d":"8.58E-06"},{"v":9.05809e-06,"d":"9.06E-06"},"down","yes","Kcna4","protein_coding","chr3:93756446-93769162:+","gi|564342168|ref|XP_006234735.1|",2506,0,"PREDICTED: potassium voltage-gated channel subfamily A member 4 isoform X1 [Rattus norvegicus]","gi|755498782|ref|XM_006498812.2|",6020,0,"PREDICTED: Mus musculus potassium voltage-gated channel, shaker-related subfamily, member 4 (Kcna4), transcript variant X1, mRNA","Q61423",967,0,"Potassium voltage-gated channel subfamily A member 4","MA2034",70.9,{"v":7e-12,"d":"7.00E-12"},"COG1226","pfam02214","BTB_2","BTB/POZ domain. In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.","GO:0006813|potassium ion transport;GO:0034765|regulation of ion transmembrane transport;GO:0051260|protein homooligomerization;GO:0071805|potassium ion transmembrane transport;","GO:0005783|endoplasmic reticulum;GO:0005887|integral component of plasma membrane;GO:0008076|voltage-gated potassium channel complex;GO:0009986|cell surface;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0032279|asymmetric synapse;GO:0043197|dendritic spine;GO:0043198|dendritic shaft;GO:0098978|glutamatergic synapse;GO:0099055|integral component of postsynaptic membrane;GO:0099056|integral component of presynaptic membrane;","GO:0005216|ion channel activity;GO:0005249|voltage-gated potassium channel activity;GO:0005251|delayed rectifier potassium channel activity;GO:0005267|potassium channel activity;GO:0005515|protein binding;GO:0030955|potassium ion binding;","K04877","KCNA4, KV1.4; potassium voltage-gated channel Shaker-related subfamily A member 4"]
["ENSRNOG00000001092",19,1.598570104,70,4.503130673,0.354990832,-1.494146329,{"v":8.89658e-06,"d":"8.90E-06"},{"v":9.38043e-06,"d":"9.38E-06"},"down","yes","Kl","protein_coding","chr12:490399-530080:+","gi|13786168|ref|NP_112626.1|",4910,0,"klotho precursor [Rattus norvegicus]","gi|13786167|ref|NM_031336.1|",3500,0,"Rattus norvegicus Klotho (Kl), mRNA","Q9Z2Y9",1897,0,"Klotho","BH1923",198,{"v":1E-53,"d":"1.00E-53"},"COG2723","pfam00232","Glyco_hydro_1","Glycosyl hydrolase family 1.","GO:0002526|acute inflammatory response;GO:0003085|negative regulation of systemic arterial blood pressure;GO:0005975|carbohydrate metabolic process;GO:0006112|energy reserve metabolic process;GO:0007568|aging;GO:0008286|insulin receptor signaling pathway;GO:0008543|fibroblast growth factor receptor signaling pathway;GO:0014823|response to activity;GO:0030501|positive regulation of bone mineralization;GO:0033280|response to vitamin D;GO:0042421|norepinephrine biosynthetic process;GO:0055074|calcium ion homeostasis;GO:0071774|response to fibroblast growth factor;GO:0090080|positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway;GO:1990776|response to angiotensin;","GO:0005615|extracellular space;GO:0005783|endoplasmic reticulum;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;","GO:0004553|hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0004566|beta-glucuronidase activity;GO:0005104|fibroblast growth factor receptor binding;GO:0008422|beta-glucosidase activity;GO:0017134|fibroblast growth factor binding;","K14756","KL; klotho [EC:3.2.1.31]"]
["ENSRNOG00000008855",4,0.336541075,33,2.12290446,0.158528601,-2.657184945,{"v":9.23707e-06,"d":"9.24E-06"},{"v":9.72625e-06,"d":"9.73E-06"},"down","yes","Gjb2","protein_coding","chr15:31260357-31278177:-","gi|148704234|gb|EDL36181.1|",1403,0,"gap junction membrane channel protein beta 2, isoform CRA_b, partial [Mus musculus]","gi|51871606|ref|NM_001004099.1|",2421,0,"Rattus norvegicus gap junction protein, beta 2 (Gjb2), mRNA","P21994",470,{"v":4E-159,"d":"4.00E-159"},"Gap junction beta-2 protein",".",".",".",".","pfam00029","Connexin","Connexin.","GO:0002931|response to ischemia;GO:0007267|cell-cell signaling;GO:0007565|female pregnancy;GO:0007568|aging;GO:0007605|sensory perception of sound;GO:0010644|cell communication by electrical coupling;GO:0016264|gap junction assembly;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0032526|response to retinoic acid;GO:0032570|response to progesterone;GO:0034599|cellular response to oxidative stress;GO:0044752|response to human chorionic gonadotropin;GO:0046677|response to antibiotic;GO:0046697|decidualization;GO:0048839|inner ear development;GO:0055085|transmembrane transport;GO:0071377|cellular response to glucagon stimulus;GO:0071549|cellular response to dexamethasone stimulus;GO:1905867|epididymis development;GO:1990349|gap junction-mediated intercellular transport;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005921|gap junction;GO:0005922|connexin complex;GO:0016328|lateral plasma membrane;GO:0030054|cell junction;GO:0044297|cell body;GO:0048471|perinuclear region of cytoplasm;GO:0097449|astrocyte projection;","GO:0005243|gap junction channel activity;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0042802|identical protein binding;GO:1903763|gap junction channel activity involved in cell communication by electrical coupling;","K07621","GJB2, CX26; gap junction beta-2 protein"]
["ENSRNOG00000029980",8,0.673082149,44,2.83053928,0.237792902,-2.072222444,{"v":9.91202e-06,"d":"9.91E-06"},{"v":1.03927E-5,"d":"1.04E-05"},"down","yes","Zbtb16","protein_coding","chr8:48994566-49177011:-","gi|61557206|ref|NP_001013199.1|",3523,0,"zinc finger and BTB domain-containing protein 16 [Rattus norvegicus]","gi|55669172|gb|AY781103.1|",2331,0,"Rattus norvegicus strain BN/Cub promyelocytic leukemia zinc finger protein (Zfp145) mRNA, complete cds","Q05516",1308,0,"Zinc finger and BTB domain-containing protein 16",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001501|skeletal system development;GO:0001823|mesonephros development;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007417|central nervous system development;GO:0008285|negative regulation of cell proliferation;GO:0009880|embryonic pattern specification;GO:0009952|anterior/posterior pattern specification;GO:0030097|hemopoiesis;GO:0030326|embryonic limb morphogenesis;GO:0032332|positive regulation of chondrocyte differentiation;GO:0034504|protein localization to nucleus;GO:0035116|embryonic hindlimb morphogenesis;GO:0035136|forelimb morphogenesis;GO:0035137|hindlimb morphogenesis;GO:0042733|embryonic digit morphogenesis;GO:0043065|positive regulation of apoptotic process;GO:0043931|ossification involved in bone maturation;GO:0045600|positive regulation of fat cell differentiation;GO:0045638|negative regulation of myeloid cell differentiation;GO:0045778|positive regulation of ossification;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048133|male germ-line stem cell asymmetric division;GO:0051138|positive regulation of NK T cell differentiation;GO:0051216|cartilage development;GO:0061036|positive regulation of cartilage development;","GO:0005634|nucleus;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016604|nuclear body;GO:0016605|PML body;GO:0016607|nuclear speck;GO:0017053|transcriptional repressor complex;GO:0032991|protein-containing complex;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001222|transcription corepressor binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003690|double-stranded DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0005515|protein binding;GO:0008022|protein C-terminus binding;GO:0019904|protein domain specific binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;","K10055","ZBTB16, PLZF; zinc finger and BTB domain-containing protein 16"]
["ENSRNOG00000008806",10,0.841352686,49,3.152191471,0.2669104,-1.905572575,{"v":1.01466E-5,"d":"1.01E-05"},{"v":1.06305e-05,"d":"1.06E-05"},"down","yes","Clip4","protein_coding","chr6:23616281-23677874:-","gi|62078611|ref|NP_001013964.1|",2363,0,"CAP-Gly domain-containing linker protein 4 [Rattus norvegicus]","gi|62078610|ref|NM_001013942.1|",1444,0,"Rattus norvegicus CAP-GLY domain containing linker protein family, member 4 (Clip4), mRNA","Q66HD5",914,0,"CAP-Gly domain-containing linker protein 4","YPL174c",70.9,{"v":6e-12,"d":"6.00E-12"},"COG5244","pfam01302","CAP_GLY","CAP-Gly domain. Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove.","GO:0031122|cytoplasmic microtubule organization;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0035371|microtubule plus-end;GO:0043231|intracellular membrane-bounded organelle;","GO:0051010|microtubule plus-end binding;","K10423","CLIP3_4; CAP-Gly domain-containing linker protein 3/4"]
["ENSRNOG00000020151",47,3.954357626,125,8.041304773,0.491755721,-1.023986258,{"v":1.01598e-05,"d":"1.02E-05"},{"v":1.06422E-5,"d":"1.06E-05"},"down","yes","Cdh1","protein_coding","chr19:34492371-34561775:+","gi|13786164|ref|NP_112624.1|",3917,0,"cadherin-1 precursor [Rattus norvegicus]","gi|13786163|ref|NM_031334.1|",4097,0,"Rattus norvegicus cadherin 1 (Cdh1), mRNA","Q9R0T4",1513,0,"Cadherin-1",".",".",".",".","pfam01049","Cadherin_C","Cadherin cytoplasmic region. Cadherins are vital in cell-cell adhesion during tissue differentiation. Cadherins are linked to the cytoskeleton by catenins. Catenins bind to the cytoplasmic tail of the cadherin. Cadherins cluster to form foci of homophilic binding units. A key determinant to the strength of the binding that it is mediated by cadherins is the juxtamembrane region of the cadherin. This region induces clustering and also binds to the protein p120ctn.","GO:0001701|in utero embryonic development;GO:0001829|trophectodermal cell differentiation;GO:0003382|epithelial cell morphogenesis;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007416|synapse assembly;GO:0007566|embryo implantation;GO:0007605|sensory perception of sound;GO:0009410|response to xenobiotic stimulus;GO:0009636|response to toxic substance;GO:0010033|response to organic substance;GO:0010468|regulation of gene expression;GO:0010955|negative regulation of protein processing;GO:0016339|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0019538|protein metabolic process;GO:0021983|pituitary gland development;GO:0022408|negative regulation of cell-cell adhesion;GO:0022409|positive regulation of cell-cell adhesion;GO:0030336|negative regulation of cell migration;GO:0031175|neuron projection development;GO:0031532|actin cytoskeleton reorganization;GO:0032880|regulation of protein localization;GO:0033561|regulation of water loss via skin;GO:0034332|adherens junction organization;GO:0035847|uterine epithelium development;GO:0042307|positive regulation of protein import into nucleus;GO:0043281|regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0044331|cell-cell adhesion mediated by cadherin;GO:0045893|positive regulation of transcription, DNA-templated;GO:0046697|decidualization;GO:0050680|negative regulation of epithelial cell proliferation;GO:0060576|intestinal epithelial cell development;GO:0060662|salivary gland cavitation;GO:0060693|regulation of branching involved in salivary gland morphogenesis;GO:0070830|bicellular tight junction assembly;GO:0071230|cellular response to amino acid stimulus;GO:0071285|cellular response to lithium ion;GO:0071681|cellular response to indole-3-methanol;GO:0072659|protein localization to plasma membrane;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0090102|cochlea development;GO:0098609|cell-cell adhesion;GO:0098742|cell-cell adhesion via plasma-membrane adhesion molecules;GO:0099576|regulation of protein catabolic process at postsynapse, modulating synaptic transmission;GO:1903077|negative regulation of protein localization to plasma membrane;GO:2000008|regulation of protein localization to cell surface;GO:2001222|regulation of neuron migration;","GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005802|trans-Golgi network;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0005912|adherens junction;GO:0009898|cytoplasmic side of plasma membrane;GO:0009986|cell surface;GO:0015629|actin cytoskeleton;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016328|lateral plasma membrane;GO:0016342|catenin complex;GO:0016600|flotillin complex;GO:0030027|lamellipodium;GO:0030054|cell junction;GO:0030424|axon;GO:0030864|cortical actin cytoskeleton;GO:0033268|node of Ranvier;GO:0043219|lateral loop;GO:0043220|Schmidt-Lanterman incisure;GO:0043296|apical junction complex;GO:0043679|axon terminus;GO:0045177|apical part of cell;GO:0048471|perinuclear region of cytoplasm;GO:0071944|cell periphery;GO:0098794|postsynapse;GO:0098978|glutamatergic synapse;","GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0008013|beta-catenin binding;GO:0008092|cytoskeletal protein binding;GO:0019903|protein phosphatase binding;GO:0019904|protein domain specific binding;GO:0030506|ankyrin binding;GO:0032794|GTPase activating protein binding;GO:0042802|identical protein binding;GO:0045294|alpha-catenin binding;GO:0045295|gamma-catenin binding;GO:0045296|cadherin binding;GO:0050839|cell adhesion molecule binding;","K05689","CDH1, CDHE, CD324; cadherin 1, type 1, E-cadherin"]
["ENSRNOG00000017420",46,3.870222358,123,7.912643897,0.48911873299999997,-1.031743375,{"v":1.05524e-05,"d":"1.06E-05"},{"v":1.10217E-5,"d":"1.10E-05"},"down","yes","Nudt6","protein_coding","chr2:120290847-120306230:-","gi|31077146|ref|NP_852028.1|",1269,{"v":5e-172,"d":"5.00E-172"},"nucleoside diphosphate-linked moiety X motif 6 precursor [Rattus norvegicus]","gi|31343426|ref|NM_181363.2|",1006,0,"Rattus norvegicus nudix hydrolase 6 (Nudt6), mRNA","P70563",493,{"v":2e-173,"d":"2.00E-173"},"Nucleoside diphosphate-linked moiety X motif 6","BS_yjhB",53.1,1e-07,"COG1051","pfam00293","NUDIX","NUDIX domain.","GO:0008285|negative regulation of cell proliferation;GO:0045786|negative regulation of cell cycle;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;","GO:0035529|NADH pyrophosphatase activity;GO:0047631|ADP-ribose diphosphatase activity;GO:0051287|NAD binding;",".","."]
["ENSRNOG00000010079",32,2.692328597,96,6.175722066,0.435953653,-1.197753326,{"v":1.13251e-05,"d":"1.13E-05"},{"v":1.17881E-5,"d":"1.18E-05"},"down","yes","Ca3","protein_coding","chr2:86770420-86784280:-","gi|31377484|ref|NP_062165.2|",1401,0,"carbonic anhydrase 3 [Rattus norvegicus]","gi|564335771|ref|XM_006232116.1|",1870,0,"PREDICTED: Rattus norvegicus carbonic anhydrase 3 (Car3), transcript variant X1, mRNA","P14141",544,0,"Carbonic anhydrase 3","all2929",128,{"v":4e-32,"d":"4.00E-32"},"COG3338","pfam00194","Carb_anhydrase","Eukaryotic-type carbonic anhydrase.","GO:0006730|one-carbon metabolic process;GO:0006979|response to oxidative stress;GO:0009617|response to bacterium;GO:0016311|dephosphorylation;GO:0045471|response to ethanol;","GO:0005829|cytosol;","GO:0004089|carbonate dehydratase activity;GO:0008270|zinc ion binding;GO:0016151|nickel cation binding;GO:0016791|phosphatase activity;GO:0016836|hydro-lyase activity;","K01672","CA; carbonic anhydrase [EC:4.2.1.1]"]
["ENSRNOG00000067358",44,3.70195182,119,7.655322144,0.483578842,-1.04817697,{"v":1.13451e-05,"d":"1.13E-05"},{"v":1.18043E-5,"d":"1.18E-05"},"down","yes","ENSRNOG00000067358","lncRNA","chr5:73856000-73864390:+","gi|149037114|gb|EDL91645.1|",431,{"v":1e-45,"d":"1.00E-45"},"guanine nucleotide binding protein (G protein), gamma 10 [Rattus norvegicus]","gi|399154111|ref|NM_053660.2|",817,0,"Rattus norvegicus guanine nucleotide binding protein (G protein), gamma 10 (Gng10), mRNA","Q9CXP8",90.1,{"v":3e-19,"d":"3.00E-19"},"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10",".",".",".",".","pfam00631","G-gamma","GGL domain. G-protein gamma like domains (GGL) are found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling (RGS) proteins. It is also found fused to an inactive Galpha in the Dictyostelium protein gbqA. G-gamma likely shares a common origin with the helical N-terminal unit of G-beta. All organisms that posses a G-beta possess a G-gamma.",".",".",".",".","."]
["ENSRNOG00000011310",29,2.439922791,90,5.789739437,0.421421865,-1.246662926,{"v":1.14913E-5,"d":"1.15E-05"},{"v":1.19473E-5,"d":"1.19E-05"},"down","yes","Pde10a","protein_coding","chr1:51770132-52216563:-","gi|42600933|gb|AAS21243.1|",4505,0,"PDE10A11 [Rattus norvegicus]","gi|13489074|ref|NM_022236.1|",3042,0,"Rattus norvegicus phosphodiesterase 10A (Pde10a), mRNA","Q8CA95",1616,0,"cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A",".",".",".",".","pfam00233","PDEase_I","3'5'-cyclic nucleotide phosphodiesterase.","GO:0006198|cAMP catabolic process;GO:0007165|signal transduction;GO:0010738|regulation of protein kinase A signaling;GO:0010754|negative regulation of cGMP-mediated signaling;GO:0043951|negative regulation of cAMP-mediated signaling;GO:0046069|cGMP catabolic process;GO:0106070|regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway;","GO:0005737|cytoplasm;GO:0016020|membrane;GO:0043025|neuronal cell body;GO:0043204|perikaryon;","GO:0004112|cyclic-nucleotide phosphodiesterase activity;GO:0004114|3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0004115|3',5'-cyclic-AMP phosphodiesterase activity;GO:0004118|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity;GO:0030552|cAMP binding;GO:0030553|cGMP binding;GO:0046872|metal ion binding;GO:0047555|3',5'-cyclic-GMP phosphodiesterase activity;","K18438","PDE10; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10 [EC:3.1.4.17 3.1.4.35]"]
["ENSRNOG00000037100",2,0.168270537,26,1.672591393,0.100604689,-3.313230543,{"v":1.18469E-5,"d":"1.18E-05"},{"v":1.22983E-5,"d":"1.23E-05"},"down","yes","Heatr9","protein_coding","chr10:68308579-68319376:-","gi|564313077|ref|XP_006220813.1|",2934,0,"PREDICTED: protein HEATR9 isoform X1 [Rattus norvegicus]","gi|672025031|ref|XM_006220751.2|",2435,0,"PREDICTED: Rattus norvegicus HEAT repeat containing 9 (Heatr9), transcript variant X1, mRNA","Q5QNV8",890,0,"Protein HEATR9",".",".",".",".","pfam13646","HEAT_2","HEAT repeats. This family includes multiple HEAT repeats.","GO:0002244|hematopoietic progenitor cell differentiation;",".",".",".","."]
["ENSRNOG00000012815",18,1.514434836,67,4.310139358,0.351365631,-1.508955014,{"v":1.19785e-05,"d":"1.20E-05"},{"v":1.24278E-5,"d":"1.24E-05"},"down","yes","Chst10","protein_coding","chr9:41092808-41122503:-","gi|564367902|ref|XP_006244792.1|",1971,0,"PREDICTED: carbohydrate sulfotransferase 10 isoform X2 [Rattus norvegicus]","gi|672064775|ref|XM_008766987.1|",2405,0,"PREDICTED: Rattus norvegicus carbohydrate sulfotransferase 10 (Chst10), transcript variant X4, mRNA","O54702",739,0,"Carbohydrate sulfotransferase 10",".",".",".",".","pfam03567","Sulfotransfer_2","Sulfotransferase family. This family includes a variety of sulfotransferase enzymes. Chondroitin 6-sulfotransferase catalyses the transfer of sulfate to position 6 of the N-acetylgalactosamine residue of chondroitin. This family also includes Heparan sulfate 2-O-sulfotransferase (HS2ST) and Heparan sulfate 6-sulfotransferase (HS6ST). Heparan sulfate (HS) is a co-receptor for a number of growth factors, morphogens, and adhesion proteins. HS biosynthetic modifications may determine the strength and outcome of HS-ligand interactions. Mice that lack HS2ST undergo developmental failure only after midgestation,the most dramatic effect being the complete failure of kidney development. Heparan sulphate 6- O -sulfotransferase (HS6ST) catalyses the transfer of sulphate from adenosine 3'-phosphate, 5'-phosphosulphate to the 6th position of the N -sulphoglucosamine residue in heparan sulphate.","GO:0007612|learning;GO:0007616|long-term memory;GO:0016051|carbohydrate biosynthetic process;GO:0030166|proteoglycan biosynthetic process;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0008146|sulfotransferase activity;GO:0016232|HNK-1 sulfotransferase activity;","K09674","CHST10; carbohydrate 3-sulfotransferase 10 [EC:2.8.2.-]"]
["ENSRNOG00000039740",39,3.281275477,109,7.012017762,0.467950252,-1.095572931,{"v":1.32843e-05,"d":"1.33E-05"},{"v":1.37237E-5,"d":"1.37E-05"},"down","yes","Cenpk","protein_coding","chr2:35360132-35385706:+","gi|157823361|ref|NP_001099877.1|",1580,0,"centromere protein K [Rattus norvegicus]","gi|157823360|ref|NM_001106407.1|",1641,0,"Rattus norvegicus centromere protein K (Cenpk), mRNA","Q9ESN5",311,{"v":3e-100,"d":"3.00E-100"},"Centromere protein K",".",".",".",".","pfam11802","CENP-K","Centromere-associated protein K. CENP-K is one of seven new CENP-A-nucleosome distal (CAD) centromere components (the others being CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S) that are identified as assembling on the CENP-A nucleosome associated complex, NAC. The CENP-A NAC is essential, as disruption of the complex causes errors of chromosome alignment and segregation that preclude cell survival despite continued centromere-derived mitotic checkpoint signalling. CENP-K is centromere-associated through its interaction with one or more components of the CENP-A NAC.","GO:0000070|mitotic sister chromatid segregation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051382|kinetochore assembly;","GO:0000775|chromosome, centromeric region;GO:0005634|nucleus;",".","K11503","CENPK; centromere protein K"]
["ENSRNOG00000055939",20,1.682705373,71,4.567461111,0.368411538,-1.44060985,{"v":1.33734E-5,"d":"1.34E-05"},{"v":1.37987e-05,"d":"1.38E-05"},"down","yes","Zcchc18","protein_coding","chrX:100319497-100322820:+","gi|564323162|ref|XP_006227544.1|",2112,0,"PREDICTED: zinc finger CCHC domain-containing protein 18 [Rattus norvegicus]","gi|78482620|ref|NM_001035510.1|",2046,0,"Mus musculus zinc finger, CCHC domain containing 18 (Zcchc18), transcript variant 1, mRNA","Q8VD24",702,0,"Zinc finger CCHC domain-containing protein 18",".",".",".",".","pfam14893","PNMA","PNMA. The PNMA family includes paraneoplastic antigens Ma 1, 2 and 3, found in the serum of patients with paraneoplastic neurological disorders. The family also includes modulator of apoptosis 1, which has a role in death receptor-dependent apoptosis.",".",".",".",".","."]
["ENSRNOG00000035606",38,3.197140209,107,6.883356886,0.464473986,-1.106330298,{"v":1.36459e-05,"d":"1.36E-05"},{"v":1.40587E-5,"d":"1.41E-05"},"down","yes","Mir3554","miRNA","chr5:103599032-103599149:+",".",".",".",".","gi|312147245|ref|NR_037332.1|",118,{"v":6e-54,"d":"6.00E-54"},"Rattus norvegicus microRNA 3554 (Mir3554), microRNA",".",".",".",".",".",".",".",".","pfam07817","GLE1","GLE1-like protein. The members of this family are sequences that are similar to the human protein GLE1. This protein is localized at the nuclear pore complexes and functions in poly(A)+ RNA export to the cytoplasm.",".",".",".",".","."]
["ENSRNOG00000014511",15,1.26202903,60,3.859826291,0.32696524,-1.612790825,{"v":1.367E-5,"d":"1.37E-05"},{"v":1.40781E-5,"d":"1.41E-05"},"down","yes","Alg10","protein_coding","chr7:121335042-121340308:+","gi|20806143|ref|NP_620801.1|",2342,0,"putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase [Rattus norvegicus]","gi|158711684|ref|NM_139101.2|",2370,0,"Rattus norvegicus ALG10, alpha-1,2-glucosyltransferase (Alg10), mRNA","O88788",904,0,"Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase",".",".",".",".","pfam04922","DIE2_ALG10","DIE2/ALG10 family. The ALG10 protein from Saccharomyces cerevisiae encodes the alpha-1,2 glucosyltransferase of the endoplasmic reticulum. This protein has been characterized in rat as potassium channel regulator 1.","GO:0006487|protein N-linked glycosylation;GO:0006488|dolichol-linked oligosaccharide biosynthetic process;GO:0007605|sensory perception of sound;GO:0060117|auditory receptor cell development;GO:0071805|potassium ion transmembrane transport;","GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0005515|protein binding;GO:0106073|dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity;","K03850","ALG10; alpha-1,2-glucosyltransferase [EC:2.4.1.256]"]
["ENSRNOG00000053586",1,0.084135269,22,1.41526964,0.059448225,-4.072222444,{"v":1.41145E-5,"d":"1.41E-05"},{"v":1.45029E-5,"d":"1.45E-05"},"down","yes","Snord19","snoRNA","chr16:6210838-6210914:-",".",".",".",".","gi|908663642|tpe|LN872820.1|",64,{"v":4e-24,"d":"4.00E-24"},"TPA: Mus musculus SNORD19 gene for small nucleolar RNA SNORD19",".",".",".",".",".",".",".",".","pfam11360","DUF3110","Protein of unknown function (DUF3110). This family of proteins has no known function.",".",".",".",".","."]
["ENSRNOG00000062880",22,1.85097591,75,4.824782864,0.383639215,-1.382177897,{"v":1.44401e-05,"d":"1.44E-05"},{"v":1.48124e-05,"d":"1.48E-05"},"down","yes","ENSRNOG00000062880","lncRNA","chr2:763810-787844:-",".",".",".",".","gi|564360212|ref|XR_355699.1|",679,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102551151 (LOC102551151), ncRNA",".",".",".",".",".",".",".",".","pfam04247","SirB","Invasion gene expression up-regulator, SirB. SirB up-regulates Salmonella typhimurium invasion gene transcription. It is, however, not essential for the expression of these genes. Its function is unknown.",".",".",".",".","."]
["ENSRNOG00000014874",16,1.346164298,62,3.988487167,0.337512506,-1.566987136,{"v":1.4934E-5,"d":"1.49E-05"},{"v":1.52931e-05,"d":"1.53E-05"},"down","yes","Zfyve28","protein_coding","chr14:76468424-76554039:+","gi|564384371|ref|XP_006251318.1|",4789,0,"PREDICTED: lateral signaling target protein 2 homolog isoform X1 [Rattus norvegicus]","gi|672076706|ref|XM_006251256.2|",3997,0,"PREDICTED: Rattus norvegicus zinc finger, FYVE domain containing 28 (Zfyve28), transcript variant X1, mRNA","Q6ZPK7",1746,0,"Lateral signaling target protein 2 homolog",".",".",".",".","pfam01363","FYVE","FYVE zinc finger. The FYVE zinc finger is named after four proteins that it has been found in: Fab1, YOTB/ZK632.12, Vac1, and EEA1. The FYVE finger has been shown to bind two Zn++ ions. The FYVE finger has eight potential zinc coordinating cysteine positions. Many members of this family also include two histidines in a motif R+HHC+XCG, where + represents a charged residue and X any residue. We have included members which do not conserve these histidine residues but are clearly related.","GO:0007175|negative regulation of epidermal growth factor-activated receptor activity;GO:0042059|negative regulation of epidermal growth factor receptor signaling pathway;","GO:0005829|cytosol;GO:0031901|early endosome membrane;","GO:0032266|phosphatidylinositol-3-phosphate binding;GO:0046872|metal ion binding;","K24780","ZFYVE28, LST2; lateral signaling target protein 2"]
["ENSRNOG00000028543",43,3.617816552,116,7.462330829,0.484810528,-1.044507066,{"v":1.54836e-05,"d":"1.55E-05"},{"v":1.58172e-05,"d":"1.58E-05"},"down","yes","AABR07052523.1","protein_coding","chr3:57576709-57578013:+","gi|158186649|ref|NP_036686.2|",2301,0,"alpha-enolase [Rattus norvegicus]","gi|297207117|ref|NG_021381.1|",1305,0,"Rattus norvegicus enolase 1, (alpha), pseudogene 1 (Eno1-ps1) on chromosome 3","P04764",890,0,"Alpha-enolase","YGR254w",559,0,"COG0148","pfam00113","Enolase_C","Enolase, C-terminal TIM barrel domain.","GO:0006096|glycolytic process;",".","GO:0000287|magnesium ion binding;",".","."]
["ENSRNOG00000021619",29,2.439922791,89,5.725408998,0.426156942,-1.230543261,{"v":1.57294e-05,"d":"1.57E-05"},{"v":1.60446e-05,"d":"1.60E-05"},"down","yes","Cela3b","protein_coding","chr5:149628773-149636937:-","gi|672054392|ref|XP_008762442.1|",1435,0,"PREDICTED: chymotrypsin-like elastase family member 3B isoform X1 [Rattus norvegicus]","gi|672054391|ref|XM_008764220.1|",949,0,"PREDICTED: Rattus norvegicus chymotrypsin-like elastase family, member 3B (Cela3b), transcript variant X1, mRNA","Q9CQ52",473,{"v":3e-167,"d":"3.00E-167"},"Chymotrypsin-like elastase family member 3B","VC1649",85.1,{"v":1e-17,"d":"1.00E-17"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;","GO:0005615|extracellular space;","GO:0004252|serine-type endopeptidase activity;","K01345","CELA3; pancreatic endopeptidase E [EC:3.4.21.70]"]
["ENSRNOG00000014970",28,2.355787522,87,5.596748122,0.420920769,-1.248379399,{"v":1.57492e-05,"d":"1.57E-05"},{"v":1.60615e-05,"d":"1.61E-05"},"down","yes","Kif17","protein_coding","chr5:150481578-150519638:+","gi|564353823|ref|XP_006239352.1|",5123,0,"PREDICTED: kinesin-like protein KIF17 isoform X5 [Rattus norvegicus]","gi|672054702|ref|XM_006239290.2|",3185,0,"PREDICTED: Rattus norvegicus kinesin family member 17 (Kif17), transcript variant X1, mRNA","Q99PW8",1831,0,"Kinesin-like protein KIF17","SPAC1834.07",249,{"v":1e-69,"d":"1.00E-69"},"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0007017|microtubule-based process;GO:0007018|microtubule-based movement;GO:0016192|vesicle-mediated transport;GO:0030030|cell projection organization;GO:0031503|protein-containing complex localization;GO:0098971|anterograde dendritic transport of neurotransmitter receptor complex;","GO:0005815|microtubule organizing center;GO:0005871|kinesin complex;GO:0005874|microtubule;GO:0005929|cilium;GO:0005930|axoneme;GO:0015630|microtubule cytoskeleton;GO:0030992|intraciliary transport particle B;GO:0032391|photoreceptor connecting cilium;GO:0032839|dendrite cytoplasm;GO:0036064|ciliary basal body;GO:0043005|neuron projection;GO:1990075|periciliary membrane compartment;","GO:0003777|microtubule motor activity;GO:0005524|ATP binding;GO:0008017|microtubule binding;GO:0008574|ATP-dependent microtubule motor activity, plus-end-directed;GO:0016887|ATPase activity;","K20198","KIF17; kinesin family member 17"]
["ENSRNOG00000033923",42,3.533681283,114,7.333669953,0.481843512,-1.053363417,{"v":1.60344E-5,"d":"1.60E-05"},{"v":1.63309E-5,"d":"1.63E-05"},"down","yes","Aox2","protein_coding","chr9:59828084-59916146:+","gi|672065175|ref|XP_008765328.1|",6863,0,"PREDICTED: aldehyde oxidase 2 isoform X1 [Rattus norvegicus]","gi|672065174|ref|XM_008767106.1|",4403,0,"PREDICTED: Rattus norvegicus aldehyde oxidase 2 (Aox2), transcript variant X1, mRNA","Q5QE78",2608,0,"Aldehyde oxidase 2","SMb21287",476,{"v":3e-147,"d":"3.00E-147"},"COG4631","pfam02738","Ald_Xan_dh_C2","Molybdopterin-binding domain of aldehyde dehydrogenase.","GO:0006805|xenobiotic metabolic process;","GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004031|aldehyde oxidase activity;GO:0005506|iron ion binding;GO:0016491|oxidoreductase activity;GO:0042803|protein homodimerization activity;GO:0043546|molybdopterin cofactor binding;GO:0050250|retinal oxidase activity;GO:0050660|flavin adenine dinucleotide binding;GO:0051287|NAD binding;GO:0051537|2 iron, 2 sulfur cluster binding;GO:0071949|FAD binding;GO:0102797|geranial:oxygen oxidoreductase activity;GO:0102798|heptaldehyde:oxygen oxidoreductase activity;","K00157","AOX; aldehyde oxidase [EC:1.2.3.1]"]
["ENSRNOG00000060816",17,1.430299567,64,4.117148044,0.347400568,-1.525327984,{"v":1.61044e-05,"d":"1.61E-05"},{"v":1.6396E-5,"d":"1.64E-05"},"down","yes","Gm22988","snoRNA","chr10:54387185-54387327:-",".",".",".",".","gi|755540011|ref|XM_006534485.2|",109,{"v":8e-49,"d":"8.00E-49"},"PREDICTED: Mus musculus Sec24 related gene family, member A (S. cerevisiae) (Sec24a), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam10070","DUF2309","Uncharacterized protein conserved in bacteria (DUF2309). Members of this family of hypothetical bacterial proteins have no known function.",".",".",".",".","."]
["ENSRNOG00000004679",13,1.093758492,55,3.5381741,0.309130772,-1.693710821,{"v":1.61804e-05,"d":"1.62E-05"},{"v":1.64641E-5,"d":"1.65E-05"},"down","yes","Fign","protein_coding","chr3:48642496-48760787:-","gi|157817141|ref|NP_001099954.1|",3512,0,"fidgetin [Rattus norvegicus]","gi|672045768|ref|XM_008761890.1|",3414,0,"PREDICTED: Rattus norvegicus fidgetin (Fign), transcript variant X3, mRNA","Q9ERZ6",1350,0,"Fidgetin","ECU11g1030",279,{"v":3e-82,"d":"3.00E-82"},"COG0464","pfam00004","AAA","ATPase family associated with various cellular activities (AAA). AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.","GO:0007626|locomotory behavior;GO:0051013|microtubule severing;","GO:0016363|nuclear matrix;","GO:0005524|ATP binding;GO:0008022|protein C-terminus binding;GO:0008568|microtubule-severing ATPase activity;",".","."]
["ENSRNOG00000002984",7,0.588946881,40,2.573217527,0.228875668,-2.127363998,{"v":1.83221e-05,"d":"1.83E-05"},{"v":1.85257e-05,"d":"1.85E-05"},"down","yes","Bmp15","protein_coding","chrX:16169123-16174187:+","gi|11067389|ref|NP_067702.1|",2016,0,"bone morphogenetic protein 15 precursor [Rattus norvegicus]","gi|11067388|ref|NM_021670.1|",1435,0,"Rattus norvegicus bone morphogenetic protein 15 (Bmp15), mRNA","Q9Z0L4",686,0,"Bone morphogenetic protein 15",".",".",".",".","pfam00019","TGF_beta","Transforming growth factor beta like domain.","GO:0001541|ovarian follicle development;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0030509|BMP signaling pathway;GO:0045893|positive regulation of transcription, DNA-templated;GO:0060016|granulosa cell development;GO:0060395|SMAD protein signal transduction;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005737|cytoplasm;","GO:0005125|cytokine activity;GO:0008083|growth factor activity;GO:0070698|type I activin receptor binding;","K05498","BMP15, GDF9B; bone morphogenetic protein 15"]
["ENSRNOG00000056151",21,1.766840642,72,4.631791549,0.381459447,-1.390398404,{"v":1.96684E-5,"d":"1.97E-05"},{"v":1.97914e-05,"d":"1.98E-05"},"down","yes","AABR07007642.1","protein_coding","chr2:23117004-23361240:-","gi|16758538|ref|NP_446173.1|",6146,0,"ras-specific guanine nucleotide-releasing factor 2 [Rattus norvegicus]","gi|16758537|ref|NM_053721.1|",3529,0,"Rattus norvegicus RAS protein-specific guanine nucleotide-releasing factor 2 (Rasgrf2), mRNA","Q99JE4",2363,0,"Ras-specific guanine nucleotide-releasing factor 2",".",".",".",".","pfam00617","RasGEF","RasGEF domain. Guanine nucleotide exchange factor for Ras-like small GTPases.",".",".",".",".","."]
["ENSRNOG00000017027",2,0.168270537,25,1.608260955,0.104628877,-3.256647015,{"v":2.01188e-05,"d":"2.01E-05"},{"v":2.01961e-05,"d":"2.02E-05"},"down","yes","Adam2","protein_coding","chr15:40242783-40283952:-","gi|149030319|gb|EDL85375.1|",3744,0,"a disintegrin and metalloprotease domain 2 [Rattus norvegicus]","gi|9910119|ref|NM_020077.1|",2409,0,"Rattus norvegicus ADAM metallopeptidase domain 2 (Adam2), mRNA","Q63202",1439,0,"Disintegrin and metalloproteinase domain-containing protein 2",".",".",".",".","pfam01421","Reprolysin","Reprolysin (M12B) family zinc metalloprotease. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as human ADAM8 and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.","GO:0006508|proteolysis;GO:0007155|cell adhesion;GO:0007229|integrin-mediated signaling pathway;GO:0007283|spermatogenesis;GO:0007338|single fertilization;GO:0007339|binding of sperm to zona pellucida;GO:0008542|visual learning;GO:0008584|male gonad development;GO:0010628|positive regulation of gene expression;GO:0030534|adult behavior;","GO:0001669|acrosomal vesicle;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0032991|protein-containing complex;","GO:0003674|molecular_function;GO:0004222|metalloendopeptidase activity;","K06833","ADAM2; disintegrin and metalloproteinase domain-containing protein 2 [EC:3.4.24.-]"]
["ENSRNOG00000048039",2,0.168270537,25,1.608260955,0.104628877,-3.256647015,{"v":2.01188e-05,"d":"2.01E-05"},{"v":2.01961e-05,"d":"2.02E-05"},"down","yes","ENSRNOG00000048039","protein_coding","chr19:59989-74331:-","gi|155369680|ref|NP_001094469.1|",2977,0,"carboxylesterase 2-like precursor [Rattus norvegicus]","gi|155369679|ref|NM_001100999.1|",1895,0,"Rattus norvegicus similar to carboxylesterase 2 (intestine, liver) (LOC679149), mRNA","Q91WG0",974,0,"Acylcarnitine hydrolase","BS_pnbA",266,{"v":6e-80,"d":"6.00E-80"},"COG2272","pfam00135","COesterase","Carboxylesterase family.",".","GO:0043231|intracellular membrane-bounded organelle;","GO:0052689|carboxylic ester hydrolase activity;","K03927","CES2; carboxylesterase 2 [EC:3.1.1.1 3.1.1.84 3.1.1.56]"]
["ENSRNOG00000054474",43,3.617816552,115,7.398000391,0.489026272,-1.032016122,{"v":2.03715E-5,"d":"2.04E-05"},{"v":2.0431e-05,"d":"2.04E-05"},"down","yes","Mastl","protein_coding","chr17:85251997-85287353:-","gi|157817113|ref|NP_001100839.1|",4171,0,"microtubule-associated serine/threonine-protein kinase-like [Rattus norvegicus]","gi|298898812|emb|FQ224658.1|",3078,0,"Rattus norvegicus TL0ACA59YE19 mRNA sequence","Q8C0P0",1401,0,"Serine/threonine-protein kinase greatwall",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.",".",".",".",".","."]
["ENSRNOG00000006441",24,2.019246448,78,5.017774178,0.402418757,-1.313230543,{"v":2.11086E-5,"d":"2.11E-05"},{"v":2.1139e-05,"d":"2.11E-05"},"down","yes","Zbtb25","protein_coding","chr6:95075331-95095755:-","gi|672056525|ref|XP_008762990.1|",2285,0,"PREDICTED: zinc finger and BTB domain-containing protein 25 isoform X2 [Rattus norvegicus]","gi|672056524|ref|XM_008764768.1|",2664,0,"PREDICTED: Rattus norvegicus zinc finger and BTB domain containing 25 (Zbtb25), transcript variant X1, mRNA","P24278",781,0,"Zinc finger and BTB domain-containing protein 25",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;","GO:0005654|nucleoplasm;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;","K10504","ZBTB25; zinc finger and BTB domain-containing protein 25"]
["ENSRNOG00000051152",25,2.103381716,80,5.146435055,0.40870655,-1.29086273,{"v":2.13684E-5,"d":"2.14E-05"},{"v":2.13875e-05,"d":"2.14E-05"},"down","yes","ENSRNOG00000051152","protein_coding","chr7:7136861-7225513:-","gi|564307957|ref|XP_006225983.1|",696,{"v":1E-87,"d":"1.00E-87"},"PREDICTED: zinc finger protein 431-like isoform X3 [Rattus norvegicus]","gi|672057640|ref|XM_006240825.2|",786,0,"PREDICTED: Rattus norvegicus zinc finger protein 124-like (LOC102549817), transcript variant X4, mRNA","E9QAG8",101,{"v":5e-22,"d":"5.00E-22"},"Zinc finger protein 431",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006355|regulation of transcription, DNA-templated;",".",".",".","."]
["ENSRNOG00000067337",27,2.271652253,84,5.403756808,0.42038388,-1.250220746,{"v":2.15936e-05,"d":"2.16E-05"},{"v":2.1593e-05,"d":"2.16E-05"},"down","yes","ENSRNOG00000067337","lncRNA","chr10:72854687-72859063:+","gi|149035202|gb|EDL89906.1|",175,{"v":4e-12,"d":"4.00E-12"},"rCG56979 [Rattus norvegicus]","gi|755483612|ref|XR_393458.2|",587,0,"PREDICTED: Mus musculus uncharacterized LOC102642420 (LOC102642420), transcript variant X2, ncRNA",".",".",".",".",".",".",".",".","pfam10436","BCDHK_Adom3","Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase. Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal.",".",".",".",".","."]
["ENSRNOG00000021463",16,1.346164298,61,3.924156729,0.343045498,-1.543528163,{"v":2.16131e-05,"d":"2.16E-05"},{"v":2.16046E-5,"d":"2.16E-05"},"down","yes","Ppara","protein_coding","chr7:116832756-116895346:+","gi|564361358|ref|XP_006242213.1|",2383,0,"PREDICTED: peroxisome proliferator-activated receptor alpha isoform X2 [Rattus norvegicus]","gi|6981381|ref|NM_013196.1|",2017,0,"Rattus norvegicus peroxisome proliferator activated receptor alpha (Ppara), mRNA","P37230",885,0,"Peroxisome proliferator-activated receptor alpha",".",".",".",".","pfam00105","zf-C4","Zinc finger, C4 type (two domains). In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001666|response to hypoxia;GO:0006355|regulation of transcription, DNA-templated;GO:0006631|fatty acid metabolic process;GO:0007507|heart development;GO:0008544|epidermis development;GO:0009267|cellular response to starvation;GO:0009755|hormone-mediated signaling pathway;GO:0010468|regulation of gene expression;GO:0010565|regulation of cellular ketone metabolic process;GO:0010745|negative regulation of macrophage derived foam cell differentiation;GO:0010876|lipid localization;GO:0010883|regulation of lipid storage;GO:0010887|negative regulation of cholesterol storage;GO:0010891|negative regulation of sequestering of triglyceride;GO:0014070|response to organic cyclic compound;GO:0019216|regulation of lipid metabolic process;GO:0019217|regulation of fatty acid metabolic process;GO:0030154|cell differentiation;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030522|intracellular receptor signaling pathway;GO:0032091|negative regulation of protein binding;GO:0032099|negative regulation of appetite;GO:0032868|response to insulin;GO:0032922|circadian regulation of gene expression;GO:0033993|response to lipid;GO:0035095|behavioral response to nicotine;GO:0042060|wound healing;GO:0042157|lipoprotein metabolic process;GO:0042752|regulation of circadian rhythm;GO:0043401|steroid hormone mediated signaling pathway;GO:0045070|positive regulation of viral genome replication;GO:0045471|response to ethanol;GO:0045722|positive regulation of gluconeogenesis;GO:0045776|negative regulation of blood pressure;GO:0045820|negative regulation of glycolytic process;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045923|positive regulation of fatty acid metabolic process;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046321|positive regulation of fatty acid oxidation;GO:0046889|positive regulation of lipid biosynthetic process;GO:0050728|negative regulation of inflammatory response;GO:0051898|negative regulation of protein kinase B signaling;GO:0061052|negative regulation of cell growth involved in cardiac muscle cell development;GO:0070166|enamel mineralization;GO:1900016|negative regulation of cytokine production involved in inflammatory response;GO:1901215|negative regulation of neuron death;GO:1902894|negative regulation of pri-miRNA transcription by RNA polymerase II;GO:1903038|negative regulation of leukocyte cell-cell adhesion;GO:1903427|negative regulation of reactive oxygen species biosynthetic process;GO:1903944|negative regulation of hepatocyte apoptotic process;GO:2000272|negative regulation of signaling receptor activity;GO:2001171|positive regulation of ATP biosynthetic process;","GO:0005634|nucleus;GO:0005654|nucleoplasm;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001223|transcription coactivator binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0003707|steroid hormone receptor activity;GO:0004879|nuclear receptor activity;GO:0005515|protein binding;GO:0008270|zinc ion binding;GO:0008289|lipid binding;GO:0019902|phosphatase binding;GO:0019904|protein domain specific binding;GO:0031624|ubiquitin conjugating enzyme binding;GO:0038023|signaling receptor activity;GO:0043565|sequence-specific DNA binding;GO:0044877|protein-containing complex binding;GO:0051525|NFAT protein binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;GO:0097371|MDM2/MDM4 family protein binding;","K07294","NR1C1, PPARA; peroxisome proliferator-activated receptor alpha"]
["ENSRNOG00000031099",17,1.430299567,63,4.052817606,0.352914862,-1.502607908,{"v":2.31544E-5,"d":"2.32E-05"},{"v":2.30648E-5,"d":"2.31E-05"},"down","yes","Tmprss12","protein_coding","chr7:131433484-131445791:+","gi|564309423|ref|XP_003754410.2|",1561,0,"PREDICTED: transmembrane protease serine 12 [Rattus norvegicus]","gi|672022391|ref|XM_003754362.3|",1294,0,"PREDICTED: Rattus norvegicus transmembrane (C-terminal) protease, serine 12 (Tmprss12), mRNA","Q3V0Q7",525,0,"Transmembrane protease serine 12","VC1649",118,{"v":4e-28,"d":"4.00E-28"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0007339|binding of sperm to zona pellucida;GO:0016485|protein processing;","GO:0001669|acrosomal vesicle;","GO:0004252|serine-type endopeptidase activity;",".","."]
["ENSRNOG00000033271",45,3.786087089,118,7.590991706,0.498760536,-1.003580778,{"v":2.46686E-5,"d":"2.47E-05"},{"v":2.44791e-05,"d":"2.45E-05"},"down","yes","AABR07048271.1","protein_coding","chr5:67671721-67680926:+","gi|33086674|gb|AAP92649.1|",769,{"v":5e-102,"d":"5.00E-102"},"Cc2-36 [Rattus norvegicus]","gi|33086673|gb|AY325248.1|",486,0,"Rattus norvegicus Cc2-36 mRNA, complete cds",".",".",".",".",".",".",".",".","pfam03025","Papilloma_E5","Papillomavirus E5. The E5 protein from papillomaviruses is about 80 amino acids long. The proteins are contain three regions that are predicted to be transmembrane alpha helices. The function of this protein is unknown.",".",".",".",".","."]
["ENSRNOG00000009332",4,0.336541075,31,1.994243584,0.168756253,-2.566987136,{"v":2.47195e-05,"d":"2.47E-05"},{"v":2.45207e-05,"d":"2.45E-05"},"down","yes","Rec114","protein_coding","chr8:59063352-59149887:-","gi|564363936|ref|XP_006243219.1|",1361,0,"PREDICTED: meiotic recombination protein REC114 isoform X1 [Rattus norvegicus]","gi|672061886|ref|XM_006243157.2|",984,0,"PREDICTED: Rattus norvegicus REC114 meiotic recombination protein (Rec114), transcript variant X1, mRNA","Q9CWH4",442,{"v":8e-155,"d":"8.00E-155"},"Meiotic recombination protein REC114",".",".",".",".","pfam15165","REC114-like","Meiotic recombination protein REC114-like. REC114-like members are necessary for meiotic DNA double-strand break formation. It functions in conjunction with Mei4. This family of proteins is found in eukaryotes. Proteins in this family are typically between 43 and 259 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000006503",19,1.598570104,67,4.310139358,0.370885944,-1.430952502,{"v":2.57453e-05,"d":"2.57E-05"},{"v":2.54639e-05,"d":"2.55E-05"},"down","yes","Frmd3","protein_coding","chr5:87764604-88031091:+","gi|148699107|gb|EDL31054.1|",2917,0,"FERM domain containing 3, isoform CRA_b, partial [Mus musculus]","gi|254910988|ref|NM_172869.4|",1883,0,"Mus musculus FERM domain containing 3 (Frmd3), transcript variant 1, mRNA","Q8BHD4",1102,0,"FERM domain-containing protein 3",".",".",".",".","pfam00373","FERM_M","FERM central domain. This domain is the central structural domain of the FERM domain.","GO:0031032|actomyosin structure organization;","GO:0005856|cytoskeleton;GO:0016021|integral component of membrane;",".","K23969","FRMD3_5; FERM domain-containing protein 3/5"]
["ENSRNOG00000061186",20,1.682705373,69,4.438800235,0.379090133,-1.399387187,{"v":2.67841E-5,"d":"2.68E-05"},{"v":2.64051e-05,"d":"2.64E-05"},"down","yes","Snord123","snoRNA","chr2:83306918-83306987:-",".",".",".",".","gi|332634882|ref|NR_028575.2|",67,{"v":7e-26,"d":"7.00E-26"},"Mus musculus small nucleolar RNA, C/D box 123 (Snord123), small nucleolar RNA",".",".",".",".",".",".",".",".","pfam14307","Glyco_tran_WbsX","Glycosyltransferase WbsX. Members of this family are found in within O-antigen biosynthesis clusters in Gram negative bacteria, where they are predicted to function as glycosyltransferases.",".",".",".",".","."]
["ENSRNOG00000011094",21,1.766840642,71,4.567461111,0.386832115,-1.370220522,{"v":2.76516e-05,"d":"2.77E-05"},{"v":2.72258e-05,"d":"2.72E-05"},"down","yes","ENSRNOG00000011094","protein_coding","chr7:115019010-115206092:-","gi|564309098|ref|XP_006226240.1|",7883,0,"PREDICTED: EF-hand calcium-binding domain-containing protein 6 isoform X1 [Rattus norvegicus]","gi|672060427|ref|XM_008765815.1|",4262,0,"PREDICTED: Rattus norvegicus EF-hand calcium binding domain 6 (Efcab6), transcript variant X11, mRNA","Q6P1E8",2645,0,"EF-hand calcium-binding domain-containing protein 6",".",".",".",".","pfam08976","DUF1880","Domain of unknown function (DUF1880). This domain is found predominantly in DJ binding protein. It has no known function.",".","GO:0005654|nucleoplasm;","GO:0005509|calcium ion binding;","K23851","EFCAB6; EF-hand calcium-binding domain-containing protein 6"]
["ENSRNOG00000007441",41,3.449546015,110,7.0763482,0.487475449,-1.036598534,{"v":2.88569e-05,"d":"2.89E-05"},{"v":2.8351E-5,"d":"2.84E-05"},"down","yes","Klhl32","protein_coding","chr5:38325543-38568650:-","gi|109474690|ref|XP_232840.4|",3317,0,"PREDICTED: kelch-like protein 32 [Rattus norvegicus]","gi|672019181|ref|XM_001055962.5|",1770,0,"PREDICTED: Rattus norvegicus kelch-like family member 32 (Klhl32), mRNA","Q96NJ5",1243,0,"Kelch-like protein 32",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.",".",".",".","K10468","KLHL32; kelch-like protein 32"]
["ENSRNOG00000020655",9,0.757217418,44,2.83053928,0.267517015,-1.902297442,{"v":2.94158E-5,"d":"2.94E-05"},{"v":2.88481e-05,"d":"2.88E-05"},"down","yes","Ucn2","protein_coding","chr8:109638285-109639172:+","gi|254675174|ref|NP_596876.2|",360,{"v":3e-39,"d":"3.00E-39"},"urocortin-2 precursor [Rattus norvegicus]","gi|254675173|ref|NM_133385.2|",882,0,"Rattus norvegicus urocortin 2 (Ucn2), mRNA","Q91WW1",141,{"v":6e-40,"d":"6.00E-40"},"Urocortin-2",".",".",".",".","pfam11613","UCN2","Agonist of corticotropin releasing factor R2, Urocortin-2. This family of proteins represents urocortin 2, a member of the corticoliberin family which is a selective agnonist of corticotropin releasing factor 2. The backbone of the protein is mainly alpha-helical but it contains a helix-loop-helix motif.","GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007586|digestion;GO:0008283|cell proliferation;GO:0009755|hormone-mediated signaling pathway;GO:0010629|negative regulation of gene expression;GO:0031669|cellular response to nutrient levels;GO:0033685|negative regulation of luteinizing hormone secretion;GO:0035902|response to immobilization stress;GO:0042246|tissue regeneration;GO:0046882|negative regulation of follicle-stimulating hormone secretion;GO:0071385|cellular response to glucocorticoid stimulus;GO:0071456|cellular response to hypoxia;","GO:0005615|extracellular space;","GO:0001664|G protein-coupled receptor binding;GO:0005179|hormone activity;GO:0042562|hormone binding;GO:0051429|corticotropin-releasing hormone receptor binding;GO:0051431|corticotropin-releasing hormone receptor 2 binding;","K05257","UCN2_3; urocortin 2/3"]
["ENSRNOG00000037798",9,0.757217418,44,2.83053928,0.267517015,-1.902297442,{"v":2.94158E-5,"d":"2.94E-05"},{"v":2.88481e-05,"d":"2.88E-05"},"down","yes","Erich4","protein_coding","chr1:81123556-81125296:-","gi|157822377|ref|NP_001102923.1|",633,{"v":3E-79,"d":"3.00E-79"},"glutamate-rich protein 4 [Rattus norvegicus]","gi|157822376|ref|NM_001109453.1|",937,0,"Rattus norvegicus glutamate-rich 4 (Erich4), mRNA",".",".",".",".",".",".",".",".","pfam15039","DUF4530","Domain of unknown function (DUF4530). This family of proteins is found in eukaryotes. Proteins in this family are typically around 140 amino acids in length. The human member of this family is C19orf69.",".",".",".",".","."]
["ENSRNOG00000058842",26,2.187516985,81,5.210765493,0.419807222,-1.25220111,{"v":2.96194E-5,"d":"2.96E-05"},{"v":2.90373e-05,"d":"2.90E-05"},"down","yes","Sptbn2","protein_coding","chr1:202002970-202044283:+","gi|924442952|ref|NP_062040.2|",10208,0,"spectrin beta chain, non-erythrocytic 2 [Rattus norvegicus]","gi|924442951|ref|NM_019167.2|",6840,0,"Rattus norvegicus spectrin, beta, non-erythrocytic 2 (Sptbn2), mRNA","Q9QWN8",3934,0,"Spectrin beta chain, non-erythrocytic 2","SPAC15A10.08",254,{"v":5e-70,"d":"5.00E-70"},"COG5069","pfam00307","CH","Calponin homology (CH) domain. The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.","GO:0007010|cytoskeleton organization;GO:0007416|synapse assembly;GO:0016079|synaptic vesicle exocytosis;GO:0016081|synaptic vesicle docking;GO:0016192|vesicle-mediated transport;GO:0017158|regulation of calcium ion-dependent exocytosis;GO:0021692|cerebellar Purkinje cell layer morphogenesis;GO:0030036|actin cytoskeleton organization;GO:0030534|adult behavior;GO:0035264|multicellular organism growth;GO:0051693|actin filament capping;GO:0071361|cellular response to ethanol;GO:0099173|postsynapse organization;","GO:0000139|Golgi membrane;GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0008021|synaptic vesicle;GO:0008091|spectrin;GO:0016324|apical plasma membrane;GO:0016363|nuclear matrix;GO:0030054|cell junction;GO:0030864|cortical actin cytoskeleton;GO:0042995|cell projection;GO:0043025|neuronal cell body;GO:0048471|perinuclear region of cytoplasm;GO:0098688|parallel fiber to Purkinje cell synapse;GO:0098793|presynapse;GO:0098978|glutamatergic synapse;GO:0099189|postsynaptic spectrin-associated cytoskeleton;","GO:0003779|actin binding;GO:0005200|structural constituent of cytoskeleton;GO:0005515|protein binding;GO:0005543|phospholipid binding;GO:0051015|actin filament binding;GO:0098918|structural constituent of synapse;","K23932","SPTBN2; spectrin beta, non-erythrocytic 2"]
["ENSRNOG00000000017",39,3.281275477,106,6.819026448,0.481194127,-1.055309061,{"v":3.09809E-5,"d":"3.10E-05"},{"v":3.02793E-5,"d":"3.03E-05"},"down","yes","Steap1","protein_coding","chr4:28276909-28287479:+","gi|157817514|ref|NP_001100099.1|",1712,0,"metalloreductase STEAP1 [Rattus norvegicus]","gi|157817513|ref|NM_001106629.1|",1195,0,"Rattus norvegicus six transmembrane epithelial antigen of the prostate 1 (Steap1), mRNA","Q9CWR7",622,0,"Metalloreductase STEAP1",".",".",".",".","pfam01794","Ferric_reduct","Ferric reductase like transmembrane component. This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane. The Frp1 protein from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake. Cytochrome B-245 heavy chain is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterized by the absence of a functional plasma membrane associated NADPH oxidase. The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease.",".","GO:0005768|endosome;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;",".","K14737","STEAP1; metalloreductase STEAP1 [EC:1.16.1.-]"]
["ENSRNOG00000002723",17,1.430299567,62,3.988487167,0.358607037,-1.479524294,{"v":3.31857e-05,"d":"3.32E-05"},{"v":3.23356e-05,"d":"3.23E-05"},"down","yes","Sele","protein_coding","chr13:76403304-76412741:+","gi|149058209|gb|EDM09366.1|",2835,0,"selectin, endothelial cell, isoform CRA_b [Rattus norvegicus]","gi|20302052|ref|NM_138879.1|",3273,0,"Rattus norvegicus selectin E (Sele), mRNA","P98105",1096,0,"E-selectin",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0002092|positive regulation of receptor internalization;GO:0002687|positive regulation of leukocyte migration;GO:0006954|inflammatory response;GO:0007155|cell adhesion;GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007159|leukocyte cell-cell adhesion;GO:0007202|activation of phospholipase C activity;GO:0030029|actin filament-based process;GO:0034097|response to cytokine;GO:0050900|leukocyte migration;GO:0050901|leukocyte tethering or rolling;GO:0070555|response to interleukin-1;GO:1903238|positive regulation of leukocyte tethering or rolling;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005887|integral component of plasma membrane;GO:0005901|caveola;GO:0005905|clathrin-coated pit;GO:0009897|external side of plasma membrane;GO:0030863|cortical cytoskeleton;GO:0045121|membrane raft;GO:0048471|perinuclear region of cytoplasm;","GO:0003674|molecular_function;GO:0004888|transmembrane signaling receptor activity;GO:0033691|sialic acid binding;GO:0043274|phospholipase binding;GO:0046872|metal ion binding;GO:0070492|oligosaccharide binding;","K06494","SELE, CD62E; selectin, endothelial cell"]
["ENSRNOG00000005957",17,1.430299567,62,3.988487167,0.358607037,-1.479524294,{"v":3.31857e-05,"d":"3.32E-05"},{"v":3.23356e-05,"d":"3.23E-05"},"down","yes","Slc4a7","protein_coding","chr15:10588979-10664781:-","gi|399498524|ref|NP_001257789.1|",5422,0,"sodium bicarbonate cotransporter 3 isoform 2 [Rattus norvegicus]","gi|399498523|ref|NM_001270860.1|",3620,0,"Rattus norvegicus solute carrier family 4 member 7 (Slc4a7), transcript variant 2, mRNA","Q9R1N3",2080,0,"Sodium bicarbonate cotransporter 3",".",".",".",".","pfam00955","HCO3_cotransp","HCO3- transporter family. This family contains Band 3 anion exchange proteins that exchange CL-/HCO3-. This family also includes cotransporters of Na+/HCO3-.","GO:0007601|visual perception;GO:0015698|inorganic anion transport;GO:0015701|bicarbonate transport;GO:0021747|cochlear nucleus development;GO:0035725|sodium ion transmembrane transport;GO:0046666|retinal cell programmed cell death;GO:0050801|ion homeostasis;GO:0051453|regulation of intracellular pH;GO:0055085|transmembrane transport;GO:0060117|auditory receptor cell development;GO:0060219|camera-type eye photoreceptor cell differentiation;GO:0061299|retina vasculature morphogenesis in camera-type eye;GO:0098656|anion transmembrane transport;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0031410|cytoplasmic vesicle;GO:0032420|stereocilium;GO:0045202|synapse;","GO:0005452|inorganic anion exchanger activity;GO:0008510|sodium:bicarbonate symporter activity;GO:0022857|transmembrane transporter activity;","K13858","SLC4A7, NBC3; solute carrier family 4 (sodium bicarbonate cotransporter), member 7"]
["ENSRNOG00000069015",6,0.504811612,36,2.315895775,0.217976827,-2.197753326,{"v":3.352e-05,"d":"3.35E-05"},{"v":3.26321e-05,"d":"3.26E-05"},"down","yes","ENSRNOG00000069015","lncRNA","chr12:5872497-5884750:-",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","pfam12439","GDE_N","Glycogen debranching enzyme N terminal. This domain family is found in bacteria and archaea, and is typically between 218 and 229 amino acids in length. The family is found in association with pfam06202. Glycogen debranching enzyme catalyses the debranching of amylopectin in glycogen. This is done by transferring three glucose subunits of glycogen from one parallel chain to another. This has the effect of enabling the glucose residues to become more accessible for glycolysis.",".",".",".",".","."]
["ENSRNOG00000003614",30,2.524058059,88,5.66107856,0.445861691,-1.165331848,{"v":3.91311e-05,"d":"3.91E-05"},{"v":3.76769e-05,"d":"3.77E-05"},"down","yes","Mgat5","protein_coding","chr13:38676119-38959513:+","gi|12831213|ref|NP_075583.1|",3771,0,"alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A [Rattus norvegicus]","gi|12831212|ref|NM_023095.1|",2516,0,"Rattus norvegicus mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase (Mgat5), mRNA","Q08834",1457,0,"Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A",".",".",".",".","pfam15024","Glyco_transf_18","Glycosyltransferase family 18. Enzymes belonging to glycosyltransferase family 18 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase) contribute to the creation of branches in complex-type N-glycans. This domain is responsible for the catalytic activity of the enzyme.","GO:0006487|protein N-linked glycosylation;GO:0018279|protein N-linked glycosylation via asparagine;GO:0030335|positive regulation of cell migration;GO:1903614|negative regulation of protein tyrosine phosphatase activity;GO:1904894|positive regulation of STAT cascade;","GO:0000139|Golgi membrane;GO:0005576|extracellular region;GO:0005794|Golgi apparatus;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0004864|protein phosphatase inhibitor activity;GO:0008375|acetylglucosaminyltransferase activity;GO:0016757|transferase activity, transferring glycosyl groups;GO:0030144|alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity;GO:0030145|manganese ion binding;","K00744","MGAT5; alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetyl-glucosaminyltransferase [EC:2.4.1.155]"]
["ENSRNOG00000069092",40,3.365410746,107,6.883356886,0.488919985,-1.032329717,{"v":3.94065e-05,"d":"3.94E-05"},{"v":3.79219E-5,"d":"3.79E-05"},"down","yes","ENSRNOG00000069092","lncRNA","chr2:57567962-57569697:-",".",".",".",".","gi|55778415|gb|BC086541.1|",943,0,"Rattus norvegicus cDNA clone IMAGE:7123062",".",".",".",".",".",".",".",".","pfam05695","DUF825","Plant protein of unknown function (DUF825). This family consists of several plant proteins greater than 1000 residues in length. The function of this family is unknown.",".",".",".",".","."]
["ENSRNOG00000015403",4,0.336541075,30,1.929913146,0.174381461,-2.519681421,{"v":4.02865e-05,"d":"4.03E-05"},{"v":3.87414e-05,"d":"3.87E-05"},"down","yes","Cd52","protein_coding","chr5:146319969-146321348:-","gi|149024204|gb|EDL80701.1|",210,{"v":1e-19,"d":"1.00E-19"},"CD52 antigen [Rattus norvegicus]","gi|158937237|ref|NM_013706.2|",141,{"v":3e-66,"d":"3.00E-66"},"Mus musculus CD52 antigen (Cd52), mRNA","Q63064",82.8,{"v":5e-20,"d":"5.00E-20"},"CAMPATH-1 antigen",".",".",".",".","pfam15116","CD52","CAMPATH-1 antigen.","GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0009617|response to bacterium;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0031225|anchored component of membrane;GO:0097225|sperm midpiece;",".","K06488","CD52; CDW52 antigen"]
["ENSRNOG00000020908",27,2.271652253,82,5.275095931,0.430637145,-1.215455328,{"v":4.04631e-05,"d":"4.05E-05"},{"v":3.89043E-5,"d":"3.89E-05"},"down","yes","Hrob","protein_coding","chr10:87206049-87222483:+","gi|564374252|ref|XP_006247391.1|",2921,0,"PREDICTED: uncharacterized protein C17orf53 homolog isoform X1 [Rattus norvegicus]","gi|672068707|ref|XM_006247329.2|",2719,0,"PREDICTED: Rattus norvegicus E2F1-inducible gene (LOC303566), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam15072","DUF4539","Domain of unknown function (DUF4539). This family of proteins is found in eukaryotes. Proteins in this family are typically between 230 and 625 amino acids in length.","GO:0000725|recombinational repair;GO:0000731|DNA synthesis involved in DNA repair;GO:0006974|cellular response to DNA damage stimulus;GO:0007292|female gamete generation;GO:0036297|interstrand cross-link repair;GO:0048232|male gamete generation;","GO:0005634|nucleus;GO:0090734|site of DNA damage;","GO:0003697|single-stranded DNA binding;",".","."]
["ENSRNOG00000020873",15,1.26202903,57,3.666834977,0.344173937,-1.538790244,{"v":4.1913e-05,"d":"4.19E-05"},{"v":4.02134e-05,"d":"4.02E-05"},"down","yes","Nphs1","protein_coding","chr1:85720812-85749078:+","gi|12018318|ref|NP_072150.1|",5372,0,"nephrin precursor [Rattus norvegicus]","gi|12018317|ref|NM_022628.1|",3538,0,"Rattus norvegicus NPHS1 nephrin (Nphs1), mRNA","Q9R044",2069,0,"Nephrin",".",".",".",".","pfam08205","C2-set_2","CD80-like C2-set immunoglobulin domain. These domains belong to the immunoglobulin superfamily.","GO:0000165|MAPK cascade;GO:0003094|glomerular filtration;GO:0007155|cell adhesion;GO:0007254|JNK cascade;GO:0007519|skeletal muscle tissue development;GO:0007520|myoblast fusion;GO:0030838|positive regulation of actin filament polymerization;GO:0032836|glomerular basement membrane development;GO:0035418|protein localization to synapse;GO:0044062|regulation of excretion;GO:0072015|glomerular visceral epithelial cell development;GO:0098609|cell-cell adhesion;","GO:0005604|basement membrane;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005911|cell-cell junction;GO:0005925|focal adhesion;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0032991|protein-containing complex;GO:0036057|slit diaphragm;GO:0042995|cell projection;GO:0045121|membrane raft;","GO:0005515|protein binding;GO:0017022|myosin binding;GO:0019904|protein domain specific binding;GO:0030507|spectrin binding;GO:0050839|cell adhesion molecule binding;GO:0051393|alpha-actinin binding;","K24496","NPHS1; nephron"]
["ENSRNOG00000015682",1,0.084135269,20,1.286608764,0.065393048,-3.93471892,{"v":4.19132e-05,"d":"4.19E-05"},{"v":4.02134e-05,"d":"4.02E-05"},"down","yes","Kel","protein_coding","chr4:70568243-70585631:-","gi|300798081|ref|NP_001178540.1|",3626,0,"kell blood group glycoprotein [Rattus norvegicus]","gi|672049507|ref|XM_006236377.2|",2456,0,"PREDICTED: Rattus norvegicus Kell blood group, metallo-endopeptidase (Kel), transcript variant X1, mRNA","Q9EQF2",1257,0,"Kell blood group glycoprotein homolog","MA2001",208,{"v":2e-56,"d":"2.00E-56"},"COG3590","pfam05649","Peptidase_M13_N","Peptidase family M13. M13 peptidases are well-studied proteases found in a wide range of organisms including mammals and bacteria. In mammals they participate in processes such as cardiovascular development, blood-pressure regulation, nervous control of respiration, and regulation of the function of neuropeptides in the central nervous system. In bacteria they may be used for digestion of milk.","GO:0006874|cellular calcium ion homeostasis;GO:0008361|regulation of cell size;GO:0010961|cellular magnesium ion homeostasis;GO:0016485|protein processing;GO:0031133|regulation of axon diameter;GO:0042552|myelination;GO:0048741|skeletal muscle fiber development;GO:1901380|negative regulation of potassium ion transmembrane transport;","GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0004222|metalloendopeptidase activity;GO:0008237|metallopeptidase activity;GO:0046872|metal ion binding;","K06577","KEL, CD238; Kell blood group glycoprotein [EC:3.4.24.-]"]
["ENSRNOG00000011250",0,0.042067634,18,1.157947887,0.036329471,-4.782715827,{"v":4.53369e-05,"d":"4.53E-05"},{"v":4.32771e-05,"d":"4.33E-05"},"down","yes","Inmt","protein_coding","chr4:84318197-84322493:-","gi|157816899|ref|NP_001102492.1|",1260,{"v":9e-172,"d":"9.00E-172"},"indolethylamine N-methyltransferase [Rattus norvegicus]","gi|157816898|ref|NM_001109022.1|",1062,0,"Rattus norvegicus indolethylamine N-methyltransferase (Inmt), mRNA","P40936",461,{"v":8e-162,"d":"8.00E-162"},"Indolethylamine N-methyltransferase",".",".",".",".","pfam01234","NNMT_PNMT_TEMT","NNMT/PNMT/TEMT family.","GO:0009308|amine metabolic process;GO:0032259|methylation;","GO:0005829|cytosol;","GO:0004790|thioether S-methyltransferase activity;GO:0008170|N-methyltransferase activity;GO:0030748|amine N-methyltransferase activity;","K00562","INMT, TEMT; methyltransferase [EC:2.1.1.49 2.1.1.96]"]
["ENSRNOG00000029841",0,0.042067634,18,1.157947887,0.036329471,-4.782715827,{"v":4.53369e-05,"d":"4.53E-05"},{"v":4.32771e-05,"d":"4.33E-05"},"down","yes","Cdh19","protein_coding","chr13:27936668-28019310:-","gi|57222296|ref|NP_001009448.1|",3818,0,"cadherin-19 precursor [Rattus norvegicus]","gi|672073793|ref|XM_006249653.2|",1754,0,"PREDICTED: Rattus norvegicus cadherin 19, type 2 (Cdh19), transcript variant X1, mRNA","Q9H159",1132,0,"Cadherin-19",".",".",".",".","pfam01049","Cadherin_C","Cadherin cytoplasmic region. Cadherins are vital in cell-cell adhesion during tissue differentiation. Cadherins are linked to the cytoskeleton by catenins. Catenins bind to the cytoplasmic tail of the cadherin. Cadherins cluster to form foci of homophilic binding units. A key determinant to the strength of the binding that it is mediated by cadherins is the juxtamembrane region of the cadherin. This region induces clustering and also binds to the protein p120ctn.","GO:0000902|cell morphogenesis;GO:0007043|cell-cell junction assembly;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007275|multicellular organism development;GO:0016339|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0034332|adherens junction organization;GO:0098742|cell-cell adhesion via plasma-membrane adhesion molecules;","GO:0005912|adherens junction;GO:0016021|integral component of membrane;GO:0016342|catenin complex;","GO:0005509|calcium ion binding;GO:0045296|cadherin binding;","K06806","CDH19; cadherin 19, type 2"]
["ENSRNOG00000063221",0,0.042067634,18,1.157947887,0.036329471,-4.782715827,{"v":4.53369e-05,"d":"4.53E-05"},{"v":4.32771e-05,"d":"4.33E-05"},"down","yes","Ncoa4","protein_coding","chr16:7366542-7409641:+","gi|564387996|ref|XP_006252722.1|",3153,0,"PREDICTED: nuclear receptor coactivator 4 isoform X1 [Rattus norvegicus]","gi|77628144|ref|NM_001034008.1|",3325,0,"Rattus norvegicus nuclear receptor coactivator 4 (Ncoa4), transcript variant 2, mRNA","Q13772",903,0,"Nuclear receptor coactivator 4",".",".",".",".","pfam12489","ARA70","Nuclear coactivator. This domain family is found in eukaryotes, and is typically between 127 and 138 amino acids in length. This family is ARA70, a nuclear coactivator which interacts with peroxisome proliferator-activated receptor gamma (PPARgamma) to regulate transcription and the addition of the PPARgamma ligand (prostaglandin J2) enhances this interaction.",".",".",".",".","."]
["ENSRNOG00000013944",35,2.944734403,97,6.240052504,0.471908594,-1.083420651,{"v":4.66861E-5,"d":"4.67E-05"},{"v":4.44792e-05,"d":"4.45E-05"},"down","yes","Zc3hav1l","protein_coding","chr4:66994199-67001620:-","gi|564303548|ref|XP_001069306.3|",1571,0,"PREDICTED: zinc finger CCCH-type antiviral protein 1-like [Rattus norvegicus]","gi|672049402|ref|XM_342661.6|",2671,0,"PREDICTED: Rattus norvegicus zinc finger CCCH-type, antiviral 1-like (Zc3hav1l), mRNA","Q8BFR1",516,{"v":2E-175,"d":"2.00E-175"},"Zinc finger CCCH-type antiviral protein 1-like",".",".",".",".","pfam05624","LSR","Lipolysis stimulated receptor (LSR). The lipolysis-stimulated receptor (LSR) is a lipoprotein receptor primarily expressed in the liver and activated by free fatty acids. It is thought to be involved in the clearance of triglyceride-rich lipoproteins, and has been shown in mice to be critical for liver and embryonic development.",".","GO:0005829|cytosol;","GO:0046872|metal ion binding;",".","."]
["ENSRNOG00000028767",17,1.430299567,61,3.924156729,0.364485841,-1.456065322,{"v":4.74088e-05,"d":"4.74E-05"},{"v":4.51362e-05,"d":"4.51E-05"},"down","yes","AABR07001926.1","protein_coding","chr1:62509056-62528102:-","gi|148673829|gb|EDL05776.1|",1795,0,"mCG22919 [Mus musculus]","gi|331028450|ref|NG_028550.1|",676,0,"Mus musculus zinc finger protein 945 pseudogene (LOC100534296) on chromosome 17","Q8TAQ5",398,{"v":6e-127,"d":"6.00E-127"},"Zinc finger protein 420",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000017246",6,0.504811612,35,2.251565336,0.224204736,-2.157111341,{"v":5.28057e-05,"d":"5.28E-05"},{"v":5.00381e-05,"d":"5.00E-05"},"down","yes","Adad1","protein_coding","chr2:119948926-120005913:+","gi|564336241|ref|XP_006232340.1|",2998,0,"PREDICTED: adenosine deaminase domain-containing protein 1 isoform X1 [Rattus norvegicus]","gi|672042074|ref|XM_006232278.2|",2037,0,"PREDICTED: Rattus norvegicus adenosine deaminase domain containing 1 (testis specific) (Adad1), transcript variant X1, mRNA","Q3KR54",1119,0,"Adenosine deaminase domain-containing protein 1",".",".",".",".","pfam02137","A_deamin","Adenosine-deaminase (editase) domain. Adenosine deaminases acting on RNA (ADARs) can deaminate adenosine to form inosine. In long double-stranded RNA, this process is non-specific; it occurs site-specifically in RNA transcripts. The former is important in defence against viruses, whereas the latter may affect splicing or untranslated regions. They are primarily nuclear proteins, but a longer isoform of ADAR1 is found predominantly in the cytoplasm. ADARs are derived from the Tad1-like tRNA deaminases that are present across eukaryotes. These in turn belong to the nucleotide/nucleic acid deaminase superfamily and are characterized by a distinct insert between the two conserved cysteines that are involved in binding zinc.","GO:0006382|adenosine to inosine editing;GO:0006396|RNA processing;GO:0007286|spermatid development;","GO:0005634|nucleus;GO:0005730|nucleolus;GO:0005737|cytoplasm;","GO:0003723|RNA binding;GO:0003725|double-stranded RNA binding;GO:0003726|double-stranded RNA adenosine deaminase activity;GO:0004000|adenosine deaminase activity;GO:0008251|tRNA-specific adenosine deaminase activity;",".","."]
["ENSRNOG00000064496",21,1.766840642,69,4.438800235,0.39804464,-1.328997859,{"v":5.41538e-05,"d":"5.42E-05"},{"v":5.12531e-05,"d":"5.13E-05"},"down","yes","ENSRNOG00000064496","lncRNA","chr10:96054824-96060758:-",".",".",".",".","gi|672069706|ref|XM_006247567.2|",2849,0,"PREDICTED: Rattus norvegicus potassium inwardly-rectifying channel, subfamily J, member 2 (Kcnj2), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam03411","Peptidase_M74","Penicillin-insensitive murein endopeptidase.",".",".",".",".","."]
["ENSRNOG00000054458",28,2.355787522,83,5.339426369,0.441206107,-1.180475335,{"v":5.45309e-05,"d":"5.45E-05"},{"v":5.15473E-5,"d":"5.15E-05"},"down","yes","Kcnmb4","protein_coding","chr7:52066136-52119278:-","gi|13027406|ref|NP_076450.1|",1062,{"v":9e-142,"d":"9.00E-142"},"calcium-activated potassium channel subunit beta-4 [Rattus norvegicus]","gi|171846555|gb|BC161829.1|",1201,0,"Rattus norvegicus potassium large conductance calcium-activated channel, subfamily M, beta member 4, mRNA (cDNA clone MGC:187309 IMAGE:9033053), complete cds","Q9ESK8",413,{"v":3e-143,"d":"3.00E-143"},"Calcium-activated potassium channel subunit beta-4",".",".",".",".","pfam03185","CaKB","Calcium-activated potassium channel, beta subunit.","GO:0001508|action potential;GO:0005513|detection of calcium ion;GO:0006813|potassium ion transport;GO:0019228|neuronal action potential;GO:0071805|potassium ion transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0008076|voltage-gated potassium channel complex;","GO:0015269|calcium-activated potassium channel activity;GO:0015459|potassium channel regulator activity;","K04941","KCNMB4; potassium large conductance calcium-activated channel subfamily M beta member 4"]
["ENSRNOG00000030160",23,1.935111179,73,4.696121987,0.412065782,-1.279053428,{"v":5.5542e-05,"d":"5.55E-05"},{"v":5.24393e-05,"d":"5.24E-05"},"down","yes","Zfp819","protein_coding","chr1:94035679-94048760:+","gi|62078765|ref|NP_001014039.1|",3272,0,"zinc finger protein 175 [Rattus norvegicus]","gi|672036387|ref|XM_006229044.2|",2338,0,"PREDICTED: Rattus norvegicus zinc finger protein 819 (Zfp819), transcript variant X4, mRNA","Q9Y473",584,0,"Zinc finger protein 175",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;GO:0043065|positive regulation of apoptotic process;GO:0045892|negative regulation of transcription, DNA-templated;","GO:0005634|nucleus;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0046872|metal ion binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSRNOG00000003455",38,3.197140209,102,6.561704695,0.487242318,-1.037288654,{"v":5.58839e-05,"d":"5.59E-05"},{"v":5.27256e-05,"d":"5.27E-05"},"down","yes","Zfp13","protein_coding","chr10:12615190-12623615:-","gi|755556566|ref|XP_011244722.1|",2427,0,"PREDICTED: zinc finger protein 13 isoform X2 [Mus musculus]","gi|755556565|ref|XM_011246420.1|",1492,0,"PREDICTED: Mus musculus zinc finger protein 13 (Zfp13), transcript variant X1, mRNA","P10754",863,0,"Zinc finger protein 13",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;GO:0010729|positive regulation of hydrogen peroxide biosynthetic process;GO:1901030|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;","GO:0005739|mitochondrion;GO:0016021|integral component of membrane;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSRNOG00000066847",38,3.197140209,102,6.561704695,0.487242318,-1.037288654,{"v":5.58839e-05,"d":"5.59E-05"},{"v":5.27256e-05,"d":"5.27E-05"},"down","yes","Gnrh1","protein_coding","chr15:41942339-41976690:+","gi|157820083|ref|NP_001102341.1|",1971,0,"BTB/POZ domain-containing protein KCTD9 [Rattus norvegicus]","gi|672078361|ref|XM_006252142.2|",3393,0,"PREDICTED: Rattus norvegicus potassium channel tetramerization domain containing 9 (Kctd9), transcript variant X2, mRNA","Q7L273",753,0,"BTB/POZ domain-containing protein KCTD9","MA3328",114,{"v":5e-26,"d":"5.00E-26"},"COG1357","pfam02214","BTB_2","BTB/POZ domain. In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.",".",".",".",".","."]
["ENSRNOG00000012521",14,1.177893761,54,3.473843662,0.339075064,-1.560323405,{"v":5.6218e-05,"d":"5.62E-05"},{"v":5.30132e-05,"d":"5.30E-05"},"down","yes","Shisa2","protein_coding","chr15:33805958-33811013:+","gi|300794277|ref|NP_001178865.1|",1255,{"v":3e-167,"d":"3.00E-167"},"protein shisa-2 homolog precursor [Rattus norvegicus]","gi|256355184|ref|NM_145463.5|",1328,0,"Mus musculus shisa family member 2 (Shisa2), mRNA","Q8QZV2",484,{"v":4E-167,"d":"4.00E-167"},"Protein shisa-2 homolog",".",".",".",".","pfam13908","Shisa","Wnt and FGF inhibitory regulator. Shisa is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface.","GO:0030178|negative regulation of Wnt signaling pathway;GO:0040037|negative regulation of fibroblast growth factor receptor signaling pathway;","GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000029830",2,0.168270537,23,1.479600078,0.11372704,-3.136352781,{"v":5.78599e-05,"d":"5.79E-05"},{"v":5.44107e-05,"d":"5.44E-05"},"down","yes","Adm2","protein_coding","chr7:120393179-120396331:+","gi|148672410|gb|EDL04357.1|",867,{"v":2E-107,"d":"2.00E-107"},"adrenomedullin 2, isoform CRA_a, partial [Mus musculus]","gi|48474199|dbj|AB181297.1|",1032,0,"Rattus norvegicus adm2 mRNA for adrenomedullin 2, complete cds","P61312",273,{"v":3e-85,"d":"3.00E-85"},"ADM2",".",".",".",".","pfam03154","Atrophin-1","Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.","GO:0001525|angiogenesis;GO:0006468|protein phosphorylation;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007586|digestion;GO:0007631|feeding behavior;GO:0010628|positive regulation of gene expression;GO:0045766|positive regulation of angiogenesis;GO:0045776|negative regulation of blood pressure;","GO:0005576|extracellular region;","GO:0005179|hormone activity;GO:0044877|protein-containing complex binding;","K25343","ADM2; adrenomedullin-2"]
["ENSRNOG00000021400",15,1.26202903,56,3.602504538,0.3503199,-1.513255152,{"v":6.04865e-05,"d":"6.05E-05"},{"v":5.67534e-05,"d":"5.68E-05"},"down","yes","Magee2","protein_coding","chrX:69942533-69944657:+","gi|157818623|ref|NP_001100411.1|",2575,0,"melanoma-associated antigen E2 [Rattus norvegicus]","gi|672087937|ref|XM_008773342.1|",2125,0,"PREDICTED: Rattus norvegicus melanoma antigen, family E, 2 (Magee2), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam01454","MAGE","MAGE family. The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumors but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.","GO:0000122|negative regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;",".",".","."]
["ENSRNOG00000051102",35,2.944734403,96,6.175722066,0.476824308,-1.068470309,{"v":6.2004e-05,"d":"6.20E-05"},{"v":5.80771E-5,"d":"5.81E-05"},"down","yes","AABR07004269.3","pseudogene","chr1:127424015-127431922:+","gi|672013958|ref|XP_008772828.1|",2955,0,"PREDICTED: LOW QUALITY PROTEIN: DNA topoisomerase 1-like [Rattus norvegicus]","gi|672013957|ref|XM_008774606.1|",2269,0,"PREDICTED: Rattus norvegicus similar to topoisomerase (DNA) I (LOC499179), mRNA","Q9WUL0",1126,0,"DNA topoisomerase 1","YOL006c_1",409,{"v":1e-132,"d":"1.00E-132"},"COG3569","pfam02919","Topoisom_I_N","Eukaryotic DNA topoisomerase I, DNA binding fragment. Topoisomerase I promotes the relaxation of DNA superhelical tension by introducing a transient single-stranded break in duplex DNA and are vital for the processes of replication, transcription, and recombination. This family may be more than one structural domain.",".",".",".",".","."]
["ENSRNOG00000014960",34,2.860599134,94,6.047061189,0.473056092,-1.079916836,{"v":6.39793e-05,"d":"6.40E-05"},{"v":5.98244e-05,"d":"5.98E-05"},"down","yes","Bard1","protein_coding","chr9:72623155-72694265:-","gi|149015988|gb|EDL75269.1|",3422,0,"BRCA1 associated RING domain 1 [Rattus norvegicus]","gi|12018307|ref|NM_022622.1|",2230,0,"Rattus norvegicus BRCA1 associated RING domain 1 (Bard1), mRNA","Q9QZH2",1319,0,"BRCA1-associated RING domain protein 1",".",".",".",".","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0006281|DNA repair;GO:0007283|spermatogenesis;GO:0042325|regulation of phosphorylation;GO:0043065|positive regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0046826|negative regulation of protein export from nucleus;GO:0085020|protein K6-linked ubiquitination;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0016607|nuclear speck;GO:0031436|BRCA1-BARD1 complex;GO:0036464|cytoplasmic ribonucleoprotein granule;GO:0070531|BRCA1-A complex;","GO:0003674|molecular_function;GO:0003723|RNA binding;GO:0004842|ubiquitin-protein transferase activity;GO:0042803|protein homodimerization activity;GO:0046872|metal ion binding;GO:0046982|protein heterodimerization activity;","K10683","BARD1; BRCA1-associated RING domain protein 1"]
["ENSRNOG00000015859",12,1.009623224,49,3.152191471,0.32029248,-1.642538169,{"v":6.82882e-05,"d":"6.83E-05"},{"v":6.36566e-05,"d":"6.37E-05"},"down","yes","Chdh","protein_coding","chr16:5194269-5225537:+","gi|38454200|ref|NP_942026.1|",3182,0,"choline dehydrogenase, mitochondrial [Rattus norvegicus]","gi|55741626|ref|NM_198731.2|",3402,0,"Rattus norvegicus choline dehydrogenase (Chdh), mRNA","Q6UPE0",1230,0,"Choline dehydrogenase, mitochondrial","mll7609",547,0,"COG2303","pfam00732","GMC_oxred_N","GMC oxidoreductase. This family of proteins bind FAD as a cofactor.","GO:0019285|glycine betaine biosynthetic process from choline;","GO:0005743|mitochondrial inner membrane;","GO:0008812|choline dehydrogenase activity;GO:0016491|oxidoreductase activity;GO:0050660|flavin adenine dinucleotide binding;","K00108","betA, CHDH; choline dehydrogenase [EC:1.1.99.1]"]
["ENSRNOG00000001338",7,0.588946881,37,2.380226213,0.247433155,-2.014889269,{"v":6.90397e-05,"d":"6.90E-05"},{"v":6.43022e-05,"d":"6.43E-05"},"down","yes","Hpd","protein_coding","chr12:33381231-33392766:+","gi|8393557|ref|NP_058929.1|",2118,0,"4-hydroxyphenylpyruvate dioxygenase [Rattus norvegicus]","gi|51980499|gb|BC081819.1|",1336,0,"Rattus norvegicus 4-hydroxyphenylpyruvate dioxygenase, mRNA (cDNA clone MGC:93530 IMAGE:7107086), complete cds","P32755",820,0,"4-hydroxyphenylpyruvate dioxygenase","all0771",198,{"v":6E-57,"d":"6.00E-57"},"COG3185","pfam00903","Glyoxalase","Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily.","GO:0006559|L-phenylalanine catabolic process;GO:0006572|tyrosine catabolic process;","GO:0000139|Golgi membrane;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005794|Golgi apparatus;","GO:0003868|4-hydroxyphenylpyruvate dioxygenase activity;GO:0046872|metal ion binding;","K00457","HPD, hppD; 4-hydroxyphenylpyruvate dioxygenase [EC:1.13.11.27]"]
["ENSRNOG00000020165",7,0.588946881,37,2.380226213,0.247433155,-2.014889269,{"v":6.90397e-05,"d":"6.90E-05"},{"v":6.43022e-05,"d":"6.43E-05"},"down","yes","Ahsp","protein_coding","chr1:182880076-182885506:+","gi|157820931|ref|NP_001099769.1|",469,{"v":9e-56,"d":"9.00E-56"},"alpha-hemoglobin-stabilizing protein [Rattus norvegicus]","gi|157820930|ref|NM_001106299.1|",499,0,"Rattus norvegicus alpha hemoglobin stabilizing protein (Ahsp), mRNA","Q9CY02",153,{"v":7E-45,"d":"7.00E-45"},"Alpha-hemoglobin-stabilizing protein",".",".",".",".","pfam09236","AHSP","Alpha-haemoglobin stabilizing protein. Alpha-haemoglobin stabilizing protein (AHSP) acts a molecular chaperone for free alpha-haemoglobin, preventing the harmful aggregation of alpha-haemoglobin during normal erythroid cell development: it specifically protects free alpha-haemoglobin from precipitation. AHSP adopts a helical secondary structure consisting of an elongated antiparallel three alpha-helix bundle.","GO:0006457|protein folding;GO:0008150|biological_process;GO:0030218|erythrocyte differentiation;GO:0050821|protein stabilization;","GO:0005575|cellular_component;GO:0005737|cytoplasm;","GO:0003674|molecular_function;GO:0030492|hemoglobin binding;",".","."]
["ENSRNOG00000062559",1,0.084135269,19,1.222278326,0.068834787,-3.860718339,{"v":7.23539e-05,"d":"7.24E-05"},{"v":6.71821e-05,"d":"6.72E-05"},"down","yes","ENSRNOG00000062559","lncRNA","chr18:27470677-27474178:+",".",".",".",".","gi|625276646|ref|XM_007631761.1|",71,{"v":4e-27,"d":"4.00E-27"},"PREDICTED: Cricetulus griseus collagen alpha-1(III) chain-like (LOC103162556), mRNA",".",".",".",".",".",".",".",".","pfam15268","Dapper","Dapper. This is a family of signalling proteins. They act in a diverse range of signaling pathways and have a range of binding partners. They act as homo- and heterodimers.",".",".",".",".","."]
["ENSRNOG00000026344",20,1.682705373,66,4.24580892,0.396321503,-1.33525685,{"v":7.41704e-05,"d":"7.42E-05"},{"v":6.87633e-05,"d":"6.88E-05"},"down","yes","Togaram2","protein_coding","chr6:23771052-23828499:-","gi|672020443|ref|XP_002726744.3|",5366,0,"PREDICTED: protein FAM179A [Rattus norvegicus]","gi|672020442|ref|XM_002726698.4|",3232,0,"PREDICTED: Rattus norvegicus family with sequence similarity 179, member A (Fam179a), mRNA",".",".",".",".",".",".",".",".","pfam12348","CLASP_N","CLASP N terminal. This region is found at the N terminal of CLIP-associated proteins (CLASPs).  CLASPs are widely conserved microtubule plus-end-tracking proteins that regulate the stability of dynamic microtubules. In yeast, Drosophila, and Xenopus, a single CLASP orthologue is present. In mammals, a second paralogue (CLASP2) exists which has some functional overlap with CLASP1.","GO:0000226|microtubule cytoskeleton organization;GO:0090307|mitotic spindle assembly;","GO:0005815|microtubule organizing center;GO:0005876|spindle microtubule;GO:0005881|cytoplasmic microtubule;GO:0005929|cilium;GO:0072686|mitotic spindle;","GO:0008017|microtubule binding;","K24886","TOGARAM; TOG array regulator of axonemal microtubules protein"]
["ENSRNOG00000025404",13,1.093758492,51,3.280852347,0.333376323,-1.584776449,{"v":7.52034e-05,"d":"7.52E-05"},{"v":6.96261e-05,"d":"6.96E-05"},"down","yes","Dppa4","protein_coding","chr11:52570286-52578797:-","gi|293352174|ref|XP_001063552.2|",1224,{"v":3e-163,"d":"3.00E-163"},"PREDICTED: developmental pluripotency-associated protein 4 isoform X1 [Rattus norvegicus]","gi|672026020|ref|XM_003752488.3|",1220,0,"PREDICTED: Rattus norvegicus similar to developmental pluripotency associated 4 isoform 1 (LOC685378), transcript variant X1, mRNA","D3Z8Y2",471,{"v":8e-163,"d":"8.00E-163"},"Developmental pluripotency-associated protein 4",".",".",".",".","pfam14047","DCR","Dppa2/4 conserved region. This domain has been characterized in the finding of a developmental pluripotency associated gene (Dppa) in the lower vertebrate Xenopus laevis. Previous to this discovery, Dppa genes were known only in higher vertebrates. The domain is subject to structure determination by the Joint Center of Structural Genomics.","GO:0048731|system development;GO:0060484|lung-associated mesenchyme development;","GO:0005634|nucleus;","GO:0003682|chromatin binding;",".","."]
["ENSRNOG00000009022",25,2.103381716,76,4.889113302,0.430217421,-1.216862149,{"v":7.64068e-05,"d":"7.64E-05"},{"v":7.06441e-05,"d":"7.06E-05"},"down","yes","Rtkn","protein_coding","chr4:115640774-115657952:+","gi|148666652|gb|EDK99068.1|",2840,0,"rhotekin, isoform CRA_b, partial [Mus musculus]","gi|34576548|ref|NM_184046.1|",2567,0,"Rattus norvegicus rhotekin (Rtkn), mRNA","Q6V7V2",1065,0,"Rhotekin",".",".",".",".","pfam08174","Anillin","Cell division protein anillin. Anillin is a protein involved in septin organisation during cell division.  It is an actin binding protein that is localized to the cleavage furrow, and it maintains the localisation of active myosin, which ensures the spatial control of concerted contraction during cytokinesis.","GO:0000281|mitotic cytokinesis;GO:0000915|actomyosin contractile ring assembly;GO:0006915|apoptotic process;GO:0007165|signal transduction;GO:0007266|Rho protein signal transduction;GO:0031106|septin ring organization;GO:0032185|septin cytoskeleton organization;GO:0042981|regulation of apoptotic process;GO:0043086|negative regulation of catalytic activity;","GO:0005826|actomyosin contractile ring;","GO:0005095|GTPase inhibitor activity;GO:0005525|GTP binding;GO:0031267|small GTPase binding;","K24024","RTKN; rhotekin"]
["ENSRNOG00000063519",24,2.019246448,74,4.760452426,0.424171122,-1.23728169,{"v":7.66998e-05,"d":"7.67E-05"},{"v":7.0903e-05,"d":"7.09E-05"},"down","yes","ENSRNOG00000063519","lncRNA","chr13:45843939-45846361:-","gi|148701441|gb|EDL33388.1|",198,{"v":1e-16,"d":"1.00E-16"},"mCG1045525, partial [Mus musculus]","gi|672074167|ref|XR_595471.1|",219,{"v":3e-109,"d":"3.00E-109"},"PREDICTED: Rattus norvegicus uncharacterized LOC102552665 (LOC102552665), ncRNA",".",".",".",".",".",".",".",".","pfam09961","DUF2195","Uncharacterized protein conserved in bacteria (DUF2195). This domain, found in various hypothetical bacterial proteins, has no known function.",".",".",".",".","."]
["ENSRNOG00000018792",0,0.042067634,17,1.093617449,0.038466499,-4.700253667,{"v":7.77397e-05,"d":"7.77E-05"},{"v":7.17912e-05,"d":"7.18E-05"},"down","yes","Tekt4","protein_coding","chr10:14487760-14492936:+","gi|62078659|ref|NP_001013987.1|",2347,0,"tektin-4 [Rattus norvegicus]","gi|62078658|ref|NM_001013965.1|",1515,0,"Rattus norvegicus tektin 4 (Tekt4), mRNA","Q6AXV2",908,0,"Tektin-4",".",".",".",".","pfam03148","Tektin","Tektin family. Tektins are cytoskeletal proteins. They have been demonstrated in such cellular sites as centrioles, basal bodies, and along ciliary and flagellar doublet microtubules. Tektins form unique protofilaments, organized as longitudinal polymers of tektin heterodimers with axial periodicity matching tubulin. Tektin polypeptides consist of several alpha-helical regions that are predicted to form coiled coils. Indeed, tektins share considerable structural similarities with intermediate filament proteins. Possible functional roles for tektins are: stabilisation of tubulin protofilaments; attachment of A and B-tubules in ciliary/flagellar microtubule doublets and C-tubules in centrioles; binding of axonemal components.","GO:0060271|cilium assembly;GO:0060294|cilium movement involved in cell motility;GO:0060378|regulation of brood size;","GO:0015630|microtubule cytoskeleton;GO:0036126|sperm flagellum;GO:0097225|sperm midpiece;GO:0097228|sperm principal piece;",".","K18631","TEKT4; tektin-4"]
["ENSRNOG00000031397",0,0.042067634,17,1.093617449,0.038466499,-4.700253667,{"v":7.77397e-05,"d":"7.77E-05"},{"v":7.17912e-05,"d":"7.18E-05"},"down","yes","Stk32b","protein_coding","chr14:73078061-73336458:+","gi|157821711|ref|NP_001100694.1|",2162,0,"serine/threonine-protein kinase 32B [Rattus norvegicus]","gi|255003773|ref|NM_022416.2|",1448,0,"Mus musculus serine/threonine kinase 32B (Stk32b), mRNA","Q9JJX8",821,0,"Serine/threonine-protein kinase 32B",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0018105|peptidyl-serine phosphorylation;GO:0035556|intracellular signal transduction;",".","GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;","K08793","STK32, YANK; serine/threonine kinase 32 [EC:2.7.11.1]"]
["ENSRNOG00000039183",36,3.028869671,97,6.240052504,0.485391697,-1.042778666,{"v":7.92736e-05,"d":"7.93E-05"},{"v":7.3059e-05,"d":"7.31E-05"},"down","yes","Cip2a","protein_coding","chr11:51795024-51822938:-","gi|109493232|ref|XP_340983.3|",4435,0,"PREDICTED: protein CIP2A [Rattus norvegicus]","gi|672071002|ref|XM_340982.7|",3432,0,"PREDICTED: Rattus norvegicus similar to RIKEN cDNA C330027C09 (RGD1310335), mRNA","Q8BWY9",1615,0,"Protein CIP2A",".",".",".",".","pfam02463","SMC_N","RecF/RecN/SMC N terminal domain. This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics.   This family also includes the RecF and RecN proteins that are involved in DNA metabolizm and recombination.","GO:0007283|spermatogenesis;GO:2000179|positive regulation of neural precursor cell proliferation;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0042803|protein homodimerization activity;",".","."]
["ENSRNOG00000021553",14,1.177893761,53,3.409513224,0.345472706,-1.533356358,{"v":8.14564e-05,"d":"8.15E-05"},{"v":7.50072e-05,"d":"7.50E-05"},"down","yes","Nckap5","protein_coding","chr13:37370792-38283268:-","gi|672027054|ref|XP_008759654.1|",8222,0,"PREDICTED: nck-associated protein 5 isoform X2 [Rattus norvegicus]","gi|672073910|ref|XM_008769508.1|",5713,0,"PREDICTED: Rattus norvegicus NCK-associated protein 5 (Nckap5), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam15246","NCKAP5","Nck-associated protein 5, Peripheral clock protein. NCKAP5 is short for Nck-associated protein 5, which is also known as the Peripheral clock protein. NCKAP5 is a protein family, which interacts with the SH3-containing region of the adaptor protein Nck. Nck is a protein that interacts with receptor tyrosine kinases and guanine nucleotide exchange factor Sos. The role of Nck can be thought of as similar to Grb2. The role of NCKAP5 is to assist Nck with its adaptor protein role.","GO:0001578|microtubule bundle formation;GO:0007019|microtubule depolymerization;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0035371|microtubule plus-end;","GO:0003674|molecular_function;",".","."]
["ENSRNOG00000029798",14,1.177893761,53,3.409513224,0.345472706,-1.533356358,{"v":8.14564e-05,"d":"8.15E-05"},{"v":7.50072e-05,"d":"7.50E-05"},"down","yes","Lrrc4c","protein_coding","chr3:83483851-83687774:+","gi|157820475|ref|NP_001101223.1|",3330,0,"leucine-rich repeat-containing protein 4C precursor [Rattus norvegicus]","gi|45752212|emb|BX813336.4|",3072,0,"Mouse DNA sequence from clone RP23-207B5 on chromosome 2, complete sequence","Q8C031",1284,0,"Leucine-rich repeat-containing protein 4C","SPy1798",75.5,{"v":3e-12,"d":"3.00E-12"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0008150|biological_process;GO:0050770|regulation of axonogenesis;GO:0050804|modulation of chemical synaptic transmission;GO:0099560|synaptic membrane adhesion;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098978|glutamatergic synapse;GO:0099061|integral component of postsynaptic density membrane;","GO:0003674|molecular_function;GO:0050839|cell adhesion molecule binding;GO:0098632|cell-cell adhesion mediator activity;","K07523","LRRC4C, NGL1; netrin-G1 ligand"]
["ENSRNOG00000017109",34,2.860599134,93,5.982730751,0.478142717,-1.064486795,{"v":8.49491e-05,"d":"8.49E-05"},{"v":7.80254E-5,"d":"7.80E-05"},"down","yes","Rassf7","protein_coding","chr1:196320902-196323770:+","gi|157821403|ref|NP_001099787.1|",1085,{"v":2E-140,"d":"2.00E-140"},"ras association domain-containing protein 7 [Rattus norvegicus]","gi|672038849|ref|XM_006230539.2|",1279,0,"PREDICTED: Rattus norvegicus Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 (Rassf7), transcript variant X3, mRNA","Q9DD19",363,{"v":1e-118,"d":"1.00E-118"},"Ras association domain-containing protein 7",".",".",".",".","pfam00788","RA","Ras association (RalGDS/AF-6) domain. RasGTP effectors (in cases of AF6, canoe and RalGDS); putative RasGTP effectors in other cases. Recent evidence (not yet in MEDLINE) shows that some RA domains do NOT bind RasGTP. Predicted structure similar to that determined, and that of the RasGTP-binding domain of Raf kinase.","GO:0007165|signal transduction;GO:0070507|regulation of microtubule cytoskeleton organization;","GO:0034451|centriolar satellite;",".","K09855","RASSF7_8; Ras association domain-containing protein 7/8"]
["ENSRNOG00000064799",34,2.860599134,93,5.982730751,0.478142717,-1.064486795,{"v":8.49491e-05,"d":"8.49E-05"},{"v":7.80254E-5,"d":"7.80E-05"},"down","yes","Tmed8","protein_coding","chr6:106810420-106843216:-","gi|109479724|ref|XP_001061720.1|",1252,{"v":1E-153,"d":"1.00E-153"},"PREDICTED: protein TMED8 isoform X1 [Rattus norvegicus]","gi|672020986|ref|XM_001061720.4|",3371,0,"PREDICTED: Rattus norvegicus similar to transmembrane emp24 domain containing 8 (LOC681943), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam13897","GOLD_2","Golgi-dynamics membrane-trafficking. Sec14-like Golgi-trafficking domain The GOLD domain is always found combined with lipid- or membrane-association domains.",".",".",".",".","."]
["ENSRNOG00000070099",8,0.673082149,39,2.508887089,0.268279171,-1.898193044,{"v":8.57592e-05,"d":"8.58E-05"},{"v":7.87297e-05,"d":"7.87E-05"},"down","yes","Crb3","protein_coding","chr9:1896623-1903859:+","gi|564366823|ref|XP_006244365.1|",519,{"v":2e-62,"d":"2.00E-62"},"PREDICTED: protein crumbs homolog 3 isoform X1 [Rattus norvegicus]","gi|298889082|emb|FQ223867.1|",955,0,"Rattus norvegicus TL0ACA84YK03 mRNA sequence","Q8QZT4",128,{"v":1e-34,"d":"1.00E-34"},"Protein crumbs homolog 3",".",".",".",".","pfam14610","DUF4448","Protein of unknown function (DUF4448). This is a family of predicted membrane glycoproteins from fungi. However there appears, visually, to be some similarity with the family of GPI-anchored fungal proteins, pfam10342.",".",".",".",".","."]
["ENSRNOG00000056973",11,0.925487955,46,2.959200157,0.31274936,-1.676921163,{"v":9.01385e-05,"d":"9.01E-05"},{"v":8.24304e-05,"d":"8.24E-05"},"down","yes","Snora17","snoRNA","chr3:9466700-9466831:-",".",".",".",".","gi|908662265|tpe|LN871987.1|",108,{"v":3e-48,"d":"3.00E-48"},"TPA: Mus musculus SNORA17 (ACA17) gene for small nucleolar RNA SNORA17 (ACA17)",".",".",".",".",".",".",".",".","pfam15257","DUF4590","Domain of unknown function (DUF4590). This family of proteins remains to be characterized and is a domain of unknown function. This domain family is found in eukaryotes, and is approximately 120 amino acids in length. There are two conserved sequence motifs: CCE and PCY. In humans, the gene encoding this protein lies in the position, chromosome 1 open reading frame 173.",".",".",".",".","."]
["ENSRNOG00000061038",17,1.430299567,59,3.795495853,0.376841294,-1.407971033,{"v":9.57841e-05,"d":"9.58E-05"},{"v":8.72707e-05,"d":"8.73E-05"},"down","yes","ENSRNOG00000061038","protein_coding","chr11:51622413-51762971:-","gi|672026175|ref|XP_008756037.1|",8894,0,"PREDICTED: myosin-15 isoform X1 [Rattus norvegicus]","gi|672026174|ref|XM_008757815.1|",5730,0,"PREDICTED: Rattus norvegicus myosin, heavy chain 15 (Myh15), transcript variant X1, mRNA","Q9Y2K3",2530,0,"Myosin-15","SPCC645.05c",663,0,"COG5022","pfam00063","Myosin_head","Myosin head (motor domain).","GO:0002074|extraocular skeletal muscle development;","GO:0005575|cellular_component;GO:0005829|cytosol;GO:0016459|myosin complex;GO:0043231|intracellular membrane-bounded organelle;","GO:0003674|molecular_function;GO:0003774|motor activity;GO:0005524|ATP binding;GO:0051015|actin filament binding;","K24220","MYH1s; myosin heavy chain 1/2/3/4/8/13/7B/15"]
["ENSRNOG00000053317",5,0.420676343,31,1.994243584,0.210945316,-2.245059041,{"v":9.61707e-05,"d":"9.62E-05"},{"v":8.75936e-05,"d":"8.76E-05"},"down","yes","Efcab11","protein_coding","chr6:119008919-119162046:-","gi|66730501|ref|NP_001019521.1|",857,{"v":3e-110,"d":"3.00E-110"},"EF-hand calcium-binding domain-containing protein 11 [Rattus norvegicus]","gi|66730500|ref|NM_001024350.1|",1463,0,"Rattus norvegicus EF-hand calcium binding domain 11 (Efcab11), mRNA","Q6AXQ2",334,{"v":9e-112,"d":"9.00E-112"},"EF-hand calcium-binding domain-containing protein 11","SPAC3A12.14",61.6,{"v":3E-10,"d":"3.00E-10"},"COG5126","pfam13499","EF-hand_7","EF-hand domain pair.",".",".","GO:0005509|calcium ion binding;","K23853","EFCAB11; EF-hand calcium-binding domain-containing protein 11"]
["ENSRNOG00000001115",2,0.168270537,22,1.41526964,0.118896451,-3.072222444,{"v":9.79506e-05,"d":"9.80E-05"},{"v":8.91402e-05,"d":"8.91E-05"},"down","yes","Slc29a4","protein_coding","chr12:11853540-11874834:-","gi|157787066|ref|NP_001099381.1|",2572,0,"equilibrative nucleoside transporter 4 [Rattus norvegicus]","gi|157787065|ref|NM_001105911.1|",2745,0,"Rattus norvegicus solute carrier family 29 member 4 (Slc29a4), mRNA","Q8R139",970,0,"Equilibrative nucleoside transporter 4",".",".",".",".","pfam01733","Nucleoside_tran","Nucleoside transporter. This is a family of nucleoside transporters. In mammalian cells nucleoside transporters transport nucleoside across the plasma membrane and are essential for nucleotide synthesis via the salvage pathways for cells that lack their own de novo synthesis pathways. Also in this family is mouse and human nucleolar protein HNP36, a protein of unknown function; although it has been hypothesised to be a plasma membrane nucleoside transporter.","GO:0006836|neurotransmitter transport;GO:0015695|organic cation transport;GO:0015844|monoamine transport;GO:0042908|xenobiotic transport;GO:0051610|serotonin uptake;GO:0051615|histamine uptake;GO:0051620|norepinephrine uptake;GO:0051625|epinephrine uptake;GO:0090494|dopamine uptake;GO:0098655|cation transmembrane transport;GO:0140115|export across plasma membrane;GO:1901642|nucleoside transmembrane transport;GO:1901998|toxin transport;GO:1903825|organic acid transmembrane transport;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0098793|presynapse;","GO:0005326|neurotransmitter transporter activity;GO:0005337|nucleoside transmembrane transporter activity;GO:0005342|organic acid transmembrane transporter activity;GO:0008324|cation transmembrane transporter activity;GO:0008504|monoamine transmembrane transporter activity;GO:0015101|organic cation transmembrane transporter activity;GO:0015562|efflux transmembrane transporter activity;GO:0019534|toxin transmembrane transporter activity;GO:0042910|xenobiotic transmembrane transporter activity;","K03323","SLC29A4, ENT4; solute carrier family 29 (equilibrative nucleoside transporter), member 4"]
["ENSRNOG00000067018",18,1.514434836,61,3.924156729,0.385926185,-1.373603161,{"v":9.90565e-05,"d":"9.91E-05"},{"v":9.00864e-05,"d":"9.01E-05"},"down","yes","ENSRNOG00000067018","protein_coding","chr20:3864200-3870816:-","gi|148702471|gb|EDL34418.1|",242,{"v":1E-22,"d":"1.00E-22"},"mCG1042149, partial [Mus musculus]","gi|46237588|emb|BX883045.1|",540,0,"Rattus norvegicus chromosome 20, major histocompatibility complex, assembled from 40 BACs, strain Brown Norway (BN/ssNHsd), RT1n haplotype; segment 4/11","P46935",53.1,1e-06,"E3 ubiquitin-protein ligase NEDD4",".",".",".",".","pfam10163","EnY2","Transcription factor e(y)2. EnY2 is a small transcription factor which is combined in a complex with the TAFII40 protein. The protein is conserved from paramecium to humans.",".",".",".",".","."]
["ENSRNOG00000003643",12,1.009623224,48,3.087861033,0.32696524,-1.612790825,1.00265E-4,{"v":9.10336e-05,"d":"9.10E-05"},"down","yes","ENSRNOG00000003643","protein_coding","chrX:49972330-50042056:+","gi|564322746|ref|XP_006227407.1|",3072,0,"PREDICTED: TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [Rattus norvegicus]","gi|672032323|ref|XM_008758432.1|",3554,0,"PREDICTED: Rattus norvegicus TGF-beta activated kinase 1/MAP3K7 binding protein 3 (Tab3), transcript variant X2, mRNA","Q571K4",1070,0,"TGF-beta-activated kinase 1 and MAP3K7-binding protein 3",".",".",".",".","pfam09770","PAT1","Topoisomerase II-associated protein PAT1. Members of this family are necessary for accurate chromosome transmission during cell division.","GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;",".","GO:0008270|zinc ion binding;GO:0043130|ubiquitin binding;GO:0070530|K63-linked polyubiquitin modification-dependent protein binding;","K12793","MAP3K7IP3, TAB3; TAK1-binding protein 3"]
["ENSRNOG00000069767",25,2.103381716,75,4.824782864,0.435953653,-1.197753326,0.000104278,{"v":9.45665e-05,"d":"9.46E-05"},"down","yes","Vom2r6","protein_coding","chr1:1161832-1224262:+","gi|153791928|ref|NP_001092929.1|",4360,0,"vomeronasal 2 receptor 6 precursor [Rattus norvegicus]","gi|153791927|ref|NM_001099459.1|",2526,0,"Rattus norvegicus vomeronasal 2 receptor, 6 (Vom2r6), mRNA","E9Q6I0",809,0,"Vomeronasal type-2 receptor 116",".",".",".",".","pfam02994","Transposase_22","L1 transposable element.",".",".",".",".","."]
["ENSRNOG00000030180",3,0.252405806,25,1.608260955,0.156943315,-2.671684514,1.0844E-4,{"v":9.81611e-05,"d":"9.82E-05"},"down","yes","Lrrc10b","protein_coding","chr1:207022919-207098045:-","gi|157820989|ref|NP_001101047.1|",1115,{"v":2e-147,"d":"2.00E-147"},"leucine-rich repeat-containing protein 10B [Rattus norvegicus]","gi|27356749|gb|AC125093.4|",1193,0,"Mus musculus BAC clone RP24-176F8 from chromosome 19, complete sequence",".",".",".",".","alr0124_1",83.6,{"v":2E-16,"d":"2.00E-16"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.",".",".",".",".","."]
["ENSRNOG00000067276",3,0.252405806,25,1.608260955,0.156943315,-2.671684514,1.0844E-4,{"v":9.81611e-05,"d":"9.82E-05"},"down","yes","ENSRNOG00000067276","protein_coding","chr9:113440096-113461706:+","gi|148705231|gb|EDL37178.1|",2152,0,"mCG23594 [Mus musculus]","gi|672018984|ref|XR_600914.1|",1748,0,"PREDICTED: Rattus norvegicus zinc finger protein 120-like (LOC102557117), misc_RNA","A6NN14",759,0,"Zinc finger protein 729","SPAC144.09c",106,{"v":2e-23,"d":"2.00E-23"},"COG5048","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000010447",13,1.093758492,50,3.216521909,0.34004385,-1.556207297,1.09453E-4,{"v":9.89794e-05,"d":"9.90E-05"},"down","yes","Tmod2","protein_coding","chr8:76325667-76365720:-","gi|344243749|gb|EGV99852.1|",1673,0,"Tropomodulin-2 [Cricetulus griseus]","gi|672062217|ref|XM_006243407.2|",1136,0,"PREDICTED: Rattus norvegicus tropomodulin 2 (Tmod2), transcript variant X1, mRNA","P70566",641,0,"Tropomodulin-2",".",".",".",".","pfam03250","Tropomodulin","Tropomodulin. Tropomodulin is a novel tropomyosin regulatory protein that binds to the end of erythrocyte tropomyosin and blocks head-to-tail association of tropomyosin along actin filaments. Limited proteolysis shows this protein is composed of two domains. The amino terminal domain contains the tropomyosin binding function.","GO:0006936|muscle contraction;GO:0007015|actin filament organization;GO:0007270|neuron-neuron synaptic transmission;GO:0007611|learning or memory;GO:0030239|myofibril assembly;GO:0045745|positive regulation of G protein-coupled receptor signaling pathway;GO:0051694|pointed-end actin filament capping;","GO:0005856|cytoskeleton;GO:0005865|striated muscle thin filament;GO:0030016|myofibril;GO:0030426|growth cone;GO:0043005|neuron projection;GO:0045202|synapse;","GO:0003779|actin binding;GO:0005523|tropomyosin binding;","K10370","TMOD; tropomodulin"]
["ENSRNOG00000055281",34,2.860599134,92,5.918400313,0.48333992,-1.04888994,1.12483E-4,1.01517E-4,"down","yes","Dcbld2","protein_coding","chr11:42125787-42179697:-","gi|18426846|ref|NP_569103.1|",3800,0,"discoidin, CUB and LCCL domain-containing protein 2 precursor [Rattus norvegicus]","gi|18426845|ref|NM_130419.1|",2298,0,"Rattus norvegicus discoidin, CUB and LCCL domain containing 2 (Dcbld2), mRNA","Q91ZV2",1466,0,"Discoidin, CUB and LCCL domain-containing protein 2",".",".",".",".","pfam00754","F5_F8_type_C","F5/8 type C domain. This domain is also known as the discoidin (DS) domain family.","GO:0030308|negative regulation of cell growth;GO:0042060|wound healing;","GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;",".","K24794","DCBLD; discoidin, CUB and LCCL domain-containing protein"]
["ENSRNOG00000046492",33,2.776463865,90,5.789739437,0.479549019,-1.060249802,0.00011643,1.04732E-4,"down","yes","Nemp1","protein_coding","chr7:63479951-63534602:+","gi|113205500|ref|NP_001037715.1|",4407,0,"signal transducer and activator of transcription 6 [Rattus norvegicus]","gi|113205499|ref|NM_001044250.1|",2629,0,"Rattus norvegicus signal transducer and activator of transcription 6, interleukin-4 induced (Stat6), mRNA","P52633",1613,0,"Signal transducer and transcription activator 6",".",".",".",".","pfam02864","STAT_bind","STAT protein, DNA binding domain. STAT proteins (Signal Transducers and Activators of Transcription) are a family of transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors. This family represents the DNA binding domain of STAT, which has an ig-like fold. STAT proteins also include an SH2 domain pfam00017.","GO:0071763|nuclear membrane organization;","GO:0005635|nuclear envelope;GO:0005637|nuclear inner membrane;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000019350",8,0.673082149,38,2.444556651,0.275339149,-1.860718339,0.000130642,1.16668E-4,"down","yes","Lyzl4","protein_coding","chr8:121248168-121255353:-","gi|672063637|ref|XP_006244185.2|",876,{"v":6e-106,"d":"6.00E-106"},"PREDICTED: lysozyme-like protein 4 isoform X2 [Rattus norvegicus]","gi|672063638|ref|XM_006244125.2|",694,0,"PREDICTED: Rattus norvegicus lysozyme-like 4 (Lyzl4), transcript variant X2, mRNA","D4ABW7",275,{"v":2E-85,"d":"2.00E-85"},"Lysozyme-like protein 4",".",".",".",".","pfam00062","Lys","C-type lysozyme/alpha-lactalbumin family. Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.","GO:0007342|fusion of sperm to egg plasma membrane involved in single fertilization;GO:0009566|fertilization;","GO:0001669|acrosomal vesicle;GO:0005615|extracellular space;GO:0036126|sperm flagellum;",".","K25438","LYZL4; lysozyme-like protein 4"]
["ENSRNOG00000055908",8,0.673082149,38,2.444556651,0.275339149,-1.860718339,0.000130642,1.16668E-4,"down","yes","AABR07065593.1","snoRNA","chr6:130591965-130592090:+",".",".",".",".","gi|908662930|tpe|LN872379.1|",102,{"v":6e-45,"d":"6.00E-45"},"TPA: Mus musculus SNORA28 (ACA28) gene for small nucleolar RNA SNORA28 (ACA28)",".",".",".",".",".",".",".",".","pfam00101","RuBisCO_small","Ribulose bisphosphate carboxylase, small chain.",".",".",".",".","."]
["ENSRNOG00000033202",0,0.042067634,16,1.029287011,0.040870655,-4.612790825,0.000133772,1.19209E-4,"down","yes","Fbxo41","protein_coding","chr4:118010978-118039406:-","gi|296482725|tpg|DAA24840.1|",3424,0,"TPA: F-box protein 41-like [Bos taurus]","gi|157823332|ref|NM_001107871.1|",3107,0,"Rattus norvegicus F-box protein 41 (Fbxo41), mRNA","Q6NS60",1315,0,"F-box only protein 41",".",".",".",".","pfam12937","F-box-like","F-box-like. This is an F-box-like family.",".",".",".","K10316","FBXO41; F-box protein 41"]
["ENSRNOG00000064986",17,1.430299567,58,3.731165415,0.383338557,-1.383308979,1.35437E-4,0.000120614,"down","yes","ENSRNOG00000064986","protein_coding","chr17:5100518-5102486:-","gi|850309643|ref|XP_012862499.1|",1050,{"v":3e-140,"d":"3.00E-140"},"PREDICTED: kinesin-like protein KIF2A [Echinops telfairi]","gi|589966399|ref|XM_006995667.1|",622,0,"PREDICTED: Peromyscus maniculatus bairdii kinesin heavy chain member 2A (Kif2a), transcript variant X4, mRNA","Q2NL05",409,{"v":1e-137,"d":"1.00E-137"},"Kinesin-like protein KIF2A","ECU11g0470",60.5,1e-09,"COG5059","pfam00225","Kinesin","Kinesin motor domain.",".",".",".",".","."]
["ENSRNOG00000006515",18,1.514434836,60,3.859826291,0.392358288,-1.349756419,0.000139229,1.23829E-4,"down","yes","Klhl15","protein_coding","chrX:58995461-59046069:+","gi|829865264|ref|XP_012640049.1|",3095,0,"PREDICTED: kelch-like protein 15 isoform X1 [Microcebus murinus]","gi|672087642|ref|XM_006257023.2|",1969,0,"PREDICTED: Rattus norvegicus kelch-like family member 15 (Klhl15), transcript variant X4, mRNA","D3ZA50",1171,0,"Kelch-like protein 15",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.","GO:0006511|ubiquitin-dependent protein catabolic process;GO:0016567|protein ubiquitination;GO:0071630|nuclear protein quality control by the ubiquitin-proteasome system;GO:2000042|negative regulation of double-strand break repair via homologous recombination;","GO:0005634|nucleus;",".","K10452","KLHL15; kelch-like protein 15"]
["ENSRNOG00000016883",35,2.944734403,93,5.982730751,0.492205738,-1.022666619,1.42922E-4,1.2698899999999999E-4,"down","yes","Entpd7","protein_coding","chr1:242559365-242601447:+","gi|82617566|ref|NP_444333.3|",2943,0,"ectonucleoside triphosphate diphosphohydrolase 7 [Mus musculus]","gi|261862334|ref|NM_053103.5|",1897,0,"Mus musculus ectonucleoside triphosphate diphosphohydrolase 7 (Entpd7), mRNA","Q3TCT4",1138,0,"Ectonucleoside triphosphate diphosphohydrolase 7","YER005w",248,{"v":8E-70,"d":"8.00E-70"},"COG5371","pfam01150","GDA1_CD39","GDA1/CD39 (nucleoside phosphatase) family.","GO:0006254|CTP catabolic process;GO:0006256|UDP catabolic process;GO:0009134|nucleoside diphosphate catabolic process;GO:0034656|nucleobase-containing small molecule catabolic process;GO:0046039|GTP metabolic process;GO:0046052|UTP catabolic process;GO:0050776|regulation of immune response;GO:0072539|T-helper 17 cell differentiation;","GO:0005794|Golgi apparatus;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030659|cytoplasmic vesicle membrane;","GO:0003924|GTPase activity;GO:0004382|guanosine-diphosphatase activity;GO:0017110|nucleoside-diphosphatase activity;GO:0017111|nucleoside-triphosphatase activity;GO:0043273|CTPase activity;GO:0045134|uridine-diphosphatase activity;","K14643","ENTPD7; ectonucleoside triphosphate diphosphohydrolase 7 [EC:3.6.1.-]"]
["ENSRNOG00000052634",22,1.85097591,68,4.374469797,0.423131487,-1.240822048,0.000145109,1.28701E-4,"down","yes","Lsmem2","protein_coding","chr8:108266345-108279115:-","gi|121583784|ref|NP_001073411.1|",3783,0,"semaphorin-3B precursor [Rattus norvegicus]","gi|672063083|ref|XM_008766551.1|",2747,0,"PREDICTED: Rattus norvegicus sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B (Sema3b), transcript variant X3, mRNA","Q62177",1374,0,"Semaphorin-3B",".",".",".",".","pfam01403","Sema","Sema domain. The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and human plexin A-3.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000066003",22,1.85097591,68,4.374469797,0.423131487,-1.240822048,0.000145109,1.28701E-4,"down","yes","ENSRNOG00000066003","lncRNA","chr11:57057469-57072716:-",".",".",".",".","gi|55416049|gb|AC120871.12|",921,0,"Mus musculus chromosome 16, clone RP23-121E8, complete sequence",".",".",".",".",".",".",".",".","pfam01529","zf-DHHC","DHHC palmitoyltransferase. This family includes the well known DHHC zinc binding domain as well as three of the four conserved transmembrane regions found in this family of palmitoyltransferase enzymes.",".",".",".",".","."]
["ENSRNOG00000003443",5,0.420676343,30,1.929913146,0.217976827,-2.197753326,0.000152656,1.3489E-4,"down","yes","Klf1","protein_coding","chr19:23250631-23253758:-","gi|157820761|ref|NP_001100634.1|",1589,0,"Krueppel-like factor 1 [Rattus norvegicus]","gi|298890131|emb|FQ233857.1|",1346,0,"Rattus norvegicus TL0AEA60YC05 mRNA sequence","P46099",543,0,"Krueppel-like factor 1",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0001701|in utero embryonic development;GO:0001889|liver development;GO:0006338|chromatin remodeling;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0010628|positive regulation of gene expression;GO:0030218|erythrocyte differentiation;GO:0035162|embryonic hemopoiesis;GO:0043249|erythrocyte maturation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048821|erythrocyte development;GO:0060135|maternal process involved in female pregnancy;GO:1901653|cellular response to peptide;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987|proximal promoter sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0019904|protein domain specific binding;","K09204","KLF1; krueppel-like factor 1"]
["ENSRNOG00000054019",5,0.420676343,30,1.929913146,0.217976827,-2.197753326,0.000152656,1.3489E-4,"down","yes","SNORA72","snoRNA","chr7:65648758-65648889:-",".",".",".",".","gi|298892028|emb|FQ220874.1|",132,{"v":1E-61,"d":"1.00E-61"},"Rattus norvegicus TL0ADA41YF23 mRNA sequence",".",".",".",".",".",".",".",".","pfam09471","Peptidase_M64","IgA Peptidase M64. This is a family of highly selective metallo-endopeptidases. The primary structure of the Clostridium ramosum IgA proteinase shows no significant overall similarity to any other known metallo-endopeptidase.",".",".",".",".","."]
["ENSRNOG00000017982",9,0.757217418,40,2.573217527,0.294268716,-1.764793919,0.000153903,0.000135837,"down","yes","Pnliprp2","protein_coding","chr1:257897766-257916434:+","gi|17105374|ref|NP_476554.1|",2597,0,"pancreatic lipase-related protein 2 precursor [Rattus norvegicus]","gi|17105373|ref|NM_057206.1|",1536,0,"Rattus norvegicus pancreatic lipase related protein 2 (Pnliprp2), mRNA","P54318",976,0,"Pancreatic lipase-related protein 2",".",".",".",".","pfam00151","Lipase","Lipase.","GO:0006644|phospholipid metabolic process;GO:0006968|cellular defense response;GO:0009395|phospholipid catabolic process;GO:0009617|response to bacterium;GO:0009791|post-embryonic development;GO:0016042|lipid catabolic process;GO:0019376|galactolipid catabolic process;GO:0019433|triglyceride catabolic process;GO:0032094|response to food;GO:0033993|response to lipid;GO:0034638|phosphatidylcholine catabolic process;GO:0043434|response to peptide hormone;GO:0044258|intestinal lipid catabolic process;GO:0051384|response to glucocorticoid;","GO:0005615|extracellular space;GO:0042589|zymogen granule membrane;GO:0043005|neuron projection;","GO:0004620|phospholipase activity;GO:0004806|triglyceride lipase activity;GO:0005509|calcium ion binding;GO:0016298|lipase activity;GO:0047372|acylglycerol lipase activity;GO:0047714|galactolipase activity;GO:0102549|1-18:1-2-16:0-monogalactosyldiacylglycerol lipase activity;","K14075","PNLIPRP2, PLRP2; pancreatic lipase-related protein 2 [EC:3.1.1.3]"]
["ENSRNOG00000020484",33,2.776463865,89,5.725408998,0.48493721,-1.044130137,1.5411E-4,0.000135998,"down","yes","Trpm5","protein_coding","chr1:198255723-198277654:-","gi|672039451|ref|XP_008758382.1|",6111,0,"PREDICTED: transient receptor potential cation channel subfamily M member 5 isoform X1 [Rattus norvegicus]","gi|300798669|ref|NM_001191896.1|",3471,0,"Rattus norvegicus transient receptor potential cation channel, subfamily M, member 5 (Trpm5), mRNA","Q9JJH7",2234,0,"Transient receptor potential cation channel subfamily M member 5",".",".",".",".","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0019722|calcium-mediated signaling;GO:0034220|ion transmembrane transport;GO:0035725|sodium ion transmembrane transport;GO:0050909|sensory perception of taste;GO:0070588|calcium ion transmembrane transport;GO:0071805|potassium ion transmembrane transport;GO:0098655|cation transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0030425|dendrite;GO:0043025|neuronal cell body;","GO:0005227|calcium activated cation channel activity;GO:0005261|cation channel activity;GO:0005267|potassium channel activity;GO:0005272|sodium channel activity;GO:0099604|ligand-gated calcium channel activity;","K04980","TRPM5; transient receptor potential cation channel subfamily M member 5"]
["ENSRNOG00000059622",13,1.093758492,49,3.152191471,0.34698352,-1.527060951,0.000158704,1.39825E-4,"down","yes","Pigb","protein_coding","chr8:73751798-73775679:-","gi|294862231|ref|NP_001101636.3|",2736,0,"GPI mannosyltransferase 3 [Rattus norvegicus]","gi|294862230|ref|NM_001108166.3|",2189,0,"Rattus norvegicus phosphatidylinositol glycan anchor biosynthesis, class B (Pigb), mRNA","Q9JJQ0",974,0,"GPI mannosyltransferase 3",".",".",".",".","pfam03901","Glyco_transf_22","Alg9-like mannosyltransferase family. Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.","GO:0006506|GPI anchor biosynthetic process;GO:0097502|mannosylation;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0000026|alpha-1,2-mannosyltransferase activity;GO:0000030|mannosyltransferase activity;GO:0004376|glycolipid mannosyltransferase activity;","K05286","PIGB; GPI mannosyltransferase 3 [EC:2.4.1.-]"]
["ENSRNOG00000067655",13,1.093758492,49,3.152191471,0.34698352,-1.527060951,0.000158704,1.39825E-4,"down","yes","ENSRNOG00000067655","protein_coding","chr1:181402275-181417714:-","gi|795122734|ref|XP_011788908.1|",2276,0,"PREDICTED: LOW QUALITY PROTEIN: fructose-bisphosphate aldolase A [Colobus angolensis palliatus]","gi|672038362|ref|XM_006230209.2|",1453,0,"PREDICTED: Rattus norvegicus aldolase A, fructose-bisphosphate (Aldoa), transcript variant X2, mRNA","P05065",717,0,"Fructose-bisphosphate aldolase A","AGl2190",322,{"v":1E-100,"d":"1.00E-100"},"COG3588","pfam00274","Glycolytic","Fructose-bisphosphate aldolase class-I.",".",".",".",".","."]
["ENSRNOG00000060293",31,2.608193328,85,5.468087246,0.476984585,-1.067985451,1.65074E-4,0.000145015,"down","yes","Ndufa3","protein_coding","chr1:65597578-65600235:-","gi|564296738|ref|XP_002725549.2|",301,{"v":9e-29,"d":"9.00E-29"},"PREDICTED: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [Rattus norvegicus]","gi|34368610|gb|AC103574.7|",2098,0,"Rattus norvegicus 1 BAC CH230-205C19 (Children's Hospital Oakland Research Institute) complete sequence","Q9CQ91",113,{"v":5e-28,"d":"5.00E-28"},"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3",".",".",".",".","pfam14987","NADHdh_A3","NADH dehydrogenase 1 alpha subcomplex subunit 3. This family of proteins are accessory subunits of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). This subunit is not believed to be catalytic.","GO:0032981|mitochondrial respiratory chain complex I assembly;","GO:0005747|mitochondrial respiratory chain complex I;",".","K03947","NDUFA3; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 3"]
["ENSRNOG00000004946",2,0.168270537,21,1.350939202,0.124558187,-3.005108248,0.000165584,1.45439E-4,"down","yes","Cst12","protein_coding","chr3:136235041-136238909:+","gi|149041155|gb|EDL95088.1|",687,{"v":1E-89,"d":"1.00E-89"},"cystatin TE-1, isoform CRA_b [Rattus norvegicus]","gi|24308501|ref|NM_153734.1|",517,0,"Rattus norvegicus cystatin 12 (Cst12), mRNA","Q8VII2",261,{"v":5e-88,"d":"5.00E-88"},"Cystatin-12",".",".",".",".","pfam00031","Cystatin","Cystatin domain. Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 are related to this family but have not been included.","GO:0010951|negative regulation of endopeptidase activity;","GO:0005576|extracellular region;","GO:0004869|cysteine-type endopeptidase inhibitor activity;",".","."]
["ENSRNOG00000066755",14,1.177893761,51,3.280852347,0.359020656,-1.477861245,0.000169146,0.00014844,"down","yes","ENSRNOG00000066755","protein_coding","chr6:16144204-16145608:+","gi|589935503|ref|XP_006980523.1|",1567,0,"PREDICTED: heterogeneous nuclear ribonucleoprotein F-like [Peromyscus maniculatus bairdii]","gi|672055185|ref|XR_354487.2|",712,0,"PREDICTED: Rattus norvegicus similar to heterogeneous nuclear ribonucleoprotein F (LOC679604), transcript variant X2, misc_RNA","Q794E4",607,0,"Heterogeneous nuclear ribonucleoprotein F",".",".",".",".","pfam14259","RRM_6","RNA recognition motif (a.k.a. RRM, RBD, or RNP domain).",".",".",".",".","."]
["ENSRNOG00000012878",15,1.26202903,53,3.409513224,0.370149328,-1.433820684,0.00017796,0.000155732,"down","yes","Atp7b","protein_coding","chr16:69951778-70023636:+","gi|564389728|ref|XP_006253408.1|",7593,0,"PREDICTED: copper-transporting ATPase 2 isoform X1 [Rattus norvegicus]","gi|672080488|ref|XM_006253346.2|",6182,0,"PREDICTED: Rattus norvegicus ATPase, Cu++ transporting, beta polypeptide (Atp7b), transcript variant X1, mRNA","Q64535",2794,0,"Copper-transporting ATPase 2","SA2344",605,0,"COG2217","pfam00122","E1-E2_ATPase","E1-E2 ATPase.","GO:0006825|copper ion transport;GO:0006878|cellular copper ion homeostasis;GO:0006882|cellular zinc ion homeostasis;GO:0007595|lactation;GO:0007623|circadian rhythm;GO:0010043|response to zinc ion;GO:0015677|copper ion import;GO:0015680|protein maturation by copper ion transfer;GO:0035434|copper ion transmembrane transport;GO:0046688|response to copper ion;GO:0051208|sequestering of calcium ion;GO:0051591|response to cAMP;GO:0055070|copper ion homeostasis;GO:0060003|copper ion export;GO:0071280|cellular response to copper ion;GO:0071287|cellular response to manganese ion;GO:1990637|response to prolactin;","GO:0005770|late endosome;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005802|trans-Golgi network;GO:0005886|plasma membrane;GO:0005923|bicellular tight junction;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0031410|cytoplasmic vesicle;GO:0032588|trans-Golgi network membrane;GO:0045177|apical part of cell;GO:0048471|perinuclear region of cytoplasm;GO:0070160|tight junction;","GO:0005375|copper ion transmembrane transporter activity;GO:0005507|copper ion binding;GO:0005524|ATP binding;GO:0008270|zinc ion binding;GO:0043682|copper-transporting ATPase activity;","K17686","copA, ctpA, ATP7; P-type Cu+ transporter [EC:7.2.2.8]"]
["ENSRNOG00000031391",3,0.252405806,24,1.543930516,0.16348262,-2.612790825,1.78875E-4,0.000156483,"down","yes","Ceacam16","protein_coding","chr1:79514975-79524871:-","gi|391738042|sp|D3ZQE1.1|CEA16_RAT",2072,0,"RecName: Full=Carcinoembryonic antigen-related cell adhesion molecule 16; Flags: Precursor","gi|281371399|ref|NM_001169579.1|",1615,0,"Rattus norvegicus carcinoembryonic antigen-related cell adhesion molecule 16 (Ceacam16), mRNA","D3ZQE1",802,0,"Carcinoembryonic antigen-related cell adhesion molecule 16",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0007605|sensory perception of sound;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0032426|stereocilium tip;","GO:0003674|molecular_function;GO:0042802|identical protein binding;","K06499","CEACAM, CD66; carcinoembryonic antigen-related cell adhesion molecule"]
["ENSRNOG00000066293",35,2.944734403,92,5.918400313,0.4975558,-1.007069764,0.000187755,1.63778E-4,"down","yes","ENSRNOG00000066293","lncRNA","chr19:13740964-13768610:-","gi|672033587|ref|XP_008756475.1|",339,{"v":1e-34,"d":"1.00E-34"},"PREDICTED: uncharacterized protein LOC501421 isoform X1 [Rattus norvegicus]","gi|425703057|gb|AC246664.5|",604,0,"Rattus norvegicus Y Chr BAC RNAEX-360A21 (Amplicon Express Rat SHR-Akr BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam09727","CortBP2","Cortactin-binding protein-2. This entry is the first approximately 250 residues of cortactin-binding protein 2. In addition to being a positional candidate for autism this protein is expressed at highest levels in the brain in humans. The human protein has six associated ankyrin repeat domains pfam00023 towards the C-terminus which act as protein-protein interaction domains.",".",".",".",".","."]
["ENSRNOG00000069271",35,2.944734403,92,5.918400313,0.4975558,-1.007069764,0.000187755,1.63778E-4,"down","yes","Ttn","protein_coding","chr3:61652439-61924741:-","gi|568916277|ref|XP_006499220.1|",113692,0,"PREDICTED: titin isoform X1 [Mus musculus]","gi|755499200|ref|XM_006499157.2|",58475,0,"PREDICTED: Mus musculus titin (Ttn), transcript variant X1, mRNA","A2ASS6",43740,0,"Titin",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.",".",".",".",".","."]
["ENSRNOG00000000860",19,1.598570104,61,3.924156729,0.407366529,-1.295600649,0.000197812,0.000172136,"down","yes","Vwa7","protein_coding","chr20:3794991-3805525:-","gi|47059189|ref|NP_997664.1|",3950,0,"von Willebrand factor A domain-containing protein 7 precursor [Rattus norvegicus]","gi|164518926|ref|NM_212499.2|",4344,0,"Rattus norvegicus von Willebrand factor A domain containing 7 (Vwa7), mRNA","Q6MG64",1524,0,"von Willebrand factor A domain-containing protein 7",".",".",".",".","pfam13519","VWA_2","von Willebrand factor type A domain.",".","GO:0005576|extracellular region;",".","K24511","VWA7; von Willebrand factor A domain-containing protein 7"]
["ENSRNOG00000014761",8,0.673082149,37,2.380226213,0.282780748,-1.822244191,0.000198234,0.000172448,"down","yes","Rasd2","protein_coding","chr19:13594291-13605016:+","gi|537193698|gb|ERE77608.1|",1808,0,"GTP-binding protein Rhes-like protein [Cricetulus griseus]","gi|21717662|ref|NM_133568.1|",3445,0,"Rattus norvegicus RASD family, member 2 (Rasd2), mRNA","P63033",561,0,"GTP-binding protein Rhes",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0001963|synaptic transmission, dopaminergic;GO:0007626|locomotory behavior;GO:0031397|negative regulation of protein ubiquitination;GO:0033235|positive regulation of protein sumoylation;GO:0043949|regulation of cAMP-mediated signaling;GO:0051897|positive regulation of protein kinase B signaling;","GO:0005886|plasma membrane;GO:0045202|synapse;","GO:0003924|GTPase activity;GO:0005515|protein binding;GO:0005525|GTP binding;GO:0031624|ubiquitin conjugating enzyme binding;GO:0031681|G-protein beta-subunit binding;GO:0043548|phosphatidylinositol 3-kinase binding;","K07844","RASD2; RASD family, member 2"]
["ENSRNOG00000014870",6,0.504811612,32,2.058574022,0.24522393,-2.027828325,2.02122E-4,0.00017569,"down","yes","Slc13a5","protein_coding","chr10:56866249-56890945:-","gi|564372546|ref|XP_006246664.1|",2975,0,"PREDICTED: solute carrier family 13 member 5 isoform X1 [Rattus norvegicus]","gi|672067721|ref|XM_006246602.2|",3501,0,"PREDICTED: Rattus norvegicus solute carrier family 13 (sodium-dependent citrate transporter), member 5 (Slc13a5), transcript variant X1, mRNA","Q8CJ44",1047,0,"Solute carrier family 13 member 5","SA1732",238,{"v":1e-66,"d":"1.00E-66"},"COG0471","pfam00939","Na_sulph_symp","Sodium:sulfate symporter transmembrane region. There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.","GO:0006814|sodium ion transport;GO:0006842|tricarboxylic acid transport;GO:0015729|oxaloacetate transport;GO:0015741|fumarate transport;GO:0015742|alpha-ketoglutarate transport;GO:0015744|succinate transport;GO:0015746|citrate transport;GO:0035674|tricarboxylic acid transmembrane transport;GO:0071285|cellular response to lithium ion;GO:0071422|succinate transmembrane transport;GO:0098656|anion transmembrane transport;","GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;","GO:0005343|organic acid:sodium symporter activity;GO:0015137|citrate transmembrane transporter activity;GO:0015141|succinate transmembrane transporter activity;GO:0015142|tricarboxylic acid transmembrane transporter activity;GO:0017153|sodium:dicarboxylate symporter activity;","K14445","SLC13A2_3_5; solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2/3/5"]
["ENSRNOG00000030104",6,0.504811612,32,2.058574022,0.24522393,-2.027828325,2.02122E-4,0.00017569,"down","yes","Vom2r44","protein_coding","chr2:148500170-148531880:+","gi|564336661|ref|XP_006232500.1|",4745,0,"PREDICTED: vomeronasal type-2 receptor 1 isoform X1 [Rattus norvegicus]","gi|672042496|ref|XM_006232438.2|",2903,0,"PREDICTED: Rattus norvegicus vomeronasal 2 receptor 44 (Vom2r44), transcript variant X1, mRNA","O70410",1705,0,"Vomeronasal type-2 receptor 1",".",".",".",".","pfam00003","7tm_3","7 transmembrane sweet-taste receptor of 3 GCPR. This is a domain of seven transmembrane regions that forms the C-terminus of some subclass 3 G-coupled-protein receptors. It is often associated with a downstream cysteine-rich linker domain, NCD3G pfam07562, which is the human sweet-taste receptor, and the N-terminal domain, ANF_receptor pfam01094. The seven TM regions assemble in such a way as to produce a docking pocket into which such molecules as cyclamate and lactisole have been found to bind and consequently confer the taste of sweetness.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0050911|detection of chemical stimulus involved in sensory perception of smell;","GO:0005887|integral component of plasma membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004984|olfactory receptor activity;","K04613","V2R; vomeronasal 2 receptor"]
["ENSRNOG00000004639",33,2.776463865,88,5.66107856,0.49044786,-1.027828325,2.03399E-4,0.000176743,"down","yes","Traf6","protein_coding","chr3:87963514-87983507:+","gi|157820501|ref|NP_001101224.1|",2724,0,"TNF receptor-associated factor 6 [Rattus norvegicus]","gi|197927342|ref|NM_001107754.2|",2540,0,"Rattus norvegicus TNF receptor associated factor 6 (Traf6), mRNA","B5DF45",1053,0,"TNF receptor-associated factor 6",".",".",".",".","pfam02176","zf-TRAF","TRAF-type zinc finger.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0000209|protein polyubiquitination;GO:0001503|ossification;GO:0001701|in utero embryonic development;GO:0001843|neural tube closure;GO:0002637|regulation of immunoglobulin production;GO:0002726|positive regulation of T cell cytokine production;GO:0006955|immune response;GO:0006974|cellular response to DNA damage stimulus;GO:0007165|signal transduction;GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0007250|activation of NF-kappaB-inducing kinase activity;GO:0007254|JNK cascade;GO:0009887|animal organ morphogenesis;GO:0016567|protein ubiquitination;GO:0019221|cytokine-mediated signaling pathway;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030316|osteoclast differentiation;GO:0031666|positive regulation of lipopolysaccharide-mediated signaling pathway;GO:0032147|activation of protein kinase activity;GO:0032735|positive regulation of interleukin-12 production;GO:0032743|positive regulation of interleukin-2 production;GO:0032755|positive regulation of interleukin-6 production;GO:0033209|tumor necrosis factor-mediated signaling pathway;GO:0042088|T-helper 1 type immune response;GO:0042102|positive regulation of T cell proliferation;GO:0042475|odontogenesis of dentin-containing tooth;GO:0042981|regulation of apoptotic process;GO:0043011|myeloid dendritic cell differentiation;GO:0043122|regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043507|positive regulation of JUN kinase activity;GO:0045453|bone resorption;GO:0045672|positive regulation of osteoclast differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046330|positive regulation of JNK cascade;GO:0046849|bone remodeling;GO:0048468|cell development;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0050852|T cell receptor signaling pathway;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051865|protein autoubiquitination;GO:0070498|interleukin-1-mediated signaling pathway;GO:0070534|protein K63-linked ubiquitination;GO:0070555|response to interleukin-1;GO:0071222|cellular response to lipopolysaccharide;GO:0071345|cellular response to cytokine stimulus;GO:0097400|interleukin-17-mediated signaling pathway;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1904996|positive regulation of leukocyte adhesion to vascular endothelial cell;GO:2000679|positive regulation of transcription regulatory region DNA binding;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005811|lipid droplet;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005938|cell cortex;GO:0009898|cytoplasmic side of plasma membrane;GO:0032991|protein-containing complex;GO:0035631|CD40 receptor complex;GO:0048471|perinuclear region of cytoplasm;GO:0098802|plasma membrane receptor complex;","GO:0004842|ubiquitin-protein transferase activity;GO:0005164|tumor necrosis factor receptor binding;GO:0008270|zinc ion binding;GO:0019901|protein kinase binding;GO:0031435|mitogen-activated protein kinase kinase kinase binding;GO:0031624|ubiquitin conjugating enzyme binding;GO:0031625|ubiquitin protein ligase binding;GO:0031996|thioesterase binding;GO:0032813|tumor necrosis factor receptor superfamily binding;GO:0042802|identical protein binding;GO:0042826|histone deacetylase binding;GO:0043422|protein kinase B binding;GO:0047485|protein N-terminus binding;GO:0061630|ubiquitin protein ligase activity;","K03175","TRAF6; TNF receptor-associated factor 6 [EC:2.3.2.27]"]
["ENSRNOG00000007378",1,0.084135269,17,1.093617449,0.076932998,-3.700253667,0.00021631,0.000187454,"down","yes","Acox2","protein_coding","chr15:16660272-16692160:+","gi|564385630|ref|XP_006251805.1|",3788,0,"PREDICTED: peroxisomal acyl-coenzyme A oxidase 2 isoform X2 [Rattus norvegicus]","gi|672077431|ref|XM_006251743.2|",2363,0,"PREDICTED: Rattus norvegicus acyl-CoA oxidase 2, branched chain (Acox2), transcript variant X1, mRNA","P97562",1419,0,"Peroxisomal acyl-coenzyme A oxidase 2","YGL205w",256,{"v":2e-71,"d":"2.00E-71"},"COG1960","pfam01756","ACOX","Acyl-CoA oxidase. This is a family of Acyl-CoA oxidases EC:1.3.3.6. Acyl-coA oxidase converts acyl-CoA into trans-2- enoyl-CoA.","GO:0000038|very long-chain fatty acid metabolic process;GO:0006631|fatty acid metabolic process;GO:0006635|fatty acid beta-oxidation;GO:0010942|positive regulation of cell death;GO:0033540|fatty acid beta-oxidation using acyl-CoA oxidase;GO:0055088|lipid homeostasis;GO:1902884|positive regulation of response to oxidative stress;","GO:0005777|peroxisome;GO:0005829|cytosol;GO:0043231|intracellular membrane-bounded organelle;","GO:0003997|acyl-CoA oxidase activity;GO:0005504|fatty acid binding;GO:0016401|palmitoyl-CoA oxidase activity;GO:0033791|3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity;GO:0050660|flavin adenine dinucleotide binding;GO:0071949|FAD binding;","K10214","ACOX2; 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase [EC:1.17.99.3]"]
["ENSRNOG00000045816",1,0.084135269,17,1.093617449,0.076932998,-3.700253667,0.00021631,0.000187454,"down","yes","Gria1","protein_coding","chr10:41210713-41527283:+","gi|34328128|ref|NP_032191.2|",4637,0,"glutamate receptor 1 isoform 2 precursor [Mus musculus]","gi|29789268|ref|NM_031608.1|",2965,0,"Rattus norvegicus glutamate ionotropic receptor AMPA type subunit 1 (Gria1), mRNA","P19490",1791,0,"Glutamate receptor 1",".",".",".",".","pfam00060","Lig_chan","Ligand-gated ion channel. This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.","GO:0001919|regulation of receptor recycling;GO:0007268|chemical synaptic transmission;GO:0007616|long-term memory;GO:0009410|response to xenobiotic stimulus;GO:0009636|response to toxic substance;GO:0010226|response to lithium ion;GO:0014070|response to organic cyclic compound;GO:0019228|neuronal action potential;GO:0021510|spinal cord development;GO:0031623|receptor internalization;GO:0032355|response to estradiol;GO:0034220|ion transmembrane transport;GO:0035235|ionotropic glutamate receptor signaling pathway;GO:0035249|synaptic transmission, glutamatergic;GO:0042220|response to cocaine;GO:0043434|response to peptide hormone;GO:0045838|positive regulation of membrane potential;GO:0046685|response to arsenic-containing substance;GO:0048167|regulation of synaptic plasticity;GO:0050804|modulation of chemical synaptic transmission;GO:0050806|positive regulation of synaptic transmission;GO:0051602|response to electrical stimulus;GO:0060078|regulation of postsynaptic membrane potential;GO:0060292|long-term synaptic depression;GO:0060992|response to fungicide;GO:0071230|cellular response to amino acid stimulus;GO:0071242|cellular response to ammonium ion;GO:0071359|cellular response to dsRNA;GO:0071363|cellular response to growth factor stimulus;GO:0071375|cellular response to peptide hormone stimulus;GO:0071407|cellular response to organic cyclic compound;GO:0071418|cellular response to amine stimulus;GO:0099566|regulation of postsynaptic cytosolic calcium ion concentration;","GO:0005769|early endosome;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0008021|synaptic vesicle;GO:0008328|ionotropic glutamate receptor complex;GO:0009986|cell surface;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0030672|synaptic vesicle membrane;GO:0031594|neuromuscular junction;GO:0031901|early endosome membrane;GO:0032279|asymmetric synapse;GO:0032281|AMPA glutamate receptor complex;GO:0032590|dendrite membrane;GO:0032591|dendritic spine membrane;GO:0032991|protein-containing complex;GO:0036477|somatodendritic compartment;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043197|dendritic spine;GO:0043198|dendritic shaft;GO:0044297|cell body;GO:0044308|axonal spine;GO:0044309|neuron spine;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0055037|recycling endosome;GO:0055038|recycling endosome membrane;GO:0060076|excitatory synapse;GO:0097060|synaptic membrane;GO:0098794|postsynapse;GO:0098839|postsynaptic density membrane;GO:0098978|glutamatergic synapse;GO:0099055|integral component of postsynaptic membrane;GO:0099056|integral component of presynaptic membrane;GO:0099061|integral component of postsynaptic density membrane;GO:0099544|perisynaptic space;","GO:0001540|amyloid-beta binding;GO:0001965|G-protein alpha-subunit binding;GO:0004970|ionotropic glutamate receptor activity;GO:0004971|AMPA glutamate receptor activity;GO:0005515|protein binding;GO:0008022|protein C-terminus binding;GO:0008179|adenylate cyclase binding;GO:0015276|ligand-gated ion channel activity;GO:0019865|immunoglobulin binding;GO:0019901|protein kinase binding;GO:0019904|protein domain specific binding;GO:0030165|PDZ domain binding;GO:0031267|small GTPase binding;GO:0031489|myosin V binding;GO:0031681|G-protein beta-subunit binding;GO:0031698|beta-2 adrenergic receptor binding;GO:0035254|glutamate receptor binding;GO:0038023|signaling receptor activity;GO:0042802|identical protein binding;GO:0051018|protein kinase A binding;GO:0097110|scaffold protein binding;GO:0099583|neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration;GO:1904315|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K05197","GRIA1; glutamate receptor 1"]
["ENSRNOG00000051399",1,0.084135269,17,1.093617449,0.076932998,-3.700253667,0.00021631,0.000187454,"down","yes","Col10a1","protein_coding","chr20:38182494-38189494:+","gi|4090263|emb|CAA10518.1|",869,{"v":2e-104,"d":"2.00E-104"},"collagen alpha 1 type X [Rattus norvegicus]","gi|672086734|ref|XM_001053056.6|",3172,0,"PREDICTED: Rattus norvegicus collagen, type X, alpha 1 (Col10a1), transcript variant X2, mRNA","Q05306",333,{"v":1e-98,"d":"1.00E-98"},"Collagen alpha-1(X) chain",".",".",".",".","pfam00386","C1q","C1q domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.","GO:0001958|endochondral ossification;GO:0051216|cartilage development;","GO:0005581|collagen trimer;GO:0005938|cell cortex;GO:0031012|extracellular matrix;GO:0062023|collagen-containing extracellular matrix;","GO:0003674|molecular_function;","K19479","COL10A; collagen type X alpha"]
["ENSRNOG00000058906",1,0.084135269,17,1.093617449,0.076932998,-3.700253667,0.00021631,0.000187454,"down","yes","Ptprh","protein_coding","chr1:69242321-69285077:+","gi|300794452|ref|NP_001178874.1|",4371,0,"receptor-type tyrosine-protein phosphatase H precursor [Rattus norvegicus]","gi|672034916|ref|XM_008758887.1|",2272,0,"PREDICTED: Rattus norvegicus protein tyrosine phosphatase, receptor type, H (Ptprh), transcript variant X1, mRNA","E9Q0N2",1371,0,"Receptor-type tyrosine-protein phosphatase H","SPAC11E3.09",129,{"v":7e-31,"d":"7.00E-31"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:1990264|peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity;","GO:0005902|microvillus;GO:0016021|integral component of membrane;","GO:0005001|transmembrane receptor protein tyrosine phosphatase activity;GO:0045296|cadherin binding;","K18034","PTPRH, SAP1; receptor-type tyrosine-protein phosphatase H [EC:3.1.3.48]"]
["ENSRNOG00000063038",1,0.084135269,17,1.093617449,0.076932998,-3.700253667,0.00021631,0.000187454,"down","yes","ENSRNOG00000063038","protein_coding","chr17:54151623-54154198:+","gi|564319956|ref|XP_001057382.3|",1276,{"v":1E-173,"d":"1.00E-173"},"PREDICTED: ral guanine nucleotide dissociation stimulator-like [Rattus norvegicus]","gi|672082209|ref|XM_341541.7|",1164,0,"PREDICTED: Rattus norvegicus similar to hypothetical protein 4930474N05 (RGD1564129), transcript variant X2, mRNA","Q03386",109,{"v":2e-24,"d":"2.00E-24"},"Ral guanine nucleotide dissociation stimulator",".",".",".",".","pfam00618","RasGEF_N","RasGEF N-terminal motif. A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this motif/domain N-terminal to the RasGef (Cdc25-like) domain.",".",".",".",".","."]
["ENSRNOG00000000499",30,2.524058059,82,5.275095931,0.478485717,-1.063452234,0.000226616,0.0001957,"down","yes","Tcp11","protein_coding","chr20:6126269-6136055:-","gi|56090245|ref|NP_001007696.1|",2625,0,"T-complex protein 11 homolog [Rattus norvegicus]","gi|56090244|ref|NM_001007695.1|",1909,0,"Rattus norvegicus t-complex protein 11 (Tcp11), mRNA","Q5XI00",1015,0,"T-complex protein 11 homolog",".",".",".",".","pfam05794","Tcp11","T-complex protein 11. This family consists of several eukaryotic T-complex protein 11 (Tcp11) related sequences. Tcp11 is only expressed in fertile adult mammalian testes and is thought to be important in sperm function and fertility. The family also contains the yeast Sok1 protein which is known to suppress cyclic AMP-dependent protein kinase mutants.","GO:0007165|signal transduction;GO:0007283|spermatogenesis;GO:0010737|protein kinase A signaling;GO:0030154|cell differentiation;GO:0043949|regulation of cAMP-mediated signaling;GO:0045920|negative regulation of exocytosis;GO:1902490|regulation of sperm capacitation;","GO:0001669|acrosomal vesicle;GO:0016021|integral component of membrane;GO:0036126|sperm flagellum;GO:0097225|sperm midpiece;",".","K25628","TCP11; T-complex protein 11"]
["ENSRNOG00000010758",13,1.093758492,48,3.087861033,0.354212343,-1.497313608,2.29223E-4,0.000197795,"down","yes","Lpar2","protein_coding","chr16:19595655-19599998:-","gi|40254539|ref|NP_064412.2|",1379,0,"lysophosphatidic acid receptor 2 [Mus musculus]","gi|157818488|ref|NM_001109109.1|",1612,0,"Rattus norvegicus lysophosphatidic acid receptor 2 (Lpar2), mRNA","Q9HBW0",505,{"v":4E-175,"d":"4.00E-175"},"Lysophosphatidic acid receptor 2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0019222|regulation of metabolic process;GO:0035025|positive regulation of Rho protein signal transduction;GO:0043410|positive regulation of MAPK cascade;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0030139|endocytic vesicle;GO:0098978|glutamatergic synapse;GO:0099059|integral component of presynaptic active zone membrane;","GO:0004930|G protein-coupled receptor activity;GO:0030165|PDZ domain binding;GO:0070915|lysophosphatidic acid receptor activity;","K04291","LPAR2, EDG4; lysophosphatidic acid receptor 2"]
["ENSRNOG00000064312",9,0.757217418,39,2.508887089,0.301814068,-1.728268043,2.30533E-4,0.000198799,"down","yes","ENSRNOG00000064312","lncRNA","chr8:118235396-118241659:+","gi|300797432|ref|NP_001178009.1|",286,{"v":3e-46,"d":"3.00E-46"},"golgin subfamily A member 4 [Rattus norvegicus]","gi|672063646|ref|XM_006244133.2|",380,0,"PREDICTED: Rattus norvegicus golgin A4 (Golga4), transcript variant X8, mRNA","Q5U4E6",114,{"v":3e-47,"d":"3.00E-47"},"Golgin subfamily A member 4",".",".",".",".","pfam15070","GOLGA2L5","Putative golgin subfamily A member 2-like protein 5. The function of the GOLGA2L5 protein family remains unknown. This family of proteins is thought to be found in the Golgi apparatus of eukaryotes. Proteins in this family are typically between and 840 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000069775",9,0.757217418,39,2.508887089,0.301814068,-1.728268043,2.30533E-4,0.000198799,"down","yes","ENSRNOG00000069775","lncRNA","chr2:39508461-39526936:-",".",".",".",".","gi|672041438|ref|XR_590885.1|",1423,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102549347 (LOC102549347), transcript variant X4, ncRNA",".",".",".",".",".",".",".",".","pfam04388","Hamartin","Hamartin protein. This family includes the hamartin protein which is thought to function as a tumor suppressor. The hamartin protein interacts with the tuberin protein pfam03542. Tuberous sclerosis complex (TSC) is an autosomal dominant disorder and is characterized by the presence of hamartomas in many organs, such as brain, skin, heart, lung, and kidney. It is caused by mutation either TSC1 or TSC2 tumor suppressor gene. TSC1 encodes a protein, hamartin, containing two coiled-coil regions, which have been shown to mediate binding to tuberin. The TSC2 gene codes for tuberin pfam03542. These two proteins function within the same pathway(s) regulating cell cycle, cell growth, adhesion, and vesicular trafficking.",".",".",".",".","."]
["ENSRNOG00000005936",0,0.042067634,15,0.964956573,0.043595365,-4.519681421,0.000231032,1.99135E-4,"down","yes","Foxm1","protein_coding","chr4:161638816-161650684:+","gi|564349102|ref|XP_006237479.1|",3437,0,"PREDICTED: forkhead box protein M1 isoform X2 [Rattus norvegicus]","gi|672051236|ref|XM_006237421.2|",3349,0,"PREDICTED: Rattus norvegicus forkhead box M1 (Foxm1), transcript variant X6, mRNA","P97691",1318,0,"Forkhead box protein M1","YCR065w",87.8,{"v":8e-17,"d":"8.00E-17"},"COG5025","pfam00250","Fork_head","Fork head domain.","GO:0000086|G2/M transition of mitotic cell cycle;GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001570|vasculogenesis;GO:0001889|liver development;GO:0006281|DNA repair;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;GO:0008284|positive regulation of cell proliferation;GO:0032873|negative regulation of stress-activated MAPK cascade;GO:0034698|response to gonadotropin;GO:0042127|regulation of cell proliferation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046578|regulation of Ras protein signal transduction;GO:0051591|response to cAMP;GO:0051726|regulation of cell cycle;GO:0090344|negative regulation of cell aging;GO:2000377|regulation of reactive oxygen species metabolic process;GO:2000781|positive regulation of double-strand break repair;","GO:0005575|cellular_component;GO:0005634|nucleus;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0019901|protein kinase binding;GO:0043565|sequence-specific DNA binding;","K09406","FOXM; forkhead box protein M"]
["ENSRNOG00000013519",0,0.042067634,15,0.964956573,0.043595365,-4.519681421,0.000231032,1.99135E-4,"down","yes","Tll2","protein_coding","chr1:239915508-240028120:-","gi|300798704|ref|NP_001178827.1|",5245,0,"tolloid-like protein 2 precursor [Rattus norvegicus]","gi|300798703|ref|NM_001191898.1|",3045,0,"Rattus norvegicus tolloid-like 2 (Tll2), mRNA","Q9WVM6",1959,0,"Tolloid-like protein 2",".",".",".",".","pfam01400","Astacin","Astacin (Peptidase family M12A). The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family contain two conserved disulphide bridges, these are joined 1-4 and 2-3. Members of this family have an amino terminal propeptide which is cleaved to give the active protease domain. All other linked domains are found to the carboxyl terminus of this domain. This family includes: Astacin, a digestive enzyme from Crayfish. Meprin, a multiple domain membrane component that is constructed from a homologous alpha and beta chain. Proteins involved in morphogenesis, and Tolloid from drosophila.","GO:0006508|proteolysis;GO:0030154|cell differentiation;GO:0048632|negative regulation of skeletal muscle tissue growth;",".","GO:0004222|metalloendopeptidase activity;GO:0005509|calcium ion binding;GO:0008270|zinc ion binding;","K13047","TLL2; tolloid-like protein 2 [EC:3.4.24.-]"]
["ENSRNOG00000013388",14,1.177893761,50,3.216521909,0.366201069,-1.449292093,2.42353E-4,2.08233E-4,"down","yes","Pgap1","protein_coding","chr9:55975667-56044464:-","gi|42538976|ref|NP_973719.1|",4700,0,"GPI inositol-deacylase [Rattus norvegicus]","gi|354458917|ref|NM_001163314.2|",2398,0,"Mus musculus post-GPI attachment to proteins 1 (Pgap1), mRNA","Q765A7",1815,0,"GPI inositol-deacylase",".",".",".",".","pfam07819","PGAP1","PGAP1-like protein. The sequences found in this family are similar to PGAP1. This is an endoplasmic reticulum membrane protein with a catalytic serine containing motif that is conserved in a number of lipases. PGAP1 functions as a GPI inositol-deacylase; this deacylation is important for the efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi body.","GO:0006505|GPI anchor metabolic process;GO:0006506|GPI anchor biosynthetic process;GO:0006888|ER to Golgi vesicle-mediated transport;GO:0007605|sensory perception of sound;GO:0009880|embryonic pattern specification;GO:0009948|anterior/posterior axis specification;GO:0015031|protein transport;GO:0021871|forebrain regionalization;GO:0060322|head development;GO:1902953|positive regulation of ER to Golgi vesicle-mediated transport;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0050185|phosphatidylinositol deacylase activity;","K05294","PGAP1; GPI inositol-deacylase [EC:3.-.-.-]"]
["ENSRNOG00000064826",14,1.177893761,50,3.216521909,0.366201069,-1.449292093,2.42353E-4,2.08233E-4,"down","yes","ENSRNOG00000064826","lncRNA","chr2:173598394-173604419:-","gi|149048159|gb|EDM00735.1|",228,{"v":5e-20,"d":"5.00E-20"},"rCG62570, partial [Rattus norvegicus]","gi|755505187|ref|XR_867419.1|",307,{"v":9E-158,"d":"9.00E-158"},"PREDICTED: Mus musculus uncharacterized LOC105244488 (LOC105244488), transcript variant X2, ncRNA",".",".",".",".",".",".",".",".","pfam12737","Mating_C","C-terminal domain of homeodomain 1. Mating in fungi is controlled by the loci that determine the mating type of an individual, and only individuals with differing mating types can mate. Basidiomycete fungi have evolved a unique mating system, termed tetrapolar or bifactorial incompatibility, in which mating type is determined by two unlinked loci; compatibility at both loci is required for mating to occur. The multi-allelic tetrapolar mating system is considered to be a novel innovation that could have only evolved once, and is thus unique to the mushroom fungi. This domain is C-terminal to the homeodomain transcription factor region.",".",".",".",".","."]
["ENSRNOG00000030726",17,1.430299567,56,3.602504538,0.39702922,-1.332682906,0.000267838,0.000228508,"down","yes","Asgr2","protein_coding","chr10:54821438-54834617:+","gi|8392926|ref|NP_058885.1|",763,{"v":1e-159,"d":"1.00E-159"},"asialoglycoprotein receptor 2 [Rattus norvegicus]","gi|7110515|gb|AF230645.1|AF230645",1447,0,"Rattus norvegicus testis-type galactosyl receptor mRNA, complete cds","P08290",298,{"v":5e-161,"d":"5.00E-161"},"Asialoglycoprotein receptor 2",".",".",".",".","pfam03954","Lectin_N","Hepatic lectin, N-terminal domain.","GO:0006897|endocytosis;GO:0009100|glycoprotein metabolic process;GO:0030282|bone mineralization;GO:0031647|regulation of protein stability;GO:0055088|lipid homeostasis;","GO:0016021|integral component of membrane;GO:0044322|endoplasmic reticulum quality control compartment;GO:0048471|perinuclear region of cytoplasm;","GO:0030246|carbohydrate binding;","K10064","ASGR2; asialoglycoprotein receptor 2"]
["ENSRNOG00000068265",19,1.598570104,60,3.859826291,0.414155971,-1.271753907,0.000274522,2.33771E-4,"down","yes","ENSRNOG00000068265","protein_coding","chr17:2931767-2958959:-","gi|564319318|ref|XP_006222365.1|",3335,0,"PREDICTED: zinc finger protein 431-like [Rattus norvegicus]","gi|672029634|ref|XM_008773616.1|",2139,0,"PREDICTED: Rattus norvegicus zinc finger protein 845-like (LOC102556556), mRNA","Q05481",924,0,"Zinc finger protein 91","SPAC144.09c",118,{"v":2e-27,"d":"2.00E-27"},"COG5048","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000066862",20,1.682705373,62,3.988487167,0.421890632,-1.245059041,0.000275272,0.000234373,"down","yes","ENSRNOG00000066862","protein_coding","chr1:116014375-116016228:-","gi|114145551|ref|NP_001041367.1|",1191,{"v":2e-154,"d":"2.00E-154"},"zinc finger CCCH domain-containing protein 11A [Rattus norvegicus]","gi|672013779|ref|XR_085718.4|",824,0,"PREDICTED: Rattus norvegicus similar to Zinc finger CCCH-type domain-containing protein 11A (LOC680017), transcript variant X1, misc_RNA","Q6NZF1",430,{"v":3e-143,"d":"3.00E-143"},"Zinc finger CCCH domain-containing protein 11A",".",".",".",".","pfam09533","DUF2380","Predicted lipoprotein of unknown function (DUF2380). This family consists of at least 9 paralogs in Myxococcus xanthus, a member of the Deltaproteobacteria. One appears truncated toward the N-terminus; the others are predicted lipoproteins. The function is unknown.",".",".",".",".","."]
["ENSRNOG00000022709",11,0.925487955,43,2.766208842,0.334569083,-1.579623961,0.000286903,0.000243552,"down","yes","AABR07046657.1","protein_coding","chr5:1451326-1453094:-","gi|564392471|ref|XP_006254406.1|",2383,0,"PREDICTED: acyl-CoA-binding domain-containing protein 5 isoform X2 [Rattus norvegicus]","gi|672018986|ref|XM_006225163.2|",1502,0,"PREDICTED: Rattus norvegicus similar to acyl-Coenzyme A binding domain containing 5 (LOC679565), mRNA","A0FKI7",915,0,"Acyl-CoA-binding domain-containing protein 5","RSc1366",62.4,{"v":9e-11,"d":"9.00E-11"},"COG4281","pfam00887","ACBP","Acyl CoA binding protein.",".",".",".",".","."]
["ENSRNOG00000003491",31,2.608193328,83,5.339426369,0.48847819,-1.033633946,2.89621E-4,2.45706E-4,"down","yes","Prkca","protein_coding","chr10:92894012-93288012:-","gi|157786690|ref|NP_001099183.1|",3451,0,"protein kinase C alpha type [Rattus norvegicus]","gi|157786689|ref|NM_001105713.1|",3702,0,"Rattus norvegicus protein kinase C, alpha (Prkca), mRNA","P05696",1316,0,"Protein kinase C alpha type",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0000302|response to reactive oxygen species;GO:0001525|angiogenesis;GO:0001933|negative regulation of protein phosphorylation;GO:0001934|positive regulation of protein phosphorylation;GO:0001938|positive regulation of endothelial cell proliferation;GO:0002026|regulation of the force of heart contraction;GO:0002062|chondrocyte differentiation;GO:0002159|desmosome assembly;GO:0006468|protein phosphorylation;GO:0006469|negative regulation of protein kinase activity;GO:0006874|cellular calcium ion homeostasis;GO:0006937|regulation of muscle contraction;GO:0007155|cell adhesion;GO:0007568|aging;GO:0007611|learning or memory;GO:0008285|negative regulation of cell proliferation;GO:0009612|response to mechanical stimulus;GO:0009636|response to toxic substance;GO:0010360|negative regulation of anion channel activity;GO:0010595|positive regulation of endothelial cell migration;GO:0010613|positive regulation of cardiac muscle hypertrophy;GO:0014070|response to organic cyclic compound;GO:0017148|negative regulation of translation;GO:0018105|peptidyl-serine phosphorylation;GO:0018107|peptidyl-threonine phosphorylation;GO:0021955|central nervous system neuron axonogenesis;GO:0030335|positive regulation of cell migration;GO:0030593|neutrophil chemotaxis;GO:0031666|positive regulation of lipopolysaccharide-mediated signaling pathway;GO:0032355|response to estradiol;GO:0034351|negative regulation of glial cell apoptotic process;GO:0035408|histone H3-T6 phosphorylation;GO:0035556|intracellular signal transduction;GO:0036289|peptidyl-serine autophosphorylation;GO:0043409|negative regulation of MAPK cascade;GO:0043434|response to peptide hormone;GO:0043536|positive regulation of blood vessel endothelial cell migration;GO:0045184|establishment of protein localization;GO:0045471|response to ethanol;GO:0045651|positive regulation of macrophage differentiation;GO:0045766|positive regulation of angiogenesis;GO:0045780|positive regulation of bone resorption;GO:0045785|positive regulation of cell adhesion;GO:0045822|negative regulation of heart contraction;GO:0045921|positive regulation of exocytosis;GO:0045931|positive regulation of mitotic cell cycle;GO:0046325|negative regulation of glucose import;GO:0046627|negative regulation of insulin receptor signaling pathway;GO:0046677|response to antibiotic;GO:0046777|protein autophosphorylation;GO:0047484|regulation of response to osmotic stress;GO:0048259|regulation of receptor-mediated endocytosis;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0050729|positive regulation of inflammatory response;GO:0050730|regulation of peptidyl-tyrosine phosphorylation;GO:0050930|induction of positive chemotaxis;GO:0051412|response to corticosterone;GO:0051965|positive regulation of synapse assembly;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070555|response to interleukin-1;GO:0071322|cellular response to carbohydrate stimulus;GO:0090330|regulation of platelet aggregation;GO:0097193|intrinsic apoptotic signaling pathway;GO:0099171|presynaptic modulation of chemical synaptic transmission;GO:2000300|regulation of synaptic vesicle exocytosis;GO:2000707|positive regulation of dense core granule biogenesis;","GO:0001750|photoreceptor outer segment;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0014704|intercalated disc;GO:0016020|membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0031966|mitochondrial membrane;GO:0032991|protein-containing complex;GO:0035866|alphav-beta3 integrin-PKCalpha complex;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0044305|calyx of Held;GO:0045121|membrane raft;GO:0045177|apical part of cell;GO:0048471|perinuclear region of cytoplasm;GO:0099523|presynaptic cytosol;","GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0004697|protein kinase C activity;GO:0004698|calcium-dependent protein kinase C activity;GO:0005178|integrin binding;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0008270|zinc ion binding;GO:0019899|enzyme binding;GO:0035403|histone kinase activity (H3-T6 specific);","K02677","PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]"]
["ENSRNOG00000068511",3,0.252405806,23,1.479600078,0.17059056,-2.551390281,0.000294218,0.000249295,"down","yes","ENSRNOG00000068511","lncRNA","chr8:118208156-118222529:+","gi|449280403|gb|EMC87722.1|",256,{"v":3e-21,"d":"3.00E-21"},"hypothetical protein A306_03536, partial [Columba livia]","gi|86261741|emb|CT486004.9|",364,0,"Mouse DNA sequence from clone RP23-424K3 on chromosome 9, complete sequence",".",".",".",".",".",".",".",".","pfam10101","DUF2339","Predicted membrane protein (DUF2339). This domain, found in various hypothetical bacterial proteins, has no known function.",".",".",".",".","."]
["ENSRNOG00000053893",8,0.673082149,36,2.315895775,0.290635769,-1.782715827,0.000299556,2.53463E-4,"down","yes","Opn4","protein_coding","chr16:9920491-10005711:-","gi|20302016|ref|NP_620215.1|",2047,0,"melanopsin [Rattus norvegicus]","gi|20302015|ref|NM_138860.1|",2166,0,"Rattus norvegicus opsin 4 (Opn4), mRNA","Q8R456",793,0,"Melanopsin",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0007601|visual perception;GO:0007602|phototransduction;GO:0007634|optokinetic behavior;GO:0009584|detection of visible light;GO:0016056|rhodopsin mediated signaling pathway;GO:0018298|protein-chromophore linkage;GO:0042752|regulation of circadian rhythm;GO:0043052|thermotaxis;GO:0043153|entrainment of circadian clock by photoperiod;GO:0045938|positive regulation of circadian sleep/wake cycle, sleep;GO:0048511|rhythmic process;GO:0050960|detection of temperature stimulus involved in thermoception;GO:0071482|cellular response to light stimulus;GO:1990384|hyaloid vascular plexus regression;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0043204|perikaryon;GO:1990913|sperm head plasma membrane;","GO:0005502|11-cis retinal binding;GO:0008020|G protein-coupled photoreceptor activity;","K04255","OPN4, Rh2_7; r-opsin"]
["ENSRNOG00000001082",12,1.009623224,45,2.894869718,0.348762923,-1.519681421,0.000310104,2.61575E-4,"down","yes","Abcb9","protein_coding","chr12:32499225-32531931:+","gi|26006275|dbj|BAC41480.1|",4137,0,"mKIAA1520 protein [Mus musculus]","gi|11560033|ref|NM_022238.1|",3271,0,"Rattus norvegicus ATP binding cassette subfamily B member 9 (Abcb9), mRNA","Q9QYJ4",1564,0,"ATP-binding cassette sub-family B member 9","BMEI0323",341,{"v":2e-102,"d":"2.00E-102"},"COG1132","pfam00664","ABC_membrane","ABC transporter transmembrane region. This family represents a unit of six transmembrane helices. Many members of the ABC transporter family (pfam00005) have two such regions.","GO:0006518|peptide metabolic process;GO:0008150|biological_process;GO:0015031|protein transport;GO:0015833|peptide transport;GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0035672|oligopeptide transmembrane transport;GO:0055085|transmembrane transport;","GO:0005764|lysosome;GO:0005765|lysosomal membrane;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0030176|integral component of endoplasmic reticulum membrane;GO:0042824|MHC class I peptide loading complex;GO:0043190|ATP-binding cassette (ABC) transporter complex;GO:0043231|intracellular membrane-bounded organelle;","GO:0005524|ATP binding;GO:0015421|oligopeptide-transporting ATPase activity;GO:0015433|peptide antigen-transporting ATPase activity;GO:0015440|peptide-transporting ATPase activity;GO:0022857|transmembrane transporter activity;GO:0042288|MHC class I protein binding;GO:0042626|ATPase activity, coupled to transmembrane movement of substances;GO:0042803|protein homodimerization activity;GO:0046978|TAP1 binding;","K05656","ABCB9, TAPL; ATP-binding cassette, subfamily B (MDR/TAP), member 9"]
["ENSRNOG00000040242",6,0.504811612,31,1.994243584,0.253134379,-1.982024635,3.13732E-4,0.00026443,"down","yes","Epm2a","protein_coding","chr1:5727066-5920555:+","gi|454522491|ref|NP_001263691.1|",1591,0,"laforin [Rattus norvegicus]","gi|14335441|gb|AF347030.1|AF347030",2394,0,"Rattus norvegicus dual-specificity phosphatase laforin (Epm2a) mRNA, partial cds","Q91XQ2",617,0,"Laforin",".",".",".",".","pfam00782","DSPc","Dual specificity phosphatase, catalytic domain. Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a \"recognition\" region.","GO:0000045|autophagosome assembly;GO:0001558|regulation of cell growth;GO:0001932|regulation of protein phosphorylation;GO:0005977|glycogen metabolic process;GO:0005978|glycogen biosynthetic process;GO:0006470|protein dephosphorylation;GO:0006816|calcium ion transport;GO:0006914|autophagy;GO:0007005|mitochondrion organization;GO:0007399|nervous system development;GO:0010468|regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010923|negative regulation of phosphatase activity;GO:0014009|glial cell proliferation;GO:0015813|L-glutamate transmembrane transport;GO:0016055|Wnt signaling pathway;GO:0016239|positive regulation of macroautophagy;GO:0016311|dephosphorylation;GO:0031396|regulation of protein ubiquitination;GO:0032007|negative regulation of TOR signaling;GO:0033137|negative regulation of peptidyl-serine phosphorylation;GO:0035305|negative regulation of dephosphorylation;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0042306|regulation of protein import into nucleus;GO:0042325|regulation of phosphorylation;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0044260|cellular macromolecule metabolic process;GO:0045786|negative regulation of cell cycle;GO:0045859|regulation of protein kinase activity;GO:0046835|carbohydrate phosphorylation;GO:0046838|phosphorylated carbohydrate dephosphorylation;GO:0046959|habituation;GO:0061136|regulation of proteasomal protein catabolic process;GO:1903076|regulation of protein localization to plasma membrane;GO:1904666|regulation of ubiquitin protein ligase activity;GO:2000465|regulation of glycogen (starch) synthase activity;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005844|polysome;GO:0005886|plasma membrane;GO:0030425|dendrite;GO:0043204|perikaryon;GO:0098554|cytoplasmic side of endoplasmic reticulum membrane;GO:0098556|cytoplasmic side of rough endoplasmic reticulum membrane;","GO:0004373|glycogen (starch) synthase activity;GO:0004721|phosphoprotein phosphatase activity;GO:0004722|protein serine/threonine phosphatase activity;GO:0004725|protein tyrosine phosphatase activity;GO:0008138|protein tyrosine/serine/threonine phosphatase activity;GO:0016791|phosphatase activity;GO:0019203|carbohydrate phosphatase activity;GO:0030246|carbohydrate binding;GO:0030247|polysaccharide binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0046983|protein dimerization activity;GO:2001069|glycogen binding;GO:2001070|starch binding;","K14165","K14165; atypical dual specificity phosphatase [EC:3.1.3.16 3.1.3.48]"]
["ENSRNOG00000063602",14,1.177893761,49,3.152191471,0.37367456,-1.420145747,0.000345864,0.000289674,"down","yes","ENSRNOG00000063602","lncRNA","chr1:181056899-181057988:-",".",".",".",".","gi|672038585|ref|XM_006230354.2|",1088,0,"PREDICTED: Rattus norvegicus SH2B adaptor protein 1 (Sh2b1), transcript variant X4, mRNA",".",".",".",".",".",".",".",".","pfam07755","DUF1611","Protein of unknown function (DUF1611). This region is found in a number of hypothetical bacterial and archaeal proteins. The region is approximately 350 residues long. A member of this family is thought to associate with another subunit to form an H+-transporting ATPase, but no evidence has been found to support this.",".",".",".",".","."]
["ENSRNOG00000065205",24,2.019246448,69,4.438800235,0.45490816,-1.136352781,0.000358433,0.000299536,"down","yes","ENSRNOG00000065205","protein_coding","chr17:2269120-2293452:+","gi|672029635|ref|XP_008771838.1|",2416,0,"PREDICTED: zinc finger protein 431-like [Rattus norvegicus]","gi|672080954|ref|XM_008771457.1|",1492,0,"PREDICTED: Rattus norvegicus zinc finger protein 845-like (LOC102556047), transcript variant X3, mRNA","E9QAG8",583,0,"Zinc finger protein 431","SPAC144.09c",111,{"v":1e-24,"d":"1.00E-24"},"COG5048","pfam02994","Transposase_22","L1 transposable element.",".",".",".",".","."]
["ENSRNOG00000004843",32,2.692328597,84,5.403756808,0.498232747,-1.005108248,3.66468E-4,0.000305709,"down","yes","Pole3","protein_coding","chr7:109236321-109236758:-","gi|532017852|ref|XP_005352678.1|",495,{"v":4e-61,"d":"4.00E-61"},"PREDICTED: DNA polymerase epsilon subunit 3 [Microtus ochrogaster]","gi|672022077|ref|XM_002726945.4|",438,0,"PREDICTED: Rattus norvegicus DNA-directed DNA polymerase epsilon 3 (LOC100362333), mRNA","Q5R4W3",195,{"v":2e-62,"d":"2.00E-62"},"DNA polymerase epsilon subunit 3",".",".",".",".","pfam00808","CBFD_NFYB_HMF","Histone-like transcription factor (CBF/NF-Y) and archaeal histone. This family includes archaebacterial histones and histone like transcription factors from eukaryotes.","GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0008622|epsilon DNA polymerase complex;","GO:0003674|molecular_function;GO:0046982|protein heterodimerization activity;","K02326","POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]"]
["ENSRNOG00000069541",16,1.346164298,53,3.409513224,0.39482595,-1.34071128,0.000368033,0.000306732,"down","yes","ENSRNOG00000069541","lncRNA","chr5:123530978-123534173:+",".",".",".",".","gi|21621601|emb|AL607070.19|",222,{"v":1e-110,"d":"1.00E-110"},"Mouse DNA sequence from clone RP23-31C9 on chromosome 4, complete sequence",".",".",".",".",".",".",".",".","pfam02665","Nitrate_red_gam","Nitrate reductase gamma subunit. This family is the gamma subunit of the nitrate reductase enzyme, the gamma subunit is a b-type cytochrome that receives electrons from the quinone pool.  It then transfers these via the iron-sulfur clusters of the beta subunit to the molybdenum cofactor found in the alpha subunit. The nitrate reductase enzyme, EC:1.7.99.4 catalyses the conversion of nitrite to nitrate via the reduction of an acceptor. The nitrate reductase enzyme is composed of three subunits. Nitrate is the most widely used alternative electron acceptor after oxygen.",".",".",".",".","."]
["ENSRNOG00000008047",1,0.084135269,16,1.029287011,0.08174131,-3.612790825,0.000374543,0.000311872,"down","yes","Khk","protein_coding","chr6:25445300-25455717:-","gi|13994119|ref|NP_114061.1|",1431,0,"ketohexokinase [Rattus norvegicus]","gi|126432547|ref|NM_031855.3|",993,0,"Rattus norvegicus ketohexokinase (Khk), mRNA","Q02974",555,0,"Ketohexokinase","APE0012",70.5,{"v":2E-12,"d":"2.00E-12"},"COG0524","pfam00294","PfkB","pfkB family carbohydrate kinase. This family includes a variety of carbohydrate and pyrimidine kinases.","GO:0006000|fructose metabolic process;GO:0009744|response to sucrose;GO:0009749|response to glucose;GO:0009750|response to fructose;GO:0010043|response to zinc ion;GO:0016052|carbohydrate catabolic process;GO:0032868|response to insulin;GO:0046835|carbohydrate phosphorylation;GO:0070873|regulation of glycogen metabolic process;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0004454|ketohexokinase activity;GO:0005524|ATP binding;","K00846","KHK; ketohexokinase [EC:2.7.1.3]"]
["ENSRNOG00000037085",1,0.084135269,16,1.029287011,0.08174131,-3.612790825,0.000374543,0.000311872,"down","yes","Xirp1","protein_coding","chr8:119747419-119757349:-","gi|564310843|ref|XP_006226682.1|",9052,0,"PREDICTED: xin actin-binding repeat-containing protein 1 isoform X1 [Rattus norvegicus]","gi|672023451|ref|XM_008757884.1|",6096,0,"PREDICTED: Rattus norvegicus xin actin-binding repeat-containing protein 1-like (LOC100910104), transcript variant X2, mRNA","Q702N8",2169,0,"Xin actin-binding repeat-containing protein 1",".",".",".",".","pfam08043","Xin","Xin repeat. The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilizing F-actin has been found in the human protein XIRP1. The homologues in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.","GO:0007015|actin filament organization;GO:0007219|Notch signaling pathway;GO:0008285|negative regulation of cell proliferation;GO:0032091|negative regulation of protein binding;GO:0042391|regulation of membrane potential;GO:0045214|sarcomere organization;GO:0055013|cardiac muscle cell development;","GO:0001725|stress fiber;GO:0005912|adherens junction;GO:0005916|fascia adherens;GO:0005925|focal adhesion;GO:0014704|intercalated disc;","GO:0051015|actin filament binding;",".","."]
["ENSRNOG00000048919",1,0.084135269,16,1.029287011,0.08174131,-3.612790825,0.000374543,0.000311872,"down","yes","Iho1","protein_coding","chr8:109092758-109125434:-","gi|392342107|ref|XP_003754504.1|",2700,0,"PREDICTED: coiled-coil domain-containing protein 36 [Rattus norvegicus]","gi|672023330|ref|XM_003754456.3|",1804,0,"PREDICTED: Rattus norvegicus coiled-coil domain containing 36 (Ccdc36), mRNA","Q6PDM4",798,0,"Interactor of HORMAD1 protein 1",".",".",".",".","pfam15479","DUF4639","Domain of unknown function (DUF4639). This family of proteins is found in eukaryotes. Proteins in this family are typically between 161 and 601 amino acids in length.","GO:0006310|DNA recombination;GO:0007129|synapsis;GO:0007283|spermatogenesis;GO:0042138|meiotic DNA double-strand break formation;GO:0048477|oogenesis;GO:0060629|regulation of homologous chromosome segregation;","GO:0000794|condensed nuclear chromosome;",".",".","."]
["ENSRNOG00000063262",1,0.084135269,16,1.029287011,0.08174131,-3.612790825,0.000374543,0.000311872,"down","yes","Ism1","protein_coding","chr3:127021865-127101894:+","gi|197387491|ref|NP_001128024.1|",2333,0,"isthmin-1 precursor [Rattus norvegicus]","gi|913512103|ref|XM_005365532.2|",2014,0,"PREDICTED: Microtus ochrogaster isthmin 1, angiogenesis inhibitor (Ism1), mRNA","A2ATD1",876,0,"Isthmin-1",".",".",".",".","pfam03782","AMOP","AMOP domain. This domain may have a role in cell adhesion. It is called the AMOP domain after Adhesion associated domain in MUC4 and Other Proteins. This domain is extracellular and contains a number of cysteines that probably form disulphide bridges.",".",".",".",".","."]
["ENSRNOG00000068158",5,0.420676343,28,1.801252269,0.2335466,-2.098217652,0.000380303,0.000316329,"down","yes","ENSRNOG00000068158","lncRNA","chr11:70709097-70740454:+",".",".",".",".","gi|354792375|gb|JN956876.1|",236,{"v":4e-118,"d":"4.00E-118"},"Mus musculus targeted deletion, lacZ-tagged mutant allele Hes1:tm1(KOMP)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam06087","Tyr-DNA_phospho","Tyrosyl-DNA phosphodiesterase. Covalent intermediates between topoisomerase I and DNA can become dead-end complexes that lead to cell death. Tyrosyl-DNA phosphodiesterase can hydrolyse the bond between topoisomerase I and DNA.",".",".",".",".","."]
["ENSRNOG00000019358",10,0.841352686,40,2.573217527,0.32696524,-1.612790825,0.00038374,0.00031909,"down","yes","Esr1","protein_coding","chr1:41210475-41495002:+","gi|661903658|gb|AIE17716.1|",2862,0,"estrogen receptor alpha c-terminus splice variant 1-2 [Rattus norvegicus]","gi|661903657|gb|KJ746833.1|",1890,0,"Rattus norvegicus estrogen receptor alpha c-terminus splice variant 1-2 (ESR1) mRNA, complete cds, alternatively spliced","P06211",1026,0,"Estrogen receptor",".",".",".",".","pfam00105","zf-C4","Zinc finger, C4 type (two domains). In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001547|antral ovarian follicle growth;GO:0002064|epithelial cell development;GO:0002076|osteoblast development;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0008209|androgen metabolic process;GO:0008584|male gonad development;GO:0010629|negative regulation of gene expression;GO:0010863|positive regulation of phospholipase C activity;GO:0030518|intracellular steroid hormone receptor signaling pathway;GO:0030520|intracellular estrogen receptor signaling pathway;GO:0032355|response to estradiol;GO:0034121|regulation of toll-like receptor signaling pathway;GO:0042981|regulation of apoptotic process;GO:0043124|negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043401|steroid hormone mediated signaling pathway;GO:0043433|negative regulation of DNA-binding transcription factor activity;GO:0043523|regulation of neuron apoptotic process;GO:0043627|response to estrogen;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0045742|positive regulation of epidermal growth factor receptor signaling pathway;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045899|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046325|negative regulation of glucose import;GO:0046697|decidualization;GO:0048146|positive regulation of fibroblast proliferation;GO:0048662|negative regulation of smooth muscle cell proliferation;GO:0048863|stem cell differentiation;GO:0050679|positive regulation of epithelial cell proliferation;GO:0050727|regulation of inflammatory response;GO:0051000|positive regulation of nitric-oxide synthase activity;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0060009|Sertoli cell development;GO:0060011|Sertoli cell proliferation;GO:0060065|uterus development;GO:0060068|vagina development;GO:0060523|prostate epithelial cord elongation;GO:0060527|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis;GO:0060687|regulation of branching involved in prostate gland morphogenesis;GO:0060745|mammary gland branching involved in pregnancy;GO:0060749|mammary gland alveolus development;GO:0060750|epithelial cell proliferation involved in mammary gland duct elongation;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071168|protein localization to chromatin;GO:0071391|cellular response to estrogen stimulus;GO:0071392|cellular response to estradiol stimulus;GO:0090209|negative regulation of triglyceride metabolic process;GO:1901215|negative regulation of neuron death;GO:1903799|negative regulation of production of miRNAs involved in gene silencing by miRNA;GO:1990375|baculum development;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0030315|T-tubule;GO:0032991|protein-containing complex;GO:0035327|transcriptionally active chromatin;GO:0043005|neuron projection;GO:0043195|terminal bouton;GO:0043204|perikaryon;GO:0048471|perinuclear region of cytoplasm;GO:0097550|transcriptional preinitiation complex;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001093|TFIIB-class transcription factor binding;GO:0001222|transcription corepressor binding;GO:0001223|transcription coactivator binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003700|DNA-binding transcription factor activity;GO:0003707|steroid hormone receptor activity;GO:0004879|nuclear receptor activity;GO:0005496|steroid binding;GO:0005515|protein binding;GO:0008013|beta-catenin binding;GO:0008270|zinc ion binding;GO:0017025|TBP-class protein binding;GO:0019899|enzyme binding;GO:0019901|protein kinase binding;GO:0030284|estrogen receptor activity;GO:0030331|estrogen receptor binding;GO:0031798|type 1 metabotropic glutamate receptor binding;GO:0034056|estrogen response element binding;GO:0036312|phosphatidylinositol 3-kinase regulatory subunit binding;GO:0042562|hormone binding;GO:0042802|identical protein binding;GO:0043565|sequence-specific DNA binding;GO:0044877|protein-containing complex binding;GO:0046872|metal ion binding;GO:0051117|ATPase binding;GO:1990837|sequence-specific double-stranded DNA binding;GO:1990841|promoter-specific chromatin binding;","K08550","ESR1, NR3A1; estrogen receptor alpha"]
["ENSRNOG00000069710",10,0.841352686,40,2.573217527,0.32696524,-1.612790825,0.00038374,0.00031909,"down","yes","Nat8f2","protein_coding","chr4:118319988-118324395:-","gi|291045290|ref|NP_001166920.1|",1195,{"v":5e-157,"d":"5.00E-157"},"probable N-acetyltransferase CML2 [Rattus norvegicus]","gi|672050328|ref|XM_006236801.2|",2010,0,"PREDICTED: Rattus norvegicus probable N-acetyltransferase CML2-like (LOC100910829), transcript variant X3, mRNA","P85118",462,{"v":1e-157,"d":"1.00E-157"},"N-acetyltransferase family 8 member 2",".",".",".",".","pfam00583","Acetyltransf_1","Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.",".",".",".",".","."]
["ENSRNOG00000018870",7,0.588946881,33,2.12290446,0.277425052,-1.849830023,0.000384435,0.000319571,"down","yes","Hapln2","protein_coding","chr2:173491160-173496588:-","gi|564337391|ref|XP_006232813.1|",1708,0,"PREDICTED: hyaluronan and proteoglycan link protein 2 isoform X1 [Rattus norvegicus]","gi|672043127|ref|XM_008761208.1|",1382,0,"PREDICTED: Rattus norvegicus hyaluronan and proteoglycan link protein 2 (Hapln2), transcript variant X1, mRNA","Q9ESM2",660,0,"Hyaluronan and proteoglycan link protein 2",".",".",".",".","pfam00193","Xlink","Extracellular link domain.","GO:0001501|skeletal system development;GO:0007155|cell adhesion;GO:0007417|central nervous system development;GO:0008065|establishment of blood-nerve barrier;GO:0085029|extracellular matrix assembly;","GO:0005576|extracellular region;GO:0031012|extracellular matrix;","GO:0005540|hyaluronic acid binding;","K06851","HAPLN2; hyaluronan and proteoglycan link protein 2"]
["ENSRNOG00000066172",7,0.588946881,33,2.12290446,0.277425052,-1.849830023,0.000384435,0.000319571,"down","yes","ENSRNOG00000066172","pseudogene","chr4:125334071-125357800:+","gi|26335481|dbj|BAC31441.1|",380,{"v":6e-44,"d":"6.00E-44"},"unnamed protein product [Mus musculus]","gi|755518147|ref|XR_035139.5|",181,{"v":3e-88,"d":"3.00E-88"},"PREDICTED: Mus musculus RIKEN cDNA A730049H05 gene (A730049H05Rik), transcript variant X2, misc_RNA",".",".",".",".",".",".",".",".","pfam00090","TSP_1","Thrombospondin type 1 domain.",".",".",".",".","."]
["ENSRNOG00000007765",30,2.524058059,80,5.146435055,0.49044786,-1.027828325,0.000397283,0.000329547,"down","yes","Frzb","protein_coding","chr3:65332277-65365208:-","gi|197313632|ref|NP_001093997.1|",1631,0,"secreted frizzled-related protein 3 precursor [Rattus norvegicus]","gi|197313631|ref|NM_001100527.1|",2737,0,"Rattus norvegicus frizzled-related protein (Frzb), mRNA","P97401",620,0,"Secreted frizzled-related protein 3",".",".",".",".","pfam01392","Fz","Fz domain. Also known as the CRD (cysteine rich domain), the C6 box in MuSK receptor. This domain of unknown function has been independently identified by several groups. The domain contains 10 conserved cysteines.","GO:0008150|biological_process;GO:0008285|negative regulation of cell proliferation;GO:0010721|negative regulation of cell development;GO:0014033|neural crest cell differentiation;GO:0030178|negative regulation of Wnt signaling pathway;GO:0030308|negative regulation of cell growth;GO:0035567|non-canonical Wnt signaling pathway;GO:0042472|inner ear morphogenesis;GO:0043065|positive regulation of apoptotic process;GO:0045600|positive regulation of fat cell differentiation;GO:0060029|convergent extension involved in organogenesis;GO:0060070|canonical Wnt signaling pathway;GO:0061037|negative regulation of cartilage development;GO:0061053|somite development;GO:0070367|negative regulation of hepatocyte differentiation;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0090103|cochlea morphogenesis;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005737|cytoplasm;","GO:0003674|molecular_function;GO:0017147|Wnt-protein binding;","K25481","FRZB, SFRP3; secreted frizzled-related protein 3"]
["ENSRNOG00000004391",0,0.042067634,14,0.900626135,0.04670932,-4.420145747,0.000400525,0.000331933,"down","yes","AABR07057436.1","protein_coding","chr7:63675579-63689392:-","gi|58585242|ref|NP_598227.3|",1641,0,"retinol dehydrogenase 7 precursor [Rattus norvegicus]","gi|841196|gb|U18762.1|RNU18762",1492,0,"Rattus norvegicus liver microsomal retinol dehydrogenase type I mRNA, complete cds","P55006",636,0,"Retinol dehydrogenase 7",".",".",".",".","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.",".",".",".",".","."]
["ENSRNOG00000049579",0,0.042067634,14,0.900626135,0.04670932,-4.420145747,0.000400525,0.000331933,"down","yes","ENSRNOG00000049579","protein_coding","chrX:139965509-140255887:+","gi|71043648|ref|NP_001019479.1|",299,{"v":6e-33,"d":"6.00E-33"},"uncharacterized protein LOC499742 [Rattus norvegicus]","gi|672032856|ref|XM_006227586.2|",557,0,"PREDICTED: Rattus norvegicus pre-mRNA-splicing factor CWC22 homolog (LOC102549073), mRNA",".",".",".",".",".",".",".",".","pfam01275","Myelin_PLP","Myelin proteolipid protein (PLP or lipophilin).",".",".",".",".","."]
["ENSRNOG00000066805",0,0.042067634,14,0.900626135,0.04670932,-4.420145747,0.000400525,0.000331933,"down","yes","ENSRNOG00000066805","lncRNA","chrX:16297627-16300926:-","gi|148675219|gb|EDL07166.1|",171,{"v":4e-12,"d":"4.00E-12"},"mCG1028420, partial [Mus musculus]","gi|73760428|gb|AC159503.10|",169,{"v":4e-81,"d":"4.00E-81"},"Mus musculus 10 BAC RP24-293I2 (Roswell Park Cancer Institute (C57BL/6J Male) Mouse BAC Library) complete sequence",".",".",".",".",".",".",".",".","pfam09771","Tmemb_18A","Transmembrane protein 188. The function of this family of transmembrane proteins has not, as yet, been determined.",".",".",".",".","."]
["ENSRNOG00000070513",0,0.042067634,14,0.900626135,0.04670932,-4.420145747,0.000400525,0.000331933,"down","yes","ENSRNOG00000070513","protein_coding","chr17:41525999-41526621:-","gi|953881761|ref|XP_014590042.1|",406,{"v":5e-46,"d":"5.00E-46"},"PREDICTED: histone H4 [Equus caballus]","gi|672030048|ref|XM_008773972.1|",414,0,"PREDICTED: Rattus norvegicus histone H4-like (LOC102551184), mRNA","Q28DR4",150,{"v":8e-45,"d":"8.00E-45"},"Histone H4",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.",".",".",".",".","."]
["ENSRNOG00000024420",29,2.439922791,78,5.017774178,0.486255998,-1.040212049,0.00041262,0.000341281,"down","yes","Eme1","protein_coding","chr10:79586729-79595435:-","gi|164663911|ref|NP_001099300.2|",2516,0,"crossover junction endonuclease EME1 [Rattus norvegicus]","gi|672068455|ref|XM_006247179.2|",1603,0,"PREDICTED: Rattus norvegicus essential meiotic structure-specific endonuclease 1 (Eme1), transcript variant X1, mRNA","Q8BJW7",793,0,"Crossover junction endonuclease EME1",".",".",".",".","pfam15265","FAM196","FAM196 family. This protein family is a domain of unknown function. This family of proteins is found in eukaryotes and are typically between 441 and 534 amino acids in length.","GO:0000712|resolution of meiotic recombination intermediates;GO:0006302|double-strand break repair;GO:0031297|replication fork processing;GO:0031573|intra-S DNA damage checkpoint;GO:0072429|response to intra-S DNA damage checkpoint signaling;GO:0090305|nucleic acid phosphodiester bond hydrolysis;","GO:0000785|chromatin;GO:0000792|heterochromatin;GO:0005634|nucleus;GO:0048476|Holliday junction resolvase complex;","GO:0003677|DNA binding;GO:0004519|endonuclease activity;","K10882","EME1, MMS4; crossover junction endonuclease EME1 [EC:3.1.22.-]"]
["ENSRNOG00000004229",11,0.925487955,42,2.701878404,0.342535013,-1.545676629,0.000418573,0.000345785,"down","yes","Tac3","protein_coding","chr7:63562552-63569170:+","gi|9507175|ref|NP_062035.1|",457,{"v":3e-54,"d":"3.00E-54"},"tachykinin-3 precursor [Rattus norvegicus]","gi|451958175|ref|NM_019162.2|",717,0,"Rattus norvegicus tachykinin 3 (Tac3), mRNA","P08435",180,{"v":1e-55,"d":"1.00E-55"},"Tachykinin-3",".",".",".",".","pfam03823","Neurokinin_B","Neurokinin B.","GO:0007217|tachykinin receptor signaling pathway;GO:0007218|neuropeptide signaling pathway;GO:0043278|response to morphine;GO:0045777|positive regulation of blood pressure;GO:1902093|positive regulation of flagellated sperm motility;","GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0031836|neuromedin K receptor binding;GO:0031837|substance K receptor binding;","K05240","TAC3; tachykinin 3"]
["ENSRNOG00000004483",4,0.336541075,25,1.608260955,0.209257754,-2.256647015,4.42464E-4,0.00036425,"down","yes","Ptprr","protein_coding","chr7:51662595-51929603:+","gi|164607158|ref|NP_446046.2|",3446,0,"receptor-type tyrosine-protein phosphatase R isoform 1 precursor [Rattus norvegicus]","gi|164607157|ref|NM_053594.2|",3561,0,"Rattus norvegicus protein tyrosine phosphatase, receptor type, R (Ptprr), transcript variant 1, mRNA","O08617",1325,0,"Receptor-type tyrosine-protein phosphatase R","SPAC11E3.09",122,{"v":8e-29,"d":"8.00E-29"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0001701|in utero embryonic development;GO:0006470|protein dephosphorylation;GO:0007399|nervous system development;GO:0010633|negative regulation of epithelial cell migration;GO:0030182|neuron differentiation;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0038128|ERBB2 signaling pathway;GO:0070373|negative regulation of ERK1 and ERK2 cascade;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030054|cell junction;","GO:0004725|protein tyrosine phosphatase activity;GO:0005515|protein binding;GO:0019901|protein kinase binding;","K04458","PTPRR; receptor-type tyrosine-protein phosphatase R [EC:3.1.3.48]"]
["ENSRNOG00000006957",4,0.336541075,25,1.608260955,0.209257754,-2.256647015,4.42464E-4,0.00036425,"down","yes","Gria4","protein_coding","chr8:1562119-2034979:-","gi|940757567|ref|XP_006098893.2|",4726,0,"PREDICTED: glutamate receptor 4 isoform X1 [Myotis lucifugus]","gi|164419760|ref|NM_017263.2|",4124,0,"Rattus norvegicus glutamate ionotropic receptor AMPA type subunit 4 (Gria4), transcript variant 1, mRNA","Q9Z2W8",1813,0,"Glutamate receptor 4","YPO1846",54.3,7e-07,"COG0834","pfam00060","Lig_chan","Ligand-gated ion channel. This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.","GO:0007268|chemical synaptic transmission;GO:0034220|ion transmembrane transport;GO:0035235|ionotropic glutamate receptor signaling pathway;GO:0050803|regulation of synapse structure or activity;GO:0050804|modulation of chemical synaptic transmission;GO:0051968|positive regulation of synaptic transmission, glutamatergic;GO:0060078|regulation of postsynaptic membrane potential;GO:0060992|response to fungicide;","GO:0005886|plasma membrane;GO:0008328|ionotropic glutamate receptor complex;GO:0014069|postsynaptic density;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0032281|AMPA glutamate receptor complex;GO:0032983|kainate selective glutamate receptor complex;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0043197|dendritic spine;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0098978|glutamatergic synapse;GO:0099061|integral component of postsynaptic density membrane;","GO:0004970|ionotropic glutamate receptor activity;GO:0004971|AMPA glutamate receptor activity;GO:0005515|protein binding;GO:0015276|ligand-gated ion channel activity;GO:0038023|signaling receptor activity;GO:0042802|identical protein binding;GO:1904315|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K05200","GRIA4; glutamate receptor 4"]
["ENSRNOG00000062702",4,0.336541075,25,1.608260955,0.209257754,-2.256647015,4.42464E-4,0.00036425,"down","yes","ENSRNOG00000062702","lncRNA","chr20:12420808-12423028:+",".",".",".",".","gi|672031625|ref|XR_599383.1|",520,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103694402 (LOC103694402), ncRNA",".",".",".",".",".",".",".",".","pfam01500","Keratin_B2","Keratin, high sulfur B2 protein. High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.",".",".",".",".","."]
["ENSRNOG00000000588",12,1.009623224,44,2.83053928,0.356689353,-1.487259943,0.000448127,0.000368689,"down","yes","Slc16a10","protein_coding","chr20:43459709-43567839:-","gi|672086586|ref|XP_008771196.1|",2346,0,"PREDICTED: monocarboxylate transporter 10 isoform X1 [Rattus norvegicus]","gi|672086585|ref|XM_008772974.1|",2481,0,"PREDICTED: Rattus norvegicus solute carrier family 16 (aromatic amino acid transporter), member 10 (Slc16a10), transcript variant X1, mRNA","Q91Y77",904,0,"Monocarboxylate transporter 10","AF0367",50.8,1e-05,"COG0477","pfam07690","MFS_1","Major Facilitator Superfamily.","GO:0006590|thyroid hormone generation;GO:0015801|aromatic amino acid transport;GO:0055085|transmembrane transport;GO:0070327|thyroid hormone transport;GO:0070460|thyroid-stimulating hormone secretion;","GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0030054|cell junction;GO:0043231|intracellular membrane-bounded organelle;","GO:0015173|aromatic amino acid transmembrane transporter activity;GO:0015349|thyroid hormone transmembrane transporter activity;","K08187","SLC16A10; MFS transporter, MCT family, solute carrier family 16 (monocarboxylic acid transporters), member 10"]
["ENSRNOG00000065376",26,2.187516985,72,4.631791549,0.472283124,-1.082276109,0.000456786,0.000375246,"down","yes","ENSRNOG00000065376","lncRNA","chr3:156392971-156394687:-",".",".",".",".","gi|31616713|emb|AL935060.17|",197,{"v":2e-96,"d":"2.00E-96"},"Mouse DNA sequence from clone RP24-151H6 on chromosome 2, complete sequence",".",".",".",".",".",".",".",".","pfam02948","Amelogenin","Amelogenin. Amelogenins play a role in biomineralisation. They seem to regulate the formation of crystallites during the secretory stage of tooth enamel development. thought to play a major role in the structural organisation and mineralisation of developing enamel. They are found in the extracellular matrix. Mutations in X-chromosomal amelogenin can cause Amelogenesis imperfecta.",".",".",".",".","."]
["ENSRNOG00000062821",2,0.168270537,19,1.222278326,0.137669575,-2.860718339,0.00047073,0.000385885,"down","yes","ENSRNOG00000062821","protein_coding","chr16:16018228-16019934:+","gi|564339731|ref|XP_006233747.1|",1138,{"v":5e-154,"d":"5.00E-154"},"PREDICTED: serologically defined colon cancer antigen 3 isoform X5 [Rattus norvegicus]","gi|564388348|ref|XM_006252792.1|",636,0,"PREDICTED: Rattus norvegicus serologically defined colon cancer antigen 3 (LOC100363321), mRNA","A2AIW0",344,{"v":1e-115,"d":"1.00E-115"},"Serologically defined colon cancer antigen 3 homolog",".",".",".",".","pfam07394","DUF1501","Protein of unknown function (DUF1501). This family contains a number of hypothetical bacterial proteins of unknown function approximately 400 residues long.",".",".",".",".","."]
["ENSRNOG00000023312",13,1.093758492,46,2.959200157,0.36961288,-1.435913063,0.000472398,0.000387078,"down","yes","Lonrf2","protein_coding","chr9:41034628-41070649:-","gi|564311487|ref|XP_006226872.1|",3745,0,"PREDICTED: LON peptidase N-terminal domain and RING finger protein 2 [Rattus norvegicus]","gi|672023942|ref|XM_006226810.2|",3480,0,"PREDICTED: Rattus norvegicus LON peptidase N-terminal domain and ring finger 2 (Lonrf2), mRNA","Q1L5Z9",1067,0,"LON peptidase N-terminal domain and RING finger protein 2","sll0195",72.4,{"v":6e-13,"d":"6.00E-13"},"COG2802","pfam02190","LON","ATP-dependent protease La (LON) domain. This domain has been shown to be part of the PUA superfamily.",".",".","GO:0046872|metal ion binding;",".","."]
["ENSRNOG00000000138",6,0.504811612,30,1.929913146,0.261572192,-1.93471892,4.84902E-4,0.000396548,"down","yes","Glis1","protein_coding","chr5:122222128-122412141:+","gi|564305844|ref|XP_006225510.1|",3160,0,"PREDICTED: zinc finger protein GLIS1 [Rattus norvegicus]","gi|672019711|ref|XM_006225448.2|",2816,0,"PREDICTED: Rattus norvegicus GLIS family zinc finger 1 (Glis1), mRNA","Q8K1M4",1153,0,"Zinc finger protein GLIS1",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001649|osteoblast differentiation;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008150|biological_process;GO:0010454|negative regulation of cell fate commitment;GO:0045444|fat cell differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005575|cellular_component;GO:0005634|nucleus;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0046872|metal ion binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09232","GLIS1_3; zinc finger protein GLIS1/3"]
["ENSRNOG00000037229",6,0.504811612,30,1.929913146,0.261572192,-1.93471892,4.84902E-4,0.000396548,"down","yes","Gmppb","protein_coding","chr8:108693060-108767286:+","gi|564365550|ref|XP_006243873.1|",1888,0,"PREDICTED: mannose-1-phosphate guanyltransferase beta isoform X1 [Rattus norvegicus]","gi|564365605|ref|XM_006243839.1|",3258,0,"PREDICTED: Rattus norvegicus inositol hexakisphosphate kinase 1 (Ip6k1), transcript variant X1, mRNA","Q9ESM0",514,0,"Inositol hexakisphosphate kinase 1","SPCC1906.01",454,{"v":9E-143,"d":"9.00E-143"},"COG1208","pfam00483","NTP_transferase","Nucleotidyl transferase. This family includes a wide range of enzymes which transfer nucleotides onto phosphosugars.","GO:0000032|cell wall mannoprotein biosynthetic process;GO:0006486|protein glycosylation;GO:0009298|GDP-mannose biosynthetic process;","GO:0005737|cytoplasm;","GO:0004475|mannose-1-phosphate guanylyltransferase activity;GO:0016779|nucleotidyltransferase activity;","K00966","GMPP; mannose-1-phosphate guanylyltransferase [EC:2.7.7.13]"]
["ENSRNOG00000053795",21,1.766840642,62,3.988487167,0.442985164,-1.174669713,0.000512774,0.00041771,"down","yes","Gm24494","snoRNA","chr2:242849608-242849688:-",".",".",".",".","gi|908663675|tpe|LN872853.1|",69,{"v":7e-27,"d":"7.00E-27"},"TPA: Mus musculus SNORD45 gene for small nucleolar RNA SNORD45",".",".",".",".",".",".",".",".","pfam05351","GMP_PDE_delta","GMP-PDE, delta subunit. GMP-PDE delta subunit was originally identified as a fourth subunit of rod-specific cGMP phosphodiesterase (PDE)(EC:3.1.4.35). The precise function of PDE delta subunit in the rod specific GMP-PDE complex is unclear. In addition, PDE delta subunit is not confined to photoreceptor cells but is widely distributed in different tissues. PDE delta subunit is thought to be a specific soluble transport factor for certain prenylated proteins and Arl2-GTP a regulator of PDE-mediated transport.",".",".",".",".","."]
["ENSRNOG00000019474",17,1.430299567,54,3.473843662,0.411734006,-1.280215486,0.000521626,4.2454E-4,"down","yes","Rsph9","protein_coding","chr9:14840115-14860062:+","gi|564367377|ref|XP_006244600.1|",1350,0,"PREDICTED: radial spoke head protein 9 homolog isoform X1 [Rattus norvegicus]","gi|672064340|ref|XM_006244538.2|",947,0,"PREDICTED: Rattus norvegicus radial spoke head 9 homolog (Chlamydomonas) (Rsph9), transcript variant X1, mRNA","Q9D9V4",509,{"v":1E-176,"d":"1.00E-176"},"Radial spoke head protein 9 homolog",".",".",".",".","pfam04712","Radial_spoke","Radial spokehead-like protein. This family includes the radial spoke head proteins RSP4 and RSP6 from Chlamydomonas reinhardtii, and several eukaryotic homologues, including mammalian RSHL1, the protein product of a familial ciliary dyskinesia candidate gene.","GO:0003341|cilium movement;GO:0035082|axoneme assembly;GO:0044458|motile cilium assembly;GO:0060294|cilium movement involved in cell motility;GO:1904158|axonemal central apparatus assembly;","GO:0001534|radial spoke;GO:0005930|axoneme;GO:0031514|motile cilium;GO:0097729|9+2 motile cilium;",".","K19757","RSPH9; radial spoke head protein 9"]
["ENSRNOG00000065918",30,2.524058059,79,5.082104617,0.496656061,-1.009680978,0.000523525,0.000425958,"down","yes","Tceanc","protein_coding","chrX:27952457-27960940:+","gi|157824026|ref|NP_001102485.1|",1767,0,"transcription elongation factor A N-terminal and central domain-containing protein [Rattus norvegicus]","gi|672087385|ref|XM_006256856.2|",1647,0,"PREDICTED: Rattus norvegicus transcription elongation factor A (SII) N-terminal and central domain containing (Tceanc), transcript variant X1, mRNA","Q3US16",591,0,"Transcription elongation factor A N-terminal and central domain-containing protein","ECU04g0180",68.2,{"v":2e-11,"d":"2.00E-11"},"COG1594","pfam07500","TFIIS_M","Transcription factor S-II (TFIIS), central domain. Transcription elongation by RNA polymerase II is regulated by the general elongation factor TFIIS. This factor stimulates RNA polymerase II to transcribe through regions of DNA that promote the formation of stalled ternary complexes. TFIIS is composed of three structural domains, termed I, II, and III. The two C-terminal domains (II and III), this domain and pfam01096 are required for transcription activity.",".",".",".",".","."]
["ENSRNOG00000023931",18,1.514434836,56,3.602504538,0.42038388,-1.250220746,0.000523831,0.00042614,"down","yes","Ggn","protein_coding","chr1:84470508-84474114:+","gi|832626162|ref|NP_001013083.2|",1780,0,"gametogenetin isoform 1 [Rattus norvegicus]","gi|61556843|ref|NM_001013065.1|",2411,0,"Rattus norvegicus gametogenetin (Ggn), transcript variant 1, mRNA","Q66HC8",617,0,"Gametogenetin",".",".",".",".","pfam06566","Chon_Sulph_att","Chondroitin sulphate attachment domain. This family represents the chondroitin sulphate attachment domain of vertebrate neural transmembrane proteoglycans that contain EGF modules. Evidence has been accumulated to support the idea that neural proteoglycans are involved in various cellular events including mitogenesis, differentiation, axonal outgrowth and synaptogenesis. This domain contains several potential sites of chondroitin sulphate attachment, as well as potential sites of N-linked glycosylation.","GO:0006302|double-strand break repair;GO:0007276|gamete generation;GO:0007283|spermatogenesis;GO:0007566|embryo implantation;GO:0008104|protein localization;GO:0030154|cell differentiation;","GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0048471|perinuclear region of cytoplasm;","GO:0031625|ubiquitin protein ligase binding;GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000029047",10,0.841352686,39,2.508887089,0.335348964,-1.576264949,0.000563289,0.000454576,"down","yes","Cubn","protein_coding","chr17:76385060-76593231:-","gi|149021111|gb|EDL78718.1|",19160,0,"cubilin (intrinsic factor-cobalamin receptor), isoform CRA_b [Rattus norvegicus]","gi|24475743|ref|NM_053332.2|",11205,0,"Rattus norvegicus cubilin (Cubn), mRNA","O70244",7374,0,"Cubilin",".",".",".",".","pfam00431","CUB","CUB domain.","GO:0001701|in utero embryonic development;GO:0006766|vitamin metabolic process;GO:0006898|receptor-mediated endocytosis;GO:0007584|response to nutrient;GO:0008203|cholesterol metabolic process;GO:0009617|response to bacterium;GO:0015889|cobalamin transport;GO:0020028|endocytic hemoglobin import;GO:0042366|cobalamin catabolic process;GO:0042953|lipoprotein transport;","GO:0005737|cytoplasm;GO:0005765|lysosomal membrane;GO:0005768|endosome;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005798|Golgi-associated vesicle;GO:0005886|plasma membrane;GO:0005903|brush border;GO:0005905|clathrin-coated pit;GO:0010008|endosome membrane;GO:0016020|membrane;GO:0016324|apical plasma membrane;GO:0030135|coated vesicle;GO:0030139|endocytic vesicle;GO:0030666|endocytic vesicle membrane;GO:0031526|brush border membrane;GO:0032991|protein-containing complex;GO:0043202|lysosomal lumen;GO:0043235|receptor complex;GO:0045177|apical part of cell;GO:0070062|extracellular exosome;","GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0030492|hemoglobin binding;GO:0031419|cobalamin binding;GO:0038023|signaling receptor activity;GO:0038024|cargo receptor activity;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;","K14616","CUBN; cubilin"]
["ENSRNOG00000064815",10,0.841352686,39,2.508887089,0.335348964,-1.576264949,0.000563289,0.000454576,"down","yes","ENSRNOG00000064815","lncRNA","chr9:55970994-55975483:+","gi|74206346|dbj|BAE24906.1|",194,{"v":3e-14,"d":"3.00E-14"},"unnamed protein product [Mus musculus]","gi|354458917|ref|NM_001163314.2|",798,0,"Mus musculus post-GPI attachment to proteins 1 (Pgap1), mRNA",".",".",".",".",".",".",".",".","pfam06027","DUF914","Eukaryotic protein of unknown function (DUF914). This family consists of several hypothetical proteins of unknown function. Some of the sequences in this family are annotated as being putative membrane proteins.",".",".",".",".","."]
["ENSRNOG00000064125",7,0.588946881,32,2.058574022,0.286094585,-1.805435903,5.84345E-4,0.000470174,"down","yes","ENSRNOG00000064125","lncRNA","chr12:41284548-41307213:+","gi|12842035|dbj|BAB25444.1|",132,1e-06,"unnamed protein product [Mus musculus]","gi|354783725|gb|JN948226.1|",101,{"v":2e-43,"d":"2.00E-43"},"Mus musculus targeted deletion, lacZ-tagged mutant allele Dynll1:tm1(KOMP)Ucd; transgenic",".",".",".",".",".",".",".",".","pfam12885","TORC_M","Transducer of regulated CREB activity middle domain. This family includes the region between the N and C terminus of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerization domain of CREB (cAMP Response Element-Binding). Although the C- and N- terminal domains of these proteins have been well characterized, no functional role has been assigned to the central region, yet.",".",".",".",".","."]
["ENSRNOG00000065393",12,1.009623224,43,2.766208842,0.364984454,-1.454093079,0.000644772,0.000515368,"down","yes","ENSRNOG00000065393","lncRNA","chr9:14418617-14426290:-","gi|148689093|gb|EDL21040.1|",159,{"v":2e-10,"d":"2.00E-10"},"mCG140729 [Mus musculus]","gi|354792425|gb|JN956926.1|",230,{"v":4e-115,"d":"4.00E-115"},"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Srf:tm1a(EUCOMM)Hmgu; transgenic",".",".",".",".",".",".",".",".","pfam14396","CFTR_R","Cystic fibrosis TM conductance regulator (CFTR), regulator domain.",".",".",".",".","."]
["ENSRNOG00000007232",1,0.084135269,15,0.964956573,0.087190731,-3.519681421,0.000649035,0.000518091,"down","yes","Lao1","protein_coding","chr5:132573698-132583582:+","gi|157817668|ref|NP_001100152.1|",2519,0,"L-amino acid oxidase 1 precursor [Rattus norvegicus]","gi|157817667|ref|NM_001106682.1|",1887,0,"Rattus norvegicus L-amino acid oxidase 1 (Lao1), mRNA","A8QL52",464,{"v":3e-155,"d":"3.00E-155"},"L-amino-acid oxidase","BS_yobN",218,{"v":2e-62,"d":"2.00E-62"},"COG1231","pfam01593","Amino_oxidase","Flavin containing amine oxidoreductase. This family consists of various amine oxidases, including maze polyamine oxidase (PAO) and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.","GO:0009063|cellular amino acid catabolic process;","GO:0005576|extracellular region;","GO:0001716|L-amino-acid oxidase activity;GO:0016491|oxidoreductase activity;GO:0046592|polyamine oxidase activity;","K03334","IL4I1; L-amino-acid oxidase [EC:1.4.3.2]"]
["ENSRNOG00000039396",1,0.084135269,15,0.964956573,0.087190731,-3.519681421,0.000649035,0.000518091,"down","yes","Btnl3","protein_coding","chr20:4474056-4489024:-","gi|261599028|ref|NP_001002803.2|",2517,0,"butyrophilin-like protein 1 [Rattus norvegicus]","gi|261599027|ref|NM_001002803.2|",2040,0,"Rattus norvegicus butyrophilin-like 3 (Btnl3), mRNA","Q7TST0",793,0,"Butyrophilin-like protein 1",".",".",".",".","pfam00622","SPRY","SPRY domain. SPRY Domain is named from SPla and the RYanodine Receptor. Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.","GO:0001817|regulation of cytokine production;GO:0050852|T cell receptor signaling pathway;","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0005102|signaling receptor binding;","K06712","BTN, CD277; butyrophilin"]
["ENSRNOG00000064890",1,0.084135269,15,0.964956573,0.087190731,-3.519681421,0.000649035,0.000518091,"down","yes","ENSRNOG00000064890","pseudogene","chr14:46603666-46604536:-","gi|612002131|ref|XP_007485990.1|",556,{"v":2E-66,"d":"2.00E-66"},"PREDICTED: transformer-2 protein homolog beta-like isoform X1 [Monodelphis domestica]","gi|672076320|ref|XR_359545.2|",703,0,"PREDICTED: Rattus norvegicus similar to splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) (LOC685935), transcript variant X2, misc_RNA","P62997",213,{"v":4e-66,"d":"4.00E-66"},"Transformer-2 protein homolog beta",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.",".",".",".",".","."]
["ENSRNOG00000068054",1,0.084135269,15,0.964956573,0.087190731,-3.519681421,0.000649035,0.000518091,"down","yes","ENSRNOG00000068054","lncRNA","chrX:19419114-19461465:-",".",".",".",".","gi|22859064|emb|AL808140.5|",391,0,"Mouse DNA sequence from clone RP23-147K5 on chromosome X, complete sequence",".",".",".",".",".",".",".",".","pfam01728","FtsJ","FtsJ-like methyltransferase. This family consists of FtsJ from various bacterial and archaeal sources FtsJ is a methyltransferase, but actually has no effect on cell division. FtsJ's substrate is the 23S rRNA. The 1.5 A crystal structure of FtsJ in complex with its cofactor S-adenosylmethionine revealed that FtsJ has a methyltransferase fold. This family also includes the N terminus of flaviviral NS5 protein. It has been hypothesised that the N-terminal domain of NS5 is a methyltransferase involved in viral RNA capping.",".",".",".",".","."]
["ENSRNOG00000019035",23,1.935111179,65,4.181478482,0.46278157,-1.111596682,0.000666386,0.000531162,"down","yes","Trpm8","protein_coding","chr9:88903880-88988552:+","gi|52851375|ref|NP_599198.2|",5767,0,"transient receptor potential cation channel subfamily M member 8 [Rattus norvegicus]","gi|52851374|ref|NM_134371.2|",4118,0,"Rattus norvegicus transient receptor potential cation channel, subfamily M, member 8 (Trpm8), mRNA","Q8R455",2211,0,"Transient receptor potential cation channel subfamily M member 8",".",".",".",".","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0006816|calcium ion transport;GO:0006874|cellular calcium ion homeostasis;GO:0009266|response to temperature stimulus;GO:0009409|response to cold;GO:0016048|detection of temperature stimulus;GO:0019722|calcium-mediated signaling;GO:0050955|thermoception;GO:0070588|calcium ion transmembrane transport;GO:0098655|cation transmembrane transport;GO:0120162|positive regulation of cold-induced thermogenesis;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0016020|membrane;GO:0045121|membrane raft;","GO:0005216|ion channel activity;GO:0005261|cation channel activity;GO:0005262|calcium channel activity;GO:0005515|protein binding;GO:0042802|identical protein binding;GO:0099604|ligand-gated calcium channel activity;","K04983","TRPM8; transient receptor potential cation channel subfamily M member 8"]
["ENSRNOG00000009815",13,1.093758492,45,2.894869718,0.3778265,-1.404204203,0.000673847,0.000536795,"down","yes","Pnma2","protein_coding","chr15:41112009-41121427:+","gi|157822619|ref|NP_001100742.1|",1763,0,"paraneoplastic antigen Ma2 [Rattus norvegicus]","gi|157822618|ref|NM_001107272.1|",3241,0,"Rattus norvegicus paraneoplastic Ma antigen 2 (Pnma2), mRNA","Q8BHK0",639,0,"Paraneoplastic antigen Ma2 homolog",".",".",".",".","pfam14893","PNMA","PNMA. The PNMA family includes paraneoplastic antigens Ma 1, 2 and 3, found in the serum of patients with paraneoplastic neurological disorders. The family also includes modulator of apoptosis 1, which has a role in death receptor-dependent apoptosis.",".","GO:0005730|nucleolus;",".",".","."]
["ENSRNOG00000031852",13,1.093758492,45,2.894869718,0.3778265,-1.404204203,0.000673847,0.000536795,"down","yes","Lsamp","protein_coding","chr11:58554805-60717029:-","gi|30425330|ref|NP_780757.1|",1527,0,"limbic system-associated membrane protein precursor [Mus musculus]","gi|672071129|ref|XM_006248339.2|",1423,0,"PREDICTED: Rattus norvegicus limbic system-associated membrane protein (Lsamp), transcript variant X1, mRNA","Q8BLK3",592,0,"Limbic system-associated membrane protein",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0007155|cell adhesion;GO:0035641|locomotory exploration behavior;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0031225|anchored component of membrane;",".","K06772","LSAMP, LAMP; limbic system-associated membrane protein"]
["ENSRNOG00000057072",8,0.673082149,34,2.187234898,0.307731991,-1.700253667,0.000675071,0.000537692,"down","yes","Slc12a3","protein_coding","chr19:10631393-10669091:-","gi|158186720|ref|NP_062218.3|",5208,0,"solute carrier family 12 member 3 [Rattus norvegicus]","gi|158186719|ref|NM_019345.3|",3683,0,"Rattus norvegicus solute carrier family 12 (sodium/chloride transporters), member 3 (Slc12a3), mRNA","P55018",2006,0,"Solute carrier family 12 member 3","SPBC18H10.16",257,{"v":7e-70,"d":"7.00E-70"},"COG0531","pfam00324","AA_permease","Amino acid permease.","GO:0006814|sodium ion transport;GO:0006821|chloride transport;GO:0006884|cell volume homeostasis;GO:0015698|inorganic anion transport;GO:0035725|sodium ion transmembrane transport;GO:0055064|chloride ion homeostasis;GO:0055075|potassium ion homeostasis;GO:0055078|sodium ion homeostasis;GO:0070294|renal sodium ion absorption;GO:1902476|chloride transmembrane transport;GO:1990573|potassium ion import across plasma membrane;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0031982|vesicle;GO:0070062|extracellular exosome;","GO:0008511|sodium:potassium:chloride symporter activity;GO:0015081|sodium ion transmembrane transporter activity;GO:0015377|cation:chloride symporter activity;GO:0015378|sodium:chloride symporter activity;GO:0015379|potassium:chloride symporter activity;GO:0019899|enzyme binding;","K14426","SLC12A3, TSC; solute carrier family 12 (sodium/chloride transporter), member 3"]
["ENSRNOG00000005053",14,1.177893761,47,3.023530595,0.389575605,-1.360024755,0.000695671,0.000552644,"down","yes","Egln3","protein_coding","chr6:71650297-71675766:-","gi|149051230|gb|EDM03403.1|",1817,0,"rCG62399 [Rattus norvegicus]","gi|9507122|ref|NM_019371.1|",2750,0,"Rattus norvegicus egl-9 family hypoxia-inducible factor 3 (Egln3), mRNA","Q91UZ4",501,{"v":8e-170,"d":"8.00E-170"},"Egl nine homolog 3","PA0310",59.7,5e-09,"COG3751","pfam13640","2OG-FeII_Oxy_3","2OG-Fe(II) oxygenase superfamily. This family contains members of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily.","GO:0001666|response to hypoxia;GO:0006915|apoptotic process;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006974|cellular response to DNA damage stimulus;GO:0018126|protein hydroxylation;GO:0018401|peptidyl-proline hydroxylation to 4-hydroxy-L-proline;GO:0042127|regulation of cell proliferation;GO:0043523|regulation of neuron apoptotic process;GO:0071456|cellular response to hypoxia;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0005506|iron ion binding;GO:0005515|protein binding;GO:0008198|ferrous iron binding;GO:0016706|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0031418|L-ascorbic acid binding;GO:0031543|peptidyl-proline dioxygenase activity;GO:0031545|peptidyl-proline 4-dioxygenase activity;","K09592","EGLN, HPH; hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29]"]
["ENSRNOG00000014135",21,1.766840642,61,3.924156729,0.450247216,-1.15121074,6.96881E-4,0.000553283,"down","yes","Rab11fip4","protein_coding","chr10:64550177-64654759:+","gi|157823005|ref|NP_001100493.1|",2913,0,"rab11 family-interacting protein 4 [Rattus norvegicus]","gi|157823004|ref|NM_001107023.1|",3127,0,"Rattus norvegicus RAB11 family interacting protein 4 (class II) (Rab11fip4), mRNA","Q8BQP8",1088,0,"Rab11 family-interacting protein 4",".",".",".",".","pfam09457","RBD-FIP","FIP domain. The FIP domain is the Rab11-binding domain (RBD) at the C-terminus of a family of Rab11-interacting proteins (FIPs). The Rab proteins constitute the largest family of small GTPases (>60 members in mammals). Among them Rab11 is a well characterized regulator of endocytic and recycling pathways. Rab11 associates with a broad range of post-Golgi organelles, including recycling endosomes.","GO:0003407|neural retina development;GO:0032456|endocytic recycling;GO:0032465|regulation of cytokinesis;GO:1903452|positive regulation of G1 to G0 transition;","GO:0005768|endosome;GO:0005813|centrosome;GO:0030139|endocytic vesicle;GO:0030496|midbody;GO:0032154|cleavage furrow;GO:0048471|perinuclear region of cytoplasm;GO:0055038|recycling endosome membrane;","GO:0005509|calcium ion binding;GO:0031267|small GTPase binding;GO:0042803|protein homodimerization activity;","K12485","RAB11FIP3_4; Rab11 family-interacting protein 3/4"]
["ENSRNOG00000031449",21,1.766840642,61,3.924156729,0.450247216,-1.15121074,6.96881E-4,0.000553283,"down","yes","RGD1306441","protein_coding","chr15:72466016-72468703:+","gi|157823325|ref|NP_001099523.1|",1401,0,"uncharacterized protein LOC290425 [Rattus norvegicus]","gi|157823324|ref|NM_001106053.1|",1134,0,"Rattus norvegicus similar to RIKEN cDNA 4921530L21 (RGD1306441), mRNA",".",".",".",".",".",".",".",".","pfam14915","CCDC144C","CCDC144C protein coiled-coil region. This family includes the human protein CCDC144C and the ankyrin repeat domain-containing protein 26-like 1 found in eukaryotes. Its function remains unknown, however, it is known to contain a coiled-coil domain which corresponds to this region. The ankyrin repeat which features in this protein is a common amino acid motif.",".",".",".",".","."]
["ENSRNOG00000035613",21,1.766840642,61,3.924156729,0.450247216,-1.15121074,6.96881E-4,0.000553283,"down","yes","Mir7-1","miRNA","chr17:6273264-6273360:+",".",".",".",".","gi|297139680|ref|NR_031795.1|",97,{"v":2e-42,"d":"2.00E-42"},"Rattus norvegicus microRNA 7a-1 (Mir7a-1), microRNA",".",".",".",".",".",".",".",".","pfam14102","Caps_synth_CapC","Capsule biosynthesis CapC. This family of proteins play a role in capsule biosynthesis. They are essential for gamma-polyglutamic acid (PGA) production.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0003309|type B pancreatic cell differentiation;GO:0009617|response to bacterium;GO:0010608|posttranscriptional regulation of gene expression;GO:0035195|gene silencing by miRNA;GO:0060291|long-term synaptic potentiation;GO:0060395|SMAD protein signal transduction;GO:0060576|intestinal epithelial cell development;GO:0071222|cellular response to lipopolysaccharide;GO:0071241|cellular response to inorganic substance;GO:1904322|cellular response to forskolin;GO:1990830|cellular response to leukemia inhibitory factor;GO:2000227|negative regulation of pancreatic A cell differentiation;","GO:0016442|RISC complex;",".","K17365","MIR7; microRNA 7"]
["ENSRNOG00000064368",21,1.766840642,61,3.924156729,0.450247216,-1.15121074,6.96881E-4,0.000553283,"down","yes","Cebpzos","protein_coding","chr6:16133410-16140151:-","gi|149050632|gb|EDM02805.1|",418,{"v":2E-45,"d":"2.00E-45"},"rCG62056, isoform CRA_a [Rattus norvegicus]","gi|672020408|ref|XR_601333.1|",469,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103692531 (LOC103692531), transcript variant X5, ncRNA","Q8BTE5",148,{"v":2e-40,"d":"2.00E-40"},"Protein CEBPZOS",".",".",".",".","pfam09815","XK-related","XK-related protein. Members of this family comprise various XK-related proteins, that are involved in sodium-dependent transport of neutral amino acids or oligopeptides. These proteins are responsible for the Kx blood group system - defects results in McLeod syndrome, an X-linked multi-system disorder characterized by late onset abnormalities in the neuromuscular and hematopoietic systems.",".",".",".",".","."]
["ENSRNOG00000048230",0,0.042067634,13,0.836295696,0.050302345,-4.313230543,0.000697112,0.000553305,"down","yes","ENSRNOG00000048230","protein_coding","chr7:15821379-15838813:+","gi|392349284|ref|XP_234980.5|",2159,0,"PREDICTED: sperm motility kinase W-like [Rattus norvegicus]","gi|672058325|ref|XR_593312.1|",1678,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102557062 (LOC102557062), transcript variant X7, ncRNA","Q8C0V7",577,0,"Putative sperm motility kinase W",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006468|protein phosphorylation;GO:0035556|intracellular signal transduction;GO:0043066|negative regulation of apoptotic process;","GO:0005737|cytoplasm;","GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;",".","."]
["ENSRNOG00000069740",0,0.042067634,13,0.836295696,0.050302345,-4.313230543,0.000697112,0.000553305,"down","yes","ENSRNOG00000069740","lncRNA","chr5:149255275-149283843:-","gi|149024333|gb|EDL80830.1|",203,{"v":6e-17,"d":"6.00E-17"},"rCG31004 [Rattus norvegicus]","gi|672054547|ref|XM_008764267.1|",201,{"v":6e-99,"d":"6.00E-99"},"PREDICTED: Rattus norvegicus zinc finger and BTB domain containing 40 (Zbtb40), transcript variant X5, mRNA",".",".",".",".",".",".",".",".","pfam14964","DUF4507","Domain of unknown function (DUF4507). This family of proteins is found in eukaryotes. Proteins in this family are typically between 346 and 434 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000012358",4,0.336541075,24,1.543930516,0.217976827,-2.197753326,7.06783E-4,0.00056049,"down","yes","ENSRNOG00000012358","protein_coding","chrX:58378116-58468935:+","gi|564399412|ref|XP_006257079.1|",1652,0,"PREDICTED: choline-phosphate cytidylyltransferase B isoform X2 [Rattus norvegicus]","gi|27465630|ref|NM_173151.1|",1802,0,"Rattus norvegicus phosphate cytidylyltransferase 1, choline, beta (Pcyt1b), mRNA","Q9QZC4",602,0,"Choline-phosphate cytidylyltransferase B","ECU10g1590",266,{"v":1e-81,"d":"1.00E-81"},"COG0615","pfam01467","CTP_transf_2","Cytidylyltransferase. This family includes: Cholinephosphate cytidylyltransferase and Glycerol-3-phosphate cytidylyltransferase.","GO:0001541|ovarian follicle development;GO:0006656|phosphatidylcholine biosynthetic process;GO:0006657|CDP-choline pathway;GO:0007283|spermatogenesis;GO:1904116|response to vasopressin;","GO:0005783|endoplasmic reticulum;","GO:0004105|choline-phosphate cytidylyltransferase activity;GO:0031210|phosphatidylcholine binding;GO:0042802|identical protein binding;","K00968","PCYT1; choline-phosphate cytidylyltransferase [EC:2.7.7.15]"]
["ENSRNOG00000050177",15,1.26202903,49,3.152191471,0.4003656,-1.320610074,0.000710811,0.000563602,"down","yes","ENSRNOG00000050177","protein_coding","chrX:150990735-151003268:-","gi|392344403|ref|XP_003748951.1|",1247,{"v":1E-168,"d":"1.00E-168"},"PREDICTED: X-linked lymphocyte-regulated protein 3A-like isoform X4 [Rattus norvegicus]","gi|672037449|ref|XM_006229620.2|",1100,0,"PREDICTED: Rattus norvegicus synaptonemal complex protein 3-like (LOC100911002), transcript variant X7, mRNA","Q9JJR2",249,{"v":4E-79,"d":"4.00E-79"},"X-linked lymphocyte-regulated protein 5C",".",".",".",".","pfam04803","Cor1","Cor1/Xlr/Xmr conserved region. Cor1 is a component of the chromosome core in the meiotic prophase chromosomes. Xlr is a lymphoid cell specific protein. Xlm is abundantly transcribed in testis in a tissue-specific and developmentally regulated manner. The protein is located in the nuclei of spermatocytes, early in the prophase of the first meiotic division, and later becomes concentrated in the XY nuclear subregion where it is in particular associated with the axes of sex chromosomes.",".",".",".",".","."]
["ENSRNOG00000069530",18,1.514434836,55,3.5381741,0.428027223,-1.224225537,0.000722523,0.000572472,"down","yes","ENSRNOG00000069530","protein_coding","chr7:12647926-12693574:-","gi|672033285|ref|XP_006227110.2|",2848,0,"PREDICTED: zinc finger protein 709-like isoform X1 [Rattus norvegicus]","gi|672033284|ref|XM_006227048.2|",1920,0,"PREDICTED: Rattus norvegicus similar to zinc finger protein 101 (LOC691422), transcript variant X1, mRNA","Q8N972",484,{"v":2E-159,"d":"2.00E-159"},"Zinc finger protein 709",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000027240",17,1.430299567,53,3.409513224,0.419502572,-1.253248439,0.000723586,0.000573147,"down","yes","Kndc1","protein_coding","chr1:194690135-194738362:+","gi|564299095|ref|XP_006223762.1|",8487,0,"PREDICTED: protein very KIND isoform X1 [Rattus norvegicus]","gi|145864472|ref|NM_177261.4|",5670,0,"Mus musculus kinase non-catalytic C-lobe domain (KIND) containing 1 (Kndc1), mRNA","Q0KK55",3216,0,"Kinase non-catalytic C-lobe domain-containing protein 1",".",".",".",".","pfam00617","RasGEF","RasGEF domain. Guanine nucleotide exchange factor for Ras-like small GTPases.","GO:0001934|positive regulation of protein phosphorylation;GO:0007264|small GTPase mediated signal transduction;GO:0008150|biological_process;GO:0021707|cerebellar granule cell differentiation;GO:0048814|regulation of dendrite morphogenesis;GO:0050773|regulation of dendrite development;GO:0050790|regulation of catalytic activity;","GO:0005575|cellular_component;GO:0030425|dendrite;GO:0032045|guanyl-nucleotide exchange factor complex;GO:0043025|neuronal cell body;","GO:0003674|molecular_function;GO:0005085|guanyl-nucleotide exchange factor activity;",".","."]
["ENSRNOG00000065478",17,1.430299567,53,3.409513224,0.419502572,-1.253248439,0.000723586,0.000573147,"down","yes","ENSRNOG00000065478","lncRNA","chr6:123983010-123988070:+",".",".",".",".","gi|672057043|ref|XR_146053.3|",349,0,"PREDICTED: Rattus norvegicus uncharacterized LOC100912305 (LOC100912305), ncRNA",".",".",".",".",".",".",".",".","pfam03133","TTL","Tubulin-tyrosine ligase family. Tubulins and microtubules are subjected to several post-translational modifications of which the reversible detyrosination/tyrosination of the carboxy-terminal end of most alpha-tubulins has been extensively analysed. This modification cycle involves a specific carboxypeptidase and the activity of the tubulin-tyrosine ligase (TTL). The true physiological function of TTL has so far not been established. Tubulin-tyrosine ligase (TTL) catalyses the ATP-dependent post-translational addition of a tyrosine to the carboxy terminal end of detyrosinated alpha-tubulin. In normally cycling cells, the tyrosinated form of tubulin predominates. However, in breast cancer cells, the detyrosinated form frequently predominates, with a correlation to tumor aggressiveness. On the other hand, 3-nitrotyrosine has been shown to be incorporated, by TTL, into the carboxy terminal end of detyrosinated alpha-tubulin. This reaction is not reversible by the carboxypeptidase enzyme. Cells cultured in 3-nitrotyrosine rich medium showed evidence of altered microtubule structure and function, including altered cell morphology, epithelial barrier dysfunction, and apoptosis. Bacterial homologs of TTL are predicted to form peptide tags. Some of these are fused to a 2-oxoglutarate Fe(II)-dependent dioxygenase domain.",".",".",".",".","."]
["ENSRNOG00000018143",6,0.504811612,29,1.865582707,0.270591923,-1.88580932,0.000746084,0.000589066,"down","yes","Hpdl","protein_coding","chr5:130286631-130288233:-","gi|62078869|ref|NP_001014090.1|",1895,0,"4-hydroxyphenylpyruvate dioxygenase-like protein [Rattus norvegicus]","gi|62078868|ref|NM_001014068.1|",1600,0,"Rattus norvegicus 4-hydroxyphenylpyruvate dioxygenase-like (Hpdl), mRNA","Q5XIH9",731,0,"4-hydroxyphenylpyruvate dioxygenase-like protein","all0771",106,{"v":2e-24,"d":"2.00E-24"},"COG3185","pfam12681","Glyoxalase_2","Glyoxalase-like domain. This domain is related to the Glyoxalase domain pfam00903.","GO:0009072|aromatic amino acid family metabolic process;","GO:0005739|mitochondrion;","GO:0003868|4-hydroxyphenylpyruvate dioxygenase activity;GO:0046872|metal ion binding;","K24788","HPDL; 4-hydroxyphenylpyruvate dioxygenase-like protein [EC:1.13.-.-]"]
["ENSRNOG00000021916",6,0.504811612,29,1.865582707,0.270591923,-1.88580932,0.000746084,0.000589066,"down","yes","Slc16a12","protein_coding","chr1:232185907-232262141:-","gi|347300453|ref|NP_001178566.1|",2530,0,"monocarboxylate transporter 12 [Rattus norvegicus]","gi|347300452|ref|NM_001191637.1|",1876,0,"Rattus norvegicus solute carrier family 16, member 12 (Slc16a12), mRNA","Q8BGC3",932,0,"Monocarboxylate transporter 12","AF0367",107,{"v":7e-24,"d":"7.00E-24"},"COG0477","pfam07690","MFS_1","Major Facilitator Superfamily.","GO:0008150|biological_process;GO:0015718|monocarboxylic acid transport;GO:0015881|creatine transmembrane transport;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;","GO:0003674|molecular_function;GO:0005308|creatine transmembrane transporter activity;GO:0008028|monocarboxylic acid transmembrane transporter activity;GO:0015293|symporter activity;","K11810","SLC16A12; MFS transporter, MCT family, solute carrier family 16 (monocarboxylic acid transporters), member 12"]
["ENSRNOG00000063019",6,0.504811612,29,1.865582707,0.270591923,-1.88580932,0.000746084,0.000589066,"down","yes","ENSRNOG00000063019","protein_coding","chr1:78365496-78375824:-","gi|672013157|ref|XP_006223150.2|",450,{"v":2E-52,"d":"2.00E-52"},"PREDICTED: homeobox protein goosecoid-like [Rattus norvegicus]","gi|672013156|ref|XM_006223088.2|",316,{"v":6e-163,"d":"6.00E-163"},"PREDICTED: Rattus norvegicus paired box protein Pax-7-like (LOC102553890), mRNA",".",".",".",".",".",".",".",".","pfam00046","Homeobox","Homeobox domain.",".",".",".",".","."]
["ENSRNOG00000065697",3,0.252405806,21,1.350939202,0.18683728,-2.420145747,0.000788254,0.000620758,"down","yes","ENSRNOG00000065697","lncRNA","chr9:105805421-105816652:-","gi|149029743|gb|EDL84900.1|",161,{"v":3e-12,"d":"3.00E-12"},"rCG21031, partial [Rattus norvegicus]","gi|564370085|ref|XR_357299.1|",356,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102554935 (LOC102554935), ncRNA",".",".",".",".",".",".",".",".","pfam00383","dCMP_cyt_deam_1","Cytidine and deoxycytidylate deaminase zinc-binding region.",".",".",".",".","."]
["ENSRNOG00000049495",2,0.168270537,18,1.157947887,0.145317884,-2.782715827,0.000791172,0.000622696,"down","yes","Krt71","protein_coding","chr7:132873540-132882325:-","gi|449310818|ref|NP_001263369.1|",2121,0,"keratin 71 [Rattus norvegicus]","gi|672060279|ref|XM_008765783.1|",2154,0,"PREDICTED: Rattus norvegicus keratin 71 (Krt71), transcript variant X1, mRNA","Q9R0H5",810,0,"Keratin, type II cytoskeletal 71",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0031069|hair follicle morphogenesis;GO:0045109|intermediate filament organization;","GO:0045095|keratin filament;",".","K07605","KRT2; type II keratin, basic"]
["ENSRNOG00000070517",2,0.168270537,18,1.157947887,0.145317884,-2.782715827,0.000791172,0.000622696,"down","yes","Cesl1","protein_coding","chr19:22670712-22712608:-","gi|66730527|ref|NP_001019536.1|",2871,0,"liver carboxylesterase B-1 precursor [Rattus norvegicus]","gi|66730526|ref|NM_001024365.1|",1820,0,"Rattus norvegicus carboxylesterase-like 1 (Cesl1), mRNA","Q63010",1104,0,"Liver carboxylesterase B-1","BS_pnbA",209,{"v":7e-58,"d":"7.00E-58"},"COG2272","pfam00135","COesterase","Carboxylesterase family.",".",".",".",".","."]
["ENSRNOG00000007256",25,2.103381716,68,4.374469797,0.480831235,-1.056397477,0.000838859,0.000657378,"down","yes","Necab1","protein_coding","chr5:28330206-28357152:+","gi|755505878|ref|XP_011248190.1|",624,{"v":7e-73,"d":"7.00E-73"},"PREDICTED: uncharacterized protein C8orf88 homolog isoform X2 [Mus musculus]","gi|295054745|gb|AC109757.5|",1873,0,"Rattus norvegicus BAC CH230-218I7 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P0DMB2",209,{"v":7e-62,"d":"7.00E-62"},"Uncharacterized protein C8orf88",".",".",".",".","pfam03585","Herpes_ICP4_C","Herpesvirus ICP4-like protein C-terminal region. The immediate-early protein ICP4 (infected-cell polypeptide 4) is required for efficient transcription of early and late viral genes and is thus essential for productive infection. ICP4 is a large phosphoprotein that binds DNA in a sequence specific manner as a homodimer. ICP4 represses transcription from LAT, ICP4 and ORF-P that have high-affinity a ICP4 binding site that spans the transcription initiation site. ICP4 proteins have two highly conserved regions, this family contains the C-terminal region that probably acts as an enhancer for the N-terminal region.","GO:0001835|blastocyst hatching;GO:0042984|regulation of amyloid precursor protein biosynthetic process;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0005509|calcium ion binding;GO:0042802|identical protein binding;","K23854","NECAB; N-terminal EF-hand calcium-binding protein"]
["ENSRNOG00000026056",11,0.925487955,40,2.573217527,0.359661764,-1.475287302,0.000879139,0.00068549,"down","yes","Ccnb1ip1","protein_coding","chr15:24014908-24028475:-","gi|564386005|ref|XP_006251963.1|",1583,0,"PREDICTED: E3 ubiquitin-protein ligase CCNB1IP1 isoform X3 [Rattus norvegicus]","gi|672077652|ref|XM_008770567.1|",1784,0,"PREDICTED: Rattus norvegicus cyclin B1 interacting protein 1, E3 ubiquitin protein ligase (Ccnb1ip1), transcript variant X5, mRNA","D3Z3K2",555,0,"E3 ubiquitin-protein ligase CCNB1IP1",".",".",".",".","pfam14634","zf-RING_5","zinc-RING finger domain.","GO:0001825|blastocyst formation;GO:0007131|reciprocal meiotic recombination;GO:0007286|spermatid development;GO:0016567|protein ubiquitination;GO:0051026|chiasma assembly;","GO:0000794|condensed nuclear chromosome;GO:0000795|synaptonemal complex;","GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;","K10639","CCNB1IP1, HEI10; E3 ubiquitin-protein ligase CCNP1IP1 [EC:2.3.2.27]"]
["ENSRNOG00000051819",7,0.588946881,31,1.994243584,0.295323443,-1.759632214,0.000884056,0.000689028,"down","yes","Sdr42e1","protein_coding","chr19:45715399-45727901:-","gi|404312655|ref|NP_001258198.1|",1922,0,"short-chain dehydrogenase/reductase family 42E member 1 [Rattus norvegicus]","gi|404312654|ref|NM_001271269.1|",2536,0,"Rattus norvegicus short chain dehydrogenase/reductase family 42E, member 1 (Sdr42e1), mRNA","Q9D665",659,0,"Short-chain dehydrogenase/reductase family 42E member 1","ML1942",140,{"v":6e-35,"d":"6.00E-35"},"COG0451","pfam01073","3Beta_HSD","3-beta hydroxysteroid dehydrogenase/isomerase family. The enzyme 3 beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase (3 beta-HSD) catalyses the oxidation and isomerization of 5-ene-3 beta-hydroxypregnene and 5-ene-hydroxyandrostene steroid precursors into the corresponding 4-ene-ketosteroids necessary for the formation of all classes of steroid hormones.","GO:0006694|steroid biosynthetic process;","GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;","GO:0003854|3-beta-hydroxy-delta5-steroid dehydrogenase activity;GO:0016616|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;",".","."]
["ENSRNOG00000021175",23,1.935111179,64,4.117148044,0.470012533,-1.089228869,0.000894802,0.000696705,"down","yes","Otub1","protein_coding","chr1:204387215-204395483:-","gi|6841176|gb|AAF28941.1|AF161381_1",1255,{"v":5E-168,"d":"5.00E-168"},"HSPC263 [Homo sapiens]","gi|157821730|ref|NM_001106332.1|",990,0,"Rattus norvegicus OTU deubiquitinase, ubiquitin aldehyde binding 1 (Otub1), mRNA","B2RYG6",485,{"v":1E-168,"d":"1.00E-168"},"Ubiquitin thioesterase OTUB1",".",".",".",".","pfam10275","Peptidase_C65","Peptidase C65 Otubain. This family of proteins conserved from plants to humans is a highly specific ubiquitin iso-peptidase that removes ubiquitin from proteins. The modification of cellular proteins by ubiquitin (Ub) is an important event that underlies protein stability and function in eukaryote being a dynamic and reversible process. Otubain carries several key conserved domains: (i) the OTU (ovarian tumor domain) in which there is an active cysteine protease triad (ii) a nuclear localisation signal, (iii) a Ub interaction motif (UIM)-like motif phi-xx-A-xxxs-xx-Ac (where phi indicates an aromatic amino acid, x indicates any amino acid and Ac indicates an acidic amino acid), (iv) a Ub-associated (UBA)-like domain and (v) the LxxLL motif.","GO:0002250|adaptive immune response;GO:0006281|DNA repair;GO:0006974|cellular response to DNA damage stimulus;GO:0071108|protein K48-linked deubiquitination;GO:0071347|cellular response to interleukin-1;GO:1901315|negative regulation of histone H2A K63-linked ubiquitination;GO:2000780|negative regulation of double-strand break repair;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0003674|molecular_function;GO:0004843|thiol-dependent ubiquitin-specific protease activity;GO:0019784|NEDD8-specific protease activity;GO:0031625|ubiquitin protein ligase binding;GO:0043130|ubiquitin binding;","K09602","OTUB1; ubiquitin thioesterase protein OTUB1 [EC:3.4.19.12]"]
["ENSRNOG00000023412",23,1.935111179,64,4.117148044,0.470012533,-1.089228869,0.000894802,0.000696705,"down","yes","Tmem241","protein_coding","chr18:3168067-3318293:-","gi|564320335|ref|XP_003753072.2|",1520,0,"PREDICTED: transmembrane protein 241 [Rattus norvegicus]","gi|672082832|ref|XM_001057715.5|",1842,0,"PREDICTED: Rattus norvegicus transmembrane protein 241 (Tmem241), mRNA","Q3UME2",522,{"v":1E-180,"d":"1.00E-180"},"Transmembrane protein 241","YGL225w",64.3,{"v":3E-10,"d":"3.00E-10"},"COG5070","pfam08449","UAA","UAA transporter family. This family includes transporters with a specificity for UDP-N-acetylglucosamine.","GO:0055085|transmembrane transport;","GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;","GO:0015297|antiporter activity;",".","."]
["ENSRNOG00000069069",12,1.009623224,42,2.701878404,0.37367456,-1.420145747,0.000923529,0.000716613,"down","yes","ENSRNOG00000069069","protein_coding","chr19:9343901-9344893:-","gi|564394448|ref|XP_006255132.1|",218,{"v":2E-19,"d":"2.00E-19"},"PREDICTED: N-lysine methyltransferase SETD6 isoform X1 [Rattus norvegicus]","gi|672084057|ref|XM_006255070.2|",136,{"v":1e-63,"d":"1.00E-63"},"PREDICTED: Rattus norvegicus SET domain containing 6 (Setd6), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam06097","DUF945","Bacterial protein of unknown function (DUF945). This family consists of several hypothetical bacterial proteins of unknown function.",".",".",".",".","."]
["ENSRNOG00000055361",5,0.420676343,26,1.672591393,0.251511723,-1.991302449,0.00093156,0.000722433,"down","yes","SNORD18","snoRNA","chr8:64673656-64673726:+",".",".",".",".","gi|908663639|tpe|LN872817.1|",65,{"v":9e-25,"d":"9.00E-25"},"TPA: Mus musculus SNORD18 gene for small nucleolar RNA SNORD18",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["ENSRNOG00000000412",20,1.682705373,58,3.731165415,0.450986538,-1.148843726,0.00096366,0.000745628,"down","yes","Slc35f1","protein_coding","chr20:32030368-32418611:+","gi|157819029|ref|NP_001102808.1|",2013,0,"solute carrier family 35 member F1 [Rattus norvegicus]","gi|157819028|ref|NM_001109338.1|",4773,0,"Rattus norvegicus solute carrier family 35, member F1 (Slc35f1), mRNA","Q8BGK5",768,0,"Solute carrier family 35 member F1","SPCC320.08",191,{"v":2E-50,"d":"2.00E-50"},"COG0697","pfam06027","DUF914","Eukaryotic protein of unknown function (DUF914). This family consists of several hypothetical proteins of unknown function. Some of the sequences in this family are annotated as being putative membrane proteins.","GO:0055085|transmembrane transport;","GO:0016021|integral component of membrane;","GO:0022857|transmembrane transporter activity;","K15287","SLC35F1_2; solute carrier family 35, member F1/2"]
["ENSRNOG00000039504",20,1.682705373,58,3.731165415,0.450986538,-1.148843726,0.00096366,0.000745628,"down","yes","ENSRNOG00000039504","protein_coding","chr14:17478443-17525047:-","gi|392332999|ref|XP_003752762.1|",3296,0,"PREDICTED: alpha-fetoprotein isoform X1 [Rattus norvegicus]","gi|672027743|ref|XM_003752714.3|",2349,0,"PREDICTED: Rattus norvegicus similar to alpha-fetoprotein (LOC360919), transcript variant X1, mRNA","Q8MJU5",458,{"v":9e-150,"d":"9.00E-150"},"Alpha-fetoprotein",".",".",".",".","pfam00273","Serum_albumin","Serum albumin family.","GO:0006810|transport;","GO:0005615|extracellular space;GO:0005737|cytoplasm;","GO:0005504|fatty acid binding;GO:0008270|zinc ion binding;",".","."]
["ENSRNOG00000064983",14,1.177893761,46,2.959200157,0.39804464,-1.328997859,0.000980221,0.00075715,"down","yes","ENSRNOG00000064983","processed_pseudogene","chr1:64480247-64481182:+","gi|568906221|ref|XP_006495974.1|",1628,0,"PREDICTED: eukaryotic translation initiation factor 5B isoform X1 [Mus musculus]","gi|225637554|ref|NG_006708.1|",936,0,"Rattus norvegicus vomeronasal 2 receptor, pseudogene 40 (Vom2r-ps40) on chromosome 14","Q05D44",624,0,"Eukaryotic translation initiation factor 5B","SPAC56F8.03",277,{"v":9e-84,"d":"9.00E-84"},"COG0532","pfam11987","IF-2","Translation-initiation factor 2. IF-2 is a translation initiator in each of the three main phylogenetic domains (Eukaryotes, Bacteria and Archaea). IF2 interacts with formylmethionine-tRNA, GTP, IF1, IF3 and both ribosomal subunits. Through these interactions, IF2 promotes the binding of the initiator tRNA to the A site in the smaller ribosomal subunit and catalyses the hydrolysis of GTP following initiation-complex formation.",".",".",".",".","."]
["ENSRNOG00000002792",15,1.26202903,48,3.087861033,0.40870655,-1.29086273,0.000994409,0.000767457,"down","yes","Cxcl2","protein_coding","chr14:17181062-17183075:-","gi|16758460|ref|NP_446099.1|",440,{"v":2E-50,"d":"2.00E-50"},"C-X-C motif chemokine 2 precursor [Rattus norvegicus]","gi|16758459|ref|NM_053647.1|",1041,0,"Rattus norvegicus chemokine (C-X-C motif) ligand 2 (Cxcl2), mRNA","P30348",174,{"v":6E-52,"d":"6.00E-52"},"C-X-C motif chemokine 2",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0001975|response to amphetamine;GO:0002237|response to molecule of bacterial origin;GO:0006954|inflammatory response;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0009408|response to heat;GO:0010332|response to gamma radiation;GO:0030593|neutrophil chemotaxis;GO:0030595|leukocyte chemotaxis;GO:0031640|killing of cells of other organism;GO:0032355|response to estradiol;GO:0042060|wound healing;GO:0051384|response to glucocorticoid;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098|chemokine-mediated signaling pathway;GO:0070997|neuron death;GO:0071222|cellular response to lipopolysaccharide;GO:0071347|cellular response to interleukin-1;","GO:0005615|extracellular space;","GO:0008009|chemokine activity;GO:0045236|CXCR chemokine receptor binding;","K05505","CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3"]
["ENSRNOG00000019093",15,1.26202903,48,3.087861033,0.40870655,-1.29086273,0.000994409,0.000767457,"down","yes","Nrg2","protein_coding","chr18:27619661-27798505:-","gi|3914152|sp|O35569.1|NRG2_RAT",2997,0,"RecName: Full=Pro-neuregulin-2, membrane-bound isoform; Short=Pro-NRG2; Contains: RecName: Full=Neuregulin-2; Short=NRG-2; AltName: Full=Neural- and thymus-derived activator for ERBB kinases; Short=NTAK; Flags: Precursor","gi|209954627|ref|NM_001136151.1|",2976,0,"Rattus norvegicus neuregulin 2 (Nrg2), mRNA","O35569",1159,0,"Pro-neuregulin-2, membrane-bound isoform",".",".",".",".","pfam02158","Neuregulin","Neuregulin family.","GO:0007165|signal transduction;GO:0007173|epidermal growth factor receptor signaling pathway;GO:0007399|nervous system development;GO:0035556|intracellular signal transduction;GO:0048513|animal organ development;GO:0051963|regulation of synapse assembly;GO:0090128|regulation of synapse maturation;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0098978|glutamatergic synapse;GO:0098982|GABA-ergic synapse;","GO:0005006|epidermal growth factor-activated receptor activity;GO:0005102|signaling receptor binding;GO:0005154|epidermal growth factor receptor binding;GO:0008083|growth factor activity;GO:0043125|ErbB-3 class receptor binding;","K05456","NRG2; neuregulin 2"]
["ENSRNOG00000015797",17,1.430299567,52,3.345182786,0.427569929,-1.225767702,0.000999564,0.000770998,"down","yes","Neurl2","protein_coding","chr3:153566660-153569380:-","gi|157821687|ref|NP_001101272.1|",1486,0,"neuralized-like protein 2 [Rattus norvegicus]","gi|442734429|ref|NM_001107802.2|",1456,0,"Rattus norvegicus neuralized E3 ubiquitin protein ligase 2 (Neurl2), mRNA","Q9D0S4",546,0,"Neuralized-like protein 2",".",".",".",".","pfam07177","Neuralized","Neuralized. This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.","GO:0008150|biological_process;GO:0016567|protein ubiquitination;GO:0030239|myofibril assembly;GO:0035556|intracellular signal transduction;GO:0045214|sarcomere organization;","GO:0005575|cellular_component;GO:0005927|muscle tendon junction;GO:0030891|VCB complex;","GO:0003674|molecular_function;GO:0061630|ubiquitin protein ligase activity;","K16782","NEURL2; neuralized-like protein 2"]
["ENSRNOG00000030788",17,1.430299567,52,3.345182786,0.427569929,-1.225767702,0.000999564,0.000770998,"down","yes","Olr35","protein_coding","chr1:154041306-154043257:+","gi|47577201|ref|NP_001000121.1|",1277,{"v":2E-171,"d":"2.00E-171"},"olfactory receptor Olr35 [Rattus norvegicus]","gi|51372035|gb|AC115040.7|",967,0,"Mus musculus chromosome 7, clone RP24-281E19, complete sequence","A6NND4",433,{"v":3E-148,"d":"3.00E-148"},"Olfactory receptor 2AT4",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0050911|detection of chemical stimulus involved in sensory perception of smell;GO:0070374|positive regulation of ERK1 and ERK2 cascade;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004984|olfactory receptor activity;","K04257","OLFR; olfactory receptor"]
["ENSRNOG00000003581",8,0.673082149,33,2.12290446,0.317057202,-1.657184945,0.0010063,0.000775913,"down","yes","Pou2f1","protein_coding","chr13:78130685-78263363:-","gi|672074259|ref|XP_008767813.1|",2033,0,"PREDICTED: POU domain, class 2, transcription factor 1 isoform X1 [Rattus norvegicus]","gi|672074258|ref|XM_008769591.1|",2531,0,"PREDICTED: Rattus norvegicus POU class 2 homeobox 1 (Pou2f1), transcript variant X2, mRNA","Q29076",710,0,"POU domain, class 2, transcription factor 1",".",".",".",".","pfam00157","Pou","Pou domain - N-terminal to homeobox domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0010629|negative regulation of gene expression;GO:0030910|olfactory placode formation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0060235|lens induction in camera-type eye;GO:0097421|liver regeneration;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005783|endoplasmic reticulum;GO:0043231|intracellular membrane-bounded organelle;GO:0090575|RNA polymerase II transcription factor complex;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000979|RNA polymerase II core promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0005102|signaling receptor binding;GO:0042802|identical protein binding;GO:0043565|sequence-specific DNA binding;","K09364","POU2F, OTF; POU domain transcription factor, class 2"]
["ENSRNOG00000027767",4,0.336541075,23,1.479600078,0.22745408,-2.136352781,1.124115E-3,0.00085823,"down","yes","Slc38a5","protein_coding","chrX:14213729-14222498:-","gi|20302002|ref|NP_620209.1|",1984,0,"sodium-coupled neutral amino acid transporter 5 [Rattus norvegicus]","gi|20302001|ref|NM_138854.1|",1831,0,"Rattus norvegicus solute carrier family 38, member 5 (Slc38a5), mRNA","A2VCW5",768,0,"Sodium-coupled neutral amino acid transporter 5",".",".",".",".","pfam01490","Aa_trans","Transmembrane amino acid transporter protein. This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.","GO:0003333|amino acid transmembrane transport;GO:0006867|asparagine transport;GO:0006868|glutamine transport;GO:0015804|neutral amino acid transport;GO:0015816|glycine transport;GO:0015825|L-serine transport;GO:0032329|serine transport;GO:0089709|L-histidine transmembrane transport;GO:1903713|asparagine transmembrane transport;GO:1904557|L-alanine transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;","GO:0005290|L-histidine transmembrane transporter activity;GO:0015171|amino acid transmembrane transporter activity;GO:0015175|neutral amino acid transmembrane transporter activity;GO:0015182|L-asparagine transmembrane transporter activity;GO:0015186|L-glutamine transmembrane transporter activity;GO:0015187|glycine transmembrane transporter activity;GO:0015194|L-serine transmembrane transporter activity;GO:0022858|alanine transmembrane transporter activity;GO:0022889|serine transmembrane transporter activity;","K14992","SLC38A5, SNAT5; solute carrier family 38 (sodium-coupled neutral amino acid transporter), member 5"]
["ENSRNOG00000063759",4,0.336541075,23,1.479600078,0.22745408,-2.136352781,1.124115E-3,0.00085823,"down","yes","ENSRNOG00000063759","lncRNA","chr9:106024644-106026682:-","gi|56789200|gb|AAH88270.1|",147,5e-08,"Wash2 protein [Rattus norvegicus]","gi|672033602|ref|XM_008758262.1|",553,0,"PREDICTED: Rattus norvegicus WAS protein family homolog (Wash), transcript variant X1, mRNA","Q8VDD8",60.5,2E-8,"WASH complex subunit 1",".",".",".",".","pfam15557","CAF1-p150_N","CAF1 complex subunit p150, region binding to PCNA. CAF1-p150_N is part of the N-terminus of the CAF1 complex p150 subunit that binds to PCNA - proliferating cell nuclear antigen. The PCNA mediates the connection between CAF-1 and the DNA replication fork. The CAF1 complex is essential in human cells for the de novo deposition of histones H3 and H4 at the DNA replication fork.",".",".",".",".","."]
["ENSRNOG00000015401",1,0.084135269,14,0.900626135,0.09341864,-3.420145747,0.001125405,0.000858937,"down","yes","Mapk4","protein_coding","chr18:67512807-67661842:-","gi|402794629|ref|NP_062192.1|",3015,0,"mitogen-activated protein kinase 4 [Rattus norvegicus]","gi|672083546|ref|XM_008772166.1|",4545,0,"PREDICTED: Rattus norvegicus mitogen-activated protein kinase 4 (Mapk4), transcript variant X1, mRNA","Q6P5G0",1152,0,"Mitogen-activated protein kinase 4",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0000165|MAPK cascade;GO:0006468|protein phosphorylation;GO:0035556|intracellular signal transduction;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0004674|protein serine/threonine kinase activity;GO:0004707|MAP kinase activity;GO:0005524|ATP binding;GO:0019901|protein kinase binding;GO:0042803|protein homodimerization activity;GO:0046982|protein heterodimerization activity;","K06855","MAPK4_6; mitogen-activated protein kinase 4/6 [EC:2.7.11.24]"]
["ENSRNOG00000069467",1,0.084135269,14,0.900626135,0.09341864,-3.420145747,0.001125405,0.000858937,"down","yes","ENSRNOG00000069467","protein_coding","chr11:64896331-64896753:+","gi|149025948|gb|EDL82191.1|",305,{"v":6e-33,"d":"6.00E-33"},"caspase 6, isoform CRA_b [Rattus norvegicus]","gi|672044118|ref|XM_008761477.1|",147,{"v":1e-69,"d":"1.00E-69"},"PREDICTED: Rattus norvegicus caspase-6 (LOC103689977), transcript variant X2, mRNA","O08738",119,{"v":8e-33,"d":"8.00E-33"},"Caspase-6",".",".",".",".","pfam00656","Peptidase_C14","Caspase domain.",".",".",".",".","."]
["ENSRNOG00000019361",6,0.504811612,28,1.801252269,0.28025592,-1.835183247,0.001142453,0.000870956,"down","yes","Inpp5j","protein_coding","chr14:78374161-78385326:-","gi|564384167|ref|XP_006251217.1|",3771,0,"PREDICTED: phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform X1 [Rattus norvegicus]","gi|672076538|ref|XM_006251155.2|",3344,0,"PREDICTED: Rattus norvegicus inositol polyphosphate-5-phosphatase J (Inpp5j), transcript variant X1, mRNA","Q9JMC1",1450,0,"Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A","SPBC2G2.02_2",156,{"v":6e-39,"d":"6.00E-39"},"COG5411","pfam03372","Exo_endo_phos","Endonuclease/Exonuclease/phosphatase family. This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins EC:4.2.99.18, DNase I proteins EC:3.1.21.1, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56, Sphingomyelinase EC:3.1.4.12 and Nocturnin.","GO:0010977|negative regulation of neuron projection development;GO:0031115|negative regulation of microtubule polymerization;GO:0033137|negative regulation of peptidyl-serine phosphorylation;GO:0046855|inositol phosphate dephosphorylation;GO:0046856|phosphatidylinositol dephosphorylation;","GO:0001726|ruffle;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0019898|extrinsic component of membrane;GO:0030426|growth cone;GO:0043198|dendritic shaft;","GO:0004439|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0004445|inositol-polyphosphate 5-phosphatase activity;GO:0017124|SH3 domain binding;GO:0034485|phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity;GO:0052658|inositol-1,4,5-trisphosphate 5-phosphatase activity;GO:0052659|inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity;","K24222","INPP5J_K; inositol polyphosphate 5-phosphatase INPP5J/K [EC:3.1.3.56]"]
["ENSRNOG00000056287",6,0.504811612,28,1.801252269,0.28025592,-1.835183247,0.001142453,0.000870956,"down","yes","Snora26","snoRNA","chr14:34127640-34127760:-","gi|26337233|dbj|BAC32301.1|",189,{"v":1e-16,"d":"1.00E-16"},"unnamed protein product [Mus musculus]","gi|222350115|emb|FM991919.1|",106,{"v":3e-47,"d":"3.00E-47"},"Mus musculus AK172090 snRNA, strain C57BL/6J",".",".",".",".",".",".",".",".","pfam12834","Phage_int_SAM_2","Phage integrase, N-terminal. This is a family of DNA-binding prophage integrases. It is found largely in Proteobacteria.",".",".",".",".","."]
["ENSRNOG00000064838",6,0.504811612,28,1.801252269,0.28025592,-1.835183247,0.001142453,0.000870956,"down","yes","ENSRNOG00000064838","protein_coding","chr2:23582194-23585966:-","gi|300794684|ref|NP_001178886.1|",841,{"v":1e-101,"d":"1.00E-101"},"DNA mismatch repair protein Msh3 [Rattus norvegicus]","gi|672041094|ref|XM_006231768.2|",602,0,"PREDICTED: Rattus norvegicus mutS homolog 3 (Msh3), transcript variant X1, mRNA","P13705",281,{"v":5e-86,"d":"5.00E-86"},"DNA mismatch repair protein Msh3",".",".",".",".","pfam12349","Sterol-sensing","Sterol-sensing domain of SREBP cleavage-activation. Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.",".",".",".",".","."]
["ENSRNOG00000018764",0,0.042067634,12,0.771965258,0.054494207,-4.197753326,0.001218321,0.00092441,"down","yes","B3gnt3","protein_coding","chr16:18401405-18410766:-","gi|157823527|ref|NP_001099538.1|",1918,0,"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 precursor [Rattus norvegicus]","gi|157823526|ref|NM_001106068.1|",2160,0,"Rattus norvegicus UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 (B3gnt3), mRNA","Q5JCS9",616,0,"N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3",".",".",".",".","pfam01762","Galactosyl_T","Galactosyltransferase. This family includes the galactosyltransferases UDP-galactose:2-acetamido-2-deoxy-D-glucose3beta-galactosyltransferase and UDP-Gal:beta-GlcNAc beta 1,3-galactosyltranferase. Specific galactosyltransferases transfer galactose to GlcNAc terminal chains in the synthesis of the lacto-series oligosaccharides types 1 and 2.","GO:0006486|protein glycosylation;GO:0030311|poly-N-acetyllactosamine biosynthetic process;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0008194|UDP-glycosyltransferase activity;GO:0008532|N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity;GO:0016757|transferase activity, transferring glycosyl groups;","K07970","B3GNT3; beta-1,3-N-acetylglucosaminyltransferase 3 [EC:2.4.1.146 2.4.1.149]"]
["ENSRNOG00000021833",0,0.042067634,12,0.771965258,0.054494207,-4.197753326,0.001218321,0.00092441,"down","yes","Myrfl","protein_coding","chr7:52403650-52519907:-","gi|672021719|ref|XP_008774669.1|",4459,0,"PREDICTED: myelin regulatory factor-like protein isoform X1 [Rattus norvegicus]","gi|672021718|ref|XM_008776447.1|",2679,0,"PREDICTED: Rattus norvegicus myelin regulatory factor-like (Myrfl), transcript variant X1, mRNA","Q3UN70",1568,0,"Myelin regulatory factor-like protein",".",".",".",".","pfam13888","MRF_C2","Myelin gene regulatory factor C-terminal domain 2. This domain is found further downstream of Peptidase_S74, pfam13884, and MRF_C1, pfam13887. The function is not known.","GO:0016540|protein autoprocessing;GO:0045893|positive regulation of transcription, DNA-templated;","GO:0005634|nucleus;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0003700|DNA-binding transcription factor activity;GO:0043565|sequence-specific DNA binding;",".","."]
["ENSRNOG00000031927",0,0.042067634,12,0.771965258,0.054494207,-4.197753326,0.001218321,0.00092441,"down","yes","Klk6","protein_coding","chr1:94280340-94286121:+","gi|9506997|ref|NP_062048.1|",1349,0,"kallikrein-6 precursor [Rattus norvegicus]","gi|672036301|ref|XM_006228982.2|",897,0,"PREDICTED: Rattus norvegicus kallikrein related-peptidase 6 (Klk6), transcript variant X1, mRNA","Q92876",361,{"v":7e-124,"d":"7.00E-124"},"Kallikrein-6","mlr3307",117,{"v":3e-29,"d":"3.00E-29"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;GO:0010975|regulation of neuron projection development;GO:0045745|positive regulation of G protein-coupled receptor signaling pathway;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005737|cytoplasm;GO:0030141|secretory granule;","GO:0004252|serine-type endopeptidase activity;GO:0008233|peptidase activity;","K08667","KLK6, PRSS9; kallikrein 6 [EC:3.4.21.-]"]
["ENSRNOG00000050521",0,0.042067634,12,0.771965258,0.054494207,-4.197753326,0.001218321,0.00092441,"down","yes","Tspo2","protein_coding","chr9:12545015-12548573:+","gi|672023682|ref|XP_008756173.1|",715,{"v":9e-92,"d":"9.00E-92"},"PREDICTED: translocator protein 2 isoform X3 [Rattus norvegicus]","gi|672064444|ref|XM_008766892.1|",698,0,"PREDICTED: Rattus norvegicus translocator protein 2 (Tspo2), transcript variant X2, mRNA","Q9CRZ8",241,{"v":9e-79,"d":"9.00E-79"},"Translocator protein 2","SMa1079",47.8,5e-06,"COG3476","pfam03073","TspO_MBR","TspO/MBR family. Tryptophan-rich sensory protein (TspO) is an integral membrane protein that acts as a negative regulator of the expression of specific photosynthesis genes in response to oxygen/light. It is involved in the efflux of porphyrin intermediates from the cell. This reduces the activity of coproporphyrinogen III oxidase, which is thought to lead to the accumulation of a putative repressor molecule that inhibits the expression of specific photosynthesis genes. Several conserved aromatic residues are necessary for TspO function: they are thought to be involved in binding porphyrin intermediates. In, the rat mitochondrial peripheral benzodiazepine receptor (MBR) was shown to not only retain its structure within a bacterial outer membrane, but also to be able to functionally substitute for TspO in TspO- mutants, and to act in a similar manner to TspO in its in situ location: the outer mitochondrial membrane. The biological significance of MBR remains unclear, however. It is thought to be involved in a variety of cellular functions, including cholesterol transport in steroidogenic tissues.","GO:0032367|intracellular cholesterol transport;GO:0034389|lipid droplet organization;GO:0043353|enucleate erythrocyte differentiation;GO:0089718|amino acid import across plasma membrane;GO:0098739|import across plasma membrane;","GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0031090|organelle membrane;","GO:0015485|cholesterol binding;",".","."]
["ENSRNOG00000065740",0,0.042067634,12,0.771965258,0.054494207,-4.197753326,0.001218321,0.00092441,"down","yes","Myh2","protein_coding","chr10:51856738-51883236:+","gi|205830436|ref|NP_001128629.1|",9186,0,"myosin heavy chain IIa [Rattus norvegicus]","gi|205830435|ref|NM_001135157.1|",6041,0,"Rattus norvegicus myosin, heavy chain 2, skeletal muscle, adult (Myh2), mRNA","Q076A7",3490,0,"Myosin-2","SPCC645.05c",749,0,"COG5022","pfam01576","Myosin_tail_1","Myosin tail. The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.",".",".",".",".","."]
["ENSRNOG00000070802",0,0.042067634,12,0.771965258,0.054494207,-4.197753326,0.001218321,0.00092441,"down","yes","ENSRNOG00000070802","protein_coding","chr15:51432883-51433062:-","gi|90086087|dbj|BAE91596.1|",240,{"v":4e-25,"d":"4.00E-25"},"unnamed protein product [Macaca fascicularis]","gi|672069359|ref|XM_006247472.2|",159,{"v":2e-76,"d":"2.00E-76"},"PREDICTED: Rattus norvegicus ataxin 7-like 3 (Atxn7l3), transcript variant X6, mRNA",".",".",".",".",".",".",".",".","pfam07590","DUF1556","Protein of unknown function (DUF1556).",".",".",".",".","."]
["ENSRNOG00000065187",11,0.925487955,39,2.508887089,0.368883861,-1.438761426,0.001265173,0.000957958,"down","yes","ENSRNOG00000065187","protein_coding","chr8:57909697-57913141:+","gi|690448686|ref|XP_009324661.1|",177,{"v":8E-14,"d":"8.00E-14"},"PREDICTED: 60S ribosomal protein L12 [Pygoscelis adeliae]","gi|751662876|ref|NG_041833.1|",111,{"v":2e-49,"d":"2.00E-49"},"Rattus norvegicus ribosomal protein L12, pseudogene 1 (Rpl12-ps1) on chromosome 8","P30050",69.3,{"v":4E-14,"d":"4.00E-14"},"60S ribosomal protein L12","SPCC31H12.04c",58.2,{"v":9e-11,"d":"9.00E-11"},"COG0080","pfam03946","Ribosomal_L11_N","Ribosomal protein L11, N-terminal domain. The N-terminal domain of Ribosomal protein L11 adopts an alpha/beta fold and is followed by the RNA binding C-terminal domain.",".",".",".",".","."]
["ENSRNOG00000068516",21,1.766840642,59,3.795495853,0.465509833,-1.103116452,0.001272197,0.000962874,"down","yes","Hist1h2ail1","protein_coding","chr17:41568471-41569109:-","gi|562869414|ref|XP_006162733.1|",715,{"v":4e-93,"d":"4.00E-93"},"PREDICTED: histone H3.1 [Tupaia chinensis]","gi|298889922|emb|FQ227095.1|",623,0,"Rattus norvegicus TL0AEA15YD03 mRNA sequence","Q6LED0",274,{"v":1e-92,"d":"1.00E-92"},"Histone H3.1",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.",".",".",".",".","."]
["ENSRNOG00000037348",20,1.682705373,57,3.666834977,0.458898582,-1.123752745,1.305238E-3,0.000985416,"down","yes","AABR07003187.1","protein_coding","chr1:93693837-93694943:-","gi|56090375|ref|NP_001007742.1|",1686,0,"interferon-stimulated 20 kDa exonuclease-like 2 [Rattus norvegicus]","gi|56090374|ref|NM_001007741.1|",1066,0,"Rattus norvegicus interferon stimulated exonuclease gene 20-like 2 (Isg20l2), mRNA","Q6AXU3",654,0,"Interferon-stimulated 20 kDa exonuclease-like 2","YOL080c",139,{"v":4e-37,"d":"4.00E-37"},"COG0847","pfam00929","RNase_T","Exonuclease. This family includes a variety of exonuclease proteins, such as ribonuclease T and the epsilon subunit of DNA polymerase III.;",".",".",".",".","."]
["ENSRNOG00000002126",12,1.009623224,41,2.637547966,0.382788574,-1.385380329,1.316617E-3,0.000993043,"down","yes","Ncam2","protein_coding","chr11:20104925-20591984:+","gi|42821116|ref|NP_981954.1|",3844,0,"neural cell adhesion molecule 2 precursor [Rattus norvegicus]","gi|42821115|ref|NM_203409.1|",4078,0,"Rattus norvegicus neural cell adhesion molecule 2 (Ncam2), mRNA","O35136",1479,0,"Neural cell adhesion molecule 2",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0007155|cell adhesion;GO:0007413|axonal fasciculation;GO:0007608|sensory perception of smell;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016604|nuclear body;GO:0030424|axon;GO:0043005|neuron projection;","GO:0042802|identical protein binding;","K06491","NCAM, CD56; neural cell adhesion molecule"]
["ENSRNOG00000009436",12,1.009623224,41,2.637547966,0.382788574,-1.385380329,1.316617E-3,0.000993043,"down","yes","Hemgn","protein_coding","chr5:60679633-60698669:-","gi|672052524|ref|XP_008761915.1|",2627,0,"PREDICTED: hemogen isoform X1 [Rattus norvegicus]","gi|672052525|ref|XM_008763694.1|",2639,0,"PREDICTED: Rattus norvegicus hemogen (Hemgn), transcript variant X2, mRNA","Q6AZ54",1016,0,"Hemogen",".",".",".",".","pfam11489","DUF3210","Protein of unknown function (DUF3210). This is a family of proteins conserved in yeasts. The function is not known. The Schizosaccharomyces pombe member is SPBC18E5.07 and the Saccharomyces cerevisiae member is AIM21.","GO:0030154|cell differentiation;GO:0045667|regulation of osteoblast differentiation;","GO:0005654|nucleoplasm;",".",".","."]
["ENSRNOG00000060290",7,0.588946881,30,1.929913146,0.305167557,-1.712326499,1.330887E-3,0.001002556,"down","yes","Snord87","snoRNA","chr5:9297489-9297573:+",".",".",".",".","gi|18139791|gb|AF396685.1|",85,{"v":9e-36,"d":"9.00E-36"},"Rattus norvegicus C/D box U87 snoRNA gene, complete sequence",".",".",".",".",".",".",".",".","pfam09642","YonK","YonK protein. YonK protein is expressed by the bacterial prophage SPbetaC. It is a 63 residue protein that associates into a homo-octamer in the form of a beta-stranded barrel with four outer helical features at points of the compass. Its function is unknown.",".",".",".",".","."]
["ENSRNOG00000017510",17,1.430299567,51,3.280852347,0.435953653,-1.197753326,1.374889E-3,1.033843E-3,"down","yes","Mfge8","protein_coding","chr1:133064665-133080073:-","gi|93277126|ref|NP_001035276.1|",2309,0,"lactadherin isoform 1 precursor [Rattus norvegicus]","gi|403310694|ref|NM_001040186.2|",2150,0,"Rattus norvegicus milk fat globule-EGF factor 8 protein (Mfge8), transcript variant 1, mRNA","P21956",824,0,"Lactadherin",".",".",".",".","pfam00754","F5_F8_type_C","F5/8 type C domain. This domain is also known as the discoidin (DS) domain family.","GO:0001525|angiogenesis;GO:0006910|phagocytosis, recognition;GO:0006911|phagocytosis, engulfment;GO:0007155|cell adhesion;GO:0007338|single fertilization;GO:0008284|positive regulation of cell proliferation;GO:0043277|apoptotic cell clearance;GO:0043627|response to estrogen;GO:0050766|positive regulation of phagocytosis;","GO:0002080|acrosomal membrane;GO:0005615|extracellular space;GO:0009897|external side of plasma membrane;GO:0019897|extrinsic component of plasma membrane;","GO:0001786|phosphatidylserine binding;GO:0005178|integrin binding;GO:0008429|phosphatidylethanolamine binding;","K17253","MFGE8; lactadherin"]
["ENSRNOG00000010205",15,1.26202903,47,3.023530595,0.417402434,-1.260489081,0.001384966,1.040558E-3,"down","yes","Mturn","protein_coding","chr4:83807579-83824950:+","gi|56090335|ref|NP_001007646.1|",653,{"v":1E-79,"d":"1.00E-79"},"maturin [Rattus norvegicus]","gi|56090334|ref|NM_001007645.1|",1578,0,"Rattus norvegicus maturin, neural progenitor differentiation regulator homolog (Xenopus) (Mturn), mRNA","Q5XI20",256,{"v":3e-81,"d":"3.00E-81"},"Maturin",".",".",".",".","pfam15167","DUF4581","Domain of unknown function (DUF4581). This family of proteins is found in eukaryotes. Proteins in this family are typically 131 amino acids in length.","GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0045654|positive regulation of megakaryocyte differentiation;GO:0046330|positive regulation of JNK cascade;GO:0070374|positive regulation of ERK1 and ERK2 cascade;","GO:0005737|cytoplasm;",".",".","."]
["ENSRNOG00000015055",5,0.420676343,25,1.608260955,0.261572192,-1.93471892,0.001447686,1.085435E-3,"down","yes","Scg2","protein_coding","chr9:80803075-80821097:-","gi|672065469|ref|XP_008765417.1|",3171,0,"PREDICTED: secretogranin-2 isoform X1 [Rattus norvegicus]","gi|672065468|ref|XM_008767195.1|",2657,0,"PREDICTED: Rattus norvegicus secretogranin II (Scg2), transcript variant X1, mRNA","P10362",1224,0,"Secretogranin-2",".",".",".",".","pfam01271","Granin","Granin (chromogranin or secretogranin).","GO:0000165|MAPK cascade;GO:0001525|angiogenesis;GO:0001938|positive regulation of endothelial cell proliferation;GO:0035556|intracellular signal transduction;GO:0048245|eosinophil chemotaxis;GO:0050918|positive chemotaxis;GO:0050930|induction of positive chemotaxis;GO:2000352|negative regulation of endothelial cell apoptotic process;GO:2001237|negative regulation of extrinsic apoptotic signaling pathway;","GO:0005615|extracellular space;GO:0030141|secretory granule;GO:0031045|dense core granule;GO:0098992|neuronal dense core vesicle;","GO:0005125|cytokine activity;GO:0042056|chemoattractant activity;",".","."]
["ENSRNOG00000019937",5,0.420676343,25,1.608260955,0.261572192,-1.93471892,0.001447686,1.085435E-3,"down","yes","Kcnk1","protein_coding","chr19:53959657-53997724:+","gi|11067417|ref|NP_067720.1|",1376,0,"potassium channel subfamily K member 1 [Rattus norvegicus]","gi|38511568|gb|BC061807.1|",2202,0,"Rattus norvegicus potassium channel, subfamily K, member 1, mRNA (cDNA clone MGC:72470 IMAGE:5598415), complete cds","Q9Z2T2",534,0,"Potassium channel subfamily K member 1",".",".",".",".","pfam07885","Ion_trans_2","Ion channel. This family includes the two membrane helix type ion channels found in bacteria.","GO:0030322|stabilization of membrane potential;GO:0035094|response to nicotine;GO:0035725|sodium ion transmembrane transport;GO:0060075|regulation of resting membrane potential;GO:0071805|potassium ion transmembrane transport;","GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0030425|dendrite;GO:0031526|brush border membrane;GO:0034705|potassium channel complex;GO:0043204|perikaryon;GO:0043231|intracellular membrane-bounded organelle;GO:0055037|recycling endosome;GO:0097060|synaptic membrane;GO:1902937|inward rectifier potassium channel complex;","GO:0005242|inward rectifier potassium channel activity;GO:0005267|potassium channel activity;GO:0005272|sodium channel activity;GO:0022841|potassium ion leak channel activity;GO:0042802|identical protein binding;","K04912","KCNK1, K2P1.1; potassium channel subfamily K member 1"]
["ENSRNOG00000068340",8,0.673082149,32,2.058574022,0.32696524,-1.612790825,0.001492544,0.001116608,"down","yes","ENSRNOG00000068340","lncRNA","chr4:117675777-117682519:+","gi|564303945|ref|XP_006225032.1|",494,{"v":2E-55,"d":"2.00E-55"},"PREDICTED: uncharacterized protein LOC102554508 [Rattus norvegicus]","gi|672050314|ref|XR_353419.2|",736,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102554796 (LOC102554796), transcript variant X3, ncRNA",".",".",".",".",".",".",".",".","pfam15499","Peptidase_C98","Ubiquitin-specific peptidase-like, SUMO isopeptidase. Peptidase_C98 is a small family of SUMO - small ubiquitin-related modifier - isopeptidases found in eukaryotes. Reversible attachment of SUMO is an essential protein modification in all eukaryotic cells, The family neither binds nor cleaves ubiquitin, but is a potent SUMO isopeptidase, and the invariant residues required for SUMO binding and cleavage, in UniProtKB:Q5W0Q7, are Cys-236, His-456 and Asp-472, all of which are fully conserved in the family. Member proteins are low-abundance proteins that colocalize with coilin in Cajal bodies. Peptidase_C98 depletion does not affect global sumoylation, but causes striking coilin mis-localisation and impairs cell proliferation, functions that are not dependent on the catalytic activity. Thus, Peptidase_C98 represents a third type of SUMO protease, with essential functions in Cajal body biology.",".",".",".",".","."]
["ENSRNOG00000069729",8,0.673082149,32,2.058574022,0.32696524,-1.612790825,0.001492544,0.001116608,"down","yes","ENSRNOG00000069729","lncRNA","chr1:181002798-181008230:-","gi|68061395|ref|XP_672697.1|",233,{"v":1e-19,"d":"1.00E-19"},"hypothetical protein [Plasmodium berghei strain ANKA] [Plasmodium berghei ANKA]","gi|354795669|gb|JN960170.1|",678,0,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Rabep2:tm1e(EUCOMM)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam02994","Transposase_22","L1 transposable element.",".",".",".",".","."]
["ENSRNOG00000007799",24,2.019246448,64,4.117148044,0.49044786,-1.027828325,0.001535157,1.146282E-3,"down","yes","Fam151a","protein_coding","chr5:121514804-121527555:+","gi|53850644|ref|NP_001005558.1|",3182,0,"protein FAM151A [Rattus norvegicus]","gi|53850643|ref|NM_001005558.1|",1884,0,"Rattus norvegicus family with sequence similarity 151, member A (Fam151a), mRNA","Q642A7",1230,0,"Protein FAM151A",".",".",".",".","pfam10223","DUF2181","Uncharacterized conserved protein (DUF2181). This is region of approximately 250 residues conserved from worms to humans. Its function is unknown.",".","GO:0005615|extracellular space;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000032664",23,1.935111179,62,3.988487167,0.485174227,-1.04342518,1.594923E-3,1.189116E-3,"down","yes","RT1-S2","protein_coding","chr20:2649964-2652027:+","gi|57012392|ref|NP_001008857.1|",763,{"v":2e-97,"d":"2.00E-97"},"RT1 class Ib, locus S2 precursor [Rattus norvegicus]","gi|672085586|ref|XM_008772705.1|",804,0,"PREDICTED: Rattus norvegicus RT1 class Ib, locus S2 (RT1-S2), transcript variant X1, mRNA","P01896",190,{"v":9e-57,"d":"9.00E-57"},"H-2 class I histocompatibility antigen, alpha chain (Fragment)",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.",".",".",".","K06751","MHC1; MHC class I antigen"]
["ENSRNOG00000011133",10,0.841352686,36,2.315895775,0.363294711,-1.460787732,1.731888E-3,1.284898E-3,"down","yes","Trpc4","protein_coding","chr2:138308084-138476768:+","gi|32189352|ref|NP_536321.1|",4889,0,"short transient receptor potential channel 4 isoform alpha [Rattus norvegicus]","gi|672042409|ref|XM_006232356.2|",3470,0,"PREDICTED: Rattus norvegicus transient receptor potential cation channel, subfamily C, member 4 (Trpc4), transcript variant X1, mRNA","O35119",1881,0,"Short transient receptor potential channel 4",".",".",".",".","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0006816|calcium ion transport;GO:0006828|manganese ion transport;GO:0014051|gamma-aminobutyric acid secretion;GO:0048709|oligodendrocyte differentiation;GO:0051480|regulation of cytosolic calcium ion concentration;GO:0051924|regulation of calcium ion transport;GO:0070509|calcium ion import;GO:0070588|calcium ion transmembrane transport;GO:0099605|regulation of action potential firing rate;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005901|caveola;GO:0005911|cell-cell junction;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0030863|cortical cytoskeleton;GO:0032991|protein-containing complex;GO:0034703|cation channel complex;GO:0034704|calcium channel complex;GO:0045121|membrane raft;","GO:0005262|calcium channel activity;GO:0008013|beta-catenin binding;GO:0015279|store-operated calcium channel activity;GO:0045296|cadherin binding;GO:0070679|inositol 1,4,5 trisphosphate binding;","K04967","TRPC4; transient receptor potential cation channel subfamily C member 4"]
["ENSRNOG00000067988",10,0.841352686,36,2.315895775,0.363294711,-1.460787732,1.731888E-3,1.284898E-3,"down","yes","Slc5a3","protein_coding","chr11:31295476-31318883:+","gi|82617598|ref|NP_446167.2|",3633,0,"sodium/myo-inositol cotransporter [Rattus norvegicus]","gi|354783954|gb|JN948455.1|",2790,0,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Slc5a3:tm1e(KOMP)Wtsi; transgenic","Q9JKZ2",1362,0,"Sodium/myo-inositol cotransporter","BH2222",184,{"v":4e-47,"d":"4.00E-47"},"COG4146","pfam00474","SSF","Sodium:solute symporter family. Membership of this family is supported by a significant blast score.",".",".",".",".","."]
["ENSRNOG00000031290",6,0.504811612,27,1.736921831,0.290635769,-1.782715827,1.740501E-3,1.290233E-3,"down","yes","Trappc3l","protein_coding","chr20:25967502-26078989:+","gi|26324706|dbj|BAC26107.1|",922,{"v":1e-112,"d":"1.00E-112"},"unnamed protein product [Mus musculus]","gi|298913382|emb|FQ214407.1|",1026,0,"Rattus norvegicus TL0AAA41YN21 mRNA sequence","Q4KL14",343,{"v":3e-110,"d":"3.00E-110"},"Trafficking protein particle complex subunit 3-like protein",".",".",".",".","pfam14798","Ca_hom_mod","Calcium homeostasis modulator. This family of proteins control cytosolic calcium concentration. They are transmembrane proteins which may be pore-forming ion channels.","GO:0006888|ER to Golgi vesicle-mediated transport;GO:0006891|intra-Golgi vesicle-mediated transport;","GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;GO:0030008|TRAPP complex;GO:0033106|cis-Golgi network membrane;",".","K20302","TRAPPC3, BET3; trafficking protein particle complex subunit 3"]
["ENSRNOG00000038055",6,0.504811612,27,1.736921831,0.290635769,-1.782715827,1.740501E-3,1.290233E-3,"down","yes","Slc47a2","protein_coding","chr10:45991095-46033904:-","gi|300793956|ref|NP_001178849.1|",2849,0,"multidrug and toxin extrusion protein 2 [Rattus norvegicus]","gi|672067997|ref|XM_008767850.1|",1912,0,"PREDICTED: Rattus norvegicus solute carrier family 47 (multidrug and toxin extrusion), member 2 (Slc47a2), transcript variant X1, mRNA","Q3V050",1036,0,"Multidrug and toxin extrusion protein 2","SPCC4B3.13",250,{"v":3e-72,"d":"3.00E-72"},"COG0534","pfam01554","MatE","MatE. The MatE domain","GO:0008150|biological_process;GO:1990961|drug transmembrane export;","GO:0005575|cellular_component;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0015297|antiporter activity;GO:0022857|transmembrane transporter activity;GO:0042910|xenobiotic transmembrane transporter activity;","K03327","TC.MATE, SLC47A, norM, mdtK, dinF; multidrug resistance protein, MATE family"]
["ENSRNOG00000062741",6,0.504811612,27,1.736921831,0.290635769,-1.782715827,1.740501E-3,1.290233E-3,"down","yes","Ldhal6b","protein_coding","chr1:45991991-45999272:-","gi|34328538|ref|NP_899163.1|",2021,0,"L-lactate dehydrogenase A-like 6B [Rattus norvegicus]","gi|34328537|ref|NM_183334.1|",1409,0,"Rattus norvegicus lactate dehydrogenase A-like 6B (Ldhal6b), mRNA","Q9BYZ2",598,0,"L-lactate dehydrogenase A-like 6B","CAC0267",266,{"v":6e-80,"d":"6.00E-80"},"COG0039","pfam00056","Ldh_1_N","lactate/malate dehydrogenase, NAD binding domain. L-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate. The enzyme participates in the citric acid cycle. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes. N-terminus (this family) is a Rossmann NAD-binding fold. C-terminus is an unusual alpha+beta fold.",".",".",".",".","."]
["ENSRNOG00000068017",20,1.682705373,56,3.602504538,0.4670932,-1.098217652,1.760579E-3,1.303874E-3,"down","yes","Fam78b","protein_coding","chr13:79162228-79250500:+","gi|63003925|ref|NP_780670.2|",1378,{"v":3E-175,"d":"3.00E-175"},"protein FAM78B [Mus musculus]","gi|237681182|ref|NM_001160261.1|",1971,0,"Mus musculus family with sequence similarity 78, member B (Fam78b), transcript variant 3, mRNA",".",".",".",".",".",".",".",".","pfam07290","DUF1449","Protein of unknown function (DUF1449). This family consists of several bacterial proteins of around 210 residues in length. The function of this family is unknown.",".",".",".",".","."]
["ENSRNOG00000006086",4,0.336541075,22,1.41526964,0.237792902,-2.072222444,1.779484E-3,0.001316442,"down","yes","Lynx1","protein_coding","chr7:106632797-106638023:-","gi|7106349|ref|NP_035968.1|",533,{"v":2e-59,"d":"2.00E-59"},"ly-6/neurotoxin-like protein 1 precursor [Mus musculus]","gi|298896202|emb|FQ212028.1|",3537,0,"Rattus norvegicus TL0AAA72YC21 mRNA sequence","P0DP60",209,{"v":6e-61,"d":"6.00E-61"},"Ly-6/neurotoxin-like protein 1",".",".",".",".","pfam00021","UPAR_LY6","u-PAR/Ly-6 domain. This extracellular disulphide bond rich domain is related to pfam00087.","GO:0007271|synaptic transmission, cholinergic;GO:0099601|regulation of neurotransmitter receptor activity;GO:2000272|negative regulation of signaling receptor activity;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0031225|anchored component of membrane;GO:0045202|synapse;","GO:0008200|ion channel inhibitor activity;GO:0030548|acetylcholine receptor regulator activity;GO:0030550|acetylcholine receptor inhibitor activity;GO:0033130|acetylcholine receptor binding;","K25369","LYNX1; Ly-6/neurotoxin-like protein 1"]
["ENSRNOG00000017546",4,0.336541075,22,1.41526964,0.237792902,-2.072222444,1.779484E-3,0.001316442,"down","yes","Mylk3","protein_coding","chr19:21691929-21742954:+","gi|408407655|sp|E9PT87.1|MYLK3_RAT",3720,0,"RecName: Full=Myosin light chain kinase 3; AltName: Full=Cardiac-MyBP-C-associated Ca/CaM kinase; Short=Cardiac-MLCK","gi|160961484|ref|NM_001110810.1|",2402,0,"Rattus norvegicus myosin light chain kinase 3 (Mylk3), mRNA","E9PT87",1437,0,"Myosin light chain kinase 3",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0002528|regulation of vascular permeability involved in acute inflammatory response;GO:0006468|protein phosphorylation;GO:0045214|sarcomere organization;GO:0048769|sarcomerogenesis;GO:0055003|cardiac myofibril assembly;GO:0060298|positive regulation of sarcomere organization;GO:0071347|cellular response to interleukin-1;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0015629|actin cytoskeleton;","GO:0004683|calmodulin-dependent protein kinase activity;GO:0004687|myosin light chain kinase activity;GO:0005524|ATP binding;","K00907","MYLK; myosin-light-chain kinase [EC:2.7.11.18]"]
["ENSRNOG00000025648",4,0.336541075,22,1.41526964,0.237792902,-2.072222444,1.779484E-3,0.001316442,"down","yes","Dhrs7l1","protein_coding","chr6:91289200-91312010:-","gi|61556948|ref|NP_001013116.1|",1559,0,"dehydrogenase/reductase (SDR family) member 7 [Rattus norvegicus]","gi|61556947|ref|NM_001013098.1|",1753,0,"Rattus norvegicus dehydrogenase/reductase (SDR family) member 7 (Dhrs7), mRNA","Q9Y394",372,{"v":2e-122,"d":"2.00E-122"},"Dehydrogenase/reductase SDR family member 7",".",".",".",".","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.",".",".","GO:0016491|oxidoreductase activity;",".","."]
["ENSRNOG00000003749",11,0.925487955,38,2.444556651,0.378591331,-1.40128672,0.001811746,1.338309E-3,"down","yes","ENSRNOG00000003749","protein_coding","chrX:13436418-13472830:-","gi|564398618|ref|XP_006256754.1|",2232,0,"PREDICTED: membrane transport protein XK isoform X1 [Rattus norvegicus]","gi|77748456|gb|BC107559.1|",3607,0,"Rattus norvegicus X-linked Kx blood group (McLeod syndrome) homolog, mRNA (cDNA clone MGC:124512 IMAGE:7933294), complete cds","Q5GH61",829,0,"Membrane transport protein XK",".",".",".",".","pfam09815","XK-related","XK-related protein. Members of this family comprise various XK-related proteins, that are involved in sodium-dependent transport of neutral amino acids or oligopeptides. These proteins are responsible for the Kx blood group system - defects results in McLeod syndrome, an X-linked multi-system disorder characterized by late onset abnormalities in the neuromuscular and hematopoietic systems.","GO:0006865|amino acid transport;GO:0006874|cellular calcium ion homeostasis;GO:0008150|biological_process;GO:0008361|regulation of cell size;GO:0010961|cellular magnesium ion homeostasis;GO:0031133|regulation of axon diameter;GO:0042552|myelination;GO:0048741|skeletal muscle fiber development;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;","K19522","XK; membrane transport protein XK"]
["ENSRNOG00000015353",11,0.925487955,38,2.444556651,0.378591331,-1.40128672,0.001811746,1.338309E-3,"down","yes","Prss12","protein_coding","chr2:211624134-211684126:+","gi|384950691|sp|G3V801.1|NETR_RAT",3740,0,"RecName: Full=Neurotrypsin; AltName: Full=Serine protease 12; Flags: Precursor","gi|26024220|ref|NM_053504.1|",2475,0,"Rattus norvegicus protease, serine 12 (Prss12), mRNA","G3V801",1445,0,"Neurotrypsin","mlr3307",94.4,{"v":5e-20,"d":"5.00E-20"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;GO:0006887|exocytosis;GO:0006897|endocytosis;GO:0031638|zymogen activation;","GO:0005886|plasma membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0031410|cytoplasmic vesicle;GO:0043083|synaptic cleft;GO:0043195|terminal bouton;GO:0045202|synapse;","GO:0004252|serine-type endopeptidase activity;GO:0005044|scavenger receptor activity;GO:0008233|peptidase activity;","K09624","PRSS12; neurotrypsin [EC:3.4.21.-]"]
["ENSRNOG00000053898",17,1.430299567,50,3.216521909,0.444672726,-1.169184174,1.882805E-3,0.001387224,"down","yes","AABR07013208.1","snoRNA","chr2:211685412-211685541:-","gi|149025889|gb|EDL82132.1|",189,{"v":7e-18,"d":"7.00E-18"},"rCG28667, isoform CRA_b [Rattus norvegicus]","gi|908662900|tpe|LN872364.1|",123,{"v":1E-56,"d":"1.00E-56"},"TPA: Mus musculus SNORA24 (ACA24) gene for small nucleolar RNA SNORA24 (ACA24)",".",".",".",".",".",".",".",".","pfam14724","mit_SMPDase","Mitochondrial-associated sphingomyelin phosphodiesterase. The GO annotation for this family indicates that it is a single-pass membrane protein, and it appears to be found in mitochondrial membranes. Sphingolipids play important roles in regulating cellular responses, and although mitochondria contain sphingolipids, direct regulation of their levels in mitochondria or mitochondria-associated membranes is mostly unclear. Sphingomyelin phosphodiesterases catalyse the hydrolysis of sphingomyelin to ceramide and phosphocholine, and these metabolites are involved in signalling pathways.",".",".",".",".","."]
["ENSRNOG00000007804",13,1.093758492,42,2.701878404,0.404814107,-1.30466853,0.001902928,1.401102E-3,"down","yes","C1galt1","protein_coding","chr4:35928104-35961831:+","gi|672048916|ref|XP_008760947.1|",2135,0,"PREDICTED: glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 isoform X1 [Rattus norvegicus]","gi|672048917|ref|XM_006236091.2|",1495,0,"PREDICTED: Rattus norvegicus core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1 (C1galt1), transcript variant X2, mRNA","Q9JJ05",767,0,"Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1",".",".",".",".","pfam02434","Fringe","Fringe-like. The drosophila protein fringe (FNG) is a glucosaminyltransferase that controls the response of the Notch receptor to specific ligands. FNG is localized to the Golgi apparatus (not secreted as previously thought). Modification of Notch occurs through glycosylation by FNG. The xenopus homologue, lunatic fringe, has been implicated in a variety of functions.","GO:0001525|angiogenesis;GO:0001822|kidney development;GO:0006493|protein O-linked glycosylation;GO:0016266|O-glycan processing;GO:0016267|O-glycan processing, core 1;GO:0060576|intestinal epithelial cell development;","GO:0016021|integral component of membrane;","GO:0016263|glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity;GO:0046872|metal ion binding;","K00731","C1GALT1; glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase [EC:2.4.1.122]"]
["ENSRNOG00000046949",13,1.093758492,42,2.701878404,0.404814107,-1.30466853,0.001902928,1.401102E-3,"down","yes","Kcnb1","protein_coding","chr3:155822963-155916194:-","gi|24418849|sp|P15387.3|KCNB1_RAT",4291,0,"RecName: Full=Potassium voltage-gated channel subfamily B member 1; AltName: Full=Delayed rectifier potassium channel 1; Short=DRK1; AltName: Full=Voltage-gated potassium channel subunit Kv2.1","gi|6981119|ref|NM_013186.1|",3317,0,"Rattus norvegicus potassium voltage-gated channel subfamily B member 1 (Kcnb1), mRNA","P15387",1657,0,"Potassium voltage-gated channel subfamily B member 1","PA1496",100,{"v":3e-21,"d":"3.00E-21"},"COG1226","pfam03521","Kv2channel","Kv2 voltage-gated K+ channel.","GO:0001508|action potential;GO:0006813|potassium ion transport;GO:0006887|exocytosis;GO:0006904|vesicle docking involved in exocytosis;GO:0007215|glutamate receptor signaling pathway;GO:0010701|positive regulation of norepinephrine secretion;GO:0031669|cellular response to nutrient levels;GO:0033605|positive regulation of catecholamine secretion;GO:0034765|regulation of ion transmembrane transport;GO:0042593|glucose homeostasis;GO:0045956|positive regulation of calcium ion-dependent exocytosis;GO:0046676|negative regulation of insulin secretion;GO:0051260|protein homooligomerization;GO:0071333|cellular response to glucose stimulus;GO:0071805|potassium ion transmembrane transport;GO:0072659|protein localization to plasma membrane;GO:0090314|positive regulation of protein targeting to membrane;GO:0097623|potassium ion export across plasma membrane;GO:0098900|regulation of action potential;GO:1900454|positive regulation of long-term synaptic depression;GO:2000671|regulation of motor neuron apoptotic process;","GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0008076|voltage-gated potassium channel complex;GO:0009986|cell surface;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016328|lateral plasma membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0032590|dendrite membrane;GO:0032809|neuronal cell body membrane;GO:0042383|sarcolemma;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0045211|postsynaptic membrane;","GO:0000149|SNARE binding;GO:0005249|voltage-gated potassium channel activity;GO:0005251|delayed rectifier potassium channel activity;GO:0005515|protein binding;GO:0015271|outward rectifier potassium channel activity;GO:0044325|ion channel binding;GO:0046982|protein heterodimerization activity;GO:0047485|protein N-terminus binding;","K04885","KCNB1, KV2.1; potassium voltage-gated channel Shab-related subfamily B member 1"]
["ENSRNOG00000055049",14,1.177893761,44,2.83053928,0.416137578,-1.264867522,1.919458E-3,0.001412509,"down","yes","Aldh1a2","protein_coding","chr8:71877850-71957107:+","gi|225735575|ref|NP_446348.2|",2765,0,"retinal dehydrogenase 2 [Rattus norvegicus]","gi|225735574|ref|NM_053896.2|",2244,0,"Rattus norvegicus aldehyde dehydrogenase 1 family, member A2 (Aldh1a2), mRNA","Q63639",1069,0,"Retinal dehydrogenase 2","SPAC9E9.09c",551,0,"COG1012","pfam00171","Aldedh","Aldehyde dehydrogenase family. This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:1.2.1.3. Succinate-semialdehyde dehydrogenase EC:1.2.1.16. Lactaldehyde dehydrogenase EC:1.2.1.22. Benzaldehyde dehydrogenase EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase EC: 1.5.1.12. Acetaldehyde dehydrogenase EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase EC:1.2.1.41. This family also includes omega crystallin, an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.","GO:0001568|blood vessel development;GO:0001822|kidney development;GO:0001889|liver development;GO:0001936|regulation of endothelial cell proliferation;GO:0002138|retinoic acid biosynthetic process;GO:0003007|heart morphogenesis;GO:0007494|midgut development;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0009855|determination of bilateral symmetry;GO:0009952|anterior/posterior pattern specification;GO:0009954|proximal/distal pattern formation;GO:0010628|positive regulation of gene expression;GO:0014032|neural crest cell development;GO:0016331|morphogenesis of embryonic epithelium;GO:0021915|neural tube development;GO:0021983|pituitary gland development;GO:0030182|neuron differentiation;GO:0030324|lung development;GO:0030326|embryonic limb morphogenesis;GO:0030900|forebrain development;GO:0030902|hindbrain development;GO:0031016|pancreas development;GO:0031076|embryonic camera-type eye development;GO:0032355|response to estradiol;GO:0033189|response to vitamin A;GO:0034097|response to cytokine;GO:0035115|embryonic forelimb morphogenesis;GO:0035799|ureter maturation;GO:0042572|retinol metabolic process;GO:0042573|retinoic acid metabolic process;GO:0042574|retinal metabolic process;GO:0042904|9-cis-retinoic acid biosynthetic process;GO:0043010|camera-type eye development;GO:0043065|positive regulation of apoptotic process;GO:0048384|retinoic acid receptor signaling pathway;GO:0048566|embryonic digestive tract development;GO:0048738|cardiac muscle tissue development;GO:0051289|protein homotetramerization;GO:0060324|face development;GO:0071300|cellular response to retinoic acid;GO:0090242|retinoic acid receptor signaling pathway involved in somitogenesis;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0048471|perinuclear region of cytoplasm;","GO:0001758|retinal dehydrogenase activity;GO:0004028|3-chloroallyl aldehyde dehydrogenase activity;GO:0004029|aldehyde dehydrogenase (NAD) activity;GO:0016918|retinal binding;","K07249","ALDH1A; retinal dehydrogenase [EC:1.2.1.36]"]
["ENSRNOG00000012750",1,0.084135269,13,0.836295696,0.100604689,-3.313230543,1.952255E-3,1.435286E-3,"down","yes","Pabpc1l","protein_coding","chr3:152693700-152725997:+","gi|392346932|ref|XP_230831.6|",3125,0,"PREDICTED: polyadenylate-binding protein 1-like isoform X2 [Rattus norvegicus]","gi|672048257|ref|XM_230831.8|",1830,0,"PREDICTED: Rattus norvegicus poly(A) binding protein, cytoplasmic 1-like (Pabpc1l), transcript variant X2, mRNA","Q4VXU2",908,0,"Polyadenylate-binding protein 1-like",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0001556|oocyte maturation;GO:0006338|chromatin remodeling;GO:0006378|mRNA polyadenylation;GO:0048096|chromatin-mediated maintenance of transcription;GO:0051647|nucleus localization;","GO:0005634|nucleus;GO:0005829|cytosol;GO:0010494|cytoplasmic stress granule;GO:1990904|ribonucleoprotein complex;","GO:0003723|RNA binding;GO:0003730|mRNA 3'-UTR binding;GO:0008143|poly(A) binding;GO:0008266|poly(U) RNA binding;","K13126","PABPC; polyadenylate-binding protein"]
["ENSRNOG00000012821",1,0.084135269,13,0.836295696,0.100604689,-3.313230543,1.952255E-3,1.435286E-3,"down","yes","Cnmd","protein_coding","chr15:55041561-55066297:-","gi|117558828|gb|AAI27494.1|",1786,0,"Leukocyte cell derived chemotaxin 1 [Rattus norvegicus]","gi|13540670|ref|NM_030854.1|",1361,0,"Rattus norvegicus leukocyte cell derived chemotaxin 1 (Lect1), mRNA","O70367",691,0,"Leukocyte cell-derived chemotaxin 1",".",".",".",".","pfam04089","BRICHOS","BRICHOS domain. The BRICHOS domain is about 100 amino acids long. It is found in a variety of proteins implicated in dementia, respiratory distress and cancer. Its exact function is unknown; roles that have been proposed for it include (a) in targeting of the protein to the secretory pathway, (b) intramolecular chaperone-like function, and (c) assisting the specialized intracellular protease processing system. This C-terminal domain is embedded in the endoplasmic reticulum lumen, and binds to the N-terminal, transmembrane, SP_C, pfam08999, provided that it is in non-helical conformation. Thus the Brichos domain of proSP-C is a chaperone that induces alpha-helix formation of an aggregation-prone TM region.","GO:0001886|endothelial cell morphogenesis;GO:0001937|negative regulation of endothelial cell proliferation;GO:0016525|negative regulation of angiogenesis;GO:0030948|negative regulation of vascular endothelial growth factor receptor signaling pathway;GO:0051216|cartilage development;","GO:0005576|extracellular region;GO:0012505|endomembrane system;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000018790",1,0.084135269,13,0.836295696,0.100604689,-3.313230543,1.952255E-3,1.435286E-3,"down","yes","Kcnh4","protein_coding","chr10:85668337-85688158:-","gi|149054246|gb|EDM06063.1|",4683,0,"potassium voltage-gated channel, subfamily H (eag-related), member 4 [Rattus norvegicus]","gi|16758435|ref|NM_053630.1|",3712,0,"Rattus norvegicus potassium voltage-gated channel subfamily H member 4 (Kcnh4), mRNA","Q9R1T9",1808,0,"Potassium voltage-gated channel subfamily H member 4","CC0285_1",92.8,{"v":2E-19,"d":"2.00E-19"},"COG2202","pfam13426","PAS_9","PAS domain.","GO:0034765|regulation of ion transmembrane transport;GO:0042391|regulation of membrane potential;GO:0071805|potassium ion transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;","GO:0005249|voltage-gated potassium channel activity;","K04907","KCNH4, KV12.3; potassium voltage-gated channel Eag-related subfamily H member 4"]
["ENSRNOG00000019058",1,0.084135269,13,0.836295696,0.100604689,-3.313230543,1.952255E-3,1.435286E-3,"down","yes","Gstm3l","protein_coding","chr2:195607289-195612475:-","gi|149025659|gb|EDL81902.1|",1174,{"v":2E-159,"d":"2.00E-159"},"rCG28672, isoform CRA_a [Rattus norvegicus]","gi|324711004|ref|NM_010359.2|",692,0,"Mus musculus glutathione S-transferase, mu 3 (Gstm3), mRNA","P19639",435,{"v":1e-152,"d":"1.00E-152"},"Glutathione S-transferase Mu 3",".",".",".",".","pfam00043","GST_C","Glutathione S-transferase, C-terminal domain. GST conjugates reduced glutathione to a variety of targets including S-crystallin from squid, the eukaryotic elongation factor 1-gamma, the HSP26 family of stress-related proteins and auxin-regulated proteins in plants. Stringent starvation proteins in Escherichia coli are also included in the alignment but are not known to have GST activity.     The glutathione molecule binds in a cleft between N and C-terminal domains. The catalytically important residues are proposed to reside in the N-terminal domain. In plants, GSTs are encoded by a large gene family (48 GST genes in Arabidopsis) and can be divided into the phi, tau, theta, zeta, and lambda classes.","GO:0006749|glutathione metabolic process;","GO:0005829|cytosol;GO:0045171|intercellular bridge;","GO:0004364|glutathione transferase activity;GO:0042802|identical protein binding;","K00799","GST, gst; glutathione S-transferase [EC:2.5.1.18]"]
["ENSRNOG00000054529",1,0.084135269,13,0.836295696,0.100604689,-3.313230543,1.952255E-3,1.435286E-3,"down","yes","Gm25395","scaRNA","chr9:88442065-88442334:+",".",".",".",".","gi|354789701|gb|JN954202.1|",223,{"v":8e-112,"d":"8.00E-112"},"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Atg16l1:tm1a(EUCOMM)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam06517","Orthopox_A43R","Orthopoxvirus A43R protein. This family consists of several Orthopoxvirus A43R proteins. The function of this family is unknown.",".",".",".",".","."]
["ENSRNOG00000015259",7,0.588946881,29,1.865582707,0.315690577,-1.663416898,0.001993104,0.001462553,"down","yes","Pth2r","protein_coding","chr9:66706050-66810036:+","gi|149045964|gb|EDL98857.1|",2790,0,"parathyroid hormone receptor 2, isoform CRA_a [Rattus norvegicus]","gi|451958082|ref|NM_031089.2|",1960,0,"Rattus norvegicus parathyroid hormone 2 receptor (Pth2r), mRNA","P70555",1069,0,"Parathyroid hormone 2 receptor",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0007166|cell surface receptor signaling pathway;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007188|adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0120162|positive regulation of cold-induced thermogenesis;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004991|parathyroid hormone receptor activity;GO:0008528|G protein-coupled peptide receptor activity;GO:0017046|peptide hormone binding;","K04586","PTHR2; parathyroid hormone receptor 2"]
["ENSRNOG00000018851",7,0.588946881,29,1.865582707,0.315690577,-1.663416898,0.001993104,0.001462553,"down","yes","Ppp2r2b","protein_coding","chr18:34653721-35081025:-","gi|76880455|ref|NP_071545.2|",2349,0,"serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [Rattus norvegicus]","gi|440918726|ref|NM_022209.3|",1982,0,"Rattus norvegicus protein phosphatase 2, regulatory subunit B, beta (Ppp2r2b), transcript variant 1, mRNA","P36877",856,0,"Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform","SPAC227.07c",464,{"v":2e-154,"d":"2.00E-154"},"COG5170","pfam06578","YscK","YOP proteins translocation protein K (YscK). This family consists of several YscK proteins. The function of this protein is unknown but it belongs to an operon involved in the secretion of Yop proteins across bacterial membranes.","GO:0000266|mitochondrial fission;GO:0006626|protein targeting to mitochondrion;GO:0007286|spermatid development;GO:0007420|brain development;GO:0030182|neuron differentiation;GO:0043525|positive regulation of neuron apoptotic process;GO:0043653|mitochondrial fragmentation involved in apoptotic process;GO:0043666|regulation of phosphoprotein phosphatase activity;GO:0050790|regulation of catalytic activity;GO:0070262|peptidyl-serine dephosphorylation;","GO:0000159|protein phosphatase type 2A complex;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0016020|membrane;","GO:0005515|protein binding;GO:0019888|protein phosphatase regulator activity;GO:0044877|protein-containing complex binding;","K04354","PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B"]
["ENSRNOG00000038819",7,0.588946881,29,1.865582707,0.315690577,-1.663416898,0.001993104,0.001462553,"down","yes","RGD1564308","protein_coding","chr16:46291311-46315625:+","gi|293342450|ref|XP_001061230.2|",1655,0,"PREDICTED: UPF0602 protein C4orf47 homolog [Rattus norvegicus]","gi|672029386|ref|XM_006222240.2|",1172,0,"PREDICTED: Rattus norvegicus similar to LOC495042 protein (RGD1564308), transcript variant X3, mRNA","Q3U1D9",595,0,"UPF0602 protein C4orf47 homolog",".",".",".",".","pfam15239","DUF4586","Domain of unknown function (DUF4586). This protein family, refers to a domain of unknown function. The precise role of this protein domain remains to be elucidated. This family of proteins is found in eukaryotes and are typically between 256 and 320 amino acids in length. There is a single completely conserved residue, phenylalanine (F), that may be functionally important. In humans, the protein is found in the position, chromosome 4 open reading frame 47.",".","GO:0005813|centrosome;GO:0005881|cytoplasmic microtubule;GO:0097731|9+0 non-motile cilium;",".",".","."]
["ENSRNOG00000011696",24,2.019246448,63,4.052817606,0.498232747,-1.005108248,0.002030367,1.487925E-3,"down","yes","Lifr","protein_coding","chr2:56250120-56286699:+","gi|564335498|ref|XP_006232089.1|",5476,0,"PREDICTED: leukemia inhibitory factor receptor isoform X1 [Rattus norvegicus]","gi|672041633|ref|XM_008760796.1|",3341,0,"PREDICTED: Rattus norvegicus leukemia inhibitory factor receptor alpha (Lifr), transcript variant X2, mRNA","O70535",2109,0,"Leukemia inhibitory factor receptor",".",".",".",".","pfam00041","fn3","Fibronectin type III domain.","GO:0008284|positive regulation of cell proliferation;GO:0010656|negative regulation of muscle cell apoptotic process;GO:0014070|response to organic cyclic compound;GO:0019221|cytokine-mediated signaling pathway;GO:0031100|animal organ regeneration;GO:0034097|response to cytokine;GO:0038165|oncostatin-M-mediated signaling pathway;GO:0048812|neuron projection morphogenesis;GO:0048861|leukemia inhibitory factor signaling pathway;GO:0070120|ciliary neurotrophic factor-mediated signaling pathway;","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0043235|receptor complex;","GO:0004896|cytokine receptor activity;GO:0004897|ciliary neurotrophic factor receptor activity;GO:0004923|leukemia inhibitory factor receptor activity;GO:0004924|oncostatin-M receptor activity;GO:0005127|ciliary neurotrophic factor receptor binding;GO:0019838|growth factor binding;GO:0019955|cytokine binding;","K05058","LIFR, CD118; leukemia inhibitory factor receptor"]
["ENSRNOG00000038135",3,0.252405806,19,1.222278326,0.206504362,-2.275755838,0.002079701,1.519954E-3,"down","yes","RatNP-3b","protein_coding","chr16:70513888-70546522:-","gi|2494047|sp|Q62713.1|DEF3A_RAT",370,{"v":1E-42,"d":"1.00E-42"},"RecName: Full=Neutrophil antibiotic peptide NP-3A; Short=RatNP-3a; AltName: Full=Neutrophil defensin 3; Flags: Precursor","gi|1041804|gb|U16683.1|RNU16683",471,0,"Rattus norvegicus defensin RatNP-3 precursor mRNA, complete cds","Q62713",147,{"v":4e-44,"d":"4.00E-44"},"Neutrophil antibiotic peptide NP-3A",".",".",".",".","pfam00323","Defensin_1","Mammalian defensin.","GO:0031640|killing of cells of other organism;GO:0050832|defense response to fungus;",".",".","K05230","DEFA; defensin, alpha"]
["ENSRNOG00000051867",3,0.252405806,19,1.222278326,0.206504362,-2.275755838,0.002079701,1.519954E-3,"down","yes","Zfp758","protein_coding","chr1:61942116-61989490:-","gi|564296578|ref|XP_006223031.1|",3394,0,"PREDICTED: zinc finger protein 260-like [Rattus norvegicus]","gi|672070789|ref|XM_006228088.2|",2384,0,"PREDICTED: Rattus norvegicus zinc finger protein 758 (Zfp758), mRNA","A2VDQ7",596,0,"Zinc finger protein 420",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0016604|nuclear body;","GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0043565|sequence-specific DNA binding;GO:0046872|metal ion binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSRNOG00000058308",3,0.252405806,19,1.222278326,0.206504362,-2.275755838,0.002079701,1.519954E-3,"down","yes","Asic2","protein_coding","chr10:65870594-66940424:-","gi|77404415|ref|NP_001029186.1|",2566,0,"acid-sensing ion channel 2 isoform MDEG1 [Rattus norvegicus]","gi|77404414|ref|NM_001034014.1|",2389,0,"Rattus norvegicus acid sensing ion channel subunit 2 (Asic2), transcript variant MDEG1, mRNA","Q62962",993,0,"Acid-sensing ion channel 2",".",".",".",".","pfam00858","ASC","Amiloride-sensitive sodium channel.","GO:0003026|regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback;GO:0006812|cation transport;GO:0006814|sodium ion transport;GO:0007602|phototransduction;GO:0007605|sensory perception of sound;GO:0009612|response to mechanical stimulus;GO:0010447|response to acidic pH;GO:0019229|regulation of vasoconstriction;GO:0034220|ion transmembrane transport;GO:0034765|regulation of ion transmembrane transport;GO:0035418|protein localization to synapse;GO:0035725|sodium ion transmembrane transport;GO:0042391|regulation of membrane potential;GO:0043066|negative regulation of apoptotic process;GO:0050915|sensory perception of sour taste;GO:0050974|detection of mechanical stimulus involved in sensory perception;GO:0051965|positive regulation of synapse assembly;GO:0071466|cellular response to xenobiotic stimulus;GO:0071468|cellular response to acidic pH;GO:2001259|positive regulation of cation channel activity;","GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043197|dendritic spine;GO:0045202|synapse;","GO:0005216|ion channel activity;GO:0005248|voltage-gated sodium channel activity;GO:0005261|cation channel activity;GO:0005515|protein binding;GO:0015280|ligand-gated sodium channel activity;GO:0022839|ion gated channel activity;","K04828","ASIC2, ACCN1, BNAC1; acid-sensing ion channel 2"]
["ENSRNOG00000066392",3,0.252405806,19,1.222278326,0.206504362,-2.275755838,0.002079701,1.519954E-3,"down","yes","ENSRNOG00000066392","lncRNA","chr4:62593370-62597292:+",".",".",".",".","gi|62988373|gb|AC153817.6|",663,0,"Mus musculus BAC RP23-11P24 (Roswell Park Cancer Institute (C57BL/6J Female) Mouse BAC Library) complete sequence",".",".",".",".",".",".",".",".","pfam03849","Tfb2","Transcription factor Tfb2.",".",".",".",".","."]
["ENSRNOG00000029342",23,1.935111179,61,3.924156729,0.493127903,-1.019966207,0.002116768,1.545177E-3,"down","yes","Scn7a","protein_coding","chr3:51335841-51438256:-","gi|564341195|ref|XP_006234358.1|",8480,0,"PREDICTED: sodium channel protein type 7 subunit alpha isoform X1 [Rattus norvegicus]","gi|672045864|ref|XM_006234296.2|",6630,0,"PREDICTED: Rattus norvegicus sodium channel, voltage-gated, type VII, alpha subunit (Scn7a), transcript variant X1, mRNA","Q01118",2394,0,"Sodium channel protein type 7 subunit alpha",".",".",".",".","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0006814|sodium ion transport;GO:0006936|muscle contraction;GO:0009617|response to bacterium;GO:0019228|neuronal action potential;GO:0034765|regulation of ion transmembrane transport;GO:0035725|sodium ion transmembrane transport;GO:0055078|sodium ion homeostasis;GO:0086010|membrane depolarization during action potential;","GO:0001518|voltage-gated sodium channel complex;GO:0005886|plasma membrane;GO:0030424|axon;GO:0097386|glial cell projection;","GO:0005244|voltage-gated ion channel activity;GO:0005248|voltage-gated sodium channel activity;GO:0005272|sodium channel activity;","K04839","SCN7A, SCN6A; voltage-gated sodium channel type VII alpha"]
["ENSRNOG00000003704",0,0.042067634,11,0.70763482,0.059448225,-4.072222444,0.002138374,0.001559694,"down","yes","Fam184b","protein_coding","chr14:65475489-65591388:+","gi|761631386|ref|NP_001292100.1|",4600,0,"uncharacterized protein LOC289671 [Rattus norvegicus]","gi|761631385|ref|NM_001305171.1|",4988,0,"Rattus norvegicus family with sequence similarity 184, member B (Fam184b), mRNA",".",".",".",".",".",".",".",".","pfam10174","Cast","RIM-binding protein of the cytomatrix active zone. This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.",".",".",".",".","."]
["ENSRNOG00000012344",0,0.042067634,11,0.70763482,0.059448225,-4.072222444,0.002138374,0.001559694,"down","yes","Slc7a9","protein_coding","chr1:88110644-88132641:+","gi|16758812|ref|NP_446381.1|",2130,0,"B(0,+)-type amino acid transporter 1 [Rattus norvegicus]","gi|672035581|ref|XM_006228877.2|",1599,0,"PREDICTED: Rattus norvegicus solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 (Slc7a9), transcript variant X5, mRNA","P82252",825,0,"b(0,+)-type amino acid transporter 1","BS_ykbA",117,{"v":1E-27,"d":"1.00E-27"},"COG0531","pfam13520","AA_permease_2","Amino acid permease.","GO:0003333|amino acid transmembrane transport;GO:0006865|amino acid transport;GO:0015804|neutral amino acid transport;GO:0015811|L-cystine transport;GO:1902475|L-alpha-amino acid transmembrane transport;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0031526|brush border membrane;","GO:0015171|amino acid transmembrane transporter activity;GO:0015175|neutral amino acid transmembrane transporter activity;GO:0015179|L-amino acid transmembrane transporter activity;GO:0015184|L-cystine transmembrane transporter activity;GO:0042605|peptide antigen binding;","K13868","SLC7A9_15, BAT1; solute carrier family 7 (L-type amino acid transporter), member 9/15"]
["ENSRNOG00000013085",0,0.042067634,11,0.70763482,0.059448225,-4.072222444,0.002138374,0.001559694,"down","yes","Nkain3","protein_coding","chr5:33623713-34309381:-","gi|157817666|ref|NP_001103010.1|",956,{"v":4E-125,"d":"4.00E-125"},"sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3 precursor [Rattus norvegicus]","gi|157817665|ref|NM_001109540.1|",1428,0,"Rattus norvegicus Na+/K+ transporting ATPase interacting 3 (Nkain3), mRNA","Q3URJ8",369,{"v":2E-125,"d":"2.00E-125"},"Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3",".",".",".",".","pfam05640","NKAIN","Na,K-Atpase Interacting protein. NKAIN (Na,K-Atpase INteracting) proteins are a family of evolutionary conserved transmembrane proteins that localize to neurons, that are critical for neuronal function, and that interact with the beta subunits, beta1 in vertebrates and beta in Drosophila, of Na,K-ATPase. NKAINs have highly conserved trans-membrane domains but otherwise no other characterized domains. NKAINs may function as subunits of pore or channel structures in neurons or they may affect the function of other membrane proteins. They are likely to function within the membrane bilayer.","GO:0002028|regulation of sodium ion transport;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;",".","K22735","NKAIN; sodium/potassium-transporting ATPase subunit beta-1-interacting protein"]
["ENSRNOG00000057750",0,0.042067634,11,0.70763482,0.059448225,-4.072222444,0.002138374,0.001559694,"down","yes","AABR07018058.1","protein_coding","chr15:31592001-31592384:-","gi|731501926|ref|XP_003417074.2|",638,{"v":6e-83,"d":"6.00E-83"},"PREDICTED: nuclear transport factor 2 isoform X1 [Loxodonta africana]","gi|672084785|ref|XM_006255480.2|",336,{"v":2E-174,"d":"2.00E-174"},"PREDICTED: Rattus norvegicus nuclear transport factor 2 (Nutf2), transcript variant X1, mRNA","P61972",249,{"v":3e-84,"d":"3.00E-84"},"Nuclear transport factor 2",".",".",".",".","pfam02136","NTF2","Nuclear transport factor 2 (NTF2) domain. This family includes the NTF2-like Delta-5-3-ketosteroid isomerase proteins.",".",".",".",".","."]
["ENSRNOG00000066567",8,0.673082149,31,1.994243584,0.337512506,-1.566987136,0.002202091,1.601978E-3,"down","yes","ENSRNOG00000066567","lncRNA","chr1:202065529-202074812:-","gi|531997376|ref|XP_005343247.1|",217,{"v":2e-25,"d":"2.00E-25"},"PREDICTED: proteasome subunit alpha type-3 [Microtus ochrogaster]","gi|229220813|gb|AC126581.3|",6601,0,"Rattus norvegicus CH230-12O23 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","O70435",89.4,{"v":2e-17,"d":"2.00E-17"},"Proteasome subunit alpha type-3",".",".",".",".","pfam00227","Proteasome","Proteasome subunit. The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria. The second is call beta-proteobacteria proteasome homologue (BPH).",".",".",".",".","."]
["ENSRNOG00000047413",2,0.168270537,16,1.029287011,0.16348262,-2.612790825,0.002216981,1.612493E-3,"down","yes","Cby2","protein_coding","chr15:50909436-50934633:-","gi|672078782|ref|XP_008769115.1|",1947,0,"PREDICTED: spermatid-associated protein isoform X1 [Rattus norvegicus]","gi|672078781|ref|XM_008770893.1|",2110,0,"PREDICTED: Rattus norvegicus spermatid associated (Spert), transcript variant X1, mRNA","Q6AXV6",733,0,"Spermatid-associated protein",".",".",".",".","pfam14645","Chibby","Chibby family. This family includes the eukaryotic chibby proteins. These proteins inhibit the wingless/Wnt pathway by binding to beta-catenin and inhibiting beta-catenin-mediated transcriptional activation. Chibby is Japanese for small, and is named after the RNAi phenotype seen in Drosophila.",".","GO:0031410|cytoplasmic vesicle;","GO:0042802|identical protein binding;","K23403","SPERT, CBY2; spermatid-associated protein"]
["ENSRNOG00000020434",5,0.420676343,24,1.543930516,0.272471033,-1.875825231,0.002238147,0.001626367,"down","yes","Ascl2","protein_coding","chr1:198148999-198151406:-","gi|13928686|ref|NP_113691.1|",1044,{"v":1E-136,"d":"1.00E-136"},"achaete-scute homolog 2 [Rattus norvegicus]","gi|635172859|ref|NM_031503.2|",1572,0,"Rattus norvegicus achaete-scute family bHLH transcription factor 2 (Ascl2), mRNA","P19360",406,{"v":5e-138,"d":"5.00E-138"},"Achaete-scute homolog 2",".",".",".",".","pfam00010","HLH","Helix-loop-helix DNA-binding domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001666|response to hypoxia;GO:0001701|in utero embryonic development;GO:0001890|placenta development;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007423|sensory organ development;GO:0010626|negative regulation of Schwann cell proliferation;GO:0030154|cell differentiation;GO:0030182|neuron differentiation;GO:0035019|somatic stem cell population maintenance;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050767|regulation of neurogenesis;GO:0060708|spongiotrophoblast differentiation;GO:0060712|spongiotrophoblast layer development;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0090575|RNA polymerase II transcription factor complex;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0043565|sequence-specific DNA binding;GO:0046983|protein dimerization activity;GO:0070888|E-box binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09067","ASCL; achaete-scute complex protein"]
["ENSRNOG00000052770",5,0.420676343,24,1.543930516,0.272471033,-1.875825231,0.002238147,0.001626367,"down","yes","U6","snRNA","chr6:14995891-14995987:-",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","pfam02460","Patched","Patched family. The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.",".",".",".",".","."]
["ENSRNOG00000059160",5,0.420676343,24,1.543930516,0.272471033,-1.875825231,0.002238147,0.001626367,"down","yes","ENSRNOG00000059160","protein_coding","chr5:157422422-157447336:-","gi|564306408|ref|XP_006225660.1|",2523,0,"PREDICTED: zinc finger protein 664-like isoform X2 [Rattus norvegicus]","gi|672020088|ref|XM_006225598.2|",1789,0,"PREDICTED: Rattus norvegicus zinc finger protein 624-like (LOC102551014), transcript variant X3, mRNA","P0CJ79",394,{"v":2E-125,"d":"2.00E-125"},"Zinc finger protein 888",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006357|regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0046872|metal ion binding;",".","."]
["ENSRNOG00000070692",17,1.430299567,49,3.152191471,0.45374768,-1.140037828,0.002566644,1.844395E-3,"down","yes","ENSRNOG00000070692","protein_coding","chr15:4782866-4790453:+","gi|564385445|ref|XP_006251744.1|",666,{"v":1E-78,"d":"1.00E-78"},"PREDICTED: uncharacterized protein LOC102547093 isoform X2 [Rattus norvegicus]","gi|672077354|ref|XR_595997.1|",795,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103693798 (LOC103693798), ncRNA",".",".",".",".",".",".",".",".","pfam04822","Takusan","Takusan. This domain is named takusan, which is a Japanese word meaning 'many'. Members of this family regulate synaptic activity.",".",".",".",".","."]
["ENSRNOG00000020242",12,1.009623224,39,2.508887089,0.402418757,-1.313230543,2.63664E-3,1.891567E-3,"down","yes","Art5","protein_coding","chr1:156473362-156483324:-","gi|564330007|ref|XP_006229905.1|",1639,0,"PREDICTED: ecto-ADP-ribosyltransferase 5 isoform X1 [Rattus norvegicus]","gi|61556766|ref|NM_001013039.1|",1981,0,"Rattus norvegicus ADP-ribosyltransferase 5 (Art5), mRNA","Q5XHY4",629,0,"Ecto-ADP-ribosyltransferase 5",".",".",".",".","pfam01129","ART","NAD:arginine ADP-ribosyltransferase.","GO:0006471|protein ADP-ribosylation;GO:0018120|peptidyl-arginine ADP-ribosylation;","GO:0005576|extracellular region;GO:0016020|membrane;","GO:0003950|NAD+ ADP-ribosyltransferase activity;GO:0003953|NAD+ nucleosidase activity;","K19977","ART5; ADP-ribosyltransferase 5 [EC:2.4.2.31]"]
["ENSRNOG00000061237",6,0.504811612,26,1.672591393,0.301814068,-1.728268043,0.002637261,1.891567E-3,"down","yes","Dio1","protein_coding","chr5:122074279-122090970:-","gi|2654263|emb|CAA41063.1|",1305,{"v":2e-173,"d":"2.00E-173"},"thyroxine deiodinase [Rattus norvegicus]","gi|57330|emb|X57999.1|",2051,0,"Rattus norvegicus mRNA for type I thyroxine deiodinase","P24389",507,{"v":5E-175,"d":"5.00E-175"},"Type I iodothyronine deiodinase",".",".",".",".","pfam00837","T4_deiodinase","Iodothyronine deiodinase. Iodothyronine deiodinase converts thyroxine (T4) to 3,5,3'-triiodothyronine (T3).","GO:0006091|generation of precursor metabolites and energy;GO:0006520|cellular amino acid metabolic process;GO:0042403|thyroid hormone metabolic process;GO:0042446|hormone biosynthetic process;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0004800|thyroxine 5'-deiodinase activity;GO:0008430|selenium binding;","K01562","DIO1; type I thyroxine 5'-deiodinase [EC:1.21.99.4]"]
["ENSRNOG00000019050",13,1.093758492,41,2.637547966,0.414687621,-1.269903112,0.002663783,1.909914E-3,"down","yes","ENSRNOG00000019050","protein_coding","chr1:232127170-232154435:+","gi|9910234|ref|NP_064481.1|",2382,0,"interferon-induced protein with tetratricopeptide repeats 1-like protein [Rattus norvegicus]","gi|9910233|ref|NM_020096.1|",1926,0,"Rattus norvegicus interferon-induced protein with tetratricopeptide repeats 1 (Ifit1), mRNA","Q64282",790,0,"Interferon-induced protein with tetratricopeptide repeats 1",".",".",".",".","pfam13414","TPR_11","TPR repeat.","GO:0009615|response to virus;GO:0009617|response to bacterium;GO:0035457|cellular response to interferon-alpha;GO:0035458|cellular response to interferon-beta;GO:0051607|defense response to virus;","GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0003723|RNA binding;","K14217","IFIT1; interferon-induced protein with tetratricopeptide repeats 1"]
["ENSRNOG00000065198",14,1.177893761,43,2.766208842,0.425815196,-1.231700658,0.002666695,0.001911751,"down","yes","ENSRNOG00000065198","lncRNA","chr7:62800401-62804991:-",".",".",".",".","gi|54697291|gb|AC134329.3|",178,{"v":5e-86,"d":"5.00E-86"},"Mus musculus BAC clone RP24-310D17 from 10, complete sequence",".",".",".",".",".",".",".",".","pfam01683","EB","EB module. This domain has no known function. It is found in several C. elegans proteins. The domain contains 8 conserved cysteines that probably form four disulphide bridges. This domain is found associated with kunitz domains pfam00014.",".",".",".",".","."]
["ENSRNOG00000012566",4,0.336541075,21,1.350939202,0.249116373,-2.005108248,0.002802595,0.001999698,"down","yes","Kcnv2","protein_coding","chr1:224999552-225014062:+","gi|157822321|ref|NP_001099840.1|",2749,0,"potassium voltage-gated channel subfamily V member 2 [Rattus norvegicus]","gi|157822320|ref|NM_001106370.1|",5195,0,"Rattus norvegicus potassium voltage-gated channel modifier subfamily V member 2 (Kcnv2), mRNA","Q8CFS6",996,0,"Potassium voltage-gated channel subfamily V member 2","DR0830",80.1,{"v":5E-15,"d":"5.00E-15"},"COG1226","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0034765|regulation of ion transmembrane transport;GO:0051260|protein homooligomerization;GO:0071805|potassium ion transmembrane transport;","GO:0008076|voltage-gated potassium channel complex;GO:0016021|integral component of membrane;","GO:0005249|voltage-gated potassium channel activity;","K04935","KCNV2, KV8.2; potassium channel subfamily V member 2"]
["ENSRNOG00000033792",4,0.336541075,21,1.350939202,0.249116373,-2.005108248,0.002802595,0.001999698,"down","yes","RGD1561413","protein_coding","chr5:158083294-158120229:-","gi|564306430|ref|XP_006225669.1|",2920,0,"PREDICTED: zinc finger protein OZF-like isoform X1 [Rattus norvegicus]","gi|672020104|ref|XM_006225607.2|",3214,0,"PREDICTED: Rattus norvegicus similar to BC021442 protein (RGD1561413), transcript variant X1, mRNA","Q8TAQ5",511,{"v":4e-164,"d":"4.00E-164"},"Zinc finger protein 420",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000063087",4,0.336541075,21,1.350939202,0.249116373,-2.005108248,0.002802595,0.001999698,"down","yes","ENSRNOG00000063087","protein_coding","chr3:143138332-143139527:+","gi|344250492|gb|EGW06596.1|",918,{"v":5e-118,"d":"5.00E-118"},"Elongation factor 1-alpha 1 [Cricetulus griseus]","gi|672047760|ref|XR_591795.1|",774,0,"PREDICTED: Rattus norvegicus elongation factor 1-alpha 1 pseudogene (LOC103691939), misc_RNA","P62630",262,{"v":1e-82,"d":"1.00E-82"},"Elongation factor 1-alpha 1","SPBC839.15c",230,{"v":4e-71,"d":"4.00E-71"},"COG5256","pfam03143","GTP_EFTU_D3","Elongation factor Tu C-terminal domain. Elongation factor Tu consists of three structural domains, this is the third domain. This domain adopts a beta barrel structure. This the third domain is involved in binding to both charged tRNA and binding to EF-Ts pfam00889.",".",".",".",".","."]
["ENSRNOG00000008869",22,1.85097591,58,3.731165415,0.496085192,-1.011340202,0.002921166,2.076952E-3,"down","yes","Ppp1r9a","protein_coding","chr4:33024450-33286907:+","gi|564345694|ref|XP_006236126.1|",6362,0,"PREDICTED: neurabin-1 isoform X4 [Rattus norvegicus]","gi|672048932|ref|XM_006236064.2|",4419,0,"PREDICTED: Rattus norvegicus protein phosphatase 1, regulatory subunit 9A (Ppp1r9a), transcript variant X5, mRNA","O35867",1769,0,"Neurabin-1",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.","GO:0007015|actin filament organization;GO:0007568|aging;GO:0010976|positive regulation of neuron projection development;GO:0019722|calcium-mediated signaling;GO:0030833|regulation of actin filament polymerization;GO:0031175|neuron projection development;GO:0045860|positive regulation of protein kinase activity;GO:0048666|neuron development;GO:0050804|modulation of chemical synaptic transmission;GO:0051489|regulation of filopodium assembly;GO:0051497|negative regulation of stress fiber assembly;GO:0051823|regulation of synapse structural plasticity;GO:0051963|regulation of synapse assembly;GO:0060079|excitatory postsynaptic potential;GO:0060999|positive regulation of dendritic spine development;GO:0061001|regulation of dendritic spine morphogenesis;GO:0097237|cellular response to toxic substance;GO:0098974|postsynaptic actin cytoskeleton organization;GO:1900272|negative regulation of long-term synaptic potentiation;GO:1900454|positive regulation of long-term synaptic depression;GO:1904049|negative regulation of spontaneous neurotransmitter secretion;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0014069|postsynaptic density;GO:0015629|actin cytoskeleton;GO:0030027|lamellipodium;GO:0030175|filopodium;GO:0030425|dendrite;GO:0030426|growth cone;GO:0030864|cortical actin cytoskeleton;GO:0031594|neuromuscular junction;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043197|dendritic spine;GO:0044326|dendritic spine neck;GO:0045202|synapse;GO:0098871|postsynaptic actin cytoskeleton;GO:0098978|glutamatergic synapse;GO:1990761|growth cone lamellipodium;","GO:0005515|protein binding;GO:0008022|protein C-terminus binding;GO:0008157|protein phosphatase 1 binding;GO:0019901|protein kinase binding;GO:0019904|protein domain specific binding;GO:0042802|identical protein binding;GO:0044325|ion channel binding;GO:0044877|protein-containing complex binding;GO:0051015|actin filament binding;GO:0051020|GTPase binding;","K17551","PPP1R9; neurabin"]
["ENSRNOG00000007574",7,0.588946881,28,1.801252269,0.32696524,-1.612790825,0.002968349,0.002107747,"down","yes","Padi2","protein_coding","chr5:153209053-153251632:+","gi|149024452|gb|EDL80949.1|",3471,0,"peptidyl arginine deiminase, type II, isoform CRA_a [Rattus norvegicus]","gi|8393934|ref|NM_017226.1|",4370,0,"Rattus norvegicus peptidyl arginine deiminase, type II (Padi2), mRNA","P20717",1341,0,"Protein-arginine deiminase type-2",".",".",".",".","pfam03068","PAD","Protein-arginine deiminase (PAD). Members of this family are found in mammals. In the presence of calcium ions, PAD enzymes EC:3.5.3.15 catalyse the post-translational modification reaction responsible for the formation of citrulline residues: Protein L-arginine + H2O <=> Protein L-citrulline + NH3. Several types are recognized (and included in the family) on the basis of molecular mass, substrate specificity, and tissue localisation. The expression of type I PAD is known to be under the control of oestrogen.","GO:0010848|regulation of chromatin disassembly;GO:0018101|protein citrullination;GO:0021762|substantia nigra development;GO:0030520|intracellular estrogen receptor signaling pathway;GO:0036413|histone H3-R26 citrullination;GO:0036414|histone citrullination;GO:0048096|chromatin-mediated maintenance of transcription;GO:0070100|negative regulation of chemokine-mediated signaling pathway;GO:1901624|negative regulation of lymphocyte chemotaxis;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0035327|transcriptionally active chromatin;","GO:0004668|protein-arginine deiminase activity;GO:0005509|calcium ion binding;GO:0030331|estrogen receptor binding;GO:0042803|protein homodimerization activity;","K01481","E3.5.3.15; protein-arginine deiminase [EC:3.5.3.15]"]
["ENSRNOG00000065514",7,0.588946881,28,1.801252269,0.32696524,-1.612790825,0.002968349,0.002107747,"down","yes","Ubxn2a","protein_coding","chr20:52408176-52409580:+","gi|157823317|ref|NP_001102952.1|",1124,{"v":2E-149,"d":"2.00E-149"},"UBX domain-containing protein 2A [Rattus norvegicus]","gi|157823316|ref|NM_001109482.1|",1396,0,"Rattus norvegicus UBX domain protein 2A (Ubxn2a), mRNA","Q99KJ0",425,{"v":3e-146,"d":"3.00E-146"},"UBX domain-containing protein 2A",".",".",".",".","pfam08059","SEP","SEP domain. The SEP domain is named after Saccharomyces cerevisiae Shp1, Drosophila melanogaster eyes closed gene (eyc), and vertebrate p47. In p47, the SEP domain has been shown to bind to and inhibit the cysteine protease cathepsin L. Most SEP domains are succeeded closely by a UBX domain.",".",".",".",".","."]
["ENSRNOG00000000277",8,0.673082149,30,1.929913146,0.348762923,-1.519681421,3.230948E-3,0.002277873,"down","yes","Tet1","protein_coding","chr20:25768120-25833052:+","gi|564322123|ref|XP_006223942.1|",10446,0,"PREDICTED: methylcytosine dioxygenase TET1 [Rattus norvegicus]","gi|672031733|ref|XM_008774952.1|",5241,0,"PREDICTED: Rattus norvegicus tet methylcytosine dioxygenase 1 (Tet1), transcript variant X2, mRNA","Q3URK3",3193,0,"Methylcytosine dioxygenase TET1",".",".",".",".","pfam12851","Tet_JBP","Oxygenase domain of the 2OGFeDO superfamily. A double-stranded beta helix (DSBH) fold domain of the 2-oxoglutarate (2OG)-Fe(II)-dependent dioxygenase (2OGFeDO) superfamily found in various eukaryotes, bacteria and bacteriophages. Members of this family catalyze nucleic acid modifications, such as thymidine hydroxylation during base J synthesis in kinetoplastids, and the conversion of 5 methyl-cytosine (5-mC) to 5-hydroxymethyl-cytosine (hmC), or further oxidation to 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). Metazoan TET proteins contain a cysteine-rich region inserted into the core of the DSBH fold. Vertebrate TET proteins are oncogenes that are mutated in various myeloid cancers. Fungal and algal versions of this family are linked to a predicted transposase and show lineage-specific expansions.","GO:0001826|inner cell mass cell differentiation;GO:0006211|5-methylcytosine catabolic process;GO:0006493|protein O-linked glycosylation;GO:0008150|biological_process;GO:0008284|positive regulation of cell proliferation;GO:0019827|stem cell population maintenance;GO:0031062|positive regulation of histone methylation;GO:0044030|regulation of DNA methylation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048813|dendrite morphogenesis;GO:0070989|oxidative demethylation;GO:0080111|DNA demethylation;GO:0090310|negative regulation of methylation-dependent chromatin silencing;GO:2000653|regulation of genetic imprinting;","GO:0005575|cellular_component;GO:0005634|nucleus;","GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0005506|iron ion binding;GO:0008270|zinc ion binding;GO:0008327|methyl-CpG binding;GO:0070579|methylcytosine dioxygenase activity;","K13097","TET1; methylcytosine dioxygenase [EC:1.14.11.-]"]
["ENSRNOG00000008001",8,0.673082149,30,1.929913146,0.348762923,-1.519681421,3.230948E-3,0.002277873,"down","yes","Rab3b","protein_coding","chr5:123644423-123697401:+","gi|564352032|ref|XP_006238593.1|",1233,{"v":2e-168,"d":"2.00E-168"},"PREDICTED: ras-related protein Rab-3B isoform X1 [Rattus norvegicus]","gi|672053258|ref|XM_006238531.2|",1051,0,"PREDICTED: Rattus norvegicus RAB3B, member RAS oncogene family (Rab3b), transcript variant X1, mRNA","Q63941",450,{"v":2e-158,"d":"2.00E-158"},"Ras-related protein Rab-3B",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0006904|vesicle docking involved in exocytosis;GO:0009306|protein secretion;GO:0017157|regulation of exocytosis;GO:0018125|peptidyl-cysteine methylation;GO:0019882|antigen processing and presentation;GO:0051586|positive regulation of dopamine uptake involved in synaptic transmission;GO:0072659|protein localization to plasma membrane;GO:0097494|regulation of vesicle size;GO:0098693|regulation of synaptic vesicle cycle;","GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0008021|synaptic vesicle;GO:0030141|secretory granule;GO:0031982|vesicle;GO:0048471|perinuclear region of cytoplasm;GO:0098691|dopaminergic synapse;GO:0098993|anchored component of synaptic vesicle membrane;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0019003|GDP binding;GO:0030742|GTP-dependent protein binding;GO:0031489|myosin V binding;","K06108","RAB3B; Ras-related protein Rab-3B"]
["ENSRNOG00000053728",8,0.673082149,30,1.929913146,0.348762923,-1.519681421,3.230948E-3,0.002277873,"down","yes","AABR07006724.1","protein_coding","chr1:228408947-229639080:-","gi|354476119|ref|XP_003500272.1|",3106,0,"PREDICTED: cGMP-dependent protein kinase 1 [Cricetulus griseus]","gi|625193216|ref|XM_003500224.2|",2510,0,"PREDICTED: Cricetulus griseus protein kinase, cGMP-dependent, type I (Prkg1), mRNA","P0C605",1073,0,"cGMP-dependent protein kinase 1",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.",".",".",".",".","."]
["ENSRNOG00000004327",3,0.252405806,18,1.157947887,0.217976827,-2.197753326,0.00335519,2.355705E-3,"down","yes","Ddc","protein_coding","chr14:86378685-86469208:-","gi|564384864|ref|XP_006251536.1|",2566,0,"PREDICTED: aromatic-L-amino-acid decarboxylase isoform X3 [Rattus norvegicus]","gi|399498499|ref|NM_001270852.1|",5094,0,"Rattus norvegicus dopa decarboxylase (Ddc), transcript variant 3, mRNA","P14173",968,0,"Aromatic-L-amino-acid decarboxylase","mll0712",311,{"v":5e-92,"d":"5.00E-92"},"COG0076","pfam00282","Pyridoxal_deC","Pyridoxal-dependent decarboxylase conserved domain.","GO:0006520|cellular amino acid metabolic process;GO:0006584|catecholamine metabolic process;GO:0007623|circadian rhythm;GO:0009636|response to toxic substance;GO:0010259|multicellular organism aging;GO:0015842|aminergic neurotransmitter loading into synaptic vesicle;GO:0033076|isoquinoline alkaloid metabolic process;GO:0042416|dopamine biosynthetic process;GO:0042417|dopamine metabolic process;GO:0042423|catecholamine biosynthetic process;GO:0042427|serotonin biosynthetic process;GO:0046684|response to pyrethroid;GO:0052314|phytoalexin metabolic process;GO:0071312|cellular response to alkaloid;GO:0071363|cellular response to growth factor stimulus;GO:0071466|cellular response to xenobiotic stimulus;","GO:0005737|cytoplasm;GO:0008021|synaptic vesicle;GO:0030424|axon;GO:0043025|neuronal cell body;","GO:0004058|aromatic-L-amino-acid decarboxylase activity;GO:0005515|protein binding;GO:0016597|amino acid binding;GO:0016831|carboxy-lyase activity;GO:0019899|enzyme binding;GO:0019904|protein domain specific binding;GO:0030170|pyridoxal phosphate binding;GO:0036467|5-hydroxy-L-tryptophan decarboxylase activity;GO:0036468|L-dopa decarboxylase activity;","K01593","DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase [EC:4.1.1.28 4.1.1.105]"]
["ENSRNOG00000056434",3,0.252405806,18,1.157947887,0.217976827,-2.197753326,0.00335519,2.355705E-3,"down","yes","Gm25663","snoRNA","chr13:55522359-55522493:+",".",".",".",".","gi|564380983|ref|XR_358970.1|",135,{"v":3e-63,"d":"3.00E-63"},"PREDICTED: Rattus norvegicus uncharacterized LOC102549528 (LOC102549528), ncRNA",".",".",".",".",".",".",".",".","pfam10143","PhosphMutase","2,3-bisphosphoglycerate-independent phosphoglycerate mutase. Members of this family are found in various bacterial 2,3-bisphosphoglycerate-independent phosphoglycerate mutase enzymes, which catalyse the interconversion of 2-phosphoglycerate and 3-phosphoglycerate in the reaction: [2-phospho-D-glycerate + 2,3-diphosphoglycerate = 3-phospho-D-glycerate + 2,3-diphosphoglycerate].",".",".",".",".","."]
["ENSRNOG00000060308",3,0.252405806,18,1.157947887,0.217976827,-2.197753326,0.00335519,2.355705E-3,"down","yes","AC115420.4","protein_coding","chr4:157725613-157734182:+","gi|149049453|gb|EDM01907.1|",505,{"v":1E-62,"d":"1.00E-62"},"rCG63419 [Rattus norvegicus]","gi|755518350|ref|XR_105027.3|",211,{"v":6e-105,"d":"6.00E-105"},"PREDICTED: Mus musculus RIKEN cDNA A230083G16 gene (A230083G16Rik), misc_RNA",".",".",".",".",".",".",".",".","pfam06027","DUF914","Eukaryotic protein of unknown function (DUF914). This family consists of several hypothetical proteins of unknown function. Some of the sequences in this family are annotated as being putative membrane proteins.",".",".",".",".","."]
["ENSRNOG00000064950",3,0.252405806,18,1.157947887,0.217976827,-2.197753326,0.00335519,2.355705E-3,"down","yes","ENSRNOG00000064950","protein_coding","chr3:145508997-145532381:-","gi|62078575|ref|NP_001013945.1|",1583,0,"protein NDRG3 [Rattus norvegicus]","gi|62078574|ref|NM_001013923.1|",2352,0,"Rattus norvegicus NDRG family member 3 (Ndrg3), mRNA","Q6AYR2",614,0,"Protein NDRG3",".",".",".",".","pfam03096","Ndr","Ndr family. This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, and Ndr3. Their similarity was previously noted. The precise molecular and cellular function of members of this family is still unknown. Yet, they are known to be involved in cellular differentiation events. The Ndr1 group was the first to be discovered. Their expression is repressed by the proto-oncogenes N-myc and c-myc, and in line with this observation, Ndr1 protein expression is down-regulated in neoplastic cells, and is reactivated when differentiation is induced by chemicals such as retinoic acid. Ndr2 and Ndr3 expression is not under the control of N-myc or c-myc. Ndr1 expression is also activated by several chemicals: tunicamycin and homocysteine induce Ndr1 in human umbilical endothelial cells; nickel induces Ndr1 in several cell types. Members of this family are found in wide variety of multicellular eukaryotes, including an Ndr1 type protein in Helianthus annuus (sunflower), known as Sf21. Interestingly, the highest scoring matches in the noise are all alpha/beta hydrolases pfam00561, suggesting that this family may have an enzymatic function (Bateman A pers. obs.).",".",".",".",".","."]
["ENSRNOG00000065330",3,0.252405806,18,1.157947887,0.217976827,-2.197753326,0.00335519,2.355705E-3,"down","yes","Mrgpre","protein_coding","chr1:198963787-198969521:-","gi|50511332|ref|NP_001002288.1|",1296,{"v":7e-165,"d":"7.00E-165"},"mas-related G-protein coupled receptor member E [Rattus norvegicus]","gi|672039458|ref|XM_008760163.1|",3398,0,"PREDICTED: Rattus norvegicus MAS-related GPR, member E (Mrgpre), transcript variant X2, mRNA","Q7TN40",503,{"v":2e-166,"d":"2.00E-166"},"Mas-related G-protein coupled receptor member E",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.",".",".",".",".","."]
["ENSRNOG00000004222",1,0.084135269,12,0.771965258,0.108988413,-3.197753326,0.003387222,0.002375438,"down","yes","S100g","protein_coding","chrX:31705866-31708433:+","gi|564399101|ref|XP_006256950.1|",362,{"v":1E-41,"d":"1.00E-41"},"PREDICTED: protein S100-G isoform X1 [Rattus norvegicus]","gi|672087298|ref|XM_006256888.2|",439,0,"PREDICTED: Rattus norvegicus S100 calcium binding protein G (S100g), transcript variant X1, mRNA","P02634",137,{"v":1e-40,"d":"1.00E-40"},"Protein S100-G",".",".",".",".","pfam01023","S_100","S-100/ICaBP type calcium binding domain. The S-100 domain is a subfamily of the EF-hand calcium binding proteins.","GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;","GO:0003674|molecular_function;GO:0005499|vitamin D binding;GO:0005509|calcium ion binding;GO:0046914|transition metal ion binding;GO:0048306|calcium-dependent protein binding;","K14734","S100G; protein S100-G"]
["ENSRNOG00000016353",1,0.084135269,12,0.771965258,0.108988413,-3.197753326,0.003387222,0.002375438,"down","yes","Nim1k","protein_coding","chr2:51670772-51714762:-","gi|62642955|ref|XP_227081.3|",2336,0,"PREDICTED: serine/threonine-protein kinase NIM1 [Rattus norvegicus]","gi|672041654|ref|XM_006231982.2|",2330,0,"PREDICTED: Rattus norvegicus NIM1 serine/threonine protein kinase (Nim1k), transcript variant X2, mRNA","Q8BHI9",869,0,"Serine/threonine-protein kinase NIM1",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006468|protein phosphorylation;GO:0035556|intracellular signal transduction;GO:0042149|cellular response to glucose starvation;",".","GO:0000287|magnesium ion binding;GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;","K16310","NIM1; serine/threonine-protein kinase NIM1 [EC:2.7.11.1]"]
["ENSRNOG00000039568",1,0.084135269,12,0.771965258,0.108988413,-3.197753326,0.003387222,0.002375438,"down","yes","Mgat4e","protein_coding","chr13:45982164-46001050:-","gi|564315792|ref|XP_006221537.1|",2335,0,"PREDICTED: alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein [Rattus norvegicus]","gi|672027117|ref|XM_008762290.1|",1556,0,"PREDICTED: Rattus norvegicus similar to 40S ribosomal protein S7 (S8) (RGD1308112), transcript variant X3, mRNA","A6H684",615,0,"Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4E",".",".",".",".","pfam04666","Glyco_transf_54","N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region. The complex-type of oligosaccharides are synthesized through elongation by glycosyltransferases after trimming of the precursor oligosaccharides transferred to proteins in the endoplasmic reticulum. N-Acetylglucosaminyltransferases (GnTs) take part in the formation of branches in the biosynthesis of complex-type sugar chains. In vertebrates, six GnTs, designated as GnT-I to -VI, which catalyse the transfer of GlcNAc to the core mannose residues of Asn-linked sugar chains, have been identified. GnT-IV (EC:2.4.1.145) catalyses the transfer of GlcNAc from UDP-GlcNAc to the GlcNAc1-2Man1-3 arm of core oligosaccharide [Gn2(22)core oligosaccharide] and forms GlcNAc1-4(GlcNAc1-2)Man1-3 structure on the core oligosaccharide (Gn3(2,4,2)core oligosaccharide). In some members the conserved region occupies all but the very for N-terminal, where there is a signal sequence on all members. For other members the conserved region does not occupy the entire protein but is still to the N-terminus of the protein.","GO:0006487|protein N-linked glycosylation;","GO:0016021|integral component of membrane;","GO:0008375|acetylglucosaminyltransferase activity;",".","."]
["ENSRNOG00000048823",1,0.084135269,12,0.771965258,0.108988413,-3.197753326,0.003387222,0.002375438,"down","yes","AABR07007146.1","protein_coding","chr19:28520-37732:-","gi|392334284|ref|XP_001056053.3|",3011,0,"PREDICTED: pyrethroid hydrolase Ces2e [Rattus norvegicus]","gi|672030984|ref|XM_001056053.5|",1968,0,"PREDICTED: Rattus norvegicus similar to carboxylesterase 5 (LOC679368), mRNA","Q8BK48",1053,0,"Pyrethroid hydrolase Ces2e","BS_pnbA",268,{"v":2e-80,"d":"2.00E-80"},"COG2272","pfam00135","COesterase","Carboxylesterase family.",".",".",".",".","."]
["ENSRNOG00000063651",1,0.084135269,12,0.771965258,0.108988413,-3.197753326,0.003387222,0.002375438,"down","yes","ENSRNOG00000063651","lncRNA","chr20:17943254-18024429:-","gi|148677466|gb|EDL09413.1|",185,{"v":8E-14,"d":"8.00E-14"},"mCG147326 [Mus musculus]","gi|672031653|ref|XR_599394.1|",583,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102548544 (LOC102548544), ncRNA",".",".",".",".",".",".",".",".","pfam04632","FUSC","Fusaric acid resistance protein family. This family includes a conserved region found in two proteins associated with fusaric acid resistance, from Burkholderia cepacia and Klebsiella oxytoca. These proteins are likely to be membrane transporter proteins.",".",".",".",".","."]
["ENSRNOG00000064689",1,0.084135269,12,0.771965258,0.108988413,-3.197753326,0.003387222,0.002375438,"down","yes","ENSRNOG00000064689","lncRNA","chr8:99216863-99239322:+",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","pfam00967","Barwin","Barwin family.",".",".",".",".","."]
["ENSRNOG00000066166",1,0.084135269,12,0.771965258,0.108988413,-3.197753326,0.003387222,0.002375438,"down","yes","ENSRNOG00000066166","protein_coding","chr13:62124375-62124887:+","gi|149031733|gb|EDL86683.1|",920,{"v":1e-116,"d":"1.00E-116"},"rCG41266 [Rattus norvegicus]","gi|298903500|emb|FQ209715.1|",498,0,"Rattus norvegicus TL0ABA40YN22 mRNA sequence","B1WC58",358,{"v":4e-117,"d":"4.00E-117"},"DNA endonuclease RBBP8",".",".",".",".","pfam08573","SAE2","DNA repair protein endonuclease SAE2/CtIP C-terminus. SAE2 is a protein involved in repairing meiotic and mitotic double-strand breaks in DNA. It has been shown to negatively regulate DNA damage checkpoint signalling. SAE2 is homologous to the CtIP proteins in mammals and an homologous protein in plants. Crucial sequence motifs that are highly conserved are the CxxC and the RHR motifs in this C-terminal part of the protein. It is now known to be an endonuclease. In budding yeast, genetic evidence suggests that the SAE2 protein is essential for the processing of hairpin DNA intermediates and meiotic double-strand breaks by Mre11/Rad50 complexes. SAE2 binds DNA and exhibits endonuclease activity on single-stranded DNA independently of Mre11/Rad50 complexes, but hairpin DNA structures are cleaved cooperatively in the presence of Mre11/Rad50 or Mre11/Rad50/Xrs2. Hairpin structures are not processed at the tip by SAE2 but rather at single-stranded DNA regions adjacent to the hairpin. The catalytic activities of SAE2 are important for its biological functions.",".",".",".",".","."]
["ENSRNOG00000067667",1,0.084135269,12,0.771965258,0.108988413,-3.197753326,0.003387222,0.002375438,"down","yes","ENSRNOG00000067667","lncRNA","chr7:67465403-67474331:+",".",".",".",".","gi|672021786|ref|XR_601781.1|",91,{"v":8e-38,"d":"8.00E-38"},"PREDICTED: Rattus norvegicus uncharacterized LOC102554106 (LOC102554106), ncRNA",".",".",".",".",".",".",".",".","pfam08569","Mo25","Mo25-like. Mo25-like proteins are involved in both polarised growth and cytokinesis. In fission yeast Mo25 is localized alternately to the spindle pole body and to the site cell division in a cell cycle dependent manner.",".",".",".",".","."]
["ENSRNOG00000064160",9,0.757217418,32,2.058574022,0.367835895,-1.442865824,0.003429057,0.002400448,"down","yes","ENSRNOG00000064160","lncRNA","chr1:39020173-39029307:-","gi|672033170|ref|XP_008756361.1|",348,{"v":1e-37,"d":"1.00E-37"},"PREDICTED: LOW QUALITY PROTEIN: T-cell activation Rho GTPase-activating protein-like [Rattus norvegicus]","gi|672012669|ref|XR_598633.1|",325,{"v":2e-168,"d":"2.00E-168"},"PREDICTED: Rattus norvegicus rho GTPase-activating protein 20-like (LOC102556805), transcript variant X8, misc_RNA",".",".",".",".",".",".",".",".","pfam06398","Pex24p","Integral peroxisomal membrane peroxin. Peroxisomes play diverse roles in the cell, compartmentalising many activities related to lipid metabolizm and functioning in the decomposition of toxic hydrogen peroxide. Sequence similarity was identified between two hypothetical proteins and the peroxin integral membrane protein Pex24p.",".",".",".",".","."]
["ENSRNOG00000013306",5,0.420676343,23,1.479600078,0.2843176,-1.814424686,3.441015E-3,0.002406981,"down","yes","Pcdh20","protein_coding","chr15:64425534-64431790:-","gi|157822707|ref|NP_001100750.1|",4607,0,"protocadherin-20 [Rattus norvegicus]","gi|157822706|ref|NM_001107280.1|",5179,0,"Rattus norvegicus protocadherin 20 (Pcdh20), mRNA","Q8BIZ0",1738,0,"Protocadherin-20",".",".",".",".","pfam00028","Cadherin","Cadherin domain.","GO:0007155|cell adhesion;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;","GO:0005887|integral component of plasma membrane;","GO:0005509|calcium ion binding;","K16498","PCDHD1; protocadherin delta 1"]
["ENSRNOG00000067892",5,0.420676343,23,1.479600078,0.2843176,-1.814424686,3.441015E-3,0.002406981,"down","yes","ENSRNOG00000067892","lncRNA","chr1:205619205-205622461:+","gi|149062285|gb|EDM12708.1|",267,{"v":2e-26,"d":"2.00E-26"},"rCG47316, isoform CRA_d [Rattus norvegicus]","gi|766944340|ref|NR_131096.1|",568,0,"Rattus norvegicus uncharacterized LOC100912041 (LOC100912041), long non-coding RNA",".",".",".",".",".",".",".",".","pfam11046","HycA_repressor","Transcriptional repressor of hyc and hyp operons. This family is conserved in Proteobacteria. It is likely to be the transcriptional repressor molecule for the hyc and hyp operons, which express, amongst others, the protein HycA. This protein may be harnessed for the reduction of technetium oxide, an unwelcome product of radio-nucleotide bioaccumulation. HycA produces formate hydrogenlyase, one of the key proteins necessary for metal compound reduction.",".",".",".",".","."]
["ENSRNOG00000008057",17,1.430299567,48,3.087861033,0.463200757,-1.110290485,0.003482479,0.002432841,"down","yes","ENSRNOG00000008057","protein_coding","chr7:132528895-132545052:+","gi|392341701|ref|XP_003754401.1|",2266,0,"PREDICTED: keratin, type II cytoskeletal 7 [Rattus norvegicus]","gi|672022401|ref|XM_003754353.3|",1476,0,"PREDICTED: Rattus norvegicus keratin 7 (Krt7), mRNA","Q6IG12",818,0,"Keratin, type II cytoskeletal 7",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0045095|keratin filament;","GO:0003674|molecular_function;","K07605","KRT2; type II keratin, basic"]
["ENSRNOG00000067844",17,1.430299567,48,3.087861033,0.463200757,-1.110290485,0.003482479,0.002432841,"down","yes","ENSRNOG00000067844","protein_coding","chrX:19563517-19572953:-","gi|595582214|ref|NP_001277700.1|",1229,{"v":4E-160,"d":"4.00E-160"},"trophinin isoform 4 [Mus musculus]","gi|672032140|ref|XM_008758390.1|",754,0,"PREDICTED: Rattus norvegicus trophinin-like (LOC100912141), transcript variant X2, mRNA","Q12816",434,{"v":2e-139,"d":"2.00E-139"},"Trophinin",".",".",".",".","pfam01454","MAGE","MAGE family. The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumors but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.",".",".",".",".","."]
["ENSRNOG00000005070",16,1.346164298,46,2.959200157,0.45490816,-1.136352781,0.003568038,2.487366E-3,"down","yes","Spopl","protein_coding","chr3:6078310-6108794:-","gi|197313767|ref|NP_001127919.1|",1991,0,"speckle-type POZ protein-like [Rattus norvegicus]","gi|755498014|ref|XM_011239209.1|",1241,0,"PREDICTED: Mus musculus speckle-type POZ protein-like (Spopl), transcript variant X4, mRNA","Q2M2N2",739,0,"Speckle-type POZ protein-like",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.","GO:0030162|regulation of proteolysis;GO:0031397|negative regulation of protein ubiquitination;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0031463|Cul3-RING ubiquitin ligase complex;","GO:0031625|ubiquitin protein ligase binding;","K10523","SPOP; speckle-type POZ protein"]
["ENSRNOG00000005109",2,0.168270537,15,0.964956573,0.174381461,-2.519681421,0.003692999,0.002567392,"down","yes","Rprm","protein_coding","chr3:38539581-38540998:-","gi|112984092|ref|NP_001037741.1|",562,{"v":3e-67,"d":"3.00E-67"},"protein reprimo [Rattus norvegicus]","gi|672045340|ref|XM_008761775.1|",1418,0,"PREDICTED: Rattus norvegicus reprimo, TP53 dependent G2 arrest mediator candidate (Rprm), transcript variant X1, mRNA","Q5BJN9",221,{"v":1e-68,"d":"1.00E-68"},"Protein reprimo",".",".",".",".","pfam12737","Mating_C","C-terminal domain of homeodomain 1. Mating in fungi is controlled by the loci that determine the mating type of an individual, and only individuals with differing mating types can mate. Basidiomycete fungi have evolved a unique mating system, termed tetrapolar or bifactorial incompatibility, in which mating type is determined by two unlinked loci; compatibility at both loci is required for mating to occur. The multi-allelic tetrapolar mating system is considered to be a novel innovation that could have only evolved once, and is thus unique to the mushroom fungi. This domain is C-terminal to the homeodomain transcription factor region.","GO:0007346|regulation of mitotic cell cycle;GO:0051726|regulation of cell cycle;","GO:0005737|cytoplasm;GO:0016021|integral component of membrane;",".","K10128","RPRM; reprimo, TP53-dependent G2 arrest mediator candidate"]
["ENSRNOG00000010459",2,0.168270537,15,0.964956573,0.174381461,-2.519681421,0.003692999,0.002567392,"down","yes","Fbxo43","protein_coding","chr7:67333162-67346751:-","gi|209915571|ref|NP_001012117.2|",3170,0,"F-box only protein 43 [Rattus norvegicus]","gi|58865803|ref|NM_001012117.1|",2525,0,"Rattus norvegicus F-box protein 43 (Fbxo43), mRNA","Q66H04",1223,0,"F-box only protein 43",".",".",".",".","pfam01485","IBR","IBR domain. The IBR (In Between Ring fingers) domain is often found to occur between pairs of ring fingers (pfam00097). This domain has also been called the C6HC domain and DRIL (for double RING finger linked) domain. Proteins that contain two Ring fingers and an IBR domain (these proteins are also termed RBR family proteins) are thought to exist in all eukaryotic organisms. RBR family members play roles in protein quality control and can indirectly regulate transcription. Evidence suggests that RBR proteins are often parts of cullin-containing ubiquitin ligase complexes. The ubiquitin ligase Parkin is an RBR family protein whose mutations are involved in forms of familial Parkinson's disease.","GO:0007088|regulation of mitotic nuclear division;GO:0016567|protein ubiquitination;GO:0040020|regulation of meiotic nuclear division;GO:0042177|negative regulation of protein catabolic process;GO:0045835|negative regulation of meiotic nuclear division;GO:0051321|meiotic cell cycle;","GO:0005634|nucleus;","GO:0046872|metal ion binding;","K10318","FBXO43, EMI2; F-box protein 43"]
["ENSRNOG00000013262",2,0.168270537,15,0.964956573,0.174381461,-2.519681421,0.003692999,0.002567392,"down","yes","Myl1","protein_coding","chr9:68437517-68458261:-","gi|149016008|gb|EDL75289.1|",942,{"v":3E-122,"d":"3.00E-122"},"fast myosin alkali light chain, isoform CRA_c [Rattus norvegicus]","gi|298896366|emb|FQ215500.1|",1532,0,"Rattus norvegicus TL0ACA48YA04 mRNA sequence","P02600",291,{"v":3e-94,"d":"3.00E-94"},"Myosin light chain 1/3, skeletal muscle isoform","SPAC3A12.14",106,{"v":6e-26,"d":"6.00E-26"},"COG5126","pfam13499","EF-hand_7","EF-hand domain pair.","GO:0006936|muscle contraction;GO:0060048|cardiac muscle contraction;","GO:0016459|myosin complex;GO:0030016|myofibril;GO:0043292|contractile fiber;","GO:0005509|calcium ion binding;GO:0008307|structural constituent of muscle;","K05738","MYL1; myosin light chain 1"]
["ENSRNOG00000064037",2,0.168270537,15,0.964956573,0.174381461,-2.519681421,0.003692999,0.002567392,"down","yes","Hpse2","protein_coding","chr1:241583187-242246118:-","gi|672040510|ref|XP_008758667.1|",2528,0,"PREDICTED: inactive heparanase-2 isoform X1 [Rattus norvegicus]","gi|672040509|ref|XM_008760445.1|",2378,0,"PREDICTED: Rattus norvegicus heparanase 2 (Hpse2), transcript variant X1, mRNA","B2RY83",962,0,"Inactive heparanase-2",".",".",".",".","pfam03662","Glyco_hydro_79n","Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesized as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumor cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity.",".",".",".",".","."]
["ENSRNOG00000068252",2,0.168270537,15,0.964956573,0.174381461,-2.519681421,0.003692999,0.002567392,"down","yes","Olr1646","protein_coding","chr15:27729827-27736945:-","gi|47576567|ref|NP_001000103.1|",1426,{"v":3e-177,"d":"3.00E-177"},"olfactory receptor Olr1646 [Rattus norvegicus]","gi|218511252|gb|AC097037.8|",6375,0,"Rattus norvegicus CH230-20D8 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q9Z1V0",514,{"v":9e-165,"d":"9.00E-165"},"Olfactory receptor 49",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.",".",".",".",".","."]
["ENSRNOG00000026514",12,1.009623224,38,2.444556651,0.413008724,-1.275755838,0.003702226,0.002573478,"down","yes","Wdr93","protein_coding","chr1:133687248-133733630:+","gi|300794534|ref|NP_001178878.1|",3523,0,"WD repeat-containing protein 93 [Rattus norvegicus]","gi|672037135|ref|XM_008759549.1|",2310,0,"PREDICTED: Rattus norvegicus WD repeat domain 93 (Wdr93), transcript variant X6, mRNA","Q402B2",1136,0,"WD repeat-containing protein 93",".",".",".",".","pfam00780","CNH","CNH domain. Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished observations.","GO:0022900|electron transport chain;","GO:0005747|mitochondrial respiratory chain complex I;","GO:0016651|oxidoreductase activity, acting on NAD(P)H;","K24762","WDR93; WD repeat-containing protein 93"]
["ENSRNOG00000056746",13,1.093758492,40,2.573217527,0.425054812,-1.234279202,0.003709697,0.002578013,"down","yes","Tchh","protein_coding","chr2:179109609-179110985:+","gi|672015998|ref|XP_008773413.1|",212,{"v":1e-15,"d":"1.00E-15"},"PREDICTED: trichohyalin isoform X3 [Rattus norvegicus]","gi|672043308|ref|XM_006232820.2|",547,0,"PREDICTED: Rattus norvegicus trichohyalin (Tchh), transcript variant X1, mRNA","P37709",67.4,{"v":8e-11,"d":"8.00E-11"},"Trichohyalin",".",".",".",".","pfam03814","KdpA","Potassium-transporting ATPase A subunit.","GO:0045109|intermediate filament organization;",".","GO:0005509|calcium ion binding;GO:0030674|protein binding, bridging;GO:0046914|transition metal ion binding;","K18626","TCHH; trichohyalin"]
["ENSRNOG00000006486",0,0.042067634,10,0.643304382,0.065393048,-3.93471892,0.00377009,2.613644E-3,"down","yes","Reg1a","protein_coding","chr4:110892453-110895570:+","gi|6981470|ref|NP_036773.1|",884,{"v":2e-115,"d":"2.00E-115"},"lithostathine precursor [Rattus norvegicus]","gi|298911377|emb|FQ219465.1|",1073,0,"Rattus norvegicus TL0ABA45YB05 mRNA sequence","P10758",345,{"v":6e-117,"d":"6.00E-117"},"Lithostathine",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0001666|response to hypoxia;GO:0001934|positive regulation of protein phosphorylation;GO:0003309|type B pancreatic cell differentiation;GO:0007494|midgut development;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0010467|gene expression;GO:0010628|positive regulation of gene expression;GO:0014065|phosphatidylinositol 3-kinase signaling;GO:0014070|response to organic cyclic compound;GO:0031667|response to nutrient levels;GO:0042060|wound healing;GO:0043434|response to peptide hormone;GO:0044278|cell wall disruption in other organism;GO:0055074|calcium ion homeostasis;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0097421|liver regeneration;GO:1903492|response to acetylsalicylate;GO:1903861|positive regulation of dendrite extension;GO:1904692|positive regulation of type B pancreatic cell proliferation;GO:1904699|positive regulation of acinar cell proliferation;GO:1990785|response to water-immersion restraint stress;GO:1990798|pancreas regeneration;GO:1990864|response to growth hormone-releasing hormone;GO:1990867|response to gastrin;GO:1990869|cellular response to chemokine;GO:1990878|cellular response to gastrin;","GO:0005615|extracellular space;GO:0005829|cytosol;GO:0030426|growth cone;GO:0032590|dendrite membrane;GO:0032809|neuronal cell body membrane;GO:0032991|protein-containing complex;GO:0042588|zymogen granule;GO:0045178|basal part of cell;GO:0048471|perinuclear region of cytoplasm;","GO:0005102|signaling receptor binding;GO:0005515|protein binding;GO:0008083|growth factor activity;GO:0019902|phosphatase binding;GO:0019903|protein phosphatase binding;GO:0038023|signaling receptor activity;GO:0042802|identical protein binding;GO:0042834|peptidoglycan binding;GO:0070492|oligosaccharide binding;",".","."]
["ENSRNOG00000012022",0,0.042067634,10,0.643304382,0.065393048,-3.93471892,0.00377009,2.613644E-3,"down","yes","RGD1562914","protein_coding","chr8:51607763-51648628:-","gi|148693832|gb|EDL25779.1|",1277,{"v":3e-172,"d":"3.00E-172"},"mCG4182, partial [Mus musculus]","gi|672022802|ref|XM_008776709.1|",1058,0,"PREDICTED: Rattus norvegicus RGD1562914 (RGD1562914), mRNA",".",".",".",".",".",".",".",".","pfam04078","Rcd1","Cell differentiation family, Rcd1-like. Two of the members in this family have been characterized as being involved in regulation of Ste11 regulated sex genes. Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation.",".",".",".",".","."]
["ENSRNOG00000013062",0,0.042067634,10,0.643304382,0.065393048,-3.93471892,0.00377009,2.613644E-3,"down","yes","Cyp24a1","protein_coding","chr3:159275947-159290383:-","gi|42761472|ref|NP_963966.1|",2756,0,"1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial precursor [Rattus norvegicus]","gi|71682172|gb|BC100059.1|",3212,0,"Rattus norvegicus cytochrome P450, subfamily 24, mRNA (cDNA clone MGC:112576 IMAGE:7129117), complete cds","Q09128",1066,0,"1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial","BH0579",129,{"v":9e-31,"d":"9.00E-31"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0001649|osteoblast differentiation;GO:0010430|fatty acid omega-oxidation;GO:0033280|response to vitamin D;GO:0042359|vitamin D metabolic process;GO:0042369|vitamin D catabolic process;","GO:0005654|nucleoplasm;GO:0005739|mitochondrion;","GO:0005506|iron ion binding;GO:0008403|25-hydroxycholecalciferol-24-hydroxylase activity;GO:0020037|heme binding;GO:0030342|1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity;GO:0070576|vitamin D 24-hydroxylase activity;GO:0070643|vitamin D 25-hydroxylase activity;","K07436","CYP24A1; vitamin D3 24-hydroxylase [EC:1.14.15.16]"]
["ENSRNOG00000013222",0,0.042067634,10,0.643304382,0.065393048,-3.93471892,0.00377009,2.613644E-3,"down","yes","Cd207","protein_coding","chr4:116155212-116161518:-","gi|392340083|ref|XP_002726471.2|",1794,0,"PREDICTED: C-type lectin domain family 4 member K [Rattus norvegicus]","gi|672018474|ref|XM_002726425.4|",1469,0,"PREDICTED: Rattus norvegicus CD207 molecule, langerin (Cd207), mRNA","Q8VBX4",613,0,"C-type lectin domain family 4 member K",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0051607|defense response to virus;","GO:0016021|integral component of membrane;","GO:0030246|carbohydrate binding;","K06561","CD207; CD207 antigen"]
["ENSRNOG00000017725",0,0.042067634,10,0.643304382,0.065393048,-3.93471892,0.00377009,2.613644E-3,"down","yes","Pnlip","protein_coding","chr1:257798581-257811654:+","gi|149040500|gb|EDL94538.1|",2514,0,"pancreatic lipase, isoform CRA_a [Rattus norvegicus]","gi|402692544|ref|NM_013161.2|",1439,0,"Rattus norvegicus pancreatic lipase (Pnlip), mRNA","P27657",967,0,"Pancreatic triacylglycerol lipase",".",".",".",".","pfam00151","Lipase","Lipase.","GO:0006629|lipid metabolic process;GO:0009791|post-embryonic development;GO:0016042|lipid catabolic process;GO:0030299|intestinal cholesterol absorption;GO:0033993|response to lipid;GO:0042572|retinol metabolic process;GO:0043434|response to peptide hormone;GO:0061365|positive regulation of triglyceride lipase activity;","GO:0005615|extracellular space;","GO:0004806|triglyceride lipase activity;GO:0016298|lipase activity;GO:0046872|metal ion binding;GO:0047376|all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity;","K14073","PNLIP, PL; pancreatic triacylglycerol lipase [EC:3.1.1.3]"]
["ENSRNOG00000026371",0,0.042067634,10,0.643304382,0.065393048,-3.93471892,0.00377009,2.613644E-3,"down","yes","Krt17","protein_coding","chr10:85178675-85183392:-","gi|47087085|ref|NP_997710.1|",1671,0,"keratin, type I cytoskeletal 17 [Rattus norvegicus]","gi|71896558|ref|NM_212545.2|",1260,0,"Rattus norvegicus keratin 17, type I (Krt17), mRNA","Q6IFU8",645,0,"Keratin, type I cytoskeletal 17",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0002009|morphogenesis of an epithelium;GO:0030307|positive regulation of cell growth;GO:0031069|hair follicle morphogenesis;GO:0031424|keratinization;GO:0045103|intermediate filament-based process;GO:0045109|intermediate filament organization;GO:0045727|positive regulation of translation;GO:0051798|positive regulation of hair follicle development;","GO:0005737|cytoplasm;GO:0005882|intermediate filament;GO:0045095|keratin filament;GO:0045111|intermediate filament cytoskeleton;GO:0071944|cell periphery;","GO:0005198|structural molecule activity;GO:0005200|structural constituent of cytoskeleton;","K07604","KRT1; type I keratin, acidic"]
["ENSRNOG00000027821",0,0.042067634,10,0.643304382,0.065393048,-3.93471892,0.00377009,2.613644E-3,"down","yes","Lcn9","protein_coding","chr3:8636548-8652200:+","gi|672044786|ref|XP_008759844.1|",765,{"v":2e-96,"d":"2.00E-96"},"PREDICTED: epididymal-specific lipocalin-9 isoform X1 [Rattus norvegicus]","gi|108947877|gb|DQ537496.1|",427,0,"Rattus norvegicus lipocalin 9 (Lcn9) mRNA, complete cds","Q9D267",232,{"v":2e-72,"d":"2.00E-72"},"Epididymal-specific lipocalin-9",".",".",".",".","pfam00061","Lipocalin","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.",".","GO:0005615|extracellular space;","GO:0005550|pheromone binding;GO:0036094|small molecule binding;",".","."]
["ENSRNOG00000028095",0,0.042067634,10,0.643304382,0.065393048,-3.93471892,0.00377009,2.613644E-3,"down","yes","Lcn6","protein_coding","chr3:8484013-8489574:+","gi|48040593|ref|NP_001001519.1|",899,{"v":4e-120,"d":"4.00E-120"},"epididymal-specific lipocalin-6 precursor [Rattus norvegicus]","gi|48040592|ref|NM_001001519.1|",724,0,"Rattus norvegicus lipocalin 6 (Lcn6), mRNA","P62503",270,{"v":4E-90,"d":"4.00E-90"},"Epididymal-specific lipocalin-6",".",".",".",".","pfam00061","Lipocalin","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.",".","GO:0005576|extracellular region;","GO:0036094|small molecule binding;",".","."]
["ENSRNOG00000029591",0,0.042067634,10,0.643304382,0.065393048,-3.93471892,0.00377009,2.613644E-3,"down","yes","Pkdrej","protein_coding","chr7:116909094-116915468:-","gi|198442901|ref|NP_001128338.1|",10759,0,"polycystic kidney disease and receptor for egg jelly-related protein precursor [Rattus norvegicus]","gi|198442900|ref|NM_001134866.1|",6375,0,"Rattus norvegicus polycystin (PKD) family receptor for egg jelly (Pkdrej), mRNA","Q9Z0T6",3396,0,"Polycystic kidney disease and receptor for egg jelly-related protein",".",".",".",".","pfam08016","PKD_channel","Polycystin cation channel. This family contains the cation channel region of PKD1 and PKD2 proteins.","GO:0050982|detection of mechanical stimulus;GO:0060046|regulation of acrosome reaction;GO:0070588|calcium ion transmembrane transport;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0005262|calcium channel activity;GO:0005509|calcium ion binding;","K19921","PKDREJ; polycystic kidney disease and receptor for egg jelly-related protein"]
["ENSRNOG00000037203",0,0.042067634,10,0.643304382,0.065393048,-3.93471892,0.00377009,2.613644E-3,"down","yes","Tgm7","protein_coding","chr3:108051890-108076239:-","gi|672017438|ref|XP_008773757.1|",3691,0,"PREDICTED: protein-glutamine gamma-glutamyltransferase Z, partial [Rattus norvegicus]","gi|672017437|ref|XM_008775535.1|",2324,0,"PREDICTED: Rattus norvegicus protein-glutamine gamma-glutamyltransferase Z-like (LOC102552199), partial mRNA","Q96PF1",1148,0,"Protein-glutamine gamma-glutamyltransferase Z",".",".",".",".","pfam00868","Transglut_N","Transglutaminase family.",".",".","GO:0046872|metal ion binding;","K05623","TGM7; transglutaminase 7 [EC:2.3.2.13]"]
["ENSRNOG00000050840",0,0.042067634,10,0.643304382,0.065393048,-3.93471892,0.00377009,2.613644E-3,"down","yes","Mir155","miRNA","chr11:23774654-23774718:+",".",".",".",".","gi|827342590|ref|NR_132107.1|",65,{"v":8e-25,"d":"8.00E-25"},"Rattus norvegicus Mir155 host gene (Mir155hg), long non-coding RNA",".",".",".",".",".",".",".",".","pfam11872","DUF3392","Protein of unknown function (DUF3392). This family of proteins are functionally uncharacterized. This protein is found in bacteria. Proteins in this family are about 110 amino acids in length.","GO:0002437|inflammatory response to antigenic stimulus;GO:0010629|negative regulation of gene expression;GO:0030307|positive regulation of cell growth;GO:0032729|positive regulation of interferon-gamma production;GO:0035195|gene silencing by miRNA;GO:0060218|hematopoietic stem cell differentiation;GO:0070482|response to oxygen levels;GO:0071222|cellular response to lipopolysaccharide;GO:0071230|cellular response to amino acid stimulus;GO:0071354|cellular response to interleukin-6;GO:0071549|cellular response to dexamethasone stimulus;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0097011|cellular response to granulocyte macrophage colony-stimulating factor stimulus;",".",".","K17009","MIR155; microRNA 155"]
["ENSRNOG00000058009",0,0.042067634,10,0.643304382,0.065393048,-3.93471892,0.00377009,2.613644E-3,"down","yes","SNORA70","snoRNA","chr11:44586288-44586425:+","gi|664730342|ref|XP_008522378.1|",120,3e-07,"PREDICTED: 60S ribosomal protein L10-like [Equus przewalskii]","gi|589968209|ref|XM_006996537.1|",118,{"v":8e-54,"d":"8.00E-54"},"PREDICTED: Peromyscus maniculatus bairdii tRNA methyltransferase 10 homolog C (S. cerevisiae) (Trmt10c), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam00777","Glyco_transf_29","Glycosyltransferase family 29 (sialyltransferase). Members of this family belong to glycosyltransferase family 29.",".",".",".",".","."]
["ENSRNOG00000013704",6,0.504811612,25,1.608260955,0.31388663,-1.671684514,0.003973011,2.741753E-3,"down","yes","Cps1","protein_coding","chr9:68614153-68737033:+","gi|8393186|ref|NP_058768.1|",7924,0,"carbamoyl-phosphate synthase [ammonia], mitochondrial precursor [Rattus norvegicus]","gi|8393185|ref|NM_017072.1|",4503,0,"Rattus norvegicus carbamoyl-phosphate synthase 1 (Cps1), mRNA","P07756",3056,0,"Carbamoyl-phosphate synthase [ammonia], mitochondrial","SPAC22G7.06c_2",1132,0,"COG0458","pfam02786","CPSase_L_D2","Carbamoyl-phosphate synthase L chain, ATP binding domain. Carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from glutamine or ammonia and bicarbonate. This important enzyme initiates both the urea cycle and the biosynthesis of arginine and/or pyrimidines. The carbamoyl-phosphate synthase (CPS) enzyme in prokaryotes is a heterodimer of a small and large chain. The small chain promotes the hydrolysis of glutamine to ammonia, which is used by the large chain to synthesize carbamoyl phosphate. See pfam00988. The small chain has a GATase domain in the carboxyl terminus. See pfam00117. The ATP binding domain (this one) has an ATP-grasp fold.","GO:0000050|urea cycle;GO:0001889|liver development;GO:0006207|'de novo' pyrimidine nucleobase biosynthetic process;GO:0006508|proteolysis;GO:0006541|glutamine metabolic process;GO:0006807|nitrogen compound metabolic process;GO:0007494|midgut development;GO:0009410|response to xenobiotic stimulus;GO:0009636|response to toxic substance;GO:0010043|response to zinc ion;GO:0014075|response to amine;GO:0019433|triglyceride catabolic process;GO:0032094|response to food;GO:0032496|response to lipopolysaccharide;GO:0033762|response to glucagon;GO:0034201|response to oleic acid;GO:0042311|vasodilation;GO:0042594|response to starvation;GO:0043200|response to amino acid;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0046209|nitric oxide metabolic process;GO:0048545|response to steroid hormone;GO:0050667|homocysteine metabolic process;GO:0051384|response to glucocorticoid;GO:0051591|response to cAMP;GO:0055081|anion homeostasis;GO:0060416|response to growth hormone;GO:0070365|hepatocyte differentiation;GO:0070409|carbamoyl phosphate biosynthetic process;GO:0071242|cellular response to ammonium ion;GO:0071320|cellular response to cAMP;GO:0071377|cellular response to glucagon stimulus;GO:0071400|cellular response to oleic acid;GO:0071548|response to dexamethasone;","GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0032991|protein-containing complex;GO:0042645|mitochondrial nucleoid;","GO:0004087|carbamoyl-phosphate synthase (ammonia) activity;GO:0004088|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity;GO:0004175|endopeptidase activity;GO:0005509|calcium ion binding;GO:0005524|ATP binding;GO:0005543|phospholipid binding;GO:0016595|glutamate binding;GO:0044877|protein-containing complex binding;GO:0072341|modified amino acid binding;","K01948","CPS1; carbamoyl-phosphate synthase (ammonia) [EC:6.3.4.16]"]
["ENSRNOG00000021381",6,0.504811612,25,1.608260955,0.31388663,-1.671684514,0.003973011,2.741753E-3,"down","yes","Ccdc68","protein_coding","chr18:63541896-63584119:+","gi|149064570|gb|EDM14773.1|",1572,0,"similar to CTCL tumor antigen se57-1 (predicted), isoform CRA_b [Rattus norvegicus]","gi|755561085|ref|XM_006526071.2|",919,0,"PREDICTED: Mus musculus coiled-coil domain containing 68 (Ccdc68), transcript variant X2, mRNA","Q8BVC4",496,{"v":3e-172,"d":"3.00E-172"},"Coiled-coil domain-containing protein 68",".",".",".",".","pfam15619","Lebercilin","Ciliary protein causing Leber congenital amaurosis disease. Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.","GO:0008104|protein localization;GO:0034454|microtubule anchoring at centrosome;GO:0035556|intracellular signal transduction;","GO:0005622|intracellular;GO:0005814|centriole;GO:0120103|centriolar subdistal appendage;",".","K25398","CCDC68; coiled-coil domain containing protein 68"]
["ENSRNOG00000021796",6,0.504811612,25,1.608260955,0.31388663,-1.671684514,0.003973011,2.741753E-3,"down","yes","RGD1565166","protein_coding","chr10:10361948-10371046:+","gi|157786582|ref|NP_001099232.1|",1865,0,"UPF0764 protein C16orf89 homolog precursor [Rattus norvegicus]","gi|157786581|ref|NM_001105762.1|",1529,0,"Rattus norvegicus similar to MGC45438 protein (RGD1565166), mRNA","Q3UST5",647,0,"UPF0764 protein C16orf89 homolog",".",".",".",".",".",".",".",".","GO:0005829|cytosol;GO:0016020|membrane;","GO:0042803|protein homodimerization activity;",".","."]
["ENSRNOG00000057256",6,0.504811612,25,1.608260955,0.31388663,-1.671684514,0.003973011,2.741753E-3,"down","yes","Slc19a3","protein_coding","chr9:84277024-84299337:-","gi|157822875|ref|NP_001101698.1|",2539,0,"thiamine transporter 2 [Rattus norvegicus]","gi|157822874|ref|NM_001108228.1|",1579,0,"Rattus norvegicus solute carrier family 19 member 3 (Slc19a3), mRNA","Q99PL8",859,0,"Thiamine transporter 2",".",".",".",".","pfam01770","Folate_carrier","Reduced folate carrier. The reduced folate carrier (a transmembrane glycoprotein) transports reduced folate into mammalian cells via the carrier mediated mechanism (as opposed to the receptor mediated mechanism) it also transports cytotoxic folate analogues used in chemotherapy, such as methotrexate (MTX). Mammalian cells have an absolute requirement for exogenous folates which are needed for growth, and biosynthesis of macromolecules.","GO:0055085|transmembrane transport;GO:0071934|thiamine transmembrane transport;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0015234|thiamine transmembrane transporter activity;","K14610","SLC19A2_3, THTR; solute carrier family 19 (thiamine transporter), member 2/3"]
["ENSRNOG00000003544",21,1.766840642,55,3.5381741,0.499365094,-1.001833116,0.004034902,0.002780587,"down","yes","Tbx4","protein_coding","chr10:70731163-70760825:+","gi|157820223|ref|NP_001100504.1|",2946,0,"T-box transcription factor TBX4 [Rattus norvegicus]","gi|157820222|ref|NM_001107034.1|",3254,0,"Rattus norvegicus T-box 4 (Tbx4), mRNA","P70325",1105,0,"T-box transcription factor TBX4",".",".",".",".","pfam00907","T-box","T-box. The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.","GO:0001525|angiogenesis;GO:0001708|cell fate specification;GO:0002009|morphogenesis of an epithelium;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008150|biological_process;GO:0030324|lung development;GO:0030326|embryonic limb morphogenesis;GO:0035108|limb morphogenesis;GO:0035116|embryonic hindlimb morphogenesis;GO:0048705|skeletal system morphogenesis;GO:1990401|embryonic lung development;","GO:0005575|cellular_component;GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003674|molecular_function;","K10178","TBX4; T-box protein 4"]
["ENSRNOG00000047860",20,1.682705373,53,3.409513224,0.493532438,-1.018783185,0.004209855,0.002893828,"down","yes","Plin5","protein_coding","chr9:939747-946120:-","gi|197385053|ref|NP_001128109.1|",2495,0,"perilipin-5 [Rattus norvegicus]","gi|197385052|ref|NM_001134637.1|",1934,0,"Rattus norvegicus perilipin 5 (Plin5), mRNA","M0R7Z9",965,0,"Perilipin-5",".",".",".",".","pfam03036","Perilipin","Perilipin family. The perilipin family includes lipid droplet-associated protein (perilipin) and adipose differentiation-related protein (adipophilin).","GO:0010867|positive regulation of triglyceride biosynthetic process;GO:0010884|positive regulation of lipid storage;GO:0010890|positive regulation of sequestering of triglyceride;GO:0010897|negative regulation of triglyceride catabolic process;GO:0019915|lipid storage;GO:0031999|negative regulation of fatty acid beta-oxidation;GO:0032000|positive regulation of fatty acid beta-oxidation;GO:0034389|lipid droplet organization;GO:0035359|negative regulation of peroxisome proliferator activated receptor signaling pathway;GO:0050995|negative regulation of lipid catabolic process;GO:0051646|mitochondrion localization;GO:0060192|negative regulation of lipase activity;GO:0060193|positive regulation of lipase activity;GO:2000378|negative regulation of reactive oxygen species metabolic process;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005811|lipid droplet;GO:0005829|cytosol;GO:0043231|intracellular membrane-bounded organelle;","GO:0005515|protein binding;GO:0035473|lipase binding;GO:0042802|identical protein binding;","K20255","PLIN5; perilipin-5"]
["ENSRNOG00000033010",19,1.598570104,51,3.280852347,0.487242318,-1.037288654,0.004381303,0.002998808,"down","yes","Akr1c12","protein_coding","chr17:66045378-66108329:-","gi|148230802|ref|NP_001014262.3|",1726,0,"aldo-keto reductase family 1, member C13 [Rattus norvegicus]","gi|33187770|gb|AY327508.1|",1221,0,"Rattus norvegicus liver regeneration-related protein LRRG07 mRNA, complete cds","Q8VC28",598,0,"Aldo-keto reductase family 1 member C13","YOR120w",194,{"v":1e-55,"d":"1.00E-55"},"COG0656","pfam00248","Aldo_ket_red","Aldo/keto reductase family. This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.","GO:0008202|steroid metabolic process;","GO:0005829|cytosol;","GO:0004032|alditol:NADP+ 1-oxidoreductase activity;GO:0016229|steroid dehydrogenase activity;GO:0047086|ketosteroid monooxygenase activity;GO:0047834|D-threo-aldose 1-dehydrogenase activity;",".","."]
["ENSRNOG00000064970",19,1.598570104,51,3.280852347,0.487242318,-1.037288654,0.004381303,0.002998808,"down","yes","Zfp939","protein_coding","chr1:91128294-91140943:+","gi|564297297|ref|XP_006223276.1|",2972,0,"PREDICTED: zinc finger protein OZF-like isoform X1 [Rattus norvegicus]","gi|672036623|ref|XM_006228931.2|",2587,0,"PREDICTED: Rattus norvegicus zinc finger protein 939 (Zfp939), transcript variant X1, mRNA","Q96RE9",469,{"v":2E-149,"d":"2.00E-149"},"Zinc finger protein 300",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000016749",4,0.336541075,20,1.286608764,0.261572192,-1.93471892,0.004389491,0.00300328,"down","yes","Klhl10","protein_coding","chr10:85376442-85392720:+","gi|395826410|ref|XP_003786411.1|",3445,0,"PREDICTED: kelch-like protein 10 isoform X1 [Otolemur garnettii]","gi|48040498|ref|NM_001001510.1|",2009,0,"Rattus norvegicus kelch-like family member 10 (Klhl10), mRNA","Q6JEL3",1276,0,"Kelch-like protein 10",".",".",".",".","pfam07707","BACK","BTB And C-terminal Kelch. This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).","GO:0000902|cell morphogenesis;GO:0007286|spermatid development;GO:0008584|male gonad development;GO:0009566|fertilization;GO:0016567|protein ubiquitination;GO:0048808|male genitalia morphogenesis;GO:0048873|homeostasis of number of cells within a tissue;","GO:0005737|cytoplasm;",".","K10448","KLHL10; kelch-like protein 10"]
["ENSRNOG00000037360",4,0.336541075,20,1.286608764,0.261572192,-1.93471892,0.004389491,0.00300328,"down","yes","AABR07003173.1","pseudogene","chr1:93016530-93017532:-","gi|589962265|ref|XP_006993691.1|",748,{"v":3e-95,"d":"3.00E-95"},"PREDICTED: growth factor receptor-bound protein 2 isoform X1 [Peromyscus maniculatus bairdii]","gi|914958|dbj|D49848.1|RATASHPSI",1001,0,"Rattus norvegicus mRNA for Ash-psi, complete cds","P62994",291,{"v":3e-96,"d":"3.00E-96"},"Growth factor receptor-bound protein 2",".",".",".",".","pfam00018","SH3_1","SH3 domain. SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta barrel.",".",".",".",".","."]
["ENSRNOG00000014971",7,0.588946881,27,1.736921831,0.339075064,-1.560323405,0.004394943,0.0030055,"down","yes","Mas1","protein_coding","chr1:47880309-47911709:+","gi|6981186|ref|NP_036889.1|",1574,0,"proto-oncogene Mas [Rattus norvegicus]","gi|672034271|ref|XM_006227860.2|",1879,0,"PREDICTED: Rattus norvegicus MAS1 proto-oncogene, G protein-coupled receptor (Mas1), transcript variant X1, mRNA","P12526",610,0,"Proto-oncogene Mas",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001933|negative regulation of protein phosphorylation;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007250|activation of NF-kappaB-inducing kinase activity;GO:0007283|spermatogenesis;GO:0008284|positive regulation of cell proliferation;GO:0008584|male gonad development;GO:0009410|response to xenobiotic stimulus;GO:0014823|response to activity;GO:0021766|hippocampus development;GO:0034698|response to gonadotropin;GO:0038166|angiotensin-activated signaling pathway;GO:0043434|response to peptide hormone;GO:0045740|positive regulation of DNA replication;GO:0050727|regulation of inflammatory response;GO:0060732|positive regulation of inositol phosphate biosynthetic process;GO:0070528|protein kinase C signaling;GO:0071375|cellular response to peptide hormone stimulus;","GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0001595|angiotensin receptor activity;GO:0004930|G protein-coupled receptor activity;GO:0042277|peptide binding;","K04303","MAS1; proto-oncogene Mas"]
["ENSRNOG00000063882",7,0.588946881,27,1.736921831,0.339075064,-1.560323405,0.004394943,0.0030055,"down","yes","ENSRNOG00000063882","lncRNA","chr8:48556254-48560810:-",".",".",".",".","gi|67906393|gb|AC154373.2|",105,{"v":5e-46,"d":"5.00E-46"},"Mus musculus BAC clone RP23-79I18 from chromosome 9, complete sequence",".",".",".",".",".",".",".",".","pfam13622","4HBT_3","Thioesterase-like superfamily. This family contains a wide variety of enzymes, principally thioesterases. These enzymes are part of the Hotdog fold superfamily.",".",".",".",".","."]
["ENSRNOG00000067637",7,0.588946881,27,1.736921831,0.339075064,-1.560323405,0.004394943,0.0030055,"down","yes","ENSRNOG00000067637","lncRNA","chr1:183318398-183320897:-",".",".",".",".","gi|354794353|gb|JN958854.1|",133,{"v":4e-61,"d":"4.00E-61"},"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Sec23ip:tm1e(EUCOMM)Hmgu; transgenic",".",".",".",".",".",".",".",".","pfam11996","DUF3491","Protein of unknown function (DUF3491). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 286 to 3225 amino acids in length. This protein is found associated with pfam04488. This protein is found associated with pfam04488.",".",".",".",".","."]
["ENSRNOG00000068246",7,0.588946881,27,1.736921831,0.339075064,-1.560323405,0.004394943,0.0030055,"down","yes","ENSRNOG00000068246","lncRNA","chr3:18372888-18387230:+","gi|149054000|gb|EDM05817.1|",172,{"v":1e-12,"d":"1.00E-12"},"rCG33163 [Rattus norvegicus]","gi|672016645|ref|XR_600126.1|",515,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103691771 (LOC103691771), ncRNA",".",".",".",".",".",".",".",".","pfam02093","Gag_p30","Gag P30 core shell protein. According to Swiss-Prot annotation this protein is the viral core shell protein. P30 is essential for viral assembly.",".",".",".",".","."]
["ENSRNOG00000028805",8,0.673082149,29,1.865582707,0.36078923,-1.47077182,0.004712821,0.00320197,"down","yes","Cfap77","protein_coding","chr3:12258453-12381319:-","gi|189011616|ref|NP_001121035.1|",1520,0,"uncharacterized protein C9orf171 homolog [Rattus norvegicus]","gi|189011615|ref|NM_001127563.1|",1707,0,"Rattus norvegicus cilia and flagella associated protein 77 (Cfap77), mRNA","Q6ZQR2",491,{"v":1E-169,"d":"1.00E-169"},"Cilia- and flagella-associated protein 77",".",".",".",".","pfam14825","DUF4483","Domain of unknown function (DUF4483). This family of proteins is found in eukaryotes. Proteins in this family are typically between 203 and 326 amino acids in length. There is a single completely conserved residue N that may be functionally important.",".",".",".",".","."]
["ENSRNOG00000034089",8,0.673082149,29,1.865582707,0.36078923,-1.47077182,0.004712821,0.00320197,"down","yes","Ttc21a","protein_coding","chr8:119666933-119702456:+","gi|392342139|ref|XP_003754513.1|",6777,0,"PREDICTED: tetratricopeptide repeat protein 21A isoform X1 [Rattus norvegicus]","gi|672063720|ref|XM_003750604.3|",5173,0,"PREDICTED: Rattus norvegicus tetratricopeptide repeat domain 21A (Ttc21a), transcript variant X1, mRNA","Q8C0S4",2460,0,"Tetratricopeptide repeat protein 21A",".",".",".",".","pfam14559","TPR_19","Tetratricopeptide repeat.","GO:0007286|spermatid development;GO:0030317|flagellated sperm motility;GO:0035721|intraciliary retrograde transport;GO:0061512|protein localization to cilium;","GO:0005929|cilium;GO:0030991|intraciliary transport particle A;",".","K24178","TTC21A, IFT139A; tetratricopeptide repeat protein 21A"]
["ENSRNOG00000065054",8,0.673082149,29,1.865582707,0.36078923,-1.47077182,0.004712821,0.00320197,"down","yes","Hist2h3c2","protein_coding","chr17:41378175-41378719:-","gi|564319879|ref|XP_006222460.1|",725,{"v":8e-95,"d":"8.00E-95"},"PREDICTED: histone H3-like [Rattus norvegicus]","gi|564319878|ref|XM_006222398.1|",472,0,"PREDICTED: Rattus norvegicus histone H3.2-like (LOC102549173), mRNA","P84239",273,{"v":8e-93,"d":"8.00E-93"},"Histone H3",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.",".",".",".",".","."]
["ENSRNOG00000012593",9,0.757217418,31,1.994243584,0.379701569,-1.397062134,0.004937181,0.003338158,"down","yes","Mmel1","protein_coding","chr5:165431343-165461716:+","gi|157819215|ref|NP_001101467.1|",4134,0,"membrane metallo-endopeptidase-like 1 [Rattus norvegicus]","gi|157819214|ref|NM_001107997.1|",2806,0,"Rattus norvegicus membrane metallo-endopeptidase-like 1 (Mmel1), mRNA","P0C1T0",1584,0,"Membrane metallo-endopeptidase-like 1","MA2001",323,{"v":1e-96,"d":"1.00E-96"},"COG3590","pfam05649","Peptidase_M13_N","Peptidase family M13. M13 peptidases are well-studied proteases found in a wide range of organisms including mammals and bacteria. In mammals they participate in processes such as cardiovascular development, blood-pressure regulation, nervous control of respiration, and regulation of the function of neuropeptides in the central nervous system. In bacteria they may be used for digestion of milk.","GO:0006508|proteolysis;GO:0008150|biological_process;GO:0016485|protein processing;","GO:0005615|extracellular space;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0004175|endopeptidase activity;GO:0004222|metalloendopeptidase activity;GO:0008270|zinc ion binding;GO:0046872|metal ion binding;","K08635","MMEL1, NEP; neprilysin [EC:3.4.24.11]"]
["ENSRNOG00000022723",9,0.757217418,31,1.994243584,0.379701569,-1.397062134,0.004937181,0.003338158,"down","yes","RGD1562029","protein_coding","chr9:60968310-61075626:+","gi|672024113|ref|XP_008756273.1|",3648,0,"PREDICTED: uncharacterized protein KIAA2012 homolog [Rattus norvegicus]","gi|672024112|ref|XM_008758051.1|",2127,0,"PREDICTED: Rattus norvegicus similar to KIAA2012 protein (RGD1562029), mRNA",".",".",".",".",".",".",".",".","pfam06728","PIG-U","GPI transamidase subunit PIG-U. Many eukaryotic proteins are anchored to the cell surface via glycosylphosphatidylinositol (GPI), which is posttranslationally attached to the carboxyl-terminus by GPI transamidase. The mammalian GPI transamidase is a complex of at least four subunits, GPI8, GAA1, PIG-S, and PIG-T. PIG-U is thought to represent a fifth subunit in this complex and may be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.",".",".",".",".","."]
["ENSRNOG00000046264",9,0.757217418,31,1.994243584,0.379701569,-1.397062134,0.004937181,0.003338158,"down","yes","Pcdhb7","protein_coding","chr18:29054745-29057644:+","gi|392334116|ref|XP_003753085.1|",3995,0,"PREDICTED: protocadherin beta-4 [Rattus norvegicus]","gi|672030600|ref|XM_003753037.3|",2482,0,"PREDICTED: Rattus norvegicus protocadherin beta 7 (Pcdhb7), mRNA","Q5DRD0",1188,0,"Protocadherin beta-4",".",".",".",".","pfam08266","Cadherin_2","Cadherin-like. This cadherin domain is usually the most N-terminal copy of the domain.","GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;",".","GO:0005509|calcium ion binding;","K16494","PCDHB; protocadherin beta"]
["ENSRNOG00000070093",9,0.757217418,31,1.994243584,0.379701569,-1.397062134,0.004937181,0.003338158,"down","yes","ENSRNOG00000070093","lncRNA","chr14:78048312-78055698:-",".",".",".",".","gi|40841710|gb|AC094950.6|",469,0,"Rattus norvegicus 14 BAC CH230-6H12 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam07509","DUF1523","Protein of unknown function (DUF1523).",".",".",".",".","."]
["ENSRNOG00000002381",15,1.26202903,43,2.766208842,0.456230567,-1.132164984,0.004968745,0.003357832,"down","yes","Bmp3","protein_coding","chr14:10712489-10737153:-","gi|149046840|gb|EDL99614.1|",2434,0,"bone morphogenetic protein 3, isoform CRA_b [Rattus norvegicus]","gi|8392992|ref|NM_017105.1|",2140,0,"Rattus norvegicus bone morphogenetic protein 3 (Bmp3), mRNA","P49002",917,0,"Bone morphogenetic protein 3",".",".",".",".","pfam00019","TGF_beta","Transforming growth factor beta like domain.","GO:0001649|osteoblast differentiation;GO:0007165|signal transduction;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051216|cartilage development;GO:0060395|SMAD protein signal transduction;","GO:0005615|extracellular space;GO:0031982|vesicle;","GO:0005125|cytokine activity;GO:0008083|growth factor activity;GO:0070700|BMP receptor binding;","K05496","BMP3; bone morphogenetic protein 3"]
["ENSRNOG00000019339",14,1.177893761,41,2.637547966,0.446586669,-1.162987908,0.005069014,0.003417956,"down","yes","Ttll11","protein_coding","chr3:19110284-19335969:-","gi|392346263|ref|XP_001071863.3|",3596,0,"PREDICTED: tubulin polyglutamylase TTLL11 isoform X3 [Rattus norvegicus]","gi|672045460|ref|XM_001071863.5|",2101,0,"PREDICTED: Rattus norvegicus tubulin tyrosine ligase-like family, member 11 (Ttll11), transcript variant X3, mRNA","A4Q9F4",1228,0,"Tubulin polyglutamylase TTLL11",".",".",".",".","pfam03133","TTL","Tubulin-tyrosine ligase family. Tubulins and microtubules are subjected to several post-translational modifications of which the reversible detyrosination/tyrosination of the carboxy-terminal end of most alpha-tubulins has been extensively analysed. This modification cycle involves a specific carboxypeptidase and the activity of the tubulin-tyrosine ligase (TTL). The true physiological function of TTL has so far not been established. Tubulin-tyrosine ligase (TTL) catalyses the ATP-dependent post-translational addition of a tyrosine to the carboxy terminal end of detyrosinated alpha-tubulin. In normally cycling cells, the tyrosinated form of tubulin predominates. However, in breast cancer cells, the detyrosinated form frequently predominates, with a correlation to tumor aggressiveness. On the other hand, 3-nitrotyrosine has been shown to be incorporated, by TTL, into the carboxy terminal end of detyrosinated alpha-tubulin. This reaction is not reversible by the carboxypeptidase enzyme. Cells cultured in 3-nitrotyrosine rich medium showed evidence of altered microtubule structure and function, including altered cell morphology, epithelial barrier dysfunction, and apoptosis. Bacterial homologs of TTL are predicted to form peptide tags. Some of these are fused to a 2-oxoglutarate Fe(II)-dependent dioxygenase domain.","GO:0018095|protein polyglutamylation;GO:0051013|microtubule severing;","GO:0036064|ciliary basal body;",".","K16604","TTLL11; tubulin polyglutamylase TTLL11 [EC:6.3.2.-]"]
["ENSRNOG00000063781",14,1.177893761,41,2.637547966,0.446586669,-1.162987908,0.005069014,0.003417956,"down","yes","ENSRNOG00000063781","protein_coding","chr5:127376764-127398397:+","gi|300797222|ref|NP_001178499.1|",1849,0,"ankyrin repeat domain-containing protein 13C [Rattus norvegicus]","gi|672053518|ref|XM_008763971.1|",1927,0,"PREDICTED: Rattus norvegicus ankyrin repeat domain-containing protein 13C-like (LOC102548397), transcript variant X2, mRNA","Q3UX43",701,0,"Ankyrin repeat domain-containing protein 13C",".",".",".",".","pfam11904","GPCR_chapero_1","GPCR-chaperone. This domain, and the associated ANK family repeat pfam00023 domain, together act as a chaperone for biogenesis and folding of the DP receptor for prostaglandin D2.",".",".",".",".","."]
["ENSRNOG00000011141",10,0.841352686,33,2.12290446,0.396321503,-1.33525685,0.005080175,0.003423787,"down","yes","Serpina11","protein_coding","chr6:122903250-122912670:-","gi|261599054|ref|NP_001159824.1|",2089,0,"serpin A11 isoform 2 precursor [Rattus norvegicus]","gi|261599053|ref|NM_001166352.1|",1463,0,"Rattus norvegicus serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 (Serpina11), transcript variant 2, mRNA","Q7TPA5",810,0,"Serpin A11","all0778",139,{"v":1E-35,"d":"1.00E-35"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0010951|negative regulation of endopeptidase activity;","GO:0005615|extracellular space;","GO:0004867|serine-type endopeptidase inhibitor activity;","K04525","SERPINA; serpin A"]
["ENSRNOG00000047545",10,0.841352686,33,2.12290446,0.396321503,-1.33525685,0.005080175,0.003423787,"down","yes","Adra2a","protein_coding","chr1:253060218-253064365:+","gi|340805866|ref|NP_036871.3|",2136,0,"alpha-2A adrenergic receptor [Rattus norvegicus]","gi|340805865|ref|NM_012739.3|",2801,0,"Rattus norvegicus adrenoceptor alpha 2A (Adra2a), mRNA","P22909",796,0,"Alpha-2A adrenergic receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001819|positive regulation of cytokine production;GO:0002526|acute inflammatory response;GO:0006260|DNA replication;GO:0007165|signal transduction;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007193|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007565|female pregnancy;GO:0019229|regulation of vasoconstriction;GO:0030168|platelet activation;GO:0030335|positive regulation of cell migration;GO:0032147|activation of protein kinase activity;GO:0032148|activation of protein kinase B activity;GO:0032870|cellular response to hormone stimulus;GO:0035624|receptor transactivation;GO:0042311|vasodilation;GO:0042593|glucose homeostasis;GO:0042596|fear response;GO:0043268|positive regulation of potassium ion transport;GO:0043406|positive regulation of MAP kinase activity;GO:0043410|positive regulation of MAPK cascade;GO:0045741|positive regulation of epidermal growth factor-activated receptor activity;GO:0045955|negative regulation of calcium ion-dependent exocytosis;GO:0046676|negative regulation of insulin secretion;GO:0050955|thermoception;GO:0050995|negative regulation of lipid catabolic process;GO:0051044|positive regulation of membrane protein ectodomain proteolysis;GO:0051926|negative regulation of calcium ion transport;GO:0061179|negative regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0070473|negative regulation of uterine smooth muscle contraction;GO:0071875|adrenergic receptor signaling pathway;GO:0071880|adenylate cyclase-activating adrenergic receptor signaling pathway;GO:0071881|adenylate cyclase-inhibiting adrenergic receptor signaling pathway;GO:0071882|phospholipase C-activating adrenergic receptor signaling pathway;GO:0090303|positive regulation of wound healing;GO:1901020|negative regulation of calcium ion transmembrane transporter activity;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0043025|neuronal cell body;GO:0043235|receptor complex;GO:0043679|axon terminus;GO:0045202|synapse;GO:0098691|dopaminergic synapse;GO:0098978|glutamatergic synapse;GO:0098982|GABA-ergic synapse;GO:0099055|integral component of postsynaptic membrane;GO:0099059|integral component of presynaptic active zone membrane;GO:0099061|integral component of postsynaptic density membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004935|adrenergic receptor activity;GO:0004938|alpha2-adrenergic receptor activity;GO:0019901|protein kinase binding;GO:0031692|alpha-1B adrenergic receptor binding;GO:0031696|alpha-2C adrenergic receptor binding;GO:0031996|thioesterase binding;GO:0032795|heterotrimeric G-protein binding;GO:0042803|protein homodimerization activity;GO:0046982|protein heterodimerization activity;GO:0051379|epinephrine binding;GO:0051380|norepinephrine binding;","K04138","ADRA2A; adrenergic receptor alpha-2A"]
["ENSRNOG00000064373",10,0.841352686,33,2.12290446,0.396321503,-1.33525685,0.005080175,0.003423787,"down","yes","NEWGENE_1309147","protein_coding","chr1:78880862-78913056:+","gi|148691179|gb|EDL23126.1|",633,{"v":1e-74,"d":"1.00E-74"},"optic atrophy 3 (human), isoform CRA_b [Mus musculus]","gi|755478440|ref|XM_006544143.2|",775,0,"PREDICTED: Mus musculus optic atrophy 3 protein-like (LOC102637572), mRNA","Q9H6K4",170,{"v":1e-47,"d":"1.00E-47"},"Optic atrophy 3 protein",".",".",".",".","pfam07047","OPA3","Optic atrophy 3 protein (OPA3). This family consists of several optic atrophy 3 (OPA3) proteins. OPA3 deficiency causes type III 3-methylglutaconic aciduria (MGA) in humans. This disease manifests with early bilateral optic atrophy, spasticity, extrapyramidal dysfunction, ataxia, and cognitive deficits, but normal longevity.",".",".",".",".","."]
["ENSRNOG00000043085",5,0.420676343,22,1.41526964,0.297241127,-1.750294349,0.005258776,0.003535564,"down","yes","Clstn2","protein_coding","chr8:98021666-98637731:-","gi|568961826|ref|XP_006511397.1|",4719,0,"PREDICTED: calsyntenin-2 isoform X1 [Mus musculus]","gi|672062821|ref|XM_008766475.1|",3647,0,"PREDICTED: Rattus norvegicus calsyntenin 2 (Clstn2), transcript variant X1, mRNA","Q8VDA1",1808,0,"Calsyntenin-2",".",".",".",".","pfam00028","Cadherin","Cadherin domain.","GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007268|chemical synaptic transmission;GO:0050806|positive regulation of synaptic transmission;GO:0051965|positive regulation of synapse assembly;","GO:0000139|Golgi membrane;GO:0005789|endoplasmic reticulum membrane;GO:0009986|cell surface;GO:0014069|postsynaptic density;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0042995|cell projection;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0098978|glutamatergic synapse;GO:0099061|integral component of postsynaptic density membrane;","GO:0005509|calcium ion binding;","K22660","CLSTN2; calsyntenin 2"]
["ENSRNOG00000046547",5,0.420676343,22,1.41526964,0.297241127,-1.750294349,0.005258776,0.003535564,"down","yes","Rbm24","protein_coding","chr17:18275688-18288102:-","gi|300797848|ref|NP_001178029.1|",937,{"v":9e-115,"d":"9.00E-115"},"RNA-binding protein 24 [Rattus norvegicus]","gi|300797847|ref|NM_001191100.1|",2604,0,"Rattus norvegicus RNA binding motif protein 24 (Rbm24), mRNA","D3Z4I3",362,{"v":3e-115,"d":"3.00E-115"},"RNA-binding protein 24","TP0356",60.5,1e-09,"COG0724","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0000381|regulation of alternative mRNA splicing, via spliceosome;GO:0003197|endocardial cushion development;GO:0006974|cellular response to DNA damage stimulus;GO:0010830|regulation of myotube differentiation;GO:0010831|positive regulation of myotube differentiation;GO:0043488|regulation of mRNA stability;GO:0048255|mRNA stabilization;GO:0061157|mRNA destabilization;GO:0061158|3'-UTR-mediated mRNA destabilization;GO:1902811|positive regulation of skeletal muscle fiber differentiation;GO:1905870|positive regulation of 3'-UTR-mediated mRNA stabilization;GO:2000738|positive regulation of stem cell differentiation;GO:2000766|negative regulation of cytoplasmic translation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0003730|mRNA 3'-UTR binding;GO:0035925|mRNA 3'-UTR AU-rich region binding;GO:0097157|pre-mRNA intronic binding;GO:1990715|mRNA CDS binding;GO:1990825|sequence-specific mRNA binding;","K25006","RBM24_38; RNA-binding protein 24/38"]
["ENSRNOG00000002164",3,0.252405806,17,1.093617449,0.230798993,-2.115291166,0.00538487,3.613036E-3,"down","yes","Nmu","protein_coding","chr14:31844728-31872192:+","gi|149035201|gb|EDL89905.1|",559,{"v":5e-68,"d":"5.00E-68"},"neuromedin U, isoform CRA_c [Rattus norvegicus]","gi|148747286|ref|NM_022239.2|",554,0,"Rattus norvegicus neuromedin U (Nmu), mRNA","P12760",208,{"v":1e-64,"d":"1.00E-64"},"Neuromedin-U",".",".",".",".","pfam02070","NMU","Neuromedin U.","GO:0001659|temperature homeostasis;GO:0001696|gastric acid secretion;GO:0003084|positive regulation of systemic arterial blood pressure;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007218|neuropeptide signaling pathway;GO:0009648|photoperiodism;GO:0010460|positive regulation of heart rate;GO:0019233|sensory perception of pain;GO:0031652|positive regulation of heat generation;GO:0042755|eating behavior;GO:0045187|regulation of circadian sleep/wake cycle, sleep;GO:0045987|positive regulation of smooth muscle contraction;GO:0046887|positive regulation of hormone secretion;GO:0050806|positive regulation of synaptic transmission;GO:0060259|regulation of feeding behavior;GO:0060455|negative regulation of gastric acid secretion;GO:0097009|energy homeostasis;GO:0120061|negative regulation of gastric emptying;GO:0120069|positive regulation of stomach fundus smooth muscle contraction;GO:1902722|positive regulation of prolactin secretion;GO:1903999|negative regulation of eating behavior;GO:1904058|positive regulation of sensory perception of pain;GO:2000252|negative regulation of feeding behavior;GO:2000821|regulation of grooming behavior;","GO:0005576|extracellular region;GO:0043195|terminal bouton;","GO:0031839|type 1 neuromedin U receptor binding;GO:0031840|type 2 neuromedin U receptor binding;GO:0042922|neuromedin U receptor binding;","K05249","NMU; neuromedin U"]
["ENSRNOG00000015566",3,0.252405806,17,1.093617449,0.230798993,-2.115291166,0.00538487,3.613036E-3,"down","yes","Atp6v1e2","protein_coding","chr6:7667564-7672626:+","gi|672055301|ref|XP_008762687.1|",983,{"v":1e-124,"d":"1.00E-124"},"PREDICTED: V-type proton ATPase subunit E 2 isoform X2 [Rattus norvegicus]","gi|157823018|ref|NM_001108979.1|",989,0,"Rattus norvegicus ATPase H+ transporting V1 subunit E2 (Atp6v1e2), mRNA","Q9D593",312,{"v":1E-99,"d":"1.00E-99"},"V-type proton ATPase subunit E 2","YOR332w",73.6,{"v":1E-13,"d":"1.00E-13"},"COG1390","pfam01991","vATP-synt_E","ATP synthase (E/31 kDa) subunit. This family includes the vacuolar ATP synthase E subunit, as well as the archaebacterial ATP synthase E subunit.","GO:1902600|proton transmembrane transport;","GO:0001669|acrosomal vesicle;GO:0033178|proton-transporting two-sector ATPase complex, catalytic domain;","GO:0046961|proton-transporting ATPase activity, rotational mechanism;","K02150","ATPeV1E, ATP6E; V-type H+-transporting ATPase subunit E"]
["ENSRNOG00000050602",3,0.252405806,17,1.093617449,0.230798993,-2.115291166,0.00538487,3.613036E-3,"down","yes","Kif28p","protein_coding","chr13:91427736-91482237:-","gi|393393850|ref|NP_001257314.1|",5134,0,"kinesin-like protein KIF28P [Rattus norvegicus]","gi|393393849|ref|NM_001270385.1|",3105,0,"Rattus norvegicus kinesin family member 28, pseudogene (Kif28p), mRNA","F8WLE0",1982,0,"Kinesin-like protein KIF28P","SPAC1834.07",211,{"v":2e-57,"d":"2.00E-57"},"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0007005|mitochondrion organization;GO:0007018|microtubule-based movement;GO:0072384|organelle transport along microtubule;","GO:0005871|kinesin complex;GO:0005874|microtubule;GO:0031966|mitochondrial membrane;","GO:0003777|microtubule motor activity;GO:0005524|ATP binding;GO:0008017|microtubule binding;GO:0016887|ATPase activity;",".","."]
["ENSRNOG00000064667",3,0.252405806,17,1.093617449,0.230798993,-2.115291166,0.00538487,3.613036E-3,"down","yes","Tmem86b","pseudogene","chr1:69218608-69220124:+","gi|564326271|ref|XP_006228351.1|",882,{"v":5E-117,"d":"5.00E-117"},"PREDICTED: lysoplasmalogenase isoform X1 [Rattus norvegicus]","gi|672035218|ref|XM_006228289.2|",591,0,"PREDICTED: Rattus norvegicus transmembrane protein 86B (Tmem86b), transcript variant X1, mRNA","B0BNF0",344,{"v":2E-118,"d":"2.00E-118"},"Lysoplasmalogenase",".",".",".",".","pfam07947","YhhN","YhhN-like protein. The members of this family are similar to the hypothetical protein yhhN expressed by Escherichia coli. Many of the members of this family are annotated as being possible transmembrane proteins, and in fact they all have a high proportion of hydrophobic residues.",".",".",".",".","."]
["ENSRNOG00000065832",3,0.252405806,17,1.093617449,0.230798993,-2.115291166,0.00538487,3.613036E-3,"down","yes","ENSRNOG00000065832","lncRNA","chr14:80688412-80691278:-","gi|148677466|gb|EDL09413.1|",154,{"v":1e-12,"d":"1.00E-12"},"mCG147326 [Mus musculus]","gi|56382171|gb|AC101277.16|",228,{"v":1e-113,"d":"1.00E-113"},"Mus musculus chromosome 1, clone RP23-101P2, complete sequence",".",".",".",".",".",".",".",".","pfam01867","Cas_Cas1","CRISPR associated protein Cas1. Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein. Cas1 may be involved in linking DNA segments to CRISPR.",".",".",".",".","."]
["ENSRNOG00000069551",3,0.252405806,17,1.093617449,0.230798993,-2.115291166,0.00538487,3.613036E-3,"down","yes","ENSRNOG00000069551","lncRNA","chr19:56703631-56704783:-","gi|564396440|ref|XP_006255905.1|",157,6E-9,"PREDICTED: collagen alpha-1(I) chain-like [Rattus norvegicus]","gi|70721514|gb|AC156608.10|",331,{"v":3E-171,"d":"3.00E-171"},"Mus musculus chromosome 8, clone RP23-303A11, complete sequence",".",".",".",".",".",".",".",".","pfam02517","Abi","CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.",".",".",".",".","."]
["ENSRNOG00000000373",19,1.598570104,50,3.216521909,0.496987165,-1.008719502,0.005830612,0.003886251,"down","yes","AABR07044900.1","protein_coding","chr20:23623560-25199978:-","gi|149043896|gb|EDL97347.1|",4259,0,"rCG61001 [Rattus norvegicus]","gi|256985120|ref|NM_001164376.1|",2466,0,"Mus musculus catenin (cadherin associated protein), alpha 3 (Ctnna3), transcript variant 1, mRNA","Q65CL1",1637,0,"Catenin alpha-3",".",".",".",".","pfam01044","Vinculin","Vinculin family.",".",".",".",".","."]
["ENSRNOG00000056716",19,1.598570104,50,3.216521909,0.496987165,-1.008719502,0.005830612,0.003886251,"down","yes","Zbtb20","protein_coding","chr11:57072880-57510210:-","gi|625187250|ref|XP_007617178.1|",3373,0,"PREDICTED: zinc finger and BTB domain-containing protein 20 isoform X2 [Cricetulus griseus]","gi|157786807|ref|NM_001105880.1|",5202,0,"Rattus norvegicus zinc finger and BTB domain containing 20 (Zbtb20), mRNA","Q8K0L9",1294,0,"Zinc finger and BTB domain-containing protein 20",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;GO:0010629|negative regulation of gene expression;GO:0032728|positive regulation of interferon-beta production;GO:0032755|positive regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0045821|positive regulation of glycolytic process;GO:0045892|negative regulation of transcription, DNA-templated;GO:0046889|positive regulation of lipid biosynthetic process;GO:0055088|lipid homeostasis;GO:0071333|cellular response to glucose stimulus;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0016604|nuclear body;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K10501","ZBTB20, HOF, DPZF; zinc finger and BTB domain-containing protein 20"]
["ENSRNOG00000000597",1,0.084135269,11,0.70763482,0.118896451,-3.072222444,0.005876139,0.003911807,"down","yes","Ccn6","protein_coding","chr20:42569309-42585126:-","gi|281427233|ref|NP_001163954.1|",1786,0,"WNT1-inducible-signaling pathway protein 3 precursor [Rattus norvegicus]","gi|281427232|ref|NM_001170483.1|",2509,0,"Rattus norvegicus WNT1 inducible signaling pathway protein 3 (Wisp3), mRNA","D3Z5L9",607,0,"WNT1-inducible-signaling pathway protein 3",".",".",".",".","pfam00219","IGFBP","Insulin-like growth factor binding protein.","GO:0007155|cell adhesion;GO:0007165|signal transduction;GO:0008150|biological_process;GO:0008285|negative regulation of cell proliferation;GO:0016525|negative regulation of angiogenesis;GO:0051881|regulation of mitochondrial membrane potential;GO:0060548|negative regulation of cell death;GO:1903426|regulation of reactive oxygen species biosynthetic process;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005739|mitochondrion;GO:0031012|extracellular matrix;","GO:0003674|molecular_function;GO:0005178|integrin binding;GO:0005520|insulin-like growth factor binding;GO:0008201|heparin binding;","K23090","CCN6, WISP3; CCN family member 6"]
["ENSRNOG00000008353",1,0.084135269,11,0.70763482,0.118896451,-3.072222444,0.005876139,0.003911807,"down","yes","Iqch","protein_coding","chr8:63892370-64083223:-","gi|672061925|ref|XP_008764459.1|",5587,0,"PREDICTED: IQ domain-containing protein H isoform X4 [Rattus norvegicus]","gi|672061924|ref|XM_008766237.1|",3444,0,"PREDICTED: Rattus norvegicus IQ motif containing H (Iqch), transcript variant X4, mRNA",".",".",".",".",".",".",".",".","pfam00612","IQ","IQ calmodulin-binding motif. Calmodulin-binding motif.",".",".",".","K24842","IQCH; IQ domain-containing protein H"]
["ENSRNOG00000011453",1,0.084135269,11,0.70763482,0.118896451,-3.072222444,0.005876139,0.003911807,"down","yes","Kif6","protein_coding","chr9:11072824-11373006:-","gi|564311103|ref|XP_006226768.1|",4108,0,"PREDICTED: kinesin-like protein KIF6 [Rattus norvegicus]","gi|564311102|ref|XM_006226706.1|",3349,0,"PREDICTED: Rattus norvegicus kinesin family member 6 (Kif6), mRNA","Q6ZMV9",1281,0,"Kinesin-like protein KIF6","SPAC1834.07",221,{"v":1e-60,"d":"1.00E-60"},"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0007018|microtubule-based movement;GO:0007286|spermatid development;","GO:0001673|male germ cell nucleus;GO:0005871|kinesin complex;GO:0005874|microtubule;","GO:0003777|microtubule motor activity;GO:0005524|ATP binding;GO:0008017|microtubule binding;GO:0016887|ATPase activity;","K10397","KIF6_9; kinesin family member 6/9"]
["ENSRNOG00000020990",1,0.084135269,11,0.70763482,0.118896451,-3.072222444,0.005876139,0.003911807,"down","yes","Fgf21","protein_coding","chr1:96083441-96090454:-","gi|18543365|ref|NP_570108.1|",807,{"v":3e-99,"d":"3.00E-99"},"fibroblast growth factor 21 precursor [Rattus norvegicus]","gi|88023877|gb|AC136191.5|",1616,0,"Rattus norvegicus BAC CH230-52I17 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q9JJN1",289,{"v":1e-90,"d":"1.00E-90"},"Fibroblast growth factor 21",".",".",".",".","pfam01531","Glyco_transf_11","Glycosyl transferase family 11. This family contains several fucosyl transferase enzymes.","GO:0001934|positive regulation of protein phosphorylation;GO:0008284|positive regulation of cell proliferation;GO:0008543|fibroblast growth factor receptor signaling pathway;GO:0009887|animal organ morphogenesis;GO:0010628|positive regulation of gene expression;GO:0010898|positive regulation of triglyceride catabolic process;GO:0014823|response to activity;GO:0030154|cell differentiation;GO:0030334|regulation of cell migration;GO:0030968|endoplasmic reticulum unfolded protein response;GO:0031667|response to nutrient levels;GO:0046326|positive regulation of glucose import;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071333|cellular response to glucose stimulus;GO:0071377|cellular response to glucagon stimulus;GO:0071404|cellular response to low-density lipoprotein particle stimulus;GO:0071466|cellular response to xenobiotic stimulus;GO:0072577|endothelial cell apoptotic process;GO:0090080|positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway;GO:0120162|positive regulation of cold-induced thermogenesis;GO:1901215|negative regulation of neuron death;GO:1904640|response to methionine;GO:2000352|negative regulation of endothelial cell apoptotic process;","GO:0005615|extracellular space;GO:0005737|cytoplasm;","GO:0003674|molecular_function;GO:0005104|fibroblast growth factor receptor binding;GO:0008083|growth factor activity;","K22429","FGF21; fibroblast growth factor 21"]
["ENSRNOG00000028377",1,0.084135269,11,0.70763482,0.118896451,-3.072222444,0.005876139,0.003911807,"down","yes","Mpl","protein_coding","chr5:131973895-131986797:-","gi|109477100|ref|XP_001072502.1|",3058,0,"PREDICTED: thrombopoietin receptor isoform X3 [Rattus norvegicus]","gi|672053926|ref|XM_345572.8|",3046,0,"PREDICTED: Rattus norvegicus MPL proto-oncogene, thrombopoietin receptor (Mpl), transcript variant X3, mRNA","Q08351",1068,0,"Thrombopoietin receptor",".",".",".",".","pfam09067","EpoR_lig-bind","Erythropoietin receptor, ligand binding. Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.","GO:0001780|neutrophil homeostasis;GO:0010628|positive regulation of gene expression;GO:0030220|platelet formation;GO:0032642|regulation of chemokine production;GO:0035702|monocyte homeostasis;GO:0038163|thrombopoietin-mediated signaling pathway;GO:0043066|negative regulation of apoptotic process;GO:0048872|homeostasis of number of cells;GO:0050671|positive regulation of lymphocyte proliferation;GO:0060216|definitive hemopoiesis;GO:0070527|platelet aggregation;GO:0071456|cellular response to hypoxia;GO:0072091|regulation of stem cell proliferation;GO:1905221|positive regulation of platelet formation;GO:1990959|eosinophil homeostasis;GO:1990960|basophil homeostasis;GO:2000035|regulation of stem cell division;","GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0031965|nuclear membrane;GO:0043005|neuron projection;GO:0043025|neuronal cell body;","GO:0003674|molecular_function;GO:0038164|thrombopoietin receptor activity;","K05082","TPOR, MPL, CD110; thrombopoietin receptor"]
["ENSRNOG00000067412",1,0.084135269,11,0.70763482,0.118896451,-3.072222444,0.005876139,0.003911807,"down","yes","ENSRNOG00000067412","lncRNA","chr3:22726862-22730706:+","gi|1587031|prf||2205312A",365,{"v":3e-33,"d":"3.00E-33"},"cis-Golgi matrix protein GM130","gi|672016722|ref|XR_344874.2|",1076,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102554600 (LOC102554600), transcript variant X2, ncRNA","Q62839",145,{"v":6E-34,"d":"6.00E-34"},"Golgin subfamily A member 2",".",".",".",".","pfam15070","GOLGA2L5","Putative golgin subfamily A member 2-like protein 5. The function of the GOLGA2L5 protein family remains unknown. This family of proteins is thought to be found in the Golgi apparatus of eukaryotes. Proteins in this family are typically between and 840 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000068574",1,0.084135269,11,0.70763482,0.118896451,-3.072222444,0.005876139,0.003911807,"down","yes","ENSRNOG00000068574","protein_coding","chr1:210224960-210225360:+","gi|821012392|ref|XP_012356602.1|",266,{"v":1e-34,"d":"1.00E-34"},"PREDICTED: T-complex protein 1 subunit eta isoform X2 [Nomascus leucogenys]","gi|602682317|ref|XM_007453368.1|",177,{"v":3e-86,"d":"3.00E-86"},"PREDICTED: Lipotes vexillifer chaperonin containing TCP1, subunit 7 (eta) (CCT7), transcript variant X3, mRNA","Q5R5C8",106,{"v":7e-27,"d":"7.00E-27"},"T-complex protein 1 subunit eta","SPBC25H2.12c",67.4,{"v":2e-13,"d":"2.00E-13"},"COG0459","pfam00118","Cpn60_TCP1","TCP-1/cpn60 chaperonin family. This family includes members from the HSP60 chaperone family and the TCP-1 (T-complex protein) family.",".",".",".",".","."]
["ENSRNOG00000014907",6,0.504811612,24,1.543930516,0.32696524,-1.612790825,0.005948472,0.003953194,"down","yes","Aldh8a1","protein_coding","chr1:16183940-16203385:+","gi|564324672|ref|XP_006227736.1|",2532,0,"PREDICTED: aldehyde dehydrogenase family 8 member A1 isoform X1 [Rattus norvegicus]","gi|672033831|ref|XM_006227674.2|",1660,0,"PREDICTED: Rattus norvegicus aldehyde dehydrogenase 8 family, member A1 (Aldh8a1), transcript variant X1, mRNA","Q8BH00",916,0,"Aldehyde dehydrogenase family 8 member A1","STM1102",382,{"v":4E-125,"d":"4.00E-125"},"COG1012","pfam00171","Aldedh","Aldehyde dehydrogenase family. This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:1.2.1.3. Succinate-semialdehyde dehydrogenase EC:1.2.1.16. Lactaldehyde dehydrogenase EC:1.2.1.22. Benzaldehyde dehydrogenase EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase EC: 1.5.1.12. Acetaldehyde dehydrogenase EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase EC:1.2.1.41. This family also includes omega crystallin, an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.","GO:0042573|retinoic acid metabolic process;GO:0042574|retinal metabolic process;GO:0042904|9-cis-retinoic acid biosynthetic process;",".","GO:0001758|retinal dehydrogenase activity;GO:0016620|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor;","K23234","ALDH8A1; aminomuconate-semialdehyde dehydrogenase [EC:1.2.1.32]"]
["ENSRNOG00000056087",6,0.504811612,24,1.543930516,0.32696524,-1.612790825,0.005948472,0.003953194,"down","yes","Erich2","protein_coding","chr3:55310993-55347184:+","gi|66730305|ref|NP_001019482.1|",1643,0,"glutamate-rich protein 2 [Rattus norvegicus]","gi|66730304|ref|NM_001024311.1|",1653,0,"Rattus norvegicus glutamate-rich 2 (Erich2), mRNA",".",".",".",".",".",".",".",".","pfam15402","Spc7_N","N-terminus of kinetochore NMS complex subunit Spc7.",".",".",".",".","."]
["ENSRNOG00000021130",2,0.168270537,14,0.900626135,0.18683728,-2.420145747,0.006127372,0.004060192,"down","yes","Abcc8","protein_coding","chr1:96598647-96679510:-","gi|148368981|ref|NP_037171.2|",7574,0,"ATP-binding cassette sub-family C member 8 [Rattus norvegicus]","gi|11691885|dbj|AB052294.1|",4777,0,"Rattus norvegicus SUR1 mRNA for sulphonylurea receptor 1, complete cds","Q09429",2922,0,"ATP-binding cassette sub-family C member 8","YDR135c",598,0,"COG1132","pfam00664","ABC_membrane","ABC transporter transmembrane region. This family represents a unit of six transmembrane helices. Many members of the ABC transporter family (pfam00005) have two such regions.","GO:0001678|cellular glucose homeostasis;GO:0007565|female pregnancy;GO:0007613|memory;GO:0008542|visual learning;GO:0009268|response to pH;GO:0009410|response to xenobiotic stimulus;GO:0010043|response to zinc ion;GO:0010989|negative regulation of low-density lipoprotein particle clearance;GO:0016525|negative regulation of angiogenesis;GO:0032496|response to lipopolysaccharide;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032868|response to insulin;GO:0043268|positive regulation of potassium ion transport;GO:0046676|negative regulation of insulin secretion;GO:0050768|negative regulation of neurogenesis;GO:0055085|transmembrane transport;GO:0060253|negative regulation of glial cell proliferation;GO:0061045|negative regulation of wound healing;GO:0061855|negative regulation of neuroblast migration;GO:0071310|cellular response to organic substance;GO:0071805|potassium ion transmembrane transport;GO:1900721|positive regulation of uterine smooth muscle relaxation;GO:1903818|positive regulation of voltage-gated potassium channel activity;GO:1905075|positive regulation of tight junction disassembly;GO:1905604|negative regulation of maintenance of permeability of blood-brain barrier;","GO:0005739|mitochondrion;GO:0005886|plasma membrane;GO:0008282|inward rectifying potassium channel;GO:0016020|membrane;GO:0030672|synaptic vesicle membrane;GO:0031004|potassium ion-transporting ATPase complex;GO:0042383|sarcolemma;","GO:0005267|potassium channel activity;GO:0005524|ATP binding;GO:0008281|sulfonylurea receptor activity;GO:0019829|cation-transporting ATPase activity;GO:0042626|ATPase activity, coupled to transmembrane movement of substances;GO:0044325|ion channel binding;","K05032","ABCC8, SUR1; ATP-binding cassette subfamily C (CFTR/MRP) member 8"]
["ENSRNOG00000062636",2,0.168270537,14,0.900626135,0.18683728,-2.420145747,0.006127372,0.004060192,"down","yes","ENSRNOG00000062636","lncRNA","chr17:10116037-10142940:-","gi|984130624|ref|XP_015357259.1|",145,{"v":6e-14,"d":"6.00E-14"},"PREDICTED: transcription elongation factor SPT4-A-like [Marmota marmota marmota]","gi|672029761|ref|XR_598030.1|",170,{"v":6e-82,"d":"6.00E-82"},"PREDICTED: Rattus norvegicus uncharacterized LOC102551420 (LOC102551420), transcript variant X2, ncRNA","Q9Z199",64.3,{"v":9e-15,"d":"9.00E-15"},"Transcription elongation factor SPT4-B",".",".",".",".","pfam06093","Spt4","Spt4/RpoE2 zinc finger. This family consists of several eukaryotic transcription elongation Spt4 proteins as well as archaebacterial RpoE2. Three transcription-elongation factors Spt4, Spt5, and Spt6 are conserved among eukaryotes and are essential for transcription via the modulation of chromatin structure. Spt4 and Spt5 are tightly associated in a complex, while the physical association of the Spt4-Spt5 complex with Spt6 is considerably weaker. It has been demonstrated that Spt4, Spt5, and Spt6 play roles in transcription elongation in both yeast and humans including a role in activation by Tat. It is known that Spt4, Spt5, and Spt6 are general transcription-elongation factors, controlling transcription both positively and negatively in important regulatory and developmental roles. RpoE2 is one of 13 subunits in the archaeal RNA polymerase. These proteins contain a C4-type zinc finger, and the structure has been solved in. The structure reveals that Spt4-Spt5 binding is governed by an acid-dipole interaction between Spt5 and Spt4, and the complex binds to and travels along the elongating RNA polymerase. The Spt4-Spt5 complex is likely to be an ancient, core component of the transcription elongation machinery.",".",".",".",".","."]
["ENSRNOG00000063114",2,0.168270537,14,0.900626135,0.18683728,-2.420145747,0.006127372,0.004060192,"down","yes","ENSRNOG00000063114","lncRNA","chr1:224187736-224189816:-",".",".",".",".","gi|46240889|gb|AC118249.11|",169,{"v":1e-81,"d":"1.00E-81"},"Mus musculus chromosome 19, clone RP23-397G23, complete sequence",".",".",".",".",".",".",".",".","pfam11045","YbjM","Putative inner membrane protein of Enterobacteriaceae. This family is conserved in the Enterobacteriaceae. It is a putative inner membrane protein, named YbjM, but the function is not known.",".",".",".",".","."]
["ENSRNOG00000068910",2,0.168270537,14,0.900626135,0.18683728,-2.420145747,0.006127372,0.004060192,"down","yes","Olr157","protein_coding","chr1:158885881-158893038:+","gi|47576421|ref|NP_001000169.1|",1729,0,"olfactory receptor Olr157 [Rattus norvegicus]","gi|49615119|gb|AC113720.6|",3277,0,"Rattus norvegicus 1 BAC CH230-117B1 (Children's Hospital Oakland Research Institute) complete sequence","Q8NH57",591,0,"Putative olfactory receptor 52P1",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.",".",".",".",".","."]
["ENSRNOG00000069787",2,0.168270537,14,0.900626135,0.18683728,-2.420145747,0.006127372,0.004060192,"down","yes","ENSRNOG00000069787","lncRNA","chr3:62277369-62278419:-","gi|742177570|ref|XP_010851909.1|",630,{"v":8e-128,"d":"8.00E-128"},"PREDICTED: ribosome biogenesis protein NSA2 homolog [Bison bison bison]","gi|68534731|gb|BC098657.1|",881,0,"Rattus norvegicus CDK105 protein, mRNA (cDNA clone MGC:112601 IMAGE:7378282), complete cds","Q3SX11",245,{"v":7e-129,"d":"7.00E-129"},"Ribosome biogenesis protein NSA2 homolog","SPCP1E11.08",197,{"v":1E-59,"d":"1.00E-59"},"COG2007","pfam01201","Ribosomal_S8e","Ribosomal protein S8e.",".",".",".",".","."]
["ENSRNOG00000002031",7,0.588946881,26,1.672591393,0.352116412,-1.505875621,0.006466822,0.004267952,"down","yes","Naa11","protein_coding","chr14:12183651-12193686:+","gi|67078532|ref|NP_001019913.1|",1324,{"v":1e-171,"d":"1.00E-171"},"N-alpha-acetyltransferase 11 [Rattus norvegicus]","gi|67078531|ref|NM_001024742.1|",3229,0,"Rattus norvegicus N(alpha)-acetyltransferase 11, NatA catalytic subunit (Naa11), mRNA","Q4V8K3",514,{"v":3e-173,"d":"3.00E-173"},"N-alpha-acetyltransferase 11","SPAC15E1.08",220,{"v":8e-65,"d":"8.00E-65"},"COG0456","pfam00583","Acetyltransf_1","Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.","GO:0006474|N-terminal protein amino acid acetylation;GO:0017198|N-terminal peptidyl-serine acetylation;GO:0018002|N-terminal peptidyl-glutamic acid acetylation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005794|Golgi apparatus;GO:0005813|centrosome;GO:0005829|cytosol;GO:0031415|NatA complex;","GO:0004596|peptide alpha-N-acetyltransferase activity;GO:1990189|peptide-serine-N-acetyltransferase activity;GO:1990190|peptide-glutamate-N-acetyltransferase activity;","K20791","NAA10_11, ARD1_2; N-alpha-acetyltransferase 10/11 [EC:2.3.1.255]"]
["ENSRNOG00000015148",7,0.588946881,26,1.672591393,0.352116412,-1.505875621,0.006466822,0.004267952,"down","yes","Erc2","protein_coding","chr16:2848620-3670776:+","gi|37360977|ref|NP_808482.2|",4265,0,"ERC protein 2 [Mus musculus]","gi|22138112|gb|AY049038.1|",2851,0,"Rattus norvegicus CAST1 mRNA, complete cds","Q8K3M6",1565,0,"ERC protein 2",".",".",".",".","pfam10174","Cast","RIM-binding protein of the cytomatrix active zone. This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.","GO:0007274|neuromuscular synaptic transmission;GO:0007416|synapse assembly;GO:0016082|synaptic vesicle priming;GO:0048167|regulation of synaptic plasticity;GO:0048790|maintenance of presynaptic active zone structure;GO:0050808|synapse organization;","GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005798|Golgi-associated vesicle;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0030426|growth cone;GO:0032991|protein-containing complex;GO:0042734|presynaptic membrane;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0045202|synapse;GO:0048786|presynaptic active zone;GO:0048788|cytoskeleton of presynaptic active zone;GO:0098831|presynaptic active zone cytoplasmic component;GO:0098978|glutamatergic synapse;GO:0098982|GABA-ergic synapse;","GO:0005515|protein binding;GO:0030165|PDZ domain binding;GO:0044877|protein-containing complex binding;GO:0098882|structural constituent of presynaptic active zone;","K19878","ERC2, CAST; ELKS/RAB6-interacting/CAST family member 2"]
["ENSRNOG00000000282",0,0.042067634,9,0.578973944,0.072658942,-3.782715827,6.678153E-3,0.00439361,"down","yes","Gsc2","protein_coding","chr11:83072138-83074126:+","gi|157817310|ref|NP_001102316.1|",721,{"v":1e-90,"d":"1.00E-90"},"homeobox protein goosecoid-2 [Rattus norvegicus]","gi|157817309|ref|NM_001108846.1|",1127,0,"Rattus norvegicus goosecoid homeobox 2 (Gsc2), mRNA","P56916",227,{"v":6e-71,"d":"6.00E-71"},"Homeobox protein goosecoid-2",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0006357|regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09325","GSCL; homeobox protein goosecoid-like"]
["ENSRNOG00000005250",0,0.042067634,9,0.578973944,0.072658942,-3.782715827,6.678153E-3,0.00439361,"down","yes","Abcg5","protein_coding","chr6:9965118-9990563:+","gi|26024223|ref|NP_446206.2|",3403,0,"ATP-binding cassette sub-family G member 5 [Rattus norvegicus]","gi|26024222|ref|NM_053754.2|",2458,0,"Rattus norvegicus ATP binding cassette subfamily G member 5 (Abcg5), mRNA","Q99PE7",1315,0,"ATP-binding cassette sub-family G member 5",".",".",".",".","pfam00005","ABC_tran","ABC transporter. ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide or belong in different polypeptide chains.","GO:0007584|response to nutrient;GO:0007588|excretion;GO:0009410|response to xenobiotic stimulus;GO:0010212|response to ionizing radiation;GO:0010949|negative regulation of intestinal phytosterol absorption;GO:0014850|response to muscle activity;GO:0015918|sterol transport;GO:0031667|response to nutrient levels;GO:0033344|cholesterol efflux;GO:0038183|bile acid signaling pathway;GO:0042632|cholesterol homeostasis;GO:0045796|negative regulation of intestinal cholesterol absorption;GO:0055085|transmembrane transport;GO:0070328|triglyceride homeostasis;GO:0120009|intermembrane lipid transfer;","GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0016324|apical plasma membrane;GO:0043190|ATP-binding cassette (ABC) transporter complex;GO:0043235|receptor complex;GO:0045177|apical part of cell;","GO:0005524|ATP binding;GO:0016887|ATPase activity;GO:0042626|ATPase activity, coupled to transmembrane movement of substances;GO:0046872|metal ion binding;GO:0046982|protein heterodimerization activity;GO:0120020|intermembrane cholesterol transfer activity;","K05683","ABCG5; ATP-binding cassette, subfamily G (WHITE), member 5 (sterolin 1)"]
["ENSRNOG00000012595",0,0.042067634,9,0.578973944,0.072658942,-3.782715827,6.678153E-3,0.00439361,"down","yes","AC124205.1","protein_coding","chr5:135069026-135070082:+","gi|568991766|ref|XP_006520701.1|",1526,0,"PREDICTED: twinfilin-1 isoform X1 [Mus musculus]","gi|56606099|ref|NM_001008521.1|",721,0,"Rattus norvegicus twinfilin actin-binding protein 1 (Twf1), mRNA","Q5RJR2",592,0,"Twinfilin-1",".",".",".",".","pfam00241","Cofilin_ADF","Cofilin/tropomyosin-type actin-binding protein. Severs actin filaments and binds to actin monomers.",".",".",".",".","."]
["ENSRNOG00000012608",0,0.042067634,9,0.578973944,0.072658942,-3.782715827,6.678153E-3,0.00439361,"down","yes","Tmem212","protein_coding","chr2:110775953-110813273:-","gi|672042017|ref|XP_008759120.1|",1036,{"v":1E-135,"d":"1.00E-135"},"PREDICTED: transmembrane protein 212 isoform X2 [Rattus norvegicus]","gi|256574777|ref|NM_001164438.1|",746,0,"Rattus norvegicus transmembrane protein 212 (Tmem212), transcript variant 1, mRNA","Q8C6V3",346,{"v":4e-115,"d":"4.00E-115"},"Transmembrane protein 212",".",".",".",".","pfam05805","L6_membrane","L6 membrane protein. This family consists of several eukaryotic L6 membrane proteins. L6, IL-TMP, and TM4SF5 are cell surface proteins predicted to have four transmembrane domains. Previous sequence analysis led to their assignment as members of the tetraspanin superfamily it has now been found that that they are not significantly related to genuine tetraspanins, but instead constitute their own L6 family. Several members of this family have been implicated in human cancer.",".","GO:0016021|integral component of membrane;",".","K22196","TMEM212; transmembrane protein 212"]
["ENSRNOG00000017438",0,0.042067634,9,0.578973944,0.072658942,-3.782715827,6.678153E-3,0.00439361,"down","yes","AABR07007068.1","protein_coding","chr1:257321742-257551473:-","gi|6978888|ref|NP_037091.1|",2291,0,"GDNF family receptor alpha-1 precursor [Rattus norvegicus]","gi|1399862|gb|U59486.1|RNU59486",2134,0,"Rattus norvegicus GDNF receptor alpha mRNA, complete cds","Q62997",882,0,"GDNF family receptor alpha-1",".",".",".",".","pfam02351","GDNF","GDNF/GAS1 domain. This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.",".",".",".",".","."]
["ENSRNOG00000022548",0,0.042067634,9,0.578973944,0.072658942,-3.782715827,6.678153E-3,0.00439361,"down","yes","Prss38","protein_coding","chr10:44159346-44162488:-","gi|748982954|ref|NP_001291304.1|",1558,0,"protease, serine, 38 precursor [Rattus norvegicus]","gi|748982953|ref|NM_001304375.1|",1498,0,"Rattus norvegicus protease, serine, 38 (Prss38), mRNA","Q3UKY7",481,{"v":8E-167,"d":"8.00E-167"},"Serine protease 38","VC1649",94,{"v":1e-19,"d":"1.00E-19"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;",".","GO:0004252|serine-type endopeptidase activity;",".","."]
["ENSRNOG00000030840",0,0.042067634,9,0.578973944,0.072658942,-3.782715827,6.678153E-3,0.00439361,"down","yes","Cadm2","protein_coding","chr11:4555159-5525400:-","gi|568997528|ref|XP_006523091.1|",2045,0,"PREDICTED: cell adhesion molecule 2 isoform X3 [Mus musculus]","gi|755554972|ref|XM_006523028.2|",2329,0,"PREDICTED: Mus musculus cell adhesion molecule 2 (Cadm2), transcript variant X3, mRNA","Q8BLQ9",792,0,"Cell adhesion molecule 2",".",".",".",".","pfam08205","C2-set_2","CD80-like C2-set immunoglobulin domain. These domains belong to the immunoglobulin superfamily.","GO:0007155|cell adhesion;GO:0007420|brain development;","GO:0005737|cytoplasm;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0032809|neuronal cell body membrane;GO:0045202|synapse;","GO:0005515|protein binding;","K06782","CADM2, IGSF4D, NECL3; cell adhesion molecule 2"]
["ENSRNOG00000033910",0,0.042067634,9,0.578973944,0.072658942,-3.782715827,6.678153E-3,0.00439361,"down","yes","Tmprss11c","protein_coding","chr14:21782124-21837793:+","gi|51571899|ref|NP_001003979.1|",2126,0,"transmembrane protease, serine 11C [Rattus norvegicus]","gi|187955199|gb|BC147157.1|",1026,0,"Mus musculus transmembrane protease, serine 11c, mRNA (cDNA clone MGC:182311 IMAGE:9056205), complete cds","Q1JRP2",808,0,"Transmembrane protease serine 11C","mlr3307",113,{"v":2e-27,"d":"2.00E-27"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;GO:0097264|self proteolysis;","GO:0005576|extracellular region;GO:0005887|integral component of plasma membrane;GO:0030425|dendrite;GO:0043204|perikaryon;","GO:0004252|serine-type endopeptidase activity;","K14359","TMPRSS11C; transmembrane protease serine 11C [EC:3.4.21.-]"]
["ENSRNOG00000035553",0,0.042067634,9,0.578973944,0.072658942,-3.782715827,6.678153E-3,0.00439361,"down","yes","Mir202","miRNA","chr1:194754730-194754801:-",".",".",".",".","gi|297139716|ref|NR_032736.1|",72,{"v":1e-28,"d":"1.00E-28"},"Rattus norvegicus microRNA 202 (Mir202), microRNA",".",".",".",".",".",".",".",".","pfam05717","TnpB_IS66","IS66 Orf2 like protein. This protein is found in insertion sequences related to IS66. The function of these proteins is uncertain, but they are probably essential for transposition.","GO:0046661|male sex differentiation;GO:0071222|cellular response to lipopolysaccharide;",".",".","K17149","MIR202; microRNA 202"]
["ENSRNOG00000035616",0,0.042067634,9,0.578973944,0.072658942,-3.782715827,6.678153E-3,0.00439361,"down","yes","Mir3574","miRNA","chr1:196326337-196326454:+","gi|586493244|ref|XP_006877069.1|",127,3e-07,"PREDICTED: atrophin-1-like [Chrysochloris asiatica]","gi|312147346|ref|NR_037366.1|",118,{"v":6e-54,"d":"6.00E-54"},"Rattus norvegicus microRNA 3574 (Mir3574), microRNA",".",".",".",".",".",".",".",".","pfam03122","Herpes_MCP","Herpes virus major capsid protein. This family represents the major capsid protein (MCP) of herpes viruses. The capsid shell consists of 150 MCP hexamers and 12 MCP pentamers. One pentamer is found at each of the 12 apices of the icosahedral shell, and the hexamers form the edges and 20 faces.","GO:0030509|BMP signaling pathway;GO:0032926|negative regulation of activin receptor signaling pathway;GO:0045669|positive regulation of osteoblast differentiation;GO:0071222|cellular response to lipopolysaccharide;GO:1990830|cellular response to leukemia inhibitory factor;",".",".","K17178","MIR210; microRNA 210"]
["ENSRNOG00000056183",0,0.042067634,9,0.578973944,0.072658942,-3.782715827,6.678153E-3,0.00439361,"down","yes","AABR07030781.1","snoRNA","chr10:100770794-100770925:-",".",".",".",".","gi|298897740|emb|FQ227960.1|",98,{"v":1E-42,"d":"1.00E-42"},"Rattus norvegicus TL0AEA11YB07 mRNA sequence",".",".",".",".",".",".",".",".","pfam08995","NIP_1","Necrosis inducing protein-1. Necrosis inducing protein-1, a fungal avirulence protein produced by plants, consists of two parts containing beta-sheets of two and three anti-parallel strands, respectively. Five intramolecular disulfide bonds, stabilize these parts and their position with respect to each other, providing a high level of stability.",".",".",".",".","."]
["ENSRNOG00000058584",0,0.042067634,9,0.578973944,0.072658942,-3.782715827,6.678153E-3,0.00439361,"down","yes","U6","snRNA","chr15:24139858-24139961:+",".",".",".",".","gi|5360707|dbj|AB023065.1|",104,{"v":3e-46,"d":"3.00E-46"},"Rattus norvegicus Prsmg1/Gcpl1 and Apex genes for O-sialoglycoprotease and Apex nuclease, partial and complete cds",".",".",".",".",".",".",".",".","pfam15316","MDFI","MyoD family inhibitor. Members of this family inhibits the transactivation activity of the MyoD family of myogenic factors. They affect axin-mediated regulation of the Wnt and JNK signaling pathways, and regulate expression from viral promoters.",".",".",".",".","."]
["ENSRNOG00000062961",0,0.042067634,9,0.578973944,0.072658942,-3.782715827,6.678153E-3,0.00439361,"down","yes","ENSRNOG00000062961","lncRNA","chr1:35318705-35326361:-","gi|672064193|ref|XP_008765045.1|",304,{"v":1e-29,"d":"1.00E-29"},"PREDICTED: uncharacterized protein LOC685976 isoform X4 [Rattus norvegicus]","gi|672042620|ref|XR_591124.1|",476,0,"PREDICTED: Rattus norvegicus similar to nidogen 2 (LOC365085), transcript variant X16, misc_RNA","Q8R1R5",89.7,{"v":9e-19,"d":"9.00E-19"},"CD99 antigen-like protein 2",".",".",".",".","pfam06022","Cir_Bir_Yir","Plasmodium variant antigen protein Cir/Yir/Bir. This family consists of several Cir, Yir and Bir proteins from the Plasmodium species P.chabaudi, P.yoelii and P.berghei.",".",".",".",".","."]
["ENSRNOG00000064188",0,0.042067634,9,0.578973944,0.072658942,-3.782715827,6.678153E-3,0.00439361,"down","yes","ENSRNOG00000064188","lncRNA","chr13:71428204-71429653:+","gi|820998709|ref|XP_012368625.1|",150,1e-07,"PREDICTED: uncharacterized protein LOC105741223 [Octodon degus]","gi|354788884|gb|JN953385.1|",357,0,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Rfwd2:tm1e(EUCOMM)Hmgu; transgenic",".",".",".",".",".",".",".",".","pfam00429","TLV_coat","ENV polyprotein (coat polyprotein).",".",".",".",".","."]
["ENSRNOG00000064636",0,0.042067634,9,0.578973944,0.072658942,-3.782715827,6.678153E-3,0.00439361,"down","yes","ENSRNOG00000064636","lncRNA","chr7:365492-369191:-","gi|149050529|gb|EDM02702.1|",329,{"v":2e-29,"d":"2.00E-29"},"zinc finger protein 36, C3H type-like 2 [Rattus norvegicus]","gi|672057587|ref|XM_008765049.1|",1298,0,"PREDICTED: Rattus norvegicus zinc finger protein 36, C3H1 type-like 2-like (LOC100911319), transcript variant X1, mRNA","P23949",127,{"v":2e-29,"d":"2.00E-29"},"mRNA decay activator protein ZFP36L2",".",".",".",".","pfam00642","zf-CCCH","Zinc finger C-x8-C-x5-C-x3-H type (and similar).",".",".",".",".","."]
["ENSRNOG00000066322",0,0.042067634,9,0.578973944,0.072658942,-3.782715827,6.678153E-3,0.00439361,"down","yes","Olr159","protein_coding","chr1:158916975-158920576:+","gi|47576465|ref|NP_001000170.1|",1578,0,"olfactory receptor Olr159 [Rattus norvegicus]","gi|49615119|gb|AC113720.6|",1614,0,"Rattus norvegicus 1 BAC CH230-117B1 (Children's Hospital Oakland Research Institute) complete sequence","Q8NGI2",547,0,"Olfactory receptor 52N4",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.",".",".",".",".","."]
["ENSRNOG00000066556",0,0.042067634,9,0.578973944,0.072658942,-3.782715827,6.678153E-3,0.00439361,"down","yes","Fgf23","protein_coding","chr4:159914272-159923821:+","gi|18543369|ref|NP_570110.1|",1202,{"v":8e-156,"d":"8.00E-156"},"fibroblast growth factor 23 precursor [Rattus norvegicus]","gi|471434825|ref|NM_022657.4|",944,0,"Mus musculus fibroblast growth factor 23 (Fgf23), mRNA","Q8VI82",467,{"v":3E-157,"d":"3.00E-157"},"Fibroblast growth factor 23",".",".",".",".","pfam00167","FGF","Fibroblast growth factor. Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide range of contexts. They are found in a wide range of organisms, from nematodes to humans. Most share an internal core region of high similarity, conserved residues in which are involved in binding with their receptors. On binding, they cause dimerization of their tyrosine kinase receptors leading to intracellular signalling. There are currently four known tyrosine kinase receptors for fibroblast growth factors. These receptors can each bind several different members of this family. Members of this family have a beta trefoil structure. Most have N-terminal signal peptides and are secreted. A few lack signal sequences but are secreted anyway; still others also lack the signal peptide but are found on the cell surface and within the extracellular matrix. A third group remain intracellular. They have central roles in development, regulating cell proliferation, migration and differentiation. On the other hand, they are important in tissue repair following injury in adult organisms.",".",".",".",".","."]
["ENSRNOG00000066817",0,0.042067634,9,0.578973944,0.072658942,-3.782715827,6.678153E-3,0.00439361,"down","yes","ENSRNOG00000066817","lncRNA","chr4:153521057-153533698:-",".",".",".",".","gi|31581812|gb|AC135963.3|",90,{"v":1e-37,"d":"1.00E-37"},"Mus musculus BAC clone RP23-346N11 from chromosome 7, complete sequence",".",".",".",".",".",".",".",".","pfam15324","TALPID3","Hedgehog signalling target. TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.",".",".",".",".","."]
["ENSRNOG00000068596",0,0.042067634,9,0.578973944,0.072658942,-3.782715827,6.678153E-3,0.00439361,"down","yes","ENSRNOG00000068596","lncRNA","chr17:10110742-10113602:-","gi|350537301|ref|NP_001233663.1|",163,{"v":8e-11,"d":"8.00E-11"},"uncharacterized protein LOC100689233 [Cricetulus griseus]","gi|672081208|ref|XR_596625.1|",489,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102551420 (LOC102551420), transcript variant X4, ncRNA",".",".",".",".",".",".",".",".","pfam02365","NAM","No apical meristem (NAM) protein. This is a family of no apical meristem (NAM) proteins these are plant development proteins. Mutations in NAM result in the failure to develop a shoot apical meristem in petunia embryos. NAM is indicated as having a role in determining positions of meristems and primordial. One member of this family NAP (NAC-like, activated by AP3/PI) is encoded by the target genes of the AP3/PI transcriptional activators and functions in the transition between growth by cell division and cell expansion in stamens and petals.",".",".",".",".","."]
["ENSRNOG00000066747",15,1.26202903,42,2.701878404,0.4670932,-1.098217652,0.006751826,0.004435113,"down","yes","ENSRNOG00000066747","lncRNA","chr14:94560541-94568345:+","gi|149044753|gb|EDL97939.1|",322,{"v":2e-31,"d":"2.00E-31"},"rCG23265, partial [Rattus norvegicus]","gi|672028179|ref|XR_340440.2|",745,0,"PREDICTED: Rattus norvegicus uncharacterized LOC100911950 (LOC100911950), ncRNA",".",".",".",".",".",".",".",".","pfam05784","Herpes_UL82_83","Betaherpesvirus UL82/83 protein N terminus. This family represents the N terminal region of the Betaherpesvirus UL82 and UL83 proteins. As viruses are reliant upon their host cell to serve as proper environments for their replication, many have evolved mechanisms to alter intracellular conditions to suit their own needs. Human cytomegalovirus induces quiescent cells to enter the cell cycle and then arrests them in late G(1), before they enter the S phase, a cell cycle compartment that is presumably favourable for viral replication. The protein product of the human cytomegalovirus UL82 gene, pp71, can accelerate the movement of cells through the G(1) phase of the cell cycle. This activity would help infected cells reach the late G(1) arrest point sooner and thus may stimulate the infectious cycle. pp71 also induces DNA synthesis in quiescent cells, but a pp71 mutant protein that is unable to induce quiescent cells to enter the cell cycle still retains the ability to accelerate the G(1) phase. Thus, the mechanism through which pp71 accelerates G(1) cell cycle progression appears to be distinct from the one that it employs to induce quiescent cells to exit G(0) and subsequently enter the S phase.",".",".",".",".","."]
["ENSRNOG00000017050",8,0.673082149,28,1.801252269,0.37367456,-1.420145747,6.832004E-3,0.004481676,"down","yes","Lmntd2","protein_coding","chr1:196315115-196319156:-","gi|189011643|ref|NP_001121012.1|",3320,0,"uncharacterized protein C11orf35 homolog [Rattus norvegicus]","gi|672038877|ref|XM_008759991.1|",2077,0,"PREDICTED: Rattus norvegicus lamin tail domain containing 2 (Lmntd2), transcript variant X3, mRNA","Q0VET5",1082,0,"Lamin tail domain-containing protein 2",".",".",".",".","pfam00932","LTD","Lamin Tail Domain. The lamin-tail domain (LTD), which has an immunoglobulin (Ig) fold, is found in Nuclear Lamins, Chlo1887 from Chloroflexus, and several bacterial proteins where it occurs with membrane associated hydrolases of the metallo-beta-lactamase,synaptojanin, and calcineurin-like phosphoesterase superfamilies.","GO:0010847|regulation of chromatin assembly;GO:0048026|positive regulation of mRNA splicing, via spliceosome;","GO:0005638|lamin filament;","GO:0030527|structural constituent of chromatin;",".","."]
["ENSRNOG00000004473",4,0.336541075,19,1.222278326,0.275339149,-1.860718339,0.006833411,0.004481676,"down","yes","Ppargc1a","protein_coding","chr14:58861144-59512656:+","gi|672076432|ref|XP_008768441.1|",2672,0,"PREDICTED: peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [Rattus norvegicus]","gi|880877600|ref|XM_005068780.2|",2538,0,"PREDICTED: Mesocricetus auratus peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (Ppargc1a), transcript variant X2, mRNA","Q9QYK2",1031,0,"Peroxisome proliferator-activated receptor gamma coactivator 1-alpha",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0000302|response to reactive oxygen species;GO:0000422|autophagy of mitochondrion;GO:0001666|response to hypoxia;GO:0001933|negative regulation of protein phosphorylation;GO:0002021|response to dietary excess;GO:0002931|response to ischemia;GO:0006012|galactose metabolic process;GO:0006094|gluconeogenesis;GO:0006355|regulation of transcription, DNA-templated;GO:0007005|mitochondrion organization;GO:0007568|aging;GO:0008209|androgen metabolic process;GO:0009409|response to cold;GO:0009410|response to xenobiotic stimulus;GO:0009750|response to fructose;GO:0010628|positive regulation of gene expression;GO:0010822|positive regulation of mitochondrion organization;GO:0014070|response to organic cyclic compound;GO:0014732|skeletal muscle atrophy;GO:0014823|response to activity;GO:0014850|response to muscle activity;GO:0014878|response to electrical stimulus involved in regulation of muscle adaptation;GO:0014912|negative regulation of smooth muscle cell migration;GO:0019395|fatty acid oxidation;GO:0021549|cerebellum development;GO:0022904|respiratory electron transport chain;GO:0030900|forebrain development;GO:0031325|positive regulation of cellular metabolic process;GO:0031667|response to nutrient levels;GO:0032922|circadian regulation of gene expression;GO:0034599|cellular response to oxidative stress;GO:0035865|cellular response to potassium ion;GO:0042594|response to starvation;GO:0042752|regulation of circadian rhythm;GO:0043201|response to leucine;GO:0043524|negative regulation of neuron apoptotic process;GO:0045820|negative regulation of glycolytic process;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046321|positive regulation of fatty acid oxidation;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0048662|negative regulation of smooth muscle cell proliferation;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051552|flavone metabolic process;GO:0051602|response to electrical stimulus;GO:0060612|adipose tissue development;GO:0071222|cellular response to lipopolysaccharide;GO:0071250|cellular response to nitrite;GO:0071313|cellular response to caffeine;GO:0071332|cellular response to fructose stimulus;GO:0071333|cellular response to glucose stimulus;GO:0071354|cellular response to interleukin-6;GO:0071356|cellular response to tumor necrosis factor;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0071392|cellular response to estradiol stimulus;GO:0071398|cellular response to fatty acid;GO:0071456|cellular response to hypoxia;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0071871|response to epinephrine;GO:0071873|response to norepinephrine;GO:0090258|negative regulation of mitochondrial fission;GO:0097009|energy homeostasis;GO:0097066|response to thyroid hormone;GO:0097067|cellular response to thyroid hormone stimulus;GO:0120162|positive regulation of cold-induced thermogenesis;GO:1901215|negative regulation of neuron death;GO:1901558|response to metformin;GO:1901857|positive regulation of cellular respiration;GO:1901860|positive regulation of mitochondrial DNA metabolic process;GO:1901863|positive regulation of muscle tissue development;GO:1904635|positive regulation of glomerular visceral epithelial cell apoptotic process;GO:1904637|cellular response to ionomycin;GO:1904639|cellular response to resveratrol;GO:1904640|response to methionine;GO:1990845|adaptive thermogenesis;GO:2000184|positive regulation of progesterone biosynthetic process;GO:2000272|negative regulation of signaling receptor activity;GO:2000310|regulation of NMDA receptor activity;GO:2001171|positive regulation of ATP biosynthetic process;","GO:0000791|euchromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;GO:0016605|PML body;GO:0022626|cytosolic ribosome;GO:0043025|neuronal cell body;GO:0043231|intracellular membrane-bounded organelle;GO:0097440|apical dendrite;","GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003713|transcription coactivator activity;GO:0003723|RNA binding;GO:0005515|protein binding;GO:0008134|transcription factor binding;GO:0016922|nuclear receptor binding;GO:0030331|estrogen receptor binding;GO:0030374|nuclear receptor transcription coactivator activity;GO:0031490|chromatin DNA binding;GO:0031625|ubiquitin protein ligase binding;GO:0042975|peroxisome proliferator activated receptor binding;GO:0043014|alpha-tubulin binding;GO:0043565|sequence-specific DNA binding;GO:1990841|promoter-specific chromatin binding;","K07202","PPARGC1A, PGC1A; alpha peroxisome proliferator-activated receptor gamma coactivator 1-alpha"]
["ENSRNOG00000023920",4,0.336541075,19,1.222278326,0.275339149,-1.860718339,0.006833411,0.004481676,"down","yes","Zfp791","protein_coding","chr19:23018918-23033504:+","gi|672031152|ref|XP_008772431.1|",2948,0,"PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 791-like isoform X1 [Rattus norvegicus]","gi|672084603|ref|XM_008772433.1|",1746,0,"PREDICTED: Rattus norvegicus rCG51614-like (LOC100363196), transcript variant X3, mRNA","Q5REI6",758,0,"Zinc finger protein 791",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000025494",4,0.336541075,19,1.222278326,0.275339149,-1.860718339,0.006833411,0.004481676,"down","yes","Nsun7","protein_coding","chr14:41879293-41934949:-","gi|564383618|ref|XP_006251008.1|",3627,0,"PREDICTED: putative methyltransferase NSUN7 isoform X1 [Rattus norvegicus]","gi|672076151|ref|XM_006250946.2|",3508,0,"PREDICTED: Rattus norvegicus NOP2/Sun domain family, member 7 (Nsun7), transcript variant X1, mRNA","Q14AW5",1120,0,"Putative methyltransferase NSUN7","SPAC2C4.06c",72.8,{"v":2E-12,"d":"2.00E-12"},"COG0144","pfam03379","CcmB","CcmB protein. CcmB is the product of one of a cluster of Ccm genes that are necessary for cytochrome c biosynthesis in eubacteria. Expression of these proteins is induced when the organisms are grown under anaerobic conditions with nitrate or nitrite as the final electron acceptor. CcmB is required for the export of haem to the periplasm.","GO:0030317|flagellated sperm motility;GO:0030382|sperm mitochondrion organization;GO:0032259|methylation;",".","GO:0003723|RNA binding;GO:0008168|methyltransferase activity;",".","."]
["ENSRNOG00000031947",14,1.177893761,40,2.573217527,0.457751336,-1.127363998,0.006932953,0.004542036,"down","yes","AABR07071986.1","protein_coding","chr1:180985438-180986209:+","gi|148706231|gb|EDL38178.1|",427,{"v":4E-50,"d":"4.00E-50"},"mCG5564, partial [Mus musculus]","gi|34849735|gb|BC058475.1|",370,0,"Rattus norvegicus ribosomal protein L36, mRNA (cDNA clone MGC:72835 IMAGE:6888196), complete cds","Q5RAZ9",166,{"v":8e-51,"d":"8.00E-51"},"60S ribosomal protein L36","SPCC970.05",87.4,{"v":4e-21,"d":"4.00E-21"},"COG5051","pfam01158","Ribosomal_L36e","Ribosomal protein L36e.",".",".",".",".","."]
["ENSRNOG00000061695",9,0.757217418,30,1.929913146,0.392358288,-1.349756419,0.007065418,0.004618815,"down","yes","Slc23a1","protein_coding","chr18:27216281-27230697:-","gi|564393109|ref|XP_006254664.1|",3376,0,"PREDICTED: solute carrier family 23 member 1 isoform X1 [Rattus norvegicus]","gi|672083077|ref|XM_006254602.2|",2659,0,"PREDICTED: Rattus norvegicus solute carrier family 23 (ascorbic acid transporter), member 1 (Slc23a1), transcript variant X1, mRNA","Q9WTW7",1150,0,"Solute carrier family 23 member 1","PAB1838",159,{"v":6e-41,"d":"6.00E-41"},"COG2233","pfam00860","Xan_ur_permease","Permease family. This family includes permeases for diverse substrates such as xanthine, uracil, and vitamin C. However many members of this family are functionally uncharacterized and may transport other substrates. Members of this family have ten predicted transmembrane helices.","GO:0006814|sodium ion transport;GO:0007420|brain development;GO:0009636|response to toxic substance;GO:0015882|L-ascorbic acid transmembrane transport;GO:0030324|lung development;GO:0035725|sodium ion transmembrane transport;GO:0070837|dehydroascorbic acid transport;GO:0070904|transepithelial L-ascorbic acid transport;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005903|brush border;GO:0009925|basal plasma membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0043229|intracellular organelle;","GO:0005215|transporter activity;GO:0008520|L-ascorbate:sodium symporter activity;GO:0015081|sodium ion transmembrane transporter activity;GO:0015229|L-ascorbic acid transmembrane transporter activity;GO:0033300|dehydroascorbic acid transmembrane transporter activity;","K14611","SLC23A1, SVCT1; solute carrier family 23 (nucleobase transporter), member 1"]
["ENSRNOG00000069157",12,1.009623224,36,2.315895775,0.435953653,-1.197753326,0.007178913,0.004689631,"down","yes","ENSRNOG00000069157","protein_coding","chr1:227987570-227988844:+","gi|61740629|ref|NP_001013449.1|",657,{"v":2e-81,"d":"2.00E-81"},"mitochondrial intermembrane space import and assembly protein 40 [Rattus norvegicus]","gi|61740628|ref|NM_001013431.1|",1235,0,"Rattus norvegicus coiled-coil-helix-coiled-coil-helix domain containing 4 (Chchd4), mRNA","Q5BJN5",257,{"v":5e-83,"d":"5.00E-83"},"Mitochondrial intermembrane space import and assembly protein 40",".",".",".",".","pfam06747","CHCH","CHCH domain. we have identified a conserved motif in the LOC118487 protein that we have called the CHCH motif. Alignment of this protein with related members showed the presence of three subgroups of proteins, which are called the S (Small), N (N-terminal extended) and C (C-terminal extended) subgroups. All three sub-groups of proteins have in common that they contain a predicted conserved [coiled coil 1]-[helix 1]-[coiled coil 2]-[helix 2] domain (CHCH domain). Within each helix of the CHCH domain, there are two cysteines present in a C-X9-C motif. The N-group contains an additional double helix domain, and each helix contains the C-X9-C motif. This family contains a number of characterized proteins: Cox19 protein - a nuclear gene of Saccharomyces cerevisiae, codes for an 11-kDa protein (Cox19p) required for expression of cytochrome oxidase. Because cox19 mutants are able to synthesize the mitochondrial and nuclear gene products of cytochrome oxidase, Cox19p probably functions post-translationally during assembly of the enzyme. Cox19p is present in the cytoplasm and mitochondria, where it exists as a soluble intermembrane protein. This dual location is similar to what was previously reported for Cox17p, a low molecular weight copper protein thought to be required for maturation of the CuA centre of subunit 2 of cytochrome oxidase. Cox19p have four conserved potential metal ligands, these are three cysteines and one histidine. Mrp10 - belongs to the class of yeast mitochondrial ribosomal proteins that are essential for translation. Eukaryotic NADH-ubiquinone oxidoreductase 19 kDa (NDUFA8) subunit. The CHCH domain was previously called DUF657.",".",".",".",".","."]
["ENSRNOG00000002004",10,0.841352686,32,2.058574022,0.40870655,-1.29086273,0.007188344,0.004694102,"down","yes","Prdm8","protein_coding","chr14:11404407-11410993:-","gi|672027688|ref|XP_008762818.1|",2506,0,"PREDICTED: PR domain zinc finger protein 8 isoform X2 [Rattus norvegicus]","gi|672075930|ref|XM_008770082.1|",3075,0,"PREDICTED: Rattus norvegicus PR domain containing 8 (Prdm8), transcript variant X4, mRNA","Q9NQV8",867,0,"PR domain zinc finger protein 8",".",".",".",".","pfam00096","zf-C2H2","Zinc finger, C2H2 type. The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.","GO:0006355|regulation of transcription, DNA-templated;GO:0008150|biological_process;GO:0014003|oligodendrocyte development;GO:0016571|histone methylation;GO:0021540|corpus callosum morphogenesis;GO:0021952|central nervous system projection neuron axonogenesis;GO:0021957|corticospinal tract morphogenesis;GO:0022008|neurogenesis;GO:0045892|negative regulation of transcription, DNA-templated;GO:0051567|histone H3-K9 methylation;","GO:0005575|cellular_component;GO:0005634|nucleus;","GO:0003674|molecular_function;GO:0003682|chromatin binding;GO:0003714|transcription corepressor activity;GO:0042054|histone methyltransferase activity;GO:0046974|histone methyltransferase activity (H3-K9 specific);","K20797","PRDM8; PR domain zinc finger protein 8 [EC:2.1.1.-]"]
["ENSRNOG00000017130",10,0.841352686,32,2.058574022,0.40870655,-1.29086273,0.007188344,0.004694102,"down","yes","Rhd","protein_coding","chr5:147087518-147121715:+","gi|11968076|ref|NP_071950.1|",2164,0,"blood group Rh(D) polypeptide [Rattus norvegicus]","gi|40254767|ref|NM_022505.2|",1482,0,"Rattus norvegicus Rh blood group, D antigen (Rhd), mRNA","O88298",838,0,"Blood group Rh(D) polypeptide",".",".",".",".","pfam00909","Ammonium_transp","Ammonium Transporter Family.","GO:0015696|ammonium transport;GO:0048821|erythrocyte development;GO:0060586|multicellular organismal iron ion homeostasis;GO:0072488|ammonium transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0016020|membrane;","GO:0008519|ammonium transmembrane transporter activity;","K06579","RH, CD240; Rhesus blood group glycoprotein"]
["ENSRNOG00000063097",10,0.841352686,32,2.058574022,0.40870655,-1.29086273,0.007188344,0.004694102,"down","yes","ENSRNOG00000063097","lncRNA","chr2:183414511-183415673:-",".",".",".",".","gi|298903760|emb|FQ213772.1|",1154,0,"Rattus norvegicus TL0AAA45YM10 mRNA sequence",".",".",".",".",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.",".",".",".",".","."]
["ENSRNOG00000011688",11,0.925487955,34,2.187234898,0.423131487,-1.240822048,0.007220393,0.004712364,"down","yes","Neil3","protein_coding","chr16:38359371-38418527:+","gi|281332206|ref|NP_001163817.1|",3131,0,"endonuclease 8-like 3 [Rattus norvegicus]","gi|281332205|ref|NM_001170346.1|",1883,0,"Rattus norvegicus nei-like DNA glycosylase 3 (Neil3), mRNA","Q8K203",1031,0,"Endonuclease 8-like 3","Rv3297",75.1,{"v":5e-14,"d":"5.00E-14"},"COG0266","pfam06839","zf-GRF","GRF zinc finger. This presumed zinc binding domain is found in a variety of DNA-binding proteins. It seems likely that this domain is involved in nucleic acid binding. It is named GRF after three conserved residues in the centre of the alignment of the domain. This zinc finger may be related to pfam01396.","GO:0006284|base-excision repair;","GO:0005634|nucleus;GO:0005654|nucleoplasm;","GO:0000405|bubble DNA binding;GO:0003684|damaged DNA binding;GO:0003690|double-stranded DNA binding;GO:0003697|single-stranded DNA binding;GO:0003906|DNA-(apurinic or apyrimidinic site) endonuclease activity;GO:0008270|zinc ion binding;GO:0019104|DNA N-glycosylase activity;GO:0140078|class I DNA-(apurinic or apyrimidinic site) endonuclease activity;","K10569","NEIL3; endonuclease VIII-like 3"]
["ENSRNOG00000017786",5,0.420676343,21,1.350939202,0.311395467,-1.683180153,0.007985103,0.005155657,"down","yes","Acta1","protein_coding","chr19:51883715-51886742:-","gi|625184696|ref|XP_007651673.1|",2064,0,"PREDICTED: actin, alpha skeletal muscle [Cricetulus griseus]","gi|298892557|emb|FQ215282.1|",1445,0,"Rattus norvegicus TL0ACA48YN09 mRNA sequence","P68136",790,0,"Actin, alpha skeletal muscle","SPBC32H8.12c",711,0,"COG5277","pfam00022","Actin","Actin.","GO:0009612|response to mechanical stimulus;GO:0009991|response to extracellular stimulus;GO:0010226|response to lithium ion;GO:0010628|positive regulation of gene expression;GO:0030240|skeletal muscle thin filament assembly;GO:0043503|skeletal muscle fiber adaptation;GO:0048545|response to steroid hormone;GO:0048741|skeletal muscle fiber development;GO:0071417|cellular response to organonitrogen compound;GO:0090131|mesenchyme migration;","GO:0001725|stress fiber;GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005865|striated muscle thin filament;GO:0005869|dynactin complex;GO:0005884|actin filament;GO:0015629|actin cytoskeleton;GO:0030017|sarcomere;GO:0030027|lamellipodium;GO:0030175|filopodium;GO:0044297|cell body;","GO:0005524|ATP binding;","K10354","ACTA1; actin, alpha skeletal muscle"]
["ENSRNOG00000039086",5,0.420676343,21,1.350939202,0.311395467,-1.683180153,0.007985103,0.005155657,"down","yes","Ccdc153","protein_coding","chr8:44577836-44584338:+","gi|62078635|ref|NP_001013975.1|",759,{"v":2E-95,"d":"2.00E-95"},"coiled-coil domain-containing protein 153 [Rattus norvegicus]","gi|62078634|ref|NM_001013953.1|",1362,0,"Rattus norvegicus coiled-coil domain containing 153 (Ccdc153), mRNA",".",".",".",".",".",".",".",".","pfam04012","PspA_IM30","PspA/IM30 family. This family includes PspA a protein that suppresses sigma54-dependent transcription. The PspA protein, a negative regulator of the Escherichia coli phage shock psp operon, is produced when virulence factors are exported through secretins in many Gram-negative pathogenic bacteria and its homologue in plants, VIPP1, plays a critical role in thylakoid biogenesis, essential for photosynthesis. Activation of transcription by the enhancer-dependent bacterial sigma(54) containing RNA polymerase occurs through ATP hydrolysis-driven protein conformational changes enabled by activator proteins that belong to the large AAA(+) mechanochemical protein family. It has been shown that PspA directly and specifically acts upon and binds to the AAA(+) domain of the PspF transcription activator.",".",".","GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000009610",17,1.430299567,45,2.894869718,0.494080807,-1.01718108,0.008444852,5.428039E-3,"down","yes","ENSRNOG00000009610","protein_coding","chr2:179135796-179138202:+","gi|149033027|gb|EDL87856.1|",3005,0,"rCG40952 [Rattus norvegicus]","gi|672043340|ref|XR_145852.3|",1777,0,"PREDICTED: Rattus norvegicus trichohyalin-like 1 (Tchhl1), misc_RNA","Q9D3P1",863,0,"Trichohyalin-like protein 1",".",".",".",".","pfam01023","S_100","S-100/ICaBP type calcium binding domain. The S-100 domain is a subfamily of the EF-hand calcium binding proteins.",".",".","GO:0005509|calcium ion binding;GO:0046914|transition metal ion binding;",".","."]
["ENSRNOG00000064552",17,1.430299567,45,2.894869718,0.494080807,-1.01718108,0.008444852,5.428039E-3,"down","yes","ENSRNOG00000064552","lncRNA","chr1:230966740-231036628:+",".",".",".",".","gi|672014785|ref|XR_599219.1|",686,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102548095 (LOC102548095), transcript variant X1, ncRNA",".",".",".",".",".",".",".",".","pfam05604","DUF776","Protein of unknown function (DUF776). This family consists of several highly related mouse and human proteins of unknown function.",".",".",".",".","."]
["ENSRNOG00000065614",17,1.430299567,45,2.894869718,0.494080807,-1.01718108,0.008444852,5.428039E-3,"down","yes","ENSRNOG00000065614","lncRNA","chr16:65910062-65914039:+","gi|148701441|gb|EDL33388.1|",115,6E-9,"mCG1045525, partial [Mus musculus]","gi|78675906|gb|AC154102.15|",589,0,"Mus musculus chromosome 8, clone RP24-186O14, complete sequence",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["ENSRNOG00000009153",3,0.252405806,16,1.029287011,0.24522393,-2.027828325,0.008592498,0.005514478,"down","yes","Cidec","protein_coding","chr4:146569289-146582173:-","gi|348605174|ref|NP_001019504.2|",1177,{"v":1E-153,"d":"1.00E-153"},"cell death activator CIDE-3 isoform 1 [Rattus norvegicus]","gi|348605177|ref|NM_001244798.1|",1539,0,"Rattus norvegicus cell death-inducing DFFA-like effector c (Cidec), transcript variant 3, mRNA","Q5XI33",453,{"v":1E-153,"d":"1.00E-153"},"Cell death activator CIDE-3",".",".",".",".","pfam02017","CIDE-N","CIDE-N domain. This domain is found in CAD nuclease, and in ICAD, the inhibitor of CAD nuclease. The two proteins interact through this domain.","GO:0006915|apoptotic process;GO:0034389|lipid droplet organization;GO:0042981|regulation of apoptotic process;GO:0097194|execution phase of apoptosis;","GO:0005634|nucleus;GO:0005783|endoplasmic reticulum;GO:0005811|lipid droplet;GO:0005829|cytosol;",".",".","."]
["ENSRNOG00000015408",3,0.252405806,16,1.029287011,0.24522393,-2.027828325,0.008592498,0.005514478,"down","yes","Vil1","protein_coding","chr9:75991141-76018858:+","gi|157817658|ref|NP_001101694.1|",4268,0,"villin-1 [Rattus norvegicus]","gi|197927351|ref|NM_001108224.2|",3301,0,"Rattus norvegicus villin 1 (Vil1), mRNA","Q62468",1593,0,"Villin-1",".",".",".",".","pfam00626","Gelsolin","Gelsolin repeat.","GO:0001951|intestinal D-glucose absorption;GO:0006915|apoptotic process;GO:0007173|epidermal growth factor receptor signaling pathway;GO:0008150|biological_process;GO:0008154|actin polymerization or depolymerization;GO:0008360|regulation of cell shape;GO:0009617|response to bacterium;GO:0010634|positive regulation of epithelial cell migration;GO:0030041|actin filament polymerization;GO:0030042|actin filament depolymerization;GO:0030335|positive regulation of cell migration;GO:0030836|positive regulation of actin filament depolymerization;GO:0030855|epithelial cell differentiation;GO:0032233|positive regulation of actin filament bundle assembly;GO:0032532|regulation of microvillus length;GO:0035729|cellular response to hepatocyte growth factor stimulus;GO:0040018|positive regulation of multicellular organism growth;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045010|actin nucleation;GO:0051014|actin filament severing;GO:0051016|barbed-end actin filament capping;GO:0051125|regulation of actin nucleation;GO:0051693|actin filament capping;GO:0060327|cytoplasmic actin-based contraction involved in cell motility;GO:0061041|regulation of wound healing;GO:0071364|cellular response to epidermal growth factor stimulus;GO:1902896|terminal web assembly;GO:1903078|positive regulation of protein localization to plasma membrane;GO:2000392|regulation of lamellipodium morphogenesis;GO:2000394|positive regulation of lamellipodium morphogenesis;","GO:0001726|ruffle;GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005902|microvillus;GO:0005903|brush border;GO:0015629|actin cytoskeleton;GO:0030027|lamellipodium;GO:0030175|filopodium;GO:0032432|actin filament bundle;GO:0032433|filopodium tip;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0035727|lysophosphatidic acid binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0043027|cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0051015|actin filament binding;","K05761","VIL1; villin 1"]
["ENSRNOG00000066846",3,0.252405806,16,1.029287011,0.24522393,-2.027828325,0.008592498,0.005514478,"down","yes","ENSRNOG00000066846","lncRNA","chr6:31355072-31362028:-",".",".",".",".","gi|77020598|gb|AC117236.4|",703,0,"Mus musculus BAC clone RP23-416K18 from chromosome 12, complete sequence",".",".",".",".",".",".",".",".","pfam05109","Herpes_BLLF1","Herpes virus major outer envelope glycoprotein (BLLF1). This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralizing antibodies in vivo.",".",".",".",".","."]
["ENSRNOG00000029520",6,0.504811612,23,1.479600078,0.34118112,-1.551390281,0.008847607,0.005662183,"down","yes","AC110315.1","protein_coding","chr15:50452312-50455724:-","gi|392333351|ref|XP_003752869.1|",2995,0,"PREDICTED: N-acetyltransferase ESCO2 [Rattus norvegicus]","gi|959093034|ref|NG_046220.1|",3413,0,"Rattus norvegicus establishment of cohesion 1 homolog 2 (S. cerevisiae), pseudogene 2 (Esco2-ps2) on chromosome 15","Q8CIB9",967,0,"N-acetyltransferase ESCO2",".",".",".",".","pfam13880","Acetyltransf_13","ESCO1/2 acetyl-transferase.",".",".",".",".","."]
["ENSRNOG00000043103",6,0.504811612,23,1.479600078,0.34118112,-1.551390281,0.008847607,0.005662183,"down","yes","Frrs1l","protein_coding","chr5:71659284-71690108:-","gi|442580969|sp|D3ZE85.1|FRS1L_RAT",1380,{"v":3e-179,"d":"3.00E-179"},"RecName: Full=DOMON domain-containing protein FRRS1L; AltName: Full=Ferric-chelate reductase 1-like protein; Flags: Precursor","gi|672052704|ref|XM_345535.8|",3257,0,"PREDICTED: Rattus norvegicus ferric-chelate reductase 1-like (Frrs1l), transcript variant X2, mRNA","D3ZE85",536,{"v":1E-180,"d":"1.00E-180"},"DOMON domain-containing protein FRRS1L",".",".",".",".","pfam03351","DOMON","DOMON domain. The DOMON (named after dopamine beta-monooxygenase N-terminal) domain is 110-125 residues long. It is predicted to form an all beta fold with up to 11 strands and is secreted to the extracellular compartment. The beta-strand folding produces a hydrophobic pocket which appears to bind soluble haem. This is consistent with the predominant architectures where the protein is associated with cytochromes or enzymatic domains whose activity involves redox or electron transfer reactions potentially as a direct participant in the electron transfer process. The DOMON domain superfamily, of which this is just one member, shows (1) multiple hydrophobic residues that contribute to the hydrophobic core of the strands of the beta-sandwich, and small residues found at the boundaries of strands and loops, (2) a strongly conserved charged residue (usually arginine/lysine) at the end of strand 9, which possibly stabilizes the loop between 9 and 10, and (3) a polar residue (usually histidine, lysine or arginine), that interacts or coordinates with ligands. The suggested superfamily includes both haem- and sugar-binding members: the haem-binding families being the ethyl-Benzoate dehydrogenase family EB_dh, pfam09459, the cellobiose dehydrogenase family CBDH and this family, and the sugar-binding families being the xylanases, CBM_4_9, pfam02018. The common feature of the superfamily is the 11-beta-strand structure, although the first and eleventh strands are not well conserved either within families or between families.","GO:0099072|regulation of postsynaptic membrane neurotransmitter receptor levels;GO:1900449|regulation of glutamate receptor signaling pathway;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0045202|synapse;",".","K25381","FRRS1L; DOMON domain-contaning protein FRRS1L"]
["ENSRNOG00000070845",6,0.504811612,23,1.479600078,0.34118112,-1.551390281,0.008847607,0.005662183,"down","yes","ENSRNOG00000070845","lncRNA","chr4:125689911-125697538:-",".",".",".",".","gi|672018575|ref|XR_345989.2|",288,{"v":3e-147,"d":"3.00E-147"},"PREDICTED: Rattus norvegicus uncharacterized LOC102555860 (LOC102555860), ncRNA",".",".",".",".",".",".",".",".","pfam00606","Glycoprotein_B","Herpesvirus Glycoprotein B. This family of proteins contains a transmembrane region.",".",".",".",".","."]
["ENSRNOG00000022748",14,1.177893761,39,2.508887089,0.46948855,-1.090838122,0.009429302,0.006006915,"down","yes","Tmem126a","protein_coding","chr1:144422703-144430628:-","gi|58585236|ref|NP_001011557.1|",1020,{"v":3e-127,"d":"3.00E-127"},"transmembrane protein 126A [Rattus norvegicus]","gi|58585235|ref|NM_001011557.1|",2418,0,"Rattus norvegicus transmembrane protein 126A (Tmem126a), mRNA","Q5HZA9",397,{"v":1e-128,"d":"1.00E-128"},"Transmembrane protein 126A",".",".",".",".","pfam07114","DUF1370","Protein of unknown function (DUF1370). This family consists of several hypothetical eukaryotic proteins of around 200 residues in length. Members of this family seem to be specific to mammals and their function is unknown.","GO:0008150|biological_process;GO:0021554|optic nerve development;GO:0032981|mitochondrial respiratory chain complex I assembly;","GO:0005575|cellular_component;GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;","K18157","TMEM126A; transmembrane protein 126A"]
["ENSRNOG00000000368",7,0.588946881,25,1.608260955,0.366201069,-1.449292093,0.009452816,0.006019781,"down","yes","Grik2","protein_coding","chr20:52133851-52838375:-","gi|3287965|sp|P42260.2|GRIK2_RAT",4799,0,"RecName: Full=Glutamate receptor ionotropic, kainate 2; Short=GluK2; AltName: Full=Glutamate receptor 6; Short=GluR-6; Short=GluR6; Flags: Precursor","gi|56281|emb|Z11548.1|",4498,0,"R.norvegicus cDNA for glutamate receptor subunit (GluR6), kainate subtype","P42260",1853,0,"Glutamate receptor ionotropic, kainate 2",".",".",".",".","pfam00060","Lig_chan","Ligand-gated ion channel. This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.","GO:0001662|behavioral fear response;GO:0006874|cellular calcium ion homeostasis;GO:0006886|intracellular protein transport;GO:0007268|chemical synaptic transmission;GO:0019228|neuronal action potential;GO:0034220|ion transmembrane transport;GO:0035235|ionotropic glutamate receptor signaling pathway;GO:0035249|synaptic transmission, glutamatergic;GO:0042391|regulation of membrane potential;GO:0043113|receptor clustering;GO:0043524|negative regulation of neuron apoptotic process;GO:0043525|positive regulation of neuron apoptotic process;GO:0046328|regulation of JNK cascade;GO:0048169|regulation of long-term neuronal synaptic plasticity;GO:0048172|regulation of short-term neuronal synaptic plasticity;GO:0050804|modulation of chemical synaptic transmission;GO:0050806|positive regulation of synaptic transmission;GO:0051402|neuron apoptotic process;GO:0051967|negative regulation of synaptic transmission, glutamatergic;GO:0060079|excitatory postsynaptic potential;GO:0060080|inhibitory postsynaptic potential;GO:0099505|regulation of presynaptic membrane potential;GO:0120169|detection of cold stimulus involved in thermoception;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0008328|ionotropic glutamate receptor complex;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0032839|dendrite cytoplasm;GO:0032983|kainate selective glutamate receptor complex;GO:0042734|presynaptic membrane;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0043204|perikaryon;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0098686|hippocampal mossy fiber to CA3 synapse;GO:0098978|glutamatergic synapse;","GO:0004970|ionotropic glutamate receptor activity;GO:0005234|extracellularly glutamate-gated ion channel activity;GO:0005515|protein binding;GO:0008066|glutamate receptor activity;GO:0015276|ligand-gated ion channel activity;GO:0015277|kainate selective glutamate receptor activity;GO:0030165|PDZ domain binding;GO:0031624|ubiquitin conjugating enzyme binding;GO:0031625|ubiquitin protein ligase binding;GO:0038023|signaling receptor activity;GO:0042802|identical protein binding;GO:0099507|ligand-gated ion channel activity involved in regulation of presynaptic membrane potential;GO:1904315|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K05202","GRIK2; glutamate receptor, ionotropic kainate 2"]
["ENSRNOG00000047002",7,0.588946881,25,1.608260955,0.366201069,-1.449292093,0.009452816,0.006019781,"down","yes","Fstl5","protein_coding","chr2:160856291-161526589:+","gi|403225027|ref|NP_001258124.1|",4560,0,"follistatin-related protein 5 precursor [Rattus norvegicus]","gi|403225026|ref|NM_001271195.1|",5084,0,"Rattus norvegicus follistatin-like 5 (Fstl5), mRNA","Q8BFR2",1718,0,"Follistatin-related protein 5",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0007275|multicellular organism development;GO:0030154|cell differentiation;","GO:0005576|extracellular region;","GO:0005509|calcium ion binding;","K23915","FSTL5; follistatin-related protein 5"]
["ENSRNOG00000055020",7,0.588946881,25,1.608260955,0.366201069,-1.449292093,0.009452816,0.006019781,"down","yes","ENSRNOG00000055020","pseudogene","chr1:39601959-39603122:-","gi|507640871|ref|XP_004701506.1|",986,{"v":8e-129,"d":"8.00E-129"},"PREDICTED: heterogeneous nuclear ribonucleoprotein A3 isoform X3 [Echinops telfairi]","gi|34333453|gb|AY363226.1|",1125,0,"Rattus norvegicus heterogeneous nuclear ribonucleoprotein A3 variant a mRNA, complete cds; alternatively spliced","P51991",371,{"v":2e-124,"d":"2.00E-124"},"Heterogeneous nuclear ribonucleoprotein A3",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.",".",".",".",".","."]
["ENSRNOG00000025065",13,1.093758492,37,2.380226213,0.459518716,-1.121804473,0.009695417,0.006152687,"down","yes","RGD1560436","protein_coding","chr5:137198720-137204026:+","gi|157824166|ref|NP_001102734.1|",1112,{"v":7e-150,"d":"7.00E-150"},"uncharacterized protein C1orf109 homolog [Rattus norvegicus]","gi|157824165|ref|NM_001109264.1|",1083,0,"Rattus norvegicus similar to hypothetical protein FLJ20508 (RGD1560436), mRNA","Q499E6",374,{"v":1e-128,"d":"1.00E-128"},"Uncharacterized protein C1orf109 homolog",".",".",".",".","pfam15011","CK2S","Casein Kinase 2 substrate. It is suggested that CK2S (C10orf109) is important in the regulation of cancer cell proliferation. Studies have indicated that CK2S is the downstream target of a protein kinase, casein kinase 2 (CK2), which is upregulated in cancer cells. CK2S has been found to be upregulated in cancer cells. The precise mechanism of CK2 targetting CK2S is not well characterized. It is found to be localized in the nucleus and cytoplasm. This family of proteins is found in eukaryotes. Proteins in this family are typically between 160 and 221 amino acids in length. There is a single completely conserved residue P that may be functionally important.",".","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005829|cytosol;",".",".","."]
["ENSRNOG00000060021",13,1.093758492,37,2.380226213,0.459518716,-1.121804473,0.009695417,0.006152687,"down","yes","Txlnb","protein_coding","chr1:12404859-12449975:+","gi|209529675|ref|NP_001129331.1|",2980,0,"beta-taxilin [Rattus norvegicus]","gi|209529674|ref|NM_001135859.1|",4044,0,"Rattus norvegicus taxilin beta (Txlnb), mRNA","Q8VBT1",927,0,"Beta-taxilin",".",".",".",".","pfam09728","Taxilin","Myosin-like coiled-coil protein. Taxilin contains an extraordinarily long coiled-coil domain in its C-terminal half and is ubiquitously expressed. It is a novel binding partner of several syntaxin family members and is possibly involved in Ca2+-dependent exocytosis in neuroendocrine cells. Gamma-taxilin, described as leucine zipper protein Factor Inhibiting ATF4-mediated Transcription (FIAT), localizes to the nucleus in osteoblasts and dimerises with ATF4 to form inactive dimers, thus inhibiting ATF4-mediated transcription.",".","GO:0005737|cytoplasm;","GO:0019905|syntaxin binding;",".","."]
["ENSRNOG00000052665",8,0.673082149,27,1.736921831,0.387514359,-1.367678327,0.009839673,0.006234784,"down","yes","Onecut2","protein_coding","chr18:57832111-57879629:+","gi|119220568|ref|NP_919244.2|",2066,0,"one cut domain family member 2 [Mus musculus]","gi|672083727|ref|XM_008772203.1|",2063,0,"PREDICTED: Rattus norvegicus one cut homeobox 2 (Onecut2), transcript variant X2, mRNA","Q6XBJ3",800,0,"One cut domain family member 2",".",".",".",".","pfam02376","CUT","CUT domain. The CUT domain is a DNA-binding motif which can bind independently or in cooperation with the homeodomain, often found downstream of the CUT domain. Multiple copies of the CUT domain can exist in one protein.","GO:0001889|liver development;GO:0001952|regulation of cell-matrix adhesion;GO:0002064|epithelial cell development;GO:0009653|anatomical structure morphogenesis;GO:0030335|positive regulation of cell migration;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0031016|pancreas development;GO:0031018|endocrine pancreas development;GO:0045165|cell fate commitment;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048935|peripheral nervous system neuron development;GO:0060271|cilium assembly;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0015629|actin cytoskeleton;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:1990837|sequence-specific double-stranded DNA binding;","K24170","ONECUT2; one cut domain family member 2"]
["ENSRNOG00000011562",12,1.009623224,35,2.251565336,0.448409472,-1.157111341,0.0099093,0.006273792,"down","yes","Slitrk2","protein_coding","chrX:145246460-145271220:+","gi|157821187|ref|NP_001101057.1|",4104,0,"SLIT and NTRK-like protein 2 precursor [Rattus norvegicus]","gi|672088797|ref|XM_006257626.2|",7732,0,"PREDICTED: Rattus norvegicus SLIT and NTRK-like family, member 2 (Slitrk2), transcript variant X2, mRNA","Q810C0",1566,0,"SLIT and NTRK-like protein 2",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.","GO:0007409|axonogenesis;GO:0050807|regulation of synapse organization;GO:0051965|positive regulation of synapse assembly;GO:0099560|synaptic membrane adhesion;GO:1905606|regulation of presynapse assembly;","GO:0098978|glutamatergic synapse;GO:0098982|GABA-ergic synapse;GO:0099055|integral component of postsynaptic membrane;",".",".","."]
["ENSRNOG00000024190",12,1.009623224,35,2.251565336,0.448409472,-1.157111341,0.0099093,0.006273792,"down","yes","Rasef","protein_coding","chr5:87548908-87619031:-","gi|474451689|ref|NP_001264263.1|",3596,0,"ras and EF-hand domain-containing protein [Rattus norvegicus]","gi|474451688|ref|NM_001277334.1|",2405,0,"Rattus norvegicus RAS and EF hand domain containing (Rasef), mRNA","Q8IZ41",1066,0,"Ras and EF-hand domain-containing protein",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.",".","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0048471|perinuclear region of cytoplasm;","GO:0003924|GTPase activity;GO:0005509|calcium ion binding;GO:0005525|GTP binding;GO:0019003|GDP binding;GO:0042802|identical protein binding;","K17199","RASEF, RAB45; Ras and EF-hand domain-containing protein"]
["ENSRNOG00000061658",12,1.009623224,35,2.251565336,0.448409472,-1.157111341,0.0099093,0.006273792,"down","yes","U4","snRNA","chr11:32846065-32846217:+",".",".",".",".","gi|87080561|emb|CT573085.6|",51,{"v":2E-16,"d":"2.00E-16"},"Mouse DNA sequence from clone RP23-436A20 on chromosome 13, complete sequence",".",".",".",".",".",".",".",".","pfam02525","Flavodoxin_2","Flavodoxin-like fold. This family consists of a domain with a flavodoxin-like fold. The family includes bacterial and eukaryotic NAD(P)H dehydrogenase (quinone) EC:1.6.99.2. These enzymes catalyse the NAD(P)H-dependent two-electron reductions of quinones and protect cells against damage by free radicals and reactive oxygen species.  This enzyme uses a FAD co-factor. The equation for this reaction is:- NAD(P)H + acceptor <=> NAD(P)(+) + reduced acceptor. This enzyme is also involved in the bioactivation of prodrugs used in chemotherapy. The family also includes acyl carrier protein phosphodiesterase EC:3.1.4.14. This enzyme converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine residue from ACP. This family is related to pfam03358 and pfam00258.",".",".",".",".","."]
["ENSRNOG00000025117",9,0.757217418,29,1.865582707,0.405887884,-1.300846819,0.010046503,0.006344838,"down","yes","Noxo1","protein_coding","chr10:13721473-13726061:+","gi|564370938|ref|XP_006246010.1|",1556,0,"PREDICTED: NADPH oxidase organizer 1 isoform X1 [Rattus norvegicus]","gi|672066855|ref|XM_008767566.1|",1330,0,"PREDICTED: Rattus norvegicus NADPH oxidase organizer 1 (Noxo1), transcript variant X1, mRNA","Q8VCM2",529,0,"NADPH oxidase organizer 1",".",".",".",".","pfam00018","SH3_1","SH3 domain. SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta barrel.","GO:0006801|superoxide metabolic process;GO:0022617|extracellular matrix disassembly;GO:0042554|superoxide anion generation;GO:0050790|regulation of catalytic activity;","GO:0005737|cytoplasm;GO:0043020|NADPH oxidase complex;","GO:0016176|superoxide-generating NADPH oxidase activator activity;GO:0019899|enzyme binding;GO:0035091|phosphatidylinositol binding;","K17934","NOXO1, SNX28; NADPH oxidase organizer 1"]
["ENSRNOG00000047682",9,0.757217418,29,1.865582707,0.405887884,-1.300846819,0.010046503,0.006344838,"down","yes","AABR07065031.1","protein_coding","chr6:101256172-101265662:-","gi|672020940|ref|XP_008774512.1|",3897,0,"PREDICTED: disintegrin and metalloproteinase domain-containing protein 21 [Rattus norvegicus]","gi|672056892|ref|XM_008764883.1|",2623,0,"PREDICTED: Rattus norvegicus disintegrin and metalloproteinase domain-containing protein 21-like (LOC103690152), mRNA","Q9JI76",1303,0,"Disintegrin and metalloproteinase domain-containing protein 21",".",".",".",".","pfam01421","Reprolysin","Reprolysin (M12B) family zinc metalloprotease. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as human ADAM8 and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.",".",".",".",".","."]
["ENSRNOG00000010280",11,0.925487955,33,2.12290446,0.435953653,-1.197753326,0.010053769,0.006344838,"down","yes","Pde8b","protein_coding","chr2:26276635-26509209:-","gi|672041232|ref|XP_008758892.1|",4744,0,"PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X3 [Rattus norvegicus]","gi|672041231|ref|XM_008760670.1|",3049,0,"PREDICTED: Rattus norvegicus phosphodiesterase 8B (Pde8b), transcript variant X3, mRNA","E9Q4S1",1768,0,"High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B",".",".",".",".","pfam00233","PDEase_I","3'5'-cyclic nucleotide phosphodiesterase.","GO:0001662|behavioral fear response;GO:0006198|cAMP catabolic process;GO:0007165|signal transduction;GO:0008542|visual learning;GO:0035106|operant conditioning;GO:0046676|negative regulation of insulin secretion;GO:0050885|neuromuscular process controlling balance;GO:0061179|negative regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0090032|negative regulation of steroid hormone biosynthetic process;","GO:0005575|cellular_component;","GO:0003674|molecular_function;GO:0004114|3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0004115|3',5'-cyclic-AMP phosphodiesterase activity;GO:0046872|metal ion binding;","K18437","PDE8; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 [EC:3.1.4.53]"]
["ENSRNOG00000024922",11,0.925487955,33,2.12290446,0.435953653,-1.197753326,0.010053769,0.006344838,"down","yes","Fbxo24","protein_coding","chr12:19072716-19083067:+","gi|254553399|ref|NP_001100600.2|",2918,0,"F-box only protein 24 [Rattus norvegicus]","gi|672072649|ref|XM_008769136.1|",2095,0,"PREDICTED: Rattus norvegicus F-box protein 24 (Fbxo24), transcript variant X2, mRNA","Q9D417",1059,0,"F-box only protein 24",".",".",".",".","pfam00415","RCC1","Regulator of chromosome condensation (RCC1) repeat.",".",".",".","K10304","FBXO24; F-box protein 24"]
["ENSRNOG00000032180",11,0.925487955,33,2.12290446,0.435953653,-1.197753326,0.010053769,0.006344838,"down","yes","Ccdc15","protein_coding","chr8:36998867-37068919:-","gi|672022700|ref|XP_006226429.2|",3735,0,"PREDICTED: coiled-coil domain-containing protein 15 isoform X1 [Rattus norvegicus]","gi|672022703|ref|XM_006226366.2|",3133,0,"PREDICTED: Rattus norvegicus coiled-coil domain containing 15 (Ccdc15), transcript variant X3, mRNA","Q8C9M2",1083,0,"Coiled-coil domain-containing protein 15",".",".",".",".","pfam13868","Trichoplein","tumor suppressor, Mitostatin. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs).",".","GO:0005813|centrosome;",".","K16752","CCDC15; coiled-coil domain-containing protein 15"]
["ENSRNOG00000063014",10,0.841352686,31,1.994243584,0.421890632,-1.245059041,0.010107903,0.006372117,"down","yes","ENSRNOG00000063014","lncRNA","chr1:165193809-165239593:-","gi|148685065|gb|EDL17012.1|",158,{"v":2E-14,"d":"2.00E-14"},"mCG145280, partial [Mus musculus]","gi|672014135|ref|XR_599003.1|",1441,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103691207 (LOC103691207), ncRNA",".",".",".",".",".",".",".",".","pfam15461","BCD","Beta-carotene 15,15'-dioxygenase. BCD is a family of bacterial and archaeal proteins is found in bacteria and archaea that catalyse or regulate the conversion of beta-carotene to retinal. Characterisation of BCD proteins shows them to cleave beta-carotene at its central double bond (15,15###) to yield two molecules of all-trans-retinal. However, the oxygen atom of retinal originated not from water but from molecular oxygen, suggesting that the enzyme was a beta-carotene 15,15###-dioxygenase, rather than a mono-oxygenase that catalyzes the same biochemical reaction.",".",".",".",".","."]
["ENSRNOG00000008356",2,0.168270537,13,0.836295696,0.201209378,-2.313230543,0.010119721,0.006375877,"down","yes","Myo5c","protein_coding","chr8:75989528-76066483:+","gi|564310298|ref|XP_006226541.1|",9405,0,"PREDICTED: unconventional myosin-Vc isoform X1 [Rattus norvegicus]","gi|672023077|ref|XM_006226479.2|",6637,0,"PREDICTED: Rattus norvegicus myosin VC (Myo5c), transcript variant X1, mRNA","Q9NQX4",3247,0,"Unconventional myosin-Vc","YOR326w",786,0,"COG5022","pfam00063","Myosin_head","Myosin head (motor domain).","GO:0007015|actin filament organization;GO:0030050|vesicle transport along actin filament;","GO:0005737|cytoplasm;GO:0015629|actin cytoskeleton;GO:0016459|myosin complex;GO:0031982|vesicle;","GO:0000146|microfilament motor activity;GO:0005524|ATP binding;GO:0051015|actin filament binding;","K10357","MYO5; myosin V"]
["ENSRNOG00000013372",2,0.168270537,13,0.836295696,0.201209378,-2.313230543,0.010119721,0.006375877,"down","yes","Shisal2b","protein_coding","chr2:36002651-36019123:-","gi|672015373|ref|XP_001072885.2|",720,{"v":7e-93,"d":"7.00E-93"},"PREDICTED: membrane protein FAM159B [Rattus norvegicus]","gi|672015372|ref|XM_001072885.5|",535,0,"PREDICTED: Rattus norvegicus family with sequence similarity 159, member B (Fam159b), mRNA","Q9D1Y9",253,{"v":1E-84,"d":"1.00E-84"},"Protein shisa-like-2B",".",".",".",".","pfam13908","Shisa","Wnt and FGF inhibitory regulator. Shisa is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000018853",2,0.168270537,13,0.836295696,0.201209378,-2.313230543,0.010119721,0.006375877,"down","yes","Slc28a3","protein_coding","chr17:6062549-6114038:+","gi|672080833|ref|XP_008769644.1|",3530,0,"PREDICTED: solute carrier family 28 member 3 isoform X1 [Rattus norvegicus]","gi|672080832|ref|XM_008771422.1|",2470,0,"PREDICTED: Rattus norvegicus solute carrier family 28 (concentrative nucleoside transporter), member 3 (Slc28a3), transcript variant X1, mRNA","Q8VIH3",1335,0,"Solute carrier family 28 member 3","all0378",306,{"v":3e-92,"d":"3.00E-92"},"COG1972","pfam07662","Nucleos_tra2_C","Na+ dependent nucleoside transporter C-terminus. This family consists of nucleoside transport proteins. Members include a purine-specific Na+-nucleoside cotransporter localized to the bile canalicular membrane and a Na+-dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine, which also transports the anti-viral nucleoside analogues AZT and ddC. This alignment covers the C-terminus of this family of transporters.","GO:0001895|retina homeostasis;GO:0015855|pyrimidine nucleobase transport;GO:0015860|purine nucleoside transmembrane transport;GO:0015862|uridine transport;GO:0015864|pyrimidine nucleoside transport;GO:0035725|sodium ion transmembrane transport;GO:0072531|pyrimidine-containing compound transmembrane transport;GO:1901642|nucleoside transmembrane transport;GO:1904823|purine nucleobase transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0031526|brush border membrane;","GO:0005337|nucleoside transmembrane transporter activity;GO:0005415|nucleoside:sodium symporter activity;GO:0015213|uridine transmembrane transporter activity;GO:0015293|symporter activity;GO:0015389|pyrimidine- and adenine-specific:sodium symporter activity;GO:0015390|purine-specific nucleoside:sodium symporter activity;","K11536","SLC28A; pyrimidine nucleoside transport protein"]
["ENSRNOG00000021091",2,0.168270537,13,0.836295696,0.201209378,-2.313230543,0.010119721,0.006375877,"down","yes","Trank1","protein_coding","chr8:111276354-111355092:+","gi|300796674|ref|NP_001178728.1|",15335,0,"TPR and ankyrin repeat-containing protein 1 [Rattus norvegicus]","gi|300796673|ref|NM_001191799.1|",8997,0,"Rattus norvegicus tetratricopeptide repeat and ankyrin repeat containing 1 (Trank1), mRNA",".",".",".",".",".",".",".",".","pfam13414","TPR_11","TPR repeat.",".",".",".",".","."]
["ENSRNOG00000033020",2,0.168270537,13,0.836295696,0.201209378,-2.313230543,0.010119721,0.006375877,"down","yes","Lcn1","protein_coding","chr3:9532915-9536577:+","gi|12621114|ref|NP_075234.1|",851,{"v":6e-114,"d":"6.00E-114"},"von Ebner gland protein 1 precursor [Rattus norvegicus]","gi|12621113|ref|NM_022945.1|",534,0,"Rattus norvegicus lipocalin 1 (Lcn1), mRNA","P20289",332,{"v":2e-115,"d":"2.00E-115"},"von Ebner gland protein 1",".",".",".",".","pfam00061","Lipocalin","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.","GO:0001895|retina homeostasis;GO:0050909|sensory perception of taste;","GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0005102|signaling receptor binding;GO:0008270|zinc ion binding;GO:0031404|chloride ion binding;GO:0036094|small molecule binding;","K25351","LCN1; lipocalin-1"]
["ENSRNOG00000006324",1,0.084135269,10,0.643304382,0.130786096,-2.93471892,0.010188395,0.006405802,"down","yes","ENSRNOG00000006324","protein_coding","chr8:5758935-5828092:+","gi|530719556|ref|NP_001269016.1|",1844,0,"short transient receptor potential channel 6 isoform 3 [Mus musculus]","gi|16758329|ref|NM_053559.1|",1125,0,"Rattus norvegicus transient receptor potential cation channel, subfamily C, member 6 (Trpc6), mRNA","Q61143",680,0,"Short transient receptor potential channel 6",".",".",".",".","pfam08344","TRP_2","Transient receptor ion channel II. This domain is found in the transient receptor ion channel (Trp) family of proteins. There is strong evidence that Trp proteins are structural elements of calcium-ion entry channels activated by G protein-coupled receptors. This domain does not tend to appear with the TRP domain (pfam06011) but is often found to the C-terminus of Ankyrin repeats (pfam00023).","GO:0006828|manganese ion transport;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007338|single fertilization;GO:0007568|aging;GO:0010800|positive regulation of peptidyl-threonine phosphorylation;GO:0030182|neuron differentiation;GO:0032414|positive regulation of ion transmembrane transporter activity;GO:0045666|positive regulation of neuron differentiation;GO:0050774|negative regulation of dendrite morphogenesis;GO:0051480|regulation of cytosolic calcium ion concentration;GO:0051928|positive regulation of calcium ion transport;GO:0070301|cellular response to hydrogen peroxide;GO:0070588|calcium ion transmembrane transport;GO:0071456|cellular response to hypoxia;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0034703|cation channel complex;GO:0036057|slit diaphragm;","GO:0003779|actin binding;GO:0005216|ion channel activity;GO:0005261|cation channel activity;GO:0005262|calcium channel activity;GO:0005515|protein binding;GO:0015279|store-operated calcium channel activity;GO:0030276|clathrin binding;GO:0042803|protein homodimerization activity;GO:0042805|actinin binding;GO:0051117|ATPase binding;GO:0070679|inositol 1,4,5 trisphosphate binding;","K04969","TRPC6; transient receptor potential cation channel subfamily C member 6"]
["ENSRNOG00000021656",1,0.084135269,10,0.643304382,0.130786096,-2.93471892,0.010188395,0.006405802,"down","yes","RGD1359334","protein_coding","chr2:182814793-182818512:-","gi|56090341|ref|NP_001007639.1|",1382,0,"protein MENT precursor [Rattus norvegicus]","gi|56090340|ref|NM_001007638.1|",1218,0,"Rattus norvegicus similar to hypothetical protein FLJ20519 (RGD1359334), mRNA","Q5XI62",536,0,"Protein MENT",".",".",".",".","pfam15322","PMSI1","Protein missing in infertile sperm 1, putative. This family of proteins is found in eukaryotes. Proteins in this family are typically between 249 and 341 amino acids in length.","GO:0042127|regulation of cell proliferation;","GO:0005576|extracellular region;",".","K25382","MENT; protein MENT"]
["ENSRNOG00000035642",1,0.084135269,10,0.643304382,0.130786096,-2.93471892,0.010188395,0.006405802,"down","yes","Mirlet7i","miRNA","chr7:58642480-58642571:-",".",".",".",".","gi|927130315|ref|XM_013997682.1|",92,{"v":1e-39,"d":"1.00E-39"},"PREDICTED: Sus scrofa translation initiation factor IF-2-like (LOC106510317), mRNA",".",".",".",".",".",".",".",".","pfam12675","DUF3795","Protein of unknown function (DUF3795). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 99 and 171 amino acids in length. This protein is likely to be zinc binding given the conserved cysteines.","GO:0007569|cell aging;GO:0009617|response to bacterium;GO:0060291|long-term synaptic potentiation;GO:0071230|cellular response to amino acid stimulus;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0016442|RISC complex;",".","K16980","MIRLET7; microRNA let-7"]
["ENSRNOG00000047596",1,0.084135269,10,0.643304382,0.130786096,-2.93471892,0.010188395,0.006405802,"down","yes","AC118414.2","protein_coding","chr3:144519930-144524920:-","gi|672017621|ref|XP_008773812.1|",987,{"v":1e-132,"d":"1.00E-132"},"PREDICTED: uncharacterized protein C20orf173 homolog isoform X3 [Rattus norvegicus]","gi|672017620|ref|XM_008775590.1|",757,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102550306 (LOC102550306), transcript variant X4, mRNA",".",".",".",".",".",".",".",".","pfam05060","MGAT2","N-acetylglucosaminyltransferase II (MGAT2). UDP-N-acetyl-D-glucosamine:alpha-6-D-mannoside beta-1,2-N- acetylglucosaminyltransferase II (EC 2.4.1.143) (GnT II/MGAT2) is a Golgi resident enzyme that catalyses an essential step in the biosynthetic pathway leading from high mannose to complex N-linked oligosaccharides. Mutations in the MGAT2 gene lead to congenital disorder of glycosylation (CDG IIa). CDG IIa patients have an increased bleeding tendency, unrelated to coagulation factors.",".",".",".",".","."]
["ENSRNOG00000049523",1,0.084135269,10,0.643304382,0.130786096,-2.93471892,0.010188395,0.006405802,"down","yes","AC097153.2","pseudogene","chr2:5243284-5243809:+","gi|61557307|ref|NP_001013231.1|",551,{"v":6e-69,"d":"6.00E-69"},"centromere protein R [Rattus norvegicus]","gi|672053206|ref|XM_008763884.1|",243,{"v":1e-122,"d":"1.00E-122"},"PREDICTED: Rattus norvegicus integrin beta 3 binding protein (beta3-endonexin) (Itgb3bp), transcript variant X5, mRNA","Q5U1Z7",216,{"v":2E-70,"d":"2.00E-70"},"Centromere protein R",".",".",".",".","pfam06729","CENP-R","Kinetochore component, CENP-R. This family consists of mammalian kinetochore sub-complex proteins CENP-R, also referred to as nuclear receptor co-activator NRIF3 proteins. NRIF3 exhibits a distinct receptor specificity in interacting with and potentiating the activity of only TRs and RXRs but not other examined nuclear receptors. NRIF3 as a co-regulator that possesses both transactivation and transrepression domains and/or functions. Collectively, the NRIF3 family of co-regulators may play dual roles in mediating both positive and negative regulatory effects on gene expression. CENP-R is one of the 15 components that make up the constitutive centromere associated complex (CCAN) part of the kinetochore. A sub-complex of CCAN, consisting of CENP-P/O/R/Q/U self-assembles on kinetochores with varying stoichiometry and undergoes a pre-mitotic maturation step. Kinetochore assembly is a cell cycle regulated multi-step process. The initial step occurs during interphase and involves loading of the 15-subunit constitutive centromere associated complex (CCAN). Kinetochores are multi-protein megadalton assemblies that are required for attachment of microtubules to centromeres and, in turn, the segregation of chromosomes in mitosis.",".",".",".",".","."]
["ENSRNOG00000049827",1,0.084135269,10,0.643304382,0.130786096,-2.93471892,0.010188395,0.006405802,"down","yes","Arl14","protein_coding","chr2:153468977-153469555:+","gi|672015870|ref|XP_008773385.1|",1026,{"v":4e-140,"d":"4.00E-140"},"PREDICTED: ADP-ribosylation factor-like protein 14 [Rattus norvegicus]","gi|672015869|ref|XM_008775163.1|",579,0,"PREDICTED: Rattus norvegicus ADP-ribosylation factor-like 14 (Arl14), mRNA","Q3SXC5",375,{"v":5e-132,"d":"5.00E-132"},"ADP-ribosylation factor-like protein 14","YDL192w",157,{"v":4e-47,"d":"4.00E-47"},"COG1100","pfam00025","Arf","ADP-ribosylation factor family. Pfam combines a number of different Prosite families together","GO:0006886|intracellular protein transport;GO:0016192|vesicle-mediated transport;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;","GO:0003924|GTPase activity;GO:0005525|GTP binding;","K17200","ARL14, ARF7; ADP-ribosylation factor-like protein 14"]
["ENSRNOG00000053969",1,0.084135269,10,0.643304382,0.130786096,-2.93471892,0.010188395,0.006405802,"down","yes","AABR07008681.1","protein_coding","chr2:60024969-60032699:-","gi|68235767|gb|AAY88222.1|",1965,0,"nucleic acid binding protein [Rattus norvegicus]","gi|31455630|gb|AC096039.7|",1562,0,"Rattus norvegicus 4 BAC CH230-29I22 (Children's Hospital Oakland Research Institute) complete sequence","P11260",471,{"v":2E-159,"d":"2.00E-159"},"LINE-1 retrotransposable element ORF1 protein",".",".",".",".","pfam02994","Transposase_22","L1 transposable element.",".",".",".",".","."]
["ENSRNOG00000062445",1,0.084135269,10,0.643304382,0.130786096,-2.93471892,0.010188395,0.006405802,"down","yes","ENSRNOG00000062445","lncRNA","chrX:20871338-20873731:+",".",".",".",".","gi|29125266|emb|AL954855.8|",201,{"v":2E-99,"d":"2.00E-99"},"Mouse DNA sequence from clone RP23-211L10 on chromosome X, complete sequence",".",".",".",".",".",".",".",".","pfam01500","Keratin_B2","Keratin, high sulfur B2 protein. High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.",".",".",".",".","."]
["ENSRNOG00000062465",1,0.084135269,10,0.643304382,0.130786096,-2.93471892,0.010188395,0.006405802,"down","yes","ENSRNOG00000062465","protein_coding","chr14:97517407-97518328:+","gi|589958246|ref|XP_006991719.1|",774,{"v":9e-101,"d":"9.00E-101"},"PREDICTED: deoxycytidine kinase [Peromyscus maniculatus bairdii]","gi|298900663|emb|FQ212366.1|",320,{"v":2E-165,"d":"2.00E-165"},"Rattus norvegicus TL0AAA57YJ12 mRNA sequence","P43346",295,{"v":2E-99,"d":"2.00E-99"},"Deoxycytidine kinase",".",".",".",".","pfam01712","dNK","Deoxynucleoside kinase. This family consists of various deoxynucleoside kinases cytidine EC:2.7.1.74, guanosine EC:2.7.1.113, adenosine EC:2.7.1.76 and thymidine kinase EC:2.7.1.21 (which also phosphorylates deoxyuridine and deoxycytosine.) These enzymes catalyse the production of deoxynucleotide 5'-monophosphate from a deoxynucleoside. Using ATP and yielding ADP in the process.",".",".",".",".","."]
["ENSRNOG00000063476",1,0.084135269,10,0.643304382,0.130786096,-2.93471892,0.010188395,0.006405802,"down","yes","ENSRNOG00000063476","protein_coding","chr10:69780210-69790446:-","gi|293340312|ref|XP_001081104.2|",669,{"v":2E-78,"d":"2.00E-78"},"PREDICTED: zinc finger HIT domain-containing protein 3 [Rattus norvegicus]","gi|672068866|ref|XM_008768098.1|",1255,0,"PREDICTED: Rattus norvegicus myosin XIX (Myo19), transcript variant X1, mRNA","Q9CQK1",219,{"v":2e-64,"d":"2.00E-64"},"Zinc finger HIT domain-containing protein 3",".",".",".",".","pfam01064","Activin_recp","Activin types I and II receptor domain. This Pfam entry consists of both TGF-beta receptor types. This is an alignment of the hydrophilic cysteine-rich ligand-binding domains, Both receptor types, (type I and II) posses a 9 amino acid cysteine box, with the the consensus CCX{4-5}CN. The type I receptors also possess 7 extracellular residues preceding the cysteine box.",".",".",".",".","."]
["ENSRNOG00000064017",1,0.084135269,10,0.643304382,0.130786096,-2.93471892,0.010188395,0.006405802,"down","yes","ENSRNOG00000064017","lncRNA","chr9:111386455-111398868:+","gi|293349986|ref|XP_001056555.2|",342,{"v":7e-31,"d":"7.00E-31"},"PREDICTED: structural maintenance of chromosomes flexible hinge domain-containing protein 1 isoform X1 [Rattus norvegicus]","gi|39930807|gb|AC107664.8|",542,0,"Mus musculus chromosome 17, clone RP23-103F2, complete sequence","Q6P5D8",115,{"v":7e-26,"d":"7.00E-26"},"Structural maintenance of chromosomes flexible hinge domain-containing protein 1",".",".",".",".","pfam03152","UFD1","Ubiquitin fusion degradation protein UFD1. Post-translational ubiquitin-protein conjugates are recognized for degradation by the ubiquitin fusion degradation (UFD) pathway. Several proteins involved in this pathway have been identified. This family includes UFD1, a 40kD protein that is essential for vegetative cell viability. The human UFD1 gene is expressed at high levels during embryogenesis, especially in the eyes and in the inner ear primordia and is thought to be important in the determination of ectoderm-derived structures, including neural crest cells. In addition, this gene is deleted in the CATCH-22 (cardiac defects, abnormal facies, thymic hypoplasia, cleft palate and hypocalcaemia with deletions on chromosome 22) syndrome. This clinical syndrome is associated with a variety of developmental defects, all characterized by microdeletions on 22q11.2. Two such developmental defects are the DiGeorge syndrome OMIM:188400, and the velo-cardio- facial syndrome OMIM:145410. Several of the abnormalities associated with these conditions are thought to be due to defective neural crest cell differentiation.",".",".",".",".","."]
["ENSRNOG00000065499",1,0.084135269,10,0.643304382,0.130786096,-2.93471892,0.010188395,0.006405802,"down","yes","ENSRNOG00000065499","lncRNA","chr10:105220758-105222728:-",".",".",".",".","gi|755541096|ref|XR_880376.1|",130,{"v":2e-59,"d":"2.00E-59"},"PREDICTED: Mus musculus uncharacterized LOC102640451 (LOC102640451), transcript variant X2, ncRNA",".",".",".",".",".",".",".",".","pfam04820","Trp_halogenase","Tryptophan halogenase. Tryptophan halogenase catalyses the chlorination of tryptophan to form 7-chlorotryptophan. This is the first step in the biosynthesis of pyrrolnitrin, an antibiotic with broad-spectrum anti-fungal activity. Tryptophan halogenase is NADH-dependent.",".",".",".",".","."]
["ENSRNOG00000066292",1,0.084135269,10,0.643304382,0.130786096,-2.93471892,0.010188395,0.006405802,"down","yes","ENSRNOG00000066292","lncRNA","chr19:48159387-48161711:-",".",".",".",".","gi|3068810|gb|AF059580.1|",126,{"v":2e-57,"d":"2.00E-57"},"Murine genomic DNA; partially digested Sau3A fragment, cloned into cosmid vector pEMBLcos2, complete sequence",".",".",".",".",".",".",".",".","pfam00840","Glyco_hydro_7","Glycosyl hydrolase family 7.",".",".",".",".","."]
["ENSRNOG00000067058",1,0.084135269,10,0.643304382,0.130786096,-2.93471892,0.010188395,0.006405802,"down","yes","ENSRNOG00000067058","protein_coding","chr6:91197292-91207959:-","gi|672056378|ref|XP_008762947.1|",627,{"v":2E-70,"d":"2.00E-70"},"PREDICTED: dehydrogenase/reductase SDR family member 7-like isoform X2 [Rattus norvegicus]","gi|672056377|ref|XM_008764725.1|",629,0,"PREDICTED: Rattus norvegicus dehydrogenase/reductase (SDR family) member 7-like (LOC100364391), transcript variant X2, mRNA","Q9Y394",177,{"v":1E-46,"d":"1.00E-46"},"Dehydrogenase/reductase SDR family member 7",".",".",".",".","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.",".",".",".",".","."]
["ENSRNOG00000069941",1,0.084135269,10,0.643304382,0.130786096,-2.93471892,0.010188395,0.006405802,"down","yes","ENSRNOG00000069941","lncRNA","chr19:24245315-24256057:+","gi|148668136|gb|EDL00466.1|",137,2e-07,"mCG1042565, isoform CRA_a, partial [Mus musculus]","gi|83745278|gb|AC156028.2|",243,{"v":3E-122,"d":"3.00E-122"},"Mus musculus BAC clone RP23-61A11 from chromosome 8, complete sequence",".",".",".",".",".",".",".",".","pfam04788","DUF620","Protein of unknown function (DUF620). Family of uncharacterized proteins.",".",".",".",".","."]
["ENSRNOG00000006426",0,0.042067634,8,0.514643505,0.08174131,-3.612790825,0.011887653,0.007365321,"down","yes","Syt1","protein_coding","chr7:43815785-44357803:-","gi|672058640|ref|XP_008763574.1|",1739,0,"PREDICTED: synaptotagmin-1 isoform X1 [Rattus norvegicus]","gi|148356225|ref|NM_001033680.2|",1896,0,"Rattus norvegicus synaptotagmin 1 (Syt1), mRNA","P21707",662,0,"Synaptotagmin-1","SPAPYUK71.03c",60.1,2E-8,"COG5038","pfam00168","C2","C2 domain.","GO:0005513|detection of calcium ion;GO:0007269|neurotransmitter secretion;GO:0007420|brain development;GO:0014059|regulation of dopamine secretion;GO:0016079|synaptic vesicle exocytosis;GO:0016192|vesicle-mediated transport;GO:0017156|calcium ion regulated exocytosis;GO:0017158|regulation of calcium ion-dependent exocytosis;GO:0030154|cell differentiation;GO:0031340|positive regulation of vesicle fusion;GO:0033603|positive regulation of dopamine secretion;GO:0045956|positive regulation of calcium ion-dependent exocytosis;GO:0048278|vesicle docking;GO:0048488|synaptic vesicle endocytosis;GO:0048791|calcium ion-regulated exocytosis of neurotransmitter;GO:0050806|positive regulation of synaptic transmission;GO:0051291|protein heterooligomerization;GO:0051592|response to calcium ion;GO:0051966|regulation of synaptic transmission, glutamatergic;GO:0061669|spontaneous neurotransmitter secretion;GO:0071277|cellular response to calcium ion;GO:0071911|synchronous neurotransmitter secretion;GO:0098746|fast, calcium ion-dependent exocytosis of neurotransmitter;GO:0099502|calcium-dependent activation of synaptic vesicle fusion;GO:1903235|positive regulation of calcium ion-dependent exocytosis of neurotransmitter;GO:1903305|regulation of regulated secretory pathway;GO:1903861|positive regulation of dendrite extension;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0008021|synaptic vesicle;GO:0030141|secretory granule;GO:0030285|integral component of synaptic vesicle membrane;GO:0030424|axon;GO:0030672|synaptic vesicle membrane;GO:0031045|dense core granule;GO:0042584|chromaffin granule membrane;GO:0042734|presynaptic membrane;GO:0043005|neuron projection;GO:0043195|terminal bouton;GO:0043229|intracellular organelle;GO:0044306|neuron projection terminus;GO:0060076|excitatory synapse;GO:0070382|exocytic vesicle;GO:0098686|hippocampal mossy fiber to CA3 synapse;GO:0098978|glutamatergic synapse;","GO:0000149|SNARE binding;GO:0001786|phosphatidylserine binding;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0005516|calmodulin binding;GO:0005543|phospholipid binding;GO:0005544|calcium-dependent phospholipid binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0008022|protein C-terminus binding;GO:0017075|syntaxin-1 binding;GO:0019905|syntaxin binding;GO:0030276|clathrin binding;GO:0030348|syntaxin-3 binding;GO:0042802|identical protein binding;GO:0046982|protein heterodimerization activity;GO:0048306|calcium-dependent protein binding;GO:0050750|low-density lipoprotein particle receptor binding;GO:0061891|calcium ion sensor activity;","K15290","SYT1; synaptotagmin-1"]
["ENSRNOG00000013768",0,0.042067634,8,0.514643505,0.08174131,-3.612790825,0.011887653,0.007365321,"down","yes","Defb1","protein_coding","chr16:70298863-70313604:-","gi|13929150|ref|NP_113998.1|",360,{"v":8e-42,"d":"8.00E-42"},"beta-defensin 1 precursor [Rattus norvegicus]","gi|13929149|ref|NM_031810.1|",392,0,"Rattus norvegicus defensin beta 1 (Defb1), mRNA","O89117",143,{"v":3E-43,"d":"3.00E-43"},"Beta-defensin 1",".",".",".",".","pfam00711","Defensin_beta","Beta defensin. The beta defensins are antimicrobial peptides implicated in the resistance of epithelial surfaces to microbial colonisation.","GO:0002227|innate immune response in mucosa;GO:0002526|acute inflammatory response;GO:0009617|response to bacterium;GO:0019731|antibacterial humoral response;GO:0019933|cAMP-mediated signaling;GO:0031640|killing of cells of other organism;GO:0033574|response to testosterone;GO:0035584|calcium-mediated signaling using intracellular calcium source;GO:0042742|defense response to bacterium;GO:0045087|innate immune response;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:0060474|positive regulation of flagellated sperm motility involved in capacitation;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;","GO:0005615|extracellular space;GO:0019898|extrinsic component of membrane;GO:0097225|sperm midpiece;GO:1990742|microvesicle;","GO:0003674|molecular_function;GO:0003690|double-stranded DNA binding;GO:0031731|CCR6 chemokine receptor binding;GO:0042802|identical protein binding;","K23125","DEFB1; beta-defensin 1"]
["ENSRNOG00000014573",0,0.042067634,8,0.514643505,0.08174131,-3.612790825,0.011887653,0.007365321,"down","yes","Ckmt1","protein_coding","chr3:108330705-108335758:+","gi|826307947|ref|XP_012504792.1|",2010,0,"PREDICTED: creatine kinase U-type, mitochondrial isoform X1 [Propithecus coquereli]","gi|672046796|ref|XM_006234830.2|",1231,0,"PREDICTED: Rattus norvegicus creatine kinase, mitochondrial 1B (Ckmt1b), transcript variant X1, mRNA","P30275",743,0,"Creatine kinase U-type, mitochondrial","SA0482",96.3,{"v":1e-20,"d":"1.00E-20"},"COG3869","pfam00217","ATP-gua_Ptrans","ATP:guanido phosphotransferase, C-terminal catalytic domain. The substrate binding site is located in the cleft between N and C-terminal domains, but most of the catalytic residues are found in the larger C-terminal domain.","GO:0001822|kidney development;GO:0007420|brain development;GO:0007519|skeletal muscle tissue development;GO:0016310|phosphorylation;GO:0021549|cerebellum development;GO:0032091|negative regulation of protein binding;GO:0043066|negative regulation of apoptotic process;GO:0046314|phosphocreatine biosynthetic process;GO:0048565|digestive tract development;","GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0043204|perikaryon;GO:0044289|contact site;","GO:0004111|creatine kinase activity;GO:0005524|ATP binding;GO:0016301|kinase activity;GO:0042802|identical protein binding;","K00933","E2.7.3.2; creatine kinase [EC:2.7.3.2]"]
["ENSRNOG00000017412",0,0.042067634,8,0.514643505,0.08174131,-3.612790825,0.011887653,0.007365321,"down","yes","AABR07001512.1","protein_coding","chr1:48369044-48369595:-","gi|94400930|ref|NP_001035361.1|",581,{"v":6e-74,"d":"6.00E-74"},"deoxyuridine 5'-triphosphate nucleotidohydrolase isoform 2 [Rattus norvegicus]","gi|346227228|ref|NG_027937.2|",346,{"v":5e-180,"d":"5.00E-180"},"Rattus norvegicus deoxyuridine triphosphatase pseudogene (Dut-ps) on chromosome 1","P70583",229,{"v":3e-75,"d":"3.00E-75"},"Deoxyuridine 5'-triphosphate nucleotidohydrolase","SPAC644.05c",132,{"v":8e-39,"d":"8.00E-39"},"COG0756","pfam00692","dUTPase","dUTPase. dUTPase hydrolyses dUTP to dUMP and pyrophosphate.",".",".",".",".","."]
["ENSRNOG00000018905",0,0.042067634,8,0.514643505,0.08174131,-3.612790825,0.011887653,0.007365321,"down","yes","Odad2","protein_coding","chr17:55218991-55409399:-","gi|564391921|ref|XP_006254201.1|",5328,0,"PREDICTED: armadillo repeat-containing protein 4 isoform X2 [Rattus norvegicus]","gi|672082251|ref|XM_006254139.2|",3555,0,"PREDICTED: Rattus norvegicus armadillo repeat containing 4 (Armc4), transcript variant X3, mRNA","B2RY50",1880,0,"Armadillo repeat-containing protein 4",".",".",".",".","pfam13646","HEAT_2","HEAT repeats. This family includes multiple HEAT repeats.","GO:0003341|cilium movement;GO:0003356|regulation of cilium beat frequency;GO:0007368|determination of left/right symmetry;GO:0007507|heart development;GO:0008150|biological_process;GO:0021591|ventricular system development;GO:0036158|outer dynein arm assembly;","GO:0005575|cellular_component;GO:0005930|axoneme;GO:0097546|ciliary base;","GO:0003674|molecular_function;","K24125","ARMC4; armadillo repeat-containing protein 4"]
["ENSRNOG00000026420",0,0.042067634,8,0.514643505,0.08174131,-3.612790825,0.011887653,0.007365321,"down","yes","Iqcg","protein_coding","chr11:67730247-67771168:+","gi|564377110|ref|XP_006248517.1|",1790,0,"PREDICTED: IQ domain-containing protein G isoform X1 [Rattus norvegicus]","gi|62079186|ref|NM_001014230.1|",1614,0,"Rattus norvegicus IQ motif containing G (Iqcg), mRNA","Q5PQQ6",691,0,"Dynein regulatory complex protein 9",".",".",".",".","pfam04111","APG6","Autophagy protein Apg6. In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway.","GO:0007286|spermatid development;GO:0007288|sperm axoneme assembly;GO:0044782|cilium organization;","GO:0002177|manchette;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0031514|motile cilium;GO:0036126|sperm flagellum;","GO:0005516|calmodulin binding;GO:0030544|Hsp70 protein binding;","K24841","IQCG, DRC9; dynein regulatory complex subunit 9"]
["ENSRNOG00000027801",0,0.042067634,8,0.514643505,0.08174131,-3.612790825,0.011887653,0.007365321,"down","yes","Zpbp","protein_coding","chr14:85833548-86033095:-","gi|564384926|ref|XP_006251567.1|",1820,0,"PREDICTED: zona pellucida-binding protein 1 isoform X1 [Rattus norvegicus]","gi|672076903|ref|XM_006251505.2|",1438,0,"PREDICTED: Rattus norvegicus zona pellucida binding protein (Zpbp), transcript variant X1, mRNA","Q62522",629,0,"Zona pellucida-binding protein 1",".",".",".",".","pfam07354","Sp38","Zona-pellucida-binding protein (Sp38). This family contains a number of zona-pellucida-binding proteins that seem to be restricted to mammals. These are sperm proteins that bind to the 90-kDa family of zona pellucida glycoproteins in a calcium-dependent manner. These represent some of the specific molecules that mediate the first steps of gamete interaction, allowing fertilisation to occur.","GO:0001675|acrosome assembly;GO:0007339|binding of sperm to zona pellucida;","GO:0001669|acrosomal vesicle;GO:0002199|zona pellucida receptor complex;GO:0005576|extracellular region;GO:0016021|integral component of membrane;GO:0044297|cell body;",".",".","."]
["ENSRNOG00000032871",0,0.042067634,8,0.514643505,0.08174131,-3.612790825,0.011887653,0.007365321,"down","yes","Mlc1","protein_coding","chr7:120046705-120067049:-","gi|157823887|ref|NP_001101575.1|",1886,0,"membrane protein MLC1 [Rattus norvegicus]","gi|157823886|ref|NM_001108105.1|",1736,0,"Rattus norvegicus megalencephalic leukoencephalopathy with subcortical cysts 1 (Mlc1), mRNA","Q8VHK5",667,0,"Membrane protein MLC1",".",".",".",".","pfam15282","BMP2K_C","BMP-2-inducible protein kinase C-terminus. This family represents the C-terminus of BMP2K and related proteins.","GO:0015031|protein transport;GO:0016192|vesicle-mediated transport;GO:0032388|positive regulation of intracellular transport;GO:0047484|regulation of response to osmotic stress;GO:0071397|cellular response to cholesterol;GO:0072584|caveolin-mediated endocytosis;","GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0005768|endosome;GO:0005769|early endosome;GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005901|caveola;GO:0005911|cell-cell junction;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0031410|cytoplasmic vesicle;GO:0045121|membrane raft;GO:0048471|perinuclear region of cytoplasm;GO:0055037|recycling endosome;GO:0097450|astrocyte end-foot;","GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;","K20070","MLC1; membrane protein MLC1"]
["ENSRNOG00000038165",0,0.042067634,8,0.514643505,0.08174131,-3.612790825,0.011887653,0.007365321,"down","yes","Pjvk","protein_coding","chr3:61596641-61605045:+","gi|564301884|ref|XP_006224560.1|",1804,0,"PREDICTED: pejvakin isoform X1 [Rattus norvegicus]","gi|672016995|ref|XM_006224498.2|",1104,0,"PREDICTED: Rattus norvegicus deafness, autosomal recessive 59 (Dfnb59), transcript variant X1, mRNA","Q0ZLH2",693,0,"Pejvakin",".",".",".",".","pfam04598","Gasdermin","Gasdermin family. The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein","GO:0000302|response to reactive oxygen species;GO:0000425|pexophagy;GO:0007605|sensory perception of sound;GO:0008219|cell death;GO:0050910|detection of mechanical stimulus involved in sensory perception of sound;GO:0097468|programmed cell death in response to reactive oxygen species;GO:0120045|stereocilium maintenance;GO:1900063|regulation of peroxisome organization;","GO:0005737|cytoplasm;GO:0005778|peroxisomal membrane;GO:0030864|cortical actin cytoskeleton;GO:0035253|ciliary rootlet;GO:0043025|neuronal cell body;GO:0120044|stereocilium base;",".","K22147","PJVK, DFNB59; pejvakin"]
["ENSRNOG00000052723",0,0.042067634,8,0.514643505,0.08174131,-3.612790825,0.011887653,0.007365321,"down","yes","AABR07031154.1","snoRNA","chr18:1704945-1705053:-",".",".",".",".","gi|908662265|tpe|LN871987.1|",63,{"v":2e-23,"d":"2.00E-23"},"TPA: Mus musculus SNORA17 (ACA17) gene for small nucleolar RNA SNORA17 (ACA17)",".",".",".",".",".",".",".",".","pfam06317","Arena_RNA_pol","Arenavirus RNA polymerase. This family consists of several Arenavirus RNA polymerase proteins (EC:2.7.7.48).",".",".",".",".","."]
["ENSRNOG00000066616",0,0.042067634,8,0.514643505,0.08174131,-3.612790825,0.011887653,0.007365321,"down","yes","ENSRNOG00000066616","protein_coding","chr3:149220737-149228279:+","gi|672047882|ref|XP_008760660.1|",2713,0,"PREDICTED: MLV-related proviral Env polyprotein-like isoform X2, partial [Rattus norvegicus]","gi|33342289|gb|AC105631.4|",2155,0,"Rattus norvegicus 1 BAC CH230-132J4 (Children's Hospital Oakland Research Institute) complete sequence","P03355",754,0,"Gag-Pol polyprotein","SPAC167.08",81.3,{"v":3e-14,"d":"3.00E-14"},"COG2801","pfam00429","TLV_coat","ENV polyprotein (coat polyprotein).",".",".",".",".","."]
["ENSRNOG00000066826",0,0.042067634,8,0.514643505,0.08174131,-3.612790825,0.011887653,0.007365321,"down","yes","ENSRNOG00000066826","protein_coding","chr2:45405314-45405970:-","gi|114052555|ref|NP_001040560.1|",375,{"v":9e-43,"d":"9.00E-43"},"nucleolar protein 16 [Rattus norvegicus]","gi|675644374|ref|XM_002744520.3|",155,{"v":7e-74,"d":"7.00E-74"},"PREDICTED: Callithrix jacchus NOP16 nucleolar protein (NOP16), mRNA","Q1RP77",149,{"v":3e-44,"d":"3.00E-44"},"Nucleolar protein 16",".",".",".",".","pfam09420","Nop16","Ribosome biogenesis protein Nop16. Nop16 is a protein involved in ribosome biogenesis.",".",".",".",".","."]
["ENSRNOG00000067429",0,0.042067634,8,0.514643505,0.08174131,-3.612790825,0.011887653,0.007365321,"down","yes","ENSRNOG00000067429","lncRNA","chr18:26106691-26108255:+","gi|537191568|gb|ERE77141.1|",153,2e-09,"E3 ubiquitin-protein ligase [Cricetulus griseus]","gi|21844648|gb|AC115305.4|",728,0,"Mus musculus BAC clone RP24-372L1 from 18, complete sequence",".",".",".",".",".",".",".",".","pfam15153","CYTL1","Cytokine-like protein 1. The function of this family of proteins, CYTL1, has not, as yet, been determined. However it is thought to be a secretory protein expressed in CD34+ haemopoietic cells. This family of proteins is found in eukaryotes. Proteins in this family are typically between 134 and 145 amino acids in length. There are two conserved sequence motifs: PPTCYSR and DDC.",".",".",".",".","."]
["ENSRNOG00000067632",0,0.042067634,8,0.514643505,0.08174131,-3.612790825,0.011887653,0.007365321,"down","yes","ENSRNOG00000067632","processed_pseudogene","chr14:35936429-35936668:+","gi|594030515|ref|XP_006040172.1|",408,{"v":7e-50,"d":"7.00E-50"},"PREDICTED: 40S ribosomal protein S2-like [Bubalus bubalis]","gi|309951072|ref|NG_027835.1|",237,{"v":1E-119,"d":"1.00E-119"},"Rattus norvegicus ribosomal protein S2, pseudogene 6 (Rps2-ps6) on chromosome 9","P27952",166,{"v":1E-50,"d":"1.00E-50"},"40S ribosomal protein S2","SPCC576.08c",78.6,{"v":3e-18,"d":"3.00E-18"},"COG0098","pfam03719","Ribosomal_S5_C","Ribosomal protein S5, C-terminal domain.",".",".",".",".","."]
["ENSRNOG00000068846",0,0.042067634,8,0.514643505,0.08174131,-3.612790825,0.011887653,0.007365321,"down","yes","ENSRNOG00000068846","lncRNA","chr7:110968014-110981134:+",".",".",".",".","gi|354788923|gb|JN953424.1|",568,0,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Csnk1e:tm1a(KOMP)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam15374","CCDC71L","Coiled-coil domain-containing protein 71L. The protein family, Coiled-coil domain-containing protein 71L, is a domain of unknown function, which is found in eukaryotes.",".",".",".",".","."]
["ENSRNOG00000068928",0,0.042067634,8,0.514643505,0.08174131,-3.612790825,0.011887653,0.007365321,"down","yes","ENSRNOG00000068928","lncRNA","chr10:65396554-65398879:-","gi|148698044|gb|EDL29991.1|",146,8e-08,"chloride intracellular channel 4 (mitochondrial), isoform CRA_c, partial [Mus musculus]","gi|354799448|gb|JN963949.1|",865,0,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Zfp207:tm1a(EUCOMM)Hmgu; transgenic",".",".",".",".",".",".",".",".","pfam03053","Corona_NS3b","ORF3b coronavirus protein. Members of this family are non-structural proteins, approximately 250 amino acid residues long. They are found in transmissible gastroenteritis coronavirus (TGEV) and porcine respiratory coronavirus (PRCV) isolates. These proteins are found on the same mRNA as another product, designated ORF3a. While ORF3a/b has been implicated in TGEV and PRCV pathogenesis, its precise role remains unclear.",".",".",".",".","."]
["ENSRNOG00000070101",0,0.042067634,8,0.514643505,0.08174131,-3.612790825,0.011887653,0.007365321,"down","yes","ENSRNOG00000070101","lncRNA","chr1:230353307-230354400:+",".",".",".",".","gi|56790448|gb|AC102159.10|",493,0,"Mus musculus chromosome 19, clone RP23-398L11, complete sequence",".",".",".",".",".",".",".",".","pfam12455","Dynactin","Dynein associated protein. This domain family is found in eukaryotes, and is approximately 280 amino acids in length. The family is found in association with pfam01302. There is a single completely conserved residue E that may be functionally important. Dynactin has been associated with Dynein, a kinesin protein which is involved in organelle transport, mitotic spindle assembly and chromosome segregation. Dynactin anchors Dynein to specific subcellular structures.",".",".",".",".","."]
["ENSRNOG00000002771",5,0.420676343,20,1.286608764,0.32696524,-1.612790825,0.012040669,0.007452494,"down","yes","Ereg","protein_coding","chr14:17027287-17041062:-","gi|11078689|ref|NP_067721.1|",781,{"v":7e-102,"d":"7.00E-102"},"proepiregulin preproprotein [Rattus norvegicus]","gi|11078688|ref|NM_021689.1|",828,0,"Rattus norvegicus epiregulin (Ereg), mRNA","Q9Z0L5",305,{"v":2e-103,"d":"2.00E-103"},"Proepiregulin",".",".",".",".","pfam00008","EGF","EGF-like domain. There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.","GO:0001525|angiogenesis;GO:0001550|ovarian cumulus expansion;GO:0001556|oocyte maturation;GO:0001819|positive regulation of cytokine production;GO:0007143|female meiotic nuclear division;GO:0007173|epidermal growth factor receptor signaling pathway;GO:0007267|cell-cell signaling;GO:0008283|cell proliferation;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0009299|mRNA transcription;GO:0019221|cytokine-mediated signaling pathway;GO:0030728|ovulation;GO:0032755|positive regulation of interleukin-6 production;GO:0042327|positive regulation of phosphorylation;GO:0042700|luteinizing hormone signaling pathway;GO:0043434|response to peptide hormone;GO:0043616|keratinocyte proliferation;GO:0045089|positive regulation of innate immune response;GO:0045740|positive regulation of DNA replication;GO:0045741|positive regulation of epidermal growth factor-activated receptor activity;GO:0045766|positive regulation of angiogenesis;GO:0045840|positive regulation of mitotic nuclear division;GO:0045860|positive regulation of protein kinase activity;GO:0045892|negative regulation of transcription, DNA-templated;GO:0048146|positive regulation of fibroblast proliferation;GO:0048160|primary follicle stage;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0051151|negative regulation of smooth muscle cell differentiation;GO:0051781|positive regulation of cell division;","GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0005154|epidermal growth factor receptor binding;GO:0008083|growth factor activity;","K09784","EREG; epiregulin"]
["ENSRNOG00000005883",5,0.420676343,20,1.286608764,0.32696524,-1.612790825,0.012040669,0.007452494,"down","yes","Nek10","protein_coding","chr15:10381140-10559722:-","gi|564385550|ref|XP_006251783.1|",4909,0,"PREDICTED: serine/threonine-protein kinase Nek10 isoform X1 [Rattus norvegicus]","gi|672077763|ref|XM_006251721.2|",5971,0,"PREDICTED: Rattus norvegicus NIMA-related kinase 10 (Nek10), transcript variant X3, mRNA","Q3UGM2",1768,0,"Serine/threonine-protein kinase Nek10",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006468|protein phosphorylation;GO:0031954|positive regulation of protein autophosphorylation;GO:0043406|positive regulation of MAP kinase activity;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:1902749|regulation of cell cycle G2/M phase transition;","GO:0005576|extracellular region;GO:1902911|protein kinase complex;","GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;","K20879","NEK10; NIMA (never in mitosis gene a)-related kinase 10 [EC:2.7.11.1]"]
["ENSRNOG00000010657",14,1.177893761,38,2.444556651,0.481843512,-1.053363417,0.012750205,0.007852381,"down","yes","ENSRNOG00000010657","protein_coding","chr8:80719012-80721104:+","gi|295391701|ref|NP_001171296.1|",865,{"v":1e-115,"d":"1.00E-115"},"uncharacterized protein LOC100363289 [Rattus norvegicus]","gi|295391700|ref|NM_001177825.1|",494,0,"Rattus norvegicus LRRGT00022-like (LOC100363289), mRNA",".",".",".",".",".",".",".",".","pfam02932","Neur_chan_memb","Neurotransmitter-gated ion-channel transmembrane region. This family includes the four transmembrane helices that form the ion channel.",".",".",".",".","."]
["ENSRNOG00000052128",14,1.177893761,38,2.444556651,0.481843512,-1.053363417,0.012750205,0.007852381,"down","yes","Clec2e","protein_coding","chr4:162534278-162541971:-","gi|672051253|ref|XP_008761558.1|",1052,{"v":4e-132,"d":"4.00E-132"},"PREDICTED: C-type lectin domain family 2 member E isoform X1 [Rattus norvegicus]","gi|672051252|ref|XM_008763336.1|",1653,0,"PREDICTED: Rattus norvegicus C-type lectin domain family 2, member E (Clec2e), transcript variant X1, mRNA","Q80XD9",304,{"v":2e-94,"d":"2.00E-94"},"C-type lectin domain family 2 member E",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type",".","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0030246|carbohydrate binding;GO:0046703|natural killer cell lectin-like receptor binding;","K10072","CLEC2D; C-type lectin domain family 2 member D"]
["ENSRNOG00000015903",6,0.504811612,22,1.41526964,0.356689353,-1.487259943,0.013067103,0.008034824,"down","yes","Add2","protein_coding","chr4:118497416-118538505:+","gi|6978449|ref|NP_036623.1|",3051,0,"beta-adducin isoform b [Rattus norvegicus]","gi|158081760|ref|NM_012491.2|",3251,0,"Rattus norvegicus adducin 2 (Add2), transcript variant 2, mRNA","Q9QYB8",1123,0,"Beta-adducin","CC1201",144,{"v":1e-36,"d":"1.00E-36"},"COG0235","pfam00596","Aldolase_II","Class II Aldolase and Adducin N-terminal domain. This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.","GO:0006811|ion transport;GO:0007416|synapse assembly;GO:0030097|hemopoiesis;GO:0032092|positive regulation of protein binding;GO:0050900|leukocyte migration;GO:0050901|leukocyte tethering or rolling;GO:0051016|barbed-end actin filament capping;GO:0051017|actin filament bundle assembly;GO:0065003|protein-containing complex assembly;","GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0008290|F-actin capping protein complex;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0031410|cytoplasmic vesicle;GO:0044853|plasma membrane raft;GO:0098794|postsynapse;GO:0098978|glutamatergic synapse;","GO:0003779|actin binding;GO:0005200|structural constituent of cytoskeleton;GO:0005516|calmodulin binding;GO:0019901|protein kinase binding;GO:0030507|spectrin binding;GO:0042803|protein homodimerization activity;GO:0046982|protein heterodimerization activity;GO:0051015|actin filament binding;","K18622","ADD; adducin"]
["ENSRNOG00000031951",3,0.252405806,15,0.964956573,0.261572192,-1.93471892,0.013622473,0.008341461,"down","yes","ENSRNOG00000031951","protein_coding","chr3:44581068-44630051:+","gi|295391840|ref|NP_001171287.1|",3053,0,"uncharacterized protein LOC100361645 [Rattus norvegicus]","gi|295391839|ref|NM_001177816.1|",1755,0,"Rattus norvegicus LRRGT00075-like (LOC100361645), mRNA","P11369",185,{"v":6e-48,"d":"6.00E-48"},"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam12488","DUF3704","Protein of unknown function (DUF3704). This domain family is found in eukaryotes, and is approximately 30 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000065005",3,0.252405806,15,0.964956573,0.261572192,-1.93471892,0.013622473,0.008341461,"down","yes","ENSRNOG00000065005","lncRNA","chr1:213194874-213195879:-",".",".",".",".","gi|354790064|gb|JN954565.1|",235,{"v":7e-118,"d":"7.00E-118"},"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Psat1:tm1e(KOMP)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam10324","7TM_GPCR_Srw","Serpentine type 7TM GPCR chemoreceptor Srw. Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srw is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srw do not appear to be under as strong an adaptive evolutionary pressure as those of Srz.",".",".",".",".","."]
["ENSRNOG00000063400",7,0.588946881,24,1.543930516,0.381459447,-1.390398404,0.013720922,0.008397966,"down","yes","Shisa9","protein_coding","chr10:3337979-3627773:-","gi|589942480|ref|XP_006983953.1|",1949,0,"PREDICTED: protein shisa-9 isoform X1 [Peromyscus maniculatus bairdii]","gi|672066485|ref|XM_008767465.1|",1854,0,"PREDICTED: Rattus norvegicus shisa family member 9 (Shisa9), transcript variant X3, mRNA","Q9CZN4",753,0,"Protein shisa-9",".",".",".",".","pfam13908","Shisa","Wnt and FGF inhibitory regulator. Shisa is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface.",".",".",".",".","."]
["ENSRNOG00000014904",8,0.673082149,26,1.672591393,0.402418757,-1.313230543,0.014073968,0.008596663,"down","yes","Ppp1r3e","protein_coding","chr15:28347854-28349603:-","gi|281332139|ref|NP_001163046.1|",888,{"v":2e-112,"d":"2.00E-112"},"protein phosphatase 1 regulatory subunit 3E [Rattus norvegicus]","gi|268835744|ref|NM_001167908.1|",1215,0,"Mus musculus protein phosphatase 1, regulatory (inhibitor) subunit 3E (Ppp1r3e), mRNA","P0C7L8",344,{"v":5e-113,"d":"5.00E-113"},"Protein phosphatase 1 regulatory subunit 3E",".",".",".",".","pfam03370","CBM_21","Putative phosphatase regulatory subunit. This family consists of several eukaryotic proteins that are thought to be involved in the regulation of glycogen metabolizm. For instance, the mouse PTG protein has been shown to interact with glycogen synthase, phosphorylase kinase, phosphorylase a: these three enzymes have key roles in the regulation of glycogen metabolizm. PTG also binds the catalytic subunit of protein phosphatase 1 (PP1C) and localizes it to glycogen. Subsets of similar interactions have been observed with several other members of this family, such as the yeast PIG1, PIG2, GAC1 and GIP2 proteins. While the precise function of these proteins is not known, they may serve a scaffold function, bringing together the key enzymes in glycogen metabolizm. This family is a carbohydrate binding domain.","GO:0005977|glycogen metabolic process;GO:0005979|regulation of glycogen biosynthetic process;GO:0005981|regulation of glycogen catabolic process;GO:0006470|protein dephosphorylation;GO:0045725|positive regulation of glycogen biosynthetic process;","GO:0000164|protein phosphatase type 1 complex;GO:0042587|glycogen granule;","GO:0004721|phosphoprotein phosphatase activity;GO:0008157|protein phosphatase 1 binding;GO:0050196|[phosphorylase] phosphatase activity;GO:2001069|glycogen binding;","K07189","PPP1R3; protein phosphatase 1 regulatory subunit 3A/B/C/D/E"]
["ENSRNOG00000067241",10,0.841352686,30,1.929913146,0.435953653,-1.197753326,0.014120305,0.008618192,"down","yes","ENSRNOG00000067241","pseudogene","chr15:31572849-31688313:+","gi|564386398|ref|XP_006252128.1|",4143,0,"PREDICTED: intraflagellar transport protein 88 homolog isoform X1 [Rattus norvegicus]","gi|672078283|ref|XR_596131.1|",3913,0,"PREDICTED: Rattus norvegicus intraflagellar transport 88 (Ift88), transcript variant X3, misc_RNA","Q61371",1594,0,"Intraflagellar transport protein 88 homolog","BB0195",71.2,{"v":2e-11,"d":"2.00E-11"},"COG0457","pfam06083","IL17","Interleukin-17. IL-17 is a potent proinflammatory cytokine produced by activated memory T cells. The IL-17 family is thought to represent a distinct signaling system that appears to have been highly conserved across vertebrate evolution.",".",".",".",".","."]
["ENSRNOG00000019779",9,0.757217418,28,1.801252269,0.42038388,-1.250220746,0.014189418,0.008654553,"down","yes","Disc1","protein_coding","chr19:53014616-53219778:+","gi|108935976|sp|Q810H6.2|DISC1_RAT",4290,0,"RecName: Full=Disrupted in schizophrenia 1 homolog","gi|672085247|ref|XM_008772616.1|",2380,0,"PREDICTED: Rattus norvegicus disrupted in schizophrenia 1 (Disc1), transcript variant X1, mRNA","Q810H6",1654,0,"Disrupted in schizophrenia 1 homolog",".",".",".",".","pfam12795","MscS_porin","Mechanosensitive ion channel porin domain. The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are heptamers of three transmembrane subunits with seven converging M3 domains, and this MscS_porin is towards the N-terminal of the molecules. The high concentration of negative charges at the extracellular entrance of the pore helps select the cations for efflux.","GO:0000226|microtubule cytoskeleton organization;GO:0001764|neuron migration;GO:0001954|positive regulation of cell-matrix adhesion;GO:0002052|positive regulation of neuroblast proliferation;GO:0007399|nervous system development;GO:0008104|protein localization;GO:0010975|regulation of neuron projection development;GO:0010976|positive regulation of neuron projection development;GO:0021799|cerebral cortex radially oriented cell migration;GO:0021846|cell proliferation in forebrain;GO:0021852|pyramidal neuron migration;GO:0030177|positive regulation of Wnt signaling pathway;GO:0031929|TOR signaling;GO:0032091|negative regulation of protein binding;GO:0034613|cellular protein localization;GO:0045773|positive regulation of axon extension;GO:0051560|mitochondrial calcium ion homeostasis;GO:0051602|response to electrical stimulus;GO:0051966|regulation of synaptic transmission, glutamatergic;GO:0060070|canonical Wnt signaling pathway;GO:0060271|cilium assembly;GO:0060998|regulation of dendritic spine development;GO:0071539|protein localization to centrosome;GO:0090128|regulation of synapse maturation;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:1905515|non-motile cilium assembly;GO:2000060|positive regulation of ubiquitin-dependent protein catabolic process;","GO:0005634|nucleus;GO:0005739|mitochondrion;GO:0005783|endoplasmic reticulum;GO:0005813|centrosome;GO:0005829|cytosol;GO:0005871|kinesin complex;GO:0005874|microtubule;GO:0008021|synaptic vesicle;GO:0014069|postsynaptic density;GO:0030286|dynein complex;GO:0030424|axon;GO:0036064|ciliary basal body;GO:0044297|cell body;GO:0045111|intermediate filament cytoskeleton;GO:0048471|perinuclear region of cytoplasm;GO:0090724|central region of growth cone;GO:0097546|ciliary base;","GO:0005515|protein binding;GO:0008092|cytoskeletal protein binding;GO:0019894|kinesin binding;GO:0044877|protein-containing complex binding;GO:0060090|molecular adaptor activity;","K16534","DISC1; disrupted in schizophrenia 1 protein"]
["ENSRNOG00000042333",9,0.757217418,28,1.801252269,0.42038388,-1.250220746,0.014189418,0.008654553,"down","yes","Dnal1","protein_coding","chr6:103747753-103778878:+","gi|564356686|ref|XP_006240414.1|",1169,{"v":2e-143,"d":"2.00E-143"},"PREDICTED: dynein light chain 1, axonemal isoform X1 [Rattus norvegicus]","gi|298891063|emb|FQ211665.1|",2772,0,"Rattus norvegicus TL0AAA84YB13 mRNA sequence","A0A096MJZ0",365,{"v":7E-114,"d":"7.00E-114"},"Dynein light chain 1, axonemal","SPAC4A8.12c",65.9,{"v":4e-10,"d":"4.00E-10"},"COG4886","pfam12799","LRR_4","Leucine Rich repeats (2 copies). Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.","GO:0036158|outer dynein arm assembly;","GO:0005737|cytoplasm;GO:0005874|microtubule;GO:0030286|dynein complex;GO:0042995|cell projection;","GO:0043014|alpha-tubulin binding;GO:0045504|dynein heavy chain binding;","K10411","DNAL1; dynein axonemal light chain 1"]
["ENSRNOG00000003972",4,0.336541075,17,1.093617449,0.307731991,-1.700253667,0.016224999,0.009799514,"down","yes","Tshr","protein_coding","chr6:110341581-110474538:+","gi|149025304|gb|EDL81671.1|",3878,0,"rCG20940 [Rattus norvegicus]","gi|6981679|ref|NM_012888.1|",4431,0,"Rattus norvegicus thyroid stimulating hormone receptor (Tshr), mRNA","P21463",1487,0,"Thyrotropin receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007166|cell surface receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007190|activation of adenylate cyclase activity;GO:0008284|positive regulation of cell proliferation;GO:0008344|adult locomotory behavior;GO:0009755|hormone-mediated signaling pathway;GO:0030183|B cell differentiation;GO:0038194|thyroid-stimulating hormone signaling pathway;GO:0040012|regulation of locomotion;GO:0040018|positive regulation of multicellular organism growth;GO:0060122|inner ear receptor cell stereocilium organization;GO:0071542|dopaminergic neuron differentiation;GO:0090103|cochlea morphogenesis;GO:0120162|positive regulation of cold-induced thermogenesis;GO:1904588|cellular response to glycoprotein;GO:1905229|cellular response to thyrotropin-releasing hormone;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0043235|receptor complex;GO:0045121|membrane raft;","GO:0004996|thyroid-stimulating hormone receptor activity;GO:0008528|G protein-coupled peptide receptor activity;GO:0038023|signaling receptor activity;GO:0044877|protein-containing complex binding;","K04249","TSHR; thyrotropin receptor"]
["ENSRNOG00000014477",4,0.336541075,17,1.093617449,0.307731991,-1.700253667,0.016224999,0.009799514,"down","yes","Acvr2b","protein_coding","chr8:119138812-119170458:+","gi|564366242|ref|XP_006244134.1|",2581,0,"PREDICTED: activin receptor type-2B isoform X1 [Rattus norvegicus]","gi|672063574|ref|XM_006244072.2|",1901,0,"PREDICTED: Rattus norvegicus activin A receptor, type IIB (Acvr2b), transcript variant X1, mRNA","P27040",994,0,"Activin receptor type-2B",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001501|skeletal system development;GO:0001702|gastrulation with mouth forming second;GO:0001822|kidney development;GO:0001946|lymphangiogenesis;GO:0001974|blood vessel remodeling;GO:0006355|regulation of transcription, DNA-templated;GO:0006468|protein phosphorylation;GO:0007165|signal transduction;GO:0007368|determination of left/right symmetry;GO:0007389|pattern specification process;GO:0007498|mesoderm development;GO:0007507|heart development;GO:0009749|response to glucose;GO:0009791|post-embryonic development;GO:0009952|anterior/posterior pattern specification;GO:0009966|regulation of signal transduction;GO:0019953|sexual reproduction;GO:0030073|insulin secretion;GO:0030324|lung development;GO:0030325|adrenal gland development;GO:0030501|positive regulation of bone mineralization;GO:0030509|BMP signaling pathway;GO:0031016|pancreas development;GO:0032147|activation of protein kinase activity;GO:0032924|activin receptor signaling pathway;GO:0032927|positive regulation of activin receptor signaling pathway;GO:0035265|organ growth;GO:0042475|odontogenesis of dentin-containing tooth;GO:0045669|positive regulation of osteoblast differentiation;GO:0048617|embryonic foregut morphogenesis;GO:0048705|skeletal system morphogenesis;GO:0060021|roof of mouth development;GO:0060836|lymphatic endothelial cell differentiation;GO:0060840|artery development;GO:0060841|venous blood vessel development;GO:0061298|retina vasculature development in camera-type eye;GO:0071363|cellular response to growth factor stimulus;GO:0120163|negative regulation of cold-induced thermogenesis;GO:1901389|negative regulation of transforming growth factor beta activation;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0032991|protein-containing complex;GO:0043235|receptor complex;GO:0048179|activin receptor complex;","GO:0004674|protein serine/threonine kinase activity;GO:0004675|transmembrane receptor protein serine/threonine kinase activity;GO:0004712|protein serine/threonine/tyrosine kinase activity;GO:0005524|ATP binding;GO:0017002|activin-activated receptor activity;GO:0019838|growth factor binding;GO:0034711|inhibin binding;GO:0046872|metal ion binding;GO:0048185|activin binding;","K13596","ACVR2B; activin receptor type-2B [EC:2.7.11.30]"]
["ENSRNOG00000055683",4,0.336541075,17,1.093617449,0.307731991,-1.700253667,0.016224999,0.009799514,"down","yes","AC098125.3","processed_pseudogene","chr1:210225539-210226594:+","gi|157819651|ref|NP_001100073.1|",1738,0,"T-complex protein 1 subunit eta [Rattus norvegicus]","gi|302370961|ref|NG_023531.1|",1056,0,"Rattus norvegicus chaperonin containing Tcp1, subunit 7 (eta), pseudogene 1 (Cct7-ps1) on chromosome 1","P80313",667,0,"T-complex protein 1 subunit eta","SPBC25H2.12c",470,{"v":9e-162,"d":"9.00E-162"},"COG0459","pfam00118","Cpn60_TCP1","TCP-1/cpn60 chaperonin family. This family includes members from the HSP60 chaperone family and the TCP-1 (T-complex protein) family.",".",".",".",".","."]
["ENSRNOG00000066119",4,0.336541075,17,1.093617449,0.307731991,-1.700253667,0.016224999,0.009799514,"down","yes","ENSRNOG00000066119","lncRNA","chr6:87704196-87710487:-",".",".",".",".","gi|672056281|ref|XM_008764701.1|",500,0,"PREDICTED: Rattus norvegicus polymerase (DNA directed), epsilon 2, accessory subunit (Pole2), transcript variant X7, mRNA",".",".",".",".",".",".",".",".","pfam04749","PLAC8","PLAC8 family. This family includes the Placenta-specific gene 8 protein.",".",".",".",".","."]
["ENSRNOG00000067308",4,0.336541075,17,1.093617449,0.307731991,-1.700253667,0.016224999,0.009799514,"down","yes","ENSRNOG00000067308","protein_coding","chr1:67553726-67555499:-","gi|564296772|ref|XP_006223098.1|",400,{"v":1e-47,"d":"1.00E-47"},"PREDICTED: zinc finger protein 582-like isoform X1 [Rattus norvegicus]","gi|672013065|ref|XM_006223036.2|",227,{"v":5e-114,"d":"5.00E-114"},"PREDICTED: Rattus norvegicus zinc finger protein 582-like (LOC102548162), transcript variant X1, mRNA","Q96NG8",114,{"v":2e-29,"d":"2.00E-29"},"Zinc finger protein 582",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000069130",4,0.336541075,17,1.093617449,0.307731991,-1.700253667,0.016224999,0.009799514,"down","yes","ENSRNOG00000069130","protein_coding","chr2:23585644-23607712:+","gi|45478192|gb|AAS66267.1|",1819,0,"LRRGT00176 [Rattus norvegicus]","gi|50838842|gb|AC099449.6|",2399,0,"Rattus norvegicus 1 BAC CH230-57B2 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P11260",496,{"v":3E-160,"d":"3.00E-160"},"LINE-1 retrotransposable element ORF1 protein","SPCC1223.08c_2",103,{"v":4e-23,"d":"4.00E-23"},"COG0262","pfam02994","Transposase_22","L1 transposable element.",".",".",".",".","."]
["ENSRNOG00000012827",2,0.168270537,12,0.771965258,0.217976827,-2.197753326,0.016623813,0.010003769,"down","yes","Mlf1","protein_coding","chr2:151648511-151681652:+","gi|157818443|ref|NP_001101150.1|",1501,0,"myeloid leukemia factor 1 [Rattus norvegicus]","gi|298906173|emb|FQ216411.1|",1132,0,"Rattus norvegicus TL0ACA43YB13 mRNA sequence","Q9QWV4",515,0,"Myeloid leukemia factor 1",".",".",".",".","pfam10248","Mlf1IP","Myelodysplasia-myeloid leukemia factor 1-interacting protein. This entry is the conserved central region of a group of proteins that are putative transcriptional repressors. The structure contains a putative 14-3-3 binding motif involved in the subcellular localisation of various regulatory molecules, and it may be that interaction with the transcription factor DREF could be regulated through this motif. DREF regulates proliferation-related genes in Drosophila. Mlf1IP is expressed in both the nuclei and the cytoplasm and thus may have multi-functions.","GO:0002318|myeloid progenitor cell differentiation;GO:0006351|transcription, DNA-templated;GO:0006355|regulation of transcription, DNA-templated;GO:0008150|biological_process;GO:0051726|regulation of cell cycle;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005929|cilium;GO:0031514|motile cilium;GO:0036064|ciliary basal body;GO:0097546|ciliary base;GO:0097730|non-motile cilium;","GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0019904|protein domain specific binding;","K15622","MLF1; myeloid leukemia factor 1"]
["ENSRNOG00000016483",2,0.168270537,12,0.771965258,0.217976827,-2.197753326,0.016623813,0.010003769,"down","yes","Myo16","protein_coding","chr16:78884406-79248388:-","gi|672080674|ref|XP_008769606.1|",9059,0,"PREDICTED: unconventional myosin-XVI isoform X1 [Rattus norvegicus]","gi|672080673|ref|XM_008771384.1|",6836,0,"PREDICTED: Rattus norvegicus myosin XVI (Myo16), transcript variant X1, mRNA","Q9ERC1",3476,0,"Unconventional myosin-XVI","YAL029c",321,{"v":3e-88,"d":"3.00E-88"},"COG5022","pfam00063","Myosin_head","Myosin head (motor domain).","GO:0008285|negative regulation of cell proliferation;GO:0014065|phosphatidylinositol 3-kinase signaling;GO:0021549|cerebellum development;GO:0048812|neuron projection morphogenesis;GO:2000134|negative regulation of G1/S transition of mitotic cell cycle;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016459|myosin complex;GO:0048471|perinuclear region of cytoplasm;","GO:0003774|motor activity;GO:0003779|actin binding;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0019903|protein phosphatase binding;GO:0044877|protein-containing complex binding;GO:0051015|actin filament binding;","K17481","MYO16; myosin XVI"]
["ENSRNOG00000019464",2,0.168270537,12,0.771965258,0.217976827,-2.197753326,0.016623813,0.010003769,"down","yes","Ttc9c","protein_coding","chr1:205701768-205712773:-","gi|56090471|ref|NP_001007694.1|",876,{"v":3e-107,"d":"3.00E-107"},"tetratricopeptide repeat protein 9C [Rattus norvegicus]","gi|298890948|emb|FQ211550.1|",3120,0,"Rattus norvegicus TL0AAA88YL09 mRNA sequence",".",".",".",".",".",".",".",".","pfam13414","TPR_11","TPR repeat.",".",".",".","K24930","TTC9; tetratricopeptide repeat protein 9"]
["ENSRNOG00000020066",2,0.168270537,12,0.771965258,0.217976827,-2.197753326,0.016623813,0.010003769,"down","yes","Pcdhb11","protein_coding","chr18:29126669-29129062:+","gi|109506480|ref|XP_001055576.1|",3818,0,"PREDICTED: protocadherin-3 [Rattus norvegicus]","gi|564320525|ref|XM_001064927.4|",2394,0,"PREDICTED: Rattus norvegicus protocadherin beta 11 (Pcdhb11), mRNA","Q63418",1223,0,"Protocadherin-3",".",".",".",".","pfam08266","Cadherin_2","Cadherin-like. This cadherin domain is usually the most N-terminal copy of the domain.","GO:0007155|cell adhesion;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005887|integral component of plasma membrane;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;","K16494","PCDHB; protocadherin beta"]
["ENSRNOG00000028826",2,0.168270537,12,0.771965258,0.217976827,-2.197753326,0.016623813,0.010003769,"down","yes","AC128901.1","protein_coding","chr4:148270351-148271151:-","gi|4506661|ref|NP_000963.1|",1087,{"v":7e-147,"d":"7.00E-147"},"60S ribosomal protein L7a [Homo sapiens]","gi|298904426|emb|FQ221876.1|",762,0,"Rattus norvegicus TL0ADA30YK04 mRNA sequence","P62425",423,{"v":2e-148,"d":"2.00E-148"},"60S ribosomal protein L7a","YLL045c",268,{"v":3e-88,"d":"3.00E-88"},"COG1358","pfam01248","Ribosomal_L7Ae","Ribosomal protein L7Ae/L30e/S12e/Gadd45 family. This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118.",".",".",".",".","."]
["ENSRNOG00000010158",14,1.177893761,37,2.380226213,0.494866309,-1.014889269,0.017137074,0.010281954,"down","yes","Magel2","protein_coding","chr1:115880474-115884250:+","gi|392344312|ref|XP_001054803.2|",4326,0,"PREDICTED: MAGE-like protein 2 [Rattus norvegicus]","gi|672013777|ref|XM_002725637.4|",3777,0,"PREDICTED: Rattus norvegicus MAGE-like 2 (Magel2), mRNA","Q9QZ04",1477,0,"MAGE-like protein 2",".",".",".",".","pfam01454","MAGE","MAGE family. The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumors but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0034314|Arp2/3 complex-mediated actin nucleation;GO:0042147|retrograde transport, endosome to Golgi;GO:0042752|regulation of circadian rhythm;GO:0045892|negative regulation of transcription, DNA-templated;GO:0051127|positive regulation of actin nucleation;GO:0070534|protein K63-linked ubiquitination;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005829|cytosol;GO:0030904|retromer complex;","GO:0004842|ubiquitin-protein transferase activity;","K23950","MAGEL2; MAGE-like protein 2"]
["ENSRNOG00000067837",14,1.177893761,37,2.380226213,0.494866309,-1.014889269,0.017137074,0.010281954,"down","yes","ENSRNOG00000067837","lncRNA","chr16:69165481-69217498:+","gi|149036607|gb|EDL91225.1|",177,{"v":4e-12,"d":"4.00E-12"},"rCG56442 [Rattus norvegicus]","gi|32996900|gb|AC115361.5|",317,{"v":4e-163,"d":"4.00E-163"},"Mus musculus BAC clone RP24-76P12 from chromosome 8, complete sequence",".",".",".",".",".",".",".",".","pfam01603","B56","Protein phosphatase 2A regulatory B subunit (B56 family). Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolizm. The ability of this widely distributed heterotrimeric enzyme to act on a diverse array of substrates is largely controlled by the nature of its regulatory B subunit. There are multiple families of B subunits (See also pfam01240), this family is called the B56 family.",".",".",".",".","."]
["ENSRNOG00000017198",1,0.084135269,9,0.578973944,0.145317884,-2.782715827,0.017646434,0.010545727,"down","yes","Hif3a","protein_coding","chr1:77722471-77749758:-","gi|11968112|ref|NP_071973.1|",3144,0,"hypoxia-inducible factor 3-alpha [Rattus norvegicus]","gi|402745390|ref|NM_022528.2|",2014,0,"Rattus norvegicus hypoxia inducible factor 3, alpha subunit (Hif3a), mRNA","Q9JHS2",1218,0,"Hypoxia-inducible factor 3-alpha",".",".",".",".","pfam14598","PAS_11","PAS domain. This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).","GO:0001525|angiogenesis;GO:0001666|response to hypoxia;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006366|transcription by RNA polymerase II;GO:0006915|apoptotic process;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0071456|cellular response to hypoxia;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016607|nuclear speck;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0005515|protein binding;GO:0046983|protein dimerization activity;","K09096","HIF3A; hypoxia-inducible factor 3 alpha"]
["ENSRNOG00000050312",1,0.084135269,9,0.578973944,0.145317884,-2.782715827,0.017646434,0.010545727,"down","yes","Ism2","protein_coding","chr6:106926175-106944514:-","gi|672056956|ref|XP_008763117.1|",1830,0,"PREDICTED: LOW QUALITY PROTEIN: isthmin-2 isoform X2 [Rattus norvegicus]","gi|568981064|ref|XM_006516433.1|",1575,0,"PREDICTED: Mus musculus isthmin 2 homolog (zebrafish) (Ism2), transcript variant X1, mRNA","Q6H9L7",458,{"v":1e-148,"d":"1.00E-148"},"Isthmin-2",".",".",".",".","pfam03782","AMOP","AMOP domain. This domain may have a role in cell adhesion. It is called the AMOP domain after Adhesion associated domain in MUC4 and Other Proteins. This domain is extracellular and contains a number of cysteines that probably form disulphide bridges.",".",".",".","K24435","ISM; isthmin"]
["ENSRNOG00000051585",1,0.084135269,9,0.578973944,0.145317884,-2.782715827,0.017646434,0.010545727,"down","yes","Gm23245","snoRNA","chr12:26880788-26880922:-","gi|795353125|ref|XP_011931948.1|",123,9e-07,"PREDICTED: LOW QUALITY PROTEIN: T-complex protein 1 subunit zeta-like [Cercocebus atys]","gi|5295932|dbj|AB022159.1|",120,{"v":6e-55,"d":"6.00E-55"},"Mus musculus Cctz-1 gene for chaperonin containing TCP-1 zeta-1 subunit, complete cds",".",".",".",".",".",".",".",".","pfam02903","Alpha-amylase_N","Alpha amylase, N-terminal ig-like domain.",".",".",".",".","."]
["ENSRNOG00000051714",1,0.084135269,9,0.578973944,0.145317884,-2.782715827,0.017646434,0.010545727,"down","yes","SNORA70","snoRNA","chr4:165144932-165145065:-","gi|859922493|ref|XP_012902851.1|",111,6e-06,"PREDICTED: 60S ribosomal protein L10-like [Mustela putorius furo]","gi|908663336|tpe|LN872540.1|",119,{"v":2e-54,"d":"2.00E-54"},"TPA: Mus musculus SNORA70 (U70) gene for small nucleolar RNA SNORA70 (U70)",".",".",".",".",".",".",".",".","pfam06267","DUF1028","Family of unknown function (DUF1028). Family of bacterial and archaeal proteins with unknown function. Some members are associated with a C-terminal peptidoglycan binding domain. So perhaps this could be an enzyme involved in peptidoglycan metabolizm.",".",".",".",".","."]
["ENSRNOG00000056350",1,0.084135269,9,0.578973944,0.145317884,-2.782715827,0.017646434,0.010545727,"down","yes","Gm24644","scaRNA","chr3:90428366-90428504:+",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","pfam12449","DUF3684","Protein of unknown function (DUF3684). This domain family is found in eukaryotes, and is typically between 1072 and 1090 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000062517",1,0.084135269,9,0.578973944,0.145317884,-2.782715827,0.017646434,0.010545727,"down","yes","RGD1565653","protein_coding","chr8:110989940-110995640:+","gi|507631328|ref|XP_004627903.1|",564,{"v":1e-69,"d":"1.00E-69"},"PREDICTED: transcription elongation factor B polypeptide 2 [Octodon degus]","gi|298910142|emb|FQ222166.1|",377,0,"Rattus norvegicus TL0ADA27YL19 mRNA sequence","P62870",219,{"v":2E-70,"d":"2.00E-70"},"Elongin-B",".",".",".",".","pfam00240","ubiquitin","Ubiquitin family. This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) Nedd8, Elongin B, Rub1, and Parkin. A number of them are thought to carry a distinctive five-residue motif termed the proteasome-interacting motif (PIM), which may have a biologically significant role in protein delivery to proteasomes and recruitment of proteasomes to transcription sites.",".",".",".",".","."]
["ENSRNOG00000066049",1,0.084135269,9,0.578973944,0.145317884,-2.782715827,0.017646434,0.010545727,"down","yes","ENSRNOG00000066049","lncRNA","chr7:107854715-107856810:+","gi|149066135|gb|EDM16008.1|",154,{"v":5e-10,"d":"5.00E-10"},"rCG60114, isoform CRA_a [Rattus norvegicus]","gi|672059653|ref|XR_593605.1|",978,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102548374 (LOC102548374), transcript variant X7, ncRNA",".",".",".",".",".",".",".",".","pfam15005","IZUMO","Izumo sperm-egg fusion. Izumo is a molecule with a single immunoglobulin (Ig) domain. It is thought that Izumo bind to putative Izumo receptors on the oocyte. Izumo is not detectable on the surface of fresh sperm but becomes exposed only after an exocytotic process, the acrosome reaction, has occurred. Studies have shown that knock-out mice (Izumo-/- males) were sterile despite normal mating behaviour and ejaculation, indicating the importance of the protein in fertilization. There are cysteine residues thought to form a disulphide bridge. Izumo is a typical type I membrane glycoprotein with one immunoglobulin-like domain and a putative N-glycoside link motif (Asn 204). There is a conserved GCL sequence motif. Izumo expression has been found to be testis-specific. This family of proteins is found in eukaryotes and are typically between 193 and 305 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000068353",1,0.084135269,9,0.578973944,0.145317884,-2.782715827,0.017646434,0.010545727,"down","yes","ENSRNOG00000068353","protein_coding","chr1:258030937-258037823:+","gi|975107385|ref|XP_015269135.1|",539,{"v":1e-68,"d":"1.00E-68"},"PREDICTED: transcription elongation factor SPT4 isoform X1 [Gekko japonicus]","gi|298894371|emb|FQ224188.1|",261,{"v":7e-133,"d":"7.00E-133"},"Rattus norvegicus TL0ACA74YF17 mRNA sequence","Q4R941",209,{"v":5e-69,"d":"5.00E-69"},"Transcription elongation factor SPT4","ECU08g1660",85.1,{"v":6e-21,"d":"6.00E-21"},"COG5204","pfam06093","Spt4","Spt4/RpoE2 zinc finger. This family consists of several eukaryotic transcription elongation Spt4 proteins as well as archaebacterial RpoE2. Three transcription-elongation factors Spt4, Spt5, and Spt6 are conserved among eukaryotes and are essential for transcription via the modulation of chromatin structure. Spt4 and Spt5 are tightly associated in a complex, while the physical association of the Spt4-Spt5 complex with Spt6 is considerably weaker. It has been demonstrated that Spt4, Spt5, and Spt6 play roles in transcription elongation in both yeast and humans including a role in activation by Tat. It is known that Spt4, Spt5, and Spt6 are general transcription-elongation factors, controlling transcription both positively and negatively in important regulatory and developmental roles. RpoE2 is one of 13 subunits in the archaeal RNA polymerase. These proteins contain a C4-type zinc finger, and the structure has been solved in. The structure reveals that Spt4-Spt5 binding is governed by an acid-dipole interaction between Spt5 and Spt4, and the complex binds to and travels along the elongating RNA polymerase. The Spt4-Spt5 complex is likely to be an ancient, core component of the transcription elongation machinery.",".",".",".",".","."]
["ENSRNOG00000070307",1,0.084135269,9,0.578973944,0.145317884,-2.782715827,0.017646434,0.010545727,"down","yes","ENSRNOG00000070307","lncRNA","chr6:88958917-88960555:+",".",".",".",".","gi|354797392|gb|JN961893.1|",384,0,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Tmx1:tm1a(EUCOMM)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam13761","DUF4166","Domain of unknown function (DUF4166). This domain is often found at the C-terminus of proteins containing pfam03435.",".",".",".",".","."]
["ENSRNOG00000063146",13,1.093758492,35,2.251565336,0.485776928,-1.041634124,0.017859092,0.01066462,"down","yes","Rab39a","protein_coding","chr8:54088129-54106483:-","gi|157822741|ref|NP_001101618.1|",1160,{"v":1e-152,"d":"1.00E-152"},"ras-related protein Rab-39A [Rattus norvegicus]","gi|133891651|ref|NM_175562.3|",1019,0,"Mus musculus RAB39, member RAS oncogene family (Rab39), mRNA","Q8BHD0",439,{"v":1e-149,"d":"1.00E-149"},"Ras-related protein Rab-39A",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.",".",".",".",".","."]
["ENSRNOG00000066441",13,1.093758492,35,2.251565336,0.485776928,-1.041634124,0.017859092,0.01066462,"down","yes","ENSRNOG00000066441","lncRNA","chr7:90851993-90867875:-","gi|829747857|ref|XP_012613529.1|",434,{"v":5e-98,"d":"5.00E-98"},"PREDICTED: zinc finger protein 572 isoform X2 [Microcebus murinus]","gi|672021890|ref|XR_347996.2|",1808,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102550763 (LOC102550763), transcript variant X4, ncRNA","Q32KN0",169,{"v":2E-92,"d":"2.00E-92"},"Zinc finger protein 572",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.",".",".",".",".","."]
["ENSRNOG00000066520",13,1.093758492,35,2.251565336,0.485776928,-1.041634124,0.017859092,0.01066462,"down","yes","ENSRNOG00000066520","protein_coding","chr9:20660322-20662313:-","gi|672023860|ref|XP_008756222.1|",225,{"v":8e-22,"d":"8.00E-22"},"PREDICTED: polyubiquitin 8-like isoform X1 [Rattus norvegicus]","gi|672064669|ref|XM_008766948.1|",123,{"v":2e-56,"d":"2.00E-56"},"PREDICTED: Rattus norvegicus polyubiquitin 12-like (LOC102557398), transcript variant X2, partial mRNA",".",".",".",".",".",".",".",".","pfam02141","DENN","DENN (AEX-3) domain. DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.",".",".",".",".","."]
["ENSRNOG00000001183",5,0.420676343,19,1.222278326,0.344173937,-1.538790244,0.018019673,0.010753436,"down","yes","Hnf1a","protein_coding","chr12:41645587-41672104:+","gi|6981638|ref|NP_036801.1|",2871,0,"hepatocyte nuclear factor 1-alpha [Rattus norvegicus]","gi|6981637|ref|NM_012669.1|",3538,0,"Rattus norvegicus HNF1 homeobox A (Hnf1a), mRNA","P15257",1112,0,"Hepatocyte nuclear factor 1-alpha",".",".",".",".","pfam04812","HNF-1B_C","Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus. This family consists of a region found within the alpha isoform and at the C terminus of the beta isoform of the homeobox-containing transcription factor of HNF-1. Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative splicing. The C-terminal region of HNF-1 is responsible for the activation of transcription. Mutations and polymorphisms in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001824|blastocyst development;GO:0001889|liver development;GO:0001890|placenta development;GO:0006338|chromatin remodeling;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006366|transcription by RNA polymerase II;GO:0006633|fatty acid biosynthetic process;GO:0006699|bile acid biosynthetic process;GO:0006783|heme biosynthetic process;GO:0006979|response to oxidative stress;GO:0008104|protein localization;GO:0008203|cholesterol metabolic process;GO:0009749|response to glucose;GO:0015721|bile acid and bile salt transport;GO:0015908|fatty acid transport;GO:0016573|histone acetylation;GO:0030073|insulin secretion;GO:0030111|regulation of Wnt signaling pathway;GO:0030326|embryonic limb morphogenesis;GO:0031018|endocrine pancreas development;GO:0035623|renal glucose absorption;GO:0042593|glucose homeostasis;GO:0043691|reverse cholesterol transport;GO:0045453|bone resorption;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046323|glucose import;GO:0046883|regulation of hormone secretion;GO:0048341|paraxial mesoderm formation;GO:0048608|reproductive structure development;GO:0060261|positive regulation of transcription initiation from RNA polymerase II promoter;GO:0060395|SMAD protein signal transduction;","GO:0000785|chromatin;GO:0001750|photoreceptor outer segment;GO:0005634|nucleus;GO:0005667|transcription factor complex;GO:0005737|cytoplasm;GO:0032991|protein-containing complex;GO:0045120|pronucleus;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001221|transcription cofactor binding;GO:0001223|transcription coactivator binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003690|double-stranded DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0043565|sequence-specific DNA binding;GO:0046982|protein heterodimerization activity;GO:0046983|protein dimerization activity;","K08036","TCF1, HNF1A; transcription factor 1, hepatocyte nuclear factor 1-alpha"]
["ENSRNOG00000009773",5,0.420676343,19,1.222278326,0.344173937,-1.538790244,0.018019673,0.010753436,"down","yes","Elovl4","protein_coding","chr8:84702362-84729697:-","gi|300796614|ref|NP_001178725.1|",1649,0,"elongation of very long chain fatty acids protein 4 [Rattus norvegicus]","gi|880899996|ref|XM_005073689.2|",949,0,"PREDICTED: Mesocricetus auratus ELOVL fatty acid elongase 4 (Elovl4), mRNA","Q9EQC4",620,0,"Elongation of very long chain fatty acids protein 4",".",".",".",".","pfam01151","ELO","GNS1/SUR4 family. Members of this family are involved in long chain fatty acid elongation systems that produce the 26-carbon precursors for ceramide and sphingolipid synthesis. Predicted to be integral membrane proteins, in eukaryotes they are probably located on the endoplasmic reticulum. Yeast ELO3 affects plasma membrane H+-ATPase activity, and may act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1.","GO:0006636|unsaturated fatty acid biosynthetic process;GO:0008150|biological_process;GO:0019367|fatty acid elongation, saturated fatty acid;GO:0030148|sphingolipid biosynthetic process;GO:0034625|fatty acid elongation, monounsaturated fatty acid;GO:0034626|fatty acid elongation, polyunsaturated fatty acid;GO:0035338|long-chain fatty-acyl-CoA biosynthetic process;GO:0042761|very long-chain fatty acid biosynthetic process;","GO:0005575|cellular_component;GO:0005783|endoplasmic reticulum;GO:0030176|integral component of endoplasmic reticulum membrane;","GO:0003674|molecular_function;GO:0009922|fatty acid elongase activity;GO:0102336|3-oxo-arachidoyl-CoA synthase activity;GO:0102337|3-oxo-cerotoyl-CoA synthase activity;GO:0102338|3-oxo-lignoceronyl-CoA synthase activity;GO:0102756|very-long-chain 3-ketoacyl-CoA synthase activity;","K10249","ELOVL4; elongation of very long chain fatty acids protein 4 [EC:2.3.1.199]"]
["ENSRNOG00000060401",5,0.420676343,19,1.222278326,0.344173937,-1.538790244,0.018019673,0.010753436,"down","yes","Dusp13","protein_coding","chr15:2533547-2575539:+","gi|672077367|ref|XP_008768696.1|",1385,{"v":3E-176,"d":"3.00E-176"},"PREDICTED: dual specificity protein phosphatase 13 isoform B isoform X1 [Rattus norvegicus]","gi|672077368|ref|XM_003751425.3|",1067,0,"PREDICTED: Rattus norvegicus dual specificity protein phosphatase 13-like (LOC100909469), transcript variant X2, mRNA","Q9QYJ7",400,{"v":3e-128,"d":"3.00E-128"},"Dual specificity protein phosphatase 13 isoform B","SPBC17A3.06",58.5,5e-08,"COG2453","pfam00782","DSPc","Dual specificity phosphatase, catalytic domain. Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a \"recognition\" region.","GO:0016311|dephosphorylation;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0043409|negative regulation of MAPK cascade;","GO:0005737|cytoplasm;GO:0016021|integral component of membrane;","GO:0004725|protein tyrosine phosphatase activity;GO:0008138|protein tyrosine/serine/threonine phosphatase activity;GO:0016791|phosphatase activity;GO:0033549|MAP kinase phosphatase activity;","K14165","K14165; atypical dual specificity phosphatase [EC:3.1.3.16 3.1.3.48]"]
["ENSRNOG00000063177",12,1.009623224,33,2.12290446,0.475585804,-1.072222444,0.018528656,0.011024552,"down","yes","ENSRNOG00000063177","lncRNA","chr19:22369252-22370454:+","gi|149026742|gb|EDL82735.1|",239,{"v":6e-22,"d":"6.00E-22"},"rCG51697 [Rattus norvegicus]","gi|672084642|ref|XR_361784.2|",636,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102550991 (LOC102550991), ncRNA",".",".",".",".",".",".",".",".","pfam12292","DUF3624","Protein of unknown function (DUF3624). This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length. There is a conserved GRC sequence motif.",".",".",".",".","."]
["ENSRNOG00000068552",12,1.009623224,33,2.12290446,0.475585804,-1.072222444,0.018528656,0.011024552,"down","yes","ENSRNOG00000068552","lncRNA","chr4:105288091-105294156:-",".",".",".",".","gi|672018450|ref|XR_600719.1|",849,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103692155 (LOC103692155), ncRNA",".",".",".",".",".",".",".",".","pfam01941","AdoMet_Synthase","S-adenosylmethionine synthetase (AdoMet synthetase). This family consists of several archaebacterial S-adenosylmethionine synthetase C(AdoMet synthetase or MAT) (EC 2.5.1.6). S-Adenosylmethionine (AdoMet) occupies a central role in the metabolizm of all cells. The biological roles of AdoMet include acting as the primary methyl group donor, as a precursor to the polyamines, and as a progenitor of a 5'-deoxyadenosyl radical. S-Adenosylmethionine synthetase catalyses the only known route of AdoMet biosynthesis. The synthetic process occurs in a unique reaction in which the complete triphosphate chain is displaced from ATP and a sulfonium ion formed. MATs from various organisms contain ~400-amino acid polypeptide chains.",".",".",".",".","."]
["ENSRNOG00000036680",11,0.925487955,31,1.994243584,0.464079696,-1.107555517,0.019117769,0.011320556,"down","yes","Notum","protein_coding","chr10:105933249-105940315:-","gi|564375622|ref|XP_006247949.1|",2334,0,"PREDICTED: protein notum homolog isoform X1 [Rattus norvegicus]","gi|195927012|ref|NM_001013975.2|",2041,0,"Rattus norvegicus notum pectinacetylesterase homolog (Drosophila) (Notum), mRNA","Q8R116",888,0,"Palmitoleoyl-protein carboxylesterase NOTUM",".",".",".",".","pfam03283","PAE","Pectinacetylesterase.","GO:0030178|negative regulation of Wnt signaling pathway;GO:0030500|regulation of bone mineralization;GO:0060348|bone development;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:1990697|protein depalmitoleylation;",".","GO:0016298|lipase activity;GO:1990699|palmitoleyl hydrolase activity;","K19882","NOTUM; O-palmitoleoyl-L-serine hydrolase [EC:3.1.1.98]"]
["ENSRNOG00000049880",11,0.925487955,31,1.994243584,0.464079696,-1.107555517,0.019117769,0.011320556,"down","yes","Tmem200c","protein_coding","chr9:108805787-108812226:+","gi|353703760|ref|NP_001238855.1|",1822,0,"transmembrane protein 200C [Rattus norvegicus]","gi|353703759|ref|NM_001251926.1|",3064,0,"Rattus norvegicus transmembrane protein 200C (Tmem200c), mRNA","A6NKL6",390,{"v":3e-119,"d":"3.00E-119"},"Transmembrane protein 200C",".",".",".",".","pfam10177","DUF2371","Uncharacterized conserved protein (DUF2371). This is a family of proteins conserved from nematodes to humans. The function is not known.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000059010",11,0.925487955,31,1.994243584,0.464079696,-1.107555517,0.019117769,0.011320556,"down","yes","Rnf212","protein_coding","chr14:949448-987831:+","gi|149028689|gb|EDL84030.1|",490,{"v":7e-54,"d":"7.00E-54"},"rCG57241, isoform CRA_a [Rattus norvegicus]","gi|298889109|emb|FQ223894.1|",2556,0,"Rattus norvegicus TL0ACA83YK13 mRNA sequence","F6TQD1",177,{"v":1e-47,"d":"1.00E-47"},"Probable E3 SUMO-protein ligase RNF212",".",".",".",".","pfam04987","PigN","Phosphatidylinositolglycan class N (PIG-N). Phosphatidylinositolglycan class N (PIG-N) is a mammalian homologue of the yeast protein MCD4P and is expressed in the endoplasmic reticulum. PIG-N is essential for glycosylphosphatidylinositol anchor synthesis. Glycosylphosphatidylinositol (GPI)-anchored proteins are cell surface-localized proteins that serve many important cellular functions.","GO:0006311|meiotic gene conversion;GO:0007131|reciprocal meiotic recombination;GO:0051026|chiasma assembly;","GO:0000795|synaptonemal complex;","GO:0046872|metal ion binding;","K25662","RNF212; E3 SUMO-protein ligase RNF212 [EC:2.3.2.-]"]
["ENSRNOG00000067832",11,0.925487955,31,1.994243584,0.464079696,-1.107555517,0.019117769,0.011320556,"down","yes","ENSRNOG00000067832","protein_coding","chr3:145431037-145454326:-","gi|62078575|ref|NP_001013945.1|",1583,0,"protein NDRG3 [Rattus norvegicus]","gi|62078574|ref|NM_001013923.1|",2340,0,"Rattus norvegicus NDRG family member 3 (Ndrg3), mRNA","Q6AYR2",614,0,"Protein NDRG3",".",".",".",".","pfam03096","Ndr","Ndr family. This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, and Ndr3. Their similarity was previously noted. The precise molecular and cellular function of members of this family is still unknown. Yet, they are known to be involved in cellular differentiation events. The Ndr1 group was the first to be discovered. Their expression is repressed by the proto-oncogenes N-myc and c-myc, and in line with this observation, Ndr1 protein expression is down-regulated in neoplastic cells, and is reactivated when differentiation is induced by chemicals such as retinoic acid. Ndr2 and Ndr3 expression is not under the control of N-myc or c-myc. Ndr1 expression is also activated by several chemicals: tunicamycin and homocysteine induce Ndr1 in human umbilical endothelial cells; nickel induces Ndr1 in several cell types. Members of this family are found in wide variety of multicellular eukaryotes, including an Ndr1 type protein in Helianthus annuus (sunflower), known as Sf21. Interestingly, the highest scoring matches in the noise are all alpha/beta hydrolases pfam00561, suggesting that this family may have an enzymatic function (Bateman A pers. obs.).",".",".",".",".","."]
["ENSRNOG00000061564",6,0.504811612,21,1.350939202,0.37367456,-1.420145747,0.019153366,0.011336065,"down","yes","AABR07031724.1","lncRNA","chr18:26703780-26728467:-",".",".",".",".","gi|29825883|gb|AC131675.4|",217,{"v":5E-108,"d":"5.00E-108"},"Mus musculus BAC clone RP23-328L1 from chromosome 18, complete sequence",".",".",".",".",".",".",".",".","pfam06350","HSL_N","Hormone-sensitive lipase (HSL) N-terminus. This family consists of several mammalian hormone-sensitive lipase (HSL) proteins (EC:3.1.1.-). Hormone-sensitive lipase, a key enzyme in fatty acid mobilisation, overall energy homeostasis, and possibly steroidogenesis, is acutely controlled through reversible phosphorylation by catecholamines and insulin.",".",".",".",".","."]
["ENSRNOG00000061680",6,0.504811612,21,1.350939202,0.37367456,-1.420145747,0.019153366,0.011336065,"down","yes","AABR07066800.1","snoRNA","chr9:14203474-14203604:+",".",".",".",".","gi|298897740|emb|FQ227960.1|",94,{"v":2e-40,"d":"2.00E-40"},"Rattus norvegicus TL0AEA11YB07 mRNA sequence",".",".",".",".",".",".",".",".","pfam08995","NIP_1","Necrosis inducing protein-1. Necrosis inducing protein-1, a fungal avirulence protein produced by plants, consists of two parts containing beta-sheets of two and three anti-parallel strands, respectively. Five intramolecular disulfide bonds, stabilize these parts and their position with respect to each other, providing a high level of stability.",".",".",".",".","."]
["ENSRNOG00000064150",6,0.504811612,21,1.350939202,0.37367456,-1.420145747,0.019153366,0.011336065,"down","yes","ENSRNOG00000064150","lncRNA","chr17:83659433-83682702:+",".",".",".",".","gi|672030333|ref|XR_598232.1|",492,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102550221 (LOC102550221), transcript variant X1, ncRNA",".",".",".",".",".",".",".",".","pfam05875","Ceramidase","Ceramidase. This family consists of several ceramidases. Ceramidases are enzymes involved in regulating cellular levels of ceramides, sphingoid bases, and their phosphates, EC:3.5.1.23.",".",".",".",".","."]
["ENSRNOG00000002487",9,0.757217418,27,1.736921831,0.435953653,-1.197753326,0.01989898,0.011724584,"down","yes","ENSRNOG00000002487","protein_coding","chrX:130648538-130737056:-","gi|157819037|ref|NP_001100419.1|",1610,0,"muscleblind-like protein 3 [Rattus norvegicus]","gi|157819036|ref|NM_001106949.1|",1657,0,"Rattus norvegicus muscleblind-like splicing regulator 3 (Mbnl3), mRNA","Q8R003",592,0,"Muscleblind-like protein 3",".",".",".",".","pfam00642","zf-CCCH","Zinc finger C-x8-C-x5-C-x3-H type (and similar).","GO:0000381|regulation of alternative mRNA splicing, via spliceosome;GO:0043484|regulation of RNA splicing;GO:0045662|negative regulation of myoblast differentiation;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;","GO:0003723|RNA binding;GO:0046872|metal ion binding;","K14943","MBNL; muscleblind"]
["ENSRNOG00000062326",9,0.757217418,27,1.736921831,0.435953653,-1.197753326,0.01989898,0.011724584,"down","yes","ENSRNOG00000062326","protein_coding","chr2:38218547-38224396:-","gi|7328170|emb|CAB82416.1|",140,1e-09,"hypothetical protein [Homo sapiens]","gi|755546525|ref|XR_382746.2|",162,{"v":4E-78,"d":"4.00E-78"},"PREDICTED: Mus musculus importin 11 (Ipo11), transcript variant X4, misc_RNA","Q8K2V6",59.7,{"v":2e-10,"d":"2.00E-10"},"Importin-11",".",".",".",".","pfam03575","Peptidase_S51","Peptidase family S51.",".",".",".",".","."]
["ENSRNOG00000067362",8,0.673082149,25,1.608260955,0.418515507,-1.256647015,0.01998394,0.011770325,"down","yes","ENSRNOG00000067362","lncRNA","chr10:92638661-92640558:+","gi|149054622|gb|EDM06439.1|",275,{"v":4e-26,"d":"4.00E-26"},"rCG32981 [Rattus norvegicus]","gi|755540035|ref|XM_006534506.2|",546,0,"PREDICTED: Mus musculus helicase with zinc finger domain (Helz), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam02135","zf-TAZ","TAZ zinc finger. The TAZ2 domain of CBP binds to other transcription factors such as the p53 tumor suppressor protein, E1A oncoprotein, MyoD, and GATA-1. The zinc coordinating motif that is necessary for binding to target DNA sequences consists of HCCC.",".",".",".",".","."]
["ENSRNOG00000000508",0,0.042067634,7,0.450313067,0.09341864,-3.420145747,0.021270607,0.01242818,"down","yes","Armc12","protein_coding","chr20:6587859-6598352:+","gi|166157536|ref|NP_001107249.1|",1790,0,"armadillo repeat-containing protein 12 [Rattus norvegicus]","gi|166157535|ref|NM_001113777.1|",1213,0,"Rattus norvegicus armadillo repeat containing 12 (Armc12), mRNA",".",".",".",".",".",".",".",".","pfam04826","Arm_2","Armadillo-like. This domain contains armadillo-like repeats. Proteins containing this domain interact with numerous other proteins, through these interactions they are involved in a wide variety of processes including carcinogenesis, control of cellular ageing and survival, regulation of circadian rhythm and lysosomal sorting of G protein-coupled receptors.",".",".",".","K24168","ARMC12; armadillo repeat-containing protein 12"]
["ENSRNOG00000004470",0,0.042067634,7,0.450313067,0.09341864,-3.420145747,0.021270607,0.01242818,"down","yes","Il24","protein_coding","chr13:42353090-42358487:-","gi|18959256|ref|NP_579845.1|",901,{"v":4e-118,"d":"4.00E-118"},"interleukin-24 precursor [Rattus norvegicus]","gi|18959255|ref|NM_133311.1|",1153,0,"Rattus norvegicus interleukin 24 (Il24), mRNA","Q9JI24",351,{"v":1E-119,"d":"1.00E-119"},"Interleukin-24",".",".",".",".","pfam14565","IL22","Interleukin 22 IL-10-related T-cell-derived-inducible factor. Interleukin-22 is distantly related to interleukin (IL)-10, and is produced by activated T cells. IL-22 is a ligand for CRF2-4, a member of the class II cytokine receptor family.","GO:0006915|apoptotic process;GO:0007165|signal transduction;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0030336|negative regulation of cell migration;GO:0042060|wound healing;GO:0042501|serine phosphorylation of STAT protein;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0043065|positive regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043280|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0071222|cellular response to lipopolysaccharide;GO:0071353|cellular response to interleukin-4;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005783|endoplasmic reticulum;","GO:0003674|molecular_function;GO:0005125|cytokine activity;","K22668","IL24; interleukin 24"]
["ENSRNOG00000008539",0,0.042067634,7,0.450313067,0.09341864,-3.420145747,0.021270607,0.01242818,"down","yes","Lgals2","protein_coding","chr7:110403173-110404802:-","gi|19424308|ref|NP_598283.1|",657,{"v":7e-85,"d":"7.00E-85"},"galectin-2 [Rattus norvegicus]","gi|19424307|ref|NM_133599.1|",563,0,"Rattus norvegicus lectin, galactoside-binding, soluble, 2 (Lgals2), mRNA","Q9Z144",257,{"v":2e-86,"d":"2.00E-86"},"Galectin-2",".",".",".",".","pfam00337","Gal-bind_lectin","Galactoside-binding lectin. This family contains galactoside binding lectins.   The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).",".","GO:0005737|cytoplasm;","GO:0016936|galactoside binding;GO:0030246|carbohydrate binding;","K10090","LGALS2; galectin-2"]
["ENSRNOG00000009388",0,0.042067634,7,0.450313067,0.09341864,-3.420145747,0.021270607,0.01242818,"down","yes","Sptssb","lncRNA","chr2:154133733-154163120:-","gi|19526830|ref|NP_598436.1|",403,{"v":1E-42,"d":"1.00E-42"},"serine palmitoyltransferase small subunit B isoform a [Mus musculus]","gi|404351657|ref|NM_001271299.1|",2227,0,"Rattus norvegicus serine palmitoyltransferase, small subunit B (Sptssb), transcript variant 1, mRNA","Q925E8",159,{"v":5e-44,"d":"5.00E-44"},"Serine palmitoyltransferase small subunit B",".",".",".",".","pfam11779","DUF3317","Protein of unknown function (DUF3317). This is a short family of proteins conserved from fungi and plants to human. One each of the human and mouse members is annotated as being androgen down-regulated protein expressed in mouse prostate, with a potential signal transduction function, and all appear to be membrane proteins.","GO:0007029|endoplasmic reticulum organization;GO:0030148|sphingolipid biosynthetic process;GO:0046513|ceramide biosynthetic process;GO:1904220|regulation of serine C-palmitoyltransferase activity;","GO:0016021|integral component of membrane;GO:0017059|serine C-palmitoyltransferase complex;","GO:0004758|serine C-palmitoyltransferase activity;",".","."]
["ENSRNOG00000011671",0,0.042067634,7,0.450313067,0.09341864,-3.420145747,0.021270607,0.01242818,"down","yes","ENSRNOG00000011671","protein_coding","chr19:28669059-28704508:+","gi|71043912|ref|NP_001020935.1|",833,{"v":9e-106,"d":"9.00E-106"},"uncharacterized protein C4orf51 homolog [Rattus norvegicus]","gi|71043911|ref|NM_001025764.1|",1519,0,"Rattus norvegicus LOC498933 (LOC498933), mRNA",".",".",".",".",".",".",".",".","pfam03363","Herpes_LP","Herpesvirus leader protein.",".",".",".",".","."]
["ENSRNOG00000011824",0,0.042067634,7,0.450313067,0.09341864,-3.420145747,0.021270607,0.01242818,"down","yes","Trh","protein_coding","chr4:124742111-124744637:-","gi|7242211|ref|NP_037178.1|",1071,{"v":2e-141,"d":"2.00E-141"},"thyrotropin releasing hormone preproprotein [Rattus norvegicus]","gi|485464617|ref|NM_013046.3|",1391,0,"Rattus norvegicus thyrotropin releasing hormone (Trh), mRNA","P01150",417,{"v":5e-143,"d":"5.00E-143"},"Pro-thyrotropin-releasing hormone",".",".",".",".","pfam05438","TRH","Thyrotropin-releasing hormone (TRH). This family consists of several thyrotropin-releasing hormone (TRH) proteins. Thyrotropin-Releasing Hormone (TRH; pyroGlu-His-Pro-NH2), originally isolated as a hypothalamic neuropeptide hormone, most likely acts also as a neuromodulator and/or neurotransmitter in the central nervous system (CNS). This interpretation is supported by the identification of a peptidase localized on the surface of neuronal cells which has been termed TRH-degrading ectoenzyme (TRH-DE) since it selectively inactivates TRH. TRH has been used clinically for the treatment of spinocerebellar degeneration and disturbance of consciousness in humans.","GO:0001666|response to hypoxia;GO:0001692|histamine metabolic process;GO:0007628|adult walking behavior;GO:0009409|response to cold;GO:0009749|response to glucose;GO:0009755|hormone-mediated signaling pathway;GO:0014050|negative regulation of glutamate secretion;GO:0014054|positive regulation of gamma-aminobutyric acid secretion;GO:0014070|response to organic cyclic compound;GO:0032024|positive regulation of insulin secretion;GO:0042755|eating behavior;GO:0045471|response to ethanol;GO:0051412|response to corticosterone;GO:2000252|negative regulation of feeding behavior;","GO:0005576|extracellular region;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0030141|secretory granule;","GO:0008437|thyrotropin-releasing hormone activity;","K05253","TRH; thyrotropin-releasing hormone"]
["ENSRNOG00000012450",0,0.042067634,7,0.450313067,0.09341864,-3.420145747,0.021270607,0.01242818,"down","yes","Dynlrb2","protein_coding","chr19:44520134-44531387:+","gi|25072207|ref|NP_083573.1|",428,{"v":4e-48,"d":"4.00E-48"},"dynein light chain roadblock-type 2 [Mus musculus]","gi|62945691|gb|AC112969.12|",655,0,"Mus musculus chromosome 8, clone RP24-331K7, complete sequence","Q9DAJ5",169,{"v":1e-49,"d":"1.00E-49"},"Dynein light chain roadblock-type 2",".",".",".",".","pfam03259","Robl_LC7","Roadblock/LC7 domain. This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.","GO:0007018|microtubule-based movement;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0005868|cytoplasmic dynein complex;GO:0005874|microtubule;","GO:0003674|molecular_function;GO:0045505|dynein intermediate chain binding;","K10419","DYNLRB, DNCL2; dynein light chain roadblock-type"]
["ENSRNOG00000014816",0,0.042067634,7,0.450313067,0.09341864,-3.420145747,0.021270607,0.01242818,"down","yes","Slc1a1","protein_coding","chr1:226549842-226630402:+","gi|148747368|ref|NP_037164.3|",2470,0,"excitatory amino acid transporter 3 [Rattus norvegicus]","gi|1072115|gb|U39555.1|RNU39555",2251,0,"Rattus norvegicus high affinity glutamate transporter EAAC1 mRNA, complete cds","P51907",956,0,"Excitatory amino acid transporter 3","aq_1330",189,{"v":3E-52,"d":"3.00E-52"},"COG1301","pfam00375","SDF","Sodium:dicarboxylate symporter family.","GO:0001662|behavioral fear response;GO:0001932|regulation of protein phosphorylation;GO:0001975|response to amphetamine;GO:0002027|regulation of heart rate;GO:0006749|glutathione metabolic process;GO:0006750|glutathione biosynthetic process;GO:0006801|superoxide metabolic process;GO:0006882|cellular zinc ion homeostasis;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007212|dopamine receptor signaling pathway;GO:0007215|glutamate receptor signaling pathway;GO:0007420|brain development;GO:0007611|learning or memory;GO:0007613|memory;GO:0007625|grooming behavior;GO:0007626|locomotory behavior;GO:0009410|response to xenobiotic stimulus;GO:0010460|positive regulation of heart rate;GO:0010467|gene expression;GO:0010842|retina layer formation;GO:0015813|L-glutamate transmembrane transport;GO:0018105|peptidyl-serine phosphorylation;GO:0019221|cytokine-mediated signaling pathway;GO:0022008|neurogenesis;GO:0030534|adult behavior;GO:0032148|activation of protein kinase B activity;GO:0034599|cellular response to oxidative stress;GO:0035633|maintenance of permeability of blood-brain barrier;GO:0036293|response to decreased oxygen levels;GO:0036475|neuron death in response to oxidative stress;GO:0042417|dopamine metabolic process;GO:0042883|cysteine transport;GO:0043278|response to morphine;GO:0043524|negative regulation of neuron apoptotic process;GO:0045184|establishment of protein localization;GO:0048514|blood vessel morphogenesis;GO:0048678|response to axon injury;GO:0050808|synapse organization;GO:0051938|L-glutamate import;GO:0060013|righting reflex;GO:0060041|retina development in camera-type eye;GO:0060047|heart contraction;GO:0060291|long-term synaptic potentiation;GO:0061744|motor behavior;GO:0070777|D-aspartate transport;GO:0070778|L-aspartate transmembrane transport;GO:0070779|D-aspartate import across plasma membrane;GO:0070997|neuron death;GO:0071242|cellular response to ammonium ion;GO:0071288|cellular response to mercury ion;GO:0071314|cellular response to cocaine;GO:0071407|cellular response to organic cyclic compound;GO:0071577|zinc ion transmembrane transport;GO:0072347|response to anesthetic;GO:0090313|regulation of protein targeting to membrane;GO:0090461|glutamate homeostasis;GO:0097049|motor neuron apoptotic process;GO:0098712|L-glutamate import across plasma membrane;GO:0098877|neurotransmitter receptor transport to plasma membrane;GO:0140009|L-aspartate import across plasma membrane;GO:1902476|chloride transmembrane transport;GO:1903712|cysteine transmembrane transport;GO:1990708|conditioned place preference;","GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0016324|apical plasma membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0031901|early endosome membrane;GO:0031902|late endosome membrane;GO:0031982|vesicle;GO:0032279|asymmetric synapse;GO:0043025|neuronal cell body;GO:0043083|synaptic cleft;GO:0043197|dendritic spine;GO:0043198|dendritic shaft;GO:0043204|perikaryon;GO:0043679|axon terminus;GO:0045121|membrane raft;GO:0045202|synapse;GO:0055037|recycling endosome;GO:0055038|recycling endosome membrane;GO:0071944|cell periphery;GO:0097386|glial cell projection;GO:0097440|apical dendrite;GO:0098793|presynapse;GO:0099544|perisynaptic space;GO:0150002|distal dendrite;GO:1990635|proximal dendrite;","GO:0005253|anion channel activity;GO:0005313|L-glutamate transmembrane transporter activity;GO:0005314|high-affinity glutamate transmembrane transporter activity;GO:0005515|protein binding;GO:0015108|chloride transmembrane transporter activity;GO:0015183|L-aspartate transmembrane transporter activity;GO:0015501|glutamate:sodium symporter activity;GO:0016595|glutamate binding;GO:0033229|cysteine transmembrane transporter activity;GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0140010|D-aspartate transmembrane transporter activity;","K05612","SLC1A1, EAAT3; solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter), member 1"]
["ENSRNOG00000015448",0,0.042067634,7,0.450313067,0.09341864,-3.420145747,0.021270607,0.01242818,"down","yes","Dipk1c","protein_coding","chr18:78087991-78109904:+","gi|62664711|ref|XP_574179.1|",1825,0,"PREDICTED: protein FAM69C [Rattus norvegicus]","gi|672030959|ref|XM_001061354.5|",2045,0,"PREDICTED: Rattus norvegicus family with sequence similarity 69, member C (Fam69c), mRNA","Q8BQT2",671,0,"Protein FAM69C",".",".",".",".","pfam12260","PIP49_C","Protein-kinase domain of FAM69. This is the C-terminal region of a family of FAM69 proteins from Metazoa and Viridiplantae that are active protein-kinases. The family members have a short transmembrane helix close to the N-terminus, and thereafter are highly enriched with cysteines. FAM69 proteins are localized to the endoplasmic reticulum. Many members also have a short EF-hand, calcium-binding, domain just upstream of the kinase domain. The exact function of the more N-terminal family is uncertain.",".","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000020492",0,0.042067634,7,0.450313067,0.09341864,-3.420145747,0.021270607,0.01242818,"down","yes","Rps27a-ps28","protein_coding","chr18:24242880-24243492:-","gi|13195690|ref|NP_077239.1|",608,{"v":6e-78,"d":"6.00E-78"},"ubiquitin-40S ribosomal protein S27a precursor [Mus musculus]","gi|796616106|ref|NG_042075.1|",372,0,"Rattus norvegicus ribosomal protein S27a, pseudogene 1 (Rps27a-ps1) on chromosome 5","P62982",238,{"v":2E-79,"d":"2.00E-79"},"Ubiquitin-40S ribosomal protein S27a","ECU02g0740i",139,{"v":7e-42,"d":"7.00E-42"},"COG5272","pfam00240","ubiquitin","Ubiquitin family. This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) Nedd8, Elongin B, Rub1, and Parkin. A number of them are thought to carry a distinctive five-residue motif termed the proteasome-interacting motif (PIM), which may have a biologically significant role in protein delivery to proteasomes and recruitment of proteasomes to transcription sites.","GO:0006412|translation;",".","GO:0046872|metal ion binding;",".","."]
["ENSRNOG00000022335",0,0.042067634,7,0.450313067,0.09341864,-3.420145747,0.021270607,0.01242818,"down","yes","Rad21l1","protein_coding","chr3:140160118-140188298:-","gi|392339613|ref|XP_002726296.2|",2714,0,"PREDICTED: double-strand-break repair protein rad21-like protein 1 [Rattus norvegicus]","gi|564302663|ref|XM_002726250.3|",2317,0,"PREDICTED: Rattus norvegicus RAD21-like 1 (S. pombe) (Rad21l1), mRNA","A2AU37",931,0,"Double-strand-break repair protein rad21-like protein 1",".",".",".",".","pfam04825","Rad21_Rec8_N","N terminus of Rad21 / Rec8 like protein. This family represents a conserved N-terminal region found in eukaryotic cohesins of the Rad21, Rec8 and Scc1 families. Members of this family mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation.","GO:0000724|double-strand break repair via homologous recombination;GO:0006302|double-strand break repair;GO:0007064|mitotic sister chromatid cohesion;GO:0007129|synapsis;GO:0007130|synaptonemal complex assembly;GO:0007283|spermatogenesis;GO:0009566|fertilization;GO:0070197|meiotic attachment of telomere to nuclear envelope;GO:0072520|seminiferous tubule development;GO:1990414|replication-born double-strand break repair via sister chromatid exchange;","GO:0000794|condensed nuclear chromosome;GO:0000795|synaptonemal complex;GO:0000800|lateral element;GO:0005634|nucleus;GO:0005694|chromosome;GO:0030893|meiotic cohesin complex;GO:0034990|nuclear mitotic cohesin complex;GO:0034991|nuclear meiotic cohesin complex;","GO:0003682|chromatin binding;",".","."]
["ENSRNOG00000024709",0,0.042067634,7,0.450313067,0.09341864,-3.420145747,0.021270607,0.01242818,"down","yes","Vwde","protein_coding","chr4:41455281-41533374:-","gi|672018235|ref|XP_008773934.1|",9152,0,"PREDICTED: von Willebrand factor D and EGF domain-containing protein [Rattus norvegicus]","gi|672018234|ref|XM_008775712.1|",5292,0,"PREDICTED: Rattus norvegicus von Willebrand factor D and EGF domains (Vwde), mRNA","Q8N2E2",1796,0,"von Willebrand factor D and EGF domain-containing protein",".",".",".",".","pfam00094","VWD","von Willebrand factor type D domain. Luciferin-2-monooxygenase from Vargula hilgendorfii contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.",".",".",".",".","."]
["ENSRNOG00000027478",0,0.042067634,7,0.450313067,0.09341864,-3.420145747,0.021270607,0.01242818,"down","yes","Krtap11-1","protein_coding","chr11:28810341-28810892:-","gi|392332254|ref|XP_003752520.1|",896,{"v":1e-120,"d":"1.00E-120"},"PREDICTED: keratin-associated protein 11-1 [Rattus norvegicus]","gi|672025861|ref|XM_003752472.3|",552,0,"PREDICTED: Rattus norvegicus keratin associated protein 11-1 (Krtap11-1), mRNA","Q8IUC1",241,{"v":9e-80,"d":"9.00E-80"},"Keratin-associated protein 11-1",".",".",".",".","pfam05287","PMG","PMG protein. This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteristic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.",".",".",".",".","."]
["ENSRNOG00000028404",0,0.042067634,7,0.450313067,0.09341864,-3.420145747,0.021270607,0.01242818,"down","yes","Ppp1r1b","protein_coding","chr10:83347731-83356775:+","gi|61889054|ref|NP_612530.1|",781,{"v":4e-97,"d":"4.00E-97"},"protein phosphatase 1 regulatory subunit 1B [Rattus norvegicus]","gi|61889053|ref|NM_138521.1|",1739,0,"Rattus norvegicus protein phosphatase 1, regulatory (inhibitor) subunit 1B (Ppp1r1b), mRNA","Q6J4I0",305,{"v":1e-98,"d":"1.00E-98"},"Protein phosphatase 1 regulatory subunit 1B",".",".",".",".","pfam05395","DARPP-32","Protein phosphatase inhibitor 1/DARPP-32. This family consists of several mammalian protein phosphatase inhibitor 1 (IPP-1) and dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32) proteins. Protein phosphatase inhibitor-1 is involved in signal transduction and is an endogenous inhibitor of protein phosphatase-1. It has been demonstrated that DARPP-32, if phosphorylated, can inhibit protein-phosphatase-1. DARPP-32 has a key role in many neurotransmitter pathways throughout the brain and has been shown to be involved in controlling receptors, ion channels and other physiological factors including the brain's response to drugs of abuse, such as cocaine, opiates and nicotine. DARPP-32 is reciprocally regulated by the two neurotransmitters that are most often implicated in schizophrenia - dopamine and glutamate. Dopamine activates DARPP-32 through the D1 receptor pathway and disables DARPP-32 through the D2 receptor. Glutamate, acting through the N-methyl-d-aspartate receptor, renders DARPP-32 inactive. A mutant form of DARPP-32 has been linked with gastric cancers.","GO:0001975|response to amphetamine;GO:0006351|transcription, DNA-templated;GO:0007613|memory;GO:0007621|negative regulation of female receptivity;GO:0007626|locomotory behavior;GO:0008542|visual learning;GO:0032515|negative regulation of phosphoprotein phosphatase activity;GO:0035094|response to nicotine;GO:0035556|intracellular signal transduction;GO:0042220|response to cocaine;GO:0043278|response to morphine;GO:0043987|histone H3-S10 phosphorylation;GO:0048148|behavioral response to cocaine;GO:0071314|cellular response to cocaine;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0043025|neuronal cell body;GO:0044326|dendritic spine neck;GO:0044327|dendritic spine head;GO:0098794|postsynapse;GO:0098978|glutamatergic synapse;","GO:0004864|protein phosphatase inhibitor activity;GO:0031748|D1 dopamine receptor binding;GO:0031749|D2 dopamine receptor binding;GO:0031750|D3 dopamine receptor binding;GO:0031751|D4 dopamine receptor binding;GO:0031752|D5 dopamine receptor binding;","K15494","PPP1R1B, DARPP32; protein phosphatase 1 regulatory subunit 1B"]
["ENSRNOG00000029844",0,0.042067634,7,0.450313067,0.09341864,-3.420145747,0.021270607,0.01242818,"down","yes","Akr1c2","protein_coding","chr17:65759788-65775764:-","gi|564392028|ref|XP_006254245.1|",1715,0,"PREDICTED: aldo-keto reductase family 1 member C21 isoform X1 [Rattus norvegicus]","gi|672082374|ref|XM_006254184.2|",979,0,"PREDICTED: Rattus norvegicus aldo-keto reductase family 1, member C2 (Akr1c2), transcript variant X2, mRNA","Q6AYQ2",653,0,"Aldo-keto reductase family 1 member C21","YOR120w",191,{"v":2E-55,"d":"2.00E-55"},"COG0656","pfam00248","Aldo_ket_red","Aldo/keto reductase family. This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.","GO:0006693|prostaglandin metabolic process;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007586|digestion;GO:0008202|steroid metabolic process;GO:0008284|positive regulation of cell proliferation;GO:0030855|epithelial cell differentiation;GO:0042448|progesterone metabolic process;GO:0044597|daunorubicin metabolic process;GO:0044598|doxorubicin metabolic process;GO:0051897|positive regulation of protein kinase B signaling;GO:0071395|cellular response to jasmonic acid stimulus;GO:0071799|cellular response to prostaglandin D stimulus;","GO:0005829|cytosol;","GO:0004032|alditol:NADP+ 1-oxidoreductase activity;GO:0005496|steroid binding;GO:0016229|steroid dehydrogenase activity;GO:0016655|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0018636|phenanthrene 9,10-monooxygenase activity;GO:0031406|carboxylic acid binding;GO:0032052|bile acid binding;GO:0033764|steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0047023|androsterone dehydrogenase activity;GO:0047024|5alpha-androstane-3beta,17beta-diol dehydrogenase activity;GO:0047086|ketosteroid monooxygenase activity;GO:0047115|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity;GO:0047834|D-threo-aldose 1-dehydrogenase activity;GO:0070401|NADP+ binding;GO:0070402|NADPH binding;GO:0072555|17-beta-ketosteroid reductase activity;GO:0072582|17-beta-hydroxysteroid dehydrogenase (NADP+) activity;GO:1902121|lithocholic acid binding;",".","."]
["ENSRNOG00000030299",0,0.042067634,7,0.450313067,0.09341864,-3.420145747,0.021270607,0.01242818,"down","yes","AABR07024742.1","protein_coding","chr16:12476735-12477253:+","gi|6678437|ref|NP_033455.1|",849,{"v":7E-114,"d":"7.00E-114"},"translationally-controlled tumor protein [Mus musculus]","gi|298915896|emb|FQ222827.1|",474,0,"Rattus norvegicus TL0ADA19YH23 mRNA sequence","P63029",331,{"v":2e-115,"d":"2.00E-115"},"Translationally-controlled tumor protein",".",".",".",".","pfam00838","TCTP","Translationally controlled tumor protein.",".",".",".",".","."]
["ENSRNOG00000037375",0,0.042067634,7,0.450313067,0.09341864,-3.420145747,0.021270607,0.01242818,"down","yes","RGD1565410","protein_coding","chr7:107011588-107163788:-","gi|564360466|ref|XP_006241832.1|",630,{"v":6e-77,"d":"6.00E-77"},"PREDICTED: uncharacterized protein LOC503162 isoform X1, partial [Rattus norvegicus]","gi|166157531|ref|NM_001113792.1|",714,0,"Rattus norvegicus similar to Ly6-C antigen gene (RGD1565410), mRNA","Q63317",163,{"v":2E-46,"d":"2.00E-46"},"Lymphocyte antigen 6B",".",".",".",".","pfam00021","UPAR_LY6","u-PAR/Ly-6 domain. This extracellular disulphide bond rich domain is related to pfam00087.","GO:0095500|acetylcholine receptor signaling pathway;GO:2000272|negative regulation of signaling receptor activity;","GO:0005886|plasma membrane;GO:0045202|synapse;","GO:0030550|acetylcholine receptor inhibitor activity;GO:0033130|acetylcholine receptor binding;",".","."]
["ENSRNOG00000041492",0,0.042067634,7,0.450313067,0.09341864,-3.420145747,0.021270607,0.01242818,"down","yes","Mir1249","miRNA","chr7:116075593-116075712:-","gi|817269686|ref|XP_012304901.1|",165,{"v":6e-13,"d":"6.00E-13"},"PREDICTED: uncharacterized protein LOC105715205 [Aotus nancymaae]","gi|312147370|ref|NR_037390.1|",120,{"v":5e-55,"d":"5.00E-55"},"Rattus norvegicus microRNA 1249 (Mir1249), microRNA",".",".",".",".",".",".",".",".","pfam06532","DUF1109","Protein of unknown function (DUF1109). This family consists of several hypothetical bacterial proteins of unknown function.",".",".",".",".","."]
["ENSRNOG00000047481",0,0.042067634,7,0.450313067,0.09341864,-3.420145747,0.021270607,0.01242818,"down","yes","Kiss1","protein_coding","chr13:44774823-44780612:+","gi|32140194|ref|NP_859043.1|",580,{"v":4e-72,"d":"4.00E-72"},"metastasis-suppressor KiSS-1 precursor [Rattus norvegicus]","gi|672073687|ref|XM_008769443.1|",804,0,"PREDICTED: Rattus norvegicus KiSS-1 metastasis-suppressor (Kiss1), transcript variant X1, mRNA","Q7TSB7",228,{"v":1E-73,"d":"1.00E-73"},"Metastasis-suppressor KiSS-1",".",".",".",".","pfam15152","Kisspeptin","Kisspeptin.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0008285|negative regulation of cell proliferation;GO:0030336|negative regulation of cell migration;GO:0033686|positive regulation of luteinizing hormone secretion;GO:0043410|positive regulation of MAPK cascade;GO:0046697|decidualization;GO:0050806|positive regulation of synaptic transmission;GO:0051482|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway;GO:0060112|generation of ovulation cycle rhythm;GO:0060124|positive regulation of growth hormone secretion;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0016324|apical plasma membrane;GO:0043005|neuron projection;GO:0043025|neuronal cell body;","GO:0001664|G protein-coupled receptor binding;GO:0031773|kisspeptin receptor binding;","K23140","KISS1; metastasis-suppressor KiSS-1"]
["ENSRNOG00000050121",0,0.042067634,7,0.450313067,0.09341864,-3.420145747,0.021270607,0.01242818,"down","yes","Rhag","protein_coding","chr9:20069807-20097836:-","gi|149069231|gb|EDM18672.1|",2029,0,"Rhesus blood group-associated A glycoprotein [Rattus norvegicus]","gi|40254762|ref|NM_023022.2|",2126,0,"Rattus norvegicus Rh-associated glycoprotein (Rhag), mRNA","Q7TNK7",783,0,"Ammonium transporter Rh type A","sll1017",64.3,{"v":5e-10,"d":"5.00E-10"},"COG0004","pfam00909","Ammonium_transp","Ammonium Transporter Family.","GO:0006873|cellular ion homeostasis;GO:0008150|biological_process;GO:0015670|carbon dioxide transport;GO:0015696|ammonium transport;GO:0048821|erythrocyte development;GO:0060586|multicellular organismal iron ion homeostasis;GO:0072488|ammonium transmembrane transport;GO:0098662|inorganic cation transmembrane transport;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;","GO:0003674|molecular_function;GO:0008519|ammonium transmembrane transporter activity;GO:0022840|leak channel activity;GO:0030506|ankyrin binding;","K06580","SLC42A, RHAG, RHBG, RHCG, CD241; ammonium transporter Rh"]
["ENSRNOG00000053330",0,0.042067634,7,0.450313067,0.09341864,-3.420145747,0.021270607,0.01242818,"down","yes","U6","snRNA","chr17:17933185-17933292:+","gi|444516109|gb|ELV11053.1|",107,2e-07,"Ankyrin repeat and death domain-containing protein 1B [Tupaia chinensis]","gi|982951672|ref|XM_015475747.1|",104,{"v":3e-46,"d":"3.00E-46"},"PREDICTED: Bos taurus ataxin 1 like (ATXN1L), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam03772","Competence","Competence protein. Members of this family are integral membrane proteins with 6 predicted transmembrane helices. Some members of this family have been shown to be essential for bacterial competence in uptake of extracellular DNA. These proteins may transport DNA across the cell membrane. These proteins contain a highly conserved motif in the amino terminal transmembrane region that has two histidines that may form a metal binding site.",".",".",".",".","."]
["ENSRNOG00000056701",0,0.042067634,7,0.450313067,0.09341864,-3.420145747,0.021270607,0.01242818,"down","yes","Gtf2a2","protein_coding","chr8:70662428-70675569:+","gi|74224980|dbj|BAE38203.1|",592,{"v":4E-73,"d":"4.00E-73"},"unnamed protein product [Mus musculus]","gi|672062251|ref|XM_006243380.2|",649,0,"PREDICTED: Rattus norvegicus general transcription factor IIA, 2 (Gtf2a2), transcript variant X1, mRNA","O08950",223,{"v":2e-71,"d":"2.00E-71"},"Transcription initiation factor IIA subunit 2","SPCC553.11c",111,{"v":4e-29,"d":"4.00E-29"},"COG5123","pfam02751","TFIIA_gamma_C","Transcription initiation factor IIA, gamma subunit. Accurate transcription in vivo requires at least six general transcription initiation factors, in addition to RNA polymerase II. Transcription initiation factor IIA (TFIIA) is a multimeric protein which facilitates the binding of TFIID to the TATA box. The C-terminal domain of the gamma subunit is a 12 stranded beta-barrel.","GO:0006366|transcription by RNA polymerase II;GO:0006367|transcription initiation from RNA polymerase II promoter;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051123|RNA polymerase II preinitiation complex assembly;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005669|transcription factor TFIID complex;GO:0005672|transcription factor TFIIA complex;GO:0030054|cell junction;","GO:0016251|RNA polymerase II general transcription initiation factor activity;GO:0017025|TBP-class protein binding;GO:0042803|protein homodimerization activity;GO:0046982|protein heterodimerization activity;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;","K03123","TFIIA2, GTF2A2, TOA2; transcription initiation factor TFIIA small subunit"]
["ENSRNOG00000056857",0,0.042067634,7,0.450313067,0.09341864,-3.420145747,0.021270607,0.01242818,"down","yes","Gm23747","snoRNA","chr7:107446145-107446279:+",".",".",".",".","gi|908662467|tpe|LN872108.1|",58,{"v":2e-20,"d":"2.00E-20"},"TPA: Mus musculus SNORA17 (ACA17) gene for small nucleolar RNA SNORA17 (ACA17)",".",".",".",".",".",".",".",".","pfam10261","Scs3p","Inositol phospholipid synthesis and fat-storage-inducing TM. This is a family of transmembrane proteins which are variously annotated as possibly being inositol phospholipid synthesis protein and fat-storage-inducing. The members are conserved from yeasts to humans and are localized to the endoplasmic reticulum where they are involved in triglyceride lipid droplet formation.",".",".",".",".","."]
["ENSRNOG00000061131",0,0.042067634,7,0.450313067,0.09341864,-3.420145747,0.021270607,0.01242818,"down","yes","U6","snRNA","chr13:92897631-92897736:+",".",".",".",".","gi|354799747|gb|JN964248.1|",75,{"v":4e-30,"d":"4.00E-30"},"Mus musculus targeted non-conditional, lacZ-tagged mutant allele E130309F12Rik:tm1e(EUCOMM)Hmgu; transgenic",".",".",".",".",".",".",".",".","pfam00757","Furin-like","Furin-like cysteine rich region.",".",".",".",".","."]
["ENSRNOG00000062358",0,0.042067634,7,0.450313067,0.09341864,-3.420145747,0.021270607,0.01242818,"down","yes","Lilrb3l","protein_coding","chr1:65415946-65422853:+","gi|564325666|ref|XP_006228094.1|",3482,0,"PREDICTED: leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3-like isoform X2 [Rattus norvegicus]","gi|672034461|ref|XM_006228032.2|",2260,0,"PREDICTED: Rattus norvegicus leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3-like (Lilrb3l), transcript variant X2, mRNA","A0A0G2KBC9",1070,0,"Leukocyte immunoglobulin-like receptor subfamily B member 3-like",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.",".",".",".",".","."]
["ENSRNOG00000063029",0,0.042067634,7,0.450313067,0.09341864,-3.420145747,0.021270607,0.01242818,"down","yes","ENSRNOG00000063029","lncRNA","chr1:193753396-193759800:+",".",".",".",".","gi|672038915|ref|XM_008760004.1|",581,0,"PREDICTED: Rattus norvegicus janus kinase and microtubule interacting protein 3 (Jakmip3), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam07142","DUF1388","Repeat of unknown function (DUF1388). This family consists of several repeats of around 29 residues in length. Members of this family are found in the variable surface lipoproteins in Mycoplasma bovis and in mammalian neurofilament triplet H (NefH or NF-H) proteins. This repeat contains several Lys-Ser-Pro (KSP) motifs and in NefH these are thought to function as the main target for neurofilament directed protein kinases in vivo.",".",".",".",".","."]
["ENSRNOG00000063167",0,0.042067634,7,0.450313067,0.09341864,-3.420145747,0.021270607,0.01242818,"down","yes","Hist1h3b","protein_coding","chr17:42723450-42723911:+","gi|564320036|ref|XP_002725328.3|",746,{"v":4e-96,"d":"4.00E-96"},"PREDICTED: uncharacterized protein LOC680498 [Rattus norvegicus]","gi|672082321|ref|XM_001057443.4|",462,0,"PREDICTED: Rattus norvegicus similar to CG31613-PA (LOC680498), mRNA","Q6LED0",275,{"v":3e-94,"d":"3.00E-94"},"Histone H3.1",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.",".",".",".",".","."]
["ENSRNOG00000063174",0,0.042067634,7,0.450313067,0.09341864,-3.420145747,0.021270607,0.01242818,"down","yes","ENSRNOG00000063174","protein_coding","chr17:54800564-54803205:-","gi|564391905|ref|XP_006254195.1|",1436,0,"PREDICTED: ral guanine nucleotide dissociation stimulator-like isoform X1 [Rattus norvegicus]","gi|672082245|ref|XM_006254133.2|",1250,0,"PREDICTED: Rattus norvegicus similar to Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS) (LOC686142), transcript variant X1, mRNA","Q03386",93.2,{"v":6e-19,"d":"6.00E-19"},"Ral guanine nucleotide dissociation stimulator",".",".",".",".","pfam00618","RasGEF_N","RasGEF N-terminal motif. A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this motif/domain N-terminal to the RasGef (Cdc25-like) domain.",".",".",".",".","."]
["ENSRNOG00000063537",0,0.042067634,7,0.450313067,0.09341864,-3.420145747,0.021270607,0.01242818,"down","yes","ENSRNOG00000063537","lncRNA","chr4:90149070-90154178:-","gi|149037052|gb|EDL91613.1|",230,{"v":9e-20,"d":"9.00E-20"},"rCG55335 [Rattus norvegicus]","gi|672018386|ref|XR_345863.2|",1520,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102556581 (LOC102556581), transcript variant X1, ncRNA",".",".",".",".",".",".",".",".","pfam15498","Dendrin","Nephrin and CD2AP-binding protein, Dendrin. Dendrin is a family of eukaryotic proteins found in the podocytes of the kidneys. Dendrin, originally identified in telencephalic dendrites, is a constituent of the slit diaphragm, SD, complex of podocytes, where it directly binds to nephrin and CD2AP. Kidney podocytes and their slit diaphragms (SDs) form the final barrier to urinary protein loss. SD proteins also participate in intracellular signalling pathways. Dendrin appears to prevent programmed cell death (apoptosis) through its binding to nephrin. The SD protein nephrin serves as a component of a signalling complex that directly links podocyte junctional integrity to actin cytoskeletal dynamics. Thus, dendrin is identified as an SD family with proapoptotic signalling properties that accumulates in the podocyte nucleus in response to glomerular injury.",".",".",".",".","."]
["ENSRNOG00000063719",0,0.042067634,7,0.450313067,0.09341864,-3.420145747,0.021270607,0.01242818,"down","yes","ENSRNOG00000063719","lncRNA","chr5:145798064-145800053:-",".",".",".",".","gi|672019997|ref|XM_001065500.4|",302,{"v":8e-155,"d":"8.00E-155"},"PREDICTED: Rattus norvegicus G patch domain containing 3 (Gpatch3), mRNA",".",".",".",".",".",".",".",".","pfam09381","Porin_OmpG","Outer membrane protein G (OmpG). Porins are channel proteins in the outer membrane of gram negative bacteria which mediate the uptake of molecules required for growth and survival. Escherichia coli OmpG forms a 14 stranded beta-barrel and in contrast to most porins, appears to function as a monomer. The central pore of OmpG is wider than other Escherichia coli porins and it is speculated that it may form a non-specific channel for the transport of larger oligosaccharides.",".",".",".",".","."]
["ENSRNOG00000065176",0,0.042067634,7,0.450313067,0.09341864,-3.420145747,0.021270607,0.01242818,"down","yes","ENSRNOG00000065176","lncRNA","chr7:132361770-132363309:+",".",".",".",".","gi|110347614|gb|AC115640.8|",940,0,"Rattus norvegicus BAC CH230-210B21 () complete sequence",".",".",".",".",".",".",".",".","pfam13166","AAA_13","AAA domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. This family includes the PrrC protein that is thought to be the active component of the anticodon nuclease.",".",".",".",".","."]
["ENSRNOG00000067792",0,0.042067634,7,0.450313067,0.09341864,-3.420145747,0.021270607,0.01242818,"down","yes","ENSRNOG00000067792","protein_coding","chr1:238567690-238602876:-","gi|26337919|dbj|BAC32645.1|",558,{"v":4e-62,"d":"4.00E-62"},"unnamed protein product [Mus musculus]","gi|260441710|gb|AC120070.6|",2690,0,"Rattus norvegicus BAC CH230-481C18 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q64458",103,{"v":2e-21,"d":"2.00E-21"},"Cytochrome P450 2C29",".",".",".",".","pfam02337","Gag_p10","Retroviral GAG p10 protein. This family consists of various retroviral GAG (core) polyproteins and encompasses the p10 region producing the p10 protein upon proteolytic cleavage of GAG by retroviral protease. The p10 or matrix protein (MA) is associated with the virus envelope glycoproteins in most mammalian retroviruses and may be involved in virus particle assembly, transport and budding. Some of the GAG polyproteins have alternate cleavage sites leading to the production of alternative and longer cleavage products (e.g. p19) the alignment of this family only covers the approximately N-terminal (GAG) 100 amino acid region of homology to p10.",".",".",".",".","."]
["ENSRNOG00000005794",3,0.252405806,14,0.900626135,0.28025592,-1.835183247,0.021441045,0.012508645,"down","yes","Slc10a1","protein_coding","chr6:100613045-100626670:-","gi|8394279|ref|NP_058743.1|",1725,0,"sodium/bile acid cotransporter [Rattus norvegicus]","gi|8394278|ref|NM_017047.1|",1657,0,"Rattus norvegicus solute carrier family 10 member 1 (Slc10a1), mRNA","P26435",666,0,"Sodium/bile acid cotransporter","SA2112",92,{"v":1e-19,"d":"1.00E-19"},"COG0385","pfam01758","SBF","Sodium Bile acid symporter family. This family consists of Na+/bile acid co-transporters. These transmembrane proteins function in the liver in the uptake of bile acids from portal blood plasma a process mediated by the co-transport of Na+. Also in the family is ARC3 from S. cerevisiae, a putative transmembrane protein involved in resistance to arsenic compounds.","GO:0006814|sodium ion transport;GO:0010468|regulation of gene expression;GO:0014070|response to organic cyclic compound;GO:0015721|bile acid and bile salt transport;GO:0031667|response to nutrient levels;GO:0038183|bile acid signaling pathway;GO:0045471|response to ethanol;GO:0055085|transmembrane transport;GO:0071466|cellular response to xenobiotic stimulus;GO:0120188|regulation of bile acid secretion;GO:1904486|response to 17alpha-ethynylestradiol;","GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;","GO:0008508|bile acid:sodium symporter activity;GO:0015125|bile acid transmembrane transporter activity;","K14341","SLC10A1, NTCP; solute carrier family 10 (sodium/bile acid cotransporter), member 1"]
["ENSRNOG00000006255",3,0.252405806,14,0.900626135,0.28025592,-1.835183247,0.021441045,0.012508645,"down","yes","Nipal4","protein_coding","chr10:30583926-30600640:-","gi|157821563|ref|NP_001100465.1|",1859,0,"magnesium transporter NIPA4 [Rattus norvegicus]","gi|157821562|ref|NM_001106995.1|",3143,0,"Rattus norvegicus NIPA-like domain containing 4 (Nipal4), mRNA","Q8BZF2",682,0,"Magnesium transporter NIPA4",".",".",".",".","pfam05653","Mg_trans_NIPA","Magnesium transporter NIPA. NIPA (nonimprinted in Prader-Willi/Angelman syndrome) is a family of integral membrane proteins which function as magnesium transporters.","GO:0015693|magnesium ion transport;GO:1903830|magnesium ion transmembrane transport;","GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0015095|magnesium ion transmembrane transporter activity;","K22733","NIPA, SLC57A2S; magnesium transporter"]
["ENSRNOG00000010085",3,0.252405806,14,0.900626135,0.28025592,-1.835183247,0.021441045,0.012508645,"down","yes","Cldn10","protein_coding","chr15:95862760-95954526:+","gi|157821473|ref|NP_001099528.1|",1492,0,"claudin-10 [Rattus norvegicus]","gi|157821472|ref|NM_001106058.1|",1331,0,"Rattus norvegicus claudin 10 (Cldn10), mRNA","Q9Z0S6",462,{"v":2e-161,"d":"2.00E-161"},"Claudin-10",".",".",".",".","pfam00822","PMP22_Claudin","PMP-22/EMP/MP20/Claudin family.","GO:0007155|cell adhesion;GO:0043269|regulation of ion transport;GO:0070830|bicellular tight junction assembly;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005923|bicellular tight junction;GO:0016021|integral component of membrane;","GO:0005198|structural molecule activity;","K06087","CLDN; claudin"]
["ENSRNOG00000011518",3,0.252405806,14,0.900626135,0.28025592,-1.835183247,0.021441045,0.012508645,"down","yes","Dusp26","protein_coding","chr16:61041792-61049051:-","gi|640815631|ref|XP_008064591.1|",973,{"v":8e-126,"d":"8.00E-126"},"PREDICTED: dual specificity protein phosphatase 26 [Tarsius syrichta]","gi|59891426|ref|NM_001012352.1|",1599,0,"Rattus norvegicus dual specificity phosphatase 26 (putative) (Dusp26), mRNA","Q5FVI9",368,{"v":1e-123,"d":"1.00E-123"},"Dual specificity protein phosphatase 26","SPBC17A3.06",63.2,{"v":5e-10,"d":"5.00E-10"},"COG2453","pfam00782","DSPc","Dual specificity phosphatase, catalytic domain. Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a \"recognition\" region.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006470|protein dephosphorylation;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0043409|negative regulation of MAPK cascade;GO:0044387|negative regulation of protein kinase activity by regulation of protein phosphorylation;GO:0045785|positive regulation of cell adhesion;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:1902310|positive regulation of peptidyl-serine dephosphorylation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;","GO:0002039|p53 binding;GO:0004721|phosphoprotein phosphatase activity;GO:0004725|protein tyrosine phosphatase activity;GO:0008138|protein tyrosine/serine/threonine phosphatase activity;GO:0033549|MAP kinase phosphatase activity;GO:0036424|L-phosphoserine phosphatase activity;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;","K14165","K14165; atypical dual specificity phosphatase [EC:3.1.3.16 3.1.3.48]"]
["ENSRNOG00000013953",3,0.252405806,14,0.900626135,0.28025592,-1.835183247,0.021441045,0.012508645,"down","yes","Ntrk1","protein_coding","chr2:173236963-173253770:-","gi|11024666|ref|NP_067600.1|",3923,0,"high affinity nerve growth factor receptor precursor [Rattus norvegicus]","gi|11024665|ref|NM_021589.1|",2617,0,"Rattus norvegicus neurotrophic tyrosine kinase, receptor, type 1 (Ntrk1), mRNA","P35739",1515,0,"High affinity nerve growth factor receptor",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001934|positive regulation of protein phosphorylation;GO:0006468|protein phosphorylation;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007178|transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0007275|multicellular organism development;GO:0007399|nervous system development;GO:0007411|axon guidance;GO:0007568|aging;GO:0007611|learning or memory;GO:0007623|circadian rhythm;GO:0008285|negative regulation of cell proliferation;GO:0009314|response to radiation;GO:0009410|response to xenobiotic stimulus;GO:0010623|programmed cell death involved in cell development;GO:0010976|positive regulation of neuron projection development;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0014823|response to activity;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0019233|sensory perception of pain;GO:0021553|olfactory nerve development;GO:0030183|B cell differentiation;GO:0031175|neuron projection development;GO:0031667|response to nutrient levels;GO:0033674|positive regulation of kinase activity;GO:0035094|response to nicotine;GO:0038083|peptidyl-tyrosine autophosphorylation;GO:0038179|neurotrophin signaling pathway;GO:0038180|nerve growth factor signaling pathway;GO:0042490|mechanoreceptor differentiation;GO:0043068|positive regulation of programmed cell death;GO:0043410|positive regulation of MAPK cascade;GO:0043524|negative regulation of neuron apoptotic process;GO:0043547|positive regulation of GTPase activity;GO:0045471|response to ethanol;GO:0045766|positive regulation of angiogenesis;GO:0046579|positive regulation of Ras protein signal transduction;GO:0046777|protein autophosphorylation;GO:0048011|neurotrophin TRK receptor signaling pathway;GO:0048013|ephrin receptor signaling pathway;GO:0048485|sympathetic nervous system development;GO:0048666|neuron development;GO:0048678|response to axon injury;GO:0050965|detection of temperature stimulus involved in sensory perception of pain;GO:0050966|detection of mechanical stimulus involved in sensory perception of pain;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051599|response to hydrostatic pressure;GO:0051602|response to electrical stimulus;GO:0051896|regulation of protein kinase B signaling;GO:0051965|positive regulation of synapse assembly;GO:0051968|positive regulation of synaptic transmission, glutamatergic;GO:0060009|Sertoli cell development;GO:0060384|innervation;GO:0060385|axonogenesis involved in innervation;GO:0061368|behavioral response to formalin induced pain;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071316|cellular response to nicotine;GO:0071363|cellular response to growth factor stimulus;GO:1901215|negative regulation of neuron death;GO:1990090|cellular response to nerve growth factor stimulus;","GO:0000139|Golgi membrane;GO:0005737|cytoplasm;GO:0005769|early endosome;GO:0005770|late endosome;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0030424|axon;GO:0030425|dendrite;GO:0031410|cytoplasmic vesicle;GO:0031901|early endosome membrane;GO:0031902|late endosome membrane;GO:0032991|protein-containing complex;GO:0043025|neuronal cell body;GO:0043235|receptor complex;GO:0055037|recycling endosome;GO:0055038|recycling endosome membrane;","GO:0004675|transmembrane receptor protein serine/threonine kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0005004|GPI-linked ephrin receptor activity;GO:0005030|neurotrophin receptor activity;GO:0005166|neurotrophin p75 receptor binding;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0010465|nerve growth factor receptor activity;GO:0019900|kinase binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0043121|neurotrophin binding;GO:0048406|nerve growth factor binding;","K03176","NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]"]
["ENSRNOG00000016388",3,0.252405806,14,0.900626135,0.28025592,-1.835183247,0.021441045,0.012508645,"down","yes","Sphkap","protein_coding","chr9:84510964-84657559:-","gi|564369074|ref|XP_006245296.1|",8737,0,"PREDICTED: A-kinase anchor protein SPHKAP isoform X5 [Rattus norvegicus]","gi|672065639|ref|XM_006245234.2|",5215,0,"PREDICTED: Rattus norvegicus SPHK1 interactor, AKAP domain containing (Sphkap), transcript variant X5, mRNA","P0C6C0",3224,0,"A-kinase anchor protein SPHKAP",".",".",".",".","pfam05716","AKAP_110","A-kinase anchor protein 110 kDa (AKAP 110). This family consists of several mammalian protein kinase A anchoring protein 3 (PRKA3) or A-kinase anchor protein 110 kDa (AKAP 110) sequences. Agents that increase intracellular cAMP are potent stimulators of sperm motility. Anchoring inhibitor peptides, designed to disrupt the interaction of the cAMP-dependent protein kinase A (PKA) with A kinase-anchoring proteins (AKAPs), are potent inhibitors of sperm motility. PKA anchoring is a key biochemical mechanism controlling motility. AKAP110 shares compartments with both RI and RII isoforms of PKA and may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.",".","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0030018|Z disc;","GO:0051018|protein kinase A binding;",".","."]
["ENSRNOG00000054576",3,0.252405806,14,0.900626135,0.28025592,-1.835183247,0.021441045,0.012508645,"down","yes","Gsdmc","protein_coding","chr7:95594015-95611344:-","gi|564360024|ref|XP_006241693.1|",2497,0,"PREDICTED: gasdermin-C isoform X1 [Rattus norvegicus]","gi|672059184|ref|XM_006241631.2|",1891,0,"PREDICTED: Rattus norvegicus gasdermin C (Gsdmc), transcript variant X1, mRNA","P85967",934,0,"Gasdermin-C",".",".",".",".","pfam04598","Gasdermin","Gasdermin family. The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein","GO:0012501|programmed cell death;GO:0042742|defense response to bacterium;GO:0070269|pyroptosis;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0001786|phosphatidylserine binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0070273|phosphatidylinositol-4-phosphate binding;","K22143","GSDMC; gasdermin-C"]
["ENSRNOG00000058780",3,0.252405806,14,0.900626135,0.28025592,-1.835183247,0.021441045,0.012508645,"down","yes","Igfbp1","protein_coding","chr14:82047415-82052482:+","gi|6981080|ref|NP_037276.1|",1446,0,"insulin-like growth factor-binding protein 1 precursor [Rattus norvegicus]","gi|6981079|ref|NM_013144.1|",1492,0,"Rattus norvegicus insulin-like growth factor binding protein 1 (Igfbp1), mRNA","P21743",561,0,"Insulin-like growth factor-binding protein 1",".",".",".",".","pfam00086","Thyroglobulin_1","Thyroglobulin type-1 repeat. Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.","GO:0006006|glucose metabolic process;GO:0007568|aging;GO:0008286|insulin receptor signaling pathway;GO:0030307|positive regulation of cell growth;GO:0042246|tissue regeneration;GO:0043567|regulation of insulin-like growth factor receptor signaling pathway;GO:0048015|phosphatidylinositol-mediated signaling;","GO:0005615|extracellular space;GO:0005794|Golgi apparatus;","GO:0005520|insulin-like growth factor binding;GO:0031994|insulin-like growth factor I binding;GO:0031995|insulin-like growth factor II binding;","K23578","IGFBP1; insulin-like growth factor-binding protein 1"]
["ENSRNOG00000068315",3,0.252405806,14,0.900626135,0.28025592,-1.835183247,0.021441045,0.012508645,"down","yes","ENSRNOG00000068315","lncRNA","chrX:149054731-149063744:-",".",".",".",".","gi|672013978|ref|XR_598963.1|",547,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102556693 (LOC102556693), transcript variant X3, ncRNA",".",".",".",".",".",".",".",".","pfam13030","DUF3891","Protein of unknown function (DUF3891). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and archaea. Proteins in this family are approximately 250 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000010092",4,0.336541075,16,1.029287011,0.32696524,-1.612790825,0.024712852,0.014172917,"down","yes","Magix","protein_coding","chrX:14824188-14831045:+","gi|62078955|ref|NP_001014131.1|",1539,0,"PDZ domain-containing protein MAGIX [Rattus norvegicus]","gi|62078954|ref|NM_001014109.1|",1418,0,"Rattus norvegicus MAGI family member, X-linked (Magix), mRNA",".",".",".",".",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.",".",".",".",".","."]
["ENSRNOG00000015293",4,0.336541075,16,1.029287011,0.32696524,-1.612790825,0.024712852,0.014172917,"down","yes","Dynlt2","protein_coding","chr1:55971283-55983307:-","gi|564325517|ref|XP_006228033.1|",1018,{"v":1e-137,"d":"1.00E-137"},"PREDICTED: tctex1 domain-containing protein 3 isoform X1 [Rattus norvegicus]","gi|672034469|ref|XM_006227971.2|",756,0,"PREDICTED: Rattus norvegicus t-complex-associated testis expressed 3 (Tcte3), transcript variant X1, mRNA","P11985",355,{"v":4e-123,"d":"4.00E-123"},"Tctex1 domain-containing protein 3",".",".",".",".","pfam03645","Tctex-1","Tctex-1 family. Tctex-1 is a dynein light chain. It has been shown that Tctex-1 can bind to the cytoplasmic tail of rhodopsin. C-terminal rhodopsin mutations responsible for retinitis pigmentosa inhibit this interaction.","GO:0007018|microtubule-based movement;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005868|cytoplasmic dynein complex;GO:0019898|extrinsic component of membrane;GO:0036126|sperm flagellum;","GO:0045505|dynein intermediate chain binding;","K25419","DYNLT2, TCTE3; dynein light chain Tctex-type 2"]
["ENSRNOG00000016417",4,0.336541075,16,1.029287011,0.32696524,-1.612790825,0.024712852,0.014172917,"down","yes","ENSRNOG00000016417","protein_coding","chr18:474716-615539:+","gi|564320317|ref|XP_006222562.1|",2500,0,"PREDICTED: zinc finger protein 709 isoform X1 [Rattus norvegicus]","gi|672030392|ref|XM_006222501.2|",1260,0,"PREDICTED: Rattus norvegicus similar to zinc finger protein 124 (RGD1565635), transcript variant X3, mRNA","Q8N972",469,{"v":1E-156,"d":"1.00E-156"},"Zinc finger protein 709",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;",".","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0046872|metal ion binding;",".","."]
["ENSRNOG00000066478",4,0.336541075,16,1.029287011,0.32696524,-1.612790825,0.024712852,0.014172917,"down","yes","ENSRNOG00000066478","lncRNA","chr7:111383555-111403144:+","gi|884912773|ref|XP_013007310.1|",409,{"v":6e-56,"d":"6.00E-56"},"PREDICTED: LOW QUALITY PROTEIN: endogenous retrovirus group K member 113 Pol protein-like [Cavia porcellus]","gi|672022133|ref|XR_348114.2|",1440,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102547313 (LOC102547313), ncRNA",".",".",".",".",".",".",".",".","pfam00692","dUTPase","dUTPase. dUTPase hydrolyses dUTP to dUMP and pyrophosphate.",".",".",".",".","."]
["ENSRNOG00000039207",12,1.009623224,32,2.058574022,0.49044786,-1.027828325,0.025085708,0.014374639,"down","yes","Ccdc71l","protein_coding","chr6:48960191-48960841:+","gi|564355694|ref|XP_003750189.2|",541,{"v":6E-65,"d":"6.00E-65"},"PREDICTED: coiled-coil domain-containing protein 71L isoform X2 [Rattus norvegicus]","gi|672055967|ref|XM_003750141.3|",651,0,"PREDICTED: Rattus norvegicus coiled-coil domain containing 71-like (Ccdc71l), transcript variant X2, mRNA","Q8N9Z2",140,{"v":3e-39,"d":"3.00E-39"},"Coiled-coil domain-containing protein 71L",".",".",".",".","pfam15374","CCDC71L","Coiled-coil domain-containing protein 71L. The protein family, Coiled-coil domain-containing protein 71L, is a domain of unknown function, which is found in eukaryotes.",".",".",".",".","."]
["ENSRNOG00000050714",11,0.925487955,30,1.929913146,0.479549019,-1.060249802,0.026092641,0.014901449,"down","yes","Islr2","protein_coding","chr8:58608709-58614650:-","gi|238859603|ref|NP_001155007.1|",3225,0,"immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform a [Mus musculus]","gi|672062370|ref|XM_008766373.1|",3215,0,"PREDICTED: Rattus norvegicus immunoglobulin superfamily containing leucine-rich repeat protein 2-like (LOC100910729), transcript variant X7, mRNA","Q5RKR3",1203,0,"Immunoglobulin superfamily containing leucine-rich repeat protein 2",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.","GO:0045773|positive regulation of axon extension;","GO:0009986|cell surface;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000014975",5,0.420676343,18,1.157947887,0.363294711,-1.460787732,0.026748145,0.015234261,"down","yes","Zfp483","protein_coding","chr5:73763179-73776223:+","gi|19173796|ref|NP_596913.1|",3738,0,"zinc finger protein 483 [Rattus norvegicus]","gi|19173795|ref|NM_133422.1|",2691,0,"Rattus norvegicus zinc finger protein 483 (Zfp483), mRNA","Q8TF39",739,0,"Zinc finger protein 483",".",".",".",".","pfam02023","SCAN","SCAN domain. The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerization.","GO:0006357|regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0046872|metal ion binding;","K09229","ZKSCAN; KRAB and SCAN domains-containing zinc finger protein"]
["ENSRNOG00000020443",5,0.420676343,18,1.157947887,0.363294711,-1.460787732,0.026748145,0.015234261,"down","yes","Tsks","protein_coding","chr1:95414157-95441662:+","gi|564327991|ref|XP_006229079.1|",1932,0,"PREDICTED: testis-specific serine kinase substrate isoform X4 [Rattus norvegicus]","gi|672036344|ref|XM_006229017.2|",1586,0,"PREDICTED: Rattus norvegicus testis-specific serine kinase substrate (Tsks), transcript variant X4, mRNA","P60531",740,0,"Testis-specific serine kinase substrate",".",".",".",".","pfam15358","TSKS","Testis-specific serine kinase substrate. TSKS, testis-specific serine kinase substrate, is expressed in the testis and is downregulated in cancerous testicular tissue, in comparison with adjacent normal tissue. TSKS expression is very low to undetectable in seminoma, teratocarcinoma, embryonal, and Leydig cell tumors, while high in testicular tissue adjacent to tumors which contain pre-malignant carcinoma in situ. Recently it has been shown in human testis to be localized to the equatorial segment of ejaculated human sperm. The finding of a TSKS family member in mature sperm suggests that this family of kinases might play a role in sperm function. TSKS is localized during spermiogenesis to the centrioles of post-meiotic spermatids, where it reaches its greatest concentration during the period of flagellogenesis.",".","GO:0005737|cytoplasm;GO:0005814|centriole;","GO:0019901|protein kinase binding;","K16492","TSKS; testis-specific serine kinase substrate"]
["ENSRNOG00000030318",5,0.420676343,18,1.157947887,0.363294711,-1.460787732,0.026748145,0.015234261,"down","yes","Gpr83","protein_coding","chr8:11693540-11704028:+","gi|17939358|ref|NP_536336.1|",1979,0,"probable G-protein coupled receptor 83 precursor [Rattus norvegicus]","gi|17939357|ref|NM_080411.1|",3565,0,"Rattus norvegicus G protein-coupled receptor 83 (Gpr83), mRNA","P30731",745,0,"Probable G-protein coupled receptor 83",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007218|neuropeptide signaling pathway;GO:0051384|response to glucocorticoid;","GO:0005887|integral component of plasma membrane;GO:0005929|cilium;GO:0097730|non-motile cilium;","GO:0004983|neuropeptide Y receptor activity;GO:0008188|neuropeptide receptor activity;","K04210","GPR83, GPR72; G protein-coupled receptor 83"]
["ENSRNOG00000063848",5,0.420676343,18,1.157947887,0.363294711,-1.460787732,0.026748145,0.015234261,"down","yes","ENSRNOG00000063848","protein_coding","chr9:74231751-74237923:-","gi|672027568|ref|XP_008762237.1|",1460,0,"PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC102547825 isoform X1, partial [Rattus norvegicus]","gi|388240416|dbj|AP012456.1|",2704,0,"Rattus norvegicus DNA, BAC clone: RNB1-385K15, strain: F344/Stm, complete sequence","P03355",439,0,"Gag-Pol polyprotein",".",".",".",".","pfam02093","Gag_p30","Gag P30 core shell protein. According to Swiss-Prot annotation this protein is the viral core shell protein. P30 is essential for viral assembly.",".",".",".",".","."]
["ENSRNOG00000070368",5,0.420676343,18,1.157947887,0.363294711,-1.460787732,0.026748145,0.015234261,"down","yes","Stx19","protein_coding","chr11:171395-179191:+","gi|157822609|ref|NP_001102930.1|",1411,0,"syntaxin-19 [Rattus norvegicus]","gi|157822608|ref|NM_001109460.1|",1180,0,"Rattus norvegicus syntaxin 19 (Stx19), mRNA","Q8R1Q0",511,{"v":1E-169,"d":"1.00E-169"},"Syntaxin-19",".",".",".",".","pfam05739","SNARE","SNARE domain. Most if not all vesicular membrane fusion events in eukaryotic cells are believed to be mediated by a conserved fusion machinery, the SNARE [soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) receptors] machinery. The SNARE domain is thought to act as a protein-protein interaction module in the assembly of a SNARE protein complex.",".",".",".",".","."]
["ENSRNOG00000007605",10,0.841352686,28,1.801252269,0.4670932,-1.098217652,0.026983222,0.015342469,"down","yes","AABR07052430.1","protein_coding","chr3:51559683-51560524:-","gi|795271913|ref|XP_011857417.1|",1211,{"v":2E-165,"d":"2.00E-165"},"PREDICTED: 40S ribosomal protein S3 isoform X1 [Mandrillus leucophaeus]","gi|388240401|dbj|AP012441.1|",842,0,"Rattus norvegicus DNA, BAC clone: RNB1-108K09, strain: F344/Stm, complete sequence","P62909",468,{"v":2e-166,"d":"2.00E-166"},"40S ribosomal protein S3","SPBC16G5.14c",307,{"v":2e-103,"d":"2.00E-103"},"COG0092","pfam00189","Ribosomal_S3_C","Ribosomal protein S3, C-terminal domain. This family contains a central domain pfam00013, hence the amino and carboxyl terminal domains are stored separately. This is a minimal carboxyl-terminal domain. Some are much longer.","GO:0006281|DNA repair;GO:0006412|translation;GO:0006417|regulation of translation;GO:0006915|apoptotic process;GO:0051301|cell division;","GO:0005743|mitochondrial inner membrane;GO:0005819|spindle;","GO:0003677|DNA binding;GO:0003723|RNA binding;GO:0140078|class I DNA-(apurinic or apyrimidinic site) endonuclease activity;",".","."]
["ENSRNOG00000016381",10,0.841352686,28,1.801252269,0.4670932,-1.098217652,0.026983222,0.015342469,"down","yes","Ust","protein_coding","chr1:2669592-2962044:-","gi|157823625|ref|NP_001101928.1|",1919,0,"uronyl 2-sulfotransferase [Rattus norvegicus]","gi|157823624|ref|NM_001108458.1|",1719,0,"Rattus norvegicus uronyl-2-sulfotransferase (Ust), mRNA","Q8BUB6",731,0,"Uronyl 2-sulfotransferase",".",".",".",".","pfam03567","Sulfotransfer_2","Sulfotransferase family. This family includes a variety of sulfotransferase enzymes. Chondroitin 6-sulfotransferase catalyses the transfer of sulfate to position 6 of the N-acetylgalactosamine residue of chondroitin. This family also includes Heparan sulfate 2-O-sulfotransferase (HS2ST) and Heparan sulfate 6-sulfotransferase (HS6ST). Heparan sulfate (HS) is a co-receptor for a number of growth factors, morphogens, and adhesion proteins. HS biosynthetic modifications may determine the strength and outcome of HS-ligand interactions. Mice that lack HS2ST undergo developmental failure only after midgestation,the most dramatic effect being the complete failure of kidney development. Heparan sulphate 6- O -sulfotransferase (HS6ST) catalyses the transfer of sulphate from adenosine 3'-phosphate, 5'-phosphosulphate to the 6th position of the N -sulphoglucosamine residue in heparan sulphate.","GO:0030010|establishment of cell polarity;GO:0050770|regulation of axonogenesis;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0008146|sulfotransferase activity;","K03193","UST; dermatan/chondrotin sulfate uronyl 2-O-sulfotransferase UST [EC:2.8.2.-]"]
["ENSRNOG00000070972",10,0.841352686,28,1.801252269,0.4670932,-1.098217652,0.026983222,0.015342469,"down","yes","ENSRNOG00000070972","protein_coding","chr15:4625982-4688858:-","gi|564385445|ref|XP_006251744.1|",1093,{"v":3e-145,"d":"3.00E-145"},"PREDICTED: uncharacterized protein LOC102547093 isoform X2 [Rattus norvegicus]","gi|672028263|ref|XM_006221886.2|",1096,0,"PREDICTED: Rattus norvegicus disks large homolog 5-like (LOC102547212), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam04822","Takusan","Takusan. This domain is named takusan, which is a Japanese word meaning 'many'. Members of this family regulate synaptic activity.",".",".",".",".","."]
["ENSRNOG00000007247",2,0.168270537,11,0.70763482,0.237792902,-2.072222444,0.027137053,0.015409018,"down","yes","A2ml1","protein_coding","chr4:161814708-161857343:-","gi|293347095|ref|XP_001066684.2|",7732,0,"PREDICTED: ovostatin homolog 2 isoform X1 [Rattus norvegicus]","gi|672018783|ref|XM_001066684.4|",4695,0,"PREDICTED: Rattus norvegicus alpha-2-macroglobulin-like 1 (A2ml1), transcript variant X1, mRNA","Q3UU35",2573,0,"Ovostatin homolog","TM0984",65.9,1e-09,"COG2373","pfam07678","A2M_comp","A-macroglobulin complement component. This family includes the complement components region of the alpha-2-macroglobulin family.","GO:0010951|negative regulation of endopeptidase activity;","GO:0005615|extracellular space;","GO:0004867|serine-type endopeptidase inhibitor activity;","K23593","A2ML; alpha-2-macroglobulin-like protein"]
["ENSRNOG00000007680",2,0.168270537,11,0.70763482,0.237792902,-2.072222444,0.027137053,0.015409018,"down","yes","Fhl5","protein_coding","chr5:38907946-38956552:-","gi|61556917|ref|NP_001013106.1|",1507,0,"four and a half LIM domains protein 5 [Rattus norvegicus]","gi|61556916|ref|NM_001013088.1|",938,0,"Rattus norvegicus four and a half LIM domains 5 (Fhl5), mRNA","Q6AXT1",585,0,"Four and a half LIM domains protein 5",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.","GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;GO:0030018|Z disc;","GO:0003712|transcription coregulator activity;GO:0003713|transcription coactivator activity;GO:0046872|metal ion binding;","K24415","FHL5, ACT; four and a half LIM domains protein 5"]
["ENSRNOG00000020686",2,0.168270537,11,0.70763482,0.237792902,-2.072222444,0.027137053,0.015409018,"down","yes","Dkkl1","protein_coding","chr1:95694010-95699259:-","gi|157820629|ref|NP_001102615.1|",1027,{"v":1E-136,"d":"1.00E-136"},"dickkopf-like protein 1 precursor [Rattus norvegicus]","gi|157820628|ref|NM_001109145.1|",1140,0,"Rattus norvegicus dickkopf like acrosomal protein 1 (Dkkl1), mRNA","Q9QZL9",354,{"v":4e-120,"d":"4.00E-120"},"Dickkopf-like protein 1",".",".",".",".","pfam00223","PsaA_PsaB","Photosystem I psaA/psaB protein.","GO:0007341|penetration of zona pellucida;GO:0043065|positive regulation of apoptotic process;GO:0045600|positive regulation of fat cell differentiation;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:2000225|negative regulation of testosterone biosynthetic process;GO:2000272|negative regulation of signaling receptor activity;","GO:0001669|acrosomal vesicle;GO:0005615|extracellular space;","GO:0039706|co-receptor binding;GO:0048019|receptor antagonist activity;",".","."]
["ENSRNOG00000036631",2,0.168270537,11,0.70763482,0.237792902,-2.072222444,0.027137053,0.015409018,"down","yes","Ptgdr2","protein_coding","chr1:207587917-207589213:+","gi|58865714|ref|NP_001012070.1|",1729,0,"prostaglandin D2 receptor 2 [Rattus norvegicus]","gi|672039722|ref|XM_008760231.1|",1297,0,"PREDICTED: Rattus norvegicus prostaglandin D2 receptor 2 (Ptgdr2), transcript variant X2, mRNA","Q6XKD3",670,0,"Prostaglandin D2 receptor 2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0006935|chemotaxis;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007193|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007218|neuropeptide signaling pathway;GO:0019722|calcium-mediated signaling;GO:0045745|positive regulation of G protein-coupled receptor signaling pathway;GO:2000255|negative regulation of male germ cell proliferation;","GO:0005887|integral component of plasma membrane;GO:0043005|neuron projection;","GO:0001785|prostaglandin J receptor activity;GO:0004930|G protein-coupled receptor activity;GO:0004956|prostaglandin D receptor activity;GO:0004958|prostaglandin F receptor activity;GO:0042277|peptide binding;GO:0042923|neuropeptide binding;","K06715","PTGDR2, GPR44, CD294; prostaglandin D2 receptor 2"]
["ENSRNOG00000046852",2,0.168270537,11,0.70763482,0.237792902,-2.072222444,0.027137053,0.015409018,"down","yes","B3gat2","protein_coding","chr9:26167174-26250153:+","gi|12018284|ref|NP_072131.1|",1727,0,"galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 precursor [Rattus norvegicus]","gi|451958053|ref|NM_022609.2|",1993,0,"Rattus norvegicus beta-1,3-glucuronyltransferase 2 (B3gat2), mRNA","Q9Z137",669,0,"Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2",".",".",".",".","pfam03360","Glyco_transf_43","Glycosyltransferase family 43.","GO:0005975|carbohydrate metabolic process;GO:0006486|protein glycosylation;GO:0016051|carbohydrate biosynthetic process;GO:0050650|chondroitin sulfate proteoglycan biosynthetic process;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0015018|galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity;GO:0046872|metal ion binding;","K10157","B3GAT2; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 [EC:2.4.1.135]"]
["ENSRNOG00000049527",2,0.168270537,11,0.70763482,0.237792902,-2.072222444,0.027137053,0.015409018,"down","yes","AC109707.1","protein_coding","chr14:43128814-43130403:+","gi|821399055|ref|XP_004274506.2|",360,{"v":2e-40,"d":"2.00E-40"},"PREDICTED: LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1 [Orcinus orca]","gi|672027902|ref|XR_146600.3|",199,{"v":2e-98,"d":"2.00E-98"},"PREDICTED: Rattus norvegicus similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) (HDP) (LOC684970), misc_RNA","A5A6H4",138,{"v":4e-39,"d":"4.00E-39"},"Heterogeneous nuclear ribonucleoprotein A1",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.",".",".",".",".","."]
["ENSRNOG00000054889",2,0.168270537,11,0.70763482,0.237792902,-2.072222444,0.027137053,0.015409018,"down","yes","Wdr72","protein_coding","chr8:74838318-75018229:+","gi|208973290|ref|NP_001129191.1|",5378,0,"WD repeat-containing protein 72 [Rattus norvegicus]","gi|208973289|ref|NM_001135719.1|",3133,0,"Rattus norvegicus WD repeat domain 72 (Wdr72), mRNA","D3YYM4",1946,0,"WD repeat-containing protein 72",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.","GO:0008150|biological_process;GO:0022617|extracellular matrix disassembly;GO:0070166|enamel mineralization;GO:0072659|protein localization to plasma membrane;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005768|endosome;","GO:0003674|molecular_function;","K24753","WDR72; WD repeat-containing protein 72"]
["ENSRNOG00000064500",2,0.168270537,11,0.70763482,0.237792902,-2.072222444,0.027137053,0.015409018,"down","yes","ENSRNOG00000064500","protein_coding","chr1:2238538-2239174:-","gi|149052078|gb|EDM03895.1|",340,{"v":4e-39,"d":"4.00E-39"},"similar to HN1-like protein, isoform CRA_b [Rattus norvegicus]","gi|56090505|ref|NG_004746.1|",231,{"v":2E-116,"d":"2.00E-116"},"Rattus norvegicus HN1-like pseudogene (LOC493584) on chromosome 1","Q5BK20",135,{"v":7e-40,"d":"7.00E-40"},"Jupiter microtubule associated homolog 2",".",".",".",".","pfam07218","RAP1","Rhoptry-associated protein 1 (RAP-1). This family consists of several rhoptry-associated protein 1 (RAP-1) sequences which appear to be specific to Plasmodium falciparum.",".",".",".",".","."]
["ENSRNOG00000069443",2,0.168270537,11,0.70763482,0.237792902,-2.072222444,0.027137053,0.015409018,"down","yes","ENSRNOG00000069443","protein_coding","chr8:89496635-89497752:-","gi|146762521|gb|ABQ45361.1|",395,{"v":4e-46,"d":"4.00E-46"},"synaptotagmin-binding cytoplasmic RNA-interacting protein [Marmota monax]","gi|672062794|ref|XM_008766471.1|",225,{"v":6e-113,"d":"6.00E-113"},"PREDICTED: Rattus norvegicus uncharacterized LOC100910069 (LOC100910069), mRNA","Q7TMK9",157,{"v":4e-45,"d":"4.00E-45"},"Heterogeneous nuclear ribonucleoprotein Q",".",".",".",".","pfam01451","LMWPc","Low molecular weight phosphotyrosine protein phosphatase.",".",".",".",".","."]
["ENSRNOG00000070557",2,0.168270537,11,0.70763482,0.237792902,-2.072222444,0.027137053,0.015409018,"down","yes","ENSRNOG00000070557","snoRNA","chr10:15284997-15285098:-",".",".",".",".","gi|31376410|gb|AC096051.7|",102,{"v":4e-45,"d":"4.00E-45"},"Rattus norvegicus 10 BAC CH230-21G1 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam00007","Cys_knot","Cystine-knot domain. The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.",".",".",".",".","."]
["ENSRNOG00000004353",9,0.757217418,26,1.672591393,0.452721102,-1.143305542,0.02769788,0.015686571,"down","yes","Ppfia2","protein_coding","chr7:41765575-42239599:+","gi|568967826|ref|XP_006513838.1|",5828,0,"PREDICTED: liprin-alpha-2 isoform X2 [Mus musculus]","gi|672058579|ref|XM_008765329.1|",4438,0,"PREDICTED: Rattus norvegicus protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 (Ppfia2), transcript variant X2, mRNA","O75334",2229,0,"Liprin-alpha-2",".",".",".",".","pfam13868","Trichoplein","tumor suppressor, Mitostatin. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs).","GO:0008150|biological_process;GO:0050808|synapse organization;GO:0060998|regulation of dendritic spine development;GO:0061001|regulation of dendritic spine morphogenesis;GO:0099172|presynapse organization;GO:0099519|dense core granule cytoskeletal transport;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0005575|cellular_component;GO:0030424|axon;GO:0043197|dendritic spine;GO:0045202|synapse;GO:0048786|presynaptic active zone;GO:0098978|glutamatergic synapse;GO:0099523|presynaptic cytosol;","GO:0003674|molecular_function;GO:0044877|protein-containing complex binding;GO:0099181|structural constituent of presynapse;",".","."]
["ENSRNOG00000049047",6,0.504811612,20,1.286608764,0.392358288,-1.349756419,0.027847133,0.015759625,"down","yes","Rpl38","protein_coding","chr16:10182742-10182954:-","gi|327358533|gb|AEA51113.1|",277,{"v":7e-30,"d":"7.00E-30"},"60S ribosomal protein L38, partial [Oryzias melastigma]","gi|672079841|ref|XR_596381.1|",213,{"v":2e-106,"d":"2.00E-106"},"PREDICTED: Rattus norvegicus ribosomal protein L38, pseudogene 3 (Rpl38-ps3), misc_RNA","P63174",97.1,{"v":3e-26,"d":"3.00E-26"},"60S ribosomal protein L38",".",".",".",".","pfam01781","Ribosomal_L38e","Ribosomal L38e protein family.",".",".",".",".","."]
["ENSRNOG00000067167",6,0.504811612,20,1.286608764,0.392358288,-1.349756419,0.027847133,0.015759625,"down","yes","Tmem263","protein_coding","chr7:18610149-18628534:-","gi|859763328|ref|XP_012907010.1|",461,{"v":7e-50,"d":"7.00E-50"},"PREDICTED: transmembrane protein 263 isoform X1 [Mustela putorius furo]","gi|672058247|ref|XM_008765244.1|",2574,0,"PREDICTED: Rattus norvegicus transmembrane protein 263 (Tmem263), transcript variant X2, mRNA","Q9DAM7",182,{"v":3E-51,"d":"3.00E-51"},"Transmembrane protein 263",".",".",".",".","pfam15475","UPF0444","Transmembrane protein C12orf23, UPF0444. This family of proteins is found in eukaryotes. Proteins in this family are typically between 94 and 119 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000018268",8,0.673082149,24,1.543930516,0.435953653,-1.197753326,0.02815697,0.015901916,"down","yes","Hhip","protein_coding","chr19:27863213-27952528:+","gi|300797038|ref|NP_001178746.1|",3583,0,"hedgehog-interacting protein precursor [Rattus norvegicus]","gi|300797037|ref|NM_001191817.1|",2542,0,"Rattus norvegicus Hedgehog-interacting protein (Hhip), mRNA","Q7TN16",1331,0,"Hedgehog-interacting protein","SMb20301",63.5,1e-09,"COG2133","pfam03024","Folate_rec","Folate receptor family. This family includes the folate receptor which binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. These proteins are attached to the membrane by a GPI-anchor. The proteins contain 16 conserved cysteines that form eight disulphide bridges.","GO:0007165|signal transduction;GO:0007405|neuroblast proliferation;GO:0009887|animal organ morphogenesis;GO:0009953|dorsal/ventral pattern formation;GO:0009968|negative regulation of signal transduction;GO:0040036|regulation of fibroblast growth factor receptor signaling pathway;GO:0043066|negative regulation of apoptotic process;GO:0045879|negative regulation of smoothened signaling pathway;GO:0048705|skeletal system morphogenesis;GO:0060441|epithelial tube branching involved in lung morphogenesis;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;","GO:0003674|molecular_function;GO:0003824|catalytic activity;GO:0008270|zinc ion binding;GO:0097108|hedgehog family protein binding;","K06231","HHIP; hedgehog interacting protein"]
["ENSRNOG00000054954",8,0.673082149,24,1.543930516,0.435953653,-1.197753326,0.02815697,0.015901916,"down","yes","Lilrb2","protein_coding","chr1:65326832-65334679:+","gi|347921954|ref|NP_113901.2|",2989,0,"neutrophil immunoglobulin-like receptor 1 [Rattus norvegicus]","gi|13928999|ref|NM_031713.1|",2630,0,"Rattus norvegicus paired Ig-like receptor B (Pirb), mRNA","D3ZQX2",1112,0,"Neutrophil immunoglobulin-like receptor 1",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0002578|negative regulation of antigen processing and presentation;GO:0002645|positive regulation of tolerance induction;GO:0002666|positive regulation of T cell tolerance induction;GO:0002767|immune response-inhibiting cell surface receptor signaling pathway;GO:0002774|Fc receptor mediated inhibitory signaling pathway;GO:0007165|signal transduction;GO:0019221|cytokine-mediated signaling pathway;GO:0034113|heterotypic cell-cell adhesion;GO:0042102|positive regulation of T cell proliferation;GO:0042130|negative regulation of T cell proliferation;GO:0045591|positive regulation of regulatory T cell differentiation;GO:0051926|negative regulation of calcium ion transport;GO:0071222|cellular response to lipopolysaccharide;GO:0140105|interleukin-10-mediated signaling pathway;GO:2000524|negative regulation of T cell costimulation;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0001540|amyloid-beta binding;GO:0008157|protein phosphatase 1 binding;GO:0023025|MHC class Ib protein complex binding;GO:0023029|MHC class Ib protein binding;GO:0032396|inhibitory MHC class I receptor activity;GO:0042288|MHC class I protein binding;GO:0042803|protein homodimerization activity;GO:0044877|protein-containing complex binding;GO:0050839|cell adhesion molecule binding;","K06512","LILR, CD85; leukocyte immunoglobulin-like receptor"]
["ENSRNOG00000070152",8,0.673082149,24,1.543930516,0.435953653,-1.197753326,0.02815697,0.015901916,"down","yes","ENSRNOG00000070152","lncRNA","chr7:69474236-69535169:+",".",".",".",".","gi|672059097|ref|XR_593506.1|",1314,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102550687 (LOC102550687), transcript variant X2, ncRNA",".",".",".",".",".",".",".",".","pfam04427","Brix","Brix domain.",".",".",".",".","."]
["ENSRNOG00000008467",7,0.588946881,22,1.41526964,0.416137578,-1.264867522,0.028254049,0.015948471,"down","yes","Agbl2","protein_coding","chr3:76764238-76800214:+","gi|672017426|ref|XP_008773752.1|",4157,0,"PREDICTED: cytosolic carboxypeptidase 2 isoform X1 [Rattus norvegicus]","gi|672046238|ref|XM_008762015.1|",2895,0,"PREDICTED: Rattus norvegicus ATP/GTP binding protein-like 2 (Agbl2), transcript variant X2, mRNA","Q8CDK2",1484,0,"Cytosolic carboxypeptidase 2","NMA1274",96.7,{"v":3e-20,"d":"3.00E-20"},"COG2866","pfam00246","Peptidase_M14","Zinc carboxypeptidase.","GO:0006508|proteolysis;GO:0035610|protein side chain deglutamylation;","GO:0005814|centriole;GO:0005829|cytosol;GO:0036064|ciliary basal body;","GO:0004181|metallocarboxypeptidase activity;GO:0008270|zinc ion binding;","K23437","AGBL2_3, CCP2_3; cytosolic carboxypeptidase protein 2/3 [EC:3.4.17.-]"]
["ENSRNOG00000062794",7,0.588946881,22,1.41526964,0.416137578,-1.264867522,0.028254049,0.015948471,"down","yes","Gypa","protein_coding","chr19:27450308-27465822:-","gi|149037943|gb|EDL92303.1|",499,{"v":9e-58,"d":"9.00E-58"},"rCG51636 [Rattus norvegicus]","gi|298904585|emb|FQ225003.1|",1211,0,"Rattus norvegicus TL0AEA55YH08 mRNA sequence","P14220",76.3,{"v":9e-15,"d":"9.00E-15"},"Glycophorin-A",".",".",".",".","pfam01102","Glycophorin_A","Glycophorin A.",".",".",".",".","."]
["ENSRNOG00000069312",7,0.588946881,22,1.41526964,0.416137578,-1.264867522,0.028254049,0.015948471,"down","yes","ENSRNOG00000069312","protein_coding","chr9:113936360-113982471:+","gi|148705231|gb|EDL37178.1|",2812,0,"mCG23594 [Mus musculus]","gi|672025761|ref|XM_008775911.1|",1182,0,"PREDICTED: Rattus norvegicus zinc finger protein 120-like (LOC102547688), transcript variant X1, mRNA","Q05481",875,0,"Zinc finger protein 91",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000002372",1,0.084135269,8,0.514643505,0.16348262,-2.612790825,0.030510332,0.017045044,"down","yes","Sgcd","protein_coding","chr10:31280511-31724840:-","gi|198386317|ref|NP_001128298.1|",1440,0,"delta-sarcoglycan isoform b [Rattus norvegicus]","gi|198386316|ref|NM_001134826.1|",1356,0,"Rattus norvegicus sarcoglycan, delta (Sgcd), transcript variant 1, mRNA","P82347",556,0,"Delta-sarcoglycan",".",".",".",".","pfam04790","Sarcoglycan_1","Sarcoglycan complex subunit protein. The dystrophin glycoprotein complex (DGC) is a membrane-spanning complex that links the interior cytoskeleton to the extracellular matrix in muscle. The sarcoglycan complex is a subcomplex within the DGC and is composed of several muscle-specific, transmembrane proteins (alpha-, beta-, gamma-, delta- and zeta-sarcoglycan). The sarcoglycans are asparagine-linked glycosylated proteins with single transmembrane domains. This family contains beta, gamma and delta members.","GO:0003015|heart process;GO:0008150|biological_process;GO:0019722|calcium-mediated signaling;GO:0034629|cellular protein-containing complex localization;GO:0048738|cardiac muscle tissue development;GO:0055013|cardiac muscle cell development;GO:0055074|calcium ion homeostasis;GO:0060047|heart contraction;GO:0060048|cardiac muscle contraction;GO:0060977|coronary vasculature morphogenesis;GO:0086003|cardiac muscle cell contraction;","GO:0005575|cellular_component;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0016010|dystrophin-associated glycoprotein complex;GO:0016011|dystroglycan complex;GO:0016012|sarcoglycan complex;GO:0016021|integral component of membrane;GO:0016529|sarcoplasmic reticulum;GO:0042383|sarcolemma;","GO:0003674|molecular_function;","K12563","SGCD; delta-sarcoglycan"]
["ENSRNOG00000007031",1,0.084135269,8,0.514643505,0.16348262,-2.612790825,0.030510332,0.017045044,"down","yes","Trim9","protein_coding","chr6:88757303-88856542:-","gi|556522611|ref|NP_001273317.1|",4109,0,"E3 ubiquitin-protein ligase TRIM9 isoform f [Mus musculus]","gi|672056250|ref|XM_008764691.1|",3977,0,"PREDICTED: Rattus norvegicus tripartite motif-containing 9 (Trim9), transcript variant X1, mRNA","Q8C7M3",1549,0,"E3 ubiquitin-protein ligase TRIM9",".",".",".",".","pfam00622","SPRY","SPRY domain. SPRY Domain is named from SPla and the RYanodine Receptor. Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.","GO:0016079|synaptic vesicle exocytosis;GO:0016567|protein ubiquitination;GO:0035544|negative regulation of SNARE complex assembly;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045955|negative regulation of calcium ion-dependent exocytosis;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0008021|synaptic vesicle;GO:0030425|dendrite;GO:0099523|presynaptic cytosol;","GO:0000149|SNARE binding;GO:0008270|zinc ion binding;GO:0019904|protein domain specific binding;GO:0042803|protein homodimerization activity;GO:0061630|ubiquitin protein ligase activity;","K10649","TRIM9_67; tripartite motif-containing protein 9/67"]
["ENSRNOG00000013399",1,0.084135269,8,0.514643505,0.16348262,-2.612790825,0.030510332,0.017045044,"down","yes","Minar1","protein_coding","chr8:90137374-90169137:-","gi|109483758|ref|XP_001055454.1|",4844,0,"PREDICTED: UPF0258 protein KIAA1024 homolog [Rattus norvegicus]","gi|672023167|ref|XM_001066296.5|",5648,0,"PREDICTED: Rattus norvegicus similar to UPF0258 protein KIAA1024 (LOC501033), mRNA","Q8K3V7",1819,0,"UPF0258 protein KIAA1024",".",".",".",".","pfam06789","UPF0258","Uncharacterized protein family (UPF0258).","GO:0008285|negative regulation of cell proliferation;GO:0010977|negative regulation of neuron projection development;GO:0016525|negative regulation of angiogenesis;GO:0030308|negative regulation of cell growth;GO:0031397|negative regulation of protein ubiquitination;GO:0032007|negative regulation of TOR signaling;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;",".","K24829","MINAR1; major intrinsically disordered Notch2-binding receptor 1"]
["ENSRNOG00000013658",1,0.084135269,8,0.514643505,0.16348262,-2.612790825,0.030510332,0.017045044,"down","yes","Nefl","protein_coding","chr15:42301916-42305793:+","gi|984126115|ref|XP_015354881.1|",1876,0,"PREDICTED: neurofilament light polypeptide [Marmota marmota marmota]","gi|13929097|ref|NM_031783.1|",2023,0,"Rattus norvegicus neurofilament, light polypeptide (Nefl), mRNA","P19527",720,0,"Neurofilament light polypeptide",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0000226|microtubule cytoskeleton organization;GO:0008089|anterograde axonal transport;GO:0008090|retrograde axonal transport;GO:0009636|response to toxic substance;GO:0010033|response to organic substance;GO:0014012|peripheral nervous system axon regeneration;GO:0019896|axonal transport of mitochondrion;GO:0021510|spinal cord development;GO:0021766|hippocampus development;GO:0021987|cerebral cortex development;GO:0031133|regulation of axon diameter;GO:0033693|neurofilament bundle assembly;GO:0040011|locomotion;GO:0043434|response to peptide hormone;GO:0043524|negative regulation of neuron apoptotic process;GO:0045105|intermediate filament polymerization or depolymerization;GO:0045109|intermediate filament organization;GO:0045110|intermediate filament bundle assembly;GO:0048812|neuron projection morphogenesis;GO:0050772|positive regulation of axonogenesis;GO:0050885|neuromuscular process controlling balance;GO:0051258|protein polymerization;GO:0051412|response to corticosterone;GO:0060052|neurofilament cytoskeleton organization;GO:0060074|synapse maturation;GO:0099185|postsynaptic intermediate filament cytoskeleton organization;GO:1903935|response to sodium arsenite;GO:1903937|response to acrylamide;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005882|intermediate filament;GO:0005883|neurofilament;GO:0030424|axon;GO:0030426|growth cone;GO:0031594|neuromuscular junction;GO:0043005|neuron projection;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098981|cholinergic synapse;GO:0099160|postsynaptic intermediate filament cytoskeleton;GO:0099182|presynaptic intermediate filament cytoskeleton;GO:1904115|axon cytoplasm;","GO:0005200|structural constituent of cytoskeleton;GO:0008022|protein C-terminus binding;GO:0019904|protein domain specific binding;GO:0030674|protein binding, bridging;GO:0042802|identical protein binding;GO:0043274|phospholipase binding;GO:0044877|protein-containing complex binding;GO:0099184|structural constituent of postsynaptic intermediate filament cytoskeleton;","K04572","NEFL, NF-L; neurofilament light polypeptide"]
["ENSRNOG00000019467",1,0.084135269,8,0.514643505,0.16348262,-2.612790825,0.030510332,0.017045044,"down","yes","Fer1l4","protein_coding","chr3:144536099-144571634:-","gi|211971050|ref|NP_001100004.2|",9190,0,"fer-1-like protein 4 [Rattus norvegicus]","gi|211971049|ref|NM_001106534.2|",6098,0,"Rattus norvegicus fer-1-like family member 4 (Fer1l4), mRNA","A3KGK3",3322,0,"Fer-1-like protein 4",".",".",".",".","pfam08151","FerI","FerI (NUC094) domain. This domain is present in proteins of the Ferlin family. It is often located between two C2 domains.","GO:0007009|plasma membrane organization;","GO:0016021|integral component of membrane;","GO:0046872|metal ion binding;",".","."]
["ENSRNOG00000020489",1,0.084135269,8,0.514643505,0.16348262,-2.612790825,0.030510332,0.017045044,"down","yes","Tmem145","protein_coding","chr1:80891927-80901611:+","gi|568946037|ref|XP_006540177.1|",2280,0,"PREDICTED: transmembrane protein 145 isoform X1 [Mus musculus]","gi|755519763|ref|XM_006540114.2|",1630,0,"PREDICTED: Mus musculus transmembrane protein 145 (Tmem145), transcript variant X1, mRNA","Q8C4U2",832,0,"Transmembrane protein 145",".",".",".",".","pfam10192","GpcrRhopsn4","Rhodopsin-like GPCR transmembrane domain. This region of 270 amino acids is the seven transmembrane alpha-helical domains included within five GPCRRHODOPSN4 motifs of a G-protein-coupled-receptor (GPCR) protein, conserved from nematodes to humans. GPCRs are integral membrane receptors whose intracellular actions are mediated by signalling pathways involving G proteins and downstream secondary messengers.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0019236|response to pheromone;","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000027836",1,0.084135269,8,0.514643505,0.16348262,-2.612790825,0.030510332,0.017045044,"down","yes","Kcnmb3","protein_coding","chr2:115253761-115270142:-","gi|157151708|ref|NP_001098030.1|",1185,{"v":8e-158,"d":"8.00E-158"},"calcium-activated potassium channel subunit beta-3 [Rattus norvegicus]","gi|402744437|ref|NM_001104560.2|",1637,0,"Rattus norvegicus potassium calcium-activated channel subfamily M regulatory beta subunit 3 (Kcnmb3), mRNA","A7VL23",461,{"v":3e-159,"d":"3.00E-159"},"Calcium-activated potassium channel subunit beta-3",".",".",".",".","pfam03185","CaKB","Calcium-activated potassium channel, beta subunit.","GO:0001508|action potential;GO:0005513|detection of calcium ion;GO:0006813|potassium ion transport;GO:0019228|neuronal action potential;GO:0071805|potassium ion transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0008076|voltage-gated potassium channel complex;","GO:0015269|calcium-activated potassium channel activity;GO:0015459|potassium channel regulator activity;","K04939","KCNMB3; potassium large conductance calcium-activated channel subfamily M beta member 3"]
["ENSRNOG00000029644",1,0.084135269,8,0.514643505,0.16348262,-2.612790825,0.030510332,0.017045044,"down","yes","Clec2l","protein_coding","chr4:67397873-67414537:+","gi|168229212|ref|NP_001037698.2|",920,{"v":3e-118,"d":"3.00E-118"},"C-type lectin domain family 2 member L [Rattus norvegicus]","gi|108735449|gb|DQ630549.1|",1124,0,"Rattus norvegicus CD69-like protein mRNA, complete cds","Q0ZCA7",358,{"v":1E-119,"d":"1.00E-119"},"C-type lectin domain family 2 member L",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type",".","GO:0016021|integral component of membrane;","GO:0030246|carbohydrate binding;","K22681","CLEC2L; c-type lectin domain family 2 member L"]
["ENSRNOG00000035516",1,0.084135269,8,0.514643505,0.16348262,-2.612790825,0.030510332,0.017045044,"down","yes","Mir132","miRNA","chr10:60023696-60023796:+","gi|635086817|ref|XP_008008006.1|",159,{"v":2E-12,"d":"2.00E-12"},"PREDICTED: transcription initiation factor TFIID subunit 4-like, partial [Chlorocebus sabaeus]","gi|731442366|ref|NR_129072.1|",101,{"v":1e-44,"d":"1.00E-44"},"Eptesicus fuscus microRNA mir-132 (MIR132), microRNA",".",".",".",".",".",".",".",".","pfam11456","DUF3019","Protein of unknown function (DUF3019). This is a bacterial family of uncharacterized proteins.","GO:0007569|cell aging;GO:0014041|regulation of neuron maturation;GO:0050773|regulation of dendrite development;GO:0060291|long-term synaptic potentiation;GO:0070482|response to oxygen levels;GO:0071241|cellular response to inorganic substance;GO:1904322|cellular response to forskolin;","GO:0014069|postsynaptic density;",".",".","."]
["ENSRNOG00000042391",1,0.084135269,8,0.514643505,0.16348262,-2.612790825,0.030510332,0.017045044,"down","yes","Serpina9","protein_coding","chr6:122918880-122936000:-","gi|157822763|ref|NP_001100224.1|",2015,0,"serpin A9 precursor [Rattus norvegicus]","gi|157822762|ref|NM_001106754.1|",1680,0,"Rattus norvegicus serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9 (Serpina9), mRNA","Q9D7D2",686,0,"Serpin A9","MA2246",142,{"v":4e-36,"d":"4.00E-36"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0010951|negative regulation of endopeptidase activity;","GO:0005615|extracellular space;","GO:0004867|serine-type endopeptidase inhibitor activity;","K04525","SERPINA; serpin A"]
["ENSRNOG00000043061",1,0.084135269,8,0.514643505,0.16348262,-2.612790825,0.030510332,0.017045044,"down","yes","Siah3","protein_coding","chr15:50770871-50834487:+","gi|300798222|ref|NP_001178047.1|",1304,{"v":4e-178,"d":"4.00E-178"},"seven in absentia homolog 3 [Rattus norvegicus]","gi|300798221|ref|NM_001191118.1|",807,0,"Rattus norvegicus siah E3 ubiquitin protein ligase family member 3 (Siah3), mRNA","Q8IW03",437,{"v":2e-152,"d":"2.00E-152"},"Seven in absentia homolog 3",".",".",".",".","pfam03145","Sina","Seven in absentia protein family. The seven in absentia (sina) gene was first identified in Drosophila. The Drosophila Sina protein is essential for the determination of the R7 pathway in photoreceptor cell development: the loss of functional Sina results in the transformation of the R7 precursor cell to a non- neuronal cell type. The Sina protein contains an N-terminal RING finger domain pfam00097. Through this domain, Sina binds E2 ubiquitin-conjugating enzymes (UbcD1) Sina also interacts with Tramtrack (TTK88) via PHYL. Tramtrack is a transcriptional repressor that blocks photoreceptor determination, while PHYL down-regulates the activity of TTK88. In turn, the activity of PHYL requires the activation of the Sevenless receptor tyrosine kinase, a process essential for R7 determination. It is thought that thus Sina targets TTK88 for degradation, therefore promoting the R7 pathway. Murine and human homologues of Sina have also been identified. The human homologue Siah-1 also binds E2 enzymes (UbcH5) and through a series of physical interactions, targets beta-catenin for ubiquitin degradation. Siah-1 expression is enhanced by p53, itself promoted by DNA damage. Thus this pathway links DNA damage to beta-catenin degradation. Sina proteins, therefore, physically interact with a variety of proteins. The N-terminal RING finger domain that binds ubiquitin conjugating enzymes is described in pfam00097, and does not form part of the alignment for this family. The remainder C-terminal part is involved in interactions with other proteins, and is included in this alignment. In addition to the Drosophila protein and mammalian homologues, whose similarity was noted previously, this family also includes putative homologues from Caenorhabditis elegans, Arabidopsis thaliana.","GO:0016567|protein ubiquitination;GO:0031647|regulation of protein stability;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:1903215|negative regulation of protein targeting to mitochondrion;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005739|mitochondrion;","GO:0031624|ubiquitin conjugating enzyme binding;GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;","K22256","SIAH3; seven in absentia homolog 3"]
["ENSRNOG00000057598",1,0.084135269,8,0.514643505,0.16348262,-2.612790825,0.030510332,0.017045044,"down","yes","AABR07032520.4","lncRNA","chr18:67437270-67447910:-",".",".",".",".","gi|672030832|ref|XR_598352.1|",548,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103694241 (LOC103694241), ncRNA",".",".",".",".",".",".",".",".","pfam01560","HCV_NS1","Hepatitis C virus non-structural protein E2/NS1. The hypervariable region of the E2/NS1 region of hepatitis C virus varies greatly between viral isolates. E2 is thought to encode a structurally unconstrained envelope protein.",".",".",".",".","."]
["ENSRNOG00000060407",1,0.084135269,8,0.514643505,0.16348262,-2.612790825,0.030510332,0.017045044,"down","yes","Cacna1i","protein_coding","chr7:111836012-111944688:+","gi|157057194|ref|NP_001037773.2|",8797,0,"voltage-dependent T-type calcium channel subunit alpha-1I [Mus musculus]","gi|113195658|ref|NM_020084.3|",6455,0,"Rattus norvegicus calcium voltage-gated channel subunit alpha1 I (Cacna1i), mRNA","Q9Z0Y8",3347,0,"Voltage-dependent T-type calcium channel subunit alpha-1I","BH1501",87,{"v":4e-17,"d":"4.00E-17"},"COG1226","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0006816|calcium ion transport;GO:0019228|neuronal action potential;GO:0030317|flagellated sperm motility;GO:0030431|sleep;GO:0034765|regulation of ion transmembrane transport;GO:0035725|sodium ion transmembrane transport;GO:0042391|regulation of membrane potential;GO:0045956|positive regulation of calcium ion-dependent exocytosis;GO:0060402|calcium ion transport into cytosol;GO:0070509|calcium ion import;GO:0070588|calcium ion transmembrane transport;GO:0086010|membrane depolarization during action potential;","GO:0001518|voltage-gated sodium channel complex;GO:0005891|voltage-gated calcium channel complex;GO:0043005|neuron projection;","GO:0005248|voltage-gated sodium channel activity;GO:0008332|low voltage-gated calcium channel activity;","K04856","CACNA1I, CAV3.3; voltage-dependent calcium channel T type alpha-1I"]
["ENSRNOG00000063006",1,0.084135269,8,0.514643505,0.16348262,-2.612790825,0.030510332,0.017045044,"down","yes","ENSRNOG00000063006","lncRNA","chr2:182733666-182736399:+",".",".",".",".","gi|672043391|ref|XM_006232858.2|",280,{"v":2e-143,"d":"2.00E-143"},"PREDICTED: Rattus norvegicus sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C (Sema6c), transcript variant X8, mRNA",".",".",".",".",".",".",".",".","pfam05772","NinB","NinB protein. The ninR region of phage lambda contains two recombination genes, orf (ninB) and rap (ninG), that have roles when the RecF and RecBCD recombination pathways of Escherichia coli, respectively, operate on phage lambda.",".",".",".",".","."]
["ENSRNOG00000065831",1,0.084135269,8,0.514643505,0.16348262,-2.612790825,0.030510332,0.017045044,"down","yes","Olr162","protein_coding","chr1:158954795-158958503:+","gi|47576529|ref|NP_001000950.1|",1430,0,"olfactory receptor Olr162 [Rattus norvegicus]","gi|90855788|gb|AC128039.4|",1753,0,"Rattus norvegicus BAC CH230-394A24 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q8NGI1",442,{"v":5e-148,"d":"5.00E-148"},"Putative olfactory receptor 56B2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.",".",".",".",".","."]
["ENSRNOG00000065847",1,0.084135269,8,0.514643505,0.16348262,-2.612790825,0.030510332,0.017045044,"down","yes","ENSRNOG00000065847","protein_coding","chr3:138544658-138557896:-","gi|564343505|ref|XP_006235264.1|",331,{"v":2e-34,"d":"2.00E-34"},"PREDICTED: zinc finger protein 120-like [Rattus norvegicus]","gi|672047696|ref|XM_006235202.2|",280,{"v":8e-143,"d":"8.00E-143"},"PREDICTED: Rattus norvegicus zinc finger protein 120-like (LOC102555578), mRNA","Q8BZW4",118,{"v":5e-28,"d":"5.00E-28"},"Zinc finger protein 120",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000066676",1,0.084135269,8,0.514643505,0.16348262,-2.612790825,0.030510332,0.017045044,"down","yes","ENSRNOG00000066676","lncRNA","chr4:11773595-11783462:+","gi|149036607|gb|EDL91225.1|",133,{"v":4e-11,"d":"4.00E-11"},"rCG56442 [Rattus norvegicus]","gi|644988607|tpe|HG979546.1|",123,{"v":1e-55,"d":"1.00E-55"},"TPA: Mus musculus long non-coding RNA OTTMUST00000120169.1 (RP23-443N7.2 gene), lincRNA",".",".",".",".",".",".",".",".","pfam12449","DUF3684","Protein of unknown function (DUF3684). This domain family is found in eukaryotes, and is typically between 1072 and 1090 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000067408",1,0.084135269,8,0.514643505,0.16348262,-2.612790825,0.030510332,0.017045044,"down","yes","ENSRNOG00000067408","lncRNA","chr8:34684180-34715465:+","gi|111813|pir||S21346",152,4e-08,"probable pol polyprotein-related protein 2 - rat","gi|14389324|gb|AC087775.2|",248,{"v":1e-124,"d":"1.00E-124"},"Rattus norvegicus strain Brown Norway clone RP31-464J4, complete sequence","P11369",55.8,3e-06,"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam07302","AroM","AroM protein. This family consists of several bacterial and archaeal AroM proteins. In Escherichia coli the aroM gene is cotranscribed with aroL. The function of this family is unknown.",".",".",".",".","."]
["ENSRNOG00000068282",1,0.084135269,8,0.514643505,0.16348262,-2.612790825,0.030510332,0.017045044,"down","yes","U6","snRNA","chr4:146200474-146200580:+","gi|965792038|ref|XP_014963564.1|",128,2e-07,"PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC106992171 [Ovis aries musimon]","gi|937346585|ref|NG_044010.1|",59,{"v":4e-21,"d":"4.00E-21"},"Homo sapiens RNA, U6 small nuclear 73, pseudogene (RNU6-73P) on chromosome 13",".",".",".",".",".",".",".",".","pfam15110","TMEM141","TMEM141 protein family. The function of this family of transmembrane proteins, TMEM141, has not, as yet, been determined. Members of this family remain uncharacterized. TMEM141 protein family is found in eukaryotes. Proteins in this family are typically between 103 and 124 amino acids in length. There are two completely conserved residues (C and W) that may be functionally important.",".",".",".",".","."]
["ENSRNOG00000070364",1,0.084135269,8,0.514643505,0.16348262,-2.612790825,0.030510332,0.017045044,"down","yes","ENSRNOG00000070364","protein_coding","chr5:103899711-103900717:-","gi|589922405|ref|XP_006974113.1|",163,{"v":2e-13,"d":"2.00E-13"},"PREDICTED: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [Peromyscus maniculatus bairdii]","gi|61657153|emb|CR937047.1|",157,{"v":3e-75,"d":"3.00E-75"},"Rattus norvegicus chromosome 5 BAC CH230-510H6, complete sequence","Q4R5J1",46.6,7e-07,"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5",".",".",".",".","pfam01117","Aerolysin","Aerolysin toxin. This family represents the pore forming lobe of aerolysin.",".",".",".",".","."]
["ENSRNOG00000008846",3,0.252405806,13,0.836295696,0.301814068,-1.728268043,0.033473113,0.018540788,"down","yes","Plag1","protein_coding","chr5:16905394-16913647:-","gi|56605712|ref|NP_001008317.1|",2417,0,"zinc finger protein PLAG1 [Rattus norvegicus]","gi|672051913|ref|XM_008763526.1|",3333,0,"PREDICTED: Rattus norvegicus pleiomorphic adenoma gene 1 (Plag1), transcript variant X2, mRNA","Q5U2T6",935,0,"Zinc finger protein PLAG1",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0006351|transcription, DNA-templated;GO:0006355|regulation of transcription, DNA-templated;GO:0008150|biological_process;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0022612|gland morphogenesis;GO:0035264|multicellular organism growth;GO:0035265|organ growth;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0060252|positive regulation of glial cell proliferation;GO:0060736|prostate gland growth;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005813|centrosome;GO:0005829|cytosol;GO:0016607|nuclear speck;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0046872|metal ion binding;","K19484","PLAG1; zinc finger protein PLAG1"]
["ENSRNOG00000008849",3,0.252405806,13,0.836295696,0.301814068,-1.728268043,0.033473113,0.018540788,"down","yes","Guca2a","protein_coding","chr5:133237177-133239018:+","gi|6980994|ref|NP_037250.1|",484,{"v":4e-59,"d":"4.00E-59"},"guanylin precursor [Rattus norvegicus]","gi|6980993|ref|NM_013118.1|",557,0,"Rattus norvegicus guanylate cyclase activator 2A (Guca2a), mRNA","P28902",191,{"v":1e-60,"d":"1.00E-60"},"Guanylin",".",".",".",".","pfam02058","Guanylin","Guanylin precursor.","GO:0031284|positive regulation of guanylate cyclase activity;","GO:0005576|extracellular region;","GO:0030249|guanylate cyclase regulator activity;GO:0030250|guanylate cyclase activator activity;","K25556","GUCA2; guanylate cyclase activator 2"]
["ENSRNOG00000008988",3,0.252405806,13,0.836295696,0.301814068,-1.728268043,0.033473113,0.018540788,"down","yes","Cyp2d2","protein_coding","chr7:113935138-113939209:-","gi|117242|sp|P10634.2|CP2DQ_RAT",2503,0,"RecName: Full=Cytochrome P450 2D26; AltName: Full=CYPIID26; AltName: Full=Cytochrome P450-CMF2; AltName: Full=Cytochrome P450-DB2; AltName: Full=Debrisoquine 4-hydroxylase","gi|6978746|ref|NM_012730.1|",1668,0,"Rattus norvegicus cytochrome P450, family 2, subfamily d, polypeptide 2 (Cyp2d2), mRNA","P10634",973,0,"Cytochrome P450 2D26","alr1450",81.3,{"v":2e-15,"d":"2.00E-15"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0006082|organic acid metabolic process;GO:0006805|xenobiotic metabolic process;GO:0007565|female pregnancy;GO:0009410|response to xenobiotic stimulus;GO:0019369|arachidonic acid metabolic process;GO:0042178|xenobiotic catabolic process;","GO:0005737|cytoplasm;GO:0005789|endoplasmic reticulum membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0004497|monooxygenase activity;GO:0005506|iron ion binding;GO:0008395|steroid hydroxylase activity;GO:0016712|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0020037|heme binding;GO:0070330|aromatase activity;","K07414","CYP2D; cytochrome P450 family 2 subfamily D [EC:1.14.14.1]"]
["ENSRNOG00000053406",3,0.252405806,13,0.836295696,0.301814068,-1.728268043,0.033473113,0.018540788,"down","yes","Gramd1c","protein_coding","chr11:56633227-56718570:+","gi|300797224|ref|NP_001178755.1|",3263,0,"GRAM domain-containing protein 1C [Rattus norvegicus]","gi|755553289|ref|XM_011245853.1|",2087,0,"PREDICTED: Mus musculus GRAM domain containing 1C (Gramd1c), transcript variant X1, mRNA","Q8IYS0",1052,0,"GRAM domain-containing protein 1C",".",".",".",".","pfam02893","GRAM","GRAM domain. The GRAM domain is found in in glucosyltransferases, myotubularins and other putative membrane-associated proteins.","GO:0015918|sterol transport;GO:0071397|cellular response to cholesterol;GO:0120009|intermembrane lipid transfer;","GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0015485|cholesterol binding;GO:0120020|intermembrane cholesterol transfer activity;",".","."]
["ENSRNOG00000063238",3,0.252405806,13,0.836295696,0.301814068,-1.728268043,0.033473113,0.018540788,"down","yes","ENSRNOG00000063238","lncRNA","chr2:209823763-209826790:-",".",".",".",".","gi|672016260|ref|XR_599962.1|",1021,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102555482 (LOC102555482), ncRNA",".",".",".",".",".",".",".",".","pfam10521","DUF2454","Protein of unknown function (DUF2454). A Schizosaccharomyces pombe member of this family is known to interact with Tel2. Tel2 is a component of the TOR complexes.",".",".",".",".","."]
["ENSRNOG00000063556",3,0.252405806,13,0.836295696,0.301814068,-1.728268043,0.033473113,0.018540788,"down","yes","ENSRNOG00000063556","lncRNA","chr9:59008776-59040615:+",".",".",".",".","gi|48427766|gb|AC109807.9|",589,0,"Mus musculus chromosome 1, clone RP23-433B11, complete sequence",".",".",".",".",".",".",".",".","pfam09770","PAT1","Topoisomerase II-associated protein PAT1. Members of this family are necessary for accurate chromosome transmission during cell division.",".",".",".",".","."]
["ENSRNOG00000066622",3,0.252405806,13,0.836295696,0.301814068,-1.728268043,0.033473113,0.018540788,"down","yes","ENSRNOG00000066622","lncRNA","chr7:62784299-62787126:-",".",".",".",".","gi|672021747|ref|XR_601776.1|",302,{"v":2E-155,"d":"2.00E-155"},"PREDICTED: Rattus norvegicus uncharacterized LOC103690358 (LOC103690358), ncRNA",".",".",".",".",".",".",".",".","pfam03188","Cytochrom_B561","Eukaryotic cytochrome b561. Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.",".",".",".",".","."]
["ENSRNOG00000070127",3,0.252405806,13,0.836295696,0.301814068,-1.728268043,0.033473113,0.018540788,"down","yes","ENSRNOG00000070127","lncRNA","chr7:22915213-22917124:+",".",".",".",".","gi|672058466|ref|XR_593368.1|",306,{"v":1e-157,"d":"1.00E-157"},"PREDICTED: Rattus norvegicus uncharacterized LOC102554140 (LOC102554140), transcript variant X2, ncRNA",".",".",".",".",".",".",".",".","pfam10036","RLL","Putative carnitine deficiency-associated protein. This family of proteins conserved from nematodes to humans is of approximately 250 amino acids. It is purported to be carnitine deficiency-associated protein but this could not be confirmed. It carries a characteristic RLL sequence-motif. The function is unknown.",".",".",".",".","."]
["ENSRNOG00000071100",3,0.252405806,13,0.836295696,0.301814068,-1.728268043,0.033473113,0.018540788,"down","yes","ENSRNOG00000071100","protein_coding","chr6:129666394-129667403:-","gi|406855466|pdb|3J1T|A",337,{"v":2e-37,"d":"2.00E-37"},"Chain A, High Affinity Dynein Microtubule Binding Domain - Tubulin Complex","gi|402527|dbj|D13896.1|RATCDHC",200,{"v":6e-99,"d":"6.00E-99"},"Rattus norvegicus mRNA for cytoplasmic dynein heavy chain, complete cds","Q9JHU4",133,{"v":7e-35,"d":"7.00E-35"},"Cytoplasmic dynein 1 heavy chain 1","SPAC1093.06c",76.3,{"v":1e-15,"d":"1.00E-15"},"COG5245","pfam12777","MT","Microtubule-binding stalk of dynein motor. the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.",".",".",".",".","."]
["ENSRNOG00000019751",11,0.925487955,29,1.865582707,0.496085192,-1.011340202,0.035353357,0.019436272,"down","yes","Cyb5r2","protein_coding","chr1:161655864-161664097:-","gi|672038017|ref|XP_008757998.1|",1607,0,"PREDICTED: NADH-cytochrome b5 reductase 2 isoform X2 [Rattus norvegicus]","gi|672038016|ref|XM_008759776.1|",1138,0,"PREDICTED: Rattus norvegicus cytochrome b5 reductase 2 (Cyb5r2), transcript variant X3, mRNA","Q6AY12",563,0,"NADH-cytochrome b5 reductase 2","SPCC970.03",180,{"v":2E-51,"d":"2.00E-51"},"COG0543","pfam00970","FAD_binding_6","Oxidoreductase FAD-binding domain.","GO:0016126|sterol biosynthetic process;","GO:0016020|membrane;","GO:0004128|cytochrome-b5 reductase activity, acting on NAD(P)H;GO:0071949|FAD binding;","K00326","E1.6.2.2; cytochrome-b5 reductase [EC:1.6.2.2]"]
["ENSRNOG00000061731",11,0.925487955,29,1.865582707,0.496085192,-1.011340202,0.035353357,0.019436272,"down","yes","Plxnb3","protein_coding","chrX:151494207-151508674:+","gi|209529650|ref|NP_001129350.1|",9274,0,"plexin-B3 precursor [Rattus norvegicus]","gi|672088967|ref|XM_006229587.2|",6100,0,"PREDICTED: Rattus norvegicus plexin B3 (Plxnb3), transcript variant X3, mRNA","D3ZLH5",3573,0,"Plexin-B3",".",".",".",".","pfam08337","Plexin_cytopl","Plexin cytoplasmic RasGAP domain. This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.","GO:0001938|positive regulation of endothelial cell proliferation;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007162|negative regulation of cell adhesion;GO:0008360|regulation of cell shape;GO:0010593|negative regulation of lamellipodium assembly;GO:0010976|positive regulation of neuron projection development;GO:0030334|regulation of cell migration;GO:0030336|negative regulation of cell migration;GO:0034260|negative regulation of GTPase activity;GO:0043087|regulation of GTPase activity;GO:0050772|positive regulation of axonogenesis;GO:0050918|positive chemotaxis;GO:0060326|cell chemotaxis;GO:0071526|semaphorin-plexin signaling pathway;GO:1902287|semaphorin-plexin signaling pathway involved in axon guidance;","GO:0002116|semaphorin receptor complex;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;","GO:0017154|semaphorin receptor activity;GO:0019904|protein domain specific binding;GO:0051022|Rho GDP-dissociation inhibitor binding;GO:0098632|cell-cell adhesion mediator activity;","K06821","PLXNB; plexin B"]
["ENSRNOG00000007137",4,0.336541075,15,0.964956573,0.348762923,-1.519681421,0.037311976,0.020356509,"down","yes","Ly6i","protein_coding","chr7:107062325-107067310:-","gi|21245088|ref|NP_640350.1|",537,{"v":4e-65,"d":"4.00E-65"},"lymphocyte antigen 6B precursor [Rattus norvegicus]","gi|672059387|ref|XM_008765545.1|",898,0,"PREDICTED: Rattus norvegicus lymphocyte antigen 6 complex, locus I (Ly6i), transcript variant X3, mRNA","Q63317",211,{"v":1e-66,"d":"1.00E-66"},"Lymphocyte antigen 6B",".",".",".",".","pfam00021","UPAR_LY6","u-PAR/Ly-6 domain. This extracellular disulphide bond rich domain is related to pfam00087.","GO:0095500|acetylcholine receptor signaling pathway;GO:2000272|negative regulation of signaling receptor activity;","GO:0005886|plasma membrane;GO:0031225|anchored component of membrane;GO:0045202|synapse;","GO:0030550|acetylcholine receptor inhibitor activity;GO:0033130|acetylcholine receptor binding;","K06846","LY6D_E_F_G6_H; lymphocyte antigen 6 complex locus protein D/E/F/G6/H"]
["ENSRNOG00000018241",4,0.336541075,15,0.964956573,0.348762923,-1.519681421,0.037311976,0.020356509,"down","yes","Ank1","protein_coding","chr16:68877504-69054759:-","gi|74188517|dbj|BAE28015.1|",9654,0,"unnamed protein product [Mus musculus]","gi|530339645|ref|NM_001277289.2|",5595,0,"Mus musculus ankyrin 1, erythroid (Ank1), transcript variant 7, mRNA","Q02357",3672,0,"Ankyrin-1","all2748",189,{"v":7e-50,"d":"7.00E-50"},"COG0666","pfam00791","ZU5","ZU5 domain. Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.","GO:0006779|porphyrin-containing compound biosynthetic process;GO:0006888|ER to Golgi vesicle-mediated transport;GO:0010638|positive regulation of organelle organization;GO:0048821|erythrocyte development;GO:0055072|iron ion homeostasis;GO:0072659|protein localization to plasma membrane;GO:0098662|inorganic cation transmembrane transport;","GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0009898|cytoplasmic side of plasma membrane;GO:0014731|spectrin-associated cytoskeleton;GO:0016020|membrane;GO:0016529|sarcoplasmic reticulum;GO:0030018|Z disc;GO:0030673|axolemma;GO:0030863|cortical cytoskeleton;GO:0031430|M band;GO:0031672|A band;GO:0042383|sarcolemma;GO:0043005|neuron projection;GO:0045211|postsynaptic membrane;","GO:0005515|protein binding;GO:0008093|cytoskeletal adaptor activity;GO:0019899|enzyme binding;GO:0019903|protein phosphatase binding;GO:0030507|spectrin binding;GO:0044325|ion channel binding;GO:0051117|ATPase binding;","K10380","ANK; ankyrin"]
["ENSRNOG00000029321",4,0.336541075,15,0.964956573,0.348762923,-1.519681421,0.037311976,0.020356509,"down","yes","Ccser1","protein_coding","chr4:90292780-91388786:+","gi|256222323|ref|NP_899133.2|",3839,0,"serine-rich coiled-coil domain-containing protein 1 [Mus musculus]","gi|256222359|ref|NM_001164316.1|",2645,0,"Mus musculus coiled-coil serine rich 1 (Ccser1), transcript variant 2, mRNA",".",".",".",".",".",".",".",".","pfam13870","DUF4201","Domain of unknown function (DUF4201). This is a family of coiled-coil proteins from eukaryotes. The function is not known.",".",".",".",".","."]
["ENSRNOG00000047143",4,0.336541075,15,0.964956573,0.348762923,-1.519681421,0.037311976,0.020356509,"down","yes","Fkbp1b","protein_coding","chr6:27838802-27848653:-","gi|12083613|ref|NP_073166.1|",574,{"v":8E-70,"d":"8.00E-70"},"peptidyl-prolyl cis-trans isomerase FKBP1B [Rattus norvegicus]","gi|123173727|ref|NM_016863.3|",752,0,"Mus musculus FK506 binding protein 1b (Fkbp1b), mRNA","P97534",225,{"v":3e-71,"d":"3.00E-71"},"Peptidyl-prolyl cis-trans isomerase FKBP1B","SPBC839.17c",132,{"v":4e-36,"d":"4.00E-36"},"COG0545","pfam00254","FKBP_C","FKBP-type peptidyl-prolyl cis-trans isomerase.","GO:0000413|protein peptidyl-prolyl isomerization;GO:0002027|regulation of heart rate;GO:0006939|smooth muscle contraction;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0009749|response to glucose;GO:0010033|response to organic substance;GO:0010459|negative regulation of heart rate;GO:0010880|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0010881|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;GO:0019227|neuronal action potential propagation;GO:0030073|insulin secretion;GO:0032515|negative regulation of phosphoprotein phosphatase activity;GO:0033197|response to vitamin E;GO:0042098|T cell proliferation;GO:0042542|response to hydrogen peroxide;GO:0048680|positive regulation of axon regeneration;GO:0051209|release of sequestered calcium ion into cytosol;GO:0051280|negative regulation of release of sequestered calcium ion into cytosol;GO:0051284|positive regulation of sequestering of calcium ion;GO:0051480|regulation of cytosolic calcium ion concentration;GO:0051775|response to redox state;GO:0060314|regulation of ryanodine-sensitive calcium-release channel activity;GO:0060315|negative regulation of ryanodine-sensitive calcium-release channel activity;GO:0061077|chaperone-mediated protein folding;GO:0061179|negative regulation of insulin secretion involved in cellular response to glucose stimulus;","GO:0005737|cytoplasm;GO:0016020|membrane;GO:0016529|sarcoplasmic reticulum;GO:0030018|Z disc;GO:0033017|sarcoplasmic reticulum membrane;GO:0034704|calcium channel complex;GO:0043231|intracellular membrane-bounded organelle;","GO:0003755|peptidyl-prolyl cis-trans isomerase activity;GO:0005102|signaling receptor binding;GO:0005528|FK506 binding;GO:0019855|calcium channel inhibitor activity;GO:0030551|cyclic nucleotide binding;GO:0044325|ion channel binding;","K09568","FKBP1; FK506-binding protein 1 [EC:5.2.1.8]"]
["ENSRNOG00000020603",9,0.757217418,25,1.608260955,0.470829946,-1.086722014,0.038250104,0.020717956,"down","yes","Angptl6","protein_coding","chr8:19413619-19419925:-","gi|187469707|gb|AAI66828.1|",1882,0,"Angiopoietin-like 6 [Rattus norvegicus]","gi|157821764|ref|NM_001106702.1|",1564,0,"Rattus norvegicus angiopoietin-like 6 (Angptl6), mRNA","Q8R0Z6",694,0,"Angiopoietin-related protein 6",".",".",".",".","pfam00147","Fibrinogen_C","Fibrinogen beta and gamma chains, C-terminal globular domain.",".","GO:0005615|extracellular space;GO:0030141|secretory granule;GO:0062023|collagen-containing extracellular matrix;","GO:0005102|signaling receptor binding;","K25360","ANGPTL6; angiopoietin-related protein 6"]
["ENSRNOG00000068476",9,0.757217418,25,1.608260955,0.470829946,-1.086722014,0.038250104,0.020717956,"down","yes","RGD1560314","protein_coding","chr7:12164922-12180383:-","gi|672058091|ref|XP_008763411.1|",3444,0,"PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 14 isoform X2 [Rattus norvegicus]","gi|672058090|ref|XM_008765189.1|",2914,0,"PREDICTED: Rattus norvegicus RGD1560314 (RGD1560314), transcript variant X2, mRNA","A2VDQ7",445,{"v":3e-141,"d":"3.00E-141"},"Zinc finger protein 420",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000069437",9,0.757217418,25,1.608260955,0.470829946,-1.086722014,0.038250104,0.020717956,"down","yes","ENSRNOG00000069437","lncRNA","chr3:105821651-105824102:+","gi|33086552|gb|AAP92588.1|",154,1e-07,"Ab2-076 [Rattus norvegicus]","gi|755472881|ref|XR_886101.1|",310,{"v":3e-159,"d":"3.00E-159"},"PREDICTED: Mus musculus uncharacterized LOC105244272 (LOC105244272), transcript variant X1, ncRNA",".",".",".",".",".",".",".",".","pfam14540","NTF-like","Nucleotidyltransferase-like. Structural comparisons with PDB:1kny indicate that this N-terminal domain resembles a nucleotidyltransferase fold.",".",".",".",".","."]
["ENSRNOG00000002224",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","Yipf7","protein_coding","chr14:38571066-38599055:+","gi|564383867|ref|XP_006251101.1|",1354,0,"PREDICTED: protein YIPF7 isoform X2 [Rattus norvegicus]","gi|298901146|emb|FQ215959.1|",1182,0,"Rattus norvegicus TL0ACA45YK06 mRNA sequence","Q9JIM5",475,{"v":4E-167,"d":"4.00E-167"},"Protein YIPF7","SPCC61.04c",166,{"v":2e-47,"d":"2.00E-47"},"COG5080","pfam04893","Yip1","Yip1 domain. The Yip1 integral membrane domain contains four transmembrane alpha helices. The domain is characterized by the motifs DLYGP and GY. The Yip1 protein is a golgi protein involved in vesicular transport that interacts with GTPases.","GO:0006888|ER to Golgi vesicle-mediated transport;GO:0048280|vesicle fusion with Golgi apparatus;","GO:0005802|trans-Golgi network;GO:0016021|integral component of membrane;",".","K20363","YIPF5_7, YIP1; protein YIPF5/7"]
["ENSRNOG00000002346",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","Tbx22","protein_coding","chrX:72723617-72774647:+","gi|564399798|ref|XP_006257223.1|",2433,0,"PREDICTED: T-box transcription factor TBX22 isoform X3 [Rattus norvegicus]","gi|157818350|ref|NM_001106937.1|",4834,0,"Rattus norvegicus T-box 22 (Tbx22), mRNA","Q8K402",823,0,"T-box transcription factor TBX22",".",".",".",".","pfam00907","T-box","T-box. The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001708|cell fate specification;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008150|biological_process;GO:0045892|negative regulation of transcription, DNA-templated;","GO:0005575|cellular_component;GO:0005634|nucleus;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003677|DNA binding;","K10186","TBX22; T-box protein 22"]
["ENSRNOG00000002593",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","Esrrg","protein_coding","chr13:99564669-99783397:+","gi|6753774|ref|NP_036065.1|",2372,0,"estrogen-related receptor gamma isoform1 [Mus musculus]","gi|672075170|ref|XM_006250443.2|",3074,0,"PREDICTED: Rattus norvegicus estrogen-related receptor gamma (Esrrg), transcript variant X1, mRNA","P62510",917,0,"Estrogen-related receptor gamma",".",".",".",".","pfam00105","zf-C4","Zinc finger, C4 type (two domains). In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.","GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0043401|steroid hormone mediated signaling pathway;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048384|retinoic acid receptor signaling pathway;GO:0120162|positive regulation of cold-induced thermogenesis;","GO:0005634|nucleus;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003707|steroid hormone receptor activity;GO:0004879|nuclear receptor activity;GO:0005496|steroid binding;GO:0008270|zinc ion binding;GO:0042802|identical protein binding;GO:0050682|AF-2 domain binding;GO:1990837|sequence-specific double-stranded DNA binding;","K08554","NR3B3, ESRRG; estrogen-related receptor gamma"]
["ENSRNOG00000004112",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","RGD1308775","protein_coding","chr14:78781315-78789956:-","gi|157821851|ref|NP_001100703.1|",882,{"v":7e-110,"d":"7.00E-110"},"uncharacterized protein C5orf52 homolog [Rattus norvegicus]","gi|157821850|ref|NM_001107233.1|",2518,0,"Rattus norvegicus similar to RIKEN cDNA 4921536K21 (RGD1308775), mRNA",".",".",".",".",".",".",".",".","pfam11561","Saw1","Single strand annealing-weakened 1. This family of yeast proteins is involved in single-strand-annealing, or SSA. SSA entails multiple steps: end resection and ssDNA formation; annealing of complementary ssDNAs; removal of 3' single-stranded non-homologous tails; gap fill-in synthesis; and ligation. Saw1 in combination with Slx4 catalyses the 3' non-homologous tail removal during recombination. Saw1 interacts physically with Rad1/Rad10, Msh2/Msh3, and Rad52 proteins, and works by targeting Rad1/Rad10 to Rad52-coated recombination intermediates.",".",".",".",".","."]
["ENSRNOG00000004795",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","Pof1b","protein_coding","chrX:77683128-77749688:-","gi|157818163|ref|NP_001100404.1|",2705,0,"protein POF1B [Rattus norvegicus]","gi|157818162|ref|NM_001106934.1|",3877,0,"Rattus norvegicus premature ovarian failure 1B (Pof1b), mRNA","Q8K4L4",1017,0,"Protein POF1B",".",".",".",".","pfam10174","Cast","RIM-binding protein of the cytomatrix active zone. This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.","GO:0003382|epithelial cell morphogenesis;GO:0007015|actin filament organization;GO:0030036|actin cytoskeleton organization;GO:0070830|bicellular tight junction assembly;","GO:0005884|actin filament;GO:0005912|adherens junction;GO:0005923|bicellular tight junction;GO:0030057|desmosome;","GO:0051015|actin filament binding;","K23917","POF1B; protein POF1B"]
["ENSRNOG00000005246",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","Tfap2c","protein_coding","chr3:161315031-161322995:+","gi|564344758|ref|XP_006235753.1|",2296,0,"PREDICTED: transcription factor AP-2 gamma isoform X1 [Rattus norvegicus]","gi|672048157|ref|XM_006235691.2|",1751,0,"PREDICTED: Rattus norvegicus transcription factor AP-2 gamma (Tfap2c), transcript variant X1, mRNA","Q61312",764,0,"Transcription factor AP-2 gamma",".",".",".",".","pfam03299","TF_AP-2","Transcription factor AP-2.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001829|trophectodermal cell differentiation;GO:0001942|hair follicle development;GO:0003334|keratinocyte development;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008150|biological_process;GO:0008584|male gonad development;GO:0019827|stem cell population maintenance;GO:0021877|forebrain neuron fate commitment;GO:0021987|cerebral cortex development;GO:0030154|cell differentiation;GO:0030718|germ-line stem cell population maintenance;GO:0035019|somatic stem cell population maintenance;GO:0040029|regulation of gene expression, epigenetic;GO:0042127|regulation of cell proliferation;GO:0043588|skin development;GO:0045682|regulation of epidermis development;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048733|sebaceous gland development;GO:0048856|anatomical structure development;GO:0060598|dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis;GO:0060750|epithelial cell proliferation involved in mammary gland duct elongation;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005739|mitochondrion;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:1990837|sequence-specific double-stranded DNA binding;","K09177","TFAP2C; transcription factor AP-2 gamma"]
["ENSRNOG00000008242",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","RGD1305207","protein_coding","chr7:132561724-132571944:+","gi|62079271|ref|NP_001014289.1|",659,{"v":3e-83,"d":"3.00E-83"},"uncharacterized protein LOC366990 [Rattus norvegicus]","gi|62079270|ref|NM_001014267.1|",820,0,"Rattus norvegicus similar to RIKEN cDNA 1700011A15 (RGD1305207), mRNA","P15241",91.3,{"v":2E-19,"d":"2.00E-19"},"Keratin, type II microfibrillar, component 7C",".",".",".",".","pfam00038","Filament","Intermediate filament protein.",".","GO:0005882|intermediate filament;",".",".","."]
["ENSRNOG00000009193",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","Lctl","protein_coding","chr8:64618350-64639357:+","gi|149041944|gb|EDL95785.1|",2655,0,"lactase-like (predicted), isoform CRA_a [Rattus norvegicus]","gi|141802015|ref|NM_145835.2|",1304,0,"Mus musculus lactase-like (Lctl), mRNA","Q8K1F9",942,0,"Lactase-like protein","BH1923",228,{"v":2e-64,"d":"2.00E-64"},"COG2723","pfam00232","Glyco_hydro_1","Glycosyl hydrolase family 1.","GO:0002089|lens morphogenesis in camera-type eye;GO:0005975|carbohydrate metabolic process;","GO:0005783|endoplasmic reticulum;GO:0005903|brush border;","GO:0008422|beta-glucosidase activity;",".","."]
["ENSRNOG00000009284",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","Foxa1","protein_coding","chr6:75103503-75136188:-","gi|148704754|gb|EDL36701.1|",1978,0,"forkhead box A1, partial [Mus musculus]","gi|1177218|gb|U44752.1|MMU44752",2167,0,"Mus musculus hepatocyte nuclear factor 3 alpha (HNF-3A) mRNA, complete cds","P35582",748,0,"Hepatocyte nuclear factor 3-alpha","ECU11g1330",97.1,{"v":5e-21,"d":"5.00E-21"},"COG5025","pfam00250","Fork_head","Fork head domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006338|chromatin remodeling;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007219|Notch signaling pathway;GO:0009653|anatomical structure morphogenesis;GO:0010468|regulation of gene expression;GO:0010719|negative regulation of epithelial to mesenchymal transition;GO:0021904|dorsal/ventral neural tube patterning;GO:0030154|cell differentiation;GO:0030324|lung development;GO:0032355|response to estradiol;GO:0033148|positive regulation of intracellular estrogen receptor signaling pathway;GO:0035239|tube morphogenesis;GO:0042445|hormone metabolic process;GO:0042593|glucose homeostasis;GO:0043065|positive regulation of apoptotic process;GO:0045666|positive regulation of neuron differentiation;GO:0045880|positive regulation of smoothened signaling pathway;GO:0045931|positive regulation of mitotic cell cycle;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048646|anatomical structure formation involved in morphogenesis;GO:0048665|neuron fate specification;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051726|regulation of cell cycle;GO:0060425|lung morphogenesis;GO:0060441|epithelial tube branching involved in lung morphogenesis;GO:0060487|lung epithelial cell differentiation;GO:0060528|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development;GO:0060738|epithelial-mesenchymal signaling involved in prostate gland development;GO:0060740|prostate gland epithelium morphogenesis;GO:0060741|prostate gland stromal morphogenesis;GO:0060743|epithelial cell maturation involved in prostate gland development;GO:0061144|alveolar secondary septum development;GO:0061448|connective tissue development;GO:1902691|respiratory basal cell differentiation;","GO:0001650|fibrillar center;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005902|microvillus;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003690|double-stranded DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0019904|protein domain specific binding;GO:0043565|sequence-specific DNA binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09387","FOXA1, HNF3A; forkhead box protein A1, hepatocyte nuclear factor 3-alpha"]
["ENSRNOG00000013018",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","ENSRNOG00000013018","protein_coding","chrX:62228229-62269268:-","gi|564322817|ref|XP_006227428.1|",1451,0,"PREDICTED: tumor necrosis factor receptor superfamily member 27 isoform X2 [Rattus norvegicus]","gi|672032387|ref|XM_006227365.2|",1542,0,"PREDICTED: Rattus norvegicus ectodysplasin A2 receptor (Eda2r), transcript variant X2, mRNA","Q8BX35",522,{"v":2e-177,"d":"2.00E-177"},"Tumor necrosis factor receptor superfamily member 27",".",".",".",".","pfam00020","TNFR_c6","TNFR/NGFR cysteine-rich region.","GO:0033209|tumor necrosis factor-mediated signaling pathway;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0046330|positive regulation of JNK cascade;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0072332|intrinsic apoptotic signaling pathway by p53 class mediator;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;","GO:0005031|tumor necrosis factor-activated receptor activity;GO:0038023|signaling receptor activity;","K05163","EDA2R, TNFRSF27, XEDAR; tumor necrosis factor receptor superfamily member 27"]
["ENSRNOG00000013407",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","Slc5a11","protein_coding","chr1:177756561-177795193:+","gi|686661095|ref|NP_001093952.2|",3150,0,"sodium/myo-inositol cotransporter 2 [Rattus norvegicus]","gi|672037710|ref|XM_006230186.2|",2091,0,"PREDICTED: Rattus norvegicus solute carrier family 5 (sodium/inositol cotransporter), member 11 (Slc5a11), transcript variant X1, mRNA","Q9Z1F2",1192,0,"Sodium/myo-inositol cotransporter 2","BH2222",148,{"v":4e-37,"d":"4.00E-37"},"COG4146","pfam00474","SSF","Sodium:solute symporter family. Membership of this family is supported by a significant blast score.","GO:0006814|sodium ion transport;GO:0006915|apoptotic process;GO:0032409|regulation of transporter activity;GO:0055085|transmembrane transport;GO:1904659|glucose transmembrane transport;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;","GO:0005412|glucose:sodium symporter activity;GO:0022857|transmembrane transporter activity;","K14391","SLC5A11, SMIT2, SGLT6; solute carrier family 5 (sodium/myo-inositol cotransporter), member 11"]
["ENSRNOG00000017180",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","Slc17a2","protein_coding","chr17:41319701-41336325:-","gi|157824099|ref|NP_001100823.1|",2082,0,"sodium-dependent phosphate transport protein 3 [Rattus norvegicus]","gi|157824098|ref|NM_001107353.1|",2822,0,"Rattus norvegicus solute carrier family 17, member 2 (Slc17a2), mRNA","Q5SZA1",766,0,"Sodium-dependent phosphate transport protein 3",".",".",".",".","pfam07690","MFS_1","Major Facilitator Superfamily.","GO:0006820|anion transport;GO:0015739|sialic acid transport;GO:0055085|transmembrane transport;","GO:0005764|lysosome;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;","GO:0015136|sialic acid transmembrane transporter activity;GO:0022857|transmembrane transporter activity;","K12300","SLC17A1S; MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 1/2/3/4"]
["ENSRNOG00000022116",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","Gjb6","protein_coding","chr15:31284419-31294582:-","gi|58331126|ref|NP_001010937.1|",1411,{"v":4E-175,"d":"4.00E-175"},"gap junction beta-6 protein [Mus musculus]","gi|672078401|ref|XM_008770783.1|",1466,0,"PREDICTED: Rattus norvegicus gap junction protein, beta 6 (Gjb6), transcript variant X5, mRNA","P70689",548,{"v":1E-176,"d":"1.00E-176"},"Gap junction beta-6 protein",".",".",".",".","pfam00029","Connexin","Connexin.","GO:0006915|apoptotic process;GO:0007267|cell-cell signaling;GO:0007568|aging;GO:0007605|sensory perception of sound;GO:0008285|negative regulation of cell proliferation;GO:0010644|cell communication by electrical coupling;GO:0016264|gap junction assembly;GO:0032496|response to lipopolysaccharide;GO:0042471|ear morphogenesis;GO:0048839|inner ear development;GO:0051602|response to electrical stimulus;GO:0055085|transmembrane transport;GO:0071333|cellular response to glucose stimulus;GO:1990349|gap junction-mediated intercellular transport;","GO:0005829|cytosol;GO:0005884|actin filament;GO:0005921|gap junction;GO:0005922|connexin complex;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0030054|cell junction;","GO:0003674|molecular_function;GO:0005243|gap junction channel activity;GO:0008017|microtubule binding;GO:0048487|beta-tubulin binding;GO:0051015|actin filament binding;GO:1903763|gap junction channel activity involved in cell communication by electrical coupling;","K07625","GJB6, CX30; gap junction beta-6 protein"]
["ENSRNOG00000023457",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","Stpg2","protein_coding","chr2:227764353-228285663:+","gi|155369668|ref|NP_001094463.1|",3009,0,"sperm-tail PG-rich repeat-containing protein 2 [Rattus norvegicus]","gi|155369667|ref|NM_001100993.1|",1900,0,"Rattus norvegicus sperm-tail PG-rich repeat containing 2 (Stpg2), mRNA",".",".",".",".",".",".",".",".","pfam00274","Glycolytic","Fructose-bisphosphate aldolase class-I.",".",".",".",".","."]
["ENSRNOG00000023828",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","ENSRNOG00000023828","protein_coding","chr7:107838080-107845981:-","gi|392341530|ref|XP_003754360.1|",3590,0,"PREDICTED: uncharacterized protein LOC680875 [Rattus norvegicus]","gi|672022041|ref|XM_008776501.1|",2532,0,"PREDICTED: Rattus norvegicus similar to dystonin isoform 1 (LOC680875), transcript variant X2, mRNA","Q9UPN3",68.2,{"v":4e-10,"d":"4.00E-10"},"Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5",".",".",".",".","pfam02187","GAS2","Growth-Arrest-Specific Protein 2 Domain.","GO:0032886|regulation of microtubule-based process;GO:0042060|wound healing;GO:0045104|intermediate filament cytoskeleton organization;GO:0051893|regulation of focal adhesion assembly;","GO:0005737|cytoplasm;GO:0005874|microtubule;GO:0005882|intermediate filament;GO:0015629|actin cytoskeleton;GO:0016020|membrane;","GO:0005198|structural molecule activity;GO:0008017|microtubule binding;",".","."]
["ENSRNOG00000024093",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","Dmrta1","protein_coding","chr5:104415893-104422433:+","gi|157822065|ref|NP_001101415.1|",2163,0,"doublesex- and mab-3-related transcription factor A1 [Rattus norvegicus]","gi|157822064|ref|NM_001107945.1|",4030,0,"Rattus norvegicus DMRT-like family A1 (Dmrta1), mRNA","Q8CFG4",775,0,"Doublesex- and mab-3-related transcription factor A1",".",".",".",".","pfam00751","DM","DM DNA binding domain. The DM domain is named after dsx and mab-3. dsx contains a single amino-terminal DM domain, whereas mab-3 contains two amino-terminal domains. The DM domain has a pattern of conserved zinc chelating residues C2H2C4. The dsx DM domain has been shown to dimerise and bind palindromic DNA.","GO:0001541|ovarian follicle development;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007281|germ cell development;GO:0007548|sex differentiation;GO:0060179|male mating behavior;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0042802|identical protein binding;GO:0043565|sequence-specific DNA binding;GO:0046872|metal ion binding;GO:1990837|sequence-specific double-stranded DNA binding;","K19491","DMRT4_5, DMRTA; doublesex- and mab-3-related transcription factor 4/5"]
["ENSRNOG00000024640",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","Oacyl","protein_coding","chr18:59212354-59263722:+","gi|157817521|ref|NP_001099609.1|",3412,0,"O-acyltransferase like precursor [Rattus norvegicus]","gi|157817520|ref|NM_001106139.1|",3423,0,"Rattus norvegicus O-acyltransferase like (Oacyl), mRNA","Q8BML2",1202,0,"O-acyltransferase like protein",".",".",".",".","pfam01757","Acyl_transf_3","Acyltransferase family. This family includes a range of acyltransferase enzymes. This domain is found in many as yet uncharacterized C. elegans proteins and it is approximately 300 amino acids long.",".","GO:0016021|integral component of membrane;","GO:0016747|transferase activity, transferring acyl groups other than amino-acyl groups;",".","."]
["ENSRNOG00000026067",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","Wfdc10a","protein_coding","chr3:153390067-153391420:+","gi|157822635|ref|NP_001102931.1|",568,{"v":3e-72,"d":"3.00E-72"},"WAP four-disulfide core domain 10 precursor [Rattus norvegicus]","gi|157822634|ref|NM_001109461.1|",468,0,"Rattus norvegicus WAP four-disulfide core domain 10 (Wfdc10), mRNA","Q9H1F0",75.9,{"v":6e-17,"d":"6.00E-17"},"WAP four-disulfide core domain protein 10A",".",".",".",".","pfam00095","WAP","WAP-type (Whey Acidic Protein) 'four-disulfide core'.","GO:0010951|negative regulation of endopeptidase activity;GO:0019731|antibacterial humoral response;GO:0045087|innate immune response;","GO:0005615|extracellular space;","GO:0004867|serine-type endopeptidase inhibitor activity;",".","."]
["ENSRNOG00000027908",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","Actrt3","protein_coding","chr2:112799011-112801075:+","gi|157822087|ref|NP_001102412.1|",1996,0,"actin-related protein T3 [Rattus norvegicus]","gi|157822086|ref|NM_001108942.1|",1116,0,"Rattus norvegicus actin-related protein T3 (Actrt3), mRNA","Q8BXF8",714,0,"Actin-related protein T3","YFL039c",395,{"v":4e-134,"d":"4.00E-134"},"COG5277","pfam00022","Actin","Actin.",".","GO:0001673|male germ cell nucleus;",".",".","."]
["ENSRNOG00000029814",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","Prtn3","protein_coding","chr7:9822122-9831944:-","gi|149034642|gb|EDL89379.1|",1234,{"v":1e-162,"d":"1.00E-162"},"proteinase 3 (predicted) [Rattus norvegicus]","gi|88608890|gb|AC131405.5|",1247,0,"Rattus norvegicus BAC CH230-179I7 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q61096",454,{"v":3e-154,"d":"3.00E-154"},"Myeloblastin","VC1200",80.9,{"v":3e-15,"d":"3.00E-15"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;GO:0006509|membrane protein ectodomain proteolysis;GO:0006909|phagocytosis;GO:0043547|positive regulation of GTPase activity;GO:0045217|cell-cell junction maintenance;GO:0050765|negative regulation of phagocytosis;GO:0072672|neutrophil extravasation;GO:0097029|mature conventional dendritic cell differentiation;","GO:0005615|extracellular space;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0035578|azurophil granule lumen;GO:0043231|intracellular membrane-bounded organelle;GO:0044853|plasma membrane raft;","GO:0004252|serine-type endopeptidase activity;GO:0005102|signaling receptor binding;GO:0019899|enzyme binding;","K01350","PRTN3; myeloblastin [EC:3.4.21.76]"]
["ENSRNOG00000032461",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","Bin2a","protein_coding","chr8:25248570-25287173:-","gi|564362841|ref|XP_006242799.1|",3402,0,"PREDICTED: beta-galactosidase-like protein isoform X1 [Rattus norvegicus]","gi|57222331|ref|NM_001009524.1|",2584,0,"Rattus norvegicus beta-galactosidase-like protein (Bin2a), mRNA","Q8IW92",597,0,"Beta-galactosidase-1-like protein 2","XF0840",342,{"v":5e-105,"d":"5.00E-105"},"COG1874","pfam01301","Glyco_hydro_35","Glycosyl hydrolases family 35.","GO:0005975|carbohydrate metabolic process;","GO:0005773|vacuole;","GO:0004565|beta-galactosidase activity;",".","."]
["ENSRNOG00000035618",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","Mir345","miRNA","chr6:127754027-127754122:+",".",".",".",".","gi|354794315|gb|JN958816.1|",96,{"v":8e-42,"d":"8.00E-42"},"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Slc25a29:tm1a(KOMP)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam15402","Spc7_N","N-terminus of kinetochore NMS complex subunit Spc7.","GO:0007605|sensory perception of sound;GO:0009617|response to bacterium;GO:0060291|long-term synaptic potentiation;GO:0071222|cellular response to lipopolysaccharide;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0016442|RISC complex;",".","K17375","MIR345; microRNA 345"]
["ENSRNOG00000049853",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","ENSRNOG00000049853","protein_coding","chrX:106714868-106719794:+","gi|564323200|ref|XP_003754878.2|",6617,0,"PREDICTED: retrotransposon gag domain-containing protein 1 [Rattus norvegicus]","gi|672032662|ref|XM_008758535.1|",4333,0,"PREDICTED: Rattus norvegicus retrotransposon gag domain containing 1 (LOC100912526), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam05109","Herpes_BLLF1","Herpes virus major outer envelope glycoprotein (BLLF1). This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralizing antibodies in vivo.",".",".",".",".","."]
["ENSRNOG00000055586",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","ENSRNOG00000055586","protein_coding","chr11:67976794-67982396:+","gi|392332348|ref|XP_003752550.1|",741,{"v":2e-96,"d":"2.00E-96"},"PREDICTED: uncharacterized protein LOC100910650 isoform X1 [Rattus norvegicus]","gi|672026141|ref|XM_003752502.3|",743,0,"PREDICTED: Rattus norvegicus uncharacterized LOC100910650 (LOC100910650), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam01033","Somatomedin_B","Somatomedin B domain.",".",".",".",".","."]
["ENSRNOG00000060156",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","SNORD28","snoRNA","chr1:205620424-205620501:+",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","pfam00827","Ribosomal_L15e","Ribosomal L15.",".",".",".",".","."]
["ENSRNOG00000061530",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","ENSRNOG00000061530","protein_coding","chrX:70817433-70878717:+","gi|11177916|ref|NP_068639.1|",1086,{"v":2e-143,"d":"2.00E-143"},"fibroblast growth factor 16 [Rattus norvegicus]","gi|55250401|gb|BC085738.1|",1630,0,"Rattus norvegicus fibroblast growth factor 16, mRNA (cDNA clone MGC:93457 IMAGE:7189721), complete cds","O54769",422,{"v":6e-145,"d":"6.00E-145"},"Fibroblast growth factor 16",".",".",".",".","pfam00167","FGF","Fibroblast growth factor. Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide range of contexts. They are found in a wide range of organisms, from nematodes to humans. Most share an internal core region of high similarity, conserved residues in which are involved in binding with their receptors. On binding, they cause dimerization of their tyrosine kinase receptors leading to intracellular signalling. There are currently four known tyrosine kinase receptors for fibroblast growth factors. These receptors can each bind several different members of this family. Members of this family have a beta trefoil structure. Most have N-terminal signal peptides and are secreted. A few lack signal sequences but are secreted anyway; still others also lack the signal peptide but are found on the cell surface and within the extracellular matrix. A third group remain intracellular. They have central roles in development, regulating cell proliferation, migration and differentiation. On the other hand, they are important in tissue repair following injury in adult organisms.","GO:0001934|positive regulation of protein phosphorylation;GO:0008284|positive regulation of cell proliferation;GO:0008543|fibroblast growth factor receptor signaling pathway;GO:0009887|animal organ morphogenesis;GO:0010628|positive regulation of gene expression;GO:0030154|cell differentiation;GO:0030334|regulation of cell migration;GO:0070349|positive regulation of brown fat cell proliferation;GO:2000546|positive regulation of endothelial cell chemotaxis to fibroblast growth factor;","GO:0005615|extracellular space;GO:0005737|cytoplasm;","GO:0005104|fibroblast growth factor receptor binding;GO:0008083|growth factor activity;","K04358","FGF; fibroblast growth factor"]
["ENSRNOG00000062994",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","ENSRNOG00000062994","protein_coding","chrX:132703263-132703769:+","gi|109511234|ref|XP_228669.3|",681,{"v":2e-88,"d":"2.00E-88"},"PREDICTED: high mobility group protein B4-like [Rattus norvegicus]","gi|672033140|ref|XM_008758130.1|",507,0,"PREDICTED: Rattus norvegicus similar to RIKEN cDNA 1700001F22 (RGD1561558), mRNA","Q6P8W9",175,{"v":6e-54,"d":"6.00E-54"},"High mobility group protein B4","SPAC57A10.09c",47,1e-06,"COG5648","pfam00505","HMG_box","HMG (high mobility group) box.",".",".",".",".","."]
["ENSRNOG00000064421",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","ENSRNOG00000064421","protein_coding","chr1:85413938-85414801:+",".",".",".",".","gi|298913958|emb|FQ219686.1|",271,{"v":3e-138,"d":"3.00E-138"},"Rattus norvegicus TL0ABA43YK13 mRNA sequence",".",".",".",".",".",".",".",".","pfam15449","Retinal","Retinal protein. This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.",".",".",".",".","."]
["ENSRNOG00000065574",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","Mug2","protein_coding","chr4:155164011-155236475:+","gi|50657404|ref|NP_001002826.1|",7196,0,"murinoglobulin-2 precursor [Rattus norvegicus]","gi|672050893|ref|XM_006237282.2|",2117,0,"PREDICTED: Rattus norvegicus murinoglobulin 1 (Mug1), transcript variant X1, mRNA","Q6IE52",2776,0,"Murinoglobulin-2","TM0984",72,{"v":1e-11,"d":"1.00E-11"},"COG2373","pfam07678","A2M_comp","A-macroglobulin complement component. This family includes the complement components region of the alpha-2-macroglobulin family.",".",".",".",".","."]
["ENSRNOG00000066174",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","ENSRNOG00000066174","protein_coding","chr1:201787072-201792824:-","gi|558142821|ref|XP_006092739.1|",683,{"v":3E-124,"d":"3.00E-124"},"PREDICTED: ADP/ATP translocase 1 [Myotis lucifugus]","gi|672014565|ref|XM_008774757.1|",648,0,"PREDICTED: Rattus norvegicus similar to solute carrier family 25, member 5 (LOC689073), mRNA","P05141",291,{"v":2e-86,"d":"2.00E-86"},"ADP/ATP translocase 2",".",".",".",".","pfam00153","Mito_carr","Mitochondrial carrier protein.",".",".",".",".","."]
["ENSRNOG00000068990",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","Olr161","protein_coding","chr1:158941776-158944225:+","gi|47576505|ref|NP_001001000.1|",1549,0,"olfactory receptor Olr161 [Rattus norvegicus]","gi|90855788|gb|AC128039.4|",1253,0,"Rattus norvegicus BAC CH230-394A24 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q8NGI1",507,{"v":4E-176,"d":"4.00E-176"},"Putative olfactory receptor 56B2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.",".",".",".",".","."]
["ENSRNOG00000069426",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","ENSRNOG00000069426","lncRNA","chr20:26763850-26764944:+","gi|26348957|dbj|BAC38118.1|",445,{"v":2e-57,"d":"2.00E-57"},"unnamed protein product [Mus musculus]","gi|62000723|gb|AC153367.5|",765,0,"Mus musculus 10 BAC RP23-182A11 (Roswell Park Cancer Institute (C57BL/6J Female) Mouse BAC Library) complete sequence",".",".",".",".",".",".",".",".","pfam14927","Neurensin","Neurensin. The neurensin family includes the neuronal membrane proteins neurensin-1 and neurensin-2. Neurensin-1 plays a role in neurite extension.",".",".",".",".","."]
["ENSRNOG00000069844",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","ENSRNOG00000069844","lncRNA","chr13:92304945-92307559:-",".",".",".",".","gi|56847|emb|X65496.1|",236,{"v":2E-118,"d":"2.00E-118"},"R.norvegicus gene for poly(ADP-ribose) polymerase (clone pGrat5')",".",".",".",".",".",".",".",".","pfam03838","RecU","Recombination protein U.",".",".",".",".","."]
["ENSRNOG00000070049",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","ENSRNOG00000070049","protein_coding","chr9:113866732-113885569:+","gi|564349898|ref|XP_006237776.1|",2967,0,"PREDICTED: zinc finger protein 431-like isoform X2 [Rattus norvegicus]","gi|672051759|ref|XM_006237714.2|",1840,0,"PREDICTED: Rattus norvegicus zinc finger protein 709-like (LOC102550397), transcript variant X2, mRNA","E9QAG8",685,0,"Zinc finger protein 431","SPAC144.09c",115,{"v":1E-26,"d":"1.00E-26"},"COG5048","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000070243",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","ENSRNOG00000070243","lncRNA","chr3:115425261-115447917:+","gi|148675219|gb|EDL07166.1|",129,2e-07,"mCG1028420, partial [Mus musculus]","gi|672017320|ref|XR_345179.2|",368,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102555576 (LOC102555576), transcript variant X1, ncRNA",".",".",".",".",".",".",".",".","pfam00852","Glyco_transf_10","Glycosyltransferase family 10 (fucosyltransferase). This family of Fucosyltransferases are the enzymes transferring fucose from GDP-Fucose to GlcNAc in an alpha1,3 linkage. This family is know as glycosyltransferase family 10.",".",".",".",".","."]
["ENSRNOG00000070452",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","ENSRNOG00000070452","lncRNA","chr2:38343050-38352167:+",".",".",".",".","gi|672041406|ref|XM_006231903.2|",473,0,"PREDICTED: Rattus norvegicus DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae) (Dimt1), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam08324","PUL","PUL domain. The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated domain. It directly binds to Cdc48, a chaperone-like AAA ATPase that collects ubiquitylated substrates.",".",".",".",".","."]
["ENSRNOG00000070466",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","ENSRNOG00000070466","pseudogene","chr9:15260659-15261424:+","gi|148691515|gb|EDL23462.1|",341,{"v":4e-39,"d":"4.00E-39"},"mCG147804 [Mus musculus]","gi|755559088|ref|XM_006524968.2|",222,{"v":3e-111,"d":"3.00E-111"},"PREDICTED: Mus musculus RIKEN cDNA 1600014C23 gene (1600014C23Rik), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam15242","FAM53","Family of FAM53. The FAM53 protein family refers to a family of proteins, which bind to a transcriptional regulator that modulates cell proliferation. It is known to be highly important in neural tube development. It is found in eukaryotes and is typically between 303 and 413 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000070633",0,0.042067634,6,0.385982629,0.108988413,-3.197753326,0.03826747,0.020717956,"down","yes","ENSRNOG00000070633","protein_coding","chr15:24257489-24258627:+","gi|575403030|ref|NP_001276405.1|",437,{"v":4E-51,"d":"4.00E-51"},"proteasome subunit alpha type-7 isoform 2 [Mus musculus]","gi|14198317|gb|BC008222.1|",233,{"v":5E-117,"d":"5.00E-117"},"Mus musculus proteasome (prosome, macropain) subunit, alpha type 7, mRNA (cDNA clone MGC:6440 IMAGE:2581897), complete cds","O14818",173,{"v":5E-52,"d":"5.00E-52"},"Proteasome subunit alpha type-7",".",".",".",".","pfam00227","Proteasome","Proteasome subunit. The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria. The second is call beta-proteobacteria proteasome homologue (BPH).",".",".",".",".","."]
["ENSRNOG00000017503",8,0.673082149,23,1.479600078,0.45490816,-1.136352781,0.039348444,0.021246777,"down","yes","Ppargc1b","protein_coding","chr18:54758902-54861194:-","gi|108860902|sp|Q811R2.2|PRGC2_RAT",4180,0,"RecName: Full=Peroxisome proliferator-activated receptor gamma coactivator 1-beta; Short=PGC-1-beta; Short=PPAR-gamma coactivator 1-beta; Short=PPARGC-1-beta","gi|31341573|ref|NM_176075.2|",3123,0,"Rattus norvegicus PPARG coactivator 1 beta (Ppargc1b), mRNA","Q811R2",1614,0,"Peroxisome proliferator-activated receptor gamma coactivator 1-beta",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0001503|ossification;GO:0006355|regulation of transcription, DNA-templated;GO:0006390|mitochondrial transcription;GO:0007015|actin filament organization;GO:0010694|positive regulation of alkaline phosphatase activity;GO:0030520|intracellular estrogen receptor signaling pathway;GO:0034614|cellular response to reactive oxygen species;GO:0042327|positive regulation of phosphorylation;GO:0045672|positive regulation of osteoclast differentiation;GO:0045780|positive regulation of bone resorption;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051384|response to glucocorticoid;GO:0051591|response to cAMP;GO:0060346|bone trabecula formation;GO:0120162|positive regulation of cold-induced thermogenesis;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;GO:0016592|mediator complex;","GO:0003674|molecular_function;GO:0003712|transcription coregulator activity;GO:0003723|RNA binding;GO:0008134|transcription factor binding;GO:0030331|estrogen receptor binding;GO:0030374|nuclear receptor transcription coactivator activity;GO:0050682|AF-2 domain binding;","K17962","PPARGC1B, PGC1B; peroxisome proliferator-activated receptor gamma coactivator 1-beta"]
["ENSRNOG00000023551",8,0.673082149,23,1.479600078,0.45490816,-1.136352781,0.039348444,0.021246777,"down","yes","Sp6","protein_coding","chr10:82005294-82011013:+","gi|402899442|ref|XP_003912706.1|",1761,0,"PREDICTED: transcription factor Sp6 isoform X1 [Papio anubis]","gi|157819102|ref|NM_001108833.1|",1995,0,"Rattus norvegicus Sp6 transcription factor (Sp6), mRNA","Q9ESX2",653,0,"Transcription factor Sp6",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0008284|positive regulation of cell proliferation;GO:0042481|regulation of odontogenesis;","GO:0005634|nucleus;GO:0005829|cytosol;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;","K09196","SP6; transcription factor Sp6"]
["ENSRNOG00000032895",8,0.673082149,23,1.479600078,0.45490816,-1.136352781,0.039348444,0.021246777,"down","yes","Cyp4f4","protein_coding","chr7:11717208-11733506:+","gi|27465575|ref|NP_775146.1|",2462,0,"cytochrome P450 4F4 [Rattus norvegicus]","gi|27465574|ref|NM_173123.1|",1549,0,"Rattus norvegicus cytochrome P450, family 4, subfamily f, polypeptide 4 (Cyp4f4), mRNA","P51869",951,0,"Cytochrome P450 4F4","AGc2890",147,{"v":4e-37,"d":"4.00E-37"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0019369|arachidonic acid metabolic process;GO:0036101|leukotriene B4 catabolic process;GO:0042361|menaquinone catabolic process;GO:0042376|phylloquinone catabolic process;GO:0042377|vitamin K catabolic process;GO:0097267|omega-hydroxylase P450 pathway;GO:1905344|prostaglandin catabolic process;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0005506|iron ion binding;GO:0008391|arachidonic acid monooxygenase activity;GO:0020037|heme binding;GO:0050051|leukotriene-B4 20-monooxygenase activity;","K00490","CYP4F; cytochrome P450 family 4 subfamily F [EC:1.14.14.1]"]
["ENSRNOG00000033719",8,0.673082149,23,1.479600078,0.45490816,-1.136352781,0.039348444,0.021246777,"down","yes","Pcdhb12","protein_coding","chr18:29139746-29142764:+","gi|564393200|ref|XP_006254688.1|",3876,0,"PREDICTED: protocadherin-3 isoform X1 [Rattus norvegicus]","gi|86440007|gb|AC096374.7|",3019,0,"Rattus norvegicus BAC CH230-17K7 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q63418",1486,0,"Protocadherin-3",".",".",".",".","pfam08266","Cadherin_2","Cadherin-like. This cadherin domain is usually the most N-terminal copy of the domain.","GO:0007155|cell adhesion;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005911|cell-cell junction;GO:0016021|integral component of membrane;","GO:0005509|calcium ion binding;","K16494","PCDHB; protocadherin beta"]
["ENSRNOG00000047368",8,0.673082149,23,1.479600078,0.45490816,-1.136352781,0.039348444,0.021246777,"down","yes","Acer1","protein_coding","chr9:1793139-1824434:-","gi|157822473|ref|NP_001100345.1|",1454,0,"alkaline ceramidase 1 [Rattus norvegicus]","gi|157822472|ref|NM_001106875.1|",2328,0,"Rattus norvegicus alkaline ceramidase 1 (Acer1), mRNA","Q8R4X1",524,{"v":4e-180,"d":"4.00E-180"},"Alkaline ceramidase 1",".",".",".",".","pfam05875","Ceramidase","Ceramidase. This family consists of several ceramidases. Ceramidases are enzymes involved in regulating cellular levels of ceramides, sphingoid bases, and their phosphates, EC:3.5.1.23.","GO:0006665|sphingolipid metabolic process;GO:0008544|epidermis development;GO:0010446|response to alkaline pH;GO:0019216|regulation of lipid metabolic process;GO:0030148|sphingolipid biosynthetic process;GO:0030154|cell differentiation;GO:0030216|keratinocyte differentiation;GO:0033561|regulation of water loss via skin;GO:0046512|sphingosine biosynthetic process;GO:0046514|ceramide catabolic process;GO:0048733|sebaceous gland development;GO:0071277|cellular response to calcium ion;","GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;","GO:0017040|N-acylsphingosine amidohydrolase activity;GO:0071633|dihydroceramidase activity;GO:0102121|ceramidase activity;","K01441","ACER1_2, ASAH3; alkaline ceramidase [EC:3.5.1.23]"]
["ENSRNOG00000001071",5,0.420676343,17,1.093617449,0.384664988,-1.378325572,0.0393535,0.021246777,"down","yes","AABR07035091.1","protein_coding","chr12:2777231-2777551:-","gi|157824174|ref|NP_001099572.1|",552,{"v":8e-71,"d":"8.00E-71"},"HIG1 domain family member 2A, mitochondrial [Rattus norvegicus]","gi|183986566|gb|BC166544.1|",312,{"v":3e-161,"d":"3.00E-161"},"Rattus norvegicus HIG1 domain family, member 2A, mRNA (cDNA clone MGC:188144 IMAGE:7301761), complete cds","Q9CQJ1",209,{"v":3e-69,"d":"3.00E-69"},"HIG1 domain family member 2A",".",".",".",".","pfam04588","HIG_1_N","Hypoxia induced protein conserved region. This family is found in proteins thought to be involved in the response to hypoxia. Family members mostly come from diverse eukaryotic organisms however eubacterial members have been identified. This region is found at the N-terminus of the member proteins which are predicted to be transmembrane.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000007395",5,0.420676343,17,1.093617449,0.384664988,-1.378325572,0.0393535,0.021246777,"down","yes","Baat","protein_coding","chr5:63850705-63860685:-","gi|148747510|ref|NP_058996.2|",2145,0,"bile acid-CoA:amino acid N-acyltransferase [Rattus norvegicus]","gi|298901365|emb|FQ218773.1|",2705,0,"Rattus norvegicus TL0ABA4YD13 mRNA sequence","Q63276",830,0,"Bile acid-CoA:amino acid N-acyltransferase","CAC3407",130,{"v":4e-31,"d":"4.00E-31"},"COG1073","pfam08840","BAAT_C","BAAT / Acyl-CoA thioester hydrolase C terminal. This catalytic domain is found at the C terminal of acyl-CoA thioester hydrolases and bile acid-CoA:amino acid N-acetyltransferases (BAAT).","GO:0001889|liver development;GO:0002152|bile acid conjugation;GO:0006544|glycine metabolic process;GO:0006631|fatty acid metabolic process;GO:0006637|acyl-CoA metabolic process;GO:0006699|bile acid biosynthetic process;GO:0008206|bile acid metabolic process;GO:0019530|taurine metabolic process;GO:0031100|animal organ regeneration;","GO:0005777|peroxisome;GO:0005829|cytosol;","GO:0003674|molecular_function;GO:0016290|palmitoyl-CoA hydrolase activity;GO:0016410|N-acyltransferase activity;GO:0033882|choloyl-CoA hydrolase activity;GO:0047617|acyl-CoA hydrolase activity;GO:0047963|glycine N-choloyltransferase activity;GO:0052689|carboxylic ester hydrolase activity;GO:0052815|medium-chain acyl-CoA hydrolase activity;GO:0052816|long-chain acyl-CoA hydrolase activity;GO:0052817|very long chain acyl-CoA hydrolase activity;GO:0102991|myristoyl-CoA hydrolase activity;","K00659","BAAT; bile acid-CoA:amino acid N-acyltransferase [EC:2.3.1.65 3.1.2.2]"]
["ENSRNOG00000051306",5,0.420676343,17,1.093617449,0.384664988,-1.378325572,0.0393535,0.021246777,"down","yes","AC096301.1","lncRNA","chr1:240204855-240245055:-",".",".",".",".","gi|672014932|ref|XR_599250.1|",458,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103691362 (LOC103691362), ncRNA",".",".",".",".",".",".",".",".","pfam14538","Raptor_N","Raptor N-terminal CASPase like domain. This domain is found at the N-terminus of the Raptor protein. It has been identified to have a CASPase like structure. It conserves the characteristic cys/his dyad of the caspases suggesting it may have a peptidase activity.",".",".",".",".","."]
["ENSRNOG00000011729",7,0.588946881,21,1.350939202,0.435953653,-1.197753326,0.040041476,0.021581832,"down","yes","Nxf2","protein_coding","chrX:98135950-98157089:-","gi|392343366|ref|XP_002727670.2|",3149,0,"PREDICTED: nuclear RNA export factor 2 isoform X1 [Rattus norvegicus]","gi|672032573|ref|XM_002727624.4|",2100,0,"PREDICTED: Rattus norvegicus nuclear RNA export factor 2 (Nxf2), transcript variant X1, mRNA","Q9GZY0",578,0,"Nuclear RNA export factor 2",".",".",".",".","pfam09162","Tap-RNA_bind","Tap, RNA-binding. Members of this family adopt a structure consisting of an alpha+beta sandwich with an antiparallel beta-sheet, arranged in a 2(beta-alpha-beta) motif. They are mainly found in mRNA export factors, and mediate the sequence nonspecific nuclear export of cellular mRNAs as well as the sequence-specific export of retroviral mRNAs bearing the constitutive transport element.","GO:0008150|biological_process;GO:0016973|poly(A)+ mRNA export from nucleus;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;","GO:0003674|molecular_function;GO:0003723|RNA binding;GO:0003729|mRNA binding;","K14284","NXF, TAP, MEX67; nuclear RNA export factor"]
["ENSRNOG00000014702",7,0.588946881,21,1.350939202,0.435953653,-1.197753326,0.040041476,0.021581832,"down","yes","Elovl2","protein_coding","chr17:23544568-23584848:+","gi|532023594|ref|XP_005355137.1|",1506,0,"PREDICTED: elongation of very long chain fatty acids protein 2 [Microtus ochrogaster]","gi|672081513|ref|XM_006253779.2|",3607,0,"PREDICTED: Rattus norvegicus ELOVL fatty acid elongase 2 (Elovl2), transcript variant X1, mRNA","D4A612",580,0,"Elongation of very long chain fatty acids protein 2",".",".",".",".","pfam01151","ELO","GNS1/SUR4 family. Members of this family are involved in long chain fatty acid elongation systems that produce the 26-carbon precursors for ceramide and sphingolipid synthesis. Predicted to be integral membrane proteins, in eukaryotes they are probably located on the endoplasmic reticulum. Yeast ELO3 affects plasma membrane H+-ATPase activity, and may act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1.","GO:0000038|very long-chain fatty acid metabolic process;GO:0006636|unsaturated fatty acid biosynthetic process;GO:0019367|fatty acid elongation, saturated fatty acid;GO:0030148|sphingolipid biosynthetic process;GO:0034625|fatty acid elongation, monounsaturated fatty acid;GO:0034626|fatty acid elongation, polyunsaturated fatty acid;GO:0042761|very long-chain fatty acid biosynthetic process;","GO:0005783|endoplasmic reticulum;GO:0030176|integral component of endoplasmic reticulum membrane;","GO:0009922|fatty acid elongase activity;GO:0016747|transferase activity, transferring acyl groups other than amino-acyl groups;GO:0102336|3-oxo-arachidoyl-CoA synthase activity;GO:0102337|3-oxo-cerotoyl-CoA synthase activity;GO:0102338|3-oxo-lignoceronyl-CoA synthase activity;GO:0102756|very-long-chain 3-ketoacyl-CoA synthase activity;","K10205","ELOVL2; elongation of very long chain fatty acids protein 2 [EC:2.3.1.199]"]
["ENSRNOG00000017805",7,0.588946881,21,1.350939202,0.435953653,-1.197753326,0.040041476,0.021581832,"down","yes","Duoxa2","protein_coding","chr3:109245476-109248968:+","gi|300794845|ref|NP_001178894.1|",1250,{"v":3e-169,"d":"3.00E-169"},"dual oxidase maturation factor 2 [Rattus norvegicus]","gi|300794844|ref|NM_001191965.1|",963,0,"Rattus norvegicus dual oxidase maturation factor 2 (Duoxa2), mRNA","Q9D311",441,{"v":5e-153,"d":"5.00E-153"},"Dual oxidase maturation factor 2",".",".",".",".","pfam10204","DuoxA","Dual oxidase maturation factor. DuoxA (Dual oxidase maturation factor) is the essential protein necessary for the final release of DUOX2 (an NADPH:O2 oxidoreductase flavoprotein) from the endoplasmic reticulum. Dual oxidases (DUOX1 and DUOX2) constitute the catalytic core of the hydrogen peroxide generator, which generates H2O2 at the apical membrane of thyroid follicular cells, essential for iodination of thyroglobulin by thyroid peroxidases. DuoxA carries five membrane-integral regions including a reverse signal-anchor with external N-terminus (type III) and two N-glycosylation sites. It is conserved from nematodes to humans.","GO:0008104|protein localization;GO:0010729|positive regulation of hydrogen peroxide biosynthetic process;GO:0015031|protein transport;GO:0034613|cellular protein localization;GO:0042743|hydrogen peroxide metabolic process;GO:0050727|regulation of inflammatory response;GO:0051604|protein maturation;GO:2000147|positive regulation of cell motility;GO:2000609|regulation of thyroid hormone generation;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0031252|cell leading edge;GO:0045177|apical part of cell;","GO:0019899|enzyme binding;","K17232","DUOXA2; dual oxidase maturation factor 2"]
["ENSRNOG00000021892",7,0.588946881,21,1.350939202,0.435953653,-1.197753326,0.040041476,0.021581832,"down","yes","Ccdc38","protein_coding","chr7:28059798-28130441:+","gi|109481859|ref|XP_001080322.1|",2946,0,"PREDICTED: coiled-coil domain-containing protein 38 isoform X1 [Rattus norvegicus]","gi|672021556|ref|XM_001080322.3|",2296,0,"PREDICTED: Rattus norvegicus coiled-coil domain containing 38 (Ccdc38), transcript variant X1, mRNA","Q8CDN8",855,0,"Coiled-coil domain-containing protein 38",".",".",".",".","pfam13863","DUF4200","Domain of unknown function (DUF4200). This family is found in eukaryotes. It is a coiled-coil domain of unknwon function.",".","GO:0005813|centrosome;",".",".","."]
["ENSRNOG00000031593",7,0.588946881,21,1.350939202,0.435953653,-1.197753326,0.040041476,0.021581832,"down","yes","Nanos3","protein_coding","chr19:23985504-23988932:+","gi|157786962|ref|NP_001099415.1|",709,{"v":3e-91,"d":"3.00E-91"},"nanos homolog 3 [Rattus norvegicus]","gi|157786961|ref|NM_001105945.1|",738,0,"Rattus norvegicus nanos homolog 3 (Drosophila) (Nanos3), mRNA","P60324",267,{"v":8e-89,"d":"8.00E-89"},"Nanos homolog 3",".",".",".",".","pfam05741","zf-nanos","Nanos RNA binding domain. This family consists of several conserved novel zinc finger domains found in the eukaryotic proteins Nanos and Xcat-2. In Drosophila melanogaster, Nanos functions as a localized determinant of posterior pattern. Nanos RNA is localized to the posterior pole of the maturing egg cell and encodes a protein that emanates from this localized source. Nanos acts as a translational repressor and thereby establishes a gradient of the morphogen Hunchback. Xcat-2 is found in the vegetal cortical region and is inherited by the vegetal blasomeres during development, and is degraded very early in development. The localized and maternally restricted expression of Xcat-2 RNA suggests a role for its protein in setting up regional differences in gene expression that occur early in development.","GO:0006417|regulation of translation;GO:0007281|germ cell development;GO:0007283|spermatogenesis;GO:0017148|negative regulation of translation;GO:0048477|oogenesis;GO:0051726|regulation of cell cycle;GO:1900153|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:2001234|negative regulation of apoptotic signaling pathway;","GO:0000932|P-body;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0010494|cytoplasmic stress granule;GO:0048471|perinuclear region of cytoplasm;","GO:0003723|RNA binding;GO:0003729|mRNA binding;GO:0008270|zinc ion binding;","K18761","NANOS3, NOS3; protein nanos 3"]
["ENSRNOG00000049849",7,0.588946881,21,1.350939202,0.435953653,-1.197753326,0.040041476,0.021581832,"down","yes","ENSRNOG00000049849","protein_coding","chrX:100384225-100414938:+","gi|148691944|gb|EDL23891.1|",1665,0,"cDNA sequence BC031748, partial [Mus musculus]","gi|274320576|ref|NM_146261.2|",2018,0,"Mus musculus family with sequence similarity 199, X-linked (Fam199x), mRNA",".",".",".",".",".",".",".",".","pfam06278","DUF1032","Protein of unknown function (DUF1032). This family consists of several conserved eukaryotic proteins of unknown function.",".",".",".",".","."]
["ENSRNOG00000053606",7,0.588946881,21,1.350939202,0.435953653,-1.197753326,0.040041476,0.021581832,"down","yes","Scarna6","scaRNA","chr9:88450584-88450846:+",".",".",".",".","gi|44891043|gb|AC102630.6|",198,{"v":6E-98,"d":"6.00E-98"},"Mus musculus chromosome 1, clone RP23-473M13, complete sequence",".",".",".",".",".",".",".",".","pfam06956","RtcR","Regulator of RNA terminal phosphate cyclase. RtcR is a sigma54-dependent enhancer binding protein that activates transcription of the rtcBA operon. The product of the rtcA gene is an RNA 3'-terminal phosphate cyclase. This domain is found at the N terminus of the RtcR sequence. RtcR, and other sigma54-dependent activators, contain pfam00158 in the central region of the protein sequence.",".",".",".",".","."]
["ENSRNOG00000013623",6,0.504811612,19,1.222278326,0.413008724,-1.275755838,0.040134552,0.02161702,"down","yes","Amer2","protein_coding","chr15:34524542-34528455:+","gi|564386624|ref|XP_006252228.1|",2251,0,"PREDICTED: APC membrane recruitment protein 2 isoform X3 [Rattus norvegicus]","gi|672078440|ref|XM_006252166.2|",3524,0,"PREDICTED: Rattus norvegicus APC membrane recruitment protein 2 (Amer2), transcript variant X3, mRNA","Q8CCJ4",478,{"v":3E-152,"d":"3.00E-152"},"APC membrane recruitment protein 2",".",".",".",".","pfam09422","WTX","WTX protein. The WTX protein is found to be inactivated in one third of Wilms tumors. The WTX protein is functionally uncharacterized.","GO:0090090|negative regulation of canonical Wnt signaling pathway;","GO:0005886|plasma membrane;","GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;",".","."]
["ENSRNOG00000042716",6,0.504811612,19,1.222278326,0.413008724,-1.275755838,0.040134552,0.02161702,"down","yes","RGD1562699","protein_coding","chr18:57827117-57827989:-","gi|564393782|ref|XP_006254908.1|",365,{"v":2E-41,"d":"2.00E-41"},"PREDICTED: uncharacterized protein LOC291558 isoform X1 [Rattus norvegicus]","gi|672083370|ref|XM_008772122.1|",389,0,"PREDICTED: Rattus norvegicus RGD1562699 (RGD1562699), transcript variant X6, mRNA",".",".",".",".",".",".",".",".","pfam01927","Mut7-C","Mut7-C RNAse domain. RNAse domain of the PIN fold with an inserted Zinc Ribbon at the C terminus.",".",".",".",".","."]
["ENSRNOG00000062486",6,0.504811612,19,1.222278326,0.413008724,-1.275755838,0.040134552,0.02161702,"down","yes","ENSRNOG00000062486","protein_coding","chr18:25931666-25951758:+","gi|953872109|ref|XP_014585880.1|",443,{"v":2e-49,"d":"2.00E-49"},"PREDICTED: signal recognition particle 19 kDa protein [Equus caballus]","gi|298885371|emb|FQ233350.1|",699,0,"Rattus norvegicus TL0AEA62YD18 mRNA sequence","Q9D7A6",160,{"v":3e-47,"d":"3.00E-47"},"Signal recognition particle 19 kDa protein","MTH165",48.5,1e-06,"COG1400","pfam01922","SRP19","SRP19 protein. The signal recognition particle (SRP) binds to the signal peptide of proteins as they are being translated. The binding of the SRP halts translation and the complex is then transported to the endoplasmic reticulum's cytoplasmic surface. The SRP then aids translocation of the protein through the ER membrane. The SRP is a ribonucleoprotein that is composed of a small RNA and several proteins. One of these proteins is the SRP19 protein (Sec65 in yeast).",".",".",".",".","."]
["ENSRNOG00000064177",6,0.504811612,19,1.222278326,0.413008724,-1.275755838,0.040134552,0.02161702,"down","yes","Zbtb41","pseudogene","chr13:51042948-51065768:+","gi|300794074|ref|NP_001178599.1|",4285,0,"zinc finger and BTB domain-containing protein 41 [Rattus norvegicus]","gi|672074056|ref|XM_006249940.2|",2652,0,"PREDICTED: Rattus norvegicus zinc finger and BTB domain containing 41 (Zbtb41), transcript variant X4, mRNA","Q811F1",1608,0,"Zinc finger and BTB domain-containing protein 41",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.",".",".",".",".","."]
["ENSRNOG00000007059",2,0.168270537,10,0.643304382,0.261572192,-1.93471892,0.043972601,0.023477549,"down","yes","Atp1b4","protein_coding","chrX:117057423-117108020:+","gi|564400579|ref|XP_006257555.1|",1601,0,"PREDICTED: protein ATP1B4 isoform X1 [Rattus norvegicus]","gi|12751524|gb|AF158386.2|AF158386",3983,0,"Rattus norvegicus X,K-ATPase beta-m subunit (ATP1B4) mRNA, alternatively spliced product B, complete cds","Q9R193",613,0,"Protein ATP1B4",".",".",".",".","pfam00287","Na_K-ATPase","Sodium / potassium ATPase beta chain.","GO:0006355|regulation of transcription, DNA-templated;GO:0006813|potassium ion transport;GO:0006814|sodium ion transport;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005635|nuclear envelope;GO:0005637|nuclear inner membrane;GO:0005890|sodium:potassium-exchanging ATPase complex;","GO:0005515|protein binding;","K01540","ATP1B, CD298; sodium/potassium-transporting ATPase subunit beta"]
["ENSRNOG00000009197",2,0.168270537,10,0.643304382,0.261572192,-1.93471892,0.043972601,0.023477549,"down","yes","Asb4","protein_coding","chr4:33506992-33544630:+","gi|66730286|ref|NP_001019489.1|",2199,0,"ankyrin repeat and SOCS box protein 4 [Rattus norvegicus]","gi|66730285|ref|NM_001024318.1|",1509,0,"Rattus norvegicus ankyrin repeat and SOCS box-containing 4 (Asb4), mRNA","Q9WV71",835,0,"Ankyrin repeat and SOCS box protein 4","all2748",80.9,{"v":1e-15,"d":"1.00E-15"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0035556|intracellular signal transduction;GO:0051865|protein autoubiquitination;GO:2001214|positive regulation of vasculogenesis;","GO:0031462|Cul2-RING ubiquitin ligase complex;GO:0031466|Cul5-RING ubiquitin ligase complex;","GO:0004842|ubiquitin-protein transferase activity;GO:0019899|enzyme binding;GO:0031625|ubiquitin protein ligase binding;GO:0061630|ubiquitin protein ligase activity;","K10326","ASB4; ankyrin repeat and SOCS box protein 4"]
["ENSRNOG00000010261",2,0.168270537,10,0.643304382,0.261572192,-1.93471892,0.043972601,0.023477549,"down","yes","ENSRNOG00000010261","protein_coding","chr15:24226691-24228561:+","gi|564385932|ref|XP_006251930.1|",1192,{"v":2e-163,"d":"2.00E-163"},"PREDICTED: inactive ribonuclease-like protein 10 isoform X1 [Rattus norvegicus]","gi|672077518|ref|XM_006251868.2|",750,0,"PREDICTED: Rattus norvegicus ribonuclease, RNase A family, 10 (non-active) (Rnase10), transcript variant X1, mRNA","Q5GAM0",389,{"v":5e-136,"d":"5.00E-136"},"Inactive ribonuclease-like protein 10",".",".",".",".","pfam00074","RnaseA","Pancreatic ribonuclease. Ribonucleases. Members include pancreatic RNAase A and angiogenins. Structure is an alpha+beta fold -- long curved beta sheet and three helices.","GO:0003382|epithelial cell morphogenesis;GO:0007338|single fertilization;GO:0008584|male gonad development;GO:0022409|positive regulation of cell-cell adhesion;GO:0034113|heterotypic cell-cell adhesion;GO:0072520|seminiferous tubule development;GO:0080154|regulation of fertilization;GO:1902093|positive regulation of flagellated sperm motility;","GO:0005576|extracellular region;","GO:0003676|nucleic acid binding;",".","."]
["ENSRNOG00000011918",2,0.168270537,10,0.643304382,0.261572192,-1.93471892,0.043972601,0.023477549,"down","yes","Vsx2","protein_coding","chr6:104217230-104240018:+","gi|281306708|ref|NP_001162599.1|",1590,0,"visual system homeobox 2 [Rattus norvegicus]","gi|695917231|ref|NM_001169128.3|",3109,0,"Rattus norvegicus visual system homeobox 2 (Vsx2), mRNA","Q61412",610,0,"Visual system homeobox 2",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007601|visual perception;GO:0008150|biological_process;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0043010|camera-type eye development;GO:0045165|cell fate commitment;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0060040|retinal bipolar neuron differentiation;GO:0060042|retina morphogenesis in camera-type eye;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:1990837|sequence-specific double-stranded DNA binding;","K09336","VSX2, CHX10; visual system homeobox protein 2"]
["ENSRNOG00000020245",2,0.168270537,10,0.643304382,0.261572192,-1.93471892,0.043972601,0.023477549,"down","yes","Syt8","protein_coding","chr1:197590149-197593504:+","gi|149061706|gb|EDM12129.1|",1820,0,"synaptotagmin 8, isoform CRA_b [Rattus norvegicus]","gi|14210275|gb|AF375467.1|AF375467",1173,0,"Rattus norvegicus synaptotagmin 8 mRNA, complete cds","Q925B4",697,0,"Synaptotagmin-8",".",".",".",".","pfam00168","C2","C2 domain.","GO:0006887|exocytosis;GO:0007340|acrosome reaction;GO:0014059|regulation of dopamine secretion;GO:0016192|vesicle-mediated transport;GO:0017156|calcium ion regulated exocytosis;GO:0017158|regulation of calcium ion-dependent exocytosis;GO:0048488|synaptic vesicle endocytosis;GO:0048791|calcium ion-regulated exocytosis of neurotransmitter;GO:0071277|cellular response to calcium ion;","GO:0001669|acrosomal vesicle;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0030672|synaptic vesicle membrane;GO:0031045|dense core granule;GO:0031982|vesicle;GO:0070382|exocytic vesicle;","GO:0000149|SNARE binding;GO:0001786|phosphatidylserine binding;GO:0005509|calcium ion binding;GO:0030276|clathrin binding;GO:0048306|calcium-dependent protein binding;","K19908","SYT8; synaptotagmin-8"]
["ENSRNOG00000021800",2,0.168270537,10,0.643304382,0.261572192,-1.93471892,0.043972601,0.023477549,"down","yes","Zfp541","protein_coding","chr1:76750236-76786567:+","gi|392337463|ref|XP_003753266.1|",6015,0,"PREDICTED: zinc finger protein 541 [Rattus norvegicus]","gi|672035365|ref|XM_008759028.1|",6234,0,"PREDICTED: Rattus norvegicus zinc finger protein 541 (Zfp541), transcript variant X6, mRNA","Q0GGX2",1469,0,"Zinc finger protein 541",".",".",".",".","pfam01448","ELM2","ELM2 domain. The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in a member from Arabidopsis thaliana. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0016575|histone deacetylation;GO:0045892|negative regulation of transcription, DNA-templated;","GO:0000118|histone deacetylase complex;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0003714|transcription corepressor activity;",".","."]
["ENSRNOG00000023493",2,0.168270537,10,0.643304382,0.261572192,-1.93471892,0.043972601,0.023477549,"down","yes","Creb3l4","protein_coding","chr2:175690335-175695932:-","gi|672042937|ref|XP_008759369.1|",1594,0,"PREDICTED: cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2 [Rattus norvegicus]","gi|672042935|ref|XM_006232627.2|",1389,0,"PREDICTED: Rattus norvegicus cAMP responsive element binding protein 3-like 4 (Creb3l4), transcript variant X1, mRNA","Q5UEM7",614,0,"Cyclic AMP-responsive element-binding protein 3-like protein 4",".",".",".",".","pfam00170","bZIP_1","bZIP transcription factor. The Pfam entry includes the basic region and the leucine zipper region.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0007283|spermatogenesis;GO:0008150|biological_process;GO:0030968|endoplasmic reticulum unfolded protein response;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005739|mitochondrion;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;GO:0031965|nuclear membrane;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0035497|cAMP response element binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09048","CREB3; cyclic AMP-responsive element-binding protein 3"]
["ENSRNOG00000026745",2,0.168270537,10,0.643304382,0.261572192,-1.93471892,0.043972601,0.023477549,"down","yes","Acsl6","protein_coding","chr10:38440080-38498757:+","gi|564371650|ref|XP_006246283.1|",4095,0,"PREDICTED: long-chain-fatty-acid--CoA ligase 6 isoform X1 [Rattus norvegicus]","gi|672067212|ref|XM_006246221.2|",2719,0,"PREDICTED: Rattus norvegicus acyl-CoA synthetase long-chain family member 6 (Acsl6), transcript variant X1, mRNA","P33124",1418,0,"Long-chain-fatty-acid--CoA ligase 6","YER015w",310,{"v":5E-91,"d":"5.00E-91"},"COG1022","pfam00501","AMP-binding","AMP-binding enzyme.","GO:0000038|very long-chain fatty acid metabolic process;GO:0001666|response to hypoxia;GO:0001676|long-chain fatty acid metabolic process;GO:0007405|neuroblast proliferation;GO:0007584|response to nutrient;GO:0008610|lipid biosynthetic process;GO:0008654|phospholipid biosynthetic process;GO:0009629|response to gravity;GO:0010747|positive regulation of plasma membrane long-chain fatty acid transport;GO:0010976|positive regulation of neuron projection development;GO:0015908|fatty acid transport;GO:0019432|triglyceride biosynthetic process;GO:0032869|cellular response to insulin stimulus;GO:0035338|long-chain fatty-acyl-CoA biosynthetic process;GO:0048545|response to steroid hormone;GO:0048666|neuron development;","GO:0005634|nucleus;GO:0005741|mitochondrial outer membrane;GO:0005778|peroxisomal membrane;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0004467|long-chain fatty acid-CoA ligase activity;GO:0005524|ATP binding;GO:0019899|enzyme binding;GO:0042803|protein homodimerization activity;GO:0047676|arachidonate-CoA ligase activity;","K01897","ACSL, fadD; long-chain acyl-CoA synthetase [EC:6.2.1.3]"]
["ENSRNOG00000047466",2,0.168270537,10,0.643304382,0.261572192,-1.93471892,0.043972601,0.023477549,"down","yes","Bdnf","protein_coding","chr3:96165042-96215615:+","gi|397174766|ref|NP_036645.2|",1322,{"v":7e-168,"d":"7.00E-168"},"brain-derived neurotrophic factor isoform 2 preproprotein [Rattus norvegicus]","gi|397174765|ref|NM_012513.4|",4291,0,"Rattus norvegicus brain-derived neurotrophic factor (Bdnf), transcript variant 2, mRNA","P23363",497,{"v":4e-163,"d":"4.00E-163"},"Brain-derived neurotrophic factor",".",".",".",".","pfam00243","NGF","Nerve growth factor family.","GO:0001657|ureteric bud development;GO:0001662|behavioral fear response;GO:0001666|response to hypoxia;GO:0002544|chronic inflammatory response;GO:0006120|mitochondrial electron transport, NADH to ubiquinone;GO:0007165|signal transduction;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007214|gamma-aminobutyric acid signaling pathway;GO:0007399|nervous system development;GO:0007406|negative regulation of neuroblast proliferation;GO:0007411|axon guidance;GO:0007412|axon target recognition;GO:0007416|synapse assembly;GO:0007422|peripheral nervous system development;GO:0007568|aging;GO:0007611|learning or memory;GO:0007612|learning;GO:0007613|memory;GO:0007623|circadian rhythm;GO:0007631|feeding behavior;GO:0008038|neuron recognition;GO:0009410|response to xenobiotic stimulus;GO:0009416|response to light stimulus;GO:0009642|response to light intensity;GO:0009725|response to hormone;GO:0010832|negative regulation of myotube differentiation;GO:0010976|positive regulation of neuron projection development;GO:0010996|response to auditory stimulus;GO:0014047|glutamate secretion;GO:0014823|response to activity;GO:0016358|dendrite development;GO:0019222|regulation of metabolic process;GO:0021675|nerve development;GO:0030182|neuron differentiation;GO:0030516|regulation of axon extension;GO:0031099|regeneration;GO:0031667|response to nutrient levels;GO:0032094|response to food;GO:0032229|negative regulation of synaptic transmission, GABAergic;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0033189|response to vitamin A;GO:0034612|response to tumor necrosis factor;GO:0035864|response to potassium ion;GO:0038180|nerve growth factor signaling pathway;GO:0042490|mechanoreceptor differentiation;GO:0042596|fear response;GO:0043066|negative regulation of apoptotic process;GO:0043523|regulation of neuron apoptotic process;GO:0043524|negative regulation of neuron apoptotic process;GO:0045664|regulation of neuron differentiation;GO:0045666|positive regulation of neuron differentiation;GO:0045843|negative regulation of striated muscle tissue development;GO:0046668|regulation of retinal cell programmed cell death;GO:0048148|behavioral response to cocaine;GO:0048167|regulation of synaptic plasticity;GO:0048169|regulation of long-term neuronal synaptic plasticity;GO:0048170|positive regulation of long-term neuronal synaptic plasticity;GO:0048172|regulation of short-term neuronal synaptic plasticity;GO:0048668|collateral sprouting;GO:0048670|regulation of collateral sprouting;GO:0048672|positive regulation of collateral sprouting;GO:0048675|axon extension;GO:0048812|neuron projection morphogenesis;GO:0048839|inner ear development;GO:0050804|modulation of chemical synaptic transmission;GO:0050890|cognition;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051602|response to electrical stimulus;GO:0051965|positive regulation of synapse assembly;GO:0055093|response to hyperoxia;GO:0060079|excitatory postsynaptic potential;GO:0060080|inhibitory postsynaptic potential;GO:0060548|negative regulation of cell death;GO:0061193|taste bud development;GO:0071356|cellular response to tumor necrosis factor;GO:0071874|cellular response to norepinephrine stimulus;GO:0072347|response to anesthetic;GO:0097484|dendrite extension;GO:0099083|retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission;GO:1900122|positive regulation of receptor binding;GO:1901215|negative regulation of neuron death;GO:1902065|response to L-glutamate;GO:1990089|response to nerve growth factor;GO:1990090|cellular response to nerve growth factor stimulus;GO:1990138|neuron projection extension;GO:1990708|conditioned place preference;GO:2000324|positive regulation of glucocorticoid receptor signaling pathway;GO:2001234|negative regulation of apoptotic signaling pathway;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0008021|synaptic vesicle;GO:0016607|nuclear speck;GO:0030061|mitochondrial crista;GO:0030141|secretory granule;GO:0030424|axon;GO:0030425|dendrite;GO:0031410|cytoplasmic vesicle;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0043204|perikaryon;GO:0048471|perinuclear region of cytoplasm;GO:0098794|postsynapse;","GO:0005163|nerve growth factor receptor binding;GO:0005169|neurotrophin TRKB receptor binding;GO:0008083|growth factor activity;","K04355","BDNF; brain-derived neurotrophic factor"]
["ENSRNOG00000061471",2,0.168270537,10,0.643304382,0.261572192,-1.93471892,0.043972601,0.023477549,"down","yes","Gm25744","snoRNA","chr20:3877283-3877346:+",".",".",".",".","gi|46237588|emb|BX883045.1|",64,{"v":3E-24,"d":"3.00E-24"},"Rattus norvegicus chromosome 20, major histocompatibility complex, assembled from 40 BACs, strain Brown Norway (BN/ssNHsd), RT1n haplotype; segment 4/11",".",".",".",".",".",".",".",".","pfam08900","DUF1845","Domain of unknown function (DUF1845). This family of proteins are functionally uncharacterized.",".",".",".",".","."]
["ENSRNOG00000065827",2,0.168270537,10,0.643304382,0.261572192,-1.93471892,0.043972601,0.023477549,"down","yes","ENSRNOG00000065827","protein_coding","chr4:23456894-23501158:-","gi|37654224|gb|AAQ96217.1|",2598,0,"LRRGT00004 [Rattus norvegicus]","gi|672048942|ref|XR_592001.1|",1668,0,"PREDICTED: Rattus norvegicus hypothetical LOC287992 (LOC287992), transcript variant X2, misc_RNA","P03385",52.4,9e-06,"Envelope glycoprotein",".",".",".",".","pfam00429","TLV_coat","ENV polyprotein (coat polyprotein).",".",".",".",".","."]
["ENSRNOG00000066037",2,0.168270537,10,0.643304382,0.261572192,-1.93471892,0.043972601,0.023477549,"down","yes","ENSRNOG00000066037","lncRNA","chr17:73347582-73350610:+",".",".",".",".","gi|49406050|gb|AC084310.16|",78,{"v":5e-31,"d":"5.00E-31"},"Mus musculus chromosome 1, clone RP23-10C10, complete sequence",".",".",".",".",".",".",".",".","pfam00710","Asparaginase","Asparaginase.",".",".",".",".","."]
["ENSRNOG00000066499",2,0.168270537,10,0.643304382,0.261572192,-1.93471892,0.043972601,0.023477549,"down","yes","C1H10orf95","protein_coding","chr1:245210973-245211602:-","gi|672014972|ref|XP_008773074.1|",840,{"v":3e-111,"d":"3.00E-111"},"PREDICTED: uncharacterized protein LOC103691367 [Rattus norvegicus]","gi|672014975|ref|XM_008774854.1|",630,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103691367 (LOC103691367), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam07259","ProSAAS","ProSAAS precursor. This family consists of several mammalian proSAAS precursor proteins. ProSAAS mRNA is expressed primarily in brain and other neuroendocrine tissues (pituitary, adrenal, pancreas); within brain, the mRNA is broadly distributed among neurons. ProSAAS is thought to be an endogenous inhibitor of prohormone convertase 1 may function as a neuropeptide. N-terminal fragments of proSAAS in intracellular Pick Bodies (PBs) may cause a functional disturbance of neurons in Pick's disease.",".",".",".",".","."]
["ENSRNOG00000067375",2,0.168270537,10,0.643304382,0.261572192,-1.93471892,0.043972601,0.023477549,"down","yes","ENSRNOG00000067375","lncRNA","chr8:109030879-109036024:+",".",".",".",".","gi|354796481|gb|JN960982.1|",179,{"v":5e-87,"d":"5.00E-87"},"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Rhoa:tm1a(EUCOMM)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam15122","TMEM206","TMEM206 protein family. The function of this family of transmembrane proteins, TMEM206, has not, as yet, been determined. Members of this family are remain uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are approximately 350 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000068425",2,0.168270537,10,0.643304382,0.261572192,-1.93471892,0.043972601,0.023477549,"down","yes","Zfp551","protein_coding","chr1:72540108-72554071:-","gi|109461011|ref|XP_001063879.1|",3830,0,"PREDICTED: zinc finger protein 551 [Rattus norvegicus]","gi|672034841|ref|XR_590040.1|",2715,0,"PREDICTED: Rattus norvegicus zinc finger protein 551 (Zfp551), transcript variant X3, misc_RNA","B2RUI1",1245,0,"Zinc finger protein 551",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]

{"sheet":"3D_CTX_up","index":5,"n_rows":1540,"n_cols":38,"rows_kept":1540}
["Gene","3D_count","3D_normalize","CTX_count","CTX_normalize","FoldChange","Log2FoldChange","pval","padj","Up/Down","Significant","GeneName","Biotype","Position","NR:Seq-id","NR:Score","NR:Evalue","NR:Description","NT:Seq-id","NT:Score","NT:Evalue","NT:Description","Uniprot:UniProtKB-AC","Uniprot:Score","Uniprot:Evalue","Uniprot:Description","COG:gene","COG:Score","COG:Eval","COG:num","Pfam:pfam_ID","Pfam:pfam_Name","Pfam:pfam_Description","GO:biological_process","GO:cellular_component","GO:molecular_function","KEGG:KO","KEGG:Description"]
["ENSRNOG00000030644",108994,9170.239471,30768,1979.318922,4.633027739,2.21195532,0,0,"up","yes","Mt-nd1","protein_coding","chrMT:2740-3694:+","gi|19577314|emb|CAD21559.1|",989,{"v":2e-130,"d":"2.00E-130"},"NADH dehydrogenase subunit 1, partial (mitochondrion) [Rattus norvegicus]","gi|755572967|gb|KP244683.1|",955,0,"Rattus norvegicus isolate 115 mitochondrion, complete genome","P03889",385,{"v":8e-132,"d":"8.00E-132"},"NADH-ubiquinone oxidoreductase chain 1","RC1230",187,{"v":5e-55,"d":"5.00E-55"},"COG1005","pfam00146","NADHdh","NADH dehydrogenase.","GO:0006120|mitochondrial electron transport, NADH to ubiquinone;GO:0009060|aerobic respiration;GO:0009410|response to xenobiotic stimulus;GO:0014070|response to organic cyclic compound;GO:0032981|mitochondrial respiratory chain complex I assembly;GO:0033194|response to hydroperoxide;","GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0005747|mitochondrial respiratory chain complex I;GO:0030425|dendrite;GO:0031966|mitochondrial membrane;GO:0043025|neuronal cell body;","GO:0003674|molecular_function;GO:0003954|NADH dehydrogenase activity;GO:0008137|NADH dehydrogenase (ubiquinone) activity;","K03878","ND1; NADH-ubiquinone oxidoreductase chain 1 [EC:7.1.1.2]"]
["ENSRNOG00000030371",201303,16936.68198,103741,6673.703988,2.537823376,1.343591666,0,0,"up","yes","Mt-co2","protein_coding","chrMT:7006-7689:+","gi|733386902|ref|YP_009112411.1|",842,{"v":4e-111,"d":"4.00E-111"},"cytochrome c oxidase subunit II (mitochondrion) [Mus spretus]","gi|731446442|gb|KM657953.1|",684,0,"Rattus norvegicus isolate 91 mitochondrion, complete genome","P00406",328,{"v":2e-112,"d":"2.00E-112"},"Cytochrome c oxidase subunit 2","RC0555",132,{"v":2E-35,"d":"2.00E-35"},"COG1622","pfam00116","COX2","Cytochrome C oxidase subunit II, periplasmic domain.","GO:0007595|lactation;GO:0009409|response to cold;GO:0010729|positive regulation of hydrogen peroxide biosynthetic process;GO:0010940|positive regulation of necrotic cell death;GO:0042773|ATP synthesis coupled electron transport;GO:0045907|positive regulation of vasoconstriction;GO:1902600|proton transmembrane transport;GO:2001171|positive regulation of ATP biosynthetic process;","GO:0005575|cellular_component;GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0016021|integral component of membrane;GO:0045277|respiratory chain complex IV;","GO:0003674|molecular_function;GO:0004129|cytochrome-c oxidase activity;GO:0005507|copper ion binding;","K02261","COX2; cytochrome c oxidase subunit 2"]
["ENSRNOG00000029707",107644,9056.656858,40826,2626.354469,3.448375672,1.785916953,0,0,"up","yes","Mt-nd4","protein_coding","chrMT:10160-11537:+","gi|829028|gb|AAD15023.1|",1149,{"v":3e-150,"d":"3.00E-150"},"unknown protein [Rattus norvegicus]","gi|755572967|gb|KP244683.1|",1378,0,"Rattus norvegicus isolate 115 mitochondrion, complete genome","P05508",446,{"v":2e-151,"d":"2.00E-151"},"NADH-ubiquinone oxidoreductase chain 4","BMEI1146",96.7,{"v":1e-20,"d":"1.00E-20"},"COG1008","pfam00361","Oxidored_q1","NADH-Ubiquinone/plastoquinone (complex I), various chains. This family is part of complex I which catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane.","GO:0001666|response to hypoxia;GO:0001701|in utero embryonic development;GO:0006120|mitochondrial electron transport, NADH to ubiquinone;GO:0007568|aging;GO:0009060|aerobic respiration;GO:0015990|electron transport coupled proton transport;GO:0021549|cerebellum development;GO:0032981|mitochondrial respiratory chain complex I assembly;GO:0035094|response to nicotine;GO:0045471|response to ethanol;","GO:0005575|cellular_component;GO:0005743|mitochondrial inner membrane;GO:0005747|mitochondrial respiratory chain complex I;GO:0045271|respiratory chain complex I;","GO:0003674|molecular_function;GO:0003954|NADH dehydrogenase activity;GO:0008137|NADH dehydrogenase (ubiquinone) activity;GO:0048039|ubiquinone binding;","K03881","ND4; NADH-ubiquinone oxidoreductase chain 4 [EC:7.1.1.2]"]
["ENSRNOG00000031033",110241,9275.156151,54705,3519.196621,2.63558907,1.398125449,0,0,"up","yes","Mt-nd2","protein_coding","chrMT:3904-4942:+","gi|110189716|ref|YP_665630.1|",940,{"v":3E-122,"d":"3.00E-122"},"NADH dehydrogenase subunit 2 [Rattus norvegicus]","gi|755572967|gb|KP244683.1|",1039,0,"Rattus norvegicus isolate 115 mitochondrion, complete genome","P11662",366,{"v":1e-123,"d":"1.00E-123"},"NADH-ubiquinone oxidoreductase chain 2","Cj1566c",62,{"v":8e-10,"d":"8.00E-10"},"COG1007","pfam00361","Oxidored_q1","NADH-Ubiquinone/plastoquinone (complex I), various chains. This family is part of complex I which catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane.","GO:0006120|mitochondrial electron transport, NADH to ubiquinone;GO:0008150|biological_process;GO:0032981|mitochondrial respiratory chain complex I assembly;GO:0072593|reactive oxygen species metabolic process;","GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0005747|mitochondrial respiratory chain complex I;GO:0014069|postsynaptic density;","GO:0008137|NADH dehydrogenase (ubiquinone) activity;GO:0019901|protein kinase binding;GO:0035255|ionotropic glutamate receptor binding;","K03879","ND2; NADH-ubiquinone oxidoreductase chain 2 [EC:7.1.1.2]"]
["ENSRNOG00000003897",34640,2914.445706,10315,663.5684699,4.39207985,2.134904284,0,0,"up","yes","Col1a1","protein_coding","chr10:79883622-79900624:+","gi|455975|gb|AAB29425.1|",1373,{"v":8e-171,"d":"8.00E-171"},"type I collagen alpha 1 chain [Mus sp.]","gi|158711703|ref|NM_053304.1|",5825,0,"Rattus norvegicus collagen, type I, alpha 1 (Col1a1), mRNA","P02454",555,{"v":2e-166,"d":"2.00E-166"},"Collagen alpha-1(I) chain",".",".",".",".","pfam01410","COLFI","Fibrillar collagen C-terminal domain. Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1 alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.","GO:0001501|skeletal system development;GO:0001503|ossification;GO:0001568|blood vessel development;GO:0001649|osteoblast differentiation;GO:0001957|intramembranous ossification;GO:0001958|endochondral ossification;GO:0007584|response to nutrient;GO:0007601|visual perception;GO:0007605|sensory perception of sound;GO:0009410|response to xenobiotic stimulus;GO:0009612|response to mechanical stimulus;GO:0010718|positive regulation of epithelial to mesenchymal transition;GO:0010812|negative regulation of cell-substrate adhesion;GO:0015031|protein transport;GO:0030198|extracellular matrix organization;GO:0030199|collagen fibril organization;GO:0030335|positive regulation of cell migration;GO:0031667|response to nutrient levels;GO:0031960|response to corticosteroid;GO:0032355|response to estradiol;GO:0032964|collagen biosynthetic process;GO:0034504|protein localization to nucleus;GO:0034505|tooth mineralization;GO:0038063|collagen-activated tyrosine kinase receptor signaling pathway;GO:0042060|wound healing;GO:0042542|response to hydrogen peroxide;GO:0043434|response to peptide hormone;GO:0043588|skin development;GO:0043589|skin morphogenesis;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0044691|tooth eruption;GO:0045893|positive regulation of transcription, DNA-templated;GO:0048545|response to steroid hormone;GO:0048705|skeletal system morphogenesis;GO:0048706|embryonic skeletal system development;GO:0051591|response to cAMP;GO:0055093|response to hyperoxia;GO:0060325|face morphogenesis;GO:0060346|bone trabecula formation;GO:0060351|cartilage development involved in endochondral bone morphogenesis;GO:0071230|cellular response to amino acid stimulus;GO:0071260|cellular response to mechanical stimulus;GO:0071300|cellular response to retinoic acid;GO:0071306|cellular response to vitamin E;GO:0071356|cellular response to tumor necrosis factor;GO:0071364|cellular response to epidermal growth factor stimulus;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:1902617|response to fluoride;GO:1902618|cellular response to fluoride;","GO:0005576|extracellular region;GO:0005581|collagen trimer;GO:0005584|collagen type I trimer;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0030141|secretory granule;GO:0031012|extracellular matrix;","GO:0002020|protease binding;GO:0005201|extracellular matrix structural constituent;GO:0005515|protein binding;GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0048407|platelet-derived growth factor binding;","K06236","COL1A; collagen type I alpha"]
["ENSRNOG00000029971",27312,2297.902457,10767,692.6458279,3.317572076,1.730127809,0,0,"up","yes","Mt-nd5","protein_coding","chrMT:11736-13565:+","gi|110189725|ref|YP_665639.1|",2147,0,"NADH dehydrogenase subunit 5 [Rattus norvegicus]","gi|755572967|gb|KP244683.1|",1830,0,"Rattus norvegicus isolate 115 mitochondrion, complete genome","P11661",831,0,"NADH-ubiquinone oxidoreductase chain 5","AGc2360",257,{"v":4e-75,"d":"4.00E-75"},"COG1009","pfam00361","Oxidored_q1","NADH-Ubiquinone/plastoquinone (complex I), various chains. This family is part of complex I which catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane.","GO:0001666|response to hypoxia;GO:0006120|mitochondrial electron transport, NADH to ubiquinone;GO:0010243|response to organonitrogen compound;GO:0015990|electron transport coupled proton transport;GO:0032981|mitochondrial respiratory chain complex I assembly;GO:0042542|response to hydrogen peroxide;","GO:0005743|mitochondrial inner membrane;GO:0005747|mitochondrial respiratory chain complex I;GO:0043005|neuron projection;","GO:0003674|molecular_function;GO:0003954|NADH dehydrogenase activity;GO:0008137|NADH dehydrogenase (ubiquinone) activity;","K03883","ND5; NADH-ubiquinone oxidoreductase chain 5 [EC:7.1.1.2]"]
["ENSRNOG00000005825",14678,1234.937473,2629,169.124722,7.3019335,2.86827853,0,0,"up","yes","Lyz2","protein_coding","chr7:52906811-52912106:-","gi|674274809|tpe|CDM98787.1|",488,{"v":8E-55,"d":"8.00E-55"},"TPA: lysozyme f2 [Rattus norvegicus]","gi|349088|gb|L12459.1|RATLYSOZYM",891,0,"Rat lysozyme gene exons 1-4, complete cds","P00697",189,{"v":4E-55,"d":"4.00E-55"},"Lysozyme C-1",".",".",".",".","pfam00062","Lys","C-type lysozyme/alpha-lactalbumin family. Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.","GO:0001895|retina homeostasis;GO:0019835|cytolysis;GO:0031640|killing of cells of other organism;GO:0042742|defense response to bacterium;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;","GO:0000137|Golgi cis cisterna;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005788|endoplasmic reticulum lumen;GO:0005795|Golgi stack;GO:0005902|microvillus;GO:0030140|trans-Golgi network transport vesicle;GO:0030141|secretory granule;GO:0048237|rough endoplasmic reticulum lumen;","GO:0003796|lysozyme activity;GO:0016798|hydrolase activity, acting on glycosyl bonds;GO:0042802|identical protein binding;","K13915","LYZ; lysozyme C [EC:3.2.1.17]"]
["ENSRNOG00000033615",16278,1369.553903,3734,240.2098562,5.701489209,2.511338796,0,0,"up","yes","Mt-nd3","protein_coding","chrMT:9451-9798:+","gi|226453430|ref|YP_002791023.1|",227,{"v":1e-21,"d":"1.00E-21"},"NADH dehydrogenase subunit 3 [Rattus rattus]","gi|755572967|gb|KP244683.1|",348,0,"Rattus norvegicus isolate 115 mitochondrion, complete genome","P03899",91.3,{"v":7e-23,"d":"7.00E-23"},"NADH-ubiquinone oxidoreductase chain 3",".",".",".",".","pfam00507","Oxidored_q4","NADH-ubiquinone/plastoquinone oxidoreductase, chain 3.","GO:0006120|mitochondrial electron transport, NADH to ubiquinone;GO:0006979|response to oxidative stress;GO:0009642|response to light intensity;GO:0009725|response to hormone;GO:0071385|cellular response to glucocorticoid stimulus;","GO:0005575|cellular_component;GO:0005743|mitochondrial inner membrane;GO:0005747|mitochondrial respiratory chain complex I;GO:0030964|NADH dehydrogenase complex;","GO:0003674|molecular_function;GO:0008137|NADH dehydrogenase (ubiquinone) activity;","K03880","ND3; NADH-ubiquinone oxidoreductase chain 3 [EC:7.1.1.2]"]
["ENSRNOG00000062337",8198,689.7409324,264,16.98323568,40.61304603,5.34387133,0,0,"up","yes","ENSRNOG00000062337","rRNA","chr3:2231807-2233678:+","gi|296473176|tpg|DAA15291.1|",778,{"v":2e-96,"d":"2.00E-96"},"TPA: hypothetical protein BOS_23236 [Bos taurus]","gi|380750581|gb|JQ247698.1|",1859,0,"Mus musculus cell-line Neuro-2a 18S ribosomal RNA, complete sequence","Q5DU56",68.6,{"v":1E-10,"d":"1.00E-10"},"Protein NLRC3",".",".",".",".","pfam11847","DUF3367","Domain of unknown function (DUF3367). This domain is functionally uncharacterized. This domain is found in bacteria and archaea. This presumed domain is typically between 667 to 694 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000003357",26719,2248.010243,14347,922.9487966,2.435682511,1.284326092,0,0,"up","yes","Col3a1","protein_coding","chr9:47374593-47410547:+","gi|528758139|gb|EPY77798.1|",1036,{"v":3e-165,"d":"3.00E-165"},"hypothetical protein CB1_001183009 [Camelus ferus]","gi|56711253|ref|NM_032085.1|",4769,0,"Rattus norvegicus collagen, type III, alpha 1 (Col3a1), mRNA","P13941",528,{"v":1e-158,"d":"1.00E-158"},"Collagen alpha-1(III) chain",".",".",".",".","pfam01410","COLFI","Fibrillar collagen C-terminal domain. Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1 alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.","GO:0001501|skeletal system development;GO:0001568|blood vessel development;GO:0001701|in utero embryonic development;GO:0001894|tissue homeostasis;GO:0002062|chondrocyte differentiation;GO:0007160|cell-matrix adhesion;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0007229|integrin-mediated signaling pathway;GO:0007507|heart development;GO:0009314|response to radiation;GO:0009612|response to mechanical stimulus;GO:0010467|gene expression;GO:0018149|peptide cross-linking;GO:0021987|cerebral cortex development;GO:0030198|extracellular matrix organization;GO:0030199|collagen fibril organization;GO:0030324|lung development;GO:0032905|transforming growth factor beta1 production;GO:0034097|response to cytokine;GO:0035025|positive regulation of Rho protein signal transduction;GO:0035264|multicellular organism growth;GO:0035904|aorta development;GO:0036022|limb joint morphogenesis;GO:0042060|wound healing;GO:0043588|skin development;GO:0048144|fibroblast proliferation;GO:0048251|elastic fiber assembly;GO:0048565|digestive tract development;GO:0050777|negative regulation of immune response;GO:0051216|cartilage development;GO:0060350|endochondral bone morphogenesis;GO:0060414|aorta smooth muscle tissue morphogenesis;GO:0071230|cellular response to amino acid stimulus;GO:0097435|supramolecular fiber organization;GO:2001223|negative regulation of neuron migration;","GO:0005581|collagen trimer;GO:0005586|collagen type III trimer;GO:0005615|extracellular space;GO:0031012|extracellular matrix;GO:0062023|collagen-containing extracellular matrix;","GO:0002020|protease binding;GO:0003674|molecular_function;GO:0005178|integrin binding;GO:0005201|extracellular matrix structural constituent;GO:0046332|SMAD binding;GO:0046872|metal ion binding;GO:0048407|platelet-derived growth factor binding;","K19720","COL3A; collagen type III alpha"]
["ENSRNOG00000017414",5779,486.2177175,229,14.73167034,33.0049279,5.044609541,0,0,"up","yes","Irf7","protein_coding","chr1:196367361-196370832:-","gi|76096318|ref|NP_001028863.1|",2147,0,"interferon regulatory factor 7 [Rattus norvegicus]","gi|564331708|ref|XM_006230540.1|",1989,0,"PREDICTED: Rattus norvegicus interferon regulatory factor 7 (Irf7), transcript variant X1, mRNA","P70434",696,0,"Interferon regulatory factor 7",".",".",".",".","pfam10401","IRF-3","Interferon-regulatory factor 3. This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1).  Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.","GO:0002376|immune system process;GO:0002819|regulation of adaptive immune response;GO:0006357|regulation of transcription by RNA polymerase II;GO:0010468|regulation of gene expression;GO:0016064|immunoglobulin mediated immune response;GO:0032481|positive regulation of type I interferon production;GO:0032727|positive regulation of interferon-alpha production;GO:0032728|positive regulation of interferon-beta production;GO:0034124|regulation of MyD88-dependent toll-like receptor signaling pathway;GO:0034127|regulation of MyD88-independent toll-like receptor signaling pathway;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051607|defense response to virus;GO:0060337|type I interferon signaling pathway;GO:0060340|positive regulation of type I interferon-mediated signaling pathway;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987|proximal promoter sequence-specific DNA binding;GO:0003677|DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09447","IRF7; interferon regulatory factor 7"]
["ENSRNOG00000018735",11974,1007.435707,4869,313.2249035,3.216333361,1.685416944,0,0,"up","yes","Cd74","protein_coding","chr18:54256778-54266003:+","gi|6978637|ref|NP_037201.1|",891,{"v":3e-111,"d":"3.00E-111"},"H-2 class II histocompatibility antigen gamma chain [Rattus norvegicus]","gi|672083268|ref|XM_006254761.2|",719,0,"PREDICTED: Rattus norvegicus Cd74 molecule, major histocompatibility complex, class II invariant chain (Cd74), transcript variant X1, mRNA","P10247",343,{"v":3e-110,"d":"3.00E-110"},"H-2 class II histocompatibility antigen gamma chain",".",".",".",".","pfam08831","MHCassoc_trimer","Class II MHC-associated invariant chain trimerization domain. The class II associated invariant chain peptide is required for folding and localisation of MHC class II heterodimers. This domain is involved in trimerization of the ectoderm and interferes with DM/class II binding. The trimeric protein forms a cylindrical shape which is thought to be important for interactions between the invariant chain and class II molecules.","GO:0001516|prostaglandin biosynthetic process;GO:0001934|positive regulation of protein phosphorylation;GO:0001961|positive regulation of cytokine-mediated signaling pathway;GO:0002286|T cell activation involved in immune response;GO:0002606|positive regulation of dendritic cell antigen processing and presentation;GO:0002792|negative regulation of peptide secretion;GO:0002830|positive regulation of type 2 immune response;GO:0002906|negative regulation of mature B cell apoptotic process;GO:0006886|intracellular protein transport;GO:0006952|defense response;GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0008283|cell proliferation;GO:0010628|positive regulation of gene expression;GO:0016064|immunoglobulin mediated immune response;GO:0019882|antigen processing and presentation;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0023019|signal transduction involved in regulation of gene expression;GO:0030336|negative regulation of cell migration;GO:0030890|positive regulation of B cell proliferation;GO:0031394|positive regulation of prostaglandin biosynthetic process;GO:0032722|positive regulation of chemokine production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0033674|positive regulation of kinase activity;GO:0034341|response to interferon-gamma;GO:0035691|macrophage migration inhibitory factor signaling pathway;GO:0043066|negative regulation of apoptotic process;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043410|positive regulation of MAPK cascade;GO:0043518|negative regulation of DNA damage response, signal transduction by p53 class mediator;GO:0045059|positive thymic T cell selection;GO:0045060|negative thymic T cell selection;GO:0045581|negative regulation of T cell differentiation;GO:0045582|positive regulation of T cell differentiation;GO:0045657|positive regulation of monocyte differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0046597|negative regulation of viral entry into host cell;GO:0046598|positive regulation of viral entry into host cell;GO:0048146|positive regulation of fibroblast proliferation;GO:0050729|positive regulation of inflammatory response;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050821|protein stabilization;GO:0051085|chaperone cofactor-dependent protein refolding;GO:0060907|positive regulation of macrophage cytokine production;GO:0065003|protein-containing complex assembly;GO:0070206|protein trimerization;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0090023|positive regulation of neutrophil chemotaxis;GO:1900017|positive regulation of cytokine production involved in inflammatory response;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1902166|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:2000343|positive regulation of chemokine (C-X-C motif) ligand 2 production;GO:2000448|positive regulation of macrophage migration inhibitory factor signaling pathway;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0005770|late endosome;GO:0005771|multivesicular body;GO:0005773|vacuole;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0032991|protein-containing complex;GO:0035692|macrophage migration inhibitory factor receptor complex;GO:0035693|NOS2-CD74 complex;GO:0042613|MHC class II protein complex;","GO:0001540|amyloid-beta binding;GO:0004896|cytokine receptor activity;GO:0019955|cytokine binding;GO:0023026|MHC class II protein complex binding;GO:0035718|macrophage migration inhibitory factor binding;GO:0042289|MHC class II protein binding;GO:0042609|CD4 receptor binding;GO:0042658|MHC class II protein binding, via antigen binding groove;GO:0044183|protein binding involved in protein folding;GO:0050998|nitric-oxide synthase binding;","K06505","CD74, DHLAG; CD74 antigen"]
["ENSRNOG00000007091",8344,702.0246816,2514,161.7267216,4.340808214,2.117963683,0,0,"up","yes","Ly6e","protein_coding","chr7:106935761-106939689:+","gi|564360434|ref|XP_006241819.1|",696,{"v":2e-84,"d":"2.00E-84"},"PREDICTED: lymphocyte antigen 6E isoform X2 [Rattus norvegicus]","gi|672059464|ref|XM_006241757.2|",1766,0,"PREDICTED: Rattus norvegicus lymphocyte antigen 6 complex, locus E (Ly6e), transcript variant X1, mRNA","Q64253",201,{"v":2e-59,"d":"2.00E-59"},"Lymphocyte antigen 6E",".",".",".",".","pfam00021","UPAR_LY6","u-PAR/Ly-6 domain. This extracellular disulphide bond rich domain is related to pfam00087.","GO:0001701|in utero embryonic development;GO:0030325|adrenal gland development;GO:0035265|organ growth;GO:0042415|norepinephrine metabolic process;GO:0046597|negative regulation of viral entry into host cell;GO:0048242|epinephrine secretion;GO:0055010|ventricular cardiac muscle tissue morphogenesis;GO:0095500|acetylcholine receptor signaling pathway;GO:2000272|negative regulation of signaling receptor activity;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0031225|anchored component of membrane;GO:0045202|synapse;","GO:0030550|acetylcholine receptor inhibitor activity;GO:0033130|acetylcholine receptor binding;","K06846","LY6D_E_F_G6_H; lymphocyte antigen 6 complex locus protein D/E/F/G6/H"]
["ENSRNOG00000011292",16101,1354.66196,8391,539.7967068,2.509578038,1.327444809,0,0,"up","yes","Col1a2","protein_coding","chr4:32563381-32598867:+","gi|672048983|ref|XP_008760958.1|",1936,0,"PREDICTED: collagen alpha-2(I) chain isoform X2 [Rattus norvegicus]","gi|672048982|ref|XM_008762736.1|",4599,0,"PREDICTED: Rattus norvegicus collagen, type I, alpha 2 (Col1a2), transcript variant X2, mRNA","P02466",746,0,"Collagen alpha-2(I) chain",".",".",".",".","pfam01410","COLFI","Fibrillar collagen C-terminal domain. Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1 alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.","GO:0001501|skeletal system development;GO:0001568|blood vessel development;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0007266|Rho protein signal transduction;GO:0008217|regulation of blood pressure;GO:0030198|extracellular matrix organization;GO:0030199|collagen fibril organization;GO:0030282|bone mineralization;GO:0032963|collagen metabolic process;GO:0043589|skin morphogenesis;GO:0070208|protein heterotrimerization;GO:0071230|cellular response to amino acid stimulus;GO:0071300|cellular response to retinoic acid;GO:0071310|cellular response to organic substance;GO:0071873|response to norepinephrine;GO:0085029|extracellular matrix assembly;GO:0097067|cellular response to thyroid hormone stimulus;","GO:0005576|extracellular region;GO:0005581|collagen trimer;GO:0005584|collagen type I trimer;GO:0005615|extracellular space;GO:0005783|endoplasmic reticulum;GO:0031012|extracellular matrix;","GO:0002020|protease binding;GO:0003674|molecular_function;GO:0005201|extracellular matrix structural constituent;GO:0030674|protein binding, bridging;GO:0042802|identical protein binding;GO:0046332|SMAD binding;GO:0046872|metal ion binding;GO:0048407|platelet-derived growth factor binding;","K06236","COL1A; collagen type I alpha"]
["ENSRNOG00000029042",6550,551.0860096,1441,92.70016142,5.944822546,2.571633746,0,0,"up","yes","Mt-nd6","protein_coding","chrMT:13543-14061:-","gi|110189726|ref|YP_665640.1|",727,{"v":3e-95,"d":"3.00E-95"},"NADH dehydrogenase subunit 6 [Rattus norvegicus]","gi|755572967|gb|KP244683.1|",519,0,"Rattus norvegicus isolate 115 mitochondrion, complete genome","P03926",284,{"v":1e-96,"d":"1.00E-96"},"NADH-ubiquinone oxidoreductase chain 6",".",".",".",".","pfam00499","Oxidored_q3","NADH-ubiquinone/plastoquinone oxidoreductase chain 6.","GO:0006120|mitochondrial electron transport, NADH to ubiquinone;GO:0032981|mitochondrial respiratory chain complex I assembly;GO:0035094|response to nicotine;GO:0042220|response to cocaine;GO:0042542|response to hydrogen peroxide;","GO:0005575|cellular_component;GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0016021|integral component of membrane;GO:0070469|respiratory chain;","GO:0003674|molecular_function;GO:0008137|NADH dehydrogenase (ubiquinone) activity;","K03884","ND6; NADH-ubiquinone oxidoreductase chain 6 [EC:7.1.1.2]"]
["ENSRNOG00000001959",3881,326.5289776,42,2.701878404,120.8525806,6.91710447,0,0,"up","yes","Mx1","protein_coding","chr11:36799660-36823507:-","gi|71534287|ref|NP_775119.2|",3312,0,"interferon-induced GTP-binding protein Mx1 [Rattus norvegicus]","gi|402692028|ref|NM_173096.3|",3320,0,"Rattus norvegicus myxovirus (influenza virus) resistance 1 (Mx1), transcript variant 1, mRNA","P18588",1270,0,"Interferon-induced GTP-binding protein Mx1","YLL001w",225,{"v":8e-61,"d":"8.00E-61"},"COG0699","pfam01031","Dynamin_M","Dynamin central region. This region lies between the GTPase domain, see pfam00350, and the pleckstrin homology (PH) domain, see pfam00169.","GO:0009615|response to virus;GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0051607|defense response to virus;GO:0070106|interleukin-27-mediated signaling pathway;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005789|endoplasmic reticulum membrane;GO:0005829|cytosol;GO:0005874|microtubule;GO:0016020|membrane;GO:0031965|nuclear membrane;GO:0048471|perinuclear region of cytoplasm;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0008017|microtubule binding;GO:0042802|identical protein binding;","K14754","MX; interferon-induced GTP-binding protein Mx"]
["ENSRNOG00000008816",5695,479.1503549,1386,89.16198732,5.373930857,2.425977759,0,0,"up","yes","Gpnmb","protein_coding","chr4:78010197-78049367:+","gi|62286672|sp|Q6P7C7.1|GPNMB_RAT",2738,0,"RecName: Full=Transmembrane glycoprotein NMB; Flags: Precursor","gi|18959233|ref|NM_133298.1|",1866,0,"Rattus norvegicus glycoprotein nmb (Gpnmb), mRNA","Q6P7C7",1059,0,"Transmembrane glycoprotein NMB",".",".",".",".","pfam00801","PKD","PKD domain. This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.","GO:0001649|osteoblast differentiation;GO:0001818|negative regulation of cytokine production;GO:0001934|positive regulation of protein phosphorylation;GO:0007155|cell adhesion;GO:0007165|signal transduction;GO:0007267|cell-cell signaling;GO:0030282|bone mineralization;GO:0030335|positive regulation of cell migration;GO:0031954|positive regulation of protein autophosphorylation;GO:0032720|negative regulation of tumor necrosis factor production;GO:0034103|regulation of tissue remodeling;GO:0042130|negative regulation of T cell proliferation;GO:0050868|negative regulation of T cell activation;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:1901215|negative regulation of neuron death;GO:2000134|negative regulation of G1/S transition of mitotic cell cycle;","GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;GO:0031410|cytoplasmic vesicle;GO:0031901|early endosome membrane;GO:0033162|melanosome membrane;","GO:0005178|integrin binding;GO:0008201|heparin binding;GO:0045545|syndecan binding;GO:0048018|receptor ligand activity;","K20732","GPNMB; transmembrane glycoprotein NMB"]
["ENSRNOG00000063244",3588,301.8773439,497,31.97222778,9.441861418,3.239071308,0,0,"up","yes","Mpeg1","protein_coding","chr1:209452133-209458855:+","gi|768711622|ref|NP_072139.2|",3691,0,"macrophage-expressed gene 1 protein precursor [Rattus norvegicus]","gi|672039844|ref|XM_008760261.1|",4306,0,"PREDICTED: Rattus norvegicus macrophage expressed 1 (Mpeg1), transcript variant X2, mRNA","Q9WV57",1402,0,"Macrophage-expressed gene 1 protein",".",".",".",".","pfam01823","MACPF","MAC/Perforin domain. The membrane-attack complex (MAC) of the complement system forms transmembrane channels. These channels disrupt the phospholipid bilayer of target cells, leading to cell lysis and death. A number of proteins participate in the assembly of the MAC. Freshly activated C5b binds to C6 to form a C5b-6 complex, then to C7 forming the C5b-7 complex. The C5b-7 complex binds to C8, which is composed of three chains (alpha, beta, and gamma), thus forming the C5b-8 complex. C5b-8 subsequently binds to C9 and acts as a catalyst in the polymerization of C9. Active MAC has a subunit composition of C5b-C6-C7-C8-C9{n}. Perforin is a protein found in cytolytic T-cell and killer cells. In the presence of calcium, perforin polymerizes into transmembrane tubules and is capable of lysing, non-specifically, a variety of target cells. There are a number of regions of similarity in the sequences of complement components C6, C7, C8-alpha, C8-beta, C9 and perforin. The X-ray crystal structure of a MACPF domain reveals that it shares a common fold with bacterial cholesterol dependent cytolysins (pfam01289) such as perfringolysin O. Three key pieces of evidence suggests that MACPF domains and CDCs are homologous: Functional similarity (pore formation), conservation of three glycine residues at a hinge in both families and conservation of a complex core fold.",".",".",".",".","."]
["ENSRNOG00000012660",2608,219.4247806,59,3.795495853,57.81188786,5.85329428,0,0,"up","yes","Postn","protein_coding","chr2:138527696-138559099:+","gi|564336409|ref|XP_006232397.1|",4144,0,"PREDICTED: periostin isoform X1 [Rattus norvegicus]","gi|672042357|ref|XM_006232335.2|",3278,0,"PREDICTED: Rattus norvegicus periostin, osteoblast specific factor (Postn), transcript variant X1, mRNA","Q62009",1575,0,"Periostin","all4647",79,{"v":1e-15,"d":"1.00E-15"},"COG2335","pfam02469","Fasciclin","Fasciclin domain. This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.","GO:0001666|response to hypoxia;GO:0001953|negative regulation of cell-matrix adhesion;GO:0003073|regulation of systemic arterial blood pressure;GO:0007155|cell adhesion;GO:0008593|regulation of Notch signaling pathway;GO:0009612|response to mechanical stimulus;GO:0009888|tissue development;GO:0014850|response to muscle activity;GO:0014911|positive regulation of smooth muscle cell migration;GO:0030198|extracellular matrix organization;GO:0032355|response to estradiol;GO:0042060|wound healing;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0071307|cellular response to vitamin K;GO:0071356|cellular response to tumor necrosis factor;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:1900025|negative regulation of substrate adhesion-dependent cell spreading;GO:1990138|neuron projection extension;GO:1990523|bone regeneration;GO:2000343|positive regulation of chemokine (C-X-C motif) ligand 2 production;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005802|trans-Golgi network;GO:0031012|extracellular matrix;GO:0031594|neuromuscular junction;GO:0062023|collagen-containing extracellular matrix;","GO:0003674|molecular_function;GO:0008201|heparin binding;GO:0046872|metal ion binding;GO:0050839|cell adhesion molecule binding;","K24790","POSTN; periostin"]
["ENSRNOG00000003902",5168,434.8110684,1543,99.26186612,4.380444227,2.131077183,0,0,"up","yes","Fabp6","protein_coding","chr10:28063603-28068282:-","gi|149052320|gb|EDM04137.1|",672,{"v":8e-88,"d":"8.00E-88"},"fatty acid binding protein 6, ileal (gastrotropin) [Rattus norvegicus]","gi|8393345|ref|NM_017098.1|",484,0,"Rattus norvegicus fatty acid binding protein 6 (Fabp6), mRNA","P80020",259,{"v":2E-87,"d":"2.00E-87"},"Gastrotropin",".",".",".",".","pfam14651","Lipocalin_7","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2).","GO:0006869|lipid transport;GO:0008202|steroid metabolic process;","GO:0005829|cytosol;GO:0016020|membrane;","GO:0005504|fatty acid binding;GO:0008289|lipid binding;","K08755","FABP6; fatty acid-binding protein 6, ileal (gastrotropin)"]
["ENSRNOG00000027811",2890,243.1509264,312,20.07109671,12.11448133,3.598660733,0,0,"up","yes","Lilrb4","protein_coding","chr1:69805250-69810660:-","gi|564326168|ref|XP_006228300.1|",1885,0,"PREDICTED: leukocyte immunoglobulin-like receptor, subfamily B, member 4 isoform X2 [Rattus norvegicus]","gi|672034964|ref|XM_006228238.2|",1340,0,"PREDICTED: Rattus norvegicus leukocyte immunoglobulin-like receptor, subfamily B, member 4 (Lilrb4), transcript variant X3, mRNA","Q64281",446,{"v":3E-153,"d":"3.00E-153"},"Leukocyte immunoglobulin-like receptor subfamily B member 4",".",".",".",".","pfam13927","Ig_3","Immunoglobulin domain. This family contains immunoglobulin-like domains.","GO:0002507|tolerance induction;GO:0002669|positive regulation of T cell anergy;GO:0002725|negative regulation of T cell cytokine production;GO:0002774|Fc receptor mediated inhibitory signaling pathway;GO:0031623|receptor internalization;GO:0032682|negative regulation of chemokine production;GO:0032689|negative regulation of interferon-gamma production;GO:0032691|negative regulation of interleukin-1 beta production;GO:0032693|negative regulation of interleukin-10 production;GO:0032703|negative regulation of interleukin-2 production;GO:0032714|negative regulation of interleukin-5 production;GO:0032715|negative regulation of interleukin-6 production;GO:0042130|negative regulation of T cell proliferation;GO:0043124|negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043378|positive regulation of CD8-positive, alpha-beta T cell differentiation;GO:0043409|negative regulation of MAPK cascade;GO:0045584|negative regulation of cytotoxic T cell differentiation;GO:0045591|positive regulation of regulatory T cell differentiation;GO:0045671|negative regulation of osteoclast differentiation;GO:0046007|negative regulation of activated T cell proliferation;GO:0050860|negative regulation of T cell receptor signaling pathway;GO:0061099|negative regulation of protein tyrosine kinase activity;GO:0071659|negative regulation of IP-10 production;GO:0140105|interleukin-10-mediated signaling pathway;GO:1900016|negative regulation of cytokine production involved in inflammatory response;GO:1900181|negative regulation of protein localization to nucleus;GO:1902894|negative regulation of pri-miRNA transcription by RNA polymerase II;GO:2000272|negative regulation of signaling receptor activity;GO:2000524|negative regulation of T cell costimulation;","GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0019903|protein phosphatase binding;GO:0030293|transmembrane receptor protein tyrosine kinase inhibitor activity;GO:0030547|receptor inhibitor activity;","K06512","LILR, CD85; leukocyte immunoglobulin-like receptor"]
["ENSRNOG00000020206",12543,1055.308675,7681,494.1220957,2.135724518,1.094725569,0,0,"up","yes","Ctsd","protein_coding","chr1:197527467-197539488:-","gi|42476045|ref|NP_599161.2|",1940,0,"cathepsin D precursor [Rattus norvegicus]","gi|42476044|ref|NM_134334.2|",1965,0,"Rattus norvegicus cathepsin D (Ctsd), mRNA","P24268",748,0,"Cathepsin D",".",".",".",".","pfam00026","Asp","Eukaryotic aspartyl protease. Aspartyl (acid) proteases include pepsins, cathepsins, and renins. Two-domain structure, probably arising from ancestral duplication. This family does not include the retroviral nor retrotransposon proteases (pfam00077), which are much smaller and appear to be homologous to a single domain of the eukaryotic asp proteases.","GO:0000045|autophagosome assembly;GO:0006508|proteolysis;GO:0031667|response to nutrient levels;GO:0042159|lipoprotein catabolic process;GO:0043065|positive regulation of apoptotic process;GO:0043280|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0070201|regulation of establishment of protein localization;","GO:0005615|extracellular space;GO:0005764|lysosome;GO:0005765|lysosomal membrane;GO:0010008|endosome membrane;GO:0042470|melanosome;GO:0045121|membrane raft;","GO:0004175|endopeptidase activity;GO:0004190|aspartic-type endopeptidase activity;GO:0008233|peptidase activity;GO:0016787|hydrolase activity;GO:0042277|peptide binding;GO:0070001|aspartic-type peptidase activity;","K01379","CTSD; cathepsin D [EC:3.4.23.5]"]
["ENSRNOG00000026605",3857,324.5097312,892,57.38275086,5.655179062,2.499572705,0,0,"up","yes","Ifi27l2b","protein_coding","chr6:122598872-122600360:-","gi|12845165|dbj|BAB26643.1|",159,{"v":2e-11,"d":"2.00E-11"},"unnamed protein product [Mus musculus]","gi|402747131|ref|NM_206846.2|",451,0,"Rattus norvegicus interferon, alpha-inducible protein 27 like 2B (Ifi27l2b), mRNA",".",".",".",".",".",".",".",".","pfam06140","Ifi-6-16","Interferon-induced 6-16 family.","GO:0006915|apoptotic process;GO:0007568|aging;GO:0009615|response to virus;GO:0097190|apoptotic signaling pathway;","GO:0005739|mitochondrion;GO:0016021|integral component of membrane;GO:0031966|mitochondrial membrane;",".",".","."]
["ENSRNOG00000001153",3405,286.4805897,717,46.12492418,6.210971505,2.634818949,0,0,"up","yes","Pla2g1b","protein_coding","chr12:41142200-41153226:-","gi|672072943|ref|XP_008767444.1|",629,{"v":2E-78,"d":"2.00E-78"},"PREDICTED: phospholipase A2 isoform X1 [Rattus norvegicus]","gi|672072942|ref|XM_008769222.1|",650,0,"PREDICTED: Rattus norvegicus phospholipase A2, group IB, pancreas (Pla2g1b), transcript variant X1, mRNA","P04055",244,{"v":6E-79,"d":"6.00E-79"},"Phospholipase A2",".",".",".",".","pfam00068","Phospholip_A2_1","Phospholipase A2. Phospholipase A2 releases fatty acids from the second carbon group of glycerol. Perhaps the best known members are secreted snake venoms, but also found in secreted pancreatic and membrane-associated forms. Structure is all-alpha, with two core disulfide-linked helices and a calcium-binding loop. This alignment represents the major family of PLA2s. A second minor family, defined by the honeybee venom PLA2 PDB:1POC and related sequences from Gila monsters (Heloderma), is not recognized. This minor family conserves the core helix pair but is substantially different elsewhere. The PROSITE pattern PA2_HIS, specific to the first core helix, recognizes both families.","GO:0002227|innate immune response in mucosa;GO:0002446|neutrophil mediated immunity;GO:0006633|fatty acid biosynthetic process;GO:0006644|phospholipid metabolic process;GO:0008284|positive regulation of cell proliferation;GO:0010524|positive regulation of calcium ion transport into cytosol;GO:0016042|lipid catabolic process;GO:0019370|leukotriene biosynthetic process;GO:0019731|antibacterial humoral response;GO:0030593|neutrophil chemotaxis;GO:0032757|positive regulation of interleukin-8 production;GO:0032869|cellular response to insulin stimulus;GO:0035556|intracellular signal transduction;GO:0043406|positive regulation of MAP kinase activity;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046324|regulation of glucose import;GO:0046470|phosphatidylcholine metabolic process;GO:0046471|phosphatidylglycerol metabolic process;GO:0048146|positive regulation of fibroblast proliferation;GO:0050482|arachidonic acid secretion;GO:0050778|positive regulation of immune response;GO:0050830|defense response to Gram-positive bacterium;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:1904635|positive regulation of glomerular visceral epithelial cell apoptotic process;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0009986|cell surface;GO:0030141|secretory granule;","GO:0004623|phospholipase A2 activity;GO:0005102|signaling receptor binding;GO:0005509|calcium ion binding;GO:0032052|bile acid binding;GO:0047498|calcium-dependent phospholipase A2 activity;","K01047","PLA2G, SPLA2; secretory phospholipase A2 [EC:3.1.1.4]"]
["ENSRNOG00000029996",3070,258.2952747,534,34.35245399,7.518975932,2.910536183,0,0,"up","yes","AABR07054368.1","protein_coding","chr3:143138640-143140802:-","gi|62896605|dbj|BAD96243.1|",1815,0,"eukaryotic translation elongation factor 1 alpha 1 variant [Homo sapiens]","gi|672047760|ref|XR_591795.1|",1138,0,"PREDICTED: Rattus norvegicus elongation factor 1-alpha 1 pseudogene (LOC103691939), misc_RNA","P62630",702,0,"Elongation factor 1-alpha 1","SPCC794.09c",573,0,"COG5256","pfam03143","GTP_EFTU_D3","Elongation factor Tu C-terminal domain. Elongation factor Tu consists of three structural domains, this is the third domain. This domain adopts a beta barrel structure. This the third domain is involved in binding to both charged tRNA and binding to EF-Ts pfam00889.",".",".",".",".","."]
["ENSRNOG00000022839",2062,173.4869239,57,3.666834977,47.31244385,5.564147778,0,0,"up","yes","Ifit3","protein_coding","chr1:232114166-232119307:+","gi|56090427|ref|NP_001007695.1|",2187,0,"interferon-induced protein with tetratricopeptide repeats 3 [Rattus norvegicus]","gi|56090426|ref|NM_001007694.1|",1989,0,"Rattus norvegicus interferon-induced protein with tetratricopeptide repeats 3 (Ifit3), mRNA","Q64345",688,0,"Interferon-induced protein with tetratricopeptide repeats 3",".",".",".",".","pfam13424","TPR_12","Tetratricopeptide repeat.","GO:0008285|negative regulation of cell proliferation;GO:0009615|response to virus;GO:0009617|response to bacterium;GO:0035457|cellular response to interferon-alpha;GO:0035458|cellular response to interferon-beta;GO:0035634|response to stilbenoid;GO:0043066|negative regulation of apoptotic process;GO:0051607|defense response to virus;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;","GO:0003723|RNA binding;GO:0042802|identical protein binding;","K24849","IFIT3; interferon-induced protein with tetratricopeptide repeats 3"]
["ENSRNOG00000061813",1903,160.1094162,82,5.275095931,30.35194399,4.923717016,0,0,"up","yes","Ly6c","protein_coding","chr7:106959511-106963329:-","gi|9910398|ref|NP_064488.1|",500,{"v":1e-57,"d":"1.00E-57"},"Ly6-C antigen precursor [Rattus norvegicus]","gi|672075999|ref|XM_003751343.2|",727,0,"PREDICTED: Rattus norvegicus lymphocyte antigen 6B-like (LOC100911104), mRNA","Q63317",129,{"v":4e-34,"d":"4.00E-34"},"Lymphocyte antigen 6B",".",".",".",".","pfam00021","UPAR_LY6","u-PAR/Ly-6 domain. This extracellular disulphide bond rich domain is related to pfam00087.","GO:0095500|acetylcholine receptor signaling pathway;GO:2000272|negative regulation of signaling receptor activity;","GO:0005886|plasma membrane;GO:0045202|synapse;","GO:0030550|acetylcholine receptor inhibitor activity;GO:0033130|acetylcholine receptor binding;","K06846","LY6D_E_F_G6_H; lymphocyte antigen 6 complex locus protein D/E/F/G6/H"]
["ENSRNOG00000051235",3744,315.0024458,1148,73.85134304,4.265358392,2.092666968,0,0,"up","yes","Cfb","protein_coding","chr20:3951474-3976505:+","gi|47575877|ref|NP_757376.2|",3941,0,"complement C2 precursor [Rattus norvegicus]","gi|47575876|ref|NM_172222.2|",1879,0,"Rattus norvegicus complement component 2 (C2), mRNA","P21180",1314,0,"Complement C2",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0006508|proteolysis;GO:0006956|complement activation;GO:0006958|complement activation, classical pathway;GO:0007584|response to nutrient;GO:0045087|innate immune response;GO:2000427|positive regulation of apoptotic cell clearance;","GO:0005575|cellular_component;GO:0005576|extracellular region;","GO:0004252|serine-type endopeptidase activity;GO:0005515|protein binding;","K01332","C2; complement component 2 [EC:3.4.21.43]"]
["ENSRNOG00000009263",6252,526.0136996,3220,207.144011,2.539362336,1.344466265,0,0,"up","yes","Ifi27","protein_coding","chr6:122590472-122779294:+","gi|149025408|gb|EDL81775.1|",493,{"v":3e-58,"d":"3.00E-58"},"rCG20848, isoform CRA_b [Rattus norvegicus]","gi|298888013|emb|FQ233730.1|",827,0,"Rattus norvegicus TL0AEA60YK12 mRNA sequence","Q8R412",78.2,{"v":5e-17,"d":"5.00E-17"},"Interferon alpha-inducible protein 27-like protein 2A",".",".",".",".","pfam06140","Ifi-6-16","Interferon-induced 6-16 family.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006915|apoptotic process;GO:0032355|response to estradiol;GO:0034097|response to cytokine;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0044827|modulation by host of viral genome replication;GO:0045087|innate immune response;GO:0046825|regulation of protein export from nucleus;GO:0051607|defense response to virus;GO:0060135|maternal process involved in female pregnancy;GO:0060337|type I interferon signaling pathway;GO:0070936|protein K48-linked ubiquitination;GO:0097190|apoptotic signaling pathway;GO:0097191|extrinsic apoptotic signaling pathway;","GO:0005575|cellular_component;GO:0005635|nuclear envelope;GO:0005637|nuclear inner membrane;GO:0005739|mitochondrion;GO:0016021|integral component of membrane;GO:0031966|mitochondrial membrane;","GO:0003674|molecular_function;GO:0005521|lamin binding;GO:0042802|identical protein binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;",".","."]
["ENSRNOG00000055934",2888,242.9826559,739,47.54019382,5.111099395,2.353633647,0,0,"up","yes","Dmkn","protein_coding","chr1:86014188-86030006:+","gi|290563809|ref|NP_001166828.1|",1739,0,"dermokine precursor [Rattus norvegicus]","gi|290563808|ref|NM_001173357.1|",1667,0,"Rattus norvegicus dermokine (Dmkn), mRNA","Q6P253",313,{"v":1E-97,"d":"1.00E-97"},"Dermokine",".",".",".",".","pfam04625","DEC-1_N","DEC-1 protein, N-terminal region. The defective chorion-1 gene (dec-1) in Drosophila encodes follicle cell proteins necessary for proper eggshell assembly. Multiple products of the dec-1 gene are formed by alternative RNA splicing and proteolytic processing. Cleavage products include S80 (80 kDa) which is incorporated into the eggshell, and further proteolysis of S80 gives S60 (60 kDa).","GO:1903575|cornified envelope assembly;","GO:0005615|extracellular space;",".",".","."]
["ENSRNOG00000036604",1838,154.6406238,187,12.02979194,12.85480452,3.684235766,0,0,"up","yes","Ifit2","protein_coding","chr1:232102570-232108635:+","gi|67078506|ref|NP_001019924.1|",2343,0,"interferon-induced protein with tetratricopeptide repeats 2 [Rattus norvegicus]","gi|67078505|ref|NM_001024753.1|",3402,0,"Rattus norvegicus interferon-induced protein with tetratricopeptide repeats 2 (Ifit2), mRNA","Q64112",713,0,"Interferon-induced protein with tetratricopeptide repeats 2",".",".",".",".","pfam13424","TPR_12","Tetratricopeptide repeat.","GO:0009615|response to virus;GO:0032091|negative regulation of protein binding;GO:0035457|cellular response to interferon-alpha;GO:0043065|positive regulation of apoptotic process;GO:0051607|defense response to virus;","GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;","GO:0003723|RNA binding;","K24848","IFIT2; interferon-induced protein with tetratricopeptide repeats 2"]
["ENSRNOG00000001963",1525,128.3062847,42,2.701878404,47.48780867,5.569485279,0,0,"up","yes","Mx2","protein_coding","chr11:36906111-36930342:+","gi|71534283|ref|NP_599177.2|",3379,0,"interferon-induced GTP-binding protein Mx2 [Rattus norvegicus]","gi|56722|emb|X52712.1|",2150,0,"Rat mRNA for Mx2 protein","P18590",1302,0,"Interferon-induced GTP-binding protein Mx3","YKR001c",231,{"v":4e-64,"d":"4.00E-64"},"COG0699","pfam01031","Dynamin_M","Dynamin central region. This region lies between the GTPase domain, see pfam00350, and the pleckstrin homology (PH) domain, see pfam00169.","GO:0009615|response to virus;GO:0016197|endosomal transport;GO:0034340|response to type I interferon;GO:0035455|response to interferon-alpha;GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0046822|regulation of nucleocytoplasmic transport;GO:0051607|defense response to virus;GO:0051726|regulation of cell cycle;GO:0071357|cellular response to type I interferon;GO:1901253|negative regulation of intracellular transport of viral material;","GO:0005634|nucleus;GO:0005643|nuclear pore;GO:0005737|cytoplasm;GO:0005874|microtubule;GO:0016020|membrane;GO:0070382|exocytic vesicle;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0008017|microtubule binding;","K14754","MX; interferon-induced GTP-binding protein Mx"]
["ENSRNOG00000003217",4797,403.5968837,2192,141.0123205,2.862139154,1.517093816,0,0,"up","yes","Lgals3bp","protein_coding","chr10:103619908-103629256:-","gi|149054938|gb|EDM06755.1|",2999,0,"lectin, galactoside-binding, soluble, 3 binding protein, isoform CRA_a [Rattus norvegicus]","gi|20806134|ref|NM_139096.1|",2090,0,"Rattus norvegicus lectin, galactoside-binding, soluble, 3 binding protein (Lgals3bp), mRNA","O70513",1158,0,"Galectin-3-binding protein",".",".",".",".","pfam00530","SRCR","Scavenger receptor cysteine-rich domain. These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.","GO:0006897|endocytosis;GO:0007155|cell adhesion;","GO:0005615|extracellular space;GO:0016020|membrane;","GO:0005044|scavenger receptor activity;","K17300","LGALS3BP; galectin-3-binding protein"]
["ENSRNOG00000021157",3467,291.6969764,1233,79.31943028,3.67749712,1.878724212,0,0,"up","yes","Ctss","protein_coding","chr2:183086437-183114483:+","gi|74214026|dbj|BAE29430.1|",1648,0,"unnamed protein product [Mus musculus]","gi|298901396|emb|FQ218804.1|",1393,0,"Rattus norvegicus TL0ABA49YN06 mRNA sequence","O70370",629,0,"Cathepsin S","AF1946_2",91.7,{"v":7e-20,"d":"7.00E-20"},"COG4870","pfam00112","Peptidase_C1","Papain family cysteine protease.","GO:0001656|metanephros development;GO:0002250|adaptive immune response;GO:0006508|proteolysis;GO:0006955|immune response;GO:0010447|response to acidic pH;GO:0016485|protein processing;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030574|collagen catabolic process;GO:0034769|basement membrane disassembly;GO:0045453|bone resorption;GO:0048002|antigen processing and presentation of peptide antigen;GO:0050729|positive regulation of inflammatory response;GO:0051603|proteolysis involved in cellular protein catabolic process;GO:0051930|regulation of sensory perception of pain;GO:0097067|cellular response to thyroid hormone stimulus;GO:2001259|positive regulation of cation channel activity;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005764|lysosome;GO:0005770|late endosome;GO:0009986|cell surface;GO:0016020|membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0045335|phagocytic vesicle;","GO:0001968|fibronectin binding;GO:0004197|cysteine-type endopeptidase activity;GO:0004252|serine-type endopeptidase activity;GO:0005518|collagen binding;GO:0008233|peptidase activity;GO:0008234|cysteine-type peptidase activity;GO:0043236|laminin binding;GO:0043394|proteoglycan binding;","K01368","CTSS; cathepsin S [EC:3.4.22.27]"]
["ENSRNOG00000019412",5705,479.9917076,3062,196.9798017,2.436755969,1.284961778,0,0,"up","yes","Rhbg","protein_coding","chr2:173704562-173717321:-","gi|34013522|ref|NP_898877.1|",1531,0,"ammonium transporter Rh type B precursor [Rattus norvegicus]","gi|51259432|gb|BC079365.1|",1238,0,"Rattus norvegicus Rh family, B glycoprotein, mRNA (cDNA clone MGC:94848 IMAGE:7109321), complete cds","Q68FT6",593,0,"Ammonium transporter Rh type B",".",".",".",".","pfam00909","Ammonium_transp","Ammonium Transporter Family.","GO:0008150|biological_process;GO:0015696|ammonium transport;GO:0070634|transepithelial ammonium transport;GO:0072488|ammonium transmembrane transport;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0014731|spectrin-associated cytoskeleton;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0030659|cytoplasmic vesicle membrane;GO:0046658|anchored component of plasma membrane;","GO:0003674|molecular_function;GO:0008519|ammonium transmembrane transporter activity;GO:0030506|ankyrin binding;","K06580","SLC42A, RHAG, RHBG, RHCG, CD241; ammonium transporter Rh"]
["ENSRNOG00000021243",1375,115.6859944,62,3.988487167,29.00498097,4.858228768,0,0,"up","yes","Siglec1","protein_coding","chr3:118287988-118306850:-","gi|564343027|ref|XP_006235086.1|",8540,0,"PREDICTED: sialoadhesin isoform X1 [Rattus norvegicus]","gi|672046902|ref|XM_006235024.2|",6172,0,"PREDICTED: Rattus norvegicus sialic acid binding Ig-like lectin 1, sialoadhesin (Siglec1), transcript variant X1, mRNA","Q62230",2862,0,"Sialoadhesin",".",".",".",".","pfam08205","C2-set_2","CD80-like C2-set immunoglobulin domain. These domains belong to the immunoglobulin superfamily.","GO:0046718|viral entry into host cell;GO:0050765|negative regulation of phagocytosis;GO:0070234|positive regulation of T cell apoptotic process;GO:0072583|clathrin-dependent endocytosis;GO:0075512|clathrin-dependent endocytosis of virus by host cell;GO:2001238|positive regulation of extrinsic apoptotic signaling pathway;","GO:0005769|early endosome;GO:0005770|late endosome;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030139|endocytic vesicle;","GO:0030246|carbohydrate binding;GO:0046790|virion binding;","K06548","SN, SIGLEC1, CD169; sialoadhesin"]
["ENSRNOG00000000777",2000,168.2705373,381,24.50989695,6.865411864,2.779346272,0,0,"up","yes","RT1-S3","protein_coding","chr20:2670709-2675411:+","gi|261878529|ref|NP_001008886.2|",1806,0,"RT1 class Ib, locus S3 precursor [Rattus norvegicus]","gi|261878528|ref|NM_001008886.2|",2682,0,"Rattus norvegicus RT1 class Ib, locus S3 (RT1-S3), mRNA","P06339",544,0,"H-2 class I histocompatibility antigen, D-37 alpha chain",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.","GO:0001815|positive regulation of antibody-dependent cellular cytotoxicity;GO:0001916|positive regulation of T cell mediated cytotoxicity;GO:0002250|adaptive immune response;GO:0002476|antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002477|antigen processing and presentation of exogenous peptide antigen via MHC class Ib;GO:0002486|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0002489|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent;GO:0002519|natural killer cell tolerance induction;GO:0002639|positive regulation of immunoglobulin production;GO:0002715|regulation of natural killer cell mediated immunity;GO:0002717|positive regulation of natural killer cell mediated immunity;GO:0002729|positive regulation of natural killer cell cytokine production;GO:0006955|immune response;GO:0019731|antibacterial humoral response;GO:0032736|positive regulation of interleukin-13 production;GO:0032753|positive regulation of interleukin-4 production;GO:0032759|positive regulation of TRAIL production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032819|positive regulation of natural killer cell proliferation;GO:0036037|CD8-positive, alpha-beta T cell activation;GO:0042270|protection from natural killer cell mediated cytotoxicity;GO:0045953|negative regulation of natural killer cell mediated cytotoxicity;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;GO:0048839|inner ear development;GO:0050830|defense response to Gram-positive bacterium;GO:2000566|positive regulation of CD8-positive, alpha-beta T cell proliferation;GO:2001187|positive regulation of CD8-positive, alpha-beta T cell activation;","GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0032398|MHC class Ib protein complex;GO:0042612|MHC class I protein complex;","GO:0005102|signaling receptor binding;GO:0030881|beta-2-microglobulin binding;GO:0042288|MHC class I protein binding;GO:0042605|peptide antigen binding;GO:0042608|T cell receptor binding;GO:0046703|natural killer cell lectin-like receptor binding;","K06751","MHC1; MHC class I antigen"]
["ENSRNOG00000032825",2482,208.8237368,758,48.76247214,4.28246821,2.098442537,0,0,"up","yes","Rpl30","protein_coding","chr10:36831500-36831990:-","gi|664777237|ref|XP_008507911.1|",610,{"v":5e-78,"d":"5.00E-78"},"PREDICTED: 60S ribosomal protein L30-like [Equus przewalskii]","gi|672024756|ref|XM_003752328.3|",487,0,"PREDICTED: Rattus norvegicus ribosomal protein L30-like (LOC100362027), mRNA","P62890",236,{"v":1E-78,"d":"1.00E-78"},"60S ribosomal protein L30","SPAC9G1.03c",153,{"v":5e-47,"d":"5.00E-47"},"COG1911","pfam01248","Ribosomal_L7Ae","Ribosomal protein L7Ae/L30e/S12e/Gadd45 family. This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118.",".","GO:0005829|cytosol;",".","K02908","RP-L30e, RPL30; large subunit ribosomal protein L30e"]
["ENSRNOG00000065394",1693,142.4410098,294,18.91314883,7.531321787,2.912903088,0,0,"up","yes","ENSRNOG00000065394","lncRNA","chr1:31564-36478:+","gi|149066342|gb|EDM16215.1|",297,{"v":1E-26,"d":"1.00E-26"},"rCG59713 [Rattus norvegicus]","gi|14389324|gb|AC087775.2|",859,0,"Rattus norvegicus strain Brown Norway clone RP31-464J4, complete sequence","Q4VAE3",117,{"v":1E-27,"d":"1.00E-27"},"Transmembrane protein 65",".",".",".",".","pfam10507","DUF2453","Protein of unknown function (DUF2453). Some members of this family are purported to contain GAF domains but this could not be confirmed. The function is not known. It is likely to be a transmembrane protein.",".",".",".",".","."]
["ENSRNOG00000010319",1822,153.2944595,365,23.48060994,6.528555258,2.706763765,0,0,"up","yes","Lcp1","protein_coding","chr15:50488149-50544680:+","gi|564387027|ref|XP_006252380.1|",3378,0,"PREDICTED: plastin-2 isoform X2 [Rattus norvegicus]","gi|672078709|ref|XM_006252320.2|",3387,0,"PREDICTED: Rattus norvegicus lymphocyte cytosolic protein 1 (Lcp1), transcript variant X3, mRNA","Q61233",1286,0,"Plastin-2","SPBC1778.06c",441,{"v":9e-139,"d":"9.00E-139"},"COG5069","pfam00307","CH","Calponin homology (CH) domain. The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.","GO:0002286|T cell activation involved in immune response;GO:0010737|protein kinase A signaling;GO:0016477|cell migration;GO:0022617|extracellular matrix disassembly;GO:0031100|animal organ regeneration;GO:0033157|regulation of intracellular protein transport;GO:0051017|actin filament bundle assembly;GO:0051639|actin filament network formation;GO:0071803|positive regulation of podosome assembly;","GO:0001725|stress fiber;GO:0001726|ruffle;GO:0001891|phagocytic cup;GO:0002102|podosome;GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0005925|focal adhesion;GO:0015629|actin cytoskeleton;GO:0030175|filopodium;GO:0032432|actin filament bundle;GO:0048471|perinuclear region of cytoplasm;","GO:0003674|molecular_function;GO:0005178|integrin binding;GO:0005509|calcium ion binding;GO:0042802|identical protein binding;GO:0051015|actin filament binding;GO:0051020|GTPase binding;","K17276","LCP1, PLS2; plastin-2"]
["ENSRNOG00000032596",1858,156.3233291,397,25.53918396,6.120921068,2.613748764,0,0,"up","yes","RT1-T24-1","protein_coding","chr20:2718279-2776154:+","gi|57012364|ref|NP_001008858.1|",1733,0,"RT1 class I, locus T24, gene 1 [Rattus norvegicus]","gi|672085680|ref|XM_008772730.1|",1440,0,"PREDICTED: Rattus norvegicus RT1 class I, locus T24, gene 1 (RT1-T24-1), transcript variant X1, mRNA","P16391",342,{"v":1E-107,"d":"1.00E-107"},"RT1 class I histocompatibility antigen, AA alpha chain",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.","GO:0001916|positive regulation of T cell mediated cytotoxicity;GO:0002476|antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002486|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0006955|immune response;","GO:0005615|extracellular space;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0005102|signaling receptor binding;GO:0042605|peptide antigen binding;","K06751","MHC1; MHC class I antigen"]
["ENSRNOG00000049771",4102,345.122872,1995,128.3392242,2.689145693,1.42714792,0,0,"up","yes","Gstt1","protein_coding","chr20:12856669-12873585:+","gi|16757988|ref|NP_445745.1|",1277,{"v":3E-175,"d":"3.00E-175"},"glutathione S-transferase theta-1 [Rattus norvegicus]","gi|55926212|ref|NM_053293.2|",943,0,"Rattus norvegicus glutathione S-transferase theta 1 (Gstt1), mRNA","Q01579",496,{"v":9e-177,"d":"9.00E-177"},"Glutathione S-transferase theta-1","SMb20420",70.9,{"v":1E-13,"d":"1.00E-13"},"COG0625","pfam02798","GST_N","Glutathione S-transferase, N-terminal domain. Function: conjugation of reduced glutathione to a variety of targets. Also included in the alignment, but are not GSTs: * S-crystallins from squid. Similarity to GST previously noted. * Eukaryotic elongation factors 1-gamma. Not known to have GST activity; similarity not previously recognized. * HSP26 family of stress-related proteins. including auxin-regulated proteins in plants and stringent starvation proteins in Escherichia coli. Not known to have GST activity. Similarity not previously recognized. The glutathione molecule binds in a cleft between N and C-terminal domains - the catalytically important residues are proposed to reside in the N-terminal domain.","GO:0006304|DNA modification;GO:0006749|glutathione metabolic process;GO:0007568|aging;GO:0009410|response to xenobiotic stimulus;GO:0009751|response to salicylic acid;GO:0010269|response to selenium ion;GO:0014070|response to organic cyclic compound;GO:0018900|dichloromethane metabolic process;GO:0033197|response to vitamin E;GO:0098869|cellular oxidant detoxification;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004364|glutathione transferase activity;GO:0004602|glutathione peroxidase activity;GO:0047651|alkylhalidase activity;","K00799","GST, gst; glutathione S-transferase [EC:2.5.1.18]"]
["ENSRNOG00000031743",2305,193.9317942,741,47.66885469,4.068312433,2.024430478,{"v":2.5e-284,"d":"2.50E-284"},{"v":1.39e-282,"d":"1.39E-282"},"up","yes","Gbp2","protein_coding","chr2:231332284-231348571:+","gi|19424350|ref|NP_598308.1|",3150,0,"guanylate-binding protein 1 [Rattus norvegicus]","gi|402691659|ref|NM_133624.2|",2390,0,"Rattus norvegicus guanylate binding protein 2 (Gbp2), mRNA","Q63663",1212,0,"Guanylate-binding protein 1",".",".",".",".","pfam02841","GBP_C","Guanylate-binding protein, C-terminal domain. Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.","GO:0009617|response to bacterium;GO:0034504|protein localization to nucleus;GO:0035458|cellular response to interferon-beta;GO:0042832|defense response to protozoan;GO:0044406|adhesion of symbiont to host;GO:0050830|defense response to Gram-positive bacterium;GO:0071222|cellular response to lipopolysaccharide;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;","GO:0000139|Golgi membrane;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0031410|cytoplasmic vesicle;GO:0048471|perinuclear region of cytoplasm;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;","K20897","GBP2; guanylate-binding protein 2"]
["ENSRNOG00000022256",1176,98.94307593,100,6.433043818,15.38044489,3.94302533,{"v":5.09e-283,"d":"5.09E-283"},{"v":2.8e-281,"d":"2.80E-281"},"up","yes","Cxcl10","protein_coding","chr14:15704758-15706975:+","gi|146345511|sp|P48973.2|CXL10_RAT",421,{"v":2e-47,"d":"2.00E-47"},"RecName: Full=C-X-C motif chemokine 10; AltName: Full=10 kDa interferon gamma-induced protein; Short=Gamma-IP10; Short=IP-10; AltName: Full=Interferon-inducible protein 10; AltName: Full=Protein Mob-1; AltName: Full=Small-inducible cytokine B10; Flags: Precursor","gi|298906686|emb|FQ225221.1|",1154,0,"Rattus norvegicus TL0AEA54YL10 mRNA sequence","P48973",166,{"v":7e-49,"d":"7.00E-49"},"C-X-C motif chemokine 10",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0002690|positive regulation of leukocyte chemotaxis;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0008284|positive regulation of cell proliferation;GO:0009409|response to cold;GO:0009615|response to virus;GO:0009617|response to bacterium;GO:0010332|response to gamma radiation;GO:0010818|T cell chemotaxis;GO:0010819|regulation of T cell chemotaxis;GO:0010996|response to auditory stimulus;GO:0016525|negative regulation of angiogenesis;GO:0030335|positive regulation of cell migration;GO:0030593|neutrophil chemotaxis;GO:0031640|killing of cells of other organism;GO:0032496|response to lipopolysaccharide;GO:0033280|response to vitamin D;GO:0034605|cellular response to heat;GO:0042118|endothelial cell activation;GO:0042127|regulation of cell proliferation;GO:0042981|regulation of apoptotic process;GO:0045662|negative regulation of myoblast differentiation;GO:0050918|positive chemotaxis;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;GO:0051607|defense response to virus;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098|chemokine-mediated signaling pathway;GO:0071222|cellular response to lipopolysaccharide;GO:0090026|positive regulation of monocyte chemotaxis;GO:0098586|cellular response to virus;GO:1901509|regulation of endothelial tube morphogenesis;GO:1901740|negative regulation of myoblast fusion;GO:2000406|positive regulation of T cell migration;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0009897|external side of plasma membrane;","GO:0005125|cytokine activity;GO:0008009|chemokine activity;GO:0008201|heparin binding;GO:0042056|chemoattractant activity;GO:0045236|CXCR chemokine receptor binding;GO:0048248|CXCR3 chemokine receptor binding;","K12671","CXCL10, IP10; C-X-C motif chemokine 10"]
["ENSRNOG00000066573",5472,460.38819,3349,215.4426375,2.13694093,1.095547029,{"v":6.78e-273,"d":"6.78E-273"},{"v":3.55e-271,"d":"3.55E-271"},"up","yes","C4a","protein_coding","chr20:4005731-4020080:+","gi|158186621|ref|NP_113692.2|",9032,0,"complement C4 precursor [Rattus norvegicus]","gi|259013549|ref|NM_031504.3|",5356,0,"Rattus norvegicus complement component 4A (Rodgers blood group) (C4a), mRNA","P08649",3482,0,"Complement C4","TM0984",58.2,{"v":3e-07,"d":"3.00E-07"},"COG2373","pfam07678","A2M_comp","A-macroglobulin complement component. This family includes the complement components region of the alpha-2-macroglobulin family.",".",".",".",".","."]
["ENSRNOG00000029658",3215,270.4948887,1449,93.21480493,2.901844711,1.536970317,{"v":8.82e-271,"d":"8.82E-271"},{"v":4.53e-269,"d":"4.53E-269"},"up","yes","Rnf213","protein_coding","chr10:104656883-104757918:+","gi|672025745|ref|XP_008774086.1|",26896,0,"PREDICTED: E3 ubiquitin-protein ligase RNF213 isoform X1 [Rattus norvegicus]","gi|672025744|ref|XM_008775864.1|",14394,0,"PREDICTED: Rattus norvegicus ring finger protein 213 (Rnf213), transcript variant X1, mRNA","E9Q555",8763,0,"E3 ubiquitin-protein ligase RNF213",".",".",".",".","pfam13639","zf-RING_2","Ring finger domain.","GO:0001525|angiogenesis;GO:0002040|sprouting angiogenesis;GO:0006511|ubiquitin-dependent protein catabolic process;GO:0016567|protein ubiquitination;GO:0051260|protein homooligomerization;GO:0051865|protein autoubiquitination;GO:2000051|negative regulation of non-canonical Wnt signaling pathway;","GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004842|ubiquitin-protein transferase activity;GO:0046872|metal ion binding;","K22754","RNF213; E3 ubiquitin-protein ligase RNF213 [EC:2.3.2.27]"]
["ENSRNOG00000023969",1266,106.5152501,169,10.87184405,9.797348967,3.292391428,{"v":2.75e-266,"d":"2.75E-266"},1.39E-264,"up","yes","Herc6","protein_coding","chr4:87524493-87581744:-","gi|55249804|gb|AAH85921.1|",5197,0,"Herc6 protein, partial [Rattus norvegicus]","gi|672049854|ref|XM_008762963.1|",4089,0,"PREDICTED: Rattus norvegicus HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 (Herc6), transcript variant X2, mRNA","F2Z461",1543,0,"E3 ISG15--protein ligase Herc6","SPBP8B7.27",154,{"v":5e-37,"d":"5.00E-37"},"COG5021","pfam00632","HECT","HECT-domain (ubiquitin-transferase). The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.","GO:0002244|hematopoietic progenitor cell differentiation;GO:0009617|response to bacterium;GO:0016567|protein ubiquitination;","GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0004842|ubiquitin-protein transferase activity;","K22372","HERC5_6; E3 ISG15--protein ligase [EC:2.3.2.-]"]
["ENSRNOG00000010529",994,83.63045703,47,3.023530595,27.65986796,4.789722365,{"v":2.29e-263,"d":"2.29E-263"},{"v":1.13e-261,"d":"1.13E-261"},"up","yes","Thbs2","protein_coding","chr1:55670394-55699789:-","gi|281332082|ref|NP_001162609.1|",5716,0,"thrombospondin-2 precursor [Rattus norvegicus]","gi|281332081|ref|NM_001169138.1|",5728,0,"Rattus norvegicus thrombospondin 2 (Thbs2), mRNA","Q03350",2156,0,"Thrombospondin-2",".",".",".",".","pfam05735","TSP_C","Thrombospondin C-terminal region. This region is found at the C-terminus of thrombospondin and related proteins.","GO:0007155|cell adhesion;GO:0016525|negative regulation of angiogenesis;GO:0051965|positive regulation of synapse assembly;","GO:0005576|extracellular region;GO:0005604|basement membrane;GO:0031012|extracellular matrix;GO:0031091|platelet alpha granule;GO:0062023|collagen-containing extracellular matrix;","GO:0005509|calcium ion binding;GO:0008201|heparin binding;","K04659","THBS2S; thrombospondin 2/3/4/5"]
["ENSRNOG00000024159",2077,174.748953,658,42.32942833,4.128308836,2.045550902,{"v":7.46e-260,"d":"7.46E-260"},3.63E-258,"up","yes","Fcer1g","protein_coding","chr13:83649449-83671443:-","gi|58865384|ref|NP_001011907.1|",2498,0,"NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial precursor [Rattus norvegicus]","gi|564381782|ref|XM_003751277.2|",1602,0,"PREDICTED: Rattus norvegicus NADH dehydrogenase (ubiquinone) Fe-S protein 2 (Ndufs2), transcript variant X1, mRNA","Q641Y2",966,0,"NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial","RP354",570,0,"COG0649","pfam00346","Complex1_49kDa","Respiratory-chain NADH dehydrogenase, 49 Kd subunit.","GO:0001798|positive regulation of type IIa hypersensitivity;GO:0001805|positive regulation of type III hypersensitivity;GO:0001812|positive regulation of type I hypersensitivity;GO:0002283|neutrophil activation involved in immune response;GO:0002292|T cell differentiation involved in immune response;GO:0002431|Fc receptor mediated stimulatory signaling pathway;GO:0002554|serotonin secretion by platelet;GO:0006911|phagocytosis, engulfment;GO:0007165|signal transduction;GO:0007166|cell surface receptor signaling pathway;GO:0007229|integrin-mediated signaling pathway;GO:0010543|regulation of platelet activation;GO:0016064|immunoglobulin mediated immune response;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030316|osteoclast differentiation;GO:0030593|neutrophil chemotaxis;GO:0031623|receptor internalization;GO:0032733|positive regulation of interleukin-10 production;GO:0032753|positive regulation of interleukin-4 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032765|positive regulation of mast cell cytokine production;GO:0033026|negative regulation of mast cell apoptotic process;GO:0038094|Fc-gamma receptor signaling pathway;GO:0038095|Fc-epsilon receptor signaling pathway;GO:0038156|interleukin-3-mediated signaling pathway;GO:0042590|antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:0042742|defense response to bacterium;GO:0043306|positive regulation of mast cell degranulation;GO:0045087|innate immune response;GO:0045576|mast cell activation;GO:0050766|positive regulation of phagocytosis;GO:0050776|regulation of immune response;GO:0050778|positive regulation of immune response;GO:0071404|cellular response to low-density lipoprotein particle stimulus;GO:0072659|protein localization to plasma membrane;GO:2000010|positive regulation of protein localization to cell surface;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0032998|Fc-epsilon receptor I complex;","GO:0005515|protein binding;GO:0019767|IgE receptor activity;GO:0019863|IgE binding;GO:0019864|IgG binding;GO:0042802|identical protein binding;","K07983","FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma"]
["ENSRNOG00000011754",1340,112.74126,220,14.1526964,7.966062211,2.993866747,1.59E-258,{"v":7.65e-257,"d":"7.65E-257"},"up","yes","Myom2","protein_coding","chr16:74520157-74592772:-","gi|281306803|ref|NP_001162612.1|",7610,0,"myomesin-2 [Rattus norvegicus]","gi|672080527|ref|XM_006253389.2|",4896,0,"PREDICTED: Rattus norvegicus myomesin 2 (Myom2), transcript variant X1, mRNA","P54296",2676,0,"Myomesin-2",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0002074|extraocular skeletal muscle development;GO:0006936|muscle contraction;GO:0045214|sarcomere organization;","GO:0031430|M band;","GO:0019900|kinase binding;GO:0051015|actin filament binding;","K24495","MYOM; myomesin"]
["ENSRNOG00000069480",2137,179.7970691,708,45.54595023,3.947597276,1.980974817,{"v":1.89e-256,"d":"1.89E-256"},{"v":9.02e-255,"d":"9.02E-255"},"up","yes","ENSRNOG00000069480","protein_coding","chr20:3310825-3421372:-","gi|3493249|gb|AAC33332.1|",1284,{"v":3e-159,"d":"3.00E-159"},"MHC class I antigen [Rattus norvegicus]","gi|46237620|emb|BX883046.1|",1780,0,"Rattus norvegicus chromosome 20, major histocompatibility complex, assembled from 40 BACs, strain Brown Norway (BN/ssNHsd), RT1n haplotype; segment 5/11","P16391",465,{"v":6E-148,"d":"6.00E-148"},"RT1 class I histocompatibility antigen, AA alpha chain",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.",".",".",".",".","."]
["ENSRNOG00000011054",1532,128.8952316,341,21.93667942,5.875785897,2.554781828,1.13E-250,{"v":5.25e-249,"d":"5.25E-249"},"up","yes","Laptm5","protein_coding","chr5:143087759-143109807:+","gi|40254749|ref|NP_445990.2|",1091,{"v":3e-138,"d":"3.00E-138"},"lysosomal-associated transmembrane protein 5 [Rattus norvegicus]","gi|40254748|ref|NM_053538.2|",1978,0,"Rattus norvegicus lysosomal protein transmembrane 5 (Laptm5), mRNA","Q61168",400,{"v":2e-130,"d":"2.00E-130"},"Lysosomal-associated transmembrane protein 5",".",".",".",".","pfam03821","Mtp","Golgi 4-transmembrane spanning transporter.","GO:0002357|defense response to tumor cell;GO:0002720|positive regulation of cytokine production involved in immune response;GO:0006622|protein targeting to lysosome;GO:0006886|intracellular protein transport;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0012502|induction of programmed cell death;GO:0031398|positive regulation of protein ubiquitination;GO:0032689|negative regulation of interferon-gamma production;GO:0032703|negative regulation of interleukin-2 production;GO:0032735|positive regulation of interleukin-12 production;GO:0032755|positive regulation of interleukin-6 production;GO:0043410|positive regulation of MAPK cascade;GO:0046007|negative regulation of activated T cell proliferation;GO:0050860|negative regulation of T cell receptor signaling pathway;GO:0050868|negative regulation of T cell activation;GO:0050869|negative regulation of B cell activation;GO:0060907|positive regulation of macrophage cytokine production;GO:0061462|protein localization to lysosome;GO:0090160|Golgi to lysosome transport;GO:0097214|positive regulation of lysosomal membrane permeability;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1903052|positive regulation of proteolysis involved in cellular protein catabolic process;GO:1903265|positive regulation of tumor necrosis factor-mediated signaling pathway;GO:1904093|negative regulation of autophagic cell death;GO:1990830|cellular response to leukemia inhibitory factor;GO:2000060|positive regulation of ubiquitin-dependent protein catabolic process;GO:2000646|positive regulation of receptor catabolic process;","GO:0005764|lysosome;GO:0005765|lysosomal membrane;GO:0005829|cytosol;GO:0005887|integral component of plasma membrane;GO:0030133|transport vesicle;GO:0031410|cytoplasmic vesicle;GO:0032991|protein-containing complex;GO:0048471|perinuclear region of cytoplasm;","GO:0019899|enzyme binding;GO:0031625|ubiquitin protein ligase binding;GO:0140036|ubiquitin-dependent protein binding;","K12387","LAPTM; lysosomal-associated transmembrane protein"]
["ENSRNOG00000028814",1097,92.29638971,115,7.398000391,12.47585629,3.641066934,3.31E-250,{"v":1.53e-248,"d":"1.53E-248"},"up","yes","Oasl2","protein_coding","chr12:41709435-41722547:-","gi|672073310|ref|XP_008767549.1|",2522,0,"PREDICTED: 2'-5'-oligoadenylate synthase-like protein 2 isoform X1 [Rattus norvegicus]","gi|672073309|ref|XM_008769327.1|",2214,0,"PREDICTED: Rattus norvegicus 2'-5' oligoadenylate synthetase-like 2 (Oasl2), transcript variant X1, mRNA","Q5MYT9",968,0,"2'-5'-oligoadenylate synthase-like protein 2",".",".",".",".","pfam10421","OAS1_C","2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus. This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between 320 and 344 at the extreme C-terminal end. Oligoadenylate synthetases are antiviral enzymes that counteract vial attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesize 2'.5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication. This domain is often associated with NTP_transf_2 pfam01909.","GO:0009615|response to virus;GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0051607|defense response to virus;GO:0060700|regulation of ribonuclease activity;","GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0016020|membrane;","GO:0001730|2'-5'-oligoadenylate synthetase activity;GO:0003725|double-stranded RNA binding;GO:0005524|ATP binding;GO:0046872|metal ion binding;","K14608","OASL; 2'-5'-oligoadenylate synthase-like protein"]
["ENSRNOG00000032844",3443,289.6777299,1731,111.3559885,2.601366427,1.379269631,{"v":7.62e-247,"d":"7.62E-247"},3.43E-245,"up","yes","RT1-Da","protein_coding","chr20:4512911-4518455:+","gi|40556829|gb|AAR87772.1|",1061,{"v":6e-131,"d":"6.00E-131"},"MHC class II antigen alpha chain [Rattus norvegicus]","gi|46237557|emb|BX883043.1|",3116,0,"Rattus norvegicus chromosome 20, major histocompatibility complex, assembled from 40 BACs, strain Brown Norway (BN/ssNHsd), RT1n haplotype; segment 2/11","P14439",384,{"v":2E-121,"d":"2.00E-121"},"H-2 class II histocompatibility antigen, E-U alpha chain",".",".",".",".","pfam00993","MHC_II_alpha","Class II histocompatibility antigen, alpha domain.","GO:0001916|positive regulation of T cell mediated cytotoxicity;GO:0002250|adaptive immune response;GO:0002381|immunoglobulin production involved in immunoglobulin mediated immune response;GO:0002469|myeloid dendritic cell antigen processing and presentation;GO:0002491|antigen processing and presentation of endogenous peptide antigen via MHC class II;GO:0002503|peptide antigen assembly with MHC class II protein complex;GO:0002504|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;GO:0008150|biological_process;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0032831|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0043382|positive regulation of memory T cell differentiation;GO:0045622|regulation of T-helper cell differentiation;GO:0050870|positive regulation of T cell activation;GO:0050890|cognition;GO:2000516|positive regulation of CD4-positive, alpha-beta T cell activation;","GO:0001772|immunological synapse;GO:0005575|cellular_component;GO:0005764|lysosome;GO:0005765|lysosomal membrane;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0031902|late endosome membrane;GO:0042613|MHC class II protein complex;","GO:0003674|molecular_function;GO:0023026|MHC class II protein complex binding;GO:0030247|polysaccharide binding;GO:0042605|peptide antigen binding;GO:0042608|T cell receptor binding;","K06752","MHC2; MHC class II antigen"]
["ENSRNOG00000014610",1621,136.3832705,405,26.05382746,5.234673127,2.388099452,1.39E-245,{"v":6.21e-244,"d":"6.21E-244"},"up","yes","Anpep","protein_coding","chr1:133767332-133785789:-","gi|564329002|ref|XP_006229469.1|",4869,0,"PREDICTED: aminopeptidase N isoform X1 [Rattus norvegicus]","gi|672037160|ref|XM_006229408.2|",3319,0,"PREDICTED: Rattus norvegicus alanyl (membrane) aminopeptidase (Anpep), transcript variant X2, mRNA","P15684",1877,0,"Aminopeptidase N","YHR047c",377,{"v":3e-113,"d":"3.00E-113"},"COG0308","pfam01433","Peptidase_M1","Peptidase family M1. Members of this family are aminopeptidases. The members differ widely in specificity, hydrolysing acidic, basic or neutral N-terminal residues. This family includes leukotriene-A4 hydrolase, this enzyme also has an aminopeptidase activity.","GO:0001525|angiogenesis;GO:0006508|proteolysis;GO:0007165|signal transduction;GO:0008217|regulation of blood pressure;GO:0030154|cell differentiation;GO:0035814|negative regulation of renal sodium excretion;GO:0043171|peptide catabolic process;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005793|endoplasmic reticulum-Golgi intermediate compartment;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0031526|brush border membrane;GO:0070062|extracellular exosome;","GO:0004177|aminopeptidase activity;GO:0008237|metallopeptidase activity;GO:0008270|zinc ion binding;GO:0042277|peptide binding;GO:0070006|metalloaminopeptidase activity;","K11140","ANPEP, CD13; aminopeptidase N [EC:3.4.11.2]"]
["ENSRNOG00000037198",876,73.70249533,32,2.058574022,35.80269378,5.161996234,3.64E-237,1.58E-235,"up","yes","Usp18","protein_coding","chr4:154471592-154499144:+","gi|62078849|ref|NP_001014080.1|",1960,0,"ubl carboxyl-terminal hydrolase 18 [Rattus norvegicus]","gi|62078848|ref|NM_001014058.1|",1590,0,"Rattus norvegicus ubiquitin specific peptidase 18 (Usp18), mRNA","Q9WTV6",658,0,"Ubl carboxyl-terminal hydrolase 18","SPBC713.02c",114,{"v":2e-25,"d":"2.00E-25"},"COG5077","pfam00443","UCH","Ubiquitin carboxyl-terminal hydrolase.","GO:0006511|ubiquitin-dependent protein catabolic process;GO:0009617|response to bacterium;GO:0016579|protein deubiquitination;GO:0035634|response to stilbenoid;GO:0050727|regulation of inflammatory response;GO:0060339|negative regulation of type I interferon-mediated signaling pathway;","GO:0005634|nucleus;GO:0005829|cytosol;GO:0043231|intracellular membrane-bounded organelle;","GO:0004197|cysteine-type endopeptidase activity;GO:0004843|thiol-dependent ubiquitin-specific protease activity;GO:0019785|ISG15-specific protease activity;","K11846","USP18_41; ubiquitin carboxyl-terminal hydrolase 18/41 [EC:3.4.19.12]"]
["ENSRNOG00000031053",3678,309.4495181,1986,127.7602502,2.422111083,1.276265032,{"v":4.24e-234,"d":"4.24E-234"},1.76E-232,"up","yes","Mt-nd4l","protein_coding","chrMT:9870-10166:+","gi|998247805|emb|CXH16302.1|",390,{"v":2E-46,"d":"2.00E-46"},"hypothetical protein PBK173_000516800 [Plasmodium berghei]","gi|755572967|gb|KP244683.1|",297,{"v":6E-153,"d":"6.00E-153"},"Rattus norvegicus isolate 115 mitochondrion, complete genome","P05507",136,{"v":7e-41,"d":"7.00E-41"},"NADH-ubiquinone oxidoreductase chain 4L",".",".",".",".","pfam00420","Oxidored_q2","NADH-ubiquinone/plastoquinone oxidoreductase chain 4L.","GO:0008150|biological_process;GO:0042773|ATP synthesis coupled electron transport;","GO:0005575|cellular_component;GO:0005743|mitochondrial inner membrane;GO:0005747|mitochondrial respiratory chain complex I;GO:0016021|integral component of membrane;GO:0030964|NADH dehydrogenase complex;GO:0070469|respiratory chain;","GO:0003674|molecular_function;GO:0008137|NADH dehydrogenase (ubiquinone) activity;","K03882","ND4L; NADH-ubiquinone oxidoreductase chain 4L [EC:7.1.1.2]"]
["ENSRNOG00000025695",4800,403.8492895,2983,191.8976971,2.104503053,1.073479603,{"v":6.48e-232,"d":"6.48E-232"},{"v":2.67e-230,"d":"2.67E-230"},"up","yes","Tns3","protein_coding","chr14:83173649-83405998:-","gi|672076878|ref|XP_008768558.1|",7631,0,"PREDICTED: tensin-3 isoform X9 [Rattus norvegicus]","gi|672076877|ref|XM_008770336.1|",8182,0,"PREDICTED: Rattus norvegicus tensin 3 (Tns3), transcript variant X9, mRNA","Q5SSZ5",2715,0,"Tensin-3","SPBC609.02",84.3,{"v":8e-16,"d":"8.00E-16"},"COG2453","pfam08416","PTB","Phosphotyrosine-binding domain. The phosphotyrosine-binding domain (PTB, also phosphotyrosine-interaction or PI domain) in the protein tensin tends to be found at the C-terminus. Tensin is a multi-domain protein that binds to actin filaments and functions as a focal-adhesion molecule (focal adhesions are regions of plasma membrane through which cells attach to the extracellular matrix). Human tensin has actin-binding sites, an SH2 (pfam00017) domain and a region similar to the tumor suppressor PTEN. The PTB domain interacts with the cytoplasmic tails of beta integrin by binding to an NPXY motif.","GO:0008284|positive regulation of cell proliferation;GO:0016311|dephosphorylation;GO:0016477|cell migration;GO:0035556|intracellular signal transduction;GO:0048286|lung alveolus development;","GO:0005829|cytosol;GO:0005925|focal adhesion;","GO:0016791|phosphatase activity;","K18080","TNS; tensin"]
["ENSRNOG00000052981",1459,122.753357,345,22.19400117,5.530925046,2.467520791,1.02E-229,{"v":4.09e-228,"d":"4.09E-228"},"up","yes","AABR07058464.1","protein_coding","chr7:109131064-109147649:-","gi|392341539|ref|XP_003754362.1|",1532,0,"PREDICTED: apolipoprotein L3-like isoform X1 [Rattus norvegicus]","gi|672022074|ref|XM_008776507.1|",1945,0,"PREDICTED: Rattus norvegicus apolipoprotein L3-like (LOC100910885), transcript variant X1, mRNA","O95236",195,{"v":8e-54,"d":"8.00E-54"},"Apolipoprotein L3",".",".",".",".","pfam05461","ApoL","Apolipoprotein L. Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.",".",".",".",".","."]
["ENSRNOG00000001187",940,79.08715253,82,5.275095931,14.99255247,3.906174117,{"v":2.63e-225,"d":"2.63E-225"},{"v":1.03e-223,"d":"1.03E-223"},"up","yes","Oasl","protein_coding","chr12:41682900-41695641:-","gi|403399503|sp|G3V645.1|OASL1_RAT",2628,0,"RecName: Full=2'-5'-oligoadenylate synthase-like protein 1","gi|57527343|ref|NM_001009681.1|",1977,0,"Rattus norvegicus 2'-5'-oligoadenylate synthetase-like (Oasl), mRNA","G3V645",1016,0,"2'-5'-oligoadenylate synthase-like protein 1",".",".",".",".","pfam10421","OAS1_C","2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus. This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between 320 and 344 at the extreme C-terminal end. Oligoadenylate synthetases are antiviral enzymes that counteract vial attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesize 2'.5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication. This domain is often associated with NTP_transf_2 pfam01909.","GO:0009615|response to virus;GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0051607|defense response to virus;GO:0060700|regulation of ribonuclease activity;GO:0070106|interleukin-27-mediated signaling pathway;GO:1900246|positive regulation of RIG-I signaling pathway;","GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016020|membrane;","GO:0003677|DNA binding;GO:0003725|double-stranded RNA binding;","K14608","OASL; 2'-5'-oligoadenylate synthase-like protein"]
["ENSRNOG00000033517",2602,218.919969,1164,74.88063005,2.923586098,1.547739079,8.69E-222,3.36E-220,"up","yes","ENSRNOG00000033517","protein_coding","chr1:19107386-19108232:+","gi|820987686|ref|XP_012362357.1|",928,{"v":2e-123,"d":"2.00E-123"},"PREDICTED: translationally-controlled tumor protein isoform X2 [Nomascus leucogenys]","gi|298914786|emb|FQ232768.1|",783,0,"Rattus norvegicus TL0AEA64YI02 mRNA sequence","P63029",349,{"v":1e-120,"d":"1.00E-120"},"Translationally-controlled tumor protein",".",".",".",".","pfam00838","TCTP","Translationally controlled tumor protein.",".",".",".",".","."]
["ENSRNOG00000015736",2075,174.5806824,787,50.62805485,3.448299228,1.78588497,{"v":7.23e-217,"d":"7.23E-217"},{"v":2.72e-215,"d":"2.72E-215"},"up","yes","Dhrs3","protein_coding","chr5:156747962-156782417:+","gi|148747124|ref|NP_001032276.3|",1610,0,"short-chain dehydrogenase/reductase 3 [Rattus norvegicus]","gi|119434399|gb|EF125189.1|",2039,0,"Rattus norvegicus retinal dehydrogenase/reductase family member 3 mRNA, complete cds","O88876",621,0,"Short-chain dehydrogenase/reductase 3","MA2687",100,{"v":2e-22,"d":"2.00E-22"},"COG1028","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.","GO:0001523|retinoid metabolic process;GO:0003151|outflow tract morphogenesis;GO:0030278|regulation of ossification;GO:0042572|retinol metabolic process;GO:0048385|regulation of retinoic acid receptor signaling pathway;GO:0048387|negative regulation of retinoic acid receptor signaling pathway;GO:0060021|roof of mouth development;GO:0060349|bone morphogenesis;GO:0060411|cardiac septum morphogenesis;","GO:0005811|lipid droplet;GO:0016021|integral component of membrane;","GO:0004745|retinol dehydrogenase activity;GO:0016616|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;","K11146","DHRS3; short-chain dehydrogenase/reductase 3 [EC:1.1.1.300]"]
["ENSRNOG00000028668",1513,127.2966615,439,28.24106236,4.50750258,2.172328317,{"v":9.41e-205,"d":"9.41E-205"},{"v":3.44e-203,"d":"3.44E-203"},"up","yes","Slc28a2","protein_coding","chr3:109366996-109387702:+","gi|15721849|gb|AAK38150.1|",3322,0,"concentrative Na+ nucleoside cotransporter [Rattus norvegicus]","gi|15721848|gb|AY029302.1|",2617,0,"Rattus norvegicus concentrative Na+ nucleoside cotransporter mRNA, complete cds","Q62773",1282,0,"Sodium/nucleoside cotransporter 2","all0378",345,{"v":2e-108,"d":"2.00E-108"},"COG1972","pfam07662","Nucleos_tra2_C","Na+ dependent nucleoside transporter C-terminus. This family consists of nucleoside transport proteins. Members include a purine-specific Na+-nucleoside cotransporter localized to the bile canalicular membrane and a Na+-dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine, which also transports the anti-viral nucleoside analogues AZT and ddC. This alignment covers the C-terminus of this family of transporters.","GO:0001895|retina homeostasis;GO:0006836|neurotransmitter transport;GO:0015855|pyrimidine nucleobase transport;GO:0015860|purine nucleoside transmembrane transport;GO:0015862|uridine transport;GO:0032238|adenosine transport;GO:0034394|protein localization to cell surface;GO:0035340|inosine transport;GO:0072531|pyrimidine-containing compound transmembrane transport;GO:1901642|nucleoside transmembrane transport;GO:1904823|purine nucleobase transmembrane transport;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0012506|vesicle membrane;GO:0030135|coated vesicle;GO:0031526|brush border membrane;","GO:0005326|neurotransmitter transporter activity;GO:0005337|nucleoside transmembrane transporter activity;GO:0005345|purine nucleobase transmembrane transporter activity;GO:0005415|nucleoside:sodium symporter activity;GO:0015211|purine nucleoside transmembrane transporter activity;GO:0015213|uridine transmembrane transporter activity;GO:0015293|symporter activity;GO:0015389|pyrimidine- and adenine-specific:sodium symporter activity;","K11536","SLC28A; pyrimidine nucleoside transport protein"]
["ENSRNOG00000063679",1164,97.9334527,240,15.43930516,6.343125656,2.665193922,{"v":6.34e-200,"d":"6.34E-200"},2.26E-198,"up","yes","ENSRNOG00000063679","protein_coding","chr4:31361669-31376415:-","gi|672018010|ref|XP_008773891.1|",8341,0,"PREDICTED: LOW QUALITY PROTEIN: sterile alpha motif domain-containing protein 9-like isoform X1 [Rattus norvegicus]","gi|672018009|ref|XM_008775669.1|",5182,0,"PREDICTED: Rattus norvegicus sterile alpha motif domain-containing protein 9-like (LOC103690031), transcript variant X1, mRNA","Q69Z37",2834,0,"Sterile alpha motif domain-containing protein 9-like",".",".",".",".","pfam09235","Ste50p-SAM","Ste50p, sterile alpha motif. The fungal Ste50p SAM domain consists of five helices, which form a compact, globular fold. It is required for mediation of homodimerization and heterodimerization (and in some cases oligomerization) of the protein.",".",".",".",".","."]
["ENSRNOG00000008045",757,63.69039837,54,3.473843662,18.33427309,4.196471163,{"v":1.05e-189,"d":"1.05E-189"},3.57E-188,"up","yes","Slamf9","protein_coding","chr13:84941982-84944748:+","gi|157787012|ref|NP_001099441.1|",1339,0,"SLAM family member 9 precursor [Rattus norvegicus]","gi|157787011|ref|NM_001105971.1|",1111,0,"Rattus norvegicus SLAM family member 9 (Slamf9), mRNA","Q9D780",410,{"v":3e-141,"d":"3.00E-141"},"SLAM family member 9",".",".",".",".","pfam13927","Ig_3","Immunoglobulin domain. This family contains immunoglobulin-like domains.","GO:0002273|plasmacytoid dendritic cell differentiation;GO:0002373|plasmacytoid dendritic cell cytokine production;GO:0002410|plasmacytoid dendritic cell chemotaxis;GO:0042110|T cell activation;GO:0042742|defense response to bacterium;","GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000007862",3186,268.0549659,1796,115.537467,2.32006961,1.214168092,{"v":6.17e-188,"d":"6.17E-188"},{"v":2.06e-186,"d":"2.06E-186"},"up","yes","Acat1","protein_coding","chr8:53979813-54008855:-","gi|401461805|ref|NP_058771.2|",1959,0,"acetyl-CoA acetyltransferase, mitochondrial precursor [Rattus norvegicus]","gi|401461804|ref|NM_017075.2|",2186,0,"Rattus norvegicus acetyl-CoA acetyltransferase 1 (Acat1), mRNA","P17764",759,0,"Acetyl-CoA acetyltransferase, mitochondrial","SPBC215.09c",372,{"v":2E-120,"d":"2.00E-120"},"COG0183","pfam00108","Thiolase_N","Thiolase, N-terminal domain. Thiolase is reported to be structurally related to beta-ketoacyl synthase (pfam00109), and also chalcone synthase.","GO:0001889|liver development;GO:0006085|acetyl-CoA biosynthetic process;GO:0006550|isoleucine catabolic process;GO:0006635|fatty acid beta-oxidation;GO:0007420|brain development;GO:0009725|response to hormone;GO:0014070|response to organic cyclic compound;GO:0015936|coenzyme A metabolic process;GO:0015937|coenzyme A biosynthetic process;GO:0042594|response to starvation;GO:0046356|acetyl-CoA catabolic process;GO:0046952|ketone body catabolic process;GO:0060612|adipose tissue development;GO:0072229|metanephric proximal convoluted tubule development;GO:1902860|propionyl-CoA biosynthetic process;","GO:0005739|mitochondrion;GO:0005759|mitochondrial matrix;","GO:0003985|acetyl-CoA C-acetyltransferase activity;GO:0016453|C-acetyltransferase activity;GO:0019899|enzyme binding;GO:0030955|potassium ion binding;GO:0042802|identical protein binding;","K00626","ACAT, atoB; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]"]
["ENSRNOG00000030210",719,60.49325816,41,2.637547966,22.93541537,4.519505131,{"v":6.96e-187,"d":"6.96E-187"},2.31E-185,"up","yes","Fndc1","protein_coding","chr1:47281844-47364259:+","gi|564325199|ref|XP_006227933.1|",5986,0,"PREDICTED: fibronectin type III domain-containing protein 1 isoform X1 [Rattus norvegicus]","gi|672034288|ref|XM_006227871.2|",6335,0,"PREDICTED: Rattus norvegicus fibronectin type III domain containing 1 (Fndc1), transcript variant X1, mRNA","Q2Q0I9",2176,0,"Fibronectin type III domain-containing protein 1",".",".",".",".","pfam00041","fn3","Fibronectin type III domain.","GO:0001934|positive regulation of protein phosphorylation;GO:0010666|positive regulation of cardiac muscle cell apoptotic process;GO:0051223|regulation of protein transport;GO:0071456|cellular response to hypoxia;","GO:0005576|extracellular region;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0016607|nuclear speck;GO:0031966|mitochondrial membrane;",".","K24484","FNDC1; fibronectin type III domain-containing protein 1"]
["ENSRNOG00000004009",1652,138.9914638,611,39.30589773,3.5361478,1.822178576,{"v":7.11e-178,"d":"7.11E-178"},{"v":2.24e-176,"d":"2.24E-176"},"up","yes","ENSRNOG00000004009","protein_coding","chrX:127287979-127317223:+","gi|16924020|ref|NP_476496.1|",3562,0,"xaa-Pro aminopeptidase 2 precursor [Rattus norvegicus]","gi|49258141|gb|BC074017.1|",3276,0,"Rattus norvegicus X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound, mRNA (cDNA clone MGC:91533 IMAGE:7098467), complete cds","Q99MA2",1376,0,"Xaa-Pro aminopeptidase 2","VC0067",352,{"v":9e-107,"d":"9.00E-107"},"COG0006","pfam00557","Peptidase_M24","Metallopeptidase family M24. This family contains metallopeptidases. It also contains non-peptidase homologues such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.","GO:0006508|proteolysis;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0031225|anchored component of membrane;GO:0070062|extracellular exosome;","GO:0003674|molecular_function;GO:0046872|metal ion binding;GO:0070006|metalloaminopeptidase activity;","K14208","XPNPEP2; Xaa-Pro aminopeptidase 2 [EC:3.4.11.9]"]
["ENSRNOG00000012557",1722,144.8809326,665,42.77974139,3.386671539,1.759868072,{"v":9.75e-177,"d":"9.75E-177"},{"v":3.05e-175,"d":"3.05E-175"},"up","yes","Lgals5","protein_coding","chr10:63853935-63857153:-","gi|149053564|gb|EDM05381.1|",717,{"v":2E-91,"d":"2.00E-91"},"rCG35210 [Rattus norvegicus]","gi|298914355|emb|FQ225984.1|",811,0,"Rattus norvegicus TL0AEA3YH09 mRNA sequence","P47967",264,{"v":1e-86,"d":"1.00E-86"},"Galectin-5",".",".",".",".","pfam00337","Gal-bind_lectin","Galactoside-binding lectin. This family contains galactoside binding lectins.   The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).","GO:0010628|positive regulation of gene expression;GO:0032689|negative regulation of interferon-gamma production;GO:0070234|positive regulation of T cell apoptotic process;GO:2000562|negative regulation of CD4-positive, alpha-beta T cell proliferation;","GO:0005634|nucleus;GO:0005829|cytosol;","GO:0016936|galactoside binding;GO:0030246|carbohydrate binding;GO:0030395|lactose binding;","K17522","LGALS5; galectin-5"]
["ENSRNOG00000017703",1963,165.1575324,864,55.58149859,2.971447991,1.57116613,1.68E-171,5.09E-170,"up","yes","Unc93b1","protein_coding","chr1:201152693-201178338:+","gi|564332335|ref|XP_006230895.1|",2378,0,"PREDICTED: protein unc-93 homolog B1 isoform X1 [Rattus norvegicus]","gi|564332334|ref|XM_006230833.1|",2075,0,"PREDICTED: Rattus norvegicus unc-93 homolog B1 (C. elegans) (Unc93b1), transcript variant X1, mRNA","Q8VCW4",905,0,"Protein unc-93 homolog B1",".",".",".",".","pfam05978","UNC-93","Ion channel regulatory protein UNC-93. This family of proteins is a component of a multi-subunit protein complex which is involved in the coordination of muscle contraction. UNC-93 is most likely an ion channel regulatory protein.","GO:0000902|cell morphogenesis;GO:0002224|toll-like receptor signaling pathway;GO:0006886|intracellular protein transport;GO:0008150|biological_process;GO:0019882|antigen processing and presentation;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0032735|positive regulation of interleukin-12 production;GO:0032755|positive regulation of interleukin-6 production;GO:0034138|toll-like receptor 3 signaling pathway;GO:0034154|toll-like receptor 7 signaling pathway;GO:0034162|toll-like receptor 9 signaling pathway;","GO:0005575|cellular_component;GO:0005764|lysosome;GO:0005768|endosome;GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;GO:0032009|early phagosome;","GO:0003674|molecular_function;GO:0035325|Toll-like receptor binding;",".","."]
["ENSRNOG00000000815",1870,157.3329524,795,51.14269836,3.076352195,1.621220679,{"v":5.77e-171,"d":"5.77E-171"},{"v":1.72e-169,"d":"1.72E-169"},"up","yes","Smpdl3a","protein_coding","chr20:37132592-37155567:+","gi|53850608|ref|NP_001005539.1|",2397,0,"acid sphingomyelinase-like phosphodiesterase 3a precursor [Rattus norvegicus]","gi|53850607|ref|NM_001005539.1|",1661,0,"Rattus norvegicus sphingomyelin phosphodiesterase, acid-like 3A (Smpdl3a), mRNA","Q641Z7",927,0,"Acid sphingomyelinase-like phosphodiesterase 3a",".",".",".",".","pfam00149","Metallophos","Calcineurin-like phosphoesterase. This family includes a diverse range of phosphoesterases, including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD or yeast MRE11. The most conserved regions in this superfamily centre around the metal chelating residues.","GO:0009143|nucleoside triphosphate catabolic process;","GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0008081|phosphoric diester hydrolase activity;GO:0008270|zinc ion binding;","K01128","SMPDL3; sphingomyelin phosphodiesterase acid-like 3 [EC:3.1.4.-]"]
["ENSRNOG00000005871",734,61.75528719,79,5.082104617,12.15151829,3.603064679,{"v":8.23e-167,"d":"8.23E-167"},{"v":2.41e-165,"d":"2.41E-165"},"up","yes","Il1rn","protein_coding","chr3:7111550-7127445:+","gi|564339611|ref|XP_006233698.1|",857,{"v":3e-108,"d":"3.00E-108"},"PREDICTED: interleukin-1 receptor antagonist protein isoform X1 [Rattus norvegicus]","gi|672044714|ref|XM_006233636.2|",1947,0,"PREDICTED: Rattus norvegicus interleukin 1 receptor antagonist (Il1rn), transcript variant X1, mRNA","P25086",329,{"v":2E-107,"d":"2.00E-107"},"Interleukin-1 receptor antagonist protein",".",".",".",".","pfam00340","IL1","Interleukin-1 / 18. This family includes interleukin-1 and interleukin-18.","GO:0001660|fever generation;GO:0002437|inflammatory response to antigenic stimulus;GO:0002439|chronic inflammatory response to antigenic stimulus;GO:0006629|lipid metabolic process;GO:0006953|acute-phase response;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007165|signal transduction;GO:0007565|female pregnancy;GO:0007613|memory;GO:0009410|response to xenobiotic stimulus;GO:0009968|negative regulation of signal transduction;GO:0010243|response to organonitrogen compound;GO:0014050|negative regulation of glutamate secretion;GO:0014070|response to organic cyclic compound;GO:0014823|response to activity;GO:0019233|sensory perception of pain;GO:0019752|carboxylic acid metabolic process;GO:0030073|insulin secretion;GO:0030336|negative regulation of cell migration;GO:0032496|response to lipopolysaccharide;GO:0034115|negative regulation of heterotypic cell-cell adhesion;GO:0042594|response to starvation;GO:0043066|negative regulation of apoptotic process;GO:0043507|positive regulation of JUN kinase activity;GO:0045837|negative regulation of membrane potential;GO:0051384|response to glucocorticoid;GO:0070555|response to interleukin-1;GO:0070670|response to interleukin-4;GO:0071874|cellular response to norepinephrine stimulus;GO:2000660|negative regulation of interleukin-1-mediated signaling pathway;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0031982|vesicle;","GO:0005125|cytokine activity;GO:0005149|interleukin-1 receptor binding;GO:0005150|interleukin-1, type I receptor binding;GO:0005151|interleukin-1, type II receptor binding;GO:0005152|interleukin-1 receptor antagonist activity;GO:0045352|interleukin-1 type I receptor antagonist activity;GO:0045353|interleukin-1 type II receptor antagonist activity;","K05481","IL1RN, IL1F3; interleukin 1 receptor antagonist"]
["ENSRNOG00000017874",969,81.52707532,200,12.86608764,6.336586352,2.66370584,{"v":1.12e-166,"d":"1.12E-166"},{"v":3.25e-165,"d":"3.25E-165"},"up","yes","Cd53","protein_coding","chr2:194352139-194399657:-","gi|148669936|gb|EDL01883.1|",1016,{"v":4e-132,"d":"4.00E-132"},"CD53 antigen, isoform CRA_a, partial [Mus musculus]","gi|401709945|ref|NM_012523.2|",1699,0,"Rattus norvegicus Cd53 molecule (Cd53), mRNA","P24485",392,{"v":2E-132,"d":"2.00E-132"},"Leukocyte surface antigen CD53",".",".",".",".","pfam00335","Tetraspannin","Tetraspanin family.","GO:0040008|regulation of growth;GO:1901741|positive regulation of myoblast fusion;","GO:0001772|immunological synapse;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005911|cell-cell junction;GO:0009986|cell surface;","GO:0042802|identical protein binding;","K06489","CD53, MOX44, TSPAN25; CD53 antigen"]
["ENSRNOG00000024899",722,60.74566396,74,4.760452426,12.76048126,3.673610836,{"v":1.86e-166,"d":"1.86E-166"},5.39E-165,"up","yes","Cxcl13","protein_coding","chr14:13608902-13613933:-","gi|564383008|ref|XP_006250772.1|",486,{"v":5e-57,"d":"5.00E-57"},"PREDICTED: C-X-C motif chemokine 13 isoform X1 [Rattus norvegicus]","gi|672075817|ref|XM_006250710.2|",1087,0,"PREDICTED: Rattus norvegicus chemokine (C-X-C motif) ligand 13 (Cxcl13), transcript variant X1, mRNA","O55038",139,{"v":2e-38,"d":"2.00E-38"},"C-X-C motif chemokine 13",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0002518|lymphocyte chemotaxis across high endothelial venule;GO:0006954|inflammatory response;GO:0007166|cell surface receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007267|cell-cell signaling;GO:0010820|positive regulation of T cell chemotaxis;GO:0030593|neutrophil chemotaxis;GO:0031640|killing of cells of other organism;GO:0033625|positive regulation of integrin activation;GO:0033634|positive regulation of cell-cell adhesion mediated by integrin;GO:0035754|B cell chemotaxis;GO:0035768|endothelial cell chemotaxis to fibroblast growth factor;GO:0035769|B cell chemotaxis across high endothelial venule;GO:0042742|defense response to bacterium;GO:0048535|lymph node development;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098|chemokine-mediated signaling pathway;GO:0071222|cellular response to lipopolysaccharide;GO:0090630|activation of GTPase activity;GO:2000545|negative regulation of endothelial cell chemotaxis to fibroblast growth factor;","GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0008009|chemokine activity;GO:0008201|heparin binding;GO:0017134|fibroblast growth factor binding;GO:0031724|CXCR5 chemokine receptor binding;GO:0031735|CCR10 chemokine receptor binding;GO:0045236|CXCR chemokine receptor binding;GO:0048018|receptor ligand activity;GO:0048248|CXCR3 chemokine receptor binding;","K10032","CXCL13; C-X-C motif chemokine 13"]
["ENSRNOG00000012681",961,80.85399317,213,13.70238333,5.900724801,2.560892175,{"v":1.97e-158,"d":"1.97E-158"},5.41E-157,"up","yes","Lgals9","protein_coding","chr10:63907018-63930045:-","gi|149053566|gb|EDM05383.1|",1769,0,"rCG33388, isoform CRA_a [Rattus norvegicus]","gi|2351552|gb|U72741.1|RNU72741",1067,0,"Rattus norvegicus 36 Kd beta-galactoside binding lectin mRNA, complete cds","P97840",682,0,"Galectin-9",".",".",".",".","pfam00337","Gal-bind_lectin","Galactoside-binding lectin. This family contains galactoside binding lectins.   The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).","GO:0001819|positive regulation of cytokine production;GO:0002519|natural killer cell tolerance induction;GO:0006811|ion transport;GO:0006954|inflammatory response;GO:0007565|female pregnancy;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0032496|response to lipopolysaccharide;GO:0032682|negative regulation of chemokine production;GO:0032689|negative regulation of interferon-gamma production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032722|positive regulation of chemokine production;GO:0032729|positive regulation of interferon-gamma production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032732|positive regulation of interleukin-1 production;GO:0032733|positive regulation of interleukin-10 production;GO:0032735|positive regulation of interleukin-12 production;GO:0032736|positive regulation of interleukin-13 production;GO:0032753|positive regulation of interleukin-4 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032815|negative regulation of natural killer cell activation;GO:0032823|regulation of natural killer cell differentiation;GO:0032834|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response;GO:0034138|toll-like receptor 3 signaling pathway;GO:0038066|p38MAPK cascade;GO:0043032|positive regulation of macrophage activation;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043305|negative regulation of mast cell degranulation;GO:0043322|negative regulation of natural killer cell degranulation;GO:0045089|positive regulation of innate immune response;GO:0045185|maintenance of protein location;GO:0045591|positive regulation of regulatory T cell differentiation;GO:0045953|negative regulation of natural killer cell mediated cytotoxicity;GO:0046007|negative regulation of activated T cell proliferation;GO:0046598|positive regulation of viral entry into host cell;GO:0050728|negative regulation of inflammatory response;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051353|positive regulation of oxidoreductase activity;GO:0060135|maternal process involved in female pregnancy;GO:0070241|positive regulation of activated T cell autonomous cell death;GO:0070371|ERK1 and ERK2 cascade;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070555|response to interleukin-1;GO:0071346|cellular response to interferon-gamma;GO:0071636|positive regulation of transforming growth factor beta production;GO:0071639|positive regulation of monocyte chemotactic protein-1 production;GO:0071902|positive regulation of protein serine/threonine kinase activity;GO:0098586|cellular response to virus;GO:1900426|positive regulation of defense response to bacterium;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:2000406|positive regulation of T cell migration;GO:2000510|positive regulation of dendritic cell chemotaxis;GO:2000562|negative regulation of CD4-positive, alpha-beta T cell proliferation;GO:2000563|positive regulation of CD4-positive, alpha-beta T cell proliferation;GO:2000670|positive regulation of dendritic cell apoptotic process;GO:2000679|positive regulation of transcription regulatory region DNA binding;GO:2001190|positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:2001200|positive regulation of dendritic cell differentiation;GO:2001269|positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0005102|signaling receptor binding;GO:0016936|galactoside binding;GO:0019899|enzyme binding;GO:0030246|carbohydrate binding;GO:0043539|protein serine/threonine kinase activator activity;GO:0048030|disaccharide binding;","K10093","LGALS9; galectin-9"]
["ENSRNOG00000012807",2454,206.4679493,1333,85.7524741,2.407720027,1.267667643,{"v":2.99e-155,"d":"2.99E-155"},{"v":8.03e-154,"d":"8.03E-154"},"up","yes","C1qa","protein_coding","chr5:149133636-149136534:-","gi|56606082|ref|NP_001008515.1|",1272,{"v":3e-169,"d":"3.00E-169"},"complement C1q subcomponent subunit A precursor [Rattus norvegicus]","gi|56606081|ref|NM_001008515.1|",975,0,"Rattus norvegicus complement component 1, q subcomponent, A chain (C1qa), mRNA","P31720",494,{"v":1e-170,"d":"1.00E-170"},"Complement C1q subcomponent subunit A",".",".",".",".","pfam00386","C1q","C1q domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.","GO:0001774|microglial cell activation;GO:0006958|complement activation, classical pathway;GO:0007568|aging;GO:0010039|response to iron ion;GO:0016322|neuron remodeling;GO:0045087|innate immune response;GO:0048143|astrocyte activation;GO:0050808|synapse organization;GO:0098883|synapse pruning;GO:0150062|complement-mediated synapse pruning;GO:0150064|vertebrate eye-specific patterning;GO:1901216|positive regulation of neuron death;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005581|collagen trimer;GO:0045202|synapse;GO:0098794|postsynapse;","GO:0003674|molecular_function;","K03986","C1QA; complement C1q subcomponent subunit A"]
["ENSRNOG00000022218",1623,136.551541,668,42.97273271,3.177632243,1.667952167,{"v":9.88e-155,"d":"9.88E-155"},{"v":2.64e-153,"d":"2.64E-153"},"up","yes","Ifi44","protein_coding","chr2:240626066-240643844:-","gi|157819749|ref|NP_001101199.1|",2131,0,"interferon-induced protein 44 [Rattus norvegicus]","gi|672044490|ref|XM_006233495.2|",1762,0,"PREDICTED: Rattus norvegicus interferon-induced protein 44 (Ifi44), transcript variant X1, mRNA","Q8BV66",610,0,"Interferon-induced protein 44",".",".",".",".","pfam07534","TLD","TLD. This domain is predicted to be an enzyme and is often found associated with pfam01476. It's structure consists of a beta-sandwich surrounded by two helices and two one-turn helices.","GO:0006955|immune response;GO:0009617|response to bacterium;","GO:0005737|cytoplasm;",".",".","."]
["ENSRNOG00000020865",2466,207.4775725,1355,87.16774374,2.380210426,1.251089123,{"v":7.3E-153,"d":"7.30E-153"},{"v":1.94e-151,"d":"1.94E-151"},"up","yes","Ano1","protein_coding","chr1:199751439-199900069:-","gi|157817235|ref|NP_001101034.1|",5275,0,"anoctamin-1 [Rattus norvegicus]","gi|157817234|ref|NM_001107564.1|",4610,0,"Rattus norvegicus anoctamin 1, calcium activated chloride channel (Ano1), mRNA","Q8BHY3",1860,0,"Anoctamin-1",".",".",".",".","pfam04547","Anoctamin","Calcium-activated chloride channel. The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.","GO:0006812|cation transport;GO:0006821|chloride transport;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0015705|iodide transport;GO:0034605|cellular response to heat;GO:0035774|positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0042391|regulation of membrane potential;GO:0050965|detection of temperature stimulus involved in sensory perception of pain;GO:0055085|transmembrane transport;GO:0060438|trachea development;GO:0098655|cation transmembrane transport;GO:1901653|cellular response to peptide;GO:1902476|chloride transmembrane transport;","GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0016324|apical plasma membrane;GO:0045121|membrane raft;","GO:0005102|signaling receptor binding;GO:0005227|calcium activated cation channel activity;GO:0005229|intracellular calcium activated chloride channel activity;GO:0005247|voltage-gated chloride channel activity;GO:0005254|chloride channel activity;GO:0015111|iodide transmembrane transporter activity;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;","K19496","ANO1, DOG1, TMEM16A; anoctamin-1"]
["ENSRNOG00000033220",547,46.02199195,28,1.801252269,25.54999804,4.675251275,1.29E-144,{"v":3.23e-143,"d":"3.23E-143"},"up","yes","Oas1k","protein_coding","chr12:35724055-35735242:-","gi|148747317|ref|NP_653353.2|",1709,0,"inactive 2'-5'-oligoadenylate synthase 1B [Rattus norvegicus]","gi|3192926|gb|AF068268.1|",2111,0,"Rattus norvegicus 2'5' oligoadenylate synthetase-2 mRNA, complete cds","Q5BKD0",662,0,"Inactive 2'-5'-oligoadenylate synthase 1B",".",".",".",".","pfam10421","OAS1_C","2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus. This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between 320 and 344 at the extreme C-terminal end. Oligoadenylate synthetases are antiviral enzymes that counteract vial attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesize 2'.5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication. This domain is often associated with NTP_transf_2 pfam01909.","GO:0009615|response to virus;GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0051607|defense response to virus;GO:0060700|regulation of ribonuclease activity;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005789|endoplasmic reticulum membrane;GO:0005829|cytosol;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0001730|2'-5'-oligoadenylate synthetase activity;GO:0003725|double-stranded RNA binding;","K14216","OAS; 2'-5'-oligoadenylate synthetase [EC:2.7.7.84]"]
["ENSRNOG00000061429",1290,108.5344966,463,29.78499288,3.643932265,1.865496142,{"v":8.39e-144,"d":"8.39E-144"},{"v":2.09e-142,"d":"2.09E-142"},"up","yes","Rph3al","protein_coding","chr10:60690031-60801883:-","gi|19424292|ref|NP_598275.1|",1431,0,"rab effector Noc2 [Rattus norvegicus]","gi|61889106|ref|NM_133591.2|",1993,0,"Rattus norvegicus rabphilin 3A-like (without C2 domains) (Rph3al), mRNA","O54880",555,0,"Rab effector Noc2",".",".",".",".","pfam02318","FYVE_2","FYVE-type zinc finger. This FYVE-type zinc finger is found at the N-terminus of effector proteins including rabphilin-3A and regulating synaptic membrane exocytosis protein 2.","GO:0006886|intracellular protein transport;GO:0006887|exocytosis;GO:0009410|response to xenobiotic stimulus;GO:0017158|regulation of calcium ion-dependent exocytosis;GO:0032024|positive regulation of insulin secretion;GO:0042593|glucose homeostasis;GO:0045744|negative regulation of G protein-coupled receptor signaling pathway;GO:0050714|positive regulation of protein secretion;","GO:0005737|cytoplasm;GO:0030141|secretory granule;GO:0030658|transport vesicle membrane;GO:0030667|secretory granule membrane;","GO:0005515|protein binding;GO:0030274|LIM domain binding;GO:0031267|small GTPase binding;GO:0046872|metal ion binding;","K19939","RPH3AL; Rab effector Noc2"]
["ENSRNOG00000066242",1081,90.95022541,324,20.84306197,4.363573141,2.12550998,{"v":5.75e-143,"d":"5.75E-143"},1.41E-141,"up","yes","Rtp4","protein_coding","chr11:77238216-77335437:-","gi|157820051|ref|NP_001101791.1|",1050,{"v":4e-139,"d":"4.00E-139"},"receptor-transporting protein 4 [Rattus norvegicus]","gi|672071410|ref|XM_006248521.2|",859,0,"PREDICTED: Rattus norvegicus receptor (chemosensory) transporter protein 4 (Rtp4), transcript variant X1, mRNA","Q9ER80",298,{"v":3e-97,"d":"3.00E-97"},"Receptor-transporting protein 4",".",".",".",".","pfam13695","zf-3CxxC","Zinc-binding domain. This is a family with several pairs of CxxC motifs possibly representing a multiple zinc-binding region. Only one pair of cysteines is associated with a highly conserved histidine residue.",".",".",".",".","."]
["ENSRNOG00000014079",2916,245.3384434,1805,116.1164409,2.112865684,1.079201057,{"v":6.78e-143,"d":"6.78E-143"},1.65E-141,"up","yes","Stat4","protein_coding","chr9:49419340-49588540:-","gi|58866024|ref|NP_001012226.1|",3624,0,"signal transducer and activator of transcription 4 [Rattus norvegicus]","gi|58866023|ref|NM_001012226.1|",2584,0,"Rattus norvegicus signal transducer and activator of transcription 4 (Stat4), mRNA","P42228",1361,0,"Signal transducer and activator of transcription 4",".",".",".",".","pfam02864","STAT_bind","STAT protein, DNA binding domain. STAT proteins (Signal Transducers and Activators of Transcription) are a family of transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors. This family represents the DNA binding domain of STAT, which has an ig-like fold. STAT proteins also include an SH2 domain pfam00017.","GO:0001937|negative regulation of endothelial cell proliferation;GO:0002230|positive regulation of defense response to virus by host;GO:0006351|transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006468|protein phosphorylation;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006952|defense response;GO:0007259|JAK-STAT cascade;GO:0007584|response to nutrient;GO:0008015|blood circulation;GO:0008150|biological_process;GO:0008283|cell proliferation;GO:0008284|positive regulation of cell proliferation;GO:0009410|response to xenobiotic stimulus;GO:0009612|response to mechanical stimulus;GO:0009617|response to bacterium;GO:0010628|positive regulation of gene expression;GO:0010742|macrophage derived foam cell differentiation;GO:0014070|response to organic cyclic compound;GO:0016525|negative regulation of angiogenesis;GO:0019221|cytokine-mediated signaling pathway;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0032496|response to lipopolysaccharide;GO:0032727|positive regulation of interferon-alpha production;GO:0032869|cellular response to insulin stimulus;GO:0033209|tumor necrosis factor-mediated signaling pathway;GO:0034097|response to cytokine;GO:0034240|negative regulation of macrophage fusion;GO:0034340|response to type I interferon;GO:0035456|response to interferon-beta;GO:0035458|cellular response to interferon-beta;GO:0042127|regulation of cell proliferation;GO:0042542|response to hydrogen peroxide;GO:0043124|negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043330|response to exogenous dsRNA;GO:0043434|response to peptide hormone;GO:0045648|positive regulation of erythrocyte differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046725|negative regulation by virus of viral protein levels in host cell;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0051591|response to cAMP;GO:0051607|defense response to virus;GO:0051770|positive regulation of nitric-oxide synthase biosynthetic process;GO:0060333|interferon-gamma-mediated signaling pathway;GO:0060337|type I interferon signaling pathway;GO:0061326|renal tubule development;GO:0061484|hematopoietic stem cell homeostasis;GO:0070106|interleukin-27-mediated signaling pathway;GO:0071222|cellular response to lipopolysaccharide;GO:0071310|cellular response to organic substance;GO:0071345|cellular response to cytokine stimulus;GO:0071346|cellular response to interferon-gamma;GO:0071407|cellular response to organic cyclic compound;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0030424|axon;GO:0030425|dendrite;GO:0032991|protein-containing complex;GO:0048471|perinuclear region of cytoplasm;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000979|RNA polymerase II core promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001222|transcription corepressor binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003690|double-stranded DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0005164|tumor necrosis factor receptor binding;GO:0016922|nuclear receptor binding;GO:0019899|enzyme binding;GO:0031730|CCR5 chemokine receptor binding;GO:0035035|histone acetyltransferase binding;GO:0042393|histone binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0043565|sequence-specific DNA binding;GO:0044389|ubiquitin-like protein ligase binding;GO:0051721|protein phosphatase 2A binding;GO:1990841|promoter-specific chromatin binding;","K11220","STAT1; signal transducer and activator of transcription 1K11220; K11222"]
["ENSRNOG00000002217",517,43.49793389,20,1.286608764,33.80820582,5.07930155,{"v":2.6e-140,"d":"2.60E-140"},{"v":6.26e-139,"d":"6.26E-139"},"up","yes","Plac8","protein_coding","chr14:9063048-9074264:+","gi|157820945|ref|NP_001101823.1|",517,{"v":8e-64,"d":"8.00E-64"},"placenta-specific gene 8 protein [Rattus norvegicus]","gi|157820944|ref|NM_001108353.1|",605,0,"Rattus norvegicus placenta-specific 8 (Plac8), mRNA","Q9JI48",202,{"v":1e-64,"d":"1.00E-64"},"Placenta-specific gene 8 protein",".",".",".",".","pfam04749","PLAC8","PLAC8 family. This family includes the Placenta-specific gene 8 protein.","GO:0008284|positive regulation of cell proliferation;GO:0009409|response to cold;GO:0040015|negative regulation of multicellular organism growth;GO:0042742|defense response to bacterium;GO:0043066|negative regulation of apoptotic process;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050873|brown fat cell differentiation;GO:0120162|positive regulation of cold-induced thermogenesis;",".","GO:0003682|chromatin binding;",".","."]
["ENSRNOG00000006314",515,43.32966335,20,1.286608764,33.67741972,5.073709702,{"v":9.69e-140,"d":"9.69E-140"},{"v":2.31e-138,"d":"2.31E-138"},"up","yes","Zbp1","protein_coding","chr3:161993351-162003870:-","gi|449310782|ref|NP_598248.1|",1880,0,"Z-DNA-binding protein 1 [Rattus norvegicus]","gi|672047961|ref|XM_006235674.2|",1856,0,"PREDICTED: Rattus norvegicus Z-DNA binding protein 1 (Zbp1), transcript variant X1, mRNA","Q8VDA5",727,0,"Z-DNA-binding protein 1",".",".",".",".","pfam12721","RHIM","RIP homotypic interaction motif. RIP proteins are receptor-interacting serine/threonine-protein kinases or cell death proteins. This interacting domain is involved in virus recognition. The RHIM domain is necessary for the recruitment of RIP and RIP3 by the IFN-inducible protein DNA-dependent activator of IRFs (DAI), also known as DLM-1 or Z-DNA binding protein (ZBP1). Both the RIP kinases contribute to DAI-induced NF-kappaB activation. RIP3 undergoes auto phosphorylation on binding to DAI.","GO:0002218|activation of innate immune response;GO:0006915|apoptotic process;GO:0043065|positive regulation of apoptotic process;GO:0045087|innate immune response;GO:0050727|regulation of inflammatory response;GO:0050729|positive regulation of inflammatory response;GO:0051607|defense response to virus;GO:0060340|positive regulation of type I interferon-mediated signaling pathway;GO:0060545|positive regulation of necroptotic process;GO:0070269|pyroptosis;GO:2000659|regulation of interleukin-1-mediated signaling pathway;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0003677|DNA binding;GO:0003692|left-handed Z-DNA binding;GO:0003723|RNA binding;GO:0003725|double-stranded RNA binding;GO:0003726|double-stranded RNA adenosine deaminase activity;GO:0042802|identical protein binding;","K12965","ZBP1, DAI; Z-DNA binding protein 1"]
["ENSRNOG00000037563",1652,138.9914638,749,48.1834982,2.884627912,1.528385238,{"v":5.27e-139,"d":"5.27E-139"},1.25E-137,"up","yes","Cd68","protein_coding","chr10:54381815-54383697:-","gi|72255507|ref|NP_001026808.1|",1022,{"v":2e-133,"d":"2.00E-133"},"macrosialin precursor [Rattus norvegicus]","gi|72255506|ref|NM_001031638.1|",1107,0,"Rattus norvegicus Cd68 molecule (Cd68), mRNA","P31996",348,{"v":1e-115,"d":"1.00E-115"},"Macrosialin",".",".",".",".","pfam01299","Lamp","Lysosome-associated membrane glycoprotein (Lamp).","GO:0002437|inflammatory response to antigenic stimulus;GO:0002605|negative regulation of dendritic cell antigen processing and presentation;GO:0007568|aging;GO:0031669|cellular response to nutrient levels;GO:0035425|autocrine signaling;GO:0071222|cellular response to lipopolysaccharide;GO:0071310|cellular response to organic substance;GO:0072594|establishment of protein localization to organelle;GO:0140052|cellular response to oxidised low-density lipoprotein particle stimulus;","GO:0005764|lysosome;GO:0005765|lysosomal membrane;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0031902|late endosome membrane;",".","K06501","CD68; CD68 antigen"]
["ENSRNOG00000042620",1721,144.7967973,812,52.23631581,2.771956542,1.47090464,{"v":7.46e-137,"d":"7.46E-137"},1.74E-135,"up","yes","Marveld1","protein_coding","chr1:240954452-240958384:+","gi|157820241|ref|NP_001101060.1|",372,{"v":2e-38,"d":"2.00E-38"},"MARVEL domain-containing protein 1 [Rattus norvegicus]","gi|157820240|ref|NM_001107590.1|",2772,0,"Rattus norvegicus MARVEL domain containing 1 (Marveld1), mRNA","Q7TQJ1",99.4,{"v":6e-22,"d":"6.00E-22"},"MARVEL domain-containing protein 1",".",".",".",".","pfam09310","PD-C2-AF1","POU domain, class 2, associating factor 1. Members of this family are transcriptional coactivators that specifically associate with either OCT1 or OCT2, through recognition of their POU domains. They are essential for the response of B-cells to antigens and required for the formation of germinal centres.",".",".",".",".","."]
["ENSRNOG00000020991",585,49.21913216,63,4.052817606,12.1444232,3.602222066,{"v":2.46e-133,"d":"2.46E-133"},{"v":5.55e-132,"d":"5.55E-132"},"up","yes","Ms4a6a","protein_coding","chr1:208401466-208414758:-","gi|672014692|ref|XP_001075502.5|",1073,{"v":2E-137,"d":"2.00E-137"},"PREDICTED: membrane-spanning 4-domains subfamily A member 6D [Rattus norvegicus]","gi|672014691|ref|XM_001075502.5|",2442,0,"PREDICTED: Rattus norvegicus membrane-spanning 4-domains, subfamily A, member 6A (Ms4a6a), mRNA","Q99N07",316,{"v":9e-100,"d":"9.00E-100"},"Membrane-spanning 4-domains subfamily A member 6D",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.",".","GO:0005802|trans-Golgi network;GO:0016021|integral component of membrane;",".","K22191","MS4A5_6_7; membrane-spanning 4-domains subfamily A member 5/6/7"]
["ENSRNOG00000050697",2765,232.6340178,1735,111.6133103,2.084285622,1.059552992,1.17E-131,{"v":2.6e-130,"d":"2.60E-130"},"up","yes","Ctsz","protein_coding","chr3:163224875-163235645:-","gi|149029991|gb|EDL85083.1|",1101,{"v":1E-142,"d":"1.00E-142"},"cathepsin Z, isoform CRA_a [Rattus norvegicus]","gi|60688148|gb|BC091110.1|",965,0,"Rattus norvegicus cathepsin Z, mRNA (cDNA clone MGC:108536 IMAGE:7379777), complete cds","Q9R1T3",426,{"v":1E-141,"d":"1.00E-141"},"Cathepsin Z",".",".",".",".","pfam00112","Peptidase_C1","Papain family cysteine protease.","GO:0006508|proteolysis;GO:0010757|negative regulation of plasminogen activation;GO:0010977|negative regulation of neuron projection development;GO:0032091|negative regulation of protein binding;GO:0043525|positive regulation of neuron apoptotic process;GO:0051603|proteolysis involved in cellular protein catabolic process;GO:0060441|epithelial tube branching involved in lung morphogenesis;GO:1901214|regulation of neuron death;GO:2000179|positive regulation of neural precursor cell proliferation;","GO:0005615|extracellular space;GO:0005764|lysosome;GO:0005783|endoplasmic reticulum;GO:0009986|cell surface;GO:0030426|growth cone;GO:0031410|cytoplasmic vesicle;","GO:0004180|carboxypeptidase activity;GO:0004197|cysteine-type endopeptidase activity;","K08568","CTSZ; cathepsin X [EC:3.4.18.1]"]
["ENSRNOG00000017512",2023,170.2056485,1084,69.73419499,2.440777419,1.287340738,{"v":2.12e-131,"d":"2.12E-131"},{"v":4.69e-130,"d":"4.69E-130"},"up","yes","Aldh3b1","protein_coding","chr1:201145309-201163921:-","gi|55742838|ref|NP_001006999.1|",2518,0,"aldehyde dehydrogenase family 3 member B1 [Rattus norvegicus]","gi|672039352|ref|XM_008760134.1|",1832,0,"PREDICTED: Rattus norvegicus aldehyde dehydrogenase 3 family, member B1 (Aldh3b1), transcript variant X4, mRNA","Q5XI42",974,0,"Aldehyde dehydrogenase family 3 member B1","alr3672",460,{"v":1e-154,"d":"1.00E-154"},"COG1012","pfam00171","Aldedh","Aldehyde dehydrogenase family. This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:1.2.1.3. Succinate-semialdehyde dehydrogenase EC:1.2.1.16. Lactaldehyde dehydrogenase EC:1.2.1.22. Benzaldehyde dehydrogenase EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase EC: 1.5.1.12. Acetaldehyde dehydrogenase EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase EC:1.2.1.41. This family also includes omega crystallin, an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.","GO:0006068|ethanol catabolic process;GO:0006081|cellular aldehyde metabolic process;GO:0006979|response to oxidative stress;GO:0034599|cellular response to oxidative stress;GO:0046185|aldehyde catabolic process;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0004029|aldehyde dehydrogenase (NAD) activity;GO:0004030|aldehyde dehydrogenase [NAD(P)+] activity;GO:0016620|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor;GO:0018477|benzaldehyde dehydrogenase (NADP+) activity;GO:0018479|benzaldehyde dehydrogenase (NAD+) activity;","K00129","ALDH3; aldehyde dehydrogenase (NAD(P)+) [EC:1.2.1.5]"]
["ENSRNOG00000060381",1042,87.66894993,332,21.35770548,4.104792531,2.037309306,1.03E-130,{"v":2.26e-129,"d":"2.26E-129"},"up","yes","Col15a1","protein_coding","chr5:61501963-61607591:+","gi|407228400|ref|NP_001094005.1|",4836,0,"collagen alpha-1(XV) chain precursor [Rattus norvegicus]","gi|672052583|ref|XM_003749933.3|",5190,0,"PREDICTED: Rattus norvegicus collagen alpha-1(XV) chain-like (LOC100909752), mRNA","O35206",1653,0,"Collagen alpha-1(XV) chain",".",".",".",".","pfam06482","Endostatin","Collagenase NC10 and Endostatin. NC10 stands for Non-helical region 10 and is taken from human COL15A1. A mutation in this region in human COL18A1 is associated with an increased risk of prostrate cancer. This domain is cleaved from the precursor and forms endostatin. Endostatin is a key tumor suppressor and has been used highly successfully to treat cancer. It is a potent angiogenesis inhibitor. Endostatin also binds a zinc ion near the N-terminus; this is likely to be of structural rather than functional importance.","GO:0001525|angiogenesis;GO:0001886|endothelial cell morphogenesis;GO:0030198|extracellular matrix organization;","GO:0005581|collagen trimer;GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0031012|extracellular matrix;","GO:0005201|extracellular matrix structural constituent;","K08135","COL15A; collagen type XV alpha"]
["ENSRNOG00000037371",688,57.88506483,120,7.719652582,7.498402838,2.906583334,{"v":5.56e-130,"d":"5.56E-130"},{"v":1.21e-128,"d":"1.21E-128"},"up","yes","Xaf1","protein_coding","chr10:56917121-56929770:+","gi|564312948|ref|XP_006220783.1|",1492,0,"PREDICTED: XIAP-associated factor 1 [Rattus norvegicus]","gi|672024934|ref|XM_006220721.2|",1665,0,"PREDICTED: Rattus norvegicus XIAP associated factor-1 (XAF1), mRNA","Q5NBU8",441,{"v":7e-149,"d":"7.00E-149"},"XIAP-associated factor 1",".",".",".",".","pfam12230","PRP21_like_P","Pre-mRNA splicing factor PRP21 like protein. This domain family is found in eukaryotes, and is typically between 212 and 238 amino acids in length. The family is found in association with pfam01805. There are two completely conserved residues (W and H) that may be functionally important. PRP21 is required for assembly of the prespliceosome and it interacts with U2 snRNP and/or pre-mRNA in the prespliceosome. This family also contains proteins similar to PRP21, such as the mammalian SF3a. SF3a also interacts with U2 snRNP from the prespliceosome, converting it to its active form.","GO:0006915|apoptotic process;GO:0031333|negative regulation of protein complex assembly;GO:0035456|response to interferon-beta;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005739|mitochondrion;","GO:0005515|protein binding;",".","."]
["ENSRNOG00000018247",635,53.42589559,94,6.047061189,8.835018188,3.143233105,{"v":2.91e-129,"d":"2.91E-129"},{"v":6.29e-128,"d":"6.29E-128"},"up","yes","Dhx58","protein_coding","chr10:85620357-85631525:-","gi|149408137|ref|NP_001092258.1|",3585,0,"probable ATP-dependent RNA helicase DHX58 [Rattus norvegicus]","gi|672068688|ref|XM_006247315.2|",2373,0,"PREDICTED: Rattus norvegicus DEXH (Asp-Glu-X-His) box polypeptide 58 (Dhx58), transcript variant X2, mRNA","Q99J87",1266,0,"Probable ATP-dependent RNA helicase DHX58","TVN1490",130,{"v":5e-31,"d":"5.00E-31"},"COG1111","pfam11648","RIG-I_C-RD","C-terminal domain of RIG-I. This family of proteins represents the regulatory domain RD of RIG-I, a protein which initiates a signalling cascade that provides essential antiviral protection for the host. The RD domain binds viral RNA, activating the RIG-I ATPase by RNA-dependant dimerization. The structure of RD contains a zinc-binding domain and is thought to confer ligand specificity.","GO:0009615|response to virus;GO:0009617|response to bacterium;GO:0032480|negative regulation of type I interferon production;GO:0032481|positive regulation of type I interferon production;GO:0032728|positive regulation of interferon-beta production;GO:0039534|negative regulation of MDA-5 signaling pathway;GO:0039536|negative regulation of RIG-I signaling pathway;GO:0045087|innate immune response;GO:0045088|regulation of innate immune response;GO:0045824|negative regulation of innate immune response;GO:0051607|defense response to virus;GO:1900245|positive regulation of MDA-5 signaling pathway;GO:1900246|positive regulation of RIG-I signaling pathway;","GO:0005737|cytoplasm;","GO:0003677|DNA binding;GO:0003724|RNA helicase activity;GO:0003725|double-stranded RNA binding;GO:0003727|single-stranded RNA binding;GO:0005524|ATP binding;GO:0008270|zinc ion binding;","K12649","DHX58, LGP2; ATP-dependent RNA helicase DHX58 [EC:3.6.4.13]"]
["ENSRNOG00000042139",606,50.9859728,80,5.146435055,9.907046773,3.308455063,{"v":4.59e-129,"d":"4.59E-129"},{"v":9.87e-128,"d":"9.87E-128"},"up","yes","Clec4a1","protein_coding","chr4:156173894-156186008:+","gi|54312106|ref|NP_001005890.1|",1120,{"v":4E-150,"d":"4.00E-150"},"C-type lectin domain family 4, member A1 [Rattus norvegicus]","gi|70778852|ref|NM_001005890.2|",1199,0,"Rattus norvegicus C-type lectin domain family 4, member A1 (Clec4a1), mRNA","Q9UMR7",201,{"v":3e-60,"d":"3.00E-60"},"C-type lectin domain family 4 member A",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type",".","GO:0016021|integral component of membrane;","GO:0030246|carbohydrate binding;","K10057","CLEC4A, CD367; C-type lectin domain family 4 member A"]
["ENSRNOG00000022242",1560,131.2510191,718,46.18925462,2.841592058,1.506699455,1.12E-128,{"v":2.4e-127,"d":"2.40E-127"},"up","yes","Cxcl9","protein_coding","chr14:15722908-15728435:+","gi|21728396|ref|NP_663705.1|",558,{"v":3e-67,"d":"3.00E-67"},"C-X-C motif chemokine 9 precursor [Rattus norvegicus]","gi|56541235|gb|BC087594.1|",1159,0,"Rattus norvegicus chemokine (C-X-C motif) ligand 9, mRNA (cDNA clone MGC:105312 IMAGE:7310193), complete cds","P18340",166,{"v":2e-48,"d":"2.00E-48"},"C-X-C motif chemokine 9",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0009617|response to bacterium;GO:0030593|neutrophil chemotaxis;GO:0031640|killing of cells of other organism;GO:0042127|regulation of cell proliferation;GO:0045663|positive regulation of myoblast differentiation;GO:0050930|induction of positive chemotaxis;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;GO:0051607|defense response to virus;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098|chemokine-mediated signaling pathway;GO:0071222|cellular response to lipopolysaccharide;GO:1901741|positive regulation of myoblast fusion;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0009897|external side of plasma membrane;","GO:0008009|chemokine activity;GO:0045236|CXCR chemokine receptor binding;GO:0048248|CXCR3 chemokine receptor binding;","K05416","CXCL9; C-X-C motif chemokine 9"]
["ENSRNOG00000024382",577,48.54605001,68,4.374469797,11.09758491,3.472173842,{"v":6.65e-128,"d":"6.65E-128"},1.42E-126,"up","yes","Fcgr3a","protein_coding","chr13:83249872-83259921:+","gi|672074776|ref|XP_008767961.1|",1276,{"v":3e-173,"d":"3.00E-173"},"PREDICTED: Fc fragment of IgG, low affinity IIIa, receptor isoform X1 [Rattus norvegicus]","gi|672074775|ref|XM_008769739.1|",1111,0,"PREDICTED: Rattus norvegicus Fc fragment of IgG, low affinity IIIa, receptor (Fcgr3a), transcript variant X1, mRNA","A0A0B4J1G0",409,{"v":1e-140,"d":"1.00E-140"},"Low affinity immunoglobulin gamma Fc region receptor IV",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0007166|cell surface receptor signaling pathway;GO:0038094|Fc-gamma receptor signaling pathway;GO:0038095|Fc-epsilon receptor signaling pathway;GO:0042060|wound healing;GO:0042119|neutrophil activation;GO:0045780|positive regulation of bone resorption;GO:0050776|regulation of immune response;GO:0051930|regulation of sensory perception of pain;GO:0071222|cellular response to lipopolysaccharide;","GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;","GO:0003674|molecular_function;GO:0004888|transmembrane signaling receptor activity;GO:0019767|IgE receptor activity;GO:0019770|IgG receptor activity;","K06463","FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III"]
["ENSRNOG00000029145",845,71.09430201,216,13.89537465,5.116400515,2.355129204,6.18E-127,{"v":1.31e-125,"d":"1.31E-125"},"up","yes","AY172581.2","Mt_tRNA","chrMT:15348-15415:-",".",".",".",".","gi|755572967|gb|KP244683.1|",68,{"v":2e-26,"d":"2.00E-26"},"Rattus norvegicus isolate 115 mitochondrion, complete genome",".",".",".",".",".",".",".",".","pfam02514","CobN-Mg_chel","CobN/Magnesium Chelatase. This family contains a domain common to the cobN protein and to magnesium protoporphyrin chelatase. CobN is implicated in the conversion of hydrogenobyrinic acid a,c-diamide to cobyrinic acid. Magnesium protoporphyrin chelatase is involved in chlorophyll biosynthesis.",".",".",".",".","."]
["ENSRNOG00000011483",530,44.59169238,48,3.087861033,14.44096477,3.852095223,{"v":8.84e-127,"d":"8.84E-127"},1.85E-125,"up","yes","S100a9","protein_coding","chr2:176190361-176193230:-","gi|564337450|ref|XP_006232842.1|",706,{"v":8e-92,"d":"8.00E-92"},"PREDICTED: protein S100-A9 isoform X1 [Rattus norvegicus]","gi|564337449|ref|XM_006232780.1|",576,0,"PREDICTED: Rattus norvegicus S100 calcium binding protein A9 (S100a9), transcript variant X1, mRNA","P50116",237,{"v":4E-78,"d":"4.00E-78"},"Protein S100-A9",".",".",".",".","pfam01023","S_100","S-100/ICaBP type calcium binding domain. The S-100 domain is a subfamily of the EF-hand calcium binding proteins.","GO:0002523|leukocyte migration involved in inflammatory response;GO:0002544|chronic inflammatory response;GO:0002793|positive regulation of peptide secretion;GO:0006417|regulation of translation;GO:0006914|autophagy;GO:0006915|apoptotic process;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0010043|response to zinc ion;GO:0010976|positive regulation of neuron projection development;GO:0014002|astrocyte development;GO:0018119|peptidyl-cysteine S-nitrosylation;GO:0030194|positive regulation of blood coagulation;GO:0030593|neutrophil chemotaxis;GO:0030595|leukocyte chemotaxis;GO:0031532|actin cytoskeleton reorganization;GO:0032496|response to lipopolysaccharide;GO:0035425|autocrine signaling;GO:0035606|peptidyl-cysteine S-trans-nitrosylation;GO:0035821|modification of morphology or physiology of other organism;GO:0045087|innate immune response;GO:0045113|regulation of integrin biosynthetic process;GO:0045471|response to ethanol;GO:0050729|positive regulation of inflammatory response;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070488|neutrophil aggregation;GO:0098869|cellular oxidant detoxification;GO:2001244|positive regulation of intrinsic apoptotic signaling pathway;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0030054|cell junction;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;GO:0016209|antioxidant activity;GO:0048306|calcium-dependent protein binding;","K21128","S100A9; protein S100-A9"]
["ENSRNOG00000007457",2491,209.5809542,1518,97.65360516,2.146167096,1.101762406,1.83E-126,{"v":3.78e-125,"d":"3.78E-125"},"up","yes","Serping1","protein_coding","chr3:69842739-69852034:-","gi|40018558|ref|NP_954524.1|",2362,0,"plasma protease C1 inhibitor precursor [Rattus norvegicus]","gi|40018557|ref|NM_199093.1|",1783,0,"Rattus norvegicus serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 (Serping1), mRNA","Q6P734",914,0,"Plasma protease C1 inhibitor","MA3388",91.3,{"v":7e-19,"d":"7.00E-19"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0001869|negative regulation of complement activation, lectin pathway;GO:0006958|complement activation, classical pathway;GO:0007568|aging;GO:0007596|blood coagulation;GO:0010951|negative regulation of endopeptidase activity;GO:0042730|fibrinolysis;GO:0045087|innate immune response;","GO:0005615|extracellular space;","GO:0001848|complement binding;GO:0003674|molecular_function;GO:0004867|serine-type endopeptidase inhibitor activity;","K04001","SERPING1, C1INH; C1 inhibitor"]
["ENSRNOG00000054493",499,41.98349905,35,2.251565336,18.64636055,4.220822163,{"v":3.97e-126,"d":"3.97E-126"},{"v":8.18e-125,"d":"8.18E-125"},"up","yes","Rpph1","ribozyme","chr15:24033662-24033959:-","gi|426376198|ref|XP_004054894.1|",150,{"v":1E-10,"d":"1.00E-10"},"PREDICTED: uncharacterized protein LOC101140100 [Gorilla gorilla gorilla]","gi|157742930|gb|BC116202.1|",256,{"v":4e-130,"d":"4.00E-130"},"Mus musculus cDNA clone IMAGE:40090112",".",".",".",".",".",".",".",".","pfam03362","Herpes_UL47","Herpesvirus UL47 protein.","GO:0008150|biological_process;","GO:0005575|cellular_component;","GO:0003674|molecular_function;",".","."]
["ENSRNOG00000003622",656,55.19273623,112,7.205009077,7.66032848,2.937406257,{"v":2.63e-125,"d":"2.63E-125"},{"v":5.37e-124,"d":"5.37E-124"},"up","yes","ENSRNOG00000003622","protein_coding","chrX:13359430-13392586:-","gi|16876540|gb|AAG31606.3|AF298656_1",2861,0,"NADPH oxidase beta subunit gp91phox [Rattus norvegicus]","gi|298891875|emb|FQ217794.1|",2923,0,"Rattus norvegicus TL0ACA17YL01 mRNA sequence","Q61093",1075,0,"Cytochrome b-245 heavy chain",".",".",".",".","pfam08030","NAD_binding_6","Ferric reductase NAD binding domain.","GO:0006801|superoxide metabolic process;GO:0006952|defense response;GO:0006954|inflammatory response;GO:0007584|response to nutrient;GO:0009410|response to xenobiotic stimulus;GO:0022900|electron transport chain;GO:0032760|positive regulation of tumor necrosis factor production;GO:0042554|superoxide anion generation;GO:0045087|innate immune response;GO:0045730|respiratory burst;GO:0045766|positive regulation of angiogenesis;GO:0050665|hydrogen peroxide biosynthetic process;GO:0071276|cellular response to cadmium ion;GO:0071361|cellular response to ethanol;GO:0071456|cellular response to hypoxia;GO:0097411|hypoxia-inducible factor-1alpha signaling pathway;GO:1904044|response to aldosterone;GO:1904845|cellular response to L-glutamine;GO:1990776|response to angiotensin;","GO:0005635|nuclear envelope;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005791|rough endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0030425|dendrite;GO:0043020|NADPH oxidase complex;GO:0043025|neuronal cell body;GO:0045335|phagocytic vesicle;GO:0097038|perinuclear endoplasmic reticulum;","GO:0005515|protein binding;GO:0009055|electron transfer activity;GO:0016175|superoxide-generating NADPH oxidase activity;GO:0020037|heme binding;GO:0046982|protein heterodimerization activity;GO:0050660|flavin adenine dinucleotide binding;","K21421","NOX2, GP91, CYBB; NADPH oxidase 2 [EC:1.-.-.-]"]
["ENSRNOG00000045560",568,47.78883259,68,4.374469797,10.92448567,3.449493453,2.72E-125,{"v":5.54e-124,"d":"5.54E-124"},"up","yes","Gvin1","protein_coding","chr1:160277126-160306331:-","gi|109462622|ref|XP_001075550.1|",12947,0,"PREDICTED: interferon-induced very large GTPase 1-like isoform X1 [Rattus norvegicus]","gi|672014119|ref|XM_001075550.3|",7833,0,"PREDICTED: Rattus norvegicus similar to very large inducible GTPase 1 isoform A (LOC499229), transcript variant X1, mRNA","Q80SU7",4170,0,"Interferon-induced very large GTPase 1",".",".",".",".","pfam05879","RHD3","Root hair defective 3 GTP-binding protein (RHD3). This family consists of several eukaryotic root hair defective 3 like GTP-binding proteins. It has been speculated that the RHD3 protein is a member of a novel class of GTP-binding proteins that is widespread in eukaryotes and required for regulated cell enlargement. The family also contains the homologous yeast synthetic enhancement of YOP1 (SEY1) protein which is involved in membrane trafficking.",".","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0005525|GTP binding;",".","."]
["ENSRNOG00000019542",1317,110.8061488,546,35.12441925,3.154675612,1.657491664,{"v":7.88e-125,"d":"7.88E-125"},{"v":1.59e-123,"d":"1.59E-123"},"up","yes","MGC108823","protein_coding","chr18:53748631-53772834:+","gi|59891429|ref|NP_001012353.1|",2134,0,"uncharacterized protein LOC307414 [Rattus norvegicus]","gi|564320684|ref|XM_006222578.1|",1851,0,"PREDICTED: Rattus norvegicus interferon-inducible GTPase 1-like (LOC102549198), mRNA","Q9QZ85",606,0,"Interferon-inducible GTPase 1",".",".",".",".","pfam05049","IIGP","Interferon-inducible GTPase (IIGP). Interferon-inducible GTPase (IIGP) is thought to play a role in in intracellular defence. IIGP is predominantly associated with the Golgi apparatus and also localizes to the endoplasmic reticulum and exerts a distinct role in IFN-induced intracellular membrane trafficking or processing.","GO:0006952|defense response;GO:0035458|cellular response to interferon-beta;","GO:0005789|endoplasmic reticulum membrane;GO:0016020|membrane;","GO:0003924|GTPase activity;GO:0005525|GTP binding;",".","."]
["ENSRNOG00000008409",831,69.91640825,214,13.76671377,5.078656345,2.344446855,{"v":3.33e-124,"d":"3.33E-124"},{"v":6.63e-123,"d":"6.63E-123"},"up","yes","Myo1f","protein_coding","chr7:14363350-14413911:+","gi|157821107|ref|NP_001101546.1|",5505,0,"myosin-If [Rattus norvegicus]","gi|157821106|ref|NM_001108076.1|",3361,0,"Rattus norvegicus myosin IF (Myo1f), mRNA","O00160",2027,0,"Unconventional myosin-If","YMR109w",761,0,"COG5022","pfam00063","Myosin_head","Myosin head (motor domain).","GO:0002446|neutrophil mediated immunity;GO:0007015|actin filament organization;GO:0007162|negative regulation of cell adhesion;GO:0009617|response to bacterium;GO:0030050|vesicle transport along actin filament;GO:0030335|positive regulation of cell migration;GO:0032956|regulation of actin cytoskeleton organization;GO:0043312|neutrophil degranulation;GO:0045088|regulation of innate immune response;GO:0050830|defense response to Gram-positive bacterium;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005902|microvillus;GO:0015629|actin cytoskeleton;GO:0016459|myosin complex;GO:0030864|cortical actin cytoskeleton;GO:0031941|filamentous actin;GO:0031982|vesicle;","GO:0000146|microfilament motor activity;GO:0005516|calmodulin binding;GO:0005524|ATP binding;GO:0051015|actin filament binding;","K10356","MYO1; myosin I"]
["ENSRNOG00000007690",472,39.7118468,26,1.672591393,23.74270666,4.569412506,{"v":6.03e-124,"d":"6.03E-124"},1.19E-122,"up","yes","Cmpk2","protein_coding","chr6:43073796-43085183:+","gi|564355517|ref|XP_006240000.1|",2101,0,"PREDICTED: UMP-CMP kinase 2, mitochondrial isoform X1 [Rattus norvegicus]","gi|672055803|ref|XM_006239938.2|",3639,0,"PREDICTED: Rattus norvegicus cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial (Cmpk2), transcript variant X1, mRNA","Q3U5Q7",751,0,"UMP-CMP kinase 2, mitochondrial",".",".",".",".","pfam02223","Thymidylate_kin","Thymidylate kinase.","GO:0006165|nucleoside diphosphate phosphorylation;GO:0006227|dUDP biosynthetic process;GO:0006233|dTDP biosynthetic process;GO:0006235|dTTP biosynthetic process;GO:0009142|nucleoside triphosphate biosynthetic process;GO:0046940|nucleoside monophosphate phosphorylation;GO:0071222|cellular response to lipopolysaccharide;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005739|mitochondrion;","GO:0004127|cytidylate kinase activity;GO:0004550|nucleoside diphosphate kinase activity;GO:0004798|thymidylate kinase activity;GO:0009041|uridylate kinase activity;GO:0033862|UMP kinase activity;","K13809","CMPK2; UMP-CMP kinase 2, mitochondrial [EC:2.7.4.14]"]
["ENSRNOG00000008000",1501,126.2870382,697,44.83831541,2.81649828,1.49390259,2.35E-122,4.59E-121,"up","yes","Syt13","protein_coding","chr3:78877114-78917392:+","gi|11119239|gb|AAG30575.1|AF313453_1",1852,0,"synaptotagmin 13 [Rattus norvegicus]","gi|672046319|ref|XM_008762036.1|",3118,0,"PREDICTED: Rattus norvegicus synaptotagmin XIII (Syt13), transcript variant X1, mRNA","Q925B5",717,0,"Synaptotagmin-13",".",".",".",".","pfam00168","C2","C2 domain.","GO:0006906|vesicle fusion;GO:0014059|regulation of dopamine secretion;GO:0016192|vesicle-mediated transport;GO:0017156|calcium ion regulated exocytosis;GO:0017158|regulation of calcium ion-dependent exocytosis;GO:0071277|cellular response to calcium ion;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0030133|transport vesicle;GO:0030424|axon;GO:0043231|intracellular membrane-bounded organelle;GO:0045202|synapse;GO:0070382|exocytic vesicle;","GO:0000149|SNARE binding;GO:0001786|phosphatidylserine binding;GO:0005509|calcium ion binding;GO:0005544|calcium-dependent phospholipid binding;GO:0030276|clathrin binding;","K19913","SYT13; synaptotagmin-13"]
["ENSRNOG00000047606",530,44.59169238,56,3.602504538,12.3779698,3.629702802,{"v":1.15e-121,"d":"1.15E-121"},{"v":2.24e-120,"d":"2.24E-120"},"up","yes","Bcl2a1","protein_coding","chr8:89716914-89724998:+","gi|149018936|gb|EDL77577.1|",933,{"v":2E-125,"d":"2.00E-125"},"B-cell leukemia/lymphoma 2 related protein A1 [Rattus norvegicus]","gi|19173783|ref|NM_133416.1|",696,0,"Rattus norvegicus BCL2-related protein A1 (Bcl2a1), mRNA","Q07440",325,{"v":5e-112,"d":"5.00E-112"},"Bcl-2-related protein A1",".",".",".",".","pfam00452","Bcl-2","Apoptosis regulator proteins, Bcl-2 family.","GO:0006915|apoptotic process;GO:0007568|aging;GO:0008630|intrinsic apoptotic signaling pathway in response to DNA damage;GO:0021987|cerebral cortex development;GO:0043066|negative regulation of apoptotic process;GO:0097192|extrinsic apoptotic signaling pathway in absence of ligand;","GO:0005575|cellular_component;GO:0005741|mitochondrial outer membrane;","GO:0042803|protein homodimerization activity;GO:0044877|protein-containing complex binding;GO:0046982|protein heterodimerization activity;GO:0051400|BH domain binding;","K02162","BCL2A1; hematopoietic Bcl-2-related protein A1"]
["ENSRNOG00000023410",512,43.07725755,48,3.087861033,13.95051691,3.802246674,{"v":1.73e-121,"d":"1.73E-121"},3.34E-120,"up","yes","Apol9a","protein_coding","chr7:109140871-109147649:-","gi|68163567|ref|NP_001020237.1|",1533,0,"apolipoprotein L 9a [Rattus norvegicus]","gi|68163566|ref|NM_001025066.1|",1568,0,"Rattus norvegicus apolipoprotein L 9a (Apol9a), mRNA","O95236",162,{"v":1E-42,"d":"1.00E-42"},"Apolipoprotein L3",".",".",".",".","pfam05461","ApoL","Apolipoprotein L. Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.","GO:0006869|lipid transport;GO:0042157|lipoprotein metabolic process;","GO:0005576|extracellular region;","GO:0008289|lipid binding;","K14480","APOL; apolipoprotein L"]
["ENSRNOG00000065208",481,40.46906422,35,2.251565336,17.97374634,4.167819242,{"v":7.95e-121,"d":"7.95E-121"},{"v":1.52e-119,"d":"1.52E-119"},"up","yes","ENSRNOG00000065208","protein_coding","chr13:85912044-85929007:-","gi|564316191|ref|XP_006221623.1|",4558,0,"PREDICTED: flocculation protein FLO11-like isoform X1 [Rattus norvegicus]","gi|672027392|ref|XM_006221562.2|",3303,0,"PREDICTED: Rattus norvegicus pyrin domain-containing protein 3-like (LOC102556096), transcript variant X2, mRNA","Q3V3Q4",430,{"v":1E-135,"d":"1.00E-135"},"Pyrin domain-containing protein 3",".",".",".",".","pfam02760","HIN","HIN-200/IF120x domain. This domain has no know function. It is found in one or two copies per protein, and is found associated with the PAAD/DAPIN domain pfam02758.",".",".",".",".","."]
["ENSRNOG00000029191",709,59.65190547,152,9.778226604,6.100483031,2.608923479,{"v":8.36e-120,"d":"8.36E-120"},1.58E-118,"up","yes","ENSRNOG00000029191","protein_coding","chr2:231275640-231297278:+","gi|392339045|ref|XP_003753713.1|",3074,0,"PREDICTED: guanylate-binding protein 4 isoform X1 [Rattus norvegicus]","gi|672016381|ref|XM_003753665.3|",3367,0,"PREDICTED: Rattus norvegicus similar to guanylate binding protein family, member 6 (LOC685067), transcript variant X1, mRNA","Q61107",877,0,"Guanylate-binding protein 4",".",".",".",".","pfam02263","GBP","Guanylate-binding protein, N-terminal domain. Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.","GO:0044406|adhesion of symbiont to host;",".",".","K20899","GBP1_3_4_7; guanylate-binding protein 1/3/4/7"]
["ENSRNOG00000059268",1811,152.3689715,967,62.20753372,2.449365252,1.292407926,{"v":1.52e-118,"d":"1.52E-118"},{"v":2.81e-117,"d":"2.81E-117"},"up","yes","Ppp1r10","protein_coding","chr20:2822995-2837611:-","gi|672085805|ref|XP_008770985.1|",2407,0,"PREDICTED: serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1 [Rattus norvegicus]","gi|261399865|ref|NM_022951.2|",4170,0,"Rattus norvegicus protein phosphatase 1, regulatory subunit 10 (Ppp1r10), mRNA","O55000",927,0,"Serine/threonine-protein phosphatase 1 regulatory subunit 10",".",".",".",".","pfam08711","Med26","TFIIS helical bundle-like domain. Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species {1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Mediator exists in two major forms in human cells: a smaller form that interacts strongly with pol II and activates transcription, and a large form that does not interact strongly with pol II and does not directly activate transcription. Notably, the 'small' and 'large' Mediator complexes differ in their subunit composition: the Med26 subunit preferentially associates with the small, active complex, whereas cdk8, cyclin C, Med12 and Med13 associate with the large Mediator complex. This family includesthe C terminal region of a number of eukaryotic hypothetical proteins which are homologous to the Saccharomyces cerevisiae protein IWS1. IWS1 is known to be an Pol II transcription elongation factor and interacts with Spt6 and Spt5.","GO:0010667|negative regulation of cardiac muscle cell apoptotic process;GO:0032206|positive regulation of telomere maintenance;GO:0043086|negative regulation of catalytic activity;GO:1904290|negative regulation of mitotic DNA damage checkpoint;","GO:0000781|chromosome, telomeric region;GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0016604|nuclear body;GO:0072357|PTW/PP1 phosphatase complex;","GO:0003677|DNA binding;GO:0003723|RNA binding;GO:0004864|protein phosphatase inhibitor activity;GO:0008157|protein phosphatase 1 binding;GO:0046872|metal ion binding;","K17552","PPP1R10; protein phosphatase 1 regulatory subunit 10"]
["ENSRNOG00000004763",685,57.63265902,143,9.19925266,6.264928375,2.647298016,1.22E-117,{"v":2.22e-116,"d":"2.22E-116"},"up","yes","Sirpa","protein_coding","chr3:116819726-116858098:+","gi|29427383|sp|P97710.1|SHPS1_RAT",2366,0,"RecName: Full=Tyrosine-protein phosphatase non-receptor type substrate 1; Short=SHP substrate 1; Short=SHPS-1; AltName: Full=Brain Ig-like molecule with tyrosine-based activation motifs; Short=Bit; AltName: Full=CD172 antigen-like family member A; AltName: Full=Inhibitory receptor SHPS-1; AltName: Full=Macrophage fusion receptor; AltName: Full=Macrophage membrane protein MFP150; AltName: Full=Signal-regulatory protein alpha-1; Short=Sirp-alpha-1; AltName: CD_antigen=CD172a; Flags: Precursor","gi|672046774|ref|XM_006234951.2|",3825,0,"PREDICTED: Rattus norvegicus signal-regulatory protein alpha (Sirpa), transcript variant X1, mRNA","P97710",915,0,"Tyrosine-protein phosphatase non-receptor type substrate 1",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0001933|negative regulation of protein phosphorylation;GO:0002244|hematopoietic progenitor cell differentiation;GO:0006910|phagocytosis, recognition;GO:0006911|phagocytosis, engulfment;GO:0007010|cytoskeleton organization;GO:0007015|actin filament organization;GO:0007160|cell-matrix adhesion;GO:0010468|regulation of gene expression;GO:0016477|cell migration;GO:0032649|regulation of interferon-gamma production;GO:0032651|regulation of interleukin-1 beta production;GO:0032675|regulation of interleukin-6 production;GO:0032680|regulation of tumor necrosis factor production;GO:0032688|negative regulation of interferon-beta production;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0034113|heterotypic cell-cell adhesion;GO:0035696|monocyte extravasation;GO:0045019|negative regulation of nitric oxide biosynthetic process;GO:0045428|regulation of nitric oxide biosynthetic process;GO:0046329|negative regulation of JNK cascade;GO:0050728|negative regulation of inflammatory response;GO:0050765|negative regulation of phagocytosis;GO:0050766|positive regulation of phagocytosis;GO:0050790|regulation of catalytic activity;GO:0050870|positive regulation of T cell activation;GO:0070301|cellular response to hydrogen peroxide;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0071222|cellular response to lipopolysaccharide;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071349|cellular response to interleukin-12;GO:0071641|negative regulation of macrophage inflammatory protein 1 alpha production;GO:0071650|negative regulation of chemokine (C-C motif) ligand 5 production;GO:0097530|granulocyte migration;GO:1900016|negative regulation of cytokine production involved in inflammatory response;GO:1903720|negative regulation of I-kappaB phosphorylation;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;","GO:0005515|protein binding;GO:0017124|SH3 domain binding;GO:0019903|protein phosphatase binding;GO:0030695|GTPase regulator activity;GO:0045309|protein phosphorylated amino acid binding;GO:0086080|protein binding involved in heterotypic cell-cell adhesion;GO:0098632|cell-cell adhesion mediator activity;GO:1990405|protein antigen binding;GO:1990782|protein tyrosine kinase binding;","K06551","SIRPA_B1_G, CD172; signal-regulatory protein alpha/beta1/gamma"]
["ENSRNOG00000022298",426,35.84162444,13,0.836295696,42.85759761,5.421479077,2.56E-117,{"v":4.62e-116,"d":"4.62E-116"},"up","yes","Cxcl11","protein_coding","chr14:15689424-15692271:+","gi|33636734|ref|NP_891997.1|",527,{"v":4e-63,"d":"4.00E-63"},"C-X-C motif chemokine 11 precursor [Rattus norvegicus]","gi|197246580|gb|BC168725.1|",1123,0,"Rattus norvegicus chemokine (C-X-C motif) ligand 11, mRNA (cDNA clone MGC:188799 IMAGE:6919932), complete cds","Q9JHH5",137,{"v":8e-38,"d":"8.00E-38"},"C-X-C motif chemokine 11",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0010818|T cell chemotaxis;GO:0030593|neutrophil chemotaxis;GO:0031640|killing of cells of other organism;GO:0042127|regulation of cell proliferation;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098|chemokine-mediated signaling pathway;GO:0071222|cellular response to lipopolysaccharide;","GO:0005615|extracellular space;GO:0016021|integral component of membrane;","GO:0008009|chemokine activity;GO:0008201|heparin binding;GO:0042379|chemokine receptor binding;GO:0045236|CXCR chemokine receptor binding;GO:0048248|CXCR3 chemokine receptor binding;","K12672","CXCL11, I-TAC; C-X-C motif chemokine 11"]
["ENSRNOG00000032240",507,42.6565812,53,3.409513224,12.5110473,3.645130657,{"v":7.89e-117,"d":"7.89E-117"},{"v":1.42e-115,"d":"1.42E-115"},"up","yes","Gbp5","protein_coding","chr2:231237748-231257061:+","gi|166091462|ref|NP_001102039.2|",2598,0,"guanylate-binding protein 5 [Rattus norvegicus]","gi|214010143|ref|NM_001108569.3|",2759,0,"Rattus norvegicus guanylate binding protein 5 (Gbp5), mRNA","Q8CFB4",828,0,"Guanylate-binding protein 5",".",".",".",".","pfam02263","GBP","Guanylate-binding protein, N-terminal domain. Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.","GO:0009617|response to bacterium;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032741|positive regulation of interleukin-18 production;GO:0034067|protein localization to Golgi apparatus;GO:0045089|positive regulation of innate immune response;GO:0051289|protein homotetramerization;GO:0071346|cellular response to interferon-gamma;GO:1900017|positive regulation of cytokine production involved in inflammatory response;GO:1900227|positive regulation of NLRP3 inflammasome complex assembly;","GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0031410|cytoplasmic vesicle;GO:0048471|perinuclear region of cytoplasm;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;","K20898","GBP5; guanylate-binding protein 5"]
["ENSRNOG00000014956",719,60.49325816,171,11.00050493,5.49913468,2.45920462,{"v":8.45e-114,"d":"8.45E-114"},{"v":1.5E-112,"d":"1.50E-112"},"up","yes","Slc11a1","protein_coding","chr9:75957316-75968101:+","gi|564369044|ref|XP_006245281.1|",2746,0,"PREDICTED: natural resistance-associated macrophage protein 1 isoform X1 [Rattus norvegicus]","gi|672065608|ref|XM_006245219.2|",1886,0,"PREDICTED: Rattus norvegicus solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 (Slc11a1), transcript variant X1, mRNA","P41251",995,0,"Natural resistance-associated macrophage protein 1","mlr2501",266,{"v":2E-79,"d":"2.00E-79"},"COG1914","pfam01566","Nramp","Natural resistance-associated macrophage protein. The natural resistance-associated macrophage protein (NRAMP) family consists of Nramp1, Nramp2, and yeast proteins Smf1 and Smf2. The NRAMP family is a novel family of functional related proteins defined by a conserved hydrophobic core of ten transmembrane domains. This family of membrane proteins are divalent cation transporters. Nramp1 is an integral membrane protein expressed exclusively in cells of the immune system and is recruited to the membrane of a phagosome upon phagocytosis. By controlling divalent cation concentrations Nramp1 may regulate the interphagosomal replication of bacteria. Mutations in Nramp1 may genetically predispose an individual to susceptibility to diseases including leprosy and tuberculosis conversely this might however provide protection form rheumatoid arthritis. Nramp2 is a multiple divalent cation transporter for Fe2+, Mn2+ and Zn2+ amongst others it is expressed at high levels in the intestine; and is major transferrin-independent iron uptake system in mammals. The yeast proteins Smf1 and Smf2 may also transport divalent cations.","GO:0000165|MAPK cascade;GO:0001818|negative regulation of cytokine production;GO:0001819|positive regulation of cytokine production;GO:0002309|T cell proliferation involved in immune response;GO:0002606|positive regulation of dendritic cell antigen processing and presentation;GO:0002827|positive regulation of T-helper 1 type immune response;GO:0006826|iron ion transport;GO:0006828|manganese ion transport;GO:0006876|cellular cadmium ion homeostasis;GO:0006879|cellular iron ion homeostasis;GO:0006909|phagocytosis;GO:0006954|inflammatory response;GO:0007035|vacuolar acidification;GO:0008150|biological_process;GO:0009617|response to bacterium;GO:0010628|positive regulation of gene expression;GO:0015707|nitrite transport;GO:0030001|metal ion transport;GO:0032147|activation of protein kinase activity;GO:0032496|response to lipopolysaccharide;GO:0032729|positive regulation of interferon-gamma production;GO:0034341|response to interferon-gamma;GO:0034755|iron ion transmembrane transport;GO:0042060|wound healing;GO:0042116|macrophage activation;GO:0042742|defense response to bacterium;GO:0042832|defense response to protozoan;GO:0045342|MHC class II biosynthetic process;GO:0045730|respiratory burst;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048002|antigen processing and presentation of peptide antigen;GO:0048255|mRNA stabilization;GO:0050766|positive regulation of phagocytosis;GO:0050829|defense response to Gram-negative bacterium;GO:0055072|iron ion homeostasis;GO:0060586|multicellular organismal iron ion homeostasis;GO:0070574|cadmium ion transmembrane transport;GO:0070839|divalent metal ion export;GO:0071421|manganese ion transmembrane transport;GO:1902023|L-arginine transport;","GO:0005575|cellular_component;GO:0005764|lysosome;GO:0005770|late endosome;GO:0005886|plasma membrane;GO:0010008|endosome membrane;GO:0016021|integral component of membrane;GO:0030670|phagocytic vesicle membrane;GO:0070821|tertiary granule membrane;","GO:0003674|molecular_function;GO:0005381|iron ion transmembrane transporter activity;GO:0005384|manganese ion transmembrane transporter activity;GO:0015086|cadmium ion transmembrane transporter activity;GO:0042803|protein homodimerization activity;GO:0046873|metal ion transmembrane transporter activity;GO:0046915|transition metal ion transmembrane transporter activity;GO:0051139|metal ion:proton antiporter activity;","K12347","SLC11A1, NRAMP1; natural resistance-associated macrophage protein 1"]
["ENSRNOG00000059097",471,39.62771153,42,2.701878404,14.66672648,3.874475002,{"v":2.6e-113,"d":"2.60E-113"},{"v":4.61e-112,"d":"4.61E-112"},"up","yes","AABR07025140.1","protein_coding","chr16:28076999-28179526:-","gi|564324417|ref|XP_006227112.1|",8538,0,"PREDICTED: probable ATP-dependent RNA helicase DDX60 isoform X3 [Rattus norvegicus]","gi|672033286|ref|XM_006227050.2|",5280,0,"PREDICTED: Rattus norvegicus DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 (Ddx60), transcript variant X3, mRNA","Q8IY21",2548,0,"Probable ATP-dependent RNA helicase DDX60","SPAC694.02",457,{"v":2E-131,"d":"2.00E-131"},"COG4581","pfam00270","DEAD","DEAD/DEAH box helicase. Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolizm, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.",".",".",".",".","."]
["ENSRNOG00000001224",674,56.70717107,146,9.392243975,6.037659501,2.593989397,{"v":2.78e-113,"d":"2.78E-113"},{"v":4.91e-112,"d":"4.91E-112"},"up","yes","Itgb2","protein_coding","chr20:11061430-11097600:-","gi|163937849|ref|NP_001032869.2|",3677,0,"integrin beta-2 precursor [Rattus norvegicus]","gi|163937848|ref|NM_001037780.2|",3151,0,"Rattus norvegicus integrin, beta 2 (Itgb2), mRNA","P11835",1291,0,"Integrin beta-2",".",".",".",".","pfam00362","Integrin_beta","Integrin, beta chain. Integrins have been found in animals and their homologues have also been found in cyanobacteria, probably due to horizontal gene transfer. The sequences repeats have been trimmed due to an overlap with EGF.","GO:0002523|leukocyte migration involved in inflammatory response;GO:0006898|receptor-mediated endocytosis;GO:0006911|phagocytosis, engulfment;GO:0007155|cell adhesion;GO:0007159|leukocyte cell-cell adhesion;GO:0007160|cell-matrix adhesion;GO:0007229|integrin-mediated signaling pathway;GO:0007568|aging;GO:0016477|cell migration;GO:0030101|natural killer cell activation;GO:0030593|neutrophil chemotaxis;GO:0031623|receptor internalization;GO:0032930|positive regulation of superoxide anion generation;GO:0033627|cell adhesion mediated by integrin;GO:0034113|heterotypic cell-cell adhesion;GO:0035987|endodermal cell differentiation;GO:0043113|receptor clustering;GO:0043315|positive regulation of neutrophil degranulation;GO:0043542|endothelial cell migration;GO:0045123|cellular extravasation;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0045766|positive regulation of angiogenesis;GO:0050730|regulation of peptidyl-tyrosine phosphorylation;GO:0050766|positive regulation of phagocytosis;GO:0050798|activated T cell proliferation;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0071404|cellular response to low-density lipoprotein particle stimulus;GO:0097242|amyloid-beta clearance;GO:0098609|cell-cell adhesion;GO:1904996|positive regulation of leukocyte adhesion to vascular endothelial cell;GO:1990266|neutrophil migration;","GO:0005886|plasma membrane;GO:0005925|focal adhesion;GO:0008305|integrin complex;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0034687|integrin alphaL-beta2 complex;GO:0034688|integrin alphaM-beta2 complex;GO:0043235|receptor complex;GO:0044853|plasma membrane raft;GO:0045121|membrane raft;","GO:0001540|amyloid-beta binding;GO:0001851|complement component C3b binding;GO:0005178|integrin binding;GO:0019901|protein kinase binding;GO:0030369|ICAM-3 receptor activity;GO:0031072|heat shock protein binding;GO:0038024|cargo receptor activity;GO:0044877|protein-containing complex binding;GO:0046872|metal ion binding;GO:0050839|cell adhesion molecule binding;","K06464","ITGB2, CD18; integrin beta 2"]
["ENSRNOG00000010018",634,53.34176032,126,8.105635211,6.580824196,2.718268281,{"v":4.2e-112,"d":"4.20E-112"},{"v":7.29e-111,"d":"7.29E-111"},"up","yes","Clec4a3","protein_coding","chr4:156214718-156224817:+","gi|564348867|ref|XP_006237383.1|",1076,{"v":3e-143,"d":"3.00E-143"},"PREDICTED: C-type lectin domain family 4, member A3 isoform X1 [Rattus norvegicus]","gi|672050888|ref|XM_006237321.2|",1264,0,"PREDICTED: Rattus norvegicus C-type lectin domain family 4, member A3 (Clec4a3), transcript variant X1, mRNA","Q9QZ15",235,{"v":5e-73,"d":"5.00E-73"},"C-type lectin domain family 4 member A",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0001818|negative regulation of cytokine production;GO:0002470|plasmacytoid dendritic cell antigen processing and presentation;GO:0032720|negative regulation of tumor necrosis factor production;GO:0036037|CD8-positive, alpha-beta T cell activation;GO:0042590|antigen processing and presentation of exogenous peptide antigen via MHC class I;","GO:0016021|integral component of membrane;","GO:0005509|calcium ion binding;GO:0005537|mannose binding;GO:0030246|carbohydrate binding;","K10057","CLEC4A, CD367; C-type lectin domain family 4 member A"]
["ENSRNOG00000006384",806,67.81302653,230,14.79600078,4.583199712,2.196355152,{"v":1.67e-111,"d":"1.67E-111"},{"v":2.87e-110,"d":"2.87E-110"},"up","yes","Ddx58","protein_coding","chr5:55321235-55370819:-","gi|153945886|ref|NP_766277.3|",4148,0,"probable ATP-dependent RNA helicase DDX58 [Mus musculus]","gi|153945885|ref|NM_172689.3|",2198,0,"Mus musculus DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (Ddx58), mRNA","Q6Q899",1602,0,"Probable ATP-dependent RNA helicase DDX58","PAB0190_1",131,{"v":6e-31,"d":"6.00E-31"},"COG1111","pfam11648","RIG-I_C-RD","C-terminal domain of RIG-I. This family of proteins represents the regulatory domain RD of RIG-I, a protein which initiates a signalling cascade that provides essential antiviral protection for the host. The RD domain binds viral RNA, activating the RIG-I ATPase by RNA-dependant dimerization. The structure of RD contains a zinc-binding domain and is thought to confer ligand specificity.","GO:0002230|positive regulation of defense response to virus by host;GO:0002735|positive regulation of myeloid dendritic cell cytokine production;GO:0009597|detection of virus;GO:0009615|response to virus;GO:0010628|positive regulation of gene expression;GO:0030334|regulation of cell migration;GO:0032725|positive regulation of granulocyte macrophage colony-stimulating factor production;GO:0032727|positive regulation of interferon-alpha production;GO:0032728|positive regulation of interferon-beta production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0039529|RIG-I signaling pathway;GO:0043330|response to exogenous dsRNA;GO:0045087|innate immune response;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051607|defense response to virus;GO:0060760|positive regulation of response to cytokine stimulus;GO:0071360|cellular response to exogenous dsRNA;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005923|bicellular tight junction;GO:0015629|actin cytoskeleton;GO:0032587|ruffle membrane;GO:1990904|ribonucleoprotein complex;","GO:0003690|double-stranded DNA binding;GO:0003725|double-stranded RNA binding;GO:0003727|single-stranded RNA binding;GO:0005524|ATP binding;GO:0008270|zinc ion binding;GO:0016787|hydrolase activity;GO:0031625|ubiquitin protein ligase binding;GO:0042802|identical protein binding;","K12646","DDX58, RIG-I; ATP-dependent RNA helicase DDX58 [EC:3.6.4.13]"]
["ENSRNOG00000031081",1465,123.2581686,714,45.93193286,2.683496228,1.42411386,{"v":2.32e-111,"d":"2.32E-111"},{"v":3.96e-110,"d":"3.96E-110"},"up","yes","Stat2","protein_coding","chr7:702495-718967:+","gi|58865380|ref|NP_001011905.1|",3913,0,"signal transducer and activator of transcription 2 [Rattus norvegicus]","gi|672057475|ref|XM_006240747.2|",1977,0,"PREDICTED: Rattus norvegicus signal transducer and activator of transcription 2 (Stat2), transcript variant X1, mRNA","Q9WVL2",1154,0,"Signal transducer and activator of transcription 2",".",".",".",".","pfam02864","STAT_bind","STAT protein, DNA binding domain. STAT proteins (Signal Transducers and Activators of Transcription) are a family of transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors. This family represents the DNA binding domain of STAT, which has an ig-like fold. STAT proteins also include an SH2 domain pfam00017.","GO:0001932|regulation of protein phosphorylation;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006952|defense response;GO:0007259|JAK-STAT cascade;GO:0008150|biological_process;GO:0019221|cytokine-mediated signaling pathway;GO:0042127|regulation of cell proliferation;GO:0043434|response to peptide hormone;GO:0051607|defense response to virus;GO:0060337|type I interferon signaling pathway;GO:0060339|negative regulation of type I interferon-mediated signaling pathway;GO:0090140|regulation of mitochondrial fission;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0042802|identical protein binding;GO:0044389|ubiquitin-like protein ligase binding;","K11221","STAT2; signal transducer and activator of transcription 2"]
["ENSRNOG00000001469",1661,139.7486812,877,56.41779429,2.477031989,1.3086125,{"v":5.67e-111,"d":"5.67E-111"},{"v":9.59e-110,"d":"9.59E-110"},"up","yes","Eln","protein_coding","chr12:21968544-22011928:+","gi|674078310|ref|XP_008846618.1|",306,{"v":1E-26,"d":"1.00E-26"},"PREDICTED: elastin [Nannospalax galili]","gi|55742708|ref|NM_012722.1|",3581,0,"Rattus norvegicus elastin (Eln), mRNA",".",".",".",".",".",".",".",".","pfam02711","Pap_E4","E4 protein. This is is a family of Papillomavirus proteins, E4, coded for by ORF4. A splice variant, E1--E4, exists but neither the function of E4 or E1--E4 is known.","GO:0001974|blood vessel remodeling;GO:0003151|outflow tract morphogenesis;GO:0007519|skeletal muscle tissue development;GO:0007568|aging;GO:0009410|response to xenobiotic stimulus;GO:0030198|extracellular matrix organization;GO:0030833|regulation of actin filament polymerization;GO:0035904|aorta development;GO:0043149|stress fiber assembly;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0048251|elastic fiber assembly;GO:0055093|response to hyperoxia;GO:0071280|cellular response to copper ion;GO:0071298|cellular response to L-ascorbic acid;GO:0071300|cellular response to retinoic acid;GO:0071407|cellular response to organic cyclic compound;GO:0071456|cellular response to hypoxia;GO:0071549|cellular response to dexamethasone stimulus;GO:0071560|cellular response to transforming growth factor beta stimulus;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0031012|extracellular matrix;GO:0062023|collagen-containing extracellular matrix;GO:0071953|elastic fiber;","GO:0005201|extracellular matrix structural constituent;GO:0030023|extracellular matrix constituent conferring elasticity;GO:0050840|extracellular matrix binding;","K14211","ELN; elastin"]
["ENSRNOG00000020845",1145,96.3348826,469,30.17097551,3.192965457,1.674896945,2.21E-110,{"v":3.72e-109,"d":"3.72E-109"},"up","yes","Tyrobp","protein_coding","chr1:85672994-85676848:+","gi|47058976|ref|NP_997690.1|",594,{"v":7e-76,"d":"7.00E-76"},"TYRO protein tyrosine kinase-binding protein precursor [Rattus norvegicus]","gi|298889183|emb|FQ211365.1|",529,0,"Rattus norvegicus TL0ABA12YD08 mRNA sequence","Q6X9T7",233,{"v":2e-77,"d":"2.00E-77"},"TYRO protein tyrosine kinase-binding protein",".",".",".",".","pfam07213","DAP10","DAP10 membrane protein. This family consists of several mammalian DAP10 membrane proteins. In activated mouse natural killer (NK) cells, the NKG2D receptor associates with two intracellular adaptors, DAP10 and DAP12, which trigger phosphatidyl inositol 3 kinase (PI3K) and Syk family protein tyrosine kinases, respectively. It has been suggested that the DAP10-PI3K pathway is sufficient to initiate NKG2D-mediated killing of target cells.","GO:0002222|stimulatory killer cell immunoglobulin-like receptor signaling pathway;GO:0002223|stimulatory C-type lectin receptor signaling pathway;GO:0002274|myeloid leukocyte activation;GO:0002281|macrophage activation involved in immune response;GO:0002282|microglial cell activation involved in immune response;GO:0002283|neutrophil activation involved in immune response;GO:0007229|integrin-mediated signaling pathway;GO:0010628|positive regulation of gene expression;GO:0030036|actin cytoskeleton organization;GO:0030316|osteoclast differentiation;GO:0030889|negative regulation of B cell proliferation;GO:0030900|forebrain development;GO:0032693|negative regulation of interleukin-10 production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032755|positive regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032816|positive regulation of natural killer cell activation;GO:0032911|negative regulation of transforming growth factor beta1 production;GO:0032930|positive regulation of superoxide anion generation;GO:0034241|positive regulation of macrophage fusion;GO:0043277|apoptotic cell clearance;GO:0048678|response to axon injury;GO:0050821|protein stabilization;GO:0097190|apoptotic signaling pathway;GO:0110090|positive regulation of hippocampal neuron apoptotic process;GO:1900272|negative regulation of long-term synaptic potentiation;GO:1901216|positive regulation of neuron death;GO:1902685|positive regulation of receptor localization to synapse;GO:1904151|positive regulation of microglial cell mediated cytotoxicity;GO:2000010|positive regulation of protein localization to cell surface;GO:2001204|regulation of osteoclast development;GO:2001206|positive regulation of osteoclast development;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;","GO:0005102|signaling receptor binding;GO:0005515|protein binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0046872|metal ion binding;","K07992","TYROBP, DAP12; TYRO protein tyrosine kinase binding protein"]
["ENSRNOG00000010725",735,61.83942246,190,12.22278326,5.059356872,2.338954006,8.79E-110,{"v":1.46e-108,"d":"1.46E-108"},"up","yes","Cpa1","protein_coding","chr4:59257417-59263544:+","gi|333033815|ref|NP_058694.2|",2260,0,"carboxypeptidase A1 preproprotein [Rattus norvegicus]","gi|333033814|ref|NM_016998.3|",1633,0,"Rattus norvegicus carboxypeptidase A1 (Cpa1), mRNA","P00731",875,0,"Carboxypeptidase A1","YHR132c",176,{"v":4e-48,"d":"4.00E-48"},"COG2866","pfam00246","Peptidase_M14","Zinc carboxypeptidase.","GO:0006508|proteolysis;GO:0006691|leukotriene metabolic process;GO:0051603|proteolysis involved in cellular protein catabolic process;","GO:0005615|extracellular space;","GO:0004181|metallocarboxypeptidase activity;GO:0008238|exopeptidase activity;GO:0008270|zinc ion binding;","K08779","CPA1; carboxypeptidase A1 [EC:3.4.17.1]"]
["ENSRNOG00000000655",734,61.75528719,190,12.22278326,5.052473393,2.336989819,1.58E-109,{"v":2.62e-108,"d":"2.62E-108"},"up","yes","Ptprc","protein_coding","chr13:49596193-49708692:-","gi|56559|emb|CAA68272.1|",5958,0,"unnamed protein product [Rattus norvegicus]","gi|205146|gb|M18349.1|RATLCAG1",8442,0,"Rat leukocyte common antigen (L-CA) gene, exons 1 through 5","P04157",2296,0,"Receptor-type tyrosine-protein phosphatase C","SPAC19D5.01",135,{"v":8e-31,"d":"8.00E-31"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0001779|natural killer cell differentiation;GO:0001915|negative regulation of T cell mediated cytotoxicity;GO:0001916|positive regulation of T cell mediated cytotoxicity;GO:0001960|negative regulation of cytokine-mediated signaling pathway;GO:0002244|hematopoietic progenitor cell differentiation;GO:0002639|positive regulation of immunoglobulin production;GO:0002711|positive regulation of T cell mediated immunity;GO:0002923|regulation of humoral immune response mediated by circulating immunoglobulin;GO:0002925|positive regulation of humoral immune response mediated by circulating immunoglobulin;GO:0006469|negative regulation of protein kinase activity;GO:0006470|protein dephosphorylation;GO:0006933|negative regulation of cell adhesion involved in substrate-bound cell migration;GO:0007159|leukocyte cell-cell adhesion;GO:0010332|response to gamma radiation;GO:0010468|regulation of gene expression;GO:0016311|dephosphorylation;GO:0030183|B cell differentiation;GO:0030217|T cell differentiation;GO:0030890|positive regulation of B cell proliferation;GO:0031668|cellular response to extracellular stimulus;GO:0031953|negative regulation of protein autophosphorylation;GO:0032677|regulation of interleukin-8 production;GO:0032703|negative regulation of interleukin-2 production;GO:0032743|positive regulation of interleukin-2 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0034113|heterotypic cell-cell adhesion;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0035584|calcium-mediated signaling using intracellular calcium source;GO:0042098|T cell proliferation;GO:0042100|B cell proliferation;GO:0042102|positive regulation of T cell proliferation;GO:0043406|positive regulation of MAP kinase activity;GO:0043410|positive regulation of MAPK cascade;GO:0044770|cell cycle phase transition;GO:0044855|plasma membrane raft distribution;GO:0045059|positive thymic T cell selection;GO:0045060|negative thymic T cell selection;GO:0045582|positive regulation of T cell differentiation;GO:0045588|positive regulation of gamma-delta T cell differentiation;GO:0046425|regulation of JAK-STAT cascade;GO:0046641|positive regulation of alpha-beta T cell proliferation;GO:0048304|positive regulation of isotype switching to IgG isotypes;GO:0048539|bone marrow development;GO:0048864|stem cell development;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050732|negative regulation of peptidyl-tyrosine phosphorylation;GO:0050764|regulation of phagocytosis;GO:0050852|T cell receptor signaling pathway;GO:0050853|B cell receptor signaling pathway;GO:0050857|positive regulation of antigen receptor-mediated signaling pathway;GO:0051209|release of sequestered calcium ion into cytosol;GO:0051607|defense response to virus;GO:0051726|regulation of cell cycle;GO:0061097|regulation of protein tyrosine kinase activity;GO:0061099|negative regulation of protein tyrosine kinase activity;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:1903615|positive regulation of protein tyrosine phosphatase activity;GO:1905451|positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis;GO:2000473|positive regulation of hematopoietic stem cell migration;GO:2000648|positive regulation of stem cell proliferation;GO:2001236|regulation of extrinsic apoptotic signaling pathway;GO:2001238|positive regulation of extrinsic apoptotic signaling pathway;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005925|focal adhesion;GO:0009897|external side of plasma membrane;GO:0009898|cytoplasmic side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0032059|bleb;GO:0045121|membrane raft;GO:0071944|cell periphery;GO:0098857|membrane microdomain;","GO:0004725|protein tyrosine phosphatase activity;GO:0005001|transmembrane receptor protein tyrosine phosphatase activity;GO:0005102|signaling receptor binding;GO:0005515|protein binding;GO:0008201|heparin binding;GO:0019887|protein kinase regulator activity;GO:0019901|protein kinase binding;GO:0030506|ankyrin binding;GO:0030507|spectrin binding;GO:0043395|heparan sulfate proteoglycan binding;","K06478","PTPRC, CD45; receptor-type tyrosine-protein phosphatase C [EC:3.1.3.48]"]
["ENSRNOG00000020300",947,79.67609941,331,21.29337504,3.741825768,1.903742383,{"v":5.61e-109,"d":"5.61E-109"},{"v":9.25e-108,"d":"9.25E-108"},"up","yes","Lsp1","protein_coding","chr1:197614687-197648416:+","gi|162287322|ref|NP_001020591.1|",908,{"v":2e-111,"d":"2.00E-111"},"lymphocyte-specific protein 1 [Rattus norvegicus]","gi|33354295|gb|AC098563.6|",1479,0,"Rattus norvegicus 1 BAC CH230-123A15 (Children's Hospital Oakland Research Institute) complete sequence","P19973",295,{"v":2E-90,"d":"2.00E-90"},"Lymphocyte-specific protein 1",".",".",".",".","pfam02029","Caldesmon","Caldesmon.","GO:0006935|chemotaxis;GO:0006952|defense response;GO:0007165|signal transduction;GO:0098761|cellular response to interleukin-7;",".","GO:0003779|actin binding;","K14957","LSP1; lymphocyte-specific protein 1"]
["ENSRNOG00000001005",474,39.88011734,51,3.280852347,12.15541363,3.603527082,{"v":1.93e-108,"d":"1.93E-108"},{"v":3.15e-107,"d":"3.15E-107"},"up","yes","Fcer2","protein_coding","chr12:1742815-1754476:-","gi|76781460|ref|NP_001029096.1|",1572,0,"low affinity immunoglobulin epsilon Fc receptor isoform a [Rattus norvegicus]","gi|76781459|ref|NM_001033924.1|",1995,0,"Rattus norvegicus Fc fragment of IgE receptor II (Fcer2), transcript variant 1, mRNA","P20693",555,0,"Low affinity immunoglobulin epsilon Fc receptor",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0002925|positive regulation of humoral immune response mediated by circulating immunoglobulin;GO:0051000|positive regulation of nitric-oxide synthase activity;GO:0051712|positive regulation of killing of cells of other organism;GO:0051770|positive regulation of nitric-oxide synthase biosynthetic process;","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0030246|carbohydrate binding;","K06468","FCER2, CD23; low affinity immunoglobulin epsilon Fc receptor"]
["ENSRNOG00000016945",664,55.86581838,158,10.16420923,5.496327073,2.458467858,{"v":3.3e-105,"d":"3.30E-105"},{"v":5.33e-104,"d":"5.33E-104"},"up","yes","Pla2g2a","protein_coding","chr5:151076442-151079014:+","gi|291621686|ref|NP_113786.3|",770,{"v":2E-100,"d":"2.00E-100"},"phospholipase A2, membrane associated precursor [Rattus norvegicus]","gi|672054379|ref|XM_006239146.2|",859,0,"PREDICTED: Rattus norvegicus phospholipase A2, group IIA (platelets, synovial fluid) (Pla2g2a), transcript variant X1, mRNA","P14423",301,{"v":8e-102,"d":"8.00E-102"},"Phospholipase A2, membrane associated",".",".",".",".","pfam00068","Phospholip_A2_1","Phospholipase A2. Phospholipase A2 releases fatty acids from the second carbon group of glycerol. Perhaps the best known members are secreted snake venoms, but also found in secreted pancreatic and membrane-associated forms. Structure is all-alpha, with two core disulfide-linked helices and a calcium-binding loop. This alignment represents the major family of PLA2s. A second minor family, defined by the honeybee venom PLA2 PDB:1POC and related sequences from Gila monsters (Heloderma), is not recognized. This minor family conserves the core helix pair but is substantially different elsewhere. The PROSITE pattern PA2_HIS, specific to the first core helix, recognizes both families.","GO:0006644|phospholipid metabolic process;GO:0006954|inflammatory response;GO:0016042|lipid catabolic process;GO:0019835|cytolysis;GO:0036335|intestinal stem cell homeostasis;GO:0046337|phosphatidylethanolamine metabolic process;GO:0046470|phosphatidylcholine metabolic process;GO:0046473|phosphatidic acid metabolic process;GO:0050482|arachidonic acid secretion;GO:0050830|defense response to Gram-positive bacterium;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:1902563|regulation of neutrophil activation;","GO:0005615|extracellular space;GO:0005741|mitochondrial outer membrane;GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0030141|secretory granule;GO:0048471|perinuclear region of cytoplasm;","GO:0004623|phospholipase A2 activity;GO:0005509|calcium ion binding;GO:0005543|phospholipid binding;GO:0047498|calcium-dependent phospholipase A2 activity;","K01047","PLA2G, SPLA2; secretory phospholipase A2 [EC:3.1.1.4]"]
["ENSRNOG00000005809",838,70.50535513,274,17.62654006,3.999954323,1.999983525,{"v":4.78e-103,"d":"4.78E-103"},{"v":7.48e-102,"d":"7.48E-102"},"up","yes","Arhgdib","protein_coding","chr4:169822952-169841658:-","gi|57527565|ref|NP_001009600.1|",1048,{"v":3e-139,"d":"3.00E-139"},"rho GDP-dissociation inhibitor 2 [Rattus norvegicus]","gi|672051435|ref|XM_006237562.2|",1276,0,"PREDICTED: Rattus norvegicus Rho, GDP dissociation inhibitor (GDI) beta (Arhgdib), transcript variant X2, mRNA","Q61599",394,{"v":4e-135,"d":"4.00E-135"},"Rho GDP-dissociation inhibitor 2",".",".",".",".","pfam02115","Rho_GDI","RHO protein GDP dissociation inhibitor.","GO:0007266|Rho protein signal transduction;GO:0035023|regulation of Rho protein signal transduction;GO:0050790|regulation of catalytic activity;GO:0071461|cellular response to redox state;GO:1901164|negative regulation of trophoblast cell migration;GO:2000249|regulation of actin cytoskeleton reorganization;","GO:0005829|cytosol;GO:0016020|membrane;","GO:0003924|GTPase activity;GO:0005094|Rho GDP-dissociation inhibitor activity;GO:0031267|small GTPase binding;","K12462","ARHGDI, RHOGDI; Rho GDP-dissociation inhibitor"]
["ENSRNOG00000027350",1103,92.80120132,468,30.10664507,3.082415895,1.624061531,{"v":6.61e-102,"d":"6.61E-102"},1.02E-100,"up","yes","Tns4","protein_coding","chr10:84021966-84041346:-","gi|149054153|gb|EDM05970.1|",3378,0,"tensin 4 [Rattus norvegicus]","gi|67846031|ref|NM_001024881.1|",2467,0,"Rattus norvegicus tensin 4 (Tns4), mRNA","Q4V8I3",1304,0,"Tensin-4",".",".",".",".","pfam08416","PTB","Phosphotyrosine-binding domain. The phosphotyrosine-binding domain (PTB, also phosphotyrosine-interaction or PI domain) in the protein tensin tends to be found at the C-terminus. Tensin is a multi-domain protein that binds to actin filaments and functions as a focal-adhesion molecule (focal adhesions are regions of plasma membrane through which cells attach to the extracellular matrix). Human tensin has actin-binding sites, an SH2 (pfam00017) domain and a region similar to the tumor suppressor PTEN. The PTB domain interacts with the cytoplasmic tails of beta integrin by binding to an NPXY motif.","GO:0006915|apoptotic process;GO:0008104|protein localization;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005925|focal adhesion;","GO:0003779|actin binding;","K18080","TNS; tensin"]
["ENSRNOG00000047307",392,32.98102531,26,1.672591393,19.71851909,4.301479301,{"v":1.79e-100,"d":"1.79E-100"},2.73E-99,"up","yes","Cntfr","protein_coding","chr5:56823965-56841392:-","gi|149045684|gb|EDL98684.1|",1676,0,"ciliary neurotrophic factor receptor, isoform CRA_b [Rattus norvegicus]","gi|51556266|ref|NM_001003929.1|",1242,0,"Rattus norvegicus ciliary neurotrophic factor receptor (Cntfr), mRNA","Q08406",648,0,"Ciliary neurotrophic factor receptor subunit alpha",".",".",".",".","pfam00041","fn3","Fibronectin type III domain.","GO:0001967|suckling behavior;GO:0003360|brainstem development;GO:0007548|sex differentiation;GO:0008284|positive regulation of cell proliferation;GO:0019221|cytokine-mediated signaling pathway;GO:0043524|negative regulation of neuron apoptotic process;GO:0060538|skeletal muscle organ development;GO:0070120|ciliary neurotrophic factor-mediated signaling pathway;","GO:0009897|external side of plasma membrane;GO:0016324|apical plasma membrane;GO:0031225|anchored component of membrane;GO:0043235|receptor complex;GO:0070110|ciliary neurotrophic factor receptor complex;GO:0097059|CNTFR-CLCF1 complex;","GO:0004896|cytokine receptor activity;GO:0004897|ciliary neurotrophic factor receptor activity;GO:0005102|signaling receptor binding;GO:0019955|cytokine binding;","K05059","CNTFR; ciliary neurotrophic factor receptor"]
["ENSRNOG00000056947",397,33.40170165,29,1.865582707,17.90416556,4.162223377,{"v":5.4e-100,"d":"5.40E-100"},{"v":8.22e-99,"d":"8.22E-99"},"up","yes","AABR07025272.1","protein_coding","chr16:27840998-27951324:-","gi|564324417|ref|XP_006227112.1|",8478,0,"PREDICTED: probable ATP-dependent RNA helicase DDX60 isoform X3 [Rattus norvegicus]","gi|672033286|ref|XM_006227050.2|",5363,0,"PREDICTED: Rattus norvegicus DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 (Ddx60), transcript variant X3, mRNA","Q8IY21",2542,0,"Probable ATP-dependent RNA helicase DDX60","SPAC694.02",460,{"v":4e-132,"d":"4.00E-132"},"COG4581","pfam00270","DEAD","DEAD/DEAH box helicase. Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolizm, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.",".",".",".",".","."]
["ENSRNOG00000007539",427,35.92575971,46,2.959200157,12.14036152,3.601739478,{"v":7.63e-98,"d":"7.63E-98"},1.13E-96,"up","yes","Rsad2","protein_coding","chr6:43047658-43059699:-","gi|149051031|gb|EDM03204.1|",1839,0,"rCG62278 [Rattus norvegicus]","gi|20302056|ref|NM_138881.1|",2366,0,"Rattus norvegicus radical S-adenosyl methionine domain containing 2 (Rsad2), mRNA","O70600",707,0,"Radical S-adenosyl methionine domain-containing protein 2","BH2526",56.2,{"v":2e-07,"d":"2.00E-07"},"COG2896","pfam04055","Radical_SAM","Radical SAM superfamily. Radical SAM proteins catalyse diverse reactions, including unusual methylations, isomerization, sulphur insertion, ring formation, anaerobic oxidation and protein radical formation.","GO:0001503|ossification;GO:0009615|response to virus;GO:0030278|regulation of ossification;GO:0034157|positive regulation of toll-like receptor 7 signaling pathway;GO:0034165|positive regulation of toll-like receptor 9 signaling pathway;GO:0035710|CD4-positive, alpha-beta T cell activation;GO:0043367|CD4-positive, alpha-beta T cell differentiation;GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0050709|negative regulation of protein secretion;GO:0050778|positive regulation of immune response;GO:0051607|defense response to virus;GO:2000553|positive regulation of T-helper 2 cell cytokine production;","GO:0001650|fibrillar center;GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0005743|mitochondrial inner membrane;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005794|Golgi apparatus;GO:0005811|lipid droplet;","GO:0003674|molecular_function;GO:0003824|catalytic activity;GO:0016829|lyase activity;GO:0043621|protein self-association;GO:0046872|metal ion binding;GO:0051539|4 iron, 4 sulfur cluster binding;","K15045","RSAD2; radical S-adenosyl methionine domain-containing protein 2"]
["ENSRNOG00000013668",1066,89.68819638,457,29.39901025,3.050721627,1.609150542,2.81E-97,{"v":4.13e-96,"d":"4.13E-96"},"up","yes","Capg","protein_coding","chr4:104594753-104611856:+","gi|61556900|ref|NP_001013104.1|",1880,0,"macrophage-capping protein [Rattus norvegicus]","gi|672049919|ref|XM_006236666.2|",1187,0,"PREDICTED: Rattus norvegicus capping protein (actin filament), gelsolin-like (Capg), transcript variant X4, mRNA","Q6AYC4",728,0,"Macrophage-capping protein",".",".",".",".","pfam00626","Gelsolin","Gelsolin repeat.","GO:0007417|central nervous system development;GO:0008154|actin polymerization or depolymerization;GO:0030031|cell projection assembly;GO:0051014|actin filament severing;GO:0051016|barbed-end actin filament capping;GO:0071346|cellular response to interferon-gamma;","GO:0001726|ruffle;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005814|centriole;GO:0015629|actin cytoskeleton;GO:0030027|lamellipodium;GO:0042470|melanosome;GO:0045335|phagocytic vesicle;GO:0072686|mitotic spindle;GO:0090543|Flemming body;","GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0019904|protein domain specific binding;GO:0044877|protein-containing complex binding;GO:0051015|actin filament binding;","K10368","CAPG; capping protein (actin filament), gelsolin-like"]
["ENSRNOG00000069024",1754,147.5732612,1028,66.13169045,2.231505957,1.158017658,{"v":6.19e-97,"d":"6.19E-97"},{"v":9.09e-96,"d":"9.09E-96"},"up","yes","ENSRNOG00000069024","protein_coding","chr10:16681808-16683120:+","gi|537145630|gb|ERE69523.1|",899,{"v":3e-118,"d":"3.00E-118"},"dual specificity protein phosphatase 1-like protein [Cricetulus griseus]","gi|134142819|ref|NM_053769.3|",590,0,"Rattus norvegicus dual specificity phosphatase 1 (Dusp1), mRNA","Q64623",353,{"v":2E-118,"d":"2.00E-118"},"Dual specificity protein phosphatase 1","YBR276c_2",67,{"v":3e-12,"d":"3.00E-12"},"COG2453","pfam00782","DSPc","Dual specificity phosphatase, catalytic domain. Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a \"recognition\" region.",".",".",".",".","."]
["ENSRNOG00000002470",1027,86.4069209,433,27.85507973,3.102016642,1.633206426,{"v":9.02e-96,"d":"9.02E-96"},{"v":1.31e-94,"d":"1.31E-94"},"up","yes","Ifi47","protein_coding","chr10:33285450-33306216:+","gi|672067229|ref|XP_008765884.1|",2158,0,"PREDICTED: interferon gamma inducible protein 47 isoform X2 [Rattus norvegicus]","gi|672067230|ref|XM_006246175.2|",3717,0,"PREDICTED: Rattus norvegicus interferon gamma inducible protein 47 (Ifi47), transcript variant X2, mRNA","Q3T9E4",295,{"v":2E-87,"d":"2.00E-87"},"T-cell-specific guanine nucleotide triphosphate-binding protein 2",".",".",".",".","pfam05049","IIGP","Interferon-inducible GTPase (IIGP). Interferon-inducible GTPase (IIGP) is thought to play a role in in intracellular defence. IIGP is predominantly associated with the Golgi apparatus and also localizes to the endoplasmic reticulum and exerts a distinct role in IFN-induced intracellular membrane trafficking or processing.","GO:0006952|defense response;GO:0035458|cellular response to interferon-beta;","GO:0005789|endoplasmic reticulum membrane;","GO:0003924|GTPase activity;GO:0005525|GTP binding;","K17072","IFI47; interferon gamma inducible protein 47"]
["ENSRNOG00000048315",1161,97.6810469,537,34.54544531,2.827610009,1.499583154,1.32E-95,{"v":1.9E-94,"d":"1.90E-94"},"up","yes","Eif2ak2","protein_coding","chr6:16188979-16224971:+","gi|672055172|ref|XP_008762647.1|",2664,0,"PREDICTED: interferon-induced, double-stranded RNA-activated protein kinase isoform X2 [Rattus norvegicus]","gi|672055171|ref|XM_008764425.1|",3870,0,"PREDICTED: Rattus norvegicus eukaryotic translation initiation factor 2-alpha kinase 2 (Eif2ak2), transcript variant X1, mRNA","Q63184",981,0,"Interferon-induced, double-stranded RNA-activated protein kinase","L138452_1",107,{"v":2e-23,"d":"2.00E-23"},"COG0515","pfam00069","Pkinase","Protein kinase domain.","GO:0001819|positive regulation of cytokine production;GO:0006412|translation;GO:0006468|protein phosphorylation;GO:0009612|response to mechanical stimulus;GO:0009615|response to virus;GO:0009636|response to toxic substance;GO:0010033|response to organic substance;GO:0010998|regulation of translational initiation by eIF2 alpha phosphorylation;GO:0017148|negative regulation of translation;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0030968|endoplasmic reticulum unfolded protein response;GO:0032496|response to lipopolysaccharide;GO:0032722|positive regulation of chemokine production;GO:0032874|positive regulation of stress-activated MAPK cascade;GO:0033197|response to vitamin E;GO:0033689|negative regulation of osteoblast proliferation;GO:0034198|cellular response to amino acid starvation;GO:0035455|response to interferon-alpha;GO:0043065|positive regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0043330|response to exogenous dsRNA;GO:0043410|positive regulation of MAPK cascade;GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0046777|protein autophosphorylation;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051607|defense response to virus;GO:1900225|regulation of NLRP3 inflammasome complex assembly;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1901532|regulation of hematopoietic progenitor cell differentiation;GO:1902033|regulation of hematopoietic stem cell proliferation;GO:1902036|regulation of hematopoietic stem cell differentiation;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0048471|perinuclear region of cytoplasm;","GO:0003725|double-stranded RNA binding;GO:0004672|protein kinase activity;GO:0004694|eukaryotic translation initiation factor 2alpha kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0042802|identical protein binding;","K16195","EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1]"]
["ENSRNOG00000062480",382,32.13967262,29,1.865582707,17.22768575,4.106657008,{"v":1.43e-95,"d":"1.43E-95"},2.05E-94,"up","yes","ENSRNOG00000062480","protein_coding","chr1:69429269-69447438:+","gi|672013100|ref|XP_008772637.1|",1643,0,"PREDICTED: leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X1 [Rattus norvegicus]","gi|672013099|ref|XM_008774415.1|",1779,0,"PREDICTED: Rattus norvegicus leukocyte immunoglobulin-like receptor subfamily B member 4 (LOC103690369), transcript variant X1, mRNA","Q9HCN6",119,{"v":3E-28,"d":"3.00E-28"},"Platelet glycoprotein VI",".",".",".",".","pfam13927","Ig_3","Immunoglobulin domain. This family contains immunoglobulin-like domains.",".",".",".",".","."]
["ENSRNOG00000003486",642,54.01484247,168,10.80751362,4.99789724,2.321321239,{"v":2.73e-95,"d":"2.73E-95"},{"v":3.91e-94,"d":"3.91E-94"},"up","yes","Mnda","protein_coding","chr13:86017892-86034201:-","gi|58865634|ref|NP_001012029.1|",1794,0,"myeloid cell nuclear differentiation antigen [Rattus norvegicus]","gi|58865633|ref|NM_001012029.1|",1302,0,"Rattus norvegicus myeloid cell nuclear differentiation antigen (Mnda), mRNA","P0DOV2",427,{"v":5e-140,"d":"5.00E-140"},"Interferon-activable protein 204",".",".",".",".","pfam02760","HIN","HIN-200/IF120x domain. This domain has no know function. It is found in one or two copies per protein, and is found associated with the PAAD/DAPIN domain pfam02758.","GO:0002218|activation of innate immune response;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006974|cellular response to DNA damage stimulus;GO:0009617|response to bacterium;GO:0030889|negative regulation of B cell proliferation;GO:0032731|positive regulation of interleukin-1 beta production;GO:0035457|cellular response to interferon-alpha;GO:0035458|cellular response to interferon-beta;GO:0043065|positive regulation of apoptotic process;GO:0045669|positive regulation of osteoblast differentiation;GO:0048839|inner ear development;GO:0050853|B cell receptor signaling pathway;","GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005829|cytosol;GO:0042405|nuclear inclusion body;GO:0043231|intracellular membrane-bounded organelle;","GO:0003690|double-stranded DNA binding;GO:0003712|transcription coregulator activity;",".","."]
["ENSRNOG00000008194",803,67.56062072,273,17.56220962,3.846931688,1.943708211,{"v":2.99e-95,"d":"2.99E-95"},4.28E-94,"up","yes","Znfx1","protein_coding","chr3:155764980-155821242:-","gi|114145712|ref|NP_001041325.1|",10388,0,"NFX1-type zinc finger-containing protein 1 [Rattus norvegicus]","gi|114145711|ref|NM_001047860.1|",6059,0,"Rattus norvegicus zinc finger, NFX1-type containing 1 (Znfx1), mRNA","Q8R151",3518,0,"NFX1-type zinc finger-containing protein 1","SPCC1739.03",207,{"v":3e-53,"d":"3.00E-53"},"COG1112","pfam13087","AAA_12","AAA domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.","GO:0031048|chromatin silencing by small RNA;","GO:0031380|nuclear RNA-directed RNA polymerase complex;","GO:0003723|RNA binding;GO:0004386|helicase activity;GO:0008270|zinc ion binding;",".","."]
["ENSRNOG00000001480",618,51.99559602,154,9.90688748,5.248429048,2.391885662,{"v":4.84e-95,"d":"4.84E-95"},{"v":6.86e-94,"d":"6.86E-94"},"up","yes","Ncf1","protein_coding","chr12:22485451-22494646:+","gi|939204643|sp|F1M707.2|NCF1_RAT",2003,0,"RecName: Full=Neutrophil cytosolic factor 1; Short=NCF-1","gi|40254741|ref|NM_053734.2|",2751,0,"Rattus norvegicus neutrophil cytosolic factor 1 (Ncf1), mRNA","F1M707",776,0,"Neutrophil cytosolic factor 1",".",".",".",".","pfam00787","PX","PX domain. PX domains bind to phosphoinositides.","GO:0001878|response to yeast;GO:0001909|leukocyte mediated cytotoxicity;GO:0002679|respiratory burst involved in defense response;GO:0006612|protein targeting to membrane;GO:0006691|leukotriene metabolic process;GO:0006915|apoptotic process;GO:0006954|inflammatory response;GO:0006968|cellular defense response;GO:0008283|cell proliferation;GO:0009617|response to bacterium;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0034614|cellular response to reactive oxygen species;GO:0042554|superoxide anion generation;GO:0042742|defense response to bacterium;GO:0045730|respiratory burst;GO:0045741|positive regulation of epidermal growth factor-activated receptor activity;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045986|negative regulation of smooth muscle contraction;GO:0046330|positive regulation of JNK cascade;GO:0050665|hydrogen peroxide biosynthetic process;GO:0050790|regulation of catalytic activity;GO:0050830|defense response to Gram-positive bacterium;GO:0050832|defense response to fungus;GO:0060264|regulation of respiratory burst involved in inflammatory response;GO:0070946|neutrophil mediated killing of gram-positive bacterium;GO:0070947|neutrophil mediated killing of fungus;GO:0071276|cellular response to cadmium ion;GO:1900745|positive regulation of p38MAPK cascade;GO:1903409|reactive oxygen species biosynthetic process;","GO:0005737|cytoplasm;GO:0005791|rough endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0019898|extrinsic component of membrane;GO:0030425|dendrite;GO:0043020|NADPH oxidase complex;GO:0043025|neuronal cell body;","GO:0016175|superoxide-generating NADPH oxidase activity;GO:0016176|superoxide-generating NADPH oxidase activator activity;GO:0017124|SH3 domain binding;GO:0035091|phosphatidylinositol binding;GO:0043325|phosphatidylinositol-3,4-bisphosphate binding;","K08011","NCF1, P47PHOX; neutrophil cytosolic factor 1"]
["ENSRNOG00000013220",933,78.49820565,369,23.73793169,3.306867956,1.72546544,{"v":4.32e-94,"d":"4.32E-94"},6.08E-93,"up","yes","Arhgap45","protein_coding","chr7:9674897-9690268:-","gi|157820943|ref|NP_001101537.1|",5119,0,"minor histocompatibility protein HA-1 [Rattus norvegicus]","gi|157820942|ref|NM_001108067.1|",3883,0,"Rattus norvegicus histocompatibility (minor) HA-1 (Hmha1), mRNA","Q3TBD2",1873,0,"Rho GTPase-activating protein 45",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0035556|intracellular signal transduction;GO:0090630|activation of GTPase activity;",".","GO:0005096|GTPase activator activity;","K20644","ARHGAP29_45; Rho GTPase-activating protein 29/45"]
["ENSRNOG00000050395",664,55.86581838,186,11.9654615,4.668922997,2.223089795,{"v":1.48e-93,"d":"1.48E-93"},{"v":2.06e-92,"d":"2.06E-92"},"up","yes","Ms4a6bl","protein_coding","chr1:208243559-208257340:+","gi|55741532|ref|NP_001006976.1|",1233,{"v":7e-158,"d":"7.00E-158"},"membrane-spanning 4-domains, subfamily A, member 6B-like [Rattus norvegicus]","gi|298888539|emb|FQ230476.1|",3286,0,"Rattus norvegicus TL0AEA98YI12 mRNA sequence","Q99N09",366,{"v":2E-116,"d":"2.00E-116"},"Membrane-spanning 4-domains subfamily A member 6B",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.",".","GO:0016021|integral component of membrane;",".","K22191","MS4A5_6_7; membrane-spanning 4-domains subfamily A member 5/6/7"]
["ENSRNOG00000000699",396,33.31756638,39,2.508887089,13.27981898,3.731163576,{"v":3.35e-93,"d":"3.35E-93"},{"v":4.64e-92,"d":"4.64E-92"},"up","yes","Selplg","protein_coding","chr12:42796580-42812585:+","gi|61557366|ref|NP_001013248.1|",2026,0,"P-selectin glycoprotein ligand 1 precursor [Rattus norvegicus]","gi|157100914|emb|AM778467.1|",1188,0,"Rattus norvegicus mRNA for P-selectin glycoprotein ligand 1 propeptide precursor (Selplg gene)","Q62170",551,{"v":3e-177,"d":"3.00E-177"},"P-selectin glycoprotein ligand 1",".",".",".",".","pfam05109","Herpes_BLLF1","Herpes virus major outer envelope glycoprotein (BLLF1). This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralizing antibodies in vivo.","GO:0030097|hemopoiesis;GO:0050900|leukocyte migration;GO:0050901|leukocyte tethering or rolling;GO:0050902|leukocyte adhesive activation;GO:0071354|cellular response to interleukin-6;","GO:0001931|uropod;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0044853|plasma membrane raft;",".","K06544","SELPLG, CD162; selectin P ligand"]
["ENSRNOG00000069208",337,28.35358553,5,0.321652191,88.14982871,6.461885861,2.36E-92,3.25E-91,"up","yes","ENSRNOG00000069208","pseudogene","chr3:2233522-2234359:-","gi|672034032|ref|XP_008756887.1|",577,{"v":1e-69,"d":"1.00E-69"},"PREDICTED: serine/arginine repetitive matrix protein 1-like [Rattus norvegicus]","gi|374429560|ref|NR_046239.1|",674,0,"Rattus norvegicus 45S pre-ribosomal RNA (Rn45s), ribosomal RNA",".",".",".",".",".",".",".",".","pfam07420","DUF1509","Protein of unknown function (DUF1509). This family consists of several uncharacterized viral proteins from the Marek's disease-like viruses. Members of this family are typically around 400 residues in length. The function of this family is unknown.",".",".",".",".","."]
["ENSRNOG00000017241",1256,105.6738974,629,40.46384562,2.61156338,1.384913717,{"v":7.19e-92,"d":"7.19E-92"},9.86E-91,"up","yes","Dpcd","protein_coding","chr1:244408785-244426888:+","gi|564333908|ref|XP_006231512.1|",1041,{"v":9e-137,"d":"9.00E-137"},"PREDICTED: protein DPCD isoform X1 [Rattus norvegicus]","gi|672040366|ref|XM_006231450.2|",1185,0,"PREDICTED: Rattus norvegicus deleted in primary ciliary dyskinesia (Dpcd), transcript variant X1, mRNA","Q6AYM4",405,{"v":3e-138,"d":"3.00E-138"},"Protein DPCD",".",".",".",".","pfam14913","DPCD","DPCD protein family. This protein is a found in eukaryotes and a mutation in this protein is thought to cause Primary Ciliary Dyskinesia (PCD). This protein is 203 amino acids in length, 23 kDa in size and its function remains unknown. The gene that encodes this protein is a candidate gene for PCD and is expressed during ciliogenesis. PCD affects the airways and reproductive organs, and probing Northern blots show DPCD expression in humans is highest in the testes. Additionally, there is no indication of major splice variants.","GO:0003351|epithelial cilium movement;GO:0007283|spermatogenesis;GO:0007368|determination of left/right symmetry;GO:0021591|ventricular system development;GO:0021670|lateral ventricle development;GO:0021678|third ventricle development;GO:0030317|flagellated sperm motility;GO:0060972|left/right pattern formation;","GO:0005576|extracellular region;",".","K20800","DPCD; protein DPCD"]
["ENSRNOG00000017980",498,41.89936379,93,5.982730751,7.003384496,2.808052296,1.88E-91,2.56E-90,"up","yes","Itgal","protein_coding","chr1:181918183-181955732:+","gi|564331001|ref|XP_006230331.1|",5895,0,"PREDICTED: integrin alpha-L isoform X1 [Rattus norvegicus]","gi|672038444|ref|XM_006230269.2|",4356,0,"PREDICTED: Rattus norvegicus integrin, alpha L (Itgal), transcript variant X1, mRNA","P24063",1983,0,"Integrin alpha-L",".",".",".",".","pfam08441","Integrin_alpha2","Integrin alpha. This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.","GO:0002291|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007159|leukocyte cell-cell adhesion;GO:0007160|cell-matrix adhesion;GO:0007166|cell surface receptor signaling pathway;GO:0007229|integrin-mediated signaling pathway;GO:0022407|regulation of cell-cell adhesion;GO:0022409|positive regulation of cell-cell adhesion;GO:0035683|memory T cell extravasation;GO:0042102|positive regulation of T cell proliferation;GO:0043113|receptor clustering;GO:0050798|activated T cell proliferation;GO:0050850|positive regulation of calcium-mediated signaling;GO:0098609|cell-cell adhesion;","GO:0001772|immunological synapse;GO:0005911|cell-cell junction;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0034687|integrin alphaL-beta2 complex;","GO:0030369|ICAM-3 receptor activity;GO:0044877|protein-containing complex binding;GO:0046872|metal ion binding;GO:0050839|cell adhesion molecule binding;","K05718","ITGAL, CD11a; integrin alpha L"]
["ENSRNOG00000007529",906,76.22655339,362,23.28761862,3.273265276,1.710730528,{"v":2.37e-90,"d":"2.37E-90"},{"v":3.19e-89,"d":"3.19E-89"},"up","yes","Bmf","protein_coding","chr3:105499538-105520145:-","gi|564342296|ref|XP_006234785.1|",1336,{"v":1E-168,"d":"1.00E-168"},"PREDICTED: bcl-2-modifying factor isoform X2 [Rattus norvegicus]","gi|672046480|ref|XM_006234723.2|",4660,0,"PREDICTED: Rattus norvegicus Bcl2 modifying factor (Bmf), transcript variant X2, mRNA","Q8K589",374,{"v":3e-118,"d":"3.00E-118"},"Bcl-2-modifying factor",".",".",".",".","pfam15185","BMF","Bcl-2-modifying factor, apoptosis. BMF is thought to play a role in inducing apoptosis. It is thought to bind to Bcl-2 proteins. This family of proteins is found in eukaryotes. Proteins in this family are typically between 75 and 190 amino acids in length. There are two conserved sequence motifs: GNA and DQF.","GO:0008150|biological_process;GO:0009267|cellular response to starvation;GO:0010507|negative regulation of autophagy;GO:0031334|positive regulation of protein complex assembly;GO:0034644|cellular response to UV;GO:0043065|positive regulation of apoptotic process;GO:0043276|anoikis;GO:0090200|positive regulation of release of cytochrome c from mitochondria;GO:1904093|negative regulation of autophagic cell death;GO:2001234|negative regulation of apoptotic signaling pathway;GO:2001235|positive regulation of apoptotic signaling pathway;","GO:0001669|acrosomal vesicle;GO:0005737|cytoplasm;GO:0015629|actin cytoskeleton;GO:0016459|myosin complex;","GO:0003674|molecular_function;","K17460","BMF; Bcl-2-modifying factor"]
["ENSRNOG00000014303",1928,162.212798,1238,79.64108247,2.036798006,1.026302912,{"v":8.73e-88,"d":"8.73E-88"},1.13E-86,"up","yes","Lrp11","protein_coding","chr1:2079438-2108110:+","gi|31542055|ref|NP_766372.1|",1810,0,"low-density lipoprotein receptor-related protein 11 precursor [Mus musculus]","gi|157823146|ref|NM_001106217.1|",2038,0,"Rattus norvegicus LDL receptor related protein 11 (Lrp11), mRNA","Q8CB67",701,0,"Low-density lipoprotein receptor-related protein 11",".",".",".",".","pfam07502","MANEC","MANEC domain. This region of similarity, comprising 8 conserved cysteines, is found in the N-terminal region of several membrane-associated and extracellular proteins. Although formerly called MANSC (for motif at N terminus with seven cysteines) it has now been renamed by MANEC (motif at N terminus with eight cysteines) by Richard Mitter and Stephen Fitzgerald after the discovery of an eighth conserved cysteine. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors.","GO:0009408|response to heat;GO:0009409|response to cold;GO:0009414|response to water deprivation;GO:0009612|response to mechanical stimulus;GO:0033555|multicellular organismal response to stress;GO:0035902|response to immobilization stress;GO:0042594|response to starvation;","GO:0016021|integral component of membrane;","GO:0051219|phosphoprotein binding;",".","."]
["ENSRNOG00000019430",642,54.01484247,187,12.02979194,4.490089499,2.166744202,{"v":9.56e-88,"d":"9.56E-88"},1.24E-86,"up","yes","Coro1a","protein_coding","chr1:181295562-181300534:-","gi|18426834|ref|NP_569095.1|",2455,0,"coronin-1A [Rattus norvegicus]","gi|298889768|emb|FQ226941.1|",1610,0,"Rattus norvegicus TL0AEA15YO22 mRNA sequence","Q91ZN1",950,0,"Coronin-1A",".",".",".",".","pfam08954","DUF1900","Domain of unknown function (DUF1900). This domain is predominantly found in the structural protein coronin, and is duplicated in some sequences. It has no known function.","GO:0001845|phagolysosome assembly;GO:0006816|calcium ion transport;GO:0006909|phagocytosis;GO:0007015|actin filament organization;GO:0008064|regulation of actin polymerization or depolymerization;GO:0008150|biological_process;GO:0008360|regulation of cell shape;GO:0016477|cell migration;GO:0030036|actin cytoskeleton organization;GO:0030217|T cell differentiation;GO:0030335|positive regulation of cell migration;GO:0030595|leukocyte chemotaxis;GO:0030833|regulation of actin filament polymerization;GO:0031339|negative regulation of vesicle fusion;GO:0031589|cell-substrate adhesion;GO:0032796|uropod organization;GO:0032956|regulation of actin cytoskeleton organization;GO:0034097|response to cytokine;GO:0038180|nerve growth factor signaling pathway;GO:0042102|positive regulation of T cell proliferation;GO:0043029|T cell homeostasis;GO:0043320|natural killer cell degranulation;GO:0043524|negative regulation of neuron apoptotic process;GO:0048873|homeostasis of number of cells within a tissue;GO:0050870|positive regulation of T cell activation;GO:0050918|positive chemotaxis;GO:0051126|negative regulation of actin nucleation;GO:0051279|regulation of release of sequestered calcium ion into cytosol;GO:0061502|early endosome to recycling endosome transport;GO:0071353|cellular response to interleukin-4;","GO:0001772|immunological synapse;GO:0001891|phagocytic cup;GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005769|early endosome;GO:0005829|cytosol;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0015629|actin cytoskeleton;GO:0030027|lamellipodium;GO:0030424|axon;GO:0030670|phagocytic vesicle membrane;GO:0030864|cortical actin cytoskeleton;GO:0031252|cell leading edge;GO:0032426|stereocilium tip;GO:0032991|protein-containing complex;GO:0045202|synapse;GO:0045335|phagocytic vesicle;GO:0098978|glutamatergic synapse;","GO:0003674|molecular_function;GO:0003779|actin binding;GO:0003785|actin monomer binding;GO:0008022|protein C-terminus binding;GO:0008092|cytoskeletal protein binding;GO:0032036|myosin heavy chain binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0043548|phosphatidylinositol 3-kinase binding;GO:0051015|actin filament binding;","K13882","CORO1A; coronin-1A"]
["ENSRNOG00000008487",1406,118.2941877,778,50.04908091,2.363563637,1.240963709,6.64E-87,{"v":8.53e-86,"d":"8.53E-86"},"up","yes","Amotl2","protein_coding","chr8:103302992-103318910:+","gi|564365265|ref|XP_006243742.1|",2952,0,"PREDICTED: angiomotin-like protein 2 isoform X1 [Rattus norvegicus]","gi|672063141|ref|XM_006243680.2|",3292,0,"PREDICTED: Rattus norvegicus angiomotin like 2 (Amotl2), transcript variant X1, mRNA","G3V735",1092,0,"Angiomotin-like protein 2",".",".",".",".","pfam12240","Angiomotin_C","Angiomotin C terminal. This domain family is found in eukaryotes, and is typically between 197 and 211 amino acids in length. This family is the C terminal region of angiomotin. Angiomotin regulates the action of angiogenesis inhibitor angiostatin. The C terminal region of angiomotin appears to be involved in directing the protein chemotactically.","GO:0001525|angiogenesis;GO:0003365|establishment of cell polarity involved in ameboidal cell migration;GO:0016055|Wnt signaling pathway;GO:0030036|actin cytoskeleton organization;GO:0030334|regulation of cell migration;GO:0035329|hippo signaling;","GO:0005886|plasma membrane;GO:0005923|bicellular tight junction;GO:0016324|apical plasma membrane;GO:0031410|cytoplasmic vesicle;GO:0055037|recycling endosome;","GO:0042802|identical protein binding;","K06104","AMOTL; angiomotin like"]
["ENSRNOG00000011820",1078,90.6978196,507,32.61553216,2.780816795,1.4755087,{"v":7.65e-87,"d":"7.65E-87"},{"v":9.8e-86,"d":"9.80E-86"},"up","yes","Acp3","protein_coding","chr8:104905586-104954236:-","gi|201025407|ref|NP_001128373.1|",2024,0,"prostatic acid phosphatase long isoform precursor [Rattus norvegicus]","gi|201025406|ref|NM_001134901.1|",1242,0,"Rattus norvegicus acid phosphatase, prostate (Acpp), transcript variant 1, mRNA","P20646",717,0,"Prostatic acid phosphatase",".",".",".",".","pfam00328","His_Phos_2","Histidine phosphatase superfamily (branch 2). The histidine phosphatase superfamily is so named because catalysis centres on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches.The smaller branch 2 contains predominantly eukaryotic proteins. The catalytic functions in members include phytase, glucose-1-phosphatase and multiple inositol polyphosphate phosphatase. The in vivo roles of the mammalian acid phosphatases in branch 2 are not fully understood, although activity against lysophosphatidic acid and tyrosine-phosphorylated proteins has been demonstrated.","GO:0006144|purine nucleobase metabolic process;GO:0006772|thiamine metabolic process;GO:0007040|lysosome organization;GO:0009117|nucleotide metabolic process;GO:0016311|dephosphorylation;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0046085|adenosine metabolic process;GO:0051930|regulation of sensory perception of pain;GO:0060168|positive regulation of adenosine receptor signaling pathway;","GO:0005615|extracellular space;GO:0005764|lysosome;GO:0005765|lysosomal membrane;GO:0005771|multivesicular body;GO:0005886|plasma membrane;GO:0012506|vesicle membrane;GO:0016021|integral component of membrane;GO:0030141|secretory granule;GO:0030175|filopodium;GO:0031985|Golgi cisterna;GO:0045177|apical part of cell;","GO:0003993|acid phosphatase activity;GO:0004725|protein tyrosine phosphatase activity;GO:0008253|5'-nucleotidase activity;GO:0016791|phosphatase activity;GO:0033265|choline binding;GO:0042131|thiamine phosphate phosphatase activity;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0052642|lysophosphatidic acid phosphatase activity;","K19283","ACPP; prostatic acid phosphatase [EC:3.1.3.2 3.1.3.5]"]
["ENSRNOG00000007350",572,48.12537367,146,9.392243975,5.123948419,2.357255953,1.21E-86,{"v":1.54e-85,"d":"1.54E-85"},"up","yes","Rac2","protein_coding","chr7:110116260-110128720:-","gi|537235276|gb|ERE85167.1|",846,{"v":9e-107,"d":"9.00E-107"},"ras-related C3 botulinum toxin substrate 1-like protein [Cricetulus griseus]","gi|672060205|ref|XM_006242028.2|",587,0,"PREDICTED: Rattus norvegicus ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) (Rac2), transcript variant X1, mRNA","Q05144",311,{"v":3e-101,"d":"3.00E-101"},"Ras-related C3 botulinum toxin substrate 2",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0006935|chemotaxis;GO:0007015|actin filament organization;GO:0007163|establishment or maintenance of cell polarity;GO:0007186|G protein-coupled receptor signaling pathway;GO:0008045|motor neuron axon guidance;GO:0008284|positive regulation of cell proliferation;GO:0008360|regulation of cell shape;GO:0010592|positive regulation of lamellipodium assembly;GO:0010810|regulation of cell-substrate adhesion;GO:0016601|Rac protein signal transduction;GO:0030031|cell projection assembly;GO:0030036|actin cytoskeleton organization;GO:0030865|cortical cytoskeleton organization;GO:0032956|regulation of actin cytoskeleton organization;GO:0042129|regulation of T cell proliferation;GO:0043304|regulation of mast cell degranulation;GO:0043652|engulfment of apoptotic cell;GO:0045453|bone resorption;GO:0050790|regulation of catalytic activity;GO:0060263|regulation of respiratory burst;GO:0060753|regulation of mast cell chemotaxis;GO:0071593|lymphocyte aggregation;GO:0090023|positive regulation of neutrophil chemotaxis;GO:1902622|regulation of neutrophil migration;GO:1903955|positive regulation of protein targeting to mitochondrion;","GO:0005635|nuclear envelope;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0005938|cell cortex;GO:0016020|membrane;GO:0030027|lamellipodium;GO:0031410|cytoplasmic vesicle;GO:0042995|cell projection;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0019887|protein kinase regulator activity;GO:0019901|protein kinase binding;","K07860","RAC2; Ras-related C3 botulinum toxin substrate 2"]
["ENSRNOG00000026647",1154,97.09210002,574,36.92567152,2.629392941,1.394729757,{"v":1.87e-85,"d":"1.87E-85"},2.34E-84,"up","yes","Cxcl16","protein_coding","chr10:55166723-55171592:-","gi|62945312|ref|NP_001017478.1|",1018,{"v":2e-130,"d":"2.00E-130"},"C-X-C motif chemokine 16 precursor [Rattus norvegicus]","gi|65993504|gb|DQ025528.1|",1255,0,"Rattus norvegicus CXCL16 (Cxcl16) mRNA, complete cds","Q6AXU5",396,{"v":5e-132,"d":"5.00E-132"},"C-X-C motif chemokine 16",".",".",".",".","pfam15455","Pro-rich_19","Proline-rich 19. This family includes proline-rich protein 19.","GO:0006898|receptor-mediated endocytosis;GO:0007165|signal transduction;GO:0010818|T cell chemotaxis;GO:0030307|positive regulation of cell growth;GO:0030335|positive regulation of cell migration;GO:0034097|response to cytokine;GO:0034341|response to interferon-gamma;GO:0034612|response to tumor necrosis factor;GO:0071222|cellular response to lipopolysaccharide;","GO:0005615|extracellular space;GO:0016021|integral component of membrane;","GO:0005041|low-density lipoprotein particle receptor activity;GO:0005044|scavenger receptor activity;GO:0008009|chemokine activity;GO:0042379|chemokine receptor binding;","K10035","CXCL16; C-X-C motif chemokine 16"]
["ENSRNOG00000014653",451,37.94500616,80,5.146435055,7.373066162,2.882264703,3.56E-85,{"v":4.43e-84,"d":"4.43E-84"},"up","yes","Arl11","protein_coding","chr15:35480018-35496596:+","gi|61740633|ref|NP_001013451.1|",810,{"v":2E-100,"d":"2.00E-100"},"ADP-ribosylation factor-like protein 11 [Rattus norvegicus]","gi|672078347|ref|XM_006252135.2|",2046,0,"PREDICTED: Rattus norvegicus ADP-ribosylation factor-like 11 (Arl11), transcript variant X1, mRNA","Q5BK71",316,{"v":6E-102,"d":"6.00E-102"},"ADP-ribosylation factor-like protein 11",".",".",".",".","pfam00025","Arf","ADP-ribosylation factor family. Pfam combines a number of different Prosite families together","GO:0002244|hematopoietic progenitor cell differentiation;GO:0006886|intracellular protein transport;GO:0016192|vesicle-mediated transport;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;","GO:0003924|GTPase activity;GO:0005525|GTP binding;","K07959","ARL11; ADP-ribosylation factor-like protein 11"]
["ENSRNOG00000046216",461,38.78635885,86,5.532417684,7.010743053,2.80956736,{"v":7.61e-85,"d":"7.61E-85"},{"v":9.41e-84,"d":"9.41E-84"},"up","yes","RGD1559482","protein_coding","chr10:100156238-100182647:+","gi|564375252|ref|XP_006247801.1|",1012,{"v":4e-132,"d":"4.00E-132"},"PREDICTED: CMRF35-like molecule isoform X1 [Rattus norvegicus]","gi|672070034|ref|XM_006247739.2|",639,0,"PREDICTED: Rattus norvegicus immunoglobulin superfamily, member 7 (Igsf7), transcript variant X2, mRNA","Q7TSN2",261,{"v":7e-82,"d":"7.00E-82"},"CMRF35-like molecule",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0001819|positive regulation of cytokine production;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;",".","K06719","CD300; CD300 antigen"]
["ENSRNOG00000001431",539,45.3489098,135,8.684609155,5.221755981,2.38453504,{"v":7.63e-83,"d":"7.63E-83"},{"v":9.27e-82,"d":"9.27E-82"},"up","yes","Rasa4","protein_coding","chr12:20552806-20580147:-","gi|293341124|ref|XP_002724855.1|",4054,0,"PREDICTED: ras GTPase-activating protein 4 [Rattus norvegicus]","gi|672026669|ref|XM_002724809.3|",2805,0,"PREDICTED: Rattus norvegicus RAS p21 protein activator 4 (Rasa4), mRNA","Q6PFQ7",1483,0,"Ras GTPase-activating protein 4",".",".",".",".","pfam00616","RasGAP","GTPase-activator protein for Ras-like GTPase. All alpha-helical domain that accelerates the GTPase activity of Ras, thereby \"switching\" it into an \"off\" position.","GO:0035556|intracellular signal transduction;GO:0043087|regulation of GTPase activity;GO:0046580|negative regulation of Ras protein signal transduction;GO:0071277|cellular response to calcium ion;",".","GO:0005096|GTPase activator activity;GO:0005543|phospholipid binding;GO:0046872|metal ion binding;","K17630","RASA4, CAPRI; Ras GTPase-activating protein 4"]
["ENSRNOG00000006231",352,29.61561456,36,2.315895775,12.78797383,3.676715792,{"v":3.31e-82,"d":"3.31E-82"},3.97E-81,"up","yes","Ptpro","protein_coding","chr4:170164431-170374771:+","gi|8394227|ref|NP_059032.1|",6061,0,"receptor-type tyrosine-protein phosphatase O precursor [Rattus norvegicus]","gi|8394226|ref|NM_017336.1|",4850,0,"Rattus norvegicus protein tyrosine phosphatase, receptor type, O (Ptpro), mRNA","E9Q612",2241,0,"Receptor-type tyrosine-protein phosphatase O","SPAC11E3.09",168,{"v":2e-44,"d":"2.00E-44"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0000902|cell morphogenesis;GO:0002548|monocyte chemotaxis;GO:0003093|regulation of glomerular filtration;GO:0003105|negative regulation of glomerular filtration;GO:0007399|nervous system development;GO:0007411|axon guidance;GO:0030032|lamellipodium assembly;GO:0032835|glomerulus development;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0036060|slit diaphragm assembly;GO:0050807|regulation of synapse organization;GO:0072112|glomerular visceral epithelial cell differentiation;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:1990264|peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity;","GO:0005886|plasma membrane;GO:0016324|apical plasma membrane;GO:0016328|lateral plasma membrane;GO:0043197|dendritic spine;GO:0098978|glutamatergic synapse;GO:0098982|GABA-ergic synapse;GO:0099061|integral component of postsynaptic density membrane;","GO:0004725|protein tyrosine phosphatase activity;GO:0017147|Wnt-protein binding;GO:0042803|protein homodimerization activity;GO:0045296|cadherin binding;","K18035","PTPRO; receptor-type tyrosine-protein phosphatase O [EC:3.1.3.48]"]
["ENSRNOG00000048222",622,52.3321371,190,12.22278326,4.281523775,2.098124337,{"v":9.17e-82,"d":"9.17E-82"},{"v":1.1e-80,"d":"1.10E-80"},"up","yes","Nlrc5","protein_coding","chr19:10477628-10562121:-","gi|293343229|ref|XP_001062196.2|",9158,0,"PREDICTED: protein NLRC5 isoform X1 [Rattus norvegicus]","gi|672031046|ref|XM_001062196.4|",7035,0,"PREDICTED: Rattus norvegicus NLR family, CARD domain containing 5 (Nlrc5), transcript variant X1, mRNA","C3VPR6",2578,0,"Protein NLRC5",".",".",".",".","pfam05729","NACHT","NACHT domain. This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.","GO:0009617|response to bacterium;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0043549|regulation of kinase activity;GO:0045087|innate immune response;GO:0045345|positive regulation of MHC class I biosynthetic process;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051607|defense response to virus;GO:0060335|positive regulation of interferon-gamma-mediated signaling pathway;GO:0060339|negative regulation of type I interferon-mediated signaling pathway;GO:0060340|positive regulation of type I interferon-mediated signaling pathway;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0005829|cytosol;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;","K22615","NLRC5, NOD4; NLR family CARD domain containing 5"]
["ENSRNOG00000008048",1828,153.7992711,1193,76.74621275,2.003998185,1.002881202,{"v":2.73e-80,"d":"2.73E-80"},{"v":3.21e-79,"d":"3.21E-79"},"up","yes","Plscr2","protein_coding","chr8:92784356-92804692:+","gi|17105346|ref|NP_476542.1|",1291,{"v":1E-172,"d":"1.00E-172"},"phospholipid scramblase 1 [Rattus norvegicus]","gi|17105345|ref|NM_057194.1|",1536,0,"Rattus norvegicus phospholipid scramblase 1 (Plscr1), mRNA","P58195",501,{"v":3e-174,"d":"3.00E-174"},"Phospholipid scramblase 1",".",".",".",".","pfam03803","Scramblase","Scramblase. Scramblase is palmitoylated and contains a potential protein kinase C phosphorylation site. Scramblase exhibits Ca2+-activated phospholipid scrambling activity in vitro. There are also possible SH3 and WW binding motifs. Scramblase is involved in the redistribution of phospholipids after cell activation or injury.","GO:0006659|phosphatidylserine biosynthetic process;GO:0006915|apoptotic process;GO:0006953|acute-phase response;GO:0006955|immune response;GO:0010288|response to lead ion;GO:0010628|positive regulation of gene expression;GO:0015914|phospholipid transport;GO:0017121|phospholipid scrambling;GO:0030099|myeloid cell differentiation;GO:0032091|negative regulation of protein binding;GO:0033003|regulation of mast cell activation;GO:0035455|response to interferon-alpha;GO:0035456|response to interferon-beta;GO:0043065|positive regulation of apoptotic process;GO:0045071|negative regulation of viral genome replication;GO:0045089|positive regulation of innate immune response;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046718|viral entry into host cell;GO:0050765|negative regulation of phagocytosis;GO:0051607|defense response to virus;GO:0060368|regulation of Fc receptor mediated stimulatory signaling pathway;GO:0070782|phosphatidylserine exposure on apoptotic cell surface;GO:0071222|cellular response to lipopolysaccharide;GO:0071345|cellular response to cytokine stimulus;GO:0090305|nucleic acid phosphodiester bond hydrolysis;GO:0097193|intrinsic apoptotic signaling pathway;GO:1902231|positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:1905820|positive regulation of chromosome separation;GO:2000373|positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0045121|membrane raft;GO:0048471|perinuclear region of cytoplasm;GO:0062023|collagen-containing extracellular matrix;","GO:0000287|magnesium ion binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0001618|virus receptor activity;GO:0003677|DNA binding;GO:0004518|nuclease activity;GO:0005154|epidermal growth factor receptor binding;GO:0005509|calcium ion binding;GO:0008270|zinc ion binding;GO:0017124|SH3 domain binding;GO:0017128|phospholipid scramblase activity;GO:0019899|enzyme binding;GO:0032791|lead ion binding;GO:0042609|CD4 receptor binding;GO:0045340|mercury ion binding;",".","."]
["ENSRNOG00000010666",352,29.61561456,1,0.064330438,460.3670579,8.846640793,2.18E-79,{"v":2.53e-78,"d":"2.53E-78"},"up","yes","Ccn5","protein_coding","chr3:152491220-152502636:+","gi|149042986|gb|EDL96560.1|",1126,{"v":4e-148,"d":"4.00E-148"},"WNT1 inducible signaling pathway protein 2 [Rattus norvegicus]","gi|13928801|ref|NM_031590.1|",1630,0,"Rattus norvegicus WNT1 inducible signaling pathway protein 2 (Wisp2), mRNA","Q9Z0G4",423,{"v":7e-144,"d":"7.00E-144"},"WNT1-inducible-signaling pathway protein 2",".",".",".",".","pfam00219","IGFBP","Insulin-like growth factor binding protein.","GO:0001558|regulation of cell growth;GO:0007155|cell adhesion;GO:0007165|signal transduction;GO:0008285|negative regulation of cell proliferation;GO:0060548|negative regulation of cell death;","GO:0002102|podosome;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0031012|extracellular matrix;","GO:0005178|integrin binding;GO:0005515|protein binding;GO:0005520|insulin-like growth factor binding;GO:0008201|heparin binding;","K23089","CCN5, WISP2; CCN family member 5"]
["ENSRNOG00000033215",938,78.91888199,427,27.4690971,2.873006043,1.522561028,{"v":2.51e-79,"d":"2.51E-79"},{"v":2.89e-78,"d":"2.89E-78"},"up","yes","RT1-Db1","protein_coding","chr20:4548666-4558258:-","gi|57114286|ref|NP_001008884.1|",1137,{"v":2e-139,"d":"2.00E-139"},"rano class II histocompatibility antigen, D-1 beta chain precursor [Rattus norvegicus]","gi|89214481|gb|AC120734.5|",4227,0,"Rattus norvegicus BAC CH230-220D1 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P18211",399,{"v":9e-126,"d":"9.00E-126"},"Rano class II histocompatibility antigen, D-1 beta chain",".",".",".",".","pfam00969","MHC_II_beta","Class II histocompatibility antigen, beta domain.","GO:0001916|positive regulation of T cell mediated cytotoxicity;GO:0001934|positive regulation of protein phosphorylation;GO:0002250|adaptive immune response;GO:0002381|immunoglobulin production involved in immunoglobulin mediated immune response;GO:0002437|inflammatory response to antigenic stimulus;GO:0002469|myeloid dendritic cell antigen processing and presentation;GO:0002491|antigen processing and presentation of endogenous peptide antigen via MHC class II;GO:0002503|peptide antigen assembly with MHC class II protein complex;GO:0002504|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;GO:0002842|positive regulation of T cell mediated immune response to tumor cell;GO:0002862|negative regulation of inflammatory response to antigenic stimulus;GO:0006955|immune response;GO:0006959|humoral immune response;GO:0007165|signal transduction;GO:0010033|response to organic substance;GO:0016045|detection of bacterium;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030225|macrophage differentiation;GO:0032653|regulation of interleukin-10 production;GO:0032673|regulation of interleukin-4 production;GO:0032689|negative regulation of interferon-gamma production;GO:0032831|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0033674|positive regulation of kinase activity;GO:0034341|response to interferon-gamma;GO:0035774|positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0042088|T-helper 1 type immune response;GO:0042130|negative regulation of T cell proliferation;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043382|positive regulation of memory T cell differentiation;GO:0043410|positive regulation of MAPK cascade;GO:0045622|regulation of T-helper cell differentiation;GO:0045657|positive regulation of monocyte differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0046598|positive regulation of viral entry into host cell;GO:0050852|T cell receptor signaling pathway;GO:0050870|positive regulation of T cell activation;GO:0051262|protein tetramerization;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071548|response to dexamethasone;GO:2000516|positive regulation of CD4-positive, alpha-beta T cell activation;","GO:0001772|immunological synapse;GO:0005575|cellular_component;GO:0005765|lysosomal membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0031902|late endosome membrane;GO:0042613|MHC class II protein complex;","GO:0003674|molecular_function;GO:0023026|MHC class II protein complex binding;GO:0030247|polysaccharide binding;GO:0032395|MHC class II receptor activity;GO:0042605|peptide antigen binding;GO:0042608|T cell receptor binding;GO:0042609|CD4 receptor binding;","K06752","MHC2; MHC class II antigen"]
["ENSRNOG00000016712",898,75.55347124,397,25.53918396,2.958335371,1.564785612,{"v":4.69e-79,"d":"4.69E-79"},{"v":5.39e-78,"d":"5.39E-78"},"up","yes","Lhcgr","protein_coding","chr6:5661871-5724521:+","gi|6981160|ref|NP_037110.1|",3342,0,"lutropin-choriogonadotropic hormone receptor precursor [Rattus norvegicus]","gi|6981159|ref|NM_012978.1|",2670,0,"Rattus norvegicus luteinizing hormone/choriogonadotropin receptor (Lhcgr), mRNA","P16235",1291,0,"Lutropin-choriogonadotropic hormone receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001541|ovarian follicle development;GO:0006622|protein targeting to lysosome;GO:0007188|adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007190|activation of adenylate cyclase activity;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007283|spermatogenesis;GO:0007417|central nervous system development;GO:0008584|male gonad development;GO:0008585|female gonad development;GO:0009410|response to xenobiotic stimulus;GO:0009755|hormone-mediated signaling pathway;GO:0010524|positive regulation of calcium ion transport into cytosol;GO:0022602|ovulation cycle process;GO:0032962|positive regulation of inositol trisphosphate biosynthetic process;GO:0034699|response to luteinizing hormone;GO:0042700|luteinizing hormone signaling pathway;GO:0046544|development of secondary male sexual characteristics;GO:0046886|positive regulation of hormone biosynthetic process;GO:0050482|arachidonic acid secretion;GO:0050810|regulation of steroid biosynthetic process;GO:0050850|positive regulation of calcium-mediated signaling;GO:0050890|cognition;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;GO:0060065|uterus development;GO:0071371|cellular response to gonadotropin stimulus;GO:0071373|cellular response to luteinizing hormone stimulus;GO:0072520|seminiferous tubule development;GO:0090030|regulation of steroid hormone biosynthetic process;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0005768|endosome;GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0031233|intrinsic component of external side of plasma membrane;GO:0043235|receptor complex;","GO:0004964|luteinizing hormone receptor activity;GO:0008528|G protein-coupled peptide receptor activity;GO:0017046|peptide hormone binding;GO:0035472|choriogonadotropin hormone receptor activity;GO:0038106|choriogonadotropin hormone binding;GO:0042802|identical protein binding;GO:0051117|ATPase binding;","K04248","LHCGR; lutropin-choriogonadotropic hormone receptor"]
["ENSRNOG00000042825",538,45.26477453,145,9.327913537,4.852615148,2.278762447,{"v":1.94e-78,"d":"1.94E-78"},{"v":2.2e-77,"d":"2.20E-77"},"up","yes","Cd300le","protein_coding","chr10:100271036-100280299:-","gi|320498033|ref|NP_001189392.1|",945,{"v":3e-126,"d":"3.00E-126"},"Cd300 molecule-like family member E precursor [Rattus norvegicus]","gi|320498032|ref|NM_001202463.1|",691,0,"Rattus norvegicus Cd300 molecule-like family member E (Cd300le), mRNA","Q6SJQ5",303,{"v":1e-101,"d":"1.00E-101"},"CMRF35-like molecule 3",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004888|transmembrane signaling receptor activity;","K20395","CD300B_D_F; CO300B/D/F antigen"]
["ENSRNOG00000003745",394,33.14929585,63,4.052817606,8.179320925,3.031981071,{"v":2.48e-78,"d":"2.48E-78"},{"v":2.8e-77,"d":"2.80E-77"},"up","yes","Atf3","protein_coding","chr13:102751321-102764631:-","gi|537158431|gb|ERE73051.1|",881,{"v":8e-112,"d":"8.00E-112"},"cyclic AMP-dependent transcription factor ATF-3-like protein [Cricetulus griseus]","gi|401709968|ref|NM_012912.2|",1888,0,"Rattus norvegicus activating transcription factor 3 (Atf3), mRNA","P29596",342,{"v":9e-113,"d":"9.00E-113"},"Cyclic AMP-dependent transcription factor ATF-3",".",".",".",".","pfam00170","bZIP_1","bZIP transcription factor. The Pfam entry includes the basic region and the leucine zipper region.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001709|cell fate determination;GO:0006094|gluconeogenesis;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008284|positive regulation of cell proliferation;GO:0010628|positive regulation of gene expression;GO:0030968|endoplasmic reticulum unfolded protein response;GO:0034198|cellular response to amino acid starvation;GO:0035914|skeletal muscle cell differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:1903984|positive regulation of TRAIL-activated apoptotic signaling pathway;GO:1990440|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:1990622|CHOP-ATF3 complex;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0046982|protein heterodimerization activity;GO:1990837|sequence-specific double-stranded DNA binding;","K09032","ATF3, LRF1; activating transcription factor 3"]
["ENSRNOG00000009211",321,27.00742124,28,1.801252269,14.99369172,3.90628374,3.05E-78,{"v":3.44e-77,"d":"3.44E-77"},"up","yes","C3ar1","protein_coding","chr4:156075389-156084701:-","gi|564348849|ref|XP_006237376.1|",2466,0,"PREDICTED: C3a anaphylatoxin chemotactic receptor isoform X1 [Rattus norvegicus]","gi|14091739|ref|NM_032060.1|",1978,0,"Rattus norvegicus complement component 3a receptor 1 (C3ar1), mRNA","O55197",945,0,"C3a anaphylatoxin chemotactic receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0002430|complement receptor mediated signaling pathway;GO:0002462|tolerance induction to nonself antigen;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0008217|regulation of blood pressure;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0010759|positive regulation of macrophage chemotaxis;GO:0030335|positive regulation of cell migration;GO:0045766|positive regulation of angiogenesis;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0051482|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway;GO:0072126|positive regulation of glomerular mesangial cell proliferation;GO:0090023|positive regulation of neutrophil chemotaxis;GO:2000573|positive regulation of DNA biosynthetic process;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0001850|complement component C3a binding;GO:0004875|complement receptor activity;GO:0004876|complement component C3a receptor activity;GO:0004930|G protein-coupled receptor activity;","K04009","C3AR1; C3a anaphylatoxin chemotactic receptor"]
["ENSRNOG00000020272",347,29.19493822,41,2.637547966,11.06896959,3.468449023,1.27E-77,{"v":1.42e-76,"d":"1.42E-76"},"up","yes","ENSRNOG00000020272","protein_coding","chr2:196091646-196168716:-","gi|568922649|ref|XP_006501474.1|",5237,0,"PREDICTED: UPF0577 protein KIAA1324 isoform X2 [Mus musculus]","gi|672043955|ref|XR_591282.1|",3350,0,"PREDICTED: Rattus norvegicus similar to KIAA1324 protein (RGD1310209), transcript variant X1, misc_RNA","A2AFS3",2006,0,"UPF0577 protein KIAA1324",".",".",".",".","pfam03302","VSP","Giardia variant-specific surface protein.","GO:0000045|autophagosome assembly;GO:0009267|cellular response to starvation;GO:0044090|positive regulation of vacuole organization;GO:2000786|positive regulation of autophagosome assembly;","GO:0005764|lysosome;GO:0005770|late endosome;GO:0005802|trans-Golgi network;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;",".",".","."]
["ENSRNOG00000018414",944,79.4236936,441,28.36972324,2.799593529,1.485217379,5.19E-77,{"v":5.79e-76,"d":"5.79E-76"},"up","yes","Csf1r","protein_coding","chr18:54546659-54590415:+","gi|564393690|ref|XP_006254875.1|",5059,0,"PREDICTED: macrophage colony-stimulating factor 1 receptor isoform X1 [Rattus norvegicus]","gi|672083476|ref|XM_008772148.1|",3845,0,"PREDICTED: Rattus norvegicus colony stimulating factor 1 receptor (Csf1r), transcript variant X3, mRNA","P09581",1738,0,"Macrophage colony-stimulating factor 1 receptor",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001934|positive regulation of protein phosphorylation;GO:0002244|hematopoietic progenitor cell differentiation;GO:0002931|response to ischemia;GO:0006954|inflammatory response;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007275|multicellular organism development;GO:0007411|axon guidance;GO:0007519|skeletal muscle tissue development;GO:0008283|cell proliferation;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0008360|regulation of cell shape;GO:0010759|positive regulation of macrophage chemotaxis;GO:0014005|microglia development;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0019221|cytokine-mediated signaling pathway;GO:0021542|dentate gyrus development;GO:0021772|olfactory bulb development;GO:0021879|forebrain neuron differentiation;GO:0030097|hemopoiesis;GO:0030316|osteoclast differentiation;GO:0030335|positive regulation of cell migration;GO:0031529|ruffle organization;GO:0032722|positive regulation of chemokine production;GO:0032944|regulation of mononuclear cell proliferation;GO:0033674|positive regulation of kinase activity;GO:0036006|cellular response to macrophage colony-stimulating factor stimulus;GO:0038145|macrophage colony-stimulating factor signaling pathway;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0043066|negative regulation of apoptotic process;GO:0044794|positive regulation by host of viral process;GO:0045087|innate immune response;GO:0045124|regulation of bone resorption;GO:0045217|cell-cell junction maintenance;GO:0045672|positive regulation of osteoclast differentiation;GO:0046488|phosphatidylinositol metabolic process;GO:0046777|protein autophosphorylation;GO:0048015|phosphatidylinositol-mediated signaling;GO:0061098|positive regulation of protein tyrosine kinase activity;GO:0061518|microglial cell proliferation;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071345|cellular response to cytokine stimulus;GO:0071902|positive regulation of protein serine/threonine kinase activity;GO:0120041|positive regulation of macrophage proliferation;GO:1990138|neuron projection extension;GO:2000147|positive regulation of cell motility;GO:2000249|regulation of actin cytoskeleton reorganization;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0043235|receptor complex;GO:1990682|CSF1-CSF1R complex;","GO:0003674|molecular_function;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0005011|macrophage colony-stimulating factor receptor activity;GO:0005524|ATP binding;GO:0019903|protein phosphatase binding;GO:0019955|cytokine binding;GO:0042803|protein homodimerization activity;","K05090","CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]"]
["ENSRNOG00000017869",776,65.28896847,316,20.32841847,3.211709193,1.683341269,{"v":5.96e-76,"d":"5.96E-76"},{"v":6.56e-75,"d":"6.56E-75"},"up","yes","Irf8","protein_coding","chr19:48790588-48811829:+","gi|56790291|ref|NP_001008722.1|",2280,0,"interferon regulatory factor 8 [Rattus norvegicus]","gi|672085188|ref|XM_006255737.2|",2278,0,"PREDICTED: Rattus norvegicus interferon regulatory factor 8 (Irf8), transcript variant X1, mRNA","P23611",849,0,"Interferon regulatory factor 8",".",".",".",".","pfam10401","IRF-3","Interferon-regulatory factor 3. This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1).  Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0002273|plasmacytoid dendritic cell differentiation;GO:0002314|germinal center B cell differentiation;GO:0002316|follicular B cell differentiation;GO:0002376|immune system process;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006909|phagocytosis;GO:0006955|immune response;GO:0009617|response to bacterium;GO:0030099|myeloid cell differentiation;GO:0032479|regulation of type I interferon production;GO:0032729|positive regulation of interferon-gamma production;GO:0032735|positive regulation of interleukin-12 production;GO:0042742|defense response to bacterium;GO:0042832|defense response to protozoan;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0060261|positive regulation of transcription initiation from RNA polymerase II promoter;GO:0071222|cellular response to lipopolysaccharide;GO:0071346|cellular response to interferon-gamma;GO:0097028|dendritic cell differentiation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0005515|protein binding;GO:1990837|sequence-specific double-stranded DNA binding;","K10155","IRF8; interferon regulatory factor 8"]
["ENSRNOG00000048053",361,30.37283198,51,3.280852347,9.257604051,3.21063886,1.03E-75,{"v":1.14e-74,"d":"1.14E-74"},"up","yes","AC128859.3","protein_coding","chr10:67953273-67983840:+","gi|293340296|ref|XP_002724574.1|",1817,0,"PREDICTED: schlafen family member 12 [Rattus norvegicus]","gi|49457868|gb|AC128859.4|",2216,0,"Rattus norvegicus 10 BAC CH230-436I22 (Children's Hospital Oakland Research Institute) complete sequence","Q8IYM2",321,{"v":8e-96,"d":"8.00E-96"},"Schlafen family member 12",".",".",".",".","pfam04326","AAA_4","Divergent AAA domain. This family is related to the pfam00004 family, and presumably has the same function (ATP-binding).",".",".",".",".","."]
["ENSRNOG00000061739",271,22.8006578,6,0.385982629,59.07172003,5.884395715,{"v":1.39e-75,"d":"1.39E-75"},{"v":1.53e-74,"d":"1.53E-74"},"up","yes","Klrk1","protein_coding","chr4:163081927-163092459:-","gi|564348312|ref|XP_006237135.1|",1238,{"v":5e-162,"d":"5.00E-162"},"PREDICTED: NKG2-D type II integral membrane protein isoform X2 [Rattus norvegicus]","gi|672051172|ref|XM_006237073.2|",2340,0,"PREDICTED: Rattus norvegicus killer cell lectin-like receptor subfamily K, member 1 (Klrk1), transcript variant X1, mRNA","O70215",450,{"v":1e-151,"d":"1.00E-151"},"NKG2-D type II integral membrane protein",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0002223|stimulatory C-type lectin receptor signaling pathway;GO:0002250|adaptive immune response;GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target;GO:0030101|natural killer cell activation;GO:0030154|cell differentiation;GO:0030887|positive regulation of myeloid dendritic cell activation;GO:0032729|positive regulation of interferon-gamma production;GO:0034260|negative regulation of GTPase activity;GO:0042267|natural killer cell mediated cytotoxicity;GO:0043065|positive regulation of apoptotic process;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;GO:0050830|defense response to Gram-positive bacterium;GO:0071222|cellular response to lipopolysaccharide;GO:2000502|negative regulation of natural killer cell chemotaxis;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0005515|protein binding;GO:0019900|kinase binding;GO:0030246|carbohydrate binding;GO:0032394|MHC class Ib receptor activity;GO:0038023|signaling receptor activity;GO:0042288|MHC class I protein binding;GO:0042802|identical protein binding;","K06728","KLRK1, CD314; killer cell lectin-like receptor subfamily K member 1"]
["ENSRNOG00000007178",337,28.35358553,41,2.637547966,10.74997911,3.426261951,{"v":1.02e-74,"d":"1.02E-74"},{"v":1.11e-73,"d":"1.11E-73"},"up","yes","Cd8a","protein_coding","chr4:103365804-103370040:+","gi|13928726|ref|NP_113726.1|",1047,{"v":4e-138,"d":"4.00E-138"},"T-cell surface glycoprotein CD8 alpha chain precursor [Rattus norvegicus]","gi|672049903|ref|XM_006236630.2|",1388,0,"PREDICTED: Rattus norvegicus CD8a molecule (Cd8a), transcript variant X2, mRNA","P07725",407,{"v":1E-139,"d":"1.00E-139"},"T-cell surface glycoprotein CD8 alpha chain",".",".",".",".","pfam00047","ig","Immunoglobulin domain. Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions. The Pfam alignments do not include the first and last strand of the immunoglobulin-like domain.","GO:0002456|T cell mediated immunity;GO:0006954|inflammatory response;GO:0007166|cell surface receptor signaling pathway;GO:0042110|T cell activation;GO:0045065|cytotoxic T cell differentiation;GO:0050850|positive regulation of calcium-mediated signaling;GO:0051607|defense response to virus;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0044853|plasma membrane raft;","GO:0019901|protein kinase binding;GO:0023024|MHC class I protein complex binding;GO:0042802|identical protein binding;","K06458","CD8A; T-cell surface glycoprotein CD8 alpha chain"]
["ENSRNOG00000007882",798,67.13994438,339,21.80801854,3.078681552,1.622312648,{"v":3.85e-74,"d":"3.85E-74"},{"v":4.15e-73,"d":"4.15E-73"},"up","yes","Ablim2","protein_coding","chr14:74866281-74990334:-","gi|568934146|ref|XP_006503980.1|",3153,0,"PREDICTED: actin-binding LIM protein 2 isoform X12 [Mus musculus]","gi|568934145|ref|XM_006503917.1|",2311,0,"PREDICTED: Mus musculus actin-binding LIM protein 2 (Ablim2), transcript variant X12, mRNA","Q6KC51",1040,0,"Actin-binding LIM protein 2",".",".",".",".","pfam02209","VHP","Villin headpiece domain.","GO:0006351|transcription, DNA-templated;GO:0030032|lamellipodium assembly;GO:0030036|actin cytoskeleton organization;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005737|cytoplasm;GO:0015629|actin cytoskeleton;GO:0030016|myofibril;","GO:0003779|actin binding;GO:0046872|metal ion binding;GO:0051015|actin filament binding;","K07520","ABLIM; actin-binding LIM protein"]
["ENSRNOG00000048088",1246,104.8325447,707,45.4816198,2.304943078,1.204731123,{"v":8.62e-74,"d":"8.62E-74"},{"v":9.28e-73,"d":"9.28E-73"},"up","yes","Mest","protein_coding","chr4:59354447-59366145:+","gi|57528148|ref|NP_001009617.1|",1712,0,"mesoderm-specific transcript homolog protein [Rattus norvegicus]","gi|356582505|ref|NM_008590.2|",1821,0,"Mus musculus mesoderm specific transcript (Mest), transcript variant 2, mRNA","Q6P5P5",664,0,"Mesoderm-specific transcript homolog protein",".",".",".",".","pfam12697","Abhydrolase_6","Alpha/beta hydrolase family. This family contains alpha/beta hydrolase enzymes of diverse specificity.","GO:0010883|regulation of lipid storage;GO:0032526|response to retinoic acid;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0016787|hydrolase activity;",".","."]
["ENSRNOG00000029195",662,55.69754784,241,15.5036356,3.592547533,1.845007245,{"v":1.18e-73,"d":"1.18E-73"},{"v":1.27e-72,"d":"1.27E-72"},"up","yes","Uba7","protein_coding","chr8:108665292-108674099:+","gi|564365408|ref|XP_006243803.1|",5231,0,"PREDICTED: ubiquitin-like modifier-activating enzyme 7 isoform X1 [Rattus norvegicus]","gi|672062911|ref|XM_006243741.2|",3163,0,"PREDICTED: Rattus norvegicus ubiquitin-like modifier activating enzyme 7 (Uba7), transcript variant X1, mRNA","P41226",1400,0,"Ubiquitin-like modifier-activating enzyme 7","YKL210w",700,0,"COG0476","pfam00899","ThiF","ThiF family. This family contains a repeated domain in ubiquitin activating enzyme E1 and members of the bacterial ThiF/MoeB/HesA family.","GO:0006464|cellular protein modification process;GO:0006974|cellular response to DNA damage stimulus;GO:0016567|protein ubiquitination;GO:0019941|modification-dependent protein catabolic process;GO:0032020|ISG15-protein conjugation;GO:0032446|protein modification by small protein conjugation;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0004839|ubiquitin activating enzyme activity;GO:0004842|ubiquitin-protein transferase activity;GO:0005524|ATP binding;GO:0019782|ISG15 activating enzyme activity;","K10698","UBE1L, UBA7; ubiquitin-activating enzyme E1-like [EC:6.2.1.45]"]
["ENSRNOG00000037409",327,27.51223285,38,2.444556651,11.25448774,3.492428487,1.19E-73,{"v":1.28e-72,"d":"1.28E-72"},"up","yes","Scimp","protein_coding","chr10:55507519-55528171:-","gi|293351630|ref|XP_001080739.2|",669,{"v":3e-82,"d":"3.00E-82"},"PREDICTED: SLP adapter and CSK-interacting membrane protein isoform X2 [Rattus norvegicus]","gi|672024902|ref|XM_003752341.3|",1057,0,"PREDICTED: Rattus norvegicus SLP adaptor and CSK interacting membrane protein (Scimp), transcript variant X1, mRNA","Q3UU41",220,{"v":2e-67,"d":"2.00E-67"},"SLP adapter and CSK-interacting membrane protein",".",".",".",".","pfam15050","SCIMP","SCIMP protein. This family contains the SCIMP proteins which are a a transmembrane adaptor protein involved in major histocompatibility complex class II signaling.","GO:0002720|positive regulation of cytokine production involved in immune response;GO:0002732|positive regulation of dendritic cell cytokine production;GO:0031666|positive regulation of lipopolysaccharide-mediated signaling pathway;GO:0032735|positive regulation of interleukin-12 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032874|positive regulation of stress-activated MAPK cascade;GO:0034138|toll-like receptor 3 signaling pathway;GO:0034142|toll-like receptor 4 signaling pathway;GO:0034154|toll-like receptor 7 signaling pathway;GO:0038123|toll-like receptor TLR1:TLR2 signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071226|cellular response to molecule of fungal origin;","GO:0001726|ruffle;GO:0001772|immunological synapse;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030175|filopodium;GO:0031256|leading edge membrane;GO:0031259|uropod membrane;GO:0043235|receptor complex;GO:0045335|phagocytic vesicle;GO:0097197|tetraspanin-enriched microdomain;","GO:0060090|molecular adaptor activity;",".","."]
["ENSRNOG00000027008",823,69.2433261,361,23.22328818,2.981633158,1.576102768,2.35E-73,{"v":2.51e-72,"d":"2.51E-72"},"up","yes","Igtp","protein_coding","chr10:42357400-42408247:+","gi|32527749|gb|AAP86276.1|",6541,0,"Ac2-233 [Rattus norvegicus]","gi|32527748|gb|AY321344.1|",2775,0,"Rattus norvegicus Ac2-233 mRNA, complete cds","Q3T9E4",397,{"v":3e-123,"d":"3.00E-123"},"T-cell-specific guanine nucleotide triphosphate-binding protein 2",".",".",".",".","pfam05049","IIGP","Interferon-inducible GTPase (IIGP). Interferon-inducible GTPase (IIGP) is thought to play a role in in intracellular defence. IIGP is predominantly associated with the Golgi apparatus and also localizes to the endoplasmic reticulum and exerts a distinct role in IFN-induced intracellular membrane trafficking or processing.","GO:0006952|defense response;GO:0035458|cellular response to interferon-beta;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0003924|GTPase activity;GO:0005525|GTP binding;","K14140","IGTP; interferon gamma induced GTPase"]
["ENSRNOG00000042905",429,36.09403025,92,5.918400313,6.09861252,2.608481056,{"v":3.11e-73,"d":"3.11E-73"},{"v":3.31e-72,"d":"3.31E-72"},"up","yes","RT1-T24-4","protein_coding","chr20:2684515-2692511:+","gi|77404170|ref|NP_001008826.2|",1830,0,"RT1 class I, locus T24, gene 4 [Rattus norvegicus]","gi|261862313|ref|NM_001008826.3|",1650,0,"Rattus norvegicus RT1 class I, locus T24, gene 4 (RT1-T24-4), mRNA","P16391",383,{"v":5e-127,"d":"5.00E-127"},"RT1 class I histocompatibility antigen, AA alpha chain",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.","GO:0001916|positive regulation of T cell mediated cytotoxicity;GO:0002476|antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002486|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0006955|immune response;","GO:0005615|extracellular space;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0005102|signaling receptor binding;GO:0042605|peptide antigen binding;","K06751","MHC1; MHC class I antigen"]
["ENSRNOG00000046834",441,37.10365347,99,6.36871338,5.825926095,2.5424874,{"v":3.54e-73,"d":"3.54E-73"},{"v":3.75e-72,"d":"3.75E-72"},"up","yes","C3","protein_coding","chr9:2087437-2114429:-","gi|158138561|ref|NP_058690.2|",7781,0,"complement C3 precursor [Rattus norvegicus]","gi|158138560|ref|NM_016994.2|",4433,0,"Rattus norvegicus complement component 3 (C3), mRNA","P01026",2956,0,"Complement C3",".",".",".",".","pfam07678","A2M_comp","A-macroglobulin complement component. This family includes the complement components region of the alpha-2-macroglobulin family.","GO:0001798|positive regulation of type IIa hypersensitivity;GO:0001934|positive regulation of protein phosphorylation;GO:0001970|positive regulation of activation of membrane attack complex;GO:0002507|tolerance induction;GO:0006631|fatty acid metabolic process;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0006956|complement activation;GO:0006957|complement activation, alternative pathway;GO:0006958|complement activation, classical pathway;GO:0007596|blood coagulation;GO:0009617|response to bacterium;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0010828|positive regulation of glucose transmembrane transport;GO:0010866|regulation of triglyceride biosynthetic process;GO:0010884|positive regulation of lipid storage;GO:0010951|negative regulation of endopeptidase activity;GO:0016322|neuron remodeling;GO:0032026|response to magnesium ion;GO:0032355|response to estradiol;GO:0032570|response to progesterone;GO:0035846|oviduct epithelium development;GO:0035886|vascular smooth muscle cell differentiation;GO:0043627|response to estrogen;GO:0045087|innate immune response;GO:0045745|positive regulation of G protein-coupled receptor signaling pathway;GO:0045766|positive regulation of angiogenesis;GO:0048260|positive regulation of receptor-mediated endocytosis;GO:0048639|positive regulation of developmental growth;GO:0050766|positive regulation of phagocytosis;GO:0051384|response to glucocorticoid;GO:0060041|retina development in camera-type eye;GO:0060100|positive regulation of phagocytosis, engulfment;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0097242|amyloid-beta clearance;GO:0097278|complement-dependent cytotoxicity;GO:0150062|complement-mediated synapse pruning;GO:0150064|vertebrate eye-specific patterning;GO:1901555|response to paclitaxel;GO:1905114|cell surface receptor signaling pathway involved in cell-cell signaling;GO:2000427|positive regulation of apoptotic cell clearance;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0009986|cell surface;GO:0032991|protein-containing complex;","GO:0004866|endopeptidase inhibitor activity;GO:0005515|protein binding;GO:0008289|lipid binding;GO:0031715|C5L2 anaphylatoxin chemotactic receptor binding;","K03990","C3; complement component 3"]
["ENSRNOG00000013783",1375,115.6859944,825,53.0726115,2.179768267,1.124174769,{"v":6.19e-73,"d":"6.19E-73"},{"v":6.54e-72,"d":"6.54E-72"},"up","yes","Efhd2","protein_coding","chr5:154160946-154176980:-","gi|72255531|ref|NP_001026818.1|",936,{"v":3e-118,"d":"3.00E-118"},"EF-hand domain-containing protein D2 [Rattus norvegicus]","gi|72255530|ref|NM_001031648.1|",2107,0,"Rattus norvegicus EF-hand domain family, member D2 (Efhd2), mRNA","Q4FZY0",365,{"v":1E-119,"d":"1.00E-119"},"EF-hand domain-containing protein D2",".",".",".",".","pfam13499","EF-hand_7","EF-hand domain pair.",".","GO:0045121|membrane raft;","GO:0005509|calcium ion binding;","K23922","EFHD2; EF-hand domain-containing family member D2"]
["ENSRNOG00000006094",556,46.77920937,171,11.00050493,4.252460198,2.088297733,{"v":7.33e-73,"d":"7.33E-73"},{"v":7.73e-72,"d":"7.73E-72"},"up","yes","Cd44","protein_coding","chr3:89157058-89244620:-","gi|149022754|gb|EDL79648.1|",3838,0,"CD44 antigen, isoform CRA_a [Rattus norvegicus]","gi|672046391|ref|XM_008762059.1|",3940,0,"PREDICTED: Rattus norvegicus Cd44 molecule (Cd44), transcript variant X8, mRNA","P15379",1312,0,"CD44 antigen",".",".",".",".","pfam00193","Xlink","Extracellular link domain.","GO:0001558|regulation of cell growth;GO:0001658|branching involved in ureteric bud morphogenesis;GO:0001955|blood vessel maturation;GO:0002246|wound healing involved in inflammatory response;GO:0002906|negative regulation of mature B cell apoptotic process;GO:0006954|inflammatory response;GO:0007155|cell adhesion;GO:0010628|positive regulation of gene expression;GO:0014070|response to organic cyclic compound;GO:0016055|Wnt signaling pathway;GO:0016477|cell migration;GO:0019221|cytokine-mediated signaling pathway;GO:0030214|hyaluronan catabolic process;GO:0031175|neuron projection development;GO:0031667|response to nutrient levels;GO:0033031|positive regulation of neutrophil apoptotic process;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0033189|response to vitamin A;GO:0033674|positive regulation of kinase activity;GO:0034116|positive regulation of heterotypic cell-cell adhesion;GO:0034238|macrophage fusion;GO:0042110|T cell activation;GO:0043066|negative regulation of apoptotic process;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043518|negative regulation of DNA damage response, signal transduction by p53 class mediator;GO:0044319|wound healing, spreading of cells;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0045590|negative regulation of regulatory T cell differentiation;GO:0050728|negative regulation of inflammatory response;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0051216|cartilage development;GO:0060442|branching involved in prostate gland morphogenesis;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070487|monocyte aggregation;GO:1900625|positive regulation of monocyte aggregation;GO:1902166|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:2000392|regulation of lamellipodium morphogenesis;GO:2000562|negative regulation of CD4-positive, alpha-beta T cell proliferation;","GO:0005634|nucleus;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005902|microvillus;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0031258|lamellipodium membrane;GO:0032991|protein-containing complex;GO:0035692|macrophage migration inhibitory factor receptor complex;GO:0042995|cell projection;","GO:0004888|transmembrane signaling receptor activity;GO:0004896|cytokine receptor activity;GO:0005114|type II transforming growth factor beta receptor binding;GO:0005154|epidermal growth factor receptor binding;GO:0005515|protein binding;GO:0005540|hyaluronic acid binding;GO:0019901|protein kinase binding;GO:0019955|cytokine binding;GO:0051219|phosphoprotein binding;","K06256","CD44; CD44 antigen"]
["ENSRNOG00000005620",466,39.20703519,115,7.398000391,5.299680064,2.405905268,{"v":1.3E-72,"d":"1.30E-72"},1.37E-71,"up","yes","Lcp2","protein_coding","chr10:18642658-18689559:+","gi|18426850|ref|NP_569105.1|",2156,0,"lymphocyte cytosolic protein 2 [Rattus norvegicus]","gi|71896578|ref|NM_130421.2|",3361,0,"Rattus norvegicus lymphocyte cytosolic protein 2 (Lcp2), mRNA","Q60787",751,0,"Lymphocyte cytosolic protein 2",".",".",".",".","pfam00017","SH2","SH2 domain.","GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0035556|intracellular signal transduction;GO:0045576|mast cell activation;GO:0045860|positive regulation of protein kinase activity;GO:0050852|T cell receptor signaling pathway;","GO:0005829|cytosol;GO:0005911|cell-cell junction;GO:0036398|TCR signalosome;GO:0044853|plasma membrane raft;",".","K07361","LCP2; lymphocyte cytosolic protein 2"]
["ENSRNOG00000003895",574,48.2936442,185,11.90113106,4.057903736,2.020734641,{"v":4.04e-72,"d":"4.04E-72"},{"v":4.23e-71,"d":"4.23E-71"},"up","yes","Rgs1","protein_coding","chr13:56018554-56022984:-","gi|564381005|ref|XP_006250036.1|",1116,{"v":3e-149,"d":"3.00E-149"},"PREDICTED: regulator of G-protein signaling 1 isoform X1 [Rattus norvegicus]","gi|672074140|ref|XM_006249974.2|",1350,0,"PREDICTED: Rattus norvegicus regulator of G-protein signaling 1 (Rgs1), transcript variant X1, mRNA","P97844",434,{"v":1E-150,"d":"1.00E-150"},"Regulator of G-protein signaling 1",".",".",".",".","pfam00615","RGS","Regulator of G protein signaling domain. RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.","GO:0007165|signal transduction;GO:0007186|G protein-coupled receptor signaling pathway;GO:0008277|regulation of G protein-coupled receptor signaling pathway;GO:0009617|response to bacterium;GO:0009968|negative regulation of signal transduction;GO:0043547|positive regulation of GTPase activity;GO:0061737|leukotriene signaling pathway;","GO:0005829|cytosol;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;","GO:0001965|G-protein alpha-subunit binding;GO:0005096|GTPase activator activity;","K16449","RGS; regulator of G-protein signaling"]
["ENSRNOG00000012172",501,42.15176959,140,9.006261346,4.680273864,2.226592951,{"v":3.45e-71,"d":"3.45E-71"},{"v":3.55e-70,"d":"3.55E-70"},"up","yes","Spi1","protein_coding","chr3:77073012-77092393:+","gi|564341813|ref|XP_006234594.1|",1276,{"v":4e-169,"d":"4.00E-169"},"PREDICTED: transcription factor PU.1 isoform X1 [Rattus norvegicus]","gi|672046223|ref|XM_006234532.2|",2027,0,"PREDICTED: Rattus norvegicus Spi-1 proto-oncogene (Spi1), transcript variant X1, mRNA","Q6BDS1",489,{"v":5E-168,"d":"5.00E-168"},"Transcription factor PU.1",".",".",".",".","pfam00178","Ets","Ets-domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001944|vasculature development;GO:0002314|germinal center B cell differentiation;GO:0002316|follicular B cell differentiation;GO:0002320|lymphoid progenitor cell differentiation;GO:0002327|immature B cell differentiation;GO:0002357|defense response to tumor cell;GO:0002572|pro-T cell differentiation;GO:0002573|myeloid leukocyte differentiation;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0030098|lymphocyte differentiation;GO:0030154|cell differentiation;GO:0030218|erythrocyte differentiation;GO:0030225|macrophage differentiation;GO:0030851|granulocyte differentiation;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0035019|somatic stem cell population maintenance;GO:0036462|TRAIL-activated apoptotic signaling pathway;GO:0043011|myeloid dendritic cell differentiation;GO:0043314|negative regulation of neutrophil degranulation;GO:0043966|histone H3 acetylation;GO:0044027|hypermethylation of CpG island;GO:0045347|negative regulation of MHC class II biosynthetic process;GO:0045646|regulation of erythrocyte differentiation;GO:0045814|negative regulation of gene expression, epigenetic;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051090|regulation of DNA-binding transcription factor activity;GO:0060033|anatomical structure regression;GO:0070102|interleukin-6-mediated signaling pathway;GO:0071361|cellular response to ethanol;GO:0090241|negative regulation of histone H4 acetylation;GO:0090402|oncogene-induced cell senescence;GO:0098508|endothelial to hematopoietic transition;GO:0120186|negative regulation of protein localization to chromatin;GO:1900745|positive regulation of p38MAPK cascade;GO:1901223|negative regulation of NIK/NF-kappaB signaling;GO:1901674|regulation of histone H3-K27 acetylation;GO:1902262|apoptotic process involved in blood vessel morphogenesis;GO:1902895|positive regulation of pri-miRNA transcription by RNA polymerase II;GO:1904151|positive regulation of microglial cell mediated cytotoxicity;GO:1904178|negative regulation of adipose tissue development;GO:1904238|pericyte cell differentiation;GO:1905036|positive regulation of antifungal innate immune response;GO:1905453|regulation of myeloid progenitor cell differentiation;GO:2000529|positive regulation of myeloid dendritic cell chemotaxis;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987|proximal promoter sequence-specific DNA binding;GO:0001216|bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding;GO:0001217|bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003700|DNA-binding transcription factor activity;GO:0005515|protein binding;GO:0042826|histone deacetylase binding;GO:0043565|sequence-specific DNA binding;GO:0051525|NFAT protein binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;GO:0097677|STAT family protein binding;","K09438","SPI1; transcription factor PU.1"]
["ENSRNOG00000022975",393,33.06516058,77,4.95344374,6.675186459,2.738808136,{"v":9.3e-71,"d":"9.30E-71"},{"v":9.53e-70,"d":"9.53E-70"},"up","yes","Nfam1","protein_coding","chr7:114139345-114175442:-","gi|564309086|ref|XP_006226237.1|",1205,{"v":4e-155,"d":"4.00E-155"},"PREDICTED: NFAT activation molecule 1 isoform X1 [Rattus norvegicus]","gi|672022166|ref|XM_006226175.2|",2841,0,"PREDICTED: Rattus norvegicus NFAT activating protein with ITAM motif 1 (Nfam1), transcript variant X1, mRNA","Q8R4V1",284,{"v":1e-86,"d":"1.00E-86"},"NFAT activation molecule 1",".",".",".",".","pfam15068","FAM101","FAM101 family. This protein family includes the actin regulators, Refilin A and B, however the exact function of this protein family remains unknown. Refilin is thought to stabilize peri-nuclear actin filament bundles, important in fibroblasts. Refilin is important as changes in localisation and shape in the nucleus plays a role in cellular and developmental processes.","GO:0001819|positive regulation of cytokine production;GO:0007165|signal transduction;GO:0030183|B cell differentiation;GO:0035556|intracellular signal transduction;GO:0045577|regulation of B cell differentiation;GO:0050853|B cell receptor signaling pathway;GO:0050861|positive regulation of B cell receptor signaling pathway;GO:0051091|positive regulation of DNA-binding transcription factor activity;","GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0045121|membrane raft;","GO:0004888|transmembrane signaling receptor activity;",".","."]
["ENSRNOG00000001369",805,67.72889126,359,23.09462731,2.932668727,1.552214114,{"v":2.98e-70,"d":"2.98E-70"},3.03E-69,"up","yes","Oas1a","protein_coding","chr12:35669801-35680517:+","gi|149063436|gb|EDM13759.1|",1750,0,"rCG21913 [Rattus norvegicus]","gi|672072909|ref|XM_006249382.2|",1125,0,"PREDICTED: Rattus norvegicus 2'-5' oligoadenylate synthetase 1A (Oas1a), transcript variant X1, mRNA","Q05961",677,0,"2'-5'-oligoadenylate synthase 1A",".",".",".",".","pfam10421","OAS1_C","2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus. This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between 320 and 344 at the extreme C-terminal end. Oligoadenylate synthetases are antiviral enzymes that counteract vial attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesize 2'.5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication. This domain is often associated with NTP_transf_2 pfam01909.","GO:0006006|glucose metabolic process;GO:0006164|purine nucleotide biosynthetic process;GO:0009615|response to virus;GO:0032728|positive regulation of interferon-beta production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0034138|toll-like receptor 3 signaling pathway;GO:0034142|toll-like receptor 4 signaling pathway;GO:0035457|cellular response to interferon-alpha;GO:0035458|cellular response to interferon-beta;GO:0042593|glucose homeostasis;GO:0042742|defense response to bacterium;GO:0043129|surfactant homeostasis;GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0051259|protein complex oligomerization;GO:0051607|defense response to virus;GO:0060337|type I interferon signaling pathway;GO:0060339|negative regulation of type I interferon-mediated signaling pathway;GO:0060700|regulation of ribonuclease activity;GO:0070106|interleukin-27-mediated signaling pathway;GO:0071639|positive regulation of monocyte chemotactic protein-1 production;GO:0071659|negative regulation of IP-10 production;GO:0098586|cellular response to virus;GO:1901857|positive regulation of cellular respiration;GO:2000342|negative regulation of chemokine (C-X-C motif) ligand 2 production;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;GO:0005840|ribosome;GO:0016020|membrane;","GO:0001730|2'-5'-oligoadenylate synthetase activity;GO:0003725|double-stranded RNA binding;GO:0005524|ATP binding;GO:0046872|metal ion binding;","K14216","OAS; 2'-5'-oligoadenylate synthetase [EC:2.7.7.84]"]
["ENSRNOG00000000795",917,77.15204135,448,28.82003631,2.677027903,1.420632176,{"v":3.65e-70,"d":"3.65E-70"},{"v":3.7e-69,"d":"3.70E-69"},"up","yes","RT1-N3","protein_coding","chr20:2661584-2665530:+","gi|57012390|ref|NP_001008855.1|",1798,0,"RT1 class Ib, locus N3 [Rattus norvegicus]","gi|261878534|ref|NM_001008855.2|",1450,0,"Rattus norvegicus RT1 class Ib, locus N3 (RT1-N3), mRNA","P01897",331,{"v":7E-105,"d":"7.00E-105"},"H-2 class I histocompatibility antigen, L-D alpha chain",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.","GO:0001916|positive regulation of T cell mediated cytotoxicity;GO:0002476|antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002486|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0006955|immune response;","GO:0005615|extracellular space;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0005102|signaling receptor binding;GO:0042605|peptide antigen binding;","K06751","MHC1; MHC class I antigen"]
["ENSRNOG00000012965",314,26.41847435,39,2.508887089,10.52995747,3.396427705,{"v":2.9e-69,"d":"2.90E-69"},2.92E-68,"up","yes","Themis2","protein_coding","chr5:144991112-145006400:-","gi|407228396|ref|NP_001258409.1|",3198,0,"protein THEMIS2 [Rattus norvegicus]","gi|407228395|ref|NM_001271480.1|",1974,0,"Rattus norvegicus thymocyte selection associated family member 2 (Themis2), mRNA","Q91YX0",1058,0,"Protein THEMIS2",".",".",".",".","pfam12736","CABIT","Cell-cycle sustaining, positive selection,. The 'CABIT' domain (for 'cysteine-containing, all- in Themis') is found in a newly identified gene family that has three mammalian homologues (Themis, Icb1 and 9130404H23Rik) that encode proteins with two CABIT domains and a highly conserved proline-rich region. In contrast, Fam59A, Fam59B and related proteins from mammals to cnidarians, including the insect Serrano proteins, have a single copy of the CABIT domain, a proline-rich region and often a C-terminal SAM (sterile-motif) domain. Multiple-sequence alignment has predicted that the CABIT domain adopts an all-strand structure with at least 12 strands, ie a dyad of six-stranded beta-barrel units. The CABIT domain contains a nearly absolutely conserved cysteine residue which is likely to be central to its function. CABIT domain proteins function downstream of tyrosine kinase signalling and interact with GRB2.","GO:0050852|T cell receptor signaling pathway;GO:0050864|regulation of B cell activation;","GO:0005634|nucleus;GO:0005737|cytoplasm;",".",".","."]
["ENSRNOG00000024689",636,53.51003086,240,15.43930516,3.465831544,1.793201534,{"v":3.4e-68,"d":"3.40E-68"},{"v":3.39e-67,"d":"3.39E-67"},"up","yes","Hopx","protein_coding","chr14:31075148-31082909:+","gi|149035176|gb|EDL89880.1|",410,{"v":6e-46,"d":"6.00E-46"},"homeobox only domain, isoform CRA_a [Rattus norvegicus]","gi|298914492|emb|FQ229504.1|",798,0,"Rattus norvegicus TL0ADA47YK21 mRNA sequence","Q78ZR5",102,{"v":3E-32,"d":"3.00E-32"},"Homeodomain-only protein",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001829|trophectodermal cell differentiation;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007507|heart development;GO:0008016|regulation of heart contraction;GO:0016575|histone deacetylation;GO:0043393|regulation of protein binding;GO:0043415|positive regulation of skeletal muscle tissue regeneration;GO:0045596|negative regulation of cell differentiation;GO:0048286|lung alveolus development;GO:0051131|chaperone-mediated protein complex assembly;GO:0051155|positive regulation of striated muscle cell differentiation;","GO:0005634|nucleus;",".","K24897","HOPX; homeodomain-only protein"]
["ENSRNOG00000004649",476,40.04838788,132,8.49161784,4.716225886,2.237632819,{"v":3.96e-68,"d":"3.96E-68"},{"v":3.92e-67,"d":"3.92E-67"},"up","yes","Il1b","protein_coding","chr3:116577010-116583415:-","gi|158186736|ref|NP_113700.2|",1243,{"v":6e-165,"d":"6.00E-165"},"interleukin-1 beta precursor [Rattus norvegicus]","gi|158186735|ref|NM_031512.2|",1209,0,"Rattus norvegicus interleukin 1 beta (Il1b), mRNA","Q63264",479,{"v":4E-165,"d":"4.00E-165"},"Interleukin-1 beta",".",".",".",".","pfam00340","IL1","Interleukin-1 / 18. This family includes interleukin-1 and interleukin-18.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0000165|MAPK cascade;GO:0001660|fever generation;GO:0001666|response to hypoxia;GO:0001934|positive regulation of protein phosphorylation;GO:0002439|chronic inflammatory response to antigenic stimulus;GO:0002526|acute inflammatory response;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007584|response to nutrient;GO:0007611|learning or memory;GO:0007613|memory;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0009408|response to heat;GO:0009410|response to xenobiotic stimulus;GO:0009743|response to carbohydrate;GO:0010193|response to ozone;GO:0010243|response to organonitrogen compound;GO:0010332|response to gamma radiation;GO:0010573|vascular endothelial growth factor production;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010718|positive regulation of epithelial to mesenchymal transition;GO:0010829|negative regulation of glucose transmembrane transport;GO:0010942|positive regulation of cell death;GO:0014050|negative regulation of glutamate secretion;GO:0014070|response to organic cyclic compound;GO:0019221|cytokine-mediated signaling pathway;GO:0030213|hyaluronan biosynthetic process;GO:0030335|positive regulation of cell migration;GO:0030593|neutrophil chemotaxis;GO:0030728|ovulation;GO:0030730|sequestering of triglyceride;GO:0031394|positive regulation of prostaglandin biosynthetic process;GO:0031622|positive regulation of fever generation;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0032308|positive regulation of prostaglandin secretion;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0032722|positive regulation of chemokine production;GO:0032725|positive regulation of granulocyte macrophage colony-stimulating factor production;GO:0032729|positive regulation of interferon-gamma production;GO:0032743|positive regulation of interleukin-2 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0032874|positive regulation of stress-activated MAPK cascade;GO:0033092|positive regulation of immature T cell proliferation in thymus;GO:0033198|response to ATP;GO:0033280|response to vitamin D;GO:0033591|response to L-ascorbic acid;GO:0034116|positive regulation of heterotypic cell-cell adhesion;GO:0035176|social behavior;GO:0035234|ectopic germ cell programmed cell death;GO:0035505|positive regulation of myosin light chain kinase activity;GO:0035634|response to stilbenoid;GO:0035902|response to immobilization stress;GO:0042060|wound healing;GO:0042102|positive regulation of T cell proliferation;GO:0043065|positive regulation of apoptotic process;GO:0043122|regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043278|response to morphine;GO:0043406|positive regulation of MAP kinase activity;GO:0043407|negative regulation of MAP kinase activity;GO:0043434|response to peptide hormone;GO:0043491|protein kinase B signaling;GO:0043507|positive regulation of JUN kinase activity;GO:0043525|positive regulation of neuron apoptotic process;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0045471|response to ethanol;GO:0045665|negative regulation of neuron differentiation;GO:0045687|positive regulation of glial cell differentiation;GO:0045766|positive regulation of angiogenesis;GO:0045833|negative regulation of lipid metabolic process;GO:0045840|positive regulation of mitotic nuclear division;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045917|positive regulation of complement activation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046330|positive regulation of JNK cascade;GO:0046627|negative regulation of insulin receptor signaling pathway;GO:0048143|astrocyte activation;GO:0048711|positive regulation of astrocyte differentiation;GO:0050691|regulation of defense response to virus by host;GO:0050729|positive regulation of inflammatory response;GO:0050766|positive regulation of phagocytosis;GO:0050767|regulation of neurogenesis;GO:0050768|negative regulation of neurogenesis;GO:0050796|regulation of insulin secretion;GO:0050805|negative regulation of synaptic transmission;GO:0050900|leukocyte migration;GO:0050995|negative regulation of lipid catabolic process;GO:0050996|positive regulation of lipid catabolic process;GO:0050999|regulation of nitric-oxide synthase activity;GO:0051044|positive regulation of membrane protein ectodomain proteolysis;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051384|response to glucocorticoid;GO:0051781|positive regulation of cell division;GO:0060252|positive regulation of glial cell proliferation;GO:0060559|positive regulation of calcidiol 1-monooxygenase activity;GO:0070164|negative regulation of adiponectin secretion;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070487|monocyte aggregation;GO:0070498|interleukin-1-mediated signaling pathway;GO:0070555|response to interleukin-1;GO:0071222|cellular response to lipopolysaccharide;GO:0071236|cellular response to antibiotic;GO:0071260|cellular response to mechanical stimulus;GO:0071310|cellular response to organic substance;GO:0071333|cellular response to glucose stimulus;GO:0071396|cellular response to lipid;GO:0071398|cellular response to fatty acid;GO:0071407|cellular response to organic cyclic compound;GO:0071466|cellular response to xenobiotic stimulus;GO:0071548|response to dexamethasone;GO:0071639|positive regulation of monocyte chemotactic protein-1 production;GO:0090023|positive regulation of neutrophil chemotaxis;GO:0097192|extrinsic apoptotic signaling pathway in absence of ligand;GO:1900745|positive regulation of p38MAPK cascade;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1902680|positive regulation of RNA biosynthetic process;GO:1903140|regulation of establishment of endothelial barrier;GO:1903597|negative regulation of gap junction assembly;GO:2000173|negative regulation of branching morphogenesis of a nerve;GO:2000178|negative regulation of neural precursor cell proliferation;GO:2000556|positive regulation of T-helper 1 cell cytokine production;GO:2001240|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005764|lysosome;GO:0005829|cytosol;GO:0030141|secretory granule;GO:0031982|vesicle;","GO:0005125|cytokine activity;GO:0005149|interleukin-1 receptor binding;GO:0005178|integrin binding;GO:0019904|protein domain specific binding;","K04519","IL1B; interleukin 1 beta"]
["ENSRNOG00000034139",399,33.56997219,86,5.532417684,6.067866547,2.601189356,{"v":4.87e-68,"d":"4.87E-68"},{"v":4.81e-67,"d":"4.81E-67"},"up","yes","Lyc2","protein_coding","chr7:52886883-52894446:+","gi|190360687|ref|NP_001121966.1|",492,{"v":6e-55,"d":"6.00E-55"},"putative lysozyme C-2 precursor [Rattus norvegicus]","gi|294584|gb|L12458.1|RATLYSZYM",907,0,"Rat lysozyme gene, complete cds","Q05820",191,{"v":1e-55,"d":"1.00E-55"},"Putative lysozyme C-2",".",".",".",".","pfam00062","Lys","C-type lysozyme/alpha-lactalbumin family. Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.","GO:0019835|cytolysis;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;","GO:0005576|extracellular region;","GO:0003796|lysozyme activity;","K13915","LYZ; lysozyme C [EC:3.2.1.17]"]
["ENSRNOG00000021380",1153,97.00796475,657,42.26509789,2.295226312,1.198636412,{"v":6.87e-68,"d":"6.87E-68"},{"v":6.76e-67,"d":"6.76E-67"},"up","yes","Fads6","protein_coding","chr10:100522981-100538181:-","gi|157818323|ref|NP_001100534.1|",1622,0,"fatty acid desaturase 6 [Rattus norvegicus]","gi|157818322|ref|NM_001107064.1|",1796,0,"Rattus norvegicus fatty acid desaturase 6 (Fads6), mRNA","Q80UG1",590,0,"Fatty acid desaturase 6",".",".",".",".","pfam00487","FA_desaturase","Fatty acid desaturase.","GO:0006629|lipid metabolic process;","GO:0016021|integral component of membrane;","GO:0016717|oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water;","K12419","FADS6; fatty acid desaturase 6 [EC:1.14.19.-]"]
["ENSRNOG00000006723",473,39.79598207,131,8.427287402,4.722276596,2.239482547,{"v":8.88e-68,"d":"8.88E-68"},{"v":8.71e-67,"d":"8.71E-67"},"up","yes","Itga11","protein_coding","chr8:63146001-63254407:+","gi|672062052|ref|XP_008764500.1|",6362,0,"PREDICTED: integrin alpha-11 isoform X2 [Rattus norvegicus]","gi|672062051|ref|XM_008766278.1|",4913,0,"PREDICTED: Rattus norvegicus integrin, alpha 11 (Itga11), transcript variant X2, mRNA","P61622",2385,0,"Integrin alpha-11",".",".",".",".","pfam08441","Integrin_alpha2","Integrin alpha. This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.","GO:0006929|substrate-dependent cell migration;GO:0007160|cell-matrix adhesion;GO:0007229|integrin-mediated signaling pathway;GO:0008150|biological_process;GO:0033627|cell adhesion mediated by integrin;GO:0038065|collagen-activated signaling pathway;","GO:0005575|cellular_component;GO:0005925|focal adhesion;GO:0034681|integrin alpha11-beta1 complex;","GO:0003674|molecular_function;GO:0005518|collagen binding;GO:0038064|collagen receptor activity;GO:0046872|metal ion binding;GO:0098639|collagen binding involved in cell-matrix adhesion;","K06587","ITGA11; integrin alpha 11"]
["ENSRNOG00000064743",286,24.06268683,1,0.064330438,374.0482346,8.547080512,{"v":4.32e-67,"d":"4.32E-67"},{"v":4.18e-66,"d":"4.18E-66"},"up","yes","ENSRNOG00000064743","rRNA","chr3:2235683-2240483:+","gi|954470796|gb|KRZ01443.1|",894,{"v":4e-105,"d":"4.00E-105"},"hypothetical protein T11_16386 [Trichinella zimbabwensis]","gi|374429576|ref|NR_046246.1|",4681,0,"Rattus norvegicus 28S ribosomal RNA (Rn28s), ribosomal RNA","P47226",70.5,{"v":5e-11,"d":"5.00E-11"},"Testin",".",".",".",".","pfam15498","Dendrin","Nephrin and CD2AP-binding protein, Dendrin. Dendrin is a family of eukaryotic proteins found in the podocytes of the kidneys. Dendrin, originally identified in telencephalic dendrites, is a constituent of the slit diaphragm, SD, complex of podocytes, where it directly binds to nephrin and CD2AP. Kidney podocytes and their slit diaphragms (SDs) form the final barrier to urinary protein loss. SD proteins also participate in intracellular signalling pathways. Dendrin appears to prevent programmed cell death (apoptosis) through its binding to nephrin. The SD protein nephrin serves as a component of a signalling complex that directly links podocyte junctional integrity to actin cytoskeletal dynamics. Thus, dendrin is identified as an SD family with proapoptotic signalling properties that accumulates in the podocyte nucleus in response to glomerular injury.",".",".",".",".","."]
["ENSRNOG00000070397",1064,89.51992584,585,37.63330634,2.378741986,1.250198796,{"v":5.67e-67,"d":"5.67E-67"},{"v":5.48e-66,"d":"5.48E-66"},"up","yes","C4b","protein_coding","chr20:4197366-4211681:+","gi|50657362|ref|NP_001002805.1|",9057,0,"complement component 4, gene 2 precursor [Rattus norvegicus]","gi|259013548|ref|NM_001002805.2|",5351,0,"Rattus norvegicus complement component 4B (Chido blood group) (C4b), mRNA","P08649",3423,0,"Complement C4","TM0984",61.2,{"v":3e-08,"d":"3.00E-08"},"COG2373","pfam07678","A2M_comp","A-macroglobulin complement component. This family includes the complement components region of the alpha-2-macroglobulin family.",".",".",".",".","."]
["ENSRNOG00000054251",539,45.3489098,178,11.450818,3.960320548,1.985617207,{"v":2.42e-66,"d":"2.42E-66"},{"v":2.31e-65,"d":"2.31E-65"},"up","yes","Clec7a","protein_coding","chr4:162902732-162913897:-","gi|187469451|gb|AAI66774.1|",1303,{"v":1e-171,"d":"1.00E-171"},"Clec7a protein [Rattus norvegicus]","gi|290563187|ref|NM_001173386.1|",2426,0,"Rattus norvegicus C-type lectin domain family 7, member A (Clec7a), mRNA","Q6QLQ4",399,{"v":1e-131,"d":"1.00E-131"},"C-type lectin domain family 7 member A",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0001879|detection of yeast;GO:0002223|stimulatory C-type lectin receptor signaling pathway;GO:0002366|leukocyte activation involved in immune response;GO:0002732|positive regulation of dendritic cell cytokine production;GO:0006910|phagocytosis, recognition;GO:0008037|cell recognition;GO:0008284|positive regulation of cell proliferation;GO:0010628|positive regulation of gene expression;GO:0016046|detection of fungus;GO:0030335|positive regulation of cell migration;GO:0031334|positive regulation of protein complex assembly;GO:0032491|detection of molecule of fungal origin;GO:0032729|positive regulation of interferon-gamma production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032733|positive regulation of interleukin-10 production;GO:0032735|positive regulation of interleukin-12 production;GO:0032743|positive regulation of interleukin-2 production;GO:0032747|positive regulation of interleukin-23 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032874|positive regulation of stress-activated MAPK cascade;GO:0032930|positive regulation of superoxide anion generation;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043280|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050766|positive regulation of phagocytosis;GO:0050850|positive regulation of calcium-mediated signaling;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051251|positive regulation of lymphocyte activation;GO:0051712|positive regulation of killing of cells of other organism;GO:0060267|positive regulation of respiratory burst;GO:0061760|antifungal innate immune response;GO:0070884|regulation of calcineurin-NFAT signaling cascade;GO:0071226|cellular response to molecule of fungal origin;GO:0071639|positive regulation of monocyte chemotactic protein-1 production;GO:0090303|positive regulation of wound healing;GO:1900017|positive regulation of cytokine production involved in inflammatory response;GO:1903431|positive regulation of cell maturation;GO:2000318|positive regulation of T-helper 17 type immune response;","GO:0005737|cytoplasm;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0001872|(1->3)-beta-D-glucan binding;GO:0030246|carbohydrate binding;GO:0038187|pattern recognition receptor activity;GO:0042802|identical protein binding;","K10074","CLEC7A, DECTIN1, CD369; C-type lectin domain family 7 member A"]
["ENSRNOG00000046663",465,39.12289992,130,8.362956964,4.678118049,2.225928268,{"v":3.5E-66,"d":"3.50E-66"},3.31E-65,"up","yes","Fcgr2a","protein_coding","chr13:83280790-83484920:-","gi|672074912|ref|XP_008767999.1|",1263,{"v":4e-164,"d":"4.00E-164"},"PREDICTED: low affinity immunoglobulin gamma Fc region receptor III-like isoform X2 [Rattus norvegicus]","gi|298894770|emb|FQ230932.1|",1294,0,"Rattus norvegicus TL0AEA7YO18 mRNA sequence","P27645",482,{"v":3E-162,"d":"3.00E-162"},"Low affinity immunoglobulin gamma Fc region receptor III",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0001788|antibody-dependent cellular cytotoxicity;GO:0001798|positive regulation of type IIa hypersensitivity;GO:0001805|positive regulation of type III hypersensitivity;GO:0001812|positive regulation of type I hypersensitivity;GO:0001813|regulation of antibody-dependent cellular cytotoxicity;GO:0001820|serotonin secretion;GO:0006910|phagocytosis, recognition;GO:0006911|phagocytosis, engulfment;GO:0007166|cell surface receptor signaling pathway;GO:0021675|nerve development;GO:0030593|neutrophil chemotaxis;GO:0032680|regulation of tumor necrosis factor production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0038094|Fc-gamma receptor signaling pathway;GO:0042590|antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:0045576|mast cell activation;GO:0050766|positive regulation of phagocytosis;GO:0050776|regulation of immune response;GO:1905449|regulation of Fc-gamma receptor signaling pathway involved in phagocytosis;","GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0004888|transmembrane signaling receptor activity;GO:0019770|IgG receptor activity;GO:0019864|IgG binding;GO:0034987|immunoglobulin receptor binding;","K06463","FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor IIIK06463; K06472"]
["ENSRNOG00000026235",367,30.87764359,72,4.631791549,6.666457949,2.736920426,3.75E-66,{"v":3.54e-65,"d":"3.54E-65"},"up","yes","Hk3","protein_coding","chr17:9599865-9614863:+","gi|564390462|ref|XP_006253664.1|",4788,0,"PREDICTED: hexokinase-3 isoform X1 [Rattus norvegicus]","gi|672081088|ref|XM_008771484.1|",2987,0,"PREDICTED: Rattus norvegicus hexokinase 3 (white cell) (Hk3), transcript variant X2, mRNA","P27926",1846,0,"Hexokinase-3","SPAC24H6.04",276,{"v":7e-81,"d":"7.00E-81"},"COG5026","pfam03727","Hexokinase_2","Hexokinase. Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam00349. Some members of the family have two copies of each of these domains.","GO:0001678|cellular glucose homeostasis;GO:0006002|fructose 6-phosphate metabolic process;GO:0006096|glycolytic process;GO:0008150|biological_process;GO:0019318|hexose metabolic process;GO:0046835|carbohydrate phosphorylation;GO:0051156|glucose 6-phosphate metabolic process;GO:1901299|negative regulation of hydrogen peroxide-mediated programmed cell death;","GO:0005739|mitochondrion;GO:0005829|cytosol;GO:0032991|protein-containing complex;","GO:0004340|glucokinase activity;GO:0004396|hexokinase activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0005536|glucose binding;GO:0008865|fructokinase activity;GO:0019158|mannokinase activity;GO:0019899|enzyme binding;GO:0042562|hormone binding;","K00844","HK; hexokinase [EC:2.7.1.1]"]
["ENSRNOG00000023614",259,21.79103458,19,1.222278326,17.82820993,4.156089949,{"v":7.73e-66,"d":"7.73E-66"},{"v":7.26e-65,"d":"7.26E-65"},"up","yes","Hsh2d","protein_coding","chr16:17635322-17647991:-","gi|404501493|ref|NP_001258257.1|",1584,0,"hematopoietic SH2 domain-containing protein [Rattus norvegicus]","gi|404501492|ref|NM_001271328.1|",2176,0,"Rattus norvegicus hematopoietic SH2 domain containing (Hsh2d), mRNA","Q6VYH9",509,{"v":3e-174,"d":"3.00E-174"},"Hematopoietic SH2 domain-containing protein",".",".",".",".","pfam00017","SH2","SH2 domain.","GO:0002903|negative regulation of B cell apoptotic process;GO:0007165|signal transduction;GO:0042110|T cell activation;GO:0051902|negative regulation of mitochondrial depolarization;","GO:0005739|mitochondrion;GO:0005829|cytosol;","GO:0030674|protein binding, bridging;","K23699","HSH2D; hematopoietic SH2 domain-containing protein"]
["ENSRNOG00000028566",776,65.28896847,355,22.83730556,2.858873535,1.515446803,{"v":1.66e-65,"d":"1.66E-65"},{"v":1.55e-64,"d":"1.55E-64"},"up","yes","Pld4","protein_coding","chr6:131818860-131826376:+","gi|187281923|ref|NP_001119760.1|",2755,0,"phospholipase D4 [Rattus norvegicus]","gi|187281922|ref|NM_001126288.1|",1989,0,"Rattus norvegicus phospholipase D family, member 4 (Pld4), mRNA","Q8BG07",876,0,"Phospholipase D4",".",".",".",".","pfam13918","PLDc_3","PLD-like domain.","GO:0002244|hematopoietic progenitor cell differentiation;GO:0006259|DNA metabolic process;GO:0006909|phagocytosis;GO:0090305|nucleic acid phosphodiester bond hydrolysis;GO:1900015|regulation of cytokine production involved in inflammatory response;","GO:0005634|nucleus;GO:0005769|early endosome;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0032588|trans-Golgi network membrane;GO:0045335|phagocytic vesicle;","GO:0045145|single-stranded DNA 5'-3' exodeoxyribonuclease activity;","K16860","PLD3_4; phospholipase D3/4 [EC:3.1.4.4]"]
["ENSRNOG00000058470",1267,106.5993854,771,49.59876784,2.149234548,1.103822934,{"v":1.9e-65,"d":"1.90E-65"},{"v":1.77e-64,"d":"1.77E-64"},"up","yes","Col12a1","protein_coding","chr8:80547593-80665686:-","gi|672023106|ref|XP_008756047.1|",14897,0,"PREDICTED: collagen alpha-1(XII) chain isoform X1 [Rattus norvegicus]","gi|672023105|ref|XM_008757825.1|",12409,0,"PREDICTED: Rattus norvegicus collagen, type XII, alpha 1 (Col12a1), transcript variant X1, mRNA","Q60847",5464,0,"Collagen alpha-1(XII) chain",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0007155|cell adhesion;GO:0035987|endodermal cell differentiation;","GO:0005576|extracellular region;GO:0005581|collagen trimer;GO:0005595|collagen type XII trimer;GO:0005615|extracellular space;GO:0062023|collagen-containing extracellular matrix;","GO:0005201|extracellular matrix structural constituent;","K08132","COL12A; collagen type XII alpha"]
["ENSRNOG00000008196",624,52.50040764,242,15.56796604,3.372335699,1.753748156,{"v":5.74e-65,"d":"5.74E-65"},{"v":5.29e-64,"d":"5.29E-64"},"up","yes","Parp12","protein_coding","chr4:67839237-67883685:-","gi|392339871|ref|XP_003753925.1|",3495,0,"PREDICTED: poly [ADP-ribose] polymerase 12 isoform X1 [Rattus norvegicus]","gi|672049407|ref|XM_003749716.3|",2870,0,"PREDICTED: Rattus norvegicus poly (ADP-ribose) polymerase family, member 12 (Parp12), transcript variant X1, mRNA","Q8BZ20",1247,0,"Poly [ADP-ribose] polymerase 12",".",".",".",".","pfam00644","PARP","Poly(ADP-ribose) polymerase catalytic domain. Poly(ADP-ribose) polymerase catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The carboxyl-terminal region is the most highly conserved region of the protein. Experiments have shown that a carboxyl 40 kDa fragment is still catalytically active.","GO:0008150|biological_process;GO:0070213|protein auto-ADP-ribosylation;","GO:0005575|cellular_component;","GO:0003674|molecular_function;GO:0003950|NAD+ ADP-ribosyltransferase activity;GO:0046872|metal ion binding;GO:1990404|protein ADP-ribosylase activity;","K15259","PARP7S; poly [ADP-ribose] polymerase 7/11/12/13 [EC:2.4.2.30]"]
["ENSRNOG00000052444",1131,95.15698884,654,42.07210657,2.26175955,1.177445563,{"v":8.07e-65,"d":"8.07E-65"},{"v":7.41e-64,"d":"7.41E-64"},"up","yes","Samd9","protein_coding","chr4:31164510-31184322:-","gi|109471717|ref|XP_575365.2|",8244,0,"PREDICTED: sterile alpha motif domain-containing protein 9 [Rattus norvegicus]","gi|672018002|ref|XM_006224823.2|",5080,0,"PREDICTED: Rattus norvegicus similar to OEF2 (RGD1563091), transcript variant X2, mRNA","Q5K651",2419,0,"Sterile alpha motif domain-containing protein 9",".",".",".",".","pfam10310","DUF2413","Protein of unknown function (DUF2413). This is a family of proteins conserved in fungi. The function is not known.","GO:0002244|hematopoietic progenitor cell differentiation;GO:0017145|stem cell division;GO:0034058|endosomal vesicle fusion;GO:0035726|common myeloid progenitor cell proliferation;GO:0042176|regulation of protein catabolic process;GO:0048536|spleen development;","GO:0005737|cytoplasm;GO:0005769|early endosome;GO:0005829|cytosol;GO:0043231|intracellular membrane-bounded organelle;",".","K23949","SAMD9, SAMD9L; sterile alpha motif domain-contaning protein 9"]
["ENSRNOG00000009471",311,26.16606855,46,2.959200157,8.842277361,3.144417989,{"v":2.66e-64,"d":"2.66E-64"},{"v":2.43e-63,"d":"2.43E-63"},"up","yes","Epsti1","protein_coding","chr15:53284216-53382191:+","gi|112984176|ref|NP_001037722.1|",1643,0,"epithelial-stromal interaction protein 1 [Rattus norvegicus]","gi|112984175|ref|NM_001044257.1|",1550,0,"Rattus norvegicus epithelial stromal interaction 1 (breast) (Epsti1), mRNA",".",".",".",".",".",".",".",".","pfam15558","DUF4659","Domain of unknown function (DUF4659). This family of proteins is found in eukaryotes. Proteins in this family are typically between 427 and 674 amino acids in length. There are two completely conserved residues (D and I) that may be functionally important.",".",".",".",".","."]
["ENSRNOG00000022764",240,20.19246448,13,0.836295696,24.14512542,4.593660052,{"v":4.29e-64,"d":"4.29E-64"},3.89E-63,"up","yes","Evi2a","protein_coding","chr10:64485200-64489843:-","gi|112983874|ref|NP_001037752.1|",1170,{"v":1E-150,"d":"1.00E-150"},"protein EVI2A precursor [Rattus norvegicus]","gi|281371508|gb|AC123294.3|",2519,0,"Rattus norvegicus BAC CH230-333F9 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P20934",379,{"v":6e-123,"d":"6.00E-123"},"Protein EVI2A",".",".",".",".","pfam05399","EVI2A","Ectropic viral integration site 2A protein (EVI2A). This family contains several mammalian ectropic viral integration site 2A (EVI2A) proteins. The function of this protein is unknown although it is thought to be a membrane protein and may function as an oncogene in retrovirus induced myeloid tumors.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000033747",1243,104.5801389,758,48.76247214,2.144684925,1.100765718,{"v":5.79e-64,"d":"5.79E-64"},{"v":5.22e-63,"d":"5.22E-63"},"up","yes","Sp110","protein_coding","chr9:86200503-86222670:-","gi|77628031|ref|NP_001029309.1|",2417,0,"sp110 nuclear body protein [Rattus norvegicus]","gi|77628030|ref|NM_001034137.1|",1762,0,"Rattus norvegicus SP110 nuclear body protein (Sp110), mRNA","Q3KRF1",935,0,"Sp110 nuclear body protein",".",".",".",".","pfam03172","Sp100","Sp100 domain. The function of this domain is unknown. It is about 105 amino acid residues in length and is predicted to be predominantly alpha helical. This domain is usually found at the amino terminus of protein that contain a SAND domain pfam01342.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0006915|apoptotic process;GO:0009617|response to bacterium;GO:0043065|positive regulation of apoptotic process;GO:0045087|innate immune response;","GO:0005634|nucleus;GO:0005654|nucleoplasm;","GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677|DNA binding;","K24503","SP110; nuclear body protein Sp110"]
["ENSRNOG00000005964",571,48.0412384,209,13.44506158,3.573151235,1.837196978,{"v":2e-63,"d":"2.00E-63"},1.78E-62,"up","yes","Nr4a3","protein_coding","chr5:62361822-62402733:+","gi|672052568|ref|XP_008761925.1|",2752,0,"PREDICTED: nuclear receptor subfamily 4 group A member 3 isoform X2 [Rattus norvegicus]","gi|82393808|gb|DQ268830.1|",5368,0,"Rattus norvegicus neuron-derived orphan receptor 1 mRNA, complete cds","P51179",1009,0,"Nuclear receptor subfamily 4 group A member 3",".",".",".",".","pfam00105","zf-C4","Zinc finger, C4 type (two domains). In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001707|mesoderm formation;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007369|gastrulation;GO:0007411|axon guidance;GO:0009444|pyruvate oxidation;GO:0010613|positive regulation of cardiac muscle hypertrophy;GO:0010828|positive regulation of glucose transmembrane transport;GO:0021766|hippocampus development;GO:0030522|intracellular receptor signaling pathway;GO:0030534|adult behavior;GO:0031100|animal organ regeneration;GO:0032765|positive regulation of mast cell cytokine production;GO:0035726|common myeloid progenitor cell proliferation;GO:0038097|positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway;GO:0042472|inner ear morphogenesis;GO:0042542|response to hydrogen peroxide;GO:0043066|negative regulation of apoptotic process;GO:0043303|mast cell degranulation;GO:0043434|response to peptide hormone;GO:0043524|negative regulation of neuron apoptotic process;GO:0044320|cellular response to leptin stimulus;GO:0045333|cellular respiration;GO:0045444|fat cell differentiation;GO:0045787|positive regulation of cell cycle;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046321|positive regulation of fatty acid oxidation;GO:0048008|platelet-derived growth factor receptor signaling pathway;GO:0048660|regulation of smooth muscle cell proliferation;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0048752|semicircular canal morphogenesis;GO:0050679|positive regulation of epithelial cell proliferation;GO:0050885|neuromuscular process controlling balance;GO:0060005|vestibular reflex;GO:0061469|regulation of type B pancreatic cell proliferation;GO:0071376|cellular response to corticotropin-releasing hormone stimulus;GO:0071870|cellular response to catecholamine stimulus;GO:0097009|energy homeostasis;GO:1900625|positive regulation of monocyte aggregation;GO:1903204|negative regulation of oxidative stress-induced neuron death;GO:1903208|negative regulation of hydrogen peroxide-induced neuron death;GO:1904707|positive regulation of vascular smooth muscle cell proliferation;GO:1904754|positive regulation of vascular associated smooth muscle cell migration;GO:2000108|positive regulation of leukocyte apoptotic process;GO:2000253|positive regulation of feeding behavior;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001223|transcription coactivator binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0004879|nuclear receptor activity;GO:0005515|protein binding;GO:0008270|zinc ion binding;GO:0019901|protein kinase binding;GO:0035035|histone acetyltransferase binding;GO:0035259|glucocorticoid receptor binding;GO:0035497|cAMP response element binding;GO:0042803|protein homodimerization activity;GO:0043565|sequence-specific DNA binding;","K08559","NR4A3, NOR1; nuclear receptor subfamily 4 group A member 3"]
["ENSRNOG00000047573",1140,95.91420626,672,43.23005446,2.2186927,1.149709861,{"v":5.98e-63,"d":"5.98E-63"},{"v":5.3e-62,"d":"5.30E-62"},"up","yes","Ttc39a","protein_coding","chr5:124151760-124204973:+","gi|197386204|ref|NP_001127991.1|",3098,0,"tetratricopeptide repeat protein 39A [Rattus norvegicus]","gi|197386203|ref|NM_001134519.1|",2644,0,"Rattus norvegicus tetratricopeptide repeat domain 39A (Ttc39a), mRNA",".",".",".",".",".",".",".",".","pfam10300","DUF3808","Protein of unknown function (DUF3808). This is a family of proteins conserved from fungi to humans. Members of this family also carry a TPR_2 domain pfam07719 at their C-terminus.",".","GO:0005813|centrosome;",".","K24943","TTC39; tetratricopeptide repeat protein 39"]
["ENSRNOG00000000457",864,72.69287211,437,28.11240149,2.585793752,1.370607207,{"v":8.26e-63,"d":"8.26E-63"},{"v":7.3e-62,"d":"7.30E-62"},"up","yes","Tap1","protein_coding","chr20:4656263-4666901:-","gi|56717|emb|CAA40742.1|",3336,0,"mtp1 [Rattus norvegicus]","gi|74355727|gb|BC101854.1|",2886,0,"Rattus norvegicus transporter 1, ATP-binding cassette, sub-family B (MDR/TAP), mRNA (cDNA clone MGC:124549 IMAGE:7933924), complete cds","P36370",1267,0,"Antigen peptide transporter 1",".",".",".",".","pfam00664","ABC_membrane","ABC transporter transmembrane region. This family represents a unit of six transmembrane helices. Many members of the ABC transporter family (pfam00005) have two such regions.","GO:0002250|adaptive immune response;GO:0002479|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0006952|defense response;GO:0015031|protein transport;GO:0015833|peptide transport;GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0042270|protection from natural killer cell mediated cytotoxicity;GO:0046967|cytosol to ER transport;GO:0046968|peptide antigen transport;GO:0055085|transmembrane transport;","GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;GO:0030176|integral component of endoplasmic reticulum membrane;GO:0034451|centriolar satellite;GO:0042824|MHC class I peptide loading complex;GO:0042825|TAP complex;GO:0043231|intracellular membrane-bounded organelle;","GO:0000166|nucleotide binding;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0015433|peptide antigen-transporting ATPase activity;GO:0015440|peptide-transporting ATPase activity;GO:0016887|ATPase activity;GO:0023029|MHC class Ib protein binding;GO:0042288|MHC class I protein binding;GO:0042605|peptide antigen binding;GO:0042626|ATPase activity, coupled to transmembrane movement of substances;GO:0042803|protein homodimerization activity;GO:0043531|ADP binding;GO:0044877|protein-containing complex binding;GO:0046872|metal ion binding;GO:0046978|TAP1 binding;GO:0046979|TAP2 binding;GO:0046980|tapasin binding;GO:1904680|peptide transmembrane transporter activity;","K05653","ABCB2, TAP1; ATP-binding cassette, subfamily B (MDR/TAP), member 2 [EC:7.4.2.14]"]
["ENSRNOG00000013267",956,80.43331683,514,33.06584523,2.432519607,1.282451434,{"v":9.8e-63,"d":"9.80E-63"},{"v":8.65e-62,"d":"8.65E-62"},"up","yes","Helz2","protein_coding","chr3:168338813-168353159:-","gi|765826399|ref|NP_001292205.1|",15424,0,"peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein [Rattus norvegicus]","gi|765826398|ref|NM_001305276.1|",10042,0,"Rattus norvegicus helicase with zinc finger 2, transcriptional coactivator (Helz2), mRNA","E9QAM5",5251,0,"Helicase with zinc finger domain 2","SPAC16C9.06c",194,{"v":5e-49,"d":"5.00E-49"},"COG1112","pfam13087","AAA_12","AAA domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.","GO:0032508|DNA duplex unwinding;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0090501|RNA phosphodiester bond hydrolysis;","GO:0005634|nucleus;","GO:0003723|RNA binding;GO:0004540|ribonuclease activity;GO:0030374|nuclear receptor transcription coactivator activity;GO:0043139|5'-3' DNA helicase activity;","K25165","HELZ2; helicase with zinc finger domain 2 [EC:3.6.4.-]"]
["ENSRNOG00000036603",417,35.08440703,109,7.012017762,5.003468077,2.322928423,{"v":1.33e-62,"d":"1.33E-62"},{"v":1.17e-61,"d":"1.17E-61"},"up","yes","Ifit1bl","protein_coding","chr1:232122562-232167518:-","gi|293344709|ref|XP_001079971.2|",2456,0,"PREDICTED: interferon-induced protein with tetratricopeptide repeats 1 isoform X2 [Rattus norvegicus]","gi|672014796|ref|XM_001079971.4|",2564,0,"PREDICTED: Rattus norvegicus interferon-induced protein with tetratricopeptide repeats 1-like B (Ifit1lb), transcript variant X2, mRNA","Q64282",550,0,"Interferon-induced protein with tetratricopeptide repeats 1",".",".",".",".","pfam13414","TPR_11","TPR repeat.","GO:0050688|regulation of defense response to virus;GO:0051607|defense response to virus;GO:0071357|cellular response to type I interferon;GO:0071360|cellular response to exogenous dsRNA;","GO:0005829|cytosol;","GO:0003723|RNA binding;","K14217","IFIT1; interferon-induced protein with tetratricopeptide repeats 1"]
["ENSRNOG00000049115",402,33.822378,100,6.433043818,5.257601059,2.394404676,{"v":1.49e-62,"d":"1.49E-62"},1.31E-61,"up","yes","Ccr5","protein_coding","chr8:123752325-123759260:+","gi|51592090|ref|NP_446412.2|",1670,0,"C-C chemokine receptor type 5 [Rattus norvegicus]","gi|82617607|ref|NM_053960.3|",2492,0,"Rattus norvegicus chemokine (C-C motif) receptor 5 (Ccr5), mRNA","O08556",639,0,"C-C chemokine receptor type 5",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0000165|MAPK cascade;GO:0002437|inflammatory response to antigenic stimulus;GO:0006816|calcium ion transport;GO:0006935|chemotaxis;GO:0006952|defense response;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007267|cell-cell signaling;GO:0007568|aging;GO:0010212|response to ionizing radiation;GO:0010628|positive regulation of gene expression;GO:0014808|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0019722|calcium-mediated signaling;GO:0022409|positive regulation of cell-cell adhesion;GO:0023052|signaling;GO:0030336|negative regulation of cell migration;GO:0030517|negative regulation of axon extension;GO:0030900|forebrain development;GO:0031622|positive regulation of fever generation;GO:0032496|response to lipopolysaccharide;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032755|positive regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0042742|defense response to bacterium;GO:0045444|fat cell differentiation;GO:0045666|positive regulation of neuron differentiation;GO:0050729|positive regulation of inflammatory response;GO:0050900|leukocyte migration;GO:0060139|positive regulation of apoptotic process by virus;GO:0060326|cell chemotaxis;GO:0070098|chemokine-mediated signaling pathway;GO:0070723|response to cholesterol;GO:0070997|neuron death;GO:0071222|cellular response to lipopolysaccharide;GO:2000110|negative regulation of macrophage apoptotic process;GO:2000178|negative regulation of neural precursor cell proliferation;","GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0003779|actin binding;GO:0005515|protein binding;GO:0016493|C-C chemokine receptor activity;GO:0019901|protein kinase binding;GO:0019957|C-C chemokine binding;GO:0042802|identical protein binding;GO:0071791|chemokine (C-C motif) ligand 5 binding;","K04180","CCR5, CD195; C-C chemokine receptor type 5"]
["ENSRNOG00000019445",223,18.76216491,7,0.450313067,41.66471344,5.380754153,{"v":2.95e-62,"d":"2.95E-62"},{"v":2.58e-61,"d":"2.58E-61"},"up","yes","Msln","protein_coding","chr10:14771961-14777643:-","gi|564371087|ref|XP_006246083.1|",3003,0,"PREDICTED: mesothelin isoform X1 [Rattus norvegicus]","gi|14389304|ref|NM_031658.1|",2063,0,"Rattus norvegicus mesothelin (Msln), mRNA","Q9ERA7",1163,0,"Mesothelin",".",".",".",".","pfam06060","Mesothelin","Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin). This family consists of several mammalian pre-pro-megakaryocyte potentiating factor precursor (MPF) or mesothelin proteins. Mesothelin is a glycosylphosphatidylinositol-linked glycoprotein highly expressed in mesothelial cells, mesotheliomas, and ovarian cancer, but the biological function of the protein is not known.","GO:0007160|cell-matrix adhesion;GO:0031016|pancreas development;","GO:0005615|extracellular space;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0031225|anchored component of membrane;","GO:0003674|molecular_function;","K20733","MSLN; mesothelin"]
["ENSRNOG00000013014",1228,103.3181099,755,48.56948083,2.12722286,1.088971186,{"v":3.75e-62,"d":"3.75E-62"},{"v":3.27e-61,"d":"3.27E-61"},"up","yes","Cyba","protein_coding","chr19:50487597-50495721:-","gi|13162359|ref|NP_077074.1|",819,{"v":9e-108,"d":"9.00E-108"},"cytochrome b-245 light chain [Rattus norvegicus]","gi|13162358|ref|NM_024160.1|",656,0,"Rattus norvegicus cytochrome b-245, alpha polypeptide (Cyba), mRNA","Q62737",320,{"v":3e-109,"d":"3.00E-109"},"Cytochrome b-245 light chain",".",".",".",".","pfam05038","Cytochrom_B558a","Cytochrome Cytochrome b558 alpha-subunit. Cytochrome b-245 light chain (p22-phox) is one of the key electron transfer elements of the NADPH oxidase in phagocytes.","GO:0001666|response to hypoxia;GO:0001938|positive regulation of endothelial cell proliferation;GO:0003106|negative regulation of glomerular filtration by angiotensin;GO:0006801|superoxide metabolic process;GO:0006954|inflammatory response;GO:0009410|response to xenobiotic stimulus;GO:0014823|response to activity;GO:0014895|smooth muscle hypertrophy;GO:0017004|cytochrome complex assembly;GO:0022900|electron transport chain;GO:0030307|positive regulation of cell growth;GO:0031667|response to nutrient levels;GO:0032755|positive regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032930|positive regulation of superoxide anion generation;GO:0033864|positive regulation of NAD(P)H oxidase activity;GO:0034137|positive regulation of toll-like receptor 2 signaling pathway;GO:0042554|superoxide anion generation;GO:0045087|innate immune response;GO:0045730|respiratory burst;GO:0045777|positive regulation of blood pressure;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0050665|hydrogen peroxide biosynthetic process;GO:0050766|positive regulation of phagocytosis;GO:0051279|regulation of release of sequestered calcium ion into cytosol;GO:0070257|positive regulation of mucus secretion;GO:0070555|response to interleukin-1;GO:0071230|cellular response to amino acid stimulus;GO:0071260|cellular response to mechanical stimulus;GO:0071310|cellular response to organic substance;GO:0071333|cellular response to glucose stimulus;GO:0071356|cellular response to tumor necrosis factor;GO:0071407|cellular response to organic cyclic compound;GO:0071480|cellular response to gamma radiation;GO:0072593|reactive oxygen species metabolic process;GO:1900426|positive regulation of defense response to bacterium;GO:1903428|positive regulation of reactive oxygen species biosynthetic process;GO:1904044|response to aldosterone;GO:1904385|cellular response to angiotensin;GO:1904845|cellular response to L-glutamine;GO:2000376|positive regulation of oxygen metabolic process;","GO:0001725|stress fiber;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005794|Golgi apparatus;GO:0005925|focal adhesion;GO:0016324|apical plasma membrane;GO:0030425|dendrite;GO:0043020|NADPH oxidase complex;GO:0043025|neuronal cell body;GO:0097038|perinuclear endoplasmic reticulum;","GO:0005515|protein binding;GO:0009055|electron transfer activity;GO:0016175|superoxide-generating NADPH oxidase activity;GO:0017124|SH3 domain binding;GO:0020037|heme binding;GO:0046872|metal ion binding;GO:0046982|protein heterodimerization activity;","K08009","CYBA, P22PHOX; cytochrome b-245, alpha polypeptide"]
["ENSRNOG00000003546",1209,101.7195398,744,47.86184601,2.12527406,1.087648893,{"v":4.21e-61,"d":"4.21E-61"},{"v":3.62e-60,"d":"3.62E-60"},"up","yes","Tnfrsf12a","protein_coding","chr10:12689890-12709045:-","gi|524963570|ref|XP_005081703.1|",379,{"v":1e-44,"d":"1.00E-44"},"PREDICTED: tumor necrosis factor receptor superfamily member 12A [Mesocricetus auratus]","gi|298914578|emb|FQ229590.1|",847,0,"Rattus norvegicus TL0ADA47YG14 mRNA sequence","Q9NP84",146,{"v":5e-41,"d":"5.00E-41"},"Tumor necrosis factor receptor superfamily member 12A",".",".",".",".","pfam12191","stn_TNFRSF12A","tumor necrosis factor receptor stn_TNFRSF12A_TNFR domain. This family of proteins is found in eukaryotes. Proteins in this family are typically between 129 and 184 amino acids in length. This is the stn_TNFRSF12A_TNFR domain from the tumor necrosis factor receptor. The function of this domain is unknown.","GO:0006931|substrate-dependent cell migration, cell attachment to substrate;GO:0007155|cell adhesion;GO:0043065|positive regulation of apoptotic process;GO:0045765|regulation of angiogenesis;GO:0045773|positive regulation of axon extension;GO:0061041|regulation of wound healing;GO:0097191|extrinsic apoptotic signaling pathway;GO:2001238|positive regulation of extrinsic apoptotic signaling pathway;","GO:0001726|ruffle;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;",".","K05149","TNFRSF12A, FN14, TWEAKR, CD266; tumor necrosis factor receptor superfamily member 12A"]
["ENSRNOG00000034191",839,70.58949039,425,27.34043623,2.581871401,1.368417144,{"v":6.7e-61,"d":"6.70E-61"},{"v":5.75e-60,"d":"5.75E-60"},"up","yes","Fmo1","protein_coding","chr13:75182176-75214647:-","gi|564381434|ref|XP_006250207.1|",2764,0,"PREDICTED: dimethylaniline monooxygenase [N-oxide-forming] 1 isoform X1 [Rattus norvegicus]","gi|298904203|emb|FQ218919.1|",2230,0,"Rattus norvegicus TL0ABA49YB18 mRNA sequence","P36365",1069,0,"Dimethylaniline monooxygenase [N-oxide-forming] 1","CC0774",192,{"v":2E-52,"d":"2.00E-52"},"COG2072","pfam00743","FMO-like","Flavin-binding monooxygenase-like. This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.","GO:0006082|organic acid metabolic process;GO:0006805|xenobiotic metabolic process;GO:0006970|response to osmotic stress;GO:0009404|toxin metabolic process;GO:0032496|response to lipopolysaccharide;GO:0070995|NADPH oxidation;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0004497|monooxygenase activity;GO:0004499|N,N-dimethylaniline monooxygenase activity;GO:0050660|flavin adenine dinucleotide binding;GO:0050661|NADP binding;","K00485","FMO; dimethylaniline monooxygenase (N-oxide forming) / hypotaurine monooxygenase [EC:1.14.13.8 1.8.1.-]"]
["ENSRNOG00000014496",1148,96.58728841,693,44.58099366,2.16655755,1.115404559,{"v":1.88e-60,"d":"1.88E-60"},{"v":1.6E-59,"d":"1.60E-59"},"up","yes","Coro6","protein_coding","chr10:62311660-62319659:+","gi|564373190|ref|XP_006246948.1|",2431,0,"PREDICTED: coronin-6 isoform X6 [Rattus norvegicus]","gi|672068372|ref|XM_006246886.2|",2789,0,"PREDICTED: Rattus norvegicus coronin 6 (Coro6), transcript variant X6, mRNA","Q920M5",926,0,"Coronin-6",".",".",".",".","pfam08954","DUF1900","Domain of unknown function (DUF1900). This domain is predominantly found in the structural protein coronin, and is duplicated in some sequences. It has no known function.","GO:0007015|actin filament organization;GO:0016477|cell migration;",".","GO:0051015|actin filament binding;","K13886","CORO1B_1C_6; coronin-1B/1C/6"]
["ENSRNOG00000031138",451,37.94500616,138,8.87760047,4.274241254,2.095668341,{"v":1.04e-59,"d":"1.04E-59"},{"v":8.75e-59,"d":"8.75E-59"},"up","yes","Irgm","protein_coding","chr10:33233455-33241578:-","gi|58865582|ref|NP_001012007.1|",2100,0,"immunity-related GTPase family M protein [Rattus norvegicus]","gi|58865581|ref|NM_001012007.1|",2208,0,"Rattus norvegicus immunity-related GTPase family, M (Irgm), mRNA","Q6AYC2",813,0,"Immunity-related GTPase family M protein",".",".",".",".","pfam05049","IIGP","Interferon-inducible GTPase (IIGP). Interferon-inducible GTPase (IIGP) is thought to play a role in in intracellular defence. IIGP is predominantly associated with the Golgi apparatus and also localizes to the endoplasmic reticulum and exerts a distinct role in IFN-induced intracellular membrane trafficking or processing.","GO:0000045|autophagosome assembly;GO:0001934|positive regulation of protein phosphorylation;GO:0006952|defense response;GO:0009617|response to bacterium;GO:0010508|positive regulation of autophagy;GO:0010800|positive regulation of peptidyl-threonine phosphorylation;GO:0031648|protein destabilization;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0035458|cellular response to interferon-beta;GO:0042742|defense response to bacterium;GO:0043254|regulation of protein complex assembly;GO:0045087|innate immune response;GO:0050821|protein stabilization;GO:0050829|defense response to Gram-negative bacterium;GO:0060335|positive regulation of interferon-gamma-mediated signaling pathway;GO:0061635|regulation of protein complex stability;GO:0061739|protein lipidation involved in autophagosome assembly;GO:0061762|CAMKK-AMPK signaling cascade;GO:0070431|nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0071222|cellular response to lipopolysaccharide;GO:0071346|cellular response to interferon-gamma;GO:0071902|positive regulation of protein serine/threonine kinase activity;GO:0075044|autophagy of host cells involved in interaction with symbiont;GO:0098586|cellular response to virus;GO:1901098|positive regulation of autophagosome maturation;","GO:0000139|Golgi membrane;GO:0000421|autophagosome membrane;GO:0001891|phagocytic cup;GO:0005739|mitochondrion;GO:0005764|lysosome;GO:0005770|late endosome;GO:0005776|autophagosome;GO:0005789|endoplasmic reticulum membrane;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0030670|phagocytic vesicle membrane;GO:0042995|cell projection;GO:0044754|autolysosome;GO:0045335|phagocytic vesicle;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0019901|protein kinase binding;GO:0043539|protein serine/threonine kinase activator activity;GO:0050700|CARD domain binding;GO:0051434|BH3 domain binding;","K14139","IRGM, LRG47; immunity-related GTPase family M protein [EC:3.6.5.-]"]
["ENSRNOG00000013820",296,24.90403952,47,3.023530595,8.236741366,3.042073689,1.72E-59,1.44E-58,"up","yes","Tnfrsf14","protein_coding","chr5:165484262-165493703:-","gi|564354542|ref|XP_006239648.1|",1218,{"v":6e-154,"d":"6.00E-154"},"PREDICTED: tumor necrosis factor receptor superfamily member 14 isoform X1 [Rattus norvegicus]","gi|672054990|ref|XR_354472.2|",2791,0,"PREDICTED: Rattus norvegicus tumor necrosis factor receptor superfamily, member 14 (Tnfrsf14), transcript variant X2, misc_RNA","Q92956",177,{"v":2e-47,"d":"2.00E-47"},"Tumor necrosis factor receptor superfamily member 14",".",".",".",".","pfam00020","TNFR_c6","TNFR/NGFR cysteine-rich region.","GO:0002720|positive regulation of cytokine production involved in immune response;GO:0008150|biological_process;GO:0031295|T cell costimulation;GO:0046642|negative regulation of alpha-beta T cell proliferation;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:1905675|negative regulation of adaptive immune memory response;GO:2000406|positive regulation of T cell migration;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0019955|cytokine binding;GO:0031625|ubiquitin protein ligase binding;","K05152","TNFRSF14, HVEM, CD270; tumor necrosis factor receptor superfamily member 14"]
["ENSRNOG00000006767",278,23.38960468,38,2.444556651,9.568035445,3.258222734,{"v":1.81e-59,"d":"1.81E-59"},1.51E-58,"up","yes","Cst7","protein_coding","chr3:139396850-139405557:+","gi|157820635|ref|NP_001099993.1|",711,{"v":6e-90,"d":"6.00E-90"},"cystatin-F precursor [Rattus norvegicus]","gi|157820634|ref|NM_001106523.1|",1140,0,"Rattus norvegicus cystatin F (Cst7), mRNA","O89098",244,{"v":2E-78,"d":"2.00E-78"},"Cystatin-F",".",".",".",".","pfam00031","Cystatin","Cystatin domain. Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 are related to this family but have not been included.","GO:0006955|immune response;GO:0010466|negative regulation of peptidase activity;GO:0031643|positive regulation of myelination;GO:0097340|inhibition of cysteine-type endopeptidase activity;GO:1903979|negative regulation of microglial cell activation;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0005768|endosome;GO:0005770|late endosome;GO:0005771|multivesicular body;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0031410|cytoplasmic vesicle;","GO:0004869|cysteine-type endopeptidase inhibitor activity;GO:0030414|peptidase inhibitor activity;GO:0042803|protein homodimerization activity;","K13903","CST7; cystatin-F"]
["ENSRNOG00000002548",250,21.03381716,25,1.608260955,13.0786096,3.70913727,{"v":2.76e-59,"d":"2.76E-59"},{"v":2.3e-58,"d":"2.30E-58"},"up","yes","Tnn","protein_coding","chr13:72319155-72408156:-","gi|312922379|ref|NP_001100659.2|",8104,0,"tenascin-N precursor [Rattus norvegicus]","gi|672074420|ref|XM_008769642.1|",6185,0,"PREDICTED: Rattus norvegicus tenascin N (Tnn), transcript variant X1, mRNA","Q80Z71",3039,0,"Tenascin-N",".",".",".",".","pfam00147","Fibrinogen_C","Fibrinogen beta and gamma chains, C-terminal globular domain.","GO:0001764|neuron migration;GO:0002076|osteoblast development;GO:0007160|cell-matrix adhesion;GO:0007409|axonogenesis;GO:0033689|negative regulation of osteoblast proliferation;GO:0045668|negative regulation of osteoblast differentiation;GO:0070593|dendrite self-avoidance;GO:1905240|negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation;GO:1990138|neuron projection extension;GO:2001223|negative regulation of neuron migration;","GO:0005615|extracellular space;GO:0009986|cell surface;GO:0031012|extracellular matrix;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0062023|collagen-containing extracellular matrix;GO:0097442|CA3 pyramidal cell dendrite;GO:1990026|hippocampal mossy fiber expansion;","GO:0005178|integrin binding;GO:0042802|identical protein binding;","K06252","TN; tenascin"]
["ENSRNOG00000020557",460,38.70222358,146,9.392243975,4.120657819,2.042874667,{"v":5.8e-59,"d":"5.80E-59"},4.82E-58,"up","yes","Ryr1","protein_coding","chr1:84292578-84423812:-","gi|568945162|ref|XP_006539751.1|",23426,0,"PREDICTED: ryanodine receptor 1 isoform X7 [Mus musculus]","gi|755519244|ref|XM_006539688.2|",13203,0,"PREDICTED: Mus musculus ryanodine receptor 1, skeletal muscle (Ryr1), transcript variant X7, mRNA","E9PZQ0",8961,0,"Ryanodine receptor 1",".",".",".",".","pfam01365","RYDR_ITPR","RIH domain. The RIH (RyR and IP3R Homology) domain is an extracellular domain from two types of calcium channels. This region is found in the ryanodine receptor and the inositol-1,4,5- trisphosphate receptor. This domain may form a binding site for IP3.","GO:0001666|response to hypoxia;GO:0003151|outflow tract morphogenesis;GO:0006816|calcium ion transport;GO:0006936|muscle contraction;GO:0014808|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0031000|response to caffeine;GO:0032355|response to estradiol;GO:0043588|skin development;GO:0043931|ossification involved in bone maturation;GO:0048741|skeletal muscle fiber development;GO:0051209|release of sequestered calcium ion into cytosol;GO:0051289|protein homotetramerization;GO:0051480|regulation of cytosolic calcium ion concentration;GO:0070296|sarcoplasmic reticulum calcium ion transport;GO:0071277|cellular response to calcium ion;GO:0071313|cellular response to caffeine;GO:0071318|cellular response to ATP;","GO:0005737|cytoplasm;GO:0005790|smooth endoplasmic reticulum;GO:0005886|plasma membrane;GO:0005938|cell cortex;GO:0014802|terminal cisterna;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016529|sarcoplasmic reticulum;GO:0030018|Z disc;GO:0030314|junctional membrane complex;GO:0030315|T-tubule;GO:0030659|cytoplasmic vesicle membrane;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0031301|integral component of organelle membrane;GO:0031674|I band;GO:0032991|protein-containing complex;GO:0033017|sarcoplasmic reticulum membrane;GO:0034704|calcium channel complex;GO:0042383|sarcolemma;GO:1990425|ryanodine receptor complex;","GO:0002020|protease binding;GO:0005219|ryanodine-sensitive calcium-release channel activity;GO:0005245|voltage-gated calcium channel activity;GO:0005262|calcium channel activity;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0005516|calmodulin binding;GO:0005524|ATP binding;GO:0019899|enzyme binding;GO:0048763|calcium-induced calcium release activity;","K04961","RYR1; ryanodine receptor 1"]
["ENSRNOG00000011032",548,46.10612722,207,13.3164007,3.462356551,1.7917543,{"v":5.99e-59,"d":"5.99E-59"},4.96E-58,"up","yes","Lhfpl2","protein_coding","chr2:25281901-25427950:+","gi|157822913|ref|NP_001099872.1|",1152,{"v":1e-143,"d":"1.00E-143"},"lipoma HMGIC fusion partner-like 2 protein [Rattus norvegicus]","gi|157822912|ref|NM_001106402.1|",4250,0,"Rattus norvegicus lipoma HMGIC fusion partner-like 2 (Lhfpl2), mRNA","Q8BGA2",415,{"v":1e-132,"d":"1.00E-132"},"LHFPL tetraspan subfamily member 2 protein",".",".",".",".","pfam10242","L_HGMIC_fpl","Lipoma HMGIC fusion partner-like protein. This is a group of proteins expressed from a series of genes referred to as Lipoma HGMIC fusion partner-like. The proteins carry four highly conserved transmembrane domains in this entry. In certain instances, eg in LHFPL5, mutations cause deafness in humans and hypospadias, and LHFPL1 is transcribed in six liver tumor cell lines.","GO:0046545|development of primary female sexual characteristics;GO:0046546|development of primary male sexual characteristics;GO:1905516|positive regulation of fertilization;","GO:0016020|membrane;GO:0016021|integral component of membrane;",".","K23893","LHFPL; LHFPL tetraspan subfamily member protein"]
["ENSRNOG00000026965",630,53.00521925,269,17.30488787,3.063020092,1.614954831,1.51E-58,1.24E-57,"up","yes","Tmem140","protein_coding","chr4:63536168-63548455:+","gi|57527560|ref|NP_001009709.1|",664,{"v":1e-77,"d":"1.00E-77"},"transmembrane protein 140 [Rattus norvegicus]","gi|224458423|gb|AC103335.7|",2316,0,"Rattus norvegicus Mcs1 CH230-96K19 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q5M826",260,{"v":4E-79,"d":"4.00E-79"},"Transmembrane protein 140",".",".",".",".","pfam14985","TM140","TM140 protein family. This family of uncharacterized membrane proteins are called transmembrane protein 140. They are found in mammals.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000034190",263,22.12757565,33,2.12290446,10.42325553,3.381734045,{"v":4.13e-58,"d":"4.13E-58"},{"v":3.39e-57,"d":"3.39E-57"},"up","yes","Ighm","protein_coding","chr6:132329269-133053426:-","gi|56789191|gb|AAH88240.1|",2159,0,"IgG-2a protein [Rattus norvegicus]","gi|56789190|gb|BC088240.1|",1239,0,"Rattus norvegicus gamma-2a immunoglobulin heavy chain, mRNA (cDNA clone MGC:109023 IMAGE:7365825), complete cds","P20760",633,0,"Ig gamma-2A chain C region",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.","GO:0019731|antibacterial humoral response;GO:0050829|defense response to Gram-negative bacterium;","GO:0016021|integral component of membrane;GO:0071756|pentameric IgM immunoglobulin complex;GO:0071757|hexameric IgM immunoglobulin complex;","GO:0003697|single-stranded DNA binding;GO:0031210|phosphatidylcholine binding;GO:0042834|peptidoglycan binding;",".","."]
["ENSRNOG00000021644",370,31.1300494,92,5.918400313,5.2598756,2.395028679,{"v":9.78e-58,"d":"9.78E-58"},{"v":7.96e-57,"d":"7.96E-57"},"up","yes","Slc15a3","protein_coding","chr1:207492365-207507157:+","gi|21326469|ref|NP_647557.1|",2430,0,"solute carrier family 15 member 3 [Rattus norvegicus]","gi|21326468|ref|NM_139341.1|",1952,0,"Rattus norvegicus solute carrier family 15 member 3 (Slc15a3), mRNA","Q924V4",940,0,"Solute carrier family 15 member 3","SPBC13A2.04c",90.9,{"v":3e-18,"d":"3.00E-18"},"COG3104","pfam00854","PTR2","POT family. The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.","GO:0015031|protein transport;GO:0015835|peptidoglycan transport;GO:0030163|protein catabolic process;GO:0045087|innate immune response;GO:0070434|positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0140206|dipeptide import across plasma membrane;","GO:0005765|lysosomal membrane;GO:0010008|endosome membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0005427|proton-dependent oligopeptide secondary active transmembrane transporter activity;GO:0015293|symporter activity;GO:0015647|peptidoglycan transmembrane transporter activity;GO:0071916|dipeptide transmembrane transporter activity;","K14638","SLC15A3_4, PHT; solute carrier family 15 (peptide/histidine transporter), member 3/4"]
["ENSRNOG00000003480",251,21.11795243,28,1.801252269,11.72403932,3.551397807,{"v":1.1E-57,"d":"1.10E-57"},{"v":8.95e-57,"d":"8.95E-57"},"up","yes","Aim2","protein_coding","chr13:85866284-85906975:+","gi|293341479|ref|XP_001057147.2|",1564,0,"PREDICTED: interferon-inducible protein AIM2 [Rattus norvegicus]","gi|672027384|ref|XM_008763565.1|",1858,0,"PREDICTED: Rattus norvegicus absent in melanoma 2 (Aim2), transcript variant X4, mRNA","Q91VJ1",507,{"v":1E-174,"d":"1.00E-174"},"Interferon-inducible protein AIM2",".",".",".",".","pfam02760","HIN","HIN-200/IF120x domain. This domain has no know function. It is found in one or two copies per protein, and is found associated with the PAAD/DAPIN domain pfam02758.","GO:0002218|activation of innate immune response;GO:0002230|positive regulation of defense response to virus by host;GO:0008150|biological_process;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0032731|positive regulation of interleukin-1 beta production;GO:0033209|tumor necrosis factor-mediated signaling pathway;GO:0035458|cellular response to interferon-beta;GO:0044546|NLRP3 inflammasome complex assembly;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0070269|pyroptosis;GO:0071466|cellular response to xenobiotic stimulus;GO:1904270|pyroptosome complex assembly;GO:2001056|positive regulation of cysteine-type endopeptidase activity;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;GO:0097169|AIM2 inflammasome complex;","GO:0003674|molecular_function;GO:0003690|double-stranded DNA binding;GO:0042802|identical protein binding;","K12966","AIM2; absent in melanoma 2"]
["ENSRNOG00000009342",205,17.24773007,6,0.385982629,44.68524947,5.481726774,{"v":1.68e-57,"d":"1.68E-57"},{"v":1.36e-56,"d":"1.36E-56"},"up","yes","Fcnb","protein_coding","chr3:11393739-11402151:-","gi|16758442|ref|NP_446086.1|",1695,0,"ficolin-2 precursor [Rattus norvegicus]","gi|298888542|emb|FQ220557.1|",1162,0,"Rattus norvegicus TL0ADA42YH06 mRNA sequence","P57756",657,0,"Ficolin-2",".",".",".",".","pfam00147","Fibrinogen_C","Fibrinogen beta and gamma chains, C-terminal globular domain.","GO:0001867|complement activation, lectin pathway;GO:0002752|cell surface pattern recognition receptor signaling pathway;GO:0007186|G protein-coupled receptor signaling pathway;GO:0032757|positive regulation of interleukin-8 production;GO:0034394|protein localization to cell surface;GO:0043654|recognition of apoptotic cell;GO:0046597|negative regulation of viral entry into host cell;","GO:0005581|collagen trimer;GO:0005615|extracellular space;GO:0031232|extrinsic component of external side of plasma membrane;GO:0062023|collagen-containing extracellular matrix;","GO:0001664|G protein-coupled receptor binding;GO:0003823|antigen binding;GO:0005102|signaling receptor binding;GO:0030246|carbohydrate binding;GO:0033691|sialic acid binding;GO:0038187|pattern recognition receptor activity;GO:0046872|metal ion binding;GO:0097367|carbohydrate derivative binding;","K10104","FCN; ficolin"]
["ENSRNOG00000004249",286,24.06268683,46,2.959200157,8.13148336,3.023518555,{"v":3.21e-57,"d":"3.21E-57"},{"v":2.59e-56,"d":"2.59E-56"},"up","yes","ENSRNOG00000004249","protein_coding","chrX:27027425-27054754:+","gi|564398991|ref|XP_006256904.1|",4998,0,"PREDICTED: toll-like receptor 7 isoform X2 [Rattus norvegicus]","gi|672087353|ref|XM_008773170.1|",4113,0,"PREDICTED: Rattus norvegicus toll-like receptor 7 (Tlr7), transcript variant X2, mRNA","P58681",1778,0,"Toll-like receptor 7","MA2301_1",53.9,{"v":2e-06,"d":"2.00E-06"},"COG4886","pfam01582","TIR","TIR domain. The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.","GO:0000165|MAPK cascade;GO:0001932|regulation of protein phosphorylation;GO:0002224|toll-like receptor signaling pathway;GO:0002755|MyD88-dependent toll-like receptor signaling pathway;GO:0006954|inflammatory response;GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0007252|I-kappaB phosphorylation;GO:0007254|JNK cascade;GO:0032722|positive regulation of chemokine production;GO:0032727|positive regulation of interferon-alpha production;GO:0032728|positive regulation of interferon-beta production;GO:0032729|positive regulation of interferon-gamma production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0034154|toll-like receptor 7 signaling pathway;GO:0045087|innate immune response;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051607|defense response to virus;GO:0071260|cellular response to mechanical stimulus;GO:0098586|cellular response to virus;GO:1901224|positive regulation of NIK/NF-kappaB signaling;","GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0005768|endosome;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0032009|early phagosome;GO:0043235|receptor complex;","GO:0003725|double-stranded RNA binding;GO:0003727|single-stranded RNA binding;GO:0003953|NAD+ nucleosidase activity;GO:0004888|transmembrane signaling receptor activity;GO:0035197|siRNA binding;GO:0038187|pattern recognition receptor activity;","K05404","TLR7; toll-like receptor 7"]
["ENSRNOG00000056837",1181,99.36375227,747,48.05483732,2.067715922,1.048037991,{"v":2.49e-56,"d":"2.49E-56"},{"v":1.97e-55,"d":"1.97E-55"},"up","yes","Abr","protein_coding","chr10:61262516-61461505:-","gi|880872505|ref|XP_012967158.1|",5509,0,"PREDICTED: active breakpoint cluster region-related protein isoform X1 [Mesocricetus auratus]","gi|747019235|ref|NM_001105814.2|",4864,0,"Rattus norvegicus active BCR-related (Abr), mRNA","Q5SSL4",1727,0,"Active breakpoint cluster region-related protein",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0002692|negative regulation of cellular extravasation;GO:0007420|brain development;GO:0030036|actin cytoskeleton organization;GO:0030336|negative regulation of cell migration;GO:0032496|response to lipopolysaccharide;GO:0035556|intracellular signal transduction;GO:0042472|inner ear morphogenesis;GO:0043114|regulation of vascular permeability;GO:0043314|negative regulation of neutrophil degranulation;GO:0043547|positive regulation of GTPase activity;GO:0050728|negative regulation of inflammatory response;GO:0050766|positive regulation of phagocytosis;GO:0050804|modulation of chemical synaptic transmission;GO:0050885|neuromuscular process controlling balance;GO:0060313|negative regulation of blood vessel remodeling;GO:0090630|activation of GTPase activity;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0030424|axon;GO:0043197|dendritic spine;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098978|glutamatergic synapse;GO:0099092|postsynaptic density, intracellular component;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0005096|GTPase activator activity;GO:0005515|protein binding;","K20629","ABR; active breakpoint cluster region-related protein"]
["ENSRNOG00000069878",205,17.24773007,9,0.578973944,29.79016631,4.896764273,{"v":3.09e-56,"d":"3.09E-56"},{"v":2.44e-55,"d":"2.44E-55"},"up","yes","ENSRNOG00000069878","protein_coding","chr13:85977035-85994718:-","gi|755496152|ref|XP_011237197.1|",1914,0,"PREDICTED: LOW QUALITY PROTEIN: gamma-interferon-inducible protein 16-like [Mus musculus]","gi|298891459|emb|FQ227444.1|",950,0,"Rattus norvegicus TL0AEA13YF07 mRNA sequence","P0DOV2",353,{"v":1E-107,"d":"1.00E-107"},"Interferon-activable protein 204",".",".",".",".","pfam02760","HIN","HIN-200/IF120x domain. This domain has no know function. It is found in one or two copies per protein, and is found associated with the PAAD/DAPIN domain pfam02758.",".",".",".",".","."]
["ENSRNOG00000009360",1090,91.70744282,666,42.84407183,2.140493163,1.097943227,{"v":4.34e-56,"d":"4.34E-56"},{"v":3.43e-55,"d":"3.43E-55"},"up","yes","Sh3bp1","protein_coding","chr7:110457710-110470201:+","gi|285002227|ref|NP_001165452.1|",2903,0,"SH3 domain-binding protein 1 [Rattus norvegicus]","gi|285002226|ref|NM_001171981.1|",2407,0,"Rattus norvegicus SH3-domain binding protein 1 (Sh3bp1), mRNA","D3ZFJ3",1122,0,"SH3 domain-binding protein 1",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0006911|phagocytosis, engulfment;GO:0007015|actin filament organization;GO:0016477|cell migration;GO:0030834|regulation of actin filament depolymerization;GO:0032956|regulation of actin cytoskeleton organization;GO:0034329|cell junction assembly;GO:0035020|regulation of Rac protein signal transduction;GO:0043535|regulation of blood vessel endothelial cell migration;GO:0043547|positive regulation of GTPase activity;GO:0045198|establishment of epithelial cell apical/basal polarity;GO:0046847|filopodium assembly;GO:0051058|negative regulation of small GTPase mediated signal transduction;GO:0071526|semaphorin-plexin signaling pathway;GO:0097178|ruffle assembly;","GO:0001891|phagocytic cup;GO:0005622|intracellular;GO:0005634|nucleus;GO:0005829|cytosol;GO:0005912|adherens junction;GO:0005923|bicellular tight junction;GO:0030027|lamellipodium;GO:0031252|cell leading edge;","GO:0005096|GTPase activator activity;GO:0017124|SH3 domain binding;GO:0030215|semaphorin receptor binding;","K20652","SH3BP1, ARHGAP43; SH3-domain binding protein 1"]
["ENSRNOG00000057092",198,16.65878319,4,0.257321753,64.73911752,6.016565795,1.21E-55,{"v":9.48e-55,"d":"9.48E-55"},"up","yes","Slfn4","protein_coding","chr10:67994632-68018138:+","gi|16758506|ref|NP_446139.1|",3009,0,"schlafen 4 [Rattus norvegicus]","gi|672068330|ref|XM_008767933.1|",5279,0,"PREDICTED: Rattus norvegicus schlafen 3 (Slfn3), transcript variant X1, mRNA","Q8IYM2",446,{"v":1e-137,"d":"1.00E-137"},"Schlafen family member 12",".",".",".",".","pfam04326","AAA_4","Divergent AAA domain. This family is related to the pfam00004 family, and presumably has the same function (ATP-binding).","GO:0009617|response to bacterium;GO:0048286|lung alveolus development;","GO:0016021|integral component of membrane;",".","K24457","SLFN12, SLFN12L; schlafen family member 12"]
["ENSRNOG00000068984",200,16.82705373,3,0.192991315,87.19073067,6.446102864,1.35E-55,{"v":1.06e-54,"d":"1.06E-54"},"up","yes","Gbp1","protein_coding","chr2:231398163-231432131:+","gi|564301074|ref|XP_006224340.1|",3824,0,"PREDICTED: interferon-induced guanylate-binding protein 1 [Rattus norvegicus]","gi|672016387|ref|XM_006224278.2|",2616,0,"PREDICTED: Rattus norvegicus guanylate binding protein 1, interferon-inducible (Gbp1), transcript variant X1, mRNA","Q5D1D6",855,0,"Guanylate-binding protein 1",".",".",".",".","pfam02263","GBP","Guanylate-binding protein, N-terminal domain. Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.",".",".",".",".","."]
["ENSRNOG00000050974",228,19.18284125,21,1.350939202,14.19963328,3.827781766,2.19E-55,1.71E-54,"up","yes","AABR07030773.1","protein_coding","chr10:100253624-100258323:-","gi|269973887|ref|NP_001161756.1|",999,{"v":3E-134,"d":"3.00E-134"},"immune activating receptor CD300d2 precursor [Rattus norvegicus]","gi|269973886|ref|NM_001168284.1|",630,0,"Rattus norvegicus similar to dendritic cell-derived immunoglobulin(Ig)-like receptor 1, DIgR1 - mouse (RGD1561778), mRNA","Q7TSN2",251,{"v":2e-81,"d":"2.00E-81"},"CMRF35-like molecule",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000009331",337,28.35358553,78,5.017774178,5.650630045,2.498411737,{"v":2.73e-55,"d":"2.73E-55"},{"v":2.12e-54,"d":"2.12E-54"},"up","yes","Hck","protein_coding","chr3:141571587-141614693:+","gi|34734058|ref|NP_037317.2|",2793,0,"tyrosine-protein kinase HCK [Rattus norvegicus]","gi|319918868|ref|NM_013185.3|",2054,0,"Rattus norvegicus hemopoietic cell kinase (Hck), mRNA","P50545",1080,0,"Tyrosine-protein kinase HCK","YAR019c",109,{"v":7e-24,"d":"7.00E-24"},"COG0515","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0006887|exocytosis;GO:0006909|phagocytosis;GO:0006954|inflammatory response;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0008284|positive regulation of cell proliferation;GO:0008360|regulation of cell shape;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0030154|cell differentiation;GO:0043066|negative regulation of apoptotic process;GO:0045087|innate immune response;GO:0046777|protein autophosphorylation;GO:0050764|regulation of phagocytosis;GO:0050830|defense response to Gram-positive bacterium;GO:0051090|regulation of DNA-binding transcription factor activity;GO:0071801|regulation of podosome assembly;GO:2000251|positive regulation of actin cytoskeleton reorganization;","GO:0005634|nucleus;GO:0005764|lysosome;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0005901|caveola;GO:0005925|focal adhesion;GO:0030133|transport vesicle;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0042995|cell projection;GO:0043231|intracellular membrane-bounded organelle;","GO:0001784|phosphotyrosine residue binding;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0005102|signaling receptor binding;GO:0005524|ATP binding;","K08893","HCK; hemopoietic cell kinase [EC:2.7.10.2]"]
["ENSRNOG00000018570",196,16.49051265,5,0.321652191,51.26814963,5.679990924,{"v":3.52e-55,"d":"3.52E-55"},{"v":2.72e-54,"d":"2.72E-54"},"up","yes","C1qtnf3","protein_coding","chr2:59917188-59939433:+","gi|197313725|ref|NP_001127908.1|",1407,0,"complement C1q tumor necrosis factor-related protein 3 precursor [Rattus norvegicus]","gi|197313724|ref|NM_001134436.1|",1920,0,"Rattus norvegicus C1q and tumor necrosis factor related protein 3 (C1qtnf3), mRNA","Q9ES30",365,{"v":1e-120,"d":"1.00E-120"},"Complement C1q tumor necrosis factor-related protein 3",".",".",".",".","pfam00386","C1q","C1q domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.","GO:0001819|positive regulation of cytokine production;GO:0010629|negative regulation of gene expression;GO:0032715|negative regulation of interleukin-6 production;GO:0035356|cellular triglyceride homeostasis;GO:0042593|glucose homeostasis;GO:0045444|fat cell differentiation;GO:0045721|negative regulation of gluconeogenesis;GO:0050728|negative regulation of inflammatory response;GO:0051897|positive regulation of protein kinase B signaling;GO:0070165|positive regulation of adiponectin secretion;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071638|negative regulation of monocyte chemotactic protein-1 production;GO:1901223|negative regulation of NIK/NF-kappaB signaling;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0032991|protein-containing complex;","GO:0042802|identical protein binding;","K24236","C1QTNF3; complement C1q and tumor necrosis factor-related protein 3"]
["ENSRNOG00000016308",361,30.37283198,93,5.982730751,5.076750608,2.343905391,{"v":5.26e-55,"d":"5.26E-55"},{"v":4.06e-54,"d":"4.06E-54"},"up","yes","Il10ra","protein_coding","chr8:45563137-45578061:-","gi|340523096|ref|NP_476541.2|",2900,0,"interleukin-10 receptor subunit alpha precursor [Rattus norvegicus]","gi|672061584|ref|XM_006242864.2|",3339,0,"PREDICTED: Rattus norvegicus interleukin 10 receptor, alpha (Il10ra), transcript variant X1, mRNA","Q61727",885,0,"Interleukin-10 receptor subunit alpha",".",".",".",".","pfam01108","Tissue_fac","Tissue factor. This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.","GO:0010507|negative regulation of autophagy;GO:0019221|cytokine-mediated signaling pathway;GO:0032496|response to lipopolysaccharide;GO:0046427|positive regulation of JAK-STAT cascade;GO:0050807|regulation of synapse organization;GO:0070086|ubiquitin-dependent endocytosis;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004896|cytokine receptor activity;GO:0004920|interleukin-10 receptor activity;GO:0019969|interleukin-10 binding;","K05134","IL10RA, CD210A; interleukin 10 receptor alpha"]
["ENSRNOG00000006952",519,43.66620443,202,12.99474851,3.360296229,1.74858842,3.98E-54,3.03E-53,"up","yes","Prex1","protein_coding","chr3:155306950-155456688:-","gi|208973288|ref|NP_001129190.1|",8373,0,"phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [Rattus norvegicus]","gi|208973287|ref|NM_001135718.1|",5435,0,"Rattus norvegicus phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 (Prex1), mRNA","Q69ZK0",3115,0,"Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein",".",".",".",".","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0030217|T cell differentiation;GO:0030335|positive regulation of cell migration;GO:0030593|neutrophil chemotaxis;GO:0030833|regulation of actin filament polymerization;GO:0035556|intracellular signal transduction;GO:0043547|positive regulation of GTPase activity;GO:0045785|positive regulation of cell adhesion;GO:0050773|regulation of dendrite development;GO:0072593|reactive oxygen species metabolic process;GO:1900026|positive regulation of substrate adhesion-dependent cell spreading;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0030426|growth cone;GO:0043198|dendritic shaft;GO:0048471|perinuclear region of cytoplasm;","GO:0003674|molecular_function;GO:0005085|guanyl-nucleotide exchange factor activity;GO:0005543|phospholipid binding;","K12365","PREX1; phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchanger 1 protein"]
["ENSRNOG00000023993",654,55.02446569,305,19.62078365,2.804396944,1.487690568,{"v":4.79e-54,"d":"4.79E-54"},{"v":3.62e-53,"d":"3.62E-53"},"up","yes","Kif1a","protein_coding","chr9:93563045-93647480:-","gi|568908181|ref|XP_006529221.1|",8907,0,"PREDICTED: kinesin-like protein KIF1A isoform X5 [Mus musculus]","gi|755493818|ref|XM_006529158.2|",5209,0,"PREDICTED: Mus musculus kinesin family member 1A (Kif1a), transcript variant X4, mRNA","O60333",2387,0,"Kinesin-like protein KIF1B","SPAC1834.07",222,{"v":7e-60,"d":"7.00E-60"},"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0007018|microtubule-based movement;GO:0008089|anterograde axonal transport;GO:0016192|vesicle-mediated transport;GO:0022027|interkinetic nuclear migration;GO:0030705|cytoskeleton-dependent intracellular transport;GO:0060998|regulation of dendritic spine development;GO:0061001|regulation of dendritic spine morphogenesis;GO:0098840|protein transport along microtubule;GO:0099519|dense core granule cytoskeletal transport;GO:1990048|anterograde neuronal dense core vesicle transport;GO:1990049|retrograde neuronal dense core vesicle transport;","GO:0005829|cytosol;GO:0005871|kinesin complex;GO:0005874|microtubule;GO:0008021|synaptic vesicle;GO:0030424|axon;GO:0030425|dendrite;GO:0032991|protein-containing complex;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0048471|perinuclear region of cytoplasm;GO:0098674|extrinsic component of neuronal dense core vesicle membrane;GO:0098793|presynapse;GO:0098794|postsynapse;GO:0098992|neuronal dense core vesicle;GO:1904115|axon cytoplasm;","GO:0003777|microtubule motor activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0008017|microtubule binding;GO:0008574|ATP-dependent microtubule motor activity, plus-end-directed;GO:0016887|ATPase activity;GO:0042802|identical protein binding;","K10392","KIF1; kinesin family member 1"]
["ENSRNOG00000016728",1090,91.70744282,678,43.61603709,2.102608328,1.072180131,4.91E-54,{"v":3.71e-53,"d":"3.71E-53"},"up","yes","Tiam2","protein_coding","chr1:43918174-44119493:+","gi|564296319|ref|XP_006222963.1|",8575,0,"PREDICTED: T-lymphoma invasion and metastasis-inducing protein 2 isoform X1 [Rattus norvegicus]","gi|672012712|ref|XM_006222901.2|",5714,0,"PREDICTED: Rattus norvegicus T-cell lymphoma invasion and metastasis 2 (LOC100362710), transcript variant X1, mRNA","Q6ZPF3",3048,0,"T-lymphoma invasion and metastasis-inducing protein 2",".",".",".",".","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0007264|small GTPase mediated signal transduction;GO:0050772|positive regulation of axonogenesis;GO:0090630|activation of GTPase activity;","GO:0005737|cytoplasm;GO:0016020|membrane;GO:0045202|synapse;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0005096|GTPase activator activity;","K16847","TIAM2; T-lymphoma invasion and metastasis-inducing protein 2"]
["ENSRNOG00000053200",468,39.37530573,166,10.67885274,3.687222466,1.882534463,{"v":5.22e-54,"d":"5.22E-54"},{"v":3.93e-53,"d":"3.93E-53"},"up","yes","Dock10","protein_coding","chr9:81843604-82101525:-","gi|392342442|ref|XP_003754589.1|",11191,0,"PREDICTED: dedicator of cytokinesis protein 10 isoform X13 [Rattus norvegicus]","gi|672024204|ref|XM_003754541.3|",7709,0,"PREDICTED: Rattus norvegicus dedicator of cytokinesis 10 (Dock10), transcript variant X13, mRNA","Q8BZN6",4110,0,"Dedicator of cytokinesis protein 10",".",".",".",".","pfam06920","Ded_cyto","Dedicator of cytokinesis. This family represents a conserved region approximately 200 residues long within a number of eukaryotic dedicator of cytokinesis proteins. These are potential guanine nucleotide exchange factors, which activate some small GTPases by exchanging bound GDP for free GTP.","GO:0001782|B cell homeostasis;GO:0002315|marginal zone B cell differentiation;GO:0030334|regulation of cell migration;GO:0043547|positive regulation of GTPase activity;GO:0060997|dendritic spine morphogenesis;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0043197|dendritic spine;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0031267|small GTPase binding;","K21853","DOCK9_10_11; dedicator of cytokinesis protein 9/10/11"]
["ENSRNOG00000038881",418,35.16854229,132,8.49161784,4.141559707,2.050174187,{"v":5.53e-54,"d":"5.53E-54"},4.16E-53,"up","yes","Hcls1","protein_coding","chr11:63817476-63841014:-","gi|58865374|ref|NP_001011898.1|",1858,0,"hematopoietic lineage cell-specific protein [Rattus norvegicus]","gi|58865373|ref|NM_001011898.1|",1914,0,"Rattus norvegicus hematopoietic cell specific Lyn substrate 1 (Hcls1), mRNA","P49710",675,0,"Hematopoietic lineage cell-specific protein",".",".",".",".","pfam02218","HS1_rep","Repeat in HS1/Cortactin. The function of this repeat is unknown. Seven copies are found in cortactin and four copies are found in HS1. The repeats are always found amino terminal to an SH3 domain pfam00018.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0008284|positive regulation of cell proliferation;GO:0009725|response to hormone;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0030041|actin filament polymerization;GO:0030218|erythrocyte differentiation;GO:0030833|regulation of actin filament polymerization;GO:0030854|positive regulation of granulocyte differentiation;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0042307|positive regulation of protein import into nucleus;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0045651|positive regulation of macrophage differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051897|positive regulation of protein kinase B signaling;GO:0071345|cellular response to cytokine stimulus;GO:2000107|negative regulation of leukocyte apoptotic process;","GO:0005634|nucleus;GO:0005667|transcription factor complex;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0030427|site of polarized growth;GO:0030864|cortical actin cytoskeleton;","GO:0017124|SH3 domain binding;GO:0019901|protein kinase binding;GO:0044877|protein-containing complex binding;GO:0051015|actin filament binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;","K06106","CTTN, EMS1; cortactin"]
["ENSRNOG00000004444",225,18.93043545,22,1.41526964,13.37585073,3.741558747,{"v":7.39e-54,"d":"7.39E-54"},{"v":5.56e-53,"d":"5.56E-53"},"up","yes","Ikzf1","protein_coding","chr14:86255065-86342416:+","gi|672076803|ref|XP_008768537.1|",2281,0,"PREDICTED: DNA-binding protein Ikaros isoform X6 [Rattus norvegicus]","gi|672076802|ref|XM_008770315.1|",1830,0,"PREDICTED: Rattus norvegicus IKAROS family zinc finger 1 (Ikzf1), transcript variant X11, mRNA","Q03267",736,0,"DNA-binding protein Ikaros",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001779|natural killer cell differentiation;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0010628|positive regulation of gene expression;GO:0030097|hemopoiesis;GO:0030098|lymphocyte differentiation;GO:0030183|B cell differentiation;GO:0030217|T cell differentiation;GO:0030218|erythrocyte differentiation;GO:0030900|forebrain development;GO:0032968|positive regulation of transcription elongation from RNA polymerase II promoter;GO:0035881|amacrine cell differentiation;GO:0040018|positive regulation of multicellular organism growth;GO:0045184|establishment of protein localization;GO:0045660|positive regulation of neutrophil differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045899|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048535|lymph node development;GO:0048538|thymus development;GO:0048541|Peyer's patch development;GO:0048732|gland development;GO:0051138|positive regulation of NK T cell differentiation;GO:0060040|retinal bipolar neuron differentiation;GO:0060041|retina development in camera-type eye;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005721|pericentric heterochromatin;GO:0005829|cytosol;GO:0032991|protein-containing complex;GO:0032993|protein-DNA complex;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0008187|poly-pyrimidine tract binding;GO:0019904|protein domain specific binding;GO:0042802|identical protein binding;GO:0043565|sequence-specific DNA binding;","K09220","IKZF, ZNFN1A; IKAROS family zinc finger protein"]
["ENSRNOG00000001314",966,81.27466951,570,36.66834977,2.216480153,1.148270445,1.63E-53,1.22E-52,"up","yes","Fam20c","protein_coding","chr12:15826871-15884543:-","gi|59676599|ref|NP_001012238.1|",2766,0,"extracellular serine/threonine protein kinase FAM20C [Rattus norvegicus]","gi|59676598|ref|NM_001012238.1|",2658,0,"Rattus norvegicus family with sequence similarity 20, member C (Fam20c), mRNA","Q5MJS3",1043,0,"Extracellular serine/threonine protein kinase FAM20C",".",".",".",".","pfam06702","DUF1193","Protein of unknown function (DUF1193). This family represents the C-terminus of several hypothetical eukaryotic proteins of unknown function. Family members contain two conserved motifs: DRHHYE and QCC, as well as a number of conserved cysteine residues.","GO:0001501|skeletal system development;GO:0006468|protein phosphorylation;GO:0030501|positive regulation of bone mineralization;GO:0031214|biomineral tissue development;GO:0036179|osteoclast maturation;GO:0040036|regulation of fibroblast growth factor receptor signaling pathway;GO:0045669|positive regulation of osteoblast differentiation;GO:0046034|ATP metabolic process;GO:0051174|regulation of phosphorus metabolic process;GO:0070166|enamel mineralization;GO:0071895|odontoblast differentiation;GO:0097187|dentinogenesis;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;","GO:0004674|protein serine/threonine kinase activity;GO:0005509|calcium ion binding;GO:0016773|phosphotransferase activity, alcohol group as acceptor;GO:0030145|manganese ion binding;","K21958","FAM20C; extracellular serine/threonine protein kinase FAM20C [EC:2.7.11.1]"]
["ENSRNOG00000018646",474,39.88011734,173,11.12916581,3.583387833,1.841324196,{"v":4.08e-53,"d":"4.08E-53"},{"v":3.04e-52,"d":"3.04E-52"},"up","yes","Hbegf","protein_coding","chr18:28105760-28116441:-","gi|6978785|ref|NP_037077.1|",844,{"v":3e-104,"d":"3.00E-104"},"proheparin-binding EGF-like growth factor precursor [Rattus norvegicus]","gi|257196256|ref|NM_010415.2|",1685,0,"Mus musculus heparin-binding EGF-like growth factor (Hbegf), mRNA","Q06175",329,{"v":1e-105,"d":"1.00E-105"},"Proheparin-binding EGF-like growth factor",".",".",".",".","pfam00008","EGF","EGF-like domain. There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.","GO:0007173|epidermal growth factor receptor signaling pathway;GO:0007399|nervous system development;GO:0008016|regulation of heart contraction;GO:0008284|positive regulation of cell proliferation;GO:0016477|cell migration;GO:0030307|positive regulation of cell growth;GO:0030335|positive regulation of cell migration;GO:0035313|wound healing, spreading of epidermal cells;GO:0045741|positive regulation of epidermal growth factor-activated receptor activity;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0051545|negative regulation of elastin biosynthetic process;GO:0051549|positive regulation of keratinocyte migration;GO:0051897|positive regulation of protein kinase B signaling;GO:0060326|cell chemotaxis;GO:0090303|positive regulation of wound healing;","GO:0005615|extracellular space;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;","GO:0005154|epidermal growth factor receptor binding;GO:0008083|growth factor activity;GO:0008201|heparin binding;","K08523","HBEGF; heparin-binding EGF-like growth factor"]
["ENSRNOG00000021424",218,18.34148856,20,1.286608764,14.25568446,3.833465405,{"v":4.37e-53,"d":"4.37E-53"},3.25E-52,"up","yes","Cd300lf","protein_coding","chr10:100359943-100376041:-","gi|68341985|ref|NP_001020282.1|",1394,0,"CMRF35-like molecule 1 precursor [Rattus norvegicus]","gi|68341984|ref|NM_001025111.1|",1786,0,"Rattus norvegicus Cd300 molecule-like family member F (Cd300lf), mRNA","Q566E6",541,0,"CMRF35-like molecule 1",".",".",".",".","pfam15330","SIT","SHP2-interacting transmembrane adaptor protein, SIT. SIT, or SHP2-interacting transmembrane adaptor protein, is a disulfide-linked dimer that regulates human T Cell activation.","GO:0030316|osteoclast differentiation;GO:0033004|negative regulation of mast cell activation;GO:0034125|negative regulation of MyD88-dependent toll-like receptor signaling pathway;GO:0035666|TRIF-dependent toll-like receptor signaling pathway;GO:0035772|interleukin-13-mediated signaling pathway;GO:0046718|viral entry into host cell;GO:1902216|positive regulation of interleukin-4-mediated signaling pathway;GO:2000426|negative regulation of apoptotic cell clearance;GO:2000427|positive regulation of apoptotic cell clearance;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0001618|virus receptor activity;GO:0001786|phosphatidylserine binding;GO:0004888|transmembrane signaling receptor activity;GO:0005136|interleukin-4 receptor binding;GO:0042802|identical protein binding;GO:0097001|ceramide binding;","K20395","CD300B_D_F; CO300B/D/F antigen"]
["ENSRNOG00000012160",429,36.09403025,142,9.134922222,3.951213746,1.982295893,{"v":4.62e-53,"d":"4.62E-53"},{"v":3.43e-52,"d":"3.43E-52"},"up","yes","Syk","protein_coding","chr17:12604619-12661410:-","gi|149044986|gb|EDL98072.1|",3332,0,"spleen tyrosine kinase, isoform CRA_a [Rattus norvegicus]","gi|6981619|ref|NM_012758.1|",5188,0,"Rattus norvegicus spleen tyrosine kinase (Syk), mRNA","Q64725",1261,0,"Tyrosine-protein kinase SYK","Rv0015c",91.7,{"v":3e-18,"d":"3.00E-18"},"COG0515","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001525|angiogenesis;GO:0001775|cell activation;GO:0001819|positive regulation of cytokine production;GO:0001820|serotonin secretion;GO:0001945|lymph vessel development;GO:0002092|positive regulation of receptor internalization;GO:0002223|stimulatory C-type lectin receptor signaling pathway;GO:0002250|adaptive immune response;GO:0002281|macrophage activation involved in immune response;GO:0002283|neutrophil activation involved in immune response;GO:0002366|leukocyte activation involved in immune response;GO:0002554|serotonin secretion by platelet;GO:0006468|protein phosphorylation;GO:0006606|protein import into nucleus;GO:0007159|leukocyte cell-cell adhesion;GO:0007166|cell surface receptor signaling pathway;GO:0007167|enzyme linked receptor protein signaling pathway;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007229|integrin-mediated signaling pathway;GO:0010543|regulation of platelet activation;GO:0010803|regulation of tumor necrosis factor-mediated signaling pathway;GO:0018105|peptidyl-serine phosphorylation;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0019370|leukotriene biosynthetic process;GO:0030154|cell differentiation;GO:0030593|neutrophil chemotaxis;GO:0031334|positive regulation of protein complex assembly;GO:0031623|receptor internalization;GO:0032481|positive regulation of type I interferon production;GO:0032725|positive regulation of granulocyte macrophage colony-stimulating factor production;GO:0032733|positive regulation of interleukin-10 production;GO:0032735|positive regulation of interleukin-12 production;GO:0032752|positive regulation of interleukin-3 production;GO:0032753|positive regulation of interleukin-4 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032928|regulation of superoxide anion generation;GO:0032930|positive regulation of superoxide anion generation;GO:0033630|positive regulation of cell adhesion mediated by integrin;GO:0035556|intracellular signal transduction;GO:0038063|collagen-activated tyrosine kinase receptor signaling pathway;GO:0038156|interleukin-3-mediated signaling pathway;GO:0042742|defense response to bacterium;GO:0043280|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043306|positive regulation of mast cell degranulation;GO:0043313|regulation of neutrophil degranulation;GO:0043366|beta selection;GO:0043410|positive regulation of MAPK cascade;GO:0043507|positive regulation of JUN kinase activity;GO:0045087|innate immune response;GO:0045579|positive regulation of B cell differentiation;GO:0045588|positive regulation of gamma-delta T cell differentiation;GO:0045780|positive regulation of bone resorption;GO:0046638|positive regulation of alpha-beta T cell differentiation;GO:0046641|positive regulation of alpha-beta T cell proliferation;GO:0046777|protein autophosphorylation;GO:0048514|blood vessel morphogenesis;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050764|regulation of phagocytosis;GO:0050776|regulation of immune response;GO:0050850|positive regulation of calcium-mediated signaling;GO:0050853|B cell receptor signaling pathway;GO:0051090|regulation of DNA-binding transcription factor activity;GO:0051712|positive regulation of killing of cells of other organism;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:0071226|cellular response to molecule of fungal origin;GO:0071396|cellular response to lipid;GO:0071404|cellular response to low-density lipoprotein particle stimulus;GO:0071639|positive regulation of monocyte chemotactic protein-1 production;GO:0090237|regulation of arachidonic acid secretion;GO:0090330|regulation of platelet aggregation;GO:0120162|positive regulation of cold-induced thermogenesis;GO:1900086|positive regulation of peptidyl-tyrosine autophosphorylation;GO:1990858|cellular response to lectin;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0019815|B cell receptor complex;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0032009|early phagosome;GO:0032991|protein-containing complex;GO:0042101|T cell receptor complex;","GO:0001784|phosphotyrosine residue binding;GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0005102|signaling receptor binding;GO:0005178|integrin binding;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0016170|interleukin-15 receptor binding;GO:0019901|protein kinase binding;GO:0019902|phosphatase binding;GO:0019904|protein domain specific binding;GO:0031625|ubiquitin protein ligase binding;GO:0035325|Toll-like receptor binding;GO:0042169|SH2 domain binding;GO:0043274|phospholipase binding;GO:0097110|scaffold protein binding;","K05855","SYK; spleen tyrosine kinase [EC:2.7.10.2]"]
["ENSRNOG00000011471",273,22.96892834,47,3.023530595,7.5967243,2.925377464,{"v":4.91e-53,"d":"4.91E-53"},{"v":3.64e-52,"d":"3.64E-52"},"up","yes","Fgf9","protein_coding","chr15:32210074-32253309:+","gi|74177316|dbj|BAE34566.1|",611,{"v":5e-84,"d":"5.00E-84"},"unnamed protein product [Mus musculus]","gi|755547794|ref|XM_006518554.2|",1348,0,"PREDICTED: Mus musculus fibroblast growth factor 9 (Fgf9), transcript variant X2, mRNA","P36364",240,{"v":9e-71,"d":"9.00E-71"},"Fibroblast growth factor 9",".",".",".",".","pfam00167","FGF","Fibroblast growth factor. Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide range of contexts. They are found in a wide range of organisms, from nematodes to humans. Most share an internal core region of high similarity, conserved residues in which are involved in binding with their receptors. On binding, they cause dimerization of their tyrosine kinase receptors leading to intracellular signalling. There are currently four known tyrosine kinase receptors for fibroblast growth factors. These receptors can each bind several different members of this family. Members of this family have a beta trefoil structure. Most have N-terminal signal peptides and are secreted. A few lack signal sequences but are secreted anyway; still others also lack the signal peptide but are found on the cell surface and within the extracellular matrix. A third group remain intracellular. They have central roles in development, regulating cell proliferation, migration and differentiation. On the other hand, they are important in tissue repair following injury in adult organisms.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001525|angiogenesis;GO:0001649|osteoblast differentiation;GO:0001654|eye development;GO:0001934|positive regulation of protein phosphorylation;GO:0002053|positive regulation of mesenchymal cell proliferation;GO:0002062|chondrocyte differentiation;GO:0006606|protein import into nucleus;GO:0007267|cell-cell signaling;GO:0008284|positive regulation of cell proliferation;GO:0008543|fibroblast growth factor receptor signaling pathway;GO:0008584|male gonad development;GO:0009887|animal organ morphogenesis;GO:0010628|positive regulation of gene expression;GO:0021762|substantia nigra development;GO:0030154|cell differentiation;GO:0030178|negative regulation of Wnt signaling pathway;GO:0030238|male sex determination;GO:0030324|lung development;GO:0030326|embryonic limb morphogenesis;GO:0030334|regulation of cell migration;GO:0030949|positive regulation of vascular endothelial growth factor receptor signaling pathway;GO:0032927|positive regulation of activin receptor signaling pathway;GO:0042472|inner ear morphogenesis;GO:0043410|positive regulation of MAPK cascade;GO:0045880|positive regulation of smoothened signaling pathway;GO:0048505|regulation of timing of cell differentiation;GO:0048566|embryonic digestive tract development;GO:0048706|embryonic skeletal system development;GO:0050679|positive regulation of epithelial cell proliferation;GO:0051781|positive regulation of cell division;GO:0060045|positive regulation of cardiac muscle cell proliferation;GO:0060484|lung-associated mesenchyme development;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:1904707|positive regulation of vascular smooth muscle cell proliferation;GO:1904754|positive regulation of vascular associated smooth muscle cell migration;GO:1905931|negative regulation of vascular smooth muscle cell differentiation involved in phenotypic switching;","GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0005737|cytoplasm;","GO:0005104|fibroblast growth factor receptor binding;GO:0008083|growth factor activity;GO:0008201|heparin binding;","K04358","FGF; fibroblast growth factor"]
["ENSRNOG00000013578",399,33.56997219,124,7.976974335,4.208359057,2.073257801,2.47E-52,{"v":1.81e-51,"d":"1.81E-51"},"up","yes","Trem2","protein_coding","chr9:12647259-12654170:-","gi|564367094|ref|XP_006244487.1|",987,{"v":2e-129,"d":"2.00E-129"},"PREDICTED: triggering receptor expressed on myeloid cells 2 isoform X2 [Rattus norvegicus]","gi|672064257|ref|XM_006244425.2|",982,0,"PREDICTED: Rattus norvegicus triggering receptor expressed on myeloid cells 2 (Trem2), transcript variant X2, mRNA","Q99NH8",322,{"v":2e-106,"d":"2.00E-106"},"Triggering receptor expressed on myeloid cells 2",".",".",".",".","pfam07223","DUF1421","Protein of unknown function (DUF1421). This family represents a conserved region approximately 350 residues long within a number of plant proteins of unknown function.","GO:0001774|microglial cell activation;GO:0001934|positive regulation of protein phosphorylation;GO:0002282|microglial cell activation involved in immune response;GO:0002588|positive regulation of antigen processing and presentation of peptide antigen via MHC class II;GO:0002862|negative regulation of inflammatory response to antigenic stimulus;GO:0002931|response to ischemia;GO:0006910|phagocytosis, recognition;GO:0006911|phagocytosis, engulfment;GO:0007613|memory;GO:0010468|regulation of gene expression;GO:0010507|negative regulation of autophagy;GO:0010628|positive regulation of gene expression;GO:0010822|positive regulation of mitochondrion organization;GO:0010875|positive regulation of cholesterol efflux;GO:0010887|negative regulation of cholesterol storage;GO:0010891|negative regulation of sequestering of triglyceride;GO:0010983|positive regulation of high-density lipoprotein particle clearance;GO:0014067|negative regulation of phosphatidylinositol 3-kinase signaling;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0019216|regulation of lipid metabolic process;GO:0030316|osteoclast differentiation;GO:0032006|regulation of TOR signaling;GO:0032008|positive regulation of TOR signaling;GO:0032497|detection of lipopolysaccharide;GO:0032499|detection of peptidoglycan;GO:0032675|regulation of interleukin-6 production;GO:0032691|negative regulation of interleukin-1 beta production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032733|positive regulation of interleukin-10 production;GO:0033674|positive regulation of kinase activity;GO:0034136|negative regulation of toll-like receptor 2 signaling pathway;GO:0034144|negative regulation of toll-like receptor 4 signaling pathway;GO:0034151|regulation of toll-like receptor 6 signaling pathway;GO:0034241|positive regulation of macrophage fusion;GO:0034351|negative regulation of glial cell apoptotic process;GO:0035176|social behavior;GO:0038160|CXCL12-activated CXCR4 signaling pathway;GO:0042742|defense response to bacterium;GO:0043066|negative regulation of apoptotic process;GO:0043124|negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043277|apoptotic cell clearance;GO:0045088|regulation of innate immune response;GO:0045672|positive regulation of osteoclast differentiation;GO:0045728|respiratory burst after phagocytosis;GO:0045960|positive regulation of complement activation, classical pathway;GO:0048143|astrocyte activation;GO:0048678|response to axon injury;GO:0050714|positive regulation of protein secretion;GO:0050730|regulation of peptidyl-tyrosine phosphorylation;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050766|positive regulation of phagocytosis;GO:0050829|defense response to Gram-negative bacterium;GO:0050850|positive regulation of calcium-mediated signaling;GO:0050866|negative regulation of cell activation;GO:0050921|positive regulation of chemotaxis;GO:0055088|lipid homeostasis;GO:0060075|regulation of resting membrane potential;GO:0060100|positive regulation of phagocytosis, engulfment;GO:0061518|microglial cell proliferation;GO:0061889|negative regulation of astrocyte activation;GO:0070269|pyroptosis;GO:0070345|negative regulation of fat cell proliferation;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070392|detection of lipoteichoic acid;GO:0071223|cellular response to lipoteichoic acid;GO:0071224|cellular response to peptidoglycan;GO:0071333|cellular response to glucose stimulus;GO:0071396|cellular response to lipid;GO:0071456|cellular response to hypoxia;GO:0071640|regulation of macrophage inflammatory protein 1 alpha production;GO:0097028|dendritic cell differentiation;GO:0097062|dendritic spine maintenance;GO:0097242|amyloid-beta clearance;GO:0098657|import into cell;GO:0110089|regulation of hippocampal neuron apoptotic process;GO:0120035|regulation of plasma membrane bounded cell projection organization;GO:0140052|cellular response to oxidised low-density lipoprotein particle stimulus;GO:0150062|complement-mediated synapse pruning;GO:0150076|neuroinflammatory response;GO:0150078|positive regulation of neuroinflammatory response;GO:0150079|negative regulation of neuroinflammatory response;GO:0150094|amyloid-beta clearance by cellular catabolic process;GO:1900015|regulation of cytokine production involved in inflammatory response;GO:1900016|negative regulation of cytokine production involved in inflammatory response;GO:1900223|positive regulation of amyloid-beta clearance;GO:1900226|negative regulation of NLRP3 inflammasome complex assembly;GO:1901076|positive regulation of engulfment of apoptotic cell;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1901800|positive regulation of proteasomal protein catabolic process;GO:1901980|positive regulation of inward rectifier potassium channel activity;GO:1902227|negative regulation of macrophage colony-stimulating factor signaling pathway;GO:1902531|regulation of intracellular signal transduction;GO:1903078|positive regulation of protein localization to plasma membrane;GO:1903082|positive regulation of C-C chemokine receptor CCR7 signaling pathway;GO:1903376|regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway;GO:1903753|negative regulation of p38MAPK cascade;GO:1903980|positive regulation of microglial cell activation;GO:1904093|negative regulation of autophagic cell death;GO:1904141|positive regulation of microglial cell migration;GO:1904646|cellular response to amyloid-beta;GO:1904951|positive regulation of establishment of protein localization;GO:1905291|positive regulation of CAMKK-AMPK signaling cascade;GO:1905581|positive regulation of low-density lipoprotein particle clearance;GO:1905805|excitatory synapse pruning;GO:1905808|positive regulation of synapse pruning;GO:1905907|negative regulation of amyloid fibril formation;GO:2000350|positive regulation of CD40 signaling pathway;GO:2001171|positive regulation of ATP biosynthetic process;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;GO:0031226|intrinsic component of plasma membrane;GO:0044853|plasma membrane raft;","GO:0001530|lipopolysaccharide binding;GO:0001540|amyloid-beta binding;GO:0001786|phosphatidylserine binding;GO:0004888|transmembrane signaling receptor activity;GO:0005543|phospholipid binding;GO:0008035|high-density lipoprotein particle binding;GO:0008429|phosphatidylethanolamine binding;GO:0019209|kinase activator activity;GO:0030169|low-density lipoprotein particle binding;GO:0034185|apolipoprotein binding;GO:0034186|apolipoprotein A-I binding;GO:0034189|very-low-density lipoprotein particle binding;GO:0038023|signaling receptor activity;GO:0042834|peptidoglycan binding;GO:0044877|protein-containing complex binding;GO:0070891|lipoteichoic acid binding;GO:0071813|lipoprotein particle binding;GO:0097110|scaffold protein binding;GO:0120146|sulfatide binding;GO:1990782|protein tyrosine kinase binding;","K14378","TREM2; triggering receptor expressed on myeloid cells 2"]
["ENSRNOG00000019440",251,21.11795243,37,2.380226213,8.872245972,3.149299363,{"v":2.56e-52,"d":"2.56E-52"},1.87E-51,"up","yes","Kcnn4","protein_coding","chr1:79959322-79974340:+","gi|397739060|ref|NP_075410.2|",1884,0,"intermediate conductance calcium-activated potassium channel protein 4 isoform a [Rattus norvegicus]","gi|397739059|ref|NM_023021.2|",1924,0,"Rattus norvegicus potassium calcium-activated channel subfamily N member 4 (Kcnn4), transcript variant 1, mRNA","O89109",709,0,"Intermediate conductance calcium-activated potassium channel protein 4",".",".",".",".","pfam03530","SK_channel","Calcium-activated SK potassium channel.","GO:0002376|immune system process;GO:0006811|ion transport;GO:0006813|potassium ion transport;GO:0006816|calcium ion transport;GO:0006820|anion transport;GO:0006884|cell volume homeostasis;GO:0030322|stabilization of membrane potential;GO:0045332|phospholipid translocation;GO:0046541|saliva secretion;GO:0050714|positive regulation of protein secretion;GO:0050862|positive regulation of T cell receptor signaling pathway;GO:0071805|potassium ion transmembrane transport;GO:0097623|potassium ion export across plasma membrane;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0031982|vesicle;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0045121|membrane raft;","GO:0005267|potassium channel activity;GO:0005516|calmodulin binding;GO:0015269|calcium-activated potassium channel activity;GO:0016286|small conductance calcium-activated potassium channel activity;GO:0019903|protein phosphatase binding;GO:0022894|Intermediate conductance calcium-activated potassium channel activity;","K04945","KCNN4, KCA3.1; potassium intermediate/small conductance calcium-activated channel subfamily N member 4"]
["ENSRNOG00000021199",460,38.70222358,166,10.67885274,3.624193022,1.857659794,{"v":3.35e-52,"d":"3.35E-52"},2.44E-51,"up","yes","Fcgr1a","protein_coding","chr2:183851077-183859994:-","gi|158631264|ref|NP_001094306.1|",1822,0,"high affinity immunoglobulin gamma Fc receptor I precursor [Rattus norvegicus]","gi|165971690|gb|BC158809.1|",1249,0,"Rattus norvegicus Fc fragment of IgG, high affinity Ia, receptor (CD64), mRNA (cDNA clone MGC:188236 IMAGE:7364883), complete cds","P26151",615,0,"High affinity immunoglobulin gamma Fc receptor I",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0001788|antibody-dependent cellular cytotoxicity;GO:0001798|positive regulation of type IIa hypersensitivity;GO:0001805|positive regulation of type III hypersensitivity;GO:0006898|receptor-mediated endocytosis;GO:0006910|phagocytosis, recognition;GO:0006911|phagocytosis, engulfment;GO:0007166|cell surface receptor signaling pathway;GO:0009617|response to bacterium;GO:0019884|antigen processing and presentation of exogenous antigen;GO:0032355|response to estradiol;GO:0038094|Fc-gamma receptor signaling pathway;GO:0042590|antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:0042742|defense response to bacterium;GO:0050766|positive regulation of phagocytosis;GO:0050776|regulation of immune response;GO:0060100|positive regulation of phagocytosis, engulfment;GO:0061098|positive regulation of protein tyrosine kinase activity;GO:0071871|response to epinephrine;GO:1904058|positive regulation of sensory perception of pain;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0045121|membrane raft;","GO:0004888|transmembrane signaling receptor activity;GO:0005515|protein binding;GO:0019770|IgG receptor activity;GO:0019864|IgG binding;GO:0031774|leukotriene receptor binding;","K06498","FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I"]
["ENSRNOG00000049282",189,15.90156577,8,0.514643505,30.89821518,4.949451599,{"v":3.81e-52,"d":"3.81E-52"},{"v":2.77e-51,"d":"2.77E-51"},"up","yes","Oas2","protein_coding","chr12:35806759-35829371:+","gi|57527617|ref|NP_001009715.1|",3782,0,"2'-5'-oligoadenylate synthase 2 [Rattus norvegicus]","gi|37921529|gb|AY230746.1|",2308,0,"Rattus norvegicus 2'-5' oligoadenylate synthetase 2 (Oas2) mRNA, complete cds","Q5MYU0",1461,0,"2'-5'-oligoadenylate synthase 2",".",".",".",".","pfam10421","OAS1_C","2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus. This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between 320 and 344 at the extreme C-terminal end. Oligoadenylate synthetases are antiviral enzymes that counteract vial attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesize 2'.5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication. This domain is often associated with NTP_transf_2 pfam01909.","GO:0006401|RNA catabolic process;GO:0009615|response to virus;GO:0009617|response to bacterium;GO:0032728|positive regulation of interferon-beta production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0042742|defense response to bacterium;GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0051607|defense response to virus;GO:0060337|type I interferon signaling pathway;GO:0060700|regulation of ribonuclease activity;GO:0070106|interleukin-27-mediated signaling pathway;GO:1903487|regulation of lactation;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016020|membrane;GO:0048471|perinuclear region of cytoplasm;","GO:0001730|2'-5'-oligoadenylate synthetase activity;GO:0003725|double-stranded RNA binding;GO:0005524|ATP binding;GO:0046872|metal ion binding;","K14216","OAS; 2'-5'-oligoadenylate synthetase [EC:2.7.7.84]"]
["ENSRNOG00000020699",364,30.62523779,102,6.561704695,4.667268524,2.222578473,{"v":4.15e-52,"d":"4.15E-52"},{"v":3.01e-51,"d":"3.01E-51"},"up","yes","Cd37","protein_coding","chr1:95719190-95724648:-","gi|74212826|dbj|BAE33374.1|",923,{"v":3e-117,"d":"3.00E-117"},"unnamed protein product [Mus musculus]","gi|74212825|dbj|AK155663.1|",897,0,"Mus musculus B6-derived CD11 +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F730112L14 product:CD37 antigen, full insert sequence","P31053",348,{"v":1e-113,"d":"1.00E-113"},"Leukocyte antigen CD37",".",".",".",".","pfam00335","Tetraspannin","Tetraspanin family.","GO:0002639|positive regulation of immunoglobulin production;GO:0002920|regulation of humoral immune response;GO:0008285|negative regulation of cell proliferation;GO:0030886|negative regulation of myeloid dendritic cell activation;GO:0042832|defense response to protozoan;GO:0050688|regulation of defense response to virus;","GO:0001772|immunological synapse;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;",".","K06475","CD37, TSPAN26; CD37 antigen"]
["ENSRNOG00000064635",495,41.64695798,192,12.35144413,3.371829038,1.753531389,6.66E-52,{"v":4.82e-51,"d":"4.82E-51"},"up","yes","Ly49si2","protein_coding","chr4:163514541-163751214:-","gi|57222324|ref|NP_001009498.1|",1439,0,"immunoreceptor Ly49si2 [Rattus norvegicus]","gi|672051472|ref|XM_006237116.2|",1128,0,"PREDICTED: Rattus norvegicus immunoreceptor Ly49si3 (Ly49si3), transcript variant X2, mRNA","Q60652",316,{"v":2E-100,"d":"2.00E-100"},"Killer cell lectin-like receptor 5",".",".",".",".","pfam08391","Ly49","Ly49-like protein, N-terminal region. The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).",".",".",".",".","."]
["ENSRNOG00000006963",283,23.81028103,56,3.602504538,6.60936878,2.724512495,{"v":3.44e-51,"d":"3.44E-51"},{"v":2.46e-50,"d":"2.46E-50"},"up","yes","Ctse","protein_coding","chr13:43092128-43114502:+","gi|564380459|ref|XP_006249810.1|",2063,0,"PREDICTED: cathepsin E isoform X1 [Rattus norvegicus]","gi|672073643|ref|XM_006249748.2|",1940,0,"PREDICTED: Rattus norvegicus cathepsin E (Ctse), transcript variant X1, mRNA","P16228",798,0,"Cathepsin E",".",".",".",".","pfam00026","Asp","Eukaryotic aspartyl protease. Aspartyl (acid) proteases include pepsins, cathepsins, and renins. Two-domain structure, probably arising from ancestral duplication. This family does not include the retroviral nor retrotransposon proteases (pfam00077), which are much smaller and appear to be homologous to a single domain of the eukaryotic asp proteases.","GO:0006508|proteolysis;GO:0016540|protein autoprocessing;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;","GO:0005768|endosome;","GO:0004190|aspartic-type endopeptidase activity;GO:0008233|peptidase activity;GO:0042802|identical protein binding;","K01382","CTSE; cathepsin E [EC:3.4.23.34]"]
["ENSRNOG00000059540",239,20.10832921,33,2.12290446,9.472083923,3.243681863,3.47E-51,{"v":2.48e-50,"d":"2.48E-50"},"up","yes","Gcnt3","protein_coding","chr8:70686844-70699562:-","gi|149028853|gb|EDL84194.1|",2443,0,"glucosaminyl (N-acetyl) transferase 3, mucin type, isoform CRA_b [Rattus norvegicus]","gi|672061866|ref|XM_008766220.1|",1802,0,"PREDICTED: Rattus norvegicus glucosaminyl (N-acetyl) transferase 3, mucin type (Gcnt3), transcript variant X2, mRNA","Q8CH87",921,0,"Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3",".",".",".",".","pfam02485","Branch","Core-2/I-Branching enzyme. This is a family of two different beta-1,6-N-acetylglucosaminyltransferase enzymes, I-branching enzyme and core-2 branching enzyme. I-branching enzyme is responsible for the production of the blood group I-antigen during embryonic development. Core-2 branching enzyme forms crucial side-chain branches in O-glycans.","GO:0006486|protein glycosylation;GO:0048729|tissue morphogenesis;GO:0050892|intestinal absorption;GO:0060993|kidney morphogenesis;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0003829|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity;GO:0008109|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity;GO:0008375|acetylglucosaminyltransferase activity;GO:0047225|acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity;","K09662","GCNT3; N-acetylglucosaminyltransferase 3, mucin type [EC:2.4.1.-]"]
["ENSRNOG00000057557",1078,90.6978196,685,44.06635016,2.058210387,1.04139046,{"v":4.66e-51,"d":"4.66E-51"},{"v":3.31e-50,"d":"3.31E-50"},"up","yes","Prlr","protein_coding","chr2:59134588-59324718:+","gi|2506457|sp|P05710.2|PRLR_RAT",3080,0,"RecName: Full=Prolactin receptor; Short=PRL-R; AltName: Full=Lactogen receptor; Flags: Precursor","gi|77627968|ref|NM_001034111.1|",2120,0,"Rattus norvegicus prolactin receptor (Prlr), transcript variant 1, mRNA","P05710",1191,0,"Prolactin receptor",".",".",".",".","pfam09067","EpoR_lig-bind","Erythropoietin receptor, ligand binding. Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.","GO:0007171|activation of transmembrane receptor protein tyrosine kinase activity;GO:0007259|JAK-STAT cascade;GO:0007595|lactation;GO:0008284|positive regulation of cell proliferation;GO:0009617|response to bacterium;GO:0019221|cytokine-mediated signaling pathway;GO:0030155|regulation of cell adhesion;GO:0030856|regulation of epithelial cell differentiation;GO:0038161|prolactin signaling pathway;GO:0038165|oncostatin-M-mediated signaling pathway;GO:0042976|activation of Janus kinase activity;GO:0043066|negative regulation of apoptotic process;GO:0048861|leukemia inhibitory factor signaling pathway;GO:0060644|mammary gland epithelial cell differentiation;GO:0060736|prostate gland growth;GO:0060749|mammary gland alveolus development;GO:0061180|mammary gland epithelium development;GO:0120162|positive regulation of cold-induced thermogenesis;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0043235|receptor complex;","GO:0004896|cytokine receptor activity;GO:0004923|leukemia inhibitory factor receptor activity;GO:0004924|oncostatin-M receptor activity;GO:0004925|prolactin receptor activity;GO:0005127|ciliary neurotrophic factor receptor binding;GO:0017046|peptide hormone binding;GO:0019901|protein kinase binding;GO:0019955|cytokine binding;GO:0046872|metal ion binding;","K05081","PRLR; prolactin receptor"]
["ENSRNOG00000049491",640,53.84657193,308,19.81377496,2.717633164,1.442350729,1.28E-50,{"v":9.02e-50,"d":"9.02E-50"},"up","yes","RT1-DMb","protein_coding","chr20:4693103-4700340:-","gi|258613997|ref|NP_942035.2|",1248,{"v":1E-168,"d":"1.00E-168"},"RT1 class II, DM beta precursor [Rattus norvegicus]","gi|672085842|ref|XM_003751925.3|",1292,0,"PREDICTED: Rattus norvegicus class II histocompatibility antigen, M beta 1 chain-like (LOC100909630), mRNA","P35737",421,{"v":6e-145,"d":"6.00E-145"},"Class II histocompatibility antigen, M beta 1 chain",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.","GO:0002250|adaptive immune response;GO:0002399|MHC class II protein complex assembly;GO:0002503|peptide antigen assembly with MHC class II protein complex;GO:0019882|antigen processing and presentation;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0042102|positive regulation of T cell proliferation;GO:0051085|chaperone cofactor-dependent protein refolding;GO:2001190|positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;","GO:0005764|lysosome;GO:0005765|lysosomal membrane;GO:0005770|late endosome;GO:0005771|multivesicular body;GO:0010008|endosome membrane;GO:0016021|integral component of membrane;GO:0031902|late endosome membrane;GO:0042613|MHC class II protein complex;GO:0043231|intracellular membrane-bounded organelle;","GO:0023026|MHC class II protein complex binding;","K06752","MHC2; MHC class II antigen"]
["ENSRNOG00000007679",539,45.3489098,230,14.79600078,3.064943728,1.615860587,2.17E-50,1.53E-49,"up","yes","Cyth4","protein_coding","chr7:110152272-110176741:+","gi|564361059|ref|XP_006242093.1|",2110,0,"PREDICTED: cytohesin-4 isoform X1 [Rattus norvegicus]","gi|672060229|ref|XM_006242031.2|",2681,0,"PREDICTED: Rattus norvegicus cytohesin 4 (Cyth4), transcript variant X1, mRNA","Q80YW0",791,0,"Cytohesin-4","SPAC30.01c",167,{"v":2E-41,"d":"2.00E-41"},"COG5307","pfam01369","Sec7","Sec7 domain. The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.","GO:0032012|regulation of ARF protein signal transduction;GO:0050790|regulation of catalytic activity;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0034451|centriolar satellite;GO:0045171|intercellular bridge;","GO:0005085|guanyl-nucleotide exchange factor activity;","K18441","CYTH; cytohesin"]
["ENSRNOG00000006227",539,45.3489098,231,14.86033122,3.051675574,1.609601596,{"v":4.05e-50,"d":"4.05E-50"},{"v":2.84e-49,"d":"2.84E-49"},"up","yes","Ifih1","protein_coding","chr3:47227364-47275456:-","gi|157822253|ref|NP_001102669.1|",5320,0,"interferon-induced helicase C domain-containing protein 1 [Rattus norvegicus]","gi|157822252|ref|NM_001109199.1|",3897,0,"Rattus norvegicus interferon induced with helicase C domain 1 (Ifih1), mRNA","Q8R5F7",1915,0,"Interferon-induced helicase C domain-containing protein 1","PH1896m_1",84,{"v":2e-15,"d":"2.00E-15"},"COG1111","pfam11648","RIG-I_C-RD","C-terminal domain of RIG-I. This family of proteins represents the regulatory domain RD of RIG-I, a protein which initiates a signalling cascade that provides essential antiviral protection for the host. The RD domain binds viral RNA, activating the RIG-I ATPase by RNA-dependant dimerization. The structure of RD contains a zinc-binding domain and is thought to confer ligand specificity.","GO:0009615|response to virus;GO:0016925|protein sumoylation;GO:0032727|positive regulation of interferon-alpha production;GO:0032728|positive regulation of interferon-beta production;GO:0032755|positive regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0039530|MDA-5 signaling pathway;GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0051607|defense response to virus;GO:0060760|positive regulation of response to cytokine stimulus;GO:0071360|cellular response to exogenous dsRNA;GO:0098586|cellular response to virus;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;","GO:0003677|DNA binding;GO:0003723|RNA binding;GO:0003724|RNA helicase activity;GO:0003725|double-stranded RNA binding;GO:0003727|single-stranded RNA binding;GO:0005524|ATP binding;GO:0008270|zinc ion binding;GO:0042802|identical protein binding;GO:0043021|ribonucleoprotein complex binding;","K12647","IFIH1, MDA5; interferon-induced helicase C domain-containing protein 1 [EC:3.6.4.13]"]
["ENSRNOG00000009912",245,20.61314082,38,2.444556651,8.432261453,3.0759196,{"v":4.75e-50,"d":"4.75E-50"},{"v":3.31e-49,"d":"3.31E-49"},"up","yes","Fgr","protein_coding","chr5:145189841-145217326:+","gi|564353313|ref|XP_006239140.1|",2763,0,"PREDICTED: tyrosine-protein kinase Fgr isoform X2 [Rattus norvegicus]","gi|40254760|ref|NM_024145.2|",2480,0,"Rattus norvegicus FGR proto-oncogene, Src family tyrosine kinase (Fgr), mRNA","Q6P6U0",1056,0,"Tyrosine-protein kinase Fgr","BH2504_1",98.2,{"v":4e-21,"d":"4.00E-21"},"COG0515","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001819|positive regulation of cytokine production;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007229|integrin-mediated signaling pathway;GO:0008150|biological_process;GO:0008360|regulation of cell shape;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0030154|cell differentiation;GO:0030282|bone mineralization;GO:0030335|positive regulation of cell migration;GO:0032815|negative regulation of natural killer cell activation;GO:0043306|positive regulation of mast cell degranulation;GO:0043552|positive regulation of phosphatidylinositol 3-kinase activity;GO:0045087|innate immune response;GO:0045088|regulation of innate immune response;GO:0045859|regulation of protein kinase activity;GO:0046777|protein autophosphorylation;GO:0048705|skeletal system morphogenesis;GO:0050764|regulation of phagocytosis;GO:0050830|defense response to Gram-positive bacterium;","GO:0005743|mitochondrial inner membrane;GO:0005758|mitochondrial intermembrane space;GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0015629|actin cytoskeleton;GO:0016235|aggresome;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0032587|ruffle membrane;","GO:0001784|phosphotyrosine residue binding;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0005102|signaling receptor binding;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0019901|protein kinase binding;GO:0034987|immunoglobulin receptor binding;GO:0034988|Fc-gamma receptor I complex binding;","K08891","FGR, SRC2; tyrosine-protein kinase Fgr [EC:2.7.10.2]"]
["ENSRNOG00000012508",829,69.74813771,469,30.17097551,2.311762763,1.208993354,{"v":5.67e-50,"d":"5.67E-50"},{"v":3.95e-49,"d":"3.95E-49"},"up","yes","Slc39a8","protein_coding","chr2:224256654-224319129:+","gi|58865482|ref|NP_001011952.1|",2351,0,"zinc transporter ZIP8 precursor [Rattus norvegicus]","gi|58865481|ref|NM_001011952.1|",3071,0,"Rattus norvegicus solute carrier family 39 member 8 (Slc39a8), mRNA","Q5FVQ0",910,0,"Zinc transporter ZIP8","RSc2227",84.3,{"v":1e-16,"d":"1.00E-16"},"COG0428","pfam02535","Zip","ZIP Zinc transporter. The ZIP family consists of zinc transport proteins and many putative metal transporters. The main contribution to this family is from the Arabidopsis thaliana ZIP protein family these proteins are responsible for zinc uptake in the plant. Also found within this family are C. elegans proteins of unknown function which are annotated as being similar to human growth arrest inducible gene product, although this protein in not found within this family.","GO:0006351|transcription, DNA-templated;GO:0006355|regulation of transcription, DNA-templated;GO:0006487|protein N-linked glycosylation;GO:0006525|arginine metabolic process;GO:0006824|cobalt ion transport;GO:0006829|zinc ion transport;GO:0006876|cellular cadmium ion homeostasis;GO:0006882|cellular zinc ion homeostasis;GO:0015698|inorganic anion transport;GO:0015701|bicarbonate transport;GO:0030026|cellular manganese ion homeostasis;GO:0030198|extracellular matrix organization;GO:0042391|regulation of membrane potential;GO:0061757|leukocyte adhesion to arterial endothelial cell;GO:0070574|cadmium ion transmembrane transport;GO:0071421|manganese ion transmembrane transport;GO:0071577|zinc ion transmembrane transport;GO:0071578|zinc ion import across plasma membrane;GO:0097080|plasma membrane selenite transport;GO:0098711|iron ion import across plasma membrane;GO:1990079|cartilage homeostasis;GO:1990540|mitochondrial manganese ion transmembrane transport;","GO:0005765|lysosomal membrane;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0031090|organelle membrane;","GO:0005381|iron ion transmembrane transporter activity;GO:0005384|manganese ion transmembrane transporter activity;GO:0005385|zinc ion transmembrane transporter activity;GO:0015086|cadmium ion transmembrane transporter activity;GO:0015087|cobalt ion transmembrane transporter activity;GO:0015106|bicarbonate transmembrane transporter activity;GO:0015296|anion:cation symporter activity;GO:0097079|selenite:proton symporter activity;","K14714","SLC39A8, ZIP8; solute carrier family 39 (zinc transporter), member 8"]
["ENSRNOG00000037853",425,35.75748917,149,9.58523529,3.730475893,1.899359685,{"v":8.8e-50,"d":"8.80E-50"},{"v":6.1e-49,"d":"6.10E-49"},"up","yes","Rarres1","protein_coding","chr2:151749715-151783978:-","gi|62339361|ref|NP_001014790.1|",1366,0,"retinoic acid receptor responder protein 1 precursor [Rattus norvegicus]","gi|114205614|gb|BC105631.1|",1329,0,"Rattus norvegicus retinoic acid receptor responder (tazarotene induced) 1, mRNA (cDNA clone MGC:124894 IMAGE:7386690), complete cds","P49788",405,{"v":4e-138,"d":"4.00E-138"},"Retinoic acid receptor responder protein 1",".",".",".",".","pfam06907","Latexin","Latexin. This family consists of several animal specific latexin proteins. Latexin is a carboxypeptidase A inhibitor and is expressed in a cell type-specific manner in both central and peripheral nervous systems in the rat.","GO:0008285|negative regulation of cell proliferation;GO:0010951|negative regulation of endopeptidase activity;","GO:0005615|extracellular space;","GO:0008191|metalloendopeptidase inhibitor activity;","K23595","RARRES1; retinoic acid receptor responder protein 1"]
["ENSRNOG00000068332",438,36.85124767,159,10.22853967,3.602786796,1.849113279,1.72E-49,1.19E-48,"up","yes","ENSRNOG00000068332","lncRNA","chr17:21500979-21504665:+",".",".",".",".","gi|672081473|ref|XM_006253805.2|",3687,0,"PREDICTED: Rattus norvegicus glucose-fructose oxidoreductase domain containing 1 (Gfod1), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam07223","DUF1421","Protein of unknown function (DUF1421). This family represents a conserved region approximately 350 residues long within a number of plant proteins of unknown function.",".",".",".",".","."]
["ENSRNOG00000038955",260,21.87516985,47,3.023530595,7.234975524,2.854988136,{"v":2.01e-49,"d":"2.01E-49"},{"v":1.39e-48,"d":"1.39E-48"},"up","yes","MGC105567","protein_coding","chr18:53870795-53892024:+","gi|66730425|ref|NP_001019455.1|",2108,0,"uncharacterized protein LOC498873 [Rattus norvegicus]","gi|66730424|ref|NM_001024284.1|",2129,0,"Rattus norvegicus similar to cDNA sequence BC023105 (MGC105567), mRNA","Q9QZ85",429,{"v":8E-136,"d":"8.00E-136"},"Interferon-inducible GTPase 1",".",".",".",".","pfam05049","IIGP","Interferon-inducible GTPase (IIGP). Interferon-inducible GTPase (IIGP) is thought to play a role in in intracellular defence. IIGP is predominantly associated with the Golgi apparatus and also localizes to the endoplasmic reticulum and exerts a distinct role in IFN-induced intracellular membrane trafficking or processing.","GO:0006952|defense response;GO:0035458|cellular response to interferon-beta;","GO:0005789|endoplasmic reticulum membrane;","GO:0003924|GTPase activity;GO:0005525|GTP binding;",".","."]
["ENSRNOG00000015591",1092,91.87571336,709,45.61028067,2.01436413,1.010324498,{"v":2.84e-49,"d":"2.84E-49"},{"v":1.95e-48,"d":"1.95E-48"},"up","yes","Cndp2","protein_coding","chr18:78039932-78056922:-","gi|58219062|ref|NP_001010920.1|",2400,0,"cytosolic non-specific dipeptidase [Rattus norvegicus]","gi|672083294|ref|XM_006254999.2|",2103,0,"PREDICTED: Rattus norvegicus CNDP dipeptidase 2 (metallopeptidase M20 family) (Cndp2), transcript variant X2, mRNA","Q6Q0N1",929,0,"Cytosolic non-specific dipeptidase","SPBC1198.08",474,{"v":3e-159,"d":"3.00E-159"},"COG0624","pfam01546","Peptidase_M20","Peptidase family M20/M25/M40. This family includes a range of zinc metallopeptidases belonging to several families in the peptidase classification. Family M20 are Glutamate carboxypeptidases. Peptidase family M25 contains X-His dipeptidases.","GO:0006508|proteolysis;","GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0004180|carboxypeptidase activity;GO:0008233|peptidase activity;GO:0016805|dipeptidase activity;GO:0046872|metal ion binding;GO:0070573|metallodipeptidase activity;GO:0103046|alanylglutamate dipeptidase activity;","K08660","CNDP2; cytosolic nonspecific dipeptidase [EC:3.4.13.18]"]
["ENSRNOG00000000137",251,21.11795243,43,2.766208842,7.634258162,2.932487974,{"v":5.11e-49,"d":"5.11E-49"},3.47E-48,"up","yes","Ly86","protein_coding","chr17:27415830-27487260:-","gi|157821741|ref|NP_001099598.1|",867,{"v":6e-114,"d":"6.00E-114"},"lymphocyte antigen 86 [Rattus norvegicus]","gi|672081470|ref|XM_006253800.2|",936,0,"PREDICTED: Rattus norvegicus lymphocyte antigen 86 (Ly86), transcript variant X1, mRNA","O88188",265,{"v":5e-87,"d":"5.00E-87"},"Lymphocyte antigen 86",".",".",".",".","pfam02221","E1_DerP2_DerF2","ML domain. ML domain - MD-2-related lipid recognition domain. This family consists of proteins from plants, animals and fungi, including dust mite allergen Der P 2. It has been implicate in lipid recognition, particularly in the recognition of pathogen related products. A mutation in Npc2 causes a rare form of Niemann-Pick type C2 disease. This domain has a similar topology to immunoglobulin domains.","GO:0031666|positive regulation of lipopolysaccharide-mediated signaling pathway;GO:0045087|innate immune response;",".",".",".","."]
["ENSRNOG00000001976",195,16.40637739,1,0.064330438,255.0328872,7.994539488,{"v":5.7e-49,"d":"5.70E-49"},{"v":3.87e-48,"d":"3.87E-48"},"up","yes","Tmprss2","protein_coding","chr11:36934306-36973715:-","gi|149060257|gb|EDM10971.1|",1941,0,"transmembrane protease, serine 2, isoform CRA_b [Rattus norvegicus]","gi|829708433|ref|NM_130424.3|",1831,0,"Rattus norvegicus transmembrane protease, serine 2 (Tmprss2), mRNA","Q9JIQ8",680,0,"Transmembrane protease serine 2","mlr3307",70.5,{"v":7e-12,"d":"7.00E-12"},"COG5640","pfam15494","SRCR_2","Scavenger receptor cysteine-rich domain. SRCR_2 is a scavenger receptor cysteine-rich domain family found largely on vertebrate sequences up-stream of the trypsin-like transmembrane serine protease, Spinesin.","GO:0006508|proteolysis;GO:0006897|endocytosis;GO:0016540|protein autoprocessing;GO:0046598|positive regulation of viral entry into host cell;","GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0004252|serine-type endopeptidase activity;GO:0005044|scavenger receptor activity;","K09633","TMPRSS2; transmembrane protease serine 2 [EC:3.4.21.-]"]
["ENSRNOG00000004317",448,37.69260035,168,10.80751362,3.487629227,1.802246674,{"v":6.75e-49,"d":"6.75E-49"},{"v":4.58e-48,"d":"4.58E-48"},"up","yes","Vipr2","protein_coding","chr6:137001511-137070597:+","gi|465417|sp|P35000.1|VIPR2_RAT",2314,0,"RecName: Full=Vasoactive intestinal polypeptide receptor 2; Short=VIP-R-2; AltName: Full=Pituitary adenylate cyclase-activating polypeptide type III receptor; Short=PACAP type III receptor; Short=PACAP-R-3; Short=PACAP-R3; Flags: Precursor","gi|8394531|ref|NM_017238.1|",3337,0,"Rattus norvegicus vasoactive intestinal peptide receptor 2 (Vipr2), mRNA","P35000",895,0,"Vasoactive intestinal polypeptide receptor 2",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0007166|cell surface receptor signaling pathway;GO:0007188|adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007190|activation of adenylate cyclase activity;GO:0048662|negative regulation of smooth muscle cell proliferation;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004999|vasoactive intestinal polypeptide receptor activity;GO:0008528|G protein-coupled peptide receptor activity;GO:0017046|peptide hormone binding;","K04590","VIPR2; vasoactive intestinal peptide receptor 2"]
["ENSRNOG00000063127",205,17.24773007,21,1.350939202,12.76721413,3.674371851,1.28E-48,{"v":8.65e-48,"d":"8.65E-48"},"up","yes","Ccr2","protein_coding","chr8:123734430-123742100:+","gi|11177914|ref|NP_068638.1|",1741,0,"C-C chemokine receptor type 2 [Rattus norvegicus]","gi|755532612|ref|XM_011243063.1|",2290,0,"PREDICTED: Mus musculus chemokine (C-C motif) receptor 2 (Ccr2), transcript variant X2, mRNA","O55193",675,0,"C-C chemokine receptor type 2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.",".",".",".",".","."]
["ENSRNOG00000006418",311,26.16606855,78,5.017774178,5.214676392,2.382577726,1.57E-48,1.06E-47,"up","yes","Samhd1","protein_coding","chr3:145761558-145794386:-","gi|403225011|ref|NP_001178672.1|",2980,0,"deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [Rattus norvegicus]","gi|403225010|ref|NM_001191743.1|",2036,0,"Rattus norvegicus SAM domain and HD domain, 1 (Samhd1), mRNA","Q60710",1044,0,"Deoxynucleoside triphosphate triphosphohydrolase SAMHD1","TM1547",132,{"v":1e-31,"d":"1.00E-31"},"COG1078","pfam01966","HD","HD domain. HD domains are metal dependent phosphohydrolases.","GO:0000724|double-strand break repair via homologous recombination;GO:0006203|dGTP catabolic process;GO:0006974|cellular response to DNA damage stimulus;GO:0009264|deoxyribonucleotide catabolic process;GO:0016446|somatic hypermutation of immunoglobulin genes;GO:0045088|regulation of innate immune response;GO:0046061|dATP catabolic process;GO:0051289|protein homotetramerization;GO:0051607|defense response to virus;GO:0060339|negative regulation of type I interferon-mediated signaling pathway;GO:0090501|RNA phosphodiester bond hydrolysis;GO:0110025|DNA strand resection involved in replication fork processing;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0035861|site of double-strand break;GO:0097197|tetraspanin-enriched microdomain;","GO:0003676|nucleic acid binding;GO:0003697|single-stranded DNA binding;GO:0003723|RNA binding;GO:0004540|ribonuclease activity;GO:0005525|GTP binding;GO:0008270|zinc ion binding;GO:0008832|dGTPase activity;GO:0016793|triphosphoric monoester hydrolase activity;GO:0032567|dGTP binding;GO:0042802|identical protein binding;","K22544","SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]"]
["ENSRNOG00000007062",625,52.5845429,305,19.62078365,2.680042951,1.422256122,{"v":1.77e-48,"d":"1.77E-48"},1.19E-47,"up","yes","Rin3","protein_coding","chr6:121431339-121540957:+","gi|564357029|ref|XP_006240535.1|",4037,0,"PREDICTED: ras and Rab interactor 3 isoform X2 [Rattus norvegicus]","gi|672056635|ref|XM_008764804.1|",4567,0,"PREDICTED: Rattus norvegicus Ras and Rab interactor 3 (Rin3), transcript variant X3, mRNA","P59729",1391,0,"Ras and Rab interactor 3",".",".",".",".","pfam02204","VPS9","Vacuolar sorting protein 9 (VPS9) domain. This domain acts as a GDP-GTP exchange factor (GEF). It activates Rab GTPases by stimulating the release of GDP and allowing GTP to bind.","GO:0002091|negative regulation of receptor internalization;GO:0007165|signal transduction;GO:0016192|vesicle-mediated transport;GO:0050790|regulation of catalytic activity;GO:0060755|negative regulation of mast cell chemotaxis;GO:0097494|regulation of vesicle size;","GO:0005737|cytoplasm;GO:0005769|early endosome;GO:0030139|endocytic vesicle;GO:0030424|axon;GO:0030425|dendrite;GO:0031410|cytoplasmic vesicle;GO:0031982|vesicle;GO:0043025|neuronal cell body;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0031267|small GTPase binding;","K23687","RIN2_3; Ras and Rab interactor 2/3"]
["ENSRNOG00000014448",491,41.31041691,202,12.99474851,3.179008571,1.668576906,{"v":3.84e-48,"d":"3.84E-48"},{"v":2.56e-47,"d":"2.56E-47"},"up","yes","Arntl","protein_coding","chr1:167331633-167430231:+","gi|817283650|ref|XP_012312038.1|",3111,0,"PREDICTED: aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X3 [Aotus nancymaae]","gi|672037826|ref|XM_008759716.1|",2245,0,"PREDICTED: Rattus norvegicus aryl hydrocarbon receptor nuclear translocator-like (Arntl), transcript variant X2, mRNA","Q9EPW1",1177,0,"Aryl hydrocarbon receptor nuclear translocator-like protein 1",".",".",".",".","pfam14598","PAS_11","PAS domain. This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).","GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006606|protein import into nucleus;GO:0007283|spermatogenesis;GO:0007623|circadian rhythm;GO:0032007|negative regulation of TOR signaling;GO:0032922|circadian regulation of gene expression;GO:0042176|regulation of protein catabolic process;GO:0042634|regulation of hair cycle;GO:0042753|positive regulation of circadian rhythm;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045599|negative regulation of fat cell differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050767|regulation of neurogenesis;GO:0050796|regulation of insulin secretion;GO:0051726|regulation of cell cycle;GO:0051775|response to redox state;GO:0060137|maternal process involved in parturition;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:0090403|oxidative stress-induced premature senescence;GO:0120163|negative regulation of cold-induced thermogenesis;GO:1901985|positive regulation of protein acetylation;GO:2000074|regulation of type B pancreatic cell development;GO:2000323|negative regulation of glucocorticoid receptor signaling pathway;GO:2000772|regulation of cellular senescence;GO:2001016|positive regulation of skeletal muscle cell differentiation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005737|cytoplasm;GO:0016604|nuclear body;GO:0016605|PML body;GO:0033391|chromatoid body;GO:0034751|aryl hydrocarbon receptor complex;GO:0043231|intracellular membrane-bounded organelle;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0017162|aryl hydrocarbon receptor binding;GO:0043425|bHLH transcription factor binding;GO:0043565|sequence-specific DNA binding;GO:0046982|protein heterodimerization activity;GO:0046983|protein dimerization activity;GO:0051879|Hsp90 protein binding;GO:0070888|E-box binding;GO:1990837|sequence-specific double-stranded DNA binding;","K02296","ARNTL, BMAL1, CYC; aryl hydrocarbon receptor nuclear translocator-like protein 1"]
["ENSRNOG00000002843",218,18.34148856,0,0.032165219,570.2273786,9.1553935,{"v":4.73e-48,"d":"4.73E-48"},{"v":3.14e-47,"d":"3.14E-47"},"up","yes","Cxcl6","protein_coding","chr14:17310426-17313093:-","gi|672075826|ref|XP_008768277.1|",517,{"v":2e-59,"d":"2.00E-59"},"PREDICTED: C-X-C motif chemokine 5 isoform X2 [Rattus norvegicus]","gi|672075825|ref|XM_008770055.1|",1378,0,"PREDICTED: Rattus norvegicus chemokine (C-X-C motif) ligand 6 (Cxcl6), transcript variant X3, mRNA","P97885",202,{"v":2e-60,"d":"2.00E-60"},"C-X-C motif chemokine 5",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0001776|leukocyte homeostasis;GO:0006952|defense response;GO:0006954|inflammatory response;GO:0007165|signal transduction;GO:0010332|response to gamma radiation;GO:0010976|positive regulation of neuron projection development;GO:0030593|neutrophil chemotaxis;GO:0030901|midbrain development;GO:0031100|animal organ regeneration;GO:0032496|response to lipopolysaccharide;GO:0032642|regulation of chemokine production;GO:0042119|neutrophil activation;GO:0046427|positive regulation of JAK-STAT cascade;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098|chemokine-mediated signaling pathway;GO:0070951|regulation of neutrophil mediated killing of gram-negative bacterium;GO:0071222|cellular response to lipopolysaccharide;","GO:0005615|extracellular space;","GO:0008009|chemokine activity;GO:0045236|CXCR chemokine receptor binding;","K05506","CXCL5_6, SCYB5_6; C-X-C motif chemokine 5/6"]
["ENSRNOG00000028768",203,17.07945954,21,1.350939202,12.64265595,3.660227669,4.96E-48,{"v":3.29e-47,"d":"3.29E-47"},"up","yes","Gbp4","protein_coding","chr2:231305244-231318879:+","gi|149026108|gb|EDL82351.1|",3190,0,"rCG28728, isoform CRA_a [Rattus norvegicus]","gi|765365471|ref|NM_001305261.1|",2560,0,"Rattus norvegicus guanylate binding protein 4 (Gbp4), mRNA","Q61107",1088,0,"Guanylate-binding protein 4",".",".",".",".","pfam02263","GBP","Guanylate-binding protein, N-terminal domain. Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.","GO:0035458|cellular response to interferon-beta;GO:0042832|defense response to protozoan;GO:0044406|adhesion of symbiont to host;GO:0050830|defense response to Gram-positive bacterium;GO:0071346|cellular response to interferon-gamma;","GO:0005634|nucleus;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0031410|cytoplasmic vesicle;GO:0048471|perinuclear region of cytoplasm;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;","K20899","GBP1_3_4_7; guanylate-binding protein 1/3/4/7"]
["ENSRNOG00000021100",520,43.7503397,225,14.47434859,3.022611997,1.595795797,{"v":7.73e-48,"d":"7.73E-48"},{"v":5.1e-47,"d":"5.10E-47"},"up","yes","Tnfaip8l2","protein_coding","chr2:182709378-182726760:-","gi|62078809|ref|NP_001014061.1|",870,{"v":1e-105,"d":"1.00E-105"},"tumor necrosis factor alpha-induced protein 8-like protein 2 [Rattus norvegicus]","gi|672043420|ref|XM_008761303.1|",2137,0,"PREDICTED: Rattus norvegicus tumor necrosis factor, alpha-induced protein 8-like 2 (Tnfaip8l2), transcript variant X1, mRNA","Q6AYJ8",339,{"v":4E-107,"d":"4.00E-107"},"Tumor necrosis factor alpha-induced protein 8-like protein 2",".",".",".",".","pfam05527","DUF758","Domain of unknown function (DUF758). Family of eukaryotic proteins with unknown function, which are induced by tumor necrosis factor.","GO:0042981|regulation of apoptotic process;GO:0045087|innate immune response;GO:0050728|negative regulation of inflammatory response;GO:0050868|negative regulation of T cell activation;","GO:0005737|cytoplasm;",".",".","."]
["ENSRNOG00000031232",916,77.06790608,560,36.02504538,2.139286856,1.097129946,{"v":2.3e-47,"d":"2.30E-47"},{"v":1.49e-46,"d":"1.49E-46"},"up","yes","Nrp2","protein_coding","chr9:64123132-64237958:+","gi|672065269|ref|XP_008765359.1|",4880,0,"PREDICTED: neuropilin-2 isoform X2 [Rattus norvegicus]","gi|672065268|ref|XM_008767137.1|",3980,0,"PREDICTED: Rattus norvegicus neuropilin 2 (Nrp2), transcript variant X2, mRNA","O35276",1864,0,"Neuropilin-2",".",".",".",".","pfam00629","MAM","MAM domain. An extracellular domain found in many receptors.","GO:0001525|angiogenesis;GO:0001755|neural crest cell migration;GO:0001764|neuron migration;GO:0003148|outflow tract septum morphogenesis;GO:0007411|axon guidance;GO:0007507|heart development;GO:0021612|facial nerve structural organization;GO:0021649|vestibulocochlear nerve structural organization;GO:0021675|nerve development;GO:0021828|gonadotrophin-releasing hormone neuronal migration to the hypothalamus;GO:0036486|ventral trunk neural crest cell migration;GO:0038084|vascular endothelial growth factor signaling pathway;GO:0048846|axon extension involved in axon guidance;GO:0050919|negative chemotaxis;GO:0061549|sympathetic ganglion development;GO:0061551|trigeminal ganglion development;GO:0097374|sensory neuron axon guidance;GO:0097490|sympathetic neuron projection extension;GO:0097491|sympathetic neuron projection guidance;GO:0099175|regulation of postsynapse organization;GO:1901166|neural crest cell migration involved in autonomic nervous system development;GO:1902285|semaphorin-plexin signaling pathway involved in neuron projection guidance;GO:1903375|facioacoustic ganglion development;GO:1904835|dorsal root ganglion morphogenesis;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0030424|axon;GO:0098978|glutamatergic synapse;GO:0099055|integral component of postsynaptic membrane;","GO:0005021|vascular endothelial growth factor-activated receptor activity;GO:0008201|heparin binding;GO:0017154|semaphorin receptor activity;GO:0042802|identical protein binding;GO:0046872|metal ion binding;","K06819","NRP2; neuropilin 2"]
["ENSRNOG00000003189",449,37.77673562,174,11.19349624,3.374882592,1.754837314,{"v":2.72e-47,"d":"2.72E-47"},{"v":1.76e-46,"d":"1.76E-46"},"up","yes","Cited1","protein_coding","chrX:67350373-67355162:-","gi|564399592|ref|XP_006257159.1|",848,{"v":2e-110,"d":"2.00E-110"},"PREDICTED: cbp/p300-interacting transactivator 1 isoform X2 [Rattus norvegicus]","gi|67972659|ref|NM_172055.2|",834,0,"Rattus norvegicus Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 (Cited1), mRNA","P97769",263,{"v":1e-85,"d":"1.00E-85"},"Cbp/p300-interacting transactivator 1",".",".",".",".","pfam04487","CITED","CITED. CITED, CBP/p300-interacting transactivator with ED-rich tail, are characterized by a conserved 32-amino acid sequence at the C-terminus. CITED proteins do not bind DNA directly and are thought to function as transcriptional co-activators.","GO:0000578|embryonic axis specification;GO:0001570|vasculogenesis;GO:0001658|branching involved in ureteric bud morphogenesis;GO:0001890|placenta development;GO:0003340|negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0006913|nucleocytoplasmic transport;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0007420|brain development;GO:0010628|positive regulation of gene expression;GO:0030318|melanocyte differentiation;GO:0032496|response to lipopolysaccharide;GO:0032868|response to insulin;GO:0034097|response to cytokine;GO:0034341|response to interferon-gamma;GO:0042438|melanin biosynthetic process;GO:0042981|regulation of apoptotic process;GO:0043473|pigmentation;GO:0043524|negative regulation of neuron apoptotic process;GO:0043627|response to estrogen;GO:0045668|negative regulation of osteoblast differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051591|response to cAMP;GO:0060395|SMAD protein signal transduction;GO:0060711|labyrinthine layer development;GO:0060712|spongiotrophoblast layer development;GO:0070555|response to interleukin-1;GO:0070669|response to interleukin-2;GO:0070670|response to interleukin-4;GO:0070741|response to interleukin-6;GO:0071104|response to interleukin-9;GO:0071105|response to interleukin-11;GO:0071107|response to parathyroid hormone;GO:0071559|response to transforming growth factor beta;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0003682|chromatin binding;GO:0003713|transcription coactivator activity;GO:0008022|protein C-terminus binding;GO:0042803|protein homodimerization activity;GO:0050693|LBD domain binding;GO:0070410|co-SMAD binding;","K22527","CITED1; Cbp/p300-interacting transactivator 1"]
["ENSRNOG00000016413",384,32.30794316,130,8.362956964,3.863220067,1.949803862,{"v":1.08e-46,"d":"1.08E-46"},6.94E-46,"up","yes","Pstpip1","protein_coding","chr8:56499590-56538580:+","gi|166157470|ref|NP_001100294.2|",2073,0,"proline-serine-threonine phosphatase-interacting protein 1 [Rattus norvegicus]","gi|166157469|ref|NM_001106824.2|",1539,0,"Rattus norvegicus proline-serine-threonine phosphatase-interacting protein 1 (Pstpip1), mRNA","P97814",768,0,"Proline-serine-threonine phosphatase-interacting protein 1",".",".",".",".","pfam00611","FCH","Fes/CIP4, and EFC/F-BAR homology domain. Alignment extended from. Highly alpha-helical. The cytosolic endocytic adaptor proteins in fungi carry this domain at the N-terminus; several of these have been referred to as muniscin proteins. These N-terminal BAR, N-BAR, and EFC/F-BAR domains are found in proteins that regulate membrane trafficking events by inducing membrane tubulation. The domain dimerises into a curved structure that binds to liposomes and either senses or induces the curvature of the membrane bilayer to cause biophysical changes to the shape of the bilayer; it also thereby recruits other trafficking factors, such as the GTPase dynamin. Most EFC/F-BAR domain-family members localize to actin-rich structures.","GO:0008150|biological_process;GO:0030041|actin filament polymerization;","GO:0001725|stress fiber;GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005826|actomyosin contractile ring;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0032154|cleavage furrow;","GO:0003674|molecular_function;GO:0003779|actin binding;GO:0019903|protein phosphatase binding;GO:0042802|identical protein binding;GO:0051015|actin filament binding;","K12804","PSTPIP1; proline-serine-threonine phosphatase interacting protein 1"]
["ENSRNOG00000017277",294,24.73576898,73,4.696121987,5.267275647,2.397056961,{"v":2.74e-46,"d":"2.74E-46"},1.75E-45,"up","yes","Igsf6","protein_coding","chr1:175610167-175620722:-","gi|149068040|gb|EDM17592.1|",1123,{"v":2e-145,"d":"2.00E-145"},"immunoglobulin superfamily, member 6 [Rattus norvegicus]","gi|451958097|ref|NM_133542.2|",2223,0,"Rattus norvegicus immunoglobulin superfamily, member 6 (Igsf6), mRNA","Q9Z0K5",434,{"v":1e-145,"d":"1.00E-145"},"Immunoglobulin superfamily member 6",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000049829",164,13.79818406,6,0.385982629,35.74819958,5.159798679,{"v":6.15e-46,"d":"6.15E-46"},{"v":3.92e-45,"d":"3.92E-45"},"up","yes","AABR07060872.1","protein_coding","chr4:102404346-102688488:+","gi|92401|pir||S06084",887,{"v":1e-116,"d":"1.00E-116"},"Ig kappa chain precursor - rat","gi|298890810|emb|FQ230756.1|",742,0,"Rattus norvegicus TL0AEA8YC24 mRNA sequence","P0DOX7",248,{"v":5E-80,"d":"5.00E-80"},"Immunoglobulin kappa light chain",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.",".",".",".",".","."]
["ENSRNOG00000008180",1008,84.8083508,654,42.07210657,2.0157857,1.011342273,1.08E-45,{"v":6.87e-45,"d":"6.87E-45"},"up","yes","Lyn","protein_coding","chr5:16639466-16756868:+","gi|674050187|ref|XP_008831300.1|",2796,0,"PREDICTED: tyrosine-protein kinase Lyn isoform X1 [Nannospalax galili]","gi|162287329|ref|NM_030857.2|",3430,0,"Rattus norvegicus LYN proto-oncogene, Src family tyrosine kinase (Lyn), transcript variant 1, mRNA","Q07014",1068,0,"Tyrosine-protein kinase Lyn",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001782|B cell homeostasis;GO:0001817|regulation of cytokine production;GO:0001933|negative regulation of protein phosphorylation;GO:0001934|positive regulation of protein phosphorylation;GO:0002250|adaptive immune response;GO:0002431|Fc receptor mediated stimulatory signaling pathway;GO:0002513|tolerance induction to self antigen;GO:0002553|histamine secretion by mast cell;GO:0002576|platelet degranulation;GO:0002762|negative regulation of myeloid leukocyte differentiation;GO:0002768|immune response-regulating cell surface receptor signaling pathway;GO:0002774|Fc receptor mediated inhibitory signaling pathway;GO:0002902|regulation of B cell apoptotic process;GO:0006468|protein phosphorylation;GO:0006974|cellular response to DNA damage stimulus;GO:0006991|response to sterol depletion;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0009410|response to xenobiotic stimulus;GO:0009636|response to toxic substance;GO:0009725|response to hormone;GO:0009743|response to carbohydrate;GO:0010976|positive regulation of neuron projection development;GO:0014003|oligodendrocyte development;GO:0014070|response to organic cyclic compound;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0030097|hemopoiesis;GO:0030154|cell differentiation;GO:0030218|erythrocyte differentiation;GO:0030335|positive regulation of cell migration;GO:0030889|negative regulation of B cell proliferation;GO:0031175|neuron projection development;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0031668|cellular response to extracellular stimulus;GO:0032868|response to insulin;GO:0033003|regulation of mast cell activation;GO:0033628|regulation of cell adhesion mediated by integrin;GO:0034136|negative regulation of toll-like receptor 2 signaling pathway;GO:0034142|toll-like receptor 4 signaling pathway;GO:0034144|negative regulation of toll-like receptor 4 signaling pathway;GO:0034605|cellular response to heat;GO:0035556|intracellular signal transduction;GO:0042327|positive regulation of phosphorylation;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0043200|response to amino acid;GO:0043304|regulation of mast cell degranulation;GO:0043407|negative regulation of MAP kinase activity;GO:0043434|response to peptide hormone;GO:0043552|positive regulation of phosphatidylinositol 3-kinase activity;GO:0045087|innate immune response;GO:0045646|regulation of erythrocyte differentiation;GO:0046777|protein autophosphorylation;GO:0048678|response to axon injury;GO:0050727|regulation of inflammatory response;GO:0050853|B cell receptor signaling pathway;GO:0050855|regulation of B cell receptor signaling pathway;GO:0051272|positive regulation of cellular component movement;GO:0051279|regulation of release of sequestered calcium ion into cytosol;GO:0060252|positive regulation of glial cell proliferation;GO:0060369|positive regulation of Fc receptor mediated stimulatory signaling pathway;GO:0070304|positive regulation of stress-activated protein kinase signaling cascade;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0070447|positive regulation of oligodendrocyte progenitor proliferation;GO:0070667|negative regulation of mast cell proliferation;GO:0070668|positive regulation of mast cell proliferation;GO:0071300|cellular response to retinoic acid;GO:0090025|regulation of monocyte chemotaxis;GO:0090330|regulation of platelet aggregation;GO:0097028|dendritic cell differentiation;GO:1902532|negative regulation of intracellular signal transduction;GO:1902961|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process;GO:2000670|positive regulation of dendritic cell apoptotic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005758|mitochondrial intermembrane space;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005912|adherens junction;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0030061|mitochondrial crista;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0031966|mitochondrial membrane;GO:0032991|protein-containing complex;GO:0034666|integrin alpha2-beta1 complex;GO:0043231|intracellular membrane-bounded organelle;GO:0045121|membrane raft;GO:0048471|perinuclear region of cytoplasm;GO:0098978|glutamatergic synapse;GO:0099091|postsynaptic specialization, intracellular component;","GO:0004672|protein kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0005102|signaling receptor binding;GO:0005161|platelet-derived growth factor receptor binding;GO:0005178|integrin binding;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0016301|kinase activity;GO:0017124|SH3 domain binding;GO:0019899|enzyme binding;GO:0031625|ubiquitin protein ligase binding;GO:0043015|gamma-tubulin binding;GO:0043208|glycosphingolipid binding;GO:0044325|ion channel binding;GO:0044877|protein-containing complex binding;GO:0046875|ephrin receptor binding;GO:0051219|phosphoprotein binding;GO:0097110|scaffold protein binding;GO:0140031|phosphorylation-dependent protein binding;","K05854","LYN; tyrosine-protein kinase Lyn [EC:2.7.10.2]"]
["ENSRNOG00000008759",199,16.74291846,24,1.543930516,10.84434713,3.438871295,{"v":5.42e-45,"d":"5.42E-45"},3.41E-44,"up","yes","Csf3r","protein_coding","chr5:138301506-138317881:+","gi|672053656|ref|XP_008762225.1|",4381,0,"PREDICTED: granulocyte colony-stimulating factor receptor isoform X2 [Rattus norvegicus]","gi|672053663|ref|XM_008764007.1|",2113,0,"PREDICTED: Rattus norvegicus colony stimulating factor 3 receptor (granulocyte) (Csf3r), transcript variant X5, mRNA","P40223",1395,0,"Granulocyte colony-stimulating factor receptor",".",".",".",".","pfam06328","Lep_receptor_Ig","Ig-like C2-type domain. This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.","GO:0019221|cytokine-mediated signaling pathway;GO:0030593|neutrophil chemotaxis;GO:0045637|regulation of myeloid cell differentiation;GO:0097186|amelogenesis;","GO:0005575|cellular_component;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0043235|receptor complex;","GO:0003674|molecular_function;GO:0004896|cytokine receptor activity;GO:0019955|cytokine binding;GO:0051916|granulocyte colony-stimulating factor binding;","K05061","CSF3R, CD114; granulocyte colony-stimulating factor receptor"]
["ENSRNOG00000024931",320,26.92328597,93,5.982730751,4.500166744,2.169978459,{"v":9.9e-45,"d":"9.90E-45"},{"v":6.18e-44,"d":"6.18E-44"},"up","yes","Ccdc88b","protein_coding","chr1:204036918-204052970:-","gi|109463441|ref|XP_001072042.1|",5985,0,"PREDICTED: coiled-coil domain-containing protein 88B [Rattus norvegicus]","gi|672014616|ref|XM_001072042.4|",4908,0,"PREDICTED: Rattus norvegicus coiled-coil domain containing 88B (Ccdc88b), mRNA","Q4QRL3",2004,0,"Coiled-coil domain-containing protein 88B",".",".",".",".","pfam05622","HOOK","HOOK protein. This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organisms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas the central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head.","GO:0001819|positive regulation of cytokine production;GO:0030705|cytoskeleton-dependent intracellular transport;GO:0031122|cytoplasmic microtubule organization;GO:0042102|positive regulation of T cell proliferation;GO:0042832|defense response to protozoan;GO:0050870|positive regulation of T cell activation;","GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0016020|membrane;","GO:0008017|microtubule binding;GO:0051959|dynein light intermediate chain binding;",".","."]
["ENSRNOG00000006735",996,83.79872757,649,41.75045438,2.007133307,1.005136439,{"v":9.91e-45,"d":"9.91E-45"},{"v":6.18e-44,"d":"6.18E-44"},"up","yes","Cdkn2b","protein_coding","chr5:104010680-104019050:-","gi|18677739|ref|NP_570825.1|",665,{"v":5E-79,"d":"5.00E-79"},"cyclin-dependent kinase 4 inhibitor B [Rattus norvegicus]","gi|683523985|ref|NM_130812.3|",2304,0,"Rattus norvegicus cyclin-dependent kinase inhibitor 2B (Cdkn2b), mRNA","P55272",260,{"v":2e-80,"d":"2.00E-80"},"Cyclin-dependent kinase 4 inhibitor B",".",".",".",".","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0000079|regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0000086|G2/M transition of mitotic cell cycle;GO:0001889|liver development;GO:0007568|aging;GO:0008285|negative regulation of cell proliferation;GO:0014070|response to organic cyclic compound;GO:0030219|megakaryocyte differentiation;GO:0030511|positive regulation of transforming growth factor beta receptor signaling pathway;GO:0030858|positive regulation of epithelial cell differentiation;GO:0031668|cellular response to extracellular stimulus;GO:0031670|cellular response to nutrient;GO:0034097|response to cytokine;GO:0042326|negative regulation of phosphorylation;GO:0045736|negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0048536|spleen development;GO:0050680|negative regulation of epithelial cell proliferation;GO:0051726|regulation of cell cycle;GO:0060253|negative regulation of glial cell proliferation;GO:0070316|regulation of G0 to G1 transition;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0090398|cellular senescence;GO:1902807|negative regulation of cell cycle G1/S phase transition;GO:2000134|negative regulation of G1/S transition of mitotic cell cycle;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0003674|molecular_function;GO:0004861|cyclin-dependent protein serine/threonine kinase inhibitor activity;GO:0019901|protein kinase binding;","K04685","CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B"]
["ENSRNOG00000013408",269,22.63238727,63,4.052817606,5.584358703,2.481391614,{"v":3.67e-44,"d":"3.67E-44"},{"v":2.26e-43,"d":"2.26E-43"},"up","yes","Npas2","protein_coding","chr9:41463830-41642320:+","gi|210032658|ref|NP_001101684.2|",3666,0,"neuronal PAS domain-containing protein 2 [Rattus norvegicus]","gi|210032657|ref|NM_001108214.2|",4273,0,"Rattus norvegicus neuronal PAS domain protein 2 (Npas2), mRNA","P97460",1357,0,"Neuronal PAS domain-containing protein 2",".",".",".",".","pfam14598","PAS_11","PAS domain. This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).","GO:0006357|regulation of transcription by RNA polymerase II;GO:0007623|circadian rhythm;GO:0009410|response to xenobiotic stimulus;GO:0032922|circadian regulation of gene expression;GO:0042745|circadian sleep/wake cycle;GO:0042752|regulation of circadian rhythm;GO:0045475|locomotor rhythm;GO:0045739|positive regulation of DNA repair;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051775|response to redox state;GO:0060548|negative regulation of cell death;GO:2000987|positive regulation of behavioral fear response;GO:2001020|regulation of response to DNA damage stimulus;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005829|cytosol;GO:1990513|CLOCK-BMAL transcription complex;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0046983|protein dimerization activity;GO:0051879|Hsp90 protein binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09026","NPAS2; neuronal PAS domain-containing protein 2"]
["ENSRNOG00000065195",236,19.8559234,45,2.894869718,6.859004146,2.777999128,{"v":7.88e-44,"d":"7.88E-44"},{"v":4.82e-43,"d":"4.82E-43"},"up","yes","ENSRNOG00000065195","protein_coding","chr6:131831454-131854463:-","gi|672057367|ref|XP_008763214.1|",26725,0,"PREDICTED: protein AHNAK2 isoform X2, partial [Rattus norvegicus]","gi|672057366|ref|XM_008764992.1|",9105,0,"PREDICTED: Rattus norvegicus AHNAK nucleoprotein 2 (Ahnak2), transcript variant X2, partial mRNA","Q8IVF2",3713,0,"Protein AHNAK2",".",".",".",".","pfam05109","Herpes_BLLF1","Herpes virus major outer envelope glycoprotein (BLLF1). This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralizing antibodies in vivo.",".",".",".",".","."]
["ENSRNOG00000020953",226,19.01457071,40,2.573217527,7.389414424,2.885460042,1.23E-43,{"v":7.52e-43,"d":"7.52E-43"},"up","yes","Ms4a7","protein_coding","chr1:207968761-207983260:-","gi|157823009|ref|NP_001099808.1|",1150,{"v":6E-153,"d":"6.00E-153"},"membrane-spanning 4-domains subfamily A member 7 [Rattus norvegicus]","gi|448824828|ref|NM_001276398.1|",939,0,"Mus musculus membrane-spanning 4-domains, subfamily A, member 7 (Ms4a7), transcript variant 3, mRNA","Q9GZW8",196,{"v":7e-57,"d":"7.00E-57"},"Membrane-spanning 4-domains subfamily A member 7",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.",".","GO:0005802|trans-Golgi network;GO:0016021|integral component of membrane;",".","K22191","MS4A5_6_7; membrane-spanning 4-domains subfamily A member 5/6/7"]
["ENSRNOG00000059140",317,26.67088016,94,6.047061189,4.410552387,2.140959353,{"v":1.29e-43,"d":"1.29E-43"},{"v":7.86e-43,"d":"7.86E-43"},"up","yes","Myo1g","protein_coding","chr14:81386701-81401843:-","gi|564384294|ref|XP_006251280.1|",5241,0,"PREDICTED: unconventional myosin-Ig isoform X1 [Rattus norvegicus]","gi|672076641|ref|XM_006251218.2|",3301,0,"PREDICTED: Rattus norvegicus myosin IG (Myo1g), transcript variant X1, mRNA","Q5SUA5",1971,0,"Unconventional myosin-Ig","YKL129c",498,{"v":2e-154,"d":"2.00E-154"},"COG5022","pfam00063","Myosin_head","Myosin head (motor domain).","GO:0002456|T cell mediated immunity;GO:0006887|exocytosis;GO:0006909|phagocytosis;GO:0031589|cell-substrate adhesion;GO:0038096|Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0071976|cell gliding;GO:0120117|T cell meandering migration;","GO:0001891|phagocytic cup;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0005902|microvillus;GO:0016459|myosin complex;GO:0030027|lamellipodium;GO:0030175|filopodium;GO:0031256|leading edge membrane;","GO:0005516|calmodulin binding;GO:0005524|ATP binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;GO:0043325|phosphatidylinositol-3,4-bisphosphate binding;","K10356","MYO1; myosin I"]
["ENSRNOG00000002776",167,14.05058986,12,0.771965258,18.20106503,4.185950966,{"v":2.97e-43,"d":"2.97E-43"},{"v":1.8e-42,"d":"1.80E-42"},"up","yes","Sell","protein_coding","chr13:76416915-76436456:+","gi|94400781|ref|NP_062050.3|",1896,0,"L-selectin precursor [Rattus norvegicus]","gi|94400780|ref|NM_019177.3|",1187,0,"Rattus norvegicus selectin L (Sell), mRNA","P30836",729,0,"L-selectin",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0016339|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0033198|response to ATP;GO:0034201|response to oleic acid;GO:0042981|regulation of apoptotic process;GO:0050901|leukocyte tethering or rolling;GO:0055093|response to hyperoxia;GO:0070543|response to linoleic acid;GO:0090023|positive regulation of neutrophil chemotaxis;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;","GO:0002020|protease binding;GO:0005509|calcium ion binding;GO:0050839|cell adhesion molecule binding;GO:0051861|glycolipid binding;GO:0070492|oligosaccharide binding;","K06495","SELL, CD62L; selectin, lymphocyte"]
["ENSRNOG00000016456",287,24.1468221,77,4.95344374,4.874754488,2.285329561,{"v":7.88e-43,"d":"7.88E-43"},4.73E-42,"up","yes","Il33","protein_coding","chr1:227721435-227736373:+","gi|62079057|ref|NP_001014188.1|",808,{"v":9e-96,"d":"9.00E-96"},"interleukin-33 [Rattus norvegicus]","gi|62079056|ref|NM_001014166.1|",2051,0,"Rattus norvegicus interleukin 33 (Il33), mRNA","Q66H70",315,{"v":3e-97,"d":"3.00E-97"},"Interleukin-33",".",".",".",".","pfam15095","IL33","Interleukin 33.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001819|positive regulation of cytokine production;GO:0002281|macrophage activation involved in immune response;GO:0002282|microglial cell activation involved in immune response;GO:0002638|negative regulation of immunoglobulin production;GO:0002639|positive regulation of immunoglobulin production;GO:0002686|negative regulation of leukocyte migration;GO:0002826|negative regulation of T-helper 1 type immune response;GO:0002830|positive regulation of type 2 immune response;GO:0010186|positive regulation of cellular defense response;GO:0010628|positive regulation of gene expression;GO:0032436|positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032689|negative regulation of interferon-gamma production;GO:0032722|positive regulation of chemokine production;GO:0032736|positive regulation of interleukin-13 production;GO:0032753|positive regulation of interleukin-4 production;GO:0032754|positive regulation of interleukin-5 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0038172|interleukin-33-mediated signaling pathway;GO:0042060|wound healing;GO:0043032|positive regulation of macrophage activation;GO:0045345|positive regulation of MHC class I biosynthetic process;GO:0045348|positive regulation of MHC class II biosynthetic process;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048714|positive regulation of oligodendrocyte differentiation;GO:0050729|positive regulation of inflammatory response;GO:0051607|defense response to virus;GO:0051770|positive regulation of nitric-oxide synthase biosynthetic process;GO:0051930|regulation of sensory perception of pain;GO:0061518|microglial cell proliferation;GO:0071260|cellular response to mechanical stimulus;GO:0097191|extrinsic apoptotic signaling pathway;GO:0120042|negative regulation of macrophage proliferation;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005694|chromosome;GO:0005737|cytoplasm;GO:0030133|transport vesicle;GO:0043231|intracellular membrane-bounded organelle;","GO:0002112|interleukin-33 receptor binding;GO:0005125|cytokine activity;GO:0005515|protein binding;","K12967","IL33; interleukin 33"]
["ENSRNOG00000007129",163,13.71404879,11,0.70763482,19.3801215,4.27650571,{"v":1E-42,"d":"1.00E-42"},{"v":6.02e-42,"d":"6.02E-42"},"up","yes","Cd8b","protein_coding","chr4:103312578-103328553:+","gi|37590779|gb|AAH59127.1|",860,{"v":5E-110,"d":"5.00E-110"},"CD8b molecule [Rattus norvegicus]","gi|37590778|gb|BC059127.1|",673,0,"Rattus norvegicus CD8b molecule, mRNA (cDNA clone MGC:72771 IMAGE:6888323), complete cds","P05541",332,{"v":7e-110,"d":"7.00E-110"},"T-cell surface glycoprotein CD8 beta chain",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0002250|adaptive immune response;GO:0050776|regulation of immune response;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0015026|coreceptor activity;GO:0042288|MHC class I protein binding;","K06459","CD8B; T-cell surface glycoprotein CD8 beta chain"]
["ENSRNOG00000031930",337,28.35358553,111,7.140678639,3.970713005,1.98939809,{"v":2.99e-42,"d":"2.99E-42"},{"v":1.77e-41,"d":"1.77E-41"},"up","yes","Bin2","protein_coding","chr7:131742002-131786285:-","gi|444515345|gb|ELV10844.1|",2327,0,"Bridging integrator 2 [Tupaia chinensis]","gi|58866017|ref|NM_001012223.1|",1801,0,"Rattus norvegicus bridging integrator 2 (Bin2), mRNA","Q68FR2",597,0,"Bridging integrator 2","VC1649",81.6,{"v":3e-15,"d":"3.00E-15"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006911|phagocytosis, engulfment;GO:0060326|cell chemotaxis;GO:0071800|podosome assembly;GO:0097320|plasma membrane tubulation;","GO:0001891|phagocytic cup;GO:0002102|podosome;GO:0005886|plasma membrane;GO:0005938|cell cortex;GO:0030054|cell junction;GO:0042995|cell projection;","GO:0005543|phospholipid binding;","K20119","BIN2; bridging integrator 2"]
["ENSRNOG00000007495",269,22.63238727,68,4.374469797,5.173744092,2.371208696,{"v":5.5E-42,"d":"5.50E-42"},{"v":3.24e-41,"d":"3.24E-41"},"up","yes","ENSRNOG00000007495","protein_coding","chrX:37234294-37276708:-","gi|16758124|ref|NP_445847.1|",366,{"v":5e-41,"d":"5.00E-41"},"small muscular protein [Rattus norvegicus]","gi|672087512|ref|XM_006256945.2|",654,0,"PREDICTED: Rattus norvegicus small muscle protein, X-linked (Smpx), transcript variant X1, mRNA","Q925F0",145,{"v":2e-42,"d":"2.00E-42"},"Small muscular protein",".",".",".",".","pfam15355","Chisel","Stretch-responsive small skeletal muscle X protein, Chisel. The murine X-linked gene Chisel (Csl/Smpx) is selectively expressed in cardiac and skeletal muscle cells. It localizes to the costameric cytoskeleton of muscle cells through its association with focal adhesion proteins, where it may participate in regulating the dynamics of actin through the Rac1/p38 kinase pathway. Thus it is implicated in the maintenance of muscle integrity and in responses to biomechanical stress.",".","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005927|muscle tendon junction;GO:0031430|M band;GO:0043034|costamere;GO:0043292|contractile fiber;",".","K24209","SMPX; small muscular protein"]
["ENSRNOG00000019490",897,75.46933598,575,36.99000196,2.040263098,1.028755204,{"v":5.73e-42,"d":"5.73E-42"},{"v":3.36e-41,"d":"3.36E-41"},"up","yes","Slc20a2","protein_coding","chr16:69460462-69521711:-","gi|8394288|ref|NP_058919.1|",2946,0,"sodium-dependent phosphate transporter 2 precursor [Rattus norvegicus]","gi|672080503|ref|XM_008771351.1|",3823,0,"PREDICTED: Rattus norvegicus solute carrier family 20 (phosphate transporter), member 2 (Slc20a2), transcript variant X1, mRNA","Q63488",1139,0,"Sodium-dependent phosphate transporter 2","AF1798",147,{"v":5e-37,"d":"5.00E-37"},"COG0306","pfam01384","PHO4","Phosphate transporter family. This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.","GO:0006814|sodium ion transport;GO:0006817|phosphate ion transport;GO:0035435|phosphate ion transmembrane transport;GO:0055085|transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;","GO:0005315|inorganic phosphate transmembrane transporter activity;GO:0015293|symporter activity;","K14640","SLC20A, PIT; solute carrier family 20 (sodium-dependent phosphate transporter)"]
["ENSRNOG00000045992",251,21.11795243,58,3.731165415,5.659881051,2.500771734,{"v":1.13e-41,"d":"1.13E-41"},{"v":6.55e-41,"d":"6.55E-41"},"up","yes","ENSRNOG00000045992","protein_coding","chrX:27091778-27116549:+","gi|149035901|gb|EDL90568.1|",5084,0,"rCG49623 [Rattus norvegicus]","gi|155369699|ref|NM_001101009.1|",3381,0,"Rattus norvegicus toll-like receptor 8 (Tlr8), mRNA","P58682",1753,0,"Toll-like receptor 8","SPBC19C7.03_1",57,{"v":6e-07,"d":"6.00E-07"},"COG4886","pfam01582","TIR","TIR domain. The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.","GO:0001932|regulation of protein phosphorylation;GO:0002224|toll-like receptor signaling pathway;GO:0002755|MyD88-dependent toll-like receptor signaling pathway;GO:0006954|inflammatory response;GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0009615|response to virus;GO:0032695|negative regulation of interleukin-12 production;GO:0032727|positive regulation of interferon-alpha production;GO:0032728|positive regulation of interferon-beta production;GO:0032729|positive regulation of interferon-gamma production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0034158|toll-like receptor 8 signaling pathway;GO:0045087|innate immune response;GO:0045089|positive regulation of innate immune response;GO:0051607|defense response to virus;GO:0071260|cellular response to mechanical stimulus;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0003677|DNA binding;GO:0003725|double-stranded RNA binding;GO:0003727|single-stranded RNA binding;GO:0003953|NAD+ nucleosidase activity;GO:0004888|transmembrane signaling receptor activity;GO:0038187|pattern recognition receptor activity;GO:0042802|identical protein binding;","K10170","TLR8, CD288; toll-like receptor 8"]
["ENSRNOG00000034025",525,44.17101604,254,16.3399313,2.703255921,1.434698101,{"v":1.6e-41,"d":"1.60E-41"},{"v":9.3e-41,"d":"9.30E-41"},"up","yes","Ptprj","protein_coding","chr3:76405927-76562260:-","gi|309243082|ref|NP_058965.2|",6546,0,"receptor-type tyrosine-protein phosphatase eta [Rattus norvegicus]","gi|309243081|ref|NM_017269.2|",7449,0,"Rattus norvegicus protein tyrosine phosphatase, receptor type, J (Ptprj), mRNA","Q64455",2083,0,"Receptor-type tyrosine-protein phosphatase eta","SPAC11E3.09",151,{"v":2e-38,"d":"2.00E-38"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0001570|vasculogenesis;GO:0001954|positive regulation of cell-matrix adhesion;GO:0006470|protein dephosphorylation;GO:0007507|heart development;GO:0007596|blood coagulation;GO:0008285|negative regulation of cell proliferation;GO:0010572|positive regulation of platelet activation;GO:0010642|negative regulation of platelet-derived growth factor receptor signaling pathway;GO:0010759|positive regulation of macrophage chemotaxis;GO:0030155|regulation of cell adhesion;GO:0030183|B cell differentiation;GO:0030308|negative regulation of cell growth;GO:0030336|negative regulation of cell migration;GO:0032760|positive regulation of tumor necrosis factor production;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0035584|calcium-mediated signaling using intracellular calcium source;GO:0042059|negative regulation of epidermal growth factor receptor signaling pathway;GO:0042593|glucose homeostasis;GO:0043116|negative regulation of vascular permeability;GO:0043407|negative regulation of MAP kinase activity;GO:0043410|positive regulation of MAPK cascade;GO:0045785|positive regulation of cell adhesion;GO:0046627|negative regulation of insulin receptor signaling pathway;GO:0048008|platelet-derived growth factor receptor signaling pathway;GO:0048709|oligodendrocyte differentiation;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050860|negative regulation of T cell receptor signaling pathway;GO:0050918|positive chemotaxis;GO:0051894|positive regulation of focal adhesion assembly;GO:0051897|positive regulation of protein kinase B signaling;GO:0051898|negative regulation of protein kinase B signaling;GO:1905451|positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis;GO:1990264|peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity;GO:2000272|negative regulation of signaling receptor activity;","GO:0001772|immunological synapse;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0032587|ruffle membrane;","GO:0004725|protein tyrosine phosphatase activity;GO:0005161|platelet-derived growth factor receptor binding;GO:0008013|beta-catenin binding;GO:0016791|phosphatase activity;GO:0019901|protein kinase binding;GO:0045295|gamma-catenin binding;GO:0045296|cadherin binding;GO:0051019|mitogen-activated protein kinase binding;GO:0070097|delta-catenin binding;","K05698","PTPRJ, DEP1, CD148; receptor-type tyrosine-protein phosphatase eta [EC:3.1.3.48]"]
["ENSRNOG00000006932",311,26.16606855,96,6.175722066,4.236924569,2.083017444,{"v":2.03e-41,"d":"2.03E-41"},1.17E-40,"up","yes","AABR07029272.1","protein_coding","chr10:18827239-19244808:-","gi|117553625|ref|NP_203538.2|",9396,0,"dedicator of cytokinesis protein 2 [Mus musculus]","gi|459683823|ref|NM_033374.3|",4788,0,"Mus musculus dedicator of cyto-kinesis 2 (Dock2), mRNA","Q8C3J5",3619,0,"Dedicator of cytokinesis protein 2",".",".",".",".","pfam14429","DOCK-C2","C2 domain in Dock180 and Zizimin proteins. The Dock180/Dock1 and Zizimin proteins are atypical GTP/GDP exchange factors for the small GTPases Rac and Cdc42 and are implicated cell-migration and phagocytosis. Across all Dock180 proteins, two regions are conserved: C-terminus termed CZH2 or DHR2 (or the Dedicator of cytokinesis) whereas CZH1/DHR1 contain a new family of the C2 domain.",".",".",".",".","."]
["ENSRNOG00000031890",320,26.92328597,102,6.561704695,4.103093208,2.036711928,{"v":2.1e-41,"d":"2.10E-41"},{"v":1.21e-40,"d":"1.21E-40"},"up","yes","Ncam1","protein_coding","chr8:49865633-50166014:-","gi|564363529|ref|XP_006243050.1|",4997,0,"PREDICTED: neural cell adhesion molecule 1 isoform X5 [Rattus norvegicus]","gi|672061763|ref|XM_006242988.2|",3673,0,"PREDICTED: Rattus norvegicus neural cell adhesion molecule 1 (Ncam1), transcript variant X5, mRNA","P13595",1911,0,"Neural cell adhesion molecule 1",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0001928|regulation of exocyst assembly;GO:0007155|cell adhesion;GO:0007166|cell surface receptor signaling pathway;GO:0007413|axonal fasciculation;GO:0007420|brain development;GO:0007568|aging;GO:0007611|learning or memory;GO:0009410|response to xenobiotic stimulus;GO:0010035|response to inorganic substance;GO:0010288|response to lead ion;GO:0014012|peripheral nervous system axon regeneration;GO:0014823|response to activity;GO:0016338|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;GO:0021794|thalamus development;GO:0031100|animal organ regeneration;GO:0031175|neuron projection development;GO:0033555|multicellular organismal response to stress;GO:0034109|homotypic cell-cell adhesion;GO:0042220|response to cocaine;GO:0048666|neuron development;GO:0050804|modulation of chemical synaptic transmission;GO:0050850|positive regulation of calcium-mediated signaling;GO:0051930|regulation of sensory perception of pain;GO:0060045|positive regulation of cardiac muscle cell proliferation;GO:0060548|negative regulation of cell death;GO:0071219|cellular response to molecule of bacterial origin;GO:0071241|cellular response to inorganic substance;GO:0071679|commissural neuron axon guidance;GO:2001260|regulation of semaphorin-plexin signaling pathway;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0030426|growth cone;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098978|glutamatergic synapse;GO:0099055|integral component of postsynaptic membrane;GO:0099056|integral component of presynaptic membrane;","GO:0005104|fibroblast growth factor receptor binding;GO:0005515|protein binding;GO:0008092|cytoskeletal protein binding;GO:0008201|heparin binding;GO:0019902|phosphatase binding;GO:0030275|LRR domain binding;","K06491","NCAM, CD56; neural cell adhesion molecule"]
["ENSRNOG00000062487",523,44.0027455,253,16.27560086,2.703601906,1.434882736,{"v":2.23e-41,"d":"2.23E-41"},1.28E-40,"up","yes","ENSRNOG00000062487","protein_coding","chr20:4870851-4906450:-","gi|829760817|ref|XP_012619031.1|",369,{"v":5e-66,"d":"5.00E-66"},"PREDICTED: LOW QUALITY PROTEIN: saoe class I histocompatibility antigen, A alpha chain-like [Microcebus murinus]","gi|46237532|emb|BX883042.1|",1179,0,"Rattus norvegicus chromosome 20, major histocompatibility complex, assembled from 40 BACs, strain Brown Norway (BN/ssNHsd), RT1n haplotype; segment 1/11","P16391",171,{"v":5e-47,"d":"5.00E-47"},"RT1 class I histocompatibility antigen, AA alpha chain",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.",".",".",".",".","."]
["ENSRNOG00000033256",276,23.22133415,74,4.760452426,4.877967905,2.286280266,{"v":2.83e-41,"d":"2.83E-41"},1.62E-40,"up","yes","ENSRNOG00000033256","protein_coding","chr8:20078639-20095696:+","gi|564362687|ref|XP_006242736.1|",1017,{"v":2e-133,"d":"2.00E-133"},"PREDICTED: protein HIDE1 isoform X3 [Rattus norvegicus]","gi|157819996|ref|NM_001109624.1|",1301,0,"Rattus norvegicus hypothetical protein LOC691141 (LOC691141), mRNA","Q75VT8",300,{"v":3E-98,"d":"3.00E-98"},"Protein HIDE1",".",".",".",".","pfam15242","FAM53","Family of FAM53. The FAM53 protein family refers to a family of proteins, which bind to a transcriptional regulator that modulates cell proliferation. It is known to be highly important in neural tube development. It is found in eukaryotes and is typically between 303 and 413 amino acids in length.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000003172",848,71.34670781,536,34.48111487,2.069153161,1.049040439,{"v":5.23e-41,"d":"5.23E-41"},{"v":2.99e-40,"d":"2.99E-40"},"up","yes","Serpinf1","protein_coding","chr10:60249708-60262646:-","gi|29293811|ref|NP_808788.1|",1981,0,"pigment epithelium-derived factor precursor [Rattus norvegicus]","gi|31342661|ref|NM_177927.2|",1338,0,"Rattus norvegicus serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 (Serpinf1), mRNA","P97298",724,0,"Pigment epithelium-derived factor","all0778",129,{"v":1e-31,"d":"1.00E-31"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0001822|kidney development;GO:0007568|aging;GO:0007614|short-term memory;GO:0010447|response to acidic pH;GO:0010596|negative regulation of endothelial cell migration;GO:0010629|negative regulation of gene expression;GO:0010951|negative regulation of endopeptidase activity;GO:0010976|positive regulation of neuron projection development;GO:0014070|response to organic cyclic compound;GO:0016525|negative regulation of angiogenesis;GO:0042698|ovulation cycle;GO:0046685|response to arsenic-containing substance;GO:0050728|negative regulation of inflammatory response;GO:0050769|positive regulation of neurogenesis;GO:0060041|retina development in camera-type eye;GO:0060770|negative regulation of epithelial cell proliferation involved in prostate gland development;GO:0071279|cellular response to cobalt ion;GO:0071300|cellular response to retinoic acid;GO:0071333|cellular response to glucose stimulus;GO:0071549|cellular response to dexamethasone stimulus;GO:1901215|negative regulation of neuron death;GO:1901652|response to peptide;","GO:0005576|extracellular region;GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0030424|axon;GO:0043025|neuronal cell body;GO:0043203|axon hillock;GO:0048471|perinuclear region of cytoplasm;","GO:0004867|serine-type endopeptidase inhibitor activity;","K19614","SERPINF1, PEDF; pigment epithelium-derived factor"]
["ENSRNOG00000047349",152,12.78856083,9,0.578973944,22.08831844,4.465211687,{"v":9.08e-41,"d":"9.08E-41"},{"v":5.15e-40,"d":"5.15E-40"},"up","yes","Ms4a6b","protein_coding","chr1:208291950-208301843:+","gi|293344625|ref|XP_001075462.2|",1117,{"v":4e-151,"d":"4.00E-151"},"PREDICTED: membrane-spanning 4-domains subfamily A member 6B [Rattus norvegicus]","gi|672014687|ref|XM_008774778.1|",915,0,"PREDICTED: Rattus norvegicus membrane-spanning 4-domains, subfamily A, member 6B (Ms4a6b), transcript variant X3, mRNA","Q99N09",323,{"v":8e-109,"d":"8.00E-109"},"Membrane-spanning 4-domains subfamily A member 6B",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.",".",".",".",".","."]
["ENSRNOG00000008015",780,65.62550954,476,30.62128858,2.143133506,1.099721725,{"v":9.65e-41,"d":"9.65E-41"},{"v":5.46e-40,"d":"5.46E-40"},"up","yes","Fos","protein_coding","chr6:105121170-105124036:+","gi|63147420|ref|NP_071533.1|",1595,0,"proto-oncogene c-Fos [Rattus norvegicus]","gi|148298807|ref|NM_022197.2|",1589,0,"Rattus norvegicus FBJ osteosarcoma oncogene (Fos), mRNA","P12841",619,0,"Proto-oncogene c-Fos",".",".",".",".","pfam07716","bZIP_2","Basic region leucine zipper.","GO:0001661|conditioned taste aversion;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006366|transcription by RNA polymerase II;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0007399|nervous system development;GO:0007565|female pregnancy;GO:0007568|aging;GO:0009409|response to cold;GO:0009410|response to xenobiotic stimulus;GO:0009416|response to light stimulus;GO:0009612|response to mechanical stimulus;GO:0009629|response to gravity;GO:0009636|response to toxic substance;GO:0010468|regulation of gene expression;GO:0014070|response to organic cyclic compound;GO:0030431|sleep;GO:0031668|cellular response to extracellular stimulus;GO:0032496|response to lipopolysaccharide;GO:0032570|response to progesterone;GO:0032870|cellular response to hormone stimulus;GO:0034097|response to cytokine;GO:0034614|cellular response to reactive oxygen species;GO:0035902|response to immobilization stress;GO:0035914|skeletal muscle cell differentiation;GO:0035994|response to muscle stretch;GO:0045672|positive regulation of osteoclast differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051412|response to corticosterone;GO:0051591|response to cAMP;GO:0060395|SMAD protein signal transduction;GO:0071276|cellular response to cadmium ion;GO:0071277|cellular response to calcium ion;GO:1901216|positive regulation of neuron death;GO:1902895|positive regulation of pri-miRNA transcription by RNA polymerase II;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;GO:0016020|membrane;GO:0032993|protein-DNA complex;GO:0035976|transcription factor AP-1 complex;GO:0043005|neuron projection;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000979|RNA polymerase II core promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003690|double-stranded DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0005515|protein binding;GO:0042802|identical protein binding;GO:0043565|sequence-specific DNA binding;GO:0044877|protein-containing complex binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;GO:0070412|R-SMAD binding;GO:1990837|sequence-specific double-stranded DNA binding;","K04379","FOS; proto-oncogene protein c-fos"]
["ENSRNOG00000005214",261,21.95930512,67,4.310139358,5.09480165,2.349025981,2.34E-40,{"v":1.31e-39,"d":"1.31E-39"},"up","yes","Plek","protein_coding","chr14:91397019-91454131:-","gi|71043674|ref|NP_001020921.1|",1517,0,"pleckstrin [Rattus norvegicus]","gi|71043673|ref|NM_001025750.1|",1056,0,"Rattus norvegicus pleckstrin (Plek), mRNA","Q4KM33",588,0,"Pleckstrin",".",".",".",".","pfam00169","PH","PH domain. PH stands for pleckstrin homology.","GO:0002244|hematopoietic progenitor cell differentiation;GO:0002576|platelet degranulation;GO:0006904|vesicle docking involved in exocytosis;GO:0007229|integrin-mediated signaling pathway;GO:0010572|positive regulation of platelet activation;GO:0010920|negative regulation of inositol phosphate biosynthetic process;GO:0010925|positive regulation of inositol-polyphosphate 5-phosphatase activity;GO:0030030|cell projection organization;GO:0030836|positive regulation of actin filament depolymerization;GO:0030845|phospholipase C-inhibiting G protein-coupled receptor signaling pathway;GO:0030866|cortical actin cytoskeleton organization;GO:0031529|ruffle organization;GO:0031532|actin cytoskeleton reorganization;GO:0032233|positive regulation of actin filament bundle assembly;GO:0033625|positive regulation of integrin activation;GO:0035556|intracellular signal transduction;GO:0045744|negative regulation of G protein-coupled receptor signaling pathway;GO:0046488|phosphatidylinositol metabolic process;GO:0060305|regulation of cell diameter;GO:0070493|thrombin-activated receptor signaling pathway;GO:0070527|platelet aggregation;GO:0070528|protein kinase C signaling;GO:0070560|protein secretion by platelet;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0032587|ruffle membrane;","GO:0005080|protein kinase C binding;GO:0042803|protein homodimerization activity;GO:0043325|phosphatidylinositol-3,4-bisphosphate binding;","K19993","PLEK; pleckstrin"]
["ENSRNOG00000013304",233,19.60351759,51,3.280852347,5.975129484,2.578969977,{"v":4.12e-40,"d":"4.12E-40"},{"v":2.3e-39,"d":"2.30E-39"},"up","yes","Arg1","protein_coding","chr1:20475968-20488422:+","gi|149032924|gb|EDL87779.1|",1730,0,"arginase 1, isoform CRA_b [Rattus norvegicus]","gi|402692216|ref|NM_017134.3|",1507,0,"Rattus norvegicus arginase 1 (Arg1), mRNA","P07824",657,0,"Arginase-1","SPBP26C9.02c",239,{"v":4E-73,"d":"4.00E-73"},"COG0010","pfam00491","Arginase","Arginase family.","GO:0000050|urea cycle;GO:0001889|liver development;GO:0001938|positive regulation of endothelial cell proliferation;GO:0002250|adaptive immune response;GO:0006525|arginine metabolic process;GO:0007565|female pregnancy;GO:0007568|aging;GO:0009410|response to xenobiotic stimulus;GO:0009611|response to wounding;GO:0009635|response to herbicide;GO:0010042|response to manganese ion;GO:0010043|response to zinc ion;GO:0010269|response to selenium ion;GO:0010963|regulation of L-arginine import;GO:0014075|response to amine;GO:0019547|arginine catabolic process to ornithine;GO:0030324|lung development;GO:0032496|response to lipopolysaccharide;GO:0032964|collagen biosynthetic process;GO:0033189|response to vitamin A;GO:0033197|response to vitamin E;GO:0042130|negative regulation of T cell proliferation;GO:0042832|defense response to protozoan;GO:0043200|response to amino acid;GO:0043434|response to peptide hormone;GO:0045087|innate immune response;GO:0046007|negative regulation of activated T cell proliferation;GO:0046686|response to cadmium ion;GO:0048545|response to steroid hormone;GO:0048678|response to axon injury;GO:0051597|response to methylmercury;GO:0060056|mammary gland involution;GO:0060135|maternal process involved in female pregnancy;GO:0060336|negative regulation of interferon-gamma-mediated signaling pathway;GO:0070301|cellular response to hydrogen peroxide;GO:0070965|positive regulation of neutrophil mediated killing of fungus;GO:0071222|cellular response to lipopolysaccharide;GO:0071353|cellular response to interleukin-4;GO:0071377|cellular response to glucagon stimulus;GO:0071549|cellular response to dexamethasone stimulus;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:2000552|negative regulation of T-helper 2 cell cytokine production;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005741|mitochondrial outer membrane;GO:0005829|cytosol;GO:0043005|neuron projection;GO:0043025|neuronal cell body;","GO:0004053|arginase activity;GO:0030145|manganese ion binding;GO:0042802|identical protein binding;","K01476","E3.5.3.1, rocF, arg; arginase [EC:3.5.3.1]"]
["ENSRNOG00000042686",714,60.07258181,422,27.14744491,2.212826364,1.14589025,{"v":6.91e-40,"d":"6.91E-40"},{"v":3.82e-39,"d":"3.82E-39"},"up","yes","Trim34","protein_coding","chr1:158707172-158718674:+","gi|451770402|ref|NP_001263420.1|",2562,0,"tripartite motif-containing protein 34 [Rattus norvegicus]","gi|451770401|ref|NM_001276491.1|",2566,0,"Rattus norvegicus tripartite motif-containing 34 (Trim34), mRNA","Q99PP6",847,0,"Tripartite motif-containing protein 34A",".",".",".",".","pfam00622","SPRY","SPRY domain. SPRY Domain is named from SPla and the RYanodine Receptor. Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.","GO:0000209|protein polyubiquitination;GO:0010468|regulation of gene expression;GO:0010508|positive regulation of autophagy;GO:0016567|protein ubiquitination;GO:0032880|regulation of protein localization;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045087|innate immune response;GO:0046596|regulation of viral entry into host cell;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051092|positive regulation of NF-kappaB transcription factor activity;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0008270|zinc ion binding;GO:0019901|protein kinase binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0061630|ubiquitin protein ligase activity;","K11999","TRIM6_22_34; tripartite motif-containing protein 6/22/34"]
["ENSRNOG00000060665",699,58.81055278,409,26.31114922,2.235195137,1.160400787,{"v":7.61e-40,"d":"7.61E-40"},{"v":4.2e-39,"d":"4.20E-39"},"up","yes","Afap1","protein_coding","chr14:74743320-74856263:-","gi|672076537|ref|XP_008768469.1|",3377,0,"PREDICTED: actin filament-associated protein 1 isoform X3 [Rattus norvegicus]","gi|672076536|ref|XM_008770247.1|",3245,0,"PREDICTED: Rattus norvegicus actin filament associated protein 1 (Afap1), transcript variant X3, mRNA","Q80YS6",833,0,"Actin filament-associated protein 1",".",".",".",".","pfam00169","PH","PH domain. PH stands for pleckstrin homology.","GO:0007165|signal transduction;GO:0009966|regulation of signal transduction;GO:0051493|regulation of cytoskeleton organization;GO:0071260|cellular response to mechanical stimulus;","GO:0005829|cytosol;GO:0005884|actin filament;GO:0005925|focal adhesion;GO:0015629|actin cytoskeleton;","GO:0003779|actin binding;GO:0005515|protein binding;GO:0017124|SH3 domain binding;GO:0042169|SH2 domain binding;","K18616","AFAP1; actin filament associated protein 1"]
["ENSRNOG00000059207",141,11.86307288,5,0.321652191,36.88167907,5.204832432,{"v":8.29e-40,"d":"8.29E-40"},{"v":4.57e-39,"d":"4.57E-39"},"up","yes","Oas3","protein_coding","chr12:35779022-35802781:+","gi|57222314|ref|NP_001009493.1|",5928,0,"2'-5'-oligoadenylate synthase 3 [Rattus norvegicus]","gi|57222313|ref|NM_001009493.1|",4003,0,"Rattus norvegicus 2'-5'-oligoadenylate synthetase 3 (Oas3), mRNA","Q5MYT7",2288,0,"2'-5'-oligoadenylate synthase 3",".",".",".",".","pfam10421","OAS1_C","2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus. This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between 320 and 344 at the extreme C-terminal end. Oligoadenylate synthetases are antiviral enzymes that counteract vial attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesize 2'.5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication. This domain is often associated with NTP_transf_2 pfam01909.","GO:0009615|response to virus;GO:0032728|positive regulation of interferon-beta production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0035395|negative regulation of chemokine (C-X-C motif) ligand 9 production;GO:0039529|RIG-I signaling pathway;GO:0039530|MDA-5 signaling pathway;GO:0042742|defense response to bacterium;GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0051607|defense response to virus;GO:0060339|negative regulation of type I interferon-mediated signaling pathway;GO:0060700|regulation of ribonuclease activity;GO:0071639|positive regulation of monocyte chemotactic protein-1 production;GO:0071650|negative regulation of chemokine (C-C motif) ligand 5 production;GO:0071659|negative regulation of IP-10 production;GO:2000342|negative regulation of chemokine (C-X-C motif) ligand 2 production;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016020|membrane;","GO:0001730|2'-5'-oligoadenylate synthetase activity;GO:0003725|double-stranded RNA binding;GO:0005524|ATP binding;GO:0046872|metal ion binding;","K14216","OAS; 2'-5'-oligoadenylate synthetase [EC:2.7.7.84]"]
["ENSRNOG00000009822",199,16.74291846,34,2.187234898,7.654833266,2.936370954,2.83E-39,1.54E-38,"up","yes","Tlr2","protein_coding","chr2:169197419-169206630:-","gi|672042714|ref|XP_008759324.1|",3768,0,"PREDICTED: toll-like receptor 2 isoform X1 [Rattus norvegicus]","gi|672042713|ref|XM_008761102.1|",3103,0,"PREDICTED: Rattus norvegicus toll-like receptor 2 (Tlr2), transcript variant X1, mRNA","Q9QUN7",1299,0,"Toll-like receptor 2",".",".",".",".","pfam01582","TIR","TIR domain. The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.","GO:0001666|response to hypoxia;GO:0001774|microglial cell activation;GO:0001775|cell activation;GO:0001819|positive regulation of cytokine production;GO:0002224|toll-like receptor signaling pathway;GO:0002238|response to molecule of fungal origin;GO:0002687|positive regulation of leukocyte migration;GO:0002730|regulation of dendritic cell cytokine production;GO:0002752|cell surface pattern recognition receptor signaling pathway;GO:0002755|MyD88-dependent toll-like receptor signaling pathway;GO:0006691|leukotriene metabolic process;GO:0006952|defense response;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007252|I-kappaB phosphorylation;GO:0007612|learning;GO:0008285|negative regulation of cell proliferation;GO:0009617|response to bacterium;GO:0009636|response to toxic substance;GO:0010628|positive regulation of gene expression;GO:0014005|microglia development;GO:0030177|positive regulation of Wnt signaling pathway;GO:0030837|negative regulation of actin filament polymerization;GO:0032289|central nervous system myelin formation;GO:0032493|response to bacterial lipoprotein;GO:0032494|response to peptidoglycan;GO:0032496|response to lipopolysaccharide;GO:0032570|response to progesterone;GO:0032695|negative regulation of interleukin-12 production;GO:0032700|negative regulation of interleukin-17 production;GO:0032722|positive regulation of chemokine production;GO:0032728|positive regulation of interferon-beta production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032733|positive regulation of interleukin-10 production;GO:0032735|positive regulation of interleukin-12 production;GO:0032741|positive regulation of interleukin-18 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032868|response to insulin;GO:0034123|positive regulation of toll-like receptor signaling pathway;GO:0034134|toll-like receptor 2 signaling pathway;GO:0042495|detection of triacyl bacterial lipopeptide;GO:0042496|detection of diacyl bacterial lipopeptide;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046209|nitric oxide metabolic process;GO:0048714|positive regulation of oligodendrocyte differentiation;GO:0050729|positive regulation of inflammatory response;GO:0050765|negative regulation of phagocytosis;GO:0050830|defense response to Gram-positive bacterium;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051607|defense response to virus;GO:0051770|positive regulation of nitric-oxide synthase biosynthetic process;GO:0051964|negative regulation of synapse assembly;GO:0060907|positive regulation of macrophage cytokine production;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070542|response to fatty acid;GO:0071221|cellular response to bacterial lipopeptide;GO:0071223|cellular response to lipoteichoic acid;GO:0071224|cellular response to peptidoglycan;GO:0071346|cellular response to interferon-gamma;GO:0071726|cellular response to diacyl bacterial lipopeptide;GO:0071727|cellular response to triacyl bacterial lipopeptide;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1903974|positive regulation of cellular response to macrophage colony-stimulating factor stimulus;GO:1904417|positive regulation of xenophagy;GO:1904466|positive regulation of matrix metallopeptidase secretion;","GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0030670|phagocytic vesicle membrane;GO:0031226|intrinsic component of plasma membrane;GO:0035354|Toll-like receptor 1-Toll-like receptor 2 protein complex;GO:0035355|Toll-like receptor 2-Toll-like receptor 6 protein complex;GO:0042995|cell projection;GO:0044297|cell body;GO:0045121|membrane raft;","GO:0001530|lipopolysaccharide binding;GO:0001540|amyloid-beta binding;GO:0003953|NAD+ nucleosidase activity;GO:0004888|transmembrane signaling receptor activity;GO:0005515|protein binding;GO:0035325|Toll-like receptor binding;GO:0038023|signaling receptor activity;GO:0038187|pattern recognition receptor activity;GO:0042497|triacyl lipopeptide binding;GO:0042498|diacyl lipopeptide binding;GO:0042802|identical protein binding;GO:0042834|peptidoglycan binding;GO:0044877|protein-containing complex binding;GO:0070891|lipoteichoic acid binding;GO:0071723|lipopeptide binding;","K10159","TLR2, CD282; toll-like receptor 2"]
["ENSRNOG00000057058",406,34.15891907,171,11.00050493,3.105213741,1.634692577,{"v":5.28e-39,"d":"5.28E-39"},{"v":2.86e-38,"d":"2.86E-38"},"up","yes","Cd300a","protein_coding","chr10:99929801-99942674:+","gi|329112553|ref|NP_001192277.1|",1401,0,"CMRF35-like molecule 8 precursor [Rattus norvegicus]","gi|329112552|ref|NM_001205348.1|",1514,0,"Rattus norvegicus Cd300a molecule (Cd300a), mRNA","A2TGX5",538,0,"CMRF35-like molecule 8",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0002552|serotonin secretion by mast cell;GO:0006898|receptor-mediated endocytosis;GO:0014063|negative regulation of serotonin secretion;GO:0030889|negative regulation of B cell proliferation;GO:0032516|positive regulation of phosphoprotein phosphatase activity;GO:0033007|negative regulation of mast cell activation involved in immune response;GO:0034125|negative regulation of MyD88-dependent toll-like receptor signaling pathway;GO:0043305|negative regulation of mast cell degranulation;GO:0043407|negative regulation of MAP kinase activity;GO:0048147|negative regulation of fibroblast proliferation;GO:0050856|regulation of T cell receptor signaling pathway;GO:0050859|negative regulation of B cell receptor signaling pathway;GO:0051134|negative regulation of NK T cell activation;GO:0060101|negative regulation of phagocytosis, engulfment;GO:1902564|negative regulation of neutrophil activation;GO:1902567|negative regulation of eosinophil activation;GO:1902569|negative regulation of activation of Janus kinase activity;GO:2000417|negative regulation of eosinophil migration;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0001786|phosphatidylserine binding;GO:0004888|transmembrane signaling receptor activity;GO:0008429|phosphatidylethanolamine binding;GO:0019902|phosphatase binding;GO:0038023|signaling receptor activity;","K06719","CD300; CD300 antigen"]
["ENSRNOG00000005378",170,14.30299567,20,1.286608764,11.11681816,3.474672016,{"v":5.35e-39,"d":"5.35E-39"},{"v":2.9e-38,"d":"2.90E-38"},"up","yes","Gna15","protein_coding","chr7:8184861-8205508:+","gi|149034406|gb|EDL89143.1|",1864,0,"guanine nucleotide binding protein, alpha 15 [Rattus norvegicus]","gi|672057901|ref|XM_006241021.2|",1799,0,"PREDICTED: Rattus norvegicus guanine nucleotide binding protein, alpha 15 (Gna15), transcript variant X1, mRNA","O88302",721,0,"Guanine nucleotide-binding protein subunit alpha-15",".",".",".",".","pfam00503","G-alpha","G-protein alpha subunit. G proteins couple receptors of extracellular signals to intracellular signaling pathways. The G protein alpha subunit binds guanyl nucleotide and is a weak GTPase. A set of residues that are unique to G-alpha as compared to its ancestor the Arf-like family form a ring of residues centered on the nucleotide binding site. A Ggamma is found fused to an inactive Galpha in the Dictyostelium protein gbqA.","GO:0001508|action potential;GO:0007188|adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0051482|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway;GO:0060158|phospholipase C-activating dopamine receptor signaling pathway;","GO:0005834|heterotrimeric G-protein complex;GO:0016020|membrane;","GO:0001664|G protein-coupled receptor binding;GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0019001|guanyl nucleotide binding;GO:0031683|G-protein beta/gamma-subunit complex binding;GO:0046872|metal ion binding;","K04637","GNA15; guanine nucleotide-binding protein subunit alpha-15"]
["ENSRNOG00000030467",281,23.64201049,83,5.339426369,4.427818431,2.146596064,{"v":5.54e-39,"d":"5.54E-39"},{"v":3e-38,"d":"3.00E-38"},"up","yes","Ube2l6","protein_coding","chr3:69873424-69888048:+","gi|67078502|ref|NP_001019926.1|",767,{"v":3e-99,"d":"3.00E-99"},"ubiquitin/ISG15-conjugating enzyme E2 L6 [Rattus norvegicus]","gi|67078501|ref|NM_001024755.1|",928,0,"Rattus norvegicus ubiquitin-conjugating enzyme E2L 6 (Ube2l6), mRNA","Q4V8J2",300,{"v":9e-101,"d":"9.00E-101"},"Ubiquitin/ISG15-conjugating enzyme E2 L6","YDR059c",89.4,{"v":1e-20,"d":"1.00E-20"},"COG5078","pfam00179","UQ_con","Ubiquitin-conjugating enzyme. Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. TSG101 is one of several UBC homologues that lacks this active site cysteine.","GO:0000209|protein polyubiquitination;GO:0006511|ubiquitin-dependent protein catabolic process;GO:0019941|modification-dependent protein catabolic process;GO:0032020|ISG15-protein conjugation;","GO:0000151|ubiquitin ligase complex;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0019787|ubiquitin-like protein transferase activity;GO:0031625|ubiquitin protein ligase binding;GO:0042296|ISG15 transferase activity;GO:0043130|ubiquitin binding;GO:0061631|ubiquitin conjugating enzyme activity;","K04553","UBE2L6, UBCH8; ubiquitin-conjugating enzyme E2 L6 [EC:2.3.2.23]"]
["ENSRNOG00000015577",511,42.99312228,256,16.46859218,2.610613088,1.384388656,{"v":2e-38,"d":"2.00E-38"},1.07E-37,"up","yes","Lpar6","protein_coding","chr15:48416544-48422331:+","gi|113951677|ref|NP_001039308.1|",1744,0,"lysophosphatidic acid receptor 6 [Rattus norvegicus]","gi|113951676|ref|NM_001045843.1|",1810,0,"Rattus norvegicus lysophosphatidic acid receptor 6 (Lpar6), mRNA","Q4G072",676,0,"Lysophosphatidic acid receptor 6",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001835|blastocyst hatching;GO:0035025|positive regulation of Rho protein signal transduction;GO:0051482|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;","GO:0004930|G protein-coupled receptor activity;GO:0070915|lysophosphatidic acid receptor activity;","K04273","LPAR6, P2RY5; lysophosphatidic acid receptor 6"]
["ENSRNOG00000056376",692,58.2216059,411,26.43981009,2.202043271,1.138842819,{"v":2.4e-38,"d":"2.40E-38"},{"v":1.28e-37,"d":"1.28E-37"},"up","yes","Dusp22","protein_coding","chr17:33780981-33831321:-","gi|564391295|ref|XP_006253951.1|",1006,{"v":5e-126,"d":"5.00E-126"},"PREDICTED: dual specificity protein phosphatase 22 isoform X2 [Rattus norvegicus]","gi|672081613|ref|XM_006253889.2|",3018,0,"PREDICTED: Rattus norvegicus dual specificity phosphatase 22 (Dusp22), transcript variant X2, mRNA","Q99N11",348,{"v":2e-111,"d":"2.00E-111"},"Dual specificity protein phosphatase 22","SPBC17A3.06",94,{"v":1e-19,"d":"1.00E-19"},"COG2453","pfam00782","DSPc","Dual specificity phosphatase, catalytic domain. Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a \"recognition\" region.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0002710|negative regulation of T cell mediated immunity;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0030336|negative regulation of cell migration;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0042127|regulation of cell proliferation;GO:0046330|positive regulation of JNK cascade;GO:0050860|negative regulation of T cell receptor signaling pathway;GO:0050868|negative regulation of T cell activation;GO:0051895|negative regulation of focal adhesion assembly;GO:0071364|cellular response to epidermal growth factor stimulus;GO:1903996|negative regulation of non-membrane spanning protein tyrosine kinase activity;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0031941|filamentous actin;GO:0061851|leading edge of lamellipodium;","GO:0004725|protein tyrosine phosphatase activity;GO:0004726|non-membrane spanning protein tyrosine phosphatase activity;GO:0008138|protein tyrosine/serine/threonine phosphatase activity;GO:1990782|protein tyrosine kinase binding;","K14165","K14165; atypical dual specificity phosphatase [EC:3.1.3.16 3.1.3.48]"]
["ENSRNOG00000069835",205,17.24773007,39,2.508887089,6.874653764,2.781287055,{"v":2.4e-38,"d":"2.40E-38"},{"v":1.28e-37,"d":"1.28E-37"},"up","yes","Oas1i","protein_coding","chr12:35624592-35636604:+","gi|57527337|ref|NP_001009680.1|",1808,0,"2 ' -5 ' oligoadenylate synthetase 1I [Rattus norvegicus]","gi|672073200|ref|XM_003751197.2|",1648,0,"PREDICTED: Rattus norvegicus 2'-5'-oligoadenylate synthase 1A-like (LOC100910735), mRNA","P11928",555,0,"2'-5'-oligoadenylate synthase 1A",".",".",".",".","pfam10421","OAS1_C","2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus. This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between 320 and 344 at the extreme C-terminal end. Oligoadenylate synthetases are antiviral enzymes that counteract vial attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesize 2'.5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication. This domain is often associated with NTP_transf_2 pfam01909.",".",".",".",".","."]
["ENSRNOG00000036829",439,36.93538294,199,12.8017572,2.885180711,1.528661684,{"v":2.71e-38,"d":"2.71E-38"},1.44E-37,"up","yes","Nckap1l","protein_coding","chr7:134577482-134622934:+","gi|672060100|ref|XP_008763975.1|",6060,0,"PREDICTED: nck-associated protein 1-like isoform X1 [Rattus norvegicus]","gi|672060099|ref|XM_008765753.1|",4650,0,"PREDICTED: Rattus norvegicus NCK associated protein 1 like (Nckap1l), transcript variant X1, mRNA","Q8K1X4",2302,0,"Nck-associated protein 1-like",".",".",".",".","pfam09735","Nckap1","Membrane-associated apoptosis protein. Expression of this protein was found to be markedly reduced in patients with Alzheimer's disease. It is involved in the regulation of actin polymerization in the brain as part of a WAVE2 signalling complex.","GO:0000902|cell morphogenesis;GO:0001782|B cell homeostasis;GO:0002262|myeloid cell homeostasis;GO:0002687|positive regulation of leukocyte migration;GO:0006935|chemotaxis;GO:0009410|response to xenobiotic stimulus;GO:0016477|cell migration;GO:0030011|maintenance of cell polarity;GO:0030031|cell projection assembly;GO:0030593|neutrophil chemotaxis;GO:0030838|positive regulation of actin filament polymerization;GO:0030866|cortical actin cytoskeleton organization;GO:0030890|positive regulation of B cell proliferation;GO:0032147|activation of protein kinase activity;GO:0032700|negative regulation of interleukin-17 production;GO:0032715|negative regulation of interleukin-6 production;GO:0033630|positive regulation of cell adhesion mediated by integrin;GO:0034101|erythrocyte homeostasis;GO:0035509|negative regulation of myosin-light-chain-phosphatase activity;GO:0042102|positive regulation of T cell proliferation;GO:0042327|positive regulation of phosphorylation;GO:0043029|T cell homeostasis;GO:0043066|negative regulation of apoptotic process;GO:0043318|negative regulation of cytotoxic T cell degranulation;GO:0043372|positive regulation of CD4-positive, alpha-beta T cell differentiation;GO:0043378|positive regulation of CD8-positive, alpha-beta T cell differentiation;GO:0045579|positive regulation of B cell differentiation;GO:0045588|positive regulation of gamma-delta T cell differentiation;GO:0045621|positive regulation of lymphocyte differentiation;GO:0045648|positive regulation of erythrocyte differentiation;GO:0048812|neuron projection morphogenesis;GO:0048821|erythrocyte development;GO:0050853|B cell receptor signaling pathway;GO:0060100|positive regulation of phagocytosis, engulfment;GO:0065003|protein-containing complex assembly;GO:0070358|actin polymerization-dependent cell motility;GO:0090023|positive regulation of neutrophil chemotaxis;GO:1902624|positive regulation of neutrophil migration;GO:1904515|positive regulation of TORC2 signaling;","GO:0005829|cytosol;GO:0031209|SCAR complex;","GO:0005096|GTPase activator activity;GO:0030295|protein kinase activator activity;GO:0044877|protein-containing complex binding;GO:1904841|TORC2 complex binding;","K05750","NCKAP1, NAP125; NCK-associated protein 1"]
["ENSRNOG00000012779",248,20.86554662,64,4.117148044,5.06796122,2.341405485,{"v":2.72e-38,"d":"2.72E-38"},1.45E-37,"up","yes","Msr1","protein_coding","chr16:52717732-52799676:+","gi|564389351|ref|XP_006253268.1|",2291,0,"PREDICTED: macrophage scavenger receptor types I and II isoform X1 [Rattus norvegicus]","gi|672080329|ref|XM_006253206.2|",1925,0,"PREDICTED: Rattus norvegicus macrophage scavenger receptor 1 (Msr1), transcript variant X1, mRNA","P30204",656,0,"Macrophage scavenger receptor types I and II",".",".",".",".","pfam00530","SRCR","Scavenger receptor cysteine-rich domain. These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.","GO:0006898|receptor-mediated endocytosis;GO:0006911|phagocytosis, engulfment;GO:0010629|negative regulation of gene expression;GO:0010744|positive regulation of macrophage derived foam cell differentiation;GO:0010886|positive regulation of cholesterol storage;GO:0030301|cholesterol transport;GO:0034381|plasma lipoprotein particle clearance;GO:0042953|lipoprotein transport;GO:0071407|cellular response to organic cyclic compound;GO:0097242|amyloid-beta clearance;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0031410|cytoplasmic vesicle;","GO:0001540|amyloid-beta binding;GO:0003674|molecular_function;GO:0005044|scavenger receptor activity;GO:0030169|low-density lipoprotein particle binding;GO:0038024|cargo receptor activity;","K06558","MSR1, CD204; macrophage scavenger receptor 1"]
["ENSRNOG00000012665",460,38.70222358,218,14.02403552,2.759706613,1.464514901,{"v":1.1E-37,"d":"1.10E-37"},{"v":5.78e-37,"d":"5.78E-37"},"up","yes","Nmrk1","protein_coding","chr1:216049437-216076791:+","gi|66730337|ref|NP_001019463.1|",1050,{"v":2e-138,"d":"2.00E-138"},"nicotinamide riboside kinase 1 [Rattus norvegicus]","gi|66730336|ref|NM_001024292.1|",1566,0,"Rattus norvegicus nicotinamide riboside kinase 1 (Nmrk1), mRNA","Q6AY91",409,{"v":7e-140,"d":"7.00E-140"},"Nicotinamide riboside kinase 1","SPBP22H7.06",71.2,{"v":3e-13,"d":"3.00E-13"},"COG0572","pfam13238","AAA_18","AAA domain.","GO:0008150|biological_process;GO:0009435|NAD biosynthetic process;GO:0016310|phosphorylation;","GO:0005575|cellular_component;GO:0005737|cytoplasm;","GO:0003674|molecular_function;GO:0005524|ATP binding;GO:0046872|metal ion binding;GO:0050262|ribosylnicotinamide kinase activity;GO:0061769|ribosylnicotinate kinase activity;","K10524","NRK1_2; nicotinamide/nicotinate riboside kinase [EC:2.7.1.22 2.7.1.173]"]
["ENSRNOG00000000569",562,47.28402098,302,19.42779233,2.433833972,1.283230756,{"v":1.21e-37,"d":"1.21E-37"},{"v":6.35e-37,"d":"6.35E-37"},"up","yes","Vsir","protein_coding","chr20:28281596-28303878:+","gi|564397877|ref|XP_006256488.1|",1504,0,"PREDICTED: platelet receptor Gi24 isoform X1 [Rattus norvegicus]","gi|672086369|ref|XM_006256426.2|",1895,0,"PREDICTED: Rattus norvegicus hypothetical protein LOC690899 (MGC112715), transcript variant X1, mRNA","Q9D659",483,{"v":7e-166,"d":"7.00E-166"},"V-type immunoglobulin domain-containing suppressor of T-cell activation",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.","GO:0002725|negative regulation of T cell cytokine production;GO:0010628|positive regulation of gene expression;GO:0010950|positive regulation of endopeptidase activity;GO:0030335|positive regulation of cell migration;GO:0030509|BMP signaling pathway;GO:0030513|positive regulation of BMP signaling pathway;GO:0031638|zymogen activation;GO:0032689|negative regulation of interferon-gamma production;GO:0032693|negative regulation of interleukin-10 production;GO:0032700|negative regulation of interleukin-17 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0045591|positive regulation of regulatory T cell differentiation;GO:0048863|stem cell differentiation;GO:0120158|positive regulation of collagen catabolic process;GO:2000562|negative regulation of CD4-positive, alpha-beta T cell proliferation;GO:2000565|negative regulation of CD8-positive, alpha-beta T cell proliferation;GO:2000738|positive regulation of stem cell differentiation;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0019899|enzyme binding;GO:0042802|identical protein binding;GO:0061133|endopeptidase activator activity;","K23268","VSIR, VISTA; V-type immunoglobulin domain-containing suppressor of T-cell activation"]
["ENSRNOG00000030689",212,17.83667695,45,2.894869718,6.161478301,2.623276533,{"v":2.6e-37,"d":"2.60E-37"},{"v":1.36e-36,"d":"1.36E-36"},"up","yes","Ms4a6bl","protein_coding","chr1:208153530-208174479:+","gi|564298878|ref|XP_002725833.2|",1081,{"v":2e-141,"d":"2.00E-141"},"PREDICTED: membrane-spanning 4-domains subfamily A member 6C-like isoform X3 [Rattus norvegicus]","gi|672014682|ref|XM_006223653.2|",794,0,"PREDICTED: Rattus norvegicus membrane-spanning 4-domains, subfamily A, member 6C (Ms4a6c), transcript variant X4, mRNA","Q99N08",305,{"v":4e-98,"d":"4.00E-98"},"Membrane-spanning 4-domains subfamily A member 6C",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.",".","GO:0016021|integral component of membrane;",".","K22191","MS4A5_6_7; membrane-spanning 4-domains subfamily A member 5/6/7"]
["ENSRNOG00000066399",761,64.02693944,480,30.87861033,2.073504564,1.052071223,{"v":3.82e-37,"d":"3.82E-37"},{"v":1.98e-36,"d":"1.98E-36"},"up","yes","ENSRNOG00000066399","lncRNA","chr1:246153662-246156548:-","gi|26349705|dbj|BAC38492.1|",251,{"v":4e-21,"d":"4.00E-21"},"unnamed protein product [Mus musculus]","gi|672040470|ref|XM_006231514.2|",2880,0,"PREDICTED: Rattus norvegicus SH3 and PX domains 2A (Sh3pxd2a), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam15483","DUF4641","Domain of unknown function (DUF4641). This family of proteins is found in eukaryotes. Proteins in this family are typically between 201 and 519 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000019854",240,20.19246448,62,3.988487167,5.062687587,2.33990346,{"v":4.37e-37,"d":"4.37E-37"},{"v":2.26e-36,"d":"2.26E-36"},"up","yes","Napsa","protein_coding","chr1:95064900-95077094:+","gi|13928928|ref|NP_113858.1|",2075,0,"napsin-A precursor [Rattus norvegicus]","gi|162135962|ref|NM_031670.2|",1306,0,"Rattus norvegicus napsin A aspartic peptidase (Napsa), mRNA","O09043",722,0,"Napsin-A",".",".",".",".","pfam00026","Asp","Eukaryotic aspartyl protease. Aspartyl (acid) proteases include pepsins, cathepsins, and renins. Two-domain structure, probably arising from ancestral duplication. This family does not include the retroviral nor retrotransposon proteases (pfam00077), which are much smaller and appear to be homologous to a single domain of the eukaryotic asp proteases.","GO:0033619|membrane protein proteolysis;GO:0043129|surfactant homeostasis;","GO:0005615|extracellular space;GO:0005764|lysosome;GO:0097208|alveolar lamellar body;","GO:0004175|endopeptidase activity;GO:0004190|aspartic-type endopeptidase activity;GO:0008233|peptidase activity;","K08565","NAPSA; napsin-A [EC:3.4.23.-]"]
["ENSRNOG00000048636",173,14.55540148,25,1.608260955,9.050397844,3.177981213,{"v":6.85e-37,"d":"6.85E-37"},3.52E-36,"up","yes","Il2rb","protein_coding","chr7:110033341-110048054:-","gi|564360935|ref|XP_006242032.1|",2407,0,"PREDICTED: interleukin-2 receptor subunit beta isoform X1 [Rattus norvegicus]","gi|672059844|ref|XM_006241970.2|",2553,0,"PREDICTED: Rattus norvegicus interleukin 2 receptor, beta (Il2rb), transcript variant X1, mRNA","P26896",894,0,"Interleukin-2 receptor subunit beta",".",".",".",".","pfam00041","fn3","Fibronectin type III domain.","GO:0019221|cytokine-mediated signaling pathway;GO:0030101|natural killer cell activation;GO:0035723|interleukin-15-mediated signaling pathway;GO:0038110|interleukin-2-mediated signaling pathway;GO:0043066|negative regulation of apoptotic process;GO:0050766|positive regulation of phagocytosis;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0004896|cytokine receptor activity;GO:0004911|interleukin-2 receptor activity;GO:0019976|interleukin-2 binding;GO:0042010|interleukin-15 receptor activity;","K05069","IL2RB, CD122; interleukin 2 receptor beta"]
["ENSRNOG00000015894",419,35.25267756,189,12.15845282,2.89943779,1.535773184,{"v":7.24e-37,"d":"7.24E-37"},{"v":3.71e-36,"d":"3.71E-36"},"up","yes","Dock8","protein_coding","chr1:222649309-222842474:+","gi|197927178|ref|NP_001032882.2|",10548,0,"dedicator of cytokinesis protein 8 [Rattus norvegicus]","gi|672040011|ref|XM_008760310.1|",7223,0,"PREDICTED: Rattus norvegicus dedicator of cytokinesis 8 (Dock8), transcript variant X3, mRNA","Q8C147",3985,0,"Dedicator of cytokinesis protein 8",".",".",".",".","pfam06920","Ded_cyto","Dedicator of cytokinesis. This family represents a conserved region approximately 200 residues long within a number of eukaryotic dedicator of cytokinesis proteins. These are potential guanine nucleotide exchange factors, which activate some small GTPases by exchanging bound GDP for free GTP.","GO:0001771|immunological synapse formation;GO:0007264|small GTPase mediated signal transduction;GO:0036336|dendritic cell migration;GO:0043547|positive regulation of GTPase activity;GO:0061485|memory T cell proliferation;GO:0070233|negative regulation of T cell apoptotic process;GO:1903905|positive regulation of establishment of T cell polarity;GO:1990869|cellular response to chemokine;GO:2000406|positive regulation of T cell migration;","GO:0005737|cytoplasm;GO:0031252|cell leading edge;GO:0031256|leading edge membrane;","GO:0005085|guanyl-nucleotide exchange factor activity;","K21852","DOCK6_7_8; dedicator of cytokinesis protein 6/7/8"]
["ENSRNOG00000066264",266,22.37998146,79,5.082104617,4.403683739,2.138710862,{"v":7.86e-37,"d":"7.86E-37"},{"v":4.02e-36,"d":"4.02E-36"},"up","yes","RGD1563400","protein_coding","chr12:18566837-18582202:-","gi|564323654|ref|XP_006227213.1|",1042,{"v":8e-130,"d":"8.00E-130"},"PREDICTED: paired immunoglobulin-like type 2 receptor beta-2 isoform X1 [Rattus norvegicus]","gi|672072478|ref|XM_008769083.1|",1467,0,"PREDICTED: Rattus norvegicus similar to paired immunoglobin-like type 2 receptor beta (RGD1563400), transcript variant X7, mRNA","Q2YFS2",289,{"v":4e-88,"d":"4.00E-88"},"Paired immunoglobulin-like type 2 receptor beta",".",".",".",".","pfam13871","Helicase_C_4","Helicase_C-like. Strawberry notch proteins carry DExD/H-box groups and Helicase_C domains. These proteins promote the expression of diverse targets, potentially through interactions with transcriptional activator or repressor complexes.",".",".",".",".","."]
["ENSRNOG00000014532",579,48.71432055,321,20.65007066,2.359038928,1.238199226,1.01E-36,5.18E-36,"up","yes","Lbp","protein_coding","chr3:146954015-146981586:+","gi|139948891|ref|NP_058904.2|",2400,0,"lipopolysaccharide-binding protein precursor [Rattus norvegicus]","gi|510714|gb|L32132.1|RATLPSBP",2389,0,"Rat lipopolysaccharide binding protein mRNA, complete cds","Q63313",924,0,"Lipopolysaccharide-binding protein",".",".",".",".","pfam02886","LBP_BPI_CETP_C","LBP / BPI / CETP family, C-terminal domain. The N and C terminal domains of the LBP/BPI/CETP family are structurally similar.","GO:0001889|liver development;GO:0002232|leukocyte chemotaxis involved in inflammatory response;GO:0002281|macrophage activation involved in immune response;GO:0006953|acute-phase response;GO:0015920|lipopolysaccharide transport;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0032490|detection of molecule of bacterial origin;GO:0032496|response to lipopolysaccharide;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032722|positive regulation of chemokine production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0033036|macromolecule localization;GO:0034145|positive regulation of toll-like receptor 4 signaling pathway;GO:0043032|positive regulation of macrophage activation;GO:0045087|innate immune response;GO:0045919|positive regulation of cytolysis;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:0060100|positive regulation of phagocytosis, engulfment;GO:0060265|positive regulation of respiratory burst involved in inflammatory response;GO:0071222|cellular response to lipopolysaccharide;GO:0071223|cellular response to lipoteichoic acid;GO:0090023|positive regulation of neutrophil chemotaxis;GO:0090559|regulation of membrane permeability;","GO:0005615|extracellular space;GO:0009986|cell surface;GO:0016020|membrane;","GO:0001530|lipopolysaccharide binding;GO:0005102|signaling receptor binding;GO:0070891|lipoteichoic acid binding;GO:0071723|lipopeptide binding;","K05399","LBP; lipopolysaccharide-binding protein"]
["ENSRNOG00000058545",382,32.13967262,163,10.48586142,3.065048385,1.615909849,{"v":3.19e-36,"d":"3.19E-36"},{"v":1.61e-35,"d":"1.61E-35"},"up","yes","ENSRNOG00000058545","protein_coding","chrX:151632454-151651128:-","gi|78486570|ref|NP_653341.2|",4443,0,"rho GTPase-activating protein 4 [Rattus norvegicus]","gi|53830690|gb|AY742900.1|",6946,0,"Rattus norvegicus Rho GTPase activating protein 4 (Arhgap4) mRNA, complete cds","P98171",1361,0,"Rho GTPase-activating protein 4",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007165|signal transduction;GO:0007399|nervous system development;GO:0010764|negative regulation of fibroblast migration;GO:0030336|negative regulation of cell migration;GO:0030517|negative regulation of axon extension;GO:0035023|regulation of Rho protein signal transduction;GO:0050790|regulation of catalytic activity;","GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005874|microtubule;GO:0030426|growth cone;","GO:0005096|GTPase activator activity;GO:0042802|identical protein binding;","K20122","ARHGAP4; Rho GTPase-activating protein 4"]
["ENSRNOG00000007439",461,38.78635885,225,14.47434859,2.679661789,1.422050924,{"v":3.3e-36,"d":"3.30E-36"},1.66E-35,"up","yes","Unc13d","protein_coding","chr10:101296776-101311687:-","gi|564375177|ref|XP_006247764.1|",5567,0,"PREDICTED: protein unc-13 homolog D isoform X1 [Rattus norvegicus]","gi|672069607|ref|XM_006247702.2|",4202,0,"PREDICTED: Rattus norvegicus unc-13 homolog D (C. elegans) (Unc13d), transcript variant X1, mRNA","Q9R189",2078,0,"Protein unc-13 homolog D",".",".",".",".","pfam10540","Membr_traf_MHD","Munc13 (mammalian uncoordinated) homology domain. Munc13 proteins constitute a family of three highly homologous molecules (Munc13-1, Munc13-2 and Munc13-3) with homology to Caenorhabditis elegans unc-13p. Munc13 proteins contain a phorbol ester-binding C1 domain and two C2 domains, which are Ca2+/phospholipid binding domains. Sequence analyses have uncovered two regions called Munc13 homology domains 1 (MHD1) and 2 (MHD2) that are arranged between two flanking C2 domains. MHD1 and MHD2 domains are present in a wide variety of proteins from Arabidopsis thaliana, C. elegans, Drosophila melanogaster, mouse, rat and human, some of which may function in a Munc13-like manner to regulate membrane trafficking. The MHD1 and MHD2 domains are predicted to be alpha-helical.","GO:0002432|granuloma formation;GO:0002467|germinal center formation;GO:0006887|exocytosis;GO:0006909|phagocytosis;GO:0043304|regulation of mast cell degranulation;GO:0043320|natural killer cell degranulation;GO:0045921|positive regulation of exocytosis;GO:0046903|secretion;GO:0051607|defense response to virus;GO:0061789|dense core granule priming;GO:1900026|positive regulation of substrate adhesion-dependent cell spreading;GO:1903307|positive regulation of regulated secretory pathway;","GO:0005575|cellular_component;GO:0005764|lysosome;GO:0005770|late endosome;GO:0005829|cytosol;GO:0016020|membrane;GO:0033093|Weibel-Palade body;GO:0043231|intracellular membrane-bounded organelle;GO:0055037|recycling endosome;GO:0070382|exocytic vesicle;","GO:0003674|molecular_function;GO:0031267|small GTPase binding;GO:0046872|metal ion binding;","K19728","UNC13D, MUNC13; protein unc-13 D"]
["ENSRNOG00000056783",125,10.51690858,3,0.192991315,54.49420667,5.768030959,{"v":7.78e-36,"d":"7.78E-36"},{"v":3.86e-35,"d":"3.86E-35"},"up","yes","Cd69","protein_coding","chr4:162725446-162733542:-","gi|61097910|ref|NP_599154.1|",873,{"v":6e-108,"d":"6.00E-108"},"early activation antigen CD69 [Rattus norvegicus]","gi|61097909|ref|NM_134327.1|",1474,0,"Rattus norvegicus Cd69 molecule (Cd69), mRNA","P37217",275,{"v":1E-84,"d":"1.00E-84"},"Early activation antigen CD69",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0001867|complement activation, lectin pathway;GO:0071466|cellular response to xenobiotic stimulus;","GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0032991|protein-containing complex;","GO:0005509|calcium ion binding;GO:0042802|identical protein binding;","K06502","CD69; CD69 antigen"]
["ENSRNOG00000060241",167,14.05058986,25,1.608260955,8.736511213,3.127057277,{"v":3.55e-35,"d":"3.55E-35"},{"v":1.74e-34,"d":"1.74E-34"},"up","yes","ENSRNOG00000060241","protein_coding","chr4:163837399-163865211:-","gi|162417946|ref|NP_001104780.1|",1370,0,"Ly49 inhibitory receptor-like [Rattus norvegicus]","gi|162417945|ref|NM_001111310.1|",1238,0,"Rattus norvegicus hypothetical protein LOC497796 (LOC497796), mRNA","P20937",326,{"v":3e-108,"d":"3.00E-108"},"T-cell surface glycoprotein YE1/48",".",".",".",".","pfam08391","Ly49","Ly49-like protein, N-terminal region. The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000011557",139,11.69480234,12,0.771965258,15.14938945,3.921187747,{"v":5.69e-35,"d":"5.69E-35"},{"v":2.78e-34,"d":"2.78E-34"},"up","yes","S100a8","protein_coding","chr2:176167124-176167643:+","gi|281485600|ref|NP_446274.2|",470,{"v":2e-58,"d":"2.00E-58"},"protein S100-A8 [Rattus norvegicus]","gi|672042842|ref|XM_006232565.2|",355,0,"PREDICTED: Rattus norvegicus S100 calcium binding protein A8 (S100a8), transcript variant X1, mRNA","P50115",185,{"v":7e-60,"d":"7.00E-60"},"Protein S100-A8",".",".",".",".","pfam01023","S_100","S-100/ICaBP type calcium binding domain. The S-100 domain is a subfamily of the EF-hand calcium binding proteins.","GO:0002523|leukocyte migration involved in inflammatory response;GO:0002526|acute inflammatory response;GO:0002544|chronic inflammatory response;GO:0002793|positive regulation of peptide secretion;GO:0006914|autophagy;GO:0006915|apoptotic process;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006954|inflammatory response;GO:0010043|response to zinc ion;GO:0014002|astrocyte development;GO:0018119|peptidyl-cysteine S-nitrosylation;GO:0030593|neutrophil chemotaxis;GO:0032496|response to lipopolysaccharide;GO:0035425|autocrine signaling;GO:0042060|wound healing;GO:0045087|innate immune response;GO:0045471|response to ethanol;GO:0050729|positive regulation of inflammatory response;GO:0070488|neutrophil aggregation;GO:0098869|cellular oxidant detoxification;GO:2001244|positive regulation of intrinsic apoptotic signaling pathway;","GO:0005615|extracellular space;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0045111|intermediate filament cytoskeleton;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;GO:0008017|microtubule binding;GO:0008270|zinc ion binding;GO:0016209|antioxidant activity;GO:0035662|Toll-like receptor 4 binding;GO:0048306|calcium-dependent protein binding;GO:0050544|arachidonic acid binding;GO:0050786|RAGE receptor binding;","K21127","S100A8; protein S100-A8"]
["ENSRNOG00000019728",246,20.69727609,72,4.631791549,4.468524947,2.159798679,{"v":1.36e-34,"d":"1.36E-34"},{"v":6.57e-34,"d":"6.57E-34"},"up","yes","Itgam","protein_coding","chr1:182659000-182709503:+","gi|149067646|gb|EDM17198.1|",6066,0,"integrin alpha M [Rattus norvegicus]","gi|672038371|ref|XM_006230214.2|",4009,0,"PREDICTED: Rattus norvegicus integrin, alpha M (Itgam), transcript variant X1, mRNA","P05555",2066,0,"Integrin alpha-M",".",".",".",".","pfam08441","Integrin_alpha2","Integrin alpha. This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.","GO:0001774|microglial cell activation;GO:0001781|neutrophil apoptotic process;GO:0002523|leukocyte migration involved in inflammatory response;GO:0006898|receptor-mediated endocytosis;GO:0006909|phagocytosis;GO:0006911|phagocytosis, engulfment;GO:0007155|cell adhesion;GO:0007159|leukocyte cell-cell adhesion;GO:0007229|integrin-mediated signaling pathway;GO:0010668|ectodermal cell differentiation;GO:0014005|microglia development;GO:0030593|neutrophil chemotaxis;GO:0030900|forebrain development;GO:0032930|positive regulation of superoxide anion generation;GO:0034113|heterotypic cell-cell adhesion;GO:0043315|positive regulation of neutrophil degranulation;GO:0045123|cellular extravasation;GO:0045963|negative regulation of dopamine metabolic process;GO:0050798|activated T cell proliferation;GO:0060376|positive regulation of mast cell differentiation;GO:0061756|leukocyte adhesion to vascular endothelial cell;GO:0090314|positive regulation of protein targeting to membrane;GO:0097190|apoptotic signaling pathway;GO:0097242|amyloid-beta clearance;GO:0098609|cell-cell adhesion;GO:0110090|positive regulation of hippocampal neuron apoptotic process;GO:0150062|complement-mediated synapse pruning;GO:0150064|vertebrate eye-specific patterning;GO:1901216|positive regulation of neuron death;GO:1903223|positive regulation of oxidative stress-induced neuron death;GO:1904151|positive regulation of microglial cell mediated cytotoxicity;GO:1905114|cell surface receptor signaling pathway involved in cell-cell signaling;GO:2000363|positive regulation of prostaglandin-E synthase activity;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0008305|integrin complex;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0034688|integrin alphaM-beta2 complex;GO:0044853|plasma membrane raft;","GO:0001846|opsonin binding;GO:0001851|complement component C3b binding;GO:0008201|heparin binding;GO:0031072|heat shock protein binding;GO:0038024|cargo receptor activity;GO:0043395|heparan sulfate proteoglycan binding;GO:0044877|protein-containing complex binding;GO:0046872|metal ion binding;","K06461","ITGAM, CD11b; integrin alpha MK06461; K06594"]
["ENSRNOG00000014294",464,39.03876465,235,15.11765297,2.582329725,1.368673223,1.79E-34,{"v":8.6e-34,"d":"8.60E-34"},"up","yes","Ptpn6","protein_coding","chr4:157526035-157550984:-","gi|149049491|gb|EDM01945.1|",3160,0,"protein tyrosine phosphatase, non-receptor type 6, isoform CRA_b [Rattus norvegicus]","gi|71681100|gb|BC099824.1|",1981,0,"Rattus norvegicus protein tyrosine phosphatase, non-receptor type 6, mRNA (cDNA clone MGC:124580 IMAGE:7932620), complete cds","P29351",1208,0,"Tyrosine-protein phosphatase non-receptor type 6","SPAC26F1.10c",151,{"v":4e-37,"d":"4.00E-37"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0002244|hematopoietic progenitor cell differentiation;GO:0002924|negative regulation of humoral immune response mediated by circulating immunoglobulin;GO:0006470|protein dephosphorylation;GO:0008284|positive regulation of cell proliferation;GO:0009611|response to wounding;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0030154|cell differentiation;GO:0030220|platelet formation;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0033277|abortive mitotic cell cycle;GO:0033630|positive regulation of cell adhesion mediated by integrin;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0035556|intracellular signal transduction;GO:0035855|megakaryocyte development;GO:0042130|negative regulation of T cell proliferation;GO:0042267|natural killer cell mediated cytotoxicity;GO:0043407|negative regulation of MAP kinase activity;GO:0043409|negative regulation of MAPK cascade;GO:0045577|regulation of B cell differentiation;GO:0050732|negative regulation of peptidyl-tyrosine phosphorylation;GO:0050853|B cell receptor signaling pathway;GO:0050860|negative regulation of T cell receptor signaling pathway;GO:0051279|regulation of release of sequestered calcium ion into cytosol;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:0070527|platelet aggregation;GO:1905867|epididymis development;GO:2000045|regulation of G1/S transition of mitotic cell cycle;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005911|cell-cell junction;GO:0032991|protein-containing complex;GO:0042105|alpha-beta T cell receptor complex;","GO:0001784|phosphotyrosine residue binding;GO:0004725|protein tyrosine phosphatase activity;GO:0005001|transmembrane receptor protein tyrosine phosphatase activity;GO:0005515|protein binding;GO:0017124|SH3 domain binding;GO:0019901|protein kinase binding;GO:0042169|SH2 domain binding;GO:0046703|natural killer cell lectin-like receptor binding;GO:0050839|cell adhesion molecule binding;GO:0140031|phosphorylation-dependent protein binding;","K05697","PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6 [EC:3.1.3.48]"]
["ENSRNOG00000016488",735,61.83942246,473,30.42829726,2.032299801,1.023113241,{"v":2.11e-34,"d":"2.11E-34"},1.01E-33,"up","yes","Pltp","protein_coding","chr3:153574825-153592647:-","gi|564344297|ref|XP_006235597.1|",2524,0,"PREDICTED: phospholipid transfer protein isoform X1 [Rattus norvegicus]","gi|270483882|ref|NM_001168543.1|",2025,0,"Rattus norvegicus phospholipid transfer protein (Pltp), mRNA","P55065",854,0,"Phospholipid transfer protein",".",".",".",".","pfam02886","LBP_BPI_CETP_C","LBP / BPI / CETP family, C-terminal domain. The N and C terminal domains of the LBP/BPI/CETP family are structurally similar.","GO:0006629|lipid metabolic process;GO:0006869|lipid transport;GO:0008150|biological_process;GO:0010189|vitamin E biosynthetic process;GO:0010875|positive regulation of cholesterol efflux;GO:0015914|phospholipid transport;GO:0015918|sterol transport;GO:0030317|flagellated sperm motility;GO:0034375|high-density lipoprotein particle remodeling;GO:0035627|ceramide transport;GO:0046836|glycolipid transport;GO:0120009|intermembrane lipid transfer;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0034364|high-density lipoprotein particle;","GO:0003674|molecular_function;GO:0008035|high-density lipoprotein particle binding;GO:0008429|phosphatidylethanolamine binding;GO:0008525|phosphatidylcholine transporter activity;GO:0008526|phosphatidylinositol transporter activity;GO:0019992|diacylglycerol binding;GO:0030169|low-density lipoprotein particle binding;GO:0031210|phosphatidylcholine binding;GO:0034189|very-low-density lipoprotein particle binding;GO:0070300|phosphatidic acid binding;GO:0097001|ceramide binding;GO:0120014|intermembrane phospholipid transfer activity;GO:0120017|intermembrane ceramide transfer activity;GO:0120019|intermembrane phosphotidylcholine transfer activity;GO:0120020|intermembrane cholesterol transfer activity;GO:1901611|phosphatidylglycerol binding;GO:1904121|phosphatidylethanolamine transporter activity;GO:1990050|phosphatidic acid transporter activity;","K08761","PLTP; phospholipid transfer protein"]
["ENSRNOG00000000853",552,46.44266829,311,20.00676628,2.321348071,1.214962861,{"v":4.17e-34,"d":"4.17E-34"},{"v":1.99e-33,"d":"1.99E-33"},"up","yes","Aif1","protein_coding","chr20:3646777-3652668:+","gi|564396944|ref|XP_006256123.1|",572,{"v":1e-65,"d":"1.00E-65"},"PREDICTED: allograft inflammatory factor 1 isoform X1 [Rattus norvegicus]","gi|1049210|gb|U33471.1|RNU33471",1495,0,"Rattus norvegicus balloon angioplasty responsive transcript (BART-1) mRNA, complete cds","P55009",170,{"v":4e-48,"d":"4.00E-48"},"Allograft inflammatory factor 1",".",".",".",".","pfam05110","AF-4","AF-4 proto-oncoprotein. This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.","GO:0001934|positive regulation of protein phosphorylation;GO:0006911|phagocytosis, engulfment;GO:0006954|inflammatory response;GO:0008284|positive regulation of cell proliferation;GO:0010629|negative regulation of gene expression;GO:0014739|positive regulation of muscle hyperplasia;GO:0016601|Rac protein signal transduction;GO:0021549|cerebellum development;GO:0030041|actin filament polymerization;GO:0030046|parallel actin filament bundle assembly;GO:0030335|positive regulation of cell migration;GO:0031668|cellular response to extracellular stimulus;GO:0032722|positive regulation of chemokine production;GO:0032755|positive regulation of interleukin-6 production;GO:0032870|cellular response to hormone stimulus;GO:0034097|response to cytokine;GO:0034599|cellular response to oxidative stress;GO:0042102|positive regulation of T cell proliferation;GO:0042116|macrophage activation;GO:0043066|negative regulation of apoptotic process;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0048662|negative regulation of smooth muscle cell proliferation;GO:0048678|response to axon injury;GO:0050921|positive regulation of chemotaxis;GO:0051017|actin filament bundle assembly;GO:0051384|response to glucocorticoid;GO:0051602|response to electrical stimulus;GO:0051764|actin crosslink formation;GO:0071315|cellular response to morphine;GO:0071346|cellular response to interferon-gamma;GO:0071447|cellular response to hydroperoxide;GO:0071672|negative regulation of smooth muscle cell chemotaxis;GO:0071673|positive regulation of smooth muscle cell chemotaxis;GO:0071677|positive regulation of mononuclear cell migration;GO:0090026|positive regulation of monocyte chemotaxis;GO:0090271|positive regulation of fibroblast growth factor production;GO:0097178|ruffle assembly;GO:1900087|positive regulation of G1/S transition of mitotic cell cycle;GO:2000406|positive regulation of T cell migration;","GO:0001726|ruffle;GO:0001891|phagocytic cup;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005884|actin filament;GO:0030027|lamellipodium;GO:0032587|ruffle membrane;GO:0042995|cell projection;GO:0043204|perikaryon;GO:0048471|perinuclear region of cytoplasm;","GO:0005509|calcium ion binding;GO:0051015|actin filament binding;","K18617","AIF1; allograft inflammatory factor 1"]
["ENSRNOG00000000196",612,51.49078441,365,23.48060994,2.192906596,1.132844364,{"v":7.74e-34,"d":"7.74E-34"},{"v":3.67e-33,"d":"3.67E-33"},"up","yes","Cyp19a1","protein_coding","chr8:54553165-54580758:-","gi|281182626|ref|NP_058781.2|",2553,0,"aromatase [Rattus norvegicus]","gi|281182625|ref|NM_017085.2|",2525,0,"Rattus norvegicus cytochrome P450, family 19, subfamily a, polypeptide 1 (Cyp19a1), mRNA","P22443",963,0,"Aromatase","VNG0422G",97.1,{"v":1e-20,"d":"1.00E-20"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0001553|luteinization;GO:0002677|negative regulation of chronic inflammatory response;GO:0006703|estrogen biosynthetic process;GO:0006710|androgen catabolic process;GO:0008206|bile acid metabolic process;GO:0008207|C21-steroid hormone metabolic process;GO:0008209|androgen metabolic process;GO:0008584|male gonad development;GO:0008585|female gonad development;GO:0009410|response to xenobiotic stimulus;GO:0009635|response to herbicide;GO:0010038|response to metal ion;GO:0010164|response to cesium ion;GO:0010212|response to ionizing radiation;GO:0010760|negative regulation of macrophage chemotaxis;GO:0014070|response to organic cyclic compound;GO:0018879|biphenyl metabolic process;GO:0018894|dibenzo-p-dioxin metabolic process;GO:0018963|phthalate metabolic process;GO:0021766|hippocampus development;GO:0021854|hypothalamus development;GO:0030186|melatonin metabolic process;GO:0030325|adrenal gland development;GO:0030540|female genitalia development;GO:0030851|granulocyte differentiation;GO:0030879|mammary gland development;GO:0032355|response to estradiol;GO:0033574|response to testosterone;GO:0043278|response to morphine;GO:0043627|response to estrogen;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0045779|negative regulation of bone resorption;GO:0050803|regulation of synapse structure or activity;GO:0060065|uterus development;GO:0060348|bone development;GO:0060736|prostate gland growth;GO:0061370|testosterone biosynthetic process;GO:0071333|cellular response to glucose stimulus;GO:0071371|cellular response to gonadotropin stimulus;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0071464|cellular response to hydrostatic pressure;GO:0097720|calcineurin-mediated signaling;GO:2000866|positive regulation of estradiol secretion;","GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;GO:0008021|synaptic vesicle;GO:0016020|membrane;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0043197|dendritic spine;GO:0043679|axon terminus;GO:0045202|synapse;","GO:0005506|iron ion binding;GO:0016712|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0020037|heme binding;GO:0070330|aromatase activity;","K07434","CYP19A; aromatase [EC:1.14.14.14]"]
["ENSRNOG00000038722",148,12.45201976,18,1.157947887,10.75352345,3.426737539,{"v":8.21e-34,"d":"8.21E-34"},{"v":3.89e-33,"d":"3.89E-33"},"up","yes","Tlr1","protein_coding","chr14:43384932-43397125:+","gi|149035377|gb|EDL90081.1|",4050,0,"rCG56938 [Rattus norvegicus]","gi|451770385|ref|NM_001172120.2|",2565,0,"Rattus norvegicus toll-like receptor 1 (Tlr1), mRNA","Q9EPQ1",1340,0,"Toll-like receptor 1",".",".",".",".","pfam01582","TIR","TIR domain. The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.",".",".",".",".","."]
["ENSRNOG00000018509",150,12.6202903,19,1.222278326,10.32521811,3.368100352,{"v":8.7e-34,"d":"8.70E-34"},4.11E-33,"up","yes","Cx3cr1","protein_coding","chr8:119782595-119800014:-","gi|19424190|ref|NP_598218.1|",1527,0,"CX3C chemokine receptor 1 [Rattus norvegicus]","gi|672063562|ref|XM_008766668.1|",3337,0,"PREDICTED: Rattus norvegicus chemokine (C-X3-C motif) receptor 1 (Cx3cr1), transcript variant X1, mRNA","P35411",592,0,"CX3C chemokine receptor 1",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001774|microglial cell activation;GO:0002052|positive regulation of neuroblast proliferation;GO:0002250|adaptive immune response;GO:0002282|microglial cell activation involved in immune response;GO:0002881|negative regulation of chronic inflammatory response to non-antigenic stimulus;GO:0002931|response to ischemia;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007155|cell adhesion;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007420|brain development;GO:0007613|memory;GO:0016525|negative regulation of angiogenesis;GO:0019221|cytokine-mediated signaling pathway;GO:0019722|calcium-mediated signaling;GO:0021626|central nervous system maturation;GO:0021795|cerebral cortex cell migration;GO:0030336|negative regulation of cell migration;GO:0030595|leukocyte chemotaxis;GO:0032680|regulation of tumor necrosis factor production;GO:0032691|negative regulation of interleukin-1 beta production;GO:0035176|social behavior;GO:0035425|autocrine signaling;GO:0045428|regulation of nitric oxide biosynthetic process;GO:0045766|positive regulation of angiogenesis;GO:0048246|macrophage chemotaxis;GO:0048874|host-mediated regulation of intestinal microbiota composition;GO:0050769|positive regulation of neurogenesis;GO:0050804|modulation of chemical synaptic transmission;GO:0050901|leukocyte tethering or rolling;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051897|positive regulation of protein kinase B signaling;GO:0060074|synapse maturation;GO:0060326|cell chemotaxis;GO:0061760|antifungal innate immune response;GO:0070098|chemokine-mediated signaling pathway;GO:0071222|cellular response to lipopolysaccharide;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0090026|positive regulation of monocyte chemotaxis;GO:0098883|synapse pruning;GO:0110091|negative regulation of hippocampal neuron apoptotic process;GO:0150090|multiple spine synapse organization, single dendrite;GO:1900272|negative regulation of long-term synaptic potentiation;GO:1903721|positive regulation of I-kappaB phosphorylation;GO:1904141|positive regulation of microglial cell migration;GO:1904150|negative regulation of microglial cell mediated cytotoxicity;GO:2001234|negative regulation of apoptotic signaling pathway;GO:2001240|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0032809|neuronal cell body membrane;GO:0043005|neuron projection;GO:0048471|perinuclear region of cytoplasm;GO:0097447|dendritic tree;","GO:0004896|cytokine receptor activity;GO:0004930|G protein-coupled receptor activity;GO:0004950|chemokine receptor activity;GO:0016493|C-C chemokine receptor activity;GO:0016495|C-X3-C chemokine receptor activity;GO:0019957|C-C chemokine binding;GO:0019960|C-X3-C chemokine binding;GO:0031737|CX3C chemokine receptor binding;","K04192","CX3CR1; CX3C chemokine receptor 1"]
["ENSRNOG00000013371",280,23.55787522,98,6.304382942,3.7367456,1.901782348,{"v":1.92e-33,"d":"1.92E-33"},{"v":8.97e-33,"d":"8.97E-33"},"up","yes","ENSRNOG00000013371","protein_coding","chr3:142381374-142395308:+","gi|564343773|ref|XP_006235379.1|",2300,0,"PREDICTED: BPI fold-containing family B member 6 isoform X1 [Rattus norvegicus]","gi|564343772|ref|XM_006235317.1|",1520,0,"PREDICTED: Rattus norvegicus BPI fold containing family B, member 6 (Bpifb6), transcript variant X1, mRNA","Q8BU51",810,0,"BPI fold-containing family B member 6",".",".",".",".","pfam01273","LBP_BPI_CETP","LBP / BPI / CETP family, N-terminal domain. The N and C terminal domains of the LBP/BPI/CETP family are structurally similar.",".","GO:0005576|extracellular region;","GO:0008289|lipid binding;",".","."]
["ENSRNOG00000010841",182,15.31261889,37,2.380226213,6.43326202,2.685550449,{"v":4.67e-33,"d":"4.67E-33"},{"v":2.17e-32,"d":"2.17E-32"},"up","yes","Col8a2","protein_coding","chr5:138585999-138612850:+","gi|148698346|gb|EDL30293.1|",821,{"v":8e-95,"d":"8.00E-95"},"procollagen, type VIII, alpha 2 [Mus musculus]","gi|672019925|ref|XM_006225530.2|",4251,0,"PREDICTED: Rattus norvegicus collagen, type VIII, alpha 2 (Col8a2), transcript variant X2, mRNA","P25318",324,{"v":8e-94,"d":"8.00E-94"},"Collagen alpha-2(VIII) chain",".",".",".",".","pfam00386","C1q","C1q domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.","GO:0030198|extracellular matrix organization;GO:0048593|camera-type eye morphogenesis;GO:0050673|epithelial cell proliferation;","GO:0005615|extracellular space;GO:0031012|extracellular matrix;","GO:0005201|extracellular matrix structural constituent;","K23455","COL8A; collagen type VIII alpha"]
["ENSRNOG00000049994",574,48.2936442,337,21.67935767,2.227632614,1.15551132,{"v":8.16e-33,"d":"8.16E-33"},3.77E-32,"up","yes","Ifi44l","protein_coding","chr2:240668713-240706359:+","gi|392346098|ref|XP_227820.6|",2197,0,"PREDICTED: LOW QUALITY PROTEIN: interferon-induced protein 44-like isoform X2 [Rattus norvegicus]","gi|672044524|ref|XM_227820.8|",1461,0,"PREDICTED: Rattus norvegicus interferon-induced protein 44-like (Ifi44l), transcript variant X2, mRNA","Q9BDB7",602,0,"Interferon-induced protein 44-like",".",".",".",".","pfam05316","VAR1","Mitochondrial ribosomal protein (VAR1). This family consists of the yeast mitochondrial ribosomal proteins VAR1. Mitochondria possess their own ribosomes responsible for the synthesis of a small number of proteins encoded by the mitochondrial genome. In yeast the two ribosomal RNAs and a single ribosomal protein, VAR1, are products of mitochondrial genes, and the remaining approximately 80 ribosomal proteins are encoded in the nucleus. VAR1 along with 15S rRNA are necessary for the formation of mature 37S subunits.","GO:0006955|immune response;GO:0051607|defense response to virus;","GO:0005737|cytoplasm;","GO:0005525|GTP binding;",".","."]
["ENSRNOG00000014333",620,52.16386656,378,24.31690563,2.14516877,1.101091156,{"v":8.47e-33,"d":"8.47E-33"},3.91E-32,"up","yes","Vcam1","protein_coding","chr2:204038114-204057958:-","gi|6981700|ref|NP_037021.1|",3705,0,"vascular cell adhesion protein 1 precursor [Rattus norvegicus]","gi|58476811|gb|BC089812.1|",2890,0,"Rattus norvegicus vascular cell adhesion molecule 1, mRNA (cDNA clone MGC:108734 IMAGE:7364929), complete cds","P29534",1431,0,"Vascular cell adhesion protein 1",".",".",".",".","pfam05790","C2-set","Immunoglobulin C2-set domain.","GO:0001666|response to hypoxia;GO:0002526|acute inflammatory response;GO:0002544|chronic inflammatory response;GO:0007155|cell adhesion;GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007159|leukocyte cell-cell adhesion;GO:0007160|cell-matrix adhesion;GO:0007507|heart development;GO:0007568|aging;GO:0007584|response to nutrient;GO:0009308|amine metabolic process;GO:0010043|response to zinc ion;GO:0010212|response to ionizing radiation;GO:0022614|membrane to membrane docking;GO:0032496|response to lipopolysaccharide;GO:0034113|heterotypic cell-cell adhesion;GO:0035094|response to nicotine;GO:0035584|calcium-mediated signaling using intracellular calcium source;GO:0035924|cellular response to vascular endothelial growth factor stimulus;GO:0042102|positive regulation of T cell proliferation;GO:0045471|response to ethanol;GO:0050901|leukocyte tethering or rolling;GO:0060326|cell chemotaxis;GO:0060384|innervation;GO:0060669|embryonic placenta morphogenesis;GO:0060710|chorio-allantoic fusion;GO:0060945|cardiac neuron differentiation;GO:0071333|cellular response to glucose stimulus;GO:0071356|cellular response to tumor necrosis factor;GO:0098609|cell-cell adhesion;GO:0140039|cell-cell adhesion in response to extracellular stimulus;GO:1904646|cellular response to amyloid-beta;","GO:0002102|podosome;GO:0005615|extracellular space;GO:0005769|early endosome;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005887|integral component of plasma membrane;GO:0005902|microvillus;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0030175|filopodium;GO:0042383|sarcolemma;GO:0045177|apical part of cell;GO:0071065|alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex;GO:0071944|cell periphery;","GO:0005178|integrin binding;GO:0008131|primary amine oxidase activity;GO:0050839|cell adhesion molecule binding;","K06527","VCAM1, CD106; vascular cell adhesion molecule 1"]
["ENSRNOG00000011406",122,10.26450277,8,0.514643505,19.94487964,4.317946512,{"v":1.46e-32,"d":"1.46E-32"},{"v":6.68e-32,"d":"6.68E-32"},"up","yes","Ccl4","protein_coding","chr10:68452052-68468231:+","gi|564373396|ref|XP_006247028.1|",416,{"v":4e-46,"d":"4.00E-46"},"PREDICTED: C-C motif chemokine 4 isoform X1 [Rattus norvegicus]","gi|672068332|ref|XM_006246966.2|",693,0,"PREDICTED: Rattus norvegicus chemokine (C-C motif) ligand 4 (Ccl4), transcript variant X1, mRNA","P50230",160,{"v":5e-46,"d":"5.00E-46"},"C-C motif chemokine 4",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0002548|monocyte chemotaxis;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007165|signal transduction;GO:0007186|G protein-coupled receptor signaling pathway;GO:0009636|response to toxic substance;GO:0030593|neutrophil chemotaxis;GO:0030595|leukocyte chemotaxis;GO:0032760|positive regulation of tumor necrosis factor production;GO:0043117|positive regulation of vascular permeability;GO:0043547|positive regulation of GTPase activity;GO:0043922|negative regulation by host of viral transcription;GO:0048245|eosinophil chemotaxis;GO:0048247|lymphocyte chemotaxis;GO:0050850|positive regulation of calcium-mediated signaling;GO:0051928|positive regulation of calcium ion transport;GO:0060326|cell chemotaxis;GO:0070098|chemokine-mediated signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071466|cellular response to xenobiotic stimulus;GO:2000503|positive regulation of natural killer cell chemotaxis;","GO:0005615|extracellular space;","GO:0008009|chemokine activity;GO:0031726|CCR1 chemokine receptor binding;GO:0031730|CCR5 chemokine receptor binding;GO:0042802|identical protein binding;GO:0048020|CCR chemokine receptor binding;","K12964","CCL4; C-C motif chemokine 4"]
["ENSRNOG00000010646",258,21.70689931,86,5.532417684,3.92358288,1.972171675,{"v":2.14e-32,"d":"2.14E-32"},{"v":9.74e-32,"d":"9.74E-32"},"up","yes","Tmem229b","protein_coding","chr6:97775332-97819489:-","gi|564356481|ref|XP_006240337.1|",940,{"v":2E-113,"d":"2.00E-113"},"PREDICTED: transmembrane protein 229B isoform X2 [Rattus norvegicus]","gi|157819610|ref|NM_001109359.1|",3515,0,"Rattus norvegicus transmembrane protein 229B (Tmem229b), mRNA","Q8BFQ2",346,{"v":2e-108,"d":"2.00E-108"},"Transmembrane protein 229B",".",".",".",".","pfam06541","DUF1113","Protein of unknown function (DUF1113). This family consists of several bacterial proteins of unknown function.","GO:0009617|response to bacterium;","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000021724",147,12.36788449,20,1.286608764,9.612778057,3.264953425,{"v":2.53e-32,"d":"2.53E-32"},{"v":1.15e-31,"d":"1.15E-31"},"up","yes","Ptprcap","protein_coding","chr1:201449113-201451288:+","gi|66730347|ref|NP_001019460.1|",705,{"v":8E-90,"d":"8.00E-90"},"protein tyrosine phosphatase receptor type C-associated protein precursor [Rattus norvegicus]","gi|298910651|emb|FQ225639.1|",851,0,"Rattus norvegicus TL0AEA4YF15 mRNA sequence","Q64697",200,{"v":9e-62,"d":"9.00E-62"},"Protein tyrosine phosphatase receptor type C-associated protein",".",".",".",".","pfam15258","FAM222A","Protein family of FAM222A. This protein family, FAM222A are a domain of unknown function. This family of proteins is found in eukaryotes and are typically between 411 and 562 amino acids in length. In humans, the gene encoding this protein domain lies in the position, chromosome 12 open reading frame 34.",".","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000046309",113,9.507285357,4,0.257321753,36.94707212,5.207388137,{"v":3.03e-32,"d":"3.03E-32"},1.37E-31,"up","yes","Gpr68","protein_coding","chr6:120135436-120166089:-","gi|157820739|ref|NP_001101519.1|",1946,0,"ovarian cancer G-protein coupled receptor 1 [Rattus norvegicus]","gi|157820738|ref|NM_001108049.1|",2960,0,"Rattus norvegicus G protein-coupled receptor 68 (Gpr68), mRNA","Q8BFQ3",707,0,"Ovarian cancer G-protein coupled receptor 1",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0032024|positive regulation of insulin secretion;GO:0035774|positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0045656|negative regulation of monocyte differentiation;GO:0071467|cellular response to pH;GO:2001206|positive regulation of osteoclast development;","GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;","K08408","GPR68, OGR1; ovarian cancer G-protein coupled receptor 1"]
["ENSRNOG00000053272",138,11.61066707,16,1.029287011,11.28030078,3.495733632,{"v":4.01e-32,"d":"4.01E-32"},{"v":1.81e-31,"d":"1.81E-31"},"up","yes","Chi3l1","protein_coding","chr13:45641802-45649787:+","gi|832626572|ref|NP_001296749.1|",2116,0,"chitinase-3-like protein 1 isoform 1 precursor [Rattus norvegicus]","gi|832626571|ref|NM_001309820.1|",1678,0,"Rattus norvegicus chitinase 3 like 1 (Chi3l1), transcript variant 1, mRNA","Q9WTV1",789,0,"Chitinase-3-like protein 1","BH0916_1",165,{"v":8e-44,"d":"8.00E-44"},"COG3325","pfam00704","Glyco_hydro_18","Glycosyl hydrolases family 18.","GO:0005975|carbohydrate metabolic process;GO:0006032|chitin catabolic process;GO:0006915|apoptotic process;GO:0006954|inflammatory response;GO:0007250|activation of NF-kappaB-inducing kinase activity;GO:0009612|response to mechanical stimulus;GO:0010800|positive regulation of peptidyl-threonine phosphorylation;GO:0030324|lung development;GO:0032757|positive regulation of interleukin-8 production;GO:0034612|response to tumor necrosis factor;GO:0045766|positive regulation of angiogenesis;GO:0051897|positive regulation of protein kinase B signaling;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070555|response to interleukin-1;GO:0070741|response to interleukin-6;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0048471|perinuclear region of cytoplasm;","GO:0003674|molecular_function;GO:0008061|chitin binding;GO:0030246|carbohydrate binding;","K17523","CHI3L1_2; chitinase-3-like protein 1/2"]
["ENSRNOG00000014125",160,13.46164298,27,1.736921831,7.750287171,2.954249767,{"v":4.3e-32,"d":"4.30E-32"},1.94E-31,"up","yes","Evi2b","protein_coding","chr10:64471505-64481560:-","gi|407228403|ref|NP_001258411.1|",1428,0,"protein EVI2B precursor [Rattus norvegicus]","gi|281371508|gb|AC123294.3|",2912,0,"Rattus norvegicus BAC CH230-333F9 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q8VD58",377,{"v":4e-118,"d":"4.00E-118"},"Protein EVI2B",".",".",".",".","pfam12051","DUF3533","Protein of unknown function (DUF3533). This family of transmembrane proteins is functionally uncharacterized. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 393 to 772 amino acids in length.","GO:0030854|positive regulation of granulocyte differentiation;GO:0045660|positive regulation of neutrophil differentiation;GO:2000035|regulation of stem cell division;","GO:0016021|integral component of membrane;",".","K16854","EVI2B, CD361; ecotropic viral integration site 2B protein"]
["ENSRNOG00000016469",374,31.46659047,173,11.12916581,2.827398839,1.499475407,{"v":5.3e-32,"d":"5.30E-32"},{"v":2.38e-31,"d":"2.38E-31"},"up","yes","Fxyd2","protein_coding","chr8:45712903-45720203:+","gi|149041525|gb|EDL95366.1|",379,{"v":1E-42,"d":"1.00E-42"},"FXYD domain-containing ion transport regulator 2, isoform CRA_c [Rattus norvegicus]","gi|56299|emb|X70062.1|",484,0,"R.norvegicus mRNA for gamma subunit of sodium potassium ATPase","Q04679",104,{"v":1E-26,"d":"1.00E-26"},"Sodium/potassium-transporting ATPase subunit gamma",".",".",".",".","pfam02038","ATP1G1_PLM_MAT8","ATP1G1/PLM/MAT8 family.","GO:0006813|potassium ion transport;GO:0006814|sodium ion transport;GO:0008285|negative regulation of cell proliferation;GO:0071475|cellular hyperosmotic salinity response;GO:0098662|inorganic cation transmembrane transport;GO:1903406|regulation of sodium:potassium-exchanging ATPase activity;GO:1903407|negative regulation of sodium:potassium-exchanging ATPase activity;GO:2000649|regulation of sodium ion transmembrane transporter activity;","GO:0005886|plasma membrane;GO:0005890|sodium:potassium-exchanging ATPase complex;GO:0016020|membrane;GO:0016323|basolateral plasma membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0005515|protein binding;GO:0017080|sodium channel regulator activity;","K01538","FXYD2, ATP1G1; sodium/potassium-transporting ATPase subunit gamma (FXYD domain-containing ion transport regulator 2)"]
["ENSRNOG00000050430",237,19.94005867,74,4.760452426,4.188689832,2.066499058,1.16E-31,{"v":5.13e-31,"d":"5.13E-31"},"up","yes","Vav1","protein_coding","chr9:2157900-2208937:+","gi|162287067|ref|NP_036891.2|",4363,0,"proto-oncogene vav [Rattus norvegicus]","gi|162287066|ref|NM_012759.2|",2822,0,"Rattus norvegicus vav guanine nucleotide exchange factor 1 (Vav1), mRNA","P54100",1679,0,"Proto-oncogene vav",".",".",".",".","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0002768|immune response-regulating cell surface receptor signaling pathway;GO:0006909|phagocytosis;GO:0006955|immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007229|integrin-mediated signaling pathway;GO:0007264|small GTPase mediated signal transduction;GO:0008361|regulation of cell size;GO:0030217|T cell differentiation;GO:0030593|neutrophil chemotaxis;GO:0035556|intracellular signal transduction;GO:0042110|T cell activation;GO:0043087|regulation of GTPase activity;GO:0043547|positive regulation of GTPase activity;GO:0045785|positive regulation of cell adhesion;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;GO:0048468|cell development;GO:0072593|reactive oxygen species metabolic process;","GO:0005911|cell-cell junction;","GO:0001784|phosphotyrosine residue binding;GO:0005085|guanyl-nucleotide exchange factor activity;GO:0046872|metal ion binding;GO:0140031|phosphorylation-dependent protein binding;","K05730","VAV; guanine nucleotide exchange factor VAV"]
["ENSRNOG00000002278",488,41.0580111,269,17.30488787,2.372625087,1.24648415,1.59E-31,{"v":6.99e-31,"d":"6.99E-31"},"up","yes","Tec","protein_coding","chr14:35352829-35461557:+","gi|197304782|ref|NP_445884.1|",3025,0,"tyrosine-protein kinase Tec [Rattus norvegicus]","gi|197304781|ref|NM_053432.1|",1975,0,"Rattus norvegicus tec protein tyrosine kinase (Tec), mRNA","P24604",1143,0,"Tyrosine-protein kinase Tec",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0002250|adaptive immune response;GO:0007229|integrin-mediated signaling pathway;GO:0010543|regulation of platelet activation;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0035556|intracellular signal transduction;GO:0038083|peptidyl-tyrosine autophosphorylation;GO:0042246|tissue regeneration;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050852|T cell receptor signaling pathway;GO:0050853|B cell receptor signaling pathway;","GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;","GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0005524|ATP binding;GO:0046872|metal ion binding;","K07364","TEC; tyrosine-protein kinase Tec [EC:2.7.10.2]"]
["ENSRNOG00000064184",118,9.9279617,8,0.514643505,19.29094916,4.269852224,{"v":2.23e-31,"d":"2.23E-31"},{"v":9.82e-31,"d":"9.82E-31"},"up","yes","Phf11b","protein_coding","chr15:33363395-33378606:-","gi|62079205|ref|NP_001014257.1|",1344,0,"PHD finger protein 11-like [Rattus norvegicus]","gi|62079204|ref|NM_001014235.1|",1155,0,"Rattus norvegicus PHD finger protein 11B (Phf11b), mRNA","Q5I0J8",522,0,"PHD finger protein 11-like",".",".",".",".","pfam13771","zf-HC5HC2H","PHD-like zinc-binding domain. The members of this family are annotated as containing PHD domain, but the zinc-binding region here is not typical of PHD domains. The conformation here is a well-conserved cysteine-histidine rich region spanning 90 residues, where the Cys and His are arranged as HxxC(31)CxxC(6)CxxCxxxxCxxxxHxxC (21)CxxH.",".",".",".",".","."]
["ENSRNOG00000055197",129,10.85344966,13,0.836295696,12.97800491,3.697996712,{"v":2.27e-31,"d":"2.27E-31"},{"v":9.98e-31,"d":"9.98E-31"},"up","yes","AABR07027872.1","protein_coding","chr17:45680483-45686011:-","gi|2118701|pir||JC4683",802,{"v":7E-105,"d":"7.00E-105"},"T-cell receptor gamma chain C region - rat","gi|1359459|dbj|D55648.1|RATTCRGC",628,0,"Rattus sp. mRNA for T-cell receptor gamma chain, complete cds","P06334",214,{"v":6E-68,"d":"6.00E-68"},"T-cell receptor gamma chain C region DFL12",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.",".",".",".",".","."]
["ENSRNOG00000009227",574,48.2936442,345,22.19400117,2.175977365,1.12166355,{"v":2.3e-31,"d":"2.30E-31"},1.01E-30,"up","yes","Aplnr","protein_coding","chr3:70217385-70221050:+","gi|13786192|ref|NP_112639.1|",1693,0,"apelin receptor [Rattus norvegicus]","gi|48675846|ref|NM_031349.2|",3644,0,"Rattus norvegicus apelin receptor (Aplnr), mRNA","Q9JHG3",656,0,"Apelin receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001525|angiogenesis;GO:0001568|blood vessel development;GO:0001570|vasculogenesis;GO:0001944|vasculature development;GO:0001947|heart looping;GO:0003171|atrioventricular valve development;GO:0003272|endocardial cushion formation;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007369|gastrulation;GO:0007507|heart development;GO:0007512|adult heart development;GO:0010468|regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0031065|positive regulation of histone deacetylation;GO:0035886|vascular smooth muscle cell differentiation;GO:0035904|aorta development;GO:0043951|negative regulation of cAMP-mediated signaling;GO:0045766|positive regulation of angiogenesis;GO:0050878|regulation of body fluid levels;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;GO:0060183|apelin receptor signaling pathway;GO:0060412|ventricular septum morphogenesis;GO:0060841|venous blood vessel development;GO:0060976|coronary vasculature development;GO:1903589|positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:1903596|regulation of gap junction assembly;GO:1904325|positive regulation of inhibitory G protein-coupled receptor phosphorylation;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0042277|peptide binding;GO:0060182|apelin receptor activity;","K04174","APLNR; apelin receptor"]
["ENSRNOG00000052880",155,13.04096664,26,1.672591393,7.796863416,2.962893862,{"v":3.16e-31,"d":"3.16E-31"},{"v":1.38e-30,"d":"1.38E-30"},"up","yes","Prph","protein_coding","chr7:130218357-130222136:+","gi|672059812|ref|XP_008763891.1|",1847,0,"PREDICTED: peripherin isoform X2 [Rattus norvegicus]","gi|672059811|ref|XM_008765669.1|",1849,0,"PREDICTED: Rattus norvegicus peripherin (Prph), transcript variant X2, mRNA","P21807",656,0,"Peripherin",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0045104|intermediate filament cytoskeleton organization;","GO:0001750|photoreceptor outer segment;GO:0005882|intermediate filament;GO:0005883|neurofilament;GO:0030424|axon;GO:0042622|photoreceptor outer segment membrane;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0043204|perikaryon;GO:0044299|C-fiber;GO:0045098|type III intermediate filament;","GO:0005198|structural molecule activity;GO:0005515|protein binding;GO:0044877|protein-containing complex binding;","K07607","PRPH; peripherin"]
["ENSRNOG00000029662",226,19.01457071,68,4.374469797,4.346714367,2.119925296,{"v":3.23e-31,"d":"3.23E-31"},1.41E-30,"up","yes","Wdfy4","protein_coding","chr16:8221719-8450491:-","gi|564388240|ref|XP_006252821.1|",16294,0,"PREDICTED: WD repeat- and FYVE domain-containing protein 4 isoform X4 [Rattus norvegicus]","gi|672079821|ref|XM_006252759.2|",10075,0,"PREDICTED: Rattus norvegicus WDFY family member 4 (Wdfy4), transcript variant X4, mRNA","Q6ZS81",4984,0,"WD repeat- and FYVE domain-containing protein 4",".",".",".",".","pfam02138","Beach","Beige/BEACH domain.","GO:0019882|antigen processing and presentation;GO:0036037|CD8-positive, alpha-beta T cell activation;GO:0098586|cellular response to virus;",".",".","K24777","WDFY4; WD repeat and FYVE domain-containing protein 4"]
["ENSRNOG00000066159",162,13.62991352,30,1.929913146,7.062449184,2.820168582,{"v":4.47e-31,"d":"4.47E-31"},{"v":1.95e-30,"d":"1.95E-30"},"up","yes","Cpm","protein_coding","chr7:53225696-53286220:+","gi|157821719|ref|NP_001101568.1|",2395,0,"carboxypeptidase M precursor [Rattus norvegicus]","gi|157821718|ref|NM_001108098.1|",5442,0,"Rattus norvegicus carboxypeptidase M (Cpm), mRNA","Q80V42",881,0,"Carboxypeptidase M","sll0236",70.5,{"v":3E-11,"d":"3.00E-11"},"COG2866","pfam00246","Peptidase_M14","Zinc carboxypeptidase.",".",".",".",".","."]
["ENSRNOG00000038228",258,21.70689931,90,5.789739437,3.749201419,1.906583334,{"v":4.78e-31,"d":"4.78E-31"},2.08E-30,"up","yes","Serp2","protein_coding","chr15:51879877-51904785:-","gi|568988885|ref|XP_006519662.1|",517,{"v":2e-59,"d":"2.00E-59"},"PREDICTED: stress-associated endoplasmic reticulum protein 2 isoform X1 [Mus musculus]","gi|157819352|ref|NM_001109104.1|",739,0,"Rattus norvegicus stress-associated endoplasmic reticulum protein family member 2 (Serp2), mRNA","Q6TAW2",111,{"v":4e-28,"d":"4.00E-28"},"Stress-associated endoplasmic reticulum protein 2",".",".",".",".","pfam06624","RAMP4","Ribosome associated membrane protein RAMP4. This family consists of several ribosome associated membrane protein RAMP4 (or SERP1) sequences. Stabilisation of membrane proteins in response to stress involves the concerted action of a rescue unit in the ER membrane comprised of SERP1/RAMP4, other components of the translocon, and molecular chaperones in the ER.","GO:0006486|protein glycosylation;GO:0015031|protein transport;GO:0030968|endoplasmic reticulum unfolded protein response;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000009347",313,26.33433909,130,8.362956964,3.148926773,1.654860209,{"v":5.73e-31,"d":"5.73E-31"},{"v":2.49e-30,"d":"2.49E-30"},"up","yes","Arhgap25","protein_coding","chr4:119896844-119974982:-","gi|157823601|ref|NP_001102717.1|",3289,0,"rho GTPase-activating protein 25 [Rattus norvegicus]","gi|157823600|ref|NM_001109247.1|",2982,0,"Rattus norvegicus Rho GTPase activating protein 25 (Arhgap25), mRNA","Q8BYW1",1216,0,"Rho GTPase-activating protein 25",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0006911|phagocytosis, engulfment;GO:0007015|actin filament organization;GO:0007165|signal transduction;GO:0051058|negative regulation of small GTPase mediated signal transduction;GO:0090630|activation of GTPase activity;","GO:0001891|phagocytic cup;","GO:0005096|GTPase activator activity;","K20642","ARHGAP22_24_25; Rho GTPase-activating protein 22/24/25"]
["ENSRNOG00000028548",107,9.002473745,3,0.192991315,46.64704091,5.54371366,{"v":7.15e-31,"d":"7.15E-31"},{"v":3.1e-30,"d":"3.10E-30"},"up","yes","Ccl9","protein_coding","chr10:68366487-68371369:-","gi|59891435|ref|NP_001012357.1|",623,{"v":1e-76,"d":"1.00E-76"},"C-C motif chemokine 9 precursor [Rattus norvegicus]","gi|59891434|ref|NM_001012357.1|",1288,0,"Rattus norvegicus chemokine (C-C motif) ligand 9 (Ccl9), mRNA","P51670",182,{"v":4e-54,"d":"4.00E-54"},"C-C motif chemokine 9",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0002548|monocyte chemotaxis;GO:0006954|inflammatory response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0030593|neutrophil chemotaxis;GO:0043547|positive regulation of GTPase activity;GO:0048247|lymphocyte chemotaxis;GO:0070098|chemokine-mediated signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;","GO:0005615|extracellular space;","GO:0008009|chemokine activity;GO:0048020|CCR chemokine receptor binding;","K22671","CCL9; C-C motif chemokine 9"]
["ENSRNOG00000018971",595,50.06048484,367,23.60927081,2.120374036,1.08431878,{"v":8.26e-31,"d":"8.26E-31"},{"v":3.57e-30,"d":"3.57E-30"},"up","yes","Mob3a","protein_coding","chr7:9010587-9027879:+","gi|157823747|ref|NP_001102204.1|",1181,{"v":2e-154,"d":"2.00E-154"},"MOB kinase activator 3A [Rattus norvegicus]","gi|197927363|ref|NM_001108734.2|",1720,0,"Rattus norvegicus MOB kinase activator 3A (Mob3a), mRNA","Q8BSU7",454,{"v":3e-154,"d":"3.00E-154"},"MOB kinase activator 3A",".",".",".",".","pfam03637","Mob1_phocein","Mob1/phocein family. Mob1 is an essential Saccharomyces cerevisiae protein, identified from a two-hybrid screen, that binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Mob1 contains no known structural motifs; however MOB1 is a member of a conserved gene family and shares sequence similarity with a nonessential yeast gene, MOB2. Mob1 is a phosphoprotein in vivo and a substrate for the Mps1p kinase in vitro. Conditional alleles of MOB1 cause a late nuclear division arrest at restrictive temperature. This family also includes phocein, a rat protein that by yeast two hybrid interacts with striatin.","GO:0001934|positive regulation of protein phosphorylation;GO:0007165|signal transduction;GO:0016310|phosphorylation;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0016301|kinase activity;GO:0030295|protein kinase activator activity;",".","."]
["ENSRNOG00000050848",475,39.96425261,262,16.8545748,2.37112197,1.245569876,{"v":1.07e-30,"d":"1.07E-30"},{"v":4.58e-30,"d":"4.58E-30"},"up","yes","Dtx1","protein_coding","chr12:35849617-35880838:+","gi|60360548|dbj|BAD90518.1|",2979,0,"mKIAA4160 protein [Mus musculus]","gi|672073190|ref|XM_006249412.2|",3596,0,"PREDICTED: Rattus norvegicus deltex 1, E3 ubiquitin ligase (Dtx1), transcript variant X1, mRNA","Q61010",1058,0,"E3 ubiquitin-protein ligase DTX1",".",".",".",".","pfam02825","WWE","WWE domain. The WWE domain is named after three of its conserved residues and is predicted to mediate specific protein- protein interactions in ubiquitin and ADP ribose conjugation systems.","GO:0007219|Notch signaling pathway;GO:0008593|regulation of Notch signaling pathway;GO:0010001|glial cell differentiation;GO:0016567|protein ubiquitination;GO:0045581|negative regulation of T cell differentiation;GO:0045665|negative regulation of neuron differentiation;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0016604|nuclear body;","GO:0005112|Notch binding;GO:0008270|zinc ion binding;GO:0031625|ubiquitin protein ligase binding;GO:0061630|ubiquitin protein ligase activity;","K06058","DTX; deltex [EC:2.3.2.27]"]
["ENSRNOG00000006940",254,21.37035824,89,5.725408998,3.73254701,1.900160431,{"v":1.84e-30,"d":"1.84E-30"},{"v":7.84e-30,"d":"7.84E-30"},"up","yes","Ncf4","protein_coding","chr7:109826020-109843389:+","gi|187937026|ref|NP_001120776.1|",1771,0,"neutrophil cytosol factor 4 [Rattus norvegicus]","gi|187937025|ref|NM_001127304.1|",1496,0,"Rattus norvegicus neutrophil cytosolic factor 4 (Ncf4), mRNA","P97369",671,0,"Neutrophil cytosol factor 4",".",".",".",".","pfam00787","PX","PX domain. PX domains bind to phosphoinositides.","GO:0006909|phagocytosis;GO:0042554|superoxide anion generation;GO:0045730|respiratory burst;GO:0050790|regulation of catalytic activity;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0010008|endosome membrane;GO:0016020|membrane;GO:0043020|NADPH oxidase complex;","GO:0016176|superoxide-generating NADPH oxidase activator activity;GO:0032266|phosphatidylinositol-3-phosphate binding;","K08012","NCF4, P40PHOX; neutrophil cytosolic factor 4"]
["ENSRNOG00000058094",495,41.64695798,281,18.07685313,2.303883186,1.204067569,{"v":2.4e-30,"d":"2.40E-30"},{"v":1.02e-29,"d":"1.02E-29"},"up","yes","AABR07028902.1","protein_coding","chr17:86241384-86443480:+","gi|16758280|ref|NP_445970.1|",19333,0,"lysosomal-trafficking regulator [Rattus norvegicus]","gi|568981579|ref|XM_006516561.1|",9844,0,"PREDICTED: Mus musculus lysosomal trafficking regulator (Lyst), transcript variant X1, mRNA","P97412",7039,0,"Lysosomal-trafficking regulator",".",".",".",".","pfam02138","Beach","Beige/BEACH domain.",".",".",".",".","."]
["ENSRNOG00000011750",256,21.53862877,91,5.854069875,3.679257206,1.879414535,{"v":2.91e-30,"d":"2.91E-30"},1.23E-29,"up","yes","Fam180a","protein_coding","chr4:63992867-64008047:-","gi|157820567|ref|NP_001102091.1|",710,{"v":1E-87,"d":"1.00E-87"},"protein FAM180A precursor [Rattus norvegicus]","gi|157820566|ref|NM_001108621.1|",1573,0,"Rattus norvegicus family with sequence similarity 180, member A (Fam180a), mRNA","Q8BR21",254,{"v":6e-80,"d":"6.00E-80"},"Protein FAM180A",".",".",".",".","pfam15173","FAM180","FAM180 family. This family of proteins is found in eukaryotes. Proteins in this family are typically between 117 and 182 amino acids in length. There are two conserved sequence motifs: ELAS and DFE. The function of this family is unknown.",".",".",".",".","."]
["ENSRNOG00000054561",217,18.2573533,65,4.181478482,4.366243513,2.126392594,{"v":3.77e-30,"d":"3.77E-30"},{"v":1.59e-29,"d":"1.59E-29"},"up","yes","Isg20","protein_coding","chr1:132815123-132837027:+","gi|157817035|ref|NP_001101957.1|",1202,{"v":6E-158,"d":"6.00E-158"},"apoptosis-enhancing nuclease [Rattus norvegicus]","gi|186910199|ref|NM_001108487.2|",1068,0,"Rattus norvegicus apoptosis enhancing nuclease (Aen), mRNA","B2GUW6",467,{"v":2E-159,"d":"2.00E-159"},"Apoptosis-enhancing nuclease","YOL080c",123,{"v":2e-30,"d":"2.00E-30"},"COG0847","pfam00929","RNase_T","Exonuclease. This family includes a variety of exonuclease proteins, such as ribonuclease T and the epsilon subunit of DNA polymerase III.;","GO:0000738|DNA catabolic process, exonucleolytic;GO:0006401|RNA catabolic process;GO:0009615|response to virus;GO:0045071|negative regulation of viral genome replication;GO:0051607|defense response to virus;GO:0090503|RNA phosphodiester bond hydrolysis, exonucleolytic;","GO:0005634|nucleus;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0015030|Cajal body;GO:0016605|PML body;","GO:0000175|3'-5'-exoribonuclease activity;GO:0004527|exonuclease activity;GO:0008310|single-stranded DNA 3'-5' exodeoxyribonuclease activity;GO:0030619|U1 snRNA binding;GO:0030620|U2 snRNA binding;GO:0034511|U3 snoRNA binding;","K12579","ISG20; interferon-stimulated gene 20 kDa protein [EC:3.1.13.1]"]
["ENSRNOG00000008215",404,33.99064853,205,13.18773983,2.577443063,1.365940558,3.79E-30,{"v":1.6e-29,"d":"1.60E-29"},"up","yes","Trim47","protein_coding","chr10:101337573-101342044:-","gi|157818923|ref|NP_001103055.1|",2610,0,"tripartite motif-containing protein 47 [Rattus norvegicus]","gi|157818922|ref|NM_001109585.1|",2198,0,"Rattus norvegicus tripartite motif-containing 47 (Trim47), mRNA","Q8C0E3",979,0,"Tripartite motif-containing protein 47",".",".",".",".","pfam15227","zf-C3HC4_4","zinc finger of C3HC4-type, RING. This is a family of primate-specific Ret finger protein-like (RFPL) zinc-fingers of the C3HC4 type. Ret finger protein-like proteins are primate-specific target genes of Pax6, a key transcription factor for pancreas, eye and neocortex development. This domain is likely to be DNA-binding. This zinc-finger domain together with the RDM domain, pfam11002, forms a large zinc-finger structure of the RING/U-Box superfamily. RING-containing proteins are known to exert an E3 ubiquitin protein ligase activity with the zinc-finger structure being mandatory for binding to the E2 ubiquitin-conjugating enzyme.","GO:0016567|protein ubiquitination;","GO:0005829|cytosol;","GO:0004842|ubiquitin-protein transferase activity;GO:0008270|zinc ion binding;","K12023","TRIM47; tripartite motif-containing protein 47"]
["ENSRNOG00000042309",564,47.45229152,344,22.12967074,2.144283667,1.100495772,{"v":5.8e-30,"d":"5.80E-30"},{"v":2.44e-29,"d":"2.44E-29"},"up","yes","Kiaa0408L","protein_coding","chr1:28615606-28630309:-","gi|242117994|ref|NP_001138331.2|",3217,0,"uncharacterized protein KIAA0408 homolog [Rattus norvegicus]","gi|242117993|ref|NM_001144859.2|",4152,0,"Rattus norvegicus SOGA family member 3 (Soga3), mRNA",".",".",".",".",".",".",".",".","pfam14818","DUF4482","Domain of unknown function (DUF4482). This family is found in eukaryotes, and is approximately 140 amino acids in length. The family is found in association with pfam11365.",".",".",".",".","."]
["ENSRNOG00000024277",163,13.71404879,33,2.12290446,6.4600405,2.69154321,{"v":7.55e-30,"d":"7.55E-30"},3.17E-29,"up","yes","Card11","protein_coding","chr12:13621087-13758112:+","gi|47847424|dbj|BAD21384.1|",5639,0,"mFLJ00120 protein [Mus musculus]","gi|672026525|ref|XM_008758980.1|",3888,0,"PREDICTED: Rattus norvegicus caspase recruitment domain family, member 11 (LOC100363332), transcript variant X1, mRNA","Q8CIS0",2140,0,"Caspase recruitment domain-containing protein 11",".",".",".",".","pfam00619","CARD","Caspase recruitment domain. Motif contained in proteins involved in apoptotic signaling. Predicted to possess a DEATH (pfam00531) domain-like fold.","GO:0007165|signal transduction;GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0008150|biological_process;GO:0030183|B cell differentiation;GO:0030890|positive regulation of B cell proliferation;GO:0031295|T cell costimulation;GO:0032743|positive regulation of interleukin-2 production;GO:0038202|TORC1 signaling;GO:0042100|B cell proliferation;GO:0042102|positive regulation of T cell proliferation;GO:0042110|T cell activation;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045061|thymic T cell selection;GO:0045577|regulation of B cell differentiation;GO:0045580|regulation of T cell differentiation;GO:0046649|lymphocyte activation;GO:0048872|homeostasis of number of cells;GO:0050776|regulation of immune response;GO:0050862|positive regulation of T cell receptor signaling pathway;GO:0050870|positive regulation of T cell activation;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051260|protein homooligomerization;","GO:0001772|immunological synapse;GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0032449|CBM complex;GO:0045121|membrane raft;","GO:0003674|molecular_function;GO:0043621|protein self-association;GO:0050700|CARD domain binding;","K07367","CARD11; caspase recruitment domain-containing protein 11"]
["ENSRNOG00000010906",251,21.11795243,89,5.725408998,3.688461809,1.883019298,{"v":8.9e-30,"d":"8.90E-30"},3.73E-29,"up","yes","Ccl5","protein_coding","chr10:68322829-68327377:-","gi|61889094|ref|NP_112378.2|",337,{"v":3e-35,"d":"3.00E-35"},"C-C motif chemokine 5 precursor [Rattus norvegicus]","gi|354800115|gb|JN964616.1|",465,0,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Ccl5:tm1a(EUCOMM)Hmgu; transgenic","P50231",130,{"v":2E-35,"d":"2.00E-35"},"C-C motif chemokine 5",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0000165|MAPK cascade;GO:0002544|chronic inflammatory response;GO:0002548|monocyte chemotaxis;GO:0006468|protein phosphorylation;GO:0006816|calcium ion transport;GO:0006874|cellular calcium ion homeostasis;GO:0006887|exocytosis;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007159|leukocyte cell-cell adhesion;GO:0007165|signal transduction;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007267|cell-cell signaling;GO:0007568|aging;GO:0009410|response to xenobiotic stimulus;GO:0009615|response to virus;GO:0009617|response to bacterium;GO:0009636|response to toxic substance;GO:0009651|response to salt stress;GO:0010628|positive regulation of gene expression;GO:0010759|positive regulation of macrophage chemotaxis;GO:0010820|positive regulation of T cell chemotaxis;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0014070|response to organic cyclic compound;GO:0014823|response to activity;GO:0014911|positive regulation of smooth muscle cell migration;GO:0018894|dibenzo-p-dioxin metabolic process;GO:0030335|positive regulation of cell migration;GO:0030593|neutrophil chemotaxis;GO:0031269|pseudopodium assembly;GO:0031328|positive regulation of cellular biosynthetic process;GO:0031584|activation of phospholipase D activity;GO:0031622|positive regulation of fever generation;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0031667|response to nutrient levels;GO:0032496|response to lipopolysaccharide;GO:0032868|response to insulin;GO:0033634|positive regulation of cell-cell adhesion mediated by integrin;GO:0034097|response to cytokine;GO:0034112|positive regulation of homotypic cell-cell adhesion;GO:0034341|response to interferon-gamma;GO:0034612|response to tumor necrosis factor;GO:0035688|T-helper 1 cell diapedesis;GO:0042102|positive regulation of T cell proliferation;GO:0042119|neutrophil activation;GO:0042327|positive regulation of phosphorylation;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0043491|protein kinase B signaling;GO:0043547|positive regulation of GTPase activity;GO:0043627|response to estrogen;GO:0043922|negative regulation by host of viral transcription;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0045071|negative regulation of viral genome replication;GO:0045666|positive regulation of neuron differentiation;GO:0045672|positive regulation of osteoclast differentiation;GO:0045744|negative regulation of G protein-coupled receptor signaling pathway;GO:0045766|positive regulation of angiogenesis;GO:0045785|positive regulation of cell adhesion;GO:0048245|eosinophil chemotaxis;GO:0048247|lymphocyte chemotaxis;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0050679|positive regulation of epithelial cell proliferation;GO:0050796|regulation of insulin secretion;GO:0050863|regulation of T cell activation;GO:0050918|positive chemotaxis;GO:0051384|response to glucocorticoid;GO:0051928|positive regulation of calcium ion transport;GO:0060326|cell chemotaxis;GO:0060548|negative regulation of cell death;GO:0060754|positive regulation of mast cell chemotaxis;GO:0061098|positive regulation of protein tyrosine kinase activity;GO:0070098|chemokine-mediated signaling pathway;GO:0070100|negative regulation of chemokine-mediated signaling pathway;GO:0070233|negative regulation of T cell apoptotic process;GO:0070234|positive regulation of T cell apoptotic process;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070723|response to cholesterol;GO:0071222|cellular response to lipopolysaccharide;GO:0071230|cellular response to amino acid stimulus;GO:0071307|cellular response to vitamin K;GO:0071315|cellular response to morphine;GO:0071345|cellular response to cytokine stimulus;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071361|cellular response to ethanol;GO:0071396|cellular response to lipid;GO:0071403|cellular response to high density lipoprotein particle stimulus;GO:0071407|cellular response to organic cyclic compound;GO:0071448|cellular response to alkyl hydroperoxide;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0090026|positive regulation of monocyte chemotaxis;GO:0097305|response to alcohol;GO:0098586|cellular response to virus;GO:1901214|regulation of neuron death;GO:1901215|negative regulation of neuron death;GO:2000110|negative regulation of macrophage apoptotic process;GO:2000406|positive regulation of T cell migration;GO:2000503|positive regulation of natural killer cell chemotaxis;","GO:0005615|extracellular space;GO:0005737|cytoplasm;","GO:0004435|phosphatidylinositol phospholipase C activity;GO:0004672|protein kinase activity;GO:0008009|chemokine activity;GO:0008201|heparin binding;GO:0016004|phospholipase activator activity;GO:0030298|receptor signaling protein tyrosine kinase activator activity;GO:0031726|CCR1 chemokine receptor binding;GO:0031730|CCR5 chemokine receptor binding;GO:0042056|chemoattractant activity;GO:0042379|chemokine receptor binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0043621|protein self-association;GO:0046817|chemokine receptor antagonist activity;GO:0048020|CCR chemokine receptor binding;","K12499","CCL5; C-C motif chemokine 5"]
["ENSRNOG00000008062",382,32.13967262,189,12.15845282,2.643401517,1.402395579,{"v":1.07e-29,"d":"1.07E-29"},{"v":4.46e-29,"d":"4.46E-29"},"up","yes","Dqx1","protein_coding","chr4:115563752-115572590:+","gi|157821145|ref|NP_001102877.1|",3331,0,"ATP-dependent RNA helicase DQX1 [Rattus norvegicus]","gi|157821144|ref|NM_001109407.1|",2606,0,"Rattus norvegicus DEAQ box RNA-dependent ATPase 1 (Dqx1), mRNA","Q924H9",1213,0,"ATP-dependent RNA helicase DQX1","SPBC16H5.10c",342,{"v":1e-103,"d":"1.00E-103"},"COG1643","pfam07717","OB_NTP_bind","Oligonucleotide/oligosaccharide-binding (OB)-fold. This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.",".","GO:0005622|intracellular;GO:0005681|spliceosomal complex;","GO:0003723|RNA binding;GO:0004386|helicase activity;GO:0005524|ATP binding;","K14433","DQX1; ATP-dependent RNA helicase DQX1 [EC:3.6.4.13]"]
["ENSRNOG00000066100",129,10.85344966,16,1.029287011,10.54462899,3.39843643,{"v":1.69e-29,"d":"1.69E-29"},{"v":7.03e-29,"d":"7.03E-29"},"up","yes","ENSRNOG00000066100","TR_C_gene","chr17:45678485-45678628:-","gi|913547|gb|AAB32520.1|",148,{"v":3E-10,"d":"3.00E-10"},"T-cell receptor gamma chain [Rattus sp.]","gi|558686|emb|Z27087.1|",144,{"v":3E-68,"d":"3.00E-68"},"R.norvegicus (F344/Crj)rearranged mRNA for T-cell receptor gamma chain (1483bp)","P01853",48.1,{"v":1e-07,"d":"1.00E-07"},"T-cell receptor gamma chain C region C10.5",".",".",".",".","pfam02066","Metallothio_11","Metallothionein family 11.",".",".",".",".","."]
["ENSRNOG00000010475",511,42.99312228,300,19.29913146,2.227723169,1.155569965,{"v":2.12e-29,"d":"2.12E-29"},{"v":8.77e-29,"d":"8.77E-29"},"up","yes","Casp3","protein_coding","chr16:45662910-45684648:-","gi|6978605|ref|NP_037054.1|",1498,0,"caspase-3 [Rattus norvegicus]","gi|672080148|ref|XM_006253130.2|",2421,0,"PREDICTED: Rattus norvegicus caspase 3 (Casp3), transcript variant X1, mRNA","P55213",581,0,"Caspase-3",".",".",".",".","pfam00656","Peptidase_C14","Caspase domain.","GO:0001554|luteolysis;GO:0001666|response to hypoxia;GO:0001782|B cell homeostasis;GO:0006508|proteolysis;GO:0006915|apoptotic process;GO:0006974|cellular response to DNA damage stimulus;GO:0007413|axonal fasciculation;GO:0007507|heart development;GO:0007605|sensory perception of sound;GO:0007611|learning or memory;GO:0008627|intrinsic apoptotic signaling pathway in response to osmotic stress;GO:0009410|response to xenobiotic stimulus;GO:0009411|response to UV;GO:0009611|response to wounding;GO:0009749|response to glucose;GO:0010033|response to organic substance;GO:0010038|response to metal ion;GO:0010165|response to X-ray;GO:0010996|response to auditory stimulus;GO:0014070|response to organic cyclic compound;GO:0016485|protein processing;GO:0021766|hippocampus development;GO:0030182|neuron differentiation;GO:0030216|keratinocyte differentiation;GO:0030218|erythrocyte differentiation;GO:0030889|negative regulation of B cell proliferation;GO:0031647|regulation of protein stability;GO:0032025|response to cobalt ion;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0034349|glial cell apoptotic process;GO:0035094|response to nicotine;GO:0035556|intracellular signal transduction;GO:0042060|wound healing;GO:0042542|response to hydrogen peroxide;GO:0043029|T cell homeostasis;GO:0043065|positive regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0043200|response to amino acid;GO:0043525|positive regulation of neuron apoptotic process;GO:0045165|cell fate commitment;GO:0045736|negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045786|negative regulation of cell cycle;GO:0046007|negative regulation of activated T cell proliferation;GO:0046677|response to antibiotic;GO:0048011|neurotrophin TRK receptor signaling pathway;GO:0051146|striated muscle cell differentiation;GO:0051384|response to glucocorticoid;GO:0051402|neuron apoptotic process;GO:0061713|anterior neural tube closure;GO:0071310|cellular response to organic substance;GO:0071407|cellular response to organic cyclic compound;GO:0071887|leukocyte apoptotic process;GO:0072734|cellular response to staurosporine;GO:0097194|execution phase of apoptosis;GO:1902004|positive regulation of amyloid-beta formation;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0031264|death-inducing signaling complex;GO:0043025|neuronal cell body;GO:0045121|membrane raft;","GO:0002020|protease binding;GO:0004175|endopeptidase activity;GO:0004190|aspartic-type endopeptidase activity;GO:0004197|cysteine-type endopeptidase activity;GO:0004861|cyclin-dependent protein serine/threonine kinase inhibitor activity;GO:0005123|death receptor binding;GO:0005515|protein binding;GO:0008233|peptidase activity;GO:0008234|cysteine-type peptidase activity;GO:0016005|phospholipase A2 activator activity;GO:0044877|protein-containing complex binding;GO:0097153|cysteine-type endopeptidase activity involved in apoptotic process;GO:0097199|cysteine-type endopeptidase activity involved in apoptotic signaling pathway;GO:0097200|cysteine-type endopeptidase activity involved in execution phase of apoptosis;","K02187","CASP3; caspase 3 [EC:3.4.22.56]"]
["ENSRNOG00000016575",492,41.39455217,285,18.33417488,2.257781026,1.174905571,{"v":4.38e-29,"d":"4.38E-29"},1.79E-28,"up","yes","Tnfrsf1b","protein_coding","chr5:157070642-157104206:-","gi|30794230|ref|NP_569110.1|",1934,0,"tumor necrosis factor receptor superfamily member 1B precursor [Rattus norvegicus]","gi|32453424|gb|AY191269.1|",5063,0,"Rattus norvegicus TNFR2 transcript variant 3 mRNA, complete cds","Q80WY6",749,0,"Tumor necrosis factor receptor superfamily member 1B",".",".",".",".","pfam00020","TNFR_c6","TNFR/NGFR cysteine-rich region.","GO:0002718|regulation of cytokine production involved in immune response;GO:0002724|regulation of T cell cytokine production;GO:0003176|aortic valve development;GO:0003177|pulmonary valve development;GO:0003332|negative regulation of extracellular matrix constituent secretion;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007166|cell surface receptor signaling pathway;GO:0007568|aging;GO:0008630|intrinsic apoptotic signaling pathway in response to DNA damage;GO:0010614|negative regulation of cardiac muscle hypertrophy;GO:0031641|regulation of myelination;GO:0031643|positive regulation of myelination;GO:0032496|response to lipopolysaccharide;GO:0033209|tumor necrosis factor-mediated signaling pathway;GO:0042129|regulation of T cell proliferation;GO:0048714|positive regulation of oligodendrocyte differentiation;GO:0050728|negative regulation of inflammatory response;GO:0050779|RNA destabilization;GO:0051044|positive regulation of membrane protein ectodomain proteolysis;GO:0060548|negative regulation of cell death;GO:0071222|cellular response to lipopolysaccharide;GO:0071356|cellular response to tumor necrosis factor;GO:0071363|cellular response to growth factor stimulus;GO:0097191|extrinsic apoptotic signaling pathway;GO:0150077|regulation of neuroinflammatory response;GO:0150079|negative regulation of neuroinflammatory response;GO:1901215|negative regulation of neuron death;GO:1902339|positive regulation of apoptotic process involved in morphogenesis;GO:2001141|regulation of RNA biosynthetic process;","GO:0005634|nucleus;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0043025|neuronal cell body;GO:0043196|varicosity;GO:0045121|membrane raft;GO:0048471|perinuclear region of cytoplasm;","GO:0005031|tumor necrosis factor-activated receptor activity;GO:0031625|ubiquitin protein ligase binding;GO:0043120|tumor necrosis factor binding;","K05141","TNFRSF1B, TNFR2, CD120b; tumor necrosis factor receptor superfamily member 1B"]
["ENSRNOG00000032396",123,10.34863804,14,0.900626135,11.49049272,3.522368758,{"v":5.64e-29,"d":"5.64E-29"},2.28E-28,"up","yes","RGD1559575","protein_coding","chr10:33252134-33276225:-","gi|109488030|ref|XP_220362.3|",4236,0,"PREDICTED: uncharacterized protein RGD1559575 [Rattus norvegicus]","gi|672024715|ref|XM_001070154.4|",2936,0,"PREDICTED: Rattus norvegicus similar to novel protein (RGD1559575), mRNA","Q3T9E4",521,{"v":1E-173,"d":"1.00E-173"},"T-cell-specific guanine nucleotide triphosphate-binding protein 2",".",".",".",".","pfam05049","IIGP","Interferon-inducible GTPase (IIGP). Interferon-inducible GTPase (IIGP) is thought to play a role in in intracellular defence. IIGP is predominantly associated with the Golgi apparatus and also localizes to the endoplasmic reticulum and exerts a distinct role in IFN-induced intracellular membrane trafficking or processing.","GO:0006952|defense response;GO:0035458|cellular response to interferon-beta;","GO:0005789|endoplasmic reticulum membrane;","GO:0003924|GTPase activity;GO:0005525|GTP binding;",".","."]
["ENSRNOG00000065741",145,12.19961395,25,1.608260955,7.585593568,2.923262075,{"v":5.88e-29,"d":"5.88E-29"},{"v":2.38e-28,"d":"2.38E-28"},"up","yes","Il7r","protein_coding","chr2:58454217-58477757:-","gi|157823237|ref|NP_001099888.1|",2463,0,"interleukin-7 receptor subunit alpha precursor [Rattus norvegicus]","gi|157823236|ref|NM_001106418.1|",3124,0,"Rattus norvegicus interleukin 7 receptor (Il7r), mRNA","P16872",743,0,"Interleukin-7 receptor subunit alpha",".",".",".",".","pfam00041","fn3","Fibronectin type III domain.",".",".",".",".","."]
["ENSRNOG00000004120",279,23.47373995,112,7.205009077,3.25797507,1.703975564,{"v":6.84e-29,"d":"6.84E-29"},{"v":2.77e-28,"d":"2.77E-28"},"up","yes","ENSRNOG00000004120","protein_coding","chrX:30739413-30740613:+","gi|157818255|ref|NP_001101725.1|",1150,{"v":1e-154,"d":"1.00E-154"},"E3 ubiquitin-protein ligase RNF138-like [Rattus norvegicus]","gi|478733056|ref|NM_001108255.2|",1073,0,"Rattus norvegicus similar to RIKEN cDNA 1700045I19 (RGD1565844), mRNA","Q32LN5",355,{"v":5e-120,"d":"5.00E-120"},"E3 ubiquitin-protein ligase RNF138",".",".",".",".","pfam13923","zf-C3HC4_2","Zinc finger, C3HC4 type (RING finger).","GO:0000724|double-strand break repair via homologous recombination;GO:0008150|biological_process;GO:0010792|DNA double-strand break processing involved in repair via single-strand annealing;GO:0016567|protein ubiquitination;","GO:0005575|cellular_component;GO:0035861|site of double-strand break;","GO:0003674|molecular_function;GO:0003697|single-stranded DNA binding;GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;","K10668","RNF138; E3 ubiquitin-protein ligase RNF138 [EC:2.3.2.27]"]
["ENSRNOG00000033433",561,47.19988571,349,22.45132293,2.102320913,1.071982909,{"v":1.23e-28,"d":"1.23E-28"},{"v":4.92e-28,"d":"4.92E-28"},"up","yes","Csrnp1","protein_coding","chr8:119704713-119718183:-","gi|672063630|ref|XP_008764910.1|",2672,0,"PREDICTED: cysteine/serine-rich nuclear protein 1 isoform X2 [Rattus norvegicus]","gi|672063629|ref|XM_008766688.1|",6212,0,"PREDICTED: Rattus norvegicus cysteine-serine-rich nuclear protein 1 (Csrnp1), transcript variant X1, mRNA","P59054",751,0,"Cysteine/serine-rich nuclear protein 1",".",".",".",".","pfam07223","DUF1421","Protein of unknown function (DUF1421). This family represents a conserved region approximately 350 residues long within a number of plant proteins of unknown function.","GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0009791|post-embryonic development;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048008|platelet-derived growth factor receptor signaling pathway;GO:0048705|skeletal system morphogenesis;GO:0060021|roof of mouth development;GO:0060325|face morphogenesis;","GO:0005634|nucleus;","GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0043565|sequence-specific DNA binding;","K17494","CSRNP; cysteine/serine-rich nuclear protein"]
["ENSRNOG00000019675",227,19.09870598,76,4.889113302,3.906374183,1.965830149,{"v":1.37e-28,"d":"1.37E-28"},{"v":5.48e-28,"d":"5.48E-28"},"up","yes","Pycard","protein_coding","chr1:182601174-182602955:-","gi|149067648|gb|EDM17200.1|",894,{"v":1e-116,"d":"1.00E-116"},"PYD and CARD domain containing [Rattus norvegicus]","gi|298915386|emb|FQ226280.1|",421,0,"Rattus norvegicus TL0AEA2YL13 mRNA sequence","Q9EPB4",273,{"v":8e-89,"d":"8.00E-89"},"Apoptosis-associated speck-like protein containing a CARD",".",".",".",".","pfam02758","PYRIN","PAAD/DAPIN/Pyrin domain. This domain is predicted to contain 6 alpha helices and to have the same fold as the pfam00531 domain. This similarity may mean that this is a protein-protein interaction domain.","GO:0001773|myeloid dendritic cell activation;GO:0002218|activation of innate immune response;GO:0002230|positive regulation of defense response to virus by host;GO:0002277|myeloid dendritic cell activation involved in immune response;GO:0002588|positive regulation of antigen processing and presentation of peptide antigen via MHC class II;GO:0002821|positive regulation of adaptive immune response;GO:0006915|apoptotic process;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006954|inflammatory response;GO:0009617|response to bacterium;GO:0010506|regulation of autophagy;GO:0010803|regulation of tumor necrosis factor-mediated signaling pathway;GO:0030838|positive regulation of actin filament polymerization;GO:0031647|regulation of protein stability;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0032688|negative regulation of interferon-beta production;GO:0032722|positive regulation of chemokine production;GO:0032729|positive regulation of interferon-gamma production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032733|positive regulation of interleukin-10 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0033209|tumor necrosis factor-mediated signaling pathway;GO:0042104|positive regulation of activated T cell proliferation;GO:0042771|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0042981|regulation of apoptotic process;GO:0043065|positive regulation of apoptotic process;GO:0043087|regulation of GTPase activity;GO:0043124|negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043280|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043281|regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0044351|macropinocytosis;GO:0045087|innate immune response;GO:0046330|positive regulation of JNK cascade;GO:0050727|regulation of inflammatory response;GO:0050766|positive regulation of phagocytosis;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:0050870|positive regulation of T cell activation;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051260|protein homooligomerization;GO:0051607|defense response to virus;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071222|cellular response to lipopolysaccharide;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071901|negative regulation of protein serine/threonine kinase activity;GO:0072332|intrinsic apoptotic signaling pathway by p53 class mediator;GO:0090200|positive regulation of release of cytochrome c from mitochondria;GO:0097202|activation of cysteine-type endopeptidase activity;GO:1900016|negative regulation of cytokine production involved in inflammatory response;GO:2000406|positive regulation of T cell migration;GO:2001056|positive regulation of cysteine-type endopeptidase activity;GO:2001238|positive regulation of extrinsic apoptotic signaling pathway;GO:2001242|regulation of intrinsic apoptotic signaling pathway;","GO:0000139|Golgi membrane;GO:0005576|extracellular region;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;GO:0008385|IkappaB kinase complex;GO:0032991|protein-containing complex;GO:0043025|neuronal cell body;GO:0061702|inflammasome complex;GO:0072558|NLRP1 inflammasome complex;GO:0072559|NLRP3 inflammasome complex;GO:0097169|AIM2 inflammasome complex;","GO:0002020|protease binding;GO:0005138|interleukin-6 receptor binding;GO:0005515|protein binding;GO:0005523|tropomyosin binding;GO:0017024|myosin I binding;GO:0019899|enzyme binding;GO:0032090|Pyrin domain binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0044325|ion channel binding;GO:0046983|protein dimerization activity;GO:0070700|BMP receptor binding;GO:0097153|cysteine-type endopeptidase activity involved in apoptotic process;","K12799","PYCARD, ASC; apoptosis-associated speck-like protein containing a CARD"]
["ENSRNOG00000065128",100,8.413526865,4,0.257321753,32.696524,5.031065364,1.62E-28,6.45E-28,"up","yes","Naip5","protein_coding","chr2:31557817-31608634:-","gi|109464318|ref|XP_226743.4|",7285,0,"PREDICTED: baculoviral IAP repeat-containing protein 1e-like [Rattus norvegicus]","gi|672041321|ref|XM_226743.6|",5828,0,"PREDICTED: Rattus norvegicus NLR family, apoptosis inhibitory protein 5 (Naip5), transcript variant X1, mRNA","Q9R016",2324,0,"Baculoviral IAP repeat-containing protein 1e",".",".",".",".","pfam05729","NACHT","NACHT domain. This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.",".",".",".",".","."]
["ENSRNOG00000007918",190,15.98570104,53,3.409513224,4.688558159,2.229144328,{"v":4.08e-28,"d":"4.08E-28"},1.61E-27,"up","yes","Tbxas1","protein_coding","chr4:67665007-67837096:+","gi|6981634|ref|NP_036819.1|",2590,0,"thromboxane-A synthase [Rattus norvegicus]","gi|6981633|ref|NM_012687.1|",1813,0,"Rattus norvegicus thromboxane A synthase 1 (Tbxas1), mRNA","P49430",998,0,"Thromboxane-A synthase","VNG0422G",126,{"v":1e-30,"d":"1.00E-30"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0001516|prostaglandin biosynthetic process;GO:0006690|icosanoid metabolic process;GO:0030644|cellular chloride ion homeostasis;GO:0045471|response to ethanol;GO:0045907|positive regulation of vasoconstriction;GO:0070542|response to fatty acid;","GO:0005575|cellular_component;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0004497|monooxygenase activity;GO:0004796|thromboxane-A synthase activity;GO:0005506|iron ion binding;GO:0016705|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0020037|heme binding;GO:0036134|12-hydroxyheptadecatrienoic acid synthase activity;","K01832","TBXAS1, CYP5A; thromboxane-A synthase [EC:5.3.99.5]"]
["ENSRNOG00000014357",278,23.38960468,114,7.333669953,3.189345148,1.673260233,{"v":4.19e-28,"d":"4.19E-28"},1.65E-27,"up","yes","Gja4","protein_coding","chr5:139633287-139635925:-","gi|11067369|ref|NP_067686.1|",1627,0,"gap junction alpha-4 protein [Rattus norvegicus]","gi|51036648|ref|NM_021654.2|",1590,0,"Rattus norvegicus gap junction protein, alpha 4 (Gja4), mRNA","Q03190",631,0,"Gap junction alpha-4 protein",".",".",".",".","pfam00029","Connexin","Connexin.","GO:0001568|blood vessel development;GO:0003158|endothelium development;GO:0006816|calcium ion transport;GO:0007154|cell communication;GO:0007267|cell-cell signaling;GO:0048265|response to pain;GO:0055085|transmembrane transport;","GO:0005921|gap junction;GO:0005922|connexin complex;GO:0016021|integral component of membrane;","GO:0005243|gap junction channel activity;","K07613","GJA4, CX37; gap junction alpha-4 protein"]
["ENSRNOG00000046699",126,10.60104385,17,1.093617449,9.693557704,3.277026257,{"v":4.98e-28,"d":"4.98E-28"},{"v":1.96e-27,"d":"1.96E-27"},"up","yes","Slpi","protein_coding","chr3:153082369-153084453:-","gi|149042957|gb|EDL96531.1|",659,{"v":8e-86,"d":"8.00E-86"},"rCG32428, isoform CRA_a [Rattus norvegicus]","gi|23451267|gb|AF421377.1|",444,0,"Rattus norvegicus secretory leukocyte protease inhibitor precursor, mRNA, complete cds","P97430",217,{"v":3e-71,"d":"3.00E-71"},"Antileukoproteinase",".",".",".",".","pfam00095","WAP","WAP-type (Whey Acidic Protein) 'four-disulfide core'.","GO:0006955|immune response;GO:0010951|negative regulation of endopeptidase activity;GO:0019731|antibacterial humoral response;GO:0032091|negative regulation of protein binding;GO:0032496|response to lipopolysaccharide;GO:0035821|modification of morphology or physiology of other organism;GO:0045071|negative regulation of viral genome replication;GO:0045087|innate immune response;GO:0050728|negative regulation of inflammatory response;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005794|Golgi apparatus;","GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0003729|mRNA binding;GO:0004866|endopeptidase inhibitor activity;GO:0004867|serine-type endopeptidase inhibitor activity;GO:0019899|enzyme binding;","K23638","SLPI, WFDC4; antileukoproteinase"]
["ENSRNOG00000003064",180,15.14434836,47,3.023530595,5.008829209,2.324473419,{"v":5.01e-28,"d":"5.01E-28"},{"v":1.96e-27,"d":"1.96E-27"},"up","yes","Bst1","protein_coding","chr14:67252998-67270180:-","gi|13540658|ref|NP_110475.1|",1366,0,"ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 precursor [Rattus norvegicus]","gi|74208693|dbj|AK164028.1|",994,0,"Mus musculus 7 days embryo whole body cDNA, RIKEN full-length enriched library, clone:C430019G14 product:bone marrow stromal cell antigen 1, full insert sequence","Q63072",529,0,"ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2",".",".",".",".","pfam02267","Rib_hydrolayse","ADP-ribosyl cyclase. ADP-ribosyl cyclase EC:3.2.2.5 (also know as cyclic ADP-ribose hydrolase or CD38) synthesizes cyclic-ADP ribose, a second messenger for glucose-induced insulin secretion.","GO:0001952|regulation of cell-matrix adhesion;GO:0008150|biological_process;GO:0008284|positive regulation of cell proliferation;GO:0030890|positive regulation of B cell proliferation;GO:0032956|regulation of actin cytoskeleton organization;GO:0050727|regulation of inflammatory response;GO:0050730|regulation of peptidyl-tyrosine phosphorylation;GO:0050848|regulation of calcium-mediated signaling;GO:0090022|regulation of neutrophil chemotaxis;","GO:0001931|uropod;GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0019898|extrinsic component of membrane;GO:0031225|anchored component of membrane;","GO:0003674|molecular_function;GO:0003953|NAD+ nucleosidase activity;GO:0016740|transferase activity;GO:0016849|phosphorus-oxygen lyase activity;GO:0050135|NAD(P)+ nucleosidase activity;GO:0061809|NAD+ nucleotidase, cyclic ADP-ribose generating;GO:0061811|ADP-ribosyl cyclase activity;GO:0061812|cyclic ADP-ribose hydrolase;","K18152","BST1, CD157; ADP-ribosyl cyclase 2 [EC:3.2.2.6 2.4.99.20]"]
["ENSRNOG00000015895",403,33.90651326,214,13.76671377,2.462934425,1.300378217,{"v":5.24e-28,"d":"5.24E-28"},{"v":2.06e-27,"d":"2.06E-27"},"up","yes","B4galt6","protein_coding","chr18:11958390-12015247:-","gi|13929042|ref|NP_113928.1|",1987,0,"beta-1,4-galactosyltransferase 6 [Rattus norvegicus]","gi|13929041|ref|NM_031740.1|",5589,0,"Rattus norvegicus UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6 (B4galt6), mRNA","O88419",769,0,"Beta-1,4-galactosyltransferase 6",".",".",".",".","pfam13733","Glyco_transf_7N","N-terminal region of glycosyl transferase group 7. This is the N-terminal half of a family of galactosyltransferases from a wide range of Metazoa with three related galactosyltransferases activities, all three of which are possessed by one sequence in some cases. EC:2.4.1.90, N-acetyllactosamine synthase; EC:2.4.1.38, Beta-N-acetylglucosaminyl-glycopeptide beta-1,4- galactosyltransferase; and EC:2.4.1.22 Lactose synthase. Note that N-acetyllactosamine synthase is a component of Lactose synthase along with alpha-lactalbumin, in the absence of alpha-lactalbumin EC:2.4.1.90 is the catalysed reaction.","GO:0001572|lactosylceramide biosynthetic process;GO:0005975|carbohydrate metabolic process;GO:0006486|protein glycosylation;GO:0006688|glycosphingolipid biosynthetic process;GO:0010706|ganglioside biosynthetic process via lactosylceramide;GO:0021955|central nervous system neuron axonogenesis;GO:0022010|central nervous system myelination;GO:0042551|neuron maturation;GO:0070085|glycosylation;","GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;GO:0032580|Golgi cisterna membrane;","GO:0008378|galactosyltransferase activity;GO:0008489|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity;GO:0016757|transferase activity, transferring glycosyl groups;GO:0046872|metal ion binding;","K07553","B4GALT6; beta-1,4-galactosyltransferase 6 [EC:2.4.1.274]"]
["ENSRNOG00000000172",233,19.60351759,82,5.275095931,3.716239069,1.893843315,5.81E-28,{"v":2.27e-27,"d":"2.27E-27"},"up","yes","Sqor","protein_coding","chr3:109841250-109960778:+","gi|209862751|ref|NP_001041378.2|",2329,0,"sulfide:quinone oxidoreductase, mitochondrial [Rattus norvegicus]","gi|672046990|ref|XM_006234887.2|",1402,0,"PREDICTED: Rattus norvegicus sulfide quinone reductase-like (yeast) (Sqrdl), transcript variant X1, mRNA","Q9R112",845,0,"Sulfide:quinone oxidoreductase, mitochondrial","SA0084",421,{"v":4e-140,"d":"4.00E-140"},"COG0446","pfam13738","Pyr_redox_3","Pyridine nucleotide-disulphide oxidoreductase.","GO:0070221|sulfide oxidation, using sulfide:quinone oxidoreductase;GO:0070813|hydrogen sulfide metabolic process;","GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;","GO:0070224|sulfide:quinone oxidoreductase activity;GO:0071949|FAD binding;","K22470","SQOR; eukaryotic sulfide quinone oxidoreductase [EC:1.8.5.8]"]
["ENSRNOG00000019819",476,40.04838788,277,17.81953138,2.247443383,1.168284772,{"v":5.91e-28,"d":"5.91E-28"},{"v":2.31e-27,"d":"2.31E-27"},"up","yes","Dus2","protein_coding","chr19:33911750-33954709:+","gi|157818491|ref|NP_001099651.1|",2494,0,"tRNA-dihydrouridine(20) synthase [NAD(P)+]-like [Rattus norvegicus]","gi|157818490|ref|NM_001106181.1|",1936,0,"Rattus norvegicus dihydrouridine synthase 2 (Dus2), mRNA","Q9D7B1",946,0,"tRNA-dihydrouridine(20) synthase [NAD(P)+]-like","SPBC1709.06",203,{"v":1E-56,"d":"1.00E-56"},"COG0042","pfam01207","Dus","Dihydrouridine synthase (Dus). Members of this family catalyse the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also in some archae. Most dihydrouridines are found in the D loop of t-RNAs. The role of dihydrouridine in tRNA is currently unknown, but may increase conformational flexibility of the tRNA. It is likely that different family members have different substrate specificities, which may overlap. Dus 1 from Saccharomyces cerevisiae acts on pre-tRNA-Phe, while Dus 2 acts on pre-tRNA-Tyr and pre-tRNA-Leu. Dus 1 is active as a single subunit, requiring NADPH or NADH, and is stimulated by the presence of FAD. Some family members may be targeted to the mitochondria and even have a role in mitochondria.","GO:0002943|tRNA dihydrouridine synthesis;GO:0043086|negative regulation of catalytic activity;GO:0060548|negative regulation of cell death;","GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0000049|tRNA binding;GO:0003725|double-stranded RNA binding;GO:0004860|protein kinase inhibitor activity;GO:0010181|FMN binding;GO:0017150|tRNA dihydrouridine synthase activity;GO:0050660|flavin adenine dinucleotide binding;GO:0070402|NADPH binding;","K05543","DUS2; tRNA-dihydrouridine synthase 2 [EC:1.3.1.91]"]
["ENSRNOG00000005935",265,22.29584619,105,6.754696009,3.300791947,1.722812207,6.29E-28,{"v":2.46e-27,"d":"2.46E-27"},"up","yes","A3galt2","protein_coding","chr5:141107983-141115641:+","gi|19924055|ref|NP_612533.1|",1776,0,"alpha-1,3-galactosyltransferase 2 [Rattus norvegicus]","gi|40254730|ref|NM_138524.2|",1814,0,"Rattus norvegicus alpha 1,3-galactosyltransferase 2 (A3galt2), mRNA","A0A4Z3",688,0,"Alpha-1,3-galactosyltransferase 2",".",".",".",".","pfam03414","Glyco_transf_6","Glycosyltransferase family 6.","GO:0005975|carbohydrate metabolic process;GO:0006688|glycosphingolipid biosynthetic process;GO:0030259|lipid glycosylation;GO:0071287|cellular response to manganese ion;","GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;GO:0031982|vesicle;GO:0032580|Golgi cisterna membrane;","GO:0001962|alpha-1,3-galactosyltransferase activity;GO:0016757|transferase activity, transferring glycosyl groups;GO:0046872|metal ion binding;GO:0047276|N-acetyllactosaminide 3-alpha-galactosyltransferase activity;","K20736","A3GALT2; alpha-1,3-galactosyltransferase 2 [EC:2.4.1.87]"]
["ENSRNOG00000038129",110,9.254879551,0,0.032165219,287.7294112,8.168568888,{"v":6.49e-28,"d":"6.49E-28"},{"v":2.54e-27,"d":"2.54E-27"},"up","yes","Defb52","protein_coding","chr16:70588116-70590626:+","gi|564389783|ref|XP_006253430.1|",551,{"v":5e-70,"d":"5.00E-70"},"PREDICTED: beta-defensin 52 isoform X1 [Rattus norvegicus]","gi|672080546|ref|XM_006253368.2|",415,0,"PREDICTED: Rattus norvegicus defensin beta 52 (Defb52), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam01537","Herpes_glycop_D","Herpesvirus glycoprotein D/GG/GX domain. This domain is found in several Herpes viruses glycoproteins. This is a family includes glycoprotein-D (gD or gIV) which is common to herpes simplex virus types 1 and 2, as well as equine herpes, bovine herpes and Marek's disease virus. Glycoprotein-D has been found on the viral envelope and the plasma membrane of infected cells. and gD immunisation can produce an immune response to bovine herpes virus (BHV-1). This response is stronger than that of the other major glycoproteins gB (gI) and gC (gIII) in BHV-1. Glycoprotein G (gG)is one of the seven external glycoproteins of HSV1 and HSV2. This family also contains the glycoprotein GX, (gX), initially identified in Pseudorabies virus.",".",".",".",".","."]
["ENSRNOG00000001874",349,29.36320876,170,10.93617449,2.684961618,1.424901465,{"v":6.73e-28,"d":"6.73E-28"},{"v":2.63e-27,"d":"2.63E-27"},"up","yes","Slc7a4","protein_coding","chr11:83435211-83438881:+","gi|157819067|ref|NP_001100548.1|",2615,0,"cationic amino acid transporter 4 [Rattus norvegicus]","gi|672071714|ref|XM_006248697.2|",2465,0,"PREDICTED: Rattus norvegicus solute carrier family 7, member 4 (Slc7a4), transcript variant X4, mRNA","Q8BLQ7",991,0,"Cationic amino acid transporter 4","BS_yfnA",183,{"v":3E-49,"d":"3.00E-49"},"COG0531","pfam13520","AA_permease_2","Amino acid permease.","GO:0003333|amino acid transmembrane transport;GO:0006865|amino acid transport;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0015171|amino acid transmembrane transporter activity;","K13866","SLC7A4; solute carrier family 7 (cationic amino acid transporter), member 4"]
["ENSRNOG00000036711",181,15.22848363,48,3.087861033,4.931725704,2.302092561,7.22E-28,{"v":2.81e-27,"d":"2.81E-27"},"up","yes","Spn","protein_coding","chr1:181746429-181759628:-","gi|402747140|ref|NP_001258015.1|",1433,{"v":2E-180,"d":"2.00E-180"},"leukosialin precursor [Rattus norvegicus]","gi|672038365|ref|XM_008759858.1|",4281,0,"PREDICTED: Rattus norvegicus sialophorin (Spn), transcript variant X2, mRNA","P13838",541,{"v":1E-176,"d":"1.00E-176"},"Leukosialin (Fragment)",".",".",".",".","pfam05109","Herpes_BLLF1","Herpes virus major outer envelope glycoprotein (BLLF1). This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralizing antibodies in vivo.","GO:0001562|response to protozoan;GO:0001808|negative regulation of type IV hypersensitivity;GO:0001934|positive regulation of protein phosphorylation;GO:0002296|T-helper 1 cell lineage commitment;GO:0002544|chronic inflammatory response;GO:0007162|negative regulation of cell adhesion;GO:0007166|cell surface receptor signaling pathway;GO:0010468|regulation of gene expression;GO:0031295|T cell costimulation;GO:0032760|positive regulation of tumor necrosis factor production;GO:0042102|positive regulation of T cell proliferation;GO:0042117|monocyte activation;GO:0042130|negative regulation of T cell proliferation;GO:0042742|defense response to bacterium;GO:0045060|negative thymic T cell selection;GO:0050688|regulation of defense response to virus;GO:0050776|regulation of immune response;GO:0050852|T cell receptor signaling pathway;GO:0050863|regulation of T cell activation;GO:0050868|negative regulation of T cell activation;GO:0050901|leukocyte tethering or rolling;GO:0071594|thymocyte aggregation;GO:0097190|apoptotic signaling pathway;GO:2000404|regulation of T cell migration;GO:2000406|positive regulation of T cell migration;","GO:0001931|uropod;GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0005887|integral component of plasma membrane;GO:0005902|microvillus;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016605|PML body;GO:0032154|cleavage furrow;","GO:0004888|transmembrane signaling receptor activity;GO:0005515|protein binding;GO:0019904|protein domain specific binding;GO:0030544|Hsp70 protein binding;GO:0031072|heat shock protein binding;","K06477","SPN, CD43; sialophorin"]
["ENSRNOG00000000451",314,26.41847435,143,9.19925266,2.871806584,1.521958587,1.06E-27,{"v":4.1e-27,"d":"4.10E-27"},"up","yes","RT1-Ba","protein_coding","chr20:4575134-4579744:+","gi|57012346|ref|NP_001008831.1|",1105,{"v":1E-146,"d":"1.00E-146"},"rano class II histocompatibility antigen, B alpha chain precursor [Rattus norvegicus]","gi|89214481|gb|AC120734.5|",705,0,"Rattus norvegicus BAC CH230-220D1 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P20037",380,{"v":8e-129,"d":"8.00E-129"},"Rano class II histocompatibility antigen, B alpha chain",".",".",".",".","pfam00993","MHC_II_alpha","Class II histocompatibility antigen, alpha domain.","GO:0002250|adaptive immune response;GO:0002381|immunoglobulin production involved in immunoglobulin mediated immune response;GO:0002503|peptide antigen assembly with MHC class II protein complex;GO:0019882|antigen processing and presentation;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0034341|response to interferon-gamma;GO:0042130|negative regulation of T cell proliferation;GO:0045582|positive regulation of T cell differentiation;GO:0048002|antigen processing and presentation of peptide antigen;GO:0050870|positive regulation of T cell activation;GO:0071385|cellular response to glucocorticoid stimulus;","GO:0005575|cellular_component;GO:0005764|lysosome;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0042613|MHC class II protein complex;","GO:0023026|MHC class II protein complex binding;GO:0042605|peptide antigen binding;GO:0044877|protein-containing complex binding;","K06752","MHC2; MHC class II antigen"]
["ENSRNOG00000062678",151,12.70442557,31,1.994243584,6.370548547,2.671417604,1.45E-27,{"v":5.6e-27,"d":"5.60E-27"},"up","yes","H19","protein_coding","chr1:197730698-197733134:-","gi|111797|pir||S15484",448,{"v":7e-59,"d":"7.00E-59"},"hypothetical protein - rat","gi|224922740|ref|NR_027324.1|",2031,0,"Rattus norvegicus H19, imprinted maternally expressed transcript (non-protein coding) (H19), long non-coding RNA",".",".",".",".",".",".",".",".","pfam15252","DUF4589","Domain of unknown function (DUF4589). This protein family is a domain of unknown function. The precise function of the protein domain remains to be elucidated. This family of proteins is found in eukaryotes and are typically between 215 and 293 amino acids in length. The protein contains two conserved sequence motifs: SSS and KST.",".",".",".",".","."]
["ENSRNOG00000062002",132,11.10585546,21,1.350939202,8.22084032,3.039285871,{"v":1.84e-27,"d":"1.84E-27"},{"v":7.05e-27,"d":"7.05E-27"},"up","yes","Kcna3","protein_coding","chr2:194632196-194650138:+","gi|795363234|ref|XP_011933735.1|",2221,0,"PREDICTED: potassium voltage-gated channel subfamily A member 3 [Cercocebus atys]","gi|880918565|ref|XM_005076595.2|",3873,0,"PREDICTED: Mesocricetus auratus potassium channel, voltage gated shaker related subfamily A, member 3 (Kcna3), mRNA","P22001",853,0,"Potassium voltage-gated channel subfamily A member 3","DR0830",77,{"v":8E-14,"d":"8.00E-14"},"COG1226","pfam02214","BTB_2","BTB/POZ domain. In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.","GO:0006813|potassium ion transport;GO:0034765|regulation of ion transmembrane transport;GO:0051260|protein homooligomerization;GO:0071805|potassium ion transmembrane transport;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0008076|voltage-gated potassium channel complex;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0044305|calyx of Held;GO:0045121|membrane raft;GO:0098978|glutamatergic synapse;GO:0099055|integral component of postsynaptic membrane;GO:0099056|integral component of presynaptic membrane;","GO:0005249|voltage-gated potassium channel activity;GO:0005251|delayed rectifier potassium channel activity;GO:0005515|protein binding;GO:0015271|outward rectifier potassium channel activity;","K04876","KCNA3, KV1.3; potassium voltage-gated channel Shaker-related subfamily A member 3"]
["ENSRNOG00000069960",130,10.93758492,20,1.286608764,8.50109624,3.087648893,{"v":1.89e-27,"d":"1.89E-27"},{"v":7.24e-27,"d":"7.24E-27"},"up","yes","5_8S_rRNA","rRNA","chr3:2234750-2234902:+","gi|954258002|gb|KRX51787.1|",138,{"v":1E-8,"d":"1.00E-08"},"hypothetical protein T09_8305 [Trichinella sp. T9]","gi|958786664|ref|XM_014867045.1|",153,{"v":3e-73,"d":"3.00E-73"},"PREDICTED: Equus asinus translation initiation factor IF-2-like (LOC106847650), mRNA",".",".",".",".",".",".",".",".","pfam05346","DUF747","Eukaryotic membrane protein family. This family is a family of eukaryotic membrane proteins. It was previously annotated as including a putative receptor for human cytomegalovirus gH but this has has since been disputed. Analysis of the mouse Tapt1 protein (transmembrane anterior posterior transformation 1) has shown it to be involved in patterning of the vertebrate axial skeleton.",".",".",".",".","."]
["ENSRNOG00000016978",115,9.675555894,13,0.836295696,11.56953926,3.532259508,{"v":2.97e-27,"d":"2.97E-27"},1.13E-26,"up","yes","ENSRNOG00000016978","protein_coding","chr1:181702503-181705835:+","gi|68163457|ref|NP_001020172.1|",1039,{"v":7e-131,"d":"7.00E-131"},"transmembrane protein C16orf54 homolog [Rattus norvegicus]","gi|68163456|ref|NM_001025001.1|",2149,0,"Rattus norvegicus hypothetical protein LOC308990 (LOC308990), mRNA","Q5BK39",404,{"v":2E-132,"d":"2.00E-132"},"Transmembrane protein C16orf54 homolog",".",".",".",".","pfam06398","Pex24p","Integral peroxisomal membrane peroxin. Peroxisomes play diverse roles in the cell, compartmentalising many activities related to lipid metabolizm and functioning in the decomposition of toxic hydrogen peroxide. Sequence similarity was identified between two hypothetical proteins and the peroxin integral membrane protein Pex24p.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000013415",275,23.13719888,115,7.398000391,3.1274936,1.645006932,{"v":3.43e-27,"d":"3.43E-27"},1.31E-26,"up","yes","Ptpn18","protein_coding","chr9:36672362-36690995:+","gi|61556976|ref|NP_001013129.1|",2183,0,"tyrosine-protein phosphatase non-receptor type 18 [Rattus norvegicus]","gi|1669507|gb|U69673.1|RNU69673",1368,0,"Rattus norvegicus protein tyrosine phosphatase 20 mRNA, complete cds","Q61152",781,0,"Tyrosine-protein phosphatase non-receptor type 18","SPAC19D5.01",140,{"v":1e-33,"d":"1.00E-33"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0001825|blastocyst formation;GO:0035335|peptidyl-tyrosine dephosphorylation;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0004725|protein tyrosine phosphatase activity;GO:0004726|non-membrane spanning protein tyrosine phosphatase activity;","K18024","PTPN12_18_22; tyrosine-protein phosphatase non-receptor type 12/18/22 [EC:3.1.3.48]"]
["ENSRNOG00000013886",235,19.77178813,86,5.532417684,3.573806112,1.837461367,{"v":4e-27,"d":"4.00E-27"},1.52E-26,"up","yes","Fyb1","protein_coding","chr2:55632698-55779629:+","gi|564335481|ref|XP_006232081.1|",3301,0,"PREDICTED: FYN-binding protein isoform X4 [Rattus norvegicus]","gi|672041620|ref|XR_590914.1|",3565,0,"PREDICTED: Rattus norvegicus FYN binding protein (Fyb), transcript variant X7, misc_RNA","O35601",1118,0,"FYN-binding protein 1",".",".",".",".","pfam14603","hSH3","Helically-extended SH3 domain. This domain is the 70 C-terminal residues of ADAP - Adhesion and de-granulation promoting adapter protein. It shows homology to SH3 domains; however, conserved residues of the fold are absent. It thus represents an altered SH3 domain fold. An N-terminal, amphipathic, helix makes extensive contacts to residues of the regular SH3 domain fold thereby creating a composite surface with unusual surface properties. The domain can no longer bind conventional proline-rich peptides. There are key phosphorylation sites within the two hSH3 domains and it would appear that binding at these sites does not materially affect the folding of these regions although the equilibrium towards the unfolded state may be slightly altered. The binding partners of the hSH3 domains are still unknown.","GO:0006955|immune response;GO:0007229|integrin-mediated signaling pathway;GO:0050852|T cell receptor signaling pathway;GO:0072659|protein localization to plasma membrane;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0015629|actin cytoskeleton;GO:0030054|cell junction;GO:0032991|protein-containing complex;","GO:0008289|lipid binding;GO:0044877|protein-containing complex binding;","K17698","FYB, ADAP; FYN binding protein"]
["ENSRNOG00000012442",298,25.07231006,133,8.555948279,2.930395234,1.55109526,4.52E-27,1.71E-26,"up","yes","Cemip","protein_coding","chr1:137908920-138062415:-","gi|109458933|ref|XP_218855.4|",7494,0,"PREDICTED: cell migration-inducing and hyaluronan-binding protein isoform X1 [Rattus norvegicus]","gi|672013943|ref|XM_001063314.5|",5079,0,"PREDICTED: Rattus norvegicus cell migration inducing protein, hyaluronan binding (Cemip), transcript variant X1, mRNA","Q8BI06",2793,0,"Cell migration-inducing and hyaluronan-binding protein",".",".",".",".","pfam10162","G8","G8 domain. This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.","GO:0007605|sensory perception of sound;GO:0010800|positive regulation of peptidyl-threonine phosphorylation;GO:0030214|hyaluronan catabolic process;GO:0030335|positive regulation of cell migration;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;GO:0090314|positive regulation of protein targeting to membrane;GO:1900020|positive regulation of protein kinase C activity;","GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0030665|clathrin-coated vesicle membrane;GO:0045334|clathrin-coated endocytic vesicle;","GO:0004415|hyalurononglucosaminidase activity;GO:0005540|hyaluronic acid binding;GO:0032050|clathrin heavy chain binding;GO:0046923|ER retention sequence binding;","K19031","CEMIP, KIAA1199; cell migration-inducing and hyaluronan-binding protein [EC:3.2.1.35]"]
["ENSRNOG00000052064",184,15.48088943,52,3.345182786,4.627815705,2.210331413,5.16E-27,{"v":1.95e-26,"d":"1.95E-26"},"up","yes","Parvg","protein_coding","chr7:115456209-115475104:+","gi|194474058|ref|NP_001124055.1|",1661,0,"gamma-parvin [Rattus norvegicus]","gi|194474057|ref|NM_001130583.1|",2536,0,"Rattus norvegicus parvin, gamma (Parvg), mRNA","Q9ERD8",592,0,"Gamma-parvin",".",".",".",".","pfam00307","CH","Calponin homology (CH) domain. The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.","GO:0007163|establishment or maintenance of cell polarity;GO:0030031|cell projection assembly;GO:0031532|actin cytoskeleton reorganization;GO:0034446|substrate adhesion-dependent cell spreading;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005925|focal adhesion;GO:0015629|actin cytoskeleton;","GO:0003779|actin binding;","K06275","PARV; parvin"]
["ENSRNOG00000046468",478,40.21665841,284,18.26984444,2.20125894,1.138328863,{"v":5.45e-27,"d":"5.45E-27"},{"v":2.06e-26,"d":"2.06E-26"},"up","yes","Ptgfr","protein_coding","chr2:240733375-240765650:-","gi|6981436|ref|NP_037247.1|",1826,0,"prostaglandin F2-alpha receptor [Rattus norvegicus]","gi|6981435|ref|NM_013115.1|",2979,0,"Rattus norvegicus prostaglandin F receptor (Ptgfr), mRNA","P43118",707,0,"Prostaglandin F2-alpha receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0006954|inflammatory response;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0008284|positive regulation of cell proliferation;GO:0010628|positive regulation of gene expression;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0035584|calcium-mediated signaling using intracellular calcium source;GO:0043066|negative regulation of apoptotic process;GO:0071799|cellular response to prostaglandin D stimulus;","GO:0005576|extracellular region;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004958|prostaglandin F receptor activity;","K04262","PTGFR; prostaglandin F receptor"]
["ENSRNOG00000068731",118,9.9279617,15,0.964956573,10.28850622,3.362961628,{"v":6.66e-27,"d":"6.66E-27"},{"v":2.5e-26,"d":"2.50E-26"},"up","yes","ENSRNOG00000068731","lncRNA","chr5:145217884-145221870:+","gi|148704753|gb|EDL36700.1|",232,{"v":7e-19,"d":"7.00E-19"},"mCG146313, partial [Mus musculus]","gi|23956420|emb|AL627184.18|",580,0,"Mouse DNA sequence from clone RP23-125F21 on chromosome 4, complete sequence",".",".",".",".",".",".",".",".","pfam15180","NPBW","Neuropeptides B and W. The function of this family, NPBW, which includes Neuropeptides B and W, is thought to be involved in activating G-protein coupled receptors, GPR7 and GPR8. It is thought to play a regulatory role in the organisation of neuroendocrine signals accessing the anterior pituitary gland. It is predicted that this effect will stimulate the increase in water-drinking and food-intake. This suggests it plays a role in the hypothalamic response to stress. This family of proteins is found in eukaryotes.",".",".",".",".","."]
["ENSRNOG00000010134",438,36.85124767,250,16.08260955,2.291372402,1.19621195,{"v":8.81e-27,"d":"8.81E-27"},{"v":3.3e-26,"d":"3.30E-26"},"up","yes","Acot2","protein_coding","chr6:103611544-103619245:+","gi|6166586|sp|O55171.1|ACOT2_RAT",2216,0,"RecName: Full=Acyl-coenzyme A thioesterase 2, mitochondrial; Short=Acyl-CoA thioesterase 2; AltName: Full=ARTISt/p43; AltName: Full=Acyl coenzyme A thioester hydrolase; AltName: Full=MTE-I; AltName: Full=Very-long-chain acyl-CoA thioesterase; Flags: Precursor","gi|48675861|ref|NM_138907.2|",2366,0,"Rattus norvegicus acyl-CoA thioesterase 2 (Acot2), mRNA","O55171",858,0,"Acyl-coenzyme A thioesterase 2, mitochondrial","CAC3407",144,{"v":6e-36,"d":"6.00E-36"},"COG1073","pfam08840","BAAT_C","BAAT / Acyl-CoA thioester hydrolase C terminal. This catalytic domain is found at the C terminal of acyl-CoA thioester hydrolases and bile acid-CoA:amino acid N-acetyltransferases (BAAT).","GO:0000038|very long-chain fatty acid metabolic process;GO:0001666|response to hypoxia;GO:0001676|long-chain fatty acid metabolic process;GO:0006631|fatty acid metabolic process;GO:0006637|acyl-CoA metabolic process;GO:0009410|response to xenobiotic stimulus;GO:0009725|response to hormone;GO:0031667|response to nutrient levels;GO:0042760|very long-chain fatty acid catabolic process;GO:0070849|response to epidermal growth factor;","GO:0005739|mitochondrion;GO:0005759|mitochondrial matrix;","GO:0016290|palmitoyl-CoA hydrolase activity;GO:0016790|thiolester hydrolase activity;GO:0047617|acyl-CoA hydrolase activity;GO:0052689|carboxylic ester hydrolase activity;GO:0102991|myristoyl-CoA hydrolase activity;","K01068","ACOT1_2_4; acyl-coenzyme A thioesterase 1/2/4 [EC:3.1.2.2]"]
["ENSRNOG00000023143",359,30.20456144,184,11.83680063,2.55175046,1.351487252,{"v":1.45e-26,"d":"1.45E-26"},{"v":5.38e-26,"d":"5.38E-26"},"up","yes","Nlrp1a","protein_coding","chr10:55778560-55825180:-","gi|451770406|ref|NP_001139227.2|",6329,0,"NLR family, pyrin domain containing 1A [Rattus norvegicus]","gi|672067974|ref|XM_006246755.2|",7024,0,"PREDICTED: Rattus norvegicus NLR family, pyrin domain containing 1A (Nlrp1a), transcript variant X1, mRNA","Q2LKU9",1782,0,"NACHT, LRR and PYD domains-containing protein 1a",".",".",".",".","pfam13553","FIIND","Function to find. The function to find (FIIND) was initially discovered in two proteins, NLRP1 (aka NALP1, CARD7, NAC, DEFCAP) and CARD8 (aka TUCAN, Cardinal). NLRP1 is a member of the Nod-like receptor (NLR) protein superfamily and is involved in apoptosis and inflammation. To date, it is the only NLR protein known to have a FIIND domain. The FIIND domain is also present in the CARD8 protein where, like in NLRP1, it is followed by a C-terminal CARD domain. Both proteins are described  to form an \"inflammasome\", a macro-molecular complex able to process caspase 1 and activate pro-IL1beta. The FIIND domain is present in only a very small subset of the kingdom of life, comprising primates, rodents (mouse, rat), carnivores (dog) and a few more,  such as horse. The function of this domain is yet to be determined. Publications describing the newly discovered NLRP1 protein failed to identify it as a separate domain; for example, it was taken as part of the adjacent leucine rich repeat domain (LRR). Upon discovery of CARD8 it was noted that the N-terminal region shared significant sequence identity with an undescribed region in NLRP1. Before getting its final name, FIIND, this domain was termed NALP1-associated domain (NAD).","GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006954|inflammatory response;GO:0032495|response to muramyl dipeptide;GO:0032731|positive regulation of interleukin-1 beta production;GO:0042742|defense response to bacterium;GO:0042981|regulation of apoptotic process;GO:0051245|negative regulation of cellular defense response;GO:0051260|protein homooligomerization;GO:0051402|neuron apoptotic process;GO:0051607|defense response to virus;GO:0070269|pyroptosis;GO:0097264|self proteolysis;GO:0097300|programmed necrotic cell death;GO:1904784|NLRP1 inflammasome complex assembly;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0032991|protein-containing complex;GO:0043025|neuronal cell body;GO:0072558|NLRP1 inflammasome complex;","GO:0003690|double-stranded DNA binding;GO:0003725|double-stranded RNA binding;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0008233|peptidase activity;GO:0019899|enzyme binding;GO:0019904|protein domain specific binding;GO:0043621|protein self-association;GO:0097110|scaffold protein binding;","K12798","NLRP1, CARD7; NACHT, LRR and PYD domains-containing protein 1"]
["ENSRNOG00000016581",261,21.95930512,107,6.883356886,3.190202903,1.673648185,1.71E-26,{"v":6.33e-26,"d":"6.33E-26"},"up","yes","Serpinb1a","protein_coding","chr17:31590677-31599102:+","gi|72255515|ref|NP_001026812.1|",1933,0,"leukocyte elastase inhibitor A [Rattus norvegicus]","gi|72255514|ref|NM_001031642.1|",1266,0,"Rattus norvegicus serine (or cysteine) proteinase inhibitor, clade B, member 1a (Serpinb1a), mRNA","Q4G075",746,0,"Leukocyte elastase inhibitor A","MA3388",197,{"v":9e-57,"d":"9.00E-57"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0006954|inflammatory response;GO:0010951|negative regulation of endopeptidase activity;GO:0019725|cellular homeostasis;GO:0032691|negative regulation of interleukin-1 beta production;GO:0042176|regulation of protein catabolic process;GO:0044342|type B pancreatic cell proliferation;GO:0045088|regulation of innate immune response;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005764|lysosome;GO:0005769|early endosome;GO:0036464|cytoplasmic ribonucleoprotein granule;","GO:0004867|serine-type endopeptidase inhibitor activity;GO:0030414|peptidase inhibitor activity;","K23425","SERPINB1; leukocyte elastase inhibitor"]
["ENSRNOG00000003748",96,8.07698579,6,0.385982629,20.92577536,4.387209175,{"v":3.62e-26,"d":"3.62E-26"},{"v":1.33e-25,"d":"1.33E-25"},"up","yes","ENSRNOG00000003748","protein_coding","chrX:50361248-50423269:+","gi|157818453|ref|NP_001102788.1|",1492,0,"uncharacterized protein CXorf21 homolog [Rattus norvegicus]","gi|157818452|ref|NM_001109318.1|",1558,0,"Rattus norvegicus similar to chromosome X open reading frame 21 (RGD1565785), mRNA",".",".",".",".",".",".",".",".","pfam15133","DUF4569","Domain of unknown function (DUF4569). This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. This family includes human protein CXorf21.","GO:0034157|positive regulation of toll-like receptor 7 signaling pathway;GO:0034161|positive regulation of toll-like receptor 8 signaling pathway;GO:0035751|regulation of lysosomal lumen pH;GO:0045089|positive regulation of innate immune response;","GO:0036020|endolysosome membrane;",".",".","."]
["ENSRNOG00000045679",248,20.86554662,99,6.36871338,3.276257759,1.712048865,{"v":5.02e-26,"d":"5.02E-26"},{"v":1.83e-25,"d":"1.83E-25"},"up","yes","Apoa1","protein_coding","chr8:46527144-46529035:+","gi|6978515|ref|NP_036870.1|",1264,{"v":1E-172,"d":"1.00E-172"},"apolipoprotein A-I preproprotein [Rattus norvegicus]","gi|298915444|emb|FQ210161.1|",888,0,"Rattus norvegicus TL0ABA33YH12 mRNA sequence","P04639",491,{"v":5e-174,"d":"5.00E-174"},"Apolipoprotein A-I",".",".",".",".","pfam01442","Apolipoprotein","Apolipoprotein A1/A4/E domain. These proteins contain several 22 residue repeats which form a pair of alpha helices. This family includes: Apolipoprotein A-I. Apolipoprotein A-IV, and Apolipoprotein E.","GO:0001932|regulation of protein phosphorylation;GO:0001935|endothelial cell proliferation;GO:0002719|negative regulation of cytokine production involved in immune response;GO:0006644|phospholipid metabolic process;GO:0006656|phosphatidylcholine biosynthetic process;GO:0006695|cholesterol biosynthetic process;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007229|integrin-mediated signaling pathway;GO:0007584|response to nutrient;GO:0008203|cholesterol metabolic process;GO:0008211|glucocorticoid metabolic process;GO:0009410|response to xenobiotic stimulus;GO:0010804|negative regulation of tumor necrosis factor-mediated signaling pathway;GO:0010873|positive regulation of cholesterol esterification;GO:0010875|positive regulation of cholesterol efflux;GO:0010898|positive regulation of triglyceride catabolic process;GO:0010903|negative regulation of very-low-density lipoprotein particle remodeling;GO:0014012|peripheral nervous system axon regeneration;GO:0015914|phospholipid transport;GO:0018158|protein oxidation;GO:0018206|peptidyl-methionine modification;GO:0019915|lipid storage;GO:0030300|regulation of intestinal cholesterol absorption;GO:0030301|cholesterol transport;GO:0030325|adrenal gland development;GO:0031100|animal organ regeneration;GO:0032489|regulation of Cdc42 protein signal transduction;GO:0032691|negative regulation of interleukin-1 beta production;GO:0033344|cholesterol efflux;GO:0033700|phospholipid efflux;GO:0034115|negative regulation of heterotypic cell-cell adhesion;GO:0034372|very-low-density lipoprotein particle remodeling;GO:0034375|high-density lipoprotein particle remodeling;GO:0034380|high-density lipoprotein particle assembly;GO:0035025|positive regulation of Rho protein signal transduction;GO:0042157|lipoprotein metabolic process;GO:0042158|lipoprotein biosynthetic process;GO:0042632|cholesterol homeostasis;GO:0043534|blood vessel endothelial cell migration;GO:0043627|response to estrogen;GO:0043691|reverse cholesterol transport;GO:0045723|positive regulation of fatty acid biosynthetic process;GO:0046470|phosphatidylcholine metabolic process;GO:0046889|positive regulation of lipid biosynthetic process;GO:0050728|negative regulation of inflammatory response;GO:0050766|positive regulation of phagocytosis;GO:0050821|protein stabilization;GO:0050919|negative chemotaxis;GO:0051006|positive regulation of lipoprotein lipase activity;GO:0051180|vitamin transport;GO:0051345|positive regulation of hydrolase activity;GO:0051346|negative regulation of hydrolase activity;GO:0051496|positive regulation of stress fiber assembly;GO:0055091|phospholipid homeostasis;GO:0060192|negative regulation of lipase activity;GO:0060354|negative regulation of cell adhesion molecule production;GO:0060761|negative regulation of response to cytokine stimulus;GO:0070328|triglyceride homeostasis;GO:0070508|cholesterol import;GO:0120009|intermembrane lipid transfer;GO:1900026|positive regulation of substrate adhesion-dependent cell spreading;GO:1902995|positive regulation of phospholipid efflux;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0009986|cell surface;GO:0030139|endocytic vesicle;GO:0031410|cytoplasmic vesicle;GO:0034361|very-low-density lipoprotein particle;GO:0034362|low-density lipoprotein particle;GO:0034363|intermediate-density lipoprotein particle;GO:0034364|high-density lipoprotein particle;GO:0034365|discoidal high-density lipoprotein particle;GO:0034366|spherical high-density lipoprotein particle;GO:0042627|chylomicron;","GO:0001540|amyloid-beta binding;GO:0005102|signaling receptor binding;GO:0005319|lipid transporter activity;GO:0005515|protein binding;GO:0005543|phospholipid binding;GO:0008035|high-density lipoprotein particle binding;GO:0008289|lipid binding;GO:0015485|cholesterol binding;GO:0019899|enzyme binding;GO:0031072|heat shock protein binding;GO:0031210|phosphatidylcholine binding;GO:0034190|apolipoprotein receptor binding;GO:0034191|apolipoprotein A-I receptor binding;GO:0042802|identical protein binding;GO:0045499|chemorepellent activity;GO:0055102|lipase inhibitor activity;GO:0060228|phosphatidylcholine-sterol O-acyltransferase activator activity;GO:0070653|high-density lipoprotein particle receptor binding;GO:0071813|lipoprotein particle binding;GO:0120020|intermembrane cholesterol transfer activity;","K08757","APOA1; apolipoprotein A-I"]
["ENSRNOG00000064497",119,10.01209697,17,1.093617449,9.155026721,3.194564097,{"v":5.19e-26,"d":"5.19E-26"},{"v":1.9e-25,"d":"1.90E-25"},"up","yes","Olr1585","protein_coding","chr13:86009008-86073347:+","gi|47576433|ref|NP_001001109.1|",1508,0,"olfactory receptor Olr1585 [Rattus norvegicus]","gi|672074948|ref|XM_008769791.1|",3320,0,"PREDICTED: Rattus norvegicus olfactory receptor 1587 (Olr1587), transcript variant X1, mRNA","P11369",222,{"v":2e-128,"d":"2.00E-128"},"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.",".",".",".",".","."]
["ENSRNOG00000007372",382,32.13967262,206,13.25207027,2.425256732,1.278137476,5.67E-26,{"v":2.07e-25,"d":"2.07E-25"},"up","yes","Casp1","protein_coding","chr8:2587831-2597383:+","gi|149030162|gb|EDL85233.1|",2144,0,"caspase 1, isoform CRA_b [Rattus norvegicus]","gi|31542340|ref|NM_012762.2|",1275,0,"Rattus norvegicus caspase 1 (Casp1), mRNA","P43527",828,0,"Caspase-1",".",".",".",".","pfam00656","Peptidase_C14","Caspase domain.","GO:0001666|response to hypoxia;GO:0001774|microglial cell activation;GO:0001819|positive regulation of cytokine production;GO:0006508|proteolysis;GO:0006915|apoptotic process;GO:0007494|midgut development;GO:0007520|myoblast fusion;GO:0007613|memory;GO:0009410|response to xenobiotic stimulus;GO:0009617|response to bacterium;GO:0009636|response to toxic substance;GO:0010506|regulation of autophagy;GO:0014070|response to organic cyclic compound;GO:0016485|protein processing;GO:0016540|protein autoprocessing;GO:0030324|lung development;GO:0032496|response to lipopolysaccharide;GO:0032730|positive regulation of interleukin-1 alpha production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0033198|response to ATP;GO:0042981|regulation of apoptotic process;GO:0043065|positive regulation of apoptotic process;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043280|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0046010|positive regulation of circadian sleep/wake cycle, non-REM sleep;GO:0050727|regulation of inflammatory response;GO:0050829|defense response to Gram-negative bacterium;GO:0051882|mitochondrial depolarization;GO:0060081|membrane hyperpolarization;GO:0070269|pyroptosis;GO:0071222|cellular response to lipopolysaccharide;GO:0071260|cellular response to mechanical stimulus;GO:0071310|cellular response to organic substance;GO:0071346|cellular response to interferon-gamma;GO:0097190|apoptotic signaling pathway;GO:0097300|programmed necrotic cell death;GO:1901998|toxin transport;GO:1903265|positive regulation of tumor necrosis factor-mediated signaling pathway;","GO:0005576|extracellular region;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005886|plasma membrane;GO:0032991|protein-containing complex;GO:0043005|neuron projection;GO:0072557|IPAF inflammasome complex;GO:0072558|NLRP1 inflammasome complex;GO:0072559|NLRP3 inflammasome complex;GO:0097169|AIM2 inflammasome complex;GO:0097179|protease inhibitor complex;","GO:0004175|endopeptidase activity;GO:0004197|cysteine-type endopeptidase activity;GO:0005515|protein binding;GO:0008233|peptidase activity;GO:0019900|kinase binding;GO:0042802|identical protein binding;GO:0050700|CARD domain binding;GO:0097110|scaffold protein binding;GO:0097199|cysteine-type endopeptidase activity involved in apoptotic signaling pathway;","K01370","CASP1; caspase 1 [EC:3.4.22.36]"]
["ENSRNOG00000002475",186,15.64915997,56,3.602504538,4.34396676,2.119013064,5.68E-26,{"v":2.07e-25,"d":"2.07E-25"},"up","yes","AABR07058831.1","protein_coding","chr7:128577102-128577620:-","gi|74198013|dbj|BAE35188.1|",785,{"v":4e-104,"d":"4.00E-104"},"unnamed protein product [Mus musculus]","gi|298915896|emb|FQ222827.1|",468,0,"Rattus norvegicus TL0ADA19YH23 mRNA sequence","P63029",305,{"v":4e-105,"d":"4.00E-105"},"Translationally-controlled tumor protein",".",".",".",".","pfam00838","TCTP","Translationally controlled tumor protein.",".",".",".",".","."]
["ENSRNOG00000021056",201,16.911189,66,4.24580892,3.983031106,1.993866747,{"v":5.95e-26,"d":"5.95E-26"},{"v":2.17e-25,"d":"2.17E-25"},"up","yes","Kcnj14","protein_coding","chr1:96293435-96495459:-","gi|24962814|ref|NP_733836.1|",2050,0,"ATP-sensitive inward rectifier potassium channel 14 [Rattus norvegicus]","gi|24962813|ref|NM_170718.1|",2736,0,"Rattus norvegicus potassium voltage-gated channel subfamily J member 14 (Kcnj14), mRNA","O70596",775,0,"ATP-sensitive inward rectifier potassium channel 14",".",".",".",".","pfam01007","IRK","Inward rectifier potassium channel.","GO:0034765|regulation of ion transmembrane transport;GO:1990573|potassium ion import across plasma membrane;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0043025|neuronal cell body;","GO:0005242|inward rectifier potassium channel activity;","K05007","KCNJ14, KIR2.4; potassium inwardly-rectifying channel subfamily J member 14"]
["ENSRNOG00000004409",178,14.97607782,51,3.280852347,4.564691194,2.190517264,6.49E-26,{"v":2.36e-25,"d":"2.36E-25"},"up","yes","Sash3","protein_coding","chrX:127326859-127341519:+","gi|564400662|ref|XP_006257592.1|",1589,0,"PREDICTED: SAM and SH3 domain-containing protein 3 isoform X1 [Rattus norvegicus]","gi|672088568|ref|XM_006257530.2|",2562,0,"PREDICTED: Rattus norvegicus SAM and SH3 domain containing 3 (Sash3), transcript variant X1, mRNA","Q8K352",592,0,"SAM and SH3 domain-containing protein 3",".",".",".",".","pfam12485","SLY","Lymphocyte signaling adaptor protein. This domain family is found in eukaryotes, and is typically between 144 and 156 amino acids in length. The family is found in association with pfam07647, pfam07653. There is a conserved LGKK sequence motif. SLY contains a Src homology 3 domain and a sterile alpha motif, suggesting that it functions as a signaling adaptor protein in lymphocytes.","GO:0002639|positive regulation of immunoglobulin production;GO:0002726|positive regulation of T cell cytokine production;GO:0002821|positive regulation of adaptive immune response;GO:0030890|positive regulation of B cell proliferation;GO:0032729|positive regulation of interferon-gamma production;GO:0032733|positive regulation of interleukin-10 production;GO:0032743|positive regulation of interleukin-2 production;GO:0032753|positive regulation of interleukin-4 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0042102|positive regulation of T cell proliferation;GO:0043372|positive regulation of CD4-positive, alpha-beta T cell differentiation;GO:0046622|positive regulation of organ growth;GO:0048873|homeostasis of number of cells within a tissue;GO:0051251|positive regulation of lymphocyte activation;","GO:0005634|nucleus;GO:0005737|cytoplasm;",".","K23706","SASH3; SAM and SH3 domain-containing protein 3"]
["ENSRNOG00000005348",393,33.06516058,216,13.89537465,2.379580358,1.250707175,7.71E-26,{"v":2.8e-25,"d":"2.80E-25"},"up","yes","Pamr1","protein_coding","chr3:88889046-88988606:+","gi|672046405|ref|XP_008760283.1|",3789,0,"PREDICTED: inactive serine protease PAMR1 isoform X1 [Rattus norvegicus]","gi|672046404|ref|XM_008762061.1|",2740,0,"PREDICTED: Rattus norvegicus peptidase domain containing associated with muscle regeneration 1 (Pamr1), transcript variant X1, mRNA","Q8BU25",1426,0,"Inactive serine protease PAMR1","VC1200",67.4,{"v":7e-11,"d":"7.00E-11"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;",".","GO:0004252|serine-type endopeptidase activity;GO:0005509|calcium ion binding;","K24362","PAMR1; inactive serine protease PAMR1"]
["ENSRNOG00000016688",437,36.7671124,255,16.40426174,2.241314665,1.164345207,1.14E-25,{"v":4.13e-25,"d":"4.13E-25"},"up","yes","Ston1","protein_coding","chr6:5843185-5892449:-","gi|281427176|ref|NP_891999.2|",3555,0,"stonin-1 [Rattus norvegicus]","gi|672055393|ref|XM_008764479.1|",2745,0,"PREDICTED: Rattus norvegicus stonin 1 (Ston1), transcript variant X1, mRNA","Q8CDJ8",1213,0,"Stonin-1",".",".",".",".","pfam00928","Adap_comp_sub","Adaptor complexes medium subunit family. This family also contains members which are coatomer subunits.","GO:0006897|endocytosis;GO:0006929|substrate-dependent cell migration;GO:0016192|vesicle-mediated transport;GO:0030100|regulation of endocytosis;GO:0048008|platelet-derived growth factor receptor signaling pathway;GO:0048041|focal adhesion assembly;GO:0048488|synaptic vesicle endocytosis;GO:0097178|ruffle assembly;GO:0120181|focal adhesion disassembly;","GO:0005905|clathrin-coated pit;GO:0008021|synaptic vesicle;GO:0030136|clathrin-coated vesicle;GO:0031252|cell leading edge;GO:0031410|cytoplasmic vesicle;GO:0042995|cell projection;","GO:0035615|clathrin adaptor activity;","K20067","STON1_2; stonin-1/2"]
["ENSRNOG00000046365",257,21.62276404,107,6.883356886,3.141310904,1.651366738,{"v":1.19e-25,"d":"1.19E-25"},{"v":4.3e-25,"d":"4.30E-25"},"up","yes","Oit3","protein_coding","chr20:27390113-27410692:-","gi|48040437|ref|NP_001001507.1|",2907,0,"oncoprotein-induced transcript 3 protein precursor [Rattus norvegicus]","gi|48040436|ref|NM_001001507.1|",2280,0,"Rattus norvegicus oncoprotein induced transcript 3 (Oit3), mRNA","Q6V0K7",1124,0,"Oncoprotein-induced transcript 3 protein",".",".",".",".","pfam00100","Zona_pellucida","Zona pellucida-like domain.","GO:1903118|urate homeostasis;","GO:0005615|extracellular space;GO:0005635|nuclear envelope;GO:0009986|cell surface;","GO:0005201|extracellular matrix structural constituent;GO:0005509|calcium ion binding;GO:0005515|protein binding;","K24431","OPA3; oncoprotein-induced transcript 3 protein"]
["ENSRNOG00000064682",198,16.65878319,65,4.181478482,3.983945694,1.994197982,{"v":1.35e-25,"d":"1.35E-25"},4.88E-25,"up","yes","ENSRNOG00000064682","lncRNA","chr13:82486637-82523851:+","gi|62659813|ref|XP_577285.1|",350,{"v":5e-34,"d":"5.00E-34"},"PREDICTED: SH2 domain-containing protein 1B isoform X2 [Rattus norvegicus]","gi|672027333|ref|XR_592058.1|",2293,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103692075 (LOC103692075), ncRNA","O35324",114,{"v":6e-27,"d":"6.00E-27"},"SH2 domain-containing protein 1B",".",".",".",".","pfam14868","DUF4487","Domain of unknown function (DUF4487). This family of proteins is found in eukaryotes. Proteins in this family are typically between 209 and 938 amino acids in length. There is a conserved WCF sequence motif. There is a single completely conserved residue W that may be functionally important.",".",".",".",".","."]
["ENSRNOG00000005093",495,41.64695798,308,19.81377496,2.1019194,1.071707349,1.88E-25,{"v":6.75e-25,"d":"6.75E-25"},"up","yes","Lgr6","protein_coding","chr13:46424383-46543945:-","gi|62659353|ref|XP_573455.1|",4381,0,"PREDICTED: leucine-rich repeat-containing G-protein coupled receptor 6 [Rattus norvegicus]","gi|672027121|ref|XM_001062538.5|",6295,0,"PREDICTED: Rattus norvegicus leucine-rich repeat-containing G protein-coupled receptor 6 (Lgr6), mRNA","Q3UVD5",1626,0,"Leucine-rich repeat-containing G-protein coupled receptor 6","alr0124_1",104,{"v":4e-22,"d":"4.00E-22"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0007411|axon guidance;GO:0030177|positive regulation of Wnt signaling pathway;GO:0030335|positive regulation of cell migration;GO:0042246|tissue regeneration;GO:0050919|negative chemotaxis;GO:1990523|bone regeneration;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0031982|vesicle;","GO:0004930|G protein-coupled receptor activity;GO:0008201|heparin binding;GO:0016500|protein-hormone receptor activity;GO:0048495|Roundabout binding;","K08399","LGR6; leucine-rich repeat-containing G protein-coupled receptor 6"]
["ENSRNOG00000022565",206,17.33186534,71,4.567461111,3.794638842,1.923962582,{"v":2.08e-25,"d":"2.08E-25"},{"v":7.44e-25,"d":"7.44E-25"},"up","yes","Lrrc25","protein_coding","chr16:18806890-18813671:-","gi|62662417|ref|XP_573882.1|",1630,0,"PREDICTED: leucine-rich repeat-containing protein 25 isoform X1 [Rattus norvegicus]","gi|672029252|ref|XM_001070537.5|",3599,0,"PREDICTED: Rattus norvegicus leucine rich repeat containing 25 (Lrrc25), transcript variant X1, mRNA","Q8K1T1",424,{"v":1E-134,"d":"1.00E-134"},"Leucine-rich repeat-containing protein 25",".",".",".",".","pfam00019","TGF_beta","Transforming growth factor beta like domain.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000010266",141,11.86307288,30,1.929913146,6.146946512,2.619869932,2.42E-25,{"v":8.65e-25,"d":"8.65E-25"},"up","yes","Cd180","protein_coding","chr2:33855991-33899936:+","gi|157823329|ref|NP_001099875.1|",3199,0,"CD180 antigen precursor [Rattus norvegicus]","gi|157823328|ref|NM_001106405.1|",2566,0,"Rattus norvegicus CD180 molecule (Cd180), mRNA","Q62192",1090,0,"CD180 antigen",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.","GO:0002224|toll-like receptor signaling pathway;GO:0002322|B cell proliferation involved in immune response;GO:0031666|positive regulation of lipopolysaccharide-mediated signaling pathway;GO:0071222|cellular response to lipopolysaccharide;","GO:0005615|extracellular space;GO:0016021|integral component of membrane;GO:0031012|extracellular matrix;","GO:0004888|transmembrane signaling receptor activity;","K06555","CD180; CD180 antigen"]
["ENSRNOG00000008736",130,10.93758492,24,1.543930516,7.084246867,2.824614487,{"v":2.66e-25,"d":"2.66E-25"},{"v":9.48e-25,"d":"9.48E-25"},"up","yes","Slamf8","protein_coding","chr13:85047727-85057211:-","gi|564381809|ref|XP_006250346.1|",1434,0,"PREDICTED: SLAM family member 8 isoform X1 [Rattus norvegicus]","gi|672074763|ref|XM_006250284.2|",2015,0,"PREDICTED: Rattus norvegicus SLAM family member 8 (Slamf8), transcript variant X1, mRNA","Q9D3G2",476,{"v":5e-163,"d":"5.00E-163"},"SLAM family member 8",".",".",".",".","pfam13927","Ig_3","Immunoglobulin domain. This family contains immunoglobulin-like domains.","GO:0002232|leukocyte chemotaxis involved in inflammatory response;GO:0002336|B-1 B cell lineage commitment;GO:0010760|negative regulation of macrophage chemotaxis;GO:0033860|regulation of NAD(P)H oxidase activity;GO:0042742|defense response to bacterium;GO:0043549|regulation of kinase activity;GO:0045577|regulation of B cell differentiation;GO:0060266|negative regulation of respiratory burst involved in inflammatory response;GO:0071466|cellular response to xenobiotic stimulus;GO:0090027|negative regulation of monocyte chemotaxis;GO:0090383|phagosome acidification;GO:1902623|negative regulation of neutrophil migration;GO:2000509|negative regulation of dendritic cell chemotaxis;","GO:0016021|integral component of membrane;","GO:0038023|signaling receptor activity;GO:0042802|identical protein binding;","K16853","SLAMF8, CD353; SLAM family member 8"]
["ENSRNOG00000033444",169,14.2188604,47,3.023530595,4.70273409,2.233499759,{"v":3.02e-25,"d":"3.02E-25"},{"v":1.08e-24,"d":"1.08E-24"},"up","yes","F10","protein_coding","chr16:76468838-76488141:-","gi|149057627|gb|EDM08870.1|",2594,0,"coagulation factor X [Rattus norvegicus]","gi|56961646|ref|NM_017143.2|",1566,0,"Rattus norvegicus coagulation factor X (F10), mRNA","Q63207",978,0,"Coagulation factor X","VC1649",118,{"v":1E-27,"d":"1.00E-27"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;GO:0007596|blood coagulation;GO:0051897|positive regulation of protein kinase B signaling;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005783|endoplasmic reticulum;GO:0016020|membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0003674|molecular_function;GO:0004252|serine-type endopeptidase activity;GO:0005509|calcium ion binding;GO:0005543|phospholipid binding;","K01314","F10; coagulation factor X [EC:3.4.21.6]"]
["ENSRNOG00000014312",106,8.918338477,12,0.771965258,11.55277181,3.530167129,3.07E-25,1.09E-24,"up","yes","AC109737.1","TR_C_gene","chr4:70417612-70418013:+","gi|68533982|gb|AAH99166.1|",697,{"v":8E-90,"d":"8.00E-90"},"Tcrb protein [Rattus norvegicus]","gi|207192|gb|M63795.1|RATTCBC3",390,0,"Rattus norvegicus T-cell receptor beta-chain (Tcrb) gene, exons 1 through 4 and partial cds","P01852",235,{"v":5e-78,"d":"5.00E-78"},"T-cell receptor beta-1 chain C region",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.",".",".",".",".","."]
["ENSRNOG00000008369",346,29.11080295,180,11.57947887,2.513999401,1.329984306,{"v":4.45e-25,"d":"4.45E-25"},1.57E-24,"up","yes","Gimap4","protein_coding","chr4:77636401-77643306:+","gi|76677905|ref|NP_775176.2|",1395,0,"GTPase IMAP family member 4 [Rattus norvegicus]","gi|76677904|ref|NM_173153.2|",1442,0,"Rattus norvegicus GTPase, IMAP family member 4 (Gimap4), mRNA","Q8K3K9",538,0,"GTPase IMAP family member 4","RSc1064",49.7,{"v":8e-06,"d":"8.00E-06"},"COG1159","pfam04548","AIG1","AIG1 family. Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.",".","GO:0005829|cytosol;","GO:0005525|GTP binding;",".","."]
["ENSRNOG00000065590",119,10.01209697,19,1.222278326,8.191339697,3.034099425,{"v":7e-25,"d":"7.00E-25"},2.47E-24,"up","yes","Gpr65","protein_coding","chr6:117515648-117536512:+","gi|157822703|ref|NP_001100221.1|",1678,0,"psychosine receptor [Rattus norvegicus]","gi|672056501|ref|XM_008764761.1|",1584,0,"PREDICTED: Rattus norvegicus G-protein coupled receptor 65 (Gpr65), transcript variant X1, mRNA","Q61038",593,0,"Psychosine receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.",".",".",".",".","."]
["ENSRNOG00000016826",132,11.10585546,26,1.672591393,6.63990949,2.731163576,{"v":7.67e-25,"d":"7.67E-25"},{"v":2.7e-24,"d":"2.70E-24"},"up","yes","Pla2g2d","protein_coding","chr5:151018870-151022525:+","gi|149024390|gb|EDL80887.1|",994,{"v":4e-128,"d":"4.00E-128"},"phospholipase A2, group IID [Rattus norvegicus]","gi|61740622|ref|NM_001013428.1|",1830,0,"Rattus norvegicus phospholipase A2, group IID (Pla2g2d), mRNA","Q9WVF6",261,{"v":6e-82,"d":"6.00E-82"},"Group IID secretory phospholipase A2",".",".",".",".","pfam00068","Phospholip_A2_1","Phospholipase A2. Phospholipase A2 releases fatty acids from the second carbon group of glycerol. Perhaps the best known members are secreted snake venoms, but also found in secreted pancreatic and membrane-associated forms. Structure is all-alpha, with two core disulfide-linked helices and a calcium-binding loop. This alignment represents the major family of PLA2s. A second minor family, defined by the honeybee venom PLA2 PDB:1POC and related sequences from Gila monsters (Heloderma), is not recognized. This minor family conserves the core helix pair but is substantially different elsewhere. The PROSITE pattern PA2_HIS, specific to the first core helix, recognizes both families.","GO:0002361|CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0002864|regulation of acute inflammatory response to antigenic stimulus;GO:0006644|phospholipid metabolic process;GO:0016042|lipid catabolic process;GO:0042130|negative regulation of T cell proliferation;GO:0046337|phosphatidylethanolamine metabolic process;GO:0046470|phosphatidylcholine metabolic process;GO:0046471|phosphatidylglycerol metabolic process;GO:0050482|arachidonic acid secretion;GO:0050868|negative regulation of T cell activation;","GO:0005576|extracellular region;","GO:0004623|phospholipase A2 activity;GO:0005509|calcium ion binding;GO:0005543|phospholipid binding;GO:0008201|heparin binding;GO:0043395|heparan sulfate proteoglycan binding;GO:0047498|calcium-dependent phospholipase A2 activity;","K01047","PLA2G, SPLA2; secretory phospholipase A2 [EC:3.1.1.4]"]
["ENSRNOG00000016069",100,8.413526865,10,0.643304382,13.0786096,3.70913727,{"v":9.71e-25,"d":"9.71E-25"},{"v":3.41e-24,"d":"3.41E-24"},"up","yes","Cd3e","protein_coding","chr8:45303852-45315022:-","gi|672061635|ref|XP_008764383.1|",818,{"v":2E-99,"d":"2.00E-99"},"PREDICTED: T-cell surface glycoprotein CD3 epsilon chain isoform X1 [Rattus norvegicus]","gi|672061634|ref|XM_008766161.1|",1103,0,"PREDICTED: Rattus norvegicus CD3 molecule, epsilon (Cd3e), transcript variant X1, mRNA","P22646",247,{"v":4e-74,"d":"4.00E-74"},"T-cell surface glycoprotein CD3 epsilon chain",".",".",".",".","pfam02189","ITAM","Immunoreceptor tyrosine-based activation motif.","GO:0001954|positive regulation of cell-matrix adhesion;GO:0002250|adaptive immune response;GO:0002669|positive regulation of T cell anergy;GO:0007166|cell surface receptor signaling pathway;GO:0007584|response to nutrient;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0016358|dendrite development;GO:0021549|cerebellum development;GO:0031295|T cell costimulation;GO:0032729|positive regulation of interferon-gamma production;GO:0032743|positive regulation of interleukin-2 production;GO:0032753|positive regulation of interleukin-4 production;GO:0033077|T cell differentiation in thymus;GO:0033634|positive regulation of cell-cell adhesion mediated by integrin;GO:0042102|positive regulation of T cell proliferation;GO:0045059|positive thymic T cell selection;GO:0045060|negative thymic T cell selection;GO:0045879|negative regulation of smoothened signaling pathway;GO:0046641|positive regulation of alpha-beta T cell proliferation;GO:0046649|lymphocyte activation;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050850|positive regulation of calcium-mediated signaling;GO:0050852|T cell receptor signaling pathway;GO:0050870|positive regulation of T cell activation;GO:0097190|apoptotic signaling pathway;","GO:0001772|immunological synapse;GO:0005575|cellular_component;GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0042101|T cell receptor complex;GO:0042105|alpha-beta T cell receptor complex;GO:0043197|dendritic spine;GO:0044297|cell body;","GO:0003674|molecular_function;GO:0004888|transmembrane signaling receptor activity;GO:0017124|SH3 domain binding;GO:0042802|identical protein binding;GO:0046982|protein heterodimerization activity;","K06451","CD3E; T-cell surface glycoprotein CD3 epsilon chain"]
["ENSRNOG00000065968",85,7.151497835,3,0.192991315,37.05606054,5.21163761,{"v":1.14e-24,"d":"1.14E-24"},{"v":4e-24,"d":"4.00E-24"},"up","yes","Rn7sl1","misc_RNA","chr6:87636804-87637103:+","gi|594691438|ref|XP_007193055.1|",518,{"v":5e-63,"d":"5.00E-63"},"PREDICTED: uncharacterized protein LOC103017900 [Balaenoptera acutorostrata scammoni]","gi|527047032|tpe|HG323686.1|",300,{"v":1e-154,"d":"1.00E-154"},"TPA: Mus musculus SRP RNA for signal recognition particle RNA",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSRNOG00000019907",359,30.20456144,193,12.41577457,2.432756915,1.282592171,1.25E-24,{"v":4.35e-24,"d":"4.35E-24"},"up","yes","Nfkbie","protein_coding","chr9:15436941-15450437:-","gi|40018590|ref|NP_954542.1|",1617,0,"NF-kappa-B inhibitor epsilon [Rattus norvegicus]","gi|84578882|dbj|AB197928.1|",1604,0,"Rattus norvegicus dsm-1 mRNA for D-serine modulator-1, complete cds","O54910",597,0,"NF-kappa-B inhibitor epsilon","SPAC926.04c",140,{"v":2E-46,"d":"2.00E-46"},"COG0326","pfam08449","UAA","UAA transporter family. This family includes transporters with a specificity for UDP-N-acetylglucosamine.","GO:0042942|D-serine transport;","GO:0001650|fibrillar center;GO:0005654|nucleoplasm;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0048471|perinuclear region of cytoplasm;","GO:0003674|molecular_function;","K05872","NFKBIE; NF-kappa-B inhibitor epsilon"]
["ENSRNOG00000009385",220,18.5097591,84,5.403756808,3.425350134,1.776251465,2.06E-24,{"v":7.14e-24,"d":"7.14E-24"},"up","yes","Pik3cg","protein_coding","chr6:48766864-48802043:-","gi|392348758|ref|XP_003750188.1|",5918,0,"PREDICTED: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X2 [Rattus norvegicus]","gi|672055966|ref|XM_006240005.2|",6572,0,"PREDICTED: Rattus norvegicus phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma (Pik3cg), transcript variant X5, mRNA","Q9JHG7",2245,0,"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform","SPAC458.05",227,{"v":3e-60,"d":"3.00E-60"},"COG5032","pfam00613","PI3Ka","Phosphoinositide 3-kinase family, accessory domain (PIK domain). PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation.","GO:0001932|regulation of protein phosphorylation;GO:0002675|positive regulation of acute inflammatory response;GO:0003376|sphingosine-1-phosphate receptor signaling pathway;GO:0006468|protein phosphorylation;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0010595|positive regulation of endothelial cell migration;GO:0010897|negative regulation of triglyceride catabolic process;GO:0014065|phosphatidylinositol 3-kinase signaling;GO:0016310|phosphorylation;GO:0016477|cell migration;GO:0032252|secretory granule localization;GO:0035022|positive regulation of Rac protein signal transduction;GO:0036092|phosphatidylinositol-3-phosphate biosynthetic process;GO:0043085|positive regulation of catalytic activity;GO:0043406|positive regulation of MAP kinase activity;GO:0046854|phosphatidylinositol phosphorylation;GO:0048015|phosphatidylinositol-mediated signaling;GO:0051897|positive regulation of protein kinase B signaling;GO:0071320|cellular response to cAMP;GO:0097284|hepatocyte apoptotic process;GO:1903169|regulation of calcium ion transmembrane transport;GO:2000270|negative regulation of fibroblast apoptotic process;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005942|phosphatidylinositol 3-kinase complex;GO:0005943|phosphatidylinositol 3-kinase complex, class IA;GO:0005944|phosphatidylinositol 3-kinase complex, class IB;GO:0016020|membrane;","GO:0005524|ATP binding;GO:0016301|kinase activity;GO:0016303|1-phosphatidylinositol-3-kinase activity;GO:0035005|1-phosphatidylinositol-4-phosphate 3-kinase activity;GO:0042802|identical protein binding;GO:0046875|ephrin receptor binding;GO:0046934|phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0052742|phosphatidylinositol kinase activity;GO:0052812|phosphatidylinositol-3,4-bisphosphate 5-kinase activity;","K21289","PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [EC:2.7.1.153]"]
["ENSRNOG00000025297",187,15.73329524,61,3.924156729,4.009344255,2.003366297,{"v":2.12e-24,"d":"2.12E-24"},{"v":7.36e-24,"d":"7.36E-24"},"up","yes","Gpr171","protein_coding","chr2:143359564-143366698:-","gi|157824140|ref|NP_001102980.1|",1639,0,"probable G-protein coupled receptor 171 [Rattus norvegicus]","gi|157824139|ref|NM_001109510.1|",1640,0,"Rattus norvegicus G protein-coupled receptor 171 (Gpr171), mRNA","Q8BG55",585,0,"Probable G-protein coupled receptor 171",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0035589|G protein-coupled purinergic nucleotide receptor signaling pathway;GO:0045638|negative regulation of myeloid cell differentiation;","GO:0016021|integral component of membrane;","GO:0045028|G protein-coupled purinergic nucleotide receptor activity;","K08441","GPR171; G protein-coupled receptor 171"]
["ENSRNOG00000019179",430,36.17816552,256,16.46859218,2.196797706,1.135402024,{"v":2.38e-24,"d":"2.38E-24"},{"v":8.24e-24,"d":"8.24E-24"},"up","yes","Ggta1","protein_coding","chr3:18732991-18809908:-","gi|149038922|gb|EDL93142.1|",2021,0,"glycoprotein galactosyltransferase alpha 1, 3, isoform CRA_b [Rattus norvegicus]","gi|672045123|ref|XM_008761702.1|",2826,0,"PREDICTED: Rattus norvegicus glycoprotein, alpha-galactosyltransferase 1,3 (Ggta1p), transcript variant X5, mRNA","Q3L7M0",692,0,"N-acetyllactosaminide alpha-1,3-galactosyltransferase",".",".",".",".","pfam03414","Glyco_transf_6","Glycosyltransferase family 6.","GO:0005975|carbohydrate metabolic process;GO:0033580|protein galactosylation at cell surface;","GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;GO:0031982|vesicle;GO:0031985|Golgi cisterna;GO:0032580|Golgi cisterna membrane;","GO:0016757|transferase activity, transferring glycosyl groups;GO:0016758|transferase activity, transferring hexosyl groups;GO:0046872|metal ion binding;GO:0047276|N-acetyllactosaminide 3-alpha-galactosyltransferase activity;","K00743","GGTA1; N-acetyllactosaminide 3-alpha-galactosyltransferase [EC:2.4.1.87]"]
["ENSRNOG00000069630",445,37.44019455,270,17.36921831,2.155548619,1.108055104,{"v":3.09e-24,"d":"3.09E-24"},{"v":1.06e-23,"d":"1.06E-23"},"up","yes","Rsl1d1","protein_coding","chr10:4397821-4439593:+","gi|672066617|ref|XP_008765724.1|",1973,0,"PREDICTED: ribosomal L1 domain-containing protein 1 [Rattus norvegicus]","gi|672066616|ref|XM_008767502.1|",1960,0,"PREDICTED: Rattus norvegicus ribosomal L1 domain containing 1 (Rsl1d1), mRNA","Q8BVY0",638,0,"Ribosomal L1 domain-containing protein 1",".",".",".",".","pfam00687","Ribosomal_L1","Ribosomal protein L1p/L10e family. This family includes prokaryotic L1 and eukaryotic L10.",".",".",".",".","."]
["ENSRNOG00000009390",83,6.983227298,3,0.192991315,36.18415323,5.177286105,{"v":4.26e-24,"d":"4.26E-24"},{"v":1.46e-23,"d":"1.46E-23"},"up","yes","Edn2","protein_coding","chr5:133751217-133756814:+","gi|6978793|ref|NP_036681.1|",881,{"v":8e-115,"d":"8.00E-115"},"endothelin-2 precursor [Rattus norvegicus]","gi|985567537|ref|NM_007902.3|",844,0,"Mus musculus endothelin 2 (Edn2), mRNA","P23943",328,{"v":2e-110,"d":"2.00E-110"},"Endothelin-2",".",".",".",".","pfam00322","Endothelin","Endothelin family.","GO:0001516|prostaglandin biosynthetic process;GO:0001525|angiogenesis;GO:0001543|ovarian follicle rupture;GO:0001659|temperature homeostasis;GO:0001944|vasculature development;GO:0002690|positive regulation of leukocyte chemotaxis;GO:0003100|regulation of systemic arterial blood pressure by endothelin;GO:0006874|cellular calcium ion homeostasis;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007205|protein kinase C-activating G protein-coupled receptor signaling pathway;GO:0008284|positive regulation of cell proliferation;GO:0009932|cell tip growth;GO:0010460|positive regulation of heart rate;GO:0014824|artery smooth muscle contraction;GO:0014826|vein smooth muscle contraction;GO:0019221|cytokine-mediated signaling pathway;GO:0019229|regulation of vasoconstriction;GO:0019722|calcium-mediated signaling;GO:0030593|neutrophil chemotaxis;GO:0031175|neuron projection development;GO:0042116|macrophage activation;GO:0042310|vasoconstriction;GO:0043542|endothelial cell migration;GO:0045987|positive regulation of smooth muscle contraction;GO:0046887|positive regulation of hormone secretion;GO:0046888|negative regulation of hormone secretion;GO:0048016|inositol phosphate-mediated signaling;GO:0048246|macrophage chemotaxis;GO:0048286|lung alveolus development;GO:0048675|axon extension;GO:0060585|positive regulation of prostaglandin-endoperoxide synthase activity;GO:0097009|energy homeostasis;","GO:0005615|extracellular space;","GO:0005179|hormone activity;GO:0031708|endothelin B receptor binding;","K16367","EDN2; endothelin-2"]
["ENSRNOG00000017488",288,24.23095737,138,8.87760047,2.72944896,1.448609719,{"v":7.49e-24,"d":"7.49E-24"},{"v":2.55e-23,"d":"2.55E-23"},"up","yes","Snx24","protein_coding","chr18:46671443-46826068:+","gi|672083495|ref|XP_008770374.1|",1255,{"v":3e-163,"d":"3.00E-163"},"PREDICTED: sorting nexin-24 isoform X2 [Rattus norvegicus]","gi|672083494|ref|XM_008772152.1|",2236,0,"PREDICTED: Rattus norvegicus sorting nexin 24 (Snx24), transcript variant X2, mRNA","Q5U2S5",309,{"v":4e-98,"d":"4.00E-98"},"Sorting nexin-24",".",".",".",".","pfam00787","PX","PX domain. PX domains bind to phosphoinositides.","GO:0015031|protein transport;","GO:0030659|cytoplasmic vesicle membrane;","GO:0010314|phosphatidylinositol-5-phosphate binding;GO:0032266|phosphatidylinositol-3-phosphate binding;GO:0070273|phosphatidylinositol-4-phosphate binding;GO:1901981|phosphatidylinositol phosphate binding;","K17941","SNX22_24; sorting nexin-22/24"]
["ENSRNOG00000057443",446,37.52432982,274,17.62654006,2.128853972,1.090076992,1.08E-23,{"v":3.62e-23,"d":"3.62E-23"},"up","yes","Nos2","protein_coding","chr10:63815308-63851210:+","gi|564373342|ref|XP_006247011.1|",6175,0,"PREDICTED: nitric oxide synthase, inducible-like [Rattus norvegicus]","gi|430718|gb|U03699.1|RNU03699",3784,0,"Rattus norvegicus Sprague Dawley inducible nitric oxide synthase (NOS) mRNA, complete cds","Q06518",2306,0,"Nitric oxide synthase, inducible","BH0823",346,{"v":1e-106,"d":"1.00E-106"},"COG4362","pfam02898","NO_synthase","Nitric oxide synthase, oxygenase domain.","GO:0001666|response to hypoxia;GO:0001935|endothelial cell proliferation;GO:0001974|blood vessel remodeling;GO:0006527|arginine catabolic process;GO:0006801|superoxide metabolic process;GO:0006809|nitric oxide biosynthetic process;GO:0006954|inflammatory response;GO:0007165|signal transduction;GO:0007199|G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger;GO:0007263|nitric oxide mediated signal transduction;GO:0007568|aging;GO:0007623|circadian rhythm;GO:0008016|regulation of heart contraction;GO:0008217|regulation of blood pressure;GO:0009612|response to mechanical stimulus;GO:0009617|response to bacterium;GO:0009725|response to hormone;GO:0010629|negative regulation of gene expression;GO:0014823|response to activity;GO:0016137|glycoside metabolic process;GO:0018119|peptidyl-cysteine S-nitrosylation;GO:0019934|cGMP-mediated signaling;GO:0031284|positive regulation of guanylate cyclase activity;GO:0032310|prostaglandin secretion;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0034612|response to tumor necrosis factor;GO:0035556|intracellular signal transduction;GO:0035902|response to immobilization stress;GO:0042060|wound healing;GO:0042127|regulation of cell proliferation;GO:0042177|negative regulation of protein catabolic process;GO:0042742|defense response to bacterium;GO:0043065|positive regulation of apoptotic process;GO:0045776|negative regulation of blood pressure;GO:0048384|retinoic acid receptor signaling pathway;GO:0050796|regulation of insulin secretion;GO:0050829|defense response to Gram-negative bacterium;GO:0051712|positive regulation of killing of cells of other organism;GO:0071222|cellular response to lipopolysaccharide;GO:0071285|cellular response to lithium ion;GO:0071305|cellular response to vitamin D;GO:0071345|cellular response to cytokine stimulus;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071407|cellular response to organic cyclic compound;GO:0071461|cellular response to redox state;GO:0071466|cellular response to xenobiotic stimulus;GO:0071548|response to dexamethasone;GO:1900015|regulation of cytokine production involved in inflammatory response;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005777|peroxisome;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0012506|vesicle membrane;GO:0030863|cortical cytoskeleton;GO:0048471|perinuclear region of cytoplasm;","GO:0003779|actin binding;GO:0004517|nitric-oxide synthase activity;GO:0005515|protein binding;GO:0005516|calmodulin binding;GO:0008013|beta-catenin binding;GO:0008603|cAMP-dependent protein kinase regulator activity;GO:0010181|FMN binding;GO:0016491|oxidoreductase activity;GO:0019901|protein kinase binding;GO:0020037|heme binding;GO:0034617|tetrahydrobiopterin binding;GO:0034618|arginine binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0045296|cadherin binding;GO:0046872|metal ion binding;GO:0050660|flavin adenine dinucleotide binding;GO:0050661|NADP binding;GO:0050998|nitric-oxide synthase binding;GO:0051879|Hsp90 protein binding;","K13241","NOS2; nitric-oxide synthase, inducible [EC:1.14.13.39]"]
["ENSRNOG00000062707",80,6.730821492,2,0.128660876,52.3144384,5.70913727,1.57E-23,{"v":5.27e-23,"d":"5.27E-23"},"up","yes","ENSRNOG00000062707","lncRNA","chr2:51977201-51983724:-",".",".",".",".","gi|672041660|ref|XR_590924.1|",538,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102556643 (LOC102556643), transcript variant X4, ncRNA",".",".",".",".",".",".",".",".","pfam07793","DUF1631","Protein of unknown function (DUF1631). The members of this family are sequences derived from a group of hypothetical proteins expressed by certain bacterial species. The region concerned is approximately 440 amino acid residues in length.",".",".",".",".","."]
["ENSRNOG00000056714",134,11.274126,30,1.929913146,5.841778955,2.54640777,1.82E-23,{"v":6.05e-23,"d":"6.05E-23"},"up","yes","Sla","protein_coding","chr7:98535368-98584648:-","gi|149066283|gb|EDM16156.1|",1573,0,"src-like adaptor, isoform CRA_b [Rattus norvegicus]","gi|31342521|ref|NM_178097.2|",1624,0,"Rattus norvegicus src-like adaptor (Sla), mRNA","P59622",601,0,"Src-like-adapter",".",".",".",".","pfam00017","SH2","SH2 domain.","GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0009966|regulation of signal transduction;GO:0030154|cell differentiation;GO:0045087|innate immune response;","GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005925|focal adhesion;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0043197|dendritic spine;","GO:0005102|signaling receptor binding;","K23698","SLA; src-like-adapter"]
["ENSRNOG00000061403",338,28.4377208,181,11.64380931,2.442303892,1.288242724,1.96E-23,{"v":6.53e-23,"d":"6.53E-23"},"up","yes","AABR07039446.2","protein_coding","chrX:71220367-71242376:+","gi|564322995|ref|XP_006227480.1|",4726,0,"PREDICTED: toll-like receptor 13 [Rattus norvegicus]","gi|672032506|ref|XM_006227419.2|",3814,0,"PREDICTED: Rattus norvegicus toll-like receptor 13 (Tlr13), transcript variant X2, mRNA","Q6R5N8",1672,0,"Toll-like receptor 13","SPBC19C7.03_1",61.2,{"v":2E-8,"d":"2.00E-08"},"COG4886","pfam01582","TIR","TIR domain. The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.",".",".",".",".","."]
["ENSRNOG00000032708",281,23.64201049,135,8.684609155,2.722288369,1.444819898,{"v":3.16e-23,"d":"3.16E-23"},1.04E-22,"up","yes","RT1-Bb","protein_coding","chr20:4596559-4607597:-","gi|46237565|emb|CAE83945.1|",1143,{"v":1e-140,"d":"1.00E-140"},"RT1 class II, B beta [Rattus norvegicus]","gi|89214481|gb|AC120734.5|",4049,0,"Rattus norvegicus BAC CH230-220D1 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P29826",418,{"v":2E-132,"d":"2.00E-132"},"Rano class II histocompatibility antigen, B-1 beta chain",".",".",".",".","pfam00969","MHC_II_beta","Class II histocompatibility antigen, beta domain.","GO:0002250|adaptive immune response;GO:0002344|B cell affinity maturation;GO:0002381|immunoglobulin production involved in immunoglobulin mediated immune response;GO:0002503|peptide antigen assembly with MHC class II protein complex;GO:0002504|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;GO:0002579|positive regulation of antigen processing and presentation;GO:0002827|positive regulation of T-helper 1 type immune response;GO:0006955|immune response;GO:0006959|humoral immune response;GO:0019882|antigen processing and presentation;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0042130|negative regulation of T cell proliferation;GO:0046635|positive regulation of alpha-beta T cell activation;GO:0048002|antigen processing and presentation of peptide antigen;GO:0050832|defense response to fungus;GO:0050852|T cell receptor signaling pathway;GO:0050870|positive regulation of T cell activation;GO:0071315|cellular response to morphine;GO:0071346|cellular response to interferon-gamma;GO:0071385|cellular response to glucocorticoid stimulus;GO:0071549|cellular response to dexamethasone stimulus;","GO:0005769|early endosome;GO:0005771|multivesicular body;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0042613|MHC class II protein complex;","GO:0015643|toxic substance binding;GO:0023026|MHC class II protein complex binding;GO:0031625|ubiquitin protein ligase binding;GO:0042605|peptide antigen binding;GO:0044877|protein-containing complex binding;GO:1990405|protein antigen binding;","K06752","MHC2; MHC class II antigen"]
["ENSRNOG00000049422",213,17.92081222,83,5.339426369,3.356317885,1.746879364,{"v":3.5e-23,"d":"3.50E-23"},{"v":1.15e-22,"d":"1.15E-22"},"up","yes","Fcgr2a","protein_coding","chr13:83280784-83295967:-","gi|31542804|ref|NP_446295.2|",1383,0,"low affinity immunoglobulin gamma Fc region receptor III [Rattus norvegicus]","gi|672074740|ref|XM_006250303.2|",1593,0,"PREDICTED: Rattus norvegicus Fc fragment of IgG, low affinity IIa, receptor (Fcgr2a), transcript variant X1, mRNA","P27645",473,{"v":7e-164,"d":"7.00E-164"},"Low affinity immunoglobulin gamma Fc region receptor III",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0001788|antibody-dependent cellular cytotoxicity;GO:0001798|positive regulation of type IIa hypersensitivity;GO:0001805|positive regulation of type III hypersensitivity;GO:0001812|positive regulation of type I hypersensitivity;GO:0001813|regulation of antibody-dependent cellular cytotoxicity;GO:0001820|serotonin secretion;GO:0006910|phagocytosis, recognition;GO:0006911|phagocytosis, engulfment;GO:0007166|cell surface receptor signaling pathway;GO:0021675|nerve development;GO:0030593|neutrophil chemotaxis;GO:0032680|regulation of tumor necrosis factor production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0038094|Fc-gamma receptor signaling pathway;GO:0042590|antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:0045576|mast cell activation;GO:0050766|positive regulation of phagocytosis;GO:0050776|regulation of immune response;GO:1905449|regulation of Fc-gamma receptor signaling pathway involved in phagocytosis;","GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0004888|transmembrane signaling receptor activity;GO:0019770|IgG receptor activity;GO:0019864|IgG binding;GO:0034987|immunoglobulin receptor binding;","K06463","FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III"]
["ENSRNOG00000017020",390,32.81275477,228,14.66733991,2.23713059,1.161649474,{"v":5.28e-23,"d":"5.28E-23"},{"v":1.71e-22,"d":"1.71E-22"},"up","yes","Inpp5d","protein_coding","chr9:88287677-88392746:+","gi|9506813|ref|NP_062184.1|",5734,0,"phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 [Rattus norvegicus]","gi|9506812|ref|NM_019311.1|",4859,0,"Rattus norvegicus inositol polyphosphate-5-phosphatase D (Inpp5d), mRNA","P97573",2197,0,"Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1","YNL106c_2",131,{"v":2e-30,"d":"2.00E-30"},"COG5411","pfam00017","SH2","SH2 domain.","GO:0006915|apoptotic process;GO:0008150|biological_process;GO:0008285|negative regulation of cell proliferation;GO:0008340|determination of adult lifespan;GO:0009968|negative regulation of signal transduction;GO:0016064|immunoglobulin mediated immune response;GO:0030853|negative regulation of granulocyte differentiation;GO:0030889|negative regulation of B cell proliferation;GO:0032715|negative regulation of interleukin-6 production;GO:0035556|intracellular signal transduction;GO:0043065|positive regulation of apoptotic process;GO:0045579|positive regulation of B cell differentiation;GO:0045621|positive regulation of lymphocyte differentiation;GO:0045648|positive regulation of erythrocyte differentiation;GO:0045656|negative regulation of monocyte differentiation;GO:0045659|negative regulation of neutrophil differentiation;GO:0045671|negative regulation of osteoclast differentiation;GO:0045779|negative regulation of bone resorption;GO:0046856|phosphatidylinositol dephosphorylation;GO:0050777|negative regulation of immune response;GO:0050869|negative regulation of B cell activation;","GO:0005829|cytosol;GO:0005856|cytoskeleton;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0030863|cortical cytoskeleton;GO:0045121|membrane raft;","GO:0004439|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0004445|inositol-polyphosphate 5-phosphatase activity;GO:0005515|protein binding;GO:0016791|phosphatase activity;GO:0017124|SH3 domain binding;GO:0030487|inositol-4,5-bisphosphate 5-phosphatase activity;GO:0034485|phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity;GO:0034594|phosphatidylinositol trisphosphate phosphatase activity;GO:0051425|PTB domain binding;GO:0052658|inositol-1,4,5-trisphosphate 5-phosphatase activity;GO:0052659|inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity;","K03084","SHIP1, INPP5D; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 [EC:3.1.3.86]"]
["ENSRNOG00000030530",94,7.908715253,10,0.643304382,12.29389302,3.619869932,5.72E-23,1.85E-22,"up","yes","Gzmm","protein_coding","chr7:10011066-10016665:-","gi|158262012|ref|NP_476531.1|",1345,0,"granzyme M precursor [Rattus norvegicus]","gi|298885451|emb|FQ233430.1|",955,0,"Rattus norvegicus TL0AEA61YO04 mRNA sequence","Q03238",511,0,"Granzyme M (Fragment)","VC1200",75.5,{"v":2E-14,"d":"2.00E-14"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0001913|T cell mediated cytotoxicity;GO:0006508|proteolysis;GO:0006915|apoptotic process;GO:0008150|biological_process;GO:0008219|cell death;GO:0019835|cytolysis;GO:0045087|innate immune response;","GO:0005575|cellular_component;GO:0005576|extracellular region;","GO:0004175|endopeptidase activity;GO:0004252|serine-type endopeptidase activity;GO:0008236|serine-type peptidase activity;","K08649","GZMM; granzyme M [EC:3.4.21.-]"]
["ENSRNOG00000014202",186,15.64915997,65,4.181478482,3.74249444,1.904000173,{"v":8.4e-23,"d":"8.40E-23"},{"v":2.7e-22,"d":"2.70E-22"},"up","yes","Snx20","protein_coding","chr19:18435935-18445107:+","gi|672084453|ref|XP_008770624.1|",1456,0,"PREDICTED: sorting nexin-20 isoform X1 [Rattus norvegicus]","gi|68163432|ref|NM_001024999.1|",1368,0,"Rattus norvegicus sorting nexin 20 (Snx20), mRNA","Q5BK61",556,0,"Sorting nexin-20",".",".",".",".","pfam00787","PX","PX domain. PX domains bind to phosphoinositides.","GO:0015031|protein transport;","GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0031901|early endosome membrane;","GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0032266|phosphatidylinositol-3-phosphate binding;GO:1901981|phosphatidylinositol phosphate binding;","K17931","SNX20; sorting nexin-20"]
["ENSRNOG00000069681",111,9.33901482,19,1.222278326,7.640661398,2.933697528,1.27E-22,{"v":4.04e-22,"d":"4.04E-22"},"up","yes","ENSRNOG00000069681","pseudogene","chr4:31200445-31205142:-","gi|672018004|ref|XP_008773887.1|",7451,0,"PREDICTED: LOW QUALITY PROTEIN: sterile alpha motif domain-containing protein 9-like [Rattus norvegicus]","gi|672018003|ref|XM_008775665.1|",1495,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102553788 (LOC102553788), transcript variant X1, mRNA","Q69Z37",2424,0,"Sterile alpha motif domain-containing protein 9-like",".",".",".",".","pfam00536","SAM_1","SAM domain (Sterile alpha motif). It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.",".",".",".",".","."]
["ENSRNOG00000019859",424,35.67335391,261,16.79024437,2.12464769,1.087223633,1.62E-22,5.17E-22,"up","yes","Pla2g15","protein_coding","chr19:34050694-34068063:+","gi|51948522|ref|NP_001004277.1|",2062,0,"group XV phospholipase A2 precursor [Rattus norvegicus]","gi|71534293|ref|NM_001004277.2|",2640,0,"Rattus norvegicus phospholipase A2, group XV (Pla2g15), mRNA","Q675A5",798,0,"Group XV phospholipase A2",".",".",".",".","pfam02450","LCAT","Lecithin:cholesterol acyltransferase. Lecithin:cholesterol acyltransferase (LCAT) is involved in extracellular metabolizm of plasma lipoproteins, including cholesterol.","GO:0006629|lipid metabolic process;GO:0006631|fatty acid metabolic process;GO:0006650|glycerophospholipid metabolic process;GO:0006651|diacylglycerol biosynthetic process;GO:0006658|phosphatidylserine metabolic process;GO:0006672|ceramide metabolic process;GO:0034638|phosphatidylcholine catabolic process;GO:0046338|phosphatidylethanolamine catabolic process;GO:0046470|phosphatidylcholine metabolic process;GO:0046471|phosphatidylglycerol metabolic process;","GO:0005615|extracellular space;GO:0005654|nucleoplasm;GO:0005764|lysosome;GO:0016020|membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0004623|phospholipase A2 activity;GO:0008270|zinc ion binding;GO:0008374|O-acyltransferase activity;GO:0008970|phospholipase A1 activity;GO:0016411|acylglycerol O-acyltransferase activity;GO:0047499|calcium-independent phospholipase A2 activity;GO:0052739|phosphatidylserine 1-acylhydrolase activity;GO:0052740|1-acyl-2-lysophosphatidylserine acylhydrolase activity;GO:0102545|phosphatidyl phospholipase B activity;","K06129","LYPLA3; lysophospholipase III [EC:3.1.1.5]"]
["ENSRNOG00000053891",81,6.81495676,5,0.321652191,21.18734755,4.405131083,{"v":2.26e-22,"d":"2.26E-22"},{"v":7.17e-22,"d":"7.17E-22"},"up","yes","Phf11","protein_coding","chr15:33390292-33413009:-","gi|66730368|ref|NP_001019443.1|",1503,0,"PHD finger protein 11 [Rattus norvegicus]","gi|66730367|ref|NM_001024272.1|",1453,0,"Rattus norvegicus PHD finger protein 11 (Phf11), mRNA","Q5I0E2",583,0,"PHD finger protein 11",".",".",".",".","pfam13771","zf-HC5HC2H","PHD-like zinc-binding domain. The members of this family are annotated as containing PHD domain, but the zinc-binding region here is not typical of PHD domains. The conformation here is a well-conserved cysteine-histidine rich region spanning 90 residues, where the Cys and His are arranged as HxxC(31)CxxC(6)CxxCxxxxCxxxxHxxC (21)CxxH.",".","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0031965|nuclear membrane;","GO:0046872|metal ion binding;",".","."]
["ENSRNOG00000037331",138,11.61066707,35,2.251565336,5.156708928,2.366450615,2.66E-22,{"v":8.4e-22,"d":"8.40E-22"},"up","yes","Cd33","protein_coding","chr1:93930971-93950149:-","gi|149056119|gb|EDM07550.1|",1392,0,"rCG54544 [Rattus norvegicus]","gi|672036639|ref|XM_008759423.1|",1186,0,"PREDICTED: Rattus norvegicus CD33 molecule (Cd33), mRNA","Q63994",429,{"v":2e-144,"d":"2.00E-144"},"Myeloid cell surface antigen CD33",".",".",".",".","pfam10471","APC_CDC26","Anaphase-promoting complex APC subunit 1. The anaphase-promoting complex (APC) or cyclosome is a cell cycle-regulated ubiquitin-protein ligase that regulates important events in mitosis such as the initiation of anaphase and exit from telophase. The APC, in conjunction with other enzymes, assembles multi-ubiquitin chains on a variety of regulatory proteins thereby targeting them for proteolysis by the 26S proteasome. CDC26 is one of the nine or so subunits identified within APC but its exact function is not known. The APC/C becomes active at the metaphase/anaphase transition and remains active during G1 phase. One mechanism linked to activation of the APC/C is phosphorylation. The yeast APC/C is composed of at least 13 subunits, but the function of many of the subunits is unknown. Hcn1 is the smallest subunit of the S. pombe APC/C, and is found to be essential for cell viability, APC/C integrity, and proper APC/C regulation. In addition, Hcn1 phosphorylation indicates a specific role for the phosphorylation of this subunit late in the cell cycle.","GO:0002765|immune response-inhibiting signal transduction;GO:0007155|cell adhesion;GO:0032691|negative regulation of interleukin-1 beta production;GO:0032717|negative regulation of interleukin-8 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0050714|positive regulation of protein secretion;GO:0051926|negative regulation of calcium ion transport;GO:0098609|cell-cell adhesion;GO:1903615|positive regulation of protein tyrosine phosphatase activity;","GO:0005654|nucleoplasm;GO:0005777|peroxisome;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0019903|protein phosphatase binding;GO:0033691|sialic acid binding;","K06473","CD33, SIGLEC3; CD33 antigen"]
["ENSRNOG00000009919",83,6.983227298,0,0.032165219,217.1049194,7.762248606,{"v":3.02e-22,"d":"3.02E-22"},{"v":9.54e-22,"d":"9.54E-22"},"up","yes","Acod1","protein_coding","chr15:79871827-79880529:+","gi|157822797|ref|NP_001100752.1|",2508,0,"cis-aconitate decarboxylase [Rattus norvegicus]","gi|157822796|ref|NM_001107282.1|",2124,0,"Rattus norvegicus immunoresponsive gene 1 (Irg1), mRNA","P54987",909,0,"Cis-aconitate decarboxylase","PA0881",96.7,{"v":3e-20,"d":"3.00E-20"},"COG2079","pfam03972","MmgE_PrpD","MmgE/PrpD family. This family includes 2-methylcitrate dehydratase EC:4.2.1.79 (PrpD) that is required for propionate catabolism. It catalyses the third step of the 2-methylcitric acid cycle.","GO:0002760|positive regulation of antimicrobial humoral response;GO:0006952|defense response;GO:0007566|embryo implantation;GO:0009617|response to bacterium;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0032480|negative regulation of type I interferon production;GO:0032496|response to lipopolysaccharide;GO:0034136|negative regulation of toll-like receptor 2 signaling pathway;GO:0034144|negative regulation of toll-like receptor 4 signaling pathway;GO:0035458|cellular response to interferon-beta;GO:0045824|negative regulation of innate immune response;GO:0050728|negative regulation of inflammatory response;GO:0051607|defense response to virus;GO:0071219|cellular response to molecule of bacterial origin;GO:0071222|cellular response to lipopolysaccharide;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071393|cellular response to progesterone stimulus;GO:0072573|tolerance induction to lipopolysaccharide;GO:2000379|positive regulation of reactive oxygen species metabolic process;","GO:0005739|mitochondrion;","GO:0047613|aconitate decarboxylase activity;","K17724","IRG1; aconitate decarboxylase [EC:4.1.1.6]"]
["ENSRNOG00000025522",333,28.01704446,183,11.77247019,2.37987814,1.250887704,{"v":3.81e-22,"d":"3.81E-22"},{"v":1.2E-21,"d":"1.20E-21"},"up","yes","Atf7ip2","protein_coding","chr10:5403105-5446142:-","gi|564370396|ref|XP_006245794.1|",2281,0,"PREDICTED: activating transcription factor 7-interacting protein 2 isoform X2 [Rattus norvegicus]","gi|672066595|ref|XM_006245732.2|",2020,0,"PREDICTED: Rattus norvegicus activating transcription factor 7 interacting protein 2 (Atf7ip2), transcript variant X2, mRNA","Q3UL97",773,0,"Activating transcription factor 7-interacting protein 2",".",".",".",".","pfam00041","fn3","Fibronectin type III domain.",".","GO:0005634|nucleus;",".",".","."]
["ENSRNOG00000016326",363,30.54110252,209,13.44506158,2.271547983,1.183675781,{"v":3.97e-22,"d":"3.97E-22"},{"v":1.25e-21,"d":"1.25E-21"},"up","yes","Cx3cl1","protein_coding","chr19:10227340-10236833:-","gi|672084211|ref|XP_008770551.1|",1853,0,"PREDICTED: fractalkine isoform X1 [Rattus norvegicus]","gi|672084210|ref|XM_008772329.1|",2973,0,"PREDICTED: Rattus norvegicus chemokine (C-X3-C motif) ligand 1 (Cx3cl1), transcript variant X1, mRNA","O55145",711,0,"Fractalkine",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0001666|response to hypoxia;GO:0001774|microglial cell activation;GO:0002052|positive regulation of neuroblast proliferation;GO:0002523|leukocyte migration involved in inflammatory response;GO:0002548|monocyte chemotaxis;GO:0002931|response to ischemia;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007155|cell adhesion;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007568|aging;GO:0008284|positive regulation of cell proliferation;GO:0010759|positive regulation of macrophage chemotaxis;GO:0010976|positive regulation of neuron projection development;GO:0019221|cytokine-mediated signaling pathway;GO:0030168|platelet activation;GO:0030335|positive regulation of cell migration;GO:0030336|negative regulation of cell migration;GO:0030593|neutrophil chemotaxis;GO:0031664|regulation of lipopolysaccharide-mediated signaling pathway;GO:0032233|positive regulation of actin filament bundle assembly;GO:0032690|negative regulation of interleukin-1 alpha production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032914|positive regulation of transforming growth factor beta1 production;GO:0033622|integrin activation;GO:0035425|autocrine signaling;GO:0042060|wound healing;GO:0043066|negative regulation of apoptotic process;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043410|positive regulation of MAPK cascade;GO:0043547|positive regulation of GTPase activity;GO:0045766|positive regulation of angiogenesis;GO:0045785|positive regulation of cell adhesion;GO:0045906|negative regulation of vasoconstriction;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048245|eosinophil chemotaxis;GO:0048246|macrophage chemotaxis;GO:0048247|lymphocyte chemotaxis;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0050729|positive regulation of inflammatory response;GO:0050902|leukocyte adhesive activation;GO:0050918|positive chemotaxis;GO:0051041|positive regulation of calcium-independent cell-cell adhesion;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;GO:0051897|positive regulation of protein kinase B signaling;GO:0060055|angiogenesis involved in wound healing;GO:0060080|inhibitory postsynaptic potential;GO:0060326|cell chemotaxis;GO:0061518|microglial cell proliferation;GO:0070050|neuron cellular homeostasis;GO:0070098|chemokine-mediated signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0098609|cell-cell adhesion;GO:0110091|negative regulation of hippocampal neuron apoptotic process;GO:1900450|negative regulation of glutamate receptor signaling pathway;GO:1903721|positive regulation of I-kappaB phosphorylation;GO:1903979|negative regulation of microglial cell activation;GO:1904141|positive regulation of microglial cell migration;GO:2001234|negative regulation of apoptotic signaling pathway;GO:2001240|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0042995|cell projection;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0044297|cell body;GO:0048471|perinuclear region of cytoplasm;GO:0098794|postsynapse;","GO:0005178|integrin binding;GO:0008009|chemokine activity;GO:0031737|CX3C chemokine receptor binding;GO:0042056|chemoattractant activity;GO:0045237|CXCR1 chemokine receptor binding;GO:0048020|CCR chemokine receptor binding;","K05508","CX3CL1, NTT; C-X3-C motif chemokine 1"]
["ENSRNOG00000000562",93,7.824579984,11,0.70763482,11.05736994,3.466936367,{"v":4.76e-22,"d":"4.76E-22"},{"v":1.49e-21,"d":"1.49E-21"},"up","yes","Prf1","protein_coding","chr20:29246202-29251701:+","gi|149038739|gb|EDL93028.1|",3110,0,"perforin 1 (pore forming protein), isoform CRA_a [Rattus norvegicus]","gi|59709458|ref|NM_017330.2|",1919,0,"Rattus norvegicus perforin 1 (Prf1), mRNA","P35763",1125,0,"Perforin-1",".",".",".",".","pfam01823","MACPF","MAC/Perforin domain. The membrane-attack complex (MAC) of the complement system forms transmembrane channels. These channels disrupt the phospholipid bilayer of target cells, leading to cell lysis and death. A number of proteins participate in the assembly of the MAC. Freshly activated C5b binds to C6 to form a C5b-6 complex, then to C7 forming the C5b-7 complex. The C5b-7 complex binds to C8, which is composed of three chains (alpha, beta, and gamma), thus forming the C5b-8 complex. C5b-8 subsequently binds to C9 and acts as a catalyst in the polymerization of C9. Active MAC has a subunit composition of C5b-C6-C7-C8-C9{n}. Perforin is a protein found in cytolytic T-cell and killer cells. In the presence of calcium, perforin polymerizes into transmembrane tubules and is capable of lysing, non-specifically, a variety of target cells. There are a number of regions of similarity in the sequences of complement components C6, C7, C8-alpha, C8-beta, C9 and perforin. The X-ray crystal structure of a MACPF domain reveals that it shares a common fold with bacterial cholesterol dependent cytolysins (pfam01289) such as perfringolysin O. Three key pieces of evidence suggests that MACPF domains and CDCs are homologous: Functional similarity (pore formation), conservation of three glycine residues at a hinge in both families and conservation of a complex core fold.","GO:0001771|immunological synapse formation;GO:0001913|T cell mediated cytotoxicity;GO:0002357|defense response to tumor cell;GO:0002418|immune response to tumor cell;GO:0006915|apoptotic process;GO:0007623|circadian rhythm;GO:0019835|cytolysis;GO:0045471|response to ethanol;GO:0051260|protein homooligomerization;GO:0051607|defense response to virus;GO:0051712|positive regulation of killing of cells of other organism;GO:0055085|transmembrane transport;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0031410|cytoplasmic vesicle;GO:0031904|endosome lumen;GO:0044194|cytolytic granule;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;GO:0022829|wide pore channel activity;GO:0042802|identical protein binding;","K07818","PRF1; perforin 1"]
["ENSRNOG00000002396",118,9.9279617,24,1.543930516,6.430316387,2.684889723,5.26E-22,1.64E-21,"up","yes","Serpinb8","protein_coding","chr13:23626945-23650835:+","gi|157786978|ref|NP_001099418.1|",1920,0,"serpin B8 [Rattus norvegicus]","gi|157786977|ref|NM_001105948.1|",2468,0,"Rattus norvegicus serpin peptidase inhibitor, clade B (ovalbumin), member 8 (Serpinb8), mRNA","O08800",681,0,"Serpin B8","MA2246",181,{"v":1e-48,"d":"1.00E-48"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0008150|biological_process;GO:0010951|negative regulation of endopeptidase activity;GO:0090136|epithelial cell-cell adhesion;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0003674|molecular_function;GO:0004867|serine-type endopeptidase inhibitor activity;","K13965","SERPINB8; serpin B8"]
["ENSRNOG00000018785",272,22.88479307,133,8.555948279,2.674723166,1.41938958,{"v":5.55e-22,"d":"5.55E-22"},{"v":1.72e-21,"d":"1.72E-21"},"up","yes","Slc16a13","protein_coding","chr10:54926760-54937788:-","gi|53850584|ref|NP_001005530.1|",1511,0,"monocarboxylate transporter 13 [Rattus norvegicus]","gi|53850583|ref|NM_001005530.1|",1367,0,"Rattus norvegicus solute carrier family 16, member 13 (Slc16a13), mRNA","Q66HE2",586,0,"Monocarboxylate transporter 13",".",".",".",".","pfam07690","MFS_1","Major Facilitator Superfamily.","GO:0015718|monocarboxylic acid transport;GO:0055085|transmembrane transport;","GO:0000139|Golgi membrane;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;","GO:0008028|monocarboxylic acid transmembrane transporter activity;GO:0015293|symporter activity;","K08189","SLC16A13; MFS transporter, MCT family, solute carrier family 16 (monocarboxylic acid transporters), member 13"]
["ENSRNOG00000029768",202,16.99532427,79,5.082104617,3.344150809,1.741639909,{"v":5.55e-22,"d":"5.55E-22"},{"v":1.72e-21,"d":"1.72E-21"},"up","yes","Ccl12","protein_coding","chr10:67070230-67071780:+","gi|157786668|ref|NP_001099292.1|",454,{"v":6e-55,"d":"6.00E-55"},"chemokine (C-C motif) ligand 12 precursor [Rattus norvegicus]","gi|157786667|ref|NM_001105822.1|",540,0,"Rattus norvegicus chemokine (C-C motif) ligand 12 (Ccl12), mRNA","Q62401",154,{"v":1E-46,"d":"1.00E-46"},"C-C motif chemokine 12",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0001525|angiogenesis;GO:0002548|monocyte chemotaxis;GO:0002687|positive regulation of leukocyte migration;GO:0006468|protein phosphorylation;GO:0006816|calcium ion transport;GO:0006874|cellular calcium ion homeostasis;GO:0006887|exocytosis;GO:0006954|inflammatory response;GO:0007010|cytoskeleton organization;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007267|cell-cell signaling;GO:0008360|regulation of cell shape;GO:0030593|neutrophil chemotaxis;GO:0031640|killing of cells of other organism;GO:0043547|positive regulation of GTPase activity;GO:0044828|negative regulation by host of viral genome replication;GO:0048245|eosinophil chemotaxis;GO:0048247|lymphocyte chemotaxis;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098|chemokine-mediated signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070664|negative regulation of leukocyte proliferation;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;","GO:0005575|cellular_component;GO:0005615|extracellular space;","GO:0003674|molecular_function;GO:0004672|protein kinase activity;GO:0008009|chemokine activity;GO:0016004|phospholipase activator activity;GO:0031727|CCR2 chemokine receptor binding;GO:0048020|CCR chemokine receptor binding;","K14624","CCL2, MCP1; C-C motif chemokine 2"]
["ENSRNOG00000017484",207,17.41600061,83,5.339426369,3.26177372,1.705656701,{"v":6.96e-22,"d":"6.96E-22"},{"v":2.16e-21,"d":"2.16E-21"},"up","yes","Gja5","protein_coding","chr2:184564475-184621952:+","gi|9506725|ref|NP_062153.1|",1836,0,"gap junction alpha-5 protein [Rattus norvegicus]","gi|672043500|ref|XM_008761328.1|",3027,0,"PREDICTED: Rattus norvegicus gap junction protein, alpha 5 (Gja5), transcript variant X1, mRNA","P28234",711,0,"Gap junction alpha-5 protein",".",".",".",".","pfam00029","Connexin","Connexin.","GO:0001501|skeletal system development;GO:0001525|angiogenesis;GO:0001568|blood vessel development;GO:0003071|renal system process involved in regulation of systemic arterial blood pressure;GO:0003073|regulation of systemic arterial blood pressure;GO:0003105|negative regulation of glomerular filtration;GO:0003151|outflow tract morphogenesis;GO:0003158|endothelium development;GO:0003161|cardiac conduction system development;GO:0003174|mitral valve development;GO:0003193|pulmonary valve formation;GO:0003281|ventricular septum development;GO:0003283|atrial septum development;GO:0003284|septum primum development;GO:0003294|atrial ventricular junction remodeling;GO:0006813|potassium ion transport;GO:0007267|cell-cell signaling;GO:0007507|heart development;GO:0010643|cell communication by chemical coupling;GO:0010644|cell communication by electrical coupling;GO:0010649|regulation of cell communication by electrical coupling;GO:0010652|positive regulation of cell communication by chemical coupling;GO:0016264|gap junction assembly;GO:0030326|embryonic limb morphogenesis;GO:0035050|embryonic heart tube development;GO:0035922|foramen ovale closure;GO:0036120|cellular response to platelet-derived growth factor stimulus;GO:0042311|vasodilation;GO:0045776|negative regulation of blood pressure;GO:0045907|positive regulation of vasoconstriction;GO:0048844|artery morphogenesis;GO:0055085|transmembrane transport;GO:0055117|regulation of cardiac muscle contraction;GO:0060307|regulation of ventricular cardiac muscle cell membrane repolarization;GO:0060371|regulation of atrial cardiac muscle cell membrane depolarization;GO:0060373|regulation of ventricular cardiac muscle cell membrane depolarization;GO:0060412|ventricular septum morphogenesis;GO:0060413|atrial septum morphogenesis;GO:0061337|cardiac conduction;GO:0086005|ventricular cardiac muscle cell action potential;GO:0086015|SA node cell action potential;GO:0086044|atrial cardiac muscle cell to AV node cell communication by electrical coupling;GO:0086053|AV node cell to bundle of His cell communication by electrical coupling;GO:0086054|bundle of His cell to Purkinje myocyte communication by electrical coupling;GO:0086064|cell communication by electrical coupling involved in cardiac conduction;GO:0086065|cell communication involved in cardiac conduction;GO:0086067|AV node cell to bundle of His cell communication;GO:0086091|regulation of heart rate by cardiac conduction;GO:0097746|regulation of blood vessel diameter;GO:0098904|regulation of AV node cell action potential;GO:0098905|regulation of bundle of His cell action potential;GO:0098906|regulation of Purkinje myocyte action potential;GO:0098910|regulation of atrial cardiac muscle cell action potential;GO:1900133|regulation of renin secretion into blood stream;GO:1900825|regulation of membrane depolarization during cardiac muscle cell action potential;GO:1990029|vasomotion;","GO:0005887|integral component of plasma membrane;GO:0005921|gap junction;GO:0005922|connexin complex;GO:0014704|intercalated disc;GO:0042995|cell projection;","GO:0005243|gap junction channel activity;GO:0055077|gap junction hemi-channel activity;GO:0071253|connexin binding;GO:0086075|gap junction channel activity involved in cardiac conduction electrical coupling;GO:0086076|gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling;GO:0086077|gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling;GO:0086078|gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling;GO:0097718|disordered domain specific binding;","K07614","GJA5, CX40; gap junction alpha-5 protein"]
["ENSRNOG00000062846",88,7.403903641,9,0.578973944,12.78797383,3.676715792,{"v":7.77e-22,"d":"7.77E-22"},{"v":2.4e-21,"d":"2.40E-21"},"up","yes","Oas1k","protein_coding","chr12:35762468-35771710:-","gi|564379514|ref|XP_006249463.1|",1380,0,"PREDICTED: 2 ' -5 ' oligoadenylate synthetase 1K isoform X2 [Rattus norvegicus]","gi|57222307|ref|NM_001009489.1|",937,0,"Rattus norvegicus 2 ' -5 ' oligoadenylate synthetase 1K (Oas1k), mRNA","Q05961",387,{"v":2e-127,"d":"2.00E-127"},"2'-5'-oligoadenylate synthase 1A",".",".",".",".","pfam10421","OAS1_C","2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus. This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between 320 and 344 at the extreme C-terminal end. Oligoadenylate synthetases are antiviral enzymes that counteract vial attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesize 2'.5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication. This domain is often associated with NTP_transf_2 pfam01909.",".",".",".",".","."]
["ENSRNOG00000029670",276,23.22133415,137,8.813270031,2.634814781,1.397701549,8.32E-22,{"v":2.57e-21,"d":"2.57E-21"},"up","yes","RGD1564606","protein_coding","chr2:38451401-38453417:+","gi|530617155|ref|XP_005298314.1|",663,{"v":4e-83,"d":"4.00E-83"},"PREDICTED: 60S ribosomal protein L23a isoform X2 [Chrysemys picta bellii]","gi|672015379|ref|XR_599590.1|",560,0,"PREDICTED: Rattus norvegicus similar to 60S ribosomal protein L23a (RGD1564606), misc_RNA","P62752",259,{"v":2e-84,"d":"2.00E-84"},"60S ribosomal protein L23a","SPBC4F6.04",167,{"v":3E-49,"d":"3.00E-49"},"COG0089","pfam03939","Ribosomal_L23eN","Ribosomal protein L23, N-terminal domain. The N-terminal domain appears to be specific to the eukaryotic ribosomal proteins L25, L23, and L23a.","GO:0000027|ribosomal large subunit assembly;GO:0006412|translation;","GO:0022625|cytosolic large ribosomal subunit;","GO:0003735|structural constituent of ribosome;GO:0019843|rRNA binding;",".","."]
["ENSRNOG00000007544",210,17.66840642,86,5.532417684,3.193613972,1.675189938,{"v":1.17e-21,"d":"1.17E-21"},{"v":3.57e-21,"d":"3.57E-21"},"up","yes","Il23r","protein_coding","chr4:96580714-96674021:-","gi|392339985|ref|XP_003753958.1|",3326,0,"PREDICTED: interleukin-23 receptor isoform X1 [Rattus norvegicus]","gi|672018411|ref|XM_003753910.3|",1940,0,"PREDICTED: Rattus norvegicus interleukin 23 receptor (Il23r), transcript variant X1, mRNA","Q8K4B4",1108,0,"Interleukin-23 receptor",".",".",".",".","pfam09240","IL6Ra-bind","Interleukin-6 receptor alpha chain, binding. Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.","GO:0002230|positive regulation of defense response to virus by host;GO:0002827|positive regulation of T-helper 1 type immune response;GO:0008150|biological_process;GO:0019221|cytokine-mediated signaling pathway;GO:0032496|response to lipopolysaccharide;GO:0032693|negative regulation of interleukin-10 production;GO:0032729|positive regulation of interferon-gamma production;GO:0032735|positive regulation of interleukin-12 production;GO:0034341|response to interferon-gamma;GO:0038155|interleukin-23-mediated signaling pathway;","GO:0005575|cellular_component;GO:0009897|external side of plasma membrane;GO:0043235|receptor complex;GO:0072536|interleukin-23 receptor complex;","GO:0003674|molecular_function;GO:0004896|cytokine receptor activity;GO:0005143|interleukin-12 receptor binding;GO:0019955|cytokine binding;GO:0042019|interleukin-23 binding;GO:0042020|interleukin-23 receptor activity;","K05065","IL23R; interleukin 23 receptor"]
["ENSRNOG00000007437",281,23.64201049,142,9.134922222,2.588091055,1.371888375,{"v":1.35e-21,"d":"1.35E-21"},{"v":4.12e-21,"d":"4.12E-21"},"up","yes","Irf5","protein_coding","chr4:58127640-58139267:+","gi|564346042|ref|XP_006236242.1|",2637,0,"PREDICTED: interferon regulatory factor 5 isoform X1 [Rattus norvegicus]","gi|672049100|ref|XM_006236180.2|",2942,0,"PREDICTED: Rattus norvegicus interferon regulatory factor 5 (Irf5), transcript variant X1, mRNA","P56477",904,0,"Interferon regulatory factor 5",".",".",".",".","pfam10401","IRF-3","Interferon-regulatory factor 3. This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1).  Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.","GO:0002376|immune system process;GO:0006357|regulation of transcription by RNA polymerase II;GO:0019221|cytokine-mediated signaling pathway;GO:0032481|positive regulation of type I interferon production;GO:0032494|response to peptidoglycan;GO:0032495|response to muramyl dipeptide;GO:0043065|positive regulation of apoptotic process;GO:0045087|innate immune response;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051607|defense response to virus;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0019901|protein kinase binding;GO:0042802|identical protein binding;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09446","IRF5; interferon regulatory factor 5"]
["ENSRNOG00000063618",87,7.319768372,9,0.578973944,12.64265595,3.660227669,1.53E-21,{"v":4.68e-21,"d":"4.68E-21"},"up","yes","Cxcr2","protein_coding","chr9:75729115-75739425:+","gi|8393600|ref|NP_058879.1|",1890,0,"C-X-C chemokine receptor type 2 [Rattus norvegicus]","gi|672065525|ref|XM_008767214.1|",2176,0,"PREDICTED: Rattus norvegicus chemokine (C-X-C motif) receptor 2 (Cxcr2), transcript variant X2, mRNA","P35407",732,0,"C-X-C chemokine receptor type 2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.",".",".",".",".","."]
["ENSRNOG00000039891",177,14.89194255,63,4.052817606,3.674466507,1.877534801,{"v":2.12e-21,"d":"2.12E-21"},{"v":6.42e-21,"d":"6.42E-21"},"up","yes","Adgrg5","protein_coding","chr19:10079375-10097214:-","gi|672084140|ref|XP_008770528.1|",2552,0,"PREDICTED: probable G-protein coupled receptor 114 isoform X5 [Rattus norvegicus]","gi|157817834|ref|NM_001107410.1|",2766,0,"Rattus norvegicus adhesion G protein-coupled receptor G5 (Adgrg5), mRNA","Q3V3Z3",858,0,"Adhesion G-protein coupled receptor G5",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0007166|cell surface receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;","GO:0005887|integral component of plasma membrane;","GO:0004930|G protein-coupled receptor activity;","K08459","ADGRG5, GPR114; adhesion G-protein coupled receptor G5"]
["ENSRNOG00000021814",181,15.22848363,66,4.24580892,3.586709603,1.842660942,{"v":2.44e-21,"d":"2.44E-21"},7.37E-21,"up","yes","Tnfrsf25","protein_coding","chr5:162622075-162626341:+","gi|212549637|ref|NP_001131116.1|",1788,0,"tumor necrosis factor receptor superfamily member 25 precursor [Rattus norvegicus]","gi|212549636|ref|NM_001137644.1|",1626,0,"Rattus norvegicus tumor necrosis factor receptor superfamily, member 25 (Tnfrsf25), mRNA","Q93038",432,{"v":1e-145,"d":"1.00E-145"},"Tumor necrosis factor receptor superfamily member 25",".",".",".",".","pfam00531","Death","Death domain.","GO:0006915|apoptotic process;GO:0007165|signal transduction;","GO:0005886|plasma membrane;",".","K05160","TNFRSF25; tumor necrosis factor receptor superfamily member 25"]
["ENSRNOG00000008005",367,30.87764359,217,13.95970509,2.211912315,1.145294195,{"v":2.73e-21,"d":"2.73E-21"},8.25E-21,"up","yes","Akna","protein_coding","chr5:76777415-76816017:-","gi|157822031|ref|NP_001102138.1|",6575,0,"AT-hook-containing transcription factor [Rattus norvegicus]","gi|157822030|ref|NM_001108668.1|",5353,0,"Rattus norvegicus AT-hook transcription factor (Akna), mRNA","Q80VW7",2062,0,"AT-hook-containing transcription factor",".",".",".",".","pfam12443","AKNA","AT-hook-containing transcription factor. This domain family is found in eukaryotes, and is approximately 110 amino acids in length. This family contains a transcription factor which regulates the expression of the costimulatory molecules on lymphocytes.","GO:0001837|epithelial to mesenchymal transition;GO:0021849|neuroblast division in subventricular zone;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050727|regulation of inflammatory response;GO:0060232|delamination;GO:0060234|neuroblast delamination;","GO:0001650|fibrillar center;GO:0005654|nucleoplasm;GO:0005813|centrosome;GO:0005814|centriole;GO:0005829|cytosol;GO:0005874|microtubule;GO:0043231|intracellular membrane-bounded organelle;",".","K21404","AKNA; AT-hook-containing transcription factor"]
["ENSRNOG00000065666",197,16.57464792,78,5.017774178,3.303187297,1.723858775,{"v":3.41e-21,"d":"3.41E-21"},1.03E-20,"up","yes","ENSRNOG00000065666","protein_coding","chr4:31319843-31342307:-","gi|672018006|ref|XP_008773888.1|",6607,0,"PREDICTED: LOW QUALITY PROTEIN: sterile alpha motif domain-containing protein 9-like [Rattus norvegicus]","gi|672018005|ref|XM_008775666.1|",5138,0,"PREDICTED: Rattus norvegicus similar to sterile alpha motif domain containing 9-like (LOC684193), mRNA","Q69Z37",2094,0,"Sterile alpha motif domain-containing protein 9-like",".",".",".",".","pfam02994","Transposase_22","L1 transposable element.",".",".",".",".","."]
["ENSRNOG00000069663",146,12.28374922,43,2.766208842,4.44064419,2.150768979,4.28E-21,{"v":1.28e-20,"d":"1.28E-20"},"up","yes","Arl4c","protein_coding","chr9:89298005-89304513:-","gi|29436760|gb|AAH49804.1|",1153,{"v":3e-151,"d":"3.00E-151"},"Arl4c protein, partial [Mus musculus]","gi|75905681|gb|AC166829.3|",1467,0,"Mus musculus BAC clone RP23-299M19 from chromosome 1, complete sequence","P61208",373,{"v":2e-124,"d":"2.00E-124"},"ADP-ribosylation factor-like protein 4C",".",".",".",".","pfam00025","Arf","ADP-ribosylation factor family. Pfam combines a number of different Prosite families together",".",".",".",".","."]
["ENSRNOG00000023005",83,6.983227298,8,0.514643505,13.56905746,3.762248606,{"v":5.32e-21,"d":"5.32E-21"},{"v":1.59e-20,"d":"1.59E-20"},"up","yes","ENSRNOG00000023005","protein_coding","chrX:74312661-74316635:+","gi|157822063|ref|NP_001102909.1|",1613,0,"uncharacterized protein LOC681325 [Rattus norvegicus]","gi|298915231|emb|FQ226125.1|",2741,0,"Rattus norvegicus TL0AEA37YM22 mRNA sequence",".",".",".",".",".",".",".",".","pfam15133","DUF4569","Domain of unknown function (DUF4569). This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. This family includes human protein CXorf21.","GO:0034121|regulation of toll-like receptor signaling pathway;GO:0035751|regulation of lysosomal lumen pH;",".",".",".","."]
["ENSRNOG00000006319",126,10.60104385,31,1.994243584,5.315821967,2.410292788,{"v":6.52e-21,"d":"6.52E-21"},1.95E-20,"up","yes","Cxcr6","protein_coding","chr8:123416325-123439526:+","gi|149018110|gb|EDL76751.1|",1844,0,"rCG26104 [Rattus norvegicus]","gi|156564360|ref|NM_001102587.1|",1055,0,"Rattus norvegicus chemokine (C-X-C motif) receptor 6 (Cxcr6), mRNA","Q9EQ16",621,0,"C-X-C chemokine receptor type 6",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0019722|calcium-mediated signaling;GO:0060326|cell chemotaxis;GO:0070098|chemokine-mediated signaling pathway;","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0015026|coreceptor activity;GO:0016493|C-C chemokine receptor activity;GO:0016494|C-X-C chemokine receptor activity;GO:0019957|C-C chemokine binding;GO:0019958|C-X-C chemokine binding;","K04191","CXCR6, CD186; C-X-C chemokine receptor type 6"]
["ENSRNOG00000006946",360,30.28869671,213,13.70238333,2.210469228,1.144352651,{"v":6.88e-21,"d":"6.88E-21"},2.05E-20,"up","yes","Arhgap9","protein_coding","chr7:63148900-63157524:+","gi|124248581|ref|NP_001074258.1|",3057,0,"rho GTPase-activating protein 9 isoform 1 [Rattus norvegicus]","gi|124248580|ref|NM_001080789.1|",1954,0,"Rattus norvegicus Rho GTPase activating protein 9 (Arhgap9), transcript variant 1, mRNA","Q9BRR9",553,0,"Rho GTPase-activating protein 9",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0007165|signal transduction;GO:0043087|regulation of GTPase activity;","GO:0005737|cytoplasm;","GO:0005096|GTPase activator activity;GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;","K20634","ARHGAP9; Rho GTPase-activating protein 9"]
["ENSRNOG00000015674",241,20.27659974,113,7.269339515,2.789331782,1.479919549,{"v":7.98e-21,"d":"7.98E-21"},{"v":2.37e-20,"d":"2.37E-20"},"up","yes","Acap1","protein_coding","chr10:54605323-54619472:-","gi|300390201|ref|NP_001099266.2|",3566,0,"arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 [Rattus norvegicus]","gi|300390200|ref|NM_001105796.2|",2468,0,"Rattus norvegicus ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 (Acap1), mRNA","Q8K2H4",1313,0,"Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1","SPBC17G9.08c_2",97.1,{"v":2e-21,"d":"2.00E-21"},"COG5347","pfam01412","ArfGap","Putative GTPase activating protein for Arf. Putative zinc fingers with GTPase activating proteins (GAPs) towards the small GTPase, Arf. The GAP of ARD1 stimulates GTPase hydrolysis for ARD1 but not ARFs.","GO:0050790|regulation of catalytic activity;",".","GO:0005096|GTPase activator activity;GO:0046872|metal ion binding;","K12489","ACAP; Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein"]
["ENSRNOG00000070619",155,13.04096664,50,3.216521909,4.054368976,2.01947739,1.07E-20,{"v":3.16e-20,"d":"3.16E-20"},"up","yes","ENSRNOG00000070619","lncRNA","chr7:15903881-15929311:-","gi|672058315|ref|XP_008763488.1|",413,{"v":1E-42,"d":"1.00E-42"},"PREDICTED: inactive phospholipase C-like protein 2 [Rattus norvegicus]","gi|672058313|ref|XR_593304.1|",2178,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102552467 (LOC102552467), transcript variant X3, ncRNA",".",".",".",".",".",".",".",".","pfam04822","Takusan","Takusan. This domain is named takusan, which is a Japanese word meaning 'many'. Members of this family regulate synaptic activity.",".",".",".",".","."]
["ENSRNOG00000001427",204,17.1635948,85,5.468087246,3.138866304,1.650243581,1.13E-20,{"v":3.33e-20,"d":"3.33E-20"},"up","yes","Orai2","protein_coding","chr12:20497317-20520428:+","gi|281371452|ref|NP_001163874.1|",1564,0,"protein orai-2 [Rattus norvegicus]","gi|281371451|ref|NM_001170403.1|",4047,0,"Rattus norvegicus ORAI calcium release-activated calcium modulator 2 (Orai2), mRNA","Q8BH10",515,{"v":6e-166,"d":"6.00E-166"},"Protein orai-2",".",".",".",".","pfam07856","Orai-1","Mediator of CRAC channel activity. ORAI-1 is a protein homologue of Drosophila Orai and human Orai1, Orai2 and Orai3. ORAI-1 GFP reporters are co- expressed with STIM-1 (ER CA(2+) sensors) in the gonad and intestine. The protein has four predicted transmembrane domains with a highly conserved region between TM2 ad TM3. This conserved domain is thought to function in channel regulation. ORAI1- related proteins are required for the production of the calcium channel, CRAC, along with STIM1-related proteins.","GO:0002115|store-operated calcium entry;GO:0008150|biological_process;GO:0070588|calcium ion transmembrane transport;","GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030426|growth cone;","GO:0003674|molecular_function;GO:0015279|store-operated calcium channel activity;","K16057","ORAI2; calcium release-activated calcium channel protein 2"]
["ENSRNOG00000070904",277,23.30546942,143,9.19925266,2.533408993,1.341080004,1.22E-20,{"v":3.6e-20,"d":"3.60E-20"},"up","yes","ENSRNOG00000070904","lncRNA","chr14:97690183-97693264:-",".",".",".",".","gi|23953990|emb|AL805916.7|",475,0,"Mouse DNA sequence from clone RP23-164N15 on chromosome 11, complete sequence",".",".",".",".",".",".",".",".","pfam08602","Mgr1","Mgr1-like, i-AAA protease complex subunit. The S. cerevisiae Mgr1 protein has been shown to be required for mitochondrial viability in yeast lacking mitochondrial DNA. It is a mitochondrial inner membrane protein, which interacts with Yme1 and is a new subunit of the i-AAA protease complex.",".",".",".",".","."]
["ENSRNOG00000039754",264,22.21171092,133,8.555948279,2.596054838,1.376320859,1.76E-20,{"v":5.16e-20,"d":"5.16E-20"},"up","yes","Rab7b","protein_coding","chr13:43121226-43147581:+","gi|149058661|gb|EDM09818.1|",1080,{"v":1e-138,"d":"1.00E-138"},"similar to RAB7-like protein (predicted), isoform CRA_a [Rattus norvegicus]","gi|404247438|ref|NM_001109328.2|",2500,0,"Rattus norvegicus Rab7b, member RAS oncogene family (Rab7b), mRNA","Q8VEA8",401,{"v":5e-133,"d":"5.00E-133"},"Ras-related protein Rab-7b",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0008333|endosome to lysosome transport;GO:0032755|positive regulation of interleukin-6 production;GO:0034144|negative regulation of toll-like receptor 4 signaling pathway;GO:0034164|negative regulation of toll-like receptor 9 signaling pathway;GO:0034499|late endosome to Golgi transport;GO:0045654|positive regulation of megakaryocyte differentiation;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0071346|cellular response to interferon-gamma;GO:0090385|phagosome-lysosome fusion;","GO:0005764|lysosome;GO:0005770|late endosome;GO:0005794|Golgi apparatus;GO:0005802|trans-Golgi network;GO:0045335|phagocytic vesicle;","GO:0003924|GTPase activity;GO:0005525|GTP binding;","K07898","RAB7B; Ras-related protein Rab-7B"]
["ENSRNOG00000013914",107,9.002473745,21,1.350939202,6.663862987,2.736358738,{"v":1.77e-20,"d":"1.77E-20"},{"v":5.17e-20,"d":"5.17E-20"},"up","yes","Gpr132","protein_coding","chr6:131924160-131942168:-","gi|564357535|ref|XP_006240723.1|",2445,0,"PREDICTED: probable G-protein coupled receptor 132 isoform X1 [Rattus norvegicus]","gi|672057201|ref|XM_006240661.2|",3186,0,"PREDICTED: Rattus norvegicus G protein-coupled receptor 132 (Gpr132), transcript variant X1, mRNA","Q9Z282",635,0,"Probable G-protein coupled receptor 132",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0000082|G1/S transition of mitotic cell cycle;GO:0007186|G protein-coupled receptor signaling pathway;GO:0010972|negative regulation of G2/M transition of mitotic cell cycle;","GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;","K08426","GPR132, G2A; G protein-coupled receptor 132"]
["ENSRNOG00000009705",271,22.8006578,139,8.941930908,2.549858419,1.350417143,{"v":2e-20,"d":"2.00E-20"},{"v":5.83e-20,"d":"5.83E-20"},"up","yes","Lck","protein_coding","chr5:141888326-141903794:-","gi|564352993|ref|XP_006238994.1|",2810,0,"PREDICTED: proto-oncogene tyrosine-protein kinase LCK isoform X2 [Rattus norvegicus]","gi|672054094|ref|XM_006238932.2|",2118,0,"PREDICTED: Rattus norvegicus LCK proto-oncogene, Src family tyrosine kinase (Lck), transcript variant X1, mRNA","Q01621",1065,0,"Proto-oncogene tyrosine-protein kinase LCK",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0006468|protein phosphorylation;GO:0006470|protein dephosphorylation;GO:0006882|cellular zinc ion homeostasis;GO:0006915|apoptotic process;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007166|cell surface receptor signaling pathway;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007568|aging;GO:0009410|response to xenobiotic stimulus;GO:0009612|response to mechanical stimulus;GO:0010038|response to metal ion;GO:0010043|response to zinc ion;GO:0010628|positive regulation of gene expression;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0030154|cell differentiation;GO:0030217|T cell differentiation;GO:0034116|positive regulation of heterotypic cell-cell adhesion;GO:0035556|intracellular signal transduction;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0042542|response to hydrogen peroxide;GO:0045087|innate immune response;GO:0045588|positive regulation of gamma-delta T cell differentiation;GO:0045589|regulation of regulatory T cell differentiation;GO:0046777|protein autophosphorylation;GO:0050853|B cell receptor signaling pathway;GO:0050856|regulation of T cell receptor signaling pathway;GO:0050870|positive regulation of T cell activation;GO:0051209|release of sequestered calcium ion into cytosol;GO:0070474|positive regulation of uterine smooth muscle contraction;GO:1903039|positive regulation of leukocyte cell-cell adhesion;GO:2001244|positive regulation of intrinsic apoptotic signaling pathway;","GO:0000242|pericentriolar material;GO:0001772|immunological synapse;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0030139|endocytic vesicle;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0045121|membrane raft;GO:0098978|glutamatergic synapse;GO:0099091|postsynaptic specialization, intracellular component;","GO:0001784|phosphotyrosine residue binding;GO:0003823|antigen binding;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0004722|protein serine/threonine phosphatase activity;GO:0005102|signaling receptor binding;GO:0005524|ATP binding;GO:0008022|protein C-terminus binding;GO:0016004|phospholipase activator activity;GO:0019901|protein kinase binding;GO:0019903|protein phosphatase binding;GO:0042169|SH2 domain binding;GO:0042608|T cell receptor binding;GO:0042609|CD4 receptor binding;GO:0042610|CD8 receptor binding;GO:0042802|identical protein binding;GO:0043274|phospholipase binding;GO:0043548|phosphatidylinositol 3-kinase binding;GO:0044877|protein-containing complex binding;GO:0051117|ATPase binding;GO:1990405|protein antigen binding;","K05856","LCK; lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2]"]
["ENSRNOG00000042771",256,21.53862877,127,8.169965649,2.636318156,1.398524488,2.34E-20,{"v":6.8e-20,"d":"6.80E-20"},"up","yes","Apol3","protein_coding","chr7:109288725-109297723:+","gi|61557187|ref|NP_001013193.1|",1434,0,"apolipoprotein L, 3 [Rattus norvegicus]","gi|475505004|ref|NM_001277359.1|",1298,0,"Rattus norvegicus apolipoprotein L, 3 (Apol3), transcript variant 1, mRNA","O95236",185,{"v":8e-51,"d":"8.00E-51"},"Apolipoprotein L3",".",".",".",".","pfam05461","ApoL","Apolipoprotein L. Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.","GO:0006869|lipid transport;GO:0042157|lipoprotein metabolic process;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;","GO:0005576|extracellular region;","GO:0008289|lipid binding;","K14480","APOL; apolipoprotein L"]
["ENSRNOG00000000463",270,22.71652253,139,8.941930908,2.540449347,1.345083699,{"v":3.04e-20,"d":"3.04E-20"},{"v":8.83e-20,"d":"8.83E-20"},"up","yes","Col11a2","protein_coding","chr20:4786929-4815985:-","gi|564396638|ref|XP_006255990.1|",2647,0,"PREDICTED: collagen alpha-2(XI) chain isoform X2 [Rattus norvegicus]","gi|672085636|ref|XM_006255928.2|",6123,0,"PREDICTED: Rattus norvegicus collagen, type XI, alpha 2 (Col11a2), transcript variant X2, mRNA","Q64739",999,0,"Collagen alpha-2(XI) chain",".",".",".",".","pfam01410","COLFI","Fibrillar collagen C-terminal domain. Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1 alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.","GO:0001501|skeletal system development;GO:0001649|osteoblast differentiation;GO:0001894|tissue homeostasis;GO:0002062|chondrocyte differentiation;GO:0007605|sensory perception of sound;GO:0030198|extracellular matrix organization;GO:0030199|collagen fibril organization;GO:0048705|skeletal system morphogenesis;GO:0051216|cartilage development;GO:0060021|roof of mouth development;GO:0060023|soft palate development;","GO:0005575|cellular_component;GO:0005581|collagen trimer;GO:0005615|extracellular space;GO:0031012|extracellular matrix;","GO:0003674|molecular_function;GO:0005201|extracellular matrix structural constituent;","K19721","COL5AS; collagen type V/XI/XXIV/XXVII, alpha"]
["ENSRNOG00000033693",76,6.394280417,6,0.385982629,16.56623883,4.050174187,{"v":3.13e-20,"d":"3.13E-20"},{"v":9.06e-20,"d":"9.06E-20"},"up","yes","AC135826.1","protein_coding","chr2:31507424-31570542:-","gi|564299708|ref|XP_006224055.1|",7483,0,"PREDICTED: baculoviral IAP repeat-containing protein 1b [Rattus norvegicus]","gi|672041330|ref|XM_008760697.1|",3876,0,"PREDICTED: Rattus norvegicus NLR family, apoptosis inhibitory protein 6 (Naip6), transcript variant X5, mRNA","Q9QUK4",2503,0,"Baculoviral IAP repeat-containing protein 1b",".",".",".",".","pfam05729","NACHT","NACHT domain. This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.",".",".",".",".","."]
["ENSRNOG00000016687",319,26.8391507,181,11.64380931,2.30501462,1.204775901,{"v":3.76e-20,"d":"3.76E-20"},{"v":1.09e-19,"d":"1.09E-19"},"up","yes","Ssc5d","protein_coding","chr1:68891949-68909743:-","gi|197386139|ref|NP_001128017.1|",5661,0,"soluble scavenger receptor cysteine-rich domain-containing protein SSC5D precursor [Rattus norvegicus]","gi|197386138|ref|NM_001134545.1|",4495,0,"Rattus norvegicus scavenger receptor cysteine rich family, 5 domains (Ssc5d), mRNA","Q8BV57",1753,0,"Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D",".",".",".",".","pfam00530","SRCR","Scavenger receptor cysteine-rich domain. These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.","GO:0006897|endocytosis;GO:0006952|defense response;GO:0032677|regulation of interleukin-8 production;GO:0032717|negative regulation of interleukin-8 production;GO:0042494|detection of bacterial lipoprotein;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;","GO:0005615|extracellular space;GO:0016020|membrane;GO:0031012|extracellular matrix;GO:0062023|collagen-containing extracellular matrix;","GO:0001968|fibronectin binding;GO:0005044|scavenger receptor activity;GO:0043236|laminin binding;GO:0050840|extracellular matrix binding;",".","."]
["ENSRNOG00000026039",148,12.45201976,47,3.023530595,4.118370683,2.042073689,{"v":4.24e-20,"d":"4.24E-20"},{"v":1.22e-19,"d":"1.22E-19"},"up","yes","Tspan32","protein_coding","chr1:198190164-198204445:+","gi|564298647|ref|XP_002725803.3|",1183,{"v":6E-158,"d":"6.00E-158"},"PREDICTED: tetraspanin-32 isoform X1 [Rattus norvegicus]","gi|672039545|ref|XM_002728846.4|",1514,0,"PREDICTED: Rattus norvegicus pan hematopoietic expression (Phemx), transcript variant X1, mRNA","Q9JHH2",421,{"v":6e-144,"d":"6.00E-144"},"Tetraspanin-32",".",".",".",".","pfam00335","Tetraspannin","Tetraspanin family.","GO:0007010|cytoskeleton organization;GO:0007229|integrin-mediated signaling pathway;GO:0007596|blood coagulation;GO:0007599|hemostasis;GO:0008285|negative regulation of cell proliferation;GO:0030886|negative regulation of myeloid dendritic cell activation;GO:0042832|defense response to protozoan;GO:0050688|regulation of defense response to virus;GO:0051604|protein maturation;GO:0070527|platelet aggregation;GO:0072659|protein localization to plasma membrane;","GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0070442|integrin alphaIIb-beta3 complex;",".","K17359","TSPAN32; tetraspanin-32"]
["ENSRNOG00000023628",390,32.81275477,245,15.76095736,2.08190112,1.057901549,{"v":5.32e-20,"d":"5.32E-20"},1.53E-19,"up","yes","Tmem106a","protein_coding","chr10:86506936-86515892:+","gi|672068485|ref|XP_008766199.1|",1463,0,"PREDICTED: transmembrane protein 106A isoform X1 [Rattus norvegicus]","gi|672068486|ref|XM_008767978.1|",2184,0,"PREDICTED: Rattus norvegicus transmembrane protein 106A (Tmem106a), transcript variant X2, mRNA","Q5BK83",457,{"v":5e-155,"d":"5.00E-155"},"Transmembrane protein 106A",".",".",".",".","pfam07092","DUF1356","Protein of unknown function (DUF1356). This family consists of several hypothetical mammalian proteins of around 250 residues in length. The function of this family is unknown.","GO:0008150|biological_process;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032755|positive regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0035780|CD80 biosynthetic process;GO:0035781|CD86 biosynthetic process;GO:0042116|macrophage activation;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043410|positive regulation of MAPK cascade;GO:0045087|innate immune response;GO:0045348|positive regulation of MHC class II biosynthetic process;GO:1904407|positive regulation of nitric oxide metabolic process;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;","K25049","TMEM106A; transmembrane protein 106A"]
["ENSRNOG00000028259",88,7.403903641,12,0.771965258,9.590980374,3.261678293,{"v":5.48e-20,"d":"5.48E-20"},{"v":1.57e-19,"d":"1.57E-19"},"up","yes","Mcemp1","protein_coding","chr12:1718730-1725986:+","gi|672072052|ref|XP_008767209.1|",1405,0,"PREDICTED: mast cell-expressed membrane protein 1 isoform X1 [Rattus norvegicus]","gi|672072051|ref|XM_008768987.1|",1429,0,"PREDICTED: Rattus norvegicus mast cell-expressed membrane protein 1 (Mcemp1), transcript variant X1, mRNA","Q9D8U6",262,{"v":9e-83,"d":"9.00E-83"},"Mast cell-expressed membrane protein 1",".",".",".",".","pfam03954","Lectin_N","Hepatic lectin, N-terminal domain.",".","GO:0016021|integral component of membrane;","GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000064142",202,16.99532427,86,5.532417684,3.071952488,1.619155903,{"v":5.59e-20,"d":"5.59E-20"},{"v":1.6e-19,"d":"1.60E-19"},"up","yes","ENSRNOG00000064142","lncRNA","chr11:42908366-42909428:+","gi|149060312|gb|EDM11026.1|",184,{"v":2E-14,"d":"2.00E-14"},"rCG52582 [Rattus norvegicus]","gi|26081939|dbj|AK030674.1|",683,0,"Mus musculus 6 days neonate head cDNA, RIKEN full-length enriched library, clone:5430419M07 product:unclassifiable, full insert sequence",".",".",".",".",".",".",".",".","pfam15573","Imm27","Immunity protein 27. A predicted immunity protein with an alpha+beta fold and a conserved KxGDxxK motif. Proteins containing this domain are present in heterogeneous polyimmunity loci in polymorphic toxin systems.",".",".",".",".","."]
["ENSRNOG00000017803",166,13.9664546,60,3.859826291,3.618415323,1.85535801,{"v":7.14e-20,"d":"7.14E-20"},2.03E-19,"up","yes","Apbb1ip","protein_coding","chr17:84982243-85033010:+","gi|281332190|ref|NP_001094047.1|",2357,0,"amyloid beta A4 precursor protein-binding family B member 1-interacting protein [Rattus norvegicus]","gi|281332189|ref|NM_001100577.1|",2455,0,"Rattus norvegicus amyloid beta precursor protein binding family B member 1 interacting protein (Apbb1ip), mRNA","Q8R5A3",649,0,"Amyloid beta A4 precursor protein-binding family B member 1-interacting protein",".",".",".",".","pfam00788","RA","Ras association (RalGDS/AF-6) domain. RasGTP effectors (in cases of AF6, canoe and RalGDS); putative RasGTP effectors in other cases. Recent evidence (not yet in MEDLINE) shows that some RA domains do NOT bind RasGTP. Predicted structure similar to that determined, and that of the RasGTP-binding domain of Raf kinase.","GO:0002291|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0007165|signal transduction;GO:0045785|positive regulation of cell adhesion;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0042101|T cell receptor complex;",".","K17704","APBB1IP, RIAM; amyloid beta A4 precursor protein-binding family B member 1-interacting protein"]
["ENSRNOG00000013862",93,7.824579984,15,0.964956573,8.108737952,3.01947739,1.03E-19,{"v":2.92e-19,"d":"2.92E-19"},"up","yes","Dusp2","protein_coding","chr3:114556325-114558499:+","gi|58865748|ref|NP_001012089.1|",1420,0,"dual specificity protein phosphatase 2 [Rattus norvegicus]","gi|58865747|ref|NM_001012089.1|",1623,0,"Rattus norvegicus dual specificity phosphatase 2 (Dusp2), mRNA","Q05922",536,0,"Dual specificity protein phosphatase 2","SPBC17A3.06",74.3,{"v":1E-13,"d":"1.00E-13"},"COG2453","pfam00782","DSPc","Dual specificity phosphatase, catalytic domain. Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a \"recognition\" region.","GO:0001706|endoderm formation;GO:0006470|protein dephosphorylation;GO:0043409|negative regulation of MAPK cascade;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0031965|nuclear membrane;","GO:0004721|phosphoprotein phosphatase activity;GO:0004725|protein tyrosine phosphatase activity;GO:0008330|protein tyrosine/threonine phosphatase activity;GO:0017017|MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0051019|mitogen-activated protein kinase binding;","K04459","DUSP, MKP; dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48]"]
["ENSRNOG00000058329",230,19.35111179,109,7.012017762,2.759706613,1.464514901,1.16E-19,{"v":3.27e-19,"d":"3.27E-19"},"up","yes","Prrx2","protein_coding","chr3:14094004-14168535:+","gi|157787036|ref|NP_001099209.1|",693,{"v":1E-84,"d":"1.00E-84"},"paired mesoderm homeobox protein 2 [Rattus norvegicus]","gi|157787035|ref|NM_001105739.1|",1215,0,"Rattus norvegicus paired related homeobox 2 (Prrx2), mRNA","Q99811",266,{"v":3e-84,"d":"3.00E-84"},"Paired mesoderm homeobox protein 2","ECU03g1170",50.8,{"v":2e-06,"d":"2.00E-06"},"COG5576","pfam00046","Homeobox","Homeobox domain.","GO:0002053|positive regulation of mesenchymal cell proliferation;GO:0006357|regulation of transcription by RNA polymerase II;GO:0030326|embryonic limb morphogenesis;GO:0042472|inner ear morphogenesis;GO:0042474|middle ear morphogenesis;GO:0045880|positive regulation of smoothened signaling pathway;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048701|embryonic cranial skeleton morphogenesis;GO:0048704|embryonic skeletal system morphogenesis;GO:0048844|artery morphogenesis;GO:0051216|cartilage development;","GO:0005634|nucleus;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0071837|HMG box domain binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09329","PRRX, PMX; paired mesoderm homeobox protein"]
["ENSRNOG00000001216",132,11.10585546,38,2.444556651,4.543095967,2.183675781,{"v":1.46e-19,"d":"1.46E-19"},4.09E-19,"up","yes","Trpm2","protein_coding","chr20:10707014-10753181:+","gi|564397367|ref|XP_006256310.1|",7426,0,"PREDICTED: transient receptor potential cation channel subfamily M member 2 isoform X1 [Rattus norvegicus]","gi|672085964|ref|XM_006256248.2|",5387,0,"PREDICTED: Rattus norvegicus transient receptor potential cation channel, subfamily M, member 2 (Trpm2), transcript variant X1, mRNA","E9PTA2",2849,0,"Transient receptor potential cation channel subfamily M member 2",".",".",".",".","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0001659|temperature homeostasis;GO:0002407|dendritic cell chemotaxis;GO:0006828|manganese ion transport;GO:0009408|response to heat;GO:0014074|response to purine-containing compound;GO:0032024|positive regulation of insulin secretion;GO:0033194|response to hydroperoxide;GO:0035584|calcium-mediated signaling using intracellular calcium source;GO:0035725|sodium ion transmembrane transport;GO:0044849|estrous cycle;GO:0051209|release of sequestered calcium ion into cytosol;GO:0051289|protein homotetramerization;GO:0051489|regulation of filopodium assembly;GO:0070301|cellular response to hydrogen peroxide;GO:0070588|calcium ion transmembrane transport;GO:0071277|cellular response to calcium ion;GO:0071415|cellular response to purine-containing compound;GO:0071421|manganese ion transmembrane transport;GO:0071502|cellular response to temperature stimulus;GO:0071577|zinc ion transmembrane transport;GO:0097028|dendritic cell differentiation;GO:0097553|calcium ion transmembrane import into cytosol;GO:0098655|cation transmembrane transport;GO:0098703|calcium ion import across plasma membrane;GO:1903223|positive regulation of oxidative stress-induced neuron death;GO:2000249|regulation of actin cytoskeleton reorganization;","GO:0005764|lysosome;GO:0005765|lysosomal membrane;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0030659|cytoplasmic vesicle membrane;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043204|perikaryon;","GO:0003674|molecular_function;GO:0005261|cation channel activity;GO:0005272|sodium channel activity;GO:0005384|manganese ion transmembrane transporter activity;GO:0005509|calcium ion binding;GO:0015278|calcium-release channel activity;GO:0072571|mono-ADP-D-ribose binding;GO:0099604|ligand-gated calcium channel activity;","K04977","TRPM2; transient receptor potential cation channel subfamily M member 2 [EC:3.6.1.13]"]
["ENSRNOG00000026644",375,31.55072574,234,15.05332254,2.095931026,1.067591241,1.48E-19,{"v":4.13e-19,"d":"4.13E-19"},"up","yes","Glipr1","protein_coding","chr7:47487345-47498429:-","gi|58865542|ref|NP_001011987.1|",1240,{"v":7e-169,"d":"7.00E-169"},"glioma pathogenesis-related protein 1 precursor [Rattus norvegicus]","gi|298881279|emb|FQ229810.1|",1036,0,"Rattus norvegicus TL0ADA46YJ18 mRNA sequence","Q9CWG1",377,{"v":5e-129,"d":"5.00E-129"},"Glioma pathogenesis-related protein 1","YJL079c",64.7,{"v":6E-11,"d":"6.00E-11"},"COG2340","pfam00188","CAP","Cysteine-rich secretory protein family. This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organisms, including prokaryotes and non-vertebrate eukaryotes, The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumor suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilisation. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The Ca++-chelating function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how helothermine from Heloderma horridum horridum blocks the Ca++ transporting ryanodine receptors.",".","GO:0005615|extracellular space;GO:0016021|integral component of membrane;",".","K24834","GLIPR1; glioma pathogenesis-related protein 1"]
["ENSRNOG00000065206",66,5.552927731,1,0.064330438,86.31882336,6.431603294,1.79E-19,{"v":5e-19,"d":"5.00E-19"},"up","yes","ENSRNOG00000065206","protein_coding","chr1:122867221-122869344:+","gi|672059154|ref|XP_008763709.1|",2906,0,"PREDICTED: MLV-related proviral Env polyprotein-like [Rattus norvegicus]","gi|672059153|ref|XM_008765487.1|",1623,0,"PREDICTED: Rattus norvegicus MLV-related proviral Env polyprotein-like (LOC102551832), mRNA","P21415",489,{"v":6e-163,"d":"6.00E-163"},"Envelope glycoprotein",".",".",".",".","pfam00429","TLV_coat","ENV polyprotein (coat polyprotein).",".",".",".",".","."]
["ENSRNOG00000001270",182,15.31261889,73,4.696121987,3.260694448,1.705179256,{"v":2E-19,"d":"2.00E-19"},{"v":5.58e-19,"d":"5.58E-19"},"up","yes","Hvcn1","protein_coding","chr12:34335190-34370141:-","gi|564315319|ref|XP_006221413.1|",1175,{"v":7e-146,"d":"7.00E-146"},"PREDICTED: voltage-gated hydrogen channel 1 isoform X2 [Rattus norvegicus]","gi|672026745|ref|XM_006221351.2|",1882,0,"PREDICTED: Rattus norvegicus hydrogen voltage-gated channel 1 (Hvcn1), transcript variant X2, mRNA","Q3U2S8",399,{"v":3e-126,"d":"3.00E-126"},"Voltage-gated hydrogen channel 1",".",".",".",".","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0009268|response to pH;GO:0010043|response to zinc ion;GO:0032930|positive regulation of superoxide anion generation;GO:0051453|regulation of intracellular pH;GO:0071294|cellular response to zinc ion;GO:0071467|cellular response to pH;GO:1902600|proton transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;","GO:0022843|voltage-gated cation channel activity;GO:0030171|voltage-gated proton channel activity;GO:0042802|identical protein binding;","K22644","HVCN1, HV1; voltage-gated hydrogen channel 1"]
["ENSRNOG00000015366",125,10.51690858,34,2.187234898,4.808312353,2.265530618,2.14E-19,{"v":5.95e-19,"d":"5.95E-19"},"up","yes","Neurl3","protein_coding","chr9:38494489-38502649:-","gi|62078933|ref|NP_001014122.1|",1346,0,"E3 ubiquitin-protein ligase NEURL3 [Rattus norvegicus]","gi|298891378|emb|FQ227363.1|",1424,0,"Rattus norvegicus TL0AEA13YJ20 mRNA sequence","Q5M870",523,0,"E3 ubiquitin-protein ligase NEURL3",".",".",".",".","pfam07177","Neuralized","Neuralized. This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.","GO:0016567|protein ubiquitination;",".","GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;","K15689","NEURL3, LINCR; E3 ubiquitin-protein ligase NEURL3 [EC:2.3.2.27]"]
["ENSRNOG00000016812",101,8.497662133,20,1.286608764,6.604697848,2.723492563,{"v":2.49e-19,"d":"2.49E-19"},{"v":6.91e-19,"d":"6.91E-19"},"up","yes","Adamts16","protein_coding","chr1:32430436-32560494:+","gi|392334541|ref|XP_003753205.1|",6119,0,"PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 16 isoform X1 [Rattus norvegicus]","gi|672012606|ref|XM_003753157.3|",4976,0,"PREDICTED: Rattus norvegicus ADAM metallopeptidase with thrombospondin type 1 motif, 16 (Adamts16), transcript variant X1, mRNA","Q69Z28",2187,0,"A disintegrin and metalloproteinase with thrombospondin motifs 16",".",".",".",".","pfam05986","ADAM_spacer1","ADAM-TS Spacer 1. This family represents the Spacer-1 region from the ADAM-TS family of metalloproteinases.","GO:0001658|branching involved in ureteric bud morphogenesis;GO:0003073|regulation of systemic arterial blood pressure;GO:0006508|proteolysis;GO:0030198|extracellular matrix organization;GO:0048232|male gamete generation;GO:1902017|regulation of cilium assembly;","GO:0005576|extracellular region;GO:0031012|extracellular matrix;","GO:0004222|metalloendopeptidase activity;GO:0046872|metal ion binding;","K08630","ADAMTS16; a disintegrin and metalloproteinase with thrombospondin motifs 16 [EC:3.4.24.-]"]
["ENSRNOG00000023428",166,13.9664546,63,4.052817606,3.446109831,1.784968683,{"v":6.28e-19,"d":"6.28E-19"},1.71E-18,"up","yes","Pik3r5","protein_coding","chr10:53132603-53199374:+","gi|300794017|ref|NP_001178852.1|",4266,0,"phosphoinositide 3-kinase regulatory subunit 5 [Rattus norvegicus]","gi|672067999|ref|XM_006246770.2|",3176,0,"PREDICTED: Rattus norvegicus phosphoinositide-3-kinase, regulatory subunit 5 (Pik3r5), transcript variant X1, mRNA","Q5SW28",1546,0,"Phosphoinositide 3-kinase regulatory subunit 5",".",".",".",".","pfam10486","PI3K_1B_p101","Phosphoinositide 3-kinase gamma adapter protein p101 subunit. Class I PI3Ks are dual-specific lipid and protein kinases involved in numerous intracellular signaling pathways. Class IB PI3K, p110gamma, is mainly activated by seven-transmembrane G-protein-coupled receptors (GPCRs), through its regulatory subunit p101 and G-protein beta-gamma subunits.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0014065|phosphatidylinositol 3-kinase signaling;GO:0043406|positive regulation of MAP kinase activity;GO:0043551|regulation of phosphatidylinositol 3-kinase activity;GO:0051897|positive regulation of protein kinase B signaling;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005942|phosphatidylinositol 3-kinase complex;GO:0005944|phosphatidylinositol 3-kinase complex, class IB;GO:0016020|membrane;GO:0034451|centriolar satellite;","GO:0031683|G-protein beta/gamma-subunit complex binding;GO:0046935|1-phosphatidylinositol-3-kinase regulator activity;","K21290","PIK3R5_6; phosphoinositide-3-kinase regulatory subunit 5/6"]
["ENSRNOG00000071032",80,6.730821492,10,0.643304382,10.46288768,3.387209175,{"v":7.38e-19,"d":"7.38E-19"},{"v":2e-18,"d":"2.00E-18"},"up","yes","Mmp25","protein_coding","chr10:12661208-12675871:-","gi|293339906|ref|XP_001055465.2|",2777,0,"PREDICTED: matrix metalloproteinase-25 isoform X1 [Rattus norvegicus]","gi|672024565|ref|XM_001055465.4|",3146,0,"PREDICTED: Rattus norvegicus matrix metallopeptidase 25 (Mmp25), transcript variant X1, mRNA","Q3U435",918,0,"Matrix metalloproteinase-25",".",".",".",".","pfam00413","Peptidase_M10","Matrixin. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.",".",".",".",".","."]
["ENSRNOG00000018092",315,26.50260962,185,11.90113106,2.226898391,1.155035733,{"v":9.97e-19,"d":"9.97E-19"},{"v":2.69e-18,"d":"2.69E-18"},"up","yes","Cd83","protein_coding","chr17:20887309-20907083:-","gi|157822369|ref|NP_001101880.1|",919,{"v":2E-116,"d":"2.00E-116"},"CD83 antigen precursor [Rattus norvegicus]","gi|157822368|ref|NM_001108410.1|",2119,0,"Rattus norvegicus CD83 molecule (Cd83), mRNA","O88324",340,{"v":1e-110,"d":"1.00E-110"},"CD83 antigen",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0014070|response to organic cyclic compound;GO:0032713|negative regulation of interleukin-4 production;GO:0032733|positive regulation of interleukin-10 production;GO:0032743|positive regulation of interleukin-2 production;GO:0043372|positive regulation of CD4-positive, alpha-beta T cell differentiation;","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;",".","K06510","CD83; CD83 antigen"]
["ENSRNOG00000012562",220,18.5097591,105,6.754696009,2.740280107,1.454323371,{"v":1.07e-18,"d":"1.07E-18"},2.89E-18,"up","yes","Grin3b","protein_coding","chr7:9730862-9737183:-","gi|20376816|ref|NP_579842.2|",4417,0,"glutamate receptor ionotropic, NMDA 3B precursor [Rattus norvegicus]","gi|20376815|ref|NM_133308.2|",3151,0,"Rattus norvegicus glutamate ionotropic receptor NMDA type subunit 3B (Grin3b), mRNA","Q8VHN2",1706,0,"Glutamate receptor ionotropic, NMDA 3B",".",".",".",".","pfam00060","Lig_chan","Ligand-gated ion channel. This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.","GO:0035235|ionotropic glutamate receptor signaling pathway;GO:0051205|protein insertion into membrane;GO:0051924|regulation of calcium ion transport;GO:0070588|calcium ion transmembrane transport;","GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0017146|NMDA selective glutamate receptor complex;GO:0043025|neuronal cell body;GO:0045211|postsynaptic membrane;GO:0098686|hippocampal mossy fiber to CA3 synapse;GO:0099061|integral component of postsynaptic density membrane;","GO:0004970|ionotropic glutamate receptor activity;GO:0004972|NMDA glutamate receptor activity;GO:0005261|cation channel activity;GO:0005262|calcium channel activity;GO:0015276|ligand-gated ion channel activity;GO:0016594|glycine binding;GO:0030594|neurotransmitter receptor activity;GO:0038023|signaling receptor activity;GO:0042165|neurotransmitter binding;","K05214","GRIN3B; glutamate receptor ionotropic, NMDA 3B"]
["ENSRNOG00000013572",283,23.81028103,158,10.16420923,2.342561087,1.228086669,{"v":1.47e-18,"d":"1.47E-18"},3.91E-18,"up","yes","Lxn","protein_coding","chr2:151727102-151733460:-","gi|14269568|ref|NP_113843.1|",1211,{"v":3E-162,"d":"3.00E-162"},"latexin [Rattus norvegicus]","gi|298888579|emb|FQ220594.1|",1088,0,"Rattus norvegicus TL0ADA42YF08 mRNA sequence","Q64361",471,{"v":9e-164,"d":"9.00E-164"},"Latexin",".",".",".",".","pfam06907","Latexin","Latexin. This family consists of several animal specific latexin proteins. Latexin is a carboxypeptidase A inhibitor and is expressed in a cell type-specific manner in both central and peripheral nervous systems in the rat.","GO:0006954|inflammatory response;GO:0010951|negative regulation of endopeptidase activity;GO:0050965|detection of temperature stimulus involved in sensory perception of pain;","GO:0005615|extracellular space;GO:0005737|cytoplasm;","GO:0008191|metalloendopeptidase inhibitor activity;GO:0008201|heparin binding;","K23594","LXN; latexin"]
["ENSRNOG00000014258",276,23.22133415,152,9.778226604,2.374800164,1.247806118,{"v":1.47e-18,"d":"1.47E-18"},3.91E-18,"up","yes","Rab32","lncRNA","chr1:4945036-4960934:-","gi|157820973|ref|NP_001102372.1|",864,{"v":3E-102,"d":"3.00E-102"},"ras-related protein Rab-32 [Rattus norvegicus]","gi|157820972|ref|NM_001108902.1|",1406,0,"Rattus norvegicus RAB32, member RAS oncogene family (Rab32), mRNA","Q9CZE3",322,{"v":2e-98,"d":"2.00E-98"},"Ras-related protein Rab-32",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0006886|intracellular protein transport;GO:0007005|mitochondrion organization;GO:0016192|vesicle-mediated transport;GO:0019882|antigen processing and presentation;GO:0032438|melanosome organization;GO:0035646|endosome to melanosome transport;GO:0072657|protein localization to membrane;GO:0090382|phagosome maturation;GO:1903232|melanosome assembly;","GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0005769|early endosome;GO:0005783|endoplasmic reticulum;GO:0005802|trans-Golgi network;GO:0012505|endomembrane system;GO:0016020|membrane;GO:0033162|melanosome membrane;GO:0042470|melanosome;GO:0044233|Mitochondria-associated ER Membrane;GO:0045335|phagocytic vesicle;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0030742|GTP-dependent protein binding;GO:0035650|AP-1 adaptor complex binding;GO:0035651|AP-3 adaptor complex binding;GO:0036461|BLOC-2 complex binding;","K07918","RAB32; Ras-related protein Rab-32"]
["ENSRNOG00000042133",62,5.216386656,2,0.128660876,40.54368976,5.341405485,{"v":1.7E-18,"d":"1.70E-18"},{"v":4.52e-18,"d":"4.52E-18"},"up","yes","AABR07006275.1","protein_coding","chr1:208218000-208236257:+","gi|672014684|ref|XP_008772999.1|",1034,{"v":2e-138,"d":"2.00E-138"},"PREDICTED: LOW QUALITY PROTEIN: membrane-spanning 4-domains subfamily A member 4D-like [Rattus norvegicus]","gi|672014683|ref|XM_008774777.1|",1012,0,"PREDICTED: Rattus norvegicus similar to membrane-spanning 4-domains, subfamily A, member 4C (LOC690862), mRNA","Q99N05",283,{"v":4e-93,"d":"4.00E-93"},"Membrane-spanning 4-domains subfamily A member 4D",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.",".",".",".",".","."]
["ENSRNOG00000068415",66,5.552927731,0,0.032165219,172.6376467,7.431603294,{"v":1.8e-18,"d":"1.80E-18"},{"v":4.75e-18,"d":"4.75E-18"},"up","yes","Lrrc15","protein_coding","chr11:70469804-70484267:+","gi|564377191|ref|XP_006248544.1|",2584,0,"PREDICTED: leucine-rich repeat-containing protein 15 isoform X1 [Rattus norvegicus]","gi|672071373|ref|XM_006248482.2|",2068,0,"PREDICTED: Rattus norvegicus leucine rich repeat containing 15 (Lrrc15), transcript variant X1, mRNA","Q8R5M3",994,0,"Leucine-rich repeat-containing protein 15","alr0124_1",88.6,{"v":4e-17,"d":"4.00E-17"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.",".",".",".",".","."]
["ENSRNOG00000030012",92,7.740444715,17,1.093617449,7.077835784,2.82330829,{"v":2.3e-18,"d":"2.30E-18"},{"v":6.07e-18,"d":"6.07E-18"},"up","yes","Clec4a2","protein_coding","chr4:156262692-156321392:+","gi|45758796|gb|AAS76657.1|",1177,{"v":4e-161,"d":"4.00E-161"},"dendritic cell inhibitory receptor 2 [Rattus norvegicus]","gi|45758795|gb|AY494061.1|",790,0,"Rattus norvegicus strain DA dendritic cell inhibitory receptor 2 (Dcir2) mRNA, complete cds","Q67EQ0",293,{"v":6E-98,"d":"6.00E-98"},"C-type lectin domain family 4 member A",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type",".",".","GO:0030246|carbohydrate binding;","K10057","CLEC4A, CD367; C-type lectin domain family 4 member A"]
["ENSRNOG00000065225",136,11.44239654,44,2.83053928,4.042479331,2.015240397,{"v":2.63e-18,"d":"2.63E-18"},{"v":6.9e-18,"d":"6.90E-18"},"up","yes","ENSRNOG00000065225","lncRNA","chr10:54918137-54926637:+",".",".",".",".","gi|354794370|gb|JN958871.1|",96,{"v":6e-41,"d":"6.00E-41"},"Mus musculus targeted deletion, lacZ-tagged mutant allele Slc16a11:tm1(KOMP)Ucd; transgenic",".",".",".",".",".",".",".",".","pfam06978","POP1","Ribonucleases P/MRP protein subunit POP1. This family represents a conserved region approximately 150 residues long located towards the N-terminus of the POP1 subunit that is common to both the RNase MRP and RNase P ribonucleoproteins (EC:3.1.26.5). These RNA-containing enzymes generate mature tRNA molecules by cleaving their 5' ends.",".",".",".",".","."]
["ENSRNOG00000020622",295,24.81990425,170,10.93617449,2.269523431,1.182389383,{"v":3e-18,"d":"3.00E-18"},7.82E-18,"up","yes","Cilp2","protein_coding","chr16:19539706-19547191:+","gi|157822257|ref|NP_001100777.1|",5683,0,"cartilage intermediate layer protein 2 precursor [Rattus norvegicus]","gi|157822256|ref|NM_001107307.1|",4081,0,"Rattus norvegicus cartilage intermediate layer protein 2 (Cilp2), mRNA","D3Z7H8",2004,0,"Cartilage intermediate layer protein 2",".",".",".",".","pfam13330","Mucin2_WxxW","Mucin-2 protein WxxW repeating region. This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in a member from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.","GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0003674|molecular_function;","K24436","CILP; cartilage intermediate layer protein"]
["ENSRNOG00000018659",296,24.90403952,171,11.00050493,2.263899674,1.178810025,{"v":3.17e-18,"d":"3.17E-18"},8.25E-18,"up","yes","Csf1","protein_coding","chr2:195377215-195411704:-","gi|28201782|sp|Q8JZQ0.1|CSF1_RAT",2679,0,"RecName: Full=Macrophage colony-stimulating factor 1; Short=CSF-1; Short=MCSF; Contains: RecName: Full=Processed macrophage colony-stimulating factor 1; Flags: Precursor","gi|22255877|gb|AF515736.1|",2103,0,"Rattus norvegicus colony stimulating factor-1 (Csf1) mRNA, complete cds","Q8JZQ0",1037,0,"Macrophage colony-stimulating factor 1",".",".",".",".","pfam05337","CSF-1","Macrophage colony stimulating factor-1 (CSF-1). Colony stimulating factor 1 (CSF-1) is a homodimeric polypeptide growth factor whose primary function is to regulate the survival, proliferation, differentiation, and function of cells of the mononuclear phagocytic lineage. This lineage includes mononuclear phagocytic precursors, blood monocytes, tissue macrophages, osteoclasts, and microglia of the brain, all of which possess cell surface receptors for CSF-1. The protein has also been linked with male fertility and mutations in the Csf-1 gene have been found to cause osteopetrosis and failure of tooth eruption.","GO:0001503|ossification;GO:0001954|positive regulation of cell-matrix adhesion;GO:0002158|osteoclast proliferation;GO:0002931|response to ischemia;GO:0003006|developmental process involved in reproduction;GO:0006954|inflammatory response;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0008283|cell proliferation;GO:0008284|positive regulation of cell proliferation;GO:0010628|positive regulation of gene expression;GO:0010744|positive regulation of macrophage derived foam cell differentiation;GO:0010759|positive regulation of macrophage chemotaxis;GO:0030225|macrophage differentiation;GO:0030278|regulation of ossification;GO:0030316|osteoclast differentiation;GO:0030335|positive regulation of cell migration;GO:0032270|positive regulation of cellular protein metabolic process;GO:0032946|positive regulation of mononuclear cell proliferation;GO:0038145|macrophage colony-stimulating factor signaling pathway;GO:0040018|positive regulation of multicellular organism growth;GO:0042476|odontogenesis;GO:0042488|positive regulation of odontogenesis of dentin-containing tooth;GO:0045087|innate immune response;GO:0045651|positive regulation of macrophage differentiation;GO:0045657|positive regulation of monocyte differentiation;GO:0045672|positive regulation of osteoclast differentiation;GO:0045860|positive regulation of protein kinase activity;GO:0046579|positive regulation of Ras protein signal transduction;GO:0048873|homeostasis of number of cells within a tissue;GO:0060444|branching involved in mammary gland duct morphogenesis;GO:0060611|mammary gland fat development;GO:0060763|mammary duct terminal end bud growth;GO:0061518|microglial cell proliferation;GO:1901215|negative regulation of neuron death;GO:1902228|positive regulation of macrophage colony-stimulating factor signaling pathway;GO:1904141|positive regulation of microglial cell migration;GO:1905523|positive regulation of macrophage migration;","GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0016604|nuclear body;GO:0048471|perinuclear region of cytoplasm;GO:1990682|CSF1-CSF1R complex;","GO:0005125|cytokine activity;GO:0005157|macrophage colony-stimulating factor receptor binding;GO:0008083|growth factor activity;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;","K05453","CSF1, MCSF; macrophage colony-stimulating factor 1"]
["ENSRNOG00000064984",274,23.05306361,153,9.842557042,2.342182373,1.227853415,{"v":5.15e-18,"d":"5.15E-18"},{"v":1.32e-17,"d":"1.32E-17"},"up","yes","Plscr2","protein_coding","chr8:92808398-92845932:+","gi|149018896|gb|EDL77537.1|",1522,0,"rCG25051 [Rattus norvegicus]","gi|672062711|ref|XM_008766450.1|",1586,0,"PREDICTED: Rattus norvegicus phospholipid scramblase 2 (Plscr2), transcript variant X1, mRNA","Q9DCW2",549,0,"Phospholipid scramblase 2",".",".",".",".","pfam03803","Scramblase","Scramblase. Scramblase is palmitoylated and contains a potential protein kinase C phosphorylation site. Scramblase exhibits Ca2+-activated phospholipid scrambling activity in vitro. There are also possible SH3 and WW binding motifs. Scramblase is involved in the redistribution of phospholipids after cell activation or injury.",".",".",".",".","."]
["ENSRNOG00000003305",77,6.478415686,10,0.643304382,10.07052939,3.332067621,{"v":5.54e-18,"d":"5.54E-18"},{"v":1.42e-17,"d":"1.42E-17"},"up","yes","Cxcr3","protein_coding","chrX:66844318-66846969:-","gi|16758152|ref|NP_445867.1|",1397,0,"C-X-C chemokine receptor type 3 [Rattus norvegicus]","gi|16758151|ref|NM_053415.1|",1504,0,"Rattus norvegicus chemokine (C-X-C motif) receptor 3 (Cxcr3), mRNA","Q9JII9",542,0,"C-X-C chemokine receptor type 3",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001525|angiogenesis;GO:0001937|negative regulation of endothelial cell proliferation;GO:0002685|regulation of leukocyte migration;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007166|cell surface receptor signaling pathway;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0008284|positive regulation of cell proliferation;GO:0010818|T cell chemotaxis;GO:0016525|negative regulation of angiogenesis;GO:0019722|calcium-mediated signaling;GO:0030155|regulation of cell adhesion;GO:0045766|positive regulation of angiogenesis;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050921|positive regulation of chemotaxis;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;GO:0060326|cell chemotaxis;GO:0070098|chemokine-mediated signaling pathway;GO:1900118|negative regulation of execution phase of apoptosis;GO:1900119|positive regulation of execution phase of apoptosis;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0016493|C-C chemokine receptor activity;GO:0016494|C-X-C chemokine receptor activity;GO:0019956|chemokine binding;GO:0019957|C-C chemokine binding;GO:0019958|C-X-C chemokine binding;GO:0038023|signaling receptor activity;","K04188","CXCR3, GPR9, CD183; C-X-C chemokine receptor type 3"]
["ENSRNOG00000002540",133,11.18999073,43,2.766208842,4.045244365,2.016226856,{"v":6.01e-18,"d":"6.01E-18"},{"v":1.54e-17,"d":"1.54E-17"},"up","yes","Rhoh","protein_coding","chr14:42337751-42386369:-","gi|61740627|ref|NP_001013448.1|",1024,{"v":3E-124,"d":"3.00E-124"},"rho-related GTP-binding protein RhoH [Rattus norvegicus]","gi|61740626|ref|NM_001013430.1|",1251,0,"Rattus norvegicus ras homolog family member H (Rhoh), mRNA","Q9D3G9",394,{"v":2e-124,"d":"2.00E-124"},"Rho-related GTP-binding protein RhoH","SPAC110.03",156,{"v":3e-41,"d":"3.00E-41"},"COG1100","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0007015|actin filament organization;GO:0007163|establishment or maintenance of cell polarity;GO:0008045|motor neuron axon guidance;GO:0008360|regulation of cell shape;GO:0016601|Rac protein signal transduction;GO:0030031|cell projection assembly;GO:0030217|T cell differentiation;GO:0030865|cortical cytoskeleton organization;GO:0032956|regulation of actin cytoskeleton organization;GO:0043086|negative regulation of catalytic activity;GO:0043124|negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043652|engulfment of apoptotic cell;GO:0045576|mast cell activation;GO:0045582|positive regulation of T cell differentiation;GO:1902622|regulation of neutrophil migration;","GO:0001772|immunological synapse;GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0005938|cell cortex;GO:0031410|cytoplasmic vesicle;GO:0042995|cell projection;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0019210|kinase inhibitor activity;GO:0019901|protein kinase binding;","K07873","RHOH, TTF; Ras homolog gene family, member H"]
["ENSRNOG00000011680",206,17.33186534,97,6.240052504,2.777519152,1.47379686,{"v":6.3e-18,"d":"6.30E-18"},{"v":1.61e-17,"d":"1.61E-17"},"up","yes","Il16","protein_coding","chr1:137617944-137718130:-","gi|672037391|ref|XP_008757821.1|",6054,0,"PREDICTED: pro-interleukin-16 isoform X3 [Rattus norvegicus]","gi|672037390|ref|XM_008759599.1|",4894,0,"PREDICTED: Rattus norvegicus interleukin 16 (Il16), transcript variant X1, mRNA","O54824",2101,0,"Pro-interleukin-16",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.","GO:0007165|signal transduction;GO:0008150|biological_process;GO:0010628|positive regulation of gene expression;GO:0019221|cytokine-mediated signaling pathway;GO:0030595|leukocyte chemotaxis;GO:0032722|positive regulation of chemokine production;GO:0032730|positive regulation of interleukin-1 alpha production;GO:0032735|positive regulation of interleukin-12 production;GO:0032755|positive regulation of interleukin-6 production;GO:0050729|positive regulation of inflammatory response;GO:0050930|induction of positive chemotaxis;GO:0051924|regulation of calcium ion transport;GO:1902565|positive regulation of neutrophil activation;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005925|focal adhesion;GO:0016607|nuclear speck;GO:0090543|Flemming body;","GO:0003674|molecular_function;GO:0005125|cytokine activity;GO:0042609|CD4 receptor binding;","K22628","IL16; interleukin 16"]
["ENSRNOG00000029756",63,5.300521925,0,0.032165219,164.790481,7.364489098,{"v":8.72e-18,"d":"8.72E-18"},{"v":2.22e-17,"d":"2.22E-17"},"up","yes","P2ry13","protein_coding","chr2:143470425-143473434:-","gi|50811827|ref|NP_001002853.1|",1775,0,"P2Y purinoceptor 13 [Rattus norvegicus]","gi|672042351|ref|XM_008760991.1|",2556,0,"PREDICTED: Rattus norvegicus purinergic receptor P2Y, G-protein coupled, 13 (P2ry13), transcript variant X1, mRNA","Q6GUG4",688,0,"P2Y purinoceptor 13",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0007194|negative regulation of adenylate cyclase activity;GO:0035589|G protein-coupled purinergic nucleotide receptor signaling pathway;GO:0071407|cellular response to organic cyclic compound;","GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0045028|G protein-coupled purinergic nucleotide receptor activity;","K08388","P2RY13; P2Y purinoceptor 13"]
["ENSRNOG00000022921",320,26.92328597,196,12.60876588,2.1352832,1.094427425,{"v":1.5E-17,"d":"1.50E-17"},{"v":3.78e-17,"d":"3.78E-17"},"up","yes","Dact2","protein_coding","chr1:55181024-55191096:-","gi|564325484|ref|XP_006228022.1|",3662,0,"PREDICTED: dapper homolog 2 isoform X1 [Rattus norvegicus]","gi|672034429|ref|XM_006227960.2|",2661,0,"PREDICTED: Rattus norvegicus dishevelled-binding antagonist of beta-catenin 2 (Dact2), transcript variant X2, mRNA","Q7TN08",1130,0,"Dapper homolog 2",".",".",".",".","pfam15268","Dapper","Dapper. This is a family of signalling proteins. They act in a diverse range of signaling pathways and have a range of binding partners. They act as homo- and heterodimers.","GO:0002244|hematopoietic progenitor cell differentiation;GO:0003382|epithelial cell morphogenesis;GO:0007162|negative regulation of cell adhesion;GO:0043588|skin development;GO:0072061|inner medullary collecting duct development;GO:1900108|negative regulation of nodal signaling pathway;","GO:0005737|cytoplasm;","GO:0005080|protein kinase C binding;GO:0008013|beta-catenin binding;GO:0051018|protein kinase A binding;GO:0070097|delta-catenin binding;","K22154","DACT; dapper"]
["ENSRNOG00000018488",147,12.36788449,54,3.473843662,3.560288169,1.831994017,{"v":1.69e-17,"d":"1.69E-17"},{"v":4.24e-17,"d":"4.24E-17"},"up","yes","Cd40","protein_coding","chr3:153790449-153805534:+","gi|564344249|ref|XP_006235573.1|",1553,0,"PREDICTED: tumor necrosis factor receptor superfamily member 5 isoform X1 [Rattus norvegicus]","gi|672047962|ref|XM_006235511.2|",1565,0,"PREDICTED: Rattus norvegicus CD40 molecule, TNF receptor superfamily member 5 (Cd40), transcript variant X1, mRNA","P27512",469,{"v":3E-162,"d":"3.00E-162"},"Tumor necrosis factor receptor superfamily member 5",".",".",".",".","pfam00020","TNFR_c6","TNFR/NGFR cysteine-rich region.","GO:0001934|positive regulation of protein phosphorylation;GO:0002637|regulation of immunoglobulin production;GO:0002768|immune response-regulating cell surface receptor signaling pathway;GO:0006874|cellular calcium ion homeostasis;GO:0006954|inflammatory response;GO:0009617|response to bacterium;GO:0019724|B cell mediated immunity;GO:0023035|CD40 signaling pathway;GO:0030890|positive regulation of B cell proliferation;GO:0031667|response to nutrient levels;GO:0032735|positive regulation of interleukin-12 production;GO:0033590|response to cobalamin;GO:0034341|response to interferon-gamma;GO:0035666|TRIF-dependent toll-like receptor signaling pathway;GO:0036018|cellular response to erythropoietin;GO:0042113|B cell activation;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0042832|defense response to protozoan;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043406|positive regulation of MAP kinase activity;GO:0043491|protein kinase B signaling;GO:0043536|positive regulation of blood vessel endothelial cell migration;GO:0043547|positive regulation of GTPase activity;GO:0045766|positive regulation of angiogenesis;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048304|positive regulation of isotype switching to IgG isotypes;GO:0050776|regulation of immune response;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051607|defense response to virus;GO:0071222|cellular response to lipopolysaccharide;GO:0071260|cellular response to mechanical stimulus;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0090037|positive regulation of protein kinase C signaling;GO:1901652|response to peptide;GO:2000353|positive regulation of endothelial cell apoptotic process;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0035631|CD40 receptor complex;GO:0043025|neuronal cell body;GO:0043196|varicosity;GO:0043231|intracellular membrane-bounded organelle;","GO:0003823|antigen binding;GO:0019899|enzyme binding;GO:0019904|protein domain specific binding;GO:0031625|ubiquitin protein ligase binding;GO:0038023|signaling receptor activity;","K03160","TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5"]
["ENSRNOG00000000239",191,16.06983631,87,5.596748122,2.871280958,1.521694507,{"v":1.8E-17,"d":"1.80E-17"},4.52E-17,"up","yes","Ccl7","protein_coding","chr10:67016446-67018303:+","gi|56090537|ref|NP_001007613.1|",447,{"v":1E-52,"d":"1.00E-52"},"C-C motif chemokine 7 precursor [Rattus norvegicus]","gi|56090536|ref|NM_001007612.1|",807,0,"Rattus norvegicus chemokine (C-C motif) ligand 7 (Ccl7), mRNA","Q9QXY8",176,{"v":4e-54,"d":"4.00E-54"},"C-C motif chemokine 7",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0002548|monocyte chemotaxis;GO:0006954|inflammatory response;GO:0007010|cytoskeleton organization;GO:0007186|G protein-coupled receptor signaling pathway;GO:0008360|regulation of cell shape;GO:0010332|response to gamma radiation;GO:0030335|positive regulation of cell migration;GO:0030593|neutrophil chemotaxis;GO:0043547|positive regulation of GTPase activity;GO:0048245|eosinophil chemotaxis;GO:0048247|lymphocyte chemotaxis;GO:0070098|chemokine-mediated signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071361|cellular response to ethanol;GO:2000503|positive regulation of natural killer cell chemotaxis;","GO:0005615|extracellular space;","GO:0008009|chemokine activity;GO:0008201|heparin binding;GO:0031726|CCR1 chemokine receptor binding;GO:0031727|CCR2 chemokine receptor binding;GO:0048020|CCR chemokine receptor binding;","K05509","CCL7; C-C motif chemokine 7"]
["ENSRNOG00000003233",81,6.81495676,13,0.836295696,8.148979828,3.026619459,{"v":2.1e-17,"d":"2.10E-17"},{"v":5.23e-17,"d":"5.23E-17"},"up","yes","Serpinf2","protein_coding","chr10:60272400-60281243:-","gi|564372692|ref|XP_006246737.1|",2236,0,"PREDICTED: alpha-2-antiplasmin isoform X1 [Rattus norvegicus]","gi|564372691|ref|XM_006246675.1|",2223,0,"PREDICTED: Rattus norvegicus serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 (Serpinf2), transcript variant X1, mRNA","Q61247",632,0,"Alpha-2-antiplasmin","all0778",85.9,{"v":7e-17,"d":"7.00E-17"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0002034|regulation of blood vessel diameter by renin-angiotensin;GO:0010033|response to organic substance;GO:0010757|negative regulation of plasminogen activation;GO:0010951|negative regulation of endopeptidase activity;GO:0030199|collagen fibril organization;GO:0032967|positive regulation of collagen biosynthetic process;GO:0045597|positive regulation of cell differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046330|positive regulation of JNK cascade;GO:0048514|blood vessel morphogenesis;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0051496|positive regulation of stress fiber assembly;GO:0051918|negative regulation of fibrinolysis;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071636|positive regulation of transforming growth factor beta production;","GO:0005577|fibrinogen complex;GO:0005615|extracellular space;GO:0009986|cell surface;","GO:0002020|protease binding;GO:0004867|serine-type endopeptidase inhibitor activity;GO:0042803|protein homodimerization activity;","K03983","SERPINF2, AAP; alpha-2-antiplasmin"]
["ENSRNOG00000016595",188,15.81743051,85,5.468087246,2.892680712,1.53240709,{"v":2.2E-17,"d":"2.20E-17"},{"v":5.49e-17,"d":"5.49E-17"},"up","yes","Hhex","protein_coding","chr1:235190455-235196042:+","gi|13242291|ref|NP_077361.1|",948,{"v":1e-121,"d":"1.00E-121"},"hematopoietically-expressed homeobox protein HHEX [Rattus norvegicus]","gi|13242290|ref|NM_024385.1|",1590,0,"Rattus norvegicus hematopoietically expressed homeobox (Hhex), mRNA","P43120",361,{"v":4e-120,"d":"4.00E-120"},"Hematopoietically-expressed homeobox protein Hhex",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001570|vasculogenesis;GO:0001701|in utero embryonic development;GO:0001889|liver development;GO:0002009|morphogenesis of an epithelium;GO:0002573|myeloid leukocyte differentiation;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006406|mRNA export from nucleus;GO:0007165|signal transduction;GO:0007219|Notch signaling pathway;GO:0007492|endoderm development;GO:0009611|response to wounding;GO:0009887|animal organ morphogenesis;GO:0009952|anterior/posterior pattern specification;GO:0016525|negative regulation of angiogenesis;GO:0016973|poly(A)+ mRNA export from nucleus;GO:0022027|interkinetic nuclear migration;GO:0030097|hemopoiesis;GO:0030154|cell differentiation;GO:0030177|positive regulation of Wnt signaling pathway;GO:0030183|B cell differentiation;GO:0030878|thyroid gland development;GO:0030900|forebrain development;GO:0030948|negative regulation of vascular endothelial growth factor receptor signaling pathway;GO:0031016|pancreas development;GO:0034504|protein localization to nucleus;GO:0035050|embryonic heart tube development;GO:0035264|multicellular organism growth;GO:0042127|regulation of cell proliferation;GO:0043434|response to peptide hormone;GO:0045736|negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048568|embryonic organ development;GO:0048729|tissue morphogenesis;GO:0048853|forebrain morphogenesis;GO:0060431|primary lung bud formation;GO:0061009|common bile duct development;GO:0061010|gall bladder development;GO:0061011|hepatic duct development;GO:0061017|hepatoblast differentiation;GO:0070365|hepatocyte differentiation;GO:0070663|regulation of leukocyte proliferation;GO:0071103|DNA conformation change;GO:0090009|primitive streak formation;GO:0090263|positive regulation of canonical Wnt signaling pathway;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0032993|protein-DNA complex;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003682|chromatin binding;GO:0003700|DNA-binding transcription factor activity;GO:0008190|eukaryotic initiation factor 4E binding;GO:0008301|DNA binding, bending;GO:0042803|protein homodimerization activity;GO:0043565|sequence-specific DNA binding;GO:0071837|HMG box domain binding;","K08024","HHEX, HEX, PRH; homeobox protein HEX"]
["ENSRNOG00000031024",61,5.132251387,0,0.032165219,159.5590371,7.317946512,{"v":2.52e-17,"d":"2.52E-17"},{"v":6.28e-17,"d":"6.28E-17"},"up","yes","Sirpd","protein_coding","chr2:85513491-85702289:+","gi|672041746|ref|XP_008759042.1|",1388,0,"PREDICTED: tyrosine-protein phosphatase non-receptor type substrate 1-like isoform X2 [Rattus norvegicus]","gi|672015586|ref|XM_008775108.1|",781,0,"PREDICTED: Rattus norvegicus signal-regulatory protein delta (Sirpd), transcript variant X1, mRNA","P97797",188,{"v":3E-52,"d":"3.00E-52"},"Tyrosine-protein phosphatase non-receptor type substrate 1",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0050766|positive regulation of phagocytosis;GO:0050870|positive regulation of T cell activation;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000028273",127,10.68517912,41,2.637547966,4.051179071,2.018341857,{"v":3.14e-17,"d":"3.14E-17"},{"v":7.79e-17,"d":"7.79E-17"},"up","yes","Tmem150b","protein_coding","chr1:69125710-69141034:+","gi|157818985|ref|NP_001100946.1|",1072,{"v":1e-140,"d":"1.00E-140"},"transmembrane protein 150B [Rattus norvegicus]","gi|157818984|ref|NM_001107476.1|",1667,0,"Rattus norvegicus transmembrane protein 150B (Tmem150b), mRNA","Q8R218",379,{"v":3e-127,"d":"3.00E-127"},"Modulator of macroautophagy TMEM150B",".",".",".",".","pfam10277","Frag1","Frag1/DRAM/Sfk1 family. This family includes Frag1, DRAM and Sfk1 proteins. Frag1 (FGF receptor activating protein 1) is a protein that is conserved from fungi to humans. There are four potential iso-prenylation sites throughout the peptide, viz CILW, CIIW and CIGL. Frag1 is a membrane-spanning protein that is ubiquitously expressed in adult tissues suggesting an important cellular function. Dram is a family of proteins conserved from nematodes to humans with six hydrophobic transmembrane regions and an Endoplasmic Reticulum signal peptide. It is a lysosomal protein that induces macro-autophagy as an effector of p53-mediated death, where p53 is the tumor-suppressor gene that is frequently mutated in cancer. Expression of Dram is stress-induced. This region is also part of a family of small plasma membrane proteins, referred to as Sfk1, that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, thus allowing proper localisation of Stt4p to the actin cytoskeleton.",".","GO:0005887|integral component of plasma membrane;",".","K21846","TMEM150; transmembrane protein 150"]
["ENSRNOG00000065935",119,10.01209697,36,2.315895775,4.323207062,2.112101937,{"v":4e-17,"d":"4.00E-17"},{"v":9.89e-17,"d":"9.89E-17"},"up","yes","Kng2l1","protein_coding","chr11:77909612-78002971:+","gi|149019923|gb|EDL78071.1|",2265,0,"rCG36716, isoform CRA_d [Rattus norvegicus]","gi|80861400|ref|NM_012696.2|",1441,0,"Rattus norvegicus kininogen 1 (Kng1), mRNA","P08934",873,0,"Kininogen-1",".",".",".",".","pfam00031","Cystatin","Cystatin domain. Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 are related to this family but have not been included.",".",".",".",".","."]
["ENSRNOG00000024264",138,11.61066707,49,3.152191471,3.68336352,1.881023787,{"v":4.54e-17,"d":"4.54E-17"},1.12E-16,"up","yes","Amz1","protein_coding","chr12:13891123-13909783:-","gi|114052795|ref|NP_001040557.1|",2368,0,"archaemetzincin-1 [Rattus norvegicus]","gi|672071996|ref|XM_006248933.2|",2333,0,"PREDICTED: Rattus norvegicus archaelysin family metallopeptidase 1 (Amz1), transcript variant X5, mRNA","Q400C9",914,0,"Archaemetzincin-1",".",".",".",".","pfam07998","Peptidase_M54","Peptidase family M54. This is a family of metallopeptidases. Two human proteins have been reported to degrade synthetic substrates and peptides.","GO:0006508|proteolysis;",".","GO:0008237|metallopeptidase activity;GO:0046872|metal ion binding;","K06974","amzA, AMZ2, AMZ1; archaemetzincin [EC:3.4.-.-]"]
["ENSRNOG00000052407",120,10.09623224,37,2.380226213,4.241711222,2.084646405,5.38E-17,1.32E-16,"up","yes","ENSRNOG00000052407","protein_coding","chrX:97722802-97761853:-","gi|56119141|ref|NP_001007799.1|",3414,0,"tyrosine-protein kinase BTK [Rattus norvegicus]","gi|298899306|emb|FQ215667.1|",2434,0,"Rattus norvegicus TL0ACA47YE13 mRNA sequence","P35991",1311,0,"Tyrosine-protein kinase BTK",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001805|positive regulation of type III hypersensitivity;GO:0001812|positive regulation of type I hypersensitivity;GO:0001818|negative regulation of cytokine production;GO:0002344|B cell affinity maturation;GO:0002553|histamine secretion by mast cell;GO:0006468|protein phosphorylation;GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0010033|response to organic substance;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0030889|negative regulation of B cell proliferation;GO:0034614|cellular response to reactive oxygen species;GO:0035556|intracellular signal transduction;GO:0046777|protein autophosphorylation;GO:0048469|cell maturation;GO:0050790|regulation of catalytic activity;GO:0050853|B cell receptor signaling pathway;GO:0071226|cellular response to molecule of fungal origin;GO:0098761|cellular response to interleukin-7;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0031410|cytoplasmic vesicle;GO:0045121|membrane raft;GO:0048471|perinuclear region of cytoplasm;","GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0005524|ATP binding;GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;GO:0016004|phospholipase activator activity;GO:0042802|identical protein binding;GO:0043274|phospholipase binding;GO:0046872|metal ion binding;","K07370","BTK; Bruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2]"]
["ENSRNOG00000063207",350,29.44734403,228,14.66733991,2.007681298,1.005530272,8.74E-17,{"v":2.13e-16,"d":"2.13E-16"},"up","yes","ENSRNOG00000063207","lncRNA","chr10:101905070-101909650:+","gi|149054872|gb|EDM06689.1|",244,{"v":8e-23,"d":"8.00E-23"},"rCG33258, isoform CRA_a [Rattus norvegicus]","gi|672025505|ref|XR_338969.2|",744,0,"PREDICTED: Rattus norvegicus uncharacterized LOC100912247 (LOC100912247), ncRNA",".",".",".",".",".",".",".",".","pfam07183","DUF1403","Protein of unknown function (DUF1403). This family consists of several hypothetical bacterial proteins of around 320 residues in length. Members of this family are mainly found in Rhizobium and Agrobacterium species. The function of this family is unknown.",".",".",".",".","."]
["ENSRNOG00000001079",216,18.17321803,110,7.0763482,2.56816334,1.360736963,8.98E-17,{"v":2.18e-16,"d":"2.18E-16"},"up","yes","Daglb","protein_coding","chr12:11059732-11102154:-","gi|157820071|ref|NP_001100590.1|",3247,0,"sn1-specific diacylglycerol lipase beta [Rattus norvegicus]","gi|157820070|ref|NM_001107120.1|",3019,0,"Rattus norvegicus diacylglycerol lipase, beta (Daglb), mRNA","P0C1S9",1203,0,"Sn1-specific diacylglycerol lipase beta",".",".",".",".","pfam01764","Lipase_3","Lipase (class 3).","GO:0001516|prostaglandin biosynthetic process;GO:0006629|lipid metabolic process;GO:0006690|icosanoid metabolic process;GO:0007216|G protein-coupled glutamate receptor signaling pathway;GO:0007405|neuroblast proliferation;GO:0010898|positive regulation of triglyceride catabolic process;GO:0016042|lipid catabolic process;GO:0019369|arachidonic acid metabolic process;GO:0022008|neurogenesis;GO:0042136|neurotransmitter biosynthetic process;GO:0050727|regulation of inflammatory response;GO:0071926|endocannabinoid signaling pathway;GO:0098921|retrograde trans-synaptic signaling by endocannabinoid;","GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0045211|postsynaptic membrane;","GO:0004806|triglyceride lipase activity;GO:0016298|lipase activity;GO:0046872|metal ion binding;","K13806","DAGL; sn1-specific diacylglycerol lipase [EC:3.1.1.116]"]
["ENSRNOG00000000704",187,15.73329524,87,5.596748122,2.81114942,1.491160139,1.12E-16,{"v":2.71e-16,"d":"2.71E-16"},"up","yes","Cmklr1","protein_coding","chr12:42974410-43028129:+","gi|83035131|ref|NP_071554.2|",1782,0,"chemokine-like receptor 1 [Rattus norvegicus]","gi|672073389|ref|XM_006249505.2|",5932,0,"PREDICTED: Rattus norvegicus chemokine-like receptor 1 (Cmklr1), transcript variant X1, mRNA","O35786",659,0,"Chemokine-like receptor 1",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0002430|complement receptor mediated signaling pathway;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0010759|positive regulation of macrophage chemotaxis;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0032695|negative regulation of interleukin-12 production;GO:0045600|positive regulation of fat cell differentiation;GO:0050848|regulation of calcium-mediated signaling;GO:0120162|positive regulation of cold-induced thermogenesis;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0001637|G protein-coupled chemoattractant receptor activity;GO:0004875|complement receptor activity;GO:0004930|G protein-coupled receptor activity;GO:0097003|adipokinetic hormone receptor activity;GO:0097004|adipokinetic hormone binding;","K04245","CMKLR1; chemokine-like receptor 1"]
["ENSRNOG00000046050",251,21.11795243,140,9.006261346,2.344807864,1.229469712,{"v":1.16e-16,"d":"1.16E-16"},2.79E-16,"up","yes","ENSRNOG00000046050","protein_coding","chr9:1904045-1916187:-","gi|569001579|ref|XP_006524963.1|",3244,0,"PREDICTED: DENN domain-containing protein 1C isoform X3 [Mus musculus]","gi|187281974|ref|NM_001126289.1|",1732,0,"Rattus norvegicus DENN domain containing 1C (Dennd1c), mRNA","Q8CFK6",1245,0,"DENN domain-containing protein 1C",".",".",".",".","pfam02141","DENN","DENN (AEX-3) domain. DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.",".",".",".",".","."]
["ENSRNOG00000013564",193,16.23810685,92,5.918400313,2.74366484,1.456104256,{"v":1.28e-16,"d":"1.28E-16"},{"v":3.08e-16,"d":"3.08E-16"},"up","yes","Dok3","protein_coding","chr17:9109597-9115188:+","gi|157823803|ref|NP_001100806.1|",1790,0,"docking protein 3 [Rattus norvegicus]","gi|74217653|dbj|AK156060.1|",1457,0,"Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830006H02 product:Adaptor protein (Inhibitory adapter molecule DOK3) homolog [Mus musculus], full insert sequence","B2RYG7",694,0,"Docking protein 3",".",".",".",".","pfam02174","IRS","PTB domain (IRS-1 type).","GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007265|Ras protein signal transduction;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;",".","K24036","DOK3; docking protein 3"]
["ENSRNOG00000002820",96,8.07698579,23,1.479600078,5.45889792,2.448609719,1.41E-16,{"v":3.39e-16,"d":"3.39E-16"},"up","yes","ENSRNOG00000002820","protein_coding","chr10:42615555-42623784:+","gi|14389303|ref|NP_113725.1|",1187,{"v":5e-159,"d":"5.00E-159"},"protein RoBo-1 precursor [Rattus norvegicus]","gi|14389302|ref|NM_031537.1|",1455,0,"Rattus norvegicus RoBo-1 (LOC24906), mRNA","O55006",461,{"v":2E-160,"d":"2.00E-160"},"Protein RoBo-1",".",".",".",".","pfam12749","Metallothio_Euk","Eukaryotic metallothionein. This is a family of eukaryotic metallothioneins.","GO:0046849|bone remodeling;","GO:0005576|extracellular region;",".",".","."]
["ENSRNOG00000030212",112,9.423150088,33,2.12290446,4.438800834,2.150169977,1.53E-16,3.67E-16,"up","yes","Cerkl","protein_coding","chr3:64237522-64340675:-","gi|148695295|gb|EDL27242.1|",2372,0,"mCG20062, isoform CRA_b, partial [Mus musculus]","gi|672046046|ref|XR_086195.4|",1797,0,"PREDICTED: Rattus norvegicus ceramide kinase-like (Cerkl), transcript variant X2, misc_RNA","Q49MI3",769,0,"Ceramide kinase-like protein",".",".",".",".","pfam00781","DAGK_cat","Diacylglycerol kinase catalytic domain. Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologues. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.","GO:0008150|biological_process;GO:0016310|phosphorylation;GO:0030148|sphingolipid biosynthetic process;GO:0043066|negative regulation of apoptotic process;GO:0046834|lipid phosphorylation;","GO:0001750|photoreceptor outer segment;GO:0001917|photoreceptor inner segment;GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0048471|perinuclear region of cytoplasm;","GO:0003674|molecular_function;GO:0003951|NAD+ kinase activity;GO:0046625|sphingolipid binding;",".","."]
["ENSRNOG00000006705",127,10.68517912,43,2.766208842,3.862752138,1.949629107,1.56E-16,{"v":3.75e-16,"d":"3.75E-16"},"up","yes","Mkks","protein_coding","chr3:124201877-124220162:-","gi|56605782|ref|NP_001008354.1|",3008,0,"mcKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin [Rattus norvegicus]","gi|558757399|ref|NM_001008353.2|",2953,0,"Rattus norvegicus McKusick-Kaufman syndrome (Mkks), mRNA","Q9JI70",1065,0,"McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin","MTH794",88.6,{"v":3e-17,"d":"3.00E-17"},"COG0459","pfam00118","Cpn60_TCP1","TCP-1/cpn60 chaperonin family. This family includes members from the HSP60 chaperone family and the TCP-1 (T-complex protein) family.","GO:0006457|protein folding;GO:0007286|spermatid development;GO:0007608|sensory perception of smell;GO:0008150|biological_process;GO:0010629|negative regulation of gene expression;GO:0014824|artery smooth muscle contraction;GO:0021756|striatum development;GO:0021766|hippocampus development;GO:0021987|cerebral cortex development;GO:0030837|negative regulation of actin filament polymerization;GO:0032502|developmental process;GO:0033210|leptin-mediated signaling pathway;GO:0034260|negative regulation of GTPase activity;GO:0035176|social behavior;GO:0038108|negative regulation of appetite by leptin-mediated signaling pathway;GO:0040018|positive regulation of multicellular organism growth;GO:0042311|vasodilation;GO:0044321|response to leptin;GO:0045444|fat cell differentiation;GO:0045494|photoreceptor cell maintenance;GO:0045776|negative regulation of blood pressure;GO:0046907|intracellular transport;GO:0048854|brain morphogenesis;GO:0050910|detection of mechanical stimulus involved in sensory perception of sound;GO:0051131|chaperone-mediated protein complex assembly;GO:0051216|cartilage development;GO:0051492|regulation of stress fiber assembly;GO:0060271|cilium assembly;GO:0060296|regulation of cilium beat frequency involved in ciliary motility;GO:0060324|face development;GO:1905515|non-motile cilium assembly;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0031514|motile cilium;GO:0036064|ciliary basal body;GO:1902636|kinociliary basal body;","GO:0003674|molecular_function;GO:0005524|ATP binding;GO:0051082|unfolded protein binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;","K09492","MKKS; McKusick-Kaufman syndrome protein"]
["ENSRNOG00000022884",121,10.18036751,39,2.508887089,4.057722466,2.020670193,1.64E-16,{"v":3.94e-16,"d":"3.94E-16"},"up","yes","Cd84","protein_coding","chr13:84327553-84362076:+","gi|672074825|ref|XP_008767975.1|",1770,0,"PREDICTED: SLAM family member 5 isoform X1 [Rattus norvegicus]","gi|672074824|ref|XM_008769753.1|",1801,0,"PREDICTED: Rattus norvegicus CD84 molecule (Cd84), transcript variant X1, mRNA","Q18PI6",498,{"v":1e-170,"d":"1.00E-170"},"SLAM family member 5",".",".",".",".","pfam00078","RVT_1","Reverse transcriptase (RNA-dependent DNA polymerase). A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs, hepadnaviruses, and caulimoviruses.","GO:0031664|regulation of lipopolysaccharide-mediated signaling pathway;GO:0032685|negative regulation of granulocyte macrophage colony-stimulating factor production;GO:0032693|negative regulation of interleukin-10 production;GO:0032701|negative regulation of interleukin-18 production;GO:0032715|negative regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0033004|negative regulation of mast cell activation;GO:0042110|T cell activation;GO:0043030|regulation of macrophage activation;GO:0043305|negative regulation of mast cell degranulation;GO:0043410|positive regulation of MAPK cascade;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0071639|positive regulation of monocyte chemotactic protein-1 production;GO:2001256|regulation of store-operated calcium entry;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0042802|identical protein binding;","K06511","CD84; CD84 antigen"]
["ENSRNOG00000002188",177,14.89194255,80,5.146435055,2.893642374,1.53288663,{"v":1.83e-16,"d":"1.83E-16"},{"v":4.38e-16,"d":"4.38E-16"},"up","yes","Hpse","protein_coding","chr14:8896593-8937010:+","gi|12018276|ref|NP_072127.1|",2627,0,"heparanase precursor [Rattus norvegicus]","gi|12018275|ref|NM_022605.1|",3134,0,"Rattus norvegicus heparanase (Hpse), mRNA","Q71RP1",1016,0,"Heparanase",".",".",".",".","pfam03662","Glyco_hydro_79n","Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesized as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumor cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity.","GO:0007160|cell-matrix adhesion;GO:0008150|biological_process;GO:0010033|response to organic substance;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0030194|positive regulation of blood coagulation;GO:0030200|heparan sulfate proteoglycan catabolic process;GO:0030202|heparin metabolic process;GO:0033690|positive regulation of osteoblast proliferation;GO:0042060|wound healing;GO:0051797|regulation of hair follicle development;GO:0051798|positive regulation of hair follicle development;GO:0051897|positive regulation of protein kinase B signaling;GO:0060055|angiogenesis involved in wound healing;GO:0061028|establishment of endothelial barrier;GO:0061042|vascular wound healing;GO:0071806|protein transmembrane transport;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005764|lysosome;GO:0005765|lysosomal membrane;GO:0031012|extracellular matrix;GO:0043231|intracellular membrane-bounded organelle;GO:0045121|membrane raft;GO:1904974|heparanase complex;","GO:0030305|heparanase activity;GO:0045545|syndecan binding;","K07964","HPSE; heparanase [EC:3.2.1.166]"]
["ENSRNOG00000011947",116,9.759691163,36,2.315895775,4.214218649,2.075265168,{"v":2.15e-16,"d":"2.15E-16"},{"v":5.1E-16,"d":"5.10E-16"},"up","yes","Tifab","protein_coding","chr17:8431635-8436592:+","gi|68163499|ref|NP_001020200.1|",767,{"v":2E-92,"d":"2.00E-92"},"TRAF-interacting protein with FHA domain-containing protein B [Rattus norvegicus]","gi|672080896|ref|XM_008771443.1|",2890,0,"PREDICTED: Rattus norvegicus TRAF-interacting protein with forkhead-associated domain, family member B (Tifab), transcript variant X1, mRNA","Q5BK67",300,{"v":6e-94,"d":"6.00E-94"},"TRAF-interacting protein with FHA domain-containing protein B",".",".",".",".","pfam00498","FHA","FHA domain. The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.","GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0007356|thorax and anterior abdomen determination;GO:0021559|trigeminal nerve development;GO:0021650|vestibulocochlear nerve formation;GO:0030432|peristalsis;GO:0031223|auditory behavior;GO:0035112|genitalia morphogenesis;GO:0042472|inner ear morphogenesis;GO:0048634|regulation of muscle organ development;GO:0048806|genitalia development;GO:0048839|inner ear development;GO:0050885|neuromuscular process controlling balance;GO:0071626|mastication;GO:0090102|cochlea development;GO:0090103|cochlea morphogenesis;GO:0097094|craniofacial suture morphogenesis;GO:0098583|learned vocalization behavior;GO:1901078|negative regulation of relaxation of muscle;GO:1905747|negative regulation of saliva secretion;GO:1905748|hard palate morphogenesis;",".",".","K23835","TIFB; TRAF-interacting protein with FHA domain-containing protein B"]
["ENSRNOG00000070702",209,17.58427115,106,6.819026448,2.578706987,1.366647852,{"v":2.23e-16,"d":"2.23E-16"},{"v":5.3e-16,"d":"5.30E-16"},"up","yes","Smkr1","protein_coding","chr4:58601660-58609229:+","gi|672018241|ref|XP_008773937.1|",383,{"v":1E-41,"d":"1.00E-41"},"PREDICTED: small lysine-rich protein 1 isoform X1 [Rattus norvegicus]","gi|672018240|ref|XM_008775715.1|",712,0,"PREDICTED: Rattus norvegicus small lysine-rich protein 1 (Smkr1), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam07845","DUF1636","Protein of unknown function (DUF1636). The sequences featured in this family are derived from a number of hypothetical prokaryotic proteins. The region in question is approximately 130 amino acids long.",".",".",".",".","."]
["ENSRNOG00000037476",90,7.572174178,20,1.286608764,5.88537432,2.557134176,{"v":2.4E-16,"d":"2.40E-16"},{"v":5.68e-16,"d":"5.68E-16"},"up","yes","ENSRNOG00000037476","protein_coding","chr12:46050413-46128578:-","gi|169790950|ref|NP_001116116.1|",3156,0,"polypeptide N-acetylgalactosaminyltransferase 9 isoform A [Rattus norvegicus]","gi|169790949|ref|NM_001122644.1|",2858,0,"Rattus norvegicus polypeptide N-acetylgalactosaminyltransferase 9 (Galnt9), transcript variant A, mRNA","Q9HCQ5",1134,0,"Polypeptide N-acetylgalactosaminyltransferase 9","AF0321",54.3,{"v":9e-07,"d":"9.00E-07"},"COG1216","pfam00652","Ricin_B_lectin","Ricin-type beta-trefoil lectin domain.","GO:0006486|protein glycosylation;","GO:0000139|Golgi membrane;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;","GO:0004653|polypeptide N-acetylgalactosaminyltransferase activity;GO:0016740|transferase activity;GO:0030246|carbohydrate binding;GO:0046872|metal ion binding;",".","."]
["ENSRNOG00000054217",323,27.17569177,206,13.25207027,2.050675195,1.036099002,2.55E-16,{"v":6.04e-16,"d":"6.04E-16"},"up","yes","Runx3","protein_coding","chr5:147360994-147419156:+","gi|18426856|ref|NP_569109.1|",2078,0,"runt-related transcription factor 3 [Rattus norvegicus]","gi|298890902|emb|FQ230848.1|",2722,0,"Rattus norvegicus TL0AEA86YB08 mRNA sequence","Q64131",803,0,"Runt-related transcription factor 3",".",".",".",".","pfam00853","Runt","Runt domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001503|ossification;GO:0002062|chondrocyte differentiation;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006468|protein phosphorylation;GO:0007411|axon guidance;GO:0008150|biological_process;GO:0030097|hemopoiesis;GO:0030182|neuron differentiation;GO:0031069|hair follicle morphogenesis;GO:0031175|neuron projection development;GO:0043371|negative regulation of CD4-positive, alpha-beta T cell differentiation;GO:0043378|positive regulation of CD8-positive, alpha-beta T cell differentiation;GO:0045595|regulation of cell differentiation;GO:0045786|negative regulation of cell cycle;GO:0045893|positive regulation of transcription, DNA-templated;GO:0048469|cell maturation;GO:0050680|negative regulation of epithelial cell proliferation;GO:0071559|response to transforming growth factor beta;GO:2001238|positive regulation of extrinsic apoptotic signaling pathway;","GO:0000785|chromatin;GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0043231|intracellular membrane-bounded organelle;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0005524|ATP binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09279","RUNX3, AML2; runt-related transcription factor 3"]
["ENSRNOG00000002826",186,15.64915997,88,5.66107856,2.764342484,1.466936367,{"v":3.11e-16,"d":"3.11E-16"},{"v":7.32e-16,"d":"7.32E-16"},"up","yes","Hsd17b7","protein_coding","chr13:82173179-82190017:-","gi|564381646|ref|XP_006250277.1|",1801,0,"PREDICTED: 3-keto-steroid reductase isoform X1 [Rattus norvegicus]","gi|672074766|ref|XM_006250215.2|",1676,0,"PREDICTED: Rattus norvegicus hydroxysteroid (17-beta) dehydrogenase 7 (Hsd17b7), transcript variant X1, mRNA","Q62904",696,0,"3-keto-steroid reductase",".",".",".",".","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.","GO:0006695|cholesterol biosynthetic process;GO:0006703|estrogen biosynthetic process;GO:0007399|nervous system development;GO:0007420|brain development;GO:0008209|androgen metabolic process;GO:0009410|response to xenobiotic stimulus;GO:0014070|response to organic cyclic compound;GO:0021766|hippocampus development;GO:0030154|cell differentiation;GO:0032355|response to estradiol;GO:0048568|embryonic organ development;GO:0048706|embryonic skeletal system development;GO:0060135|maternal process involved in female pregnancy;GO:1990637|response to prolactin;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0000253|3-keto sterol reductase activity;GO:0004303|estradiol 17-beta-dehydrogenase activity;GO:0005148|prolactin receptor binding;GO:0047024|5alpha-androstane-3beta,17beta-diol dehydrogenase activity;GO:0072582|17-beta-hydroxysteroid dehydrogenase (NADP+) activity;","K13373","HSD17B7; 17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase [EC:1.1.1.62 1.1.1.270]"]
["ENSRNOG00000006860",86,7.235633104,18,1.157947887,6.248669031,2.643548928,{"v":3.25e-16,"d":"3.25E-16"},{"v":7.65e-16,"d":"7.65E-16"},"up","yes","Itk","protein_coding","chr10:30753344-30814685:-","gi|157818821|ref|NP_001102295.1|",3392,0,"tyrosine-protein kinase ITK/TSK [Rattus norvegicus]","gi|672067342|ref|XM_008767692.1|",4199,0,"PREDICTED: Rattus norvegicus IL2-inducible T-cell kinase (Itk), transcript variant X1, mRNA","Q03526",1276,0,"Tyrosine-protein kinase ITK/TSK",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001819|positive regulation of cytokine production;GO:0001865|NK T cell differentiation;GO:0002250|adaptive immune response;GO:0006468|protein phosphorylation;GO:0007202|activation of phospholipase C activity;GO:0035556|intracellular signal transduction;GO:0038083|peptidyl-tyrosine autophosphorylation;GO:0046629|gamma-delta T cell activation;GO:0050852|T cell receptor signaling pathway;GO:0050853|B cell receptor signaling pathway;","GO:0005634|nucleus;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;","GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0005524|ATP binding;GO:0046872|metal ion binding;","K07363","ITK; IL2-inducible T-cell kinase [EC:2.7.10.2]"]
["ENSRNOG00000046452",173,14.55540148,78,5.017774178,2.90076854,1.536435183,3.55E-16,{"v":8.34e-16,"d":"8.34E-16"},"up","yes","Fcgr2b","protein_coding","chr13:83193163-83207778:-","gi|564381693|ref|XP_006250295.1|",1357,{"v":1E-174,"d":"1.00E-174"},"PREDICTED: low affinity immunoglobulin gamma Fc region receptor II-b isoform X1 [Rattus norvegicus]","gi|228480381|gb|AC111734.5|",2522,0,"Rattus norvegicus CH230-184H10 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q63203",456,{"v":1e-149,"d":"1.00E-149"},"Low affinity immunoglobulin gamma Fc region receptor II",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0001811|negative regulation of type I hypersensitivity;GO:0002434|immune complex clearance;GO:0002638|negative regulation of immunoglobulin production;GO:0002862|negative regulation of inflammatory response to antigenic stimulus;GO:0002865|negative regulation of acute inflammatory response to antigenic stimulus;GO:0002924|negative regulation of humoral immune response mediated by circulating immunoglobulin;GO:0006898|receptor-mediated endocytosis;GO:0006911|phagocytosis, engulfment;GO:0006952|defense response;GO:0007166|cell surface receptor signaling pathway;GO:0009617|response to bacterium;GO:0016064|immunoglobulin mediated immune response;GO:0016358|dendrite development;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0021549|cerebellum development;GO:0030889|negative regulation of B cell proliferation;GO:0032355|response to estradiol;GO:0032456|endocytic recycling;GO:0032693|negative regulation of interleukin-10 production;GO:0033030|negative regulation of neutrophil apoptotic process;GO:0038096|Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0046330|positive regulation of JNK cascade;GO:0048169|regulation of long-term neuronal synaptic plasticity;GO:0050765|negative regulation of phagocytosis;GO:0050766|positive regulation of phagocytosis;GO:0050776|regulation of immune response;GO:0050777|negative regulation of immune response;GO:0050859|negative regulation of B cell receptor signaling pathway;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0071219|cellular response to molecule of bacterial origin;GO:0071222|cellular response to lipopolysaccharide;GO:1901216|positive regulation of neuron death;GO:1902950|regulation of dendritic spine maintenance;GO:1904646|cellular response to amyloid-beta;GO:1905898|positive regulation of response to endoplasmic reticulum stress;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0043197|dendritic spine;GO:0044297|cell body;GO:0045121|membrane raft;GO:0055037|recycling endosome;","GO:0001540|amyloid-beta binding;GO:0004888|transmembrane signaling receptor activity;GO:0019772|low-affinity IgG receptor activity;GO:0019864|IgG binding;GO:0019865|immunoglobulin binding;GO:0044877|protein-containing complex binding;","K12560","FCGR2B, CD32; low affinity immunoglobulin gamma Fc receptor II-b"]
["ENSRNOG00000010165",255,21.4544935,146,9.392243975,2.284277704,1.191738053,{"v":3.63e-16,"d":"3.63E-16"},{"v":8.52e-16,"d":"8.52E-16"},"up","yes","Tnfaip2","protein_coding","chr6:130476889-130489914:+","gi|212549631|ref|NP_001131105.1|",3147,0,"tumor necrosis factor alpha-induced protein 2 [Rattus norvegicus]","gi|212549630|ref|NM_001137633.1|",2312,0,"Rattus norvegicus TNF alpha induced protein 2 (Tnfaip2), mRNA","Q61333",1082,0,"Tumor necrosis factor alpha-induced protein 2",".",".",".",".","pfam06046","Sec6","Exocyst complex component Sec6. Sec6 is a component of the multiprotein exocyst complex. Sec6 interacts with Sec8, Sec10 and Exo70.These exocyst proteins localize to regions of active exocytosis-at the growing ends of interphase cells and in the medial region of cells undergoing cytokinesis-in an F-actin-dependent and exocytosis- independent manner.","GO:0006887|exocytosis;GO:0051601|exocyst localization;","GO:0000145|exocyst;","GO:0000149|SNARE binding;","K19989","TNFAIP2, EXOC3L3; tumor necrosis factor alpha-induced protein 2"]
["ENSRNOG00000012208",99,8.329391596,26,1.672591393,4.979932117,2.316126077,{"v":4.58e-16,"d":"4.58E-16"},1.07E-15,"up","yes","Itgb7","protein_coding","chr7:133347960-133364876:-","gi|274320328|ref|NP_037303.1|",3772,0,"integrin beta-7 precursor [Rattus norvegicus]","gi|672059839|ref|XM_006242383.2|",2695,0,"PREDICTED: Rattus norvegicus integrin, beta 7 (Itgb7), transcript variant X1, mRNA","P26011",1361,0,"Integrin beta-7",".",".",".",".","pfam00362","Integrin_beta","Integrin, beta chain. Integrins have been found in animals and their homologues have also been found in cyanobacteria, probably due to horizontal gene transfer. The sequences repeats have been trimmed due to an overlap with EGF.","GO:0003366|cell-matrix adhesion involved in ameboidal cell migration;GO:0007160|cell-matrix adhesion;GO:0007229|integrin-mediated signaling pathway;GO:0016477|cell migration;GO:0033627|cell adhesion mediated by integrin;GO:0034113|heterotypic cell-cell adhesion;GO:0034446|substrate adhesion-dependent cell spreading;GO:0043113|receptor clustering;GO:0050900|leukocyte migration;GO:0050901|leukocyte tethering or rolling;GO:0072678|T cell migration;","GO:0005925|focal adhesion;GO:0008305|integrin complex;GO:0009986|cell surface;GO:0034669|integrin alpha4-beta7 complex;GO:0043235|receptor complex;","GO:0005178|integrin binding;GO:0038023|signaling receptor activity;GO:0050839|cell adhesion molecule binding;","K06590","ITGB7; integrin beta 7"]
["ENSRNOG00000014385",200,16.82705373,100,6.433043818,2.61572192,1.387209175,{"v":4.59e-16,"d":"4.59E-16"},1.07E-15,"up","yes","Wnt2b","protein_coding","chr2:192453824-192470308:-","gi|300797693|ref|NP_001178777.1|",1842,0,"protein Wnt-2b [Rattus norvegicus]","gi|26089811|dbj|AK043566.1|",1108,0,"Mus musculus 10 days neonate cortex cDNA, RIKEN full-length enriched library, clone:A830008G12 product:WNT-2B PROTEIN PRECURSOR (WNT-13), full insert sequence","O70283",703,0,"Protein Wnt-2b",".",".",".",".","pfam00110","wnt","wnt family. Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.","GO:0002062|chondrocyte differentiation;GO:0008150|biological_process;GO:0008584|male gonad development;GO:0009267|cellular response to starvation;GO:0021871|forebrain regionalization;GO:0030182|neuron differentiation;GO:0045165|cell fate commitment;GO:0060070|canonical Wnt signaling pathway;GO:0060492|lung induction;GO:0060638|mesenchymal-epithelial cell signaling;GO:0071425|hematopoietic stem cell proliferation;GO:0090190|positive regulation of branching involved in ureteric bud morphogenesis;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0043231|intracellular membrane-bounded organelle;","GO:0003674|molecular_function;GO:0005109|frizzled binding;GO:0005125|cytokine activity;","K00182","WNT2; wingless-type MMTV integration site family, member 2"]
["ENSRNOG00000023208",332,27.93290919,217,13.95970509,2.000966999,1.000697374,{"v":6.93e-16,"d":"6.93E-16"},{"v":1.6E-15,"d":"1.60E-15"},"up","yes","Myorg","protein_coding","chr5:56648643-56664440:-","gi|157822809|ref|NP_001102441.1|",3603,0,"uncharacterized family 31 glucosidase KIAA1161 homolog [Rattus norvegicus]","gi|672052314|ref|XM_006238094.2|",4714,0,"PREDICTED: Rattus norvegicus similar to KIAA1161 protein (RGD1309821), transcript variant X2, mRNA","Q69ZQ1",1341,0,"Myogenesis-regulating glycosidase","TM0308",138,{"v":3E-32,"d":"3.00E-32"},"COG1501","pfam01055","Glyco_hydro_31","Glycosyl hydrolases family 31. Glycosyl hydrolases are key enzymes of carbohydrate metabolizm. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases.","GO:0005975|carbohydrate metabolic process;GO:0043568|positive regulation of insulin-like growth factor receptor signaling pathway;GO:0048741|skeletal muscle fiber development;GO:0051897|positive regulation of protein kinase B signaling;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0031965|nuclear membrane;","GO:0004553|hydrolase activity, hydrolyzing O-glycosyl compounds;","K24727","MYORG; myogenesis-regulating glycosidase [EC:3.2.1.-]"]
["ENSRNOG00000062503",124,10.43277331,43,2.766208842,3.771506024,1.91514073,{"v":7.81e-16,"d":"7.81E-16"},{"v":1.8e-15,"d":"1.80E-15"},"up","yes","ENSRNOG00000062503","lncRNA","chr15:95024031-95027881:+","gi|344238342|gb|EGV94445.1|",142,{"v":3e-07,"d":"3.00E-07"},"hypothetical protein I79_000405 [Cricetulus griseus]","gi|672028896|ref|XM_002725130.4|",3851,0,"PREDICTED: Rattus norvegicus similar to Glypican-6 precursor (LOC691984), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam06930","DUF1282","Protein of unknown function (DUF1282). This family consists of several hypothetical proteins of around 200 residues in length. The function of this family is unknown although a number of family members are thought to be putative membrane proteins.",".",".",".",".","."]
["ENSRNOG00000005342",170,14.30299567,77,4.95344374,2.887485237,1.52981357,{"v":7.86e-16,"d":"7.86E-16"},{"v":1.81e-15,"d":"1.81E-15"},"up","yes","Rassf5","protein_coding","chr13:42637549-42703024:-","gi|25742807|ref|NP_062238.1|",1904,0,"ras association domain-containing protein 5 [Rattus norvegicus]","gi|2459832|gb|AF002251.1|AF002251",3406,0,"Rattus norvegicus Maxp1 mRNA, complete cds","O35141",738,0,"Ras association domain-containing protein 5",".",".",".",".","pfam00788","RA","Ras association (RalGDS/AF-6) domain. RasGTP effectors (in cases of AF6, canoe and RalGDS); putative RasGTP effectors in other cases. Recent evidence (not yet in MEDLINE) shows that some RA domains do NOT bind RasGTP. Predicted structure similar to that determined, and that of the RasGTP-binding domain of Raf kinase.","GO:0006915|apoptotic process;GO:0007165|signal transduction;GO:0008285|negative regulation of cell proliferation;GO:0031398|positive regulation of protein ubiquitination;GO:0035556|intracellular signal transduction;GO:0042981|regulation of apoptotic process;GO:1900180|regulation of protein localization to nucleus;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005874|microtubule;","GO:0031267|small GTPase binding;GO:0042802|identical protein binding;GO:0046872|metal ion binding;","K08015","RASSF5, RAPL; Ras association domain-containing protein 5"]
["ENSRNOG00000067948",59,4.96398085,5,0.321652191,15.43275933,3.947924129,{"v":7.93e-16,"d":"7.93E-16"},1.82E-15,"up","yes","Metazoa_SRP","misc_RNA","chr6:87839673-87839972:-","gi|594691438|ref|XP_007193055.1|",518,{"v":5e-63,"d":"5.00E-63"},"PREDICTED: uncharacterized protein LOC103017900 [Balaenoptera acutorostrata scammoni]","gi|527047032|tpe|HG323686.1|",300,{"v":1e-154,"d":"1.00E-154"},"TPA: Mus musculus SRP RNA for signal recognition particle RNA",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSRNOG00000024728",297,24.98817479,186,11.9654615,2.08835863,1.062369484,1.07E-15,2.45E-15,"up","yes","Arhgap22","protein_coding","chr16:8476306-8631548:+","gi|564388205|ref|XP_006252806.1|",3458,0,"PREDICTED: rho GTPase-activating protein 22 isoform X1 [Rattus norvegicus]","gi|672079641|ref|XM_006252744.2|",2758,0,"PREDICTED: Rattus norvegicus Rho GTPase activating protein 22 (Arhgap22), transcript variant X1, mRNA","Q8BL80",1204,0,"Rho GTPase-activating protein 22",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0007165|signal transduction;GO:0090630|activation of GTPase activity;GO:0099175|regulation of postsynapse organization;","GO:0098978|glutamatergic synapse;","GO:0005096|GTPase activator activity;","K20642","ARHGAP22_24_25; Rho GTPase-activating protein 22/24/25"]
["ENSRNOG00000063964",243,20.44487028,138,8.87760047,2.30297256,1.203497222,1.07E-15,{"v":2.46e-15,"d":"2.46E-15"},"up","yes","Jdp2","protein_coding","chr6:105261373-105301485:+","gi|672056419|ref|XP_008762956.1|",1132,{"v":2e-148,"d":"2.00E-148"},"PREDICTED: jun dimerization protein 2 isoform X2 [Rattus norvegicus]","gi|672056418|ref|XM_008764734.1|",1451,0,"PREDICTED: Rattus norvegicus Jun dimerization protein 2 (Jdp2), transcript variant X1, mRNA","Q78E65",244,{"v":6e-76,"d":"6.00E-76"},"Jun dimerization protein 2",".",".",".",".","pfam00170","bZIP_1","bZIP transcription factor. The Pfam entry includes the basic region and the leucine zipper region.",".",".",".",".","."]
["ENSRNOG00000016995",84,7.067362566,18,1.157947887,6.103351147,2.609601596,1.13E-15,{"v":2.59e-15,"d":"2.59E-15"},"up","yes","Zap70","protein_coding","chr9:38989750-39011700:+","gi|564367964|ref|XP_006244823.1|",3224,0,"PREDICTED: tyrosine-protein kinase ZAP-70 isoform X2 [Rattus norvegicus]","gi|672064817|ref|XM_006244761.2|",2113,0,"PREDICTED: Rattus norvegicus zeta-chain (TCR) associated protein kinase 70 (Zap70), transcript variant X1, mRNA","P43404",1216,0,"Tyrosine-protein kinase ZAP-70",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0002250|adaptive immune response;GO:0006468|protein phosphorylation;GO:0006955|immune response;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0008150|biological_process;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0030154|cell differentiation;GO:0035556|intracellular signal transduction;GO:0043366|beta selection;GO:0045059|positive thymic T cell selection;GO:0045060|negative thymic T cell selection;GO:0045061|thymic T cell selection;GO:0045087|innate immune response;GO:0045582|positive regulation of T cell differentiation;GO:0046638|positive regulation of alpha-beta T cell differentiation;GO:0046641|positive regulation of alpha-beta T cell proliferation;GO:0046777|protein autophosphorylation;GO:0050850|positive regulation of calcium-mediated signaling;GO:0050852|T cell receptor signaling pathway;","GO:0001772|immunological synapse;GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0016020|membrane;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0042101|T cell receptor complex;GO:0045121|membrane raft;","GO:0001784|phosphotyrosine residue binding;GO:0003674|molecular_function;GO:0004672|protein kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0005102|signaling receptor binding;GO:0005524|ATP binding;","K07360","ZAP70; tyrosine-protein kinase ZAP-70 [EC:2.7.10.2]"]
["ENSRNOG00000070531",69,5.805333537,10,0.643304382,9.024240625,3.173805537,{"v":1.16e-15,"d":"1.16E-15"},{"v":2.65e-15,"d":"2.65E-15"},"up","yes","Ltb","protein_coding","chr20:3627537-3629381:-","gi|47059114|ref|NP_997672.1|",1302,{"v":6e-177,"d":"6.00E-177"},"lymphotoxin-beta [Rattus norvegicus]","gi|672085855|ref|XM_008772776.1|",1167,0,"PREDICTED: Rattus norvegicus lymphotoxin-beta (LOC103694381), mRNA","P41155",449,{"v":5e-156,"d":"5.00E-156"},"Lymphotoxin-beta",".",".",".",".","pfam00229","TNF","TNF(tumor Necrosis Factor) family.",".",".",".",".","."]
["ENSRNOG00000004772",165,13.88231933,74,4.760452426,2.916176465,1.544078023,{"v":1.34e-15,"d":"1.34E-15"},{"v":3.05e-15,"d":"3.05E-15"},"up","yes","Cytip","protein_coding","chr3:42698768-42725993:-","gi|58865742|ref|NP_001012086.1|",1581,0,"cytohesin-interacting protein [Rattus norvegicus]","gi|58865741|ref|NM_001012086.1|",1664,0,"Rattus norvegicus cytohesin 1 interacting protein (Cytip), mRNA","Q5I0L6",613,0,"Cytohesin-interacting protein",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.","GO:0030155|regulation of cell adhesion;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005769|early endosome;GO:0005829|cytosol;GO:0005938|cell cortex;",".",".","."]
["ENSRNOG00000013689",305,25.66125694,194,12.48010501,2.056173159,1.039961765,{"v":1.4e-15,"d":"1.40E-15"},3.18E-15,"up","yes","Vps18","protein_coding","chr3:106279425-106291964:+","gi|157817523|ref|NP_001099969.1|",5032,0,"vacuolar protein sorting-associated protein 18 homolog [Rattus norvegicus]","gi|197927321|ref|NM_001106499.2|",3774,0,"Rattus norvegicus VPS18 CORVET/HOPS core subunit (Vps18), mRNA","Q8R307",1910,0,"Vacuolar protein sorting-associated protein 18 homolog",".",".",".",".","pfam05131","Pep3_Vps18","Pep3/Vps18/deep orange family. This region is found in a number of protein identified as involved in golgi function and vacuolar sorting. The molecular function of this region is unknown. The members of this family contain a C-terminal ring finger domain.","GO:0006886|intracellular protein transport;GO:0006904|vesicle docking involved in exocytosis;GO:0007032|endosome organization;GO:0007033|vacuole organization;GO:0007040|lysosome organization;GO:0008333|endosome to lysosome transport;GO:0016567|protein ubiquitination;GO:0033147|negative regulation of intracellular estrogen receptor signaling pathway;GO:0046718|viral entry into host cell;GO:0048284|organelle fusion;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0005764|lysosome;GO:0005768|endosome;GO:0005769|early endosome;GO:0005770|late endosome;GO:0005884|actin filament;GO:0030123|AP-3 adaptor complex;GO:0030897|HOPS complex;GO:0033263|CORVET complex;GO:0098793|presynapse;GO:0098978|glutamatergic synapse;","GO:0003779|actin binding;GO:0005515|protein binding;GO:0019905|syntaxin binding;GO:0030674|protein binding, bridging;GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;","K20181","VPS18, PEP3; vacuolar protein sorting-associated protein 18"]
["ENSRNOG00000031058",171,14.38713094,79,5.082104617,2.830939546,1.501280941,{"v":1.61e-15,"d":"1.61E-15"},3.64E-15,"up","yes","ENSRNOG00000031058","protein_coding","chrX:14405124-14413849:+","gi|165971260|gb|AAI58678.1|",1455,0,"Was protein [Rattus norvegicus]","gi|165971259|gb|BC158677.1|",1384,0,"Rattus norvegicus Wiskott-Aldrich syndrome homolog (human), mRNA (cDNA clone MGC:187683 IMAGE:8372629), complete cds","P70315",520,{"v":5E-176,"d":"5.00E-176"},"Wiskott-Aldrich syndrome protein homolog",".",".",".",".","pfam00568","WH1","WH1 domain. WASp Homology domain 1 (WH1) domain. WASP is the protein that is defective in Wiskott-Aldrich syndrome (WAS). The majority of point mutations occur within the amino- terminal WH1 domain. The metabotropic glutamate receptors mGluR1alpha and mGluR5 bind a protein called homer, which is a WH1 domain homologue. A subset of WH1 domains has been termed a \"EVH1\" domain and appear to bind a polyproline motif.","GO:0002625|regulation of T cell antigen processing and presentation;GO:0006955|immune response;GO:0008064|regulation of actin polymerization or depolymerization;GO:0008150|biological_process;GO:0008154|actin polymerization or depolymerization;GO:0010591|regulation of lamellipodium assembly;GO:0016197|endosomal transport;GO:0030041|actin filament polymerization;GO:0030048|actin filament-based movement;GO:0032488|Cdc42 protein signal transduction;GO:0042110|T cell activation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051492|regulation of stress fiber assembly;GO:0051497|negative regulation of stress fiber assembly;GO:0071346|cellular response to interferon-gamma;GO:1905168|positive regulation of double-strand break repair via homologous recombination;GO:2000146|negative regulation of cell motility;GO:2000601|positive regulation of Arp2/3 complex-mediated actin nucleation;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005829|cytosol;GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0012506|vesicle membrane;GO:0035861|site of double-strand break;GO:0045335|phagocytic vesicle;","GO:0003674|molecular_function;GO:0003779|actin binding;GO:0017124|SH3 domain binding;GO:0019901|protein kinase binding;GO:0031267|small GTPase binding;GO:0042802|identical protein binding;GO:0043274|phospholipase binding;","K05747","WAS; Wiskott-Aldrich syndrome protein"]
["ENSRNOG00000017749",78,6.562550954,15,0.964956573,6.800876992,2.765720798,{"v":1.67e-15,"d":"1.67E-15"},{"v":3.78e-15,"d":"3.78E-15"},"up","yes","Nkg7","protein_coding","chr1:93844902-93845983:+","gi|19424202|ref|NP_598224.1|",739,{"v":5e-95,"d":"5.00E-95"},"protein NKG7 [Rattus norvegicus]","gi|298910231|emb|FQ222255.1|",590,0,"Rattus norvegicus TL0ADA26YC12 mRNA sequence","Q99PA5",230,{"v":2E-73,"d":"2.00E-73"},"Protein NKG7",".",".",".",".","pfam13903","Claudin_2","PMP-22/EMP/MP20/Claudin tight junction. Members of this family are claudins, that form tight junctions between cells.","GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;",".","."]
["ENSRNOG00000039191",121,10.18036751,42,2.701878404,3.767885147,1.913754989,{"v":1.79e-15,"d":"1.79E-15"},{"v":4.04e-15,"d":"4.04E-15"},"up","yes","Yjefn3","protein_coding","chr16:19533788-19539728:+","gi|392333569|ref|XP_001071564.3|",1254,{"v":8e-173,"d":"8.00E-173"},"PREDICTED: yjeF N-terminal domain-containing protein 3 isoform X1 [Rattus norvegicus]","gi|672029267|ref|XM_001071564.5|",756,0,"PREDICTED: Rattus norvegicus YjeF N-terminal domain containing 3 (Yjefn3), transcript variant X1, mRNA",".",".",".",".","YNL200c",134,{"v":2e-36,"d":"2.00E-36"},"COG0062","pfam03853","YjeF_N","YjeF-related protein N-terminus. YjeF-N domain is a novel version of the Rossmann fold with a set of catalytic residues and structural features that are different from the conventional dehydrogenases. YjeF-N domain is fused to Ribokinases in bacteria (YjeF), where they may be phosphatases, and to divergent Sm and the FDF domain in eukaryotes (Dcp3p and FLJ21128), where they may be involved in decapping and catalyze hydrolytic RNA-processing reactions.",".","GO:0005739|mitochondrion;","GO:0052856|NADHX epimerase activity;",".","."]
["ENSRNOG00000054404",53,4.459169238,0,0.032165219,138.6332618,7.115129629,{"v":1.9e-15,"d":"1.90E-15"},{"v":4.28e-15,"d":"4.28E-15"},"up","yes","ENSRNOG00000054404","protein_coding","chr11:55280418-55303827:+","gi|564314408|ref|XP_003752561.2|",1455,0,"PREDICTED: OX-2 membrane glycoprotein-like isoform X1 [Rattus norvegicus]","gi|672026026|ref|XM_003752513.3|",1354,0,"PREDICTED: Rattus norvegicus similar to OX-2 membrane glycoprotein precursor (MRC OX-2 antigen) (CD200 antigen) (LOC685716), transcript variant X1, mRNA","O54901",79.3,{"v":3e-15,"d":"3.00E-15"},"OX-2 membrane glycoprotein",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".","GO:0016021|integral component of membrane;",".","K06556","CD200; CD200 antigen"]
["ENSRNOG00000014837",128,10.76931439,47,3.023530595,3.561834104,1.832620323,1.92E-15,{"v":4.33e-15,"d":"4.33E-15"},"up","yes","Emilin2","protein_coding","chr9:111160712-111220352:-","gi|672066409|ref|XP_008765663.1|",5182,0,"PREDICTED: EMILIN-2 isoform X2 [Rattus norvegicus]","gi|672024432|ref|XM_006226977.2|",3079,0,"PREDICTED: Rattus norvegicus elastin microfibril interfacer 2 (Emilin2), transcript variant X1, mRNA","Q8K482",1878,0,"EMILIN-2",".",".",".",".","pfam07546","EMI","EMI domain. The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.",".","GO:0005576|extracellular region;",".","K24246","EMILIN; emilin"]
["ENSRNOG00000008570",68,5.721198268,10,0.643304382,8.893454529,3.152743921,2.26E-15,{"v":5.07e-15,"d":"5.07E-15"},"up","yes","Cadps","protein_coding","chr15:12290262-12742779:+","gi|982235320|ref|XP_015301635.1|",6481,0,"PREDICTED: calcium-dependent secretion activator 1 isoform X17 [Macaca fascicularis]","gi|110825967|ref|NM_012061.3|",3814,0,"Mus musculus Ca2+-dependent secretion activator (Cadps), transcript variant 1, mRNA","Q9ULU8",2422,0,"Calcium-dependent secretion activator 1",".",".",".",".","pfam06292","DUF1041","Domain of Unknown Function (DUF1041). This family consists of several eukaryotic domains of unknown function. Members of this family are often found in tandem repeats and co-occur with pfam00168, pfam00130 and pfam00169 domains.","GO:0006887|exocytosis;GO:0015031|protein transport;GO:0016050|vesicle organization;GO:0016082|synaptic vesicle priming;GO:0045055|regulated exocytosis;GO:0045921|positive regulation of exocytosis;GO:0045956|positive regulation of calcium ion-dependent exocytosis;GO:0050432|catecholamine secretion;GO:0099525|presynaptic dense core vesicle exocytosis;","GO:0031045|dense core granule;GO:0031410|cytoplasmic vesicle;GO:0098674|extrinsic component of neuronal dense core vesicle membrane;GO:0098793|presynapse;GO:0098978|glutamatergic synapse;","GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0019901|protein kinase binding;GO:0046872|metal ion binding;","K19933","CADPS; calcium-dependent secretion activator"]
["ENSRNOG00000002659",122,10.26450277,43,2.766208842,3.710675282,1.891681758,2.26E-15,{"v":5.07e-15,"d":"5.07E-15"},"up","yes","Ciita","protein_coding","chr10:5140178-5187440:-","gi|399154121|ref|NP_001257732.1|",5282,0,"MHC class II transactivator isoform 2 [Rattus norvegicus]","gi|399154120|ref|NM_001270803.1|",4849,0,"Rattus norvegicus class II, major histocompatibility complex, transactivator (Ciita), transcript variant 2, mRNA","P79621",1878,0,"MHC class II transactivator",".",".",".",".","pfam05729","NACHT","NACHT domain. This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006954|inflammatory response;GO:0007568|aging;GO:0034341|response to interferon-gamma;GO:0045345|positive regulation of MHC class I biosynthetic process;GO:0045348|positive regulation of MHC class II biosynthetic process;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046597|negative regulation of viral entry into host cell;GO:0046677|response to antibiotic;GO:0071257|cellular response to electrical stimulus;GO:0071346|cellular response to interferon-gamma;GO:0071360|cellular response to exogenous dsRNA;","GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0009986|cell surface;GO:0016605|PML body;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0003674|molecular_function;GO:0005524|ATP binding;GO:0008022|protein C-terminus binding;GO:0044877|protein-containing complex binding;","K08060","CIITA; MHC class II transactivator [EC:2.7.11.1]"]
["ENSRNOG00000015113",122,10.26450277,43,2.766208842,3.710675282,1.891681758,2.26E-15,{"v":5.07e-15,"d":"5.07E-15"},"up","yes","Mocos","protein_coding","chr18:15931654-15977187:+","gi|564392795|ref|XP_006254528.1|",4653,0,"PREDICTED: molybdenum cofactor sulfurase isoform X1 [Rattus norvegicus]","gi|672082732|ref|XM_006254466.2|",3105,0,"PREDICTED: Rattus norvegicus molybdenum cofactor sulfurase (Mocos), transcript variant X1, mRNA","Q14CH1",1653,0,"Molybdenum cofactor sulfurase","MA1950",254,{"v":6e-73,"d":"6.00E-73"},"COG0520","pfam00266","Aminotran_5","Aminotransferase class-V. This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.","GO:0006777|Mo-molybdopterin cofactor biosynthetic process;GO:0043545|molybdopterin cofactor metabolic process;",".","GO:0008265|Mo-molybdopterin cofactor sulfurase activity;GO:0016829|lyase activity;GO:0030151|molybdenum ion binding;GO:0030170|pyridoxal phosphate binding;GO:0102867|molybdenum cofactor sulfurtransferase activity;","K15631","ABA3; molybdenum cofactor sulfurtransferase [EC:2.8.1.9]"]
["ENSRNOG00000037148",179,15.06021309,86,5.532417684,2.722175719,1.444760197,{"v":2.32e-15,"d":"2.32E-15"},{"v":5.2e-15,"d":"5.20E-15"},"up","yes","Adap2","protein_coding","chr10:65138020-65165604:+","gi|880920145|ref|XP_005077039.2|",1804,0,"PREDICTED: arf-GAP with dual PH domain-containing protein 2 isoform X1 [Mesocricetus auratus]","gi|9910339|ref|NM_020101.1|",1640,0,"Rattus norvegicus ArfGAP with dual PH domains 2 (Adap2), mRNA","Q9JK15",696,0,"Arf-GAP with dual PH domain-containing protein 2","SPBC21D10.05c",71.2,{"v":5e-12,"d":"5.00E-12"},"COG5347","pfam01412","ArfGap","Putative GTPase activating protein for Arf. Putative zinc fingers with GTPase activating proteins (GAPs) towards the small GTPase, Arf. The GAP of ARD1 stimulates GTPase hydrolysis for ARD1 but not ARFs.","GO:0007507|heart development;GO:0043547|positive regulation of GTPase activity;GO:0048017|inositol lipid-mediated signaling;","GO:0005737|cytoplasm;GO:0005740|mitochondrial envelope;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0005096|GTPase activator activity;GO:0005545|1-phosphatidylinositol binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;GO:0043325|phosphatidylinositol-3,4-bisphosphate binding;GO:0043533|inositol 1,3,4,5 tetrakisphosphate binding;GO:0046872|metal ion binding;GO:1902936|phosphatidylinositol bisphosphate binding;","K23781","ADAP, CENTA; Arf-GAP with dual PH domain-containing protein"]
["ENSRNOG00000019043",53,4.459169238,3,0.192991315,23.10554363,4.530167129,2.38E-15,{"v":5.33e-15,"d":"5.33E-15"},"up","yes","Pdcd1","protein_coding","chr9:94418791-94431937:-","gi|157817590|ref|NP_001100397.1|",1469,0,"programmed cell death protein 1 precursor [Rattus norvegicus]","gi|672066226|ref|XM_008767395.1|",1927,0,"PREDICTED: Rattus norvegicus programmed cell death 1 (Pdcd1), transcript variant X1, mRNA","Q02242",485,{"v":1E-166,"d":"1.00E-166"},"Programmed cell death protein 1",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000065998",287,24.1468221,179,11.51514844,2.096961428,1.068300324,{"v":2.4e-15,"d":"2.40E-15"},{"v":5.39e-15,"d":"5.39E-15"},"up","yes","ENSRNOG00000065998","lncRNA","chrX:32891490-32892962:+",".",".",".",".","gi|672087360|ref|XM_008773173.1|",1473,0,"PREDICTED: Rattus norvegicus Nance-Horan syndrome (congenital cataracts and dental anomalies) (Nhs), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam13809","Tubulin_2","Tubulin like. Many of the residues conserved in Tubulin, pfam00091, are also highly conserved in this family.",".",".",".",".","."]
["ENSRNOG00000003597",153,12.8726961,66,4.24580892,3.031859498,1.600202898,2.84E-15,{"v":6.35e-15,"d":"6.35E-15"},"up","yes","Tuba4a","protein_coding","chr9:76709614-76713918:-","gi|821032162|ref|XP_012355059.1|",2315,0,"PREDICTED: tubulin alpha-4A chain isoform X2 [Nomascus leucogenys]","gi|298905785|emb|FQ212913.1|",2021,0,"Rattus norvegicus TL0AAA50YL06 mRNA sequence","Q5XIF6",895,0,"Tubulin alpha-4A chain","SPBC800.05c",717,0,"COG5023","pfam03953","Tubulin_C","Tubulin C-terminal domain. This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).","GO:0000226|microtubule cytoskeleton organization;GO:0000278|mitotic cell cycle;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005874|microtubule;GO:0015630|microtubule cytoskeleton;","GO:0003674|molecular_function;GO:0003924|GTPase activity;GO:0005200|structural constituent of cytoskeleton;GO:0005525|GTP binding;GO:0019899|enzyme binding;GO:0019901|protein kinase binding;","K07374","TUBA; tubulin alpha"]
["ENSRNOG00000070909",77,6.478415686,15,0.964956573,6.713686262,2.74710512,{"v":3.15e-15,"d":"3.15E-15"},{"v":7.01e-15,"d":"7.01E-15"},"up","yes","ENSRNOG00000070909","protein_coding","chr4:70403737-70410534:+","gi|149065398|gb|EDM15474.1|",930,{"v":8e-112,"d":"8.00E-112"},"rCG64533, partial [Rattus norvegicus]","gi|207190|gb|M63793.1|RATTCBC1",5175,0,"Rattus norvegicus T-cell receptor beta-chain (Tcrb) gene, exons 1 through 4 and partial cds","P01852",327,{"v":1E-100,"d":"1.00E-100"},"T-cell receptor beta-1 chain C region",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.",".",".",".",".","."]
["ENSRNOG00000012458",143,12.03134342,59,3.795495853,3.169900293,1.664437462,{"v":4.04e-15,"d":"4.04E-15"},{"v":8.93e-15,"d":"8.93E-15"},"up","yes","Cyp2e1","protein_coding","chr1:195840058-195864023:+","gi|564331669|ref|XP_006230582.1|",2287,0,"PREDICTED: cytochrome P450 2E1 isoform X1 [Rattus norvegicus]","gi|564331668|ref|XM_006230520.1|",1331,0,"PREDICTED: Rattus norvegicus cytochrome P450, family 2, subfamily e, polypeptide 1 (Cyp2e1), transcript variant X1, mRNA","P05182",861,0,"Cytochrome P450 2E1","all3746",85.5,{"v":9e-17,"d":"9.00E-17"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0002933|lipid hydroxylation;GO:0006082|organic acid metabolic process;GO:0006631|fatty acid metabolic process;GO:0006641|triglyceride metabolic process;GO:0006805|xenobiotic metabolic process;GO:0008202|steroid metabolic process;GO:0009410|response to xenobiotic stimulus;GO:0009617|response to bacterium;GO:0010193|response to ozone;GO:0010243|response to organonitrogen compound;GO:0016098|monoterpenoid metabolic process;GO:0018960|4-nitrophenol metabolic process;GO:0019373|epoxygenase P450 pathway;GO:0042178|xenobiotic catabolic process;GO:0045471|response to ethanol;GO:0046483|heterocycle metabolic process;","GO:0000139|Golgi membrane;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005743|mitochondrial inner membrane;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016020|membrane;GO:0031227|intrinsic component of endoplasmic reticulum membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0004497|monooxygenase activity;GO:0005506|iron ion binding;GO:0008392|arachidonic acid epoxygenase activity;GO:0008395|steroid hydroxylase activity;GO:0016491|oxidoreductase activity;GO:0016712|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0018601|4-nitrophenol 2-monooxygenase activity;GO:0019899|enzyme binding;GO:0020037|heme binding;GO:0030544|Hsp70 protein binding;GO:0051879|Hsp90 protein binding;GO:0070330|aromatase activity;","K07415","CYP2E1; cytochrome P450 family 2 subfamily E1 [EC:1.14.14.-]"]
["ENSRNOG00000037839",63,5.300521925,8,0.514643505,10.29940506,3.364489098,{"v":4.21e-15,"d":"4.21E-15"},{"v":9.3e-15,"d":"9.30E-15"},"up","yes","P2ry10","protein_coding","chrX:72111264-72212265:+","gi|672087946|ref|XP_008771567.1|",1766,0,"PREDICTED: putative P2Y purinoceptor 10 isoform X2 [Rattus norvegicus]","gi|295148047|ref|NM_001177682.1|",2696,0,"Rattus norvegicus purinergic receptor P2Y10 (P2ry10), mRNA","Q8BFU7",607,0,"Putative P2Y purinoceptor 10",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0035025|positive regulation of Rho protein signal transduction;GO:0035589|G protein-coupled purinergic nucleotide receptor signaling pathway;GO:0051482|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway;","GO:0005887|integral component of plasma membrane;","GO:0004930|G protein-coupled receptor activity;GO:0045028|G protein-coupled purinergic nucleotide receptor activity;","K04274","P2RY10; P2Y purinoceptor 10"]
["ENSRNOG00000024115",196,16.49051265,101,6.497374257,2.53802721,1.343707536,{"v":4.26e-15,"d":"4.26E-15"},{"v":9.4e-15,"d":"9.40E-15"},"up","yes","C6","protein_coding","chr2:53851985-53921275:+","gi|28570180|ref|NP_788263.1|",4944,0,"complement component C6 precursor [Rattus norvegicus]","gi|402743755|ref|NM_176074.3|",2985,0,"Rattus norvegicus complement component 6 (C6), mRNA","Q811M5",1909,0,"Complement component C6",".",".",".",".","pfam01823","MACPF","MAC/Perforin domain. The membrane-attack complex (MAC) of the complement system forms transmembrane channels. These channels disrupt the phospholipid bilayer of target cells, leading to cell lysis and death. A number of proteins participate in the assembly of the MAC. Freshly activated C5b binds to C6 to form a C5b-6 complex, then to C7 forming the C5b-7 complex. The C5b-7 complex binds to C8, which is composed of three chains (alpha, beta, and gamma), thus forming the C5b-8 complex. C5b-8 subsequently binds to C9 and acts as a catalyst in the polymerization of C9. Active MAC has a subunit composition of C5b-C6-C7-C8-C9{n}. Perforin is a protein found in cytolytic T-cell and killer cells. In the presence of calcium, perforin polymerizes into transmembrane tubules and is capable of lysing, non-specifically, a variety of target cells. There are a number of regions of similarity in the sequences of complement components C6, C7, C8-alpha, C8-beta, C9 and perforin. The X-ray crystal structure of a MACPF domain reveals that it shares a common fold with bacterial cholesterol dependent cytolysins (pfam01289) such as perfringolysin O. Three key pieces of evidence suggests that MACPF domains and CDCs are homologous: Functional similarity (pore formation), conservation of three glycine residues at a hinge in both families and conservation of a complex core fold.","GO:0001701|in utero embryonic development;GO:0001970|positive regulation of activation of membrane attack complex;GO:0006958|complement activation, classical pathway;GO:0019835|cytolysis;GO:0043065|positive regulation of apoptotic process;GO:0045087|innate immune response;GO:0045766|positive regulation of angiogenesis;GO:0045917|positive regulation of complement activation;","GO:0005576|extracellular region;GO:0005579|membrane attack complex;GO:0005615|extracellular space;","GO:0003674|molecular_function;","K03995","C6; complement component 6"]
["ENSRNOG00000002273",191,16.06983631,97,6.240052504,2.575272612,1.364725161,{"v":4.54e-15,"d":"4.54E-15"},{"v":1E-14,"d":"1.00E-14"},"up","yes","Naaa","protein_coding","chr14:15777306-15796410:+","gi|58219537|ref|NP_001010967.1|",1870,0,"N-acylethanolamine-hydrolyzing acid amidase precursor [Rattus norvegicus]","gi|77736613|ref|NM_001010967.2|",1809,0,"Rattus norvegicus N-acylethanolamine acid amidase (Naaa), mRNA","Q5KTC7",721,0,"N-acylethanolamine-hydrolyzing acid amidase",".",".",".",".","pfam15508","NAAA-beta","beta subunit of N-acylethanolamine-hydrolyzing acid amidase. NAAA-beta is a family of vertebral sequences that form the beta subunit of vertebral N-acylethanolamine-hydrolyzing acid amidase, a member of the choloylglycine hydrolase acid ceramidase family. The alpha subunit is represented by family CBAH, pfam02275.","GO:0006631|fatty acid metabolic process;GO:0006670|sphingosine metabolic process;GO:0016042|lipid catabolic process;GO:0070291|N-acylethanolamine metabolic process;GO:0070292|N-acylphosphatidylethanolamine metabolic process;","GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0019898|extrinsic component of membrane;","GO:0016810|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;GO:0017040|N-acylsphingosine amidohydrolase activity;GO:0017064|fatty acid amide hydrolase activity;GO:0047412|N-(long-chain-acyl)ethanolamine deacylase activity;GO:0102121|ceramidase activity;","K13720","NAAA; N-(long-chain-acyl)ethanolamine deacylase [EC:3.5.1.60]"]
["ENSRNOG00000046254",181,15.22848363,90,5.789739437,2.630253709,1.395201965,{"v":8.47e-15,"d":"8.47E-15"},1.85E-14,"up","yes","Adgre1","protein_coding","chr9:2242474-2398000:+","gi|56090594|ref|NP_001007558.1|",4972,0,"adhesion G protein-coupled receptor E2 precursor [Rattus norvegicus]","gi|56090593|ref|NM_001007557.1|",3226,0,"Rattus norvegicus adhesion G protein-coupled receptor E1 (Adgre1), mRNA","Q5Y4N8",1919,0,"Adhesion G protein-coupled receptor E2",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0002250|adaptive immune response;GO:0007166|cell surface receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0071944|cell periphery;","GO:0004930|G protein-coupled receptor activity;GO:0005509|calcium ion binding;","K04591","ADGRE1, EMR1; adhesion G protein-coupled receptor E1"]
["ENSRNOG00000030712",250,21.03381716,149,9.58523529,2.194397584,1.133824939,{"v":8.82e-15,"d":"8.82E-15"},1.92E-14,"up","yes","RT1-CE1","protein_coding","chr20:3555782-3559486:-","gi|57012398|ref|NP_001008832.1|",1642,0,"RT1 class I, locus CE1 precursor [Rattus norvegicus]","gi|110350025|gb|AC130591.5|",1181,0,"Rattus norvegicus BAC CH230-312A21 () complete sequence","P16391",528,0,"RT1 class I histocompatibility antigen, AA alpha chain",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.","GO:0001916|positive regulation of T cell mediated cytotoxicity;GO:0002476|antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002485|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent;GO:0002486|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0006955|immune response;GO:0010977|negative regulation of neuron projection development;","GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0045121|membrane raft;","GO:0005102|signaling receptor binding;GO:0005515|protein binding;GO:0042605|peptide antigen binding;","K06751","MHC1; MHC class I antigen"]
["ENSRNOG00000020980",50,4.206763432,0,0.032165219,130.786096,7.031065364,{"v":9.91e-15,"d":"9.91E-15"},2.15E-14,"up","yes","AABR07006278.1","protein_coding","chr1:208368386-208386814:+","gi|157821819|ref|NP_001099809.1|",711,{"v":6e-91,"d":"6.00E-91"},"membrane-spanning 4-domains, subfamily A, member 4C [Rattus norvegicus]","gi|298894680|emb|FQ227673.1|",515,0,"Rattus norvegicus TL0AEA12YF23 mRNA sequence","Q99N05",241,{"v":1e-77,"d":"1.00E-77"},"Membrane-spanning 4-domains subfamily A member 4D",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000052940",50,4.206763432,0,0.032165219,130.786096,7.031065364,{"v":9.91e-15,"d":"9.91E-15"},2.15E-14,"up","yes","AABR07030791.1","protein_coding","chr10:100056504-100078190:-","gi|564313998|ref|XP_006221095.1|",1115,{"v":6e-150,"d":"6.00E-150"},"PREDICTED: CMRF35-like molecule 5 isoform X1 [Rattus norvegicus]","gi|672025726|ref|XM_006221033.2|",738,0,"PREDICTED: Rattus norvegicus similar to MAIR-IIb (RGD1562156), transcript variant X1, mRNA","Q8VCH2",233,{"v":9e-73,"d":"9.00E-73"},"CMRF35-like molecule 5",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000022110",48,4.038492895,1,0.064330438,62.77732608,5.972171675,{"v":1E-14,"d":"1.00E-14"},{"v":2.17e-14,"d":"2.17E-14"},"up","yes","Gcsam","protein_coding","chr11:55196712-55206992:-","gi|293352180|ref|XP_001064866.2|",982,{"v":2e-123,"d":"2.00E-123"},"PREDICTED: germinal center-associated signaling and motility protein isoform X1 [Rattus norvegicus]","gi|672026024|ref|XM_003752512.3|",2825,0,"PREDICTED: Rattus norvegicus germinal center-associated, signaling and motility (Gcsam), transcript variant X1, mRNA","Q6RFH4",326,{"v":2e-103,"d":"2.00E-103"},"Germinal center-associated signaling and motility protein",".",".",".",".","pfam09695","YtfJ_HI0045","Bacterial protein of unknown function (YtfJ_HI0045). These are sequences from gamma proteobacteria that are related to the Escherichia coli protein, YtfJ.","GO:0050855|regulation of B cell receptor signaling pathway;GO:2000402|negative regulation of lymphocyte migration;",".","GO:0003779|actin binding;GO:0019901|protein kinase binding;GO:0045159|myosin II binding;",".","."]
["ENSRNOG00000018915",71,5.973604074,13,0.836295696,7.142932936,2.836516576,{"v":1.39e-14,"d":"1.39E-14"},{"v":2.99e-14,"d":"2.99E-14"},"up","yes","Tagap","protein_coding","chr1:47170725-47179792:-","gi|827342578|ref|NP_001296378.1|",3627,0,"T-cell activation Rho GTPase-activating protein [Rattus norvegicus]","gi|672012747|ref|XM_003753172.3|",3184,0,"PREDICTED: Rattus norvegicus T-cell activation RhoGTPase activating protein (Tagap), transcript variant X1, mRNA","B2RWW0",1198,0,"T-cell activation Rho GTPase-activating protein",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0007165|signal transduction;GO:0050790|regulation of catalytic activity;GO:0051607|defense response to virus;",".","GO:0005096|GTPase activator activity;","K20654","TAGAP, ARHGAP47; T-cell activation Rho GTPase-activating protein"]
["ENSRNOG00000018978",49,4.122628164,3,0.192991315,21.36172901,4.416956518,{"v":3.67e-14,"d":"3.67E-14"},{"v":7.76e-14,"d":"7.76E-14"},"up","yes","Scart1","protein_coding","chr1:195020750-195031807:+","gi|149061488|gb|EDM11911.1|",5011,0,"rCG47791, isoform CRA_b [Rattus norvegicus]","gi|157821230|ref|NM_001106312.1|",3228,0,"Rattus norvegicus CD163 molecule-like 1 (Cd163l1), mRNA","Q4G0T1",1067,0,"Scavenger receptor cysteine-rich domain-containing protein SCART1",".",".",".",".","pfam00530","SRCR","Scavenger receptor cysteine-rich domain. These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.","GO:0006897|endocytosis;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005903|brush border;GO:0009897|external side of plasma membrane;","GO:0005044|scavenger receptor activity;",".","."]
["ENSRNOG00000027808",85,7.151497835,22,1.41526964,5.053099164,2.337168492,{"v":3.83e-14,"d":"3.83E-14"},{"v":8.08e-14,"d":"8.08E-14"},"up","yes","Lilra5","protein_coding","chr1:69973292-70001718:-","gi|672035221|ref|XP_008757210.1|",1426,0,"PREDICTED: leukocyte immunoglobulin-like receptor subfamily A member 5 isoform X1 [Rattus norvegicus]","gi|672035220|ref|XM_008758988.1|",1169,0,"PREDICTED: Rattus norvegicus leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 (Lilra5), transcript variant X1, mRNA","A6NI73",257,{"v":1E-78,"d":"1.00E-78"},"Leukocyte immunoglobulin-like receptor subfamily A member 5",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0019221|cytokine-mediated signaling pathway;GO:0032695|negative regulation of interleukin-12 production;GO:0032696|negative regulation of interleukin-13 production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032733|positive regulation of interleukin-10 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0043410|positive regulation of MAPK cascade;GO:0050729|positive regulation of inflammatory response;GO:0050867|positive regulation of cell activation;GO:0051928|positive regulation of calcium ion transport;GO:0061098|positive regulation of protein tyrosine kinase activity;","GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0032396|inhibitory MHC class I receptor activity;","K06512","LILR, CD85; leukocyte immunoglobulin-like receptor"]
["ENSRNOG00000003893",200,16.82705373,109,7.012017762,2.399744881,1.26288104,{"v":4.19e-14,"d":"4.19E-14"},{"v":8.81e-14,"d":"8.81E-14"},"up","yes","Ccnjl","protein_coding","chr10:27995679-28053426:+","gi|158341651|ref|NP_001032862.2|",1856,0,"cyclin-J-like protein [Rattus norvegicus]","gi|672067173|ref|XM_006246133.2|",3222,0,"PREDICTED: Rattus norvegicus cyclin J-like (Ccnjl), transcript variant X1, mRNA","Q5SRT8",677,0,"Cyclin-J-like protein","YGR109c",57,{"v":1e-07,"d":"1.00E-07"},"COG5024","pfam02984","Cyclin_C","Cyclin, C-terminal domain. Cyclins regulate cyclin dependent kinases (CDKs). Human CCNO is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.","GO:0000079|regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0044772|mitotic cell cycle phase transition;","GO:0000307|cyclin-dependent protein kinase holoenzyme complex;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005813|centrosome;","GO:0016538|cyclin-dependent protein serine/threonine kinase regulator activity;",".","."]
["ENSRNOG00000007573",78,6.562550954,18,1.157947887,5.667397494,2.502686392,4.61E-14,{"v":9.69e-14,"d":"9.69E-14"},"up","yes","Hoxb9","protein_coding","chr10:81237312-81240818:+","gi|113680760|ref|NP_032296.2|",1262,{"v":6e-173,"d":"6.00E-173"},"homeobox protein Hox-B9 [Mus musculus]","gi|154756739|ref|NM_001100497.1|",937,0,"Rattus norvegicus homeo box B9 (Hoxb9), mRNA","P20615",490,{"v":2E-174,"d":"2.00E-174"},"Homeobox protein Hox-B9",".",".",".",".","pfam04617","Hox9_act","Hox9 activation region. This family constitutes the N termini of the paralogous homeobox proteins HoxA9, HoxB9, HoxC9 and HoxD9. The N terminal region is found to act as a transcription activation region. Btg1 and Btg2 - the B-cell translocation gene products - may function as cofactors for Hoxb9-mediated transcription. The Btg proteins modulate Hoxb9 transcriptional activity by recruiting a multiprotein Ccr4-like complex.","GO:0006351|transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0009952|anterior/posterior pattern specification;GO:0009954|proximal/distal pattern formation;GO:0030879|mammary gland development;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048704|embryonic skeletal system morphogenesis;GO:0048706|embryonic skeletal system development;GO:0060326|cell chemotaxis;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0090575|RNA polymerase II transcription factor complex;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:1990837|sequence-specific double-stranded DNA binding;","K09294","HOX_9; homeobox protein HoxB/C/D9"]
["ENSRNOG00000010575",179,15.06021309,92,5.918400313,2.54464252,1.347462996,{"v":5.68e-14,"d":"5.68E-14"},1.19E-13,"up","yes","Dapp1","protein_coding","chr2:226425898-226475423:-","gi|157819323|ref|NP_001102038.1|",1504,0,"dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide [Rattus norvegicus]","gi|157819322|ref|NM_001108568.1|",3045,0,"Rattus norvegicus dual adaptor of phosphotyrosine and 3-phosphoinositides (Dapp1), mRNA","Q9QXT1",565,0,"Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide",".",".",".",".","pfam00017","SH2","SH2 domain.",".","GO:0005886|plasma membrane;","GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;GO:0043325|phosphatidylinositol-3,4-bisphosphate binding;","K12229","DAPP1, BAM32; dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide"]
["ENSRNOG00000010045",63,5.300521925,10,0.643304382,8.239524048,3.042561003,{"v":6.16e-14,"d":"6.16E-14"},{"v":1.28e-13,"d":"1.28E-13"},"up","yes","Clec4a","protein_coding","chr4:156414688-156432402:+","gi|148235584|ref|NP_001005899.2|",1106,{"v":2e-148,"d":"2.00E-148"},"C-type lectin domain family 4 member A [Rattus norvegicus]","gi|281332176|ref|NM_001170333.1|",545,0,"Mus musculus C-type lectin domain family 4, member a2 (Clec4a2), transcript variant 1, mRNA","Q67EQ0",426,{"v":2e-148,"d":"2.00E-148"},"C-type lectin domain family 4 member A",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0001818|negative regulation of cytokine production;GO:0001819|positive regulation of cytokine production;GO:0001878|response to yeast;GO:0001879|detection of yeast;GO:0002223|stimulatory C-type lectin receptor signaling pathway;GO:0002250|adaptive immune response;GO:0002470|plasmacytoid dendritic cell antigen processing and presentation;GO:0032720|negative regulation of tumor necrosis factor production;GO:0036037|CD8-positive, alpha-beta T cell activation;GO:0042590|antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045087|innate immune response;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050832|defense response to fungus;GO:0061760|antifungal innate immune response;GO:1902533|positive regulation of intracellular signal transduction;GO:2000318|positive regulation of T-helper 17 type immune response;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0005509|calcium ion binding;GO:0005537|mannose binding;GO:0030246|carbohydrate binding;GO:0038187|pattern recognition receptor activity;","K10057","CLEC4A, CD367; C-type lectin domain family 4 member A"]
["ENSRNOG00000000956",121,10.18036751,47,3.023530595,3.367046301,1.75148356,{"v":6.97e-14,"d":"6.97E-14"},{"v":1.44e-13,"d":"1.44E-13"},"up","yes","Rasl11a","protein_coding","chr12:8258159-8262576:-","gi|564378145|ref|XP_006248896.1|",1387,0,"PREDICTED: ras-like protein family member 11A isoform X1 [Rattus norvegicus]","gi|672071969|ref|XM_006248834.2|",1056,0,"PREDICTED: Rattus norvegicus RAS-like family 11 member A (Rasl11a), transcript variant X1, mRNA","Q6IMA3",441,{"v":1E-153,"d":"1.00E-153"},"Ras-like protein family member 11A",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0045943|positive regulation of transcription by RNA polymerase I;","GO:0005730|nucleolus;","GO:0003924|GTPase activity;GO:0005525|GTP binding;","K07852","RASL11A; Ras-like protein family member 11A"]
["ENSRNOG00000054218",79,6.646686223,19,1.222278326,5.437948202,2.443062409,{"v":7.06e-14,"d":"7.06E-14"},{"v":1.46e-13,"d":"1.46E-13"},"up","yes","Il18rap","protein_coding","chr9:42768220-42800959:+","gi|672023954|ref|XP_008756243.1|",3282,0,"PREDICTED: interleukin-18 receptor accessory protein [Rattus norvegicus]","gi|672023953|ref|XM_008758021.1|",2265,0,"PREDICTED: Rattus norvegicus interleukin 18 receptor accessory protein (Il18rap), mRNA","Q9Z2B1",1088,0,"Interleukin-18 receptor accessory protein",".",".",".",".","pfam01582","TIR","TIR domain. The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.","GO:0008283|cell proliferation;GO:0035655|interleukin-18-mediated signaling pathway;GO:0042119|neutrophil activation;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0070301|cellular response to hydrogen peroxide;GO:0071345|cellular response to cytokine stimulus;GO:0071351|cellular response to interleukin-18;","GO:0005575|cellular_component;GO:0045092|interleukin-18 receptor complex;","GO:0003953|NAD+ nucleosidase activity;GO:0042007|interleukin-18 binding;GO:0042008|interleukin-18 receptor activity;","K05174","IL18RAP, ACPL, CD218b; interleukin 18 receptor accessory protein"]
["ENSRNOG00000000528",280,23.55787522,182,11.70813975,2.012093785,1.008697551,{"v":8.55e-14,"d":"8.55E-14"},{"v":1.76e-13,"d":"1.76E-13"},"up","yes","Fgd2","protein_coding","chr20:7424790-7441603:+","gi|564397249|ref|XP_006256267.1|",3436,0,"PREDICTED: FYVE, RhoGEF and PH domain-containing protein 2 isoform X1 [Rattus norvegicus]","gi|672085676|ref|XM_006256205.2|",2784,0,"PREDICTED: Rattus norvegicus FYVE, RhoGEF and PH domain containing 2 (Fgd2), transcript variant X1, mRNA","Q8BY35",1247,0,"FYVE, RhoGEF and PH domain-containing protein 2",".",".",".",".","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0007010|cytoskeleton organization;GO:0043507|positive regulation of JUN kinase activity;GO:0046847|filopodium assembly;","GO:0001726|ruffle;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005769|early endosome;GO:0005856|cytoskeleton;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0046872|metal ion binding;GO:1901981|phosphatidylinositol phosphate binding;","K05721","FGD2; FYVE, RhoGEF and PH domain containing 2"]
["ENSRNOG00000015821",82,6.899092029,21,1.350939202,5.106885654,2.352443757,{"v":8.6E-14,"d":"8.60E-14"},1.77E-13,"up","yes","Cd2","protein_coding","chr2:188710900-188724026:-","gi|56972388|gb|AAH88164.1|",1466,0,"Cd2 molecule [Rattus norvegicus]","gi|6978626|ref|NM_012830.1|",1121,0,"Rattus norvegicus Cd2 molecule (Cd2), mRNA","P08921",569,0,"T-cell surface antigen CD2",".",".",".",".","pfam05790","C2-set","Immunoglobulin C2-set domain.","GO:0032729|positive regulation of interferon-gamma production;GO:0032757|positive regulation of interleukin-8 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0034113|heterotypic cell-cell adhesion;GO:0042110|T cell activation;GO:0098609|cell-cell adhesion;","GO:0005576|extracellular region;GO:0005911|cell-cell junction;GO:0009897|external side of plasma membrane;GO:0009898|cytoplasmic side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0032991|protein-containing complex;GO:0045121|membrane raft;GO:0046658|anchored component of plasma membrane;","GO:0005102|signaling receptor binding;GO:0005515|protein binding;GO:0019901|protein kinase binding;GO:0030971|receptor tyrosine kinase binding;GO:0042802|identical protein binding;GO:0043621|protein self-association;","K06449","CD2; T-cell surface glycoprotein CD2"]
["ENSRNOG00000038740",109,9.170744282,39,2.508887089,3.655303709,1.869991281,{"v":1.05e-13,"d":"1.05E-13"},{"v":2.15e-13,"d":"2.15E-13"},"up","yes","Gimap7","protein_coding","chr4:77670367-77675272:+","gi|66730266|ref|NP_001019499.1|",1523,0,"GTPase, IMAP family member 7 [Rattus norvegicus]","gi|60551436|gb|BC091210.1|",1192,0,"Rattus norvegicus GTPase, IMAP family member 7, mRNA (cDNA clone MGC:108919 IMAGE:7381387), complete cds","Q8NHV1",327,{"v":6e-104,"d":"6.00E-104"},"GTPase IMAP family member 7",".",".",".",".","pfam04548","AIG1","AIG1 family. Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.","GO:0046039|GTP metabolic process;","GO:0005794|Golgi apparatus;GO:0005811|lipid droplet;GO:0005829|cytosol;GO:0043231|intracellular membrane-bounded organelle;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;",".","."]
["ENSRNOG00000030187",252,21.2020877,157,10.0998788,2.099241796,1.069868349,{"v":1.1E-13,"d":"1.10E-13"},2.24E-13,"up","yes","Mmp12","protein_coding","chr8:4581785-4599611:+","gi|291327537|ref|NP_446415.2|",2297,0,"macrophage metalloelastase preproprotein [Rattus norvegicus]","gi|291327536|ref|NM_053963.2|",1790,0,"Rattus norvegicus matrix metallopeptidase 12 (Mmp12), mRNA","Q63341",860,0,"Macrophage metalloelastase",".",".",".",".","pfam00413","Peptidase_M10","Matrixin. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001666|response to hypoxia;GO:0006508|proteolysis;GO:0006606|protein import into nucleus;GO:0009410|response to xenobiotic stimulus;GO:0010628|positive regulation of gene expression;GO:0014070|response to organic cyclic compound;GO:0030198|extracellular matrix organization;GO:0030574|collagen catabolic process;GO:0032727|positive regulation of interferon-alpha production;GO:0035313|wound healing, spreading of epidermal cells;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048286|lung alveolus development;GO:0050679|positive regulation of epithelial cell proliferation;GO:0050691|regulation of defense response to virus by host;GO:0060054|positive regulation of epithelial cell proliferation involved in wound healing;GO:0060309|elastin catabolic process;GO:0060339|negative regulation of type I interferon-mediated signaling pathway;GO:0060340|positive regulation of type I interferon-mediated signaling pathway;GO:0060435|bronchiole development;GO:0098586|cellular response to virus;GO:1901163|regulation of trophoblast cell migration;GO:1904905|negative regulation of endothelial cell-matrix adhesion via fibronectin;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0031012|extracellular matrix;","GO:0001046|core promoter sequence-specific DNA binding;GO:0004222|metalloendopeptidase activity;GO:0005509|calcium ion binding;GO:0005518|collagen binding;GO:0008270|zinc ion binding;GO:0043565|sequence-specific DNA binding;","K01413","MMP12; matrix metalloproteinase-12 (macrophage elastase) [EC:3.4.24.65]"]
["ENSRNOG00000037814",88,7.403903641,25,1.608260955,4.603670579,2.202784604,{"v":1.11e-13,"d":"1.11E-13"},2.26E-13,"up","yes","Cxcl17","protein_coding","chr1:80984964-80996726:-","gi|157819233|ref|NP_001100961.1|",626,{"v":3E-79,"d":"3.00E-79"},"VEGF coregulated chemokine 1 precursor [Rattus norvegicus]","gi|157819232|ref|NM_001107491.1|",795,0,"Rattus norvegicus chemokine (C-X-C motif) ligand 17 (Cxcl17), mRNA","Q5UW37",171,{"v":7e-52,"d":"7.00E-52"},"C-X-C motif chemokine 17",".",".",".",".","pfam15211","CXCL17","VEGF co-regulated chemokine 1.","GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0010759|positive regulation of macrophage chemotaxis;GO:0048246|macrophage chemotaxis;GO:0050728|negative regulation of inflammatory response;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0090026|positive regulation of monocyte chemotaxis;","GO:0005615|extracellular space;",".","K22627","CXCL17; C-X-C motif chemokine 17"]
["ENSRNOG00000027739",91,7.656309447,27,1.736921831,4.407975828,2.140116313,1.19E-13,{"v":2.42e-13,"d":"2.42E-13"},"up","yes","Cndp1","protein_coding","chr18:77984907-78007765:-","gi|56090459|ref|NP_001007688.1|",2639,0,"beta-Ala-His dipeptidase [Rattus norvegicus]","gi|672083414|ref|XM_008772135.1|",2620,0,"PREDICTED: Rattus norvegicus carnosine dipeptidase 1 (metallopeptidase M20 family) (Cndp1), transcript variant X2, mRNA","Q66HG3",1021,0,"Beta-Ala-His dipeptidase","SPBC1198.08",429,{"v":7e-140,"d":"7.00E-140"},"COG0624","pfam01546","Peptidase_M20","Peptidase family M20/M25/M40. This family includes a range of zinc metallopeptidases belonging to several families in the peptidase classification. Family M20 are Glutamate carboxypeptidases. Peptidase family M25 contains X-His dipeptidases.","GO:0006508|proteolysis;GO:0032268|regulation of cellular protein metabolic process;","GO:0005829|cytosol;","GO:0004180|carboxypeptidase activity;GO:0008233|peptidase activity;GO:0016805|dipeptidase activity;GO:0046872|metal ion binding;GO:0070573|metallodipeptidase activity;","K05604","CNDP1; beta-Ala-His dipeptidase [EC:3.4.13.20]"]
["ENSRNOG00000000433",268,22.548252,172,11.06483537,2.037829868,1.02703361,{"v":1.27e-13,"d":"1.27E-13"},{"v":2.59e-13,"d":"2.59E-13"},"up","yes","Prrt1","protein_coding","chr20:4117957-4121600:-","gi|564396747|ref|XP_006256043.1|",903,{"v":5e-111,"d":"5.00E-111"},"PREDICTED: proline-rich transmembrane protein 1 isoform X2 [Rattus norvegicus]","gi|58477189|gb|BC089986.1|",1533,0,"Rattus norvegicus proline-rich transmembrane protein 1, mRNA (cDNA clone IMAGE:7318446), complete cds","Q6MG82",161,{"v":2e-42,"d":"2.00E-42"},"Proline-rich transmembrane protein 1",".",".",".",".","pfam04505","Dispanin","Interferon-induced transmembrane protein. This family includes the human leukocyte antigen CD225, which is an interferon inducible transmembrane protein, and is associated with interferon induced cell growth suppression.","GO:0006468|protein phosphorylation;GO:0007611|learning or memory;GO:0008104|protein localization;GO:0034394|protein localization to cell surface;GO:0050808|synapse organization;GO:0060291|long-term synaptic potentiation;GO:0060292|long-term synaptic depression;GO:2000311|regulation of AMPA receptor activity;","GO:0016020|membrane;GO:0030672|synaptic vesicle membrane;GO:0098839|postsynaptic density membrane;GO:0098978|glutamatergic synapse;GO:0099055|integral component of postsynaptic membrane;","GO:0030545|receptor regulator activity;GO:0042802|identical protein binding;","K23896","PRRT1; proline-rich transmembrane protein 1"]
["ENSRNOG00000061394",114,9.591420626,43,2.766208842,3.467352313,1.793834434,1.47E-13,{"v":2.98e-13,"d":"2.98E-13"},"up","yes","Clec4e","protein_coding","chr4:156607614-156612767:-","gi|149049512|gb|EDM01966.1|",1161,{"v":2E-159,"d":"2.00E-159"},"macrophage-inducible C-type lectin [Rattus norvegicus]","gi|54312113|ref|NM_001005897.1|",706,0,"Rattus norvegicus C-type lectin domain family 4, member E (Clec4e), mRNA","Q67EQ1",442,{"v":2e-157,"d":"2.00E-157"},"C-type lectin domain family 4 member E",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0001819|positive regulation of cytokine production;GO:0002221|pattern recognition receptor signaling pathway;GO:0002292|T cell differentiation involved in immune response;GO:0006955|immune response;GO:0038094|Fc-gamma receptor signaling pathway;GO:0042742|defense response to bacterium;GO:0045087|innate immune response;GO:0061760|antifungal innate immune response;","GO:0001891|phagocytic cup;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030670|phagocytic vesicle membrane;GO:0042995|cell projection;","GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0030246|carbohydrate binding;GO:0038023|signaling receptor activity;GO:0038187|pattern recognition receptor activity;GO:0051861|glycolipid binding;","K10059","CLEC4E, MINCLE; C-type lectin domain family 4 member E"]
["ENSRNOG00000052129",229,19.26697652,138,8.87760047,2.170291013,1.117888506,{"v":2.16e-13,"d":"2.16E-13"},{"v":4.35e-13,"d":"4.35E-13"},"up","yes","Nwd1","protein_coding","chr16:17170659-17252705:-","gi|672029280|ref|XP_008770117.1|",7256,0,"PREDICTED: NACHT and WD repeat domain-containing protein 1 isoform X1 [Rattus norvegicus]","gi|755526864|ref|XM_006531087.2|",4506,0,"PREDICTED: Mus musculus NACHT and WD repeat domain containing 1 (Nwd1), transcript variant X2, mRNA","A6H603",2781,0,"NACHT domain- and WD repeat-containing protein 1",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.",".",".",".",".","."]
["ENSRNOG00000001825",261,21.95930512,167,10.74318318,2.044022219,1.031410879,{"v":2.18e-13,"d":"2.18E-13"},4.38E-13,"up","yes","Pkp2","protein_coding","chr11:84661783-84727730:-","gi|215276950|ref|NP_001093969.1|",3005,0,"plakophilin-2 [Rattus norvegicus]","gi|215276949|ref|NM_001100499.1|",1574,0,"Rattus norvegicus plakophilin 2 (Pkp2), mRNA","Q99959",991,0,"Plakophilin-2",".",".",".",".","pfam00514","Arm","Armadillo/beta-catenin-like repeat. Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.",".",".",".",".","."]
["ENSRNOG00000012611",214,18.00494749,125,8.041304773,2.239057964,1.162891876,{"v":2.44e-13,"d":"2.44E-13"},{"v":4.89e-13,"d":"4.89E-13"},"up","yes","Lpxn","protein_coding","chr1:209929202-209963084:+","gi|57526976|ref|NP_001009649.1|",1916,0,"leupaxin [Rattus norvegicus]","gi|57526975|ref|NM_001009649.1|",1617,0,"Rattus norvegicus leupaxin (Lpxn), mRNA","Q99N69",695,0,"Leupaxin",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.","GO:0006355|regulation of transcription, DNA-templated;GO:0007162|negative regulation of cell adhesion;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0008150|biological_process;GO:0033628|regulation of cell adhesion mediated by integrin;GO:0034446|substrate adhesion-dependent cell spreading;GO:0043542|endothelial cell migration;GO:0050859|negative regulation of B cell receptor signaling pathway;","GO:0002102|podosome;GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005925|focal adhesion;GO:0016607|nuclear speck;GO:0042995|cell projection;GO:0048471|perinuclear region of cytoplasm;","GO:0003674|molecular_function;GO:0003712|transcription coregulator activity;GO:0046872|metal ion binding;","K24314","LPXN; leupaxin"]
["ENSRNOG00000008588",73,6.141874611,17,1.093617449,5.616108829,2.489570892,{"v":3.47e-13,"d":"3.47E-13"},6.87E-13,"up","yes","Batf","protein_coding","chr6:105353715-105376051:+","gi|148670929|gb|EDL02876.1|",818,{"v":3e-106,"d":"3.00E-106"},"basic leucine zipper transcription factor, ATF-like, partial [Mus musculus]","gi|672056489|ref|XM_008764758.1|",969,0,"PREDICTED: Rattus norvegicus basic leucine zipper transcription factor, ATF-like (Batf), transcript variant X1, mRNA","D4A7E1",219,{"v":1e-69,"d":"1.00E-69"},"Basic leucine zipper transcriptional factor ATF-like",".",".",".",".","pfam07716","bZIP_2","Basic region leucine zipper.","GO:0001819|positive regulation of cytokine production;GO:0002320|lymphoid progenitor cell differentiation;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006974|cellular response to DNA damage stimulus;GO:0008150|biological_process;GO:0030330|DNA damage response, signal transduction by p53 class mediator;GO:0042832|defense response to protozoan;GO:0043011|myeloid dendritic cell differentiation;GO:0045064|T-helper 2 cell differentiation;GO:0045190|isotype switching;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0060218|hematopoietic stem cell differentiation;GO:0072539|T-helper 17 cell differentiation;GO:0072540|T-helper 17 cell lineage commitment;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003700|DNA-binding transcription factor activity;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09034","BATF; ATF-like basic leucine zipper transcriptional factor"]
["ENSRNOG00000048914",171,14.38713094,89,5.725408998,2.512856451,1.329328259,{"v":3.61e-13,"d":"3.61E-13"},{"v":7.15e-13,"d":"7.15E-13"},"up","yes","Traf1","protein_coding","chr3:18222054-18241807:-","gi|403420632|ref|NP_001258169.1|",1919,0,"TNF receptor-associated factor 1 [Rattus norvegicus]","gi|672045342|ref|XM_006233999.2|",1979,0,"PREDICTED: Rattus norvegicus TNF receptor-associated factor 1 (Traf1), transcript variant X1, mRNA","P39428",711,0,"TNF receptor-associated factor 1",".",".",".",".","pfam00917","MATH","MATH domain. This motif has been called the Meprin And TRAF-Homology (MATH) domain. This domain is hugely expanded in the nematode C. elegans.","GO:0033209|tumor necrosis factor-mediated signaling pathway;GO:0043122|regulation of I-kappaB kinase/NF-kappaB signaling;GO:0046330|positive regulation of JNK cascade;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0070534|protein K63-linked ubiquitination;GO:2001236|regulation of extrinsic apoptotic signaling pathway;","GO:0005737|cytoplasm;GO:0009898|cytoplasmic side of plasma membrane;GO:0098802|plasma membrane receptor complex;","GO:0005164|tumor necrosis factor receptor binding;GO:0008270|zinc ion binding;GO:0031625|ubiquitin protein ligase binding;GO:0031996|thioesterase binding;GO:0042802|identical protein binding;","K03172","TRAF1; TNF receptor-associated factor 1"]
["ENSRNOG00000013320",127,10.68517912,54,3.473843662,3.075895221,1.621006359,{"v":3.8E-13,"d":"3.80E-13"},{"v":7.5e-13,"d":"7.50E-13"},"up","yes","ENSRNOG00000013320","protein_coding","chr5:56666058-56678923:-","gi|392340381|ref|XP_001068622.3|",1583,0,"PREDICTED: spermatid-specific manchette-related protein 1 isoform X1 [Rattus norvegicus]","gi|672019226|ref|XM_001068622.5|",1099,0,"PREDICTED: Rattus norvegicus similar to testes development-related NYD-SP22 isoform 1 (RGD1561916), transcript variant X1, mRNA","Q32KP0",472,{"v":3e-165,"d":"3.00E-165"},"Spermatid-specific manchette-related protein 1",".",".",".",".","pfam15181","SMRP1","Spermatid-specific manchette-related protein 1. This family of proteins, SMRP1, is thought to have a role in spermatogenesis and may be involved in differentiation or function of ciliated cells. This family of proteins is found in eukaryotes. Proteins in this family are typically approximately 260 amino acids in length.","GO:0034622|cellular protein-containing complex assembly;","GO:0002177|manchette;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0048471|perinuclear region of cytoplasm;","GO:0043014|alpha-tubulin binding;","K18634","SMRP1; spermatid-specific manchette-related protein 1"]
["ENSRNOG00000063508",42,3.533681283,1,0.064330438,54.93016032,5.779526598,{"v":4.36e-13,"d":"4.36E-13"},{"v":8.58e-13,"d":"8.58E-13"},"up","yes","ENSRNOG00000063508","protein_coding","chr17:45622444-45643353:-","gi|135527|sp|P06335.1|TCC4_MOUSE",665,{"v":1e-85,"d":"1.00E-85"},"RecName: Full=T-cell receptor gamma chain C region 5/10-13","gi|388240393|dbj|AP012433.1|",331,{"v":1e-171,"d":"1.00E-171"},"Rattus norvegicus DNA, BAC clone: RNB1-056G15, strain: F344/Stm, complete sequence","P06335",260,{"v":3e-87,"d":"3.00E-87"},"T-cell receptor gamma chain C region 5/10-13",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.",".",".",".",".","."]
["ENSRNOG00000037757",54,4.543304507,7,0.450313067,10.08921312,3.334741755,4.51E-13,{"v":8.87e-13,"d":"8.87E-13"},"up","yes","Calhm6","protein_coding","chr20:26095592-26097278:-","gi|68163374|ref|NP_001020147.1|",1387,0,"protein FAM26F [Rattus norvegicus]","gi|298890069|emb|FQ230614.1|",1079,0,"Rattus norvegicus TL0AEA8YL17 mRNA sequence","Q561R8",538,0,"Calcium homeostasis modulator protein 6",".",".",".",".","pfam14798","Ca_hom_mod","Calcium homeostasis modulator. This family of proteins control cytosolic calcium concentration. They are transmembrane proteins which may be pore-forming ion channels.","GO:0098655|cation transmembrane transport;","GO:0005887|integral component of plasma membrane;","GO:0005261|cation channel activity;",".","."]
["ENSRNOG00000060773",125,10.51690858,53,3.409513224,3.084577736,1.625073005,{"v":5.27e-13,"d":"5.27E-13"},{"v":1.03e-12,"d":"1.03E-12"},"up","yes","Sertad4","protein_coding","chr13:104360307-104370546:-","gi|157820889|ref|NP_001101821.1|",1736,0,"SERTA domain-containing protein 4 [Rattus norvegicus]","gi|157820888|ref|NM_001108351.1|",3197,0,"Rattus norvegicus SERTA domain containing 4 (Sertad4), mRNA","A7DTG3",600,0,"SERTA domain-containing protein 4",".",".",".",".","pfam06031","SERTA","SERTA motif. This family consists of a novel motif designated as SERTA (for SEI-1, RBT1, and TARA), corresponding to the largest conserved region among TRIP-Br proteins. The function of this motif is uncertain, but the CDK4-interacting segment of p34SEI-1 (amino acid residues 44-161) includes most of the SERTA motif.",".","GO:0005634|nucleus;",".",".","."]
["ENSRNOG00000000386",157,13.20923718,79,5.082104617,2.599166718,1.378049175,{"v":8.07e-13,"d":"8.07E-13"},1.56E-12,"up","yes","Pbld1","protein_coding","chr20:25551275-25565614:-","gi|51491893|ref|NP_612539.2|",1541,0,"phenazine biosynthesis-like domain-containing protein [Rattus norvegicus]","gi|672086121|ref|XM_006256372.2|",1985,0,"PREDICTED: Rattus norvegicus phenazine biosynthesis-like protein domain containing 1 (Pbld1), transcript variant X1, mRNA","Q68G31",598,0,"Phenazine biosynthesis-like domain-containing protein","PA2770",178,{"v":6e-50,"d":"6.00E-50"},"COG0384","pfam02567","PhzC-PhzF","Phenazine biosynthesis-like protein. PhzC/PhzF is involved in dimerization of two 2,3-dihydro-3-oxo-anthranilic acid molecules to create PCA by P. fluorescens. This family also contains an uncharacterized protein Rv2715 from Mycobacterium tuberculosis, though there is no significant sequence similarity to pfam00303 members. This family appears to be distantly related to pfam01678, including containing a weak internal duplication. However members of this family do not contain the conserved cysteines that are hypothesised to be active site residues (Bateman A pers obs).","GO:0009058|biosynthetic process;GO:0030277|maintenance of gastrointestinal epithelium;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0060392|negative regulation of SMAD protein signal transduction;","GO:0005737|cytoplasm;","GO:0016853|isomerase activity;GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000002253",89,7.48803891,28,1.801252269,4.15712948,2.055587684,{"v":8.65e-13,"d":"8.65E-13"},1.67E-12,"up","yes","Wdr5b","protein_coding","chr11:64710355-64712807:-","gi|67078490|ref|NP_001019937.1|",1612,0,"WD repeat-containing protein 5B [Rattus norvegicus]","gi|67078489|ref|NM_001024766.1|",1860,0,"Rattus norvegicus WD repeat domain 5B (Wdr5b), mRNA","Q4V8C4",625,0,"WD repeat-containing protein 5B",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.","GO:0051568|histone H3-K4 methylation;","GO:0048188|Set1C/COMPASS complex;","GO:0005515|protein binding;GO:0042393|histone binding;","K14963","WDR5, SWD3, CPS30; COMPASS component SWD3"]
["ENSRNOG00000046196",57,4.795710313,9,0.578973944,8.283119414,3.050174187,{"v":8.88e-13,"d":"8.88E-13"},{"v":1.72e-12,"d":"1.72E-12"},"up","yes","Icos","protein_coding","chr9:62383832-62405672:+","gi|12018286|ref|NP_072132.1|",1065,{"v":2e-138,"d":"2.00E-138"},"inducible T-cell costimulator precursor [Rattus norvegicus]","gi|672065263|ref|XM_006245038.2|",2036,0,"PREDICTED: Rattus norvegicus inducible T-cell co-stimulator (Icos), transcript variant X3, mRNA","Q9R1T7",414,{"v":7e-140,"d":"7.00E-140"},"Inducible T-cell costimulator",".",".",".",".","pfam02961","BAF","Barrier to autointegration factor. The BAF protein has a SAM-domain-like bundle of orthogonally packed alpha-hairpins - one classic and one pseudo helix-hairpin-helix motif. The protein is involved in the prevention of retroviral DNA integration.","GO:0002517|T cell tolerance induction;GO:0031295|T cell costimulation;GO:0098609|cell-cell adhesion;","GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;","K06713","ICOS, AILIM, CD278; inducible T-cell co-stimulator"]
["ENSRNOG00000052887",143,12.03134342,68,4.374469797,2.750354666,1.45961767,{"v":9.6e-13,"d":"9.60E-13"},1.85E-12,"up","yes","Dnajc6","protein_coding","chr5:116119676-116283448:+","gi|564351832|ref|XP_006238508.1|",4387,0,"PREDICTED: putative tyrosine-protein phosphatase auxilin isoform X1 [Rattus norvegicus]","gi|672053166|ref|XM_006238448.2|",4959,0,"PREDICTED: Rattus norvegicus DnaJ (Hsp40) homolog, subfamily C, member 6 (Dnajc6), transcript variant X3, mRNA","Q80TZ3",1673,0,"Putative tyrosine-protein phosphatase auxilin",".",".",".",".","pfam10409","PTEN_C2","C2 domain of PTEN tumor-suppressor protein. This is the C2 domain-like domain, in greek key form, of the PTEN protein, phosphatidyl-inositol triphosphate phosphatase, and it is the C-terminus. This domain may well include a CBR3 loop which means it plays a central role in membrane binding. This domain associates across an extensive interface with the N-terminal phosphatase domain DSPc (pfam00782) suggesting that the C2 domain productively positions the catalytic part of the protein onto the membrane.","GO:0008150|biological_process;GO:0016191|synaptic vesicle uncoating;GO:0016311|dephosphorylation;GO:0072318|clathrin coat disassembly;GO:2000369|regulation of clathrin-dependent endocytosis;","GO:0005575|cellular_component;GO:0014069|postsynaptic density;GO:0045202|synapse;GO:0098793|presynapse;","GO:0003674|molecular_function;GO:0016791|phosphatase activity;","K09526","DNAJC6; DnaJ homolog subfamily C member 6"]
["ENSRNOG00000066026",66,5.552927731,14,0.900626135,6.16563024,2.624248372,1.05E-12,{"v":2.02e-12,"d":"2.02E-12"},"up","yes","ENSRNOG00000066026","lncRNA","chr9:86275635-86287059:+","gi|564369387|ref|XP_006245404.1|",191,{"v":9e-14,"d":"9.00E-14"},"PREDICTED: nuclear autoantigen Sp-100 isoform X2 [Rattus norvegicus]","gi|672024228|ref|XM_008758065.1|",516,0,"PREDICTED: Rattus norvegicus nuclear antigen Sp100-like (LOC100366216), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam09523","DUF2390","Protein of unknown function (DUF2390). Members of this family are bacterial hypothetical proteins, about 160 amino acids in length, found in various proteobacteria, including members of the genera Pseudomonas and Vibrio. The C-terminal region is poorly conserved and is not included in the model.",".",".",".",".","."]
["ENSRNOG00000006079",155,13.04096664,78,5.017774178,2.598954472,1.377931361,1.13E-12,{"v":2.17e-12,"d":"2.17E-12"},"up","yes","Psd4","protein_coding","chr3:7137155-7173571:+","gi|199561637|ref|NP_001128353.1|",4600,0,"PH and SEC7 domain-containing protein 4 [Rattus norvegicus]","gi|199561636|ref|NM_001134881.1|",4791,0,"Rattus norvegicus pleckstrin and Sec7 domain containing 4 (Psd4), mRNA","Q8BLR5",1566,0,"PH and SEC7 domain-containing protein 4","YDR170c",106,{"v":5e-22,"d":"5.00E-22"},"COG5307","pfam01369","Sec7","Sec7 domain. The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.","GO:0032012|regulation of ARF protein signal transduction;GO:0050790|regulation of catalytic activity;","GO:0032587|ruffle membrane;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0005543|phospholipid binding;","K12494","PSD; PH and SEC7 domain-containing protein"]
["ENSRNOG00000038835",135,11.35826127,62,3.988487167,2.847761768,1.509828461,{"v":1.16e-12,"d":"1.16E-12"},2.23E-12,"up","yes","Cd86","protein_coding","chr11:64163828-64200818:+","gi|11464989|ref|NP_064466.1|",1609,0,"T-lymphocyte activation antigen CD86 precursor [Rattus norvegicus]","gi|672071192|ref|XM_006248399.2|",1415,0,"PREDICTED: Rattus norvegicus CD86 molecule (Cd86), transcript variant X1, mRNA","P42082",399,{"v":1e-133,"d":"1.00E-133"},"T-lymphocyte activation antigen CD86",".",".",".",".","pfam08205","C2-set_2","CD80-like C2-set immunoglobulin domain. These domains belong to the immunoglobulin superfamily.","GO:0001878|response to yeast;GO:0002224|toll-like receptor signaling pathway;GO:0002309|T cell proliferation involved in immune response;GO:0002639|positive regulation of immunoglobulin production;GO:0002668|negative regulation of T cell anergy;GO:0006955|immune response;GO:0007166|cell surface receptor signaling pathway;GO:0007202|activation of phospholipase C activity;GO:0007568|aging;GO:0009410|response to xenobiotic stimulus;GO:0023035|CD40 signaling pathway;GO:0031295|T cell costimulation;GO:0032496|response to lipopolysaccharide;GO:0034138|toll-like receptor 3 signaling pathway;GO:0034341|response to interferon-gamma;GO:0042102|positive regulation of T cell proliferation;GO:0042104|positive regulation of activated T cell proliferation;GO:0042113|B cell activation;GO:0042130|negative regulation of T cell proliferation;GO:0043011|myeloid dendritic cell differentiation;GO:0051607|defense response to virus;GO:0071222|cellular response to lipopolysaccharide;GO:0071248|cellular response to metal ion;GO:0071345|cellular response to cytokine stimulus;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1990051|activation of protein kinase C activity;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0034451|centriolar satellite;GO:0043231|intracellular membrane-bounded organelle;GO:0070062|extracellular exosome;","GO:0005102|signaling receptor binding;","K05413","CD86; CD86 antigen"]
["ENSRNOG00000047414",115,9.675555894,47,3.023530595,3.200085328,1.678110374,{"v":1.4e-12,"d":"1.40E-12"},{"v":2.67e-12,"d":"2.67E-12"},"up","yes","AABR07058479.1","protein_coding","chr7:109157933-109175591:-","gi|672022243|ref|XP_008774771.1|",1432,0,"PREDICTED: LOW QUALITY PROTEIN: apolipoprotein L2-like isoform X1 [Rattus norvegicus]","gi|672059741|ref|XM_008765649.1|",1287,0,"PREDICTED: Rattus norvegicus similar to RIKEN cDNA 2210421G13 (RGD1565356), transcript variant X2, mRNA","O95236",201,{"v":2E-55,"d":"2.00E-55"},"Apolipoprotein L3",".",".",".",".","pfam05461","ApoL","Apolipoprotein L. Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.",".",".",".",".","."]
["ENSRNOG00000067495",190,15.98570104,108,6.947687324,2.300866504,1.202177281,{"v":1.4e-12,"d":"1.40E-12"},{"v":2.67e-12,"d":"2.67E-12"},"up","yes","ENSRNOG00000067495","lncRNA","chr17:13575472-13597642:+","gi|884938981|ref|XP_012997027.1|",583,{"v":7E-139,"d":"7.00E-139"},"PREDICTED: LOW QUALITY PROTEIN: endogenous retrovirus group K member 25 Pol protein-like [Cavia porcellus]","gi|114053514|gb|AC154581.3|",911,0,"Mus musculus BAC clone RP23-381G5 from chromosome 13, complete sequence",".",".",".",".",".",".",".",".","pfam00692","dUTPase","dUTPase. dUTPase hydrolyses dUTP to dUMP and pyrophosphate.",".",".",".",".","."]
["ENSRNOG00000025998",142,11.94720815,68,4.374469797,2.731121417,1.449493453,{"v":1.5e-12,"d":"1.50E-12"},{"v":2.86e-12,"d":"2.86E-12"},"up","yes","Crybg1","protein_coding","chr20:47426183-47621392:-","gi|672086845|ref|XP_008771253.1|",9879,0,"PREDICTED: absent in melanoma 1 protein isoform X2 [Rattus norvegicus]","gi|755532767|ref|XM_006512498.2|",4506,0,"PREDICTED: Mus musculus absent in melanoma 1 (Aim1), transcript variant X1, mRNA","Q9Y4K1",2340,0,"Beta/gamma crystallin domain-containing protein 1",".",".",".",".","pfam00030","Crystall","Beta/Gamma crystallin. The alignment comprises two Greek key motifs since the similarity between them is very low.","GO:0008150|biological_process;","GO:0005575|cellular_component;","GO:0003674|molecular_function;GO:0030246|carbohydrate binding;",".","."]
["ENSRNOG00000002903",253,21.28622297,165,10.6145223,2.005386805,1.003880535,1.61E-12,{"v":3.05e-12,"d":"3.05E-12"},"up","yes","Specc1","protein_coding","chr10:46638809-46912802:+","gi|672067893|ref|XP_008766045.1|",5022,0,"PREDICTED: cytospin-B isoform X4 [Rattus norvegicus]","gi|672067892|ref|XM_008767823.1|",6469,0,"PREDICTED: Rattus norvegicus sperm antigen with calponin homology and coiled-coil domains 1 (Specc1), transcript variant X6, mRNA","Q5SXY1",1879,0,"Cytospin-B","SPAC15A10.08",96.7,{"v":3e-19,"d":"3.00E-19"},"COG5069","pfam00307","CH","Calponin homology (CH) domain. The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.","GO:0030036|actin cytoskeleton organization;","GO:0001650|fibrillar center;GO:0005654|nucleoplasm;GO:0005815|microtubule organizing center;GO:0005829|cytosol;GO:0031941|filamentous actin;GO:0043231|intracellular membrane-bounded organelle;",".","K23028","SPECC1; cytospin"]
["ENSRNOG00000013526",201,16.911189,118,7.590991706,2.227797059,1.155617817,1.66E-12,{"v":3.14e-12,"d":"3.14E-12"},"up","yes","Rassf4","protein_coding","chr4:149897543-149932411:-","gi|66730441|ref|NP_001019446.1|",1414,0,"ras association domain-containing protein 4 [Rattus norvegicus]","gi|66730440|ref|NM_001024275.1|",2412,0,"Rattus norvegicus Ras association domain family member 4 (Rassf4), mRNA","Q566C5",549,0,"Ras association domain-containing protein 4",".",".",".",".","pfam00788","RA","Ras association (RalGDS/AF-6) domain. RasGTP effectors (in cases of AF6, canoe and RalGDS); putative RasGTP effectors in other cases. Recent evidence (not yet in MEDLINE) shows that some RA domains do NOT bind RasGTP. Predicted structure similar to that determined, and that of the RasGTP-binding domain of Raf kinase.","GO:0007165|signal transduction;",".",".","K09851","RASSF2_4; Ras association domain-containing protein 2/4"]
["ENSRNOG00000000855",89,7.48803891,29,1.865582707,4.013780188,2.004961611,1.98E-12,{"v":3.72e-12,"d":"3.72E-12"},"up","yes","Lst1","protein_coding","chr20:3634749-3637997:+","gi|260166685|ref|NP_072156.2|",520,{"v":4e-65,"d":"4.00E-65"},"leukocyte-specific transcript 1 protein [Rattus norvegicus]","gi|260166684|ref|NM_022634.2|",438,0,"Rattus norvegicus leukocyte specific transcript 1 (Lst1), mRNA","O08843",79.7,{"v":3e-18,"d":"3.00E-18"},"Leukocyte-specific transcript 1 protein",".",".",".",".","pfam05083","LST1","LST-1 protein. B144/LST1 is a gene encoded in the human major histocompatibility complex that produces multiple forms of alternatively spliced mRNA and encodes peptides fewer than 100 amino acids in length. B144/LST1 is strongly expressed in dendritic cells. Transfection of B144/LST1 into a variety of cells induces morphologic changes including the production of long, thin filopodia.","GO:0000902|cell morphogenesis;GO:0006955|immune response;GO:0008150|biological_process;GO:0016358|dendrite development;GO:0050672|negative regulation of lymphocyte proliferation;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;",".","."]
["ENSRNOG00000007823",90,7.572174178,30,1.929913146,3.92358288,1.972171675,{"v":2.57e-12,"d":"2.57E-12"},{"v":4.8e-12,"d":"4.80E-12"},"up","yes","Hoxb6","protein_coding","chr10:81265056-81267449:+","gi|532051317|ref|XP_005368417.1|",855,{"v":8e-110,"d":"8.00E-110"},"PREDICTED: homeobox protein Hox-B6 [Microtus ochrogaster]","gi|672069229|ref|XM_006247232.2|",1304,0,"PREDICTED: Rattus norvegicus homeo box B6 (Hoxb6), transcript variant X2, mRNA","P09023",333,{"v":4e-111,"d":"4.00E-111"},"Homeobox protein Hox-B6",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0009952|anterior/posterior pattern specification;GO:0034101|erythrocyte homeostasis;GO:0048704|embryonic skeletal system morphogenesis;GO:0048706|embryonic skeletal system development;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837|sequence-specific double-stranded DNA binding;","K09306","HOX_6; homeobox protein HoxA/B/C6"]
["ENSRNOG00000010665",90,7.572174178,30,1.929913146,3.92358288,1.972171675,{"v":2.57e-12,"d":"2.57E-12"},{"v":4.8e-12,"d":"4.80E-12"},"up","yes","Ccr7","protein_coding","chr10:84097381-84108309:-","gi|41054914|ref|NP_955783.1|",1823,0,"C-C chemokine receptor type 7 precursor [Rattus norvegicus]","gi|58477680|gb|BC089762.1|",1936,0,"Rattus norvegicus chemokine (C-C motif) receptor 7, mRNA (cDNA clone MGC:108519 IMAGE:7381637), complete cds","P47774",674,0,"C-C chemokine receptor type 7",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0002408|myeloid dendritic cell chemotaxis;GO:0002606|positive regulation of dendritic cell antigen processing and presentation;GO:0002885|positive regulation of hypersensitivity;GO:0002922|positive regulation of humoral immune response;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0019722|calcium-mediated signaling;GO:0032496|response to lipopolysaccharide;GO:0032649|regulation of interferon-gamma production;GO:0032651|regulation of interleukin-1 beta production;GO:0032695|negative regulation of interleukin-12 production;GO:0032735|positive regulation of interleukin-12 production;GO:0038115|chemokine (C-C motif) ligand 19 signaling pathway;GO:0038116|chemokine (C-C motif) ligand 21 signaling pathway;GO:0045060|negative thymic T cell selection;GO:0048872|homeostasis of number of cells;GO:0050862|positive regulation of T cell receptor signaling pathway;GO:0060326|cell chemotaxis;GO:0071345|cellular response to cytokine stimulus;GO:0090023|positive regulation of neutrophil chemotaxis;GO:0097029|mature conventional dendritic cell differentiation;GO:2000510|positive regulation of dendritic cell chemotaxis;GO:2000522|positive regulation of immunological synapse formation;GO:2000525|positive regulation of T cell costimulation;GO:2000526|positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation;","GO:0005739|mitochondrion;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0016493|C-C chemokine receptor activity;GO:0019957|C-C chemokine binding;GO:0035757|chemokine (C-C motif) ligand 19 binding;GO:0035758|chemokine (C-C motif) ligand 21 binding;GO:0038117|C-C motif chemokine 19 receptor activity;GO:0038121|C-C motif chemokine 21 receptor activity;","K04182","CCR7, CD197; C-C chemokine receptor type 7"]
["ENSRNOG00000012964",45,3.786087089,4,0.257321753,14.7134358,3.879062271,{"v":2.65e-12,"d":"2.65E-12"},{"v":4.93e-12,"d":"4.93E-12"},"up","yes","Ccr6","protein_coding","chr1:52474168-52498603:-","gi|61557091|ref|NP_001013163.1|",1803,0,"C-C chemokine receptor type 6 [Rattus norvegicus]","gi|672034413|ref|XM_008758755.1|",2940,0,"PREDICTED: Rattus norvegicus chemokine (C-C motif) receptor 6 (Ccr6), transcript variant X1, mRNA","O54689",610,0,"C-C chemokine receptor type 6",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0002523|leukocyte migration involved in inflammatory response;GO:0006935|chemotaxis;GO:0006955|immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0010634|positive regulation of epithelial cell migration;GO:0019722|calcium-mediated signaling;GO:0048290|isotype switching to IgA isotypes;GO:0060326|cell chemotaxis;GO:0060474|positive regulation of flagellated sperm motility involved in capacitation;GO:0070098|chemokine-mediated signaling pathway;GO:0072676|lymphocyte migration;GO:0072678|T cell migration;GO:0072679|thymocyte migration;GO:1904155|DN2 thymocyte differentiation;GO:1904156|DN3 thymocyte differentiation;GO:2000404|regulation of T cell migration;GO:2000510|positive regulation of dendritic cell chemotaxis;","GO:0005575|cellular_component;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0036126|sperm flagellum;GO:0097225|sperm midpiece;GO:0097228|sperm principal piece;GO:0097524|sperm plasma membrane;","GO:0003674|molecular_function;GO:0016493|C-C chemokine receptor activity;GO:0019957|C-C chemokine binding;","K04181","CCR6, CD196; C-C chemokine receptor type 6"]
["ENSRNOG00000000441",155,13.04096664,80,5.146435055,2.53398061,1.341405485,{"v":3.19e-12,"d":"3.19E-12"},{"v":5.92e-12,"d":"5.92E-12"},"up","yes","Gpsm3","protein_coding","chr20:4157123-4159035:-","gi|51571901|ref|NP_001003974.1|",339,{"v":3E-34,"d":"3.00E-34"},"G-protein-signaling modulator 3 [Rattus norvegicus]","gi|56961638|ref|NM_001003974.2|",781,0,"Rattus norvegicus G-protein signaling modulator 3 (Gpsm3), mRNA","Q6MG88",135,{"v":9e-36,"d":"9.00E-36"},"G-protein-signaling modulator 3",".",".",".",".","pfam02188","GoLoco","GoLoco motif.","GO:0002690|positive regulation of leukocyte chemotaxis;GO:0006955|immune response;GO:0050729|positive regulation of inflammatory response;GO:0050790|regulation of catalytic activity;GO:1900017|positive regulation of cytokine production involved in inflammatory response;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;","GO:0030695|GTPase regulator activity;","K15838","GPSM3, AGS4; G-protein signaling modulator 3"]
["ENSRNOG00000046683",216,18.17321803,133,8.555948279,2.124044867,1.086814241,{"v":3.26e-12,"d":"3.26E-12"},{"v":6.04e-12,"d":"6.04E-12"},"up","yes","Lilrb3","protein_coding","chr1:69928945-69939048:-","gi|392337441|ref|XP_001070618.3|",4166,0,"PREDICTED: leukocyte immunoglobulin-like receptor subfamily B member 3 isoform X2 [Rattus norvegicus]","gi|672035326|ref|XM_006228230.2|",2925,0,"PREDICTED: Rattus norvegicus similar to PIRB1 (RGD1566307), transcript variant X9, mRNA","P97484",593,0,"Leukocyte immunoglobulin-like receptor subfamily B member 3",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.",".","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;",".","K06512","LILR, CD85; leukocyte immunoglobulin-like receptor"]
["ENSRNOG00000036649",163,13.71404879,87,5.596748122,2.45036019,1.292993833,{"v":3.74e-12,"d":"3.74E-12"},{"v":6.91e-12,"d":"6.91E-12"},"up","yes","Pwwp2b","protein_coding","chr1:194041341-194059958:+","gi|564331527|ref|XP_006230528.1|",2634,0,"PREDICTED: PWWP domain-containing protein 2B isoform X1 [Rattus norvegicus]","gi|672038909|ref|XM_006230466.2|",2530,0,"PREDICTED: Rattus norvegicus PWWP domain containing 2B (Pwwp2b), transcript variant X1, mRNA","Q6NUJ5",707,0,"PWWP domain-containing protein 2B",".",".",".",".","pfam00855","PWWP","PWWP domain. The PWWP domain is named after a conserved Pro-Trp-Trp-Pro motif. The domain binds to Histone-4 methylated at lysine-20, H4K20me, suggesting that it is methyl-lysine recognition motif. Removal of two conserved aromatic residues in a hydrophobic cavity created by this domain within the full-length protein, Pdp1, abolishes the interaction o f the protein with H4K20me3. In fission yeast, Set9 is the sole enzyme that catalyses all three states of H4K20me, and Set9-mediated H4K20me is required for efficient recruitment of checkpoint protein Crb2 to sites of DNA damage. The methylation of H4K20 is involved in a diverse array of cellular processes, such as organizing higher-order chromatin, maintaining genome stability, and regulating cell-cycle progression.",".","GO:0005654|nucleoplasm;",".",".","."]
["ENSRNOG00000016535",42,3.533681283,3,0.192991315,18.31005344,4.194564097,{"v":4.55e-12,"d":"4.55E-12"},{"v":8.35e-12,"d":"8.35E-12"},"up","yes","Ccl22","lncRNA","chr19:10257601-10264400:-","gi|149032436|gb|EDL87327.1|",875,{"v":7e-111,"d":"7.00E-111"},"chemokine (C-C motif) ligand 22 [Rattus norvegicus]","gi|57528025|ref|NM_057203.1|",1742,0,"Rattus norvegicus chemokine (C-C motif) ligand 22 (Ccl22), mRNA","O88430",152,{"v":2e-42,"d":"2.00E-42"},"C-C motif chemokine 22",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0002548|monocyte chemotaxis;GO:0006954|inflammatory response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0008150|biological_process;GO:0030593|neutrophil chemotaxis;GO:0031640|killing of cells of other organism;GO:0043547|positive regulation of GTPase activity;GO:0048247|lymphocyte chemotaxis;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098|chemokine-mediated signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;","GO:0005575|cellular_component;GO:0005615|extracellular space;","GO:0003674|molecular_function;GO:0008009|chemokine activity;GO:0048020|CCR chemokine receptor binding;","K21095","CCL22; C-C motif chemokine 22"]
["ENSRNOG00000025108",215,18.08908276,133,8.555948279,2.114211326,1.080119589,{"v":4.67e-12,"d":"4.67E-12"},{"v":8.56e-12,"d":"8.56E-12"},"up","yes","Ankrd35","protein_coding","chr2:184207071-184227063:+","gi|564300719|ref|XP_006224285.1|",3749,0,"PREDICTED: ankyrin repeat domain-containing protein 35 isoform X2 [Rattus norvegicus]","gi|672016109|ref|XM_001063190.5|",3363,0,"PREDICTED: Rattus norvegicus ankyrin repeat domain 35 (Ankrd35), transcript variant X1, mRNA",".",".",".",".","all2748",92.8,{"v":7e-19,"d":"7.00E-19"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).",".",".",".",".","."]
["ENSRNOG00000010819",111,9.33901482,46,2.959200157,3.15592536,1.658063085,{"v":5.18e-12,"d":"5.18E-12"},{"v":9.47e-12,"d":"9.47E-12"},"up","yes","Hspa4l","protein_coding","chr2:123740384-123793084:+","gi|564336295|ref|XP_006232359.1|",5360,0,"PREDICTED: heat shock 70 kDa protein 4L isoform X2 [Rattus norvegicus]","gi|672042082|ref|XM_006232297.2|",4150,0,"PREDICTED: Rattus norvegicus heat shock protein 4-like (Hspa4l), transcript variant X1, mRNA","P48722",1717,0,"Heat shock 70 kDa protein 4L","SPAC110.04c",454,{"v":8e-143,"d":"8.00E-143"},"COG0443","pfam00012","HSP70","Hsp70 protein. Hsp70 chaperones help to fold many proteins. Hsp70 assisted folding involves repeated cycles of substrate binding and release. Hsp70 activity is ATP dependent. Hsp70 proteins are made up of two regions: the amino terminus is the ATPase domain and the carboxyl terminus is the substrate binding region.","GO:0006457|protein folding;GO:0006986|response to unfolded protein;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0005524|ATP binding;","K09485","HSP110; heat shock protein 110kDa"]
["ENSRNOG00000009354",191,16.06983631,112,7.205009077,2.23037003,1.157283081,{"v":5.55e-12,"d":"5.55E-12"},{"v":1.01e-11,"d":"1.01E-11"},"up","yes","Nrarp","protein_coding","chr3:7992552-7995133:+","gi|795540420|ref|XP_011904291.1|",627,{"v":3e-72,"d":"3.00E-72"},"PREDICTED: notch-regulated ankyrin repeat-containing protein [Cercocebus atys]","gi|219555687|ref|NM_001143750.1|",2552,0,"Rattus norvegicus Notch-regulated ankyrin repeat protein (Nrarp), mRNA","Q91ZA8",228,{"v":1e-68,"d":"1.00E-68"},"Notch-regulated ankyrin repeat-containing protein",".",".",".",".","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001569|branching involved in blood vessel morphogenesis;GO:0001938|positive regulation of endothelial cell proliferation;GO:0002040|sprouting angiogenesis;GO:0002043|blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:0007219|Notch signaling pathway;GO:0022407|regulation of cell-cell adhesion;GO:0032525|somite rostral/caudal axis specification;GO:0045581|negative regulation of T cell differentiation;GO:0045746|negative regulation of Notch signaling pathway;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:1902367|negative regulation of Notch signaling pathway involved in somitogenesis;",".",".",".","."]
["ENSRNOG00000039048",84,7.067362566,27,1.736921831,4.068900765,2.024639095,6.03E-12,{"v":1.1e-11,"d":"1.10E-11"},"up","yes","Cd200r1","protein_coding","chr11:55887717-55921285:-","gi|13027398|ref|NP_076443.1|",1504,0,"cell surface glycoprotein CD200 receptor 1 precursor [Rattus norvegicus]","gi|672071194|ref|XM_008768743.1|",1760,0,"PREDICTED: Rattus norvegicus CD200 receptor 1 (Cd200r1), transcript variant X1, mRNA","Q9ES58",583,0,"Cell surface glycoprotein CD200 receptor 1",".",".",".",".","pfam08205","C2-set_2","CD80-like C2-set immunoglobulin domain. These domains belong to the immunoglobulin superfamily.","GO:0032715|negative regulation of interleukin-6 production;GO:0034113|heterotypic cell-cell adhesion;GO:0150077|regulation of neuroinflammatory response;GO:0150079|negative regulation of neuroinflammatory response;GO:1901215|negative regulation of neuron death;GO:1905522|negative regulation of macrophage migration;GO:2000405|negative regulation of T cell migration;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0043235|receptor complex;","GO:0038023|signaling receptor activity;GO:0086080|protein binding involved in heterotypic cell-cell adhesion;","K21668","CD200R; cell surface glycoprotein CD200 receptor"]
["ENSRNOG00000021856",94,7.908715253,34,2.187234898,3.61585089,1.854335185,{"v":6.68e-12,"d":"6.68E-12"},{"v":1.21e-11,"d":"1.21E-11"},"up","yes","Lat2","protein_coding","chr12:22104219-22118288:+","gi|564378917|ref|XP_006249222.1|",843,{"v":3e-107,"d":"3.00E-107"},"PREDICTED: linker for activation of T-cells family member 2 isoform X1 [Rattus norvegicus]","gi|672072670|ref|XM_006249160.2|",1235,0,"PREDICTED: Rattus norvegicus linker for activation of T cells family, member 2 (Lat2), transcript variant X3, mRNA","Q8CGL2",328,{"v":1E-108,"d":"1.00E-108"},"Linker for activation of T-cells family member 2",".",".",".",".","pfam15402","Spc7_N","N-terminus of kinetochore NMS complex subunit Spc7.","GO:0002250|adaptive immune response;GO:0002764|immune response-regulating signaling pathway;GO:0019722|calcium-mediated signaling;GO:0035556|intracellular signal transduction;GO:0042113|B cell activation;GO:0043303|mast cell degranulation;GO:0050853|B cell receptor signaling pathway;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0045121|membrane raft;","GO:0042169|SH2 domain binding;",".","."]
["ENSRNOG00000025805",39,3.281275477,2,0.128660876,25.50328872,4.672611394,8.11E-12,1.46E-11,"up","yes","Ms4a14","protein_coding","chr1:207949426-207964937:-","gi|149062445|gb|EDM12868.1|",5128,0,"rCG47812, isoform CRA_a [Rattus norvegicus]","gi|31342056|ref|NM_181082.2|",3764,0,"Rattus norvegicus membrane spanning 4-domains A14 (Ms4a14), mRNA","Q96JA4",282,{"v":4e-80,"d":"4.00E-80"},"Membrane-spanning 4-domains subfamily A member 14",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.",".","GO:0016021|integral component of membrane;",".","K22192","MS4A14; membrane-spanning 4-domains subfamily A member 14"]
["ENSRNOG00000051986",114,9.591420626,49,3.152191471,3.04277856,1.605389345,{"v":8.31e-12,"d":"8.31E-12"},{"v":1.5E-11,"d":"1.50E-11"},"up","yes","Plcg2","protein_coding","chr19:45547416-45683930:+","gi|148679636|gb|EDL11583.1|",6979,0,"phospholipase C, gamma 2 [Mus musculus]","gi|8393983|ref|NM_017168.1|",4282,0,"Rattus norvegicus phospholipase C, gamma 2 (Plcg2), mRNA","P24135",2620,0,"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2",".",".",".",".","pfam00388","PI-PLC-X","Phosphatidylinositol-specific phospholipase C, X domain. This associates with pfam00387 to form a single structural unit.","GO:0001775|cell activation;GO:0001878|response to yeast;GO:0002092|positive regulation of receptor internalization;GO:0002223|stimulatory C-type lectin receptor signaling pathway;GO:0002224|toll-like receptor signaling pathway;GO:0002281|macrophage activation involved in immune response;GO:0002316|follicular B cell differentiation;GO:0002732|positive regulation of dendritic cell cytokine production;GO:0006661|phosphatidylinositol biosynthetic process;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0009395|phospholipid catabolic process;GO:0010468|regulation of gene expression;GO:0010628|positive regulation of gene expression;GO:0010634|positive regulation of epithelial cell migration;GO:0019216|regulation of lipid metabolic process;GO:0019722|calcium-mediated signaling;GO:0030183|B cell differentiation;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0032026|response to magnesium ion;GO:0032237|activation of store-operated calcium channel activity;GO:0032481|positive regulation of type I interferon production;GO:0032496|response to lipopolysaccharide;GO:0032733|positive regulation of interleukin-10 production;GO:0032735|positive regulation of interleukin-12 production;GO:0032743|positive regulation of interleukin-2 production;GO:0032747|positive regulation of interleukin-23 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032959|inositol trisphosphate biosynthetic process;GO:0033198|response to ATP;GO:0035556|intracellular signal transduction;GO:0043069|negative regulation of programmed cell death;GO:0043122|regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043410|positive regulation of MAPK cascade;GO:0048678|response to axon injury;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050850|positive regulation of calcium-mediated signaling;GO:0050852|T cell receptor signaling pathway;GO:0050853|B cell receptor signaling pathway;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051209|release of sequestered calcium ion into cytosol;GO:0060100|positive regulation of phagocytosis, engulfment;GO:0060907|positive regulation of macrophage cytokine production;GO:0061760|antifungal innate immune response;GO:0070884|regulation of calcineurin-NFAT signaling cascade;GO:0071277|cellular response to calcium ion;GO:0071396|cellular response to lipid;GO:0150078|positive regulation of neuroinflammatory response;GO:1900227|positive regulation of NLRP3 inflammasome complex assembly;GO:1902808|positive regulation of cell cycle G1/S phase transition;GO:1903428|positive regulation of reactive oxygen species biosynthetic process;GO:1903721|positive regulation of I-kappaB phosphorylation;GO:1990858|cellular response to lectin;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0032587|ruffle membrane;GO:0048471|perinuclear region of cytoplasm;GO:0097708|intracellular vesicle;","GO:0001784|phosphotyrosine residue binding;GO:0004435|phosphatidylinositol phospholipase C activity;GO:0005515|protein binding;GO:0019901|protein kinase binding;GO:0097110|scaffold protein binding;GO:0140031|phosphorylation-dependent protein binding;GO:1990782|protein tyrosine kinase binding;","K05859","PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]"]
["ENSRNOG00000021474",92,7.740444715,33,2.12290446,3.646157828,1.866377011,{"v":9.05e-12,"d":"9.05E-12"},{"v":1.63e-11,"d":"1.63E-11"},"up","yes","Siglec5","protein_coding","chr1:93768319-93776694:+","gi|564327829|ref|XP_006229008.1|",2946,0,"PREDICTED: sialic acid-binding Ig-like lectin 5 isoform X3 [Rattus norvegicus]","gi|164663859|ref|NM_001106249.2|",2466,0,"Rattus norvegicus sialic acid binding Ig-like lectin 5 (Siglec5), mRNA","Q920G3",866,0,"Sialic acid-binding Ig-like lectin 5",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0007155|cell adhesion;GO:0030100|regulation of endocytosis;","GO:0005764|lysosome;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0033691|sialic acid binding;GO:0048029|monosaccharide binding;","K06549","SIGLEC5, CD170; sialic acid binding Ig-like lectin 5"]
["ENSRNOG00000000962",236,19.8559234,154,9.90688748,2.004254458,1.003065683,{"v":9.19e-12,"d":"9.19E-12"},{"v":1.65e-11,"d":"1.65E-11"},"up","yes","Slc15a4","protein_coding","chr12:29063015-29082480:+","gi|56585206|gb|AAH87709.1|",2187,0,"Solute carrier family 15, member 4 [Rattus norvegicus]","gi|56585205|gb|BC087709.1|",2726,0,"Rattus norvegicus solute carrier family 15, member 4, mRNA (cDNA clone MGC:105315 IMAGE:7315369), complete cds","O09014",842,0,"Solute carrier family 15 member 4","SPBC13A2.04c",99,{"v":2e-20,"d":"2.00E-20"},"COG3104","pfam00854","PTR2","POT family. The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.","GO:0015031|protein transport;GO:0015817|histidine transport;GO:0015835|peptidoglycan transport;GO:0033023|mast cell homeostasis;GO:0034157|positive regulation of toll-like receptor 7 signaling pathway;GO:0034161|positive regulation of toll-like receptor 8 signaling pathway;GO:0034165|positive regulation of toll-like receptor 9 signaling pathway;GO:0045087|innate immune response;GO:0045089|positive regulation of innate immune response;GO:0048302|regulation of isotype switching to IgG isotypes;GO:0070424|regulation of nucleotide-binding oligomerization domain containing signaling pathway;GO:0070430|positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway;GO:0070434|positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0089708|L-histidine transmembrane export from vacuole;GO:0140206|dipeptide import across plasma membrane;GO:1902600|proton transmembrane transport;","GO:0005765|lysosomal membrane;GO:0010008|endosome membrane;GO:0031303|integral component of endosome membrane;GO:0031901|early endosome membrane;GO:0036020|endolysosome membrane;GO:1905103|integral component of lysosomal membrane;","GO:0005290|L-histidine transmembrane transporter activity;GO:0015333|peptide:proton symporter activity;GO:0015647|peptidoglycan transmembrane transporter activity;GO:0071916|dipeptide transmembrane transporter activity;","K14638","SLC15A3_4, PHT; solute carrier family 15 (peptide/histidine transporter), member 3/4"]
["ENSRNOG00000065679",37,3.11300494,1,0.064330438,48.39085552,5.59666254,{"v":1.08e-11,"d":"1.08E-11"},{"v":1.92e-11,"d":"1.92E-11"},"up","yes","ENSRNOG00000065679","protein_coding","chr15:27521496-27586880:+","gi|6724235|gb|AAF26903.1|AF196266_1",858,{"v":1e-111,"d":"1.00E-111"},"T cell receptor J delta 2 [Rattus norvegicus]","gi|68534400|gb|BC099216.1|",1097,0,"Rattus norvegicus similar to T cell receptor V delta 6, mRNA (cDNA clone MGC:116392 IMAGE:7384680), complete cds","B7Z8K6",231,{"v":6e-73,"d":"6.00E-73"},"T-cell receptor delta chain C region",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.",".",".",".",".","."]
["ENSRNOG00000026592",208,17.50013588,129,8.298626526,2.108799067,1.076421637,{"v":1.18e-11,"d":"1.18E-11"},{"v":2.1e-11,"d":"2.10E-11"},"up","yes","Rhbdl2","protein_coding","chr5:136037305-136081969:+","gi|564352686|ref|XP_006238864.1|",1392,0,"PREDICTED: rhomboid-related protein 2 isoform X1 [Rattus norvegicus]","gi|672053654|ref|XM_006238802.2|",1237,0,"PREDICTED: Rattus norvegicus rhomboid, veinlet-like 2 (Drosophila) (Rhbdl2), transcript variant X1, mRNA","A2AGA4",528,0,"Rhomboid-related protein 2","MT0119",51.2,{"v":4e-06,"d":"4.00E-06"},"COG0705","pfam01694","Rhomboid","Rhomboid family. This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes.   Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease.4] (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.","GO:0006508|proteolysis;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004252|serine-type endopeptidase activity;","K02857","RHBDL1_2_3; rhomboid-related protein 1/2/3 [EC:3.4.21.105]"]
["ENSRNOG00000013902",62,5.216386656,14,0.900626135,5.79195568,2.534050563,1.27E-11,{"v":2.26e-11,"d":"2.26E-11"},"up","yes","P2ry12","protein_coding","chr2:143481430-143523361:-","gi|12248187|ref|NP_073637.1|",1689,0,"P2Y purinoceptor 12 [Rattus norvegicus]","gi|672042396|ref|XM_006232408.2|",2092,0,"PREDICTED: Rattus norvegicus purinergic receptor P2Y, G-protein coupled, 12 (P2ry12), transcript variant X3, mRNA","Q9EPX4",655,0,"P2Y purinoceptor 12",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001973|adenosine receptor signaling pathway;GO:0006930|substrate-dependent cell migration, cell extension;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007188|adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007193|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0008347|glial cell migration;GO:0010700|negative regulation of norepinephrine secretion;GO:0019722|calcium-mediated signaling;GO:0021808|cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration;GO:0030030|cell projection organization;GO:0030032|lamellipodium assembly;GO:0030168|platelet activation;GO:0033626|positive regulation of integrin activation by cell surface receptor linked signal transduction;GO:0033630|positive regulation of cell adhesion mediated by integrin;GO:0035585|calcium-mediated signaling using extracellular calcium source;GO:0035589|G protein-coupled purinergic nucleotide receptor signaling pathway;GO:0043270|positive regulation of ion transport;GO:0043491|protein kinase B signaling;GO:0045596|negative regulation of cell differentiation;GO:0048678|response to axon injury;GO:0050920|regulation of chemotaxis;GO:0050921|positive regulation of chemotaxis;GO:0051897|positive regulation of protein kinase B signaling;GO:0051924|regulation of calcium ion transport;GO:0070527|platelet aggregation;GO:0070588|calcium ion transmembrane transport;GO:0071318|cellular response to ATP;GO:0071407|cellular response to organic cyclic compound;GO:0071805|potassium ion transmembrane transport;GO:0150063|visual system development;GO:1900029|positive regulation of ruffle assembly;GO:1904139|regulation of microglial cell migration;GO:1904141|positive regulation of microglial cell migration;","GO:0005739|mitochondrion;GO:0005886|plasma membrane;GO:0005901|caveola;GO:0009897|external side of plasma membrane;GO:0009925|basal plasma membrane;GO:0016021|integral component of membrane;GO:0031224|intrinsic component of membrane;GO:0031253|cell projection membrane;GO:0044298|cell body membrane;","GO:0001609|G protein-coupled adenosine receptor activity;GO:0001621|ADP receptor activity;GO:0045028|G protein-coupled purinergic nucleotide receptor activity;","K04298","P2RY12; P2Y purinoceptor 12"]
["ENSRNOG00000010325",81,6.81495676,26,1.672591393,4.074489914,2.026619459,1.39E-11,{"v":2.46e-11,"d":"2.46E-11"},"up","yes","Ptger3","protein_coding","chr2:246606183-246684434:+","gi|564339401|ref|XP_006233597.1|",1635,0,"PREDICTED: prostaglandin E2 receptor EP3 subtype isoform X1 [Rattus norvegicus]","gi|672044548|ref|XM_006233535.2|",2115,0,"PREDICTED: Rattus norvegicus prostaglandin E receptor 3 (subtype EP3) (Ptger3), transcript variant X1, mRNA","P34980",625,0,"Prostaglandin E2 receptor EP3 subtype",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001660|fever generation;GO:0001934|positive regulation of protein phosphorylation;GO:0002029|desensitization of G protein-coupled receptor signaling pathway;GO:0006954|inflammatory response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007188|adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007565|female pregnancy;GO:0009410|response to xenobiotic stimulus;GO:0010628|positive regulation of gene expression;GO:0010700|negative regulation of norepinephrine secretion;GO:0010840|regulation of circadian sleep/wake cycle, wakefulness;GO:0014061|regulation of norepinephrine secretion;GO:0014827|intestine smooth muscle contraction;GO:0014832|urinary bladder smooth muscle contraction;GO:0015701|bicarbonate transport;GO:0031622|positive regulation of fever generation;GO:0031623|receptor internalization;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0032570|response to progesterone;GO:0035810|positive regulation of urine volume;GO:0043950|positive regulation of cAMP-mediated signaling;GO:0045907|positive regulation of vasoconstriction;GO:0046010|positive regulation of circadian sleep/wake cycle, non-REM sleep;GO:0046676|negative regulation of insulin secretion;GO:0060137|maternal process involved in parturition;GO:0060455|negative regulation of gastric acid secretion;GO:0071222|cellular response to lipopolysaccharide;GO:0071347|cellular response to interleukin-1;GO:0090331|negative regulation of platelet aggregation;GO:0106072|negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:1901380|negative regulation of potassium ion transmembrane transport;GO:1902074|response to salt;GO:1903170|negative regulation of calcium ion transmembrane transport;GO:1903640|negative regulation of gastrin-induced gastric acid secretion;GO:1904320|positive regulation of smooth muscle contraction involved in micturition;GO:1904322|cellular response to forskolin;GO:1904325|positive regulation of inhibitory G protein-coupled receptor phosphorylation;GO:1904326|negative regulation of circadian sleep/wake cycle, wakefulness;GO:1904330|positive regulation of myofibroblast contraction;GO:1904343|positive regulation of colon smooth muscle contraction;GO:1904346|positive regulation of gastric mucosal blood circulation;GO:1990767|prostaglandin receptor internalization;GO:2000391|positive regulation of neutrophil extravasation;GO:2000978|negative regulation of forebrain neuron differentiation;","GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0031526|brush border membrane;GO:0031965|nuclear membrane;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:1990769|proximal neuron projection;","GO:0004957|prostaglandin E receptor activity;","K04260","PTGER3; prostaglandin E receptor 3"]
["ENSRNOG00000031515",73,6.141874611,21,1.350939202,4.546373814,2.184716311,{"v":1.69e-11,"d":"1.69E-11"},{"v":2.99e-11,"d":"2.99E-11"},"up","yes","Klra2","protein_coding","chr4:164909969-164985338:-","gi|57222300|ref|NP_001009486.1|",1309,{"v":2E-167,"d":"2.00E-167"},"killer cell lectin-like receptor 2 [Rattus norvegicus]","gi|55250451|gb|BC085917.1|",3540,0,"Rattus norvegicus killer cell lectin-like receptor, subfamily A, member 2, mRNA (cDNA clone MGC:94821 IMAGE:7108565), complete cds","Q60660",283,{"v":4e-85,"d":"4.00E-85"},"Killer cell lectin-like receptor 2",".",".",".",".","pfam08391","Ly49","Ly49-like protein, N-terminal region. The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).","GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;",".","."]
["ENSRNOG00000000187",176,14.80780728,102,6.561704695,2.256701264,1.174215451,2.21E-11,{"v":3.85e-11,"d":"3.85E-11"},"up","yes","Csf2rb","protein_coding","chr7:109886425-109904157:+","gi|149066007|gb|EDM15880.1|",4115,0,"rCG59972 [Rattus norvegicus]","gi|19424231|ref|NM_133555.1|",2843,0,"Rattus norvegicus colony stimulating factor 2 receptor beta common subunit (Csf2rb), mRNA","P26955",1258,0,"Cytokine receptor common subunit beta",".",".",".",".","pfam09294","Interfer-bind","Interferon-alpha/beta receptor, fibronectin type III. Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.","GO:0019221|cytokine-mediated signaling pathway;GO:0032496|response to lipopolysaccharide;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0004896|cytokine receptor activity;","K04738","CSF2RB, IL3RB, CD131; cytokine receptor common subunit beta"]
["ENSRNOG00000016012",172,14.47126621,99,6.36871338,2.272243284,1.184117309,{"v":2.75e-11,"d":"2.75E-11"},{"v":4.76e-11,"d":"4.76E-11"},"up","yes","Spats2l","protein_coding","chr9:59320276-59493967:+","gi|148667641|gb|EDL00058.1|",3023,0,"RIKEN cDNA 2810022L02, isoform CRA_c, partial [Mus musculus]","gi|672065181|ref|XM_006244992.2|",2336,0,"PREDICTED: Rattus norvegicus spermatogenesis associated, serine-rich 2-like (Spats2l), transcript variant X3, mRNA","Q5U2T3",1115,0,"SPATS2-like protein",".",".",".",".","pfam07139","DUF1387","Protein of unknown function (DUF1387). This family represents a conserved region approximately 300 residues long within a number of hypothetical proteins of unknown function that seem to be restricted to mammals.",".","GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0032991|protein-containing complex;",".",".","."]
["ENSRNOG00000031598",69,5.805333537,19,1.222278326,4.749600329,2.247806118,{"v":2.75e-11,"d":"2.75E-11"},{"v":4.77e-11,"d":"4.77E-11"},"up","yes","Atp8b4","protein_coding","chr3:113556192-113757225:-","gi|564302296|ref|XP_006224667.1|",6228,0,"PREDICTED: probable phospholipid-transporting ATPase IM isoform X1 [Rattus norvegicus]","gi|672017295|ref|XM_006224605.2|",4416,0,"PREDICTED: Rattus norvegicus ATPase, class I, type 8B, member 4 (Atp8b4), transcript variant X1, mRNA","Q8TF62",2150,0,"Probable phospholipid-transporting ATPase IM",".",".",".",".","pfam00122","E1-E2_ATPase","E1-E2 ATPase.",".","GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0000287|magnesium ion binding;GO:0005524|ATP binding;","K01530","E7.6.2.1; phospholipid-translocating ATPase [EC:7.6.2.1]"]
["ENSRNOG00000003959",64,5.384657193,16,1.029287011,5.23144384,2.387209175,2.96E-11,{"v":5.11e-11,"d":"5.11E-11"},"up","yes","Rgs18","protein_coding","chr13:56494010-56516098:-","gi|149058439|gb|EDM09596.1|",1249,{"v":5e-170,"d":"5.00E-170"},"regulator of G-protein signaling 18 [Rattus norvegicus]","gi|672074059|ref|XM_008769548.1|",818,0,"PREDICTED: Rattus norvegicus regulator of G-protein signaling 18 (Rgs18), transcript variant X1, mRNA","Q4L0E8",484,{"v":5e-171,"d":"5.00E-171"},"Regulator of G-protein signaling 18",".",".",".",".","pfam00615","RGS","Regulator of G protein signaling domain. RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0008277|regulation of G protein-coupled receptor signaling pathway;GO:0009968|negative regulation of signal transduction;GO:0050790|regulation of catalytic activity;","GO:0005737|cytoplasm;","GO:0005096|GTPase activator activity;","K16449","RGS; regulator of G-protein signaling"]
["ENSRNOG00000014378",64,5.384657193,16,1.029287011,5.23144384,2.387209175,2.96E-11,{"v":5.11e-11,"d":"5.11E-11"},"up","yes","Il1r2","protein_coding","chr9:42384433-42424725:+","gi|672064768|ref|XP_008765205.1|",2198,0,"PREDICTED: interleukin-1 receptor type 2 isoform X2 [Rattus norvegicus]","gi|672064767|ref|XM_008766983.1|",1374,0,"PREDICTED: Rattus norvegicus interleukin 1 receptor, type II (Il1r2), transcript variant X1, mRNA","P43303",813,0,"Interleukin-1 receptor type 2",".",".",".",".","pfam13927","Ig_3","Immunoglobulin domain. This family contains immunoglobulin-like domains.","GO:0010955|negative regulation of protein processing;GO:0019221|cytokine-mediated signaling pathway;GO:0032690|negative regulation of interleukin-1 alpha production;GO:1900016|negative regulation of cytokine production involved in inflammatory response;GO:2000660|negative regulation of interleukin-1-mediated signaling pathway;","GO:0005576|extracellular region;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004908|interleukin-1 receptor activity;GO:0004910|interleukin-1, type II, blocking receptor activity;GO:0019966|interleukin-1 binding;","K04387","IL1R2, CD121b; interleukin 1 receptor type II"]
["ENSRNOG00000005404",72,6.057739343,21,1.350939202,4.48409472,2.164816753,{"v":3.01e-11,"d":"3.01E-11"},{"v":5.19e-11,"d":"5.19E-11"},"up","yes","Rasgrp1","protein_coding","chr3:104170013-104230056:-","gi|3237381|gb|AAC40137.1|",3661,0,"ras guanyl releasing protein [Rattus norvegicus]","gi|31377529|ref|NM_019211.2|",3118,0,"Rattus norvegicus RAS guanyl releasing protein 1 (Rasgrp1), mRNA","Q9R1K8",1414,0,"RAS guanyl-releasing protein 1",".",".",".",".","pfam00617","RasGEF","RasGEF domain. Guanine nucleotide exchange factor for Ras-like small GTPases.","GO:0001934|positive regulation of protein phosphorylation;GO:0002437|inflammatory response to antigenic stimulus;GO:0007264|small GTPase mediated signal transduction;GO:0014066|regulation of phosphatidylinositol 3-kinase signaling;GO:0030101|natural killer cell activation;GO:0030154|cell differentiation;GO:0032252|secretory granule localization;GO:0032725|positive regulation of granulocyte macrophage colony-stimulating factor production;GO:0032729|positive regulation of interferon-gamma production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032816|positive regulation of natural killer cell activation;GO:0032825|positive regulation of natural killer cell differentiation;GO:0033089|positive regulation of T cell differentiation in thymus;GO:0042098|T cell proliferation;GO:0042100|B cell proliferation;GO:0042110|T cell activation;GO:0042113|B cell activation;GO:0043303|mast cell degranulation;GO:0043406|positive regulation of MAP kinase activity;GO:0043547|positive regulation of GTPase activity;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;GO:0046330|positive regulation of JNK cascade;GO:0046579|positive regulation of Ras protein signal transduction;GO:0047496|vesicle transport along microtubule;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0090630|activation of GTPase activity;","GO:0000139|Golgi membrane;GO:0005789|endoplasmic reticulum membrane;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0005509|calcium ion binding;GO:0008270|zinc ion binding;GO:0019992|diacylglycerol binding;GO:0031210|phosphatidylcholine binding;GO:0042802|identical protein binding;","K04350","RASGRP1; RAS guanyl-releasing protein 1"]
["ENSRNOG00000013829",37,3.11300494,2,0.128660876,24.19542776,4.59666254,{"v":3.19e-11,"d":"3.19E-11"},{"v":5.49e-11,"d":"5.49E-11"},"up","yes","Chrna3","protein_coding","chr8:55401702-55415165:-","gi|113061|sp|P04757.1|ACHA3_RAT",2365,0,"RecName: Full=Neuronal acetylcholine receptor subunit alpha-3; Flags: Precursor","gi|55583|emb|X03440.1|",1907,0,"Rat mRNA for neuronal acetylcholine receptor alpha-3 chain subunit","P04757",913,0,"Neuronal acetylcholine receptor subunit alpha-3",".",".",".",".","pfam02931","Neur_chan_LBD","Neurotransmitter-gated ion-channel ligand binding domain. This family is the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.","GO:0006937|regulation of muscle contraction;GO:0006940|regulation of smooth muscle contraction;GO:0007165|signal transduction;GO:0007171|activation of transmembrane receptor protein tyrosine kinase activity;GO:0007268|chemical synaptic transmission;GO:0007271|synaptic transmission, cholinergic;GO:0007399|nervous system development;GO:0007507|heart development;GO:0007626|locomotory behavior;GO:0009410|response to xenobiotic stimulus;GO:0010035|response to inorganic substance;GO:0014056|regulation of acetylcholine secretion, neurotransmission;GO:0034220|ion transmembrane transport;GO:0035094|response to nicotine;GO:0035095|behavioral response to nicotine;GO:0042391|regulation of membrane potential;GO:0048814|regulation of dendrite morphogenesis;GO:0050877|nervous system process;GO:0060079|excitatory postsynaptic potential;GO:0060084|synaptic transmission involved in micturition;GO:0095500|acetylcholine receptor signaling pathway;GO:1905144|response to acetylcholine;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0005887|integral component of plasma membrane;GO:0005892|acetylcholine-gated channel complex;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0030425|dendrite;GO:0032991|protein-containing complex;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0044853|plasma membrane raft;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0098691|dopaminergic synapse;GO:0098981|cholinergic synapse;GO:0099060|integral component of postsynaptic specialization membrane;","GO:0015464|acetylcholine receptor activity;GO:0022848|acetylcholine-gated cation-selective channel activity;GO:0030594|neurotransmitter receptor activity;GO:0042166|acetylcholine binding;GO:0044877|protein-containing complex binding;GO:1901363|heterocyclic compound binding;GO:1904315|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K04805","CHRNA3; nicotinic acetylcholine receptor alpha-3"]
["ENSRNOG00000019270",160,13.46164298,89,5.725408998,2.351210715,1.233403839,{"v":3.28e-11,"d":"3.28E-11"},5.64E-11,"up","yes","P2ry6","protein_coding","chr1:155295111-155330808:-","gi|16923974|ref|NP_476465.1|",1481,0,"P2Y purinoceptor 6 [Rattus norvegicus]","gi|48675856|ref|NM_057124.2|",2465,0,"Rattus norvegicus pyrimidinergic receptor P2Y6 (P2ry6), mRNA","Q63371",575,0,"P2Y purinoceptor 6",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0006909|phagocytosis;GO:0007186|G protein-coupled receptor signaling pathway;GO:0014911|positive regulation of smooth muscle cell migration;GO:0030321|transepithelial chloride transport;GO:0031587|positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity;GO:0032962|positive regulation of inositol trisphosphate biosynthetic process;GO:0035589|G protein-coupled purinergic nucleotide receptor signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071380|cellular response to prostaglandin E stimulus;GO:0071407|cellular response to organic cyclic compound;GO:0071415|cellular response to purine-containing compound;GO:1904707|positive regulation of vascular smooth muscle cell proliferation;GO:1905835|cellular response to pyrimidine ribonucleotide;","GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;","GO:0001621|ADP receptor activity;GO:0045029|UDP-activated nucleotide receptor activity;GO:0045030|UTP-activated nucleotide receptor activity;","K04272","P2RY6; P2Y purinoceptor 6"]
["ENSRNOG00000062686",204,17.1635948,128,8.234296088,2.084403405,1.059634517,{"v":3.32e-11,"d":"3.32E-11"},{"v":5.7e-11,"d":"5.70E-11"},"up","yes","Gcnt1","protein_coding","chr1:214718293-214758776:-","gi|11560101|ref|NP_071612.1|",2283,0,"beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase [Rattus norvegicus]","gi|672039927|ref|XM_006231147.2|",4505,0,"PREDICTED: Rattus norvegicus glucosaminyl (N-acetyl) transferase 1, core 2 (Gcnt1), transcript variant X1, mRNA","Q09324",836,0,"Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase",".",".",".",".","pfam02485","Branch","Core-2/I-Branching enzyme. This is a family of two different beta-1,6-N-acetylglucosaminyltransferase enzymes, I-branching enzyme and core-2 branching enzyme. I-branching enzyme is responsible for the production of the blood group I-antigen during embryonic development. Core-2 branching enzyme forms crucial side-chain branches in O-glycans.",".",".",".",".","."]
["ENSRNOG00000002158",55,4.627439776,11,0.70763482,6.5393048,2.70913727,{"v":3.72e-11,"d":"3.72E-11"},{"v":6.37e-11,"d":"6.37E-11"},"up","yes","Ibsp","protein_coding","chr14:5439829-5452693:-","gi|149046722|gb|EDL99496.1|",1122,{"v":9e-145,"d":"9.00E-145"},"integrin binding sialoprotein, isoform CRA_a [Rattus norvegicus]","gi|158303313|ref|NM_012587.2|",1930,0,"Rattus norvegicus integrin-binding sialoprotein (Ibsp), mRNA","P13839",370,{"v":6e-121,"d":"6.00E-121"},"Bone sialoprotein 2",".",".",".",".","pfam05432","BSP_II","Bone sialoprotein II (BSP-II). Bone sialoprotein (BSP) is a major structural protein of the bone matrix that is specifically expressed by fully-differentiated osteoblasts. The expression of bone sialoprotein (BSP) is normally restricted to mineralised connective tissues of bones and teeth where it has been associated with mineral crystal formation. However, it has been found that ectopic expression of BSP occurs in various lesions, including oral and extraoral carcinomas, in which it has been associated with the formation of microcrystalline deposits and the metastasis of cancer cells to bone.","GO:0001503|ossification;GO:0007155|cell adhesion;GO:0007229|integrin-mediated signaling pathway;GO:0030198|extracellular matrix organization;GO:0030282|bone mineralization;GO:0045785|positive regulation of cell adhesion;GO:0071363|cellular response to growth factor stimulus;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0031012|extracellular matrix;GO:0031982|vesicle;","GO:0005178|integrin binding;","K06253","IBSP; integrin binding sialoprotein"]
["ENSRNOG00000036674",55,4.627439776,11,0.70763482,6.5393048,2.70913727,{"v":3.72e-11,"d":"3.72E-11"},{"v":6.37e-11,"d":"6.37E-11"},"up","yes","Cd7","protein_coding","chr10:106304056-106306967:-","gi|157819011|ref|NP_001100544.1|",1010,{"v":6e-135,"d":"6.00E-135"},"T-cell antigen CD7 precursor [Rattus norvegicus]","gi|298887746|emb|FQ233656.1|",971,0,"Rattus norvegicus TL0AEA60YP20 mRNA sequence","P50283",320,{"v":1E-107,"d":"1.00E-107"},"T-cell antigen CD7",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0002250|adaptive immune response;GO:0048873|homeostasis of number of cells within a tissue;","GO:0016021|integral component of membrane;","GO:0038023|signaling receptor activity;","K06457","CD7; T-cell surface glycoprotein CD7"]
["ENSRNOG00000052080",156,13.12510191,86,5.532417684,2.372398951,1.246346639,{"v":4e-11,"d":"4.00E-11"},{"v":6.84e-11,"d":"6.84E-11"},"up","yes","Camk2b","protein_coding","chr14:80845238-80933994:-","gi|532046912|ref|XP_005366245.1|",3059,0,"PREDICTED: calcium/calmodulin-dependent protein kinase type II subunit beta isoform X5 [Microtus ochrogaster]","gi|755536160|ref|XM_006514465.2|",3340,0,"PREDICTED: Mus musculus calcium/calmodulin-dependent protein kinase II, beta (Camk2b), transcript variant X3, mRNA","Q13554",1172,0,"Calcium/calmodulin-dependent protein kinase type II subunit beta",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0000082|G1/S transition of mitotic cell cycle;GO:0002030|inhibitory G protein-coupled receptor phosphorylation;GO:0006468|protein phosphorylation;GO:0006816|calcium ion transport;GO:0010976|positive regulation of neuron projection development;GO:0018105|peptidyl-serine phosphorylation;GO:0032222|regulation of synaptic transmission, cholinergic;GO:0032430|positive regulation of phospholipase A2 activity;GO:0046686|response to cadmium ion;GO:0046777|protein autophosphorylation;GO:0048169|regulation of long-term neuronal synaptic plasticity;GO:0048858|cell projection morphogenesis;GO:0050885|neuromuscular process controlling balance;GO:0060291|long-term synaptic potentiation;GO:0060466|activation of meiosis involved in egg activation;GO:0061003|positive regulation of dendritic spine morphogenesis;GO:0090129|positive regulation of synapse maturation;GO:0098974|postsynaptic actin cytoskeleton organization;GO:0110088|hippocampal neuron apoptotic process;GO:1903076|regulation of protein localization to plasma membrane;GO:1905375|cellular response to homocysteine;GO:1990911|response to psychosocial stress;GO:2001222|regulation of neuron migration;GO:2001235|positive regulation of apoptotic signaling pathway;","GO:0005737|cytoplasm;GO:0005815|microtubule organizing center;GO:0005829|cytosol;GO:0005954|calcium- and calmodulin-dependent protein kinase complex;GO:0014069|postsynaptic density;GO:0030425|dendrite;GO:0033017|sarcoplasmic reticulum membrane;GO:0043005|neuron projection;GO:0043204|perikaryon;GO:0051233|spindle midzone;GO:0098978|glutamatergic synapse;","GO:0004674|protein serine/threonine kinase activity;GO:0004683|calmodulin-dependent protein kinase activity;GO:0005515|protein binding;GO:0005516|calmodulin binding;GO:0005524|ATP binding;GO:0019901|protein kinase binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0043274|phospholipase binding;GO:0098973|structural constituent of postsynaptic actin cytoskeleton;","K04515","CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]"]
["ENSRNOG00000007243",53,4.459169238,10,0.643304382,6.931663088,2.793201534,{"v":4.16e-11,"d":"4.16E-11"},{"v":7.1E-11,"d":"7.10E-11"},"up","yes","Havcr1","protein_coding","chr10:31119088-31151698:+","gi|564371506|ref|XP_006246225.1|",1275,{"v":8e-169,"d":"8.00E-169"},"PREDICTED: hepatitis A virus cellular receptor 1 homolog isoform X1 [Rattus norvegicus]","gi|672067240|ref|XM_006246163.2|",1961,0,"PREDICTED: Rattus norvegicus hepatitis A virus cellular receptor 1 (Havcr1), transcript variant X1, mRNA","O54947",476,{"v":8e-163,"d":"8.00E-163"},"Hepatitis A virus cellular receptor 1 homolog",".",".",".",".","pfam11465","Receptor_2B4","Natural killer cell receptor 2B4. 2B4 is a transmembrane receptor which is expressed primarily on natural killer cells. It plays a role in activating NK-mediated cytotoxicity through its interaction with CD48 on target cells in a subset of CD8 T cells. The structure of 2B4 consists of an immunoglobulin variable domain fold and contains two beta-sheets. One of the beta-sheets, the six-stranded sheet, contains structural features that may have a role in ligand recognition and receptor function.","GO:0006911|phagocytosis, engulfment;GO:0007584|response to nutrient;GO:0009410|response to xenobiotic stimulus;GO:0009611|response to wounding;GO:0010046|response to mycotoxin;GO:0032496|response to lipopolysaccharide;GO:0033005|positive regulation of mast cell activation;GO:0033574|response to testosterone;GO:0046677|response to antibiotic;GO:0046718|viral entry into host cell;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005903|brush border;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0031514|motile cilium;GO:0045335|phagocytic vesicle;","GO:0001618|virus receptor activity;GO:0001786|phosphatidylserine binding;GO:0003674|molecular_function;","K20413","HAVCR1, CD365; hepatitis A virus cellular receptor 1"]
["ENSRNOG00000015159",35,2.944734403,0,0.032165219,91.55026721,6.516492192,{"v":5.31e-11,"d":"5.31E-11"},{"v":9e-11,"d":"9.00E-11"},"up","yes","Slc9a3","protein_coding","chr1:29124674-29167417:-","gi|672034078|ref|XP_008756899.1|",4109,0,"PREDICTED: sodium/hydrogen exchanger 3 isoform X1 [Rattus norvegicus]","gi|6981561|ref|NM_012654.1|",5110,0,"Rattus norvegicus solute carrier family 9 member A3 (Slc9a3), mRNA","P26433",1585,0,"Sodium/hydrogen exchanger 3","SPAC15A10.06",140,{"v":1e-33,"d":"1.00E-33"},"COG0025","pfam00999","Na_H_Exchanger","Sodium/hydrogen exchanger family. Na/H antiporters are key transporters in maintaining the pH of actively metabolizing cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.","GO:0002028|regulation of sodium ion transport;GO:0006814|sodium ion transport;GO:0006885|regulation of pH;GO:0006898|receptor-mediated endocytosis;GO:0007623|circadian rhythm;GO:0051384|response to glucocorticoid;GO:0051453|regulation of intracellular pH;GO:0071805|potassium ion transmembrane transport;GO:0098656|anion transmembrane transport;GO:0098719|sodium ion import across plasma membrane;GO:1902600|proton transmembrane transport;","GO:0005886|plasma membrane;GO:0005903|brush border;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0031526|brush border membrane;GO:0031982|vesicle;GO:0070062|extracellular exosome;","GO:0005515|protein binding;GO:0015385|sodium:proton antiporter activity;GO:0015386|potassium:proton antiporter activity;GO:0030165|PDZ domain binding;","K12040","SLC9A3, NHE3; solute carrier family 9 (sodium/hydrogen exchanger), member 3"]
["ENSRNOG00000008798",66,5.552927731,18,1.157947887,4.795490187,2.261678293,{"v":6.27e-11,"d":"6.27E-11"},1.06E-10,"up","yes","Pipox","protein_coding","chr10:62769900-62782370:-","gi|58865586|ref|NP_001012009.1|",2097,0,"peroxisomal sarcosine oxidase [Rattus norvegicus]","gi|564373368|ref|XM_006246958.1|",1666,0,"PREDICTED: Rattus norvegicus pipecolic acid oxidase (Pipox), transcript variant X1, mRNA","Q9D826",756,0,"Peroxisomal sarcosine oxidase","STM1160",171,{"v":2E-46,"d":"2.00E-46"},"COG0665","pfam01266","DAO","FAD dependent oxidoreductase. This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.","GO:0033514|L-lysine catabolic process to acetyl-CoA via L-pipecolate;GO:0046653|tetrahydrofolate metabolic process;","GO:0005777|peroxisome;","GO:0008115|sarcosine oxidase activity;GO:0050031|L-pipecolate oxidase activity;","K00306","PIPOX; sarcosine oxidase / L-pipecolate oxidase [EC:1.5.3.1 1.5.3.7]"]
["ENSRNOG00000008915",52,4.37503397,10,0.643304382,6.800876992,2.765720798,{"v":7.91e-11,"d":"7.91E-11"},{"v":1.32e-10,"d":"1.32E-10"},"up","yes","Prima1","protein_coding","chr6:122338370-122389921:-","gi|672056787|ref|XP_008763071.1|",877,{"v":3e-106,"d":"3.00E-106"},"PREDICTED: proline-rich membrane anchor 1 isoform X2 [Rattus norvegicus]","gi|672056786|ref|XM_008764849.1|",3518,0,"PREDICTED: Rattus norvegicus proline rich membrane anchor 1 (Prima1), transcript variant X1, mRNA","D3ZZP4",251,{"v":2e-75,"d":"2.00E-75"},"Proline-rich membrane anchor 1",".",".",".",".","pfam02500","DNA_pack_N","Probable DNA packing protein, N-terminus. This family includes proteins that are probably involved in DNA packing in herpesvirus. This domain is normally found at the N-terminus of the protein.","GO:0042135|neurotransmitter catabolic process;GO:0051649|establishment of localization in cell;","GO:0016021|integral component of membrane;GO:0031226|intrinsic component of plasma membrane;GO:0045202|synapse;","GO:0019899|enzyme binding;GO:0043495|protein membrane anchor;",".","."]
["ENSRNOG00000052803",40,3.365410746,4,0.257321753,13.0786096,3.70913727,{"v":8.32e-11,"d":"8.32E-11"},{"v":1.39e-10,"d":"1.39E-10"},"up","yes","Klri1","protein_coding","chr4:163183669-163218870:-","gi|60593099|ref|NP_001012667.1|",1237,{"v":3e-168,"d":"3.00E-168"},"killer cell lectin-like receptor family I member 1 [Rattus norvegicus]","gi|298888087|emb|FQ233804.1|",1126,0,"Rattus norvegicus TL0AEA60YF14 mRNA sequence","Q5DT39",481,{"v":9E-170,"d":"9.00E-170"},"Killer cell lectin-like receptor subfamily I member 1",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type",".","GO:0005887|integral component of plasma membrane;","GO:0030246|carbohydrate binding;",".","."]
["ENSRNOG00000015411",147,12.36788449,80,5.146435055,2.403194514,1.264953425,{"v":8.85e-11,"d":"8.85E-11"},{"v":1.47e-10,"d":"1.47E-10"},"up","yes","Apobec1","protein_coding","chr4:155800887-155827390:-","gi|148667274|gb|EDK99690.1|",1139,{"v":3e-150,"d":"3.00E-150"},"apolipoprotein B editing complex 1, isoform CRA_b, partial [Mus musculus]","gi|672050786|ref|XM_006237290.2|",898,0,"PREDICTED: Rattus norvegicus apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 (Apobec1), transcript variant X2, mRNA","P38483",473,{"v":1e-163,"d":"1.00E-163"},"C->U-editing enzyme APOBEC-1",".",".",".",".","pfam08210","APOBEC_N","APOBEC-like N-terminal domain. A mechanism of generating protein diversity is mRNA editing. Members of this family are C-to-U editing enzymes. The N-terminal domain of APOBEC-1 like proteins is the catalytic domain, while the C-terminal domain is a pseudocatalyitc domain. More specifically, the catalytic domain is a zinc dependent deaminases domain and is essential for cytidine deamination.APOBEC-3 like members contain two copies of this domain. RNA editing by APOBEC-1 requires homodimerization and this complex interacts with RNA binding proteins to from the editosome (and references therein). This family also includes the functionally homologous activation induced deaminase (AID), which is essential for the development of antibody diversity in B lymphocytes, and the sea lamprey PmCDA1 and PmCDA2, which are predicted to play an AID-like role in the adaptive immune response of jawless vertebrates. Divergent members of this family are present in various eukaryotes such as Nematostella, C. elegans, Micromonas and Emiliania, and prokaryotes such as Wolbachia and Pseudomonas brassicacearum.","GO:0006397|mRNA processing;GO:0006641|triglyceride metabolic process;GO:0006970|response to osmotic stress;GO:0009410|response to xenobiotic stimulus;GO:0009972|cytidine deamination;GO:0010043|response to zinc ion;GO:0010332|response to gamma radiation;GO:0016554|cytidine to uridine editing;GO:0016556|mRNA modification;GO:0032869|cellular response to insulin stimulus;GO:0042127|regulation of cell proliferation;GO:0042157|lipoprotein metabolic process;GO:0042158|lipoprotein biosynthetic process;GO:0042953|lipoprotein transport;GO:0045471|response to ethanol;GO:0046087|cytidine metabolic process;GO:0048255|mRNA stabilization;GO:0050790|regulation of catalytic activity;GO:0051592|response to calcium ion;GO:0051607|defense response to virus;GO:0070383|DNA cytosine deamination;GO:0080111|DNA demethylation;GO:0090209|negative regulation of triglyceride metabolic process;GO:0090310|negative regulation of methylation-dependent chromatin silencing;GO:0090366|positive regulation of mRNA modification;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0003723|RNA binding;GO:0003729|mRNA binding;GO:0004126|cytidine deaminase activity;GO:0004131|cytosine deaminase activity;GO:0005515|protein binding;GO:0008047|enzyme activator activity;GO:0008270|zinc ion binding;GO:0019904|protein domain specific binding;GO:0035925|mRNA 3'-UTR AU-rich region binding;GO:0043021|ribonucleoprotein complex binding;","K16932","APOBEC1; C->U-editing enzyme APOBEC1 [EC:3.5.4.36]"]
["ENSRNOG00000025848",114,9.591420626,53,3.409513224,2.813134895,1.492178734,9.35E-11,1.56E-10,"up","yes","Sspo","protein_coding","chr4:77397059-77450412:+","gi|55741770|ref|NP_001007017.1|",24046,0,"SCO-spondin precursor [Rattus norvegicus]","gi|55741769|ref|NM_001007016.1|",15558,0,"Rattus norvegicus SCO-spondin (Sspo), mRNA","Q700K0",9267,0,"SCO-spondin",".",".",".",".","pfam00094","VWD","von Willebrand factor type D domain. Luciferin-2-monooxygenase from Vargula hilgendorfii contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.","GO:0007155|cell adhesion;GO:0007399|nervous system development;GO:0030154|cell differentiation;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0031012|extracellular matrix;",".","K24434","SSPO; SCO-spondin"]
["ENSRNOG00000003066",73,6.141874611,23,1.479600078,4.15103696,2.053471778,{"v":9.7e-11,"d":"9.70E-11"},{"v":1.61e-10,"d":"1.61E-10"},"up","yes","Wnt9a","protein_coding","chr10:44094140-44121133:+","gi|21314846|ref|NP_647459.1|",1652,0,"protein Wnt-9a precursor [Mus musculus]","gi|672067726|ref|XM_006246448.2|",3342,0,"PREDICTED: Rattus norvegicus wingless-type MMTV integration site family, member 9A (Wnt9a), transcript variant X1, mRNA","Q8R5M2",640,0,"Protein Wnt-9a",".",".",".",".","pfam00110","wnt","wnt family. Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.","GO:0008150|biological_process;GO:0008285|negative regulation of cell proliferation;GO:0030182|neuron differentiation;GO:0032331|negative regulation of chondrocyte differentiation;GO:0035115|embryonic forelimb morphogenesis;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045165|cell fate commitment;GO:0045597|positive regulation of cell differentiation;GO:0045880|positive regulation of smoothened signaling pathway;GO:0048704|embryonic skeletal system morphogenesis;GO:0048856|anatomical structure development;GO:0060070|canonical Wnt signaling pathway;GO:0060548|negative regulation of cell death;GO:0061037|negative regulation of cartilage development;","GO:0005575|cellular_component;GO:0005615|extracellular space;","GO:0003674|molecular_function;GO:0005109|frizzled binding;GO:0005125|cytokine activity;GO:0048018|receptor ligand activity;","K01064","WNT9; wingless-type MMTV integration site family, member 9"]
["ENSRNOG00000066902",83,6.983227298,30,1.929913146,3.618415323,1.85535801,{"v":1.1e-10,"d":"1.10E-10"},{"v":1.82e-10,"d":"1.82E-10"},"up","yes","ENSRNOG00000066902","pseudogene","chr10:91870520-91871959:+","gi|70794784|ref|NP_001020571.1|",922,{"v":2E-119,"d":"2.00E-119"},"survival of motor neuron-related-splicing factor 30 [Rattus norvegicus]","gi|672025356|ref|XM_008775413.1|",1352,0,"PREDICTED: Rattus norvegicus hypothetical LOC100363406 (LOC100363406), transcript variant X1, mRNA","Q4QQU6",359,{"v":7e-121,"d":"7.00E-121"},"Survival of motor neuron-related-splicing factor 30",".",".",".",".","pfam06003","SMN","Survival motor neuron protein (SMN). This family consists of several eukaryotic survival motor neuron (SMN) proteins. The Survival of Motor Neurons (SMN) protein, the product of the spinal muscular atrophy-determining gene, is part of a large macromolecular complex (SMN complex) that functions in the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs). The SMN complex functions as a specificity factor essential for the efficient assembly of Sm proteins on U snRNAs and likely protects cells from illicit, and potentially deleterious, non-specific binding of Sm proteins to RNAs.",".",".",".",".","."]
["ENSRNOG00000021067",65,5.468792462,18,1.157947887,4.722831245,2.239651986,1.13E-10,1.87E-10,"up","yes","Fxyd7","protein_coding","chr1:86277678-86286954:-","gi|149056255|gb|EDM07686.1|",401,{"v":1E-46,"d":"1.00E-46"},"FXYD domain-containing ion transport regulator 7 [Rattus norvegicus]","gi|672035858|ref|XM_006228843.2|",448,0,"PREDICTED: Rattus norvegicus FXYD domain-containing ion transport regulator 7 (Fxyd7), transcript variant X1, mRNA","P59648",95.5,{"v":1e-23,"d":"1.00E-23"},"FXYD domain-containing ion transport regulator 7",".",".",".",".","pfam02038","ATP1G1_PLM_MAT8","ATP1G1/PLM/MAT8 family.","GO:0006811|ion transport;GO:0043269|regulation of ion transport;GO:2000649|regulation of sodium ion transmembrane transporter activity;","GO:0016021|integral component of membrane;","GO:0017080|sodium channel regulator activity;GO:0051117|ATPase binding;","K13364","FXYD7; FXYD domain-containing ion transport regulator 7"]
["ENSRNOG00000063314",166,13.9664546,97,6.240052504,2.238195045,1.162335764,1.15E-10,{"v":1.9e-10,"d":"1.90E-10"},"up","yes","Utp23","protein_coding","chr7:83189656-83196655:+","gi|187282097|ref|NP_001119738.1|",1163,{"v":1e-149,"d":"1.00E-149"},"rRNA-processing protein UTP23 homolog [Rattus norvegicus]","gi|187282096|ref|NM_001126266.1|",985,0,"Rattus norvegicus UTP23, small subunit processome component (Utp23), mRNA","Q9CX11",424,{"v":4e-140,"d":"4.00E-140"},"rRNA-processing protein UTP23 homolog","SPCC18.12c",101,{"v":2e-22,"d":"2.00E-22"},"COG1412","pfam04900","Fcf1","Fcf1. Fcf1 is a nucleolar protein involved in pre-rRNA processing. Depletion of yeast Fcf1 and Fcf2 leads to a decrease in synthesis of the 18S rRNA and results in a deficit in 40S ribosomal subunits.",".",".",".",".","."]
["ENSRNOG00000068909",35,2.944734403,2,0.128660876,22.8875668,4.516492192,1.26E-10,{"v":2.08e-10,"d":"2.08E-10"},"up","yes","Cyp11b1","protein_coding","chr7:106718274-106779278:-","gi|303794|dbj|BAA00988.1|",2467,0,"cytochrome P-450-11beta [Rattus norvegicus]","gi|672059626|ref|XM_003750363.3|",1514,0,"PREDICTED: Rattus norvegicus cytochrome P450 11B1, mitochondrial-like (LOC100910462), transcript variant X1, mRNA","P15393",950,0,"Cytochrome P450 11B1, mitochondrial","alr4833",86.7,{"v":8e-17,"d":"8.00E-17"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.",".",".",".",".","."]
["ENSRNOG00000008170",139,11.69480234,74,4.760452426,2.456657749,1.296696882,1.28E-10,{"v":2.12e-10,"d":"2.12E-10"},"up","yes","Jph2","protein_coding","chr3:151994778-152058904:-","gi|83816931|ref|NP_001033063.1|",2615,0,"junctophilin-2 [Rattus norvegicus]","gi|672048005|ref|XM_006235526.2|",4169,0,"PREDICTED: Rattus norvegicus junctophilin 2 (Jph2), transcript variant X1, mRNA","Q2PS20",1011,0,"Junctophilin-2",".",".",".",".","pfam02493","MORN","MORN repeat. The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22).  #=GF CC   A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesised to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0045892|negative regulation of transcription, DNA-templated;GO:0055024|regulation of cardiac muscle tissue development;GO:0055074|calcium ion homeostasis;GO:0060316|positive regulation of ryanodine-sensitive calcium-release channel activity;","GO:0005634|nucleus;GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016529|sarcoplasmic reticulum;GO:0030018|Z disc;GO:0030314|junctional membrane complex;GO:0033017|sarcoplasmic reticulum membrane;","GO:0001046|core promoter sequence-specific DNA binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001786|phosphatidylserine binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;GO:0010314|phosphatidylinositol-5-phosphate binding;GO:0032266|phosphatidylinositol-3-phosphate binding;GO:0070273|phosphatidylinositol-4-phosphate binding;GO:0070300|phosphatidic acid binding;GO:0080025|phosphatidylinositol-3,5-bisphosphate binding;","K19530","JPH; junctophilin"]
["ENSRNOG00000009446",201,16.911189,129,8.298626526,2.037829868,1.02703361,{"v":1.4e-10,"d":"1.40E-10"},{"v":2.3e-10,"d":"2.30E-10"},"up","yes","Rxra","protein_coding","chr3:10989832-11073712:+","gi|148747360|ref|NP_036937.2|",2152,0,"retinoic acid receptor RXR-alpha [Rattus norvegicus]","gi|206818|gb|L06482.1|RATRXRA",1915,0,"Rat retinoid X receptor alpha mRNA, complete cds","Q05343",830,0,"Retinoic acid receptor RXR-alpha",".",".",".",".","pfam00104","Hormone_recep","Ligand-binding domain of nuclear hormone receptor. This all helical domain is involved in binding the hormone in these receptors.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001701|in utero embryonic development;GO:0001889|liver development;GO:0001890|placenta development;GO:0001893|maternal placenta development;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006954|inflammatory response;GO:0007494|midgut development;GO:0007507|heart development;GO:0007565|female pregnancy;GO:0007566|embryo implantation;GO:0007568|aging;GO:0007584|response to nutrient;GO:0008285|negative regulation of cell proliferation;GO:0010269|response to selenium ion;GO:0014070|response to organic cyclic compound;GO:0030154|cell differentiation;GO:0031103|axon regeneration;GO:0031641|regulation of myelination;GO:0032526|response to retinoic acid;GO:0032869|cellular response to insulin stimulus;GO:0033189|response to vitamin A;GO:0033280|response to vitamin D;GO:0035357|peroxisome proliferator activated receptor signaling pathway;GO:0043010|camera-type eye development;GO:0043065|positive regulation of apoptotic process;GO:0043401|steroid hormone mediated signaling pathway;GO:0045471|response to ethanol;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0045994|positive regulation of translational initiation by iron;GO:0048384|retinoic acid receptor signaling pathway;GO:0048856|anatomical structure development;GO:0051384|response to glucocorticoid;GO:0055010|ventricular cardiac muscle tissue morphogenesis;GO:0055012|ventricular cardiac muscle cell differentiation;GO:0060038|cardiac muscle cell proliferation;GO:0060528|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development;GO:0060687|regulation of branching involved in prostate gland morphogenesis;GO:1901522|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005739|mitochondrion;GO:0030424|axon;GO:0043235|receptor complex;GO:0090575|RNA polymerase II transcription factor complex;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001162|RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding;GO:0001972|retinoic acid binding;GO:0003677|DNA binding;GO:0003690|double-stranded DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0003707|steroid hormone receptor activity;GO:0004879|nuclear receptor activity;GO:0005515|protein binding;GO:0008270|zinc ion binding;GO:0016922|nuclear receptor binding;GO:0019899|enzyme binding;GO:0019904|protein domain specific binding;GO:0031490|chromatin DNA binding;GO:0042277|peptide binding;GO:0042802|identical protein binding;GO:0042809|vitamin D receptor binding;GO:0042974|retinoic acid receptor binding;GO:0043565|sequence-specific DNA binding;GO:0044323|retinoic acid-responsive element binding;GO:0044877|protein-containing complex binding;GO:0050692|DBD domain binding;GO:0050693|LBD domain binding;GO:0070644|vitamin D response element binding;GO:1990837|sequence-specific double-stranded DNA binding;","K08524","RXRA, NR2B1; retinoid X receptor alpha"]
["ENSRNOG00000066332",33,2.776463865,1,0.064330438,43.15941168,5.431603294,{"v":1.46e-10,"d":"1.46E-10"},{"v":2.4E-10,"d":"2.40E-10"},"up","yes","ENSRNOG00000066332","protein_coding","chr17:45117812-45180027:+","gi|149029254|gb|EDL84521.1|",1389,{"v":2E-180,"d":"2.00E-180"},"rCG23113, isoform CRA_a [Rattus norvegicus]","gi|755544276|ref|XM_006516705.2|",1606,0,"PREDICTED: Mus musculus G protein-coupled receptor 141 (Gpr141), transcript variant X7, mRNA","Q7TQP0",510,{"v":1e-170,"d":"1.00E-170"},"Probable G-protein coupled receptor 141",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.",".",".",".",".","."]
["ENSRNOG00000008868",203,17.07945954,131,8.427287402,2.026685305,1.01912209,{"v":1.48e-10,"d":"1.48E-10"},{"v":2.43e-10,"d":"2.43E-10"},"up","yes","Dusp19","protein_coding","chr3:65538420-65553534:+","gi|219275548|ref|NP_001101209.2|",929,{"v":2e-114,"d":"2.00E-114"},"dual specificity protein phosphatase 19 [Rattus norvegicus]","gi|219275547|ref|NM_001107739.2|",558,0,"Rattus norvegicus dual specificity phosphatase 19 (Dusp19), mRNA","Q8K4T5",331,{"v":2e-104,"d":"2.00E-104"},"Dual specificity protein phosphatase 19","YIR026c",69.3,{"v":2e-11,"d":"2.00E-11"},"COG2453","pfam00782","DSPc","Dual specificity phosphatase, catalytic domain. Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a \"recognition\" region.","GO:0006469|negative regulation of protein kinase activity;GO:0006470|protein dephosphorylation;GO:0007254|JNK cascade;GO:0008150|biological_process;GO:0032147|activation of protein kinase activity;GO:0043405|regulation of MAP kinase activity;GO:0043409|negative regulation of MAPK cascade;GO:0043410|positive regulation of MAPK cascade;GO:0043507|positive regulation of JUN kinase activity;GO:0043508|negative regulation of JUN kinase activity;GO:0045860|positive regulation of protein kinase activity;GO:0046329|negative regulation of JNK cascade;GO:0046330|positive regulation of JNK cascade;","GO:0005575|cellular_component;GO:0005737|cytoplasm;","GO:0003674|molecular_function;GO:0004860|protein kinase inhibitor activity;GO:0005078|MAP-kinase scaffold activity;GO:0008138|protein tyrosine/serine/threonine phosphatase activity;GO:0008330|protein tyrosine/threonine phosphatase activity;GO:0008579|JUN kinase phosphatase activity;GO:0030295|protein kinase activator activity;GO:0031434|mitogen-activated protein kinase kinase binding;GO:0031435|mitogen-activated protein kinase kinase kinase binding;","K14165","K14165; atypical dual specificity phosphatase [EC:3.1.3.16 3.1.3.48]"]
["ENSRNOG00000030930",109,9.170744282,50,3.216521909,2.851136893,1.51153731,{"v":1.62e-10,"d":"1.62E-10"},{"v":2.65e-10,"d":"2.65E-10"},"up","yes","Samsn1","protein_coding","chr11:14483893-14534900:-","gi|830260187|ref|NP_570834.2|",1485,0,"SAM domain-containing protein SAMSN-1 [Rattus norvegicus]","gi|830260186|ref|NM_130821.2|",1201,0,"Rattus norvegicus SAM domain, SH3 domain and nuclear localization signals, 1 (Samsn1), mRNA","P57725",519,{"v":5e-179,"d":"5.00E-179"},"SAM domain-containing protein SAMSN-1",".",".",".",".","pfam12485","SLY","Lymphocyte signaling adaptor protein. This domain family is found in eukaryotes, and is typically between 144 and 156 amino acids in length. The family is found in association with pfam07647, pfam07653. There is a conserved LGKK sequence motif. SLY contains a Src homology 3 domain and a sterile alpha motif, suggesting that it functions as a signaling adaptor protein in lymphocytes.","GO:0002820|negative regulation of adaptive immune response;GO:0050732|negative regulation of peptidyl-tyrosine phosphorylation;GO:0050869|negative regulation of B cell activation;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0001784|phosphotyrosine residue binding;","K23707","SAMSN1; SAM domain-containing protein SAMSN-1"]
["ENSRNOG00000000257",49,4.122628164,9,0.578973944,7.120576338,2.831994017,{"v":1.67e-10,"d":"1.67E-10"},{"v":2.73e-10,"d":"2.73E-10"},"up","yes","Smpd3","protein_coding","chr19:34162341-34245749:-","gi|564395627|ref|XP_006255605.1|",3302,0,"PREDICTED: sphingomyelin phosphodiesterase 3 isoform X1 [Rattus norvegicus]","gi|16758393|ref|NM_053605.1|",4972,0,"Rattus norvegicus sphingomyelin phosphodiesterase 3, neutral membrane (Smpd3), mRNA","O35049",1273,0,"Sphingomyelin phosphodiesterase 3",".",".",".",".","pfam03372","Exo_endo_phos","Endonuclease/Exonuclease/phosphatase family. This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins EC:4.2.99.18, DNase I proteins EC:3.1.21.1, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56, Sphingomyelinase EC:3.1.4.12 and Nocturnin.","GO:0001501|skeletal system development;GO:0001503|ossification;GO:0001932|regulation of protein phosphorylation;GO:0001958|endochondral ossification;GO:0002063|chondrocyte development;GO:0002244|hematopoietic progenitor cell differentiation;GO:0002685|regulation of leukocyte migration;GO:0003433|chondrocyte development involved in endochondral bone morphogenesis;GO:0006665|sphingolipid metabolic process;GO:0006672|ceramide metabolic process;GO:0006684|sphingomyelin metabolic process;GO:0006685|sphingomyelin catabolic process;GO:0007165|signal transduction;GO:0007568|aging;GO:0014824|artery smooth muscle contraction;GO:0015774|polysaccharide transport;GO:0030072|peptide hormone secretion;GO:0030282|bone mineralization;GO:0030324|lung development;GO:0030509|BMP signaling pathway;GO:0032963|collagen metabolic process;GO:0034614|cellular response to reactive oxygen species;GO:0035264|multicellular organism growth;GO:0043491|protein kinase B signaling;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0045840|positive regulation of mitotic nuclear division;GO:0048008|platelet-derived growth factor receptor signaling pathway;GO:0048286|lung alveolus development;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0051216|cartilage development;GO:0051481|negative regulation of cytosolic calcium ion concentration;GO:0060348|bone development;GO:0060541|respiratory system development;GO:0061035|regulation of cartilage development;GO:0070301|cellular response to hydrogen peroxide;GO:0070314|G1 to G0 transition;GO:0071286|cellular response to magnesium ion;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071461|cellular response to redox state;GO:0071897|DNA biosynthetic process;GO:0085029|extracellular matrix assembly;GO:0090494|dopamine uptake;GO:0090520|sphingolipid mediated signaling pathway;GO:0097187|dentinogenesis;GO:0098868|bone growth;GO:0140014|mitotic nuclear division;GO:0140052|cellular response to oxidised low-density lipoprotein particle stimulus;GO:1900125|regulation of hyaluronan biosynthetic process;GO:1900126|negative regulation of hyaluronan biosynthetic process;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1901653|cellular response to peptide;GO:1903543|positive regulation of exosomal secretion;GO:2000304|positive regulation of ceramide biosynthetic process;","GO:0000137|Golgi cis cisterna;GO:0000139|Golgi membrane;GO:0005576|extracellular region;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0001786|phosphatidylserine binding;GO:0004620|phospholipase activity;GO:0004767|sphingomyelin phosphodiesterase activity;GO:0005515|protein binding;GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0061751|neutral sphingomyelin phosphodiesterase activity;GO:0070300|phosphatidic acid binding;","K12352","SMPD3; sphingomyelin phosphodiesterase 3 [EC:3.1.4.12]"]
["ENSRNOG00000004882",128,10.76931439,66,4.24580892,2.53645762,1.342815055,2.32E-10,{"v":3.77e-10,"d":"3.77E-10"},"up","yes","Capn6","protein_coding","chrX:107380774-107405489:-","gi|149030117|gb|EDL85194.1|",3463,0,"rCG23172, isoform CRA_a [Rattus norvegicus]","gi|13929145|ref|NM_031808.1|",3464,0,"Rattus norvegicus calpain 6 (Capn6), mRNA","O88501",1336,0,"Calpain-6",".",".",".",".","pfam00648","Peptidase_C2","Calpain family cysteine protease.","GO:0001578|microtubule bundle formation;GO:0006508|proteolysis;GO:0051493|regulation of cytoskeleton organization;","GO:0005737|cytoplasm;GO:0005874|microtubule;GO:0005876|spindle microtubule;GO:0048471|perinuclear region of cytoplasm;","GO:0004198|calcium-dependent cysteine-type endopeptidase activity;GO:0008017|microtubule binding;","K08575","CAPN6; calpain-6 [EC:3.4.22.-]"]
["ENSRNOG00000015945",62,5.216386656,17,1.093617449,4.769845854,2.253942644,{"v":2.57e-10,"d":"2.57E-10"},{"v":4.15e-10,"d":"4.15E-10"},"up","yes","Cd3g","protein_coding","chr8:45281204-45287147:-","gi|564363364|ref|XP_006242994.1|",782,{"v":9E-103,"d":"9.00E-103"},"PREDICTED: T-cell surface glycoprotein CD3 gamma chain isoform X1 [Rattus norvegicus]","gi|672061630|ref|XM_006242932.2|",492,0,"PREDICTED: Rattus norvegicus CD3 molecule, gamma (Cd3g), transcript variant X1, mRNA","Q64159",303,{"v":3E-103,"d":"3.00E-103"},"T-cell surface glycoprotein CD3 gamma chain",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.","GO:0002250|adaptive immune response;GO:0007163|establishment or maintenance of cell polarity;GO:0007166|cell surface receptor signaling pathway;GO:0008150|biological_process;GO:0015031|protein transport;GO:0045059|positive thymic T cell selection;GO:0070228|regulation of lymphocyte apoptotic process;","GO:0005575|cellular_component;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0042105|alpha-beta T cell receptor complex;","GO:0003674|molecular_function;GO:0004888|transmembrane signaling receptor activity;GO:0042802|identical protein binding;GO:0046982|protein heterodimerization activity;","K06452","CD3G; T-cell surface glycoprotein CD3 gamma chain"]
["ENSRNOG00000066649",57,4.795710313,14,0.900626135,5.32486248,2.412744267,{"v":2.73e-10,"d":"2.73E-10"},{"v":4.39e-10,"d":"4.39E-10"},"up","yes","ENSRNOG00000066649","lncRNA","chr18:21929982-21932444:-",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","pfam04293","SpoVR","SpoVR like protein. Bacillus subtilis stage V sporulation protein R is involved in spore cortex formation. Little is known about cortex biosynthesis, except that it depends on several sigma E controlled genes, including spoVR.",".",".",".",".","."]
["ENSRNOG00000015773",84,7.067362566,32,2.058574022,3.43313502,1.779526598,{"v":2.82e-10,"d":"2.82E-10"},{"v":4.53e-10,"d":"4.53E-10"},"up","yes","Il21r","protein_coding","chr1:180168097-180195522:+","gi|60223063|ref|NP_001012487.1|",2367,0,"interleukin-21 receptor precursor [Rattus norvegicus]","gi|672038437|ref|XM_006230262.2|",1741,0,"PREDICTED: Rattus norvegicus interleukin 21 receptor (Il21r), transcript variant X2, mRNA","Q9JHX3",809,0,"Interleukin-21 receptor",".",".",".",".","pfam01108","Tissue_fac","Tissue factor. This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.","GO:0008150|biological_process;GO:0019221|cytokine-mediated signaling pathway;","GO:0005575|cellular_component;GO:0016020|membrane;","GO:0003674|molecular_function;GO:0004888|transmembrane signaling receptor activity;GO:0004896|cytokine receptor activity;","K05075","IL21R, CD360; interleukin 21 receptor"]
["ENSRNOG00000003709",32,2.692328597,1,0.064330438,41.85155072,5.387209175,{"v":2.82e-10,"d":"2.82E-10"},{"v":4.53e-10,"d":"4.53E-10"},"up","yes","Kmo","protein_coding","chr13:87557286-87588881:+","gi|11024672|ref|NP_067604.1|",2525,0,"kynurenine 3-monooxygenase [Rattus norvegicus]","gi|298915137|emb|FQ210049.1|",3386,0,"Rattus norvegicus TL0ABA35YJ18 mRNA sequence","O88867",976,0,"Kynurenine 3-monooxygenase","YBL098w",274,{"v":4e-80,"d":"4.00E-80"},"COG0654","pfam01494","FAD_binding_3","FAD binding domain. This domain is involved in FAD binding in a number of enzymes.","GO:0006569|tryptophan catabolic process;GO:0007568|aging;GO:0009651|response to salt stress;GO:0014049|positive regulation of glutamate secretion;GO:0019674|NAD metabolic process;GO:0019805|quinolinate biosynthetic process;GO:0032496|response to lipopolysaccharide;GO:0034276|kynurenic acid biosynthetic process;GO:0034354|'de novo' NAD biosynthetic process from tryptophan;GO:0043420|anthranilate metabolic process;GO:0070189|kynurenine metabolic process;GO:0071222|cellular response to lipopolysaccharide;GO:0071347|cellular response to interleukin-1;GO:0097052|L-kynurenine metabolic process;GO:1901216|positive regulation of neuron death;GO:1903296|positive regulation of glutamate secretion, neurotransmission;","GO:0005615|extracellular space;GO:0005739|mitochondrion;GO:0005741|mitochondrial outer membrane;GO:0016021|integral component of membrane;","GO:0004502|kynurenine 3-monooxygenase activity;GO:0016174|NAD(P)H oxidase activity;GO:0050660|flavin adenine dinucleotide binding;GO:0071949|FAD binding;","K00486","KMO; kynurenine 3-monooxygenase [EC:1.14.13.9]"]
["ENSRNOG00000028016",144,12.11547869,80,5.146435055,2.354149728,1.235206081,{"v":2.97e-10,"d":"2.97E-10"},{"v":4.76e-10,"d":"4.76E-10"},"up","yes","Ncf2","protein_coding","chr13:64955503-64986277:+","gi|386655991|gb|AFJ19026.1|",2604,0,"neutrophil cytosolic factor 2 [Rattus norvegicus]","gi|386655992|gb|JN864042.1|",1581,0,"Rattus norvegicus strain BN neutrophil cytosolic factor 2 (Ncf2) mRNA, complete cds","O70145",946,0,"Neutrophil cytosol factor 2",".",".",".",".","pfam00018","SH3_1","SH3 domain. SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta barrel.","GO:0006909|phagocytosis;GO:0007568|aging;GO:0009410|response to xenobiotic stimulus;GO:0009749|response to glucose;GO:0014070|response to organic cyclic compound;GO:0014823|response to activity;GO:0032496|response to lipopolysaccharide;GO:0032570|response to progesterone;GO:0032870|cellular response to hormone stimulus;GO:0033993|response to lipid;GO:0034616|response to laminar fluid shear stress;GO:0042554|superoxide anion generation;GO:0043525|positive regulation of neuron apoptotic process;GO:0045730|respiratory burst;GO:0045777|positive regulation of blood pressure;GO:0050790|regulation of catalytic activity;GO:0055093|response to hyperoxia;","GO:0001669|acrosomal vesicle;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016020|membrane;GO:0043020|NADPH oxidase complex;","GO:0003674|molecular_function;GO:0008022|protein C-terminus binding;GO:0016175|superoxide-generating NADPH oxidase activity;GO:0016176|superoxide-generating NADPH oxidase activator activity;GO:0031267|small GTPase binding;","K08010","NCF2, P67PHOX; neutrophil cytosolic factor 2"]
["ENSRNOG00000003298",96,8.07698579,41,2.637547966,3.062308589,1.614619671,{"v":3.05e-10,"d":"3.05E-10"},{"v":4.88e-10,"d":"4.88E-10"},"up","yes","Cd247","protein_coding","chr13:78043307-78122263:+","gi|328802705|ref|NP_740770.2|",880,{"v":1e-112,"d":"1.00E-112"},"T-cell surface glycoprotein CD3 zeta chain isoform 1 precursor [Rattus norvegicus]","gi|328802704|ref|NM_170789.2|",1707,0,"Rattus norvegicus Cd247 molecule (Cd247), transcript variant 1, mRNA","P24161",319,{"v":1e-104,"d":"1.00E-104"},"T-cell surface glycoprotein CD3 zeta chain",".",".",".",".","pfam11628","TCR_zetazeta","T-cell surface glycoprotein CD3 zeta chain. The incorporation of the zetazeta signalling module requires one basic TCR alpha and two zetazeta aspartic acid TM residues. The structure of the zetazeta(TM) dimer consists of a left-handed coiled coil with polar contacts. Two aspartic acids are critical for zetazeta dimerization and assembly with TCR.","GO:0007166|cell surface receptor signaling pathway;GO:0050852|T cell receptor signaling pathway;GO:0065003|protein-containing complex assembly;GO:2000010|positive regulation of protein localization to cell surface;","GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0042101|T cell receptor complex;GO:0042105|alpha-beta T cell receptor complex;","GO:0003674|molecular_function;GO:0004888|transmembrane signaling receptor activity;GO:0042802|identical protein binding;GO:1990782|protein tyrosine kinase binding;","K06453","CD3Z, CD247; CD3Z antigen, zeta polypeptide"]
["ENSRNOG00000013661",191,16.06983631,122,7.848313459,2.047552815,1.033900665,{"v":3.19e-10,"d":"3.19E-10"},{"v":5.11e-10,"d":"5.11E-10"},"up","yes","Kif26a","protein_coding","chr6:131214861-131250320:+","gi|564357463|ref|XP_006240697.1|",8256,0,"PREDICTED: kinesin-like protein KIF26A isoform X1 [Rattus norvegicus]","gi|672057197|ref|XM_006240635.2|",6696,0,"PREDICTED: Rattus norvegicus kinesin family member 26A (Kif26a), transcript variant X1, mRNA","Q52KG5",2986,0,"Kinesin-like protein KIF26A","YGL216w",114,{"v":2e-24,"d":"2.00E-24"},"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0001560|regulation of cell growth by extracellular stimulus;GO:0009968|negative regulation of signal transduction;GO:0048484|enteric nervous system development;","GO:0005871|kinesin complex;GO:0005874|microtubule;","GO:0003777|microtubule motor activity;GO:0005524|ATP binding;GO:0008017|microtubule binding;","K10404","KIF26; kinesin family member 26"]
["ENSRNOG00000015994",46,3.870222358,8,0.514643505,7.52020052,2.910771131,{"v":3.46e-10,"d":"3.46E-10"},{"v":5.52e-10,"d":"5.52E-10"},"up","yes","Cd3d","protein_coding","chr8:45288749-45301809:+","gi|7709998|ref|NP_037301.1|",844,{"v":1E-108,"d":"1.00E-108"},"T-cell surface glycoprotein CD3 delta chain precursor [Rattus norvegicus]","gi|7709997|ref|NM_013169.1|",576,0,"Rattus norvegicus CD3d molecule (Cd3d), mRNA","P19377",329,{"v":4e-110,"d":"4.00E-110"},"T-cell surface glycoprotein CD3 delta chain",".",".",".",".","pfam02189","ITAM","Immunoreceptor tyrosine-based activation motif.","GO:0002250|adaptive immune response;GO:0007166|cell surface receptor signaling pathway;GO:0008150|biological_process;GO:0045059|positive thymic T cell selection;","GO:0005575|cellular_component;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0042101|T cell receptor complex;GO:0042105|alpha-beta T cell receptor complex;","GO:0003674|molecular_function;GO:0004888|transmembrane signaling receptor activity;GO:0042802|identical protein binding;","K06450","CD3D; T-cell surface glycoprotein CD3 delta chain"]
["ENSRNOG00000038916",194,16.32224212,125,8.041304773,2.02980021,1.021337732,{"v":3.5e-10,"d":"3.50E-10"},{"v":5.58e-10,"d":"5.58E-10"},"up","yes","Dram1","protein_coding","chr7:22742849-22776765:-","gi|290677861|ref|NP_001166898.1|",1255,{"v":4e-164,"d":"4.00E-164"},"DNA damage-regulated autophagy modulator protein 1 [Rattus norvegicus]","gi|290677860|ref|NM_001173427.1|",2080,0,"Rattus norvegicus DNA-damage regulated autophagy modulator 1 (Dram1), mRNA","Q9DC58",482,{"v":2e-163,"d":"2.00E-163"},"DNA damage-regulated autophagy modulator protein 1",".",".",".",".","pfam10277","Frag1","Frag1/DRAM/Sfk1 family. This family includes Frag1, DRAM and Sfk1 proteins. Frag1 (FGF receptor activating protein 1) is a protein that is conserved from fungi to humans. There are four potential iso-prenylation sites throughout the peptide, viz CILW, CIIW and CIGL. Frag1 is a membrane-spanning protein that is ubiquitously expressed in adult tissues suggesting an important cellular function. Dram is a family of proteins conserved from nematodes to humans with six hydrophobic transmembrane regions and an Endoplasmic Reticulum signal peptide. It is a lysosomal protein that induces macro-autophagy as an effector of p53-mediated death, where p53 is the tumor-suppressor gene that is frequently mutated in cancer. Expression of Dram is stress-induced. This region is also part of a family of small plasma membrane proteins, referred to as Sfk1, that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, thus allowing proper localisation of Stt4p to the actin cytoskeleton.","GO:0010506|regulation of autophagy;","GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0016021|integral component of membrane;",".","K21955","DRAM1; DNA damage-regulated autophagy modulator protein 1"]
["ENSRNOG00000022144",196,16.49051265,127,8.169965649,2.018431088,1.013234332,{"v":3.71e-10,"d":"3.71E-10"},{"v":5.9e-10,"d":"5.90E-10"},"up","yes","AABR07072356.1","protein_coding","chr13:100656593-100657445:+","gi|206597450|ref|NP_001128641.1|",431,{"v":9e-50,"d":"9.00E-50"},"transmembrane protein 14C [Rattus norvegicus]","gi|298910719|emb|FQ225707.1|",813,0,"Rattus norvegicus TL0AEA4YC01 mRNA sequence","Q9CQN6",167,{"v":3e-50,"d":"3.00E-50"},"Transmembrane protein 14C",".",".",".",".","pfam03647","Tmemb_14","Transmembrane proteins 14C. This family of short membrane proteins are as yet uncharacterized.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000033791",113,9.507285357,55,3.5381741,2.687059791,1.426028424,{"v":4.55e-10,"d":"4.55E-10"},{"v":7.21e-10,"d":"7.21E-10"},"up","yes","Apc2","protein_coding","chr7:9392336-9414310:-","gi|564358051|ref|XP_006240940.1|",9753,0,"PREDICTED: adenomatous polyposis coli protein 2 isoform X3 [Rattus norvegicus]","gi|672057726|ref|XM_006240880.2|",9611,0,"PREDICTED: Rattus norvegicus adenomatosis polyposis coli 2 (Apc2), transcript variant X5, mRNA","Q9Z1K7",3499,0,"Adenomatous polyposis coli protein 2",".",".",".",".","pfam05956","APC_basic","APC basic domain. This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.","GO:0000226|microtubule cytoskeleton organization;GO:0001708|cell fate specification;GO:0007026|negative regulation of microtubule depolymerization;GO:0007389|pattern specification process;GO:0007399|nervous system development;GO:0008150|biological_process;GO:0016055|Wnt signaling pathway;GO:0016477|cell migration;GO:0045595|regulation of cell differentiation;GO:0045732|positive regulation of protein catabolic process;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0090630|activation of GTPase activity;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005881|cytoplasmic microtubule;GO:0005884|actin filament;GO:0015630|microtubule cytoskeleton;GO:0016342|catenin complex;GO:0030496|midbody;GO:0030877|beta-catenin destruction complex;GO:0031258|lamellipodium membrane;GO:0045171|intercellular bridge;GO:0048471|perinuclear region of cytoplasm;GO:0098794|postsynapse;","GO:0003674|molecular_function;GO:0008013|beta-catenin binding;GO:0008017|microtubule binding;GO:0045295|gamma-catenin binding;","K02085","APC; adenomatosis polyposis coli protein"]
["ENSRNOG00000005287",162,13.62991352,97,6.240052504,2.184262634,1.127146335,{"v":5.19e-10,"d":"5.19E-10"},{"v":8.18e-10,"d":"8.18E-10"},"up","yes","Syne3","protein_coding","chr6:123873174-123953409:-","gi|157823001|ref|NP_001100232.1|",4521,0,"nesprin-3 [Rattus norvegicus]","gi|157823000|ref|NM_001106762.1|",5062,0,"Rattus norvegicus spectrin repeat containing, nuclear envelope family member 3 (Syne3), mRNA","Q4FZC9",1609,0,"Nesprin-3",".",".",".",".","pfam10541","KASH","Nuclear envelope localisation domain. The KASH (for Klarsicht/ANC-1/Syne-1 homology) or KLS domain is a highly hydrophobic nuclear envelope localisation domain of approximately 60 amino acids comprising a 20-amino-acid transmembrane region and a 30-35-residue C-terminal region that lies between the inner and the outer nuclear membranes. During meiotic prophase, telomeres cluster to form a bouquet arrangement of chromosomes. SUN and KASH domain proteins form complexes that span both membranes of the nuclear envelope. The KASH domain links the dynein motor complex of the microtubules, through the outer nuclear membrane to the Sad1 domain in the inner nuclear membrane which then interacts with the bouquet proteins Bqt1 and Bqt2 that are complexed with Bqt4, Rap1 and Taz1 and attached to the telomere. SUN domain-containing proteins are essential for recruiting KASH domain proteins at the outer nuclear membrane, and KASH domains provide a generic NE tethering device for functionally distinct proteins whose cytoplasmic domains mediate nuclear positioning, maintain physical connections with other cellular organelles, and possibly even influence chromosome dynamics.","GO:0007010|cytoskeleton organization;GO:0007097|nuclear migration;GO:0008360|regulation of cell shape;GO:0090150|establishment of protein localization to membrane;","GO:0005635|nuclear envelope;GO:0005640|nuclear outer membrane;GO:0005737|cytoplasm;GO:0016021|integral component of membrane;GO:0031965|nuclear membrane;GO:0034993|meiotic nuclear membrane microtubule tethering complex;","GO:0051015|actin filament binding;","K21761","SYNE3; nesprin-3"]
["ENSRNOG00000062297",62,5.216386656,18,1.157947887,4.504854418,2.171480484,{"v":6.44e-10,"d":"6.44E-10"},{"v":1.01E-9,"d":"1.01E-09"},"up","yes","Klra5","protein_coding","chr4:164806003-164823382:-","gi|672051289|ref|XP_008761566.1|",1346,0,"PREDICTED: killer cell lectin-like receptor, subfamily A, member 5 isoform X3 [Rattus norvegicus]","gi|38454231|ref|NM_198746.1|",1128,0,"Rattus norvegicus killer cell lectin-like receptor, subfamily A, member 5 (Klra5), mRNA","Q60652",322,{"v":6e-107,"d":"6.00E-107"},"Killer cell lectin-like receptor 5",".",".",".",".","pfam08391","Ly49","Ly49-like protein, N-terminal region. The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).","GO:0030101|natural killer cell activation;","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000016278",37,3.11300494,4,0.257321753,12.09771388,3.59666254,{"v":6.56e-10,"d":"6.56E-10"},{"v":1.03E-9,"d":"1.03E-09"},"up","yes","Ccl17","protein_coding","chr19:10202128-10203819:-","gi|149032433|gb|EDL87324.1|",432,{"v":1E-51,"d":"1.00E-51"},"chemokine (C-C motif) ligand 17 [Rattus norvegicus]","gi|755526535|ref|XM_011248331.1|",285,{"v":5e-146,"d":"5.00E-146"},"PREDICTED: Mus musculus chemokine (C-C motif) ligand 17 (Ccl17), transcript variant X3, mRNA","Q95N01",111,{"v":7e-30,"d":"7.00E-30"},"C-C motif chemokine 17",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0002548|monocyte chemotaxis;GO:0006954|inflammatory response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0008150|biological_process;GO:0030593|neutrophil chemotaxis;GO:0031640|killing of cells of other organism;GO:0043547|positive regulation of GTPase activity;GO:0045662|negative regulation of myoblast differentiation;GO:0048247|lymphocyte chemotaxis;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098|chemokine-mediated signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;","GO:0005575|cellular_component;GO:0005615|extracellular space;","GO:0008009|chemokine activity;GO:0031729|CCR4 chemokine receptor binding;GO:0048020|CCR chemokine receptor binding;","K21083","CCL17; C-C motif chemokine 17"]
["ENSRNOG00000028077",37,3.11300494,4,0.257321753,12.09771388,3.59666254,{"v":6.56e-10,"d":"6.56E-10"},{"v":1.03E-9,"d":"1.03E-09"},"up","yes","Cfap44","protein_coding","chr11:56201049-56283986:-","gi|672071361|ref|XP_008767007.1|",8288,0,"PREDICTED: WD repeat-containing protein 52 isoform X2 [Rattus norvegicus]","gi|672071360|ref|XM_008768785.1|",5863,0,"PREDICTED: Rattus norvegicus cilia and flagella associated protein 44 (Cfap44), transcript variant X2, mRNA","Q96MT7",1310,0,"Cilia- and flagella-associated protein 44",".",".",".",".","pfam10174","Cast","RIM-binding protein of the cytomatrix active zone. This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.","GO:0000226|microtubule cytoskeleton organization;GO:0006508|proteolysis;GO:0007288|sperm axoneme assembly;GO:0030317|flagellated sperm motility;GO:0060271|cilium assembly;GO:0060285|cilium-dependent cell motility;",".","GO:0008233|peptidase activity;","K24224","CFAP44, WDR52; cilia- and flagella-associated protein 44"]
["ENSRNOG00000004067",45,3.786087089,8,0.514643505,7.3567179,2.879062271,{"v":6.65e-10,"d":"6.65E-10"},{"v":1.04e-09,"d":"1.04E-09"},"up","yes","Nrcam","protein_coding","chr6:61329863-61702992:+","gi|47058952|ref|NP_037282.1|",6747,0,"neuronal cell adhesion molecule precursor [Rattus norvegicus]","gi|47058951|ref|NM_013150.1|",7502,0,"Rattus norvegicus neuronal cell adhesion molecule (Nrcam), mRNA","Q810U4",2447,0,"Neuronal cell adhesion molecule",".",".",".",".","pfam13882","Bravo_FIGEY","Bravo-like intracellular region. This is the very C-terminal intracellular region of neural adhesion molecule L1 proteins that are also known as Bravo or NrCAM. It lies upstream of the IG and Fn3 domains and has the highly conserved motif FIGEY. The function is not known.","GO:0001525|angiogenesis;GO:0007155|cell adhesion;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007411|axon guidance;GO:0007417|central nervous system development;GO:0008104|protein localization;GO:0010975|regulation of neuron projection development;GO:0019227|neuronal action potential propagation;GO:0031290|retinal ganglion cell axon guidance;GO:0034113|heterotypic cell-cell adhesion;GO:0045162|clustering of voltage-gated sodium channels;GO:0070593|dendrite self-avoidance;GO:0098609|cell-cell adhesion;GO:0099175|regulation of postsynapse organization;","GO:0005576|extracellular region;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0033268|node of Ranvier;GO:0043194|axon initial segment;GO:0045202|synapse;GO:0098978|glutamatergic synapse;GO:0099055|integral component of postsynaptic membrane;GO:0099061|integral component of postsynaptic density membrane;","GO:0030506|ankyrin binding;GO:0086080|protein binding involved in heterotypic cell-cell adhesion;GO:0098632|cell-cell adhesion mediator activity;","K06756","NRCAM; neuronal cell adhesion molecule"]
["ENSRNOG00000027833",124,10.43277331,65,4.181478482,2.494996293,1.319037672,{"v":7.59e-10,"d":"7.59E-10"},{"v":1.18e-09,"d":"1.18E-09"},"up","yes","Fnip2","protein_coding","chr2:164598906-164707901:-","gi|672042703|ref|XP_008759321.1|",5754,0,"PREDICTED: folliculin-interacting protein 2 isoform X1 [Rattus norvegicus]","gi|672042702|ref|XM_008761099.1|",5543,0,"PREDICTED: Rattus norvegicus folliculin interacting protein 2 (Fnip2), transcript variant X1, mRNA","Q80TD3",1870,0,"Folliculin-interacting protein 2",".",".",".",".","pfam14637","FNIP_M","Folliculin-interacting protein middle domain. This is the middle domain of folliculin-interacting proteins.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001932|regulation of protein phosphorylation;GO:0006468|protein phosphorylation;GO:0008285|negative regulation of cell proliferation;GO:0008630|intrinsic apoptotic signaling pathway in response to DNA damage;GO:0031334|positive regulation of protein complex assembly;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0043086|negative regulation of catalytic activity;","GO:0005737|cytoplasm;GO:0005765|lysosomal membrane;GO:0005829|cytosol;GO:0034451|centriolar satellite;","GO:0042030|ATPase inhibitor activity;GO:0051087|chaperone binding;","K20401","FNIP2; folliculin-interacting protein 2"]
["ENSRNOG00000000486",174,14.63953674,109,7.012017762,2.087778046,1.061968346,{"v":8.48e-10,"d":"8.48E-10"},{"v":1.32E-9,"d":"1.32E-09"},"up","yes","Ggnbp1","protein_coding","chr20:5099311-5116183:+","gi|58000421|ref|NP_001009972.1|",1787,0,"gametogenetin-binding protein 1 [Rattus norvegicus]","gi|76779337|gb|BC105838.1|",1394,0,"Rattus norvegicus gametogenetin-binding protein 1, mRNA (cDNA clone MGC:124911 IMAGE:7452960), complete cds","Q5J2D6",691,0,"Gametogenetin-binding protein 1",".",".",".",".","pfam14836","Ubiquitin_3","Ubiquitin-like domain. This ubiquitin-like domain is found in several ubiquitin carboxyl-terminal hydrolases and in gametogenetin-binding protein.","GO:0000266|mitochondrial fission;GO:0007283|spermatogenesis;GO:0030154|cell differentiation;","GO:0005737|cytoplasm;GO:0005758|mitochondrial intermembrane space;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;",".",".","."]
["ENSRNOG00000024620",55,4.627439776,14,0.900626135,5.1380252,2.361213966,{"v":9.14e-10,"d":"9.14E-10"},{"v":1.42e-09,"d":"1.42E-09"},"up","yes","Mamdc2","protein_coding","chr1:220863976-221016354:-","gi|564298967|ref|XP_006223741.1|",3605,0,"PREDICTED: MAM domain-containing protein 2 isoform X1 [Rattus norvegicus]","gi|672014738|ref|XM_006223679.2|",3372,0,"PREDICTED: Rattus norvegicus MAM domain containing 2 (Mamdc2), transcript variant X1, mRNA","Q8CG85",1330,0,"MAM domain-containing protein 2",".",".",".",".","pfam00629","MAM","MAM domain. An extracellular domain found in many receptors.",".",".",".",".","."]
["ENSRNOG00000010685",30,2.524058059,0,0.032165219,78.4716576,6.29409977,{"v":1.07E-9,"d":"1.07E-09"},{"v":1.65e-09,"d":"1.65E-09"},"up","yes","Tbx18","protein_coding","chr8:88652054-88680058:-","gi|157823511|ref|NP_001101643.1|",2679,0,"T-box transcription factor TBX18 [Rattus norvegicus]","gi|157823510|ref|NM_001108173.1|",4611,0,"Rattus norvegicus T-box18 (Tbx18), mRNA","Q9EPZ6",993,0,"T-box transcription factor TBX18",".",".",".",".","pfam00907","T-box","T-box. The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001708|cell fate specification;GO:0001756|somitogenesis;GO:0002053|positive regulation of mesenchymal cell proliferation;GO:0003163|sinoatrial node development;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007605|sensory perception of sound;GO:0008150|biological_process;GO:0009948|anterior/posterior axis specification;GO:0016331|morphogenesis of embryonic epithelium;GO:0022409|positive regulation of cell-cell adhesion;GO:0030154|cell differentiation;GO:0048646|anatomical structure formation involved in morphogenesis;GO:0050679|positive regulation of epithelial cell proliferation;GO:0051145|smooth muscle cell differentiation;GO:0060829|negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation;GO:0060930|sinoatrial node cell fate commitment;GO:0060931|sinoatrial node cell development;GO:0072189|ureter development;GO:0090103|cochlea morphogenesis;GO:0098907|regulation of SA node cell action potential;GO:2000729|positive regulation of mesenchymal cell proliferation involved in ureter development;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0090571|RNA polymerase II transcription repressor complex;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0042803|protein homodimerization activity;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;GO:1990837|sequence-specific double-stranded DNA binding;","K10183","TBX18; T-box protein 18"]
["ENSRNOG00000021510",80,6.730821492,31,1.994243584,3.375125058,1.754940959,{"v":1.08E-9,"d":"1.08E-09"},{"v":1.66e-09,"d":"1.66E-09"},"up","yes","Tbc1d10c","protein_coding","chr1:201477157-201564920:-","gi|126517485|ref|NP_001075449.1|",2069,0,"carabin [Rattus norvegicus]","gi|126517484|ref|NM_001081980.1|",1707,0,"Rattus norvegicus TBC1 domain family, member 10C (Tbc1d10c), mRNA","Q8C9V1",743,0,"Carabin","YGR100w",125,{"v":3e-29,"d":"3.00E-29"},"COG5210","pfam00566","RabGAP-TBC","Rab-GTPase-TBC domain. Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.","GO:0006886|intracellular protein transport;GO:0042147|retrograde transport, endosome to Golgi;GO:0050869|negative regulation of B cell activation;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0070885|negative regulation of calcineurin-NFAT signaling cascade;GO:0090630|activation of GTPase activity;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0031527|filopodium membrane;","GO:0005096|GTPase activator activity;","K19944","TBC1D10; TBC1 domain family member 10"]
["ENSRNOG00000000907",106,8.918338477,51,3.280852347,2.71829925,1.442704287,{"v":1.13E-9,"d":"1.13E-09"},{"v":1.73E-9,"d":"1.73E-09"},"up","yes","Alox5ap","protein_coding","chr12:5748944-5772986:-","gi|8392897|ref|NP_058956.1|",767,{"v":3e-99,"d":"3.00E-99"},"arachidonate 5-lipoxygenase-activating protein [Rattus norvegicus]","gi|55926225|ref|NM_017260.2|",934,0,"Rattus norvegicus arachidonate 5-lipoxygenase activating protein (Alox5ap), mRNA","P20291",300,{"v":1E-100,"d":"1.00E-100"},"Arachidonate 5-lipoxygenase-activating protein",".",".",".",".","pfam01124","MAPEG","MAPEG family. This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolizm). It includes proteins such as Prostaglandin E synthase. This enzyme catalyses the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.","GO:0002540|leukotriene production involved in inflammatory response;GO:0002675|positive regulation of acute inflammatory response;GO:0019370|leukotriene biosynthetic process;GO:0019372|lipoxygenase pathway;GO:0050790|regulation of catalytic activity;GO:0070207|protein homotrimerization;GO:0071277|cellular response to calcium ion;GO:0098869|cellular oxidant detoxification;","GO:0005634|nucleus;GO:0005635|nuclear envelope;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005829|cytosol;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0031965|nuclear membrane;","GO:0004051|arachidonate 5-lipoxygenase activity;GO:0004364|glutathione transferase activity;GO:0004464|leukotriene-C4 synthase activity;GO:0004602|glutathione peroxidase activity;GO:0008047|enzyme activator activity;GO:0019899|enzyme binding;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;GO:0047485|protein N-terminus binding;GO:0050544|arachidonic acid binding;","K20735","ALOX5AP, FLAP; arachidonate 5-lipoxygenase-activating protein"]
["ENSRNOG00000024569",136,11.44239654,76,4.889113302,2.340382771,1.226744503,{"v":1.13E-9,"d":"1.13E-09"},{"v":1.74E-9,"d":"1.74E-09"},"up","yes","Gimap9","protein_coding","chr4:77626138-77629497:+","gi|56676322|ref|NP_001008399.1|",1444,0,"GTPase, IMAP family member 9 [Rattus norvegicus]","gi|73909202|gb|BC103635.1|",1700,0,"Rattus norvegicus GTPase, IMAP family member 9, mRNA (cDNA clone MGC:124918 IMAGE:7100941), complete cds","Q8NHV1",306,{"v":6e-96,"d":"6.00E-96"},"GTPase IMAP family member 7",".",".",".",".","pfam04548","AIG1","AIG1 family. Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.",".","GO:0005829|cytosol;","GO:0005525|GTP binding;",".","."]
["ENSRNOG00000009862",46,3.870222358,9,0.578973944,6.684622685,2.740846129,{"v":1.15E-9,"d":"1.15E-09"},{"v":1.77e-09,"d":"1.77E-09"},"up","yes","Olfm1","protein_coding","chr3:11520729-11558239:+","gi|17865343|ref|NP_446025.1|",2639,0,"noelin precursor [Rattus norvegicus]","gi|17865342|ref|NM_053573.1|",2753,0,"Rattus norvegicus olfactomedin 1 (Olfm1), mRNA","Q62609",1021,0,"Noelin",".",".",".",".","pfam02191","OLF","Olfactomedin-like domain.","GO:0003190|atrioventricular valve formation;GO:0007399|nervous system development;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010718|positive regulation of epithelial to mesenchymal transition;GO:0023041|neuronal signal transduction;GO:0030516|regulation of axon extension;GO:0043065|positive regulation of apoptotic process;GO:0060317|cardiac epithelial to mesenchymal transition;GO:1902003|regulation of amyloid-beta formation;GO:1902430|negative regulation of amyloid-beta formation;GO:2001223|negative regulation of neuron migration;","GO:0005615|extracellular space;GO:0005783|endoplasmic reticulum;GO:0030424|axon;GO:0032281|AMPA glutamate receptor complex;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0044295|axonal growth cone;GO:0097060|synaptic membrane;GO:0098978|glutamatergic synapse;GO:0099243|extrinsic component of synaptic membrane;","GO:0001540|amyloid-beta binding;GO:0042802|identical protein binding;","K25444","OLFM1; noelin"]
["ENSRNOG00000022012",46,3.870222358,9,0.578973944,6.684622685,2.740846129,{"v":1.15E-9,"d":"1.15E-09"},{"v":1.77e-09,"d":"1.77E-09"},"up","yes","Tnfrsf18","protein_coding","chr5:166618969-166622353:+","gi|149024859|gb|EDL81356.1|",1459,0,"similar to tumor necrosis factor receptor superfamily, member 18, isoform CRA_b [Rattus norvegicus]","gi|672055010|ref|XM_008764373.1|",1405,0,"PREDICTED: Rattus norvegicus tumor necrosis factor receptor superfamily, member 18 (Tnfrsf18), transcript variant X1, mRNA","O35714",390,{"v":6e-131,"d":"6.00E-131"},"Tumor necrosis factor receptor superfamily member 18",".",".",".",".","pfam07562","NCD3G","Nine Cysteines Domain of family 3 GPCR. This conserved sequence contains several highly-conserved Cys residues that are predicted to form disulphide bridges. It is predicted to lie outside the cell membrane, tethered to the pfam00003 in several receptor proteins.","GO:0002687|positive regulation of leukocyte migration;GO:0033209|tumor necrosis factor-mediated signaling pathway;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0043066|negative regulation of apoptotic process;GO:0045785|positive regulation of cell adhesion;","GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;","GO:0005031|tumor necrosis factor-activated receptor activity;","K05154","TNFRSF18, GITR, CD357; tumor necrosis factor receptor superfamily member 18"]
["ENSRNOG00000043414",34,2.860599134,3,0.192991315,14.82242421,3.889709515,{"v":1.16e-09,"d":"1.16E-09"},{"v":1.78e-09,"d":"1.78E-09"},"up","yes","Fcrl5","protein_coding","chr2:172881448-172913148:+","gi|672015986|ref|XP_008773409.1|",2880,0,"PREDICTED: Fc receptor-like protein 4 isoform X1 [Rattus norvegicus]","gi|672015985|ref|XM_008775187.1|",1806,0,"PREDICTED: Rattus norvegicus Fc receptor-like 3 (Fcrl3), transcript variant X1, mRNA","Q68SN8",912,0,"Fc receptor-like protein 5",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0050859|negative regulation of B cell receptor signaling pathway;GO:0051280|negative regulation of release of sequestered calcium ion into cytosol;","GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0043235|receptor complex;",".","K06727","FCRL, IRTA, CD307; Fc receptor-like protein"]
["ENSRNOG00000006167",93,7.824579984,41,2.637547966,2.966611446,1.568815981,{"v":1.28e-09,"d":"1.28E-09"},{"v":1.96e-09,"d":"1.96E-09"},"up","yes","Rasal3","protein_coding","chr7:11396090-11411465:-","gi|564358455|ref|XP_006241121.1|",4827,0,"PREDICTED: RAS protein activator like-3 isoform X1 [Rattus norvegicus]","gi|197381463|ref|NM_001134562.1|",3922,0,"Rattus norvegicus RAS protein activator like 3 (Rasal3), mRNA","Q8C2K5",1673,0,"RAS protein activator like-3",".",".",".",".","pfam00616","RasGAP","GTPase-activator protein for Ras-like GTPase. All alpha-helical domain that accelerates the GTPase activity of Ras, thereby \"switching\" it into an \"off\" position.","GO:0007165|signal transduction;GO:0043087|regulation of GTPase activity;GO:0046580|negative regulation of Ras protein signal transduction;GO:0051142|positive regulation of NK T cell proliferation;","GO:0005737|cytoplasm;GO:0098562|cytoplasmic side of membrane;","GO:0042802|identical protein binding;","K17634","RASAL3; RAS protein activator-like 3"]
["ENSRNOG00000064438",113,9.507285357,57,3.666834977,2.592776991,1.374498123,{"v":1.34e-09,"d":"1.34E-09"},{"v":2.05e-09,"d":"2.05E-09"},"up","yes","ENSRNOG00000064438","lncRNA","chr7:17011814-17030581:-","gi|672058315|ref|XP_008763488.1|",287,{"v":7e-26,"d":"7.00E-26"},"PREDICTED: inactive phospholipase C-like protein 2 [Rattus norvegicus]","gi|672058395|ref|XR_593342.1|",1702,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102556259 (LOC102556259), transcript variant X6, misc_RNA","Q8K394",69.3,{"v":2E-16,"d":"2.00E-16"},"Inactive phospholipase C-like protein 2",".",".",".",".","pfam04173","DoxD","TQO small subunit DoxD. DoxD is a subunit of the terminal quinol oxidase present in the plasma membrane of Acidianus ambivalens, with calculated molecular mass of 20.4 kDa. Thiosulphate:quinone oxidoreductase (TQO) is one of the early steps in elemental sulphur oxidation. A novel TQO enzyme was purified from the thermo-acidophilic archaeon Acidianus ambivalens and shown to consist of a large subunit (DoxD) and a smaller subunit (DoxA). The DoxD- and DoxA-like two subunits are fused together in a single polypeptide in Bacteroides thetaiotaomicron DoxD.",".",".",".",".","."]
["ENSRNOG00000019057",42,3.533681283,7,0.450313067,7.84716576,2.972171675,{"v":1.37E-9,"d":"1.37E-09"},{"v":2.09E-9,"d":"2.09E-09"},"up","yes","Prkcq","protein_coding","chr17:67246394-67378704:-","gi|454515948|ref|NP_001263650.1|",3775,0,"protein kinase C theta type [Rattus norvegicus]","gi|454515947|ref|NM_001276721.1|",3370,0,"Rattus norvegicus protein kinase C, theta (Prkcq), mRNA","Q9WTQ0",1454,0,"Protein kinase C theta type",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0001666|response to hypoxia;GO:0002376|immune system process;GO:0006355|regulation of transcription, DNA-templated;GO:0006468|protein phosphorylation;GO:0006509|membrane protein ectodomain proteolysis;GO:0006954|inflammatory response;GO:0007568|aging;GO:0009408|response to heat;GO:0009749|response to glucose;GO:0010389|regulation of G2/M transition of mitotic cell cycle;GO:0014070|response to organic cyclic compound;GO:0018105|peptidyl-serine phosphorylation;GO:0019229|regulation of vasoconstriction;GO:0030182|neuron differentiation;GO:0032212|positive regulation of telomere maintenance via telomerase;GO:0032740|positive regulation of interleukin-17 production;GO:0032743|positive regulation of interleukin-2 production;GO:0032753|positive regulation of interleukin-4 production;GO:0032868|response to insulin;GO:0035556|intracellular signal transduction;GO:0042102|positive regulation of T cell proliferation;GO:0042246|tissue regeneration;GO:0042307|positive regulation of protein import into nucleus;GO:0045730|respiratory burst;GO:0046627|negative regulation of insulin receptor signaling pathway;GO:0050714|positive regulation of protein secretion;GO:0050870|positive regulation of T cell activation;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051491|positive regulation of filopodium assembly;GO:0051496|positive regulation of stress fiber assembly;GO:0051973|positive regulation of telomerase activity;GO:0060326|cell chemotaxis;GO:0070233|negative regulation of T cell apoptotic process;GO:0090330|regulation of platelet aggregation;GO:1904355|positive regulation of telomere capping;GO:2000318|positive regulation of T-helper 17 type immune response;GO:2000570|positive regulation of T-helper 2 cell activation;","GO:0001772|immunological synapse;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016235|aggresome;GO:0031594|neuromuscular junction;GO:0034451|centriolar satellite;GO:0042383|sarcolemma;","GO:0004674|protein serine/threonine kinase activity;GO:0004697|protein kinase C activity;GO:0004698|calcium-dependent protein kinase C activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0046872|metal ion binding;","K18052","PRKCQ; novel protein kinase C theta type [EC:2.7.11.13]"]
["ENSRNOG00000009465",38,3.197140209,5,0.321652191,9.939743297,3.313208593,{"v":1.39E-9,"d":"1.39E-09"},{"v":2.13e-09,"d":"2.13E-09"},"up","yes","Sfrp2","protein_coding","chr2:169089517-169097063:+","gi|635045300|ref|XP_007998238.1|",1569,0,"PREDICTED: secreted frizzled-related protein 2 [Chlorocebus sabaeus]","gi|189181699|ref|NM_001100700.1|",1976,0,"Rattus norvegicus secreted frizzled-related protein 2 (Sfrp2), mRNA","P97299",570,0,"Secreted frizzled-related protein 2",".",".",".",".","pfam01392","Fz","Fz domain. Also known as the CRD (cysteine rich domain), the C6 box in MuSK receptor. This domain of unknown function has been independently identified by several groups. The domain contains 10 conserved cysteines.","GO:0001569|branching involved in blood vessel morphogenesis;GO:0001756|somitogenesis;GO:0001843|neural tube closure;GO:0002063|chondrocyte development;GO:0003151|outflow tract morphogenesis;GO:0003214|cardiac left ventricle morphogenesis;GO:0006915|apoptotic process;GO:0007267|cell-cell signaling;GO:0007584|response to nutrient;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0008584|male gonad development;GO:0009410|response to xenobiotic stimulus;GO:0009952|anterior/posterior pattern specification;GO:0010629|negative regulation of gene expression;GO:0010667|negative regulation of cardiac muscle cell apoptotic process;GO:0010719|negative regulation of epithelial to mesenchymal transition;GO:0010950|positive regulation of endopeptidase activity;GO:0010975|regulation of neuron projection development;GO:0021915|neural tube development;GO:0030111|regulation of Wnt signaling pathway;GO:0030178|negative regulation of Wnt signaling pathway;GO:0030199|collagen fibril organization;GO:0030307|positive regulation of cell growth;GO:0030308|negative regulation of cell growth;GO:0030336|negative regulation of cell migration;GO:0030514|negative regulation of BMP signaling pathway;GO:0031668|cellular response to extracellular stimulus;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0033630|positive regulation of cell adhesion mediated by integrin;GO:0035567|non-canonical Wnt signaling pathway;GO:0036342|post-anal tail morphogenesis;GO:0042127|regulation of cell proliferation;GO:0042662|negative regulation of mesodermal cell fate specification;GO:0042733|embryonic digit morphogenesis;GO:0042981|regulation of apoptotic process;GO:0043065|positive regulation of apoptotic process;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043508|negative regulation of JUN kinase activity;GO:0045600|positive regulation of fat cell differentiation;GO:0045669|positive regulation of osteoblast differentiation;GO:0045766|positive regulation of angiogenesis;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046546|development of primary male sexual characteristics;GO:0048546|digestive tract morphogenesis;GO:0050680|negative regulation of epithelial cell proliferation;GO:0050732|negative regulation of peptidyl-tyrosine phosphorylation;GO:0051216|cartilage development;GO:0060028|convergent extension involved in axis elongation;GO:0060070|canonical Wnt signaling pathway;GO:0060349|bone morphogenesis;GO:0061056|sclerotome development;GO:0061185|negative regulation of dermatome development;GO:0071425|hematopoietic stem cell proliferation;GO:0071481|cellular response to X-ray;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0090175|regulation of establishment of planar polarity;GO:0090179|planar cell polarity pathway involved in neural tube closure;GO:0090244|Wnt signaling pathway involved in somitogenesis;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:1902042|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1902230|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:1904956|regulation of midbrain dopaminergic neuron differentiation;GO:2000035|regulation of stem cell division;GO:2000041|negative regulation of planar cell polarity pathway involved in axis elongation;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0062023|collagen-containing extracellular matrix;","GO:0001968|fibronectin binding;GO:0003674|molecular_function;GO:0005178|integrin binding;GO:0008047|enzyme activator activity;GO:0017147|Wnt-protein binding;GO:0048018|receptor ligand activity;GO:0061133|endopeptidase activator activity;","K02176","SFRP2; secreted frizzled-related protein 2"]
["ENSRNOG00000070434",59,4.96398085,17,1.093617449,4.539046861,2.182389383,{"v":1.48e-09,"d":"1.48E-09"},{"v":2.25e-09,"d":"2.25E-09"},"up","yes","ENSRNOG00000070434","protein_coding","chr2:193412971-193420030:-","gi|564300827|ref|XP_006224300.1|",584,{"v":3e-70,"d":"3.00E-70"},"PREDICTED: transmembrane protein C1orf162 homolog [Rattus norvegicus]","gi|672016201|ref|XM_006224238.2|",1031,0,"PREDICTED: Rattus norvegicus hypothetical LOC100363228 (LOC100363228), mRNA","Q3U7U4",137,{"v":5e-37,"d":"5.00E-37"},"Transmembrane protein C1orf162 homolog",".",".",".",".","pfam00852","Glyco_transf_10","Glycosyltransferase family 10 (fucosyltransferase). This family of Fucosyltransferases are the enzymes transferring fucose from GDP-Fucose to GlcNAc in an alpha1,3 linkage. This family is know as glycosyltransferase family 10.",".",".",".",".","."]
["ENSRNOG00000028992",62,5.216386656,19,1.222278326,4.267756817,2.093477972,{"v":1.56E-9,"d":"1.56E-09"},{"v":2.37e-09,"d":"2.37E-09"},"up","yes","Acan","protein_coding","chr1:132981582-133043627:+","gi|149057245|gb|EDM08568.1|",9991,0,"aggrecan 1, isoform CRA_a [Rattus norvegicus]","gi|11990615|ref|NM_022190.1|",6906,0,"Rattus norvegicus aggrecan (Acan), mRNA","P07897",3735,0,"Aggrecan core protein",".",".",".",".","pfam00193","Xlink","Extracellular link domain.","GO:0001501|skeletal system development;GO:0001502|cartilage condensation;GO:0001503|ossification;GO:0002063|chondrocyte development;GO:0007155|cell adhesion;GO:0007417|central nervous system development;GO:0007507|heart development;GO:0009314|response to radiation;GO:0009410|response to xenobiotic stimulus;GO:0009612|response to mechanical stimulus;GO:0009629|response to gravity;GO:0009749|response to glucose;GO:0010259|multicellular organism aging;GO:0010447|response to acidic pH;GO:0014070|response to organic cyclic compound;GO:0021510|spinal cord development;GO:0030166|proteoglycan biosynthetic process;GO:0030199|collagen fibril organization;GO:0030336|negative regulation of cell migration;GO:0060591|chondroblast differentiation;GO:0071363|cellular response to growth factor stimulus;","GO:0005576|extracellular region;GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0031012|extracellular matrix;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0072534|perineuronal net;GO:0098966|perisynaptic extracellular matrix;GO:0098978|glutamatergic synapse;GO:0098982|GABA-ergic synapse;","GO:0005509|calcium ion binding;GO:0005540|hyaluronic acid binding;GO:0030246|carbohydrate binding;","K06792","AGC1, CSPG1; aggrecan 1"]
["ENSRNOG00000047782",62,5.216386656,19,1.222278326,4.267756817,2.093477972,{"v":1.56E-9,"d":"1.56E-09"},{"v":2.37e-09,"d":"2.37E-09"},"up","yes","RGD1309808","protein_coding","chr7:109305709-109322865:+","gi|564360837|ref|XP_006241996.1|",1488,0,"PREDICTED: apolipoprotein L3 isoform X2 [Rattus norvegicus]","gi|672059714|ref|XM_006241935.2|",2258,0,"PREDICTED: Rattus norvegicus similar to apolipoprotein L2; apolipoprotein L-II (RGD1309808), transcript variant X2, mRNA","O95236",161,{"v":9e-42,"d":"9.00E-42"},"Apolipoprotein L3",".",".",".",".","pfam05461","ApoL","Apolipoprotein L. Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.","GO:0006869|lipid transport;GO:0042157|lipoprotein metabolic process;","GO:0005576|extracellular region;",".","K14480","APOL; apolipoprotein L"]
["ENSRNOG00000010716",127,10.68517912,69,4.438800235,2.407222347,1.267369405,{"v":1.57E-9,"d":"1.57E-09"},{"v":2.38e-09,"d":"2.38E-09"},"up","yes","Atoh8","protein_coding","chr4:104259992-104292168:-","gi|157823435|ref|NP_001102711.1|",1253,{"v":2e-163,"d":"2.00E-163"},"protein atonal homolog 8 [Rattus norvegicus]","gi|157823434|ref|NM_001109241.1|",2375,0,"Rattus norvegicus atonal bHLH transcription factor 8 (Atoh8), mRNA","Q99NA2",457,{"v":2e-153,"d":"2.00E-153"},"Protein atonal homolog 8",".",".",".",".","pfam00010","HLH","Helix-loop-helix DNA-binding domain.","GO:0001704|formation of primary germ layer;GO:0001937|negative regulation of endothelial cell proliferation;GO:0006357|regulation of transcription by RNA polymerase II;GO:0010595|positive regulation of endothelial cell migration;GO:0010629|negative regulation of gene expression;GO:0030182|neuron differentiation;GO:0035148|tube formation;GO:0045603|positive regulation of endothelial cell differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0051450|myoblast proliferation;GO:0060395|SMAD protein signal transduction;GO:1902895|positive regulation of pri-miRNA transcription by RNA polymerase II;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0046983|protein dimerization activity;GO:0070888|E-box binding;","K09084","ATOH8; atonal protein 8"]
["ENSRNOG00000047493",136,11.44239654,77,4.95344374,2.309988189,1.207885475,{"v":1.79E-9,"d":"1.79E-09"},{"v":2.71e-09,"d":"2.71E-09"},"up","yes","Slco1a4","protein_coding","chr4:174710004-175254573:-","gi|13540642|ref|NP_110465.1|",3313,0,"solute carrier organic anion transporter family member 1A5 [Rattus norvegicus]","gi|672051315|ref|XM_008763351.1|",2937,0,"PREDICTED: Rattus norvegicus solute carrier organic anion transporter family, member 1A2 (Slco1a2), transcript variant X1, mRNA","O88397",1280,0,"Solute carrier organic anion transporter family member 1A5",".",".",".",".","pfam03137","OATP","Organic Anion Transporter Polypeptide (OATP) family. This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.","GO:0006820|anion transport;GO:0010468|regulation of gene expression;GO:0015721|bile acid and bile salt transport;GO:0038183|bile acid signaling pathway;GO:0043252|sodium-independent organic anion transport;GO:0055085|transmembrane transport;GO:0071466|cellular response to xenobiotic stimulus;GO:0120188|regulation of bile acid secretion;GO:1904486|response to 17alpha-ethynylestradiol;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009925|basal plasma membrane;GO:0016020|membrane;","GO:0008514|organic anion transmembrane transporter activity;GO:0015125|bile acid transmembrane transporter activity;GO:0015347|sodium-independent organic anion transmembrane transporter activity;","K03460","SLCO1A; solute carrier organic anion transporter family, member 1A"]
["ENSRNOG00000024000",87,7.319768372,37,2.380226213,3.075240636,1.620699305,{"v":1.85E-9,"d":"1.85E-09"},{"v":2.8e-09,"d":"2.80E-09"},"up","yes","Cd22","protein_coding","chr1:86117459-86132322:-","gi|157819397|ref|NP_001100973.1|",4489,0,"B-cell receptor CD22 precursor [Rattus norvegicus]","gi|157819396|ref|NM_001107503.1|",3690,0,"Rattus norvegicus CD22 molecule (Cd22), mRNA","P35329",1345,0,"B-cell receptor CD22",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0002638|negative regulation of immunoglobulin production;GO:0030100|regulation of endocytosis;GO:0030888|regulation of B cell proliferation;GO:0042113|B cell activation;GO:0050776|regulation of immune response;GO:0050849|negative regulation of calcium-mediated signaling;GO:0050859|negative regulation of B cell receptor signaling pathway;","GO:0005769|early endosome;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0032809|neuronal cell body membrane;GO:0055037|recycling endosome;","GO:0019903|protein phosphatase binding;GO:0033691|sialic acid binding;GO:0042609|CD4 receptor binding;","K06467","CD22, SIGLEC2; CD22 antigen"]
["ENSRNOG00000010522",96,8.07698579,44,2.83053928,2.853514822,1.512740057,{"v":1.92E-9,"d":"1.92E-09"},{"v":2.9e-09,"d":"2.90E-09"},"up","yes","Tlr4","protein_coding","chr5:80145826-80159628:+","gi|149059567|gb|EDM10505.1|",4145,0,"toll-like receptor 4 [Rattus norvegicus]","gi|240147721|gb|GQ175880.1|",3327,0,"Rattus norvegicus toll-like receptor 4 (Tlr4) mRNA, complete cds","Q9QX05",1595,0,"Toll-like receptor 4",".",".",".",".","pfam01582","TIR","TIR domain. The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.","GO:0001666|response to hypoxia;GO:0001774|microglial cell activation;GO:0002218|activation of innate immune response;GO:0002224|toll-like receptor signaling pathway;GO:0002246|wound healing involved in inflammatory response;GO:0002322|B cell proliferation involved in immune response;GO:0002537|nitric oxide production involved in inflammatory response;GO:0002730|regulation of dendritic cell cytokine production;GO:0002755|MyD88-dependent toll-like receptor signaling pathway;GO:0002758|innate immune response-activating signal transduction;GO:0003009|skeletal muscle contraction;GO:0006691|leukotriene metabolic process;GO:0006909|phagocytosis;GO:0006954|inflammatory response;GO:0006979|response to oxidative stress;GO:0007252|I-kappaB phosphorylation;GO:0009617|response to bacterium;GO:0009636|response to toxic substance;GO:0010572|positive regulation of platelet activation;GO:0010628|positive regulation of gene expression;GO:0014002|astrocyte development;GO:0014823|response to activity;GO:0014911|positive regulation of smooth muscle cell migration;GO:0016064|immunoglobulin mediated immune response;GO:0030890|positive regulation of B cell proliferation;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0032496|response to lipopolysaccharide;GO:0032497|detection of lipopolysaccharide;GO:0032526|response to retinoic acid;GO:0032570|response to progesterone;GO:0032680|regulation of tumor necrosis factor production;GO:0032689|negative regulation of interferon-gamma production;GO:0032700|negative regulation of interleukin-17 production;GO:0032707|negative regulation of interleukin-23 production;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032722|positive regulation of chemokine production;GO:0032727|positive regulation of interferon-alpha production;GO:0032728|positive regulation of interferon-beta production;GO:0032729|positive regulation of interferon-gamma production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032732|positive regulation of interleukin-1 production;GO:0032733|positive regulation of interleukin-10 production;GO:0032735|positive regulation of interleukin-12 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032868|response to insulin;GO:0032874|positive regulation of stress-activated MAPK cascade;GO:0034142|toll-like receptor 4 signaling pathway;GO:0035666|TRIF-dependent toll-like receptor signaling pathway;GO:0036120|cellular response to platelet-derived growth factor stimulus;GO:0042116|macrophage activation;GO:0042742|defense response to bacterium;GO:0043032|positive regulation of macrophage activation;GO:0043065|positive regulation of apoptotic process;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043278|response to morphine;GO:0043388|positive regulation of DNA binding;GO:0043406|positive regulation of MAP kinase activity;GO:0045348|positive regulation of MHC class II biosynthetic process;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0045471|response to ethanol;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046330|positive regulation of JNK cascade;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0050671|positive regulation of lymphocyte proliferation;GO:0050727|regulation of inflammatory response;GO:0050729|positive regulation of inflammatory response;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050829|defense response to Gram-negative bacterium;GO:0050965|detection of temperature stimulus involved in sensory perception of pain;GO:0050966|detection of mechanical stimulus involved in sensory perception of pain;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051384|response to glucocorticoid;GO:0051770|positive regulation of nitric-oxide synthase biosynthetic process;GO:0051930|regulation of sensory perception of pain;GO:0060729|intestinal epithelial structure maintenance;GO:0060907|positive regulation of macrophage cytokine production;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070430|positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway;GO:0070434|positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0070542|response to fatty acid;GO:0071222|cellular response to lipopolysaccharide;GO:0071223|cellular response to lipoteichoic acid;GO:0071260|cellular response to mechanical stimulus;GO:0071300|cellular response to retinoic acid;GO:0071346|cellular response to interferon-gamma;GO:0120163|negative regulation of cold-induced thermogenesis;GO:0140052|cellular response to oxidised low-density lipoprotein particle stimulus;GO:1900017|positive regulation of cytokine production involved in inflammatory response;GO:1900227|positive regulation of NLRP3 inflammasome complex assembly;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1903223|positive regulation of oxidative stress-induced neuron death;GO:1903428|positive regulation of reactive oxygen species biosynthetic process;GO:1903974|positive regulation of cellular response to macrophage colony-stimulating factor stimulus;GO:1904466|positive regulation of matrix metallopeptidase secretion;GO:1904646|cellular response to amyloid-beta;GO:1990268|response to gold nanoparticle;GO:2000343|positive regulation of chemokine (C-X-C motif) ligand 2 production;","GO:0001726|ruffle;GO:0001891|phagocytic cup;GO:0005737|cytoplasm;GO:0005769|early endosome;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0031226|intrinsic component of plasma membrane;GO:0043235|receptor complex;GO:0045121|membrane raft;GO:0046696|lipopolysaccharide receptor complex;GO:0048471|perinuclear region of cytoplasm;","GO:0001530|lipopolysaccharide binding;GO:0001875|lipopolysaccharide receptor activity;GO:0003953|NAD+ nucleosidase activity;GO:0004888|transmembrane signaling receptor activity;GO:0005102|signaling receptor binding;GO:0005515|protein binding;GO:0038023|signaling receptor activity;GO:0042802|identical protein binding;GO:0043548|phosphatidylinositol 3-kinase binding;GO:0046982|protein heterodimerization activity;GO:0050135|NAD(P)+ nucleosidase activity;GO:0061809|NAD+ nucleotidase, cyclic ADP-ribose generating;","K10160","TLR4, CD284; toll-like receptor 4"]
["ENSRNOG00000019112",96,8.07698579,44,2.83053928,2.853514822,1.512740057,{"v":1.92E-9,"d":"1.92E-09"},{"v":2.9e-09,"d":"2.90E-09"},"up","yes","Chp2","protein_coding","chr1:176757876-176772139:+","gi|672037923|ref|XP_008757967.1|",1320,{"v":1e-178,"d":"1.00E-178"},"PREDICTED: calcineurin B homologous protein 2 isoform X2 [Rattus norvegicus]","gi|672037922|ref|XM_008759745.1|",1354,0,"PREDICTED: Rattus norvegicus calcineurin-like EF hand protein 2 (Chp2), transcript variant X1, mRNA","Q810D1",395,{"v":1E-134,"d":"1.00E-134"},"Calcineurin B homologous protein 2","YKL190w",113,{"v":3E-28,"d":"3.00E-28"},"COG5126","pfam13499","EF-hand_7","EF-hand domain pair.","GO:0006883|cellular sodium ion homeostasis;GO:0008284|positive regulation of cell proliferation;GO:0010922|positive regulation of phosphatase activity;GO:0015031|protein transport;GO:0030641|regulation of cellular pH;GO:0042307|positive regulation of protein import into nucleus;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0070886|positive regulation of calcineurin-NFAT signaling cascade;GO:0071277|cellular response to calcium ion;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0009898|cytoplasmic side of plasma membrane;","GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0019904|protein domain specific binding;","K17611","CHP2; calcineurin B homologous protein 2"]
["ENSRNOG00000021546",31,2.608193328,2,0.128660876,20.27184488,4.341405485,{"v":2e-09,"d":"2.00E-09"},{"v":3.01e-09,"d":"3.01E-09"},"up","yes","Sit1","protein_coding","chr5:57740218-57741838:-","gi|66730477|ref|NP_001019515.1|",859,{"v":1e-111,"d":"1.00E-111"},"signaling threshold-regulating transmembrane adapter 1 [Rattus norvegicus]","gi|66730476|ref|NM_001024344.1|",1198,0,"Rattus norvegicus signaling threshold regulating transmembrane adaptor 1 (Sit1), mRNA","Q5M869",335,{"v":4e-113,"d":"4.00E-113"},"Signaling threshold-regulating transmembrane adapter 1",".",".",".",".","pfam15330","SIT","SHP2-interacting transmembrane adaptor protein, SIT. SIT, or SHP2-interacting transmembrane adaptor protein, is a disulfide-linked dimer that regulates human T Cell activation.","GO:0002250|adaptive immune response;GO:0007165|signal transduction;GO:0043029|T cell homeostasis;GO:0050863|regulation of T cell activation;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0019900|kinase binding;",".","."]
["ENSRNOG00000017193",66,5.552927731,22,1.41526964,3.92358288,1.972171675,{"v":2.05e-09,"d":"2.05E-09"},{"v":3.08e-09,"d":"3.08E-09"},"up","yes","Lingo1","protein_coding","chr8:57010007-57196544:-","gi|213688408|ref|NP_001094192.1|",3045,0,"leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 precursor [Rattus norvegicus]","gi|672062025|ref|XM_008766270.1|",3129,0,"PREDICTED: Rattus norvegicus leucine rich repeat and Ig domain containing 1 (Lingo1), transcript variant X1, mRNA","Q96FE5",1167,0,"Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1","alr0124_1",66.2,{"v":8e-10,"d":"8.00E-10"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0021954|central nervous system neuron development;GO:0031175|neuron projection development;GO:0043491|protein kinase B signaling;GO:0048715|negative regulation of oligodendrocyte differentiation;","GO:0005615|extracellular space;GO:0016021|integral component of membrane;GO:0031012|extracellular matrix;","GO:0005154|epidermal growth factor receptor binding;","K23533","LINGO, LRRN6; leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein"]
["ENSRNOG00000013748",29,2.439922791,1,0.064330438,37.92796784,5.24519017,{"v":2.06e-09,"d":"2.06E-09"},{"v":3.1E-9,"d":"3.10E-09"},"up","yes","Trem3","protein_coding","chr9:12749852-12760779:-","gi|300797456|ref|NP_001178510.1|",922,{"v":5e-119,"d":"5.00E-119"},"triggering receptor expressed on myeloid cells 3 precursor [Rattus norvegicus]","gi|300797455|ref|NM_001191581.1|",893,0,"Rattus norvegicus triggering receptor expressed on myeloid cells 3 (Trem3), mRNA","Q9JKE2",100,{"v":2e-22,"d":"2.00E-22"},"Triggering receptor expressed on myeloid cells 1",".",".",".",".","pfam02666","PS_Dcarbxylase","Phosphatidylserine decarboxylase. This is a family of phosphatidylserine decarboxylases, EC:4.1.1.65.  These enzymes catalyse the reaction: Phosphatidyl-L-serine <=> phosphatidylethanolamine + CO2. Phosphatidylserine decarboxylase plays a central role in the biosynthesis of aminophospholipids by converting phosphatidylserine to phosphatidylethanolamine.","GO:0002367|cytokine production involved in immune response;GO:0030593|neutrophil chemotaxis;GO:0032602|chemokine production;GO:0045089|positive regulation of innate immune response;GO:0070945|neutrophil mediated killing of gram-negative bacterium;GO:0072672|neutrophil extravasation;","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000006620",45,3.786087089,9,0.578973944,6.5393048,2.70913727,{"v":2.18e-09,"d":"2.18E-09"},{"v":3.27e-09,"d":"3.27E-09"},"up","yes","Xcr1","protein_coding","chr8:123479590-123487226:-","gi|157822209|ref|NP_001100341.1|",1587,0,"chemokine XC receptor 1 [Rattus norvegicus]","gi|157822208|ref|NM_001106871.1|",4240,0,"Rattus norvegicus chemokine (C motif) receptor 1 (Xcr1), mRNA","Q9R0M1",486,{"v":4e-158,"d":"4.00E-158"},"Chemokine XC receptor 1",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0006935|chemotaxis;GO:0006955|immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0019722|calcium-mediated signaling;GO:0034097|response to cytokine;GO:0051209|release of sequestered calcium ion into cytosol;GO:0060326|cell chemotaxis;GO:0070098|chemokine-mediated signaling pathway;","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0016493|C-C chemokine receptor activity;GO:0019957|C-C chemokine binding;","K04193","XCR1; XC chemokine receptor 1"]
["ENSRNOG00000015184",85,7.151497835,36,2.315895775,3.088005045,1.626675109,{"v":2.58e-09,"d":"2.58E-09"},{"v":3.83e-09,"d":"3.83E-09"},"up","yes","Clic3","protein_coding","chr3:8272097-8274018:+","gi|672044646|ref|XP_008759806.1|",1416,0,"PREDICTED: chloride intracellular channel protein 3 isoform X1 [Rattus norvegicus]","gi|672044645|ref|XM_008761584.1|",1460,0,"PREDICTED: Rattus norvegicus chloride intracellular channel 3 (Clic3), transcript variant X1, mRNA","Q9D7P7",441,{"v":5e-152,"d":"5.00E-152"},"Chloride intracellular channel protein 3",".",".",".",".","pfam13409","GST_N_2","Glutathione S-transferase, N-terminal domain. This family is closely related to pfam02798.","GO:0006749|glutathione metabolic process;GO:0006821|chloride transport;GO:0034220|ion transmembrane transport;GO:0034765|regulation of ion transmembrane transport;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0016020|membrane;GO:0016604|nuclear body;GO:0034707|chloride channel complex;","GO:0005244|voltage-gated ion channel activity;GO:0005254|chloride channel activity;","K05023","CLIC3; chloride intracellular channel protein 3"]
["ENSRNOG00000060246",41,3.449546015,7,0.450313067,7.66032848,2.937406257,{"v":2.64E-9,"d":"2.64E-09"},{"v":3.92e-09,"d":"3.92E-09"},"up","yes","Klrd1","protein_coding","chr4:163045067-163056518:+","gi|6981136|ref|NP_036877.1|",886,{"v":6e-115,"d":"6.00E-115"},"natural killer cells antigen CD94 [Rattus norvegicus]","gi|55926195|ref|NM_012745.2|",1347,0,"Rattus norvegicus killer cell lectin like receptor D1 (Klrd1), mRNA","O35778",345,{"v":2E-116,"d":"2.00E-116"},"Natural killer cells antigen CD94",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0001915|negative regulation of T cell mediated cytotoxicity;GO:0002223|stimulatory C-type lectin receptor signaling pathway;GO:0002228|natural killer cell mediated immunity;GO:0002250|adaptive immune response;GO:0008150|biological_process;GO:0045953|negative regulation of natural killer cell mediated cytotoxicity;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;","GO:0005575|cellular_component;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0043235|receptor complex;","GO:0003674|molecular_function;GO:0023024|MHC class I protein complex binding;GO:0023030|MHC class Ib protein binding, via antigen binding groove;GO:0030246|carbohydrate binding;GO:1990405|protein antigen binding;","K06516","KLRD1, CD94; killer cell lectin-like receptor subfamily D member 1"]
["ENSRNOG00000070065",41,3.449546015,7,0.450313067,7.66032848,2.937406257,{"v":2.64E-9,"d":"2.64E-09"},{"v":3.92e-09,"d":"3.92E-09"},"up","yes","ENSRNOG00000070065","lncRNA","chr2:20869527-20870649:+","gi|149039003|gb|EDL93223.1|",527,{"v":4e-63,"d":"4.00E-63"},"adenylate kinase 1, isoform CRA_b [Rattus norvegicus]","gi|467091434|ref|NM_024349.3|",1067,0,"Rattus norvegicus adenylate kinase 1 (Ak1), mRNA",".",".",".",".",".",".",".",".","pfam03441","FAD_binding_7","FAD binding domain of DNA photolyase.",".",".",".",".","."]
["ENSRNOG00000068539",104,8.750067939,51,3.280852347,2.667010585,1.415223551,{"v":2.74e-09,"d":"2.74E-09"},{"v":4.07e-09,"d":"4.07E-09"},"up","yes","ENSRNOG00000068539","lncRNA","chr1:20229465-20235866:-","gi|149062621|gb|EDM13044.1|",131,{"v":9e-06,"d":"9.00E-06"},"rCG63645 [Rattus norvegicus]","gi|755481919|ref|XR_392793.2|",577,0,"PREDICTED: Mus musculus predicted gene, 36313 (Gm36313), transcript variant X2, ncRNA",".",".",".",".",".",".",".",".","pfam07999","RHSP","Retrotransposon hot spot protein. Members of this family are retrotransposon hot spot proteins. They are associated with polymorphic subtelomeric regions in Trypanosoma. These proteins contain a P-loop motif.",".",".",".",".","."]
["ENSRNOG00000033064",48,4.038492895,11,0.70763482,5.707029644,2.512740057,{"v":3.03e-09,"d":"3.03E-09"},{"v":4.48e-09,"d":"4.48E-09"},"up","yes","Edil3","protein_coding","chr2:19890373-20405008:+","gi|392338494|ref|XP_003753552.1|",2521,0,"PREDICTED: EGF-like repeat and discoidin I-like domain-containing protein 3 [Rattus norvegicus]","gi|672015252|ref|XM_003753504.3|",4645,0,"PREDICTED: Rattus norvegicus EGF-like repeats and discoidin I-like domains 3 (Edil3), mRNA","O35474",947,0,"EGF-like repeat and discoidin I-like domain-containing protein 3",".",".",".",".","pfam00754","F5_F8_type_C","F5/8 type C domain. This domain is also known as the discoidin (DS) domain family.","GO:0007155|cell adhesion;GO:0010811|positive regulation of cell-substrate adhesion;",".","GO:0005509|calcium ion binding;","K24464","EDIL3; EGF-like repeat and discoidin I-like domain-containing protein 3"]
["ENSRNOG00000031540",158,13.29337245,98,6.304382942,2.10859216,1.076280079,{"v":3.4e-09,"d":"3.40E-09"},{"v":5.01e-09,"d":"5.01E-09"},"up","yes","ENSRNOG00000031540","protein_coding","chr13:83117297-83118233:+","gi|84000579|ref|NP_071945.3|",602,{"v":2e-74,"d":"2.00E-74"},"ferritin light chain 1 [Rattus norvegicus]","gi|228480381|gb|AC111734.5|",588,0,"Rattus norvegicus CH230-184H10 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P02793",236,{"v":6e-76,"d":"6.00E-76"},"Ferritin light chain 1",".",".",".",".","pfam00210","Ferritin","Ferritin-like domain. This family contains ferritins and other ferritin-like proteins such as members of the DPS family and bacterioferritins.","GO:0006826|iron ion transport;GO:0006880|intracellular sequestering of iron ion;","GO:0005737|cytoplasm;","GO:0008198|ferrous iron binding;GO:0008199|ferric iron binding;",".","."]
["ENSRNOG00000001312",159,13.37750771,99,6.36871338,2.100503966,1.07073551,{"v":3.53E-9,"d":"3.53E-09"},{"v":5.2e-09,"d":"5.20E-09"},"up","yes","Pdgfa","protein_coding","chr12:15645541-15666497:+","gi|564378363|ref|XP_006248981.1|",880,{"v":1e-113,"d":"1.00E-113"},"PREDICTED: platelet-derived growth factor subunit A isoform X1 [Rattus norvegicus]","gi|38197601|gb|BC061731.1|",1372,0,"Rattus norvegicus platelet-derived growth factor alpha polypeptide, mRNA (cDNA clone MGC:72268 IMAGE:5598667), complete cds","P28576",343,{"v":4e-115,"d":"4.00E-115"},"Platelet-derived growth factor subunit A",".",".",".",".","pfam04692","PDGF_N","Platelet-derived growth factor, N terminal region. This family consists of the amino terminal regions of platelet-derived growth factor (PDGF, pfam00341) A and B chains.","GO:0001525|angiogenesis;GO:0001666|response to hypoxia;GO:0001942|hair follicle development;GO:0002053|positive regulation of mesenchymal cell proliferation;GO:0008284|positive regulation of cell proliferation;GO:0008584|male gonad development;GO:0009410|response to xenobiotic stimulus;GO:0009611|response to wounding;GO:0009887|animal organ morphogenesis;GO:0010033|response to organic substance;GO:0010035|response to inorganic substance;GO:0010512|negative regulation of phosphatidylinositol biosynthetic process;GO:0010544|negative regulation of platelet activation;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0014910|regulation of smooth muscle cell migration;GO:0030031|cell projection assembly;GO:0030036|actin cytoskeleton organization;GO:0030335|positive regulation of cell migration;GO:0031954|positive regulation of protein autophosphorylation;GO:0032355|response to estradiol;GO:0032526|response to retinoic acid;GO:0035793|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway;GO:0042060|wound healing;GO:0043406|positive regulation of MAP kinase activity;GO:0043410|positive regulation of MAPK cascade;GO:0043588|skin development;GO:0048008|platelet-derived growth factor receptor signaling pathway;GO:0048146|positive regulation of fibroblast proliferation;GO:0048286|lung alveolus development;GO:0048565|digestive tract development;GO:0048839|inner ear development;GO:0050730|regulation of peptidyl-tyrosine phosphorylation;GO:0050919|negative chemotaxis;GO:0051781|positive regulation of cell division;GO:0051897|positive regulation of protein kinase B signaling;GO:0060348|bone development;GO:0060683|regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:1990401|embryonic lung development;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005902|microvillus;GO:0009986|cell surface;GO:0016020|membrane;","GO:0005161|platelet-derived growth factor receptor binding;GO:0005518|collagen binding;GO:0008083|growth factor activity;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0046982|protein heterodimerization activity;GO:0048407|platelet-derived growth factor binding;GO:0070851|growth factor receptor binding;","K04359","PDGFA; platelet-derived growth factor subunit A"]
["ENSRNOG00000025925",46,3.870222358,10,0.643304382,6.016160416,2.588843036,{"v":3.57e-09,"d":"3.57E-09"},{"v":5.26e-09,"d":"5.26E-09"},"up","yes","Txk","protein_coding","chr14:35463944-35519448:+","gi|66730395|ref|NP_001019426.1|",2728,0,"tyrosine-protein kinase TXK [Rattus norvegicus]","gi|66730394|ref|NM_001024255.1|",2281,0,"Rattus norvegicus TXK tyrosine kinase (Txk), mRNA","P42682",958,0,"Tyrosine-protein kinase TXK",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001819|positive regulation of cytokine production;GO:0001865|NK T cell differentiation;GO:0002250|adaptive immune response;GO:0006468|protein phosphorylation;GO:0007202|activation of phospholipase C activity;GO:0007229|integrin-mediated signaling pathway;GO:0008150|biological_process;GO:0010468|regulation of gene expression;GO:0010543|regulation of platelet activation;GO:0032729|positive regulation of interferon-gamma production;GO:0038083|peptidyl-tyrosine autophosphorylation;GO:0042246|tissue regeneration;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046777|protein autophosphorylation;GO:0050852|T cell receptor signaling pathway;GO:0060335|positive regulation of interferon-gamma-mediated signaling pathway;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0003674|molecular_function;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0005524|ATP binding;","K08016","TXK, RLK; tyrosine-protein kinase TXK [EC:2.7.10.2]"]
["ENSRNOG00000069051",83,6.983227298,35,2.251565336,3.101498848,1.632965589,{"v":3.58E-9,"d":"3.58E-09"},{"v":5.27e-09,"d":"5.27E-09"},"up","yes","ENSRNOG00000069051","lncRNA","chr14:83415689-83420637:+","gi|149036607|gb|EDL91225.1|",144,{"v":2E-8,"d":"2.00E-08"},"rCG56442 [Rattus norvegicus]","gi|672028133|ref|XR_594132.1|",2177,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103693171 (LOC103693171), ncRNA",".",".",".",".",".",".",".",".","pfam13030","DUF3891","Protein of unknown function (DUF3891). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and archaea. Proteins in this family are approximately 250 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000066282",107,9.002473745,54,3.473843662,2.591502273,1.373788659,{"v":3.7E-9,"d":"3.70E-09"},{"v":5.43e-09,"d":"5.43E-09"},"up","yes","ENSRNOG00000066282","lncRNA","chr6:123705846-123712737:-","gi|149060974|gb|EDM11584.1|",131,{"v":1e-05,"d":"1.00E-05"},"rCG30389 [Rattus norvegicus]","gi|556695510|ref|NR_104436.1|",792,0,"Mus musculus calmin (Clmn), transcript variant 5, non-coding RNA",".",".",".",".",".",".",".",".","pfam04216","FdhE","Protein involved in formate dehydrogenase formation. The function of these proteins is unknown. They may possibly be involved in the formation of formate dehydrogenase.",".",".",".",".","."]
["ENSRNOG00000069083",107,9.002473745,54,3.473843662,2.591502273,1.373788659,{"v":3.7E-9,"d":"3.70E-09"},{"v":5.43e-09,"d":"5.43E-09"},"up","yes","ENSRNOG00000069083","lncRNA","chr12:34123824-34128516:-","gi|149038339|gb|EDL92699.1|",227,{"v":5e-18,"d":"5.00E-18"},"rCG63222 [Rattus norvegicus]","gi|169235020|gb|AC104314.8|",3572,0,"Rattus norvegicus BAC CH230-136I5 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam02028","BCCT","BCCT family transporter.",".",".",".",".","."]
["ENSRNOG00000036837",80,6.730821492,33,2.12290446,3.170572024,1.66474315,{"v":4.23e-09,"d":"4.23E-09"},{"v":6.18e-09,"d":"6.18E-09"},"up","yes","Nfe2","protein_coding","chr7:134382761-134390108:-","gi|149031876|gb|EDL86788.1|",1813,0,"rCG50844 [Rattus norvegicus]","gi|672060219|ref|XM_006242432.2|",1687,0,"PREDICTED: Rattus norvegicus nuclear factor, erythroid 2 (Nfe2), transcript variant X2, mRNA","Q6AYT2",657,0,"Transcription factor NF-E2 45 kDa subunit",".",".",".",".","pfam03131","bZIP_Maf","bZIP Maf transcription factor. Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerization and DNA binding property. Thus, this family is probably related to pfam00170. This family also includes the DNA_binding domain of Skn-1, this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0007267|cell-cell signaling;GO:0008285|negative regulation of cell proliferation;GO:0010467|gene expression;GO:0010468|regulation of gene expression;GO:0030502|negative regulation of bone mineralization;GO:0034242|negative regulation of syncytium formation by plasma membrane fusion;GO:0060716|labyrinthine layer blood vessel development;GO:2000758|positive regulation of peptidyl-lysine acetylation;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0016605|PML body;GO:0032993|protein-DNA complex;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987|proximal promoter sequence-specific DNA binding;GO:0003677|DNA binding;GO:0042802|identical protein binding;GO:0047485|protein N-terminus binding;GO:0050699|WW domain binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09039","NFE2; nuclear factor erythroid 2"]
["ENSRNOG00000017429",98,8.245256327,47,3.023530595,2.727029236,1.447330167,{"v":4.35e-09,"d":"4.35E-09"},{"v":6.36e-09,"d":"6.36E-09"},"up","yes","Lat","protein_coding","chr1:180936534-180941578:-","gi|13540669|ref|NP_110480.1|",829,{"v":3e-106,"d":"3.00E-106"},"linker for activation of T-cells family member 1 [Rattus norvegicus]","gi|13540668|ref|NM_030853.1|",1188,0,"Rattus norvegicus linker for activation of T cells (Lat), mRNA","O70601",323,{"v":1E-107,"d":"1.00E-107"},"Linker for activation of T-cells family member 1",".",".",".",".","pfam15234","LAT","Linker for activation of T-cells.","GO:0002250|adaptive immune response;GO:0002260|lymphocyte homeostasis;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007229|integrin-mediated signaling pathway;GO:0007265|Ras protein signal transduction;GO:0010467|gene expression;GO:0019722|calcium-mediated signaling;GO:0035556|intracellular signal transduction;GO:0043303|mast cell degranulation;GO:0045860|positive regulation of protein kinase activity;GO:0048872|homeostasis of number of cells;GO:0050863|regulation of T cell activation;","GO:0001772|immunological synapse;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0008180|COP9 signalosome;GO:0016021|integral component of membrane;","GO:0019901|protein kinase binding;GO:0030159|receptor signaling complex scaffold activity;","K07362","LAT; linker for activation of T cells"]
["ENSRNOG00000020884",49,4.122628164,12,0.771965258,5.340432254,2.416956518,{"v":4.64e-09,"d":"4.64E-09"},{"v":6.76e-09,"d":"6.76E-09"},"up","yes","Cd6","protein_coding","chr1:207442877-207481634:-","gi|58477106|gb|AAH89767.1|",2923,0,"Cd6 protein [Rattus norvegicus]","gi|58477105|gb|BC089767.1|",3426,0,"Rattus norvegicus Cd6 molecule, mRNA (cDNA clone MGC:108551 IMAGE:7383438), complete cds","Q61003",933,0,"T-cell differentiation antigen CD6",".",".",".",".","pfam00530","SRCR","Scavenger receptor cysteine-rich domain. These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.","GO:0001771|immunological synapse formation;GO:0001934|positive regulation of protein phosphorylation;GO:0002438|acute inflammatory response to antigenic stimulus;GO:0006897|endocytosis;GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0032496|response to lipopolysaccharide;GO:0042102|positive regulation of T cell proliferation;GO:1900017|positive regulation of cytokine production involved in inflammatory response;","GO:0001772|immunological synapse;GO:0009897|external side of plasma membrane;GO:0031226|intrinsic component of plasma membrane;GO:0044214|spanning component of plasma membrane;","GO:0001530|lipopolysaccharide binding;GO:0005044|scavenger receptor activity;GO:0005515|protein binding;GO:0019901|protein kinase binding;GO:0042802|identical protein binding;GO:0070891|lipoteichoic acid binding;","K06456","CD6; T-cell surface glycoprotein CD6"]
["ENSRNOG00000064585",57,4.795710313,17,1.093617449,4.385180866,2.132636348,{"v":4.68e-09,"d":"4.68E-09"},{"v":6.82E-9,"d":"6.82E-09"},"up","yes","Dcdc2b","protein_coding","chr5:141951031-141967365:-","gi|564353124|ref|XP_006239049.1|",2018,0,"PREDICTED: LOW QUALITY PROTEIN: IQ domain-containing protein C [Rattus norvegicus]","gi|672054246|ref|XM_006238987.2|",1985,0,"PREDICTED: Rattus norvegicus IQ motif containing C (Iqcc), mRNA",".",".",".",".",".",".",".",".","pfam13270","DUF4061","Domain of unknown function (DUF4061). This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is approximately 90 amino acids in length. There is a conserved AFG sequence motif.",".",".",".",".","."]
["ENSRNOG00000001908",94,7.908715253,44,2.83053928,2.794066597,1.482366408,{"v":4.83e-09,"d":"4.83E-09"},{"v":7.03e-09,"d":"7.03E-09"},"up","yes","Klhl6","protein_coding","chr11:80970917-81009677:+","gi|157786760|ref|NP_001099337.1|",3338,0,"kelch-like protein 6 [Rattus norvegicus]","gi|157786759|ref|NM_001105867.1|",2415,0,"Rattus norvegicus kelch-like family member 6 (Klhl6), mRNA","Q6V595",1277,0,"Kelch-like protein 6",".",".",".",".","pfam07707","BACK","BTB And C-terminal Kelch. This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).","GO:0002467|germinal center formation;GO:0009617|response to bacterium;GO:0050853|B cell receptor signaling pathway;",".",".","K10444","KLHL6; kelch-like protein 6"]
["ENSRNOG00000018163",36,3.028869671,5,0.321652191,9.416598913,3.235206081,{"v":5.41e-09,"d":"5.41E-09"},{"v":7.84e-09,"d":"7.84E-09"},"up","yes","Ipcef1","protein_coding","chr1:43269202-43427969:-","gi|282847440|ref|NP_001164270.1|",1878,0,"interactor protein for cytohesin exchange factors 1 [Rattus norvegicus]","gi|755532676|ref|XM_011243080.1|",2018,0,"PREDICTED: Mus musculus interaction protein for cytohesin exchange factors 1 (Ipcef1), transcript variant X1, mRNA","Q80VL0",728,0,"Interactor protein for cytohesin exchange factors 1",".",".",".",".","pfam00169","PH","PH domain. PH stands for pleckstrin homology.",".","GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0005515|protein binding;GO:0019904|protein domain specific binding;","K23795","IPCEF1; interactor protein for cytohesin exchange factors 1"]
["ENSRNOG00000003310",142,11.94720815,85,5.468087246,2.184897133,1.127565358,{"v":5.93E-9,"d":"5.93E-09"},{"v":8.58e-09,"d":"8.58E-09"},"up","yes","Tmem63a","protein_coding","chr13:92663968-92696183:+","gi|564382020|ref|XP_006250426.1|",3940,0,"PREDICTED: CSC1-like protein 1 isoform X2 [Rattus norvegicus]","gi|672075044|ref|XM_006250364.2|",3431,0,"PREDICTED: Rattus norvegicus transmembrane protein 63a (Tmem63a), transcript variant X1, mRNA","Q91YT8",1446,0,"CSC1-like protein 1",".",".",".",".","pfam02714","DUF221","Domain of unknown function DUF221. This family consists of hypothetical transmembrane proteins none of which have any function, the aligned region is at 538 residues at maximum length.","GO:0098655|cation transmembrane transport;","GO:0005765|lysosomal membrane;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0034451|centriolar satellite;GO:0043231|intracellular membrane-bounded organelle;","GO:0003676|nucleic acid binding;GO:0005227|calcium activated cation channel activity;GO:0008381|mechanosensitive ion channel activity;GO:1990760|osmolarity-sensing cation channel activity;","K21989","TMEM63, CSC1; calcium permeable stress-gated cation channel"]
["ENSRNOG00000070011",102,8.581797402,51,3.280852347,2.61572192,1.387209175,{"v":6.62e-09,"d":"6.62E-09"},{"v":9.53E-9,"d":"9.53E-09"},"up","yes","ENSRNOG00000070011","lncRNA","chr18:55095230-55118825:-","gi|149064411|gb|EDM14614.1|",541,{"v":1E-58,"d":"1.00E-58"},"rCG46786 [Rattus norvegicus]","gi|56044724|gb|AC115691.8|",1730,0,"Mus musculus chromosome 18, clone RP24-286B14, complete sequence",".",".",".",".",".",".",".",".","pfam12234","Rav1p_C","RAVE protein 1 C terminal. This domain family is found in eukaryotes, and is typically between 621 and 644 amino acids in length. This family is the C terminal region of the protein RAVE (regulator of the ATPase of vacuolar and endosomal membranes). Rav1p is involved in regulating the glucose dependent assembly and disassembly of vacuolar ATPase V1 and V0 subunits.",".",".",".",".","."]
["ENSRNOG00000020849",56,4.711575044,17,1.093617449,4.308247868,2.107101256,{"v":8.29e-09,"d":"8.29E-09"},{"v":1.18E-8,"d":"1.18E-08"},"up","yes","Hcst","protein_coding","chr1:85676979-85679012:-","gi|564327406|ref|XP_006228847.1|",291,{"v":3e-30,"d":"3.00E-30"},"PREDICTED: hematopoietic cell signal transducer isoform X1 [Rattus norvegicus]","gi|354796740|gb|JN961241.1|",278,{"v":5e-142,"d":"5.00E-142"},"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Hcst:tm1a(KOMP)Wtsi; transgenic","Q6X9T8",116,{"v":9e-32,"d":"9.00E-32"},"Hematopoietic cell signal transducer",".",".",".",".","pfam07213","DAP10","DAP10 membrane protein. This family consists of several mammalian DAP10 membrane proteins. In activated mouse natural killer (NK) cells, the NKG2D receptor associates with two intracellular adaptors, DAP10 and DAP12, which trigger phosphatidyl inositol 3 kinase (PI3K) and Syk family protein tyrosine kinases, respectively. It has been suggested that the DAP10-PI3K pathway is sufficient to initiate NKG2D-mediated killing of target cells.","GO:0006468|protein phosphorylation;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0050776|regulation of immune response;","GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0005102|signaling receptor binding;GO:0043548|phosphatidylinositol 3-kinase binding;","K07988","HCST, DAP10; hematopoietic cell signal transducer"]
["ENSRNOG00000019142",118,9.9279617,65,4.181478482,2.374270666,1.247484411,{"v":9.05E-9,"d":"9.05E-09"},{"v":1.28E-8,"d":"1.28E-08"},"up","yes","Fas","protein_coding","chr1:231798960-231832591:+","gi|59624977|ref|NP_631933.2|",1602,0,"tumor necrosis factor receptor superfamily member 6 precursor [Rattus norvegicus]","gi|59624976|ref|NM_139194.2|",2541,0,"Rattus norvegicus Fas cell surface death receptor (Fas), mRNA","Q63199",619,0,"Tumor necrosis factor receptor superfamily member 6",".",".",".",".","pfam00531","Death","Death domain.","GO:0001552|ovarian follicle atresia;GO:0001666|response to hypoxia;GO:0001934|positive regulation of protein phosphorylation;GO:0006915|apoptotic process;GO:0006924|activation-induced cell death of T cells;GO:0006925|inflammatory cell apoptotic process;GO:0006955|immune response;GO:0007165|signal transduction;GO:0007283|spermatogenesis;GO:0007568|aging;GO:0007623|circadian rhythm;GO:0008625|extrinsic apoptotic signaling pathway via death domain receptors;GO:0009410|response to xenobiotic stimulus;GO:0009636|response to toxic substance;GO:0010035|response to inorganic substance;GO:0010467|gene expression;GO:0010468|regulation of gene expression;GO:0010626|negative regulation of Schwann cell proliferation;GO:0010876|lipid localization;GO:0010883|regulation of lipid storage;GO:0010942|positive regulation of cell death;GO:0014070|response to organic cyclic compound;GO:0019724|B cell mediated immunity;GO:0021537|telencephalon development;GO:0031104|dendrite regeneration;GO:0031334|positive regulation of protein complex assembly;GO:0031667|response to nutrient levels;GO:0032496|response to lipopolysaccharide;GO:0032872|regulation of stress-activated MAPK cascade;GO:0033209|tumor necrosis factor-mediated signaling pathway;GO:0034097|response to cytokine;GO:0034198|cellular response to amino acid starvation;GO:0036337|Fas signaling pathway;GO:0042127|regulation of cell proliferation;GO:0042698|ovulation cycle;GO:0042981|regulation of apoptotic process;GO:0043009|chordate embryonic development;GO:0043029|T cell homeostasis;GO:0043065|positive regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0043280|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043434|response to peptide hormone;GO:0043525|positive regulation of neuron apoptotic process;GO:0043627|response to estrogen;GO:0045060|negative thymic T cell selection;GO:0045471|response to ethanol;GO:0045619|regulation of lymphocyte differentiation;GO:0045637|regulation of myeloid cell differentiation;GO:0046898|response to cycloheximide;GO:0048536|spleen development;GO:0050869|negative regulation of B cell activation;GO:0051384|response to glucocorticoid;GO:0051402|neuron apoptotic process;GO:0060135|maternal process involved in female pregnancy;GO:0070227|lymphocyte apoptotic process;GO:0070301|cellular response to hydrogen peroxide;GO:0070848|response to growth factor;GO:0071234|cellular response to phenylalanine;GO:0071260|cellular response to mechanical stimulus;GO:0071279|cellular response to cobalt ion;GO:0071285|cellular response to lithium ion;GO:0071333|cellular response to glucose stimulus;GO:0071345|cellular response to cytokine stimulus;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071391|cellular response to estrogen stimulus;GO:0071407|cellular response to organic cyclic compound;GO:0071455|cellular response to hyperoxia;GO:0071456|cellular response to hypoxia;GO:0071464|cellular response to hydrostatic pressure;GO:0097049|motor neuron apoptotic process;GO:0097190|apoptotic signaling pathway;GO:0097191|extrinsic apoptotic signaling pathway;GO:0097192|extrinsic apoptotic signaling pathway in absence of ligand;GO:0097284|hepatocyte apoptotic process;GO:0097421|liver regeneration;GO:0097527|necroptotic signaling pathway;GO:1900148|negative regulation of Schwann cell migration;GO:1902617|response to fluoride;GO:2001235|positive regulation of apoptotic signaling pathway;GO:2001269|positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0016604|nuclear body;GO:0030141|secretory granule;GO:0031264|death-inducing signaling complex;GO:0031265|CD95 death-inducing signaling complex;GO:0042383|sarcolemma;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0045121|membrane raft;GO:0048471|perinuclear region of cytoplasm;GO:0097440|apical dendrite;","GO:0002020|protease binding;GO:0004888|transmembrane signaling receptor activity;GO:0005031|tumor necrosis factor-activated receptor activity;GO:0005515|protein binding;GO:0005516|calmodulin binding;GO:0019900|kinase binding;GO:0038023|signaling receptor activity;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;","K04390","TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6"]
["ENSRNOG00000014452",100,8.413526865,50,3.216521909,2.61572192,1.387209175,{"v":9.3e-09,"d":"9.30E-09"},{"v":1.31E-8,"d":"1.31E-08"},"up","yes","Zfhx3","protein_coding","chr19:36630254-36881771:+","gi|672085073|ref|XP_008770789.1|",13553,0,"PREDICTED: zinc finger homeobox protein 3 isoform X2 [Rattus norvegicus]","gi|672085072|ref|XM_008772567.1|",11296,0,"PREDICTED: Rattus norvegicus zinc finger homeobox 3 (Zfhx3), transcript variant X2, mRNA","Q61329",5062,0,"Zinc finger homeobox protein 3","ECU06g0500",55.1,{"v":3e-07,"d":"3.00E-07"},"COG5576","pfam00046","Homeobox","Homeobox domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007420|brain development;GO:0032922|circadian regulation of gene expression;GO:0045662|negative regulation of myoblast differentiation;GO:0045663|positive regulation of myoblast differentiation;GO:0045664|regulation of neuron differentiation;GO:0045785|positive regulation of cell adhesion;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051726|regulation of cell cycle;GO:0071559|response to transforming growth factor beta;GO:1904059|regulation of locomotor rhythm;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005737|cytoplasm;GO:0016604|nuclear body;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0008270|zinc ion binding;GO:0019899|enzyme binding;","K09378","ZFHX3, ATBF1; zinc finger homeobox protein 3"]
["ENSRNOG00000052649",51,4.290898701,14,0.900626135,4.76435064,2.252279595,{"v":9.92e-09,"d":"9.92E-09"},{"v":1.4E-8,"d":"1.40E-08"},"up","yes","AABR07008309.1","lncRNA","chr2:52006086-52027865:+",".",".",".",".","gi|672041664|ref|XR_590927.1|",589,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103691468 (LOC103691468), transcript variant X2, ncRNA",".",".",".",".",".",".",".",".","pfam10032","Pho88","Phosphate transport (Pho88). Members of this family of proteins are involved in regulating inorganic phosphate transport, as well as telomere length regulation and maintenance.",".",".",".",".","."]
["ENSRNOG00000030494",35,2.944734403,5,0.321652191,9.155026721,3.194564097,{"v":1.06e-08,"d":"1.06E-08"},{"v":1.49e-08,"d":"1.49E-08"},"up","yes","AABR07072761.1","protein_coding","chr2:182254732-182255595:-","gi|62643868|ref|XP_574989.1|",1507,0,"PREDICTED: nuclear receptor-binding factor 2-like isoform X1 [Rattus norvegicus]","gi|672043547|ref|XM_574989.5|",864,0,"PREDICTED: Rattus norvegicus similar to nuclear receptor binding factor 2 (RGD1560263), transcript variant X1, mRNA","Q9QYK3",576,0,"Nuclear receptor-binding factor 2",".",".",".",".","pfam08961","DUF1875","Domain of unknown function (DUF1875). The MIT domain, found in Nuclear receptor-binding factor 2, has no known function.",".",".",".","K21246","NRBF2; nuclear receptor-binding factor 2"]
["ENSRNOG00000019614",82,6.899092029,36,2.315895775,2.979016631,1.574836178,{"v":1.1e-08,"d":"1.10E-08"},{"v":1.54e-08,"d":"1.54E-08"},"up","yes","Ptpn22","protein_coding","chr2:191366808-191414779:+","gi|157824150|ref|NP_001099930.1|",4102,0,"tyrosine-protein phosphatase non-receptor type 22 [Rattus norvegicus]","gi|157824149|ref|NM_001106460.1|",2747,0,"Rattus norvegicus protein tyrosine phosphatase, non-receptor type 22 (Ptpn22), mRNA","P29352",1358,0,"Tyrosine-protein phosphatase non-receptor type 22","SPAC19D5.01",120,{"v":4e-27,"d":"4.00E-27"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0002230|positive regulation of defense response to virus by host;GO:0002685|regulation of leukocyte migration;GO:0006470|protein dephosphorylation;GO:0010507|negative regulation of autophagy;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0030217|T cell differentiation;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0032481|positive regulation of type I interferon production;GO:0032496|response to lipopolysaccharide;GO:0032715|negative regulation of interleukin-6 production;GO:0032717|negative regulation of interleukin-8 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032727|positive regulation of interferon-alpha production;GO:0032728|positive regulation of interferon-beta production;GO:0032729|positive regulation of interferon-gamma production;GO:0032817|regulation of natural killer cell proliferation;GO:0034141|positive regulation of toll-like receptor 3 signaling pathway;GO:0034145|positive regulation of toll-like receptor 4 signaling pathway;GO:0034157|positive regulation of toll-like receptor 7 signaling pathway;GO:0034165|positive regulation of toll-like receptor 9 signaling pathway;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0035644|phosphoanandamide dephosphorylation;GO:0042307|positive regulation of protein import into nucleus;GO:0043508|negative regulation of JUN kinase activity;GO:0050730|regulation of peptidyl-tyrosine phosphorylation;GO:0050852|T cell receptor signaling pathway;GO:0050860|negative regulation of T cell receptor signaling pathway;GO:0050868|negative regulation of T cell activation;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070433|negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0071225|cellular response to muramyl dipeptide;GO:0071663|positive regulation of granzyme B production;GO:1901222|regulation of NIK/NF-kappaB signaling;GO:1902523|positive regulation of protein K63-linked ubiquitination;GO:1903169|regulation of calcium ion transmembrane transport;GO:1903753|negative regulation of p38MAPK cascade;GO:2000566|positive regulation of CD8-positive, alpha-beta T cell proliferation;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0009898|cytoplasmic side of plasma membrane;GO:0048471|perinuclear region of cytoplasm;","GO:0004725|protein tyrosine phosphatase activity;GO:0004726|non-membrane spanning protein tyrosine phosphatase activity;GO:0016791|phosphatase activity;GO:0017124|SH3 domain binding;GO:0019900|kinase binding;GO:0031625|ubiquitin protein ligase binding;GO:1990782|protein tyrosine kinase binding;","K18024","PTPN12_18_22; tyrosine-protein phosphatase non-receptor type 12/18/22 [EC:3.1.3.48]"]
["ENSRNOG00000004778",74,6.22600988,30,1.929913146,3.226057035,1.689771945,{"v":1.13E-8,"d":"1.13E-08"},{"v":1.58e-08,"d":"1.58E-08"},"up","yes","Cnga1","protein_coding","chr14:35567125-35605065:+","gi|2493742|sp|Q62927.1|CNGA1_RAT",3096,0,"RecName: Full=cGMP-gated cation channel alpha-1; AltName: Full=Cyclic nucleotide-gated cation channel 1; AltName: Full=Cyclic nucleotide-gated channel alpha-1; Short=CNG channel alpha-1; Short=CNG-1; Short=CNG1; AltName: Full=Cyclic nucleotide-gated channel, photoreceptor; AltName: Full=Rod photoreceptor cGMP-gated channel subunit alpha","gi|16758253|ref|NM_053497.1|",2103,0,"Rattus norvegicus cyclic nucleotide gated channel alpha 1 (Cnga1), mRNA","Q62927",1174,0,"cGMP-gated cation channel alpha-1",".",".",".",".","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0007283|spermatogenesis;GO:0007601|visual perception;GO:0051480|regulation of cytosolic calcium ion concentration;GO:0051899|membrane depolarization;GO:0098655|cation transmembrane transport;","GO:0001750|photoreceptor outer segment;GO:0005737|cytoplasm;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0017071|intracellular cyclic nucleotide activated cation channel complex;GO:0042622|photoreceptor outer segment membrane;GO:0043195|terminal bouton;","GO:0005221|intracellular cyclic nucleotide activated cation channel activity;GO:0005222|intracellular cAMP-activated cation channel activity;GO:0005223|intracellular cGMP-activated cation channel activity;GO:0030553|cGMP binding;","K04948","CNGA1; cyclic nucleotide gated channel alpha 1"]
["ENSRNOG00000009074",123,10.34863804,70,4.503130673,2.298098544,1.200440663,{"v":1.25e-08,"d":"1.25E-08"},{"v":1.74E-8,"d":"1.74E-08"},"up","yes","AABR07017902.1","protein_coding","chr15:27109504-27665579:+","gi|60551424|gb|AAH91200.1|",766,{"v":6e-90,"d":"6.00E-90"},"RGD1359684 protein [Rattus norvegicus]","gi|218511252|gb|AC097037.8|",3033,0,"Rattus norvegicus CH230-20D8 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P01849",223,{"v":5e-65,"d":"5.00E-65"},"T-cell receptor alpha chain C region",".",".",".",".","pfam09291","DUF1968","Domain of unknown function (DUF1968). Members of this family are found in mammalian T-cell antigen receptor, and adopt an immunoglobulin-like beta-sandwich fold, with seven strands in two beta-sheets in a Greek-key topology. Their exact function has not, as yet, been determined.",".",".",".",".","."]
["ENSRNOG00000032085",49,4.122628164,13,0.836295696,4.929629773,2.301479301,{"v":1.25e-08,"d":"1.25E-08"},{"v":1.75e-08,"d":"1.75E-08"},"up","yes","Dlec1","protein_coding","chr8:118826466-118873655:+","gi|564310825|ref|XP_006226675.1|",8962,0,"PREDICTED: deleted in lung and esophageal cancer protein 1 homolog isoform X3 [Rattus norvegicus]","gi|672023440|ref|XM_006226613.2|",5504,0,"PREDICTED: Rattus norvegicus deleted in lung and esophageal cancer 1 (Dlec1), transcript variant X3, mRNA","Q9Y238",2361,0,"Deleted in lung and esophageal cancer protein 1",".",".",".",".","pfam02803","Thiolase_C","Thiolase, C-terminal domain. Thiolase is reported to be structurally related to beta-ketoacyl synthase (pfam00109), and also chalcone synthase.","GO:0002357|defense response to tumor cell;GO:0007283|spermatogenesis;GO:0008150|biological_process;GO:0008285|negative regulation of cell proliferation;GO:0030154|cell differentiation;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0003674|molecular_function;GO:0043014|alpha-tubulin binding;GO:0048487|beta-tubulin binding;","K25548","DLEC1; deleted in lung and esophageal cancer protein 1"]
["ENSRNOG00000011284",110,9.254879551,59,3.795495853,2.438384841,1.285925839,{"v":1.33E-8,"d":"1.33E-08"},{"v":1.85E-8,"d":"1.85E-08"},"up","yes","Sgms2","protein_coding","chr2:219893572-219967546:-","gi|62078817|ref|NP_001014065.1|",1764,0,"phosphatidylcholine:ceramide cholinephosphotransferase 2 [Rattus norvegicus]","gi|672044215|ref|XM_006233311.2|",1662,0,"PREDICTED: Rattus norvegicus sphingomyelin synthase 2 (Sgms2), transcript variant X2, mRNA","Q4JM44",682,0,"Phosphatidylcholine:ceramide cholinephosphotransferase 2",".",".",".",".","pfam14360","PAP2_C","PAP2 superfamily C-terminal. This family is closely related to the C-terminal a region of PAP2.","GO:0006686|sphingomyelin biosynthetic process;GO:0016310|phosphorylation;GO:0030500|regulation of bone mineralization;GO:0046513|ceramide biosynthetic process;GO:1905373|ceramide phosphoethanolamine biosynthetic process;","GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0030173|integral component of Golgi membrane;GO:0030176|integral component of endoplasmic reticulum membrane;","GO:0002950|ceramide phosphoethanolamine synthase activity;GO:0016301|kinase activity;GO:0033188|sphingomyelin synthase activity;GO:0047493|ceramide cholinephosphotransferase activity;","K04714","SGMS; shingomyelin synthase [EC:2.7.8.27]"]
["ENSRNOG00000022490",111,9.33901482,60,3.859826291,2.419542776,1.274734445,{"v":1.43e-08,"d":"1.43E-08"},{"v":1.99E-8,"d":"1.99E-08"},"up","yes","ENSRNOG00000022490","protein_coding","chr3:13804033-13804473:-","gi|478495069|ref|XP_004421882.1|",583,{"v":3e-74,"d":"3.00E-74"},"PREDICTED: cytochrome c oxidase subunit 5A, mitochondrial [Ceratotherium simum simum]","gi|672016567|ref|XR_600114.1|",441,0,"PREDICTED: Rattus norvegicus Cytochrome c oxidase subunit 5A, mitochondrial-like (LOC100361008), misc_RNA","B0VYY3",227,{"v":3e-75,"d":"3.00E-75"},"Cytochrome c oxidase subunit 5A, mitochondrial",".",".",".",".","pfam02284","COX5A","Cytochrome c oxidase subunit Va. Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of cytochrome c oxidase subunit Va.",".",".",".",".","."]
["ENSRNOG00000004341",99,8.329391596,50,3.216521909,2.589564701,1.372709605,{"v":1.44E-8,"d":"1.44E-08"},{"v":2E-8,"d":"2.00E-08"},"up","yes","ENSRNOG00000004341","protein_coding","chr13:42188609-42201426:+","gi|281306791|ref|NP_001094258.1|",2615,0,"specifically androgen-regulated gene protein [Rattus norvegicus]","gi|281306790|ref|NM_001100788.1|",2866,0,"Rattus norvegicus similar to specifically androgen-regulated protein (LOC498222), mRNA","Q499V8",1011,0,"Specifically androgen-regulated gene protein",".",".",".",".","pfam15385","SARG","Specifically androgen-regulated gene protein. This family of proteins is found in eukaryotes, the function of this protein is still unknown but it is thought to be an androgen receptor. Protein expression is up-regulated in the presence of androgens, but not in the presence of glucocorticoids. SARG tends to be highly expressed in prostate tissue. Proteins in this family are typically between 340 and 587 amino acids in length. There is a conserved EETI sequence motif.",".","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;",".",".","."]
["ENSRNOG00000007078",58,4.879845581,19,1.222278326,3.992417668,1.997262656,{"v":1.47e-08,"d":"1.47E-08"},{"v":2.03E-8,"d":"2.03E-08"},"up","yes","Ccn4","protein_coding","chr7:98645182-98677248:+","gi|50926796|gb|AAH78787.1|",1525,0,"Wisp1 protein [Rattus norvegicus]","gi|166706547|gb|AC120745.5|",2049,0,"Rattus norvegicus BAC CH230-25E14 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q99PP0",515,{"v":3e-167,"d":"3.00E-167"},"WNT1-inducible-signaling pathway protein 1",".",".",".",".","pfam00219","IGFBP","Insulin-like growth factor binding protein.","GO:0001649|osteoblast differentiation;GO:0001817|regulation of cytokine production;GO:0007155|cell adhesion;GO:0007165|signal transduction;GO:0014911|positive regulation of smooth muscle cell migration;GO:0016055|Wnt signaling pathway;GO:0030177|positive regulation of Wnt signaling pathway;GO:0030316|osteoclast differentiation;GO:0032331|negative regulation of chondrocyte differentiation;GO:0042593|glucose homeostasis;GO:0045599|negative regulation of fat cell differentiation;GO:0045669|positive regulation of osteoblast differentiation;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0050729|positive regulation of inflammatory response;GO:0060348|bone development;GO:0060548|negative regulation of cell death;GO:0061051|positive regulation of cell growth involved in cardiac muscle cell development;GO:0090303|positive regulation of wound healing;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0031012|extracellular matrix;","GO:0003674|molecular_function;GO:0005178|integrin binding;GO:0005520|insulin-like growth factor binding;GO:0008201|heparin binding;","K22471","CCN4, WISP1; CCN family member 4"]
["ENSRNOG00000003468",94,7.908715253,46,2.959200157,2.67258544,1.41823607,{"v":1.49e-08,"d":"1.49E-08"},{"v":2.07E-8,"d":"2.07E-08"},"up","yes","Capn8","protein_coding","chr13:94253054-94316146:+","gi|28849961|ref|NP_579843.2|",3790,0,"calpain-8 [Rattus norvegicus]","gi|28849960|ref|NM_133309.2|",2402,0,"Rattus norvegicus calpain 8 (Capn8), mRNA","Q78EJ9",1464,0,"Calpain-8",".",".",".",".","pfam00648","Peptidase_C2","Calpain family cysteine protease.","GO:0006508|proteolysis;GO:0007586|digestion;GO:1990092|calcium-dependent self proteolysis;","GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;","GO:0004198|calcium-dependent cysteine-type endopeptidase activity;GO:0005509|calcium ion binding;GO:0042802|identical protein binding;","K08577","CAPN8; calpain-8 [EC:3.4.22.-]"]
["ENSRNOG00000002024",26,2.187516985,1,0.064330438,34.00438496,5.087648893,{"v":1.55E-8,"d":"1.55E-08"},{"v":2.15e-08,"d":"2.15E-08"},"up","yes","Epha5","protein_coding","chr14:23653393-24017317:+","gi|672075835|ref|XP_008768281.1|",5293,0,"PREDICTED: ephrin type-A receptor 5 isoform X1 [Rattus norvegicus]","gi|672075834|ref|XM_008770059.1|",4882,0,"PREDICTED: Rattus norvegicus EPH receptor A5 (Epha5), transcript variant X1, mRNA","P54756",1984,0,"Ephrin type-A receptor 5",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0007162|negative regulation of cell adhesion;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007275|multicellular organism development;GO:0007411|axon guidance;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0019933|cAMP-mediated signaling;GO:0021766|hippocampus development;GO:0032793|positive regulation of CREB transcription factor activity;GO:0032956|regulation of actin cytoskeleton organization;GO:0033674|positive regulation of kinase activity;GO:0043087|regulation of GTPase activity;GO:0048013|ephrin receptor signaling pathway;GO:0048666|neuron development;GO:0060997|dendritic spine morphogenesis;GO:0061178|regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:1904322|cellular response to forskolin;","GO:0005791|rough endoplasmic reticulum;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005912|adherens junction;GO:0009897|external side of plasma membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043235|receptor complex;GO:0048471|perinuclear region of cytoplasm;GO:0071944|cell periphery;","GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0005003|ephrin receptor activity;GO:0005004|GPI-linked ephrin receptor activity;GO:0005005|transmembrane-ephrin receptor activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0019838|growth factor binding;","K05106","EPHA5, EHK1, TYRO4; Eph receptor A5 [EC:2.7.10.1]"]
["ENSRNOG00000019660",28,2.355787522,2,0.128660876,18.31005344,4.194564097,{"v":1.61e-08,"d":"1.61E-08"},{"v":2.23e-08,"d":"2.23E-08"},"up","yes","Spib","protein_coding","chr1:95018947-95024780:-","gi|564328190|ref|XP_006229176.1|",1065,{"v":6e-135,"d":"6.00E-135"},"PREDICTED: transcription factor Spi-B isoform X4 [Rattus norvegicus]","gi|672036559|ref|XM_006229114.2|",2659,0,"PREDICTED: Rattus norvegicus Spi-B transcription factor (Spi-1/PU.1 related) (Spib), transcript variant X4, mRNA","Q5EBA3",398,{"v":5e-130,"d":"5.00E-130"},"Transcription factor Spi-B",".",".",".",".","pfam00178","Ets","Ets-domain.","GO:0002327|immature B cell differentiation;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0030154|cell differentiation;GO:0030225|macrophage differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09439","SPIB; transcription factor Spi-B"]
["ENSRNOG00000065742",28,2.355787522,2,0.128660876,18.31005344,4.194564097,{"v":1.61e-08,"d":"1.61E-08"},{"v":2.23e-08,"d":"2.23E-08"},"up","yes","ENSRNOG00000065742","protein_coding","chr2:231461798-231474541:-","gi|564301078|ref|XP_003753729.2|",2514,0,"PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC685116 isoform X1 [Rattus norvegicus]","gi|672016388|ref|XM_003753681.3|",1163,0,"PREDICTED: Rattus norvegicus similar to guanylate binding protein family, member 6 (LOC685116), transcript variant X1, mRNA","Q61107",702,0,"Guanylate-binding protein 4",".",".",".",".","pfam02841","GBP_C","Guanylate-binding protein, C-terminal domain. Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.",".",".",".",".","."]
["ENSRNOG00000008134",137,11.5265318,83,5.339426369,2.158758452,1.110201826,{"v":1.66E-8,"d":"1.66E-08"},{"v":2.29E-8,"d":"2.29E-08"},"up","yes","Mefv","protein_coding","chr10:11787422-11796973:+","gi|149042690|gb|EDL96327.1|",4296,0,"Mediterranean fever, isoform CRA_b [Rattus norvegicus]","gi|13928875|ref|NM_031634.1|",2012,0,"Rattus norvegicus Mediterranean fever (Mefv), mRNA","Q9JJ25",1290,0,"Pyrin",".",".",".",".","pfam02758","PYRIN","PAAD/DAPIN/Pyrin domain. This domain is predicted to contain 6 alpha helices and to have the same fold as the pfam00531 domain. This similarity may mean that this is a protein-protein interaction domain.","GO:0006954|inflammatory response;GO:0010468|regulation of gene expression;GO:0010508|positive regulation of autophagy;GO:0016567|protein ubiquitination;GO:0032496|response to lipopolysaccharide;GO:0032651|regulation of interleukin-1 beta production;GO:0032691|negative regulation of interleukin-1 beta production;GO:0032695|negative regulation of interleukin-12 production;GO:0034021|response to silicon dioxide;GO:0034341|response to interferon-gamma;GO:0045087|innate immune response;GO:0050728|negative regulation of inflammatory response;GO:0071641|negative regulation of macrophage inflammatory protein 1 alpha production;GO:1900016|negative regulation of cytokine production involved in inflammatory response;GO:1900226|negative regulation of NLRP3 inflammasome complex assembly;GO:1904270|pyroptosome complex assembly;GO:2001056|positive regulation of cysteine-type endopeptidase activity;","GO:0001726|ruffle;GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005776|autophagosome;GO:0005829|cytosol;GO:0005874|microtubule;GO:0005875|microtubule associated complex;GO:0030027|lamellipodium;GO:0031410|cytoplasmic vesicle;","GO:0003674|molecular_function;GO:0003779|actin binding;GO:0008270|zinc ion binding;GO:0042802|identical protein binding;GO:0061630|ubiquitin protein ligase activity;","K12803","MEFV; pyrin"]
["ENSRNOG00000037167",40,3.365410746,8,0.514643505,6.5393048,2.70913727,{"v":1.69e-08,"d":"1.69E-08"},{"v":2.33E-8,"d":"2.33E-08"},"up","yes","Rtp3","protein_coding","chr8:110970160-110974699:-","gi|157824049|ref|NP_001101660.1|",1754,0,"receptor-transporting protein 3 [Rattus norvegicus]","gi|157824048|ref|NM_001108190.1|",1958,0,"Rattus norvegicus receptor (chemosensory) transporter protein 3 (Rtp3), mRNA","Q5QGU6",418,{"v":1e-137,"d":"1.00E-137"},"Receptor-transporting protein 3",".",".",".",".","pfam13695","zf-3CxxC","Zinc-binding domain. This is a family with several pairs of CxxC motifs possibly representing a multiple zinc-binding region. Only one pair of cysteines is associated with a highly conserved histidine residue.","GO:0001580|detection of chemical stimulus involved in sensory perception of bitter taste;GO:0006612|protein targeting to membrane;GO:0051205|protein insertion into membrane;","GO:0005737|cytoplasm;GO:0016021|integral component of membrane;","GO:0031849|olfactory receptor binding;",".","."]
["ENSRNOG00000002161",108,9.086609014,58,3.731165415,2.435327305,1.284115682,{"v":1.86e-08,"d":"1.86E-08"},{"v":2.56e-08,"d":"2.56E-08"},"up","yes","Tlr6","protein_coding","chr14:43362164-43375685:+","gi|564383646|ref|XP_006251022.1|",4063,0,"PREDICTED: toll-like receptor 6 isoform X1 [Rattus norvegicus]","gi|672076173|ref|XM_006250960.2|",3567,0,"PREDICTED: Rattus norvegicus toll-like receptor 6 (Tlr6), transcript variant X1, mRNA","Q9EPW9",1358,0,"Toll-like receptor 6",".",".",".",".","pfam01582","TIR","TIR domain. The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.","GO:0001774|microglial cell activation;GO:0001775|cell activation;GO:0002224|toll-like receptor signaling pathway;GO:0002755|MyD88-dependent toll-like receptor signaling pathway;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0010628|positive regulation of gene expression;GO:0032493|response to bacterial lipoprotein;GO:0032717|negative regulation of interleukin-8 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0034136|negative regulation of toll-like receptor 2 signaling pathway;GO:0034150|toll-like receptor 6 signaling pathway;GO:0035666|TRIF-dependent toll-like receptor signaling pathway;GO:0042496|detection of diacyl bacterial lipopeptide;GO:0043032|positive regulation of macrophage activation;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043507|positive regulation of JUN kinase activity;GO:0045087|innate immune response;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0046209|nitric oxide metabolic process;GO:0050729|positive regulation of inflammatory response;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0071221|cellular response to bacterial lipopeptide;GO:0071726|cellular response to diacyl bacterial lipopeptide;GO:0140052|cellular response to oxidised low-density lipoprotein particle stimulus;GO:1900017|positive regulation of cytokine production involved in inflammatory response;GO:1900227|positive regulation of NLRP3 inflammasome complex assembly;GO:1903223|positive regulation of oxidative stress-induced neuron death;GO:1903428|positive regulation of reactive oxygen species biosynthetic process;GO:1904646|cellular response to amyloid-beta;","GO:0005794|Golgi apparatus;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;GO:0035355|Toll-like receptor 2-Toll-like receptor 6 protein complex;GO:0043235|receptor complex;GO:0045121|membrane raft;","GO:0003953|NAD+ nucleosidase activity;GO:0004888|transmembrane signaling receptor activity;GO:0005102|signaling receptor binding;GO:0035663|Toll-like receptor 2 binding;GO:0038023|signaling receptor activity;GO:0042498|diacyl lipopeptide binding;GO:0042802|identical protein binding;GO:0046982|protein heterodimerization activity;GO:0071723|lipopeptide binding;","K10169","TLR6, CD286; toll-like receptor 6"]
["ENSRNOG00000070502",53,4.459169238,16,1.029287011,4.33228943,2.115129629,{"v":1.92E-8,"d":"1.92E-08"},{"v":2.63e-08,"d":"2.63E-08"},"up","yes","ENSRNOG00000070502","lncRNA","chr5:8978744-8981492:-",".",".",".",".","gi|61675915|gb|AC102462.19|",369,0,"Mus musculus chromosome 1, clone RP24-327F2, complete sequence",".",".",".",".",".",".",".",".","pfam10326","7TM_GPCR_Str","Serpentine type 7TM GPCR chemoreceptor Str. Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.",".",".",".",".","."]
["ENSRNOG00000013967",134,11.274126,81,5.210765493,2.163621835,1.113448362,{"v":2.2e-08,"d":"2.20E-08"},{"v":3.01e-08,"d":"3.01E-08"},"up","yes","Blnk","protein_coding","chr1:239753648-239821113:-","gi|71043856|ref|NP_001020938.1|",2340,0,"B-cell linker protein [Rattus norvegicus]","gi|71043855|ref|NM_001025767.1|",1732,0,"Rattus norvegicus B-cell linker (Blnk), mRNA","Q4KM52",905,0,"B-cell linker protein",".",".",".",".","pfam00017","SH2","SH2 domain.","GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0008150|biological_process;GO:0010628|positive regulation of gene expression;GO:0035556|intracellular signal transduction;GO:0042113|B cell activation;GO:0050853|B cell receptor signaling pathway;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0036464|cytoplasmic ribonucleoprotein granule;","GO:0003674|molecular_function;GO:0019899|enzyme binding;GO:0019901|protein kinase binding;GO:0035591|signaling adaptor activity;GO:0042169|SH2 domain binding;GO:0043274|phospholipase binding;GO:1990782|protein tyrosine kinase binding;","K07371","BLNK; B-cell linker protein"]
["ENSRNOG00000017120",104,8.750067939,55,3.5381741,2.473046179,1.306289179,{"v":2.23e-08,"d":"2.23E-08"},{"v":3.04e-08,"d":"3.04E-08"},"up","yes","Abhd2","protein_coding","chr1:133217375-133299061:+","gi|157820401|ref|NP_001099745.1|",2235,0,"abhydrolase domain-containing protein 2 [Rattus norvegicus]","gi|74137721|dbj|AK139526.1|",2014,0,"Mus musculus 2 cells egg cDNA, RIKEN full-length enriched library, clone:B020003E02 product:abhydrolase domain containing 2, full insert sequence","Q9QXM0",863,0,"Monoacylglycerol lipase ABHD2","ECU07g0900",108,{"v":3E-24,"d":"3.00E-24"},"COG0429","pfam00561","Abhydrolase_1","alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.","GO:0007340|acrosome reaction;GO:0009611|response to wounding;GO:0030336|negative regulation of cell migration;GO:0032570|response to progesterone;GO:0043401|steroid hormone mediated signaling pathway;GO:0044255|cellular lipid metabolic process;GO:0046464|acylglycerol catabolic process;GO:0048240|sperm capacitation;GO:0051792|medium-chain fatty acid biosynthetic process;GO:0051793|medium-chain fatty acid catabolic process;","GO:0001669|acrosomal vesicle;GO:0036126|sperm flagellum;GO:0097524|sperm plasma membrane;","GO:0003707|steroid hormone receptor activity;GO:0008126|acetylesterase activity;GO:0033878|hormone-sensitive lipase activity;GO:0034338|short-chain carboxylesterase activity;GO:0042562|hormone binding;GO:0047372|acylglycerol lipase activity;","K13697","ABHD2; abhydrolase domain-containing protein 2"]
["ENSRNOG00000023881",43,3.617816552,10,0.643304382,5.623802128,2.491545835,{"v":2.32e-08,"d":"2.32E-08"},{"v":3.17e-08,"d":"3.17E-08"},"up","yes","Skap1","protein_coding","chr10:81425525-81732650:+","gi|67514574|ref|NP_775433.2|",1509,0,"src kinase-associated phosphoprotein 1 [Rattus norvegicus]","gi|241982901|gb|AC136178.3|",1314,0,"Rattus norvegicus CH230-435P16 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q4V7G1",585,0,"Src kinase-associated phosphoprotein 1",".",".",".",".","pfam00169","PH","PH domain. PH stands for pleckstrin homology.","GO:0001954|positive regulation of cell-matrix adhesion;GO:0002250|adaptive immune response;GO:0002821|positive regulation of adaptive immune response;GO:0033625|positive regulation of integrin activation;GO:0033634|positive regulation of cell-cell adhesion mediated by integrin;GO:0034116|positive regulation of heterotypic cell-cell adhesion;GO:0045785|positive regulation of cell adhesion;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050852|T cell receptor signaling pathway;GO:0072659|protein localization to plasma membrane;GO:1903039|positive regulation of leukocyte cell-cell adhesion;","GO:0001772|immunological synapse;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0032991|protein-containing complex;GO:0042101|T cell receptor complex;GO:0044853|plasma membrane raft;","GO:0005515|protein binding;GO:0019901|protein kinase binding;GO:0019903|protein phosphatase binding;GO:0042169|SH2 domain binding;GO:0044877|protein-containing complex binding;","K17699","SKAP1, SKAP55; src kinase associated phosphoprotein 1"]
["ENSRNOG00000042251",25,2.103381716,0,0.032165219,65.393048,6.031065364,{"v":2.36E-8,"d":"2.36E-08"},{"v":3.21e-08,"d":"3.21E-08"},"up","yes","AABR07030771.1","protein_coding","chr10:100083490-100115821:-","gi|392351722|ref|XP_002727887.2|",1551,0,"PREDICTED: CMRF35-like molecule 5 isoform X3 [Rattus norvegicus]","gi|564375262|ref|XM_002727841.3|",1399,0,"PREDICTED: Rattus norvegicus Cd300 molecule-like family member D (Cd300ld), transcript variant X3, mRNA","Q6SJQ5",221,{"v":6e-67,"d":"6.00E-67"},"CMRF35-like molecule 3",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000038202",51,4.290898701,15,0.964956573,4.446727264,2.152743921,{"v":2.49e-08,"d":"2.49E-08"},{"v":3.38e-08,"d":"3.38E-08"},"up","yes","Calml4","protein_coding","chr8:63323351-63335234:+","gi|148694085|gb|EDL26032.1|",895,{"v":5e-118,"d":"5.00E-118"},"calmodulin-like 4, isoform CRA_c [Mus musculus]","gi|189011706|ref|NM_001127575.1|",896,0,"Rattus norvegicus calmodulin-like 4 (Calml4), mRNA","Q91WQ9",311,{"v":5e-105,"d":"5.00E-105"},"Calmodulin-like protein 4","SPAC3A12.14",116,{"v":3e-30,"d":"3.00E-30"},"COG5126","pfam13499","EF-hand_7","EF-hand domain pair.","GO:0050790|regulation of catalytic activity;",".","GO:0005509|calcium ion binding;GO:0030234|enzyme regulator activity;","K02183","CALM; calmodulin"]
["ENSRNOG00000023122",64,5.384657193,24,1.543930516,3.487629227,1.802246674,{"v":2.78e-08,"d":"2.78E-08"},{"v":3.75e-08,"d":"3.75E-08"},"up","yes","ENSRNOG00000023122","protein_coding","chr7:109248942-109253716:-","gi|672022080|ref|XP_008774731.1|",1297,{"v":5e-173,"d":"5.00E-173"},"PREDICTED: apolipoprotein L3-like isoform X2 [Rattus norvegicus]","gi|672059735|ref|XM_006241949.2|",1538,0,"PREDICTED: Rattus norvegicus apolipoprotein L 11a (Apol11a), transcript variant X3, mRNA","O95236",144,{"v":2e-36,"d":"2.00E-36"},"Apolipoprotein L3",".",".",".",".","pfam05461","ApoL","Apolipoprotein L. Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.","GO:0006869|lipid transport;GO:0042157|lipoprotein metabolic process;","GO:0005576|extracellular region;",".","K14480","APOL; apolipoprotein L"]
["ENSRNOG00000025634",81,6.81495676,37,2.380226213,2.863155075,1.517605812,{"v":3.23e-08,"d":"3.23E-08"},{"v":4.34e-08,"d":"4.34E-08"},"up","yes","Zfhx2","protein_coding","chr15:28533156-28565128:-","gi|149274619|ref|NP_001092273.1|",7718,0,"zinc finger homeobox protein 2 [Rattus norvegicus]","gi|755548270|ref|XM_006518979.2|",7051,0,"PREDICTED: Mus musculus zinc finger homeobox 2 (Zfhx2), transcript variant X2, mRNA","Q2MHN3",2796,0,"Zinc finger homeobox protein 2","ECU06g0500",57,{"v":6e-08,"d":"6.00E-08"},"COG5576","pfam00046","Homeobox","Homeobox domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0007420|brain development;GO:0030534|adult behavior;GO:0045664|regulation of neuron differentiation;GO:0051930|regulation of sensory perception of pain;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0008270|zinc ion binding;","K09379","ZFHX2; zinc finger homeobox protein 2"]
["ENSRNOG00000032368",27,2.271652253,2,0.128660876,17.65612296,4.142096677,{"v":3.24e-08,"d":"3.24E-08"},{"v":4.35e-08,"d":"4.35E-08"},"up","yes","Tlr11","protein_coding","chr15:23545408-23549849:+","gi|408684405|ref|NP_001138251.2|",4104,0,"toll-like receptor 11 [Rattus norvegicus]","gi|408684404|ref|NM_001144779.2|",3219,0,"Rattus norvegicus toll-like receptor 11 (Tlr11), mRNA","Q6R5P0",1326,0,"Toll-like receptor 11","alr0124_1",63.2,{"v":3E-9,"d":"3.00E-09"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0002224|toll-like receptor signaling pathway;GO:0006954|inflammatory response;GO:0009617|response to bacterium;GO:0045087|innate immune response;","GO:0005887|integral component of plasma membrane;","GO:0003953|NAD+ nucleosidase activity;GO:0004888|transmembrane signaling receptor activity;GO:0038023|signaling receptor activity;","K14142","TLR11; toll-like receptor 11"]
["ENSRNOG00000055650",52,4.37503397,16,1.029287011,4.25054812,2.087648893,{"v":3.39e-08,"d":"3.39E-08"},{"v":4.55e-08,"d":"4.55E-08"},"up","yes","Pou2f2","protein_coding","chr1:80685741-80724261:-","gi|982316779|ref|XP_015297560.1|",1450,0,"PREDICTED: POU domain, class 2, transcription factor 2 isoform X11 [Macaca fascicularis]","gi|755519209|ref|XM_006539659.2|",2297,0,"PREDICTED: Mus musculus POU domain, class 2, transcription factor 2 (Pou2f2), transcript variant X14, mRNA","P09086",491,{"v":5e-157,"d":"5.00E-157"},"POU domain, class 2, transcription factor 2",".",".",".",".","pfam00157","Pou","Pou domain - N-terminal to homeobox domain.","GO:0002335|mature B cell differentiation;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0032755|positive regulation of interleukin-6 production;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048469|cell maturation;GO:0098586|cellular response to virus;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0043231|intracellular membrane-bounded organelle;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0019904|protein domain specific binding;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09364","POU2F, OTF; POU domain transcription factor, class 2"]
["ENSRNOG00000053309",112,9.423150088,63,4.052817606,2.325086151,1.217284173,{"v":3.96e-08,"d":"3.96E-08"},{"v":5.28e-08,"d":"5.28E-08"},"up","yes","Tubd1","protein_coding","chr10:71368133-71391266:+","gi|149053750|gb|EDM05567.1|",2445,0,"tubulin, delta 1 (predicted), isoform CRA_b [Rattus norvegicus]","gi|312261241|ref|NM_001199047.1|",1142,0,"Mus musculus tubulin, delta 1 (Tubd1), transcript variant 4, mRNA","Q9R1K7",896,0,"Tubulin delta chain","SPBC32F12.04",152,{"v":5e-39,"d":"5.00E-39"},"COG5023","pfam00091","Tubulin","Tubulin/FtsZ family, GTPase domain. This family includes the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division. It is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules.","GO:0030030|cell projection organization;GO:0045880|positive regulation of smoothened signaling pathway;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005814|centriole;GO:0005829|cytosol;GO:0005929|cilium;","GO:0003924|GTPase activity;","K10390","TUBD; tubulin delta"]
["ENSRNOG00000015297",31,2.608193328,4,0.257321753,10.13592244,3.341405485,{"v":4.03e-08,"d":"4.03E-08"},{"v":5.37e-08,"d":"5.37E-08"},"up","yes","RGD1561662","protein_coding","chr9:13525395-13561585:-","gi|564367294|ref|XP_006244562.1|",4149,0,"PREDICTED: uncharacterized protein C6orf132 homolog isoform X2 [Rattus norvegicus]","gi|672064477|ref|XM_006244500.2|",4071,0,"PREDICTED: Rattus norvegicus similar to AI661453 protein (RGD1561662), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam03154","Atrophin-1","Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.",".",".",".",".","."]
["ENSRNOG00000034174",31,2.608193328,4,0.257321753,10.13592244,3.341405485,{"v":4.03e-08,"d":"4.03E-08"},{"v":5.37e-08,"d":"5.37E-08"},"up","yes","Bpifb4","protein_coding","chr3:142400976-142448044:+","gi|306482632|ref|NP_001102679.2|",2530,0,"BPI fold-containing family B member 4 precursor [Rattus norvegicus]","gi|306482631|ref|NM_001109209.2|",1932,0,"Rattus norvegicus BPI fold containing family B, member 4 (Bpifb4), mRNA","Q05704",984,0,"BPI fold-containing family B member 4",".",".",".",".","pfam01273","LBP_BPI_CETP","LBP / BPI / CETP family, N-terminal domain. The N and C terminal domains of the LBP/BPI/CETP family are structurally similar.",".","GO:0005576|extracellular region;GO:0005737|cytoplasm;","GO:0008289|lipid binding;","K25376","BPIFB, LPLUNC; BPI fold-containing family B"]
["ENSRNOG00000024793",59,4.96398085,21,1.350939202,3.674466507,1.877534801,{"v":4.15e-08,"d":"4.15E-08"},{"v":5.53e-08,"d":"5.53E-08"},"up","yes","Kctd21","protein_coding","chr1:151650104-151667645:+","gi|625217933|ref|XP_007649206.1|",1426,0,"PREDICTED: BTB/POZ domain-containing protein KCTD21 [Cricetulus griseus]","gi|672038043|ref|XM_006229781.2|",3029,0,"PREDICTED: Rattus norvegicus potassium channel tetramerization domain containing 21 (Kctd21), transcript variant X1, mRNA","Q4G0X4",534,0,"BTB/POZ domain-containing protein KCTD21",".",".",".",".","pfam02214","BTB_2","BTB/POZ domain. In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.",".",".",".",".","."]
["ENSRNOG00000070677",24,2.019246448,0,0.032165219,62.77732608,5.972171675,{"v":4.44e-08,"d":"4.44E-08"},{"v":5.9e-08,"d":"5.90E-08"},"up","yes","ENSRNOG00000070677","protein_coding","chr12:18516156-18525346:+","gi|564378700|ref|XP_006249121.1|",1086,{"v":2E-140,"d":"2.00E-140"},"PREDICTED: paired immunoglobulin-like type 2 receptor beta isoform X1 [Rattus norvegicus]","gi|672072515|ref|XR_595294.1|",1193,0,"PREDICTED: Rattus norvegicus similar to paired immunoglobin-like type 2 receptor beta (LOC681341), transcript variant X7, misc_RNA","Q2YFS2",308,{"v":9e-98,"d":"9.00E-98"},"Paired immunoglobulin-like type 2 receptor beta",".",".",".",".","pfam14329","DUF4386","Domain of unknown function (DUF4386). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 214 and 245 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000043300",71,5.973604074,30,1.929913146,3.095270939,1.630065699,{"v":4.98e-08,"d":"4.98E-08"},{"v":6.59e-08,"d":"6.59E-08"},"up","yes","Enho","protein_coding","chr5:56800980-56802777:-","gi|26341256|dbj|BAC34290.1|",391,{"v":5e-43,"d":"5.00E-43"},"unnamed protein product [Mus musculus]","gi|537361057|ref|NM_001282336.1|",952,0,"Rattus norvegicus energy homeostasis associated (Enho), mRNA","Q8K1D8",65.9,{"v":2E-12,"d":"2.00E-12"},"Adropin",".",".",".",".","pfam15548","DUF4655","Domain of unknown function (DUF4655). This family of proteins is found in eukaryotes. Proteins in this family are typically between 533 and 570 amino acids in length.","GO:0007165|signal transduction;GO:0045747|positive regulation of Notch signaling pathway;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0005179|hormone activity;","K25411","ENHO; adropin"]
["ENSRNOG00000047367",90,7.572174178,45,2.894869718,2.61572192,1.387209175,{"v":5.08e-08,"d":"5.08E-08"},{"v":6.72e-08,"d":"6.72E-08"},"up","yes","Card14","protein_coding","chr10:104566424-104601905:+","gi|564313819|ref|XP_006221025.1|",4658,0,"PREDICTED: caspase recruitment domain-containing protein 14 [Rattus norvegicus]","gi|568971961|ref|XM_006532373.1|",2855,0,"PREDICTED: Mus musculus caspase recruitment domain family, member 14 (Card14), transcript variant X8, mRNA","Q99KF0",1735,0,"Caspase recruitment domain-containing protein 14",".",".",".",".","pfam00619","CARD","Caspase recruitment domain. Motif contained in proteins involved in apoptotic signaling. Predicted to possess a DEATH (pfam00531) domain-like fold.","GO:0001934|positive regulation of protein phosphorylation;GO:0033209|tumor necrosis factor-mediated signaling pathway;GO:0043066|negative regulation of apoptotic process;GO:0051092|positive regulation of NF-kappaB transcription factor activity;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016235|aggresome;","GO:0050700|CARD domain binding;","K20913","CARD14; caspase recruitment domain-containing protein 14"]
["ENSRNOG00000014226",40,3.365410746,9,0.578973944,5.812715378,2.539212268,{"v":5.17E-8,"d":"5.17E-08"},{"v":6.82e-08,"d":"6.82E-08"},"up","yes","Plch2","protein_coding","chr5:165544200-165602356:-","gi|568931391|ref|XP_006538999.1|",7036,0,"PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X2 [Mus musculus]","gi|294862234|ref|NM_175556.4|",4394,0,"Mus musculus phospholipase C, eta 2 (Plch2), transcript variant 1, mRNA","A2AP18",1886,0,"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2",".",".",".",".","pfam00388","PI-PLC-X","Phosphatidylinositol-specific phospholipase C, X domain. This associates with pfam00387 to form a single structural unit.","GO:0016042|lipid catabolic process;GO:0046488|phosphatidylinositol metabolic process;GO:0048015|phosphatidylinositol-mediated signaling;","GO:0005886|plasma membrane;","GO:0004435|phosphatidylinositol phospholipase C activity;GO:0004629|phospholipase C activity;GO:0005509|calcium ion binding;","K19006","PLCH; phosphatidylinositol phospholipase C, eta [EC:3.1.4.11]"]
["ENSRNOG00000004589",109,9.170744282,61,3.924156729,2.336997453,1.224656162,{"v":5.19e-08,"d":"5.19E-08"},{"v":6.86e-08,"d":"6.86E-08"},"up","yes","Galnt16","protein_coding","chr6:100170306-100250705:+","gi|50510795|dbj|BAD32383.1|",2890,0,"mKIAA1130 protein [Mus musculus]","gi|291167741|ref|NM_001100863.1|",3846,0,"Rattus norvegicus polypeptide N-acetylgalactosaminyltransferase 16 (Galnt16), mRNA","Q9JJ61",1089,0,"Polypeptide N-acetylgalactosaminyltransferase 16",".",".",".",".","pfam00535","Glycos_transf_2","Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.","GO:0018242|protein O-linked glycosylation via serine;GO:0018243|protein O-linked glycosylation via threonine;","GO:0000139|Golgi membrane;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;","GO:0004653|polypeptide N-acetylgalactosaminyltransferase activity;GO:0030246|carbohydrate binding;GO:0046872|metal ion binding;","K00710","GALNT; polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41]"]
["ENSRNOG00000011716",48,4.038492895,14,0.900626135,4.48409472,2.164816753,{"v":5.75e-08,"d":"5.75E-08"},{"v":7.56e-08,"d":"7.56E-08"},"up","yes","Degs2","protein_coding","chr6:127596071-127613293:-","gi|62945270|ref|NP_001017457.1|",1660,0,"sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 [Rattus norvegicus]","gi|83649765|ref|NM_001017457.2|",1282,0,"Rattus norvegicus delta(4)-desaturase, sphingolipid 2 (Degs2), mRNA","Q564G3",642,0,"Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2",".",".",".",".","pfam00487","FA_desaturase","Fatty acid desaturase.","GO:0006667|sphinganine metabolic process;GO:0030148|sphingolipid biosynthetic process;GO:0046513|ceramide biosynthetic process;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0000170|sphingosine hydroxylase activity;GO:0042284|sphingolipid delta-4 desaturase activity;","K04712","DEGS; sphingolipid 4-desaturase/C4-monooxygenase [EC:1.14.19.17 1.14.18.5]"]
["ENSRNOG00000005807",68,5.721198268,28,1.801252269,3.17623376,1.667317094,{"v":5.88e-08,"d":"5.88E-08"},{"v":7.72e-08,"d":"7.72E-08"},"up","yes","Ptpn7","protein_coding","chr13:46571712-46583308:+","gi|21728414|ref|NP_663716.1|",1680,0,"tyrosine-protein phosphatase non-receptor type 7 [Rattus norvegicus]","gi|672074008|ref|XM_006249821.2|",1806,0,"PREDICTED: Rattus norvegicus protein tyrosine phosphatase, non-receptor type 7 (Ptpn7), transcript variant X2, mRNA","P49445",651,0,"Tyrosine-protein phosphatase non-receptor type 7","SPAC11E3.09",120,{"v":1e-28,"d":"1.00E-28"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0006470|protein dephosphorylation;GO:0035335|peptidyl-tyrosine dephosphorylation;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0009898|cytoplasmic side of plasma membrane;GO:0015630|microtubule cytoskeleton;GO:0072686|mitotic spindle;","GO:0004725|protein tyrosine phosphatase activity;","K18019","PTPN7; tyrosine-protein phosphatase non-receptor type 7 [EC:3.1.3.48]"]
["ENSRNOG00000039759",38,3.197140209,8,0.514643505,6.21233956,2.635136688,{"v":6.05e-08,"d":"6.05E-08"},{"v":7.94e-08,"d":"7.94E-08"},"up","yes","ENSRNOG00000039759","protein_coding","chrX:9104565-9148601:-","gi|67972437|ref|NP_001020096.1|",1970,0,"probable G-protein coupled receptor 34 [Rattus norvegicus]","gi|672086955|ref|XM_006256676.2|",1977,0,"PREDICTED: Rattus norvegicus G protein-coupled receptor 34 (Gpr34), transcript variant X2, mRNA","Q9R1K6",728,0,"Probable G-protein coupled receptor 34",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0035589|G protein-coupled purinergic nucleotide receptor signaling pathway;","GO:0016021|integral component of membrane;","GO:0045028|G protein-coupled purinergic nucleotide receptor activity;","K08383","GPR34; G protein-coupled receptor 34"]
["ENSRNOG00000016980",36,3.028869671,7,0.450313067,6.72614208,2.749779254,{"v":6.89e-08,"d":"6.89E-08"},{"v":8.99e-08,"d":"8.99E-08"},"up","yes","Qprt","protein_coding","chr1:181718190-181733486:-","gi|564330955|ref|XP_006230308.1|",1744,0,"PREDICTED: nicotinate-nucleotide pyrophosphorylase [carboxylating] isoform X1 [Rattus norvegicus]","gi|672038422|ref|XM_006230246.2|",1361,0,"PREDICTED: Rattus norvegicus quinolinate phosphoribosyltransferase (Qprt), transcript variant X1, mRNA","Q5I0M2",533,0,"Nicotinate-nucleotide pyrophosphorylase [carboxylating]","YFR047c",247,{"v":6e-76,"d":"6.00E-76"},"COG0157","pfam01729","QRPTase_C","Quinolinate phosphoribosyl transferase, C-terminal domain. Quinolinate phosphoribosyl transferase (QPRTase) or nicotinate-nucleotide pyrophosphorylase EC:2.4.2.19 is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to give rise to nicotinic acid mononucleotide (NaMN), pyrophosphate and carbon dioxide. The QA substrate is bound between the C-terminal domain of one subunit, and the N-terminal domain of the other. The C-terminal domain has a 7 beta-stranded TIM barrel-like fold.","GO:0009435|NAD biosynthetic process;GO:0034213|quinolinate catabolic process;GO:0046874|quinolinate metabolic process;","GO:0005737|cytoplasm;GO:1902494|catalytic complex;","GO:0004514|nicotinate-nucleotide diphosphorylase (carboxylating) activity;GO:0042802|identical protein binding;","K00767","nadC, QPRT; nicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:2.4.2.19]"]
["ENSRNOG00000027855",28,2.355787522,3,0.192991315,12.20670229,3.609601596,{"v":7.45e-08,"d":"7.45E-08"},{"v":9.69e-08,"d":"9.69E-08"},"up","yes","ENSRNOG00000027855","protein_coding","chr1:69616601-69660558:-","gi|625288029|ref|XP_007635741.1|",2046,0,"PREDICTED: LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily B member 3 isoform X2 [Cricetulus griseus]","gi|17105353|ref|NM_057199.1|",1042,0,"Rattus norvegicus natural cytotoxicity triggering receptor 1 (Ncr1), mRNA","Q9Z0H5",654,0,"Natural cytotoxicity triggering receptor 1",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0002446|neutrophil mediated immunity;GO:0033031|positive regulation of neutrophil apoptotic process;GO:0035457|cellular response to interferon-alpha;GO:0038093|Fc receptor signaling pathway;GO:0042119|neutrophil activation;GO:0071222|cellular response to lipopolysaccharide;GO:0071346|cellular response to interferon-gamma;GO:0071354|cellular response to interleukin-6;GO:0071356|cellular response to tumor necrosis factor;GO:0097011|cellular response to granulocyte macrophage colony-stimulating factor stimulus;GO:1903209|positive regulation of oxidative stress-induced cell death;","GO:0005886|plasma membrane;","GO:0019766|IgA receptor activity;GO:0019862|IgA binding;","K06513","FCAR, CD89; CD89 antigen"]
["ENSRNOG00000020332",91,7.656309447,47,3.023530595,2.532241433,1.340414963,{"v":9.46E-8,"d":"9.46E-08"},{"v":1.22e-07,"d":"1.22E-07"},"up","yes","Tnnt3","protein_coding","chr1:197652431-197669535:+","gi|149061720|gb|EDM12143.1|",662,{"v":1e-111,"d":"1.00E-111"},"troponin T3, skeletal, fast, isoform CRA_g, partial [Rattus norvegicus]","gi|33354295|gb|AC098563.6|",1277,0,"Rattus norvegicus 1 BAC CH230-123A15 (Children's Hospital Oakland Research Institute) complete sequence","P02641",269,{"v":5e-81,"d":"5.00E-81"},"Troponin T, fast skeletal muscle",".",".",".",".","pfam00992","Troponin","Troponin. Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). this Pfam contains members of the TnT subunit. Troponin is a complex of three proteins, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). The troponin complex regulates Ca++ induced muscle contraction. This family includes troponin T and troponin I. Troponin I binds to actin and troponin T binds to tropomyosin.","GO:0003009|skeletal muscle contraction;GO:0006936|muscle contraction;GO:0006937|regulation of muscle contraction;GO:0006942|regulation of striated muscle contraction;GO:0043462|regulation of ATPase activity;GO:0045214|sarcomere organization;GO:1903612|positive regulation of calcium-dependent ATPase activity;","GO:0005861|troponin complex;","GO:0003779|actin binding;GO:0005523|tropomyosin binding;GO:0030172|troponin C binding;GO:0031013|troponin I binding;GO:0031014|troponin T binding;GO:0048306|calcium-dependent protein binding;","K12046","TNNT3; troponin T, fast skeletal muscle"]
["ENSRNOG00000009260",98,8.245256327,53,3.409513224,2.418308945,1.273998564,{"v":1.01E-7,"d":"1.01E-07"},{"v":1.3E-7,"d":"1.30E-07"},"up","yes","Cnr2","protein_coding","chr5:148125604-148151548:+","gi|255918134|ref|NP_001157614.1|",1833,0,"cannabinoid receptor 2 isoform 1 [Rattus norvegicus]","gi|694872628|ref|NM_001164143.3|",3300,0,"Rattus norvegicus cannabinoid receptor 2 (Cnr2), transcript variant 1, mRNA","Q9QZN9",710,0,"Cannabinoid receptor 2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001975|response to amphetamine;GO:0006954|inflammatory response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0019222|regulation of metabolic process;GO:0019233|sensory perception of pain;GO:0030595|leukocyte chemotaxis;GO:0032229|negative regulation of synaptic transmission, GABAergic;GO:0032496|response to lipopolysaccharide;GO:0033004|negative regulation of mast cell activation;GO:0038171|cannabinoid signaling pathway;GO:0045759|negative regulation of action potential;GO:0050728|negative regulation of inflammatory response;GO:0051001|negative regulation of nitric-oxide synthase activity;","GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043204|perikaryon;","GO:0004930|G protein-coupled receptor activity;GO:0004949|cannabinoid receptor activity;","K04278","CNR2; cannabinoid receptor 2"]
["ENSRNOG00000009694",98,8.245256327,53,3.409513224,2.418308945,1.273998564,{"v":1.01E-7,"d":"1.01E-07"},{"v":1.3E-7,"d":"1.30E-07"},"up","yes","Bmp4","protein_coding","chr15:19618542-19623306:-","gi|148688764|gb|EDL20711.1|",2156,0,"bone morphogenetic protein 4, isoform CRA_b, partial [Mus musculus]","gi|672077434|ref|XM_006251746.2|",2401,0,"PREDICTED: Rattus norvegicus bone morphogenetic protein 4 (Bmp4), transcript variant X1, mRNA","P21275",777,0,"Bone morphogenetic protein 4",".",".",".",".","pfam00688","TGFb_propeptide","TGF-beta propeptide. This propeptide is known as latency associated peptide (LAP) in TGF-beta. LAP is a homodimer which is disulfide linked to TGF-beta binding protein.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001501|skeletal system development;GO:0001525|angiogenesis;GO:0001541|ovarian follicle development;GO:0001568|blood vessel development;GO:0001649|osteoblast differentiation;GO:0001656|metanephros development;GO:0001657|ureteric bud development;GO:0001658|branching involved in ureteric bud morphogenesis;GO:0001707|mesoderm formation;GO:0001759|organ induction;GO:0001822|kidney development;GO:0001823|mesonephros development;GO:0001843|neural tube closure;GO:0001934|positive regulation of protein phosphorylation;GO:0001938|positive regulation of endothelial cell proliferation;GO:0001944|vasculature development;GO:0001958|endochondral ossification;GO:0002043|blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:0002062|chondrocyte differentiation;GO:0002244|hematopoietic progenitor cell differentiation;GO:0002320|lymphoid progenitor cell differentiation;GO:0003014|renal system process;GO:0003130|BMP signaling pathway involved in heart induction;GO:0003139|secondary heart field specification;GO:0003148|outflow tract septum morphogenesis;GO:0003149|membranous septum morphogenesis;GO:0003151|outflow tract morphogenesis;GO:0003180|aortic valve morphogenesis;GO:0003184|pulmonary valve morphogenesis;GO:0003197|endocardial cushion development;GO:0003323|type B pancreatic cell development;GO:0003337|mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0007182|common-partner SMAD protein phosphorylation;GO:0007281|germ cell development;GO:0007420|brain development;GO:0007492|endoderm development;GO:0007498|mesoderm development;GO:0007500|mesodermal cell fate determination;GO:0007507|heart development;GO:0008283|cell proliferation;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0009612|response to mechanical stimulus;GO:0009791|post-embryonic development;GO:0009888|tissue development;GO:0009948|anterior/posterior axis specification;GO:0010159|specification of animal organ position;GO:0010453|regulation of cell fate commitment;GO:0010468|regulation of gene expression;GO:0010524|positive regulation of calcium ion transport into cytosol;GO:0010595|positive regulation of endothelial cell migration;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010718|positive regulation of epithelial to mesenchymal transition;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0010942|positive regulation of cell death;GO:0010976|positive regulation of neuron projection development;GO:0014070|response to organic cyclic compound;GO:0021537|telencephalon development;GO:0021904|dorsal/ventral neural tube patterning;GO:0021978|telencephalon regionalization;GO:0021983|pituitary gland development;GO:0030218|erythrocyte differentiation;GO:0030224|monocyte differentiation;GO:0030225|macrophage differentiation;GO:0030324|lung development;GO:0030326|embryonic limb morphogenesis;GO:0030335|positive regulation of cell migration;GO:0030501|positive regulation of bone mineralization;GO:0030509|BMP signaling pathway;GO:0030513|positive regulation of BMP signaling pathway;GO:0030900|forebrain development;GO:0032092|positive regulation of protein binding;GO:0032331|negative regulation of chondrocyte differentiation;GO:0032355|response to estradiol;GO:0032526|response to retinoic acid;GO:0032967|positive regulation of collagen biosynthetic process;GO:0033085|negative regulation of T cell differentiation in thymus;GO:0033088|negative regulation of immature T cell proliferation in thymus;GO:0033574|response to testosterone;GO:0034504|protein localization to nucleus;GO:0034599|cellular response to oxidative stress;GO:0035116|embryonic hindlimb morphogenesis;GO:0035990|tendon cell differentiation;GO:0035993|deltoid tuberosity development;GO:0042060|wound healing;GO:0042306|regulation of protein import into nucleus;GO:0042326|negative regulation of phosphorylation;GO:0042475|odontogenesis of dentin-containing tooth;GO:0042476|odontogenesis;GO:0042487|regulation of odontogenesis of dentin-containing tooth;GO:0042733|embryonic digit morphogenesis;GO:0043010|camera-type eye development;GO:0043065|positive regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0043401|steroid hormone mediated signaling pathway;GO:0043407|negative regulation of MAP kinase activity;GO:0043410|positive regulation of MAPK cascade;GO:0043587|tongue morphogenesis;GO:0045165|cell fate commitment;GO:0045595|regulation of cell differentiation;GO:0045597|positive regulation of cell differentiation;GO:0045603|positive regulation of endothelial cell differentiation;GO:0045606|positive regulation of epidermal cell differentiation;GO:0045662|negative regulation of myoblast differentiation;GO:0045666|positive regulation of neuron differentiation;GO:0045669|positive regulation of osteoblast differentiation;GO:0045778|positive regulation of ossification;GO:0045786|negative regulation of cell cycle;GO:0045839|negative regulation of mitotic nuclear division;GO:0045843|negative regulation of striated muscle tissue development;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048286|lung alveolus development;GO:0048333|mesodermal cell differentiation;GO:0048392|intermediate mesodermal cell differentiation;GO:0048593|camera-type eye morphogenesis;GO:0048598|embryonic morphogenesis;GO:0048646|anatomical structure formation involved in morphogenesis;GO:0048660|regulation of smooth muscle cell proliferation;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0048663|neuron fate commitment;GO:0048701|embryonic cranial skeleton morphogenesis;GO:0048704|embryonic skeletal system morphogenesis;GO:0048706|embryonic skeletal system development;GO:0048715|negative regulation of oligodendrocyte differentiation;GO:0048745|smooth muscle tissue development;GO:0048754|branching morphogenesis of an epithelial tube;GO:0050679|positive regulation of epithelial cell proliferation;GO:0050680|negative regulation of epithelial cell proliferation;GO:0050918|positive chemotaxis;GO:0051145|smooth muscle cell differentiation;GO:0051150|regulation of smooth muscle cell differentiation;GO:0051384|response to glucocorticoid;GO:0055007|cardiac muscle cell differentiation;GO:0055020|positive regulation of cardiac muscle fiber development;GO:0060033|anatomical structure regression;GO:0060041|retina development in camera-type eye;GO:0060113|inner ear receptor cell differentiation;GO:0060197|cloacal septation;GO:0060235|lens induction in camera-type eye;GO:0060272|embryonic skeletal joint morphogenesis;GO:0060348|bone development;GO:0060363|cranial suture morphogenesis;GO:0060391|positive regulation of SMAD protein signal transduction;GO:0060393|regulation of pathway-restricted SMAD protein phosphorylation;GO:0060395|SMAD protein signal transduction;GO:0060425|lung morphogenesis;GO:0060429|epithelium development;GO:0060433|bronchus development;GO:0060438|trachea development;GO:0060440|trachea formation;GO:0060441|epithelial tube branching involved in lung morphogenesis;GO:0060442|branching involved in prostate gland morphogenesis;GO:0060449|bud elongation involved in lung branching;GO:0060462|lung lobe development;GO:0060502|epithelial cell proliferation involved in lung morphogenesis;GO:0060503|bud dilation involved in lung branching;GO:0060512|prostate gland morphogenesis;GO:0060548|negative regulation of cell death;GO:0060592|mammary gland formation;GO:0060684|epithelial-mesenchymal cell signaling;GO:0060686|negative regulation of prostatic bud formation;GO:0060687|regulation of branching involved in prostate gland morphogenesis;GO:0060688|regulation of morphogenesis of a branching structure;GO:0060976|coronary vasculature development;GO:0061035|regulation of cartilage development;GO:0061036|positive regulation of cartilage development;GO:0061047|positive regulation of branching involved in lung morphogenesis;GO:0061149|BMP signaling pathway involved in ureter morphogenesis;GO:0061151|BMP signaling pathway involved in renal system segmentation;GO:0061155|pulmonary artery endothelial tube morphogenesis;GO:0061312|BMP signaling pathway involved in heart development;GO:0061626|pharyngeal arch artery morphogenesis;GO:0070244|negative regulation of thymocyte apoptotic process;GO:0070368|positive regulation of hepatocyte differentiation;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071260|cellular response to mechanical stimulus;GO:0071363|cellular response to growth factor stimulus;GO:0071549|cellular response to dexamethasone stimulus;GO:0071731|response to nitric oxide;GO:0071773|cellular response to BMP stimulus;GO:0071893|BMP signaling pathway involved in nephric duct formation;GO:0072015|glomerular visceral epithelial cell development;GO:0072097|negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway;GO:0072101|specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway;GO:0072104|glomerular capillary formation;GO:0072125|negative regulation of glomerular mesangial cell proliferation;GO:0072138|mesenchymal cell proliferation involved in ureteric bud development;GO:0072161|mesenchymal cell differentiation involved in kidney development;GO:0072192|ureter epithelial cell differentiation;GO:0072193|ureter smooth muscle cell differentiation;GO:0072198|mesenchymal cell proliferation involved in ureter development;GO:0072200|negative regulation of mesenchymal cell proliferation involved in ureter development;GO:0072205|metanephric collecting duct development;GO:0090184|positive regulation of kidney development;GO:0090190|positive regulation of branching involved in ureteric bud morphogenesis;GO:0090191|negative regulation of branching involved in ureteric bud morphogenesis;GO:0090194|negative regulation of glomerulus development;GO:0097067|cellular response to thyroid hormone stimulus;GO:1900745|positive regulation of p38MAPK cascade;GO:1901341|positive regulation of store-operated calcium channel activity;GO:1901964|positive regulation of cell proliferation involved in outflow tract morphogenesis;GO:1902462|positive regulation of mesenchymal stem cell proliferation;GO:1902894|negative regulation of pri-miRNA transcription by RNA polymerase II;GO:1902895|positive regulation of pri-miRNA transcription by RNA polymerase II;GO:1903800|positive regulation of production of miRNAs involved in gene silencing by miRNA;GO:1905312|positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis;GO:2000005|negative regulation of metanephric S-shaped body morphogenesis;GO:2000007|negative regulation of metanephric comma-shaped body morphogenesis;GO:2000137|negative regulation of cell proliferation involved in heart morphogenesis;GO:2000353|positive regulation of endothelial cell apoptotic process;GO:2001012|mesenchymal cell differentiation involved in renal system development;GO:2001237|negative regulation of extrinsic apoptotic signaling pathway;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0031982|vesicle;","GO:0005125|cytokine activity;GO:0008083|growth factor activity;GO:0008201|heparin binding;GO:0039706|co-receptor binding;GO:0042056|chemoattractant activity;GO:0042802|identical protein binding;GO:0070700|BMP receptor binding;","K04662","BMP4; bone morphogenetic protein 4"]
["ENSRNOG00000007310",53,4.459169238,18,1.157947887,3.850923938,1.945204628,{"v":1.02E-7,"d":"1.02E-07"},{"v":1.32e-07,"d":"1.32E-07"},"up","yes","Klrb1a","protein_coding","chr4:161890577-161961675:-","gi|148539924|ref|NP_775414.2|",1057,{"v":5e-141,"d":"5.00E-141"},"killer cell lectin-like receptor subfamily B member 1B [Rattus norvegicus]","gi|1354767|gb|U56936.1|RNU56936",1089,0,"Rattus norvegicus NK lymphocyte receptor (NKR-P1B) mRNA, complete cds","A4KWA1",411,{"v":2e-142,"d":"2.00E-142"},"Killer cell lectin-like receptor subfamily B member 1B allele A",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type",".","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0030246|carbohydrate binding;","K06543","KLRB, CD161; killer cell lectin-like receptor subfamily B"]
["ENSRNOG00000024657",77,6.478415686,36,2.315895775,2.797369276,1.484070714,{"v":1.15E-7,"d":"1.15E-07"},{"v":1.47e-07,"d":"1.47E-07"},"up","yes","Mfsd4a","protein_coding","chr13:43469488-43510467:-","gi|564380547|ref|XP_006249853.1|",2589,0,"PREDICTED: major facilitator superfamily domain-containing protein 4 isoform X1 [Rattus norvegicus]","gi|672073824|ref|XM_006249791.2|",3742,0,"PREDICTED: Rattus norvegicus major facilitator superfamily domain containing 4 (Mfsd4), transcript variant X1, mRNA","Q6PDC8",961,0,"Major facilitator superfamily domain-containing protein 4A",".",".",".",".","pfam07690","MFS_1","Major Facilitator Superfamily.","GO:1904659|glucose transmembrane transport;","GO:0016021|integral component of membrane;","GO:0005355|glucose transmembrane transporter activity;",".","."]
["ENSRNOG00000030763",42,3.533681283,11,0.70763482,4.993650938,2.320094979,{"v":1.19e-07,"d":"1.19E-07"},{"v":1.52e-07,"d":"1.52E-07"},"up","yes","Dpp4","protein_coding","chr3:46962243-47043901:-","gi|149022111|gb|EDL79005.1|",3673,0,"dipeptidylpeptidase 4, isoform CRA_a [Rattus norvegicus]","gi|6978772|ref|NM_012789.1|",4361,0,"Rattus norvegicus dipeptidylpeptidase 4 (Dpp4), mRNA","P14740",1410,0,"Dipeptidyl peptidase 4","SPACUNK4.08",306,{"v":1e-86,"d":"1.00E-86"},"COG1506","pfam00930","DPPIV_N","Dipeptidyl peptidase IV (DPP IV) N-terminal region. This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.","GO:0001662|behavioral fear response;GO:0001666|response to hypoxia;GO:0002337|B-1a B cell differentiation;GO:0002709|regulation of T cell mediated immunity;GO:0002717|positive regulation of natural killer cell mediated immunity;GO:0006508|proteolysis;GO:0007155|cell adhesion;GO:0008284|positive regulation of cell proliferation;GO:0010716|negative regulation of extracellular matrix disassembly;GO:0031295|T cell costimulation;GO:0033632|regulation of cell-cell adhesion mediated by integrin;GO:0035641|locomotory exploration behavior;GO:0036343|psychomotor behavior;GO:0042110|T cell activation;GO:0043542|endothelial cell migration;GO:0046718|viral entry into host cell;GO:0050919|negative chemotaxis;GO:0051234|establishment of localization;GO:0090024|negative regulation of neutrophil chemotaxis;","GO:0005576|extracellular region;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0030027|lamellipodium;GO:0030054|cell junction;GO:0030139|endocytic vesicle;GO:0031258|lamellipodium membrane;GO:0045121|membrane raft;GO:0046581|intercellular canaliculus;","GO:0001618|virus receptor activity;GO:0002020|protease binding;GO:0004177|aminopeptidase activity;GO:0004252|serine-type endopeptidase activity;GO:0005102|signaling receptor binding;GO:0005518|collagen binding;GO:0008236|serine-type peptidase activity;GO:0008239|dipeptidyl-peptidase activity;GO:0042277|peptide binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0045499|chemorepellent activity;","K01278","DPP4, CD26; dipeptidyl-peptidase 4 [EC:3.4.14.5]"]
["ENSRNOG00000014227",25,2.103381716,2,0.128660876,16.348262,4.031065364,{"v":1.31E-7,"d":"1.31E-07"},{"v":1.67E-7,"d":"1.67E-07"},"up","yes","Mrgprx3","protein_coding","chr1:97721436-97746900:-","gi|59709471|ref|NP_665730.2|",1457,0,"mas-related G-protein coupled receptor member A [Rattus norvegicus]","gi|59709470|ref|NM_145787.2|",1285,0,"Rattus norvegicus MAS related GPR family member X3 (Mrgprx3), mRNA","Q7TN49",513,{"v":2E-180,"d":"2.00E-180"},"Mas-related G-protein coupled receptor member A",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0007218|neuropeptide signaling pathway;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0008188|neuropeptide receptor activity;","K08396","MRGPRX; Mas-related G protein-coupled receptor member X"]
["ENSRNOG00000070389",51,4.290898701,17,1.093617449,3.92358288,1.972171675,{"v":1.37E-7,"d":"1.37E-07"},{"v":1.75e-07,"d":"1.75E-07"},"up","yes","ENSRNOG00000070389","lncRNA","chr11:3692631-3693841:-",".",".",".",".","gi|755555071|ref|XM_006523099.2|",527,0,"PREDICTED: Mus musculus vestigial like 3 (Drosophila) (Vgll3), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam10325","7TM_GPCR_Srz","Serpentine type 7TM GPCR chemoreceptor Srz. Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srz is a solo families amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srz appear to be under strong adaptive evolutionary pressure.",".",".",".",".","."]
["ENSRNOG00000000478",33,2.776463865,6,0.385982629,7.19323528,2.846640793,{"v":1.46e-07,"d":"1.46E-07"},{"v":1.86E-7,"d":"1.86E-07"},"up","yes","ENSRNOG00000000478","protein_coding","chr20:4981263-4981668:-","gi|293356975|ref|XP_002729038.1|",311,{"v":2E-35,"d":"2.00E-35"},"PREDICTED: protein kish-A [Rattus norvegicus]","gi|298891975|emb|FQ220821.1|",193,{"v":3e-95,"d":"3.00E-95"},"Rattus norvegicus TL0ADA41YJ03 mRNA sequence","Q9CR64",123,{"v":1e-36,"d":"1.00E-36"},"Protein kish-A",".",".",".",".","pfam06842","DUF1242","Protein of unknown function (DUF1242). This family consists of a number of eukaryotic proteins of around 72 residues in length. The function of this family is unknown.",".",".",".",".","."]
["ENSRNOG00000038286",33,2.776463865,6,0.385982629,7.19323528,2.846640793,{"v":1.46e-07,"d":"1.46E-07"},{"v":1.86E-7,"d":"1.86E-07"},"up","yes","Slamf6","protein_coding","chr13:84383742-84405300:+","gi|300794200|ref|NP_001178861.1|",1761,0,"SLAM family member 6 [Rattus norvegicus]","gi|300794199|ref|NM_001191932.1|",1635,0,"Rattus norvegicus SLAM family member 6 (Slamf6), mRNA","Q9ET39",441,{"v":5e-149,"d":"5.00E-149"},"SLAM family member 6",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0001779|natural killer cell differentiation;GO:0001787|natural killer cell proliferation;GO:0032729|positive regulation of interferon-gamma production;GO:0032740|positive regulation of interleukin-17 production;GO:0042110|T cell activation;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;GO:0072540|T-helper 17 cell lineage commitment;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;",".","K16852","SLAMF6, CD352; SLAM family member 6"]
["ENSRNOG00000014953",40,3.365410746,10,0.643304382,5.23144384,2.387209175,{"v":1.47e-07,"d":"1.47E-07"},{"v":1.87e-07,"d":"1.87E-07"},"up","yes","Fbxo39","protein_coding","chr10:56932297-56934906:+","gi|537143087|gb|ERE68820.1|",2410,0,"F-box only protein 39 [Cricetulus griseus]","gi|672067930|ref|XM_006246729.2|",1591,0,"PREDICTED: Rattus norvegicus F-box protein 39 (Fbxo39), transcript variant X2, mRNA","Q66H10",919,0,"F-box only protein 39",".",".",".",".","pfam12937","F-box-like","F-box-like. This is an F-box-like family.","GO:0031146|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;","GO:0019005|SCF ubiquitin ligase complex;",".","K10314","FBXO39; F-box protein 39"]
["ENSRNOG00000033906",91,7.656309447,48,3.087861033,2.479486403,1.310041314,{"v":1.58e-07,"d":"1.58E-07"},{"v":2e-07,"d":"2.00E-07"},"up","yes","Zfp667","protein_coding","chr1:67601807-67622041:-","gi|56676352|ref|NP_001008557.1|",3112,0,"zinc finger protein 667 [Rattus norvegicus]","gi|56676351|ref|NM_001008557.1|",3380,0,"Rattus norvegicus zinc finger protein 667 (Zfp667), mRNA","Q5MYW4",1201,0,"Zinc finger protein 667",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006357|regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0046872|metal ion binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSRNOG00000009291",52,4.37503397,18,1.157947887,3.778264996,1.917723891,{"v":1.77e-07,"d":"1.77E-07"},{"v":2.23E-7,"d":"2.23E-07"},"up","yes","Dnase1l3","protein_coding","chr15:16922335-16948317:+","gi|16758784|ref|NP_446359.1|",1343,{"v":2E-180,"d":"2.00E-180"},"deoxyribonuclease gamma precursor [Rattus norvegicus]","gi|56789879|gb|BC088122.1|",1017,0,"Rattus norvegicus deoxyribonuclease 1-like 3, mRNA (cDNA clone MGC:108624 IMAGE:7325326), complete cds","O89107",521,0,"Deoxyribonuclease gamma",".",".",".",".","pfam03372","Exo_endo_phos","Endonuclease/Exonuclease/phosphatase family. This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins EC:4.2.99.18, DNase I proteins EC:3.1.21.1, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56, Sphingomyelinase EC:3.1.4.12 and Nocturnin.","GO:0000737|DNA catabolic process, endonucleolytic;GO:0002283|neutrophil activation involved in immune response;GO:0002673|regulation of acute inflammatory response;GO:0006308|DNA catabolic process;GO:0006309|apoptotic DNA fragmentation;GO:0010623|programmed cell death involved in cell development;GO:0070948|regulation of neutrophil mediated cytotoxicity;","GO:0005576|extracellular region;GO:0005634|nucleus;GO:0005783|endoplasmic reticulum;","GO:0003677|DNA binding;GO:0004519|endonuclease activity;GO:0004520|endodeoxyribonuclease activity;GO:0004530|deoxyribonuclease I activity;","K11995","DNASE1L; deoxyribonuclease-1-like protein [EC:3.1.21.-]"]
["ENSRNOG00000008157",81,6.81495676,40,2.573217527,2.648418444,1.405131083,{"v":1.8E-7,"d":"1.80E-07"},{"v":2.26e-07,"d":"2.26E-07"},"up","yes","Syn2","protein_coding","chr4:148186270-148344192:+","gi|161168987|ref|NP_001104485.1|",2230,0,"synapsin-2 isoform IIa [Mus musculus]","gi|77404241|ref|NM_001034020.1|",2617,0,"Rattus norvegicus synapsin II (Syn2), transcript variant 1, mRNA","Q64332",835,0,"Synapsin-2",".",".",".",".","pfam02750","Synapsin_C","Synapsin, ATP binding domain. Ca dependent ATP binding in this ATP grasp fold. Function unknown.","GO:0007269|neurotransmitter secretion;GO:0017156|calcium ion regulated exocytosis;GO:0046928|regulation of neurotransmitter secretion;GO:0097091|synaptic vesicle clustering;GO:0099504|synaptic vesicle cycle;","GO:0005886|plasma membrane;GO:0008021|synaptic vesicle;GO:0014069|postsynaptic density;GO:0030672|synaptic vesicle membrane;GO:0031201|SNARE complex;GO:0043195|terminal bouton;GO:0045202|synapse;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098850|extrinsic component of synaptic vesicle membrane;GO:0098978|glutamatergic synapse;","GO:0005515|protein binding;GO:0005524|ATP binding;GO:0008092|cytoskeletal protein binding;GO:0042802|identical protein binding;GO:0048306|calcium-dependent protein binding;","K19941","SYN; synapsin"]
["ENSRNOG00000066880",72,6.057739343,33,2.12290446,2.853514822,1.512740057,{"v":2e-07,"d":"2.00E-07"},{"v":2.5e-07,"d":"2.50E-07"},"up","yes","ENSRNOG00000066880","lncRNA","chr2:193422585-193424032:-","gi|915668625|gb|KOC70257.1|",152,{"v":1e-07,"d":"1.00E-07"},"Thyroid receptor-interacting protein 11 [Habropoda laboriosa]","gi|354796508|gb|JN961009.1|",258,{"v":2e-130,"d":"2.00E-130"},"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Atp5f1:tm1a(EUCOMM)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam09310","PD-C2-AF1","POU domain, class 2, associating factor 1. Members of this family are transcriptional coactivators that specifically associate with either OCT1 or OCT2, through recognition of their POU domains. They are essential for the response of B-cells to antigens and required for the formation of germinal centres.",".",".",".",".","."]
["ENSRNOG00000064307",36,3.028869671,8,0.514643505,5.88537432,2.557134176,{"v":2.14e-07,"d":"2.14E-07"},{"v":2.68e-07,"d":"2.68E-07"},"up","yes","ENSRNOG00000064307","lncRNA","chr18:6367875-6447255:+",".",".",".",".","gi|672082851|ref|XR_596912.1|",1559,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102551724 (LOC102551724), transcript variant X5, ncRNA",".",".",".",".",".",".",".",".","pfam14288","FKS1_dom1","1,3-beta-glucan synthase subunit FKS1, domain-1. The FKS1_dom1 domain is likely to be the 'Class I' region just N-terminal to the first set of transmembrane helices that is involved in 1,3-beta-glucan synthesis itself. This family is found on proteins with family Glucan_synthase, pfam02364.",".",".",".",".","."]
["ENSRNOG00000025254",41,3.449546015,11,0.70763482,4.874754488,2.285329561,{"v":2.16E-7,"d":"2.16E-07"},{"v":2.7e-07,"d":"2.70E-07"},"up","yes","Qrich2","protein_coding","chr10:101669224-101697656:-","gi|672025500|ref|XP_008773826.1|",12104,0,"PREDICTED: glutamine-rich protein 2 isoform X7 [Rattus norvegicus]","gi|672025499|ref|XM_008775604.1|",5012,0,"PREDICTED: Rattus norvegicus glutamine rich 2 (Qrich2), transcript variant X7, mRNA",".",".",".",".","Rv0304c",144,{"v":3e-33,"d":"3.00E-33"},"COG5651","pfam03157","Glutenin_hmw","High molecular weight glutenin subunit. Members of this family include high molecular weight subunits of glutenin. This group of gluten proteins is thought to be largely responsible for the elastic properties of gluten, and hence, doughs. Indeed, glutenin high molecular weight subunits are classified as elastomeric proteins, because the glutenin network can withstand significant deformations without breaking, and return to the original conformation when the stress is removed. Elastomeric proteins differ considerably in amino acid sequence, but they are all polymers whose subunits consist of elastomeric domains, composed of repeated motifs, and non-elastic domains that mediate cross-linking between the subunits. The elastomeric domain motifs are all rich in glycine residues in addition to other hydrophobic residues. High molecular weight glutenin subunits have an extensive central elastomeric domain, flanked by two terminal non-elastic domains that form disulphide cross-links. The central elastomeric domain is characterized by the following three repeated motifs: PGQGQQ, GYYPTS[P/L]QQ, GQQ. It possesses overlapping beta-turns within and between the repeated motifs, and assumes a regular helical secondary structure with a diameter of approx. 1.9 nm and a pitch of approx. 1.5 nm.","GO:0030031|cell projection assembly;GO:0030317|flagellated sperm motility;GO:2000059|negative regulation of ubiquitin-dependent protein catabolic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0036126|sperm flagellum;",".","K24298","QRICH2; glutamine-rich protein 2"]
["ENSRNOG00000025354",53,4.459169238,19,1.222278326,3.648243731,1.867202116,{"v":2.24e-07,"d":"2.24E-07"},{"v":2.79E-7,"d":"2.79E-07"},"up","yes","Rinl","protein_coding","chr1:84077265-84088330:+","gi|564327101|ref|XP_006228716.1|",2681,0,"PREDICTED: ras and Rab interactor-like protein isoform X2 [Rattus norvegicus]","gi|157819766|ref|NM_001106241.1|",2990,0,"Rattus norvegicus Ras and Rab interactor-like (Rinl), mRNA","Q80UW3",846,0,"Ras and Rab interactor-like protein",".",".",".",".","pfam02204","VPS9","Vacuolar sorting protein 9 (VPS9) domain. This domain acts as a GDP-GTP exchange factor (GEF). It activates Rab GTPases by stimulating the release of GDP and allowing GTP to bind.","GO:0006897|endocytosis;GO:0050790|regulation of catalytic activity;","GO:0001726|ruffle;GO:0015629|actin cytoskeleton;","GO:0005085|guanyl-nucleotide exchange factor activity;",".","."]
["ENSRNOG00000013547",34,2.860599134,7,0.450313067,6.35246752,2.667317094,{"v":2.5e-07,"d":"2.50E-07"},{"v":3.1E-7,"d":"3.10E-07"},"up","yes","Slc6a12","protein_coding","chr4:154585500-154603750:+","gi|8394200|ref|NP_059031.1|",2850,0,"sodium- and chloride-dependent betaine transporter [Rattus norvegicus]","gi|8394199|ref|NM_017335.1|",2375,0,"Rattus norvegicus solute carrier family 6 (neurotransmitter transporter), member 12 (Slc6a12), mRNA","P48056",1075,0,"Sodium- and chloride-dependent betaine transporter","VC2012",192,{"v":8e-52,"d":"8.00E-52"},"COG0733","pfam00209","SNF","Sodium:neurotransmitter symporter family.","GO:0006836|neurotransmitter transport;GO:0009992|cellular water homeostasis;GO:0010033|response to organic substance;GO:0015718|monocarboxylic acid transport;GO:0015812|gamma-aminobutyric acid transport;GO:0035725|sodium ion transmembrane transport;GO:0055085|transmembrane transport;GO:0071474|cellular hyperosmotic response;","GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;GO:0043005|neuron projection;","GO:0005332|gamma-aminobutyric acid:sodium symporter activity;GO:0008028|monocarboxylic acid transmembrane transporter activity;","K05045","SLC6A12, BGT1; solute carrier family 6 (neurotransmitter transporter, betaine/GABA) member 12"]
["ENSRNOG00000065043",24,2.019246448,2,0.128660876,15.69433152,3.972171675,{"v":2.64e-07,"d":"2.64E-07"},{"v":3.27E-7,"d":"3.27E-07"},"up","yes","RGD1562462","protein_coding","chr13:85940078-85951004:-","gi|76827550|gb|AAI07379.1|",476,{"v":7e-56,"d":"7.00E-56"},"Pyhin1 protein [Mus musculus]","gi|672027390|ref|XR_339906.2|",676,0,"PREDICTED: Rattus norvegicus similar to Ifi204 protein (RGD1562462), misc_RNA","Q8BV49",187,{"v":1E-54,"d":"1.00E-54"},"Pyrin and HIN domain-containing protein 1",".",".",".",".","pfam02758","PYRIN","PAAD/DAPIN/Pyrin domain. This domain is predicted to contain 6 alpha helices and to have the same fold as the pfam00531 domain. This similarity may mean that this is a protein-protein interaction domain.",".",".",".",".","."]
["ENSRNOG00000068899",39,3.281275477,10,0.643304382,5.100657744,2.350683299,{"v":2.7e-07,"d":"2.70E-07"},{"v":3.35e-07,"d":"3.35E-07"},"up","yes","ENSRNOG00000068899","lncRNA","chr10:11752664-11763054:+","gi|640824451|ref|XP_008069296.1|",380,{"v":1E-59,"d":"1.00E-59"},"PREDICTED: tigger transposable element-derived protein 7 [Tarsius syrichta]","gi|672024537|ref|XR_338462.2|",2543,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102551940 (LOC102551940), ncRNA","Q6NT04",137,{"v":7e-54,"d":"7.00E-54"},"Tigger transposable element-derived protein 7",".",".",".",".","pfam03184","DDE_1","DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. Interestingly this family also includes the CENP-B protein. This domain in that protein appears to have lost the metal binding residues and is unlikely to have endonuclease activity. Centromere Protein B (CENP-B) is a DNA-binding protein localized to the centromere.",".",".",".",".","."]
["ENSRNOG00000009730",80,6.730821492,40,2.573217527,2.61572192,1.387209175,{"v":2.79E-7,"d":"2.79E-07"},{"v":3.46E-7,"d":"3.46E-07"},"up","yes","Cyp7b1","protein_coding","chr2:100502791-100669698:-","gi|149048513|gb|EDM01054.1|",2391,0,"cytochrome P450, family 7, subfamily b, polypeptide 1 [Rattus norvegicus]","gi|158186666|ref|NM_019138.1|",2614,0,"Rattus norvegicus cytochrome P450, family 7, subfamily b, polypeptide 1 (Cyp7b1), mRNA","Q63688",786,0,"25-hydroxycholesterol 7-alpha-hydroxylase (Fragment)","YHR007c",82.4,{"v":2e-15,"d":"2.00E-15"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0006699|bile acid biosynthetic process;GO:0007613|memory;GO:0007623|circadian rhythm;GO:0008203|cholesterol metabolic process;GO:0009410|response to xenobiotic stimulus;GO:0033147|negative regulation of intracellular estrogen receptor signaling pathway;GO:0035754|B cell chemotaxis;GO:0042632|cholesterol homeostasis;GO:0050679|positive regulation of epithelial cell proliferation;GO:0051591|response to cAMP;GO:0060740|prostate gland epithelium morphogenesis;","GO:0005575|cellular_component;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0004497|monooxygenase activity;GO:0005506|iron ion binding;GO:0008395|steroid hydroxylase activity;GO:0008396|oxysterol 7-alpha-hydroxylase activity;GO:0016705|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0020037|heme binding;GO:0033783|25-hydroxycholesterol 7alpha-hydroxylase activity;GO:0047092|27-hydroxycholesterol 7-alpha-monooxygenase activity;","K07430","CYP7B; 25/26-hydroxycholesterol 7alpha-hydroxylase [EC:1.14.14.29]"]
["ENSRNOG00000016950",129,10.85344966,83,5.339426369,2.032699564,1.023396999,{"v":2.97e-07,"d":"2.97E-07"},{"v":3.67e-07,"d":"3.67E-07"},"up","yes","Otud1","protein_coding","chr17:82259840-82262995:+","gi|293354776|ref|XP_574086.3|",1479,0,"PREDICTED: OTU domain-containing protein 1 isoform X2 [Rattus norvegicus]","gi|672082584|ref|XM_574086.6|",2924,0,"PREDICTED: Rattus norvegicus OTU deubiquitinase 1 (Otud1), transcript variant X2, mRNA","Q9CUB6",530,{"v":2E-176,"d":"2.00E-176"},"OTU domain-containing protein 1",".",".",".",".","pfam02338","OTU","OTU-like cysteine protease. This family is comprised of a group of predicted cysteine proteases, homologous to the Ovarian tumor (OTU) gene in Drosophila. Members include proteins from eukaryotes, viruses and pathogenic bacterium. The conserved cysteine and histidine, and possibly the aspartate, represent the catalytic residues in this putative group of proteases.","GO:0016579|protein deubiquitination;GO:0070536|protein K63-linked deubiquitination;",".","GO:0004843|thiol-dependent ubiquitin-specific protease activity;","K13716","OTUD1; OTU domain-containing protein 1 [EC:3.4.19.12]"]
["ENSRNOG00000021018",28,2.355787522,4,0.257321753,9.155026721,3.194564097,{"v":3.11e-07,"d":"3.11E-07"},{"v":3.83e-07,"d":"3.83E-07"},"up","yes","ENSRNOG00000021018","protein_coding","chr1:203468097-203475889:+","gi|293344572|ref|XP_001071505.2|",1049,{"v":1e-140,"d":"1.00E-140"},"PREDICTED: basic leucine zipper transcriptional factor ATF-like 2 isoform X3 [Rattus norvegicus]","gi|672014615|ref|XM_001071505.4|",880,0,"PREDICTED: Rattus norvegicus basic leucine zipper transcription factor, ATF-like 2 (Batf2), transcript variant X4, mRNA","Q8R1H8",318,{"v":2e-106,"d":"2.00E-106"},"Basic leucine zipper transcriptional factor ATF-like 2",".",".",".",".","pfam02183","HALZ","Homeobox associated leucine zipper.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0042832|defense response to protozoan;GO:0043011|myeloid dendritic cell differentiation;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;","K09034","BATF; ATF-like basic leucine zipper transcriptional factor"]
["ENSRNOG00000006119",48,4.038492895,16,1.029287011,3.92358288,1.972171675,{"v":3.2e-07,"d":"3.20E-07"},{"v":3.93e-07,"d":"3.93E-07"},"up","yes","Slc7a15","protein_coding","chr6:31403747-31415231:-","gi|157821903|ref|NP_001100184.1|",2377,0,"solute carrier family 7 (cationic amino acid transporter, y+ system), member 15 [Rattus norvegicus]","gi|157821902|ref|NM_001106714.1|",2425,0,"Rattus norvegicus solute carrier family 7 (cationic amino acid transporter, y+ system), member 15 (Slc7a15), mRNA","P82251",381,{"v":3e-121,"d":"3.00E-121"},"b(0,+)-type amino acid transporter 1","BS_ykbA",136,{"v":2e-33,"d":"2.00E-33"},"COG0531","pfam13520","AA_permease_2","Amino acid permease.","GO:0003333|amino acid transmembrane transport;GO:0015807|L-amino acid transport;GO:1902475|L-alpha-amino acid transmembrane transport;","GO:0016021|integral component of membrane;GO:0032991|protein-containing complex;","GO:0015179|L-amino acid transmembrane transporter activity;","K13868","SLC7A9_15, BAT1; solute carrier family 7 (L-type amino acid transporter), member 9/15"]
["ENSRNOG00000026594",45,3.786087089,14,0.900626135,4.2038388,2.071707349,{"v":3.22E-7,"d":"3.22E-07"},{"v":3.96E-7,"d":"3.96E-07"},"up","yes","Tmem61","protein_coding","chr5:121266799-121276057:-","gi|564305792|ref|XP_006225489.1|",885,{"v":8E-116,"d":"8.00E-116"},"PREDICTED: transmembrane protein 61 [Rattus norvegicus]","gi|672019676|ref|XM_006225427.2|",1074,0,"PREDICTED: Rattus norvegicus uncharacterized LOC100909776 (LOC100909776), mRNA","Q8N0U2",138,{"v":5e-37,"d":"5.00E-37"},"Transmembrane protein 61",".",".",".",".","pfam15105","TMEM61","TMEM61 protein family. The function of this family of transmembrane proteins has not, as yet, been determined. Members of this family remain uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 150 and 211 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000011497",55,4.627439776,21,1.350939202,3.425350134,1.776251465,{"v":3.43e-07,"d":"3.43E-07"},{"v":4.21e-07,"d":"4.21E-07"},"up","yes","Aldh1b1","protein_coding","chr5:60063225-60068378:+","gi|149045822|gb|EDL98822.1|",2631,0,"rCG55098 [Rattus norvegicus]","gi|58865517|ref|NM_001011975.1|",2194,0,"Rattus norvegicus aldehyde dehydrogenase 1 family, member B1 (Aldh1b1), mRNA","Q66HF8",1015,0,"Aldehyde dehydrogenase X, mitochondrial","SPAC9E9.09c",499,{"v":1E-167,"d":"1.00E-167"},"COG1012","pfam00171","Aldedh","Aldehyde dehydrogenase family. This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:1.2.1.3. Succinate-semialdehyde dehydrogenase EC:1.2.1.16. Lactaldehyde dehydrogenase EC:1.2.1.22. Benzaldehyde dehydrogenase EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase EC: 1.5.1.12. Acetaldehyde dehydrogenase EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase EC:1.2.1.41. This family also includes omega crystallin, an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.","GO:0006068|ethanol catabolic process;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005739|mitochondrion;GO:0005759|mitochondrial matrix;GO:0005829|cytosol;GO:0043231|intracellular membrane-bounded organelle;","GO:0003674|molecular_function;GO:0004029|aldehyde dehydrogenase (NAD) activity;GO:0016620|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor;GO:0043878|glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity;","K00128","ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]"]
["ENSRNOG00000002950",108,9.086609014,65,4.181478482,2.173061288,1.119728864,{"v":4.51E-7,"d":"4.51E-07"},{"v":5.46e-07,"d":"5.46E-07"},"up","yes","Lyl1","protein_coding","chr19:23452140-23455007:-","gi|56090489|ref|NP_001007678.1|",1254,{"v":1E-168,"d":"1.00E-168"},"protein lyl-1 [Rattus norvegicus]","gi|56090488|ref|NM_001007677.1|",1459,0,"Rattus norvegicus lymphoblastic leukemia associated hematopoiesis regulator 1 (Lyl1), mRNA","Q66HH3",487,{"v":5e-170,"d":"5.00E-170"},"Protein lyl-1",".",".",".",".","pfam00010","HLH","Helix-loop-helix DNA-binding domain.","GO:0001955|blood vessel maturation;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008150|biological_process;GO:0030183|B cell differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0060216|definitive hemopoiesis;","GO:0005575|cellular_component;GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0046983|protein dimerization activity;","K15604","LYL1; protein lyl-1"]
["ENSRNOG00000031782",33,2.776463865,7,0.450313067,6.16563024,2.624248372,{"v":4.73e-07,"d":"4.73E-07"},{"v":5.7e-07,"d":"5.70E-07"},"up","yes","Col6a4","protein_coding","chr8:106617050-106733263:-","gi|161788949|dbj|BAF95091.1|",8833,0,"double von Willebrand factor A domains [Mus musculus]","gi|403225004|ref|NM_001271182.1|",4350,0,"Rattus norvegicus collagen, type VI, alpha 4 (Col6a4), mRNA","A2AX52",3401,0,"Collagen alpha-4(VI) chain",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0030198|extracellular matrix organization;",".",".","K06238","COL6A; collagen type VI alpha"]
["ENSRNOG00000066870",33,2.776463865,7,0.450313067,6.16563024,2.624248372,{"v":4.73e-07,"d":"4.73E-07"},{"v":5.7e-07,"d":"5.70E-07"},"up","yes","ENSRNOG00000066870","protein_coding","chr3:109505663-109535168:+","gi|15721849|gb|AAK38150.1|",3246,0,"concentrative Na+ nucleoside cotransporter [Rattus norvegicus]","gi|13928919|ref|NM_031664.1|",2575,0,"Rattus norvegicus solute carrier family 28 member 2 (Slc28a2), mRNA","Q62773",1252,0,"Sodium/nucleoside cotransporter 2","all0378",347,{"v":1E-108,"d":"1.00E-108"},"COG1972","pfam07662","Nucleos_tra2_C","Na+ dependent nucleoside transporter C-terminus. This family consists of nucleoside transport proteins. Members include a purine-specific Na+-nucleoside cotransporter localized to the bile canalicular membrane and a Na+-dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine, which also transports the anti-viral nucleoside analogues AZT and ddC. This alignment covers the C-terminus of this family of transporters.",".",".",".",".","."]
["ENSRNOG00000005370",38,3.197140209,10,0.643304382,4.969871648,2.313208593,{"v":4.95e-07,"d":"4.95E-07"},{"v":5.95e-07,"d":"5.95E-07"},"up","yes","S1pr4","protein_coding","chr7:8208098-8211893:+","gi|157823827|ref|NP_001101545.1|",1752,0,"sphingosine 1-phosphate receptor 4 [Rattus norvegicus]","gi|157823826|ref|NM_001108075.1|",1270,0,"Rattus norvegicus sphingosine-1-phosphate receptor 4 (S1pr4), mRNA","Q9Z0L1",591,0,"Sphingosine 1-phosphate receptor 4",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0003376|sphingosine-1-phosphate receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0019222|regulation of metabolic process;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0038036|sphingosine-1-phosphate receptor activity;","K04293","S1PR4, EDG6; sphingosine 1-phosphate receptor 4"]
["ENSRNOG00000015445",38,3.197140209,10,0.643304382,4.969871648,2.313208593,{"v":4.95e-07,"d":"4.95E-07"},{"v":5.95e-07,"d":"5.95E-07"},"up","yes","Mal","protein_coding","chr3:114864378-114888136:-","gi|6981178|ref|NP_036930.1|",656,{"v":8E-78,"d":"8.00E-78"},"myelin and lymphocyte protein [Rattus norvegicus]","gi|6981177|ref|NM_012798.1|",2237,0,"Rattus norvegicus mal, T-cell differentiation protein (Mal), mRNA","Q64349",257,{"v":3E-79,"d":"3.00E-79"},"Myelin and lymphocyte protein",".",".",".",".","pfam01284","MARVEL","Membrane-associating domain. MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.","GO:0002175|protein localization to paranode region of axon;GO:0006886|intracellular protein transport;GO:0042552|myelination;GO:0098737|protein insertion into plasma membrane;GO:1902043|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors;","GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0019898|extrinsic component of membrane;GO:0044853|plasma membrane raft;GO:0045121|membrane raft;GO:0120003|hinge region between urothelial plaques of apical plasma membrane;","GO:0019911|structural constituent of myelin sheath;",".","."]
["ENSRNOG00000037190",38,3.197140209,10,0.643304382,4.969871648,2.313208593,{"v":4.95e-07,"d":"4.95E-07"},{"v":5.95e-07,"d":"5.95E-07"},"up","yes","Cd101","protein_coding","chr2:188422351-188459502:-","gi|403420584|ref|NP_001258146.1|",5177,0,"immunoglobulin superfamily member 2 precursor [Rattus norvegicus]","gi|672043656|ref|XM_006233049.2|",3211,0,"PREDICTED: Rattus norvegicus CD101 molecule (Cd101), transcript variant X2, mRNA","A8E0Y8",1749,0,"Immunoglobulin superfamily member 2",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0002763|positive regulation of myeloid leukocyte differentiation;","GO:0016021|integral component of membrane;",".","K06522","IGSF2_3, CD101; immunoglobulin superfamily, member 2/3"]
["ENSRNOG00000025645",23,1.935111179,2,0.128660876,15.04040104,3.910771131,{"v":5.32e-07,"d":"5.32E-07"},{"v":6.38e-07,"d":"6.38E-07"},"up","yes","Abca13","protein_coding","chr14:83873940-84375075:+","gi|158187533|ref|NP_001099490.2|",25879,0,"ATP-binding cassette, sub-family A (ABC1), member 13 [Rattus norvegicus]","gi|158187532|ref|NM_001106020.2|",14919,0,"Rattus norvegicus ATP-binding cassette, subfamily A (ABC1), member 13 (Abca13), mRNA","Q5SSE9",8673,0,"ATP-binding cassette sub-family A member 13","PAE0269",173,{"v":4e-45,"d":"4.00E-45"},"COG1131","pfam00005","ABC_tran","ABC transporter. ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide or belong in different polypeptide chains.","GO:0006869|lipid transport;GO:0008150|biological_process;GO:0032376|positive regulation of cholesterol transport;GO:0035627|ceramide transport;GO:0055085|transmembrane transport;GO:1900244|positive regulation of synaptic vesicle endocytosis;","GO:0005575|cellular_component;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0097708|intracellular vesicle;","GO:0003674|molecular_function;GO:0005319|lipid transporter activity;GO:0005524|ATP binding;GO:0042626|ATPase activity, coupled to transmembrane movement of substances;","K05647","ABCA13; ATP binding cassette, subfamily A (ABC1), member 13"]
["ENSRNOG00000042455",23,1.935111179,2,0.128660876,15.04040104,3.910771131,{"v":5.32e-07,"d":"5.32E-07"},{"v":6.38e-07,"d":"6.38E-07"},"up","yes","Tlr12","protein_coding","chr5:140959996-140964816:-","gi|672054117|ref|XP_008762370.1|",3846,0,"PREDICTED: toll-like receptor 12 isoform X1 [Rattus norvegicus]","gi|672054116|ref|XM_008764148.1|",3536,0,"PREDICTED: Rattus norvegicus toll-like receptor 12 (Tlr12), transcript variant X1, mRNA","Q6QNU9",1125,0,"Toll-like receptor 12",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.","GO:0002224|toll-like receptor signaling pathway;GO:0006954|inflammatory response;GO:0045087|innate immune response;","GO:0005887|integral component of plasma membrane;","GO:0003953|NAD+ nucleosidase activity;GO:0004888|transmembrane signaling receptor activity;GO:0038023|signaling receptor activity;","K18807","TLR12; toll-like receptor 12"]
["ENSRNOG00000014007",31,2.608193328,6,0.385982629,6.757281627,2.756442984,{"v":5.39e-07,"d":"5.39E-07"},{"v":6.46e-07,"d":"6.46E-07"},"up","yes","Gfod1","protein_coding","chr17:21399479-21499938:+","gi|281332180|ref|NP_001163805.1|",2093,0,"glucose-fructose oxidoreductase domain-containing protein 1 [Rattus norvegicus]","gi|672081473|ref|XM_006253805.2|",1427,0,"PREDICTED: Rattus norvegicus glucose-fructose oxidoreductase domain containing 1 (Gfod1), transcript variant X1, mRNA","Q3UHD2",808,0,"Glucose-fructose oxidoreductase domain-containing protein 1",".",".",".",".","pfam01408","GFO_IDH_MocA","Oxidoreductase family, NAD-binding Rossmann fold. This family of enzymes utilize NADP or NAD. This family is called the GFO/IDH/MOCA family in swiss-prot.",".",".","GO:0000166|nucleotide binding;GO:0016491|oxidoreductase activity;",".","."]
["ENSRNOG00000012989",44,3.70195182,14,0.900626135,4.11042016,2.039285871,{"v":5.68E-7,"d":"5.68E-07"},{"v":6.78e-07,"d":"6.78E-07"},"up","yes","Serinc2","protein_coding","chr5:142592309-142618364:-","gi|72255537|ref|NP_001026826.1|",1967,0,"serine incorporator 2 precursor [Rattus norvegicus]","gi|72255536|ref|NM_001031656.1|",1803,0,"Rattus norvegicus serine incorporator 2 (Serinc2), mRNA","Q8K0E7",747,0,"Serine incorporator 2",".",".",".",".","pfam03348","Serinc","Serine incorporator (Serinc). This is a family of eukaryotic membrane proteins which incorporate serine into membranes and facilitate the synthesis of the serine-derived lipids phosphatidylserine and sphingolipid. Members of this family contain 11 transmembrane domains and form intracellular complexes with key enzymes involved in serine and sphingolipid biosynthesis.","GO:0006658|phosphatidylserine metabolic process;GO:0006665|sphingolipid metabolic process;GO:1904219|positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity;GO:1904222|positive regulation of serine C-palmitoyltransferase activity;","GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0030674|protein binding, bridging;","K24176","SERINC2; serine incorporator 2"]
["ENSRNOG00000065916",20,1.682705373,0,0.032165219,52.3144384,5.70913727,{"v":5.78e-07,"d":"5.78E-07"},{"v":6.9e-07,"d":"6.90E-07"},"up","yes","ENSRNOG00000065916","lncRNA","chr3:147154097-147160490:+","gi|293358231|ref|XP_002729292.1|",411,{"v":7e-47,"d":"7.00E-47"},"PREDICTED: adipogenin-like [Rattus norvegicus]","gi|672047855|ref|XM_002729246.3|",663,0,"PREDICTED: Rattus norvegicus adipogenin (Adig), mRNA","Q8R400",139,{"v":2e-39,"d":"2.00E-39"},"Adipogenin",".",".",".",".","pfam15202","Adipogenin","Adipogenin. This family of proteins is involved in the stimulation of adipocyte differentiation and development.",".",".",".",".","."]
["ENSRNOG00000029564",29,2.439922791,5,0.321652191,7.585593568,2.923262075,{"v":5.91e-07,"d":"5.91E-07"},{"v":7.04e-07,"d":"7.04E-07"},"up","yes","Trat1","protein_coding","chr11:52035750-52077805:+","gi|83816943|ref|NP_001033070.1|",816,{"v":2e-102,"d":"2.00E-102"},"T cell receptor associated transmembrane adaptor 1 [Rattus norvegicus]","gi|83816942|ref|NM_001037981.1|",1820,0,"Rattus norvegicus T cell receptor associated transmembrane adaptor 1 (Trat1), mRNA","Q3UU67",282,{"v":1E-89,"d":"1.00E-89"},"T-cell receptor-associated transmembrane adapter 1",".",".",".",".","pfam15330","SIT","SHP2-interacting transmembrane adaptor protein, SIT. SIT, or SHP2-interacting transmembrane adaptor protein, is a disulfide-linked dimer that regulates human T Cell activation.","GO:0001920|negative regulation of receptor recycling;GO:0050850|positive regulation of calcium-mediated signaling;GO:0050862|positive regulation of T cell receptor signaling pathway;GO:0051051|negative regulation of transport;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0034451|centriolar satellite;GO:0042101|T cell receptor complex;GO:0072686|mitotic spindle;",".",".","."]
["ENSRNOG00000067378",29,2.439922791,5,0.321652191,7.585593568,2.923262075,{"v":5.91e-07,"d":"5.91E-07"},{"v":7.04e-07,"d":"7.04E-07"},"up","yes","ENSRNOG00000067378","protein_coding","chr10:52009425-52068951:+","gi|124486959|ref|NP_001074719.1|",9264,0,"myosin-13 [Mus musculus]","gi|672025636|ref|XM_008775758.1|",5161,0,"PREDICTED: Rattus norvegicus myosin-13 (LOC103693367), transcript variant X1, mRNA","Q9UKX3",3430,0,"Myosin-13","SPCC645.05c",729,0,"COG5022","pfam01576","Myosin_tail_1","Myosin tail. The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.",".",".",".",".","."]
["ENSRNOG00000068008",36,3.028869671,9,0.578973944,5.23144384,2.387209175,{"v":6.15e-07,"d":"6.15E-07"},{"v":7.31e-07,"d":"7.31E-07"},"up","yes","ENSRNOG00000068008","lncRNA","chr6:124365829-124398449:+","gi|564357199|ref|XP_006240598.1|",810,{"v":6e-95,"d":"6.00E-95"},"PREDICTED: putative uncharacterized protein C14orf132 homolog [Rattus norvegicus]","gi|672057098|ref|XM_006240536.2|",2055,0,"PREDICTED: Rattus norvegicus uncharacterized LOC100909954 (LOC100909954), mRNA","Q9NPU4",120,{"v":2e-29,"d":"2.00E-29"},"Uncharacterized protein C14orf132",".",".",".",".","pfam15498","Dendrin","Nephrin and CD2AP-binding protein, Dendrin. Dendrin is a family of eukaryotic proteins found in the podocytes of the kidneys. Dendrin, originally identified in telencephalic dendrites, is a constituent of the slit diaphragm, SD, complex of podocytes, where it directly binds to nephrin and CD2AP. Kidney podocytes and their slit diaphragms (SDs) form the final barrier to urinary protein loss. SD proteins also participate in intracellular signalling pathways. Dendrin appears to prevent programmed cell death (apoptosis) through its binding to nephrin. The SD protein nephrin serves as a component of a signalling complex that directly links podocyte junctional integrity to actin cytoskeletal dynamics. Thus, dendrin is identified as an SD family with proapoptotic signalling properties that accumulates in the podocyte nucleus in response to glomerular injury.",".",".",".",".","."]
["ENSRNOG00000003170",64,5.384657193,29,1.865582707,2.886313843,1.52922818,{"v":7.74e-07,"d":"7.74E-07"},{"v":9.14e-07,"d":"9.14E-07"},"up","yes","Nlrp3","protein_coding","chr10:44328566-44352811:+","gi|300798702|ref|NP_001178571.1|",5138,0,"NACHT, LRR and PYD domains-containing protein 3 [Rattus norvegicus]","gi|300798701|ref|NM_001191642.1|",3857,0,"Rattus norvegicus NLR family, pyrin domain containing 3 (Nlrp3), mRNA","D4A523",1982,0,"NACHT, LRR and PYD domains-containing protein 3",".",".",".",".","pfam05729","NACHT","NACHT domain. This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.","GO:0002523|leukocyte migration involved in inflammatory response;GO:0002526|acute inflammatory response;GO:0002674|negative regulation of acute inflammatory response;GO:0002720|positive regulation of cytokine production involved in immune response;GO:0002830|positive regulation of type 2 immune response;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006954|inflammatory response;GO:0014070|response to organic cyclic compound;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0032691|negative regulation of interleukin-1 beta production;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032736|positive regulation of interleukin-13 production;GO:0032753|positive regulation of interleukin-4 production;GO:0032754|positive regulation of interleukin-5 production;GO:0043280|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0044546|NLRP3 inflammasome complex assembly;GO:0045087|innate immune response;GO:0045471|response to ethanol;GO:0045630|positive regulation of T-helper 2 cell differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050727|regulation of inflammatory response;GO:0050728|negative regulation of inflammatory response;GO:0050830|defense response to Gram-positive bacterium;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051607|defense response to virus;GO:0071222|cellular response to lipopolysaccharide;GO:0071224|cellular response to peptidoglycan;GO:1901223|negative regulation of NIK/NF-kappaB signaling;GO:2000321|positive regulation of T-helper 17 cell differentiation;GO:2000553|positive regulation of T-helper 2 cell cytokine production;","GO:0000139|Golgi membrane;GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0061702|inflammasome complex;GO:0072559|NLRP3 inflammasome complex;","GO:0003674|molecular_function;GO:0005524|ATP binding;GO:0042802|identical protein binding;GO:0043565|sequence-specific DNA binding;","K12800","NLRP3, PYPAF1; NACHT, LRR and PYD domains-containing protein 3"]
["ENSRNOG00000017680",60,5.048116119,26,1.672591393,3.018140677,1.593660052,{"v":8.18e-07,"d":"8.18E-07"},{"v":9.64E-7,"d":"9.64E-07"},"up","yes","Dennd2d","protein_coding","chr2:193973231-193992270:+","gi|672043761|ref|XP_008759619.1|",2574,0,"PREDICTED: DENN domain-containing protein 2D isoform X2 [Rattus norvegicus]","gi|672043760|ref|XM_008761397.1|",2323,0,"PREDICTED: Rattus norvegicus DENN/MADD domain containing 2D (Dennd2d), transcript variant X2, mRNA","Q91VV4",766,0,"DENN domain-containing protein 2D",".",".",".",".","pfam02141","DENN","DENN (AEX-3) domain. DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.","GO:0050790|regulation of catalytic activity;","GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0005085|guanyl-nucleotide exchange factor activity;","K20161","DENND2; DENN domain-containing protein 2"]
["ENSRNOG00000066155",56,4.711575044,23,1.479600078,3.18435712,1.671002141,{"v":8.29e-07,"d":"8.29E-07"},{"v":9.75e-07,"d":"9.75E-07"},"up","yes","ENSRNOG00000066155","lncRNA","chr1:221567754-221569491:-",".",".",".",".","gi|672040017|ref|XM_006231185.2|",1738,0,"PREDICTED: Rattus norvegicus amyloid beta (A4) precursor protein-binding, family A, member 1 (Apba1), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.",".",".",".",".","."]
["ENSRNOG00000050509",113,9.507285357,71,4.567461111,2.08152519,1.057641018,{"v":8.3e-07,"d":"8.30E-07"},{"v":9.77e-07,"d":"9.77E-07"},"up","yes","Ebi3","protein_coding","chr9:783617-787544:+","gi|157821551|ref|NP_001102891.1|",1124,{"v":4e-151,"d":"4.00E-151"},"interleukin-27 subunit beta precursor [Rattus norvegicus]","gi|157821550|ref|NM_001109421.1|",1162,0,"Rattus norvegicus Epstein-Barr virus induced 3 (Ebi3), mRNA","O35228",378,{"v":2e-129,"d":"2.00E-129"},"Interleukin-27 subunit beta",".",".",".",".","pfam09294","Interfer-bind","Interferon-alpha/beta receptor, fibronectin type III. Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.","GO:0019221|cytokine-mediated signaling pathway;GO:0033210|leptin-mediated signaling pathway;GO:0042098|T cell proliferation;","GO:0009897|external side of plasma membrane;GO:0043235|receptor complex;","GO:0004896|cytokine receptor activity;GO:0017046|peptide hormone binding;GO:0019955|cytokine binding;GO:0045523|interleukin-27 receptor binding;","K24476","EBI3, IL27B; interleukin 27 subunit beta"]
["ENSRNOG00000005903",104,8.750067939,63,4.052817606,2.159008569,1.110368969,{"v":8.73e-07,"d":"8.73E-07"},{"v":1.03e-06,"d":"1.03E-06"},"up","yes","St14","protein_coding","chr8:29540811-29581517:-","gi|16758444|ref|NP_446087.1|",4509,0,"suppressor of tumorigenicity 14 protein [Rattus norvegicus]","gi|31377480|ref|NM_053635.2|",3150,0,"Rattus norvegicus suppression of tumorigenicity 14 (St14), mRNA","P56677",1661,0,"Suppressor of tumorigenicity 14 protein homolog","VC1200",112,{"v":3e-25,"d":"3.00E-25"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0001843|neural tube closure;GO:0006508|proteolysis;GO:0030216|keratinocyte differentiation;GO:0060672|epithelial cell morphogenesis involved in placental branching;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0019897|extrinsic component of plasma membrane;","GO:0004252|serine-type endopeptidase activity;GO:0008236|serine-type peptidase activity;","K08670","ST14, PRSS14; suppressor of tumorigenicity protein 14 [EC:3.4.21.109]"]
["ENSRNOG00000019477",106,8.918338477,65,4.181478482,2.132819412,1.092761816,{"v":9.5e-07,"d":"9.50E-07"},{"v":1.11E-6,"d":"1.11E-06"},"up","yes","Zmynd15","protein_coding","chr10:55171198-55177812:+","gi|157786632|ref|NP_001099270.1|",3202,0,"zinc finger MYND domain-containing protein 15 [Rattus norvegicus]","gi|157786631|ref|NM_001105800.1|",2879,0,"Rattus norvegicus zinc finger, MYND-type containing 15 (Zmynd15), mRNA","Q8C0R7",1193,0,"Zinc finger MYND domain-containing protein 15",".",".",".",".","pfam01753","zf-MYND","MYND finger.","GO:0007286|spermatid development;GO:0045892|negative regulation of transcription, DNA-templated;","GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0042826|histone deacetylase binding;","K24081","ZMYND15; zinc finger MYND domain-containing protein 15"]
["ENSRNOG00000069610",71,5.973604074,35,2.251565336,2.653089376,1.407673277,{"v":9.92e-07,"d":"9.92E-07"},{"v":1.16e-06,"d":"1.16E-06"},"up","yes","ENSRNOG00000069610","lncRNA","chr6:130965889-130967437:-","gi|67078514|ref|NP_001019920.1|",568,{"v":2e-67,"d":"2.00E-67"},"UPF0235 protein C15orf40 homolog [Rattus norvegicus]","gi|672021182|ref|XM_003754243.3|",1196,0,"PREDICTED: Rattus norvegicus hypothetical protein LOC100363116 (LOC100363116), mRNA","Q505I4",223,{"v":7e-69,"d":"7.00E-69"},"UPF0235 protein C15orf40 homolog","VC0458",57.4,{"v":4e-09,"d":"4.00E-09"},"COG1872","pfam02594","DUF167","Uncharacterized ACR, YggU family COG1872.",".",".",".",".","."]
["ENSRNOG00000022094",108,9.086609014,67,4.310139358,2.108193786,1.076007486,{"v":1.03e-06,"d":"1.03E-06"},{"v":1.2e-06,"d":"1.20E-06"},"up","yes","Lacc1","protein_coding","chr15:52395183-52407545:-","gi|27663906|ref|XP_233749.1|",2306,0,"PREDICTED: laccase domain-containing protein 1 [Rattus norvegicus]","gi|672028748|ref|XM_001072262.4|",2190,0,"PREDICTED: Rattus norvegicus laccase (multicopper oxidoreductase) domain containing 1 (Lacc1), mRNA","Q8BZT9",780,0,"Laccase domain-containing protein 1","BS_ylmD",110,{"v":2e-25,"d":"2.00E-25"},"COG1496","pfam02578","Cu-oxidase_4","Multi-copper polyphenol oxidoreductase laccase. Laccases are multi-copper oxidoreductases able to oxidize a wide variety of phenolic and non-phenolic compounds and are widely distributed among both prokaryotes and eukaryotes. There are two main active catalytic sites with conserved histidines that are capable of binding four copper atoms.","GO:0002221|pattern recognition receptor signaling pathway;GO:0002720|positive regulation of cytokine production involved in immune response;GO:0030641|regulation of cellular pH;GO:0050727|regulation of inflammatory response;GO:0070431|nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:1900542|regulation of purine nucleotide metabolic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005777|peroxisome;GO:0005783|endoplasmic reticulum;","GO:0004000|adenosine deaminase activity;GO:0004731|purine-nucleoside phosphorylase activity;GO:0005507|copper ion binding;GO:0017061|S-methyl-5-thioadenosine phosphorylase activity;GO:0047975|guanosine phosphorylase activity;","K05810","LACC1, yfiH; purine-nucleoside/S-methyl-5'-thioadenosine phosphorylase / adenosine deaminase [EC:2.4.2.1 2.4.2.28 3.5.4.4]"]
["ENSRNOG00000030541",22,1.85097591,2,0.128660876,14.38647056,3.846640793,{"v":1.07e-06,"d":"1.07E-06"},{"v":1.25e-06,"d":"1.25E-06"},"up","yes","Ccdc154","protein_coding","chr10:14177278-14187253:+","gi|672024599|ref|XP_008772921.1|",3256,0,"PREDICTED: coiled-coil domain-containing protein 154 [Rattus norvegicus]","gi|672024598|ref|XM_008774699.1|",2631,0,"PREDICTED: Rattus norvegicus coiled-coil domain containing 154 (Ccdc154), mRNA","Q6RUT8",1036,0,"Coiled-coil domain-containing protein 154",".",".",".",".","pfam15450","DUF4631","Domain of unknown function (DUF4631). This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 394 and 668 amino acids in length.","GO:0035630|bone mineralization involved in bone maturation;GO:0042475|odontogenesis of dentin-containing tooth;GO:0044691|tooth eruption;GO:0045453|bone resorption;",".",".",".","."]
["ENSRNOG00000066615",22,1.85097591,2,0.128660876,14.38647056,3.846640793,{"v":1.07e-06,"d":"1.07E-06"},{"v":1.25e-06,"d":"1.25E-06"},"up","yes","ENSRNOG00000066615","protein_coding","chr4:162690665-162705515:+","gi|149029577|gb|EDL84768.1|",595,{"v":1e-65,"d":"1.00E-65"},"rCG23031 [Rattus norvegicus]","gi|14318383|gb|AC087041.2|",469,0,"Rattus norvegicus strain Brown Norway clone RP31-188L2, complete sequence",".",".",".",".",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type",".",".",".",".","."]
["ENSRNOG00000048321",19,1.598570104,0,0.032165219,49.69871648,5.635136688,{"v":1.11E-6,"d":"1.11E-06"},{"v":1.3E-6,"d":"1.30E-06"},"up","yes","Tnfsf8","protein_coding","chr5:77251373-77277421:-","gi|974987285|ref|NP_001305962.1|",1157,{"v":4e-146,"d":"4.00E-146"},"tumor necrosis factor superfamily member 8 [Rattus norvegicus]","gi|672019461|ref|XM_006225345.2|",2905,0,"PREDICTED: Rattus norvegicus tumor necrosis factor (ligand) superfamily, member 8 (Tnfsf8), transcript variant X2, mRNA","P32972",397,{"v":1E-127,"d":"1.00E-127"},"Tumor necrosis factor ligand superfamily member 8",".",".",".",".","pfam00229","TNF","TNF(tumor Necrosis Factor) family.","GO:0043374|CD8-positive, alpha-beta T cell differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050830|defense response to Gram-positive bacterium;","GO:0016021|integral component of membrane;","GO:0005164|tumor necrosis factor receptor binding;","K05471","TNFSF8, CD153; tumor necrosis factor ligand superfamily member 8"]
["ENSRNOG00000070418",24,2.019246448,3,0.192991315,10.46288768,3.387209175,{"v":1.19E-6,"d":"1.19E-06"},{"v":1.38e-06,"d":"1.38E-06"},"up","yes","ENSRNOG00000070418","lncRNA","chr17:67147484-67153664:-","gi|149063954|gb|EDM14224.1|",160,{"v":1e-09,"d":"1.00E-09"},"rCG23351 [Rattus norvegicus]","gi|672082524|ref|XR_596844.1|",1803,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102553434 (LOC102553434), ncRNA",".",".",".",".",".",".",".",".","pfam00684","DnaJ_CXXCXGXG","DnaJ central domain. The central cysteine-rich (CR) domain of DnaJ proteins contains four repeats of the motif CXXCXGXG where X is any amino acid. The isolated cysteine rich domain folds in zinc dependent fashion. Each set of two repeats binds one unit of zinc. Although this domain has been implicated in substrate binding, no evidence of specific interaction between the isolated DNAJ cysteine rich domain and various hydrophobic peptides has been found.",".",".",".",".","."]
["ENSRNOG00000021560",47,3.954357626,17,1.093617449,3.61585089,1.854335185,{"v":1.21e-06,"d":"1.21E-06"},{"v":1.41e-06,"d":"1.41E-06"},"up","yes","Cass4","protein_coding","chr3:161163436-161202186:+","gi|564344734|ref|XP_006235741.1|",4005,0,"PREDICTED: cas scaffolding protein family member 4 isoform X1 [Rattus norvegicus]","gi|672048056|ref|XM_006235679.2|",3610,0,"PREDICTED: Rattus norvegicus Cas scaffolding protein family member 4 (Cass4), transcript variant X1, mRNA","Q08EC4",1264,0,"Cas scaffolding protein family member 4",".",".",".",".","pfam08824","Serine_rich","Serine rich protein interaction domain. This is a serine rich domain that is found in the docking protein p130(cas) (Crk-associated substrate). This domain folds into a four helix bundle which is associated with protein-protein interactions.","GO:0007155|cell adhesion;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0016477|cell migration;GO:0030335|positive regulation of cell migration;GO:0051897|positive regulation of protein kinase B signaling;GO:0061098|positive regulation of protein tyrosine kinase activity;GO:0090527|actin filament reorganization;GO:1900026|positive regulation of substrate adhesion-dependent cell spreading;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005925|focal adhesion;","GO:1990782|protein tyrosine kinase binding;",".","."]
["ENSRNOG00000015774",59,4.96398085,26,1.672591393,2.967838332,1.569412506,{"v":1.33E-6,"d":"1.33E-06"},{"v":1.54e-06,"d":"1.54E-06"},"up","yes","Mreg","protein_coding","chr9:73787267-73842087:-","gi|564369136|ref|XP_006245327.1|",963,{"v":2e-122,"d":"2.00E-122"},"PREDICTED: melanoregulin isoform X1 [Rattus norvegicus]","gi|672065807|ref|XM_006245265.2|",1943,0,"PREDICTED: Rattus norvegicus melanoregulin (Mreg), transcript variant X1, mRNA","Q6NVG5",337,{"v":3e-109,"d":"3.00E-109"},"Melanoregulin",".",".",".",".","pfam05110","AF-4","AF-4 proto-oncoprotein. This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.","GO:0030318|melanocyte differentiation;GO:0032400|melanosome localization;GO:0032402|melanosome transport;GO:0043473|pigmentation;GO:0048066|developmental pigmentation;GO:0072385|minus-end-directed organelle transport along microtubule;GO:0090382|phagosome maturation;","GO:0030659|cytoplasmic vesicle membrane;GO:0031300|intrinsic component of organelle membrane;GO:0031902|late endosome membrane;GO:0032991|protein-containing complex;GO:0033162|melanosome membrane;GO:0042470|melanosome;","GO:0035091|phosphatidylinositol binding;",".","."]
["ENSRNOG00000005565",51,4.290898701,20,1.286608764,3.335045448,1.737706422,{"v":1.33E-6,"d":"1.33E-06"},{"v":1.54e-06,"d":"1.54E-06"},"up","yes","Traf3ip3","protein_coding","chr13:104694805-104719673:-","gi|672075176|ref|XP_008768087.1|",2500,0,"PREDICTED: TRAF3-interacting JNK-activating modulator isoform X1 [Rattus norvegicus]","gi|672075175|ref|XM_008769865.1|",2465,0,"PREDICTED: Rattus norvegicus TRAF3 interacting protein 3 (Traf3ip3), transcript variant X1, mRNA","Q8C0G2",752,0,"TRAF3-interacting JNK-activating modulator",".",".",".",".","pfam07888","CALCOCO1","Calcium binding and coiled-coil domain (CALCOCO1) like. Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.",".",".",".",".","."]
["ENSRNOG00000027096",105,8.834203208,65,4.181478482,2.112698474,1.079086879,{"v":1.37E-6,"d":"1.37E-06"},{"v":1.59E-6,"d":"1.59E-06"},"up","yes","Ctsw","protein_coding","chr1:202772572-202775964:-","gi|66730453|ref|NP_001019413.1|",1827,0,"cathepsin W precursor [Rattus norvegicus]","gi|66730452|ref|NM_001024242.1|",1245,0,"Rattus norvegicus cathepsin W (Ctsw), mRNA","P56203",611,0,"Cathepsin W","MA3430_1",57.8,{"v":3e-08,"d":"3.00E-08"},"COG4870","pfam00112","Peptidase_C1","Papain family cysteine protease.","GO:0051603|proteolysis involved in cellular protein catabolic process;","GO:0005615|extracellular space;GO:0005764|lysosome;","GO:0004197|cysteine-type endopeptidase activity;","K08569","CTSW; cathepsin W [EC:3.4.22.-]"]
["ENSRNOG00000003722",82,6.899092029,45,2.894869718,2.383213305,1.252908083,{"v":1.53E-6,"d":"1.53E-06"},{"v":1.76e-06,"d":"1.76E-06"},"up","yes","Dusp27","protein_coding","chr13:78349365-78378458:-","gi|300794139|ref|NP_001178858.1|",4689,0,"inactive dual specificity phosphatase 27 [Rattus norvegicus]","gi|672074526|ref|XM_006250187.2|",4036,0,"PREDICTED: Rattus norvegicus dual specificity phosphatase 27 (putative) (Dusp27), transcript variant X2, mRNA","Q148W8",1659,0,"Inactive dual specificity phosphatase 27","SPBC17A3.06",70.5,{"v":6e-12,"d":"6.00E-12"},"COG2453","pfam00782","DSPc","Dual specificity phosphatase, catalytic domain. Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a \"recognition\" region.","GO:0006470|protein dephosphorylation;GO:0043409|negative regulation of MAPK cascade;","GO:0005737|cytoplasm;","GO:0008138|protein tyrosine/serine/threonine phosphatase activity;GO:0033549|MAP kinase phosphatase activity;","K14165","K14165; atypical dual specificity phosphatase [EC:3.1.3.16 3.1.3.48]"]
["ENSRNOG00000033520",56,4.711575044,24,1.543930516,3.051675574,1.609601596,{"v":1.6e-06,"d":"1.60E-06"},{"v":1.84E-6,"d":"1.84E-06"},"up","yes","Wdr97","protein_coding","chr7:108078337-108087034:+","gi|564308945|ref|XP_006226201.1|",7611,0,"PREDICTED: WD repeat-containing protein KIAA1875-like isoform X1 [Rattus norvegicus]","gi|672022059|ref|XM_006226139.2|",5151,0,"PREDICTED: Rattus norvegicus similar to KIAA1875 protein (RGD1562063), transcript variant X1, mRNA","A6NE52",1496,0,"WD repeat-containing protein 97",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.",".",".",".",".","."]
["ENSRNOG00000070737",42,3.533681283,14,0.900626135,3.92358288,1.972171675,{"v":1.74e-06,"d":"1.74E-06"},{"v":1.99E-6,"d":"1.99E-06"},"up","yes","ENSRNOG00000070737","protein_coding","chr10:82984776-82992334:-","gi|564374390|ref|XP_006247459.1|",394,{"v":1e-39,"d":"1.00E-39"},"PREDICTED: putative ADP-ribosylation factor-like protein 5C isoform X2 [Rattus norvegicus]","gi|298893492|emb|FQ234434.1|",1123,0,"Rattus norvegicus TL0AEA59YA10 mRNA sequence","Q6P068",143,{"v":2e-36,"d":"2.00E-36"},"ADP-ribosylation factor-like protein 5C","YDL192w",78.6,{"v":8e-15,"d":"8.00E-15"},"COG1100","pfam00025","Arf","ADP-ribosylation factor family. Pfam combines a number of different Prosite families together",".",".",".",".","."]
["ENSRNOG00000009907",57,4.795710313,25,1.608260955,2.981922989,1.576242999,{"v":1.86E-6,"d":"1.86E-06"},{"v":2.12E-6,"d":"2.12E-06"},"up","yes","Mmp8","protein_coding","chr8:4724029-4733520:+","gi|149020725|gb|EDL78530.1|",2517,0,"matrix metallopeptidase 8 [Rattus norvegicus]","gi|160333380|ref|NM_008611.4|",1447,0,"Mus musculus matrix metallopeptidase 8 (Mmp8), mRNA","O88766",971,0,"Neutrophil collagenase","MA4674",50.4,{"v":4e-06,"d":"4.00E-06"},"COG5549","pfam00413","Peptidase_M10","Matrixin. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.","GO:0001503|ossification;GO:0006508|proteolysis;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0030198|extracellular matrix organization;GO:0030574|collagen catabolic process;GO:0032693|negative regulation of interleukin-10 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0035987|endodermal cell differentiation;GO:0043388|positive regulation of DNA binding;GO:0043410|positive regulation of MAPK cascade;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0046330|positive regulation of JNK cascade;GO:0150078|positive regulation of neuroinflammatory response;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1903428|positive regulation of reactive oxygen species biosynthetic process;GO:1903980|positive regulation of microglial cell activation;","GO:0005615|extracellular space;GO:0031012|extracellular matrix;","GO:0004175|endopeptidase activity;GO:0004222|metalloendopeptidase activity;GO:0004252|serine-type endopeptidase activity;GO:0005509|calcium ion binding;GO:0008233|peptidase activity;GO:0008237|metallopeptidase activity;GO:0008270|zinc ion binding;","K01402","MMP8; matrix metalloproteinase-8 (neutrophil collagenase) [EC:3.4.24.34]"]
["ENSRNOG00000015902",72,6.057739343,37,2.380226213,2.545026733,1.347680811,{"v":1.87e-06,"d":"1.87E-06"},{"v":2.14e-06,"d":"2.14E-06"},"up","yes","Cpxm2","protein_coding","chr1:186836797-186947220:-","gi|157821069|ref|NP_001099776.1|",3545,0,"inactive carboxypeptidase-like protein X2 precursor [Rattus norvegicus]","gi|157821068|ref|NM_001106306.1|",3498,0,"Rattus norvegicus carboxypeptidase X (M14 family), member 2 (Cpxm2), mRNA","Q9D2L5",1317,0,"Inactive carboxypeptidase-like protein X2",".",".",".",".","pfam00246","Peptidase_M14","Zinc carboxypeptidase.","GO:0006518|peptide metabolic process;GO:0016485|protein processing;","GO:0005615|extracellular space;","GO:0004181|metallocarboxypeptidase activity;GO:0008270|zinc ion binding;","K08639","CPXM2; carboxypeptidase X2"]
["ENSRNOG00000025597",29,2.439922791,6,0.385982629,6.321327974,2.660227669,{"v":1.97e-06,"d":"1.97E-06"},{"v":2.24e-06,"d":"2.24E-06"},"up","yes","Rnase6","protein_coding","chr15:24354303-24357328:+","gi|573014606|tpe|CDG32035.1|",723,{"v":4E-90,"d":"4.00E-90"},"TPA: ribonuclease A d1 [Rattus norvegicus]","gi|672089524|ref|XM_008773788.1|",1393,0,"PREDICTED: Rattus norvegicus ribonuclease K6-like (LOC103694852), transcript variant X2, mRNA","Q9D244",230,{"v":1e-71,"d":"1.00E-71"},"Ribonuclease K6",".",".",".",".","pfam00074","RnaseA","Pancreatic ribonuclease. Ribonucleases. Members include pancreatic RNAase A and angiogenins. Structure is an alpha+beta fold -- long curved beta sheet and three helices.","GO:0008150|biological_process;GO:0019731|antibacterial humoral response;GO:0045087|innate immune response;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:0051607|defense response to virus;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0090501|RNA phosphodiester bond hydrolysis;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0031410|cytoplasmic vesicle;","GO:0003674|molecular_function;GO:0003676|nucleic acid binding;GO:0004519|endonuclease activity;GO:0004540|ribonuclease activity;","K01172","RNASE6_7_8; ribonuclease 6/7/8 [EC:3.1.27.-]"]
["ENSRNOG00000033076",95,7.992850521,57,3.666834977,2.179768267,1.124174769,{"v":2.06e-06,"d":"2.06E-06"},{"v":2.34E-6,"d":"2.34E-06"},"up","yes","Thnsl1","protein_coding","chr17:83714738-83723805:+","gi|68163509|ref|NP_001020206.1|",4006,0,"threonine synthase-like 1 [Rattus norvegicus]","gi|68163508|ref|NM_001025035.1|",2668,0,"Rattus norvegicus threonine synthase-like 1 (Thnsl1), mRNA",".",".",".",".","L0092",336,{"v":3e-100,"d":"3.00E-100"},"COG0498","pfam01202","SKI","Shikimate kinase.","GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005737|cytoplasm;","GO:0003674|molecular_function;",".","."]
["ENSRNOG00000061595",46,3.870222358,17,1.093617449,3.538917892,1.82330829,{"v":2.06e-06,"d":"2.06E-06"},{"v":2.35e-06,"d":"2.35E-06"},"up","yes","Tfec","protein_coding","chr4:45107641-45180236:-","gi|158187526|ref|NP_071774.1|",1528,0,"transcription factor EC [Rattus norvegicus]","gi|158187525|ref|NM_022379.1|",1596,0,"Rattus norvegicus transcription factor EC (Tfec), mRNA","Q63302",593,0,"Transcription factor EC",".",".",".",".","pfam11851","DUF3371","Domain of unknown function (DUF3371). This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is typically between 125 to 142 amino acids in length.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0034605|cellular response to heat;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;GO:0005654|nucleoplasm;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0046983|protein dimerization activity;GO:1990837|sequence-specific double-stranded DNA binding;","K15591","TFEC; transcription factor EC"]
["ENSRNOG00000010898",18,1.514434836,0,0.032165219,47.08299456,5.557134176,{"v":2.15e-06,"d":"2.15E-06"},{"v":2.43E-6,"d":"2.43E-06"},"up","yes","Prok2","protein_coding","chr4:132347103-132361385:-","gi|82830397|ref|NP_001032630.1|",292,{"v":6e-28,"d":"6.00E-28"},"prokineticin-2 isoform 1 precursor [Rattus norvegicus]","gi|6524946|gb|AF182064.1|AF182064",578,0,"Mus musculus Bv8 variant 1 precursor (Bv8) mRNA, complete cds","Q8R413",115,{"v":3e-29,"d":"3.00E-29"},"Prokineticin-2",".",".",".",".","pfam06607","Prokineticin","Prokineticin. This family consists of several prokineticin proteins and related BM8 sequences. The suprachiasmatic nucleus (SCN) controls the circadian rhythm of physiological and behavioural processes in mammals. It has been shown that prokineticin 2 (PK2), a cysteine-rich secreted protein, functions as an output molecule from the SCN circadian clock. PK2 messenger RNA is rhythmically expressed in the SCN, and the phase of PK2 rhythm is responsive to light entrainment. Molecular and genetic studies have revealed that PK2 is a gene that is controlled by a circadian clock.","GO:0001525|angiogenesis;GO:0001935|endothelial cell proliferation;GO:0006935|chemotaxis;GO:0007218|neuropeptide signaling pathway;GO:0007283|spermatogenesis;GO:0007623|circadian rhythm;GO:0043066|negative regulation of apoptotic process;GO:0045987|positive regulation of smooth muscle contraction;","GO:0005576|extracellular region;","GO:0001664|G protein-coupled receptor binding;","K24191","PROK; prokineticin"]
["ENSRNOG00000016753",27,2.271652253,5,0.321652191,7.062449184,2.820168582,{"v":2.21E-6,"d":"2.21E-06"},{"v":2.5e-06,"d":"2.50E-06"},"up","yes","Slc14a1","protein_coding","chr18:71565454-71595146:-","gi|672083551|ref|XP_008770390.1|",2059,0,"PREDICTED: urea transporter 1 isoform X2 [Rattus norvegicus]","gi|672083550|ref|XM_008772168.1|",3742,0,"PREDICTED: Rattus norvegicus solute carrier family 14 (urea transporter), member 1 (Slc14a1), transcript variant X1, mRNA","P97689",679,0,"Urea transporter 1","SA2081",83.6,{"v":3e-16,"d":"3.00E-16"},"COG4413","pfam03253","UT","Urea transporter. Members of this family transport urea across membranes. The family includes a bacterial homologue, Actinobacillus pleuropneumoniae urea transport protein Utp.","GO:0006833|water transport;GO:0015840|urea transport;GO:0071918|urea transmembrane transport;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016323|basolateral plasma membrane;","GO:0005372|water transmembrane transporter activity;GO:0015204|urea transmembrane transporter activity;GO:0015265|urea channel activity;","K08716","SLC14A; solute carrier family 14 (urea transporter)"]
["ENSRNOG00000005133",50,4.206763432,20,1.286608764,3.2696524,1.70913727,{"v":2.22e-06,"d":"2.22E-06"},{"v":2.51e-06,"d":"2.51E-06"},"up","yes","Mapt","protein_coding","chr10:89138627-89236129:+","gi|672069483|ref|XP_008766494.1|",2529,0,"PREDICTED: microtubule-associated protein tau isoform X5 [Rattus norvegicus]","gi|672069482|ref|XM_008768272.1|",5655,0,"PREDICTED: Rattus norvegicus microtubule-associated protein tau (Mapt), transcript variant X5, mRNA","P19332",524,{"v":1e-162,"d":"1.00E-162"},"Microtubule-associated protein tau",".",".",".",".","pfam00418","Tubulin-binding","Tau and MAP protein, tubulin-binding repeat. This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.","GO:0000226|microtubule cytoskeleton organization;GO:0001764|neuron migration;GO:0006915|apoptotic process;GO:0007017|microtubule-based process;GO:0007409|axonogenesis;GO:0007416|synapse assembly;GO:0007420|brain development;GO:0007565|female pregnancy;GO:0007584|response to nutrient;GO:0007611|learning or memory;GO:0007613|memory;GO:0007628|adult walking behavior;GO:0008088|axo-dendritic transport;GO:0008631|intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0010033|response to organic substance;GO:0010288|response to lead ion;GO:0010506|regulation of autophagy;GO:0010629|negative regulation of gene expression;GO:0010917|negative regulation of mitochondrial membrane potential;GO:0010976|positive regulation of neuron projection development;GO:0030182|neuron differentiation;GO:0031110|regulation of microtubule polymerization or depolymerization;GO:0031116|positive regulation of microtubule polymerization;GO:0031175|neuron projection development;GO:0032387|negative regulation of intracellular transport;GO:0032930|positive regulation of superoxide anion generation;GO:0033673|negative regulation of kinase activity;GO:0045773|positive regulation of axon extension;GO:0046785|microtubule polymerization;GO:0047497|mitochondrion transport along microtubule;GO:0048312|intracellular distribution of mitochondria;GO:0048675|axon extension;GO:0050808|synapse organization;GO:0050848|regulation of calcium-mediated signaling;GO:0051028|mRNA transport;GO:0051258|protein polymerization;GO:0051260|protein homooligomerization;GO:0060632|regulation of microtubule-based movement;GO:0070507|regulation of microtubule cytoskeleton organization;GO:0090258|negative regulation of mitochondrial fission;GO:0097435|supramolecular fiber organization;GO:1900034|regulation of cellular response to heat;GO:1900454|positive regulation of long-term synaptic depression;GO:1901216|positive regulation of neuron death;GO:1902474|positive regulation of protein localization to synapse;GO:1903748|negative regulation of establishment of protein localization to mitochondrion;GO:1903829|positive regulation of cellular protein localization;GO:1904428|negative regulation of tubulin deacetylation;GO:1990000|amyloid fibril formation;GO:2001020|regulation of response to DNA damage stimulus;","GO:0005576|extracellular region;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005874|microtubule;GO:0005886|plasma membrane;GO:0005930|axoneme;GO:0009898|cytoplasmic side of plasma membrane;GO:0014069|postsynaptic density;GO:0015630|microtubule cytoskeleton;GO:0016020|membrane;GO:0016607|nuclear speck;GO:0030424|axon;GO:0030425|dendrite;GO:0030426|growth cone;GO:0030673|axolemma;GO:0034399|nuclear periphery;GO:0036464|cytoplasmic ribonucleoprotein granule;GO:0036477|somatodendritic compartment;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0044295|axonal growth cone;GO:0044297|cell body;GO:0044304|main axon;GO:0045121|membrane raft;GO:0045298|tubulin complex;GO:0097386|glial cell projection;GO:0097418|neurofibrillary tangle;","GO:0003677|DNA binding;GO:0005515|protein binding;GO:0008017|microtubule binding;GO:0017124|SH3 domain binding;GO:0019899|enzyme binding;GO:0019901|protein kinase binding;GO:0031072|heat shock protein binding;GO:0034185|apolipoprotein binding;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;GO:0051087|chaperone binding;GO:0051721|protein phosphatase 2A binding;GO:0051879|Hsp90 protein binding;GO:0071813|lipoprotein particle binding;GO:0099609|microtubule lateral binding;","K04380","MAPT, TAU; microtubule-associated protein tau"]
["ENSRNOG00000005810",50,4.206763432,20,1.286608764,3.2696524,1.70913727,{"v":2.22e-06,"d":"2.22E-06"},{"v":2.51e-06,"d":"2.51E-06"},"up","yes","Nlrc4","protein_coding","chr6:20995266-21018248:+","gi|827012496|ref|NP_001296361.1|",5285,0,"NLR family CARD domain-containing protein 4 [Rattus norvegicus]","gi|827012495|ref|NM_001309432.1|",3441,0,"Rattus norvegicus NLR family, CARD domain containing 4 (Nlrc4), mRNA","F1M649",2040,0,"NLR family CARD domain-containing protein 4",".",".",".",".","pfam05729","NACHT","NACHT domain. This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.","GO:0002218|activation of innate immune response;GO:0006915|apoptotic process;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006954|inflammatory response;GO:0010954|positive regulation of protein processing;GO:0016045|detection of bacterium;GO:0032731|positive regulation of interleukin-1 beta production;GO:0042742|defense response to bacterium;GO:0042981|regulation of apoptotic process;GO:0043065|positive regulation of apoptotic process;GO:0043281|regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045087|innate immune response;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051260|protein homooligomerization;GO:0070269|pyroptosis;GO:0097202|activation of cysteine-type endopeptidase activity;","GO:0005829|cytosol;GO:0072557|IPAF inflammasome complex;","GO:0005524|ATP binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0061133|endopeptidase activator activity;GO:0089720|caspase binding;","K12805","NLRC4, CARD12; NLR family CARD domain-containing protein 4"]
["ENSRNOG00000066588",37,3.11300494,11,0.70763482,4.399168684,2.137230922,{"v":2.29e-06,"d":"2.29E-06"},{"v":2.58e-06,"d":"2.58E-06"},"up","yes","ENSRNOG00000066588","lncRNA","chr11:30683524-30696037:+","gi|149062621|gb|EDM13044.1|",139,{"v":2e-06,"d":"2.00E-06"},"rCG63645 [Rattus norvegicus]","gi|49615110|gb|AC120974.7|",8590,0,"Rattus norvegicus 11 BAC CH230-358O2 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam05030","SSXT","SSXT protein (N-terminal region). The SSXT or SS18 protein is involved in synovial sarcoma in humans. A SYT-SSX fusion gene resulting from the chromosomal translocation t(X;18) (p11;q11) is characteristic of synovial sarcomas. This translocation fuses the SSXT (SYT) gene from chromosome 18 to either of two homologous genes at Xp11, SSX1 or SSX2.",".",".",".",".","."]
["ENSRNOG00000031202",23,1.935111179,3,0.192991315,10.02693403,3.32580863,{"v":2.37e-06,"d":"2.37E-06"},{"v":2.67e-06,"d":"2.67E-06"},"up","yes","Trim30c","protein_coding","chr1:158765969-158787183:-","gi|564298115|ref|XP_006223500.1|",2667,0,"PREDICTED: tripartite motif-containing protein 30A-like [Rattus norvegicus]","gi|672014100|ref|XM_006223438.2|",1853,0,"PREDICTED: Rattus norvegicus tripartite motif-containing protein 30A-like (LOC102554102), transcript variant X1, mRNA","P15533",682,0,"Tripartite motif-containing protein 30A",".",".",".",".","pfam00097","zf-C3HC4","Zinc finger, C3HC4 type (RING finger). The C3HC4 type zinc-finger (RING finger) is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C where X is any amino acid. Many proteins containing a RING finger play a key role in the ubiquitination pathway.",".",".","GO:0008270|zinc ion binding;",".","."]
["ENSRNOG00000010663",75,6.310145148,40,2.573217527,2.4522393,1.29409977,{"v":2.41e-06,"d":"2.41E-06"},{"v":2.71e-06,"d":"2.71E-06"},"up","yes","Col6a5","protein_coding","chr8:106483799-106584113:-","gi|672023518|ref|XP_008756121.1|",7881,0,"PREDICTED: collagen alpha-5(VI) chain isoform X1 [Rattus norvegicus]","gi|672063277|ref|XM_008766594.1|",8447,0,"PREDICTED: Rattus norvegicus collagen, type VI, alpha 5 (Col6a5), transcript variant X2, mRNA","A6H584",2737,0,"Collagen alpha-5(VI) chain",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0030198|extracellular matrix organization;","GO:0005576|extracellular region;GO:0031012|extracellular matrix;",".","K06238","COL6A; collagen type VI alpha"]
["ENSRNOG00000016910",99,8.329391596,61,3.924156729,2.122594017,1.085828457,{"v":2.45e-06,"d":"2.45E-06"},{"v":2.75e-06,"d":"2.75E-06"},"up","yes","Ralgps1","protein_coding","chr3:16433742-16669972:-","gi|148676648|gb|EDL08595.1|",2927,0,"Ral GEF with PH domain and SH3 binding motif 1, isoform CRA_c, partial [Mus musculus]","gi|672016612|ref|XM_006224358.2|",2533,0,"PREDICTED: Rattus norvegicus Ral GEF with PH domain and SH3 binding motif 1 (Ralgps1), transcript variant X2, mRNA","A2AR50",1063,0,"Ras-specific guanine nucleotide-releasing factor RalGPS1",".",".",".",".","pfam00617","RasGEF","RasGEF domain. Guanine nucleotide exchange factor for Ras-like small GTPases.","GO:0007264|small GTPase mediated signal transduction;GO:0032485|regulation of Ral protein signal transduction;GO:0050790|regulation of catalytic activity;",".","GO:0005085|guanyl-nucleotide exchange factor activity;","K24023","RALGPS; Ras-specific guanine nucleotide-releasing factor RalGPS"]
["ENSRNOG00000009892",90,7.572174178,53,3.409513224,2.22089597,1.151141816,{"v":2.48E-6,"d":"2.48E-06"},{"v":2.78e-06,"d":"2.78E-06"},"up","yes","Adamts15","protein_coding","chr8:29307865-29331249:-","gi|157819065|ref|NP_001100280.1|",4986,0,"A disintegrin and metalloproteinase with thrombospondin motifs 15 precursor [Rattus norvegicus]","gi|157819064|ref|NM_001106810.1|",6064,0,"Rattus norvegicus ADAM metallopeptidase with thrombospondin type 1 motif, 15 (Adamts15), mRNA","P59384",1909,0,"A disintegrin and metalloproteinase with thrombospondin motifs 15",".",".",".",".","pfam05986","ADAM_spacer1","ADAM-TS Spacer 1. This family represents the Spacer-1 region from the ADAM-TS family of metalloproteinases.","GO:0006508|proteolysis;GO:0007229|integrin-mediated signaling pathway;GO:0007520|myoblast fusion;GO:0022617|extracellular matrix disassembly;GO:0030198|extracellular matrix organization;","GO:0005615|extracellular space;GO:0009986|cell surface;GO:0031012|extracellular matrix;GO:0062023|collagen-containing extracellular matrix;","GO:0004175|endopeptidase activity;GO:0004222|metalloendopeptidase activity;GO:0008201|heparin binding;GO:0008270|zinc ion binding;GO:0050840|extracellular matrix binding;","K08629","ADAMTS15; a disintegrin and metalloproteinase with thrombospondin motifs 15 [EC:3.4.24.-]"]
["ENSRNOG00000019961",64,5.384657193,31,1.994243584,2.700100047,1.433012864,{"v":2.49e-06,"d":"2.49E-06"},{"v":2.8e-06,"d":"2.80E-06"},"up","yes","Tcte1","protein_coding","chr9:15455801-15464302:+","gi|85701444|ref|NP_001013771.1|",2324,0,"transmembrane protein 151B [Mus musculus]","gi|51260230|gb|BC079879.1|",2716,0,"Mus musculus transmembrane protein 151B, mRNA (cDNA clone MGC:105223 IMAGE:6852149), complete cds","Q68FE7",899,0,"Transmembrane protein 151B",".",".",".",".","pfam14857","TMEM151","TMEM151 family. This family of proteins is found in eukaryotes. Proteins in this family are typically between 338 and 558 amino acids in length.","GO:0030317|flagellated sperm motility;","GO:0036126|sperm flagellum;",".","K25450","TCTE1, DRC5; dynein regulatory complex subunit 5"]
["ENSRNOG00000024433",112,9.423150088,73,4.696121987,2.006581199,1.004739538,{"v":2.55e-06,"d":"2.55E-06"},{"v":2.86e-06,"d":"2.86E-06"},"up","yes","Fbxl7","protein_coding","chr2:77140826-77509223:-","gi|37360118|dbj|BAC98037.1|",2610,0,"mKIAA0840 protein [Mus musculus]","gi|157818662|ref|NM_001108545.1|",3473,0,"Rattus norvegicus F-box and leucine-rich repeat protein 7 (Fbxl7), mRNA","Q5BJ29",962,0,"F-box/LRR-repeat protein 7",".",".",".",".","pfam12937","F-box-like","F-box-like. This is an F-box-like family.","GO:0000086|G2/M transition of mitotic cell cycle;GO:0000209|protein polyubiquitination;GO:0000278|mitotic cell cycle;GO:0016567|protein ubiquitination;GO:0031146|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;","GO:0005813|centrosome;GO:0019005|SCF ubiquitin ligase complex;",".","K10273","FBXL7; F-box and leucine-rich repeat protein 7"]
["ENSRNOG00000061238",86,7.235633104,50,3.216521909,2.249520851,1.16961774,{"v":3.12e-06,"d":"3.12E-06"},{"v":3.47e-06,"d":"3.47E-06"},"up","yes","Wnt10b","protein_coding","chr7:129922088-129927892:-","gi|532078357|ref|XP_005324955.1|",1805,0,"PREDICTED: protein Wnt-10b [Ictidomys tridecemlineatus]","gi|157821972|ref|NM_001108111.1|",2231,0,"Rattus norvegicus wingless-type MMTV integration site family, member 10B (Wnt10b), mRNA","O00744",672,0,"Protein Wnt-10b",".",".",".",".","pfam00110","wnt","wnt family. Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.","GO:0000086|G2/M transition of mitotic cell cycle;GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0002062|chondrocyte differentiation;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006629|lipid metabolic process;GO:0007224|smoothened signaling pathway;GO:0008284|positive regulation of cell proliferation;GO:0010971|positive regulation of G2/M transition of mitotic cell cycle;GO:0014835|myoblast differentiation involved in skeletal muscle regeneration;GO:0016055|Wnt signaling pathway;GO:0030182|neuron differentiation;GO:0030501|positive regulation of bone mineralization;GO:0030858|positive regulation of epithelial cell differentiation;GO:0032434|regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0043065|positive regulation of apoptotic process;GO:0043403|skeletal muscle tissue regeneration;GO:0045165|cell fate commitment;GO:0045598|regulation of fat cell differentiation;GO:0045599|negative regulation of fat cell differentiation;GO:0045669|positive regulation of osteoblast differentiation;GO:0045778|positive regulation of ossification;GO:0045899|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048641|regulation of skeletal muscle tissue development;GO:0048741|skeletal muscle fiber development;GO:0050680|negative regulation of epithelial cell proliferation;GO:0050821|protein stabilization;GO:0050909|sensory perception of taste;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051246|regulation of protein metabolic process;GO:0051726|regulation of cell cycle;GO:0051885|positive regulation of timing of anagen;GO:0060070|canonical Wnt signaling pathway;GO:0060346|bone trabecula formation;GO:0061196|fungiform papilla development;GO:0071310|cellular response to organic substance;GO:0071320|cellular response to cAMP;GO:0071374|cellular response to parathyroid hormone stimulus;GO:0071407|cellular response to organic cyclic compound;GO:0071425|hematopoietic stem cell proliferation;GO:0071464|cellular response to hydrostatic pressure;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:0120163|negative regulation of cold-induced thermogenesis;","GO:0005575|cellular_component;GO:0005615|extracellular space;","GO:0003674|molecular_function;GO:0005109|frizzled binding;GO:0005125|cytokine activity;","K01357","WNT10; wingless-type MMTV integration site family, member 10"]
["ENSRNOG00000067848",30,2.524058059,7,0.450313067,5.6051184,2.486744848,{"v":3.15e-06,"d":"3.15E-06"},{"v":3.5e-06,"d":"3.50E-06"},"up","yes","Clec4d","protein_coding","chr4:156589792-156598848:+","gi|149049513|gb|EDM01967.1|",965,{"v":9e-129,"d":"9.00E-129"},"rCG29628 [Rattus norvegicus]","gi|672050889|ref|XM_006237322.2|",552,0,"PREDICTED: Rattus norvegicus C-type lectin domain family 4, member D (Clec4d), transcript variant X1, mRNA","Q69FH1",371,{"v":2e-128,"d":"2.00E-128"},"C-type lectin domain family 4 member D",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type",".",".",".",".","."]
["ENSRNOG00000042229",107,9.002473745,69,4.438800235,2.028132213,1.020151704,{"v":3.23E-6,"d":"3.23E-06"},{"v":3.58E-6,"d":"3.58E-06"},"up","yes","Gimap1","protein_coding","chr4:77682171-77691866:+","gi|77680743|emb|CAG17876.1|",1577,0,"Ian2 protein [Rattus norvegicus]","gi|298906633|emb|FQ225168.1|",1154,0,"Rattus norvegicus TL0AEA54YO15 mRNA sequence","P70224",465,{"v":2e-154,"d":"2.00E-154"},"GTPase IMAP family member 1",".",".",".",".","pfam04548","AIG1","AIG1 family. Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.","GO:0030183|B cell differentiation;GO:0030217|T cell differentiation;","GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;","GO:0005525|GTP binding;",".","."]
["ENSRNOG00000004647",109,9.170744282,71,4.567461111,2.007842882,1.00564638,{"v":3.42e-06,"d":"3.42E-06"},{"v":3.78e-06,"d":"3.78E-06"},"up","yes","Il10","protein_coding","chr13:42472839-42477313:+","gi|148747382|ref|NP_036986.2|",910,{"v":7e-119,"d":"7.00E-119"},"interleukin-10 precursor [Rattus norvegicus]","gi|296620|emb|X60675.1|",1274,0,"R.norvegicus mRNA for interleukin 10","P29456",355,{"v":2E-120,"d":"2.00E-120"},"Interleukin-10",".",".",".",".","pfam00726","IL10","Interleukin 10.","GO:0001818|negative regulation of cytokine production;GO:0001819|positive regulation of cytokine production;GO:0001938|positive regulation of endothelial cell proliferation;GO:0002237|response to molecule of bacterial origin;GO:0002639|positive regulation of immunoglobulin production;GO:0002719|negative regulation of cytokine production involved in immune response;GO:0002875|negative regulation of chronic inflammatory response to antigenic stimulus;GO:0002904|positive regulation of B cell apoptotic process;GO:0006955|immune response;GO:0007165|signal transduction;GO:0007568|aging;GO:0008285|negative regulation of cell proliferation;GO:0009410|response to xenobiotic stimulus;GO:0010033|response to organic substance;GO:0010468|regulation of gene expression;GO:0010507|negative regulation of autophagy;GO:0014823|response to activity;GO:0014854|response to inactivity;GO:0030886|negative regulation of myeloid dendritic cell activation;GO:0030889|negative regulation of B cell proliferation;GO:0032496|response to lipopolysaccharide;GO:0032689|negative regulation of interferon-gamma production;GO:0032695|negative regulation of interleukin-12 production;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032868|response to insulin;GO:0034115|negative regulation of heterotypic cell-cell adhesion;GO:0034465|response to carbon monoxide;GO:0035729|cellular response to hepatocyte growth factor stimulus;GO:0042742|defense response to bacterium;GO:0042832|defense response to protozoan;GO:0043032|positive regulation of macrophage activation;GO:0043066|negative regulation of apoptotic process;GO:0043524|negative regulation of neuron apoptotic process;GO:0045019|negative regulation of nitric oxide biosynthetic process;GO:0045347|negative regulation of MHC class II biosynthetic process;GO:0045348|positive regulation of MHC class II biosynthetic process;GO:0045787|positive regulation of cell cycle;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046427|positive regulation of JAK-STAT cascade;GO:0050728|negative regulation of inflammatory response;GO:0050807|regulation of synapse organization;GO:0051045|negative regulation of membrane protein ectodomain proteolysis;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051384|response to glucocorticoid;GO:0051930|regulation of sensory perception of pain;GO:0060302|negative regulation of cytokine activity;GO:0060670|branching involved in labyrinthine layer morphogenesis;GO:0071222|cellular response to lipopolysaccharide;GO:0071392|cellular response to estradiol stimulus;GO:0097421|liver regeneration;GO:1900100|positive regulation of plasma cell differentiation;GO:1902895|positive regulation of pri-miRNA transcription by RNA polymerase II;GO:1903034|regulation of response to wounding;GO:1903208|negative regulation of hydrogen peroxide-induced neuron death;GO:1903672|positive regulation of sprouting angiogenesis;GO:1904057|negative regulation of sensory perception of pain;GO:1904706|negative regulation of vascular smooth muscle cell proliferation;GO:2000273|positive regulation of signaling receptor activity;GO:2000352|negative regulation of endothelial cell apoptotic process;","GO:0005615|extracellular space;","GO:0005125|cytokine activity;GO:0005141|interleukin-10 receptor binding;GO:0046983|protein dimerization activity;","K05443","IL10, CSIF; interleukin 10"]
["ENSRNOG00000043478",39,3.281275477,13,0.836295696,3.92358288,1.972171675,{"v":4.08e-06,"d":"4.08E-06"},{"v":4.47e-06,"d":"4.47E-06"},"up","yes","AABR07006142.1","protein_coding","chr2:85011149-85049805:+","gi|672073888|ref|XP_008767726.1|",1306,{"v":2E-176,"d":"2.00E-176"},"PREDICTED: tyrosine-protein phosphatase non-receptor type substrate 1-like isoform X2 [Rattus norvegicus]","gi|672073889|ref|XM_003751228.3|",818,0,"PREDICTED: Rattus norvegicus tyrosine-protein phosphatase non-receptor type substrate 1-like (LOC100909964), transcript variant X3, mRNA","P97797",188,{"v":7e-52,"d":"7.00E-52"},"Tyrosine-protein phosphatase non-receptor type substrate 1",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000064957",36,3.028869671,11,0.70763482,4.280272233,2.097702558,{"v":4.08e-06,"d":"4.08E-06"},{"v":4.48e-06,"d":"4.48E-06"},"up","yes","Ly49si3","protein_coding","chr4:163480531-163503985:-","gi|57222324|ref|NP_001009498.1|",1227,{"v":8E-167,"d":"8.00E-167"},"immunoreceptor Ly49si2 [Rattus norvegicus]","gi|672051477|ref|XM_008763413.1|",906,0,"PREDICTED: Rattus norvegicus immunoreceptor Ly49si3 (Ly49si3), transcript variant X5, mRNA","P20937",268,{"v":2e-86,"d":"2.00E-86"},"T-cell surface glycoprotein YE1/48",".",".",".",".","pfam08391","Ly49","Ly49-like protein, N-terminal region. The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).",".",".",".",".","."]
["ENSRNOG00000003136",46,3.870222358,18,1.157947887,3.342311342,1.740846129,{"v":4.27e-06,"d":"4.27E-06"},{"v":4.68e-06,"d":"4.68E-06"},"up","yes","Fcrla","protein_coding","chr13:83160398-83170762:-","gi|209915619|ref|NP_001094152.1|",1566,0,"Fc receptor-like A precursor [Rattus norvegicus]","gi|77748042|gb|BC105902.1|",1155,0,"Rattus norvegicus Fc receptor-like A, mRNA (cDNA clone IMAGE:7376173), partial cds","Q3B8P2",607,0,"Fc receptor-like A",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0007166|cell surface receptor signaling pathway;GO:0030154|cell differentiation;","GO:0005737|cytoplasm;GO:0005887|integral component of plasma membrane;","GO:0004888|transmembrane signaling receptor activity;",".","."]
["ENSRNOG00000032261",104,8.750067939,67,4.310139358,2.030112535,1.021559702,{"v":4.32e-06,"d":"4.32E-06"},{"v":4.73e-06,"d":"4.73E-06"},"up","yes","Cyp2d4","protein_coding","chr7:113881618-113891759:-","gi|19924041|ref|NP_612524.1|",2579,0,"cytochrome P450, family 2, subfamily d, polypeptide 4 [Rattus norvegicus]","gi|62471443|gb|BC093609.1|",2739,0,"Rattus norvegicus cytochrome P450, family 2, subfamily d, polypeptide 4, mRNA (cDNA clone MGC:105324 IMAGE:7319137), complete cds","Q64680",998,0,"Cytochrome P450 2D4","BH0579",100,{"v":3e-21,"d":"3.00E-21"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0006082|organic acid metabolic process;GO:0006587|serotonin biosynthetic process from tryptophan;GO:0006805|xenobiotic metabolic process;GO:0007565|female pregnancy;GO:0008202|steroid metabolic process;GO:0008207|C21-steroid hormone metabolic process;GO:0008210|estrogen metabolic process;GO:0009804|coumarin metabolic process;GO:0009820|alkaloid metabolic process;GO:0009822|alkaloid catabolic process;GO:0010033|response to organic substance;GO:0016098|monoterpenoid metabolic process;GO:0019369|arachidonic acid metabolic process;GO:0033076|isoquinoline alkaloid metabolic process;GO:0042178|xenobiotic catabolic process;GO:0042416|dopamine biosynthetic process;GO:0042417|dopamine metabolic process;GO:0042572|retinol metabolic process;GO:0046483|heterocycle metabolic process;GO:0051100|negative regulation of binding;GO:0070989|oxidative demethylation;GO:0090350|negative regulation of cellular organofluorine metabolic process;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005789|endoplasmic reticulum membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0004497|monooxygenase activity;GO:0005506|iron ion binding;GO:0008391|arachidonic acid monooxygenase activity;GO:0008395|steroid hydroxylase activity;GO:0016491|oxidoreductase activity;GO:0016712|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0020037|heme binding;GO:0070330|aromatase activity;","K07414","CYP2D; cytochrome P450 family 2 subfamily D [EC:1.14.14.1]"]
["ENSRNOG00000008865",20,1.682705373,2,0.128660876,13.0786096,3.70913727,{"v":4.38e-06,"d":"4.38E-06"},{"v":4.78E-6,"d":"4.78E-06"},"up","yes","Stac","protein_coding","chr8:111530800-111654008:-","gi|293349510|ref|XP_001076458.2|",1901,0,"PREDICTED: SH3 and cysteine-rich domain-containing protein [Rattus norvegicus]","gi|672023369|ref|XM_001076458.5|",2689,0,"PREDICTED: Rattus norvegicus SH3 and cysteine rich domain (Stac), mRNA","P97306",717,0,"SH3 and cysteine-rich domain-containing protein",".",".",".",".","pfam14604","SH3_9","Variant SH3 domain.","GO:0003009|skeletal muscle contraction;GO:0006936|muscle contraction;GO:0034605|cellular response to heat;GO:0035556|intracellular signal transduction;GO:1901385|regulation of voltage-gated calcium channel activity;GO:1901387|positive regulation of voltage-gated calcium channel activity;GO:1903078|positive regulation of protein localization to plasma membrane;GO:2001259|positive regulation of cation channel activity;","GO:0030315|T-tubule;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;","GO:0044325|ion channel binding;","K23711","STAC; SH3 and cysteine-rich domain-containing protein"]
["ENSRNOG00000024330",20,1.682705373,2,0.128660876,13.0786096,3.70913727,{"v":4.38e-06,"d":"4.38E-06"},{"v":4.78E-6,"d":"4.78E-06"},"up","yes","Ngp","protein_coding","chr8:110394203-110397570:+","gi|157821823|ref|NP_001100332.1|",779,{"v":3e-100,"d":"3.00E-100"},"neutrophilic granule protein precursor [Rattus norvegicus]","gi|157821822|ref|NM_001106862.1|",1099,0,"Rattus norvegicus neutrophilic granule protein (Ngp), mRNA","O08692",214,{"v":1e-66,"d":"1.00E-66"},"Neutrophilic granule protein",".",".",".",".","pfam00666","Cathelicidins","Cathelicidin. A novel protein family, showing a conserved proregion and a variable carboxyl-terminal antimicrobial domain. This region shows similarity to cystatins.","GO:0006952|defense response;GO:0010951|negative regulation of endopeptidase activity;","GO:0005615|extracellular space;","GO:0004869|cysteine-type endopeptidase inhibitor activity;",".","."]
["ENSRNOG00000042628",20,1.682705373,2,0.128660876,13.0786096,3.70913727,{"v":4.38e-06,"d":"4.38E-06"},{"v":4.78E-6,"d":"4.78E-06"},"up","yes","Tmem273","protein_coding","chr16:8049669-8081981:+","gi|149034139|gb|EDL88909.1|",490,{"v":1e-57,"d":"1.00E-57"},"similar to novel protein (predicted), isoform CRA_b [Rattus norvegicus]","gi|254692852|ref|NM_001134605.2|",1076,0,"Rattus norvegicus similar to novel protein (RGD1561145), mRNA",".",".",".",".",".",".",".",".","pfam14986","DUF4514","Domain of unknown function (DUF4514). This family of uncharacterized proteins are found in mammals.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000059073",20,1.682705373,2,0.128660876,13.0786096,3.70913727,{"v":4.38e-06,"d":"4.38E-06"},{"v":4.78E-6,"d":"4.78E-06"},"up","yes","Slamf1","protein_coding","chr13:84270316-84305497:+","gi|157818637|ref|NP_001102548.1|",1766,0,"signaling lymphocytic activation molecule precursor [Rattus norvegicus]","gi|157818636|ref|NM_001109078.1|",2731,0,"Rattus norvegicus signaling lymphocytic activation molecule family member 1 (Slamf1), mRNA","Q9QUM4",540,0,"Signaling lymphocytic activation molecule",".",".",".",".","pfam06214","SLAM","Signaling lymphocytic activation molecule (SLAM) protein. This family consists of several mammalian signaling lymphocytic activation molecule (SLAM) proteins. Optimal T cell activation and expansion require engagement of the TCR plus co-stimulatory signals delivered through accessory molecules. SLAM, a 70-kDa co-stimulatory molecule belonging to the Ig superfamily, is defined as a human cell surface molecule that mediates CD28-independent proliferation of human T cells and IFN-gamma production by human Th1 and Th2 clones. SLAM has also been recognized as a receptor for measles virus.","GO:0001779|natural killer cell differentiation;GO:0001787|natural killer cell proliferation;GO:0002232|leukocyte chemotaxis involved in inflammatory response;GO:0002277|myeloid dendritic cell activation involved in immune response;GO:0002725|negative regulation of T cell cytokine production;GO:0010759|positive regulation of macrophage chemotaxis;GO:0031338|regulation of vesicle fusion;GO:0032689|negative regulation of interferon-gamma production;GO:0032695|negative regulation of interleukin-12 production;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032729|positive regulation of interferon-gamma production;GO:0042104|positive regulation of activated T cell proliferation;GO:0046330|positive regulation of JNK cascade;GO:0050790|regulation of catalytic activity;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:2000349|negative regulation of CD40 signaling pathway;GO:2000510|positive regulation of dendritic cell chemotaxis;GO:2000556|positive regulation of T-helper 1 cell cytokine production;","GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0045335|phagocytic vesicle;","GO:0038023|signaling receptor activity;GO:0042169|SH2 domain binding;GO:0042802|identical protein binding;","K06536","SLAMF1, CD150; signaling lymphocytic activation molecule family member 1"]
["ENSRNOG00000064111",20,1.682705373,2,0.128660876,13.0786096,3.70913727,{"v":4.38e-06,"d":"4.38E-06"},{"v":4.78E-6,"d":"4.78E-06"},"up","yes","Tnip3","protein_coding","chr4:94811097-94907605:+","gi|564303852|ref|XP_006225013.1|",1328,{"v":1E-180,"d":"1.00E-180"},"PREDICTED: TNFAIP3-interacting protein 3 isoform X1 [Rattus norvegicus]","gi|672018389|ref|XM_006224951.2|",1309,0,"PREDICTED: Rattus norvegicus TNFAIP3 interacting protein 3 (Tnip3), transcript variant X1, mRNA","Q96KP6",155,{"v":9e-42,"d":"9.00E-42"},"TNFAIP3-interacting protein 3",".",".",".",".","pfam15619","Lebercilin","Ciliary protein causing Leber congenital amaurosis disease. Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.",".",".",".",".","."]
["ENSRNOG00000014156",22,1.85097591,3,0.192991315,9.590980374,3.261678293,{"v":4.72e-06,"d":"4.72E-06"},{"v":5.13E-6,"d":"5.13E-06"},"up","yes","Fut7","protein_coding","chr3:8239384-8242260:+","gi|41054896|ref|NP_955785.1|",1882,0,"alpha-(1,3)-fucosyltransferase 7 [Rattus norvegicus]","gi|41054895|ref|NM_199491.1|",2005,0,"Rattus norvegicus fucosyltransferase 7 (alpha (1,3) fucosyltransferase) (Fut7), mRNA","Q11131",661,0,"Alpha-(1,3)-fucosyltransferase 7",".",".",".",".","pfam00852","Glyco_transf_10","Glycosyltransferase family 10 (fucosyltransferase). This family of Fucosyltransferases are the enzymes transferring fucose from GDP-Fucose to GlcNAc in an alpha1,3 linkage. This family is know as glycosyltransferase family 10.","GO:0001807|regulation of type IV hypersensitivity;GO:0002361|CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0002522|leukocyte migration involved in immune response;GO:0002523|leukocyte migration involved in inflammatory response;GO:0006486|protein glycosylation;GO:0006672|ceramide metabolic process;GO:0006954|inflammatory response;GO:0007566|embryo implantation;GO:0022407|regulation of cell-cell adhesion;GO:0022409|positive regulation of cell-cell adhesion;GO:0036065|fucosylation;GO:0045785|positive regulation of cell adhesion;GO:0046626|regulation of insulin receptor signaling pathway;GO:0060353|regulation of cell adhesion molecule production;GO:0097021|lymphocyte migration into lymphoid organs;GO:1903037|regulation of leukocyte cell-cell adhesion;GO:1903236|regulation of leukocyte tethering or rolling;GO:1903238|positive regulation of leukocyte tethering or rolling;GO:1904994|regulation of leukocyte adhesion to vascular endothelial cell;GO:1904996|positive regulation of leukocyte adhesion to vascular endothelial cell;GO:2000389|regulation of neutrophil extravasation;","GO:0005794|Golgi apparatus;GO:0005802|trans-Golgi network;GO:0016021|integral component of membrane;GO:0032580|Golgi cisterna membrane;","GO:0008417|fucosyltransferase activity;GO:0017083|4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity;GO:0046920|alpha-(1->3)-fucosyltransferase activity;","K07635","FUT7; galactoside alpha-1,3-fucosyltransferase 7 [EC:2.4.1.-]"]
["ENSRNOG00000007455",31,2.608193328,8,0.514643505,5.06796122,2.341405485,{"v":4.77e-06,"d":"4.77E-06"},{"v":5.19e-06,"d":"5.19E-06"},"up","yes","Tmem132e","protein_coding","chr10:67330751-67386789:+","gi|672068449|ref|XP_008766187.1|",4605,0,"PREDICTED: transmembrane protein 132E isoform X1 [Rattus norvegicus]","gi|672068448|ref|XM_008767965.1|",4466,0,"PREDICTED: Rattus norvegicus transmembrane protein 132E (Tmem132e), transcript variant X1, mRNA","Q6IEE6",1345,0,"Transmembrane protein 132E",".",".",".",".","pfam06003","SMN","Survival motor neuron protein (SMN). This family consists of several eukaryotic survival motor neuron (SMN) proteins. The Survival of Motor Neurons (SMN) protein, the product of the spinal muscular atrophy-determining gene, is part of a large macromolecular complex (SMN complex) that functions in the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs). The SMN complex functions as a specificity factor essential for the efficient assembly of Sm proteins on U snRNAs and likely protects cells from illicit, and potentially deleterious, non-specific binding of Sm proteins to RNAs.","GO:0008150|biological_process;GO:0035677|posterior lateral line neuromast hair cell development;","GO:0005575|cellular_component;GO:0016021|integral component of membrane;GO:0044297|cell body;","GO:0003674|molecular_function;","K17599","TMEM132; transmembrane protein 132"]
["ENSRNOG00000037406",41,3.449546015,15,0.964956573,3.574819958,1.837870584,{"v":6.61e-06,"d":"6.61E-06"},{"v":7.07e-06,"d":"7.07E-06"},"up","yes","RGD1564171","protein_coding","chr2:175507628-175510662:+","gi|148683219|gb|EDL15166.1|",518,{"v":7e-64,"d":"7.00E-64"},"mCG146184, partial [Mus musculus]","gi|157821840|ref|NM_001109186.1|",636,0,"Rattus norvegicus RGD1564171 (RGD1564171), mRNA",".",".",".",".",".",".",".",".","pfam15104","DUF4558","Domain of unknown function (DUF4558). This family of proteins is found in eukaryotes. Proteins in this family are typically between 78 and 121 amino acids in length. One member is annotated as being a flagellar associated protein.",".",".",".",".","."]
["ENSRNOG00000051216",69,5.805333537,37,2.380226213,2.438983953,1.286280266,{"v":6.75e-06,"d":"6.75E-06"},{"v":7.21e-06,"d":"7.21E-06"},"up","yes","AABR07038983.1","lncRNA","chrX:61138374-61144585:+","gi|149042264|gb|EDL95971.1|",370,{"v":1e-37,"d":"1.00E-37"},"rCG63291 [Rattus norvegicus]","gi|30268441|emb|AL831708.9|",1620,0,"Mouse DNA sequence from clone RP23-23B17 on chromosome X, complete sequence",".",".",".",".",".",".",".",".","pfam06993","DUF1304","Protein of unknown function (DUF1304). This family consists of several hypothetical bacterial proteins of around 120 residues in length. The function of this family is unknown.",".",".",".",".","."]
["ENSRNOG00000062552",32,2.692328597,9,0.578973944,4.650172302,2.217284173,{"v":6.89e-06,"d":"6.89E-06"},{"v":7.36e-06,"d":"7.36E-06"},"up","yes","Garem1","protein_coding","chr18:12423882-12585345:-","gi|134288888|ref|NP_001028617.2|",4477,0,"GRB2-associated and regulator of MAPK protein [Mus musculus]","gi|134288887|ref|NM_001033445.2|",2711,0,"Mus musculus GRB2 associated, regulator of MAPK1 (Garem), mRNA","Q3UFT3",1731,0,"GRB2-associated and regulator of MAPK protein",".",".",".",".","pfam12736","CABIT","Cell-cycle sustaining, positive selection,. The 'CABIT' domain (for 'cysteine-containing, all- in Themis') is found in a newly identified gene family that has three mammalian homologues (Themis, Icb1 and 9130404H23Rik) that encode proteins with two CABIT domains and a highly conserved proline-rich region. In contrast, Fam59A, Fam59B and related proteins from mammals to cnidarians, including the insect Serrano proteins, have a single copy of the CABIT domain, a proline-rich region and often a C-terminal SAM (sterile-motif) domain. Multiple-sequence alignment has predicted that the CABIT domain adopts an all-strand structure with at least 12 strands, ie a dyad of six-stranded beta-barrel units. The CABIT domain contains a nearly absolutely conserved cysteine residue which is likely to be central to its function. CABIT domain proteins function downstream of tyrosine kinase signalling and interact with GRB2.",".",".",".",".","."]
["ENSRNOG00000066852",32,2.692328597,9,0.578973944,4.650172302,2.217284173,{"v":6.89e-06,"d":"6.89E-06"},{"v":7.36e-06,"d":"7.36E-06"},"up","yes","ENSRNOG00000066852","lncRNA","chr8:33524481-33527918:+","gi|148701441|gb|EDL33388.1|",227,{"v":1e-19,"d":"1.00E-19"},"mCG1045525, partial [Mus musculus]","gi|354795897|gb|JN960398.1|",168,{"v":2e-80,"d":"2.00E-80"},"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Dcps:tm1e(EUCOMM)Hmgu; transgenic",".",".",".",".",".",".",".",".","pfam11209","DUF2993","Protein of unknown function (DUF2993). This family of proteins with unknown function appears to be restricted to Cyanobacteria.",".",".",".",".","."]
["ENSRNOG00000023698",58,4.879845581,28,1.801252269,2.70914056,1.437835248,{"v":7e-06,"d":"7.00E-06"},{"v":7.47e-06,"d":"7.47E-06"},"up","yes","Tex14","protein_coding","chr10:72231801-72355805:+","gi|564313138|ref|XP_006220831.1|",7504,0,"PREDICTED: inactive serine/threonine-protein kinase TEX14 isoform X2 [Rattus norvegicus]","gi|672025071|ref|XM_006220769.2|",4742,0,"PREDICTED: Rattus norvegicus testis expressed 14 (Tex14), transcript variant X3, mRNA","F1M5M3",2850,0,"Inactive serine/threonine-protein kinase TEX14","PA3287",60.5,{"v":4e-09,"d":"4.00E-09"},"COG0666","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0006468|protein phosphorylation;GO:0007094|mitotic spindle assembly checkpoint;GO:0007140|male meiotic nuclear division;GO:0008608|attachment of spindle microtubules to kinetochore;GO:0032091|negative regulation of protein binding;GO:0032466|negative regulation of cytokinesis;GO:0043063|intercellular bridge organization;GO:0051301|cell division;GO:0051306|mitotic sister chromatid separation;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0000776|kinetochore;GO:0005737|cytoplasm;GO:0030496|midbody;GO:0045171|intercellular bridge;","GO:0004672|protein kinase activity;GO:0005524|ATP binding;GO:0019901|protein kinase binding;","K17540","TEX14, SGK307; inactive serine/threonine-protein kinase TEX14"]
["ENSRNOG00000063482",16,1.346164298,0,0.032165219,41.85155072,5.387209175,{"v":8.17e-06,"d":"8.17E-06"},{"v":8.67E-6,"d":"8.67E-06"},"up","yes","Mcpt9","protein_coding","chr15:29799357-29860148:+","gi|149064036|gb|EDM14306.1|",1293,{"v":6e-178,"d":"6.00E-178"},"rCG23443, isoform CRA_a [Rattus norvegicus]","gi|1698703|gb|U67912.1|RNU67912",777,0,"Rattus norvegicus mast cell protease 9 (RMCP-9) mRNA, partial cds","Q06606",474,{"v":2e-168,"d":"2.00E-168"},"Granzyme-like protein 2","VC1200",75.5,{"v":1E-14,"d":"1.00E-14"},"COG5640","pfam00089","Trypsin","Trypsin.",".",".",".",".","."]
["ENSRNOG00000063895",16,1.346164298,0,0.032165219,41.85155072,5.387209175,{"v":8.17e-06,"d":"8.17E-06"},{"v":8.67E-6,"d":"8.67E-06"},"up","yes","ENSRNOG00000063895","lncRNA","chr14:104865618-104870059:+",".",".",".",".","gi|77157707|gb|AC159092.11|",580,0,"Mus musculus chromosome 1, clone RP23-103C13, complete sequence",".",".",".",".",".",".",".",".","pfam15188","CCDC-167","Coiled-coil domain-containing protein 167. The function of this family of coiled-coil domains, has not, as yet, been determined. Members of this family remain uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between and 103 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000067827",16,1.346164298,0,0.032165219,41.85155072,5.387209175,{"v":8.17e-06,"d":"8.17E-06"},{"v":8.67E-6,"d":"8.67E-06"},"up","yes","Ly49i3","protein_coding","chr4:164362017-164384266:-","gi|57222330|ref|NP_001009499.1|",1513,0,"immunoreceptor Ly49i3 [Rattus norvegicus]","gi|672051460|ref|XM_008763405.1|",1115,0,"PREDICTED: Rattus norvegicus Ly49 inhibitory receptor 4 (Ly49i4), transcript variant X1, mRNA","Q60652",285,{"v":1E-91,"d":"1.00E-91"},"Killer cell lectin-like receptor 5",".",".",".",".","pfam08391","Ly49","Ly49-like protein, N-terminal region. The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).",".",".",".",".","."]
["ENSRNOG00000001342",25,2.103381716,5,0.321652191,6.5393048,2.70913727,{"v":8.2e-06,"d":"8.20E-06"},{"v":8.7e-06,"d":"8.70E-06"},"up","yes","ENSRNOG00000001342","protein_coding","chr12:33261476-33293932:-","gi|672073127|ref|XP_008767497.1|",1641,0,"PREDICTED: WD repeat-containing protein 66 isoform X2 [Rattus norvegicus]","gi|672073126|ref|XM_008769275.1|",1812,0,"PREDICTED: Rattus norvegicus WD repeat domain 66 (Wdr66), transcript variant X2, mRNA","E9Q743",596,0,"Cilia- and flagella-associated protein 251",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.","GO:0030317|flagellated sperm motility;","GO:0036126|sperm flagellum;",".","K24228","WDR66, CFAP251; cilia- and flagella-associated protein 251"]
["ENSRNOG00000013981",72,6.057739343,40,2.573217527,2.354149728,1.235206081,{"v":8.39e-06,"d":"8.39E-06"},{"v":8.88e-06,"d":"8.88E-06"},"up","yes","Ptpn5","protein_coding","chr1:97620642-97679882:-","gi|564328503|ref|XP_006229314.1|",2716,0,"PREDICTED: tyrosine-protein phosphatase non-receptor type 5 isoform X1 [Rattus norvegicus]","gi|672036375|ref|XM_006229252.2|",3324,0,"PREDICTED: Rattus norvegicus protein tyrosine phosphatase, non-receptor type 5 (Ptpn5), transcript variant X1, mRNA","P54830",951,0,"Tyrosine-protein phosphatase non-receptor type 5","SPAC19D5.01",127,{"v":2e-29,"d":"2.00E-29"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0001934|positive regulation of protein phosphorylation;GO:0001975|response to amphetamine;GO:0002092|positive regulation of receptor internalization;GO:0006470|protein dephosphorylation;GO:0007568|aging;GO:0009410|response to xenobiotic stimulus;GO:0010976|positive regulation of neuron projection development;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0035640|exploration behavior;GO:0035902|response to immobilization stress;GO:0042307|positive regulation of protein import into nucleus;GO:0043407|negative regulation of MAP kinase activity;GO:1900273|positive regulation of long-term synaptic potentiation;GO:1901216|positive regulation of neuron death;GO:1903492|response to acetylsalicylate;GO:1903955|positive regulation of protein targeting to mitochondrion;GO:2001025|positive regulation of response to drug;","GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;GO:0008021|synaptic vesicle;GO:0016020|membrane;GO:0030424|axon;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0097060|synaptic membrane;GO:1990635|proximal dendrite;","GO:0001784|phosphotyrosine residue binding;GO:0004725|protein tyrosine phosphatase activity;GO:0019901|protein kinase binding;GO:0035254|glutamate receptor binding;GO:0042802|identical protein binding;GO:0051019|mitogen-activated protein kinase binding;","K18018","PTPN5; tyrosine-protein phosphatase non-receptor type 5 [EC:3.1.3.48]"]
["ENSRNOG00000068391",66,5.552927731,35,2.251565336,2.466252096,1.302320277,{"v":8.79e-06,"d":"8.79E-06"},{"v":9.27e-06,"d":"9.27E-06"},"up","yes","ENSRNOG00000068391","lncRNA","chr5:138131975-138133310:+","gi|51457|emb|CAA34748.1|",1241,{"v":3e-167,"d":"3.00E-167"},"heat shock-like protein [Mus musculus]","gi|48734826|gb|BC072489.1|",1333,0,"Rattus norvegicus heat shock protein 90, alpha (cytosolic), class A member 1, mRNA (cDNA clone MGC:91423 IMAGE:7105514), complete cds","P82995",484,{"v":1e-162,"d":"1.00E-162"},"Heat shock protein HSP 90-alpha","SPAC926.04c",241,{"v":7e-71,"d":"7.00E-71"},"COG0326","pfam00183","HSP90","Hsp90 protein.",".",".",".",".","."]
["ENSRNOG00000004404",19,1.598570104,2,0.128660876,12.42467912,3.635136688,{"v":8.85E-6,"d":"8.85E-06"},{"v":9.34e-06,"d":"9.34E-06"},"up","yes","Tac4","protein_coding","chr10:80207610-80216156:+","gi|27229228|ref|NP_758831.1|",833,{"v":2E-107,"d":"2.00E-107"},"tachykinin-4 preproprotein [Rattus norvegicus]","gi|54262187|ref|NM_172328.2|",1083,0,"Rattus norvegicus tachykinin 4 (hemokinin) (Tac4), mRNA","Q8CH01",325,{"v":8e-109,"d":"8.00E-109"},"Tachykinin-4",".",".",".",".","pfam05463","Sclerostin","Sclerostin (SOST). This family contains several mammalian sclerostin (SOST) proteins. SOST is thought to suppress bone formation. Mutations of the SOST gene lead to sclerosteosis, a progressive sclerosing bone dysplasia with an autosomal recessive mode of inheritance. Radiologically, it is characterized by a generalised hyperostosis and sclerosis leading to a markedly thickened and sclerotic skull, with mandible, ribs, clavicles and all long bones also being affected. Due to narrowing of the foramina of the cranial nerves, facial nerve palsy, hearing loss and atrophy of the optic nerves can occur. Sclerosteosis is clinically and radiologically very similar to van Buchem disease, mainly differentiated by hand malformations and a large stature in sclerosteosis patients.","GO:0003085|negative regulation of systemic arterial blood pressure;GO:0006954|inflammatory response;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007217|tachykinin receptor signaling pathway;GO:0008217|regulation of blood pressure;GO:0043303|mast cell degranulation;GO:0046878|positive regulation of saliva secretion;GO:0050965|detection of temperature stimulus involved in sensory perception of pain;GO:0051930|regulation of sensory perception of pain;GO:1902093|positive regulation of flagellated sperm motility;GO:1904057|negative regulation of sensory perception of pain;GO:1904058|positive regulation of sensory perception of pain;","GO:0005615|extracellular space;","GO:0005102|signaling receptor binding;GO:0031835|substance P receptor binding;GO:0031837|substance K receptor binding;GO:0048018|receptor ligand activity;","K05241","TAC4; tachykinin 4"]
["ENSRNOG00000051906",23,1.935111179,4,0.257321753,7.52020052,2.910771131,{"v":9.07e-06,"d":"9.07E-06"},{"v":9.55E-6,"d":"9.55E-06"},"up","yes","AABR07035561.2","protein_coding","chr12:17364080-17365280:+","gi|149028544|gb|EDL83916.1|",924,{"v":9e-124,"d":"9.00E-124"},"rCG55971, partial [Rattus norvegicus]","gi|672026601|ref|XM_006221297.2|",628,0,"PREDICTED: Rattus norvegicus similar to paired immunoglobin-like type 2 receptor beta (LOC680923), transcript variant X3, mRNA","Q6DKI7",171,{"v":1e-49,"d":"1.00E-49"},"Transmembrane protein PVRIG",".",".",".",".","pfam00387","PI-PLC-Y","Phosphatidylinositol-specific phospholipase C, Y domain. This associates with pfam00388 to form a single structural unit.",".",".",".",".","."]
["ENSRNOG00000069549",21,1.766840642,3,0.192991315,9.155026721,3.194564097,{"v":9.38E-6,"d":"9.38E-06"},{"v":9.86e-06,"d":"9.86E-06"},"up","yes","ENSRNOG00000069549","protein_coding","chr5:23768429-23768806:+","gi|678336953|emb|CDW75723.1|",372,{"v":2e-38,"d":"2.00E-38"},"UNKNOWN [Stylonychia lemnae]","gi|374429576|ref|NR_046246.1|",353,0,"Rattus norvegicus 28S ribosomal RNA (Rn28s), ribosomal RNA",".",".",".",".",".",".",".",".","pfam12979","DUF3863","Domain of Unknown Function with PDB structure (DUF3863). Domain based on 1-364 domain of PDB:3LM3 which is encoded by the BDI_3119 gene from Parabacteroides distasonis atcc 8503.",".",".",".",".","."]
["ENSRNOG00000049277",82,6.899092029,49,3.152191471,2.18866528,1.130051335,{"v":9.44e-06,"d":"9.44E-06"},{"v":9.93e-06,"d":"9.93E-06"},"up","yes","Syne4","protein_coding","chr1:85569545-85573760:+","gi|392344104|ref|XP_003748870.1|",1560,0,"PREDICTED: nesprin-4 isoform X2 [Rattus norvegicus]","gi|564327446|ref|XM_003748822.2|",1287,0,"PREDICTED: Rattus norvegicus nesprin-4-like (LOC100911963), transcript variant X2, mRNA","Q8CII8",524,0,"Nesprin-4",".",".",".",".","pfam10541","KASH","Nuclear envelope localisation domain. The KASH (for Klarsicht/ANC-1/Syne-1 homology) or KLS domain is a highly hydrophobic nuclear envelope localisation domain of approximately 60 amino acids comprising a 20-amino-acid transmembrane region and a 30-35-residue C-terminal region that lies between the inner and the outer nuclear membranes. During meiotic prophase, telomeres cluster to form a bouquet arrangement of chromosomes. SUN and KASH domain proteins form complexes that span both membranes of the nuclear envelope. The KASH domain links the dynein motor complex of the microtubules, through the outer nuclear membrane to the Sad1 domain in the inner nuclear membrane which then interacts with the bouquet proteins Bqt1 and Bqt2 that are complexed with Bqt4, Rap1 and Taz1 and attached to the telomere. SUN domain-containing proteins are essential for recruiting KASH domain proteins at the outer nuclear membrane, and KASH domains provide a generic NE tethering device for functionally distinct proteins whose cytoplasmic domains mediate nuclear positioning, maintain physical connections with other cellular organelles, and possibly even influence chromosome dynamics.","GO:0045198|establishment of epithelial cell apical/basal polarity;","GO:0016021|integral component of membrane;GO:0031309|integral component of nuclear outer membrane;GO:0034993|meiotic nuclear membrane microtubule tethering complex;",".","K23401","SYNE4; nesprin-4"]
["ENSRNOG00000054964",74,6.22600988,42,2.701878404,2.304326453,1.204345118,{"v":9.55E-6,"d":"9.55E-06"},{"v":1e-05,"d":"1.00E-05"},"up","yes","Aoah","protein_coding","chr17:43809638-44049148:-","gi|300794357|ref|NP_001178869.1|",3043,0,"acyloxyacyl hydrolase precursor [Rattus norvegicus]","gi|300794356|ref|NM_001191940.1|",1747,0,"Rattus norvegicus acyloxyacyl hydrolase (neutrophil) (Aoah), mRNA","O35298",1080,0,"Acyloxyacyl hydrolase",".",".",".",".","pfam00657","Lipase_GDSL","GDSL-like Lipase/Acylhydrolase.","GO:0006631|fatty acid metabolic process;GO:0008653|lipopolysaccharide metabolic process;GO:0009104|lipopolysaccharide catabolic process;GO:0050728|negative regulation of inflammatory response;","GO:0005576|extracellular region;GO:0043231|intracellular membrane-bounded organelle;","GO:0005509|calcium ion binding;GO:0050528|acyloxyacyl hydrolase activity;","K01065","AOAH; acyloxyacyl hydrolase [EC:3.1.1.77]"]
["ENSRNOG00000026518",33,2.776463865,10,0.643304382,4.315941168,2.109675199,{"v":9.56e-06,"d":"9.56E-06"},{"v":1e-05,"d":"1.00E-05"},"up","yes","Tmem156","protein_coding","chr14:43223381-43252449:+","gi|68341947|ref|NP_001020309.1|",1531,0,"transmembrane protein 156 [Rattus norvegicus]","gi|68341946|ref|NM_001025138.1|",1504,0,"Rattus norvegicus transmembrane protein 156 (Tmem156), mRNA","Q5BK38",594,0,"Transmembrane protein 156",".",".",".",".","pfam15106","TMEM156","TMEM156 protein family. The function of this family of transmembrane proteins, TMEM 156, has not, as yet, been determined. Members of this family are as yet uncharacterized. This family of proteins are found in eukaryotes. Proteins in this family are approximately 310 amino acids in length. In humans, the gene encoding this protein is located in the chromosomal position, 4p14.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000020872",36,3.028869671,12,0.771965258,3.92358288,1.972171675,{"v":9.57e-06,"d":"9.57E-06"},{"v":1.01E-5,"d":"1.01E-05"},"up","yes","Cd5","protein_coding","chr1:207365337-207386313:-","gi|149062413|gb|EDM12836.1|",2216,0,"CD5 antigen, isoform CRA_b [Rattus norvegicus]","gi|9506470|ref|NM_019295.1|",2016,0,"Rattus norvegicus Cd5 molecule (Cd5), mRNA","P51882",857,0,"T-cell surface glycoprotein CD5",".",".",".",".","pfam00530","SRCR","Scavenger receptor cysteine-rich domain. These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.","GO:0006897|endocytosis;GO:0009966|regulation of signal transduction;GO:0031295|T cell costimulation;GO:0097190|apoptotic signaling pathway;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0044214|spanning component of plasma membrane;","GO:0005044|scavenger receptor activity;GO:0005515|protein binding;","K06455","CD5; T-cell surface glycoprotein CD5"]
["ENSRNOG00000068224",83,6.983227298,50,3.216521909,2.171049194,1.118392416,{"v":9.9e-06,"d":"9.90E-06"},{"v":1.04E-5,"d":"1.04E-05"},"up","yes","ENSRNOG00000068224","lncRNA","chr3:44333774-44337077:+","gi|148667617|gb|EDL00034.1|",144,{"v":8e-08,"d":"8.00E-08"},"mCG141415 [Mus musculus]","gi|30425565|gb|AC109037.6|",132,{"v":4e-60,"d":"4.00E-60"},"Rattus norvegicus 18 BAC CH230-178G23 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["ENSRNOG00000020585",84,7.067362566,51,3.280852347,2.154123934,1.107101256,{"v":1.04E-5,"d":"1.04E-05"},{"v":1.08E-5,"d":"1.08E-05"},"up","yes","Tbxa2r","protein_coding","chr7:8383378-8388176:-","gi|564357987|ref|XP_006240908.1|",1475,0,"PREDICTED: thromboxane A2 receptor isoform X1 [Rattus norvegicus]","gi|8394421|ref|NM_017054.1|",1820,0,"Rattus norvegicus thromboxane A2 receptor (Tbxa2r), mRNA","P34978",572,0,"Thromboxane A2 receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0006954|inflammatory response;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007584|response to nutrient;GO:0009410|response to xenobiotic stimulus;GO:0019229|regulation of vasoconstriction;GO:0019932|second-messenger-mediated signaling;GO:0030104|water homeostasis;GO:0030194|positive regulation of blood coagulation;GO:0032496|response to lipopolysaccharide;GO:0033574|response to testosterone;GO:0038193|thromboxane A2 signaling pathway;GO:0045471|response to ethanol;GO:0045766|positive regulation of angiogenesis;GO:0045777|positive regulation of blood pressure;GO:0045907|positive regulation of vasoconstriction;GO:0045987|positive regulation of smooth muscle contraction;GO:0071222|cellular response to lipopolysaccharide;GO:0090051|negative regulation of cell migration involved in sprouting angiogenesis;","GO:0001669|acrosomal vesicle;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0016607|nuclear speck;","GO:0004960|thromboxane receptor activity;GO:0004961|thromboxane A2 receptor activity;GO:0005515|protein binding;","K04264","TBXA2R; thromboxane A2 receptor"]
["ENSRNOG00000065338",96,8.07698579,62,3.988487167,2.025075035,1.017975365,{"v":1.07e-05,"d":"1.07E-05"},{"v":1.12e-05,"d":"1.12E-05"},"up","yes","ENSRNOG00000065338","protein_coding","chr17:43062430-43065964:+","gi|397519157|ref|XP_003829735.1|",491,{"v":1e-64,"d":"1.00E-64"},"PREDICTED: zinc finger protein 3-like [Pan paniscus]","gi|672081985|ref|XR_596793.1|",3194,0,"PREDICTED: Rattus norvegicus zinc finger protein 192 (Zfp192), transcript variant X1, misc_RNA","P13682",149,{"v":1E-46,"d":"1.00E-46"},"Zinc finger protein 35",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.",".",".",".",".","."]
["ENSRNOG00000026387",28,2.355787522,7,0.450313067,5.23144384,2.387209175,{"v":1.09e-05,"d":"1.09E-05"},{"v":1.14e-05,"d":"1.14E-05"},"up","yes","Ms4a12","protein_coding","chr1:207882333-207893938:-","gi|564298855|ref|XP_006223705.1|",1590,0,"PREDICTED: membrane-spanning 4-domains subfamily A member 12 isoform X1 [Rattus norvegicus]","gi|672014671|ref|XM_006223643.2|",971,0,"PREDICTED: Rattus norvegicus membrane-spanning 4-domains, subfamily A, member 12 (Ms4a12), transcript variant X1, mRNA","Q9NXJ0",246,{"v":3e-77,"d":"3.00E-77"},"Membrane-spanning 4-domains subfamily A member 12",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.",".","GO:0016021|integral component of membrane;",".","K22190","MS4A3S; membrane-spanning 4-domains subfamily A member 3/4/8/12/15/18"]
["ENSRNOG00000018958",69,5.805333537,38,2.444556651,2.374800164,1.247806118,{"v":1.1E-5,"d":"1.10E-05"},{"v":1.15E-5,"d":"1.15E-05"},"up","yes","Mt3","protein_coding","chr19:10848755-10850158:-","gi|344243953|gb|EGW00057.1|",138,{"v":8e-09,"d":"8.00E-09"},"Metallothionein-3 [Cricetulus griseus]","gi|402765774|ref|NM_053968.3|",375,0,"Rattus norvegicus metallothionein 3 (Mt3), mRNA",".",".",".",".",".",".",".",".","pfam00131","Metallothio","Metallothionein.","GO:0001666|response to hypoxia;GO:0001934|positive regulation of protein phosphorylation;GO:0006112|energy reserve metabolic process;GO:0006707|cholesterol catabolic process;GO:0006829|zinc ion transport;GO:0006875|cellular metal ion homeostasis;GO:0006882|cellular zinc ion homeostasis;GO:0006915|apoptotic process;GO:0006979|response to oxidative stress;GO:0007420|brain development;GO:0010273|detoxification of copper ion;GO:0010507|negative regulation of autophagy;GO:0010628|positive regulation of gene expression;GO:0010940|positive regulation of necrotic cell death;GO:0010942|positive regulation of cell death;GO:0014002|astrocyte development;GO:0016570|histone modification;GO:0019430|removal of superoxide radicals;GO:0030308|negative regulation of cell growth;GO:0030517|negative regulation of axon extension;GO:0030949|positive regulation of vascular endothelial growth factor receptor signaling pathway;GO:0032095|regulation of response to food;GO:0032148|activation of protein kinase B activity;GO:0033210|leptin-mediated signaling pathway;GO:0034599|cellular response to oxidative stress;GO:0036091|positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress;GO:0043066|negative regulation of apoptotic process;GO:0043085|positive regulation of catalytic activity;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043491|protein kinase B signaling;GO:0043524|negative regulation of neuron apoptotic process;GO:0044242|cellular lipid catabolic process;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0050768|negative regulation of neurogenesis;GO:0050774|negative regulation of dendrite morphogenesis;GO:0050821|protein stabilization;GO:0051354|negative regulation of oxidoreductase activity;GO:0055069|zinc ion homeostasis;GO:0055073|cadmium ion homeostasis;GO:0060049|regulation of protein glycosylation;GO:0060547|negative regulation of necrotic cell death;GO:0070371|ERK1 and ERK2 cascade;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071276|cellular response to cadmium ion;GO:0071280|cellular response to copper ion;GO:0071294|cellular response to zinc ion;GO:0071456|cellular response to hypoxia;GO:0071732|cellular response to nitric oxide;GO:0097214|positive regulation of lysosomal membrane permeability;GO:1901215|negative regulation of neuron death;GO:2000117|negative regulation of cysteine-type endopeptidase activity;GO:2000296|negative regulation of hydrogen peroxide catabolic process;GO:2000376|positive regulation of oxygen metabolic process;GO:2000378|negative regulation of reactive oxygen species metabolic process;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005741|mitochondrial outer membrane;GO:0005791|rough endoplasmic reticulum;GO:0005840|ribosome;GO:0005874|microtubule;GO:0005886|plasma membrane;GO:0008021|synaptic vesicle;GO:0014069|postsynaptic density;GO:0016234|inclusion body;GO:0030424|axon;GO:0043197|dendritic spine;GO:0048471|perinuclear region of cytoplasm;GO:0097449|astrocyte projection;GO:0097450|astrocyte end-foot;","GO:0005507|copper ion binding;GO:0008270|zinc ion binding;GO:0030295|protein kinase activator activity;GO:0043027|cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0046870|cadmium ion binding;GO:0046872|metal ion binding;","K14740","MT3; metallothionein 3"]
["ENSRNOG00000007611",48,4.038492895,21,1.350939202,2.98939648,1.579854253,{"v":1.17E-5,"d":"1.17E-05"},{"v":1.22E-5,"d":"1.22E-05"},"up","yes","Hoxb7","protein_coding","chr10:81252553-81256034:+","gi|62945316|ref|NP_001017480.1|",1033,{"v":6e-137,"d":"6.00E-137"},"homeobox protein Hox-B7 [Rattus norvegicus]","gi|62945315|ref|NM_001017480.1|",1213,0,"Rattus norvegicus homeo box B7 (Hoxb7), mRNA","P18864",402,{"v":2e-138,"d":"2.00E-138"},"Homeobox protein Hox-B7",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0009952|anterior/posterior pattern specification;GO:0030099|myeloid cell differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048704|embryonic skeletal system morphogenesis;GO:0090190|positive regulation of branching involved in ureteric bud morphogenesis;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0016604|nuclear body;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09307","HOX_7; homeobox protein HoxA/B7"]
["ENSRNOG00000009656",88,7.403903641,55,3.5381741,2.092577536,1.06528108,{"v":1.22E-5,"d":"1.22E-05"},{"v":1.26E-5,"d":"1.26E-05"},"up","yes","Rspo1","protein_coding","chr5:137251659-137272933:+","gi|157818717|ref|NP_001101450.1|",1326,{"v":6e-178,"d":"6.00E-178"},"R-spondin-1 precursor [Rattus norvegicus]","gi|672053700|ref|XM_008764019.1|",1811,0,"PREDICTED: Rattus norvegicus R-spondin 1 (Rspo1), transcript variant X1, mRNA","Q9Z132",498,{"v":1E-172,"d":"1.00E-172"},"R-spondin-1",".",".",".",".","pfam00090","TSP_1","Thrombospondin type 1 domain.","GO:0001934|positive regulation of protein phosphorylation;GO:0002090|regulation of receptor internalization;GO:0007140|male meiotic nuclear division;GO:0008150|biological_process;GO:0010468|regulation of gene expression;GO:0030177|positive regulation of Wnt signaling pathway;GO:0060070|canonical Wnt signaling pathway;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:2000052|positive regulation of non-canonical Wnt signaling pathway;GO:2000254|regulation of male germ cell proliferation;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005634|nucleus;","GO:0001664|G protein-coupled receptor binding;GO:0003674|molecular_function;GO:0005102|signaling receptor binding;GO:0008201|heparin binding;","K19471","RSPO1; R-spondin 1"]
["ENSRNOG00000024390",58,4.879845581,29,1.865582707,2.61572192,1.387209175,{"v":1.22E-5,"d":"1.22E-05"},{"v":1.27E-5,"d":"1.27E-05"},"up","yes","Osm","protein_coding","chr14:79104344-79108313:+","gi|55741439|ref|NP_001006962.1|",1118,{"v":9e-147,"d":"9.00E-147"},"oncostatin-M precursor [Rattus norvegicus]","gi|672076593|ref|XM_006251200.2|",1490,0,"PREDICTED: Rattus norvegicus oncostatin M (Osm), transcript variant X2, mRNA","Q65Z15",435,{"v":3E-148,"d":"3.00E-148"},"Oncostatin-M",".",".",".",".","pfam01291","LIF_OSM","LIF / OSM family.","GO:0006955|immune response;GO:0007260|tyrosine phosphorylation of STAT protein;GO:0007422|peripheral nervous system development;GO:0008284|positive regulation of cell proliferation;GO:0009408|response to heat;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0032740|positive regulation of interleukin-17 production;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0038165|oncostatin-M-mediated signaling pathway;GO:0040008|regulation of growth;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0043410|positive regulation of MAPK cascade;GO:0045835|negative regulation of meiotic nuclear division;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046888|negative regulation of hormone secretion;GO:0048266|behavioral response to pain;GO:0050729|positive regulation of inflammatory response;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0051897|positive regulation of protein kinase B signaling;GO:2001235|positive regulation of apoptotic signaling pathway;","GO:0005615|extracellular space;","GO:0005125|cytokine activity;GO:0005147|oncostatin-M receptor binding;GO:0008083|growth factor activity;","K05418","OSM; oncostatin M"]
["ENSRNOG00000059456",31,2.608193328,9,0.578973944,4.504854418,2.171480484,{"v":1.25e-05,"d":"1.25E-05"},{"v":1.29E-5,"d":"1.29E-05"},"up","yes","Grk3","protein_coding","chr12:43624897-43731262:+","gi|6978467|ref|NP_037029.1|",3636,0,"beta-adrenergic receptor kinase 2 [Rattus norvegicus]","gi|145046260|ref|NM_012897.2|",2352,0,"Rattus norvegicus adrenergic, beta, receptor kinase 2 (Adrbk2), mRNA","P26819",1405,0,"Beta-adrenergic receptor kinase 2",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0001934|positive regulation of protein phosphorylation;GO:0002029|desensitization of G protein-coupled receptor signaling pathway;GO:0006468|protein phosphorylation;GO:0006886|intracellular protein transport;GO:0007165|signal transduction;GO:0007186|G protein-coupled receptor signaling pathway;GO:0009966|regulation of signal transduction;GO:0010259|multicellular organism aging;GO:0031623|receptor internalization;GO:0043278|response to morphine;GO:0043647|inositol phosphate metabolic process;GO:0045744|negative regulation of G protein-coupled receptor signaling pathway;GO:0046154|rhodopsin metabolic process;","GO:0005634|nucleus;GO:0005829|cytosol;GO:0005929|cilium;GO:0016020|membrane;GO:0030018|Z disc;GO:0030424|axon;GO:0043197|dendritic spine;GO:0043198|dendritic shaft;GO:0044292|dendrite terminus;GO:0045121|membrane raft;GO:0045202|synapse;GO:0048471|perinuclear region of cytoplasm;GO:0097225|sperm midpiece;","GO:0001664|G protein-coupled receptor binding;GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0004703|G protein-coupled receptor kinase activity;GO:0005524|ATP binding;GO:0031748|D1 dopamine receptor binding;GO:0047696|beta-adrenergic receptor kinase activity;","K00910","ADRBK, GRK; beta-adrenergic-receptor kinase [EC:2.7.11.15]"]
["ENSRNOG00000012175",26,2.187516985,6,0.385982629,5.667397494,2.502686392,{"v":1.33E-5,"d":"1.33E-05"},{"v":1.38E-5,"d":"1.38E-05"},"up","yes","Nfatc2","protein_coding","chr3:157198872-157328325:-","gi|157821773|ref|NP_001101275.1|",4154,0,"nuclear factor of activated T-cells, cytoplasmic 2 [Rattus norvegicus]","gi|157821772|ref|NM_001107805.1|",2824,0,"Rattus norvegicus nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (Nfatc2), mRNA","Q60591",1571,0,"Nuclear factor of activated T-cells, cytoplasmic 2",".",".",".",".","pfam00554","RHD","Rel homology domain (RHD). Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See pfam01833) that binds to DNA.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001816|cytokine production;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006974|cellular response to DNA damage stimulus;GO:0008150|biological_process;GO:0009410|response to xenobiotic stimulus;GO:0010628|positive regulation of gene expression;GO:0014904|myotube cell development;GO:0016477|cell migration;GO:0030890|positive regulation of B cell proliferation;GO:0033173|calcineurin-NFAT signaling cascade;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050853|B cell receptor signaling pathway;GO:1901741|positive regulation of myoblast fusion;GO:1905064|negative regulation of vascular smooth muscle cell differentiation;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:1990904|ribonucleoprotein complex;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003682|chromatin binding;GO:0003700|DNA-binding transcription factor activity;GO:0008134|transcription factor binding;GO:0019902|phosphatase binding;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K17332","NFATC2, NFAT1, NFATP; nuclear factor of activated T-cells, cytoplasmic 2"]
["ENSRNOG00000028250",26,2.187516985,6,0.385982629,5.667397494,2.502686392,{"v":1.33E-5,"d":"1.33E-05"},{"v":1.38E-5,"d":"1.38E-05"},"up","yes","Lax1","protein_coding","chr13:45134834-45145381:-","gi|62945342|ref|NP_001017491.1|",1979,0,"lymphocyte transmembrane adapter 1 [Rattus norvegicus]","gi|62945341|ref|NM_001017491.1|",2209,0,"Rattus norvegicus lymphocyte transmembrane adaptor 1 (Lax1), mRNA","Q5FVQ5",766,0,"Lymphocyte transmembrane adapter 1",".",".",".",".","pfam03326","Herpes_TAF50","Herpesvirus transcription activation factor (transactivator). This family includes EBV BRLF1 and similar ORF 50 proteins from other herpesviruses.","GO:0002250|adaptive immune response;GO:0006955|immune response;GO:0035556|intracellular signal transduction;GO:0042113|B cell activation;GO:0043407|negative regulation of MAP kinase activity;GO:0046649|lymphocyte activation;GO:0050851|antigen receptor-mediated signaling pathway;GO:0050868|negative regulation of T cell activation;","GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0019901|protein kinase binding;GO:0042169|SH2 domain binding;",".","."]
["ENSRNOG00000005082",49,4.122628164,22,1.41526964,2.912963047,1.5424874,{"v":1.35e-05,"d":"1.35E-05"},{"v":1.39e-05,"d":"1.39E-05"},"up","yes","Irf6","protein_coding","chr13:104672179-104691386:+","gi|1685128|gb|AAB36714.1|",2302,0,"interferon regulatory factor 6 [Mus musculus]","gi|157819782|ref|NM_001108859.1|",4044,0,"Rattus norvegicus interferon regulatory factor 6 (Irf6), mRNA","P97431",887,0,"Interferon regulatory factor 6",".",".",".",".","pfam10401","IRF-3","Interferon-regulatory factor 3. This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1).  Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.","GO:0002376|immune system process;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008150|biological_process;GO:0008285|negative regulation of cell proliferation;GO:0030216|keratinocyte differentiation;GO:0043588|skin development;GO:0043616|keratinocyte proliferation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048468|cell development;GO:0051726|regulation of cell cycle;GO:0060021|roof of mouth development;GO:0060173|limb development;GO:0060644|mammary gland epithelial cell differentiation;GO:1904888|cranial skeletal system development;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0030054|cell junction;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K10154","IRF6; interferon regulatory factor 6"]
["ENSRNOG00000019162",92,7.740444715,59,3.795495853,2.039376412,1.028128081,{"v":1.39e-05,"d":"1.39E-05"},{"v":1.43E-5,"d":"1.43E-05"},"up","yes","Emc9","protein_coding","chr15:29071883-29076098:-","gi|56605634|ref|NP_001008297.1|",1098,{"v":2E-149,"d":"2.00E-149"},"ER membrane protein complex subunit 9 [Rattus norvegicus]","gi|56605633|ref|NM_001008296.1|",816,0,"Rattus norvegicus ER membrane protein complex subunit 9 (Emc9), mRNA","Q5U1W7",427,{"v":7e-151,"d":"7.00E-151"},"ER membrane protein complex subunit 9",".",".",".",".","pfam03665","UPF0172","Uncharacterized protein family (UPF0172). In Chlamydomonas reinhardtii the protein TLA1 (truncated light-harvesting chlorophyll antenna size) apparently regulates genes that define the chlorophyll-a antenna size in the photosynthetic apparatus. This family was formerly known as UPF0172.","GO:0045050|protein insertion into ER membrane by stop-transfer membrane-anchor sequence;GO:0071816|tail-anchored membrane protein insertion into ER membrane;","GO:0005737|cytoplasm;GO:0072546|ER membrane protein complex;","GO:0032977|membrane insertase activity;","K23569","EMC8_9; ER membrane protein complex subunit 8/9"]
["ENSRNOG00000056825",92,7.740444715,59,3.795495853,2.039376412,1.028128081,{"v":1.39e-05,"d":"1.39E-05"},{"v":1.43E-5,"d":"1.43E-05"},"up","yes","AABR07072539.4","lncRNA","chr6:123970709-123978469:-","gi|564379463|ref|XP_006249439.1|",728,{"v":3e-125,"d":"3.00E-125"},"PREDICTED: 60S ribosomal protein L6 isoform X2 [Rattus norvegicus]","gi|672021090|ref|XR_601595.1|",568,0,"PREDICTED: Rattus norvegicus ribosomal protein L6, pseudogene 1 (Rpl6-ps1), misc_RNA","P21533",283,{"v":3e-126,"d":"3.00E-126"},"60S ribosomal protein L6","SPCC622.18",72,{"v":1E-22,"d":"1.00E-22"},"COG2163","pfam01159","Ribosomal_L6e","Ribosomal protein L6e.",".",".",".",".","."]
["ENSRNOG00000015668",67,5.637062999,37,2.380226213,2.368288766,1.243845,{"v":1.55e-05,"d":"1.55E-05"},{"v":1.59E-5,"d":"1.59E-05"},"up","yes","Ccl19","protein_coding","chr5:56963364-56965308:-","gi|755507561|ref|XP_006538477.2|",583,{"v":1e-72,"d":"1.00E-72"},"PREDICTED: C-C motif chemokine 19-like, partial [Mus musculus]","gi|157821836|ref|NM_001108661.1|",715,0,"Rattus norvegicus chemokine (C-C motif) ligand 19 (Ccl19), mRNA","O70460",177,{"v":9e-55,"d":"9.00E-55"},"C-C motif chemokine 19",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0001768|establishment of T cell polarity;GO:0001771|immunological synapse formation;GO:0002407|dendritic cell chemotaxis;GO:0002408|myeloid dendritic cell chemotaxis;GO:0002548|monocyte chemotaxis;GO:0002606|positive regulation of dendritic cell antigen processing and presentation;GO:0006954|inflammatory response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0010560|positive regulation of glycoprotein biosynthetic process;GO:0030593|neutrophil chemotaxis;GO:0031295|T cell costimulation;GO:0031640|killing of cells of other organism;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032735|positive regulation of interleukin-12 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0034695|response to prostaglandin E;GO:0042102|positive regulation of T cell proliferation;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043507|positive regulation of JUN kinase activity;GO:0043547|positive regulation of GTPase activity;GO:0043552|positive regulation of phosphatidylinositol 3-kinase activity;GO:0045627|positive regulation of T-helper 1 cell differentiation;GO:0045807|positive regulation of endocytosis;GO:0045860|positive regulation of protein kinase activity;GO:0046330|positive regulation of JNK cascade;GO:0048247|lymphocyte chemotaxis;GO:0048260|positive regulation of receptor-mediated endocytosis;GO:0048469|cell maturation;GO:0050921|positive regulation of chemotaxis;GO:0051209|release of sequestered calcium ion into cytosol;GO:0051897|positive regulation of protein kinase B signaling;GO:0060491|regulation of cell projection assembly;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098|chemokine-mediated signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071731|response to nitric oxide;GO:0090023|positive regulation of neutrophil chemotaxis;GO:0097029|mature conventional dendritic cell differentiation;GO:0098586|cellular response to virus;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:2000147|positive regulation of cell motility;GO:2000549|positive regulation of dendritic cell dendrite assembly;GO:2000669|negative regulation of dendritic cell apoptotic process;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0009897|external side of plasma membrane;","GO:0003674|molecular_function;GO:0008009|chemokine activity;GO:0031732|CCR7 chemokine receptor binding;GO:0031735|CCR10 chemokine receptor binding;GO:0042379|chemokine receptor binding;GO:0048020|CCR chemokine receptor binding;","K05512","CCL19, ELC; C-C motif chemokine 19"]
["ENSRNOG00000010603",16,1.346164298,1,0.064330438,20.92577536,4.387209175,{"v":1.56E-5,"d":"1.56E-05"},{"v":1.59E-5,"d":"1.59E-05"},"up","yes","Gzma","protein_coding","chr2:44740569-44752493:-","gi|149059360|gb|EDM10367.1|",1376,0,"granzyme A [Rattus norvegicus]","gi|23618882|ref|NM_153468.1|",771,0,"Rattus norvegicus granzyme A (Gzma), mRNA","P11032",411,{"v":1e-143,"d":"1.00E-143"},"Granzyme A","VC1649",87.4,{"v":2e-18,"d":"2.00E-18"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0009617|response to bacterium;GO:0032078|negative regulation of endodeoxyribonuclease activity;GO:0043065|positive regulation of apoptotic process;GO:0043392|negative regulation of DNA binding;GO:0051354|negative regulation of oxidoreductase activity;GO:0051603|proteolysis involved in cellular protein catabolic process;GO:0070269|pyroptosis;GO:1902483|cytotoxic T cell apoptotic process;","GO:0005634|nucleus;","GO:0004252|serine-type endopeptidase activity;GO:0008236|serine-type peptidase activity;GO:0042803|protein homodimerization activity;","K01352","GZMA; granzyme A [EC:3.4.21.78]"]
["ENSRNOG00000048239",16,1.346164298,1,0.064330438,20.92577536,4.387209175,{"v":1.56E-5,"d":"1.56E-05"},{"v":1.59E-5,"d":"1.59E-05"},"up","yes","Cxcr1","protein_coding","chr9:75766770-75771084:-","gi|9506809|ref|NP_062183.1|",1596,0,"C-X-C chemokine receptor type 1 [Rattus norvegicus]","gi|77377274|gb|AC113473.20|",1302,0,"Mus musculus chromosome 1, clone RP23-280F6, complete sequence","P70612",619,0,"C-X-C chemokine receptor type 1",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0006955|immune response;GO:0007166|cell surface receptor signaling pathway;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0019722|calcium-mediated signaling;GO:0030593|neutrophil chemotaxis;GO:0031623|receptor internalization;GO:0038112|interleukin-8-mediated signaling pathway;GO:0060326|cell chemotaxis;GO:0070098|chemokine-mediated signaling pathway;","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0004918|interleukin-8 receptor activity;GO:0016493|C-C chemokine receptor activity;GO:0019957|C-C chemokine binding;GO:0019959|interleukin-8 binding;","K04175","CXCR1, IL8RA, CD181; C-X-C chemokine receptor type 1"]
["ENSRNOG00000004488",15,1.26202903,0,0.032165219,39.2358288,5.29409977,{"v":1.61e-05,"d":"1.61E-05"},{"v":1.64e-05,"d":"1.64E-05"},"up","yes","Bdkrb1","protein_coding","chr6:124510870-124513747:+","gi|13540665|ref|NP_110478.1|",1573,0,"B1 bradykinin receptor [Rattus norvegicus]","gi|672056812|ref|XM_008764861.1|",1542,0,"PREDICTED: Rattus norvegicus bradykinin receptor B1 (Bdkrb1), transcript variant X1, mRNA","P97583",610,0,"B1 bradykinin receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001933|negative regulation of protein phosphorylation;GO:0002687|positive regulation of leukocyte migration;GO:0006954|inflammatory response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007205|protein kinase C-activating G protein-coupled receptor signaling pathway;GO:0009612|response to mechanical stimulus;GO:0016477|cell migration;GO:0019233|sensory perception of pain;GO:0019371|cyclooxygenase pathway;GO:0030308|negative regulation of cell growth;GO:0032496|response to lipopolysaccharide;GO:0045776|negative regulation of blood pressure;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;GO:0060085|smooth muscle relaxation of the bladder outlet;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0043005|neuron projection;","GO:0004930|G protein-coupled receptor activity;GO:0004947|bradykinin receptor activity;GO:0042277|peptide binding;","K03915","BDKRB1; bradykinin receptor B1"]
["ENSRNOG00000009797",22,1.85097591,4,0.257321753,7.19323528,2.846640793,{"v":1.77E-5,"d":"1.77E-05"},{"v":1.79e-05,"d":"1.79E-05"},"up","yes","Aqp3","protein_coding","chr5:56239201-56244720:-","gi|117558826|gb|AAI27491.1|",1526,0,"Aquaporin 3 [Rattus norvegicus]","gi|117558825|gb|BC127490.1|",1792,0,"Rattus norvegicus aquaporin 3, mRNA (cDNA clone MGC:156623 IMAGE:8366493), complete cds","P47862",589,0,"Aquaporin-3","DR1929",185,{"v":1E-52,"d":"1.00E-52"},"COG0580","pfam00230","MIP","Major intrinsic protein. MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.","GO:0002684|positive regulation of immune system process;GO:0006833|water transport;GO:0015793|glycerol transport;GO:0015840|urea transport;GO:0032526|response to retinoic acid;GO:0042476|odontogenesis;GO:0055085|transmembrane transport;GO:0070295|renal water absorption;GO:0071456|cellular response to hypoxia;GO:0071918|urea transmembrane transport;GO:0090650|cellular response to oxygen-glucose deprivation;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0046930|pore complex;","GO:0015204|urea transmembrane transporter activity;GO:0015250|water channel activity;GO:0015254|glycerol channel activity;GO:0015288|porin activity;GO:0042802|identical protein binding;","K09876","AQP3; aquaporin-3"]
["ENSRNOG00000042360",18,1.514434836,2,0.128660876,11.77074864,3.557134176,{"v":1.79e-05,"d":"1.79E-05"},{"v":1.81e-05,"d":"1.81E-05"},"up","yes","Treml4","protein_coding","chr9:12721815-12743253:-","gi|564311158|ref|XP_006226779.1|",1081,{"v":3e-145,"d":"3.00E-145"},"PREDICTED: trem-like transcript 4 protein isoform X3 [Rattus norvegicus]","gi|255003765|ref|NM_001033922.2|",447,0,"Mus musculus triggering receptor expressed on myeloid cells-like 4 (Treml4), transcript variant 1, mRNA","Q3LRV9",338,{"v":4e-114,"d":"4.00E-114"},"Trem-like transcript 4 protein",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0002230|positive regulation of defense response to virus by host;GO:0002457|T cell antigen processing and presentation;GO:0006911|phagocytosis, engulfment;GO:0008104|protein localization;GO:0034157|positive regulation of toll-like receptor 7 signaling pathway;GO:0034165|positive regulation of toll-like receptor 9 signaling pathway;GO:0034181|positive regulation of toll-like receptor 13 signaling pathway;","GO:0005765|lysosomal membrane;GO:0005783|endoplasmic reticulum;GO:0010008|endosome membrane;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000042524",18,1.514434836,2,0.128660876,11.77074864,3.557134176,{"v":1.79e-05,"d":"1.79E-05"},{"v":1.81e-05,"d":"1.81E-05"},"up","yes","Milr1","protein_coding","chr10:91687831-91705282:+","gi|149054592|gb|EDM06409.1|",1197,{"v":5e-159,"d":"5.00E-159"},"mast cell antigen 32, isoform CRA_a [Rattus norvegicus]","gi|11024661|ref|NM_021585.1|",1650,0,"Rattus norvegicus mast cell immunoglobulin-like receptor 1 (Milr1), mRNA","Q62875",418,{"v":2e-142,"d":"2.00E-142"},"Allergin-1",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0007166|cell surface receptor signaling pathway;GO:0033004|negative regulation of mast cell activation;GO:0043303|mast cell degranulation;GO:0098742|cell-cell adhesion via plasma-membrane adhesion molecules;","GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;","GO:0004888|transmembrane signaling receptor activity;",".","."]
["ENSRNOG00000050034",18,1.514434836,2,0.128660876,11.77074864,3.557134176,{"v":1.79e-05,"d":"1.79E-05"},{"v":1.81e-05,"d":"1.81E-05"},"up","yes","ENSRNOG00000050034","protein_coding","chr19:22386757-22439405:-","gi|672033178|ref|XP_008756363.1|",888,{"v":4e-118,"d":"4.00E-118"},"PREDICTED: disks large homolog 5-like isoform X1 [Rattus norvegicus]","gi|672033177|ref|XM_008758141.1|",595,0,"PREDICTED: Rattus norvegicus hypothetical protein LOC679730 (LOC679730), transcript variant X1, mRNA","E9Q9R9",69.7,{"v":3e-12,"d":"3.00E-12"},"Disks large homolog 5",".",".",".",".","pfam04822","Takusan","Takusan. This domain is named takusan, which is a Japanese word meaning 'many'. Members of this family regulate synaptic activity.",".",".",".",".","."]
["ENSRNOG00000002026",78,6.562550954,47,3.023530595,2.170492657,1.118022542,{"v":1.84E-5,"d":"1.84E-05"},{"v":1.86e-05,"d":"1.86E-05"},"up","yes","Dnajc28","protein_coding","chr11:30853526-30858441:-","gi|62078983|ref|NP_001014146.1|",2015,0,"dnaJ homolog subfamily C member 28 [Rattus norvegicus]","gi|49615110|gb|AC120974.7|",3233,0,"Rattus norvegicus 11 BAC CH230-358O2 (Children's Hospital Oakland Research Institute) complete sequence","Q8VCE1",678,0,"DnaJ homolog subfamily C member 28","all4355",53.5,{"v":5e-07,"d":"5.00E-07"},"COG2214","pfam09350","DUF1992","Domain of unknown function (DUF1992). This family of proteins are functionally uncharacterized.","GO:0006890|retrograde vesicle-mediated transport, Golgi to ER;GO:0007030|Golgi organization;GO:0048213|Golgi vesicle prefusion complex stabilization;","GO:0017119|Golgi transport complex;",".","K19373","DNAJC28; DnaJ homolog subfamily C member 28"]
["ENSRNOG00000007896",20,1.682705373,3,0.192991315,8.719073067,3.124174769,{"v":1.86e-05,"d":"1.86E-05"},{"v":1.88E-5,"d":"1.88E-05"},"up","yes","Klhl38","protein_coding","chr7:89855148-89864276:-","gi|148697356|gb|EDL29303.1|",3176,0,"RIKEN cDNA 8230402K04, partial [Mus musculus]","gi|68163454|ref|NM_001025008.1|",2641,0,"Rattus norvegicus kelch-like family member 38 (Klhl38), mRNA","Q5BK60",1216,0,"Kelch-like protein 38",".",".",".",".","pfam07707","BACK","BTB And C-terminal Kelch. This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).",".",".",".","K13959","KLHL38; kelch-like protein 38"]
["ENSRNOG00000022859",39,3.281275477,15,0.964956573,3.400438496,1.765720798,{"v":1.91E-5,"d":"1.91E-05"},{"v":1.93e-05,"d":"1.93E-05"},"up","yes","Trem1","protein_coding","chr9:12763819-12779203:-","gi|564367096|ref|XP_006244488.1|",997,{"v":8e-133,"d":"8.00E-133"},"PREDICTED: triggering receptor expressed on myeloid cells 1 isoform X1 [Rattus norvegicus]","gi|672064258|ref|XM_006244426.2|",992,0,"PREDICTED: Rattus norvegicus triggering receptor expressed on myeloid cells 1 (Trem1), transcript variant X1, mRNA","Q9JKE2",304,{"v":3e-101,"d":"3.00E-101"},"Triggering receptor expressed on myeloid cells 1",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0001954|positive regulation of cell-matrix adhesion;GO:0002367|cytokine production involved in immune response;GO:0002526|acute inflammatory response;GO:0010666|positive regulation of cardiac muscle cell apoptotic process;GO:0010759|positive regulation of macrophage chemotaxis;GO:0016477|cell migration;GO:0030593|neutrophil chemotaxis;GO:0032602|chemokine production;GO:0045087|innate immune response;GO:0070945|neutrophil mediated killing of gram-negative bacterium;GO:0071222|cellular response to lipopolysaccharide;GO:0071305|cellular response to vitamin D;GO:0072672|neutrophil extravasation;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0038023|signaling receptor activity;GO:0097110|scaffold protein binding;","K14362","TREM1, CD354; triggering receptor expressed on myeloid cells 1"]
["ENSRNOG00000018311",53,4.459169238,26,1.672591393,2.666024265,1.414689911,{"v":2.2e-05,"d":"2.20E-05"},{"v":2.2e-05,"d":"2.20E-05"},"up","yes","Cd19","protein_coding","chr1:180987286-180993975:-","gi|201021269|ref|NP_001013255.2|",2211,0,"B-lymphocyte antigen CD19 precursor [Rattus norvegicus]","gi|686661098|ref|NM_001013237.3|",2281,0,"Rattus norvegicus CD19 molecule (Cd19), mRNA","P25918",760,0,"B-lymphocyte antigen CD19",".",".",".",".","pfam05255","UPF0220","Uncharacterized protein family (UPF0220). This family of proteins is functionally uncharacterized.","GO:0001923|B-1 B cell differentiation;GO:0002322|B cell proliferation involved in immune response;GO:0016064|immunoglobulin mediated immune response;GO:0019724|B cell mediated immunity;GO:0043552|positive regulation of phosphatidylinositol 3-kinase activity;GO:0050851|antigen receptor-mediated signaling pathway;GO:0050853|B cell receptor signaling pathway;GO:0050855|regulation of B cell receptor signaling pathway;GO:0050864|regulation of B cell activation;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;","GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0032991|protein-containing complex;",".","K06465","CD19; B-lymphocyte antigen CD19"]
["ENSRNOG00000022428",33,2.776463865,11,0.70763482,3.92358288,1.972171675,{"v":2.25e-05,"d":"2.25E-05"},{"v":2.25e-05,"d":"2.25E-05"},"up","yes","Flrt1","protein_coding","chr1:204275367-204353750:-","gi|41351537|ref|NP_958813.1|",3061,0,"leucine-rich repeat transmembrane protein FLRT1 precursor [Mus musculus]","gi|672039469|ref|XM_008760167.1|",10641,0,"PREDICTED: Rattus norvegicus fibronectin leucine rich transmembrane protein 1 (Flrt1), transcript variant X1, mRNA","Q6RKD8",1183,0,"Leucine-rich repeat transmembrane protein FLRT1","SPy1798",75.1,{"v":5e-12,"d":"5.00E-12"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0008543|fibroblast growth factor receptor signaling pathway;GO:0016358|dendrite development;GO:0051965|positive regulation of synapse assembly;GO:1990138|neuron projection extension;","GO:0005615|extracellular space;GO:0005887|integral component of plasma membrane;GO:0005911|cell-cell junction;GO:0005925|focal adhesion;GO:0031410|cytoplasmic vesicle;GO:0032809|neuronal cell body membrane;GO:0044306|neuron projection terminus;GO:0048471|perinuclear region of cytoplasm;","GO:0005104|fibroblast growth factor receptor binding;","K16362","FLRT; leucine-rich repeat transmembrane protein FLRT"]
["ENSRNOG00000028649",33,2.776463865,11,0.70763482,3.92358288,1.972171675,{"v":2.25e-05,"d":"2.25E-05"},{"v":2.25e-05,"d":"2.25E-05"},"up","yes","Tox3","protein_coding","chr19:16648342-16757148:+","gi|334351203|sp|B7SBD2.1|TOX3_RAT",1510,0,"RecName: Full=TOX high mobility group box family member 3; AltName: Full=Trinucleotide repeat-containing gene 9 protein","gi|672084093|ref|XM_006255187.2|",3047,0,"PREDICTED: Rattus norvegicus TOX high mobility group box family member 3 (Tox3), transcript variant X1, mRNA","B7SBD2",586,0,"TOX high mobility group box family member 3",".",".",".",".","pfam00505","HMG_box","HMG (high mobility group) box.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0006915|apoptotic process;GO:0019722|calcium-mediated signaling;GO:0042981|regulation of apoptotic process;GO:0043524|negative regulation of neuron apoptotic process;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003713|transcription coactivator activity;GO:0005515|protein binding;GO:0031490|chromatin DNA binding;GO:0042803|protein homodimerization activity;GO:0051219|phosphoprotein binding;",".","."]
["ENSRNOG00000067556",33,2.776463865,11,0.70763482,3.92358288,1.972171675,{"v":2.25e-05,"d":"2.25E-05"},{"v":2.25e-05,"d":"2.25E-05"},"up","yes","ENSRNOG00000067556","lncRNA","chr1:243438450-243442581:+","gi|696994985|ref|XP_009564302.1|",141,{"v":3E-11,"d":"3.00E-11"},"PREDICTED: LOW QUALITY PROTEIN: RNA-directed DNA polymerase from mobile element jockey-like, partial [Cuculus canorus]","gi|30270591|gb|AC103018.7|",554,0,"Rattus norvegicus 1 CH230-196F22 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam09492","Pec_lyase","Pectic acid lyase. Members of this family are isozymes of pectate lyase (EC:4.2.2.2), also called polygalacturonic transeliminase and alpha-1,4-D-endopolygalacturonic acid lyase.",".",".",".",".","."]
["ENSRNOG00000054764",66,5.552927731,37,2.380226213,2.332941172,1.222149928,{"v":2.34E-5,"d":"2.34E-05"},{"v":2.33e-05,"d":"2.33E-05"},"up","yes","Flt3","protein_coding","chr12:7623930-7699474:+","gi|281371429|ref|NP_001094292.1|",5373,0,"receptor-type tyrosine-protein kinase FLT3 precursor [Rattus norvegicus]","gi|689971733|ref|NM_001100822.2|",3655,0,"Rattus norvegicus fms-related tyrosine kinase 3 (Flt3), mRNA","Q00342",1880,0,"Receptor-type tyrosine-protein kinase FLT3",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001776|leukocyte homeostasis;GO:0001934|positive regulation of protein phosphorylation;GO:0002318|myeloid progenitor cell differentiation;GO:0002320|lymphoid progenitor cell differentiation;GO:0002328|pro-B cell differentiation;GO:0002572|pro-T cell differentiation;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007275|multicellular organism development;GO:0008285|negative regulation of cell proliferation;GO:0009791|post-embryonic development;GO:0010243|response to organonitrogen compound;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0019221|cytokine-mediated signaling pathway;GO:0019882|antigen processing and presentation;GO:0030097|hemopoiesis;GO:0030098|lymphocyte differentiation;GO:0030183|B cell differentiation;GO:0031100|animal organ regeneration;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032727|positive regulation of interferon-alpha production;GO:0032729|positive regulation of interferon-gamma production;GO:0032735|positive regulation of interleukin-12 production;GO:0033674|positive regulation of kinase activity;GO:0035726|common myeloid progenitor cell proliferation;GO:0036145|dendritic cell homeostasis;GO:0040018|positive regulation of multicellular organism growth;GO:0045578|negative regulation of B cell differentiation;GO:0046651|lymphocyte proliferation;GO:0046777|protein autophosphorylation;GO:0048535|lymph node development;GO:0048536|spleen development;GO:0048873|homeostasis of number of cells within a tissue;GO:0071345|cellular response to cytokine stimulus;GO:0071385|cellular response to glucocorticoid stimulus;GO:0097028|dendritic cell differentiation;GO:0098586|cellular response to virus;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0032991|protein-containing complex;GO:0043235|receptor complex;","GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004896|cytokine receptor activity;GO:0005524|ATP binding;GO:0019838|growth factor binding;GO:0031625|ubiquitin protein ligase binding;GO:0035259|glucocorticoid receptor binding;GO:0043548|phosphatidylinositol 3-kinase binding;GO:0043621|protein self-association;GO:0044877|protein-containing complex binding;","K05092","FLT3, FLK2, CD135; fms-related tyrosine kinase 3 [EC:2.7.10.1]"]
["ENSRNOG00000026653",84,7.067362566,53,3.409513224,2.072836239,1.051606143,{"v":2.35e-05,"d":"2.35E-05"},{"v":2.33e-05,"d":"2.33E-05"},"up","yes","Hcar2","protein_coding","chr12:32726184-32728504:+","gi|31324560|ref|NP_852141.1|",1741,0,"hydroxycarboxylic acid receptor 2 [Rattus norvegicus]","gi|31324559|ref|NM_181476.1|",1083,0,"Rattus norvegicus niacin receptor 1 (Niacr1), mRNA","Q80Z39",675,0,"Hydroxycarboxylic acid receptor 2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001781|neutrophil apoptotic process;GO:0007186|G protein-coupled receptor signaling pathway;GO:0033031|positive regulation of neutrophil apoptotic process;GO:0035590|purinergic nucleotide receptor signaling pathway;GO:0050995|negative regulation of lipid catabolic process;GO:0070165|positive regulation of adiponectin secretion;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030054|cell junction;","GO:0001614|purinergic nucleotide receptor activity;GO:0004930|G protein-coupled receptor activity;GO:0005525|GTP binding;GO:0070553|nicotinic acid receptor activity;","K08402","HCAR2_3, GPR109; hydroxycarboxylic acid receptor 2/3"]
["ENSRNOG00000046667",85,7.151497835,54,3.473843662,2.05867003,1.041712609,{"v":2.43e-05,"d":"2.43E-05"},{"v":2.41E-5,"d":"2.41E-05"},"up","yes","Fosb","protein_coding","chr1:78954115-78961465:-","gi|667285956|ref|XP_008575975.1|",1049,{"v":5e-129,"d":"5.00E-129"},"PREDICTED: protein fosB isoform X2 [Galeopterus variegatus]","gi|672034902|ref|XM_008758883.1|",3633,0,"PREDICTED: Rattus norvegicus FBJ osteosarcoma oncogene B (Fosb), transcript variant X1, mRNA","P13346",230,{"v":2e-65,"d":"2.00E-65"},"Protein fosB",".",".",".",".","pfam03154","Atrophin-1","Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0006366|transcription by RNA polymerase II;GO:0007565|female pregnancy;GO:0009410|response to xenobiotic stimulus;GO:0009612|response to mechanical stimulus;GO:0032570|response to progesterone;GO:0032870|cellular response to hormone stimulus;GO:0043278|response to morphine;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0051412|response to corticosterone;GO:0051591|response to cAMP;GO:0071277|cellular response to calcium ion;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0043231|intracellular membrane-bounded organelle;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003690|double-stranded DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09029","FOSB; protein FosB"]
["ENSRNOG00000000638",75,6.310145148,45,2.894869718,2.179768267,1.124174769,{"v":2.46e-05,"d":"2.46E-05"},{"v":2.44E-5,"d":"2.44E-05"},"up","yes","Zfp365","protein_coding","chr20:20666240-20691238:+","gi|68341937|ref|NP_001020316.1|",2075,0,"protein ZNF365 [Rattus norvegicus]","gi|68341936|ref|NM_001025145.1|",2711,0,"Rattus norvegicus zinc finger protein 365 (Zfp365), mRNA","Q5PQS2",803,0,"Protein ZNF365",".",".",".",".","pfam13654","AAA_32","AAA domain. This family includes a wide variety of AAA domains including some that have lost essential nucleotide binding residues in the P-loop.","GO:0000281|mitotic cytokinesis;GO:0000723|telomere maintenance;GO:0010569|regulation of double-strand break repair via homologous recombination;GO:0010975|regulation of neuron projection development;GO:0010977|negative regulation of neuron projection development;GO:0021687|cerebellar molecular layer morphogenesis;GO:0033566|gamma-tubulin complex localization;GO:0048714|positive regulation of oligodendrocyte differentiation;GO:0060997|dendritic spine morphogenesis;GO:0110026|regulation of DNA strand resection involved in replication fork processing;GO:0140059|dendrite arborization;","GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0034451|centriolar satellite;GO:0043231|intracellular membrane-bounded organelle;","GO:0005515|protein binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0046872|metal ion binding;","K16737","ZNF365, Su48; protein ZNF365"]
["ENSRNOG00000005132",60,5.048116119,32,2.058574022,2.4522393,1.29409977,{"v":2.47e-05,"d":"2.47E-05"},{"v":2.45e-05,"d":"2.45E-05"},"up","yes","Slc52a3","protein_coding","chr3:140509473-140514096:+","gi|564343591|ref|XP_006235300.1|",2210,0,"PREDICTED: solute carrier family 52, riboflavin transporter, member 3 isoform X1 [Rattus norvegicus]","gi|672047468|ref|XM_006235238.2|",2221,0,"PREDICTED: Rattus norvegicus solute carrier family 52, riboflavin transporter, member 3 (Slc52a3), transcript variant X2, mRNA","Q4FZU9",853,0,"Solute carrier family 52, riboflavin transporter, member 3",".",".",".",".","pfam06237","DUF1011","Protein of unknown function (DUF1011). Family of uncharacterized eukaryotic proteins.","GO:0007605|sensory perception of sound;GO:0032218|riboflavin transport;GO:0034605|cellular response to heat;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;","GO:0032217|riboflavin transmembrane transporter activity;","K14620","SLC52A3, RFT2; riboflavin transporter 2"]
["ENSRNOG00000008526",49,4.122628164,23,1.479600078,2.78631248,1.478357063,{"v":2.47e-05,"d":"2.47E-05"},{"v":2.45e-05,"d":"2.45E-05"},"up","yes","Pdzd3","protein_coding","chr8:44584390-44588860:-","gi|300795477|ref|NP_001178925.1|",2407,0,"Na(+)/H(+) exchange regulatory cofactor NHE-RF4 [Rattus norvegicus]","gi|300795476|ref|NM_001191996.1|",2109,0,"Rattus norvegicus PDZ domain containing 3 (Pdzd3), mRNA","Q99MJ6",845,0,"Na(+)/H(+) exchange regulatory cofactor NHE-RF4",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.","GO:0006811|ion transport;GO:0007168|receptor guanylyl cyclase signaling pathway;GO:0010754|negative regulation of cGMP-mediated signaling;GO:0031283|negative regulation of guanylate cyclase activity;GO:0072659|protein localization to plasma membrane;","GO:0005737|cytoplasm;GO:0005903|brush border;GO:0016020|membrane;GO:0016324|apical plasma membrane;GO:0043296|apical junction complex;GO:0045177|apical part of cell;","GO:0008022|protein C-terminus binding;GO:0030251|guanylate cyclase inhibitor activity;GO:0043495|protein membrane anchor;GO:1990381|ubiquitin-specific protease binding;","K24059","PDZD3; PDZ domain-containing protein 3"]
["ENSRNOG00000064855",49,4.122628164,23,1.479600078,2.78631248,1.478357063,{"v":2.47e-05,"d":"2.47E-05"},{"v":2.45e-05,"d":"2.45E-05"},"up","yes","ENSRNOG00000064855","lncRNA","chr2:183842051-183844322:+","gi|149030597|gb|EDL85634.1|",176,{"v":2E-12,"d":"2.00E-12"},"rCG52010, isoform CRA_a [Rattus norvegicus]","gi|51262144|gb|BC079138.1|",250,{"v":3e-126,"d":"3.00E-126"},"Rattus norvegicus cDNA clone IMAGE:7127764",".",".",".",".",".",".",".",".","pfam09863","DUF2090","Uncharacterized protein conserved in bacteria (DUF2090). This domain, found in various prokaryotic carbohydrate kinases, has no known function.",".",".",".",".","."]
["ENSRNOG00000038478",67,5.637062999,38,2.444556651,2.305965377,1.205370852,{"v":2.49e-05,"d":"2.49E-05"},{"v":2.47e-05,"d":"2.47E-05"},"up","yes","AABR07029613.1","protein_coding","chr10:39768658-39769293:-","gi|752387259|ref|XP_011217426.1|",858,{"v":8e-114,"d":"8.00E-114"},"PREDICTED: high mobility group protein B1 [Ailuropoda melanoleuca]","gi|672040021|ref|XR_590620.1|",582,0,"PREDICTED: Rattus norvegicus high-mobility group box 1, pseudogene 4 (Hmgb1-ps4), misc_RNA","P63159",311,{"v":3e-106,"d":"3.00E-106"},"High mobility group protein B1","YBR089c-a",69.7,{"v":1E-14,"d":"1.00E-14"},"COG5648","pfam09011","HMG_box_2","HMG-box domain. This short 71 residue domain is an HMG-box domain. HMG-box domains mediate re-modelling of chromatin-structure. Mammalian HMG-box proteins are of two types: those that are non-sequence-specific DNA-binding proteins with two HMG-box domains and a long highly acidic C-tail; and a diverse group of sequence-specific transcription factor-proteins with either a single HMG-box or up to six copies, and no acidic C-tail.","GO:0002250|adaptive immune response;GO:0006281|DNA repair;GO:0006310|DNA recombination;GO:0006914|autophagy;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0008150|biological_process;GO:0045087|innate immune response;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005634|nucleus;GO:0005694|chromosome;GO:0005793|endoplasmic reticulum-Golgi intermediate compartment;GO:0005886|plasma membrane;","GO:0003674|molecular_function;","K10802","HMGB1; high mobility group protein B1"]
["ENSRNOG00000058775",25,2.103381716,6,0.385982629,5.449420667,2.446102864,{"v":2.5e-05,"d":"2.50E-05"},{"v":2.48E-5,"d":"2.48E-05"},"up","yes","Ly49s7","protein_coding","chr4:164761855-164779735:-","gi|57222316|ref|NP_001009494.1|",1336,0,"Ly49 stimulatory receptor 7 [Rattus norvegicus]","gi|57222315|ref|NM_001009494.1|",1054,0,"Rattus norvegicus Ly49 stimulatory receptor 7 (Ly49s7), mRNA","Q60652",300,{"v":1e-98,"d":"1.00E-98"},"Killer cell lectin-like receptor 5",".",".",".",".","pfam08391","Ly49","Ly49-like protein, N-terminal region. The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000011360",68,5.721198268,39,2.508887089,2.280372956,1.189269797,{"v":2.65E-5,"d":"2.65E-05"},{"v":2.61e-05,"d":"2.61E-05"},"up","yes","Dkk2","protein_coding","chr2:220568338-220660225:+","gi|157816965|ref|NP_001099942.1|",1368,{"v":1e-178,"d":"1.00E-178"},"dickkopf-related protein 2 precursor [Rattus norvegicus]","gi|157816964|ref|NM_001106472.1|",3087,0,"Rattus norvegicus dickkopf WNT signaling pathway inhibitor 2 (Dkk2), mRNA","Q9QYZ8",526,{"v":3e-178,"d":"3.00E-178"},"Dickkopf-related protein 2",".",".",".",".","pfam04706","Dickkopf_N","Dickkopf N-terminal cysteine-rich region. Dickkopf proteins are a class of Wnt antagonists. They possess two conserved cysteine-rich regions. This family represents the N-terminal one. The C-terminal region has been found to share significant sequence similarity to the colipase fold, pfam01114, pfam02740.","GO:0030178|negative regulation of Wnt signaling pathway;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:2000272|negative regulation of signaling receptor activity;","GO:0005615|extracellular space;","GO:0039706|co-receptor binding;GO:0048019|receptor antagonist activity;","K02165","DKK1_2_4; dickkopf 1/2/4"]
["ENSRNOG00000016872",28,2.355787522,8,0.514643505,4.57751336,2.194564097,{"v":2.92e-05,"d":"2.92E-05"},{"v":2.86e-05,"d":"2.86E-05"},"up","yes","Plppr4","protein_coding","chr2:205371322-205412302:-","gi|325197225|ref|NP_001001508.2|",3612,0,"phospholipid phosphatase-related protein type 4 [Rattus norvegicus]","gi|325197224|ref|NM_001001508.2|",4736,0,"Rattus norvegicus phospholipid phosphatase related 4 (Plppr4), mRNA","Q7TME0",1390,0,"Phospholipid phosphatase-related protein type 4",".",".",".",".","pfam01569","PAP2","PAP2 superfamily. This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidizing halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.","GO:0006644|phospholipid metabolic process;GO:0007165|signal transduction;GO:0007409|axonogenesis;GO:0046839|phospholipid dephosphorylation;GO:0048839|inner ear development;","GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0098978|glutamatergic synapse;GO:0099061|integral component of postsynaptic density membrane;","GO:0008195|phosphatidate phosphatase activity;GO:0042577|lipid phosphatase activity;GO:0052642|lysophosphatidic acid phosphatase activity;","K19582","LPPR3_4; lipid phosphate phosphatase-related protein type 3/4"]
["ENSRNOG00000015089",23,1.935111179,5,0.321652191,6.016160416,2.588843036,{"v":2.99e-05,"d":"2.99E-05"},{"v":2.93e-05,"d":"2.93E-05"},"up","yes","Mcoln2","protein_coding","chr2:235053816-235102702:+","gi|84781670|ref|NP_001034094.1|",2954,0,"mucolipin-2 [Rattus norvegicus]","gi|84781669|ref|NM_001039005.1|",2504,0,"Rattus norvegicus mucolipin 2 (Mcoln2), mRNA","Q8K595",1052,0,"Mucolipin-2",".",".",".",".","pfam08016","PKD_channel","Polycystin cation channel. This family contains the cation channel region of PKD1 and PKD2 proteins.","GO:0032722|positive regulation of chemokine production;GO:0051209|release of sequestered calcium ion into cytosol;GO:0071639|positive regulation of monocyte chemotactic protein-1 production;GO:0071642|positive regulation of macrophage inflammatory protein 1 alpha production;GO:0071651|positive regulation of chemokine (C-C motif) ligand 5 production;GO:1905517|macrophage migration;GO:1990266|neutrophil migration;GO:2000341|regulation of chemokine (C-X-C motif) ligand 2 production;GO:2000343|positive regulation of chemokine (C-X-C motif) ligand 2 production;","GO:0010008|endosome membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0055037|recycling endosome;","GO:0042802|identical protein binding;GO:0072345|NAADP-sensitive calcium-release channel activity;","K04993","MCOLN2, TRPML2; mucolipin 2"]
["ENSRNOG00000064692",15,1.26202903,1,0.064330438,19.6179144,4.29409977,{"v":3.17e-05,"d":"3.17E-05"},{"v":3.1e-05,"d":"3.10E-05"},"up","yes","Kif4b","protein_coding","chr6:120397005-120401245:+","gi|564307666|ref|XP_006225924.1|",5834,0,"PREDICTED: chromosome-associated kinesin KIF4A-like isoform X1 [Rattus norvegicus]","gi|672021055|ref|XM_006225862.2|",4145,0,"PREDICTED: Rattus norvegicus kinesin family member 4B (Kif4b), transcript variant X1, mRNA","O95239",1639,0,"Chromosome-associated kinesin KIF4A",".",".",".",".","pfam00225","Kinesin","Kinesin motor domain.",".",".",".",".","."]
["ENSRNOG00000014940",21,1.766840642,4,0.257321753,6.86627004,2.779526598,{"v":3.43E-5,"d":"3.43E-05"},{"v":3.33e-05,"d":"3.33E-05"},"up","yes","Sfrp5","protein_coding","chr1:241006762-241011224:-","gi|157821237|ref|NP_001101061.1|",1422,0,"secreted frizzled-related protein 5 precursor [Rattus norvegicus]","gi|157821236|ref|NM_001107591.1|",1989,0,"Rattus norvegicus secreted frizzled-related protein 5 (Sfrp5), mRNA","Q9WU66",546,0,"Secreted frizzled-related protein 5",".",".",".",".","pfam01392","Fz","Fz domain. Also known as the CRD (cysteine rich domain), the C6 box in MuSK receptor. This domain of unknown function has been independently identified by several groups. The domain contains 10 conserved cysteines.","GO:0008150|biological_process;GO:0008285|negative regulation of cell proliferation;GO:0030154|cell differentiation;GO:0030510|regulation of BMP signaling pathway;GO:0035567|non-canonical Wnt signaling pathway;GO:0036342|post-anal tail morphogenesis;GO:0043433|negative regulation of DNA-binding transcription factor activity;GO:0043508|negative regulation of JUN kinase activity;GO:0048546|digestive tract morphogenesis;GO:0051898|negative regulation of protein kinase B signaling;GO:0060028|convergent extension involved in axis elongation;GO:0060070|canonical Wnt signaling pathway;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0090175|regulation of establishment of planar polarity;GO:0090179|planar cell polarity pathway involved in neural tube closure;GO:2000041|negative regulation of planar cell polarity pathway involved in axis elongation;GO:2000057|negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis;","GO:0005575|cellular_component;GO:0005615|extracellular space;","GO:0003674|molecular_function;GO:0017147|Wnt-protein binding;","K02222","SFRP5; secreted frizzled-related protein 5"]
["ENSRNOG00000062621",21,1.766840642,4,0.257321753,6.86627004,2.779526598,{"v":3.43E-5,"d":"3.43E-05"},{"v":3.33e-05,"d":"3.33E-05"},"up","yes","Ly49i7","protein_coding","chr4:164853574-164867333:-","gi|57222326|ref|NP_001009500.1|",1377,0,"immunoreceptor Ly49i7 [Rattus norvegicus]","gi|672051553|ref|XM_008763440.1|",819,0,"PREDICTED: Rattus norvegicus killer cell lectin-like receptor 5-like (LOC100911272), mRNA","P20937",325,{"v":8e-110,"d":"8.00E-110"},"T-cell surface glycoprotein YE1/48",".",".",".",".","pfam08391","Ly49","Ly49-like protein, N-terminal region. The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).",".",".",".",".","."]
["ENSRNOG00000021334",52,4.37503397,26,1.672591393,2.61572192,1.387209175,{"v":3.45e-05,"d":"3.45E-05"},{"v":3.35e-05,"d":"3.35E-05"},"up","yes","Lag3","protein_coding","chr4:157712667-157720404:-","gi|61889117|ref|NP_997678.2|",2198,0,"lymphocyte activation gene 3 protein precursor [Rattus norvegicus]","gi|61889116|ref|NM_212513.2|",1790,0,"Rattus norvegicus lymphocyte activating 3 (Lag3), mRNA","Q5BK54",851,0,"Lymphocyte activation gene 3 protein",".",".",".",".","pfam13927","Ig_3","Immunoglobulin domain. This family contains immunoglobulin-like domains.","GO:0002250|adaptive immune response;GO:0002270|plasmacytoid dendritic cell activation;GO:0007166|cell surface receptor signaling pathway;GO:0032703|negative regulation of interleukin-2 production;GO:0045590|negative regulation of regulatory T cell differentiation;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;GO:0050776|regulation of immune response;GO:0050868|negative regulation of T cell activation;","GO:0005576|extracellular region;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0004888|transmembrane signaling receptor activity;GO:0042289|MHC class II protein binding;","K06565","LAG3, CD223; lymphocyte-activation gene 3 protein"]
["ENSRNOG00000030387",47,3.954357626,22,1.41526964,2.794066597,1.482366408,{"v":3.5e-05,"d":"3.50E-05"},{"v":3.39e-05,"d":"3.39E-05"},"up","yes","Kng1","protein_coding","chr11:77812752-77835555:-","gi|149019923|gb|EDL78071.1|",2354,0,"rCG36716, isoform CRA_d [Rattus norvegicus]","gi|57526867|ref|NM_001009628.1|",1285,0,"Rattus norvegicus kininogen 1-like 1 (Kng1l1), mRNA","P08934",907,0,"Kininogen-1",".",".",".",".","pfam00031","Cystatin","Cystatin domain. Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 are related to this family but have not been included.","GO:0001938|positive regulation of endothelial cell proliferation;GO:0002542|Factor XII activation;GO:0006953|acute-phase response;GO:0006954|inflammatory response;GO:0007162|negative regulation of cell adhesion;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007596|blood coagulation;GO:0010951|negative regulation of endopeptidase activity;GO:0030195|negative regulation of blood coagulation;GO:0031640|killing of cells of other organism;GO:0042130|negative regulation of T cell proliferation;GO:0042311|vasodilation;GO:0043407|negative regulation of MAP kinase activity;GO:0043410|positive regulation of MAPK cascade;GO:0045861|negative regulation of proteolysis;GO:0048146|positive regulation of fibroblast proliferation;GO:0050672|negative regulation of lymphocyte proliferation;GO:0052548|regulation of endopeptidase activity;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0043204|perikaryon;GO:0043231|intracellular membrane-bounded organelle;","GO:0002020|protease binding;GO:0004866|endopeptidase inhibitor activity;GO:0004869|cysteine-type endopeptidase inhibitor activity;GO:0005102|signaling receptor binding;","K03898","KNG, BK; kininogen"]
["ENSRNOG00000000335",19,1.598570104,3,0.192991315,8.283119414,3.050174187,{"v":3.69e-05,"d":"3.69E-05"},{"v":3.57E-5,"d":"3.57E-05"},"up","yes","Ermap","protein_coding","chr5:132789991-132802847:-","gi|672019865|ref|XP_008774301.1|",2758,0,"PREDICTED: erythroid membrane-associated protein isoform X5 [Rattus norvegicus]","gi|672019864|ref|XM_008776079.1|",2019,0,"PREDICTED: Rattus norvegicus erythroblast membrane-associated protein (Ermap), transcript variant X12, mRNA","Q9JLN5",926,0,"Erythroid membrane-associated protein",".",".",".",".","pfam13765","PRY","SPRY-associated domain. SPRY and PRY domains occur on PYRIN proteins. Their function is not known.","GO:0001817|regulation of cytokine production;GO:0050852|T cell receptor signaling pathway;","GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0031410|cytoplasmic vesicle;","GO:0005102|signaling receptor binding;","K06712","BTN, CD277; butyrophilin"]
["ENSRNOG00000017002",19,1.598570104,3,0.192991315,8.283119414,3.050174187,{"v":3.69e-05,"d":"3.69E-05"},{"v":3.57E-5,"d":"3.57E-05"},"up","yes","Adrb1","protein_coding","chr1:255771597-255807259:+","gi|220671|dbj|BAA00527.1|",1651,0,"beta-1 adrenergic receptor [Rattus norvegicus]","gi|74013488|gb|AC158549.8|",2776,0,"Mus musculus chromosome 19, clone RP24-216K4, complete sequence","P34971",638,0,"Beta-1 adrenergic receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001996|positive regulation of heart rate by epinephrine-norepinephrine;GO:0001997|positive regulation of the force of heart contraction by epinephrine-norepinephrine;GO:0002024|diet induced thermogenesis;GO:0002025|norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure;GO:0003061|positive regulation of the force of heart contraction by norepinephrine;GO:0003084|positive regulation of systemic arterial blood pressure;GO:0005980|glycogen catabolic process;GO:0006915|apoptotic process;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007266|Rho protein signal transduction;GO:0007568|aging;GO:0007613|memory;GO:0009409|response to cold;GO:0010460|positive regulation of heart rate;GO:0019233|sensory perception of pain;GO:0031649|heat generation;GO:0033365|protein localization to organelle;GO:0035811|negative regulation of urine volume;GO:0040015|negative regulation of multicellular organism growth;GO:0042060|wound healing;GO:0042596|fear response;GO:0043065|positive regulation of apoptotic process;GO:0043547|positive regulation of GTPase activity;GO:0045187|regulation of circadian sleep/wake cycle, sleep;GO:0045762|positive regulation of adenylate cyclase activity;GO:0045986|negative regulation of smooth muscle contraction;GO:0046878|positive regulation of saliva secretion;GO:0050873|brown fat cell differentiation;GO:0051924|regulation of calcium ion transport;GO:0055088|lipid homeostasis;GO:0060078|regulation of postsynaptic membrane potential;GO:0060080|inhibitory postsynaptic potential;GO:0061051|positive regulation of cell growth involved in cardiac muscle cell development;GO:0071880|adenylate cyclase-activating adrenergic receptor signaling pathway;GO:0086004|regulation of cardiac muscle cell contraction;GO:0106071|positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0120162|positive regulation of cold-induced thermogenesis;GO:1900135|positive regulation of renin secretion into blood stream;GO:1900273|positive regulation of long-term synaptic potentiation;GO:1905665|positive regulation of calcium ion import across plasma membrane;GO:2001259|positive regulation of cation channel activity;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005769|early endosome;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098794|postsynapse;","GO:0004930|G protein-coupled receptor activity;GO:0004940|beta1-adrenergic receptor activity;GO:0005085|guanyl-nucleotide exchange factor activity;GO:0005515|protein binding;GO:0030165|PDZ domain binding;GO:0031694|alpha-2A adrenergic receptor binding;GO:0043176|amine binding;GO:0046982|protein heterodimerization activity;GO:0099579|G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential;","K04141","ADRB1; adrenergic receptor beta-1"]
["ENSRNOG00000048004",26,2.187516985,7,0.450313067,4.85776928,2.280293971,{"v":3.73e-05,"d":"3.73E-05"},{"v":3.6e-05,"d":"3.60E-05"},"up","yes","Garem2","protein_coding","chr6:26230048-26241762:-","gi|300798228|ref|NP_001178803.1|",3267,0,"GRB2-associated and regulator of MAPK protein-like [Rattus norvegicus]","gi|300798227|ref|NM_001191874.1|",2662,0,"Rattus norvegicus GRB2 associated regulator of MAPK1, member 2 (Garem2), mRNA",".",".",".",".",".",".",".",".","pfam12736","CABIT","Cell-cycle sustaining, positive selection,. The 'CABIT' domain (for 'cysteine-containing, all- in Themis') is found in a newly identified gene family that has three mammalian homologues (Themis, Icb1 and 9130404H23Rik) that encode proteins with two CABIT domains and a highly conserved proline-rich region. In contrast, Fam59A, Fam59B and related proteins from mammals to cnidarians, including the insect Serrano proteins, have a single copy of the CABIT domain, a proline-rich region and often a C-terminal SAM (sterile-motif) domain. Multiple-sequence alignment has predicted that the CABIT domain adopts an all-strand structure with at least 12 strands, ie a dyad of six-stranded beta-barrel units. The CABIT domain contains a nearly absolutely conserved cysteine residue which is likely to be central to its function. CABIT domain proteins function downstream of tyrosine kinase signalling and interact with GRB2.",".",".",".",".","."]
["ENSRNOG00000067449",43,3.617816552,19,1.222278326,2.959895857,1.565546416,{"v":3.78e-05,"d":"3.78E-05"},{"v":3.64e-05,"d":"3.64E-05"},"up","yes","ENSRNOG00000067449","lncRNA","chr10:104292395-104293585:-",".",".",".",".","gi|26342293|dbj|AK051905.1|",861,0,"Mus musculus 12 days embryo eyeball cDNA, RIKEN full-length enriched library, clone:D230017K24 product:chromobox homolog 8 (Drosophila Pc class), full insert sequence",".",".",".",".",".",".",".",".","pfam15301","SLAIN","SLAIN motif-containing family. The SLAIN motif containing family is named after the presence of a SLAIN motif in SLAIN1. They are a family of microtubule plus-end tracking proteins.",".",".",".",".","."]
["ENSRNOG00000025460",32,2.692328597,11,0.70763482,3.804686429,1.927777556,{"v":3.94e-05,"d":"3.94E-05"},{"v":3.79E-5,"d":"3.79E-05"},"up","yes","Tmem71","protein_coding","chr7:98276975-98315858:-","gi|403420582|ref|NP_001258144.1|",1268,{"v":1E-165,"d":"1.00E-165"},"transmembrane protein 71 [Rattus norvegicus]","gi|403420581|ref|NM_001271215.1|",1206,0,"Rattus norvegicus transmembrane protein 71 (Tmem71), mRNA","Q149F5",449,{"v":3e-150,"d":"3.00E-150"},"Transmembrane protein 71",".",".",".",".","pfam15121","TMEM71","TMEM71 protein family. The function of this family, TMEM71, is not known, however it is predicted to be a transmembrane protein. This family of proteins is found in eukaryotes and located in the cell membrane. Proteins in this family vary between 41 and 291 amino acids in length.",".","GO:0005739|mitochondrion;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000069032",67,5.637062999,39,2.508887089,2.24683806,1.167896146,{"v":3.94e-05,"d":"3.94E-05"},{"v":3.79E-5,"d":"3.79E-05"},"up","yes","ENSRNOG00000069032","protein_coding","chr7:109179359-109187093:-","gi|149066036|gb|EDM15909.1|",1453,0,"rCG65936 [Rattus norvegicus]","gi|298906619|emb|FQ225154.1|",1351,0,"Rattus norvegicus TL0AEA54YP09 mRNA sequence","O95236",184,{"v":3E-51,"d":"3.00E-51"},"Apolipoprotein L3",".",".",".",".","pfam05461","ApoL","Apolipoprotein L. Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.",".",".",".",".","."]
["ENSRNOG00000023937",49,4.122628164,24,1.543930516,2.670216127,1.416956518,{"v":4.4e-05,"d":"4.40E-05"},{"v":4.22e-05,"d":"4.22E-05"},"up","yes","Slc49a3","protein_coding","chr14:1305680-1314132:+","gi|157822105|ref|NP_001100716.1|",2287,0,"major facilitator superfamily domain-containing protein 7 [Rattus norvegicus]","gi|157822104|ref|NM_001107246.1|",2733,0,"Rattus norvegicus major facilitator superfamily domain containing 7 (Mfsd7), mRNA","Q8CE47",807,0,"Solute carrier family 49 member A3",".",".",".",".","pfam07690","MFS_1","Major Facilitator Superfamily.","GO:0055085|transmembrane transport;","GO:0016021|integral component of membrane;","GO:0022857|transmembrane transporter activity;","K12306","MSFD7, SLC49A4; MFS transporter, FLVCR family, MFS-domain-containing protein 7"]
["ENSRNOG00000015253",70,5.889468805,42,2.701878404,2.179768267,1.124174769,{"v":4.59e-05,"d":"4.59E-05"},{"v":4.38e-05,"d":"4.38E-05"},"up","yes","Hsf4","protein_coding","chr19:33147755-33153479:+","gi|564395446|ref|XP_006255515.1|",2331,0,"PREDICTED: heat shock factor protein 4 isoform X1 [Rattus norvegicus]","gi|672084750|ref|XM_006255453.2|",1705,0,"PREDICTED: Rattus norvegicus heat shock transcription factor 4 (Hsf4), transcript variant X1, mRNA","Q9R0L1",861,0,"Heat shock factor protein 4","SPAC2E12.02.02",125,{"v":1e-29,"d":"1.00E-29"},"COG5169","pfam00447","HSF_DNA-bind","HSF-type DNA-binding.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001654|eye development;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007601|visual perception;GO:0008284|positive regulation of cell proliferation;GO:0033169|histone H3-K9 demethylation;GO:0043010|camera-type eye development;GO:0045597|positive regulation of cell differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048468|cell development;","GO:0000785|chromatin;GO:0005634|nucleus;GO:0016607|nuclear speck;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0019903|protein phosphatase binding;GO:0042802|identical protein binding;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09417","HSF4; heat shock transcription factor 4"]
["ENSRNOG00000005558",64,5.384657193,37,2.380226213,2.262245985,1.177755809,{"v":5.23e-05,"d":"5.23E-05"},{"v":4.96e-05,"d":"4.96E-05"},"up","yes","ENSRNOG00000005558","protein_coding","chr13:104692824-104695470:+","gi|157073947|ref|NP_001096827.1|",1376,0,"UPF0739 protein C1orf74 homolog [Rattus norvegicus]","gi|157073946|ref|NM_001103357.1|",1970,0,"Rattus norvegicus hypothetical protein LOC100125367 (LOC100125367), mRNA",".",".",".",".",".",".",".",".","pfam14953","DUF4504","Domain of unknown function (DUF4504). This family of proteins is found in eukaryotes. Proteins in this family are typically between 253 and 329 amino acids in length. There are two conserved sequence motifs: LLGYP and SFS.",".",".",".",".","."]
["ENSRNOG00000000825",22,1.85097591,5,0.321652191,5.754588224,2.524712698,{"v":5.69e-05,"d":"5.69E-05"},{"v":5.35e-05,"d":"5.35E-05"},"up","yes","Calhm5","protein_coding","chr20:26066242-26072272:-","gi|68163381|ref|NP_001020148.1|",1650,0,"protein FAM26E [Rattus norvegicus]","gi|68163380|ref|NM_001024977.1|",1024,0,"Rattus norvegicus family with sequence similarity 26, member E (Fam26e), mRNA","Q5FWS4",640,0,"Calcium homeostasis modulator protein 5",".",".",".",".","pfam14798","Ca_hom_mod","Calcium homeostasis modulator. This family of proteins control cytosolic calcium concentration. They are transmembrane proteins which may be pore-forming ion channels.","GO:0098655|cation transmembrane transport;","GO:0005887|integral component of plasma membrane;","GO:0005261|cation channel activity;",".","."]
["ENSRNOG00000070111",22,1.85097591,5,0.321652191,5.754588224,2.524712698,{"v":5.69e-05,"d":"5.69E-05"},{"v":5.35e-05,"d":"5.35E-05"},"up","yes","Apol2","protein_coding","chr7:109331392-109338558:-","gi|392341617|ref|XP_001075828.3|",1457,0,"PREDICTED: apolipoprotein L2 isoform X2 [Rattus norvegicus]","gi|672060336|ref|XM_006241955.2|",2016,0,"PREDICTED: Rattus norvegicus apolipoprotein L3-like (LOC100911804), transcript variant X6, mRNA","Q9BQE5",167,{"v":2e-43,"d":"2.00E-43"},"Apolipoprotein L2",".",".",".",".","pfam05461","ApoL","Apolipoprotein L. Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.",".",".",".",".","."]
["ENSRNOG00000067887",52,4.37503397,27,1.736921831,2.518843331,1.332761391,{"v":5.91E-5,"d":"5.91E-05"},{"v":5.55e-05,"d":"5.55E-05"},"up","yes","ENSRNOG00000067887","lncRNA","chr7:12622899-12623905:+",".",".",".",".","gi|195540031|gb|BC168190.1|",939,0,"Rattus norvegicus cDNA clone IMAGE:7106560",".",".",".",".",".",".",".",".","pfam07778","CENP-I","Mis6. Mis6 is an essential centromere connector protein acting during G1-S phase of the cell cycle. Mis6 is thought to be required for recruiting CENP-A, the centromere- specific histone H3 variant, an important event for centromere function and chromosome segregation during mitosis.",".",".",".",".","."]
["ENSRNOG00000021086",77,6.478415686,49,3.152191471,2.05521008,1.039285871,{"v":6.07e-05,"d":"6.07E-05"},{"v":5.69e-05,"d":"5.69E-05"},"up","yes","Dtx4","protein_coding","chr1:209460735-209492818:-","gi|188219611|ref|NP_766030.3|",2908,0,"E3 ubiquitin-protein ligase DTX4 [Mus musculus]","gi|672039832|ref|XM_006231114.2|",1735,0,"PREDICTED: Rattus norvegicus deltex 4, E3 ubiquitin ligase (Dtx4), transcript variant X1, mRNA","Q6PDK8",1124,0,"E3 ubiquitin-protein ligase DTX4",".",".",".",".","pfam02825","WWE","WWE domain. The WWE domain is named after three of its conserved residues and is predicted to mediate specific protein- protein interactions in ubiquitin and ADP ribose conjugation systems.","GO:0007219|Notch signaling pathway;GO:0016567|protein ubiquitination;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;","GO:0008270|zinc ion binding;GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;","K06058","DTX; deltex [EC:2.3.2.27]"]
["ENSRNOG00000016627",78,6.562550954,50,3.216521909,2.040263098,1.028755204,{"v":6.27e-05,"d":"6.27E-05"},{"v":5.86e-05,"d":"5.86E-05"},"up","yes","Eya4","protein_coding","chr1:22172275-22415976:+","gi|404434382|ref|NP_001258246.1|",2912,0,"eyes absent homolog 4 [Rattus norvegicus]","gi|755532781|ref|XM_011243111.1|",3927,0,"PREDICTED: Mus musculus eyes absent 4 homolog (Drosophila) (Eya4), transcript variant X1, mRNA","Q9Z191",1117,0,"Eyes absent homolog 4",".",".",".",".","pfam07223","DUF1421","Protein of unknown function (DUF1421). This family represents a conserved region approximately 350 residues long within a number of plant proteins of unknown function.","GO:0006281|DNA repair;GO:0007605|sensory perception of sound;GO:0016576|histone dephosphorylation;GO:0030154|cell differentiation;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0042474|middle ear morphogenesis;GO:0045739|positive regulation of DNA repair;GO:0048839|inner ear development;GO:0048856|anatomical structure development;GO:2001240|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0004725|protein tyrosine phosphatase activity;GO:0046872|metal ion binding;","K17622","EYA4; eyes absent homolog 4 [EC:3.1.3.48]"]
["ENSRNOG00000012390",38,3.197140209,16,1.029287011,3.10616978,1.635136688,{"v":6.4e-05,"d":"6.40E-05"},{"v":5.98e-05,"d":"5.98E-05"},"up","yes","Npw","protein_coding","chr10:13680321-13681586:-","gi|23463263|ref|NP_695206.1|",757,{"v":9e-99,"d":"9.00E-99"},"neuropeptide W precursor [Rattus norvegicus]","gi|23463262|ref|NM_153294.1|",684,0,"Rattus norvegicus neuropeptide W (Npw), mRNA","Q8K1M5",296,{"v":3e-100,"d":"3.00E-100"},"Neuropeptide W",".",".",".",".","pfam15180","NPBW","Neuropeptides B and W. The function of this family, NPBW, which includes Neuropeptides B and W, is thought to be involved in activating G-protein coupled receptors, GPR7 and GPR8. It is thought to play a regulatory role in the organisation of neuroendocrine signals accessing the anterior pituitary gland. It is predicted that this effect will stimulate the increase in water-drinking and food-intake. This suggests it plays a role in the hypothalamic response to stress. This family of proteins is found in eukaryotes.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0007218|neuropeptide signaling pathway;GO:0007631|feeding behavior;","GO:0005576|extracellular region;","GO:0001664|G protein-coupled receptor binding;","K23141","NPW; neuropeptide W"]
["ENSRNOG00000014683",14,1.177893761,1,0.064330438,18.31005344,4.194564097,{"v":6.48e-05,"d":"6.48E-05"},{"v":6.05E-5,"d":"6.05E-05"},"up","yes","Il1rl2","protein_coding","chr9:42591934-42636667:+","gi|149046283|gb|EDL99176.1|",2955,0,"interleukin 1 receptor-like 2, isoform CRA_a [Rattus norvegicus]","gi|19424265|ref|NM_133575.1|",2027,0,"Rattus norvegicus interleukin 1 receptor-like 2 (Il1rl2), mRNA","Q62929",1135,0,"Interleukin-1 receptor-like 2",".",".",".",".","pfam01582","TIR","TIR domain. The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.","GO:0019221|cytokine-mediated signaling pathway;GO:0032755|positive regulation of interleukin-6 production;GO:0045582|positive regulation of T cell differentiation;GO:0050727|regulation of inflammatory response;","GO:0016021|integral component of membrane;","GO:0003953|NAD+ nucleosidase activity;GO:0004908|interleukin-1 receptor activity;GO:0050135|NAD(P)+ nucleosidase activity;GO:0061809|NAD+ nucleotidase, cyclic ADP-ribose generating;","K05172","IL1RL2, IL1RRP2; interleukin 1 receptor-like 2"]
["ENSRNOG00000067780",14,1.177893761,1,0.064330438,18.31005344,4.194564097,{"v":6.48e-05,"d":"6.48E-05"},{"v":6.05E-5,"d":"6.05E-05"},"up","yes","ENSRNOG00000067780","lncRNA","chr1:80724326-80747150:+",".",".",".",".","gi|672035472|ref|XR_590093.1|",1771,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103691054 (LOC103691054), ncRNA",".",".",".",".",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.",".",".",".",".","."]
["ENSRNOG00000026679",54,4.543304507,29,1.865582707,2.435327305,1.284115682,{"v":6.98e-05,"d":"6.98E-05"},{"v":6.49e-05,"d":"6.49E-05"},"up","yes","Scn4b","protein_coding","chr8:45446215-45462292:+","gi|57114338|ref|NP_001008880.1|",856,{"v":5e-101,"d":"5.00E-101"},"sodium channel subunit beta-4 precursor [Rattus norvegicus]","gi|57114337|ref|NM_001008880.1|",4192,0,"Rattus norvegicus sodium voltage-gated channel beta subunit 4 (Scn4b), mRNA","Q7M730",334,{"v":2e-102,"d":"2.00E-102"},"Sodium channel subunit beta-4",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0006814|sodium ion transport;GO:0008150|biological_process;GO:0010765|positive regulation of sodium ion transport;GO:0035725|sodium ion transmembrane transport;GO:0060048|cardiac muscle contraction;GO:0060307|regulation of ventricular cardiac muscle cell membrane repolarization;GO:0086002|cardiac muscle cell action potential involved in contraction;GO:0086012|membrane depolarization during cardiac muscle cell action potential;GO:0086016|AV node cell action potential;GO:0086091|regulation of heart rate by cardiac conduction;GO:2000649|regulation of sodium ion transmembrane transporter activity;","GO:0001518|voltage-gated sodium channel complex;GO:0005886|plasma membrane;GO:0014704|intercalated disc;GO:0031226|intrinsic component of plasma membrane;","GO:0003674|molecular_function;GO:0005244|voltage-gated ion channel activity;GO:0005248|voltage-gated sodium channel activity;GO:0017080|sodium channel regulator activity;GO:0044325|ion channel binding;GO:0086006|voltage-gated sodium channel activity involved in cardiac muscle cell action potential;","K04848","SCN4B; voltage-gated sodium channel type IV beta"]
["ENSRNOG00000069732",43,3.617816552,20,1.286608764,2.811901064,1.491545835,{"v":6.99e-05,"d":"6.99E-05"},{"v":6.5e-05,"d":"6.50E-05"},"up","yes","ENSRNOG00000069732","lncRNA","chr7:130056833-130058256:-","gi|148692777|gb|EDL24724.1|",138,{"v":2e-07,"d":"2.00E-07"},"interleukin 17 receptor D [Mus musculus]","gi|37202204|gb|AC115751.6|",87,{"v":2E-35,"d":"2.00E-35"},"Mus musculus chromosome 1, clone RP23-16I21, complete sequence",".",".",".",".",".",".",".",".","pfam00517","GP41","Retroviral envelope protein. This family includes envelope protein from a variety of retroviruses. It includes the GP41 subunit of the envelope protein complex from human and simian immunodeficiency viruses (HIV and SIV) which mediate membrane fusion during viral entry. The family also includes bovine immunodeficiency virus, feline immunodeficiency virus and Equine infectious anaemia (EIAV). The family also includes the Gp36 protein from mouse mammary tumor virus (MMTV) and human endogenous retroviruses (HERVs).",".",".",".",".","."]
["ENSRNOG00000004794",70,5.889468805,43,2.766208842,2.129075982,1.090227437,{"v":7.02e-05,"d":"7.02E-05"},{"v":6.52e-05,"d":"6.52E-05"},"up","yes","Rtn1","protein_coding","chr6:90763216-90983436:-","gi|16758732|ref|NP_446317.1|",3344,0,"reticulon-1 [Rattus norvegicus]","gi|16758731|ref|NM_053865.1|",3449,0,"Rattus norvegicus reticulon 1 (Rtn1), mRNA","Q64548",1292,0,"Reticulon-1",".",".",".",".","pfam02453","Reticulon","Reticulon. Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of unknown function which associates with the endoplasmic reticulum. This family represents the C-terminal domain of the three reticulon isoforms and their homologues.","GO:0030182|neuron differentiation;GO:1902430|negative regulation of amyloid-beta formation;","GO:0000139|Golgi membrane;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005790|smooth endoplasmic reticulum;GO:0016021|integral component of membrane;",".","K20721","RTN1; reticulon-1"]
["ENSRNOG00000043203",16,1.346164298,2,0.128660876,10.46288768,3.387209175,{"v":7.3e-05,"d":"7.30E-05"},{"v":6.77e-05,"d":"6.77E-05"},"up","yes","Krt75","protein_coding","chr7:132688237-132697345:-","gi|148672089|gb|EDL04036.1|",2007,0,"keratin 75, partial [Mus musculus]","gi|672059945|ref|XM_006242325.2|",2159,0,"PREDICTED: Rattus norvegicus keratin 75 (Krt75), transcript variant X1, mRNA","Q6IG05",766,0,"Keratin, type II cytoskeletal 75",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0002244|hematopoietic progenitor cell differentiation;","GO:0005882|intermediate filament;GO:0045095|keratin filament;",".","K07605","KRT2; type II keratin, basic"]
["ENSRNOG00000026310",39,3.281275477,17,1.093617449,3.000386908,1.585148552,{"v":7.49e-05,"d":"7.49E-05"},{"v":6.94e-05,"d":"6.94E-05"},"up","yes","Marchf1","protein_coding","chr16:23258799-24114277:-","gi|829901937|ref|XP_012591030.1|",2034,0,"PREDICTED: E3 ubiquitin-protein ligase MARCH1 isoform X1 [Microcebus murinus]","gi|755526033|ref|XM_006509754.2|",1608,0,"PREDICTED: Mus musculus membrane-associated ring finger (C3HC4) 1 (March1), transcript variant X1, mRNA","Q6NZQ8",449,{"v":2e-148,"d":"2.00E-148"},"E3 ubiquitin-protein ligase MARCH1","SPBC14F5.07",75.5,{"v":7e-13,"d":"7.00E-13"},"COG5183","pfam12906","RINGv","RING-variant domain.","GO:0000209|protein polyubiquitination;GO:0002495|antigen processing and presentation of peptide antigen via MHC class II;GO:0006955|immune response;","GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0005765|lysosomal membrane;GO:0005768|endosome;GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0031901|early endosome membrane;GO:0031902|late endosome membrane;GO:0032588|trans-Golgi network membrane;","GO:0004842|ubiquitin-protein transferase activity;GO:0008270|zinc ion binding;GO:0042287|MHC protein binding;GO:0061630|ubiquitin protein ligase activity;","K10656","MARCH1_8; E3 ubiquitin-protein ligase MARCH1/8 [EC:2.3.2.27]"]
["ENSRNOG00000005286",44,3.70195182,21,1.350939202,2.740280107,1.454323371,{"v":7.89e-05,"d":"7.89E-05"},{"v":7.28e-05,"d":"7.28E-05"},"up","yes","Coch","protein_coding","chr6:69031167-69045109:+","gi|149051203|gb|EDM03376.1|",2785,0,"coagulation factor C homolog (Limulus polyphemus) (predicted), isoform CRA_a [Rattus norvegicus]","gi|169642482|gb|BC160874.1|",2292,0,"Rattus norvegicus coagulation factor C homolog, cochlin (Limulus polyphemus), mRNA (cDNA clone MGC:188242 IMAGE:7367398), complete cds","Q62507",1066,0,"Cochlin",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0007605|sensory perception of sound;GO:0008150|biological_process;GO:0008360|regulation of cell shape;GO:0042742|defense response to bacterium;GO:0045089|positive regulation of innate immune response;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0031012|extracellular matrix;GO:0062023|collagen-containing extracellular matrix;","GO:0003674|molecular_function;GO:0005518|collagen binding;",".","."]
["ENSRNOG00000065945",32,2.692328597,12,0.771965258,3.487629227,1.802246674,{"v":8.57e-05,"d":"8.57E-05"},{"v":7.87e-05,"d":"7.87E-05"},"up","yes","ENSRNOG00000065945","lncRNA","chr5:160567024-160568342:-",".",".",".",".","gi|354795025|gb|JN959526.1|",327,{"v":5e-169,"d":"5.00E-169"},"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Gpr157:tm1e(KOMP)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSRNOG00000011921",65,5.468792462,39,2.508887089,2.179768267,1.124174769,{"v":8.59e-05,"d":"8.59E-05"},{"v":7.89e-05,"d":"7.89E-05"},"up","yes","Dusp4","protein_coding","chr16:57377229-57398138:-","gi|149057945|gb|EDM09188.1|",1942,0,"dual specificity phosphatase 4 [Rattus norvegicus]","gi|142364920|ref|NM_176933.4|",1445,0,"Mus musculus dual specificity phosphatase 4 (Dusp4), mRNA","Q62767",752,0,"Dual specificity protein phosphatase 4","SPBC17A3.06",74.7,{"v":3e-13,"d":"3.00E-13"},"COG2453","pfam00782","DSPc","Dual specificity phosphatase, catalytic domain. Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a \"recognition\" region.","GO:0001706|endoderm formation;GO:0006470|protein dephosphorylation;GO:0016311|dephosphorylation;GO:0035335|peptidyl-tyrosine dephosphorylation;GO:0043409|negative regulation of MAPK cascade;GO:0070373|negative regulation of ERK1 and ERK2 cascade;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;","GO:0004721|phosphoprotein phosphatase activity;GO:0004725|protein tyrosine phosphatase activity;GO:0008330|protein tyrosine/threonine phosphatase activity;GO:0016791|phosphatase activity;GO:0017017|MAP kinase tyrosine/serine/threonine phosphatase activity;GO:1990439|MAP kinase serine/threonine phosphatase activity;","K04459","DUSP, MKP; dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48]"]
["ENSRNOG00000019659",57,4.795710313,32,2.058574022,2.329627335,1.220099189,{"v":8.65e-05,"d":"8.65E-05"},{"v":7.94e-05,"d":"7.94E-05"},"up","yes","Aspa","protein_coding","chr10:57892104-57945272:-","gi|564372983|ref|XP_006246880.1|",1340,{"v":9e-172,"d":"9.00E-172"},"PREDICTED: aspartoacylase isoform X3 [Rattus norvegicus]","gi|104294891|gb|AC127738.4|",2831,0,"Rattus norvegicus BAC CH230-183I4 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q9R1T5",518,{"v":9e-172,"d":"9.00E-172"},"Aspartoacylase","alr3912",147,{"v":2e-37,"d":"2.00E-37"},"COG2988","pfam04952","AstE_AspA","Succinylglutamate desuccinylase / Aspartoacylase family. This family includes Succinylglutamate desuccinylase EC:3.1.-.- that catalyses the fifth and last step in arginine catabolism by the arginine succinyltransferase pathway. The family also include aspartoacylase EC:3.5.1.15 which cleaves acylaspartate into a fatty acid and aspartate. Mutations in human ASPA lead to Canavan disease disease. This family is probably structurally related to pfam00246 (Bateman A pers. obs.).","GO:0022010|central nervous system myelination;GO:0048714|positive regulation of oligodendrocyte differentiation;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0016788|hydrolase activity, acting on ester bonds;GO:0016811|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides;GO:0019807|aspartoacylase activity;GO:0042802|identical protein binding;GO:0046872|metal ion binding;","K01437","ASPA, aspA; aspartoacylase [EC:3.5.1.15]"]
["ENSRNOG00000025735",77,6.478415686,50,3.216521909,2.014105879,1.010139526,{"v":8.95e-05,"d":"8.95E-05"},{"v":8.19e-05,"d":"8.19E-05"},"up","yes","ENSRNOG00000025735","protein_coding","chr4:10424008-10441465:+","gi|124517674|ref|NP_001074910.1|",1842,0,"WD repeat-containing protein 86 [Mus musculus]","gi|160333174|ref|NM_001110489.1|",1148,0,"Rattus norvegicus WD repeat domain 86 (Wdr86), mRNA",".",".",".",".",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.",".",".",".",".","."]
["ENSRNOG00000019024",29,2.439922791,10,0.643304382,3.792796784,1.923262075,{"v":9.33e-05,"d":"9.33E-05"},{"v":8.52e-05,"d":"8.52E-05"},"up","yes","Trim67","protein_coding","chr19:52764387-52800422:+","gi|208973282|ref|NP_001129187.1|",3505,0,"tripartite motif-containing protein 67 [Rattus norvegicus]","gi|208973281|ref|NM_001135715.1|",2764,0,"Rattus norvegicus tripartite motif-containing 67 (Trim67), mRNA","Q505D9",1320,0,"Tripartite motif-containing protein 67",".",".",".",".","pfam00622","SPRY","SPRY domain. SPRY Domain is named from SPla and the RYanodine Receptor. Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.","GO:0010976|positive regulation of neuron projection development;GO:0046580|negative regulation of Ras protein signal transduction;GO:2000060|positive regulation of ubiquitin-dependent protein catabolic process;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;","GO:0008270|zinc ion binding;","K10649","TRIM9_67; tripartite motif-containing protein 9/67"]
["ENSRNOG00000018485",46,3.870222358,23,1.479600078,2.61572192,1.387209175,{"v":9.81e-05,"d":"9.81E-05"},{"v":8.93e-05,"d":"8.93E-05"},"up","yes","Gpr155","protein_coding","chr3:58216423-58270275:-","gi|157821855|ref|NP_001101281.1|",4064,0,"integral membrane protein GPR155 [Rattus norvegicus]","gi|157821854|ref|NM_001107811.1|",4810,0,"Rattus norvegicus G protein-coupled receptor 155 (Gpr155), mRNA","Q7Z3F1",1402,0,"Integral membrane protein GPR155",".",".",".",".","pfam03547","Mem_trans","Membrane transport protein. This family includes auxin efflux carrier proteins and other transporter proteins from all domains of life.","GO:0035556|intracellular signal transduction;GO:0050890|cognition;GO:0055085|transmembrane transport;","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000016041",69,5.805333537,43,2.766208842,2.09866061,1.069468877,1.01889E-4,{"v":9.25e-05,"d":"9.25E-05"},"up","yes","Zc3h12d","protein_coding","chr1:2314324-2348819:+","gi|157818857|ref|NP_001100939.1|",2636,0,"probable ribonuclease ZC3H12D [Rattus norvegicus]","gi|157818856|ref|NM_001107469.1|",3691,0,"Rattus norvegicus zinc finger CCCH type containing 12D (Zc3h12d), mRNA","Q8BIY3",858,0,"Probable ribonuclease ZC3H12D",".",".",".",".","pfam11977","RNase_Zc3h12a","Zc3h12a-like Ribonuclease NYN domain. This domain is found in the Zc3h12a protein which has shown to be a ribonuclease that controls the stability of a set of inflammatory genes. It has been suggested that this domain belongs to the PIN domain superfamily. This domain has also been identified as part of the NYN domain family.","GO:0006402|mRNA catabolic process;GO:0030308|negative regulation of cell growth;GO:0042130|negative regulation of T cell proliferation;GO:0061158|3'-UTR-mediated mRNA destabilization;GO:0090502|RNA phosphodiester bond hydrolysis, endonucleolytic;GO:2000134|negative regulation of G1/S transition of mitotic cell cycle;","GO:0000932|P-body;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0036464|cytoplasmic ribonucleoprotein granule;","GO:0003729|mRNA binding;GO:0004521|endoribonuclease activity;GO:0046872|metal ion binding;","K18668","ZC3H12, MCPIP; ribonuclease ZC3H12 [EC:3.1.-.-]"]
["ENSRNOG00000011702",33,2.776463865,13,0.836295696,3.319954745,1.731163576,0.000104914,{"v":9.51e-05,"d":"9.51E-05"},"up","yes","ENSRNOG00000011702","protein_coding","chrX:14908494-14923838:-","gi|157818139|ref|NP_001101720.1|",1749,0,"forkhead box protein P3 [Rattus norvegicus]","gi|157818138|ref|NM_001108250.1|",3185,0,"Rattus norvegicus forkhead box P3 (Foxp3), mRNA","Q99JB6",645,0,"Forkhead box protein P3","YCR065w",83.2,{"v":2e-15,"d":"2.00E-15"},"COG5025","pfam00250","Fork_head","Fork head domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001782|B cell homeostasis;GO:0001818|negative regulation of cytokine production;GO:0002262|myeloid cell homeostasis;GO:0002361|CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0002456|T cell mediated immunity;GO:0002507|tolerance induction;GO:0002513|tolerance induction to self antigen;GO:0002637|regulation of immunoglobulin production;GO:0002666|positive regulation of T cell tolerance induction;GO:0002667|regulation of T cell anergy;GO:0002669|positive regulation of T cell anergy;GO:0002677|negative regulation of chronic inflammatory response;GO:0002725|negative regulation of T cell cytokine production;GO:0002851|positive regulation of peripheral T cell tolerance induction;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008285|negative regulation of cell proliferation;GO:0009314|response to radiation;GO:0009615|response to virus;GO:0010467|gene expression;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0014045|establishment of endothelial blood-brain barrier;GO:0031064|negative regulation of histone deacetylation;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0032496|response to lipopolysaccharide;GO:0032689|negative regulation of interferon-gamma production;GO:0032693|negative regulation of interleukin-10 production;GO:0032700|negative regulation of interleukin-17 production;GO:0032703|negative regulation of interleukin-2 production;GO:0032713|negative regulation of interleukin-4 production;GO:0032714|negative regulation of interleukin-5 production;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032753|positive regulation of interleukin-4 production;GO:0032792|negative regulation of CREB transcription factor activity;GO:0032831|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0032914|positive regulation of transforming growth factor beta1 production;GO:0033092|positive regulation of immature T cell proliferation in thymus;GO:0035066|positive regulation of histone acetylation;GO:0035067|negative regulation of histone acetylation;GO:0042110|T cell activation;GO:0042130|negative regulation of T cell proliferation;GO:0043433|negative regulation of DNA-binding transcription factor activity;GO:0045591|positive regulation of regulatory T cell differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048294|negative regulation of isotype switching to IgE isotypes;GO:0048302|regulation of isotype switching to IgG isotypes;GO:0050672|negative regulation of lymphocyte proliferation;GO:0050687|negative regulation of defense response to virus;GO:0050728|negative regulation of inflammatory response;GO:0050777|negative regulation of immune response;GO:0050852|T cell receptor signaling pathway;GO:1901355|response to rapamycin;GO:2000320|negative regulation of T-helper 17 cell differentiation;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0003714|transcription corepressor activity;GO:0035035|histone acetyltransferase binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0042826|histone deacetylase binding;GO:0043565|sequence-specific DNA binding;GO:0046872|metal ion binding;GO:0051525|NFAT protein binding;GO:1990837|sequence-specific double-stranded DNA binding;","K10163","FOXP3, IPEX; forkhead box P3"]
["ENSRNOG00000058615",33,2.776463865,13,0.836295696,3.319954745,1.731163576,0.000104914,{"v":9.51e-05,"d":"9.51E-05"},"up","yes","U6","snRNA","chr1:181153246-181153352:-","gi|686705190|ref|XP_009231420.1|",124,{"v":9e-08,"d":"9.00E-08"},"PREDICTED: actin, alpha skeletal muscle-like [Pongo abelii]",".",".",".",".",".",".",".",".",".",".",".",".","pfam06750","DiS_P_DiS","Bacterial Peptidase A24 N-terminal domain. This family is found at the N-terminus of the pre-pilin peptidases (pfam01478). It's function has not been specifically determined; however some of the family have been characterized as bifunctional, and this domain may contain the N-methylation activity (EC:2.1.1.-). It consists of an intracellular region between a pair of transmembrane. This region contains an invariant proline and two almost fully conserved disulphide bridges - hence the name DiS-P-DiS. The cysteines have been shown to be essential to the overall function of the enzyme in, but their role was incorrectly ascribed.",".",".",".",".","."]
["ENSRNOG00000025332",42,3.533681283,20,1.286608764,2.746508016,1.457598503,1.11826E-4,1.00991E-4,"up","yes","Cd109","protein_coding","chr8:79454480-79569194:+","gi|392342020|ref|XP_003754487.1|",7420,0,"PREDICTED: CD109 antigen [Rattus norvegicus]","gi|672062623|ref|XM_003750546.3|",4973,0,"PREDICTED: Rattus norvegicus CD109 molecule (Cd109), mRNA","Q8R422",2328,0,"CD109 antigen",".",".",".",".","pfam07678","A2M_comp","A-macroglobulin complement component. This family includes the complement components region of the alpha-2-macroglobulin family.","GO:0001933|negative regulation of protein phosphorylation;GO:0001942|hair follicle development;GO:0010839|negative regulation of keratinocyte proliferation;GO:0010951|negative regulation of endopeptidase activity;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0045616|regulation of keratinocyte differentiation;GO:0061045|negative regulation of wound healing;GO:0072675|osteoclast fusion;","GO:0005615|extracellular space;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0004867|serine-type endopeptidase inhibitor activity;GO:0050431|transforming growth factor beta binding;","K06530","CD109; CD109 antigen"]
["ENSRNOG00000006579",62,5.216386656,37,2.380226213,2.191550798,1.131952119,0.00011484,0.00010337,"up","yes","Reg3g","protein_coding","chr4:110924168-110926723:-","gi|672050048|ref|XP_008761241.1|",871,{"v":5e-115,"d":"5.00E-115"},"PREDICTED: regenerating islet-derived protein 3-gamma isoform X1 [Rattus norvegicus]","gi|27465526|ref|NM_173097.1|",773,0,"Rattus norvegicus regenerating family member 3 gamma (Reg3g), mRNA","P42854",324,{"v":4e-111,"d":"4.00E-111"},"Regenerating islet-derived protein 3-gamma",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0002755|MyD88-dependent toll-like receptor signaling pathway;GO:0006953|acute-phase response;GO:0008284|positive regulation of cell proliferation;GO:0009617|response to bacterium;GO:0010838|positive regulation of keratinocyte proliferation;GO:0043434|response to peptide hormone;GO:0044278|cell wall disruption in other organism;GO:0045617|negative regulation of keratinocyte differentiation;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:0051838|cytolysis by host of symbiont cells;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0090303|positive regulation of wound healing;","GO:0005615|extracellular space;GO:0030141|secretory granule;","GO:0038023|signaling receptor activity;GO:0042834|peptidoglycan binding;GO:0070492|oligosaccharide binding;",".","."]
["ENSRNOG00000024230",27,2.271652253,9,0.578973944,3.92358288,1.972171675,0.000126283,1.13072E-4,"up","yes","Tnfaip8l3","protein_coding","chr8:54414457-54500079:-","gi|880879841|ref|XP_005069605.2|",1170,{"v":8e-156,"d":"8.00E-156"},"PREDICTED: LOW QUALITY PROTEIN: tumor necrosis factor alpha-induced protein 8-like protein 3 [Mesocricetus auratus]","gi|672022818|ref|XM_006226402.2|",1218,0,"PREDICTED: Rattus norvegicus tumor necrosis factor, alpha-induced protein 8-like 3 (Tnfaip8l3), transcript variant X2, mRNA","Q3TBL6",412,{"v":1E-142,"d":"1.00E-142"},"Tumor necrosis factor alpha-induced protein 8-like protein 3",".",".",".",".","pfam05527","DUF758","Domain of unknown function (DUF758). Family of eukaryotic proteins with unknown function, which are induced by tumor necrosis factor.","GO:0015914|phospholipid transport;GO:0019216|regulation of lipid metabolic process;GO:0042981|regulation of apoptotic process;GO:0043552|positive regulation of phosphatidylinositol 3-kinase activity;GO:0048017|inositol lipid-mediated signaling;GO:0051897|positive regulation of protein kinase B signaling;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0120009|intermembrane lipid transfer;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0008526|phosphatidylinositol transporter activity;GO:0035091|phosphatidylinositol binding;",".","."]
["ENSRNOG00000010880",12,1.009623224,0,0.032165219,31.38866304,4.972171675,0.000127478,1.14011E-4,"up","yes","Gpr27","protein_coding","chr4:132328364-132329497:+","gi|12831217|ref|NP_075587.1|",1145,{"v":4e-152,"d":"4.00E-152"},"probable G-protein coupled receptor 27 [Rattus norvegicus]","gi|12831216|ref|NM_023099.1|",1128,0,"Rattus norvegicus G protein-coupled receptor 27 (Gpr27), mRNA","Q9JJH3",445,{"v":1E-153,"d":"1.00E-153"},"Probable G-protein coupled receptor 27",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0035774|positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:1900738|positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;","K04301","SREB1, GPR27; super conserved receptor expressed in brain 1"]
["ENSRNOG00000020276",12,1.009623224,0,0.032165219,31.38866304,4.972171675,0.000127478,1.14011E-4,"up","yes","Tnni2","protein_coding","chr1:197594813-197597560:+","gi|355566185|gb|EHH22564.1|",872,{"v":7e-113,"d":"7.00E-113"},"Troponin I, fast-twitch isoform, partial [Macaca mulatta]","gi|298889559|emb|FQ217454.1|",635,0,"Rattus norvegicus TL0ACA25YO07 mRNA sequence","P27768",335,{"v":3e-112,"d":"3.00E-112"},"Troponin I, fast skeletal muscle",".",".",".",".","pfam00992","Troponin","Troponin. Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). this Pfam contains members of the TnT subunit. Troponin is a complex of three proteins, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). The troponin complex regulates Ca++ induced muscle contraction. This family includes troponin T and troponin I. Troponin I binds to actin and troponin T binds to tropomyosin.","GO:0003009|skeletal muscle contraction;GO:0006936|muscle contraction;GO:0006937|regulation of muscle contraction;GO:0045893|positive regulation of transcription, DNA-templated;GO:0060048|cardiac muscle contraction;","GO:0005634|nucleus;GO:0005861|troponin complex;","GO:0003674|molecular_function;GO:0003779|actin binding;GO:0031014|troponin T binding;","K12043","TNNI2; troponin I, fast skeletal muscle"]
["ENSRNOG00000063968",12,1.009623224,0,0.032165219,31.38866304,4.972171675,0.000127478,1.14011E-4,"up","yes","Olr302","protein_coding","chr1:195387774-195399522:+","gi|149061495|gb|EDM11918.1|",1561,0,"rCG47792 [Rattus norvegicus]","gi|76362887|gb|AC116450.17|",1020,0,"Mus musculus chromosome 7, clone RP24-249O20, complete sequence","Q8NGR1",413,{"v":1e-128,"d":"1.00E-128"},"Olfactory receptor 13A1",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.",".",".",".",".","."]
["ENSRNOG00000064930",12,1.009623224,0,0.032165219,31.38866304,4.972171675,0.000127478,1.14011E-4,"up","yes","ENSRNOG00000064930","protein_coding","chr4:99208826-99241492:+","gi|149037314|gb|EDL91789.1|",446,{"v":3e-54,"d":"3.00E-54"},"rCG63213, partial [Rattus norvegicus]","gi|204830|gb|L07408.1|RATIGKVCL",271,{"v":3e-138,"d":"3.00E-138"},"Rattus norvegicus (hybridoma 56R-3) immunoglobulin rearranged kappa-chain mRNA variable (V) region, partial cds","P01635",150,{"v":2E-45,"d":"2.00E-45"},"Ig kappa chain V-V region K2 (Fragment)",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000066525",12,1.009623224,0,0.032165219,31.38866304,4.972171675,0.000127478,1.14011E-4,"up","yes","ENSRNOG00000066525","lncRNA","chr3:58486036-58501315:-","gi|26349815|dbj|BAC38547.1|",327,{"v":3e-29,"d":"3.00E-29"},"unnamed protein product [Mus musculus]","gi|672046007|ref|XM_008761960.1|",563,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102552170 (LOC102552170), transcript variant X3, mRNA","P31791",58.9,{"v":2e-07,"d":"2.00E-07"},"Envelope glycoprotein",".",".",".",".","pfam00429","TLV_coat","ENV polyprotein (coat polyprotein).",".",".",".",".","."]
["ENSRNOG00000018953",19,1.598570104,4,0.257321753,6.21233956,2.635136688,0.000127832,0.00011429,"up","yes","Cblc","protein_coding","chr1:79439977-79456755:-","gi|576011138|sp|G3V8H4.1|CBLC_RAT",2535,0,"RecName: Full=E3 ubiquitin-protein ligase CBL-C","gi|240255493|ref|NM_001034920.2|",1651,0,"Rattus norvegicus Cbl proto-oncogene C, E3 ubiquitin protein ligase (Cblc), mRNA","G3V8H4",959,0,"E3 ubiquitin-protein ligase CBL-C",".",".",".",".","pfam02762","Cbl_N3","CBL proto-oncogene N-terminus, SH2-like domain. Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. The so called N-terminal domain is actually 3 structural domains, of which this is the C-terminal SH2 domain.","GO:0006511|ubiquitin-dependent protein catabolic process;GO:0007165|signal transduction;GO:0007166|cell surface receptor signaling pathway;GO:0007175|negative regulation of epidermal growth factor-activated receptor activity;GO:0016567|protein ubiquitination;GO:0042059|negative regulation of epidermal growth factor receptor signaling pathway;GO:0043407|negative regulation of MAP kinase activity;","GO:0005886|plasma membrane;GO:0045121|membrane raft;","GO:0001784|phosphotyrosine residue binding;GO:0005154|epidermal growth factor receptor binding;GO:0005509|calcium ion binding;GO:0017124|SH3 domain binding;GO:0030971|receptor tyrosine kinase binding;GO:0061630|ubiquitin protein ligase activity;","K22518","CBLC; E3 ubiquitin-protein ligase CBL-C [EC:2.3.2.27]"]
["ENSRNOG00000036641",19,1.598570104,4,0.257321753,6.21233956,2.635136688,0.000127832,0.00011429,"up","yes","ENSRNOG00000036641","protein_coding","chr1:201784009-201785916:-","gi|157817095|ref|NP_001102991.1|",621,{"v":1e-76,"d":"1.00E-76"},"uncharacterized protein C11orf86 homolog [Rattus norvegicus]","gi|672039511|ref|XM_006230905.2|",1212,0,"PREDICTED: Rattus norvegicus hypothetical protein LOC689065 (LOC689065), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam15464","DUF4633","Domain of unknown function (DUF4633). This family of proteins is found in eukaryotes. Proteins in this family are typically between 94 and 123 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000007200",13,1.093758492,1,0.064330438,17.00219248,4.087648893,0.000132711,1.18361E-4,"up","yes","Ikzf3","protein_coding","chr10:83465745-83553591:-","gi|157820409|ref|NP_001100517.1|",2744,0,"zinc finger protein Aiolos [Rattus norvegicus]","gi|157820408|ref|NM_001107047.1|",2333,0,"Rattus norvegicus IKAROS family zinc finger 3 (Ikzf3), mRNA","O08900",1013,0,"Zinc finger protein Aiolos",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0009617|response to bacterium;GO:0030888|regulation of B cell proliferation;GO:0042981|regulation of apoptotic process;GO:0045577|regulation of B cell differentiation;GO:0045619|regulation of lymphocyte differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0042826|histone deacetylase binding;GO:0043565|sequence-specific DNA binding;GO:1990841|promoter-specific chromatin binding;","K09220","IKZF, ZNFN1A; IKAROS family zinc finger protein"]
["ENSRNOG00000026989",13,1.093758492,1,0.064330438,17.00219248,4.087648893,0.000132711,1.18361E-4,"up","yes","Gapt","protein_coding","chr2:41927532-41932093:-","gi|157823571|ref|NP_001102961.1|",712,{"v":9e-87,"d":"9.00E-87"},"protein GAPT [Rattus norvegicus]","gi|672041425|ref|XM_006231916.2|",1953,0,"PREDICTED: Rattus norvegicus Grb2-binding adaptor protein, transmembrane (Gapt), transcript variant X1, mRNA","Q8CB93",208,{"v":1E-61,"d":"1.00E-61"},"Protein GAPT",".",".",".",".","pfam11770","GAPT","GRB2-binding adapter (GAPT). This is a family of transmembrane proteins which bind the growth factor receptor-bound protein 2 (GRB2) in B cells. In contrast to other transmembrane adaptor proteins, GAPT is not phosphorylated upon BCR ligation. It associates with GRB2 constitutively through its proline-rich region.","GO:0001782|B cell homeostasis;GO:0002322|B cell proliferation involved in immune response;GO:0002381|immunoglobulin production involved in immunoglobulin mediated immune response;","GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;",".",".","."]
["ENSRNOG00000046972",13,1.093758492,1,0.064330438,17.00219248,4.087648893,0.000132711,1.18361E-4,"up","yes","Chrm2","protein_coding","chr4:65014144-65149103:+","gi|955517953|ref|XP_014643207.1|",2217,0,"PREDICTED: muscarinic acetylcholine receptor M2 [Ceratotherium simum simum]","gi|755516773|ref|XM_006506136.2|",3401,0,"PREDICTED: Mus musculus cholinergic receptor, muscarinic 2, cardiac (Chrm2), transcript variant X1, mRNA","P10980",847,0,"Muscarinic acetylcholine receptor M2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0006940|regulation of smooth muscle contraction;GO:0007187|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007197|adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway;GO:0007213|G protein-coupled acetylcholine receptor signaling pathway;GO:0007268|chemical synaptic transmission;GO:0008016|regulation of heart contraction;GO:0009615|response to virus;GO:0098664|G protein-coupled serotonin receptor signaling pathway;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0032279|asymmetric synapse;GO:0032280|symmetric synapse;GO:0043025|neuronal cell body;GO:0043679|axon terminus;GO:0045202|synapse;GO:0098978|glutamatergic synapse;GO:0098981|cholinergic synapse;GO:0099055|integral component of postsynaptic membrane;GO:0099056|integral component of presynaptic membrane;","GO:0004993|G protein-coupled serotonin receptor activity;GO:0016907|G protein-coupled acetylcholine receptor activity;GO:0030594|neurotransmitter receptor activity;GO:1990763|arrestin family protein binding;","K04130","CHRM2; muscarinic acetylcholine receptor M2"]
["ENSRNOG00000058068",57,4.795710313,33,2.12290446,2.259032567,1.17570507,0.000137831,1.22645E-4,"up","yes","Obscn","protein_coding","chr10:43789293-43919723:-","gi|913493414|ref|XP_013202511.1|",28304,0,"PREDICTED: obscurin [Microtus ochrogaster]","gi|672025632|ref|XM_008775745.1|",8375,0,"PREDICTED: Rattus norvegicus obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF (Obscn), transcript variant X1, mRNA","A2AAJ9",8135,0,"Obscurin",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0006468|protein phosphorylation;GO:0014067|negative regulation of phosphatidylinositol 3-kinase signaling;GO:0046777|protein autophosphorylation;GO:0050790|regulation of catalytic activity;","GO:0005615|extracellular space;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0014704|intercalated disc;GO:0016604|nuclear body;GO:0030017|sarcomere;GO:0030018|Z disc;GO:0031430|M band;GO:0042383|sarcolemma;","GO:0004672|protein kinase activity;GO:0005085|guanyl-nucleotide exchange factor activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;GO:0010314|phosphatidylinositol-5-phosphate binding;GO:0030506|ankyrin binding;GO:0031432|titin binding;GO:0032266|phosphatidylinositol-3-phosphate binding;GO:0043325|phosphatidylinositol-3,4-bisphosphate binding;GO:0045296|cadherin binding;GO:0046872|metal ion binding;GO:0070273|phosphatidylinositol-4-phosphate binding;GO:1902936|phosphatidylinositol bisphosphate binding;","K17531","OBSCN, ARHGEF30; obscurin-RhoGEF [EC:2.7.11.1]"]
["ENSRNOG00000025640",17,1.430299567,3,0.192991315,7.411212107,2.889709515,0.00014356,0.000127452,"up","yes","ENSRNOG00000025640","protein_coding","chr15:24291243-24295559:-","gi|564385934|ref|XP_006251931.1|",1843,0,"PREDICTED: olfactory receptor Olr1637 isoform X1 [Rattus norvegicus]","gi|672077519|ref|XM_006251869.2|",1348,0,"PREDICTED: Rattus norvegicus olfactory receptor 1637 (Olr1637), transcript variant X1, mRNA","Q8NH40",556,0,"Olfactory receptor 6S1",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0050911|detection of chemical stimulus involved in sensory perception of smell;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004984|olfactory receptor activity;","K04257","OLFR; olfactory receptor"]
["ENSRNOG00000042289",17,1.430299567,3,0.192991315,7.411212107,2.889709515,0.00014356,0.000127452,"up","yes","Plcxd2","protein_coding","chr11:54789477-54853344:+","gi|197333713|ref|NP_001127953.1|",1832,0,"PI-PLC X domain-containing protein 2 [Rattus norvegicus]","gi|197333712|ref|NM_001134481.1|",7359,0,"Rattus norvegicus phosphatidylinositol-specific phospholipase C, X domain containing 2 (Plcxd2), mRNA","B2RXA1",702,0,"PI-PLC X domain-containing protein 2",".",".",".",".","pfam00388","PI-PLC-X","Phosphatidylinositol-specific phospholipase C, X domain. This associates with pfam00387 to form a single structural unit.","GO:0006629|lipid metabolic process;",".","GO:0008081|phosphoric diester hydrolase activity;",".","."]
["ENSRNOG00000046258",17,1.430299567,3,0.192991315,7.411212107,2.889709515,0.00014356,0.000127452,"up","yes","B3gnt5","protein_coding","chr11:81140599-81156166:-","gi|281306748|ref|NP_446384.1|",2048,0,"lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase [Rattus norvegicus]","gi|672071646|ref|XM_008768849.1|",3852,0,"PREDICTED: Rattus norvegicus UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 (B3gnt5), transcript variant X1, mRNA","Q99NB2",793,0,"Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase",".",".",".",".","pfam01762","Galactosyl_T","Galactosyltransferase. This family includes the galactosyltransferases UDP-galactose:2-acetamido-2-deoxy-D-glucose3beta-galactosyltransferase and UDP-Gal:beta-GlcNAc beta 1,3-galactosyltranferase. Specific galactosyltransferases transfer galactose to GlcNAc terminal chains in the synthesis of the lacto-series oligosaccharides types 1 and 2.","GO:0006486|protein glycosylation;GO:0007417|central nervous system development;GO:0007420|brain development;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0008457|beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity;GO:0016757|transferase activity, transferring glycosyl groups;GO:0047256|lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity;","K03766","B3GNT5; beta-1,3-N-acetylglucosaminyltransferase 5 [EC:2.4.1.206]"]
["ENSRNOG00000067207",58,4.879845581,34,2.187234898,2.231056932,1.157727329,0.00014567,0.000129156,"up","yes","ENSRNOG00000067207","lncRNA","chr7:122821943-122826368:-","gi|149017598|gb|EDL76602.1|",238,{"v":2e-20,"d":"2.00E-20"},"rCG59223 [Rattus norvegicus]","gi|49170118|gb|AC112081.8|",3722,0,"Rattus norvegicus 7 BAC CH230-192B8 (Children's Hospital Oakland Research Institute) complete sequence","P11369",60.5,{"v":1e-07,"d":"1.00E-07"},"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam13687","DUF4153","Domain of unknown function (DUF4153). Members of this family are annotated as putative inner membrane proteins.",".",".",".",".","."]
["ENSRNOG00000008765",15,1.26202903,2,0.128660876,9.808957201,3.29409977,0.000147304,0.000130521,"up","yes","Zfhx4","protein_coding","chr2:96224767-96408228:-","gi|564335900|ref|XP_006232224.1|",16178,0,"PREDICTED: zinc finger homeobox protein 4 isoform X1 [Rattus norvegicus]","gi|672041888|ref|XM_006232162.2|",13988,0,"PREDICTED: Rattus norvegicus zinc finger homeobox 4 (Zfhx4), transcript variant X1, mRNA","Q9JJN2",5783,0,"Zinc finger homeobox protein 4","ECU06g0500",51.6,{"v":5e-06,"d":"5.00E-06"},"COG5576","pfam00046","Homeobox","Homeobox domain.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0008270|zinc ion binding;","K09380","ZFHX4; zinc finger homeobox protein 4"]
["ENSRNOG00000067752",35,2.944734403,15,0.964956573,3.051675574,1.609601596,0.000148652,1.31607E-4,"up","yes","ENSRNOG00000067752","protein_coding","chr3:163849743-163920329:-","gi|148674744|gb|EDL06691.1|",295,{"v":5e-29,"d":"5.00E-29"},"mCG126332, partial [Mus musculus]","gi|672017837|ref|XM_008775631.1|",208,{"v":3E-103,"d":"3.00E-103"},"PREDICTED: Rattus norvegicus zinc finger protein 658-like (LOC102549189), transcript variant X1, mRNA","Q8BZW4",92.4,{"v":5e-21,"d":"5.00E-21"},"Zinc finger protein 120",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.",".",".",".",".","."]
["ENSRNOG00000027319",22,1.85097591,6,0.385982629,4.795490187,2.261678293,1.60469E-4,0.00014122,"up","yes","Ephx3","protein_coding","chr7:11206812-11212122:-","gi|157823285|ref|NP_001102458.1|",1881,0,"epoxide hydrolase 3 [Rattus norvegicus]","gi|157823284|ref|NM_001108988.1|",1607,0,"Rattus norvegicus epoxide hydrolase 3 (Ephx3), mRNA","Q3V1F8",554,0,"Epoxide hydrolase 3",".",".",".",".","pfam12697","Abhydrolase_6","Alpha/beta hydrolase family. This family contains alpha/beta hydrolase enzymes of diverse specificity.","GO:0008150|biological_process;GO:0097176|epoxide metabolic process;","GO:0005575|cellular_component;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0003674|molecular_function;GO:0004301|epoxide hydrolase activity;GO:0016787|hydrolase activity;","K22368","EPHX3; epoxide hydrolase 3 [EC:3.3.2.10]"]
["ENSRNOG00000028072",61,5.132251387,37,2.380226213,2.156203204,1.108493147,0.000168807,0.000148175,"up","yes","Chit1","protein_coding","chr13:45593845-45613592:+","gi|119120779|ref|NP_001073157.1|",2417,0,"chitotriosidase-1 precursor [Rattus norvegicus]","gi|399220365|ref|NM_001079689.2|",2186,0,"Rattus norvegicus chitinase 1 (Chit1), transcript variant bChiV_5, mRNA","Q9D7Q1",773,0,"Chitotriosidase-1","BH0916_1",188,{"v":3E-51,"d":"3.00E-51"},"COG3325","pfam00704","Glyco_hydro_18","Glycosyl hydrolases family 18.","GO:0005975|carbohydrate metabolic process;GO:0006032|chitin catabolic process;","GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0004568|chitinase activity;GO:0008061|chitin binding;GO:0008843|endochitinase activity;","K01183","E3.2.1.14; chitinase [EC:3.2.1.14]"]
["ENSRNOG00000002305",32,2.692328597,13,0.836295696,3.219350056,1.686769457,1.76482E-4,0.000154576,"up","yes","Slc15a2","protein_coding","chr11:64014182-64043225:+","gi|404312669|ref|NP_113860.2|",3578,0,"solute carrier family 15 member 2 [Rattus norvegicus]","gi|404312668|ref|NM_031672.2|",3881,0,"Rattus norvegicus solute carrier family 15 member 2 (Slc15a2), mRNA","Q63424",1358,0,"Solute carrier family 15 member 2","ECU11g1050",178,{"v":2E-46,"d":"2.00E-46"},"COG3104","pfam00854","PTR2","POT family. The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.","GO:0006857|oligopeptide transport;GO:0015031|protein transport;GO:0015835|peptidoglycan transport;GO:0042908|xenobiotic transport;GO:0042938|dipeptide transport;GO:0045087|innate immune response;GO:0070293|renal absorption;GO:0070424|regulation of nucleotide-binding oligomerization domain containing signaling pathway;GO:0140206|dipeptide import across plasma membrane;GO:1902600|proton transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;","GO:0015333|peptide:proton symporter activity;GO:0015334|high-affinity oligopeptide transmembrane transporter activity;GO:0071916|dipeptide transmembrane transporter activity;","K14637","SLC15A2, PEPT2; solute carrier family 15 (oligopeptide transporter), member 2"]
["ENSRNOG00000016203",41,3.449546015,20,1.286608764,2.681114968,1.422833084,0.000177833,0.000155671,"up","yes","Efna2","protein_coding","chr7:9516429-9527061:-","gi|247269362|ref|NP_031935.3|",1043,{"v":4e-139,"d":"4.00E-139"},"ephrin-A2 precursor [Mus musculus]","gi|274327666|ref|NM_001168670.1|",1177,0,"Rattus norvegicus ephrin A2 (Efna2), mRNA","P52801",406,{"v":1e-140,"d":"1.00E-140"},"Ephrin-A2",".",".",".",".","pfam00812","Ephrin","Ephrin.","GO:0007411|axon guidance;GO:0021772|olfactory bulb development;GO:0030316|osteoclast differentiation;GO:0042472|inner ear morphogenesis;GO:0046849|bone remodeling;GO:0048013|ephrin receptor signaling pathway;","GO:0005886|plasma membrane;GO:0031225|anchored component of membrane;GO:0031594|neuromuscular junction;GO:0043204|perikaryon;","GO:0046875|ephrin receptor binding;","K05462","EFNA; ephrin-A"]
["ENSRNOG00000054339",41,3.449546015,20,1.286608764,2.681114968,1.422833084,0.000177833,0.000155671,"up","yes","SNORA70","snoRNA","chrX:152056109-152056244:+",".",".",".",".","gi|50872172|gb|AC094668.10|",136,{"v":8e-64,"d":"8.00E-64"},"Rattus norvegicus BAC CH230-5F18 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam03055","RPE65","Retinal pigment epithelial membrane protein. This family represents a retinal pigment epithelial membrane receptor which is abundantly expressed in retinal pigment epithelium, and binds plasma retinal binding protein. The family also includes the sequence related neoxanthin cleavage enzyme in plants and lignostilbene-alpha,beta-dioxygenase in bacteria.",".",".",".",".","."]
["ENSRNOG00000038328",54,4.543304507,31,1.994243584,2.278209414,1.187900367,0.000183342,1.60235E-4,"up","yes","Gjc2","protein_coding","chr10:43962642-43970467:-","gi|564372327|ref|XP_006246574.1|",1267,{"v":3e-164,"d":"3.00E-164"},"PREDICTED: gap junction gamma-2 protein isoform X3 [Rattus norvegicus]","gi|294832036|ref|NM_001100784.1|",2081,0,"Rattus norvegicus gap junction protein, gamma 2 (Gjc2), mRNA","Q80XF7",478,{"v":6e-161,"d":"6.00E-161"},"Gap junction gamma-2 protein",".",".",".",".","pfam00029","Connexin","Connexin.","GO:0001932|regulation of protein phosphorylation;GO:0007267|cell-cell signaling;GO:0007420|brain development;GO:0009636|response to toxic substance;GO:0010628|positive regulation of gene expression;GO:0010644|cell communication by electrical coupling;GO:0055085|transmembrane transport;GO:0070447|positive regulation of oligodendrocyte progenitor proliferation;GO:1904427|positive regulation of calcium ion transmembrane transport;GO:2000134|negative regulation of G1/S transition of mitotic cell cycle;","GO:0005921|gap junction;GO:0005922|connexin complex;GO:0016021|integral component of membrane;GO:0033270|paranode region of axon;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0043209|myelin sheath;GO:1990769|proximal neuron projection;","GO:0003674|molecular_function;GO:0005243|gap junction channel activity;GO:1903763|gap junction channel activity involved in cell communication by electrical coupling;","K07619","GJC2, GJA12, CX47; gap junction gamma-2 protein"]
["ENSRNOG00000063899",54,4.543304507,31,1.994243584,2.278209414,1.187900367,0.000183342,1.60235E-4,"up","yes","ENSRNOG00000063899","lncRNA","chrX:151395436-151396485:+",".",".",".",".","gi|49615138|gb|AC096338.17|",1050,0,"Rattus norvegicus X BAC CH230-95I19 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam07592","DDE_Tnp_ISAZ013","Rhodopirellula transposase DDE domain. These transposases are found in the planctomycete Rhodopirellula baltica, the cyanobacterium Nostoc, and the Gram-positive bacterium Streptomyces.",".",".",".",".","."]
["ENSRNOG00000010497",63,5.300521925,39,2.508887089,2.112698474,1.079086879,1.83726E-4,1.60545E-4,"up","yes","RGD1305807","protein_coding","chr5:60107085-60147539:+","gi|70608181|ref|NP_001020447.1|",2983,0,"uncharacterized protein LOC298077 [Rattus norvegicus]","gi|70608180|ref|NM_001025276.1|",2424,0,"Rattus norvegicus hypothetical LOC298077 (RGD1305807), mRNA","Q9DBN1",1070,0,"Stimulated by retinoic acid gene 6 protein-like",".",".",".",".","pfam14752","RBP_receptor","Retinol binding protein receptor. Proteins in this family function as retinol binding protein receptors.","GO:0034633|retinol transport;GO:0071939|vitamin A import;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;",".","K23088","STRA6; vitamin A receptor/transporter (stra6) family protein"]
["ENSRNOG00000049734",65,5.468792462,41,2.637547966,2.073438107,1.052024983,1.9809E-4,0.00017235,"up","yes","Slc5a4","protein_coding","chr20:12475644-12518738:-","gi|157823978|ref|NP_001099853.1|",2751,0,"low affinity sodium-glucose cotransporter [Rattus norvegicus]","gi|157823977|ref|NM_001106383.1|",2079,0,"Rattus norvegicus solute carrier family 5 (glucose activated ion channel), member 4 (Slc5a4), mRNA","Q9ET37",951,0,"Solute carrier family 5 member 4A","BH2222",153,{"v":8e-39,"d":"8.00E-39"},"COG4146","pfam00474","SSF","Sodium:solute symporter family. Membership of this family is supported by a significant blast score.","GO:0006814|sodium ion transport;GO:1902600|proton transmembrane transport;GO:1904659|glucose transmembrane transport;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0005412|glucose:sodium symporter activity;GO:0015078|proton transmembrane transporter activity;","K14384","SLC5A4, SGLT3; solute carrier family 5 (low affinity sodium-glucose cotransporter), member 4"]
["ENSRNOG00000067464",20,1.682705373,5,0.321652191,5.23144384,2.387209175,0.00020189,1.75544E-4,"up","yes","Cysltr2","protein_coding","chr15:48189073-48304136:-","gi|19173778|ref|NP_596904.1|",1633,0,"cysteinyl leukotriene receptor 2 [Rattus norvegicus]","gi|672078647|ref|XM_008770842.1|",3512,0,"PREDICTED: Rattus norvegicus cysteinyl leukotriene receptor 2 (Cysltr2), transcript variant X1, mRNA","Q924T9",633,0,"Cysteinyl leukotriene receptor 2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.",".",".",".",".","."]
["ENSRNOG00000068207",29,2.439922791,11,0.70763482,3.447997077,1.785758551,2.02711E-4,1.76174E-4,"up","yes","ENSRNOG00000068207","lncRNA","chr2:60865483-60868273:-",".",".",".",".","gi|672041529|ref|XM_006232045.2|",2787,0,"PREDICTED: Rattus norvegicus natriuretic peptide receptor 3 (Npr3), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam00965","TIMP","Tissue inhibitor of metalloproteinase. Members of this family are common in extracellular regions of vertebrate species",".",".",".",".","."]
["ENSRNOG00000009427",33,2.776463865,14,0.900626135,3.08281512,1.624248372,0.000209372,1.81876E-4,"up","yes","Tbx21","protein_coding","chr10:82082322-82098831:-","gi|157824180|ref|NP_001100513.1|",2493,0,"T-box transcription factor TBX21 [Rattus norvegicus]","gi|157824179|ref|NM_001107043.1|",2428,0,"Rattus norvegicus T-box 21 (Tbx21), mRNA","Q9JKD8",909,0,"T-box transcription factor TBX21",".",".",".",".","pfam00907","T-box","T-box. The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001708|cell fate specification;GO:0006357|regulation of transcription by RNA polymerase II;GO:0009615|response to virus;GO:0010628|positive regulation of gene expression;GO:0030217|T cell differentiation;GO:0032703|negative regulation of interleukin-2 production;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045580|regulation of T cell differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0048304|positive regulation of isotype switching to IgG isotypes;GO:0050776|regulation of immune response;GO:0071310|cellular response to organic substance;GO:0072676|lymphocyte migration;GO:2000320|negative regulation of T-helper 17 cell differentiation;GO:2000329|negative regulation of T-helper 17 cell lineage commitment;GO:2000552|negative regulation of T-helper 2 cell cytokine production;","GO:0005634|nucleus;GO:0043025|neuronal cell body;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K10166","TBX21; T-box protein 21"]
["ENSRNOG00000012049",67,5.637062999,43,2.766208842,2.037829868,1.02703361,0.000211797,0.000183865,"up","yes","Sox7","protein_coding","chr15:38180503-38187264:+","gi|157823179|ref|NP_001099515.1|",1870,0,"transcription factor SOX-7 [Rattus norvegicus]","gi|157823178|ref|NM_001106045.1|",3282,0,"Rattus norvegicus SRY box 7 (Sox7), mRNA","P40646",708,0,"Transcription factor SOX-7",".",".",".",".","pfam12067","Sox_C_TAD","Sox C-terminal transactivation domain. This domain is found at the C-terminus of the Sox family of transcription factors. It is found associated with pfam00505. It binds to the Armadillo repeats (pfam00514) in Catenin beta-1 (CTNNB1), which is involved in transcriptional regulation. It functions as a transactivating domain (TAD).","GO:0001706|endoderm formation;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008150|biological_process;GO:0008285|negative regulation of cell proliferation;GO:0009653|anatomical structure morphogenesis;GO:0030154|cell differentiation;GO:0043280|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0060828|regulation of canonical Wnt signaling pathway;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005737|cytoplasm;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003700|DNA-binding transcription factor activity;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09270","SOX7S; transcription factor SOX7/8/10/18 (SOX group E/F)"]
["ENSRNOG00000007354",49,4.122628164,27,1.736921831,2.373525446,1.247031517,0.00021325,0.000185097,"up","yes","Trpa1","protein_coding","chr5:4379999-4433570:+","gi|46485385|ref|NP_997491.1|",6015,0,"transient receptor potential cation channel subfamily A member 1 [Rattus norvegicus]","gi|46485384|ref|NM_207608.1|",3369,0,"Rattus norvegicus transient receptor potential cation channel, subfamily A, member 1 (Trpa1), mRNA","Q6RI86",2321,0,"Transient receptor potential cation channel subfamily A member 1","all2748",123,{"v":2e-28,"d":"2.00E-28"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0006816|calcium ion transport;GO:0006874|cellular calcium ion homeostasis;GO:0007166|cell surface receptor signaling pathway;GO:0009409|response to cold;GO:0009410|response to xenobiotic stimulus;GO:0010033|response to organic substance;GO:0014070|response to organic cyclic compound;GO:0014832|urinary bladder smooth muscle contraction;GO:0019233|sensory perception of pain;GO:0034605|cellular response to heat;GO:0035774|positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0042542|response to hydrogen peroxide;GO:0048265|response to pain;GO:0050955|thermoception;GO:0050966|detection of mechanical stimulus involved in sensory perception of pain;GO:0050968|detection of chemical stimulus involved in sensory perception of pain;GO:0051209|release of sequestered calcium ion into cytosol;GO:0051289|protein homotetramerization;GO:0070417|cellular response to cold;GO:0070588|calcium ion transmembrane transport;GO:0071244|cellular response to carbon dioxide;GO:0071310|cellular response to organic substance;GO:0071313|cellular response to caffeine;GO:0097553|calcium ion transmembrane import into cytosol;GO:0098908|regulation of neuronal action potential;GO:1903522|regulation of blood circulation;GO:1903793|positive regulation of anion transport;GO:1904058|positive regulation of sensory perception of pain;","GO:0005887|integral component of plasma membrane;GO:0016324|apical plasma membrane;GO:0030424|axon;GO:0032421|stereocilium bundle;","GO:0005216|ion channel activity;GO:0005245|voltage-gated calcium channel activity;GO:0005262|calcium channel activity;GO:0005515|protein binding;GO:0015267|channel activity;GO:0015278|calcium-release channel activity;GO:0042802|identical protein binding;GO:0097604|temperature-gated cation channel activity;GO:1990760|osmolarity-sensing cation channel activity;","K04984","TRPA1, ANKTM1; transient receptor potential cation channel subfamily A member 1"]
["ENSRNOG00000008922",43,3.617816552,22,1.41526964,2.556273695,1.354042311,0.000218046,0.000188868,"up","yes","Trim14","protein_coding","chr5:60800032-60824858:-","gi|157817684|ref|NP_001101404.1|",1863,0,"tripartite motif-containing protein 14 [Rattus norvegicus]","gi|157817683|ref|NM_001107934.1|",3446,0,"Rattus norvegicus tripartite motif-containing 14 (Trim14), mRNA","Q8BVW3",598,0,"Tripartite motif-containing protein 14",".",".",".",".","pfam00622","SPRY","SPRY domain. SPRY Domain is named from SPla and the RYanodine Receptor. Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.","GO:0000209|protein polyubiquitination;GO:0008150|biological_process;GO:0010468|regulation of gene expression;GO:0010508|positive regulation of autophagy;GO:0016567|protein ubiquitination;GO:0032880|regulation of protein localization;GO:0032897|negative regulation of viral transcription;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045087|innate immune response;GO:0045893|positive regulation of transcription, DNA-templated;GO:0046596|regulation of viral entry into host cell;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051092|positive regulation of NF-kappaB transcription factor activity;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0003674|molecular_function;GO:0003713|transcription coactivator activity;GO:0008270|zinc ion binding;GO:0019901|protein kinase binding;GO:0042803|protein homodimerization activity;GO:0061630|ubiquitin protein ligase activity;","K12004","TRIM14; tripartite motif-containing protein 14"]
["ENSRNOG00000042070",68,5.721198268,44,2.83053928,2.021239666,1.015240397,0.000218377,0.000189095,"up","yes","Ticam2","protein_coding","chr18:39294453-39311462:-","gi|157820689|ref|NP_001102360.1|",1162,{"v":1e-147,"d":"1.00E-147"},"TIR domain-containing adapter molecule 2 [Rattus norvegicus]","gi|157820688|ref|NM_001108890.1|",3315,0,"Rattus norvegicus toll-like receptor adaptor molecule 2 (Ticam2), mRNA","Q8BJQ4",405,{"v":2E-131,"d":"2.00E-131"},"TIR domain-containing adapter molecule 2",".",".",".",".","pfam13676","TIR_2","TIR domain. This is a family of bacterial Toll-like receptors.","GO:0001817|regulation of cytokine production;GO:0006886|intracellular protein transport;GO:0006888|ER to Golgi vesicle-mediated transport;GO:0006909|phagocytosis;GO:0007030|Golgi organization;GO:0008150|biological_process;GO:0032729|positive regulation of interferon-gamma production;GO:0032755|positive regulation of interleukin-6 production;GO:0034144|negative regulation of toll-like receptor 4 signaling pathway;GO:0034145|positive regulation of toll-like receptor 4 signaling pathway;GO:0035669|TRAM-dependent toll-like receptor 4 signaling pathway;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0051607|defense response to virus;GO:0070671|response to interleukin-12;GO:0071222|cellular response to lipopolysaccharide;GO:0071650|negative regulation of chemokine (C-C motif) ligand 5 production;GO:0071651|positive regulation of chemokine (C-C motif) ligand 5 production;GO:2000494|positive regulation of interleukin-18-mediated signaling pathway;","GO:0001891|phagocytic cup;GO:0005575|cellular_component;GO:0005768|endosome;GO:0005769|early endosome;GO:0005770|late endosome;GO:0005783|endoplasmic reticulum;GO:0005793|endoplasmic reticulum-Golgi intermediate compartment;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0030134|COPII-coated ER to Golgi transport vesicle;","GO:0003674|molecular_function;GO:0003953|NAD+ nucleosidase activity;GO:0005543|phospholipid binding;","K05409","TIRP, TRAM; TRIF-related adaptor molecule"]
["ENSRNOG00000026432",23,1.935111179,7,0.450313067,4.29725744,2.103416209,2.25264E-4,1.94687E-4,"up","yes","Syt7","protein_coding","chr1:207031592-207089026:+","gi|564332916|ref|XP_006231127.1|",3187,0,"PREDICTED: synaptotagmin-7 isoform X1 [Rattus norvegicus]","gi|12667441|gb|AF336852.1|AF336852",2187,0,"Rattus norvegicus synaptotagmin VIIT1 (SytVII) mRNA, complete cds, alternatively spliced","Q62747",628,0,"Synaptotagmin-7","YOR086c",64.7,{"v":9e-10,"d":"9.00E-10"},"COG5038","pfam00168","C2","C2 domain.","GO:0001778|plasma membrane repair;GO:0005513|detection of calcium ion;GO:0006909|phagocytosis;GO:0014059|regulation of dopamine secretion;GO:0016192|vesicle-mediated transport;GO:0017156|calcium ion regulated exocytosis;GO:0017158|regulation of calcium ion-dependent exocytosis;GO:0036465|synaptic vesicle recycling;GO:0045956|positive regulation of calcium ion-dependent exocytosis;GO:0046850|regulation of bone remodeling;GO:0048791|calcium ion-regulated exocytosis of neurotransmitter;GO:0050764|regulation of phagocytosis;GO:0050796|regulation of insulin secretion;GO:0070092|regulation of glucagon secretion;GO:0071277|cellular response to calcium ion;GO:0090119|vesicle-mediated cholesterol transport;GO:0090385|phagosome-lysosome fusion;GO:0099502|calcium-dependent activation of synaptic vesicle fusion;GO:1900242|regulation of synaptic vesicle endocytosis;GO:1990926|short-term synaptic potentiation;GO:1990927|calcium ion regulated lysosome exocytosis;","GO:0005764|lysosome;GO:0005765|lysosomal membrane;GO:0005777|peroxisome;GO:0005778|peroxisomal membrane;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0008021|synaptic vesicle;GO:0030425|dendrite;GO:0030670|phagocytic vesicle membrane;GO:0030672|synaptic vesicle membrane;GO:0031045|dense core granule;GO:0032009|early phagosome;GO:0042734|presynaptic membrane;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0043679|axon terminus;GO:0070382|exocytic vesicle;GO:0098686|hippocampal mossy fiber to CA3 synapse;GO:0098978|glutamatergic synapse;GO:0098982|GABA-ergic synapse;GO:0099056|integral component of presynaptic membrane;","GO:0000149|SNARE binding;GO:0001786|phosphatidylserine binding;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0005516|calmodulin binding;GO:0005544|calcium-dependent phospholipid binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0019905|syntaxin binding;GO:0030276|clathrin binding;","K19907","SYT7; synaptotagmin-7"]
["ENSRNOG00000068266",23,1.935111179,7,0.450313067,4.29725744,2.103416209,2.25264E-4,1.94687E-4,"up","yes","Nxpe5","protein_coding","chr12:17097523-17119761:-","gi|564315084|ref|XP_003752620.2|",2793,0,"PREDICTED: NXPE family member 3-like isoform X1 [Rattus norvegicus]","gi|672072433|ref|XM_006249028.2|",1912,0,"PREDICTED: Rattus norvegicus neurexophilin and PC-esterase domain family, member 4 (Nxpe4), transcript variant X3, mRNA","A2VDP6",322,{"v":1E-97,"d":"1.00E-97"},"NXPE family member 3",".",".",".",".","pfam06312","Neurexophilin","Neurexophilin. This family consists of mammalian neurexophilin proteins. Mammalian brains contain four different neurexophilin proteins. Neurexophilins form a family of related glycoproteins that are proteolytically processed after synthesis and bind to alpha-neurexins. The structure and characteristics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins.",".",".",".",".","."]
["ENSRNOG00000014387",34,2.860599134,15,0.964956573,2.964484843,1.56778142,0.000244383,2.09812E-4,"up","yes","Chac1","protein_coding","chr3:106342302-106345526:+","gi|958753309|ref|XP_014712856.1|",1130,{"v":4e-148,"d":"4.00E-148"},"PREDICTED: LOW QUALITY PROTEIN: glutathione-specific gamma-glutamylcyclotransferase 1 [Equus asinus]","gi|290746390|ref|NM_001173437.1|",1566,0,"Rattus norvegicus ChaC glutathione-specific gamma-glutamylcyclotransferase 1 (Chac1), mRNA","B3STU3",407,{"v":6e-139,"d":"6.00E-139"},"Glutathione-specific gamma-glutamylcyclotransferase 1","SPBC31F10.03",99.8,{"v":7e-23,"d":"7.00E-23"},"COG3703","pfam04752","ChaC","ChaC-like protein. The ChaC protein is thought to be associated with the putative ChaA Ca2+/H+ cation transport protein in Escherichia coli. Its function is not known. This family also includes homologues regions from several other bacterial and eukaryotic proteins.","GO:0006751|glutathione catabolic process;GO:0006986|response to unfolded protein;GO:0007219|Notch signaling pathway;GO:0010955|negative regulation of protein processing;GO:0022008|neurogenesis;GO:0045746|negative regulation of Notch signaling pathway;GO:0070059|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;","GO:0005737|cytoplasm;GO:0005802|trans-Golgi network;GO:0005829|cytosol;","GO:0003839|gamma-glutamylcyclotransferase activity;GO:0005112|Notch binding;GO:0061928|glutathione specific gamma-glutamylcyclotransferase activity;","K07232","CHAC, chaC; glutathione-specific gamma-glutamylcyclotransferase [EC:4.3.2.7]"]
["ENSRNOG00000063575",34,2.860599134,15,0.964956573,2.964484843,1.56778142,0.000244383,2.09812E-4,"up","yes","ENSRNOG00000063575","protein_coding","chr18:71243208-71245690:+","gi|12853880|dbj|BAB29875.1|",272,{"v":2e-24,"d":"2.00E-24"},"unnamed protein product [Mus musculus]","gi|244790128|ref|NR_027978.1|",336,{"v":1E-173,"d":"1.00E-173"},"Mus musculus RIKEN cDNA 4930465K10 gene (4930465K10Rik), long non-coding RNA",".",".",".",".",".",".",".",".","pfam06075","DUF936","Plant protein of unknown function (DUF936). This family consists of several hypothetical proteins from Arabidopsis thaliana and Oryza sativa. The function of this family is unknown.",".",".",".",".","."]
["ENSRNOG00000026952",18,1.514434836,4,0.257321753,5.88537432,2.557134176,0.000245123,0.000210381,"up","yes","Rgsl1","protein_coding","chr13:65915097-65968954:-","gi|568909041|ref|XP_006529637.1|",4962,0,"PREDICTED: regulator of G-protein signaling protein-like isoform X1 [Mus musculus]","gi|755494277|ref|XM_006529574.2|",2627,0,"PREDICTED: Mus musculus regulator of G-protein signaling like 1 (Rgsl1), transcript variant X1, mRNA","A5PLK6",1429,0,"Regulator of G-protein signaling protein-like",".",".",".",".","pfam00615","RGS","Regulator of G protein signaling domain. RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.",".",".",".",".","."]
["ENSRNOG00000008478",60,5.048116119,37,2.380226213,2.120855611,1.084646405,2.46825E-4,0.000211708,"up","yes","Mmp13","protein_coding","chr8:4497960-4508239:+","gi|213972541|ref|NP_598214.1|",2448,0,"collagenase 3 precursor [Rattus norvegicus]","gi|213972540|ref|NM_133530.1|",2602,0,"Rattus norvegicus matrix metallopeptidase 13 (Mmp13), mRNA","P23097",932,0,"Collagenase 3 (Fragment)",".",".",".",".","pfam00413","Peptidase_M10","Matrixin. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.","GO:0001503|ossification;GO:0001554|luteolysis;GO:0001649|osteoblast differentiation;GO:0001666|response to hypoxia;GO:0001958|endochondral ossification;GO:0003417|growth plate cartilage development;GO:0006508|proteolysis;GO:0007507|heart development;GO:0007567|parturition;GO:0009410|response to xenobiotic stimulus;GO:0009612|response to mechanical stimulus;GO:0009725|response to hormone;GO:0022617|extracellular matrix disassembly;GO:0030198|extracellular matrix organization;GO:0030282|bone mineralization;GO:0030574|collagen catabolic process;GO:0035116|embryonic hindlimb morphogenesis;GO:0043171|peptide catabolic process;GO:0043627|response to estrogen;GO:0044267|cellular protein metabolic process;GO:0044849|estrous cycle;GO:0051216|cartilage development;GO:0060349|bone morphogenesis;GO:0071498|cellular response to fluid shear stress;GO:1904244|positive regulation of pancreatic trypsinogen secretion;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005764|lysosome;GO:0005794|Golgi apparatus;GO:0031012|extracellular matrix;GO:0046581|intercellular canaliculus;","GO:0001968|fibronectin binding;GO:0004175|endopeptidase activity;GO:0004222|metalloendopeptidase activity;GO:0004252|serine-type endopeptidase activity;GO:0005509|calcium ion binding;GO:0005518|collagen binding;GO:0008233|peptidase activity;GO:0008270|zinc ion binding;GO:0048306|calcium-dependent protein binding;GO:0050750|low-density lipoprotein particle receptor binding;","K07994","MMP13; matrix metalloproteinase-13 (collagenase 3) [EC:3.4.24.-]"]
["ENSRNOG00000042352",60,5.048116119,37,2.380226213,2.120855611,1.084646405,2.46825E-4,0.000211708,"up","yes","Dnase1l2","protein_coding","chr10:13471479-13473763:-","gi|564312394|ref|XP_006220655.1|",1821,0,"PREDICTED: deoxyribonuclease-1-like 2 isoform X2 [Rattus norvegicus]","gi|564312393|ref|XM_006220593.1|",1485,0,"PREDICTED: Rattus norvegicus deoxyribonuclease I-like 2 (Dnase1l2), transcript variant X2, mRNA","Q9D1G0",530,0,"Deoxyribonuclease-1-like 2",".",".",".",".","pfam03372","Exo_endo_phos","Endonuclease/Exonuclease/phosphatase family. This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins EC:4.2.99.18, DNase I proteins EC:3.1.21.1, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56, Sphingomyelinase EC:3.1.4.12 and Nocturnin.","GO:0000737|DNA catabolic process, endonucleolytic;GO:0001942|hair follicle development;GO:0003335|corneocyte development;GO:0006308|DNA catabolic process;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0004530|deoxyribonuclease I activity;","K11995","DNASE1L; deoxyribonuclease-1-like protein [EC:3.1.21.-]"]
["ENSRNOG00000009487",39,3.281275477,19,1.222278326,2.684556708,1.42468388,0.000252611,0.000216433,"up","yes","Gpr160","protein_coding","chr2:112484935-112563148:-","gi|68341997|ref|NP_001020318.1|",1578,0,"probable G-protein coupled receptor 160 [Rattus norvegicus]","gi|672042140|ref|XM_008760935.1|",2513,0,"PREDICTED: Rattus norvegicus G protein-coupled receptor 160 (Gpr160), transcript variant X1, mRNA","Q66H29",612,0,"Probable G-protein coupled receptor 160",".",".",".",".","pfam06736","DUF1211","Protein of unknown function (DUF1211). This family represents a conserved region within a number of hypothetical proteins of unknown function found in eukaryotes, bacteria and archaea. These may possibly be integral membrane proteins.","GO:0007186|G protein-coupled receptor signaling pathway;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0043235|receptor complex;","GO:0004930|G protein-coupled receptor activity;","K08438","GPR160; G protein-coupled receptor 160"]
["ENSRNOG00000001943",11,0.925487955,0,0.032165219,28.77294112,4.846640793,0.000257993,0.000220661,"up","yes","Retnlg","protein_coding","chr11:51930936-51932830:-","gi|564376685|ref|XP_006248344.1|",578,{"v":1e-72,"d":"1.00E-72"},"PREDICTED: resistin-like beta isoform X1 [Rattus norvegicus]","gi|672070839|ref|XM_006248282.2|",581,0,"PREDICTED: Rattus norvegicus resistin-like gamma (Retnlg), transcript variant X1, mRNA","G3V686",227,{"v":4e-74,"d":"4.00E-74"},"Resistin-like gamma",".",".",".",".","pfam06954","Resistin","Resistin. This family consists of several mammalian resistin proteins. Resistin is a 12.5-kDa cysteine-rich secreted polypeptide first reported from rodent adipocytes. It belongs to a multigene family termed RELMs or FIZZ proteins. Plasma resistin levels are significantly increased in both genetically susceptible and high-fat-diet-induced obese mice. Immunoneutralization of resistin improves hyperglycemia and insulin resistance in high-fat-diet-induced obese mice, while administration of recombinant resistin impairs glucose tolerance and insulin action in normal mice. It has been demonstrated that increases in circulating resistin levels markedly stimulate glucose production in the presence of fixed physiological insulin levels, whereas insulin suppressed resistin expression. It has been suggested that resistin could be a link between obesity and type 2 diabetes.","GO:0007165|signal transduction;","GO:0005615|extracellular space;","GO:0005125|cytokine activity;GO:0005179|hormone activity;","K13438","RETN; resistin"]
["ENSRNOG00000021499",11,0.925487955,0,0.032165219,28.77294112,4.846640793,0.000257993,0.000220661,"up","yes","Siglech","protein_coding","chr1:106593721-106598022:+","gi|293344093|ref|XP_001054672.2|",1677,0,"PREDICTED: myeloid cell surface antigen CD33 isoform X1 [Rattus norvegicus]","gi|298908737|emb|FQ232259.1|",1011,0,"Rattus norvegicus TL0AEA66YH10 mRNA sequence","P20138",250,{"v":2E-78,"d":"2.00E-78"},"Myeloid cell surface antigen CD33",".",".",".",".","pfam08205","C2-set_2","CD80-like C2-set immunoglobulin domain. These domains belong to the immunoglobulin superfamily.","GO:0007155|cell adhesion;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0033691|sialic acid binding;","K06473","CD33, SIGLEC3; CD33 antigen"]
["ENSRNOG00000021357",45,3.786087089,24,1.543930516,2.4522393,1.29409977,0.000259752,0.000222061,"up","yes","AC118772.2","protein_coding","chr10:68055355-68060603:+","gi|672025020|ref|XP_008773388.1|",2578,0,"PREDICTED: schlafen family member 12-like [Rattus norvegicus]","gi|672068330|ref|XM_008767933.1|",1227,0,"PREDICTED: Rattus norvegicus schlafen 3 (Slfn3), transcript variant X1, mRNA","Q8IYM2",427,{"v":7e-141,"d":"7.00E-141"},"Schlafen family member 12",".",".",".",".","pfam04326","AAA_4","Divergent AAA domain. This family is related to the pfam00004 family, and presumably has the same function (ATP-binding).",".",".",".",".","."]
["ENSRNOG00000056815",12,1.009623224,1,0.064330438,15.69433152,3.972171675,2.72799E-4,0.000232485,"up","yes","AABR07032623.1","snoRNA","chr18:71213119-71213246:+",".",".",".",".","gi|908662265|tpe|LN871987.1|",63,{"v":3E-23,"d":"3.00E-23"},"TPA: Mus musculus SNORA17 (ACA17) gene for small nucleolar RNA SNORA17 (ACA17)",".",".",".",".",".",".",".",".","pfam08325","WLM","WLM domain. This is a predicted metallopeptidase domain called WLM (Wss1p-like metalloproteases). These are linked to the Ub-system by virtue of fusions with the UB-binding PUG (PUB), Ub-like, and Little Finger domains. More specifically, genetic evidence implicates the WLM family in de-SUMOylation.",".",".",".",".","."]
["ENSRNOG00000065045",12,1.009623224,1,0.064330438,15.69433152,3.972171675,2.72799E-4,0.000232485,"up","yes","ENSRNOG00000065045","lncRNA","chr16:66086170-66087986:-",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","pfam02627","CMD","Carboxymuconolactone decarboxylase family. Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.",".",".",".",".","."]
["ENSRNOG00000018101",27,2.271652253,10,0.643304382,3.531224592,1.820168582,0.000280624,2.38519E-4,"up","yes","Klc3","protein_coding","chr1:79045844-79055416:-","gi|564326478|ref|XP_006228440.1|",2196,0,"PREDICTED: kinesin light chain 3 isoform X3 [Rattus norvegicus]","gi|67678318|gb|BC097284.1|",1772,0,"Rattus norvegicus kinesin light chain 3, mRNA (cDNA clone MGC:114264 IMAGE:7454436), complete cds","Q68G30",846,0,"Kinesin light chain 3",".",".",".",".","pfam09311","Rab5-bind","Rabaptin-like protein. Members of this family are predominantly found in Rabaptin and allow for binding to the GTPase Rab5. This interaction is necessary and sufficient for Rab5-dependent recruitment of Rabaptin5 to early endosomal membranes.","GO:0008088|axo-dendritic transport;","GO:0005737|cytoplasm;GO:0005871|kinesin complex;GO:0005874|microtubule;GO:0031514|motile cilium;GO:0035253|ciliary rootlet;GO:0043005|neuron projection;","GO:0003777|microtubule motor activity;GO:0008017|microtubule binding;GO:0019894|kinesin binding;","K10407","KLC; kinesin light chain"]
["ENSRNOG00000014282",16,1.346164298,3,0.192991315,6.975258454,2.802246674,2.81864E-4,0.000239499,"up","yes","Cebpe","protein_coding","chr15:28169704-28171814:-","gi|74138080|dbj|BAE25437.1|",1465,0,"unnamed protein product [Mus musculus]","gi|625207221|ref|XM_003506128.2|",1107,0,"PREDICTED: Cricetulus griseus CCAAT/enhancer binding protein (C/EBP), epsilon (Cebpe), mRNA","P56261",512,{"v":3e-179,"d":"3.00E-179"},"CCAAT/enhancer-binding protein epsilon",".",".",".",".","pfam07716","bZIP_2","Basic region leucine zipper.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0006909|phagocytosis;GO:0010628|positive regulation of gene expression;GO:0030099|myeloid cell differentiation;GO:0030225|macrophage differentiation;GO:0030851|granulocyte differentiation;GO:0042742|defense response to bacterium;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0071222|cellular response to lipopolysaccharide;","GO:0005575|cellular_component;GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;GO:1990837|sequence-specific double-stranded DNA binding;","K10051","CEBPE; CCAAT/enhancer binding protein (C/EBP), epsilon"]
["ENSRNOG00000056001",16,1.346164298,3,0.192991315,6.975258454,2.802246674,2.81864E-4,0.000239499,"up","yes","Sftpd","protein_coding","chr16:17046483-17059927:-","gi|643358557|gb|AIA98493.1|",872,{"v":2e-110,"d":"2.00E-110"},"pulmonary surfactant protein D [Sigmodon hispidus]","gi|672079518|ref|XM_008771065.1|",1244,0,"PREDICTED: Rattus norvegicus surfactant protein D (Sftpd), transcript variant X1, mRNA","P35248",330,{"v":1E-107,"d":"1.00E-107"},"Pulmonary surfactant-associated protein D",".",".",".",".","pfam09006","Surfac_D-trimer","Lung surfactant protein D coiled-coil trimerization. This domain, predominantly found in lung surfactant protein D, forms a triple-helical parallel coiled coil, and mediates trimerization of the protein.","GO:0007585|respiratory gaseous exchange;GO:0008228|opsonization;GO:0031960|response to corticosteroid;GO:0032703|negative regulation of interleukin-2 production;GO:0042130|negative regulation of T cell proliferation;GO:0043129|surfactant homeostasis;GO:0043152|induction of bacterial agglutination;GO:0045087|innate immune response;GO:0048286|lung alveolus development;GO:0050765|negative regulation of phagocytosis;GO:0050766|positive regulation of phagocytosis;GO:0050828|regulation of liquid surface tension;GO:0051384|response to glucocorticoid;GO:0052403|negative regulation by host of symbiont catalytic activity;GO:0055093|response to hyperoxia;GO:0070848|response to growth factor;GO:1905226|regulation of adhesion of symbiont to host epithelial cell;","GO:0005581|collagen trimer;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005771|multivesicular body;GO:0005791|rough endoplasmic reticulum;GO:0031410|cytoplasmic vesicle;","GO:0001530|lipopolysaccharide binding;GO:0030246|carbohydrate binding;GO:0042802|identical protein binding;GO:0048029|monosaccharide binding;","K10068","SFTPD, SFTP4; pulmonary surfactant-associated protein D"]
["ENSRNOG00000062887",21,1.766840642,6,0.385982629,4.57751336,2.194564097,0.000294675,0.000249605,"up","yes","Gpr35","protein_coding","chr9:93527127-93539299:+","gi|564369848|ref|XP_006245599.1|",1513,0,"PREDICTED: G-protein coupled receptor 35 isoform X1 [Rattus norvegicus]","gi|672066184|ref|XM_006245537.2|",2936,0,"PREDICTED: Rattus norvegicus G protein-coupled receptor 35 (Gpr35), transcript variant X3, mRNA","Q9ES90",519,{"v":1E-172,"d":"1.00E-172"},"G-protein coupled receptor 35",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.",".",".",".",".","."]
["ENSRNOG00000016243",31,2.608193328,13,0.836295696,3.118745366,1.640965767,0.000294817,0.00024961,"up","yes","Casq2","protein_coding","chr2:189525960-189582267:+","gi|47940716|gb|AAH72547.1|",1987,0,"Calsequestrin 2 (cardiac muscle) [Rattus norvegicus]","gi|76563945|ref|NM_017131.2|",2416,0,"Rattus norvegicus calsequestrin 2 (Casq2), mRNA","O09161",721,0,"Calsequestrin-2",".",".",".",".","pfam01216","Calsequestrin","Calsequestrin.","GO:0002027|regulation of heart rate;GO:0008150|biological_process;GO:0010649|regulation of cell communication by electrical coupling;GO:0010880|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0010881|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;GO:0043267|negative regulation of potassium ion transport;GO:0045214|sarcomere organization;GO:0051208|sequestering of calcium ion;GO:0051258|protein polymerization;GO:0051279|regulation of release of sequestered calcium ion into cytosol;GO:0060048|cardiac muscle contraction;GO:0060306|regulation of membrane repolarization;GO:0060315|negative regulation of ryanodine-sensitive calcium-release channel activity;GO:0071313|cellular response to caffeine;GO:0086004|regulation of cardiac muscle cell contraction;GO:1901017|negative regulation of potassium ion transmembrane transporter activity;","GO:0005737|cytoplasm;GO:0016529|sarcoplasmic reticulum;GO:0030018|Z disc;GO:0030314|junctional membrane complex;GO:0033018|sarcoplasmic reticulum lumen;","GO:0005080|protein kinase C binding;GO:0005509|calcium ion binding;GO:0042803|protein homodimerization activity;GO:0048306|calcium-dependent protein binding;","K23445","CASQ2; calsequestrin 2"]
["ENSRNOG00000069239",31,2.608193328,13,0.836295696,3.118745366,1.640965767,0.000294817,0.00024961,"up","yes","ENSRNOG00000069239","protein_coding","chr10:38104122-38130671:-","gi|109490712|ref|XP_001073573.1|",1735,0,"PREDICTED: solute carrier family 22 member 21 [Rattus norvegicus]","gi|73254762|gb|DQ119106.1|",2862,0,"Rattus norvegicus mRNA stabilizer 2b1 splice variant mRNA, complete cds, alternatively spliced","Q9WTN6",599,0,"Solute carrier family 22 member 21",".",".",".",".","pfam00083","Sugar_tr","Sugar (and other) transporter.",".",".",".",".","."]
["ENSRNOG00000038215",14,1.177893761,2,0.128660876,9.155026721,3.194564097,0.00029696,0.000251345,"up","yes","AC120448.1","protein_coding","chr4:103294885-103295463:+","gi|672018419|ref|XP_008773990.1|",949,{"v":3e-128,"d":"3.00E-128"},"PREDICTED: zinc finger matrin-type protein 1-like [Rattus norvegicus]","gi|672018418|ref|XM_008775768.1|",579,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102552663 (LOC102552663), mRNA","Q5H9K5",60.8,{"v":1e-09,"d":"1.00E-09"},"Zinc finger matrin-type protein 1",".",".",".",".","pfam06632","XRCC4","DNA double-strand break repair and V(D)J recombination protein XRCC4. This family consists of several eukaryotic DNA double-strand break repair and V(D)J recombination protein XRCC4 sequences. In the non-homologous end joining pathway of DNA double-strand break repair, the ligation step is catalysed by a complex of XRCC4 and DNA ligase IV. It is thought that XRCC4 and ligase IV are essential for alignment-based gap filling, as well as for final ligation of the breaks.",".",".",".",".","."]
["ENSRNOG00000010423",24,2.019246448,8,0.514643505,3.92358288,1.972171675,0.000301103,0.000254495,"up","yes","Misp","protein_coding","chr7:9870444-9886541:-","gi|157817426|ref|NP_001102754.1|",3033,0,"mitotic interactor and substrate of PLK1 [Rattus norvegicus]","gi|157817425|ref|NM_001109284.1|",2571,0,"Rattus norvegicus mitotic spindle positioning (Misp), mRNA","Q9D279",993,0,"Mitotic interactor and substrate of PLK1",".",".",".",".","pfam15304","AKAP2_C","A-kinase anchor protein 2 C-terminus. This family includes the C-terminus of A-kinase anchor protein 2 (AKAP2). It includes the site where the regulatory subunits (RII) of protein kinase AII binds.","GO:0000132|establishment of mitotic spindle orientation;GO:0016477|cell migration;GO:0051640|organelle localization;GO:0051660|establishment of centrosome localization;GO:0090307|mitotic spindle assembly;GO:1904776|regulation of protein localization to cell cortex;","GO:0005884|actin filament;GO:0005886|plasma membrane;GO:0005925|focal adhesion;GO:0030864|cortical actin cytoskeleton;GO:0031616|spindle pole centrosome;GO:0043231|intracellular membrane-bounded organelle;GO:1905721|mitotic spindle astral microtubule end;","GO:0051015|actin filament binding;",".","."]
["ENSRNOG00000048161",24,2.019246448,8,0.514643505,3.92358288,1.972171675,0.000301103,0.000254495,"up","yes","Tlr9","protein_coding","chr8:106864680-106868796:+","gi|149018685|gb|EDL77326.1|",5007,0,"toll-like receptor 9 [Rattus norvegicus]","gi|37693511|ref|NM_198131.1|",3267,0,"Rattus norvegicus toll-like receptor 9 (Tlr9), mRNA","Q9EQU3",1627,0,"Toll-like receptor 9","alr0124_1",68.6,{"v":5e-11,"d":"5.00E-11"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0001774|microglial cell activation;GO:0001819|positive regulation of cytokine production;GO:0001932|regulation of protein phosphorylation;GO:0002218|activation of innate immune response;GO:0002224|toll-like receptor signaling pathway;GO:0002639|positive regulation of immunoglobulin production;GO:0002730|regulation of dendritic cell cytokine production;GO:0002755|MyD88-dependent toll-like receptor signaling pathway;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0007252|I-kappaB phosphorylation;GO:0008584|male gonad development;GO:0009615|response to virus;GO:0010508|positive regulation of autophagy;GO:0010628|positive regulation of gene expression;GO:0030277|maintenance of gastrointestinal epithelium;GO:0030890|positive regulation of B cell proliferation;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0032715|negative regulation of interleukin-6 production;GO:0032717|negative regulation of interleukin-8 production;GO:0032722|positive regulation of chemokine production;GO:0032725|positive regulation of granulocyte macrophage colony-stimulating factor production;GO:0032727|positive regulation of interferon-alpha production;GO:0032728|positive regulation of interferon-beta production;GO:0032729|positive regulation of interferon-gamma production;GO:0032733|positive regulation of interleukin-10 production;GO:0032735|positive regulation of interleukin-12 production;GO:0032741|positive regulation of interleukin-18 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032757|positive regulation of interleukin-8 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0034122|negative regulation of toll-like receptor signaling pathway;GO:0034123|positive regulation of toll-like receptor signaling pathway;GO:0034162|toll-like receptor 9 signaling pathway;GO:0034163|regulation of toll-like receptor 9 signaling pathway;GO:0034165|positive regulation of toll-like receptor 9 signaling pathway;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043410|positive regulation of MAPK cascade;GO:0043507|positive regulation of JUN kinase activity;GO:0045087|innate immune response;GO:0045577|regulation of B cell differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050727|regulation of inflammatory response;GO:0050729|positive regulation of inflammatory response;GO:0050829|defense response to Gram-negative bacterium;GO:0050864|regulation of B cell activation;GO:0050871|positive regulation of B cell activation;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051607|defense response to virus;GO:0051770|positive regulation of nitric-oxide synthase biosynthetic process;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0071222|cellular response to lipopolysaccharide;GO:0071248|cellular response to metal ion;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1901895|negative regulation of calcium-transporting ATPase activity;GO:1902350|cellular response to chloroquine;","GO:0005737|cytoplasm;GO:0005764|lysosome;GO:0005768|endosome;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0032009|early phagosome;GO:0036019|endolysosome;GO:0045335|phagocytic vesicle;","GO:0003953|NAD+ nucleosidase activity;GO:0004888|transmembrane signaling receptor activity;GO:0005149|interleukin-1 receptor binding;GO:0035197|siRNA binding;GO:0038187|pattern recognition receptor activity;GO:0045322|unmethylated CpG binding;","K10161","TLR9, CD289; toll-like receptor 9"]
["ENSRNOG00000064524",24,2.019246448,8,0.514643505,3.92358288,1.972171675,0.000301103,0.000254495,"up","yes","ENSRNOG00000064524","protein_coding","chr1:65352351-65359807:+","gi|564325681|ref|XP_006228101.1|",2424,0,"PREDICTED: leukocyte immunoglobulin-like receptor subfamily B member 3 isoform X3 [Rattus norvegicus]","gi|672034732|ref|XM_006228039.2|",920,0,"PREDICTED: Rattus norvegicus leukocyte immunoglobulin-like receptor subfamily B member 3-like (LOC100912456), transcript variant X3, mRNA","A0A0G2KBC9",791,0,"Leukocyte immunoglobulin-like receptor subfamily B member 3-like",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.",".",".",".",".","."]
["ENSRNOG00000068366",24,2.019246448,8,0.514643505,3.92358288,1.972171675,0.000301103,0.000254495,"up","yes","U6","snRNA","chr3:16029879-16029985:+","gi|795259358|ref|XP_011810959.1|",127,{"v":4e-08,"d":"4.00E-08"},"PREDICTED: LOW QUALITY PROTEIN: actin, alpha skeletal muscle-like [Colobus angolensis palliatus]","gi|354785713|gb|JN950214.1|",80,{"v":8e-33,"d":"8.00E-33"},"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Kctd13:tm1a(EUCOMM)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam08903","DUF1846","Domain of unknown function (DUF1846). This family of proteins are functionally uncharacterized. Some members of the family are annotated as ATP-dependent peptidases. However, we can find no support for this annotation.",".",".",".",".","."]
["ENSRNOG00000068455",24,2.019246448,8,0.514643505,3.92358288,1.972171675,0.000301103,0.000254495,"up","yes","ENSRNOG00000068455","lncRNA","chr6:101388437-101405067:+",".",".",".",".","gi|672020945|ref|XR_347376.2|",1099,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102552530 (LOC102552530), transcript variant X1, ncRNA",".",".",".",".",".",".",".",".","pfam12846","AAA_10","AAA-like domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.",".",".",".",".","."]
["ENSRNOG00000069321",47,3.954357626,26,1.672591393,2.364210197,1.241358308,0.000302117,0.000255313,"up","yes","Ttc30a","protein_coding","chr3:60901896-60905350:-","gi|407339769|ref|NP_001258423.1|",3473,0,"tetratricopeptide repeat domain 30B [Rattus norvegicus]","gi|407339768|ref|NM_001271494.1|",3455,0,"Rattus norvegicus tetratricopeptide repeat domain 30A (Ttc30a), mRNA","Q99J38",1313,0,"Tetratricopeptide repeat protein 30A1",".",".",".",".","pfam13414","TPR_11","TPR repeat.",".",".",".",".","."]
["ENSRNOG00000062423",28,2.355787522,11,0.70763482,3.329100626,1.735132478,0.000345251,0.000289295,"up","yes","ENSRNOG00000062423","protein_coding","chr1:174986636-174997330:-","gi|153791648|ref|NP_001092955.1|",1454,{"v":1E-175,"d":"1.00E-175"},"vomeronasal 2 receptor, 67 [Rattus norvegicus]","gi|295444890|gb|AC239700.5|",3002,0,"Rattus norvegicus Y Chr BAC RNAEX-240F15 (Amplicon Express Rat SHR-Akr BAC library) complete sequence","E9Q6I0",395,{"v":2e-115,"d":"2.00E-115"},"Vomeronasal type-2 receptor 116",".",".",".",".","pfam00003","7tm_3","7 transmembrane sweet-taste receptor of 3 GCPR. This is a domain of seven transmembrane regions that forms the C-terminus of some subclass 3 G-coupled-protein receptors. It is often associated with a downstream cysteine-rich linker domain, NCD3G pfam07562, which is the human sweet-taste receptor, and the N-terminal domain, ANF_receptor pfam01094. The seven TM regions assemble in such a way as to produce a docking pocket into which such molecules as cyclamate and lactisole have been found to bind and consequently confer the taste of sweetness.",".",".",".",".","."]
["ENSRNOG00000003666",32,2.692328597,14,0.900626135,2.98939648,1.579854253,0.000345618,0.000289514,"up","yes","Jchain","protein_coding","chr14:19538952-19546298:+","gi|149033720|gb|EDL88516.1|",844,{"v":2E-109,"d":"2.00E-109"},"immunoglobulin joining chain [Rattus norvegicus]","gi|67678280|gb|BC097960.1|",1237,0,"Rattus norvegicus immunoglobulin joining chain, mRNA (cDNA clone IMAGE:7384980)","P01592",305,{"v":1e-101,"d":"1.00E-101"},"Immunoglobulin J chain",".",".",".",".","pfam15097","Ig_J_chain","Immunoglobulin J chain.","GO:0001895|retina homeostasis;GO:0002250|adaptive immune response;GO:0003094|glomerular filtration;GO:0019731|antibacterial humoral response;GO:0045087|innate immune response;GO:0060267|positive regulation of respiratory burst;GO:0065003|protein-containing complex assembly;","GO:0005615|extracellular space;GO:0071748|monomeric IgA immunoglobulin complex;GO:0071750|dimeric IgA immunoglobulin complex;GO:0071751|secretory IgA immunoglobulin complex;GO:0071752|secretory dimeric IgA immunoglobulin complex;GO:0071756|pentameric IgM immunoglobulin complex;","GO:0003697|single-stranded DNA binding;GO:0019862|IgA binding;GO:0030674|protein binding, bridging;GO:0031210|phosphatidylcholine binding;GO:0034987|immunoglobulin receptor binding;GO:0042803|protein homodimerization activity;GO:0042834|peptidoglycan binding;",".","."]
["ENSRNOG00000008625",19,1.598570104,5,0.321652191,4.969871648,2.313208593,0.000377201,0.000313845,"up","yes","Rimkla","protein_coding","chr5:133073960-133098792:-","gi|149035428|gb|EDL90109.1|",1910,0,"rCG50366 [Rattus norvegicus]","gi|672019878|ref|XR_146988.3|",2284,0,"PREDICTED: Rattus norvegicus ribosomal modification protein rimK-like family member A (Rimkla), misc_RNA","Q6PFX8",727,0,"N-acetylaspartylglutamate synthase A","MA1361",120,{"v":8e-29,"d":"8.00E-29"},"COG0189","pfam08443","RimK","RimK-like ATP-grasp domain. This ATP-grasp domain is found in the ribosomal S6 modification enzyme RimK.","GO:0006464|cellular protein modification process;","GO:0005737|cytoplasm;","GO:0005524|ATP binding;GO:0046872|metal ion binding;GO:0072590|N-acetyl-L-aspartate-L-glutamate ligase activity;",".","."]
["ENSRNOG00000069308",33,2.776463865,15,0.964956573,2.877294112,1.524712698,0.000398938,0.000330819,"up","yes","ENSRNOG00000069308","lncRNA","chr7:113515332-113519276:+",".",".",".",".","gi|672022159|ref|XR_601933.1|",451,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103692950 (LOC103692950), ncRNA",".",".",".",".",".",".",".",".","pfam14650","FAM75","FAM75 family.",".",".",".",".","."]
["ENSRNOG00000068195",22,1.85097591,7,0.450313067,4.11042016,2.039285871,0.000404908,3.35361E-4,"up","yes","ENSRNOG00000068195","lncRNA","chr7:115343579-115344596:-",".",".",".",".","gi|18855221|emb|AL626769.18|",527,0,"Mouse DNA sequence from clone RP23-23A6 on chromosome 15, complete sequence",".",".",".",".",".",".",".",".","pfam15621","PROL5-SMR","Proline-rich submaxillary gland androgen-regulated family. SMR is a family of proteins found in eukaryotes. The family of SMR proteins is expressed in the submaxillary gland. SMR members may play a role in protection or detoxification.",".",".",".",".","."]
["ENSRNOG00000060193",63,5.300521925,41,2.637547966,2.009640012,1.006937094,0.000408973,3.38625E-4,"up","yes","Prr29","protein_coding","chr10:91305723-91310439:+","gi|34873950|ref|XP_213490.2|",824,{"v":2E-99,"d":"2.00E-99"},"PREDICTED: proline-rich protein 29 [Rattus norvegicus]","gi|672069923|ref|XM_213490.8|",1501,0,"PREDICTED: Rattus norvegicus proline rich 29 (Prr29), mRNA",".",".",".",".",".",".",".",".","pfam15248","DUF4587","Domain of unknown function (DUF4587). This protein family is a domain of unknown function. The precise function of this protein domain remains to be elucidated. This domain family is found in eukaryotes, and is typically between 64 and 79 amino acids in length. There are two conserved sequence motifs: QNAQ and HHH. In humans, it is found in the position, chromosome 21 open reading frame 58.",".",".",".",".","."]
["ENSRNOG00000029179",34,2.860599134,16,1.029287011,2.77920454,1.474672016,0.000454295,0.000373256,"up","yes","Cyp2d3","protein_coding","chr7:113908947-113922084:-","gi|23463315|ref|NP_695225.1|",1979,0,"cytochrome P450 2D1 [Rattus norvegicus]","gi|298911525|emb|FQ219613.1|",1277,0,"Rattus norvegicus TL0ABA44YB23 mRNA sequence","P10633",763,0,"Cytochrome P450 2D1",".",".",".",".","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0001889|liver development;GO:0006082|organic acid metabolic process;GO:0006805|xenobiotic metabolic process;GO:0009410|response to xenobiotic stimulus;GO:0010033|response to organic substance;GO:0014070|response to organic cyclic compound;GO:0019369|arachidonic acid metabolic process;GO:0042178|xenobiotic catabolic process;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0004497|monooxygenase activity;GO:0005506|iron ion binding;GO:0008395|steroid hydroxylase activity;GO:0016712|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0020037|heme binding;GO:0070330|aromatase activity;","K07414","CYP2D; cytochrome P450 family 2 subfamily D [EC:1.14.14.1]"]
["ENSRNOG00000048967",34,2.860599134,16,1.029287011,2.77920454,1.474672016,0.000454295,0.000373256,"up","yes","ENSRNOG00000048967","protein_coding","chr9:20024916-20029094:+","gi|157819141|ref|NP_001102972.1|",858,{"v":5e-111,"d":"5.00E-111"},"uncharacterized protein C6orf141 homolog [Rattus norvegicus]","gi|157819140|ref|NM_001109502.1|",1305,0,"Rattus norvegicus hypothetical protein LOC688459 (LOC688459), mRNA",".",".",".",".",".",".",".",".","pfam10446","DUF2457","Protein of unknown function (DUF2457). This is a family of uncharacterized proteins.","GO:0001835|blastocyst hatching;",".",".",".","."]
["ENSRNOG00000008960",46,3.870222358,26,1.672591393,2.313907852,1.210331413,4.57861E-4,0.000376016,"up","yes","Fgf22","protein_coding","chr7:9948071-9950486:-","gi|18543363|ref|NP_570107.1|",717,{"v":3e-91,"d":"3.00E-91"},"fibroblast growth factor 22 precursor [Rattus norvegicus]","gi|88608890|gb|AC131405.5|",551,0,"Rattus norvegicus BAC CH230-179I7 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q9ESS2",274,{"v":3e-90,"d":"3.00E-90"},"Fibroblast growth factor 22",".",".",".",".","pfam00167","FGF","Fibroblast growth factor. Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide range of contexts. They are found in a wide range of organisms, from nematodes to humans. Most share an internal core region of high similarity, conserved residues in which are involved in binding with their receptors. On binding, they cause dimerization of their tyrosine kinase receptors leading to intracellular signalling. There are currently four known tyrosine kinase receptors for fibroblast growth factors. These receptors can each bind several different members of this family. Members of this family have a beta trefoil structure. Most have N-terminal signal peptides and are secreted. A few lack signal sequences but are secreted anyway; still others also lack the signal peptide but are found on the cell surface and within the extracellular matrix. A third group remain intracellular. They have central roles in development, regulating cell proliferation, migration and differentiation. On the other hand, they are important in tissue repair following injury in adult organisms.","GO:0001934|positive regulation of protein phosphorylation;GO:0008284|positive regulation of cell proliferation;GO:0008543|fibroblast growth factor receptor signaling pathway;GO:0009887|animal organ morphogenesis;GO:0010628|positive regulation of gene expression;GO:0030154|cell differentiation;GO:0030334|regulation of cell migration;","GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0009986|cell surface;","GO:0005104|fibroblast growth factor receptor binding;GO:0008083|growth factor activity;","K04358","FGF; fibroblast growth factor"]
["ENSRNOG00000012008",17,1.430299567,4,0.257321753,5.55840908,2.474672016,0.000467558,0.000383458,"up","yes","S100a3","protein_coding","chr2:176049520-176089702:+","gi|564336996|ref|XP_006232620.1|",497,{"v":3e-59,"d":"3.00E-59"},"PREDICTED: protein S100-A3 isoform X2 [Rattus norvegicus]","gi|672042834|ref|XM_006232558.2|",872,0,"PREDICTED: Rattus norvegicus S100 calcium binding protein A3 (S100a3), transcript variant X1, mRNA","P62819",172,{"v":8e-52,"d":"8.00E-52"},"Protein S100-A3",".",".",".",".","pfam01023","S_100","S-100/ICaBP type calcium binding domain. The S-100 domain is a subfamily of the EF-hand calcium binding proteins.",".","GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0005509|calcium ion binding;GO:0008270|zinc ion binding;GO:0048306|calcium-dependent protein binding;","K23760","S100A3, S100E; protein S100-A3"]
["ENSRNOG00000067138",17,1.430299567,4,0.257321753,5.55840908,2.474672016,0.000467558,0.000383458,"up","yes","Tlr10","protein_coding","chr14:43406217-43413917:+","gi|564383756|ref|XP_006251064.1|",4139,0,"PREDICTED: toll-like receptor 10 isoform X1 [Rattus norvegicus]","gi|672076174|ref|XM_006251002.2|",2555,0,"PREDICTED: Rattus norvegicus toll-like receptor 10 (Tlr10), transcript variant X1, mRNA","Q9BXR5",1130,0,"Toll-like receptor 10",".",".",".",".","pfam01582","TIR","TIR domain. The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.",".",".",".",".","."]
["ENSRNOG00000011550",26,2.187516985,10,0.643304382,3.400438496,1.765720798,4.81569E-4,3.94177E-4,"up","yes","Kcnab2","protein_coding","chr5:162901896-162988243:-","gi|568930660|ref|XP_006538649.1|",1699,0,"PREDICTED: voltage-gated potassium channel subunit beta-2 isoform X6 [Mus musculus]","gi|755509316|ref|XM_006538587.2|",677,0,"PREDICTED: Mus musculus potassium voltage-gated channel, shaker-related subfamily, beta member 2 (Kcnab2), transcript variant X10, mRNA","P62483",605,0,"Voltage-gated potassium channel subunit beta-2","TM0313",262,{"v":4e-81,"d":"4.00E-81"},"COG0667","pfam00248","Aldo_ket_red","Aldo/keto reductase family. This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.","GO:0002244|hematopoietic progenitor cell differentiation;GO:0045445|myoblast differentiation;GO:0050905|neuromuscular process;GO:0070995|NADPH oxidation;GO:0071805|potassium ion transmembrane transport;GO:0098900|regulation of action potential;GO:1901379|regulation of potassium ion transmembrane transport;GO:2000008|regulation of protein localization to cell surface;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005874|microtubule;GO:0008076|voltage-gated potassium channel complex;GO:0014069|postsynaptic density;GO:0016020|membrane;GO:0030424|axon;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0034705|potassium channel complex;GO:0043005|neuron projection;GO:0043679|axon terminus;GO:0044224|juxtaparanode region of axon;GO:1990031|pinceau fiber;","GO:0004033|aldo-keto reductase (NADP) activity;GO:0005249|voltage-gated potassium channel activity;GO:0005515|protein binding;GO:0015459|potassium channel regulator activity;GO:0044325|ion channel binding;GO:0044877|protein-containing complex binding;GO:0047834|D-threo-aldose 1-dehydrogenase activity;","K04883","KCNAB2; potassium voltage-gated channel Shaker-related subfamily A, beta member 2"]
["ENSRNOG00000015850",26,2.187516985,10,0.643304382,3.400438496,1.765720798,4.81569E-4,3.94177E-4,"up","yes","Rbp7","protein_coding","chr5:159889723-159894339:-","gi|157822745|ref|NP_001102163.1|",543,{"v":3e-67,"d":"3.00E-67"},"retinoid-binding protein 7 [Rattus norvegicus]","gi|157822744|ref|NM_001108693.1|",500,0,"Rattus norvegicus retinol binding protein 7 (Rbp7), mRNA","Q9EPC5",201,{"v":9e-64,"d":"9.00E-64"},"Retinoid-binding protein 7",".",".",".",".","pfam01146","Caveolin","Caveolin. All three known Caveolin forms have the FEDVIAEP caveolin 'signature motif' within their hydrophilic N-terminal domain. Caveolin 2 (Cav-2) is co-localized and co-expressed with Cav-1/VIP21, forms heterodimers with it and needs Cav-1 for proper membrane localisation. Cav-3 has greater protein sequence similarity to Cav-1 than to Cav-2. Cellular processes caveolins are involved in include vesicular transport, cholesterol homeostasis, signal transduction, and tumor suppression.",".",".","GO:0005501|retinoid binding;",".","."]
["ENSRNOG00000006998",40,3.365410746,21,1.350939202,2.491163733,1.316819847,0.000482569,0.000394877,"up","yes","Fhl4","protein_coding","chr7:18598103-18635184:+","gi|564358781|ref|XP_006241241.1|",1465,0,"PREDICTED: four and a half LIM domains 4 isoform X1 [Rattus norvegicus]","gi|354791984|gb|JN956485.1|",2029,0,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Fhl4:tm1e(EUCOMM)Hmgu; transgenic","Q9WUH4",421,{"v":8e-134,"d":"8.00E-134"},"Four and a half LIM domains protein 1",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.","GO:0007517|muscle organ development;",".","GO:0044325|ion channel binding;GO:0046872|metal ion binding;",".","."]
["ENSRNOG00000026217",56,4.711575044,35,2.251565336,2.092577536,1.06528108,0.000483552,0.000395563,"up","yes","Armc2","protein_coding","chr20:45394127-45504819:-","gi|564398283|ref|XP_574794.3|",4452,0,"PREDICTED: armadillo repeat-containing protein 2 isoform X2 [Rattus norvegicus]","gi|672086772|ref|XM_574794.4|",2951,0,"PREDICTED: Rattus norvegicus armadillo repeat containing 2 (Armc2), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam15449","Retinal","Retinal protein. This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.","GO:0007288|sperm axoneme assembly;GO:0044782|cilium organization;",".",".","K24123","ARMC2; armadillo repeat-containing protein 2"]
["ENSRNOG00000004150",30,2.524058059,13,0.836295696,3.018140677,1.593660052,0.00048891,0.000399586,"up","yes","Slc9a7","protein_coding","chrX:2214441-2388012:+","gi|564398462|ref|XP_006256698.1|",3144,0,"PREDICTED: sodium/hydrogen exchanger 7 isoform X1 [Rattus norvegicus]","gi|672086857|ref|XM_006256636.2|",2554,0,"PREDICTED: Rattus norvegicus solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 (Slc9a7), transcript variant X1, mRNA","Q8BLV3",1192,0,"Sodium/hydrogen exchanger 7","YDR456w",243,{"v":2e-68,"d":"2.00E-68"},"COG0025","pfam00999","Na_H_Exchanger","Sodium/hydrogen exchanger family. Na/H antiporters are key transporters in maintaining the pH of actively metabolizing cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.","GO:0006885|regulation of pH;GO:0051453|regulation of intracellular pH;GO:0071805|potassium ion transmembrane transport;GO:0098656|anion transmembrane transport;GO:0098719|sodium ion import across plasma membrane;GO:1902600|proton transmembrane transport;GO:1905526|regulation of Golgi lumen acidification;","GO:0005802|trans-Golgi network;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0055037|recycling endosome;GO:0055038|recycling endosome membrane;","GO:0015385|sodium:proton antiporter activity;GO:0015386|potassium:proton antiporter activity;",".","."]
["ENSRNOG00000007625",10,0.841352686,0,0.032165219,26.1572192,4.70913727,0.000526459,0.000427579,"up","yes","B3galt1","protein_coding","chr3:52253618-52825313:+","gi|585161461|ref|XP_006732944.1|",1797,0,"PREDICTED: beta-1,3-galactosyltransferase 1 [Leptonychotes weddellii]","gi|157822402|ref|NM_001108954.1|",2617,0,"Rattus norvegicus Beta-1,3-galactosyltransferase 1 (B3galt1), mRNA","Q9MYM7",685,0,"Beta-1,3-galactosyltransferase 1",".",".",".",".","pfam01762","Galactosyl_T","Galactosyltransferase. This family includes the galactosyltransferases UDP-galactose:2-acetamido-2-deoxy-D-glucose3beta-galactosyltransferase and UDP-Gal:beta-GlcNAc beta 1,3-galactosyltranferase. Specific galactosyltransferases transfer galactose to GlcNAc terminal chains in the synthesis of the lacto-series oligosaccharides types 1 and 2.","GO:0006486|protein glycosylation;GO:0006682|galactosylceramide biosynthetic process;GO:0009312|oligosaccharide biosynthetic process;GO:0030259|lipid glycosylation;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0008194|UDP-glycosyltransferase activity;GO:0008499|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity;GO:0016757|transferase activity, transferring glycosyl groups;","K07819","B3GALT1; beta-1,3-galactosyltransferase 1 [EC:2.4.1.86]"]
["ENSRNOG00000015788",10,0.841352686,0,0.032165219,26.1572192,4.70913727,0.000526459,0.000427579,"up","yes","Adora3","protein_coding","chr2:193388713-193392357:+","gi|713693919|ref|NP_001289684.1|",1762,0,"adenosine receptor A3 isoform a [Rattus norvegicus]","gi|713693918|ref|NM_001302755.1|",1815,0,"Rattus norvegicus adenosine A3 receptor (Adora3), transcript variant A3i, mRNA","P28647",618,0,"Adenosine receptor A3",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001973|adenosine receptor signaling pathway;GO:0008285|negative regulation of cell proliferation;GO:0030336|negative regulation of cell migration;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0098685|Schaffer collateral - CA1 synapse;","GO:0001609|G protein-coupled adenosine receptor activity;GO:0004888|transmembrane signaling receptor activity;","K04268","ADORA3; adenosine receptor A3"]
["ENSRNOG00000020080",10,0.841352686,0,0.032165219,26.1572192,4.70913727,0.000526459,0.000427579,"up","yes","Lrrc18","protein_coding","chr16:8254352-8277437:+","gi|148692902|gb|EDL24849.1|",1342,0,"leucine rich repeat containing 18, partial [Mus musculus]","gi|62078726|ref|NM_001013999.1|",1512,0,"Rattus norvegicus leucine rich repeat containing 18 (Lrrc18), mRNA","Q66HD6",518,0,"Leucine-rich repeat-containing protein 18","alr0124_1",92.4,{"v":3e-19,"d":"3.00E-19"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.",".","GO:0005737|cytoplasm;",".",".","."]
["ENSRNOG00000051600",10,0.841352686,0,0.032165219,26.1572192,4.70913727,0.000526459,0.000427579,"up","yes","Ly49i4","protein_coding","chr4:164122072-164341692:-","gi|57222302|ref|NP_001009487.1|",1414,0,"Ly49 stimulatory receptor 4 [Rattus norvegicus]","gi|57222301|ref|NM_001009487.1|",1260,0,"Rattus norvegicus Ly49 stimulatory receptor 4 (Ly49s4), mRNA","Q60652",281,{"v":9e-90,"d":"9.00E-90"},"Killer cell lectin-like receptor 5",".",".",".",".","pfam08391","Ly49","Ly49-like protein, N-terminal region. The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).","GO:0009968|negative regulation of signal transduction;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;","GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0005515|protein binding;GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000054129",10,0.841352686,0,0.032165219,26.1572192,4.70913727,0.000526459,0.000427579,"up","yes","Ctla4","protein_coding","chr9:62319312-62324963:+","gi|149046030|gb|EDL98923.1|",1186,{"v":2e-162,"d":"2.00E-162"},"cytotoxic T-lymphocyte-associated protein 4, isoform CRA_a [Rattus norvegicus]","gi|13928933|ref|NM_031674.1|",715,0,"Rattus norvegicus cytotoxic T-lymphocyte-associated protein 4 (Ctla4), mRNA","P09793",417,{"v":1E-146,"d":"1.00E-146"},"Cytotoxic T-lymphocyte protein 4",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0006955|immune response;GO:0006974|cellular response to DNA damage stimulus;GO:0030889|negative regulation of B cell proliferation;GO:0042130|negative regulation of T cell proliferation;GO:0043065|positive regulation of apoptotic process;GO:0045590|negative regulation of regulatory T cell differentiation;GO:0050777|negative regulation of immune response;GO:0050852|T cell receptor signaling pathway;GO:0050853|B cell receptor signaling pathway;","GO:0005575|cellular_component;GO:0005794|Golgi apparatus;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0045334|clathrin-coated endocytic vesicle;GO:0048471|perinuclear region of cytoplasm;GO:0098636|protein complex involved in cell adhesion;","GO:0005515|protein binding;GO:0038023|signaling receptor activity;","K06538","CTLA4, CD152; cytotoxic T-lymphocyte-associated protein 4"]
["ENSRNOG00000064495",10,0.841352686,0,0.032165219,26.1572192,4.70913727,0.000526459,0.000427579,"up","yes","ENSRNOG00000064495","lncRNA","chr19:52912680-52915635:+","gi|149036607|gb|EDL91225.1|",229,{"v":2E-19,"d":"2.00E-19"},"rCG56442 [Rattus norvegicus]","gi|111038150|gb|AC132998.5|",164,{"v":4E-78,"d":"4.00E-78"},"Rattus norvegicus BAC CH230-6L10 () complete sequence","P46935",54.3,{"v":3e-06,"d":"3.00E-06"},"E3 ubiquitin-protein ligase NEDD4",".",".",".",".",".",".",".",".",".",".",".","."]
["ENSRNOG00000006784",23,1.935111179,8,0.514643505,3.76010026,1.910771131,0.000530704,0.000430705,"up","yes","Sema4f","protein_coding","chr4:115411417-115437721:-","gi|9507083|ref|NP_062145.1|",3424,0,"semaphorin-4F precursor [Rattus norvegicus]","gi|9507082|ref|NM_019272.1|",3973,0,"Rattus norvegicus ssemaphorin 4F (Sema4f), mRNA","Q9Z143",1323,0,"Semaphorin-4F",".",".",".",".","pfam01403","Sema","Sema domain. The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and human plexin A-3.","GO:0001755|neural crest cell migration;GO:0007411|axon guidance;GO:0030335|positive regulation of cell migration;GO:0030517|negative regulation of axon extension;GO:0031290|retinal ganglion cell axon guidance;GO:0048843|negative regulation of axon extension involved in axon guidance;GO:0050919|negative chemotaxis;GO:0071526|semaphorin-plexin signaling pathway;","GO:0005615|extracellular space;GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0014069|postsynaptic density;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0043204|perikaryon;GO:0045202|synapse;GO:0045211|postsynaptic membrane;","GO:0030215|semaphorin receptor binding;GO:0045499|chemorepellent activity;","K06521","SEMA4, CD100; semaphorin 4"]
["ENSRNOG00000031443",20,1.682705373,6,0.385982629,4.359536534,2.124174769,0.000537472,0.000435938,"up","yes","Havcr2","protein_coding","chr10:30882606-30909137:+","gi|158508553|ref|NP_001094232.1|",1067,{"v":9e-135,"d":"9.00E-135"},"hepatitis A virus cellular receptor 2 homolog precursor [Rattus norvegicus]","gi|158508552|ref|NM_001100762.1|",2763,0,"Rattus norvegicus hepatitis A virus cellular receptor 2 (Havcr2), mRNA","P0C0K5",415,{"v":3e-136,"d":"3.00E-136"},"Hepatitis A virus cellular receptor 2 homolog",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0001819|positive regulation of cytokine production;GO:0002250|adaptive immune response;GO:0002281|macrophage activation involved in immune response;GO:0002519|natural killer cell tolerance induction;GO:0002652|regulation of tolerance induction dependent upon immune response;GO:0002826|negative regulation of T-helper 1 type immune response;GO:0002838|negative regulation of immune response to tumor cell;GO:0002859|negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target;GO:0006954|inflammatory response;GO:0008150|biological_process;GO:0010629|negative regulation of gene expression;GO:0030886|negative regulation of myeloid dendritic cell activation;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0032480|negative regulation of type I interferon production;GO:0032687|negative regulation of interferon-alpha production;GO:0032689|negative regulation of interferon-gamma production;GO:0032703|negative regulation of interleukin-2 production;GO:0032712|negative regulation of interleukin-3 production;GO:0032715|negative regulation of interleukin-6 production;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032722|positive regulation of chemokine production;GO:0032729|positive regulation of interferon-gamma production;GO:0032732|positive regulation of interleukin-1 production;GO:0032753|positive regulation of interleukin-4 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032815|negative regulation of natural killer cell activation;GO:0034138|toll-like receptor 3 signaling pathway;GO:0034154|toll-like receptor 7 signaling pathway;GO:0034162|toll-like receptor 9 signaling pathway;GO:0042102|positive regulation of T cell proliferation;GO:0042130|negative regulation of T cell proliferation;GO:0043032|positive regulation of macrophage activation;GO:0045087|innate immune response;GO:0045089|positive regulation of innate immune response;GO:0045824|negative regulation of innate immune response;GO:0050830|defense response to Gram-positive bacterium;GO:0060135|maternal process involved in female pregnancy;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071222|cellular response to lipopolysaccharide;GO:0071656|negative regulation of granulocyte colony-stimulating factor production;GO:1900425|negative regulation of defense response to bacterium;GO:1900426|positive regulation of defense response to bacterium;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:2000521|negative regulation of immunological synapse formation;GO:2001189|negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;","GO:0001772|immunological synapse;GO:0005769|early endosome;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0030054|cell junction;","GO:0003674|molecular_function;GO:0046872|metal ion binding;","K20414","HAVCR2, CD366; hepatitis A virus cellular receptor 2"]
["ENSRNOG00000046155",20,1.682705373,6,0.385982629,4.359536534,2.124174769,0.000537472,0.000435938,"up","yes","ENSRNOG00000046155","protein_coding","chr8:109036030-109097895:+","gi|202070754|ref|NP_001128484.1|",4968,0,"ubiquitin carboxyl-terminal hydrolase 4 isoform a [Rattus norvegicus]","gi|202070753|ref|NM_001135012.1|",3886,0,"Rattus norvegicus ubiquitin specific peptidase 4 (proto-oncogene) (Usp4), transcript variant 1, mRNA","B2GUZ1",1918,0,"Ubiquitin carboxyl-terminal hydrolase 4","SPCC1494.05c",249,{"v":7e-67,"d":"7.00E-67"},"COG5560","pfam00443","UCH","Ubiquitin carboxyl-terminal hydrolase.",".",".",".",".","."]
["ENSRNOG00000017485",49,4.122628164,29,1.865582707,2.209834036,1.143938024,0.000544418,4.40915E-4,"up","yes","Cd72","protein_coding","chr5:57697367-57704725:-","gi|62543519|ref|NP_001015016.1|",1653,0,"B-cell differentiation antigen CD72 [Rattus norvegicus]","gi|62543518|ref|NM_001015016.1|",1473,0,"Rattus norvegicus Cd72 molecule (Cd72), mRNA","P21855",396,{"v":4e-133,"d":"4.00E-133"},"B-cell differentiation antigen CD72",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type",".","GO:0005887|integral component of plasma membrane;","GO:0004888|transmembrane signaling receptor activity;","K06504","CD72; CD72 antigen"]
["ENSRNOG00000011205",15,1.26202903,3,0.192991315,6.5393048,2.70913727,0.000551169,0.000445786,"up","yes","Ccl3","protein_coding","chr10:68451388-68452938:-","gi|40254794|ref|NP_037157.2|",493,{"v":8e-60,"d":"8.00E-60"},"C-C motif chemokine 3 precursor [Rattus norvegicus]","gi|40254793|ref|NM_013025.2|",751,0,"Rattus norvegicus chemokine (C-C motif) ligand 3 (Ccl3), mRNA","P50229",194,{"v":3e-61,"d":"3.00E-61"},"C-C motif chemokine 3",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0000165|MAPK cascade;GO:0001649|osteoblast differentiation;GO:0001775|cell activation;GO:0002548|monocyte chemotaxis;GO:0006468|protein phosphorylation;GO:0006816|calcium ion transport;GO:0006874|cellular calcium ion homeostasis;GO:0006887|exocytosis;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0007010|cytoskeleton organization;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007267|cell-cell signaling;GO:0008360|regulation of cell shape;GO:0009410|response to xenobiotic stimulus;GO:0009636|response to toxic substance;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010818|T cell chemotaxis;GO:0014808|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0019722|calcium-mediated signaling;GO:0023052|signaling;GO:0030335|positive regulation of cell migration;GO:0030502|negative regulation of bone mineralization;GO:0030593|neutrophil chemotaxis;GO:0030595|leukocyte chemotaxis;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0032731|positive regulation of interleukin-1 beta production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0043308|eosinophil degranulation;GO:0043491|protein kinase B signaling;GO:0043525|positive regulation of neuron apoptotic process;GO:0043547|positive regulation of GTPase activity;GO:0043615|astrocyte cell migration;GO:0043922|negative regulation by host of viral transcription;GO:0045671|negative regulation of osteoclast differentiation;GO:0045672|positive regulation of osteoclast differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048245|eosinophil chemotaxis;GO:0048246|macrophage chemotaxis;GO:0048247|lymphocyte chemotaxis;GO:0050729|positive regulation of inflammatory response;GO:0050795|regulation of behavior;GO:0050850|positive regulation of calcium-mediated signaling;GO:0050918|positive chemotaxis;GO:0051897|positive regulation of protein kinase B signaling;GO:0051928|positive regulation of calcium ion transport;GO:0051930|regulation of sensory perception of pain;GO:0070098|chemokine-mediated signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070723|response to cholesterol;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0071407|cellular response to organic cyclic compound;GO:0071621|granulocyte chemotaxis;GO:2000503|positive regulation of natural killer cell chemotaxis;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004672|protein kinase activity;GO:0004698|calcium-dependent protein kinase C activity;GO:0008009|chemokine activity;GO:0008201|heparin binding;GO:0016004|phospholipase activator activity;GO:0016301|kinase activity;GO:0031726|CCR1 chemokine receptor binding;GO:0031730|CCR5 chemokine receptor binding;GO:0042056|chemoattractant activity;GO:0042802|identical protein binding;GO:0048020|CCR chemokine receptor binding;","K05408","CCL3; C-C motif chemokine 3"]
["ENSRNOG00000063449",15,1.26202903,3,0.192991315,6.5393048,2.70913727,0.000551169,0.000445786,"up","yes","ENSRNOG00000063449","lncRNA","chr7:110021779-110033215:+","gi|149062508|gb|EDM12931.1|",205,{"v":3e-27,"d":"3.00E-27"},"ciliary neurotrophic factor, isoform CRA_d [Rattus norvegicus]","gi|672060355|ref|XR_593644.1|",1737,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102547102 (LOC102547102), transcript variant X5, ncRNA",".",".",".",".",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.",".",".",".",".","."]
["ENSRNOG00000067465",15,1.26202903,3,0.192991315,6.5393048,2.70913727,0.000551169,0.000445786,"up","yes","ENSRNOG00000067465","lncRNA","chr3:115420794-115422432:-","gi|149023241|gb|EDL80135.1|",310,{"v":4e-33,"d":"4.00E-33"},"rCG26742 [Rattus norvegicus]","gi|672017319|ref|XR_345178.2|",694,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102555660 (LOC102555660), transcript variant X2, ncRNA",".",".",".",".",".",".",".",".","pfam08491","SE","Squalene epoxidase. This domain is found in squalene epoxidase (SE) and related proteins which are found in taxonomically diverse groups of eukaryotes and also in bacteria.  SE was first cloned from Saccharomyces cerevisiae where it was named ERG1. It contains a putative FAD binding site and is a key enzyme in the sterol biosynthetic pathway. Putative transmembrane regions are found to the protein's C-terminus.",".",".",".",".","."]
["ENSRNOG00000019022",11,0.925487955,1,0.064330438,14.38647056,3.846640793,0.000562724,0.000454321,"up","yes","Fam89a","protein_coding","chr19:52710019-52722631:-","gi|58743349|ref|NP_001011711.1|",569,{"v":2e-67,"d":"2.00E-67"},"protein FAM89A [Rattus norvegicus]","gi|79152851|gb|BC107921.1|",1370,0,"Rattus norvegicus family with sequence similarity 89, member A, mRNA (cDNA clone MGC:124908 IMAGE:7445343), complete cds",".",".",".",".",".",".",".",".","pfam07816","DUF1645","Protein of unknown function (DUF1645). These sequences are derived from a number of hypothetical plant proteins. The region in question is approximately 270 amino acids long. Some members of this family are annotated as yeast pheromone receptor proteins AR781 but no literature was found to support this.",".",".",".",".","."]
["ENSRNOG00000033588",11,0.925487955,1,0.064330438,14.38647056,3.846640793,0.000562724,0.000454321,"up","yes","Siglec15","protein_coding","chr18:71505399-71521881:-","gi|300794395|ref|NP_001178871.1|",1522,0,"sialic acid-binding Ig-like lectin 15 precursor [Rattus norvegicus]","gi|300794394|ref|NM_001191942.1|",1026,0,"Rattus norvegicus sialic acid binding Ig-like lectin 15 (Siglec15), mRNA","Q6ZMC9",446,{"v":1e-144,"d":"1.00E-144"},"Sialic acid-binding Ig-like lectin 15",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0032956|regulation of actin cytoskeleton organization;GO:0045124|regulation of bone resorption;GO:2001204|regulation of osteoclast development;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0032991|protein-containing complex;",".","K16352","SIGLEC15; sialic acid binding Ig-like lectin 15"]
["ENSRNOG00000035466",11,0.925487955,1,0.064330438,14.38647056,3.846640793,0.000562724,0.000454321,"up","yes","Mir146a","miRNA","chr10:27848516-27848610:-","gi|432098875|gb|ELK28370.1|",121,{"v":2e-07,"d":"2.00E-07"},"Ras-related protein Rab-5C [Myotis davidii]","gi|296923643|ref|NR_031892.1|",95,{"v":3e-41,"d":"3.00E-41"},"Rattus norvegicus microRNA 146a (Mir146a), microRNA",".",".",".",".",".",".",".",".","pfam07342","DUF1474","Protein of unknown function (DUF1474). This family consists of several bacterial proteins of around 100 residues in length. Members of this family seem to be found exclusively in Staphylococcus aureus. The function of this family is unknown.","GO:0007605|sensory perception of sound;GO:0010468|regulation of gene expression;GO:0036294|cellular response to decreased oxygen levels;GO:0070482|response to oxygen levels;GO:0071222|cellular response to lipopolysaccharide;GO:0071391|cellular response to estrogen stimulus;GO:1990830|cellular response to leukemia inhibitory factor;","GO:0045202|synapse;",".","K17012","MIR146A; microRNA 146a"]
["ENSRNOG00000056184",31,2.608193328,14,0.900626135,2.89597784,1.534050563,0.000566332,0.000456693,"up","yes","Lrp2","protein_coding","chr3:54189308-54346708:-","gi|149022162|gb|EDL79056.1|",23985,0,"rCG26871, isoform CRA_a [Rattus norvegicus]","gi|13562117|ref|NM_030827.1|",15198,0,"Rattus norvegicus LDL receptor related protein 2 (Lrp2), mRNA","P98158",9238,0,"Low-density lipoprotein receptor-related protein 2",".",".",".",".","pfam00057","Ldl_recept_a","Low-density lipoprotein receptor domain class A.","GO:0001822|kidney development;GO:0001843|neural tube closure;GO:0003139|secondary heart field specification;GO:0003148|outflow tract septum morphogenesis;GO:0003223|ventricular compact myocardium morphogenesis;GO:0003281|ventricular septum development;GO:0006766|vitamin metabolic process;GO:0006897|endocytosis;GO:0006898|receptor-mediated endocytosis;GO:0007507|heart development;GO:0007568|aging;GO:0007605|sensory perception of sound;GO:0008283|cell proliferation;GO:0008584|male gonad development;GO:0009410|response to xenobiotic stimulus;GO:0010165|response to X-ray;GO:0010951|negative regulation of endopeptidase activity;GO:0015031|protein transport;GO:0016197|endosomal transport;GO:0020028|endocytic hemoglobin import;GO:0030001|metal ion transport;GO:0030514|negative regulation of BMP signaling pathway;GO:0030900|forebrain development;GO:0031100|animal organ regeneration;GO:0032526|response to retinoic acid;GO:0033280|response to vitamin D;GO:0035904|aorta development;GO:0043066|negative regulation of apoptotic process;GO:0044321|response to leptin;GO:0045056|transcytosis;GO:0045807|positive regulation of endocytosis;GO:0046879|hormone secretion;GO:0050769|positive regulation of neurogenesis;GO:0051897|positive regulation of protein kinase B signaling;GO:0060068|vagina development;GO:0060976|coronary vasculature development;GO:0060982|coronary artery morphogenesis;GO:0061156|pulmonary artery morphogenesis;GO:0061642|chemoattraction of axon;GO:0070447|positive regulation of oligodendrocyte progenitor proliferation;GO:0071363|cellular response to growth factor stimulus;GO:0097242|amyloid-beta clearance;GO:0140058|neuron projection arborization;GO:0140077|positive regulation of lipoprotein transport;GO:1904447|folate import across plasma membrane;GO:1905167|positive regulation of lysosomal protein catabolic process;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005903|brush border;GO:0005905|clathrin-coated pit;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0030139|endocytic vesicle;GO:0030424|axon;GO:0030425|dendrite;GO:0031526|brush border membrane;GO:0031904|endosome lumen;GO:0032991|protein-containing complex;GO:0043235|receptor complex;GO:0044295|axonal growth cone;GO:0045121|membrane raft;GO:0045177|apical part of cell;","GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0016922|nuclear receptor binding;GO:0017124|SH3 domain binding;GO:0030165|PDZ domain binding;GO:0030492|hemoglobin binding;GO:0031994|insulin-like growth factor I binding;GO:0038023|signaling receptor activity;GO:0042562|hormone binding;GO:0044877|protein-containing complex binding;GO:0050750|low-density lipoprotein particle receptor binding;GO:0051087|chaperone binding;","K06233","LRP2; low density lipoprotein-related protein 2"]
["ENSRNOG00000069413",31,2.608193328,14,0.900626135,2.89597784,1.534050563,0.000566332,0.000456693,"up","yes","S100a14","protein_coding","chr2:176008395-176010423:+","gi|537264389|gb|ERE90683.1|",580,{"v":2e-69,"d":"2.00E-69"},"EF-hand-like domain containing protein [Cricetulus griseus]","gi|672015977|ref|XM_002725995.4|",1081,0,"PREDICTED: Rattus norvegicus S100 calcium binding protein A14 (S100a14), transcript variant X1, mRNA","Q9D2Q8",210,{"v":9e-66,"d":"9.00E-66"},"Protein S100-A14",".",".",".",".","pfam01023","S_100","S-100/ICaBP type calcium binding domain. The S-100 domain is a subfamily of the EF-hand calcium binding proteins.",".",".",".",".","."]
["ENSRNOG00000038197",13,1.093758492,2,0.128660876,8.50109624,3.087648893,0.000597684,0.000480339,"up","yes","Cd226","protein_coding","chr18:82450568-82543051:+","gi|157817173|ref|NP_001100840.1|",1734,0,"CD226 antigen precursor [Rattus norvegicus]","gi|157817172|ref|NM_001107370.1|",2312,0,"Rattus norvegicus CD226 molecule (Cd226), mRNA","Q8K4F0",552,0,"CD226 antigen",".",".",".",".","pfam10565","NMDAR2_C","N-methyl D-aspartate receptor 2B3 C-terminus. This domain is found at the C-terminus of many NMDA-receptor proteins, many of which also carry the Ligated ion-channel family pfam00060 further upstream as well as the ANF_receptor family pfam01094. This region is predicted to be a large extra-cellular domain of the NMDA receptor proteins, being highly hydrophilic, and is thought to be integrally involved in the function of the receptor. The region also carries a number of potential N-glycosylation sites.","GO:0001816|cytokine production;GO:0002729|positive regulation of natural killer cell cytokine production;GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target;GO:0002891|positive regulation of immunoglobulin mediated immune response;GO:0008150|biological_process;GO:0032729|positive regulation of interferon-gamma production;GO:0033005|positive regulation of mast cell activation;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;GO:0050862|positive regulation of T cell receptor signaling pathway;GO:0060369|positive regulation of Fc receptor mediated stimulatory signaling pathway;","GO:0005575|cellular_component;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0005178|integrin binding;GO:0019901|protein kinase binding;GO:0050839|cell adhesion molecule binding;","K06567","CD226, DNAM1; CD226 antigen"]
["ENSRNOG00000057245",13,1.093758492,2,0.128660876,8.50109624,3.087648893,0.000597684,0.000480339,"up","yes","Rbbp8nl","protein_coding","chr3:167364048-167379092:-","gi|672017875|ref|XP_008773863.1|",2549,0,"PREDICTED: RBBP8 N-terminal-like protein [Rattus norvegicus]","gi|672017874|ref|XM_008775641.1|",2017,0,"PREDICTED: Rattus norvegicus RBBP8 N-terminal like (Rbbp8nl), mRNA","Q8NC74",466,{"v":2e-148,"d":"2.00E-148"},"RBBP8 N-terminal-like protein",".",".",".",".","pfam10482","CtIP_N","tumor-suppressor protein CtIP N-terminal domain. CtIP is predominantly a nuclear protein that complexes with both BRCA1 and the BRCA1-associated RING domain protein (BARD1). At the protein level, CtIP expression varies with cell cycle progression in a pattern identical to that of BRCA1. Thus, the steady-state levels of CtIP polypeptides, which remain low in resting cells and G1 cycling cells, increase dramatically as Dividing cells traverse the G1/S boundary. CtIP can potentially modulate the functions ascribed to BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. This N-terminal domain carries a coiled-coil region and is essential for homodimerization of the protein. The C-terminal domain is family pfam08573.",".",".",".",".","."]
["ENSRNOG00000071206",13,1.093758492,2,0.128660876,8.50109624,3.087648893,0.000597684,0.000480339,"up","yes","ENSRNOG00000071206","lncRNA","chrX:68541121-68542702:-","gi|344250225|gb|EGW06329.1|",137,{"v":3e-07,"d":"3.00E-07"},"hypothetical protein I79_018985 [Cricetulus griseus]","gi|44844357|emb|AL844607.4|",92,{"v":3e-38,"d":"3.00E-38"},"Mouse DNA sequence from clone RP24-280G18 on chromosome 4, complete sequence",".",".",".",".",".",".",".",".","pfam12966","AtpR","N-ATPase, AtpR subunit. Membrane protein with three predicted transmembrane segments, two of which contain conserved Arg residues. AtpR genes are found in the N-ATPase (archaeal-type F1-Fo-ATPase) operons and are predicted to interact with the conserved Glu/Asp residues in the c subunits, regulating the assembly and/or function of the membrane-embedded ring of 'c' (proteolipid) subunits (pfam00137).",".",".",".",".","."]
["ENSRNOG00000010111",43,3.617816552,24,1.543930516,2.343250887,1.228511429,0.000607715,0.000487824,"up","yes","Exoc3l4","protein_coding","chr6:130452661-130466683:+","gi|564357330|ref|XP_006240634.1|",3424,0,"PREDICTED: exocyst complex component 3-like protein 4 isoform X2 [Rattus norvegicus]","gi|298889985|emb|FQ230530.1|",3263,0,"Rattus norvegicus TL0AEA92YE13 mRNA sequence","Q6DIA2",1217,0,"Exocyst complex component 3-like protein 4",".",".",".",".","pfam06046","Sec6","Exocyst complex component Sec6. Sec6 is a component of the multiprotein exocyst complex. Sec6 interacts with Sec8, Sec10 and Exo70.These exocyst proteins localize to regions of active exocytosis-at the growing ends of interphase cells and in the medial region of cells undergoing cytokinesis-in an F-actin-dependent and exocytosis- independent manner.","GO:0006887|exocytosis;GO:0051601|exocyst localization;","GO:0000145|exocyst;","GO:0000149|SNARE binding;",".","."]
["ENSRNOG00000065465",24,2.019246448,9,0.578973944,3.487629227,1.802246674,0.000669839,0.000533758,"up","yes","ENSRNOG00000065465","lncRNA","chr8:73863112-73865235:+",".",".",".",".","gi|260441712|gb|AC128582.3|",966,0,"Rattus norvegicus BAC CH230-349P12 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam12533","Neuro_bHLH","Neuronal helix-loop-helix transcription factor. This domain family is found in eukaryotes, and is approximately 80 amino acids in length. The family is found C-terminal to pfam00010. There is a single completely conserved residue W that may be functionally important. Neuronal basic helix-loop-helix (bHLH) transcription factors such as neuroD and neurogenin have been shown to play important roles in neuronal development.",".",".",".",".","."]
["ENSRNOG00000064228",38,3.197140209,20,1.286608764,2.484935824,1.313208593,0.000687116,0.000546799,"up","yes","ENSRNOG00000064228","protein_coding","chr12:18601158-18651608:-","gi|672072527|ref|XP_008767320.1|",963,{"v":2e-161,"d":"2.00E-161"},"PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein RGD1560262 isoform X2 [Rattus norvegicus]","gi|672033567|ref|XM_006227151.2|",1118,0,"PREDICTED: Rattus norvegicus similar to paired immunoglobin-like type 2 receptor beta (RGD1563400), transcript variant X2, mRNA","Q2YFS2",276,{"v":5e-82,"d":"5.00E-82"},"Paired immunoglobulin-like type 2 receptor beta",".",".",".",".","pfam02994","Transposase_22","L1 transposable element.",".",".",".",".","."]
["ENSRNOG00000068720",45,3.786087089,26,1.672591393,2.263605508,1.178622553,0.000689391,0.000548295,"up","yes","ENSRNOG00000068720","lncRNA","chr1:20232998-20265349:+","gi|149062621|gb|EDM13044.1|",131,{"v":5e-06,"d":"5.00E-06"},"rCG63645 [Rattus norvegicus]","gi|68532101|gb|AC153549.5|",542,0,"Mus musculus 10 BAC RP23-222O23 (Roswell Park Cancer Institute (C57BL/6J Female) Mouse BAC Library) complete sequence",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["ENSRNOG00000016716",28,2.355787522,12,0.771965258,3.051675574,1.609601596,0.00069172,0.000549666,"up","yes","Armc3","protein_coding","chr17:81832518-81917531:+","gi|559098430|ref|NP_001273949.1|",3805,0,"armadillo repeat-containing protein 3 [Rattus norvegicus]","gi|559098429|ref|NM_001287020.1|",2755,0,"Rattus norvegicus armadillo repeat containing 3 (Armc3), mRNA","A2AU72",1357,0,"Armadillo repeat-containing protein 3",".",".",".",".","pfam14381","EDR1","Ethylene-responsive protein kinase Le-CTR1. EDR1 regulates disease resistance and ethylene-induced senescence, and is also involved in stress response signalling and cell death regulation.",".",".",".","K24124","ARMC3; armadillo repeat-containing protein 3"]
["ENSRNOG00000019616",28,2.355787522,12,0.771965258,3.051675574,1.609601596,0.00069172,0.000549666,"up","yes","Prss8","protein_coding","chr1:182536229-182540815:-","gi|20301968|ref|NP_620191.1|",1571,0,"prostasin precursor [Rattus norvegicus]","gi|20301967|ref|NM_138836.1|",1898,0,"Rattus norvegicus protease, serine, 8 (Prss8), mRNA","Q9ES87",607,0,"Prostasin","VC1649",124,{"v":9e-29,"d":"9.00E-29"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0001942|hair follicle development;GO:0006508|proteolysis;GO:0009410|response to xenobiotic stimulus;GO:0010765|positive regulation of sodium ion transport;GO:0043434|response to peptide hormone;GO:0051385|response to mineralocorticoid;GO:0070633|transepithelial transport;GO:1902307|positive regulation of sodium ion transmembrane transport;","GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0019897|extrinsic component of plasma membrane;GO:0045121|membrane raft;GO:0046658|anchored component of plasma membrane;","GO:0004252|serine-type endopeptidase activity;GO:0017080|sodium channel regulator activity;","K08664","PRSS8; prostasin [EC:3.4.21.-]"]
["ENSRNOG00000070745",18,1.514434836,5,0.321652191,4.708299456,2.235206081,0.00070015,0.000555518,"up","yes","Tnf","protein_coding","chr20:3622011-3624629:+","gi|972853972|tpe|CTQ86160.1|",1292,{"v":2e-172,"d":"2.00E-172"},"TPA: tumor necrosis factor ligand 1f [Mus musculus]","gi|672085853|ref|XM_008772775.1|",1687,0,"PREDICTED: Rattus norvegicus tumor necrosis factor (LOC103694380), mRNA","P16599",450,{"v":7e-155,"d":"7.00E-155"},"Tumor necrosis factor",".",".",".",".","pfam00229","TNF","TNF(tumor Necrosis Factor) family.",".",".",".",".","."]
["ENSRNOG00000018405",21,1.766840642,7,0.450313067,3.92358288,1.972171675,0.000722451,0.000572472,"up","yes","Apoc4","protein_coding","chr1:79335745-79339981:-","gi|157821489|ref|NP_001102889.1|",652,{"v":1E-84,"d":"1.00E-84"},"apolipoprotein C-IV precursor [Rattus norvegicus]","gi|298896558|emb|FQ218092.1|",506,0,"Rattus norvegicus TL0ABA9YJ02 mRNA sequence","P55797",255,{"v":3e-86,"d":"3.00E-86"},"Apolipoprotein C-IV",".",".",".",".","pfam15119","APOC4","Apolipoprotein C4.","GO:0006869|lipid transport;GO:0008150|biological_process;GO:0010890|positive regulation of sequestering of triglyceride;GO:0070328|triglyceride homeostasis;","GO:0005575|cellular_component;GO:0034361|very-low-density lipoprotein particle;GO:0034364|high-density lipoprotein particle;","GO:0003674|molecular_function;","K25362","APOC4; apolipoprotein C-IV"]
["ENSRNOG00000017625",56,4.711575044,36,2.315895775,2.034450382,1.024639095,0.00072409,0.000573296,"up","yes","Htr2b","protein_coding","chr9:86742102-86755108:-","gi|672065531|ref|XP_008765438.1|",2400,0,"PREDICTED: 5-hydroxytryptamine receptor 2B isoform X1 [Rattus norvegicus]","gi|672065530|ref|XM_008767216.1|",1971,0,"PREDICTED: Rattus norvegicus 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled (Htr2b), transcript variant X1, mRNA","P30994",922,0,"5-hydroxytryptamine receptor 2B",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001755|neural crest cell migration;GO:0001819|positive regulation of cytokine production;GO:0001938|positive regulation of endothelial cell proliferation;GO:0002031|G protein-coupled receptor internalization;GO:0003007|heart morphogenesis;GO:0003300|cardiac muscle hypertrophy;GO:0006874|cellular calcium ion homeostasis;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007187|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007202|activation of phospholipase C activity;GO:0007205|protein kinase C-activating G protein-coupled receptor signaling pathway;GO:0007208|phospholipase C-activating serotonin receptor signaling pathway;GO:0007268|chemical synaptic transmission;GO:0007507|heart development;GO:0008284|positive regulation of cell proliferation;GO:0009410|response to xenobiotic stimulus;GO:0010507|negative regulation of autophagy;GO:0010513|positive regulation of phosphatidylinositol biosynthetic process;GO:0014033|neural crest cell differentiation;GO:0014065|phosphatidylinositol 3-kinase signaling;GO:0014827|intestine smooth muscle contraction;GO:0016310|phosphorylation;GO:0019722|calcium-mediated signaling;GO:0019934|cGMP-mediated signaling;GO:0034220|ion transmembrane transport;GO:0035733|hepatic stellate cell activation;GO:0042310|vasoconstriction;GO:0043066|negative regulation of apoptotic process;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043406|positive regulation of MAP kinase activity;GO:0043647|inositol phosphate metabolic process;GO:0048598|embryonic morphogenesis;GO:0050795|regulation of behavior;GO:0051000|positive regulation of nitric-oxide synthase activity;GO:0051209|release of sequestered calcium ion into cytosol;GO:0051781|positive regulation of cell division;GO:0060548|negative regulation of cell death;GO:0070371|ERK1 and ERK2 cascade;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070528|protein kinase C signaling;GO:0071418|cellular response to amine stimulus;GO:0071502|cellular response to temperature stimulus;GO:0098664|G protein-coupled serotonin receptor signaling pathway;GO:1904015|cellular response to serotonin;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0030425|dendrite;GO:0043025|neuronal cell body;GO:0045202|synapse;GO:0098666|G protein-coupled serotonin receptor complex;","GO:0001587|Gq/11-coupled serotonin receptor activity;GO:0001965|G-protein alpha-subunit binding;GO:0004993|G protein-coupled serotonin receptor activity;GO:0005096|GTPase activator activity;GO:0005515|protein binding;GO:0030594|neurotransmitter receptor activity;GO:0051378|serotonin binding;","K04157","HTR2; 5-hydroxytryptamine receptor 2"]
["ENSRNOG00000019920",39,3.281275477,21,1.350939202,2.42888464,1.280293971,0.000746172,0.000589066,"up","yes","Doc2a","protein_coding","chr1:181458390-181462030:+","gi|12621100|ref|NP_075226.1|",1542,0,"double C2-like domain-containing protein alpha [Rattus norvegicus]","gi|672038566|ref|XM_006230337.2|",1447,0,"PREDICTED: Rattus norvegicus double C2-like domains, alpha (Doc2a), transcript variant X2, mRNA","P70611",598,0,"Double C2-like domain-containing protein alpha","YOR086c",56.2,{"v":2e-07,"d":"2.00E-07"},"COG5038","pfam00168","C2","C2 domain.","GO:0016079|synaptic vesicle exocytosis;GO:0017158|regulation of calcium ion-dependent exocytosis;GO:0061669|spontaneous neurotransmitter secretion;","GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005764|lysosome;GO:0030054|cell junction;GO:0043005|neuron projection;GO:0098850|extrinsic component of synaptic vesicle membrane;","GO:0005509|calcium ion binding;GO:0005544|calcium-dependent phospholipid binding;","K19916","DOC2A; double C2-like domain-containing protein alpha"]
["ENSRNOG00000009030",48,4.038492895,29,1.865582707,2.164735382,1.11419068,0.000806204,0.00063352,"up","yes","Rab19","protein_coding","chr4:68156881-68166886:+","gi|66730270|ref|NP_001019497.1|",1142,{"v":9e-152,"d":"9.00E-152"},"ras-related protein Rab-19 [Rattus norvegicus]","gi|66730269|ref|NM_001024326.1|",1336,0,"Rattus norvegicus RAB19, member RAS oncogene family (Rab19), mRNA","Q5M7U5",444,{"v":3E-153,"d":"3.00E-153"},"Ras-related protein Rab-19",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0000045|autophagosome assembly;GO:0006886|intracellular protein transport;","GO:0005886|plasma membrane;GO:0012505|endomembrane system;","GO:0003924|GTPase activity;GO:0005525|GTP binding;","K17047","RAB19; Ras-related protein Rab-19"]
["ENSRNOG00000066130",48,4.038492895,29,1.865582707,2.164735382,1.11419068,0.000806204,0.00063352,"up","yes","ENSRNOG00000066130","lncRNA","chr7:9951428-9953419:+","gi|537218706|gb|ERE82209.1|",160,{"v":2E-8,"d":"2.00E-08"},"Retroviral nucleocapsid protein Gag containing protein [Cricetulus griseus]","gi|88608890|gb|AC131405.5|",1218,0,"Rattus norvegicus BAC CH230-179I7 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam00607","Gag_p24","gag gene protein p24 (core nucleocapsid protein). p24 forms inner protein layer of the nucleocapsid. ELISA tests for p24 is the most commonly used method to demonstrate virus replication both in vivo and in vitro.",".",".",".",".","."]
["ENSRNOG00000018266",34,2.860599134,17,1.093617449,2.61572192,1.387209175,0.000811737,0.000637591,"up","yes","Slc23a3","protein_coding","chr9:76622800-76631366:-","gi|157823783|ref|NP_001102476.1|",2487,0,"solute carrier family 23 member 3 [Rattus norvegicus]","gi|157823782|ref|NM_001109006.1|",2052,0,"Rattus norvegicus solute carrier family 23, member 3 (Slc23a3), mRNA","Q60850",875,0,"Solute carrier family 23 member 3","BS_yunK",52.4,{"v":3e-06,"d":"3.00E-06"},"COG2233","pfam00860","Xan_ur_permease","Permease family. This family includes permeases for diverse substrates such as xanthine, uracil, and vitamin C. However many members of this family are functionally uncharacterized and may transport other substrates. Members of this family have ten predicted transmembrane helices.","GO:0055085|transmembrane transport;","GO:0016021|integral component of membrane;","GO:0005215|transporter activity;GO:0022857|transmembrane transporter activity;","K14612","SLC23A3, SVCT3; solute carrier family 23 (nucleobase transporter), member 3"]
["ENSRNOG00000022426",25,2.103381716,10,0.643304382,3.2696524,1.70913727,0.000819952,0.000643487,"up","yes","ENSRNOG00000022426","protein_coding","chr12:15229743-15242139:-","gi|564315040|ref|XP_006221342.1|",1571,0,"PREDICTED: uncharacterized protein LOC102546864 [Rattus norvegicus]","gi|672026549|ref|XM_008759032.1|",1675,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102546864 (LOC102546864), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam02628","COX15-CtaA","Cytochrome oxidase assembly protein. This is a family of integral membrane proteins. CtaA is required for cytochrome aa3 oxidase assembly in Bacillus subtilis. COX15 is required for cytochrome c oxidase assembly in yeast.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000046803",25,2.103381716,10,0.643304382,3.2696524,1.70913727,0.000819952,0.000643487,"up","yes","Arhgef16","protein_coding","chr5:164844161-164866212:-","gi|189027103|ref|NP_001121063.1|",3471,0,"rho guanine nucleotide exchange factor 16 [Rattus norvegicus]","gi|189027102|ref|NM_001127591.1|",2729,0,"Rattus norvegicus Rho guanine nucleotide exchange factor 16 (Arhgef16), mRNA","Q3U5C8",1235,0,"Rho guanine nucleotide exchange factor 16","SPCC645.07",91.7,{"v":7e-18,"d":"7.00E-18"},"COG5422","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0060326|cell chemotaxis;GO:0090630|activation of GTPase activity;GO:1903078|positive regulation of protein localization to plasma membrane;",".","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0030165|PDZ domain binding;GO:0030971|receptor tyrosine kinase binding;GO:0031267|small GTPase binding;","K20688","ARHGEF16; Rho guanine nucleotide exchange factor 16"]
["ENSRNOG00000062835",49,4.122628164,30,1.929913146,2.136172901,1.095028423,0.000843163,0.00066037,"up","yes","ENSRNOG00000062835","protein_coding","chr5:60256314-60276810:-","gi|37361874|gb|AAQ91050.1|",282,{"v":1e-24,"d":"1.00E-24"},"LRRGT00094 [Rattus norvegicus]","gi|401461827|gb|AC246663.5|",855,0,"Rattus norvegicus Y Chr BAC RNECO-121H12 (Amplicon Express Rat SHR-Akr (EcoR1 Digest) BAC library) complete sequence","P31789",91.3,{"v":6e-18,"d":"6.00E-18"},"Envelope glycoprotein",".",".",".",".","pfam01500","Keratin_B2","Keratin, high sulfur B2 protein. High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.",".",".",".",".","."]
["ENSRNOG00000011042",16,1.346164298,4,0.257321753,5.23144384,2.387209175,0.000886523,0.000690852,"up","yes","ENSRNOG00000011042","protein_coding","chr9:98591228-98690913:-","gi|149037416|gb|EDL91847.1|",1813,0,"rCG55704, isoform CRA_a [Rattus norvegicus]","gi|672024344|ref|XR_349259.2|",1236,0,"PREDICTED: Rattus norvegicus similar to 2610034M16Rik protein (RGD1560925), misc_RNA","Q7TQG1",63.5,{"v":2e-09,"d":"2.00E-09"},"Pleckstrin homology domain-containing family A member 6",".",".",".",".","pfam00169","PH","PH domain. PH stands for pleckstrin homology.",".",".",".",".","."]
["ENSRNOG00000004752",30,2.524058059,14,0.900626135,2.8025592,1.486744848,0.000920808,0.000714603,"up","yes","Nalcn","protein_coding","chr15:100398615-100741001:-","gi|755548470|ref|XP_011243398.1|",8774,0,"PREDICTED: sodium leak channel non-selective protein isoform X4 [Mus musculus]","gi|24025649|ref|NM_153630.1|",6737,0,"Rattus norvegicus sodium leak channel, non-selective (Nalcn), mRNA","Q6Q760",3348,0,"Sodium leak channel non-selective protein",".",".",".",".","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0008150|biological_process;GO:0034765|regulation of ion transmembrane transport;GO:0035725|sodium ion transmembrane transport;GO:0060075|regulation of resting membrane potential;GO:0070588|calcium ion transmembrane transport;GO:0071805|potassium ion transmembrane transport;GO:0098655|cation transmembrane transport;","GO:0005575|cellular_component;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0005244|voltage-gated ion channel activity;GO:0005261|cation channel activity;GO:0005272|sodium channel activity;GO:0022840|leak channel activity;","K21863","NALCN; sodium leak channel non-selective protein"]
["ENSRNOG00000012215",30,2.524058059,14,0.900626135,2.8025592,1.486744848,0.000920808,0.000714603,"up","yes","Baiap2l2","protein_coding","chr7:110824375-110850702:-","gi|403420586|ref|NP_001258149.1|",2275,0,"brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 [Rattus norvegicus]","gi|403420585|ref|NM_001271220.1|",2079,0,"Rattus norvegicus BAI1-associated protein 2-like 2 (Baiap2l2), mRNA","Q80Y61",868,0,"Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2",".",".",".",".","pfam08397","IMD","IRSp53/MIM homology domain. The N-terminal predicted helical stretch of the insulin receptor tyrosine kinase substrate p53 (IRSp53) is an evolutionary conserved F-actin bundling domain involved in filopodium formation. The domain has been named IMD after the IRSp53 and missing in metastasis (MIM) proteins in which it occurs. Filopodium-inducing IMD activity is regulated by Cdc42 and Rac1 and is SH3-independent.","GO:0007009|plasma membrane organization;GO:0030838|positive regulation of actin filament polymerization;GO:0051017|actin filament bundle assembly;GO:0051764|actin crosslink formation;GO:0061024|membrane organization;GO:2000251|positive regulation of actin cytoskeleton reorganization;","GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0012506|vesicle membrane;GO:0044291|cell-cell contact zone;GO:0071439|clathrin complex;","GO:0005543|phospholipid binding;GO:0042802|identical protein binding;","K23645","BAIAP2L2; BAI1-associated protein 2-like protein 2"]
["ENSRNOG00000053624",30,2.524058059,14,0.900626135,2.8025592,1.486744848,0.000920808,0.000714603,"up","yes","AABR07058017.2","lncRNA","chr7:90386604-90406762:-","gi|672033662|ref|XP_008756507.1|",381,{"v":1E-41,"d":"1.00E-41"},"PREDICTED: uncharacterized protein LOC103690725 isoform X3 [Rattus norvegicus]","gi|672033663|ref|XM_008758286.1|",277,{"v":2e-141,"d":"2.00E-141"},"PREDICTED: Rattus norvegicus uncharacterized LOC103690725 (LOC103690725), transcript variant X4, mRNA",".",".",".",".",".",".",".",".","pfam06182","ABC2_membrane_6","ABC-2 family transporter protein. This family acts as the transmembrane domain (TMD) of ABC transporters. The family includes proteins responsible for the transport of herbicides.",".",".",".",".","."]
["ENSRNOG00000031168",52,4.37503397,33,2.12290446,2.060871816,1.043254774,0.000946962,0.000733959,"up","yes","Arhgap15","protein_coding","chr3:27989633-28600265:+","gi|62078565|ref|NP_001013939.1|",2173,0,"rho GTPase-activating protein 15 [Rattus norvegicus]","gi|62078564|ref|NM_001013917.1|",1306,0,"Rattus norvegicus Rho GTPase activating protein 15 (Arhgap15), mRNA","Q6AYC5",841,0,"Rho GTPase-activating protein 15",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0007165|signal transduction;GO:0008360|regulation of cell shape;GO:0043087|regulation of GTPase activity;","GO:0005737|cytoplasm;GO:0016020|membrane;","GO:0005096|GTPase activator activity;","K20637","ARHGAP15; Rho GTPase-activating protein 15"]
["ENSRNOG00000013887",26,2.187516985,11,0.70763482,3.091307724,1.628217274,9.78687E-4,0.000756394,"up","yes","Adra2b","protein_coding","chr3:114585169-114589355:+","gi|304434812|ref|NP_612514.2|",2120,0,"alpha-2B adrenergic receptor [Rattus norvegicus]","gi|304434811|ref|NM_138505.2|",4047,0,"Rattus norvegicus adrenoceptor alpha 2B (Adra2b), mRNA","P19328",798,0,"Alpha-2B adrenergic receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0000165|MAPK cascade;GO:0001525|angiogenesis;GO:0003056|regulation of vascular smooth muscle contraction;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007565|female pregnancy;GO:0030168|platelet activation;GO:0032148|activation of protein kinase B activity;GO:0035624|receptor transactivation;GO:0043410|positive regulation of MAPK cascade;GO:0045666|positive regulation of neuron differentiation;GO:0045777|positive regulation of blood pressure;GO:0070474|positive regulation of uterine smooth muscle contraction;GO:0071875|adrenergic receptor signaling pathway;GO:0071880|adenylate cyclase-activating adrenergic receptor signaling pathway;","GO:0005829|cytosol;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0004930|G protein-coupled receptor activity;GO:0004935|adrenergic receptor activity;GO:0004938|alpha2-adrenergic receptor activity;GO:0005515|protein binding;GO:0051379|epinephrine binding;","K04139","ADRA2B; adrenergic receptor alpha-2B"]
["ENSRNOG00000010248",36,3.028869671,19,1.222278326,2.478052345,1.309206663,9.7952E-4,7.56823E-4,"up","yes","Serpini1","protein_coding","chr2:160346758-160433135:+","gi|16758618|ref|NP_446231.1|",2102,0,"neuroserpin precursor [Rattus norvegicus]","gi|16758617|ref|NM_053779.1|",2886,0,"Rattus norvegicus serpin peptidase inhibitor, clade I (neuroserpin), member 1 (Serpini1), mRNA","Q9JLD2",814,0,"Neuroserpin","all0778",184,{"v":5e-50,"d":"5.00E-50"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0010951|negative regulation of endopeptidase activity;GO:0010976|positive regulation of neuron projection development;GO:0030155|regulation of cell adhesion;","GO:0005615|extracellular space;GO:0034774|secretory granule lumen;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0060205|cytoplasmic vesicle lumen;","GO:0004867|serine-type endopeptidase inhibitor activity;","K23412","SERPINI1; neuroserpin"]
["ENSRNOG00000011263",36,3.028869671,19,1.222278326,2.478052345,1.309206663,9.7952E-4,7.56823E-4,"up","yes","Plac9","protein_coding","chr16:1459456-1474399:-","gi|564387936|ref|XP_006252692.1|",256,{"v":2e-23,"d":"2.00E-23"},"PREDICTED: placenta-specific protein 9 isoform X1 [Rattus norvegicus]","gi|672079314|ref|XM_006252630.2|",344,{"v":1e-178,"d":"1.00E-178"},"PREDICTED: Rattus norvegicus placenta-specific 9 (Plac9), transcript variant X1, mRNA","Q8K262",77.8,{"v":1e-16,"d":"1.00E-16"},"Placenta-specific protein 9",".",".",".",".","pfam15205","PLAC9","Placenta-specific protein 9. This family of proteins was identified as being enriched in placenta.",".",".",".",".","."]
["ENSRNOG00000016044",31,2.608193328,15,0.964956573,2.702912651,1.43451489,0.001039331,0.000799293,"up","yes","Mab21l3","protein_coding","chr2:189248895-189271652:-","gi|157824039|ref|NP_001099926.1|",2285,0,"protein mab-21-like 3 [Rattus norvegicus]","gi|157824038|ref|NM_001106456.1|",3926,0,"Rattus norvegicus mab-21-like 3 (C. elegans) (Mab21l3), mRNA",".",".",".",".",".",".",".",".","pfam03281","Mab-21","Mab-21 protein. This family contains Mab-21 and Mab-21 like proteins. In C. elegans these proteins are required for several aspects of embryonic development.",".",".",".",".","."]
["ENSRNOG00000020244",31,2.608193328,15,0.964956573,2.702912651,1.43451489,0.001039331,0.000799293,"up","yes","Perm1","protein_coding","chr5:166800030-166805323:+","gi|157819345|ref|NP_001101471.1|",3556,0,"PPARGC1 and ESRR induced regulator, muscle 1 [Rattus norvegicus]","gi|157819344|ref|NM_001108001.1|",3861,0,"Rattus norvegicus PPARGC1 and ESRR induced regulator, muscle 1 (Perm1), mRNA","Q149B8",1092,0,"PGC-1 and ERR-induced regulator in muscle protein 1",".",".",".",".","pfam05109","Herpes_BLLF1","Herpes virus major outer envelope glycoprotein (BLLF1). This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralizing antibodies in vivo.","GO:0006355|regulation of transcription, DNA-templated;GO:0014850|response to muscle activity;","GO:0005634|nucleus;GO:0005737|cytoplasm;",".",".","."]
["ENSRNOG00000066596",37,3.11300494,20,1.286608764,2.419542776,1.274734445,1.062934E-3,0.000815487,"up","yes","ENSRNOG00000066596","lncRNA","chr16:18332870-18333956:+",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","pfam14800","DUF4481","Domain of unknown function (DUF4481).",".",".",".",".","."]
["ENSRNOG00000053804",14,1.177893761,3,0.192991315,6.103351147,2.609601596,0.00107265,0.000822131,"up","yes","Prmt8","protein_coding","chr4:160535813-160617930:-","gi|357527369|ref|NP_958759.2|",1886,0,"protein arginine N-methyltransferase 8 [Mus musculus]","gi|357527368|ref|NM_201371.2|",2080,0,"Mus musculus protein arginine N-methyltransferase 8 (Prmt8), mRNA","Q6PAK3",731,0,"Protein arginine N-methyltransferase 8",".",".",".",".","pfam12847","Methyltransf_18","Methyltransferase domain. Protein in this family function as methyltransferases.","GO:0006479|protein methylation;GO:0008150|biological_process;GO:0016571|histone methylation;GO:0018216|peptidyl-arginine methylation;GO:0019919|peptidyl-arginine methylation, to asymmetrical-dimethyl arginine;GO:0034969|histone arginine methylation;GO:0051260|protein homooligomerization;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0098753|anchored component of the cytoplasmic side of the plasma membrane;","GO:0003674|molecular_function;GO:0008469|histone-arginine N-methyltransferase activity;GO:0008757|S-adenosylmethionine-dependent methyltransferase activity;GO:0019899|enzyme binding;GO:0035241|protein-arginine omega-N monomethyltransferase activity;GO:0035242|protein-arginine omega-N asymmetric methyltransferase activity;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:1904047|S-adenosyl-L-methionine binding;","K11439","PRMT8; type I protein arginine methyltransferase [EC:2.1.1.319]"]
["ENSRNOG00000061883",14,1.177893761,3,0.192991315,6.103351147,2.609601596,0.00107265,0.000822131,"up","yes","Aqp9","protein_coding","chr8:71797234-71837395:-","gi|12621144|ref|NP_075249.1|",1532,0,"aquaporin-9 [Rattus norvegicus]","gi|55742829|ref|NM_022960.2|",1715,0,"Rattus norvegicus aquaporin 9 (Aqp9), mRNA","P56627",594,0,"Aquaporin-9","PA3581",163,{"v":9e-45,"d":"9.00E-45"},"COG0580","pfam00230","MIP","Major intrinsic protein. MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.","GO:0006833|water transport;GO:0006863|purine nucleobase transport;GO:0010033|response to organic substance;GO:0015722|canalicular bile acid transport;GO:0015791|polyol transport;GO:0015793|glycerol transport;GO:0015837|amine transport;GO:0015855|pyrimidine nucleobase transport;GO:0046689|response to mercury ion;GO:0071320|cellular response to cAMP;GO:0071918|urea transmembrane transport;GO:0072531|pyrimidine-containing compound transmembrane transport;GO:1904823|purine nucleobase transmembrane transport;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016323|basolateral plasma membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0005345|purine nucleobase transmembrane transporter activity;GO:0005350|pyrimidine nucleobase transmembrane transporter activity;GO:0005515|protein binding;GO:0015204|urea transmembrane transporter activity;GO:0015250|water channel activity;GO:0015254|glycerol channel activity;GO:0015265|urea channel activity;","K09877","AQP9; aquaporin-9"]
["ENSRNOG00000016593",9,0.757217418,0,0.032165219,23.54149728,4.557134176,1.083887E-3,0.000829808,"up","yes","Pde6c","protein_coding","chr1:235909775-235965315:+","gi|564333599|ref|XP_006231391.1|",4586,0,"PREDICTED: cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform X2 [Rattus norvegicus]","gi|672040241|ref|XM_006231329.2|",2667,0,"PREDICTED: Rattus norvegicus phosphodiesterase 6C, cGMP specific, cone, alpha prime (Pde6c), transcript variant X2, mRNA","Q91ZQ1",1675,0,"Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'",".",".",".",".","pfam00233","PDEase_I","3'5'-cyclic nucleotide phosphodiesterase.","GO:0007165|signal transduction;GO:0007601|visual perception;GO:0007603|phototransduction, visible light;GO:0008150|biological_process;GO:0046549|retinal cone cell development;GO:0050953|sensory perception of light stimulus;","GO:0005575|cellular_component;","GO:0003674|molecular_function;GO:0004114|3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0046872|metal ion binding;","K13757","PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [EC:3.1.4.35]"]
["ENSRNOG00000019044",9,0.757217418,0,0.032165219,23.54149728,4.557134176,1.083887E-3,0.000829808,"up","yes","Adam30","protein_coding","chr2:185752072-185755599:+","gi|157819331|ref|NP_001103070.1|",3620,0,"disintegrin and metalloproteinase domain-containing protein 30 precursor [Rattus norvegicus]","gi|157819330|ref|NM_001109600.1|",3417,0,"Rattus norvegicus ADAM metallopeptidase domain 30 (Adam30), mRNA","Q9UKF2",850,0,"Disintegrin and metalloproteinase domain-containing protein 30",".",".",".",".","pfam08516","ADAM_CR","ADAM cysteine-rich. ADAMs are membrane-anchored proteases that proteolytically modify cell surface and extracellular matrix (ECM) in order to alter cell behaviour. It has been shown that the cysteine-rich domain of ADAM13 regulates the protein's metalloprotease activity.","GO:0006508|proteolysis;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:1990913|sperm head plasma membrane;","GO:0004222|metalloendopeptidase activity;","K08615","ADAM30; disintegrin and metalloproteinase domain-containing protein 30 [EC:3.4.24.-]"]
["ENSRNOG00000020337",9,0.757217418,0,0.032165219,23.54149728,4.557134176,1.083887E-3,0.000829808,"up","yes","Sla2","protein_coding","chr3:145368598-145382480:-","gi|287323377|ref|NP_001165589.1|",1110,{"v":2e-146,"d":"2.00E-146"},"src-like-adapter 2 [Rattus norvegicus]","gi|672047615|ref|XM_008762374.1|",1107,0,"PREDICTED: Rattus norvegicus Src-like-adaptor 2 (Sla2), transcript variant X1, mRNA","Q8R4L0",398,{"v":6e-135,"d":"6.00E-135"},"Src-like-adapter 2",".",".",".",".","pfam00017","SH2","SH2 domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0042110|T cell activation;GO:0043551|regulation of phosphatidylinositol 3-kinase activity;GO:0046854|phosphatidylinositol phosphorylation;GO:0050849|negative regulation of calcium-mediated signaling;GO:0050860|negative regulation of T cell receptor signaling pathway;","GO:0005654|nucleoplasm;GO:0005770|late endosome;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005942|phosphatidylinositol 3-kinase complex;GO:0031410|cytoplasmic vesicle;GO:0043231|intracellular membrane-bounded organelle;","GO:0035591|signaling adaptor activity;GO:0046935|1-phosphatidylinositol-3-kinase regulator activity;GO:0047485|protein N-terminus binding;","K23698","SLA; src-like-adapter"]
["ENSRNOG00000030332",9,0.757217418,0,0.032165219,23.54149728,4.557134176,1.083887E-3,0.000829808,"up","yes","Ighg1","protein_coding","chr6:132389370-132393397:-","gi|56971338|gb|AAH88271.1|",1648,0,"Immunoglobulin heavy chain (gamma polypeptide) [Rattus norvegicus]","gi|62205065|gb|BC092584.1|",1089,0,"Rattus norvegicus Immunoglobulin heavy chain (gamma polypeptide), mRNA (cDNA clone MGC:108947 IMAGE:7384581), complete cds","P20759",636,0,"Ig gamma-1 chain C region",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.",".",".",".",".","."]
["ENSRNOG00000012843",46,3.870222358,28,1.801252269,2.14862872,1.103416209,0.001136086,8.66846E-4,"up","yes","Aspg","protein_coding","chr6:131176874-131196268:+","gi|71051323|gb|AAH98655.1|",2723,0,"Asparaginase homolog (S. cerevisiae) [Rattus norvegicus]","gi|402744576|ref|NM_144750.2|",2509,0,"Rattus norvegicus asparaginase (Aspg), mRNA","O88202",1053,0,"60 kDa lysophospholipase","YPO2161",280,{"v":3e-85,"d":"3.00E-85"},"COG0252","pfam00710","Asparaginase","Asparaginase.","GO:0006520|cellular amino acid metabolic process;GO:0006528|asparagine metabolic process;GO:0006644|phospholipid metabolic process;GO:0016042|lipid catabolic process;",".","GO:0003847|1-alkyl-2-acetylglycerophosphocholine esterase activity;GO:0004067|asparaginase activity;GO:0004622|lysophospholipase activity;GO:0016747|transferase activity, transferring acyl groups other than amino-acyl groups;GO:0102545|phosphatidyl phospholipase B activity;","K13278","ASPG; 60kDa lysophospholipase [EC:3.1.1.5 3.1.1.47 3.5.1.1]"]
["ENSRNOG00000065970",23,1.935111179,9,0.578973944,3.342311342,1.740846129,0.001150116,0.000876323,"up","yes","Klrc3","protein_coding","chr4:163106024-163112336:-","gi|71361671|ref|NP_001025079.1|",1234,{"v":6e-166,"d":"6.00E-166"},"killer cell lectin-like receptor subfamily C, member 3 [Rattus norvegicus]","gi|672051215|ref|XR_592292.1|",1518,0,"PREDICTED: Rattus norvegicus killer cell lectin-like receptor subfamily C, member 3 (Klrc3), transcript variant X1, misc_RNA","Q9MZJ3",166,{"v":4e-46,"d":"4.00E-46"},"NKG2-A/NKG2-B type II integral membrane protein",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type",".",".",".",".","."]
["ENSRNOG00000069169",23,1.935111179,9,0.578973944,3.342311342,1.740846129,0.001150116,0.000876323,"up","yes","ENSRNOG00000069169","protein_coding","chr11:76854210-76854323:-",".",".",".",".","gi|387911232|emb|FO117627.14|",114,{"v":1E-51,"d":"1.00E-51"},"Rat DNA sequence from clone bRB-356K3, complete sequence",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["ENSRNOG00000028721",10,0.841352686,1,0.064330438,13.0786096,3.70913727,1.164736E-3,0.000886842,"up","yes","Otor","protein_coding","chr3:130415339-130418601:+","gi|157822605|ref|NP_001102430.1|",619,{"v":2e-77,"d":"2.00E-77"},"otoraplin precursor [Rattus norvegicus]","gi|157822604|ref|NM_001108960.1|",906,0,"Rattus norvegicus otoraplin (Otor), mRNA","Q9JIE3",229,{"v":1E-73,"d":"1.00E-73"},"Otoraplin",".",".",".",".","pfam07653","SH3_2","Variant SH3 domain. SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta barrel.","GO:0001502|cartilage condensation;",".",".","K25714","OTOR; otoraplin"]
["ENSRNOG00000048771",10,0.841352686,1,0.064330438,13.0786096,3.70913727,1.164736E-3,0.000886842,"up","yes","RGD1559482","protein_coding","chr10:100136867-100140427:+","gi|293340561|ref|XP_001081656.2|",1068,{"v":3e-144,"d":"3.00E-144"},"PREDICTED: CMRF35-like molecule isoform X1 [Rattus norvegicus]","gi|672070031|ref|XM_577143.5|",869,0,"PREDICTED: Rattus norvegicus similar to leukocyte mono-Ig-like receptor2 (RGD1562667), transcript variant X1, mRNA","Q7TSN2",271,{"v":8e-89,"d":"8.00E-89"},"CMRF35-like molecule",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004888|transmembrane signaling receptor activity;","K06719","CD300; CD300 antigen"]
["ENSRNOG00000062755",10,0.841352686,1,0.064330438,13.0786096,3.70913727,1.164736E-3,0.000886842,"up","yes","ENSRNOG00000062755","lncRNA","chr15:46332238-46346270:+","gi|149049923|gb|EDM02247.1|",412,{"v":2E-45,"d":"2.00E-45"},"rCG36927 [Rattus norvegicus]","gi|672078631|ref|XR_596191.1|",1221,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103693702 (LOC103693702), transcript variant X3, ncRNA",".",".",".",".",".",".",".",".","pfam06699","PIG-F","GPI biosynthesis protein family Pig-F. PIG-F is involved in glycosylphosphatidylinositol (GPI) anchor biosynthesis.",".",".",".",".","."]
["ENSRNOG00000048874",12,1.009623224,2,0.128660876,7.84716576,2.972171675,0.001200257,0.000911848,"up","yes","Gckr","protein_coding","chr6:25045100-25075654:-","gi|6978884|ref|NP_037252.1|",3194,0,"glucokinase regulatory protein [Rattus norvegicus]","gi|52138600|ref|NM_013120.2|",2269,0,"Rattus norvegicus glucokinase (hexokinase 4) regulator (Gckr), mRNA","Q07071",1236,0,"Glucokinase regulatory protein","VC0690",54.3,{"v":5e-07,"d":"5.00E-07"},"COG2103","pfam15521","Toxin_41","Putative toxin 41. A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin contains two structural domains, an N-terminal alpha/beta domain and a C-terminal all-beta domain. The domain contains conserved GxR, RxxxoH GxE and GxxH motifs and a conserved histidine residue. In bacterial polymorphic toxin systems, the toxin is usually exported by the Photorhabdus virulence cassette (PVC)-type export system.","GO:0001678|cellular glucose homeostasis;GO:0006006|glucose metabolic process;GO:0006606|protein import into nucleus;GO:0009750|response to fructose;GO:0033132|negative regulation of glucokinase activity;GO:0033133|positive regulation of glucokinase activity;GO:0034504|protein localization to nucleus;GO:0042593|glucose homeostasis;GO:0046415|urate metabolic process;GO:0051594|detection of glucose;GO:0070328|triglyceride homeostasis;GO:1901135|carbohydrate derivative metabolic process;GO:1903300|negative regulation of hexokinase activity;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;","GO:0004857|enzyme inhibitor activity;GO:0005515|protein binding;GO:0019899|enzyme binding;GO:0019904|protein domain specific binding;GO:0030246|carbohydrate binding;GO:0070095|fructose-6-phosphate binding;",".","."]
["ENSRNOG00000050990",12,1.009623224,2,0.128660876,7.84716576,2.972171675,0.001200257,0.000911848,"up","yes","Glyatl3","protein_coding","chr9:19977302-19995650:+","gi|222831640|ref|NP_001138534.1|",1566,0,"glycine N-acyltransferase-like protein 3 [Rattus norvegicus]","gi|755557035|ref|XM_006524587.2|",992,0,"PREDICTED: Mus musculus glycine-N-acyltransferase-like 3 (Glyatl3), transcript variant X1, mRNA","Q5SZD4",523,0,"Glycine N-acyltransferase-like protein 3",".",".",".",".","pfam06021","Gly_acyl_tr_N","Aralkyl acyl-CoA:amino acid N-acyltransferase. This family consists of several mammalian specific aralkyl acyl-CoA:amino acid N-acyltransferase (glycine N-acyltransferase) proteins EC:2.3.1.13.",".","GO:0005739|mitochondrion;","GO:0016410|N-acyltransferase activity;GO:0047961|glycine N-acyltransferase activity;","K22750","GLYATL3; glycine N-acyltransferase-like protein 3 [EC:2.3.1.-]"]
["ENSRNOG00000061101",12,1.009623224,2,0.128660876,7.84716576,2.972171675,0.001200257,0.000911848,"up","yes","Ripply1","protein_coding","chrX:103436729-103443349:-","gi|672017390|ref|XP_008773739.1|",503,{"v":2E-55,"d":"2.00E-55"},"PREDICTED: protein ripply1-like [Rattus norvegicus]","gi|672017389|ref|XM_008775517.1|",1131,0,"PREDICTED: Rattus norvegicus protein ripply1-like (LOC103690346), mRNA","Q2WG77",146,{"v":2e-38,"d":"2.00E-38"},"Protein ripply1",".",".",".",".","pfam14998","Ripply","Transcription Regulator. The precise function of this family is not clear, but it is thought to play a role in somitogenesis, development and transcriptional repression. Ripply is also known by an alternative name, Bowline. Bowline, is an associate protein of the transcriptional co-repressor XGrg-4. This family contains two conserved sequence motifs: WRPW and FPVQATI. The WRPW motif is thought to be required for binding to tle/groucho proteins. Ripply3 is also known as Down Syndrome Critical Region Protein 6 homolog. This family of proteins is found in eukaryotes. Proteins in this family are typically between 109 and 154 amino acids in length.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0007219|Notch signaling pathway;GO:0009880|embryonic pattern specification;GO:0010468|regulation of gene expression;GO:0032525|somite rostral/caudal axis specification;GO:0060349|bone morphogenesis;","GO:0005634|nucleus;",".",".","."]
["ENSRNOG00000063517",12,1.009623224,2,0.128660876,7.84716576,2.972171675,0.001200257,0.000911848,"up","yes","Rflna","protein_coding","chr12:31633361-31642317:-","gi|157817883|ref|NP_001103017.1|",801,{"v":1E-100,"d":"1.00E-100"},"family with sequence similarity 101, member A [Rattus norvegicus]","gi|157817882|ref|NM_001109547.1|",1556,0,"Rattus norvegicus family with sequence similarity 101, member A (Fam101a), mRNA","Q7TS73",291,{"v":7E-94,"d":"7.00E-94"},"Refilin-A",".",".",".",".","pfam15068","FAM101","FAM101 family. This protein family includes the actin regulators, Refilin A and B, however the exact function of this protein family remains unknown. Refilin is thought to stabilize peri-nuclear actin filament bundles, important in fibroblasts. Refilin is important as changes in localisation and shape in the nucleus plays a role in cellular and developmental processes.",".",".",".",".","."]
["ENSRNOG00000067363",12,1.009623224,2,0.128660876,7.84716576,2.972171675,0.001200257,0.000911848,"up","yes","Xkrx","protein_coding","chrX:97341152-97354759:-","gi|58866038|ref|NP_001012230.1|",2200,0,"XK-related protein 2 [Rattus norvegicus]","gi|58866037|ref|NM_001012230.1|",1800,0,"Rattus norvegicus XK related, X-linked (Xkrx), mRNA","Q5GH60",852,0,"XK-related protein 2",".",".",".",".","pfam09815","XK-related","XK-related protein. Members of this family comprise various XK-related proteins, that are involved in sodium-dependent transport of neutral amino acids or oligopeptides. These proteins are responsible for the Kx blood group system - defects results in McLeod syndrome, an X-linked multi-system disorder characterized by late onset abnormalities in the neuromuscular and hematopoietic systems.",".",".",".",".","."]
["ENSRNOG00000004306",39,3.281275477,22,1.41526964,2.318480793,1.213179775,1.22652E-3,0.000929854,"up","yes","Zbtb39","protein_coding","chr7:63576917-63589210:+","gi|194474094|ref|NP_001124009.1|",3468,0,"zinc finger and BTB domain-containing protein 39 [Rattus norvegicus]","gi|194474093|ref|NM_001130537.1|",5832,0,"Rattus norvegicus zinc finger and BTB domain containing 39 (Zbtb39), mRNA","O15060",1179,0,"Zinc finger and BTB domain-containing protein 39",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;","GO:0005654|nucleoplasm;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;","K10511","ZBTB39; zinc finger and BTB domain-containing protein 39"]
["ENSRNOG00000062781",49,4.122628164,31,1.994243584,2.067264098,1.047722708,0.001280566,0.000968669,"up","yes","Ugt2b10","protein_coding","chr14:21108006-21127828:+","gi|300794198|ref|NP_001178605.1|",2688,0,"UDP-glucuronosyltransferase 2B10 precursor [Rattus norvegicus]","gi|300794197|ref|NM_001191676.1|",1599,0,"Rattus norvegicus UDP glucuronosyltransferase 2 family, polypeptide B10 (Ugt2b10), mRNA","Q6K1J1",766,0,"UDP-glucuronosyltransferase 2B31","slr1125",70.1,{"v":7e-12,"d":"7.00E-12"},"COG1819","pfam00201","UDPGT","UDP-glucoronosyl and UDP-glucosyl transferase.",".",".",".",".","."]
["ENSRNOG00000021260",17,1.430299567,5,0.321652191,4.446727264,2.152743921,1.290175E-3,0.000975125,"up","yes","Prnd","protein_coding","chr3:119213429-119218745:+","gi|564343103|ref|XP_006235118.1|",903,{"v":1e-110,"d":"1.00E-110"},"PREDICTED: prion-like protein doppel isoform X2 [Rattus norvegicus]","gi|672046747|ref|XM_006235058.2|",1759,0,"PREDICTED: Rattus norvegicus prion protein 2 (dublet) (Prnd), transcript variant X3, mRNA","Q9QUG3",319,{"v":6e-100,"d":"6.00E-100"},"Prion-like protein doppel",".",".",".",".","pfam00377","Prion","Prion/Doppel alpha-helical domain. The prion protein is thought to be the infectious agent that causes transmissible spongiform encephalopathies, such as scrapie and BSE. It is thought that the prion protein can exist in two different forms: one is the normal cellular protein, and the other is the infectious form which can change the normal prion protein into the infectious form. It has been found that the prion alpha-helical domain is also found in the Doppel protein.","GO:0006878|cellular copper ion homeostasis;GO:0007338|single fertilization;GO:0007340|acrosome reaction;GO:0051260|protein homooligomerization;","GO:0031362|anchored component of external side of plasma membrane;","GO:0005507|copper ion binding;",".","."]
["ENSRNOG00000067111",17,1.430299567,5,0.321652191,4.446727264,2.152743921,1.290175E-3,0.000975125,"up","yes","ENSRNOG00000067111","protein_coding","chr14:13850057-13852806:-","gi|672027701|ref|XP_008762845.1|",999,{"v":7e-132,"d":"7.00E-132"},"PREDICTED: PRAME family member 12-like isoform X1 [Rattus norvegicus]","gi|672027702|ref|XM_002724946.2|",566,0,"PREDICTED: Rattus norvegicus similar to PRAME family member 9 (LOC685782), transcript variant X2, mRNA","O95522",144,{"v":8e-38,"d":"8.00E-38"},"PRAME family member 12",".",".",".",".","pfam12799","LRR_4","Leucine Rich repeats (2 copies). Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.",".",".",".",".","."]
["ENSRNOG00000069883",17,1.430299567,5,0.321652191,4.446727264,2.152743921,1.290175E-3,0.000975125,"up","yes","ENSRNOG00000069883","lncRNA","chr19:39024185-39027888:-","gi|672031272|ref|XP_008772457.1|",518,{"v":7e-59,"d":"7.00E-59"},"PREDICTED: heterogeneous nuclear ribonucleoprotein C-like 1 isoform X3 [Rattus norvegicus]","gi|255004822|gb|AC111287.5|",1397,0,"Rattus norvegicus CH230-55H2 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam15240","Pro-rich","Proline-rich. This family includes several eukaryotic proline-rich proteins.",".",".",".",".","."]
["ENSRNOG00000005720",40,3.365410746,23,1.479600078,2.2745408,1.185575314,0.001305943,0.000985675,"up","yes","Spic","protein_coding","chr7:23069821-23077548:-","gi|564358895|ref|XP_006241285.1|",1292,{"v":2E-175,"d":"2.00E-175"},"PREDICTED: transcription factor Spi-C isoform X1 [Rattus norvegicus]","gi|672058223|ref|XM_006241223.2|",1302,0,"PREDICTED: Rattus norvegicus Spi-C transcription factor (Spi-1/PU.1 related) (Spic), transcript variant X1, mRNA","Q6P3D7",404,{"v":7E-139,"d":"7.00E-139"},"Transcription factor Spi-C",".",".",".",".","pfam00178","Ets","Ets-domain.","GO:0001824|blastocyst development;GO:0006357|regulation of transcription by RNA polymerase II;GO:0030154|cell differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;","K09440","SPIC; transcription factor Spi-C"]
["ENSRNOG00000051169",40,3.365410746,23,1.479600078,2.2745408,1.185575314,0.001305943,0.000985675,"up","yes","Clnk","protein_coding","chr14:71873105-72101208:+","gi|564384052|ref|XP_006251168.1|",2240,0,"PREDICTED: cytokine-dependent hematopoietic cell linker isoform X5 [Rattus norvegicus]","gi|672076488|ref|XM_006251106.2|",1937,0,"PREDICTED: Rattus norvegicus cytokine-dependent hematopoietic cell linker (Clnk), transcript variant X5, mRNA","Q9QZE2",683,0,"Cytokine-dependent hematopoietic cell linker",".",".",".",".","pfam00017","SH2","SH2 domain.","GO:0002729|positive regulation of natural killer cell cytokine production;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0010941|regulation of cell death;GO:0032815|negative regulation of natural killer cell activation;GO:0035556|intracellular signal transduction;GO:0043303|mast cell degranulation;","GO:0005737|cytoplasm;GO:0032991|protein-containing complex;GO:0042629|mast cell granule;","GO:0044877|protein-containing complex binding;",".","."]
["ENSRNOG00000003998",28,2.355787522,13,0.836295696,2.816931299,1.494124379,1.313172E-3,0.000990719,"up","yes","Sgca","protein_coding","chr10:79908738-79922813:-","gi|157823585|ref|NP_001100509.1|",1824,0,"alpha-sarcoglycan precursor [Rattus norvegicus]","gi|157823584|ref|NM_001107039.1|",1693,0,"Rattus norvegicus sarcoglycan, alpha (Sgca), mRNA","P82350",691,0,"Alpha-sarcoglycan",".",".",".",".","pfam05510","Sarcoglycan_2","Sarcoglycan alpha/epsilon. Sarcoglycans are a subcomplex of transmembrane proteins which are part of the dystrophin-glycoprotein complex. They are expressed in the skeletal, cardiac and smooth muscle. Although numerous studies have been conducted on the sarcoglycan subcomplex in skeletal and cardiac muscle, the manner of the distribution and localisation of these proteins along the nonjunctional sarcolemma is not clear. This family contains alpha and epsilon members.","GO:0014894|response to denervation involved in regulation of muscle adaptation;GO:0043403|skeletal muscle tissue regeneration;","GO:0005575|cellular_component;GO:0005856|cytoskeleton;GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0016011|dystroglycan complex;GO:0016012|sarcoglycan complex;GO:0016021|integral component of membrane;GO:0042383|sarcolemma;GO:0045121|membrane raft;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;","K12565","SGCA; alpha-sarcoglycan"]
["ENSRNOG00000064621",28,2.355787522,13,0.836295696,2.816931299,1.494124379,1.313172E-3,0.000990719,"up","yes","ENSRNOG00000064621","pseudogene","chr10:36275559-36276041:-","gi|31560385|ref|NP_062621.2|",760,{"v":7e-101,"d":"7.00E-101"},"60S ribosomal protein L21 [Mus musculus]","gi|189163511|ref|NG_007893.1|",245,{"v":8e-124,"d":"8.00E-124"},"Rattus norvegicus ribosomal protein L21, pseudogene 1 (Rpl21-ps1) on chromosome 9","P49666",297,{"v":2e-102,"d":"2.00E-102"},"60S ribosomal protein L21","YBR191w",176,{"v":1e-55,"d":"1.00E-55"},"COG2139","pfam01157","Ribosomal_L21e","Ribosomal protein L21e.",".",".",".",".","."]
["ENSRNOG00000071190",41,3.449546015,24,1.543930516,2.234262473,1.159798679,0.001383372,0.001039504,"up","yes","Pspn","protein_coding","chr9:1840896-1854327:-","gi|56090552|ref|NP_001007712.1|",1745,0,"general transcription factor IIF subunit 1 [Rattus norvegicus]","gi|672063948|ref|XM_006244321.2|",1801,0,"PREDICTED: Rattus norvegicus general transcription factor IIF, polypeptide 1 (Gtf2f1), transcript variant X1, mRNA","Q6AY96",676,0,"General transcription factor IIF subunit 1",".",".",".",".","pfam05793","TFIIF_alpha","Transcription initiation factor IIF, alpha subunit (TFIIF-alpha). Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) or RNA polymerase II-associating protein 74 (RAP74) is the large subunit of transcription factor IIF (TFIIF), which is essential for accurate initiation and stimulates elongation by RNA polymerase II.",".",".",".",".","."]
["ENSRNOG00000024257",29,2.439922791,14,0.900626135,2.70914056,1.437835248,1.484934E-3,0.001111526,"up","yes","Irgc","protein_coding","chr1:80020079-80025802:-","gi|62078763|ref|NP_001014038.1|",2334,0,"interferon-inducible GTPase 5 [Rattus norvegicus]","gi|672035037|ref|XM_006228427.2|",1572,0,"PREDICTED: Rattus norvegicus immunity-related GTPase family, cinema (Irgc), transcript variant X4, mRNA","Q6AYF9",903,0,"Interferon-inducible GTPase 5",".",".",".",".","pfam05049","IIGP","Interferon-inducible GTPase (IIGP). Interferon-inducible GTPase (IIGP) is thought to play a role in in intracellular defence. IIGP is predominantly associated with the Golgi apparatus and also localizes to the endoplasmic reticulum and exerts a distinct role in IFN-induced intracellular membrane trafficking or processing.","GO:0006952|defense response;GO:0035458|cellular response to interferon-beta;","GO:0005789|endoplasmic reticulum membrane;","GO:0003924|GTPase activity;GO:0005525|GTP binding;",".","."]
["ENSRNOG00000060435",43,3.617816552,26,1.672591393,2.163000819,1.113034211,1.53129E-3,0.001144023,"up","yes","Kcnq4","protein_coding","chr5:134275934-134326932:-","gi|293347610|ref|XP_001053765.2|",3135,0,"PREDICTED: potassium voltage-gated channel subfamily KQT member 4 isoform X1, partial [Rattus norvegicus]","gi|672053976|ref|XM_008764109.1|",3088,0,"PREDICTED: Rattus norvegicus potassium voltage-gated channel, KQT-like subfamily, member 4 (Kcnq4), transcript variant X1, mRNA","P56696",1199,0,"Potassium voltage-gated channel subfamily KQT member 4","STM1741",80.9,{"v":2e-15,"d":"2.00E-15"},"COG1226","pfam03520","KCNQ_channel","KCNQ voltage-gated potassium channel. This family matches to the C-terminal tail of KCNQ type potassium channels.","GO:0006813|potassium ion transport;GO:0007605|sensory perception of sound;GO:0032227|negative regulation of synaptic transmission, dopaminergic;GO:0034765|regulation of ion transmembrane transport;GO:0042472|inner ear morphogenesis;GO:0071805|potassium ion transmembrane transport;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0008076|voltage-gated potassium channel complex;GO:0009925|basal plasma membrane;GO:0016021|integral component of membrane;GO:0043005|neuron projection;","GO:0005249|voltage-gated potassium channel activity;GO:0005267|potassium channel activity;","K04929","KCNQ4, KV7.4; potassium voltage-gated channel KQT-like subfamily member 4"]
["ENSRNOG00000024553",44,3.70195182,27,1.736921831,2.131328972,1.091753291,1.6014E-3,0.001193617,"up","yes","Cyb5d2","protein_coding","chr10:57396765-57413715:-","gi|564372805|ref|XP_006246792.1|",1302,{"v":2E-175,"d":"2.00E-175"},"PREDICTED: neuferricin isoform X1 [Rattus norvegicus]","gi|672067933|ref|XM_006246730.2|",1231,0,"PREDICTED: Rattus norvegicus cytochrome b5 domain containing 2 (Cyb5d2), transcript variant X1, mRNA","Q6AY62",382,{"v":5e-128,"d":"5.00E-128"},"Neuferricin",".",".",".",".","pfam15498","Dendrin","Nephrin and CD2AP-binding protein, Dendrin. Dendrin is a family of eukaryotic proteins found in the podocytes of the kidneys. Dendrin, originally identified in telencephalic dendrites, is a constituent of the slit diaphragm, SD, complex of podocytes, where it directly binds to nephrin and CD2AP. Kidney podocytes and their slit diaphragms (SDs) form the final barrier to urinary protein loss. SD proteins also participate in intracellular signalling pathways. Dendrin appears to prevent programmed cell death (apoptosis) through its binding to nephrin. The SD protein nephrin serves as a component of a signalling complex that directly links podocyte junctional integrity to actin cytoskeletal dynamics. Thus, dendrin is identified as an SD family with proapoptotic signalling properties that accumulates in the podocyte nucleus in response to glomerular injury.","GO:0007399|nervous system development;GO:0045666|positive regulation of neuron differentiation;","GO:0005576|extracellular region;GO:0012505|endomembrane system;GO:0016020|membrane;","GO:0020037|heme binding;",".","."]
["ENSRNOG00000008010",21,1.766840642,8,0.514643505,3.43313502,1.779526598,1.60928E-3,0.001198835,"up","yes","Hoxb5","protein_coding","chr10:81269372-81271580:+","gi|556738352|ref|XP_005964751.1|",1075,{"v":3e-141,"d":"3.00E-141"},"PREDICTED: homeobox protein Hox-B5 [Pantholops hodgsonii]","gi|672068879|ref|XM_008768104.1|",1534,0,"PREDICTED: Rattus norvegicus homeo box B5 (Hoxb5), transcript variant X1, mRNA","P09079",414,{"v":7e-141,"d":"7.00E-141"},"Homeobox protein Hox-B5",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0009952|anterior/posterior pattern specification;GO:0045446|endothelial cell differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048704|embryonic skeletal system morphogenesis;GO:0048706|embryonic skeletal system development;","GO:0001650|fibrillar center;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:1990837|sequence-specific double-stranded DNA binding;","K09305","HOX_5; homeobox protein HoxA/B/C5"]
["ENSRNOG00000009052",21,1.766840642,8,0.514643505,3.43313502,1.779526598,1.60928E-3,0.001198835,"up","yes","Igf2bp3","protein_coding","chr4:78060494-78194865:-","gi|392339927|ref|XP_003753941.1|",2706,0,"PREDICTED: insulin-like growth factor 2 mRNA-binding protein 3 isoform X1 [Rattus norvegicus]","gi|672018272|ref|XM_003753893.3|",4038,0,"PREDICTED: Rattus norvegicus insulin-like growth factor 2 mRNA binding protein 3 (Igf2bp3), transcript variant X1, mRNA","Q9CPN8",1040,0,"Insulin-like growth factor 2 mRNA-binding protein 3",".",".",".",".","pfam00013","KH_1","KH domain. KH motifs bind RNA in vitro. Autoantibodies to Nova, a KH domain protein, cause paraneoplastic opsoclonus ataxia.","GO:0007399|nervous system development;GO:0010468|regulation of gene expression;GO:0051028|mRNA transport;GO:0051252|regulation of RNA metabolic process;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0003729|mRNA binding;GO:0003730|mRNA 3'-UTR binding;GO:0048027|mRNA 5'-UTR binding;","K13197","IGF2BP3; insulin-like growth factor 2 mRNA-binding protein 3"]
["ENSRNOG00000055790",25,2.103381716,11,0.70763482,2.972411273,1.571633746,1.627276E-3,1.211246E-3,"up","yes","Nup210l","protein_coding","chr2:175547988-175665332:+","gi|300798730|ref|NP_001178829.1|",10003,0,"nuclear pore membrane glycoprotein 210-like [Rattus norvegicus]","gi|300798729|ref|NM_001191900.1|",5637,0,"Rattus norvegicus nucleoporin 210-like (Nup210l), mRNA","Q9D2F7",3650,0,"Nuclear pore membrane glycoprotein 210-like",".",".",".",".","pfam02368","Big_2","Bacterial Ig-like domain (group 2). This family consists of bacterial domains with an Ig-like fold. Members of this family are found in bacterial and phage surface proteins such as intimins.","GO:0007286|spermatid development;GO:0060009|Sertoli cell development;","GO:0005643|nuclear pore;GO:0016021|integral component of membrane;",".","K14314","NUP210, GP210; nuclear pore complex protein Nup210"]
["ENSRNOG00000050670",15,1.26202903,4,0.257321753,4.9044786,2.29409977,1.669542E-3,1.241518E-3,"up","yes","L1td1","protein_coding","chr5:113379870-113385730:+","gi|880903732|ref|XP_012971938.1|",2555,0,"PREDICTED: LINE-1 type transposase domain-containing protein 1 [Mesocricetus auratus]","gi|124487094|ref|NM_001081202.1|",1299,0,"Mus musculus LINE-1 type transposase domain containing 1 (L1td1), mRNA","Q587J6",615,0,"LINE-1 type transposase domain-containing protein 1",".",".",".",".","pfam02994","Transposase_22","L1 transposable element.",".","GO:0043231|intracellular membrane-bounded organelle;",".",".","."]
["ENSRNOG00000058560",15,1.26202903,4,0.257321753,4.9044786,2.29409977,1.669542E-3,1.241518E-3,"up","yes","Col2a1","protein_coding","chr7:129098786-129127546:-","gi|6978677|ref|NP_037061.1|",1517,{"v":2E-180,"d":"2.00E-180"},"collagen alpha-1(II) chain precursor [Rattus norvegicus]","gi|672059833|ref|XM_006242308.2|",4601,0,"PREDICTED: Rattus norvegicus collagen, type II, alpha 1 (Col2a1), transcript variant X1, mRNA","P05539",577,{"v":2e-177,"d":"2.00E-177"},"Collagen alpha-1(II) chain",".",".",".",".","pfam01410","COLFI","Fibrillar collagen C-terminal domain. Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1 alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.","GO:0001501|skeletal system development;GO:0001502|cartilage condensation;GO:0001503|ossification;GO:0001894|tissue homeostasis;GO:0001958|endochondral ossification;GO:0002062|chondrocyte differentiation;GO:0003007|heart morphogenesis;GO:0003417|growth plate cartilage development;GO:0006029|proteoglycan metabolic process;GO:0007417|central nervous system development;GO:0007601|visual perception;GO:0007605|sensory perception of sound;GO:0009612|response to mechanical stimulus;GO:0010165|response to X-ray;GO:0010468|regulation of gene expression;GO:0030198|extracellular matrix organization;GO:0030199|collagen fibril organization;GO:0030903|notochord development;GO:0035108|limb morphogenesis;GO:0042472|inner ear morphogenesis;GO:0048705|skeletal system morphogenesis;GO:0048839|inner ear development;GO:0051216|cartilage development;GO:0060021|roof of mouth development;GO:0060174|limb bud formation;GO:0060272|embryonic skeletal joint morphogenesis;GO:0060348|bone development;GO:0060351|cartilage development involved in endochondral bone morphogenesis;GO:0071260|cellular response to mechanical stimulus;GO:0071300|cellular response to retinoic acid;GO:0071306|cellular response to vitamin E;GO:0071316|cellular response to nicotine;GO:0071356|cellular response to tumor necrosis factor;GO:0071374|cellular response to parathyroid hormone stimulus;GO:0071375|cellular response to peptide hormone stimulus;GO:0071599|otic vesicle development;GO:0071773|cellular response to BMP stimulus;GO:0071774|response to fibroblast growth factor;GO:0097065|anterior head development;GO:1990314|cellular response to insulin-like growth factor stimulus;GO:2001240|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;","GO:0005581|collagen trimer;GO:0005585|collagen type II trimer;GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0031012|extracellular matrix;GO:0062023|collagen-containing extracellular matrix;","GO:0005201|extracellular matrix structural constituent;GO:0042289|MHC class II protein binding;GO:0042802|identical protein binding;GO:0043394|proteoglycan binding;GO:0046872|metal ion binding;GO:0048407|platelet-derived growth factor binding;","K19719","COL2A; collagen type II alpha"]
["ENSRNOG00000066798",15,1.26202903,4,0.257321753,4.9044786,2.29409977,1.669542E-3,1.241518E-3,"up","yes","Peg10","protein_coding","chr4:32848493-32852621:+","gi|564303633|ref|XP_006224955.1|",2275,0,"PREDICTED: LOW QUALITY PROTEIN: retrotransposon-derived protein PEG10 isoform X1 [Rattus norvegicus]","gi|672018231|ref|XM_006224893.2|",1804,0,"PREDICTED: Rattus norvegicus paternally expressed 10 (Peg10), transcript variant X1, mRNA","Q7TN75",679,0,"Retrotransposon-derived protein PEG10",".",".",".",".","pfam03732","Retrotrans_gag","Retrotransposon gag protein. Gag or Capsid-like proteins from LTR retrotransposons. There is a central motif QGXXEXXXXXFXXLXXH that is common to Retroviridae gag-proteins, but is poorly conserved.",".",".",".",".","."]
["ENSRNOG00000001608",46,3.870222358,29,1.865582707,2.074538075,1.052790136,0.001733237,0.001285548,"up","yes","Nxpe3","protein_coding","chr11:44727069-44777694:+","gi|157821953|ref|NP_001102905.1|",2883,0,"NXPE family member 3 [Rattus norvegicus]","gi|157821952|ref|NM_001109435.1|",3137,0,"Rattus norvegicus neurexophilin and PC-esterase domain family, member 3 (Nxpe3), mRNA","Q5RCA5",1005,0,"NXPE family member 3",".",".",".",".","pfam06312","Neurexophilin","Neurexophilin. This family consists of mammalian neurexophilin proteins. Mammalian brains contain four different neurexophilin proteins. Neurexophilins form a family of related glycoproteins that are proteolytically processed after synthesis and bind to alpha-neurexins. The structure and characteristics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins.",".",".",".",".","."]
["ENSRNOG00000016877",37,3.11300494,21,1.350939202,2.304326453,1.204345118,1.744968E-3,0.001292665,"up","yes","Shisa7","protein_coding","chr1:68994025-69012943:+","gi|564326273|ref|XP_006228352.1|",2043,0,"PREDICTED: protein shisa-7 isoform X1 [Rattus norvegicus]","gi|223633885|ref|NM_001145175.1|",6089,0,"Rattus norvegicus shisa family member 7 (Shisa7), mRNA","Q8C3Q5",736,0,"Protein shisa-7",".",".",".",".","pfam13908","Shisa","Wnt and FGF inhibitory regulator. Shisa is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface.","GO:0007214|gamma-aminobutyric acid signaling pathway;GO:0007613|memory;GO:0048172|regulation of short-term neuronal synaptic plasticity;GO:0097112|gamma-aminobutyric acid receptor clustering;GO:0098962|regulation of postsynaptic neurotransmitter receptor activity;GO:0106040|regulation of GABA-A receptor activity;GO:1900273|positive regulation of long-term synaptic potentiation;GO:1904717|regulation of AMPA glutamate receptor clustering;GO:2000311|regulation of AMPA receptor activity;","GO:0014069|postsynaptic density;GO:0032281|AMPA glutamate receptor complex;GO:0032591|dendritic spine membrane;GO:0045211|postsynaptic membrane;GO:0098978|glutamatergic synapse;GO:0098985|asymmetric, glutamatergic, excitatory synapse;GO:0099060|integral component of postsynaptic specialization membrane;","GO:0035255|ionotropic glutamate receptor binding;GO:0050811|GABA receptor binding;",".","."]
["ENSRNOG00000018285",37,3.11300494,21,1.350939202,2.304326453,1.204345118,1.744968E-3,0.001292665,"up","yes","Kcna2","protein_coding","chr2:194704639-194718400:+","gi|25742772|ref|NP_037102.1|",2344,0,"potassium voltage-gated channel subfamily A member 2 [Rattus norvegicus]","gi|672043687|ref|XM_006233132.2|",11833,0,"PREDICTED: Rattus norvegicus potassium voltage-gated channel, shaker-related subfamily, member 2 (Kcna2), transcript variant X1, mRNA","P63142",907,0,"Potassium voltage-gated channel subfamily A member 2","DR0830",67.4,{"v":1E-10,"d":"1.00E-10"},"COG1226","pfam02214","BTB_2","BTB/POZ domain. In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.","GO:0014059|regulation of dopamine secretion;GO:0019228|neuronal action potential;GO:0019233|sensory perception of pain;GO:0021633|optic nerve structural organization;GO:0034765|regulation of ion transmembrane transport;GO:0045188|regulation of circadian sleep/wake cycle, non-REM sleep;GO:0051260|protein homooligomerization;GO:0071805|potassium ion transmembrane transport;GO:0097623|potassium ion export across plasma membrane;","GO:0005768|endosome;GO:0005789|endoplasmic reticulum membrane;GO:0005887|integral component of plasma membrane;GO:0008076|voltage-gated potassium channel complex;GO:0016021|integral component of membrane;GO:0030027|lamellipodium;GO:0030424|axon;GO:0030425|dendrite;GO:0031258|lamellipodium membrane;GO:0032809|neuronal cell body membrane;GO:0033010|paranodal junction;GO:0034705|potassium channel complex;GO:0043204|perikaryon;GO:0043679|axon terminus;GO:0044224|juxtaparanode region of axon;GO:0044305|calyx of Held;GO:0099056|integral component of presynaptic membrane;","GO:0005249|voltage-gated potassium channel activity;GO:0005251|delayed rectifier potassium channel activity;GO:0005515|protein binding;GO:0015271|outward rectifier potassium channel activity;GO:0019894|kinesin binding;","K04875","KCNA2, KV1.2; potassium voltage-gated channel Shaker-related subfamily A member 2"]
["ENSRNOG00000058912",37,3.11300494,21,1.350939202,2.304326453,1.204345118,1.744968E-3,0.001292665,"up","yes","ENSRNOG00000058912","protein_coding","chr20:5808860-5840172:+","gi|114145706|ref|NP_001041404.1|",2899,0,"uncharacterized protein LOC499407 [Rattus norvegicus]","gi|114145705|ref|NM_001047939.1|",2650,0,"Rattus norvegicus LRRGT00097 (LOC499407), mRNA",".",".",".",".",".",".",".",".","pfam11575","FhuF_C","FhuF 2Fe-2S C-terminal domain. This family consists of several bacterial ferric iron reductase protein (FhuF) sequences.  FhuF is involved in the reduction of ferric iron in cytoplasmic ferrioxamine B. This domain is the C-terminal domain that contains 4 conserved cysteine residues that are found to be part of a 2Fe-2S cluster.",".",".",".",".","."]
["ENSRNOG00000069762",18,1.514434836,6,0.385982629,3.92358288,1.972171675,1.747361E-3,0.001294261,"up","yes","MGC93861","protein_coding","chr1:240857263-240867394:+","gi|112983998|ref|NP_001037746.1|",1066,{"v":3e-129,"d":"3.00E-129"},"uncharacterized protein C10orf62 homolog [Rattus norvegicus]","gi|30315691|gb|AC131867.4|",4576,0,"Rattus norvegicus 1 BAC CH230-397C2 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam12852","Cupin_6","Cupin. This is a family of bacterial and eukaryotic proteins that belong to the Cupin superfamily. Some of the proteins in this family are annotated as being members of the AraC family of transcription factors, in which case this domain corresponds to the ligand binding domain.",".",".",".",".","."]
["ENSRNOG00000004003",26,2.187516985,12,0.771965258,2.833698747,1.502686392,1.875105E-3,1.381738E-3,"up","yes","Dusp10","protein_coding","chr13:95614292-95651716:+","gi|157787135|ref|NP_001099204.1|",2289,0,"dual specificity protein phosphatase 10 [Rattus norvegicus]","gi|157787134|ref|NM_001105734.1|",2701,0,"Rattus norvegicus dual specificity phosphatase 10 (Dusp10), mRNA","Q9ESS0",868,0,"Dual specificity protein phosphatase 10","YNL053w",69.7,{"v":2e-11,"d":"2.00E-11"},"COG2453","pfam00782","DSPc","Dual specificity phosphatase, catalytic domain. Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a \"recognition\" region.","GO:0002819|regulation of adaptive immune response;GO:0006470|protein dephosphorylation;GO:0010033|response to organic substance;GO:0010633|negative regulation of epithelial cell migration;GO:0016311|dephosphorylation;GO:0032496|response to lipopolysaccharide;GO:0032873|negative regulation of stress-activated MAPK cascade;GO:0035970|peptidyl-threonine dephosphorylation;GO:0043409|negative regulation of MAPK cascade;GO:0043508|negative regulation of JUN kinase activity;GO:0044387|negative regulation of protein kinase activity by regulation of protein phosphorylation;GO:0045088|regulation of innate immune response;GO:0045591|positive regulation of regulatory T cell differentiation;GO:0046329|negative regulation of JNK cascade;GO:0048709|oligodendrocyte differentiation;GO:0048715|negative regulation of oligodendrocyte differentiation;GO:0050680|negative regulation of epithelial cell proliferation;GO:0060266|negative regulation of respiratory burst involved in inflammatory response;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0090335|regulation of brown fat cell differentiation;GO:1903753|negative regulation of p38MAPK cascade;GO:1905042|negative regulation of epithelium regeneration;GO:1990264|peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0016607|nuclear speck;","GO:0003674|molecular_function;GO:0004721|phosphoprotein phosphatase activity;GO:0004725|protein tyrosine phosphatase activity;GO:0008330|protein tyrosine/threonine phosphatase activity;GO:0008432|JUN kinase binding;GO:0016791|phosphatase activity;GO:0017017|MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0033549|MAP kinase phosphatase activity;GO:0048273|mitogen-activated protein kinase p38 binding;","K20216","DUSP10; dual specificity phosphatase 10 [EC:3.1.3.16 3.1.3.48]"]
["ENSRNOG00000029394",26,2.187516985,12,0.771965258,2.833698747,1.502686392,1.875105E-3,1.381738E-3,"up","yes","Dusp8","protein_coding","chr1:197169422-197182921:-","gi|157817789|ref|NP_001101980.1|",2504,0,"dual specificity protein phosphatase 8 [Rattus norvegicus]","gi|157817788|ref|NM_001108510.1|",2439,0,"Rattus norvegicus dual specificity phosphatase 8 (Dusp8), mRNA","O09112",843,0,"Dual specificity protein phosphatase 8","SPBC17A3.06",85.5,{"v":4e-17,"d":"4.00E-17"},"COG2453","pfam00782","DSPc","Dual specificity phosphatase, catalytic domain. Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a \"recognition\" region.","GO:0008150|biological_process;GO:0016311|dephosphorylation;","GO:0005575|cellular_component;","GO:0003674|molecular_function;GO:0004725|protein tyrosine phosphatase activity;GO:0016791|phosphatase activity;","K04459","DUSP, MKP; dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48]"]
["ENSRNOG00000039463",26,2.187516985,12,0.771965258,2.833698747,1.502686392,1.875105E-3,1.381738E-3,"up","yes","Pcdhga1","lncRNA","chr18:29487482-29492857:-","gi|80751173|ref|NP_001032217.1|",3938,0,"protocadherin gamma-A1 precursor [Rattus norvegicus]","gi|13899409|gb|AC020971.3|AC020971",2420,0,"Mus musculus chromosome 18 clone RP23-56B11, complete sequence","Q9Y5H4",1280,0,"Protocadherin gamma-A1",".",".",".",".","pfam08266","Cadherin_2","Cadherin-like. This cadherin domain is usually the most N-terminal copy of the domain.",".",".",".",".","."]
["ENSRNOG00000068754",26,2.187516985,12,0.771965258,2.833698747,1.502686392,1.875105E-3,1.381738E-3,"up","yes","Cd244","protein_coding","chr13:84020095-84036100:+","gi|11560073|ref|NP_071595.1|",1625,0,"natural killer cell receptor 2B4 precursor [Rattus norvegicus]","gi|11560072|ref|NM_022259.1|",1346,0,"Rattus norvegicus CD244 molecule (Cd244), mRNA","Q9JLM2",630,0,"Natural killer cell receptor 2B4",".",".",".",".","pfam11465","Receptor_2B4","Natural killer cell receptor 2B4. 2B4 is a transmembrane receptor which is expressed primarily on natural killer cells. It plays a role in activating NK-mediated cytotoxicity through its interaction with CD48 on target cells in a subset of CD8 T cells. The structure of 2B4 consists of an immunoglobulin variable domain fold and contains two beta-sheets. One of the beta-sheets, the six-stranded sheet, contains structural features that may have a role in ligand recognition and receptor function.",".",".",".",".","."]
["ENSRNOG00000070630",26,2.187516985,12,0.771965258,2.833698747,1.502686392,1.875105E-3,1.381738E-3,"up","yes","ENSRNOG00000070630","lncRNA","chr20:7144999-7149171:-",".",".",".",".","gi|672031552|ref|XR_343719.2|",645,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102557535 (LOC102557535), ncRNA",".",".",".",".",".",".",".",".","pfam15498","Dendrin","Nephrin and CD2AP-binding protein, Dendrin. Dendrin is a family of eukaryotic proteins found in the podocytes of the kidneys. Dendrin, originally identified in telencephalic dendrites, is a constituent of the slit diaphragm, SD, complex of podocytes, where it directly binds to nephrin and CD2AP. Kidney podocytes and their slit diaphragms (SDs) form the final barrier to urinary protein loss. SD proteins also participate in intracellular signalling pathways. Dendrin appears to prevent programmed cell death (apoptosis) through its binding to nephrin. The SD protein nephrin serves as a component of a signalling complex that directly links podocyte junctional integrity to actin cytoskeletal dynamics. Thus, dendrin is identified as an SD family with proapoptotic signalling properties that accumulates in the podocyte nucleus in response to glomerular injury.",".",".",".",".","."]
["ENSRNOG00000014650",39,3.281275477,23,1.479600078,2.21767728,1.149049438,0.001961681,1.441632E-3,"up","yes","Sema4g","protein_coding","chr1:243853854-243865341:+","gi|209862780|ref|NP_001101996.1|",3831,0,"semaphorin-4G precursor [Rattus norvegicus]","gi|672040488|ref|XM_006231528.2|",4326,0,"PREDICTED: Rattus norvegicus sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G (Sema4g), transcript variant X1, mRNA","Q9WUH7",1436,0,"Semaphorin-4G",".",".",".",".","pfam01403","Sema","Sema domain. The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and human plexin A-3.","GO:0001755|neural crest cell migration;GO:0007411|axon guidance;GO:0030335|positive regulation of cell migration;GO:0048843|negative regulation of axon extension involved in axon guidance;GO:0050919|negative chemotaxis;GO:0071526|semaphorin-plexin signaling pathway;","GO:0005615|extracellular space;GO:0005887|integral component of plasma membrane;","GO:0030215|semaphorin receptor binding;GO:0045499|chemorepellent activity;","K06521","SEMA4, CD100; semaphorin 4"]
["ENSRNOG00000070627",32,2.692328597,17,1.093617449,2.461855925,1.299746333,0.001998684,1.46645E-3,"up","yes","ENSRNOG00000070627","protein_coding","chr3:162364896-162375596:-","gi|672048513|ref|XP_008760837.1|",1165,{"v":9e-149,"d":"9.00E-149"},"PREDICTED: ankyrin repeat domain-containing protein 60 isoform X2 [Rattus norvegicus]","gi|672048512|ref|XM_008762615.1|",748,0,"PREDICTED: Rattus norvegicus ankyrin repeat domain 60 (Ankrd60), transcript variant X2, mRNA",".",".",".",".","all2748",67.4,{"v":9e-11,"d":"9.00E-11"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).",".",".",".",".","."]
["ENSRNOG00000017381",13,1.093758492,3,0.192991315,5.667397494,2.502686392,0.002075836,0.001517943,"up","yes","Itih4","protein_coding","chr16:6080539-6095708:+","gi|126722991|ref|NP_062242.2|",4701,0,"inter-alpha-trypsin inhibitor heavy chain H4 precursor [Rattus norvegicus]","gi|126722990|ref|NM_019369.2|",2962,0,"Rattus norvegicus inter-alpha-trypsin inhibitor heavy chain family, member 4 (Itih4), mRNA","A6X935",1493,0,"Inter alpha-trypsin inhibitor, heavy chain 4","alr4412",110,{"v":1e-23,"d":"1.00E-23"},"COG2304","pfam08487","VIT","Vault protein inter-alpha-trypsin domain. Inter-alpha-trypsin inhibitors (ITIs) consist of one light chain and a variable set of heavy chains. ITIs play a role in extracellular matrix (ECM) stabilisation and tumor metastasis as well as in plasma protease inhibition. The vault protein inter-alpha-trypsin (VIT) domain described here is found to the N-terminus of a von Willebrand factor type A domain (pfam00092) in ITI heavy chains (ITIHs) and their precursors.","GO:0006953|acute-phase response;GO:0008150|biological_process;GO:0010951|negative regulation of endopeptidase activity;GO:0030212|hyaluronan metabolic process;GO:0034097|response to cytokine;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005886|plasma membrane;","GO:0003674|molecular_function;GO:0004867|serine-type endopeptidase inhibitor activity;","K24514","ITIH4; inter-alpha-trypsin inhibitor heavy chain H4"]
["ENSRNOG00000037027",13,1.093758492,3,0.192991315,5.667397494,2.502686392,0.002075836,0.001517943,"up","yes","ENSRNOG00000037027","protein_coding","chr5:156616340-156660184:-","gi|109475829|ref|XP_001077182.1|",2158,0,"PREDICTED: arylacetamide deacetylase-like 4 [Rattus norvegicus]","gi|672020080|ref|XM_002726650.2|",1227,0,"PREDICTED: Rattus norvegicus similar to arylacetamide deacetylase (LOC691196), mRNA","Q5VUY2",566,0,"Arylacetamide deacetylase-like 4","TVN0727",96.7,{"v":1e-21,"d":"1.00E-21"},"COG0657","pfam07859","Abhydrolase_3","alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.",".","GO:0016021|integral component of membrane;","GO:0016787|hydrolase activity;GO:0052689|carboxylic ester hydrolase activity;","K14351","AADACL3_4; arylacetamide deacetylase-like 3/4 [EC:3.1.1.-]"]
["ENSRNOG00000037485",13,1.093758492,3,0.192991315,5.667397494,2.502686392,0.002075836,0.001517943,"up","yes","ENSRNOG00000037485","protein_coding","chr1:85949096-85949889:+","gi|157817039|ref|NP_001102989.1|",594,{"v":4e-76,"d":"4.00E-76"},"uncharacterized protein LOC688924 [Rattus norvegicus]","gi|672035882|ref|XM_008759195.1|",493,0,"PREDICTED: Rattus norvegicus hypothetical protein LOC688924 (LOC688924), transcript variant X7, mRNA",".",".",".",".",".",".",".",".","pfam04505","Dispanin","Interferon-induced transmembrane protein. This family includes the human leukocyte antigen CD225, which is an interferon inducible transmembrane protein, and is associated with interferon induced cell growth suppression.",".","GO:0016020|membrane;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000062933",13,1.093758492,3,0.192991315,5.667397494,2.502686392,0.002075836,0.001517943,"up","yes","ENSRNOG00000062933","pseudogene","chr10:101892786-101901674:+","gi|74209506|dbj|BAE23299.1|",313,{"v":8e-35,"d":"8.00E-35"},"unnamed protein product [Mus musculus]","gi|672025503|ref|XM_006220946.2|",275,{"v":1e-140,"d":"1.00E-140"},"PREDICTED: Rattus norvegicus uncharacterized LOC100912216 (LOC100912216), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam15292","Treslin_N","Treslin N-terminus. This family represents the N-terminus of treslin, a checkpoint regulator which plays a role in DNA replication preinitiation complex formation.",".",".",".",".","."]
["ENSRNOG00000068149",41,3.449546015,25,1.608260955,2.144891975,1.10090499,2.163342E-3,0.001576216,"up","yes","ENSRNOG00000068149","lncRNA","chr18:31235874-31237913:+",".",".",".",".","gi|672083164|ref|XM_006254663.2|",2040,0,"PREDICTED: Rattus norvegicus Rho GTPase activating protein 26 (Arhgap26), transcript variant X4, mRNA",".",".",".",".",".",".",".",".","pfam05024","Gpi1","N-acetylglucosaminyl transferase component (Gpi1). Glycosylphosphatidylinositol (GPI) represents an important anchoring molecule for cell surface proteins.The first step in its synthesis is the transfer of N-acetylglucosamine (GlcNAc) from UDP-N-acetylglucosamine to phosphatidylinositol (PI). This chemically simple step is genetically complex because three or four genes are required in both yeast (GPI1, GPI2 and GPI3) and mammals (GPI1, PIG A, PIG H and PIG C), respectively.",".",".",".",".","."]
["ENSRNOG00000000522",19,1.598570104,7,0.450313067,3.54990832,1.827781766,0.00224343,1.62977E-3,"up","yes","Cpne5","protein_coding","chr20:7206742-7288883:-","gi|569000237|ref|XP_006524312.1|",3067,0,"PREDICTED: copine-5 isoform X1 [Mus musculus]","gi|157821438|ref|NM_001107616.1|",3714,0,"Rattus norvegicus copine 5 (Cpne5), mRNA","Q8JZW4",1140,0,"Copine-5","YOR086c",55.1,{"v":2e-06,"d":"2.00E-06"},"COG5038","pfam07002","Copine","Copine. This family represents a conserved region approximately 180 residues long within eukaryotic copines. Copines are Ca(2+)-dependent phospholipid-binding proteins that are thought to be involved in membrane-trafficking, and may also be involved in cell division and growth.","GO:0071277|cellular response to calcium ion;GO:1903861|positive regulation of dendrite extension;","GO:0005886|plasma membrane;GO:0043005|neuron projection;GO:0043025|neuronal cell body;","GO:0005544|calcium-dependent phospholipid binding;","K24523","CPNE5_8_9; copine 5/8/9"]
["ENSRNOG00000002013",8,0.673082149,0,0.032165219,20.92577536,4.387209175,2.253138E-3,0.00163486,"up","yes","Sidt1","protein_coding","chr11:56363512-56459050:+","gi|281306752|ref|NP_001094123.1|",3592,0,"SID1 transmembrane family member 1 precursor [Rattus norvegicus]","gi|281306751|ref|NM_001100653.1|",3495,0,"Rattus norvegicus SID1 transmembrane family, member 1 (Sidt1), mRNA","Q6Q3F5",1388,0,"SID1 transmembrane family member 1",".",".",".",".","pfam13965","SID-1_RNA_chan","dsRNA-gated channel SID-1. This is a family of proteins that are transmembrane dsRNA-gated channels. They passively transport dsRNA into cells and do not act as ATP-dependent pumps. They are required for systemic RNA interference.","GO:0050658|RNA transport;","GO:0005764|lysosome;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0003725|double-stranded RNA binding;GO:0015485|cholesterol binding;GO:0051033|RNA transmembrane transporter activity;",".","."]
["ENSRNOG00000011460",8,0.673082149,0,0.032165219,20.92577536,4.387209175,2.253138E-3,0.00163486,"up","yes","Arfgef3","protein_coding","chr1:13244830-13404084:-","gi|109460492|ref|XP_001072524.1|",10715,0,"PREDICTED: brefeldin A-inhibited guanine nucleotide-exchange protein 3 isoform X1 [Rattus norvegicus]","gi|672012479|ref|XM_001072524.5|",8054,0,"PREDICTED: Rattus norvegicus similar to mKIAA1244 protein (RGD1309903), transcript variant X1, mRNA","Q3UGY8",4004,0,"Brefeldin A-inhibited guanine nucleotide-exchange protein 3",".",".",".",".","pfam09324","DUF1981","Domain of unknown function (DUF1981). Members of this family of functionally uncharacterized domains are found in various plant and yeast protein transport proteins.","GO:0030036|actin cytoskeleton organization;GO:0032012|regulation of ARF protein signal transduction;GO:0050790|regulation of catalytic activity;",".","GO:0005085|guanyl-nucleotide exchange factor activity;","K17572","ARFGEF3, KEPI; brefeldin A-inhibited guanine nucleotide-exchange protein 3"]
["ENSRNOG00000033251",8,0.673082149,0,0.032165219,20.92577536,4.387209175,2.253138E-3,0.00163486,"up","yes","Slc25a52","pseudogene","chr14:45396213-45398330:-","gi|34877540|ref|XP_223434.2|",1591,0,"PREDICTED: solute carrier family 25 member 51 [Rattus norvegicus]","gi|63101566|gb|BC094527.1|",1800,0,"Rattus norvegicus mitochondrial carrier triple repeat 1, mRNA (cDNA clone MGC:105623 IMAGE:7318312), complete cds","Q52KK3",586,0,"Solute carrier family 25 member 51",".",".",".",".","pfam00153","Mito_carr","Mitochondrial carrier protein.",".",".",".",".","."]
["ENSRNOG00000040120",8,0.673082149,0,0.032165219,20.92577536,4.387209175,2.253138E-3,0.00163486,"up","yes","Bhmt2","protein_coding","chr2:24895533-24912475:-","gi|158081741|ref|NP_001014278.2|",1764,0,"S-methylmethionine--homocysteine S-methyltransferase BHMT2 [Rattus norvegicus]","gi|158081740|ref|NM_001014256.2|",1966,0,"Rattus norvegicus betaine-homocysteine S-methyltransferase 2 (Bhmt2), mRNA","Q68FT5",681,0,"S-methylmethionine--homocysteine S-methyltransferase BHMT2","BS_yitJ_1",80.1,{"v":1e-15,"d":"1.00E-15"},"COG0646","pfam02574","S-methyl_trans","Homocysteine S-methyltransferase. This is a family of related homocysteine S-methyltransferases enzymes: 5-methyltetrahydrofolate--homocysteine S-methyltransferases also known EC:2.1.1.13; Betaine--homocysteine S-methyltransferase (vitamin B12 dependent), EC:2.1.1.5,; and Homocysteine S-methyltransferase, EC:2.1.1.10,.","GO:0032259|methylation;GO:0033477|S-methylmethionine metabolic process;GO:0046500|S-adenosylmethionine metabolic process;GO:0071267|L-methionine salvage;",".","GO:0008270|zinc ion binding;GO:0047150|betaine-homocysteine S-methyltransferase activity;GO:0061627|S-methylmethionine-homocysteine S-methyltransferase activity;","K00547","mmuM, BHMT2; homocysteine S-methyltransferase [EC:2.1.1.10]"]
["ENSRNOG00000046076",8,0.673082149,0,0.032165219,20.92577536,4.387209175,2.253138E-3,0.00163486,"up","yes","Tspan10","protein_coding","chr10:105715961-105719813:+","gi|672025580|ref|XP_006221038.2|",1324,0,"PREDICTED: tetraspanin-10 [Rattus norvegicus]","gi|672025579|ref|XM_006220976.2|",991,0,"PREDICTED: Rattus norvegicus tetraspanin 10 (Tspan10), mRNA","Q8VCF5",428,{"v":3E-148,"d":"3.00E-148"},"Tetraspanin-10",".",".",".",".","pfam00335","Tetraspannin","Tetraspanin family.","GO:0051604|protein maturation;GO:0072594|establishment of protein localization to organelle;","GO:0005887|integral component of plasma membrane;","GO:0019899|enzyme binding;","K17351","TSPAN10; tetraspanin-10"]
["ENSRNOG00000047431",8,0.673082149,0,0.032165219,20.92577536,4.387209175,2.253138E-3,0.00163486,"up","yes","Tmem262","protein_coding","chr1:203373812-203374528:+","gi|336391138|ref|NP_001229562.1|",608,{"v":3e-78,"d":"3.00E-78"},"transmembrane protein 262 [Rattus norvegicus]","gi|336391137|ref|NM_001242633.1|",511,0,"Rattus norvegicus transmembrane protein 262 (Tmem262), mRNA","E9PQX1",175,{"v":9e-55,"d":"9.00E-55"},"Transmembrane protein 262",".",".",".",".","pfam06728","PIG-U","GPI transamidase subunit PIG-U. Many eukaryotic proteins are anchored to the cell surface via glycosylphosphatidylinositol (GPI), which is posttranslationally attached to the carboxyl-terminus by GPI transamidase. The mammalian GPI transamidase is a complex of at least four subunits, GPI8, GAA1, PIG-S, and PIG-T. PIG-U is thought to represent a fifth subunit in this complex and may be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000068561",8,0.673082149,0,0.032165219,20.92577536,4.387209175,2.253138E-3,0.00163486,"up","yes","ENSRNOG00000068561","protein_coding","chr11:64531612-64533989:+","gi|564314485|ref|XP_006221213.1|",537,{"v":4e-68,"d":"4.00E-68"},"PREDICTED: stefin-2-like isoform X1 [Rattus norvegicus]","gi|564314484|ref|XM_006221151.1|",403,0,"PREDICTED: Rattus norvegicus stefin A2-like 3 (Stfa2l3), transcript variant X1, mRNA","P35174",159,{"v":5e-49,"d":"5.00E-49"},"Stefin-2",".",".",".",".","pfam00031","Cystatin","Cystatin domain. Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 are related to this family but have not been included.",".",".",".",".","."]
["ENSRNOG00000069347",8,0.673082149,0,0.032165219,20.92577536,4.387209175,2.253138E-3,0.00163486,"up","yes","ENSRNOG00000069347","lncRNA","chr8:73241794-73244009:+","gi|148694313|gb|EDL26260.1|",247,{"v":6e-23,"d":"6.00E-23"},"mCG1035306, isoform CRA_a [Mus musculus]","gi|354781770|gb|JN946271.1|",92,{"v":2e-38,"d":"2.00E-38"},"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele 4930519F16Rik:tm1a(EUCOMM)Hmgu; transgenic",".",".",".",".",".",".",".",".","pfam01826","TIL","Trypsin Inhibitor like cysteine rich domain. This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.",".",".",".",".","."]
["ENSRNOG00000071034",23,1.935111179,10,0.643304382,3.008080208,1.588843036,2.316743E-3,1.67855E-3,"up","yes","ENSRNOG00000071034","protein_coding","chr7:16170784-16348939:-","gi|392349284|ref|XP_234980.5|",2184,0,"PREDICTED: sperm motility kinase W-like [Rattus norvegicus]","gi|672058333|ref|XM_008765270.1|",3852,0,"PREDICTED: Rattus norvegicus similar to hypothetical protein 4930509O22 (RGD1566251), transcript variant X4, mRNA","Q8C0V7",575,0,"Putative sperm motility kinase W",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.",".",".",".",".","."]
["ENSRNOG00000050220",34,2.860599134,19,1.222278326,2.340382771,1.226744503,0.002327603,0.001685074,"up","yes","Nrxn1","protein_coding","chr6:3177897-4322710:+","gi|37620151|ref|NP_068535.2|",7463,0,"neurexin 1 precursor [Rattus norvegicus]","gi|755556145|ref|XM_006523812.2|",5269,0,"PREDICTED: Mus musculus neurexin I (Nrxn1), transcript variant X8, mRNA","Q63372",2865,0,"Neurexin-1",".",".",".",".","pfam02210","Laminin_G_2","Laminin G domain. This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.","GO:0001525|angiogenesis;GO:0006904|vesicle docking involved in exocytosis;GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007158|neuron cell-cell adhesion;GO:0007165|signal transduction;GO:0007268|chemical synaptic transmission;GO:0007269|neurotransmitter secretion;GO:0007416|synapse assembly;GO:0007612|learning;GO:0007623|circadian rhythm;GO:0010628|positive regulation of gene expression;GO:0010629|negative regulation of gene expression;GO:0010739|positive regulation of protein kinase A signaling;GO:0016339|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0021707|cerebellar granule cell differentiation;GO:0030534|adult behavior;GO:0031175|neuron projection development;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0035176|social behavior;GO:0035418|protein localization to synapse;GO:0042297|vocal learning;GO:0042551|neuron maturation;GO:0045184|establishment of protein localization;GO:0045743|positive regulation of fibroblast growth factor receptor signaling pathway;GO:0046847|filopodium assembly;GO:0050885|neuromuscular process controlling balance;GO:0051490|negative regulation of filopodium assembly;GO:0051897|positive regulation of protein kinase B signaling;GO:0051965|positive regulation of synapse assembly;GO:0051968|positive regulation of synaptic transmission, glutamatergic;GO:0060134|prepulse inhibition;GO:0061178|regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0071277|cellular response to calcium ion;GO:0071625|vocalization behavior;GO:0090126|protein-containing complex assembly involved in synapse maturation;GO:0090129|positive regulation of synapse maturation;GO:0097091|synaptic vesicle clustering;GO:0097104|postsynaptic membrane assembly;GO:0097105|presynaptic membrane assembly;GO:0097112|gamma-aminobutyric acid receptor clustering;GO:0097114|NMDA glutamate receptor clustering;GO:0097116|gephyrin clustering involved in postsynaptic density assembly;GO:0097117|guanylate kinase-associated protein clustering;GO:0097118|neuroligin clustering involved in postsynaptic membrane assembly;GO:0097119|postsynaptic density protein 95 clustering;GO:0097120|receptor localization to synapse;GO:0098693|regulation of synaptic vesicle cycle;GO:0099054|presynapse assembly;GO:0099150|regulation of postsynaptic specialization assembly;GO:0099151|regulation of postsynaptic density assembly;GO:0099542|trans-synaptic signaling by endocannabinoid;GO:0099560|synaptic membrane adhesion;GO:1900020|positive regulation of protein kinase C activity;GO:1903078|positive regulation of protein localization to plasma membrane;GO:1905520|positive regulation of presynaptic active zone assembly;GO:1905606|regulation of presynapse assembly;GO:2000310|regulation of NMDA receptor activity;GO:2000311|regulation of AMPA receptor activity;GO:2000463|positive regulation of excitatory postsynaptic potential;GO:2000821|regulation of grooming behavior;","GO:0005730|nucleolus;GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0030139|endocytic vesicle;GO:0031965|nuclear membrane;GO:0031982|vesicle;GO:0032991|protein-containing complex;GO:0036057|slit diaphragm;GO:0042734|presynaptic membrane;GO:0043025|neuronal cell body;GO:0044295|axonal growth cone;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098978|glutamatergic synapse;GO:0098982|GABA-ergic synapse;GO:0099056|integral component of presynaptic membrane;GO:0099059|integral component of presynaptic active zone membrane;","GO:0004888|transmembrane signaling receptor activity;GO:0005102|signaling receptor binding;GO:0005105|type 1 fibroblast growth factor receptor binding;GO:0005246|calcium channel regulator activity;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0033130|acetylcholine receptor binding;GO:0044877|protein-containing complex binding;GO:0046872|metal ion binding;GO:0048306|calcium-dependent protein binding;GO:0050839|cell adhesion molecule binding;GO:0097109|neuroligin family protein binding;","K07377","NRXN; neurexin"]
["ENSRNOG00000010480",11,0.925487955,2,0.128660876,7.19323528,2.846640793,0.00240315,0.001736073,"up","yes","Vstm5","protein_coding","chr8:12080203-12100427:+","gi|56789732|gb|AAH88439.1|",993,{"v":2e-128,"d":"2.00E-128"},"LOC500947 protein [Rattus norvegicus]","gi|221554521|ref|NM_001144870.1|",1849,0,"Rattus norvegicus V-set and transmembrane domain containing 5 (Vstm5), mRNA","Q5M7U7",376,{"v":7E-126,"d":"7.00E-126"},"V-set and transmembrane domain-containing protein 5",".",".",".",".","pfam01500","Keratin_B2","Keratin, high sulfur B2 protein. High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.","GO:0021517|ventral spinal cord development;GO:0046847|filopodium assembly;GO:0051260|protein homooligomerization;GO:1904891|positive regulation of excitatory synapse assembly;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0030425|dendrite;",".",".","."]
["ENSRNOG00000018822",11,0.925487955,2,0.128660876,7.19323528,2.846640793,0.00240315,0.001736073,"up","yes","Slc5a5","protein_coding","chr16:18546709-18556697:+","gi|158138505|ref|NP_443215.2|",2945,0,"sodium/iodide cotransporter [Rattus norvegicus]","gi|158138504|ref|NM_052983.2|",2845,0,"Rattus norvegicus solute carrier family 5 (sodium/iodide cotransporter), member 5 (Slc5a5), mRNA","Q63008",1137,0,"Sodium/iodide cotransporter","sll1087",154,{"v":9e-39,"d":"9.00E-39"},"COG0591","pfam00474","SSF","Sodium:solute symporter family. Membership of this family is supported by a significant blast score.","GO:0006590|thyroid hormone generation;GO:0006814|sodium ion transport;GO:0015705|iodide transport;GO:0071320|cellular response to cAMP;GO:0071371|cellular response to gonadotropin stimulus;GO:1904200|iodide transmembrane transport;","GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0008507|sodium:iodide symporter activity;GO:0015111|iodide transmembrane transporter activity;GO:0015293|symporter activity;","K14385","SLC5A5, NIS; solute carrier family 5 (sodium/iodide cotransporter), member 5"]
["ENSRNOG00000021123",11,0.925487955,2,0.128660876,7.19323528,2.846640793,0.00240315,0.001736073,"up","yes","AC098622.1","protein_coding","chr1:204055499-204077329:+","gi|674059777|ref|XP_008836516.1|",328,{"v":2E-35,"d":"2.00E-35"},"PREDICTED: ATP synthase F(0) complex subunit C1, mitochondrial [Nannospalax galili]","gi|672068534|ref|XM_006247188.2|",258,{"v":6e-131,"d":"6.00E-131"},"PREDICTED: Rattus norvegicus ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9) (Atp5g1), transcript variant X1, mRNA","Q06645",129,{"v":2e-36,"d":"2.00E-36"},"ATP synthase F(0) complex subunit C1, mitochondrial","Q0130",59.3,{"v":3E-11,"d":"3.00E-11"},"COG0636","pfam00137","ATP-synt_C","ATP synthase subunit C.",".",".",".",".","."]
["ENSRNOG00000030983",11,0.925487955,2,0.128660876,7.19323528,2.846640793,0.00240315,0.001736073,"up","yes","B3galt5","protein_coding","chr11:35585220-35630917:+","gi|157786822|ref|NP_001099357.1|",1590,0,"beta-1,3-galactosyltransferase 5 [Rattus norvegicus]","gi|672070546|ref|XM_008768569.1|",5164,0,"PREDICTED: Rattus norvegicus UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 (B3galt5), transcript variant X1, mRNA","Q9JI67",596,0,"Beta-1,3-galactosyltransferase 5",".",".",".",".","pfam01762","Galactosyl_T","Galactosyltransferase. This family includes the galactosyltransferases UDP-galactose:2-acetamido-2-deoxy-D-glucose3beta-galactosyltransferase and UDP-Gal:beta-GlcNAc beta 1,3-galactosyltranferase. Specific galactosyltransferases transfer galactose to GlcNAc terminal chains in the synthesis of the lacto-series oligosaccharides types 1 and 2.","GO:0006486|protein glycosylation;GO:0008150|biological_process;GO:0009617|response to bacterium;","GO:0000139|Golgi membrane;GO:0005575|cellular_component;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0008194|UDP-glycosyltransferase activity;GO:0008499|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity;GO:0016757|transferase activity, transferring glycosyl groups;","K03877","B3GALT5; beta-1,3-galactosyltransferase 5 [EC:2.4.1.-]"]
["ENSRNOG00000042601",11,0.925487955,2,0.128660876,7.19323528,2.846640793,0.00240315,0.001736073,"up","yes","Zglp1","protein_coding","chr8:19599998-19604547:-","gi|564309626|ref|XP_006226374.1|",1435,0,"PREDICTED: GATA-type zinc finger protein 1 [Rattus norvegicus]","gi|672022571|ref|XM_006226312.2|",955,0,"PREDICTED: Rattus norvegicus zinc finger, GATA-like protein 1 (Zglp1), mRNA","Q1WG82",509,0,"GATA-type zinc finger protein 1","ECU08g1400",52,{"v":5e-07,"d":"5.00E-07"},"COG5641","pfam00320","GATA","GATA zinc finger. This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contains a single copy of the domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007283|spermatogenesis;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048599|oocyte development;","GO:0005634|nucleus;","GO:0008270|zinc ion binding;GO:0043565|sequence-specific DNA binding;","K21630","ZGLP1; GATA-type zinc finger protein 1"]
["ENSRNOG00000065110",11,0.925487955,2,0.128660876,7.19323528,2.846640793,0.00240315,0.001736073,"up","yes","ENSRNOG00000065110","protein_coding","chr18:27483729-27499090:+","gi|166796835|gb|AAI59439.1|",640,{"v":3e-80,"d":"3.00E-80"},"Rps16 protein [Rattus norvegicus]","gi|298904831|emb|FQ228433.1|",423,0,"Rattus norvegicus TL0ADA8YI12 mRNA sequence","P62250",229,{"v":2E-73,"d":"2.00E-73"},"40S ribosomal protein S16","SPBC18H10.14",160,{"v":3e-47,"d":"3.00E-47"},"COG0103","pfam00380","Ribosomal_S9","Ribosomal protein S9/S16. This family includes small ribosomal subunit S9 from prokaryotes and S16 from eukaryotes.",".",".",".",".","."]
["ENSRNOG00000001915",9,0.757217418,1,0.064330438,11.77074864,3.557134176,0.002418645,0.001743104,"up","yes","Chodl","protein_coding","chr11:17654206-17676441:+","gi|157787048|ref|NP_001099364.1|",1508,0,"chondrolectin precursor [Rattus norvegicus]","gi|157787047|ref|NM_001105894.1|",2319,0,"Rattus norvegicus chondrolectin (Chodl), mRNA","Q9CXM0",484,{"v":1e-164,"d":"1.00E-164"},"Chondrolectin",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0010975|regulation of neuron projection development;GO:0050772|positive regulation of axonogenesis;","GO:0005737|cytoplasm;GO:0005813|centrosome;GO:0005829|cytosol;GO:0016021|integral component of membrane;GO:0048471|perinuclear region of cytoplasm;",".","K10078","CHODL; chondrolectin"]
["ENSRNOG00000010315",9,0.757217418,1,0.064330438,11.77074864,3.557134176,0.002418645,0.001743104,"up","yes","Ccr4","protein_coding","chr8:114176974-114178056:-","gi|149018350|gb|EDL76991.1|",1740,0,"rCG25460 [Rattus norvegicus]","gi|672063364|ref|XM_006243915.2|",1083,0,"PREDICTED: Rattus norvegicus chemokine (C-C motif) receptor 4 (Ccr4), transcript variant X1, mRNA","P51680",654,0,"C-C chemokine receptor type 4",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001764|neuron migration;GO:0002507|tolerance induction;GO:0006935|chemotaxis;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0009314|response to radiation;GO:0009617|response to bacterium;GO:0019722|calcium-mediated signaling;GO:0046677|response to antibiotic;GO:0048872|homeostasis of number of cells;GO:0050927|positive regulation of positive chemotaxis;GO:0060326|cell chemotaxis;GO:0070098|chemokine-mediated signaling pathway;","GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0043025|neuronal cell body;","GO:0003674|molecular_function;GO:0016493|C-C chemokine receptor activity;GO:0019957|C-C chemokine binding;","K04179","CCR4, CD194; C-C chemokine receptor type 4"]
["ENSRNOG00000023030",9,0.757217418,1,0.064330438,11.77074864,3.557134176,0.002418645,0.001743104,"up","yes","Cd96","protein_coding","chr11:54702290-54776621:+","gi|68163543|ref|NP_001020203.1|",3022,0,"T-cell surface protein tactile precursor [Rattus norvegicus]","gi|68163542|ref|NM_001025032.1|",2053,0,"Rattus norvegicus CD96 molecule (Cd96), mRNA","Q5BK49",1172,0,"T-cell surface protein tactile",".",".",".",".","pfam08205","C2-set_2","CD80-like C2-set immunoglobulin domain. These domains belong to the immunoglobulin superfamily.","GO:0002728|negative regulation of natural killer cell cytokine production;GO:0006954|inflammatory response;GO:0007160|cell-matrix adhesion;GO:0032496|response to lipopolysaccharide;GO:0032689|negative regulation of interferon-gamma production;","GO:0005737|cytoplasm;GO:0016021|integral component of membrane;",".","K06517","CD96; CD96 antigen"]
["ENSRNOG00000029637",9,0.757217418,1,0.064330438,11.77074864,3.557134176,0.002418645,0.001743104,"up","yes","Acot6","protein_coding","chr6:103732372-103741446:+","gi|765826426|ref|NP_001292214.1|",2068,0,"acyl-coenzyme A thioesterase 6 [Rattus norvegicus]","gi|765826425|ref|NM_001305285.1|",1578,0,"Rattus norvegicus acyl-CoA thioesterase 6 (Acot6), mRNA","Q32Q92",668,0,"Acyl-coenzyme A thioesterase 6","RSc1887_1",137,{"v":1e-34,"d":"1.00E-34"},"COG1073","pfam08840","BAAT_C","BAAT / Acyl-CoA thioester hydrolase C terminal. This catalytic domain is found at the C terminal of acyl-CoA thioester hydrolases and bile acid-CoA:amino acid N-acetyltransferases (BAAT).","GO:0006631|fatty acid metabolic process;GO:0006637|acyl-CoA metabolic process;","GO:0005829|cytosol;","GO:0047617|acyl-CoA hydrolase activity;","K11993","ACOT6; acyl-CoA thioesterase 6 [EC:3.1.2.-]"]
["ENSRNOG00000042140",9,0.757217418,1,0.064330438,11.77074864,3.557134176,0.002418645,0.001743104,"up","yes","Eomes","protein_coding","chr8:118181777-118188316:+","gi|148677303|gb|EDL09250.1|",2908,0,"eomesodermin homolog (Xenopus laevis), isoform CRA_a, partial [Mus musculus]","gi|258645097|ref|NM_010136.3|",1903,0,"Mus musculus eomesodermin (Eomes), transcript variant 1, mRNA","O54839",1102,0,"Eomesodermin homolog",".",".",".",".","pfam00907","T-box","T-box. The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001706|endoderm formation;GO:0001707|mesoderm formation;GO:0001714|endodermal cell fate specification;GO:0001824|blastocyst development;GO:0001829|trophectodermal cell differentiation;GO:0002302|CD8-positive, alpha-beta T cell differentiation involved in immune response;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007420|brain development;GO:0007492|endoderm development;GO:0009653|anatomical structure morphogenesis;GO:0010002|cardioblast differentiation;GO:0010468|regulation of gene expression;GO:0019827|stem cell population maintenance;GO:0021772|olfactory bulb development;GO:0021796|cerebral cortex regionalization;GO:0021895|cerebral cortex neuron differentiation;GO:0022008|neurogenesis;GO:0030154|cell differentiation;GO:0030182|neuron differentiation;GO:0035914|skeletal muscle cell differentiation;GO:0043433|negative regulation of DNA-binding transcription factor activity;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048382|mesendoderm development;GO:0060706|cell differentiation involved in embryonic placenta development;GO:0060809|mesodermal to mesenchymal transition involved in gastrulation;","GO:0000785|chromatin;GO:0005634|nucleus;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0003682|chromatin binding;GO:0043565|sequence-specific DNA binding;GO:0061629|RNA polymerase II sequence-specific DNA-binding transcription factor binding;GO:1990837|sequence-specific double-stranded DNA binding;","K10173","EOMES, TBR2; eomesodermin protein"]
["ENSRNOG00000066355",9,0.757217418,1,0.064330438,11.77074864,3.557134176,0.002418645,0.001743104,"up","yes","ENSRNOG00000066355","lncRNA","chr1:38662883-38683131:-","gi|672072106|ref|XP_006248795.2|",581,{"v":2e-96,"d":"2.00E-96"},"PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC302022 isoform X1 [Rattus norvegicus]","gi|672021287|ref|XR_601634.1|",2641,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103695335 (LOC103695335), ncRNA","B5DFC9",197,{"v":4e-80,"d":"4.00E-80"},"Nidogen-2",".",".",".",".","pfam02948","Amelogenin","Amelogenin. Amelogenins play a role in biomineralisation. They seem to regulate the formation of crystallites during the secretory stage of tooth enamel development. thought to play a major role in the structural organisation and mineralisation of developing enamel. They are found in the extracellular matrix. Mutations in X-chromosomal amelogenin can cause Amelogenesis imperfecta.",".",".",".",".","."]
["ENSRNOG00000066977",9,0.757217418,1,0.064330438,11.77074864,3.557134176,0.002418645,0.001743104,"up","yes","ENSRNOG00000066977","protein_coding","chr8:108236754-108241065:-","gi|148689252|gb|EDL21199.1|",462,{"v":4E-51,"d":"4.00E-51"},"mCG146219, partial [Mus musculus]","gi|672023321|ref|XR_348734.2|",958,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102551360 (LOC102551360), transcript variant X2, ncRNA","Q9WVF8",69.7,{"v":1e-12,"d":"1.00E-12"},"Tumor suppressor candidate 2",".",".",".",".","pfam15000","TUSC2","tumor suppressor candidate 2. This family of proteins are candidate tumor suppressors.",".",".",".",".","."]
["ENSRNOG00000067434",9,0.757217418,1,0.064330438,11.77074864,3.557134176,0.002418645,0.001743104,"up","yes","Hist1h2an","protein_coding","chr17:41534691-41539869:+","gi|671000624|ref|XP_008691171.1|",548,{"v":4e-61,"d":"4.00E-61"},"PREDICTED: histone H2A type 1-like [Ursus maritimus]","gi|46064034|gb|AC034285.6|",629,0,"Mus musculus chromosome 13, clone RP23-220G21, complete sequence","C0HKE9",215,{"v":2e-62,"d":"2.00E-62"},"Histone H2A type 1-P","SPAC19G12.06c",178,{"v":3e-50,"d":"3.00E-50"},"COG5262","pfam00125","Histone","Core histone H2A/H2B/H3/H4.",".",".",".",".","."]
["ENSRNOG00000068685",9,0.757217418,1,0.064330438,11.77074864,3.557134176,0.002418645,0.001743104,"up","yes","Klk1c2","protein_coding","chr1:94492332-94496481:-","gi|6981670|ref|NP_036809.1|",1383,0,"tonin precursor [Rattus norvegicus]","gi|6981669|ref|NM_012677.1|",855,0,"Rattus norvegicus kallikrein 1-related peptidase C2 (Klk1c2), mRNA","P00759",537,0,"Tonin","mlr3307",95.9,{"v":5e-22,"d":"5.00E-22"},"COG5640","pfam00089","Trypsin","Trypsin.",".",".",".",".","."]
["ENSRNOG00000070399",9,0.757217418,1,0.064330438,11.77074864,3.557134176,0.002418645,0.001743104,"up","yes","ENSRNOG00000070399","protein_coding","chr2:231643535-231741152:-","gi|564301078|ref|XP_003753729.2|",2638,0,"PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC685116 isoform X1 [Rattus norvegicus]","gi|672016482|ref|XM_008775292.1|",1300,0,"PREDICTED: Rattus norvegicus similar to guanylate binding protein family, member 6 (LOC687532), transcript variant X1, mRNA","Q61107",729,0,"Guanylate-binding protein 4",".",".",".",".","pfam02841","GBP_C","Guanylate-binding protein, C-terminal domain. Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.",".",".",".",".","."]
["ENSRNOG00000007012",45,3.786087089,29,1.865582707,2.029439421,1.021081276,0.00251521,0.001809823,"up","yes","Ly75","protein_coding","chr3:44765122-44852374:-","gi|564301698|ref|XP_006224510.1|",9264,0,"PREDICTED: lymphocyte antigen 75 [Rattus norvegicus]","gi|672045718|ref|XM_006234242.2|",6498,0,"PREDICTED: Rattus norvegicus lymphocyte antigen 75 (Ly75), mRNA","Q60767",3208,0,"Lymphocyte antigen 75",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0006897|endocytosis;","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0030246|carbohydrate binding;GO:0038023|signaling receptor activity;","K06559","LY75, CD205; lymphocyte antigen 75"]
["ENSRNOG00000001684",36,3.028869671,21,1.350939202,2.24204736,1.164816753,0.002637499,1.891567E-3,"up","yes","Ripply3","protein_coding","chr11:33648486-33656584:+","gi|157786836|ref|NP_001099362.1|",571,{"v":6E-68,"d":"6.00E-68"},"protein ripply3 [Rattus norvegicus]","gi|157786835|ref|NM_001105892.1|",1421,0,"Rattus norvegicus ripply transcriptional repressor 3 (Ripply3), mRNA","Q924S9",208,{"v":4e-63,"d":"4.00E-63"},"Protein ripply3",".",".",".",".","pfam14998","Ripply","Transcription Regulator. The precise function of this family is not clear, but it is thought to play a role in somitogenesis, development and transcriptional repression. Ripply is also known by an alternative name, Bowline. Bowline, is an associate protein of the transcriptional co-repressor XGrg-4. This family contains two conserved sequence motifs: WRPW and FPVQATI. The WRPW motif is thought to be required for binding to tle/groucho proteins. Ripply3 is also known as Down Syndrome Critical Region Protein 6 homolog. This family of proteins is found in eukaryotes. Proteins in this family are typically between 109 and 154 amino acids in length.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0007507|heart development;GO:0008285|negative regulation of cell proliferation;GO:0009880|embryonic pattern specification;GO:0060037|pharyngeal system development;","GO:0005634|nucleus;",".",".","."]
["ENSRNOG00000002834",24,2.019246448,11,0.70763482,2.853514822,1.512740057,0.002681223,1.920143E-3,"up","yes","Klb","protein_coding","chr14:42899510-42950799:-","gi|13626032|ref|NP_112457.1|",5233,0,"beta-klotho [Mus musculus]","gi|118130737|ref|NM_031180.2|",2671,0,"Mus musculus klotho beta (Klb), mRNA","Q99N32",2020,0,"Beta-klotho","BH1923",232,{"v":4e-65,"d":"4.00E-65"},"COG2723","pfam00232","Glyco_hydro_1","Glycosyl hydrolase family 1.",".",".",".",".","."]
["ENSRNOG00000057691",20,1.682705373,8,0.514643505,3.2696524,1.70913727,0.002764974,0.001975444,"up","yes","AC112557.1","lncRNA","chr8:44571409-44574866:+","gi|625279353|ref|XP_007631318.1|",174,{"v":3E-10,"d":"3.00E-10"},"PREDICTED: E3 ubiquitin-protein ligase CBL isoform X2 [Cricetulus griseus]","gi|672022727|ref|XR_348451.2|",1189,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102547566 (LOC102547566), ncRNA",".",".",".",".",".",".",".",".","pfam04817","Umbravirus_LDM","Umbravirus long distance movement (LDM) family. The long distance movement protein of Umbraviruses mediates the movement of viral RNA through the phloem of infected plants.",".",".",".",".","."]
["ENSRNOG00000066547",20,1.682705373,8,0.514643505,3.2696524,1.70913727,0.002764974,0.001975444,"up","yes","ENSRNOG00000066547","protein_coding","chr1:159151432-159155192:+","gi|672089543|ref|XP_008772019.1|",2525,0,"PREDICTED: ubiquitin carboxyl-terminal hydrolase 17-like protein A isoform X2 [Rattus norvegicus]","gi|672089542|ref|XM_008773797.1|",1492,0,"PREDICTED: Rattus norvegicus similar to ubiquitin specific peptidase 17 (homolog) (LOC689730), transcript variant X2, mRNA","Q7M764",664,0,"Ubiquitin carboxyl-terminal hydrolase 17-like protein E",".",".",".",".","pfam00443","UCH","Ubiquitin carboxyl-terminal hydrolase.",".",".",".",".","."]
["ENSRNOG00000070411",20,1.682705373,8,0.514643505,3.2696524,1.70913727,0.002764974,0.001975444,"up","yes","ENSRNOG00000070411","lncRNA","chr3:65274032-65275043:-","gi|149066508|gb|EDM16381.1|",194,{"v":6e-16,"d":"6.00E-16"},"rCG63686 [Rattus norvegicus]","gi|163943533|gb|AC096430.6|",138,{"v":6e-64,"d":"6.00E-64"},"Rattus norvegicus BAC CH230-155O11 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam10243","MIP-T3","Microtubule-binding protein MIP-T3. This protein, which interacts with both microtubules and TRAF3 (tumor necrosis factor receptor-associated factor 3), is conserved from worms to humans. The N-terminal region is the microtubule binding domain and is well-conserved; the C-terminal 100 residues, also well-conserved, constitute the coiled-coil region which binds to TRAF3. The central region of the protein is rich in lysine and glutamic acid and carries KKE motifs which may also be necessary for tubulin-binding, but this region is the least well-conserved.",".",".",".",".","."]
["ENSRNOG00000045913",37,3.11300494,22,1.41526964,2.199584342,1.137230922,2.783874E-3,0.001988425,"up","yes","Prdm16","protein_coding","chr5:164880587-165203601:-","gi|597517970|ref|NP_001277958.1|",5281,0,"PR domain zinc finger protein 16 isoform 4 [Mus musculus]","gi|672020256|ref|XM_008776149.1|",4134,0,"PREDICTED: Rattus norvegicus PR domain containing 16 (Prdm16), transcript variant X1, mRNA","A2A935",2024,0,"PR domain zinc finger protein 16",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008150|biological_process;GO:0019827|stem cell population maintenance;GO:0022008|neurogenesis;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030853|negative regulation of granulocyte differentiation;GO:0035019|somatic stem cell population maintenance;GO:0043457|regulation of cellular respiration;GO:0043586|tongue development;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050872|white fat cell differentiation;GO:0050873|brown fat cell differentiation;GO:0051567|histone H3-K9 methylation;GO:0060021|roof of mouth development;GO:0070828|heterochromatin organization;GO:0090336|positive regulation of brown fat cell differentiation;GO:0120162|positive regulation of cold-induced thermogenesis;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;GO:0016235|aggresome;GO:0017053|transcriptional repressor complex;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003712|transcription coregulator activity;GO:0003713|transcription coactivator activity;GO:0043565|sequence-specific DNA binding;GO:0046332|SMAD binding;GO:0046974|histone methyltransferase activity (H3-K9 specific);","K22410","PRDM16; [histone H3]-lysine9 N-methyltransferase [EC:2.1.1.367]"]
["ENSRNOG00000067159",30,2.524058059,16,1.029287011,2.4522393,1.29409977,0.002861751,0.002038968,"up","yes","ENSRNOG00000067159","pseudogene","chr6:87354410-87354688:-","gi|451770396|ref|NP_001263412.1|",398,{"v":3e-48,"d":"3.00E-48"},"small integral membrane protein 12 [Rattus norvegicus]","gi|672053852|ref|XM_006238907.2|",156,{"v":1e-74,"d":"1.00E-74"},"PREDICTED: Rattus norvegicus small integral membrane protein 12 (Smim12), transcript variant X1, mRNA","D4ACP2",157,{"v":1e-49,"d":"1.00E-49"},"Small integral membrane protein 12",".",".",".",".","pfam03169","OPT","OPT oligopeptide transporter protein. The OPT family of oligopeptide transporters is distinct from the ABC pfam00005 and PTR pfam00854 transporter families. OPT transporters were first recognized in fungi (Candida albicans and Schizosaccharomyces pombe), but this alignment also includes orthologues from Arabidopsis thaliana. OPT transporters are thought to have 12-14 transmembrane domains and contain the following motif: SPYxEVRxxVxxxDDP.",".",".",".",".","."]
["ENSRNOG00000016756",38,3.197140209,23,1.479600078,2.16081376,1.111574732,0.002924007,0.002078701,"up","yes","Ptgir","protein_coding","chr1:77579596-77581979:+","gi|117647216|ref|NP_001071112.1|",2044,0,"prostacyclin receptor [Rattus norvegicus]","gi|117647215|ref|NM_001077644.1|",1360,0,"Rattus norvegicus prostaglandin I2 (prostacyclin) receptor (IP) (Ptgir), mRNA","P43253",791,0,"Prostacyclin receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0006954|inflammatory response;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0010642|negative regulation of platelet-derived growth factor receptor signaling pathway;GO:0032496|response to lipopolysaccharide;GO:0048662|negative regulation of smooth muscle cell proliferation;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0016501|prostacyclin receptor activity;","K04263","PTGIR; prostacyclin receptor"]
["ENSRNOG00000007364",25,2.103381716,12,0.771965258,2.724710333,1.446102864,3.046024E-3,2.159523E-3,"up","yes","Rab15","protein_coding","chr6:95499587-95523942:-","gi|38454238|ref|NP_942044.1|",1063,{"v":3e-133,"d":"3.00E-133"},"ras-related protein Rab-15 [Rattus norvegicus]","gi|66955887|ref|NM_198749.2|",3388,0,"Rattus norvegicus RAB15, member RAS oncogene family (Rab15), mRNA","P35289",414,{"v":1E-134,"d":"1.00E-134"},"Ras-related protein Rab-15",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0006904|vesicle docking involved in exocytosis;GO:0007269|neurotransmitter secretion;GO:0009306|protein secretion;GO:0017157|regulation of exocytosis;GO:0032482|Rab protein signal transduction;GO:0032869|cellular response to insulin stimulus;GO:0072659|protein localization to plasma membrane;GO:1903307|positive regulation of regulated secretory pathway;","GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005929|cilium;GO:0008021|synaptic vesicle;GO:0010008|endosome membrane;GO:0016020|membrane;GO:0032593|insulin-responsive compartment;GO:0048471|perinuclear region of cytoplasm;GO:0055037|recycling endosome;","GO:0003924|GTPase activity;GO:0005525|GTP binding;","K07908","RAB15; Ras-related protein Rab-15"]
["ENSRNOG00000014578",17,1.430299567,6,0.385982629,3.705606054,1.889709515,0.00310965,0.002201478,"up","yes","Fxyd4","protein_coding","chr4:151109779-151113637:-","gi|11693156|ref|NP_071783.1|",450,{"v":3E-51,"d":"3.00E-51"},"FXYD domain-containing ion transport regulator 4 precursor [Rattus norvegicus]","gi|11693155|ref|NM_022388.1|",1359,0,"Rattus norvegicus FXYD domain-containing ion transport regulator 4 (Fxyd4), mRNA","Q63113",177,{"v":1E-52,"d":"1.00E-52"},"FXYD domain-containing ion transport regulator 4",".",".",".",".","pfam02038","ATP1G1_PLM_MAT8","ATP1G1/PLM/MAT8 family.","GO:0071805|potassium ion transmembrane transport;GO:0098662|inorganic cation transmembrane transport;GO:2000649|regulation of sodium ion transmembrane transporter activity;","GO:0005890|sodium:potassium-exchanging ATPase complex;","GO:0005267|potassium channel activity;GO:0005515|protein binding;GO:0017080|sodium channel regulator activity;GO:0051117|ATPase binding;","K13359","FXYD4, CHIF; FXYD domain containing ion transport regulator 4"]
["ENSRNOG00000008449",14,1.177893761,4,0.257321753,4.57751336,2.194564097,0.003119952,0.002206888,"up","yes","Neurod4","protein_coding","chr7:7090045-7102030:-","gi|564357922|ref|XP_006240880.1|",1634,0,"PREDICTED: neurogenic differentiation factor 4 isoform X1 [Rattus norvegicus]","gi|157786953|ref|NM_001105942.1|",3285,0,"Rattus norvegicus neuronal differentiation 4 (Neurod4), mRNA","O09105",595,0,"Neurogenic differentiation factor 4",".",".",".",".","pfam12533","Neuro_bHLH","Neuronal helix-loop-helix transcription factor. This domain family is found in eukaryotes, and is approximately 80 amino acids in length. The family is found C-terminal to pfam00010. There is a single completely conserved residue W that may be functionally important. Neuronal basic helix-loop-helix (bHLH) transcription factors such as neuroD and neurogenin have been shown to play important roles in neuronal development.","GO:0001764|neuron migration;GO:0006357|regulation of transcription by RNA polymerase II;GO:0007219|Notch signaling pathway;GO:0007405|neuroblast proliferation;GO:0010001|glial cell differentiation;GO:0030182|neuron differentiation;GO:0035881|amacrine cell differentiation;GO:0043010|camera-type eye development;GO:0045165|cell fate commitment;GO:0045597|positive regulation of cell differentiation;GO:0048666|neuron development;GO:0060041|retina development in camera-type eye;","GO:0005575|cellular_component;GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0046983|protein dimerization activity;","K09079","NEUROD4, ATOH3, MATH3; neurogenic differentiation factor 4"]
["ENSRNOG00000028064",14,1.177893761,4,0.257321753,4.57751336,2.194564097,0.003119952,0.002206888,"up","yes","Fhad1","protein_coding","chr5:154191745-154310354:-","gi|564306380|ref|XP_006225653.1|",6881,0,"PREDICTED: forkhead-associated domain-containing protein 1 isoform X2 [Rattus norvegicus]","gi|672020065|ref|XM_006225591.2|",4635,0,"PREDICTED: Rattus norvegicus forkhead-associated (FHA) phosphopeptide binding domain 1 (Fhad1), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam02463","SMC_N","RecF/RecN/SMC N terminal domain. This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics.   This family also includes the RecF and RecN proteins that are involved in DNA metabolizm and recombination.",".",".",".",".","."]
["ENSRNOG00000029738",14,1.177893761,4,0.257321753,4.57751336,2.194564097,0.003119952,0.002206888,"up","yes","Diras1","protein_coding","chr7:8687942-8693831:+","gi|157823255|ref|NP_001102457.1|",1059,{"v":3E-134,"d":"3.00E-134"},"GTP-binding protein Di-Ras1 [Rattus norvegicus]","gi|157823254|ref|NM_001108987.1|",1897,0,"Rattus norvegicus DIRAS family, GTP-binding RAS-like 1 (Diras1), mRNA","Q91Z61",410,{"v":6e-135,"d":"6.00E-135"},"GTP-binding protein Di-Ras1",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0007165|signal transduction;","GO:0005886|plasma membrane;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0019003|GDP binding;","K07840","DIRAS1; DIRAS family, GTP-binding Ras-like 1"]
["ENSRNOG00000069978",14,1.177893761,4,0.257321753,4.57751336,2.194564097,0.003119952,0.002206888,"up","yes","ENSRNOG00000069978","lncRNA","chr10:44167681-44185997:+",".",".",".",".","gi|672024823|ref|XR_338639.2|",785,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102546363 (LOC102546363), transcript variant X3, ncRNA",".",".",".",".",".",".",".",".","pfam03040","CemA","CemA family. Members of this family are probable integral membrane proteins. Their molecular function is unknown. CemA proteins are found in the inner envelope membrane of chloroplasts but not in the thylakoid membrane. A cyanobacterial member of this family has been implicated in CO2 transport, but is probably not a CO2 transporter itself. They are predicted to be haem-binding however this has not been proven experimentally.",".",".",".",".","."]
["ENSRNOG00000011202",41,3.449546015,26,1.672591393,2.062396129,1.044321461,0.003304659,0.002324723,"up","yes","Chrna4","protein_coding","chr3:168136266-168156957:-","gi|149033985|gb|EDL88768.1|",2994,0,"cholinergic receptor, nicotinic, alpha polypeptide 4, isoform CRA_a [Rattus norvegicus]","gi|31418503|gb|BC053013.1|",2868,0,"Mus musculus cholinergic receptor, nicotinic, alpha polypeptide 4, mRNA (cDNA clone MGC:62206 IMAGE:5706867), complete cds","P09483",1146,0,"Neuronal acetylcholine receptor subunit alpha-4",".",".",".",".","pfam02931","Neur_chan_LBD","Neurotransmitter-gated ion-channel ligand binding domain. This family is the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.","GO:0001508|action potential;GO:0001666|response to hypoxia;GO:0006281|DNA repair;GO:0006816|calcium ion transport;GO:0006979|response to oxidative stress;GO:0007165|signal transduction;GO:0007268|chemical synaptic transmission;GO:0007271|synaptic transmission, cholinergic;GO:0007585|respiratory gaseous exchange;GO:0007626|locomotory behavior;GO:0014059|regulation of dopamine secretion;GO:0019233|sensory perception of pain;GO:0034220|ion transmembrane transport;GO:0035094|response to nicotine;GO:0035095|behavioral response to nicotine;GO:0035640|exploration behavior;GO:0042113|B cell activation;GO:0042391|regulation of membrane potential;GO:0050877|nervous system process;GO:0050890|cognition;GO:0051899|membrane depolarization;GO:0060079|excitatory postsynaptic potential;GO:0060080|inhibitory postsynaptic potential;GO:0095500|acetylcholine receptor signaling pathway;GO:1903048|regulation of acetylcholine-gated cation channel activity;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005892|acetylcholine-gated channel complex;GO:0009897|external side of plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0032991|protein-containing complex;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0045202|synapse;GO:0045211|postsynaptic membrane;GO:0098691|dopaminergic synapse;GO:0098981|cholinergic synapse;GO:0099056|integral component of presynaptic membrane;GO:0099060|integral component of postsynaptic specialization membrane;","GO:0004888|transmembrane signaling receptor activity;GO:0005216|ion channel activity;GO:0005515|protein binding;GO:0015464|acetylcholine receptor activity;GO:0022848|acetylcholine-gated cation-selective channel activity;GO:0030594|neurotransmitter receptor activity;GO:0042166|acetylcholine binding;GO:0044877|protein-containing complex binding;GO:1904315|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K04806","CHRNA4; nicotinic acetylcholine receptor alpha-4"]
["ENSRNOG00000013465",32,2.692328597,18,1.157947887,2.325086151,1.217284173,0.003324611,2.337249E-3,"up","yes","Tepp","protein_coding","chr19:9712641-9722257:-","gi|672084062|ref|XP_008770496.1|",1184,{"v":5e-157,"d":"5.00E-157"},"PREDICTED: testis, prostate and placenta-expressed protein isoform X1 [Rattus norvegicus]","gi|672084061|ref|XM_008772274.1|",910,0,"PREDICTED: Rattus norvegicus testis, prostate and placenta expressed (Tepp), transcript variant X1, mRNA","Q6IMG9",325,{"v":5e-109,"d":"5.00E-109"},"Testis, prostate and placenta-expressed protein",".",".",".",".","pfam05283","MGC-24","Multi-glycosylated core protein 24 (MGC-24). This family consists of several MGC-24 (or Cd164 antigen) proteins from eukaryotic organisms. MGC-24/CD164 is a sialomucin expressed in many normal and cancerous tissues. In humans, soluble and transmembrane forms of MGC-24 are produced by alternative splicing.","GO:0019953|sexual reproduction;",".",".",".","."]
["ENSRNOG00000071079",26,2.187516985,13,0.836295696,2.61572192,1.387209175,0.003407047,0.002387189,"up","yes","ENSRNOG00000071079","lncRNA","chr8:79290513-79292772:+","gi|432101292|gb|ELK29518.1|",101,{"v":2e-06,"d":"2.00E-06"},"hypothetical protein MDA_GLEAN10005688 [Myotis davidii]","gi|74222279|dbj|AK146160.1|",115,{"v":3E-51,"d":"3.00E-51"},"Mus musculus TIB-55 BB88 cDNA, RIKEN full-length enriched library, clone:I730025B03 product:unclassifiable, full insert sequence","Q3UTZ3",43.9,{"v":7e-08,"d":"7.00E-08"},"Uncharacterized protein C7orf43 homolog",".",".",".",".","pfam03616","Glt_symporter","Sodium/glutamate symporter.",".",".",".",".","."]
["ENSRNOG00000013793",42,3.533681283,27,1.736921831,2.034450382,1.024639095,0.003417901,0.002393562,"up","yes","C1qtnf9","protein_coding","chr15:34911286-34922980:+","gi|564386546|ref|XP_006252196.1|",1452,0,"PREDICTED: C1q and tumor necrosis factor related protein 9 isoform X1 [Rattus norvegicus]","gi|672078346|ref|XM_006252134.2|",1214,0,"PREDICTED: Rattus norvegicus C1q and tumor necrosis factor related protein 9 (C1qtnf9), transcript variant X1, mRNA","Q4ZJN1",523,0,"Complement C1q and tumor necrosis factor-related protein 9",".",".",".",".","pfam00386","C1q","C1q domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.","GO:0007165|signal transduction;GO:0019395|fatty acid oxidation;GO:0045792|negative regulation of cell size;GO:0071902|positive regulation of protein serine/threonine kinase activity;GO:0097009|energy homeostasis;GO:1900078|positive regulation of cellular response to insulin stimulus;","GO:0005615|extracellular space;","GO:0005179|hormone activity;GO:0042802|identical protein binding;","K24213","C1QTNF9; complement C1q and tumor necrosis factor-related protein 9"]
["ENSRNOG00000037275",42,3.533681283,27,1.736921831,2.034450382,1.024639095,0.003417901,0.002393562,"up","yes","Tlcd2","protein_coding","chr10:60311099-60313622:+","gi|392331811|ref|XP_001080690.3|",1158,{"v":2e-156,"d":"2.00E-156"},"PREDICTED: TLC domain-containing protein 2 isoform X1 [Rattus norvegicus]","gi|672024947|ref|XM_001080690.5|",944,0,"PREDICTED: Rattus norvegicus TLC domain containing 2 (Tlcd2), transcript variant X1, mRNA","Q8VC26",364,{"v":1e-123,"d":"1.00E-123"},"TLC domain-containing protein 2",".",".",".",".","pfam03798","TRAM_LAG1_CLN8","TLC domain.","GO:0007009|plasma membrane organization;GO:0055088|lipid homeostasis;GO:0055091|phospholipid homeostasis;GO:0071709|membrane assembly;GO:0097035|regulation of membrane lipid distribution;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000027295",34,2.860599134,20,1.286608764,2.223363632,1.152743921,0.003753749,2.606962E-3,"up","yes","Aph1b","protein_coding","chr8:67429198-67450243:-","gi|114053317|ref|NP_001040555.1|",1133,{"v":2e-151,"d":"2.00E-151"},"gamma-secretase subunit APH-1B [Rattus norvegicus]","gi|672062505|ref|XM_008766401.1|",1279,0,"PREDICTED: Rattus norvegicus gamma-secretase subunit APH-1B-like (LOC100911293), mRNA","Q8C7N7",421,{"v":3e-145,"d":"3.00E-145"},"Gamma-secretase subunit APH-1B",".",".",".",".","pfam06105","Aph-1","Aph-1 protein. This family consists of several eukaryotic Aph-1 proteins.Gamma-secretase catalyses the intramembrane proteolysis of Notch, beta-amyloid precursor protein, and other substrates as part of a new signaling paradigm and as a key step in the pathogenesis of Alzheimer's disease. It is thought that the presenilin heterodimer comprises the catalytic site and that a highly glycosylated form of nicastrin associates with it. Aph-1 and Pen-2, two membrane proteins genetically linked to gamma-secretase, associate directly with presenilin and nicastrin in the active protease complex. Co-expression of all four proteins leads to marked increases in presenilin heterodimers, full glycosylation of nicastrin, and enhanced gamma-secretase activity.","GO:0001963|synaptic transmission, dopaminergic;GO:0006509|membrane protein ectodomain proteolysis;GO:0007219|Notch signaling pathway;GO:0007220|Notch receptor processing;GO:0007614|short-term memory;GO:0007626|locomotory behavior;GO:0010950|positive regulation of endopeptidase activity;GO:0016485|protein processing;GO:0034205|amyloid-beta formation;GO:0035249|synaptic transmission, glutamatergic;GO:0042987|amyloid precursor protein catabolic process;GO:0060134|prepulse inhibition;","GO:0005575|cellular_component;GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;GO:0030133|transport vesicle;GO:0045202|synapse;GO:0070765|gamma-secretase complex;","GO:0003674|molecular_function;GO:0030674|protein binding, bridging;GO:0061133|endopeptidase activator activity;","K06172","APH1; gamma-secretase subunit APH-1"]
["ENSRNOG00000022710",27,2.271652253,14,0.900626135,2.52230328,1.334741755,0.003760941,0.002611624,"up","yes","Prrg4","protein_coding","chr3:91214653-91243273:-","gi|157822375|ref|NP_001102673.1|",1011,{"v":7e-130,"d":"7.00E-130"},"transmembrane gamma-carboxyglutamic acid protein 4 precursor [Rattus norvegicus]","gi|157822374|ref|NM_001109203.1|",1331,0,"Rattus norvegicus proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) (Prrg4), mRNA","Q8BGN6",355,{"v":2E-116,"d":"2.00E-116"},"Transmembrane gamma-carboxyglutamic acid protein 4",".",".",".",".","pfam00594","Gla","Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain. This domain is responsible for the high-affinity binding of calcium ions. This domain contains post-translational modifications of many glutamate residues by Vitamin K-dependent carboxylation to form gamma-carboxyglutamate (Gla).",".","GO:0005576|extracellular region;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0005509|calcium ion binding;GO:0050699|WW domain binding;",".","."]
["ENSRNOG00000063741",18,1.514434836,7,0.450313067,3.36307104,1.749779254,0.003898457,0.002694744,"up","yes","ENSRNOG00000063741","protein_coding","chr5:57703909-57723062:+","gi|672019262|ref|XP_008774163.1|",185,{"v":1e-12,"d":"1.00E-12"},"PREDICTED: prothymosin alpha-like [Rattus norvegicus]","gi|672019261|ref|XM_008775941.1|",2635,0,"PREDICTED: Rattus norvegicus RGD1560723 (RGD1560723), mRNA",".",".",".",".",".",".",".",".","pfam00607","Gag_p24","gag gene protein p24 (core nucleocapsid protein). p24 forms inner protein layer of the nucleocapsid. ELISA tests for p24 is the most commonly used method to demonstrate virus replication both in vivo and in vitro.",".",".",".",".","."]
["ENSRNOG00000069103",18,1.514434836,7,0.450313067,3.36307104,1.749779254,0.003898457,0.002694744,"up","yes","ENSRNOG00000069103","lncRNA","chr4:182367222-182395525:+",".",".",".",".","gi|49615119|gb|AC113720.6|",169,{"v":2e-81,"d":"2.00E-81"},"Rattus norvegicus 1 BAC CH230-117B1 (Children's Hospital Oakland Research Institute) complete sequence",".",".",".",".",".",".",".",".","pfam12091","DUF3567","Protein of unknown function (DUF3567). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are about 90 amino acids in length. This protein has a conserved EIVDK sequence motif.",".",".",".",".","."]
["ENSRNOG00000017986",35,2.944734403,21,1.350939202,2.179768267,1.124174769,0.003953927,0.002731353,"up","yes","Zfp458","protein_coding","chr2:84693186-84702558:+","gi|219282679|ref|NP_001136434.1|",3897,0,"zinc finger protein 458 isoform 1 [Rattus norvegicus]","gi|66730326|ref|NM_001024299.1|",3265,0,"Rattus norvegicus zinc finger protein 458 (Zfp458), transcript variant 2, mRNA","Q6P5C7",1270,0,"Zinc finger protein 728",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0045944|positive regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0046872|metal ion binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["ENSRNOG00000019118",12,1.009623224,3,0.192991315,5.23144384,2.387209175,0.00399069,0.002752209,"up","yes","Slc13a3","protein_coding","chr3:154141872-154204606:-","gi|162138928|ref|NP_074057.2|",2561,0,"solute carrier family 13 member 3 [Rattus norvegicus]","gi|162138927|ref|NM_022866.2|",3176,0,"Rattus norvegicus solute carrier family 13 member 3 (Slc13a3), mRNA","Q9Z0Z5",988,0,"Solute carrier family 13 member 3","SA1732",204,{"v":4E-55,"d":"4.00E-55"},"COG0471","pfam00939","Na_sulph_symp","Sodium:sulfate symporter transmembrane region. There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.","GO:0006814|sodium ion transport;GO:0006835|dicarboxylic acid transport;GO:0015742|alpha-ketoglutarate transport;GO:0015744|succinate transport;GO:0015746|citrate transport;GO:0015810|aspartate transmembrane transport;GO:0034775|glutathione transmembrane transport;GO:0070778|L-aspartate transmembrane transport;GO:0071422|succinate transmembrane transport;GO:0098656|anion transmembrane transport;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;","GO:0005310|dicarboxylic acid transmembrane transporter activity;GO:0005343|organic acid:sodium symporter activity;GO:0015137|citrate transmembrane transporter activity;GO:0015139|alpha-ketoglutarate transmembrane transporter activity;GO:0015141|succinate transmembrane transporter activity;GO:0015183|L-aspartate transmembrane transporter activity;GO:0015362|high-affinity sodium:dicarboxylate symporter activity;GO:0017153|sodium:dicarboxylate symporter activity;GO:0034634|glutathione transmembrane transporter activity;","K14445","SLC13A2_3_5; solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2/3/5"]
["ENSRNOG00000019857",12,1.009623224,3,0.192991315,5.23144384,2.387209175,0.00399069,0.002752209,"up","yes","ENSRNOG00000019857","lncRNA","chr7:8697521-8761240:+","gi|149034469|gb|EDL89206.1|",594,{"v":1e-67,"d":"1.00E-67"},"guanine nucleotide binding protein, gamma 7, isoform CRA_a [Rattus norvegicus]","gi|298891051|emb|FQ211653.1|",2997,0,"Rattus norvegicus TL0AAA84YH22 mRNA sequence","P43425",139,{"v":8e-37,"d":"8.00E-37"},"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7",".",".",".",".","pfam00631","G-gamma","GGL domain. G-protein gamma like domains (GGL) are found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling (RGS) proteins. It is also found fused to an inactive Galpha in the Dictyostelium protein gbqA. G-gamma likely shares a common origin with the helical N-terminal unit of G-beta. All organisms that posses a G-beta possess a G-gamma.","GO:0001662|behavioral fear response;GO:0007168|receptor guanylyl cyclase signaling pathway;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007626|locomotory behavior;GO:0008150|biological_process;GO:0045761|regulation of adenylate cyclase activity;","GO:0005834|heterotrimeric G-protein complex;","GO:0003674|molecular_function;GO:0031681|G-protein beta-subunit binding;","K04543","GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7"]
["ENSRNOG00000026585",12,1.009623224,3,0.192991315,5.23144384,2.387209175,0.00399069,0.002752209,"up","yes","Lrrc66","protein_coding","chr14:34581240-34604541:+","gi|56912245|ref|NP_001008763.1|",4370,0,"leucine-rich repeat-containing protein 66 [Rattus norvegicus]","gi|672076111|ref|XM_008770138.1|",2601,0,"PREDICTED: Rattus norvegicus leucine rich repeat containing 66 (Lrrc66), transcript variant X1, mRNA","Q6TXF5",1687,0,"Leucine-rich repeat-containing protein 66",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.",".","GO:0005615|extracellular space;GO:0016021|integral component of membrane;GO:0031012|extracellular matrix;",".",".","."]
["ENSRNOG00000054431",12,1.009623224,3,0.192991315,5.23144384,2.387209175,0.00399069,0.002752209,"up","yes","U1","snRNA","chr10:4481565-4481724:+",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","pfam13901","DUF4206","Domain of unknown function (DUF4206). This is a family of cysteine-rich proteins. Many members also carry a pleckstrin-homology domain, pfam00169",".",".",".",".","."]
["ENSRNOG00000054975",12,1.009623224,3,0.192991315,5.23144384,2.387209175,0.00399069,0.002752209,"up","yes","U7","snRNA","chr4:157552861-157552922:-",".",".",".",".","gi|672064563|ref|XM_006244638.2|",62,{"v":3E-23,"d":"3.00E-23"},"PREDICTED: Rattus norvegicus protein C10-like (LOC100911713), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam15308","CEP170_C","CEP170 C-terminus. This family includes the C-terminus of centrosomal protein of 170 kDa (CEP170).",".",".",".",".","."]
["ENSRNOG00000018631",15,1.26202903,5,0.321652191,3.92358288,1.972171675,0.004271359,2.930925E-3,"up","yes","Enkur","protein_coding","chr17:83690797-83714408:-","gi|157817252|ref|NP_001099596.1|",1106,{"v":9e-148,"d":"9.00E-148"},"enkurin [Rattus norvegicus]","gi|157817251|ref|NM_001106126.1|",1205,0,"Rattus norvegicus enkurin, TRPC channel interacting protein (Enkur), mRNA","Q6SP97",393,{"v":1E-134,"d":"1.00E-134"},"Enkurin",".",".",".",".","pfam13864","Enkurin","Calmodulin-binding. This is a family of apparent calmodulin-binding proteins found at high levels in the testis and vomeronasal organ and at lower levels in certain other tissues. Enkurin is a scaffold protein that binds PI3 kinase to sperm transient receptor potential (canonical) (TRPC) channels. The mammalian transient receptor potential (canonical) channels are the primary candidates for the Ca(2+) entry pathway activated by the hormones, growth factors, and neurotransmitters that exert their effect through activation of PLC. Calmodulin binds to the C-terminus of all TRPC channels, and dissociation of calmodulin from TRPC4 results in profound activation of the channel.","GO:0030317|flagellated sperm motility;GO:0061966|establishment of left/right asymmetry;","GO:0001669|acrosomal vesicle;GO:0036126|sperm flagellum;GO:0097228|sperm principal piece;GO:0097728|9+0 motile cilium;GO:0097729|9+2 motile cilium;","GO:0005516|calmodulin binding;","K25647","ENKUR; enkurin"]
["ENSRNOG00000038132",15,1.26202903,5,0.321652191,3.92358288,1.972171675,0.004271359,2.930925E-3,"up","yes","Vsig4","protein_coding","chrX:61144928-61170212:-","gi|68163443|ref|NP_001020175.1|",1175,{"v":1E-156,"d":"1.00E-156"},"V-set and immunoglobulin domain-containing protein 4 precursor [Rattus norvegicus]","gi|68163442|ref|NM_001025004.1|",1404,0,"Rattus norvegicus V-set and immunoglobulin domain containing 4 (Vsig4), mRNA","Q9Y279",217,{"v":2e-63,"d":"2.00E-63"},"V-set and immunoglobulin domain-containing protein 4",".",".",".",".","pfam05476","PET122","PET122. The nuclear PET122 gene of S. cerevisiae encodes a mitochondrial-localized protein that activates initiation of translation of the mitochondrial mRNA from the COX3 gene, which encodes subunit III of cytochrome c oxidase.","GO:0032703|negative regulation of interleukin-2 production;GO:0042130|negative regulation of T cell proliferation;GO:0043031|negative regulation of macrophage activation;GO:0045957|negative regulation of complement activation, alternative pathway;","GO:0016021|integral component of membrane;GO:0032991|protein-containing complex;","GO:0001851|complement component C3b binding;","K19822","VSIG4, CRIg; V-set and immunoglobulin domain-containing protein 4"]
["ENSRNOG00000062810",15,1.26202903,5,0.321652191,3.92358288,1.972171675,0.004271359,2.930925E-3,"up","yes","ENSRNOG00000062810","protein_coding","chr12:18602770-18606953:-","gi|564323537|ref|XP_003754688.2|",1009,{"v":3e-130,"d":"3.00E-130"},"PREDICTED: LOW QUALITY PROTEIN: paired immunoglobulin-like type 2 receptor beta isoform X1 [Rattus norvegicus]","gi|672033532|ref|XM_003754640.3|",1482,0,"PREDICTED: Rattus norvegicus similar to paired immunoglobin-like type 2 receptor beta (LOC685181), transcript variant X1, mRNA","Q2YFS2",237,{"v":2e-72,"d":"2.00E-72"},"Paired immunoglobulin-like type 2 receptor beta",".",".",".",".","pfam03228","Adeno_VII","Adenoviral core protein VII. The function of this protein is unknown. It has a conserved amino terminus of 50 residues followed by a positively charged tail, suggesting it may interact with nucleic acid. The major core protein of the adenovirus, protein VII, was found to be associated with viral DNA throughout infection. The precursor to protein VII were shown to be in vivo and in vitro acceptors of ADP-ribose. The ADP-ribosylated core proteins were assembled into mature virus particles. ADP-ribosylation of adenovirus core proteins may have a role in virus decapsidation.",".",".",".",".","."]
["ENSRNOG00000063596",15,1.26202903,5,0.321652191,3.92358288,1.972171675,0.004271359,2.930925E-3,"up","yes","ENSRNOG00000063596","lncRNA","chr1:170790706-170795735:+","gi|149068172|gb|EDM17724.1|",176,{"v":3e-13,"d":"3.00E-13"},"rCG40283 [Rattus norvegicus]","gi|755479253|ref|XR_862865.1|",185,{"v":4E-90,"d":"4.00E-90"},"PREDICTED: Mus musculus uncharacterized LOC105243036 (LOC105243036), ncRNA",".",".",".",".",".",".",".",".","pfam14009","DUF4228","Domain of unknown function (DUF4228). This domain is found in plants. The function is not known.",".",".",".",".","."]
["ENSRNOG00000067729",15,1.26202903,5,0.321652191,3.92358288,1.972171675,0.004271359,2.930925E-3,"up","yes","ENSRNOG00000067729","lncRNA","chr7:67733989-67753442:-","gi|928078377|ref|XP_013889234.1|",345,{"v":8e-33,"d":"8.00E-33"},"PREDICTED: putative uncharacterized protein DDB_G0290521 [Austrofundulus limnaeus]","gi|672021791|ref|XR_601783.1|",4245,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103692886 (LOC103692886), ncRNA",".",".",".",".",".",".",".",".","pfam02093","Gag_p30","Gag P30 core shell protein. According to Swiss-Prot annotation this protein is the viral core shell protein. P30 is essential for viral assembly.",".",".",".",".","."]
["ENSRNOG00000070606",15,1.26202903,5,0.321652191,3.92358288,1.972171675,0.004271359,2.930925E-3,"up","yes","ENSRNOG00000070606","protein_coding","chr4:70001317-70014600:+","gi|228120|prf||1717324K",659,{"v":1e-75,"d":"1.00E-75"},"T cell receptor variable region:SUBUNIT=beta:ISOTYPE=8.1","gi|3192972|gb|AF044279.1|AF044279",824,0,"Rattus norvegicus strain Sprague-Dawley T cell receptor beta chain 5.2 (TCRBV5S2) gene, TCRBV5S2*1 allele, partial cds",".",".",".",".",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000011901",37,3.11300494,23,1.479600078,2.10395024,1.073100584,0.004323579,2.963023E-3,"up","yes","Rrad","protein_coding","chr19:354198-357417:+","gi|399498561|ref|NP_445790.2|",1313,{"v":1E-176,"d":"1.00E-176"},"GTP-binding protein RAD [Rattus norvegicus]","gi|672083957|ref|XM_006255055.2|",1531,0,"PREDICTED: Rattus norvegicus Ras-related associated with diabetes (Rrad), transcript variant X1, mRNA","O88667",503,{"v":2E-175,"d":"2.00E-175"},"GTP-binding protein RAD",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0030308|negative regulation of cell growth;GO:1901842|negative regulation of high voltage-gated calcium channel activity;","GO:0005575|cellular_component;GO:0005886|plasma membrane;","GO:0003674|molecular_function;GO:0003924|GTPase activity;GO:0005246|calcium channel regulator activity;GO:0005516|calmodulin binding;GO:0005525|GTP binding;","K07845","RRAD, RAD1; Ras-related associated with diabetes"]
["ENSRNOG00000066951",29,2.439922791,16,1.029287011,2.37049799,1.24519017,0.004437203,0.003030973,"up","yes","ENSRNOG00000066951","lncRNA","chr4:59661159-59662945:+",".",".",".",".","gi|66796238|gb|AC153820.4|",483,0,"Mus musculus 6 BAC RP23-459L15 (Roswell Park Cancer Institute (C57BL/6J Female) Mouse BAC Library) complete sequence",".",".",".",".",".",".",".",".","pfam15546","DUF4653","Domain of unknown function (DUF4653). This family of proteins is found in eukaryotes. Proteins in this family are typically between 93 and 229 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000013294",39,3.281275477,25,1.608260955,2.040263098,1.028755204,0.004651279,0.003166083,"up","yes","Sh2d2a","protein_coding","chr2:173312253-173318810:+","gi|57527970|ref|NP_997488.2|",1795,0,"SH2 domain-containing protein 2A [Rattus norvegicus]","gi|57527969|ref|NM_207605.3|",1562,0,"Rattus norvegicus SH2 domain containing 2A (Sh2d2a), mRNA","Q9QXK9",587,0,"SH2 domain-containing protein 2A",".",".",".",".","pfam00017","SH2","SH2 domain.","GO:0008283|cell proliferation;",".",".","K08273","SH2D2A, VRAP; SH2 domain-containing protein 2A"]
["ENSRNOG00000006730",7,0.588946881,0,0.032165219,18.31005344,4.194564097,0.004733313,0.003211084,"up","yes","Ccr1l1","protein_coding","chr8:123589621-123612687:-","gi|157822295|ref|NP_001100342.1|",1641,0,"C-C chemokine receptor 1-like protein 1 [Rattus norvegicus]","gi|157822294|ref|NM_001106872.1|",1071,0,"Rattus norvegicus chemokine (C-C motif) receptor 1-like 1 (Ccr1l1), mRNA","P51676",567,0,"C-C chemokine receptor 1-like protein 1",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0019722|calcium-mediated signaling;GO:0060326|cell chemotaxis;GO:0070098|chemokine-mediated signaling pathway;GO:0090026|positive regulation of monocyte chemotaxis;","GO:0005737|cytoplasm;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0016493|C-C chemokine receptor activity;GO:0019957|C-C chemokine binding;GO:0035717|chemokine (C-C motif) ligand 7 binding;GO:0071791|chemokine (C-C motif) ligand 5 binding;","K04176","CCR1, CD191; C-C chemokine receptor type 1"]
["ENSRNOG00000021345",7,0.588946881,0,0.032165219,18.31005344,4.194564097,0.004733313,0.003211084,"up","yes","Timd2","protein_coding","chr10:31060326-31094623:-","gi|672067246|ref|XP_008765889.1|",721,{"v":2E-87,"d":"2.00E-87"},"PREDICTED: T-cell immunoglobulin and mucin domain-containing protein 2 isoform X2 [Rattus norvegicus]","gi|62079096|ref|NM_001013855.1|",1334,0,"Rattus norvegicus T-cell immunoglobulin and mucin domain containing 2 (Timd2), mRNA","Q5FVR0",273,{"v":5e-86,"d":"5.00E-86"},"T-cell immunoglobulin and mucin domain-containing protein 2",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0006826|iron ion transport;GO:0006911|phagocytosis, engulfment;GO:0033005|positive regulation of mast cell activation;GO:0046718|viral entry into host cell;","GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0001618|virus receptor activity;GO:0001786|phosphatidylserine binding;GO:0070287|ferritin receptor activity;","K20413","HAVCR1, CD365; hepatitis A virus cellular receptor 1"]
["ENSRNOG00000026759",7,0.588946881,0,0.032165219,18.31005344,4.194564097,0.004733313,0.003211084,"up","yes","Ccr8","protein_coding","chr8:119826568-119827629:+","gi|672023455|ref|XP_008756107.1|",1718,0,"PREDICTED: C-C chemokine receptor type 8 [Rattus norvegicus]","gi|672023454|ref|XM_008757885.1|",1062,0,"PREDICTED: Rattus norvegicus chemokine (C-C motif) receptor 8 (Ccr8), mRNA","P56484",616,0,"C-C chemokine receptor type 8",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0006935|chemotaxis;GO:0006955|immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0019722|calcium-mediated signaling;GO:0060326|cell chemotaxis;GO:0070098|chemokine-mediated signaling pathway;","GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;","GO:0016493|C-C chemokine receptor activity;GO:0019957|C-C chemokine binding;","K04183","CCR8, CDw198; C-C chemokine receptor type 8"]
["ENSRNOG00000043215",7,0.588946881,0,0.032165219,18.31005344,4.194564097,0.004733313,0.003211084,"up","yes","Rtbdn","protein_coding","chr19:23197506-23204438:-","gi|157820793|ref|NP_001100635.1|",1194,{"v":8e-160,"d":"8.00E-160"},"retbindin precursor [Rattus norvegicus]","gi|157820792|ref|NM_001107165.1|",1513,0,"Rattus norvegicus retbindin (Rtbdn), mRNA","Q8QZY4",392,{"v":1e-132,"d":"1.00E-132"},"Retbindin",".",".",".",".","pfam03024","Folate_rec","Folate receptor family. This family includes the folate receptor which binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. These proteins are attached to the membrane by a GPI-anchor. The proteins contain 16 conserved cysteines that form eight disulphide bridges.","GO:0032218|riboflavin transport;","GO:0019897|extrinsic component of plasma membrane;GO:0031362|anchored component of external side of plasma membrane;GO:0033165|interphotoreceptor matrix;","GO:0032217|riboflavin transmembrane transporter activity;GO:0038023|signaling receptor activity;GO:1902444|riboflavin binding;",".","."]
["ENSRNOG00000048202",7,0.588946881,0,0.032165219,18.31005344,4.194564097,0.004733313,0.003211084,"up","yes","AABR07038553.1","protein_coding","chrX:50886684-50888014:-","gi|564399346|ref|XP_006257053.1|",1493,0,"PREDICTED: melanoma-associated antigen B2-like [Rattus norvegicus]","gi|672087738|ref|XM_006256991.2|",884,0,"PREDICTED: Rattus norvegicus melanoma antigen family B 1-like 1 (mageb1l1), transcript variant X2, mRNA","A2A9R3",328,{"v":2e-106,"d":"2.00E-106"},"Melanoma-associated antigen B4",".",".",".",".","pfam01454","MAGE","MAGE family. The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumors but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.",".",".",".",".","."]
["ENSRNOG00000052197",7,0.588946881,0,0.032165219,18.31005344,4.194564097,0.004733313,0.003211084,"up","yes","AABR07052859.1","snoRNA","chr3:76728823-76728928:+",".",".",".",".","gi|672060403|ref|XR_593658.1|",80,{"v":7e-33,"d":"7.00E-33"},"PREDICTED: Rattus norvegicus uncharacterized LOC102549144 (LOC102549144), transcript variant X4, ncRNA",".",".",".",".",".",".",".",".","pfam10123","Mu-like_Pro","Mu-like prophage I protein. Members of this family of proteins comprise various viral Mu-like prophage I proteins.",".",".",".",".","."]
["ENSRNOG00000056574",7,0.588946881,0,0.032165219,18.31005344,4.194564097,0.004733313,0.003211084,"up","yes","Tigit","protein_coding","chr11:57029118-57045994:+","gi|672026084|ref|XP_008774911.1|",1185,{"v":2e-162,"d":"2.00E-162"},"PREDICTED: T-cell immunoreceptor with Ig and ITIM domains isoform X1 [Rattus norvegicus]","gi|672071268|ref|XM_008768765.1|",764,0,"PREDICTED: Rattus norvegicus T cell immunoreceptor with Ig and ITIM domains (Tigit), transcript variant X1, mRNA","P86176",387,{"v":8e-135,"d":"8.00E-135"},"T-cell immunoreceptor with Ig and ITIM domains",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0032695|negative regulation of interleukin-12 production;GO:0032733|positive regulation of interleukin-10 production;GO:0050868|negative regulation of T cell activation;","GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0005102|signaling receptor binding;GO:0042802|identical protein binding;","K16350","TIGIT; T-cell immunoreceptor with Ig and ITIM domains"]
["ENSRNOG00000063907",7,0.588946881,0,0.032165219,18.31005344,4.194564097,0.004733313,0.003211084,"up","yes","U6","snRNA","chr15:18709102-18709208:+","gi|537152882|gb|ERE72362.1|",173,{"v":3e-14,"d":"3.00E-14"},"membralin-like protein [Cricetulus griseus]","gi|937346457|ref|NG_043110.1|",92,{"v":2e-39,"d":"2.00E-39"},"Homo sapiens RNA, U6 small nuclear 16, pseudogene (RNU6-16P) on chromosome 11",".",".",".",".",".",".",".",".","pfam04408","HA2","Helicase associated domain (HA2). This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.",".",".",".",".","."]
["ENSRNOG00000065326",7,0.588946881,0,0.032165219,18.31005344,4.194564097,0.004733313,0.003211084,"up","yes","ENSRNOG00000065326","pseudogene","chr6:120379316-120380148:+","gi|62024907|gb|AAH92041.1|",1108,{"v":1e-149,"d":"1.00E-149"},"Ribosomal protein SA [Mus musculus]","gi|298905765|emb|FQ212893.1|",444,0,"Rattus norvegicus TL0AAA50YM21 mRNA sequence","P14206",429,{"v":1E-150,"d":"1.00E-150"},"40S ribosomal protein SA","SPBC685.06",230,{"v":8E-73,"d":"8.00E-73"},"COG0052","pfam00318","Ribosomal_S2","Ribosomal protein S2.",".",".",".",".","."]
["ENSRNOG00000068051",7,0.588946881,0,0.032165219,18.31005344,4.194564097,0.004733313,0.003211084,"up","yes","ENSRNOG00000068051","lncRNA","chr1:206619457-206621850:+",".",".",".",".","gi|42517254|gb|AC134437.3|",586,0,"Mus musculus BAC clone RP24-450H12 from chromosome 19, complete sequence",".",".",".",".",".",".",".",".","pfam15483","DUF4641","Domain of unknown function (DUF4641). This family of proteins is found in eukaryotes. Proteins in this family are typically between 201 and 519 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000022838",30,2.524058059,17,1.093617449,2.30798993,1.206636929,0.00475587,0.003224848,"up","yes","Cnksr1","protein_coding","chr5:146447497-146458212:-","gi|149024214|gb|EDL80711.1|",3349,0,"rCG31469 [Rattus norvegicus]","gi|84781679|ref|NM_001039011.1|",2381,0,"Rattus norvegicus connector enhancer of kinase suppressor of Ras 1 (Cnksr1), mRNA","Q969H4",907,0,"Connector enhancer of kinase suppressor of ras 1",".",".",".",".","pfam10534","CRIC_ras_sig","Connector enhancer of kinase suppressor of ras. The CRIC - Connector enhancer of kinase suppressor of ras - domain functions as a scaffold in several signal cascades and acts on proliferation, differentiation and apoptosis.","GO:0007265|Ras protein signal transduction;GO:0007266|Rho protein signal transduction;GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005938|cell cortex;","GO:0003674|molecular_function;GO:0030674|protein binding, bridging;","K23783","CNKSR1, CNK1; connector enhancer of kinase suppressor of Ras 1"]
["ENSRNOG00000030431",30,2.524058059,17,1.093617449,2.30798993,1.206636929,0.00475587,0.003224848,"up","yes","RT1-Db2","protein_coding","chr20:4520713-4539705:-","gi|564396604|ref|XP_006255973.1|",1330,{"v":4e-173,"d":"4.00E-173"},"PREDICTED: RT1 class II, locus Db2 isoform X1 [Rattus norvegicus]","gi|46237557|emb|BX883043.1|",2051,0,"Rattus norvegicus chromosome 20, major histocompatibility complex, assembled from 40 BACs, strain Brown Norway (BN/ssNHsd), RT1n haplotype; segment 2/11","P29067",420,{"v":4E-136,"d":"4.00E-136"},"Beta-arrestin-2",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.","GO:0002250|adaptive immune response;GO:0002381|immunoglobulin production involved in immunoglobulin mediated immune response;GO:0002503|peptide antigen assembly with MHC class II protein complex;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0050870|positive regulation of T cell activation;","GO:0005765|lysosomal membrane;GO:0016021|integral component of membrane;GO:0031902|late endosome membrane;GO:0042613|MHC class II protein complex;","GO:0023026|MHC class II protein complex binding;","K06752","MHC2; MHC class II antigen"]
["ENSRNOG00000004575",10,0.841352686,2,0.128660876,6.5393048,2.70913727,0.004792717,3.246933E-3,"up","yes","Il1a","protein_coding","chr3:116526604-116536822:-","gi|8393593|ref|NP_058715.1|",1438,0,"interleukin-1 alpha precursor [Rattus norvegicus]","gi|8393592|ref|NM_017019.1|",1987,0,"Rattus norvegicus interleukin 1 alpha (Il1a), mRNA","P16598",558,0,"Interleukin-1 alpha",".",".",".",".","pfam02394","IL1_propep","Interleukin-1 propeptide. The Interleukin-1 cytokines are translated as precursor proteins. The N terminal approx. 115 amino acids form a propeptide that is cleaved off to release the active interleukin-1.","GO:0001660|fever generation;GO:0001666|response to hypoxia;GO:0001819|positive regulation of cytokine production;GO:0002248|connective tissue replacement involved in inflammatory response wound healing;GO:0002526|acute inflammatory response;GO:0006883|cellular sodium ion homeostasis;GO:0006954|inflammatory response;GO:0006955|immune response;GO:0007165|signal transduction;GO:0007283|spermatogenesis;GO:0007507|heart development;GO:0008285|negative regulation of cell proliferation;GO:0009408|response to heat;GO:0010033|response to organic substance;GO:0010193|response to ozone;GO:0010243|response to organonitrogen compound;GO:0010332|response to gamma radiation;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0010628|positive regulation of gene expression;GO:0010893|positive regulation of steroid biosynthetic process;GO:0014070|response to organic cyclic compound;GO:0019221|cytokine-mediated signaling pathway;GO:0031424|keratinization;GO:0032308|positive regulation of prostaglandin secretion;GO:0032496|response to lipopolysaccharide;GO:0032743|positive regulation of interleukin-2 production;GO:0032755|positive regulation of interleukin-6 production;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032874|positive regulation of stress-activated MAPK cascade;GO:0032956|regulation of actin cytoskeleton organization;GO:0033092|positive regulation of immature T cell proliferation in thymus;GO:0033591|response to L-ascorbic acid;GO:0034605|cellular response to heat;GO:0035234|ectopic germ cell programmed cell death;GO:0042060|wound healing;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045766|positive regulation of angiogenesis;GO:0045840|positive regulation of mitotic nuclear division;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046330|positive regulation of JNK cascade;GO:0046688|response to copper ion;GO:0050714|positive regulation of protein secretion;GO:0050999|regulation of nitric-oxide synthase activity;GO:0051781|positive regulation of cell division;GO:0051930|regulation of sensory perception of pain;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0070498|interleukin-1-mediated signaling pathway;GO:0071222|cellular response to lipopolysaccharide;GO:0071639|positive regulation of monocyte chemotactic protein-1 production;GO:0097192|extrinsic apoptotic signaling pathway in absence of ligand;GO:1902624|positive regulation of neutrophil migration;GO:1904445|negative regulation of establishment of Sertoli cell barrier;GO:2000391|positive regulation of neutrophil extravasation;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0009986|cell surface;","GO:0005125|cytokine activity;GO:0005149|interleukin-1 receptor binding;GO:0005507|copper ion binding;","K04383","IL1A; interleukin 1 alpha"]
["ENSRNOG00000019851",10,0.841352686,2,0.128660876,6.5393048,2.70913727,0.004792717,3.246933E-3,"up","yes","Cox6a2","protein_coding","chr1:182788528-182789274:-","gi|158517820|ref|NP_036944.2|",514,{"v":3e-64,"d":"3.00E-64"},"cytochrome c oxidase subunit 6A2, mitochondrial precursor [Rattus norvegicus]","gi|564330898|ref|XM_006230218.1|",475,0,"PREDICTED: Rattus norvegicus cytochrome c oxidase subunit VIa polypeptide 2 (Cox6a2), transcript variant X1, mRNA","P10817",196,{"v":2e-63,"d":"2.00E-63"},"Cytochrome c oxidase subunit 6A2, mitochondrial (Fragment)",".",".",".",".","pfam02046","COX6A","Cytochrome c oxidase subunit VIa.","GO:0006119|oxidative phosphorylation;GO:0006123|mitochondrial electron transport, cytochrome c to oxygen;GO:0022900|electron transport chain;GO:0050790|regulation of catalytic activity;GO:1902600|proton transmembrane transport;","GO:0005751|mitochondrial respiratory chain complex IV;GO:0016021|integral component of membrane;","GO:0004129|cytochrome-c oxidase activity;GO:0030234|enzyme regulator activity;","K02266","COX6A; cytochrome c oxidase subunit 6a"]
["ENSRNOG00000030093",10,0.841352686,2,0.128660876,6.5393048,2.70913727,0.004792717,3.246933E-3,"up","yes","Defa5","protein_coding","chr16:70342530-70344836:-","gi|564389781|ref|XP_006253429.1|",511,{"v":3e-63,"d":"3.00E-63"},"PREDICTED: alpha-defensin 5, Paneth cell-specific isoform X1 [Rattus norvegicus]","gi|564389780|ref|XM_006253367.1|",487,0,"PREDICTED: Rattus norvegicus defensin, alpha 5, Paneth cell-specific (Defa5), transcript variant X1, mRNA","Q62715",157,{"v":4e-48,"d":"4.00E-48"},"Neutrophil antibiotic peptide NP-2",".",".",".",".","pfam00879","Defensin_propep","Defensin propeptide.","GO:0002227|innate immune response in mucosa;GO:0019731|antibacterial humoral response;GO:0031640|killing of cells of other organism;GO:0042742|defense response to bacterium;GO:0045087|innate immune response;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:0050832|defense response to fungus;GO:0051673|membrane disruption in other organism;GO:0051873|killing by host of symbiont cells;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0071222|cellular response to lipopolysaccharide;GO:1905710|positive regulation of membrane permeability;","GO:0005615|extracellular space;GO:0030496|midbody;GO:0043231|intracellular membrane-bounded organelle;","GO:0042803|protein homodimerization activity;","K05230","DEFA; defensin, alpha"]
["ENSRNOG00000063191",10,0.841352686,2,0.128660876,6.5393048,2.70913727,0.004792717,3.246933E-3,"up","yes","ENSRNOG00000063191","protein_coding","chr3:90274659-90275975:-","gi|8393180|ref|NP_058898.1|",190,{"v":2E-16,"d":"2.00E-16"},"cytochrome c oxidase subunit 4 isoform 1, mitochondrial precursor [Rattus norvegicus]","gi|57032|emb|X54082.1|",119,{"v":4e-54,"d":"4.00E-54"},"Rat RCO4-2 DNA","P10888",77.8,{"v":6e-18,"d":"6.00E-18"},"Cytochrome c oxidase subunit 4 isoform 1, mitochondrial",".",".",".",".","pfam01275","Myelin_PLP","Myelin proteolipid protein (PLP or lipophilin).",".",".",".",".","."]
["ENSRNOG00000065100",10,0.841352686,2,0.128660876,6.5393048,2.70913727,0.004792717,3.246933E-3,"up","yes","ENSRNOG00000065100","protein_coding","chr15:33425586-33442327:-","gi|62079205|ref|NP_001014257.1|",1269,{"v":2E-171,"d":"2.00E-171"},"PHD finger protein 11-like [Rattus norvegicus]","gi|62079204|ref|NM_001014235.1|",1095,0,"Rattus norvegicus PHD finger protein 11B (Phf11b), mRNA","Q5I0J8",493,{"v":6e-173,"d":"6.00E-173"},"PHD finger protein 11-like",".",".",".",".","pfam13771","zf-HC5HC2H","PHD-like zinc-binding domain. The members of this family are annotated as containing PHD domain, but the zinc-binding region here is not typical of PHD domains. The conformation here is a well-conserved cysteine-histidine rich region spanning 90 residues, where the Cys and His are arranged as HxxC(31)CxxC(6)CxxCxxxxCxxxxHxxC (21)CxxH.",".",".",".",".","."]
["ENSRNOG00000005621",40,3.365410746,26,1.672591393,2.012093785,1.008697551,0.004799392,3.251051E-3,"up","yes","Gxylt2","protein_coding","chr4:133347499-133449454:+","gi|568941620|ref|XP_006506070.1|",1724,0,"PREDICTED: glucoside xylosyltransferase 2 isoform X1 [Mus musculus]","gi|672050601|ref|XM_001066466.4|",1385,0,"PREDICTED: Rattus norvegicus glucoside xylosyltransferase 2 (Gxylt2), mRNA","Q810K9",646,0,"Glucoside xylosyltransferase 2",".",".",".",".","pfam01501","Glyco_transf_8","Glycosyl transferase family 8. This family includes enzymes that transfer sugar residues to donor molecules. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. This family includes Lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, and glycogenin glucosyltransferase.","GO:0016266|O-glycan processing;",".","GO:0035252|UDP-xylosyltransferase activity;","K13676","GXYLT; UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase [EC:2.4.2.42]"]
["ENSRNOG00000031703",8,0.673082149,1,0.064330438,10.46288768,3.387209175,5.03755E-3,0.003399267,"up","yes","AABR07071294.1","protein_coding","chr8:100574894-100575268:-","gi|829902827|ref|XP_012591197.1|",376,{"v":1e-43,"d":"1.00E-43"},"PREDICTED: 40S ribosomal protein S25-like, partial [Microcebus murinus]","gi|298904423|emb|FQ221873.1|",335,{"v":6e-174,"d":"6.00E-174"},"Rattus norvegicus TL0ADA30YK23 mRNA sequence","Q6Q311",147,{"v":2e-44,"d":"2.00E-44"},"40S ribosomal protein S25","YGR027c",76.6,{"v":8e-18,"d":"8.00E-18"},"COG4901","pfam03297","Ribosomal_S25","S25 ribosomal protein.",".",".",".",".","."]
["ENSRNOG00000048468",8,0.673082149,1,0.064330438,10.46288768,3.387209175,5.03755E-3,0.003399267,"up","yes","Trbv1","protein_coding","chr4:69745507-69746444:+","gi|149065355|gb|EDM15431.1|",630,{"v":2e-80,"d":"2.00E-80"},"rCG28352, partial [Rattus norvegicus]","gi|60552823|gb|BC091428.1|",488,0,"Rattus norvegicus T-cell receptor beta chain, mRNA (cDNA clone MGC:109620 IMAGE:7367078), complete cds",".",".",".",".",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".",".",".",".","."]
["ENSRNOG00000050028",8,0.673082149,1,0.064330438,10.46288768,3.387209175,5.03755E-3,0.003399267,"up","yes","ENSRNOG00000050028","protein_coding","chr19:49605818-49618702:-","gi|564321602|ref|XP_006222840.1|",1225,{"v":4E-165,"d":"4.00E-165"},"PREDICTED: uncharacterized protein C16orf95 homolog isoform X1 [Rattus norvegicus]","gi|672031379|ref|XM_006222781.2|",1104,0,"PREDICTED: Rattus norvegicus hypothetical protein LOC687560 (LOC687560), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam15132","DUF4568","Domain of unknown function (DUF4568). This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes.",".",".",".",".","."]
["ENSRNOG00000063280",8,0.673082149,1,0.064330438,10.46288768,3.387209175,5.03755E-3,0.003399267,"up","yes","ENSRNOG00000063280","protein_coding","chr3:110790679-110790918:+","gi|724828529|ref|XP_010362681.1|",422,{"v":6E-51,"d":"6.00E-51"},"PREDICTED: 40S ribosomal protein S2-like [Rhinopithecus roxellana]","gi|2920832|gb|U92700.1|RNU92700",237,{"v":1E-119,"d":"1.00E-119"},"Rattus norvegicus ribosomal protein S2 mRNA, complete cds","P27952",169,{"v":7e-52,"d":"7.00E-52"},"40S ribosomal protein S2","SPCC576.08c",78.6,{"v":3e-18,"d":"3.00E-18"},"COG0098","pfam03719","Ribosomal_S5_C","Ribosomal protein S5, C-terminal domain.",".",".",".",".","."]
["ENSRNOG00000064350",8,0.673082149,1,0.064330438,10.46288768,3.387209175,5.03755E-3,0.003399267,"up","yes","ENSRNOG00000064350","lncRNA","chr10:44173921-44177651:-",".",".",".",".","gi|672024820|ref|XR_599418.1|",738,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103693339 (LOC103693339), ncRNA",".",".",".",".",".",".",".",".","pfam06728","PIG-U","GPI transamidase subunit PIG-U. Many eukaryotic proteins are anchored to the cell surface via glycosylphosphatidylinositol (GPI), which is posttranslationally attached to the carboxyl-terminus by GPI transamidase. The mammalian GPI transamidase is a complex of at least four subunits, GPI8, GAA1, PIG-S, and PIG-T. PIG-U is thought to represent a fifth subunit in this complex and may be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.",".",".",".",".","."]
["ENSRNOG00000066094",8,0.673082149,1,0.064330438,10.46288768,3.387209175,5.03755E-3,0.003399267,"up","yes","ENSRNOG00000066094","protein_coding","chr1:66638117-66656976:+","gi|672013049|ref|XP_008772623.1|",4883,0,"PREDICTED: zinc finger protein 271-like isoform X2 [Rattus norvegicus]","gi|672013048|ref|XM_008774401.1|",2942,0,"PREDICTED: Rattus norvegicus similar to zinc finger protein 418 (LOC691135), transcript variant X2, mRNA","A8MQ14",674,0,"Zinc finger protein 850",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.",".",".",".",".","."]
["ENSRNOG00000066219",8,0.673082149,1,0.064330438,10.46288768,3.387209175,5.03755E-3,0.003399267,"up","yes","ENSRNOG00000066219","lncRNA","chr10:33551706-33557237:-",".",".",".",".","gi|20068543|emb|AL606829.13|",532,0,"Mouse DNA sequence from clone RP23-10M12 on chromosome 11, complete sequence",".",".",".",".",".",".",".",".","pfam07262","DUF1436","Protein of unknown function (DUF1436). This family consists of several hypothetical bacterial proteins of around 160 residues in length. The function of this family is unknown.",".",".",".",".","."]
["ENSRNOG00000069754",8,0.673082149,1,0.064330438,10.46288768,3.387209175,5.03755E-3,0.003399267,"up","yes","ENSRNOG00000069754","protein_coding","chr1:47818557-47819763:+","gi|19424174|ref|NP_598209.1|",510,{"v":2e-62,"d":"2.00E-62"},"2'-deoxynucleoside 5'-phosphate N-hydrolase 1 [Rattus norvegicus]","gi|19424173|ref|NM_133525.1|",205,{"v":2e-101,"d":"2.00E-101"},"Rattus norvegicus 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 (Dnph1), mRNA","O35820",201,{"v":8e-64,"d":"8.00E-64"},"2'-deoxynucleoside 5'-phosphate N-hydrolase 1",".",".",".",".","pfam05014","Nuc_deoxyrib_tr","Nucleoside 2-deoxyribosyltransferase. Nucleoside 2-deoxyribosyltransferase EC:2.4.2.6 catalyses the cleavage of the glycosidic bonds of 2`-deoxyribonucleosides.",".",".",".",".","."]
["ENSRNOG00000068410",25,2.103381716,13,0.836295696,2.515117231,1.330625646,0.005409996,0.003628106,"up","yes","ENSRNOG00000068410","lncRNA","chr17:76128913-76136817:-","gi|965965757|ref|XP_014954934.1|",221,{"v":2E-19,"d":"2.00E-19"},"PREDICTED: LOW QUALITY PROTEIN: complement C1q-like protein 3 isoform X1 [Ovis aries]","gi|672082494|ref|XM_008771891.1|",806,0,"PREDICTED: Rattus norvegicus complement component 1, q subcomponent-like 3 (C1ql3), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam08886","GshA","Glutamate-cysteine ligase. This is a rare family of glutamate--cysteine ligases, EC:6.3.2.2, demonstrated first in Thiobacillus ferrooxidans and present in a few other Proteobacteria. It is the first of two enzymes for glutathione biosynthesis. It is also called gamma-glutamylcysteine synthetase. The structure of this family has been solved, and is similar to that of human glutathione synthetase and very different to gamma-glutamylcysteine synthetase from Escherichia coli.",".",".",".",".","."]
["ENSRNOG00000027468",16,1.346164298,6,0.385982629,3.487629227,1.802246674,0.005479175,0.003672239,"up","yes","Slc6a15","protein_coding","chr7:38553196-38607239:+","gi|27229292|ref|NP_758824.1|",3555,0,"sodium-dependent neutral amino acid transporter B(0)AT2 [Rattus norvegicus]","gi|27229291|ref|NM_172321.1|",3468,0,"Rattus norvegicus solute carrier family 6 member 15 (Slc6a15), mRNA","Q08469",1373,0,"Sodium-dependent neutral amino acid transporter B(0)AT2","VC2012",117,{"v":2e-26,"d":"2.00E-26"},"COG0733","pfam00209","SNF","Sodium:neurotransmitter symporter family.","GO:0003333|amino acid transmembrane transport;GO:0006836|neurotransmitter transport;GO:0015804|neutral amino acid transport;GO:0015820|leucine transport;GO:0015824|proline transport;GO:0035725|sodium ion transmembrane transport;","GO:0005887|integral component of plasma membrane;","GO:0005298|proline:sodium symporter activity;","K05048","SLC6A15S; solute carrier family 6 (neurotransmitter transporter, amino acid/orphan) member 15/16/17/18/20"]
["ENSRNOG00000045677",16,1.346164298,6,0.385982629,3.487629227,1.802246674,0.005479175,0.003672239,"up","yes","Nlrp6","protein_coding","chr1:196004953-196011113:+","gi|672039000|ref|XP_006230569.2|",4289,0,"PREDICTED: LOW QUALITY PROTEIN: NACHT, LRR and PYD domains-containing protein 6-like [Rattus norvegicus]","gi|672038999|ref|XM_006230507.2|",2955,0,"PREDICTED: Rattus norvegicus NACHT, LRR and PYD domains-containing protein 6-like (LOC103690037), mRNA","Q63035",1622,0,"NACHT, LRR and PYD domains-containing protein 6",".",".",".",".","pfam05729","NACHT","NACHT domain. This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.","GO:0002438|acute inflammatory response to antigenic stimulus;GO:0002526|acute inflammatory response;GO:0002862|negative regulation of inflammatory response to antigenic stimulus;GO:0007186|G protein-coupled receptor signaling pathway;GO:0009617|response to bacterium;GO:0010506|regulation of autophagy;GO:0032689|negative regulation of interferon-gamma production;GO:0034122|negative regulation of toll-like receptor signaling pathway;GO:0042060|wound healing;GO:0043124|negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043409|negative regulation of MAPK cascade;GO:0045087|innate immune response;GO:0050727|regulation of inflammatory response;GO:0050777|negative regulation of immune response;GO:0070255|regulation of mucus secretion;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0070946|neutrophil mediated killing of gram-positive bacterium;GO:0097202|activation of cysteine-type endopeptidase activity;","GO:0005886|plasma membrane;GO:0031965|nuclear membrane;GO:0061702|inflammasome complex;","GO:0005000|vasopressin receptor activity;GO:0005524|ATP binding;GO:0042277|peptide binding;","K20863","NLRP6, NALP6; NACHT, LRR and PYD domains-containing protein 6"]
["ENSRNOG00000069349",16,1.346164298,6,0.385982629,3.487629227,1.802246674,0.005479175,0.003672239,"up","yes","ENSRNOG00000069349","lncRNA","chr3:157193604-157198233:+",".",".",".",".","gi|672017758|ref|XR_600482.1|",495,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102554533 (LOC102554533), ncRNA",".",".",".",".",".",".",".",".","pfam04148","Erv26","Transmembrane adaptor Erv26. Erv26 is an integral membrane protein that is packed into COPII vesicles and cycles between the ER and Golgi compartments. It directs pro-alkaline phosphatase into endoplasmic reticulum-derived COPII transport vesicles.",".",".",".",".","."]
["ENSRNOG00000012307",33,2.776463865,20,1.286608764,2.157970584,1.109675199,0.00562075,0.003758335,"up","yes","Mybpc3","protein_coding","chr3:77095252-77113405:+","gi|564341755|ref|XP_006234565.1|",6507,0,"PREDICTED: myosin-binding protein C, cardiac-type isoform X1 [Rattus norvegicus]","gi|564341756|ref|XM_006234504.1|",4165,0,"PREDICTED: Rattus norvegicus myosin binding protein C, cardiac (Mybpc3), transcript variant X1, mRNA","P56741",2498,0,"Myosin-binding protein C, cardiac-type",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0002027|regulation of heart rate;GO:0003007|heart morphogenesis;GO:0006936|muscle contraction;GO:0006942|regulation of striated muscle contraction;GO:0007155|cell adhesion;GO:0008016|regulation of heart contraction;GO:0031034|myosin filament assembly;GO:0045214|sarcomere organization;GO:0055010|ventricular cardiac muscle tissue morphogenesis;GO:0060048|cardiac muscle contraction;","GO:0005863|striated muscle myosin thick filament;GO:0030016|myofibril;GO:0030017|sarcomere;GO:0031672|A band;GO:0097512|cardiac myofibril;","GO:0003674|molecular_function;GO:0003779|actin binding;GO:0008307|structural constituent of muscle;GO:0017022|myosin binding;GO:0032036|myosin heavy chain binding;GO:0042802|identical protein binding;GO:0046872|metal ion binding;","K12568","MYBPC3; myosin-binding protein C, cardiac-type"]
["ENSRNOG00000015024",33,2.776463865,20,1.286608764,2.157970584,1.109675199,0.00562075,0.003758335,"up","yes","Mcoln3","protein_coding","chr2:234966010-235043047:+","gi|58865684|ref|NP_001012059.1|",2921,0,"mucolipin-3 [Rattus norvegicus]","gi|58865683|ref|NM_001012059.1|",1831,0,"Rattus norvegicus mucolipin 3 (Mcoln3), mRNA","Q8R4F0",1096,0,"Mucolipin-3",".",".",".",".","pfam08016","PKD_channel","Polycystin cation channel. This family contains the cation channel region of PKD1 and PKD2 proteins.","GO:0007605|sensory perception of sound;GO:0007626|locomotory behavior;GO:0042491|inner ear auditory receptor cell differentiation;GO:0051209|release of sequestered calcium ion into cytosol;","GO:0005737|cytoplasm;GO:0005765|lysosomal membrane;GO:0005886|plasma membrane;GO:0010008|endosome membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0072345|NAADP-sensitive calcium-release channel activity;","K04994","MCOLN3, TRPML3; mucolipin 3"]
["ENSRNOG00000066929",33,2.776463865,20,1.286608764,2.157970584,1.109675199,0.00562075,0.003758335,"up","yes","ENSRNOG00000066929","lncRNA","chr4:5888039-5889614:-","gi|149060708|gb|EDM11422.1|",132,{"v":1e-06,"d":"1.00E-06"},"rCG52991, isoform CRA_d [Rattus norvegicus]","gi|76362972|gb|AC164700.3|",365,0,"Mus musculus BAC clone RP24-548M16 from chromosome 5, complete sequence",".",".",".",".",".",".",".",".","pfam06500","DUF1100","Alpha/beta hydrolase of unknown function (DUF1100). This family consists of several hypothetical bacterial proteins of unknown function. Members of this family have an alpha/beta hydrolase fold.",".",".",".",".","."]
["ENSRNOG00000026764",13,1.093758492,4,0.257321753,4.25054812,2.087648893,0.005779099,0.003854748,"up","yes","Pla2g4c","protein_coding","chr1:74236211-74274656:+","gi|564326380|ref|XP_006228397.1|",3259,0,"PREDICTED: cytosolic phospholipase A2 gamma-like isoform X3 [Rattus norvegicus]","gi|672035342|ref|XM_008759024.1|",2408,0,"PREDICTED: Rattus norvegicus similar to phospholipase A2, group IVC (cytosolic, calcium-independent) (LOC691813), transcript variant X5, mRNA","Q64GA5",917,0,"Cytosolic phospholipase A2 gamma",".",".",".",".","pfam01735","PLA2_B","Lysophospholipase catalytic domain. This family consists of Lysophospholipase / phospholipase B EC:3.1.1.5 and cytosolic phospholipase A2 EC:3.1.4 which also has a C2 domain pfam00168. Phospholipase B enzymes catalyse the release of fatty acids from lysophsopholipids and are capable in vitro of hydrolysing all phospholipids extractable form yeast cells. Cytosolic phospholipase A2 associates with natural membranes in response to physiological increases in Ca2+ and selectively hydrolyses arachidonyl phospholipids, the aligned region corresponds the the carboxy-terminal Ca2+-independent catalytic domain of the protein as discussed in.","GO:0006663|platelet activating factor biosynthetic process;GO:0036151|phosphatidylcholine acyl-chain remodeling;GO:0036152|phosphatidylethanolamine acyl-chain remodeling;GO:0046475|glycerophospholipid catabolic process;GO:0140042|lipid droplet formation;","GO:0005635|nuclear envelope;GO:0005654|nucleoplasm;GO:0005789|endoplasmic reticulum membrane;GO:0005811|lipid droplet;GO:0005829|cytosol;GO:0005938|cell cortex;GO:0031966|mitochondrial membrane;","GO:0004622|lysophospholipase activity;GO:0004623|phospholipase A2 activity;GO:0005509|calcium ion binding;GO:0005544|calcium-dependent phospholipid binding;GO:0008374|O-acyltransferase activity;GO:0047498|calcium-dependent phospholipase A2 activity;GO:0047499|calcium-independent phospholipase A2 activity;","K16342","PLA2G4, CPLA2; cytosolic phospholipase A2 [EC:3.1.1.4]"]
["ENSRNOG00000027873",13,1.093758492,4,0.257321753,4.25054812,2.087648893,0.005779099,0.003854748,"up","yes","RT1-M1-4","protein_coding","chr20:1889164-1893815:-","gi|149029336|gb|EDL84596.1|",1574,0,"rCG64183, partial [Rattus norvegicus]","gi|46237681|emb|BX883051.1|",1444,0,"Rattus norvegicus chromosome 20, major histocompatibility complex, assembled from 40 BACs, strain Brown Norway (BN/ssNHsd), RT1n haplotype; segment 10/11","P30515",300,{"v":3e-91,"d":"3.00E-91"},"Saoe class I histocompatibility antigen, A alpha chain",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.",".",".",".",".","."]
["ENSRNOG00000035633",13,1.093758492,4,0.257321753,4.25054812,2.087648893,0.005779099,0.003854748,"up","yes","Mir142","miRNA","chr10:72557857-72557967:+",".",".",".",".","gi|982305356|ref|XM_015438367.1|",111,{"v":5e-50,"d":"5.00E-50"},"PREDICTED: Macaca fascicularis benzodiazepine receptor (peripheral) associated protein 1 (BZRAP1), transcript variant X21, mRNA",".",".",".",".",".",".",".",".","pfam02277","DBI_PRT","Phosphoribosyltransferase. This family of proteins represent the nicotinate-nucleotide- dimethylbenzimidazole phosphoribosyltransferase (NN:DBI PRT) enzymes involved in dimethylbenzimidazole synthesis. This function is essential to de novo cobalamin (vitamin B12) production in bacteria. Nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazole (DMB) phosphoribosyltransferase (CobT) from Salmonella enterica plays a central role in the synthesis of alpha-ribazole-5'-phosphate, an intermediate for the lower ligand of cobalamin.","GO:0036294|cellular response to decreased oxygen levels;GO:0071222|cellular response to lipopolysaccharide;GO:0071391|cellular response to estrogen stimulus;GO:1990830|cellular response to leukemia inhibitory factor;",".",".","K17022","MIR142; microRNA 142"]
["ENSRNOG00000037217",13,1.093758492,4,0.257321753,4.25054812,2.087648893,0.005779099,0.003854748,"up","yes","Nudt17","protein_coding","chr2:184241468-184243960:-","gi|157819083|ref|NP_001102810.1|",1455,0,"nucleoside diphosphate-linked moiety X motif 17 [Rattus norvegicus]","gi|157819082|ref|NM_001109340.1|",1118,0,"Rattus norvegicus nudix hydrolase 17 (Nudt17), mRNA","Q9CWD3",505,{"v":2e-178,"d":"2.00E-178"},"Nucleoside diphosphate-linked moiety X motif 17",".",".",".",".","pfam00293","NUDIX","NUDIX domain.","GO:0006734|NADH metabolic process;GO:0006742|NADP catabolic process;GO:0019677|NAD catabolic process;","GO:0005777|peroxisome;GO:0005829|cytosol;","GO:0035529|NADH pyrophosphatase activity;",".","."]
["ENSRNOG00000065204",13,1.093758492,4,0.257321753,4.25054812,2.087648893,0.005779099,0.003854748,"up","yes","Fam166b","protein_coding","chr5:57675462-57678611:-","gi|532038518|ref|XP_005362126.1|",1161,{"v":9E-157,"d":"9.00E-157"},"PREDICTED: protein FAM166B isoform X1 [Microtus ochrogaster]","gi|755506548|ref|XM_006538012.2|",747,0,"PREDICTED: Mus musculus family with sequence similarity 166, member B (Fam166b), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam10629","DUF2475","Protein of unknown function (DUF2475). This family of proteins has no known function.",".",".",".",".","."]
["ENSRNOG00000067991",13,1.093758492,4,0.257321753,4.25054812,2.087648893,0.005779099,0.003854748,"up","yes","ENSRNOG00000067991","lncRNA","chr14:66856155-66873358:-","gi|74226034|dbj|BAE28765.1|",236,{"v":3e-21,"d":"3.00E-21"},"unnamed protein product [Mus musculus]","gi|672028002|ref|XR_593873.1|",668,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102552900 (LOC102552900), transcript variant X1, ncRNA",".",".",".",".",".",".",".",".","pfam03157","Glutenin_hmw","High molecular weight glutenin subunit. Members of this family include high molecular weight subunits of glutenin. This group of gluten proteins is thought to be largely responsible for the elastic properties of gluten, and hence, doughs. Indeed, glutenin high molecular weight subunits are classified as elastomeric proteins, because the glutenin network can withstand significant deformations without breaking, and return to the original conformation when the stress is removed. Elastomeric proteins differ considerably in amino acid sequence, but they are all polymers whose subunits consist of elastomeric domains, composed of repeated motifs, and non-elastic domains that mediate cross-linking between the subunits. The elastomeric domain motifs are all rich in glycine residues in addition to other hydrophobic residues. High molecular weight glutenin subunits have an extensive central elastomeric domain, flanked by two terminal non-elastic domains that form disulphide cross-links. The central elastomeric domain is characterized by the following three repeated motifs: PGQGQQ, GYYPTS[P/L]QQ, GQQ. It possesses overlapping beta-turns within and between the repeated motifs, and assumes a regular helical secondary structure with a diameter of approx. 1.9 nm and a pitch of approx. 1.5 nm.",".",".",".",".","."]
["ENSRNOG00000027228",26,2.187516985,14,0.900626135,2.42888464,1.280293971,5.900728E-3,0.003924817,"up","yes","Mogat2","protein_coding","chr1:153521815-153545756:-","gi|210031518|ref|NP_001102906.2|",1770,0,"2-acylglycerol O-acyltransferase 2 [Rattus norvegicus]","gi|210031517|ref|NM_001109436.2|",1746,0,"Rattus norvegicus monoacylglycerol O-acyltransferase 2 (Mogat2), mRNA","Q80W94",660,0,"2-acylglycerol O-acyltransferase 2",".",".",".",".","pfam03982","DAGAT","Diacylglycerol acyltransferase. The terminal step of triacylglycerol (TAG) formation is catalysed by the enzyme diacylglycerol acyltransferase (DAGAT).","GO:0006629|lipid metabolic process;GO:0006640|monoacylglycerol biosynthetic process;GO:0006651|diacylglycerol biosynthetic process;GO:0019432|triglyceride biosynthetic process;GO:0050892|intestinal absorption;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:1990578|perinuclear endoplasmic reticulum membrane;","GO:0003846|2-acylglycerol O-acyltransferase activity;GO:0008374|O-acyltransferase activity;GO:0016407|acetyltransferase activity;","K14457","MOGAT2, MGAT2; 2-acylglycerol O-acyltransferase 2 [EC:2.3.1.22]"]
["ENSRNOG00000050767",21,1.766840642,10,0.643304382,2.746508016,1.457598503,0.00629846,0.004164438,"up","yes","Nrn1","protein_coding","chr17:28129977-28138896:+","gi|556752844|ref|XP_005971807.1|",567,{"v":1e-65,"d":"1.00E-65"},"PREDICTED: neuritin [Pantholops hodgsonii]","gi|16758969|ref|NM_053346.1|",1571,0,"Rattus norvegicus neuritin 1 (Nrn1), mRNA","O08957",218,{"v":9e-67,"d":"9.00E-67"},"Neuritin",".",".",".",".","pfam15056","NRN1","Neuritin protein family. The domain family Neuritin1 (NRN1) is a GPI-anchored protein expressed in post-mitotic-differentiating neurons in the developing nervous system. NRN1 is a glutamate and neurotrophin receptor target encoding a neuronal protein that functions extracellularly to modulate neurite outgrowth (OMIM:607409).   This family of proteins is found in eukaryotes. Proteins in this family are typically between and 158 amino acids in length.","GO:0007399|nervous system development;GO:1990138|neuron projection extension;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0005615|extracellular space;GO:0016020|membrane;GO:0032281|AMPA glutamate receptor complex;GO:0046658|anchored component of plasma membrane;GO:0098978|glutamatergic synapse;","GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000053631",27,2.271652253,15,0.964956573,2.354149728,1.235206081,0.006369653,0.004207422,"up","yes","Tdrd9","protein_coding","chr6:131029652-131144651:+","gi|293348275|ref|XP_001072421.2|",7050,0,"PREDICTED: putative ATP-dependent RNA helicase TDRD9 isoform X4 [Rattus norvegicus]","gi|672021189|ref|XM_001072421.4|",4373,0,"PREDICTED: Rattus norvegicus tudor domain containing 9 (Tdrd9), transcript variant X4, mRNA","Q3MHU3",2696,0,"ATP-dependent RNA helicase TDRD9","HI1070",261,{"v":3e-70,"d":"3.00E-70"},"COG1643","pfam04408","HA2","Helicase associated domain (HA2). This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.","GO:0007140|male meiotic nuclear division;GO:0007141|male meiosis I;GO:0007283|spermatogenesis;GO:0009566|fertilization;GO:0010529|negative regulation of transposition;GO:0030154|cell differentiation;GO:0031047|gene silencing by RNA;GO:0034587|piRNA metabolic process;GO:0043046|DNA methylation involved in gamete generation;","GO:0005622|intracellular;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0071547|piP-body;","GO:0003723|RNA binding;GO:0003724|RNA helicase activity;GO:0005524|ATP binding;","K18408","TDRD9; ATP-dependent RNA helicase TDRD9 [EC:3.6.4.13]"]
["ENSRNOG00000016311",17,1.430299567,7,0.450313067,3.17623376,1.667317094,0.006703582,0.004406612,"up","yes","Slc6a2","protein_coding","chr19:14010386-14050357:-","gi|13786180|ref|NP_112633.1|",2957,0,"sodium-dependent noradrenaline transporter [Rattus norvegicus]","gi|13786179|ref|NM_031343.1|",2172,0,"Rattus norvegicus solute carrier family 6 (neurotransmitter transporter), member 2 (Slc6a2), mRNA","O55192",1031,0,"Sodium-dependent noradrenaline transporter","VC2012",212,{"v":5e-59,"d":"5.00E-59"},"COG0733","pfam00209","SNF","Sodium:neurotransmitter symporter family.","GO:0006836|neurotransmitter transport;GO:0009410|response to xenobiotic stimulus;GO:0015844|monoamine transport;GO:0015874|norepinephrine transport;GO:0035725|sodium ion transmembrane transport;GO:0048265|response to pain;GO:0051583|dopamine uptake involved in synaptic transmission;GO:0051620|norepinephrine uptake;GO:0098810|neurotransmitter reuptake;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0032809|neuronal cell body membrane;GO:0042734|presynaptic membrane;GO:0043005|neuron projection;GO:0045121|membrane raft;","GO:0003779|actin binding;GO:0005326|neurotransmitter transporter activity;GO:0005328|neurotransmitter:sodium symporter activity;GO:0005330|dopamine:sodium symporter activity;GO:0005334|norepinephrine:sodium symporter activity;GO:0005515|protein binding;GO:0008504|monoamine transmembrane transporter activity;GO:0043014|alpha-tubulin binding;GO:0048487|beta-tubulin binding;","K05035","SLC6A2, NET; solute carrier family 6 (neurotransmitter transporter, noradrenalin) member 2"]
["ENSRNOG00000018366",17,1.430299567,7,0.450313067,3.17623376,1.667317094,0.006703582,0.004406612,"up","yes","Cracdl","protein_coding","chr9:39834833-39951086:-","gi|564311478|ref|XP_006226868.1|",5362,0,"PREDICTED: uncharacterized protein KIAA1211-like homolog isoform X3 [Rattus norvegicus]","gi|672023934|ref|XM_006226804.2|",3511,0,"PREDICTED: Rattus norvegicus similar to putative protein (5S487) (RGD1310819), transcript variant X7, mRNA",".",".",".",".",".",".",".",".","pfam15262","DUF4592","Domain of unknown function (DUF4592). This protein family is a domain of unknown function, which lies to the N-terminus of the protein. This domain family is found in eukaryotes, and is typically between 114 and 130 amino acids in length. There are two completely conserved residues (L and A) that may be functionally important. In humans, the gene that encodes this protein lies in the position, chromosome 2 open reading frame 55.",".",".",".",".","."]
["ENSRNOG00000026787",17,1.430299567,7,0.450313067,3.17623376,1.667317094,0.006703582,0.004406612,"up","yes","Disp2","protein_coding","chr3:105762305-105777800:+","gi|149022987|gb|EDL79881.1|",6099,0,"dispatched homolog 2 (Drosophila) (predicted), isoform CRA_f [Rattus norvegicus]","gi|672046546|ref|XM_006234756.2|",5952,0,"PREDICTED: Rattus norvegicus dispatched homolog 2 (Drosophila) (Disp2), transcript variant X1, mRNA","Q8CIP5",2201,0,"Protein dispatched homolog 2",".",".",".",".","pfam03176","MMPL","MMPL family. Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.",".","GO:0016021|integral component of membrane;",".","K24681","DISP2; protein dispatched 2"]
["ENSRNOG00000058372",17,1.430299567,7,0.450313067,3.17623376,1.667317094,0.006703582,0.004406612,"up","yes","Ac1576","protein_coding","chr10:68914830-68930985:-","gi|567316103|ref|NP_001274553.1|",1970,0,"uncharacterized protein LOC102552783 [Rattus norvegicus]","gi|567316102|ref|NM_001287624.1|",1143,0,"Rattus norvegicus uncharacterized LOC102552783 (Ac1576), mRNA","P12894",145,{"v":3e-36,"d":"3.00E-36"},"Intracisternal A-particle Pol-related polyprotein (Fragment)",".",".",".",".","pfam00552","IN_DBD_C","Integrase DNA binding domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain. The central domain is the catalytic domain pfam00665. This domain is the carboxyl terminal domain that is a non-specific DNA binding domain.",".",".",".",".","."]
["ENSRNOG00000063658",17,1.430299567,7,0.450313067,3.17623376,1.667317094,0.006703582,0.004406612,"up","yes","ENSRNOG00000063658","lncRNA","chr3:116404250-116413702:-","gi|149036607|gb|EDL91225.1|",228,{"v":3e-19,"d":"3.00E-19"},"rCG56442 [Rattus norvegicus]","gi|256985244|gb|AC121664.5|",1387,0,"Rattus norvegicus CH230-383I17 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam10192","GpcrRhopsn4","Rhodopsin-like GPCR transmembrane domain. This region of 270 amino acids is the seven transmembrane alpha-helical domains included within five GPCRRHODOPSN4 motifs of a G-protein-coupled-receptor (GPCR) protein, conserved from nematodes to humans. GPCRs are integral membrane receptors whose intracellular actions are mediated by signalling pathways involving G proteins and downstream secondary messengers.",".",".",".",".","."]
["ENSRNOG00000011016",29,2.439922791,17,1.093617449,2.231056932,1.157727329,0.007235024,0.004718925,"up","yes","Slc7a2","protein_coding","chr16:51417493-51470784:-","gi|672080252|ref|XP_008769503.1|",3258,0,"PREDICTED: low affinity cationic amino acid transporter 2 isoform X1 [Rattus norvegicus]","gi|402746476|ref|NM_001134686.2|",2482,0,"Rattus norvegicus solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 (Slc7a2), transcript variant 2, mRNA","B5D5N9",1212,0,"Cationic amino acid transporter 2","XF2207",238,{"v":6E-68,"d":"6.00E-68"},"COG0531","pfam13520","AA_permease_2","Amino acid permease.","GO:0002537|nitric oxide production involved in inflammatory response;GO:0006809|nitric oxide biosynthetic process;GO:0006865|amino acid transport;GO:0015807|L-amino acid transport;GO:0015809|arginine transport;GO:0042116|macrophage activation;GO:0043030|regulation of macrophage activation;GO:0050727|regulation of inflammatory response;GO:0089718|amino acid import across plasma membrane;GO:0097638|L-arginine import across plasma membrane;GO:0097639|L-lysine import across plasma membrane;GO:0097640|L-ornithine import across plasma membrane;GO:1902023|L-arginine transport;GO:1902475|L-alpha-amino acid transmembrane transport;GO:1903352|L-ornithine transmembrane transport;GO:1903401|L-lysine transmembrane transport;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030054|cell junction;","GO:0000064|L-ornithine transmembrane transporter activity;GO:0005289|high-affinity arginine transmembrane transporter activity;GO:0005292|high-affinity lysine transmembrane transporter activity;GO:0015171|amino acid transmembrane transporter activity;GO:0015179|L-amino acid transmembrane transporter activity;GO:0015181|arginine transmembrane transporter activity;GO:0015189|L-lysine transmembrane transporter activity;GO:0061459|L-arginine transmembrane transporter activity;GO:0097626|low-affinity L-arginine transmembrane transporter activity;GO:0097627|high-affinity L-ornithine transmembrane transporter activity;","K13864","SLC7A2, ATRC2; solute carrier family 7 (cationic amino acid transporter), member 2"]
["ENSRNOG00000021149",29,2.439922791,17,1.093617449,2.231056932,1.157727329,0.007235024,0.004718925,"up","yes","Ush1c","protein_coding","chr1:96695307-96743671:-","gi|564328433|ref|XP_006229284.1|",3920,0,"PREDICTED: harmonin isoform X2 [Rattus norvegicus]","gi|672036495|ref|XM_006229222.2|",2851,0,"PREDICTED: Rattus norvegicus Usher syndrome 1C (Ush1c), transcript variant X2, mRNA","Q9ES64",1473,0,"Harmonin",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.","GO:0000086|G2/M transition of mitotic cell cycle;GO:0007605|sensory perception of sound;GO:0030046|parallel actin filament bundle assembly;GO:0032532|regulation of microvillus length;GO:0034622|cellular protein-containing complex assembly;GO:0042472|inner ear morphogenesis;GO:0042491|inner ear auditory receptor cell differentiation;GO:0045494|photoreceptor cell maintenance;GO:0046549|retinal cone cell development;GO:0050885|neuromuscular process controlling balance;GO:0050953|sensory perception of light stimulus;GO:0050957|equilibrioception;GO:0051017|actin filament bundle assembly;GO:0060122|inner ear receptor cell stereocilium organization;GO:1904106|protein localization to microvillus;GO:1904970|brush border assembly;","GO:0001750|photoreceptor outer segment;GO:0001917|photoreceptor inner segment;GO:0002142|stereocilia ankle link complex;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0005902|microvillus;GO:0005903|brush border;GO:0032391|photoreceptor connecting cilium;GO:0032420|stereocilium;GO:0032426|stereocilium tip;GO:0045177|apical part of cell;GO:0045202|synapse;GO:1990435|upper tip-link density;","GO:0030507|spectrin binding;GO:0032029|myosin tail binding;GO:0051015|actin filament binding;","K21877","USH1C; harmonin"]
["ENSRNOG00000005929",11,0.925487955,3,0.192991315,4.795490187,2.261678293,0.007611821,0.004945727,"up","yes","Them6","protein_coding","chr7:106606570-106609746:+","gi|56090359|ref|NP_001007659.1|",980,{"v":9e-128,"d":"9.00E-128"},"protein THEM6 precursor [Rattus norvegicus]","gi|56090358|ref|NM_001007658.1|",1541,0,"Rattus norvegicus thioesterase superfamily member 6 (Them6), mRNA","Q5XIE1",382,{"v":3e-129,"d":"3.00E-129"},"Protein THEM6",".",".",".",".","pfam13279","4HBT_2","Thioesterase-like superfamily. This family contains a wide variety of enzymes, principally thioesterases. These enzymes are part of the Hotdog fold superfamily.","GO:0008150|biological_process;","GO:0005575|cellular_component;GO:0005576|extracellular region;","GO:0003674|molecular_function;",".","."]
["ENSRNOG00000010345",11,0.925487955,3,0.192991315,4.795490187,2.261678293,0.007611821,0.004945727,"up","yes","Ssmem1","protein_coding","chr4:59128730-59145007:+","gi|157823083|ref|NP_001102698.1|",960,{"v":3e-125,"d":"3.00E-125"},"serine-rich single-pass membrane protein 1 [Rattus norvegicus]","gi|157823082|ref|NM_001109228.1|",1484,0,"Rattus norvegicus serine-rich single-pass membrane protein 1 (Ssmem1), mRNA","Q4R309",201,{"v":5e-59,"d":"5.00E-59"},"Serine-rich single-pass membrane protein 1",".",".",".",".","pfam15468","DUF4636","Domain of unknown function (DUF4636). This family of proteins is found in eukaryotes. Proteins in this family are typically between 196 and 244 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000024712",11,0.925487955,3,0.192991315,4.795490187,2.261678293,0.007611821,0.004945727,"up","yes","Insc","protein_coding","chr1:168993032-169100433:+","gi|157820611|ref|NP_001099755.1|",2631,0,"protein inscuteable homolog [Rattus norvegicus]","gi|157820610|ref|NM_001106285.1|",1774,0,"Rattus norvegicus inscuteable homolog (Drosophila) (Insc), mRNA","Q3HNM7",994,0,"Protein inscuteable homolog",".",".",".",".","pfam09511","RNA_lig_T4_1","RNA ligase. Members of this family include T4 phage proteins with ATP-dependent RNA ligase activity. Host defence to phage may include cleavage and inactivation of specific tRNA molecules; members of this family act to reverse this RNA damage. The enzyme is adenylated, transiently, on a Lys residue in a motif KXDGSL. This family also includes fungal tRNA ligases that have adenylyltransferase activity. tRNA ligases are enzymes required for the splicing of precursor tRNA molecules containing introns.","GO:0000132|establishment of mitotic spindle orientation;GO:0008356|asymmetric cell division;GO:0009786|regulation of asymmetric cell division;GO:0031647|regulation of protein stability;GO:0045176|apical protein localization;GO:0060487|lung epithelial cell differentiation;","GO:0005886|plasma membrane;GO:0005938|cell cortex;GO:0032991|protein-containing complex;GO:0045177|apical part of cell;GO:0045179|apical cortex;","GO:0008093|cytoskeletal adaptor activity;GO:0019904|protein domain specific binding;GO:0030674|protein binding, bridging;",".","."]
["ENSRNOG00000032375",11,0.925487955,3,0.192991315,4.795490187,2.261678293,0.007611821,0.004945727,"up","yes","Capn13","protein_coding","chr6:22071845-22166850:+","gi|68341951|ref|NP_001020304.1|",3523,0,"calpain-13 [Rattus norvegicus]","gi|68341950|ref|NM_001025133.1|",2573,0,"Rattus norvegicus calpain 13 (Capn13), mRNA","Q5BK10",1361,0,"Calpain-13",".",".",".",".","pfam00648","Peptidase_C2","Calpain family cysteine protease.","GO:0006508|proteolysis;GO:0043066|negative regulation of apoptotic process;","GO:0005737|cytoplasm;","GO:0004198|calcium-dependent cysteine-type endopeptidase activity;GO:0005509|calcium ion binding;","K08581","CAPN13; calpain-13 [EC:3.4.22.-]"]
["ENSRNOG00000054603",11,0.925487955,3,0.192991315,4.795490187,2.261678293,0.007611821,0.004945727,"up","yes","Pacsin1","protein_coding","chr20:5719857-5765313:+","gi|8393896|ref|NP_058990.1|",1750,0,"protein kinase C and casein kinase substrate in neurons protein 1 [Rattus norvegicus]","gi|8393895|ref|NM_017294.1|",1231,0,"Rattus norvegicus protein kinase C and casein kinase substrate in neurons 1 (Pacsin1), mRNA","Q9Z0W5",678,0,"Protein kinase C and casein kinase substrate in neurons protein 1",".",".",".",".","pfam14604","SH3_9","Variant SH3 domain.","GO:0007010|cytoskeleton organization;GO:0007015|actin filament organization;GO:0030100|regulation of endocytosis;GO:0045806|negative regulation of endocytosis;GO:0048488|synaptic vesicle endocytosis;GO:0048666|neuron development;GO:0048812|neuron projection morphogenesis;GO:0072657|protein localization to membrane;GO:0072659|protein localization to plasma membrane;GO:0097320|plasma membrane tubulation;GO:0099149|regulation of postsynaptic neurotransmitter receptor internalization;GO:1900006|positive regulation of dendrite development;","GO:0005737|cytoplasm;GO:0005768|endosome;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0030137|COPI-coated vesicle;GO:0030659|cytoplasmic vesicle membrane;GO:0032587|ruffle membrane;GO:0043005|neuron projection;GO:0043195|terminal bouton;GO:0043679|axon terminus;GO:0045202|synapse;GO:0048471|perinuclear region of cytoplasm;GO:0098684|photoreceptor ribbon synapse;GO:0098833|presynaptic endocytic zone;GO:0098839|postsynaptic density membrane;GO:0098978|glutamatergic synapse;","GO:0005515|protein binding;GO:0005543|phospholipid binding;GO:0008092|cytoskeletal protein binding;GO:0042802|identical protein binding;","K20123","PACSIN; protein kinase C and casein kinase substrate in neurons protein"]
["ENSRNOG00000059303",11,0.925487955,3,0.192991315,4.795490187,2.261678293,0.007611821,0.004945727,"up","yes","ENSRNOG00000059303","protein_coding","chr1:199035912-199062917:+","gi|564298666|ref|XP_006223644.1|",2013,0,"PREDICTED: actin-like isoform X1 [Rattus norvegicus]","gi|672014535|ref|XM_006223582.2|",1508,0,"PREDICTED: Rattus norvegicus actin-like (LOC102552318), transcript variant X1, mRNA","P53492",387,{"v":8e-129,"d":"8.00E-129"},"Actin-7","YFL039c",377,{"v":7E-126,"d":"7.00E-126"},"COG5277","pfam00022","Actin","Actin.",".",".",".",".","."]
["ENSRNOG00000005968",14,1.177893761,5,0.321652191,3.662010688,1.872636002,0.007658078,0.00497163,"up","yes","Hoxa2","protein_coding","chr4:81262768-81265044:-","gi|488599464|ref|XP_004484860.1|",1530,0,"PREDICTED: homeobox protein Hox-A2 [Dasypus novemcinctus]","gi|672049746|ref|XM_008762936.1|",1634,0,"PREDICTED: Rattus norvegicus homeobox A2 (Hoxa2), mRNA","P31246",580,0,"Homeobox protein Hox-A2",".",".",".",".","pfam00046","Homeobox","Homeobox domain.",".",".",".","K09302","HOX_2; homeobox protein HoxA/B2"]
["ENSRNOG00000021159",14,1.177893761,5,0.321652191,3.662010688,1.872636002,0.007658078,0.00497163,"up","yes","ENSRNOG00000021159","protein_coding","chr9:1154987-1155443:+","gi|293349609|ref|XP_002727201.1|",380,{"v":6e-45,"d":"6.00E-45"},"PREDICTED: 40S ribosomal protein S27-like [Rattus norvegicus]","gi|298915980|emb|FQ222911.1|",310,{"v":4E-160,"d":"4.00E-160"},"Rattus norvegicus TL0ADA17YP11 mRNA sequence","Q71TY3",143,{"v":2e-43,"d":"2.00E-43"},"40S ribosomal protein S27","SPBC1685.10",111,{"v":1e-31,"d":"1.00E-31"},"COG2051","pfam01667","Ribosomal_S27e","Ribosomal protein S27.","GO:0000028|ribosomal small subunit assembly;GO:0006412|translation;","GO:0022627|cytosolic small ribosomal subunit;","GO:0003723|RNA binding;GO:0003735|structural constituent of ribosome;","K02978","RP-S27e, RPS27; small subunit ribosomal protein S27e"]
["ENSRNOG00000002904",23,1.935111179,12,0.771965258,2.506733507,1.32580863,0.007801762,0.005051658,"up","yes","Arr3","protein_coding","chrX:65698699-65712153:+","gi|300253228|ref|NP_001177922.1|",1838,0,"arrestin-C [Rattus norvegicus]","gi|672087601|ref|XM_006257053.2|",1193,0,"PREDICTED: Rattus norvegicus arrestin 3, retinal (X-arrestin) (Arr3), transcript variant X1, mRNA","Q9EQP6",690,0,"Arrestin-C",".",".",".",".","pfam00339","Arrestin_N","Arrestin (or S-antigen), N-terminal domain. Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.","GO:0001932|regulation of protein phosphorylation;GO:0002031|G protein-coupled receptor internalization;GO:0006897|endocytosis;GO:0007165|signal transduction;GO:0007601|visual perception;GO:0009968|negative regulation of signal transduction;","GO:0001750|photoreceptor outer segment;GO:0001917|photoreceptor inner segment;GO:0045202|synapse;","GO:0001664|G protein-coupled receptor binding;GO:0002046|opsin binding;GO:0005515|protein binding;GO:0019904|protein domain specific binding;GO:0051219|phosphoprotein binding;","K13801","ARR3; arrestin-C"]
["ENSRNOG00000004861",23,1.935111179,12,0.771965258,2.506733507,1.32580863,0.007801762,0.005051658,"up","yes","Itga4","protein_coding","chr3:64163085-64233715:+","gi|157819949|ref|NP_001101207.1|",5493,0,"integrin alpha-4 [Rattus norvegicus]","gi|157819948|ref|NM_001107737.1|",3733,0,"Rattus norvegicus integrin subunit alpha 4 (Itga4), mRNA","Q00651",1978,0,"Integrin alpha-4",".",".",".",".","pfam08441","Integrin_alpha2","Integrin alpha. This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.","GO:0001974|blood vessel remodeling;GO:0002687|positive regulation of leukocyte migration;GO:0003366|cell-matrix adhesion involved in ameboidal cell migration;GO:0007155|cell adhesion;GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007159|leukocyte cell-cell adhesion;GO:0007160|cell-matrix adhesion;GO:0007229|integrin-mediated signaling pathway;GO:0007507|heart development;GO:0016477|cell migration;GO:0033631|cell-cell adhesion mediated by integrin;GO:0034113|heterotypic cell-cell adhesion;GO:0034446|substrate adhesion-dependent cell spreading;GO:0035987|endodermal cell differentiation;GO:0043113|receptor clustering;GO:0050901|leukocyte tethering or rolling;GO:0050904|diapedesis;GO:0060324|face development;GO:0060385|axonogenesis involved in innervation;GO:0060710|chorio-allantoic fusion;GO:0071345|cellular response to cytokine stimulus;GO:0072678|T cell migration;GO:0090074|negative regulation of protein homodimerization activity;GO:0098657|import into cell;GO:0140039|cell-cell adhesion in response to extracellular stimulus;GO:1903039|positive regulation of leukocyte cell-cell adhesion;GO:1903238|positive regulation of leukocyte tethering or rolling;GO:1904646|cellular response to amyloid-beta;GO:1905564|positive regulation of vascular endothelial cell proliferation;GO:1990138|neuron projection extension;GO:1990771|clathrin-dependent extracellular exosome endocytosis;GO:2000353|positive regulation of endothelial cell apoptotic process;GO:2000406|positive regulation of T cell migration;","GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0030426|growth cone;GO:0034669|integrin alpha4-beta7 complex;GO:0043025|neuronal cell body;GO:0070062|extracellular exosome;","GO:0001968|fibronectin binding;GO:0003823|antigen binding;GO:0005515|protein binding;GO:0019960|C-X3-C chemokine binding;GO:0050839|cell adhesion molecule binding;GO:1990405|protein antigen binding;","K06483","ITGA4, CD49d; integrin alpha 4"]
["ENSRNOG00000014909",23,1.935111179,12,0.771965258,2.506733507,1.32580863,0.007801762,0.005051658,"up","yes","Sh2d5","protein_coding","chr5:150467728-150479955:+","gi|564306334|ref|XP_006225645.1|",2191,0,"PREDICTED: SH2 domain-containing protein 5 isoform X1 [Rattus norvegicus]","gi|564306333|ref|XM_006225583.1|",2616,0,"PREDICTED: Rattus norvegicus SH2 domain containing 5 (Sh2d5), transcript variant X1, mRNA","Q8JZW5",800,0,"SH2 domain-containing protein 5",".",".",".",".","pfam00640","PID","Phosphotyrosine interaction domain (PTB/PID).",".","GO:0014069|postsynaptic density;",".","K23701","SH2D5; SH2 domain-containing protein 5"]
["ENSRNOG00000021996",18,1.514434836,8,0.514643505,2.94268716,1.557134176,0.007914725,0.005116284,"up","yes","Nlrp4","protein_coding","chr1:68089321-68127521:-","gi|685156911|ref|NP_001165635.2|",5052,0,"NLR family, pyrin domain containing 4 [Rattus norvegicus]","gi|685156910|ref|NM_001172164.2|",3387,0,"Rattus norvegicus NLR family, pyrin domain containing 4 (Nlrp4), mRNA","Q3TKR3",1744,0,"NACHT, LRR and PYD domains-containing protein 4C",".",".",".",".","pfam05729","NACHT","NACHT domain. This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.",".",".",".","K22265","NLRP4; NACHT, LRR and PYD domains-containing protein 4"]
["ENSRNOG00000045595",18,1.514434836,8,0.514643505,2.94268716,1.557134176,0.007914725,0.005116284,"up","yes","Tnfsf9","protein_coding","chr9:1944017-1946345:+","gi|31077104|ref|NP_852049.1|",1569,0,"tumor necrosis factor ligand superfamily member 9 [Rattus norvegicus]","gi|31341223|ref|NM_181384.2|",1301,0,"Rattus norvegicus tumor necrosis factor superfamily member 9 (Tnfsf9), mRNA","P41274",486,{"v":5e-170,"d":"5.00E-170"},"Tumor necrosis factor ligand superfamily member 9",".",".",".",".","pfam00229","TNF","TNF(tumor Necrosis Factor) family.","GO:0006955|immune response;GO:0007165|signal transduction;GO:0032729|positive regulation of interferon-gamma production;GO:0032735|positive regulation of interleukin-12 production;GO:0032755|positive regulation of interleukin-6 production;GO:0042104|positive regulation of activated T cell proliferation;GO:0042127|regulation of cell proliferation;GO:0043011|myeloid dendritic cell differentiation;GO:0045585|positive regulation of cytotoxic T cell differentiation;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0005102|signaling receptor binding;GO:0005125|cytokine activity;GO:0005164|tumor necrosis factor receptor binding;GO:0032813|tumor necrosis factor receptor superfamily binding;","K05472","TNFSF9, CD137L; tumor necrosis factor ligand superfamily member 9"]
["ENSRNOG00000063278",18,1.514434836,8,0.514643505,2.94268716,1.557134176,0.007914725,0.005116284,"up","yes","ENSRNOG00000063278","protein_coding","chrX:117620634-117621287:-","gi|531171|gb|AAA86463.1|",999,{"v":3e-135,"d":"3.00E-135"},"Csa-19 [Homo sapiens]","gi|37231658|gb|BC058468.1|",618,0,"Rattus norvegicus ribosomal protein L10A, mRNA (cDNA clone MGC:72800 IMAGE:6919792), complete cds","P62907",389,{"v":1E-136,"d":"1.00E-136"},"60S ribosomal protein L10a","SPCC1183.08c",251,{"v":7e-83,"d":"7.00E-83"},"COG0081","pfam00687","Ribosomal_L1","Ribosomal protein L1p/L10e family. This family includes prokaryotic L1 and eukaryotic L10.",".",".",".",".","."]
["ENSRNOG00000066075",18,1.514434836,8,0.514643505,2.94268716,1.557134176,0.007914725,0.005116284,"up","yes","ENSRNOG00000066075","lncRNA","chr6:57316295-57317897:-","gi|149036607|gb|EDL91225.1|",200,{"v":8e-16,"d":"8.00E-16"},"rCG56442 [Rattus norvegicus]","gi|30061464|gb|AC123855.4|",390,0,"Mus musculus BAC clone RP23-328J17 from chromosome 12, complete sequence",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["ENSRNOG00000070104",18,1.514434836,8,0.514643505,2.94268716,1.557134176,0.007914725,0.005116284,"up","yes","ENSRNOG00000070104","lncRNA","chr1:94024973-94034229:+",".",".",".",".","gi|672036384|ref|XM_008759348.1|",2057,0,"PREDICTED: Rattus norvegicus zinc finger protein 819 (Zfp819), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam03782","AMOP","AMOP domain. This domain may have a role in cell adhesion. It is called the AMOP domain after Adhesion associated domain in MUC4 and Other Proteins. This domain is extracellular and contains a number of cysteines that probably form disulphide bridges.",".",".",".",".","."]
["ENSRNOG00000020148",24,2.019246448,13,0.836295696,2.414512542,1.271731957,0.008502246,0.005464285,"up","yes","Il4i1","protein_coding","chr1:95295601-95324562:+","gi|293355926|ref|XP_002728790.1|",3208,0,"PREDICTED: L-amino-acid oxidase isoform X2 [Rattus norvegicus]","gi|672036732|ref|XM_006229191.2|",2234,0,"PREDICTED: Rattus norvegicus rCG53598-like (LOC100360621), transcript variant X6, mRNA","O09046",988,0,"L-amino-acid oxidase","BS_yobN",207,{"v":4e-56,"d":"4.00E-56"},"COG1231","pfam01593","Amino_oxidase","Flavin containing amine oxidoreductase. This family consists of various amine oxidases, including maze polyamine oxidase (PAO) and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.","GO:0002819|regulation of adaptive immune response;GO:0002841|negative regulation of T cell mediated immune response to tumor cell;GO:0006559|L-phenylalanine catabolic process;GO:0006569|tryptophan catabolic process;GO:0006572|tyrosine catabolic process;GO:0009063|cellular amino acid catabolic process;GO:0019440|tryptophan catabolic process to indole-3-acetate;GO:0042130|negative regulation of T cell proliferation;GO:0045591|positive regulation of regulatory T cell differentiation;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050868|negative regulation of T cell activation;","GO:0001669|acrosomal vesicle;GO:0001772|immunological synapse;GO:0005576|extracellular region;GO:0097225|sperm midpiece;","GO:0001716|L-amino-acid oxidase activity;GO:0016491|oxidoreductase activity;GO:0046592|polyamine oxidase activity;","K03334","IL4I1; L-amino-acid oxidase [EC:1.4.3.2]"]
["ENSRNOG00000028652",33,2.776463865,21,1.350939202,2.05521008,1.039285871,0.00865731,0.00555073,"up","yes","Map10","protein_coding","chr19:53642156-53644948:+","gi|475807591|ref|NP_001264320.1|",3999,0,"microtubule-associated protein 10 [Rattus norvegicus]","gi|475807590|ref|NM_001277391.1|",2793,0,"Rattus norvegicus microtubule-associated protein 10 (Map10), mRNA","D3ZAP3",1545,0,"Microtubule-associated protein 10",".",".",".",".","pfam14925","HPHLAWLY","Domain of unknown function. Members of this family carry two distinct, highly conserved sequence motifs, CPPPLYYTHL and HPHLAWLY. The family is found in eukaryotes, and the function is not known. This family lies at the C-terminus of members.","GO:0031122|cytoplasmic microtubule organization;GO:0032467|positive regulation of cytokinesis;GO:0032886|regulation of microtubule-based process;GO:0051256|mitotic spindle midzone assembly;GO:0051301|cell division;","GO:0005813|centrosome;GO:0005881|cytoplasmic microtubule;GO:0030496|midbody;GO:0097431|mitotic spindle pole;GO:1990023|mitotic spindle midzone;","GO:0008017|microtubule binding;",".","."]
["ENSRNOG00000050059",33,2.776463865,21,1.350939202,2.05521008,1.039285871,0.00865731,0.00555073,"up","yes","ENSRNOG00000050059","protein_coding","chr12:18869048-18880075:+","gi|672072556|ref|XP_008767328.1|",1159,{"v":5e-155,"d":"5.00E-155"},"PREDICTED: paired immunoglobulin-like type 2 receptor alpha isoform X2 [Rattus norvegicus]","gi|672033485|ref|XM_008758270.1|",1017,0,"PREDICTED: Rattus norvegicus paired immunoglobin-like type 2 receptor alpha (Pilra), mRNA","Q2YFS3",335,{"v":3e-111,"d":"3.00E-111"},"Paired immunoglobulin-like type 2 receptor alpha",".",".",".",".","pfam14610","DUF4448","Protein of unknown function (DUF4448). This is a family of predicted membrane glycoproteins from fungi. However there appears, visually, to be some similarity with the family of GPI-anchored fungal proteins, pfam10342.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000014928",19,1.598570104,9,0.578973944,2.761039805,1.465211687,0.009091023,0.005809086,"up","yes","Apba1","protein_coding","chr1:221363778-221566553:+","gi|672040016|ref|XP_008758534.1|",3974,0,"PREDICTED: amyloid beta A4 precursor protein-binding family A member 1 isoform X1 [Rattus norvegicus]","gi|146149332|ref|NM_031779.2|",3641,0,"Rattus norvegicus amyloid beta precursor protein binding family A member 1 (Apba1), mRNA","O35430",1531,0,"Amyloid-beta A4 precursor protein-binding family A member 1",".",".",".",".","pfam00640","PID","Phosphotyrosine interaction domain (PTB/PID).","GO:0001701|in utero embryonic development;GO:0006886|intracellular protein transport;GO:0007268|chemical synaptic transmission;GO:0007626|locomotory behavior;GO:0010468|regulation of gene expression;GO:0014047|glutamate secretion;GO:0014051|gamma-aminobutyric acid secretion;GO:0016079|synaptic vesicle exocytosis;GO:0035264|multicellular organism growth;GO:0065003|protein-containing complex assembly;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0008021|synaptic vesicle;GO:0016020|membrane;GO:0032991|protein-containing complex;GO:0043197|dendritic spine;GO:0048471|perinuclear region of cytoplasm;GO:0048787|presynaptic active zone membrane;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098978|glutamatergic synapse;","GO:0001540|amyloid-beta binding;GO:0005515|protein binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0030165|PDZ domain binding;GO:0044877|protein-containing complex binding;","K04531","APBA1, X11; amyloid beta A4 precursor protein-binding family A member 1"]
["ENSRNOG00000042747",19,1.598570104,9,0.578973944,2.761039805,1.465211687,0.009091023,0.005809086,"up","yes","Fam72a","protein_coding","chr13:42967578-42984208:+","gi|149058670|gb|EDM09827.1|",716,{"v":1E-89,"d":"1.00E-89"},"rCG45940 [Rattus norvegicus]","gi|1001624570|ref|NM_175382.4|",987,0,"Mus musculus family with sequence similarity 72, member A (Fam72a), mRNA","A1KXW8",277,{"v":7e-90,"d":"7.00E-90"},"Protein FAM72A",".",".",".",".","pfam14976","FAM72","FAM72 protein. This family of proteins is found in eukaryotes. Proteins in this family are typically between 145 and 264 amino acids in length. The function of this family is unknown.","GO:0031552|negative regulation of brain-derived neurotrophic factor-activated receptor activity;GO:0043065|positive regulation of apoptotic process;","GO:0005739|mitochondrion;GO:0005829|cytosol;GO:0016020|membrane;GO:0043231|intracellular membrane-bounded organelle;",".",".","."]
["ENSRNOG00000062492",25,2.103381716,14,0.900626135,2.335466,1.223710442,0.009163622,5.852042E-3,"up","yes","ENSRNOG00000062492","protein_coding","chr4:9947317-9949797:-","gi|71042796|pdb|2CT9|A",997,{"v":2e-126,"d":"2.00E-126"},"Chain A, The Crystal Structure Of Calcineurin B Homologous Proein 1 (Chp1)","gi|672017924|ref|XR_600569.1|",2450,0,"PREDICTED: Rattus norvegicus similar to calcium binding protein P22 (RGD1565588), transcript variant X1, misc_RNA","P61023",387,{"v":7E-128,"d":"7.00E-128"},"Calcineurin B homologous protein 1","YKL190w",119,{"v":3e-29,"d":"3.00E-29"},"COG5126","pfam13499","EF-hand_7","EF-hand domain pair.",".",".",".",".","."]
["ENSRNOG00000020901",9,0.757217418,2,0.128660876,5.88537432,2.557134176,0.009509474,0.006049494,"up","yes","S1pr5","protein_coding","chr8:19786663-19791795:-","gi|564362665|ref|XP_006242725.1|",1399,0,"PREDICTED: sphingosine 1-phosphate receptor 5 isoform X1 [Rattus norvegicus]","gi|31377520|ref|NM_021775.2|",2147,0,"Rattus norvegicus sphingosine-1-phosphate receptor 5 (S1pr5), mRNA","Q9JKM5",543,0,"Sphingosine 1-phosphate receptor 5",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0003376|sphingosine-1-phosphate receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0019222|regulation of metabolic process;GO:0045664|regulation of neuron differentiation;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0038036|sphingosine-1-phosphate receptor activity;","K04295","S1PR5, EDG8; sphingosine 1-phosphate receptor 5"]
["ENSRNOG00000036700",9,0.757217418,2,0.128660876,5.88537432,2.557134176,0.009509474,0.006049494,"up","yes","Fscn2","protein_coding","chr10:105634783-105641322:+","gi|157818957|ref|NP_001100542.1|",2637,0,"fascin-2 [Rattus norvegicus]","gi|157818956|ref|NM_001107072.1|",1710,0,"Rattus norvegicus fascin actin-bundling protein 2, retinal (Fscn2), mRNA","Q32M02",1001,0,"Fascin-2",".",".",".",".","pfam06268","Fascin","Fascin domain. This family consists of several eukaryotic fascin or singed proteins. The fascins are a structurally unique and evolutionarily conserved group of actin cross-linking proteins. Fascins function in the organisation of two major forms of actin-based structures: dynamic, cortical cell protrusions and cytoplasmic microfilament bundles. The cortical structures, which include filopodia, spikes, lamellipodial ribs, oocyte microvilli and the dendrites of dendritic cells, have roles in cell-matrix adhesion, cell interactions and cell migration, whereas the cytoplasmic actin bundles appear to participate in cell architecture.  Dictyostelium hisactophilin, another actin-binding protein, is a submembranous pH sensor that signals slight changes of the H+ concentration to actin by inducing actin polymerization and binding to microfilaments only at pH values below seven. Members of this family are histidine rich, typically contain the repeated motif of HHXH.","GO:0007163|establishment or maintenance of cell polarity;GO:0008150|biological_process;GO:0016477|cell migration;GO:0042462|eye photoreceptor cell development;GO:0051017|actin filament bundle assembly;","GO:0005575|cellular_component;GO:0005737|cytoplasm;GO:0015629|actin cytoskeleton;GO:0032420|stereocilium;","GO:0005515|protein binding;GO:0030674|protein binding, bridging;GO:0051015|actin filament binding;","K17455","FSCN2; fascin2"]
["ENSRNOG00000048148",9,0.757217418,2,0.128660876,5.88537432,2.557134176,0.009509474,0.006049494,"up","yes","ENSRNOG00000048148","protein_coding","chr7:107141903-107143843:+","gi|293348761|ref|XP_001074078.2|",773,{"v":4e-102,"d":"4.00E-102"},"PREDICTED: lymphocyte antigen 6H [Rattus norvegicus]","gi|672022016|ref|XM_001074078.5|",496,0,"PREDICTED: Rattus norvegicus hypothetical protein LOC686432 (LOC686432), transcript variant X1, mRNA","H3BJG9",187,{"v":2e-59,"d":"2.00E-59"},"Lymphocyte antigen 6L",".",".",".",".","pfam00021","UPAR_LY6","u-PAR/Ly-6 domain. This extracellular disulphide bond rich domain is related to pfam00087.",".",".",".",".","."]
["ENSRNOG00000048169",9,0.757217418,2,0.128660876,5.88537432,2.557134176,0.009509474,0.006049494,"up","yes","Tuba8","protein_coding","chr4:154440074-154456917:+","gi|672050904|ref|XP_008761476.1|",2394,0,"PREDICTED: tubulin alpha-8 chain isoform X1 [Rattus norvegicus]","gi|672050903|ref|XM_008763254.1|",1587,0,"PREDICTED: Rattus norvegicus tubulin, alpha 8 (Tuba8), transcript variant X1, mRNA","Q6AY56",892,0,"Tubulin alpha-8 chain","SPBC800.05c",711,0,"COG5023","pfam03953","Tubulin_C","Tubulin C-terminal domain. This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).","GO:0000226|microtubule cytoskeleton organization;GO:0000278|mitotic cell cycle;","GO:0005737|cytoplasm;GO:0005874|microtubule;GO:0015630|microtubule cytoskeleton;","GO:0003924|GTPase activity;GO:0005200|structural constituent of cytoskeleton;GO:0005525|GTP binding;","K07374","TUBA; tubulin alpha"]
["ENSRNOG00000062362",9,0.757217418,2,0.128660876,5.88537432,2.557134176,0.009509474,0.006049494,"up","yes","ENSRNOG00000062362","lncRNA","chr1:87435579-87457050:+","gi|149022070|gb|EDL78964.1|",144,{"v":4e-07,"d":"4.00E-07"},"rCG27106 [Rattus norvegicus]","gi|28604194|gb|AC123805.4|",646,0,"Mus musculus BAC clone RP24-150A12 from chromosome 7, complete sequence",".",".",".",".",".",".",".",".","pfam03154","Atrophin-1","Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.",".",".",".",".","."]
["ENSRNOG00000069592",9,0.757217418,2,0.128660876,5.88537432,2.557134176,0.009509474,0.006049494,"up","yes","ENSRNOG00000069592","lncRNA","chr10:80634842-80649380:-","gi|26352193|dbj|BAC39733.1|",361,{"v":2e-36,"d":"2.00E-36"},"unnamed protein product [Mus musculus]","gi|644990248|tpe|HG981183.1|",755,0,"TPA: Mus musculus long non-coding RNA OTTMUST00000120316.1 (RP23-17C2.4 gene), lincRNA",".",".",".",".",".",".",".",".","pfam09606","Med15","ARC105 or Med15 subunit of Mediator complex non-fungal. The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.",".",".",".",".","."]
["ENSRNOG00000016837",15,1.26202903,6,0.385982629,3.2696524,1.70913727,0.009548167,6.071272E-3,"up","yes","Ckm","protein_coding","chr1:79061456-79071720:+","gi|6978661|ref|NP_036662.1|",1896,0,"creatine kinase M-type [Rattus norvegicus]","gi|560879438|ref|NM_012530.2|",1437,0,"Rattus norvegicus creatine kinase, M-type (Ckm), mRNA","P00564",731,0,"Creatine kinase M-type","CAC3190",73.9,{"v":1E-13,"d":"1.00E-13"},"COG3869","pfam00217","ATP-gua_Ptrans","ATP:guanido phosphotransferase, C-terminal catalytic domain. The substrate binding site is located in the cleft between N and C-terminal domains, but most of the catalytic residues are found in the larger C-terminal domain.","GO:0009408|response to heat;GO:0016310|phosphorylation;GO:0046314|phosphocreatine biosynthetic process;","GO:0005615|extracellular space;GO:0005737|cytoplasm;","GO:0004111|creatine kinase activity;GO:0005524|ATP binding;GO:0016301|kinase activity;","K00933","E2.7.3.2; creatine kinase [EC:2.7.3.2]"]
["ENSRNOG00000038183",15,1.26202903,6,0.385982629,3.2696524,1.70913727,0.009548167,6.071272E-3,"up","yes","Heatr4","protein_coding","chr6:103574366-103612100:-","gi|672056915|ref|XP_006240425.2|",5238,0,"PREDICTED: HEAT repeat-containing protein 4 isoform X1 [Rattus norvegicus]","gi|672056917|ref|XM_006240360.2|",3294,0,"PREDICTED: Rattus norvegicus similar to hypothetical MGC48595 (RGD1566220), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam13646","HEAT_2","HEAT repeats. This family includes multiple HEAT repeats.",".",".","GO:0016491|oxidoreductase activity;","K24813","HEATR4; HEAT repeat-containing protein 4"]
["ENSRNOG00000051534",15,1.26202903,6,0.385982629,3.2696524,1.70913727,0.009548167,6.071272E-3,"up","yes","Prr33","protein_coding","chr1:197644902-197650714:-","gi|109459666|ref|XP_001064406.1|",1750,0,"PREDICTED: proline-rich protein 33 [Rattus norvegicus]","gi|672014503|ref|XM_002725732.4|",2140,0,"PREDICTED: Rattus norvegicus hypothetical protein LOC685580 (LOC685580), transcript variant X1, mRNA","Q8C494",341,{"v":4e-110,"d":"4.00E-110"},"Proline-rich protein 33",".",".",".",".","pfam15485","DUF4643","Domain of unknown function (DUF4643). This family of proteins is found in eukaryotes. Proteins in this family are typically between 254 and 462 amino acids in length.","GO:0009611|response to wounding;",".",".",".","."]
["ENSRNOG00000005650",26,2.187516985,15,0.964956573,2.266958997,1.180758297,0.009783906,0.00620378,"up","yes","Pgf","protein_coding","chr6:104816104-104826685:-","gi|16758378|ref|NP_446047.1|",851,{"v":5e-109,"d":"5.00E-109"},"placenta growth factor precursor [Rattus norvegicus]","gi|56799414|ref|NM_053595.2|",1561,0,"Rattus norvegicus placental growth factor (Pgf), mRNA","Q63434",332,{"v":2e-110,"d":"2.00E-110"},"Placenta growth factor",".",".",".",".","pfam00341","PDGF","PDGF/VEGF domain.","GO:0001658|branching involved in ureteric bud morphogenesis;GO:0001666|response to hypoxia;GO:0001934|positive regulation of protein phosphorylation;GO:0001938|positive regulation of endothelial cell proliferation;GO:0002040|sprouting angiogenesis;GO:0007565|female pregnancy;GO:0008284|positive regulation of cell proliferation;GO:0009410|response to xenobiotic stimulus;GO:0030154|cell differentiation;GO:0031100|animal organ regeneration;GO:0032870|cellular response to hormone stimulus;GO:0038084|vascular endothelial growth factor signaling pathway;GO:0045766|positive regulation of angiogenesis;GO:0048010|vascular endothelial growth factor receptor signaling pathway;GO:0050918|positive chemotaxis;GO:0050930|induction of positive chemotaxis;GO:0051781|positive regulation of cell division;GO:0060688|regulation of morphogenesis of a branching structure;GO:0060754|positive regulation of mast cell chemotaxis;","GO:0005615|extracellular space;GO:0016020|membrane;","GO:0005172|vascular endothelial growth factor receptor binding;GO:0008083|growth factor activity;GO:0042056|chemoattractant activity;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;","K16859","PGF; placenta growth factor"]
["ENSRNOG00000004560",6,0.504811612,0,0.032165219,15.69433152,3.972171675,0.010059969,0.006344838,"up","yes","Cacna1b","protein_coding","chr3:7380922-7546091:-","gi|564339493|ref|XP_006233639.1|",11078,0,"PREDICTED: voltage-dependent N-type calcium channel subunit alpha-1B isoform X9 [Rattus norvegicus]","gi|672044626|ref|XM_006233577.2|",9726,0,"PREDICTED: Rattus norvegicus calcium channel, voltage-dependent, N type, alpha 1B subunit (Cacna1b), transcript variant X9, mRNA","Q02294",4267,0,"Voltage-dependent N-type calcium channel subunit alpha-1B",".",".",".",".","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0001956|positive regulation of neurotransmitter secretion;GO:0006816|calcium ion transport;GO:0007268|chemical synaptic transmission;GO:0007269|neurotransmitter secretion;GO:0007626|locomotory behavior;GO:0008016|regulation of heart contraction;GO:0008217|regulation of blood pressure;GO:0014070|response to organic cyclic compound;GO:0019233|sensory perception of pain;GO:0033574|response to testosterone;GO:0034765|regulation of ion transmembrane transport;GO:0045471|response to ethanol;GO:0048265|response to pain;GO:0050804|modulation of chemical synaptic transmission;GO:0051924|regulation of calcium ion transport;GO:0070509|calcium ion import;GO:0070588|calcium ion transmembrane transport;GO:0099703|induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration;GO:1904645|response to amyloid-beta;","GO:0005886|plasma membrane;GO:0005891|voltage-gated calcium channel complex;GO:0016020|membrane;GO:0016323|basolateral plasma membrane;GO:0030425|dendrite;GO:0032991|protein-containing complex;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0043198|dendritic shaft;GO:0043679|axon terminus;GO:0044306|neuron projection terminus;GO:0060171|stereocilium membrane;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098978|glutamatergic synapse;","GO:0005245|voltage-gated calcium channel activity;GO:0005509|calcium ion binding;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0008022|protein C-terminus binding;GO:0008331|high voltage-gated calcium channel activity;GO:0051721|protein phosphatase 2A binding;GO:0099635|voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels;","K04849","CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B"]
["ENSRNOG00000005049",6,0.504811612,0,0.032165219,15.69433152,3.972171675,0.010059969,0.006344838,"up","yes","Tbr1","protein_coding","chr3:46351213-46361041:+","gi|34328151|ref|NP_033348.2|",3327,0,"T-box brain protein 1 [Mus musculus]","gi|755499123|ref|XM_006499098.2|",3505,0,"PREDICTED: Mus musculus T-box brain gene 1 (Tbr1), transcript variant X1, mRNA","Q64336",1282,0,"T-box brain protein 1",".",".",".",".","pfam00907","T-box","T-box. The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.","GO:0001661|conditioned taste aversion;GO:0001708|cell fate specification;GO:0006357|regulation of transcription by RNA polymerase II;GO:0010092|specification of animal organ identity;GO:0010468|regulation of gene expression;GO:0010975|regulation of neuron projection development;GO:0021764|amygdala development;GO:0021902|commitment of neuronal cell to specific neuron type in forebrain;GO:0021987|cerebral cortex development;GO:0030182|neuron differentiation;GO:0030902|hindbrain development;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:1902667|regulation of axon guidance;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0019901|protein kinase binding;","K10174","TBR1; T-box brain protein 1"]
["ENSRNOG00000005947",6,0.504811612,0,0.032165219,15.69433152,3.972171675,0.010059969,0.006344838,"up","yes","Pde6h","protein_coding","chr4:169857812-169872969:+","gi|149049136|gb|EDM01590.1|",421,{"v":2e-49,"d":"2.00E-49"},"phosphodiesterase 6H, cGMP-specific, cone, gamma, isoform CRA_b [Rattus norvegicus]","gi|672051307|ref|XM_006237558.2|",410,0,"PREDICTED: Rattus norvegicus phosphodiesterase 6H, cGMP-specific, cone, gamma (Pde6h), transcript variant X1, mRNA","P61250",96.3,{"v":7e-24,"d":"7.00E-24"},"Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma",".",".",".",".","pfam04868","PDE6_gamma","Retinal cGMP phosphodiesterase, gamma subunit. Retinal rod and cone cGMP phosphodiesterases function as the effector enzymes in the vertebrate visual transduction cascade. This family represents the inhibitory gamma subunit, which is also expressed outside retinal tissues and has been shown to interact with the G-protein-coupled receptor kinase 2 signalling system to regulate the epidermal growth factor- and thrombin-dependent stimulation of p42/p44 mitogen-activated protein kinase in human embryonic kidney 293 cells.","GO:0007601|visual perception;GO:0008150|biological_process;GO:0043410|positive regulation of MAPK cascade;GO:0045742|positive regulation of epidermal growth factor receptor signaling pathway;GO:0045745|positive regulation of G protein-coupled receptor signaling pathway;","GO:0005575|cellular_component;GO:0042622|photoreceptor outer segment membrane;","GO:0003674|molecular_function;GO:0030553|cGMP binding;GO:0047555|3',5'-cyclic-GMP phosphodiesterase activity;","K13760","PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma"]
["ENSRNOG00000006132",6,0.504811612,0,0.032165219,15.69433152,3.972171675,0.010059969,0.006344838,"up","yes","Fam71f1","protein_coding","chr4:57920790-57938591:+","gi|564346130|ref|XP_006236286.1|",1553,0,"PREDICTED: protein FAM71F1 isoform X2 [Rattus norvegicus]","gi|672049263|ref|XM_006236223.2|",1750,0,"PREDICTED: Rattus norvegicus family with sequence similarity 71, member F1 (Fam71f1), transcript variant X1, mRNA","Q68FV5",597,0,"Protein FAM71F1",".",".",".",".","pfam12480","DUF3699","Protein of unknown function (DUF3699). This domain family is found in eukaryotes, and is approximately 80 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000012759",6,0.504811612,0,0.032165219,15.69433152,3.972171675,0.010059969,0.006344838,"up","yes","Col19a1","protein_coding","chr9:26675391-27022106:-","gi|672023833|ref|XP_008756211.1|",1863,0,"PREDICTED: collagen alpha-1(XIX) chain isoform X1 [Rattus norvegicus]","gi|672023832|ref|XM_008757989.1|",6082,0,"PREDICTED: Rattus norvegicus collagen, type XIX, alpha 1 (Col19a1), transcript variant X1, mRNA","Q0VF58",620,0,"Collagen alpha-1(XIX) chain",".",".",".",".","pfam01391","Collagen","Collagen triple helix repeat (20 copies). Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxyproline. Collagens are post translationally modified by proline hydroxylase to form the hydroxyproline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure.","GO:0007519|skeletal muscle tissue development;GO:0008150|biological_process;GO:0030198|extracellular matrix organization;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0031012|extracellular matrix;","GO:0003674|molecular_function;GO:0005201|extracellular matrix structural constituent;","K24340","COL19A; collagen type XIX alpha"]
["ENSRNOG00000013334",6,0.504811612,0,0.032165219,15.69433152,3.972171675,0.010059969,0.006344838,"up","yes","Clca5","protein_coding","chr2:233796575-233818949:-","gi|61557272|ref|NP_001013220.1|",4491,0,"chloride channel calcium activated 2 precursor [Rattus norvegicus]","gi|402692916|ref|NM_001013202.2|",3116,0,"Rattus norvegicus chloride channel calcium activated 2 (Clca2), mRNA","Q9QX15",1446,0,"Calcium-activated chloride channel regulator 3A-1","sll0103",52,{"v":8e-06,"d":"8.00E-06"},"COG2304","pfam08434","CLCA_N","Calcium-activated chloride channel. The CLCA family of calcium-activated chloride channels has been identified in many epithelial and endothelial cell types as well as in smooth muscle cells and has four or five putative transmembrane regions. Additionally to their role as chloride channels some CLCA proteins function as adhesion molecules and may also have roles as tumor suppressors. The domain described here is found at the N-terminus of CLCAs.","GO:0006508|proteolysis;GO:0006821|chloride transport;GO:0015698|inorganic anion transport;","GO:0005887|integral component of plasma membrane;","GO:0005229|intracellular calcium activated chloride channel activity;GO:0008237|metallopeptidase activity;GO:0046872|metal ion binding;","K05030","CLCA3_4; calcium-activated chloride channel regulator 3/4"]
["ENSRNOG00000018557",6,0.504811612,0,0.032165219,15.69433152,3.972171675,0.010059969,0.006344838,"up","yes","Cdh22","protein_coding","chr3:153845787-153970588:-","gi|139948303|ref|NP_062034.2|",3625,0,"cadherin-22 precursor [Rattus norvegicus]","gi|139948302|ref|NM_019161.2|",3231,0,"Rattus norvegicus cadherin 22 (Cdh22), mRNA","Q63315",1400,0,"Cadherin-22",".",".",".",".","pfam01049","Cadherin_C","Cadherin cytoplasmic region. Cadherins are vital in cell-cell adhesion during tissue differentiation. Cadherins are linked to the cytoskeleton by catenins. Catenins bind to the cytoplasmic tail of the cadherin. Cadherins cluster to form foci of homophilic binding units. A key determinant to the strength of the binding that it is mediated by cadherins is the juxtamembrane region of the cadherin. This region induces clustering and also binds to the protein p120ctn.","GO:0000902|cell morphogenesis;GO:0007043|cell-cell junction assembly;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007275|multicellular organism development;GO:0007420|brain development;GO:0016339|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0034332|adherens junction organization;GO:0098742|cell-cell adhesion via plasma-membrane adhesion molecules;","GO:0005912|adherens junction;GO:0016021|integral component of membrane;GO:0016342|catenin complex;","GO:0005509|calcium ion binding;GO:0045296|cadherin binding;","K06812","CDH22; cadherin 22"]
["ENSRNOG00000020420",6,0.504811612,0,0.032165219,15.69433152,3.972171675,0.010059969,0.006344838,"up","yes","Pklr","protein_coding","chr2:174543039-174551870:+","gi|185134818|ref|NP_036756.3|",2851,0,"pyruvate kinase PKLR [Rattus norvegicus]","gi|185134817|ref|NM_012624.3|",2902,0,"Rattus norvegicus pyruvate kinase, liver and RBC (Pklr), mRNA","P12928",1102,0,"Pyruvate kinase PKLR","SPAC4H3.10c",518,{"v":3e-170,"d":"3.00E-170"},"COG0469","pfam00224","PK","Pyruvate kinase, barrel domain. This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.","GO:0001666|response to hypoxia;GO:0005975|carbohydrate metabolic process;GO:0006096|glycolytic process;GO:0006754|ATP biosynthetic process;GO:0007584|response to nutrient;GO:0009408|response to heat;GO:0009749|response to glucose;GO:0010038|response to metal ion;GO:0010226|response to lithium ion;GO:0032869|cellular response to insulin stimulus;GO:0033198|response to ATP;GO:0042866|pyruvate biosynthetic process;GO:0051591|response to cAMP;GO:0051707|response to other organism;GO:0071872|cellular response to epinephrine stimulus;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0000287|magnesium ion binding;GO:0004743|pyruvate kinase activity;GO:0005524|ATP binding;GO:0016301|kinase activity;GO:0030955|potassium ion binding;","K12406","PKLR; pyruvate kinase isozymes R/L [EC:2.7.1.40]"]
["ENSRNOG00000021763",6,0.504811612,0,0.032165219,15.69433152,3.972171675,0.010059969,0.006344838,"up","yes","Ffar4","protein_coding","chr1:235873576-235891597:+","gi|114052953|ref|NP_001040553.1|",1673,0,"free fatty acid receptor 4 [Rattus norvegicus]","gi|114052952|ref|NM_001047088.1|",1379,0,"Rattus norvegicus free fatty acid receptor 4 (Ffar4), mRNA","Q2AC31",649,0,"Free fatty acid receptor 4",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001818|negative regulation of cytokine production;GO:0006954|inflammatory response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0010827|regulation of glucose transmembrane transport;GO:0032691|negative regulation of interleukin-1 beta production;GO:0036321|ghrelin secretion;GO:0043066|negative regulation of apoptotic process;GO:0043950|positive regulation of cAMP-mediated signaling;GO:0045444|fat cell differentiation;GO:0045669|positive regulation of osteoblast differentiation;GO:0046879|hormone secretion;GO:0050728|negative regulation of inflammatory response;GO:0050872|white fat cell differentiation;GO:0050873|brown fat cell differentiation;GO:0050912|detection of chemical stimulus involved in sensory perception of taste;GO:0070094|positive regulation of glucagon secretion;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0090275|negative regulation of somatostatin secretion;GO:0090336|positive regulation of brown fat cell differentiation;GO:0120162|positive regulation of cold-induced thermogenesis;","GO:0005765|lysosomal membrane;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005929|cilium;GO:0010008|endosome membrane;GO:0030139|endocytic vesicle;GO:0060170|ciliary membrane;","GO:0004930|G protein-coupled receptor activity;GO:0005504|fatty acid binding;GO:0008527|taste receptor activity;GO:1990763|arrestin family protein binding;","K08425","FFAR4, GPR120; free fatty acid receptor 4"]
["ENSRNOG00000031785",6,0.504811612,0,0.032165219,15.69433152,3.972171675,0.010059969,0.006344838,"up","yes","Krt76","protein_coding","chr7:133016992-133025496:-","gi|57012372|ref|NP_001008805.1|",1996,0,"keratin, type II cytoskeletal 2 oral [Rattus norvegicus]","gi|57012371|ref|NM_001008805.1|",1746,0,"Rattus norvegicus keratin 76, type II (Krt76), mRNA","Q3UV17",674,0,"Keratin, type II cytoskeletal 2 oral",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0007010|cytoskeleton organization;GO:0008544|epidermis development;GO:0043473|pigmentation;GO:0045103|intermediate filament-based process;GO:0048733|sebaceous gland development;","GO:0005882|intermediate filament;GO:0045095|keratin filament;","GO:0005200|structural constituent of cytoskeleton;","K07605","KRT2; type II keratin, basic"]
["ENSRNOG00000040300",6,0.504811612,0,0.032165219,15.69433152,3.972171675,0.010059969,0.006344838,"up","yes","ENSRNOG00000040300","protein_coding","chr1:1807644-1812755:-","gi|239787120|ref|NP_001155163.1|",1925,0,"Rae-1-like protein [Rattus norvegicus]","gi|239787119|ref|NM_001161691.1|",1110,0,"Rattus norvegicus similar to retinoic acid early transcript 1L (Rrlt), mRNA","O08604",192,{"v":2e-56,"d":"2.00E-56"},"Retinoic acid early-inducible protein 1-gamma",".",".",".",".","pfam14586","MHC_I_2","Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2. Members of this family are known as retinoic-acid-inducible proteins. They are ligands for the activating immunoreceptor NKG2D, which is widely expressed on natural killer cells, T cells, and macrophages.","GO:0001913|T cell mediated cytotoxicity;GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target;GO:0006955|immune response;GO:0042267|natural killer cell mediated cytotoxicity;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;","GO:0005615|extracellular space;GO:0009897|external side of plasma membrane;GO:0031225|anchored component of membrane;GO:0044214|spanning component of plasma membrane;","GO:0046703|natural killer cell lectin-like receptor binding;","K07987","RAET1; retinoic acid early transcript 1"]
["ENSRNOG00000046758",6,0.504811612,0,0.032165219,15.69433152,3.972171675,0.010059969,0.006344838,"up","yes","Tmem217","protein_coding","chr20:7592627-7619111:-","gi|109509869|ref|XP_001078767.1|",1013,{"v":8e-135,"d":"8.00E-135"},"PREDICTED: transmembrane protein 217-like [Rattus norvegicus]","gi|672086048|ref|XM_003751936.3|",751,0,"PREDICTED: Rattus norvegicus hypothetical protein LOC687483 (LOC687483), transcript variant X2, mRNA","Q8N7C4",227,{"v":2E-70,"d":"2.00E-70"},"Transmembrane protein 217",".",".",".",".","pfam15049","DUF4534","Protein of unknown function (DUF4534). This family of proteins is functionally uncharacterized. This family of proteins is found in mammals. Proteins in this family are typically between 170 and 190 amino acids in length. The protein includes the human integral membrane TMEM217 protein.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000054013",6,0.504811612,0,0.032165219,15.69433152,3.972171675,0.010059969,0.006344838,"up","yes","Clec4g","protein_coding","chr12:1780371-1784985:-","gi|672072155|ref|XP_008767238.1|",1319,{"v":2E-179,"d":"2.00E-179"},"PREDICTED: LOW QUALITY PROTEIN: C-type lectin domain family 4 member G isoform X2 [Rattus norvegicus]","gi|672072154|ref|XM_008769016.1|",1134,0,"PREDICTED: Rattus norvegicus C-type lectin domain family 4, member G (Clec4g), transcript variant X2, mRNA","Q8BNX1",483,{"v":2E-169,"d":"2.00E-169"},"C-type lectin domain family 4 member G",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0002710|negative regulation of T cell mediated immunity;GO:0042130|negative regulation of T cell proliferation;GO:0046718|viral entry into host cell;GO:1903902|positive regulation of viral life cycle;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;","GO:0001618|virus receptor activity;GO:0005537|mannose binding;GO:0030247|polysaccharide binding;GO:0070061|fructose binding;GO:0097367|carbohydrate derivative binding;","K10061","CLEC4G; C-type lectin superfamily 4 member G"]
["ENSRNOG00000056400",6,0.504811612,0,0.032165219,15.69433152,3.972171675,0.010059969,0.006344838,"up","yes","Hhipl2","protein_coding","chr13:95054694-95074608:+","gi|109498329|ref|XP_229754.4|",3748,0,"PREDICTED: HHIP-like protein 2 [Rattus norvegicus]","gi|672027470|ref|XM_001064362.4|",2151,0,"PREDICTED: Rattus norvegicus hedgehog interacting protein-like 2 (Hhipl2), mRNA","Q9D2G9",1332,0,"HHIP-like protein 2","slr1608",103,{"v":2e-22,"d":"2.00E-22"},"COG2133","pfam07995","GSDH","Glucose / Sorbosone dehydrogenase. Members of this family are glucose/sorbosone dehydrogenases that possess a beta-propeller fold.",".",".","GO:0003824|catalytic activity;","K25557","HHIPL; HHIP-like protein"]
["ENSRNOG00000062536",6,0.504811612,0,0.032165219,15.69433152,3.972171675,0.010059969,0.006344838,"up","yes","ENSRNOG00000062536","lncRNA","chr5:144238211-144239578:+",".",".",".",".","gi|22531402|emb|AL669981.11|",634,0,"Mouse DNA sequence from clone RP23-335B9 on chromosome 4, complete sequence",".",".",".",".",".",".",".",".","pfam03925","SeqA","SeqA protein. The binding of SeqA protein to hemimethylated GATC sequences is important in the negative modulation of chromosomal initiation at oriC, and in the formation of SeqA foci necessary for Escherichia coli chromosome segregation. SeqA tetramers are able to aggregate or multimerize in a reversible, concentration-dependent manner. Apart from its function in the control of DNA replication, SeqA may also be a specific transcription factor.",".",".",".",".","."]
["ENSRNOG00000062843",6,0.504811612,0,0.032165219,15.69433152,3.972171675,0.010059969,0.006344838,"up","yes","ENSRNOG00000062843","lncRNA","chr20:9330630-9334059:-",".",".",".",".","gi|62868185|gb|AC154652.2|",118,{"v":8e-53,"d":"8.00E-53"},"Mus musculus BAC clone RP24-261L18 from chromosome 17, complete sequence",".",".",".",".",".",".",".",".","pfam07672","MFS_Mycoplasma","Mycoplasma MFS transporter. These proteins share some similarity with members of the Major Facilitator Superfamily (MFS).",".",".",".",".","."]
["ENSRNOG00000064589",6,0.504811612,0,0.032165219,15.69433152,3.972171675,0.010059969,0.006344838,"up","yes","ENSRNOG00000064589","protein_coding","chr11:81906179-81911931:+","gi|204870|gb|AAA41420.1|",555,{"v":7e-68,"d":"7.00E-68"},"Ig lambda-chain C2-region, partial [Rattus norvegicus]","gi|672026350|ref|XM_008758339.1|",452,0,"PREDICTED: Rattus norvegicus immunoglobulin lambda-like polypeptide 5-like (LOC680329), mRNA","P20767",216,{"v":2e-68,"d":"2.00E-68"},"Ig lambda-2 chain C region",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.",".",".",".",".","."]
["ENSRNOG00000065788",6,0.504811612,0,0.032165219,15.69433152,3.972171675,0.010059969,0.006344838,"up","yes","Zfp683","protein_coding","chr5:146278978-146285000:+","gi|672020004|ref|XP_002726647.2|",2352,0,"PREDICTED: zinc finger protein 683 [Rattus norvegicus]","gi|672020003|ref|XM_002726601.3|",1434,0,"PREDICTED: Rattus norvegicus zinc finger protein 683 (Zfp683), mRNA","I7HJS4",720,0,"Tissue-resident T-cell transcription regulator protein ZNF683",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.",".",".",".",".","."]
["ENSRNOG00000068429",6,0.504811612,0,0.032165219,15.69433152,3.972171675,0.010059969,0.006344838,"up","yes","ENSRNOG00000068429","lncRNA","chr3:105704386-105721406:+",".",".",".",".","gi|672017182|ref|XR_600306.1|",418,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102548045 (LOC102548045), transcript variant X1, ncRNA",".",".",".",".",".",".",".",".","pfam04579","Keratin_matx","Keratin, high-sulphur matrix protein. Family of Keratin, high-sulfur matrix proteins. The keratin products of mammalian epidermal derivatives such as wool and hair consist of microfibrils embedded in a rigid matrix of other proteins. The matrix proteins include the high-sulphur and high-tyrosine keratins, having molecular weights of 6-20 kDa, whereas microfibrils contain the larger, low-sulphur keratins (40-56 kDa).",".",".",".",".","."]
["ENSRNOG00000047940",20,1.682705373,10,0.643304382,2.61572192,1.387209175,0.010217458,0.00642185,"up","yes","Mmp28","protein_coding","chr10:68241138-68264866:-","gi|120586977|ref|NP_001073357.1|",2548,0,"matrix metalloproteinase-28 precursor [Rattus norvegicus]","gi|49615113|gb|AC119615.7|",3022,0,"Rattus norvegicus 10 NOVECTOR CH230-502G21 (Children's Hospital Oakland Research Institute) complete sequence","Q9H239",820,0,"Matrix metalloproteinase-28",".",".",".",".","pfam00413","Peptidase_M10","Matrixin. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.","GO:0006508|proteolysis;GO:0010760|negative regulation of macrophage chemotaxis;GO:0030198|extracellular matrix organization;GO:0030574|collagen catabolic process;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0031012|extracellular matrix;","GO:0004222|metalloendopeptidase activity;GO:0008270|zinc ion binding;","K08006","MMP28; matrix metalloproteinase-28 (epilysin) [EC:3.4.24.-]"]
["ENSRNOG00000064076",27,2.271652253,16,1.029287011,2.20701537,1.142096677,0.010362146,0.006509783,"up","yes","ENSRNOG00000064076","lncRNA","chr3:68765037-68766837:+",".",".",".",".","gi|23304112|emb|AL844166.6|",379,0,"Mouse DNA sequence from clone RP23-107K21 on chromosome 2, complete sequence",".",".",".",".",".",".",".",".","pfam10441","Urb2","Urb2/Npa2 family. This family includes the Urb2 protein from yeast that are involved in ribosome biogenesis.",".",".",".",".","."]
["ENSRNOG00000016632",7,0.588946881,1,0.064330438,9.155026721,3.194564097,0.010519497,0.006592661,"up","yes","Dsg3","protein_coding","chr18:11798900-11830818:+","gi|672082682|ref|XP_008770156.1|",5086,0,"PREDICTED: desmoglein-3 isoform X1 [Rattus norvegicus]","gi|672082681|ref|XM_008771934.1|",2739,0,"PREDICTED: Rattus norvegicus desmoglein 3 (Dsg3), transcript variant X1, mRNA","O35902",1717,0,"Desmoglein-3",".",".",".",".","pfam00028","Cadherin","Cadherin domain.","GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0098609|cell-cell adhesion;","GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0016021|integral component of membrane;GO:0030057|desmosome;","GO:0005509|calcium ion binding;","K07598","DSG3; desmoglein 3"]
["ENSRNOG00000017842",7,0.588946881,1,0.064330438,9.155026721,3.194564097,0.010519497,0.006592661,"up","yes","Scnn1g","protein_coding","chr1:176304942-176338816:+","gi|149068028|gb|EDM17580.1|",3317,0,"sodium channel, nonvoltage-gated 1 gamma [Rattus norvegicus]","gi|25742789|ref|NM_017046.1|",2936,0,"Rattus norvegicus sodium channel epithelial 1 gamma subunit (Scnn1g), mRNA","P37091",1280,0,"Amiloride-sensitive sodium channel subunit gamma",".",".",".",".","pfam00858","ASC","Amiloride-sensitive sodium channel.","GO:0001666|response to hypoxia;GO:0006814|sodium ion transport;GO:0035313|wound healing, spreading of epidermal cells;GO:0035725|sodium ion transmembrane transport;GO:0050891|multicellular organismal water homeostasis;GO:0050909|sensory perception of taste;GO:0055078|sodium ion homeostasis;GO:1904045|cellular response to aldosterone;","GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0034706|sodium channel complex;GO:0070062|extracellular exosome;GO:0098797|plasma membrane protein complex;","GO:0005216|ion channel activity;GO:0005272|sodium channel activity;GO:0005515|protein binding;GO:0015081|sodium ion transmembrane transporter activity;GO:0015280|ligand-gated sodium channel activity;GO:0050699|WW domain binding;","K04827","SCNN1G, ENACG; amiloride-sensitive sodium channel subunit gamma"]
["ENSRNOG00000028427",7,0.588946881,1,0.064330438,9.155026721,3.194564097,0.010519497,0.006592661,"up","yes","AABR07030524.1","protein_coding","chr10:88602453-88602827:+","gi|81863716|sp|Q6EIX2.1|TIM16_RAT",385,{"v":2E-45,"d":"2.00E-45"},"RecName: Full=Mitochondrial import inner membrane translocase subunit TIM16; AltName: Full=Mitochondria-associated granulocyte macrophage CSF-signaling molecule; AltName: Full=Presequence translocated-associated motor subunit PAM16","gi|676260327|ref|NG_008609.3|",283,{"v":4e-145,"d":"4.00E-145"},"Rattus norvegicus mitochondria-associated protein involved in granulocyte-macrophage colony-stimulating factor signal transduction, pseudogene 1 (Magmas-ps1) on chromosome 10","Q6EIX2",152,{"v":6e-47,"d":"6.00E-47"},"Mitochondrial import inner membrane translocase subunit TIM16",".",".",".",".","pfam03656","Pam16","Pam16. The Pam16 protein is the fifth essential subunit of the pre-sequence translocase-associated protein import motor (PAM). In Saccharomyces cerevisiae, Pam16 is required for preprotein translocation into the matrix, but not for protein insertion into the inner membrane. Pam16 has a degenerate J domain. J-domain proteins play important regulatory roles as co-chaperones, recruiting Hsp70 partners and accelerating the ATP-hydrolysis step of the chaperone cycle. Pam16's J-like domain strongly interacts with Pam18's J domain, leading to a productive interaction of Pam18 with mtHsp70 at the mitochondria import channel. Pam18 stimulates the ATPase activity of mtHsp70.","GO:0001503|ossification;GO:0030150|protein import into mitochondrial matrix;","GO:0005744|TIM23 mitochondrial import inner membrane translocase complex;",".",".","."]
["ENSRNOG00000042470",7,0.588946881,1,0.064330438,9.155026721,3.194564097,0.010519497,0.006592661,"up","yes","Eras","protein_coding","chrX:14573987-14578374:+","gi|157820151|ref|NP_001102845.1|",1115,{"v":3e-150,"d":"3.00E-150"},"GTPase ERas [Rattus norvegicus]","gi|157820150|ref|NM_001109375.1|",1066,0,"Rattus norvegicus ES cell expressed Ras (Eras), mRNA","Q7TN89",367,{"v":2E-125,"d":"2.00E-125"},"GTPase ERas",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0007265|Ras protein signal transduction;","GO:0005886|plasma membrane;","GO:0003924|GTPase activity;GO:0005525|GTP binding;GO:0019003|GDP binding;","K17196","ERAS; GTPase Eras"]
["ENSRNOG00000049688",7,0.588946881,1,0.064330438,9.155026721,3.194564097,0.010519497,0.006592661,"up","yes","Mir6334","miRNA","chr3:143883158-143883256:-",".",".",".",".","gi|672047531|ref|XM_006235329.2|",99,{"v":2e-43,"d":"2.00E-43"},"PREDICTED: Rattus norvegicus tumor protein p53 inducible nuclear protein 2 (Tp53inp2), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam11920","DUF3438","Protein of unknown function (DUF3438). This family of proteins are functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 276 to 307 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000061336",7,0.588946881,1,0.064330438,9.155026721,3.194564097,0.010519497,0.006592661,"up","yes","U1","snRNA","chr15:31978334-31978481:-","gi|927196956|ref|XP_013836555.1|",148,{"v":1e-09,"d":"1.00E-09"},"PREDICTED: inactive serine/threonine-protein kinase TEX14 [Sus scrofa]",".",".",".",".",".",".",".",".",".",".",".",".","pfam00491","Arginase","Arginase family.",".",".",".",".","."]
["ENSRNOG00000067260",7,0.588946881,1,0.064330438,9.155026721,3.194564097,0.010519497,0.006592661,"up","yes","ENSRNOG00000067260","lncRNA","chr4:151061589-151065913:+",".",".",".",".","gi|61675712|gb|AC153918.4|",420,0,"Mus musculus BAC RP23-89M16 (Roswell Park Cancer Institute (C57BL/6J Female) Mouse BAC Library) complete sequence",".",".",".",".",".",".",".",".","pfam10034","Dpy19","Q-cell neuroblast polarisation. Dyp-19, formerly known as DUF2211, is a transmembrane domain family that is required to orient the neuroblast cells, QR and QL accurately on the anterior-posterior axis: QL and QR are born in the same anterior-posterior position, but polarise and migrate left-right asymmetrically, QL migrating towards the posterior and QR migrating towards the anterior. It is also required, with unc-40, to express mab-5 correctly in the Q cell descendants. The Dpy-19 protein derives from the C. elegans DUMPY mutant.",".",".",".",".","."]
["ENSRNOG00000068044",7,0.588946881,1,0.064330438,9.155026721,3.194564097,0.010519497,0.006592661,"up","yes","Lypd6","protein_coding","chr3:34496485-34630308:+","gi|392339251|ref|XP_003753769.1|",807,{"v":7e-103,"d":"7.00E-103"},"PREDICTED: ly6/PLAUR domain-containing protein 6 isoform X1 [Rattus norvegicus]","gi|672045524|ref|XM_001053512.5|",1086,0,"PREDICTED: Rattus norvegicus LY6/PLAUR domain containing 6 (Lypd6), transcript variant X2, mRNA","D3ZTT2",315,{"v":2e-104,"d":"2.00E-104"},"Ly6/PLAUR domain-containing protein 6",".",".",".",".","pfam01064","Activin_recp","Activin types I and II receptor domain. This Pfam entry consists of both TGF-beta receptor types. This is an alignment of the hydrophilic cysteine-rich ligand-binding domains, Both receptor types, (type I and II) posses a 9 amino acid cysteine box, with the the consensus CCX{4-5}CN. The type I receptors also possess 7 extracellular residues preceding the cysteine box.",".",".",".",".","."]
["ENSRNOG00000070861",7,0.588946881,1,0.064330438,9.155026721,3.194564097,0.010519497,0.006592661,"up","yes","ENSRNOG00000070861","protein_coding","chr11:64588465-64593327:+","gi|564314491|ref|XP_006221216.1|",546,{"v":2e-69,"d":"2.00E-69"},"PREDICTED: stefin-2-like isoform X1 [Rattus norvegicus]","gi|672026108|ref|XM_006221154.2|",397,0,"PREDICTED: Rattus norvegicus stefin-3-like (LOC100911790), transcript variant X1, mRNA","P35174",163,{"v":1E-50,"d":"1.00E-50"},"Stefin-2",".",".",".",".","pfam00031","Cystatin","Cystatin domain. Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 are related to this family but have not been included.",".",".",".",".","."]
["ENSRNOG00000002667",12,1.009623224,4,0.257321753,3.92358288,1.972171675,0.01059652,0.006634823,"up","yes","Lamc2","protein_coding","chr13:65284664-65344200:-","gi|281371494|ref|NP_001094110.1|",6224,0,"laminin subunit gamma-2 precursor [Rattus norvegicus]","gi|281371493|ref|NM_001100640.1|",5154,0,"Rattus norvegicus laminin subunit gamma 2 (Lamc2), mRNA","Q61092",2204,0,"Laminin subunit gamma-2",".",".",".",".","pfam00052","Laminin_B","Laminin B (Domain IV).","GO:0008045|motor neuron axon guidance;GO:0008150|biological_process;GO:0008284|positive regulation of cell proliferation;GO:0009887|animal organ morphogenesis;GO:0009888|tissue development;GO:0016358|dendrite development;GO:0030335|positive regulation of cell migration;","GO:0005604|basement membrane;GO:0005607|laminin-2 complex;GO:0005610|laminin-5 complex;GO:0005615|extracellular space;GO:0005938|cell cortex;GO:0016020|membrane;GO:0031012|extracellular matrix;GO:0048471|perinuclear region of cytoplasm;","GO:0003674|molecular_function;GO:0005102|signaling receptor binding;GO:0008201|heparin binding;","K06246","LAMC2; laminin, gamma 2"]
["ENSRNOG00000016368",12,1.009623224,4,0.257321753,3.92358288,1.972171675,0.01059652,0.006634823,"up","yes","Ppp1r14c","protein_coding","chr1:39773403-39886956:+","gi|19173802|ref|NP_596916.1|",484,{"v":7e-53,"d":"7.00E-53"},"protein phosphatase 1 regulatory subunit 14C [Rattus norvegicus]","gi|118343645|ref|NM_133425.3|",2770,0,"Rattus norvegicus protein phosphatase 1, regulatory (inhibitor) subunit 14c (Ppp1r14c), mRNA","Q8R4R9",191,{"v":2e-54,"d":"2.00E-54"},"Protein phosphatase 1 regulatory subunit 14C",".",".",".",".","pfam05361","PP1_inhibitor","PKC-activated protein phosphatase-1 inhibitor. Contractility of vascular smooth muscle depends on phosphorylation of myosin light chains, and is modulated by hormonal control of myosin phosphatase activity. Signaling pathways activate kinases such as PKC or Rho-dependent kinases that phosphorylate the myosin phosphatase inhibitor protein called CPI-17. Phosphorylation of CPI-17 at Thr-38 enhances its inhibitory potency 1000-fold, creating a molecular switch for regulating contraction.","GO:0042325|regulation of phosphorylation;GO:0043086|negative regulation of catalytic activity;","GO:0005737|cytoplasm;GO:0012505|endomembrane system;GO:0016020|membrane;","GO:0004865|protein serine/threonine phosphatase inhibitor activity;","K17556","PPP1R14C, KEPI; protein phosphatase 1 regulatory subunit 14C"]
["ENSRNOG00000032569",12,1.009623224,4,0.257321753,3.92358288,1.972171675,0.01059652,0.006634823,"up","yes","Lingo3","protein_coding","chr7:8869025-8878431:+","gi|157819613|ref|NP_001103079.1|",2400,0,"leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 precursor [Rattus norvegicus]","gi|157819612|ref|NM_001109609.1|",1913,0,"Rattus norvegicus leucine rich repeat and Ig domain containing 3 (Lingo3), mRNA","Q6GQU6",917,0,"Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.",".","GO:0005615|extracellular space;GO:0016021|integral component of membrane;GO:0031012|extracellular matrix;",".","K23533","LINGO, LRRN6; leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein"]
["ENSRNOG00000064332",12,1.009623224,4,0.257321753,3.92358288,1.972171675,0.01059652,0.006634823,"up","yes","ENSRNOG00000064332","protein_coding","chr3:158851783-158852007:+","gi|355563024|gb|EHH19586.1|",343,{"v":3e-40,"d":"3.00E-40"},"hypothetical protein EGK_02283 [Macaca mulatta]","gi|27368269|emb|AL731822.31|",213,{"v":2e-106,"d":"2.00E-106"},"Mouse DNA sequence from clone RP23-105H6 on chromosome 2, complete sequence",".",".",".",".",".",".",".",".","pfam01567","Hanta_G1","Hantavirus glycoprotein G1. The medium (M) genome segment of hantaviruses (family Bunyaviridae) encodes the two virion glycoproteins. G1 and G2, as a precursor protein in the complementary sense RNA.",".",".",".",".","."]
["ENSRNOG00000070878",12,1.009623224,4,0.257321753,3.92358288,1.972171675,0.01059652,0.006634823,"up","yes","ENSRNOG00000070878","protein_coding","chr5:110908577-110913310:-","gi|16741207|gb|AAH16446.1|",686,{"v":1e-86,"d":"1.00E-86"},"Cyp2j13 protein [Mus musculus]","gi|755507997|ref|XM_006502937.2|",335,{"v":7e-174,"d":"7.00E-174"},"PREDICTED: Mus musculus cytochrome P450, family 2, subfamily j, polypeptide 13 (Cyp2j13), transcript variant X2, mRNA","P51590",204,{"v":6e-62,"d":"6.00E-62"},"Cytochrome P450 2J3","BH0579",61.6,{"v":6E-11,"d":"6.00E-11"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.",".",".",".",".","."]
["ENSRNOG00000063647",28,2.355787522,17,1.093617449,2.154123934,1.107101256,0.01089818,0.006809103,"up","yes","ENSRNOG00000063647","protein_coding","chrX:134320773-134325672:+","gi|537128405|gb|ERE65415.1|",294,{"v":3e-30,"d":"3.00E-30"},"protein DDX26B [Cricetulus griseus]","gi|755490553|ref|XM_006544571.2|",237,{"v":2E-119,"d":"2.00E-119"},"PREDICTED: Mus musculus predicted gene 10477 (Gm10477), mRNA","Q5JSJ4",68.9,{"v":2E-12,"d":"2.00E-12"},"Integrator complex subunit 6-like",".",".",".",".","pfam15300","INT_SG_DDX_CT_C","INTS6/SAGE1/DDX26B/CT45 C-terminus. This domain is found at the C-terminus of integrator complex subunit 6 (INTS6), sarcoma antigen 1 (SAGE1), protein DDX26B (DDX26B) and members of the cancer/testis antigen family 45.",".",".",".",".","."]
["ENSRNOG00000000854",30,2.524058059,19,1.222278326,2.065043621,1.046172257,0.011845821,0.007356144,"up","yes","Ncr3","protein_coding","chr20:3638240-3643799:-","gi|260166676|ref|NP_861543.2|",917,{"v":2E-121,"d":"2.00E-121"},"natural cytotoxicity triggering receptor 3 precursor [Rattus norvegicus]","gi|30314389|gb|AY273824.1|",899,0,"Rattus norvegicus NKp30 (Nkp30) mRNA, complete cds","Q8CFD9",348,{"v":1E-119,"d":"1.00E-119"},"Natural cytotoxicity triggering receptor 3",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0002429|immune response-activating cell surface receptor signaling pathway;GO:0030101|natural killer cell activation;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0042802|identical protein binding;","K06743","NCR3, CD337; natural cytotoxicity triggering receptor 3"]
["ENSRNOG00000001757",30,2.524058059,19,1.222278326,2.065043621,1.046172257,0.011845821,0.007356144,"up","yes","Tm4sf19","protein_coding","chr11:68371647-68384591:-","gi|157786784|ref|NP_001099343.1|",791,{"v":4e-96,"d":"4.00E-96"},"transmembrane 4 L6 family member 19 [Rattus norvegicus]","gi|157786783|ref|NM_001105873.1|",766,0,"Rattus norvegicus transmembrane 4 L six family member 19 (Tm4sf19), mRNA","Q96DZ7",221,{"v":9e-65,"d":"9.00E-65"},"Transmembrane 4 L6 family member 19",".",".",".",".","pfam05805","L6_membrane","L6 membrane protein. This family consists of several eukaryotic L6 membrane proteins. L6, IL-TMP, and TM4SF5 are cell surface proteins predicted to have four transmembrane domains. Previous sequence analysis led to their assignment as members of the tetraspanin superfamily it has now been found that that they are not significantly related to genuine tetraspanins, but instead constitute their own L6 family. Several members of this family have been implicated in human cancer.",".","GO:0016021|integral component of membrane;",".","K24922","TM4SF19; transmembrane 4 L6 family member 19"]
["ENSRNOG00000070003",22,1.85097591,12,0.771965258,2.397745093,1.261678293,0.012284719,0.007589347,"up","yes","ENSRNOG00000070003","lncRNA","chr4:141519863-141571488:-",".",".",".",".","gi|672018624|ref|XR_600797.1|",926,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102547466 (LOC102547466), ncRNA",".",".",".",".",".",".",".",".","pfam12730","ABC2_membrane_4","ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family pfam01061.",".",".",".",".","."]
["ENSRNOG00000037688",23,1.935111179,13,0.836295696,2.313907852,1.210331413,0.013216136,0.008119714,"up","yes","Ak9","protein_coding","chr20:44724496-44941136:+","gi|672031948|ref|XP_008773227.1|",6208,0,"PREDICTED: adenylate kinase 9 isoform X3, partial [Rattus norvegicus]","gi|672086760|ref|XM_008773020.1|",6196,0,"PREDICTED: Rattus norvegicus similar to novel protein (RGD1560386), transcript variant X5, mRNA","Q5TCS8",1544,0,"Adenylate kinase 9","CAC3112",71.2,{"v":3e-12,"d":"3.00E-12"},"COG0563","pfam00406","ADK","Adenylate kinase.","GO:0006174|dADP phosphorylation;GO:0006186|dGDP phosphorylation;GO:0006756|AMP phosphorylation;GO:0006757|ATP generation from ADP;GO:0061508|CDP phosphorylation;GO:0061565|dAMP phosphorylation;GO:0061566|CMP phosphorylation;GO:0061567|dCMP phosphorylation;GO:0061568|GDP phosphorylation;GO:0061569|UDP phosphorylation;GO:0061570|dCDP phosphorylation;GO:0061571|TDP phosphorylation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0031965|nuclear membrane;","GO:0004017|adenylate kinase activity;GO:0004550|nucleoside diphosphate kinase activity;GO:0005524|ATP binding;GO:0050145|nucleoside monophosphate kinase activity;","K18533","AK9; adenylate/nucleoside-diphosphate kinase [EC:2.7.4.3 2.7.4.6]"]
["ENSRNOG00000020039",13,1.093758492,5,0.321652191,3.400438496,1.765720798,0.013572966,0.008315822,"up","yes","Slc5a2","protein_coding","chr1:182847106-182853306:+","gi|78486544|ref|NP_072112.2|",2989,0,"sodium/glucose cotransporter 2 [Rattus norvegicus]","gi|78486543|ref|NM_022590.2|",2248,0,"Rattus norvegicus solute carrier family 5 member 2 (Slc5a2), mRNA","P53792",1148,0,"Sodium/glucose cotransporter 2","BH2222",140,{"v":6E-34,"d":"6.00E-34"},"COG4146","pfam00474","SSF","Sodium:solute symporter family. Membership of this family is supported by a significant blast score.","GO:0000017|alpha-glucoside transport;GO:0006814|sodium ion transport;GO:0008643|carbohydrate transport;GO:0035811|negative regulation of urine volume;GO:0036359|renal potassium excretion;GO:0055085|transmembrane transport;GO:0098708|glucose import across plasma membrane;GO:0098719|sodium ion import across plasma membrane;GO:1904659|glucose transmembrane transport;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0031526|brush border membrane;","GO:0005412|glucose:sodium symporter activity;GO:0015151|alpha-glucoside transmembrane transporter activity;GO:0022857|transmembrane transporter activity;GO:0055056|D-glucose transmembrane transporter activity;","K14382","SLC5A2, SGLT2; solute carrier family 5 (sodium/glucose cotransporter), member 2"]
["ENSRNOG00000021310",13,1.093758492,5,0.321652191,3.400438496,1.765720798,0.013572966,0.008315822,"up","yes","Slc36a3","protein_coding","chr10:39243595-39270567:-","gi|67078494|ref|NP_001019935.1|",2036,0,"proton-coupled amino acid transporter 3 [Rattus norvegicus]","gi|67078493|ref|NM_001024764.1|",1725,0,"Rattus norvegicus solute carrier family 36, member 3 (Slc36a3), mRNA","Q4V8B1",788,0,"Proton-coupled amino acid transporter 3","YNL101w",87,{"v":4e-17,"d":"4.00E-17"},"COG0814","pfam01490","Aa_trans","Transmembrane amino acid transporter protein. This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.","GO:0003333|amino acid transmembrane transport;GO:0015808|L-alanine transport;GO:0015816|glycine transport;GO:0035524|proline transmembrane transport;GO:1902600|proton transmembrane transport;","GO:0016021|integral component of membrane;","GO:0005280|amino acid:proton symporter activity;GO:0015171|amino acid transmembrane transporter activity;GO:0015180|L-alanine transmembrane transporter activity;GO:0015187|glycine transmembrane transporter activity;GO:0015193|L-proline transmembrane transporter activity;","K14209","SLC36A, PAT; solute carrier family 36 (proton-coupled amino acid transporter)"]
["ENSRNOG00000042441",13,1.093758492,5,0.321652191,3.400438496,1.765720798,0.013572966,0.008315822,"up","yes","Tpd52l3","protein_coding","chr1:227773724-227784467:+","gi|157822097|ref|NP_001099819.1|",803,{"v":5e-98,"d":"5.00E-98"},"tumor protein D55 [Rattus norvegicus]","gi|672040174|ref|XM_008760353.1|",1525,0,"PREDICTED: Rattus norvegicus tumor protein D55-like (LOC103690131), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam04201","TPD52","tumor protein D52 family. The hD52 gene was originally identified through its elevated expression level in human breast carcinoma. Cloning of D52 homologues from other species has indicated that D52 may play roles in calcium-mediated signal transduction and cell proliferation. Two human homologues of hD52, hD53 and hD54, have also been identified, demonstrating the existence of a novel gene/protein family. These proteins have an amino terminal coiled-coil that allows members to form homo- and heterodimers with each other.",".","GO:0005737|cytoplasm;",".",".","."]
["ENSRNOG00000063198",13,1.093758492,5,0.321652191,3.400438496,1.765720798,0.013572966,0.008315822,"up","yes","ENSRNOG00000063198","lncRNA","chr14:76172103-76175331:+","gi|148701441|gb|EDL33388.1|",219,{"v":7e-18,"d":"7.00E-18"},"mCG1045525, partial [Mus musculus]","gi|34482112|gb|AC132346.3|",143,{"v":2E-66,"d":"2.00E-66"},"Mus musculus BAC clone RP24-179K8 from chromosome 3, complete sequence","P46935",53.1,{"v":9e-06,"d":"9.00E-06"},"E3 ubiquitin-protein ligase NEDD4",".",".",".",".","pfam12997","DUF3881","Domain of unknown function, E. rectale Gene description (DUF3881). Based on Eubacterium rectale gene EUBREC_3695. As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE14737), it appears to be upregulated in the presence of Bacteroides thetaiotaomicron vs when isolated in culture.",".",".",".",".","."]
["ENSRNOG00000000454",24,2.019246448,14,0.900626135,2.24204736,1.164816753,0.014077138,0.008596663,"up","yes","RT1-DOb","protein_coding","chr20:4619816-4625667:-","gi|57012350|ref|NP_001008846.1|",807,{"v":5e-97,"d":"5.00E-97"},"RT1 class II, DO beta [Rattus norvegicus]","gi|89214481|gb|AC120734.5|",2190,0,"Rattus norvegicus BAC CH230-220D1 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","P13765",229,{"v":1e-66,"d":"1.00E-66"},"HLA class II histocompatibility antigen, DO beta chain",".",".",".",".","pfam00969","MHC_II_beta","Class II histocompatibility antigen, beta domain.","GO:0002250|adaptive immune response;GO:0002381|immunoglobulin production involved in immunoglobulin mediated immune response;GO:0002503|peptide antigen assembly with MHC class II protein complex;GO:0002587|negative regulation of antigen processing and presentation of peptide antigen via MHC class II;GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0050870|positive regulation of T cell activation;","GO:0005764|lysosome;GO:0016021|integral component of membrane;GO:0042613|MHC class II protein complex;","GO:0023026|MHC class II protein complex binding;","K06752","MHC2; MHC class II antigen"]
["ENSRNOG00000016571",24,2.019246448,14,0.900626135,2.24204736,1.164816753,0.014077138,0.008596663,"up","yes","Ngf","protein_coding","chr2:189901058-189954452:+","gi|537265807|gb|ERE90958.1|",1489,0,"beta-nerve growth factor-like protein [Cricetulus griseus]","gi|456367245|ref|NM_001277055.1|",862,0,"Rattus norvegicus nerve growth factor (beta polypeptide) (Ngf), mRNA","P25427",499,{"v":2E-175,"d":"2.00E-175"},"Beta-nerve growth factor",".",".",".",".","pfam00243","NGF","Nerve growth factor family.","GO:0001934|positive regulation of protein phosphorylation;GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006954|inflammatory response;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007171|activation of transmembrane receptor protein tyrosine kinase activity;GO:0007422|peripheral nervous system development;GO:0007568|aging;GO:0007613|memory;GO:0007623|circadian rhythm;GO:0008284|positive regulation of cell proliferation;GO:0008344|adult locomotory behavior;GO:0008625|extrinsic apoptotic signaling pathway via death domain receptors;GO:0009314|response to radiation;GO:0009410|response to xenobiotic stimulus;GO:0009612|response to mechanical stimulus;GO:0010033|response to organic substance;GO:0010193|response to ozone;GO:0010628|positive regulation of gene expression;GO:0010951|negative regulation of endopeptidase activity;GO:0010976|positive regulation of neuron projection development;GO:0014042|positive regulation of neuron maturation;GO:0014070|response to organic cyclic compound;GO:0019233|sensory perception of pain;GO:0021675|nerve development;GO:0030307|positive regulation of cell growth;GO:0031175|neuron projection development;GO:0031398|positive regulation of protein ubiquitination;GO:0031954|positive regulation of protein autophosphorylation;GO:0032092|positive regulation of protein binding;GO:0032496|response to lipopolysaccharide;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0035094|response to nicotine;GO:0038180|nerve growth factor signaling pathway;GO:0043388|positive regulation of DNA binding;GO:0043434|response to peptide hormone;GO:0043524|negative regulation of neuron apoptotic process;GO:0045664|regulation of neuron differentiation;GO:0045666|positive regulation of neuron differentiation;GO:0045773|positive regulation of axon extension;GO:0046579|positive regulation of Ras protein signal transduction;GO:0046928|regulation of neurotransmitter secretion;GO:0048666|neuron development;GO:0048672|positive regulation of collateral sprouting;GO:0048812|neuron projection morphogenesis;GO:0050804|modulation of chemical synaptic transmission;GO:0051091|positive regulation of DNA-binding transcription factor activity;GO:0051279|regulation of release of sequestered calcium ion into cytosol;GO:0051384|response to glucocorticoid;GO:0051388|positive regulation of neurotrophin TRK receptor signaling pathway;GO:0051402|neuron apoptotic process;GO:0051602|response to electrical stimulus;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0097192|extrinsic apoptotic signaling pathway in absence of ligand;GO:1902236|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:2000648|positive regulation of stem cell proliferation;GO:2000675|negative regulation of type B pancreatic cell apoptotic process;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005788|endoplasmic reticulum lumen;GO:0005796|Golgi lumen;GO:0008021|synaptic vesicle;GO:0030424|axon;GO:0030425|dendrite;GO:0031904|endosome lumen;GO:0044306|neuron projection terminus;","GO:0003674|molecular_function;GO:0005163|nerve growth factor receptor binding;GO:0008083|growth factor activity;GO:0008191|metalloendopeptidase inhibitor activity;GO:0008289|lipid binding;GO:0008656|cysteine-type endopeptidase activator activity involved in apoptotic process;GO:0030297|transmembrane receptor protein tyrosine kinase activator activity;GO:0038177|death receptor agonist activity;","K02582","NGFB; nerve growth factor, beta"]
["ENSRNOG00000027466",24,2.019246448,14,0.900626135,2.24204736,1.164816753,0.014077138,0.008596663,"up","yes","Cd27","protein_coding","chr4:158030703-158035592:-","gi|557948013|ref|NP_001273682.1|",806,{"v":1e-102,"d":"1.00E-102"},"CD27 antigen isoform c precursor [Mus musculus]","gi|66730456|ref|NM_001024335.1|",1061,0,"Rattus norvegicus CD27 molecule (Cd27), mRNA","P41272",270,{"v":1e-85,"d":"1.00E-85"},"CD27 antigen",".",".",".",".","pfam00020","TNFR_c6","TNFR/NGFR cysteine-rich region.","GO:0043066|negative regulation of apoptotic process;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045471|response to ethanol;GO:0045579|positive regulation of B cell differentiation;GO:0045582|positive regulation of T cell differentiation;GO:0046330|positive regulation of JNK cascade;GO:0070233|negative regulation of T cell apoptotic process;GO:0097191|extrinsic apoptotic signaling pathway;","GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0003674|molecular_function;GO:0004888|transmembrane signaling receptor activity;GO:0043027|cysteine-type endopeptidase inhibitor activity involved in apoptotic process;","K05144","TNFRSF7, CD27; tumor necrosis factor receptor superfamily member 7"]
["ENSRNOG00000008622",18,1.514434836,9,0.578973944,2.61572192,1.387209175,0.01482686,0.009003008,"up","yes","Creb5","protein_coding","chr4:82393730-82790325:+","gi|197386711|ref|NP_001128093.1|",2184,0,"cyclic AMP-responsive element-binding protein 5 [Rattus norvegicus]","gi|197386710|ref|NM_001134621.1|",4148,0,"Rattus norvegicus cAMP responsive element binding protein 5 (Creb5), mRNA","Q02930",715,0,"Cyclic AMP-responsive element-binding protein 5",".",".",".",".","pfam00170","bZIP_1","bZIP transcription factor. The Pfam entry includes the basic region and the leucine zipper region.","GO:0006357|regulation of transcription by RNA polymerase II;GO:0045444|fat cell differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0050872|white fat cell differentiation;GO:0060612|adipose tissue development;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0035497|cAMP response element binding;GO:0042802|identical protein binding;GO:1990837|sequence-specific double-stranded DNA binding;","K09047","CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5"]
["ENSRNOG00000020451",18,1.514434836,9,0.578973944,2.61572192,1.387209175,0.01482686,0.009003008,"up","yes","Cd81","protein_coding","chr1:198241484-198251660:+","gi|815890893|ref|NP_037219.2|",1025,{"v":2e-130,"d":"2.00E-130"},"CD81 antigen [Rattus norvegicus]","gi|815890892|ref|NM_013087.2|",841,0,"Rattus norvegicus Cd81 molecule (Cd81), mRNA","Q62745",399,{"v":1e-131,"d":"1.00E-131"},"CD81 antigen",".",".",".",".","pfam00335","Tetraspannin","Tetraspanin family.","GO:0001771|immunological synapse formation;GO:0002455|humoral immune response mediated by circulating immunoglobulin;GO:0002863|positive regulation of inflammatory response to antigenic stimulus;GO:0008104|protein localization;GO:0008284|positive regulation of cell proliferation;GO:0009611|response to wounding;GO:0014905|myoblast fusion involved in skeletal muscle regeneration;GO:0030890|positive regulation of B cell proliferation;GO:0031623|receptor internalization;GO:0031647|regulation of protein stability;GO:0034238|macrophage fusion;GO:0035783|CD4-positive, alpha-beta T cell costimulation;GO:0040008|regulation of growth;GO:0042127|regulation of cell proliferation;GO:0043128|positive regulation of 1-phosphatidylinositol 4-kinase activity;GO:0043410|positive regulation of MAPK cascade;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0046718|viral entry into host cell;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0050861|positive regulation of B cell receptor signaling pathway;GO:0050862|positive regulation of T cell receptor signaling pathway;GO:0050871|positive regulation of B cell activation;GO:0061462|protein localization to lysosome;GO:0070863|positive regulation of protein exit from endoplasmic reticulum;GO:0071404|cellular response to low-density lipoprotein particle stimulus;GO:0072659|protein localization to plasma membrane;GO:0072675|osteoclast fusion;GO:1903911|positive regulation of receptor clustering;GO:1904352|positive regulation of protein catabolic process in the vacuole;GO:1905521|regulation of macrophage migration;GO:1905676|positive regulation of adaptive immune memory response;GO:2000145|regulation of cell motility;GO:2000553|positive regulation of T-helper 2 cell cytokine production;GO:2000563|positive regulation of CD4-positive, alpha-beta T cell proliferation;GO:2001190|positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;","GO:0001772|immunological synapse;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009925|basal plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;GO:0031982|vesicle;GO:0070062|extracellular exosome;GO:0097197|tetraspanin-enriched microdomain;","GO:0001618|virus receptor activity;GO:0005178|integrin binding;GO:0005515|protein binding;GO:0015485|cholesterol binding;GO:0042289|MHC class II protein binding;GO:1990459|transferrin receptor binding;","K06508","CD81, TAPA1, TSPAN28; CD81 antigen"]
["ENSRNOG00000023935",18,1.514434836,9,0.578973944,2.61572192,1.387209175,0.01482686,0.009003008,"up","yes","Nrsn2","protein_coding","chr3:140838814-140847297:-","gi|148674017|gb|EDL05964.1|",1103,{"v":1E-146,"d":"1.00E-146"},"neurensin 2, partial [Mus musculus]","gi|157818262|ref|NM_001109561.1|",1401,0,"Rattus norvegicus neurensin 2 (Nrsn2), mRNA","Q5HZK2",392,{"v":7e-134,"d":"7.00E-134"},"Neurensin-2",".",".",".",".","pfam14927","Neurensin","Neurensin. The neurensin family includes the neuronal membrane proteins neurensin-1 and neurensin-2. Neurensin-1 plays a role in neurite extension.","GO:0007399|nervous system development;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030133|transport vesicle;GO:0031410|cytoplasmic vesicle;GO:0043005|neuron projection;GO:0043025|neuronal cell body;",".",".","."]
["ENSRNOG00000031439",18,1.514434836,9,0.578973944,2.61572192,1.387209175,0.01482686,0.009003008,"up","yes","AC117869.1","protein_coding","chr19:40013001-40013775:+","gi|402905506|ref|XP_003915560.1|",726,{"v":5e-96,"d":"5.00E-96"},"PREDICTED: 40S ribosomal protein S16 [Papio anubis]","gi|310703681|ref|NM_001169146.1|",396,0,"Rattus norvegicus ribosomal protein S16 (Rps16), mRNA","P62250",283,{"v":3e-97,"d":"3.00E-97"},"40S ribosomal protein S16","SPBC18H10.14",202,{"v":4e-66,"d":"4.00E-66"},"COG0103","pfam00380","Ribosomal_S9","Ribosomal protein S9/S16. This family includes small ribosomal subunit S9 from prokaryotes and S16 from eukaryotes.",".",".",".",".","."]
["ENSRNOG00000062881",18,1.514434836,9,0.578973944,2.61572192,1.387209175,0.01482686,0.009003008,"up","yes","ENSRNOG00000062881","protein_coding","chr11:55680830-55684302:-","gi|56590|emb|CAA37647.1|",620,{"v":2e-69,"d":"2.00E-69"},"ORF4 [Rattus norvegicus]","gi|32362323|gb|AC116071.5|",875,0,"Rattus norvegicus 3 BAC CH230-230O7 (Children's Hospital Oakland Research Institute) complete sequence","P11369",233,{"v":3e-61,"d":"3.00E-61"},"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam08333","DUF1725","Protein of unknown function (DUF1725). This family include many eukaryotic and one bacterial sequence. Many of its members are annotated as being putative L1 retrotransposons or LINE-1 reverse transcriptase homologs. The region in question is found repeated in some family members.",".",".",".",".","."]
["ENSRNOG00000030253",25,2.103381716,15,0.964956573,2.179768267,1.124174769,0.014868063,0.009025007,"up","yes","Tafa3","protein_coding","chr2:192267093-192274019:-","gi|564300804|ref|XP_006224296.1|",679,{"v":1e-81,"d":"1.00E-81"},"PREDICTED: protein FAM19A3 [Rattus norvegicus]","gi|672016182|ref|XM_006224235.2|",2176,0,"PREDICTED: Rattus norvegicus family with sequence similarity 19 (chemokine (C-C motif)-like), member A3 (Fam19a3), transcript variant X2, mRNA","Q7TPG6",246,{"v":8e-76,"d":"8.00E-76"},"Protein FAM19A3",".",".",".",".","pfam12020","TAFA","TAFA family. This family of secreted proteins are brain specific and thought to be chemokines. These proteins are found in vertebrates. Proteins in this family are typically between 94 to 133 amino acids in length and contain a number of conserved cysteines.","GO:0007165|signal transduction;GO:0014016|neuroblast differentiation;GO:1902692|regulation of neuroblast proliferation;GO:1903979|negative regulation of microglial cell activation;GO:1903980|positive regulation of microglial cell activation;","GO:0005615|extracellular space;","GO:0048018|receptor ligand activity;","K25542","TAFA2_3, FAM19A2_3; chemokine-like protein TAFA2/3"]
["ENSRNOG00000065800",27,2.271652253,17,1.093617449,2.077190937,1.054633836,0.016246101,0.009807908,"up","yes","ENSRNOG00000065800","lncRNA","chr3:77059439-77068233:+",".",".",".",".","gi|672046250|ref|XR_591577.1|",1201,0,"PREDICTED: Rattus norvegicus uncharacterized LOC103691845 (LOC103691845), ncRNA",".",".",".",".",".",".",".",".","pfam14024","DUF4240","Protein of unknown function (DUF4240). This presumed domain is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 169 and 263 amino acids in length. This domain is often associated with the WGR domain pfam05406.",".",".",".",".","."]
["ENSRNOG00000033706",19,1.598570104,10,0.643304382,2.484935824,1.313208593,0.016377509,0.009876289,"up","yes","Klk14","protein_coding","chr1:94131998-94137240:+","gi|293344027|ref|XP_001080394.2|",1231,{"v":7e-167,"d":"7.00E-167"},"PREDICTED: kallikrein-14 [Rattus norvegicus]","gi|672013508|ref|XM_001080394.5|",1202,0,"PREDICTED: Rattus norvegicus kallikrein related-peptidase 14 (Klk14), mRNA","Q8CGR5",442,{"v":5e-154,"d":"5.00E-154"},"Kallikrein-14","VC1200",103,{"v":1e-23,"d":"1.00E-23"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;GO:0009566|fertilization;GO:0045744|negative regulation of G protein-coupled receptor signaling pathway;GO:0045745|positive regulation of G protein-coupled receptor signaling pathway;GO:0048730|epidermis morphogenesis;GO:0070684|seminal clot liquefaction;","GO:0005615|extracellular space;GO:0030141|secretory granule;","GO:0004252|serine-type endopeptidase activity;","K09622","KLK14; kallikrein 14 [EC:3.4.21.-]"]
["ENSRNOG00000063720",19,1.598570104,10,0.643304382,2.484935824,1.313208593,0.016377509,0.009876289,"up","yes","ENSRNOG00000063720","lncRNA","chr6:44003036-44007070:-",".",".",".",".","gi|880946383|ref|XM_013121973.1|",2344,0,"PREDICTED: Mesocricetus auratus SRY (sex determining region Y)-box 11 (Sox11), mRNA",".",".",".",".",".",".",".",".","pfam10325","7TM_GPCR_Srz","Serpentine type 7TM GPCR chemoreceptor Srz. Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srz is a solo families amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srz appear to be under strong adaptive evolutionary pressure.",".",".",".",".","."]
["ENSRNOG00000066084",19,1.598570104,10,0.643304382,2.484935824,1.313208593,0.016377509,0.009876289,"up","yes","ENSRNOG00000066084","lncRNA","chr16:18736796-18738150:-",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","pfam11748","DUF3306","Protein of unknown function (DUF3306). This family of proteobacterial species proteins has no known function.",".",".",".",".","."]
["ENSRNOG00000068358",19,1.598570104,10,0.643304382,2.484935824,1.313208593,0.016377509,0.009876289,"up","yes","ENSRNOG00000068358","lncRNA","chr3:141305288-141316886:+","gi|12851702|dbj|BAB29137.1|",141,{"v":1e-07,"d":"1.00E-07"},"unnamed protein product [Mus musculus]","gi|86439996|gb|AC129342.5|",790,0,"Rattus norvegicus BAC CH230-229B21 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam04403","PqiA","Paraquat-inducible protein A. Paraquat is a superoxide radical-generating agent. The promoter for the pqiA gene is also inducible by other known superoxide generators. This is predicted to be a family of integral membrane proteins, possibly located in the inner membrane. This family is related to NADH dehydrogenase subunit 2 (pfam00361).",".",".",".",".","."]
["ENSRNOG00000029859",14,1.177893761,6,0.385982629,3.051675574,1.609601596,0.01643545,0.00990136,"up","yes","AABR07021384.1","protein_coding","chr13:63894996-63895466:-","gi|355750095|gb|EHH54433.1|",630,{"v":4e-81,"d":"4.00E-81"},"hypothetical protein EGM_15272 [Macaca fascicularis]","gi|298916685|emb|FQ210401.1|",432,0,"Rattus norvegicus TL0ABA29YG01 mRNA sequence","P62752",244,{"v":2e-81,"d":"2.00E-81"},"60S ribosomal protein L23a","YOL127w",162,{"v":3e-50,"d":"3.00E-50"},"COG0089","pfam03939","Ribosomal_L23eN","Ribosomal protein L23, N-terminal domain. The N-terminal domain appears to be specific to the eukaryotic ribosomal proteins L25, L23, and L23a.","GO:0006412|translation;",".",".",".","."]
["ENSRNOG00000049689",14,1.177893761,6,0.385982629,3.051675574,1.609601596,0.01643545,0.00990136,"up","yes","Smim18","protein_coding","chr16:58431742-58439651:+","gi|829862817|ref|XP_012639591.1|",537,{"v":1e-63,"d":"1.00E-63"},"PREDICTED: small integral membrane protein 18 isoform X1 [Microcebus murinus]","gi|672029453|ref|XM_006222253.2|",597,0,"PREDICTED: Rattus norvegicus uncharacterized LOC100909793 (LOC100909793), transcript variant X2, mRNA","P0DKX4",195,{"v":7e-60,"d":"7.00E-60"},"Small integral membrane protein 18",".",".",".",".","pfam13042","DUF3902","Protein of unknown function (DUF3902). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 170 amino acids in length. There is a conserved LGI sequence motif.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000053430",14,1.177893761,6,0.385982629,3.051675574,1.609601596,0.01643545,0.00990136,"up","yes","Slco4a1","protein_coding","chr3:167559316-167578305:+","gi|67514562|ref|NP_598292.2|",3194,0,"solute carrier organic anion transporter family member 4A1 [Rattus norvegicus]","gi|67514561|ref|NM_133608.2|",2964,0,"Rattus norvegicus solute carrier organic anion transporter family, member 4a1 (Slco4a1), mRNA","Q99N01",1229,0,"Solute carrier organic anion transporter family member 4A1",".",".",".",".","pfam03137","OATP","Organic Anion Transporter Polypeptide (OATP) family. This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.","GO:0006811|ion transport;GO:0042403|thyroid hormone metabolic process;GO:0043252|sodium-independent organic anion transport;GO:0055085|transmembrane transport;GO:0070327|thyroid hormone transport;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016021|integral component of membrane;","GO:0015347|sodium-independent organic anion transmembrane transporter activity;GO:0015349|thyroid hormone transmembrane transporter activity;GO:0022857|transmembrane transporter activity;","K14354","SLCO4A; solute carrier organic anion transporter family, member 4A"]
["ENSRNOG00000055858",14,1.177893761,6,0.385982629,3.051675574,1.609601596,0.01643545,0.00990136,"up","yes","Myb","protein_coding","chr1:15939761-15973057:-","gi|564296048|ref|XP_006222900.1|",3674,0,"PREDICTED: transcriptional activator Myb isoform X1 [Rattus norvegicus]","gi|672012493|ref|XM_006222838.2|",5802,0,"PREDICTED: Rattus norvegicus similar to Myb proto-oncogene protein (C-myb) (predicted) (RGD1560020_predicted), transcript variant X1, mRNA","P06876",733,0,"Transcriptional activator Myb","ECU11g1690",154,{"v":2e-40,"d":"2.00E-40"},"COG5147","pfam09316","Cmyb_C","C-myb, C-terminal. Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumorigenesis.","GO:0000082|G1/S transition of mitotic cell cycle;GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001666|response to hypoxia;GO:0001701|in utero embryonic development;GO:0006338|chromatin remodeling;GO:0006355|regulation of transcription, DNA-templated;GO:0006816|calcium ion transport;GO:0010468|regulation of gene expression;GO:0017145|stem cell division;GO:0030099|myeloid cell differentiation;GO:0030183|B cell differentiation;GO:0032967|positive regulation of collagen biosynthetic process;GO:0043525|positive regulation of neuron apoptotic process;GO:0045624|positive regulation of T-helper cell differentiation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048536|spleen development;GO:0048538|thymus development;GO:0048566|embryonic digestive tract development;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0048872|homeostasis of number of cells;GO:0051571|positive regulation of histone H3-K4 methylation;GO:0051574|positive regulation of histone H3-K9 methylation;GO:0060252|positive regulation of glial cell proliferation;GO:0070301|cellular response to hydrogen peroxide;GO:0071300|cellular response to retinoic acid;GO:0071354|cellular response to interleukin-6;GO:0071636|positive regulation of transforming growth factor beta production;GO:1901216|positive regulation of neuron death;GO:1901533|negative regulation of hematopoietic progenitor cell differentiation;GO:1904899|positive regulation of hepatic stellate cell proliferation;GO:1990830|cellular response to leukemia inhibitory factor;GO:2000491|positive regulation of hepatic stellate cell activation;GO:2000845|positive regulation of testosterone secretion;","GO:0005575|cellular_component;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005829|cytosol;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:0003677|DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0071987|WD40-repeat domain binding;","K09420","MYB, C-MYB; transcriptional activator Myb"]
["ENSRNOG00000061863",14,1.177893761,6,0.385982629,3.051675574,1.609601596,0.01643545,0.00990136,"up","yes","H1f6","protein_coding","chr17:41427323-41428119:-","gi|6981006|ref|NP_036711.1|",670,{"v":1E-84,"d":"1.00E-84"},"histone H1t [Rattus norvegicus]","gi|204596|gb|M13170.1|RATHIS1TP",797,0,"Rat testis-specific H1 histone variant H1t gene, complete cds","P06349",262,{"v":4e-86,"d":"4.00E-86"},"Histone H1t",".",".",".",".","pfam00538","Linker_histone","linker histone H1 and H5 family. Linker histone H1 is an essential component of chromatin structure. H1 links nucleosomes into higher order structures Histone H1 is replaced by histone H5 in some cell types.","GO:0006334|nucleosome assembly;GO:0007283|spermatogenesis;GO:0007339|binding of sperm to zona pellucida;GO:0016584|nucleosome positioning;GO:0030154|cell differentiation;GO:0030261|chromosome condensation;GO:0030317|flagellated sperm motility;GO:0045910|negative regulation of DNA recombination;","GO:0000786|nucleosome;GO:0000794|condensed nuclear chromosome;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0003690|double-stranded DNA binding;GO:0031492|nucleosomal DNA binding;","K11275","H1_5; histone H1/5"]
["ENSRNOG00000071200",14,1.177893761,6,0.385982629,3.051675574,1.609601596,0.01643545,0.00990136,"up","yes","RGD1559714","protein_coding","chr2:181837105-181953508:-","gi|392350953|ref|XP_003750803.1|",1874,0,"PREDICTED: TD and POZ domain-containing protein 5-like isoform X2 [Rattus norvegicus]","gi|199612194|gb|FJ004892.1|",2152,0,"Rattus norvegicus clone T1E16-A RTDPOZ-T1 mRNA, complete cds","Q717B2",472,{"v":2e-157,"d":"2.00E-157"},"TD and POZ domain-containing protein 2",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.",".",".",".",".","."]
["ENSRNOG00000017528",20,1.682705373,11,0.70763482,2.377929018,1.249705651,0.017807735,0.010637452,"up","yes","Gpr157","protein_coding","chr5:160550713-160566432:+","gi|58865784|ref|NP_001012107.1|",1364,{"v":5e-180,"d":"5.00E-180"},"probable G-protein coupled receptor 157 [Rattus norvegicus]","gi|58865783|ref|NM_001012107.1|",2337,0,"Rattus norvegicus G protein-coupled receptor 157 (Gpr157), mRNA","Q5FVG1",530,0,"G-protein coupled receptor 157",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0007166|cell surface receptor signaling pathway;GO:0007186|G protein-coupled receptor signaling pathway;GO:0048512|circadian behavior;GO:0051482|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway;GO:0060019|radial glial cell differentiation;","GO:0016021|integral component of membrane;GO:0060170|ciliary membrane;","GO:0004930|G protein-coupled receptor activity;","K08467","GPR157; G protein-coupled receptor 157"]
["ENSRNOG00000006527",8,0.673082149,2,0.128660876,5.23144384,2.387209175,0.018742709,0.011125168,"up","yes","Slc6a1","protein_coding","chr4:147466965-147482293:+","gi|537137169|gb|ERE66927.1|",3160,0,"sodium- and chloride-dependent GABA transporter 1-like protein [Cricetulus griseus]","gi|564348261|ref|XM_006237059.1|",4045,0,"PREDICTED: Rattus norvegicus solute carrier family 6 (neurotransmitter transporter), member 1 (Slc6a1), transcript variant X1, mRNA","P23978",1192,0,"Sodium- and chloride-dependent GABA transporter 1","AF1995",212,{"v":7e-58,"d":"7.00E-58"},"COG0733","pfam00209","SNF","Sodium:neurotransmitter symporter family.","GO:0007612|learning;GO:0007613|memory;GO:0008306|associative learning;GO:0009636|response to toxic substance;GO:0009744|response to sucrose;GO:0010033|response to organic substance;GO:0010035|response to inorganic substance;GO:0010243|response to organonitrogen compound;GO:0010288|response to lead ion;GO:0014054|positive regulation of gamma-aminobutyric acid secretion;GO:0014070|response to organic cyclic compound;GO:0014074|response to purine-containing compound;GO:0032229|negative regulation of synaptic transmission, GABAergic;GO:0032355|response to estradiol;GO:0035725|sodium ion transmembrane transport;GO:0042220|response to cocaine;GO:0050808|synapse organization;GO:0051592|response to calcium ion;GO:0051939|gamma-aminobutyric acid import;GO:0098658|inorganic anion import across plasma membrane;GO:0098719|sodium ion import across plasma membrane;GO:0098810|neurotransmitter reuptake;GO:1902476|chloride transmembrane transport;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0009986|cell surface;GO:0030424|axon;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0098982|GABA-ergic synapse;GO:0099055|integral component of postsynaptic membrane;GO:0099056|integral component of presynaptic membrane;","GO:0005332|gamma-aminobutyric acid:sodium symporter activity;GO:0005515|protein binding;GO:0015185|gamma-aminobutyric acid transmembrane transporter activity;GO:0015378|sodium:chloride symporter activity;GO:0042802|identical protein binding;GO:0046872|metal ion binding;","K05034","SLC6A1, GAT1; solute carrier family 6 (neurotransmitter transporter, GABA) member 1"]
["ENSRNOG00000018701",8,0.673082149,2,0.128660876,5.23144384,2.387209175,0.018742709,0.011125168,"up","yes","Tpsg1","protein_coding","chr10:14386352-14390258:+","gi|28212252|ref|NP_783183.1|",1373,0,"tryptase gamma precursor [Rattus norvegicus]","gi|31342208|ref|NM_175593.2|",1065,0,"Rattus norvegicus tryptase gamma 1 (Tpsg1), mRNA","Q9QUL7",473,{"v":7e-166,"d":"7.00E-166"},"Tryptase gamma","VC1649",108,{"v":7e-25,"d":"7.00E-25"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;","GO:0005615|extracellular space;GO:0016021|integral component of membrane;","GO:0004252|serine-type endopeptidase activity;","K09615","TPSG1; tryptase gamma 1 [EC:3.4.21.-]"]
["ENSRNOG00000027971",8,0.673082149,2,0.128660876,5.23144384,2.387209175,0.018742709,0.011125168,"up","yes","Lrrc31","protein_coding","chr2:112700136-112724322:+","gi|564336138|ref|XP_006232302.1|",2204,0,"PREDICTED: leucine-rich repeat-containing protein 31 isoform X4 [Rattus norvegicus]","gi|672042193|ref|XM_008760950.1|",2650,0,"PREDICTED: Rattus norvegicus leucine rich repeat containing 31 (Lrrc31), transcript variant X6, mRNA",".",".",".",".",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.",".",".",".",".","."]
["ENSRNOG00000064153",8,0.673082149,2,0.128660876,5.23144384,2.387209175,0.018742709,0.011125168,"up","yes","ENSRNOG00000064153","lncRNA","chr5:56486736-56520627:-","gi|672019223|ref|XP_008774152.1|",247,{"v":3E-24,"d":"3.00E-24"},"PREDICTED: 60S ribosomal protein L39-like [Rattus norvegicus]","gi|672019222|ref|XM_008775930.1|",336,{"v":2E-174,"d":"2.00E-174"},"PREDICTED: Rattus norvegicus 60S ribosomal protein L39-like (LOC103692335), mRNA","Q90YS9",56.6,{"v":5e-10,"d":"5.00E-10"},"60S ribosomal protein L39",".",".",".",".","pfam00832","Ribosomal_L39","Ribosomal L39 protein.",".",".",".",".","."]
["ENSRNOG00000065390",8,0.673082149,2,0.128660876,5.23144384,2.387209175,0.018742709,0.011125168,"up","yes","Olr1387","protein_coding","chr10:33596756-33601318:+","gi|47576123|ref|NP_001000001.1|",1387,{"v":1E-176,"d":"1.00E-176"},"olfactory receptor Olr1387 [Rattus norvegicus]","gi|20068543|emb|AL606829.13|",1683,0,"Mouse DNA sequence from clone RP23-10M12 on chromosome 11, complete sequence","Q60883",497,{"v":2e-162,"d":"2.00E-162"},"Olfactory receptor 10",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.",".",".",".",".","."]
["ENSRNOG00000067200",8,0.673082149,2,0.128660876,5.23144384,2.387209175,0.018742709,0.011125168,"up","yes","ENSRNOG00000067200","lncRNA","chr2:76323450-76328412:-",".",".",".",".","gi|46309642|gb|AC134786.6|",369,0,"Mus musculus chromosome 15, clone RP24-502A14, complete sequence",".",".",".",".",".",".",".",".","pfam08594","UPF0300","Uncharacterized protein family (UPF0300). This family of proteins appear to be specific to S. pombe.",".",".",".",".","."]
["ENSRNOG00000067411",8,0.673082149,2,0.128660876,5.23144384,2.387209175,0.018742709,0.011125168,"up","yes","ENSRNOG00000067411","lncRNA","chr7:16492567-16512328:+",".",".",".",".","gi|341573159|gb|AC240650.5|",152,{"v":6e-72,"d":"6.00E-72"},"Rattus norvegicus Y Chr BAC RNECO-144C03 (Amplicon Express Rat SHR-Akr (EcoR1 Digest) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam03544","TonB_C","Gram-negative bacterial TonB protein C-terminal. The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.",".",".",".",".","."]
["ENSRNOG00000068045",8,0.673082149,2,0.128660876,5.23144384,2.387209175,0.018742709,0.011125168,"up","yes","Dmrta2","protein_coding","chr5:124805883-124811630:+","gi|532020056|ref|XP_005353638.1|",1336,{"v":4e-170,"d":"4.00E-170"},"PREDICTED: doublesex- and mab-3-related transcription factor A2 isoform X1 [Microtus ochrogaster]","gi|564352179|ref|XM_006238589.1|",2945,0,"PREDICTED: Rattus norvegicus DMRT-like family A2 (Dmrta2), transcript variant X1, mRNA","A6QQ94",515,{"v":3e-170,"d":"3.00E-170"},"Doublesex- and mab-3-related transcription factor A2",".",".",".",".","pfam00751","DM","DM DNA binding domain. The DM domain is named after dsx and mab-3. dsx contains a single amino-terminal DM domain, whereas mab-3 contains two amino-terminal domains. The DM domain has a pattern of conserved zinc chelating residues C2H2C4. The dsx DM domain has been shown to dimerise and bind palindromic DNA.",".",".",".",".","."]
["ENSRNOG00000069611",8,0.673082149,2,0.128660876,5.23144384,2.387209175,0.018742709,0.011125168,"up","yes","ENSRNOG00000069611","lncRNA","chr3:15802470-15822182:-",".",".",".",".","gi|26984852|emb|AL928710.6|",437,0,"Mouse DNA sequence from clone RP23-255P20 on chromosome 2, complete sequence",".",".",".",".",".",".",".",".","pfam12968","DUF3856","Domain of Unknown Function (DUF3856). TPR-like protein. The 2hr2 structure belongs to the SCOP all alpha class, TPR-like superfamily, CT2138-like family. A DALI search gives hits with the putative peptidyl-prolyl isomerase 2fbn (Z=16), the SGTA protein (Z=16), the PLCR protein 2qfc (Z=16), a putative FK506-binding protein (PDB:1qz2-A; DALI Z-score 15.3; RMSD 2.9; 16% sequence identity within 132 superimposed residues), and with the tetratricopeptide repeats of the protein phosphatase 5 (PDB:2bug; DALI Z-score 15.1; RMSD 2.5; 19% sequence identity within 117 superimposed residues).",".",".",".",".","."]
["ENSRNOG00000020021",21,1.766840642,12,0.771965258,2.28875668,1.194564097,0.019116261,0.011320556,"up","yes","Brsk2","protein_coding","chr1:197035633-197088092:+","gi|347602471|sp|D3ZML2.1|BRSK2_RAT",3543,0,"RecName: Full=Serine/threonine-protein kinase BRSK2; AltName: Full=Brain-specific serine/threonine-protein kinase 2; Short=BR serine/threonine-protein kinase 2; AltName: Full=Serine/threonine-protein kinase SAD-A","gi|454523098|ref|NM_001276763.1|",1719,0,"Mus musculus BR serine/threonine kinase 2 (Brsk2), transcript variant 4, mRNA","D3ZML2",1369,0,"Serine/threonine-protein kinase BRSK2",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.",".",".",".",".","."]
["ENSRNOG00000023858",21,1.766840642,12,0.771965258,2.28875668,1.194564097,0.019116261,0.011320556,"up","yes","Prss39","protein_coding","chr9:36707328-36713001:+","gi|61557348|ref|NP_001013244.1|",1784,0,"serine protease 40 precursor [Rattus norvegicus]","gi|61557347|ref|NM_001013226.1|",1565,0,"Rattus norvegicus protease, serine, 39 (Prss39), mRNA","Q6AXZ6",691,0,"Serine protease 40","mlr3307",88.6,{"v":2e-18,"d":"2.00E-18"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;","GO:0001669|acrosomal vesicle;","GO:0004252|serine-type endopeptidase activity;",".","."]
["ENSRNOG00000063150",21,1.766840642,12,0.771965258,2.28875668,1.194564097,0.019116261,0.011320556,"up","yes","Rab42","protein_coding","chr5:144496215-144498848:-","gi|126116579|ref|NP_001075120.1|",1069,{"v":4e-138,"d":"4.00E-138"},"putative Ras-related protein Rab-42 [Mus musculus]","gi|672054317|ref|XM_008764194.1|",1417,0,"PREDICTED: Rattus norvegicus similar to RAB family member (rab-39) (LOC682865), mRNA","Q0PD08",416,{"v":1E-139,"d":"1.00E-139"},"Ras-related protein Rab-42","SPAC18G6.03",143,{"v":1e-37,"d":"1.00E-37"},"COG1100","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.",".",".",".",".","."]
["ENSRNOG00000010094",11,0.925487955,4,0.257321753,3.59661764,1.846640793,0.019203255,0.011357676,"up","yes","Kcnmb2","protein_coding","chr2:114935976-114975173:+","gi|149048639|gb|EDM01180.1|",1391,0,"potassium large conductance calcium-activated channel, subfamily M, beta member 2, isoform CRA_c [Rattus norvegicus]","gi|755502815|ref|XM_006535549.2|",1563,0,"PREDICTED: Mus musculus potassium large conductance calcium-activated channel, subfamily M, beta member 2 (Kcnmb2), transcript variant X2, mRNA","Q9CZM9",490,{"v":4e-169,"d":"4.00E-169"},"Calcium-activated potassium channel subunit beta-2",".",".",".",".","pfam03185","CaKB","Calcium-activated potassium channel, beta subunit.","GO:0001508|action potential;GO:0005513|detection of calcium ion;GO:0006813|potassium ion transport;GO:0019228|neuronal action potential;GO:0071805|potassium ion transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0008076|voltage-gated potassium channel complex;GO:0016021|integral component of membrane;","GO:0005267|potassium channel activity;GO:0015269|calcium-activated potassium channel activity;GO:0015459|potassium channel regulator activity;","K04938","KCNMB2; potassium large conductance calcium-activated channel subfamily M beta member 2"]
["ENSRNOG00000010798",11,0.925487955,4,0.257321753,3.59661764,1.846640793,0.019203255,0.011357676,"up","yes","Blk","protein_coding","chr15:37627039-37665031:-","gi|672078356|ref|XP_008768991.1|",2575,0,"PREDICTED: tyrosine-protein kinase Blk isoform X2 [Rattus norvegicus]","gi|71043711|ref|NM_001025751.1|",2264,0,"Rattus norvegicus BLK proto-oncogene, Src family tyrosine kinase (Blk), mRNA","P16277",967,0,"Tyrosine-protein kinase Blk",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0002431|Fc receptor mediated stimulatory signaling pathway;GO:0002513|tolerance induction to self antigen;GO:0002576|platelet degranulation;GO:0002902|regulation of B cell apoptotic process;GO:0006974|cellular response to DNA damage stimulus;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0008150|biological_process;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0030154|cell differentiation;GO:0030889|negative regulation of B cell proliferation;GO:0031175|neuron projection development;GO:0032024|positive regulation of insulin secretion;GO:0032092|positive regulation of protein binding;GO:0043304|regulation of mast cell degranulation;GO:0045087|innate immune response;GO:0050853|B cell receptor signaling pathway;GO:0050855|regulation of B cell receptor signaling pathway;GO:0070667|negative regulation of mast cell proliferation;GO:0090330|regulation of platelet aggregation;GO:0097028|dendritic cell differentiation;GO:2000670|positive regulation of dendritic cell apoptotic process;","GO:0005575|cellular_component;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;","GO:0003674|molecular_function;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0005102|signaling receptor binding;GO:0005524|ATP binding;","K08890","BLK; B lymphoid tyrosine kinase [EC:2.7.10.2]"]
["ENSRNOG00000026306",11,0.925487955,4,0.257321753,3.59661764,1.846640793,0.019203255,0.011357676,"up","yes","Clec5a","protein_coding","chr4:69407835-69416859:-","gi|157820237|ref|NP_001102847.1|",1018,{"v":1E-134,"d":"1.00E-134"},"C-type lectin domain family 5 member A [Rattus norvegicus]","gi|157820236|ref|NM_001109377.1|",1391,0,"Rattus norvegicus C-type lectin domain family 5, member A (Clec5a), mRNA","Q9R007",340,{"v":5e-114,"d":"5.00E-114"},"C-type lectin domain family 5 member A",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0001819|positive regulation of cytokine production;GO:0002076|osteoblast development;GO:0030099|myeloid cell differentiation;GO:0033033|negative regulation of myeloid cell apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0045087|innate immune response;GO:0046718|viral entry into host cell;","GO:0005829|cytosol;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0001618|virus receptor activity;","K10073","CLEC5A; C-type lectin domain family 5 member A"]
["ENSRNOG00000053494",11,0.925487955,4,0.257321753,3.59661764,1.846640793,0.019203255,0.011357676,"up","yes","Mcpt1l1","protein_coding","chr15:29903980-29906645:-","gi|546015|gb|AAB30269.1|",1217,{"v":1E-165,"d":"1.00E-165"},"protease 1, partial [Rattus sp.]","gi|298916395|emb|FQ219938.1|",1029,0,"Rattus norvegicus TL0ADA44YN02 mRNA sequence","P09650",473,{"v":6e-167,"d":"6.00E-167"},"Mast cell protease 1","VC1649",67.4,{"v":2e-11,"d":"2.00E-11"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;",".",".","K01329","CMA1; chymase [EC:3.4.21.39]"]
["ENSRNOG00000065735",22,1.85097591,13,0.836295696,2.213303163,1.146201075,0.020304923,0.01194567,"up","yes","Dhrs9","protein_coding","chr3:54147803-54220241:+","gi|18677749|ref|NP_570832.1|",1609,0,"dehydrogenase/reductase SDR family member 9 precursor [Rattus norvegicus]","gi|18677748|ref|NM_130819.1|",1462,0,"Rattus norvegicus dehydrogenase/reductase (SDR family) member 9 (Dhrs9), mRNA","Q8VD48",624,0,"Dehydrogenase/reductase SDR family member 9",".",".",".",".","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.",".",".",".",".","."]
["ENSRNOG00000006281",16,1.346164298,8,0.514643505,2.61572192,1.387209175,0.021605641,0.012568866,"up","yes","Hoxa3","protein_coding","chr4:81269243-81313218:-","gi|564303758|ref|XP_006224990.1|",1598,0,"PREDICTED: homeobox protein Hox-A3 [Rattus norvegicus]","gi|672018319|ref|XM_006224929.2|",2338,0,"PREDICTED: Rattus norvegicus homeobox A3 (Hoxa3), transcript variant X3, mRNA","P02831",605,0,"Homeobox protein Hox-A3",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0001525|angiogenesis;GO:0001974|blood vessel remodeling;GO:0006357|regulation of transcription by RNA polymerase II;GO:0008284|positive regulation of cell proliferation;GO:0009887|animal organ morphogenesis;GO:0009952|anterior/posterior pattern specification;GO:0010159|specification of animal organ position;GO:0010467|gene expression;GO:0021615|glossopharyngeal nerve morphogenesis;GO:0030878|thyroid gland development;GO:0048538|thymus development;GO:0048645|animal organ formation;GO:0048704|embryonic skeletal system morphogenesis;GO:0048706|embryonic skeletal system development;GO:0051216|cartilage development;GO:0060017|parathyroid gland development;","GO:0005634|nucleus;GO:0005654|nucleoplasm;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003700|DNA-binding transcription factor activity;GO:0071837|HMG box domain binding;","K09303","HOX_3; homeobox protein HoxA/B/D3"]
["ENSRNOG00000009589",16,1.346164298,8,0.514643505,2.61572192,1.387209175,0.021605641,0.012568866,"up","yes","Angptl7","protein_coding","chr5:158932794-158937324:-","gi|564306469|ref|XP_006225684.1|",2038,0,"PREDICTED: angiopoietin-related protein 7 [Rattus norvegicus]","gi|672020127|ref|XM_006225622.2|",1632,0,"PREDICTED: Rattus norvegicus angiopoietin-related protein 7-like (LOC102552055), mRNA","Q8R1Q3",660,0,"Angiopoietin-related protein 7",".",".",".",".","pfam00147","Fibrinogen_C","Fibrinogen beta and gamma chains, C-terminal globular domain.","GO:1901346|negative regulation of vasculature development involved in avascular cornea development in camera-type eye;GO:1903053|regulation of extracellular matrix organization;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0062023|collagen-containing extracellular matrix;","GO:0005102|signaling receptor binding;GO:0042802|identical protein binding;","K25358","ANGPTL7; angiopoietin-related protein 7"]
["ENSRNOG00000014505",16,1.346164298,8,0.514643505,2.61572192,1.387209175,0.021605641,0.012568866,"up","yes","Pmfbp1","protein_coding","chr19:37458108-37507879:+","gi|672084711|ref|XP_006255636.2|",4332,0,"PREDICTED: polyamine-modulated factor 1-binding protein 1 isoform X4 [Rattus norvegicus]","gi|672084710|ref|XM_006255574.2|",3317,0,"PREDICTED: Rattus norvegicus polyamine modulated factor 1 binding protein 1 (Pmfbp1), transcript variant X3, mRNA","Q9Z221",1559,0,"Polyamine-modulated factor 1-binding protein 1",".",".",".",".","pfam01576","Myosin_tail_1","Myosin tail. The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.","GO:0007010|cytoskeleton organization;GO:0007283|spermatogenesis;","GO:0001520|outer dense fiber;GO:0005737|cytoplasm;GO:0097224|sperm connecting piece;",".","K23223","PMFBP1; polyamine-modulated factor 1-binding protein 1"]
["ENSRNOG00000024061",16,1.346164298,8,0.514643505,2.61572192,1.387209175,0.021605641,0.012568866,"up","yes","Rarb","protein_coding","chr15:8406492-9051288:+","gi|401461796|ref|NP_113717.1|",2161,0,"retinoic acid receptor beta [Rattus norvegicus]","gi|401461795|ref|NM_031529.1|",3092,0,"Rattus norvegicus retinoic acid receptor, beta (Rarb), mRNA","P22605",733,0,"Retinoic acid receptor beta",".",".",".",".","pfam00105","zf-C4","Zinc finger, C4 type (two domains). In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001657|ureteric bud development;GO:0002068|glandular epithelial cell development;GO:0003148|outflow tract septum morphogenesis;GO:0003406|retinal pigment epithelium development;GO:0003417|growth plate cartilage development;GO:0008284|positive regulation of cell proliferation;GO:0008285|negative regulation of cell proliferation;GO:0009755|hormone-mediated signaling pathway;GO:0021756|striatum development;GO:0022008|neurogenesis;GO:0030154|cell differentiation;GO:0031641|regulation of myelination;GO:0032331|negative regulation of chondrocyte differentiation;GO:0035116|embryonic hindlimb morphogenesis;GO:0035264|multicellular organism growth;GO:0043065|positive regulation of apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0043068|positive regulation of programmed cell death;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048048|embryonic eye morphogenesis;GO:0048384|retinoic acid receptor signaling pathway;GO:0048566|embryonic digestive tract development;GO:0055012|ventricular cardiac muscle cell differentiation;GO:0060041|retina development in camera-type eye;GO:0060348|bone development;GO:0061037|negative regulation of cartilage development;GO:0061351|neural precursor cell proliferation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0003700|DNA-binding transcription factor activity;GO:0004879|nuclear receptor activity;GO:0005515|protein binding;GO:0008270|zinc ion binding;GO:0043565|sequence-specific DNA binding;GO:0044877|protein-containing complex binding;GO:0046965|retinoid X receptor binding;GO:1901363|heterocyclic compound binding;GO:1990837|sequence-specific double-stranded DNA binding;","K08528","RARB, NR1B2; retinoic acid receptor beta"]
["ENSRNOG00000064154",16,1.346164298,8,0.514643505,2.61572192,1.387209175,0.021605641,0.012568866,"up","yes","Rassf10","protein_coding","chr1:167058099-167063572:+","gi|26338081|dbj|BAC32726.1|",2163,0,"unnamed protein product [Mus musculus]","gi|54888808|gb|AC110194.11|",3162,0,"Mus musculus chromosome 7, clone RP23-238J3, complete sequence","Q8BL43",747,0,"Ras association domain-containing protein 10",".",".",".",".","pfam00943","Alpha_E2_glycop","Alphavirus E2 glycoprotein. E2 forms a heterodimer with E1. The virus spikes are made up of 80 trimers of these heterodimers (sindbis virus).",".",".",".",".","."]
["ENSRNOG00000071088",16,1.346164298,8,0.514643505,2.61572192,1.387209175,0.021605641,0.012568866,"up","yes","ENSRNOG00000071088","lncRNA","chr5:141366115-141370274:+","gi|149048372|gb|EDM00948.1|",136,{"v":2e-06,"d":"2.00E-06"},"rCG62706 [Rattus norvegicus]","gi|22552760|emb|AL607086.19|",420,0,"Mouse DNA sequence from clone RP23-269B7 on chromosome 4, complete sequence",".",".",".",".",".",".",".",".","pfam01867","Cas_Cas1","CRISPR associated protein Cas1. Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein. Cas1 may be involved in linking DNA segments to CRISPR.",".",".",".",".","."]
["ENSRNOG00000004900",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","Crhr1","protein_coding","chr10:89040203-89083481:+","gi|13591892|ref|NP_112261.1|",1931,0,"corticotropin-releasing factor receptor 1 isoform 1 precursor [Rattus norvegicus]","gi|686661136|ref|NM_030999.4|",2478,0,"Rattus norvegicus corticotropin releasing hormone receptor 1 (Crhr1), transcript variant 1, mRNA","P35353",748,0,"Corticotropin-releasing factor receptor 1",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0001666|response to hypoxia;GO:0007166|cell surface receptor signaling pathway;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007188|adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007200|phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007218|neuropeptide signaling pathway;GO:0007613|memory;GO:0007631|feeding behavior;GO:0008542|visual learning;GO:0009755|hormone-mediated signaling pathway;GO:0010578|regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway;GO:0021854|hypothalamus development;GO:0030325|adrenal gland development;GO:0030855|epithelial cell differentiation;GO:0032811|negative regulation of epinephrine secretion;GO:0035641|locomotory exploration behavior;GO:0035902|response to immobilization stress;GO:0042596|fear response;GO:0043306|positive regulation of mast cell degranulation;GO:0043950|positive regulation of cAMP-mediated signaling;GO:0048148|behavioral response to cocaine;GO:0048149|behavioral response to ethanol;GO:0048167|regulation of synaptic plasticity;GO:0048266|behavioral response to pain;GO:0051458|corticotropin secretion;GO:0051602|response to electrical stimulus;GO:0051867|general adaptation syndrome, behavioral process;GO:0060291|long-term synaptic potentiation;GO:0071376|cellular response to corticotropin-releasing hormone stimulus;GO:1901215|negative regulation of neuron death;GO:1901386|negative regulation of voltage-gated calcium channel activity;GO:2000252|negative regulation of feeding behavior;GO:2000852|regulation of corticosterone secretion;","GO:0005771|multivesicular body;GO:0005802|trans-Golgi network;GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030425|dendrite;GO:0031226|intrinsic component of plasma membrane;GO:0031982|vesicle;GO:0043005|neuron projection;GO:0043025|neuronal cell body;GO:0045177|apical part of cell;","GO:0001965|G-protein alpha-subunit binding;GO:0004930|G protein-coupled receptor activity;GO:0005515|protein binding;GO:0008528|G protein-coupled peptide receptor activity;GO:0015056|corticotrophin-releasing factor receptor activity;GO:0017046|peptide hormone binding;GO:0042277|peptide binding;GO:0043404|corticotropin-releasing hormone receptor activity;GO:0044877|protein-containing complex binding;GO:0051424|corticotropin-releasing hormone binding;","K04578","CRHR1; corticotropin releasing hormone receptor 1"]
["ENSRNOG00000006306",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","Gip","protein_coding","chr10:80968352-80976503:+","gi|564373913|ref|XP_006247239.1|",716,{"v":1e-92,"d":"1.00E-92"},"PREDICTED: gastric inhibitory polypeptide isoform X2 [Rattus norvegicus]","gi|56235|emb|X66724.1|",644,0,"R.norvegicus mRNA for gastric inhibitory peptide (GIP)","Q06145",266,{"v":3e-89,"d":"3.00E-89"},"Gastric inhibitory polypeptide",".",".",".",".","pfam00123","Hormone_2","Peptide hormone. This family contains glucagon, GIP, secretin and VIP.","GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007565|female pregnancy;GO:0007613|memory;GO:0008344|adult locomotory behavior;GO:0009410|response to xenobiotic stimulus;GO:0009743|response to carbohydrate;GO:0009749|response to glucose;GO:0010269|response to selenium ion;GO:0010447|response to acidic pH;GO:0010828|positive regulation of glucose transmembrane transport;GO:0014070|response to organic cyclic compound;GO:0019233|sensory perception of pain;GO:0031018|endocrine pancreas development;GO:0031667|response to nutrient levels;GO:0032024|positive regulation of insulin secretion;GO:0033993|response to lipid;GO:0035640|exploration behavior;GO:0038192|gastric inhibitory peptide signaling pathway;GO:0042304|regulation of fatty acid biosynthetic process;GO:0042594|response to starvation;GO:0043200|response to amino acid;GO:0043434|response to peptide hormone;GO:0043950|positive regulation of cAMP-mediated signaling;GO:0048678|response to axon injury;GO:0050796|regulation of insulin secretion;GO:0050806|positive regulation of synaptic transmission;GO:0055123|digestive system development;GO:0060291|long-term synaptic potentiation;GO:0070094|positive regulation of glucagon secretion;GO:0070328|triglyceride homeostasis;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0043025|neuronal cell body;","GO:0005102|signaling receptor binding;GO:0005179|hormone activity;GO:0031767|gastric inhibitory polypeptide receptor binding;GO:0031769|glucagon receptor binding;","K05258","GIP; gastric inhibitory polypeptide"]
["ENSRNOG00000006311",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","Ccr9","protein_coding","chr8:123395813-123413969:+","gi|27229230|ref|NP_758832.1|",1756,0,"C-C chemokine receptor type 9 [Rattus norvegicus]","gi|60551362|gb|BC091115.1|",2472,0,"Rattus norvegicus chemokine (C-C motif) receptor 9, mRNA (cDNA clone MGC:108562 IMAGE:7381553), complete cds","Q9WUT7",674,0,"C-C chemokine receptor type 9",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0002305|CD8-positive, gamma-delta intraepithelial T cell differentiation;GO:0006935|chemotaxis;GO:0006955|immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0019722|calcium-mediated signaling;GO:0060326|cell chemotaxis;GO:0070098|chemokine-mediated signaling pathway;","GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0016493|C-C chemokine receptor activity;GO:0019957|C-C chemokine binding;","K04184","CCR9, CDw199; C-C chemokine receptor type 9"]
["ENSRNOG00000006658",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","Tmem269","protein_coding","chr5:132817324-132829977:-","gi|672053814|ref|XP_008762277.1|",1310,{"v":1E-175,"d":"1.00E-175"},"PREDICTED: uncharacterized protein LOC500537 isoform X1 [Rattus norvegicus]","gi|305410819|ref|NM_001134627.2|",1698,0,"Rattus norvegicus RGD1563015 (RGD1563015), mRNA","Q9D4Y8",449,{"v":3e-154,"d":"3.00E-154"},"Transmembrane protein 269",".",".",".",".","pfam01066","CDP-OH_P_transf","CDP-alcohol phosphatidyltransferase. All of these members have the ability to catalyse the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000006885",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","Dbx2","protein_coding","chr7:126772227-126802564:-","gi|109481229|ref|XP_001053826.1|",1701,0,"PREDICTED: homeobox protein DBX2 isoform X1 [Rattus norvegicus]","gi|672022319|ref|XM_001058743.4|",1455,0,"PREDICTED: Rattus norvegicus developing brain homeobox 2 (Dbx2), transcript variant X1, mRNA","Q6ZNG2",407,{"v":1E-136,"d":"1.00E-136"},"Homeobox protein DBX2",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0006357|regulation of transcription by RNA polymerase II;","GO:0005634|nucleus;","GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677|DNA binding;","K24875","DBX; homeobox protein DBX"]
["ENSRNOG00000008518",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","Gsg1","protein_coding","chr4:168090776-168107039:-","gi|123173794|ref|NP_001013184.2|",1800,0,"germ cell-specific gene 1 protein [Rattus norvegicus]","gi|61557155|ref|NM_001013166.1|",1349,0,"Rattus norvegicus germ cell associated 1 (Gsg1), mRNA","Q6AYL2",558,0,"Germ cell-specific gene 1 protein",".",".",".",".","pfam07803","GSG-1","GSG1-like protein. This family contains sequences bearing similarity to a region of GSG1, a protein specifically expressed in testicular germ cells. It is possible that overexpression of the human homolog may be involved in tumorigenesis of human testicular germ cell tumors. The region in question has four highly-conserved cysteine residues.",".","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0070063|RNA polymerase binding;",".","."]
["ENSRNOG00000008737",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","Tbc1d21","protein_coding","chr8:58761563-58773711:-","gi|62079147|ref|NP_001014232.1|",1799,0,"TBC1 domain family member 21 [Rattus norvegicus]","gi|62079146|ref|NM_001014210.1|",1218,0,"Rattus norvegicus TBC1 domain family, member 21 (Tbc1d21), mRNA","Q9D9D3",655,0,"TBC1 domain family member 21","SPAC630.05",91.7,{"v":5e-19,"d":"5.00E-19"},"COG5210","pfam00566","RabGAP-TBC","Rab-GTPase-TBC domain. Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.","GO:0006886|intracellular protein transport;GO:0090630|activation of GTPase activity;","GO:0001669|acrosomal vesicle;","GO:0003779|actin binding;GO:0005096|GTPase activator activity;","K24798","TBC1D21; TBC1 domain family member 21"]
["ENSRNOG00000012727",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","Trpc7","protein_coding","chr17:7709583-7833435:+","gi|966948818|ref|XP_014996393.1|",4387,0,"PREDICTED: short transient receptor potential channel 7 [Macaca mulatta]","gi|329755318|ref|NM_001191691.2|",3052,0,"Rattus norvegicus transient receptor potential cation channel, subfamily C, member 7 (Trpc7), mRNA","Q9WVC5",1667,0,"Short transient receptor potential channel 7",".",".",".",".","pfam08344","TRP_2","Transient receptor ion channel II. This domain is found in the transient receptor ion channel (Trp) family of proteins. There is strong evidence that Trp proteins are structural elements of calcium-ion entry channels activated by G protein-coupled receptors. This domain does not tend to appear with the TRP domain (pfam06011) but is often found to the C-terminus of Ankyrin repeats (pfam00023).","GO:0006816|calcium ion transport;GO:0006828|manganese ion transport;GO:0007338|single fertilization;GO:0051480|regulation of cytosolic calcium ion concentration;GO:0070588|calcium ion transmembrane transport;","GO:0005801|cis-Golgi network;GO:0005887|integral component of plasma membrane;GO:0034703|cation channel complex;GO:0048471|perinuclear region of cytoplasm;","GO:0005261|cation channel activity;GO:0005262|calcium channel activity;GO:0015279|store-operated calcium channel activity;GO:0070679|inositol 1,4,5 trisphosphate binding;","K04970","TRPC7; transient receptor potential cation channel subfamily C member 7"]
["ENSRNOG00000014039",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","Sucnr1","protein_coding","chr2:144219122-144230034:+","gi|48040447|ref|NP_001001518.1|",1661,0,"succinate receptor 1 [Rattus norvegicus]","gi|48040446|ref|NM_001001518.1|",954,0,"Rattus norvegicus succinate receptor 1 (Sucnr1), mRNA","Q6IYF9",644,0,"Succinate receptor 1",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0002001|renin secretion into blood stream;GO:0002281|macrophage activation involved in immune response;GO:0007186|G protein-coupled receptor signaling pathway;GO:0042593|glucose homeostasis;GO:0050729|positive regulation of inflammatory response;GO:0050921|positive regulation of chemotaxis;GO:0051592|response to calcium ion;GO:0060177|regulation of angiotensin metabolic process;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0038023|signaling receptor activity;","K10042","SUCNR1, GPR91; succinate receptor 1"]
["ENSRNOG00000015468",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","Bpifb1","protein_coding","chr3:142672995-142706256:+","gi|564343851|ref|XP_006235417.1|",2460,0,"PREDICTED: BPI fold-containing family B member 1 isoform X1 [Rattus norvegicus]","gi|672047608|ref|XM_006235355.2|",1555,0,"PREDICTED: Rattus norvegicus BPI fold containing family B, member 1 (Bpifb1), transcript variant X1, mRNA","A0JPN3",947,0,"BPI fold-containing family B member 1",".",".",".",".","pfam01273","LBP_BPI_CETP","LBP / BPI / CETP family, N-terminal domain. The N and C terminal domains of the LBP/BPI/CETP family are structurally similar.","GO:0002227|innate immune response in mucosa;GO:0034144|negative regulation of toll-like receptor 4 signaling pathway;","GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0008289|lipid binding;","K25376","BPIFB, LPLUNC; BPI fold-containing family B"]
["ENSRNOG00000016853",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","Dsg1","protein_coding","chr18:11674402-11703443:+","gi|672082860|ref|XP_008770215.1|",4803,0,"PREDICTED: LOW QUALITY PROTEIN: desmoglein-1 isoform X2 [Rattus norvegicus]","gi|672082859|ref|XM_008771993.1|",1947,0,"PREDICTED: Rattus norvegicus desmoglein 1 (Dsg1), transcript variant X2, mRNA","Q61495",1696,0,"Desmoglein-1-alpha",".",".",".",".","pfam00028","Cadherin","Cadherin domain.","GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0032570|response to progesterone;GO:0050821|protein stabilization;GO:0060135|maternal process involved in female pregnancy;GO:0098609|cell-cell adhesion;","GO:0005886|plasma membrane;GO:0005911|cell-cell junction;GO:0009898|cytoplasmic side of plasma membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0016328|lateral plasma membrane;GO:0030057|desmosome;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;GO:0045295|gamma-catenin binding;","K07596","DSG1; desmoglein 1"]
["ENSRNOG00000017256",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","Csprs","protein_coding","chr9:86166033-86173497:+","gi|564311898|ref|XP_006226973.1|",1498,0,"PREDICTED: olfactory receptor 13C8 isoform X1 [Rattus norvegicus]","gi|672024223|ref|XM_006226912.2|",1925,0,"PREDICTED: Rattus norvegicus component of Sp100-rs (Csprs), transcript variant X2, mRNA","Q99388",102,{"v":8e-23,"d":"8.00E-23"},"Component of Sp100-rs",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0050911|detection of chemical stimulus involved in sensory perception of smell;","GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004984|olfactory receptor activity;GO:0005549|odorant binding;",".","."]
["ENSRNOG00000019586",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","Ccdc24","protein_coding","chr5:131408143-131412029:-","gi|564352448|ref|XP_006238772.1|",1307,{"v":1E-173,"d":"1.00E-173"},"PREDICTED: coiled-coil domain-containing protein 24 isoform X4 [Rattus norvegicus]","gi|672053810|ref|XM_006238710.2|",1403,0,"PREDICTED: Rattus norvegicus coiled-coil domain containing 24 (Ccdc24), transcript variant X4, mRNA",".",".",".",".",".",".",".",".","pfam15258","FAM222A","Protein family of FAM222A. This protein family, FAM222A are a domain of unknown function. This family of proteins is found in eukaryotes and are typically between 411 and 562 amino acids in length. In humans, the gene encoding this protein domain lies in the position, chromosome 12 open reading frame 34.","GO:0001835|blastocyst hatching;",".",".",".","."]
["ENSRNOG00000021200",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","Hjv","protein_coding","chr2:184065970-184069850:+","gi|58865730|ref|NP_001012080.1|",1814,0,"hemojuvelin precursor [Rattus norvegicus]","gi|58865729|ref|NM_001012080.1|",2118,0,"Rattus norvegicus hemochromatosis type 2 (juvenile) (Hfe2), mRNA","Q8N7M5",701,0,"Hemojuvelin",".",".",".",".","pfam06534","RGM_C","Repulsive guidance molecule (RGM) C-terminus. This family consists of several mammalian and one bird sequence from Gallus gallus (Chicken). This family represents the C-terminal region of several sequences but in others it represents the full protein. All of the mammalian proteins are hypothetical and have no known function but RGMA from the chicken is annotated as being a repulsive guidance molecule (RGM). RGM is a GPI-linked axon guidance molecule of the retinotectal system. RGM is repulsive for a subset of axons, those from the temporal half of the retina. Temporal retinal axons invade the anterior optic tectum in a superficial layer, and encounter RGM expressed in a gradient with increasing concentration along the anterior-posterior axis. Temporal axons are able to receive posterior-dependent information by sensing gradients or concentrations of guidance cues. Thus, RGM is likely to provide positional information for temporal axons invading the optic tectum in the stratum opticum.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0006879|cellular iron ion homeostasis;GO:0008150|biological_process;GO:0016540|protein autoprocessing;GO:0030509|BMP signaling pathway;GO:0030514|negative regulation of BMP signaling pathway;GO:0032924|activin receptor signaling pathway;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0055072|iron ion homeostasis;GO:0071773|cellular response to BMP stimulus;","GO:0005615|extracellular space;GO:0005886|plasma membrane;GO:0009986|cell surface;GO:0016323|basolateral plasma membrane;GO:0031225|anchored component of membrane;GO:0070724|BMP receptor complex;GO:0098797|plasma membrane protein complex;GO:1990712|HFE-transferrin receptor complex;","GO:0003674|molecular_function;GO:0005102|signaling receptor binding;GO:0015026|coreceptor activity;GO:0036122|BMP binding;GO:0098821|BMP receptor activity;GO:1990459|transferrin receptor binding;","K23100","HJV, RGMC; hemojuvelin"]
["ENSRNOG00000022387",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","Olr1589","protein_coding","chr13:86102080-86108363:+","gi|47576439|ref|NP_001000083.1|",1630,0,"olfactory receptor Olr1589 [Rattus norvegicus]","gi|41469696|gb|AC113483.7|",956,0,"Mus musculus chromosome 1, clone RP23-343E12, complete sequence","Q8NGY5",545,0,"Olfactory receptor 6N1",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0050911|detection of chemical stimulus involved in sensory perception of smell;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004984|olfactory receptor activity;","K04257","OLFR; olfactory receptor"]
["ENSRNOG00000022777",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","Six1","protein_coding","chr6:91746739-91751975:-","gi|148704568|gb|EDL36515.1|",1414,0,"sine oculis-related homeobox 1 homolog (Drosophila), partial [Mus musculus]","gi|209954659|ref|NM_053759.1|",3188,0,"Rattus norvegicus SIX homeobox 1 (Six1), mRNA","Q62231",525,{"v":4e-177,"d":"4.00E-177"},"Homeobox protein SIX1",".",".",".",".","pfam05920","Homeobox_KN","Homeobox KN domain. This is a homeobox transcription factor KN domain conserved from fungi to human and plants.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0001657|ureteric bud development;GO:0001658|branching involved in ureteric bud morphogenesis;GO:0001759|organ induction;GO:0001822|kidney development;GO:0003151|outflow tract morphogenesis;GO:0006355|regulation of transcription, DNA-templated;GO:0006357|regulation of transcription by RNA polymerase II;GO:0006915|apoptotic process;GO:0007219|Notch signaling pathway;GO:0007382|specification of segmental identity, maxillary segment;GO:0007389|pattern specification process;GO:0007519|skeletal muscle tissue development;GO:0007605|sensory perception of sound;GO:0008582|regulation of synaptic growth at neuromuscular junction;GO:0010467|gene expression;GO:0010468|regulation of gene expression;GO:0014033|neural crest cell differentiation;GO:0014842|regulation of skeletal muscle satellite cell proliferation;GO:0014857|regulation of skeletal muscle cell proliferation;GO:0021610|facial nerve morphogenesis;GO:0022008|neurogenesis;GO:0030855|epithelial cell differentiation;GO:0030878|thyroid gland development;GO:0030910|olfactory placode formation;GO:0032880|regulation of protein localization;GO:0034504|protein localization to nucleus;GO:0035909|aorta morphogenesis;GO:0042472|inner ear morphogenesis;GO:0042474|middle ear morphogenesis;GO:0043066|negative regulation of apoptotic process;GO:0043524|negative regulation of neuron apoptotic process;GO:0043586|tongue development;GO:0045664|regulation of neuron differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048538|thymus development;GO:0048665|neuron fate specification;GO:0048699|generation of neurons;GO:0048701|embryonic cranial skeleton morphogenesis;GO:0048704|embryonic skeletal system morphogenesis;GO:0048705|skeletal system morphogenesis;GO:0048741|skeletal muscle fiber development;GO:0048839|inner ear development;GO:0048856|anatomical structure development;GO:0050678|regulation of epithelial cell proliferation;GO:0051451|myoblast migration;GO:0060037|pharyngeal system development;GO:0061055|myotome development;GO:0061197|fungiform papilla morphogenesis;GO:0061551|trigeminal ganglion development;GO:0071599|otic vesicle development;GO:0072075|metanephric mesenchyme development;GO:0072095|regulation of branch elongation involved in ureteric bud branching;GO:0072107|positive regulation of ureteric bud formation;GO:0072172|mesonephric tubule formation;GO:0072193|ureter smooth muscle cell differentiation;GO:0072513|positive regulation of secondary heart field cardioblast proliferation;GO:0086100|endothelin receptor signaling pathway;GO:0090103|cochlea morphogenesis;GO:0090190|positive regulation of branching involved in ureteric bud morphogenesis;GO:0090336|positive regulation of brown fat cell differentiation;GO:1905243|cellular response to 3,3',5-triiodo-L-thyronine;GO:2000729|positive regulation of mesenchymal cell proliferation involved in ureter development;GO:2001014|regulation of skeletal muscle cell differentiation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005667|transcription factor complex;GO:0005730|nucleolus;GO:0005737|cytoplasm;","GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001223|transcription coactivator binding;GO:0001228|DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677|DNA binding;GO:0003682|chromatin binding;GO:0003700|DNA-binding transcription factor activity;GO:0043565|sequence-specific DNA binding;GO:1990837|sequence-specific double-stranded DNA binding;","K15614","SIX1; homeobox protein SIX1"]
["ENSRNOG00000024527",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","ENSRNOG00000024527","protein_coding","chr12:11414479-11426457:+","gi|672072374|ref|XP_008767280.1|",1280,{"v":2e-164,"d":"2.00E-164"},"PREDICTED: putative olfactory receptor 10AC1 [Rattus norvegicus]","gi|672026573|ref|XM_008759142.1|",1027,0,"PREDICTED: Rattus norvegicus olfactory receptor 1572 (Olr1572), mRNA","Q8NGX6",205,{"v":4e-57,"d":"4.00E-57"},"Olfactory receptor 10R2",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0050911|detection of chemical stimulus involved in sensory perception of smell;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004984|olfactory receptor activity;","K04257","OLFR; olfactory receptor"]
["ENSRNOG00000027733",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","Lair1","protein_coding","chr1:70157681-70185807:+","gi|153945730|ref|NP_001025099.1|",1268,{"v":2e-172,"d":"2.00E-172"},"leukocyte-associated immunoglobulin-like receptor 1 precursor [Rattus norvegicus]","gi|672035182|ref|XM_008758974.1|",1148,0,"PREDICTED: Rattus norvegicus leukocyte-associated immunoglobulin-like receptor 1 (Lair1), transcript variant X1, mRNA","P0C1X9",493,{"v":6e-174,"d":"6.00E-174"},"Leukocyte-associated immunoglobulin-like receptor 1",".",".",".",".","pfam00047","ig","Immunoglobulin domain. Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions. The Pfam alignments do not include the first and last strand of the immunoglobulin-like domain.",".","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;",".","K06725","LAIR, CD305_6; leukocyte-associated Ig-like receptor"]
["ENSRNOG00000028598",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","Edar","protein_coding","chr20:26587839-26666494:-","gi|568966645|ref|XP_006513269.1|",2036,0,"PREDICTED: tumor necrosis factor receptor superfamily member EDAR isoform X3 [Mus musculus]","gi|672086280|ref|XM_006256381.2|",3625,0,"PREDICTED: Rattus norvegicus ectodysplasin-A receptor (Edar), transcript variant X1, mRNA","Q9R187",777,0,"Tumor necrosis factor receptor superfamily member EDAR",".",".",".",".","pfam00531","Death","Death domain.","GO:0001942|hair follicle development;GO:0008150|biological_process;GO:0010628|positive regulation of gene expression;GO:0042475|odontogenesis of dentin-containing tooth;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043473|pigmentation;GO:0046330|positive regulation of JNK cascade;GO:0060662|salivary gland cavitation;GO:1901224|positive regulation of NIK/NF-kappaB signaling;","GO:0005575|cellular_component;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0045177|apical part of cell;","GO:0003674|molecular_function;GO:0004888|transmembrane signaling receptor activity;GO:0038023|signaling receptor activity;","K05162","EDAR; tumor necrosis factor receptor superfamily member EDAR"]
["ENSRNOG00000029993",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","Kynu","protein_coding","chr3:27778772-27929488:+","gi|55584141|sp|P70712.2|KYNU_RAT",2372,0,"RecName: Full=Kynureninase; AltName: Full=L-kynurenine hydrolase","gi|51261162|gb|BC078762.1|",1438,0,"Rattus norvegicus kynureninase (L-kynurenine hydrolase), mRNA (cDNA clone MGC:93273 IMAGE:7128911), complete cds","P70712",918,0,"Kynureninase","YLR231c",320,{"v":3e-101,"d":"3.00E-101"},"COG3844","pfam00266","Aminotran_5","Aminotransferase class-V. This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.","GO:0006569|tryptophan catabolic process;GO:0007568|aging;GO:0009435|NAD biosynthetic process;GO:0019441|tryptophan catabolic process to kynurenine;GO:0019442|tryptophan catabolic process to acetyl-CoA;GO:0019805|quinolinate biosynthetic process;GO:0034341|response to interferon-gamma;GO:0034354|'de novo' NAD biosynthetic process from tryptophan;GO:0034516|response to vitamin B6;GO:0043420|anthranilate metabolic process;GO:0097053|L-kynurenine catabolic process;","GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0005829|cytosol;","GO:0030170|pyridoxal phosphate binding;GO:0030429|kynureninase activity;GO:0042803|protein homodimerization activity;GO:0061981|3-hydroxykynureninase activity;","K01556","KYNU, kynU; kynureninase [EC:3.7.1.3]"]
["ENSRNOG00000032329",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","AABR07029269.1","protein_coding","chr10:19003131-19022139:+","gi|672024670|ref|XP_008772938.1|",2579,0,"PREDICTED: protein FAM196B [Rattus norvegicus]","gi|672024669|ref|XM_008774716.1|",2602,0,"PREDICTED: Rattus norvegicus family with sequence similarity 196, member B (Fam196b), mRNA",".",".",".",".",".",".",".",".","pfam15265","FAM196","FAM196 family. This protein family is a domain of unknown function. This family of proteins is found in eukaryotes and are typically between 441 and 534 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000037149",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","Bcl2l15","protein_coding","chr2:191338959-191344078:+","gi|157824122|ref|NP_001099929.1|",884,{"v":2e-117,"d":"2.00E-117"},"bcl-2-like protein 15 [Rattus norvegicus]","gi|157824121|ref|NM_001106459.1|",850,0,"Rattus norvegicus BCL2-like 15 (Bcl2l15), mRNA","Q08ED0",268,{"v":7e-89,"d":"7.00E-89"},"Bcl-2-like protein 15",".",".",".",".","pfam00452","Bcl-2","Apoptosis regulator proteins, Bcl-2 family.","GO:0042981|regulation of apoptotic process;","GO:0005634|nucleus;GO:0005829|cytosol;",".",".","."]
["ENSRNOG00000037894",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","AABR07068042.1","protein_coding","chr9:73264478-73268630:+","gi|74179767|dbj|BAE22508.1|",357,{"v":1e-40,"d":"1.00E-40"},"unnamed protein product [Mus musculus]","gi|644986914|tpe|HG977898.1|",207,{"v":9E-103,"d":"9.00E-103"},"TPA: Mus musculus long non-coding RNA OTTMUST00000052539.2 (Apol7d gene), antisense",".",".",".",".",".",".",".",".","pfam04735","Baculo_helicase","Baculovirus DNA helicase.",".",".",".",".","."]
["ENSRNOG00000042468",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","ENSRNOG00000042468","protein_coding","chr9:12843566-12857392:+","gi|564367270|ref|XP_006244556.1|",714,{"v":3e-90,"d":"3.00E-90"},"PREDICTED: LOW QUALITY PROTEIN: triggering receptor expressed on myeloid cells 1-like isoform X2 [Rattus norvegicus]","gi|672064461|ref|XM_006244494.2|",830,0,"PREDICTED: Rattus norvegicus similar to natural cytotoxicity triggering receptor 2 (LOC680920), transcript variant X2, mRNA","Q6SJQ7",58.2,{"v":2E-8,"d":"2.00E-08"},"CMRF35-like molecule 1",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000046057",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","Pnmt","protein_coding","chr10:83384923-83386556:+","gi|149054109|gb|EDM05926.1|",1442,0,"rCG32571 [Rattus norvegicus]","gi|158081716|ref|NM_031526.1|",933,0,"Rattus norvegicus phenylethanolamine-N-methyltransferase (Pnmt), mRNA","P10937",556,0,"Phenylethanolamine N-methyltransferase",".",".",".",".","pfam01234","NNMT_PNMT_TEMT","NNMT/PNMT/TEMT family.","GO:0001666|response to hypoxia;GO:0009409|response to cold;GO:0009414|response to water deprivation;GO:0014823|response to activity;GO:0030325|adrenal gland development;GO:0031960|response to corticosteroid;GO:0032259|methylation;GO:0032868|response to insulin;GO:0035176|social behavior;GO:0035900|response to isolation stress;GO:0035902|response to immobilization stress;GO:0042415|norepinephrine metabolic process;GO:0042418|epinephrine biosynthetic process;GO:0043434|response to peptide hormone;GO:0045471|response to ethanol;GO:0045472|response to ether;GO:0046498|S-adenosylhomocysteine metabolic process;GO:0046500|S-adenosylmethionine metabolic process;GO:0050909|sensory perception of taste;GO:0071363|cellular response to growth factor stimulus;GO:0071375|cellular response to peptide hormone stimulus;GO:0071549|cellular response to dexamethasone stimulus;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0030424|axon;GO:0030425|dendrite;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0043196|varicosity;GO:0043204|perikaryon;","GO:0004603|phenylethanolamine N-methyltransferase activity;GO:0008168|methyltransferase activity;GO:0008170|N-methyltransferase activity;GO:0008757|S-adenosylmethionine-dependent methyltransferase activity;GO:0016740|transferase activity;","K00553","PNMT; phenylethanolamine N-methyltransferase [EC:2.1.1.28]"]
["ENSRNOG00000047730",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","Tnfsf14","protein_coding","chr9:2069104-2073216:-","gi|972854014|tpe|CTQ86172.1|",1463,0,"TPA: tumor necrosis factor ligand 1d [Rattus norvegicus]","gi|972854013|tpe|LN874407.1|",936,0,"TPA_inf: Rattus norvegicus mRNA for tumor necrosis factor ligand 1d (Tnlg1d gene)","Q9QYH9",444,{"v":6e-155,"d":"6.00E-155"},"Tumor necrosis factor ligand superfamily member 14",".",".",".",".","pfam00229","TNF","TNF(tumor Necrosis Factor) family.","GO:0006915|apoptotic process;GO:0006955|immune response;GO:0010820|positive regulation of T cell chemotaxis;GO:0031295|T cell costimulation;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045663|positive regulation of myoblast differentiation;GO:0071260|cellular response to mechanical stimulus;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:1901741|positive regulation of myoblast fusion;","GO:0016021|integral component of membrane;","GO:0005102|signaling receptor binding;GO:0005164|tumor necrosis factor receptor binding;GO:0042802|identical protein binding;GO:0043027|cysteine-type endopeptidase inhibitor activity involved in apoptotic process;","K05477","TNFSF14, LIGHT, CD258; tumor necrosis factor ligand superfamily member 14"]
["ENSRNOG00000049392",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","Sowahd","protein_coding","chrX:116292030-116293660:+","gi|290560662|ref|NP_001166844.1|",1308,{"v":6E-175,"d":"6.00E-175"},"ankyrin repeat domain-containing protein SOWAHD [Rattus norvegicus]","gi|290560661|ref|NM_001173373.1|",1631,0,"Rattus norvegicus sosondowah ankyrin repeat domain family member D (Sowahd), mRNA",".",".",".",".",".",".",".",".","pfam12796","Ank_2","Ankyrin repeats (3 copies).",".",".",".",".","."]
["ENSRNOG00000049919",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","ENSRNOG00000049919","protein_coding","chr15:29986103-29988926:-","gi|157820605|ref|NP_001103116.1|",1137,{"v":4e-155,"d":"4.00E-155"},"uncharacterized protein LOC691670 precursor [Rattus norvegicus]","gi|157820604|ref|NM_001109646.1|",748,0,"Rattus norvegicus similar to natural killer cell protease 7 (LOC691670), mRNA","P13366",302,{"v":1e-101,"d":"1.00E-101"},"Granzyme G","VC1200",83.6,{"v":1e-17,"d":"1.00E-17"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;","GO:0005737|cytoplasm;GO:0043231|intracellular membrane-bounded organelle;","GO:0004252|serine-type endopeptidase activity;",".","."]
["ENSRNOG00000049949",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","Hapln4","protein_coding","chr16:19333106-19341243:-","gi|625290168|ref|XP_007636838.1|",1631,0,"PREDICTED: hyaluronan and proteoglycan link protein 4 isoform X2 [Cricetulus griseus]","gi|157822056|ref|NM_001108398.1|",3687,0,"Rattus norvegicus hyaluronan and proteoglycan link protein 4 (Hapln4), mRNA","Q80WM4",604,0,"Hyaluronan and proteoglycan link protein 4",".",".",".",".","pfam00193","Xlink","Extracellular link domain.","GO:0001501|skeletal system development;GO:0007155|cell adhesion;GO:0007417|central nervous system development;","GO:0005576|extracellular region;GO:0031012|extracellular matrix;","GO:0005540|hyaluronic acid binding;","K06853","HAPLN4; hyaluronan and proteoglycan link protein 4"]
["ENSRNOG00000051489",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","Klra1","protein_coding","chr4:164606629-164628406:-","gi|57527630|ref|NP_001009718.1|",1404,0,"killer cell lectin-like receptor, subfamily A, member 2 [Rattus norvegicus]","gi|57527629|ref|NM_001009718.1|",1162,0,"Rattus norvegicus killer cell lectin-like receptor, subfamily A, member 2 (Klra2), mRNA","Q60652",350,{"v":6e-118,"d":"6.00E-118"},"Killer cell lectin-like receptor 5",".",".",".",".","pfam08391","Ly49","Ly49-like protein, N-terminal region. The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000052520",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","AABR07072195.1","snRNA","chr10:90223339-90223431:-",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","pfam08167","RIX1","rRNA processing/ribosome biogenesis. Rix1 is a nucleoplasmic particle involved in rRNA processing/ribosome assembly. It associates with two other proteins, Ipi1 and Ipi3, to form the RIX1 complex that allows Rea1 - the AAA ATPase - to associate with the 60S ribosomal subunit. More than 170 assembly factors are involved in the construction and maturation of yeast ribosomes, and after these factors have completed their function they need to be released from the pre-ribosomes. Rea1 induces the release of the assembly protein complex in a mechanical fashion. This family is usually associated with NUC202, pfam08166.",".",".",".",".","."]
["ENSRNOG00000057499",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","AABR07068587.1","pseudogene","chr9:102319963-102320325:-","gi|26341650|dbj|BAC34487.1|",434,{"v":1E-52,"d":"1.00E-52"},"unnamed protein product [Mus musculus]","gi|672066109|ref|XM_006245593.2|",306,{"v":7e-158,"d":"7.00E-158"},"PREDICTED: Rattus norvegicus ephrin A5 (Efna5), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam10719","ComFB","Late competence development protein ComFB. This family is conserved in bacteria. Some members, with three conserved cysteines, are annotated as late competence development protein ComFB.",".",".",".",".","."]
["ENSRNOG00000059604",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","Loricrin","protein_coding","chr2:177558252-177559807:-",".",".",".",".","gi|672043261|ref|XM_008761253.1|",1027,0,"PREDICTED: Rattus norvegicus loricrin (Lor), transcript variant X2, mRNA",".",".",".",".",".",".",".",".",".",".",".","GO:0018149|peptide cross-linking;GO:0030216|keratinocyte differentiation;","GO:0001533|cornified envelope;GO:0005737|cytoplasm;GO:0009898|cytoplasmic side of plasma membrane;","GO:0005200|structural constituent of cytoskeleton;GO:0030280|structural constituent of epidermis;","K10385","LOR; loricrin"]
["ENSRNOG00000059842",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","AABR07012588.1","protein_coding","chr2:184019212-184019587:+","gi|74203709|dbj|BAE23096.1|",215,{"v":8e-21,"d":"8.00E-21"},"unnamed protein product [Mus musculus]","gi|755505303|ref|XR_867480.1|",101,{"v":4e-44,"d":"4.00E-44"},"PREDICTED: Mus musculus uncharacterized LOC102632901 (LOC102632901), transcript variant X8, misc_RNA",".",".",".",".",".",".",".",".","pfam09815","XK-related","XK-related protein. Members of this family comprise various XK-related proteins, that are involved in sodium-dependent transport of neutral amino acids or oligopeptides. These proteins are responsible for the Kx blood group system - defects results in McLeod syndrome, an X-linked multi-system disorder characterized by late onset abnormalities in the neuromuscular and hematopoietic systems.",".",".",".",".","."]
["ENSRNOG00000062446",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","ENSRNOG00000062446","lncRNA","chr2:59942763-59946060:-","gi|37654330|gb|AAQ96270.1|",289,{"v":4e-26,"d":"4.00E-26"},"LRRGT00057 [Rattus norvegicus]","gi|28570530|gb|AC122330.4|",127,{"v":2e-57,"d":"2.00E-57"},"Mus musculus BAC clone RP23-342G7 from chromosome 18, complete sequence","P11369",109,{"v":1E-25,"d":"1.00E-25"},"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam03360","Glyco_transf_43","Glycosyltransferase family 43.",".",".",".",".","."]
["ENSRNOG00000063669",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","Stfa2l2","protein_coding","chr11:64498206-64500574:+","gi|564314487|ref|XP_006221214.1|",543,{"v":5e-69,"d":"5.00E-69"},"PREDICTED: stefin-2-like isoform X2 [Rattus norvegicus]","gi|672026106|ref|XM_006221152.2|",400,0,"PREDICTED: Rattus norvegicus stefin A2-like 3 (Stfa2l3), transcript variant X2, mRNA","P35174",162,{"v":2E-50,"d":"2.00E-50"},"Stefin-2",".",".",".",".","pfam00031","Cystatin","Cystatin domain. Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 are related to this family but have not been included.",".",".",".",".","."]
["ENSRNOG00000064325",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","ENSRNOG00000064325","lncRNA","chr12:32553104-32559941:-","gi|148701441|gb|EDL33388.1|",245,{"v":3e-21,"d":"3.00E-21"},"mCG1045525, partial [Mus musculus]","gi|672026716|ref|XR_590679.1|",585,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102552690 (LOC102552690), ncRNA",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSRNOG00000067850",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","ENSRNOG00000067850","protein_coding","chr2:120910598-120912239:-","gi|354486538|ref|XP_003505437.1|",1458,0,"PREDICTED: D-3-phosphoglycerate dehydrogenase [Cricetulus griseus]","gi|564338012|ref|XM_006233010.1|",482,0,"PREDICTED: Rattus norvegicus phosphoglycerate dehydrogenase (Phgdh), transcript variant X1, mRNA","Q61753",562,0,"D-3-phosphoglycerate dehydrogenase","MJ1018",271,{"v":1E-83,"d":"1.00E-83"},"COG0111","pfam00389","2-Hacid_dh","D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. This family represents the largest portion of the catalytic domain of 2-hydroxyacid dehydrogenases as the NAD binding domain is inserted within the structural domain.",".",".",".",".","."]
["ENSRNOG00000069444",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","ENSRNOG00000069444","protein_coding","chr6:134596525-134597057:-","gi|344257616|gb|EGW13720.1|",413,{"v":5e-49,"d":"5.00E-49"},"Ig heavy chain V region M315 [Cricetulus griseus]","gi|62201946|gb|BC092582.1|",173,{"v":7e-84,"d":"7.00E-84"},"Rattus norvegicus similar to single chain Fv antibody fragment scFv 7-10A, mRNA (cDNA clone IMAGE:7373926)","P18531",145,{"v":1e-43,"d":"1.00E-43"},"Ig heavy chain V region 3-6",".",".",".",".","pfam04299","FMN_bind_2","Putative FMN-binding domain. In Bacillus subtilis, family member PAI 2/ORF-2 was found to be essential for growth. The SUPERFAMILY database finds that this domain is related to FMN-binding domains, suggesting this protein is also FMN-binding.",".",".",".",".","."]
["ENSRNOG00000070279",5,0.420676343,0,0.032165219,13.0786096,3.70913727,0.021661997,0.012568866,"up","yes","ENSRNOG00000070279","protein_coding","chr3:75123279-75124251:+","gi|470632967|ref|XP_004322437.1|",505,{"v":6e-63,"d":"6.00E-63"},"PREDICTED: copine-8-like, partial [Tursiops truncatus]","gi|371905553|emb|AM747284.1|",293,{"v":1E-150,"d":"1.00E-150"},"Rattus norvegicus mRNA for copine 8 protein (Cpne8 gene)",".",".",".",".",".",".",".",".","pfam07002","Copine","Copine. This family represents a conserved region approximately 180 residues long within eukaryotic copines. Copines are Ca(2+)-dependent phospholipid-binding proteins that are thought to be involved in membrane-trafficking, and may also be involved in cell division and growth.",".",".",".",".","."]
["ENSRNOG00000003164",6,0.504811612,1,0.064330438,7.84716576,2.972171675,0.022010268,0.012738363,"up","yes","Pla2g10","protein_coding","chr10:1597761-1609000:-","gi|149042532|gb|EDL96169.1|",703,{"v":1E-87,"d":"1.00E-87"},"phospholipase A2, group X, isoform CRA_a [Rattus norvegicus]","gi|402745647|ref|NM_017176.2|",785,0,"Rattus norvegicus phospholipase A2, group X (Pla2g10), mRNA","Q9QZT3",271,{"v":7e-88,"d":"7.00E-88"},"Group 10 secretory phospholipase A2",".",".",".",".","pfam00068","Phospholip_A2_1","Phospholipase A2. Phospholipase A2 releases fatty acids from the second carbon group of glycerol. Perhaps the best known members are secreted snake venoms, but also found in secreted pancreatic and membrane-associated forms. Structure is all-alpha, with two core disulfide-linked helices and a calcium-binding loop. This alignment represents the major family of PLA2s. A second minor family, defined by the honeybee venom PLA2 PDB:1POC and related sequences from Gila monsters (Heloderma), is not recognized. This minor family conserves the core helix pair but is substantially different elsewhere. The PROSITE pattern PA2_HIS, specific to the first core helix, recognizes both families.","GO:0001516|prostaglandin biosynthetic process;GO:0002532|production of molecular mediator involved in inflammatory response;GO:0006644|phospholipid metabolic process;GO:0006658|phosphatidylserine metabolic process;GO:0007411|axon guidance;GO:0009566|fertilization;GO:0010884|positive regulation of lipid storage;GO:0031069|hair follicle morphogenesis;GO:0032270|positive regulation of cellular protein metabolic process;GO:0032308|positive regulation of prostaglandin secretion;GO:0034374|low-density lipoprotein particle remodeling;GO:0034638|phosphatidylcholine catabolic process;GO:0036335|intestinal stem cell homeostasis;GO:0042116|macrophage activation;GO:0042632|cholesterol homeostasis;GO:0043030|regulation of macrophage activation;GO:0043249|erythrocyte maturation;GO:0043433|negative regulation of DNA-binding transcription factor activity;GO:0046337|phosphatidylethanolamine metabolic process;GO:0046470|phosphatidylcholine metabolic process;GO:0046471|phosphatidylglycerol metabolic process;GO:0046473|phosphatidic acid metabolic process;GO:0050482|arachidonic acid secretion;GO:0050728|negative regulation of inflammatory response;GO:0051607|defense response to virus;GO:0051977|lysophospholipid transport;GO:0090238|positive regulation of arachidonic acid secretion;GO:0090370|negative regulation of cholesterol efflux;GO:1900016|negative regulation of cytokine production involved in inflammatory response;GO:1990830|cellular response to leukemia inhibitory factor;GO:2000344|positive regulation of acrosome reaction;","GO:0001669|acrosomal vesicle;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005764|lysosome;","GO:0003847|1-alkyl-2-acetylglycerophosphocholine esterase activity;GO:0004620|phospholipase activity;GO:0004623|phospholipase A2 activity;GO:0005509|calcium ion binding;GO:0005543|phospholipid binding;GO:0047498|calcium-dependent phospholipase A2 activity;","K01047","PLA2G, SPLA2; secretory phospholipase A2 [EC:3.1.1.4]"]
["ENSRNOG00000004142",6,0.504811612,1,0.064330438,7.84716576,2.972171675,0.022010268,0.012738363,"up","yes","Efcab9","protein_coding","chr10:17107123-17112289:-","gi|300797666|ref|NP_001178020.1|",914,{"v":1e-121,"d":"1.00E-121"},"EF-hand calcium-binding domain-containing protein 9 [Rattus norvegicus]","gi|672067102|ref|XM_003750798.3|",759,0,"PREDICTED: Rattus norvegicus EF-hand calcium-binding domain-containing protein 9-like (LOC100911628), mRNA","Q9DAM2",333,{"v":3e-114,"d":"3.00E-114"},"EF-hand calcium-binding domain-containing protein 9",".",".",".",".","pfam13499","EF-hand_7","EF-hand domain pair.","GO:0007283|spermatogenesis;GO:0030317|flagellated sperm motility;GO:0048240|sperm capacitation;","GO:0005737|cytoplasm;GO:0097228|sperm principal piece;","GO:0005509|calcium ion binding;GO:0061891|calcium ion sensor activity;","K25646","EFCAB9; EF-hand calcium-binding domain-containing protein 9"]
["ENSRNOG00000009556",6,0.504811612,1,0.064330438,7.84716576,2.972171675,0.022010268,0.012738363,"up","yes","Prokr1","protein_coding","chr4:120021747-120033379:-","gi|20376822|ref|NP_620433.1|",1901,0,"prokineticin receptor 1 [Rattus norvegicus]","gi|672050135|ref|XM_006236821.2|",2909,0,"PREDICTED: Rattus norvegicus prokineticin receptor 1 (Prokr1), transcript variant X1, mRNA","Q8R416",736,0,"Prokineticin receptor 1",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007186|G protein-coupled receptor signaling pathway;GO:0007218|neuropeptide signaling pathway;GO:0043066|negative regulation of apoptotic process;","GO:0005575|cellular_component;GO:0005887|integral component of plasma membrane;","GO:0004930|G protein-coupled receptor activity;GO:0004983|neuropeptide Y receptor activity;","K08379","PROKR1; prokineticin receptor 1"]
["ENSRNOG00000013615",6,0.504811612,1,0.064330438,7.84716576,2.972171675,0.022010268,0.012738363,"up","yes","Dntt","protein_coding","chr1:239856391-239888282:+","gi|60223047|ref|NP_001012479.1|",2582,0,"DNA nucleotidylexotransferase [Rattus norvegicus]","gi|60223046|ref|NM_001012461.1|",1822,0,"Rattus norvegicus DNA nucleotidylexotransferase (Dntt), mRNA","P09838",900,0,"DNA nucleotidylexotransferase","SPAC2F7.06c",131,{"v":5e-32,"d":"5.00E-32"},"COG1796","pfam14791","DNA_pol_B_thumb","DNA polymerase beta thumb. The catalytic region of DNA polymerase beta is split into three domains. An N-terminal fingers domain, a central palm domain and a C-terminal thumb domain. This entry represents the thumb domain.","GO:0006259|DNA metabolic process;GO:0006303|double-strand break repair via nonhomologous end joining;GO:0006304|DNA modification;GO:0033198|response to ATP;GO:0071897|DNA biosynthetic process;","GO:0000785|chromatin;GO:0000791|euchromatin;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016363|nuclear matrix;","GO:0003677|DNA binding;GO:0003887|DNA-directed DNA polymerase activity;GO:0003912|DNA nucleotidylexotransferase activity;GO:0046872|metal ion binding;","K00977","DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]"]
["ENSRNOG00000020778",6,0.504811612,1,0.064330438,7.84716576,2.972171675,0.022010268,0.012738363,"up","yes","Chrnb2","protein_coding","chr2:175181402-175189619:-","gi|9506485|ref|NP_062170.1|",2546,0,"neuronal acetylcholine receptor subunit beta-2 precursor [Rattus norvegicus]","gi|9506484|ref|NM_019297.1|",2188,0,"Rattus norvegicus cholinergic receptor nicotinic beta 2 subunit (Chrnb2), mRNA","P12390",982,0,"Neuronal acetylcholine receptor subunit beta-2",".",".",".",".","pfam02931","Neur_chan_LBD","Neurotransmitter-gated ion-channel ligand binding domain. This family is the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.","GO:0001508|action potential;GO:0001661|conditioned taste aversion;GO:0001666|response to hypoxia;GO:0006816|calcium ion transport;GO:0006939|smooth muscle contraction;GO:0007165|signal transduction;GO:0007268|chemical synaptic transmission;GO:0007271|synaptic transmission, cholinergic;GO:0007601|visual perception;GO:0007605|sensory perception of sound;GO:0007612|learning;GO:0007613|memory;GO:0007626|locomotory behavior;GO:0008306|associative learning;GO:0008542|visual learning;GO:0014059|regulation of dopamine secretion;GO:0019233|sensory perception of pain;GO:0021562|vestibulocochlear nerve development;GO:0021631|optic nerve morphogenesis;GO:0021771|lateral geniculate nucleus development;GO:0021952|central nervous system projection neuron axonogenesis;GO:0021955|central nervous system neuron axonogenesis;GO:0030890|positive regulation of B cell proliferation;GO:0032225|regulation of synaptic transmission, dopaminergic;GO:0032226|positive regulation of synaptic transmission, dopaminergic;GO:0033603|positive regulation of dopamine secretion;GO:0034220|ion transmembrane transport;GO:0035094|response to nicotine;GO:0035095|behavioral response to nicotine;GO:0035176|social behavior;GO:0042053|regulation of dopamine metabolic process;GO:0042113|B cell activation;GO:0042220|response to cocaine;GO:0042320|regulation of circadian sleep/wake cycle, REM sleep;GO:0042391|regulation of membrane potential;GO:0045188|regulation of circadian sleep/wake cycle, non-REM sleep;GO:0045471|response to ethanol;GO:0045759|negative regulation of action potential;GO:0048814|regulation of dendrite morphogenesis;GO:0050877|nervous system process;GO:0050890|cognition;GO:0051899|membrane depolarization;GO:0051963|regulation of synapse assembly;GO:0060079|excitatory postsynaptic potential;GO:0060084|synaptic transmission involved in micturition;GO:0095500|acetylcholine receptor signaling pathway;GO:1905144|response to acetylcholine;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005892|acetylcholine-gated channel complex;GO:0009897|external side of plasma membrane;GO:0016020|membrane;GO:0032991|protein-containing complex;GO:0043005|neuron projection;GO:0044853|plasma membrane raft;GO:0045202|synapse;GO:0098691|dopaminergic synapse;GO:0098981|cholinergic synapse;GO:0099056|integral component of presynaptic membrane;GO:0099060|integral component of postsynaptic specialization membrane;","GO:0005515|protein binding;GO:0015464|acetylcholine receptor activity;GO:0022848|acetylcholine-gated cation-selective channel activity;GO:0030594|neurotransmitter receptor activity;GO:0042166|acetylcholine binding;GO:0044877|protein-containing complex binding;GO:1904315|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;","K04813","CHRNB2; nicotinic acetylcholine receptor beta-2"]
["ENSRNOG00000022784",6,0.504811612,1,0.064330438,7.84716576,2.972171675,0.022010268,0.012738363,"up","yes","Fzd10","protein_coding","chr12:28098371-28101566:-","gi|403225021|ref|NP_001258121.1|",3069,0,"frizzled-10 precursor [Rattus norvegicus]","gi|403225020|ref|NM_001271192.1|",3196,0,"Rattus norvegicus frizzled class receptor 10 (Fzd10), mRNA","Q8BKG4",1172,0,"Frizzled-10",".",".",".",".","pfam01534","Frizzled","Frizzled/Smoothened family membrane region. This family contains the membrane spanning region of frizzled and smoothened receptors. This membrane region is predicted to contain seven transmembrane alpha helices. Proteins related to Drosophila frizzled are receptors for Wnt (mediating the beta-catenin signalling pathway), but also the planar cell polarity (PCP) pathway and the Wnt/calcium pathway. The predominantly alpha-helical Cys-rich ligand-binding region (CRD) of Frizzled is both necessary and sufficient for Wnt binding. The smoothened receptor mediates hedgehog signalling.","GO:0008150|biological_process;GO:0016055|Wnt signaling pathway;GO:0032956|regulation of actin cytoskeleton organization;GO:0034260|negative regulation of GTPase activity;GO:0038031|non-canonical Wnt signaling pathway via JNK cascade;GO:0043507|positive regulation of JUN kinase activity;GO:0043547|positive regulation of GTPase activity;GO:0060070|canonical Wnt signaling pathway;","GO:0005575|cellular_component;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0009986|cell surface;","GO:0003674|molecular_function;GO:0017147|Wnt-protein binding;GO:0042813|Wnt-activated receptor activity;","K02842","FZD9_10, CD349_50; frizzled 9/10"]
["ENSRNOG00000025059",6,0.504811612,1,0.064330438,7.84716576,2.972171675,0.022010268,0.012738363,"up","yes","Nxph4","protein_coding","chr7:63367761-63376579:-","gi|52345439|ref|NP_067712.2|",1227,{"v":1e-163,"d":"1.00E-163"},"neurexophilin-4 precursor [Rattus norvegicus]","gi|52345438|ref|NM_021680.2|",1547,0,"Rattus norvegicus neurexophilin 4 (Nxph4), mRNA","Q9Z2N4",476,{"v":1e-164,"d":"1.00E-164"},"Neurexophilin-4",".",".",".",".","pfam06312","Neurexophilin","Neurexophilin. This family consists of mammalian neurexophilin proteins. Mammalian brains contain four different neurexophilin proteins. Neurexophilins form a family of related glycoproteins that are proteolytically processed after synthesis and bind to alpha-neurexins. The structure and characteristics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins.",".","GO:0005576|extracellular region;","GO:0005102|signaling receptor binding;","K25711","NXPH4; neurexophilin-4"]
["ENSRNOG00000036726",6,0.504811612,1,0.064330438,7.84716576,2.972171675,0.022010268,0.012738363,"up","yes","Cd300e","protein_coding","chr10:100291437-100299311:-","gi|262205519|ref|NP_001160049.1|",995,{"v":2e-134,"d":"2.00E-134"},"CMRF35-like molecule 2 precursor [Rattus norvegicus]","gi|672069895|ref|XM_008768395.1|",722,0,"PREDICTED: Rattus norvegicus Cd300e molecule (Cd300e), transcript variant X2, mRNA","Q8K249",266,{"v":4e-88,"d":"4.00E-88"},"CMRF35-like molecule 2",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0004888|transmembrane signaling receptor activity;","K06719","CD300; CD300 antigen"]
["ENSRNOG00000036834",6,0.504811612,1,0.064330438,7.84716576,2.972171675,0.022010268,0.012738363,"up","yes","Gpr84","protein_coding","chr7:134443936-134446178:-","gi|157824113|ref|NP_001102979.1|",1870,0,"G-protein coupled receptor 84 [Rattus norvegicus]","gi|672060304|ref|XM_006242448.2|",1509,0,"PREDICTED: Rattus norvegicus G protein-coupled receptor 84 (Gpr84), transcript variant X1, mRNA","Q8CIM5",687,0,"G-protein coupled receptor 84",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007218|neuropeptide signaling pathway;","GO:0005887|integral component of plasma membrane;GO:0043235|receptor complex;","GO:0001604|urotensin II receptor activity;GO:0008528|G protein-coupled peptide receptor activity;","K08421","GPR84; G protein-coupled receptor 84"]
["ENSRNOG00000053071",6,0.504811612,1,0.064330438,7.84716576,2.972171675,0.022010268,0.012738363,"up","yes","SNORA70","snoRNA","chr5:115961775-115961902:+",".",".",".",".","gi|21621612|emb|AL645668.15|",43,{"v":4e-12,"d":"4.00E-12"},"Mouse DNA sequence from clone RP23-32L21 on chromosome 4, complete sequence",".",".",".",".",".",".",".",".","pfam01314","AFOR_C","Aldehyde ferredoxin oxidoreductase, domains 2 & 3. Aldehyde ferredoxin oxidoreductase (AOR) catalyses the reversible oxidation of aldehydes to their corresponding carboxylic acids with their accompanying reduction of the redox protein ferredoxin. This family is composed of two structural domains that bind the tungsten cofactor via DXXGL(C/D) motifs. In addition to maintaining specific binding interactions with the cofactor, another role for domains 2 and 3 may be to regulate substrate access to AOR.",".",".",".",".","."]
["ENSRNOG00000059479",6,0.504811612,1,0.064330438,7.84716576,2.972171675,0.022010268,0.012738363,"up","yes","Adcy1","protein_coding","chr14:81911099-82028969:+","gi|672076819|ref|XP_008768543.1|",5183,0,"PREDICTED: adenylate cyclase type 1 isoform X2 [Rattus norvegicus]","gi|672076818|ref|XM_008770321.1|",6410,0,"PREDICTED: Rattus norvegicus adenylate cyclase 1 (brain) (Adcy1), transcript variant X2, mRNA","O88444",1975,0,"Adenylate cyclase type 1","all0661",149,{"v":4e-36,"d":"4.00E-36"},"COG2114","pfam00211","Guanylate_cyc","Adenylate and Guanylate cyclase catalytic domain.","GO:0006171|cAMP biosynthetic process;GO:0007189|adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007409|axonogenesis;GO:0007420|brain development;GO:0007616|long-term memory;GO:0007623|circadian rhythm;GO:0009410|response to xenobiotic stimulus;GO:0010226|response to lithium ion;GO:0032793|positive regulation of CREB transcription factor activity;GO:0035556|intracellular signal transduction;GO:0042752|regulation of circadian rhythm;GO:0050804|modulation of chemical synaptic transmission;GO:0150076|neuroinflammatory response;GO:1900273|positive regulation of long-term synaptic potentiation;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0014069|postsynaptic density;GO:0098685|Schaffer collateral - CA1 synapse;GO:0098686|hippocampal mossy fiber to CA3 synapse;GO:0098978|glutamatergic synapse;GO:0099061|integral component of postsynaptic density membrane;","GO:0004016|adenylate cyclase activity;GO:0005524|ATP binding;GO:0008294|calcium- and calmodulin-responsive adenylate cyclase activity;GO:0046872|metal ion binding;","K08041","ADCY1; adenylate cyclase 1 [EC:4.6.1.1]"]
["ENSRNOG00000065528",6,0.504811612,1,0.064330438,7.84716576,2.972171675,0.022010268,0.012738363,"up","yes","St8sia2","protein_coding","chr1:127762573-127838091:-","gi|16924022|ref|NP_476497.1|",1921,0,"alpha-2,8-sialyltransferase 8B precursor [Rattus norvegicus]","gi|164698488|ref|NM_009181.2|",3969,0,"Mus musculus ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 (St8sia2), mRNA","Q07977",744,0,"Alpha-2,8-sialyltransferase 8B",".",".",".",".","pfam00777","Glyco_transf_29","Glycosyltransferase family 29 (sialyltransferase). Members of this family belong to glycosyltransferase family 29.",".",".",".",".","."]
["ENSRNOG00000068310",6,0.504811612,1,0.064330438,7.84716576,2.972171675,0.022010268,0.012738363,"up","yes","C10H5orf58","protein_coding","chr10:18688847-18697220:-","gi|880891516|ref|XP_012970197.1|",306,{"v":1e-32,"d":"1.00E-32"},"PREDICTED: putative uncharacterized protein C5orf58 homolog [Mesocricetus auratus]","gi|589932315|ref|XR_442794.1|",175,{"v":8e-85,"d":"8.00E-85"},"PREDICTED: Peromyscus maniculatus bairdii uncharacterized LOC102918264 (LOC102918264), ncRNA",".",".",".",".",".",".",".",".","pfam04426","Bul1_C","Bul1 C terminus. This family contains the C terminus of Saccharomyces cerevisiae Bul1. Bul1 binds the ubiquitin ligase Rsp5, via an N terminal PPSY motif. The complex containing Bul1 and Rsp5 is involved in intracellular trafficking of the general amino acid permease Gap1, degradation of Rog1 in cooperation with Bul2 and GSK-3, and mitochondrial inheritance. Bul1 may contain HEAT repeats.",".",".",".",".","."]
["ENSRNOG00000070180",6,0.504811612,1,0.064330438,7.84716576,2.972171675,0.022010268,0.012738363,"up","yes","Prkag1","protein_coding","chr7:129963105-129980561:-","gi|6981392|ref|NP_037142.1|",1657,0,"5'-AMP-activated protein kinase subunit gamma-1 [Rattus norvegicus]","gi|672059834|ref|XM_006257331.2|",1516,0,"PREDICTED: Rattus norvegicus protein kinase, AMP-activated, gamma 1 non-catalytic subunit (Prkag1), transcript variant X1, mRNA","P80385",642,0,"5'-AMP-activated protein kinase subunit gamma-1","YGL115w",189,{"v":4e-54,"d":"4.00E-54"},"COG0517","pfam00571","CBS","CBS domain. CBS domains are small intracellular modules that pair together to form a stable globular domain. This family represents a single CBS domain. Pairs of these domains have been termed a Bateman domain. CBS domains have been shown to bind ligands with an adenosyl group such as AMP, ATP and S-AdoMet. CBS domains are found attached to a wide range of other protein domains suggesting that CBS domains may play a regulatory role making proteins sensitive to adenosyl carrying ligands. The region containing the CBS domains in Cystathionine-beta synthase is involved in regulation by S-AdoMet. CBS domain pairs from AMPK bind AMP or ATP. The CBS domains from IMPDH and the chloride channel CLC2 bind ATP.",".",".",".",".","."]
["ENSRNOG00000071073",6,0.504811612,1,0.064330438,7.84716576,2.972171675,0.022010268,0.012738363,"up","yes","Sost","protein_coding","chr10:86911517-86915561:-","gi|13399334|ref|NP_085073.1|",1027,{"v":3E-134,"d":"3.00E-134"},"sclerostin precursor [Rattus norvegicus]","gi|567316044|ref|NM_024449.6|",936,0,"Mus musculus sclerostin (Sost), mRNA","Q99P67",400,{"v":1E-135,"d":"1.00E-135"},"Sclerostin",".",".",".",".","pfam05463","Sclerostin","Sclerostin (SOST). This family contains several mammalian sclerostin (SOST) proteins. SOST is thought to suppress bone formation. Mutations of the SOST gene lead to sclerosteosis, a progressive sclerosing bone dysplasia with an autosomal recessive mode of inheritance. Radiologically, it is characterized by a generalised hyperostosis and sclerosis leading to a markedly thickened and sclerotic skull, with mandible, ribs, clavicles and all long bones also being affected. Due to narrowing of the foramina of the cranial nerves, facial nerve palsy, hearing loss and atrophy of the optic nerves can occur. Sclerosteosis is clinically and radiologically very similar to van Buchem disease, mainly differentiated by hand malformations and a large stature in sclerosteosis patients.",".",".",".",".","."]
["ENSRNOG00000013745",25,2.103381716,16,1.029287011,2.04353275,1.031065364,0.023196311,0.01336936,"up","yes","Ctrc","protein_coding","chr5:154147316-154156528:-","gi|117647210|ref|NP_001071117.1|",1380,0,"chymotrypsin-C precursor [Rattus norvegicus]","gi|402743729|ref|NM_001077649.2|",824,0,"Rattus norvegicus chymotrypsin C (Ctrc), mRNA","P55091",536,0,"Chymotrypsin-C","VC1649",104,{"v":5e-24,"d":"5.00E-24"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;GO:0006874|cellular calcium ion homeostasis;",".","GO:0004252|serine-type endopeptidase activity;GO:0008233|peptidase activity;","K01311","CTRC; chymotrypsin C [EC:3.4.21.2]"]
["ENSRNOG00000067786",25,2.103381716,16,1.029287011,2.04353275,1.031065364,0.023196311,0.01336936,"up","yes","ENSRNOG00000067786","protein_coding","chrX:59763210-59765903:-","gi|532115188|ref|XP_005342256.1|",2978,0,"PREDICTED: zinc finger X-linked protein ZXDB-like [Ictidomys tridecemlineatus]","gi|672087761|ref|XM_006257042.2|",1772,0,"PREDICTED: Rattus norvegicus zinc finger, X-linked, duplicated B (Zxdb), transcript variant X2, mRNA","P98169",1064,0,"Zinc finger X-linked protein ZXDB","SPAC144.09c",117,{"v":3e-27,"d":"3.00E-27"},"COG5048","pfam13465","zf-H2C2_2","Zinc-finger double domain.",".",".",".",".","."]
["ENSRNOG00000011986",12,1.009623224,5,0.321652191,3.138866304,1.650243581,0.023744651,0.013660816,"up","yes","Krt12","protein_coding","chr10:84370883-84378045:-","gi|564374308|ref|XP_006247419.1|",2025,0,"PREDICTED: keratin, type I cytoskeletal 12 isoform X1 [Rattus norvegicus]","gi|672068810|ref|XM_006247357.2|",1713,0,"PREDICTED: Rattus norvegicus keratin 12 (Krt12), transcript variant X1, mRNA","Q6IFW5",712,0,"Keratin, type I cytoskeletal 12",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0002009|morphogenesis of an epithelium;GO:0008150|biological_process;GO:0060429|epithelium development;GO:0061303|cornea development in camera-type eye;","GO:0005575|cellular_component;GO:0005882|intermediate filament;","GO:0003674|molecular_function;GO:0005198|structural molecule activity;","K07604","KRT1; type I keratin, acidic"]
["ENSRNOG00000020263",12,1.009623224,5,0.321652191,3.138866304,1.650243581,0.023744651,0.013660816,"up","yes","Atp1a3","protein_coding","chr1:80572796-80601918:-","gi|755519440|ref|XP_011248822.1|",5263,0,"PREDICTED: sodium/potassium-transporting ATPase subunit alpha-3 isoform X3 [Mus musculus]","gi|672034923|ref|XM_008758888.1|",3450,0,"PREDICTED: Rattus norvegicus ATPase, Na+/K+ transporting, alpha 3 polypeptide (Atp1a3), transcript variant X1, mRNA","P06687",2006,0,"Sodium/potassium-transporting ATPase subunit alpha-3","MA4378",648,0,"COG0474","pfam00122","E1-E2_ATPase","E1-E2 ATPase.","GO:0006813|potassium ion transport;GO:0006814|sodium ion transport;GO:0006883|cellular sodium ion homeostasis;GO:0007613|memory;GO:0008344|adult locomotory behavior;GO:0008542|visual learning;GO:0009410|response to xenobiotic stimulus;GO:0010248|establishment or maintenance of transmembrane electrochemical gradient;GO:0021987|cerebral cortex development;GO:0030007|cellular potassium ion homeostasis;GO:0035235|ionotropic glutamate receptor signaling pathway;GO:0036376|sodium ion export across plasma membrane;GO:0060048|cardiac muscle contraction;GO:0071300|cellular response to retinoic acid;GO:0086036|regulation of cardiac muscle cell membrane potential;GO:0097067|cellular response to thyroid hormone stimulus;GO:1902600|proton transmembrane transport;GO:1904646|cellular response to amyloid-beta;GO:1990535|neuron projection maintenance;GO:1990573|potassium ion import across plasma membrane;","GO:0001917|photoreceptor inner segment;GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005886|plasma membrane;GO:0005890|sodium:potassium-exchanging ATPase complex;GO:0016020|membrane;GO:0030424|axon;GO:0031090|organelle membrane;GO:0042383|sarcolemma;GO:0043025|neuronal cell body;GO:0043209|myelin sheath;GO:0044305|calyx of Held;GO:0044326|dendritic spine neck;GO:0044327|dendritic spine head;GO:0045202|synapse;GO:0098794|postsynapse;GO:0098984|neuron to neuron synapse;GO:0099056|integral component of presynaptic membrane;","GO:0001540|amyloid-beta binding;GO:0005391|sodium:potassium-exchanging ATPase activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0031748|D1 dopamine receptor binding;GO:0043395|heparan sulfate proteoglycan binding;GO:0046872|metal ion binding;GO:0051087|chaperone binding;GO:0086037|sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential;GO:0099520|ion antiporter activity involved in regulation of presynaptic membrane potential;","K01539","ATP1A; sodium/potassium-transporting ATPase subunit alpha [EC:7.2.2.13]"]
["ENSRNOG00000025349",12,1.009623224,5,0.321652191,3.138866304,1.650243581,0.023744651,0.013660816,"up","yes","Maneal","protein_coding","chr5:137115632-137122353:-","gi|109477207|ref|XP_001056614.1|",2124,0,"PREDICTED: glycoprotein endo-alpha-1,2-mannosidase-like protein isoform X1 [Rattus norvegicus]","gi|672019918|ref|XM_001056614.4|",2454,0,"PREDICTED: Rattus norvegicus mannosidase, endo-alpha-like (Maneal), transcript variant X1, mRNA","Q6P1J0",813,0,"Glycoprotein endo-alpha-1,2-mannosidase-like protein",".",".",".",".","pfam14307","Glyco_tran_WbsX","Glycosyltransferase WbsX. Members of this family are found in within O-antigen biosynthesis clusters in Gram negative bacteria, where they are predicted to function as glycosyltransferases.",".",".",".",".","."]
["ENSRNOG00000026974",12,1.009623224,5,0.321652191,3.138866304,1.650243581,0.023744651,0.013660816,"up","yes","Dbndd1","protein_coding","chr19:51539148-51548444:-","gi|81883079|sp|Q5M831.1|DBND1_RAT",766,{"v":6e-94,"d":"6.00E-94"},"RecName: Full=Dysbindin domain-containing protein 1","gi|62079046|ref|NM_001014156.1|",1454,0,"Rattus norvegicus dysbindin (dystrobrevin binding protein 1) domain containing 1 (Dbndd1), mRNA","Q5M831",299,{"v":2E-95,"d":"2.00E-95"},"Dysbindin domain-containing protein 1",".",".",".",".","pfam04440","Dysbindin","Dysbindin (Dystrobrevin binding protein 1). Dysbindin is an evolutionary conserved 40-kDa coiled-coil-containing protein that binds to alpha- and beta-dystrobrevin in muscle and brain. Dystrophin and alpha-dystrobrevin are co-immunoprecipitated with dysbindin, indicating that dysbindin is DPC-associated in muscle. Dysbindin co-localizes with alpha-dystrobrevin at the sarcolemma and is up-regulated in dystrophin-deficient muscle. In the brain, dysbindin is found primarily in axon bundles and especially in certain axon terminals, notably mossy fibre synaptic terminals in the cerebellum and hippocampus. Dysbindin may have implications for the molecular pathology of Duchenne muscular dystrophy and may provide an alternative route for anchoring dystrobrevin and the DPC to the muscle membrane. Genetic variation in the human dysbindin gene is also thought to be associated with Schizophrenia.","GO:0006469|negative regulation of protein kinase activity;","GO:0005737|cytoplasm;",".",".","."]
["ENSRNOG00000027697",12,1.009623224,5,0.321652191,3.138866304,1.650243581,0.023744651,0.013660816,"up","yes","Nmnat2","protein_coding","chr13:65105950-65278484:+","gi|37359974|dbj|BAC97965.1|",1421,0,"mKIAA0479 protein [Mus musculus]","gi|114158657|ref|NM_001048042.1|",853,0,"Rattus norvegicus nicotinamide nucleotide adenylyltransferase 2 (Nmnat2), mRNA","Q0HA29",504,{"v":4E-176,"d":"4.00E-176"},"Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2","YLR328w_2",100,{"v":5e-23,"d":"5.00E-23"},"COG1057","pfam01467","CTP_transf_2","Cytidylyltransferase. This family includes: Cholinephosphate cytidylyltransferase and Glycerol-3-phosphate cytidylyltransferase.","GO:0007568|aging;GO:0009435|NAD biosynthetic process;GO:1904385|cellular response to angiotensin;","GO:0000139|Golgi membrane;GO:0005737|cytoplasm;GO:0005770|late endosome;GO:0005794|Golgi apparatus;GO:0005802|trans-Golgi network;GO:0005829|cytosol;GO:0030424|axon;GO:0030659|cytoplasmic vesicle membrane;GO:0045202|synapse;","GO:0000309|nicotinamide-nucleotide adenylyltransferase activity;GO:0003674|molecular_function;GO:0004515|nicotinate-nucleotide adenylyltransferase activity;GO:0005524|ATP binding;","K06210","NMNAT; nicotinamide mononucleotide adenylyltransferase [EC:2.7.7.1 2.7.7.18]"]
["ENSRNOG00000038957",12,1.009623224,5,0.321652191,3.138866304,1.650243581,0.023744651,0.013660816,"up","yes","RGD1305184","protein_coding","chr18:53851449-53852696:+","gi|293354966|ref|XP_225905.4|",2123,0,"PREDICTED: interferon-inducible GTPase 1 [Rattus norvegicus]","gi|672030730|ref|XM_006222579.2|",1248,0,"PREDICTED: Rattus norvegicus similar to CDNA sequence BC023105 (RGD1305184), mRNA","Q9QZ85",426,{"v":3e-145,"d":"3.00E-145"},"Interferon-inducible GTPase 1",".",".",".",".","pfam05049","IIGP","Interferon-inducible GTPase (IIGP). Interferon-inducible GTPase (IIGP) is thought to play a role in in intracellular defence. IIGP is predominantly associated with the Golgi apparatus and also localizes to the endoplasmic reticulum and exerts a distinct role in IFN-induced intracellular membrane trafficking or processing.","GO:0006952|defense response;GO:0035458|cellular response to interferon-beta;","GO:0005789|endoplasmic reticulum membrane;","GO:0003924|GTPase activity;GO:0005525|GTP binding;",".","."]
["ENSRNOG00000047114",12,1.009623224,5,0.321652191,3.138866304,1.650243581,0.023744651,0.013660816,"up","yes","Cct8l1","protein_coding","chr4:9605000-9607208:-","gi|83642818|ref|NP_001032883.1|",2882,0,"chaperonin containing TCP1, subunit 8 (theta)-like 1 [Rattus norvegicus]","gi|672048710|ref|XM_006235969.2|",2083,0,"PREDICTED: Rattus norvegicus putative T-complex protein 1 subunit theta-like 2-like (LOC102553845), transcript variant X3, mRNA","Q96SF2",649,0,"T-complex protein 1 subunit theta-like 2",".",".",".",".","pfam00118","Cpn60_TCP1","TCP-1/cpn60 chaperonin family. This family includes members from the HSP60 chaperone family and the TCP-1 (T-complex protein) family.",".",".",".",".","."]
["ENSRNOG00000020380",17,1.430299567,9,0.578973944,2.470404036,1.304747015,0.023869466,0.013726824,"up","yes","Lgals7","protein_coding","chr1:84150252-84152015:+","gi|158517925|ref|NP_072104.2|",711,{"v":6e-92,"d":"6.00E-92"},"galectin-7 [Rattus norvegicus]","gi|672035697|ref|XM_006228670.2|",499,0,"PREDICTED: Rattus norvegicus lectin, galactoside-binding, soluble, 7 (Lgals7), transcript variant X2, mRNA","P97590",278,{"v":2e-93,"d":"2.00E-93"},"Galectin-7",".",".",".",".","pfam00337","Gal-bind_lectin","Galactoside-binding lectin. This family contains galactoside binding lectins.   The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).","GO:0006915|apoptotic process;GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0010628|positive regulation of gene expression;GO:0032689|negative regulation of interferon-gamma production;GO:2000562|negative regulation of CD4-positive, alpha-beta T cell proliferation;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005829|cytosol;","GO:0016936|galactoside binding;GO:0030246|carbohydrate binding;","K10092","LGALS7; galectin-7"]
["ENSRNOG00000070886",18,1.514434836,10,0.643304382,2.354149728,1.235206081,0.025913896,0.014810242,"up","yes","ENSRNOG00000070886","lncRNA","chr1:84971839-84972955:+","gi|532099919|ref|XP_005335591.1|",318,{"v":3e-66,"d":"3.00E-66"},"PREDICTED: ubiquitin-conjugating enzyme E2 N-like [Ictidomys tridecemlineatus]","gi|672013323|ref|XR_342836.2|",1105,0,"PREDICTED: Rattus norvegicus ubiquitin-conjugating enzyme E2 N-like (LOC100909892), transcript variant X1, misc_RNA","Q9EQX9",143,{"v":3e-63,"d":"3.00E-63"},"Ubiquitin-conjugating enzyme E2 N","YDR092w",100,{"v":2e-24,"d":"2.00E-24"},"COG5078","pfam00179","UQ_con","Ubiquitin-conjugating enzyme. Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. TSG101 is one of several UBC homologues that lacks this active site cysteine.",".",".",".",".","."]
["ENSRNOG00000000516",9,0.757217418,3,0.192991315,3.92358288,1.972171675,0.026875092,0.015287373,"up","yes","Pxt1","protein_coding","chr20:7002271-7006780:-","gi|672031741|ref|XP_008773177.1|",390,{"v":8e-44,"d":"8.00E-44"},"PREDICTED: peroxisomal testis-specific protein 1 [Rattus norvegicus]","gi|672085909|ref|XM_008772792.1|",558,0,"PREDICTED: Rattus norvegicus peroxisomal, testis specific 1 (Pxt1), transcript variant X2, mRNA","Q8K459",91.7,{"v":5e-22,"d":"5.00E-22"},"Peroxisomal testis-specific protein 1",".",".",".",".","pfam15214","PXT1","Peroxisomal testis-specific protein 1. This family of proteins is testis-specific.",".",".",".",".","."]
["ENSRNOG00000006631",9,0.757217418,3,0.192991315,3.92358288,1.972171675,0.026875092,0.015287373,"up","yes","Sema3e","protein_coding","chr4:20299718-20555229:-","gi|209862829|ref|NP_001100049.1|",4016,0,"semaphorin-3E precursor [Rattus norvegicus]","gi|209862828|ref|NM_001106579.1|",4476,0,"Rattus norvegicus semaphorin 3E (Sema3e), mRNA","P70275",1527,0,"Semaphorin-3E",".",".",".",".","pfam01403","Sema","Sema domain. The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and human plexin A-3.","GO:0001569|branching involved in blood vessel morphogenesis;GO:0001755|neural crest cell migration;GO:0001953|negative regulation of cell-matrix adhesion;GO:0002040|sprouting angiogenesis;GO:0007411|axon guidance;GO:0008360|regulation of cell shape;GO:0016525|negative regulation of angiogenesis;GO:0030335|positive regulation of cell migration;GO:0048843|negative regulation of axon extension involved in axon guidance;GO:0050808|synapse organization;GO:0050919|negative chemotaxis;GO:0071526|semaphorin-plexin signaling pathway;GO:2000249|regulation of actin cytoskeleton reorganization;","GO:0005615|extracellular space;GO:0005887|integral component of plasma membrane;","GO:0030215|semaphorin receptor binding;GO:0045499|chemorepellent activity;","K06840","SEMA3; semaphorin 3"]
["ENSRNOG00000012648",9,0.757217418,3,0.192991315,3.92358288,1.972171675,0.026875092,0.015287373,"up","yes","Ppp1r14d","protein_coding","chr3:106205046-106219649:-","gi|25282425|ref|NP_742008.1|",557,{"v":1e-68,"d":"1.00E-68"},"protein phosphatase 1 regulatory subunit 14D [Rattus norvegicus]","gi|25282424|ref|NM_172011.1|",727,0,"Rattus norvegicus protein phosphatase 1, regulatory (inhibitor) subunit 14D (Ppp1r14d), mRNA","Q8K3F4",219,{"v":4E-70,"d":"4.00E-70"},"Protein phosphatase 1 regulatory subunit 14D",".",".",".",".","pfam05361","PP1_inhibitor","PKC-activated protein phosphatase-1 inhibitor. Contractility of vascular smooth muscle depends on phosphorylation of myosin light chains, and is modulated by hormonal control of myosin phosphatase activity. Signaling pathways activate kinases such as PKC or Rho-dependent kinases that phosphorylate the myosin phosphatase inhibitor protein called CPI-17. Phosphorylation of CPI-17 at Thr-38 enhances its inhibitory potency 1000-fold, creating a molecular switch for regulating contraction.","GO:0042325|regulation of phosphorylation;GO:0043086|negative regulation of catalytic activity;GO:1905183|negative regulation of protein serine/threonine phosphatase activity;GO:1905184|positive regulation of protein serine/threonine phosphatase activity;","GO:0005737|cytoplasm;","GO:0004864|protein phosphatase inhibitor activity;GO:0004865|protein serine/threonine phosphatase inhibitor activity;","K17557","PPP1R14D, GBPI; protein phosphatase 1 regulatory subunit 14D"]
["ENSRNOG00000020733",9,0.757217418,3,0.192991315,3.92358288,1.972171675,0.026875092,0.015287373,"up","yes","Camp","protein_coding","chr8:109841729-109843543:-","gi|158262001|ref|NP_001094194.1|",799,{"v":8e-106,"d":"8.00E-106"},"cathelicidin antimicrobial peptide precursor [Rattus norvegicus]","gi|158262000|ref|NM_001100724.1|",586,0,"Rattus norvegicus cathelicidin antimicrobial peptide (Camp), mRNA","P51437",259,{"v":1e-86,"d":"1.00E-86"},"Cathelicidin antimicrobial peptide",".",".",".",".","pfam00666","Cathelicidins","Cathelicidin. A novel protein family, showing a conserved proregion and a variable carboxyl-terminal antimicrobial domain. This region shows similarity to cystatins.","GO:0001878|response to yeast;GO:0001934|positive regulation of protein phosphorylation;GO:0002227|innate immune response in mucosa;GO:0002544|chronic inflammatory response;GO:0008284|positive regulation of cell proliferation;GO:0019731|antibacterial humoral response;GO:0019732|antifungal humoral response;GO:0032757|positive regulation of interleukin-8 production;GO:0035821|modification of morphology or physiology of other organism;GO:0042742|defense response to bacterium;GO:0045087|innate immune response;GO:0045766|positive regulation of angiogenesis;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:0051838|cytolysis by host of symbiont cells;GO:0051873|killing by host of symbiont cells;GO:0061844|antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0071222|cellular response to lipopolysaccharide;GO:0071224|cellular response to peptidoglycan;GO:0071347|cellular response to interleukin-1;GO:0071354|cellular response to interleukin-6;GO:0071356|cellular response to tumor necrosis factor;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0042581|specific granule;GO:0042995|cell projection;","GO:0001530|lipopolysaccharide binding;GO:0003674|molecular_function;","K13916","CAMP, LL37; cathelicidin antimicrobial peptide"]
["ENSRNOG00000026503",9,0.757217418,3,0.192991315,3.92358288,1.972171675,0.026875092,0.015287373,"up","yes","Xrra1","protein_coding","chr1:154183377-154247895:+","gi|392337832|ref|XP_003753370.1|",4111,0,"PREDICTED: X-ray radiation resistance-associated protein 1 isoform X1 [Rattus norvegicus]","gi|672014077|ref|XM_003753322.3|",2757,0,"PREDICTED: Rattus norvegicus X-ray radiation resistance associated 1 (Xrra1), transcript variant X1, mRNA","Q3U3V8",1497,0,"X-ray radiation resistance-associated protein 1",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.","GO:0010165|response to X-ray;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0016604|nuclear body;",".",".","."]
["ENSRNOG00000064594",9,0.757217418,3,0.192991315,3.92358288,1.972171675,0.026875092,0.015287373,"up","yes","ENSRNOG00000064594","lncRNA","chr1:73396792-73402846:-","gi|344253875|gb|EGW09979.1|",119,{"v":3e-06,"d":"3.00E-06"},"hypothetical protein I79_016032 [Cricetulus griseus]","gi|300794531|ref|NM_001191693.1|",177,{"v":6e-86,"d":"6.00E-86"},"Rattus norvegicus Rho GTPase activating protein 21 (Arhgap21), mRNA",".",".",".",".",".",".",".",".","pfam01797","Y1_Tnp","Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from Escherichia coli.",".",".",".",".","."]
["ENSRNOG00000065219",9,0.757217418,3,0.192991315,3.92358288,1.972171675,0.026875092,0.015287373,"up","yes","ENSRNOG00000065219","protein_coding","chr20:2704465-2705186:+","gi|148692636|gb|EDL24583.1|",141,{"v":9e-10,"d":"9.00E-10"},"mCG130546, isoform CRA_b, partial [Mus musculus]","gi|672085499|ref|XR_361987.2|",223,{"v":9e-112,"d":"9.00E-112"},"PREDICTED: Rattus norvegicus uncharacterized LOC102549760 (LOC102549760), transcript variant X2, ncRNA",".",".",".",".",".",".",".",".","pfam00940","RNA_pol","DNA-dependent RNA polymerase. This is a family of single chain RNA polymerases.",".",".",".",".","."]
["ENSRNOG00000019789",19,1.598570104,11,0.70763482,2.259032567,1.17570507,0.027744979,0.015705077,"up","yes","Tssk4","protein_coding","chr15:29141792-29144128:+","gi|404441531|ref|NP_001258254.1|",1471,0,"testis-specific serine/threonine-protein kinase 4 [Rattus norvegicus]","gi|404441530|ref|NM_001271325.1|",1376,0,"Rattus norvegicus testis-specific serine kinase 4 (Tssk4), transcript variant 1, mRNA","Q9D411",513,{"v":1E-179,"d":"1.00E-179"},"Testis-specific serine/threonine-protein kinase 4",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006468|protein phosphorylation;GO:0007286|spermatid development;GO:0009566|fertilization;GO:0018105|peptidyl-serine phosphorylation;GO:0030317|flagellated sperm motility;GO:0032793|positive regulation of CREB transcription factor activity;GO:0035556|intracellular signal transduction;GO:1990443|peptidyl-threonine autophosphorylation;","GO:0031514|motile cilium;GO:0036126|sperm flagellum;","GO:0000287|magnesium ion binding;GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0005524|ATP binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0044877|protein-containing complex binding;","K08811","TSSK, STK22; testis-specific serine kinase [EC:2.7.11.1]"]
["ENSRNOG00000026176",19,1.598570104,11,0.70763482,2.259032567,1.17570507,0.027744979,0.015705077,"up","yes","Efcab12","protein_coding","chr4:148869387-148890560:-","gi|392340105|ref|XP_003753988.1|",3388,0,"PREDICTED: EF-hand calcium-binding domain-containing protein 12 isoform X2 [Rattus norvegicus]","gi|672018659|ref|XM_003753940.3|",2324,0,"PREDICTED: Rattus norvegicus EF-hand calcium binding domain 12 (Efcab12), transcript variant X2, mRNA","Q95LL8",616,0,"EF-hand calcium-binding domain-containing protein 12",".",".",".",".","pfam13405","EF-hand_6","EF-hand domain.",".",".","GO:0005509|calcium ion binding;",".","."]
["ENSRNOG00000029315",19,1.598570104,11,0.70763482,2.259032567,1.17570507,0.027744979,0.015705077,"up","yes","AC099294.1","protein_coding","chr1:205625668-205627920:+","gi|293340888|ref|XP_002724775.1|",3955,0,"PREDICTED: sentrin-specific protease 5 isoform X2 [Rattus norvegicus]","gi|672026153|ref|XM_002724729.4|",2214,0,"PREDICTED: Rattus norvegicus SUMO1/sentrin specific peptidase 5 (Senp5), transcript variant X3, mRNA","Q6NXL6",1416,0,"Sentrin-specific protease 5","SPBC19G7.09",127,{"v":9e-30,"d":"9.00E-30"},"COG5160","pfam02902","Peptidase_C48","Ulp1 protease family, C-terminal catalytic domain. This domain contains the catalytic triad Cys-His-Asn.",".","GO:0005730|nucleolus;","GO:0019783|ubiquitin-like protein-specific protease activity;",".","."]
["ENSRNOG00000031065",19,1.598570104,11,0.70763482,2.259032567,1.17570507,0.027744979,0.015705077,"up","yes","RT1-M1-2","protein_coding","chr20:1910656-1917936:-","gi|57012410|ref|NP_001008849.1|",1659,0,"RT1 class I, locus M1, gene 2 precursor [Rattus norvegicus]","gi|672085546|ref|XM_006255884.2|",1448,0,"PREDICTED: Rattus norvegicus RT1 class I, locus M1, gene 2 (RT1-M1-2), transcript variant X1, mRNA","P30375",331,{"v":1e-106,"d":"1.00E-106"},"Class I histocompatibility antigen, Gogo-A*0101 alpha chain",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.",".",".",".","K06751","MHC1; MHC class I antigen"]
["ENSRNOG00000009563",13,1.093758492,6,0.385982629,2.833698747,1.502686392,0.027904283,0.015782125,"up","yes","Krt2","protein_coding","chr7:132940862-132947963:-","gi|57114290|ref|NP_001008899.1|",1830,0,"keratin, type II cytoskeletal 2 epidermal [Rattus norvegicus]","gi|672060223|ref|XM_006242436.2|",2460,0,"PREDICTED: Rattus norvegicus keratin 2 (Krt2), transcript variant X1, mRNA","Q6IG02",709,0,"Keratin, type II cytoskeletal 2 epidermal",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0003334|keratinocyte development;GO:0008150|biological_process;GO:0008544|epidermis development;GO:0018149|peptide cross-linking;GO:0031424|keratinization;GO:0032980|keratinocyte activation;GO:0043616|keratinocyte proliferation;GO:0045109|intermediate filament organization;GO:0045684|positive regulation of epidermis development;GO:0051546|keratinocyte migration;","GO:0001533|cornified envelope;GO:0005575|cellular_component;GO:0045095|keratin filament;","GO:0003674|molecular_function;GO:0008092|cytoskeletal protein binding;GO:0030280|structural constituent of epidermis;","K07605","KRT2; type II keratin, basic"]
["ENSRNOG00000019159",13,1.093758492,6,0.385982629,2.833698747,1.502686392,0.027904283,0.015782125,"up","yes","Jakmip2","protein_coding","chr18:35532552-35747775:-","gi|507645114|ref|XP_004631318.1|",3743,0,"PREDICTED: janus kinase and microtubule-interacting protein 2 isoform X1 [Octodon degus]","gi|880879046|ref|XM_005069166.2|",3057,0,"PREDICTED: Mesocricetus auratus janus kinase and microtubule interacting protein 2 (Jakmip2), transcript variant X1, mRNA","Q96AA8",1412,0,"Janus kinase and microtubule-interacting protein 2",".",".",".",".","pfam02463","SMC_N","RecF/RecN/SMC N terminal domain. This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics.   This family also includes the RecF and RecN proteins that are involved in DNA metabolizm and recombination.",".","GO:0005794|Golgi apparatus;","GO:0008017|microtubule binding;GO:0019900|kinase binding;","K24784","JAKMIP2; janus kinase and microtubule-interacting protein 2"]
["ENSRNOG00000022283",13,1.093758492,6,0.385982629,2.833698747,1.502686392,0.027904283,0.015782125,"up","yes","Lhfpl5","protein_coding","chr20:6632362-6642532:+","gi|62078543|ref|NP_001013928.1|",1160,{"v":8e-156,"d":"8.00E-156"},"tetraspan membrane protein of hair cell stereocilia [Rattus norvegicus]","gi|62078542|ref|NM_001013906.1|",1349,0,"Rattus norvegicus lipoma HMGIC fusion partner-like 5 (Lhfpl5), mRNA","Q5PPI7",451,{"v":3E-157,"d":"3.00E-157"},"LHFPL tetraspan subfamily member 5 protein",".",".",".",".","pfam10242","L_HGMIC_fpl","Lipoma HMGIC fusion partner-like protein. This is a group of proteins expressed from a series of genes referred to as Lipoma HGMIC fusion partner-like. The proteins carry four highly conserved transmembrane domains in this entry. In certain instances, eg in LHFPL5, mutations cause deafness in humans and hypospadias, and LHFPL1 is transcribed in six liver tumor cell lines.","GO:0006811|ion transport;GO:0007605|sensory perception of sound;GO:0050910|detection of mechanical stimulus involved in sensory perception of sound;GO:0050974|detection of mechanical stimulus involved in sensory perception;GO:0060088|auditory receptor cell stereocilium organization;","GO:0005886|plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0016324|apical plasma membrane;GO:0032421|stereocilium bundle;GO:0032426|stereocilium tip;",".","K23893","LHFPL; LHFPL tetraspan subfamily member protein"]
["ENSRNOG00000036645",13,1.093758492,6,0.385982629,2.833698747,1.502686392,0.027904283,0.015782125,"up","yes","Ifitm6","protein_coding","chr1:196117049-196118386:-","gi|149061536|gb|EDM11959.1|",641,{"v":6e-82,"d":"6.00E-82"},"rCG47837 [Rattus norvegicus]","gi|672014464|ref|XM_008774732.1|",629,0,"PREDICTED: Rattus norvegicus interferon induced transmembrane protein 6 (Ifitm6), transcript variant X6, mRNA","Q01628",116,{"v":7e-31,"d":"7.00E-31"},"Interferon-induced transmembrane protein 3",".",".",".",".","pfam04505","Dispanin","Interferon-induced transmembrane protein. This family includes the human leukocyte antigen CD225, which is an interferon inducible transmembrane protein, and is associated with interferon induced cell growth suppression.","GO:0034341|response to interferon-gamma;GO:0035455|response to interferon-alpha;GO:0035456|response to interferon-beta;GO:0045071|negative regulation of viral genome replication;GO:0046597|negative regulation of viral entry into host cell;GO:0051607|defense response to virus;GO:0060337|type I interferon signaling pathway;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;",".","K06566","IFITM; interferon induced transmembrane protein"]
["ENSRNOG00000056580",13,1.093758492,6,0.385982629,2.833698747,1.502686392,0.027904283,0.015782125,"up","yes","En1","protein_coding","chr13:31751545-31755943:+","gi|672073973|ref|XP_001056699.3|",1078,{"v":6e-140,"d":"6.00E-140"},"PREDICTED: LOW QUALITY PROTEIN: homeobox protein engrailed-1 isoform X2 [Rattus norvegicus]","gi|672073972|ref|XM_001056699.6|",1345,0,"PREDICTED: Rattus norvegicus engrailed homeobox 1 (En1), transcript variant X2, mRNA","P09065",414,{"v":2e-139,"d":"2.00E-139"},"Homeobox protein engrailed-1",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0000122|negative regulation of transcription by RNA polymerase II;GO:0008344|adult locomotory behavior;GO:0009953|dorsal/ventral pattern formation;GO:0009954|proximal/distal pattern formation;GO:0010468|regulation of gene expression;GO:0021549|cerebellum development;GO:0030182|neuron differentiation;GO:0030326|embryonic limb morphogenesis;GO:0030901|midbrain development;GO:0030902|hindbrain development;GO:0030917|midbrain-hindbrain boundary development;GO:0035115|embryonic forelimb morphogenesis;GO:0035176|social behavior;GO:0035264|multicellular organism growth;GO:0042220|response to cocaine;GO:0042756|drinking behavior;GO:0043473|pigmentation;GO:0043524|negative regulation of neuron apoptotic process;GO:0045944|positive regulation of transcription by RNA polymerase II;GO:0048666|neuron development;GO:0060173|limb development;GO:0061743|motor learning;GO:1901215|negative regulation of neuron death;GO:1990403|embryonic brain development;","GO:0005634|nucleus;GO:0016020|membrane;","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0001227|DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003674|molecular_function;GO:1990837|sequence-specific double-stranded DNA binding;","K09319","EN; homeobox protein engrailed"]
["ENSRNOG00000059741",13,1.093758492,6,0.385982629,2.833698747,1.502686392,0.027904283,0.015782125,"up","yes","Tmc4","protein_coding","chr1:65539721-65551677:+","gi|149029798|gb|EDL84930.1|",3456,0,"transmembrane channel-like gene family 4 [Rattus norvegicus]","gi|77681957|ref|NM_001034104.1|",2262,0,"Rattus norvegicus transmembrane channel-like 4 (Tmc4), mRNA","Q496Z4",1283,0,"Transmembrane channel-like protein 4",".",".",".",".","pfam07810","TMC","TMC domain. These sequences are similar to a region conserved amongst various protein products of the transmembrane channel-like (TMC) gene family, such as Transmembrane channel-like protein 3 and EVIN2 - this region is termed the TMC domain. Mutations in these genes are implicated in a number of human conditions, such as deafness and epidermodysplasia verruciformis. TMC proteins are thought to have important cellular roles, and may be modifiers of ion channels or transporters.","GO:0034220|ion transmembrane transport;","GO:0005887|integral component of plasma membrane;","GO:0008381|mechanosensitive ion channel activity;","K21988","TMC; transmembrane channel-like protein"]
["ENSRNOG00000061230",20,1.682705373,12,0.771965258,2.179768267,1.124174769,0.029372854,0.016504713,"up","yes","L1cam","protein_coding","chrX:151597277-151623857:-","gi|672088986|ref|XP_008771859.1|",6397,0,"PREDICTED: neural cell adhesion molecule L1 isoform X3 [Rattus norvegicus]","gi|672088985|ref|XM_008773637.1|",5069,0,"PREDICTED: Rattus norvegicus L1 cell adhesion molecule (L1cam), transcript variant X3, mRNA","Q05695",2441,0,"Neural cell adhesion molecule L1",".",".",".",".","pfam13882","Bravo_FIGEY","Bravo-like intracellular region. This is the very C-terminal intracellular region of neural adhesion molecule L1 proteins that are also known as Bravo or NrCAM. It lies upstream of the IG and Fn3 domains and has the highly conserved motif FIGEY. The function is not known.","GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007159|leukocyte cell-cell adhesion;GO:0007160|cell-matrix adhesion;GO:0007166|cell surface receptor signaling pathway;GO:0007411|axon guidance;GO:0007413|axonal fasciculation;GO:0010811|positive regulation of cell-substrate adhesion;GO:0014823|response to activity;GO:0016477|cell migration;GO:0022409|positive regulation of cell-cell adhesion;GO:0030182|neuron differentiation;GO:0031175|neuron projection development;GO:0033631|cell-cell adhesion mediated by integrin;GO:0034109|homotypic cell-cell adhesion;GO:0045773|positive regulation of axon extension;GO:0050804|modulation of chemical synaptic transmission;GO:0050808|synapse organization;GO:0050850|positive regulation of calcium-mediated signaling;GO:0061564|axon development;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:0071361|cellular response to ethanol;GO:0071542|dopaminergic neuron differentiation;GO:0071549|cellular response to dexamethasone stimulus;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0097066|response to thyroid hormone;GO:0097069|cellular response to thyroxine stimulus;GO:1990090|cellular response to nerve growth factor stimulus;","GO:0005768|endosome;GO:0005886|plasma membrane;GO:0009897|external side of plasma membrane;GO:0009986|cell surface;GO:0016020|membrane;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0030425|dendrite;GO:0042734|presynaptic membrane;GO:0043025|neuronal cell body;GO:0043195|terminal bouton;GO:0044294|dendritic growth cone;GO:0044295|axonal growth cone;GO:0045121|membrane raft;GO:0098685|Schaffer collateral - CA1 synapse;","GO:0005178|integrin binding;GO:0005515|protein binding;GO:0008046|axon guidance receptor activity;GO:0019904|protein domain specific binding;GO:0030165|PDZ domain binding;GO:0033691|sialic acid binding;GO:0042802|identical protein binding;GO:0043621|protein self-association;","K06550","L1CAM, CD171; L1 cell adhesion molecule"]
["ENSRNOG00000066031",20,1.682705373,12,0.771965258,2.179768267,1.124174769,0.029372854,0.016504713,"up","yes","ENSRNOG00000066031","lncRNA","chr8:5200351-5206759:-","gi|149018768|gb|EDL77409.1|",241,{"v":8e-21,"d":"8.00E-21"},"rCG25260 [Rattus norvegicus]","gi|672022497|ref|XM_006226297.2|",1168,0,"PREDICTED: Rattus norvegicus similar to mKIAA1377 protein (RGD1563556), transcript variant X4, mRNA",".",".",".",".",".",".",".",".","pfam13900","GVQW","Putative binding domain. This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.",".",".",".",".","."]
["ENSRNOG00000011973",21,1.766840642,13,0.836295696,2.112698474,1.079086879,0.030809848,0.017188,"up","yes","Il7","protein_coding","chr2:94234766-94280075:+","gi|625202283|ref|XP_007642782.1|",748,{"v":1E-89,"d":"1.00E-89"},"PREDICTED: interleukin-7 [Cricetulus griseus]","gi|298883913|emb|FQ226549.1|",2769,0,"Rattus norvegicus TL0AEA25YO03 mRNA sequence","P56478",287,{"v":2e-89,"d":"2.00E-89"},"Interleukin-7",".",".",".",".","pfam01415","IL7","Interleukin 7/9 family. IL-7 is a cytokine that acts as a growth factor for early lymphoid cells of both B- and T-cell lineages. IL-9 is a multi-functional cytokine that, although originally described as a T-cell growth factor, its function in T-cell response remains unclear.","GO:0001961|positive regulation of cytokine-mediated signaling pathway;GO:0002360|T cell lineage commitment;GO:0006955|immune response;GO:0010165|response to X-ray;GO:0010468|regulation of gene expression;GO:0010628|positive regulation of gene expression;GO:0019221|cytokine-mediated signaling pathway;GO:0030890|positive regulation of B cell proliferation;GO:0032722|positive regulation of chemokine production;GO:0043066|negative regulation of apoptotic process;GO:0043086|negative regulation of catalytic activity;GO:0045453|bone resorption;GO:0045579|positive regulation of B cell differentiation;GO:0045582|positive regulation of T cell differentiation;GO:0046622|positive regulation of organ growth;GO:0048873|homeostasis of number of cells within a tissue;GO:0050730|regulation of peptidyl-tyrosine phosphorylation;GO:0071456|cellular response to hypoxia;GO:2001237|negative regulation of extrinsic apoptotic signaling pathway;GO:2001240|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0003674|molecular_function;GO:0005125|cytokine activity;GO:0005139|interleukin-7 receptor binding;GO:0008083|growth factor activity;","K05431","IL7; interleukin 7"]
["ENSRNOG00000036856",21,1.766840642,13,0.836295696,2.112698474,1.079086879,0.030809848,0.017188,"up","yes","AC097183.1","protein_coding","chr5:166724984-166725751:+","gi|392340794|ref|XP_003754170.1|",962,{"v":3e-128,"d":"3.00E-128"},"PREDICTED: RING finger protein 223 [Rattus norvegicus]","gi|564354606|ref|XM_003750095.2|",768,0,"PREDICTED: Rattus norvegicus ring finger protein 223 (Rnf223), mRNA","Q3UV31",298,{"v":3e-99,"d":"3.00E-99"},"RING finger protein 223",".",".",".",".","pfam13639","zf-RING_2","Ring finger domain.",".",".",".",".","."]
["ENSRNOG00000050804",21,1.766840642,13,0.836295696,2.112698474,1.079086879,0.030809848,0.017188,"up","yes","Zfp353","protein_coding","chr5:105075075-105076667:-","gi|564351653|ref|XP_233185.6|",2865,0,"PREDICTED: uncharacterized protein Zfp353 [Rattus norvegicus]","gi|672053097|ref|XM_233185.7|",1593,0,"PREDICTED: Rattus norvegicus zinc finger protein 353 (Zfp353), mRNA","Q9EPW2",105,{"v":3E-23,"d":"3.00E-23"},"Krueppel-like factor 15",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0006357|regulation of transcription by RNA polymerase II;",".","GO:0000978|RNA polymerase II proximal promoter sequence-specific DNA binding;GO:0000981|DNA-binding transcription factor activity, RNA polymerase II-specific;",".","."]
["ENSRNOG00000009555",14,1.177893761,7,0.450313067,2.61572192,1.387209175,0.031645343,0.017617998,"up","yes","Lrriq3","protein_coding","chr2:244126200-244212339:+","gi|149026303|gb|EDL82546.1|",1581,0,"similar to RIKEN cDNA 4933403H06, isoform CRA_a [Rattus norvegicus]","gi|12854215|dbj|AK015758.1|",902,0,"Mus musculus adult male testis cDNA, RIKEN full-length enriched library, clone:4930511J15 product:hypothetical IQ calmodulin-binding motif/Protein splicing (intein)/Leucine-rich repeat containing protein, full insert sequence",".",".",".",".","lin0372",55.8,{"v":4e-07,"d":"4.00E-07"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.",".",".",".",".","."]
["ENSRNOG00000027035",14,1.177893761,7,0.450313067,2.61572192,1.387209175,0.031645343,0.017617998,"up","yes","Sgo2","protein_coding","chr9:59548683-59573229:+","gi|403225019|ref|NP_001258120.1|",5516,0,"shugoshin-like 2 [Rattus norvegicus]","gi|672065177|ref|XM_006244988.2|",3976,0,"PREDICTED: Rattus norvegicus shugoshin-like 2 (S. pombe) (Sgol2), transcript variant X1, mRNA","Q7TSY8",1556,0,"Shugoshin 2",".",".",".",".","pfam07558","Shugoshin_N","Shugoshin N-terminal coiled-coil region. The Shugoshin protein is found to have this conserved N-terminal coiled-coil region and a highly conserved C-terminal basic region, family Shugoshin_C pfam07557. Shugoshin is a crucial target of Bub1 kinase function at kinetochores, necessary for both meiotic and mitotic localisation of shugoshin to the kinetochore. Human shugoshin is diffusible and mediates kinetochore-driven formation of kinetochore-microtubules during bipolar spindle assembly. Further, the primary role of shugoshin is to ensure bipolar attachment of kinetochores, and its role in protecting cohesion has co-developed to facilitate this process.","GO:0000070|mitotic sister chromatid segregation;GO:0007140|male meiotic nuclear division;GO:0007143|female meiotic nuclear division;GO:0008104|protein localization;GO:0010789|meiotic sister chromatid cohesion involved in meiosis I;GO:0045143|homologous chromosome segregation;GO:0051177|meiotic sister chromatid cohesion;GO:0051301|cell division;GO:0051754|meiotic sister chromatid cohesion, centromeric;GO:2000711|positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric;","GO:0000775|chromosome, centromeric region;GO:0000776|kinetochore;GO:0000779|condensed chromosome, centromeric region;GO:0005654|nucleoplasm;GO:0016604|nuclear body;GO:0030892|mitotic cohesin complex;",".","K11581","SGOL2; shugoshin-like 2"]
["ENSRNOG00000061247",14,1.177893761,7,0.450313067,2.61572192,1.387209175,0.031645343,0.017617998,"up","yes","Deup1","protein_coding","chr8:12380302-12442199:-","gi|672060919|ref|XP_008764155.1|",3298,0,"PREDICTED: deuterosome protein 1 isoform X1 [Rattus norvegicus]","gi|672060920|ref|XM_008765934.1|",2718,0,"PREDICTED: Rattus norvegicus coiled-coil domain containing 67 (Ccdc67), transcript variant X2, mRNA","Q5U3Z6",1159,0,"Deuterosome assembly protein 1",".",".",".",".","pfam13868","Trichoplein","tumor suppressor, Mitostatin. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs).","GO:0007099|centriole replication;GO:0030030|cell projection organization;GO:0098535|de novo centriole assembly involved in multi-ciliated epithelial cell differentiation;GO:1903251|multi-ciliated epithelial cell differentiation;","GO:0005737|cytoplasm;GO:0005814|centriole;GO:0098536|deuterosome;","GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000006104",22,1.85097591,14,0.900626135,2.05521008,1.039285871,0.032069255,0.017836043,"up","yes","Tg","protein_coding","chr7:98418293-98603210:+","gi|398650654|ref|NP_112250.2|",14647,0,"thyroglobulin isoform 1 precursor [Rattus norvegicus]","gi|398650653|ref|NM_030988.2|",8461,0,"Rattus norvegicus thyroglobulin (Tg), transcript variant 1, mRNA","P06882",5637,0,"Thyroglobulin","BS_pnbA",165,{"v":2E-41,"d":"2.00E-41"},"COG2272","pfam00135","COesterase","Carboxylesterase family.","GO:0006590|thyroid hormone generation;GO:0007165|signal transduction;GO:0009268|response to pH;GO:0015705|iodide transport;GO:0030878|thyroid gland development;GO:0031641|regulation of myelination;GO:0032496|response to lipopolysaccharide;GO:0042403|thyroid hormone metabolic process;GO:0042446|hormone biosynthetic process;GO:0045056|transcytosis;","GO:0005615|extracellular space;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0032991|protein-containing complex;GO:0048471|perinuclear region of cytoplasm;","GO:0005102|signaling receptor binding;GO:0005179|hormone activity;GO:0005515|protein binding;GO:0042802|identical protein binding;GO:0043168|anion binding;GO:0044877|protein-containing complex binding;GO:0051087|chaperone binding;","K10809","TG; thyroglobulin"]
["ENSRNOG00000034087",22,1.85097591,14,0.900626135,2.05521008,1.039285871,0.032069255,0.017836043,"up","yes","Krt42","protein_coding","chr10:85185181-85192595:-","gi|57012446|ref|NP_001008816.1|",2224,0,"keratin, type I cytoskeletal 42 [Rattus norvegicus]","gi|57012445|ref|NM_001008816.1|",1359,0,"Rattus norvegicus keratin 42 (Krt42), mRNA","Q6IFU7",861,0,"Keratin, type I cytoskeletal 42",".",".",".",".","pfam00038","Filament","Intermediate filament protein.",".","GO:0005737|cytoplasm;GO:0005882|intermediate filament;","GO:0005198|structural molecule activity;","K07604","KRT1; type I keratin, acidic"]
["ENSRNOG00000024717",23,1.935111179,15,0.964956573,2.005386805,1.003880535,0.033164572,0.018399835,"up","yes","Espnl","protein_coding","chr9:91912049-91935292:+","gi|300796937|ref|NP_001178741.1|",4644,0,"espin-like protein [Rattus norvegicus]","gi|300796936|ref|NM_001191812.1|",3000,0,"Rattus norvegicus espin-like (Espnl), mRNA","Q3UYR4",1693,0,"Espin-like protein","all2748",93.6,{"v":3e-19,"d":"3.00E-19"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0007605|sensory perception of sound;GO:0051017|actin filament bundle assembly;","GO:0005737|cytoplasm;GO:0032426|stereocilium tip;","GO:0051015|actin filament binding;","K24047","ESPN; espin"]
["ENSRNOG00000032429",23,1.935111179,15,0.964956573,2.005386805,1.003880535,0.033164572,0.018399835,"up","yes","Tmprss9","protein_coding","chr7:8810320-8831177:-","gi|564358159|ref|XP_006240993.1|",5252,0,"PREDICTED: transmembrane protease serine 9 isoform X1 [Rattus norvegicus]","gi|564358158|ref|XM_006240931.1|",3455,0,"PREDICTED: Rattus norvegicus transmembrane protease, serine 9 (Tmprss9), transcript variant X1, mRNA","P69526",1943,0,"Transmembrane protease serine 9","VC1649",117,{"v":2e-26,"d":"2.00E-26"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;GO:0031639|plasminogen activation;","GO:0005887|integral component of plasma membrane;GO:0016020|membrane;","GO:0004252|serine-type endopeptidase activity;GO:0008236|serine-type peptidase activity;","K09640","TMPRSS9; transmembrane protease serine 9 [EC:3.4.21.-]"]
["ENSRNOG00000009135",10,0.841352686,4,0.257321753,3.2696524,1.70913727,0.034329779,0.018945911,"up","yes","ENSRNOG00000009135","protein_coding","chr4:30569045-30588558:-","gi|564303287|ref|XP_006224883.1|",1141,{"v":2e-151,"d":"2.00E-151"},"PREDICTED: EF-hand calcium-binding domain-containing protein 1-like [Rattus norvegicus]","gi|672017999|ref|XM_006224821.2|",1669,0,"PREDICTED: Rattus norvegicus similar to EF hand calcium binding domain 1 (LOC500007), mRNA","Q32L26",234,{"v":3e-71,"d":"3.00E-71"},"EF-hand calcium-binding domain-containing protein 1","YKL190w",77.8,{"v":1e-15,"d":"1.00E-15"},"COG5126","pfam13499","EF-hand_7","EF-hand domain pair.",".",".","GO:0005509|calcium ion binding;",".","."]
["ENSRNOG00000018780",10,0.841352686,4,0.257321753,3.2696524,1.70913727,0.034329779,0.018945911,"up","yes","Sh3rf2","protein_coding","chr18:34046879-34146856:+","gi|77736552|ref|NP_001029359.1|",3567,0,"putative E3 ubiquitin-protein ligase SH3RF2 [Rattus norvegicus]","gi|77736551|ref|NM_001034187.1|",2408,0,"Rattus norvegicus SH3 domain containing ring finger 2 (Sh3rf2), mRNA","Q498M5",1357,0,"Putative E3 ubiquitin-protein ligase SH3RF2",".",".",".",".","pfam00018","SH3_1","SH3 domain. SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta barrel.","GO:0030335|positive regulation of cell migration;GO:0031397|negative regulation of protein ubiquitination;GO:0032436|positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0043066|negative regulation of apoptotic process;GO:0043086|negative regulation of catalytic activity;GO:0046329|negative regulation of JNK cascade;GO:0046330|positive regulation of JNK cascade;GO:0051865|protein autoubiquitination;","GO:0005634|nucleus;GO:0005654|nucleoplasm;","GO:0004864|protein phosphatase inhibitor activity;GO:0005515|protein binding;GO:0008157|protein phosphatase 1 binding;GO:0019902|phosphatase binding;GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;","K12171","SH3RF, POSH; E3 ubiquitin-protein ligase SH3RF [EC:2.3.2.27]"]
["ENSRNOG00000018820",10,0.841352686,4,0.257321753,3.2696524,1.70913727,0.034329779,0.018945911,"up","yes","Plac8l1","protein_coding","chr18:34168864-34190800:-","gi|293343066|ref|XP_002725380.1|",915,{"v":2e-122,"d":"2.00E-122"},"PREDICTED: PLAC8-like protein 1 [Rattus norvegicus]","gi|672030626|ref|XM_002725334.4|",749,0,"PREDICTED: Rattus norvegicus PLAC8-like 1 (Plac8l1), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam04749","PLAC8","PLAC8 family. This family includes the Placenta-specific gene 8 protein.",".",".",".",".","."]
["ENSRNOG00000019267",10,0.841352686,4,0.257321753,3.2696524,1.70913727,0.034329779,0.018945911,"up","yes","Dkk4","protein_coding","chr16:69402989-69406580:-","gi|157818825|ref|NP_001102802.1|",1069,{"v":3e-141,"d":"3.00E-141"},"dickkopf-related protein 4 precursor [Rattus norvegicus]","gi|157818824|ref|NM_001109332.1|",1491,0,"Rattus norvegicus dickkopf WNT signaling pathway inhibitor 4 (Dkk4), mRNA","Q8VEJ3",385,{"v":1e-130,"d":"1.00E-130"},"Dickkopf-related protein 4",".",".",".",".","pfam04706","Dickkopf_N","Dickkopf N-terminal cysteine-rich region. Dickkopf proteins are a class of Wnt antagonists. They possess two conserved cysteine-rich regions. This family represents the N-terminal one. The C-terminal region has been found to share significant sequence similarity to the colipase fold, pfam01114, pfam02740.","GO:0016055|Wnt signaling pathway;GO:0061170|negative regulation of hair follicle placode formation;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:2000272|negative regulation of signaling receptor activity;","GO:0005615|extracellular space;","GO:0039706|co-receptor binding;GO:0048019|receptor antagonist activity;","K02165","DKK1_2_4; dickkopf 1/2/4"]
["ENSRNOG00000023566",10,0.841352686,4,0.257321753,3.2696524,1.70913727,0.034329779,0.018945911,"up","yes","Vwa3b","protein_coding","chr9:39250430-39419611:+","gi|672023915|ref|XP_008756232.1|",6407,0,"PREDICTED: von Willebrand factor A domain-containing protein 3B isoform X2 [Rattus norvegicus]","gi|672023914|ref|XM_008758010.1|",3937,0,"PREDICTED: Rattus norvegicus von Willebrand factor A domain containing 3B (Vwa3b), transcript variant X3, mRNA","Q502W6",1750,0,"von Willebrand factor A domain-containing protein 3B",".",".",".",".","pfam15057","DUF4537","Domain of unknown function (DUF4537). The function of this domain family is unknown. It is found in eukaryotes, and is typically between 119 and 141 amino acids in length. In humans, it is found in the chromosomal position C11orf16.",".","GO:0005654|nucleoplasm;GO:0005829|cytosol;",".","K24509","VWA3; von Willebrand factor A domain-containing protein 3"]
["ENSRNOG00000029082",10,0.841352686,4,0.257321753,3.2696524,1.70913727,0.034329779,0.018945911,"up","yes","AABR07005031.1","protein_coding","chr1:165377553-165378489:-","gi|1706910|sp|P49945.2|FRIL2_MOUSE",834,{"v":5e-109,"d":"5.00E-109"},"RecName: Full=Ferritin light chain 2; AltName: Full=Ferritin L subunit 2; AltName: Full=Ferritin subunit LG","gi|60592501|emb|BX511204.3|",937,0,"Rattus norvegicus chromosome 1 BAC RP32-187K23, complete sequence","P49945",325,{"v":2e-110,"d":"2.00E-110"},"Ferritin light chain 2",".",".",".",".","pfam00210","Ferritin","Ferritin-like domain. This family contains ferritins and other ferritin-like proteins such as members of the DPS family and bacterioferritins.","GO:0006826|iron ion transport;",".",".",".","."]
["ENSRNOG00000042162",10,0.841352686,4,0.257321753,3.2696524,1.70913727,0.034329779,0.018945911,"up","yes","Wfdc3","protein_coding","chr3:153464862-153478952:-","gi|157818321|ref|NP_001100011.1|",586,{"v":2e-72,"d":"2.00E-72"},"WAP four-disulfide core domain protein 3 precursor [Rattus norvegicus]","gi|157818320|ref|NM_001106541.1|",915,0,"Rattus norvegicus WAP four-disulfide core domain 3 (Wfdc3), mRNA","Q14AE4",211,{"v":1e-66,"d":"1.00E-66"},"WAP four-disulfide core domain protein 3",".",".",".",".","pfam00095","WAP","WAP-type (Whey Acidic Protein) 'four-disulfide core'.","GO:0010951|negative regulation of endopeptidase activity;GO:0019731|antibacterial humoral response;GO:0045087|innate immune response;","GO:0005615|extracellular space;","GO:0004867|serine-type endopeptidase inhibitor activity;","K23637","WFDC3; WAP four-disulfide core domain protein 3"]
["ENSRNOG00000070035",10,0.841352686,4,0.257321753,3.2696524,1.70913727,0.034329779,0.018945911,"up","yes","ENSRNOG00000070035","protein_coding","chrX:59701178-59703871:+","gi|532115188|ref|XP_005342256.1|",2978,0,"PREDICTED: zinc finger X-linked protein ZXDB-like [Ictidomys tridecemlineatus]","gi|672087761|ref|XM_006257042.2|",1772,0,"PREDICTED: Rattus norvegicus zinc finger, X-linked, duplicated B (Zxdb), transcript variant X2, mRNA","P98169",1064,0,"Zinc finger X-linked protein ZXDB","SPAC144.09c",117,{"v":3e-27,"d":"3.00E-27"},"COG5048","pfam13465","zf-H2C2_2","Zinc-finger double domain.",".",".",".",".","."]
["ENSRNOG00000004498",15,1.26202903,8,0.514643505,2.4522393,1.29409977,0.034966987,0.019248798,"up","yes","Scin","protein_coding","chr6:57109403-57188242:-","gi|38454236|ref|NP_942043.1|",3611,0,"adseverin [Rattus norvegicus]","gi|672056016|ref|XM_008764644.1|",2578,0,"PREDICTED: Rattus norvegicus scinderin (Scin), transcript variant X1, mRNA","Q60604",1369,0,"Adseverin",".",".",".",".","pfam00626","Gelsolin","Gelsolin repeat.","GO:0007417|central nervous system development;GO:0008154|actin polymerization or depolymerization;GO:0008285|negative regulation of cell proliferation;GO:0030031|cell projection assembly;GO:0042989|sequestering of actin monomers;GO:0043065|positive regulation of apoptotic process;GO:0045654|positive regulation of megakaryocyte differentiation;GO:0051014|actin filament severing;GO:0051016|barbed-end actin filament capping;GO:0051127|positive regulation of actin nucleation;GO:0051693|actin filament capping;","GO:0002102|podosome;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0005903|brush border;GO:0015629|actin cytoskeleton;GO:0030054|cell junction;GO:0032991|protein-containing complex;","GO:0005509|calcium ion binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0051015|actin filament binding;","K05768","GSN; gelsolin"]
["ENSRNOG00000007811",15,1.26202903,8,0.514643505,2.4522393,1.29409977,0.034966987,0.019248798,"up","yes","Klrb1c","protein_coding","chr4:162381602-162393786:+","gi|145966851|ref|NP_001078872.1|",1038,{"v":1e-140,"d":"1.00E-140"},"killer cell lectin-like receptor subfamily B member 1F [Rattus norvegicus]","gi|672051237|ref|XM_008763329.1|",738,0,"PREDICTED: Rattus norvegicus killer cell lectin-like receptor subfamily B member 1C (Klrb1c), transcript variant X1, mRNA","Q63378",404,{"v":4e-142,"d":"4.00E-142"},"Killer cell lectin-like receptor subfamily B member 1F",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type",".","GO:0016021|integral component of membrane;","GO:0030246|carbohydrate binding;","K06543","KLRB, CD161; killer cell lectin-like receptor subfamily B"]
["ENSRNOG00000007951",15,1.26202903,8,0.514643505,2.4522393,1.29409977,0.034966987,0.019248798,"up","yes","Galnt14","protein_coding","chr6:21755195-21972192:+","gi|564355061|ref|XP_006239837.1|",2769,0,"PREDICTED: polypeptide N-acetylgalactosaminyltransferase 14 isoform X1 [Rattus norvegicus]","gi|672055495|ref|XM_006239775.2|",2042,0,"PREDICTED: Rattus norvegicus polypeptide N-acetylgalactosaminyltransferase 14 (Galnt14), transcript variant X1, mRNA","Q8BVG5",1036,0,"Polypeptide N-acetylgalactosaminyltransferase 14",".",".",".",".","pfam00535","Glycos_transf_2","Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.","GO:0006486|protein glycosylation;","GO:0000139|Golgi membrane;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;","GO:0004653|polypeptide N-acetylgalactosaminyltransferase activity;GO:0030246|carbohydrate binding;GO:0046872|metal ion binding;","K00710","GALNT; polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41]"]
["ENSRNOG00000008034",15,1.26202903,8,0.514643505,2.4522393,1.29409977,0.034966987,0.019248798,"up","yes","Tmeff1","protein_coding","chr5:62910740-62996493:+","gi|148670383|gb|EDL02330.1|",1537,0,"transmembrane protein with EGF-like and two follistatin-like domains 1, isoform CRA_b, partial [Mus musculus]","gi|121583853|ref|NM_023020.2|",1347,0,"Rattus norvegicus transmembrane protein with EGF-like and two follistatin-like domains 1 (Tmeff1), mRNA","Q9QYV1",580,0,"Tomoregulin-1",".",".",".",".","pfam07648","Kazal_2","Kazal-type serine protease inhibitor domain. Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.","GO:0008045|motor neuron axon guidance;GO:0009887|animal organ morphogenesis;GO:0009888|tissue development;GO:0016358|dendrite development;","GO:0005604|basement membrane;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;","GO:0005102|signaling receptor binding;","K23607","TMEFF1; tomoregulin-1"]
["ENSRNOG00000020997",15,1.26202903,8,0.514643505,2.4522393,1.29409977,0.034966987,0.019248798,"up","yes","Ms4a4c","protein_coding","chr1:208124986-208146351:+","gi|157821819|ref|NP_001099809.1|",1120,{"v":2E-150,"d":"2.00E-150"},"membrane-spanning 4-domains, subfamily A, member 4C [Rattus norvegicus]","gi|672039830|ref|XM_006231087.2|",1150,0,"PREDICTED: Rattus norvegicus membrane-spanning 4-domains, subfamily A, member 4C (Ms4a4c), transcript variant X1, mRNA","Q99N05",299,{"v":2e-98,"d":"2.00E-98"},"Membrane-spanning 4-domains subfamily A member 4D",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.",".","GO:0016021|integral component of membrane;",".","K22190","MS4A3S; membrane-spanning 4-domains subfamily A member 3/4/8/12/15/18"]
["ENSRNOG00000047574",15,1.26202903,8,0.514643505,2.4522393,1.29409977,0.034966987,0.019248798,"up","yes","Nrxn3","protein_coding","chr6:107641780-109272044:+","gi|568978996|ref|XP_006515624.1|",7049,0,"PREDICTED: neurexin 3 isoform X19 [Mus musculus]","gi|568979001|ref|XR_381485.1|",6597,0,"PREDICTED: Mus musculus neurexin III (Nrxn3), transcript variant X32, misc_RNA","Q6P9K9",2672,0,"Neurexin-3",".",".",".",".","pfam02210","Laminin_G_2","Laminin G domain. This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.","GO:0007155|cell adhesion;GO:0007268|chemical synaptic transmission;GO:0007269|neurotransmitter secretion;GO:0007416|synapse assembly;GO:0007612|learning;GO:0008150|biological_process;GO:0030534|adult behavior;GO:0035176|social behavior;GO:0071625|vocalization behavior;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0032991|protein-containing complex;GO:0098793|presynapse;GO:0098982|GABA-ergic synapse;","GO:0003674|molecular_function;GO:0005246|calcium channel regulator activity;GO:0046872|metal ion binding;","K07377","NRXN; neurexin"]
["ENSRNOG00000048430",15,1.26202903,8,0.514643505,2.4522393,1.29409977,0.034966987,0.019248798,"up","yes","Myo18b","protein_coding","chr12:43747010-43953695:+","gi|564379982|ref|XP_006249639.1|",12086,0,"PREDICTED: unconventional myosin-XVIIIb isoform X2 [Rattus norvegicus]","gi|672073436|ref|XM_006249577.2|",8337,0,"PREDICTED: Rattus norvegicus myosin XVIIIb (Myo18b), transcript variant X2, mRNA","Q8IUG5",3209,0,"Unconventional myosin-XVIIIb","SPAC4A8.05c",264,{"v":1e-69,"d":"1.00E-69"},"COG5022","pfam00063","Myosin_head","Myosin head (motor domain).","GO:0001570|vasculogenesis;GO:0001701|in utero embryonic development;GO:0055013|cardiac muscle cell development;","GO:0016461|unconventional myosin complex;GO:0030018|Z disc;GO:0031941|filamentous actin;","GO:0003774|motor activity;GO:0003779|actin binding;GO:0005524|ATP binding;","K10362","MYO18; myosin XVIII"]
["ENSRNOG00000063760",15,1.26202903,8,0.514643505,2.4522393,1.29409977,0.034966987,0.019248798,"up","yes","ENSRNOG00000063760","lncRNA","chr7:132354681-132359869:+",".",".",".",".","gi|672022399|ref|XR_348274.2|",2433,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102556412 (LOC102556412), ncRNA",".",".",".",".",".",".",".",".","pfam06621","SIM_C","Single-minded protein C-terminus. This family represents the C-terminal region of the eukaryotic single-minded (SIM) protein. Drosophila single-minded acts as a positive master gene regulator in central nervous system midline formation. There are two homologues in mammals: SIM1 and SIM2, which are members of the basic-helix-loop-helix PAS family of transcription factors. SIM1 and SIM2 are novel heterodimerization partners for ARNT in vitro, and they may function both as positive and negative transcriptional regulators in vivo, during embryogenesis and in the adult organism. SIM2 is thought to contribute to some specific Down syndrome phenotypes. This family is found in conjunction with a pfam00989 domain and associated pfam00785 motif.",".",".",".",".","."]
["ENSRNOG00000002417",7,0.588946881,2,0.128660876,4.57751336,2.194564097,0.036620418,0.020029386,"up","yes","Serpinb10","protein_coding","chr13:23553430-23571182:+","gi|149037258|gb|EDL91758.1|",2109,0,"serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10 [Rattus norvegicus]","gi|42476311|ref|NM_153733.2|",1401,0,"Rattus norvegicus serpin peptidase inhibitor, clade B (ovalbumin), member 10 (Serpinb10), mRNA","Q8K3K4",801,0,"Serpin B10","MA3388",174,{"v":7e-48,"d":"7.00E-48"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0010951|negative regulation of endopeptidase activity;GO:0045861|negative regulation of proteolysis;","GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0004867|serine-type endopeptidase inhibitor activity;GO:0030414|peptidase inhibitor activity;","K13963","SERPINB; serpin B"]
["ENSRNOG00000010507",7,0.588946881,2,0.128660876,4.57751336,2.194564097,0.036620418,0.020029386,"up","yes","Mmp7","protein_coding","chr8:4848186-4855902:+","gi|6981214|ref|NP_036996.1|",1414,0,"matrilysin precursor [Rattus norvegicus]","gi|166091437|ref|NM_012864.2|",804,0,"Rattus norvegicus matrix metallopeptidase 7 (Mmp7), mRNA","P50280",549,0,"Matrilysin",".",".",".",".","pfam00413","Peptidase_M10","Matrixin. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.","GO:0002779|antibacterial peptide secretion;GO:0002780|antibacterial peptide biosynthetic process;GO:0006508|proteolysis;GO:0006509|membrane protein ectodomain proteolysis;GO:0007568|aging;GO:0009410|response to xenobiotic stimulus;GO:0030198|extracellular matrix organization;GO:0030335|positive regulation of cell migration;GO:0030574|collagen catabolic process;GO:0031293|membrane protein intracellular domain proteolysis;GO:0031667|response to nutrient levels;GO:0042127|regulation of cell proliferation;GO:0042742|defense response to bacterium;GO:0044849|estrous cycle;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:0060135|maternal process involved in female pregnancy;GO:0071260|cellular response to mechanical stimulus;","GO:0005615|extracellular space;GO:0009986|cell surface;GO:0031012|extracellular matrix;","GO:0004175|endopeptidase activity;GO:0004222|metalloendopeptidase activity;GO:0008201|heparin binding;GO:0008233|peptidase activity;GO:0008237|metallopeptidase activity;GO:0008270|zinc ion binding;","K01397","MMP7; matrix metalloproteinase-7 (matrilysin, uterine) [EC:3.4.24.23]"]
["ENSRNOG00000015750",7,0.588946881,2,0.128660876,4.57751336,2.194564097,0.036620418,0.020029386,"up","yes","Wnt7b","protein_coding","chr7:116634814-116679581:-","gi|57527452|ref|NP_001009695.1|",1797,0,"protein Wnt-7b [Rattus norvegicus]","gi|254692921|ref|NM_009528.3|",2622,0,"Mus musculus wingless-type MMTV integration site family, member 7B (Wnt7b), transcript variant 1, mRNA","P28047",696,0,"Protein Wnt-7b",".",".",".",".","pfam00110","wnt","wnt family. Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.","GO:0001525|angiogenesis;GO:0001701|in utero embryonic development;GO:0001944|vasculature development;GO:0003338|metanephros morphogenesis;GO:0008284|positive regulation of cell proliferation;GO:0010628|positive regulation of gene expression;GO:0016055|Wnt signaling pathway;GO:0016332|establishment or maintenance of polarity of embryonic epithelium;GO:0021846|cell proliferation in forebrain;GO:0021871|forebrain regionalization;GO:0022009|central nervous system vasculogenesis;GO:0030182|neuron differentiation;GO:0030324|lung development;GO:0031175|neuron projection development;GO:0032364|oxygen homeostasis;GO:0032536|regulation of cell projection size;GO:0036516|chemoattraction of dopaminergic neuron axon;GO:0042475|odontogenesis of dentin-containing tooth;GO:0042592|homeostatic process;GO:0044237|cellular metabolic process;GO:0045165|cell fate commitment;GO:0045669|positive regulation of osteoblast differentiation;GO:0045879|negative regulation of smoothened signaling pathway;GO:0046330|positive regulation of JNK cascade;GO:0048144|fibroblast proliferation;GO:0048568|embryonic organ development;GO:0048812|neuron projection morphogenesis;GO:0048864|stem cell development;GO:0050768|negative regulation of neurogenesis;GO:0050808|synapse organization;GO:0051145|smooth muscle cell differentiation;GO:0051384|response to glucocorticoid;GO:0060033|anatomical structure regression;GO:0060070|canonical Wnt signaling pathway;GO:0060425|lung morphogenesis;GO:0060428|lung epithelium development;GO:0060482|lobar bronchus development;GO:0060484|lung-associated mesenchyme development;GO:0060535|trachea cartilage morphogenesis;GO:0060560|developmental growth involved in morphogenesis;GO:0060669|embryonic placenta morphogenesis;GO:0060710|chorio-allantoic fusion;GO:0061180|mammary gland epithelium development;GO:0071300|cellular response to retinoic acid;GO:0072053|renal inner medulla development;GO:0072054|renal outer medulla development;GO:0072060|outer medullary collecting duct development;GO:0072061|inner medullary collecting duct development;GO:0072089|stem cell proliferation;GO:0072205|metanephric collecting duct development;GO:0072207|metanephric epithelium development;GO:0072236|metanephric loop of Henle development;GO:1902262|apoptotic process involved in blood vessel morphogenesis;GO:1904938|planar cell polarity pathway involved in axon guidance;","GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0005886|plasma membrane;GO:0009986|cell surface;","GO:0003674|molecular_function;GO:0005109|frizzled binding;GO:0005125|cytokine activity;GO:0048018|receptor ligand activity;GO:1902379|chemoattractant activity involved in axon guidance;","K00572","WNT7; wingless-type MMTV integration site family, member 7"]
["ENSRNOG00000019355",7,0.588946881,2,0.128660876,4.57751336,2.194564097,0.036620418,0.020029386,"up","yes","Lman1l","protein_coding","chr8:58010839-58023681:-","gi|149041802|gb|EDL95643.1|",2457,0,"lectin, mannose-binding, 1 like [Rattus norvegicus]","gi|60223054|ref|NM_001012465.1|",1572,0,"Rattus norvegicus lectin, mannose-binding, 1 like (Lman1l), mRNA","Q5FB95",948,0,"Protein ERGIC-53-like",".",".",".",".","pfam03388","Lectin_leg-like","Legume-like lectin family. Lectins are structurally diverse proteins that bind to specific carbohydrates. This family includes the VIP36 and ERGIC-53 lectins. These two proteins were the first recognized members of a family of animal lectins similar (19-24%) to the leguminous plant lectins. The alignment for this family aligns residues lying towards the N-terminus, where the similarity of VIP36 and ERGIC-53 is greatest. However, while Fiedler and Simons identified these proteins as a new family of animal lectins, our alignment also includes yeast sequences. ERGIC-53 is a 53kD protein, localized to the intermediate region between the endoplasmic reticulum and the Golgi apparatus (ER-Golgi-Intermediate Compartment, ERGIC). It was identified as a calcium-dependent, mannose-specific lectin. Its dysfunction has been associated with combined factors V and VIII deficiency OMIM:227300 OMIM:601567, suggesting an important and substrate-specific role for ERGIC-53 in the glycoprotein- secreting pathway.","GO:0006888|ER to Golgi vesicle-mediated transport;GO:0007029|endoplasmic reticulum organization;GO:0007030|Golgi organization;","GO:0000139|Golgi membrane;GO:0005789|endoplasmic reticulum membrane;GO:0005793|endoplasmic reticulum-Golgi intermediate compartment;GO:0016021|integral component of membrane;GO:0030134|COPII-coated ER to Golgi transport vesicle;GO:0033116|endoplasmic reticulum-Golgi intermediate compartment membrane;","GO:0005537|mannose binding;","K10081","LMAN1L, ERGL; lectin, mannose-binding 1-like"]
["ENSRNOG00000020377",7,0.588946881,2,0.128660876,4.57751336,2.194564097,0.036620418,0.020029386,"up","yes","Cideb","protein_coding","chr15:29252213-29256605:-","gi|564386225|ref|XP_006252064.1|",987,{"v":3e-128,"d":"3.00E-128"},"PREDICTED: cell death activator CIDE-B isoform X1 [Rattus norvegicus]","gi|672078087|ref|XM_006252002.2|",696,0,"PREDICTED: Rattus norvegicus cell death-inducing DFFA-like effector b (Cideb), transcript variant X1, mRNA","O70303",280,{"v":1E-89,"d":"1.00E-89"},"Cell death activator CIDE-B",".",".",".",".","pfam02017","CIDE-N","CIDE-N domain. This domain is found in CAD nuclease, and in ICAD, the inhibitor of CAD nuclease. The two proteins interact through this domain.","GO:0006915|apoptotic process;GO:0010942|positive regulation of cell death;GO:0031667|response to nutrient levels;GO:0038183|bile acid signaling pathway;GO:0042981|regulation of apoptotic process;GO:0090200|positive regulation of release of cytochrome c from mitochondria;GO:0097194|execution phase of apoptosis;GO:0097202|activation of cysteine-type endopeptidase activity;","GO:0005829|cytosol;GO:0048471|perinuclear region of cytoplasm;","GO:0042802|identical protein binding;",".","."]
["ENSRNOG00000032951",7,0.588946881,2,0.128660876,4.57751336,2.194564097,0.036620418,0.020029386,"up","yes","Jsrp1","protein_coding","chr7:8901609-8906055:+","gi|157819085|ref|NP_001103061.1|",767,{"v":2E-95,"d":"2.00E-95"},"junctional sarcoplasmic reticulum protein 1 [Rattus norvegicus]","gi|157819084|ref|NM_001109591.1|",1085,0,"Rattus norvegicus junctional sarcoplasmic reticulum protein 1 (Jsrp1), mRNA","Q3MI48",226,{"v":1e-68,"d":"1.00E-68"},"Junctional sarcoplasmic reticulum protein 1",".",".",".",".","pfam15312","JSRP","Junctional sarcoplasmic reticulum protein. JSRP, junctional sarcoplasmic reticulum protein 1, or junctional-face membrane protein of 45 kDa homologue, is a family of eukaryotic proteins. The family is to the junctional face membrane of the skeletal muscle sarcoplasmic reticulum (SR); it colocalizes with its Ca2+-release channel (the ryanodine receptor), and interacts with calsequestrin and the skeletal-muscle dihydro-pyridine receptor Cav1. It is key for the functional expression of voltage-dependent Ca2+ channels.","GO:0003009|skeletal muscle contraction;GO:0060314|regulation of ryanodine-sensitive calcium-release channel activity;GO:0072657|protein localization to membrane;","GO:0016529|sarcoplasmic reticulum;",".",".","."]
["ENSRNOG00000045587",7,0.588946881,2,0.128660876,4.57751336,2.194564097,0.036620418,0.020029386,"up","yes","Vom2r76","protein_coding","chr9:9467905-9492564:+","gi|154146264|ref|NP_001092975.1|",4461,0,"vomeronasal 2 receptor, 76 precursor [Rattus norvegicus]","gi|154146263|ref|NM_001099505.1|",2592,0,"Rattus norvegicus vomeronasal 2 receptor, 76 (Vom2r76), mRNA","E9Q6I0",655,0,"Vomeronasal type-2 receptor 116",".",".",".",".","pfam00003","7tm_3","7 transmembrane sweet-taste receptor of 3 GCPR. This is a domain of seven transmembrane regions that forms the C-terminus of some subclass 3 G-coupled-protein receptors. It is often associated with a downstream cysteine-rich linker domain, NCD3G pfam07562, which is the human sweet-taste receptor, and the N-terminal domain, ANF_receptor pfam01094. The seven TM regions assemble in such a way as to produce a docking pocket into which such molecules as cyclamate and lactisole have been found to bind and consequently confer the taste of sweetness.","GO:0007186|G protein-coupled receptor signaling pathway;","GO:0005887|integral component of plasma membrane;","GO:0004930|G protein-coupled receptor activity;","K04613","V2R; vomeronasal 2 receptor"]
["ENSRNOG00000064300",7,0.588946881,2,0.128660876,4.57751336,2.194564097,0.036620418,0.020029386,"up","yes","ENSRNOG00000064300","lncRNA","chr8:67624919-67631930:+",".",".",".",".","gi|75750691|gb|AC166370.3|",327,{"v":6e-169,"d":"6.00E-169"},"Mus musculus BAC clone RP23-20I24 from chromosome 9, complete sequence",".",".",".",".",".",".",".",".","pfam15268","Dapper","Dapper. This is a family of signalling proteins. They act in a diverse range of signaling pathways and have a range of binding partners. They act as homo- and heterodimers.",".",".",".",".","."]
["ENSRNOG00000065539",7,0.588946881,2,0.128660876,4.57751336,2.194564097,0.036620418,0.020029386,"up","yes","ENSRNOG00000065539","protein_coding","chr1:63799671-63800321:-","gi|21704148|ref|NP_663546.1|",1162,{"v":6e-160,"d":"6.00E-160"},"MOB kinase activator 1A [Mus musculus]","gi|76559916|ref|NM_001033891.1|",639,0,"Rattus norvegicus MOB kinase activator 1A (Mob1a), mRNA","Q3T1J9",452,{"v":2e-161,"d":"2.00E-161"},"MOB kinase activator 1A",".",".",".",".","pfam03637","Mob1_phocein","Mob1/phocein family. Mob1 is an essential Saccharomyces cerevisiae protein, identified from a two-hybrid screen, that binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Mob1 contains no known structural motifs; however MOB1 is a member of a conserved gene family and shares sequence similarity with a nonessential yeast gene, MOB2. Mob1 is a phosphoprotein in vivo and a substrate for the Mps1p kinase in vitro. Conditional alleles of MOB1 cause a late nuclear division arrest at restrictive temperature. This family also includes phocein, a rat protein that by yeast two hybrid interacts with striatin.",".",".",".",".","."]
["ENSRNOG00000065653",7,0.588946881,2,0.128660876,4.57751336,2.194564097,0.036620418,0.020029386,"up","yes","ENSRNOG00000065653","lncRNA","chr20:18187827-18189088:+",".",".",".",".","gi|354793435|gb|JN957936.1|",295,{"v":3e-151,"d":"3.00E-151"},"Mus musculus targeted deletion, lacZ-tagged mutant allele Fam13c:tm1(KOMP)Wtsi; transgenic",".",".",".",".",".",".",".",".","pfam15616","TerY-C","TerY-C metal binding domain. TerY-C is found C terminal to TerY-like vWA domains in some proteins. It has 8 conserved metal chelating cysteines or histidines. It occasionaly occurs as solos.",".",".",".",".","."]
["ENSRNOG00000066250",7,0.588946881,2,0.128660876,4.57751336,2.194564097,0.036620418,0.020029386,"up","yes","ENSRNOG00000066250","lncRNA","chr16:27952056-27959253:+",".",".",".",".","gi|298898473|emb|FQ231461.1|",756,0,"Rattus norvegicus TL0AEA6YG15 mRNA sequence",".",".",".",".",".",".",".",".","pfam00798","Arena_glycoprot","Arenavirus glycoprotein.",".",".",".",".","."]
["ENSRNOG00000068191",7,0.588946881,2,0.128660876,4.57751336,2.194564097,0.036620418,0.020029386,"up","yes","ENSRNOG00000068191","lncRNA","chr19:47392403-47400874:-",".",".",".",".","gi|25136968|emb|AL691505.12|",115,{"v":1E-51,"d":"1.00E-51"},"Mouse DNA sequence from clone RP23-82B19 on chromosome 10, complete sequence",".",".",".",".",".",".",".",".","pfam13413","HTH_25","Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.",".",".",".",".","."]
["ENSRNOG00000068698",7,0.588946881,2,0.128660876,4.57751336,2.194564097,0.036620418,0.020029386,"up","yes","ENSRNOG00000068698","pseudogene","chr1:106682457-106683115:+","gi|537236584|gb|ERE85696.1|",493,{"v":6e-60,"d":"6.00E-60"},"dynein light chain 1, cytoplasmic-like protein [Cricetulus griseus]","gi|38649326|gb|BC063183.1|",563,0,"Rattus norvegicus dynein light chain LC8-type 1, mRNA (cDNA clone MGC:72986 IMAGE:6887897), complete cds","P63170",156,{"v":6e-47,"d":"6.00E-47"},"Dynein light chain 1, cytoplasmic",".",".",".",".","pfam01221","Dynein_light","Dynein light chain type 1.",".",".",".",".","."]
["ENSRNOG00000069173",7,0.588946881,2,0.128660876,4.57751336,2.194564097,0.036620418,0.020029386,"up","yes","RGD1563285","protein_coding","chr1:185084261-185092190:+","gi|672014335|ref|XP_008772894.1|",1012,{"v":5e-161,"d":"5.00E-161"},"PREDICTED: uncharacterized protein RGD1563285 isoform X1 [Rattus norvegicus]","gi|672038724|ref|XM_008759947.1|",788,0,"PREDICTED: Rattus norvegicus similar to RIKEN cDNA 1700022C21 (RGD1563285), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam05832","DUF846","Eukaryotic protein of unknown function (DUF846). This family consists of several of unknown function from a variety of eukaryotic organisms.",".",".",".",".","."]
["ENSRNOG00000069730",7,0.588946881,2,0.128660876,4.57751336,2.194564097,0.036620418,0.020029386,"up","yes","ENSRNOG00000069730","lncRNA","chr13:46719615-46727054:-","gi|148692632|gb|EDL24579.1|",126,{"v":1e-06,"d":"1.00E-06"},"mCG145399, partial [Mus musculus]","gi|354788836|gb|JN953337.1|",241,{"v":2E-121,"d":"2.00E-121"},"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Timm17a:tm1a(EUCOMM)Hmgu; transgenic",".",".",".",".",".",".",".",".","pfam05525","Branch_AA_trans","Branched-chain amino acid transport protein. This family consists of several bacterial branched-chain amino acid transport proteins which are responsible for the transport of leucine, isoleucine and valine via proton motive force.",".",".",".",".","."]
["ENSRNOG00000042478",16,1.346164298,9,0.578973944,2.325086151,1.217284173,0.037887173,0.020612492,"up","yes","Adam22","protein_coding","chr4:25715990-25964962:+","gi|568932702|ref|XP_006503598.1|",4328,0,"PREDICTED: disintegrin and metalloproteinase domain-containing protein 22 isoform X8 [Mus musculus]","gi|755510619|ref|XM_006503535.2|",2704,0,"PREDICTED: Mus musculus a disintegrin and metallopeptidase domain 22 (Adam22), transcript variant X8, mRNA","Q9R1V6",1607,0,"Disintegrin and metalloproteinase domain-containing protein 22",".",".",".",".","pfam01421","Reprolysin","Reprolysin (M12B) family zinc metalloprotease. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as human ADAM8 and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.","GO:0006508|proteolysis;GO:0008344|adult locomotory behavior;GO:0014037|Schwann cell differentiation;GO:0022011|myelination in peripheral nervous system;GO:0042063|gliogenesis;GO:0099645|neurotransmitter receptor localization to postsynaptic specialization membrane;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0030424|axon;GO:0098978|glutamatergic synapse;GO:0099061|integral component of postsynaptic density membrane;","GO:0004222|metalloendopeptidase activity;","K16068","ADAM22; disintegrin and metalloproteinase domain-containing protein 22 [EC:3.4.24.-]"]
["ENSRNOG00000070333",16,1.346164298,9,0.578973944,2.325086151,1.217284173,0.037887173,0.020612492,"up","yes","ENSRNOG00000070333","lncRNA","chr2:120843930-120908257:+","gi|149048778|gb|EDM01319.1|",146,{"v":8e-08,"d":"8.00E-08"},"rCG41382 [Rattus norvegicus]","gi|28604199|gb|AC129177.3|",950,0,"Mus musculus BAC clone RP23-175A22 from 3, complete sequence",".",".",".",".",".",".",".",".","pfam01930","Cas_Cas4","Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C terminus.",".",".",".",".","."]
["ENSRNOG00000028580",17,1.430299567,10,0.643304382,2.223363632,1.152743921,0.040432959,0.021771285,"up","yes","Pcnx2","protein_coding","chr19:53718655-53871364:-","gi|564396366|ref|XP_006255883.1|",10376,0,"PREDICTED: pecanex-like protein 2 isoform X2 [Rattus norvegicus]","gi|672085449|ref|XM_006255821.2|",7886,0,"PREDICTED: Rattus norvegicus pecanex-like 2 (Drosophila) (Pcnxl2), transcript variant X2, mRNA","Q5DU28",3698,0,"Pecanex-like protein 2",".",".",".",".","pfam05041","Pecanex_C","Pecanex protein (C-terminus). This family consists of C terminal region of the pecanex protein homologues. The pecanex protein is a maternal-effect neurogenic gene found in Drosophila.",".","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000008264",11,0.925487955,5,0.321652191,2.877294112,1.524712698,0.040926675,0.022015357,"up","yes","Fndc8","protein_coding","chr10:67825952-67834090:+","gi|157823239|ref|NP_001100500.1|",1568,0,"fibronectin type III domain-containing protein 8 [Rattus norvegicus]","gi|157823238|ref|NM_001107030.1|",2406,0,"Rattus norvegicus fibronectin type III domain containing 8 (Fndc8), mRNA",".",".",".",".",".",".",".",".","pfam00041","fn3","Fibronectin type III domain.","GO:0008150|biological_process;","GO:0005575|cellular_component;","GO:0003674|molecular_function;","K24488","FNDC8; fibronectin type III domain-containing protein 8"]
["ENSRNOG00000019770",11,0.925487955,5,0.321652191,2.877294112,1.524712698,0.040926675,0.022015357,"up","yes","Bnc1","protein_coding","chr1:135917687-135943333:-","gi|157821307|ref|NP_001102386.1|",4685,0,"zinc finger protein basonuclin-1 [Rattus norvegicus]","gi|157821306|ref|NM_001108916.1|",4722,0,"Rattus norvegicus basonuclin 1 (Bnc1), mRNA","O35914",1702,0,"Zinc finger protein basonuclin-1",".",".",".",".","pfam13894","zf-C2H2_4","C2H2-type zinc finger. This family contains a number of divergent C2H2 type zinc fingers.","GO:0006355|regulation of transcription, DNA-templated;GO:0006356|regulation of transcription by RNA polymerase I;GO:0006357|regulation of transcription by RNA polymerase II;GO:0042060|wound healing;GO:0045943|positive regulation of transcription by RNA polymerase I;GO:0050679|positive regulation of epithelial cell proliferation;GO:0051276|chromosome organization;GO:1900195|positive regulation of oocyte maturation;","GO:0005634|nucleus;GO:0005654|nucleoplasm;GO:0005730|nucleolus;GO:0005737|cytoplasm;GO:0043231|intracellular membrane-bounded organelle;","GO:0000182|rDNA binding;GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0001216|bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding;","K24146","BNC; zinc finger protein basonuclin"]
["ENSRNOG00000035513",11,0.925487955,5,0.321652191,2.877294112,1.524712698,0.040926675,0.022015357,"up","yes","Mir214","miRNA","chr13:74588372-74588481:+",".",".",".",".","gi|987976947|emb|LT160000.1|",110,{"v":2e-49,"d":"2.00E-49"},"Macaca fascicularis complete genome, chromosome chr1",".",".",".",".",".",".",".",".","pfam00303","Thymidylat_synt","Thymidylate synthase.","GO:0045591|positive regulation of regulatory T cell differentiation;",".",".",".","."]
["ENSRNOG00000052405",11,0.925487955,5,0.321652191,2.877294112,1.524712698,0.040926675,0.022015357,"up","yes","Cdh4","protein_coding","chr3:166525099-167003371:+","gi|109471524|ref|XP_001061943.1|",4417,0,"PREDICTED: cadherin-4 isoform X1 [Rattus norvegicus]","gi|672017876|ref|XM_001061943.5|",6148,0,"PREDICTED: Rattus norvegicus cadherin 4 (Cdh4), transcript variant X1, mRNA","P39038",1659,0,"Cadherin-4",".",".",".",".","pfam01049","Cadherin_C","Cadherin cytoplasmic region. Cadherins are vital in cell-cell adhesion during tissue differentiation. Cadherins are linked to the cytoskeleton by catenins. Catenins bind to the cytoplasmic tail of the cadherin. Cadherins cluster to form foci of homophilic binding units. A key determinant to the strength of the binding that it is mediated by cadherins is the juxtamembrane region of the cadherin. This region induces clustering and also binds to the protein p120ctn.","GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007411|axon guidance;GO:0045773|positive regulation of axon extension;GO:0098742|cell-cell adhesion via plasma-membrane adhesion molecules;","GO:0005886|plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016342|catenin complex;","GO:0005509|calcium ion binding;GO:0045296|cadherin binding;","K06797","CDH4; cadherin 4, type 1, R-cadherin"]
["ENSRNOG00000005727",19,1.598570104,12,0.771965258,2.070779853,1.050174187,0.044524749,0.023746733,"up","yes","Galnt3","protein_coding","chr3:50742512-50766268:-","gi|75832150|ref|NP_001015032.2|",3433,0,"polypeptide N-acetylgalactosaminyltransferase 3 [Rattus norvegicus]","gi|672045842|ref|XM_006234290.2|",2747,0,"PREDICTED: Rattus norvegicus polypeptide N-acetylgalactosaminyltransferase 3 (Galnt3), transcript variant X1, mRNA","P70419",1305,0,"Polypeptide N-acetylgalactosaminyltransferase 3","Rv0696",59.7,{"v":2E-8,"d":"2.00E-08"},"COG0463","pfam00535","Glycos_transf_2","Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.","GO:0006493|protein O-linked glycosylation;GO:0007283|spermatogenesis;GO:0008150|biological_process;GO:0018242|protein O-linked glycosylation via serine;GO:0018243|protein O-linked glycosylation via threonine;","GO:0000139|Golgi membrane;GO:0005575|cellular_component;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;GO:0048471|perinuclear region of cytoplasm;","GO:0003674|molecular_function;GO:0004653|polypeptide N-acetylgalactosaminyltransferase activity;GO:0005509|calcium ion binding;GO:0030145|manganese ion binding;GO:0030246|carbohydrate binding;","K00710","GALNT; polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41]"]
["ENSRNOG00000042726",19,1.598570104,12,0.771965258,2.070779853,1.050174187,0.044524749,0.023746733,"up","yes","RGD1560775","protein_coding","chr8:89601651-89682461:-","gi|672023158|ref|XP_008756054.1|",2379,0,"PREDICTED: uncharacterized protein RGD1560775 isoform X3 [Rattus norvegicus]","gi|672023156|ref|XR_589067.1|",1335,0,"PREDICTED: Rattus norvegicus similar to RIKEN cDNA 4930579C12 gene (RGD1560775), transcript variant X3, misc_RNA",".",".",".",".",".",".",".",".","pfam15008","DUF4518","Domain of unknown function (DUF4518). The precise function of this protein family is unknown but it is thought to be involved in apoptosis regulation.",".",".",".",".","."]
["ENSRNOG00000071099",19,1.598570104,12,0.771965258,2.070779853,1.050174187,0.044524749,0.023746733,"up","yes","ENSRNOG00000071099","lncRNA","chrX:14924936-14929098:-","gi|149028464|gb|EDL83849.1|",273,{"v":9e-27,"d":"9.00E-27"},"rCG22867 [Rattus norvegicus]","gi|12407642|gb|AF277994.1|AF277994",168,{"v":1e-80,"d":"1.00E-80"},"Mus musculus scurfin (Foxp3) gene, complete cds",".",".",".",".",".",".",".",".","pfam14654","Epiglycanin_C","Mucin, catalytic, TM and cytoplasmic tail region. This family represents the non-tandem repeat domain including cleavage site, the transmembrane helix domain, and the cytoplasmic tail of epiglycanin and related mucins.",".",".",".",".","."]
["ENSRNOG00000003288",5,0.420676343,1,0.064330438,6.5393048,2.70913727,0.046097741,0.024473002,"up","yes","Cacng5","protein_coding","chr10:92829196-92869614:-","gi|21687012|ref|NP_542424.1|",1369,0,"voltage-dependent calcium channel gamma-5 subunit [Rattus norvegicus]","gi|313151227|ref|NM_001199301.1|",1398,0,"Mus musculus calcium channel, voltage-dependent, gamma subunit 5 (Cacng5), transcript variant 1, mRNA","Q8VHW8",531,0,"Voltage-dependent calcium channel gamma-5 subunit",".",".",".",".","pfam00822","PMP22_Claudin","PMP-22/EMP/MP20/Claudin family.","GO:0019226|transmission of nerve impulse;GO:0051968|positive regulation of synaptic transmission, glutamatergic;GO:0070588|calcium ion transmembrane transport;GO:0098943|neurotransmitter receptor transport, postsynaptic endosome to lysosome;GO:0098962|regulation of postsynaptic neurotransmitter receptor activity;GO:0098970|postsynaptic neurotransmitter receptor diffusion trapping;GO:0099590|neurotransmitter receptor internalization;GO:2000311|regulation of AMPA receptor activity;","GO:0014069|postsynaptic density;GO:0032281|AMPA glutamate receptor complex;GO:0098839|postsynaptic density membrane;GO:0098978|glutamatergic synapse;GO:0099055|integral component of postsynaptic membrane;","GO:0005245|voltage-gated calcium channel activity;GO:0005515|protein binding;GO:0016247|channel regulator activity;","K04870","CACNG5; voltage-dependent calcium channel gamma-5"]
["ENSRNOG00000009316",5,0.420676343,1,0.064330438,6.5393048,2.70913727,0.046097741,0.024473002,"up","yes","Bmp10","protein_coding","chr4:119872045-119878627:+","gi|73532772|ref|NP_001026994.1|",2145,0,"bone morphogenetic protein 10 precursor [Rattus norvegicus]","gi|71891582|dbj|AB158418.1|",1266,0,"Rattus norvegicus Bmp10 mRNA for bone morphogenetic protein 10, complete cds, strain:LEC/Crj","Q4AEG6",830,0,"Bone morphogenetic protein 10",".",".",".",".","pfam00019","TGF_beta","Transforming growth factor beta like domain.","GO:0001822|kidney development;GO:0007155|cell adhesion;GO:0007507|heart development;GO:0007512|adult heart development;GO:0010596|negative regulation of endothelial cell migration;GO:0010613|positive regulation of cardiac muscle hypertrophy;GO:0010614|negative regulation of cardiac muscle hypertrophy;GO:0010628|positive regulation of gene expression;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0030308|negative regulation of cell growth;GO:0030336|negative regulation of cell migration;GO:0030509|BMP signaling pathway;GO:0032924|activin receptor signaling pathway;GO:0045214|sarcomere organization;GO:0045893|positive regulation of transcription, DNA-templated;GO:0055009|atrial cardiac muscle tissue morphogenesis;GO:0055010|ventricular cardiac muscle tissue morphogenesis;GO:0055015|ventricular cardiac muscle cell development;GO:0055117|regulation of cardiac muscle contraction;GO:0060038|cardiac muscle cell proliferation;GO:0060045|positive regulation of cardiac muscle cell proliferation;GO:0060298|positive regulation of sarcomere organization;GO:0060347|heart trabecula formation;GO:0060389|pathway-restricted SMAD protein phosphorylation;GO:0060395|SMAD protein signal transduction;GO:0061036|positive regulation of cartilage development;GO:1903242|regulation of cardiac muscle hypertrophy in response to stress;GO:2000138|positive regulation of cell proliferation involved in heart morphogenesis;","GO:0005575|cellular_component;GO:0005615|extracellular space;GO:0005737|cytoplasm;GO:0009986|cell surface;GO:0030018|Z disc;","GO:0003674|molecular_function;GO:0005125|cytokine activity;GO:0005179|hormone activity;GO:0008083|growth factor activity;GO:0031433|telethonin binding;GO:0033612|receptor serine/threonine kinase binding;","K22670","BMP10; bone morphogenetic protein 10"]
["ENSRNOG00000012920",5,0.420676343,1,0.064330438,6.5393048,2.70913727,0.046097741,0.024473002,"up","yes","Col9a1","protein_coding","chr9:26585034-26668213:+","gi|28422746|gb|AAH46970.1|",2218,0,"Col9a1 protein [Mus musculus]","gi|281604199|ref|NM_001100842.1|",3801,0,"Rattus norvegicus collagen, type IX, alpha 1 (Col9a1), mRNA","Q05722",526,{"v":3e-166,"d":"3.00E-166"},"Collagen alpha-1(IX) chain",".",".",".",".","pfam01391","Collagen","Collagen triple helix repeat (20 copies). Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxyproline. Collagens are post translationally modified by proline hydroxylase to form the hydroxyproline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure.","GO:0001501|skeletal system development;GO:0001894|tissue homeostasis;GO:0002062|chondrocyte differentiation;GO:0003417|growth plate cartilage development;GO:0030198|extracellular matrix organization;GO:0035988|chondrocyte proliferation;GO:0051216|cartilage development;GO:0060349|bone morphogenesis;","GO:0005575|cellular_component;GO:0005594|collagen type IX trimer;GO:0005604|basement membrane;GO:0005615|extracellular space;GO:0031012|extracellular matrix;","GO:0003674|molecular_function;GO:0005201|extracellular matrix structural constituent;GO:0046872|metal ion binding;","K08131","COL9A; collagen type IX alpha"]
["ENSRNOG00000014979",5,0.420676343,1,0.064330438,6.5393048,2.70913727,0.046097741,0.024473002,"up","yes","Themis","protein_coding","chr1:16432631-16664329:-","gi|149039656|gb|EDL93818.1|",3298,0,"rCG57294, isoform CRA_a [Rattus norvegicus]","gi|672033934|ref|XM_008758640.1|",2293,0,"PREDICTED: Rattus norvegicus thymocyte selection associated (Themis), transcript variant X2, mRNA","Q8BGW0",1158,0,"Protein THEMIS",".",".",".",".","pfam12736","CABIT","Cell-cycle sustaining, positive selection,. The 'CABIT' domain (for 'cysteine-containing, all- in Themis') is found in a newly identified gene family that has three mammalian homologues (Themis, Icb1 and 9130404H23Rik) that encode proteins with two CABIT domains and a highly conserved proline-rich region. In contrast, Fam59A, Fam59B and related proteins from mammals to cnidarians, including the insect Serrano proteins, have a single copy of the CABIT domain, a proline-rich region and often a C-terminal SAM (sterile-motif) domain. Multiple-sequence alignment has predicted that the CABIT domain adopts an all-strand structure with at least 12 strands, ie a dyad of six-stranded beta-barrel units. The CABIT domain contains a nearly absolutely conserved cysteine residue which is likely to be central to its function. CABIT domain proteins function downstream of tyrosine kinase signalling and interact with GRB2.","GO:0043368|positive T cell selection;GO:0043383|negative T cell selection;GO:0050852|T cell receptor signaling pathway;","GO:0005634|nucleus;GO:0005737|cytoplasm;GO:0005911|cell-cell junction;GO:0008180|COP9 signalosome;",".",".","."]
["ENSRNOG00000015161",5,0.420676343,1,0.064330438,6.5393048,2.70913727,0.046097741,0.024473002,"up","yes","ENSRNOG00000015161","pseudogene","chr18:50004134-50004984:-","gi|38051979|gb|AAH60558.1|",1462,0,"Vdac1 protein, partial [Rattus norvegicus]","gi|672030703|ref|XR_085675.5|",844,0,"PREDICTED: Rattus norvegicus similar to Voltage-dependent anion-selective channel protein 1 (VDAC-1) (mVDAC1) (mVDAC5) (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (LOC688754), misc_RNA","Q9Z2L0",566,0,"Voltage-dependent anion-selective channel protein 1",".",".",".",".","pfam01459","Porin_3","Eukaryotic porin.",".",".",".",".","."]
["ENSRNOG00000016275",5,0.420676343,1,0.064330438,6.5393048,2.70913727,0.046097741,0.024473002,"up","yes","Ttr","protein_coding","chr18:11943789-11951008:+","gi|333033763|ref|NP_036813.2|",755,{"v":7e-99,"d":"7.00E-99"},"transthyretin precursor [Rattus norvegicus]","gi|564392776|ref|XM_006254457.1|",676,0,"PREDICTED: Rattus norvegicus transthyretin (Ttr), transcript variant X1, mRNA","P02767",295,{"v":2E-100,"d":"2.00E-100"},"Transthyretin","Cj0715",60.8,{"v":4e-11,"d":"4.00E-11"},"COG2351","pfam00576","Transthyretin","HIUase/Transthyretin family. This family includes transthyretin that is a thyroid hormone-binding protein that transports thyroxine from the bloodstream to the brain. However, most of the sequences listed in this family do not bind thyroid hormones. They are actually enzymes of the purine catabolism that catalyse the conversion of 5-hydroxyisourate (HIU) to OHCU. HIU hydrolysis is the original function of the family and is conserved from bacteria to mammals; transthyretins arose by gene duplications in the vertebrate lineage. HIUases are distinguished in the alignment from the conserved C-terminal YRGS sequence.","GO:0006144|purine nucleobase metabolic process;GO:0007165|signal transduction;GO:0042403|thyroid hormone metabolic process;GO:0042572|retinol metabolic process;GO:0070327|thyroid hormone transport;","GO:0005615|extracellular space;GO:0032991|protein-containing complex;","GO:0005179|hormone activity;GO:0036094|small molecule binding;GO:0042562|hormone binding;GO:0042802|identical protein binding;GO:0044877|protein-containing complex binding;GO:0070324|thyroid hormone binding;","K20731","TTR; transthyretin"]
["ENSRNOG00000019110",5,0.420676343,1,0.064330438,6.5393048,2.70913727,0.046097741,0.024473002,"up","yes","Ocstamp","protein_coding","chr3:154132328-154136991:-","gi|672017742|ref|XP_008773843.1|",2232,0,"PREDICTED: osteoclast stimulatory transmembrane protein [Rattus norvegicus]","gi|672017741|ref|XM_008775621.1|",1829,0,"PREDICTED: Rattus norvegicus zinc finger protein 334 (Zfp334), mRNA","Q9D611",729,0,"Osteoclast stimulatory transmembrane protein",".",".",".",".","pfam07782","DC_STAMP","DC-STAMP-like protein. This is a family of sequences which are similar to a region of the dendritic cell-specific transmembrane protein (DC-STAMP). This is thought to be a novel receptor protein that shares no identity with other multimembrane-spanning proteins. It is thought to have seven putative transmembrane regions, two of which are found in the region featured in this family. DC-STAMP is also described as having potential N-linked glycosylation sites and a potential phosphorylation site for PKC, but these are not conserved throughout the family.","GO:0034241|positive regulation of macrophage fusion;GO:0045672|positive regulation of osteoclast differentiation;GO:0071356|cellular response to tumor necrosis factor;GO:0071391|cellular response to estrogen stimulus;GO:0072674|multinuclear osteoclast differentiation;GO:0090290|positive regulation of osteoclast proliferation;","GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000020563",5,0.420676343,1,0.064330438,6.5393048,2.70913727,0.046097741,0.024473002,"up","yes","Cma1","protein_coding","chr15:29417451-29420233:-","gi|6978667|ref|NP_037224.1|",1197,{"v":7e-163,"d":"7.00E-163"},"chymase precursor [Rattus norvegicus]","gi|6978666|ref|NM_013092.1|",974,0,"Rattus norvegicus chymase 1 (Cma1), mRNA","P50339",465,{"v":2e-164,"d":"2.00E-164"},"Chymase","VC1200",58.2,{"v":1E-8,"d":"1.00E-08"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006508|proteolysis;GO:0006518|peptide metabolic process;GO:0022617|extracellular matrix disassembly;GO:0030901|midbrain development;GO:0034769|basement membrane disassembly;GO:0045766|positive regulation of angiogenesis;GO:0050727|regulation of inflammatory response;GO:0071333|cellular response to glucose stimulus;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005829|cytosol;GO:0030141|secretory granule;GO:0036464|cytoplasmic ribonucleoprotein granule;","GO:0004175|endopeptidase activity;GO:0004252|serine-type endopeptidase activity;GO:0008233|peptidase activity;GO:0008236|serine-type peptidase activity;GO:0042277|peptide binding;","K01329","CMA1; chymase [EC:3.4.21.39]"]
["ENSRNOG00000028423",5,0.420676343,1,0.064330438,6.5393048,2.70913727,0.046097741,0.024473002,"up","yes","Otop1","protein_coding","chr14:72503592-72532497:-","gi|31088856|ref|NP_852098.1|",2490,0,"otopetrin-1 [Rattus norvegicus]","gi|145208003|ref|NM_172709.3|",2104,0,"Mus musculus otopetrin 1 (Otop1), mRNA","Q7M734",963,0,"Proton channel OTOP1",".",".",".",".","pfam03189","Otopetrin","Otopetrin.","GO:0009590|detection of gravity;GO:0031214|biomineral tissue development;GO:0032869|cellular response to insulin stimulus;GO:0042472|inner ear morphogenesis;GO:0060336|negative regulation of interferon-gamma-mediated signaling pathway;GO:1902600|proton transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0016021|integral component of membrane;","GO:0015252|proton channel activity;",".","."]
["ENSRNOG00000028926",5,0.420676343,1,0.064330438,6.5393048,2.70913727,0.046097741,0.024473002,"up","yes","ENSRNOG00000028926","protein_coding","chr10:14347327-14350598:+","gi|672024613|ref|XP_008772926.1|",1242,{"v":9E-170,"d":"9.00E-170"},"PREDICTED: LOW QUALITY PROTEIN: serine protease 29 [Rattus norvegicus]","gi|672024612|ref|XM_008774704.1|",709,0,"PREDICTED: Rattus norvegicus similar to implantation serine proteinase 2 (RGD1559662), mRNA","Q99MS4",357,{"v":6e-122,"d":"6.00E-122"},"Serine protease 29","VC1649",108,{"v":8e-26,"d":"8.00E-26"},"COG5640","pfam00089","Trypsin","Trypsin.",".",".",".",".","."]
["ENSRNOG00000029459",5,0.420676343,1,0.064330438,6.5393048,2.70913727,0.046097741,0.024473002,"up","yes","AABR07021591.1","protein_coding","chr13:74582858-74583313:+","gi|51890509|dbj|BAD42838.1|",694,{"v":6e-91,"d":"6.00E-91"},"hypothetical protein [Mus musculus]","gi|311213901|ref|NR_002870.2|",383,0,"Mus musculus dynamin 3, opposite strand (Dnm3os), long non-coding RNA",".",".",".",".",".",".",".",".","pfam15242","FAM53","Family of FAM53. The FAM53 protein family refers to a family of proteins, which bind to a transcriptional regulator that modulates cell proliferation. It is known to be highly important in neural tube development. It is found in eukaryotes and is typically between 303 and 413 amino acids in length.",".",".",".",".","."]
["ENSRNOG00000033466",5,0.420676343,1,0.064330438,6.5393048,2.70913727,0.046097741,0.024473002,"up","yes","Apon","protein_coding","chr7:686927-688392:-","gi|57164117|ref|NP_001009385.1|",1210,{"v":5e-163,"d":"5.00E-163"},"apolipoprotein N precursor [Rattus norvegicus]","gi|57164116|ref|NM_001009385.1|",1238,0,"Rattus norvegicus apolipoprotein N (Apon), mRNA",".",".",".",".",".",".",".",".","pfam15148","Apolipo_F","Apolipoprotein F.","GO:0008203|cholesterol metabolic process;","GO:0005615|extracellular space;",".","K25363","APOF; apolipoprotein F"]
["ENSRNOG00000037097",5,0.420676343,1,0.064330438,6.5393048,2.70913727,0.046097741,0.024473002,"up","yes","Wfdc18","protein_coding","chr10:68588818-68589671:+","gi|312596878|ref|NP_598221.2|",328,{"v":8e-38,"d":"8.00E-38"},"WAP four-disulfide core domain protein 18 precursor [Rattus norvegicus]","gi|312596877|ref|NM_133537.2|",237,{"v":1E-119,"d":"1.00E-119"},"Rattus norvegicus WAP four-disulfide core domain 18 (Wfdc18), mRNA","P14730",127,{"v":4e-38,"d":"4.00E-38"},"WAP four-disulfide core domain protein 18 (Fragment)",".",".",".",".","pfam00095","WAP","WAP-type (Whey Acidic Protein) 'four-disulfide core'.","GO:0008150|biological_process;GO:0010951|negative regulation of endopeptidase activity;GO:0019731|antibacterial humoral response;GO:0043086|negative regulation of catalytic activity;GO:0045087|innate immune response;GO:0052547|regulation of peptidase activity;","GO:0005575|cellular_component;GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0003674|molecular_function;GO:0004867|serine-type endopeptidase inhibitor activity;GO:0030414|peptidase inhibitor activity;",".","."]
["ENSRNOG00000046069",5,0.420676343,1,0.064330438,6.5393048,2.70913727,0.046097741,0.024473002,"up","yes","Higd1c","protein_coding","chr7:131478519-131498214:+","gi|564361937|ref|XP_006242434.1|",506,{"v":4e-64,"d":"4.00E-64"},"PREDICTED: HIG1 domain family member 1C isoform X3 [Rattus norvegicus]","gi|672060628|ref|XM_006242372.2|",291,{"v":1e-149,"d":"1.00E-149"},"PREDICTED: Rattus norvegicus HIG1 domain family member 1C-like (LOC102555170), transcript variant X3, mRNA","Q76I25",190,{"v":3e-62,"d":"3.00E-62"},"HIG1 domain family member 1C",".",".",".",".","pfam04588","HIG_1_N","Hypoxia induced protein conserved region. This family is found in proteins thought to be involved in the response to hypoxia. Family members mostly come from diverse eukaryotic organisms however eubacterial members have been identified. This region is found at the N-terminus of the member proteins which are predicted to be transmembrane.","GO:0097250|mitochondrial respiratory chain supercomplex assembly;","GO:0005739|mitochondrion;GO:0016021|integral component of membrane;",".",".","."]
["ENSRNOG00000046343",5,0.420676343,1,0.064330438,6.5393048,2.70913727,0.046097741,0.024473002,"up","yes","Cryga","protein_coding","chr9:66482176-66509896:-","gi|564368711|ref|XP_006245126.1|",1886,0,"PREDICTED: gamma-crystallin A isoform X2 [Rattus norvegicus]","gi|672065266|ref|XM_006245064.2|",1210,0,"PREDICTED: Rattus norvegicus crystallin, gamma A (Cryga), transcript variant X2, mRNA","P10065",362,{"v":3e-121,"d":"3.00E-121"},"Gamma-crystallin A",".",".",".",".","pfam00030","Crystall","Beta/Gamma crystallin. The alignment comprises two Greek key motifs since the similarity between them is very low.","GO:0001654|eye development;GO:0002088|lens development in camera-type eye;GO:0007601|visual perception;","GO:0005575|cellular_component;","GO:0003674|molecular_function;GO:0005212|structural constituent of eye lens;","K23483","CRYG; gamma-crystallin"]
["ENSRNOG00000048686",5,0.420676343,1,0.064330438,6.5393048,2.70913727,0.046097741,0.024473002,"up","yes","AABR07066379.1","protein_coding","chr9:10664752-10683939:+","gi|564324403|ref|XP_006227191.1|",710,{"v":2E-85,"d":"2.00E-85"},"PREDICTED: disks large homolog 5-like [Rattus norvegicus]","gi|672033308|ref|XM_006227057.2|",1102,0,"PREDICTED: Rattus norvegicus similar to RIKEN cDNA 1700001E04 (LOC301748), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam04822","Takusan","Takusan. This domain is named takusan, which is a Japanese word meaning 'many'. Members of this family regulate synaptic activity.",".",".",".",".","."]
["ENSRNOG00000050672",5,0.420676343,1,0.064330438,6.5393048,2.70913727,0.046097741,0.024473002,"up","yes","Ervfrd-1","protein_coding","chr12:22151211-22158264:+","gi|62821770|ref|NP_001014771.1|",3134,0,"envelope glycoprotein syncytin-A precursor [Rattus norvegicus]","gi|333033801|ref|NM_001014771.2|",3102,0,"Rattus norvegicus syncytin a (Syna), mRNA","Q5G5D5",1089,0,"Syncytin-A",".",".",".",".","pfam00429","TLV_coat","ENV polyprotein (coat polyprotein).","GO:0000768|syncytium formation by plasma membrane fusion;GO:0006949|syncytium formation;GO:0007520|myoblast fusion;GO:0060711|labyrinthine layer development;","GO:0016021|integral component of membrane;",".","K24396","ERVFRD-1; syncytin-2"]
["ENSRNOG00000054142",5,0.420676343,1,0.064330438,6.5393048,2.70913727,0.046097741,0.024473002,"up","yes","Slc30a2","protein_coding","chr5:146559733-146571956:+","gi|133908626|ref|NP_001076591.1|",1842,0,"zinc transporter 2 isoform 1 [Rattus norvegicus]","gi|133908625|ref|NM_001083122.1|",3088,0,"Rattus norvegicus solute carrier family 30 (zinc transporter), member 2 (Slc30a2), transcript variant 1, mRNA","Q2HJ10",682,0,"Zinc transporter 2","lin2720",154,{"v":6e-40,"d":"6.00E-40"},"COG1230","pfam01545","Cation_efflux","Cation efflux family. Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells.","GO:0006829|zinc ion transport;GO:0010043|response to zinc ion;GO:0061088|regulation of sequestering of zinc ion;GO:0061090|positive regulation of sequestering of zinc ion;GO:0071577|zinc ion transmembrane transport;GO:0098655|cation transmembrane transport;","GO:0005737|cytoplasm;GO:0005770|late endosome;GO:0005886|plasma membrane;GO:0010008|endosome membrane;GO:0016021|integral component of membrane;GO:0031410|cytoplasmic vesicle;GO:0043231|intracellular membrane-bounded organelle;","GO:0005385|zinc ion transmembrane transporter activity;GO:0008324|cation transmembrane transporter activity;GO:0042802|identical protein binding;","K14689","SLC30A2, ZNT2; solute carrier family 30 (zinc transporter), member 2"]
["ENSRNOG00000056141",5,0.420676343,1,0.064330438,6.5393048,2.70913727,0.046097741,0.024473002,"up","yes","Matn3","protein_coding","chr6:31748474-31768101:+","gi|157819693|ref|NP_001101483.1|",2301,0,"matrilin-3 precursor [Rattus norvegicus]","gi|157819692|ref|NM_001108013.1|",1999,0,"Rattus norvegicus matrilin 3 (Matn3), mRNA","O35701",853,0,"Matrilin-3",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0008150|biological_process;GO:0051216|cartilage development;","GO:0005575|cellular_component;GO:0031012|extracellular matrix;GO:0062023|collagen-containing extracellular matrix;","GO:0003674|molecular_function;GO:0005509|calcium ion binding;","K19467","MATN; matrilin"]
["ENSRNOG00000062783",5,0.420676343,1,0.064330438,6.5393048,2.70913727,0.046097741,0.024473002,"up","yes","Slitrk4","protein_coding","chrX:142706338-142718575:-","gi|148710252|gb|EDL42198.1|",4109,0,"SLIT and NTRK-like family, member 4, isoform CRA_b [Mus musculus]","gi|354783262|gb|JN947763.1|",6326,0,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Slitrk4:tm1e(KOMP)Wtsi; transgenic","Q810B8",1546,0,"SLIT and NTRK-like protein 4","alr0124_1",64.3,{"v":3E-9,"d":"3.00E-09"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.",".",".",".",".","."]
["ENSRNOG00000063438",5,0.420676343,1,0.064330438,6.5393048,2.70913727,0.046097741,0.024473002,"up","yes","ENSRNOG00000063438","lncRNA","chr10:45823662-45824830:-",".",".",".",".","gi|672024839|ref|XM_008774973.1|",1169,0,"PREDICTED: Rattus norvegicus tumor necrosis factor receptor superfamily, member 13B (Tnfrsf13b), mRNA",".",".",".",".",".",".",".",".","pfam09570","RE_SinI","SinI restriction endonuclease. This family includes the SinI (recognizes and cleaves G^GWCC) restriction endonuclease.",".",".",".",".","."]
["ENSRNOG00000064067",5,0.420676343,1,0.064330438,6.5393048,2.70913727,0.046097741,0.024473002,"up","yes","ENSRNOG00000064067","lncRNA","chr7:130202745-130216614:-","gi|149032097|gb|EDL87009.1|",271,{"v":3e-27,"d":"3.00E-27"},"rCG50603 [Rattus norvegicus]","gi|186973222|gb|AC110690.6|",567,0,"Rattus norvegicus BAC CH230-290M8 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam10212","TTKRSYEDQ","Predicted coiled-coil domain-containing protein. This is the C-terminal 500 amino acids of a family of proteins with a predicted coiled-coil domain conserved from nematodes to humans. It carries a characteristic TTKRSYEDQ sequence-motif. The function is not known.",".",".",".",".","."]
["ENSRNOG00000065642",5,0.420676343,1,0.064330438,6.5393048,2.70913727,0.046097741,0.024473002,"up","yes","ENSRNOG00000065642","lncRNA","chr1:137792043-137853561:+",".",".",".",".","gi|68051863|gb|AC154141.7|",419,0,"Mus musculus chromosome 7, clone RP24-343G19, complete sequence",".",".",".",".",".",".",".",".","pfam10131","PTPS_related","6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein. This domain is found in various bacterial hypothetical membrane proteins, as well as in tetratricopeptide TPR_2 repeat protein. The exact function of the domain has not, as yet, been established.",".",".",".",".","."]
["ENSRNOG00000070177",5,0.420676343,1,0.064330438,6.5393048,2.70913727,0.046097741,0.024473002,"up","yes","ENSRNOG00000070177","lncRNA","chr10:19294305-19369019:+",".",".",".",".","gi|354793367|gb|JN957868.1|",79,{"v":3e-31,"d":"3.00E-31"},"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Ccdc99:tm1e(KOMP)Wtsi; transgenic",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["ENSRNOG00000066614",20,1.682705373,13,0.836295696,2.012093785,1.008697551,0.046132339,0.024488981,"up","yes","RGD1561143","protein_coding","chr12:17723741-17828007:-","gi|672033438|ref|XP_008756447.1|",979,{"v":7e-119,"d":"7.00E-119"},"PREDICTED: LOW QUALITY PROTEIN: paired immunoglobulin-like type 2 receptor beta isoform X1 [Rattus norvegicus]","gi|672033573|ref|XR_589536.1|",2250,0,"PREDICTED: Rattus norvegicus similar to Zinc finger, CW type with PWWP domain 1 (RGD1566138), transcript variant X1, misc_RNA","Q6IR42",271,{"v":3e-76,"d":"3.00E-76"},"Zinc finger CW-type PWWP domain protein 1",".",".",".",".","pfam07496","zf-CW","CW-type Zinc Finger. This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a \"highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development.\" Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteristic of vertebrates, higher plants and other animals in which these domain is found.",".",".",".",".","."]
["ENSRNOG00000005430",12,1.009623224,6,0.385982629,2.61572192,1.387209175,0.046650507,0.024725477,"up","yes","AABR07040944.1","protein_coding","chrX:107697440-107698439:-","gi|971450487|ref|XP_015129918.1|",351,{"v":6e-40,"d":"6.00E-40"},"PREDICTED: 40S ribosomal protein S19 [Gallus gallus]","gi|672021950|ref|XM_008776477.1|",186,{"v":4e-91,"d":"4.00E-91"},"PREDICTED: Rattus norvegicus ribosomal protein S19-like 1 (Rps19l1), mRNA","Q5R8M9",139,{"v":4E-41,"d":"4.00E-41"},"40S ribosomal protein S19","SPBC649.02",97.1,{"v":2e-25,"d":"2.00E-25"},"COG2238","pfam01090","Ribosomal_S19e","Ribosomal protein S19e.",".",".",".",".","."]
["ENSRNOG00000005920",12,1.009623224,6,0.385982629,2.61572192,1.387209175,0.046650507,0.024725477,"up","yes","AABR07054266.1","protein_coding","chr3:138600187-138600965:-","gi|157819033|ref|NP_001099680.1|",1035,{"v":2E-140,"d":"2.00E-140"},"ribonuclease T2 precursor [Rattus norvegicus]","gi|197246456|gb|BC168957.1|",507,0,"Rattus norvegicus ribonuclease T2, mRNA (cDNA clone MGC:189268 IMAGE:9098746), complete cds","C0HKG6",387,{"v":1E-135,"d":"1.00E-135"},"Ribonuclease T2-B",".",".",".",".","pfam00445","Ribonuclease_T2","Ribonuclease T2 family.",".",".",".",".","."]
["ENSRNOG00000020685",12,1.009623224,6,0.385982629,2.61572192,1.387209175,0.046650507,0.024725477,"up","yes","Atp12a","protein_coding","chr15:30443571-30468229:+","gi|675294847|ref|NP_598201.2|",5305,0,"potassium-transporting ATPase alpha chain 2 a [Rattus norvegicus]","gi|675294846|ref|NM_133517.2|",4019,0,"Rattus norvegicus ATPase H+/K+ transporting non-gastric alpha2 subunit (Atp12a), transcript variant 1, mRNA","P54708",2045,0,"Potassium-transporting ATPase alpha chain 2","MA4378",612,0,"COG0474","pfam00122","E1-E2_ATPase","E1-E2 ATPase.","GO:0006883|cellular sodium ion homeostasis;GO:0006885|regulation of pH;GO:0010038|response to metal ion;GO:0010248|establishment or maintenance of transmembrane electrochemical gradient;GO:0014070|response to organic cyclic compound;GO:0030007|cellular potassium ion homeostasis;GO:0036376|sodium ion export across plasma membrane;GO:0055075|potassium ion homeostasis;GO:0071805|potassium ion transmembrane transport;GO:1902600|proton transmembrane transport;GO:1990573|potassium ion import across plasma membrane;","GO:0005886|plasma membrane;GO:0016021|integral component of membrane;GO:0016323|basolateral plasma membrane;GO:0016324|apical plasma membrane;","GO:0005391|sodium:potassium-exchanging ATPase activity;GO:0005515|protein binding;GO:0005524|ATP binding;GO:0008900|potassium:proton exchanging ATPase activity;GO:0046872|metal ion binding;","K01544","ATP12A; non-gastric H+/K+-exchanging ATPase [EC:7.2.2.19]"]
["ENSRNOG00000067275",12,1.009623224,6,0.385982629,2.61572192,1.387209175,0.046650507,0.024725477,"up","yes","ENSRNOG00000067275","lncRNA","chr17:75172754-75180279:+","gi|33086586|gb|AAP92605.1|",265,{"v":9e-22,"d":"9.00E-22"},"Ab2-389 [Rattus norvegicus]","gi|256985238|gb|AC118412.6|",822,0,"Rattus norvegicus CH230-221E17 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence",".",".",".",".",".",".",".",".","pfam11301","DUF3103","Protein of unknown function (DUF3103). This family of proteins with unknown function appear to be restricted to Proteobacteria.",".",".",".",".","."]
["ENSRNOG00000068034",12,1.009623224,6,0.385982629,2.61572192,1.387209175,0.046650507,0.024725477,"up","yes","ENSRNOG00000068034","protein_coding","chr17:42760219-42793359:-","gi|157822485|ref|NP_001101884.1|",558,{"v":7e-69,"d":"7.00E-69"},"histone cluster 1, H2bd [Rattus norvegicus]","gi|157822484|ref|NM_001108414.1|",377,0,"Rattus norvegicus histone cluster 1, H2bd (Hist1h2bd), mRNA","P10854",218,{"v":9e-70,"d":"9.00E-70"},"Histone H2B type 1-M",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.",".",".",".",".","."]
["ENSRNOG00000069618",12,1.009623224,6,0.385982629,2.61572192,1.387209175,0.046650507,0.024725477,"up","yes","RGD1565057","protein_coding","chr1:226689398-226705316:-","gi|589942527|ref|XP_006983976.1|",1310,{"v":1E-166,"d":"1.00E-166"},"PREDICTED: tektin-5 [Peromyscus maniculatus bairdii]","gi|45825220|gb|AC113961.14|",885,0,"Mus musculus chromosome 19, clone RP23-18G1, complete sequence","G5E8A8",504,{"v":4e-166,"d":"4.00E-166"},"Tektin-5",".",".",".",".","pfam03148","Tektin","Tektin family. Tektins are cytoskeletal proteins. They have been demonstrated in such cellular sites as centrioles, basal bodies, and along ciliary and flagellar doublet microtubules. Tektins form unique protofilaments, organized as longitudinal polymers of tektin heterodimers with axial periodicity matching tubulin. Tektin polypeptides consist of several alpha-helical regions that are predicted to form coiled coils. Indeed, tektins share considerable structural similarities with intermediate filament proteins. Possible functional roles for tektins are: stabilisation of tubulin protofilaments; attachment of A and B-tubules in ciliary/flagellar microtubule doublets and C-tubules in centrioles; binding of axonemal components.",".",".",".",".","."]
["ENSRNOG00000020614",8,0.673082149,3,0.192991315,3.487629227,1.802246674,0.049537681,0.026103266,"up","yes","Phlda2","protein_coding","chr1:198696897-198697836:-","gi|672039228|ref|XP_008758317.1|",766,{"v":8e-100,"d":"8.00E-100"},"PREDICTED: pleckstrin homology-like domain family A member 2 isoform X1 [Rattus norvegicus]","gi|282165683|ref|NM_001100521.1|",705,0,"Rattus norvegicus pleckstrin homology-like domain, family A, member 2 (Phlda2), transcript variant 1, mRNA","O08969",248,{"v":5e-82,"d":"5.00E-82"},"Pleckstrin homology-like domain family A member 2",".",".",".",".","pfam00169","PH","PH domain. PH stands for pleckstrin homology.","GO:0001890|placenta development;GO:0009887|animal organ morphogenesis;GO:0010468|regulation of gene expression;GO:0030334|regulation of cell migration;GO:0043065|positive regulation of apoptotic process;GO:0045995|regulation of embryonic development;GO:0060721|regulation of spongiotrophoblast cell proliferation;GO:0070873|regulation of glycogen metabolic process;GO:1903547|regulation of growth hormone activity;","GO:0005737|cytoplasm;","GO:1901981|phosphatidylinositol phosphate binding;","K23793","PHLDA; pleckstrin homology-like domain family A"]
["ENSRNOG00000053476",8,0.673082149,3,0.192991315,3.487629227,1.802246674,0.049537681,0.026103266,"up","yes","AABR07062350.1","lncRNA","chr4:169351795-169385811:-",".",".",".",".","gi|672018869|ref|XR_346206.2|",340,{"v":6E-176,"d":"6.00E-176"},"PREDICTED: Rattus norvegicus uncharacterized LOC102549638 (LOC102549638), transcript variant X3, ncRNA",".",".",".",".",".",".",".",".","pfam08324","PUL","PUL domain. The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated domain. It directly binds to Cdc48, a chaperone-like AAA ATPase that collects ubiquitylated substrates.",".",".",".",".","."]
["ENSRNOG00000066493",8,0.673082149,3,0.192991315,3.487629227,1.802246674,0.049537681,0.026103266,"up","yes","ENSRNOG00000066493","protein_coding","chr19:39079782-39080340:+","gi|149065782|gb|EDM15655.1|",280,{"v":1e-29,"d":"1.00E-29"},"similar to hypothetical protein supported by AL449243 (predicted), isoform CRA_b [Rattus norvegicus]","gi|255004822|gb|AC111287.5|",290,{"v":5e-149,"d":"5.00E-149"},"Rattus norvegicus CH230-55H2 (Children's Hospital Oakland Research Institute Rat (BN/SsNHsd/MCW) BAC library) complete sequence","Q9DB10",111,{"v":5e-31,"d":"5.00E-31"},"Essential MCU regulator, mitochondrial",".",".",".",".","pfam10161","DDDD","Putative mitochondrial precursor protein. This is a family of small conserved proteins found from nematodes to humans. The C-terminal region is rich in asparagine. Members are putatively assigned to be mitochondrial precursor proteins but this could not be confirmed.",".",".",".",".","."]
["ENSRNOG00000068092",8,0.673082149,3,0.192991315,3.487629227,1.802246674,0.049537681,0.026103266,"up","yes","ENSRNOG00000068092","lncRNA","chr11:26881938-26937359:+","gi|68000776|ref|XP_669718.1|",158,{"v":1E-10,"d":"1.00E-10"},"hypothetical protein [Plasmodium berghei strain ANKA] [Plasmodium berghei ANKA]","gi|672070685|ref|XR_358121.2|",398,0,"PREDICTED: Rattus norvegicus uncharacterized LOC102554346 (LOC102554346), ncRNA",".",".",".",".",".",".",".",".","pfam15351","JCAD","Junctional protein associated with coronary artery disease. JCAD is a component of VE-cadherin-based cell-cell junctions in endothelial cells. The cell-cell or adherens junction is an adhesion complex that plays a crucial role in the organisation and function of epithelial and endothelial cellular sheets. These junctions join the actin cytoskeleton to the plasma membrane to form adhesive contacts between cells or between cells and extracellular matrix. The junctions also mediate both cell adhesion and cell-signalling. JCAD localizes close to the apical membrane in epithelial cells. This family is found in eukaryotes.",".",".",".",".","."]